bluuebunny/crossref_metadata_2025 huggingface dataset:
Antioxidant Activity of Avocado Folium (Persea americana M.)
Authors: Wusurwut Fahriya , Hasnaeni Hasnaeni , Waris Risda
Published: January 2025

Free radicals can be formed through normal cell metabolism events, malnutrition and as a result of responses to external influences such as pollution and ultraviolet rays. Free radicals can cause premature aging, therefore antioxidants are needed to prevent premature aging. Avocado folium (Persea americana M.) contain secondary metabolite compounds, namely alkaloids, saponins, tannins, glycosides and flavonoids in the form of quercetin, where flavonoid compounds can act as antioxidants. This study aims to determine the antioxidant activity of avocado leaf extract (P. americana M), using the (2,2-dihphenyl-1-picrylhdrazil) (DPPH)  method. The sample used in this research was avocado folium obtained from Southeast Maluku, Maluku Province). DPPH method with a UV-Vis spectrophotometer at a wavelength of 514 nm. The antioxidant activity of ethanol extract of avocado folium in this test is 112.410 µg / mL. The results of this study show that avocado folium extract has moderate antioxidant activity.
Profile and Characteristics of Analgesic Use in Myalgia Cases at Soromandi Health Center
Authors: Rahmatillah Rahmatillah
Published: January 2025

Myalgia is a common muscle pain condition that often requires pharmacological analgesic therapy for pain management. This study aims to determine the profile and characteristics of analgesic use in myalgia patients at Puskesmas Soromandi. Data were obtained through a retrospective study of patient medical records from January to December 2023, using consecutive sampling method. The data were analyzed descriptively and presented in tables and percentages. The results show that the most common demographic groups using analgesics for myalgia were patients aged 46-65 years (46.53%), female (57.4%), and farmers (48.5%). The most frequently used analgesic was ibuprofen 400 mg (40.59%), which was more often combined with supplements rather than used as monotherapy. The most common duration for analgesic administration was 5 days (56.43%). Conclusion: Myalgia patients are generally aged 46-65 years, with a predominance of females and farmers. Ibuprofen and a 5-day duration of analgesic treatment are the most frequently applied approaches in myalgia cases at Puskesmas Soromandi.
Application of Jigsaw Type Cooperative Learning Model to Improve Conceptual Knowledge and Problem Solving Ability of Senior High School Students
Authors: Shofa Nada , Supriadi Supriadi , Aldoko Wisnu
Published: January 2025

This study proves that the Jigsaw type cooperative learning model can improve the conceptual knowledge of students on thermochemistry material, which is a learning model that has an influence on improving students' conceptual knowledge of thermochemistry. It aims to improve students' conceptual knowledge and problem solving ability through the application of the Jigsaw type cooperative learning model, taking into account the students' basic mathematics ability level which is classified into three categories: low, medium, and high. This research used quasi-experiment method with pretest-posttest control group factorial design. The subjects of the study were students of class XI IPA at SMA Negeri 06 Bombana, Bombana Region. Data were obtained through conceptual knowledge test, problem solving ability test, and student response questionnaire. The results showed that the conceptual knowledge of students who followed the Jigsaw type cooperative learning model was quantitatively higher than that of students who followed the conventional learning model. The results showed that the conceptual knowledge of students who followed Jigsaw cooperative learning was quantitatively higher than that of students who followed conventional learning. The same applies to problem solving ability, where students with the Jigsaw model showed quantitatively higher results compared to conventional learning students. the increase in conceptual knowledge was greater in the Jigsaw group compared to conventional learning. The level of students' basic mathematics ability did not affect the increase in conceptual knowledge, but did affect the increase in problem solving ability. Students gave positive responses to the Jigsaw type cooperative learning model, stating that this model was fun, easy to follow, and increased learning motivation.
Evaluating Glycerol's Performance as a Sustainable Dehydrator in Ethanol Purification
Authors: Muhali Muhali , Hulyadi Hulyadi , Bayani Faizul
Published: January 2025

This research aims to evaluate the effectiveness of glycerol as a dehydrator in the process of purifying ethanol solutions. This study is a quantitative descriptive research aimed at analyzing the effectiveness of glycerol, derived from used cooking oil, as a water dehydrating agent in the ethanol purification process. Data obtained will be quantitative and statistically analyzed to evaluate glycerol's performance as a dehydrator. The research was conducted at the Chemistry Laboratory of Mandalika Education University (UNDIKMA) over a specific period according to the research schedule.Independent Variable is glycerol from used cooking oil as a dehydrating agent. The concentration of glycerol used is determined based on the percentage of glycerol in the ethanol solution. Dependent variable the effectiveness of ethanol purification, measured through the comparison of density and percentage of standard bioethanol and Controlled variables is Temperature and pressure during the dehydration process, duration of the purification process, and the initial ethanol concentration before purification. Data analysis uses a simple regression curve that follows Lambert Beer's law. In conclusion, the results obtained (increasing the ethanol concentration to 90.5%) show that glycerol is a very effective dehydrator in reducing water content, especially for solutions with high water content such as ethanol at an initial concentration of 23.3%.
The Importance of Family Involvement in the Treatment of Pediatric Obsessive-Compulsive Disorder
Authors: Gorbis Eda , Yip Jenny C , Jajoo Aanya
Published: January 2025

Pediatric Obsessive-Compulsive Disorder (OCD) is a chronic condition that disrupts mental health, family dynamics, and social functioning, often requiring family involvement for effective treatment. This paper explores how family accommodation reinforces symptoms and highlights evidence-based interventions, such as Family-Based Cognitive Behavioral Therapy (FB-CBT) and Exposure and Response Prevention (ERP), to reduce these behaviors and foster long-term recovery. Cultural considerations, diagnostic challenges, and the role of siblings and extended family are discussed, emphasizing the importance of tailored and inclusive approaches. Strategies to overcome barriers to family engagement, including psychoeducation, telehealth options, and motivational interviewing, are presented alongside case examples to illustrate practical applications. Finally, the paper calls for further research into culturally adapted interventions, technology-assisted therapies, and long-term outcomes to ensure sustainable, accessible, and family-centered care. By addressing these complexities, the paper provides a comprehensive roadmap for clinicians and families navigating pediatric OCD treatment.
Changes in Smooth Muscle Cell pH during Hypoxic Pulmonary Vasoconstriction: A Possible Role for Ion Transporters
Authors: Madden JA , Keller PA , Kleinman JG
Published: January 2025

Hypoxic pulmonary vasoconstriction (HPV) occurs in smooth muscle cells (SMC) from small pulmonary arteries (SPA) and is accompanied by increases in free cytoplasmic calcium ([Ca2+]i) and cytoplasmic pH (pHi). SMC from large pulmonary arteries (LPA) relax during hypoxia, and [Ca2+]i and pHi decrease. Increases in pHi and [Ca2+]i in cat SPA SMC during hypoxia and the augmentation of hypoxic pulmonary vasoconstriction by alkalosis seen in isolated arteries and lungs suggest that cellular mechanisms, which regulate inward and outward movement of Ca2+ and H+, may participate in the generation of HPV. SMC transport systems that regulate pHi include the Na+-H+ transporter which regulates intracellular Na+ and H+ and aids in recovery from acid loads, and the Na+-dependent and Na+-independent Cl–/HCO3– transporters which regulate intracellular chloride. The Na+-dependent Cl–/HCO3– transporter also aids in recovery from acidosis in the presence of CO2 and HCO3–. The Na+-independent Cl–/HCO3– transporter aids in recovery from cellular alkalosis. The Na+-H+ transporter was present in SMC from SPA and LPA of the cat, but it seemed to have little if any role in regulating pHi in the presence of CO2 and HCO3–. Inhibiting the Cl–/HCO3– transporters reversed the normal direction of pHi change during hypoxia, suggesting a role for these transporters in the hypoxic response. Future studies to determine the interaction between pHi, [Ca2+]i and HPV should ascertain whether pHi and [Ca2+]i changes are linked and how they may interact to promote or inhibit SMC contraction.
Study of Solutions of Singularly Perturbed Equations by Splitting and Replacing Initial Conditions with Varying Initial Conditions
Authors: Alybaev K. , Musakulova N.
Published: January 2025

Рассматривается сингулярно возмущенное уравнение (СВУ) первого порядка. Основная задача заключается в расщеплении решения заданного уравнения на несколько (конечных) составляющих, так чтобы каждая составляющая была доминирующей в разных частях рассматриваемой комплексной области и упростила проводимые исследования. Для облегчения проводимых исследований проведена замена начальных условий на переменные начальные условия на некоторых линиях. Abstract. In this paper, a singularly perturbed equation (SPE) of the first order is considered. The main task is to split the solution of the given equation into several (finite) components, so that each component is dominant in different parts of the considered complex region and simplifies the conducted research. To facilitate the conducted research, the initial conditions are replaced by variable initial conditions on some lines.
Free-Living Protozoa (Ciliates and Testate Amoebae) in the Fresh Waters of the Nakhchivan Autonomous Republic
Authors: Seyidova L.
Published: January 2025

In the period from 2017 to 2022, ciliated protozoa and testate amoebae were studied in freshwater ecosystems of the Nakhchivan Autonomous Republic. 110 species of ciliates and 65 species of amoebae were identified. The species diversity of ciliates in freshwater is almost twice as high as in soil. The differences in species diversity between aquatic and soil amoebae are relatively small. The need for standardization of the methods used by researchers is emphasized. Further studies of these groups of protozoa are necessary to obtain more accurate conclusions about their ecological role, relationships, and their importance in various biological processes.
Assessing the Environmental Impact of the Mining Industry
Authors: Abasov B.
Published: January 2025

Mining is very vital to the production of goods, services and infrastructure; it advances the quality of lives in the society. However, the possible hazard of waste and radioactivity generated by mining, dumping and tailing, has called on the society to find ways of seeking remedy that will adequately treat mining waste from mine dump, tailing and abandoned mine. Mine waste reuse and recycling in mining industries could offer cost-effective benefits through offsetting raw material requirements and decreasing the volumes of waste to be managed. Impact and mechanism of mine damage to the environment was discussed together with the remediation principles. Practical ways in which country’s state authority and civil society can keep a close watch and enhance the enforcement of laws and regulations were highlighted. The prediction for the control of mineral exploration and environmental assessment was also discussed for executing a specific control to take preventive measures.
Phytotoxicity and Bioremediation of Soils in Binagadi District of Baku City
Authors: Ismayilov N. , Aliyeva N.
Published: January 2025

On the territory of the Binagadi administrative district of Baku, the area of oil-contaminated lands is 2,627 hectares. The content of oil products in the soil fluctuates between 0.9-2.4%. This corresponds to a very high level of pollution. Oil-contaminated soils of the Binagadi district are characterized by a high degree of phytotoxicity of 20-80%. Soil purification using the method of complex bioremediation is proposed.
Determination of the Critical Value of the Well flow Rate during Fountain Operation
Authors: Orujov Yu. , Abishova R.
Published: January 2025

The purpose of this study is to propose a method for determining the critical flow rate in flowing wells to prevent the collapse of the productive formation, taking into account the homogeneity of the rocks. The concept of critical flow rate is associated with many disputes in the community of engineers involved in the development of oil and gas deposits. First of all, questions are raised by the existing analytical methods for determining the critical flow rate. Calculations were made and the critical value of the well flow rate was determined, at which a collapse of the formation may occur.
Multidisciplinary Approach in the Treatment of Gastric and Duodenal ulcer Complicated by Bleeding
Authors: Dzhaksymbaev N. , Niyazov B. , Abdyldaeva V. , Abdyldaeva V. , Dinlossan O. , Niyazova S.
Published: January 2025

A multidisciplinary team is a team of specialists from different fields of medicine, united by the solution of one problem on previously agreed principles. A possible example of this approach in the treatment of gastric ulcer and duodenal ulcer complicated by bleeding is the joint interaction of doctors - general surgeons, endoscopists, gastroenterologists, general practitioners, therapists, nutritionists, psychologists. Since these specialists often encounter these dangerous diseases, a joint approach to their treatment is fully justified. When considering many medical problems, cooperation and joint work of several at once is necessary, both narrow specialists and general practitioners who work in the same team and try to achieve a common goal. In modern world medical practice, this approach is used more and more, because it allows you to combine the knowledge of different doctors, for the benefit of the patient and make the treatment closer to this patient. Today, a multidisciplinary approach of a team of doctors of different specialties is increasingly engaged in the treatment of patients in the world's leading clinics. It is believed that this approach has a future, because it allows to easily and quickly determine the sequence and priority of treatment methods. Also, recommendations to the patient are given in agreement and situations where one contradicts the other are excluded. Collegiality is observed.
Analysis of Human Resources Assessment in Laboratories of Public Health Organizations Bishkek
Authors: Seksenbaeva B. , Rozyeva R. , Zhoroev A. , Adilbaeva V. , Mamatova K.
Published: January 2025

This article provides information on the importance of laboratory services for the effective treatment process of patients. At the same time, assessing the human resources potential of laboratory services remains currently an urgent task, the solution of which requires a standardized approach and methodology. To address this issue, documents have been developed that provide guidance for assessing the human resources used to assess the public health laboratory system.
Sociological Survey using Questionnaires for Children with Psychoneurological Disorders to Identify Dental Well-being in the Kyrgyz Republic
Authors: Dzumalieva M.
Published: January 2025

For the first time, a sociological survey was conducted using the questionnaire method among children with psychoneurological diseases to identify dental well-being in the Kyrgyz Republic. The largest number of those who took part in this study were parents of children aged 4-5 years (23.1% of cases) and 6-7 years (18.4% of cases). According to the results of the survey, it was revealed that the most common disease among children is cerebral palsy and ASD. The largest number of families with children with disabilities live in the Chui region and in the capital of the country. Most often, those respondents whose
Agrochemical Characteristics of Yellow Earth-Pseudopodzolic Soils of the Lenkaran District of Azerbaijan
Authors: Babayev H.
Published: January 2025

The work is devoted to the study of pseudopodzolic-clay-yellow earth soils. Citrus fruits grown on pseudopodzolic-clay-yellow earth soils are one of the most important crops in Azerbaijan. The main citrus plants grown in the Lankaran-Astara region are lemons, tangerines and oranges. Studies of soils under citrus plantations showed that the amount of total humus in soils under lemon fluctuates within 1.60-2.80%. Agrochemical indicators of soils under lemons showed a decrease in soil fertility. In conclusion, the author gives recommendations for improving the chemical composition of the studied soils.
The Effect of Bacillus subtilis Microbial Fertilizer on Fungal Diseases in Tomato (Solanum lycopersicum L.) Plants
Authors: Valiyeva N. , Ramazanova G. , Allahyarova S. , Mammadova A. , Mammadova S.
Published: January 2025

The study was conducted to investigate the effect of Bacillus subtilis on tomato plant diseases. The study area is Samukh district of the Republic of Azerbaijan. Our studies were conducted on experimental plants in the laboratory of plant disease diagnostics of the Azerbaijan State Agrarian University. The experiment was conducted in 3 variants: control, application of microbial fertilizer (MGT), standard application of fertilizer + application of Bacillus subtilis (SGT + MGT). Tomato plant cuttings are planted in pots after application of microbial fertilizer (1 ml / 10 l). At the beginning of flowering, fertilizer (1 ml / 100 l) was applied as a spray on the leaves. When comparing the experimental variants, it was confirmed that high tomato yield and disease resistance are observed when using microbial fertilizer. The study of the effect of Bacillus subtilis bacteria on tomato plant diseases has not been previously conducted in Azerbaijan.
Problems of Legal Socialization of Personality
Authors: Kolsarieva N. , Ismailov E.
Published: January 2025

The article is devoted to an actual topic, its relevance is due to the sharp and frequent changes in society, generating changes in the legal policy of the state. The key role in the article is given to the personality and the process of its legal adaptation. In the article such concepts as “personality”, “socialization”, “legal socialization” are disclosed and specified. This article attempts to study the process of legal adaptation of the individual to the legal norms and rules established in society, and also investigates the processes of desocialization and resocialization as concomitant factors of legal socialization. In the framework of the research, its subject, purpose, methods were determined, and the relevant conclusions were made. The purpose is defined as the study of problems caused in the process of legal socialization of the individual, and the subject of the study is the process of legal socialization itself. In the study of this topic, comparative-legal, concrete-sociological methods of cognition were used, which allowed us to obtain the most detailed information on the topic.
Practical Value of Intensive Learning, use and Development of Communicative Skills for Students of Mathematics Based on Professional English Language
Authors: Bekmatova Zh. , Mukambetova A. , Madmarova Z.
Published: January 2025

Research relevance: the article deals with the special application of methods and techniques that have shown their effectiveness in world practice for the successful implementation of professional communication of mathematicians-students in English. Research purpose: clarification in a practical context of the objective aspects need for methods to achieve the expected results in teaching English in the system of higher mathematical professional education in Kyrgyzstan. Research materials and methods: analysis of their influence on the development of the professional speech of mathematicians-students through the views of students who studied this question, and also the ways of verifying these methods in practice are proposed. The content of these methods is revealed in the article, taking into account public and social conditions. This is related to the task of preparing mathematicians-students for international competition by forming professional English language at the required level, and also demonstrates the content of methods used in practice with examples. Research results: on the basis of the proposed points, a number of problems in teaching English in the field of professional education and mathematics are highlighted. Conclusions: a comprehensive approach is required to improve the teaching of English in mathematics.
The Role of the Russian Language as a Means of Conveying Thoughts and Communication
Authors: Umarova D.
Published: January 2025

The article explores the development of the Russian language as a complex and multifaceted process, encompassing not only the establishment of grammatical and lexical norms but also the crucial role of language in thinking and communication. Language is viewed as a tool for conveying thoughts and facilitating communication, contributing to the development of cognitive functions such as memory, attention, and logical thinking. The influence of cultural, social, and historical factors on speech development is emphasized, alongside the interaction of language with mass media, the internet, and modern culture. The article highlights the importance of education in developing speech skills and fostering critical thinking. Technology is seen as a complement to traditional teaching methods, enhancing the effectiveness of the educational process. Ultimately, the Russian language is presented as a dynamic system that plays a key role in social and cultural life.
Family as Part and Whole in Mountain Communities: The Influence of Climate and Ecology on Family Structures
Authors: Zulpukarov K. , Keldibaeva N. , Ismanova G.
Published: January 2025

This article explores the concept of family as both a part and a whole within mountain communities, focusing on how climate and ecological conditions shape family structures and dynamics. Mountain environments present unique challenges, such as harsh weather conditions, limited resources, and geographical isolation, which significantly influence the way families organize, interact, and support each other. The study examines how these environmental factors foster a collective resilience among family units, emphasizing interdependence, communal support, and adaptation strategies that are distinct to mountainous regions. By analyzing the interplay between ecological conditions and social structures, the article highlights the critical role of the environment in shaping familial relationships and communal cohesion. This research contributes to a broader understanding of how families function as both individual units and integral parts of larger social and ecological systems in mountain communities.
Gastronomic Code of Culture in the Paremiological Picture of the World of English, Kyrgyz and Russian Languages
Authors: Kabylov T. , Usmanova A. , Baktybekkyzy N.
Published: January 2025

The article is devoted to the study of the gastronomic code of culture in the context of the paremiological picture of the world of English, Kyrgyz and Russian languages. The research is carried out through the construction and analysis of the figurative lexical and phraseological field "Food" in order to identify the features of the reflection of national cuisine in the linguistic picture of the world. The analysis shows that the conceptualization of the gastronomic code through proverbs and sayings is characterized by a variety of forms of expression and deep socio-cultural content. This code is characterized by a complex structure and a multi-layered associative-semantic field, and its basic concepts are represented by a wide range of language tools. The author concludes that the gastronomic code of culture is a universal phenomenon, occupying a special place in the linguistic cultures of English, Kyrgyz and Russian languages. Its importance is confirmed by the high frequency of reflection in proverbs and sayings, which emphasizes the specifics of the perception of the world by different ethnic groups.
Climatic Conditions in Mountains Through the Lens of Indefinite Pronouns: A Linguo-Cultural Approach
Authors: Shermatova A.
Published: January 2025

This article explores the use of indefinite pronouns in the context of describing climatic conditions in mountainous regions, utilizing a linguo-cultural approach. By comparing English and Kyrgyz languages, the study examines how indefinite pronouns function semantically and pragmatically in narratives and descriptions of mountain climates. The research highlights how these pronouns reflect cultural perceptions and attitudes towards nature and the environment. The findings demonstrate that indefinite pronouns are not merely grammatical tools but are deeply embedded in the cultural narratives that shape the understanding of mountain climates. This study contributes to the broader field of linguistics by revealing the interconnectedness of language, culture, and environmental perception.
PROTECTION OF RIGHTS TO THE RESULTS OF INTELLECTUAL ACTIVITIES IN THE IMPLEMENTATION OF CUSTOMS CONTROL: PROBLEMS OF TERMINOLOGY AND DIRECTIONS OF IMPROVEMENT
Authors:   Institute of State and Law of the Russian Academy of Sciences, Moscow, Russian Federation, LETOVA ELIZAVETA A.
Published: January 2025

The article examines the features of customs regulation of goods containing an intellectual property object, in particular, the features of customs regulation of goods subject to export control. The main approaches to defining the concept of «goods containing an intellectual property object» are analyzed, the terminology used, which has different meanings within the framework of customs legal regulation and legal regulation in the field of intellectual property, is analyzed. The main problems of implementing customs control in relation to such objects are identified, the subject composition and ratio of customs and export control are determined, ways to improve customs protection of rights to the results of intellectual activity in order to achieve a balance of interests of the state and copyright holders are proposed.
Implementasi Budaya Religius Dalam Pembentukan Karakter Siswa Peserta Didik Di MAN 3 Jombang
Authors: Nafilah Mu’tafiyah Bika , Abdul Gofur  , Rizki Khoirunni
Published: January 2025

Penerapan budaya religius merupakan strategi yang efektif dalam membentuk karakter siswa di era digital. Penelitian ini bertujuan untuk menganalisis implementasi budaya religius di MAN 3 Jombang dan dampaknya terhadap pembentukan karakter siswa. Penelitian menggunakan pendekatan kualitatif dengan metode studi kasus, melalui observasi, wawancara mendalam, dan analisis dokumen. Hasil penelitian menunjukkan bahwa budaya religius yang diterapkan melalui pembiasaan membaca Al-Qur'an, shalat berjamaah, peringatan hari besar Islam, dan kegiatan ekstrakurikuler Rohis berhasil membentuk karakter siswa dalam aspek kedisiplinan, tanggung jawab, solidaritas sosial, dan empati. Peran guru sebagai role model sangat signifikan dalam menginternalisasi nilai-nilai religius. Namun, tantangan seperti pengaruh media sosial dan kurangnya kesadaran intrinsik siswa perlu diatasi dengan pendekatan reflektif, penggunaan teknologi secara positif, dan pelibatan keluarga dalam mendukung program keagamaan. Penelitian ini memberikan kontribusi praktis bagi sekolah lain dalam mengintegrasikan nilai-nilai religius untuk memperkuat pendidikan karakter siswa
APPLICATION SOCIO SCIENTIFIC ISSUES (SSI) APPROACH TO IMPROVE STUDENTS’ PHYSICS CONCEPT UNDERSTANDING ABILITY
Authors: Valen Anissa , Sri Jumini
Published: January 2025

The rality that occurs in the field is that the ability to understand physics concepts is still weak. This can be seen frpm the teacher only using learning in the classroom only teaching abstract physics. Therefore, an appropriate learning method is needed so that learning objectivites can be achieved. This study aims to improve the ability to understand the concept of physics by applying the SSI approach. The research method used experiments with experimental classes and control classes as samples determined using random sampling techniques. Data analysis techniques using t-test, and N-Gain test, data processing assisted using SPSS software. The results showed that there was a difference in impoving the ability to understand the concepts of physics, namely tcount 7,40 > ttable 2,045 and hand a significant value of less than 0,05. The N-Gain Score of the experimental class is 0,74 with a high category, while the control class is 0,19 with a low category. Therefore, the application of the SSI approach can improve the ability to understand student’s physics concepts.
VALIDITY OF BITARAKSA (SPACE ORBIT) AS A LEARNING MEDIA IN CLASS VII SOLAR SYSTEM MATERIAL
Authors: Dyah Ismi Safitri  , Noer Af’idah
Published: January 2025

Learning media is a tool that can convey information from teachers to students. This is because the use of learning media can make learning activities more efficient. However, so far teachers still rarely use learning media. This causes learning activities to seem boring and students often experience difficulties in understanding the material. The solar system matari in science lessons is one of the materials that requires learning media. The purpose of this study is to determine the validity of the development of bitaraksa media in learning solar system science for grade VII junior high school students. This study uses the ADDIE development method, which consists of five stages, namely the analysis stage, the design stage, the development stage, the implementation stage, and the evaluation stage, but in this study the implementation stage is not carried out. The validity test was carried out by media assessment by media expert Validators, material experts and junior high school science teachers. From filling out the validation sheet, results were obtained in the form of qualitative and quantitative data. The quantitative data obtained was processed to obtain the validity value of the developed bitaraksa media. Meanwhile, qualitative data in the form of suggestions and inputs are used as a reference to improve and revise bitaraksa media developed by researchers. Based on the results of quantitative data, the average score of 87.1% of the bitaraksa media validation assessment was obtained, the category was very valid.
Development and Validation of a Water-to-Air Heat Pump Model using Modelica
Authors: Zhang Yuhang , Liu Mingzhe , Yang Zhiyao , Calfa Caleb , O’Neill Zheng
Published: January 2025

Water-to-air heat pumps are widely used Heating, Ventilation, and Air Conditioning (HVAC) devices due to their versatility and energy efficiency. However, there is a scarcity of readily available Modelica models that support reversible operation (heating and cooling modes), use compressor speed as the control signal, and accurately predict the system performance. To address this gap, this paper presents a speed-input water-to-air heat pump model developed using Modelica. Performance curves are employed to represent the functionality and predict the system’s capacity and power usage. To validate the proposed model’s effectiveness, manufacturer-provided data are used to generate the performance curves. The model, based on these curves, is then used to simulate testing conditions, which are implemented in a real heat pump testbed. The comparison between simulated and measured values shows that the errors during normal operation stages are within an acceptable range, demonstrating the effectiveness of the developed water-to-air heat pump model.
Advancements in Building-to-Grid Interactions: Thermo-Electric Coupling Models of Motor-Driven Devices
Authors: Ganesh Viswanathan , He Zhanwei , Zuo Wangda
Published: January 2025

Building-to-grid (B2G) integration transforms buildings into active components of the electricity grid, enhancing dynamic energy management and optimizing usage to reduce operational costs and carbon emissions. However, existing modeling tools for building and power systems often overlook or oversimplify the interactions between power system dynamics and building dynamics. This paper introduces Modelica-based thermo-electric coupling models for motor-driven devices in buildings, such as pumps and heat pumps. The developed models assess transient oscillations and negative active power in these devices within B2G systems. We compare the proposed models with a base model from the Modelica Building Library that uses a radiator and heat pump to maintain room temperature. The simulation results demonstrate that the motor-driven models effectively capture transient oscillations in current and power when the systems are activated and deactivated. Additionally, the occurrence of negative power when systems turn off is a critical factor in enhancing B2G system stability and energy efficiency. These findings underscore the model’s ability to improve grid support, advancing energy management practices in B2G applications.
Objectively Defined Intended Uses, a Prerequisite to Efficient MBSE
Authors: Rosenlund Erik , Hällqvist Robert , Braun Robert , Krus Petter
Published: January 2025

This article proposes a method for improved model verification within Large-Scale Simulators (LSS). The approach relies on machine-interoperable traceability of model verification information, such as model Operational Domains (ODs). This enables automated evaluation of model relevance and facilitates the combination of models for a broader evaluation of credible simulation results. The paper introduces a proof-of-concept testbed for verification of black-box models against model requirements. Furthermore, the results also include a proposal for a machine-readable format to capture model requirement Verification & Validation (V&V) results, along with the resulting model and updated model OD information.
Function of formyl peptide receptor 2 in adriamycin resistance of breast cancer
Authors: Su Landi , Li Jingjing , Qin Li , Feng Yang , Xu Dingwen
Published: January 2025

FPRL2 has been shown to be associated with a variety of tumours but has not been well studied in breast cancer. In this study, We combine molecular biology techniques with bioinformatics to analyze the role of FPRL2 in breast cancer and adriamycin resistance. By utilizing bioinformatics, we mine TCGA and GEO public databases to assess FPRL2 expression in breast cancer patients and its correlation with patient prognosis. Additionally, we employ the DepMap tool to probe the CCLE database, examining the relationship between FPRL2 gene effects and adriamycin sensitivity. Chemosensitivity of Adriamycin in breast cancer cells was tested by CCK-8 method. The apoptosis of breast cancer cells was determined by flow cytometry assay. Expression of p-ERK5 and p-AKT was determined by Western blot assay. Our results indicate that the expression level of FPRL2 in tumor tissues of breast cancer patients is significantly higher than that in normal tissues, and it correlates with poor prognosis in patients. Furthermore, the expression level of FPRL2 in tumor tissues of adriamycin-resistant breast cancer patients is also significantly higher than that in adriamycin-sensitive patients. The IC50 (Inhibitory Concentration 50). Of Adriamycin was significantly lower in FPRL2 silenced cells than those control cells. The apoptosis was markedly increased in FPRL2-silenced cells. p-ERK5 and p-AKT in breast cancer cells was significantly reduced after FPRL2 knocked down. In Conclusion, FPRL2 mediates Adriamycin resistance in breast cancer cells, and knockdown of FPRL2 increased apoptosis and decreased Adriamycin resistance in breast cancer cells.
Nomophobia, phubbing, and deficient sleep patterns in college students
Authors: Guerra Ayala Margit Julia , Alegre de la Rosa Olga María , Chambi Catacora Maria Amparo del Pilar , Vargas Onofre Elizabeth , Cari Checa Edith , Díaz Flores Débora
Published: January 2025

In the current context, excessive mobile device use has led to new issues, such as nomophobia—an irrational fear of being without a mobile phone—and phubbing, which involves ignoring nearby people in favor of using one’s phone. These behaviors are increasingly prevalent among young people, particularly in university settings, and can negatively impact well-being, including the emergence of poor sleep patterns. Given that sleep is essential for academic performance and mental health, examining how nomophobia and phubbing relate to disruptions in university students’ sleep habits is crucial. This study aimed to analyze the correlation between nomophobia, phubbing, and poor sleep patterns among university students, determine whether nomophobia and phubbing are significant predictors of these patterns, and examine the individual contribution of each variable on sleep. A non-experimental, cross-sectional, quantitative design with correlational-explanatory scope was used, conducted from March to June 2023. The sample consisted of 533 students from a private university in Peru, aged 18 to 24, selected through non-probabilistic sampling. Data were collected using the Short Nomophobia Questionnaire (SNQ-5) and the Brief Phubbing Scale (BPS-6), validated instruments with strong internal consistency. The results showed moderate positive correlations between nomophobia, phubbing, and poor sleep patterns. Linear regression analysis indicated that the predictor variables explained 45.1% of the variance in poor sleep patterns. Nomophobia significantly affected all three analyzed sleep patterns (late nights, insomnia, and short sleep), whereas phubbing significantly impacted only short sleep. The findings underscore the importance of addressing excessive mobile device use in university settings, as both nomophobia and phubbing affect students’ sleep quality. Future research is recommended to explore their impact on mental health and evaluate interventions to mitigate these phenomena and their implications for academic performance.
Prevalence and predictive factors of testosterone-induced erythrocytosis: a retrospective single center study
Authors: Neidhart Anina , von Wyl Viktor , Käslin Benno , Henzen Christoph , Fischli Stefan
Published: January 2025

Aim

This study analyzes the prevalence and predictive factors of testosterone-induced erythrocytosis (TIE) in patients receiving testosterone replacement therapy (TRT).

Methods

Retrospective single-center observational study.

Results

247 patients were included; median age was 47.0 years (interquartile range (IQR) 32-60) and median follow-up years 2.9 (1.0-5.5). The most common indication for TRT was central hypogonadism (51%) followed by primary hypogonadism (26%). TRT was carried out with testosterone undecanoate (TU) n=194, testosterone enanthate (TE) n=18 and testosterone gel (n=35). Compared to baseline, hematocrit (HCT) values at last follow-up (LFU) increased significantly by +0.04 (95% confidence interval (CI) [0.027, 0.050], p=<0.0001) in all patients (n=92) and +0.06 (95%CI [0.031, 0.057], p<0.0001) in the TU group (n=71). 57% of the patients reached an HCT value>0.46, 23% >0.5 and 5%>0.54. 46% of the patients who have reached an HCT value >0.46 have had their highest HCT measurement within the first year of TRT application. Logistic regression analysis indicated that body mass index (BMI) was significantly associated with the development of an HCT ≥0.5 (p=0.013) and HCT ≥0.46 (p=0.008). There was an association between the baseline HCT measurement and the outcome of a HCT measurement ≥0.46 (p=0.025), patients with high starting values were more likely to develop TIE.

Conclusions

TIE appears to be frequent and does not only present within the first year of therapy which indicates a close follow-up of laboratory values within the first year followed by annual controls. Baseline BMI and baseline HCT measurement should be considered in risk stratification of TIE development.
Short-term output prediction of wind-photovoltaic power based on time-frequency decomposition
Authors: Zhang Yangfan , Fu Xuejiao , Wang Yaohan , Wang Zhengyu , Wang Xiaoxiao
Published: January 2025

This paper proposes a short-term wind and photovoltaic power forecasting framework considering time-frequency decomposition based on bidirectional long short-term memory networks. First, the seasonal and trend decomposition using loess is applied to the original wind and photovoltaic data for time domain decomposition, obtaining trend, seasonal, and residual components. Then, the residual component undergoes variational mode decomposition to further extract features of different frequencies. Next, the maximum information coefficient is used to select features, which is highly correlated with wind and photovoltaic power as input features to the prediction model. Finally, the selected features are input into bidirectional long short-term memory networks for training and prediction. Experimental validation using actual data from a photovoltaic station and a wind power station in Hebei Province, China from July to August 2023, which shows that the proposed method achieves high accuracy and reliability in photovoltaic and wind power output prediction. The proposed time-frequency decomposition with the smallest root mean square error of 0.92 and mean absolute error of 0.58 in photovoltaic prediction, at the same time, the smallest root mean square error of 67.5 and mean absolute error of 48.16 in wind power prediction, significantly outperforming other power prediction methods.
Suppression of MCP-1, IFN-γ and IL-6 production of HNSCC ex vivo by pembrolizumab added to docetaxel and cisplatin (TP) exceeding those of TP alone is linked to improved survival
Authors: Wellhausen Jana , Röhl Louisa , Berszin Michael , Krücken Irene , Zebralla Veit , Pirlich Markus , Stoehr Matthaeus , Wiegand Susanne , Dietz Andreas , Wald Theresa , Wichmann Gunnar
Published: January 2025

Background

Adding pembrolizumab, an anti-PD-1 antibody approved for treatment of head and neck squamous cell carcinoma (HNSCC) to neoadjuvant (induction-) chemotherapy utilizing docetaxel and cisplatin (TP) followed by radiotherapy may improve outcome in larynx organ-preservation (LOP) that is investigated in the European Larynx-Organ preservation Study (ELOS). As biomarkers for response to TP and pembrolizumab +TP are missing but may include cytokines, this work aims on determining cytokines potentially linked to outcome as prognostic markers sufficient to predict and/or monitor response to successful LOP.

Methods

Collagenase IV digests were generated from 47 histopathological confirmed HNSCC tumor samples and seeded in 96-well plates containing pembrolizumab, docetaxel, cisplatin either solely or in binary or ternary combination. According to the FLAVINO protocol, supernatants were collected after 3 days, adherent cells fixed using ethanol, air-dried and pan-cytokeratin positive epithelial cells counted using fluorescence microscopy. The cytokines IL-6, IL-8, IFN-γ, IP-10, MCP-1, TNF-α, and VEGF in the supernatant were quantified by sandwich ELISA.

Results

The mode of interaction between pembrolizumab and TP was assessed and correlated to outcome (overall, disease-specific and progression-free survival of patients). Suppression of MCP-1, IFN-γ and IL-6 production by pembrolizumab + TP exceeding the suppressive effect of TP was detected in the majority of samples and linked to improved survival. Multivariate Cox proportional hazard regression modeling revealed MCP-1, IFN-γ and IL-6 as independent outcome predictors.

Conclusions

Comparing response to TP vs. pembrolizumab vs. TP + pembrolizumab may allow for identification of patients with superior outcome independent from treatment applied.
Acute kidney injury and ANCA positivity in a patient treated with glecaprevir/pibrentasvir: a case report
Authors: Kwon Lawrence Hyun , Griffiths Jennifer , DiFranza Lanny
Published: January 2025

Background

Glecaprevir/pibrentasvir is an effective antiviral therapy for hepatitis C virus infection and is generally regarded safe in patients with renal impairment. However, renal complications are a notable, albeit rare, concern.

Case presentation

We report a case of acute kidney injury in a man in his 50s with chronic hepatitis C virus, chronic obstructive pulmonary disease, morbid obesity, a history of heroin dependence, and untreated type 2 diabetes mellitus. About four weeks into an eight-week glecaprevir/pibrentasvir regimen he developed progressive lower extremity edema, bullae, and skin ulcers with worsening renal function. His serum creatinine rose to 4.46 mg/dL and blood urea nitrogen to 44 mg/dL. ANCA serology revealed dual perinuclear and cytoplasmic positivity, though anti-proteinase 3 and anti-myeloperoxidase antibody tests were negative. Kidney biopsy revealed diffuse tubulointerstitial injury with erythrocyte casts indicative of glomerular bleeding into the distal nephrons, though without glomerular crescent formation.

Conclusion

This case illustrates the potential for glecaprevir/pibrentasvir to induce acute kidney injury, acute interstitial nephritis and possibly ANCA-associated vasculitis. Recognizing these adverse renal effects is critical for making timely diagnosis and management in hepatitis C virus patients undergoing antiviral therapy.
Integrated multidisciplinary analysis of mobile digital radiographic acquisitions of the mummies of the hermits from the Sanctuary of Madonna della Corona (Trentino-Alto Adige, Italy – 17th to 19th century CE)
Authors: Larentis Omar , Gorini Ilaria , Campus Michele , Lorenzetti Marta , Mansueto Giancarlo , Bortolotto Susanna , Zappa Emanuele , Gregorini Andrea , Rampazzi Laura , Vanin Stefano , Carta Giuseppina , Carli Alberto , Simonaitis Lara , De Luca Lisa , Tonina Enrica
Published: January 2025

Paleoradiology has become a standard diagnostic method in the study of mummified or embalmed bodies. Among the various available techniques, computed tomography valuing for its ability to provide detailed information. However, computed tomography equipment is not always accessible to research teams, cannot be easily transported to all conservation sites, and raises health concerns. Therefore, mobile digital radiographic technology is often the most suitable investigative tool in specific contexts. In this study, three mummies preserved at the Sanctuary of Madonna della Corona, perched on a cliff above the Adige River Valley on the Monte Baldo at an elevation of 775 m a.s.l., were analyzed using radiographic techniques. The impossibility of transferring the bodies due to the sanctuary’s remote location imposed the use of lightweight, portable equipment for the radiological examination. This article highlights next-generation X-ray technology utility, potential, and limitations in investigating clothing fabrics, restoration history, taphonomy, entomology, anthropology, and paleopathology. The interdisciplinary approach in this study has unveiled new historical and biological insights about these mummies, which, though revered in popular devotion, had previously been unknown to both Italian and international scientific communities.