bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of an enthalpy‐based frozen soil model and its validation in a cold region in China
Authors: Bao Huiyi , Koike Toshio , Yang Kun , Wang Lei , Shrestha Maheswor , Lawford Peter
Published: April 2016

An enthalpy‐based frozen soil model was developed for the simulation of water and energy transfer in cold regions. To simulate the soil freezing/thawing processes stably and efficiently, a three‐step algorithm was applied to solve the nonlinear governing equations: (1) a thermal diffusion equation was implemented to simulate the heat conduction between soil layers; (2) a freezing/thawing scheme used a critical temperature criterion to judge the phase status and introduced enthalpy and total water mass into freezing depression equation to represent ice formation/melt and corresponding latent heat release/absorption; and (3) a water flow scheme was employed to describe the liquid movement within frozen soil. In addition, a parameterization set of hydraulic and thermal properties was updated by considering the frozen soil effect. The performance of the frozen soil model was validated at point scale in a typical mountainous permafrost basin of China. An ice profile initialization method is proposed for permafrost modeling. Results show that the model can achieve a convergent solution at a time step of hourly and a surface layer thickness of centimeters that are typically used in current land surface models. The simulated profiles of soil temperature, liquid water content, ice content and thawing front depth are in good agreement with the observations and the characteristics of permafrost. The model is capable of continuously reproducing the diurnal and seasonal freeze‐thaw cycle and simulating frozen soil hydrological processes.
Consideration of coastal carbonate chemistry in understanding biological calcification
Authors: Fassbender Andrea J. , Sabine Christopher L. , Feifel Kirsten M.
Published: April 2016

Correlations between aragonite saturation state (ΩAr) and calcification have been identified in many laboratory manipulation experiments aiming to assess biological responses to ocean acidification (OA). These relationships have been used with projections of ΩAr under continued OA to evaluate potential impacts on marine calcifiers. Recent work suggests, however, that calcification in some species may be controlled by the ratio of bicarbonate to hydrogen ion, or the substrate‐to‐inhibitor ratio (SIR), rather than ΩAr. SIR and ΩAr are not always positively correlated in the natural environment, which means that ΩAr can be a poor indicator of the calcifying environment when ΩAr‐>1. Highly variable carbonate chemistry in the coastal zone challenges our ability to monitor fluctuations in ΩAr, SIR, and the ΩAr‐SIR relationship making it difficult to assess biological OA exposures and vulnerability. Careful consideration of natural variability throughout ocean environments is required to accurately determine the influence of OA on biological calcification.
First in situ evidence of electron pitch angle scattering due to magnetic field line curvature in the Ion diffusion region
Authors: Zhang Y. C. , Shen C. , Marchaudon A. , Rong Z. J. , Lavraud B. , Fazakerley A. , Yao Z. , Mihaljcic B. , Ji Y. , Ma Y. H. , Liu Z. X.
Published: April 2016

Theory predicts that the first adiabatic invariant of a charged particle may be violated in a region of highly curved field lines, leading to significant pitch angle scattering for particles whose gyroradius are comparable to the radius of the magnetic field line curvature. This scattering generates more isotropic particle distribution functions, with important impacts on the presence or absence of plasma instabilities. Using magnetic curvature analysis based on multipoint Cluster spacecraft observations, we present the first investigation of magnetic curvature in the vicinity of an ion diffusion region where reconnected field lines are highly curved. Electrons at energies > 8 keV show a clear pitch angle ordering between bidirectional and trapped distribution in surrounding regions, while we show that in the more central part of the ion diffusion region electrons above such energies become isotropic. By contrast, colder electrons (~1 keV) retain their bidirectional character throughout the diffusion regions. The calculated adiabatic parameter K2 for these electrons is in agreement with theory. This study provides the first observational evidence for particle pitch angle scattering due to magnetic field lines with well characterized curvature in a space plasma.
Reconstruction of the electron diffusion region
Authors: Sonnerup B. U. Ö. , Hasegawa H. , Denton R. E. , Nakamura T. K. M.
Published: April 2016

We discuss mathematical tools for the reconstruction of two‐dimensional, time‐independent magnetic field and flow in the electron diffusion region, at a site of antiparallel magnetic reconnection. The basic assumptions are that the ions are stationary and have constant density. The width of the reconnection layer is of the order of the electron gyroradius or the electron inertial length. Our model includes the axial electron pressure term in Ohm's law developed by M. Hesse and coworkers. We demonstrate the feasibility of doing reconstruction of electron magnetohydrodynamic (EMHD) structures for a simplified system with zero electron inertia. The code is benchmarked using an exact solution that has antiparallel unidirectional magnetic fields, plus out‐of‐plane quadrupolar Hall fields, as well as the expected slow electron inflow and rapid exit jets. The inertialess reconstruction is then applied to synthetic data from a 2‐D, particle‐in‐cell, simulation of antiparallel reconnection. We find that the inertialess reconstruction of its electron diffusion region works reasonably well only when the spacecraft path passes close to the center of the reconnection site where the magnetic field is zero and the electron flow has a stagnation point. When the path is located farther away, the effects of electron inertia, and probably also deviations from the Hesse formula, cause the quality of the reconstruction to deteriorate. Electron inertia is included in the theoretical development presented here but requires a more complicated numerical reconstruction code. The development and testing of such a code is underway and will be presented separately.
The Role of Weak Interactions in the Mechano‐induced Single‐Crystal‐to‐Single‐Crystal Phase Transition of 8‐Hydroxyquinoline‐Based Co‐crystals
Authors: Liu Jie , Liu Guangfeng , Liu Yang , Zheng Xiaoxin , Han Quanxiang , Ye Xin , Tao Xutang
Published: April 2016

Mechano‐induced single‐crystal‐to‐single‐crystal (SCSC) phase transitions in crystalline materials that change their properties have received more and more attention. However, there are still too few examples to study molecular‐level mechanisms in the mechano‐induced SCSC phase transitions, making the systematic and in‐depth understanding very difficult. We report that bis‐(8‐hydroxyquinolinato) palladium(II)‐tetracyanoquinodimethane (PdQ2‐TCNQ) and bis‐(8‐hydroxyquinolinato) copper(II)‐tetracyanoquinodimethane (CuQ2‐TCNQ) show very different mechano‐response behaviors during the SCSC phase transition. Phase transition in CuQ2‐TCNQ can be triggered by pricking on the crystal surface, while in PdQ2‐TCNQ it can only be induced by applying pressure uniformly over the whole crystal face. The crystallography data and Hirshfeld surface analysis indicate that the weak intra‐layer C−H⋅⋅⋅O, C−H⋅⋅⋅N hydrogen bonds and inter‐layer stacking interactions determine the feasibility of the SCSC phase transition by mechanical stimuli. Weaker intra‐layer interactions and looser inter‐layer stacking make the SCSC phase transition occur much more easily in the CuQ2‐TCNQ.
Site‐Selective Chlorination of Graphene through Laser‐Induced In Situ Decomposition of AgCl Nanoparticles
Authors: Miao Peng , Chu Jiayu , Chen Yuanfu , Xiong Jie , Hu PingAn , Du Yunchen , Wang Xianjie , Song Bo , Xu Ping
Published: April 2016

Covalent functionalization of graphene offers a great chance to broaden its further applications. Here we demonstrate the site‐selective chlorination of graphene through a laser‐induced in situ decomposition of 3–5 nm AgCl nanoparticles fabricated on the graphene surface by pulsed laser deposition. The chlorination process, using the laser coupled on the Raman instrument, can be monitored by in situ Raman spectroscopy. A structural disorder, which resulted from a change from sp2 to sp3 configuration due to the covalent chlorination, increases the electrical resistance of graphene by over two orders of magnitude. We believe this chlorination process from in situ decomposition of AgCl may open up a new avenue for graphene modification and bandgap modulation.
Magnetic particle characterization—magnetophoretic mobility and particle size
Authors: Zhou Chen , Boland Eugene D. , Todd Paul W. , Hanley Thomas R.
Published: April 2016

Quantitative characterization of magnetic particles is useful for analysis and separation of labeled cells and magnetic particles. A particle velocimeter is used to directly measure the magnetophoretic mobility, size, and other parameters of magnetic particle suspensions. The instrument provides quantitative video analysis of particles and their motion. The trajectories of magnetic particles in an isodynamic magnetic field are recorded using a high‐definition camera/microscope system for image collection. Image analysis software then converts the image data to the parameters of interest. The distribution of magnetophoretic mobility is determined by combining fast image analysis with velocimetry measurements. Particle size distributions have been characterized to provide a better understanding of sample quality. The results have been used in the development and operation of analyzer protocols for counting particle concentrations accurately and measuring magnetic susceptibility and size for simultaneous display for routine application to particle suspensions and magnetically labeled biological cells. © 2016 International Society for Advancement of Cytometry
High level extracellular production of a truncated alkaline β-mannanase from alkaliphilic Bacillus sp. N16-5 in Escherichia coli by the optimization of induction condition and fed-batch fermentation
Authors: Zheng Hongchen , Yu Zhenxiao , Fu Xiaoping , Li Shufang , Xu Jianyong , Song Hui , Ma Yanhe
Published: April 2016

To improve the extracellular production of alkaline β-mannanase from alkaliphilic Bacillus sp. N16-5 in Escherichia coli, two truncated recombinant mannanases (32a-ManAR2 and 22b-ManAR2) were obtained. Compared with the full-length mannanases (32a-ManAR1 and 22b-ManAR1), the truncated mannanases not only showed higher secretion rate, but also exhibited higher thermostability and alkalistability. The K  m value (11 mg/mL) of 32a-ManAR2 was higher than that (1.46 mg/mL) of 32a-ManAR1. The specific activity of 22b-ManAR2 was 2.7 times higher than that of 22b-ManAR1. 22b-ManAR2 showed the highest k  cat/K  m value of 602.7 ml/mg s. The parameters of induction for recombinant mannanase production of E. coli BL21 (pET32a-manAR2) and E. coli BL21 (pET22b-manAR2) were subsequently optimized. The yield of soluble mannanase was found to be enhanced with lower induction temperature (25 °C), lower IPTG concentration (0.01–0.05 mM), and Triton X-100 supplement (0.1 %) in a shake flask. Moreover, a one-time feeding strategy and Triton X-100 supplement were applied in production of 22b-ManAR2 in a 10 L fermentor. The productivity of the total soluble mannanase reached 9284.64 U/mL with the extracellular rate of 74 % at 46 h of fermentation, which was the highest productive level of alkaline β-mannanase in recombinant E. coli to date.
Granulomatous lobular mastitis
Authors: Zhou Fei , Yu Li‐Xiang , Ma Zhong‐Bing , Yu Zhi‐Gang
Published: April 2016

Granulomatous lobular mastitis is an unusual breast benign inflammatory disorder with unknown aetiology. It is generally emerged with the clinical symptoms of breast mass, abscess, inflammation and mammary duct fistula. The diagnosis is made by histopathology with a chronic non‐necrotizing granulomatous inflammation in lobules of the breast tissue as the microscopic feature. Therapy of granulomatous lobular mastitis consists of surgical, medication treatment or combination of both, but now researches suggest that observational management is an acceptable treatment.
Affective Images, Emotion Regulation and Bidding Behavior: An Experiment on the Influence of Competition and Community Emotions in Internet Auctions
Authors: Adam Marc T.P. , Astor Philipp J. , Krämer Jan
Published: April 2016

Internet auction sites frequently employ images as design elements on their websites in order to either induce a sense of community or competition among the bidders. In this paper, we investigate the impact of such affective images on bidding behavior in a controlled laboratory experiment during which participants’ emotional processes are assessed through psychophysiological measurements. Immediately before placing a bid in a first-price sealed-bid auction, bidders are presented a) pictures of competitive sports scenes, b) pictures of families or children, or c) a blank screen. Participants place significantly lower bids when they were exposed to pictures that induce competition emotions as opposed to pictures that induce community emotions. This relationship is moderated by the bidders’ emotion regulation strategy. In particular, we find that the more participants try to suppress their emotional responses to the presented images, the more they are affected in their bidding behavior. Our results entail valuable insights about the coherence of emotional stimuli on Internet auction marketplaces and customers’ decisions. They also question recent marketing strategies by the market leader.
Mobile Shopper Marketing: Key Issues, Current Insights, and Future Research Avenues
Authors: Shankar Venkatesh , Kleijnen Mirella , Ramanathan Suresh , Rizley Ross , Holland Steve , Morrissey Shawn
Published: April 2016

The intersection of mobile marketing and shopper marketing, known as mobile shopper marketing, is a rapidly evolving area. We formally define mobile shopper marketing as the planning and execution of all mobile-based marketing activities that influence a shopper along and beyond the path-to-purchase: from the initial shopping trigger, to the purchase, consumption, repurchase, and recommendation stages. However, not much is known about mobile shopper marketing. We plug this gap by first discussing mobile shopper marketing and its scope in depth and then presenting a process model that connects the mobile shopping journey with four key entities, i.e., shopper, employee, organization, and mobile technology. For each of these themes, we identify the challenges that offer future research opportunities.
Mobile Promotions: A Framework and Research Priorities
Authors: Andrews Michelle , Goehring Jody , Hui Sam , Pancras Joseph , Thornswood Lance
Published: April 2016

This work bridges theory and practice on mobile promotions and proposes a research agenda. We do so by first defining mobile promotions and distinguishing them from mobile advertising. We then develop a framework for various stakeholders in the mobile promotion ecosystem. Finally, we advance research questions concerning each stakeholder and view these questions through the lens of several overarching themes that surround mobile promotions, such as the privacy–value tradeoff, return on investment, spatiotemporal targeting, inter-media substitution, and channel and consumer power.
The Physiology of Female Sexual Function and the Pathophysiology of Female Sexual Dysfunction (Committee 13A)
Authors: Levin Roy J. , Both Stephanie , Georgiadis Janniko , Kukkonen Tuuli , Park Kwangsung , Yang Claire C.
Published: April 2016

Introduction

The article consists of six sections written by separate authors that review female genital anatomy, the physiology of female sexual function, and the pathophysiology of female sexual dysfunction but excluding hormonal aspects.

Aim

To review the physiology of female sexual function and the pathophysiology of female sexual dysfunction especially since 2010 and to make specific recommendations according to the Oxford Centre for evidence based medicine (2009) “levels of evidence” wherever relevant.

Conclusion

Recommendations were made for particular studies to be undertaken especially in controversial aspects in all six sections of the reviewed topics. Despite numerous laboratory assessments of female sexual function, genital assessments alone appear insufficient to characterise fully the complete sexual response.
Holocene climate changes in southern West Siberia based on ostracod analysis
Authors: Khazin L.B. , Khazina I.V. , Krivonogov S.K. , Kuzmin Ya.V. , Prokopenko A.A. , Yi S. , Burr G.S.
Published: April 2016

The study presents a summary of the latest data on ostracod microfaunas from Middle–Upper Holocene lacustrine deposits of southern West Siberia collected from lakes Malye Chany, Bol’shaya Lozhka, Beloe, and paleolake Chicha. A total of 28 ostracod species were identified. The identified ostracod assemblages reveal local variations in the lake ecosystems as well as general trends, which can be correlated with both regional and global climate changes. A cooling episode during the second half of the Subboreal is marked by the transition from a warm-water mesohaline assemblage to cold-water candonid ostracods at ca. 3.4 cal ka BP. The widespread occurrence of mesopolythermophilic ostracod species at 1.9–0.6 cal ka BP indicates the end of cooling and lowering of lake-water level. From 0.6 cal ka BP to present, the ostracod assemblages area characterized by the high specific diversity, which is probably an indication of the increased variability of aquatic ecosystems due to fluctuations in salinity and water levels of the lakes. Climate changes identified by ostracod assemblages are consistent with the climatic trend constrained by early palynological studies.
Deposits of the Kazantsevo Transgression (MIS 5) in the Northern Yenisei Region
Authors: Gusev E.A. , Molodkov A.N. , Streletskaya I.D. , Vasiliev A.A. , Anikina N.Yu. , Bondarenko S.A. , Derevyanko L.G. , Kupriyanova N.V. , Maksimov F.E. , Polyakova E.I. , Pushina Z.V. , Stepanova G.V. , Oblogov G.E.
Published: April 2016

Dating of marine sediments and faunal remains they contain in stratotype and reference sections by the methods of infrared optically stimulated luminescence (IR-OSL) of K-feldspar, optically stimulated afterglow (OSA) of quartz, electron spin resonance (ESR), and 230Th/U provides new constraints on deposition in the Yenisei mouth during the Kazantsevo interglacial. The luminescence and U–Th ages in the 120–68 ka range and 93–70 ka ESR ages show that the deposition spanned the whole marine isotope stage (MIS) 5. The sediment structures and textures, grain sizes and mineralogy, and faunal records indicate tidal and shelf deposition environments. The sampled assemblages of marine mollusks comprise taxa that typically live in relatively shallow and warm water, as well as abundant subarctic and boreal species, including the Arctica islandica index species. The variations of faunal patterns, more likely, had facies rather than climatic controls, while the sediments were deposited during transgression, in a warm climate, when the area was ice-free.
Economic and Greenhouse Gas Emission Response to Pasture Species Composition, Stocking Rate, and Weaning Age by Calving Season, Farm Size, and Pasture Fertility
Authors: Smith S. Aaron , Popp Michael P. , Keeton Daniel R. , West Charles P. , Coffey Kenneth P. , Nalley L. Lanier , Brye Kristofor R.
Published: April 2016

Since cow-calf operations are large contributors of agricultural greenhouse gas (GHG) emissions in North America, consequences of pasture species composition, weaning age, and stocking rate decisions were examined by operation size, calving season, and pasture fertility. Fixed resource use and seasonal prices affected the mix of forage and beef production. Overall, adding fertilizer to pasture was unprofitable, resulting in increased stocking rates and greater emissions. Calving season and attendant breeding failure rates influenced the relative profitability of the analyzed beef-production strategies, which in turn affected farm GHG emissions. More-efficient practices led to greater amounts of beef sold per bred cow.
What Attributes Are Consumers Looking for in Sweet Cherries? Evidence from Choice Experiments
Authors: Zheng Xibei , Yue Chengyan , Gallardo Karina , McCracken Vicki , Luby James , McFerson Jim
Published: April 2016

We investigate heterogeneous consumer preferences and willingness to pay (WTP) for various sweet cherry attributes using choice experiments. A mixed logit model and a latent-class logit model are used to estimate consumer WTP for the attributes and identify groups of consumers based on those preferences. We find that consumers of sweet cherries will pay the greatest premium for sweetness and the smallest premium for fruit size. Three groups of consumers are identified—flavor sensitive, price sensitive, and storage sensitive. The results are useful for suppliers of sweet cherries when adopting targeted marketing strategies.
Food Safety Information, Changes in Risk Perceptions, and Offsetting Behavior
Authors: Nganje William , Miljkovic Dragan , Voica Daniel
Published: April 2016

Decreased care or offsetting behavior by potential victims can reduce or reverse benefits provided by some safety policies. We explore reasons for offsetting behavior associated with food safety policies using a survey of a nationally representative sample of almost 3,000 consumers. Results reveal that positive food safety information can change consumers’ risk perceptions and attitudes, causing them to be less vigilant and to consume more of relatively unsafe foods. This behavioral anomaly plausibly explains ongoing incidences of food poisoning after a meat processing facility implements a pathogen-reduction hazard analysis of critical control points (PR/HACCP).
Assessing the Economic Impacts of Food Hubs on Regional Economies: A Framework that Includes Opportunity Cost
Authors: Jablonski B. B. R. , Schmit T. M. , Kay D.
Published: April 2016

The number of food hubs—businesses that aggregate and distribute local food—in the United States is growing, fueled in part by increasing public support. However, there have been few data-driven assessments of the economic impacts of these ventures. Using an input-output-based methodology and a unique data set from a successful food hub, we measure net and gross impacts of a policy supporting their development. We estimate a gross output multiplier of 1.75 and an employment multiplier of 2.14. Using customer surveys, we estimate that every $1 increase in final demand for food hub products generates a $0.11 reduction in purchases in other sectors.
Cryogenic nanosecond and picosecond high average and peak power (HAPP) pump lasers for ultrafast applications
Authors: Brown David C. , Tornegård Sten , Kolis Joseph
Published: April 2016

Using cryogenic laser technology, it is now possible to design and demonstrate lasers that have concomitant high average and peak powers, with near-diffraction-limited beam quality. We refer to these new laser systems as HAPP lasers. In this paper, we review important laser crystal materials properties at cryogenic temperature, with an emphasis on Yb lasers, and discuss the important design considerations, including the laser-induced damage threshold, nonlinear effects and thermal effects. A comprehensive model is presented to describe diode pulsed pumping with arbitrary duration and repetition rate, and is used with the Frantz–Nodvik equation to describe, to first order, the performance of HAPP laser systems. A computer code with representative results is also described.
ECONOMIC EVALUATION STUDIES OF SELF-MANAGEMENT INTERVENTIONS IN CHRONIC DISEASES: A SYSTEMATIC REVIEW
Authors: van Eeden Mitchel , van Heugten Caroline M. , van Mastrigt Ghislaine A.P.G. , Evers Silvia M.A.A.
Published: April 2016

Background:To our knowledge, there has been no overall systematic review focusing on the methodological quality of full economic evaluation studies of self-management interventions. Our objective was to systematically review the literature of full economic evaluation studies of self-management interventions in adult chronic patients and to investigate their methodological quality and cost-effectiveness.

Methods:A data extraction form was developed to assess general and randomized controlled trial (RCT) -related characteristics, quality, of the RCTs, economic information and quality of the economic evaluation studies by means of a quality assessment (CHEC-list for trial-based studies, adjusted CHEC-list for model-based studies).

Results:Twenty-three reports were found. Sixteen studies (73 percent) lack information on the control intervention(s). Only one study fulfilled all three criteria for quality of RCTs and five studies (23 percent) did not meet any of these criteria. This review included one model-based study; the other studies were trial-based economic evaluation studies based on a RCT. Eight studies (35 percent) used a societal perspective and 12 (60 percent) synthesized costs and effects. Seven studies were categorized into the highest category (<15 score), nine studies into the “moderate” group (9–14 score), six studies received a “low” score (<8) on the CHEC-list. Eighteen studies found the self-management intervention(s) to be cost-effective compared with other interventions

Conclusions:Self-management interventions for adult chronic patients were heterogeneous and there was no clear, well-considered definition of self-management. Overall, the methodological quality of the full economic evaluation studies was moderate and, therefore, cost-effectiveness results must be interpreted with caution. Future research will benefit from further improvements in methodological quality of both economic study design and analysis, as well as a taxonomy for describing self-management interventions and their contents.
The Advisory Jurisdiction of the International Tribunal for the Law of the Sea: Comments on theRequest for an Advisory Opinion Submitted by the Sub-Regional Fisheries Commission
Authors: LANDO MASSIMO
Published: April 2016

In theRequest for an Advisory Opinion Submitted by the Sub-Regional Fisheries Commission, the International Tribunal for the Law of the Sea (ITLOS) was called upon to clarify the existence of its advisory jurisdiction as a full Tribunal under the UN Convention on the Law of the Sea (UNCLOS). ITLOS unanimously upheld its advisory jurisdiction, yet its reasoning is not convincing. ITLOS’s interpretation of Article 21 of its Statute appears unpersuasive. The article discusses the interpretation of Article 21 ITLOS Statute pursuant to the rules on interpretation of the Vienna Convention on the Law of Treaties (Arts. 31–33). First, the article addresses the article's textual reading, and criticizes the Tribunal's interpretation of the term ‘matters’. Second, the article considers the interpretation of Article 21 according to the subsequent practice of the parties, argued by some states but not addressed by ITLOS. Third, thetravaux préparatoiresof the UNCLOS are examined, with a view to understanding whether the drafters intended the Tribunal to have advisory jurisdiction. Fourth, the six authentic texts of UNCLOS are compared in order to highlight potential differences that may help understand the exact meaning of the provision. Fifth, the article discusses the relationship between advisory jurisdiction and state consent. The conclusion is that the basis for ITLOS's advisory jurisdiction under UNCLOS seems weak. Some general considerations conclude the article, together with a possible solution that takes stock of ITLOS's decision.
Legal Recharacterization and the Materiality of Facts at the International Criminal Court: Which Changes Are Permissible?
Authors: FRY ELINOR
Published: April 2016

The ICC's Regulation 55, which allows the Trial Chamber to modify the legal characterization of facts in the final judgment, has been used too often and too carelessly. Recharacterization must not exceed the facts and circumstances described in the charges, but material facts and their legal qualification are like communicating vessels; changing the latter affects the former (and vice versa). In their application of Regulation 55 to date, chambers have underappreciated this, treating cases as if they have blurry factual boundaries where material facts can be swapped, neglected, or created at will. This article is not a plea for abolition of Regulation 55, though, but explores which modifications are permissible, and finds that when comparing a change regarding the contextual elements or (sub)categories of crimes to a change regarding the mode of participation the latter is most problematic and often detrimental to the rights of the accused.
The Ethos of State and Society in the Early Mongol Empire: Chinggis Khan to Güyük
Authors: BUELL PAUL D. , KOLBAS JUDITH
Published: April 2016

The following joint article is a departure from standard studies, in that historical research is put side-by-side with numismatic evidence. It reflects the growing awareness of the underlying concepts of steppe society that significantly shaped the formation and endurance of the Mongol Empire. With new analysis, it is apparent that the society was clear about these concepts and expressed them in very public pronouncements. They are most evident in the early period of the empire; during the formation of the state by Chinggis Khan and his first two successors, Ögödei (r. 1229–41) and Güyük (r.1246-48). However, the cataclysmic civil war in the middle of the thirteenth century between the Ögödeyids and Toluids removed direct acknowledgment of such a social ethos. Indeed, after 1250 khans strongly focused on pragmatic issues and relied less on philosophical theories of legitimacy, at least Mongolian ones. By contrast, the first three rulers were keenly aware of the theory of the state and the way society functioned within it. They developed this ethos into a fairly cohesive form that provided moral strength to a nascent regime. The evidence for this development emerges from the study of two particular words, tengri, “Heaven”, and especially töre, “grand principle”. Töre in this usage was the equivalent of the ‘binding and unbinding’ and the sunna of the messenger, Muḥammad, in medieval Islamic societies and of democracy in modern times. Tengri and töre are culturally defined theories closely related to the Aristotelian sense of positive law. In all cases, reality required various approaches to them at a given period of time. As a result, the concept of töre had existed before the empire and continues to this day, always implying the correct order of good governance.
If the Cap Fits: Going Mongol in Thirteenth Century Syria
Authors: STEWART ANGUS
Published: April 2016

Various Near Eastern and European writers of the thirteenth century remarked on the outlandish appearance of the Mongol warriors then rampaging across Eurasia. One aspect of this was their distinctive headgear. From our sources it is clear that Mongol costume could be exploited by non-Mongols in the Near East for a variety of purposes; how these distinctive hats were described, and how contemporary artists depicted them, will also be discussed.
Rivers of Memory and Oceans of Difference in the Lumad World of Mindanao
Authors: Paredes Oona
Published: April 2016

This article explores the relevance of water in the cultural traditions of indigenous Lumad peoples of Mindanao island in the southern Philippines. Historically, Lumad identities and networks (whether political, social, or economic) were conceptualised according to the rivers on which people dwelt. Important ties stretched from the coast to the interior (i.e., between upriver and downriver communities), with water providing the path of least resistance in rough terrain. This stands in contrast to the present-day cultural and political divide between the uplands and lowlands, which are now dominated by mainstream ‘Filipino’ settlers, referred to locally as dumagat or ‘sea-people’. Given that Lumad ties to the land are profoundly visualised according to rivers, the salt-water origins of dumagats locate these interlopers at, or more often, beyond the moral boundaries of the Lumad universe. Meanwhile, in Lumad oral traditions, the movements of people across one generation to the next are traced according to river systems they have occupied, with proximity to water often equated with degree of civilization and cultural purity. Despite the passage of time, and decreased linear proximity from the original rivers, these primal riverine origins remain significant in the present day, as Lumads continue to socially prioritise the genealogies and networks of traditional political authority that are upstreamed from these oral traditions. Focusing on field data from the Higaunon ethnic group of northern Mindanao, this article analyses five examples of water being employed as a hermeneutic for how Lumads locate themselves in relation to other ethnic groups, the state, modern Filipino society, and their own cultural traditions.
Raynaud’s phenomenon and digital ischaemia - pharmacologic approach and alternative treatment options
Authors: Linnemann Birgit , Erbe Matthias
Published: April 2016

Abstract. The primary goal of therapy is to reduce the frequency and intensity of Raynaud’s attacks and to minimize the related morbidity rather than to cure the underlying condition. Treatment strategies depend on whether Raynaud’s phenomenon (RP) is primary or secondary. All patients should be instructed about general measures to maintain body warmth and to avoid triggers of RP attacks. Pharmacologic intervention can be useful for patients with severe and frequent RP episodes that impair the patient’s quality of life. Calcium channel blockers are currently the most prescribed and studied medications for this purpose. There has been limited evidence for the efficacy of alpha-1-adrenergic receptor antagonists, angiotensin receptor blockers, topical nitrates or fluoxetine to treat RP. The intravenously administered prostacyclin analogue iloprost can reduce the frequency and severity of RP attacks and is considered a second-line therapy in patients with markedly impaired quality of life, critical digital ischaemia and skin ulcers who are at risk for substantial tissue loss and amputation. Phosphodiesterase inhibitors (e.g., sildenafil) can also improve RP symptoms and ulcer healing whereas endothelin-1 receptor antagonists (e.g., bosentan) are mainly considered treatment options in secondary prevention for patients with digital skin ulcers related to systemic sclerosis. However, their use in clinical practice has been limited by their high cost. Antiplatelet therapy with low-dose aspirin is recommended for all patients who suffer from secondary RP due to ischaemia caused by structural vessel damage. Anticoagulant therapy can be considered during the acute phase of digital ischaemia in patients with suspected vascular occlusive disease attributed to the occurrence of new thromboses. In patients with critical digital ischaemia, consideration should be given to hospitalisation, optimisation of medical treatment in accordance with the underlying disease and evaluation for a secondary, possibly reversible process that is causing or aggravating the clinical symptoms.
Sterile post‐traumatic immunosuppression
Authors: Islam Md Nahidul , Bradley Benjamin A , Ceredig Rhodri
Published: April 2016

After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. This local immune response involves complex interactions between resident cells such as macrophages and dendritic cells, soluble mediators such as cytokines and chemokines, and recruited cells such as neutrophils, monocytes and mesenchymal stromal cells. If of sufficient magnitude, these initial immune responses nevertheless have systemic consequences resulting in a state called post‐traumatic immunosuppression (PTI). However, controversy exists regarding the exact immunological changes occurring in systemic compartments triggered by these local immune responses. PTI is one of the leading causes of post‐surgical mortality and makes patients vulnerable to hospital‐acquired infections, multiple organ failure and many other complications. In addition, hemorrhage, blood transfusion, immunesenescence and immunosuppressant drugs aggravate PTI. PTI has been intensively studied, but published results are frequently cloudy. The purpose of this review is to focus on the contributions made by different responsive modalities to immunosuppression following sterile trauma and to try to integrate these into an overall scheme of PTI.
Gut macrophage phenotype is dependent on the tumor microenvironment in colorectal cancer
Authors: Norton Samuel E , Dunn Elliott T J , McCall John L , Munro Fran , Kemp Roslyn A
Published: April 2016

In contrast to many cancers, a high infiltration of macrophages in colorectal cancer (CRC) has been associated with improved prognosis for patients. Cytokines and other stimuli from the tumor microenvironment affect monocyte to macrophage maturation and subsequent phenotype and function. Heterogeneous myeloid populations were identified using a novel flow cytometry panel in both tumor and paired non‐tumor bowel (NTB) from CRC patients. The frequency of macrophage subsets with a gut‐conditioned phenotype was lower in tumor compared with NTB. We used an in vitro system to show that two of the macrophage populations represented pro‐inflammatory and anti‐inflammatory phenotypes. Conditioned media that contained high levels of interleukin‐6 promoted and maintained an anti‐inflammatory phenotype in vitro. This study demonstrates the plasticity and heterogeneity of macrophage subtypes in human CRC, and the feasibility of studying complex populations. Ex vivo experiments demonstrate that macrophage subsets are influenced by the tumor microenvironment.
A genomic comparison of 13 symbiotic Vibrio fischeri isolates from the perspective of their host source and colonization behavior
Authors: Bongrand Clotilde , Koch Eric J , Moriano-Gutierrez Silvia , Cordero Otto X , McFall-Ngai Margaret , Polz Martin F , Ruby Edward G
Published: April 2016

Newly hatched Euprymna scolopes squid obtain their specific light-organ symbionts from an array of Vibrio (Allivibrio) fischeri strains present in their environment. Two genetically distinct populations of this squid species have been identified, one in Kaneohe Bay (KB), and another in Maunaloa Bay (MB), Oahu. We asked whether symbionts isolated from squid in each of these populations outcompete isolates from the other population in mixed-infection experiments. No relationship was found between a strain’s host source (KB or MB) and its ability to competitively colonize KB or MB juveniles in a mixed inoculum. Instead, two colonization behaviors were identified among the 11 KB and MB strains tested: a ‘dominant’ outcome, in which one strain outcompetes the other for colonization, and a ‘sharing’ outcome, in which two strains co-colonize the squid. A genome-level comparison of these and other V. fischeri strains suggested that the core genomic structure of this species is both syntenous and highly conserved over time and geographical distance. We also identified ~250 Kb of sequence, encoding 194 dispersed orfs, that was specific to those strains that expressed the dominant colonization behavior. Taken together, the results indicate a link between the genome content of V. fischeri strains and their colonization behavior when initiating a light-organ symbiosis.
Integrated Droplet-Based Microextraction with ESI-MS for Removal of Matrix Interference in Single-Cell Analysis
Authors: Zhang Xiao-Chao , Wei Zhen-Wei , Gong Xiao-Yun , Si Xing-Yu , Zhao Yao-Yao , Yang Cheng-Dui , Zhang Si-Chun , Zhang Xin-Rong
Published: April 2016

Integrating droplet-based microfluidics with mass spectrometry is essential to high-throughput and multiple analysis of single cells. Nevertheless, matrix effects such as the interference of culture medium and intracellular components influence the sensitivity and the accuracy of results in single-cell analysis. To resolve this problem, we developed a method that integrated droplet-based microextraction with single-cell mass spectrometry. Specific extraction solvent was used to selectively obtain intracellular components of interest and remove interference of other components. Using this method, UDP-Glc-NAc, GSH, GSSG, AMP, ADP and ATP were successfully detected in single MCF-7 cells. We also applied the method to study the change of unicellular metabolites in the biological process of dysfunctional oxidative phosphorylation. The method could not only realize matrix-free, selective and sensitive detection of metabolites in single cells, but also have the capability for reliable and high-throughput single-cell analysis.
Global diabatic potential energy surfaces and quantum dynamical studies for the Li(2p) + H2(X1Σ+g) → LiH(X1Σ+) + H reaction
Authors: He Di , Yuan Jiuchuang , Li Huixing , Chen Maodu
Published: April 2016

The global diabatic potential energy surfaces which are correlated with the ground state 1A′ and the excited state 2A′ of the Li(2p) + H2 reaction are presented in this study. The multi-reference configuration interaction method and large basis sets (aug-cc-pVQZ for H atom and cc-pwCVQZ for Li atom) were employed in the ab initio single-point energy calculations. The diabatic potential energies were generated by the diabatization scheme based on transition dipole moment operators. The neural network method was utilized to fit the matrix elements of the diabatic energy surfaces, and the root mean square errors were extremely small (3.69 meV for "Equation missing", 5.34 meV for "Equation missing" and 5.06 meV for "Equation missing"). The topographical features of the diabatic potential energy surfaces were characterized and the surfaces were found to be sufficiently smooth for the dynamical calculation. The crossing seam of the conical intersections between the "Equation missing" and "Equation missing" surfaces were pinpointed. Based on this new analytical diabatic potential energy surfaces, time-dependent wave packet calculation were conducted to investigate the mechanism of the title reaction. At low collision energies, the product LiH molecule tends to forward scattering, while at high collision energies, the forward and backward scatterings exist simultaneously.
A Mendelian Randomization Study of Plasma Homocysteine and Multiple Myeloma
Authors: Xuan Yang , Li Xiao-Hong , Hu Zhong-Qian , Teng Zhi-Mei , Hu Dao-Jun
Published: April 2016

Observational studies have demonstrated an association between elevated homocysteine (Hcy) level and risk of multiple myeloma (MM). However, it remains unclear whether this relationship is causal. We conducted a Mendelian randomization (MR) study to evaluate whether genetically increased Hcy level influences the risk of MM. We used the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism as an instrumental variable, which affects the plasma Hcy levels. Estimate of its effect on plasma Hcy level was based on a recent genome-wide meta-analysis of 44,147 individuals, while estimate of its effect on MM risk was obtained through meta-analysis of case-control studies with 2,092 cases and 4,954 controls. By combining these two estimates, we found that per one standard-deviation (SD) increase in natural log-transformed plasma Hcy levels conferred a 2.67-fold increase in risk for MM (95% confidence interval (CI): 1.12–6.38; P = 2.7 × 10−2). Our study suggests that elevated Hcy levels are causally associated with an increased risk of developing MM. Whether Hcy-lowering therapy can prevent MM merits further investigation in long-term randomized controlled trials (RCTs).
Hand, Foot, and Mouth Disease in China: Critical Community Size and Spatial Vaccination Strategies
Authors: Van Boeckel Thomas P. , Takahashi Saki , Liao Qiaohong , Xing Weijia , Lai Shengjie , Hsiao Victor , Liu Fengfeng , Zheng Yaming , Chang Zhaorui , Yuan Chen , Metcalf C. Jessica E. , Yu Hongjie , Grenfell Bryan T.
Published: April 2016

Hand Foot and Mouth Disease (HFMD) constitutes a considerable burden for health care systems across China. Yet this burden displays important geographic heterogeneity that directly affects the local persistence and the dynamics of the disease, and thus the ability to control it through vaccination campaigns. Here, we use detailed geographic surveillance data and epidemic models to estimate the critical community size (CCS) of HFMD associated enterovirus serotypes CV-A16 and EV-A71 and we explore what spatial vaccination strategies may best reduce the burden of HFMD. We found CCS ranging from 336,979 (±225,866) to 722,372 (±150,562) with the lowest estimates associated with EV-A71 in the southern region of China where multiple transmission seasons have previously been identified. Our results suggest the existence of a regional immigration-recolonization dynamic driven by urban centers. If EV-A71 vaccines doses are limited, these would be optimally deployed in highly populated urban centers and in high-prevalence areas. If HFMD vaccines are included in China’s National Immunization Program in order to achieve high coverage rates (>85%), routine vaccination of newborns largely outperforms strategies in which the equivalent number of doses is equally divided between routine vaccination of newborns and pulse vaccination of the community at large.
An automatic tooth preparation technique: A preliminary study
Authors: Yuan Fusong , Wang Yong , Zhang Yaopeng , Sun Yuchun , Wang Dangxiao , Lyu Peijun
Published: April 2016

The aim of this study is to validate the feasibility and accuracy of a new automatic tooth preparation technique in dental healthcare. An automatic tooth preparation robotic device with three-dimensional motion planning software was developed, which controlled an ultra-short pulse laser (USPL) beam (wavelength 1,064 nm, pulse width 15 ps, output power 30 W and repeat frequency rate 100 kHz) to complete the tooth preparation process. A total of 15 freshly extracted human intact first molars were collected and fixed into a phantom head and the target preparation shapes of these molars were designed using customised computer-aided design (CAD) software. The accuracy of tooth preparation was evaluated using the Geomagic Studio and Imageware software and the preparing time of each tooth was recorded. Compared with the target preparation shape, the average shape error of the 15 prepared molars was 0.05–0.17 mm, the preparation depth error of the occlusal surface was approximately 0.097 mm and the error of the convergence angle was approximately 1.0°. The average preparation time was 17 minutes. These results validated the accuracy and feasibility of the automatic tooth preparation technique.
Growth Mechanism of Strain-Dependent Morphological Change in PEDOT:PSS Films
Authors: Lee Yoo-Yong , Choi Gwang Mook , Lim Seung-Min , Cho Ju-Young , Choi In-Suk , Nam Ki Tae , Joo Young-Chang
Published: April 2016

Understanding the mechanism of the strain-dependent conductivity change in polymers in stretched conditions is important. We observed a strain-induced growth of the conductive regions of PEDOT:PSS films, induced by a coalescence of conductive PEDOT-rich cores. This growth due to coalescence leads to a gradual decrease in the electrical resistivity up to 95%, independent of the thickness of the PEDOT:PSS films. The primary mechanism for the evolution of the PEDOT-rich cores proceeds by the cores growing larger as they consuming relatively smaller cores. This process is caused by a strain-induced local rearrangement of PEDOT segments in the vicinity of PSS shells around the cores and also changes the chemical environment in PEDOT, induced by the electron-withdrawing effects around the PEDOT chains. The strain-induced growth mechanism is beneficial to understanding the phenomenon of polymeric chain rearrangement in mechanical deformation and to modulating the electrical conductivity for practical applications.