bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Approach for Understanding International Hospital Bed Numbers and Application to Local Area Bed Demand and Capacity Planning
Authors: Jones Rodney P.
Published: August 2024

Three models/methods are given to understand the extreme international variation in available and occupied hospital bed numbers. These models/methods all rely on readily available data. In the first, occupied beds (rather than available beds) are used to measure the expressed demand for hospital beds. The expressed occupied bed demand for three countries was in the order Australia > England > USA. Next, the age-standardized mortality rate (ASMR) has dual functions. Less developed countries/regions have low access to healthcare, which results in high ASMR, or a negative slope between ASMR versus available/occupied beds. In the more developed countries, high ASMR can also be used to measure the ‘need’ for healthcare (including occupied beds), a positive slope among various social (wealth/lifestyle) groups, which will include Indigenous peoples. In England, a 100-unit increase in ASMR (European Standard population) leads to a 15.3–30.7 (feasible range) unit increase in occupied beds per 1000 deaths. Higher ASMR shows why the Australian states of the Northern Territory and Tasmania have an intrinsic higher bed demand. The USA has a high relative ASMR (for a developed/wealthy country) because healthcare is not universal in the widest sense. Lastly, a method for benchmarking the whole hospital’s average bed occupancy which enables them to run at optimum efficiency and safety. English hospitals operate at highly disruptive and unsafe levels of bed occupancy, manifesting as high ‘turn-away’. Turn-away implies bed unavailability for the next arriving patient. In the case of occupied beds, the slope of the relationship between occupied beds per 1000 deaths and deaths per 1000 population shows a power law function. Scatter around the trend line arising from year-to-year fluctuations in occupied beds per 1000 deaths, ASMR, deaths per 1000 population, changes in the number of persons hidden in the elective, outpatient and diagnostic waiting lists, and local area variation in births affecting maternity, neonatal, and pediatric bed demand. Additional variation will arise from differences in the level of local funding for social care, especially elderly care. The problems associated with crafting effective bed planning are illustrated using the English NHS as an example.
10-Eicosanol Alleviates Patulin-Induced Cell Cycle Arrest and Apoptosis by Activating AKT (Protein Kinase B) in Porcine Intestinal Epithelial Cells
Authors: Lee Chae Hyun , Shin Sangsu , Lee Sang In
Published: August 2024

Patulin (PAT) is a fungal toxin prevalent in apples and apple products and associated with several toxic effects, potentially harming multiple organs, including the kidneys, liver, and colon. However, the precise molecular mechanism through which PAT affects the intestines remains comprehensively unclear. Therefore, this study aims to investigate the molecular effects of PAT on the intestinal epithelium. Gene expression profiling was conducted, hypothesizing that PAT induces cell cycle arrest and apoptosis through the PI3K-Akt signaling pathway. Cell cycle analysis, along with Annexin-V and propidium iodide staining, confirmed that PAT induced G2/M phase arrest and apoptosis in IPEC-J2 cells. Additionally, PAT activated the expression of cell cycle-related genes (CDK1, CCNB1) and apoptosis-related genes (BCL6, CASP9). Treatment with SC79, an AKT activator, mitigated cell cycle arrest and apoptosis. To identify natural products that could mitigate the harmful effects of PAT in small intestinal epithelial cells in pigs, the high-throughput screening of a natural product library was conducted, revealing 10-Eicosanol as a promising candidate. In conclusion, our study demonstrates that 10-Eicosanol alleviates PAT-induced cell cycle arrest and apoptosis in IPEC-J2 cells by activating AKT.
Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Authors: Buzatu Roxana , Luca Magda Mihaela , Bumbu Bogdan Andrei
Published: August 2024

Recent research has highlighted potential benefits of vitamin C in managing periodontal diseases, yet systematic reviews to consolidate these findings are scarce. This study aims to evaluate the effectiveness of vitamin C supplementation in preventing and treating periodontal diseases and elucidate the biological mechanisms underlying these effects. We conducted a systematic review following PRISMA guidelines, searching three databases up to 13 April 2024, for studies from 2010 onward. Our selection criteria aimed to capture a wide range of studies regarding vitamin C’s impact on periodontal health. After rigorous screening, 16 studies were included in the final analysis. Meta-analysis techniques were employed to synthesize data and evaluate the association between vitamin C intake and periodontal disease outcomes. The meta-analysis included 17,853 participants from studies with diverse geographical and demographic settings. Notable findings indicated that higher vitamin C intake was associated with a reduction in periodontal disease risk, with a pooled odds ratio (OR) of 1.52 (95% CI: 1.49–1.55). The individual studies reported ORs ranging from 0.62 (95% CI: 0.38–0.94) indicating significant protective effects, to 1.66 (95% CI: 1.04–2.64), suggesting increased risks associated with inadequate vitamin C levels. The heterogeneity among the studies was high (I2 = 95.46%), reflecting variability in study design and population characteristics. This systematic review confirms that vitamin C supplementation has a beneficial effect on periodontal health. The significant variability across studies suggests that individual dietary needs and baseline vitamin C levels might influence the effectiveness of supplementation. These findings underscore the importance of personalized nutritional guidance as part of comprehensive periodontal care. Future research should focus on longitudinal studies to better understand the causal relationships and potential confounding factors affecting the link between vitamin C intake and periodontal health.
Hybrid Polystyrene–Plasmonic Systems as High Binding Density Biosensing Platforms
Authors: Darr Charles M. , Hasan Juiena , Mathai Cherian Joseph , Gangopadhyay Keshab , Gangopadhyay Shubhra , Bok Sangho
Published: August 2024

Sensitive, accurate, and early detection of biomarkers is essential for prompt response to medical decisions for saving lives. Some infectious diseases are deadly even in small quantities and require early detection for patients and public health. The scarcity of these biomarkers necessitates signal amplification before diagnosis. Recently, we demonstrated single-molecule-level detection of tuberculosis biomarker, lipoarabinomannan, from patient urine using silver plasmonic gratings with thin plasma-activated alumina. While powerful, biomarker binding density was limited by the surface density of plasma-activated carbonyl groups, that degraded quickly, resulting in immediate use requirement after plasma activation. Therefore, development of stable high density binding surfaces such as high binding polystyrene is essential to improving shelf-life, reducing binding protocol complexity, and expanding to a wider range of applications. However, any layers topping the plasmonic grating must be ultra-thin (<10 nm) for the plasmonic enhancement of adjacent signals. Furthermore, fabricating thin polystyrene layers over alumina is nontrivial because of poor adhesion between polystyrene and alumina. Herein, we present the development of a stable, ultra-thin polystyrene layer on the gratings, which demonstrated 63.8 times brighter fluorescence compared to commercial polystyrene wellplates. Spike protein was examined for COVID-19 demonstrating the single-molecule counting capability of the hybrid polystyrene-plasmonic gratings.
Involvement of Expression of miR33-5p and ABCA1 in Human Peripheral Blood Mononuclear Cells in Coronary Artery Disease
Authors: Torres-Paz Yazmín Estela , Gamboa Ricardo , Fuentevilla-Álvarez Giovanny , Cardoso-Saldaña Guillermo , Martínez-Alvarado Rocío , Soto María Elena , Huesca-Gómez Claudia
Published: August 2024

MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression post-transcriptionally and are crucial in lipid metabolism. ATP-binding cassette transporter A1 (ABCA1) is essential for cholesterol efflux from cells to high-density lipoprotein (HDL). Dysregulation of miRs targeting ABCA1 can affect cholesterol homeostasis and contribute to coronary artery disease (CAD). This study aimed to investigate the expression of miRs targeting ABCA1 in human monocytes, their role in cholesterol efflux, and their relationship with CAD. We included 50 control and 50 CAD patients. RT-qPCR examined the expression of miR-33a-5p, miR-26a-5p, and miR-144-3p in monocytes. Logistic regression analysis explored the association between these miRs and CAD. HDL’s cholesterol acceptance was analyzed using the J774A.1 cell line. Results showed that miR-26a-5p (p = 0.027) and ABCA1 (p = 0.003) expression levels were higher in CAD patients, while miR-33a-5p (p < 0.001) levels were lower. Downregulation of miR-33a-5p and upregulation of ABCA1 were linked to a lower CAD risk. Atorvastatin upregulated ABCA1 mRNA, and metformin downregulated miR-26a-5p in CAD patients. Decreased cholesterol efflux correlated with higher CAD risk and inversely with miRs in controls. Reduced miR-33a-5p expression and increased ABCA1 expression are associated with decreased CAD risk. miR deregulation in monocytes may influence atherosclerotic plaque formation by regulating cholesterol efflux. Atorvastatin and metformin could offer protective effects by modulating miR-33a-5p, miR-26a-5p, and ABCA1, suggesting potential therapeutic strategies for CAD prognosis and treatment.
Hydrogen Bond Strengthens Acceptor Group: The Curious Case of the C–H···O=C Bond
Authors: Basu Kingshuk , Brielle Esther S. , Arkin Isaiah T.
Published: August 2024

An H-bond involves the sharing of a hydrogen atom between an electronegative atom to which it is covalently bound (the donor) and another electronegative atom serving as an acceptor. Such bonds represent a critically important geometrical force in biological macromolecules and, as such, have been characterized extensively. H-bond formation invariably leads to a weakening within the acceptor moiety due to the pulling exerted by the donor hydrogen. This phenomenon can be compared to a spring connecting two masses; pulling one mass stretches the spring, similarly affecting the bond between the two masses. Herein, we describe the opposite phenomenon when investigating the energetics of the C–H···O=C bond. This bond underpins the most prevalent protein transmembrane dimerization motif (GxxxG) in which a glycine Cα-H on one helix forms a hydrogen bond with a carbonyl in a nearby helix. We use isotope-edited FT-IR spectroscopy and corroborating computational approaches to demonstrate a surprising strengthening of the acceptor C=O bond upon binding with the glycine Cα-H. We show that electronic factors associated with the Cα-H bond strengthen the C=O oscillator by increasing the s-character of the σ-bond, lowering the hyperconjugative disruption of the π-bond. In addition, a reduction of the acceptor C=O bond’s polarity is observed upon the formation of the C–H···O=C bond. Our findings challenge the conventional understanding of H-bond dynamics and provide new insights into the structural stability of inter-helical protein interactions.
In Vivo Luciferin–Luciferase Reaction in Micro-Mini Pigs Using Xenogeneic Rat Bone Marrow Transplantation
Authors: Abe Tomoyuki , Endo Kazuhiro , Hanazono Yutaka , Kobayashi Eiji
Published: August 2024

Luminescent technology based on the luciferin–luciferase reaction has been extensively employed across various disciplines as a quantitative imaging modality. Owing to its non-invasive imaging capacity, it has evolved as a valuable in vivo bioimaging tool, particularly in small animal models in fields such as gene and cell therapies. We have previously successfully generated rats with a systemic expression of the luciferase gene at the Rosa26 locus. In this study, we transplanted bone marrow from these rats into micro-mini pigs and used in vivo imaging to non-invasively analyze the dynamics of the transplanted cells. In addition, we established that the rat-to-pig transplantation system is a discordant system, similar to the pig-to-human transplantation system. Thus, rat-to-pig transplantation may provide a clinically appropriate large animal model for pig-to-human xenotransplantation.
Biochar/Biopolymer Composites for Potential In Situ Groundwater Remediation
Authors: Petrangeli Papini Marco , Cerra Sara , Feriaud Damiano , Pettiti Ida , Lorini Laura , Fratoddi Ilaria
Published: August 2024

This study explores the use of pine wood biochar (BC) waste gasified at 950 °C as fillers in polymer matrices to create BC@biopolymer composites with perspectives in groundwater remediation. Four biochar samples underwent different sieving and grinding processes and were extensively characterized via UV–Vis, FTIR, and FESEM–EDS, highlighting the fact that that BCs are essentially graphitic in nature with a sponge-like morphology. The grinding process influences the particle size, reducing the specific surface area by about 30% (evaluated by BET). The adsorption performances of raw BC were validated via an adsorption isotherm using trichloroethylene (TCE) as a model contaminant. A selected BC sample was used to produce hydrophilic, stable polymer composites with chitosan (CS), alginate (ALG), potato starch (PST), and sodium carboxymethylcellulose (CMC) via a simple blending approach. Pilot sedimentation tests over 7 days in water identified BC@PST and BC@CMC as the most stable suspensions due to a combination of both hydrogen bonds and physical entrapment, as studied by FTIR. BC@CMC showed optimal distribution and retention properties without clogging in breakthrough tests. The study concludes that biopolymer-based biochar composites with improved stability in aqueous environments hold significant promise for addressing various groundwater pollution challenges.
In-Depth Study on the Application of a Graphene Platelet-reinforced Composite to Wind Turbine Blades
Authors: Kim Hyeong Jin , Cho Jin-Rae
Published: August 2024

Graphene platelets (GPLs) are gaining popularity across various sectors for enhancing the strength and reducing the weight of structures, thanks to their outstanding mechanical characteristics and low manufacturing cost. Among many engineering structures, wind turbine blades are a prime candidate for the integration of such advanced nanofillers, offering potential improvements in the efficiency of energy generation and reductions in the construction costs of support structures. This study aims to explore the potential of GPLs for use in wind turbine blades by evaluating their impact on material costs as well as mechanical performance. A series of finite element analyses (FEAs) were conducted to examine the variations of mechanical performances—specifically, free vibration, bending, torsional deformation, and weight reductions relative to conventional fiberglass-based blades. Details of computational modeling techniques are presented in this paper. Based on the outcomes of these analyses, the mechanical performances of GPL-reinforced wind turbine blades are reviewed along with a cost–benefit analysis, exemplified through a 5MW-class wind turbine blade. The findings affirm the practicality and benefits of employing GPLs in the design and fabrication of wind turbine blades.
Molecular Dynamics Study on Wear Resistance of High Entropy Alloy Coatings Considering the Effect of Temperature
Authors: Zhang Xianhe , Yang Zhenrong , Deng Yong
Published: August 2024

High entropy alloys have excellent wear resistance, so they have great application prospects in the fields of wear resistance and surface protection. In this study, the wear resistance of the FeNiCrCoCu high entropy alloy coating was systematically analyzed by the molecular dynamics method. FeNiCrCoCu high entropy alloy was used as a coating material to adhere to the surface of a Cu matrix. The friction and nanoindentation simulation of this coating material were carried out by controlling the ambient temperature. The influence of temperature on its friction properties was analyzed on five aspects: lattice structure, dislocation evolution, friction coefficient, hardness, and elastic modulus. The results show that with the increase of temperature, the disorder of the lattice structure increases, which leads to an increase of the tangential force and friction coefficient in the friction process. At 300 K and 600 K, the ordered lattice structure of the high entropy alloy coating material is basically the same, and thus its hardness is basically the same. However, the dislocation density at 600 K is significantly reduced compared with that at 300 K, resulting in an increase of the elastic modulus of the material from 173 GPa to 219 GPa. At temperatures of 900 K and 1200 K, lattice disorder takes place rapidly, and dislocation density also decreases significantly, resulting in a significant decrease in the hardness and elastic modulus of the material. When the temperature reaches 900 K, the wear resistance of the FeNiCrCoCu high entropy alloy coating decreases sharply. This work is of great value in the analysis of wear resistance of high entropy alloys at high temperature.
Modeling and Experimental Study of Vibration Energy Harvester with Triple-Frequency-Up Voltage Output by Vibration Mode Switching
Authors: Xu Jiawen , Liu Zhikang , Dai Wenxing , Zhang Ru , Ge Jianjun
Published: August 2024

Conventional wireless sensors rely on chemical batteries. Replacing or charging their batteries is tedious and costly in some situations. As usable kinetic energy exists in the environment, harvesting vibration energy and converting it into electrical energy has become a hotspot. However, the power output capability of a conventional piezoelectric energy harvester (PEH) is limited by its low operational frequency. This paper presents a new mechanism for achieving continuous triple-frequency-up voltage output in a PEH. The proposed system consists of a slender piezoelectric cantilever with two short cantilever-based stoppers. The piezoelectric cantilever undergoes a pure bending mode without contacting the stoppers. In addition, the beam switches into a new vibration mode by contacting the stoppers. The vibration modes switching yields reverses the signs of voltage outputs, inducing triple-frequency-up voltage output. Analytical and experimental investigations are presented, and it is shown that a significant triple-frequency up-conversion of the voltage output can be obtained over a wide frequency range. A peak power output of 3.03 mW was obtained. The proposed energy harvester can support a wireless sensor node.
Assessment of the Efficacy of the Antihistamine Drug Rupatadine Used Alone or in Combination against Mycobacteria
Authors: Tian Xirong , Ma Wanli , Yusuf Buhari , Su Biyi , Hu Jinxing , Zhang Tianyu
Published: August 2024

The emergence of drug-resistant mycobacteria has rendered many clinical drugs and regimens ineffective, imposing significant economic and healthcare burden on individuals and society. Repurposing drugs intended for treating other diseases is a time-saving, cost-effective, and efficient approach for identifying excellent antimycobacterial candidates or lead compounds. This study is the first to demonstrate that rupatadine (RTD), a drug used to treat allergic rhinitis, possesses excellent activity against mycobacteria without detectable resistance, particularly Mycobacterium tuberculosis and Mycobacterium marinum, with a minimal inhibitory concentration as low as 3.13 µg/mL. Furthermore, RTD exhibited moderate activity against nonreplicating M. tuberculosis with minimal inhibitory concentrations lower than drugs targeting the cell wall, suggesting that RTD has great potential to be modified and used for the treatment of nonreplicating M. tuberculosis. Additionally, RTD exhibits partial synergistic effects when combined with clofazimine, pretomanid, and TB47 against M. tuberculosis, providing the theoretical foundation for the development of treatment regimens. Transcriptomic profiling leads us to speculate that eight essential genes may be the targets of RTD or may be closely associated with mycobacterial resistance to RTD. In summary, RTD may be a promising hit for further antimycobacterial drug or regimen optimization, especially in the case of nonreplicating mycobacteria.
Research on Infrared Dim Target Detection Based on Improved YOLOv8
Authors: Liu Yangfan , Li Ning , Cao Lihua , Zhang Yunfeng , Ni Xu , Han Xiyu , Dai Deen
Published: August 2024

Addressing the formidable challenges in spatial infrared dim target detection, this paper introduces an advanced detection approach based on the refinement of the YOLOv8 algorithm. In contrast to the conventional YOLOv8, our method achieves remarkable improvements in detection accuracy through several novel strategies. Notably, by incorporating a deformable convolutional module into the YOLOv8 backbone network, our method effectively captures more intricate image features, laying a solid foundation for subsequent feature fusion and detection head predictions. Furthermore, a dedicated small target detection layer, built upon the original model, significantly enhances the model’s capability in recognizing infrared small targets, thereby boosting overall detection performance. Additionally, we utilize the WIoU-v3 as the localization regression loss function, effectively reducing sensitivity to positional errors and leveraging the advantages of multi-attention mechanisms. To enrich the quantity and quality of the spatial infrared dim target dataset, we employ image enhancement techniques to augment the original dataset. Extensive experiments demonstrate the exceptional performance of our method. Specifically, our approach achieves a precision of 95.6%, a recall rate of 94.7%, and a mean average precision (mAP) exceeding 97.4%, representing substantial improvements over the traditional YOLOv8 algorithm. Moreover, our detection speed reaches 59 frames/s, satisfying the requirements for real-time detection. This achievement not only validates the efficacy and superiority of our algorithm in spatial infrared dim target detection, but also offers novel insights and methodologies for research and applications in related fields, holding immense potential for future applications.
Hydrochemical Evolution Process and Mechanism of Groundwater in the Hutuo River Alluvial Fan, North China
Authors: Gai Junbai , Yan Baizhong , Fan Chengbo , Tuo Yapeng , Ma Miaomiao
Published: August 2024

Due to extensive groundwater exploitation, a groundwater funnel has persisted in the Hutuo River alluvial fan in Shijiazhuang since the 1980s, lasting nearly 40 years and significantly impacting the groundwater chemical characteristics. In this study, based on the groundwater level and chemistry data, the hydrochemical evolution processes and mechanisms of the groundwater during the 1980 groundwater funnel period and the post-2015 artificial governance period were investigated using traditional hydrogeochemical methods and inverse hydrogeochemical simulations. The results show the following: (1) The ion concentrations gradually increased along the groundwater flow path, where they displayed a pattern of lower levels in the northwest and higher levels in the southeast. From 1980 to 2021, the concentrations of major ions were increased. (2) In 1980s, the groundwater hydrochemical type predominantly exhibited HCO3—Ca. From 1980 to 2015, the hydrochemical types diversified into HCO3·Cl—Ca, HCO3—Ca·Mg, and HCO3·SO4—Ca types. Following the artificial governance, the groundwater level rise led to an increase in the concentrations of SO42− and Mg2+. Post-2015, the prevailing hydrochemical type changed to HCO3·SO4—Ca·Mg. (3) The changes in the groundwater level and ion concentrations were quantitatively strongly correlated and exhibited spatial similarity. (4) In the 1980s, the groundwater hydrochemical composition was primarily controlled by the dissolution of albite, dolomite, halite, and quartz; reverse cation exchange; and groundwater exploitation. Since 2015, the hydrochemical composition has mainly been influenced by the dissolution of albite, calcite, and quartz; positive cation exchange; river–groundwater mixing; and industrial activities, with increasing intensities of both water–rock interactions and human activities.
Unsteady Flow of Casson Fluid between Two Side Walls over an Infinite Plate
Authors: Ali Munsif
Published: August 2024

In the present study, the velocity field corresponding to the unsteady flow of Casson fluid between two parallel side walls perpendicular to an infinite plate that exerts an oscillating shear stress to the fluid is determined with the help of Fourier sine and cosine transforms. Exact solutions are obtained and given in simple form as a combination of transient and steady-state solutions, which satisfy the governing equation and all imposed initial and boundary conditions. These solutions are reduced to the similar solutions corresponding to the motion over an infinite plate, when and Newtonian fluid by making Casson parameter Furthermore, effect of side walls on the motion of fluid, the time which is required to attain the steady state and the distance between the side walls for which their presence can be ignored are graphically determined.
Efficient quadrature rules for numerical evaluation of singular and hyper singular integrals
Authors: Ahmad Shafiq , Islam Siraj ul
Published: August 2024

In this paper Newton-Cote type quadrature rule, Haar wavelets, and hybrid functions-based quadratures are used for the numerical solution of singular and hyper singular integrals having singularity at the origin. These integrals include the Cauchy principle value (CPV) and Hadamard finite part (HFP) integrals. The proposed rules are tested numerically on some test problems to check the efficiency and accuracy of the new methods.
Thin film Maxwell-Power Law Fluid Flow on an extending surface
Authors: Gul Taza , Khan Zaitoon
Published: August 2024

In this research article, the examination is done on film flow of two-dimensional fluid along with transfer of heat in a magnetic field on an unsteady extending sheet. To gain the appropriate outputs for the flow efficiency and rate of transfer of heat, the Power law fluids are mixed with the viscoelastic fluids which reduce the viscosity of the fluids. The heat transfer rate is further improved with the inclusion of nanoparticles. The flow and heat transmission characteristics of a Maxwell, Power-law-model-fluid along with Joule absorption and changeable liquid sheet thickness are examined. The combined model of the two non-Newtonian fluids also incorporated the nanofluid's influence. To create the coupled comparable ordinary differential equations (ODEs) that the homotopy analytical method (HAM) along with appropriate similarity transformations are used. Impacts of variations of different significant factors like and number of fluid flow of fluid film with the transfer of heat are perceived. The influence of the unsteadiness factor on a thin film is discovered analytically for various estimations. Despite this, the implanted factors utilized for understanding the physical demonstration, like magnetic factor , inertial parameter , Eckert number , penetrability factor , Prandtl number Pr and Deborah number have been offered by graphs and deliberated in detail.
Espacios académicos en la educación virtual y el logro de competencia en los estudiantes universitarios
Authors: Ticona-Arapa Haydee Clady , Zela Payi Nelly Olga , Apaza Tarqui Alejandro
Published: August 2024

Las exigencias del mundo actual requieren profesionales competentes, para el logro de esta demanda, es necesario contar con espacios académicos con un confort adecuado; el estudio tuvo como objetivo determinar la relación entre espacio académico en la educación virtual y el logro de competencias de los estudiantes del Programa de Estudios de Educación Inicial. Esta investigación está bajo el enfoque cuantitativo no experimental de diseño correlacional. La población estuvo conformada por 350 estudiantes del Programa, con una muestra aleatoria simple de 150 estudiantes. Se utilizó el instrumento virtual formulario Google y se realizó entrevistas a profundidad. Los instrumentos aplicados fueron el cuestionario con preguntas cerradas y una ficha de observación. Los resultados de la investigación determinaron que, si existe una correlación positiva elevada, llegando a concluir que, a mejores espacios académicos en educación virtual, mejores serán las competencias desarrolladas por los estudiantes en tiempos de pandemia.
Gestión y conciencia ambiental en docentes de instituciones públicas
Authors: Santamaria Vicente Helí Yonel , Nuñez Vara Fernando , Tamayo Huamán Pedro , Trujillo Medrano Betty , Boza Martel Cesy Ivonne
Published: August 2024

La investigación examina la relación entre la gestión ambiental y la conciencia ambiental en docentes de instituciones públicas. El objetivo fue establecer cómo estos dos conceptos están interrelacionados en este grupo específico. Se empleó una metodología básica, con un enfoque descriptivo, y se utilizó el método hipotético-deductivo con un diseño no experimental, transversal y correlacional. La muestra consistió en 100 docentes seleccionados mediante muestreo no probabilístico, de una población total de 1503 docentes. La confiabilidad del cuestionario de gestión ambiental fue de .947 y del cuestionario de conciencia ambiental fue de .829, ambas medidas mediante Alfa de Cronbach. Los resultados indicaron una relación directa y significativa entre la gestión ambiental y la conciencia ambiental, con un coeficiente Rho de Spearman de 0.748 y un valor p < 0.05. Además, se encontró una correlación significativa con las dimensiones cognitiva, afectiva, conativa y activa de la conciencia ambiental, también con p < 0.05. Se concluye que mejorar la gestión ambiental en instituciones públicas puede fortalecer la conciencia ambiental de los docentes, contribuyendo a una mayor preservación de los recursos del planeta y una educación ambiental más efectiva.
Effect of endogenic and exogenic oxidative stress changes during spontaneous preterm birth
Authors:   Obstetrics and Gynaecology Clinic, UMHAT ", Koleva-Korkelia I. М. ,   Prof. St. Kirkovich",   6000, Stara Zagora, Bulgaria, Jasem R. J. ,   Obstetrics and Gynaecology Clinic, UMHAT "Prof. St. Kirkovich" 6000, Stara Zagora, Bulgaria, Kostadinova D. S. ,   Obstetrics and Gynaecology Clinic, UMHAT "Prof. St. Kirkovich" 6000, Stara Zagora, Bulgaria, Angelova M. ,   Obstetrics and Gynaecology Clinic, UMHAT "Prof. St. Kirkovich" 6000, Stara Zagora, Bulgaria, Petkova-Parlapanska K. ,   Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria, Georgieva E. D. ,   Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria, Nikolova G. D. ,   Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria, Karamalakova Y. D. ,   Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria
Published: August 2024

This study aimed to assess the effect of endogenic and exogenic oxidative stress (OS) changes in the maternal response and establish the relationship to plasma non-infectious OS-associated inflammation in spontaneous preterm birth (SPTB), (in declared active labor with an intact amniotic sac and no recorded inflammation) beginning at 32–34+6 gestational weeks. Results were compared with women who gave birth at term (TB) in the active phase. To assess changes in OS, the reactive oxygen-nitrogen (RONS) species, as nitric oxide (•NO), superoxide (•O2‾) radicals, albumin SHmalformation (5-MSL), and ROS peroxidation were investigated by electron paramagnetic resonance (X-band-EPREmxmicro spectrometer, Bruker) spectroscopy. The antioxidant enzymes (GSH, GPs1, and TAC) were evaluated by ELISA kits. The present study shows significant associations between the endogenic and exogenic non-infectious OS elevation due to the RONS up-regulation and the secondary OS generation associated with a lack of antioxidant protection in SPTB.
RETURN ON ASSETS, DEBT TO EQUITY RATIO, TAX AVOIDANCE TERHADAP NILAI PERUSAHAAN
Authors: Febrica Jesisca , Lekok Widyawati
Published: August 2024

The purpose of this study is to provide empirical evidence about the factors that affect firm value in Indonesia. Those factors are return on assets, debt to equity ratio, current ratio, dividend payout ratio, tax avoidance, and firm size. This study uses a population of non-finance companies that are listed in Indonesia Stock Exchange in the year 2019-2021. The selection sample in this study research was based on purposive sampling technique with a total 237 data samples used. This study uses a multiple regression model. The results of this study indicate that the return on assets has a positive effect on firm value, the greater return on assets can indicate that management is doing a good job thereby increasing firm value. The results of the debt to equity ratio have a positive effect on firm value, a high debt to equity ratio reflects that the company has a long-term investment strategy so that investors will invest in the company so that it will increase the firm value. The results of tax avoidance have a positive effect on firm value, tax avoidance can indicate a manager's personal motivation to manipulate company profits and provide false information to investors so that less tax avoidance can increase firm value. Meanwhile, the current ratio, dividend payout ratio, and firm size have no effect on firm value.
FAKTOR-FAKTOR YANG MEMENGARUHI NILAI PERUSAHAAN NON KEUANGAN DI BURSA EFEK INDONESIA
Authors: Alfinjo Harris Wijaya , Vivianti Jenny
Published: August 2024

The purpose of this study is to obtain empirical evidence about the influence of variable current ratio, debt to equity ratio, return on assets, total assets turnover, return on equity, and firm size on firm value. The object sample of this research are non-financial companies listed in Indonesia Stock Exchange (IDX) period 2019 to 2021 using the purposive sampling method  and the sampling resulted in 204 companies with 612 data. This research analysis used multiple regression analysis method. The results of this study indicate that variable  return on assets, return on equity, and firm size have an effect on firm value. While variable current ratio, debt to equity ratio and total assets turnover have no effect on firm value.
FAKTOR-FAKTOR YANG MEMENGARUHI NILAI PERUSAHAAN NON KEUANGAN DI INDONESIA
Authors: Angelica Martha , Prajitno Sugiarto
Published: August 2024

This study aims to determine the effect of the dependent variable Firm Value on the independent variables’ Return On Assets, Debt to Asset Ratio, Current Assets, Firm Size, Dividend Payout Ratio, Sales Growth, and Tax Avoidance. The object of this study uses data from non-financial companies listed on the Indonesia Stock Exchange from 2019-2021 as the population. The sampling process used the purposive sampling method and the method for analyzing data used the multiple regression method. There were 79 companies, with 237 data that passed the criteria. This study states that Return On Assets, Debt to Asset Ratio, and Tax Avoidance has an effect on Firm Value but Current Ratio, Firm Size, Dividend Payout Ratio, and Sales Growth have no effect on Firm Value.
PENGARUH KINERJA LINGKUNGAN DAN FAKTOR LAINNYA TERHADAP NILAI PERUSAHAAN MANUFAKTUR DI INDONESIA
Authors: Wigiarni Kesdha Rizki , Chandra Santoso
Published: August 2024

The purpose of this study was to determine the effect of environmental performance, profitability, firm size, board of director on firm value. In addition, this study uses audit committee, institutional ownership and capital structure to determine the effect on firm value. The population of this study are manufacturing companies listed on Indonesia Stock Exchange during 2019 – 2021 period. The sampling technique use purposive sampling with the results of 35 companies which were tested using multiple linear regression. The following results from this study indicate that environmental performance, profitability, audit committee, institutional ownership and capital structure has no effect on firm value. While, company size and board of directors affect firm value because each of these variables can attract investors to invest.
PENGARUH TATA KELOLA PERUSAHAAN DAN FAKTOR LAINNYA TERHADAP INTEGRITAS LAPORAN KEUANGAN
Authors: Haryanto Dhisca , Mungniyati Mungniyati
Published: August 2024

By the end of 2022, there are 828 companies whose shares are officially listed and can be traded on the Indonesia Stock Exchange. Investors can find out the company's financial performance by analyzing the integrity of the financial statements. The purpose of this research is to obtain empirical evidence about the effect of institutional ownership, managerial ownership, audit committee, independent commissioner, industry-specialist accounting firm, audit tenure, leverage, and company size on the integrity of financial statements. The object of this research is energy, consumer cyclicals, and consumer non-cyclicals sector companies listed on the Indonesia Stock Exchange with the period from 2020 to 2022. This research used a sample of 612 data from 204 companies. The sample selection method used is purposive sampling and used multiple regression in conducting data analysis. The results of this research indicate that institutional ownership and audit committee have a negative effect on report integrity, leverage has a positive effect on the integrity of financial statements, while managerial ownership, independent commissioners, industry-specialist accounting firm, audit tenure, and company size have no effect on the integrity of financial statements.
Peran Brand Awareness, Perceived Value, dan Brand Uniqueness dalam meningkatkan Brand Loyalty pada Industri Fast Fashion
Authors: Ruslim Tommy Setiawan , Febrian Ferdy , Suryawan Ian Nurpatria
Published: August 2024

Fast fashion is a term used to describe a highly profitable business model based on imitating catwalk trends and high fashion designs, and mass-producing them at a low cost. One of the famous fast fashion brands in Indonesia is XYZ. But in the past few years, XYZ’s brand value has decreased. The purpose of this research is to examine whether 1) brand awareness can influence brand loyalty. 2) perceived value can influence brand loyalty. 3) brand uniqueness can influence brand loyalty. Purposive sampling method used by distributing online questionnaire with a sample of 208 respondents and then processed by using smartPLS- SEM. The result of this study indicate that brand awareness, perceived value, and brand uniqueness have a positive and significant influence towards brand loyalty.
Pengaruh Persistensi Laba, Solvabilitas, dan Variabel Lainnya terhadap Kualitas Laba
Authors: Danibrata Bagas
Published: August 2024

The purpose of this research is to obtain empirical evidence about whether earnings persistence, solvency, liquidity, profitability, audit committee, and commissioner independence as independent variables have an influence on earnings quality as the dependent variable. This research used 210 data from 42 companies operating in the cyclical and non cyclical sectors that listed on Indonesian Stock Exchange for the period 2015 to 2022. The research method used in this research is the purposive sampling method in selecting samples and used multiple regression for the data analysis. The result of this research shows that independent variables earnings persistence and profitability affect earnings quality. While other independent variables earnings persistence, liquidity, audit committee, and independent commissioner have no effect toward earnings quality.  Companies tend to do earnings management to keep their profit stable and to increase their profitability so which could end up lowering the quality of earnings
A Historical-Cognitive Linguistics Study of Caesar’s Characterization in Shakespearean Plays
Authors: Zhou Dr. Bin
Published: August 2024

By using “polysemy model” of semantic change theories in historical linguistics, “mapping” and “conceptual integration” of metaphor, and “classical taxonomic structure” of categorization theories in cognitive linguistics, and literary conventions of structuralist poetics in literary studies, this article studies Caesar’s characterization in Shakespeare’s Julius Caesar and other plays. After analyzing the semantic change of “Caesar” and different characters’ cognition on Caesar in the fictional world created by dialogues and character interactions, this article discovers that the negotiation and exchange between the totalculture in 1599 and Shakespeare’s personal artistic pursuit propel Shakespeare to create an ambiguous but great and unique Caesar in Julius Caesar, within the two kinds of intertexts consisting of different characters’ discourses scattered in other Shakespearean plays, Caesar’s ambiguity is eliminated, and his greatness and uniqueness are strengthened, and it is in his skillful maneuver of different literary conventions in characterizing Caesar that Shakespeare’s great literary competence is manifested.
Museum educational space for school: to the question of studying the course ’Basis of the religious cultures and social ethics’
Authors: Пустовойт Ю.В.
Published: August 2024

Музей и школа призваны создавать единое пространство актуализации духовно-нравственных ценностей. В статье приведен свод музеев России, имеющих потенциал стать социальными партнерами школы в преподавании предметов духовно-нравственного содержания и в экспозиции которых нашла отражение религиозная тематика. Перечислены возможные формы работы с предметами коллекций этих музеев на уроках модулей религиоведческого содержания учебного предмета Основы религиозной культуры и светской этики , в т.ч. обозначены перспективы применения электронных (мультимедийных) технологий.

The museum and the school are called upon to create a single space for the actualization of spiritual and moral values. The article provides a set of museums in Russia that have the potential to become social partners of the school in teaching subjects of spiritual and moral content and whose exposition is reflected in religious subjects. Possible forms of work with objects of collections of these museums are listed in the lessons of the modules of the religious studies of the subject Basis of the Religious Culture and Secular Ethics, prospects for the use of electronic (multimedia) echnologies are indicated.
Alpine cowbell
Authors: Филиппов Ю.В.
Published: August 2024

В статье рассматривается альпийский коровий колокольчик, предмет, хранящийся в фондах Нижегородского государственного историко архитектурного музея заповедника (НГИАМЗ). Определяется его происхождение, проводится анализ изображений на нем. Также рассматриваются краткая история места, откуда он происходит, и пути попадания в фонды музея.

The article deals with an alpine cow bell, an object stored in NGIAMZ funds. Its origin is determined, images on it are analyzed. The short history of the place where it comes from and ways of getting to the museum funds is also considered.
Research of the traces of the Russian expedition of the 17th century on the island of Thaddeus Severny and in the Gulf of Sims
Authors: Филин П.А.
Published: August 2024

В статье описаны новые исследования места гибели русской экспедиции XVII в. на острове Фаддея и на берегу залива Симса. Дана краткая история обнаружения уникального объекта археологического наследия и его изучения А.П.Окладниковым. Кратко дана характеристика находок, сделанных на территории объекта. Выдвинуты предложения по его новым исследованиям.

The article describes new studies of the site of the death of the Russian expedition of the 17th century on the island of Thaddeus and on the shore of Sims Bay. A brief history of the discovery of a unique object of archaeological heritage and its study by A.Okladnikov is given. A brief description of the findings made on the site is given. Proposals for its new research have been put forward.
Between traditions and virtual reality: coronavirus epidemic as a catalyst for cultural change
Authors: Плещенко В.И.
Published: August 2024

Эпидемия коронавируса нанесла тяжелый удар по индустрии культуры и отдыха по всему миру. Пытаясь приспособиться к условиям карантина, учреждения традиционной культуры и сферы развлечений запускают новые онлайн-продукты, потребляемые через сеть Интернет. Виртуальная культура имеет ряд преимуществ, обусловленных удобством и меньшей ценой для пользователей. Между тем виртуальная культура более подходит для «мозаичного сознания», не обеспечивает полноценных эффектов присутствия и причастности, в связи с чем возникают сомнения в ее способности обеспечить культурное воспроизводство в современном обществе.

The coronavirus epidemic was a severe blow to the global culture and recreation industry. In an attempt to adapt to the quarantine conditions, traditional culture and entertainment institutions are launching new online products consumed through the Internet. Virtual culture has a number of advantages due to convenience and lower cost to users. Meanwhile, virtual culture is more suitable for "mosaic consciousness", does not provide full-fledged effects of presence and involvement, and therefore doubts about its ability to ensure cultural reproduction in modern society.
Museum projects of Russian futurist artists
Authors: Петрова Д.А.
Published: August 2024

В статье рассматриваются музейные проекты русских футуристов. После революции художникам-футуристам была выражена поддержка, т.к. их творчество было созвучно новым задачам страны. Ориентация на настоящее и будущее выразилась в наибольшей степени в организации музея, который возглавили сами художники, предлагавшие собственные концепции развития искусства, столь же новаторские и радикальные, как и их творчество.

The article discusses museum projects of Russian futurists. After the revolution, support was expressed to the futurist artists their creativity was in tune with the new tasks of the country. The orientation towards the present and the future was expressed to the greatest extent in the organization of the museum, which was headed by the artists themselves, who proposed their own concepts for the development of art, as innovative and radical as their work.
Pottery in the Balakhna district of the Nizhny Novgorod province (Based on materials from the stock collection of the Nizhny Novgorod State Historical and Architectural Museum-Reserve)
Authors: Казарина Н.И.
Published: August 2024

В статье рассматривается проблема происхождения и развития гончарного производства в Балахнинском уезде Нижегородской губернии, предпринята попытка проследить раннюю традицию промысла и ее трансформацию на примере материалов фондовой коллекции керамики Нижегородского государственного историко-архитектурного музея-заповедника.

The article deals with the problem of origin and development of pottery production in Balakhna County, Nizhny Novgorod Province. An attempt is made to trace the early tradition of pottery and its transformation on the example of materials from the ceramics collection of the Nizhny Novgorod State Historical and Architectural Museum-Reserve.
Fishing hooks’ handicraft of Bezvodnoye village, Nizhny Novgorod region
Authors: Филиппов Ю.В.
Published: August 2024

В статье рассматривается один из кустарных промыслов села Безводное Нижегородской области. Это промысел по изготовлению рыболовных крючков. С помощью письменных и этнографических источников раскрываются приемы изготовления крючков и пути их реализации.

The article deals with one of the handicrafts of Bezvodnoye village in Nizhny Novgorod region. It is a craft for making fishing hooks. With the help of written and ethnographic sources the methods of making hooks and ways of their realization are revealed.