bluuebunny/crossref_metadata_2025 huggingface dataset:
Vaccination against HPV: Theoretical Aspects and Practical Results of Cervical Cancer Prevention
Authors: Zarochentseva N. V. , Trushina O. I. , Novikova E. G , Baranov I. I. , Lopukhov P. D. , Rovinskaya O. V.
Published: January 2020

Relevance.Cervical cancer (CC) continues to be the focus of attention of oncologists all over the world due to the fact that the incidence of it over the past decades has not tended to decrease. The steady increase in morbidity, high mortality rates, and the tendency to «rejuvenate» the disease, the relatively low detection rate of the early stages of the disease due to poor results of cytological screening predetermine the search for new scientifically based approaches to solving cervical cancer problems. A promising direction for the prevention of squamous cell carcinoma and adenocarcinoma associated with human papillomavirus (HPV) is prophylactic vaccination against HPV, the need for which is due to the role of HPV infection in carcinogenesis processes.

The aimof this article is to summarize the currently available data on advances in the prevention of precancerous lesions and cervical cancer, primarily through vaccination against HPV infection.

Conclusions.The creation of vaccines for the prevention of oncogenic HPV types is a significant achievement in the biomedical research area. The successful development of a group of vaccines, which can confidently be called the vaccines of the 21st century, gives us hope that modern medicine has the potential to reduce population cancer risk and reduce the likelihood of early onset of cervical cancer. Demonstration of the efficacy and feasibility of routine HPV vaccination programs in a number of countries demonstrates encouraging progress in solving cervical cancer problems. Vaccination against HPV will not only ensure epidemiological well-being, but also lead to a decrease in morbidity and mortality from such a terrible complication of human papillomavirus infection – cervical cancer.
Cervical disc replacement: examining “real-world” utilization of an emerging technology
Authors: Witiw Christopher D. , Smieliauskas Fabrice , Ham Sandra A. , Traynelis Vincent C.
Published: January 2020

OBJECTIVE

Cervical disc replacement (CDR) has emerged as an alternative to anterior cervical discectomy and fusion (ACDF) for the management of cervical spondylotic pathology. While much is known about the efficacy of CDR within the constraints of a well-controlled, experimental setting, little is known about general utilization. The authors present an analysis of temporal and geographic trends in “real-world” utilization of CDR among those enrolled in private insurance plans in the US.

METHODS

Eligible subjects were identified from the IBM MarketScan Databases between 2009 and 2017. Individuals 18 years and older, undergoing a single-level CDR or ACDF for cervical radiculopathy and/or myelopathy, were identified. US Census divisions were used to classify the region where surgery was performed. Two-level mixed-effects regression modeling was used to study regional differences in proportional utilization of CDR, while controlling for confounding by regional case-mix differences.

RESULTS

A total of 47,387 subjects met the inclusion criteria; 3553 underwent CDR and 43,834 underwent ACDF. At a national level, the utilization of single-level CDR rose from 5.6 cases for every 100 ACDFs performed in 2009 to 28.8 cases per 100 ACDFs in 2017. The most substantial increases occurred from 2013 onward. The region of highest utilization was the Mountain region (Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, and Wyoming), where 14.3 CDRs were performed for every 100 ACDFs (averaged over the 9-year period of study). This is in contrast to the East South Central region (Alabama, Kentucky, Mississippi, and Tennessee), where only 2.1 CDRs were performed for every 100 ACDFs. Patient factors that significantly increased the odds of undergoing a CDR were age younger than 40 years (OR 15.9 [95% CI 10.0–25.5]; p < 0.001), no clinical evidence of myelopathy/myeloradiculopathy (OR 1.5 [95% CI 1.4–1.7]; p < 0.001), and a Charlson Comorbidity Index score of 0 (OR 2.7 [95% CI 1.7–4.2]; p < 0.001). After controlling for these factors, significant differences in utilization rates remained between regions (chi-square test = 830.4; p < 0.001).

CONCLUSIONS

This US national level study lends insight into the rate of uptake and geographic differences in utilization of the single-level CDR procedure. Further study will be needed to ascertain specific factors that predict adoption of this technology to explain observed geographic discrepancies.
Biomechanical evaluation of two alternative techniques to the Goel-Harms technique for atlantoaxial fixation: C1 lateral mass–C2 bicortical translaminar screw fixation and C1 lateral mass–C2/3 transarticular screw fixation
Authors: Du Yue-Qi , Li Teng , Ma Chao , Qiao Guang-Yu , Yin Yi-Heng , Yu Xin-Guang
Published: January 2020

OBJECTIVE

The authors conducted a study to investigate the biomechanical feasibility and stability of C1 lateral mass–C2 bicortical translaminar screw (C1LM-C2TL) fixation, C1 lateral mass–C2/3 transarticular screw (C1LM-C2/3TA) fixation, and C1LM-C2/3TA fixation with transverse cross-links (C1LM-C2/3TACL) as alternative techniques to the Goel-Harms technique (C1 lateral mass–C2 pedicle screw [C1LM-C2PS] fixation) for atlantoaxial fixation.

METHODS

Eight human cadaveric cervical spines (occiput–C7) were tested using an industrial robot. Pure moments that were a maximum of 1.5 Nm were applied in flexion-extension (FE), lateral bending (LB), and axial rotation (AR). The specimens were first tested in the intact state and followed by destabilization (a type II odontoid fracture) and fixation as follows: C1LM-C2PS, C1LM-C2TL, C1LM-C2/3TA, and C1LM-C2/3TACL. For each condition, the authors evaluated the range of motion and neutral zone across C1 and C2 in all directions.

RESULTS

Compared with the intact spine, each instrumented spine significantly increased in stability at the C1–2 segment. C1LM-C2TL fixation demonstrated similar stability in FE and LB and greater stability in AR than C1LM-C2PS fixation. C1LM-C2/3TA fixation was equivalent in LB and superior in FE to those of C1LM-C2PS and C1LM-C2TL fixation. During AR, the C1LM-C2/3TA–instrumented spine failed to maintain segmental stability. After adding a cross-link, the rotational stability was significantly increased in the C1LM-C2/3TACL–instrumented spine compared with the C1LM-C2/3TA–instrumented spine. Although inferior to C1LM-C2TL fixation, the C1LM-C2/3TACL–instrumented spine showed equivalent rotational stability to the C1LM-C2PS–instrumented spine.

CONCLUSIONS

On the basis of our biomechanical study, C1LM-C2TL and C1LM-C2/3TACL fixation resulted in satisfactory atlantoaxial stabilization compared with C1LM-C2PS. Therefore, the authors believe that the C1LM-C2TL and C1LM-C2/3TACL fixation may serve as alternative procedures when the Goel-Harms technique (C1LM-C2PS) is not feasible due to anatomical constraints.
PENERAPAN METODE FAST TERHADAP PENGEMBANGAN SIM-RS UNTUK PENINGKATAN PELAYANAN DI RUMAH SAKIT
Authors: Putri Nur Rahma  , Makhrajani Madjid  , Herlina  , Ayu Dwi Putri Rusman  , Noer Bahry Noer  , Fridawati Rifai
Published: January 2020

Penerapan SIM telah diamanatkan oleh Undang-undang untuk segera diterapkan yakni pada

 

Nomor 44 Tahun 2009 Pasal 52. Penelitian ini bertujuan untuk Mengetahui kendala yang menjadi factor penghambat dalam penerapan system informasi manajemen di rumah sakit. Menghasilkan strategi paling efektif yang dapat mengoptimalkan penerapan system informasi manajemen di rumah sakit. Menggunakan metode FAST dalam merancang system informasi managemen rumah sakit dirumah sakit. Metode yang digunakan kualitatif dan kuantitatif. Metode kualitatif pada penelitian ini digunakan untuk membantu proses identifikasi, dalam metodologi pengembangan sistem informasi manajemen rumah sakit dalam guna mendukung keputusan manajemen pelayanan. Metode kuantitatif digunakan untuk mengevaluasi kualitas informasi sebelum dan sesudah pengembangan sistem informasi.Hasil penelitian menunjukkan kendala utama belum diterapkannya system informasi manajemen di rumah sakit adalah mahalnya biaya membangun system informasi manajemen, Strategi yang efektif untuk menerapkan system informasi manajemen di rumah sakit adalah perkuat komitmen manajemen rumah sakit bahwa sistem informasi manajemen akan berjalan, Dengan metode FAST dapat memperbaiki kualitas informasi melalui aplikasi system informasi manajemen di rumah sakit. Sistem informasi yang dikembangkan perlu diaplikasikan secara on-line dengan menggunakan Local Area Network untuk penggunaan multiuser
PENDAMPINGAN KONSELING PEVENTIF KANKER SERVIKS BERBASIS HEALTHY CITY PADA KELOMPOK MAJELIS TAKLIM DI KECAMATAN BACUKIKI KOTA PAREPARE
Authors: Makhrajani Majid  , Ayu Dwi Putri Rusman
Published: January 2020

Kanker serviks merupakan kanker yang banyak menyerang perempuan. Melihat perkembangan jumlah penderita dan kematian akibat kanker serviks, diperkirakan bahwa sekitar 10 persen wanita di dunia sudah terineksi Human Pappiloma Virus (HPV). Muncul fakta baru bahwa semua perempuan mempunya risiko untuk terkena infeksi HPV. Infeksi jenis HPV tertentu merupakan penyebab utama kanker serviks hampir 20-100 kali lipat dan kebanyakan diderita oleh perempuan, terutama pada kelompok umur muda. Tujuan penelitian ini untuk membentuk team untuk melakukan kegiatan pendampingan Konseling Preventif Kanker Serviks yang bekerjasama dengan kelompok majelis taklim dan pementukan pos kesehatan dalam melakukan pelayanan yang baik kepada masyarakat. Metode penelitian yang dilakukan dalam tahap identifikasi kepada masyarakat Kelurahan Lapadde dan Kelurahan Bumi Harapan dan tahap implementasi pelayanan kesehatan nantinya akan dibentuk pos kesehatan sebagai media untuk mengontrol perubahan sikap dan pengetahuan masyarakat sebagai upaya preventif kanker serviks. Metode pengabdian kepada masyarakat ini berupa pendampingan konseling preventif dalam bentuk fisik dan intevensi terhadap perubahan sikap dan pengetahuan tentang kanker serviks yang berbasis healthy city. Hasil penelitian ini adalah terbentuknya kelompok preventif (pos kesehatan) bekerja sama dengan pihak mitra dalam bentuk layanan kesehatan berupa pendampingan, berdasakan hasil yang telah didapatkan melalui kegiatan penyuluhan tentang preventif kanker serviks tergolong baik hal ini ditunjukkan dengan bertambahnya pengetahuan dan adanya perubahan sikap untuk melakukan upaya pencegahan kanker seviks dengan menjaga kebesihan oran reproduksi mereka.
HUBUNGAN KUALITAS PELAYANAN KESEHATAN DENGAN KEPUASAN PASIEN PENGGUNA BADAN PENYELENGGARA JAMINAN SOSIAL (BPJS) DI PUSKESMAS MAIWAKABUPATEN ENREKANG
Authors: Nurheda Nurheda , Usman  , Ayu Dwi Putri Rusman
Published: January 2020

Kualitas pelayanan merupakan suatu bentuk penilaian pasien terhadap tingkat pelayanan yang diterima dengan tingkat layanan yang diharapkan. Penelitian ini bertujuan mengetahui hubungan antara kualitas pelayanan kesehatan dengan kepuasan pasien pengguna BPJS yang berkaitan dengan bukti fisik pelayanan, kehandalan pelayanan, tanggapan pelayanan, jaminan pelayanan, dan emphaty pelayanan, di Puskesmas Maiwa Kabupaten Enrekang. Kepuasan adalah suatu tingkat perasaan pasien yang timbul sebagai akibat dari kinerja layanan kesehatan yang diperoleh setelah pasien membandingkan tentang apa yang harapkan. Untuk memperoleh data dilakukan wawancara dengan menggunakan kuesioner dengan 95 responden yang ditentukan dengan teknik accidental sampling. Hasil penelitian menunjukan bahwa adanya hubungan antara kualitas pelayanan kesehatan dengan kepuasan pasien BPJS dimana bukti fisik pelayanan p(0,001), kehandalan pelayanan p(0,402), daya tanggap pelayanan p(0,008), jaminan pelayanan p(0,000), emphaty pelayanan p(0,007). Bagi pihak Puskesmas Maiwa Kabupaten Enrekang perlu mengembangkan sistem informasi manajemen Puskesmas untuk lebih memudahkan pelayanan serta evaluasi cepat terhadap kebutuhan pelayanan
FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP KEJADIAN HIPERTENSI PADA LANSIA DI WILAYAH KERJA PUSKESMAS MAIWA KAB.ENREKANG
Authors: Yuli Hilda Sari  , Usman  , Makhrajani Majid
Published: January 2020

Hipertensi disebut silent killer karena sifatnya asimptomatik dan telah beberapa tahun menimbulkan stroke yang fatal atau penyakit jantung. Meskipun tidak dapat diobati, pencegahan dan penatalaksanaan dapat menurunkan kejadian hipertensi dan penyakit yang menyertainya. Penelitian ini bertujuan untuk membuktikan apakah ada tidaknya pengaruh faktor-faktor yang mempengaruhi terhadap kejadian hipertensi pada lansia di Wilayah Kerja Puskesmas Maiwa Kab.Enrekang. Penelitian ini menggunakan penelitian analitik dengan rancangan cross sectional studi, dengan menggunakan Systematic Random Sampling.  Data dianalisis dengan uji Chi Square, Koefisien phi dengan α 0,05. Sebanyak 77 lansia yang memenuhi kriteria penelitian, uji chi-square bahwa ada pengaruh tingkat stres terhadap kejadian hipertensi pada lansia X2 hit. 72,616 stres dapat menjadi faktor pencetus, penyebab sekaligus akibat dari suatu gangguan atau penyakit , ada pengaruh bertambahnya usia terhadap kejadian hipertensi pada lansia  dengan X2 hit. 34,720 Semakin tinggi umur seseorang semakin tinggi tekanan darahnya, jadi orang yang lebih tua cenderung mempunyai tekanan darah yang tinggi dari orang yang berusia lebih muda.,dan ada pengaruh genetik terhadap kejadian hipertensi pada lansia dengan X2 hit. 41,819 Adanya faktor genetik pada keluarga tertentu akan menyebabkan keluarga itu mempunyai risiko menderita hipertensi. Hasil penelitian ini diharapkan lansia dapat mengontrol tingkat stres dengan baik,mengurangi aktivitas yang melelahkan dan teratur melakukan cek tekanan darah, serta rutin mengikuti posyandu lansia
ANALISIS KONDISI SANITASI LANTAI RUANG DAPUR TERHADAP JUMLAH ANGKA KUMAN DI RSUD ANDI MAKKASAU KOTA PAREPARE
Authors: Dirman Sudarman  , H. Ramlan  , H. Abdul Madjid
Published: January 2020

Pengepelan menggunakan desinfektan adalah usaha untuk membersihkan lantai dengan cara kimiawi untuk mengurangi dan menghilangkan mikroorganisme patogen penyebab penyakit. Dalam hal ini yang perlu diperhatikan adalah desinfektan dan metode yang efektif sehingga dapat tercapai daya bunuh yang optimal pada kuman. Jenis penelitian ini adalah quasi experimental dengan rancangan pretest dan postest. Tujuan penelitian ini adalah adalah unutuk mengetahui kondisi sanitasi lantai ruang dapur sebelum dan sesudah penambahan kadar desinfektan sebanyak 40 ml, 30 ml, dan 20 ml /3 liter air serta menghitung jumlah presentase penurunannya di lakukan 2 kali perhitungan pada setiap media dengan inkubasi selama 24-48 jam. Berdasarkan hasil yang di dapatkan dalam penelitian ini jumlah kuman sebelum penambahan desinfektan di ruang dapur tidak memenuhi syarat pada bagian input 1260-1284 CFU/ , bagian proses 1175-1201 CFU/ , dan bagian output 825-857 CFU/ , tapi setelah penambahan kadar desinfektan 40 ml pada ruang input jumlah 590-607 belum memenuhi syarat, 30 ml untuk ruang proses 554-583 CFU/  belum memnuhi syarat, dan 20 ml untuk ruang output 412-435 CFU/  sudah memenuhi syarat. Berdasarkan Keputusan Menteri kesehatan Republik Indonesia Nomor1204/Menkes/SK/X/2004 tentang Persyaratan kesehatan Lingkungn Rumah Sakit, Persyaratan angka kuman untuk lantai dapur untuk batas maksimum yaitu 500 CFU/ . Dimana kreteria di katakan menemuhi syarat apabila jumlah kuman di <500 CFU/  dan tidak memenuhi syarat apabila jumlah kuman>500 CFU/cm2
ANALISIS KONDISI INTERNAL-EKSTERNAL PENGEMUDI MOBIL TANGKI DALAM PENINGKATAN SAFETY DRIVING PT ELNUSA PETROFIN DI KOTA PAREPARE
Authors: Elmayanti  , Andi Nuddin  , Makhrajani Majid
Published: January 2020

Safety driving merupakan bagian dari budaya keselamatan jalan (road safety culture) yang melihat bagaimana tindakan aman seseorang dalam mengemudi. Terdapat dua faktor yang berhubungan dengan safety driving, yaitu faktor internal dan faktor eksternal. Tujuan penelitian ini untuk menunjukkan faktor apa saja yang berpengaruh terhadap safety driving. Jenis penelitian ini menggunakan metode deskriptif analitik dengan pendekatan Cross Sectional Study. Populasi dalam penelitian ini pengemudi mobil tangki yang bekerja di PT Elnusa Petrofin Parepare. Pengambilan sampel dengan menggunakan metode random sampling sebanyak 64 orang. Analisis data menggunakan uji Chi Square. Ho ditolak jika nilai p<0.05 dan Ha diterima jika nilai p>0.05. Hasil penelitian menunjukkan bahwa dari enam variabel yang diukur pengaruhnya dengan safety driving, lima diantaranya menunjukkan pengaruh yang positif yaitu masa kerja = 0.008, keikutsertaan diklat = 0.015, peran rekan kerja = 0.000, kondisi jalan = 0.000 , dan kondisi cuaca = 0.000 yang berpengaruh terhadap safety driving, sedangkan satu variabel lainnya tidak menunjukkan pengaruh terhadap safety driving dengan p value 0.231. Oleh karena itu disarankan kepada pengemudi untuk mengikuti diklat safety driving dalam meningkatkan kemampuan berkendaraan.
ANALISIS PENERAPAN SISTEM INFORMASI MANAJEMEN RUMAH SAKIT DALAM UPAYA PENINGKATAN PELAYANAN KESEHATAN DI RSUD ANDI MAKKASAU PAREPARE
Authors: Sadriani Hade  , Abidin Djalla  , Ayu Dwi Putri Rusman
Published: January 2020

Sistem Informasi kesehatan adalah salah satu dari enam “building block” atau komponen utama dalam sistem kesehatan di suatu negara dan merupakan suatu pengelolaan informasi di seluruh tingkat pemerintah secara sistematis dalam rangka penyelenggaraan pelayanan kepada masyarakat. Tujuan penelitian ini adalah untuk mengetahui kualitas informasi di Rumah Sakit Andi Makasaau Parepare sebelum dan setelah adanya SIM-RS.Metode penelitian ini menggunakan metode observasi/survey lapangan. Data diperoleh dengan melakukan wawancara kepada 13 responden yang di jadikan sampel mulai bulan Juli sampai Agustus 2018. Analisis penelitian yang diolah secara manual dengan mengelompokkan hasil wawancara sesuai tujuan penelitian. Selanjutnya disajikan secara kualitatif dalam satu matriks dan dalam bentuk analasis isi.Hasil penelitian menunjukkan bahwa ada perbedaan antara sebelum dan sesudah adanya SIM-RS. Rumah Sakit diharapkan mampu mempertahankan dan mengembangkan pemanfaatan teknologi informasi pelayanan kesehatan bagi masyarakat.
ANALISIS FAKTOR-FAKTOR KONSUMSI MINUMAN KERAS (TUAK PAHIT) PADA REMAJA DI DESA BUNTU TABANG KECAMATAN GANDASIL KABUPATEN TANA TORAJA
Authors: Imran Sukiman  , Syarifuddin  , Ilham Willem
Published: January 2020

Minuman keras adalah minuman yang mengandung etanol. Etanol adalah bahan psikoaktif dan konsumsinya menyebabkan penurunan kesadaran. Minuman keras (miras) adalah seluruh jenis minuman yang mengandung zat adiktif (alkohol). Alkohol adalah obat psikoaktif yang paling banyak digunakan. Lebih dari 13 juta orang menganggap dirinya pecandu alkohol (alkoholic). Fenomena penggunaan minuman keras di kalangan remaja dan orang dewasa semakin meningkat. Tujuan penelitian ini adalah untuk menganalisis faktor-faktor konsumsi minuman keras (tuak pahit) pada remaja di desa buntu tabang kecamatan gandasil kabupaten tana toraja. Jenis penelitian ini adalah deskriptif yaitu penelitian yang menggambarkan bagaimana tingkat perilaku, pelayanan kesehatan dan faktor lingkungan remaja yang mengkomsumsi minuman keras (tuak pahit). Sampel dalam penelitian ini adalah 37 anak remaja yang berusia 15-25 tahun, Teknik pengambilan sampel yang digunakan yaitu Total Sampling dimana jumlah sampel sama dengan jumlah populasi. Berdasarkan hasil penelitian yang telah dilakukan bahwa pada Remaja di Desa Buntu Tabang Kecamatan Gandasil Kabupaten Tana Toraja mengkonsumsi minuman keras (tuak pahit) karena dipengaruhi oleh faktor lingkungan dimana hasil penelitian ini menunjukkan kategori yang mendukung yaitu sebanyak 22 orang (59,5%), menurut jenis perilaku masuk dalam kategori yang mendukung yaitu sebanyak 22 orang (59,5%). Sedangkan kategori pelayanan kesehatan yang kurang baik sebanyak 19 (51,3%).
UJI EFEKTIFITAS DAUN ALANG-ALANG (IMPERETA CYLINDRICAL) SEBAGAI ANTI NYAMUK ELEKTRIK TERHADAP KEMATIAN NYAMUK AEDES AEGYPTI
Authors: Muh. Yusran  , Nurhapsa  , Abdul Madjid
Published: January 2020

Setiap tahun ratusan juta kasus penularan penyakit pada manusia melalui serangga yang dikenal dengan  Rthropod Borne disease atau sering juga disebut sebagai Vector borne disease telah menimbulkan tantangan kesehatan masyarakat secara global, karena penyebarannya berlangsung secara luas dan cepat. Penyakit Demam Berdarah Dengue masih merupakan salah satu masalah kesehatan masyarakat yang utama di Indonesia. Jumlah penderita dan luas daerah penyebarannya semakin bertambah seiring dengan meningkatkan mobilitas dan kepadatan penduduk. Penelitian ini bertujuan untuk mengetahui perbedaan  anti nyamuk elektrik daun alang-alang (Imperata Cylindrical) terhadap kematian nyamuk Aedes aegypti  berdasarkan berat konsentrasi daun alang-alang terhadap kematian nyamuk Aedes aegypti dengan 3 kali percobaan pada setiap kelompok perlakuan. Jenis penelitian ini adalah eksperimen semu (Quasi eksperiment) dengan desain penelitian Rancangan Acak Lengkap (RAL). Berdasarkan hasil penelitian yang dilakukan bahwa Kemampuan  anti nyamuk elektrik yang paling efektif membunuh nyamuk Aedes aegypti adalah pada konsentrasi 400 gram, dimana persentasi rata-rata membunuh nyamuk dalam waktu 6 jam mampu membunuh 100% nyamuk Aedes aegypti.
HUBUNGAN POLA KONSUMSI KOPI TERHADAP KEJADIAN GASTRISTIS PADA MAHASISWA MUHAMMADIYAH PAREPARE
Authors: Muhammad Ishak Ilham  , Haniarti  , Usman
Published: January 2020

Kafein di dalam kopi dapat mempercepat proses terbentuknya asam lambung. Hal ini membuat produksi gas dalam lambung berlebih sehingga sering mengeluhkan sensasi kembung di perut. Responden yang sering meminum kopi beresiko 3,57 kali menderita gastritis dibandingkan dengan yang tidak sering meminum kopi.Tujuan penelitian ini adalah untuk mengidentifikasi hubungan pola konsumsi kopi terhadap kejadian gastritis pada Mahasiswa Univesitas Muhammadiyah Parepare.Jenis penelitian ini menggunakan metode deskriptif analitik dengan pendekatan cross sectional. Populasi yaitu mahasiswa yang aktif secara keseluruhan mahasiswa di Universitas Muhammadiyah Parepare sebanyak 8.891 orang. Sampelnya sebanyak 99 orang yang dihitung dengan  menggunakan rumus slovin. Teknik pengambilan sampel dilakukan Purposive Sampling Pengumpulan data dengan menggunakan kuesioner. Hasil penelitian ini menunjukkan bahwa ada hubungan pola konsumsi kopi terhadap kejadian gastritis pada Mahasiswa Universitas Muhammadiyah Parepare. Untuk penderita gastristris maupun bukan penderita gastristis sebaiknya membatasi konsumsi kopi
Effects of tryptophan, a precursor for melatonin, on IVF outcomes and Doppler parameters
Authors: BILDIRCIN Fatma Devran , ÇELİK Handan , ÖZDEMİR Ayşe , KARLI Pervin , AVCI Bahattin , BATIOĞLU Sertaç
Published: January 2020

Aims: Melatonin is the most powerful antioxidant and protects sperm, oocyte and embryo against oxidative stress. The effect of tryptophan, which is the building block of melatonin, on follicular melatonin levels and IVF outcomes is unknown. The objective of this study was to investigate the effect of tryptophan administration, a precursor for melatonin, on the levels of intrafollicular melatonin with the aim to reveal the correlation between tryptophan and the total number and quality of oocytes as well as clinical pregnancy rates. In addition, we aimed to examine the effect of melatonin increased by tryptophan on uterine and ovarian blood flow.
Methods: Out of 103 patients who applied to Ondokuzmayis University IVF clinic for IVF treatment, 51 patients were administered a 100 mg dose of tryptophan orally (Group A) and 50 control patients who were randomly selected did not receive tryptophan (Group B). Firstly, follicular melatonin levels were compared between Group A receiving tryptophan and Group B without tryptophan. Both groups were also compared according to the oocyte count, oocyte count, fertilized oocyte count, embryo count and pregnancy rates, ultimately. In addition, all patients were measured for uterine and ovarian artery blood flow by vaginal ultrasound on the day of OPU..
Results: There were no differences in age (32.16 ± 3.82 years vs 33.06 ± 4.44 years) (p = 0.276), BMI (28.45 ± 2.82 kg/m)2 vs 28.15 ± 3.03kg/m2 (p = 0.602) and peak estradiol levels (2451.69 ± 469.75 pg/ml vs 2420.26 ± 443.71 pg / ml) (p = 0.73) between the groups. Group A exhibited high levels of melatonin in the follicular fluid with a mean value of 259.8 pg/ml, whereas Group B had 91.3 pg/ml (p <0.001). There were found significant differences in the oocyte count (9.08 ± 3.22 vs 7.66 ± 1.89) (p = 0,008), mature oocyte count (7.2 ± 2.8 vs 6.1 ± 1.8) (p = 0,021) and fertilized oocyte count (6.35 ± 2.44 vs 5.28 ± 1.69) between group A and group B. Pregnancy rates were higher in group A (35.3%). The pregnancy rate (30%) was lower in Group B, which did not receive tryptophan and had low melatonin levels in follicular fluid. However, there was no statistically significant difference. Uterine, ovarian artery systolic and diastolic blood flows of Group A were significantly lower than Group B (P <0.001).
Conclusions: Administration of tryptophan to IVF patients significantly increases the level of melatonin in follicular fluid. The results demonstrate that high levels of melatonin in follicular fluid may increase oocyte count and quality although they do not significantly improve clinical pregnancy rates.
A note on optimal L2-estimates of solutions to some strongly damped σ-evolution equations
Authors: Ikehata Ryo
Published: January 2020

We consider the Cauchy problem in [Formula: see text] for the so-called σ-evolution equations with damping terms. We derive asymptotic profiles of solutions with weighted [Formula: see text] initial data, and investigates the optimality of estimates of solutions in [Formula: see text]-sense. The obtained results will generalize and compensate those already known in ( J. Math. Anal. Appl. 478 ( 2019 ) 476–498, J. Diff. Eqns 257 ( 2014 ) 2159–2177, Diff. Int. Eqns 30 ( 2017 ), 505–520).
Kelvin–Voigt equations with anisotropic diffusion, relaxation and damping: Blow-up and large time behavior
Authors: Antontsev S. , de Oliveira H.B. , Khompysh Kh.
Published: January 2020

A nonlinear initial and boundary-value problem for the Kelvin–Voigt equations with anisotropic diffusion, relaxation and absorption/damping terms is considered in this work. The global and local unique solvability of the problem was established in ( J. Math. Anal. Appl. 473(2) ( 2019 ) 1122–1154). In the present work, we show how all the anisotropic exponents of nonlinearity and all anisotropic coefficients should interact with the problem data for the solutions of this problem display exponential and polynomial time-decays. We also establish the conditions for the solutions of this problem to blow-up in a finite time in three different cases: problem without convection, full anisotropic problem, and the problem with isotropic relaxation.
Is BAI better than BMI in estimating the increment of lumbar lordosis for the Caucasian population?
Authors: Zwierzchowska Anna , Tuz Jacek , Grabara Małgorzata
Published: January 2020

BACKGROUND: One of the complications of obesity is low back pain, frequently associated with postural disorders. Body adiposity index (BAI) can be calculated without weighing, which may be rendered useful in settings where measuring accurate body weight is problematic. OBJECTIVE: The aim of this study was to compare two indices of somatic structure, i.e., BAI and BMI regarding their accuracy (specific and sensitive) in predicting postural aberrations. METHODS: The study group comprised of 1281 participants aged 20–22 years, who were students from universities in southern Poland. Anteroposterior spinal curvatures were measured using the Rippstein plurimeter. All subjects were measured for body height (BH) and mass, waist and hip circumference (WC and HC, respectively). RESULTS: In both male and female groups classified according to BAI cut-off points, a significant linear relationship was noted for the lumbar lordosis angle, i.e., the latter increased along with the BAI increase. The analysis of variance confirmed statistically significant differences in lordosis angles in both groups (women f= 19.6, p< 0.001; men f= 21.18, p< 0.001). These data evidenced a weak relationship between LL and the BAI. Pearson correlation coefficient (r) between LL and BAI was 0.2 and 0.21 for men and women, respectively. CONCLUSIONS: We concluded that, contrary to BAI, BMI value did not indicate a significant difference in lumbar lordosis angle between normal weight and obese participants (women and men).
Long-term effect of high-intensity laser therapy for persistent shoulder pain: A case report
Authors: Aceituno-Gómez Javier , García-Madero Venancio Miguel , Criado-Álvarez Juan José , González-González Jaime , Gómez-Soriano Julio , Avendaño-Coy Juan
Published: January 2020

BACKGROUND AND OBJECTIVE: This case report describes the long-term effect of the high-intensity laser therapy (HILT) in a patient with chronic shoulder pain refractory in comparison to other treatments. CASE DESCRIPTION: Ten sessions of HILT were applied in a thirty-one-year-old woman diagnosed with subacromial syndrome. Assessment was carried out through different tests: Shoulder Pain and Disability Index (SPADI), Numeric Pain Rating Scale (NPRS) and pressure pain threshold (PPT). All measurements were taken at four different points: at the end of the 10 sessions, after one month, three months after the intervention and nine months after the initial intervention. RESULTS: There was a clinically significant improvement in NPRS (decrease of 5 points), PPT (increase of 1.5 kg/cm2) and SPADI (decrease of 24 points) one month after the intervention. After three months, the increase of NPRS and SPADI required a 5-session intervention to support the clinical improvement. Six months after these booster sessions an increase in PPT and a decrease in NPRS and SPADI were observed. CONCLUSION: Results indicate the suitability of developing new research lines which will optimize the use of HILT.
The identification of preliminary prognostic indicators that predict treatment response for exercise therapy in patients with nonspecific chronic low back pain: A multiple-arm cohort study design
Authors: Denteneer Lenie , Van Daele Ulrike , De Hertogh Willem , Truijen Steven , Deckers Kristiaan , Stassijns Gaetane
Published: January 2020

BACKGROUND: For patients with nonspecific chronic low back pain (CLBP), exercise therapy is stated to be the most effective intervention strategy but it is unclear which kind of exercise therapy is most beneficial. OBJECTIVE: To identify preliminary prognostic indicators that predict outcome for exercise therapy in patients with nonspecific CLBP. METHODS: Patients were recruited in two hospitals and received 18 intervention sessions: stabilization therapy, isometric training therapy or a combination therapy. The primary outcome measure was the change in the Modified Low Back Pain Disability Questionnaire after nine weeks. RESULTS: A total of 59 patients completed the study which represents a statistical power of 90%. In total, 30 patients were categorized as having treatment success and 29 as treatment failure. After using regression analyses to determine the association between standardized examination variables and treatment response status, prognostic indicators were identified for predicting therapy success (positive likelihood ratio [LR], 3.8) and failure (negative LR, 0.19). CONCLUSIONS: The most important variables were the prone instability test, pelvic tilt test, straight leg raise, body weight, visual analogue scale and the short form 36 health survey.
Asthma and Chronic Obstructive Pulmonary Disease as a Comorbidity and Association with the Choice of Antidementia Medication Among Persons with Alzheimer’s Disease
Authors: Lampela Pasi , Tolppanen Anna-Maija , Koponen Marjaana , Tanskanen Antti , Tiihonen Jari , Hartikainen Sirpa , Taipale Heidi
Published: January 2020

Background:

Asthma and chronic obstructive pulmonary disease (COPD) are common comorbidities in persons with Alzheimer’s disease (AD). However, pharmacotherapy of these diseases may have opposite mechanisms of action; anticholinergics in asthma/COPD and acetylcholinesterase inhibitors (AChEI) in AD.

Objective:

To investigate whether existing asthma/COPD affects the choice of AD medication, and the survival of the patients with AD.

Methods:

In this retrospective cohort study, data from the MEDALZ-study, which includes all community-dwelling persons with AD during 2005–2011 in Finland ( n = 70718) was utilized. Persons with asthma/COPD (N = 7211) were defined as having a special reimbursement for asthma/COPD, or long-term use (≥250 days) of inhaled anticholinergics, inhaled corticosteroids, or leukotriene antagonists during the year before AD diagnosis. We compared persons with and without asthma/COPD regarding the choice of the initial antidementia medication (AChEI versus memantine) with logistic regression and mortality with Cox regression model during the follow-up (up to end of 2015).

Results:

Memantine was favored over AChEIs as first-line treatment to AD in persons with asthma/COPD compared to those without asthma/COPD (odds ratio 1.23, 95% confidence interval (CI) 1.15–1.31). Memantine was also more commonly used among those who used multiple asthma/COPD medications (7.9% of memantine initiators used ≥3 asthma/COPD medications compared with 5.5% of those who initiated with AChEI). Mortality was higher in persons with asthma/COPD compared to those without asthma/COPD (adjusted hazard ratio 1.10, 95% CI 1.07–1.13).

Conclusion:

More frequent use of memantine instead of AChEI may result from an attempt to prevent possible worsening of asthma/COPD by AChEIs. Vulnerable persons with both AD and asthma/COPD need individually assessed pharmacotherapy for their medical conditions.
Comparing the Effect of Interference on an Emotional Stroop Task in Older Adults with and without Alzheimer’s Disease
Authors: Meléndez Juan C. , Satorres Encarnación , Oliva Itxasne
Published: January 2020

Background:

Impairments in the ability to recognize facial affective expressions may lead to social dysfunction and difficulties with interpersonal communication.

Objective:

The objective was to compare the attentional responses on a Stroop emotional task using words and faces by testing whether the two stimuli differ in the degree of interference they produce in patients with Alzheimer’s disease (AD).

Methods:

There were 75 participants: 25 healthy older adults, 25 with mild AD, and 25 with moderate AD. A variation of the classic emotional Stroop test was administered. This task combined emotional words (happy or sad) superimposed on facial expressions (happy or sad), where the words were either incongruent or congruent with the emotion expressed by the face stimuli.

Results:

Facilitation was shown on negative words in healthy older adults, and significant effects were obtained for condition, valence, group, and the condition x group interaction. Although less interference was observed on negative stimuli, the fastest reaction times were found for congruent positive stimuli. The effect of interference in healthy older adults is similar in both conditions. However, in the AD groups, there is less interference on the words task than on the faces task.

Conclusion:

The more complex nature of faces, as opposed to the over-learning and automaticity of words, may explain the higher interference in AD patients in the faces condition. In patients with AD, words can be a better method for recognizing emotions than affective facial expressions.
Association of Hypercholesterolemia with Alzheimer’s Disease Pathology and Cerebral Amyloid Angiopathy
Authors: Xu Chenjia , Apostolova Liana G. , Oblak Adrian L. , Gao Sujuan
Published: January 2020

Background:

Animal studies have shown that diet-induced hypercholesterolemia (HC) increases amyloid-β (Aβ) accumulation and accelerates Alzheimer’s disease (AD) pathology. However, the association of HC with AD in human studies has not been consistently established.

Objective:

We aimed to investigate the relationship between HC and risk of AD neuropathology in a large national sample with autopsies.

Methods:

This study used neuropathological and clinical data from 3,508 subjects from the National Alzheimer’s Coordinating Center (NACC) who underwent autopsies from 2005 to 2017. Demographic and clinical characteristics, as well as neuropathological outcomes were compared between subjects with and without HC. Associations between HC and AD neuropathology were examined by multivariate ordinal logistic regressions adjusting for potential confounders.

Results:

HC was not associated with any AD neuropathology in a model only adjusting for demographic variables. However, HC was significantly associated with higher CERAD neuritic and diffuse plaque burden, higher Braak stage, and more severe cerebral amyloid angiopathy when analyzed in a multivariate model controlling for comorbidities. Additional adjusting for cerebrovascular conditions did not diminish these associations. The association between HC and increased risk of neuritic plaques weakened but remained significant even after controlling for ApoE genotype.

Conclusion:

This study suggested that HC was associated with increased severity of AD pathology, which could only be partially accounted for by ApoE genotype. The associations were not mediated by cerebrovascular conditions.
Neuroimaging in Vascular Cognitive Impairment and Dementia: A Systematic Review
Authors: Frantellizzi Viviana , Pani Arianna , Ricci Maria , Locuratolo Nicoletta , Fattapposta Francesco , De Vincentis Giuseppe
Published: January 2020

Cerebrovascular diseases are well established causes of cognitive impairment. Different etiologic entities, such as vascular dementia (VaD), vascular cognitive impairment, subcortical (ischemic) VaD, and vascular cognitive disorder, are included in the umbrella definition of vascular cognitive impairment and dementia (VCID). Because of the variability of VCID clinical presentation, there is no agreement on criteria defining the neuropathological threshold of this disorder. In fact, VCID is characterized by cerebral hemodynamic alteration which ranges from decreased cerebral blood flow to small vessels disease and involves a multifactorial process that leads to demyelination and gliosis, including blood-brain barrier disruption, hypoxia, and hypoperfusion, oxidative stress, neuroinflammation and alteration on neurovascular unit coupling, cerebral microbleeds, or superficial siderosis. Numerous criteria for the definition of VaD have been described: the National Institute of Neurological Disorders and Stroke Association Internationale pour Recherche'-et-l’Enseignement en Neurosciences criteria, the State of California Alzheimer’s Disease Diagnostic and Treatment Centers criteria, DSM-V criteria, the Diagnostic Criteria for Vascular Cognitive Disorders (a VASCOG Statement), and Vascular Impairment of Cognition Classification Consensus Study. Neuroimaging is fundamental for definition and diagnosis of VCID and should be used to assess the extent, location, and type of vascular lesions. MRI is the most sensible technique, especially if used according to standardized protocols, even if CT plays an important role in several conditions. Functional neuroimaging, in particular functional MRI and PET, may facilitate differential diagnosis among different forms of dementia. This systematic review aims to explore the state of the art and future perspective of non-invasive diagnostics of VCID.
Functional Connectivity of Default Mode Network Subsystems in the Presymptomatic Stage of Autosomal Dominant Alzheimer’s Disease
Authors: Zhao Tan , Quan Meina , Jia Jianping
Published: January 2020

Background:

The default mode network (DMN) could be divided into subsystems, the functional connectivity of which are different across the Alzheimer’s disease (AD) spectrum. However, the functional connectivity patterns within the subsystems are unknown in presymptomatic autosomal dominant AD (ADAD).

Objective:

To investigate functional connectivity patterns within the subsystems of the DMN in presymptomatic subjects carrying PSEN1, PSEN2, or APP gene mutations.

Methods:

Twenty-six presymptomatic mutation carriers (PMC) and twenty-nine cognitively normal non-carriers as normal controls (NC) from the same families underwent resting state functional MRI and structural MRI. Seed-based analyses were done to obtain functional connectivity of posterior and anterior DMN. For the regions that showed significant connectivity difference between PMC and NC, volumes were extracted and compared between the two groups. Connectivity measures were then correlated with cognitive tests scores.

Results:

The posterior DMN showed connectivity decrease in the PMC group as compared with the NC group, which was primarily the connectivity of left precuneus with right precuneus and superior frontal gyrus; the anterior DMN showed significant connectivity decrease in the PMC group, which was the connectivity of medial frontal gyrus with middle frontal gyrus. In the brain regions showing connectivity changes in the PMC group, there was no group difference in volume. A positive correlation was observed between the precuneus connectivity value and Mini-Mental State Examination total score.

Conclusion:

Functional connectivity within both posterior and anterior DMN were disrupted in the presymptomatic stage of ADAD. Connectivity disruption within the posterior DMN may be useful for early identification of general cognitive decline and a potential imaging biomarker for early diagnosis.
RETRACTED: The role of antibiotics in the preparation of antitumor drugs under fuzzy system
Authors: Yue Changwu , Li Xiaoqian , Zhao Wen , Cui Xiangyi , Wang Yinyin
Published: January 2020

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219320.
Translating concepts of neural repair after stroke: Structural and functional targets for recovery
Authors: Regenhardt Robert W. , Takase Hajime , Lo Eng H. , Lin David J.
Published: January 2020

Stroke is among the most common causes of adult disability worldwide, and its disease burden is shifting towards that of a long-term condition. Therefore, the development of approaches to enhance recovery and augment neural repair after stroke will be critical. Recovery after stroke involves complex interrelated systems of neural repair. There are changes in both structure (at the molecular, cellular, and tissue levels) and function (in terms of excitability, cortical maps, and networks) that occur spontaneously within the brain. Several approaches to augment neural repair through enhancing these changes are under study. These include identifying novel drug targets, implementing rehabilitation strategies, and developing new neurotechnologies. Each of these approaches has its own array of different proposed mechanisms. Current investigation has emphasized both cellular and circuit-based targets in both gray and white matter, including axon sprouting, dendritic branching, neurogenesis, axon preservation, remyelination, blood brain barrier integrity, blockade of extracellular inhibitory signals, alteration of excitability, and promotion of new brain cortical maps and networks. Herein, we review for clinicians recovery after stroke, basic elements of spontaneous neural repair, and ongoing work to augment neural repair. Future study requires alignment of basic, translational, and clinical research. The field continues to grow while becoming more clearly defined. As thrombolysis changed stroke care in the 1990 s and thrombectomy in the 2010 s, the augmentation of neural repair and recovery after stroke may revolutionize care for these patients in the coming decade.
Double-Stranded RNAs in Plant Protection Against Pathogenic Organisms and Viruses in Agriculture
Authors: Morozov S. Y. , Solovyev A. G. , Kalinina N. O. , Taliansky M. E.
Published: January 2020

Recent studies have shown that plants are able to express the artificial genes responsible for the synthesis of double-stranded RNAs (dsRNAs) and hairpin double-stranded RNAs (hpRNAs), as well as uptake and process exogenous dsRNAs and hpRNAs to suppress the gene expression of plant pathogenic viruses, fungi, or insects. Both endogenous and exogenous dsRNAs are processed into small interfering RNAs (siRNAs) that can spread locally and systemically through the plant, enter pathogenic microorganisms, and induce RNA interference-mediated pathogen resistance in plants. There are numerous examples of the development of new biotechnological approaches to plant protection using transgenic plants and exogenous dsRNAs. This review summarizes new data on the use of transgenes and exogenous dsRNAs for the suppression of fungal and insect virulence genes, as well as viruses to increase the resistance of plants to these pathogens. We also analyzed the current ideas about the mechanisms of dsRNA processing and transport in plants.
课程思政背景下高校思政课程学生评价策略研究
Authors: 董 韩博
Published: January 2020

高校思政课程是高校思想政治教育的主渠道,在课程思政改革的背景下,加强高校思政课程建设仍是关键。高校思政课程学生评价对于实现高校思政课程的价值引领具有重要作用,课程思政改革和高校思政课程学生评价有着内在逻辑关系。本文通过对目前高校思想政治课程学生评价现状以及存在的问题进行分析,最后探讨了提升高校思政课程学生评价应用效能的策略。
提升学生资助管理工作育人实效性的路径研究
Authors: 罗 东超 , 黄 敏
Published: January 2020

高等教育肩负着为中国梦的实现培养高素质人才的重任,为了促进教育公平,维护社会和谐稳定,党和国家高度重视对家庭经济困难学生的资助和帮扶。在当前形势下,国家和高校不仅要建立健全我国资助工作体系,帮助困难学子完成学业.更要对受助困难生进行人文关怀、心理疏导和思想引导,充分发挥资助工作的育人实效性。
网络舆情视野下我国高校意识形态管理的强化路径探析
Authors: 李 良田
Published: January 2020

网络舆情视域下,高校意识形态管理在迎来发展契机的同时,面临着艰巨挑战,而高校要想进一步强化意识形态管理,需明确认知高校意识形态受到网络舆情的影响,借助网络舆情优势,通过对高校思政教育的宣传强化,实现对高校意识形态管理强化,确保高校办学方向与社会人才需求相契合。本文针对网络舆情视野下我国高校意识形态管理的强化进行分析研究。
大学生创业项目“聊吧”
Authors: 任 晓玲 , 郭 美杰 , 张 林菲 , 王 迦昕
Published: January 2020

在这个科技繁荣的时代,人们对手机的依赖程度越来越高,低头族现象日趋普遍。为此,本着放下手机、现实交流的理念,我们打算建立一个专门的开怀畅聊的场所——“聊吧”休闲娱乐厅,让大家有一个可以拉近距离、直面心灵的放松而又温馨的环境。无论从多样化的店内设计、具体有效的经营策略,还是从项目开设的餐饮、演艺、树洞、心理治疗等基础及特定增值服务,都彰显着本店别具一格的风格特色以及顾客至上的服务宗旨。最终希望能更好地满足各类消费者需求,进而更稳更快地开放市场。
Prediction of the Solubility of Recovery Boiler Precipitator Ash
Authors: SATURNINO DANIEL , TRAN HONGHI
Published: January 2020

The solubility of recovery boiler precipitator ash in water is important in the design and operation of ash treatment systems used to control chloride (Cl) and potassium (K) accumulation in the kraft recovery cycle. We determined the solubility of mixtures of alkali salts that constitute precipitator ash and several precipitator ash sam-ples, through laboratory experiments and theoretical simulation using a commercially available thermodynamic pro-
gram. The solubility of precipitator ash in water at 85°C varies widely, from 400–550 g/L H2O, depending on ash composition. The composition of the liquid portion of an ash-water slurry changes significantly with an increase in
ash concentration: the Cl concentration increases, the sulfate (SO4) concentration decreases, and the K and carbon-ate (CO3) concentration remain the same. Between 30ºC–100ºC, temperature has little effect on the solubility of pre-cipitator ash and on the composition of the liquid portion of the slurry.
An evaluation of ECT sample height for small flute board grades and Box Manufacturer’s Certification compliance
Authors: WILSON CORY JAY , FRANK BENJAMIN
Published: January 2020

TAPPI test T811 is the specified method to ascertain ECT relative to box manufacturer’s certification compliance of corrugated fiberboard under Rule 41/ Alternate Item 222. T811 test sample heights were derived from typical board constructions at the time of the test method’s initial development. New, smaller flute sizes have since been developed, and the use of lighter weight boards has become more common. The T811 test method includes sample specifications for typical A-flute, B-flute, and C-flute singlewall (and doublewall and triplewall) structures, but not for newer thinner E-flute or F-flute structures. This research explores the relationship of ECT sample height to measured compressive load, in an effort to determine valid E-flute and F-flute ECT sample heights for use with the T811 method. Through this process, it identifies challenges present in our use of current ECT test methods as a measure of intrinsic compressive strength for smaller flute structures. The data does not support the use of TAPPI T 811 for ECT measurement for E and F flute structures, and demonstrates inconsistencies with current height specifi-cations for some lightweight B flute.