bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolomic Analysis Evidences That Uterine Epithelial Cells Enhance Blastocyst Development in a Microfluidic Device
Authors: Mancini Vanessa , Schrimpe-Rutledge Alexandra C. , Codreanu Simona G. , Sherrod Stacy D. , McLean John A. , Picton Helen M. , Pensabene Virginia
Published: May 2021

Here we report the use of a microfluidic system to assess the differential metabolomics of murine embryos cultured with endometrial cells-conditioned media (CM). Groups of 10, 1-cell murine B6C3F1 × B6D2F1 embryos were cultured in the microfluidic device. To produce CM, mouse uterine epithelial cells were cultured in potassium simplex optimized medium (KSOM) for 24 h. Media samples were collected from devices after 5 days of culture with KSOM (control) and CM, analyzed by reverse phase liquid chromatography and untargeted positive ion mode mass spectrometry analysis. Blastocyst rates were significantly higher (p < 0.05) in CM (71.8%) compared to control media (54.6%). We observed significant upregulation of 341 compounds and downregulation of 214 compounds in spent media from CM devices when compared to control. Out of these, 353 compounds were identified showing a significant increased abundance of metabolites involved in key metabolic pathways (e.g., arginine, proline and pyrimidine metabolism) in the CM group, suggesting a beneficial effect of CM on embryo development. The metabolomic study carried out in a microfluidic environment confirms our hypothesis on the potential of uterine epithelial cells to enhance blastocyst development. Further investigations are required to highlight specific pathways involved in embryo development and implantation.
Current Trends in Polymer Based Sensors
Authors: Alberti Giancarla , Zanoni Camilla , Losi Vittorio , Magnaghi Lisa Rita , Biesuz Raffaela
Published: May 2021

This review illustrates various types of polymer and nanocomposite polymeric based sensors used in a wide variety of devices. Moreover, it provides an overview of the trends and challenges in sensor research. As fundamental components of new devices, polymers play an important role in sensing applications. Indeed, polymers offer many advantages for sensor technologies: their manufacturing methods are pretty simple, they are relatively low-cost materials, and they can be functionalized and placed on different substrates. Polymers can participate in sensing mechanisms or act as supports for the sensing units. Another good quality of polymer-based materials is that their chemical structure can be modified to enhance their reactivity, biocompatibility, resistance to degradation, and flexibility.
Depressive Symptomatology and Parenting Stress: Influence on the Social-Emotional Development of Pre-Schoolers in Chile
Authors: Santelices María Pía , Tagle Francisca , Immel Nina
Published: May 2021

(1) Background: The preschool stage is a period of great psychological changes that requires the support of parents and significant adults for optimal development. Studies show that maternal mental health can be a risk factor in parenting, affecting the social-emotional development of children. (2) Methods: The present study seeks to shed light on the relation between depressive symptoms, parental stress in mothers and social-emotional development of their preschool children, using a total of 123 mother-child dyads with low Social-economic Status (SES). In mothers, depressive symptomatology and level of parental stress were evaluated, as well as social-emotional development in children. A possible mediation effect between maternal depressive symptoms and parenting stress is expected. (3) Results: The results indicate that higher levels of depressive symptoms and parenting stress in mothers relate to greater difficulties in social-emotional development of their preschool children. (4) Conclusions: These results are clinically relevant from the perspective of family therapy: Parents need support to decrease their levels of parenting stress in order not to jeopardise their children’s social-emotional development.
Rejuvenation Mechanism of Asphalt Mixtures Modified with Crumb Rubber
Authors: Noorvand Hossein , Kaloush Kamil , Medina Jose , Underwood Shane
Published: May 2021

Asphalt aging is one of the main factors causing asphalt pavements deterioration. Previous studies reported on some aging benefits of asphalt rubber mixtures through laboratory evaluation. A field observation of various pavement sections of crumb rubber modified asphalt friction courses (ARFC) in the Phoenix, Arizona area indicated an interesting pattern of transverse/reflective cracking. These ARFC courses were placed several years ago on existing jointed plain concrete pavements for highway noise mitigation. Over the years, the shoulders had very noticeable and extensive cracking over the joints; however, the driving lanes of the pavement showed less cracking formation in severity and extent. The issue with this phenomenon is that widely adopted theories that stem from continuum mechanics of materials and layered mechanics of pavement systems cannot directly explain this phenomenon. One hypothesis could be that traffic loads continually manipulate the pavement over time, which causes some maltenes (oils and resins) compounds absorbed in the crumb rubber particles to migrate out leading to rejuvenation of the mastic in the asphalt mixture. To investigate the validity of such a hypothesis, an experimental laboratory testing was undertaken to condition samples with and without dynamic loads at high temperatures. This was followed by creep compliance and indirect tensile strength testing. The results showed the higher creep for samples aged with dynamic loading compared to those aged without loading. Higher creep compliance was attributed to higher flexibility of samples due to the rejuvenation of the maltenes. This was also supported by the higher fracture energy results obtained for samples conditioned with dynamic loading from indirect tensile strength testing.
Utility of CMV-Specific Immune Monitoring for the Management of CMV in Solid Organ Transplant Recipients: A Clinical Update
Authors: Prakash Katya , Chandorkar Aditya , Saharia Kapil K.
Published: May 2021

Cytomegalovirus (CMV) is one of the most important opportunistic infections in solid organ transplant (SOT) recipients. However, current techniques used to predict risk for CMV infection fall short. CMV-specific cell mediated immunity (CMI) plays an important role in protecting against CMV infection. There is evidence that assays measuring CMV-CMI might better identify SOT recipients at risk of complications from CMV compared to anti-CMV IgG, which is our current standard of care. Here, we review recently published studies that utilize CMV-CMI, at various points before and after transplantation, to help predict risk and guide the management of CMV infection following organ transplantation. The evidence supports the use of these novel assays to help identify SOT recipients at increased risk and highlights the need for larger prospective trials evaluating these modalities in this high-risk population.
Student Perceptions of a Synchronous Online Cooperative Learning Course in a Japanese Women’s University during the COVID-19 Pandemic
Authors: Sugino Chie
Published: May 2021

As the coronavirus disease 2019 (COVID-19) pandemic expanded worldwide, most Japanese universities launched online learning as an emergent measure; hence, securing the quality of online learning remains a challenge. This study aimed to understand reasons behind students’ preferred mode of online learning during the pandemic and to explore the impact of online cooperative learning on students’ class participation by analyzing their voluntary comments. A qualitative content analysis identified three factors that are related to students’ decisions and motivation about participating in synchronous online classes: mutuality resulting from interaction, the impact of COVID-19 on their life and learning, and individual circumstances. This small-scale study was conducted under the unusual circumstance of the pandemic, and the quality of student interaction was excluded from the analysis. However, their enjoyment arising from interaction encouraged their participation in a synchronous class and discussion. They expressed themselves and listened to others attentively, creating a favorable climate for learning. Students’ positive interdependence observed in this study suggests that cooperative learning cultivates a classroom culture where students are willing to contribute without the fear of losing face. This study indicated that participation, cooperation, and active engagement create a positive feedback loop, promoting each aspect even in an online setting.
A Study on Persistence of GAN-Based Vision-Induced Gustatory Manipulation
Authors: Nakano Kizashi , Horita Daichi , Kawai Norihiko , Isoyama Naoya , Sakata Nobuchika , Kiyokawa Kiyoshi , Yanai Keiji , Narumi Takuji
Published: May 2021

Vision-induced gustatory manipulation interfaces can help people with dietary restrictions feel as if they are eating what they want by modulating the appearance of the alternative foods they are eating in reality. However, it is still unclear whether vision-induced gustatory change persists beyond a single bite, how the sensation changes over time, and how it varies among individuals from different cultural backgrounds. The present paper reports on a user study conducted to answer these questions using a generative adversarial network (GAN)-based real-time image-to-image translation system. In the user study, 16 participants were presented somen noodles or steamed rice through a video see-through head mounted display (HMD) both in two conditions; without or with visual modulation (somen noodles and steamed rice were translated into ramen noodles and curry and rice, respectively), and brought food to the mouth and tasted it five times with an interval of two minutes. The results of the experiments revealed that vision-induced gustatory manipulation is persistent in many participants. Their persistent gustatory changes are divided into three groups: those in which the intensity of the gustatory change gradually increased, those in which it gradually decreased, and those in which it did not fluctuate, each with about the same number of participants. Although the generalizability is limited due to the small population, it was also found that non-Japanese and male participants tended to perceive stronger gustatory manipulation compared to Japanese and female participants. We believe that our study deepens our understanding and insight into vision-induced gustatory manipulation and encourages further investigation.
User State Classification Based on Functional Brain Connectivity Using a Convolutional Neural Network
Authors: Park Seung-Min , Yeom Hong-Gi , Sim Kwee-Bo
Published: May 2021

The brain–computer interface (BCI) is a promising technology where a user controls a robot or computer by thinking with no movement. There are several underlying principles to implement BCI, such as sensorimotor rhythms, P300, steady-state visually evoked potentials, and directional tuning. Generally, different principles are applied to BCI depending on the application, because strengths and weaknesses vary according to each BCI method. Therefore, BCI should be able to predict a user state to apply suitable principles to the system. This study measured electroencephalography signals in four states (resting, speech imagery, leg-motor imagery, and hand-motor imagery) from 10 healthy subjects. Mutual information from 64 channels was calculated as brain connectivity. We used a convolutional neural network to predict a user state, where brain connectivity was the network input. We applied five-fold cross-validation to evaluate the proposed method. Mean accuracy for user state classification was 88.25 ± 2.34%. This implies that the system can change the BCI principle using brain connectivity. Thus, a BCI user can control various applications according to their intentions.
An Innovative Tunable Rule-Based Strategy for the Predictive Management of Hybrid Microgrids
Authors: Moretti Luca , Meraldi Lorenzo , Niccolai Alessandro , Manzolini Giampaolo , Leva Sonia
Published: May 2021

This work proposes a methodology for the optimal training of rule-based management strategies, to be directly implemented in the industrial controller of hybrid off-grid microgrids. The parameters defining the control rules are optimally tuned resorting to different evolutionary algorithms, based on the expected operating conditions. The performance of the resulting management heuristics is compared with conventional approaches to optimal scheduling, including Mixed Integer Linear Programming (MILP) optimization, direct evolutionary scheduling optimization, and traditional non-trained heuristics. Results show how the trained heuristics achieve a performance very close to the global optimum found by the MILP solution, outperforming the other methods, and providing a single-layer commitment and dispatch algorithm which is easily deployable in the microgrid controller.
A Review on Speech Emotion Recognition Using Deep Learning and Attention Mechanism
Authors: Lieskovská Eva , Jakubec Maroš , Jarina Roman , Chmulík Michal
Published: May 2021

Emotions are an integral part of human interactions and are significant factors in determining user satisfaction or customer opinion. speech emotion recognition (SER) modules also play an important role in the development of human–computer interaction (HCI) applications. A tremendous number of SER systems have been developed over the last decades. Attention-based deep neural networks (DNNs) have been shown as suitable tools for mining information that is unevenly time distributed in multimedia content. The attention mechanism has been recently incorporated in DNN architectures to emphasise also emotional salient information. This paper provides a review of the recent development in SER and also examines the impact of various attention mechanisms on SER performance. Overall comparison of the system accuracies is performed on a widely used IEMOCAP benchmark database.
K-MDTSC: K-Multi-Dimensional Time-Series Clustering Algorithm
Authors: Giordano Danilo , Mellia Marco , Cerquitelli Tania
Published: May 2021

The increasing capability to collect data gives us the possibility to collect a massive amount of heterogeneous data. Among the heterogeneous data available, time-series represents a mother lode of information yet to be fully explored. Current data mining techniques have several shortcomings while analyzing time-series, especially when more than one time-series, i.e., multi-dimensional timeseries, should be analyzed together to extract knowledge from the data. In this context, we present K-MDTSC (K-Multi-Dimensional Time-Series Clustering), a novel clustering algorithm specifically designed to deal with multi-dimensional time-series. Firstly, we demonstrate K-MDTSC capability to group multi-dimensional time-series using synthetic datasets. We compare K-MDTSC results with k-Shape, a state-of-art time-series clustering algorithm based on K-means. Our results show both K-MDTSC and k-Shape create good clustering results. However, K-MDTSC outperforms k-Shape when complicating the synthetic dataset. Secondly, we apply K-MDTSC in a real case scenario where we are asked to replace a scheduled maintenance with a predictive approach. To this end, we create a generalized pipeline to process data from a real industrial plant welding process. We apply K-MDTSC to create clusters of weldings based on their welding shape. Our results show that K-MDTSC identifies different welding profiles, but that the aging of the electrode does not negatively impact the welding process.
Cyber Third-Party Risk Management: A Comparison of Non-Intrusive Risk Scoring Reports
Authors: Keskin Omer F. , Caramancion Kevin Matthe , Tatar Irem , Raza Owais , Tatar Unal
Published: May 2021

Cybersecurity is a concern for organizations in this era. However, strengthening the security of an organization’s internal network may not be sufficient since modern organizations depend on third parties, and these dependencies may open new attack paths to cybercriminals. Cyber Third-Party Risk Management (C-TPRM) is a relatively new concept in the business world. All vendors or partners possess a potential security vulnerability and threat. Even if an organization has the best cybersecurity practice, its data, customers, and reputation may be at risk because of a third party. Organizations seek effective and efficient methods to assess their partners’ cybersecurity risks. In addition to intrusive methods to assess an organization’s cybersecurity risks, such as penetration testing, non-intrusive methods are emerging to conduct C-TPRM more easily by synthesizing the publicly available information without requiring any involvement of the subject organization. In this study, the existing methods for C-TPRM built by different companies are presented and compared to discover the commonly used indicators and criteria for the assessments. Additionally, the results of different methods assessing the cybersecurity risks of a specific organization were compared to examine reliability and consistency. The results showed that even if there is a similarity among the results, the provided security scores do not entirely converge.
Enhancement of Ship Type Classification from a Combination of CNN and KNN
Authors: Jeon Ho-Kun , Yang Chan-Su
Published: May 2021

Ship type classification of synthetic aperture radar imagery with convolution neural network (CNN) has been faced with insufficient labeled datasets, unoptimized and noised polarization images that can deteriorate a classification performance. Meanwhile, numerous labeled text information for ships, such as length and breadth, can be easily obtained from various sources and can be utilized in a classification with k-nearest neighbor (KNN). This study proposes a method to improve the efficiency of ship type classification from Sentinel-1 dual-polarization data with 10 m pixel spacing using both CNN and KNN models. In the first stage, Sentinel-1 intensity images centered on ship positions were used in a rectangular shape to apply an image processing procedure such as head-up, padding and image augmentation. The process increased the accuracy by 33.0% and 31.7% for VH (vertical transmit and horizontal receive) and VV (vertical transmit and vertical receive) polarization compared to the CNN-based classification with original ship images, respectively. In the second step, a combined method of CNN and KNN was compared with a CNN-alone case. The f1-score of CNN alone was up to 85.0%, whereas the combination method showed up to 94.3%, which was a 9.3% increase. In the future, more details on an optimization method will be investigated through field experiments of ship classification.
The Influence of Land Use Change on Key Ecosystem Services and Their Relationships in a Mountain Region from Past to Future (1995–2050)
Authors: Gao Jie , Tang Xuguang , Lin Shiqiu , Bian Hongyan
Published: May 2021

The ecosystem services (ESs) provided by mountain regions can bring about benefits to people living in and around the mountains. Ecosystems in mountain areas are fragile and sensitive to anthropogenic disturbance. Understanding the effect of land use change on ESs and their relationships can lead to sustainable land use management in mountain regions with complex topography. Chongqing, as a typical mountain region, was selected as the site of this research. The long-term impacts of land use change on four key ESs (i.e., water yield (WY), soil conservation (SC), carbon storage (CS), and habitat quality (HQ)) and their relationships were assessed from the past to the future (at five-year intervals, 1995–2050). Three future scenarios were constructed to represent the ecological restoration policy and different socioeconomic developments. From 1995 to 2015, WY and SC experienced overall increases. CS and HQ increased slightly at first and then decreased significantly. A scenario analysis suggested that, if the urban area continues to increase at low altitudes, by 2050, CS and HQ are predicted to decrease moderately. However, great improvements in SC, HQ, and CS are expected to be achieved by the middle of the century if the government continues to make efforts towards vegetation restoration on the steep slopes.
Biomass Conversion: Fermentation Chemicals and Fuels
Authors: Kalogiannis Konstantinos G.
Published: May 2021

Rendezvous with Rama [...]
Dry-Aged Beef Steaks: Effect of Dietary Supplementation with Pinus taeda Hydrolyzed Lignin on Sensory Profile, Colorimetric and Oxidative Stability
Authors: Maggiolino Aristide , Sgarro Maria Federica , Natrella Giuseppe , Lorenzo Josè Manuel , Colucci Annamaria , Faccia Michele , De Palo Pasquale
Published: May 2021

Flavor is one of the main factors involved in consumer meat-purchasing decision and use of natural antioxidants in animal feeding had a great appeal for consumers. The aim of this trial is to evaluate the effect of Pinus taeda hydrolyzed lignin (PTHL) feed addition on oxidative stability, volatile compounds characteristics, and sensory attributes of 35 days dry-aged beef steaks. Forty steer six months old were randomly divided into a control group (CON; n = 20) and an experimental group (PTHL; n = 20). Both groups were fed ad libitum for 120 days with the same TMR and only the PTHL group received PTHL supplement. Samples of LT muscle were removed from carcasses and dry aged for 35 days at 2 °C, 82% of humidity, and 0.4 m/s of ventilation and then analyzed. Meat of CON group showed lower yellowness (p < 0.01) and higher TBARS (p < 0.01) values. Moreover, CON meat showed higher volatile aldehydes and lower sulfur compounds (p < 0.01), with higher unpleasant odor (p < 0.05) and meaty odor (p < 0.01) score revealed by sensory assessors. PTHL inclusion in beef diet delayed the oxidative mechanisms in 35 days dry-aged steaks, resulting in an improved colorimetric, volatolomic, and sensory profile.
Effect of an Antibacterial Polysaccharide Produced by Chaetomium globosum CGMCC 6882 on the Gut Microbiota of Mice
Authors: Sun Xincheng , Wang Zichao , Hu Xuyang , Zhao Chengxin , Zhang Xiaogen , Zhang Huiru
Published: May 2021

Previously, a polysaccharide produced by Chaetomiumglobosum CGMCC 6882 was found to have antibacterial activity, but its toxic effects on body health and gut microbiota were concealed. Recent results showed that this polysaccharide was safe to Caco-2 cells and mice, while it reduced the body weight gain of mice from 10.5 ± 1.21 g to 8.4 ± 1.17 g after 28 days administration. Acetate, propionate, butyrate and total short-chain fatty acids concentrations increased from 23.85 ± 1.37 μmol/g, 10.23 ± 0.78 μmol/g, 7.15 ± 0.35 μmol/g and 41.23 ± 0.86 μmol/g to 42.77 ± 1.29 μmol/g, 20.03 ± 1.44 μmol/g, 12.06 ± 0.51 μmol/g and 74.86 ± 2.07 μmol/g, respectively. Furthermore, this polysaccharide enriched the abundance of gut microbiota and the Firmicutes/Bacteroidetes ratio was increased from 0.5172 to 0.7238. Overall, this study provides good guidance for the promising application of polysaccharides as preservatives in foods and in other fields in the future.
Endoscopic Evaluation and Therapeutic Considerations of Small Bowel Crohn’s Disease
Authors: Banerjee Rupa , Pal Partha
Published: May 2021

Small bowel evaluation is warranted in all newly diagnosed cases of Crohn’s disease (CD) as small bowel is involved in two-thirds of CD patients at diagnosis and the involvement can be discontinuous. Endoscopic evaluation of the small bowel in suspected or established CD can be done by video capsule endoscopy (VCE), device assisted enteroscopy (DAE) (which includes single and double balloon enteroscopy, novel motorized spiral enteroscopy (NMSE) and balloon guided endoscopy (BGE)) and intra-operative enteroscopy (IOE). In suspected CD with a negative ileo-colonoscopy, VCE is the preferred initial diagnostic modality in the absence of obstructive symptoms or known stenosis. VCE should be preceded by cross-sectional imaging or patency capsule testing if obstruction is suspected given with high retention risk. In established cases, small bowel cross-sectional imaging (magnetic resonance or computed tomography enterography) is preferred over VCE as it can assess transmural and extra-luminal involvement. VCE is indicated subsequently if necessary to assess disease extent, unexplained symptoms (e.g., anemia, malnutrition) or mucosal healing. Pan-enteric capsule endoscopy (PCE) and the use of artificial intelligence are the recent developments with VCE. DAE with small bowel biopsy can provide definitive evidence of CD including the extent and severity. A final diagnosis of CD is based on the constellation of clinical, radiologic, histologic and endoscopic features. Newer technologies like NMSE and BGE can help with deeper and faster small bowel evaluation. DAE has also allowed endoscopic treatment of small bowel strictures, small bowel bleeding and retrieval of retained capsule or foreign bodies. Endoscopic balloon dilation (EBD), endoscopic electro-incision, strictureplasty and stenting have shown promising results in CD related small bowel strictures. In conclusion, endoscopic evaluation of the small bowel is rapidly evolving field that has a major role in diagnosis and management of small bowel CD and can alter treatment outcomes in properly selected patients.
Editorial: “Evolutionary Genetics of Insect Innate Immunity”
Authors: Eleftherianos Ioannis
Published: May 2021

The insect innate immune system is under strong selection pressure to evolve resistance to pathogenic infections [...]
Craniofacial Diseases Caused by Defects in Intracellular Trafficking
Authors: Lu Chung-Ling , Kim Jinoh
Published: May 2021

Cells use membrane-bound carriers to transport cargo molecules like membrane proteins and soluble proteins, to their destinations. Many signaling receptors and ligands are synthesized in the endoplasmic reticulum and are transported to their destinations through intracellular trafficking pathways. Some of the signaling molecules play a critical role in craniofacial morphogenesis. Not surprisingly, variants in the genes encoding intracellular trafficking machinery can cause craniofacial diseases. Despite the fundamental importance of the trafficking pathways in craniofacial morphogenesis, relatively less emphasis is placed on this topic, thus far. Here, we describe craniofacial diseases caused by lesions in the intracellular trafficking machinery and possible treatment strategies for such diseases.
The ATM Gene in Breast Cancer: Its Relevance in Clinical Practice
Authors: Stucci Luigia Stefania , Internò Valeria , Tucci Marco , Perrone Martina , Mannavola Francesco , Palmirotta Raffaele , Porta Camillo
Published: May 2021

Molecular alterations of the Ataxia-telangiectasia (AT) gene are frequently detected in breast cancer (BC), with an incidence ranging up to 40%. The mutated form, the Ataxia-telangiectasia mutated (ATM) gene, is involved in cell cycle control, apoptosis, oxidative stress, and telomere maintenance, and its role as a risk factor for cancer development is well established. Recent studies have confirmed that some variants of ATM are associated with an increased risk of BC development and a worse prognosis. Thus, many patients harboring ATM mutations develop intermediate- and high-grade disease, and there is a higher rate of lymph node metastatic involvement. The evidence concerning a correlation of ATM gene mutations and the efficacy of therapeutic strategies in BC management are controversial. In fact, ATM mutations may sensitize cancer cells to platinum-derived drugs, as BRCA1/2 mutations do, whereas their implications in objective responses to hormonal therapy or target-based agents are not well defined. Herein, we conducted a review of the role of ATM gene mutations in BC development, prognosis, and different treatment strategies.
Identification and Validation of Reference Genes for Gene Expression Analysis in Schima superba
Authors: Yang Zhongyi , Zhang Rui , Zhou Zhichun
Published: May 2021

Real-time quantitative PCR (RT-qPCR) is a reliable and high-throughput technique for gene expression studies, but its accuracy depends on the expression stability of reference genes. Schima superba is a fast-growing timber species with strong resistance. However, thus far, reliable reference gene identifications have not been reported in S. superba. In this study, 19 candidate reference genes were selected and evaluated for their expression stability in different tissues of S. superba. Three software programs (geNorm, NormFinder, and BestKeeper) were used to evaluate the reference gene transcript stabilities, and comprehensive stability ranking was generated by the geometric mean method. Our results show that SsuACT was the most stable reference gene and that SsuACT + SsuRIB was the best reference gene combination for different tissues. Finally, the stable and less stable reference genes were verified using SsuSND1 expression in different tissues. To our knowledge, this is the first report to verify appropriate reference genes for normalizing gene expression in S. superba for different tissues, which will facilitate the future elucidation of gene regulations in this species and useful references for relative species.
Long-COVID Syndrome? A Study on the Persistence of Neurological, Psychological and Physiological Symptoms
Authors: Orrù Graziella , Bertelloni Davide , Diolaiuti Francesca , Mucci Federico , Di Giuseppe Mariagrazia , Biella Marco , Gemignani Angelo , Ciacchini Rebecca , Conversano Ciro
Published: May 2021

Background: Emerging aspects of the Covid-19 clinical presentation are its long-term effects, which are characteristic of the so-called “long COVID”. The aim of the present study was to investigate the prevalence of physical, psychological, and sleep disturbances and the quality of life in the general population during the ongoing pandemic. Methods: This study, based on an online survey, collected demographic data, information related to COVID-19, sleep disturbances, and quality of life data from 507 individuals. The level of sleep disturbances and quality of life was assessed through the Insomnia Severity Index (ISI) and the EuroQol-5D (EQ-5D), respectively. Results: In total, 507 individuals (M = 91 and F = 416 women) completed the online survey. The main symptoms associated with “long COVID” were headache, fatigue, muscle aches/myalgia, articular pains, cognitive impairment, loss of concentration, and loss of smell. Additionally, the subjects showed significant levels of insomnia (p < 0.05) and an overall reduced quality of life (p < 0.05). Conclusions: The results of the study appear in line with recent publications, but uncertainty regarding the definition and specific features of “long COVID” remains. Further studies are needed in order to better define the clinical presentation of the “long COVID” condition and related targeted treatments.
Association between Anticholinergic Burden and Constipation: A Systematic Review
Authors: Rodríguez-Ramallo Héctor , Báez-Gutiérrez Nerea , Prado-Mel Elena , Alfaro-Lara Eva Rocío , Santos-Ramos Bernardo , Sánchez-Fidalgo Susana
Published: May 2021

The association between anticholinergic burden and constipation is not well defined and documented; for this reason, a systematic review was carried out in five databases (Medline, Embase, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus), including studies assessing the correlation between anticholinergic burden, and constipation between January 2006 and December 2020. Data extraction was conducted independently by two researchers. Abstracts and titles were reviewed to determine eligibility for review with eligible articles read in full. From 2507 identified articles, 11 were selected for this review: six cross-sectional studies, four retrospective cohort studies, and a post hoc analysis of a randomized clinical trial. Overall, nine studies reported at least one statistical association between anticholinergic burden and constipation, finding 13 positive results out of 24 association measurements. A total of 211,921 patients were studied. The association between constipation and anticholinergic burden could be demonstrated in studies including 207,795 patients. Most studies were not designed to find differences in constipation prevalence and did not adjust the results by confounding factors. Our findings suggest that a correlation between anticholinergic burden and constipation exists. Higher quality-evidence studies are needed, including analysis that considers confounding factors, such as other non-pharmacological causes of constipation.
Anticoagulation for Splanchnic Vein Thrombosis in Myeloproliferative Neoplasms: The Drug and the Duration
Authors: Sedhom Wafik G. , Stein Brady Lee
Published: May 2021

Myeloproliferative neoplasms are a common cause of splanchnic vein thrombosis, which causes significant morbidity and mortality. Indefinite anticoagulation is the mainstay of therapy, and vitamin K antagonists (VKAs) are routinely used since hematologists have the most experience with this drug class. The role of direct oral anticoagulants (DOACs) is promising, but still undergoing evaluation. Cytoreduction with hydroxyurea or pegylated interferon is often used when cytosis is present, but their roles are yet to be defined when the complete blood count is normal. Janus kinase (JAK) inhibition may have a complementary role in reducing splenomegaly and portal hypertension.
Plant Production and Leaf Anatomy of Mertensia maritima (L.) Gray: Comparison of In Vitro Culture Methods to Improve Acclimatization
Authors: Copetta Andrea , Bazzicalupo Miriam , Cassetti Arianna , Marchioni Ilaria , Mascarello Carlo , Cornara Laura , Pistelli Laura , Ruffoni Barbara
Published: May 2021

Mertensia maritima is a commercially interesting herb with edible leaves and flowers, characterized by oyster flavor and taste. Plant propagation and traditional cultivation are challenging for this species. Therefore, the main purpose of the present study was to establish successful protocols aimed at ensuring oyster plant shoot propagation, rooting and in vivo acclimatization. Both micropropagation and rooting were tested, comparing the traditional in vitro solid substrate in jar vs. the liquid culture in a temporary immersion system (TIS) bioreactor (Plantform™). A Murashige and Skoog (MS) medium added with 4-μM thidiazuron (TDZ) and 1-μM α-naphthaleneacetic acid (NAA) was employed for micropropagation, while a half-strength MS medium supplemented with 4-μM indole−3-butyric acid (IBA) was used for rooting. Different acclimatization conditions in the greenhouse or in growth chamber were tested. Morphometric and microscopical analyses were performed on the oyster plant leaves at the propagation, rooting and acclimatization stages both in a jar and in a TIS. Micropropagation in a TIS allowed to obtain large shoots, while a great number of shoots was observed in the jar. M. maritima shoots rooted in TIS produced more developed roots, leaves with more developed waxy glands and well-formed stomata; moreover, the plants coming from the TIS showed the best acclimatization performances.
Interpersonal Support, Emotional Intelligence and Family Function in Adolescence
Authors: Barragán Martín Ana Belén , Molero Jurado María del Mar , Pérez-Fuentes María del Carmen , Oropesa Ruiz Nieves Fátima , Martos Martínez África , Simón Márquez María del Mar , Gázquez Linares José Jesús
Published: May 2021

Background: During adolescence, although the peer group exerts a strong influence on how the individual thinks and feels and on personal social values, the family still exerts a sustaining and supporting role. This study analyzed the relationships established between family function, emotional intelligence and perceived interpersonal support in adolescence. Method: The sample was made up of 1287 high school students aged 14 to 18 (M = 15.11; SD = 0.91) in the province of Almeria (Spain). Results: The results showed moderate correlations between the intrapersonal emotional intelligence dimension and perceived availability of support (advice or orientation), and between the mood dimension of emotional intelligence and the three interpersonal support dimensions (appraisal, belonging and tangible). In addition, significant positive correlations were found between family function and the intrapersonal and mood dimensions of emotional intelligence, with medium and large effect sizes, respectively. Apart from that, the data revealed that students who could count on a more functional family referred to high empathy and acceptance by others and greater support in material or financial matters, followed by those with moderate family function. In addition, students from homes with severely dysfunctional families perceived less available support. Finally, students who said they could count on strong family function also scored higher on the intrapersonal factor of emotional intelligence. Conclusions: The implications of these findings for the development of emotional intelligence in early adolescence are discussed from the family context, considering the relationship between emotional intelligence and social support.
Using an Activity Tracker in Healthcare: Experiences of Healthcare Professionals and Patients
Authors: Ummels Darcy , Beekman Emmylou , Braun Susy M. , Beurskens Anna J.
Published: May 2021

Despite the increased use of activity trackers, little is known about how they can be used in healthcare settings. This study aimed to support healthcare professionals and patients with embedding an activity tracker in the daily clinical practice of a specialized mental healthcare center and gaining knowledge about the implementation process. An action research design was used to let healthcare professionals and patients learn about how and when they can use an activity tracker. Data collection was performed in the specialized center with audio recordings of conversations during therapy, reflection sessions with the therapists, and semi-structured interviews with the patients. Analyses were performed by directed content analyses. Twenty-eight conversations during therapy, four reflection sessions, and eleven interviews were recorded. Both healthcare professionals and patients were positive about the use of activity trackers and experienced it as an added value. Therapists formulated exclusion criteria for patients, a flowchart on when to use the activity tracker, defined goals, and guidance on how to discuss (the data of) the activity tracker. The action research approach was helpful to allow therapists to learn and reflect with each other and embed the activity trackers into their clinical practice at a specialized mental healthcare center.
Non-Financial Support Provided to Parents in Stepfamilies: Empirical Examination of Europeans 50+
Authors: Kalbarczyk Małgorzata
Published: May 2021

The aging of the population, coupled with increasing divorce and remarriage rates, are changing the structure of potential non-financial support for older parents. The purpose of this study was to examine support provided to parents aged 50+ in stepfamilies and to determine if the difference existed between help provided by natural children and stepchildren. The primary objective was to investigate whether blood ties were a significant determinant of the support if the quality of the relationship between the parent and a natural child or a stepchild was taken into account. The secondary objective was to answer the question to what extent the reciprocal exchange motive of support was observed in stepfamilies. The probability of non-financial support from children and stepchildren was estimated based on the sixth wave of the SHARE (Survey on Health, Ageing, and Retirement in Europe) database for European countries. Children in stepfamilies provided less non-financial help to parents than those in intact families. Stepchildren were less likely to be in stepparents’ social networks, and stepparents provided less help with childcare for grandchildren than they did to their biological children. Relationship closeness and looking after grandchildren increased the probability of non-financial support to older parents, regardless of whether the donor was a natural child or a stepchild.
Sarcopenia, Exercise and Quality of Life
Authors: Mielgo-Ayuso Juan , Fernández-Lázaro Diego
Published: May 2021

The loss of strength, power, and muscle mass caused by the progressive deterioration from aging is known as “sarcopenia [...]
Description of Main Predictors for Taking Sick Leave Associated with Work-Related Eye Injuries in Spain
Authors: Martín-Prieto Sergio , Alvarez-Peregrina Cristina , Thuissard-Vassallo Israel , Catalina-Romero Carlos , Calvo-Bonacho Eva , Villa-Collar César , Sánchez-Tena Miguel Ángel
Published: May 2021

Recent studies in Spain have shown that males, younger workers, and people involved in manual jobs had the highest risk of suffering a work-related eye injury (WREI). This study aims to assess the predictors of sick leave associated with WREI and to compare them with risk factors of initial injury. A retrospective and descriptive study of WREI that causes sick leave of one or more days among workers from an insurance labor mutual company in Spain was conducted over a period from 2008 to 2018. The variables of the study were sex, age, occupation, and type of injury. A total of 9352 (18.6% of 50,265 WREI) cases and 113,395 total days of sick leave were observed, with an estimated EUR 4,994,009.59 of associated labor cost. The main predictors of sick leave related to WREI were found to be female (highest incidence; 25.9 (95% CI (24.8–27.1))), >55 years of age (highest incidence; 20.5 (95% CI (19.3–21.7))), not working in the industry (lowest incidence; 13.8 (95% CI (13.3–14.2))), and not suffering “other disorders of conjunctiva” (lowest incidence; 5.7 (95% CI (4.7–6.8))). The consequences associated with WREI are worse for female and older workers, despite the main risk of suffering WREI being observed in males and younger workers.
Resource Misallocation and Energy-Related Pollution
Authors: He Ling-Yun , Qi Xiao-Feng
Published: May 2021

Developing countries face the conflict between economic development and environmental protection. Resource misallocation will not only affect the effectiveness of economic development, but also have environmental impacts. Based on two large-scale enterprise databases in China, this paper measured the level of enterprise resource allocation, and further used empirical research methods to investigate the environmental impact of enterprise resource misallocation and specific mechanisms. The results show that the low efficiency of resource allocation will harm the quality of China’s environment. Further investigation, resource misallocation is accompanied by an increase in total energy input, a decrease in the labor-to-energy ratio and the capital-to-energy ratio, and a loss of energy efficiency, which in turn affects the environmental performance of enterprises. China is the largest developing country in the world, and research on China’s environmental and economic issues is important. The conclusions of this paper can provide experience and suggestions for other developing countries to improve environmental quality and promote sustainable development from the perspective of resource misallocation.
Promoting Interprofessional Education and Collaborative Practice in Rural Health Settings: Learnings from a State-Wide Multi-Methods Study
Authors: Martin Priya , Pighills Alison , Burge Vanessa , Argus Geoff , Sinclair Lynne
Published: May 2021

Evidence is mounting regarding the positive effects of Interprofessional Education and Collaborative Practice (IPECP) on healthcare outcomes. Despite this, IPECP is only in its infancy in several Australian rural healthcare settings. Whilst some rural healthcare teams have successfully adopted an interprofessional model of service delivery, information is scarce on the factors that have enabled or hindered such a transition. Using a combination of team surveys and individual semi-structured team member interviews, data were collected on the enablers of and barriers to IPECP implementation in rural health settings in one Australian state. Using thematic analysis, three themes were developed from the interview data: IPECP remains a black box; drivers at the system level; and the power of an individual to make or break IPECP. Several recommendations have been provided to inform teams transitioning from multi-disciplinary to interprofessional models of service delivery.
Soil Sample Assay Uncertainty and the Geographic Distribution of Contaminants: Error Impacts on Syracuse Trace Metal Soil Loading Analysis Results
Authors: Griffith Daniel A. , Chun Yongwan
Published: May 2021

A research team collected 3609 useful soil samples across the city of Syracuse, NY; this data collection fieldwork occurred during the two consecutive summers (mid-May to mid-August) of 2003 and 2004. Each soil sample had fifteen heavy metals (As, Cr, Cu, Co, Fe, Hg, Mo, Mn, Ni, Pb, Rb, Se, Sr, Zn, and Zr), measured during its assaying; errors for these measurements are analyzed in this paper, with an objective of contributing to the geography of error literature. Geochemistry measurements are in milligrams of heavy metal per kilogram of soil, or ppm, together with accompanying analytical measurement errors. The purpose of this paper is to summarize and portray the geographic distribution of these selected heavy metals measurement errors across the city of Syracuse. Doing so both illustrates the value of the SAAR software’s uncertainty mapping module and uncovers heavy metal characteristics in the geographic distribution of Syracuse’s soil. In addition to uncertainty visualization portraying and indicating reliability information about heavy metal levels and their geographic patterns, SAAR also provides optimized map classifications of heavy metal levels based upon their uncertainty (utilizing the Sun-Wong separability criterion) as well as an optimality criterion that simultaneously accounts for heavy metal levels and their affiliated uncertainty. One major outcome is a summary and portrayal of the geographic distribution of As, Cr, Cu, Co, Fe, Hg, Mo, Mn, Ni, Pb, Rb, Se, Sr, Zn, and Zr measurement error across the city of Syracuse.
Determinants of Successful Exclusive Breastfeeding for Saudi Mothers: Social Acceptance Is a Unique Predictor
Authors: Alyousefi Nada A
Published: May 2021

Recent guidelines motivate health care professionals to promote exclusive breastfeeding (EBF). The reported rate of EBF is low in Saudi Arabia. This study aimed to explore the determinants of successful exclusive breastfeeding for Saudi mothers. A cross-sectional, survey-based study was conducted in family medicine clinics. The dependent variable was the actual practice of EBF. Independent variables were the mothers’ demographic information, comfortableness with breastfeeding in public, knowledge and attitudes about breastfeeding, previous experience of successful breastfeeding, and a previous feeding plan. Statistical analysis was carried out using bivariate analysis and multinomial logistic regression. Out of the 322 respondents, only 28% practiced exclusive breastfeeding for the first six months. Perceived insufficient milk (p = 0.011) was associated with a lower EBF rate. Mothers’ degrees of comfort with breastfeeding in front of their relatives (p = 0.024) and in front of friends (p = 0.028) were significantly associated with their infants’ actual feeding practices for the first six months of their infants’ lives. Mothers reported that the absence of a suitable place for breastfeeding caused them to stop breastfeeding (p = 0.043) and was associated with their infant’s actual feeding practices for the first six months of their infant’s lives. An antenatal breastfeeding intention was considered a significant predictor of EBF; OR: 7.31 (95% CI: 2.24—23.84). Mothers who do not stop breastfeeding when they get sick have a 5.054 times higher chance of continuing EBF (95% CI: 1.037—24.627) than the formula-only feeding group. Thus, social acceptance is a unique predictor for their success in exclusive breastfeeding. Mothers have good intentions and a desire to breastfeed. Therefore, they must be guided through their pregnancy and postpartum period to overcome breastfeeding issues.