bluuebunny/crossref_metadata_2025 huggingface dataset:
Selective Targeting of Human and Animal Pathogens of the Helicobacter Genus by Flavodoxin Inhibitors: Efficacy, Synergy, Resistance and Mechanistic Studies
Authors: Salillas Sandra , Galano-Frutos Juan José , Mahía Alejandro , Maity Ritwik , Conde-Giménez María , Anoz-Carbonell Ernesto , Berlamont Helena , Velazquez-Campoy Adrian , Touati Eliette , Mamat Uwe , Schaible Ulrich E. , Gálvez José A. , Díaz-de-Villegas María D. , Haesebrouck Freddy , Aínsa José A. , Sancho Javier
Published: September 2021

Antimicrobial resistant (AMR) bacteria constitute a global health concern. Helicobacter pylori is a Gram-negative bacterium that infects about half of the human population and is a major cause of peptic ulcer disease and gastric cancer. Increasing resistance to triple and quadruple H. pylori eradication therapies poses great challenges and urges the development of novel, ideally narrow spectrum, antimicrobials targeting H. pylori. Here, we describe the antimicrobial spectrum of a family of nitrobenzoxadiazol-based antimicrobials initially discovered as inhibitors of flavodoxin: an essential H. pylori protein. Two groups of inhibitors are described. One group is formed by narrow-spectrum compounds, highly specific for H. pylori, but ineffective against enterohepatic Helicobacter species and other Gram-negative or Gram-positive bacteria. The second group includes extended-spectrum antimicrobials additionally targeting Gram-positive bacteria, the Gram-negative Campylobacter jejuni, and most Helicobacter species, but not affecting other Gram-negative pathogens. To identify the binding site of the inhibitors in the flavodoxin structure, several H. pylori-flavodoxin variants have been engineered and tested using isothermal titration calorimetry. An initial study of the inhibitors capacity to generate resistances and of their synergism with antimicrobials commonly used in H. pylori eradication therapies is described. The narrow-spectrum inhibitors, which are expected to affect the microbiota less dramatically than current antimicrobial drugs, offer an opportunity to develop new and specific H. pylori eradication combinations to deal with AMR in H. pylori. On the other hand, the extended-spectrum inhibitors constitute a new family of promising antimicrobials, with a potential use against AMR Gram-positive bacterial pathogens.
Applications of Adductomics in Chemically Induced Adverse Outcomes and Major Emphasis on DNA Adductomics: A Pathbreaking Tool in Biomedical Research
Authors: Behl Tapan , Rachamalla Mahesh , Najda Agnieszka , Sehgal Aayush , Singh Sukhbir , Sharma Neelam , Bhatia Saurabh , Al-Harrasi Ahmed , Chigurupati Sridevi , Vargas-De-La-Cruz Celia , Hobani Yahya Hasan , Mohan Syam , Goyal Amit , Katyal Taruna , Solarska Ewa , Bungau Simona
Published: September 2021

Adductomics novel and emerging discipline in the toxicological research emphasizes on adducts formed by reactive chemical agents with biological molecules in living organisms. Development in analytical methods propelled the application and utility of adductomics in interdisciplinary sciences. This review endeavors to add a new dimension where comprehensive insights into diverse applications of adductomics in addressing some of society’s pressing challenges are provided. Also focuses on diverse applications of adductomics include: forecasting risk of chronic diseases triggered by reactive agents and predicting carcinogenesis induced by tobacco smoking; assessing chemical agents’ toxicity and supplementing genotoxicity studies; designing personalized medication and precision treatment in cancer chemotherapy; appraising environmental quality or extent of pollution using biological systems; crafting tools and techniques for diagnosis of diseases and detecting food contaminants; furnishing exposure profile of the individual to electrophiles; and assisting regulatory agencies in risk assessment of reactive chemical agents. Characterizing adducts that are present in extremely low concentrations is an exigent task and more over absence of dedicated database to identify adducts is further exacerbating the problem of adduct diagnosis. In addition, there is scope of improvement in sample preparation methods and data processing software and algorithms for accurate assessment of adducts.
Eosinophils as Drivers of Severe Eosinophilic Asthma: Endotypes or Plasticity?
Authors: Van Hulst Glenn , Bureau Fabrice , Desmet Christophe J.
Published: September 2021

Asthma is now recognized as a heterogeneous disease, encompassing different phenotypes driven by distinct pathophysiological mechanisms called endotypes. Common phenotypes of asthma, referred to as eosinophilic asthma, are characterized by the presence of eosinophilia. Eosinophils are usually considered invariant, terminally differentiated effector cells and have become a primary therapeutic target in severe eosinophilic asthma (SEA) and other eosinophil-associated diseases (EADs). Biological treatments that target eosinophils reveal an unexpectedly complex role of eosinophils in asthma, including in SEA, suggesting that “not all eosinophils are equal”. In this review, we address our current understanding of the role of eosinophils in asthma with regard to asthma phenotypes and endotypes. We further address the possibility that different SEA phenotypes may involve differences in eosinophil biology. We discuss how these differences could arise through eosinophil “endotyping”, viz. adaptations of eosinophil function imprinted during their development, or through tissue-induced plasticity, viz. local adaptations of eosinophil function through interaction with their lung tissue niches. In doing so, we also discuss opportunities, technical challenges, and open questions that, if addressed, might provide considerable benefits in guiding the choice of the most efficient precision therapies of SEA and, by extension, other EADs.
Wound Healing Effect of Gintonin Involves Lysophosphatidic Acid Receptor/Vascular Endothelial Growth Factor Signaling Pathway in Keratinocytes
Authors: Choi Sun-Hye , Won Kyung-Jong , Lee Rami , Cho Han-Sung , Hwang Sung-Hee , Nah Seung-Yeol
Published: September 2021

Gintonin, a novel compound of ginseng, is a ligand of the lysophosphatidic acid (LPA) receptor. The in vitro and in vivo skin wound healing effects of gintonin remain unknown. Therefore, the objective of this study was to investigate the effects of gintonin on wound healing-linked responses, especially migration and proliferation, in skin keratinocytes HaCaT. In this study, 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide assay, Boyden chamber migration assay, scratch wound healing assay, and Western blot assay were performed. A tail wound mouse model was used for the in vivo test. Gintonin increased proliferation, migration, and scratch closure in HaCaT cells. It also increased the release of vascular endothelial growth factor (VEGF) in HaCaT cells. However, these increases, induced by gintonin, were markedly blocked by treatment with Ki16425, an LPA inhibitor, PD98059, an ERK inhibitor, 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis (acetoxymethyl ester), a calcium chelator, and U73122, a PLC inhibitor. The VEGF receptor inhibitor axitinib also attenuated gintonin-enhanced HaCaT cell proliferation. Gintonin increased the phosphorylation of AKT and ERK1/2 in HaCaT cells. In addition, gintonin improved tail wound healing in mice. These results indicate that gintonin may promote wound healing through LPA receptor activation and/or VEGF release-mediated downstream signaling pathways. Thus, gintonin could be a beneficial substance to facilitate skin wound healing.
Implementing Mass Rearing of Trissolcus japonicus (Hymenoptera: Scelionidae) on Cold-Stored Host Eggs
Authors: Bittau Barbara , Dindo Maria Luisa , Burgio Giovanni , Sabbatini-Peverieri Giuseppino , Hoelmer Kim Alan , Roversi Pio Federico , Masetti Antonio
Published: September 2021

Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), a pest of Asian origin, has been causing severe damage to Italian agriculture. The application of classical biological control by the release of Trissolcus japonicus (Ashmead) (Hymenoptera: Scelionidae), an exotic egg parasitoid, appears to be one promising solution. In Italy, releases of T. japonicus in the field were authorized in 2020. In this study, some parameters that could influence the rearing of T. japonicus in insectaries were investigated. A significantly higher production of progeny was observed on host eggs stored at 6 °C (86.5%) compared to −24 °C (48.8%) for up to two months prior to exposure to parasitism. There were no significant differences in progeny production from single females in a vial provided with only one egg mass (83.2%) or 10 females inside a cage with 6 egg masses (83.9%). The exposure of parasitoids to refrigerated (6 °C) egg masses of H. halys for 72 h led to a significantly higher production of progeny (62.1%) compared to shorter exposures for 48 (44.0%) or 24 h (37.1%). A decline in production of progeny by the same female was detected between the first (62.1%) and the second parasitization (41.3%). Adult parasitoids stored at 16 °C for up to 90 days had an 87.1% survival rate, but a significant decrease in progeny production was detected. These parameters could be adjusted when rearing T. japonicus for specific aims such as the production of individuals for field release or colony maintenance.
Beewatching: A Project for Monitoring Bees through Photos
Authors: Flaminio Simone , Ranalli Rosa , Zavatta Laura , Galloni Marta , Bortolotti Laura
Published: September 2021

Bees play a key role in natural and agro-ecosystems and their diversity is worldwide threatened by anthropogenic causes. Despite this, there is little awareness of the existence of the numerous species of wild bees, and the common name “bee” is very often exclusively associated with Apis mellifera. Our aim was to create a citizen science project in Italy with the following objectives: (a) raising awareness of the importance and diversity of bees, (b) obtaining data on the biology, ecology and distribution of Italian species, and (c) launching the monitoring of alien bees. The first step of the project was to create a website platform with a section containing informative datasheets of the wild bee families and of the most common bee genera present in Italy, a form to send reports of observed bees and an interactive map with all citizen’s reports. During the 2 years of the project 1086 reports were sent by 269 users, with 38 Apoidea genera reported on 190 plant genera; furthermore, 22 reports regarding the alien species Megachile sculpturalis arrived. The majority of bees (34 genera) were observed on spontaneous plants, including 115 genera native to Italy. Considering the increasing number of reports and data obtained in these first two years of the project, our objectives seem to be achieved. Future steps will be to outline the profile of beewatchers, to plan activities in a more targeted way, and also to start some sub-projects for conservation purposes.
Honeybee Cognition as a Tool for Scientific Engagement
Authors: Denton Jai A. , Koludarov Ivan , Thompson Michele , Bryk Jarosław , Velasque Mariana
Published: September 2021

Apis mellifera (honeybees) are a well-established model for the study of learning and cognition. A robust conditioning protocol, the olfactory conditioning of the proboscis extension response (PER), provides a powerful but straightforward method to examine the impact of varying stimuli on learning performance. Herein, we provide a protocol that leverages PER for classroom-based community or student engagement. Specifically, we detail how a class of high school students, as part of the Ryukyu Girls Outreach Program, examined the effects of caffeine and dopamine on learning performance in honeybees. Using a modified version of the PER conditioning protocol, they demonstrated that caffeine, but not dopamine, significantly reduced the number of trials required for a successful conditioning response. In addition to providing an engaging and educational scientific activity, it could be employed, with careful oversight, to garner considerable reliable data examining the effects of varying stimuli on honeybee learning.
Progressive Fatigue Failure Analysis of a Filament Wound Ring Specimen with a Hole
Authors: Hugaas Eivind , Vedvik Nils Petter , Echtermeyer Andreas T.
Published: September 2021

A progressive FEA mechanical fatigue degradation model for composites was developed and implemented using a UMAT user material subroutine in Abaqus. Numerical results were compared to experimental strain field data from high frequency digital image correlation (DIC) of split disk fatigue testing of pressure vessel cut outs with holes. The model correctly predicted the onset and evolution of damage in the matrix as well as the onset of fiber failure. The model uses progressive failure analysis based on the maximum strain failure criterion, the cycle jump method, and Miner’s sum damage accumulation rule. A parameter study on matrix properties was needed to capture the scatter in strain fields observed experimentally by DIC. S-N curve for the matrix material had to be lowered by 0% to 60% to capture the experimental scatter. The onset of local fiber failure had to be described by local S-N curves measured by DIC having 2.5 times greater strain than that of S-N curves found from standard coupon testing.
Deep-Learning-Based Smartphone Application for Self-Diagnosis of Scleral Jaundice in Patients with Hepatobiliary and Pancreatic Diseases
Authors: Park Joon Hyeon , Yang Min Jae , Kim Ji Su , Park Bumhee , Kim Jin Hong , Sunwoo Myung Hoon
Published: September 2021

Outpatient detection of total bilirubin levels should be performed regularly to monitor the recurrence of jaundice in hepatobiliary and pancreatic disease patients. However, frequent hospital visits for blood testing are burdensome for patients with poor medical conditions. This study validates a novel deep-learning-based smartphone application for the self-diagnosis of scleral jaundice in such patients. The system predicts total serum bilirubin levels using the deep-learning-based regression analysis of scleral photos taken by the smartphone’s built-in camera. Enrolled patients were randomly assigned to either the training cohort (n = 90, 1034 photos) or the validation cohort (n = 40, 426 photos). The intraclass correlation coefficient value for predicted serum total bilirubin (PSB) derived from the images repeatedly taken at the same time for the same patient showed good reliability (0.86). A strong correlation between measured serum total bilirubin (MSB) and PSB was observed in the subgroup with MSB levels ≥1.5 mg/dL (Spearman rho = 0.70, p < 0.001). The receiver operating characteristic curve for PSB showed that the area under the curve was 0.93, demonstrating good test performance as a predictor of hyperbilirubinemia (p < 0.001). Using a cut-off PSB ≥1.5, the prediction sensitivity of hyperbilirubinemia was 80.0%, with a specificity of 92.6%. Hence, the tool is effective for patient monitoring.
The Effects of Different Types of Dual Tasking on Balance in Healthy Older Adults
Authors: de Barros Graça Monteiro , Melo Filipe , Domingos Josefa , Oliveira Raul , Silva Luís , Fernandes Júlio Belo , Godinho Catarina
Published: September 2021

Numerous of our daily activities are performed within multitask or dual task conditions. These conditions involve the interaction of perceptual and motor processes involved in postural control. Age-related changes may negatively impact cognition and balance control. Studies identifying changes related to dual-task actions in older people are need. This study aimed to determine the effects of different types of dual-tasking on the balance control of healthy older adults. The sample included 36 community-living older adults, performing two tests—a sway test and a timed up-and-go test—in three conditions: (a) single motor task; (b) dual motor task; and (c) dual motor task with cognitive demands. Cognitive processes (dual-task and cognition) affected static balance, increasing amplitude (p < 0.001) and frequency (p < 0.001) of the center of mass displacements. Dynamic balance revealed significant differences between the single motor condition and the other two conditions during gait phases (p < 0.001). The effect of dual-tasking in older adults suggests that cognitive processes are a main cause of increased variability in balance and gait when under an automatic control. During sit-to-stand, turning, and turn-to-sit movements under dual-tasking, the perceptive information becomes the most important focus of attention, while any cognitive task becomes secondary.
Feature Explanations in Recurrent Neural Networks for Predicting Risk of Mortality in Intensive Care Patients
Authors: Na Pattalung Thanakron , Ingviya Thammasin , Chaichulee Sitthichok
Published: September 2021

Critical care staff are presented with a large amount of data, which made it difficult to systematically evaluate. Early detection of patients whose condition is deteriorating could reduce mortality, improve treatment outcomes, and allow a better use of healthcare resources. In this study, we propose a data-driven framework for predicting the risk of mortality that combines high-accuracy recurrent neural networks with interpretable explanations. Our model processes time-series of vital signs and laboratory observations to predict the probability of a patient’s mortality in the intensive care unit (ICU). We investigated our approach on three public critical care databases: Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III), MIMIC-IV, and eICU. Our models achieved an area under the receiver operating characteristic curve (AUC) of 0.87–0.91. Our approach was not only able to provide the predicted mortality risk but also to recognize and explain the historical contributions of the associated factors to the prediction. The explanations provided by our model were consistent with the literature. Patients may benefit from early intervention if their clinical observations in the ICU are continuously monitored in real time.
Facile Microwave Hydrothermal Synthesis of ZnFe2O4/rGO Nanocomposites and Their Ultra-Fast Adsorption of Methylene Blue Dye
Authors: Wang En-Rui , Shih Kun-Yauh
Published: September 2021

The industry development in the last 200 years has led to to environmental pollution. Dyes emitted by pharmaceutical and other industries are major organic pollutants. Organic dyes are a pollutant that must be removed from the environment. In this work, we adopt a facile microwave hydrothermal method to synthesize ZnFe2O4/rGO (ZFG) adsorbents and investigate the effect of synthesis temperature. The crystal structure, morphology, chemical state, and magnetic property of the nanocomposite are investigated by X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, and a vibrating sample magnetometer. Furthermore, the synthesized ZFGs are used to remove methylene blue (MB) dye, and the adsorption kinetics, isotherm, mechanism, and reusability of this nanomaterial are studied. The optimal ZFG nanocomposite had a dye removal percentage of almost 100%. The fitting model of adsorption kinetics followed the pseudo-second-order model. The isotherm model followed the Langmuir isotherm and the theoretical maximum adsorption capacity of optimal ZFG calculated by this model was 212.77 mg/g. The π–π stacking and electrostatic interaction resulted in a high adsorption efficiency of ZFG for MB adsorption. In addition, this nanocomposite could be separated by a magnet and maintain its dye removal percentage at almost 100% removal after eight cycles, which indicates its high suitability for utilization in water treatment.
Influence of Local Temperature Changes on the Material Microstructure in Abrasive Water Jet Machining (AWJM)
Authors: Spadło Sławomir , Bańkowski Damian , Młynarczyk Piotr , Hlaváčová Irena M.
Published: September 2021

This article considers effects of local heat transfer taking place insteel cutting by abrasive water jet machining (AWJM). The influence of temperature changes during AWJM has not been investigated thoroughly. Most studies on AWJM suggest that thermal energy has little or no effect on the material cut. This study focused on the analysis of the material microstructure and indentation microhardness in the jet impact zone and the adjacent area. The structure features revealed through optical metallography and scanning microscopy suggest local temperature changes caused by the impact of the abrasive water jet against the workpiece surface. From the microscopic examinationand hardness tests, it is clear that, during the process, large amounts of energy were transferred locally. The mechanical stress produced by the water jet led to plastic deformation at and near the surface. This was accompanied by the generation and transfer of large amounts of heat resulting in a local rise in temperature to 450 °C or higher.
Pyridine Derivatives—A New Class of Compounds That Are Toxic to E. coli K12, R2–R4 Strains
Authors: Koszelewski Dominik , Ostaszewski Ryszard , Śmigielski Paweł , Hrunyk Anastasiia , Kramkowski Karol , Laskowski Łukasz , Laskowska Magdalena , Lizut Rafał , Szymczak Mateusz , Michalski Jacek , Gawin Kamil , Kowalczyk Paweł
Published: September 2021

A preliminary study of 2-amino-4-aryl-3,5-dicarbonitrile-6-thiopyridines as new potential antimicrobial drugs was performed. Special emphasis was placed on the selection of the structure of target pyridine derivatives with the highest biological activity against different types of Gram-stained bacteria by lipopolysaccharide (LPS). Herein, Escherichia coli model strains K12 (without LPS in its structure) and R2–R4 (with different lengths of LPS in its structure) were used. Studied target compounds were provided with yields ranging from 53% to 91% by the lipase-catalyzed one pot multicomponent reaction of various aromatic aldehydes with malononitrile, and thiols. The presented work showed that the antibacterial activity of the studied pyridines depends on their structure and affects the LPS of bacteria. Moreover, the influence of the pyridines on bacteria possessing smooth and rough LPS and oxidative damage to plasmid DNA caused by investigated compounds was indicated. Additionally, the modification of the bacterial DNA with the tested compounds was performed to detect new potential oxidative damages, which are recognized by the Fpg protein. The obtained damage modification values of the analyzed compounds were compared with the modifications after antibiotics were used in this type of research. The presented studies demonstrate that 2-amino-4-aryl-3,5-dicarbonitrile-6-thiopyridines can be used as substitutes for known antibiotics. The observed results are especially important in the case of the increasing resistance of bacteria to various drugs and antibiotics.
Rheology of Alkali-Activated Blended Binder Mixtures
Authors: Tekle Biruk Hailu , Hertwig Ludwig , Holschemacher Klaus
Published: September 2021

Alkali-activated cement (AAC) is an alternative cement that has been increasingly studied over the past decades mainly because of its environmental benefits. However, most studies are on heat-cured AACs and are focused on mechanical properties. There is a lack of research on the fresh properties of ambient-cured AAC systems. This study investigates the rheological properties of ambient-temperature-cured alkali-activated blended binder mixtures activated with sodium silicate and sodium hydroxide solutions. The influence of binder amount, alkaline solid to binder ratio (AS/B), sodium silicate to sodium hydroxide solids ratio (SS/SH), and total water content to total solid (from the binding materials) ratio (TW/TS) on the rheological properties are investigated. The effect of borax as an admixture and silica fume as a replacement for fly ash is also investigated. The results showed that both the yield stress and plastic viscosity are mainly affected by the binder content and TW/TS ratio decreasing with the increase of each parameter. The yield stress increased with the increase of the SS/SH ratio. Borax significantly reduced the yield stress, while silica fume’s effect was dependent on its dosage.
High Strain Rate Yielding of Additive Manufacturing Inconel 625 by Selective Laser Melting
Authors: Du Kang , Yang Laixia , Xu Chao , Wang Bin , Gao Yang
Published: September 2021

Nickel-based alloy Inconel 625, produced by the selective laser melting method, was studied experimentally for its mechanical performance under strain rate loading using Hopkinson bars. Both compression and tensile tests were carried out, with the former also being conducted at 500 °C. The strain rate was in the range of 300 to 3500 s−1 at ambient temperature, and 1200 to 3500 s−1 at the elevated temperature, respectively, for compression tests, and 900 to 2400 s−1 for tensile tests. Results show that the alloy has a strong rate sensitivity with the dynamic yield stress at 3500 s−1, almost doubling the quasistatic value. The test results also show that, even though the temperature elevation leads to material softening, the strain rate effect is still evidential with the dynamic compressive yield stress at the rate 103 s−1 and 500 °C still being higher than the quasistatic one at ambient temperature. It is also observed that dynamic tensile strengths are generally higher than those of compressive ones at room temperature.
Durability of a New Thermal Aerogel-Based Rendering System under Distinct Accelerated Aging Conditions
Authors: Maia Joana , Pedroso Marco , Ramos Nuno M. M. , Flores-Colen Inês , Pereira Pedro F. , Silva Luís
Published: September 2021

The widespread application of innovative thermal enhanced façade solutions requires an adequate durability evaluation. The present work intends to assess the durability of a new aerogel cement-based rendering system through the adaptation of different accelerated aging cycles, such as heating–freezing, freeze–thawing, and heat–cold. Several mechanical properties and also capillary and liquid water absorptions were tested for uncoated and coated specimens. A decrease in the mechanical strength, especially after freeze–thaw cycles, was observed. However, the water action promoted the late hydration of the cement paste contributing to the densification of the matrix and, consequently, the increase of the adhesive strength. Additionally, a decrease in the dynamic modulus of elasticity and an increase in the Poisson’s ratio were observed after aging, which indicates a higher capacity of the render to adapt to substrate movements, contributing to a reduction of cracking.
Effect of Novel Bioactive Glass-Containing Dentin Adhesive on the Permeability of Demineralized Dentin
Authors: Kim Hyun-Jung , Jang Ji-Hyun , Woo Sang Uk , Choi Kyoung-Kyu , Kim Sun-Young , Ferracane Jack L. , Lee Jung-Hwan , Choi Dongseok , Choi Samjin , Kim Soogeun , Bang Ayoung , Kim Duck-Su
Published: September 2021

This study aimed to evaluate the effect of a novel bioactive glass (BAG)-containing dentin adhesive on the permeability of demineralized dentin. Bioactive glass (85% SiO2, 15% CaO) was fabricated using the sol-gel process, and two experimental dentin adhesives were prepared with 3 wt% silica (silica-containing dentin adhesive; SCA) or BAG (BAG-containing dentin adhesive; BCA). Micro-tensile bond strength (μTBS) test, fracture mode analysis, field-emission scanning electron microscopy (FE-SEM) analysis of adhesive and demineralized dentin, real-time dentinal fluid flow (DFF) rate measurement, and Raman confocal microscopy were performed to compare SCA and BCA. There was no difference in μTBS between the SCA and BCA (p > 0.05). Multiple precipitates were evident on the surface of the BCA, and partial occlusion of dentinal tubules was observed in FE-SEM of BCA-approximated dentin. The DFF rate was reduced by 50.10% after BCA approximation and increased by 6.54% after SCA approximation. Raman confocal spectroscopy revealed an increased intensity of the hydroxyapatite (HA) peak on the dentin surface after BCA application. The novel BAG-containing dentin adhesive showed the potential of both reducing dentin permeability and dentin remineralization.
Mechanical Properties of Basalt-Based Recycled Aggregate Concrete for Jeju Island
Authors: Choi Hong-Beom , Park Jin-O , Kim Tae-Hyun , Lee Kyeo-Re
Published: September 2021

Recycled aggregate is essential to protect Jeju Island’s natural environment, but waste concrete, including porous basalt, is a factor that lowers the quality of recycled aggregate. Therefore, an experiment was conducted to analyze the properties of concrete application of basalt-based recycled aggregate (B-RA) through quality improvement. The absorption of the B-RA ranged from 3–5%; restricting its absorption to less than 3% was challenging owing to its porosity and irregular shape. However, the increase in the solid volume percentage of the concrete when replacing 25 or 50% of fresh basalt aggregate with recycled basalt aggregate improved the mechanical performance of the concrete, especially at 25%, for which a compressive strength of 55.9 MPa and modulus of elasticity of 25.9 GPa exceeded those of concrete with fresh basalt aggregate. Moreover, increasing the replacement ratio of the fresh basalt with recycled aggregate reduced the slump and decreased the air content, consequently increasing the concrete drying shrinkage. However, the replacement of fresh basalt aggregate with recycled basalt aggregate unaltered the mechanical performance of the concrete. The results indicate that efficient use of recycled aggregates can yield superior performance to that of fresh basalt, irrespective of aggregate quality.
Internet marketing as a tool for promoting market services in the hospitality and hotel industry
Authors: Glagoleva L.E. , Zatsepilina N.P. , Kovaleva E.N. , Zatsepilina L.S. , Sandberg A.B. , Sekhniev M.E.
Published: September 2021

The article reveals the possibilities of effective use of Internet marketing as a tool to improve the efficiency of market services in the field of hospitality and hotel business. The ways of increasing user interest in Internet projects of enterprises in the hospitality industry and raising the conversion rate of an Internet project through contextual advertising and other ways to boost traffic are considered.
Russia and the WTO: the agro-industrial aspect
Authors: Vavilova E. V.
Published: September 2021

This article deals with actual problem for Russia — food market conditions and the problem of ensuring food security of the country in the current conditions, with the entry of Russia into WTO. The article analyzes the changes in the development of the Russian food market and food security of Russia as a WTO member, and also there proposed measures on reduction of losses from negative consequences of Russia’s accession to this organization
Impact of customs payments on the development of manufacturing industries within the framework of import substitution
Authors: Zhoglicheva Veronika Vladimirovna
Published: September 2021

Develop a strategy of import substitution in the manufacturing industry, aimed at creating a competitive hightech industries, should be implemented at the enterprises of the domestic industry at the expense of own and borrowed funds investors, with the introduction of a series of restrictive measures of state regulation of TTR in order to protect the domestic market from foreign products with high added value. Customs payments must serve as a stimulus for the development of its own domestic industry. Effective use of the tools of customs and tariff regulation should be an important factor for economic development and a necessary condition for the existence of a strong state.
Economic consequences of the Russian food embargo (meat and meat products)
Authors: Svinukhov Vladimir Gennadievich , Senotrusova Svetlana Valentinovna
Published: September 2021

In work the estimation of the volume and value of imports of product group 02 unified Foreign Economic Activity Commodity Nomenclature of the Eurasian Economic Union (FEACN of the EEU) under embargo. For evaluation, we used data external trade statistics of the customs service of the Russian Federation. The analysis showed that the product group 02 FEACN of the EEU were imported with a certain periodicity. It is noted that the reduction of customs duty payment in 2014 relative to 2013 was $500 million.
The role of innovative development in improving the efficiency of the agroindustrial complex
Authors: Omarov Ruslan Bilalovich , Makarova Irina Gennadievna
Published: September 2021

Considering the import substitution and the revival of Russian agricultural production agro-industrial enterprises innovative development and increase of their effectiveness is a topical issue nowadays. The article is devoted to the agro-industrial complex’s innovative investment strategy aimed at the effective development of innovative activity and the production process acceleration in agriculture.
JUSTICIA TRANSICIONAL
Authors: Pérez-Mar Audonatilo
Published: September 2021

En cada nación se identifican elementos de conflictos que aluden a vulnerar o violar derechos humanos transgrediendo la dignidad de la persona. El sistema de administración de justicia debe considerar elementos sustanciales para dar respuesta de forma eficaz y pronta a la misma. En ese sentido, el reconocimiento y validez de las normas de origen externo e interno dan pauta para ejercer y garantizar los derechos reconocidos en la carta magna del estado mexicano. En ese sentido, el presente documento aborda de forma descriptiva aspectos generales de la justicia transicional que tiene por objeto de que los responsables acrediten la responsabilidad de sus actos, exista justicia y se logre la reconciliación; para ello, el sistema de justicia interno debe tener una coalición en los mecanismos de acceso y administración de justicia heterocompositiva y autocompositiva.
COOPERATIVAS HABITACIONAIS COMO INCORPORADORAS IMOBILIÁRIAS: UM ESTUDO A PARTIR DA ESTRUTURA NORMATIVA BRASILEIRA
Authors: Roncato Bruna Silveira , Roncato Onofre , Aguiar Filho Valfredo de Andrade
Published: September 2021

O presente trabalho tem como tema a incorporação imobiliária, tendo sido delimitado na possibilidade das cooperativas habitacionais atuarem como incorporadoras imobiliárias. Como é de conhecimento público, o Brasil é um país que possui um forte déficit habitacional, e portanto, uma parcela significativa da população tem dificuldade de ter acesso à moradia. Uma possível alternativa seria a atuação das cooperativas habitacionais como incorporadoras imobiliárias, criando, administrando e negociando unidades habitacionais autônomas. O problema da pesquisa é qual a estrutura normativa brasileira para formação de cooperativas habitacionais como incorporadoras imobiliárias? A pesquisa é do tipo monográfico, a estrutura do texto é dedutiva, os dados documentais foram analisados pelo método hermenêutico exegético.
ESTIMATION OF THE EFFICIENCY OF THE REGENERATIVE HY-DRAULIC DRIVE FORESTRY TRACTOR WITH DISCOVER TRAILER
Authors:   Voronezh State University of Forestry and Technologies named after G.F. Morozov, Posmetev V.I.
Published: September 2021

Substantiated the actual direction of increasing the efficiency of timber road transport, which consists in the development and use in its design of recuperative mechanisms based on various methods of conversion and accumulation of compressed gas energy. A promising recuperative hydraulic drive of a timber tractor with a dismantling trailer has been proposed. A preliminary assessment of the operation of the mechanism for converting the energy of the working fluid into the energy of compressed gas has been carried out on the basis of simulation.
MODELING THE IMPACT OF WIDE-PROFILE TRUCK TIRES ON THE ROAD SURFACE
Authors:   Voronezh State University of Forestry and Technologies named after G.F. Morozov, Pryadkin V.I. , Shavirin K.A. ,   Voronezh State University of Forestry and Technologies named after G.F. Morozov, Kolcov A.Yu. ,   Voronezh State University of Forestry and Technologies named after G.F. Morozov
Published: September 2021

The article presents a mathematical model of the destructive effect of a wide-profile tire on the roadway. The mathematical model makes it possible to adequately reproduce the effect of a wide-profile tire on the road surface, taking into account the load and parameters of the tire, as well as the structure of the road surface and the temperature state.
THE METHOD OF TWO-PHASE MIXTURE FORMATION IN THE AUTOMOTIVE DIESEL ENGINE AND THE DEVICE FOR ITS IMPLEMENTATION
Authors:   Penza State Agrarian University, Russian Federation, Dubin М.D. , Ryblov М.V. ,   Penza State Agrarian University, Russian Federation
Published: September 2021

The article offers the method of improving of the automotive diesel engine power capacity, fuel economy and ecological parameters by two-phase mixture formation. In this way, the first phase is performed by means of the fuel activator supply (dose 10-20 %) into the intake manifold. The second phase is performed by means of the main fuel dose by the standard fuel system. The design of the developed system for the implementation of the first phase of two-phase mixture formation is described.
IMPROVEMENT OF THE TECHNOLOGY FOR PRODUCING PLAIN BEARINGS FROM MODIFIED WOOD USING THE SNS-03 SECTOR CUTTING MACHINE
Authors:   Voronezh State University of Forestry and Technologies Named after G.F. Morozov, Shamaev V.A. , Chelebadze I.Z. ,   Voronezh State University of Forestry and Technologies named after G.F. Morozov
Published: September 2021

The article presents a method for improving the technology of obtaining sliding bearings from modified wood by automating the cutting of sectors on the basis of the SNS-03 machine.
Dispossession: Plundering German Jewry, 1933-1953
Authors: Huang Yu
Published: September 2021

Christoph Kreuzmüller and Jonathan R. Zatlin (Eds.)
Menschen im Weltgarten: Die Entdeckung der Ökologie in der Literatur von Haller bis Humboldt
Authors: Stephan Sigmund Jakob-Michael
Published: September 2021

Heinrich Detering (author)
Fictions of Legibility. The Human Face and Body in Modern German Novels from Sophie von La Roche to Alfred Döblin
Authors: Finkenstein Franzi
Published: September 2021

Gabriela Stoicea (author)
USE OF DIGITAL TECHNOLOGIES IN HIGHER EDUCATIONAL INSTITUTIONS
Authors: Глузман Н. А. , Шпиталевская Г. Р.
Published: September 2021

В статье рассматриваются вопросы цифровизации образования и технологий ее внедрения в высших учебных заведениях. В первую очередь отметим, что основой образовательного процесса является овладение содержанием обучения и на его основе внедрение образовательных технологий, методики обучения. Особую роль в этом процессе играют инновационные технологии обучения. В частности, осуществление смешанного обучения с использованием онлайн-технологий. Важную роль играет реализация мотивации к обучению, так как в основе ее лежит самостоятельная работа соискателей высшего образования. Сейчас широкое распространение получило дуальное обучение, которое осуществляется в высших учебных заведениях по определенным моделям и технологиям. Это актуализирует потребность в современных условиях на рынке труда специалистов, имеющих высокий уровень информированности и способности осваивать новые знания, решать профессиональные задачи.

The article discusses the issues of digitalization of education, the technologies for its implementation in higher educational institutions. First of all, we note that mastering the content of education and, on its basis, the inculcation of educational technologies and teaching methods - is the basis of the educational process. In this process innovative teaching technologies play a special role. In particular, it means the implementation of mixed education using online technologies. Learning motivation plays an important role as the independent work of applicants for higher education is based on it. Nowadays, dual education has become widespread, it is carried out in higher educational institutions according to certain models and technologies. Under modern conditions in the labor market this actualizes the demand for specialists with a high level of awareness and the ability to master new knowledge and solve professional problems.
SYSTEMS FOR MONITORING TRENDS IN THE DEVELOPMENT OF DISTANCE LEARNING
Authors: Алисултанова Э. Д. , Магомадова А. Р. , Мусаева М. С-М.
Published: September 2021

В статье отражены актуальные проблемы, связанные с развитием дистанционного образования в России. В частном порядке были рассмотрены такие темы, как влияние текущей мировой пандемии, вызванной коронавирусом COVID-19, на ускоренное развитие дистанционного обучения, приведена статистика, были отмечены основные плюсы и минусы дистанционного образования в целом, приведена классификация основных функциональных элементов процесса реализации дистанционного обучения, дано понятие мониторинга, приведены примеры реализации систем мониторинга при помощи инструментов с открытым исходным кодом. Доказано, что для успешной реализации обучения на расстоянии необходимо взаимодействие преподавателя и студента, актуальное обновление обучающих курсов, поддержка единого веб-портала для выкладывания свежих материалов. В статье автор предложил пути и способы оптимизации процесса мониторинга систем, предоставив актуальную классификацию систем, а также пример входных данных, на основе которых делается статистика.

The article reflects the current problems associated with the development of distance education in Russia. Topics such as the impact of the current global pandemic caused by the COVID-19 coronavirus on the accelerated development of distance learning were discussed in private, statistics were provided, the main pros and cons of distance education in general were noted, the classification of the main functional elements of the distance learning implementation process was given, the concept of monitoring was given, examples of the implementation of monitoring systems using open source tools were given. It was suggested that the most important component of the successful implementation of distance learning is the interaction of the teacher and the student, the actual updating of training courses, the support of a single web portal for posting fresh materials. In the article, the author proposed ways and means of optimizing the process of monitoring systems, providing an up-to-date classification of systems, as well as an example of input data on the basis of which statistics are made.
INFORMATION AND INFORMATION AND COMPUTER TECHNOLOGIES IN THE CONTEXT OF MODERN SCIENTIFIC KNOWLEDGE
Authors: Келигов М. Ю.
Published: September 2021

В статье освещается динамика информационно-компьютерных технологий, рассмотренных через призму кибернетических взглядов Н. Винера. Кибернетика трактуется как теория организации и теория борьбы с мировым хаосом, с роковым возрастанием энтропии. Современные коммуникационные технологии представлены не как спокойное течение, а как поток сообщений, проходящий в атмосфере противоречий и рисков. Показана информационная действенность интернета, характеризуется сущность современного потребительского общества, реализован критический подход к базовым понятиям «знание» и «информация».

The article highlights the dynamics of information and computer technologies considered through the prism of N. Wiener's cybernetic views. Cybernetics is interpreted as a theory of organization and a theory of struggle against world chaos, with a fatal increase in entropy. Modern communication technologies are presented not as a calm flow, but as a flow of messages passing in an atmosphere of contradictions and risks. The informational effectiveness of the Internet is shown, the essence of the modern consumer society is characterized, a critical approach to the basic concepts of "knowledge" and "information" is implemented.
REGIONAL ECONOMY: CONTEMPORARY GOVERNANCE CONDITIONS
Authors: Бетирсултанов А. Н. , Далхадова М. Л. , Мусостова Д. Ш.
Published: September 2021

Национальная экономика - сложно структурированная система, объединяющая в себе различные отраслевые и территориальные подсистемы. Эффективное взаимодействие между различными звеньями национальной экономики обеспечивает сбалансированность развития и положительную динамику макроэкономических показателей. Необходимость формирования теоретической и практической базы для управления территориальной структурой национальной экономики обусловливает актуальность исследования региональной экономики как науки и прикладной дисциплины.

The national economy is a complex structured system that combines various sectoral and territorial subsystems. Effective interaction between various parts of the national economy ensures balanced development and positive dynamics of macroeconomic indicators. The need to form a theoretical and practical basis for managing the territorial structure of the national economy determines the relevance of the study of the regional economy as a science and applied discipline.
Manajemen Risiko: Insiden Kritis Akibat COVID-19 pada Kedai Makanan di Sekitar Kampus Universitas Kristen Petra Surabaya
Authors: Valentina Graciella , Leng Pwee
Published: September 2021

This study aims to determine risk management in the food and beverage business around Petra Christian University (PCU) Surabaya. There was a critical incident of COVID-19 so this research was conducted with the aim of producing reports for business owners related to risk management in business operations. The risk management process consists of stages of risk identification, risk analysis, risk evaluation, and risk management. The population used in this study is food and beverage shop that are easily accessible around PCU with the main target of consumers are students, and PCU employees that is still open the business in the midst of the COVID-19 pandemic. There are only 3 shops out of dozens of food and beverage shops that experienced critical incidents due to PCU implementing online learning which still lasted until this research was conducted. Those risks are spread across 3 different business categories, namely main business process, essential business process, and supporting business process. The majority of risks are in the category of supporting business processes. The same risk can be spread across different risk categories in each foods and beverage shop, this is due to the different risk appetite of each shop.Penelitian ini bertujuan untuk mengetahui manajemen risiko pada bisnis makanan dan minuman di sekitar Universitas Kristen Petra (UKP) Surabaya. Adanya kejadian kritis COVID-19 sehingga penelitian ini dilakukan dengan tujuan untuk menghasilkan laporan bagi pemilik usahaterkait dengan manajemen risiko pada operasional bisnis. Proses manajemen risiko terdiri dari tahapan identifikasi risiko, analisis risiko, evaluasi risiko, dan penanganan risiko. Populasi yang digunakan dalam penelitian ini adalah kedai makanan yang mudah dijangkau di sekitar UKP dengan mayoritas konsumennya mahasiswa, dan karyawan UKP yang masih membuka usaha di tengah pandemi COVID-19. Hanya terdapat 3 kedaimakanan dari beberapa kedai makanan yang mengalami kejadian kritis akibat UKP menerapkan kuliah secara online yang masih bertahan hingga penelitian ini dilakukan. Risiko-risiko tersebut tersebar di 3 kategori bisnis yang berbeda yaitu proses bisnis utama, proses bisnis penunjang, dan proses bisnis pendukung. Mayoritas risiko berada pada kategori proses bisnis pendukung. Risiko yang sama dapat tersebar pada kategori risiko yang berbeda di setiap kedai makanan, hal ini disebabkan oleh selera risiko yang berbeda dari setiap kedai makanan.