bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Brain Stimulation of the Anterior Limb of the Internal Capsule May Be Efficacious for Explosive Aggressive Behaviour
Authors: Giordano Flavio , Cavallo Michele , Spacca Barbara , Pallanti Stefano , Tomaiuolo Francesco , Pieraccini Fulvio , Fagiolini Andrea , Grandoni Manuela , Melani Federico , Zicca Anna , Sestini Stelvio , Genitori Lorenzo
Published: October 2016

Background: Intermittent explosive disease (IED) is a psychiatric disorder characterized by intermittent attacks of rage and violence frequently resistant to pharmacological therapy. Deep brain stimulation (DBS) of the posteromedial hypothalamus has been applied with fair results and clinical improvement with some surgical morbidity due to neurovegetative side effects. The anterior limb of the internal capsule/ventral capsule/ventral striatum (VC/VS) has never been used alone as a target for this disease. Objectives: The aim of this study is to evaluate the efficacy of bilateral DBS of the VC/VS for the treatment of IED. Methods: We performed bilateral DBS of the VC/VS in a 21-year-old patient with IED. This young man had a traumatic birth complicated by hypoxia, and he showed a mild mental impairment. Different pharmacological treatments were carried out with no results before DBS was proposed to the patient's relatives after multidisciplinary approval. Results: After 22 months of high-frequency monopolar bilateral DBS of the VC/VS, the patient showed a significant improvement. Postoperative 18F-FDG PET-CT studies ruled out a reduction of the hypermetabolic areas located in the limbic system previously detected in pre-operative investigations. Conclusions: Bilateral DBS of the VC/VS may be considered for the treatment of IED without the risk of neurovegetative side effects.
Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction
Authors: Mühlenkamp Melanie C. , Hallström Teresia , Autenrieth Ingo B. , Bohn Erwin , Linke Dirk , Rinker Janina , Riesbeck Kristian , Singh Birendra , Leo Jack C. , Hammerschmidt Sven , Zipfel Peter F. , Schütz Monika S.
Published: October 2016

Complement resistance is an important virulence trait of Yersinia enterocolitica (Ye). The predominant virulence factor expressed by Ye is Yersinia adhesin A (YadA), which enables bacterial attachment to host cells and extracellular matrix and additionally allows the acquisition of soluble serum factors. The serum glycoprotein vitronectin (Vn) acts as an inhibitory regulator of the terminal complement complex by inhibiting the lytic pore formation. Here, we show YadA-mediated direct interaction of Ye with Vn and investigated the role of this Vn binding during mouse infection in vivo. Using different Yersinia strains, we identified a short stretch in the YadA head domain of Ye O:9 E40, similar to the ‘uptake region' of Y. pseudotuberculosis YPIII YadA, as crucial for efficient Vn binding. Using recombinant fragments of Vn, we found the C-terminal part of Vn, including heparin-binding domain 3, to be responsible for binding to YadA. Moreover, we found that Vn bound to the bacterial surface is still functionally active and thus inhibits C5b-9 formation. In a mouse infection model, we demonstrate that Vn reduces complement-mediated killing of Ye O:9 E40 and, thus, improved bacterial survival. Taken together, these findings show that YadA-mediated Vn binding influences Ye pathogenesis.
Level of Vascular Endothelial Growth Factor in the Vitreous Fluid of Proliferative Diabetic Retinopathy Patients and Prognosis after Vitrectomy
Authors: Suzuki Yukihiko , Suzuki Kaori , Kudo Takashi , Metoki Tomomi , Nakazawa Mitsuru
Published: October 2016

Purpose: The aim of this study was to evaluate the relationship between the intravitreal vascular endothelial growth factor (VEGF) level and prognosis of proliferative diabetic retinopathy (PDR). Methods: The study involved 136 eyes of 114 PDR patients who underwent an initial vitrectomy between 2006 and 2008. Intravitreal VEGF levels were determined using Bio-Plex® (Bio-Rad), with levels of 5,000 pg/mL or more classified as high-VEGF (45 eyes) and levels lower than 5,000 pg/mL as low-VEGF (91 eyes). Diabetic control, PDR severity, and frequency of postoperative complications were compared between the groups. Results: There was no significant difference in preoperative status between the groups. In the low-VEGF group, a reoperation was required due to postoperative complications in 2 eyes (2.2%); 1 with vitreous hemorrhage (VH) and 1 with retinal detachment (RD). In contrast, a reoperation was required in 8 eyes (17.8%) in the high-VEGF group; 3 with VH, 2 with RD, and 3 with neovascular glaucoma. The difference between the groups was significant. There was a statistically lower postoperative corrected visual acuity logMAR (6 months after surgery) in the high-VEGF than in the low-VEGF group (p = 0.02, unpaired t test). Conclusion: Current findings indicate that careful observation is needed in patients with elevated VEGF levels.
Adaptive Cross-Resistance to Aminoglycoside Antibiotics in Pseudomonas aeruginosa Induced by Topical Dosage of Neomycin
Authors: Uemura Shuji , Yokota Shin-ichi , Shiraishi Tsukasa , Kitagawa Manabu , Hirayama Suguru , Kyan Ryoko , Mizuno Hirotoshi , Sawamoto Keigo , Inoue Hiroyuki , Miyamoto Atsushi , Narimatsu Eichi
Published: October 2016

Background: Topical antimicrobial formulations containing neomycin are commonly used to prevent and treat burn infections. However, Pseudomonas aeruginosa shows rapid acquisition of adaptive resistance to neomycin. This study aimed to evaluate the survival of P. aeruginosa during exposure to neomycin at high concentrations comparable to those used in topical formulations, and to investigate the effect of adaptive resistance to neomycin on the susceptibility to other aminoglycosides. Methods: Strain IID1130 [neomycin minimal inhibitory concentration (MIC) = 4 µg/ml] was incubated on an agar medium containing neomycin at high concentrations (8-4,096 µg/ml), and growing colonies were macroscopically observed. Acquisition of adaptive resistance was examined for 5 P. aeruginosa strains. Cells were sequentially passaged on agar medium containing neomycin with step-wise increased concentrations (8-2,048 µg/ml). To assess reversion of antibiotic susceptibility, the resulting colonies were repeatedly subcultured on antibiotic-free agar plates. Results: Growing IID1130 colonies were macroscopically detected on a neomycin-containing (2,048 µg/ml) agar plate for 48 h. These cells showed increasing MIC for not only neomycin, but also gentamicin and amikacin; the MIC values were occasionally higher than the breakpoints. When the adapted cells were subcultured on antibiotic-free agar, several passages were required for reversion of susceptibility. Conclusions: Our findings suggest that P. aeruginosa can survive in the presence of neomycin with a concentration typically used in topical dosage forms, and that the acquired adaptive resistance is persistent and is accompanied by cross-resistance to other aminoglycosides.
Prognostic Value of Pre- and Postoperative Anti-p53 Antibody Levels in Colorectal Cancer Patients: A Retrospective Study
Authors: Abe Shinya , Kawai Kazushige , Ishihara Soichiro , Nozawa Hiroaki , Hata Keisuke , Kiyomatsu Tomomichi , Tanaka Toshiaki , Nishikawa Takeshi , Ootani Kensuke , Yasuda Koji , Murono Koji , Watanabe Toshiaki
Published: October 2016

Objective: To determine the utility of the post-/preoperative anti-p53 antibody (p53 Ab) ratio as a prognostic factor for colorectal cancer (CRC) recurrence. Methods: A total of 737 nonmetastatic CRC patients who had undergone R0 resection were retrospectively analyzed. p53 Ab levels were measured within 1 month prior to and at least every 3 months after surgery. Post-/preoperative p53 Ab ratios were calculated, and the optimal ratio cutoff values for predicting recurrence were determined using the Kaplan-Meier method and the log-rank test. Results: Preoperative p53 Ab elevation was observed in 194 patients (pre-p53 high). Preoperative p53 Ab levels correlated with TNM stage. Re-elevation of p53 Ab levels occurred on recurrence in the pre-p53 high group, but not in the pre-p53 low group (n = 543). In the pre-p53 high group, patients who experienced tumor recurrence exhibited a slow postoperative reduction of p53 Ab levels, and a post-/preoperative p53 Ab ratio >0.4 at postoperative 3 months predicted relapse-free survival. In other words, a p53 Ab level remaining higher than 40% of the preoperative level was an independent and strong risk factor for recurrence in multivariate analyses. Conclusion: In CRC patients with preoperative p53 Ab elevation, the rate of p53 Ab reduction in the early postsurgical period is a promising prognostic factor for recurrence.
Identifying CNVs in 15q11q13 and 16p11.2 of Patients with Seizures Increases the Rates of Detecting Pathogenic Changes
Authors: Vianna Gabrielle S. , Freitas Mariana L. , de Oliveira Valdirene T. , Pietra Rafaella X. , da S. Gonçalves Michele , Rocha Patrícia P.O. , Monteiro Rejane A.C. , Ferreira Luana C.A. , Xavier Rosana R. , Carvalho Andréia M. , de M. Lima Patrícia R. , Monteiro Maria Augusta N.P. , Mateo Elvis C. , Giannetti Juliana G. , da C. César Giovana , de S. Lima Joziele , Medeiros Paula F.V. , Jehee Fernanda S.
Published: October 2016

Chromosomal changes are frequently observed in patients with syndromic seizures. Understanding the genetic etiology of this pathology is crucial for the guidance and genetic counseling of families as well as for the establishment of appropriate treatment. A combination of MLPA kits was used to identify pathogenic CNVs in a group of 70 syndromic patients with seizures. Initially, a screening was performed for subtelomeric changes (MLPA P036 and P070 kits) and for the regions most frequently related to microdeletion/microduplication syndromes (MLPA P064). Subsequently, the MLPA P343 was used to identify alterations in the 15q11q13, 16p11.2, and 22q13 regions. Screening with MLPA P343 allowed a 10-15.7% increase in the detection rate of CNVs reinforcing the importance of investigating changes in 15q11q13 and 16p11.2 in syndromic patients with seizures. We also demonstrated that the MLPA technique is an alternative with a great diagnostic potential, and we proposed its use as part of the initial assessment of syndromic patients with seizures.
Get a Grip: Substrate Orientation and Digital Grasping Pressures in Strepsirrhines
Authors: Congdon Kimberly A. , Ravosa Matthew J.
Published: October 2016

Skeletal functional morphology in primates underlies many fossil interpretations. Understanding the functional correlates of arboreal grasping is central to identifying locomotor signatures in extinct primates. We tested 3 predictions linking substrate orientation and digital grasping pressures: (1) below-branch pressures are greater than above-branch and vertical-branch pressures; (2) there is no difference in pressure exerted across digits within autopods at any substrate orientation, and (3) there is no difference in pressure exerted between homologous digits across autopods at any substrate orientation. Adult males and females from 3 strepsirrhine species crossed an artificial arboreal substrate oriented for above-, below- and vertical-branch locomotion. We compared digital pressures within and across behaviors via ANOVA and Tukey's Honest Significant Difference test. Results show limited support for all predictions: below-branch pressures exceeded vertical-branch pressures and above-branch pressures for some digits and species (prediction 1), lateral digits often exerted greater pressures than medial digits (prediction 2), and pedal digits occasionally exerted greater pressures than manual digits during above-branch and vertical orientations but less often for below-branch locomotion (prediction 3). We observed functional variability across autopods, substrate and species that could underlie morphological variation within and across primates. Future work should consider the complexity of arboreality when inferring locomotor modes in fossils.
Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report
Authors: Misaka Kenji , Kishimoto Takashi  , Kawahigashi Yuji , Sata Michio , Nagao Yumiko
Published: October 2016

Hepatitis C virus (HCV) is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA) are highly effective and safe for the eradication of HCV. However, there is a lack of information regarding the association between HCV-associated OLP and interferon (IFN)-free DAA therapy. Herein, we present the case of a 60-year-old female who was diagnosed with OLP during routine periodontal treatment by a dentist. The patient was referred for hepatitis C treatment using IFN-free DAA, which resulted in the improvement of the symptoms of OLP. This case represents the safety and efficacy of IFN-free DAAs in patients with HCV-associated OLP. However, long-term follow-up studies are required to elucidate the therapeutic effects of this therapy in these patients.
Late-Onset Langerhans Cell Histiocytosis with Cerebellar Ataxia as an Initial Symptom
Authors: Pyun Jung-Min , Park Hyeyoung , Moon Kyung Chul , Jeon Beomseok
Published: October 2016

Late-onset progressive cerebellar ataxia is a diagnostic challenge because of a poor correlation between genotype and phenotype, and a broad range of secondary causes that extend beyond the neurological field. We report the case of a 45-year-old woman admitted after 2 years of slowly progressing cerebellar ataxia, dysarthria, and emotional instability. Notably, she was diagnosed with diabetes insipidus at the age of 35. As ‘idiopathic cerebellar ataxia’ was suspected, diagnostic tests, including genetic testing as well as serum and cerebrospinal fluid analyses, and brain magnetic resonance imaging (MRI) were performed. All results were normal except those of MRI, performed 9 months prior to admission, which showed multiple dot-like white matter lesions with unclear cause. On a repeated brain MRI, a new lesion presenting as a 1.5-cm-sized highly enhancing mass attached to the right frontal skull was found. A sharply marginated lytic skull defect was also evident on skull X-ray, which corresponded to the lesion mass. Given these new radiological findings, a systemic review of the patient’s medical history for rare secondary causes of cerebellar ataxia was performed, with particular attention to her past ‘diabetes insipidus’. The mass, lytic lesion of the skull, white matter lesion, diabetes insipidus, and cerebellar ataxia all suggested a final diagnosis of Langerhans cell histiocytosis (LCH), which was confirmed histopathologically. This is a rare case of late-onset LCH with an unusual initial symptom which underlines the importance of carefully reviewing the patient’s medical history and broadening the search for etiologies beyond the nervous system.
Sex Reversal in Reptiles: Reproductive Oddity or Powerful Driver of Evolutionary Change?
Authors: Holleley Clare E. , Sarre Stephen D. , O'Meally Denis , Georges Arthur
Published: October 2016

Is sex a product of genes, the environment, or both? In this review, we describe the diversity of sex-determining mechanisms in reptiles, with a focus on systems that display gene-environment interactions. We summarise the field and laboratory-based evidence for the occurrence of environmental sex reversal in reptiles and ask whether this is a widespread evolutionary mechanism affecting the evolution of sex chromosomes and speciation in vertebrates. Sex determination systems exist across a continuum of genetic and environmental influences, blurring the lines between what was once considered a strict dichotomy between genetic sex determination and temperature-dependent sex determination. Across this spectrum, we identify the potential for sex reversal in species with clearly differentiated heteromorphic sex chromosomes (Pogona vitticeps, Bassiana duperreyi, Eremias multiocellata, Gekko japonicus), weakly differentiated homomorphic sex chromosomes (Niveoscincus ocellatus), and species with only a weak heritable predisposition for sex (Emys orbicularis, Trachemys scripta). We argue that sex reversal is widespread in reptiles (Testudines, Lacertidae, Agamidae, Scincidae, Gekkonidae) and has the potential to have an impact on individual fitness, resulting in reproductively, morphologically, and behaviourally unique phenotypes. Sex reversal is likely to be a powerful evolutionary force responsible for generating and maintaining lability and diversity in reptile sex-determining modes.
Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes
Authors: Archabald Karen L. , Buhimschi Irina A. , Bahtiyar Mert O. , Dulay Antonette T. , Abdel-Razeq Sonya S. , Pettker Christian M. , Lipkind Heather S. , Hardy John T. , McCarthy Megan E. , Zhao Guomao , Bhandari Vineet , Buhimschi Catalin S.
Published: October 2016

Background: To improve neonatal outcomes in pregnancies at heightened risk for early-onset neonatal sepsis (EONS), there is a need to identify fetuses that benefit from expectant management as opposed to early delivery. Detectable haptoglobin and haptoglobin-related protein (Hp&HpRP switch-on status) in cord blood has been proposed as a biomarker of antenatal exposure to intra-amniotic infection and/or inflammation (IAI), an important determinant of EONS. Subjects and Methods: We analyzed 185 singleton newborns delivered secondary to preterm premature rupture of membranes (PPROM). In 123 cases, amniocentesis was performed to exclude amniotic fluid (AF) infection. Delivery was indicated for 61 cases with confirmed infection. Women without AF infection (n = 62) and those without amniocentesis (n = 62) were managed expectantly. Interleukin 6 and Hp&HpRP switch-on status were evaluated by ELISA and Western blot. Newborns were followed prospectively for short-term outcomes until hospital discharge or death. Results: Newborns exposed antenatally to IAI had an increased risk of adverse neonatal outcome [OR: 3.0 (95% CI: 1.15-7.59)]. Increasing gestational age [OR: 0.61 (95% CI: 0.52-0.70)] and management with amniocentesis [OR: 0.37 (95% CI: 0.14-0.95)] lowered the newborn's risk of developing adverse outcomes. Discussion: In the setting of PPROM and IAI, early delivery benefits a select subgroup of fetuses that have not yet progressed to Hp&HpRP switch-on status.
Impact of Cognitive Function Change on Mortality in Renal Transplant and End-Stage Renal Disease Patients
Authors: Sharma Akhil , Yabes Jonathan , Al Mawed Saleem , Wu Christine , Stilley Carol , Unruh Mark , Jhamb Manisha
Published: October 2016

Background: Limited evidence from small-scale studies, mainly involving end-stage renal disease (ESRD) patients, suggests that kidney transplantation may improve cognitive function. We examined changes in cognitive function after a kidney transplant and its association with survival in advanced chronic kidney disease (CKD)/ESRD patients. Methods: In a prospective study design, cognitive performance of 90 patients (50.6 ± 13.1 years, 66.7% men, 27.8% blacks, 76% CKD stages 4-5) was assessed at the respective patients' residences using established neurocognitive tests. Results: Among the 90 patients, 44 received a kidney transplant (KTx group) while 46 did not (no-KTx group). After a mean follow-up of ∼19 months, there was no significant change in scores for majority of cognitive tests in either group. Older age, but not diabetes or renal function status (CKD vs. ESRD), was a determinant of poor follow-up cognitive performance. Additionally, poor attention/psychomotor speed and executive performance (as measured by Trails A and Stroop test, respectively) was associated with higher mortality over a mean follow-up of 4.7 years, even after adjustment for age, sex, diabetes, CKD or ESRD status and kidney transplant status. Conclusion: Overall, cognitive function does not significantly improve after kidney transplant or significantly decline in non-transplanted, advanced CKD/ESRD patients. Poor attention, psychomotor speed and executive performance independent of transplant status were associated with higher mortality over time.
Idarucizumab as Antidote to Intracerebral Hemorrhage under Treatment with Dabigatran
Authors: Held Valentin , Eisele Philipp , Eschenfelder Christoph C. , Szabo Kristina
Published: October 2016

Background and Purpose: Non-vitamin K anticoagulants (NOAC) such as dabigatran have become important therapeutic options for the prevention of stroke. Until recently, there were only nonspecific agents to reverse their anticoagulant effects in a case of emergency. Idarucizumab, an antibody fragment targeting dabigatran, is the first specific antidote for a NOAC to be approved, but real-world experience is limited. Methods: We report two cases of patients on dabigatran with acute intracerebral hemorrhage who received idarucizumab. Results: In both cases, idarucizumab promptly reversed the anticoagulant effect of dabigatran and there was no hematoma expansion in follow-up imaging. Conclusions: In addition to clinical and preclinical studies, our cases add to the experience regarding the safety and efficacy of idarucizumab. They show that idarucizumab may be an important safety option for patients on dabigatran in emergency situations.
A Rare Cause of Pulmonary Nodules
Authors: Chew Michael Tsuyoshi , Chak Eric , Matsukuma Karen
Published: October 2016

Crohn’s disease is a chronic, idiopathic autoimmune disorder that primarily targets the gastrointestinal (GI) system. It is characterized by transmural inflammation of the GI tract that can occur anywhere from the mouth to the anus. Not infrequently, the disease may also have extraintestinal manifestations (EIMs) that can affect almost any organ system. It is estimated that EIMs affect up to 36% of patients with Crohn’s disease, but the incidence and prevalence of pulmonary involvement are variable in the literature and may be as low as 0.4%. There are few case reports documenting pulmonary manifestations, as they are often overlooked, especially if respiratory symptoms are present before the diagnosis of GI manifestations, as in the present case. A 44-year-old otherwise healthy woman presented with nonspecific respiratory complaints, recurrent pneumonias, and multiple computed tomography images showing diffuse, migratory, nodular, and consolidative parenchymal lung disease, with a largely unremarkable infectious and rheumatologic evaluation. Lung biopsy revealed necrotizing and nonnecrotizing granulomas, raising concern for sarcoidosis. Subsequent imaging revealed an incidental mass in the cecum. Biopsy of the cecum lesion revealed acute cryptitis, crypt abscess, and a single poorly formed granuloma, suggesting the possibility of Crohn’s disease. In this report, we present a patient whose pulmonary manifestations ultimately led to the diagnosis of Crohn’s disease.
Diagnosis and Clinical Management of Ruptured Ileocecal Pouches for Continent Cutaneous Urinary Diversion
Authors: Kalogirou Charis , Kocot Arkadius , Mulfinger Philipp , Hartmann Elena , Krebs Markus , Vergho Daniel , Riedmiller Hubertus
Published: October 2016

Background and Objectives: The study aimed to report on pouch ruptures in 5 patients with ileocecal reservoirs for continent cutaneous urinary diversion. Patients and Methods: Five male patients aged 48-89 were referred to our department between 2000 and 2016 with a ruptured ileocecal pouch 16-175 months postoperatively. Results: With an incidence of 0.95% in our series (5 ruptures in 529 pouch patients out of a pool of 1,182 radical cystectomies) a rupture of the ileocecal pouch is a rare but severe complication. In all the cases, the rupture was supported by the over-distension of the reservoir, while a traumatic self-catheterization was reported in 2 patients. The rupture occurred on the right lateral wall of the ileocecal pouch in 4 out of 5 cases and led to acute abdominal pain and inflammation. Pouchography was performed in all the patients and revealed a leakage in 4 of them. The rupture was verified intraoperatively in 1 patient. Open surgical exploration, drainage and repair were successfully performed in all 5 cases. Conclusions: Early diagnosis and immediate intervention are mandatory in the cases of pouch rupture to manage this severe complication, which is often related to reduction in patient compliance. Consequently, it is essential to raise awareness of this potentially life-threatening complication in patients with ileocecal pouches.
Comparison of YAG Laser Lithotripsy and Extracorporeal Shock Wave Lithotripsy in Treatment of Ureteral Calculi: A Meta-Analysis
Authors: Yang Chao , Li Shijun , Cui Yingdong
Published: October 2016

Objective: To evaluate the clinical efficiency and safety of ureteroscopy lithotripsy (URSL) with holmium laser technology and extracorporeal shock wave lithotripsy (ESWL) on ureteral calculi using systematic reviews. Methods: Randomized controlled trials and prospective controlled trials accorded with inclusion among PubMed Database, EmBase Database, Cochrane Library and China National Knowledge Infrastructure were collected. Review Manager 5.0 was adopted to estimate the effects of the results among selected articles. Forest plots, sensitivity analysis and bias analysis for the articles included were also conducted. Pooled estimate of risk ratios and standard mean difference (SMD) with 95% CIs were used as measures of effect sizes. Results: Finally 1,770 patients were included in the 14 studies, which eventually satisfied the eligibility criteria. The number of patients in URSL group and ESWL group were 885 and 885, respectively. The results of heterogeneity test suggested that complication events (RR 1.12 (95% CI 0.63-2.00), p = 0.70), hospital days (SMD = -0.08 (95% CI -1.14 to 0.98), p = 0.88) and efficiency quotient (RR 1.31 (95% CI 0.96-1.80), p = 0.09) were insignificantly different, while the stone-free rate (RR 1.15 (95% CI 1.06-1.26), p = 0.002) and operation time (SMD = -2.27 (95% CI -3.42 to -1.11), p = 0.0001) between ESWL and URSL were significantly different. Conclusion: Although both URSL and ESWL have its own advantages and drawbacks, URSL is relatively a more efficient and safe method to treat ureteric stones, since it has shorter operation time and a better stone-free rate.
Humanismo e Didática da História
Authors: Ehrlich Michel
Published: October 2016

Resenha de RÜSEN, Jorn. Humanismo e Didática da História. Organização e Tradução: Maria Auxiliadora Schmidt, Isabel Barca, Marcelo Fronza, Lucas Pydd Neci. Curitiba: W.A. Editores, 2015.
Defibrillators
Authors: Al-Khatib Sana M. , Friedman Paul , Ellenbogen Kenneth A.
Published: October 2016

Advances in the field of defibrillation have brought to practice different types of devices that include the transvenous implantable cardioverter-defibrillator (ICD) with or without cardiac resynchronization therapy, the subcutaneous ICD (S-ICD), and the wearable cardioverter-defibrillator. To ensure optimal use of these devices and to achieve best patient outcomes, clinicians need to understand how these devices work, learn the characteristics of patients who qualify them for one type of device versus another, and recognize the remaining gaps in knowledge surrounding these devices. The transvenous ICD has been shown in several randomized clinical trials to improve the survival of patients resuscitated from near-fatal ventricular fibrillation and those with sustained ventricular tachycardia with syncope or systolic heart failure as a result of ischemic or nonischemic cardiomyopathy despite receiving guideline-directed medical therapy. Important gaps in knowledge regarding the transvenous ICD involve the role of the ICD in patient subgroups not included, or not well represented, in clinical trials and the need to refine the selection criteria for the ICD in patients who are indicated for it. S-ICDs were recently introduced into the clinical arena as another option for many patients who have an approved indication for a transvenous ICD. The main advantage of the S-ICD is a lower risk of infection and lead-related complications; however, the S-ICD does not offer bradycardia or antitachycardia pacing. The S-ICD may be ideal for patients with limited vascular access, high infection risk, or some congenital heart diseases. However, more data are needed regarding the efficacy and effectiveness of the S-ICD in comparison to transvenous ICDs, the extent of defibrillation testing required, and the use of the S-ICD with other novel technologies, including leadless pacemakers. Cardiac resynchronization therapy-defibrillators are indicated in patients with a left ventricular ejection fraction ≤35%, QRS width ≥130 ms, and New York Heart Association class II, III, or ambulatory IV symptoms despite treatment with guideline-directed medical therapy. Multiple randomized controlled trials have shown that the cardiac resynchronization therapy-defibrillator improves survival, quality of life, and several echocardiographic measures. One main challenge related to cardiac resynchronization therapy-defibrillators is the 30% nonresponse rate. Many initiatives are underway to address this challenge including improved cardiac resynchronization therapy and imaging technologies and enhanced selection of patients and device programming.
Digital Critics: The Early History of Online Art Criticism
Authors: Frost Charlotte
Published: October 2016

Art critic Jerry Saltz is regarded as a pioneer of online art criticism by the mainstream press, yet the Internet has been used as a platform for art discussion for over 30 years. There have been studies of independent print-based arts publishing, online art production and electronic literature, but there have been no histories of online art criticism. In this article, the author provides an account of the first wave of online art criticism (1980–1995) to document this history and prepare the way for thorough evaluations of the changing form of art criticism after the Internet.
A-me and BrainCloud: Art-Science Interrogations of Localization in Neuroscience
Authors: Puig Jordi , Carusi Annamaria , Cassinelli Alvaro , Pinel Philippe , Hoel Aud Sissel
Published: October 2016

This article reports on two art-science collaborations, A-me: Augmented Memories and BrainCloud, that interrogate the central role of localization in neuroscience—including the use of technologies that augment sociability using localization as a central reference point. The two projects result from a series of interactions where a science/technology development fostered art, which in turn led to a science application, which potentially may lead to further artistic activity. A-me is an art installation that repurposes navigation and visualization tools normally reserved for medical clinicians and scientists, inviting reflection on the ongoing endeavor of neuroscience to explain and map cognitive functions such as memory. BrainCloud is a software prototype that provides neuroscientists with an interface for interacting with existing data and knowledge about the brain. Organized visually as a brain atlas, it forms a social network that allows neuroscientists to connect and share their ongoing research and ideas.
Hermeneutics: Between Faith and Reason
Authors: Davey Nicholas
Published: October 2016

Using the notion of the “in-between (Ins-Zwischen) as its primary focus, this paper argues that whereas hermeneutic practice has customarily been deployed to better understand the claims of religious texts, once hermeneutic practice itself becomes the object of understanding, then the practice emerges in its own right as a discipline for occasioning meditative thinking. How hermeneutic practice transforms itself into such a vehicle is the subject of this paper.
Karl Popper on the Unknown Logic of Artistic Production and Creative Discovery
Authors: Naraniecki Alexander
Published: October 2016

In the field of artistic research there has recently been a resurgence of interest in Karl Popper’s thought on scientific methodology. However, the current literature on artistic research has tended to reduce his methodological thought to the arguments in his book The Logic of Scientific Discovery (1959). Although greatly influential, this book does not represent Popper’s “mature” or later arguments. This article provides an alternative view of Popper better suited to debates on creativity and discovery. Contrary to his popularity in political and scientific circles, the relation of Popper’s arguments to the arts is less well known and has not seriously been studied, despite his profound influence on the art historian Ernst Gombrich. This article points out ways in which Popper’s thought can continue to contribute to the current debates on artistic research and creative production. It does this by disclosing the way in which his later writings on evolutionary epistemology and theory of objective knowledge, otherwise called the “World 3 Thesis,” can contribute to the field of artistic research.
A Short Improvisation on Milan Kundera’s Slowness
Authors: Raveh Daniel
Published: October 2016

Krishnachandra Bhattacharyya’s improvisations, or rather his interpretation as improvisation (of classical Indian texts, thinkers, schools of thought and concepts, as well as of the work of Immanuel Kant), inspires my own improvisation on Milan Kundera’s 1996 novel Slowness (La lenteur, 1995). Not only do I attempt to improvise, or to “interfere creatively” (apropos the Sanskrit notion of svīkaraṇa) in Kundera’s work, but moreover, I argue that this is exactly how he himself works in Slowness with Vivant Denon’s 1777 novella No Tomorrow (Point de lendemain). Reading Kundera, as I do here, with and through Indian theory, from the 7th or 8th century poet Rājaśekhara to contemporary thinkers such as Bhattacharyya, Daya Krishna, Mukund Lath and others, is not a standard move. However, it enables me to contemplate “in action” about the possibilities and impossibilities of a cross-cultural dialogue, as a potent tool of interpretation.
A new species of the genus Bothrioplana (Platyhelminthes: Bothrioplanida: Bothrioplanidae) and a new species of the genus Pentacoelum (Tricladida: Bdellouridae) from southern China
Authors: HE YI , ZHAO JIA-QI , NING WAN-RU , ZHUANG JIE-YI , ZHANG YU , WANG AN-TAI
Published: October 2016

Two new species of turbellarians, Bothrioplana sinensis n. sp., and Pentacoelum sinensis n. sp., were described based on their reproductive behavior, ontogenic development, morphology in whole-mounted and sectioned specimens, and 18S rDNA phylogenetic classification. Bothrioplana sinensis n. sp. represents a newly recorded order in China and the second identified species in the genus Bothrioplana. It is characterized by a pair of spherical-shaped well-developed testes located dorsally behind the pharynx, and the common vas deference located ventrally to the gonopore. Phylogenetic analysis showed that this new species is closely related to parasitic flatworms. Pentacoelum sinensis n. sp. is characterized by two uteri instead of lateral bursae located laterally near the tail end and a lack of connection between the posterior intestinal branches. Each uterus has a ventral receptaculum seminalis (also functioning as bursa copulatrix) which has a muscular vagina externa opening obliquely to the ventral side at the tail end.
Ankerius aenigmaticus, a new genus and new species of aphanodactylid crab symbiotic with polychaetes from the Red Sea coast of Saudi Arabia (Crustacea: Decapoda: Brachyura: Aphanodactylidae)
Authors: NG PETER K. L. , RAHAYU DWI LISTYO , SHIH HSI-TE
Published: October 2016

A new genus and new species of pinnotheroid crab of the family Aphanodactylidae, Ankerius aenigmaticus n. sp., is described from the Red Sea coast of Saudi Arabia. The genus is unusual among aphanodactylids in possessing more gaping third maxillipeds, strongly spiniform chelipeds and ambulatory legs, as well as a relatively longer ambulatory dactylus.
First description and bionomic notes for the final-instar larva and pupa of an Oriental dobsonfly species, Neoneuromus sikkimmensis (van der Weele, 1907) (Megaloptera: Corydalidae)
Authors: CAO CHENGQUAN , TONG CHAO , CHEN SHENGZHI , LIU ZHIWEI , XU FAQIONG , LIU QIAN , LIU XINGYUE
Published: October 2016

Neoneuromus van der Weele, 1909, a member of megalopteran subfamily Corydalinae, is a common and widespread dobsonfly genus of the Oriental Region. The adult taxonomy of Neoneuromus is relatively well-known but the larvae and pupae are undescribed. In this paper we describe the last-instar larva and the pupa of N. sikkimmensis (van der Weele, 1907), representing the first detailed description of any immature stage of Neoneuromus. Information on the bionomics of this species is also reported.
ENSO Precipitation and Temperature Forecasts in the North American Multimodel Ensemble: Composite Analysis and Validation
Authors: Chen Li-Chuan , van den Dool Huug , Becker Emily , Zhang Qin
Published: October 2016

In this study, precipitation and temperature forecasts during El Niño–Southern Oscillation (ENSO) events are examined in six models in the North American Multimodel Ensemble (NMME), including the CFSv2, CanCM3, CanCM4, the Forecast-Oriented Low Ocean Resolution (FLOR) version of GFDL CM2.5, GEOS-5, and CCSM4 models, by comparing the model-based ENSO composites to the observed. The composite analysis is conducted using the 1982–2010 hindcasts for each of the six models with selected ENSO episodes based on the seasonal oceanic Niño index just prior to the date the forecasts were initiated. Two types of composites are constructed over the North American continent: one based on mean precipitation and temperature anomalies and the other based on their probability of occurrence in a tercile-based system. The composites apply to monthly mean conditions in November, December, January, February, and March as well as to the 5-month aggregates representing the winter conditions. For anomaly composites, the anomaly correlation coefficient and root-mean-square error against the observed composites are used for the evaluation. For probability composites, a new probability anomaly correlation measure and a root-mean probability score are developed for the assessment. All NMME models predict ENSO precipitation patterns well during wintertime; however, some models have large discrepancies between the model temperature composites and the observed. The fidelity is greater for the multimodel ensemble as well as for the 5-month aggregates. February tends to have higher scores than other winter months. For anomaly composites, most models perform slightly better in predicting El Niño patterns than La Niña patterns. For probability composites, all models have superior performance in predicting ENSO precipitation patterns than temperature patterns.
Reexamination of the Wave Activity Envelope Convective Scheme in Theoretical Modeling of MJO
Authors: Chen Guosen , Wang Bin
Published: October 2016

The skeleton model is one of the theoretical models for understanding the essence of the Madden–Julian oscillation (MJO). The heating parameterization scheme in the skeleton model assumes that precipitation tendency is in phase and proportional to the low-level moisture anomaly. The authors show that the observed MJO precipitation tendency is not in phase with the low-level moisture anomaly. The consequence of the wave activity envelope (WAE) scheme is reexamined by using a general MJO theoretical framework in which trio-interaction among convective heating, moisture, and wave–boundary layer (BL) dynamics are included and various simplified convective schemes can be accommodated. Without the BL dynamics, the general model framework can be reduced to the original skeleton model. The authors show that the original skeleton model yields a neutral mode that exhibits a “quadrupole” horizontal structure and a quadrature relationship between precipitation and low-level moisture; both are inconsistent with observations. With the BL dynamics and damping included, the model can produce a growing mode with improved horizontal structure and precipitation–moisture relationship, but deficiencies remain because of the WAE scheme. The authors further demonstrate that the general model with the simplified Betts–Miller scheme and BL dynamics can produce a realistic horizontal structure (coupled Kelvin–Rossby wave structure) and precipitation–moisture relationship (i.e., the BL moisture convergence leads precipitation, and column-integrated moisture coincides with precipitation).
Atmospheric Water Balance and Variability in the MERRA-2 Reanalysis
Authors: Bosilovich Michael G. , Robertson Franklin R. , Takacs Lawrence , Molod Andrea , Mocko David
Published: October 2016

Closing and balancing Earth’s global water cycle remains a challenge for the climate community. Observations are limited in duration, global coverage, and frequency, and not all water cycle terms are adequately observed. Reanalyses aim to fill the gaps through the assimilation of as many atmospheric water vapor observations as possible. Former generations of reanalyses have demonstrated a number of systematic problems that have limited their use in climate studies, especially regarding low-frequency trends. This study characterizes the NASA Modern-Era Retrospective Analysis for Research and Applications version 2 (MERRA-2) water cycle relative to contemporary reanalyses and observations. MERRA-2 includes measures intended to minimize the spurious global variations related to inhomogeneity in the observational record. The global balance and cycling of water from ocean to land is presented, with special attention given to the water vapor analysis increment and the effects of the changing observing system. While some systematic regional biases can be identified, MERRA-2 produces temporally consistent time series of total column water and transport of water from ocean to land. However, the interannual variability of ocean evaporation is affected by the changing surface-wind-observing system, and precipitation variability is closely related to the evaporation. The surface energy budget is also strongly influenced by the interannual variability of the ocean evaporation. Furthermore, evaluating the relationship of temperature and water vapor indicates that the variations of water vapor with temperature are weaker in satellite data reanalyses, not just MERRA-2, than determined by observations, atmospheric models, or reanalyses without water vapor assimilation.
Spatial and Temporal Network Sampling Effects on the Correlation and Variance Structures of Rain Observations
Authors: Jameson A. R.
Published: October 2016

Network observations are affected by the length of the temporal interval over which measurements are combined as well as by the size of the network. When the observation interval is small, only network size matters. Networks then act as high-pass filters that distort both the spatial correlation function ρr and, consequently, the variance spectrum. For an exponentially decreasing ρr, a method is presented for returning the observed spatial correlation to its original, intrinsic value. This can be accomplished for other forms of ρr. When the observation interval becomes large, however, advection enhances the contributions from longer wavelengths, leading to a distortion of ρr and the associated variance spectrum. However, there is no known way to correct for this effect, which means that the observation interval should be kept as small as possible in order to measure the spatial correlation correctly. Finally, it is shown that, in contrast to network measurements, remote sensing instruments act as low-pass filters, thus complicating comparisons between the two sets of observations. It is shown that when the network-observed spatial correlation function can be corrected to become a good estimate of the intrinsic spatial correlation function, the Fourier transform of this function (variance spectrum) can then be spatially low-pass filtered in a manner appropriate for the remote sensor. If desired, this filtered field can then be Fourier transformed to yield the spatial correlation function relevant to the remote sensor. The network and simulations of the remote sensor observations can then be compared to better understand the physics of differences between the two set of observations.
Le partenariat en recherche
Authors: Gélinas Isabelle
Published: October 2016

Description.

Les partenariats en ergothérapie entre les praticiens et les chercheurs sont importants pour produire des connaissances pertinentes pour la pratique clinique et pour favoriser la pratique fondée sur les données probantes au sein de la profession.

But.

Dans ce discours Muriel Driver, l’auteure discute des raisons pour lesquelles nous devons favoriser la participation des praticiens à la recherche et elle examine les conditions essentielles à la réussite des partenariats de recherche en collaboration.

Questions clés.

Les partenariats de collaboration peuvent réduire les obstacles empêchant les praticiens de participer à la recherche et permettre de veiller à ce que les initiatives de recherche soient plus pertinentes pour la pratique clinique. Les facteurs clés pour établir et maintenir des partenariats significatifs sont la présence de conditions préalables et favorables au partenariat en lien avec le contexte, de même que l’utilisation de principes directeurs axés sur la vision, les valeurs, la confiance, la communication, le partage du pouvoir et les interactions.

Conséquences.

Plusieurs des facteurs identifiés comme étant favorables à la réussite d’un partenariat de collaboration correspondent aux rôles fondamentaux des ergothérapeutes et témoignent de nos valeurs professionnelles. La prise en compte de ces facteurs lors de l’établissement de collaborations de recherche permettrait d’accroître les probabilités de réussite.
The right network for the right problem
Authors: Gomez Louis M. , Russell Jennifer L. , Bryk Anthony S. , LeMahieu Paul G. , Mejia Eva M.
Published: October 2016

Educators are realizing that individuals working in isolation can’t adequately address the teaching and learning problems that face us today. Collective action networks are needed. Sharing networks use collective energy to support individual action and agency, whereas execution networks typically address complex problems that require sustained collective action to resolve. One kind of execution network -- networked improvement communities (NIC) -- can be of great value to educators as they tackle complex problems of practice. The story of the formation of the Mathematics Teacher Education Partnership (MTEP) illustrates how catalyzing a NIC is different from forming a sharing community and why a formal infrastructure is required for sustained collective action.
Getting better together
Authors: MacConnell Kristen , Caillier Stacey
Published: October 2016

At High Tech Elementary Chula Vista in California, teachers are using improvement science, a method for solving a problem of practice with disciplined inquiry, to help students make their thinking visible. The teachers wanted to increase students’ use of how and why language to articulate their thinking; to that end, they’ve been using short cycles of inquiry, action, and reflection to test different change ideas. The teachers found that improvement science fosters reflective practice, helps teachers take action, and facilitates collaboration and sharing.
A better research-practice partnership
Authors: Henrick Erin , Munoz Marco A. , Cobb Paul
Published: October 2016

District leaders often feel that working with researchers is not mutually beneficial. Researchers don’t provide enough practical guidance, and they’re often unable to present their findings in time to inform district decision making. Research-practice partnerships (RPPs) are a potential new strategy for addressing these challenges. RPPs are long-term, mutual collaborations between practitioners and researchers that are organized to investigate problems of practice and solutions for improving district outcomes. By focusing on real-time district challenges, RPPs can lead to research that is informative, timely, and relevant to district stakeholders.