bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical trials for treating recurrent head and neck cancer with boron neutron capture therapy using the Tsing‐Hua Open Pool Reactor
Authors: Wang Ling‐Wei , Liu Yen‐Wan Hsueh , Chou Fong‐In , Jiang Shiang‐Huei
Published: June 2018

Head and neck (HN) cancer is an endemic disease in Taiwan, China. Locally recurrent HN cancer after full‐dose irradiation poses a therapeutic challenge, and boron neutron capture therapy (BNCT) may be a solution that could provide durable local control with tolerable toxicity. The Tsing‐Hua Open Pool Reactor (THOR) at National Tsing‐Hua University in Hsin‐Chu, provides a high‐quality epithermal neutron source for basic and clinical BNCT research. Our first clinical trial, entitled “A phase I/II trial of boron neutron capture therapy for recurrent head and neck cancer at THOR”, was carried out between 2010 and 2013. A total of 17 patients with 23 recurrent HN tumors who had received high‐dose photon irradiation were enrolled in the study. The fructose complex of l‐boronophenylalanine was used as a boron carrier, and a two‐fraction BNCT treatment regimen at 28‐day intervals was used for each patient. Toxicity was acceptable, and although the response rate was high (12/17), re‐recurrence within or near the radiation site was common. To obtain better local control, another clinical trial entitled “A phase I/II trial of boron neutron capture therapy combined with image‐guided intensity‐modulated radiotherapy (IG‐IMRT) for locally recurrent HN cancer” was initiated in 2014. The first administration of BNCT was performed according to our previous protocol, and IG‐IMRT was initiated 28 days after BNCT. As of May 2017, seven patients have been treated with this combination. The treatment‐related toxicity was similar to that previously observed with two BNCT applications. Three patients had a complete response, but locoregional recurrence was the major cause of failure despite initially good responses. Future clinical trials combining BNCT with other local or systemic treatments will be carried out for recurrent HN cancer patients at THOR.
Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich's ataxia
Authors: Palandri Amandine , Martin Elodie , Russi Maria , Rera Michael , Tricoire Hervé , Monnier Véronique
Published: June 2018

Friedreich's ataxia (FA) is caused by reduced levels of frataxin, a highly conserved mitochondrial protein. There is currently no effective treatment for this disease, which is characterized by progressive neurodegeneration and cardiomyopathy, the latter being the most common cause of death in patients. We previously developed a Drosophila melanogaster cardiac model of FA, in which the fly frataxin is inactivated specifically in the heart, leading to heart dilatation and impaired systolic function. Methylene Blue (MB) was highly efficient to prevent these cardiac dysfunctions. Here, we used this model to screen in vivo the Prestwick Chemical Library, comprising 1280 compounds. Eleven drugs significantly reduced the cardiac dilatation, some of which may possibly lead to therapeutic applications in the future. The one with the strongest protective effects was paclitaxel, a microtubule-stabilizing drug. In parallel, we characterized the histological defects induced by frataxin deficiency in cardiomyocytes and observed strong sarcomere alterations with loss of striation of actin fibers, along with full disruption of the microtubule network. Paclitaxel and MB both improved these structural defects. Therefore, we propose that frataxin inactivation induces cardiac dysfunction through impaired sarcomere assembly or renewal due to microtubule destabilization, without excluding additional mechanisms. This study is the first drug screening of this extent performed in vivo on a Drosophila model of cardiac disease. Thus, it also brings the proof of concept that cardiac functional imaging in adult Drosophila flies is usable for medium-scale in vivo pharmacological screening, with potent identification of cardioprotective drugs in various contexts of cardiac diseases.
Recapitulating muscle disease phenotypes with myotonic dystrophy 1 induced pluripotent stem cells: a tool for disease modeling and drug discovery
Authors: Mondragon-Gonzalez Ricardo , Perlingeiro Rita C. R.
Published: June 2018

Myotonic dystrophy 1 (DM1) is a multisystem disorder primarily affecting the central nervous system, heart and skeletal muscle. It is caused by an expansion of the CTG trinucleotide repeats in the 3′ untranslated region of the DMPK gene. Although patient myoblasts have been used for studying the disease in vitro, the invasiveness as well as the low accessibility to muscle biopsies motivate the development of alternative reliable myogenic models. Here, we established two DM1 induced pluripotent stem (iPS) cell lines from patient-derived fibroblasts and, using the PAX7 conditional expression system, differentiated these into myogenic progenitors and, subsequently, terminally differentiated myotubes. Both DM1 myogenic progenitors and myotubes were found to express the intranuclear RNA foci exhibiting sequestration of MBNL1. Moreover, we found the DM1-related mis-splicing, namely BIN1 exon 11 in DM1 myotubes. We used this model to test a specific therapy, antisense oligonucleotide treatment, and found that this efficiently abolished RNA foci and rescued BIN1 mis-splicing in DM1 iPS cell-derived myotubes. Together, our results demonstrate that myotubes derived from DM1 iPS cells recapitulate the critical molecular features of DM1 and are sensitive to antisense oligonucleotide treatment, confirming that these cells can be used for in vitro disease modeling and candidate drug testing or screening.

This article has an associated First Person interview with the first author of the paper.
The effect of gap junction-mediated transfer of miR-200b on osteogenesis and angiogenesis in a co-culture of MSCs and HUVECs
Authors: Fan Xiaoting , Teng Yi , Ye Zhaoyang , Zhou Yan , Tan Wen-Song
Published: June 2018

For successful engineering of pre-vascularized bone tissue in vitro, understanding the interactions between vasculogenic cells and bone-forming cells is a prerequisite. Mounting evidence indicates that microRNAs can serve as intercellular signals that allow cell–cell communication. Here, the role of the transfer of the microRNA miR-200b between vasculogenic and osteogenic cells was explored in a co-culture system. Rat bone-marrow derived mesenchymal stem cells (BMSCs) formed functional gap junctions composed of connexin 43 (Cx43, also known as GJA1) with human umbilical vein endothelial cells (HUVECs), through which miR-200b could transfer from BMSCs to HUVECs to regulate osteogenesis and angiogenesis. As a negative regulator, the decrease in miR-200b level in BMSCs derepressed the expression of VEGF-A, leading to increased osteogenic differentiation. Once inside HUVECs, miR-200b reduced the angiogenic potential of HUVECs through downregulation of ZEB2, ETS1, KDR and GATA2. Additionally, TGF-β was found to trigger the transfer of miR-200b to HUVECs. Upon adding the TGF-β inhibitor SB431542 or TGF-β-neutralizing antibody, the formation of capillary-like structures in co-culture could be partially rescued. These findings may be fundamental to the development of a cell-based bone regeneration strategy.
Development of a national core dataset for the Iranian ICU patients outcome prediction: a comprehensive approach
Authors: Atashi Alireza , Ahmadian Leila , Rahmatinezhad Zahra , Miri Mirmohammad , Nazeri Najmeh , Eslami Saeid
Published: June 2018

Objective

To define a core dataset for intensive care unit (ICU) patients outcome prediction in Iran. This core data set will lead us to design ICU outcome prediction models with the most effective parameters.

Methods

A combination of literature review, national survey and expert consensus meetings were used. First, a literature review was performed by a general search in PubMed to find the most appropriate models for intensive care mortality prediction and their parameters. Second, in a national survey, experts from a couple of medical centres in all parts of Iran were asked to comment on a list of items retrieved from the earlier literature review study. In the next step, a multi-disciplinary committee of experts was installed. In four meetings, each data item was examined separately and included/excluded by committee consensus.

Results

The combination of the literature review findings and experts’ consensus resulted in a draft dataset including 26 data items. Ninety-two percent of data items in the draft dataset were retrieved from the literature study and the others were suggested by the experts. The final dataset of 24 data items covers patient history and physical examination, chemistry, vital signs, oxygenations and some more specific parameters.

Conclusions

This dataset was designed to develop a nationwide prognostic model for predicting ICU mortality and length of stay. This dataset opens the door for creating standardised approaches in data collection in the Iranian intensive care unit estimation of resource utility.
A pesquisa em trade-offs de custos logísticos: estudo bibliométrico no período de 2006 a 2016
Authors: Barbosa Luciano Wallace Gonçalves , Gamarano Clárison Gonçalves , Pereira Ana Luiza Cordeiro , Policarpo Renata Veloso Santos , Mapa Sílvia Maria Santana
Published: June 2018

A otimização dos custos e o acréscimo de benefícios contraídos pelo processo logístico se dão a partir da identificação e da exploração dos trade-offs de custos logísticos. Nesse sentido, o presente trabalho se propõe a apresentar, por meio da metodologia de estudo bibliométrico, a evolução e as principais práticas utilizadas na gestão destes custos nas organizações por meio da avaliação de trade-offs em processos logísticos. Para o estudo, foram levantados sessenta e quatro artigos científicos publicados no período de 2006 a 2016 em periódicos classificados pelo Qualis 2014 e ranqueados entre A1 e B2, disponibilizados na Plataforma Sucupira. Os artigos coletados foram pesquisados nas áreas de Engenharias III, da qual a Engenharia de Produção faz parte, e nas Ciências Sociais Aplicadas, onde o tema custos logísticos também é amplamente abordado. A pesquisa realizou-se em três etapas: coleta de dados, análise e síntese. Os resultados revelaram que a área de Pesquisa Operacional lidera como ciência empregada ao utilizar métodos descritivos e estocásticos. Enquanto aspecto restritivo, ficou evidente a dificuldade em aplicações diretas em trade-offs de custos logísticos, o que caracteriza uma lacuna de estudos no que diz respeito à integração entre a logística e a contabilidade.
Mapa de fluxo de valor estendido a avaliação do desempenho energético em consumidores industriais: um estudo de caso brasileiro
Authors: Hedlund Fabrício Nicoletti , Forcellini Fernando Antônio
Published: June 2018

O setor industrial consome a maior parcela da energia demandada no Brasil e no mundo, em particular a eletricidade, e melhorias na sua performance energética proporcionam benefícios ambientais e econômicos a todas as partes envolvidas na cadeia de suprimentos. Uma forma de avaliação do desempenho energético é por meio da extensão da ferramenta Mapa do Fluxo de Valor, do Lean Manufacturing, incorporando outros insumos. Entretanto, não há convergência para um modelo em comum, carece de informações operacionais sobre a modelagem energética das operações e falta uma análise dos desperdícios no impacto global da organização. A partir disso, é proposta uma extensão do MFV para viabilizar a avaliação do desempenho de insumos energéticos de uma organização industrial. Devido ao setor elétrico ter impacto tanto em questões ambientais como econômicas, suas regras de fornecimento são utilizadas como referência. O estudo apresenta um estudo de caso no qual foram identificados desperdícios com o método proposto e resultados positivos obtidos.
Epithelial–Mesenchymal Transition Induced by SMAD4 Activation in Invasive Growth Hormone-Secreting Adenomas
Authors: Shan Xiaosong , Liu Qian , Li Zhenye , Li Chuzhong , Gao Hua , Zhang Yazhuo
Published: June 2018

Background

The detection and treatment of invasive growth hormone-secreting pituitary adenoma (GHPA) remains challenging. Several transcription factors promoting the epithelial–mesenchymal transition (EMT) can act as cofactors for the transforming growth factor-beta (TGF-ß)/SMAD4. The goal of this study was to investigate the association of SMAD4 expression and clinicopathologic features using a tissue microarray analysis (TMA). The levels of SMAD4 and the related genes of EMT in GHPAs were analyzed by q-PCR and western blot. SMAD4 was strongly expressed in 15/19 cases (78.9%) of invasive GHPA and 10/42 cases (23.8%) of noninvasive GHPA (χ2=10.887,p=0.000). In the high SMAD4 group, a headache was reported in 16/25 cases (64%) compared with 13/36 cases (36.1%) in the low SMAD4 group (χ2=4.565,p=0.032). The progression-free survival (PFS) in the high group was lower than that in the low group (p=0.026). qRT-PCR and western blot analysis further revealed a significant downregulation of E-cadherin and upregulation of N-cadherin and vimentin in the invasive GHPA group. SMAD4 was associated with increased levels of invasion of GH3 cells, as determined by a transwell test. SMAD4 downregulated E-cadherin levels and increased the levels of N-cadherin and vimentin. Our data provide evidence that SMAD4 is a potential prognosis biomarker and a therapeutic target for patients with invasive GHPA.
A brief review on the erosion-corrosion behavior of engineering materials
Authors: Kuruvila Roshan , Thirumalai Kumaran S. , Khan M. Adam , Uthayakumar M.
Published: June 2018

The efficiency of industry depends upon the working conditions of the equipment and components used in the industrial process. The biggest problems faced by the industries are the problems of erosion and corrosion. The harmful effects of corrosion will lead to material loss, which results from the degradation of the equipment. The degradation of the equipment will cause the breakdown of the plant; moreover, it is a threat to the safety of people, and also from the point of conservation, it can cause the exploitation of available resources. The cost of replacing equipment increases the expense, and it can also result in the temporary shutdown of the plant. The protection of surfaces from the adverse effects of corrosion and erosion-corrosion is a matter of great concern in most industrial applications. Advancements in technology provides a wide range of techniques to overcome adverse conditions. The selection of appropriate technology must be from the viewpoint of their interaction with the environment. This review paper addresses the adverse effects of erosion-corrosion in the present scenario.
Basic positively closed classes in three-valued logic
Authors: Marchenkov Sergey S. , Chernyshev Anatoliy V.
Published: June 2018

Basic positively closed classes are intersections of positively precomplete classes. We prove that three-valued logic contains exactly 79 basic positively closed classes. Each class is described in terms of endomorphism semigroups.
Spectroscopic characterization of the Co-substituted C-terminal domain of rubredoxin-2
Authors: Galle Lisa M. , Cutsail III George E. , Nischwitz Volker , DeBeer Serena , Span Ingrid
Published: June 2018

Pseudomonas putida rubredoxin-2 (Rxn2) is an essential member of the alkane hydroxylation pathway and transfers electrons from a reductase to the membrane-bound hydroxylase. The regioselective hydroxylation of linear alkanes is a challenging chemical transformation of great interest for the chemical industry. Herein, we report the preparation and spectroscopic characterization of cobalt-substituted P. putida Rxn2 and a truncated version of the protein consisting of the C-terminal domain of the protein. Our spectroscopic data on the Co-substituted C-terminal domain supports a high-spin Co(II) with a distorted tetrahedral coordination environment. Investigation of the two-domain protein Rxn2 provides insights into the metal-binding properties of the N-terminal domain, the role of which is not well understood so far. Circular dichroism, electron paramagnetic resonance and X-ray absorption spectroscopies support an alternative Co-binding site within the N-terminal domain, which appears to not be relevant in nature. We have shown that chemical reconstitution in the presence of Co leads to incorporation of Co(II) into the active site of the C-terminal domain, but not the N-terminal domain of Rxn2 indicating distinct roles for the two rubredoxin domains.
Comparison of Core Muscle Activation Between a Prone Bridge and 6-RM Back Squats
Authors: van den Tillaar Roland , Saeterbakken Atle Hole
Published: June 2018

The purpose of this study was to compare core muscle activation during a prone bridge (plank) until failure and 6-RM back squats. Twelve resistance-trained males (age 23.5 ± 2.6 years, body mass 87.8 ± 21.3 kg, body height 1.81 ± 0.08 m) participated in this study. Total exercise time and EMG activity of the rectus abdominis, external abdominal oblique and erector spinae were measured during 6-RM back squats and a prone bridge with a weight of 20% of participants’ body mass on their lower back. The main findings showed non-significant differences between the exercises in the rectus abdominis or external oblique, but greater erector spinae activation in squatting. Furthermore, in contrast to the prone bridge, the erector spinae and rectus abdominis demonstrated increasing muscle activation throughout the repetitions while squatting, whereas the prone bride demonstrated increasing external oblique activation between the beginning and the middle of the set. It was concluded that since squatting resulted in greater erector spine activation, but similar rectus abdominis and oblique external activation as the prone bridge, high-intensity squats rather than isometric low intensity core exercises for athletes would be recommended.
Interactions BetweenCOL5A1Gene and Risk of the Anterior Cruciate Ligament Rupture
Authors: Lulińska-Kuklik Ewelina , Rahim Masouda , Domańska-Senderowska Daria , Ficek Krzysztof , Michałowska-Sawczyn Monika , Moska Waldemar , Kaczmarczyk Mariusz , Brzeziański Michał , Brzeziańska-Lasota Ewa , Cięszczyk Paweł , September Alison V.
Published: June 2018

Collagen alpha-1(V) chain, encoded by the COL5A1 gene, plays a crucial role in abundant fibrillar collagens supporting many tissues in the body containing type I collagen and appears to regulate the association between heterotypic fibers composed of both type I and type V collagen occurring among others in muscles, tendons and ligaments. Taking this fact into consideration we decided to examine the association between COL5A1 rs12722 and rs13946 polymorphisms, individually and as inferred haplotypes, with anterior cruciate ligament rupture risk (ACLR) in professional soccer players. A total of 134 male professional soccer players with surgically diagnosed primary anterior cruciate ligament ruptures and 211 apparently healthy male professional soccer players, who were without any self-reported history of ligament or tendon injury, were included in the study. Both the cases and the healthy controls were recruited from the same soccer teams, of a similar age category, and had a comparable level of exposure to anterior cruciate ligament injury. Genomic DNA was extracted from oral epithelial cells using GenElute Mammalian Genomic DNA MiniprepKit. All samples were genotyped for the rs12722 and rs13946 polymorphisms using a Rotor-Gene realtime polymerase chain reaction. Statistically significant differences in the genotype frequencies for the COL5A1 rs13946 polymorphisms in dominant modes of inheritance occurred (p = 0.039). Statistically significant differences were documented only in the dominant model under the representation tendency of the C-C haplotype in the ACLR group compared to controls (p = 0.038). Our results suggest that variation in the COL5A1 gene may be one of the non-modifiable factors associated with the ACL injury in professional soccer players. The C-C rs12722-rs13946 haplotype provides a protective effect against the ACL tear.
Effect of plantation clearcutting on carnivore presence in industrial forest landscapes in south-central Chile
Authors: Escudero-Páez Sandra P. , Botero-Delgadillo Esteban , Estades Cristián F.
Published: June 2018

Information on how wildlife is affected by pine plantation clearcutting is relevant for designing management strategies to promote biodiversity conservation in productive systems. By comparing the number of records of carnivores in a mosaic of pine plantations and native forest remnants before and after pine harvesting, we assessed the effect of plantation clearcutting on carnivore presence in ten sampling areas in Central Chile. We also included a number of covariates to account for their potential confounding effects, for example, the distance between each site and the nearesting human settlement and vegetation cover. A total of 10 species were observed, but no negative effect of clearcutting on carnivore presence was detected. Only the culpeo fox (Lycalopex culpaeus) responded positively to the harvesting of pine plantations. The threatened kodkod (Leopardus guigna) was absent in clearcut areas and the number of records increased in forests or plantations with a dense understorey. The domestic dog (Canis lupus familiaris) responded positively to human settlements and seems to prefer more open areas. The number of records for the Puma (Puma concolor) and the domestic cat (Felis silvestris catus) was too few, and hence, we could not make any inference regarding these two species. The other species recorded showed different responses to one or more of the included covariates. Although our results showed that the recording of some species could change in the short term after pine harvesting, future studies should assess the impact of clearcutting at a much higher scale, both in terms of space and time.
A Simple Method to Estimate Numerically the Residual Stresses in Bodies Subjected to Cyclic Loads
Authors: Pazdanowski Michał
Published: June 2018

Residual stresses in metallic materials may arise during the manufacturing process as a byproduct of the process itself, or they may be introduced on purpose to enhance the behavior of the product in service (for instance the compressive hoop stress in railroad vehicle wheels). Depending on the service regimen, the residual stresses in a body subjected to cyclic loads may either attain the stable (time-independent) state, thus leading to elasto-plastic shakedown of the body to the given loading program, or may not stabilize, resulting in the destruction of the body because of the ratcheting (alternating plasticity). The residual stresses in a considered body may be calculated using the standard incremental approach, where the final state is found through following step by step the actual loading program, or they may be estimated by the application of plastic shakedown theorems. The first approach, although yielding precise information on body behavior, may be extremely time consuming in the case of cyclic loads. The second approach, although yielding only an estimate of the final residual stress distributions, is much more time efficient. The numerical approach discussed in this article is based on Melan’s theorem and allows for a reasonably accurate estimate of residual stresses induced in an elastic plastic body made of strain hardening material as long as an upper bound of the loading program is known. The tests performed on an autofrettage problem exhibit excellent agreement with an exact analytical solution. The results for the calculations of the residual stresses in railroad rails subjected to simulated service loads are provided.
Residual Stress in Self-Piercing Riveting (SPR) Joints—A Review
Authors: Haque Rezwanul
Published: June 2018

Self-piercing riveting (SPR) is a high-speed method of joining sheet materials by creating a mechanical interlock between the sheets. Unlike conventional riveting, SPR does not require predrilling. Automobile industries adopted this joining technique because of its suitability in joining dissimilar materials and doing so at high-volume production. However, in SPR, the rivet plastically deforms and residual stress develops in the joint. The deformation behavior of the rivet and the residual stress distribution in SPR joints are poorly understood. This leads to difficulties in developing new product and optimizing the process. Development of new rivet and die geometries are also limited since the residual stress state in SPR joints are not fully described. Several key issues in modeling and measuring residual stress in SPR joints are discussed. How the plastically induced residual stress can be linked to the different phases of the riveting process is also described. This is an area of SPR with numerous prospects for research. It is expected that advancement will be achieved by a combination of techniques, including laboratory recreation, finite element modeling and manufacturing trials.
In Situ Investigations of Elastic Strain State in Deep Rolled 4140H Steel by Neutron Diffraction Method
Authors: Meyer Heiner , Epp Jérémy , Pirling Thilo , Zoch Hans-Werner
Published: June 2018

A deep rolling process was applied on 4140H steel specimens with a self-built loading frame and investigated in situ with neutron radiation using the SALSA instrument at the Institut Laue-Langevin (ILL). A neutron diffraction stress imaging approach was developed and used to determine material changes from the surface up to several millimeters inside the material by single expositions. The strains could be evaluated as deviations of the diffraction signal along the height of an area detector, and the theoretical maximum depth resolution was given by geometrical magnification together with the detector pixel size. The results of these experiments together with complementary post-process investigations could be used to link the internal load during the process with resulting material modifications such as the generated residual strains.
Residual Stress in Expanded Austenite on Stainless Steel; Origin, Measurement, and Prediction
Authors: Somers Marcel A. J. , Kücükyildiz Ömer C. , Ormstrup Casper A. , Alimadadi Hossein , Hattel Jesper H. , Christiansen Thomas L. , Winther Grethe
Published: June 2018

Expanded austenite is a supersaturated solid solution of nitrogen/carbon in austenite that forms as a case by the diffusion of nitrogen/carbon into austenitic stainless steel. Expanded austenite has a high level of hardness that provides resistance against galling and wear, superior resistance against localized corrosion, and contributes to improvement of the fatigue performance. This latter characteristic is a consequence of the huge compressive residual stresses in the expanded austenite case. Such stresses are induced by the high interstitial content in the austenite lattice and are accommodated elasto-plastically. The experimental assessment of the elastic lattice strains is complicated by the presence of steep composition-depth and stress-depth profiles, which necessitate special measurement or correction procedures to unravel the influence of composition and stress on the lattice spacing and avoid artifacts arising from (steep) lattice-spacing gradients. In the present work the sin2ψ method was combined with grazing incidence X-ray diffraction to keep the information depth during measurement shallow, independent of the (effective) tilt angle ψ. The plastic strains in the expanded austenite 27 zone were estimated from the lattice rotations, as determined with electron backscatter diffraction. It is demonstrated that the level of elastic lattice strains in expanded austenite can be adjusted by retracting part of the dissolved nitrogen. The experimental results for elastic and plastic strains are compared to those predicted by a comprehensive numerical model that simulates the time-dependent development of composition-depth and stress-depth profiles in expanded austenite. The work described in this manuscript is a combination of a review of previously achieved and published results as well as the newest results of ongoing research activities.
The sheep look forward: Counterfactuals, dystopias, and ecological science fiction as a social science enterprise
Authors: O’Neill Kate
Published: June 2018

John Brunner’s 1972 novel, The Sheep Look Up, is the story of the year leading up to a global ecological and political catastrophe. Set primarily in the United States in an unspecified near future, The Sheep Look Up tells the story of “death by a thousand cuts”: problem upon problem, malfeasance upon malfeasance, which accumulate, reinforce each other and are met only by a failing political and economic system that ultimately collapses under its own weight. This article reflects on themes and topics of the novel that resonate for social science theorists and teachers in the environmental social sciences, including global environmental politics. First, it provides a type of counterfactual analysis. It opens a window into how the world might have been had certain actions not been taken. Second, it provides a warning: how the world might be if we do not act. Third, it provides a model of how a disastrous transition might unfold as social resilience has been worn down. Looking back on the almost fifty years since the novel was written demonstrates how its scenario was averted through concerted government and societal actions, but the article also points out how Brunner’s work has strong resonance with our present – and at different times in the recent past.
El cristiano errante, de Antonio de Irisarri, y la literatura satírica en Centroamérica (El cristiano errante, by Antonio de Irisarri, and Satirical Literature in Central America)
Authors: Villafuerte Guzmán Félix Javier
Published: June 2018

Se analiza la novela El cristiano errante de Antonio de Irisarri, considerando su momento histórico, para mostrar los procesos de formación de estados nacionales en Centroamérica y su repercusión en las letras del Istmo. Esta obra constituye un ejemplo de literatura satírica, a la que se acudió como contramedida de parte de los sectores sociales conservadores, ante las medidas sociopolíticas que las corrientes políticas liberales trataron de implantar en las primeras etapas posteriores a la independencia. Abstract A study is provided of the novel El cristiano errante, by Antonio de Irisarri, within its historical context to elucidate the processes of the formation of nation states in Central America and their repercussions on its literature. This novel is an example of satirical literature developed by conservative social sectors as a countermeasure, in the face of the sociopolitical measures that liberal political currents tried to establish in the first stages after independence.
Ambidexter symmetricus Manning & Chace, 1971 (Decapoda, Processidae): first record for Rio Grande do Norte and overview of the species distribution on the Brazilian coast
Authors: Barbosa de Moraes Alex , Cosme Soares de Moraes Daniele , Felix Caetano França Nielson , Medeiros Malheiros Jéssica , Aurélio de Morais Freire Fúlvio
Published: June 2018

We present the first record of Ambidexter symmetricus Manning & Chace, 1971 for the state of Rio Grande do Norte, northeastern Brazil, filling a distribution gap of this species in the country. We confirm the preference of this species for seagrass meadows in the Curimataú river estuary. Lastly, a brief overview and an updated distribution map for the records of this species on the Brazilian coast are provided.
Tefsir Kitaplarındaki İsrailiyata Dair
Authors: ÇELEM Sema , ARAS Zakir
Published: June 2018

Muhammed İzzet Derveze (1888-1984) Filistin direniş hareketi içinde aktif rol alan Arap fikir ve siyaset adamı, müfessir ve tarihçidir. Bu yazı, Merhum Muhammed İzzet Derveze’nin El-Vaʿyu’l-İslāmī
dergisinde yayınlanan “Ḥavle’l-İsrāiliyyāt fī Kutubu’t-Tefsīr” adlı
makalesinin tercümesidir. 1966 yılında yayınlanan makalede yazar, tefsir kitaplarında var olan akıldışı rivayetleri değerlendirmekte ve bu haberlerin Kur'an'ın asıl mesajını örttüğünü düşündüğü için eleştirmektedir.
Gamma-diversity partitioning of gobiid fishes (Teleostei: Gobiidae) ensemble along of Eastern Tropical Pacific: biological inventory, latitudinal variation and species turnover v1
Authors: Valencia Omar
Published: June 2018

PCO plot based on gobies fish incidence data. All marine ecoregions and provinces were grouped sensu Spalding et al. (2007). Jaccard similarity was used as a resemblance measure of species composition.
Gamma-diversity partitioning of gobiid fishes (Teleostei: Gobiidae) ensemble along of Eastern Tropical Pacific: biological inventory, latitudinal variation and species turnover v1
Authors: Valencia Omar
Published: June 2018

Results of the additive and multiplicative diversity partitioning of gobiid fishes.
Sharing Success: A Review of Strategic Planning, Annual Reports, and Publicly Available Information from Academic Libraries
Authors: Springmier Kaitlin , Edwards Elizabeth , Bass Michelle B
Published: June 2018

Objective – This paper reports on a study which explored web-based information sharing practices in North American academic libraries. This study specifically focused on how selected academic libraries use data, reports, and other strategic planning documents to communicate success and demonstrate impact to stakeholders, administrators, and peers.
 
Methods – An environmental scan was conducted to explore the assessment programs and communication practices of 97 North American academic libraries. The population for this study was identified on the basis of several metrics: consortial membership, Association of Research Libraries (ARL) ranking on various criteria, and institutional attendance at the 2014 and 2016 Library Assessment Conferences (LAC). Researchers conducted content analyses on the websites of the 97 libraries to identify measures of institutional support for assessment and to explore the range, depth, and quality of data made available. These iterative analyses were supported by the use of a rubric developed based on emergent criteria observed during multiple phases of review.
 
Results – Of the libraries reviewed, 57% made some form of data available to the public. The most robust and effective use of data observed in this study involved the use of data to tell stories about the library and its impact. While this study found a positive correlation between libraries with clear investments in assessment and their use of data in public documents, it found that other factors such as an institution’s consortial memberships or funding model may more strongly influence a library’s decision to make data available.
 
Conclusions – While observations gleaned from this study may serve as a benchmark for evaluating communication practices in academic libraries, further research is necessary to understand how factors within an academic library, its parent institution, or the profession at large may contribute to this decision making process.
A INFLUÊNCIA DO MODELO HIGIENISTA FRANCÊS NO PLANEJAMENTO URBANO DE BELO HORIZONTE NO FINAL DO SÉCULO XIX E INÍCIO DO SÉCULO XX
Authors: Brandão Euclides Dayvid Alves , Luiz Izabella Taranto , Souza Antonio Carlos da Silva
Published: June 2018

Este trabalho pretende compreender os problemas gerados pelo Planejamento Urbano baseado no modelo francês higienista quando da construção da capital mineira Belo Horizonte para atender as demandas da sua população. Estabelecendo um paralelo entre o levantamento bibliográfico de planejamento urbano e os mapas do antigo Arraial Del Rei e da Belo Horizonte da década de 1940, demonstrando a exclusão da população à infraestrutura da nova capital.

 

ABSTRACT

This work intends to understand the problems generated by the Urban Planning based on the hygienist French model during the construction the capital Belo Horizonte to meet the demands of its population. Drawing parallels between the literature of urban planning and the maps the ancient Arraial Del Rei and Belo Horizonte in the 1940s, demonstrating the exclusion of the population the new the capital infrastructure.
SÍNTESE E CARACTERIZAÇÃO DE NANOCOMPÓSITOS POLIMÉRICOS REFORÇADOS COM VERMICULITAS
Authors: Ferreira Janilson Alves , Oliveira Júnior Antônio Italcy de , Sobrinho Ledjane Lima
Published: June 2018

As propriedades de proteção de um material por um revestimento polimérico são enfraquecidas por mecanismos térmicos e químicos, onde a reação de corrosão é favorecida na interface entre o material protegido e o material protetor. Para isso, faz-se necessário o estudo de sínteses menos complexas e eficientes de materiais que atuem com essa finalidade. Este trabalho busca analisar o efeito das propriedades térmicas, mecânicas e morfológicas na resina epóxi, a partir da adição de argila vermiculita paraibana nos teores de 1 e 3% em massa numa matriz à base de resina epóxi, após o processo de organofilização das argilas, que se apresentam naturalmente hidrofílicas e sem afinidade à compostos orgânicos. Os resultados mostraram uma estabilidade na temperatura de degradação do nanocompósito e um impressionante aumento na temperatura de transição vítrea. Houve também uma melhora na resistência à tração em relação a resina não modificada, sugerindo a intercalação polímero/argila, estrutura essa, comprovada a partir da técnica de Microscopia Eletrônica de Varredura (MEV).

 

ABSTRACT

The protective properties of a material by a polymer coating are weakened by thermal and chemical mechanisms, where the corrosion reaction is favored at the interface between the protected material and the protective material. For this, it is necessary to study less complex and efficient syntheses of materials that act for this purpose. This work aims at analyzing the effect of thermal, mechanical and morphological properties on the epoxy resin, from the addition of vermiculite paraibaan clay at 1 and 3% by mass in a matrix based on epoxy resin, after the organophilization process of the clays, which are naturally hydrophilic and have no affinity for organic compounds. The results showed a stability in the degradation temperature of the nanocomposite and an impressive increase in the glass transition temperature. There was also an improvement in the tensile strength in relation to the unmodified resin, suggesting the polymer / clay intercalation, a structure that was proven using the Scanning Electron Microscopy technique (SEM).
Research and Application of SO2 Concentration Monitoring Algorithm in Flue Gas
Authors: Wang Qinqin , Su Xiaohui
Published: June 2018

This paper mainly focuses on the concentration calculation of SO2 in flue gas. There are many methods for smoke detection. First of all, this paper mainly introduces the basic Differential Optical Absorption Spectroscopy technology. Then, in order to solve the problem of overlapping absorption between different gases in the flue gas, this paper use cyclic iteration algorithm to measure the concentration of SO2. It is concluded that the basic DOAS algorithm has a large error for the concentration measurement of mixed gas with overlapping absorption, the he error is above 25%. However, the cyclic iterative algorithm has a good effect on processing with it which can get a more stable result after three iterations, and the measurement error can be controlled finally within 2%.
A Review on Prognostics and Health Management
Authors: Nannan Hu , Xiaohao Su , Liu Baolong
Published: June 2018

The health management of complex equipment is crucial to ensure the reliability, maintainability and safety of complex equipment. This paper introduces the basic concept and research connotation of prognostics and health management (PHM), analyzes the significance of PHM technology in equipment maintenance. For the fault prediction architecture and method, this paper focuses on the discussion, analysis, and summarizes the current research’s hot spots and existing technical difficulties. Finally, the future research directions are also prospected.
A New Non-Singular Terminal Sliding Mode Control and Its Application to Chaos Suppression in Interconnected Power System
Authors: Nian Wang , Chen Hui , Ding Dawei
Published: June 2018

Interconnected power system is a typical nonlinear dynamical system, it will cause great harm to the interconnected power system when the chaos occurred. This paper analyses the nonlinear dynamical behavior of the interconnected power system with a uncertain electromagnetic disturbance amplitude, and the influence of the electromagnetic disturbance amplitude on the stability of the system is obtained. Thus, this paper proposes a novel non-singular terminal sliding mode control to restrain the chaos, then the system will reach a stable state in a fixed time. According to the theoretical analysis, by introducing the saturation function, the control method can solve the singularity problem in the sliding mode control, and the interconnected power system will be stable in a short time when it’s in chaos. The simulation prove the correctness of the method.
Quadrotor Formation Control Method Based on Graph and Consistency Theory
Authors: Sen Yang , Leiping Xi
Published: June 2018

This paper introduces graph and group system consistency theory and puts forward a quadrotor formation control method. The quadrotor is described as a second-order integrator dynamic system, and the relative position deviation of different quadrotors is used to describe formation. According to the communication topology relationship between quadrotors, the formation is modeled by graph theory. The fusion of the pilot-follow and graph theory method is analyzed, and a second-order coherence algorithm with a pilot is presented. With this algorithm, the quadrotors can complete behaviors just as formation rally and formation mobility etc. Finally the paper verifies the availability of the proposed method through simulation tests.
An Improved Algorithm of the Collision Detection Based on OBB
Authors: Chaoyang Geng , Fenli Gao
Published: June 2018

Collision detection plays a vital role in improving the sense of immersion and realism in virtual environment. The bounding box is the most basic collision detection algorithm, The OBB intersect test tightness and can able to significantly reduce the number of bounding volume. and try to occupy less storage space. Propose a bounding box of direction cylindrical So it can be improved though surrounded objects more close, then improve the efficiency of collision detection.
Research on the Construction of Sports Resources Information Platform Based on Big Data
Authors: Shuangming Wang , Jianwei Shi , Shiqiu Fu , Wanlin Xu
Published: June 2018

The rapid development of communication technology such as big data makes the integration and application of sports resource information become the key of sports informatization construction. The construction of sports resources information big data platform is of great significance to the integration of sports resources and the sharing of sports resources. The subject explores the related theory of sports resources, studies the present situation of the application of sports resources, constructs the overall construction framework of sports resources information big data platform, analyzes and designs the functions of each subsystem, and discusses the performance evaluation of sports resources information big data platform.
Research of Distributed Control System for Oilfield Oil Pump Based on PLC and LAN
Authors: Yang Shengquan , Chen Gong
Published: June 2018

In order to change the current bad situation such as the high cost of manpower, the failure to deal with the fault in time and the low management efficiency, etc. in oilfield oil pump measure and control, this paper puts forward the research and development of oilfield oil pump distributed control system based on PLC and LAN. Firstly this paper describes the operation principle of oil pump equipment and gives its network topology model. Secondly it designs the system macro distributed structure framework with 4 layers: Pump layer, PLC layer, IPC layer and RCC layer in detail. Finally the paper discusses the design of the software system including the PLC on-site field measure and control software subsystem, the IPC local session software subsystem and the RCC remote management software subsystem.
Advanced Dynamic Autonomous Knowledge Learning Method for Distance Learning
Authors: Fu Yanfang , Li Xing , Feng Xueyao , Ma Jing
Published: June 2018

As the manufacturing of vast amount of information transmits at an unprecedented rate, traditional learning is no way to meet the needs of open learning and lifelong learning, how can distance learning be used to help us study become a problem to think about. Distance learning requires improvement of interactivity and initiative to achieve their aptitude. Using a variety of formats data, learners master the initiative in the learning process, it is not easy to lead to deviation from the learning goals phenomenon. To this end, in order to solve this problem, we use the basis of ILTMK theory and distributed interactive technology to introduce the active learning factors and propose a dynamic autonomous knowledge learning model and build its model’s simulation running environment and related mechanism. Through simulation experiment, we can verify the effectiveness of the autonomous learning methods.
Simulation of Self-similarFlowBased on Fractal Gaussian Noise Method
Authors: Jie Li , Ying Lu , Junyong Tang
Published: June 2018

The conventional network traffic flow models are mostly based on Poisson model. With the continuous development of network services, studies found that the actual network traffic has a long-range dependence (LRD) now and in a very long time, which is a kind of self-similarity. In this paper, RMD and Fourier algorithm were adopted to simulate and analyze a self-similar model of FGN. They generated the necessary sequence of self-similar traffic. Then the article uses R/S method to verify H value of the generated sequence of self-similar traffic in order to verify the self-similarity of the self-similar traffic sequence. The existence of self-similarity is verified by experiments, and the advantage and disadvantage of RMD and Fourier algorithm are analyzed.
Research on the Application of Political Teaching Under the Network Platform
Authors: Yingli Pan
Published: June 2018

With the advent of the era of network, information technology has penetrated into many fields such as politics, economy, culture and so on. Human’s production mode, life style and learning way have changed greatly. The traditional educational mode has been unable to meet the diverse needs of students. Our educational reform and development are facing unprecedented challenges. The driving point of educational reform is to drive educational modernization with educational information. In this context, the ideological and political theory needs a new teaching model to make up for the shortcomings of the traditional teaching model. After a series of explorations, it is found that the teaching mode, which is based on classroom teaching and the network teaching is supplemented, is a new model in line with the requirements of the times. The network teaching platform of the ideological and political course has emerged as a new part of the network teaching.