bluuebunny/crossref_metadata_2025 huggingface dataset:
A Health-Impact Assessment of an Ergonomic Measure to Reduce the Risk of Work-Related Lower Back Pain, Lumbosacral Radicular Syndrome and Knee Osteoarthritis among Floor Layers in The Netherlands
Authors: Kuijer P. Paul F. M. , van der Molen Henk F. , Visser Steven
Published: March 2023

Sand–cement-bound screed floor layers are at risk of work-related lower back pain, lumbosacral radicular syndrome and knee osteoarthritis, given their working technique of levelling screed with their trunk bent while mainly supported by their hands and knees. To reduce the physical demands of bending of the trunk and kneeling, a manually movable screed-levelling machine was developed for floor layers in the Netherlands. The aim of this paper is to estimate the potential health gains of working with a manually movable screed-levelling machine on the risk of lower back pain (LBP), lumbosacral radicular syndrome (LRS) and knee osteoarthritis (KOA) compared to traditional working techniques. This potential health gain was assessed using the epidemiological population estimates of the Population Attributable Fraction (PAF) and the Potential Impact Fraction (PIF), combined with work-related risk estimates for these three disorders from systematic reviews. The percentage of workers exceeding these risk estimates was based on worksite observations among 28 floor layers. For LBP, 16/18 workers were at risk when using traditional working techniques, with a PAF = 38%, and for those using a manually movable screed-levelling machine, this was 6/10 with a PIF = 13%. For LRS, these data were 16/18 with a PAF = 55% and 14/18 with a PIF = 18%, and for KOA, 8/10 with a PAF = 35% and 2/10 with a PIF = 26%. A manually movable screed-levelling machine might have a significant impact on the prevention of LBP, LRS and KOA among floor layers in the Netherlands, and health-impact assessments are a feasible approach for assessing health gains in an efficient way.
Stand Up for Yourself: Tackling Sedentary Behavior through Exercise and Lifestyle
Authors: Fermino Rogério César , Guerra Paulo Henrique
Published: March 2023

Because of their direct relations to the process of health and disease throughout life, physical activity and sedentary behavior emerge as priorities in the global public health agenda [...]
A Dynamic DEA Analysis of Health Output Efficiencies of Cities and Counties in Taiwan
Authors: Hu Jin-Li , Chuang Min-Yueh , Yeh Shang-Ho
Published: March 2023

This research utilizes the dynamic slack-based measure (DSBM) model to evaluate health output efficiencies in Taiwan’s administrative districts from 2014 to 2018. To measure health output efficiency, it adopts four input variables, one output variable, and one carry-over (exercise expenditure). This paper includes both public goods in totals and private goods per capita as the inputs of health output. Empirical results indicate that health output efficiencies in the south and east areas relatively lower. Lastly, the overall efficiency of urban areas may not be better than that in non-urban areas.
Fertilization and Global Warming Impact on Paddy CH4 Emissions
Authors: Hou Pengfu , Deng Xuzhe , Wang Jing , Xue Lixiang , Zhang Yushu , Xu Tingting , Xue Lihong , Yang Linzhang
Published: March 2023

Introduction: This study aimed to assess the influence of experimental warming and fertilization on rice yield and paddy methane emissions. Methods: A free-air temperature increase system was used for the experimental warming treatment (ET), while the control treatment used ambient temperature (AC). Each treatment contained two fertilization strategies, (i) normal fertilization with N, P and K fertilizers (CN) and (ii) without N fertilizer input (CK). Results: The yield was remarkably dictated by fertilization (p < 0.01), but not warming. Its value with CN treatment increased by 76.24% compared to CK. Also, the interactive effect of warming and fertilization on CH4 emissions was insignificant. The seasonal emissions from warming increased by 36.93% compared to AC, while the values under CN treatment increased by 79.92% compared to CK. Accordingly, the ET-CN treatment obtained the highest CH4 emissions (178.08 kg ha−1), notably higher than the other treatments. Also, the results showed that soil fertility is the main driver affecting CH4 emissions rather than soil microorganisms. Conclusions: Fertilization aggravates the increasing effect of warming on paddy methane emissions. It is a daunting task to optimize fertilization to ensure yield and reduce methane emissions amid global warming.
Identifying the Enablers and Barriers to Advance Nurse Prescribing of Medication in Spain According to Experts’ Views: A Delphi Study
Authors: Gomis-Jimeno Francisco Javier , Lillo-Crespo Manuel
Published: March 2023

Nurses play an important role in pharmaceutical care worldwide in detecting clinical changes, communicating and discussing pharmacotherapy with patients, their families, and other healthcare professionals, proposing and implementing drug-related interventions, and ensuring the monitoring of patients and their medication regimens, among others. However, there is no global consensus across countries regarding the prescribing of medication by nurses. In Spain, for example, this topic is currently in transition since the approval of the Royal Decree 1302/2018 of October 22nd, which regulates the indication, use, and authorization for dispensing human-use medication by nurses. Our study aims to identify the enablers and barriers to advancing the nurse prescribing of medication in Spain through the views of experts in the field and according to the latest Royal Decree approved and the steps taken by the different Spanish autonomous communities. A modified qualitative Delphi study with three iterations was performed online through the perspectives of experts from the field of healthcare education, research, practice, management, and policy. Data extracted from the literature review were used to formulate the open-ended questions utilized in the three rounds. The experts involved (n = 15) belonged to different Spanish regions where the Royal Decree is being implemented with different speeds, and had distinct backgrounds and experiences. Our results highlight the importance of prospectively developing additional protocols based on chronic diseases as well as scaling up towards independent nursing prescription, the inclusion of a joint multidisciplinary pharmaceutical care model, the controversial role played by national nursing councils and boards, the variability in the speed of implementation among the autonomous communities, and the lack of nursing training in the field of medication prescription.
Analysis of the Mental and Physical Health Symptomatology Scale in a Sample of Emerging and Migrant Adults in Chile
Authors: Barrera-Herrera Ana , Baeza-Rivera María José , Salazar-Fernández Camila , Manríquez-Robles Diego
Published: March 2023

Health inequities exist in groups of greater psychosocial vulnerability such as emerging adults and migrants. The study aimed to generate evidence of the validity of the mental and physical health symptomatology scale in two samples of vulnerable groups: emerging university adults, who report high levels of mental health problems, and migrants, who report high levels of physical and mental health problems. Using non-probability sampling, in the first study, evidence of construct validity of the scale was reported in 652 emerging adults and, in the second, evidence of validity was provided from associations with the depression, stress and anxiety scale (DASS-21) among 283 migrants. The results indicate that in Study 1 the two-factor model had adequate indicators of fit and adequate reliability; only the mental health factor presented evidence of convergent validity. In Study 2, the mental health factor showed positive and large associations with the DASS-21, which decreased when the physical health symptoms factor was considered. These analyses provide evidence of validity for the scale, which is an easy-to-use instrument that allows for the assessment of health from an integral perspective.
Indoor Radon Concentration Levels in Healthcare Settings: The Results of an Environmental Monitoring in a Large Italian University Hospital
Authors: De Maria Luigi , Sponselli Stefania , Caputi Antonio , Delvecchio Giuseppe , Giannelli Gianmarco , Pipoli Antonella , Cafaro Francesco , Zagaria Silvia , Cavone Domenica , Sardone Rodolfo , Vimercati Luigi
Published: March 2023

The aim of the study is to determine the radon concentrations in the University Hospital of Bari, Apulia Region, Southern Italy. The monitoring took place from 2017 to 2018 for a total of 402 days and included 3492 premises. Radon environmental sampling was performed with passive dosimeters of the CR-39 type. The highest mean concentration was found in basement rooms (118.9 Bq/m3), followed by ground-floor rooms (88.2 Bq/m3), first-floor rooms (78.1 Bq/m3), second-floor rooms (66.7 Bq/m3), and third-floor rooms (68.9 Bq/m3). An average radon concentration lower than the WHO recommended level of 100 Bq/m3 was detected in 73.5% of monitored environments, while only 0.9% exceeded the reference level of 300 Bq/m3 set by the national law (Legislative Decree 101/2020). The frequency of environments in which radon concentrations exceed 300 Bq/m3 is significantly higher in the basement (p-value < 0.001). As for a previous preliminary investigation in the same hospital conducted on a much smaller number of premises (n = 401), most of the monitored environments had radon concentrations lower than the reference levels set by the new national law, and the risk to the healthcare workers’ health derived from occupational exposure to radon could be considered acceptable.
Big Data Analytics to Reduce Preventable Hospitalizations—Using Real-World Data to Predict Ambulatory Care-Sensitive Conditions
Authors: Schulte Timo , Wurz Tillmann , Groene Oliver , Bohnet-Joschko Sabine
Published: March 2023

The purpose of this study was to develop a prediction model to identify individuals and populations with a high risk of being hospitalized due to an ambulatory care-sensitive condition who might benefit from preventative actions or tailored treatment options to avoid subsequent hospital admission. A rate of 4.8% of all individuals observed had an ambulatory care-sensitive hospitalization in 2019 and 6389.3 hospital cases per 100,000 individuals could be observed. Based on real-world claims data, the predictive performance was compared between a machine learning model (Random Forest) and a statistical logistic regression model. One result was that both models achieve a generally comparable performance with c-values above 0.75, whereas the Random Forest model reached slightly higher c-values. The prediction models developed in this study reached c-values comparable to existing study results of prediction models for (avoidable) hospitalization from the literature. The prediction models were designed in such a way that they can support integrated care or public and population health interventions with little effort with an additional risk assessment tool in the case of availability of claims data. For the regions analyzed, the logistic regression revealed that switching to a higher age class or to a higher level of long-term care and unit from prior hospitalizations (all-cause and due to an ambulatory care-sensitive condition) increases the odds of having an ambulatory care-sensitive hospitalization in the upcoming year. This is also true for patients with prior diagnoses from the diagnosis groups of maternal disorders related to pregnancy, mental disorders due to alcohol/opioids, alcoholic liver disease and certain diseases of the circulatory system. Further model refinement activities and the integration of additional data, such as behavioral, social or environmental data would improve both model performance and the individual risk scores. The implementation of risk scores identifying populations potentially benefitting from public health and population health activities would be the next step to enable an evaluation of whether ambulatory care-sensitive hospitalizations can be prevented.
GeoGraphVis: A Knowledge Graph and Geovisualization Empowered Cyberinfrastructure to Support Disaster Response and Humanitarian Aid
Authors: Li Wenwen , Wang Sizhe , Chen Xiao , Tian Yuanyuan , Gu Zhining , Lopez-Carr Anna , Schroeder Andrew , Currier Kitty , Schildhauer Mark , Zhu Rui
Published: March 2023

The past decade has witnessed an increasing frequency and intensity of disasters, from extreme weather, drought, and wildfires to hurricanes, floods, and wars. Providing timely disaster response and humanitarian aid to these events is a critical topic for decision makers and relief experts in order to mitigate impacts and save lives. When a disaster occurs, it is important to acquire first-hand, real-time information about the potentially affected area, its infrastructure, and its people in order to develop situational awareness and plan a response to address the health needs of the affected population. This requires rapid assembly of multi-source geospatial data that need to be organized and visualized in a way to support disaster-relief efforts. In this paper, we introduce a new cyberinfrastructure solution—GeoGraphVis—that is empowered by knowledge graph technology and advanced visualization to enable intelligent decision making and problem solving. There are three innovative features of this solution. First, a location-aware knowledge graph is created to link and integrate cross-domain data to make the graph analytics-ready. Second, expert-driven disaster response workflows are analyzed and modeled as machine-understandable decision paths to guide knowledge exploration via the graph. Third, a scene-based visualization strategy is developed to enable interactive and heuristic visual analytics to better comprehend disaster impact situations and develop action plans for humanitarian aid.
Finding miRNA–RNA Network Biomarkers for Predicting Metastasis and Prognosis in Cancer
Authors: Lee Seokwoo , Cho Myounghoon , Park Byungkyu , Han Kyungsook
Published: March 2023

Despite remarkable progress in cancer research and treatment over the past decades, cancer ranks as a leading cause of death worldwide. In particular, metastasis is the major cause of cancer deaths. After an extensive analysis of miRNAs and RNAs in tumor tissue samples, we derived miRNA–RNA pairs with substantially different correlations from those in normal tissue samples. Using the differential miRNA–RNA correlations, we constructed models for predicting metastasis. A comparison of our model to other models with the same data sets of solid cancer showed that our model is much better than the others in both lymph node metastasis and distant metastasis. The miRNA–RNA correlations were also used in finding prognostic network biomarkers in cancer patients. The results of our study showed that miRNA–RNA correlations and networks consisting of miRNA–RNA pairs were more powerful in predicting prognosis as well as metastasis. Our method and the biomarkers obtained using the method will be useful for predicting metastasis and prognosis, which in turn will help select treatment options for cancer patients and targets of anti-cancer drug discovery.
A Novel Wall-Associated Kinase TaWAK-5D600 Positively Participates in Defense against Sharp Eyespot and Fusarium Crown Rot in Wheat
Authors: Qi Haijun , Zhu Xiuliang , Shen Wenbiao , Zhang Zengyan
Published: March 2023

Sharp eyespot and Fusarium crown rot, mainly caused by soil-borne fungi Rhizoctonia cerealis and Fusarium pseudograminearum, are destructive diseases of major cereal crops including wheat (Triticum aestivum). However, the mechanisms underlying wheat-resistant responses to the two pathogens are largely elusive. In this study, we performed a genome-wide analysis of wall-associated kinase (WAK) family in wheat. As a result, a total of 140 TaWAK (not TaWAKL) candidate genes were identified from the wheat genome, each of which contains an N-terminal signal peptide, a galacturonan binding domain, an EGF-like domain, a calcium binding EGF domain (EGF-Ca), a transmembrane domain, and an intracellular Serine/Threonine protein kinase domain. By analyzing the RNA-sequencing data of wheat inoculated with R. cerealis and F. pseudograminearum, we found that transcript abundance of TaWAK-5D600 (TraesCS5D02G268600) on chromosome 5D was significantly upregulated, and that its upregulated transcript levels in response to both pathogens were higher compared with other TaWAK genes. Importantly, knock-down of TaWAK-5D600 transcript impaired wheat resistance against the fungal pathogens R. cerealis and F. pseudograminearum, and significantly repressed expression of defense-related genes in wheat, TaSERK1, TaMPK3, TaPR1, TaChitinase3, and TaChitinase4. Thus, this study proposes TaWAK-5D600 as a promising gene for improving wheat broad resistance to sharp eyespot and Fusarium crown rot (FCR) in wheat.
Loss of Blood-Brain Barrier Integrity in an In Vitro Model Subjected to Intermittent Hypoxia: Is Reversion Possible with a HIF-1α Pathway Inhibitor?
Authors: Voirin Anne Cloé , Chatard Morgane , Briançon-Marjollet Anne , Pepin Jean Louis , Perek Nathalie , Roche Frederic
Published: March 2023

Several sleep-related breathing disorders provoke repeated hypoxia stresses, which potentially lead to neurological diseases, such as cognitive impairment. Nevertheless, consequences of repeated intermittent hypoxia on the blood-brain barrier (BBB) are less recognized. This study compared two methods of intermittent hypoxia induction on the cerebral endothelium of the BBB: one using hydralazine and the other using a hypoxia chamber. These cycles were performed on an endothelial cell and astrocyte coculture model. Na-Fl permeability, tight junction protein, and ABC transporters (P-gp and MRP-1) content were evaluated with or without HIF-1 inhibitors YC-1. Our results demonstrated that hydralazine as well as intermittent physical hypoxia progressively altered BBB integrity, as shown by an increase in Na-Fl permeability. This alteration was accompanied by a decrease in concentration of tight junction proteins ZO-1 and claudin-5. In turn, microvascular endothelial cells up-regulated the expression of P-gp and MRP-1. An alteration was also found under hydralazine after the third cycle. On the other hand, the third intermittent hypoxia exposure showed a preservation of BBB characteristics. Furthermore, inhibition of HIF-1α with YC-1 prevented BBB dysfunction after hydralazine treatment. In the case of physical intermittent hypoxia, we observed an incomplete reversion suggesting that other biological mechanisms may be involved in BBB dysfunction. In conclusion, intermittent hypoxia led to an alteration of the BBB model with an adaptation observed after the third cycle.
Swelling of Homogeneous Alginate Gels with Multi-Stimuli Sensitivity
Authors: Malektaj Haniyeh , Drozdov Aleksey D. , deClaville Christiansen Jesper
Published: March 2023

A new two-step method is suggested for the preparation of homogeneous alginate gels. In the first step, alginate chains are weakly bonded by Ca2+ ions in an aqueous solution with a low pH. In the next step, the gel is immersed into a strong solution of CaCl2 to finalize the cross-linking process. Homogeneous alginate gels preserve their integrity in aqueous solutions with a pH ranging from 2 to 7 and ionic strength in the interval from 0 to 0.2 M, at temperatures ranging from room temperature up to 50 °C, and can be used in biomedical applications. The immersion of these gels into aqueous solutions with low pH induces the partial breakage of ionic bonds between chains (treated as gel degradation). This degradation affects the equilibrium and transient swelling of homogeneous alginate gels and makes them sensitive to the history of loading and environmental conditions (pH, ionic strength and temperature of aqueous solutions). As sensitivity to the environmental stimuli is a characteristic feature of polymer networks connected by catch bonds, homogeneous alginate gels may serve as a simple model, mimicking the behavior of more sophisticated structures in living matter.
Modulation of the Tumor Microenvironment by Microbiota-Derived Short-Chain Fatty Acids: Impact in Colorectal Cancer Therapy
Authors: Gomes Sara , Rodrigues Ana Catarina , Pazienza Valerio , Preto Ana
Published: March 2023

Finding new therapeutic approaches towards colorectal cancer (CRC) is of increased relevance, as CRC is one of the most common cancers worldwide. CRC standard therapy includes surgery, chemotherapy, and radiotherapy, which may be used alone or in combination. The reported side effects and acquired resistance associated with these strategies lead to an increasing need to search for new therapies with better efficacy and less toxicity. Several studies have demonstrated the antitumorigenic properties of microbiota-derived short-chain fatty acids (SCFAs). The tumor microenvironment is composed by non-cellular components, microbiota, and a great diversity of cells, such as immune cells. The influence of SCFAs on the different constituents of the tumor microenvironment is an important issue that should be taken into consideration, and to the best of our knowledge there is a lack of reviews on this subject. The tumor microenvironment is not only closely related to the growth and development of CRC but also affects the treatment and prognosis of the patients. Immunotherapy has emerged as a new hope, but, in CRC, it was found that only a small percentage of patients benefit from this treatment being closely dependent on the genetic background of the tumors. The aim of this review was to perform an up-to-date critical literature review on current knowledge regarding the effects of microbiota-derived SCFAs in the tumor microenvironment, particularly in the context of CRC and its impact in CRC therapeutic strategies. SCFAs, namely acetate, butyrate, and propionate, have the ability to modulate the tumor microenvironment in distinct ways. SCFAs promote immune cell differentiation, downregulate the expression of pro-inflammatory mediators, and restrict the tumor-induced angiogenesis. SCFAs also sustain the integrity of basement membranes and modulate the intestinal pH. CRC patients have lower concentrations of SCFAs than healthy individuals. Increasing the production of SCFAs through the manipulation of the gut microbiota could constitute an important therapeutic strategy towards CRC due to their antitumorigenic effect and ability of modulating tumor microenvironment.
Metabolomic and Proteomic Profiling of Porcine Intestinal Epithelial Cells Infected with Porcine Epidemic Diarrhea Virus
Authors: Wang Haifei , Hui Peng , Uemoto Yoshinobu , Ding Yueyun , Yin Zongjun , Bao Wenbin
Published: March 2023

Porcine epidemic diarrhea virus (PEDV) infection results in severe epidemic diarrhea and the death of suckling pigs. Although new knowledge about the pathogenesis of PEDV has been improved, alterations in metabolic processes and the functional regulators involved in PEDV infection with host cells remain largely unknow. To identify cellular metabolites and proteins related to PEDV pathogenesis, we synergistically investigated the metabolome and proteome profiles of PEDV-infected porcine intestinal epithelial cells by liquid chromatography tandem mass spectrometry and isobaric tags for relative and absolute quantification techniques. We identified 522 differential metabolites in positive and negative ion modes and 295 differentially expressed proteins after PEDV infection. Pathways of cysteine and methionine metabolism, glycine, serine and threonine metabolism, and mineral absorption were significantly enriched by differential metabolites and differentially expressed proteins. The betaine-homocysteine S-methyltransferase (BHMT) was indicated as a potential regulator involved in these metabolic processes. We then knocked down the BHMT gene and observed that down-expression of BHMT obviously decreased copy numbers of PEDV and virus titers (p < 0.01). Our findings provide new insights into the metabolic and proteomic profiles in PEDV-infected host cells and contribute to our further understanding of PEDV pathogenesis.
The Impact of Hydroxyapatite Sintering Temperature on Its Microstructural, Mechanical, and Biological Properties
Authors: Trzaskowska Marta , Vivcharenko Vladyslav , Przekora Agata
Published: March 2023

Hydroxyapatite (HA), the principal mineral of bone tissue, can be fabricated as an artificial calcium phosphate (CaP) ceramic and potentially used as bioceramic material for bone defect treatment. Nevertheless, the production method (including the applied sintering temperature) of synthetic hydroxyapatite directly affects its basic properties, such as its microstructure, mechanical parameters, bioabsorbability, and osteoconductivity, and in turn influences its biomedical potential as an implantable biomaterial. The wide application of HA in regenerative medicine makes it necessary to explain the validity of the selection of the sintering temperature. The main emphasis of this article is on the description and summarization of the key features of HA depending on the applied sintering temperature during the synthesis process. The review is mainly focused on the dependence between the HA sintering temperature and its microstructural features, mechanical properties, biodegradability/bioabsorbability, bioactivity, and biocompatibility.
Systemic Lupus Erythematosus and Pulmonary Hypertension
Authors: Parperis Konstantinos , Velidakis Nikolaos , Khattab Elina , Gkougkoudi Evangelia , Kadoglou Nikolaos P. E.
Published: March 2023

Pulmonary Hypertension (PH) is a common manifestation in patients with Systemic Lupus Erythematosus (SLE) and varies from asymptomatic to life-threatening disease. PH can result not only from immune system dysregulation, but also from various conditions, including cardiorespiratory disorders and thromboembolic diseases. Most commonly, SLE-related PH presents with non-specific symptoms, such as progressive dyspnea on exertion, generalized fatigue and weakness and eventually dyspnea at rest. Prompt diagnosis of SLE-related PH and early identification of the underlying pathogenetic mechanisms is demanded in order to introduce targeted therapy to prevent irreversible pulmonary vascular damage. In most cases the management of PH in SLE patients is similar to idiopathic pulmonary arterial hypertension (PAH). Furthermore, specific diagnostic tools like biomarkers or screening protocols, to establish early diagnosis seem to be not available yet. Although, the survival rates for patients with SLE-related PH vary between studies, it is evident that PH presence negatively affects the survival of SLE patients.
Enhanced Learning and Forgetting Behavior for Contextual Knowledge Tracing
Authors: Chen Mingzhi , Bian Kaiquan , He Yizhou , Li Zhefu , Zheng Hua
Published: March 2023

Knowledge tracing (KT) is based on modeling students’ behavior sequences to obtain students’ knowledge state and predict students’ future performance. The KT task aims to model students’ knowledge state in real-time according to their historical learning behavior, so as to predict their future learning performance. Online education has become more critical in recent years due to the impact of COVID-19, and KT has also attracted much attention due to its importance in the education field. However, previous KT models generally have the following three problems. Firstly, students’ learning and forgetting behaviors affect their knowledge state, and past KT models have yet to exploit this fully. Secondly, the input of traditional KT models is mainly limited to students’ exercise sequence and answers. In the learning process, students’ answering performance can reflect their knowledge level. Finally, the context of students’ learning sequence also affects their judgment of the knowledge state. In this paper, we combined educational psychology theories to propose enhanced learning and forgetting behavior for contextual knowledge tracing (LFEKT). LFEKT enriches the features of exercises by introducing difficulty information and considers the influence of students’ answering behavior on the knowledge state. In order to model students’ learning and forgetting behavior, LFEKT integrates multiple influencing factors to build a knowledge acquisition module and a knowledge retention module. Furthermore, LFEKT introduces a long short-term memory (LSTM) network to capture the contextual relations of learned sequences. From the experimental results, it can be seen that LFEKT had better prediction performance than existing models on four public datasets, which indicates that LFEKT can better trace students’ knowledge state and has better prediction performance.
Elicitation of Key Factors to Support Information Technology Outsourcing in Technological Innovation Hubs: Applying a Multicriteria Analytical Framework
Authors: Silva Thalles André Cabral , de Carvalho Victor Diogho Heuer , dos Santos Robério José Rogério , Poleto Thiago , Nepomuceno Thyago Celso Cavalcante
Published: March 2023

This work presents an analytical framework for eliciting key factors for successful relationships between parties in information technology outsourcing (ITO) projects. The proposal was based on a multicriteria analysis to identify key factors within the literature that were essential for the success of projects involving IT outsourcing. Using the multicriteria analysis method PROMETHEE II, the most important key factors were ranked according to the judgment of the managers of the companies in the innovation ecosystem of Alagoas, Brazil. The study was based on thirty-one judgment criteria that, in this case, were formed by the interviewed managers and twenty-one alternatives that were the key factors identified in the literature. This work contributes to composing a reference for the analysis of ITO projects and information governance, informing which factors should be prioritized according to the desired objective of the manager within the project. From the local perspective, the survey pointed to “quality production” as the most important factor, followed by “contract”, “top management engagement”, “risk management”, and “communication” as the most relevant factors for IT outsourcing success in the technological innovation hubs of Alagoas.
Brace-Free Rehabilitation after Isolated Anterior Cruciate Ligament Reconstruction with Hamstring Tendon Autograft Is Not Inferior to Brace-Based Rehabilitation—A Randomised Controlled Trial
Authors: Schoepp Christian , Ohmann Tobias , Martin Wolfgang , Praetorius Arthur , Seelmann Christine , Dudda Marcel , Stengel Dirk , Hax Jakob
Published: March 2023

Purpose: The postoperative use of a rehabilitative knee brace after isolated primary anterior cruciate ligament (ACL) reconstruction (ACLR) using a hamstring tendon (HT) autograft is controversial. A knee brace may provide subjective safety but can cause damage if applied incorrectly. The aim of this study is to evaluate the effect of a knee brace on clinical outcomes following isolated ACLR using HT autograft. Methods: In this prospective randomised trial, 114 adults (32.4 ± 11.5 years, 35.1% women) underwent isolated ACLR using HT autograft after primary ACL rupture. Patients were randomly assigned to wear either a knee brace (n = 58) or no brace (n = 56) for 6 weeks postoperatively. An initial examination was performed preoperatively, and at 6 weeks and 4, 6, and 12 months. The primary endpoint was the subjective International Knee Documentation Committee (IKDC) score to measure participants’ subjective perceptions. Secondary endpoints included objective knee function assessed by IKDC, instrumented knee laxity measurements, isokinetic strength tests of the knee extensors and flexors, Lysholm Knee Score, Tegner Activity Score, Anterior Cruciate Ligament—Return to Sport after Injury Score, and quality of life determined by Short Form-36 (SF36). Results: There were no statistically significant or clinically meaningful differences in IKDC scores between the two study groups (3.29, 95% confidence interval (CI) −1.39 to 7.97, p = 0.03 for evidence of non-inferiority of brace-free compared with brace-based rehabilitation). The difference in Lysholm score was 3.20 (95% CI −2.47 to 8.87); the difference in SF36 physical component score 0.09 (95% CI −1.93 to 3.03). In addition, isokinetic testing did not reveal any clinically relevant differences between the groups (n.s.). Conclusions: Brace-free rehabilitation is non-inferior to a brace-based protocol regarding physical recovery 1 year after isolated ACLR using HT autograft. Consequently, the use of a knee brace might be avoided after such a procedure. Level of Evidence: Level I, therapeutic study.
Perimount MAGNA Ease vs. INSPIRIS Resilia Valve: A PS-Matched Analysis of the Hemodynamic Performances in Patients below 70 Years of Age
Authors: Francica Alessandra , Tonelli Filippo , Rossetti Cecilia , Galeone Antonella , Perrone Fabiola , Luciani Giovanni , Onorati Francesco
Published: March 2023

Background: During the past decade, the Perimount Magna Ease (PME) bioprosthesis has been implanted worldwide for aortic valve replacement (AVR). Recently, the INSPIRIS Resilia (IR) valve has been introduced as the newest generation of pericardial bioprostheses. However, few data have been reported about patients ≤70 years, and no comparisons in terms of hemodynamic performance between these two bioprostheses have been ever reported. Methods: Patients aged <70 years undergoing AVR were considered for comparison between PME (n = 238) and IR (n = 192). Propensity score (PS) matching was performed by logistic regression with adjustment for eight key baseline variables. The two prostheses were compared in terms of hemodynamic performances up to 3 years postoperatively. Sub-analysis according to prosthetic size-category was accomplished. Results: A total of 122 pairs with similar baseline characteristics were obtained from the PS-matching. The two prostheses showed comparable hemodynamic performances at one year (Gmean: 11.3 ± 3.5 mmHg vs. 11.9 ± 5.4 mmHg; p = 0.8) and at 3 years postoperatively (Gmean: 12.2 ± 7.9 mmHg vs. 12.8 ± 5.2 mmHg for; p = 0.3). The sub-analysis of size-category confirmed no statistical differences concerning the hemodynamic performances for each annulus size. Conclusions: This first PS-matched analysis demonstrated that the newly developed IR valve achieves the same safety and efficacy of the PME valve during mid-term follow-up in patients aged <70 years.
Quality of Life after Transcatheter Aortic Valve Replacement in Sarcopenic Patients Using the Toronto Aortic Stenosis Quality of Life Questionnaire
Authors: Pesarini Gabriele , Ruzzarin Alessandro , Bonatti Matteo , Pescoller Felix , Engl Patrick , Oberhollenzer Rainer , Ribichini Flavio , Donazzan Luca
Published: March 2023

Background: Sarcopenia is the core component of frailty; however, its role in patients undergoing transcatheter aortic valve replacement (TAVR) is a matter of debate. The Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) is a validated instrument for assessing quality of life (QoL) in patients with severe aortic stenosis (AS). Aims: We aim to evaluate the QoL of sarcopenic and non-sarcopenic patients with severe AS undergoing TAVR. Methods: TASQ was prospectively administered to patients undergoing TAVR. All patients completed the TASQ before TAVR and at a 3-month follow-up. The study population was divided in two groups according to sarcopenic status. The primary endpoint was the TASQ score in the sarcopenic and non-sarcopenic cohorts. Results: In total, 99 patients were eligible for the analysis. In both sarcopenic (n = 56) and non-sarcopenic (n = 43) cohorts, significant changes were observed in the overall TASQ score and in all but one (i.e., health expectations) of the individual domains (p < 0.01). Sarcopenic and non-sarcopenic patients showed substantial improvements across TASQ subscores. The mean change in overall TASQ score at three months revealed a significant improvement in both cohorts (p < 0.01). Health expectations worsened in sarcopenic patients at the 3-month follow-up (p = 0.06). Conclusions: The TASQ questionnaire revealed changes in QoL after TAVR, regardless of patients’ sarcopenic status. Health status improved substantially in both sarcopenic and non-sarcopenic patients following TAVR. Lack of improvement in health expectations seems to depend on patients’ expectations regarding the procedure and specific aspects in the evaluation of the outcome.
Conduction Disorders after Surgical Aortic Valve Replacement Using a Rapid Deployment Aortic Valve Prosthesis: Medium-Term Follow-Up
Authors: Mogilansky Christian , Massoudy Parwis , Czesla Markus , Balan Robert
Published: March 2023

Background: We have previously reported that the incidence of postoperative conduction disorders, especially left bundle branch block (LBBB), after implantation of a rapid deployment Intuity™ Elite aortic valve prosthesis (Edwards Lifesciences, Irvine, CA, USA), was significantly increased compared with conventional aortic valve replacement. We were now interested in how these disorders behaved at intermediate follow-up. Methods: All 87 patients who had undergone surgical aortic valve replacement (SAVR) using the rapid deployment Intuity™ Elite prosthesis and were shown to have conduction disorders at the time of hospital discharge were followed up after surgery. These patients’ ECGs were recorded at least 1 year after surgery, and the persistence of the new postoperative conduction disorders was assessed. Results: At hospital discharge, 48.1% of the patients had developed new postoperative conduction disorders, with LBBB being the predominant conduction disturbance (36.5%). At medium-term follow-up (526 days, standard deviation (SD) = 169.6, standard error (SE) = 19.3 days, respectively), 44% of the new LBBB and 50% of the new right bundle branch block (RBBB) had disappeared. There was no new atrio-ventricular block III (AVB III) that occurred. One new pacemaker (PM) was implanted during follow-up because of AVB II Mobitz type II. Conclusions: At medium-term follow-up after the implantation of a rapid deployment Intuity™ Elite aortic valve prosthesis, the number of new postoperative conduction disorders, especially LBBB, has considerably decreased but remains high. The incidence of postoperative AV block III remained stable.
Low- vs. High-Power Laser for Holmium Laser Enucleation of Prostate
Authors: Gkolezakis Vasileios , Somani Bhaskar , Tokas Theodoros
Published: March 2023

Holmium laser enucleation of the prostate (HoLEP) constitutes an established technique for treating patients with symptomatic bladder outlet obstruction. Most surgeons perform surgeries using high-power (HP) settings. Nevertheless, HP laser machines are costly, require high-power sockets, and may be linked with increased postoperative dysuria. Low-power (LP) lasers could overcome these drawbacks without compromising postoperative outcomes. Nevertheless, there is a paucity of data regarding LP laser settings during HoLEP, as most endourologists are hesitant to apply them in their clinical practice. We aimed to provide an up-to-date narrative looking at the impact of LP settings in HoLEP and comparing LP with HP HoLEP. According to current evidence, intra- and post-operative outcomes as well as complication rates are independent of the laser power level. LP HoLEP is feasible, safe, and effective and may improve postoperative irritative and storage symptoms.
Observations of Multiple Young-of-the-Year to Juvenile White Sharks (Carcharodon carcharias) within South-West Australian Waters and Its Implications for a Potential Nursery Area(s)
Authors: O’Connell Craig P. , Payne Marc , Payne Shelley , Eller Luke J. , Shaw Jon , McGregor Andrew , Rerekura Andre , Stewart Madison , Fox Andrew
Published: March 2023

The white shark (Carcharodon carcharias) is a globally distributed top predator. Due to its ecological importance, increasing knowledge through continued research can enhance management measures. One such facet of biological knowledge is the identification of shark nursery areas, as protection of these regions is critical to species survival. Presently, there are two known C. carcharias nursery areas in association with the Eastern Australian subpopulation; however, a nursery area associated with the Southern-Western Australian C. carcharias subpopulation has yet to be identified. Herein, we report opportunistic laser photogrammetry, stereo-photogrammetry, and baited remote underwater video systems (BRUVS) data that resulted in the identification of sixteen young-of-the-year (YOY)-juvenile C. carcharias from two separate regions (i.e., Salisbury Island and Daw Island) in South-West Australia. Additionally, anecdotal bycatch data associated with two YOY C. carcharias (i.e., 1.40 and 1.70 m total length) from another location within the Great Australian Bight are reported. While it is premature to conclude that these sites represent discrete or an expansive interconnected nursery area, the sightings success in this study is indicative that future research may want to consider implementing a study during a similar time period (i.e., February–March) while using a similar attractant methodology (i.e., bottom-set BRUVS baited with squid [Sepioteuthis australis]) to help elucidate the unique life-history characteristics of this C. carcharias subpopulation.
Numerical Study on the Effects of the Multiple Porous Medium Breakwaters on the Propagation of the Solitary Wave
Authors: Zhu Kui , Jiang Runxiang , Sun Zhaolong , Qin Hao , Cheng Zeqi , Wang Yang , Zhao Enjin
Published: March 2023

Submerged breakwater, as an important marine engineering structure, can effectively absorb wave energy and is widely used in marine engineering protection. As a new type of breakwater, porous medium breakwater has a certain influence on wave propagation. However, the influence of multiple porous medium submerged breakwaters on extreme waves remains to be studied. In the study, considering effects of extreme waves generated by hurricanes or tsunamis, the influence of the solitary wave on the multiple semi-circle porous medium breakwater is systematically investigated. According to the computational fluid dynamics theory, a numerical tank is established, in which the porous medium module is coupled. The computational capability of this model is verified first. Then, depending on the model, a series of cases are carried out to study the effects of different porous medium breakwaters on the propagation of the solitary wave. The results show that when the porosity is 0.8, the force on the submerged breakwaters is the smallest, and the water level and the velocity decrease seriously. With the increase in the diameter of the submerged breakwater, the wave profile gradually becomes flat. The higher the wave height, the more serious the wave deformation after passing through the submerged breakwater.
The Growth and Conidiation of Purpureocillium lavendulum Are Co-Regulated by Nitrogen Sources and Histone H3K14 Acetylation
Authors: Tang Ping , Han Jing-Jing , Zhang Chen-Chen , Tang Ping-Ping , Qi Feng-Na , Zhang Ke-Qin , Liang Lian-Ming
Published: March 2023

Plant-parasitic nematodes cause severe economic losses to agriculture. As important biocontrol agents, nematophagous fungi evolved the ability to obtain nitrogen sources from nematodes. However, the impact of nitrogen sources on the growth and development of these fungi is largely unknown. In this study, we aimed to better understand how nitrogen sources could influence vegetative growth and conidiation through epigenetic regulation in the nematophagous fungus, Purpureocillium lavendulum. Through nutrition screening, we found a phenomenon of the fungus, limited colony extension with a large amount of conidia production when cultured on PDA media, can be altered by adding ammonia nitrate. Characterized by site-directed mutagenesis, the histone H3K14 acetylation was found to be involved in the alternation. Furthermore, the acetyltransferase PlGCN5 was responsible for H3K14 acetylation. Knockout of Plgcn5 severely diminished conidiation in P. lavendulum. Chip-seq showed that H3K14ac distributed in conidiation regulating genes, and genes in the MAPK pathway which may be the downstream targets in the regulation. These findings suggest that histone modification and nitrogen sources coordinated lifestyle regulation in P. lavendulum, providing new insight into the mechanism of growth regulation by nutritional signals for the carnivorous fungus.
Effectiveness of Radiomic ZOT Features in the Automated Discrimination of Oncocytoma from Clear Cell Renal Cancer
Authors: Carlini Gianluca , Gaudiano Caterina , Golfieri Rita , Curti Nico , Biondi Riccardo , Bianchi Lorenzo , Schiavina Riccardo , Giunchi Francesca , Faggioni Lorenzo , Giampieri Enrico , Merlotti Alessandra , Dall’Olio Daniele , Sala Claudia , Pandolfi Sara , Remondini Daniel , Rustici Arianna , Pastore Luigi Vincenzo , Scarpetti Leonardo , Bortolani Barbara , Cercenelli Laura , Brunocilla Eugenio , Marcelli Emanuela , Coppola Francesca , Castellani Gastone
Published: March 2023

Background: Benign renal tumors, such as renal oncocytoma (RO), can be erroneously diagnosed as malignant renal cell carcinomas (RCC), because of their similar imaging features. Computer-aided systems leveraging radiomic features can be used to better discriminate benign renal tumors from the malignant ones. The purpose of this work was to build a machine learning model to distinguish RO from clear cell RCC (ccRCC). Method: We collected CT images of 77 patients, with 30 cases of RO (39%) and 47 cases of ccRCC (61%). Radiomic features were extracted both from the tumor volumes identified by the clinicians and from the tumor’s zone of transition (ZOT). We used a genetic algorithm to perform feature selection, identifying the most descriptive set of features for the tumor classification. We built a decision tree classifier to distinguish between ROs and ccRCCs. We proposed two versions of the pipeline: in the first one, the feature selection was performed before the splitting of the data, while in the second one, the feature selection was performed after, i.e., on the training data only. We evaluated the efficiency of the two pipelines in cancer classification. Results: The ZOT features were found to be the most predictive by the genetic algorithm. The pipeline with the feature selection performed on the whole dataset obtained an average ROC AUC score of 0.87 ± 0.09. The second pipeline, in which the feature selection was performed on the training data only, obtained an average ROC AUC score of 0.62 ± 0.17. Conclusions: The obtained results confirm the efficiency of ZOT radiomic features in capturing the renal tumor characteristics. We showed that there is a significant difference in the performances of the two proposed pipelines, highlighting how some already published radiomic analyses could be too optimistic about the real generalization capabilities of the models.