bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of environmental and genetic factors on the correlation and stability of grain yield components in wheat
Authors: Hristov Nikola , Mladenov Novica , Kondic-Spika Ankica , Marjanovic-Jeromela Ana , Jockovic Bojan , Jacimovic Goran
Published: May 2011

More effective breeding and development of new wheat genotypes depend on an
intricate analysis of the complex relationships among many different traits.
The objective of this paper was to determine the interrelationship, direct
and indirect effects, and stability of different yield components in wheat.
Forty divergent genotypes were analyzed in a three- year study (2005-2007).
Highly significant correlations were found between grain yield per plant and
all the other traits analyzed except spike length, with the only negative
correlation being that with plant height. Path analysis revealed highly
significant direct effects of grain number per spike, grain mass per spike
and 1000 grain weight on grain yield per plant. Analysis of stability
parameters showed that the stability of grain yield per plant depended for
the most part on the stability of grain number per spike, grain mass per
spike and harvest index. Cluster analysis identified genotypes with a high
performance for grain yield per plant and good stability parameters,
indicating the possibility of developing wheat varieties with a high
potential and high stability for a particular trait.
Fruit quality in five apple cultivars trees trained to intensive training system: Geneva y-trellis
Authors: Talaie Alireza , Shojaie-Saadee Mona , Dadashpour Ahmad , Asgari-Sarcheshmeh Ali
Published: May 2011

Orchard intensification is motivated by the desire to produce fruit early in
the life of the orchard to rapidly recover establishment costs.
Intensification is possible by using dwarfing rootstocks that control tree
size, induce early cropping, and produce large quantities of fruit relative
to the amount of wood produced. Therefore, this study attempts to compare
some yield and fruit properties of five apple cultivars grown in the Karaj
area of Iran. The concerned apple cultivars were ?Golab-kohans? (Iranian
cultivar), ?Fuji?, ?Starking?, ?Delbar estival? and ?Prime rose? (commercial
foreign cultivars) that were grafted on M.9 rootstock which were trained in
Geneva Y-trellis system. All of these trees were planted in winter 2004. The
trees were irrigated from the second year after planting and the method of
irrigation was drip irrigation. pH (4.07) and Humidity Content (85.96 %) were
the highest with the ?Golab-kohans? (Iranian cultivar). Also ?Delbar estival?
had the highest fruit length (6.13 cm), L/D (0.87) and TSS (15.77).
?Starking? had the highest fruit weight (145.24 gr), fruit diameter (6.91 cm)
and Ash (0.71 %). In addition, the most dry matter (20.13 %), fruit firmness
(13.13 kg/cm2) and titrable acid (0.72 %) were recorded with ?Fuji?.
Diallel cross analysis for fruit traits in watermelon
Authors: Gvozdanovic-Varga Jelica , Vasic Mirjana , Milic Dragan , Cervenski Janko
Published: May 2011

Current demands of consumers and thus producers are important when targeting
watermelon breeding programs, especially in programs aimed at improvement of
fruit traits. A complete diallel set has been investigated for breeding
values of six watermelon lines, via general and specific combining ability,
relationships between general and specific combining ability, heritability
and heterosis for fruit size, rind thickness, soluble solids and fruit shape.
The lines P2 and P4 were good general combiners for fruit size. These lines
also had high values of specific combining ability in direct and reciprocal
crosses. The lines with negative general combining ability for fruit size (P1
and P5) can be used in breeding for small fruits (4-6 kg), good taste (high
sugar content), desired rind thickness, desired fruit form and high fruit
ratio. Relationships between general and specific combining ability indicated
that the additive effect played an important role in the expression of fruit
weight, rind thickness and sugar content, while fruit shape was inherited
incompletely dominantly.
Identification of Tilletia species using rep-PCR fingerprinting technique
Authors: Zupunski Vesna , Ignjatovic-Micic Dragana , Nikolic Ana , Stankovic Slavica , Jevtic Radivoje , Levic Jelena , Ivanovic Dragica
Published: May 2011

Analyzing 167 non-processed seed samples of wheat, it was found that 145
samples (86.8 %) were contaminated with Tilletia species, while 22 (13.2 %)
samples were not contaminated. By using rep-PCR fingerprinting technique, it
was found that DNA isolates of T. tritici originated from Serbian wheat
samples had 80 % similarity with positive control for T. tritici. One isolate
shared similarity of 60% with T. tritici, T. controversa and T. laevis. It
was supposed that this isolate belongs to T. bromi. Isolate of T. laevis
shared a similarity of 70 % with isolates of T. tritici and T. controversa,
while T. walkeri was more than 10 % similar with T. tritici, T. controversa
and T. laevis. Although T. controversa and T. tritici had high percent of
genetic similarity, they were clustered separately. Our results suggest that
rep-PCR fingerprinting could be a useful tool for monitoring presence of
morphologically similar Tilletia species in wheat production areas.
Identification of novel single nucleotide polymorphism (SNP) in DPB1 gene in ethnic population from West Bengal
Authors: Raha Oindrila , Sarkar B.N. , Veerraju P. , Pramanik Lucy , Rao V.R.
Published: May 2011

HLA-DP antigens present peptides to CD4+ T cells and play an important role
in autoimmune diseases and parasitic infections. We have sequenced HLA-DPB1
exon-2 from the ethnic populations in West Bengal, India and report a novel
single nucleotide polymorphism (SNP) - rs111221466. The rs111221466 SNP
induced silent mutation from CGA (Arg) to TGA (Stop Codon) and showed a
frequency of 83.24%. In conventional sense, the frequency of novel SNP is
very high. We have sequenced HLA-DPB1 exon-2 from a Bengali Population in
West Bengal, India. HLA-DP antigens present peptides to CD4+ T cells and play
an important role in autoimmune diseases and parasitic infections. Here, we
report a novel single nucleotide polymorphism of HLA-DPB1 gene in the
population. rs111221466 showed a frequency of 83.24, which is important to
note, in view of common polymorphisms involved in disease susceptibility.
Future directions in sintering research
Authors: Upadhyaya G.S.
Published: May 2011

From time to time, the gap between sintering science and technology is being
attempted to be bridged, but there are still a number of unresolved issues in
sintering. So far, only thermal energy was considered for accomplishing
sintering of a powder compact. However, other sources of energy may be
treated exclusively or in combination with others to achieve densification.
The main goal is to tailor the material properties during sintering through
microstructural modifications. But in doing so, the very chemical nature of
the material subjected to sintering needs to be considered. It is at this
stage that the role of electronic structure comes into picture. The present
paper reviews this aspect and proposes how the studies on nano-crystalline
materials are able to validate the very basic electronic processes occurring
during sintering.
Analysis and modeling of sintering of Sr-hexaferrite produced by PIM technology
Authors: Zlatkov B.S. , Nikolic M.V. , Zeljkovic V. , Obradovic N. , Pavlovic V.B. , Aleksic O.
Published: May 2011

The powder injection moulding (PIM) technology is lately becoming more and
more significant due to complex design possibilities and good repeatability.
This technology requires optimization of all steps starting with material and
binder, injection, debinding and sintering parameters. Sintering is one of
the key links in this technology. The powder injection moulding process is
specific as during feedstock injection powder particles mixed into the binder
do not come into mechanical contact. Shrinkage during sintering of PIM
samples is high. In this work we have analyzed and modeled the sintering
process of isotropic PIM samples of Sr-hexaferrite. The Master Sintering
Curve (MSC) principle has been applied to analyze sintering of two types of
PIM Sr-hexaferrite samples with completely removed binder and only the
extraction step of the debinding procedure (thermal debinding proceeding
simultaneously with sintering). Influence of the heating rate on resulting
sample microstructures has also been analyzed. Influence of the sintering
time and temperature was analyzed using three different phenomenological
equations.
Iterative regularity and parent-offspring growth mold of stable grain array in bismuth silicate micro-crystals
Authors: Zhang Z.G. , Wang X.F. , Tian Q.Q.
Published: May 2011

Bismuth silicate micro-crystals with grain array structure were prepared by
sintering method under atmosphere pressure. The samples were characterized
for structural and surface morphological properties by X-ray diffraction
(XRD) and Environmental scanning electron microscopy (ESEM). The result
shows that stable grain arrays grow by iterative mode. If a stable grain
array eliminates, a new stable grain array will generate. In a stable parent
array, an offspring array may generate after the corresponding partial
elimination of its parent array. If one part of an offspring array stops
growing, it will be as a new parent array, and then its offspring grain
array will create. The sum of the lengths of an offspring array and the
corresponding eliminated part of its parent array is equal to the length of
the next eliminated part of its parent array. It means the growth rate of an
offspring array is equal to that of the corresponding survived part of its
parent array. There is a highly correlation between grain array length and
average grain line spacing. It means that larger average grain line spacing
corresponds to the stable grain array with lager length. When average grain
line spacing increases 1?m, the corresponding array length will increase
approximately 7.6?m.
One-Year Results of a Community-Based Translation of the Diabetes Prevention Program
Authors: Katula Jeffrey A. , Vitolins Mara Z. , Rosenberger Erica L. , Blackwell Caroline S. , Morgan Timothy M. , Lawlor Michael S. , Goff David C.
Published: May 2011

OBJECTIVE

Although the Diabetes Prevention Program (DPP) and the Finnish Diabetes Prevention Study (FDPS) demonstrated that weight loss from lifestyle change reduces type 2 diabetes incidence in patients with prediabetes, the translation into community settings has been difficult. The objective of this study is to report the first-year results of a community-based translation of the DPP lifestyle weight loss (LWL) intervention on fasting glucose, insulin resistance, and adiposity.

RESEARCH DESIGN AND METHODS

We randomly assigned 301 overweight and obese volunteers (BMI 25–40 kg/m2) with fasting blood glucose values between 95 and 125 mg/dL to a group-based translation of the DPP LWL intervention administered through a diabetes education program (DEP) and delivered by community health workers (CHWs) or to an enhanced usual-care condition. CHWs were volunteers with well-controlled type 2 diabetes. A total of 42.5% of participants were male, mean age was 57.9 years, 26% were of a race/ethnicity other than white, and 80% reported having an education beyond high school. The primary outcome is mean fasting glucose over 12 months of follow-up, adjusting for baseline glucose.

RESULTS

Compared with usual-care participants, LWL intervention participants experienced significantly greater decreases in blood glucose (−4.3 vs. −0.4 mg/dL; P < 0.001), insulin (−6.5 vs. −2.7 μU/mL; P < 0.001), homeostasis model assessment of insulin resistance (−1.9 vs. −0.8; P < 0.001), weight (−7.1 vs. −1.4 kg; P < 0.001), BMI (−2.1 vs. −0.3 kg/m2; P < 0.001), and waist circumference (−5.9 vs. −0.8 cm; P < 0.001).

CONCLUSIONS

This translation of the DPP intervention conducted in community settings, administered through a DEP, and delivered by CHWs holds great promise for the prevention of diabetes by significantly decreasing glucose, insulin, and adiposity.
Trimester dependent preterm births in pregnancy with genital herpes
Authors: Bánhidy Ferenc , Dudás István , Czeizel Andrew
Published: May 2011

Previous studies reported controversial results regarding the possible association of recurrent genital herpes during pregnancy with a higher risk of preterm birth/low birth weight in newborns. Thus, birth outcomes of mothers with prospective and medically recorded symptomatic recurrent genital herpes confirmed by serological examination and of mothers without genital herpes were compared in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities. Our results showed that of 38,151 newborn infants, 86 (0.23%) had mothers with symptomatic recurrent genital herpes confirmed by serological examination during pregnancy. The rate of preterm births (14.0% vs. 9.2%) was higher in babies born to mothers with symptomatic recurrent genital herpes (OR with 95% CI: 1.7, 1.0–3.1) and this increase showed a trimester dependence with the highest rate in the third trimester (23.5%; OR with 95% CI: 2.6, 1.5–4.5). In conclusion, clinically diagnosed recurrent genital herpes during the third trimester of pregnancy associated with high risk for preterm birth.
Cadmium exposure induced itai-itai-like syndrome in male rats
Authors: Chen Xiao , Zhu Guoying , Jin Taiyi , Gu Shuzhu , Tan Mingguang , Xiao Hanfang , Qiu Jing
Published: May 2011

Fourteen Sprague-Dawley male rats were randomly divided into 2 groups which were given CdCl2 at the doses of 0 and 1.5 mg /kg for 12 weeks. Before sacrifice, microCT scanning were performed on the proximal tibia and urine were collected for cadmium and N-acetyl-beta-D-glucosaminidase assay, then all of rats were sacrificed and blood was collected for biomarkers measurement; bone tissues were collected for bone mass, histology and biomechanical analysis. The cadmium in blood, urine, bone and kidney of rats treated with cadmium was significantly higher than those in the control group. The bone mineral density, and bone mineral ability of rats treated with cadmium were obviously decreased by 20%–50% compared to controls. Bone microstructure index and trabecular separation of rats treated with cadmium were obviously lower (−50%) and significantly higher (+150%) than that in the control group. Bone biomechanical property decreased by 30%–60% in cadmium treated rats compared to control. Tartrate-resistant acid phosphatase 5b and alkaline phosphatase levels of rats treated with cadmium were significantly higher than those in control, but serum osteocalcin level decreased greatly by cadmium. Obvious proximal tubule damage occurred after cadmium exposure. These observations gave clear and comprehensive evidence that cadmium exposure could induce itai-itai-like syndrome in male rats.
Modelling of high-contrast grating mirrors. The impact of imperfections on their performance in VCSELs
Authors: Dems M.
Published: May 2011

The article presents numerical investigations of high-contrast grating mirrors. First, it shows the basis of a new numerical method for computing the parameters of the grating and next it describes the results of the analysis of the manufacturing imperfections impact on the reflection coefficient. Finally, it shows the considerations on the performance of high-contrast gratings in typical designs of VCSELs.
Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies
Authors: Jurewicz Joanna , Hanke Wojciech
Published: May 2011

Phthalates are a family of industrial chemicals that have been used for a variety of purposes. As the potential consequences of human exposure to phthalates have raised concerns in the general population, they have been studied in susceptible subjects such as pregnant women, infants and children. This article aims at evaluating the impact of exposure to phthalates on reproductive outcomes and children health by reviewing most recent published literature. Epidemiological studies focusing on exposure to phthalates and pregnancy outcome, genital development, semen quality, precocious puberty, thyroid function, respiratory symptoms and neurodevelopment in children for the last ten years were identified by a search of the PubMed, Medline, Ebsco, Agricola and Toxnet literature bases. The results from the presented studies suggest that there are strong and rather consistent indications that phthalates increase the risk of allergy and asthma and have an adverse impact on children’s neurodevelopment reflected by quality of alertness among girls, decreased (less masculine) composite score in boys and attention deficit hyperactivity disorder. Results of few studies demonstrate negative associations between phthalate levels commonly experienced by the public and impaired sperm quality (concentration, morphology, motility). Phthalates negatively impact also on gestational age and head circumference; however, the results of the studies were not consistent. In all the reviewed studies, exposure to phthalates adversely affected the level of reproductive hormones (luteinizing hormone, free testosterone, sex hormone-binding globulin), anogenital distance and thyroid function. The urinary le vels of phthalates were significantly higher in the pubertal gynecomastia group, in serum in girls with premature thelarche and in girls with precocious puberty. Epidemiological studies, in spite of their limitations, suggest that phthalates may affect reproductive outcome and children health. Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented.
Unsteady flow in a viscous oil transporting centrifugal pump
Authors: Li Wen-Guang
Published: May 2011

Acoustic resonances are frequently fatal problems in centrifugal pump operations. Low pressure pulsation of fluid in the blade pass frequency is helpful to prevent from such problems. In addition, for a high quality centrifugal pump, a lower broadband noise level is also on demand. The acoustic resonance and broadband noise are associated with unsteadiness of flow in the pump. Even there exist extensive analyses of unsteady flow in centrifugal pumps by means of CFD so far, the effect of high viscosity of fluid pumped on the unsteadiness of flow feature remains unclear. Thus, the unsteady flow in an experimental centrifugal pump was exploited numerically when it transported the liquids with different viscosities. The velocity profiles at the impeller discharge were validated with the results of LDV measurement for water. The viscosity effect on the fluctuation of flow in the volute was clarified quantitatively. It was shown the increasing viscosity of fluid makes the fluctuation in flow variables less substantial and results into a less noticed tendency of separation of flow from the blade pressure side.
Intraoperative Blood Loss & operating time in Tonsillectomy: Is Electrodissection Better?
Authors: Guragain R , Bhusal CL , Adhikari P , Pokharel R
Published: May 2011

DOI: 10.3126/njenthns.v1i1.4728 Nepalese J ENT Head Neck Surg Vol.1 No.1 (2010) p.6-7
Is Antral Wash Out Really Indicated in Acute Bacterial Rhino Sinusitis?
Authors: KC Toran
Published: May 2011

Key words: sinusitis; antral wash out; conservative treatmentDOI: 10.3126/njenthns.v1i1.4730 Nepalese J ENT Head Neck Surg Vol.1 No.1 (2010) p.12-13
Tuberculous Otitis Media with Facial Palsy: A Case Report
Authors: Adhikari P , Guragain R , Bhusal CL
Published: May 2011

DOI: 10.3126/njenthns.v1i1.4732 Nepalese J ENT Head Neck Surg Vol.1 No.1 (2010) p.17-18
Fibroma of Epiglottis
Authors: Karki P , Gurung U , Baskota DK
Published: May 2011

Key words: fibroma; epiglottis; larynx; excisionDOI: 10.3126/njenthns.v1i1.4733 Nepalese J ENT Head Neck Surg Vol.1 No.1 (2010) p.19-20
Undergraduate Training in ENT Head and Neck Surgery in Nepal: Is there any uniformity?
Authors: Guragain R , Bhatta R
Published: May 2011

DOI: 10.3126/njenthns.v1i1.4736 Nepalese J ENT Head Neck Surg Vol.1 No.1 (2010) p.27-29
Diagnosis and Treatment of Sinonasal Inverted Papilloma
Authors: Thapa N
Published: May 2011

DOI: 10.3126/njenthns.v1i1.4737 Nepalese J ENT Head Neck Surg Vol.1 No.1 (2010) p.30-33
Modified Sistrunk's Operation
Authors: Baskota DK
Published: May 2011

Key words: thyroglossal cyst/fistula; Sistrunk's operation; modified Sistrunk operation; body of hyoidDOI: 10.3126/njenthns.v1i1.4738 Nepalese J ENT Head Neck Surg Vol.1 No.1 (2010) p.34-35
New Editorial Board and Peer Reviewers of Nepalese J ENT Head Neck Surgery
Authors: Adhikari P
Published: May 2011

DOI: 10.3126/njenthns.v1i2.4751 Nepalese J ENT Head Neck Surg Vol.1 No.2 (2010) p.2
Comparison of Pre and Postoperative Hearing Results after Cartilage Augmentation Type III Tympanoplasty
Authors: Shrestha BL , Bhattarai H , Bhusai CL
Published: May 2011

Keywords: Air bone gap; chronic media (squamous); canal wall down mastoidectomy; cartilage augmentation type III tympanoplastyDOI: 10.3126/njenthns.v1i2.4752 Nepalese J ENT Head Neck Surg Vol.1 No.2 (2010) p.3-5
Pattern of Sinonasal Tumors in Eastern Nepal
Authors: Nepal A , Joshi RR , Chettri ST , Karki S
Published: May 2011

Keywords: Carcinoma; maxillectomy, papilloma; sinonasal tumorDOI: 10.3126/njenthns.v1i2.4755 Nepalese J ENT Head Neck Surg Vol.1 No.2 (2010) p.9-11
Microbiological Evaluation of an Active Tubotympanic Type of Chronic Suppurative Otitis Media
Authors: Srivastava A , Singh RK , Varshney S , Gupta P , Bist SS , Bhagat S , Gupta N
Published: May 2011

Keywords: Antibiotics; chronic otitis media; microbiologyDOI: 10.3126/njenthns.v1i2.4758 Nepalese J ENT Head Neck Surg Vol.1 No.2 (2010) p.14-16
Early Complications of Total Laryngectomy: A Retrospective Study
Authors: Maharjan R , Adhikari P , Khalilullah S , Sinha BK , Baskota DK
Published: May 2011

Keywords: Laryngeal cancer; total laryngectomy; early complicationsDOI: 10.3126/njenthns.v1i2.4759 Nepalese J ENT Head Neck Surg Vol.1 No.2 (2010) p.17-18
Gastric Heterotopia Nasopharynx
Authors: Gurung U , Shrivastav A , Guragain RPS , Bhusal CL
Published: May 2011

Keywords: Heterotopia; nasopharynx, excisionDOI: 10.3126/njenthns.v1i2.4761 Nepalese J ENT Head Neck Surg Vol.1 No.2 (2010) p.21-22
Comparison of Dose Response Models for Predicting Normal Tissue Complications from Cancer Radiotherapy: Application in Rat Spinal Cord
Authors: Adamus-Górka Magdalena , Mavroidis Panayiotis , Lind Bengt K. , Brahme Anders
Published: May 2011

Seven different radiobiological dose-response models have been compared with regard to their ability to describe experimental data. The first four models, namely the critical volume, the relative seriality, the inverse tumor and the critical element models are mainly based on cell survival biology. The other three models: the Lyman (Gaussian distribution), the parallel architecture and the Weibull distribution models are semi-empirical and rather based on statistical distributions. The maximum likelihood estimation was used to fit the models to experimental data and the χ2-distribution, AIC criterion and F-test were applied to compare the goodness-of-fit of the models. The comparison was performed using experimental data for rat spinal cord injury. Both the shape of the dose-response curve and the ability of handling the volume dependence were separately compared for each model. All the models were found to be acceptable in describing the present experimental dataset (p > 0.05). For the white matter necrosis dataset, the Weibull and Lyman models were clearly superior to the other models, whereas for the vascular damage case, the Relative Seriality model seems to have the best performance although the Critical volume, Inverse tumor, Critical element and Parallel architecture models gave similar results. Although the differences between many of the investigated models are rather small, they still may be of importance in indicating the advantages and limitations of each particular model. It appears that most of the models have favorable properties for describing dose-response data, which indicates that they may be suitable to be used in biologically optimized intensity modulated radiation therapy planning, provided a proper estimation of their radiobiological parameters had been performed for every tissue and clinical endpoint.
Novel Natural Inhibitors of CYP1A2 Identified by in Silico and in Vitro Screening
Authors: Zhu Ruixin , Hu Liwei , Li Haiyun , Su Juan , Cao Zhiwei , Zhang Weidong
Published: May 2011

Inhibition of cytochrome P450 (CYP) is a major cause of herb–drug interactions. The CYP1A2 enzyme plays a major role in the metabolism of drugs in humans. Its broad substrate specificity, as well as its inhibition by a vast array of structurally diverse herbal active ingredients, has indicated the possibility of metabolic herb–drug interactions. Therefore nowadays searching inhibitors for CYP1A2 from herbal medicines are drawing much more attention by biological, chemical and pharmological scientists. In our work, a pharmacophore model as well as the docking technology is proposed to screen inhibitors from herbal ingredients data. Firstly different pharmaphore models were constructed and then validated and modified by 202 herbal ingredients. Secondly the best pharmaphore model was chosen to virtually screen the herbal data (a curated database of 989 herbal compounds). Then the hits (147 herbal compounds) were continued to be filtered by a docking process, and were tested in vitro successively. Finally, five of eighteen candidate compounds (272, 284, 300, 616 and 817) were found to have inhibition of CYP1A2 activity. The model developed in our study is efficient for in silico screening of large herbal databases in the identification of CYP1A2 inhibitors. It will play an important role to prevent the risk of herb–drug interactions at an early stage of the drug development process.
Copper(I)-Catalyzed [ 3+ 2] Cycloaddition of 3-Azidoquinoline-2,4(1H,3H)-diones with Terminal Alkynes
Authors: Kafka Stanislav , Hauke Sylvia , Salcinovic Arjana , Soidinsalo Otto , Urankar Damijana , Kosmrlj Janez
Published: May 2011

3-Azidoquinoline-2,4(1H,3H)-diones 1, which are readily available from 4-hydroxyquinolin-2(1H)-ones 4 via 3-chloroquinoline-2,4(1H,3H)-diones 5, afford, in copper(I)-catalyzed [3 + 2] cycloaddition reaction with terminal acetylenes, 1,4-disubstituted 1,2,3-triazoles 3 in moderate to excellent yields. The structures of compounds 3 were confirmed by 1H and 13C-NMR spectroscopy, combustion analyses and mass spectrometry.
Synthesis of the Key Intermediate of Coenzyme Q10
Authors: Mu Fan-Song , Luo Meng , Fu Yu-Jie , Zhang Xuan , Yu Ping , Zu Yuan-Gang
Published: May 2011

(2’E)-1-(3-methyl-4-p-toluenesulfonyl-2-butene)-6-methyl-2,3,4,5-tetramethoxybenzene (4) is the key intermediate in the synthesis of coenzyme Q10 via a coupling reaction with solanesyl bromide. In this paper, we report a simple and effective synthesis of compound 4, starting with the readily available and inexpensive precursors p-toluenesulfonyl chloride (TsCl) and isoprene to obtain (2E)-1-p-toluenesulfonyl-2-methyl-4-hydroxy-2-butene (3) by addition, esterification and hydrolysis. Application of the Friedel-Crafts alkylation to compound 3, followed by the addition of 2,3,4,5-tetramethoxytoluene (TeMT), assembled the two parts into compound 4. The key parameters of each reaction were optimized at the same time, and the four total operations needed to produced compound 4 had a 27.9% overall yield under the optimized conditions. The structures of the compounds were characterized by 1H-NMR, IR and MS. This alternative process has the potential to be used for large-scale process.
Microfabrication and Applications of Opto-Microfluidic Sensors
Authors: Zhang Daiying , Men Liqiu , Chen Qiying
Published: May 2011

A review of research activities on opto-microfluidic sensors carried out by the research groups in Canada is presented. After a brief introduction of this exciting research field, detailed discussion is focused on different techniques for the fabrication of opto-microfluidic sensors, and various applications of these devices for bioanalysis, chemical detection, and optical measurement. Our current research on femtosecond laser microfabrication of optofluidic devices is introduced and some experimental results are elaborated. The research on opto-microfluidics provides highly sensitive opto-microfluidic sensors for practical applications with significant advantages of portability, efficiency, sensitivity, versatility, and low cost.
Models of Care for Early-Stage Breast Cancer in Canada
Authors: Madarnas Y. , Joy A.A. , Verma S. , Sehdev S. , Lam W. , Sideris L.
Published: May 2011

There is growing evidence that follow-up for patients with early breast cancer (EBC) can be effectively carried out by the primary health care provider if a plan is in place. Here, we present data from a recent survey conducted in Ontario indicating that a shared-care model could work if communication between all health professionals involved in the care of ebc patients were to be improved. Patients and primary care providers benefit when the specialist provides written information about what their roles are and what to expect. Primary care providers need to have easy access to the specialist to discuss areas of concern. Patients also need to share responsibility for their care, ensuring that they attend follow-up visits on a regular basis and that they discuss areas of concern with their primary health care provider. A shared-care model has the potential to provide the best care for the least cost to the health system.
The role of the cantilever in Kelvin probe force microscopy measurements
Authors: Elias George , Glatzel Thilo , Meyer Ernst , Schwarzman Alex , Boag Amir , Rosenwaks Yossi
Published: May 2011

The role of the cantilever in quantitative Kelvin probe force microscopy (KPFM) is rigorously analyzed. We use the boundary element method to calculate the point spread function of the measuring probe: Tip and cantilever. The calculations show that the cantilever has a very strong effect on the absolute value of the measured contact potential difference even under ultra-high vacuum conditions, and we demonstrate a good agreement between our model and KPFM measurements in ultra-high vacuum of NaCl monolayers grown on Cu(111). The effect of the oscillating cantilever shape on the KPFM resolution and sensitivity has been calculated and found to be relatively small.
Sequential Au(I)-catalyzed reaction of water with o-acetylenyl-substituted phenyldiazoacetates
Authors: Zhou Lei , Liu Yizhou , Zhang Yan , Wang Jianbo
Published: May 2011

The gold(I)-catalyzed reaction of water with o-acetylenyl-substituted phenyldiazoacetates provides 1H-isochromene derivatives in good yields. The reaction follows a catalytic sequence of gold carbene formation/water O–H insertion/alcohol-alkyne cyclization. The gold(I) complex is the only catalyst in each of these steps.
La quantité indéterminée de la matière dans la génération. Jean de Jandun et Walter Burley (1280-1340)
Authors: Lamy Alice
Published: May 2011

Résumé Jean de Jandun et Walter Burley, commentateurs des œuvres de Aristote et d’Averroès à l’Université de Paris aux xiii e et xiv e  siècles, juxtaposent à la lettre les enseignements de leurs sources au risque d’aboutir à des théories problématiques. Pour décrire le mouvement substantiel de la génération, ils retiennent d’Aristote les principes métaphysiques de la matière, la forme et la privation, et leur ajoutent la problématique introduite par les philosophes arabes de la possible corporéité et de la quantification de la matière par des dimensions indéterminées qui en sont inséparables. Cette quantification devient nécessaire pour faire de la matière un sujet adéquat au changement substantiel. Pourtant, la nature quantitative de la matière demeure indéfinissable et met en péril la théorie médiévale de la génération.
La vocation et le métier de sociologue de la philosophie
Authors: Deprez Stanislas
Published: May 2011

Résumé Depuis 2007, Louis Pinto a publié cinq livres, développant une sociologie de la philosophie entamée il y a plus de vingt ans. L’objet et la méthode de ces travaux, explicitement situés dans le prolongement de l’œuvre de Bourdieu, sont précisés et rapprochés de deux autres ouvrages récents (Jean-Louis Fabiani et Stéphan Soulié). Il s’agit de préciser la portée et le cadre de ces recherches et leur intérêt pour les philosophes, qui en sont à la fois l’objet et les destinataires.
La ley municipal de Basilipo
Authors: D'Ors Álvaro
Published: May 2011

No disponible.
La conception de l’Étre chez Mélissus
Authors: Wiśniewski Bohdan
Published: May 2011

No disponible.
Griego πρέσβυς y variantes dialectales
Authors: García Ramón J. L.
Published: May 2011

No disponible.
Reparto modal en las interrogativas en el estilo indirecto latino
Authors: Morano Ciriaca
Published: May 2011

No disponible.
Eudemo y el «catálogo de geómetras» de Proclo
Authors: Eggers Lan Conrado
Published: May 2011

No disponible.
El progreso de la epigrafía romana de Hispania (1977-1982)
Authors: Castillo Carmen
Published: May 2011

No disponible.
La elección de arcontes en Arist., Athenaion Politeia 22.5
Authors: González de la Red Orencia
Published: May 2011

No disponible.
En torno a deuas corniscas sacrum (CIL 12 975 = VI 96, 30691)
Authors: Jiménez Zamudio Rafael
Published: May 2011

No disponible.
Las fuentes de Hesiodo y la composicion de sus poemas
Authors: Adrados Francisco R.
Published: May 2011

No disponible.
El dativo latino epigráfico en -ā
Authors: Villar F.
Published: May 2011

No disponible.
La uia Heraclea en el Occidente: mito, arqueología, propaganda, historia
Authors: Knapp Robert C.
Published: May 2011

No disponible.
On the question of priority of Homer and Hesiod
Authors: Tsagarakis Odysseus
Published: May 2011

No disponible.
Homer Alpha 1
Authors: Böhme Robert
Published: May 2011

No disponible.
La puntuación bucólica y el género literario: Calpurnio y las Eglogas de Virgilio
Authors: Baños José Miguel
Published: May 2011

No disponible.
Una nueva lectura de IG V 1, 234
Authors: Aguirre Castro Mercedes
Published: May 2011

No disponible.
Aportaciones críticas a una edición de la Mulomedicina de Vegecio
Authors: Robles Gómez José María
Published: May 2011

No disponible.
Apuleyo, Tácito y Salustio
Authors: Fernández López María Concepción
Published: May 2011

No disponible.
¿Un modelo literario de la descripción de la peste de Atenas?
Authors: Alsina José
Published: May 2011

No disponible.
Time in Seneca: past, present, future
Authors: Motto Anna Lydia , Clark John R.
Published: May 2011

No disponible.
On the Indo-European ablative
Authors: Shields K.
Published: May 2011

No disponible.
Aportación al conocimiento del texto de la Historia de los animales de Eliano y asuntos conexos
Authors: Vara J.
Published: May 2011

No disponible.
Notas lexicográficas surgidas de la redacción de nombres propios del
Authors: González Castro J. F.
Published: May 2011

No disponible.
Anotaciones al texto del libro II de Tito Livio
Authors: Fontán Antonio
Published: May 2011

No disponible.
Anacreonte 2 PMG y la canción sefardí «La mar está en fortuna»
Authors: Gangutia Elícegui Elvira
Published: May 2011

No disponible.
Problemas linguísticos en los escritos hipocráticos: el tratado «Sobre los humores»
Authors: López Férez Juan Antonio
Published: May 2011

No disponible.
Un problema de lengua homérica: la desinencia -φι
Authors: Nieto Hernández Purificación
Published: May 2011

No disponible.
Sobre los supuestos lesbismos del dialecto cirenaico
Authors: Striano Corrochano Araceli
Published: May 2011

No disponible.
La evolucion del diptongo οι en beocio
Authors: Méndez Dosuna Julián
Published: May 2011

No disponible.
Veia: apud oscos dicebatur plaustrum (P. F., 506,3)
Authors: Nieto Emilio
Published: May 2011

No disponible.
La expresión de la función Manera en griego
Authors: Crespo Emilio
Published: May 2011

No disponible.
Himno a Deméter 43-46. Adaptación de un motivo anatolio
Authors: Bernabé Alberto
Published: May 2011

No disponible.
Some new Plotinian emendations
Authors: Kalligas Paul
Published: May 2011

No disponible.
Armonizaciones en Mt. 11,8; 10; 16
Authors: O’Callaghan José
Published: May 2011

No disponible.
La posición dialectal del euboico
Authors: Del Barrio M.ª Luisa
Published: May 2011

No disponible.
El tratamiento de los nombres propios en los textos de Vetus Latina (I y II Samuel)
Authors: Moreno Hernández Antonio
Published: May 2011

No disponible.
Sobre el campo semántico de la política en Eurípides
Authors: Vílchez Mercedes
Published: May 2011

No disponible.
Rodio εσπραΤεν
Authors: Striano Corrochano Araceli
Published: May 2011

No disponible
The reversal of Agamemnon and Menelaus in Euripides’ Iphigenia at Aulis
Authors: Ryzman Marlene
Published: May 2011

No disponible
A study of the psychic term νόος in the Greek lyric poets (excluding Pindar and Βacchylides)
Authors: Darcus Sullivan Shirley
Published: May 2011

No disponible
Los antípodas de la Bucólica VI
Authors: Florio Rubén
Published: May 2011

No disponible
Denique, demum, tandem y postremo: estudio funcioestructural (con especial referencia a la obra lucreciana)
Authors: Gutiérrez Galindo Marco A.
Published: May 2011

No disponible
ἀρνόν en PGurob 22 y el empleo del término ἀρνίον en los papiros documentales
Authors: Berenguer Sánchez José A.
Published: May 2011

No disponible
Ejemplos del griego rabinico a la luz del tesoro lexicográfico del DGE
Authors: Sznol Shifra
Published: May 2011

No disponible
The visit of Athena to Achilles in Iliad I
Authors: Hooker J. T.
Published: May 2011

No disponible
Alexander, Hannibal, and Scipio in Lucian
Authors: Baldwin Barry
Published: May 2011

No disponible
La terminología técnica en la traducción latina del siglo XII del Περὶ ἀέρων... hipocrático
Authors: Ochoa José A.
Published: May 2011

No disponible
Una nota a Petron., Sat. XLV 3
Authors: Bajoni Maria Grazia
Published: May 2011

No disponible
Nuevos textos de Vetus latina (1 Reyes 22). Edición y estudio
Authors: Moreno Hernández Antonio
Published: May 2011

No disponible
Datation d’Olympiodore l’Alchimiste
Authors: Letrouit Jean
Published: May 2011

No disponible
Los excerpta de Beda (De Temporum Ratione 25-35) en el ms. ACA, Ripoll 225
Authors: Gómez Pallarés Juan
Published: May 2011

No disponible
En torno a la composición en la prosa médica griega antigua
Authors: Santana Henríquez Germán
Published: May 2011

No disponible
La metapoética virgiliana
Authors: Pendás de Buzón Ana María , Schniebs de Rossi Alicia
Published: May 2011

No disponible
La interpretación antigua de los versos líricos de Horacio
Authors: Del Castillo Marina
Published: May 2011

No disponible
Aportaciones de la crítica literaria neoplatónica a la comprensión de Platón como escritor
Authors: Ruiz Yamuza Emilia
Published: May 2011

No disponible
Mapping Learning Outcomes and Assignment Tasks for SPIDER Activities
Authors: Brodie Lyn
Published: May 2011

Modern engineering programs have to address rapidly changing technical content and have to enable students to develop transferable skills such as critical evaluation, communication skills and lifelong learning. This paper introduces a combined learning and assessment activity that provides students with opportunities to develop and practice their soft skills, but also extends their theoretical knowledge base. Key tasks included self directed inquiry, oral and written communication as well as peer assessment. To facilitate the SPIDER activities (Select, Prepare and Investigate, Discuss, Evaluate, Reflect), a software tool has been implemented in the learning management system Moodle. Evidence shows increased student engagement and better learning outcomes for both transferable as well as technical skills. The study focuses on generalising the relationship between learning outcomes and assignment tasks as well as activities that drive these tasks. Trail results inform the approach. Staff evaluations and their views of assignments and intended learning outcomes also supported this analysis.
A Conceptual Model of eLearning Adoption
Authors: Abbad Muneer
Published: May 2011

Internet-based learning systems are being used in many universities and firms but their adoption requires a solid understanding of the user acceptance processes. The technology acceptance model (TAM) has been used to test the acceptance of various technologies and software within an e-learning context. This research aims to discuss the main factors of a successful e-learning adoption by students. A conceptual research framework of e-learning adoption is proposed based on the TAM model.
Towards More Authentic Learning in Hypermedia
Authors: Tervakari Anne-Maritta , Silius Kirsi
Published: May 2011

A major challenge in teaching hypermedia is to illustrate how varying dimensions of using context are related to user's quality experience of online services. The Urban Computing Lab (UCL) tool was developed for students to collect rich information for further analysis about quality experiences of online services in authentic situations. Meaningful learning from the real world problems in authentic contexts enhances learning of abstract and theoretical issues.
Improved Cooperation between Schools and Science Labs by Adapting Experiments to the Curriculum
Authors: Sallier René , Beckhäuser Katja , Brück Benjamin , Schütze Andreas
Published: May 2011

Science labs have repeatedly shown their impact on high school students for increasing the interest in natural sciences and engineering. Due to the fact that pupils are experimenting independently, their natural interest in research can be re-activated due to improved intrinsic motivation. However, with the increasing density in school curricula - in Germany especially caused by the reduction of the high school duration by one year - many teachers do not find the time to visit science labs due to their often extracurricular topics. For our lab SinnTec, which is focused on sensors as the â??technical senses
Transcription Factor Nkx2-3 Controls the Vascular Identity and Lymphocyte Homing in the Spleen
Authors: Czömpöly Tamás , Lábadi Árpád , Kellermayer Zoltán , Olasz Katalin , Arnold Hans-Henning , Balogh Péter
Published: May 2011

The vasculature in the spleen and peripheral lymph nodes (pLNs) is considerably different, which affects both homing of lymphocytes and antigenic access to these peripheral lymphoid organs. In this paper, we demonstrate that in mice lacking the homeodomain transcription factor Nkx2-3, the spleen develops a pLN-like mRNA expression signature, coupled with the appearance of high endothelial venules (HEVs) that mediate L-selectin–dependent homing of lymphocytes into the mutant spleen. These ectopic HEV-like vessels undergo postnatal maturation and progressively replace MAdCAM-1 by pLN addressin together with the display of CCL21 arrest chemokine in a process that is reminiscent of HEV formation in pLNs. Similarly to pLNs, development of HEV-like vessels in the Nkx2-3–deficient spleen depends on lymphotoxin-β receptor-mediated signaling. The replacement of splenic vessels with a pLN-patterned vasculature impairs the recirculation of adoptively transferred lymphocytes and reduces the uptake of blood-borne pathogens. The Nkx2-3 mutation in BALB/c background causes a particularly disturbed splenic architecture, characterized by the near complete lack of the red pulp, without affecting lymph nodes. Thus, our observations reveal that the organ-specific patterning of splenic vasculature is critically regulated by Nkx2-3, thereby profoundly affecting the lymphocyte homing mechanism and blood filtering capacity of the spleen in a tissue-specific manner.
Ligation of Notch Receptors in Human Conventional and Plasmacytoid Dendritic Cells Differentially Regulates Cytokine and Chemokine Secretion and Modulates Th Cell Polarization
Authors: Pérez-Cabezas Begoña , Naranjo-Gómez Mar , Bastos-Amador Patricia , Requena-Fernández Gerard , Pujol-Borrell Ricardo , Borràs Francesc E.
Published: May 2011

Notch signaling is involved in multiple cellular processes. Recent data also support the prominent role of Notch signaling in the regulation of the immune response. In this study, we analyzed the expression and function of Notch receptors and ligands on both human blood conventional dendritic cells (cDCs) and plasmacytoid DCs (pDCs). The expression and modulation upon TLR activation of Notch molecules partially differed between cDCs and pDCs, but functional involvement of the Notch pathway in both cell types was clearly revealed by specific inhibition using DAPT. Beyond the induction of Notch target genes and modulation of maturation markers, Notch pathway was also involved in a differential secretion of some specific cytokines/chemokines by DC subsets. Whereas Notch ligation induced IL-10 and CCL19 secretion in cDCs, Notch inhibition resulted in a diminished production of these proteins. With regard to pDCs, Notch activation induced TNF-α whereas Notch inhibition significantly abrogated the secretion of CCL19, CXCL9, CXCL10, and TNF-α. Additionally, Notch modulation of DC subsets differentially affected Th polarization of allostimulated T cells. Our results suggest that the Notch pathway may function as an additional mechanism controlling human DC responses, with differential activity on cDCs and pDCs. This control mechanism may ultimately contribute to define the local milieu promoted by these cells under the particular conditions of the immune response.
Improving Prognosis Estimation in Patients with Heart Failure and the Cardiorenal Syndrome
Authors: Abdel-Qadir Husam M. , Chugh Shaan , Lee Douglas S.
Published: May 2011

The coexistence of heart failure and renal dysfunction constitutes the “cardiorenal syndrome” which is increasingly recognized as a marker of poor prognosis. Patients with cardiorenal dysfunction constitute a large and heterogeneous group where individuals can have markedly different outcomes and disease courses. Thus, the determination of prognosis in this high risk group of patients may pose challenges for clinicians and for researchers alike. In this paper, we discuss the cardiorenal syndrome as it pertains to the patient with heart failure and considerations for further refining prognosis and outcomes in patients with heart failure and renal dysfunction. Conventional assessments of left ventricular function, renal clearance, and functional status can be complemented with identification of coexistent comorbidities, medication needs, microalbuminuria, anemia, biomarker levels, and pulmonary pressures to derive additional prognostic data that can aid management and provide future research directions for this challenging patient group.
The Ambulatory and Home Care Record: A Methodological Framework for Economic Analyses in End-of-Life Care
Authors: Guerriere Denise N. , Coyte Peter C.
Published: May 2011

Provision of end-of-life care in North America takes place across a multitude of settings, including hospitals, ambulatory clinics and home settings. As a result, family caregiving is characteristically a major component of care within the home. Accordingly, economic evaluation of the end-of-life care environment must devote equal consideration to resources provided by the public health system as well as privately financed resources, such as time and money provided by family caregivers. This paper addresses the methods used to measure end-of-life care costs. The existing empirical literature will be reviewed in order to assess care costs with areas neglected in this body of literature to be identified. The Ambulatory and Home Care Record, a framework and tool for comprehensively measuring costs related to the provision and receipt of end-of-life care across all health care settings, will be described and proposed. Finally, areas for future work will be identified, along with their potential contribution to this body of knowledge.