bluuebunny/crossref_metadata_2025 huggingface dataset:
Insights into the binding selectivity of harzianoic acids A and B to tetraspanin CD81
Authors: Vergoten Gérard , Bailly Christian
Published: November 2023

Aim: Harzianoic acids A and B (Hz-A/B) are two rare cyclobutene-containing sesquiterpenes isolated from a marine strain of the sponge-associated fungus Trichoderma harzianum. They display anticancer and antiviral effects, reducing the entry of hepatitis C virus (HCV) into hepatocarcinoma cells. The large extracellular loop (LEL) of the tetraspanin protein CD81 represents a molecular target for both Hz-A and Hz-B. Methods: The interaction of Hz-A/B with CD81 has been modeled, using structures of the cholesterol-bound full-length protein and a truncated protein corresponding to the LEL portion. The models mimicked the closed and open conformations of the LEL. Results: The best ligand Hz-B can form stable complexes with the open LEL structure, whereas binding to the closed form is drastically reduced. Key H-bonds between the acid groups of Hz-B and the CD81-LEL domain stabilize the ligand-protein complex. A comparison of the interaction with the homologous tetraspanin CD9, which also presents a dynamic open/closed equilibrium, underlined the marked selectivity of Hz-A/B for CD81 over CD9. The cyclobutane-containing monoterpene grandisol, an insect pheromone, has been identified as a fragment that could be modulated to improve its modest interaction with CD81-LEL. Conclusions: The modeling docking analysis suggests that Hz-B is a robust CD81 binder, better interacting with the LEL portion of CD81 compared to CD9-LEL. The docking study paves the way to the design of small molecules targeting CD81. The study has implications for a better understanding of CD81 binding properties and the regulation of its activities.
A decade of CD4+ chimeric antigen receptor T-cell evolution in two chronic lymphocytic leukemia patients: were chronic lymphocytic leukemia cells present?
Authors: Bouzianas Dimitrios , Bouziana Stella
Published: November 2023

On Feb 2, 2022, Nature published the paper titled “Decade-long leukemia remissions with the persistence of CD4+ CAR T-cells” (Nature. 2022;602:503–9. doi: 10.1038/s41586-021-04390-6). According to the results presented, it could be argued that “chimeric antigen receptor (CAR) T-cells can actually cure patients with chronic lymphocytic leukemia (CLL)”. CAR T-cells remained detectable more than ten years after infusion, and immunoglobulin heavy chain (IGH) rearrangement deep sequencing showed persistent deep molecular remission for both patients (no CLL clonotypes were detectable six months after CAR T-cell infusion and onwards). However, the existing actual disease status of both patients remained unclear, as it was unknown: (1) if CAR T-cells killed all leukemia cells during the initial anti-leukemic response phase, that is, soon after CAR T-cell infusion into both patients; (2) if few CLL cells survived, but persistent CAR T-cells had been able to destroy any leukemia cells before they reach detectable levels. In the first case, both patients could be considered definitely cured; in the second not and their decade-prolonged deep remission could be a consequence of the cytotoxic activity of the functionally active CD4+ CAR T-cells. The first version appears to be stronger and the supporting arguments have been included in a comprehensive commentary article. A new therapeutic intervention may emerge with the potential to fully improve the quality of life of both patients and in addition, ongoing research into CAR T-cells may turn in a new, more effective direction.
Análisis correlacional del razonamiento lógico abstracto y deductivo con el rendimiento académico en general y en el área matemática
Authors: Vázquez Espinosa Eliel , Cahuich Cahuich Tomás Felipe
Published: November 2023

En la enseñanza de las matemáticas influyen diferentes variables y se espera que después de completar los ciclos de formación en matemáticas los alumnos tengan diferentes habilidades útiles para la vida diaria. Si com- prendemos tanto lo que influye en la enseñanza como lo que se consigue verdaderamente con ella podremos mejorar las clases de matemáticas. Basado en otros instrumentos, se diseñó uno que intenta medir el razonamiento lógico con base en la habilidad deductiva y la capacidad de abstracción. El estudio se realizó con una muestra correspondiente a licenciaturas con enfoque en la enseñanza, en una escuela privada del norte de México, con una edad promedio de 21 años. Se encontró que el razonamiento lógico no tiene correlación con el rendimiento académico general (ρ = .262, p = .061) pero sí con el rendimiento académico matemático (ρ = .303, p = .041). Esta última correlación lineal resultó positiva y nos indica que al aumentar el razonamiento lógico aumenta el rendimiento académico en matemáticas y, al disminuir una de ellas, la otra también.
Factores predictores del desempeño laboral en un grupo de docentes de escuelas mexicanas privadas
Authors: Sánchez Pacheco Primitivo , Muñoz Palomeque Manuel
Published: November 2023

La presente investigación tuvo como objetivo conocer si el grado de moti- vación laboral, el grado de capacitación, el grado de cumplimiento de la misión institucional, el grado de práctica religiosa y el grado de satisfacción laboral son predictores del desempeño laboral autopercibido por los docentes participantes en el estudio. La muestra estuvo conformada por 145 docentes de instituciones educativas privadas de varios estados mexicanos. Para el análisis, se utilizó la re- gresión lineal múltiple por pasos sucesivos. Se encontró que el predictor más fuer- te fue la motivación laboral que explica el 69.9% de la varianza del desempeño laboral. En un segundo paso, se encontró que dos de las variables —motivación laboral y capacitación— constituyen importantes predictores del desempeño la- boral; juntas explican un 74.5% de su varianza. Con base en lo anterior, se afirma que, en la medida en que los docentes de la población estudiada mejoren su grado de motivación laboral y reciban un mayor grado de capacitación, mejorará la calidad de su desempeño.
Perencanaan Jalur Kereta Api Lintas Kamal-Suramadu Dengan Global Mapper dan Autocad Civil 3dD
Authors: Wiarco Yuwono , Aghastya Adya
Published: November 2023

Pengembangan jaringan perkeretaapian di Madura berupa reaktivasi jalur lama dan pembangunan jalur baru, seperti yang tercantum pada Rencana Induk Perkeretaapian Nasional (RIPNas) dan KP No. 2128 Tahun 2018. Penelitian ini akan berfokus pada perencanaan reaktivasi jalur kereta api lintas Kamal-Bangkalan-Suramadu, dengan tujuan untuk mendorong pembangunan jalan rel di Pulau Madura, yang dapat meningkatkan perekonomian dan mobilitas Masyarakat Madura. Perencananaan jalan rel Kamal-Suramadu akan mengacu pada PM no. 11 tahun 2012 dan PM no 60 tahun 2012, serta dengan menggunakan software Global Mapper dan Civil 3D. Sebagian besar dari jalur kereta api eksisting di Bangkalan-Kamal telah dimanfaatkan sebagai pemukiman atau pemerintahan yang padat penduduk (54%), pemukiman dengan kepadatan sedang (24%), dan lahan persawahan atau lahan kosong (22%). Jalur kereta api eksisting menggunakan single track dengan lebar spoor 1067mm dan rel jenis R25. Trase terpilih adalah alternatif trase ke 2 dengan panjang 31.152 meter dan membutuhkan lahan seluas 566.266 m2 untuk pembangunannya. Perencanaan alinyemen horizontal menghasilkan 7 lengkung horizontal dengan radius 1100 m (lengkung 1, 2, dan 7), 800 m (lengkung 3 dan 5), dan 950 m (lengkung 4 dan 6). Pekerjaan galian dan timbunan dengan volume kumulatif galian tanah sebesar 2.399.262,85 m3, dan volume kumulatif timbunan tanah sebesar 891.563,7 m3. Komponen jalan rel yang dibutuhkan mencakup 51,921 buah bantalan beton, 207.684 buah penambat pendrol e-clip, 2.493 batang rel R54, 48.286 m3 balas, dan 59.812 m3 subbalas.
On the Optimal Choice of Type of Combustion Chamber for the Initiation of Gas Detonation
Authors: Voronin D. V.
Published: November 2023

A numerical simulation of continuous gas detonation in the combustion chamber based on the Navier-Stokes equations, taking into account turbulence and diffusion of substances, is carried out. A comparative analysis of the efficiency of detonation combustion of fuel depending on the geometric parameters of the chambers is performed. Three possible camera types are considered. Fuel and oxidizer were fed separately into the chambers through nozzles at a certain angle to the chamber surface. The detonation process was largely determined by the intensity of the turbulent mixing of reagents (hydrogen and oxygen). Calculations show that the type of camera with a flat radial geometry is the most optimal to establish a stable detonation regime.
Best Practice Guidelines on the Ansys in Building Wind Action Applications
Authors: Teixeira Guilherme S. , De Campos Marco D.
Published: November 2023

In the last 30 years, Computational Fluid Dynamics use in Wind Engineering has allowed researchers to raise its capabilities, and, little by little, it is becoming a reasonable tool because of the availability of high‐performance computers with large storage capacities. This work offers a short guide to the twelve tips computer beginners can take on the Ansys in building wind action applications.
Validity evidence based on content: Controversies and quantification
Authors: Santoso Agung , Savira Alice Whita , Prihatmoko Robertus Landung Eko
Published: November 2023

Validity is a crucial issue in test development because it represents the accuracy of test score interpretation in describing the measured attribute or construct. Among validity evidence that can be collected to support test score interpretation, the one based on test content incited controversies. The content-based validity evidence includes analyses of the relationship between test content and the construct the test purported to measure. Some authors opposed the use of such evidence in the validation process, arguing that the evidence can only provide hypotheses to be tested in the subsequent processes. Other authors argued that the content validation process provided meaningful information regarding test validity, particularly tests based on content such as achievement tests. Unfortunately, literature regarding such issues hitherto has not addressed the controversies adequately. Furthermore, several techniques for quantifying the content-based validity evidence have been proposed without any other article reviewing and evaluating them in comparison with the others. The current study was conducted to examine propositions made by prominent authors regarding validity based on test content and to compare proposed quantification techniques.
A formative evaluation of the program for student representatives in a university discipline panel
Authors: Layag Diana Genevieve
Published: November 2023

The university employs a representation of different sectors in the academic community when dealing with major student conduct violations. Among them is the representative of the students. At the time of the study, the student representatives were qualified students who were recruited and trained to become part of the university discipline case conference panel. Upon successful completion of the training, these students were appointed to be members of a program for the pool of student representatives who sit as part of the university adjudicating body, which makes decisions for the university student discipline cases. Terminally, the researcher wanted to improve the engagement and retention of these trained students in the program. Thus, the purpose of conducting this study was to explore the experiences of the students in handling their first case of student conduct violation as part of the university discipline panel. This utilized qualitative methodology in conducting a formative evaluation of the program. Students were asked to submit written reflections on the first student conduct case that they handled. Of the 19 student representatives, eight participated in this study. Line-by-line analysis was done to develop the themes. The findings of this study were four themes that surfaced from the students’ experiences: competence, decision-making, vicarious learning, and emotions. This study supports previous research on the importance of supportive adult relationships, which positively impact young people’s engagement, as well as the involvement of students in the disciplinary process.
Validation of the Child and Adult Social Support Scale (CASSS) which measures social support in the Indonesian version
Authors: Mastuti Endah , Fajrianthi  , Andriani Fitri
Published: November 2023

Social support has an important role, so that students in online learning can reduce the various problems they face. Social support here comes from parents, teachers, classmates, close friends, and the school itself as an institution. Based on this, it is necessary to do research related to social support to get an overview of the support from whom students need in online learning. Furthermore, this can be used as input to intervene in the problems faced by students. To conduct this research, it is necessary to have a measuring tool to conduct social support research. One of the comprehensive measuring tools in measuring social support is the Child and Adult Social Support Scale (CASSS) which has been made by (Malecki & Demaray, 2002). This study aims to: (1) adapt the Indonesian version of the CASSS measuring instrument, (2) test the psychometric properties of the measuring instrument that has been adapted in Indonesian. The results show that the CASSS measuring instrument that has been adapted shows that the loading factor value of all items is above 0.7. Based on this, it can be said that all items (60 items) in the CASSS scale which are the observed variables have good validity on the latent variables on each dimension of the Social support construct. Meanwhile, each dimension also has a good factor load on the Social Support construct. This shows that all CASSS items have good validity values so that they can be used for further research. The results of the reliability calculation show that all subscales of the CASSS Scale have a reliability value above 0.9 using the alpha technique.
Impacto del Semillero en Ciencia e Ingeniería en Alumnos del Nivel Medio Superior
Authors: Aguilar Covarrubias Norma Araceli , Hernández Córdova Adriana , Martínez García Ruth Margarita
Published: November 2023

Este trabajo expone los hallazgos del “semillero en ciencia e ingeniería, talleres de hoja de cálculo y programación, el cálculo diferencial a través de la experimentación y principios de soldadura”, en el nivel medio superior. Con la finalidad de establecer un espacio pedagógico de reflexión y practica entre alumnos y docentes retomando conocimientos sobre ciencia, ingeniería, útiles en el contexto formativo de los alumnos, desarrollando habilidades y destrezas mediante talleres conformados por exposiciones teóricas-prácticas. El tipo de estudio fue un enfoque investigativo cuantitativo y cualitativo, con el método de investigación descriptivo-exploratorio y un diseño no experimental transeccional. Para el análisis de datos se usó la estadística descriptiva, frecuencias y porcentajes. Los resultados demuestran el impacto del proyecto, supero las expectativas dado que los alumnos señalaron sus aspiraciones a continuar su preparación profesional en la educación superior, el semillero les fue interesante, educativo, útil y con utilización en los trabajos y proyectos de sus materias consecuentes, entre otros. Para finalizar, se encontró que la propuesta tuvo un impacto significativo, al fomentar conocimientos de ciencia e ingeniería a estudiantes del nivel medio superior, generando un posicionamiento de construcción cognitiva, en la búsqueda de una mejor preparación para su incursión al nivel superior.
Enfermedad de Lyme en Paciente Masculino con Antecedentes De Microadenoma Hipofisiario y Síndrome de Kallman. Reporte de Caso
Authors: Bailón Pinargote Franklin Daniel , Alejandro Torres Pablo Xavier , Vargas Ramón Mayra Mercedes , Camacho Muñoz John Roberto , Núñez Chariguamám Manuel Alejandro
Published: November 2023

La enfermedad de Lyme es una zoonosis causada por la espiroqueta Borrelia burgdorferi, la cual es transmitida por garrapatas, es una infección propia de animales que puede ser transmitida a personas, esto es lo que se conoce como zoonosis. Se trata de una enfermedad que sin el tratamiento adecuado se cronifica y en la que se suele establecer un orden cronológico en la evolución. Tras un periodo de incubación de 3 a 32 días aparecen los síntomas del estadio I o fase precoz localizada. El signo inicial característico es el Eritema migrans, lesión cutánea tras la inoculación que puede pasar desapercibida y suele acompañarse de un síndrome pseudogripal. Se Reporta el caso de un paciente masculino de 20 años con antecedentes de importancia, Microadenoma hipofisiario y síndrome de kallman acude por referir eritema en miembros superiores e inferiores, seguidos de alza térmica no cuantificada acompañada de malestar general motivo por el cual acude a emergencias.
Sosialisasi Kelompok Asuhan Mandiri Delima 5 Dan Manfaat Tanaman Toga dan Akupresur
Authors: Pramesti Renika , Mudifah Sudevi , Situmeang Ilona Vicenovie Oisina , Meisyanti Meisyanti
Published: November 2023

Kegiatan sosialisasi ini dilakukan oleh Tim Pengabdian Kepada Masyarakat Universitas Persada Indonesia YAI beserta dengan mahasiswa MBKM bekerjasama dengan kelompok Asuhan Mandiri (ASMAN) Delima 5 Malaka Sari. Sosialisasi ini dilakukan karena terdapat permasalahan yaitu kurangnya sumber daya manusia pada Kelompok ASMAN Delima 5, minimnya pengetahuan anggota tentang manfaat setiap jenis tanaman obat keluarga dan masih sulitnya melakukan praktik terapi akupresur. Hasil dari kegiatan sosialisasi ini adalah masyarakat dapat memahami dan mengetahui pentingnya tanaman obat keluarga, membuat masyarakat menjadi lebih paham terkait penggunaan teknik akupresur, dan kegiatan sosialisasi ini juga membantu Kelompok ASMAN Delima 5 dalam memperkenalkan kelompok serta kegiatan dari ASMAN Delima 5 ini, dan diketahui bahwa terdapat masyarakat yang tertarik untuk bergabung dengan ASMAN Delima 5

This socialization activity was carried out by the University of Persada Indonesia YAI Community Service Team along with MBKM students in collaboration with the ASMAN Delima 5 Malaka Sari group. This socialization was carried out because there were problems, namely the lack of human resources in the ASMAN Delima 5 Group, the members' lack of knowledge about the benefits of each type of family medicinal plant, and the difficulty of practicing acupressure therapy. The results of this socialization activity are that people can understand and know the importance of family medicinal plants and become more aware of the use of acupressure techniques. This socialization activity also helps the ASMAN Delima 5 Group introduce groups and activities from ASMAN Delima 5, and it is known that there are people who are interested in joining ASMAN Delima 5
Penerapan Teknologi, Perbaikan Aspek Hukum dan Manajemen pada BUMDes “Cipta Baraya Mandiri
Authors: Khaerudin Dedy , Saefullah Encep , Asnawi Asnawi , Fatari Fatari
Published: November 2023

Mitra Pemberdayaan Kemitraan Masyarakat (PKM) ini adalah Pemerintah Desa Padarincang dan pengelola BUMDes “Cipta Baraya Mandiri”. Tujuan PKM ini diselaraskan dengan permasalahan mitra yakni: 1) Untuk meningkatkan penerapan dan penggunaan teknologi dalam pengelolaan unit usaha BUMDes, (2) Untuk meningkatkan pengetahuan dan keterampilan mitra dalam pengelolaan manajemen usaha yang baik dan benar melalui penerapan Ipteks, (3) Untuk pendampingan hukum berkaitan dengan legalitas hukum BUMDes dan untuk meningkatkan pemahaman hukum, dan (4) Untuk meningkatkan peran BUMDes dalam pemberdayaan ekonomi masyarakat, sehingga kesejahteraan masyarakat turut meningkat. Untuk mencapai tujuan tersebut tim pengabdi menyusun rencana kegiatan yang meliputi 4 (empat) tahap, yaitu tahap 1 analisis situasi dan kondisi mitra, tahap 2 persiapan dan transfer Ipteks, tahap 3 pelatihan dan pendampingan dan tahap 4 evaluasi dan keberlanjutan program. Kegiatan ini menghasilkan peningkatan Pengetahuan dan Pemahaman Hukum, peningkatan Pengetahuan dan Keterampilan mitra tentang pengelolaan Manajemen dan penggunaan teknologi sebesar 82,18%.

This Community Partnership Empowerment Partner (PKM) is the Padarincang Village Government and the manager of the "Cipta Baraya Mandiri" BUMDes. The objectives of this PKM are aligned with partner problems, namely: 1) To increase the application and use of technology in managing BUMDes business units, (2) To increase partners' knowledge and skills in managing good and correct business management through the application of science and technology, (3) For legal assistance relating to the legality of BUMDes and to increase legal understanding, and (4) To increase the role of BUMDes in empowering the community's economy, so that community welfare also increases. To achieve this goal, the service team prepared an activity plan which included 4 (four) stages, namely stage 1 analysis of the partner's situation and condition, stage 2 of preparation and transfer of science and technology, stage 3 of training and mentoring and stage 4 of program evaluation and sustainability. This activity resulted in an increase in Knowledge and Understanding of Law, an increase in Partner Knowledge and Skills regarding management and the use of technology by 82.18%.
Manajemen Pelatihan Pelangi Shibori di SMK Madinatul Ilmi Pantai Mekar Kecamatan Muara Gembong Bekasi
Authors: Suliyanthini Dewi , Noerharyono Muchamad
Published: November 2023

Tujuan kegiatan tridarma Perguruan Tinggi adalah pengabdian masyarakat, dengan memberikan pelatihan membuat produk T-Shirt Pelangi Shibori agar masyarakat dan guru-guru di SMK Madinatul Ilmi memiliki pengetahuan dan keterampilan membuat produk shibori. Responden kegiatan pengabdian ini adalah guru dan masyarakat desa Pantai Mekar Kecamatan Muara Gembong. Hasil kegiatan manajemen pelatihan ini dimulai dari pemberian instrument pre-test,hasil rata-rata 0,3 error peserta belum memahami pengetahuan materi shobori. Tahap selanjutnya pemberian T-shirt putih polos dan kain Cotton putih polos, pengarahan materi mengenai proses, teknis dan cara ketentuan pencelupan, zat warna serta jenis tekstil yang digunakan, melipat kain, proses pelarutan zat warna, dan proses fiksasi zat warna. Pada akhir kegiatan dilakukan post test dengan hasil 100% seluruh peserta telah memahami proses shibori dengan nilai Kepuasan peserta 93% sangat puas pada penyajian pengarahan kegiatan ini.

Community service activity were teachers and the people of Pantai Mekar Village, Muara Gembong District. The results of this training management activity started from giving the pre-test instrument, the average result was 0.3 errors, the participants did not understand the shobori material knowledge. The next stage was the provision of plain white T-shirts and plain white cotton cloth, briefing material on the process, technicalities and procedures for dyeing, dyestuffs and types of textiles used, fabric folding, dye dissolving process, and dye fixation process. At the end of the activity, a post test was carried out with 100% results, all participants understood the shibori process with a participant satisfaction value of 93%, very satisfied with the presentation of this activity briefin
Démons et merveilles : la Shoah au risque de l’imaginaire dans les romans contemporains pour adolescents
Authors: Bazin Laurent
Published: November 2023

Laurent Bazin formule l’hypothèse que les fictions de l’imaginaire constituent une façon somme toute recevable d’aborder un moment de l’histoire impossible à appréhender – justement parce qu’elles constituent la réponse naturelle recherchée par une génération éminemment sensible aux crises existentielles et aux blocages de la communication. Il avance l’idée que la littérature contemporaine pour adolescents produit les conditions d’une relation renouvelée au passé, en assumant le risque de l’invraisemblance pour mieux sensibiliser ses lecteurs, eux-mêmes en situation d’existence problématique, à l’impensabilité de l’Histoire.
À la recherche des corps perdus. Témoins, témoignages et traumatismes dans Billydéki
Authors: Talebian Sedehi Kamelia
Published: November 2023

Au Canada, le dernier pensionnat pour jeunes Aborigènes a fermé ses portes en 1996, mais ses persécutions poursuivent les survivants et leurs descendants. Les œuvres littéraires ont le pouvoir d’informer le public des dérives du passé. Elles mêlent histoire et narrativisation pour faire de la littérature une forme de narration de témoignage capable de présenter les incidents historiques sous un jour nouveau. Les témoignages littéraires transforment ainsi l’histoire des pensionnats canadiens. Billydéki (2019), de Sonia Perron, est un témoignage littéraire des réalités des pensionnats canadiens, mais aussi un parfait exemple de la relation transformationnelle qui lie l’histoire et la narration. Billydéki laisse transparaître les exactions des pensionnats envers les communautés aborigènes. En traduisant en mots l’expérience directe de témoins oculaires, l’autrice historicise ces incidents et abus. La narration ne se contente pas de raconter l’histoire, de dire « voilà ce qu’il s’est passé » ; elle le montre à travers les yeux de divers acteurs ou spectateurs présents au moment du traumatisme. L’objet de cet article est d’appliquer le concept du traumatisme de Judith Herman et le concept de témoignage et de témoin de Shoshana Felman et Dori Laub au roman Billydéki, de Sonia Perron, afin de mettre en lumière les incidents historiques survenus dans certains pensionnats et longuement passés sous silence.
Studies of Some Techniques for Conservation of Forest and Wildlife
Authors: Ahirwar Ram Manoher
Published: November 2023

Forests are large areas of land with trees. Overall, forests are the natural habitat of large-scale wildlife, growth of trees, shrubs, and different varieties of plants which, unfortunately, are dwindling every year. Hence, conservation of forest is an important responsibility that all of us must undertake. Almost 31% of the earth's land surface is covered by forests. According to a 2015 report, 23% of India's land cover consists of the forest region. Trees and plants in the forest are an integral part of the ecosystem. It sustains life on the planet, provides clean air and shelter. Also, forests help conserve biodiversity. Apart from keeping a check on the global temperature, forests also contribute towards preventing soil from getting eroded and sheltering more than 80% of the animal species and terrestrial biodiversity. They also aid in improving the socioeconomic aspects of a country. Wildlife refers to the animal species that are not domesticated. So, any living organism that lives in the forest region is associated with wildlife.
Digital Educational Games
Authors: Delgado Catarina , Mendes Fátima , Brocardo Joana , Boavida Ana Maria
Published: November 2023

This chapter reflects on the challenges that arise when it is intended that all students can experience an Education 5.0 and proposes a set of practical actions that may support teachers' educational practice. It analyses and discusses a study involving 18 primary teachers and their 358 students (ages 6-10), which informed specific adjustments in some educational technological games about mathematics and confirmed, or not, several of the potentialities that intentionally underlined their design. The analysis focused on some problematic aspects related to moving towards an Education 5.0, which allows the integration of digital technologies in a more meaningful way in the learning process, aiming at the development of critical and creative thinking and collaborative work. Finally, suggestions are systematized about the development of quality educational technological tools and teacher training.
Moving Towards Internet of Behaviors
Authors: Kose Busra Ozdenizci
Published: November 2023

The Internet of Behaviors (IoB) is an emerging trend that aims to revolutionize human interactions by analyzing and influencing behavior using data from connected devices. This study explores the importance of blockchain technology in addressing the IoB challenges and enhancing the security and privacy of IoB business models. Blockchain technology provides a decentralized and transparent platform for behavioral data storage and sharing, mitigating privacy concerns. Individuals are empowered with control over their personal data through smart contracts and decentralized identifiers, enabling them to decide how their data is accessed and used within IoB systems. In this study, significant blockchain-based solutions and approaches are presented that can enhance IoB business models through examples. Exploration of blockchain potential in IoB systems will ensure new insights for further advancement and evolution of the IoB paradigm.
Stylometry-Based Authorship Identification
Authors: Pham Duc Huu
Published: November 2023

The Internet has helped to collect and exchange information and data with its constant expansion and evolution for devices to be intertwined with each other. These advances provide invaluable information about people and issues related to their lives including behaviors, interests, and preferences which have brought about the Internet of Behaviors (IoB) in attempts to understand the data collected from users' online activities. From a behavioral psychology perspective, the IoB can address the question of how to understand the data, and how to apply that understanding to create things that benefit humans. The IoB is related to many fields of research including technology, data analytics, and behavior science in relationship with stylometry. The applications of stylometry within the IoB framework such as analyzing the writing style of social media posts, online reviews, journal articles, or literary works at tertiary educational organizations could provide insights into the personality or motivations of the author. Thus, stylometry could potentially be used to identify authorship.
Digital Badges for Stealth Assessment
Authors: Fanfarelli Joey R.
Published: November 2023

This chapter integrates stealth assessment, evidence-centered design, and digital badging research to examine how the stealth assessment process can benefit from the integration of digital badges. It examines design considerations for how badges can be used to interpret and restructure evidence in line with the competency model to create a more user-friendly way to communicate assessment results to both instructors and learners. The task model is related to goal setting to show how digital badges can be used to direct players toward the specific tasks of interest to improve the validity of competency models. The chapter concludes by investigating how these considerations can influence a more complete personalized learning system that implements frequent stealth assessment with digital badges.
Electronic Loyalty of Islamic Banks in Saudi Arabia
Authors: Alsheikh Layla Hodaed
Published: November 2023

This paper aims to explore the impact of electronic customer relationship management practices (website quality, ease of use, customer privacy, and information quality) on the customer electronic loyalty. The population of this study is customers of the Islamic banks in Saudi Arabia. The questionnaire is used as a basic tool in the survey related to the current research. The hypothesized structural equation model was tested using the AMOS software version 20. The study has found that with respect to the bank customers, e-CRM has a significant impact on electronic customer loyalty. Based on the results of the study, bank managers and decision makers should focus more on the optimal distribution of the available resources and strengthening their electronic relationship with customers in order to attract more customers, retain existing customers, and get rid of less profitable customers.
An Obituary for Morten Levin
Authors: Eikeland Olav , Greenwood Davydd J. , Klev Roger , Martin Ann W. , Ravn Johan E.
Published: November 2023

In this text we pay our respects, both professionally and personally, to Morten Levin who passed away this last April 9th, at 76 years of age. We who write this knew Morten from different periods, professional, and geographical distances. Our common ground is our mutual interest in action research and work life research and change, concerns that occupied Morten for decades.

We who write this are:  Roger Klev, Davydd Greenwood, Ann Martin, Johan Ravn, and Olav Eikeland, all engaged, as Morten was, in practices related to work life, action research, and relevant educational and extension programs at Masters and PhD-levels. These are the threads that brought us into Morten´s orbit. 

We each have stories to tell that illuminate Morten’s life and contributions, and this shapes the narrative of our tribute.  Following a summary of his career, we offer our separate accounts of Morten’s gifts to us and his extraordinary professional accomplishments.
Efectividad de Facilitadores del Uso de Dispositivos Tecnológicos en Tareas de Estimulación Cognitiva en Adultos Mayores
Authors: López Moreno María Celeste , Nicotra María Georgina , Malén Rotta Ana Malén , Revollo Sarmiento Elsa Araceli , Roumec Bettina , Vivas Jorge Ricardo , Vivas Leticia Yanina
Published: November 2023

El objetivo fue estudiar la efectividad de algunos facilitadores de uso en un laboratorio web interactivo multipropósito de estimulación cognitiva para personas mayores. Participaron 60 personas mayores divididas en tres grupos pareados: Experimental, Control Activo y Control Pasivo. Cada participante fue evaluado al principio y al final. Se extrajeron seis medidas de desempeño. Un ANOVA de medidas repetidas indicó que hubo mejoras entre el primer y el segundo momento de evaluación en todos los grupos para todas las medidas, salvo para el tiempo empleado. También hubo una interacción entre el cambio pre-post test y la pertenencia al Grupo en: precisión para llegar al ejercicio y número de intentos para finalizar el ejercicio, a favor del Grupo Experimental. Estos resultados indican que, si bien los y las participantes mejoraron en el desempeño con solo ingresar repetidas veces, el uso de las herramientas de facilitación resultó útil mejorando aún más el grupo experimental en ciertos aspectos de la tarea.
SISTEM MONITORING KUALITAS UDARA DI KAWASAN INDUSTRI DENGAN NODEMCU ESP32 BERBASIS IOT
Authors: Harpad Bartolomius , Salmon Salmon , Saputra Rizky Meizal
Published: November 2023

Penelitian ini dilakukan untuk dapat membuat sistem untuk memonitoring kualitas udara seperti CO, NO2 dan H2S yang ada disekitar kawasan industri yang terhubung dengan web dengan output berupa informasi yang ditampilkan di LCD dan website serta memberikan peringatan berupa buzzer yang ada di alat sistem monitoring tersebut. Nantinya penelitian ini dapat membantu industri monitoring kualitas udara di kawasannya.

Penelitian ini dilakukanBalai Riset dan Standardisasi Industri Samarinda (Baristand Industri Samarinda)yang berlokasi di di Jalan MT. Haryono / Banggeris No. 1, Kota Samarinda,Kalimantan Timur.Metode pengumpulan data yang digunakan yaitu dengan wawancara yang mengajukan pertanyaan-pertanyaan serta dengan cara observasi, yaitu mengadakan pengamatan secara langsung ke kantor dandalam penelitian ini metode pengembangan sistem yang digunakan yaitu Prototype.
Thiazide and thiazide-like diuretics associated with improved cardiovascular and renal outcomes for chronic kidney disease patients
Authors: Lin Hugo , Chang Yu-Han , Wang Yu-Tsang , Liang Peir-In , Hung Chi-Chih , Chang Jer-Ming , Dai Dao-Fu , Lin Chang-Shen , Chang Kai-Ting
Published: November 2023

Taiwan

Introduction: Hypervolemia is a prevalent comorbidity of chronic kidney disease (CKD) patients. Thiazide diuretics (THZ) are the most common treatment for volume overload and hypertension (HTN). This study examines the association between THZ usage and clinical outcomes among CKD patients in a nationwide cohort.

Method: The total number of patients in the study was 24,312. After matching with one non-user randomly selected from the CKD population, we identified 8501 patients in the THZ and the comparison cohorts. Cox proportional hazards regression analysis was conducted to estimate the associations of THZ on the incidence of all-cause mortality, end-stage renal disease (ESRD), congestive heart failure (CHF), acute myocardial infarction (AMI), peripheral arterial occlusive disease (PAOD), and stroke.

Results: The all-cause mortality rate was significantly lower in THZ users than in non-users (hazard ratio [HR] = 0.65, 95% confidence interval [CI] = 0.60–0.71). The THZ usage was associated with a lower incidence of ESRD, AMI, PAOD, and stroke (P<0.05). In subgroup analysis, some significant clinical outcomes were related with CKD stages 3 and 4 (P<0.05); however, there were no clinical associations in CKD stage 5. In further THZ subtype analysis, there were clinical associations with fewer deaths, ESRD, AMI, and PAOD accompanying chlorthalidone treatment. Moreover, the indapamide prescription was linked to lower mortality, ESRD, AMI, and PAOD prevalence. However, there were significantly greater incidences of ESRD, CHF, and AMI in the metolazone users.

Conclusion: THZ usage is associated with lower mortality and incidence of ESRD, AMI, PAOD, and stroke s in patients with CKD stages 3 and 4.
How does current paediatrics residency selection criteria correlate with residency performance?
Authors: Teo Jia Hui , Chow Cristelle
Published: November 2023

The selection process for potential residents needs to be reviewed regularly and assessed if effective in selecting the best-fit residents who can achieve academic and professional excellence. Objective measures must take precedence over subjective criteria to reduce selection bias while ensuring transparency and accountability. However, the predictors of an ideal resident and his/her performance during residency training have been a great challenge to identify as part of the selection process. The use of examination results from medical school examination, licensing examinations such as the United States Medical Licensing Examination,1,2,3 and structured interviews4 was reported to correlate positively with doctor’s performances. A Canadian study also reported that the presence of scholarly activity did not affect match outcome, though this is variable for different programmes.5 Competitive programmes like paediatrics have a vested interest in selecting the most suitable applicants who will excel as paediatric residents and emerge as holistic, high-performing paediatricians in their field.6
Four Years Experience with 1940NM Diode Laser and Total EVLA Method. Short Term Outcomes
Authors:   Baltic Vein Clinic, Krisjana Barona Street 115, Riga, Latvia, LV-1012, Udris Ints
Published: November 2023

Background: The use of endovenous laser ablation (EVLA) combined with other techniques, typically miniphlebectomy, is recommended to avoid undesirable complications. We decided to compare the safety and efficacy of two treatment methods – EVLA and the new breakthrough TOTAL EVLA (side brunches and perforator veins are closed by laser) and to investigate whether the TOTAL EVLA is associated with a lower complication risk.
Passive smoking and the health of children: a primary concern in Pakistan
Authors: Jafri Syeda Fatima Mehdi , Syeda Fizza Hussain  , Wajiha Zehra
Published: November 2023

Dear Madam,
Environmental tobacco smoke (ETS), also referred to as second-hand, involuntary, or passive smoke, is produced from the combustion of tobacco products or puffed out by active smokers. The smoke emitted from the tip of a cigarette contains about two times the concentration of nicotine, five times the concentration of Carbon monoxide, and 50 times the concentration of ammonia than active smoke1. Furthermore, amongst the exposed population, children are far more susceptible to complications associated with ETS due to their manner of exposure and developmental physiology. According to the 2014 Global Adult Tobacco Survey for Pakistan, 43.3% of households were exposed to ETS, with a significant amount of children included in that percentage2. Thus, children's health is more detrimentally impacted by ETS than adults.
Exposure of children to ETS in domestic and public settings risks a higher occurrence of respiratory and middle-ear diseases. According to numerous studies, dose-dependent exposure to ETS directs more frequent and severe asthma attacks accompanied by wheezing. Moreover, it is observed that school-aged individuals who live in a smoking household tend to develop a range of lung diseases, including bronchitis, bronchiolitis, and pneumonia. Their lungs become weak, resulting in impaired pulmonary function3. With reference to a population-based cohort study conducted by Lovasi et al. (ref 4), it was evident that childhood ETS exposure from 2 or more smokers compared with none is linked with early emphysema in adulthood4. In addition, constant ETS exposure leads to swelling and obstruction of the eustachian tube, which interferes with pressure equalization leading to pain, fluid accumulation, and infection. Ear infections and middle ear fluid are the most common causes of hearing loss in children.
Being the primary reason behind several disease, ETS is also known to cause acute effects on cardiovascular function in children. Compelling evidence demonstrates that childhood ETS exposure risks the accumulation of factors associated with cardiovascular diseases, including obesity, dyslipidemia, and imbalanced systolic and diastolic blood pressure5. [Exposure to hazardous chemicals found in ETS, for instance, benzopyrene, is known to accelerate the development of atherosclerosis].  Moreover, studies show convincing evidence that hypertension is common in children exposed to ETS at home. It is also observed that hypertension is a common risk factor for cardiovascular disease and cardiovascular stress hyperactivity in children with smoking parents.
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Patient Exposure to Pregabalin During Pregnancy: Safe or Unsafe?
Authors: Naveed Siddiqui Araj , Ahmed Shah Fakiha , Naveed Siddiqui Yamna
Published: November 2023

Madam,
pregabalin is an anticonvulsant used mainly for the treatment of epilepsy, neuropathic pain, and anxiety. Recently, a safety advisory by the Drug Regulatory Authority of Pakistan (DRAP) associated the use of pregabalin during pregnancy with a slightly increased risk of major congenital malformations in the inborn child.1 Given that a considerable portion of pregnant women in Pakistan self-medicate, there is an immediate need to address this issue.2
This decision was made in consideration of a drug safety update issued by the Medicines and Healthcare products Regulatory Agency (MHRA) of the United Kingdom, in which findings from a European study and a Nordic observational study were thoroughly analysed before coming to the conclusion.3 The MHRA-reviewed Nordic study examined the effect of pregabalin exposure on 2,700 pregnant women and observed a higher prevalence of major congenital abnormalities (5.9%) in babies exposed to pregabalin compared to babies not exposed to any anti-epileptic drug (4.1%).4 Pregabalin-exposed children had a slightly higher risk of developing certain anomalies of the eye, face, the nervous and urological systems.3 In light of these findings, the MHRA decided that pregabalin product labelling should be updated, and pregnant women should be advised to use effective contraception while taking the medication, or altogether avoid it, unless absolutely essential.3 However, MHRA also stated, as the Nordic study was observational and based on registry data, the outcomes could have been influenced by various other factors.3 Furthermore, a few other  researchers have expressed differing opinions regarding the MHRA’s warning. A critical appraisal by Richardson JL et.al. described this update on pregabalin as inadequately supported and leading to confusion and misinformed clinical risk-benefit decision making. This was attributed to certain methodological flaws in the study and low-quality evidence that suggested the possibility of only a minor, unconfirmed risk that could not be solely associated with foetal exposure to pregabalin.5
A multi-centred study should be conducted to develop a better understanding of the role of pregabalin in causing congenital malformations. However, since the MHRA-reviewed Nordic study is the largest population-based study currently available, guidelines given out by the MHRA and DRAP regarding patient exposure to pregabalin during pregnancy cannot be ignored. Public awareness is required to educate pregnant women in Pakistan regarding the risks associated with pregabalin.
Discontinuation of long-established Hydroxyprogesterone Caproate; call for awareness and drug-substitutes: A Letter to the Editor
Authors: Muhammad Affan  , Erum Ilyas
Published: November 2023

Madam,
17-Hydroxyprogesterone caproate is a synthetic progestin medication used to prevent preterm birth in pregnant women with a prior history of preterm birth. The drug has been used worldwide, including in Pakistan (local brand names Gravibinan and Proluton) for the prevention of PTBs and recurrent miscarriages. The drug is potent, cost-effective and readily available as IM injections. The FDA approved drug in 2011 after the Meis trial, which was regarded as a game-changer. [1] But many subsequent trials showed that the drug did not significantly lowered the risks of preterm births.
The PROLONG study, much larger than the Meis trial, that was conducted in association with the FDA between 2009 and 2018 as a confirmatory trial showed practice-changing results that 17 OHPC did not significantly reduce the risk of PTB and neonatal morbidity, hence not confirming treatment efficacy. [2] The FDA ultimately in 2023 issued a statement recalling Makena (17-OHPC) and its generics from the market stating that the drug had no significant role in reducing the risk of PTBs and has potential risks to the offspring in the long term. [3] A study by C. Murphy et. al published in the American Journal of Obstetrics and Gynecology showed an increased risk of prostate, colorectal and pediatric brain cancer in offspring exposed to 17 OHPC especially during the first trimester. [4]
Micronized progesterones (locally available as Progefik and U-Progest) on the contrary, are chemically similar to human progesterone and are therefore regarded as ‘body-identical’. They are administered orally or vaginally and have similar effects as 17-OHPC in the prevention of PTB. A comparative study in India by Shambhavi et.al was one of the various studies to show that no significant difference in the two medications for the prevention of PTB and neonatal morbidity. [5] Micronized progesterone has largely gained popularity in recent years and has replaced 17-OHPC in preventing PTBs especially in women with short cervix.
17-OHPC is still being widely prescribed in Pakistan. Efforts should be made to spread awareness among the healthcare practitioners regarding the disapproval by FDA for continued use of 17-OHPC. Pakistan’s Drug Regulation Authority needs to act accordingly regarding the continued approval of the drug in the country and spread awareness about its substitutes with better potency and reduced risks. Moreover, continued research about the efficacy of other progesterones administered to reduce PTBs and their potential risk factors in the long run is needed.