bluuebunny/crossref_metadata_2025 huggingface dataset:
NoiBene, a Group Intervention for Promoting Mental Health Among University Students: A Study Protocol for a Randomized Controlled Trial
Authors: Di Consiglio Micaela , Merola Sheila , Satta Chiara , Pascucci Tiziana , Violani Cristiano , Couyoumdjian Alessandro
Published: May 2022

University students’ mental health has become a public health issue since increasingly students report high levels of psychological distress. Mental health difficulties influence students’ lives, such as academic performance, relationships satisfaction, and quality of life. Moreover, different kinds of obstacles often hinder help-seeking behavior. Such evidence strongly suggests the need to implement prevention and promotion strategies to increase health and well-being in educational contexts. This article presents a study protocol for implementing and evaluating NoiBene, an evidence-based group intervention that aims to promote mental health and well-being, improve a series of transversal competencies (e.g., emotional awareness, commitment to values, assertiveness, goal setting), and decrease dysfunctional transdiagnostic mechanisms (i.e., perfectionism, repetitive thinking, experiential avoidance). A randomized controlled trial will be conducted to evaluate the protocol’s efficacy. Participants will be assigned to one of the three conditions: the NoiBene Group condition (NB-G), the NoiBene guided web-based condition (NB-WB), or the waiting list condition (WLC). The NB-G intervention consists of six face-to-face group meetings, each dedicated to specific issues related to well-being or vulnerabilities. Every meeting includes an explanation of the theoretical contents, individual and group exercises, and role-plays. The NB-WB intervention covers the same topic addressed in the NB-G intervention. In this case, participants carry out a series of online modules, including theoretical explanations, practical exercises, useful activities, and self-monitoring tools. Students will individually meet the Tutor once every 2 weeks. The primary outcome will include an increase in mental health and well-being. Secondary outcomes will include changes in emotional awareness, assertiveness, perfectionism, rumination, worry, self-criticism, experiential avoidance, and academic performance and satisfaction. We expect that participants in both NoiBene conditions will show these outcomes. However, we hypothesized that the NB-G conditions will be more effective than the NB-WB in improving assertiveness. Besides treatment efficacy, we expect that students can benefit from the NB-G or NB-WB differently based on their specific behavioral and motivational patterns. Outcomes will be assessed at pre-, post-intervention and 6-months follow-up. In conclusion, we believe that NoiBene is a promising tool that can improve students’ well-being, and it could have positive implications for preventing mental health disorders among students.
Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB, and Wnt/β-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome
Authors: Maes Michael , Kubera Marta , Kotańska Magdalena
Published: May 2022

There is evidence that chronic fatigue spectrum disorders (CFAS-Ds), including myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), and chronic fatigue with physiosomatic symptoms including when due to comorbid medical disease, are characterized by neuroimmune and neuro-oxidative biomarkers. This study was performed to delineate the protein–protein interaction (PPI) network of CFAS-D and to discover the pathways, molecular patterns, and domains enriched in their PPI network. We performed network, enrichment, and annotation analyses using differentially expressed proteins and metabolics, which were established in patients with CFAS-D. The PPI network analysis revealed that the backbone of the highly connective CFAS-D network comprises NFKB1, CTNNB1, ALB, peroxides, NOS2, tumor necrosis factor (TNF), and interleukin-6 (IL-6) and that the network comprises interconnected immune-oxidative-nitrosative and Wnt/β-catenin subnetworks. Multiomics enrichment analysis shows that the CFAS-D network is highly significantly associated with cellular (antioxidant) detoxification, hydrogen peroxide metabolic process, peroxidase and oxidoreductase activity, interleukin-10 (IL-10) anti-inflammatory signaling and neurodegenerative canonical Wnt, the β-catenin complex, cadherin domains, cell–cell junctions and TLR2/4 pathways, and the transcription factors nuclear factor kappa B (NF-κB) and RELA. The top 10 DOID annotations of the CFAS-D network include four intestinal, three immune system disorders, cancer, and infectious disease. The custom Gene Ontology (GO) term annotation analysis revealed that the CFAS-D network is associated with a response to a toxic substance, lipopolysaccharides, bacterium, or virus. In conclusion, CFAS-D may be triggered by a variety of stimuli and their effects are mediated by aberrations in the cross-talks between redox, NF-κB, and Wnt/β-catenin signaling pathways leading to dysfunctions in multicellular organismal homeostatic processes.
A Comparison of Adaptive Functioning Between Children With Duplication 7 Syndrome and Williams-Beuren Syndrome: A Pilot Investigation
Authors: Alfieri Paolo , Scibelli Francesco , Montanaro Federica Alice Maria , Caciolo Cristina , Bergonzini Paola , Dentici Maria Lisa , Vicari Stefano
Published: May 2022

Interstitial deletions of 7q11.23 cause the well-known Williams–Beuren Syndrome (WBS), while duplication of the same region leads to duplication 7 syndrome (Dup7). Children with WBS share a distinct neurobehavioral phenotype including mild to severe intellectual disability, severely impaired visual spatial abilities, relatively preserved verbal expressive skills, anxiety problems, enhanced social motivation (i.e., hypersociable behaviors) and socio-communicative problems. Children with Dup7 syndrome exhibit some “inverted” features when compared to those of individuals with WBS, such as reduced social motivation and impairment of expressive language. Direct comparison of WBS and Dup7 represents a unique opportunity for the neurobehavioral characterization of the 7q11.23 section. However, most of the available data come from qualitative analysis between different studies. To the best of our knowledge, there are no studies directly comparing features of two matched samples of individuals with WBS and Dup7 syndromes. In this pilot study, we compare the adaptive functioning – measured with the Vineland Adaptive Behavior Scales, Second Edition – of two relatively small samples of children with molecularly confirmed diagnosis of WBS and Dup7 matched for IQ and chronological age, with a particular attention to socialization domain and expressive subdomain. Contrary to our assumption, we have not found any significant difference on socialization domain and expressive subdomains. This pilot investigation suggests that, when matched for chronological age and cognitive level, children with WBS and Dup7 share more similarities than expected. The inverted features that emerge in clinical settings on expressive language and social motivation seem not to differently interfere with the daily abilities to communicate and socialize with meaningful others during daily lives. Differences highlighted by previous undirected comparisons could be due to general and non-specific factors such as cognitive level, which is more severely impaired in individuals with WBS than Dup7. Implications for assessment and treatment are discussed.
Presenting a New Framework to Improve Engagement in Physical Activity Programs for Children and Adolescents With Social, Emotional, and Behavioral Disabilities
Authors: Bowling April B. , Frazier Jean A. , Staiano Amanda E. , Broder-Fingert Sarabeth , Curtin Carol
Published: May 2022

Children and adolescents with psychiatric and neurodevelopmental diagnoses such as anxiety, depression, autism, and attention-deficit/hyperactivity disorder (ADHD) face enormous health disparities, and the prevalence of these disorders is increasing. Social, emotional, and behavioral disabilities (SEBD) often co-occur with each other and are associated with unique barriers to engaging in free-living physical activity (PA), community-based exercise and sports programming, and school-based physical education. Some examples of these barriers include the significantly depleted parental reserve capacity associated with SEBD in children, child dysregulation, and previous negative experiences with PA programming and/or exclusion. Importantly, most SEBD are “invisible,” so these parents and children may face more stigma, have less support, and fewer inclusive programming opportunities than are typically available for children with physical or intellectual disabilities. Children’s challenging behavioral characteristics are not visibly attributable to a medical or physical condition, and thus are not often viewed empathetically, and cannot easily be managed in the context of programming. Existing research into PA engagement barriers and facilitators shows significant gaps in existing health behavior change (HBC) theories and implementation frameworks that result in a failure to address unique needs of youth with SEBD and their parents. Addressing these gaps necessitates the creation of a simple but comprehensive framework that can better guide the development and implementation of engaging, effective, and scalable PA programming for these youth and their families. Therefore, the aim of this article is to: (1) summarize existing research into SEBD-related child and parent-level barriers and facilitators of PA evidence-based program engagement; (2) review the application of the most commonly used HBC and disability health theories used in the development of evidence-based PA programs, and implementation science frameworks used in adaptation and dissemination efforts; (3) review the SEBD-related gaps that may negatively affect engagement; and (4) describe the new Pediatric Physical Activity Engagement for Invisible Social, Emotional, and Behavioral Disabilities (PAID) Framework, a comprehensive adapted PA intervention development and implementation adaptation framework that we created specifically for youth with SEBD and their parents.
Testing the Club Convergence Dynamics of the COVID-19 Vaccination Rates Across the OECD Countries
Authors: Xu Weibin , Lau Chi Keung Marco , Zhang Dongna , Oke Oladoke
Published: May 2022

Vaccines are essential to create a more resilient economic growth model. Ending the COVID-19 pandemic requires a more coordinated, effective, and equitable distribution of vaccines across the countries. Therefore, governments are in a race to increase the vaccination rates of the population. Given this backdrop, this paper focuses on the daily vaccinations per million data from March 1, 2021, to October 15, 2021, in 37 Organization for Economic Co-operation and Development (OECD) countries and examines the stochastic properties of the vaccination rates. We adopt the club convergence econometric methodology to investigate the club convergence paths of COVID-19 vaccination rates in OECD regions. The results indicate a significant convergence of the vaccination rates in seven clubs across 30 OECD countries. Moreover, there are seven OECD countries demonstrate non-convergent characteristics, which raises questions about ineffective vaccine balance. In addition, the paper also discusses the potential implications for the post-COVID-19 era.
Unemployed + Sick = More Deserving? A Survey Experiment on How the Medicalization of Unemployment Affects Public Opinion
Authors: Linden Philipp , Reibling Nadine
Published: May 2022

The literature on the social legitimacy of welfare benefits has shown that sick persons are perceived more deserving than unemployed individuals. However, these studies examine sick and unemployed persons as distinct groups, while unemployment and sickness are in fact strongly related. Policymakers across Europe have been increasingly concerned with discouraging a medicalization of unemployment and activating sick unemployed persons. Therefore, it is crucial to understand welfare attitudes toward this group. Using a factorial survey fielded with a representative sample of German-speaking adults (N=2,621), we investigate how sickness affects attitudes toward a hypothetical unemployed person on three dimensions: benefit levels, conditions, and sanctions. Respondents allocated similar benefit levels to unemployed persons regardless of whether they have an illness. Yet, they were more hesitant to apply existing conditions (e.g., active job search, job training) or sanction benefits when the unemployed person was also sick. This is except for conditions that tie benefits to obligatory health services (back training or psychological counseling) which was supported by the majority of respondents. Our research shows that the German public is not more generous and only partially more lenient toward sick unemployed persons as there is strong support for conditions targeted at overcoming ill health for this group. The findings underscore that sickness matters for how unemployed persons are perceived, but the impact varies across different dimensions of welfare attitudes.
Carbon Dioxide Embolism During Transanal Total Mesorectal Excision: Case Report and Literature Review
Authors: Zhu Youzhuang , Wang Weiwei , Liu Dingsheng , Zhang Hong , Chen Lina , Li Zhichao , Qin Shangyuan , Kang Yihan , Chai Jun
Published: May 2022

The actual incidence of carbon dioxide embolism during transanal total mesorectal excision (taTME) is unknown, but the reported incidence in the existing literature is reassuring. However, the incidence of CO2 embolism, which can be life-threatening, is severely underestimated. By reviewing the available data on carbon dioxide embolism during taTME and synthesizing other reports on CO2 embolism in laparoscopic procedures, we provide the first comprehensive account of the etiology, pathophysiology, and recommend tools to monitor carbon dioxide embolism during taTME. Additionally, we provide guidance and recommendations on preventive and therapeutic measures to minimize the adverse consequences of this potentially severe complication, knowledge about which we hope will improve patients’ safety.
Reconstruction of the Palmar Defect of the Hand with a Sensory Medial Plantar Artery Flap
Authors: Li Jiayu , Luo Xuchao , Zou Yonggen
Published: May 2022

Background

There are many approaches to repair the palmar defect of the hand, but due to the complex tissue structure, versatile functions, and high restoration demands, the repair of the palmar defect of the hand has always been a difficult task. Choosing suitable flaps to repair this kind of injury is always a tough challenge for the reconstructive surgeon because of the limitation of the number of arteries in the recipient hand and high restoration demands. The sensory medial plantar artery flap is considered as the ideal choice to repair the palmar defect of the hand. Based on this technique, in the current study, we used the free sensory medial plantar artery flap to reconstruct the palmar defect of the hand and obtained satisfactory results. The purpose of this study was to review the use of the sensory medial plantar artery flap for the reconstruction of the palmar defect of the hand.

Method

From January 2019 to December 2020, nine patients with the palmar defect of the hand underwent extremity reconstruction by a sensory medial plantar artery flap. The indications for this surgery were that the palmar defect of the hand need to be reconstructed and both anterior and posterior tibial arteries should be free-flowing. Patients who had systemic diseases such as diabetes millitus, vascular diseases, heavy smoking histories, and injuries of the donor site were ruled out for the surgery.

Results

Nine patients were successfully treated by using a sensory medial plantar artery flap, with a mean age of 39.44 (range 19–58) years. Five of the patients were male and the remaining four were female. Seven of them had a machine crush, and the other two suffered thermal injury. In all cases, reconstruction was performed during the second stage of treatment. All flaps survived completely, and all of the donor sites healed well in Stage 1, except for one case of ischaemic skin necrosis due to tight sutures, which healed after suture removal.

Conclusion

Our experience showed that the free sensory medial plantar artery flap was an alternative for one-stage reconstruction of the soft-tissue defect in the palm of the hand. This flexible approach not only repaired the soft-tissue defect, but also offered a satisfactory recovery of the sensory of the palm with minimal donor site morbidity.
Educational Thoughts of Perarignar C.N. Annadurai: A Content Analysis
Authors: K Chinnappan
Published: May 2022

The objective of this paper is to describe the educational thoughts and activities of Perarignar C.N. Annadurai which are present in his writings and speeches. This article uses the descriptive method and content analysis approach to do the study. His progressive thinking on objective of education, plan of education, methods of learning and teaching, instructional language, secular education, and need of educational institutions. The primary source of this article are, books authored by Perarignar C.N. Annadurai and the books written by others on C.N. Annadurai's thoughts on education and associated activities. The betterment of an individual and the social economical cultural and political progress of a nation are constructed based on the education they possess.
History and Worship of the Ettimarath Thottaththu Karuppasamy
Authors: U Vinothini
Published: May 2022

Karuppusamy is a deity worshiped in the states of Tamil Nadu and Kerala. Karuppusamy is worshiped as a tribal deity and a guardian deity. In the agrarian community, when people lived as ethnic groups, they formed a unique identity for themselves professionally as well as religiously. Some of these cults are meant to exemplify their cultural practices. Karuppasamy worship is flexible enough to adapt to the place and the circumstances of the people.
Padam in Historical Perspective
Authors: Aravinthon Suhanya
Published: May 2022

It is a fact of history that songs have appeared in Tamil art culture from time to time and have enriched the arts. Language and art are generally interdependent within the cultural elements of a community. In this way, it is possible to know through the histories that the genres of songs have changed without any change in the cultural changes that have taken place in the history of music and dance in Tamil Nadu from time to time. This article is intended as a historical overview of the genre of Padam, an item that is considered important in the Carnatic music and Bharatanatyam tradition. This article will annualize about what we mean by term, the source, content, usage of this term and other aspects in Padam.
RONALD AYLMER FISHER Y LA AGRONOMÍA
Authors: Infante-Gil Said
Published: May 2022

La inferencia estadística, como la percibimos actualmente, es un producto del siglo XX. El uso generalizado de modelos probabilísticos en las ciencias experimentales es una consecuencia de la crisis de la Física a fines del siglo XIX y de la emergencia de paradigmas tentativos en la Biología en esos años. El papel fundamental de la Estadística en la metodología científica actual tiene su génesis tanto en la confluencia de las ideas de Mendel y Darwin en la Biología, como en el derrumbe del paradigma Newtoniano. Sin duda el énfasis, a menudo exagerado, que ahora asignamos al análisis estadístico de datos experimentales, tiene su origen en la obra de Ronald Aylmer Fisher (Londres, 1890-Adelaide, 1962), el estadístico más importante en la historia de la inferencia científica. En este ensayo se intenta ubicar el desarrollo de sus ideas en el contexto del pensamiento científico de principios del siglo XX y documentar sus contribuciones a la metodología actual, subrayando que sus inmensas aportaciones a los métodos experimentales no sólo se dieron en un ambiente agronómico, sino que fueron consecuencia de ese ambiente.
ALMACENAMIENTO DE CARBONO EN LA BIOMASA AÉREA DE UNA PLANTACIÓN JOVEN DE PINUS GREGGII Engelm.
Authors: Pacheco-Escalona Felícitas Clemencia , Aldrete Arnulfo , Gómez-Guerrero Armando , Fierros González Aurelio M. , Cetina-Alcalá Víctor M. , Vaquera-Huerta Humberto
Published: May 2022

Con el objetivo de evaluar el potencial de Pinus greggii Engelm. para almacenar carbono en la biomasa aérea, se estimó la biomasa total aérea en una muestra de 20 árboles, los cuales se separaron en tallo, ramas y follaje. El estudio se llevó a cabo en una plantación de seis años de edad establecida en Cuaunepantla, Acaxochitlán, Estado de Hidalgo, México. La biomasa seca aérea promedio fue de 8.0 kg por árbol, de la cual 4.1 kg (51 %) se ubicó en tallo, 1.9 kg (24 %) en ramas y 2.0 kg (25 %) en follaje. La productividad primaria neta fue estimada en 5.8 t ha-1 año-1, para una densidad de 4425 árboles/ha. La concentración de carbono en tejido vegetal fue de 51 %. Una ecuación matemática sencilla (y = 147x + 3288x2) para estimar la biomasa de carbono a partir de la variable combinada de diámetro y altura (D2h) explicó 89 % de la variación. Estos resultados muestran que el potencial de almacenamiento de carbono en una plantación de seis años de P. greggii Engelm. es relativamente alto, con 17.9 t ha-1, que representa una masa de dióxido de carbono equivalente de 65.8 t CO2 ha-1.
The Differences of Anxiety of Pregnant Women in Trimester III on Lavender Aromatherapy
Authors: Purba Agnes , Simanjuntak Netti Meilani , Sembiring Rinawati
Published: May 2022

Childbirth can sometimes cause anxiety in pregnant women, especially in the third trimester. Pregnant women are worried about whether the baby is normal or not, the pain that will be felt and the delivery is normal or not. In order to facilitate pregnant women to go through their anxiety without complications, there are currently many being given care using lavender aromatherapy. Lavender contains substances that relax pregnant women, thereby eliminating anxiety. An initial survey conducted at PMB Erni Atika Sari, there were 19 pregnant women who said that they had anxiety in the third trimester of pregnancy, especially in the face of childbirth. Therefore, this study was conducted to determine the effect of lavender aromatherapy on the anxiety of pregnant women in the third trimester. This research was conducted with a quasi-experimental design with a non-equivalent control group design. The research location is PMB Erni Atika Sari and PMB Lismawati. The sample is primigravida third trimester pregnant women with saturated sampling with a total of 40 people. The results showed that there was an effect of giving lavender aromatherapy on the anxiety of primigravida pregnant women in the third trimester (p = 0.000). For this reason, it is expected that pregnant women can use lavender therapy as a complementary therapy that provides a relaxing effect so that it can reduce the anxiety of pregnant women facing childbirth.
Characteristic Of Environmental Sanitation in Family With Stunting Children Under Five Years Of Age
Authors: Wardani Endah Kusuma , Rofika Lutvia Dwi
Published: May 2022

Attention to malnutrition has increased in recent decades, one of which is stunting. The nutritional problem that is currently being highlighted in the world is stunting where there are around 161 million children experiencing stunting. Stunting is a measure of short height compared to age. Factors causing stunting consist of direct and indirect causes, one of which is from the aspect of environmental sanitation, namely access to clean water, sanitation and hygiene. This study aims to provide an overview of the characteristics of environmental sanitation in families with stunting children under five years of age in the Klatak and Wonosobo Public Health Centers, Banyuwangi. This research is a descriptive study and a case series design. The research subjects used were 60 stunting toddlers with proportional random sampling as the sampling technique. The variables in this study were environmental sanitation, which consisted of access to clean water, ownership of clean water facilities, ownership of bathrooms, ownership of latrines, and ownership of cattle pens. The research instrument used a questionnaire to measure the characteristics of respondents and environmental sanitation conditions, interview guidelines, observation sheets, KIA books, and weighing month reports. The data was processed using descriptive analysis. The results depicted in this study are that most of the research subjects live in families that have access to clean water, have bathrooms and latrines, but also in families who have cattle pens close to the main house. Monitoring of ownership, use, and maintenance of access to clean water, latrines, bathrooms, and livestock cages in the home environment must be carried out properly so that it can become one of the strategies in preventing stunting under five. Prevention of contamination of water, soil, and air quality is one of the ways in preventing stunting in toddlers so that toddlers can develop optimally according to their age and growth period.
Effectiveness Of Giving Biscuits To Increase Body Mass Index (Bmi) And Interpretation Of Fetal Weight In Pregnant Women Chronic Energy Deficiency
Authors: . Damayanti , Ningsih Sri Julia , Karo Karo Tati Murni , Bintang Siti Sarah
Published: May 2022

Supplemental Feeding (PMT) is a program launched by the government to improve the nutrition of pregnant women. The prevalence of pregnant women with chronic energy deficiency problems in developing countries ranges from 15-47% with a BMI of <18.5. The country with the highest prevalence is Bangladesh at 47%. While Indonesia became the fourth largest after India with a prevalence of 35.5%. The purpose of this study is to find out the effect of PMT biscuits on the increase in the body index of pregnant women and the interpretation of fetal weight in pregnant women with chronic energy deficiencies in the working area of Puskemas Sei Suka district Sei Suka Batu Baru District in 2021.

The design of this research is quantitative with an experimental quasi approach. The population in this study is all pregnant women with chronic energy deficiency Sampling techniques use consecutive sampling where the sample is taken if it meets the criteria. Data analysis using Paired Sample T Test analysis

The results of the study obtained a significant influence on the administration of PMT biscuits on the increase in BMI of pregnant women with a value of p = 0.001 and interpretation of fetal weight (IFW) p = 0.0001 had a significant influence (p < 0.05).

From the results of research, the provision of PMT in pregnant women can increase for the mother and the fetus through the interpretation of fetal weight but must be with close supervision, this is due to the attitude of mothers who do not consider the important pattern of weight gain of pregnant women but also there is a sense of boredom in the taste. In the results of the study it can be concluded that the administration of PMT biscuits can improve the welfare of the mother and fetus.
Pequenos objetos, grandes debates
Authors: Massarani Diano Albernaz
Published: May 2022

Ao objetivar estudar as representações sobre Pelé através dos selos postais emitidos por Moçambique, o presente artigo se coloca como um ponto de confluência entre dois tópicos que têm suscitado crescente interesse nos pesquisadores: a construção da imagem de Pelé, processo que recebe maior atenção por estudos no Brasil desde o início do século XXI, e o potencial simbólico dos selos postais, materiais que ao longo do mesmo período passaram a ser tratados mais amplamente como fonte de evidências por historiadores, geógrafos, sociólogos e antropólogos. Entre outros, ao sugerir que os selos postais de Moçambique atuam nos dilemas e conflitos que marcam a imagem de Pelé, as análises aqui realizadas permitem contestar a perspectiva de que os selos que não apresentariam relação aparente com a história nacional, o patrimônio cultural, a população local, e os interesses políticos do Estado emissor seriam simbolicamente vazios e comunicativamente frágeis.
Complete Blood Test as a New Prognostic Factor in Fournier’s Gangrene
Authors: Sunardi Ivan D. P. , Astram Ari , Toreh Christof , Arianto Eko , Langi Fredrik G.
Published: May 2022

Abstract: Fournier’s gangrene is a form of necrotizing fasciitis that begins in the genital and perineal areas and can extend through the fascia to the groin, thigh, and even the abdominal wall. This disease is still associated with a high mortality rate even though with comprehensive therapy. Simple examination, such as a complete blood count, is widely used as a marker of inflammation and could be used as a prognostic factor for Fournier’s gangrene. This study aimed to compare Fournier Gangrene Severity Index (FGSI) and complete blood count as a prognostic factor in Fournier’s gangrene cases by using machine learning. This was an observational study with a longitudinal data collection design according to cohort method. The results obtained 30 patients with Fournier’s gangrene at Prof. Dr. R. D. Kandou Hospital, Manado. Mortality prediction analysis using algorithms of regularized generalized linear model (GLM) and support vector machine (SVM) showed that the AUCs were 98% and 97.5% for GLM and SVM respectively for the regularized GLM and SVM in the ROC curve analysis, with the superiority to the FGSI (p<0.001). In conclusion, the complete blood count could be used as a novel prognostic value of Fournier’s gangrene cases.Keywords: complete blood count; Fournier Gangrene Severity Index (FGSI); prognostic scoring system; Fournier’s gangrene Abstrak: Gangren Fournier adalah bentuk fasiitis nekrotikans yang dimulai di daerah genital dan perineum dan dapat meluas melalui fasia ke selangkangan, paha, dan bahkan dinding perut. Penyakit ini masih dikaitkan dengan angka kematian yang tinggi meskipun dengan terapi komprehensif. Pemeriksaan sederhana seperti hitung darah lengkap, banyak digunakan sebagai penanda peradangan dan dapat digunakan sebagai faktor prognostik untuk gangren Fournier. Penelitian ini bertujuan untuk membandingkan Fournier Gangrene Severity Index (FGSI) dengan pemeriksaan parameter hitung darah lengkap sebagai faktor prognostik pada kasus dengan gangren Fournier menggunakan machine learning. Jenis penelitian ialah observasional dengan desain pengumpulan data longitudinal menurut metode kohort. Hasil penelitian mendapatkan 30 pasien dengan gangren Fournier di RSUP Prof. Dr. R. D. Kandou Manado. Analisis prediksi mortalitas menggunakan algoritma Regularized Generalized Linear Model (GLM) dan Support Vector Machine (SVM) menunjukkan bahwa AUC masing-masing sebesar 98% dan 97,5% untuk GLM dan SVM tereguler pada analisis kurva ROC, dengan keunggulan dibandingkan FGSI (p<0,001). Simpulan penelitian ini ialah pemeriksaan darah lengkap dapat dijadikan sebagai faktor prognostik baru untuk kasus gangren Fournier.Kata kunci: hitung darah lengkap; Fournier Gangrene Severity Index (FGSI); sistem skoring prognostik; gangren Fournier
KNOWLEDGE AND PRACTICE OF INFECTION CONTROL DURING WOUND DRESSING AMONG NURSES WORKING AT A TERTIARY HEALTH CARE INSTITUTION IN NIGERIA
Authors: Isioma Ofili Mary , Ogheneochuko Ayovo-E Goodness
Published: May 2022

Wound Infection is a health challenge occurring in many of our health care institutions. This study assessed nurses'
knowledge and skills of infection control during wound dressing.The relationship between their knowledge and skills of
infection control was also ascertained.A descriptive design and purposive sampling technique was employed to select
one hundred and fifty-four (18 males, 136 females) participants for the study. An interviewer's administered
questionnaire and an observational checklist were used as research instruments. Results showed that about 90% of
respondents had good knowledge of infection control. However, 65% exhibited good skills of infection control during
wound dressing. Inferential statistical analysis (Chi-square) indicated significant association between nurses'
knowledge of infection control and their skills during wound dressing (χ² = 10.902, p= 0.010). Further research is
required to identify effective strategies to enhance nurses' knowledge and practice regarding wound dressing
management.
FINANCIAL DEEPENING AND THE NIGERIAN FINANCIAL SYSTEM.
Authors: Ighoroje Ighoroje , James Ese , Othuke Emmanuel Akpokerere
Published: May 2022

The ability of financial institutions in mobilizing efficient savings for the purpose of investment in a country is financial
deepening.This study seeks to examine the effect of financial deepening on Nigerian Financial system.Specifically,the
study examine the effect of money supply to gross domestic product on financial savings to gross domestic product in
Nigeria, ascertain the effect of private sector credit to Gross Domestic Product ratio on financial savings to gross
domestic product in Nigeria,investigate the effect of market capitalization to Gross Domestic Product ratio on financial
savings to gross domestic product in Nigeria and ascertain the effect of all share index on financial savings to gross
domestic product in Nigeria.The Expo-Facto design was adopted because the data are secondary data extracted from
the Central Bank of Nigerian statistical bulletin. Econometric techniques, including Augmented Dickey-Fuller for unit
root tests, Granger causality test and Ordinary Least Square (OLS) regression analysis was used to test the four
hypotheses.The data used were collected from the Central Bank of Nigeria Statistical Bulletin.The study revealed that
broad money supply (M2/GDP),credit to private sector to GDP,market capitalization to GDP ratio and all share indexes
has positive and significant effect on financial savings to gross domestic product (FSGDP) within the period under study.
The study therefore,concludes that financial deepening have positive and significant effect on financial system and have
enhanced the effective and efficient mobilization of financial resources from the surplus to the deficit unit for investment
outlet in Nigeria financial system.The paper recommends amongst other that:Directors of economic managers should
focus on money stock,economic velocity and market capitalization which the result indicates are yet to make significant
impact on financial system in Nigeria.
HEALTHCARE SERVICE QUALITY- A REVIEW OF LITERATURE
Authors: Monika Monika , Singh Ajmer
Published: May 2022

Healthcare is a service sector with unique characteristics. Across the world public and private healthcare institutions
have been the matter of priority. There are so many studies done on the various factors of hospital like assessing
competition in hospital care market,performance relationship, and environment uncertainty in hospital,patient loyalty
in India and outside India.Healthcare Service quality is a broad concept.This paper examines the review of literature on
Healthcare Service Quality. Review of healthcare service quality was done by analysing 25 articles. The study
investigates the factor of quality affecting the value care and patient satisfaction. Patient satisfaction is an important
parameter to measure healthcare service quality level. This study is based on secondary data literature review and it
explores the important factors on Healthcare Service Quality.
FUNCTIONAL OUTCOME OF PRE-CONTOURED MEDIAL LOCKING COMPRESSION PLATE USING MIPO (MINIMaAL INVASIVEPLATING OSTEOSYNTHESIS) TECHNIQUE IN TREATMENT OF DISTAL TIBIAL FRACTURES
Authors: Shekhawat Man Singh , Jeenjwadia Nitin , Shekhawat Sumer Singh , Bhaskar S. K.
Published: May 2022

Introduction:- The management of distal tibial fractures remains challenging due to subcutaneous location of larger
portion of tibia,paucity of soft tissue coverage and precarious blood supply of distal leg.Conservative management may
be complicated by loss of reduction and subsequent malunion. MIPO (Minimal invasive plating osteosynthesis) has
evolved as a newer concept to treat distal tibial fractures. It works on Biological fixation principle which assists
physiological process of bone healing wisely with minimal operative intervention. Methods:- Prospective follow up
study carried out at J.L.N. Medical College Ajmer from 1 Jan 2017 to 30 June 2018. 30 patients with distal tibial fractures
were included and operated with pre-contoured medial locking compression plate using MIPO technique. Fractures
were classified as per AO system and patients were followed and scored according to TEENY and WISS scoring criteria.
Results:- Functional results according to TEENY and WISS scoring criteria was found excellent in 9 (30%), good in
16(53.33%), Fair in 3(10%) and poor in 2 (6.66%) patients. Poor outcome occurs due to development of complications
Conclusion:-Internal fixation of distal tibial fractures with pre-contoured medial locking compression plate using MIPO
technique is effective and safe and provides more stable construct with anatomical reduction.
EVALUATION OF PERFORMANCE OF TWO MONOPLEX QUANTITATIVE REAL TIME PCR ASSAYS IN COMPARISON TO MICROSCOPY FOR IDENTIFICATION OF MALARIA PARASITES.
Authors: Ogweno Obuya Clifford , Stephen Asito Amolo , Stewart V. Ann , N.Waitumbi John
Published: May 2022

Background: Microscopy is the gold standard for Malaria diagnosis with shortcomings such as false positives, false
negatives,errors in species identification,and errors in enumeration of parasites.Quantitative real-time PCR (qPCR) has
improved submicroscopic malaria diagnosis. This study evaluated the performance, concordance, correlation and
methods agreement of two monoplex qPCR assays against expert malaria microscopy for the detection and
enumeration of malaria parasites.
Methods: This was a cross sectional study utilizing 127 archived blood samples collected from five provinces in Kenya.
Malaria microscopy was conducted by two independent microscopists then 18S-rRNA-qPCR and non-18S-rRNA-qPCR
assays were done to identify and quantify the infecting species.The sensitivity,specificity,and predictive values.Cohen
Kappa value was used to quantify the method agreement and Bland Altman test was used to assess the bias and limits of
agreement.Correlation between microscopy and qPCR parasite densities was determined by the Spearman's rank test.
Statistical significance was taken at p<0.05.
Results: A higher sensitivity and a lower specificity were observed in all the three plasmodium species in non 18SrRNA-qPCR compared to 18S-rRNA-qPCR. The sensitivity and specificity of 18S-rRNA-qPCR was 91.3% and 75% in
detection of P.falciparum,67.6% and 88.1% in detection of P.malariae,and 55.8% and 91.4% in detection of P.ovale.The
sensitivity and specificity of non 18S-rRNA-qPCR was 99.1% and 66.7% in detection of P.falciparum,77.9% and 88.1% in
detection of P. malariae, and 79.4% and 90.3% in detection of P. ovale. All the positive and negative predictive values
were above 70% except the negative predictive value for 18S-rRNA-qPCR (47.4%).Kappa of more than 0.5 was observed
between microscopy and both18S-rRNA-qPCR and non-18S-rRNA-qPCR in the detection of all three malaria parasites.
The non-18S-rRNA-qPCR method had higher kappa > 0.65,in all the three species compared to 18S-rRNA-qPCR method
(kappa < 0.55).There was a clear positive correlation between microscopy parasite density and the parasite densities
estimated by the 18S-rRNA-qPCR and Non-18S-rRNA-qPCR (P<0.001).
Conclusion: The results showed that both monoplex realtime PCR methods demonstrated a high performance
compared to microscopy proving to be better methods in the identification and speciation of malaria parasites
especially of low parasitemia.The realtime PCR methods also had a positive correlation with parasite density and hence
can be used in accurate determination of parasite densities when compared to microscopy. Therefore, this study
recommends the utilization of realtime PCR methods in the detection,speciation and quantification of both microscopic
and submicroscopic malaria parasites.
COVID-19 IMPACT ON MEANINGFULNESS OF LIFE, QUALITY OF LIFE AND PSYCHOLOGICAL IMMUNITY
Authors: Kreitler Shulamith , Badarnee Muhammad
Published: May 2022

"The pandemic period of covid-19 has been a time marked by serious declines in quality of life, affecting pervasively not only physical health but also psychological well-being. The purpose of the study was to examine the state and interrelations of the three following variables – quality of life, meaningfulness of life and the psychologically-based physical immunity. It was hypothesized that all three variables will be positively interrelated and that quality of life will fulfill a focal role in this triad of variables. The sample included 230 individuals who responded to an unanimously administered which included the following three questionnaires (all with confirmed satisfactory reliability and validity): the multidimensional quality of life inventory, the meaning-based meaningfulness of life questionnaire, and the cognitive orientation of health questionnaire. The result showed that all three variables were intercorrelated positively. The highest correlations were obtained for quality of life and meaningfulness of life. The cognitive orientation of health appears to be affected more directly by quality of life, and by meaningfulness of life more indirectly through the relation of the latter with quality of life. The impact of covid-19 on the finings was relatively limited. A major conclusion is that that the basic structure of the three variables was maintained preserving their supportive role in the psychological system."
SOCIAL EMOTIONAL LEARNING: DEVELOPING THE ADOLESCENT
Authors: Cipra Alli , Dermer Shannon
Published: May 2022

"During the latter part of the 21st century, social emotional learning (SEL) started being incorporated into the classroom in a meaningful way. While SEL has garnered enough attention to be included in school curricula throughout the United States as well as several other countries worldwide, research about the import and effect of SEL is relatively new (America Succeeds, 2019). The worldwide COVID pandemic has brought about challenges beyond the obvious serious health concerns. Byproducts of the pandemic include the increased need for coping mechanisms and problem solving, interpersonal interaction skills, as well as an understanding of identity development to help children handle emotional distress resulting from the numerous significant changes in their daily lives. However, many current SEL programs do not address these key areas of concern. It is the authors’ contention that an SEL curriculum which focuses on resilience as well as key indicators of identity development, coping mechanisms, and personal de-escalation techniques are necessary to effectively aid adolescents with navigating their current lives and building a positive future. This research proposes a new SEL program that fits the needs of adolescents and preteens as administered in the school system. Building on a previous program shown to significantly improve self-esteem and school cohesion and trust (Cipra & Hall, 2019), Gr2IT focuses on several key principles to help children develop social and emotional skills and resiliency in the classroom and beyond. A unique component of the program is the principle of identity. Because identity formation is a significant developmental task, understanding the reinforcing and bidirectional relation between behavior and identity is beneficial to adolescents. Gr2IT incorporates principles of identity development throughout the curriculum. In conjunction with emotional regulatory practices, problem-solving strategies, and a social equity perspective, Gr2IT introduces a holistic approach to social and emotional learning to support the positive development of youth. While Gr2IT is currently being developed for American schools, many of the principles are universal to child development and may be adapted cross culturally."
STUDENTS PERCEIVED ACADEMIC STRESS, SENSE OF BELONGING, ADAPTABILITY, SPORTS AND DEPRESSION IN THE SECOND YEAR OF THE PANDEMIC
Authors: Feldhammer-Kahr Martina , Arendasy Martin , Paechter Manuela
Published: May 2022

"The COVID-19 pandemic has been challenging for academia. Educators and students hopes for a short duration of the pandemic were disappointed soon and in 2021, one year after the onset of the pandemic, most universities were still restricted to online teaching. At the same time, ensuing restrictions due to COVID-19 coupled with uncertainty about the duration of these adverse circumstances, brought high pressure for many students. Within this background, the present study focuses on the question, to which degree students could develop and use coping mechanisms in these adverse circumstances and draw on personal resources such as sense of belonging, adaptability, and stress-outbalancing behaviors like sports. The aim of this study was to evaluate Austrian students perceived academic stress and was conducted from May to July 2021. Altogether, 202 students, 71 males (35.1%) and 131 females (64.9%) between 18 to 52 years old (M=23.74, SD=5.26) participated. Statistical analyses found significant correlations between perceived academic stress and sense of belonging (socially and organizationally), adaptability, depression, but no significant correlation with sports. In the regression, three variables significantly contributed to the assessment of academic stress. Adaptability and sense of belonging to a peer-group as well as adaptability decreased perceived academic stress. In contrast, depressive symptoms were positively related to academic stress. Altogether, 34.0% of the variance could be explained by the regression equation. Higher levels of perceived academic stress could mostly be explained by a lack of adaptability to the actual situation and sense of belonging to a peer group but a higher amount of perceived depression. These results point at measures that can be taken to alleviate students’ stress. Perceived academic stress and mental-health problems like depressive symptoms should not be taken too lightly, as they do not only concern only individual students, but have consequences for the university as a whole."