Assessment of the impact of an innovative nutraceutical on blood biomarkers: essential aminoacids, antioxidants, lipid profile and REDOX status
Authors: Orozco-Levi Mauricio , Pabón-Quezada Angie Rocío , Quintero-Lesmes Doris Cristina , Ramírez Vélez Andrés , Jaramillo López Juan Carlos , Serrano Norma C. , Castillo Victor R. , Serrano-García Angie Yarlady , Ramírez-Sarmiento Alba 
Published: January 2025

Purpose

Sedentary living and respiratory/cardiovascular diseases affect respiratory and peripheral muscles. Muscle training can prevent, improve and reverse these changes. Their research question suggests that precise nutraceutical administration can enhance antioxidant capacity and muscle function. This sudy aims to evaluate the impacto of an innovative nutraceutical on blood biomarkers such as essential aminoacids, antioxidants, lipid profile, and REDOX status in healthy individuals, stable Chronic Obstructive Pulmonary Disease (COPD) patients, and mechanically ventilated patients.

Design/methodology/approach

The authors designed a nutraceutical to assess its effects on serum amino acids, lipid profile, vitamins, minerals and reduction-oxidation function. Conducted at a high-complexity care hospital, a study with a non-equivalent group design compared pre- and post-treatment administration.

Findings

The 29 participants were categorized into healthy individuals (n = 10), chronic obstructive pulmonary disease (COPD) patients (n = 10) and COPD patients receiving mechanical ventilation in an intensive care unit (ICU, n = 9) due to exacerbation. Analyzing serum values of selected markers and components before and after nutraceutical intake revealed significant differences. Oxygen radical absorption capacity units significantly increased (p = 0.0051) in healthy individuals. Isoleucine, valine, phosphorus, magnesium and calcium levels significantly increased in the healthy group.

Research limitations/implications

The small sample size and short duration limit the generalizability of results. The non-equivalent group design and lack of randomization may introduce bias, affecting reliability. Future research should involve larger, randomized controlled trials to confirm HIC1® benefits. Additionally, exploring long-term effects and optimal dosing in various populations, including different COPD stages and other chronic conditions, will provide more comprehensive insights. Despite these limitations, the study suggests promising implications for enhancing muscle function and antioxidant capacity through precise nutraceutical administration.

Practical implications

The administration of HIC1® demonstrates potential for improving antioxidant capacity and muscle function, particularly in sedentary individuals and those with respiratory or cardiovascular diseases. This study’s findings suggest that even short-term use of HIC1® can lead to significant increases in serum amino acids and other vital nutrients. Health practitioners should consider incorporating nutraceuticals like HIC1® into treatment plans for COPD patients and those requiring mechanical ventilation. Future research and clinical practice should explore optimal dosing and long-term benefits, potentially improving patient outcomes in chronic disease management.

Social implications

The use of nutraceuticals like HIC1® could have a significant impact on public health, especially for vulnerable populations such as the elderly and those with chronic illnesses. Improving muscle function and antioxidant capacity can reduce dependence on intensive care, decrease the economic burden on healthcare systems and enhance patients’ quality of life. Additionally, access to effective nutraceutical treatments could democratize healthcare, providing an affordable complementary option for preventing and managing muscle and respiratory diseases, promoting healthy and active aging in society.

Originality/value

This study is pioneering in evaluating the effects of a specifically designed nutraceutical, HIC1®, on both healthy individuals and those with chronic respiratory conditions. By focusing on precise nutraceutical administration, it addresses the gap in research on non-pharmaceutical interventions for enhancing muscle function and antioxidant capacity. The findings provide valuable insights into the potential of HIC1® to improve clinical outcomes in COPD patients and those undergoing intensive care, offering a novel, natural and potentially cost-effective approach to complement traditional treatments and support overall health and well-being.