bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving the Innovative Performance of Renewable Energy Enterprises in China: Effects of Subsidy Policy and Intellectual Property Legislation
Authors: Xu Xiaofeng , Chen Xiangyu , Xu Yi , Wang Tao , Zhang Yifan
Published: July 2022

Energy efficiency and emissions reductions are effective initiatives to address climate change and energy security. China has increased government subsidies and intellectual property protection (IPP) intensity to promote technological innovation in the renewable energy sector. This paper selects samples of geothermal, wind, and solar energy companies and examines whether the two initiatives mentioned above can improve company innovation, and assesses their action pathways. The results reveal that: (i) government subsidies can directly facilitate renewable energy enterprises’ innovative performance, and research and development (R&D) input served as a medium; and (ii) the intensity of IPP moderation needed for geothermal and solar enterprises to utilize the government subsidy to enhance innovation. The government should consider the differences of different sub-sectors of renewable energy when increasing subsidies. Better laws and policies are needed to strengthen the protection of intellectual property rights and stimulate innovation in renewable energy enterprises.
Spatial Distribution and Variation Characteristics of Permafrost Temperature in Northeast China
Authors: Shan Wei , Zhang Chengcheng , Guo Ying , Qiu Lisha , Xu Zhichao , Wang Yan
Published: July 2022

Frozen soil is an important environmental factor in cold regions. Warming climate will increase the risk of permafrost thawing, i.e., accelerated carbon release, reduced super-frozen soil water, intensified desertification and destruction of infrastructure. Based on MOD11A2 and MYD11A2 products of MODIS Terra/Aqua, the distribution and change of surface frost number under the influence of normalized difference vegetation index and forest canopy closure in Northeast China from 2003 to 2019 were produced. From 2012 to 2015, the area of the regions where the surface frost number was higher than 0.5 continued to decrease in Northeast China. Taking 2013 as the time turning point, two periods of changes in the distribution of surface frost number in Northeast China were divided, namely, into 2003–2013 and 2014–2014. The spatial distribution of permafrost temperature is simulated by establishing the numerical relationship between the surface frost number and the annual average ground temperature of permafrost. From 2003 to 2019, the area of permafrost changed from 32.77 × 104 to 27.10 × 104 km2. The distribution characteristics show that the area with permafrost temperature below −4 °C accounts for 0.1%, and below −3.0 °C accounts for 3.45%. The permafrost with lower temperature is mainly distributed in the Greater Khingan Mountains, from the northernmost Mohe to the Aershan in the middle of the ridge. The area where the permafrost temperature ranges from −2 to 0 °C is the largest, accounting for 73.81% of the total area. The distribution of permafrost temperatures in the Greater Khingan Mountains is mainly between −1.5 and −3 °C, while that in the Lesser Khingan Mountains is mainly between −2.0 and 0 °C. The altitude is the main factor controlling the permafrost temperature distributed at high latitudes in Northeast China. This work will provide more detailed basic data for regional research on frozen soil and the environment in Northeast China.
Examining the Role of Stakeholder-Oriented Corporate Governance in Achieving Sustainable Development: Evidence from the SME CSR in the Context of China
Authors: Zhang Lin , Zhang Xiaochen , An Jingjing , Zhang Wei , Yao Jingshen
Published: July 2022

Corporate governance (CG) has been experiencing a shift from the antecedent shareholder-oriented system toward the recent more popular stakeholder-oriented system. To better serve the aim of sustainable development, more and more companies have initiated stakeholder-oriented practices. Increasing social responsibility behaviours demonstrate the prioritisation of stakeholders’ interests. Nevertheless, most extant research on stakeholder-oriented CG focuses on MNEs and large listed companies. Limited attention has been paid to the small and medium-sized enterprises (SMEs) sector. This study aims to fill this gap by providing empirical evidence of Chinese SME corporate social responsibility (CSR). We develop and test two hypotheses by using samples of 172 Chinese listed SMEs. Our result is distinct from most of the extant SME CG literature, given that the stakeholder-oriented CSR types have a negative impact on short-term operational profitability and expansion over a fixed period. Additionally, the government subsidy, as one of the most significant national institutions, partially moderates the relationship between stakeholder-oriented CSR and firm performance. The outcomes of this research make both theoretical and managerial contributions to SMEs’ CG systems. In the context of Chinese SME CSR, managerial stakeholder theory is a more pragmatic means to guide firms toward sustainable development than ethical stakeholder theory.
Heat Stress Adaptation within Informal, Low-Income Urban Settlements in Africa
Authors: Laue Franziska , Adegun Olumuyiwa Bayode , Ley Astrid
Published: July 2022

Climate projections indicate that persistent high temperatures and related heat stress will become a common experience in the future, across Africa. It is, therefore, important to understand challenges that might result from increasing extreme heat conditions, and how humans within urban centres can adapt. In this article, we provide a review that considers the experience of poor urban residents with extreme temperatures and adaptation strategies in relation to low-income, informal urban contexts in Africa. Our analysis is carried out across four focus countries: Nigeria, South Africa, Kenya, and Egypt. Only cursory insights exist in the context of informal settlements. We found that heat stress remains an overlooked topic in comparison to other climate change adaptation needs. Evidence shows that adaptation strategies varied and differed in framing, scale, and applied methods across the contexts. Adaptation strategies dominantly examine a broad variety of alternative building measures and, to a lesser degree, greening/nature-based strategies. It is important to highlight heat stress as a cross-cutting, focal topic in urban research in relation to informal settlements and generally broaden the spectrum. It is worthwhile to pay special attention to strategic actions and research designs that foresee win–win and co-beneficial options for local urban communities.
Improve Stock Price Model-Based Stochastic Pantograph Differential Equation
Authors: Eissa Mahmoud A. , Elsayed M.
Published: July 2022

Although the concept of symmetry is widely used in many fields, it is almost not discussed in finance. This concept appears to be relevant in relation, for example, to mathematical models that can predict stock prices to contribute to the decision-making process. This work considers the stock price of European options with a new class of the non-constant delay model. The stochastic pantograph differential equation (SPDE) with a variable delay is provided in order to overcome the weaknesses of using stochastic models with constant delay. The proposed model is constructed to improve the evaluation process and prediction accuracy for stock prices. The feasibility of the proposed model is introduced under relatively weak conditions imposed on its volatility function. Furthermore, the sensitivity of time lag is discussed. The robust stochastic theta Milstein (STM) method is combined with the Monte Carlo simulation to compute asset prices within the proposed model. In addition, we prove that the numerical solution can preserve the non-negativity of the solution of the model. Numerical experiments using real financial data indicate that there is an increasing possibility of prediction accuracy for the proposed model with a variable delay compared to non-linear models with constant delay and the classical Black and Scholes model.
Effect of Zeolite Catalyst on the Pyrolysis Kinetics of Multi-Layered Plastic Food Packaging
Authors: Kremer Irma , Tomić Tihomir , Katančić Zvonimir , Hrnjak-Murgić Zlata , Erceg Matko , Vecchio Ciprioti Stefano , Schneider Daniel Rolph
Published: July 2022

Pyrolysis is gaining more significance as a technology used to produce alternative fuels and chemicals. This study dealt with the catalytic pyrolysis of a realistic waste mixture of multi-layered plastic food packaging. The thermal behavior, kinetic parameters, and kinetic model of multi-layered plastic food packaging pyrolysis were determined to show its potential for process scale-up. In particular, we aimed to evaluate the effect of a ZSM-5 zeolite catalyst, modified with iron(III) oxide. The pyrolysis process on this decagonal structure was investigated using thermogravimetric analysis under nitrogen flow at four heating rates ranging between 40 and 600 °C. The kinetic study was conducted using the model-free isoconversional Friedman method as well as advanced statistical analysis to determine the reaction mechanism of the process. The thermal decomposition occurred in the range of 350–510 °C, with a mass loss greater than 90%. The kinetic study revealed a complex pyrolysis process, which consisted of three decomposition stages, diffusion, and Avrami-Erofeev reaction types. The activation energy values determined by the Friedman method rose with the degree of conversion, from 127 kJ mol−1 at 0.01 to 219 kJ mol−1 at 0.95. The doping of the catalyst lowered the activation energy of the reaction by 44% and 8% in the first and second stages, respectively, and increased the acidity of the zeolites, thus enhancing the reactivity on the surface of the catalysts. Lower activation energy meant less energy was required to heat the pyrolysis reactor since the onset temperature of sample decomposition was reduced.
On Ulam Stability of Functional Equations in 2-Normed Spaces—A Survey II
Authors: El-hady El-sayed , Brzdęk Janusz
Published: July 2022

Ulam stability is motivated by the following issue: how much an approximate solution of an equation differs from the exact solutions to the equation. It is connected to some other areas of investigation, e.g., optimization, approximation theory and shadowing. In this paper, we present and discuss the published results on such stability for functional equations in the classes of function-taking values in 2-normed spaces. In particular, we point to several pitfalls they contain and provide possible simple improvements to some of them. Thus we show that the easily noticeable symmetry between them and the analogous results proven for normed spaces is, in fact, mainly apparent. Our article complements the earlier similar review published in Symmetry (13(11), 2200) because it concerns the outcomes that have not been discussed in this earlier publication.
Hankel Determinants and Coefficient Estimates for Starlike Functions Related to Symmetric Booth Lemniscate
Authors: Raza Mohsan , Riaz Amina , Xin Qin , Malik Sarfraz Nawaz
Published: July 2022

In this paper, we find Hankel determinants and coefficient bounds for a subclass of starlike functions related to Booth lemniscate. In particular, we obtain the first four sharp coefficient bounds, Hankel determinants of order two and three, and Zalcman conjecture for this class of functions.
Performance-Based Seismic Design of Hybrid Isolation Systems with Gap-Tunable BRBs for Bearing-Supported Bridges
Authors: Liu Qunfeng , Guo Zhaoyang , Zhu Shimin , Wang Chang , Ren Xiang , Wu Xing
Published: July 2022

This study proposes a class of hybrid isolation systems constructed by combining Buckling Restrained Braces (BRBs) with Rubber Bearings (RBs) or Lead Rubber Bearings (LRBs) for mitigating the seismic responses in bearing-supported bridges under strong earthquakes. Firstly, two different hybrid isolation systems (RB–BRB and LRB–BRB) were preliminarily designed based on the energy-conservation concept in the case of a bridge with Y-shaped piers, which can meet all the energy demands at different seismic hazard levels. Further, seismic evaluations were conducted on the bridges with the LRB, RB–BRB, and LRB–BRB isolation systems based on the nonlinear time history analyses. The proposed hybrid isolation systems show a two-phase energy dissipation behavior, which facilitates the systems to reduce the seismic responses remarkably under different earthquake scenarios and achieve most of the performance objectives corresponding to the code-specified hazard levels. Finally, based on fragility analyses, the effects of the gap spacing and the stiffness ratio of the BRB to the pier were investigated with respect to the failure probability in the case of a bridge with LRB–BRB. It has been validated that the seismic performances of this study’s bridge can be improved considerably with the optimized gap spacing and BRB stiffness.
The Prevalence of Shoulder Disorders among Professional Bullfighters: A Cross-Sectional Ultrasonography Study
Authors: Navas-Mosqueda Álvaro , Valera-Calero Juan Antonio , Varol Umut , Klich Sebastian , Navarro-Santana Marcos José , Fernández-de-las-Peñas César , Ríos-León Marta , Belón-Pérez Pedro , Cimadevilla-Fernández-Pola Eduardo , Hervás-Pérez Juan Pablo , Arias-Buría José Luis
Published: July 2022

We aimed to investigate clinical and ultrasound signs of shoulder overuse injuries in professional bullfighters; side-to-side differences (dominant vs. non-dominant); and to determine potential differences according to bullfighters’ categories. An observational cross-sectional study was conducted. Thirty professional and active bullfighters were assessed. A bilateral ultrasound assessment of the subacromial bursa, long biceps head tendon (LHBT), and rotator cuff was performed to determine the presence of bursitis, subluxation, partial or total tendon rupture, tenosynovitis, or calcification. Supraspinatus tendon thickness was measured. Finally, a battery of clinical orthopedic tests (Yergason, Jobe, infraspinatus, Gerber, and bursa tests) were also performed. Most identified ultrasound findings were located in the dominant side, being the presence of bursitis (n = 9; 30%), LHBT tenosynovitis (n = 8; 26.7%), and subscapularis tendon calcification (n = 5; 16.7%) the most prevalent. No side-to-side or between-categories differences were found for supraspinatus tendon thickness (all, p > 0.05). The most frequent positive signs were the infraspinatus test (40.0%), Gerber lift-off test (33.3%), and bursitis, Jobe, and Yergason tests (all, 26.7%). Ultrasound signs were commonly found at LHBT, subacromial bursa, and rotator cuff in professional bullfighters without difference between categories and sides. No side-to-side or between-categories differences were found. Positive clinical test signs suggestive of bursitis, LHBT, and rotator cuff tendinopathy were frequently observed.
Prenatal Exposure to Locally Emitted Air Pollutants Is Associated with Birth Weight: An Administrative Cohort Study from Southern Sweden
Authors: Balidemaj Festina , Flanagan Erin , Malmqvist Ebba , Rittner Ralf , Källén Karin , Åström Daniel Oudin , Oudin Anna
Published: July 2022

While prenatal exposure to ambient air pollution has been shown to be associated with reduced birth weight, there is substantial heterogeneity across studies, and few epidemiological studies have utilized source-specific exposure data. The aim of the present study was, therefore, to investigate the associations between local, source-specific exposure to fine particulate matter (PM2.5) during pregnancy and birth weight. An administrative cohort comprising 40,245 singleton births from 2000 to 2009 in Scania, Sweden, was combined with data on relevant covariates. Investigated sources of PM2.5 included all local sources together as well as tailpipe exhaust, vehicle wear-and-tear, and small-scale residential heating separately. The relationships between these exposures, represented as interquartile range (IQR) increases, and birth weight (continuous) and low birth weight (LBW; <2500 g) were analyzed in crude and adjusted models. Each local PM2.5 source investigated was associated with reduced birth weight; average decreases varied by source (12–34 g). Only small-scale residential heating was clearly associated with LBW (adjusted odds ratio: 1.14 (95% confidence interval: 1.04–1.26) per IQR increase). These results add to existing evidence that prenatal exposure to ambient air pollution disrupts fetal growth and suggest that PM2.5 from both vehicles and small-scale residential heating may reduce birth weight.
Mycotoxins in Tea ((Camellia sinensis (L.) Kuntze)): Contamination and Dietary Exposure Profiling in the Chinese Population
Authors: Zhou Haiyan , Yan Zheng , Wu Aibo , Liu Na
Published: July 2022

Tea is popular worldwide with multiple health benefits. It may be contaminated by the accidental introduction of toxigenic fungi during production and storage. The present study focuses on potential mycotoxin contamination in tea and the probable dietary exposure assessments associated with consumption. The contamination levels for 16 mycotoxins in 352 Chinese tea samples were determined by ultra-performance liquid chromatography–tandem mass spectrometry. Average concentrations of almost all mycotoxins in tea samples were below the established regulations, except for ochratoxin A in the dark tea samples. A risk assessment was performed for the worst-case scenarios by point evaluation and Monte Carlo assessment model using the obtained mycotoxin levels and the available green, oolong, black, and dark tea consumption data from cities in China. Additionally, we discuss dietary risk through tea consumption as beverages and dietary supplements. In conclusion, there is no dietary risk of exposure to mycotoxins through tea consumption in the Chinese population.
Trajectory Analysis and Optimization of Hesperides Mission
Authors: Mengali Giovanni , Quarta Alessandro A.
Published: July 2022

A challenging problem from a technological viewpoint is to send a spacecraft at a distance of about 600 au from the Sun, comparable with that of the Sun’s gravitational focus (that is, the general relativistic focusing of light rays, whose minimum solar distance is obtained when the light rays are assumed to graze the Sun’s surface), and reach it in a time interval on the order of a human working lifetime. A suitably oriented telescope at that distance would be theoretically able to observe exoplanets tens of light years far away and possibly to discover new life forms. The transfer trajectory of this mission is rather complex and requires a close selection of a suitable propulsion system, which must be able to provide the probe with the necessary energy to cruise at a velocity greater than 10 au/year. An effective outline of the these concepts is given by the Hesperides mission, originally proposed by Matloff in 2014. An interesting aspect of this mission proposal is the combination of a nuclear electric propulsion system and a classical solar sail that are jointly exploited to reach the necessary solar system escape velocity. However, the trajectory analysis reported by Matloff is very simplified and is essentially concentrated on a rough estimate of the time required by the spacecraft to reach a distance of 600au. Starting from the Hesperides baseline mission proposal, including the vehicle mass distribution, the aim of this work is to give a detailed mission analysis in an optimal framework. In particular, the spacecraft minimum time trajectory is calculated with indirect methods and a parametric analysis is made to highlight the impact of the main design parameters on the total flight time. The simulations show a substantial reduction of the mission time when compared with the original study.
Monte Carlo Models of Comet Dust Tails Observed from the Ground
Authors: Moreno Fernando
Published: July 2022

Dust particles leaving the comet nucleus surface are entrained by the gas within the first few nuclear radius distances and are subjected to a complex hydrodynamical environment. From distances of about 20 nuclear radii outwards, the particles decouple from the accelerating gas and are mainly affected by solar gravity and radiation pressure for small-sized nuclei. Their motion is then a function of their so-called β parameter, which is the ratio of the radiation pressure force to gravity force, and their velocity when the gas drag vanishes. At a given observation time, the position of those particles projected on the sky plane form the coma, tail and trail structures that can be observed from ground-based or space-borne instrumentation. Monte Carlo models, based on the computer simulation of the Keplerian trajectories of a large set of dust particles, provide the best possible approach to extract the dust environment parameters from the observed scattered solar light or thermal emission. In this paper, we describe the Monte Carlo code along with some successful applications of such technique to a number of targets.
The Effect of Age on the Grouping of Open Clusters: II—Are There Old Binary Clusters?
Authors: Casado Juan
Published: July 2022

In the present study, we continue testing the Primordial Group hypothesis (Casado 2022), which postulates that only sufficiently young open clusters can be binary or multiple, and old clusters are essentially single. To this end, we revisit all the remaining binary cluster candidates in the Galaxy having at least one cluster older than 100 Myr through Gaia data and careful revision of the literature. We found no convincing case for an old binary system among the 120 pairs/groups revised. Most of the pairs are optical pairs or flyby encounters. However, we found three dubious pairs that could falsify the title hypothesis upon further research. We also found two possible primordial pairs older than expected. Our results confirm that the vast majority of binary/multiple OCs in the Galaxy, if not all, are of primordial origin and are not stable for a long time. This finding is in line with similar studies of the Magellanic Clouds and theoretical N-body simulations in the Galaxy. The pairs of OCs in these groups are generally not binary systems since they are not gravitationally bound. We also point out some inconsistencies in previous works and databases, such as false open clusters and duplicities.
Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription
Authors: Zhao Ningning , Wang Fan , Kong Zhengjie , Shang Yingli
Published: July 2022

Pseudorabies virus (PRV) has evolved various strategies to escape host antiviral immune responses. However, it remains unclear whether and how PRV-encoded proteins modulate the RIG-I-like receptor (RLR)-mediated signals for immune evasion. Here, we show that the PRV tegument protein UL13 functions as an antagonist of RLR-mediated antiviral responses via suppression of the transcription of RIG-I and MDA5, but not LGP2. UL13 overexpression significantly inhibits both the mRNA and protein levels of RIG-I and MDA5, along with RIG-I- or MDA5-mediated antiviral immune responses, whereas overexpression of RIG-I or MDA5 counteracts such UL13-induced suppression. Mechanistically, UL13 suppresses the expression of RIG-I and MDA5 by inhibiting activation of the transcription factor NF-κB. Consequently, overexpression of p65 promotes the activation of RIG-I and MDA5 promoters. Moreover, deletion of the p65-binding sites in the promoters of RIG-I or MDA5 abolishes the suppression role of UL13. As a result, mutant PRV lacking UL13 elicits stronger host antiviral immune responses than PRV-WT. Hence, our results provide a novel functional role of UL13-induced suppression of host antiviral immunity through modulating receptors’ transcription.
On the Parametrization of Epidemiologic Models—Lessons from Modelling COVID-19 Epidemic
Authors: Kheifetz Yuri , Kirsten Holger , Scholz Markus
Published: July 2022

Numerous prediction models of SARS-CoV-2 pandemic were proposed in the past. Unknown parameters of these models are often estimated based on observational data. However, lag in case-reporting, changing testing policy or incompleteness of data lead to biased estimates. Moreover, parametrization is time-dependent due to changing age-structures, emerging virus variants, non-pharmaceutical interventions, and vaccination programs. To cover these aspects, we propose a principled approach to parametrize a SIR-type epidemiologic model by embedding it as a hidden layer into an input-output non-linear dynamical system (IO-NLDS). Observable data are coupled to hidden states of the model by appropriate data models considering possible biases of the data. This includes data issues such as known delays or biases in reporting. We estimate model parameters including their time-dependence by a Bayesian knowledge synthesis process considering parameter ranges derived from external studies as prior information. We applied this approach on a specific SIR-type model and data of Germany and Saxony demonstrating good prediction performances. Our approach can estimate and compare the relative effectiveness of non-pharmaceutical interventions and provide scenarios of the future course of the epidemic under specified conditions. It can be translated to other data sets, i.e., other countries and other SIR-type models.
Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL
Authors: Albalawi Yasmeen A. , Narasipura Srinivas D. , Al-Harthi Lena
Published: July 2022

HIV infection mediates the apoptosis of lymphocytes, the mechanism of which is multifaceted. Here, we evaluated the role of Wnt/β-catenin signaling in HIV-associated T cell apoptosis, as Wnt/β-catenin regulates the transcriptional activity of genes impacting apoptosis. We specifically investigated the role of the Wnt/β-catenin pathway in the HIV-associated apoptosis of CD4+ T cells and CD4dimCD8bright T cells, a population that is infected by HIV. We found that the induction of β-catenin, via a 6-bromoindirubin-3-oxime (BIO), significantly rescued HIV-infected CD4+ and CD4dimCD8bright T cells from apoptosis by >40–50%. Further, a small-molecule inhibitor of the Wnt/β-catenin pathway (PNU-74654) reversed BIO-mediated protection from HIV-associated apoptosis. BIO also induced Bcl-xL, an anti-apoptotic protein, and a target gene of Wnt/β-catenin, in CD4+ and CD4dimCD8bright T cells by approximately 3-fold. Inhibiting Bcl-xL by WEHI-539 abrogated β-catenin-mediated apoptotic protection in infected CD4+ and CD4dimCD8bright T cells. Collectively, these findings demonstrate that engaging Wnt/β-catenin signaling in HIV-infected T cells protects them from HIV-associated apoptosis by inducing Bcl-xL.
Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome
Authors: Otsuka Kunihiro , Sato Mami , Tsunematsu Takaaki , Ishimaru Naozumi
Published: July 2022

Sjögren’s syndrome (SS) is an autoimmune disease especially targeting exocrine glands, such as the salivary and lacrimal glands. A radical therapy for SS based on its etiology has not been established because of the complex pathogenesis of the disease. Several studies have demonstrated a relationship between virus infection and SS pathogenesis. In particular, infection with the Epstein-Barr (EB) virus among others is a potent factor associated with the onset or development of SS. Specifically, virus infection in the target organs of SS triggers or promotes autoreactive responses involving the process of autoantigen formation, antigen-presenting function, or T-cell response. Our review of recent research highlights the crucial roles of virus infection in the pathogenesis of SS and discusses the critical association between virus infection and the etiology of autoimmunity in SS.
Immunity after COVID-19 Recovery and Vaccination: Similarities and Differences
Authors: Kamińska Dorota , Dęborska-Materkowska Dominika , Kościelska-Kasprzak Katarzyna , Mazanowska Oktawia , Remiorz Agata , Poznański Paweł , Durlik Magdalena , Krajewska Magdalena
Published: July 2022

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with a robust immune response. The development of systemic inflammation leads to a hyperinflammatory state due to cytokine release syndrome during severe COVID-19. The emergence of many new SARS-CoV-2 variants across the world deteriorates the protective antiviral immunity induced after infection or vaccination. The innate immune response to SARS-CoV-2 is crucial for determining the fate of COVID-19 symptomatology. T cell-mediated immunity is the main factor of the antiviral immune response; moreover, SARS-CoV-2 infection initiates a rapid B-cell response. In this paper, we present the current state of knowledge on immunity after COVID-19 infection and vaccination. We discuss the mechanisms of immune response to various types of vaccines (nucleoside-modified, adenovirus-vectored, inactivated virus vaccines and recombinant protein adjuvanted formulations). This includes specific aspects of vaccination in selected patient populations with altered immune activity (the elderly, children, pregnant women, solid organ transplant recipients, patients with systemic rheumatic diseases or malignancies). We also present diagnostic and research tools available to study the anti-SARS-CoV-2 cellular and humoral immune responses.
Oral Administration with Recombinant Attenuated Regulated Delayed Lysis Salmonella Vaccines Protecting against Staphylococcus aureus Kidney Abscess Formation
Authors: Liang Yanchen , Zhang Haochi , Pan Na , Liu Yang , Sheng Shouxin , Li Haotian , Bao Xuemei , Wang Xiao
Published: July 2022

Abscess formation is one of the main symptoms of Staphylococcus aureus infection. It is very important to inhibit abscess formation for preventing S. aureus persistent infection. To find a feasible solution, the live oral vaccines delivering S. aureus antigens, rEsxAB and rHlam, were constructed, which were based on the attenuated regulated delayed lysis Salmonella enterica subspecies Serovar Typhimurium strain χ11802, and the inhibiting effect on abscess formation was evaluated in mice kidneys. As the results showed, after oral administration, humoral immunity was induced via the mucosal route as the antigen-specific IgG in the serum and IgA in the intestinal mucus both showed significant increases. Meanwhile, the production of IFN-γ and IL-17 in the kidney tissue suggested that Th1/Th17-biased cellular immunity played a role in varying degrees. After challenged intravenously (i.v.) with S. aureus USA300, the χ11802(pYA3681−esxAB)-vaccinated group showed obvious inhibition in kidney abscess formation among the vaccinated group, as the kidney abscess incidence rate and the staphylococcal load significantly reduced, and the kidney pathological injury was improved significantly. In conclusion, this study provided experimental data and showed great potential for live oral vaccine development with the attenuated regulated delayed lysis Salmonella Typhimurium strains against S. aureus infection.
Determinants of COVID-19 Vaccine Uptake and Acceptability in the Horn of Africa: Evidence from Somaliland
Authors: Sulub Saed A. , Mohamed Mubarak A.
Published: July 2022

Various COVID-19 vaccines have been developed in an unprecedented time and were rolled out across the world to save lives during the COVID-19 pandemic. Yet statistics show that COVID-19 uptake and acceptance in the Horn of Africa have been very low. To examine factors associated with COVID-19 vaccine uptake and acceptance in Somaliland, we carried out a cross-sectional study using a structured questionnaire both in offline and online modes. The study population was adults from the age of 18 years and above. Of the 704 respondents who participated in the survey, only 37% took the vaccine. Surprisingly, about 65% of those who have not taken the vaccine were unwilling to get vaccinated. Using a binomial logistic regression, we find that older people, the more educated and those who are employed are more likely to take the vaccine. Our results also show that the perceived threat of the virus and the perceived safety of the vaccine significantly increase vaccine uptake and acceptance. Results of this study will help the government and other concerned parties shape policies that can boost vaccine uptake and acceptance.
The Role of Citrus Groves in Rainfall-Triggered Landslide Hazards in Uwajima, Japan
Authors: Lusiana Novia , Shinohara Yoshinori
Published: July 2022

Landslides often cause deaths and severe economic losses. In general, forests play an important role in reducing landslide probability because of the stabilizing effect of the tree roots. Although fruit groves consist of trees, which are similar to forests, practical land management, such as the frequent trampling of fields by laborers and compression of the terrain, may cause such land to become prone to landslides compared with forests. Fruit groves are widely distributed in hilly regions, but few studies have examined their role in landslide initiation. This study aims at filling this gap evaluating the predisposing and triggering conditions for rainfall-triggering landslides in part of Uwajima City, Japan. A large number of landslides occurred due to a heavy rainfall event in July 2018, where citrus groves occupied about 50% of the study area. In this study, we combined geodata with a regression model to assess the landslide hazard of fruit groves in hilly regions. We developed maps for five conditioning factors: slope gradient, slope aspect, normalized difference vegetation index (NDVI), land use, and geology. Based on these five maps and a landslide inventory map, we found that the landslide area density in citrus groves was larger than in forests for the categories of slope gradient, slope aspect, NDVI, and geology. Ten logistic regression models along with different rainfall indices (i.e., 1-h, 3-h, 12-h, 24-h maximum rainfall and total rainfall) and different land use (forests or citrus groves) in addition to the other four conditioning factors were produced. The result revealed that “citrus grove” was a significant factor with a positive coefficient for all models, whereas “forest” was a negative coefficient. These results suggest that citrus groves have a higher probability of landslide initiation than forests in this study area. Similar studies targeting different sites with various types of fruit groves and several rainfall events are crucial to generalize the analysis of landslide hazard in fruit groves.
Modification of Natural Peat for Removal of Copper Ions from Aqueous Solutions
Authors: Shvartseva Olga , Skripkina Tatiana , Gaskova Olga , Podgorbunskikh Ekaterina
Published: July 2022

This study aimed at estimating peat adsorption properties for copper ion removal from aqueous solutions during peat modification. Two peat modifications have been studied using batch tests and quantitatively reproduced with instrumental analysis by using spectrometric, potentiometric, and thermodynamic modeling methods. The first variation—mechanical activation—was carried out in a planetary mill; for the second one—mechanochemical activation—dry sodium percarbonate (Na2CO3·1.5H2O2) was added. The adsorption of copper ions was studied in the concentration range from 10–150 mg/L with an interaction time from 0.25–12 h. Both modifications led to significant changes in the interaction energy in the adsorption layer; thus, the acceptor properties of macromolecules were enhanced from natural peat to mechanically activated peat and mechanochemically activated peat. FTIR spectra, specific surface area characteristics, and sorption experiments show the predominantly chemical nature of copper sorption. Maximum adsorption capacity was determined to be 24.1, 42.1, and 16.0 mg/g for natural peat, mechanically activated peat, and mechanochemically activated peat, respectively. The example of peat mechanochemically oxidized with Na2CO3·1.5H2O2 shows that the improvement in the physicochemical properties (CBET and specific surface area) plays a smaller role in the sorption capacity in relation to copper ions than the presence of phenolic and carboxyl groups, the content of which decreases during oxidation.
A Potential Approach of Reporting Risk to Baseflow from Increased Groundwater Extraction in the Murray-Darling Basin, South-Eastern Australia
Authors: Walker Glen
Published: July 2022

An approach of reporting long-term trends in groundwater extraction and baseflow impacts in the Murray-Darling Basin (MDB) in south-eastern Australia was developed and tested. The principal aim of the framework was to provide early warning of any potential adverse impacts from groundwater extraction on environmental releases of surface water for baseflow, support adaptive management of these impacts, and highlight those areas which may benefit from conjunctive water management. The analysis showed that there is no current decadal trend in the annual aggregate groundwater extraction volumes or stream impact across the non-Victorian MDB, with much of the interannual variability being related to rainfall. Despite this, increasing volumes of environmental releases of water for baseflows in some river valleys are being required to replace the stream depletion caused by historical patterns of groundwater extraction established before 2003. Two valleys were identified for which there may be insufficient surface water storage to release water to substitute stream losses to groundwater and still support ecosystems during dry periods. The increasing trend in extraction since 2003 in one of the units has significantly increased the risk in that valley. The reporting framework was shown to be effective for alluvial groundwater systems connected to regulated rivers.
Optimal Water Resources Allocation in the Yinma River Basin in Jilin Province, China, Using Fuzzy Programming
Authors: Li Pengyu , Yang Hao , He Wei , Yang Luze , Hao Ning , Sun Peixuan , Li Yu
Published: July 2022

Being one of the most important sources of water in the Jilin Province in China, the Yinma River Basin (YRB) is facing problems of water scarcity in low economic areas and low utilization in richer areas mainly caused by the irrational allocation of water, excessive pursuit of economic benefits, and neglect of environmental problems. Restricting watershed development involves potential decision-making risks. Some scholars have used the interval two-stage stochastic planning method to adjust water resource allocation in the Drinking Horse River Basin, but the method uses historical statistics for projection and does not take into account the ambiguity and uncertainty in real planning situations. Therefore, this study addresses the problems prevalent in the allocation of water resources in the YRB through optimization using stochastic programming methods, interval and two-stage, and introduces the fuzzy mathematical programming method, with the aim of coordinating the water balance of various water-consuming sectors in the YRB, so as to reconfigure the water allocation. The goal is to solve the existing problems of irrational water allocation, reduce system risks posed by excessive economic development, mitigate water shortages in the water-consuming sectors, and alleviate potential decision-making risks and vague uncertainties associated with the allocation of water resources. Additionally, optimization of the pollution-holding capacity improvement project was carried out. The interval fuzzy two-stage model simulation developed in this study shows that the distribution of water across the different administrative regions can be reduced by up to 30% compared with the original model, effectively reducing the problem of water wastage. Post-optimization, the impact of water shortage in the water resources allocation scheme is alleviated to a significant degree, and there is no water shortage in some areas. At the same time, the eco-environmental sector has gradually taken the leading role in the distribution of water reuse among the different water-consuming sectors. The pollution-holding capacity has been enhanced, and the discharge and river entry chemical oxygen demand (COD) and ammonia nitrogen, two typical pollutants, have been reduced. The membership interval in the interval fuzzy two-stage model reflects the relationship between the possible level of the target value and the risk level. This study provides a guideline for decision makers for balancing the relationship between benefits and risks and proposes a planning scheme that is more conducive to the development of the river basin.
Assessment of Ammonium–N and Nitrate–N Contamination of Shallow Groundwater in a Complex Agricultural Region, Central Western Taiwan
Authors: Chen Shih-Kai , Lee Yuan-Yu , Liao Tzu-Ling
Published: July 2022

The characteristics of nitrogen contamination of shallow groundwater were evaluated through current status analysis and trend detection of ammonium–N and nitrate–N concentrations under various cropping patterns to assess the effectiveness of rational fertilization in the Choushui River alluvial fan, central Western Taiwan. The influence of cropping patterns on both ammonium–N and nitrate–N contamination associated with redox conditions/dissolved oxygen (DO) in shallow groundwater was also discussed in this study. The analysis revealed that shallow groundwater beneath double rice cropping and rotational cropping regions is still characterized by high ammonium–N concentration despite rational fertilization promotion. However, very few monitoring wells showed an upward trend of ammonium–N/nitrate–N concentrations, indicating that shallow groundwater is not further deteriorated by nitrogen pollution in most parts of the study area. Therefore, the remediation of nitrogen contaminated groundwater will be a long-term process and more effort must be invested. Moreover, the strict redox conditions defined by a single DO threshold value may not account for groundwater nitrogen pollution in the study area. It is difficult to determine the redox conditions and predominant nitrogen pollution patterns of shallow groundwater purely from cropping patterns. Instead, contamination may have resulted from an integrated process governed by several other factors. Tracing the potential sources of nitrogen pollution and establishing a more integral monitoring network should be implemented to formulate a more comprehensive nitrogen pollution control strategy in this area.
Long-Term Study of Monitoring History and Change Trends in Surface Water Quality in China
Authors: Zhang Fengying , Lin Lanyu , Li Wenpan , Fang Dekun , Lv Zhuo , Li Mingsheng , Ma Guangwen , Wang Yeyao , Wang Li , He Lihuan
Published: July 2022

To investigate the monitoring history and long-term change trends in surface water quality in China since the reform and opening up, the history of surface water environment monitoring is summarized, including monitoring scope, monitoring methods, and technical requirements. Temporal and spatial patterns of surface water quality in China were analyzed based on the monitoring results. In the past 40 years, the monitoring targets for surface water quality have been continuously improved, the frequency of monitoring has become more science-based, and the monitoring indicators are now comprehensive. Overall, the temporal change trend in surface water quality has followed a “fluctuating changes stage—rapid deterioration stage—fluctuations stalemate stage—rapid improvement stage” pattern. However, the current regional surface water quality is still in a polluted status, and there is a gap between surface water quality status and the goal of building a well-off society. At present, China’s surface water pollution is prone to high numbers of incidents and the treatment of surface water pollution has entered a crucial stage. The potential for the continuous reduction of major pollutant discharges has become more challenging, and the marginal cost for pollution control has increased. It is very difficult to comprehensively solve the outstanding water environment problems. In addition to strengthening the existing work on surface water quality control, it is also necessary to strengthen the work of risk identification, early warning, and regulation implementation of the surface water environment. During the 14th year plan period (2021–2025), the overall planning on water resources, water ecology, and water quality will be implemented, and beautiful rivers and lakes will be created.
Field Application of Spent Lime Water Treatment Residual for the Removal of Phosphorus and other Pollutants in Urban Stormwater Runoff
Authors: Kuster Anthony C. , Pilgrim Keith M. , Kuster Anootnara T. , Huser Brian J.
Published: July 2022

The threat of anthropogenic eutrophication and harmful algal blooms in lakes requires the development of innovative stormwater best management practices (BMPs) to reduce the external loading of phosphorus (P). This paper presents the findings of a 5-year study of a full-scale P removal structure constructed in Minnesota, USA with spent lime drinking water treatment residual (DWTR), a by-product of water softening at a local water treatment plant. Influent and effluent water samples were collected by auto-samplers during 43 storm events during the growing season. Samples were analyzed for P constituents, heavy metals, total suspended solids (TSS), and pH. Toxicity of the effluent was assessed using Ceriodaphnia dubia. Flow-weighted removal effectiveness was calculated for each storm event. Overall, the spent lime DWTR reduced total P loading by 70.9%, dissolved reactive P by 78.5%, dissolved P by 74.7%, and TSS by 58.5%. A significant reduction in heavy metals was also observed. Toxicity tests indicated the aquatic toxicity of the effluent treated with spent lime DWTR was not different from untreated stormwater. This study provided long-term real-world data that demonstrated that a full-scale P removal structure with spent lime DWTR significantly reduced P and other pollutants in stormwater discharging to an urban lake. Therefore, spent lime DWTR, which is currently treated as a waste product, is a promising filter material for stormwater treatment.
Safety of antithrombotic therapy in elderly patients: analysis of the Russian Pharmacovigilance Database
Authors:   Peoples’ Friendship University of Russia (RUDN University), Moscow, Zatolochina Karina E. , Zyryanov Sergey Kensarinovitch ,   Peoples’ Friendship University of Russia (RUDN University), State Budgetary Institution of Healthcare «City Clinical Hospital No. 24 of the Moscow City Health Department»,  Moscow, Ushkalova Elena A. ,   State Budgetary Institution of Healthcare «City Clinical Hospital No. 24 of the Moscow City Health Department»
Published: July 2022

The article discusses the safety issues of the use of antithrombotic drugs in elderly patients. We analyzed ADR reports submitted to the Russian Spontaneous Report Database from January 2008 to June 2018. The recommendations by the European Medical Agency was used to identify potential statistical signals of disproportionate reporting. The indicators ROR (Reporting Odds Ratio), PRR (Proportional Reporting Ratio) were calculated. We identified 314 statistical safety signals for the use of antithrombotic drugs in elderly patients. Most of the statistical signals were identified for known, predicted ADRs. About half of the signals (44,6 %) concerned hemorrhagic ADRs.