bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Safety of Immune Checkpoint Inhibitors and Chemotherapy in Advanced Non-Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis
Authors: Chen Ching-Yi , Huang Chi-Hsien , Chen Wang-Chun , Huang Ming-Shyan , Wei Yu-Feng
Published: December 2021

Backgrounds: Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy (CT) are the standard of care for first-line therapy in metastatic non-small cell lung cancer (NSCLC) patients without actionable mutations. The safety ranking of different ICI and CT combination regimens has not been investigated. This study was aimed to provide a toxicity profile and safety ranking of different ICI and CT combination regimens.Methods: We performed comprehensive searches of phase 2 and 3 randomized clinical trials (RCTs) comparing different ICI regimens (alone or combination) or CT for the first-line treatment of advanced NSCLC. Outcomes of interest were the cumulative incidence of any treatment-related adverse events (TRAEs), grade 3-5 TRAEs (grade 3-5), any immune-related adverse events (irAEs), and grade 3-5 irAEs (grade 3-5). Odds ratios and 95% credible intervals were calculated as summary statistics to quantify the effect of different ICI combination regimens. Results: We included 23 RCTs from 2016 to 2021 with a total of 14,378 patients. The incidence of any TRAEs and grade 3-5 TRAEs ranked from high to low were ICI-CT (probability: 74.88%), ICI-ICI-CT (50.60%), CT alone (74.79%), ICI-ICI (98.37%), and ICI monotherapy (99.37%). Adding CT to ICI regimens resulted in a higher incidence of any grade or grade 3-5 TRAEs compared to ICI-ICI combinations or ICI monotherapy. However, ICI-ICI-CT combinations did not result in a higher incidence of TRAEs than ICI-CT combinations. For any irAEs and grade 3-5 irAEs, the ranking was ICI-ICI (probability: 97.38), ICI monotherapy (96.98%), ICI-CT (99.44%), and CT alone (99.98%). Notably, the incidence of any grade and grade 3-5 irAEs was lower when adding CT to ICI monotherapy. Conclusion: Lack of head-to-head comparisons, these findings provide evidence for clinical decision-making when considering different ICI combination regimens for advanced NSCLC patients.
Triticum Aestivum L. cv. Guizi 1 ANS-6D Positively Regulates Leaf Senescence Through the Abscisic Acid Mediated Chlorophyll Degradation in Tobacco
Authors: Li Luhua , An Chang , Wang Zhongni , Xiong Fumin , Wang Yingxi , Ren Mingjian , Xu Ruhong
Published: December 2021

Anthocyanidin synthase (ANS) is involved in the synthesis of anthocyanins, which are important phytonutrients because of their beneficial effects on human health. Here, we identified ANS-6D of purple-colored Triticum aestivum L. cv. Guizi 1 (Gz) that is involved in leaf senescence through the abscisic acid (ABA) mediated chlorophyll degradation pathway in tobacco. After characterizing the leaf-senescence phenotype in GzANS-6D overexpression (OxGzANS-6D) lines, we found that the increased anthocyanin accumulation and decreased chlorophyll content in OxGzANS-6D lines were closely correlated with the expression levels of anthocyanin synthesis-related structural genes and senescence marker genes, as well as the accumulation of reactive oxygen species. The endogenous ABA content increased and ethylene content decreased in OxGzANS-6D transgenic lines compared with wild type. Additionally, the levels of the abscisic acid-responsive transcription factors ABF1 and ABF2, as well as those of chlorophyll degradation-related genes (PAO, NYC, SGR and CHL), were significantly higher in OxGzANS-6D transgenic lines than in wild type. Furthermore, we found that GzABF1 and NtABF1 binds to the promoter of GzANS-6D, and NtABF2 binds to the promoter of NtSGR. Thus, GzANS-6D participated in leaf senescence through ABA-mediated chlorophyll degradation, and ABF1/2 play important role in GzANS-6D functions.
Innovations in Emergency Airway Management: Lessons-Learned from Early Cross-Cultural Management of Covid-19
Authors: Sobel Annette L. , Duncan Robert V. , Lin Cuikun , Baca Robert , Carty Christopher , Dardik Trevor
Published: December 2021

The Texas Tech University Center for Emerging Energy Sciences Research Group implemented rapid translation and analytics of Chinese COVID-19 medical literature in February 2020, which enabled emerging innovations in patient care. Specifically, techniques to optimize patient care through
improved ventilation and oxygenation recognizing newly discovered pathophysiology were designed and prototyped in this invention. COVID-19 respiratory distress distinguishes itself from acute respiratory distress syndrome (ARDS) and pathophysiology of SARS-COV-2 by requiring higher O2 and
lower pressure requirements for adequate oxygenation. Specifically, low positive end-expiratory pressure ventilator parameters are necessary to optimize patient care. Paradoxically, COVID-19 patients display severe "silent" hypoxemia often associated with near normal respiratory compliance.
This clinical presentation is considered unusual for severe ARDS patients and implies non-uniformity in disease management of acute respiratory and pre-hospital patients. A clinical need for new innovative approaches to management that may also benefit decompression sickness, high altitude
pulmonary edema and other chronic respiratory disease patients.
 We present these observations as an example of the need for closely-collaborating, interdisciplinary teams to facilitate rapid innovation when sudden, severe health threats first emerge. This approach is invaluable
to medical innovations needed to counter threats due natural to man-made conditions.
COVID-19 implications for corporate social responsibility, corporate governance and profitability in banks: The case of Egypt
Authors: Abdelmoneim Zakia , Elghazaly Mahmoud
Published: December 2021

This paper aims to measure the relationship between Corporate Social Responsibility (CSR), Corporate Governance (CG), and profitability in listed Egyptian banks. COVID-19 is expected to affect this relationship if the year 2020 is taken. Profitability is measured by earnings per share (EPS), return on equity (ROE), and return on assets (ROA). CSR is measured as a dummy variable and CG is measured by the chief executive officer (CEO) duality. There are three control variables, such as the Islamic variable, which classifies a bank into Islamic or conventional, bank age, and bank size. The paper uses multiple regression and logistic regression models. The final sample is 12 banks consisting of 9 conventional banks and 3 Islamic banks (IBS). The results show no impact of profitability on CSR. The results prove a significant positive impact of profitability on CG; there is a significant negative relationship between CEO duality and EPS at a 0.05 level. CSR has a significant impact on CG at a 0.001 level. The results show a clear impact of COVID-19 on the impact of CSR on profitability only when measured by ROA at 0.001 in the period 2014–2019.
Natural Stilbene Polyphenols as Yarrowia lipolytica Cell Cytoprotectors at Heat Stress
Authors: Gessler N.N. , Isakova E.P. , Deryabina Yu.I.
Published: December 2021

Using the extremophilic yeast of Yarrowia lipolytica, a new model has been proposed to study the protective properties of stilbene polyphenols, namely resveratrol and pinosylvin, under heat shock. It was shown that a short-term thermal exposure of yeast cells (55 C, 25 min) led to a 40% decrease in the colony-forming ability of the population, a fivefold decrease in the respiration rate, and a growth of cyanide resistance and catalase activity, which indicated the adaptive yeast response to heat stress. Under these conditions, natural biologically active stilbenes, resveratrol and pinosylvin, at a concentration of 10 μM each increased yeast survival by 28% and 13%, respectively. In heat shock, resveratrol additionally raised catalase activity, while pinosylvin increased the cell respiration rate and decreased cyanide resistance and catalase activity. The results obtained indicate that resveratrol acts as a mild pro-oxidant inducing antioxidant protection during the adaptive response of the yeast to heat shock. Unlike resveratrol, pinosylvin increases cell survival stabilizing mitochondrial function and preserving the ATP-generating component of respiration.

Yarrowia lipolytica yeast, polyphenols, stilbenoids, resveratrol, pinosylvin, cellular respiratory activity, heat shock, superoxide dismutase, catalase
Cloning, Isolation, and Properties of a New Recombinant Tannase from the Aspergillus niger Fungus
Authors: Matys V.Yu. , Nemashkalov V.A. , Rozhkova A.M. , Shashkov I.A. , Satrutdinov A.D. , Kondratyeva E.G. , Sinitsyn A.P.
Published: December 2021

A new recombinant Aspergillus niger tannase (tannin acyl hydrolase) produced by the Penicillium verruculosum fungus has been studied. A strain with a high level of extracellular tannase (TAN2) secretion (80% of the total extracellular protein) was obtained by cloning the tan2 gene (PDB Acc. No: MT828303) into the recipient strain. The tannase enzyme preparation degraded tannins in black tea extracts. TAN2 was isolated in homogeneous form using chromatographic methods; the enzyme had a high activity against gallotannin (53 U/mg) and less activity against propyl gallate (4.7 U/mg). Homogeneous TAN2 showed temperature and pH optima of 45 °C and 3.5, respectively. At a temperature of 50 °C, TAN2 retained above 80% activity for 3 h; at 60 °C, it retained about 75% of its activity for 90 min; at 70 °C, the enzyme was completely inactivated within 10 min. Tannase was characterized by a high tolerance to NaCl, the activity against gallotannin exceeded 50% of the initial value in solutions with a salt concentration of up to 5 M. The tannase activity was stimulated by Ca2+, Mg2+, Zn2+, Mn2+, Cu2+, Cd2+, Pb2+ by 3--64% and inhibited by 4-65% in the presence of Co2+, Fe3+ and Fe2+ ions.

tannase, tannins, Aspergillus niger, Penicillium verruculosum

This work was supported by the Ministry of Science and Higher Education of the Russian Federation.
Construction and Functional Analysis of Mycolicibacterium smegmatis Recombinant Strains Carrying the Genes of Bacillary Cytochromes CYP106A1 and CYP106A2
Authors: Nikolaeva V.M. , Fokina V.V. , Shutov A.A. , Kazantsev A.V. , Strizhov N.I. , Donova M.V.
Published: December 2021

Mycolicibacterium smegmatis mc2155 has been genetically modified to be used as a platform for the expression of foreign cytochrome P450 monooxygenases by introducing deletions in the kshB and kstD genes that encode key stages of the enzymatic destruction of the steroid nucleus. Three sets of genetic constructs have been created for heterologous expression of the genes of cytochromes P450 CYP106A1 from Bacillus megaterium DSM319 and CYP106A2 from Bacillus megaterium ATCC13368 in Mycolicibacterium smegmatis mc2155 (ΔkshBΔkstD) cells. The recombinant plasmids contained monocistronic expression cassettes of cytochrome genes (NS31 and pNS32), or tricistronic cassettes of cytochrome genes together with cDNA copies of adrenodoxin and andrenodoxin reductase genes of the bovine adrenal cortex (pNS33 and pNS34), or monocistronic gene cassettes of chimeric cytochromes fused with the DNA sequence encoding the CYP116B2 reductase domain from the soil bacterium Rhodococcus sp. NCIMB 9784 (pNS35 and pNS36). The recombinant strains of mycolicibacteria were shown to selectively monohydroxylate androstenedione (AD) under growth conditions. The product was identified as 15-hydroxyandrostenedione (15-OH-AD) by mass spectrometry and 1H and 13C NMR spectroscopy. The maximum level of 15-OH-AD production (17.3 ± 1.5 mg/L) was observed when using the recombinant M. smegmatis mc2155 (ΔkshBΔkstD) (pNS32) strain, which expresses a single cyp106A2 gene from B. megaterium ATCC13368. Host proteins of M. smegmatis mc2155 were shown to be capable of supplying electrons to heterologous cytochromes to support their hydroxylating activity. The results are of priority character, expand the understanding of the hydroxylation of steroid compounds by bacterial cytochromes CYP106A1/A2 and are important for the creation of microbial strains producing valuable hydroxysteroids.

cyp106A1, cyp106A2, cytochrome P450, heterologous expression, Bacillus megaterium, Mycolicibacterium smegmatis, 15β-hydroxylation, bioconversion, steroids

This work was supported by the Russian Science Foundation (project No. 21-64-00024).
Genetic Diagnostics of FANC1BY Mutation in Representatives of the Holstein Breed and Its Crosses
Authors: Devrishov D.A. , Turbina I.S. , Alekseev Ya.I. , Konovalova N.V. , Marzanov N.S.
Published: December 2021

The article is devoted to the development and use of a method for diagnosing the source of Brachyspina Syndrome, or short spine, in the Holstein breed and its crossbreeds. Representatives of this breed are the most highly productive animals in the world for milk. The development of a diagnostic method for breed-specific hereditary carriers is an important task in dairy farming. In this regard, the authors have proposed a Patent and a Reagent Kit for the detection of normal FANC1TY and mutant FANC1BY alleles in the Holstein breed and its crossbreeds. The frequency of occurrence of genotypes formed by these alleles in different sex and age groups of animals in the Holstein breed and its high-blooded hybrids was studied. Historical data related to the founders, from whom the spread of the mutant FANC1BY allele within the Holstein breed itself and its crossis in the USA, Canada and Russia began, has presented. The development of a diagnostic method for the mutant FANC1BY allele will make it possible to stop spreading of the Brachyspina Syndrome source. The proposed method will make it possible, in the early stages, to form healthy groups of breeding animals (bulls, replacement bulls, bull-reproducing cows), thereby laying the foundation for creating a high-quality livestock in the regions where the Holstein breed and its numerous crossbreeds are bred.

cattle, Holstein breed, crossis, genotype, FANC1BY mutation, allele, Brachyspina syndrome
Monsoon Variability Reconstructed from Sedimentological and Mineral Magnetic Studies from Vaghad Tank Deposits, Nashik District, Maharashtra
Authors: Magar Arun
Published: December 2021

An attempt made to reconstruct the monsoon variability using sedimentological, geochemical and mineral magnetic studies from deposits in Vaghad Tank, Nashik district, Maharashtra (India). The ~140 years multi-proxy data of the 3.3 meter thick sedimentary section of the tank exhibits some minor changes in sediment characteristics up to the depth of ~150 cm. The grain-size analysis and mineral magnetic studies of 67 samples of sediment suggests that, the sediment dominated by clay. Overall, sedimentary profile does not exhibit any systematic trend in the sediment properties. Finally, the present study concludes no significant changes in the past monsoon conditions have been occurred during the last century but some minor changes in the hydrodynamic conditions have been noticed during the last few decades.
O FETICHE DOS DIREITOS HUMANOS NO CAPITALISMO: A SEPARAÇÃO ENTRE A ÉTICA E A POLÍTICA NA MODERNIDADE
Authors: Marques da Silva João Victor
Published: December 2021

Os Direitos Humanos ainda se apresentam como uma ferramenta de desenvolvimento humano sob a égide da sociedade burguesa, em que pese a conjuntura atual de intensas e profundas transformações socioeconômicas erigidas em nome da reprodução social do capital. Diante de tal contexto, os Direitos Humanos perdem força argumentativa e fundamentação prática, o que sinaliza para a necessidade de sua compreensão, a partir da teoria marxiana do valor e do fetichismo, problematizando o seu conceito de ser humano, no âmbito da emancipação do sujeito ético-moral. Para tanto, utiliza-se como método o materialismo dialético e a pesquisa qualitativa como perspectiva de abordagem. Por fim, argumenta-se que o ideário dos Direitos Humanos no âmbito da sociedade capitalista se apresenta como um discurso fetichizado.
Small and medium enterprises in public procurement: Factors affecting the decisions of public bodies
Authors:   National Research University Higher School of Economics, Kashin Dmitriy V.
Published: December 2021

The study assesses factors influencing public bodies’decisions to conduct purchases with small and medium enterprises (SMEs). Mechanisms supporting SMEs are enshrined in the laws governing the system of state and state-corporate procurement in Russia and are mandatory for Russian contracting authorities. The inclusion of these mechanisms in the public procurement legislation implies their direct (explicit) impact, which applies equally to all regulated organizations. However, despite some similarities in the mechanisms for supporting SMEs in the laws on public procurement (both laws dictate to conduct set-aside procedures for SMEs), the frequency of procurement with SMEs participation differs between 44 FL and 223 FL. The study revealed that the choice of contracting authorities is influenced by the type of law, the position in the public power hierarchy, and the form of ownership of the organisation. The decision to purchase from SMEs is also related to the subject of the procurement and the method of identifying a supplier. The results of the study demonstrate heterogeneity in the behaviour of contracting authorities when purchasing from SMEs and explain the reasons of heterogeneity by differences in the regulatory pressure.
Rheumatoid arthritis associated with Rendu — Osler — Weber disease: Second description
Authors:   St. Petersburg State University, Churilov Leonid ,   St. Petersburg Research Institute of Phthisiopulmonology, de Carvalho Jozélio Freire ,   Institute for Health Sciences, Federal University of Bahia, Maia Rodrigues Carlos Ewerton ,   Universidade de Fortaleza, de Freitas Zerbini Cristiano Augusto ,   Centro Paulista de Investigação Clinica
Published: December 2021

The article presents second ever published description of rheumatoid arthritis case co-morbid with Rendu — Osler — Weber disease (hereditary hemorrhagic teleangiectasia) in a 63-yearsold female patient. The aim is describing the first case report of a patient who after a confirmed hereditary hemorrhagic teleangiectasia diagnosis developed rheumatoid arthritis one year later. Historical data and brief pathophysiological characteristic of both diseases and their possible intermingle are included: (i) mutant genes in hereditary hemorrhagic teleangiectasia all encode proteins involved in the TGF-beta signaling pathway, and increased plasma levels of TGF-beta-1 and vascular endothelial growth factor have been seen in such patients; (ii) TGF-beta plays a role in the development of synovial cell proliferation, inflammation, and angiogenesis in rheumatoid arthritis; (iii) TGF-β regulates thymic T-cell selection, inhibits cytotoxic T lymphocyte (CTL), Th1-, and Th2-cell differentiation while promoting peripheral * Contribution of L. P. Churilov was supported by the grant of the Government of Russian Federation for state support of scientific research carried out under the supervision of leading scientists, agreement 14.W03.31.0009.Treg-, Th17-, Th9-, and Tfh-cell generation, and T-cell tissue residence in response to immune challenges, all essential for pathogenesis of rheumatoid arthriitis. The defect in its reception as well as its compensatory increased blood content theoretically can alter autoimmunity thus facilitating in Rendu — Osler — Weber disease patients the development of systemic autoimmune diseases.
Prediction of the fact and degree of coronary artery disease using the processing of clinical and instrumental data by artificial intelligence
Authors:   Sogaz International Medical Center, Abdualimov Timur , Obrezan Andrey ,   Sogaz International Medical Center,   St. Petersburg State University
Published: December 2021

Aim of the study was to analyze the possibility of using neural network analysis to predict the severity of coronary bed lesion. The study was also designated to determine the performance and accuracy of the trained neural network model receiving input as the structured data and EGG images with the parameters and leads positioning differ from the training sample, and also to compare the efficiency of detecting transient myocardial ischemia with traditional diagnostic methods, such as 24-hour Holter monitoring, treadmill test. Neural network analysis of the available clinical, laboratory and instrumentation data allow to configure the network parameters for further prediction of coronary artery disease. The results obtained in the form of an AUC score allow to consider this method to be effective in the coronary artery disease diagnosis using recorded ECG tape with parameters and lead positioning differ from initial training sample. The efficiency of transient myocardial ischemia detection on the training sample of the trained neural network is higher in comparison with traditional diagnostic methods, such as 24-hour Holter monitoring, treadmill test.
Women’s organizations as a segment of civil society of modern Russia
Authors:   Far Eastern Federal University, Lomova Tatyana E.
Published: December 2021

The article analyses women’s organizations of modern Russia as a component of civil society. The study is based on the gender approach and materials analyzed include statistical data, results of opinion polls, websites of women’s organizations, interviews and other documents. The women’s movement is considered as one of the social practices in the context of the theory of practices proposed by Pierre Bourdie, Robert Connell and others. The author notes that the peak of women’s activity in Russia was in the 1990s, when women were uniting to solve social problems, such as women’s unemployment, human trafficking, etc. During that time, the women’s movement in Russia was developing with the support of international women’s organizations and foreign charity funds, but after the adoption of the so-called law on “foreign agents” many funds suspended or limited their activities in Russia. As a result, nowadays, many Russian NGOs including women’s organizations are facing financial problems. NGOs recognized as a “foreign agent” experience the most difficulties while organizations with the status of socially oriented NGOs can receive government’s support and funding. Using the method of content analysis, the author revealed that names of Russian women’s organizations often include such words as “family”, “childhood”, and “motherhood”, whereas the words “woman”/“women” and ‘women’s’ are rarely used. This is due to the fact that in Russian society there are still widespread views that the range of women’s interests should be limited to the private sphere. At the same time, the gender theory and feminism are often presented as attempts to undermine national traditions. As a result, a woman is considered as an object of social policy rather than a subject of social processes. The majority of Russian women’s organizations focus on charity work, but specific women’s interests and problems are often ignored or undervalued. However, domestic violence, labour market discrimination, and other gender problems can be solved only through the close interaction of the “third sector”, business, and government.
The genesis of Western European sociological thought in the works of G. V. Plekhanov
Authors:   St. Petersburg State University of Economics, Brazevich Svyatoslav S.
Published: December 2021

The article presents the results of the analysis by G.V.Plekhanov of the genesis of Western European sociological thought based on the consideration of the social ideas of the French materialists of the 18th century, the rudiments in their philosophical systems of the historical approach to the study of society and understanding the causes of social inequality and injustice as well as overcoming them. The sources and content of the philosophical and historical theories of the French historians of the Restoration period are revealed, those who recognized the struggle of classes as the cornerstone of the social, political and mental development of European society, including the interpretation of the concept of “social environment” as a set of economic relations of classes, which was a contribution to the history of sociology. The analysis of the sociological views of utopian socialists and representatives of German classical philosophy is conducted. It was revealed that a significant contribution to the development of the theory of society were the ideas of social progress and the creation of a new social science that served the cause of social organization, developed by the utopian socialists, as well as the statement that the future of society is decided in the sphere of social and economic relations, and not political and legal ones. It is emphasized that Hegel’s application of dialectics to the analysis of social changes meant undoubted progress in the development of sociological thought, which consisted in the advancement of the idea of the regularity of the social process. The methodological basis of the author’s study of the problem of the genesis of Western European sociological thought in the works of G.V.Plekhanov is made up of dialectical-materialistic and comparative-historical methods, as well as the method of textological analysis and historical-philosophical reconstruction.
Persistence of fecal indicator bacteria and associated genetic markers from wastewater treatment plant effluents in freshwater microcosms
Authors: Chern Eunice C. , Wymer Larry , Brenner Kristen , Oshima Kevin , Haugland Richard A.
Published: December 2021

Limited information exists on the environmental persistence of genetic markers for fecal indicator bacteria (FIB) in treated wastewaters. Here, the decay rate constants of culturable cells and genetic markers for four diverse groups of FIBs, such as enterococci, Clostridium, Escherichia coli, and Bacteroides, were investigated in freshwater microcosms seeded with disinfected and non-disinfected secondary-treated wastewaters. Decay rate constants of genetic markers and culturable cells varied significantly among the different FIB groups. Water temperatures (winter vs. fall/spring/summer) significantly affected the decay of all genetic marker and cell types; however, genetic marker decay were not found to be significantly different in disinfected (chlorination/ultraviolet) and non-disinfected wastewater-seeded microcosms or, for example, lake- and river-receiving waters. No evidence was seen that decay rate constants of FIB genetic markers from treated wastewater were substantially different from those observed in similar, previously reported microcosm studies using raw sewage. Unexpected relationships between decay rate constants of genetic markers and culturable cells of Bacteroides were observed. Results suggest that decay rate constants of FIB genetic markers determined from other studies may be applicable to treated wastewaters. Results of this study should be informative for ongoing efforts to determine the persistence of FIB genetic markers relative to surviving pathogens after wastewater treatment.
Rapid Serological Testing for Managing the COVID-19 Pandemic: A Review
Authors: Faheem Sultan M. , D’Mello Jancie , Kaleem Sultan M. , Prasad Burra V. L. S. , Siddiqui Khalid
Published: December 2021

With the onset of the novel coronavirus disease pandemic (COVID-19) that emerged from Wuhan in China, the need of the hour can be summarized into two groups. The first one is a potent vaccine as a prophylactic measure to prevent the virus from infecting people, and the second is a rapid diagnosis of the disease to help healthcare professionals and government authorities to plan and control the spread and provide effective care and treatment. This review delves into the latter, describing the COVID-19 and its treatment, including the race for an effective vaccine, and highlighting the role of serological testing in managing the pandemic since a well-designed study to understand mechanisms and serological correlations of protective immunity is crucial for rational clinical and public health policies. In conclusion, swift vaccination and response tactics, such as social distancing, hand hygiene, wearing of masks, and, if required, lockdown practices continue to be important in managing the pandemic while carefully monitoring any possible outbreak due to the variants.
DISFEMISME PADA KOLOM KOMENTAR AKUN INSTAGRAM @rahmawatikekeyiputricantikka23
Authors:   Universitas Sebelas Maret, Ayu Widya , Nur Aziza Anisa , Kusuma Amalia , Nurul Ika
Published: December 2021

Social media becomes a space to express feelings and opinions freely. However, freedom of speech is now abused by internet citizens to freely express words that mean rude, blasphemous, insulting, or in language science called disfemism. This research aims to describe the form and function of disfemism in the comment column of kekeyi public figure's Instagram @rahmawatikekeyiputricantikka23. The research method uses a descriptive qualitative method. The research data are words, phrases, and sentences containing disfemism in the comments column of the Instagram @rahmawatikekeyiputricantikka23 in July 2020. The data collection method uses the simak method with a recording technique—data collection techniques with documentation techniques. Data analysis uses the agih method with basic natural elements, substitution or substitution techniques, and removal techniques. Based on the results of this study found 279 data on disfemism. The found forms of disfemism are words, phrases, and phrases. The word disfemism form amounts to 90 data, the form of phrase disfemism amounts to 100 data, and the expression disfemism form amounts to 89 data. There are seven functions of disfemism found in this study, among them: (a) as an intermediary to express taboo or indecent things, (b) as a sign of dislike, hate, and disrespect, (c) as an intermediary to express anger or aggravation, (d) as a negative depiction of something, (e) as a means of insulting and mocking, (f) as a means of criticizing, and (g) as a means to exaggerate something and scold.
KRITIK ARAFAT NUR TERHADAP TATANAN SIMBOLIK DAN SUBJEK DALAM NOVEL BURUNG TERBANG DI KELAM MALAM
Authors:   Universitas Gadjah Mada, Tiara Merdika Fitri
Published: December 2021

In the creation of literary works, either consciously or unconsciously the author will always insert his ideology. The insertion of the ideology can be seen from the criticisms delivered by the author. Literary works are a medium for the author to convey a critique of the reality that occurs, be it religious, social, cultural, political and other criticisms. But that becomes interesting when the author tries to open up an unconscious reality, opening up the decay of a system of power that will eventually become cynicism and submit to an ideological order. In this study, Arafat Nur's novel Burung Terbang di Kelam Malam was chosen to prove this ideological fantasy. The problem contained in this study is (1) What is the symbolic order of acehnese people in the novel Burung Terbang di Kelam Malam? (2) What is Arafat Nur's criticism of the subject (Acehnese) in the novel Burung Terbang di Kelam Malam? To answer that question, the theory used was an authentic subject and ideological fantasy introduced by Slavoj Zizek and analyzed with descriptive analytical methodology. The results of this study prove that, firstly, the symbolic order (Islamic Sharia as the identity of Aceh) failed to form a radical subject. Although the subject has relinquished the symbolic order that shackled him all along, he remains returning to the new symbolic order. The subjects who are still in power of the Big Other will never escape from the order that subjected them. The subject will not be able to reach the Real, because they cannot discuss it so the subject desires to fulfill Che Vuoi's call?, unconsciously the subject commits ideological fantasies. Second, the subject of fantasizing the ideology of Islamism (Islamic sharia) that desires the achievement of spirituality instead leads it to capitalism. Not just the subject (the character in the novel). Arafat Nur as an author was also caught up in capitalism so his attempts to go radical ended in failure.
TRANSFORMASI NOVEL SERENDIPITY KE DALAM FILM SERENDIPITY KARYA ERISCA FEBRIANI: KAJIAN SASTRA BANDINGAN
Authors:   Universitas Singaperbangsa Karawang, Nurkamilai Novia , Dwi Aprilliah Yola , Hartat Dian
Published: December 2021

This comparative analysis descriptive study aims to (1) describe the transformation of the novel Serendipity into the film Serendipity, and (2) describe the social conflicts contained in the novel Serendipity by Erisca Febriani. The data sources for this research are the film and novel Serendipity by Erisca Febriani. The data of this research are in the form of sentences contained in the Serendipity Novel and Serendipity Film by Erisca Febriani with a sociological approach to literature. This research data collection by watching the film Serendipity and literature study. This study uses a sociology of literature approach with the following steps: (1) determining the subject and object of research, (2) research work (data reduction, data presentation, and drawing conclusions). The results of this study indicate that (1) the transformation of the novel into the film Serendipity shows several changes when it is adapted into a film, and (2) the social conflict in the novel Serendipity by Erisca Febriani is built by one conflict, namely socio-economic conflict.
THE IMPACT OF USING INFLUENCER ON CONSUMER PURCHASE INTENTION WITH ATTITUDE TOWARDS INFLUENCER AND BRAND ATTITUDE AS MEDIATOR
Authors:   International Business Management, Fakultas Manajemen dan Bisnis, Universitas Ciputra Surabaya, Immanue Dewi Mustikasari , S. Alexandria Bianda H. ,   International Business Management, Fakultas Manajemen dan Bisnis, Universitas Ciputra Surabaya
Published: December 2021

This study is conducted to determine the effect of perceived credibility, trust, experience, and attractiveness as an evaluator of influencers' effectiveness on consumer purchase intention in fashion products mediated by attitude towards influencers and brand attitude. Influencers are those who regularly share content related to certain fields or skills on social media platforms. This study is based on the Theory of Planned Behavior (TPB) and other previous studies related to influencers' effectiveness on purchase intention of fashion products. The population in this study is 385 women in Surabaya with a non-probability sampling method using a purposive sampling technique. The data analysis method used in this study is Structural Equation Modeling-Partial Least Square (SEM PLS) with a smart PLS 3.0 program. The analysis results in this study show that perceived credibility, trust, and attractiveness have a positive and significant effect on attitude towards influencers. In contrast, perceived expertise has a negative and insignificant impact on attitude towards influencers. Attitude towards influencers fully mediates the influence of perceived credibility, trust, and attractiveness on brand attitude and purchase intention. Brand attitude fully mediates the influence of attitude towards influencers on purchase intention. In this study, variable perceived expertise used did not affect attitude towards influencer variables. This is different from previous studies that have been done before. For further researchers, it is suggested that they can again use perceived expertise and other variables that can support more deep assessments that give rise to consumer attitudes towards an advertisement made by fashion product influencers in subsequent studies using different populations. The analysis model that has been used in this study can then be reused in conducting further research with varying numbers of populations and types.
ANALYSIS OF THE IMPACT OF WORKLOAD AND WORK STRESS ON JOB SATISFACTION WITH MOTIVATION AS INTERVENING VARIABLE
Authors:   Magister Management, Universitas Sarjanawiyata Tamansiswa Yogyakarta, Kirana Kusuma Chandra , Lukitaningsih Ambar ,   Magister Management, Universitas Sarjanawiyata Tamansiswa Yogyakarta, Londin Dorce Marchiliya ,   Magister Management, Universitas Sarjanawiyata Tamansiswa Yogyakarta
Published: December 2021

This study aims to analyze the impact of workload and work stress on job satisfaction with the motivation of a solution to the intervention of the nurse team covid-19 Maluku Southeast. Data collection was carried out through the distribution of questionnaires to 33 nurses. As for the method used in this study, there are modeling research methods using partial analysis tools at least square. The findings of this study are: The workload is not proven to have a negative and significant effect on motivation, work stress is not proven to have a negative but significant impact on motivation, the workload is not proven to have a negative and significant impact on job satisfaction, the work stress is proven to have a negative but insignificant effect on job satisfaction, the motivation proven to have a positive and significant impact on job satisfaction, Workloads have not proved to affect work satisfaction through motivation, work stress has proved to affect work satisfaction through motivation. The author suggests that research on job satisfaction can use variables other than workload, job stress, and motivation to reveal other contributions outside of these variables.
ANALYSIS OF THE EFFECT OF KNOWLEDGE MANAGEMENT, COMPETENCY, AND INNOVATION ON EMPLOYEE PERFORMANCE
Authors:   Master of Management Science, Faculty of Economics and Management, Institut Petanian Bogor, Wibowo Dwi Yoga Ari , Muljono Pudji ,   Faculty of Economics and Management, Institut Pertanian Bogor, Sumertajaya I Made ,   Faculty of Economics and Management, Institut Pertanian Bogor
Published: December 2021

The conformity of employee competencies with their positions and innovation in work implementation is required by the presence of the Civil Servants (PNS) professional demands. Knowledge management is necessary to fulfill the knowledge needs of employees so that competence, innovation, and employee performance can be improved. This study aims to analyze the effect of knowledge management, competence, and innovation on employee performance. All employees in the Finance and Equipment Bureau of the Ministry of Agriculture were involved as the research object. The data were obtained using the census method of 103 Finance and Equipment Bureau employees, interviews with appraisal officials and personnel managers, and employee performance appraisals in 2019. The data processing uses Structural Equation Modeling - Partial Least Square (SEM PLS) analysis. This study indicates that knowledge management has a significant effect on innovation and competence, whereas innovation significantly affects performance. However, knowledge management and competence do not seem to have a significant effect on employee performance. Knowledge management indirectly has a significant effect on performance through innovation. Nevertheless, knowledge management does not seem to have a significant effect on performance through competence. The suggestion for further research is it shall be conducted in a work unit that requires special skills so that the employee competence is taken into consideration.
FACTOR INFLUENCING THE LOYALTY OF DOMESTIC AND FOREIGN TOURISTS
Authors:   Department of Management, Institut Pertanian Bogor, Munandar Jono M.
Published: December 2021

The Tourist Information Center (TIC) Soekarno Hatta International Airport Jakarta is an institution with service activities with a core of tourism marketing and promotion through the delivery of tourist information to domestic and foreign tourists visiting the TIC booth. That research was conducted to determine the effect of the quality of the physical environment, the quality of interaction of front liner officers, the quality of service results, and the quality of e technology provided by TIC on the loyalty of domestic and foreign tourists as the dependent variable. This study uses quantitative methods using a questionnaire in data collection. Sampling using accidental sampling with research variables as many as 35. At the same time, the number of respondents involved consisted of 69 domestic tourists and 106 foreign tourists. Furthermore, the data analysis used Structural Equation Modeling (SEM) Smart PLS 2.0 program. The results of testing the first hypothesis on domestic tourists show the positive influence of interaction on tourist loyalty. The path coefficient value is greater than the t table and p-value. Testing the second hypothesis on foreign tourists shows the positive influence between the quality of the physical environment and the quality of interaction on tourist loyalty. The coefficient value of the environmental quality pathway is greater than the t table and the p-value.
EFFECT OF CUSTOMER RELATIONSHIP MANAGEMENT TO CUSTOMER RETENTION MEDIATED BY CUSTOMER SATISFACTION AND CUSTOMER LOYALTY
Authors:   PT. Bank Tabungan Negara (Persero), Tbk, Tifliyah Siti Zainut , Rohman Fatchur ,   Faculty of Economics and Busines, Brawijaya University, Noermijati Noermijati ,   Faculty of Economics and Busines, Brawijaya University
Published: December 2021

The purpose of this study was to analyze the effect of Customer Relationship Management (CRM) on customer retention mediated by customer satisfaction and customer loyalty on Priority BTN in Malang City. The population of this study is Priority BTN customers in Malang City, and the number of samples obtained is in accordance with the research criteria as many as 100 samples. The approach used in this study is a quantitative approach. The type of research based on the formulation of the problem and the purpose of the study is explanatory. The technique used in this study is probability sampling with a simple random sampling method. The research instrument used was a questionnaire analyzed using SmartPLS 3.0 software. The results showed that CRM has a direct influence on customer retention. In addition, CRM indirectly affects customer retention through mediating variable customer satisfaction and customer loyalty. The next researcher can conduct further research with broader research objects, namely at the BTN Priority bank customers nationally, and can use web-based surveys to shorten the time in researching priority customers because priority customers have high mobility.
DETERMINANT MODELS AFFECTING FINANCIAL PERFORMANCE AND STOCK RETURN COMPANIES REGISTERED IN INDONESIA STOCK EXCHANGE
Authors:   Sekolah Tinggi Ilmu Ekonomi Pelita Indonesia, Sudarno Sudarno , Suyono Suyono ,   Sekolah Tinggi Ilmu Ekonomi Pelita Indonesia, Yusrizal Yusrizal ,   Sekolah Tinggi Ilmu Ekonomi Pelita Indonesia, Tambunan Johannes ,   Sekolah Tinggi Ilmu Ekonomi Pelita Indonesia
Published: December 2021

This research aims to analyze the effect of Capital Adequacy Ratio (CAR), Operating Expenses to Operating Income Ratio (BOPO), Loan to Deposits Ratio (LDR), Net Interest Margin (NIM), and Non-Performing Loan Ratio (NPL) variables on ROA and Stock Return of Banks That Listed in the Indonesia Stock Exchange. The population in this research is all banks listed on the Indonesia Stock Exchange. At the same time, the samples are 30 companies. The sampling uses the purposive sampling method. Secondary data was obtained in the Indonesia Stock Exchange and Yahoo! Finance. The independent variables used are CAR, BOPO, LDR, NIM, and NPL. The data analysis technique used is multiple linear regression analysis by SmartPLS software. This research indicates that the LDR, NIM, and NPL variables have a significant effect on ROA. The CAR, BOPO, and NPL variables have a significant effect on Stock Return. The predictive ability of the independent variables (CAR, BOPO, LDR, NIM, and NPL) on ROA is 59.5%, as indicated by the value of Adjusted R Square is 59.5%, while the remaining is 40.5% influenced by other variables not included in this research. The independent variables (CAR, BOPO, NIM, and NPL) on Stock Returns have 13.3% of Adjusted R Square while the remaining is 86.7% influenced by other variables.
THE EFFECT OF FINANCIAL POLICY ON THE PERFORMANCE OF INDUSTRIAL COMPANIES IN THE INSURANCE SUB-SECTOR IN INDONESIA
Authors:   Universitas Brawijaya, Malang, Saif Muhammad
Published: December 2021

Companies with good profitability will have better abilities to fund their dividends and investments. Companies experiencing a lack of funding to fund dividend payments and fund investments can use external funding through leverage. The object of this study is the industrial company of the insurance sub-sector; the selection of this object is based on the idea that insurance as a financial product is supposed to give an assurance to its customers regarding the promised coverage. This study is purposed to examine and explain the effect of financial policy on the company and its performance. The analytical method used is Partial Least Square with purposive sampling technique. The sample used is insurance companies listed on the IDX during the 2017-2019 period. Variables used in this study regarding the effect of financial policies on a company's performance are investment opportunity set, dividend policy, capital structure, and firm value. Based on the analysis results, it is shown that the mediation of Capital Structure and Dividend Policy give a significant positive effect on a company's performance as reflected in the firm value obtained. Thus good financial policies can be used as a strategy to attract investors' interest. The results of this study are expected to benefit the company's leadership in optimizing the company's value through the established financial policies.