bluuebunny/crossref_metadata_2025 huggingface dataset:
FRAS1-related extracellular matrix protein 2 drives the progression and poor prognosis of IL-1β-associated esophageal squamous cell carcinoma
Authors: Wang Lin , Gu Jie , Liu Ronghua , Mao Wei , Xu Fengkai , Liu Zhonghe , Shou Huankai , Zhu Qiaoliang , Lu Chunlai , Chu Yiwei , Wang Qun , Lin Zongwu , Ge Di
Published: December 2019

Background Chronic inflammation generates a tumor-supporting microenvironment, but it remains unclear whether and how the persistent inflammation drives genetic abnormalities leading to the occurrence and progression of esophageal squamous cell carcinoma (ESCC). Methods By global RNA-sequncing, we screened genes related to ESCC with stimulation of the pro-inflammatory factor, interleukin (IL)-1β, and identified FRAS1-related extracellular matrix protein (FREM)2 as a oncogene. Flow cytometry was used to detect the expression of IL-1β and its receptor IL-1R1 in fresh ESCC specimens. The interaction between FREM2 and IL-1β signal was examined in vitro and in vivo. Levels of FREM2 and IL-1R1 were determined in ESCC tissue arrays derived from 299 patients, and their correlation with clinical outcomes was analyzed. Results Multiple genes-related to ESCC occurrence and recurrence were elevated when exposed to the persistent stimulation of IL-1β. Among them, FRAS1-related extracellular matrix protein 2 (FREM2) was identified as a new oncogene in ESCC. IL-1β and its receptor IL-1R1 highly expressed in ESCC, especially in tumor cells. FREM2 was induced by IL-1β, and in turn bound to and stabilized IL-1R1, facilitating IL-1β signal transduction. The activation of downstream NK-κB and JNK signals mediated the tumor-promoting effect, while the reduction of FoxP1 was responsible for IL-1β-induced FREM2 transcription. High levels of FREM2 and IL-1R1 synergistically indicated the shorter survival time in patients. Conclusion These results suggest FREM2 is an IL-1β-stimulated oncogene, which as a cofactor of IL1R1 promotes IL-1β-induced ESCC progression. Therapeutic strategies targeting FREM2 is likely to prolong the survival of ESCC patients.
Shared microbial community changes in female rats and humans with Rett syndrome
Authors: Gallucci Allison , Patterson Kelsey , Weit Abigael , Pol William Van Der , Dubois Laura , Percy Alan , Morrow Casey , Campbell Susan , Olsen Michelle L
Published: December 2019

Background Rett syndrome (RTT) is an X-linked neurodevelopmental disorder predominantly caused by alterations of the methyl-CpG-binding protein 2 (MECP2) gene. The gut microbiome has been implicated in neurodevelopmental disorders such as Autism Spectrum Disorder (ASD) as a regulator of disease severity. Although the gut microbiome has been previously characterized in humans with RTT, the impact of MECP2 mutation on the composition of the gut microbiome in animal models where the host and diet can be experimentally controlled remains to be elucidated.Methods We evaluated the microbial community through 16S sequencing of fecal samples collected across postnatal development as behavioral symptoms appear and progress in a novel zinc-finger nuclease rat model of RTT. Additionally, we profiled fecal levels of fatty acids in MecP2 deficient rats. Lastly, we compared our results to predicted functional shifts in the microbiota of females with RTT compared to their mothers to further examine the translational potential of the current RTT rat model.Results We have identified microbial taxa that are differentially abundant across key timepoints in a zinc-finger nuclease rat model of RTT compared to WT. Furthermore, we have characterized functional categories of gut microbes that are similarly affected in females with RTT and female RTT rats, including similar alterations in pathways related to short chain fatty acid (SCFA) activity. Lastly, we have demonstrated that SCFA levels are decreased in the feces of RTT rats compared to WT.Limitations The current study is potentially limited by age related differences in the microbiome of RTT participants and controls as well as medication effects on the microbiome. Additionally, the current study did not assess male MeCP2-deficient rats, and it may be relevant in future studies to address potentially disparate microbial changes in male and female rats and humans with RTT.Conclusions The results of our studies establish distinct microbial community shifts that occur in RTT across developmental time points independently of diet or environmental factors. We identify p105 as a key translational timepoint at which microbial shifts most closely mirror reported microbiota communities in RTT patients. Overall, these results represent an important step in translational RTT research.
Clinical characteristics of immune tolerance after pediatric liver transplantation
Authors: Gao Kai , Liu Shuang Qing , Guo Chunbao
Published: December 2019

Objective This study aimed to investigate the clinical characteristics of immune tolerance after pediatric liver transplantation and to identify the possible predictors.Methods The clinical data from 37 cases of pediatric patients who underwent liver transplantation surgery in the Children's Hospital of Chongqing Medical University, China, were retrospectively analyzed. According to the status of the current immunosuppressant medications of the patients, they were divided into no-drug (n=4), single-drug (n=16) and multi-drug (n=17) groups. The possible influencing factors were screened based on these clinical data.Results The factors that differed among the groups included the age at transplant and the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of the transplant recipients. Between the single-drug group and the multi-drug group, the age, ALT level, and AST level of the transplant recipients were significantly different (P=0.01, P=0.00, and P=0.02, respectively); only the ALT level was significantly different (P=0.04) between the no-drug group and the multi-drug group. No significant difference was found in various factors between the no-drug and single-drug groups.Conclusion The age of the recipient at transplant may be a potential factor affecting the generation of clinical immune tolerance in pediatric liver transplantation, while ALT and AST levels can be used as potential predictors of the generation of postoperative immune tolerance.
Patient satisfaction after Elective Major Gynaecological Surgery in 2 reference hospitals in Yaounde: A cross-sectional study
Authors: AKOMBENG Ojong Samuel , Bain Luchuo Engelbert , Nsahlai Christiane , Tarkang Elvis E. , Kingsley Ombaku , Alice Mapina M. , Mathias Gouané , Pascal Foumane
Published: December 2019

Introduction Patient satisfaction is a quality of care measure and reveals patients’ appreciation of healthcare delivery. We sought to measure patient satisfaction following major gynaecological surgeries in 2 University Teaching Hospitals in Yaounde, Cameroon.Methods Ours was a cross-sectional, prospective study over 9 months (October 1 st 2018, to June 30 th 2018) at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH) and the Yaounde Central Hospital (YCH). By administering a modified Surgical Satisfaction Questionnaire (SSQ-8) via phone call 6 months after surgery we appreciated and scored key aspects linked to patient satisfaction, and obtained information on post-operative complications. Data was analysed using Microsoft Excel 18 and SPSS 21 setting significance at p<0.05.Results We recruited 72 patients aged 24 to 68 years. Our participants had a mean satisfaction score of 26 ± 7.854 (59.7% satisfied and 40.3% dissatisfied). All aspects tested on the SSQ-8 questionnaire influenced patient satisfaction. Patients who said they were satisfied with pain control after surgery (OR=0.207 CI=0.070–0.609, P=0,003), and with surgical results in the SSQ-8 questionnaire (OR=0.053, CI=0.011–0.254, P<0.001) achieved statistically significant post-operative satisfaction. Contrarily, patients who were dissatisfied with surgery results (OR=132.000, CI=15.256-114.131, P< 0.001) and those who developed complications (OR=7.922, CI=2.241 – 28.004, P<0.001) were significantly dissatisfied with surgery. Additionally, 47.2% declared a poor post-operative current health status versus 52.8% who claimed a good post-operative current health status. Following multivariate analysis, satisfaction with the results of surgery (aOR= 0.071, CI=0.008–0.657, P= 0.020) and the occurrence of complications (aOR=7.284, CI=1.146 – 46.273, P=0.035) were the main determinants of patient satisfaction. Patient current health status evolved similarly to patient satisfaction and especially by satisfaction with time taken to resume work (aOR=0.039, CI=0.004-0.398, P=0.006) and pre-operative exercise routine (aOR=0.038, CI=0.002–0.678, P-value=0026).Conclusion Patient satisfaction with elective gynaecological surgery is low and determined by post-operative experiences and the occurrence of complications. Also, patient self-reported current health status tends to evolve similarly to satisfaction following surgery.
Relato de experiência do projeto de extensão: Primeiros Socorros: educando a comunidade e os profissionais de saúde do município de Viçosa-MG e região
Authors: Diaz Flávia Batista Barbosa de Sá , Alves Sarah De Moraes , Godinho Aline Aparecida de Souza , Oliveira Gabriella Machado de Sousa , Ferreira Marina Talma Torres Santos , Carneiro Nicoli Souza
Published: December 2019

Objetivo: relatar a experiência dos membros do projeto “Primeiros Socorros: educando a comunidade e os profissionais de saúde do município de Viçosa-MG e região” na realização de intervenções educativas. Metodologia/procedimentos: relato de experiência dos participantes do projeto de extensão que atualmente conta com uma equipe com 17 membros. Os temas abordados nas intervenções educativas foram pequenas urgências, parada cardiorrespiratória e atendimento pré-hospitalar. Para avaliar a qualidade das capacitações foram aplicados pré e pós testes. Resultados e Discussão: no período de março a outubro de 2018 foram realizadas 04 reuniões organizacionais, 02 oficinas educativas e 10 capacitações totalizando 226 participantes de públicos diversos. Conclusões: realizar capacitações é imprescindível pois os participantes relataram maior compreensão e segurança para atuar nos primeiros socorros de situações emergenciais.
Desarrollo de nanomaterial con carbón activado de vástago de banano
Authors: Quintero Ruiz Esdras Nahum , Giraldo Toro Efrén , Acevedo Álvarez Carlos Alberto
Published: December 2019

En este trabajo se presenta el proceso de desarrollo de un material poroso a partir de carbón activado con ácido fosfórico, obtenido del vástago de banano criollo. La capacidad de adsorción es establecida mediante método estático, se evalúan 5 puntos en los cuales el carbón es sometido a diferentes porcentajes de humedad. Se hizo el análisis del área superficial (Sbet) del carbón obtenido y se establece su valor mediante el método B.E.T.El desarrollo de este nanomaterial amplía las posibilidades de investigación en campos como la refrigeración, en la que se usa como fuente de energía la radiación solar y en la electrónica se aprovecha la mayor área superficial de los carbones activados para construir súper condensadores, de manera que se coloca el carbón entre las placas paralelas, lo que hace que estos dispositivos presenten una capacitancia miles de veces mayor que la de los condensadores actuales de alta capacidad
Factors that affect customer loyalty in small enterprises
Authors: Worku Zeleke
Published: December 2019

The study was conducted by collecting the data from 608 customers of migrant retailers working in the retail industry of Pretoria West in South Africa in order to identify socioeconomic factors that affect customer loyalty. Data was collected from eligible respondents by using a pre-tested, validated and standardised questionnaire of study that was self-administered by respondents. The study found that about 69% of customers were loyal to their retailers. About 68% of customers had a favorable attitude towards their retailers. About 68% of retailers used appropriate promotional measures for marketing their goods to potential customers. About 69% of retailers provided their customers with satisfactory quality of services. About 67% of customers were loyal to their retailers’ brands. Factor analysis was used for extracting 3 influential predictors of customer loyalty. These factors were entrepreneurial skills, marketing skills, and selling price. The percentage of variance explained by the 3 extracted factors was equal to 92.58%.
ENFERMEIRO DE BORDO A ASSISTÊNCIA EM OBSTETRÍCIA NO TRANSPORTE AEROMÉDICO: UMA REVISÃO NARRATIVA
Authors: De Oliveira Elia Machado , Ferreira Wellington Fernando da Silva , Dutra Denecir De Almeida
Published: December 2019

A presente revisão objetivou-se, identificar as principais atribuições do profissional enfermeiro de bordo durante o transporte aéromédico e sua dinâmica assistencial no processo gravidico em remoção. A matriz metodológica, tratou-se de um estudo descritivo exploratório qualitativa através de uma revisão narrativa de literatura, realizou-se a busca de estudos em periódicos nacionais: SCIELO, LILACS, BIREME, BVS, publicados entre os anos de 2013 ao primeiro semestre de 2018, o recorte temporal justifica-se pela escassez de literatura na dimensões proposta desta temática, dessa forma, na última fase de seleção, realizada a leitura integral de todos os manuscritos, e amostra final constituída por 16 textos científicos. Os principais resultados evidenciados apontam eixos da temática analisada, o papel do enfermeiro de bordo no atendimento pré-hospitalar durante o transporte aeromédico, avaliação as condições do paciente em processo gravídico, com eximia assistência por meio de protocolos, além de habilidade e capacitação necessária para a remoção e intercorrências em voo. Portanto transporte aeromédico é uma atividade em desenvolvimento no Brasil, e sua temática deve ser aprofundada para o seu conhecimento especifico, corroborando a rápidas intervenções no processo de remoção de paciente e estado crítico de emergência.
PRINCIPAIS FATORES DE RISCO PARA A MANUTENÇÃO DO ALEITAMENTO MATERNO EXCLUSIVO NO BRASIL E EUA
Authors: Santiago Letícia Alessandra , Hissayassu Sérgio Augusto Yukio , Comuni Paula Moura Del
Published: December 2019

Identificar, por meio de revisão bibliográfica nacional e internacional, os principais fatores responsáveis pelo Desmame Materno Precoce (DMP) no Brasil e nos Estados Unidos da América (EUA) e estabelecer uma análise comparativa entre ambos. Estudo descritivo, baseado em revisão de literatura, a partir de artigos citáveis nos idiomas português e inglês, disponíveis nas bases de dados Scientific Electronic Library Online (Scielo) e Public Medline (PubMed), publicados entre os anos de 2003 e 2017, na área temática Ciências da Saúde. Na PubMed, utilizou-se o descritor Exclusive breastfeeding, sendo encontrados 60 manuscritos. Já na Scielo, com a conjugação dos descritores Aleitamento Materno e Desmame, observou-se 49 trabalhos. Observou-se que o retorno da mãe ao mercado de trabalho foi um dos principais fatores de risco para o DMP em ambos os países. Contudo, no Brasil o amparo legal oferecido pela licença maternidade refletiu em 41% de Aleitamento Materno Exclusivo (AME) até os seis meses, enquanto nos EUA, a ausência desse direito conferiu média nacional de apenas 8% para o AME. O estudo demonstrou que o amparo legislativo tem impacto positivo na adesão das mães ao AME ao colaborar na interação entre o binômio mãe-filho, estimulando a prática da amamentação.
TRANSLATION, TRANSCULTURAL ADAPTATION, VALIDATION OF THE HOLISTIC CRITICAL THINKING SCORING RUBRIC TO BRAZILIAN PORTUGUESE
Authors: Riegel Fernando , Crossetti Maria Da Graça Oliveira
Published: December 2019

Objective: translation, transcultural adaptation, and validation of the Holistic Critical Thinking Scoring Rubric, original from the United States, to Brazilian Portuguese. Method: methodological study comprising the following steps: translation by 3 independent translators, transcultural adaptation by a Committee of 6 Nurses Experts; and validation, with the participation, in the pre-test, of 30 academics and 3 teachers-evaluators of Nursing field. The validity and reliability of the tool were verified by Kappa test. Results: the Portuguese version of the tool obtained a Kappa test score of 0.82 in the pre-test group. There was strong significant agreement among the evaluators. Conclusion: The Brazilian version of the Holistic Critical Thinking Scoring Rubric is a valid and reliable tool to evaluate the holistic critical thinking of Nursing academics at different levels of training, especially using active teaching methodologies.
AUTOMEDICAÇÃO EM IDOSOS: MEDIDAS DE PREVENÇÃO E CONTROLE
Authors: Pereira Rocha Beserra Fernanda Lorena , Borba Valéria Ferreira da Costa , Torres Jáfia Elana Gonçalves , Da Silva Sara Nayara Duarte , Sobreira Macedo Mellyssa Ayêska Custodio
Published: December 2019

RESUMO 

Os medicamentos são considerados essenciais para os cuidados com a saúde, os quais colaboram para se obter uma melhora significativa no estado de saúde das pessoas, nos casos em que o utilizam de modo racional. Os idosos são os que mais consomem medicamentos sem prescrição. Diante desse cenário, o profissional farmacêutico é visto como sendo um profissional de saúde de fácil acesso, o qual é encontrado em quase todas as farmácias do país. O objetivo desse estudo foi analisar a prevenção e o controle da automedicação no público idoso e a identificação das medidas de prevenção e controle da automedicação. Trata-se de uma Revisão Integrativa da Literatura realizada na Biblioteca Virtual de Saúde (BVS), onde foram usados os descritores indexados nos Descritores em Ciências da Saúde (DECS) “Automedicação” e “Idoso”. A busca foi realizada no período de fevereiro e março de 2018, e foram encontradas doze publicações na pesquisa, onde após os critérios de inclusão restaram nove trabalhos relacionados à temática. Os resultados mostraram que. As principais medidas identificadas de controle e prevenção da automedicação em idosos foram à atuação da equipe de saúde, dando destaque ao farmacêutico, na divulgação de informações e esclarecimentos quanto aos riscos da automedicação através da adoção de práticas educativas e o uso de recurso midiático para divulgação, protocolos clínicos e listas de medicações e suas especificidades. Contudo, a limitação do estudo deu-se por um quantitativo reduzido de produções, assim, sugerem-se estudos mais amplos que abordem essa temática, incluindo outros públicos e outros contextos.
SAÚDE E AUTOCUIDADO ANTE A SITUAÇÕES DE ESTRESSE DURANTE A FORMAÇÃO ACADÊMICA
Authors: Ribeiro Elaine Rossi , Raieski Bruna Santi , Machado Vinícius Kletemberg
Published: December 2019

Os estudantes de medicina estão expostos a diversos estressores durante a formação que afetam tanto a saúde mental e física como o rendimento acadêmico e são diversas as formas de enfrentamento. O estudo objetivou apreender a percepção dos estudantes de medicina sobre o estresse vivenciado durante a formação e as formas de enfrentamento. Foi realizada uma pesquisa do tipo estudo de caso, com abordagem qualitativa, com estudantes de medicina. Para análise e discussão utilizou-se a análise dos discursos, e em cada categoria agruparam-se as Unidades de Significação que contemplavam questões correlacionadas. Foi apreendido dos estudantes uma percepção semelhante quanto aos fatores estressores e as repercussões deste para a saúde e o rendimento acadêmico. Evidenciou-se também a necessidade de intervenção por parte dos estudantes e principalmente das instituições e corpo docente incentivando a busca do equilíbrio entre estudo e lazer.
Media Pembelajaran Matematika SMP Berbasis Android Berorientasi UoS untuk meningkatkan Hasil Belajar Siswa
Authors: Rohman Ahmad Aunur , Ismail M. , Siswanah Emy
Published: December 2019

Terdapat keterbatasan sumber belajar siswa dan sarana pembelajaran yang terdapat di SMP Negeri 1 Kendal. Penelitian ini dimaksudkan untuk menjawab permasalahan tersebut, dengan tujuan untuk mengetahui apakah media pembelajaran matematika SMP berbasis android berorientasi UoS pada materi lingkaran dapat meningkatkan hasil belajar siswa. Jenis penelitian ini adalah kuantitatif. Penentuan sampel menggunakan teknik purposive sampling dengan pertimbangan nilai pretest terendah yaitu kelas VIII G sebanyak 30 siswa. Hasil penelitian menunjukkan bahwa media pembelajaran Matematika SMP berbasis android berorientasi UoS dapat meningkatkan hasil belajar siswa.
A simple, robust, and automatic approach to extract water body from Landsat images (case study: Lake Urmia, Iran)
Authors: Babaei Hadiseh , Janalipour Milad , Tehrani Nadia Abbaszadeh
Published: December 2019

Lake Urmia is one of the largest saline lakes in the world, and has a great effect on its surrounding ecosystems as well as the economic, social, and even cultural condition of its basin inhabitants. Hence, continuous monitoring of lake area changes is necessary and unavoidable for better land management and prevention of its degradation. In this study, by using Landsat 8 images and by preforming some essential pre-processing tasks, the area of the lake was estimated using the number of traditional spectral indices and a new one and the automatic Otsu's thresholding method for 5 years (2013–2017). The results showed that this index shows more accurate results than other indices when estimating the area of the lake and can separate water class from land one with an average overall accuracy of 96%.
The Significance of Buffer Solutions on Corrosion Processes of Cobalt Ferrite CoFe2O4 Thin Film on Different Substrates
Authors: Elsayed Elsayed M. , Khalil Hazem F. , Ibrahim Ibrahim A. , Hussein Mostafa R. , El-Sabbah Mohamed M.B.
Published: December 2019

Background:

The spinel ferrite nanoparticles, such as zinc, nickel, and cobalt ferrites have exceptional electronic and magnetic properties. Cobalt ferrite nanomaterial (CoFe2O4) is a hard material that reveals high magnetic, mechanical, and chemical stability.

Aim and Objective:

The objective of this research is to predict the corrosion behavior of cobalt ferrite (CoFe2O4) thin films deposited on different substrates (platinum Pt, stainless steel S.S, and copper Cu) in acidic, neutral, and alkaline medium.

Materials and Method:

Cobalt ferrite thin films were deposited on platinum, stainless steel, and copper via electrodeposition-anodization process. After that, corrosion resistance of the prepared nanocrystalline cobalt ferrite on different substrates was investigated in acidic, neutral, and alkaline medium using open circuit potential and potentiodynamic polarization measurements. The crystal structure, crystallite size, microstructure, and magnetic properties of the ferrite films were investigated using a combination of XRD, SEM and VSM.

Results:

The results of XRD revealed a cubic spinel for the prepared cobalt ferrite CoFe2O4. The average size of crystallites was found to be about 43, 77, and 102 nm precipitated on platinum, stainless steel, and copper respectively. The magnetic properties of which were enhanced by rising the temperature. The sample annealed at 800oC is suitable for practical application as it showed high magnetization saturation and low coercivity. The corrosion resistance of these films depends on the pH of the medium as well as the presence of oxidizing agent.

Conclusion:

Depending on the obtained corrosion rate, we can recommend that, CoFe2O4 thin film can be used safely in aqueous media in neutral and alkaline atmospheres for Pt and Cu substrates, but it can be used in all pH values for S.S. substrate.
Novel Techniques for Classification of Lung Nodules using Deep Learning Approach
Authors: Bhavanishankar K. , Sudhamani M. V.
Published: December 2019

Objective:

Lung cancer is proving to be one of the deadliest diseases that is haunting mankind in recent years. Timely detection of the lung nodules would surely enhance the survival rate. This paper focusses on the classification of candidate lung nodules into nodules/non-nodules in a CT scan of the patient. A deep learning approach –autoencoder is used for the classification.

Investigation/Methodology:

Candidate lung nodule patches obtained as the results of the lung segmentation are considered as input to the autoencoder model. The ground truth data from the LIDC repository is prepared and is submitted to the autoencoder training module. After a series of experiments, it is decided to use 4-stacked autoencoder. The model is trained for over 600 LIDC cases and the trained module is tested for remaining data sets.

Results:

The results of the classification are evaluated with respect to performance measures such as sensitivity, specificity, and accuracy. The results obtained are also compared with other related works and the proposed approach was found to be better by 6.2% with respect to accuracy.

Conclusion:

In this paper, a deep learning approach –autoencoder has been used for the classification of candidate lung nodules into nodules/non-nodules. The performance of the proposed approach was evaluated with respect to sensitivity, specificity, and accuracy and the obtained values are 82.6%, 91.3%, and 87.0%, respectively. This result is then compared with existing related works and an improvement of 6.2% with respect to accuracy has been observed.
Segmentation of Brain Tumor and Performance Evaluation Using Spatial FCM and Level Set Evolution
Authors: Sreerangappa M. , Suresh M. , Jayadevappa D.
Published: December 2019

Background:

In recent years, brain tumor is one of the major causes of death in human beings. The survival rate can be increased if the tumor is diagnosed accurately in the early stage. Hence, medical image segmentation is always a challenging task of any problem in computer guided medical procedures in hospitals. The main objective of the segmentation process is to obtain object of interest from the given image so that it can be represented in a meaningful way for further analysis.

Methods:

To improve the segmentation accuracy, an efficient segmentation method which combines a spatial fuzzy c-means and level sets is proposed in this paper.

Results:

The experiment is conducted using brain web and DICOM database. After pre-processing of an MR image, a spatial FCM algorithm is applied. The SFCM utilizes spatial data from the neighbourhood of each pixel to represent clusters. Finally, these clusters are segmented using level set active contour model for the tumor boundary. The performance of the proposed algorithm is evaluated using various performance metrics.

Conclusion:

In this technique, wavelets and spatial FCM are applied before segmenting the brain tumor by level sets. The qualitative results show more accurate detection of tumor boundary and better convergence rate of the contour as compared to other segmentation techniques. The proposed segmentation frame work is also compared with two automatic segmentation techniques developed recently. The quantitative results of the proposed method summarize the improvements in segmentation accuracy, sensitivity and specificity.
Method Development and Validation for Simultaneous Estimation of Benidipine Hydrochloride and Metoprolol Succinate in Tablet
Authors: Patel Dhaval M , Patel Deepa , Patel Advaita , Sheth Avani , Shah Utsav J
Published: December 2019

Present work focusing in developing and validating a new high performance liquid chromatography method for estimation of Metoprolol Succinate and Benidipine Hydrochloride in their combine tablet dosage form. The method was performed on Shimadzu LC-20AT instrument using C18 (250 mm x 4.6 mm, 5 µm) Hypersil BDS Column and Potassium Dihydrogen Phosphate Buffer (pH 4.0): Methanol (65: 35% v/v) as mobile phase at ambient temperature. Detection was carried out at 269 nm. Concentration range 4-12 µg/ml for Benidipine Hydrochloride and 25-75 µg/ml for Metoprolol Succinate . The Percentage recovery of Benidipine Hydrochloride and Metoprrolol succinate was found to be 99.59% and 99.39 respectively. Correlation coefficient for Metoprolol succinate and Benidipine Hydrochloride was found 0.9995 and 0.9997 respectively. The Rt values for Metoprolol succinate and Benidipine Hydrochloride were found to be 3.4 and 5.9 min respectively. The method was validated according to the guidelines of International Conference on Harmonisation (ICH) and was successfully employed in the estimation of commercial formulations.

Keywords:  Metoprolol Succinate, Benidipine Hydrochoride, HPLC, Mobile Phase,
Spectrochemical Investigation of di methoxy Aniline Dithiocarbamate metal complexes-Biological activity
Authors: Soma sekhar A , Jayaraju A. , Sreeramulu J.
Published: December 2019

Dithiocarbomates are a class of sulfur-based metal-chelating compounds commonly used in industry, agriculture, and medicine. 2,6 di methoxy Aniline dithiocarbamate  Complexes of Copper and Ruthenium have been prepared  and Characterized by Spectroscopic methods like IR,NMR and also analysis of Biological activity. The investigation of these complexes confirmed that the stability of metal–ligands coordination through, S & S,N atoms as bidendate chelates..
Identifying Medication Errors in a Tertiary Care Teaching Hospital: A Prospective Observational Study
Authors: Reddy Peddolla Sushma , Biju Vidya , Bhavana Inuganti
Published: December 2019

Background: Medication error is defined as any avertable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the health care professional, patient and consumer. Medication errors may occur at any stage of the medication use process including ordering, transcription, dispensing, administering and monitoring. 

Objective: The objective of the study is to assess the medication errors in a tertiary care hospital and to categorize them based on their nature and type.

Methodology: A prospective observational study was conducted over a period of 3 months in a tertiary care teaching hospital. This study was carried out among 240 inpatients, admitted in General Medicine department of the hospital, who were selected randomly. During the study, inpatients case records were reviewed, which includes patient’s case history, diagnosis, medication order sheets, progress chart, laboratory investigations. The data collected were analyzed for identifying medication errors such as prescribing errors and administration errors. Each reported medication error was assessed using the National Coordinating Council for Medication Error Reporting and Prevention (NCCMERP) proposed index for categorizing medication errors.

Results: A total number of 240 inpatients were enrolled in the study, out of which 82 patients have developed medication errors. The overall percentage of observed medication error was 34.16%. In our study medication errors were found more in males (70.7%) than in the females (29.3%). Prescribing errors (62.19%) were the most frequently occurring type of error, which was followed by administration errors (37.8%). In our study, we found that medication errors were more with antibiotics (37) followed by NSAIDs (19). 96 prescriptions were found having drug interactions. Conclusion: This study concludes that the overall incidence of medication error was found to be 34.16%. Most of the medication errors are clinically significant and it can prevent by working together in a health care team.
INDICADORES E ÍNDICE GERAL DE SUSTENTABILIDADE DO CSC-UFSB: procedimentos metodológicos
Authors: Farias Livia Berti Sanjuan , Costa Silvia Kimo , Gomes Ronaldo Lima
Published: December 2019

O presente artigo apresenta a metodologia desenvolvida para avaliar a sustentabilidade do Campus Sosígenes Costa (CSC) da Universidade Federal do Sul da Bahia (UFSB), localizado no município de Porto Seguro, BA. A metodologia contemplou seis etapas: 1a etapa - estudo de revisão sistemática. 2a etapa - elaboração da matriz de referência 1 contendo indicadores preliminares com base no Environmental Key Performance Indicators - EKPIs e no Graphical Assessment of Sustainability in Universities (GASU). 3a etapa - elaboração da matriz de referência 2 contendo aspectos gerais, sub-aspectos e o conjunto efetivo de indicadores (que permitem mensurar a sustentabilidade do CSC - UFSB) vinculados a cada sub-aspecto. 4a etapa - elaboração da matriz de referência 3 constando o sub-aspecto, os indicadores efetivos e a pontuação (score) que permite mensurar se o sub-aspecto analisado, por meio dos indicadores, apresenta sustentabilidade ou não. 5ª etapa - elaboração da matriz de referência 4 contendo as fórmulas para cálculo das médias aritméticas dos indicadores contemplados por aspecto geral. E 6ª etapa - elaboração da fórmula para cálculo do Índice Geral de Sustentabilidade (IGS) do CSC-UFSB. A metodologia desenvolvida pode ser adaptada para a realidade de qualquer outra Instituição de Ensino Superior.
PROPOSIÇÕES PARA UM MOVIMENTO MENOR
Authors: André Arias  , Erin Manning
Published: December 2019

As proposições deste texto são orientações de um processo curatorial experimental em curso durante o ano de 2019, e que serve como o ativador da série de encontros que o SenseLab facilitará em diferentes países com o título de Movimentos Menores. Na exploração transversal do que essa série de encontros pode gerar, emerge a pergunta de como é possível dar conta da entrada do movimento menor no mundo. Um processo curatorial para a ativação de movimentos menores requer uma transformação do pressuposto de que existe um campo da arte e um campo da vida, quando o binarismo entre arte e vida é desfeito. O que importa não é se é ou não arte, mas como a experiência ou o acontecimento muda as condições da experiência. Quando a arte se torna a maneira e não o fim, os movimentos menores se tornam orientadores dos processos por vir.
Perguntas, respostas e pressupostos: uma proposta metodológica para o estudo do espaço
Authors: Oliveira Felipe Souza Leão de
Published: December 2019

O objetivo deste artigo é construir uma abordagem capaz de lidar com o problema do espaço em textos historiográficos, usando principalmente as obras dos historiadores Hayden White e Robin George Collingwood. Primeiro, articulamos o método de análise de pressuposições de White com a lógica de perguntas e respostas de Collingwood. Por fim, concluímos com uma demonstração prática de nossa abordagem, analisando os textos dos escritores brasileiros Luís da Câmara Cascudo e Gilberto Freyre a respeito de dois espaços: o “Brasil Holandês” e o “Nordeste”.
O libertino e os usos do passado antigo: ensaio sobre a relação de Hancarville com o passado Romano (1780)
Authors: Cozer Alexandre
Published: December 2019

Pierre-François Hugues, ou Barão de Hancarville, foi um antiquarista dedicado ao estudo de cerâmicas cujo trabalho foi desenvolvido sobretudo na baía de Nápoles, no século XVIII, quando se começava a escavar Pompeia e Herculano. Embora esse autor tenha uma obra de relevância para os estudiosos de cerâmica da Antiguidade Clássica, Hancarville também foi autor de obras menos técnicas dedicadas ao estudo de monumentos falsos e dos hábitos sexuais mais curiosos dos antigos Romanos. Nesse artigo, intencionamos realizar um estudo sobre a maneira como o autointitulado Barão se apossava do passado Clássico, em obras falsas e de caráter libertino, para gerar uma reflexão que atingia também o seu presente. Para tanto, empreenderemos, primeiro, uma discussão sobre os estudos de Usos do Passado no Brasil e de que maneiras nos vale se aproximar dessa forma de pensar a Arqueologia e a História. Em um segundo momento, buscaremos pensar a maneira como se conforma o pensamento do estudioso sobre a Antiguidade e sobre a sexualidade. Intencionamos, com isso, mostrar que mesmo em se tratando de monumentos inventados, o antiquarista desenvolvia um pensamento fundamentado na leitura de documentação e na análise próxima à historiografia. Que seu pensamento tenha ficado de lado, ou que tenha influenciado unicamente teorias mais críticas sobre o passado, aponta para algumas das exclusões com as quais se formou a disciplina de História Antiga.
A memória em trânsito: Uma leitura da Via Sacra enquanto construção coletiva
Authors: Nascimento Renata Cristina de Sousa
Published: December 2019

Tendo por guia a obra de Maurice Halbwachs “La topographie légendaire des évangiles en Terre Sainte”, pretendo discutir a constituição dos lugares-memória do cristianismo, dando destaque à Via Sacra. Revisitando estes lugares o passado se reatualiza na memória coletiva, fortalecendo a religião cristã. A tradição presente nestes espaços fundantes é a base do cenário histórico -religioso, que foi e é constantemente revivido em diversas regiões. A via-crucis é exemplo claro desta rememoração intensa, estando presente também no imaginário religioso e artístico brasileiro. As representações artísticas da Via Sacra contribuem para o fortalecimento do patrimônio simbólico, e são elementos fundamentais na reinvenção de uma toponímia sagrada. O objetivo deste artigo é apresentar alguns elementos desta tradição em consonância com o conceito de memória coletiva. Na tradição cristã lugares, imagens e objetos serviram como elementos de “reevocação” de um passado memorável, que se desejava perpetuar.
Sertão das “muié séria”? Convenções de gênero e rebeldia feminina em processos judiciais em Jacobina (BA)
Authors: Vasconcelos Tânia Mara Pereira
Published: December 2019

Historicamente, as representações de gênero ligadas ao sertão foram perpassadas por estereótipos que associam o masculino aotrabalho duro, à virilidadee à valentia, enquantoo feminino é associado à ideia de submissão, seriedade edeserotização. A proposta do artigo é dialogar com algumas dessas representações que aparecem cristalizadas em manifestações culturais produzidas no Nordeste brasileiro, procurandoconfrontá-las com discursos e práticas que emergem da análise de fontes históricas específicas. A partir da análise de processos judiciais por crime contra os costumes e jornais do município de Jacobina, na Bahia, nas décadas de 1940 e 1950, foi possível observar que, embora os valores patriarcais fossem predominantes nos discursos, eles foram constantemente subvertidos nas vivências cotidianas de homens e mulheres sertanejos/as. Destaca-se que o binarismo de gênero, que instituiu uma rígida oposição entrehomens e mulheres, embora seja tradicionalmente associado à uma visão de mundo “atrasada”,típica de sociabilidades rurais, foi construído e legitimado a partir de um projeto de modernidade conservadora, embasado pela ciência europeia. Tal projeto instituiu o casamento como norma e justificou o aprisionamento do sexo ao casamento. Em Jacobina, a divulgação desse ideal se deu justamente em um período de grande desenvolvimento econômico, devido à redescoberta do ouro no município. Nesse contexto emergiu um projeto de higienização e policiamento dos costumes, que associava um ideal de modernidade ao de moralidade. Na contramão desse projeto, que reforçava o ideal de pureza feminina e conjugalidade normativa, moças jacobinenses, ousaram desafiar a autoridade paterna e viveram seus desejos, sem se deixaremaprisionar pelo modelo de feminilidade casta,doce e resignada propagadopelas camadas dominantes e relativamente compartilhado em seu meio social.
Üzleti intelligencia megoldások alkalmazásának sikertényezői - A hazai szolgáltató szektor nagyvállalatainak körében végzett mélyinterjús kutatás
Authors: Görcsi Gergely , Barta Gergő , Széles Zsuzsanna
Published: December 2019

A vállalatok működése szempontjából a döntéstámogató funkció folyamatos fejlesztése, monitorozása kiemelt jelentőségű, hiszen az vezetést támogató eszközként segíti a menedzsmentfeladatok ellátását. Az üzleti intelligencia (business intelligence, BI) olyan infokommunikációs megoldás, mely a vállalati rendszerekből különböző adatforrásokat felhasználva képes az adatok összekapcsolására és elemzésére. A napi üzletmenet gördülékeny biztosítása céljából alkalmazott tranzakciós rendszerektől eltérően a BI-eszközök beszámolás orientáltak, a fókusz a döntéstámogatásra helyeződik. A kutatás a fogalmak tisztázását követően képet ad a legfrissebb üzleti intelligencia trendekről. A tanulmány szakmai mélyinterjúk elemzésén keresztül betekintést nyújt az üzleti intelligencia megoldások világába. A kutatás eredményeként az olvasó képet kaphat a BI bevezetésétől várt eredményekről, az implementáció és a hosszú távú működtetés sikerkritériumait illetően.

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Gergely GORCSI - Gergo BARTA - Zsuzsanna SZELES

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Mađarska revolucija 1956. u svjetlu hrvatskoga tiska
Authors: Šokčević Dinko
Published: December 2019

U ovom radu prikazan je odjek mađarske revolucije 1956. u hrvatskom tisku onoga vremena. Rad se uglavnom fokusira na članke i izvješća iz same 1956. godine, djelomično već od ljeta uoči izbijanja revolucije, najviše prostora posvećuje novinskim napisima iz vremena događaja (listopad, studeni, prosinac), a dijelom obuhvaća i napise u tisku iz prvih mjeseci 1957. godine. U radu se prikazuje i analizira odjek mađarskih zbivanja i u vodećim listovima Narodne Republike Hrvatske (Vjesnik, Narodni list), ali isto toliko važnosti pridaje se i člancima u tiskovinama hrvatske emigracije (Hrvatska revija, Hrvatska država, Hrvatski glas i drugi). Istodobno se rad osvrće i na splet tadašnjih jugoslavensko-mađarskih i jugoslavensko-sovjetskih odnosa.
On degenerate central complete bell polynomials
Authors: Kim Taekyun , Kim San , Jang Gwan-Woo
Published: December 2019

In this paper, we consider of generalized central complete and incomplete
Bell polynomials called degenerate central complete and incomplete Bell
polynomials. These polynomials are generalizations of the recently
introduced central complete Bell polynomials and `degenerate' analogues for
the central complete and incomplete Bell polynomials. We investigate some
properties and identities for these polynomials. Especially, we give
explicit formulas for the degenerate central complete and incomplete Bell
polynomials related to degenerate central factorial numbers of the second
kind.
A globally convergent modified version of the method of moving asymptotes
Authors: Guessab Allal , Driouch Abderrazak , Nouisser Otheman
Published: December 2019

A new modified moving asymptotes method is presented. In each step of the
iterative process, a strictly convex approximating subproblem is generated
and explicitly solved. In doing so we propose a strategy to incorporate a
modified second-order information for the moving asymptotes location. Under
natural assumptions, we prove the geometrical convergence. In addition the
experimental results reveal that the present method is significantly faster
compared to the [1] method, Newton's method and the BFGS Method.
A-statistical convergence of order α via φ - function
Authors: Savas Ekrem
Published: December 2019

In this paper, we introduce and examine some properties of A-statistical
convergence of order ? by using ? - function, modulus function and
generalized three parametric real matrix A.
Meir-Keeler type and Caristi type fixed point theorems
Authors: Pant Abhijit , Pant R.P. , Rakocevic Vladimir
Published: December 2019

Agarwal et al [1] have proved some interesting local and global fixed point
theorems for Meir-Keeler [7] type and Caristi [2] type maps. We obtain
analogues of the main results of Agarwal et al [1] under weaker conditions
so as to include continuous as well as discontinuous maps. Our results
provide new answers to Rhoades' problem ([15], p. 242) on existence of
contractive definitions which admit discontinuity at the fixed point. Several
examples are given to illustrate our results.
Numerical approximation of young-measure solutions to parabolic systems of forward-backward type
Authors: Caddick Miles , Süli Endre
Published: December 2019

This paper is concerned with the proof of existence and numerical
approximation of large-data global-in-time Young measure solutions to
initial-boundaryvalue problems for multidimensional nonlinear parabolic
systems of forward-backward type of the form ?tu - div(a(Du))+ Bu = F,
where B ? Rmxm, Bv?v ? 0 for all v ? Rm, F is an m-component
vector-function defined on a bounded open Lipschitz domain ? ? Rn, and a is a
locally Lipschitz mapping of the form a(A)= K(A)A, where K: Rmxn ? R. The
function a may have unequal lower and upper growth rates; it is not assumed
to be monotone, nor is it assumed to be the gradient of a potential. We
construct a numerical method for the approximate solution of problems in
this class, and we prove its convergence to a Young measure solution of the
system.
Certain Feynman type integrals involving generalized k-Mittag-Leffler function and general class of polynomials
Authors: Agarwal Praveen , Chand Mehar , Rani Sugandh , Rassias Themistocles
Published: December 2019

In the present paper, certain Feynman type integrals involving the
generalized k-Mittag-Leffler function and the general class of polynomials are
established and further extended these results involving Laguerre
polynomials. On account of the most general nature of the functions
involved therein, our main findings are capable of yielding a large number of
new, interesting, and useful integrals, expansion formulas involving the
generalized k-Mittag-Leffler function, and the Laguerre polynomials as their
special cases.
On cubic Thue equations and the indices of algebraic integers in cubic fields
Authors: Bayad Abdelmejid , Seddik Mohammed
Published: December 2019

Let F(x; y) = ax3 + bx2y + cxy2 + dy3 ? Z[x,y] be an irreducible cubic form.
In this paper, we investigate arithmetic properties of the common indices of
algebraic integers in cubic fields. For each integer k such that v2(k)??0
(mod 3) and 2v2(-2b3 - 27a2d + 9abc) = 3v2(b2 - 3ac), we prove that the
cubic Thue equation F(x,y) = k has no solution (x,y) ? Z2. As application,
we construct parametrized families of twisted elliptic curves E : ax3 + bx2
+ cx + d = ey2 without integer points (x,y).
Orthogonal Dirichlet polynomials with constant weight
Authors: Lubinsky Doron
Published: December 2019

Let {?j}? j=1 be a sequence of distinct positive numbers. We analyze the
orthogonal Dirichlet polynomials {?n,T} formed from linear combinations of
{?-it,j}n j=1 , associated with constant (or Legendre) weight on [-T, T].
Thus 1/2T ? T,-T ?n,T (t) ?m,T(t)dt = ?mn. Moreover, we analyze how these
polynomials behave as T varies.