bluuebunny/crossref_metadata_2025 huggingface dataset:
Environmental Regulation, Pollution Emissions and the Current Account
Authors: Zheng Shuang , Liu Xiaohui , Zuo Yihe
Published: May 2023

We develop a dynamic general equilibrium model to explain the impact of environmental regulation, in a form of pollution tax, on the current account. The model predicts that lower pollution tax will increase the output and consumption of tradable goods and the total output, and appreciate the real exchange rate, but have no impact on the output and consumption of nontradable goods. Although the impact of pollution tax on the level of the current account is uncertain, we find that its impact on the current account-total output ratio depends on net foreign asset in the last period. If net foreign asset in the last period is positive, lower pollution tax and consequently more pollution emissions tend to decrease the current account-total output ratio. Otherwise, it will increase the ratio. Empirical evidence from 156 economies (1980–2018) shows a statistically and economically significant negative impact of pollution emissions on the current account-total output ratio when the last period’s net foreign asset is positive. This is especially true for higher-income economies. However, the positive impact is statistically insignificant when the last period’s net foreign asset is negative. In general, empirical evidence is consistent with the model’s prediction. In addition, we also find that the negative impact of pollution emissions on the current account-total output ratio is channeled by the real exchange rate appreciation caused by lower pollution tax.
JEL Classification: F18, F32, Q28
The White Cane Technique: a Skill for Reducing Mobility Dependence for Student With Visual Impairment
Authors: Mensah Prosper Anthony , Agbezudor Theresa , Gyamfi Abraham , Acquaye Rosemary
Published: May 2023

This study was an action research to improve the orientation and mobility skills of a level 100 student with visual impairment at Wesley College of Education, Kumasi, Ghana. The data was collected through the use of interviews and observations. The sample size for the study was one (1) level 100 student with visual impairment. Data collected for the study was represented on tables and descriptively analysed. The results from the interventional strategies revealed an improvement in the performance of the student based on the skills he was taken through. The problem of fine motor skills which were pre-requisite skills needed for the use of the white cane was addressed after the visually impaired student was taken carefully through the selected activities. The study finally outlined some measures needed to overcome the problem identified on the student and recommended some important measures in training visually impaired persons to be able to move.
An Application of Kho-Kho Optimization Algorithm to Estimation Parameter of Permanent Magnet Synchronous Machine
Authors: Srivast Abhishek
Published: May 2023

Permanent magnet synchronous motors (PMSM) are among the popular motors used in industrial applications. Designing an appropriate control scheme to obtain the desired output for these motors depends on the motor parameters. In this aspect, this paper presents the application of a well-known meta-heuristics optimization scheme, i.e, Kho-Kho optimization (KKO) to estimate the parameters of PMSM. KKO introduced in [1] is a population-based meta-heuristic optimization scheme that replicated the chasing strategy of a defending team in a Kho-Kho game. To show the supremacy of the KKO scheme in determining the unknown parameters of the PMSM, a PMSM with known coefficients is considered and the parameter of the model is estimated using KKO.
On Ramanujan's Continued Fractions of Order Twenty-four
Authors: Rajkhowa Shraddha , Saikia Nipen
Published: May 2023

Two continued fractions U(q) and V(q) of order twenty-four are obtained from a general continued fraction identity of Ramanujan. Some theta-function and modular identities for U(q) and V(q) are established to prove general theorems for the explicit evaluations of U(±q) and V(±q). From the theta-function identities of U(q) and V(q), three colour partition identities are derived as application to partition theory of integer. Further, 2-, 4- and 8-dissection formulas are established for the continued fractions U*(q):=q-5/2 U(q) and V*(q)=q-1/2V(q), and their reciprocals.
2020 Mathematical Subject Classification: 33B70; 11F27; 11A55; 11P84.
SHRSE:Multimodal Short Video Hashtag Recommendation based on Sentiment Enhancement
Authors: Gupta Anish , Blake Romy , Riley Camden , Kapoor Priya
Published: May 2023

With the advent of social media platforms the trend of uploading text, pictures, and videos to express personal feelings has resulted in an explosion in the number of short videos on the internet. However, the accumulation of these short videos has resulted in a serious information overload problem, making it challenging for users to find their desired content. Hashtags are an effective solution to alleviate this problem, but users often do not have the habit of adding appropriate hashtags to their tweets. Hence, recommending suitable hashtags has become an important research area in recent years. The multimodality of short videos makes the hashtag recommendation process more challenging than text or image-only recommendation. In this paper, we explore the use of image, audio, and text modalities to achieve a more comprehensive understanding of short videos and design corresponding solutions to improve the accuracy of hashtag recommendation. We provide a comprehensive review of recent research on short video hashtag recommendation and identify the challenges and opportunities for future research.
Evaluation of global climate models for the simulation of precipitation and maximum and minimum temperatures at coarser and finer resolutions based on temporal and spatial assessment metrics in mainland of China
Authors: Lei Yawen , Peng Peiyi , Jiang Wencui
Published: May 2023

Many studies have evaluated the performance of multiple global climate models (GCMs) from a temporal or spatial perspective at finer resolution, but no study has evaluated the performance of individual GCMs at different resolutions and before and after bias correction from both temporal and spatial perspectives. The goal of this study is to evaluate the performance of 21 Coupled Model Inter-comparison Project 6 (CMIP6) GCMs at the raw (coarser) and downscaled (finer) resolutions and after bias correction in relation to their skills in the simulation of daily precipitation and maximum and minimum temperatures over China for the period 1961–2014 using state-of-the-art temporal and spatial metrics, Kolmogorov–Smirnov statistic and SPAtial EFficiency. The results indicated some differences in the ranks of GCMs between temporal and spatial metrics at different resolutions. The overall ranking shows that the simulations at the raw resolution of GCMs are more similar to the observations than the simulations after inverse distance weighted interpolation in SPAtial EFficiency. Three variables from bias-corrected GCMs ranked from 1 to 21 show similar good performance in spatial patterns but the poorest trend in empirical Cumulative Distribution Functions (ECDFs) except daily precipitation.
Arquivo, memória, obra poética: um mapa para redescobrir a cidade e seu poeta
Authors: Evelise Moraes Ribas  , Taiza Mara Rauen Moraes
Published: May 2023

O presente artigo alinha reflexões sobre as múltiplas significações do arquivo pessoal do poeta Marcos Konder Reis (MKR) que subsidiam a pesquisa de dissertação Poesia e cidade: uma cartografia das memórias de Marcos Konder Reis, vinculada à linha de pesquisa Memória e Linguagens do Programa de Pós-Graduação em Patrimônio Cultural e Sociedade da Universidade da Região de Joinville (PPGPCS/ Univille) e ao Grupo de Estudos Imbricamentos de Linguagens. A pesquisa teve por foco a investigação da relação entre a poética de MKR e a cidade de Itajaí da década de 1930 – narrada em seus poemas e marcadas em suas memórias –, por fonte o arquivo pessoal do poeta e por percurso de pesquisa o processo cartográfico. Para pensar sobre a trajetória dos arquivos públicos ou particulares no Brasil e sua importância para os pesquisadores, tivemos como referência Bacellar (2008). Os arquivos pessoais de artistas, suas características e importância para a compreensão do processo criativo e a formação de memórias coletivas são objetos de estudos de Severino (2021), estudos estes que sustentaram as reflexões críticas. Para compreender o funcionamento do Centro de Documentação e Memória Histórica de Itajaí como repositório de arquivos pessoais, os registros de Estork (2000) foram fundamentais. Os conceitos de pesquisa cartográfica, mapas, rizoma e rede foram ancorados nas discussões propostas por Costa (2014), Deleuze (2011) e Santaella (2008). Os poemas analisados na pesquisa de mestrado e citados neste trabalho têm curadoria publicada por Radünz e Floriano (2008).
Tratamento de dentes traumatizados com rizogênese incompleta – apicificação
Authors: Melissa Andréia MARCHESAN  , Edson ALFREDO  , Alexandre Rossi SUFREDINI  , Felipe Barros MATOSO  , Luis Pascoal VANSAN  , Manoel D. SOUSA NETO
Published: May 2023

Introdução e objetivo: Buscou-se apresentar dois casos clínicos dedentes traumatizados cujos ápices se apresentavam radiograficamenteabertos e cujos elementos dentais estavam sem fratura. Relato de caso:Nesses casos, a instrumentação deve ser realizada com leve pressãodo instrumento contra as paredes, em virtude da pequena espessuradelas. Sendo assim, a escolha da solução irrigante torna-sefundamental, uma vez que suas propriedades químicas específicassuprirão a deficiência do preparo mecânico. Curativos à base dehidróxido de cálcio e propilenoglicol foram feitos e trocados em períodosde 7 dias, 15 dias, 3 trocas a cada 30 dias e uma troca após 3 meses,até a formação de barreira apical calcificada, período no qual se obturouo canal com a técnica de cone único e cimento Grossman. Conclusão:A conduta clínica utilizada proporcionou a formação de barreira apicalcalcificada, restituindo o equilíbrio biológico e funcional da estruturadental e garantindo o sucesso do tratamento.
Clorexidina na terapia endodôntica
Authors: André Luiz da Costa MICHELOTTO  , Bruna Martins de ANDRADE  , Joel Alves da SILVA JÚNIOR  , Gilson Blitzkow SYDNEY
Published: May 2023

Introdução e objetivo: Este trabalho buscou realizar uma revisão deliteratura sobre o emprego da clorexidina no tratamento endodôntico.Revisão da literatura e conclusão: Foram estudadas as propriedadesantimicrobianas, de substantividade, biocompatibilidade, capacidadede limpeza e de dissolução tecidual da clorexidina. Em virtude de suaeficácia antimicrobiana, essa droga pode ser empregada comosubstância irrigadora durante o preparo químico-mecânico, assim comona fase medicamentosa, em casos de polpa morta. Por não possuircapacidade de dissolução tecidual, sua indicação torna-se limitada.Quando comparada às demais concentrações, a clorexidina naconcentração de 2% tem apresentado maior efetividade bactericida,com baixa toxicidade. Parece-nos claro que sua efetividade é muitomaior como irrigante do que como substância auxiliar na forma de gel.Entretanto recentes estudos sobre a sua genotoxicidade conduzem aum alerta sobre sua indicação segura na terapia endodôntica.
Cirurgia paraendodôntica: relato de caso clínico
Authors: Letícia Marchetti LODI  , Sheila POLETO  , Renata Grazziotin SOARES  , Luis Eduardo Duarte IRALA  , Alexandre Azevedo SALLES  , Orlando LIMONGI
Published: May 2023

Introdução: A cirurgia paraendodôntica é um procedimento que tem comofinalidade resolver problemas que não puderam ser solucionados pelotratamento endodôntico convencional, ou quando este não é possível.Relato do caso e conclusão: Neste trabalho há o relato de um caso clínicode dentes portadores de coroas protéticas com pinos intra-radiculares,em que se optou pela realização do procedimento cirúrgico. Foramefetuadas apicectomia e retroobturação com MTA no dente 11, apicectomiano dente 21 e apicectomia, retroinstrumentação e retrobturação com MTAno dente 22.
Tratamento da periimplantite: revisão da literatura
Authors: Leonardo FRANCIO  , Andrea Maria de SOUSA  , Carmen Lucia Mueller STORRER  , Tatiana Miranda DELIBERADOR  , Eduardo PIZZATTO  , Tertuliano Ricardo LOPES
Published: May 2023

Introdução e objetivo: Este estudo teve como objetivo revisar naliteratura as principais modalidades de tratamento de periimplantite.Foi relatado o uso de antissépticos bucais, antibioticoterapia, raspagemcirúrgica, raspagem não-cirúrgica, enxerto ósseo, uso de membranas,tratamento combinado com uso de enxertos ósseos e membranas elaserterapia. Revisão de literatura: A maioria dos estudos mostrou casossobre os tipos de tratamento, porém apenas um protocolo específico dadoença foi relatado. Todos os outros demonstraram associações detratamentos com sucesso na maioria absoluta dos casos,independentemente do tratamento realizado. Conclusão: A associação de técnicas de tratamento é válida e, muitas vezes, necessária. Contudo,para chegarmos a uma conclusão mais específica, devem ser feitosmais estudos em humanos a respeito de cada tipo de tratamento.
A Review on the Efficacy and Safety of Intrathecal Administration of
Novel Medications for Leptomeningeal Metastases in Solid Cancers
Authors: Jafari Fatemeh , Nodeh Mohammad Moeini , Hosseinjani Hesamoddin , Baharara Hamed , Azad Sajad , Arasteh Omid , Johnston Thomas P. , Sahebkar Amirhossein
Published: May 2023

Leptomeningeal disease (LMD) is a rare and lethal manifestation that may occur
in the advanced stages of solid tumors and hematological malignancies. With advances
in diagnostic techniques, the detection and confirmation of the presence of LMD
have increased. Although its optimal treatment remains a challenge, the use of the intrathecal
route for the delivery of novel therapeutics is now considered a promising drug
delivery strategy to complement radiation and systemic-based therapies. Although
methotrexate, cytarabine, and thiotepa have a long history in the treatment of LMD, other
medications have also been shown to be beneficial. In this article, we have reviewed the
effects of novel medications administered via the intrathecal route for the treatment of
solid tumors. We have searched PubMed, Scopus, and Google Scholar databases till the
end of September 2021 using the following keywords: “leptomeningeal disease”, “leptomeningeal
carcinomatosis”, “leptomeningeal metastases”, “solid tumors”, “solid cancers”,
and “intrathecal”. Our literature findings have uncovered that most studies on
LMD, which occurs secondary to solid cancers, are available as ‘case reports’, and few
clinical trials have been conducted to date. Single-drug (monotherapy) or combination
drug therapy, administered via the intrathecal route, especially in metastatic breast and
lung cancer, has been shown to improve patients' symptoms and overall lifespan, while
exhibiting a low and acceptable prevalence of side effects. However, judgments/conclusions
about the effectiveness and safety of these drugs still require further clinical evaluation.
Polyvinyl Alcohol Nanofibers Blends as Drug Delivery System in Tissue
Regeneration
Authors: Barros Araújo Camila Beatriz , da Silva Soares Ingrid Larissa , da Silva Lima Diego Paulo , Barros Rafaella Moreno , de Lima Damasceno Bolívar Ponciano Goulart , Oshiro-Junior João Augusto
Published: May 2023

Nanofibers have shown promising clinical results in the process of tissue regeneration since they provide
a similar structure to the extracellular matrix of different tissues, high surface-to-volume ratio and porosity,
flexibility, and gas permeation, offering topographical features that stimulate cell adhesion and proliferation.
Electrospinning is one of the most used techniques for manufacturing nanomaterials due to its simplicity and
low cost. In this review, we highlight the use of nanofibers produced with polyvinyl alcohol and polymeric associations
(PVA/blends) as a matrix for release capable of modifying the pharmacokinetic profile of different active
ingredients in the regeneration of connective, epithelial, muscular, and nervous tissues. Articles were selected
by three independent reviewers by analyzing the databases, such as Web of Science, PubMed, Science Direct,
and Google Scholar (last 10 years). Descriptors used were “nanofibers”, “poly (vinyl alcohol)”, “muscle
tissue”, “connective tissue”, “epithelial tissue”, and “neural tissue engineering”. The guiding question was:
How do different compositions of polyvinyl alcohol polymeric nanofibers modify the pharmacokinetics of active
ingredients in different tissue regeneration processes? The results demonstrated the versatility of the production
of PVA nanofibers by solution blow technique with different actives (lipo/hydrophilic) and with pore
sizes varying between 60 and 450 nm depending on the polymers used in the mixture, which influences the
drug release that can be controlled for hours or days. The tissue regeneration showed better cellular organization
and greater cell proliferation compared to the treatment with the control group, regardless of the tissue analyzed.
We highlight that, among all blends, the combinations PVA/PCL and PVA/CS showed good compatibility
and slow degradation, indicating their use in prolonged times of biodegradation, thus benefiting tissue regeneration
in bone and cartilage connective tissues, acting as a physical barrier that results in guided regeneration,
and preventing the invasion of cells from other tissues with increased proliferation rate.
Searching for Essential Genes and Targeted Drugs Common to Breast
Cancer and Osteoarthritis
Authors: Guo Liantao , Kong Deguang , Liu Jianhua , Luo Lan , Zheng Weijie , Chen Chuang , Sun Shengrong
Published: May 2023

Background:

It is documented that osteoarthritis can promote the progression of breast
cancer (BC).

Objective:

This study aims to search for the essential genes associated with breast cancer (BC) and
osteoarthritis (OA), explore the relationship between epithelial-mesenchymal transition (EMT)-
related genes and the two diseases, and identify the candidate drugs.

Methods:

The genes related to both BC and OA were determined by text mining. Protein-protein
Interaction (PPI) analysis was carried out, and as a result, the exported genes were found to be related
to EMT. PPI and the correlation of mRNA of these genes were also analyzed. Different kinds
of enrichment analyses were performed on these genes. A prognostic analysis was performed on
these genes for examining their expression levels at different pathological stages, in different tissues,
and in different immune cells. Drug–gene interaction database was employed for potential
drug discovery.

Results:

A total number of 1422 genes were identified as common to BC and OA and 58 genes
were found to be related to EMT. We found that HDAC2 and TGFBR1 were significantly poor in
overall survival. High expression of HDAC2 plays a vital role in the increase of pathological stages.
Four immune cells might play a role in this process. Fifty-seven drugs were identified that
could potentially have therapeutic effects.

Conclusion:

EMT may be one of the mechanisms by which OA affects BC. Using the drugs can
have potential therapeutic effects, which may benefit patients with both diseases and broaden the
indications for drug use.
Structural Insights into N-heterocyclic Moieties as an Anticancer Agent
against Hepatocellular Carcinoma: An Exhaustive Perspective
Authors: Chourasiya Nikhil Kumar , Fatima Firdous , Mishra Mitali , Kori Shivam , Das Ratnesh , Kashaw Varsha , Iyer Arun K. , Kashaw Sushil Kumar
Published: May 2023

Hepatocellular carcinoma (HCC) is rapidly spreading around the world with a high mortality
rate. In the low- and middle-income nations most impacted by HCV and HBV infections, HCC
places a significant strain on the healthcare system and leaches productive capability. An extensive
study on HCC to create novel therapeutic approaches was motivated by the lack of adequate preventive
or curative therapy methods. Several medications have been put forward and some drug molecules
are under investigation by the Food and Drug Administration (FDA) for the treatment of HCC.
However, these therapeutic choices fall short of the ideal due to toxicity and the rapid rise in drug
resistance which decreases the efficacy of these therapeutics and leads to the severity of hepatocellular
carcinoma. Therefore, concerning these problems, there is a critical need for novel systemic combination
therapies as well as novel molecular entities that target various signalling pathways, reducing
the likelihood that cancer cells may develop treatment resistance. In this review, we discuss the
conclusions of several studies suggesting that the N-heterocyclic ring system is a key structural component
of many synthetic drugs with a diverse range of biological activities. Following nuclei, such
as pyridazine, pyridine, and pyrimidines, along with benzimidazole, indole, acridine, oxadiazole,
imidazole, isoxazole, pyrazole, quinolines, and quinazolines, have been included to provide a general
overview of the link between structure and activity between heterocyclics and their derivatives
against hepatocellular carcinoma. A comprehensive investigation of the structure-activity relationship
between the series may be done by the direct comparison of anticancer activities with the reference.
Local Multiple-site Injections of a Plasmid Encoding Human MnSOD Mitigate
Radiation-induced Skin Injury by Inhibiting Ferroptosis
Authors: Wang Xiaoying , Lu Yuxin , Cheng Xiaochen , Zhu Xuefeng , Li Dujuan , Duan Haiying , Hu Shenhui , Xiao Fengjun , Du Li , Zhang Qinglin
Published: May 2023

Background:

Most patients who undergo radiotherapy develop radiation skin injury, for
which effective treatment is urgently needed. MnSOD defends against reactive oxygen species (ROS)
damage and may be valuable for treating radiation-induced injury. Here, we (i) investigated the therapeutic
and preventive effects of local multiple-site injections of a plasmid, encoding human MnSOD, on
radiation-induced skin injury in rats and (ii) explored the mechanism underlying the protective effects of
pMnSOD.

Methods:

The recombinant plasmid (pMnSOD) was constructed with human cytomegalovirus (CMV)
promoter and pUC-ori. The protective effects of pMnSOD against 20-Gy X-ray irradiation were evaluated
in human keratinocytes (HaCaT cells) by determining cell viability, ROS levels, and ferroptosisrelated
gene expression. In therapeutic treatment, rats received local multiple-site injections of pMnSOD
on days 12, 19, and 21 after 40-Gy γ-ray irradiation. In preventive treatment, rats received pMnSOD
injections on day -3 pre-irradiation and on day 4 post-irradiation. The skin injuries were evaluated based
on the injury score and pathological examination, and ferroptosis-related gene expression was determined.

Results:

In irradiated HaCaT cells, pMnSOD transfection resulted in an increased SOD2 expression,
reduced intracellular ROS levels, and increased cell viability. Moreover, GPX4 and SLC7A11 expression
was significantly upregulated, and erastin-induced ferroptosis was inhibited in HaCaT cells. In the
therapeutic and prevention treatment experiments, pMnSOD administration produced local SOD protein
expression and evidently promoted the healing of radiation-induced skin injury. In the therapeutic
treatment experiments, the injury score in the high-dose pMnSOD group was significantly lower than in
the PBS group on day 33 post-irradiation (1.50 vs. 2.80, P < 0.05). In the prevention treatment experiments,
the skin injury scores were much lower in the pMnSOD administration groups than in the PBS
group from day 21 to day 34. GPX4, SLC7A11, and Bcl-2 were upregulated in irradiated skin tissues
after pMnSOD treatment, while ACSL4 was downregulated.

Conclusion:

The present study provides evidence that the protective effects of MnSOD in irradiated
HaCaT cells may be related to the inhibition of ferroptosis. The multi-site injections of pMnSOD had
clear therapeutic and preventive effects on radiation-induced skin injury in rats. pMnSOD may have
therapeutic value for the treatment of radiation-induced skin injury.
Insight into the Basic Mechanisms and Various Modulation Strategies
Involved in Cancer Drug Resistance
Authors: Yadav Devdhar , Rao Gudhanti Siva Naga Koteswara , Paliwal Deepika , Singh Amit , Shadab Sumbul
Published: May 2023

It is possible for tumors to develop resistance to currently used drugs. However, its increasing
incidence necessitates further study and the development of novel therapies This review explores
our current understanding of the factors that enable drug resistance, which include, inactivation of the
drug, reduced drug uptake, increased drug efflux, metabolic effect, inhibition of apoptosis, epithelialmesenchymal
transition, modified membrane transport, and heterogeneity of inherent tumor cell. This
manuscript will also explore some genetic and epigenetic alterations that may encourage drug resistance
and fundamental mechanisms of the reluctance of drugs in leukemia, ovarian and breast cancer
and it concludes with a few solutions for managing drug resistance.
A Bird's Eye Review of Recent Reports on 1,3,4-oxadiazoles' Anti-inflammatory Insights Perspectives
Authors: Chaudhary Tarun , Upadhyay Prabhat Kumar
Published: May 2023

Anti-inflammatory agents suppress inflammatory mediators such as prostaglandins, prostacyclins,
cytokines, thromboxane, histamine, bradykinins, COX-I and COX-II, 5-LOX, and other substances.
These inflammatory chemicals create inflammatory responses when tissue is injured by trauma,
bacteria, heat, toxins, or other factors. These inflammatory reactions may result in fluid flow from
the blood vessels into the tissues, resulting in swelling. When the therapeutic importance of these clinically
beneficial medications in treating inflammation was recognized, it spurred the invention of even
more powerful and important molecules. Oxadiazole derivatives are exceptionally potent NSAIDs, and
they are widely used. Comprehensive biochemical, structure-activity-relationship and pharmacological
investigations have demonstrated that these 1,3,4-oxadiazole compounds exhibit anti-inflammatory
properties. This review article outlines the synthesis scheme for 1,3,4-oxadiazole used in treating inflammation.
Distinctive Clinico-electrographic and Radiological Profile of Childhood and Adolescent Seizures
Authors: Prabha Rashmie , Bhakat Rahul , Mohan Kriti , Rajvanshi Nikhil , Chacham Swathi , Mohan Latika
Published: May 2023

Aim:

Electroencephalogram (EEG) is specific, but not sensitive, for the diagnosis of epi- lepsy. This study aimed to correlate the clinico-electrographic and radiological features of seizure disorders in children attending a tertiary care centre in northern India.

Methods:

Children aged between one to 18 years with seizure episodes were included. Clinical de- tails, including historical as well as physical findings, were evaluated along with EEG and neuroim- aging (Magnetic resonance imaging). Details were noted on pre-designed proforma. Variables were analysed by using appropriate statistical methods.

Results:

A total of 110 children with seizures were enrolled in the study. Male to female ratio was 1.6: 1, and the mean age of the study children was 8 years. The majority of the children were symp- tomatic for more than one year. The most common seizure type was Generalised Tonic Clonic Sei- zure (GTCS), and Hypoxic-ischemic Encephalopathy (HIE) sequelae was the most commonly at- tributed etiology, followed by neurocysticercosis. EEG and neuroimaging findings were found to correlate well with seizure semiology from history. The incidence of febrile seizures was 10% in this study, with nearly three-fourths of them being simple febrile seizures.

Conclusion:

Microcephaly and developmental delay were the most distinctive clinical correlates in children with seizures. There was a fair agreement between the types of seizures described in histo- ry and depicted on EEG with Cohen’s kappa of 0.4. Also, there was a significant association be- tween the type of seizures on EEG and the duration of symptoms.
An Efficient Ensemble-based Machine Learning approach for Predicting
Chronic Kidney Disease
Authors: Chhabra Divyanshi , Juneja Mamta , Chutani Gautam
Published: May 2023

Background:

Chronic kidney disease (CKD) is a long-term risk to one’s health that can result in kidney failure. CKD is one of today's most serious diseases, and early detection can aid in proper treatment. Machine learning techniques have proven to be reliable in the early medical diagnosis.

Objective:

The paper aims to perform CKD prediction using machine learning classification approaches. The dataset used for the present study for detecting CKD was obtained from the machine learning repository at the University of California, Irvine (UCI).

Methods:

In this study, twelve machine learning-based classification algorithms with full features were used. Since the CKD dataset had a class imbalance issue, the Synthetic Minority Over-Sampling technique (SMOTE) was used to alleviate the problem of class imbalance and review the performance based on machine learning classification models using the K fold cross-validation technique. The proposed work compares the results of twelve classifiers with and without the SMOTE technique, and then the top three classifiers with the highest accuracy, Support Vector Machine, Random Forest, and Adaptive Boosting classification algorithms were selected to use the ensemble technique to improve performance.

Results:

The accuracy achieved using a stacking classifier as an ensemble technique with cross-validation is 99.5%.

Conclusion:

The study provides an ensemble learning approach in which the top three best-performing classifiers in terms of cross-validation results are stacked in an ensemble model after balancing the dataset using SMOTE. This proposed technique could be applied to other diseases in the future, making disease detection less intrusive and cost-effective.
Determination Of Aflatoxin M1 In Raw Cow's Milk Using Hplc- Fld, In Injibara Town, Awi Zone, Amhara, Ethiopia
Authors: Talema Alemu , Kassa Adisie
Published: May 2023

Background:

Consumption of contaminated milk is a major health problem for consumers, and aflatoxins are potent liver carcinogens, mutagens, and immunosuppressive compounds. Therefore, raw cow milk must be constantly monitored for the presence of AFM1 contamination. It is extremely important to keep AFM1 levels low in raw cow’s milk. The level of AFM1 in milk varies depending on the level of AFB1 ingested by dairy cattle through the feed.

Objective:

This investigation is mainly focused on the detection of levels of AFM1 in raw cow’s milk. There is little information on the level and distribution of aflatoxin in raw milk samples from cows in the vicinity of Injibara Town. Therefore, it is important to analyze the level and distribution of aflatoxin in raw milk samples from cows in Injibara Town.

Methods:

This study is mainly a quantitative investigation of the amount of AFM1 in raw cow’s milk using the HPLC-FLD spectrometry methods. All the milk samples were collected using a random sampling technique method from different areas during the night and morning a day and the collected raw cow’s milk samples were stored in a clean polyethylene bag.

Results:

In the present study, a total of 324 raw cow’s milk samples were collected from farmers in Injibara town, and samples were analyzed in triplicate for AFM1 determination by HPLC-FLD. Aflatoxin M1 was detected in 3 (0.92 percent of whole samples) out of 324 samples with quantities ranging from 0.046 to 0.22 µg/L and a mean value of 0.121 µg/L. From 324 raw cow’s milk samples, two (0.62 %) were seen over and one sample (0.31 %) was below the permissible limits of EU and ES (0.05 µg/L. The most number of samples were not detected in AFM1 analysis.

Conclusions:

From this result conclude that two samples (0.096 and 0.22 μg/L) were over the EU (0.05μg/L) and ES (0.05μg/L) permitted levels and under analysis, one sample (0.046 μg/L) was below the standard limit in the USA (0.5 μg/L). The average contamination was 0.121µg/L and this data revealed that the raw cow’s milk is to a small extent contaminated with aflatoxins.
Advancements in Yoga Pose Estimation Using Artificial Intelligence: A
Survey
Authors: Chamola Vinay , Gummana Egna Praneeth , Madan Akshay , Rout Bijay Kumar , Coelho Rodrigues Joel José Puga
Published: May 2023

Human pose estimation has been a prevalent field of computer vision and sensing study. In
recent years, it has made many advances that have helped humanity in the fields of sports, surveillance,
healthcare, etc. Yoga is an ancient science intended to improve physical, mental and spiritual wellbeing.
It involves many kinds of asanas or postures that a practitioner can perform. Thus, the benefits
of pose estimation can also be used for Yoga to help users assume Yoga postures with better accuracy.
The Yoga practitioner can detect their own current posture in real-time, and the pose estimation method
can provide them with corrective feedback if they commit mistakes. Yoga pose estimation can also help
with remote Yoga instruction by the expert teacher, which can be a boon during a pandemic. This paper
reviews various Machine Learning, Artificial Intelligence-enabled techniques available for real-time
pose estimation and research pursued recently. We classify them based on the input they use for estimating
the individual's pose. We also discuss multiple Yoga posture estimation systems in detail. We
discuss the most commonly used keypoint estimation techniques in the existing literature. In addition to
this, we discuss the real-time performance of the presented works. The paper further discusses the datasets
and evaluation metrics available for pose estimation.
Bromoaldehyde as a Useful Starting Materials for the Synthesis of Various
Hetero Cyclic and Carbocylic Molecules by Pd-catalyzed Reaction
Authors: Dewan Mitali , Kundu Debasish , Jana Rathin
Published: May 2023

This short review presents an overview of the effectiveness of β-bromoaldehyde as synthetic
tool in organic chemistry. Few groups have reported significant contributions on β-bromoaldehyde. The
aim of our short review was to give an overview of the latest advances in the chemistry of βbromoaldehyde from their preparation to their transformations and applications in organic synthesis of
some heterocyclic and carbocyclic molecules by using palladium-catalyzed reaction.
Role of Bioactive Compounds in the Regulation of Hemostasis: Lessons
from Nature
Authors: Affrald R. Jino
Published: May 2023

The maintenance of hemostasis is a crucial component of the healing process for
wounds. Hemostasis may be disrupted when there is a genetic abnormality in the process of platelet
production or blood coagulation. The use of herbal remedies derived from plants native to India
that exhibit a broad range of physicochemical qualities is becoming more common. This study uses
an electronic database to investigate the hemostatic action of commonly accessible medicinal
herbs, as well as the bioactive components and potential mechanisms behind this activity. It is possible
that the transformation of traditional medicine into pharmaceuticals might be facilitated by
taking into account the therapeutic characteristics of spices, garden plants, and wild plants. This
review discusses a variety of topics related to plants, including their bioactivities, clinical uses, Indian
traditional medicinal approaches, and modern developments. It includes several herbs and
spices that have therapeutic and hemostatic properties. Extensive study is required prior to the use
of herbal treatments within the context of the present healthcare system. This study deals with
making a strategy to discover new medical plant-based therapeutic compounds and keeping track
of the ones you already have.
Saudi Arabia's Efforts to Maintain Global Oil Supply in the Persian Gulf
Authors:   University of Muhammadiyah Malang, Nur Rizky Muhammad , Prasodjo Haryo ,   University of Muhammadiyah Malang
Published: May 2023

The purpose of this study is to describe Saudi Arabia's efforts to maintain global oil supplies in the Persian Gulf. The research method used is descriptive qualitative using library research as a data collection technique. The results obtained from this study are that the efforts made by Saudi Arabia in maintaining global oil supplies in the Persian Gulf consist of two efforts, namely military and non-military efforts. Saudi Arabia's military efforts are joining the United States maritime coalition to carry out sentinel operations and conducting Sentinel Coalition Task Force (CTF) exercises as an increase in security cooperation between Saudi Arabia and the United States to protect oil shipments in the Persian Gulf. As for the non-military efforts made by Saudi Arabia, namely by holding an emergency meeting with the Gulf countries to inform them that a serious effort or effort is needed to protect the security of shipping in the Persian Gulf because of attacks that have occurred before, namely on two Saudi Arabian tankers which were sabotaged and released. the coast of Fujairah and drone attacks on oil fields or oil processing facilities in the Saudi cities of Khurais and Abqaiq.
Comparison of Methanolic Extract of Piper Betle to Amikacin against the Growth of Pseudomonas aeruginosa
Authors: Rysaputri Azalia Ayu , Susilo Hery , Hidayati Dwi Yuni Nur , Ratridewi Irene
Published: May 2023

Pseudomonas aeruginosa is one of the most common pathogens that cause Healthcare-Associated Infections (HAIs). A previous study stated that Piper betle L. extract has antibacterial activity against certain bacteria, including Pseudomonas aeruginosa. This study has the objective of comparing antibacterial activity of the methanolic extract of Piper betle L. and amikacin on the growth of Pseudomonas aeruginosa. This study used the tube dilution method with a sample of Pseudomonas aeruginosa from Microbiology Laboratory Dr. Saiful Anwar General Hospital, Malang. The results of this study showed that the value of MIC and MBC from the methanolic extract of the Piper betle L. treatment was 4800μg/mL. Meanwhile, the amikacin treatment resulted in 0.4μg/mL for MIC and 0.45μg/mL for MBC. From linear regression, it was found that the methanolic extract of Piper betle L. had a β-coefficient value closer to -1 compared to amikacin. Therefore, it can be concluded that the methanolic extract of Piper betle L. has a greater inhibiting effect on the growth of Pseudomonas aeruginosa.
Qual o papel do diretor na autonomia e flexibilidade curricular? A perceção dos docentes
Authors: Simões Cristina , Sousa João
Published: May 2023

Seria incongruente se a escola não acompanhasse o ritmo de mudança da sociedade, constituindo a Autonomia e Flexibilidade Curricular (AFC) uma janela de oportunidades para a sua inovação. Tendo em conta a perceção dos professores, a presente investigação tem como objetivo conhecer o papel do diretor na implementação da AFC, refletindo-se sobre o impacto da liderança transformacional na gestão das matrizes curriculares-base. A amostra foi constituída por 172 docentes, que preencheram um questionário composto por três partes, que incluía a versão portuguesa do Questionário de Liderança Transformacional (QLT). Os dados foram analisados com recursos ao Statistical Package for the Social Sciences (SPSS). Os resultados enfatizam o envolvimento dos diretores na implementação da AFC, dando especial relevo à promoção da educação inclusiva e à gestão da gramática escolar facilitadora do processo. Não obstante, estas lideranças de topo deixam para segundo plano o envolvimento dos docentes, dos alunos e das famílias, a constituição de equipas educativas e a implementação do trabalho colaborativo. Marcadamente caracterizados por comportamentos transformacionais e transacionais, foi possível concluir que quanto mais os diretores desempenham uma liderança transformacional, maior é a gestão das matrizes curriculares-base.
Klimaatfictie tussen hoop en vrees
Authors: Craps Stef
Published: May 2023

De vroege eenentwintigste eeuw zag een golf van literaire teksten waarin de klimaatverandering centraal staat. Dit artikel bespreekt wat tegenwoordig klimaatfictie of “clifi” wordt genoemd als een alternatieve vorm van klimaatcommunicatie, omarmd niet alleen door literatuurliefhebbers maar ook door wetenschappers en activisten die tegen de grenzen van het informatietekort-model aanlopen in hun pogingen om bewustwording en gedragsverandering te bewerkstelligen. Bijzondere aandacht wordt besteed aan de opkomende trend van hoopvolle, utopische klimaatverhalen als tegenwicht voor de dominantie van het post-apocalyptische genre, waarvan de effectiviteit steeds meer ter discussie staat.
De heerlijke rekening als historische bron: een stand van het onderzoek betreffende het graafschap Vlaanderen (ca. 1450 – ca. 1795)
Authors: De Waele Tom
Published: May 2023

This article provides an overview of the historiography on seigneurial accounts in Flanders from circa 1450 until the end of the Old Regime. The main objective is hereby to explore the main characteristics of this socioeconomic source material, and how it has been used in historical studies of premodern Flanders. Furthermore, the possibilities and methodologies for future research based on seigneurial financial administrative documents are covered as well. Such future research is needed in this field, which predominantly draws upon generalizations from isolated case studies, rather than structural comparative analysis.
Meertaligheid als strategie voor zelfontplooiing in de briefwisselingen van Marie-Jeanne Riccoboni en Isabelle de Charrière
Authors: Jacques Amélie
Published: May 2023

In Enlightenment Europe multilingualism was an omnipresent fact. Even the correspondences of eighteenth-century writers gave clear evidence of – often strategically chosen – forms of multilingualism. Up until today, the question arises as to why early modern writers used (various forms of) multilingualism in their letters. This paper investigates, for the first time, the hypothesis that early modern writers used multilingualism in their letter writing as a strategy for intellectual and authorial self-fashioning. To that end, it explores the multilingual dimensions of two women writers’ correspondences. Studying the way in which Marie-Jeanne Riccoboni (1713-1792) and Isabelle de Charrière (1740- 1805) actively (re)shaped their intellectual authority and authorial identity by means of multilingualism will prove to provide an excellent stepping stone towards more (comparative) research on the forms and functions of multilingualism in the (life) writing of eighteenth-century male and female writers.
De multimodale uitdrukking van motion events in het Frans en het Nederlands als T1 en T2: Pilootstudie
Authors: Piot Christina
Published: May 2023

Verschillende studies hebben gesuggereerd dat de typologische verschillen tussen verbframed en satellite-framed talen in co-verbale gebaren worden weerspiegeld. Tegen deze achtergrond heeft de huidige pilootstudie als doeleinden (1) te beschrijven hoe specifieke motion events uitgedrukt worden door Franstalige moedertaalsprekers, Nederlandstalige moedertaalsprekers en Franstalige leerders van het Nederlands om hypotheses te formuleren voor verder onderzoek en (2) een methode te testen. Er werd een experiment uitgevoerd waarin er aan de deelnemers werd gevraagd scènes uit een aflevering van de animatieserie Tweety & Sylvester te beschrijven. Hun talige producties en hun gebaren werden dan geanalyseerd. Deze preliminaire resultaten geven een overzicht van de manier waarop de FR1-, NL1- en NL2-sprekers de aspecten manier en pad coderen en combineren in hun spraak en gebaren. Ze leiden tot vijf hypotheses die binnenkort in een vervolgonderzoek zullen worden getest.
De Spaanse inchoatiefconstructie in beeld. Clusteranalyse als antwoord op het quasi-synonymie vraagstuk
Authors: Van Hulle Sven , Enghels Renata
Published: May 2023

This study about the productivity and the near-synonymy of the inchoative construction in Peninsular Spanish reveals that at least 25 verbs can enter the auxiliary slot. These auxiliaries are recruited from six semantic domains: (1) superlexical inherent inchoative verbs, (2) put verbs, (3) throw verbs, (4) movement verbs, (5) manual manipulation verbs and (6) verbs of destruction. This study confirms that a hierarchical cluster analysis is suited to investigate the near-synonymy of semantically related verbs as it unfolds interesting clusters for the inchoative auxiliaries. Concretely, the hierarchical cluster analysis divides the auxiliaries into three clusters. A first one with the superlexical auxiliaries (comenzar, empezar and iniciar), a second cluster with the put verbs (meter and poner) and a third cluster with the less grammaticalized and more lexicalized auxiliaries echarse and romper.
Laat of te Laat? Ouderdom in de laat Latijnse Elegieën van Maximianus (6e eeuw n.Chr.)
Authors: Van der Sype Nina
Published: May 2023

This article focuses on the poetry of Maximianus, a late Latin author whose work was published around the 6th century AD. His corpus is to be situated within the genre of the elegy; typically, these are written by a young and virile male poet, dedicated to the woman he loves and who dominates his life. However, the six elegies written by Maximianus (686 lines in total) are unique within the whole of Latin literature since they do not have love and youth as central subject. They explicitly put the motif of old age on the foreground. By combining a close reading with the methodological framework of “ageing studies”, this article proposes an analysis of some crucial passages taken from the opening poem of the corpus, in order to show how Maximianus interacts with the topic of old age within the boundaries of the elegy.
ESP students’ voice: Is Kahoot® helpful to learn English vocabulary during the pandemic?
Authors: Mandasari Yuyun Putri , Wulandari Eka
Published: May 2023

The use of technology is closely linked to the implementation of digital learning. As one of the profiles of the 21st century teachers, digital tools are notably prominent in helping ESP students improve their learning outcome, particularly during the Emergency Remote Learning (ERL) due to COVID-19.  Kahoot® as one of the technological advancements in the field of game-based learning was considered to be highly beneficial and helpful for ESP students to be more engaged and motivated in improving their English vocabulary through online means. This study presents ESP students’ perceptions of the use of Kahoot® in an internet-based instruction during the pandemic. Survey research was employed with 51 participating students of the Health Promotion Study Program at Poltekkes Kemenkes Malang. The questionnaire was distributed online with 21 survey items designed to accommodate the students’ points of view. The findings show that the students of the Health Promotion Department had a strong preference to the use of Kahoot® in improving their English vocabulary during the COVID-19 outbreak.