bluuebunny/crossref_metadata_2025 huggingface dataset:
Photodynamic treatment of Staphylococcus aureus with non-iron hemin analogs in the presence of hydrogen peroxide
Authors: Sivasubramaniam Badhu , Washer Benjamin , Watanabe Yuichiro , Ragheb Kathryn , Robinson J. Paul , Wei Alexander
Published: March 2024

Photodynamic treatment of Staphylococcus aureus with non-iron hemin analogs in the presence of hydrogen peroxide acteria subjected to antiseptic or antibiotic stress often develop tolerance, a trait that can lead to permanent resistance. To determine whether photodynamic agents could be used to counter tolerance, we evaluated three non-iron hemin analogs (M-PpIX; M = Al, Ga, In) as targeted photosensitizers for antimicrobial photodynamic inactivation (aPDI) following exposure to sublethal H2O2. Al-PpIX is an active producer of ROS whereas Ga- and In-PpIX are more efficient at generating singlet oxygen. Al- and Ga-PpIX are highly potent aPDI agents against S. aureus and methicillin-resistant strains (MRSA) with antimicrobial activity (3-log reduction in colony-forming units) at nanomolar concentrations. The aPDI activities of Al- and Ga-PpIX against S. aureus were tested in the presence of 1 mM H2O2 added at different stages of growth. Bacteria exposed to H2O2 during log-phase growth were less susceptible to aPDI but bacteria treated with H2O2 in their postgrowth phase exhibited aPDI hypersensitivity, with 6-log reduction (eradication) using only 15 nM Ga-PpIX.
4D printed nanoengineered super bioactive hydrogel scaffold with programmable deformation for potential bifurcated vascular channel construction
Authors: Nain Amit , Joshi Akshat , Debnath Souvik , Choudhury Saswat , Thomas Jobin , Satija Jitendra , Huang Chih-Ching , Chatterjee Kaushik
Published: March 2024

Four-dimensional (4D) printing of hydrogel enabled the fabrication of complex scaffold geometries out of static parts. Although current 4D fabrication strategies are promising for creating vascular parts such as tubes, developing branched networks or tubular junctions is still challenging. Here, for the first time, a 4D printing approach is employed to fabricate T-shaped perfusable bifurcation using an extrusion-based multi-material 3D printing process. An alginate/methylcellulose-based dual-component hydrogel system (with defined swelling behavior) is nanoengineered with carbonized alginate (~100 nm) to introduce anti-oxidative, anti-inflammatory, and anti-thrombotic properties and shape-shifting properties. A computational model to predict shape deformations in the printed hydrogels with defined infill angles was designed and further validated experimentally. Shape deformations of the 3D-printed flat sheets were achieved by ionic cross-linking. An undisrupted perfusion of a dye solution through a T-junction with minimal leakage mimicking blood flow through vessels is also demonstrated. Moreover, human umbilical vein endothelial and fibroblast cells seeded with printed constructs show intact morphology and excellent cell viability. Overall, developed strategy paves the way for manufacturing self-actuated vascular bifurcations with remarkable anti-thrombotic properties to potentially treat coronary artery diseases.
Effects of Ligand Chemistry on Ion Transport in Two-Dimensional Hybrid Organic-Inorganic Perovskites
Authors: Wei Grace , Kaplan Alan , Zhang Hang , Loo Yueh-Lin , Webb Michael
Published: March 2024

Two-dimensional (2D) hybrid organic-inorganic perovskites are potentially promising materials as passivation layers that can enhance the efficiency and stability of perovskite photovoltaics. The ability to suppress ion transport has been proposed as a stabilization mechanism, yet effective characterization of relevant modes of halide diffusion in 2D perovskites is nascent. In light of this knowledge gap, we combine molecular dynamics simulations with enhanced sampling and experimental validation to systematically characterize how ligand chemistry in seven (R-NH3)2PbI4 systems impacts halide diffusion, particularly in the out-of-plane direction. We find that increasing stiffness and length of ligands generally inhibits ion transport, while increasing ligand polarization generally enhances it. Structural and energetic analyses of the migration pathways provide quantitative explanations for these trends, which reflect aspects of the disorder of the organic layer. Overall, this mechanistic analysis greatly enhances the current understanding of halide migration in 2D hybrid organic-inorganic perovskites and yields insights that can inform the design of future passivation materials.
Augmenting Genetic Algorithms with Machine Learning for Inverse Molecular Design
Authors: Kneiding Hannes , Balcells David
Published: March 2024

Evolutionary and machine learning methods have been successfully applied to the generation of molecules and materials exhibiting desired properties. The combination of these two paradigms in inverse design tasks can yield powerful methods that explore massive chemical spaces more efficiently, improving the quality of the generated compounds. However, such synergistic approaches are still an incipient area of research and appear underexplored in the literature. This review covers different ways of incorporating machine learning approaches into evolutionary learning frameworks, with the overall goal of increasing the optimization efficiency of genetic algorithms. In particular, machine learning surrogate models for faster fitness function evaluation, discriminator models to control population diversity on-the-fly, machine learning based crossover operations, and evolution in latent space are discussed. The further potential of these synergistic approaches in generative tasks is also assessed, outlining promising directions for future developments.
Optimization of heterogeneous continuous flow hydrogenation using FTIR inline analysis: a comparative study of multi-objective Bayesian optimization and kinetic modeling
Authors: Chai Kejie , Xia Weida , Shen Runqiu , Luo Guihua , Cheng Yingying , Su Weike , Su An
Published: March 2024

The heterogeneous continuous flow hydrogenation is pivotal in chemical research and production, yet its reaction optimization has historically been intricate and labor-intensive. This study introduces a heterogeneous continuous flow hydrogenation system specifically designed for the preparation of 2-amino-3-methylbenzoic acid (AMA), employing FTIR inline analysis coupled with an artificial neural network model for monitoring. We explored two distinct reaction optimization strategies: multi-objective Bayesian optimization (MOBO) and intrinsic kinetic modeling, executed in parallel to optimize the reaction conditions. Remarkably, the MOBO approach achieved an optimal AMA yield of 99% and a productivity of 0.64 g/hour within a limited number of iterations. Conversely, despite requiring extensive experimental data collection and equation fitting, the intrinsic kinetic modeling approach yielded a similar optimal AMA yield but a higher productivity of 1.13 g/hour, attributed to increased catalyst usage. Our findings indicate that while MOBO offers a more efficient route with fewer required experiments, kinetic modeling provides deeper insights into the reaction optimization landscape but is limited by its assumptions.
Addressing Reproducibility Challenges in High-Throughput Photochemistry
Authors: Pijper Brenda , Saavedra Lucía M. , Lanzi Matteo , Alonso Maialen , Fontana Alberto , Serrano Marta , Gómez José Enrique , Kleij Arjan W. , Alcázar Jesús , Cañellas Santiago
Published: March 2024

Light-mediated reactions have emerged as an indispensable tool in organic synthesis and drug discovery, enabling novel transformations and providing access to previously unexplored chemical space. Despite their widespread application in both academic and industrial research, the utilization of light as an energy source still encounters challenges regarding reproducibility and data robustness. Herein we present a comprehensive head-to-head comparison of commercially available batch photoreactors, alongside the introduction of the use of batch and flow photoreactors in parallel synthesis. Hence, we aim to establish a reliable and consistent platform for light-mediated reactions in high-throughput mode. Herein, we showcase the identification of several platforms aligning with the rigorous demands for efficient and robust high-throughput experimentation screenings and library synthesis.
Key-to-Lock Halogen Bond-Based Tetragonal Pyramidal Association of Iodonium Cations with the Lacune Rims of Beta-Octamolybdate
Authors: Soldatova Natalia , Radzhabov Amirbek , Ivanov Daniil , Burguera Sergi , Frontera Antonio , Abramov Pavel , Postnikov Pavel , Kukushkin Vadim
Published: March 2024

The structure-directing “key-to-lock” interaction of double -(I(III))-hole donating iodonium cations with the O-flanked pseudo-lacune rims of [β-Mo8O26]4– gives halogen-bonded iodonium–beta-octamolybate supramolecular associates. In the occurrence of their tetragonal pyramidal motifs, deep and broad -(I(III))-holes of a cation recognize the molybdate backbone, which provides an electronic pool localized around the two lacunes. The halogen-bonded I∙∙∙O linkages in the structures were thoroughly studied computationally and classified as two-center, three-center bifurcated, and unconventional “orthogonal” I∙∙∙O halogen bonds. In the latter, the O-atom approaches orthogonally the C–I(III)–C plane of an iodonium cation and this geometry diverge from the IUPAC criteria for the identification of the halogen bond
Getting the intermolecular forces correct: introducing the ASTA strategy for a water model
Authors: Mareš Jiří , Mayorga Delgado Pau
Published: March 2024

Having a force field for water providing good bulk properties is paramount for modern studies of most biological systems. Some of the most common three-site force fields are TIP3, SPC/ϵ or OPC3, providing a decent range of bulk properties. That does not mean though, that they have realistic inter- atomic forces. These force fields have been parameterized with a top-down approach, meaning, by fitting the force field parameters to the experimental bulk properties. This approach has been the governing strategy also for many variants of four- and more-site models. We test a bottom- up approach, in which the force field is parameterized by optimizing the non-bonded inter-atomic forces. Our philosophy is that correct inter-atomic forces lead to correct geometrical and dynamical properties. The first system we try to optimize with the accurately system tailored atomic (ASTA) approach is water, but we aim to eventually probe other systems in the future as well. We applied our ASTA strategy to find a good set of parameters providing accurate bulk properties for the simple three-site force field forms, and also for AMOEBA, a more detailed and polarizable force field. Even though our bottom-up approach did not provide satisfactory results for the simple three-site force fields (with fixed charges), for the case of the AMOEBA force field it led to a modification of the original strategy, giving very good intra- and inter-molecular forces, as compared to accurate quantum chemically calculated reference forces. At the same time, important bulk properties, in this study restricted to the density and diffusion, were accurately reproduced with respect to the experimental values.
Evaluation of Reinforcement Learning in Transformer-based Molecular Design
Authors: He Jiazhen , Tibo Alessandro , Janet Jon Paul , Nittinger Eva , Tyrchan Christian , Czechtizky Werngard , Engkvist Ola
Published: March 2024

Designing compounds with a range of desirable properties is a fundamental challenge in drug discovery. In pre-clinical early drug discovery, novel compounds are often designed based on an already existing promising starting compound thorough structural modifications for further property optimization. Recently, transformer-based deep learning models have been explored for the task of molecular optimization by training on pairs of similar molecules. This provides a starting point for generating similar molecules to a given input molecule, but has limited flexibility regarding user-defined property profiles. Here, we evaluate the effect of reinforcement learning on transformer-based molecular generative models. The generative model can be considered as a pre-trained model with knowledge of the chemical space close to an input compound, while reinforcement learning can be viewed as a tuning phase, steering the model towards chemical space with user-specific desirable properties. The evaluation of two distinct tasks - molecular optimization and scaffold hopping - suggest that reinforcement learning could guide the transformer-based generative model towards the generation of more compounds of interest. Additionally, the impact of pre-trained models, learning steps and learning rates are investigated.
Analysis of Citizen Participation in Urban Planning of Comala, Colima, Mexico – A Secondary Publication
Authors: Cardenas Aguilar Amallinaly G. , Chung Alonso Peter , Cuevas Muñiz Alicia , Correa Fuentes Dora , Barajas Avalos Ignacio
Published: March 2024

The objective of this study was to determine the degree of citizen participation in urban planning processesin the municipality of Comala, Colima, Mexico to have a broader vision of the citizens and the environment in which they live. An instrument was designed specifically to perform this study and the instrument was validated by calculating Cronbach’s Alpha. The results showed that citizens were highly involved in issues concerning their urban environment, and the main problems of the public spaces were also identified.
Caracterización de la formación académica ofrecida por diez programas de formación docente en lenguas extranjeras en Colombia
Authors: Pérez Gómez Francisco Antonio , Wilson Alejandro Pérez Segura , Romero Molina Paola Ximena
Published: March 2024

Este estudio cualitativo descriptivo busca caracterizar 10 de las 35 universidades colombianas que ofrecen programas de pregrado, ya sea en bilingüismo o lenguas extranjeras, en cuanto a la formación académica que buscan desarrollar en sus egresados. Con esta indagación se pretende establecer un panorama general del tipo de formación académica brindada por instituciones que ofrecen programas similares a ÚNICA. Conocer esta información ampliaría el horizonte de formadores de educadores y de formadores en investigación en cuanto a las habilidades y competencias requeridas en formación docente de lenguas. Para llevar a cabo el respectivo análisis de documentos de acceso público y páginas web de las universidades, se emplearon los principios del análisis de contenido así: primero se determinó el objeto o tema de análisis, se enunciaron las reglas de codificación, se identificó el sistema de categorías y, por último, se comprobó la fiabilidad del sistema de codificación. Tras el análisis, se encontró que el perfil de formación académica de la mayoría de las universidades consideradas en el estudio propende por el desarrollo de competencias laborales. De la misma manera, se evidenció una inclinación por la competencia global y las competencias interculturales. Asimismo, se halló un interés de las instituciones por cultivar las competencias reflexivas y metacognitivas. Además, hubo una tendencia hacia la formación en competencias propositivas y tecnológicas. Por último, se observó una presencia, a menor escala, de competencias como la resolución de problemas, de pensamiento crítico e interdisciplinares. Por efectos de practicidad, este documento solo cubrirá la competencia global y las competencias interculturales.
ANKARA MİLLİ KÜTÜPHANE YAZMALAR KOLEKSİYONUNDAKİ 125 NUMARALI CÖNK HAKKINDA BİR İNCELEME
Authors: TEK Recep , OKTAY Adnan
Published: March 2024

Cönkler, Türk kültürü özelinde Türk halkbiliminin en önemli yazılı kaynaklarındandır. Bilhassa Âşık edebiyatı mensuplarının şiirlerini ihtiva etmesi ve bu ürünlerin kayıt altına alınıp geleceğe aktarılmasında cönkler büyük bir öneme sahiptir. En eskisi XV. yüzyıla ait olan cönklerin XVI. ve XVII. yüzyıllarda sayıları giderek artmıştır. Bilhassa XVIII. asrın ikinci yarısından XIX. yüzyılın sonuna kadar çok sayıda cönk yazılmıştır. Bugün yazma eser kütüphanelerinde muhafaza edilen ve elektronik ortamda araştırmacıların hizmetine sunulmuş olan cönklerin büyük bir kısmının XVIII. ve XIX. yüzyıllara ait olduğu görülmektedir. Cönkler üzerine yapılacak çalışmalar, kaynaklarda ismi geçmeyen birçok âşığın ve eserinin gün ışığına çıkmasına, ilgili şair ve şiirlerin şöhretinin tespitine yardımcı olmaktadır. Bu tür çalışmalar, cöngü tasnif ya da tertip edenlerin şahsında dönemin edebi zevk ve ilgisinin ortaya konulmasına da katkı sunmaktadır. Cönklerle ilgili yapılan çalışmalar, nadir şiirleriyle kaynaklarda zikredilen âşıkların yeni şiirlerinin tespitinde önemli kaynak görevi görmektedir. Böylece cönkler, bir yandan ilgili şairler hakkında daha sağlıklı tespit ve değerlendirmeler yapmaya katkı sunarken öte yandan söz konusu literatürün de güncellenmesine zemin hazırlamaktadır.

Bu makale Ankara Milli Kütüphane Yazmalar Koleksiyonunda 06 Mil Yz Cönk 125 demirbaş numarası ile kayıtlı olan cönk hakkında inceleme yapmak amacıyla hazırlanmıştır. Çalışmada araştırma, yazma eser okuma, inceleme ve analiz yöntemleri kullanılmıştır. İçindeki tarihlerden hareketle eserin istinsah tarihi 1881 olarak tahmin edilmektedir. Cöngün müstensihi ya da mürettibi hakkında herhangi bir bilgiye ulaşılamamıştır. Cönkte Ahmedî, Erzurumlu Emrah, Dertli, Âşık Ömer, Gevherî, İzzet, Karacaoğlan, Meftûnî, Sırrî, Abdullah, Nuri, Nazmî, Kerem, Süleyman, Gulâmî ve Yûnus Emre’nin şiirleri bulunmaktadır. Cönkte nazım şekillerinden en fazla koşma, gazel, nazım, dörtlük ve müstakil beyitler yer almaktadır. Cönkte bazıları beyit ve dörtlük olmak üzere toplam 119 müstakil şiir tespit edilmiştir.
Razón estadística de la municipalidad de Yxmiquilpan, 1826
Authors: Ramirez Calva Verenice Cipatli
Published: March 2024

El motivo de las presentes líneas es presentar el manuscrito titulado Razón estadística de la municipalidad de Yxmiquilpan, elaborado en 1826 por el entoncessubprefecto del distrito de Ixmiquilpan, Pedro Aviay.1 Se trata de un documento de gran valor histórico porque constituye una descripción de esa municipalidad en diversos aspectos: económico, social, climatológico, topográfico, productivo, educativo y de comunicaciones. Luego del padrón de Revillagigedo de 1791,2 que contiene una descripción de la jurisdicción, no contamos con un instrumento semejante que dé una panorámica del lugar y sus habitantes.3 En las siguientes líneas indagamos las razones que llevaron a Aviay a elaborar la Razón estadística, luego hacemos un breve recuento de los datos que contiene y posteriormente presentamos la transcripción paleográfica del mismo
PENYULUHAN PEMBUATAN AMELIORAN SEBAGAI BAHAN PEMBENAH TANAH DI DESA PEMENANG BARAT
Authors: Astiko Wahyu , Fauzi M. Taufik , Sudantha I Made , Sudirman Sudirman , Ernawati Ni Made Laksmi , Muthahanas Irwan
Published: March 2024

Pemenang Barat Village is one of the villages in the North Lombok Region whose land is dominated by sandy soil, has a dry climate and low rainfall. This sandy soil is porous, poor in nutrients and organic matter. This condition causes plant growth and yield to be low and can even cause harvest failure. Through this community service activity, "Instruction on the Making of Ameliorant as a Soil Improvement Material has been carried out in the West Pemenang Village". Activity methods are lecture, discussion, question and answer, demonstration and practice. This extension activity went well, the extension participants were active and enthusiastic in participating in the discussion. The results of this counseling can be concluded that there has been an increase in participants' understanding and skills regarding making ameliorant as a soil improver that can increase soil fertility.
PENGENALAN MODEL PEMBELAJARAN GAME BASED LEARNING DI SEKOLAH SATU ATAP (SATAP) DESA PULAU MARINGKIK MELALUI PROGRAM KONTRIBUSI SOSIAL PERTUKARAN MAHASISWA MERDEKA 3 (PMM 3) INBOUND UNIVERSITAS MATARAM TAHUN 2023
Authors: Munir Ahmad Mubarak , Ayuningsih Adinda Noura , Hardiansyah Kelfin , Syahra Tasya Alvianka , Yusriah Halimatul
Published: March 2024

Sektor pendidikan di wilayah Tertinggal, Terdepan, dan Terluar (3T) menghadapi beberapa persoalan utama antara lain prasarana, kualitas tenaga pendidik, dukungan infrastruktur, dan jumlah tenaga pengajar. Pulau Maringkik adalah salah satu pulau terluar yang menghadapi permasalahan di atas, kondisi geografis yang terpisah dari daratan Pulau Lombok mendatangkan tantangan tersendiri untuk mobilitas tenaga pendidik dan fasilitas pendukung untuk sekolah. Intervensi model pembelajaran untuk meningkatkan mutu pendidikan dan minat belajar peserta didik menjadi kebutuhan tersendiri. Mahasiswa Program Pertukaran Pelajar PMM 3, melalui kegiatan kontribusi sosial memperkenalkan model pembelajaran berbasis permainan (game based-learning) di Sekolah Satu Atap, Pulau Maringkik. Tujuan dari kegiatan ini antara lain adalah memberikan alternatif model pembelajaran berbasis permainan yang dapat disesuaikan dengan sekolah di wilayah pesisir dan kepulauan. Pelaksanaan kegiatan ini dilakukan melalui 5 tahapan yaitu persiapan, perencanaan, analisis kebutuhan, pelaksanaan program dan evaluasi kegiatan. Kegiatan ini mampu meningkatkan antusiasme peserta didik dalam proses pembelajaran, Gerak Irama dan Gerak Irama Mengenal Arah merupakan jenis permainan yang digunakan dalam mendorong minat belajar peserta didik di Gili Maringkik.
The role of silver nanoparticles biosynthesized from Citrus aurantium Leaves in some Vegetative and physiological characteristics of fenugreek plant (Trigonella foenum- graecum L.)
Authors: HUDA S. Qasim  , WIDAD. J. ATIA
Published: March 2024

The research was crried out in the plant tissue culture laboratory and the green house of Department of plant Biotechnology in College of Biotechnology/AL-Nahrain University. The aim of it, is the Green-synthesis of silver nanoparticles by using an aqueous extract of Citrus aurantium leaves and characterizied the silver nanoparticles, using visible method depend on colour changing of the solution(mixture of aqueous extract of C. aurantium leaves and 1mMol of AgNO3 under 60C ̊), UV-Visible spectroscopy method and Atomic Force Microscopy (AFM), then study the effects of foliar spray of of AgNPs on some vegetative and physiological characteristics of Fenugreek Plant (Trigonella foenum- graecum L.), such as fresh and dry weight, length of shoot, carbohydrates, proteins and proline. The result showed the positive effect of using AgNPs on these characteristics.
Survey of emerging technologies and return on investment in oil palm business in south-south states of Nigeria
Authors: Henry Agomate OBOKARE  , Felix Odemero ACHOJA  , Solomon ENIMU
Published: March 2024

The difference between the oil palm business in developed economy like Malaysia and that in less developed economy like Nigeria can be traced to technological advancement. Therefore there is continuous search for production and processing technologies that can drive development of the oil palm value chain. The broad objective of the study was to investigate the effect of innovative technologies on performance of oil palm business in South-South geo-political States of Nigeria. The study employed a multi-stage sampling procedure. Well validated structured questionnaires were used as instrument for data collection. Collected data were analysed using descriptive and inferential statistical tools such as mean, Percentage, Standard Deviation, Frequency Distribution Table, enterprise budgeting, and ordinary least square regression analysis. Socioeconomic characteristics of operators were diverse, with a predominance of young, married, male farmers (60.9%) engaged in small-scale production (mean farm size: 13.2 hectares). Traditional tools still dominated harvesting, but hydraulic press (adopted by 71.1%) and automated mills (5.3%) were adopted for processing. Value addition was substantially improved by processing technology and harvesting equipment in the South-South States of Nigeria. The study concluded that appropriate innovative technologies positively impacted profitability, efficiency, product quality, sustainability, and competitiveness. Training, subsidies and robust extension services to promote adoption of innovative technologies in the South-South States of Nigeria were recommended. The study has contributed to existing body of knowledge by affirming the central role of innovation in profit function and sustainability in the oil palm sector.
Global health and environmental sustainability
Authors: CHIBUISI FRANCS OGBUKA  , NGOZI O IZUCHUKWU  , OGWO ELISHA UKO  , OGECHI JULIANA OGBODO  , OBI VICTORY IJEOMA
Published: March 2024

The evolving trend at which the wellbeing of the human population at the world level is being studied, researched and practiced seems to be of double edged sword. Since one way to score global health and environmental sustainability is through measuring the prevalence of various global diseases in the world and their threat to decrease life expectancy in the present day as well as availability of natural resources. There is there fore need to re-evaluate the current trends, as well as proffer lasting solutions. To make a land mark success on present needs without compromising on future generation needs, there should be evolutionary and swift transformation in health for all programs, imbibing green choice life / eco-friendly production and consumption, urban farming. Thus, global health and environmental sustainability should be summed up as the study and application of attaining welfare equity for all people in a sustainable environment.
Thalamic aphasia and SARS-CoV-2 infection (COVID-19)
Authors: Marcos Altable  , Muhammad Akram
Published: March 2024

Damage to the thalamus that results in thalamic aphasia, a language disability, is typically associated with vascular events, tumours, or degenerative disorders. There is growing interest in examining the relationship between COVID-19 and thalamic aphasia due to its association with several neurological problems, including strokes and minor lesions that may affect the thalamus. The virus's ability to induce hypercoagulable states and systemic inflammation, which may result in thalamic ischemic strokes and interfere with language processing networks, has sparked this interest. In light of the COVID-19 pandemic's continuous nature, more investigation is necessary to fully comprehend the virus's neurological effects, particularly any potential connections to thalamic aphasia, in order to diagnose and treat thalamic aphasia, forecast language recovery, and customise rehabilitation plans for those affected, including those recuperating from COVID-19-related neurological complications.
Ensino multilíngue e letramento para pessoas privadas de liberdade
Authors: Gomes Sandro José
Published: March 2024

Este trabalho tem como objetivo fazer uma análise da influência da participação na remição por leitura na forma como ocorre o processo de letramento e ensino multilíngue dentro do contexto carcerário. A investigação busca responder ao problema de pesquisa: até que ponto a proposta de leitura de obras bilíngues/multilíngues na remição por leitura é fator de motivação na aprendizagem de Língua Inglesa, Língua Espanhola, dentre outras? Quanto a metodologia, a pesquisa foi descritiva e de natureza qualitativa e consistiu numa pesquisa bibliográfica e documental. Dentre os documento analisados estão Portaria do Poder Judiciário e Projeto de Remição Bilingue/Multilíngue elaborado a partir dos dados de uma pesquisa do Estágio Pós-doutoral do Programa de Pós-Graduação em Crítica Cultural da Universidade do Estado da Bahia (UNEB) que trabalhou em 2022 aspectos referentes a inclusão através da leitura de obras literárias e produção textual na prisão; além dos relatórios trimestrais das atividade educacionais implementadas na unidade prisional que possibilitam uma melhor compreensão da elaboração e implementação de uma proposta de leitura de obras bilíngues/multilíngues. Os resultados apontam que o letramento proposto no Projeto de Remição ocorre em diferenciados níveis e a participação na remição por leitura é fator de motivação para aprendizagem de uma língua estrangeira no âmbito da unidade prisional pesquisada, havendo uma correspondência entre a língua estrangeira (inglês ou espanhol) do romance escolhido e a língua pretendida no exame a ser prestado (ENEM e ENCCEJA).
Reseña de la “Colección narrativas, autobiografias y educación”
Authors: Suaréz Daniel Hugo , Fiorino María Lucía
Published: March 2024

Obras colectivas, experiencias, reflexiones, argumentos, conversaciones y escritos en colaboración horizontal son algunos de los elementos que conforman la serie “COLECCIÓN NARRATIVAS, AUTOBIOGRAFÍAS Y EDUCACIÓN”, editada por la Subsecretaría de Publicaciones y dirigida por Daniel Suárez del Instituto de Investigaciones en Ciencias de la Educación de la Facultad de Filosofía y Letras de la Universidad de Buenos Aires. La Colección forma parte de una serie de publicaciones que promueve la Facultad a través del “libre acceso” a sus obras, con el fin de democratizar el saber producido mediante la distribución libre y gratuita a través de medios digitales.
Leitura literária digital
Authors: Oliveira Daniela Pereira de , Santos Jeane de Cássia Nascimento
Published: March 2024

O presente artigo objetiva discutir as novas formas de conceber o ensino da leitura sob a perspectiva do letramento literário no ambiente virtual, apresentando uma proposta de intervenção que considerou os limites e as complexidades dos leitores digitais quanto à apropriação da linguagem cibernética. Tendo como base principal a pesquisa-ação (THIOLLENT, 2002), o trabalho em campo proporcionou aos alunos de uma escola pública de São Cristóvão/SE vivenciar uma experiência de leitura baseada no letramento literário de Cosson (2014; 2016) através da análise e do contato com contos reconhecidos como clássicos da literatura popular de tradição oral. A fundamentação teórica empregada assenta-se também nos aportes teóricos postulados por Xavier (2013), evidenciando os desafios da escola diante da aprendizagem hipertextualizada; por Coscarelli; Novais (2010) ao apontarmos a complexidade do processamento da leitura no ambiente digital pelos leitores; por Rojo (2012) e Freitas (2011) acerca dos multiletramentos e letramento digital. Assim, a tentativa de aliar a tecnologia ao ensino da leitura, tomando como diretriz as premissas de base, foi criado o App ConteConto, ferramenta usada no smartfone, com sistema operacional Android que possibilita a aprendizagem à distância. A partir da experiência com o aplicativo nas oficinas on-line de leitura, um caderno literário digital foi elaborado com o intento de auxiliar educadores no trabalho com contos. A presente análise possibilita a reflexão sobre práticas do ensino da leitura diante do advento da cibercultura.
Temperature effect of microwave heating of cured structural epoxy-carbon-filled plastic on interlayer shear stresses
Authors:   Yuri Gagarin State Technical University of Saratov, Zlobina I. V. ,   National Research Center «Kurchatov Institute», Bekrenev N. V. ,   Yuri Gagarin State Technical University of Saratov, Morozov B. B. ,   P. Sukhoi Experimental Design Bureau, Public Joint Stock Company «United Aircraft Corporation» (PJSC UAC), Nasonov F. A. ,   P. Sukhoi Experimental Design Bureau, Public Joint Stock Company «United Aircraft Corporation» (PJSC UAC),   Moscow Aviation Institute (National Research University) (MAI)
Published: March 2024

Studies of changes in the limiting stresses of interlayer shear during loading of cured carbon-filled plastic after exposure to a microwave electromagnetic field with a frequency of 2450 MHz and with different energy flux densities, taking into account the thermal factor and time, have been performed. It is shown that with a rational combination of energy flux density and time, (17—18) · 104 mcW / cm2 and 2 min, respectively, the values of the limiting voltages increase by an average of 17% as compared with the reference specimens.
Is More Always Better? Evaluating Accessibility to Parks and Forests in 33 European Cities Using Sustainable Modes of Transportation
Authors: Wozniak Marcin , Radzimski Adam , Wajchman-Świtalska Sandra
Published: March 2024

Enhancing quality of life in contemporary cities hinges on convenient access to parks and forests, offering avenues for physical activity and social engagement, as well as benefits for mental health and opportunities for educational pursuits. This comprehensive study delves into the accessibility to parks and forests across 33 major European cities, employing an interdisciplinary framework drawing from transportation and urban planning methodologies. By analyzing accessibility to urban green spaces (UGS) through sustainable modes of transportation, the research aims at unveiling patterns shaped by population density, terrain elevation, city area and transportation infrastructure. Notably, disparities in accessibility emerge both within and between cities, with urban parks, typically nestled in city centers, exhibiting more equitable accessibility compared to forests, often situated on the outskirts. Further results show that the area of UGS, road network density, public transit availability, and elevation gradients influence parks and forests accessibility with different strengths and in different configurations, unveiling the complexity of green space distribution within urban landscapes. Across transportation modes, disparities in accessibility are most pronounced for pedestrians, accentuating the need for targeted interventions to bridge the gaps. The study also emphasizes the significance of discerning qualitative distinctions among diverse green spaces, advocating for tailored strategies in UGS planning. Acknowledging the pivotal role of parks in augmenting UGS accessibility, particularly in densely populated areas and for short-distance journeys, the paper underscores the urgency of fair provision. Finally, this research furnishes insights for policymakers and urban planners committed to fostering inclusive, healthy and sustainable urban environments.
Wildfire smoke exposure and mortality burden in the US under future climate change
Authors: Qiu Minghao , Li Jessica , Gould Carlos , Jing Renzhi , Kelp Makoto , Childs Marissa , Wen Jeff , Xie Yuanyu , Lin Meiyun , Kiang Mathew , Heft-Neal Sam , Diffenbaugh Noah , Burke Marshall
Published: March 2024

Wildfire activity has increased in the US and is projected to accelerate under future climate change. However, our understanding of the impacts of climate change on wildfire smoke and health remains highly uncertain. Here we quantify the mortality burden in the US due to wildfire smoke fine particulate matter (PM2.5) under future climate change. We construct an ensemble of statistical and machine learning models that link climate to wildfire smoke PM2.5), and empirically estimate smoke PM2.5-mortality relationships using georeferenced data on all recorded deaths in the US from 2006 to 2019. We project that climate-driven increases in future smoke PM2.5 could result in 27,800 excess deaths (95% confidence interval: 13,100 - 43,400) per year by 2050 under a high warming scenario (SSP3-7.0) -- a 76% increase relative to estimated 2011-2020 averages. Cumulative excess deaths from wildfire smoke PM2.5 could exceed 700,000 between 2025-2055. When monetized, climate-induced smoke deaths result in annual damages of $244 billion, comparable to prior aggregate estimates of all other economic damage due to climate change. Our research suggests that the health cost of climate-driven wildfire smoke could be among the most important and costly consequences of a warming climate in the US, and an urgent adaptation priority.
The Virtual Water Gallery: Art as a catalyst for transforming knowledge and behaviour in water and climate
Authors: Arnal Louise , Schuster-Wallace Corinne
Published: March 2024

Water is life. Water-related challenges, such as droughts, floods, water quality degradation, permafrost thaw and glacier melt, exacerbated by climate change, affect everyone. It is challenging, yet of critical importance, to communicate science on such difficult highly volatile topics. Art is a more approachable medium to traditional scientific outlets that has the potential to diversify voices at the table and to lead to more wholistic solutions to these complex challenges. Launched in 2020, the Virtual Water Gallery is a transdisciplinary science and art project of the Global Water Futures program, that aims to provide a collaborative space for dialogues between water experts, artists, and the wider public, to explore water challenges we all face. As part of this initiative, 14 artists or sci-artists representing women, men and Indigenous voices across Canada were paired with teams of Global Water Futures scientists to co-explore specific water challenges in various Canadian ecoregions and communities. These collaborations led to the co-creation of artworks exhibited online on the Virtual Water Gallery in 2021. In 2022, the Virtual Water Gallery came to life with an in-person exhibition in Canmore, Alberta, Canada. Surveys were developed to capture changes in knowledge, attitudes and water-related climate mitigation practices of visitors to this science and art online and in-person exhibition. Surveys were also developed to capture experiences of the SciArt collaboration participants. Results from the survey responses of 139 visitors hint to the significance of art in changing knowledge levels and intended behaviours related to water-related climate change mitigation, especially for visitors with low prior knowledge levels. This underscores the potential of SciArt to extend beyond communication, acting as a catalyst in the collaborative creation of new knowledge for the benefit of society. The insights gained from participant responses can serve as valuable guidance for shaping future initiatives.
Autistic traits and temporal integration of auditory and visual stimuli: The role of imagination
Authors: Tsuji Yurika , Nishiguchi Yuki , Noda Akari , Imaizumi Shu
Published: March 2024

Individuals with the autism spectrum disorder face temporal integration difficulties in some sensory modalities that may be related to imagination difficulties. In this study, we tested the hypotheses that among Japanese university students, (1) higher autistic traits and (2) greater imagination difficulties lead to correspondingly lower performance in tasks that require temporal integration. Two tasks were used to assess their temporal integration abilities: a speech-in-noise test using noise with temporal dips in the auditory modality and a slit-viewing task in the visual modality. The results showed that low performance in the speech-in-noise test was related to autistic traits and some aspects of imagination difficulties, whereas the slit-viewing task was related to neither autistic traits nor imagination difficulties. One must have the ability to temporally integrate fragments of auditory information to perceive speech in noise with temporal dips. The difficulties in perceiving sensory information as a single unified percept using priors may cause difficulties in temporally integrating auditory information and perceiving speech in noise. Furthermore, an exploratory analysis suggested that imagination difficulties predict the difficulty in perceiving speech in noise with temporal dips, which leads to social impairment.
Reviewing Genetic Insights into Depression: Exploring Polygenic Score Risk and Environmental Influences in Depression
Authors: Goktas Selin Ozlem
Published: March 2024

Depression is a prevalent and debilitating mental health condition with significant global burden. Understanding its genetic basis has become increasingly important, with the advent of polygenic scores (PGS) offering insights into the interplay between genetic predisposition and environmental factors. This review paper provides an overview of the genetic architecture of depression and introduces PGS for depression, highlighting their potential applications in research and clinical settings. We discuss the complexities of depression as a polygenic trait influenced by both genetic and environmental factors, emphasizing the importance of integrating non-genetic risk factors to improve risk prediction models. Additionally, we review key findings from studies investigating the relationship between PGS for depression and various environmental factors such as stressful life events, childhood trauma, social support, and physical activity. While the evidence on gene-environment interactions in depression remains inconsistent, emerging research suggests that certain environmental factors may exacerbate or mitigate genetic susceptibility to depression. We conclude by emphasizing the need for further research to elucidate the mechanisms underlying these interactions and to identify protective factors that can inform targeted interventions for depression. Overall, incorporating PGS for depression into research endeavors holds promise for advancing our understanding of depression etiology and improving risk assessment and intervention strategies.
Human Retinotopic Mapping: from Empirical to Computational Models of Retinotopy
Authors: Ribeiro Fernanda Lenita , Benson Noah Charles , Puckett Alexander M
Published: March 2024

Perceptual brain regions represent the world using 2D maps. In the visual cortex in particular, the 2D cortical surface represents the 2D visual field topologically. That is, adjacent neurons in the visual brain represent adjacent locations on the retina, resembling a miniature map of the outside world. Here, we review empirical and theoretical work to access and model these miniature maps in human visual cortex. We aim to present a balanced view of the foundational work of the past and the current state-of-the-art capabilities. Specifically, we discuss how empirical retinotopic mapping enabled the development of theoretical and computational models of retinotopy and, subsequently, how these models have been used to better understand the retinotopic organization of the human visual cortex. Finally, we discuss a non-exhaustive list of potential future directions to further our understanding of these visual field maps, including their structure-functional relationships, individual variability, and more.
Overt and Subtle Discrimination and Psychological Well-Being: Examining the Mediating and Moderating Role of Ethnic-Racial Identity Among Emerging Adults
Authors: Aral Tugce , Ceccon Chiara , de Moor Elisabeth Louise , Tang Yixin , Osinga Mariëlle , Fishere Mariam , Syed Moin
Published: March 2024

Ethnic-racial identity (ERI) has been reported as mediator and moderator of the relation between discrimination and psychological well-being. However, it remains unclear how different forms of discrimination (i.e., overt and subtle) predict well-being over time, and whether ERI exploration and commitment mediate or moderate this association. This preregistered study explored the associations of overt and subtle discrimination with well-being (i.e., depression, substance use, life satisfaction) in a sample of 323 ethnic-racial minoritized college students (Mage W1 = 18.03, 62.7% female) from longitudinal data collected in the US. Cross-lagged panel models across three waves indicated no associations of overt discrimination, but participants experiencing more subtle discrimination during their transition to college reported more depressive symptoms after four months. ERI did not function as mediator or moderator. Findings indicate the need for a more nuanced understanding of the role of ERI during emerging adulthood.
Facilitating Implicit Learning of Multiple Non-adjacent Dependencies Regardless of Language Experience: The Role of a Brief Pre-exposure
Authors: Ling Xiaoli , Zhang Qingyun , Sun Peng , Zhao Lu , Zheng Li , Dienes Zoltan
Published: March 2024

In natural language, multiple non-adjacent dependencies arise as syntactic complexity increases and play an essential role in generating and understanding complex syntactic structures (e.g., in cross-serial dependencies). In the lab, showing substantial learning of such dependencies is challenging. In this study, we explored whether a brief prior exposure of an easy-to-learn long distance dependency structure could facilitate the acquisition of difficult-to-learn multiple non-adjacent dependencies (Experiment 1) and whether the effect is constrained by prior long-term knowledge of such types of dependency (Experiment 2). In Experiment 1, we found that the subsequent implicit learning of the new multiple non-adjacent dependencies could benefit from brief prior exposure to learnable non-adjacent dependencies compared to Non-Learnable and Unstructured conditions (which have unreliable or neutral prior materials). This facilitative effect was neither cumulative learning over time nor a simple superimposition of the pre-exposure and exposure phases. In Experiment 2, we further found that the brief prior exposure could override biases from long-term experience to improve implicit learning of multiple non-adjacent rules which conflicted with native language experience. The results reported in both studies have been certified as computationally reproducible by an independent statistician. These findings demonstrated that implicitly acquiring multiple non-adjacent dependencies can be facilitated by brief prior exposure to a learnable structure. This powerful facilitative effect can override the constraints provided by long-term experience.
PENDAMPINGAN PENGGUNAAN APLIKASI SIAK TERINTEGRASI BUMDES BERKAH BERSAMA
Authors: Savitri Enni , Andreas Andreas , Diyanto Volta , Musfialdy Musfialdy , Hamzah Amir
Published: March 2024

Badan Usaha Milik Desa (BUMDes) memiliki peran yang sangat penting dalam pengembangan dan pemberdayaan masyarakat di tingkat desa. BUMDes memiliki peran penting dalam membangun ekonomi lokal yang kuat, meningkatkan kesejahteraan masyarakat desa, dan menciptakan lingkungan yang berkelanjutan dan inklusif. Tujuan kegiatan pengabdian melakukan pendampingan dalam menggunakan aplikasi Mobile Aplikasi SIAK Terintegrasi BUMDes Berkah Bersama di BUMDes Berkah Bersama diKabupaten Indragiri Hulu sehingga dapat meningkat pendapatan asli desa, menguatkan ekonomi desa dan kesejahteraan masyarakat desa. Pelaksanaan pengabdian ini menggunakan teknik pendampingan penerapan sistem pengelolaan unit bisnis BUMDes secara Web. Tingkat ketercapaian sasaran program diukur melalui berbagai metode evaluasi, seperti survei, wawancara, analisis data, observasi langsung. pendampingan pelaporan keuangan BUMDes berbasis web, program ini berkontribusi pada peningkatan pendapatan desa,  juga pada peningkatan tata kelola keuangan yang lebih baik dan pemberdayaan masyarakat desa. Dengan cara ini, program tersebut dapat dianggap sebagai bentuk nyata dari pengabdian kepada masyarakat untuk meningkatkan kesejahteraan dan pembangunan berkelanjutan di tingkat desa.