bluuebunny/crossref_metadata_2025 huggingface dataset:
Anxiety, Depression and Some Related Factors in Infertile Couples Being Treated at a Provincial Reproductive Health Care Center, in the South of Vietnam
Authors: Anh Vo Thi Kim , Huy Tran Quang , Huong Tran Van , Quyen Lac Tran Nguyet , Dung Truong Viet
Published: April 2023

Objective: Infertile couples experienced a tremendous amount of emotional turmoil as the result of their diagnosis and have struggled to conceive, leading to an increased risk of anxiety and depression. In Vietnam, few authors mention anxiety and depression in couples undergoing infertility treatment, especially in rural areas where the qualification and technology in infertility treatment is limited than specialized hospitals in big cities. This study was conducted to determine the prevalence of anxiety and depression in couples undergoing infertility treatment and some related factors.
Materials and methods: The descriptive cross-sectional study was carried out from November 2020 to May 2021. The study subjects included 385 couples (385 wives and 385 husbands) who came for infertility examination and treatment at the Department of Reproductive Health Care, Center for Disease Control (CDC) of KienGiang Province. The Vietnamese version of the DASS 21 scale was used to measure anxiety and depression through face-to-face interviews with a structured set of questions. Participants were also asked about demographics, socioeconomic status, infertility-related characteristics, and family relationships.
Results and Discussion: The prevalence of anxiety among wives is higher than that of husbands (46.2% and 33.3%), similarly the prevalence of depression among wives (17.7%) is also higher than that of husbands (10.06%). Most couples have mild or moderate anxiety disorders, the same goes for depression. In husbands, there is a factor related to anxiety that is living separately (i.e. the couple does not live with their parents in the same house) and there are 2 factors related to depression which are living separately and family economic conditions. Among the wives, more factors were found to be associated with anxiety and depression, including age, living separately, family economic conditions and duration of infertility.
Conclusion: The prevalence of anxiety and depression among infertile couples in the rural province of the South, Vietnam is high. Although most anxiety and depression levels are mild or moderate, emotional and mental support must be integrated with clinical support is really necessary, helping to improve the patient’s quality of life and indirectly improve the effectiveness of infertility treatment.
Bangladesh Journal of Medical Science Vol. 22 No. 02 April’23 Page : 360-367
Serum ferritin status and mitochondrial function in children
Authors: KhAljammas Elham , Kataan Muhammed A Ahmed Al , Hafidh Nashwan M Al
Published: April 2023

objective: Iron is the most abundant metal within the mitochondrial matrix . Ferritin reflects bodyironstores. This study aimed to assess the association between serum ferritin levels and mitochondrial function in children.
Methods: Two hundred and forty-three children from four governmental primary schools in Mosul city in Iraq were randomly selected by a multistage random sampling method. Their age range was 6-12 years. Mitochondrial function tests involved measurement of serum lactate, serum pyruvate, and L-Carnitine were analyzed in all selected children along with serum ferritin.
Results: Lower levels of serum ferritin weresignificantly associated with higher levels of serum lactate, serum lactate/serum pyruvate ratio. There was a significant negative correlation (p = 0.000, - 0.296,- 0.286) between mean serum ferritin level and mean serum lactate, serum lactate / serum pyruvate ratio respectively.There were significant differences (p= 0.000) in mean serum level of mitochondrial function tests (Lactate, L- Carnation, and L/P ratio) in comparing children possessing a normal level of serum ferritin versus those with a low serum ferritin level of < 12 ng/ml. ROC analysis showed that when the area under the curve (AUC) was 0.761 ± SE 0.37, a cut off value 4.79 ng/ml of serum ferritin was significantly (p=0 .000) associated with sensitivity of 100 % and 1- specificity of 0.861 value with presence of L: P molar ratio of ≤ equal 20.
Conclusion:Serum ferritin < 12 ng/ ml represntsmitochondrial deficient level. Serum ferritin < 4.79 ng/ml was the critical value at which only 8.6% of children will have a healthy mitochondrial function.
Bangladesh Journal of Medical Science Vol. 22 No. 02 April’23 Page : 374-378
Mild Androgen Insensitivity Syndrome presenting in male with infertility and sexual difficulties
Authors: Mukhtar Ahmad Faiq , Ismail Shaiful Bahari , AK Azidah , MN Norhayati , N Mohd Yunus
Published: April 2023

Androgen insensitivity syndrome has a wide spectrum of presentations. It results from a mutation in androgen receptor (AR) gene. It ranges from mild androgen insensitivity syndrome (MAIS) which is the mildest form to complete androgen insensitivity syndrome (CAIS). In case of MAIS, the abnormality that can be observed appears to be male infertility and sexual difficulties including premature ejaculation and erectile dysfunction. In this case report, we discuss a case of MAIS in a 37-year-old male who presented with infertility, premature ejaculation, and secondary erectile dysfunction.
Bangladesh Journal of Medical Science Vol. 22 No. 02 April’23 Page : 442-444
Assessment of Hand Hygiene Knowledge and Practices among Private Dental Clinics in Munshiganj, Bangladesh: A Cross-Sectional Study
Authors: Haque Samiul , Mahbub Shirmeen , Anisuzzaman Mostafa Md , Chakraborty Subodh Chandra , Gupta Sudeshna Priyadarshini Das
Published: April 2023

Introduction: The study was performed to assess knowledge about infection control through hand-washing practices among dentists and paramedical professionals working at private dental clinics and provide help to identify and overcome obstruction towards proper hand hygiene pattern.
Method: A questionnaire-based study was supervised at 15 different private dental clinics situated in the Munshiganj district of Bangladesh. Data on handwashing practices and other factors were collected from 60 samples during the months of November and December 2020. Site inspections of and washing facilities were also supervised. The data was analyzed on SPSS.
Result: Majority (78.3%, 50.0% & 35.0%) of the respondents strongly agreed that hand washing helps to prevent spread of infection to the patients. Less than half (48.3%) of the respondents washed their hands before wearing gloves. 31 doctors claimed that hand washing is done after termination of duty while 10 claims that they wash hands after each examination (p< 0.001). And most of the doctors use antibacterial soap (p=0.004).
Conclusion: The study wraps up that most of the health care providers had the education about the advantage of handwashing, but proper technique was not followed. The reasons given for not adopting handwashing practices were shortage of time, being busy with a greater number of patients, a skin reaction, and an unsuitable atmosphere.
Update Dent. Coll. j: 2023; 13(1): 23-26
Artificial Intelligence (AI) Driven Digital Dentistry
Authors: Noor Osama Bin
Published: April 2023

The COVID-19 pandemic has brought significant changes to the way healthcare is delivered, including in the field of dentistry. Teledentistry, the practice of providing dental care remotely using digital technology, has become increasingly popular, and the use of Artificial Intelligence (AI) in teledentistry has emerged as an important tool for dental care, education, and research. AI algorithms are being utilized to assist in the diagnosis, treatment planning, and prediction of treatment outcomes in various dental branches, including operative dentistry, periodontics, prosthodontics, and orthodontics. With the ability to simulate treatment outcomes and identify abnormal spots in radiographs, AI is transforming dentistry from a curative to a personalized predictive and preventive paradigm.
Update Dent. Coll. j: 2023; 13(1): 1-2
Temperature dependent development and population performance of Tetranychus fijiensis Hirst (Acari: Tetranychidae) on Papaya
Authors: Veerlapati Shivakumar , Srinivasa N.
Published: April 2023

Developmental biology and life table characteristics of Tetranychus fijiensis Hirst (Acari: Tetranychidae) on papaya were studied at four distinct constant temperatures (20, 24, 28, and 32°C) and relative humidity (70-85%) conditions. With the increase in rearing temperature conditions, the length of T. fijiensis life cycle decreased from 34.46 to 8.58 days. At 20, 24, 28, and 32°C, the Net Reproduction Rate (R0) was 23.48, 39.06, 33.75, and 23.48 and; the intrinsic rate of population increase (rm) was 0.0694, 0.2003, 0.2281, and 0.1902 females/ female/day, respectively. The optimum temperature for mite development was observed to be between 24 and 28°C, while favourable temperature for optimal reproduction capacity of the mite was 28°C.
Studies on external genitalic attributes of two species of genus Traminda Saalmüller (Lepidoptera, Geometridae, Sterrhinae) from India
Authors: Goyal Tarun , Kirti Jagbir Singh , Stella S. Staklin
Published: April 2023

Two species i.e., mundissima (Walker) and aventiaria (Guenee) belonging to genus Traminda Saalmüller of subfamily Sterrhinae have been collected from different localities of India. The external male and female genitalial structures are studied in detail and a key to the species is given. The diagnosis of genus Traminda Saalmüller along with first reference, type species and distribution is also mentioned in the present manuscript.
Coptosoma variegatum (Herrich-Schäeffer, 1838) (Hemiptera, Plataspidae) infesting mango in Kerala and Karnataka with redescription of the species
Authors: Jacob Jyothi Sara , Salini S. , Shanas S.
Published: April 2023

The incidence of Coptosoma variegatum (Herrich-Schäeffer, 1838) on mango tree is reported for the first time from south Indian states, Kerala and Karnataka. The bugs colonised and fed on tender shoots of mango trees. Even though the extent of damage was low, the insect in association with other pests may affect the vigour of young trees. The species is redescribed and illustrated based on male and female genitalia.
Record of Onomarchus uninotatus (Serville, 1838) (Orthoptera, Tettigoniidae) as a pest of jackfruit from Kerala, India
Authors: Sreeja P. , Lenin Neena , Bhaskar Haseena , Chellappan Mani , Bhaskar Dhaneesh
Published: April 2023

Onomarchus uninotatus (Orthoptera, Tettigoniidae), one of the neotropical Pseudophyllinae is recorded on the jackfruit (Artocarpus heterophyllus) var. Vietnam Super Early at Thrissur, Kerala, India. This is a new distributional report of the species from Kerala and additional new documentation as a serious pest of jackfruit from India. The nymphs and adults are nocturnal in habit and feed on the leaves resulting in withering and drying of the leaves giving a burned up appearance to the canopy. The species exhibited colour polyphenism with green and brown morphs in the nymphal stages. A detailed description of the nature of damage caused by the pest is given.
Method of Bioenergy Diagnostics of the Physical Field of the Human Body (Qigong Hand Diagnostics)
Authors: Zdravkov George
Published: April 2023

The article represents the ability of the human skin sensitive receptors and receptors of the proprioception to detect and code the physical field around the human body. The Method of Bioenergy Diagnostics is based on the trained ability of the medical practitioner`s skin to feel the physical field of the patient’s body. The Method of Bioenergy Diagnostics includes the full classification of the skin sensations to the physical field of the patient’s body (34 sensations); electro- neurophysiological patterns as the evidence for the skin sensations; the sensitive images of the etiological factors, acupuncture points and syndromes in the Traditional Chinese Medicine; sensitive images of the fifty diseases in the Western medicine; electro-neurophysiological patterns as the evidence for the sensitive images of the syndromes in the Traditional Chinese medicine and the diseases in the Western medicine. To build the Method of Bioenergy Diagnostics, it was used on 5,500 patients, 23 persons with extended skin sensitivity. The verification of the skin sensations to the components of the physical field of the human body and the sensitive images of the diseases in the Western medicine and syndromes in the Traditional Chinese Medicine were made by the BIOPAC System 150.
Higher Interleukin Receptor Levels in Mothers of Autistic Children
Authors: A.J Russo , Mensah Albert , Bowman Judith , Garcia Barbara , Padgett Katherine , Lukasik James
Published: April 2023

Interleukin (IL) receptor expression has been shown to increase significantly during maternal immune activation. It has been suggested that dysfunctional Interleukin activity is associated with cortical dysplasia and ASD-like behaviors. We measured the concentration of 30 cell receptors, including 5 Interleukin receptors (IL-1R, IL-2R, IL-10R, IL-17R and IL-21R) from mothers with at least one autistic child and neurotypical, gender and age similar controls, using immune-arrays. Of the 5 Interleukin receptors, 4 (IL-1R, IL-10R, IL-17R and IL-21R) had concentrations significantly higher in mothers of autistic children, when compared to neurotypical controls.
KÜÇÜK KONUTLARDA İÇ MEKÂN SABİT DONATILARIN DEPOLAMA KAPASİTELERİNDEKİ MEMNUNİYETİNİN ARAŞTIRILMASI
Authors: ÇINAR Hatice , ÇINAR Kerim
Published: April 2023

Günümüzde küreselleşmeyle beraber yaşanan toplumsal, kültürel ve aile hayatında yaşanan değişimler sonucu insanların talep ve ihtiyaçları da değişmiştir. Yaşam tarzındaki değişiklikler, ailedeki küçülme, bireyselleşme ve tek kişilik yaşama biçimi gibi nedenlerden dolayı konutlarda mekânsal olarak küçülmeye gidilmiş ve günümüzde 1+0, 1+1, 2+1 olarak üretilen küçük konut tipolojilerinden en fazla yaygın kullanım gösteren ‘stüdyo tipi’ konutların üretimi artmıştır. Bu araştırmada aynı mimari özelliklere sahip stüdyo dairelerde toplu olarak tasarlanmış iç mekân sabit donatı elemanlarının (vestiyer, mutfak dolabı, banyo dolabı ve elbise dolabı) depolama kapasiteleri ile ilgili kullanıcı memnuniyetleri veya varsa şikâyetlerinin tespit edilmesi amaçlanmıştır. Çalışmada varsayılan, küçük konut iç mekân sabit donatıların depolama kapasitesi konut tipi büyüklüklerine göre farklılıklar göstereceği yönündedir. Bu amaçla, Konya’nın Selçuklu ilçesindeki stüdyo tipi konutta 259 küçük konut kullanıcısına bir anket uygulanmıştır. Araştırma sonucunda, 2+1 ve 2+1 dubleks dairede oturan kullanıcıların diğer kullanıcılara oranla konut iç mekan sabit donatılarının depolama kapasitesinden memnuniyetlerinin yüksek olduğu ortaya konmuş ve konuttaki birey sayısının değişiminin depolama kapasitesi memnuniyetine etkisinin olmadığı görülmüştür. Ayrıca kullanıcıların sabit donatı elemanlarının estetik ve ergonomik olarak değerlendirmeleri de dikkat çekici bir özellik olarak tespit edilmiştir.
FİZİKSEL ENGELLİ KULLANICILARIN OFİS İÇ MEKÂN DONATI ELEMANLARINA YÖNELİK ERGONOMİK BİR ARAŞTIRMA
Authors: YILDIRIM Kemal , MÜEZZİNOĞLU Menşure Kübra , GÜN Kübra
Published: April 2023

Bu çalışmada; tekerlekli sandalye kullanan fiziksel engelli bireylerin ofis mekânları ve donatı elemanlarıyla ilgili yaşadığı sorunların belirlenmesi amaçlanmıştır. Bu amaçla, tekerlekli sandalye kullanan bireylerin ofis mekânlarında yaşadıkları sorunlar ile istek ve gereksinimlerini belirlemek için tesadüfi olarak seçilen 40 katılımcıya araştırma anketi uygulanmıştır. Araştırmanın sonucunda, tekerlekli sandalye kullanan bireylerin önemli bir bölümünün ofislerinde bulunan çalışma, yönetici ve toplantı masalarına, kitaplıklara, dosya dolaplarına, askılıklara, mutfak ve banyo dolaplarına, orta masası/sehpalara, soğutucuya, fırına, bulaşık makinesine, kapının koluna, priz ve elektrik anahtarına erişemedikleri, yine engelli bireylerin klozete, lavaboya ve oturma mobilyasına rahat geçiş sağlayamadığı, bazı odalar arasındaki kot ve kapı eşiği yüksekliği nedeniyle geçiş sorunları yaşadığı, ayrıca döşeme yüzeyinin özelliklerinden kaynaklı olarak rahat ve kolay hareket edemedikleri belirlenmiştir. Sonuçta, elde edilen bu sonuçlara göre, mevcut kanun ve standartlar da dikkate alınarak öneriler sunulmuştur.
Assistência de enfermagem: os desafios enfrentados no processo da sedação
Authors: Santana Alicia Victória Bomfim de , Santana Keylla Najeane Matos , Souza Monallyse Santos de , Santos Sandro Oliveira Figueredo dos
Published: April 2023

Objetivo: O presente estudo teve o objetivo de avaliar os desafios e limitações que a assistência de enfermagem enfrenta durante o processo de sedação. Metodologia: Trata-se de uma pesquisa de revisão de literatura integrativa de caráter descritivo, com abordagem qualitativa. Para realização deste estudo foram utilizadas as bases de dados: Portal Regional da Biblioteca Virtual em Saúde (BVS), Scientific Electronic Library Online (SciELO) e a Biblioteca Nacional de Medicina (PubMed). Utilizaram-se os critérios de inclusão: artigos publicados entre os anos de 2012 a 2022, que abordassem o tema de forma clara e objetiva, disponíveis em língua portuguesa, inglês ou espanhol. Já os critérios de não inclusão: foram: artigos incompletos, repetidos nas bases de dados, que fugissem da temática proposta ou não estivessem no período indicado e no idioma proposto.  Resultados e Discussão: A principal limitação da assistência de enfermagem na UTI é a falta de autonomia no processo de sedação, portanto não cabe a equipe de enfermagem intervir ou prescrever as doses ou medicações, sendo função do enfermeiro administrar as medicações, checar a dosagem e fármaco antes de aplicar e, monitorar as respostas do paciente sedado. Os dois grandes desafios que a equipe de enfermagem enfrenta é a ausência de protocolos na sedação e a falta de treinamento adequado para as equipes de enfermagem. Conclusão: A equipe de enfermagem exerce um papel fundamental no processo de sedação, pois ela atua no monitoramento e cuidado do paciente sedado até que o mesmo se recupere.
Avaliação clínica, parasitológica e socioeconômica de crianças atendidas na pediatria da comunidade Nosso Lar- vergel do lago, Maceió-Alagoas
Authors: Ferro Renata Marcela Cavalcante Ferreira , Silvestre Maria Eduarda Ramos , Almeida Ana Carolina Medeiros de , Oliveira Gilsan Aparecida de , Bezerra Emanuel Felipe Marques , Moura Lívia Lorena Santos , Silva Maria Karoline Gomes , Souza Larissa Gouveia Aragão de
Published: April 2023

As crianças em idade escolar abarcam um grupo com maior propensão a exposição em ambientes contaminados, o que favorece o acometimento de patologias causadas por geo-helmintos. Diante disso, o presente estudo tem como intuito constatar as alterações clínicas e socioeconômicas associadas à infecção por parasitoses no público infantil. Trata-se de um estudo observacional transversal para verificar as alterações clínicas, parasitológicas e socioeconômicas de crianças atendidas na pediatria da comunidade nosso lar, localizada no bairro Vergel do Lago, Maceió-AL. Foi constatado entre as amostras de material biológico que 20,4% positivaram para helmintos gastrointestinais, dos quais 66,7% positivaram para Ascaris lumbricoides, 22,2% para Ancylostoma duodenale e 11,1% para Hymenolepis diminuta, bem como, foi averiguado que 39% das crianças ingerem água proveniente da torneira, 42,8% não tem o hábito de higienizar as mãos antes das refeições e mais da metade não possui saneamento básico em suas residências. Observou-se ainda que a maioria das mães apresentavam ensino fundamental incompleto e a maioria possuía renda de até 1 salário mínimo. Com isso, conclui-se que as condições de saneamento e higiene contribuíram para o número de positivos. A prevalência do Ascaris lumbricoides propõe a baixa adesão ao hábito de higienizar mãos por parte das crianças. Grande parte delas moravam com cerca de sete pessoas e em casa alugada, com renda baixa, evidenciando o precário nível socioeconômico destas. Além disso, o baixo nível de escolaridade das mães predispõe a resistência significativa para retornar com a amostra de fezes.
Perfil dos pacientes em uso de isotretinoína em um ambulatório de uma universidade privada no Piauí: uma análise exploratória e descritiva
Authors: Santos Maria Clara Leônidas , Carvalho Rubens Leite de , Sousa Júnior Weslly Lopes , Galvão Evandra Marielly Leite Nogueira Freitas
Published: April 2023

Objetivo: Descrever o perfil dos pacientes em uso de isotretinoína no ambulatório de uma universidade privada de Teresina; traçar o perfil dos pacientes de acordo com o sexo, idade e classificação da acne; identificar fatores socioeconômicos e condições psicológicas relacionadas à adesão ao tratamento de isotretinoína; determinar comportamentos sociais adotados pelos pacientes em uso de isotretinoína; verificar a existência e a adesão a tratamentos prévios. Métodos: Trata-se de uma análise dos dados contidos nos prontuários dos pacientes do ambulatório de Dermatologia de uma Universidade privada do Piauí que procuraram atendimento no período de janeiro de 2021 até agosto de 2022 e estão em uso de isotretinoína para o tratamento da Acne, independentemente do sexo ou idade. Resultados: Participaram deste estudo 30 pacientes, regularmente acompanhados no local da pesquisa., sendo 56,6% (17) do sexo feminino e 43,3% (13), do sexo masculino. A média geral de idade dos pacientes foi de 21,9 ± 4,0 anos e a mediana de 21 anos. A idade mínima foi de 18 anos e a máxima foi de 36 anos. Quanto à faixa etária, a distribuição mostra que 47% dos pacientes têm entre 18 e 20 anos. Conclusão: Observou-se neste estudo que o perfil dos pacientes atendidos com acne nesse local é, portanto, de pacientes do sexo feminino, idade aproximada de 18 a 20 anos, com quadro de acne inflamatória moderada, que se mantinham em tratamento com Isotretinoína e anticoncepcionais.
Mengasah Kemampuan Bisnis Pemuda Desa Kadumaneuh
Authors: Nurhayati Ely , Suyana Hilma , Budiman Andika Nuraga , Tambuati Hesty Juni , Nurisma Firra
Published: April 2023

Status Desa Kadumaneuh saat ini merupakan desa berkembang, belum menjadi Desa maju ataupun mandiri. Beberapa tantangan yang dihadapi Desa Kadumaneuh adalah masih tingginya pengangguran. Selain itu, pekerja di desa tersebut sebagian besar juga merupakan pekerja kasar, yaitu buruh, kuli, serta petani. Berdasarkan latar belakang tersebut karenanya dilakukan kegiatan pengabdian masyarakat yang bertujuan mengasah kemampuan bisnis pemuda Desa Kadumaneuh. Dengan kegiatan ini, diharapkan ke depan masalah pengangguran di desa tersebut dapat terminimalisir, sehingga menjadi sejahtera, serta mencapai posisi desa mandiri atau maju. Adapun kegiatan yang relevan dilakukan di Desa tersebut, salah satunya yaitu kegiatan mengasah kemampuan bisnis pemuda Desa Kadumaneuh. Tujuan dari kegiatan PKM di Desa Kadumaneuh ini adalah (1) membantu meningkatkan kesejahteraan masyarakat desa, (2) mengasah kemampuan bisnis pemuda Desa Kadumaneuh, (3) membekali peserta dengan dasar-dasar ilmu bisnis yang dibutuhkan, (4) memberikan edukasi terkait dasar-dasar bisnis, (5) memberikan edukasi terkait manajemen keuangan, serta (6) memberikan edukasi terkait dengan akses modal. Metode pelaksanaan kegiatan ini adalah seminar dan workshop. Setelah dilakukan kegiatan PkM, secara umum pengetahuan dan kemampuan bisnis peserta mengalami peningkatan.
ARTIFICIAL INTELLIGENCE AS A TOOL OF PUBLIC MANAGEMENT OF SOCIO-ECONOMIC DEVELOPMENT: ECONOMIC SYSTEMS, SMART INFRASTRUCTURE, DIGITAL SYSTEMS OF BUSINESS ANALYTICS AND TRANSFERS
Authors: KARPA MARTA , KITSAK TARAS , DOMSHA OLHA , ZHUK OLHA , AKIMOVA LIUDMYLA , AKIMOV OLEKSANDR
Published: April 2023

The article considers the modern development of public administration in its connection with the use of digital technologies in order to increase the effectiveness of the activities of government bodies, their focus on the needs of the population, expand the possibility of implementing the social functions of the state, openness of decision-making processes and civil control of management activities. It is shown that on the basis of digitalization and, in particular, application of artificial intelligence solutions, the content of public administration, individual procedures and stages of the management cycle, as well as state functions are changing. The best practices of using artificial intelligence in digital public administration systems of various countries are considered, the possibilities of using smart solutions in systems of sustainable development of territories, in analytics and intergovernmental transfers within the framework of regional development are described.
PUBLIC-PRIVATE PARTNERSHIP AS A TOOL FOR IMPLEMENTING STATE POLICY
Authors: GAIEVSKA LARYSA , KARLOVA VALENTYNA , BOBROVSKA OLENA , KULYNYCH MYROSLAVA , AKIMOVA LIUDMYLA , AKIMOV OLEKSANDR
Published: April 2023

The article discusses the theoretical and methodological foundations for the formation and development of public-private partnerships in the modern economy, the need and economic essence of public-private partnerships, as well as models and forms of interaction in such partnerships, including examples of the implementation of this mechanism in various countries and regions. It is shown that in the modern world the institution of public-private partnership is becoming more widespread and constitutes the basis for the implementation of various infrastructure, municipal and community development, etc. projects at all levels of government. Based on the elements of case study method, public-private partnership is considered as the basis for the development of socio-economic systems in modern conditions.
Clinical Management of Fibromyalgia and the Continuum of Polysymptomatic Distress Disorders
Authors: Fleming Kevin C.
Published: April 2023

The evaluation of patients with fibromyalgia (FM) and other functional somatic syndromes can appear intimidating, but a high index of suspicion and a more systematic approach can improve provider efficiency, reduce frustration, and improve the care experience. FM is a dimensional rather than a categorical disorder, reflecting a continuous spectrum of physical symptoms; it is formally diagnosed after reaching a critical mass of widespread pain and symptom severity. Central sensitisation is a maladaptive neuroplastic response in the higher brain neural pain network that accounts for FM symptoms. Rheumatologists are a scarce medical resource, so their involvement in FM can be considered along ‘focussed factory’ or ‘solution shop’ approaches. Multimodal FM treatments should include pharmacologic and nonpharmacologic therapies including cognitive therapies, graded exercise, and stress management.
Ocular Manifestations of Whiplash Injury
Authors: Pei Ling Celeste Yong , Sanjay Srinivasan
Published: April 2023

Introduction: Whiplash or indirect injuries to the neck are a common occurrence because of motor vehicle collisions, in which the frequency of ocular complications is largely unknown.

Aim: We aim to review the ocular manifestations, the utility of relevant diagnostic tests, the management, prognosis, and sequelae of whiplash-related ocular complications.

Methods: A comprehensive literature search was conducted on Medline®, PubMed®, Google Scholar™, and Cochrane databases. Only articles published or translated into the English language from 1985–2015 were considered and key data from the full article of each paper were extracted and evaluated.

Results: The authors’ search yielded 41 articles. Blurring of vision was the most common presenting symptom. Other common presenting symptoms included words and objects moving within the visual field as well as difficulty in concentration. Ocular findings involved: disturbed eye movements; vestibulo-ocular reflex and cervico-ocular reflex dysfunction; anterior segment abnormalities such as accommodative and convergence dysfunction and relative afferent papillary defect; and posterior segment abnormalities such as macular oedema and foveal lesions. The treatment for ophthalmic complications of whiplash injuries is mainly conservative and revolves around neck physiotherapy and oculomotor rehabilitation. The prognosis of the ocular injury depends on the ocular findings as well as the interval between whiplash injury and treatment initiation.

Conclusion: Whiplash injuries occur commonly in motor vehicle accidents. While patients may present asymptomatically, a myriad of ophthalmic complications may be detected. Prognosis for ocular complications depends mainly on the severity of complication(s), the time lapse between injury and detection of complication(s), and the initiation of treatment. Ophthalmologists and physicians should be aware and vigilant towards patients following whiplash injury as a small minority of patients may have poor visual outcome and quality of life without treatment and follow-up.
Precision Medicine: Maximising Treatment Benefit for Rheumatoid Arthritis Patients
Authors: Lale Alice
Published: April 2023

This educational symposium was opened by Prof Ernest Choy, who introduced the concept of precision medicine and highlighted the importance of integrating current research with clinical experience to guide treatment decisions. He also highlighted the growing recognition of precision medicine within rheumatology. Prof Eric Ruderman then explored current medical views around the use of glucocorticoids (GCs) in rheumatoid arthritis (RA), revealing how uncertainty over the true risk/benefit ratio of these agents means that their impact as part of patient care must be further studied. Next, Prof Cem Gabay reviewed the evidence from clinical trials, registries, and real-world studies supporting biologic monotherapy as a treatment strategy in patients for whom methotrexate (MTX) is inappropriate. Prof Georg Schett then considered how current biomarker research might influence patient care in the future, especially with respect to assessing disease course and treatment responses in RA. Finally, Prof Choy presented a series of patient case studies, featuring practical issues faced by rheumatologists in the clinic, and drew upon the themes of the preceding presentations to highlight the value of a precision medicine approach to RA. Following closing remarks from Prof Choy, a lively discussion session enabled the audience to ask the expert panel about the wider clinical implications of their views.

The pivotal role of IL-6 in RA5 was explored in a video at the beginning of the session, which highlighted the importance of further research in this area (available to view here).
The Evolving Landscape of Rheumatology: Biosimilarity and Extrapolation
Authors: Smithers Lucy
Published: April 2023

Targeted biological therapies have revolutionised the treatment of inflammatory diseases in rheumatology and new agents continue to be developed. The growing demand, coupled with limited competition, is a challenge for healthcare budgets and limits patients’ access to these therapies. Biosimilars, which are biologicals with comparable safety, quality, and efficacy to a reference product, have the potential to address these challenges. Despite biosimilars having been available since 2006, initially in other indications than rheumatoid arthritis (RA), confidence in their use is still an issue for rheumatologists. This symposium discussed the rigorous scientific and regulatory processes by which biosimilarity is determined, the rationale for extrapolation to different indications, and the evidence needed to support incorporating biosimilars into clinical practice in rheumatology.

Dr Emily Shacter explained the US Food and Drug Administration (FDA) biosimilar regulatory process, focussing on the importance of structural and functional analyses to characterise protein products and demonstrate molecular similarity. Prof Craig Leonardi, a dermatologist, discussed the rationales for the choice of an adequate patient population and disease setting in studies confirming biosimilarity. The issues around extrapolation to other indications not studied in clinical trials with the biosimilar were discussed; extrapolation being based on the same mechanism of action; the totality of the evidence of all analytical, non-clinical, and clinical data; and a thorough scientific justification based upon an extensive understanding of the safety and efficacy profile of the reference product. Prof Peter Taylor explored the impact of biosimilars on the clinical landscape of rheumatology, the potential benefits of cost and access, and recommendations for their optimal use. The symposium concluded with a question and answer session.
Deciphering Ectopic Calcification: Contribution of the Rare, Inherited Disorder Pseudoxanthoma Elasticum
Authors: Pasquali Ronchetti Ivonne
Published: April 2023

Soft connective tissue calcification is still an intriguing problem due to the high number of genes, proteins, and enzymes involved in the process. Numerous epidemiological and experimental studies of the ectopic calcification associated with metabolic, inflammatory, and degenerative disorders have been performed. Moreover, in the last decade, great efforts have been made in studying the genetic disorders leading to soft connective tissue calcification, trying to understand the imbalance between pro and anti-calcifying factors in the different disorders, and why calcification occurs only in certain body regions (which often differ between the various genetic defects). The rare, inherited disorder pseudoxanthoma elasticum (PXE), which is caused by mutations in the ABCC6 gene, is an interesting model because the gene responsible is mainly expressed in the liver, whereas calcification affects peripheral soft connective tissues. It has been suggested that liver deficiency of the protein encoded by ABCC6 directly induces peripheral calcification, although, in contrast, several studies both in humans and in transgenic mice indicate that peripheral mesenchymal cells might be permanently involved in PXE calcification. In this review, the author suggests that early in development PXE cells may undergo epigenetic changes and acquire a permanent pro-calcific signature. However, given the complexity of the calcification process and the metabolic inter-exchanges among the different calcific genetic disorders, a bioinformatic approach analysing data ranging from genes to functional proteins and clinical features may complete the puzzle and provide new therapeutic perspectives in PXE, as well as in other calcific disorders.
Non-Invasive Cardiovascular Imaging for Cardiovascular Risk Assessment in Rheumatoid Arthritis
Authors: Scanlon Erin M. , Mankad Rekha , Davis III John M.
Published: April 2023

People with rheumatoid arthritis (RA) are often under-recognised as a group with elevated risk of cardiovascular (CV) disease and increased morbidity from CV events. Standard clinical risk assessment tools, which take into account traditional CV risk factors such as smoking, diabetes, hypertension, hyperlipidaemia, and family history do not accurately predict CV risk in patients with autoimmune rheumatic disorders; therefore, there is an unmet need for other methods to assess their risk. Non-invasive CV imaging is evolving as a novel clinical tool to determine subclinical atherosclerotic coronary artery disease in patients with RA. Non-invasive imaging studies, such as tests of endothelial function (i.e. reactive hyperaemia index and flow-mediated dilation) and arterial stiffness (i.e. pulse-wave velocity), have been identified as a potential means for providing accurate assessment of early CV risk in the general population and are evolving in their utility for patients with RA. These types of non-invasive imaging have the potential to eliminate the current use of invasive assessments for identification of precursors to coronary artery disease, such as coronary angiography for early endothelial cell dysfunction. By combining the expertise of subspecialists in cardio-rheumatology clinics, the expectation is to pre-emptively identify RA patients with early coronary artery disease, allowing early modification of risk factors through either medical management or lifestyle modification.
TYRO3, AXL, and MERTK Receptor Tyrosine Kinases: Is There Evidence of Direct Involvement in Development and Onset of Sjögren’s Syndrome?
Authors: Wanchoo Arun , Voigt Alexandria , Peck Ammon B. , Nguyen Cuong Q.
Published: April 2023

Sjögren’s syndrome (SjS) is a chronic, progressive, systemic, human autoimmune disease in which an auto-inflammatory process within the salivary and lacrimal glands results in loss of saliva and tear production, respectively. In-depth analyses of the autoimmune process in humans and animal models of SjS substantiates one of the more important pathoaetiological pathways: an increased level of glandular apoptosis and/or cell lysis. We have hypothesised that failure in clearance of dying cells by macrophages, dendritic cells, and neighbouring tissues results in a sustained innate inflammatory response that transitions to autoimmunity. Since the intrinsic inhibition of inflammation following phagocytosis of dying cells is a function of a family of three receptor tyrosine kinases (RTKs) known as the TAM (Tyro3, Axl, and Mertk), we put forward the following hypothesis: based on published information and analysis of our public microarray data, the failure of TAM RTK signalling, specifically in activating suppressor of cytokine signalling (SOCS) 1 and SOCS3 (which are inhibitors of immune responses), may lead to autoimmunity, and specifically, to SjS-like disease.
Surgical Management of Post-Prostatectomy Incontinence
Authors: Satyanarayan Arthi , Mooney Ryan , Singla Nirmish
Published: April 2023

Post-prostatectomy incontinence (PPI) is a common and significant issue that can affect the quality of life in men who are undergoing treatment for prostate cancer. While some patients opt for conservative management of their incontinence, many elect to undergo surgical treatment as a result of the significant impact to quality of life. The most commonly employed surgical techniques to address PPI are placement of a male sling or artificial urinary sphincter (AUS). Currently, the AUS continues to serve as the gold standard for management, with robust data concerning longitudinal outcomes available. However, in recent years, the various methods to place the male sling have emerged as viable, less complex alternatives that avoid the need for pump manipulation. In the present review, we discuss these main surgical treatment modalities for PPI, and focus on the selection criteria that may influence appropriate operative stratification of PPI patients. Indeed, an individualised, comprehensive assessment of baseline urinary function, age, radiation, prior surgeries, functional status, and other comorbidities must be considered in the context of shared decision-making between the treatment provider and the patient in determining the optimal approach to managing PPI.
Penile Enhancement Surgery: An Overview
Authors: Bizic Marta R. , Djordjevic Miroslav L.
Published: April 2023

Penile size is a frequently observed concern in men of all ages. The way in which some men see their personality is defined, appraised, or reflected by their penis, with the view that ‘bigger is better’, is termed ‘phallocentrism’. In this review article, we assess the literature and evaluate the evidence on what is ‘normal’ in relation to penile size, and evaluate techniques for penile lengthening and girth augmentation with emphasis on the possible benefits and complications of the procedures reviewed.
Symbol and Imagination in the Animation “Ponyo on the Cliff” : Focusing on Morphological Symbol as Affect and Group Theory
Authors:   The Korean Society of Culture and Convergence, Kim Youngsun , Kim Taesoo
Published: April 2023

The purpose of this thesis is to examine the narrative of images and the form of visual art in Hayao Miyazaki's “Ponyo on the Cliff” from the viewpoint of affect. For the multilateral interpretation of the worldview implied by the text, an attempt to explore the movement and shape difference of objects from the aspect of affect is necessary. The approach through the 'group theory' that generalizes the connection between these affective imagination and semantic motifs expands the meaning recognition of growth stories. As a result of examining the transformation of geometric shapes in animation pictures as a symmetrical group and exploring the correspondence between narrative connection and narrative as a permutation group, the subject matter became clearer and richer. This article has the significance of considering the narration and morphological symbols of animation in terms of the convergence of art and learning, and presenting a methodology to analyze the morphological properties as affect as a group theory.
A Study on Effective Teaching Methods of Academic Writing: Focusing on the Relationship between Step-by-Step Writing Correction and Competency Development
Authors:   The Korean Society of Culture and Convergence, Kim Hwakyung
Published: April 2023

This paper proposes a diversified strategy for efficient operation of academic writing classes by comprehensively analyzing specific operational plans, cases, and results of step-by-step writing correction. It can provide learners with an opportunity to practice improved writing by reducing the burden of the gap between the theory and practice of writing. In this way, learners can prepare for a smooth transition into future college major writing by learning the contents and forms of academic writing while participating in the entire process of step-by-step writing correction. Furthermore, based on a learner survey, this paper derives a direct relationship between writing correction and competency development in academic writing education. Applying these findings in academic writing education, the author believes, will improve the status of academic writing instruction in the face of change and innovation and it recommends a preferable direction of university writing correction.
A Study on Public Perception of Fairness in Arts Support Project: Focused on the Case of Arts Council Korea Grants for Art Project
Authors:   The Korean Society of Culture and Convergence, Park Youngjun , Kim Sunyoung
Published: April 2023

In Jun 2021 Moon Joon-yong, a media artist and the son of president Moon Jae-In received 69million won from the Arts Council Korea. This caused a social debate about the fairness of art support project. The research of the fairness perception of artists has been conducted. However the public perception of fairness has been insufficiently analyzed. Therefore, this study tries to analyze the public perception of fairnesss thereby finding solutions to social conflicts. A mixed research method was adopted for this research. The results of this study is the perception of fairness can be changed according to the view on various goals of art support. It is expected that this study will contribut to make the formation of desirable public art support policy.
A Study on the Analysis of Learners' Experience in the TMMKFL class for Non-native Korean Pre-service Teachers
Authors:   The Korean Society of Culture and Convergence, Shin Eunkyung
Published: April 2023

This study is designed to empirically analyze the learning experience of 11 non-native Korean language pre-service teachers in the TMMKFL class. TMMKFL is conducted as the first and second mock classes based on the analysis of teaching materials and teacher's guidebooks, teaching drafting, mock classes, feedback and self-assessment in order to improve the teaching expertise of pre-service teachers in the previous stage of the practicum of Korean language education. The findings show that non-native Korean pre-service teachers have improved their teaching skills through reflective reflection and class analysis during this series of processes. In addition, they are highly satisfied with the method of teaching drafting referring to teacher's guidebooks, feedback in the process, and two self-evaluation processes, even though they had difficulties in the overall process of teaching drafting and mock classes. Finally, they need to prepare for more practice before they participate in the practicum of Korean language education, and it is required that the practice is also done in other subjects.
The Effects of Openness, Mindset, and Proactive Personality on Protean Career Attitudes
Authors:   The Korean Society of Culture and Convergence, Cho Jiyeon
Published: April 2023

The purpose of this study is to analyze the effects of openness, mindset, and proactive personality on Protean's career attitude. Reliability analysis, factor analysis, descriptive statistics, and correlation analysis were conducted using the SPSS 25.0 program for 907 office workers, and multiple regression analysis was conducted to find out whether openness, mindset, and proactive personality have an effect on Protean's career attitude. As a result of multiple regression analysis, openness, growth mindset, and proactive personality all had a positive effect on protean's career attitude. In addition, a multiple regression analysis was conducted to explore the effects of openness, mindset, and proactive personality of each of the three groups of career change, turnover, and maintenance according to career change experience on protean career attitude. Based on the above research results, workers develop their careers by forming high protean career attitudes in consideration of their psychological variables, and workers with protean career attitudes in organizations can contribute to the improvement of organizational performance. Implications for organizational culture formation, managerial leadership, and coaching were derived.
A Study on Korean Auxiliary Verbs through Learner Language Analysis: Focusing on the Analysis of the Preceding Verb ‘-Eojida’
Authors:   The Korean Society of Culture and Convergence, Yoon Jongwon
Published: April 2023

The purpose of this study is to analyze the combination pattern by categorizing a list of various preceding verbs combined with '-eojida' auxiliary verbs with frequency information through large-scale learner corpus analysis. To this end, preceding verbs combined with '-eojida' were extracted from a large-scale learner octopus corpus, and the list was classified into levels, parts, and forms and presented systematically. As a result of the analysis, the learner combined more diverse preceding verbs at the advanced stage than at the intermediate level. The adjective was combined 2801 times, which is 77.08% of the total, and 843 times, which is 23.2% of the total, with only one preceding adjective “좋다.” The combination composition and characteristics preferred by learners were analyzed by presenting the combination frequency of parts and forms. It was also suggested that it is possible to access vocabulary education.
A Research on Carl Philipp Emanuel Bach’s Musical Storytelling: Shedding New Light on “The Savior”
Authors:   The Korean Society of Culture and Convergence, Lee Sunyoung
Published: April 2023

The aim of this research is to discuss the re-illumination of The Resurrection and Ascension of Jesus, the Bach’s oratorio which created in Hamburg and in Europe a syndrome by means of the overplus characteristics of emotions in the theme of “the Savior” after Pietism of the 18th century had elicited the recognition of the importance of emotions. It is to discover the kerygma of music and to identify that Bach told the stories of the gospel by means of his own musical language. The research of the works is approached by a musical analytical research method. Ultimately this research has found that the musical storytelling of “the Savior” by Bach was his own creative theory of musical composition, in which he sought for a new way within the framework of “the religious concert oratorio” genre as the concept of “the lyric oratorio” in the overplus mode of emotions. It is my hope that his musical storytelling about “the Savior” may be re-illuminated in Korean soil in times of Postmodernism.