bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Rights in the Innovative Sustainable Socially Responsible Society (ISSRS)
Authors: Pucelj Maja , Mulej Matjaž , Hrast Anita
Published: April 2024

The upholding of fundamental human rights is essential for the survival and well-being of humanity, as emphasised by the fundamental principle of ISO 26000. Initially, corporations were encouraged to practise social responsibility (SR) willingly, without any legal requirement. However, this approach was shown to be inadequate for ensuring global sustainability and the preservation of human rights. This book chapter examines the relationship between human rights and sustainable development goals (SDGs) within the framework of a socially responsible society. It emphasises the importance of organisations integrating human rights points of view, in accordance with the 2030 sustainable development agenda. The research emphasises the urgent requirement for a forward-thinking and environmentally-friendly society dedicated to social responsibility in order to ensure the survival of humanity. This conclusion is based on a thorough examination of several documents, including academic literature and influential worldwide publications such as COP27.
Strengthening Human Rights via Distributive Health Justice and Rurality
Authors: Singh Bhupinder , Vig Komal , Dutta Pushan Kumar , Kaunert Christian , Gautam Bhupendra Kumar
Published: April 2024

The elimination of health disparities is the goal of health justice which is especially important for those who live in rural areas. The ensuring of fair access to medical services in rural areas requires providing healthcare for the populace living in these places. The rural areas frequently experience particular issues such as a lack of healthcare experts a restricted healthcare infrastructure and trouble receiving specialist care. Upholding human rights is a business entity's role and a crucial part of their corporate social responsibility. Corporate social responsibility, business and human rights concerns have different legal aspects and contents. The methodical approach to putting these ideas into practice is still the same. The chapter looks at how society views the link between these two domains and whether or not voluntary corporate social responsibility programs include human rights. In order to improve healthcare infrastructure, it focuses on creating and bolstering district hospitals, community health clinics and primary health centres.
Embarking on Virtual Journeys
Authors: Islam Md. Tariqul , Kumar Jeetesh , Hussin Siti Rahayu , Wong Foong Yee
Published: April 2024

A travel vlog is short for a travel video blog, which includes footage of the vlogger exploring different places, trying local foods, engaging in different activities, and interacting with the local culture. It plays a significant role in tourism by influencing and inspiring potential travellers. It is a powerful tool for promoting destinations, influencing travel decisions, and fostering a global community of adventure-seekers. Travel vlogs are commonly shared on video-sharing platforms such as YouTube and social media. This chapter delves into the evolutionary journey of travel vlogs, examining their roots in traditional word-of-mouth communication and their progression through electronic word-of-mouth (e-WoM), online consumer reviews (OCRs), and travel blogs. The chapter envisions the potential of virtual reality (VR) to redefine how travel stories are told and foster a deeper connection between creators and viewers. Finally, this study highlights the significance of travel vlogs in the tourism industry.
Engineering Properties of Concrete Incorporating Water Purification Sludge
Authors: Wu Chung Hao , Lin Wei Ting , Hu Shao Ting
Published: April 2024

The study aims to investigate the engineering properties of concrete incorporating water purification sludge (WPS). The design compressive strengths of concrete are 14 MPa and 21 MPa at 28 days. The rates of WPS for replacing natural aggregate are 0%, 30%, and 60%. The test results show that the slump and unit weight of fresh concrete decrease with the increase of the WPS content, and the development of concrete compressive strength and splitting strength also have the same phenomenon. The replacement ratio of WPS reaches 60%, and the ultrasonic pulse velocity is less than 3000 m/sec, meaning that the quality of the concrete is poor. Concrete with WPS has lower resistance to permeability than that control concrete, which means the durability of the concrete presents lower than that of control concrete. The concrete incorporating WPS has lower compressive strength and durability because of existing WPS particles in the interfacial transition zone around the aggregate.
Effect of Structural Breaks on Stock Market Performance during COVID-19 Period in Sri Lanka
Authors: Walakumbura S. H. M. L. , Weerasinghe W. M. S. P. , Peiris T. U. I.
Published: April 2024

This study investigates the effects of structural breaks on the Colombo Stock Exchange (CSE) performance over the COVID-19 period. Stock market returns and volatility are used to proxy the stock market performance. Structural breaks were identified by using the Bai-Perron (2003) test. An ARMA (p,q) model fitted for stock returns was augmented using dummy variables for the structural breaks to measure the effect of structural breaks on stock market returns. The model was further extended as a volatility regression model (GARCH, EGARCH, or TGARCH) to measure the effect of structural breaks on stock market volatility. The results confirmed the presence of structural breaks following COVID-19-related news in CSE. Seventeen such breaks were identified. However, only three significantly influenced the stock market returns and the volatility. As a result, the study's consequences affect stockbrokers, multinational organizations, portfolio managers, and investors, allowing them to foresee market patterns and take preventative action in the event of structural breaks.
Factors Contributing to Delayed Presentation In ST-Elevation Myocardial Infarction and Implication for In-Patient Outcomes
Authors: Sooriyagoda S. K. G. P. H. K. , Amarasinghe R. M. M. K. , Kumara H. S. R. , Jayawickreme S. R. , Abeysinghe A. H. M. T. B.
Published: April 2024

Introduction: ST-elevation myocardial infarction (STEMI) is a significant cause of mortality and morbidity among patients with ischemic heart disease. Early intervention, such as primary percutaneous coronary intervention (PPCI) or thrombolysis has been shown to improve patient outcomes. However, delayed presentation in STEMI results in larger infarct size and increased complications.Objectives: This retrospective descriptive study aimed to identify factors contributing to delayed presentation in STEMI and in-patient outcomes.Methodology: A retrospective descriptive study was conducted. All the STEMI patients who underwent primary percutaneous coronary intervention at National Hospital Kandy from February 2019 to December 2019 were studied.Results: A total of 243 STEMI patients who underwent PPCI at the National Hospital Kandy from February 2019 to December 2019 were studied. Among the study population, 31.27% were delayed presenters and 68.72% were non–delayed presenters. Atypical chest pain was identified as the main reason for a delayed presentation. Female gender was not associated with delayed presentation, contrary to the findings in other studies. Diabetes mellitus and the location of the culprit lesion did not significantly contribute to delayed presentation in this study group. Complications during hospital stay and average duration of hospital stay were not significantly different between delayed and non-delayed presenters. However, delayed presenters exhibited lower left ventricular ejection fraction on discharge, which is a critical predictor of short and long-term outcomes.Conclusions: Community awareness programs are essential to minimize pre-hospital delays in STEMI presentation. Early recognition of atypical symptoms, irrespective of gender, and timely intervention are vital for improving outcomes in STEMI patients. Further research is warranted to explore the impact of other risk factors and co-morbidities on the duration of presentation in STEMI patients.
Sri Lankan Newborns; Improving Survival and Well-Being
Authors: Gunawardane D. A.
Published: April 2024

No abstract available
NK Cell–Monocyte Cross-talk Underlies NK Cell Activation in Severe COVID-19
Authors: Lee Madeline J , de los Rios Kobara Izumi , Barnard Trisha R , Vales Torres Xariana , Tobin Nicole H , Ferbas Kathie G , Rimoin Anne W , Yang Otto O , Aldrovandi Grace M , Wilk Aaron J , Fulcher Jennifer A , Blish Catherine A
Published: April 2024

NK cells in the peripheral blood of severe COVID-19 patients exhibit a unique profile characterized by activation and dysfunction. Previous studies have identified soluble factors, including type I IFN and TGF-β, that underlie this dysregulation. However, the role of cell–cell interactions in modulating NK cell function during COVID-19 remains unclear. To address this question, we combined cell–cell communication analysis on existing single-cell RNA sequencing data with in vitro primary cell coculture experiments to dissect the mechanisms underlying NK cell dysfunction in COVID-19. We found that NK cells are predicted to interact most strongly with monocytes and that this occurs via both soluble factors and direct interactions. To validate these findings, we performed in vitro cocultures in which NK cells from healthy human donors were incubated with monocytes from COVID-19+ or healthy donors. Coculture of healthy NK cells with monocytes from COVID-19 patients recapitulated aspects of the NK cell phenotype observed in severe COVID-19, including decreased expression of NKG2D, increased expression of activation markers, and increased proliferation. When these experiments were performed in a Transwell setting, we found that only CD56bright CD16− NK cells were activated in the presence of severe COVID-19 patient monocytes. O-link analysis of supernatants from Transwell cocultures revealed that cultures containing severe COVID-19 patient monocytes had significantly elevated levels of proinflammatory cytokines and chemokines, as well as TGF-β. Collectively, these results demonstrate that interactions between NK cells and monocytes in the peripheral blood of COVID-19 patients contribute to NK cell activation and dysfunction in severe COVID-19.
Association between lifestyle and skin moisturizing function in community-dwelling older adults
Authors: Oizumi Ryosuke , Shibata Rie
Published: April 2024

The skin moisturizing function decline with age, leading to skin dryness in approximately 40% of the olderly. Various lifestyle habits may affect the skin moisturizing function, however it is not clear which ones are particularly relevant. A cross-sectional study was conducted between September and December 2023, involving individuals aged 65 years and older. Self-administered questionnaire were employed to collect information on lifestyle habits. Stratum corneum hydration (SC hydration), as an indicator of skin hydration, was measured and analyzed using multiple regression. A total of 124 individuals participated in the study, with a mean age of 83.6 years. Daily use of moisturizer (p=0.024) and activity level (p=0.002) demonstrated significant associations with increased SC hydration. Although not statistically significant, smoking exhibited a trend towards decreased SC hydration (p=0.173). The findings of this study suggest that, among various lifestyle habits, exercise and daily moisturizing contribute to enhanced SC hydration. These results suggest that lifestyle modifications may improve the skin moisturizing function of olderly.
Outcome of combined anatomic reconstruction of the anterior cruciate ligament with anterolateral ligament reconstruction versus with iliotibial band tenodesis
Authors: Hassan Alaa Zenhom Mahmoud , Zein Assem M Noureldin
Published: April 2024

Background

Isolated anterior cruciate ligament (ACL) tears without anterolateral structures injuries are treated successfully by isolated reconstruction of ACL. However, most ACL injuries are associated with the injuries of anterolateral stabilizers of the knee; mainly the iliotibial tract (ITB) and the anterolateral ligament (ALL). If ACL is only reconstructed in such a case, the incidence of postoperative rotational instability reaches 18%. New directions guided towards combined ACL reconstruction with extraarticular anatomical and nonanatomical reconstructions to improve knee rotation and translation and prevent pivot shift phenomena.

Patients and methods

We retrospectively reviewed all patients operated on for combined injuries of ACL and anterolateral stabilizers from February 2019 to February 2021. Preoperatively and postoperatively, all patients were examined clinically by knee stability tests: anterior drawer, Lachman, and pivot shift tests, applying the International Knee Documentation Committee score and return time to the sport.

Results

Forty patients were included with a mean age of 28 ± 8.33 years (range, 18–44 years). Patients were divided into two groups, group A 20 patients (18 males and two females) were treated by combined ACL with ALL reconstruction, and group B 20 patients (18 males and two females) were treated by combined ACL with ITB tenodesis. Sports injuries were the cause in 15 patients in group A and 14 in group B, while five injuries were due to nonsport activity in group A and six in group B. The mean follow-up period was 33.5 ± 2.1 months. Median postoperative subjective International Knee Documentation Committee scores in groups A and B were 95.4 and 94.25, respectively, without any statistically significant difference. Group A shows better postoperative improvement in pivot shift and one-leg hop test than group B with a significant difference (P<0.05).

Conclusion

No significant difference between ALL reconstruction or ITB tenodesis with ACL reconstruction according to subjective knee functions but there was a significant difference according to objective functions, also lateral knee pain was reported in group B and not observed in group A.
Anterior cruciate ligament reconstruction using peroneus longus tendon autograft: a systematic review
Authors: Ghonim Samir S , Hemida Mohamed A , Khater Ahmad H
Published: April 2024

Background

The anterior cruciate ligament is the most commonly injured ligament in the knee; controversy exists about the most suitable graft for anterior cruciate ligament reconstruction (ACLR).

Aim

This study aims to assess the efficiency of peroneus longus tendon (PLT) autograft as a good alternative graft choice for ACLR and to outline the advantages and disadvantages of its use.

Methodology

We searched the literature through PUBMED, Cochrane library, Medscape, direct science, JBJS, and Google scholar with publication date restricted to 10 years range from 2012 to 2022. English literature of prospective studies only were selected with strict inclusion criteria where human studies undergoing arthroscopic ACLR using PLT autograft, which commenting on clinical±imaging outcomes and repeated studies excluded. Eleven studies were included satisfying the predetermined inclusion criteria with a total of 564 patients. Four literatures compared ACLR using PLT autograft versus Hamstring tendon (HT), one literature versus semitendinosus graft, and another versus patellar tendon. After pooling collected data from the desired search studies, the relative risk of each of the intended outcome measures of interest was calculated and tabulated according to IKDC and AOFAS scores.

Results

In four literatures, in total, outcomes of 108 PLT versus 129 HT autografts were analyzed with mean follow-up 10.5 months, reported little difference was found between the two grafts in favor of PLT autograft, with mean score 95.58 for PLT versus 91.65 for HT. Outcomes of 15 PLT versus 15 semitendinosus autografts were analyzed. PLT autograft gave better clinical and biomechanical outcomes than semitendinosus graft as mean IKDC score was 91.58 for PLT versus 88.37 for semitendinosus graft. Outcomes of 50 PLT versus 50 patellar tendon autografts were analyzed, and reported that PLT autograft has a better IKDC score than patellar tendon autograft (96.8 vs. 95.1) and lower graft rupture rate (6 vs. 10%). In five literatures, in total, the outcomes of 189 patients had ACLR using PLT autograft, were analyzed after mean follow up 12.4 months and revealed that mean IKDC score was increased from 64.7 preoperative to 97.8 postoperative. PLT harvest does not appear to affect foot and ankle function to any clinically significant degree with slightly decreased AOFAS score (96.88 ± 4.95).

Conclusion

PLT autograft consider a very promising and ideal graft option for ACLR with excellent functional and biomechanical outcomes. PLT harvest is easy and causes minimal donor-site morbidity.
Prospective Study of the Incidence of Asymptomatic Deep-vein Thrombosis in Postoperative Patients: A Single-center Study
Authors: Agarwal Vivek , Ramakrishnan Dileep , Majumdar Sumantra Shekher , Dwivedi Surjeet Kumar , Dwivedi Sabita
Published: April 2024

Introduction:

Postoperative DVT remains one of the formidable challenges for the surgeon. It is associated with a significant risk of associated morbidity and mortality. Diagnosis of DVT is usually established by the combination of symptoms and imaging, which is most commonly performed noninvasively by color Doppler. However, in multiple instances, the patient may remain asymptomatic, and hence, the diagnosis may be missed.

Aim and Methodology:

This study was performed at tertiary care to study the incidence of asymptomatic DVT in postoperative patients across various specialties. All postoperative patients were subjected to color Doppler on the 1st, 7th, and 30th postoperative days.

Results:

Out of 300 patients who were part of the study over 1 year, 31 patients developed DVT, of which eight were symptomatic. They all were managed as per any other patient of DVT by anticoagulants, class II stockings, and limb elevation. We had no mortality.

Conclusion:

DVT may develop in postoperative cases. It may be fatal if not recognized and treated in time. Timely diagnosis and adequate management remain key in avoiding morbidity and mortality. Data related to postoperative patients developing asymptomatic DVT are limited. There seems to be ambiguity in its etiology, prognosis, management protocol, and follow-up.
Retained Inferior Vena Cava Filter Retrieval: Novel Approach Using Tiger Tooth Foreign Body Holding Forceps
Authors: Balachandran Saravanan , Omprakash Shanmuganandam , Rajkumar Murugesan , Prakash Junia
Published: April 2024

Only about one-third of all inferior vena cava (IVC) filters are successfully retrieved. This is largely due to factors such as IVC occlusion, filter tilt, and caval wall penetration among other reasons. IVC filter retrieval methods currently followed in practice involve the use of standard snares and wires, endobronchial forceps, LASER-tipped sheaths, and even open surgery. However, the success rate of filter retrieval continues to remain low, thereby increasing the risk of complications associated with retained IVC filters. This warrants a need to explore and adopt newer techniques of IVC filter retrieval. In this case report, we describe the novel use of a tiger tooth foreign body holding forceps in the successful retrieval of a retained IVC filter in an elderly man with intracranial hemorrhage.
Treating amyotrophic lateral sclerosis with allogeneic Schwann cell–derived exosomal vesicles: a case report
Authors: Goldschmidt-Clermont Pascal J. , Khan Aisha , Jimsheleishvili George , Graham Patricia , Brooks Adriana , Silvera Risset , Goldschmidt Alexander J.P. , Pearse Damien D. , Dietrich W. Dalton , Levi Allan D. , Guest James D.
Published: April 2024

Schwann cells are essential for the maintenance and function of motor neurons, axonal networks, and the neuromuscular junction. In amyotrophic lateral sclerosis, where motor neuron function is progressively lost, Schwann cell function may also be impaired. Recently, important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been reported. This case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles, marking, to our knowledge, the first instance of such treatment. An 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral sclerosis. After initial diagnosis, the patient underwent a combination of generic riluzole, sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis, and taurursodiol. The patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron function. We confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired (senescent) and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles, cultured expanded from a cadaver donor improved their growth capacity in vitro. After a period of observation lasting 10 weeks, during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored, the patient received weekly consecutive infusions of 1.54 × 1012(×2), and then consecutive infusions of 7.5 × 1012(×6) allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered saline. None of the infusions were associated with adverse events such as infusion reactions (allergic or otherwise) or changes in vital signs. Clinical lab serum neurofilament and cytokine levels measured prior to each infusion varied somewhat without a clear trend. A more sensitive in-house assay suggested possible inflammasome activation during the disease course. A trend for clinical stabilization was observed during the infusion period. Our study provides a novel approach to address impaired Schwann cells and possibly motor neuron function in patients with amyotrophic lateral sclerosis using allogeneic Schwann cell-derived exosomal vesicles. Initial findings suggest that this approach is safe.
Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients: a rare occurrence?
Authors: Martinelli Ilaria , Mandrioli Jessica , Ghezzi Andrea , Zucchi Elisabetta , Gianferrari Giulia , Simonini Cecilia , Cavallieri Francesco , Valzania Franco
Published: April 2024

Amyotrophic lateral sclerosis (ALS) is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex, brainstem, and spinal cord. While the typical clinical phenotype of ALS involves both upper and lower motor neurons, human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions, expanding the phenotype of ALS. Although superoxide dismutase 1 (SOD1) mutations represent a minority of ALS cases, the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized therapies. Despite numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1 (SOD1-ALS), no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this subpopulation. In this narrative review, we analyze and discuss the available literature on extrapyramidal and non-motor features during SOD1-ALS. The multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms, pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.
Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance
Authors: Ntetsika Theodora , Catrina Sergiu-Bogdan , Markaki Ioanna
Published: April 2024

Type 2 diabetes mellitus and Parkinson’s disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden. Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular mechanisms. Impaired insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson’s disease through the dysregulation of several pathological processes. The contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson’s disease, with emphasis on brain insulin resistance, is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed.
Effectiveness and safety of regimen containing bedaquiline and delamanid in patients with drug-resistant tuberculosis
Authors: Putra Oki Nugraha , Yulistiani Yulistiani , Soedarsono Soedarsono , Subay Susi
Published: April 2024

Background:

Bedaquiline and delamanid have been included in the individualized treatment regimen (ITR) to treat patients with drug-resistant tuberculosis (DR-TB).

Objective:

The objective of this study is to compare the effectiveness of sputum culture conversion and the safety of ITR containing bedaquiline and delamanid.

Methods:

Data were collected retrospectively from medical records of DR-TB patients who received ITR between January 2020 and December 2021. Patients were divided into bedaquiline and bedaquiline-delamanid groups. Sputum culture was evaluated until 6 months of treatment. Measurement of QTc interval, renal and liver function test, and serum potassium were evaluated to assess safety during the study period. We used Chi-square to analyze a difference in cumulative culture conversion; meanwhile, Wilcoxon and Mann–Whitney tests were used to analyze differences in laboratory data for each and between the two groups, respectively.

Results:

Fifty-one eligible DR-TB patients met the inclusion criteria, 41 in the bedaquiline and 10 in bedaquiline-delamanid group. 43/51 patients had a positive culture at baseline. After 6 months of treatment, 42/43 DR-TB patients (97.6%) had sputum culture conversion and no difference between the two groups (P≥ 0.05). QTc interval within normal limit and no patient had a QTc >500 ms during the study period. Creatinine levels significantly differed between the two groups 6 months after treatment (P< 0.05).

Conclusion:

DR-TB patients who received all oral ITR containing bedaquiline and or delamanid demonstrated favorable sputum conversion with a tolerable safety profile.
Lip vitiligo: a clinico-epidemiological study in a tertiary hospital of South India
Authors: Savitha A. S. , BM Shashi Kumar , R Raghunatha Reddy , Sankey Sana Mariam
Published: April 2024

Vitiligo is a common autoimmune pigmentary disorder characterized by destruction of functional melanocytes resulting in the appearance of depigmented patches on the skin and mucosa. These lesions pose a cosmetic challenge. The involvement of the mucosa is less, but may be the first symptom of this pathology. Depigmentation in the lips can be more easily observed and patients can be counseled regarding the condition and guided for treatment. Aims: The study describes the various clinic-epidemiological factors associated with lip vitiligo. Materials and Methods: The study sample included 100 patients of lip vitiligo of all age groups and gender. Patients with a history of herpes labialis, and history suggestive of post inflammatory depigmentation of lips secondary to various causes were excluded from this study. Also, patient vitiligo patients without lip involvement were excluded. The frequency, site, extension, association with vitiligo elsewhere, and systemic association were noted and tabulated. Results: Among 100 patients, 57 were males and 43 were females. Majority of our study subjects (63%) had onset of vitiligo between 11 and 30 years and 24% between 31 and 50 years. In the present study, 41 patients had only lip vitiligo, 55 patients had lip and vitiligo in other parts, four had involvement of lip and genital mucosa. Out of 100 patients, 71 complained that the lips were the initial lesion. The most type of vitiligo seen in our study subjects was the isolated lip vitiligo (41) and the least common was universal vitiligo (2). Leukotrichia was seen in three patients. In our study six patients had exclusive upper lip vitiligo and 40 patients had lower lip vitiligo. The remaining patients had both lower lip and upper lip involvement. Angle of the mouth was involved in 31 patients and five had marginal extension onto the skin. Of 100 patients with vitiligo nearly 19% had atleast one co-morbid condition. The most common autoimmune disease was thyroid dysfunction seen in 17% of patients. Conclusion: Though rare, lip vitiligo could be one of the earliest presentations of vitiligo and will aid in counseling the patients regarding the chronicity and thereby reduce the psychological morbidity. The data on lip vitiligo is sparse and to the best of our knowledge, there is no study on the demographic characteristics and clinical patterns of lip vitiligo.
Lichen planus pigmentosus masquerading as seborrheic melanosis
Authors: Dave Jayati Shailesh , Dongre Atul , Mahajan Sunanda Arun
Published: April 2024

Lichen planus pigmentosus is a macular variant of lichen planus commonly affecting photo-exposed areas. A 45-year-old female presented with asymptomatic blackish pigmentation on the both naso-labial folds, alar grooves, angle of mouth, lower lip, medial canthus, and eyelids since 8 years. Dermoscopy of these pigmented lesions revealed non-uniform accentuation of pseudoreticular pattern with dark brown dots and globules in arcuate and incomplete reticular fashion suggestive of lichen planus pigmentosus. Biopsy from the lesion showed perivascular infiltrate with heavily pigmented melanophages in the upper dermis. Based on clinico-pathological correlation and dermoscopic features, diagnosis of lichen planus pigmentosus was made.
Exploring the association between dermatoglyphic patterns and malocclusion types – A case–control study
Authors: Bhargava Ananya , Bhargava Apoorva , Saluja Imit Pal
Published: April 2024

Background and Objectives:

Dermatoglyphics is the study of fingerprints and skin patterns. During the intrauterine period, the development of dermatoglyphic patterns and dental hard tissues occurs at the same time. Dermatoglyphics has proved to be a potential tool in predicting dental anomalies. Hence, with the help of dermatoglyphics, we can explore the association between various dermatoglyphic patterns and types of malocclusion.

Methods:

A case–control study consisting of 150 children aged 12–14 years was selected. Based on the type of occlusion, the participants were grouped into skeletal class I normal occlusion (controls), skeletal class II malocclusion, and skeletal class III malocclusion. The fingerprints were analyzed using the ink method. The molar relation was determined according to Angle’s classification of malocclusion. The relation of fingerprints was studied with the molar relation recorded using the study models. Dermatoglyphic parameters were examined in these subjects.

Results:

In the study, it was observed that there was a notable increase in the occurrence of whorl pattern among patients with skeletal class II malocclusion (55%) and skeletal class III malocclusion (55.8%). On the other hand, in the skeletal class I group (controls), the frequency of loop pattern (66.6%) was found to be significantly higher. It was also noted that there was a slight decrease in the frequency of whorl patterns in skeletal class II patients as compared to skeletal class III patients.

Conclusion:

The whorl fingerprint pattern found in the study may indicate a higher likelihood of skeletal class II and III malocclusion in the general population.
Dynamic Simulation and Tradeoffs and Synergies of Ecosystem Service Value in Metropolitan Suburbs Using the PLUS Model
Authors: Zhang Chaoyu , Jia Qi , Liu Yijie , Li Ke , Gao Yanhong , Zheng Zhuyu
Published: April 2024

INTRODUCTION: Due to rapid economic development and continuous human activities, land use changes in the suburbs of metropolitan areas are drastic, which in turn affects the balance of ecosystem functions. Analyzing and predicting the ecological service value characteristics and trade-offs in rapidly urbanizing regions is of great significance for promoting high-quality regional development.AIM: This study attempts to reveal the trade-off and synergistic characteristics between the internal values of ecosystem services in suburban metropolitan areas under the influence of rapid urbanization.METHODS: Based on the patch-generating land use simulation (PLUS) model, simulated the land use changes in Xinzheng City under multiple scenarios in 2030, combined with methods such as equivalent factor method and spatial autocorrelation analysis，estimating, and predicting the ecosystem service value and its trade-off synergy relationship in Xinzheng City from 1980 to 2030.RESULTS: The value of ecosystem services in Xinzheng City continues to decline, hydrological regulation and soil conservation are the most important ecosystem service functions, under the scenario of farmland protection, ESV shows a stable growth trend. The synergistic relationship between various functions of ESV is significant, the Shizu Mountain National Forest Park, Shuangji River and other high agglomeration areas, as well as the Airport Economic Zone and Nanlonghu Town and other low agglomeration areas, all show a synergistic relationship, with only a portion of the southern side of the main urban area of Xinzheng showing a balancing relationship.CONCLUSIONS: Our findings can scientifically identify the environmental advantages of ecological sustainable development in Xinzheng City, and transform them into development advantages, providing provide strong technical support for the spatial ecological restoration and ecological security pattern construction of metropolitan suburbs.
Fault diagnosis of gearboxin wind turbine based on EMD-DCGAN
Authors: Meng Guangyi , An Yuxing , Zhang Dong , Li Xudong
Published: April 2024

INTRODUCTION: Wind turbine gearbox fault diagnosis is of great significance for the safe and stable operation of wind turbines. The accuracy of wind turbine gearbox fault diagnosis can be effectively improved by using complete wind turbine gearbox fault data and efficient fault diagnosis algorithms.A wind turbine gearbox fault diagnosis method based on EMD-DCGAN method is proposed in this paper.
OBJECTIVES: It can solve the problem when the sensor fails or the data transmission fails, it will lead to errors in the wind turbine gearbox fault data, which in turn will lead to a decrease in the wind turbine gearbox fault diagnosis accuracy.
METHODS: Firstly, the outliers in the sample data need to be detected and removed. In this paper, the EMD method is used to eliminate outliers in the wind turbine gearbox fault data samples with the aim of enhancing the true continuity of the samples; secondly, in order to make up for the lack of missing samples, a data enhancement algorithm based on a GAN network is proposed in the paper, which is able to effectively perfect the missing items of the sample data; lastly, in order to improve the accuracy of wind turbine gearbox faults, a DCGAN neural network-based fault diagnosis method is proposed, which effectively combines the data dimensionality reduction feature of deep learning method and the data enhancement feature of generative adversarial network, and can improve the accuracy and speed of fault diagnosis.
RESULTS and CONCLUSIONS: The experimental results show that the proposed method can effectively identify wind turbine gearbox fault conditions, and verify the effectiveness of the algorithm under different sample data conditions.
Need for standardization and compliance to treatment protocols for COVID-19 within the African Region of the World Health Organization
Authors: Fuller W. L. , Mukankubito I. , Nikiema J. B. , Ali Ahmed Y. , Aboderin A. O.
Published: April 2024

COVID-19 pandemic changed the face of global health and brought about new issues in global health security and economy. The World Health Organization published guidelines for clinical management of COVID-19 four months after declaration of COVID-19 as a pandemic. Scholarly reviews and studies from member states within WHO AFRO reveals significant deviation from the WHO published protocols on COVID-19. Assessment of national treatment protocols of 30 of 47 WHO AFRO member states showed widespread inappropriate use of antimicrobial agents for patients, which may worsen the global and concerning threat of antimicrobial resistance. There is need for adopting interventions that optimize antimicrobial use in the context of pre- and post-pandemic preparedness to ensure long-term effectiveness and sustainability for antimicrobials. Treatment guidelines are to be adopted or adapted depending on best clinical evidence available. Non-compliance with guidelines might lead to mismanagement of infectious diseases with attendant negative consequences including antimicrobial resistance and misdirection of critical resources and supplies amongst others.
Old Money: A poem
Authors: Haresnape Geoffrey
Published: April 2024

No Abstract
IMPLEMENTASI MODEL SEM PADA HUBUNGAN IPM, IPD DAN IDM
Authors: Sihombing Pardomuan Robinson , Arsani Ade Marsinta , Angraini Widdia , Pratiko Wisnu
Published: April 2024

This study aims to determine the influence of the Human Development Index (HDI), poverty and village funds on Village Development approached with the Village Development Index (IPD) and the Building Village Index (IDM). The data used is published data from the Ministry of Villages PDTT and the Central Statistics Agency in 2018. The analysis model used is the Structural Equation Model (SEM) model. The results of the village fund hypothesis test have not had a direct effect on IPD and have not had an indirect effect on IDM. The poverty rate has a significant negative effect directly on IPD and indirectly affects IDM, as well as HDI has a significant positive effect on IPD and indirectly affects IDM. IPD has a significant positive effect directly on IDM. A comprehensive and targeted policy is needed so that village development can take place in a sustainable manner. In addition, supervision is needed related to the use of village funds so that they are right on target in developing villages
UPAYA MENINGKATKAN KEMAMPUAN SELF CONTROL PADA ANAK MELALUI BERCERITA
Authors: Nur Maulida , Farida Neni
Published: April 2024

The purpose of this study is to increase the ability of self-control in children in group A at Al Mustaqim Kindergarten because there are still children in group A that are still lacking. Self-control is one of the emotional developments that need to be built since children are still small. Self-control is a person's ability to control himself so that his behavior is not detrimental to himself or to others. Self-control is also defined as the human capacity to control the response. Children must be taught self-control from an early age so that they are able to make their own choices in acting and take responsibility for their actions. This study uses a qualitative approach with classroom action research (CAR) methods and uses the Spiral model from Kemmis and Taggart. Based on observations in various aspects of the use of the storytelling method, it has been shown that the ability of self-control in cycle 1, cycle 2 and cycle to have shown a significant increase
UPAYA MENINGKATAN KEPERCAYAAN DIRI ANAK USIA MELALUI KEGIATAN MENJURNAL DI TKIT NUSANTARA BANTEN
Authors: Maemunah Siti Erma , Oktania Sella
Published: April 2024

The purpose of this study was to find out the process of implementing journaling activities to increase the self-confidence of group B children at TKIT Nusantara Banten. This study uses the Kemmis and Mc Taggart model of action research. The subjects in this study were the children of Group B TKIT Nusantara Banten. This research was conducted in two cycles, the first cycle consisted of eight meetings and the second cycle consisted of four meetings. Data analysis in this study used qualitative and quantitative. Quantitative analysis uses descriptive statistics to compare the results in the first cycle and the second cycle. Qualitative data analysis by analyzing data from field notes and interviews during the study with data reduction, data display and data verification steps. The results of this study indicate that self-confidence through journaling activities increases well. This can be seen from the success of each research cycle, where the results obtained in the pre-cycle were 46.30%, cycle I was 62.85% and in cycle II the confidence reached 82.52%. From the results found, the implication of this research is that journaling activities can be used as an alternative approach to increase children's self-confidence
PENGGUNAAN ECO-BRICK SEBAGAI MEDIA PEMBELAJARAN ANAK PRASEKOLAH DI PAUD KENDEDES
Authors: Kusuma Andini , Herawati Susi , Sarwiti Sarwiti , Kholifah Siti
Published: April 2024

The aim of this activity is to increase the knowledge and skills of Kendedes PAUD Serang City teachers in using ecobricks as a learning resource, especially as a starting material for making educational toys (APE). Ecobricks are ecological materials that do not decompose, obtained from used plastic bottles. This activity was motivated by the many waste problems, namely: (1) There is still a large amount of plastic waste in the environment that has not been utilized optimally, (2) Lack of knowledge regarding handling and disposal of plastic waste. . free environmentally friendly materials. teaching tools, (3) The nature of love for the environment in children will not develop without stimulation from the teacher. Based on this background, activities focus on teacher training to utilize eco-boards as a learning environment using environmentally friendly APE. The training method is carried out through lectures, questions and answers, demonstrations and practice in preparing APE. The results obtained indicate a growth in teachers' knowledge and skills in disposing of plastic waste using eco-bricks as a tool. Teachers can share their experiences with children and their parents
AKTUALISASI NILAI-NILAI PANCASILA PADA ERA REVOLUSI INDUSTRI 4.0
Authors: Utomo Vieto Budi , Widodo Slamet
Published: April 2024

Pancasila is the state ideology and an important reference for all Indonesian people. The noble virtues of Pancasila values ​​in the industrial era 4.0 were eroded by advances in science, technology, and art that were not filtered properly. Indications of the waning of Pancasila values ​​in the industrial era 4.0 can be seen from the increasing number of cases involving the nation's generation, which reflect the weakness of the nation's character, such as increasing crime, corruption, collusion and nepotism, radicalism, sexual crimes, consumptive life, political life that is not productive, etc. Efforts are needed to actualize Pancasila in the life of society, nation and state. By socializing the actualization of Pancasila values ​​in the industrial era 4.0, so that the credibility of Pancasila can be maintained in increasing awareness and responsibility of the nation's generation for a quality, intelligent, and characterized future. This research was conducted by using the method of literature review or literature review.
PENINGKATAN HASIL BELAJAR SISWA TENTANG KONSEP PECAHAN MELALUI PENERAPAN PENDEKATAN REALISTIC MATHEMATIC EDUCATION (RME) DALAM PEMBELAJARAN MATEMATIKA
Authors: Ikrom Fadhli Dzil , Sehabudin Sehabudin
Published: April 2024

Fractions are one of the most fundamental concepts in learning mathematics, so that fractions become a very important material in learning mathematics at the elementary school level. However, some students at Seroja Elementary School thought that fraction material was so difficult because they did not understand the concept of fractions well. This can be seen from the results of student learning which shows that the average grade obtained is still low. The method used is classroom action research conducted in three cycles. The research model applied is the model developed by Kemmis and MC Taggart which is generally carried out in four stages, namely (1) planning, (2) implementation, (3) observation, and (4) reflection. The research subjects in an effort to improve student learning outcomes through the application of the RME approach in learning were fourth grade students of Seroja State Elementary School, Serang City, Banten. The results of this study in classroom action research prove that the teacher's ability to apply the RME approach to learning mathematics about the concept of fractions increases and student learning outcomes increase. It can be concluded that there has been an increase in the teacher's ability to apply the RME approach to the concept of fractions in learning elementary mathematics. Furthermore, student learning outcomes regarding the concept of fractions have increased through the application of the RME approach in learning mathematics at SDN Seroja
PENERAPAN MODEL PEMBELAJARAN TEAM ASSISTED INDIVIDUALIZATION (TAI) UNTUK MENINGKATKAN HASIL BELAJAR IPAS PADA PESERTA DIDIK KELAS IV SD N CIWAKTU
Authors: Yulianto Fazri , Hendracipta Nana , Fajrudin Lili , Lucyana Lucyana
Published: April 2024

In efforts to improve student learning outcomes, the teacher must improve the learning process carried out. One of the efforts that teachers can make in improving the learning process to be able to improve student learning outcomes is by applying the Team Assisted Individualization (TAI) learning model. The Team Assisted Individualization (TAI) learning model is an effort to improve the learning process because this learning model emphasizes guidance between group members to understand and solve the problems being studied. This research is a Classroom Action Research (CAR) which aims to improve the learning process so that it can improve student learning outcomes. This Classroom Action Research was conducted in class IV of SD N Ciwaktu in science learning. The results showed that the learning completeness in the pre-cycle was 42.85% of the total number of students. In cycle I the learning outcomes of students increased by 17.86% and the level of completeness of student learning outcomes in cycle I reached 60.71%. Whereas in cycle II the percentage of completeness of student learning outcomes obtained reached 89.28% with the frequency of students completing in cycle II as many as 25 students. Based on the results of the study, it was concluded that the application of the Team Assisted Individualization (TAI) model could improve the learning outcomes of fourth-grade students at SD N Ciwaktu in the Science subject.