bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of Audiolingual Method in Increasing Students' Learning Motivation at Nurul Mun'im Islamic Elementary School
Authors: Hasanah Lailatul Firdaus , Fawaid Achmad
Published: October 2023

The background of this research is motivated by the declining interest of students at MI Nurul Mun'im in learning Arabic. The reason is the lack of interesting learning methods, so there is no motivation for students to follow learning with enthusiasm. Efforts that must be made include the selection of suitable and interesting methods to use that can make learning easier to understand and not cause boredom when teaching and learning activities take place in the classroom. Therefore, researchers chose the audiolingual method as a method of learning Arabic in this study. The audiolingual method means listening and then speaking so that students not only focus on one understanding but are also expected to be able to repeat what they heard before with no errors. The research method used this time is a method with a qualitative approach of the case study type, which is in accordance with its characteristics, namely a method that is in social research. The data collection techniques include observation, interviews, and documentation. The research results are summarized as follows: Students' interest in learning is also greatly increased, as marked by the enthusiasm of students during class, the enthusiasm of students in participating in learning, and a sense of pleasure and love to learn Arabic. This is certainly inseparable from the role of the teacher who has chosen the audiolingual method as a method of learning Arabic. A good teacher and the selection of methods that are suitable for students will make students play an active role during learning activities.
Analisis Swot Implementasi Tri Pusat Pendidikan Sebagai Model Pendidikan Karakter Religius di Sekolah Dasar
Authors: Jaenudin Jaenudin , Fadllurrahman Fadllurrahman , Firdaus Rizal , Alam Dede Ruba'i Misbahul
Published: October 2023

Penelitian ini bertujuan untuk menganalisis implementasi tri pusat pendidikan sebagai model pendidikan karakter religius di sekolah dasar dengan menganalisis aspek-aspek kekuatan, kelemahan, peluang dan tantangan, agar memudahkan para pengelola pendidikan karakter religius di persekolahan, di masyarakat dan di rumah dalam menjalankan program-programnya. Analisis SWOT dipilih sebab fungsinya sebagai suatu alat analisis yang bertujuan untuk menemukan dan menentukan langkah-langkah strategis dalam suatu program tertentu. Metode penelitian yang digunakan dalam artikel ini ialah mix method concurrent design atau metode campuran concurrent, hal ini dilakukan sebab dalam penelitian ini dilakukan dua pendekatan penelitian, yaitu kualitatif dan kuantitatif. Dalam menganalisis berbagai aspek dalam implementasi tri pusat pendidikan sebagai model pendidikan karakter religius di sekolah dasar peneliti menerapkan analisis data kualitatif dengan menjabarkan aspek-aspek kekuatan, kelemahan, peluang dan tantangan secara kualitatif deskriptif. Sementara dalam menganalisis strategi yang harus diambil dalam implementasi tri pusat pendidikan sebagai model pendidikan karakter religius di sekolah dasar peneliti melakukan analisis data kuantitatif dengan menghitung bobot dan rating setiap aspek kekuatan, kelemahan, peluang dan tantangan sehingga menghasilkan positioning strategi dalam kuadran SWOT. Kajian analisis deskriptif kualitatif SWOT terhadap implementasi tri pusat pendidikan sebagai model pendidikan karakter religius di Sekolah Dasar menemukan strategi SO (strength-opportunity), ST (strenght-threat), WO (weakness-opportunity) dan WT (Weakness-Threat). Analisis kuantitatif SWOT terhadap implementasi tri pusat pendidikan sebagai model pendidikan karakter religius di Sekolah Dasar menemukan bahwa positioning implementasi tri pusat pendidikan sebagai model pendidikan karakter religius di Sekolah Dasar berada pada titik kuadran ke 1, hal ini bermakna kondisi paling menguntungkan sebab sejumlah kekuatan internal yang ada dapat memanfaatkan berbagai peluang eksternal yang ada, sehingga diterapkan strategi agresif.
Implementation Of Vaccination Policy In Cirapuhan Village Selaawi District Garut Regency
Authors: Nurhayati Dwi , Sugardi Adi
Published: October 2023

Vaccination in Cirapuhan Village, Selaawi District, Garut Regency is still not evenly distributed so it can hinder the realization of herd immunity in the context of the Covid-19 pandemic. In this study, researchers used a qualitative method with a descriptive approach with secondary and primary data sources. The results showed the implementation of the Garut Regent's Decree No. 443.2/KEP.1103.DINKES/202 The village task force always coordinated through the group social media, socialized, and mobilized the community of the Cirapuhan Village Covid-19 task force. However, the implementation of Garut Regent Decree No. 443.2/KEP.1103.DINKES/202 to achieve herd immunity has not been realized optimally because some people refuse to be vaccinated for fear of side effects and there is an assumption that people do not need vaccination. Based on the results, it can be concluded that the implementation of the Garut Regent's Decree Number 443.2/KEP.1103.DINKES/202 in Cirapuhan Village is still not optimal for the realization of Herd Immunity because the vaccination target in Cirapuhan Village is still many people who refuse to be vaccinated.
Analyze Netizen Sentiment on the Shopee Application
Authors: Emilia Vernanda Denica
Published: October 2023

Internet users in Indonesia continue to grow yearly, with the number of users in 2020 reaching 160 million. Most people access social media, primarily buying and selling e-commerce platforms. Based on data from the Play Store in 2020, Shopee is ranked first as the most frequently used e-commerce application. Seeing this phenomenon, a goal was formed to examine the sentiment of netizens towards the Shopee application. Researchers chose qualitative methods with extensive data analysis assisted by NVIVO applications to achieve this goal. This study uses secondary data by looking at the research unit in the form of comments in the application comment column on Google Play by text mining. The results of this study are that 52.39% of Shopee users give negative comments, 41.26% positive comments, and 6.35% neutral comments, so it can be concluded that Shopee still has many shortcomings that must be corrected to provide the best service to the user community.

Keyword: Netizen sentiment; big data; text mining
FUNCTIONAL ASPECTS OF THE MARKETING MANAGEMENT SYSTEM OF CONSTRUCTION ENTERPRISES
Authors: Максим’юк Ю. C. , Шевчук К. І.
Published: October 2023

The work is devoted to the problem of formation and development of marketing in Ukraine. To reveal the eight stages of the marketing market, under the process of enterprise marketing management analysis, planning, implementation and supervision of activities that have a program, strengthen and promote beneficial exchange with targeted purchases.Based on the conducted research, it can be concluded that theoretical approaches to the formation of management of marketing activities of enterprises continue their development in the work of scientists. The central place in this issue is occupied by management functions: planning, organization and control of marketing activities of economic entities.It is clear that real estate requires significant financial resources, and geomarketing helps developers allocate their budgets more effectively by identifying areas with high potential, conducting personalized marketing activities tailored to specific areas of a city or region or demographic group, increasing the relevance of messages for buyer results or future ones. tenantsAn assessment of the riskiness of construction in the regional markets of Ukraine was carried out. There are three levels of risk. Seven regions have the highest degree of risk (Zaporizhia, Kirovohrad, Mykolaiv, Sumy, Kharkiv, Kherson, Chernihiv regions). Vinnytsia, Zakarpattia, Ivano-Frankivsk, and Lviv regions can be classified as regions with a certain high level of risk, where the recovery has already begun, which has worsened both the increase in real estate prices and the recovery of most of the objects. Other regions are in the zone of comparative risk, it is expected that the drop in sales volumes here will be from 74% in the city of Kyiv to 99% in the Rivne region. If the development company already has facilities for these purposes, then it is possible to recommend the restoration and the implementation of stimulating requests for marketing activities, and if the construction of the facilities is only planned, then a thorough market study and risk assessment should be carried out.The proposed indicators can provide construction enterprises with a comprehensive understanding of the effectiveness of their marketing activities. Adapting the choice of indicators to the specific goals and strategies of the enterprise is crucial for accurate performance diagnosis and continuous improvement
3D bioprinting-based single liver tumor spheroid analysis for aflatoxin B1-induced drug-resistant cancer cell
Authors: Cao Viet Phuong , Hong Sera , Myong Song Joon
Published: October 2023

Aflatoxin B1, found in a variety of foods, is a mycotoxin known to cause cancer. Therefore, humans may be exposed to it through their daily diet. In this study, a three-dimensional (3D) tumor spheroid model was developed via 3D bioprinting to examine whether exposure of HepG2 liver tumor spheroids to aflatoxin B1 can increase the population of drug-resistant liver cancer cells in a single tumor spheroid. Two biomarkers, CD133 (prominin-1) and aldehyde dehydrogenase 1 (ALDH1), were used to identify drug-resistant cancer cells formed in the single liver tumor spheroids. The induction of drug-resistant cancer cells in the single tumor spheroids was examined through single spheroid imaging and fluorescence-activated cell sorting (FACS). The increase of drug-resistant cancer cells, which was caused by aflatoxin B1 in a dose-dependent manner, was quantitatively monitored at the single tumor spheroid level using both methods. 3D bioprinting-fabricated single liver tumor spheroid model successfully determined drug-resistant liver cancer cells caused by aflatoxin B1
Biomimetic 3D bioprinting approaches to engineer the tumor microenvironment
Authors: Bini Fabiano , D’Alessandro Salvatore , Agarwal Tarun , Marciano Daniele , Duchi Serena , Lucarelli Enrico , Ruocco Giancarlo , Marinozzi Franco , Cidonio Gianluca
Published: October 2023

With the increasing incidence and mortality rates, cancer remains a major health challenge in the world. Despite advances in therapies and clinical programs, the efficacy of anti-cancer drugs often fails to translate from pre-clinical models to patient clinical trials. To date, pre-clinical cancer models, including two-dimensional cell cultures and animal models, have limited versatility and accuracy in recapitulating the complexity of human cancer. To address these limitations, a growing focus has fostered the development of three-dimensional (3D) tumor models that closely resemble the in vivo tumor microenvironment and heterogeneity. Recent efforts have leveraged bioengineering technologies, such as biofabrication, to engineer new platforms that mimic healthy and diseased organs, aiming to overcome the shortcomings of conventional models, such as for musculoskeletal tissues. Notably, 3D bioprinting has emerged as a powerful tool in cancer research, offering precise control over cell and biomaterial deposition to fabricate architecturally complex and reproducible functional models. The following review underscores the urgent need for more accurate and relevant 3D tumor models, highlighting the advantages of the use of biofabrication approaches to engineer new biomimetics platforms. We provide an updated discussion on the role of bioengineering technologies in cancer research and modeling with particular focus on 3D bioprinting platforms, as well as a close view on biomaterial inks and 3D bioprinting technologies employed in cancer modeling. Further insights into the 3D bioprinting tissue-specific modeling panorama are presented in this paper, offering a comprehensive overview of the new possibilities for cancer study and drug discovery.
 
Advancements in biomaterials and biofabrication for enhancing islet transplantation
Authors: Kang Dayoon , Kim Jaewook , Jang Jinah
Published: October 2023

Type 1 diabetes (T1D) is characterized by the degeneration of insulin-producing beta cells within pancreatic islets, resulting in impaired endogenous insulin synthesis, which necessitates exogenous insulin therapy. Although intensive insulin therapy has been effective in many patients, a subset of individuals with unstable T1D encounter challenges in maintaining optimal glycemic control through insulin injections. Pancreatic islet transplantation has emerged as a promising therapeutic alternative for such patients, offering enhanced glucose regulation, reduced risk of complications, and liberation from exogenous insulin reliance. However, impediments such as immune rejection and the need for an optimal transplantation environment limit the success of islet transplantation. Revascularization, a crucial requirement for proper islet functionality, poses a challenge in transplantation settings. Biomaterial-based biofabrication approaches have attracted considerable attention to address these challenges. Biomaterials engineered to emulate the native extracellular matrix provide a supportive environment for islet viability and functionality. This review article presents the recent advancements in biomaterials and biofabrication technologies aimed at engineering cell delivery systems to enhance the efficacy of islet transplantation. Immune protection and vascularization strategies are discussed, key biomaterials employed in islet transplantation are highlighted, and various biofabrication techniques, including electrospinning, microfabrication, and bioprinting, are explored. Furthermore, the future directions and challenges in the field of cell delivery systems for islet transplantation are discussed. The integration of appropriate biomaterials and biofabrication methods has significant potential to promote successful islet transplantation by facilitating vascularization and bolstering the immune defense mechanisms.
Multiscale 3D bioprinting for the recapitulation of lung tissue
Authors: Fan Pengbei , Jin Fanli , Qin Yanqin , Wu Yuanyuan , Yang Qingzhen , Liu Han , Li Jiansheng
Published: October 2023

Lung tissue engineering (LTE) has gained significant attention as a highly promising and innovative strategy to tackle the formidable obstacles posed by lung-related diseases and the lack of compatible donor organs availability. In the realm of groundbreaking advancements in tissue engineering (TE), one particular technology that has emerged as a game-changer is three-dimensional (3D) bioprinting. It distinguishes itself by offering a potent and versatile approach to constructing intricate structures while opening up new horizons for TE and regenerative medicine (RM). This review focuses on the application of multiscale 3D bioprinting techniques in LTE and the reconstitution of lung tissue in vitro. We analyzed the key aspects such as bioink formulations and printing strategies utilized from macroscale 3D bioprinting to micro/nanoscale 3D bioprinting. Additionally, we evaluated the potential of multiscale bioprinting to replicate the complex architecture of the lung, ranging from macrostructures to micro/nanoscale features. We discussed the challenges and future directions in biofabrication approaches for LTE. Furthermore, we highlight the current progress and future perspectives in tissue reconstitution of lung in vitro, considering factors such as cell source, functionalization, and integration of physiological cues. Overall, multiscale 3D bioprinting offers exciting possibilities for the development of functional lung tissues, enabling disease modeling, new drug screening, and personalized regenerative therapies.
 
 
MONUMENTS OF THE RUSSIAN PRESENCE IN TIANJIN
Authors: KHISAMUTDINOV AMIR , LI YAN
Published: October 2023

The article is devoted to the material heritage of modern Tianjin, concerning the Russian community in the first half of the 20th century. This concept refers to buildings closely associated with the political, financial, creative, entertainment and religious activities of immigrants from Russia: Russian Consulate, Russian-Asian Bank, Jewish Synagogue, Victoria Cafe and Capitol cinema. The publication uses rare emigrant publications, articles by Chinese researchers, as well as the results of field research in Tianjin (2010-2021).
FEATURES OF FEMALE HEROIC IMAGES IN CHINESE FOLK OPERA
Authors: GUAN CHENGYUAN
Published: October 2023

The article discusses the features of the embodiment of female heroic images in Chinese folk operas on a military-patriotic theme. The material for the analysis was the images of Sister Jiang (opera “Sister Jiang”, 1964), Tian Yumei (opera “Daughters of the Party”, 1991) and Haitang (opera “The Yimenshan Mountains”, 2018). One of the objectives of the study is to identify the dynamics of development of this type of hero in the genre of Chinese folk opera. The article emphasizes that the heroic image of a woman is important for Chinese culture and is associated with the feminist movement in the first half of the 20th century. The analysis of the operas showed similarities and differences in the dramatic role and in the musical characteristics of Sister Jiang, Tian Yumei and Haitan. They have a similar experience of fighting the enemy, they are ready to sacrifice themselves for the common good. In their vocal parts, “central songs” are carried out, the most important part of their musical characteristics are large monologue arias. The differences are related to the level of psychological credibility of these characters. The example of Sister Jiang, Tian Yumei and Haitan clearly shows the trend towards a gradual increase in Chinese folk operas of elements of femininity and psychologism. This trend is manifested in an increase in the number of vocal numbers with episodes of a subjective-lyrical nature that reflect the feelings of the heroines and their state of mind.
Emociones y metas académicas: diferencias de género en alumnado de Formación Profesional
Authors: Pérez-Martín Sabela , Frieiro Padín Paula , Riobóo-Lois Breogán
Published: October 2023

Esta investigación tiene como objetivo analizar las diferencias de género en las metas y emociones académicas como factores motivacionales fundamentales en el proceso de autorregulación. Participaron 111 estudiantes de Formación Profesional en Galicia a través del cuestionario Achivement Emotions Questionnaire y las Escalas de Estrategias Motivacionales del Aprendizaje - Versión Secundaria. Los resultados indican que las mujeres de la muestra tienen mayor tendencia en enfocar sus metas en la autoderrota del ego y presentan un mayor nivel de ansiedad en relación al estudio que los hombres. Finalmente, a partir de los hallazgos, se estima que analizar el género es relevante para los estudios educativos sobre emociones y metas académicas.
COVID-19 ir miokarditas. Ko mus išmokė pandemija?
Authors: Baldauskaitė Gabija , Biesevičienė Monika , Vaitiekienė Audronė , Šakalytė Gintarė , Plisienė Jurgita
Published: October 2023

Tyrimo tikslas. Įvertinti COVID-19 ligos įtaką dėl miokardito, mioperikardito, perimiokardito hospitalizuojamų pacientų skaičiui, ligų dažniui, lyginant su iki pandemijos buvusiu hospitalizavimu. Tyrimo metodai. Retrospektyvusis tyrimas vyko Lietuvos sveikatos mokslų universiteto ligoninės Kauno klinikų (toliau – Kauno klinikų) Kardiologijos klinikoje. Į tyrimą įtraukti 55 pacientai, gydyti 2018–2021 m. dėl miokardito, mioperikardito, perimiokardito. Hipotezėms tikrinti apskaičiuoti chi kvadrato (χ2), Stjudento (t), Mano-Vitnio kriterijai. Skirtumai laikyti statistiškai reikšmingais, kai p < 0,05. Rezultatai. 2018–2019 m. dėl miokardito, mioperikardito ir perimiokardito hospitalizuoti 26 pacientai, per COVID-19 pandemiją – 29 pacientai. Tyrimo populiacijoje dominavo vyrai, o moterys sudarė 11 proc. Sirgo jauni asmenys (amžiaus vidurkis – 35 metai). Moterys, sirgusios uždegiminėmis miokardo ligomis, buvo vyresnio amžiaus, turėjo mažesnę kairiojo skilvelio išstūmio frakciją (KS IF) ir ilgesnį laiką praleido stacionare (p < 0,05). Su COVID-19 susijusi anamnezė – 12 asmenų. 81,8 proc. tiriamųjų pagrindinis simptomas – stiprus krūtinės skausmas. Ikipandeminėje grupėje elektrokardiogramose (EKG) dominavo (61,5 proc.) konkavinis ST segmento pakilimas, o pandeminėje grupėje jis pasireiškė 25 proc. pacientų (p < 0,05). Iki pandemijos statistiškai dažniau skirti nesteroidiniai vaistai nuo uždegimo (NVNU); jais dažniau gydyti jaunesnio amžiaus pacientai, kurių KS IF normali, nustatyta didesnė C reaktyviojo baltymo (CRB) ir troponino koncentracija (p < 0,05). Išvados. Pacientų, hospitalizuotų dėl miokardito, mioperikardito, perimiokardito, skaičius per koronaviruso sukeltą pandemiją išaugo 11,5 proc. Dažniausiai sirgo jauni vyrai. Sirgusios moterys buvo vyresnės, turėjo mažesnę KS IF ir ilgesnį laiką praleido stacionare. Miokarditų eiga reikšmingai nesiskyrė ikipandeminiu ir pandeminiu laikotarpiais, tačiau persirgimas COVID-19 liga ir vakcinacija buvo susiję su 41,4 proc. miokarditų 2020–2021 m. laikotarpiu. Per pandemiją EKG 4,92 karto dažniau nustatyti ritmo sutrikimai ir T dantelio pokyčiai, tačiau gydymui 2,03 karto rečiau skirti NVNU.
Hipotiroidizmas bei širdies ir kraujagyslių ligos. Jų sąsajos ir gydymo savitumai
Authors: Gelčytė Urtė , Svirplytė-Burakauskienė Gabrielė , Rapalavičius Aurimas
Published: October 2023

Širdies ir kraujagyslių ligos (ŠKL) – tai didelė ligų grupė ir pagrindinė ligų bei mirties priežastis pasaulyje. Dažniausios ligos formos yra arterinė hipertenzija, širdies nepakankamumas, išeminė širdies liga, miokardo infarktas bei galvos smegenų insultas. Daugumos širdies ir kraujagyslių ligų galima išvengti, todėl būtina suprasti šių ligų atsiradimo veiksnius. Vienas iš jų – skydliaukės hormonai. Jie yra itin svarbūs normaliai širdies ir kraujagyslių sistemos veiklai, todėl šio tyrimo tikslas – atlikti naujausios mokslinės literatūros apžvalgą apie širdies ir kraujagyslių sistemos bei hipotiroidizmo sąsąjas ir jo gydymo savitumus širdies ir kraujagyslių sistemai. Mokslinės literatūros apžvalgos planavimo ir duomenų analizės bei aptarimo metu vadovautasi PRISMA kriterijais. Literatūros paieška atlikta naudojantis LSMU virtualiosios bibliotekos prieiga prie elektroninio žurnalo „PubMed“. Iš viso atrinkta ir išanalizuota 19 publikacijų, paskelbtų 2017–2022 m. laikotarpiu. Tyrimo rezultatai parodė, kad skydliaukės hormonai moduliuoja kiekvieną širdies ir kraujagyslių sistemos komponentą, būtiną normaliai širdies ir kraujagyslių sistemos veiklai. Skydliaukės funkcija veikia širdies kontraktiliškumą, minutinį širdies tūrį, arterinį kraujospūdį, sisteminį kraujagyslių pasipriešinimą bei lemia normochrominę normocitinę anemiją ir dislipidemiją. Taip pat skydliaukės disfunkcija gali sukelti sunkių širdies komplikacijų, tokių kaip aritmijos arba širdies nepakankamumas, o jų gydymui reikia kontroliuoti pagrindinį skydliaukės hormono kiekį. Sprendžiant iš klinikinių tyrimų, kuriuose buvo įvertintas ryšys tarp skydliaukės hormonų bei ŠKL rizikos veiksnių, galima daryti išvadą, kad pacientams, kuriems reikia gydyti skydliaukės disfunkciją ir sergantiems sunkia širdies ir kraujagyslių liga, itin didelis dėmesys turi būti skiriamas ne tik pagrindinių sutrikimų valdymui, bet ir hipotiroidizmo korekcijai levotiroksinu. Teisingai nustačius diagnozę, normalizavus skydliaukės funkciją, daugeliu atvejų regresuoja ŠKL simptomai arba jie tampa lengviau kontroliuojami, todėl svarbu skirti individualų gydymą, atsižvelgiant į paciento amžių bei jo gretutines ligas.
Probiotikų reikšmė periodonto ligų profilaktikoje ir gydyme
Authors: Michnevičienė Kornelija , Jagelavičienė Eglė , Zūbienė Jūratė
Published: October 2023

Periodonto ligos – įvairaus amžiaus grupėse plačiausiai paplitusios burnos ertmės ligos, kurios pažeidžia periodonto audinių struktūras, sukelia burnos funkcinius sutrikimus, dantų netekimą, padidina širdies ir kraujagyslių sistemos bei daugelio kitų ligų riziką. Siekiant išvengti periodonto ligų, nuolat ieškoma naujų gydymo ir profilaktikos galimybių. Augant organizmo atsparumui antibiotikams, pradėtas taikyti naujas periodonto ligų gydymo ir profilaktikos metodas – probiotikų terapija.
Atnaujintos vitamino D stygiaus diagnostikos, profilaktikos ir gydymo gairės
Authors: Lietuvos šeimos gydytojų kolegija
Published: October 2023

Kelis pastaruosius dešimtmečius vitaminas D bei jo poveikis organizmui plačiai tyrinėjamas. Žinoma, kad šis vitaminas svarbus ne tik kalcio ir fosforo apykaitai, bet ir tinkamai imuninės sistemos ir kitų organų bei sistemų veiklai [1–12]. Visuotinai pripažįstama, kad daugeliui šalių, tarp jų ir Lietuvai, vis dar aktuali nepakankamo aprūpinimo vitaminu D problema [14–16]. Egzistuoja daug įvairių lygmenų (šalies, regiono, tarptautinių) vitamino D stygiaus diagnostikos, gydymo bei profilaktikos rekomendacijų. Deja, Lietuvoje iki šiol nacionalinių rekomendacijų (arba gairių) šiuo klausimu nesukurta. Visa tai paskatino parengti šias naujas, originalias, praktines vitamino D stygiaus diagnostikos, profilaktikos ir gydymo rekomendacijas. Šių gairių esmė – vitamino D įvairiapusio poveikio pripažinimas ir „atsargiai didesnių“ vitamino D dozių rekomendavimas. Šios gairės naudingos Lietuvos gydytojų (ypač šeimos) kasdieniame darbe, taip pat medicinos studentams, rezidentams.
Biologiškai aktyvūs maisto komponentai ir sveikas senėjimas
Authors: Serapinas Danielius
Published: October 2023

Su amžiumi susijusios ligos šiuolaikinėje medicinoje tampa vis aktualesne problema. Senėjimas ne tik didina lėtinių somatinių ligų, bet ir onkologinių ligų riziką. 2021 m. 80 proc. visų vėžio atvejų Jungtinėse Amerikos Valstijose buvo diagnozuoti 55 metų ir vyresniems asmenims. Mitybos reguliavimas yra vienas iš šios problemos sprendimo būdų. Subalansuota dieta aprūpina organizmą maisto medžiagomis, vitaminais ir mineralais, kurie reikalingi sveikai organizmo būsenai. Egzistuoja specifinės maistinės medžiagos, tokios kaip spermidinas, kurios gali atkurti pažeistus ląstelių procesus bei skatinti ilgaamžiškumą. Šios medžiagos sulaukė ypatingo mokslininkų dėmesio dėl įtakos lėtinant senėjimą per metabolinius bei telomerų apsaugos mechanizmus.
Plonojo žarnyno bakterijų išvešėjimo sindromas ir gyvensenos medicinos intervencijos
Authors: Balčiūnienė Eglė
Published: October 2023

Plonojo žarnyno bakterijų išvešėjimo sindromas (SIBO) apibrėžiamas kaip per didelis bakterijų kiekis plonajame žarnyne, kuris sukelia įvairius virškinamojo traktosutrikimus. SIBO sukelia padidėjusį žarnyno pralaidumą, todėl atsiranda maistinių medžiagų malabsorbcija (dažniausiai pastebimas vitamino D, vitamino B12 ir geležies stygius). Atlikti tyrimai rodo, kad net iki 50 proc. žmonių, sergančių dirgliosios žarnos sindromu, turi SIBO. SIBO gydomas vaistais ir gyvensenos veiksnių korekcija. Tyrimai rodo, kad eliminacinės dietos (kitaip – elementinė, FODMAP, begliutenė dietos) yra veiksmingos gydant disbiozę ir kontroliuojant varginančių virškinamojo trakto sutrikimų atsiradimą.
ДЕМАРКАЦИЯ МЫСЛИТЕЛЬНОЙ ДЕЯТЕЛЬНОСТИ И ПРОЦЕССА МЫШЛЕНИЯ
Authors: Евдокимов В.Н.
Published: October 2023

В статье рассматриваются различия таких явлений как мыслительная деятельность и процесс мышления. Специфицируются такие понятия как «процесс» и «деятельность» для более ясного понимания сущности рассматриваемых явлений.
Flow Visualization on Submerged Flow Conditions in Open Channel Weir Downstream
Authors: Siti Natasha Malik Fesal  , Mas Fawzi  , Mohd Azahari Razali  , Juntakan Taweekun
Published: October 2023

Submerged flow regimes are common phenomena observed in open channel flow, such as rivers and spillways, with or without weirs. These flow regimes involve a sudden rise in the liquid surface downstream when high-velocity liquid discharges into a region of lower velocity. The rapid deceleration of the flowing liquid results in an increase in height and a conversion of kinetic energy into potential energy, with some energy dissipated as turbulence and heat. In this study, flow visualization techniques were employed to investigate the two-dimensional hydrodynamic characteristics of submerged hydraulic jumps within the Froude number range of 1.0 to 5.4 over a fixed bed. The obtained results were compared with existing literature data, showing a good agreement. This research contributes to the understanding of submerged flow phenomena and provides valuable insights into the hydrodynamics of submerged hydraulic jumps.
The Effect of Temperature on the 3D printed Mold Using Polyethylene terephthalate glycol (PETG), Polylactic Acid (PLA) and Stereolithography (SLA)
Authors: Ahmad Arsyad Mohd Noordin  , Norhafizah Burham  , Tuan Norjihan Tuan Yaakub  , Anees Abdul Aziz  , Marianah Masrie
Published: October 2023

The usage of 3D printing technology is explored in biomedical applications, specifically for drug delivery systems or cell separation using microfluidic channels. The fabrication of a 3D mold is very crucial, especially for fabricating a Polydimethylsiloxane (PDMS) microfluidic channel. This paper highlights the effect of temperature on the mold using different material elements, which is filament and resin, for fabricating a PDMS microfluidic channel. The mold structure was observed, and the mold was tested by repeating the process ten times. The molds were pre-heated, and the result shows that the structure of PLA mold gives the highest increases in sizing compared to PETG and SLA. The PDMS microchannel fabricated using 3D mold also shows the same result. The sizing of the PDMS microchannel increased linearly as it was tested five times with the same procedure. The mold was successfully fabricated with different materials, and the PDMS microchannel was successfully fabricated using the 3D-printed mold.
Experimental Study on Thermo-Physical Properties of TiO2-SiO2 Nanofluids (70:30) in Water/Ethylene Glycol Mixture
Authors: Mohd Amiruddin Fikri  , Wan Mohd Faizal  , Hasyiya Karimah Adli  , Rizalman Mamat  , Wan Hamzah Azmi  , Anwar Ilmar Ramadhan
Published: October 2023

Nanofluid is a solid particle that does not have a larger size than the 100 nm diffusion in the liquid. Its use can improve the nanofluids properties versus base fluid. More recently, many researchers are keen to know more about the combination of nanoparticles either two or more because of its effect to increase heat transfer in liquid heat. Thus, preparations between Silica (SiO2) and Titania (TiO2) in water (W) and ethylene glycol (EG) were carried out experimentally in volume concentrations between 0.3 and 1% and temperatures between 30-70 °C and 60:40 (Water: EG); 70:30 (TiO2-SiO2) with one step method. Thermal conductivity is measured by heat and viscosity method with viscometer equipment. Thermal conductivity results show that the increase with different temperatures. However, dynamic viscosity decreases with different temperatures. Studies show that hybrid nanofluids between SiO2 and TiO2 have an excellent thermal conductivity at a volume of 1.0% and a temperature of 70 °C indicating a right combination of nanofluid TiO2-SiO2.
Numerical Analysis of Recycled AA6061 Reinforced Alumina Oxide Undergoing Finite Strain Deformation Uniaxial Tensile and Taylor Cylinder Impact Tests
Authors: Norzarina Ma'at  , Mohd Khir Mohd Nor
Published: October 2023

Recycling aluminum is a topic of high interest due to the global demand for aluminum-based products. This approach presents a great opportunity to address the environmental issues caused by the primary production of aluminum made from bauxite ore. In recent years, many researchers have explored the recycling of aluminum alloys, including reinforcement, to achieve better results and improve properties. However, there have been limited efforts to predict the deformation behaviour of such materials numerically. It is generally agreed that advancements in numerical analysis are important to accelerate progress and establish the application of newly developed materials. Therefore, this study aimed to numerically predict the deformation behaviour of recycled aluminum alloy AA6061 reinforced with Alumina Oxide, subjected to finite strain deformation of uniaxial tensile tests at different strain rates (6x10-1s-1 to 6x10-3s-1) and Taylor Cylinder Impact at different impact velocities (190ms-1 to 370ms-1) using the LS-DYNA simulation code. In this numerical analysis, a Simplified Johnson-Cook model is adopted and characterized. The simulation results, which were validated against published experimental data, showed good agreement, establishing appropriate numerical prediction capabilities for recycled aluminum alloys AA6061 reinforced with Alumina Oxide.
Numerical Analysis on the Flow Depth Behaviour in Dividing Open-Channel for Trapezoidal and Rectangular Cross-Sectional Channel
Authors: Puteri Nadia Shafiqah Harmizi  , Siti Aimi Asyarah Zakaria  , Iskandar Shah Mohd Zawawi  , Mohd Ridza Mohd Haniffah
Published: October 2023

Open-channel with dividing flow refers to any side water withdrawals from streams, rivers or main channel. It has become an important issue, especially when measuring the flow rate and depth of water as part of environmental management schemes and many practical projects such as the system of irrigation and drainage, water and wastewater treatment plants and other water resources projects. Although the behaviour of water flow has been studied by the previous researchers, most studies have only been carried out in simulation and lab experiment for a straight prismatic main channel. The mathematical research has not yet been fully understood, particularly in relation to the behaviour of water flow. Therefore, in this study, the modified general equations of dividing open-channel flow for rectangular and trapezoidal in the form of non-linear polynomial equations are proposed to determine the upstream flow depth in rectangular and trapezoidal cross-sectional channel. The computations of water flow depth influenced by Froude number and discharge ratio are performed with Newton-Raphson procedure in Maple software. The numerical solution shows the good agreement with the experimental data as reported in the literature. When the discharge ratio is low, the flow depth in trapezoidal and rectangular channels exhibits similarity. However, as the discharge ratio increases, the flow depth in the rectangular channel surpasses that in the trapezoidal channel. Furthermore, as the Froude number increases, the rectangular channel experiences a greater flow depth in comparison to the trapezoidal channel.
Strategi Pemimpin dalam Memperkuat Kekompakan Karyawan pada Budiman Swalayan Padang, Air Tawar
Authors: Zharifa Zena , Syamsir Syamsir , Susanti Desi , Rahmawati Fany , Rahma Fari , Pratama Haikal
Published: October 2023

Organisasi pegawai pada Supermarket Budiman yang muncul ditandai dengan tidak adanya pegawai pada area produk atau rak pada setiap lorong. Karyawan hanya tinggal di satu lorong atau satu area produk, ada juga yang harus berdiri di lorong atau rak produk lain untuk melayani konsumen yang ingin bertanya tentang keberadaan produk dengan merek lain, kualitas produk, atau barang terbaik dari beberapa produk. sama dengan merek yang berbeda. Dalam penelitian kami menggunakan metode penelitian kualitatif yaitu teknik wawancara dan observasi untuk mencari data dan mengetahui penyebab perselisihan karyawan dan strategi pimpinan. Ketidakpatuhan pegawai timbul karena kurangnya kesadaran akan tanggung jawab terhadap tugas yang diberikan. Untuk itu dalam memperkuat kekompakan pegawai, pemimpin harus mampu menjalankan strategi dengan menciptakan alur komunikasi yang efektif, serta menjadi pemimpin yang direktif untuk selalu mengarahkan pegawai dalam organisasi agar mematuhi aturan-aturan yang ditetapkan dalam suatu organisasi.
Microbial Impacts on Colloid-Radionuclide Interactions
Authors: Morgan Chloe , Byrd Natalie , Robinson Callum , Lopez-Odriozola Laura , Woodall Sean , Shaw Samuel , Natrajan Louise , Morris Katherine , Lloyd Jonathan
Published: October 2023

Microorganisms can play an important role on the behaviour of colloids in natural and engineered environments, which in turn can control the mobility of associated metals and radionuclides. This is especially true in the nuclear fuel cycle, where radionuclides (including uranium) can interact with a broad range of inorganic colloids. This is relevant to the legacy spent nuclear fuel ponds at Sellafield, which house a diverse inventory of waste from the early Magnox reactors. These reactors used uranium metal as a fuel encased in a magnesium non-oxide cladding. Corrosion of the cladding results in the release of radionuclides, primarily uranium, and the formation of brucite (Mg(OH)2) phases which are present both in the corroded Magnox sludge at the base of the pond and suspended in the water column as colloids (Gregson et al. 2011). These brucite colloids have the potential to mobilise insoluble phases providing an important pathway for radionuclide migration. The spent nuclear fuel ponds are maintained at high pH to minimise corrosion of the cladding, however significant corrosion has still occurred.

Despite the seemingly inhospitable conditions in spent nuclear fuel ponds, numerous studies have found microorganisms capable of surviving in spent nuclear fuel ponds (Dekker et al. 2014, Foster et al. 2020, Ruiz-Lopez et al. 2020). Previous work has demonstrated increased abiotic sorption of strontium to brucite in the presence of organic matter derived from Pseudanabaena catenata (Ashworth et al. 2018), which dominates algal blooms in the ponds. In this study we focus on uranium interactions with colloidal brucite in the presence of microbes adapted to high pH environments under conditions relevant to the spent nuclear fuel ponds at Sellafield.
Anaerobic Isoprene-Degrading Microorganisms and their Impact on Microbial Methane Dynamics in Deep-Sea Carbonates and Eucalyptus-Leaf Sediments
Authors: Giri Samikshya , Prouty Nancy , Beckmann Sabrina
Published: October 2023

Isoprene, a highly abundant biogenic volatile organic compound, has emerged as a crucial yet overlooked factor in addressing climate change. Despite its widespread production in all forms of life, comprehensive data on its global biogeochemical cycle remain scarce. Isoprene's reactivity in the atmosphere influences methane concentrations, with detrimental implications for climate, air quality, and health. Conversely, methane is abundant in marine and terrestrial subsurface environments, where deep-sea carbonates serve as hotspots for microorganisms performing anaerobic methane oxidation—an essential process in long-term methane storage and removal from the marine carbon cycle. Recent studies by Beckmann et al. (2020), Prouty et al. (2020) have shed light on novel metabolic pathways utilized by microbial communities in carbonates for methane oxidation. Similarly, in terrestrial environments, eucalyptus trees, as the highest emitters of isoprene, may harbor microorganisms capable of metabolizing isoprene alongside methane-oxidation and formation in eukalyptus leaf detritus. However, little is known about the fate of isoprene and the potential microbial communities involved in its metabolism within deep-sea carbonates and eucalyptus-leaf sediments, potentially impacting methane metabolism. Our study aims to unravel the anaerobic pathways of microbial isoprene degradation and investigate the effects of isoprene abundance and degradation on microbial methane production and oxidation. We detected anaerobic isoprene-degradation in deep-sea carbonates and terrestrial eukalyptus-leave sediments, where methane oxidation and methane formation was pronounced. Surprisingly, the presence of isoprene inhibited mcirobial methane-oxidation as well as methane-formation, suggesting an substantial impact of the presence of isoprene on methane cycling and storage. We are currently characterizing and isolating the microorganisms involved in the isoprene and methane metabolism in these enrichment cultures.
Application of geomicrobial techniques to constrain mechanisms of arsenic mobilisation in anoxic aquifers
Authors: Seitshiro Teto , Bassil Naji , Moore Oliver , Lloyd Jonathan
Published: October 2023

Geogenic arsenic contamination of groundwater in South and South-East Asia poses a significant human health threat, causing a range of health conditions including but not limited to cardio-vascular disease, cancer and skin lesions (Argos et al. 2010, Pienkowska et al. 2021). Arsenic contamination also hosts a range of dire socioeconomic implications for the affected areas. A variety of mechanisms for arsenic release in anoxic aquifers have been proposed, however, the most widely accepted mechanism is the microbial reduction of As-bearing Fe(III) (oxyhydr)oxide minerals coupled with the oxidation of organic carbon (Glodowska et al. 2020, Gnanaprakasam et al. 2017). Recent research has implicated methane as a possible carbon source in the reduction of Fe(III) (oxyhydr)oxide minerals and the subsequent release of arsenic into the groundwater (Gnanaprakasam et al. 2017, Pienkowska et al. 2021). The research suggests that methanotrophs have the ability to drive anaerobic oxidation of methane, AOM, coupled to Fe(III) (oxyhydr)oxide reduction. In this study, we aim to provide unequivocal evidence for the occurrence of AOM coupled to Fe(III) (oxyhydr)oxide as well to further explore the exact mechanism(s) involved which is yet to be characterised. Here we present an overview of our work so far.
A current insight and future perspective of edible bird nest as caviar of the east
Authors: Haraharap Muhammad Andika , Sjofjan Osfar , Radiati Lilik Eka , Natsir Muhammad Halim , Abdi Syahputra Rony , Nurkolis Fahrul
Published: October 2023

Edible bird’s nest (EBN) is a highly valuable food product obtained from swiftlet nests, primarily those of the Aerodramus genus. Due to its purported health benefits and exceptional taste, EBN is often referred to as the “caviar of the East.” This abstract presents a comprehensive review of the current state of EBN research, focusing on its chemical composition, nutritional value, pharmacological effects, and safety considerations. The chemical composition of EBN is intricate and influenced by various factors, including bird species, geographic origin, nest collection time, and processing methods. It is primarily composed of proteins, polysaccharides, minerals, lipids, and a wide range of bioactive compounds such as sialic acid, amino acids, and antioxidants. Additionally, EBN has demonstrated antioxidant, anti-inflammatory, anti-tumor, and anti-aging properties attributed to these bioactive constituents. While EBN is generally considered safe for human consumption, it is essential to address concerns related to potential contaminants like heavy metals, microbial pathogens, and allergens. This review offers a comprehensive overview of previous research conducted on residual impurities that may be present in edible bird’s nests (EBNs). The review encompasses various aspects, including, the regulatory framework and associated concerns regarding EBNs, the levels of nitrite and nitrate detected in EBNs, the presence of bacteria, fungi, and mites in EBNs, the identification of allergenic substances in EBNs, and the presence of heavy metals and excessive mineral content at different stages of EBN processing, including raw uncleaned (RUC) EBNs, raw cleaned (RC) EBNs, and EBNs after undergoing treatment.

Graphical abstract:
Toute médaille a son revers : les effets de la mixité des équipes militaires sur l’intensité conflictuelle et la cohésion
Authors: Essig Elena , Soparnot Richard
Published: October 2023

Une littérature conséquente est consacrée aux effets de la mixité au travail sur le fonctionnement des organisations et des équipes. Force est toutefois de constater que la littérature ne fait pas consensus, celle-ci oscillant entre l’existence d’effets positifs ou négatifs, l’absence d’effets et l’existence d’un taux de mixité optimal. Notre recherche s’intéresse donc aux effets du taux de mixité sur l’intensité conflictuelle et la cohésion. Pour ce faire, nous avons réalisé une enquête quantitative et qualitative auprès d’une population de 124 sous-officiers de l’armée de l’air française, répartis en 21 équipes. Les équipes ayant certains taux de mixité affichent ainsi de meilleurs résultats en termes l’intensité conflictuelle et la cohésion d’équipe.
Rapprochement symbiotique d’organismes publics de recherche : contradiction et traduction
Authors: Fernando Julien , Meier Olivier
Published: October 2023

À l’instar de certaines organisations privées, opérant dans des secteurs en mutations rapides, les organismes publics de recherche peuvent envisager de recourir à la croissance externe en vue de renouveler leur paradigme stratégique et construire de nouveaux avantages concurrentiels. Cette manœuvre reposant sur une logique de co-développement, est appréhendée dans la littérature en management de l’intégration post-fusion, à travers la politique de symbiose (Haspeslagh et Jemison, 1991). Si cette approche est souvent considérée comme un mode de développement optimal, elle reste particulièrement complexe en raison des exigences contradictoires qu’elle soulève. Cet article s’appuie sur une étude de cas longitudinale d’une fusion récente pour étudier les conditions d’émergence et de stabilisation d’un tel projet stratégique dans le secteur de la recherche publique. Le modèle de la traduction (Callon, 1986) est mobilisé pour décrypter les mécanismes relationnels visant à faire face aux dilemmes induits par la recherche de symbiose. L’étude montre dans quelle mesure un organisme public de recherche peut parvenir à valoriser les atouts distinctifs d’un partenaire, afin de se renouveler sur le plan scientifique et institutionnel.
Le terrorisme sacrificiel religieux : au carrefour de la radicalité adolescente et du malaise contemporain
Authors: Hirsch Denis
Published: October 2023

Cet article traite des mécanismes intrapsychiques, interpsychiques et collectifs qui aliènent le moi inconscient dans le phénomène du terrorisme radical religieux. S’y intriquent nécessairement la psychologie individuelle et la psychologie collective, comme dans tous processus meurtriers à caractère totalitaire. Prenant en compte la clinique des adolescents en errance identitaire, le texte ouvre un débat sur l’origine fondamentale de toute violence terroriste radicale et sur un profond malaise actuel dans la culture occidentale. L’acte terroriste sacrificiel se situerait au carrefour entre une tentative désespérée de vérifier la survie de l’objet à la destructivité extrême et l’expression d’un masochisme de mort désintriqué. Mais ce phénomène à haute contagiosité nous interroge sur la possible mélancolisation de nos sociétés hypermoderne et néolibérales.