bluuebunny/crossref_metadata_2025 huggingface dataset:
Invasive fusariosis with cutaneous manifestation during chemotherapy treatment of a patient with acute lymphoid leukemia: case report
Authors: Bandeira Fernanda Letícia Reis , Cristino Joseir Saturnino , Crispim Myuki Alfaia Esashika , Mendes Ana Galdina dos Reis , Ferreira Cristina Motta
Published: February 2024

Invasive fungal infections have a high mortality rate, especially when they affect immunocompromised patients. The objective of this article is to report a case of a patient affected by a rare fungal infection of the genus Fusarium spp., during treatment for acute lymphocytic leukemia, covering everything from clinical and laboratory aspects to diagnosis. When dealing with an invasive Fusarium spp. infection, the patient's clinical outcome largely depends on the resolution of immunosuppression, particularly the recovery of neutrophils in neutropenic patients.
Chrysanthemum Classification Method Integrating Deep Visual Features from both the Front and Back Sides
Authors: Chen Yifan , Yang Xichen , Yan Hui , Liu Jia , Jiang Jian , Mao Zhongyuan , Wang Tianshu
Published: February 2024

Chrysanthemum morifolium Ramat(hereinafter referred to as Chrysanthemum) is one of the most beloved and economically valuable Chinese herbal crops, which contains abundant medicinal ingredients and wide application prospects. Therefore, identifying the classification and origin of Chrysanthemum is important for producers, consumers, and market regulators. The existing Chrysanthemum classification methods mostly rely on visual subjective identification, are time-consuming, and always need high equipment costs. A novel method is proposed to accurately identify the Chrysanthemum classification in a swift, non-invasive, and non-contact way. The proposed method is based on the fusion of deep visual features of both the front and back sides. Firstly, the different Chrysanthemums images are collected and labeled with origins and classifications. Secondly, the background area with less available information is removed by image preprocessing. Thirdly, a two-stream feature extraction network is designed with two inputs which are the preprocessed front and back Chrysanthemum images. Meanwhile, the incorporation of single-path residual connections and cross-path residual connections is employed to extend the receptive field of the network and fully fusion the features from both the front and back sides. Experimental results demonstrate the proposed method outperforms existing methods, which gain higher accuracy and stability. The proposed method presents an effective and dependable solution for identifying the classification and origin of Chrysanthemum. Code and data are available at https://github.com/dart-into/CCMIFB.
Artificial Intelligence in Healthcare: A Closer Look at ChatGPT's Usages and Challenges
Authors: khonakdar kimia , moradimajd parisa , babajani alireza , sedighmaroufi shahnam , sajadi Atiyeh sadat
Published: February 2024

Background
Artificial intelligence, a rapidly advancing field, is characterized as a branch of computer science capable of human-like thinking and actions. Among the extensively utilized forms of AI is Natural Language Processing (NLP), enabling machines to think and communicate in a manner resembling humans. Numerous chatbots, such as Jasper chat, DialoGPT, Replika, and ChatGPT, have been introduced as part of these advancements.
Methods
The study employs a scoping review methodology, searching five databases with specific keywords related to ChatGPT and healthcare. Inclusion and exclusion criteria are defined, resulting in 17 relevant articles for analysis. The research process involves a thorough review, removal of duplicates, and quality assessment. Data analysis is conducted using content analysis.
Results
The 17 articles are categorized into three themes: Education & Evaluation, Research & Publication, and Care & Cure. Subthemes within each category detail the usages and challenges of ChatGPT in various contexts, including education, research, and patient care.
Conclusion
The paper evaluates the impact of ChatGPT in different domains, emphasizing its positive influence on data availability, learning experiences, and research processes. However, ethical concerns such as plagiarism, biases, and potential risks in patient care are identified. The authors advocate for the responsible use of ChatGPT, suggesting solutions like academic integrity rules and staff training.
Composition and variations diet of the European eel Anguilla anguilla (Linnaeus, 1758) in Tonga Lake, North-East Algeria.
Authors: DERBAL Farid , ARIBA Souheila
Published: February 2024

Despite the economic and ecological status of the European eel Anguilla anguilla throughout the North African coasts, this species remains little known. This study aims to provide information on the trophic habits of the fraction of the population that occupies Tonga Lake, a wetland located in Algeria extreme East. During one year (January - December 2009), a total of 477 eels (26
Heavy metals transfer in leaves, stem and roots of olive tree near roads in the region of Sfax (Tunisia) and their impact on physiological characteristics
Authors: Mbadra Chaker , Gargouri Kamel , Mbarek Hadda Ben , Trabelsi Lina , Soua Nabil , Ncube Bhekumtheto , Chaabouni Semia Ellouz
Published: February 2024

In this study we try to evaluate the accumulation of heavy metals, including Pb, Zn, Cu and Cr in the soil, the entry into plants, and the effect on the physiological and biochemical processes of olive tree. We try to study the contamination of the leaves, stem and roots of olive trees collected from 24 sampling sites throughout three roads in the region of Sfax, Tunisia. To better study this contamination, we used two contamination indices, the accumulation and translocation factor. For Gremda road, Pb and Zn contamination does not exceed 50m. For Tunis road, contamination of leaves stems and roots by Pb and Cr arrived up to 50m in the eastern and western side of the road. In contrast, Zn contamination reached 50m in the eastern and 25m in the western side of road. Likewise, metal contamination affects the roots and leaves of Manzel Chaker olive trees at a distance of 3m but this contamination does not affect the physiological and biochemical mechanisms of the latter. The contamination of sites near Tunis and Gremda roads affects the chlorophyll assimilation of olive trees planted in these sites but, the chlorophyll contents of Manzel chaker sites are less affected. On the other hand, for soluble sugars, the olive leaves close to Manzel Chaker and Tunis roads recorded higher sugar contents than those of Gremda sites. The leaves of olive trees in the sites close to Gremda and Tunis roads showed a weakened antioxidant activity compared to that recorded in the control sites.
RQPoA: A random quantum PoA Consensus Mechanism in Blockchain Based on Quantum Methods
Authors: WANG ZHUO , Li Jian , Liu Ang , Ota Kaoru , Dong Mianxiong , Chen Xiubo
Published: February 2024

As a distributed network, the operational efficacy of a blockchain system relies heavily on the consensus mechanism it adopts. Among the mainstream consensus mechanisms in blockchain, proof-of-authority (PoA) is appealing for its post-quantum security and block generation efficiency and, therefore, has gained academic attention. Nevertheless, the traditional PoA faces three major problems: (1) Low decentralization. The allocation of bookkeeping rights has a low degree of decentralization in the blockchain network. (2) Low availability. The total exposure of the leader node makes it susceptible to centralized attacks, leading to a single point of failure (SPOF) dilemma and reducing the availability of the entire blockchain system. (3) Non-robustness (low fault tolerance). Generating a new block must be done jointly by all validator nodes, with this voting process potentially delayed due to invalid voter participation. To address these issues, this paper improves PoA and proposes a new consensus mechanism scheme, the random quantum proof of authority (RQPoA). First, RQPoA develops the leader node election algorithm with a verifiable delay function (VDF) to realize fair and impartial leader node selection, enforcing the blockchain’s decentralization level. Second, RQPoA adopts the multi-party quantum secret sharing protocol to share the leader node’s identity among validator nodes confidentially. This strategy eliminates SPOF caused by the leader node, increasing the blockchain system availability. Third, RQPoA incorporates a candidate block voting protocol based on a quantum threshold signature to complete the block proposal, which is fault-tolerant and thus enhances the blockchain system's robustness. A security analysis of RQPoA demonstrates its security, efficiency, and better fault tolerance than related quantum consensus mechanisms. In conclusion, the RQPoA makes a useful exploration for researching secure consensus mechanisms in the post-quantum era and enriches the related research.
Study on Workability and Durability Characteristics of Self- Compacting Geopolymer Concrete Composites
Authors: Jeyaseela J , Engineering S Sowmya Civil , Engineering M Shahul Hameed Civil
Published: February 2024

Increase in production of cement causes the huge amount of carbon-dioxide emission which results in global warming. In order to overcome this problem many researchers put their effects to achieve the optimum strength and durability of concrete by replacing the cement with fly ash and when it combines with the alkali activator solution it becomes geopolymer concrete. These concretes have the ability to fail due to lack of compaction. Self-compacting concrete is the innovative way of concreting; it can be compressed into every corner of formwork by means of its own weight. In order to trounce poor compaction and global warming; the new way of concreting is introduced as self-compacting geopolymer concrete. This concrete has two limitations such as delay in setting time and heat curing to gain strength. The present research intended to set right these limitations by replacing the fly ash by OPC up to 20% on a mass basis. Also an attempt to make to use of manufactured sand instead of using river sand due to scarcity of river sand and natural resource depletion. The durability of self-compacting geopolymer concrete composites is based on the tests conducted such as acid attack, sulphate attack and Sorptivity.
Improved Diabetic Retinopathy Severity Classification Using Squeeze-and-excitation and Sparse Light Weight Multi-level Attention U-net With Transfer Learning From Xception
Authors: Bhandari Sachin , Pathak Sunil , Jain Sonal Amit , Agarwal Basant
Published: February 2024

Diabetic Retinopathy (DR) is a leading cause of vision loss among diabetic patients. Early detection and accurate severity classification of DR play a crucial role in preventing its progression and managing patient care effectively. In this paper, we propose an improved DR severity classification approach that leverages advanced architectural enhancements and transfer learning techniques. Specifically, we introduce a novel model named Xception Squeeze-and-Excitation Sparse Lightweight Multi-Level Attention U-Net (XceSE_SparseLwMLA-UNet) for DR severity classification using fundus images from the Messidor 1 and Messidor 2 datasets. Our proposed XceSE_SparseLwMLA-UNet architecture combines the benefits of multiple innovations, including the Squeeze-and-Excitation (SE) mechanism for feature recalibration, the Sparse Lightweight Multi-Level Attention (SparseLwMLA) mechanism for capturing contextual information, and transfer learning from the Xception architecture to enhance feature extraction. The SE mechanism enables the model to emphasize important features by adaptively recalibrating channel-wise feature responses. The SparseLwMLA mechanism facilitates efficient integration of multi-level contextual information, enhancing the model's ability to recognize complex patterns associated with different DR severity levels. Furthermore, the utilization of transfer learning from the Xception architecture allows our model to leverage pre-trained weights learned from a large-scale image dataset, enabling the network to better generalize to the task of DR severity classification, even when trained on large medical imaging data. Our experimental results demonstrate the superiority of the SE_SparseLwMLA-UNet model, achieving significantly improved higher accuracy and multi-class higher F1 scores for DR severity classification. The color-coded segmentation outputs generated by the model provide interpretable visual representations, aiding medical professionals in understanding the severity levels identified by the algorithm. Hence the proposed SE_SparseLwMLA-UNet model holds promise for enhancing early diagnosis and management of DR, contributing to better patient care and visual health outcomes.
Isolation, biochemical characterization and comparative study of diagnostic methods for Helicobacter pylori infection from dyspepsia patients
Authors: Mujtaba Ahmed , Ibrahim Muhammad Suhail , Parveen Sana , Sarwar Noreen , Alsagaby Suliman A. , Memon Anjuman Gul , Raza Muhammad Ahsan , Abdelgawad Mohamed A. , Ghoneim Mohammed M. , Alhossan Abdulaziz , Abdulmonem Waleed Al , Hussain Muzzamal , Yehuala Tadesse Fenta
Published: February 2024

The success of any therapy especially against H. pylori depends upon the prompt and authentic diagnosis. This research was designed to study the patients with dyspepsia for possible H. pylori infection and to compare different commonly used diagnostic techniques. Ninety-Six gastrointestinal biopsies and blood samples were collected after obtaining an informed consent having gastro duodenal symptoms. The obtained samples were tested and compared by using different invasive and non-invasive diagnostic tests. The results showed that 40 (41.67%) subjects were positive for H. pylori in RUT and histopathology. Contrariwise, 46 subjects were positive for ELISA test against anti-IgA and IgG. Culture tests showed 18 biopsies against the bacteria. On the other side, tests like endoscopic examination, urease, catalase and oxidase further confirmed the findings. A high resistance was observed to antibiotics like kanamycin (77.78%), amoxicillin (88.89%) and polymyxin B (100%) respectively. A gene (Cag A) was also detected by using molecular technique and 18 subjects emerged as positive. Sensitivity/specificity (%) of used diagnostic method was 95/77 for histology, 100/83.5 for rapid urease, 85.7/90 for gram staining, 100/66.6 for IgG serology, 100/79.5 for IgA serology, 100/75.0 for PCR, 100/79.04 for a combination of RUT and IgG serology and 100/92.4 for a combination of RUT, gram staining and IgG serology. It is concluded that PCR appeared the most reliable test among different diagnostic methodologies. However, the higher sensitivity and specificity values were also observed for other tests. Hence, comparative detection methods should be used for accurate detection rather than a single methodology.
Unique metabolite profile of Pacific white shrimp Litopenaeus vannamei intestine after diverse Vibrio parahaemolyticus vp5 challenges
Authors: Sutanti Sutanti , Sukenda Sukenda , Widanarni Widanarni , Alimuddin Alimuddin , Aliah Ratu Siti
Published: February 2024

The Pacific white shrimp Litopenaues vannamei is the most widely cultivated shrimp in the world, particularly in Indonesia. Vibrio parahaemolyticus is a bacterial pathogen that severely affects shrimp, causing extensive economic losses in L. vannamei culture. This study is the first report of the effects on the L. vannamei intestine after Vibrio parahaemolyticus Vp5 local isolate challenge with different concentrations using a metabolomics approach. Healthy shrimp cultured weighing 2±0.5 g were challenged using the intramuscular method with four different concentrations (103, 104, 105, and 106 cfu/ml) of V. parahaemolyticus Vp5 then subjected to gas chromatography-mass spectrometry (GC-MS) non-targeted metabolomics analysis. Out of the five groups, three groups (104, 105, and 106 cfu/ml) demonstrated significant mortalities (P<0.05). A total of 176 metabolites were annotated from shrimp samples and targeted to principal component analysis (PCA) and heatmap analysis. Metabolomic results showed that Vibrio parahaemolyticus Vp5 changes the metabolite profiling. Ten volatile metabolites showing high variable importance in projection (VIP) scores were diethyl phthalate, 2-propanol, 1, 1’-oxybis; cyclopenta [g]-2-benzopyran, 1-propanol, 2-(2-hydroxypropoxy); 1, 2-benzenedicarboxilic acid, heneicosane, pentacosane, docosane, dibutyl phthalate, dan cyclopentadecanone. Diethyl phthalate was the conserved metabolite both in the Control and different concentrations challenges. The healthy shrimp have a significantly higher concentration of pentacosane compared to the infected shrimp (P<0.05). Pentacosane was lost abundance in acute infection of V. parahemolyticus Vp5. The differential metabolites (DMs) was detected in intestine of L. vannamei, exhibiting that this bacteria may disrupt the immune system and cause metabolic disorder in the shrimp. Our findings showed that pentacosane may serve as essential fragrant for healthy shrimp and candidate markers to indicate the acute condition caused by the infection.
Coagulation hallmark indicators of menorrhagia in a comparative study between menorrhagic and healthy women attending Bungoma County Referral Hospital in Kenya
Authors: Marabi Phidelis Maruti , Musyoki Stanslaus Kiilu , Monari Fred , Kosiyo Paul , Ouma Collins
Published: February 2024

Background
Despite the significant burden of menorrhagia among women in Western Kenya, it remains unknown whether coagulation disorders are one of the important underlying causes of this condition in the region. This study evaluated the differences in coagulation profiles, associations between menorrhagia and coagulation profiles and compared the morphological features of platelets between menorrhagic patients and healthy women attending Bungoma County Referral Hospital in Kenya.
Methods
A comparative cross-sectional study of women [n = 428 (214 per group), aged 18–45 years] was performed. A Humaclot junior analyzer was used to evaluate prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (PT), fibrinogen, and the international normalized ratio (INR). The platelet count was determined using Celtac F ME822K, and Leishman-stained blood films were analyzed using an Olympus light compound microscope. The Chi-square test was used to analyze categorical descriptive data. The Mann‒Whitney U test was used to compare the data between the menorrhagic and control groups. Binary logistic regression was applied to determine the association between coagulation profile and menorrhagia incidence. The platelet morphological characteristics were reported as frequencies and percentages. Statistical significance was set at p≤0.05 indicated statistical significance.
Results
The results showed that a history of bleeding disorders (p < 0.0001), PT (p < 0.0001) and INR (p < 0.0001) were greater in menorrhagic women than in non-menorrhagic women. Menorrhagia was significantly associated with a high PT [OR = 2.129, 95% CI = 1.658–2.734; p < 0.0001] and INR [OR = 7.479, 95% CI = 3.094–18.080; p < 0.0001]. No morphological abnormalities in the platelets were observed in either healthy or non-menorrhagic women.
Conclusions
Family history of bleeding disorders, increased PT and INR are the hallmark indicators of menorrhagia in western Kenya. Therefore, routine assessment of the coagulation profile and history of bleeding disorders is critical for the diagnosis and management of menorrhagia.
X-CTCANet：3D spinal CT reconstruction directly from 2D X-ray images
Authors: Gao Tian , Zhang Lei , Wang Zechang , Shi Zhengjin , Ying Yuhan , Li Andi , Wu Chen , Song Guoli
Published: February 2024

2D X-ray images are extensively employed for intraoperative navigation and localization owing to their high imaging efficiency, low radiation risk, and affordability. However, this method can only yield overlapped anatomical information from a restricted number of projected views. Conversely, intraoperative CT scanning techniques, offering 3D images, elevate the risk of radiation exposure for both patients and healthcare professionals. For this purpose, we propose a V-shaped convolutional attention mechanism network (X-CTCANet) designed for X-ray reconstruction of CT images. The network enhances reconstruction performance by promoting task consistency in encoding-decoding, minimizing semantic differences between feature mappings. Additionally, it introduces an adaptive convolutional channel attention (CCA) mechanism to compel the network to prioritize essential feature regions. Experimental results demonstrate the successful CT image reconstruction from spine X-rays using X-CTCANet, achieving an SSIM value of 0.805 and a PSNR value of 34.64 dB. This underscores the considerable potential of accurate 3D CT reconstruction from 2D X-ray images in offering image support for surgical robots.
Dependence of micro-structure regularity on the degree of molecular asymmetry in polynorbornene derivatives
Authors: Pan Rui , He Shuyin , Qiu Sili
Published: February 2024

Although the correlation between the regularity of micro-structures and the length of side chains has been widely reported, experiments still require precursors of polynorbornene derivatives due to the complex inter-and intra-chain interplay. This research utilizes hydrogen bonding between amide groups to design molecular models of polynorbornene derivatives (PNbs). The PNbs are abbreviated as Pm-8, where “m” indicates the amount of methylene groups as spacers in the side chain, and “8” refers to the oxyoctyl tail. The aim is to obtain a gradual variation of inter-and intra-chain interplay for further elucidation. Based on an analysis of spatial descriptors, mean square displacement (MSD), and radial distribution function (RDF) by using molecular mechanics (MM) and molecular dynamics (MD) methods, it is found that the asymmetry of side chains plays a more significant role in determining micro-structural regularity than the length. Highly asymmetric side chains are favorable for forming inter-chain hydrogen bonding, promoting interdigitation, and creating a larger scale of regularity in P8-8 and P10-8 molecules. In contrast, the relatively symmetric side chains tend to form intra-chain bonding, resulting in limited regularity within P2-8 and P4-8 molecules. Therefore, unlike regular structures that usually require symmetrical molecules, polynorbornene derivatives with asymmetric side chains have achieved highly ordered orthorhombic lattices in experiments. This study aims to offer an alternative approach to screening effective precursors of long-side chain polymers by means of semi-quantitative geometric parameters, providing a fresh perspective on the subject.
The Interactions and Biological Pathways Among Metabolomics Products of Patients with Coronary Heart Disease Analyzed Using the Bioinformatics Methods
Authors: Chu Chun , Liu Shengquan , Nie Liangui , Hu Hongming , Liu Yi , Yang Jun
Published: February 2024

Background: Metabolome products are small molecules resulting from cellular metabolism. Studies has used advanced methods of molecular detection to analysis samples of ill patients. Based on bioinformatics analysis, the interactions and biological pathways among metabolome products in patients with coronary heart disease (CHD) were investigated.
Methods: Related studies focusing on the metabolomics analysis of patients with CHD published on CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, Nature, Web of Science, Spring, and Science Direct were retrieved. The metabolites in the literature were analyzed statistically and summarized, the differential metabolites were selected and their pathways were analyzed based on the Kyoto Encyclopedia of Genes and Genomes (KEGG). Molecular annotation of metabolites and related enzymes or transporters were analyzed with the HMDB. Their related properties were visualized using the metPA.
Results: A total of 12 literatures which satisfying the criteria for enrollment were included here. Total 136 metabolites related to CHD were preliminarily screened, and 83 effective metabolites were obtained after the unrecognized metabolites were excluded. 45 pathways were involved. Through the topology analysis (TPA) of pathways, their influence values were calculated, and 14 major metabolic pathways were selected, which were phenylalanine (Phe), tyrosine and tryptophan biosynthesis (TTB), Aminoacyl-tRNA biosynthesis (ATB), and arginine biosynthesis (ABS). These results indicated that glucose metabolism, fatty acid (FA) metabolism, amino acid (AA) transporting to proteins to cells, and tricarboxylic acid (TCA) cycle were involved in the occurrence of CHD.
Conclusion: this study showed cellular and molecular pathways involved in the process of CHD. This information can be used for different drug development and diagnostic studies.
Rare Presentation of Acute Lower Limb Ischemia: Saddle Aortic Embolus with Paraplegia - Case Report
Authors: Almadwahi Nabeel Y. , Alshujaa Mohamed A. , Al-Hashedi Aref A. , Jowah Haitham Mohammed
Published: February 2024

Introduction:
This case report presents a unique and noteworthy occurrence of acute lower limb ischemia (ALI) accompanied by paraplegia in a 60-year-old male patient with a medical history of diabetes mellitus, hypertension, and ischemic heart disease. The novelty of this case lies in the rare association of ALI with paraplegia, which is an unusual and infrequently reported condition.
Case presentation:
A patient who underwent coronary artery bypass graft (CABG) surgery presented 12 days post-surgery with sudden onset right lower limb pain followed by paralysis in both lower limbs. Initially, Guillain-Barré syndrome (GBS) was suspected; however, further evaluation revealed occlusion in the abdominal aorta, common iliac artery, and external iliac arteries. The patient's management involved prompt diagnosis, administration of intravenous heparin, bilateral leg fasciotomy, and thrombectomy. These interventions resulted in the restoration of pulses and improvement in the patient's condition. Nonetheless, postoperative complications in the form of acute kidney injury were observed.
Conclusions
In conclusion, this case highlights the importance of maintaining a broad differential diagnosis when encountering rapidly progressing lower limb paralysis, especially in patients with vascular risk factors. Timely diagnosis and intervention in patients with acute limb ischemia can significantly impact patient outcomes. A multidisciplinary approach involving vascular surgeons, interventional radiologists, critical care specialists, and neurologists is crucial for optimizing patient outcomes in complex scenarios.
Manipulating Spin-Torque Dynamics in Atomic Media Using Kerr Field with Two-Wave Interference
Authors: Tariq Muhammad , Khan Abuzar
Published: February 2024

In this article, Spin density and Torque of two interfering waves are controlled and manipulated by applying two interacting control fields in which one is the Kerr field with Rabi frequency Ω2 and a probe field using a four-level N-type atomic configuration of Rubidium-87 isotope. The spin density of light can be controlled coherently in the atomic medium by electromagnetically induced transparency (EIT). When the strong interacting control fields and the weak probe field are applied to the atomic medium, the Rubidium atoms become transparent to the probe field. It is due to the control fields that ”dress” the atoms, creating a new energy state that the weak probe field can interact with. As a result, the weak probe field can pass through the Rubidium atomic medium without being absorbed. Substantial variations can be seen in the electric SAM and Torque of two interfering waves with variations in the angle β between the two interfering waves, the Rabi frequencies of the control fields, the detuning of the probe field, and the phase difference δϕ between waves. By introducing these changes of parameters in the atomic medium, the spin density of two interfering waves can be made to rotate in a specific direction or at a specific rate. The parameters of control fields and probe field detuning play an essential role in the modification of electric SAM and electric spin vector field distribution of the probe field. The modified work of this manuscript is useful for Quantum computing, Optical communication, Quantum information processing.
Teacher noticing: exploring the nexus between effective implementation and academic performance of basic 12 students in geometry in Builsa South District
Authors: Enoch Enoch Kabinaa
Published: February 2024

Teachers' noticing has become a crucial topic in recent studies because many believe that the teacher’s noticing, interpretation, and attention to students during lesson activities have a great impact on students’ learning and academic performance. This study therefore aimed to explore the nexus between effective noticing implementation and the academic performance of basic 12 students in geometry. The study was purely quantitative descriptive research with a population and sample size of 360 and 186, respectively. A simple random sampling technique was used to select the sample members. Data for the study were collected using a questionnaire survey and a Geometry Achievement Test. Data analysis was done using SPSS’s descriptive procedures and the simple linear regression model. The study found that: 1) there was a significant relationship between effective implementation of noticing in teaching and students’ academic performance in geometry, p(.019). 2). the study recommended that teachers should effectively implement their noticing skills during geometry and mathematics lessons so as to enhance students’ learning and academic performance.
Gravity model applied to intra-community trade in SADC and COMESA
Authors: Sandambi Nerhum , João Mário Augusto Caetano
Published: February 2024

We studied trade flows between the member states of SADC and COMESA, analyzing 27 countries that make up the two regions. In particular, we used a set of data from 1999-2022, specifying 4 different models, and the Hausman-Taylor estimator proved to be relevant in explaining intra-community trade between the two economic integration zones. However, the results suggest that there are positive impacts in the SADC countries. The pull factors translated into physical distance are relevant to intra-community trade between the SADC and COMESA member states. There is strong negative evidence related to the countries' industrial capacity, although there are negative impacts, mainly associated with the countries' low level of industrialization. On the other hand, external influence negatively affects intra-Community trade flows. We also estimated an alternative model, and the results show strong evidence of trade potential in the countries of South Africa, Namibia, Tanzania and Congo Brazzavile. On the other hand, SADC has lower trade potential compared to COMESA, for example, and we measured the intensity of trade between the member states and found higher trade intensity between Angola, Namibia and South Africa and significantly higher trade intensity between South Africa, Botswana, Lesotho, Malawi and Mozambique, i.e. considering bilateral intra-community trade.
JEL classification: F00; C01; C02; C33 & C40.
Unravelling the Metastatic Niche in Breast Cancer Patients with Bone Metastasis through Single-cell RNA Sequencing
Authors: Li Xiangyu , Gao Ziyu , Yang Meiling , Yang Ciqiu , Yang Dongyang , Cui Wenhui , Wu Dandan , Zhou Jie
Published: February 2024

Breast cancer (BRCA) is characterized by a unique metastatic pattern and often presents with bone metastasis (BoM), which poses significant clinical challenges. This study employed single-cell RNA sequencing (scRNA-seq) and TCGA data analysis to compare primary tumor (PT), lymph node metastasis (LN), and BoM data. Our investigation identified a metastatic niche in BoMs marked by an increased abundance of cancer-associated fibroblasts (CAFs) and a reduced immune cell count. A distinct subtype (State 1) of BRCA BoM cells associated with adverse prognosis was identified. State 1, characterized by heightened stemness traits, may represent an initiation phase for BoM in BRCA. Complex cell communications involving tumor, stromal, and immune cells were revealed. Interactions between FN1, SPP1, and MDK correlate with elevated immune cells in the BoM. CD46, MDK, and PTN interactions drive myofibroblast activation and proliferation, contributing to tissue remodelling. Additionally, MDK, PTN, and FN1 interactions influence FAP+ CAF activation, impacting cell adhesion and migration in BoMs. These insights deepen our understanding of the metastatic niche in breast cancer BoMs.
Otra manera de indagar y transitar. Una perspectiva metodológica distinta
Authors: Molina Gómez Carlos Alberto
Published: February 2024

Este artículo, es bastante distinto a los mal llamados artículos científicos. Y digo mal llamados artículos científicos porque ese tipo de artículos no muestran nada de científico por responder a los cánones establecidos por los editores de revistas que le dicen al investigador qué y cómo publicar su trabajo. Editores y revistas a quienes no les interesa sino promocionar sus marcas para la venta de suscripciones. Y distinto porque se concentra en mostrar, después de varias experiencias indagativas, otra episteme de la metódica. Sólo se concentra ahí. La metódica, en una indagación, no se reduce a una mera tecno instrumentación. La metódica la asumimos no cómo una parte o momento de la indagación (no es el cómo lo hago) sino cómo un enfoque filosófico que problematiza temas u objetos que la gente acepta como verdad o como hecho natural y que han sido construidos durante un determinado momento de la historia (desde dónde lo hago). De esta episteme hablaré aquí y se soporta en lo que se podría reconocer como ontología del presente. Del presente porque este presente es el territorio menos habitado por nosotros por estar con un pie en el pasado y otro pie en el deber ser eternizado. Este artículo tiene entonces dos momentos. El primero muestra, con citas textuales, una posible línea argumentativa que a manera de memes soporta esa manera de proceder en la indagación. Y el segundo momento deja insinuada otra posibilidad de operar para llegar a la problematización, la hipótesis de trabajo, la pregunta de indagación y el objetivo general. De manera simultánea e interdependiente, como en una especie de enmarañamiento, la problematización se rodea de argumentos teóricos permitiendo la emergencia de una hipótesis de trabajo, la pregunta problema y el objetivo general. Desde esta posibilidad, el proyecto de indagación es punto de llegada y no punto de partida. El objetivo de este artículo, estimado lector, es darte una ventaja en el proceso metodológico. No es evitarte el trabajo de lectura. Por el contrario. Es una incitación para trabajar con profundidad y dedicación una línea argumentativa que aquí se esboza sucintamente con algunas citas textuales. Esta es una provocación para que tu inicies tu propio trabajo de lectura.
Violencia basada en género en relaciones de pareja adolescentes: una revisión integral
Authors: Rincón Méndez Rosa Lisette
Published: February 2024

Este artículo de revisión hace parte del proyecto de tesis doctoral “Fenómeno de las violencias basadas en género en parejas de adolescentes escolarizados: un análisis crítico y reflexivo”. El diseño de la investigación es de corte cualitativo-interpretativo con fuentes documentales. Su propósito es indagar cómo se está abordando la violencia basada en género en las relaciones de pareja adolescentes en los diferentes estudios revisados. Esta búsqueda permitió identificar los escenarios relacionados con las violencias basada en género, que se reflejan en la interacción y en la socialización de los adolescentes escolarizados, entre los años 2015 y 2020, para lo cual se seleccionaron 50 documentos. Los resultados exponen la manifestación de diversas conductas y acciones de violencias basadas en género, para ello, se analizaron tres tendencias centrales: Inicialmente los estudios que tienen que ver con las manifestaciones de la violencia en las relaciones de pareja adolescentes; Posteriormente aquellos que se centran en los factores de riesgo de sufrir o ejercer violencia en la relación de pareja y finalmente, cómo emerge la violencia en las relaciones adolescentes. En conclusión, una de las características es un fuerte componente bidireccional, el factor erótico y condiciones culturales son términos que generan un espacio fecundo para explorar e investigar sobre la existencia de violencia basada en género en relaciones adolescentes y conocer si los patrones de comportamiento estereotipados han sido interiorizados o no entre los adolescentes.
Reflexiones académicas e investigativas. A propósito del nuevo lanzamiento de la revista
Authors: Muriel Alexander
Published: February 2024

Para la Universidad de San Buenaventura Cali y, en particular, para el equipo de la Revista Ciencias Humanas, es muy grato presentar a la comunidad nacional e internacional este nue-vo número que, con renovado vigor, vuelve a desplegar sus páginas para testimoniar las in-quietudes académicas y culturales, la exploración intelectual y el pensamiento científico de investigadores, docentes y estudiantes que quieran publicar con nosotros. Esta publicación, de carácter periódico y de repercusión latinoamericana, tiene ya una recono-cida trayectoria en los ámbitos de las ciencias humanas y sociales como revista de divulgación académica, situación que ofrece un apropiado panorama de visibilidad y comunicación.
El mundo contemporáneo como desafío para una filosofía o un pensar intercultural
Authors: Guadarrama González Pablo Manuel
Published: February 2024

Se cuestiona que una sola filosofía pueda afrontar el desafío de proponer alternativas de solución a numerosos temas que amenazan al mundo contemporáneo. Ante ello se analizan cuatro posibilidades de cultivar la filosofía: como ejercicio aséptico desvinculado de su contexto histórico; como reducción a su función hermenéutica; como interpretación, limitada al inmediatismo pragmático o como un intento racional de mejor comprensión de la realidad para contribuir a su transformación. A partir de tales actitudes, se sugiere la última como la más apropiada si se considera que una familia de corrientes filosóficas, entre las que se encuentra la filosofía intercultural, puede articularse de manera consensuada para lograr una mejor comprensión de los temas urgentes que agobian a la humanidad en la actualidad.
What ASEAN Must Learn from Timor-Leste: A Tripartite Analysis on Australian Foreign Policy Related to Timor Sea Treaty 2018
Authors: Kusumawardhana Indra , Saptarani Dewi Gustin
Published: February 2024

The Timor Gap had been a hotspot of territorial dispute between Australia and Timor-Leste. In 2018, Australia finally agreed to settle a permanent maritime boundary in favour of Timor-Leste. Why was Australia willing to sacrifice the border and give a favourable outcome to Timor-Leste? The research examined the importance of the tripartite approach to Foreign Policy analysis to understand why a country may choose seemingly unfavourable options in territorial disputes. The analysis showed how Australian foreign policy was influenced by agency-structure interactions within the international system. The research demonstrated that structural constraints at the international level influenced Australia’s decision, including the South China Sea dispute between ASEAN members and China, previous agreements Australia-Timor-Leste on the management of the Timor Gap, and domestic political dynamics in Australia. The research reveals a relationship between actors’ structural and dispositional dimensions in foreign policy. In the case of Australia, there is a strong link between democratic values ​​and respect for the international rules-based order. Altogether, this situation prompted Australia to continue negotiations with Timor-Leste over the Timor Gap and ultimately to accept an agreement for maritime delimitation in Timor-Leste’s favor.
Southeast Asian Regionalism: An Examination of the Progress and Priorities of ASEAN through its Joint Communiqués
Authors: Velasco Joseph Ching
Published: February 2024

In pursuit of ASEAN’s objective to formalize the ASEAN Community, this article critically examines the community-building progress and the organization’s key priorities. The research is guided by two research problems. First, what are the subjects discussed in each ASEAN community pillar? Second, how are the key issues addressed in relation to each ASEAN community pillar? A thematic analysis of the joint communiqués published by ASEAN from 2004-2019 was conducted to respond to these questions. More specifically, each communiqué was tagged and analyzed, and themes were subsequently derived, enabling a comprehensive examination of each area of the ASEAN community. The article contributes significant insights into the evolving landscape of ASEAN’s cooperation and integration. The findings elucidate on the shifting dynamics and complexities that shape ASEAN’s political-security, economic, and socio-cultural communities, shedding light on the organization’s changing priorities and challenges. The ASEAN Economic Community (AEC) prioritizes key growth areas, such as tourism, Small and Medium Enterprises (SMEs), and energy. For the ASEAN political-security, its focus is on ascertaining continued peace in the region as exemplified by collaboration on non-traditional security issues. Meanwhile, the ASEAN socio-cultural community primarily centers on environmental issues, disaster response and management, and the youth. However, the advancement of the ASEAN community has faced setbacks caused by the COVID-19 pandemic and the 2021 Myanmar coup d’état. Overall, the joint communiqués manifests the different initiatives that ASEAN has taken to deepen integration and a sense of community.
China and Regional Security in South and Southeast Asia: A Comparative Analysis of ASEAN and SAARC
Authors: Bettani Salman Ali , Ahmed Zahid Shahab
Published: February 2024

Asian regionalism is largely represented by economic cooperation at sub-regional levels, and the Association of Southeast Asian Nations (ASEAN) is seen as a prominent example of that. In contrast, the South Asian Association for Regional Cooperation (SAARC) has failed to take off as a platform for economic cooperation and has been hostage to the India-Pakistan rivalry. While ASEAN was established as a forum to address members’ security apprehensions concerning China, SAARC was created to focus on regional cooperation in non-controversial matters like trade and human security. Hence, ASEAN has engaged more deeply with China through various mechanisms. Conversely, SAARC-China relations remain limited because India, the most dominant actor in the organization and the region, views China as a threat to its security and hegemony in South Asia. The research, therefore, aims to answer the following question: How does one region successfully manage security challenges/threats while the other remains ensnared by them? Resolving this puzzle necessitates a nuanced understanding of the role of regionalism in Southeast Asia, emphasizing the significance of comprehending the process and evolution of regionalism in this context. To address this inquiry, the research employs a comparative-historical analysis grounded in archival data encompassing both primary and secondary sources. The investigation reveals that SAARC’s limited engagement with China is a consequence of India’s opposition, a dynamic absent in ASEAN, where Indonesia actively supports cooperation with China. The research underscores the critical importance of unraveling the complexities of regionalism in Southeast Asia to grasp the underlying factors contributing to divergent outcomes in these regional organizations.
New Thoughts on Formation of Tourism Perceived Images: An Investigation of Guangxi’s Overseas Chinese Students from ASEAN
Authors: Luo Tianyang , Mohamed Ahmad Edwin , Yusof Noor Suhaila
Published: February 2024

The research attempts to explain the psychological formation of the image of the sojourn by overseas students who are culturally homogeneous with the sojourn by constructing a comprehensive framework for the composition of the perceived image that contains the new dimension of cultural attachment. In particular, a group of 482 overseas Chinese students from ASEAN with learning experience in Guangxi are the respondents, benefiting from the deep ties between their ethnic and cultural backgrounds with mainland China. It is a strategic consideration based on Guangxi’s international tourism market and image promotion for ASEAN. The research uses quantitative analysis to combine the external influences previously supported in the literature, cultural attachment, and Cognitive-Affective-Conative (CAC) three-dimensional perceived image framework into a more comprehensive model to conduct a hypothetical-deductive study. The results of the quantitative analysis consolidate to a certain extent that the internal constitutive conditions of perceived image are promoted by the CAC model and further test the influence of perceived image under the combined effect of internal and external factors. Meanwhile, it is confirmed that cultural attachment has a strong role in the formation of the perceived image of a specific tourist group. The overall conclusions of the research are rich in academic significance and represent a theoretical expansion of the destination marketing system in response to real-world needs.
ADRIATICO – DIALOGHI INTERCULTURALI E INTRECCI DI LINGUE
Authors: Vučenović Nataša D.
Published: February 2024

Preface
FREEDOM, THE IDEA OF FATHERLAND AND NATIONAL INDEPENDENCE. THE IMAGE OF SOUTHERN SLAVIC PEOPLES IN THE WRITINGS OF GIUSEPPE MAZZINI
Authors: Baselica Giulia
Published: February 2024

Between the end of the 1830s and the beginning of the 1860s, the condition of the Southern Slavs was thoroughly analysed by Giuseppe Mazzini, who strongly believed in a necessary and close connection between the aspiration for unity and independence of peoples subject to foreign domination and the founding principle of nationality. Mazzini's ideas, which originated from his general pro-European vision and, in particular, from his specific interest in the history and expression of the individual Southern Slavic cultures, focused, especially in the 1850s, on the role of the Russian Empire. This paper aims to compare, as far as the Southern Slavic question is concerned, Mazzini's political vision, with reference to his writings, in particular the "Slavic Letters" with the debate animated by Russian Panslavism through the writings by contemporary Russian historians, such as Aleksandr Pypin and Michail Pogodin.
SOCIAL NETWORKS AS A LANGUAGE TEACHING TOOL
Authors: Marinković Milica M.
Published: February 2024

Social networks constitute an intrinsic part of our lives, not only in private aspects, but also professional and academic ones. Digitalisation in various professional and scientific fields, web 2.0, universal mobility and the growing use of multimedia tools in the classroom have led to the use of social networks as teaching material and tools.

In this work, the main social networks suitable for language teaching will be illustrated and various possibilities for their use will be indicated to derive maximum benefit from them in the classroom or during the student's independent study. Activities that may include the use of digital applications and the ways in which these platforms can be inserted into the different phases of the lesson will be indicated.

Finally, various practical examples of the inclusion of social networks in the classroom will be given, accompanied by intentional reflections to encourage language teachers to include web 2.0 tools among their working methods.