bluuebunny/crossref_metadata_2025 huggingface dataset:
Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats
Authors: Gabbia Daniela , Saponaro Miriam , Sarcognato Samantha , Guido Maria , Ferri Nicola , Carrara Maria , De Martin Sara
Published: January 2020

The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted from these seaweeds on the deposition of fat in the liver after the administration of a high-fat diet (HFD) to rats for five weeks. The administration of F. vesiculosus and A. nodosum led to significant reductions in microvescicular steatosis and plasma biochemical and lipid parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total and conjugated bilirubin, and triglycerides. Furthermore, the postprandial glycemic peak was delayed and significantly reduced (p < 0.01) by the algal extract administration. In conclusion, this extract is effective in reducing microvescicular steatosis and improving glycemic control, thereby lowering the risk of nonalcoholic fatty liver disease, obesity, and diabetes, diseases related to the consumption of fat and sugar-enriched diets.
Antifouling Napyradiomycins from Marine-Derived Actinomycetes Streptomyces aculeolatus
Authors: Pereira Florbela , Almeida Joana R. , Paulino Marisa , Grilo Inês R. , Macedo Helena , Cunha Isabel , Sobral Rita G. , Vasconcelos Vitor , Gaudêncio Susana P.
Published: January 2020

The undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and off-shore infrastructures. To date, there are no sustainable, cost-effective and environmentally safe solutions to address this challenging phenomenon. Therefore, we investigated the antifouling activity of napyradiomycin derivatives that were isolated from actinomycetes from ocean sediments collected off the Madeira Archipelago. Our results revealed that napyradiomycins inhibited ≥80% of the marine biofilm-forming bacteria assayed, as well as the settlement of Mytilus galloprovincialis larvae (EC50 < 5 µg/ml and LC50/EC50 >15), without viability impairment. In silico prediction of toxicity end points are of the same order of magnitude of standard approved drugs and biocides. Altogether, napyradiomycins disclosed bioactivity against marine micro and macrofouling organisms, and non-toxic effects towards the studied species, displaying potential to be used in the development of antifouling products.
Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment
Authors: Jones Mitchell , Kujundzic Marina , John Sabu , Bismarck Alexander
Published: January 2020

Chitin and its derivative chitosan are popular constituents in wound-treatment technologies due to their nanoscale fibrous morphology and attractive biomedical properties that accelerate healing and reduce scarring. These abundant natural polymers found in arthropod exoskeletons and fungal cell walls affect almost every phase of the healing process, acting as hemostatic and antibacterial agents that also support cell proliferation and attachment. However, key differences exist in the structure, properties, processing, and associated polymers of fungal and arthropod chitin, affecting their respective application to wound treatment. High purity crustacean-derived chitin and chitosan have been widely investigated for wound-treatment applications, with research incorporating chemically modified chitosan derivatives and advanced nanocomposite dressings utilizing biocompatible additives, such as natural polysaccharides, mineral clays, and metal nanoparticles used to achieve excellent mechanical and biomedical properties. Conversely, fungi-derived chitin is covalently decorated with -glucan and has received less research interest despite its mass production potential, simple extraction process, variations in chitin and associated polymer content, and the established healing properties of fungal exopolysaccharides. This review investigates the proven biomedical properties of both fungal- and crustacean-derived chitin and chitosan, their healing mechanisms, and their potential to advance modern wound-treatment methods through further research and practical application.
Lipoxygenase Pathways in Diatoms: Occurrence and Correlation with Grazer Toxicity in Four Benthic Species
Authors: Ruocco Nadia , Nuzzo Genoveffa , d’Ippolito Giuliana , Manzo Emiliano , Sardo Angela , Ianora Adrianna , Romano Giovanna , Iuliano Antonella , Zupo Valerio , Costantini Maria , Fontana Angelo
Published: January 2020

Oxygenated derivatives of fatty acids, collectively called oxylipins, are a highly diverse family of lipoxygenase (LOX) products well described in planktonic diatoms. Here we report the first investigation of these molecules in four benthic diatoms, Cylindrotheca closterium, Nanofrustulum shiloi, Cocconeis scutellum, and Diploneis sp. isolated from the leaves of the seagrass Posidonia oceanica from the Gulf of Naples. Analysis by hyphenated MS techniques revealed that C. closterium, N. shiloi, and C. scutellum produce several polyunsaturated aldehydes (PUAs) and linear oxygenated fatty acids (LOFAs) related to the products of LOX pathways in planktonic species. Diploneis sp. also produced other unidentified fatty acid derivatives that are not related to LOX metabolism. The levels and composition of oxylipins in the benthic species match their negative effects on the reproductive success in the sea urchin Paracentrotus lividus. In agreement with this correlation, the most toxic species N. shiloi revealed the same LOX pathways of Skeletonema marinoi and Thalassiosira rotula, two bloom-forming planktonic diatoms that affect copepod reproduction. Overall, our data highlight for the first time a major role of oxylipins, namely LOFAs, as info-chemicals for benthic diatoms, and open new perspectives in the study of the structuring of benthic communities.
A Pilot Study of Circulating Monocyte Subsets in Patients Treated with Stem Cell Transplantation for High-Risk Hematological Malignancies
Authors: Rundgren Ida Marie , Ersvær Elisabeth , Ahmed Aymen Bushra , Ryningen Anita , Bruserud Øystein
Published: January 2020

Background and Objectives: Autologous and allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies, and monocytes are probably involved in hematological reconstitution as well as posttransplant immunoregulation. The aim of our study was to investigate the levels of circulating monocyte subsets in allotransplant recipients. Materials and Methods: The levels of the classical, intermediate, and nonclassical monocyte subsets were determined by flow cytometry. Sixteen patients and 18 healthy controls were included, and the levels were analyzed during pretransplant remission (n = 13), early posttransplant during cytopenia (n = 9), and early reconstitution (n = 9). Results: Most patients in remission showed a majority of classical monocytes. The patients showed severe early posttransplant monocytopenia, but the total peripheral blood monocyte counts normalized very early on, and before neutrophil and platelet counts. During the first 7–10 days posttransplant (i.e., during cytopenia) a majority of the circulating monocytes showed a nonclassical phenotype, but later (i.e., 12–28 days posttransplant) the majority showed a classical phenotype. However, the variation range of classical monocytes was wider for patients in remission and during regeneration than for healthy controls. Conclusions: The total peripheral blood monocyte levels normalize at the very early stages and before neutrophil reconstitution after stem cell transplantation, and a dominance of classical monocytes is reached within 2–4 weeks posttransplant.
Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise—Searching for Gap Fillers in the Oxidative Stress Way of Thinking
Authors: Balmus Ioana-Miruna , Ilie Ovidiu-Dumitru , Ciobica Alin , Cojocariu Roxana-Oana , Stanciu Carol , Trifan Anca , Cimpeanu Mirela , Cimpeanu Cristian , Gorgan Lucian
Published: January 2020

Irritable bowel syndrome (IBS) remains to date an intriguing functional gastrointestinal disorder. Recent studies described a multitude of exogenous factors that work together in IBS, gradually impairing intestinal lining cellular metabolism, including oxidative status balance, with or without a genetic background. Although the current biomarkers support the differentiation between IBS subtypes and other functional gastrointestinal disorder, they are mostly non-specific, referring to clinical, biochemical, and inflammatory imbalances. Since IBS could be also the result of deficient signaling pathways involving both gastrointestinal secretion and neuro-vegetative stimulation, IBS makes no exception from the oxidative hypothesis in the pathological mechanisms. Regarding the oxidative stress implication in IBS, the previous research efforts showed controversial results, with some animal models and patient studies reporting clear oxidative imbalance both on systemic and local levels, but still with no concrete evidence to point to a direct correlation between oxidative stress and IBS. Additionally, it seems that a major role could be also attributed to gut microbiota and their ability to shape our bodies and behaviors. Moreover, the genetic features study in IBS patients showed that several genetic similarities point to a possible correlation of IBS with affective spectrum disorders. Thus, we focus here the discussion on the assumption that IBS could in fact be more likely a stress-related disorder rather than a gastrointestinal one.
Acknowledgement to Reviewers of Metals in 2019
Authors:   Metals Editorial Office
Published: January 2020

The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not [...]
Design, Modeling, Additive Manufacturing, and Polishing of Stiffness-Modulated Porous Nitinol Bone Fixation Plates Followed by Thermomechanical and Composition Analysis
Authors: Jahadakbar Ahmadreza , Nematollahi Mohammadreza , Safaei Keyvan , Bayati Parisa , Giri Govind , Dabbaghi Hediyeh , Dean David , Elahinia Mohammad
Published: January 2020

The use of titanium bone fixation plates is considered the standard of care for skeletal reconstructive surgery. Highly stiff titanium bone fixation plates provide immobilization immediately after the surgery. However, after the bone healing stage, they may cause stress shielding and lead to bone resorption and failure of the surgery. Stiffness-modulated or stiffness-matched Nitinol bone fixation plates that are fabricated via additive manufacturing (AM) have been recently introduced by our group as a long-lasting solution for minimizing the stress shielding and the follow-on bone resorption. Up to this point, we have modeled the performance of Nitinol bone fixation plates in mandibular reconstruction surgery and investigated the possibility of fabricating these implants. In this study, for the first time the realistic design of stiffness-modulated Nitinol bone fixation plates is presented. Plates with different levels of stiffness were fabricated, mechanically tested, and used for verifying the design approach. Followed by the design verification, to achieve superelastic bone fixation plates we proposed the use of Ni-rich Nitinol powder for the AM process and updated the models based on that. Superelastic Nitinol bone fixation plates with the extreme level of porosity were fabricated, and a chemical polishing procedure used to remove the un-melted powder was developed using SEM analysis. Thermomechanical evaluation of the polished bone fixation plates verified the desired superelasticity based on finite element (FE) simulations, and the chemical analysis showed good agreement with the ASTM standard.
Vertical Leakage in GaN-on-Si Stacks Investigated by a Buffer Decomposition Experiment
Authors: Tajalli Alaleh , Borga Matteo , Meneghini Matteo , De Santi Carlo , Benazzi Davide , Besendörfer Sven , Püsche Roland , Derluyn Joff , Degroote Stefan , Germain Marianne , Kabouche Riad , Abid Idriss , Meissner Elke , Zanoni Enrico , Medjdoub Farid , Meneghesso Gaudenzio
Published: January 2020

We investigated the origin of vertical leakage and breakdown in GaN-on-Si epitaxial structures. In order to understand the role of the nucleation layer, AlGaN buffer, and C-doped GaN, we designed a sequential growth experiment. Specifically, we analyzed three different structures grown on silicon substrates: AlN/Si, AlGaN/AlN/Si, C:GaN/AlGaN/AlN/Si. The results demonstrate that: (i) the AlN layer grown on silicon has a breakdown field of 3.25 MV/cm, which further decreases with temperature. This value is much lower than that of highly-crystalline AlN, and the difference can be ascribed to the high density of vertical leakage paths like V-pits or threading dislocations. (ii) the AlN/Si structures show negative charge trapping, due to the injection of electrons from silicon to deep traps in AlN. (iii) adding AlGaN on top of AlN significantly reduces the defect density, thus resulting in a more uniform sample-to-sample leakage. (iv) a substantial increase in breakdown voltage is obtained only in the C:GaN/AlGaN/AlN/Si structure, that allows it to reach VBD > 800 V. (v) remarkably, during a vertical I–V sweep, the C:GaN/AlGaN/AlN/Si stack shows evidence for positive charge trapping. Holes from C:GaN are trapped at the GaN/AlGaN interface, thus bringing a positive charge storage in the buffer. For the first time, the results summarized in this paper clarify the contribution of each buffer layer to vertical leakage and breakdown.
Genomic Analysis of Carbapenemase-Producing Extensively Drug-Resistant Klebsiella pneumoniae Isolates Reveals the Horizontal Spread of p18-43_01 Plasmid Encoding blaNDM-1 in South Africa
Authors: Ramsamy Yogandree , Mlisana Koleka P. , Allam Mushal , Amoako Daniel G. , Abia Akebe L. K. , Ismail Arshad , Singh Ravesh , Kisten Theroshnie , Swe Han Khine Swe , Muckart David J. Jackson , Hardcastle Timothy , Suleman Moosa , Essack Sabiha Y.
Published: January 2020

Whole-genome sequence (WGS) analyses were employed to investigate the genomic epidemiology of extensively drug-resistant Klebsiella pneumoniae strains, focusing on the carbapenem resistance-encoding determinants, mobile genetic support, clonal and epidemiological relationships. A total of ten isolates were obtained from patients admitted to the intensive care unit (ICU) in a public hospital in South Africa. Five isolates were from rectal swabs of colonized patients and five from blood cultures of patients with invasive carbapenem-resistant infections. Following microbial identification and antibiotic susceptibility tests, the isolates were subjected to WGS on the Illumina MiSeq platform. All the isolates showed genotypic resistance to tested β-lactams (NDM-1, OXA-1, CTX-M-15, TEM-1B, SHV-1) and other antibiotics. All but one isolate belonged to the ST152 with a novel sequence type, ST3136, differing by a single-locus variant. The isolates had the same plasmid multilocus sequence type (IncF[K12:A-:B36]) and capsular serotype (KL149), supporting the epidemiological linkage between the clones. Resistance to carbapenems in the 10 isolates was conferred by the blaNDM-1 mediated by the acquisition of multi-replicon [ColRNAI, IncFIB(pB171), Col440I, IncFII, IncFIB(K) and IncFII(Yp)] p18-43_01 plasmid. These findings suggest that the acquisition of blaNDM-1-bearing plasmid structure (p18-43_01), horizontal transfer and clonal dissemination facilitate the spread of carbapenemases in South Africa. This emphasizes the importance of targeted infection control measures to prevent dissemination.
Trace Element Distributions in the Zn-Pb (Mississippi Valley-Type) and Cu-Ag (Kupferschiefer) Sediment-Hosted Deposits in Poland
Authors: Mikulski Stanisław Z. , Oszczepalski Sławomir , Sadłowska Katarzyna , Chmielewski Andrzej , Małek Rafał
Published: January 2020

We applied geochemical (ICP-MS, WD-XRF, GFAAS, and AMA 254) and mineralogical (EPMA) studies of 137 samples to ore mineralization from Middle-Triassic sediment-hosted Zn-Pb (Mississippi Valley-type MVT) and Lower Zechstein sediment-hosted stratiform (SSC) Cu-Ag (Kupferschiefer-type) deposits in Poland. They contain a number of trace elements which are not recovered during the ore processing. Only Cu, Ag, Pb, Ni, Re, Se, Au, and PGE are extracted from Cu-Ag deposits while Zn and Pb are the only elements produced from Zn-Pb deposits. Zn-Pb deposits contain Cd, Ag, Ga, and Ba in slightly elevated concentrations and have potential to be mineral resources. This applies to a lesser extent to other trace elements (Bi, As, Hf, Tl, Sb, Se, and Re). However, only Cd and Ag show high enrichment factors indicative of potential for recovery. The bulk-rock analyses reveal strong correlations between Zn and Cd and Se, As and Mo, and weaker correlations between Ag and Cd, as well as Ga and Zn. Electron microprobe analyses of sphalerite revealed high concentrations of Cd (≤2.6 wt%) and Ag (≤3300 ppm). Zn-Pb deposits have fairly significant estimated resources of Ga and Sc (>1000 tons) and Cd (>10,000 tons). The Cu-Ag deposits have element signatures characterized by high values of Co, V, Ni, and Mo and much lower of Bi, As, Cd, Hg, Mo, Sb, and Tl. Bulk-rock analyses show strong correlations between Se and V; As and Co; Bi and Re; and weaker correlations between, for example, Cu and Mo; V, Ni, Ag and Mo; and Ni, V, and Co and Ni. The EPMA determinations reveal strong enrichments of Ag in Cu sulfides (geerite ≤ 10.1 wt %, chalcocite ≤ 6.28 wt %, bornite ≤ 3.29 wt %, djurleite ≤ 9080 ppm, yarrowite ≤ 6614 ppm, and digenite ≤ 3545 ppm). Silver minerals and alloys, as well as the native Ag and Au, were recorded in the Cu-Ag ores. Large resources of Co, V, and Ni (>100,000 tons) and Sc and Mo (>10,000 tons) are notable in Cu-Ag deposits. A number of trace elements, classified as critical for the economy of the European Union, including Ga and Ba (to a lesser extent Hf, Nb, and Sc) in Zn-Pb deposits, and Co and V in the Cu-Ag deposits, may eventually be recovered in the future from the studied deposits if proper ore-processing circuits and increasing demand are favorable.
Zircon U–Pb Geochronology, Whole-Rock Geochemistry and Petrogenesis of Biotite Granites in the Gaudeanmus Area, Namibia
Authors: Wang Shengyun , Fan Honghai , Chen Jinyong , Chen Donghuan
Published: January 2020

The Gaudeanmus area is located at the southern Central Zone of the Damara orogenic belt in south-western Africa. In this paper, we investigate the whole rock major and trace element compositions and Sr–Nd–Pb isotopic compositions of the biotite granite, and determine the age of the samples utilising U–Pb zircon dating methods. Our results provide an LA–collector inductively plasma mass spectrometer (ICP–MS) zircon U–Pb age for the biotite granite of 540 ± 4 Ma (i.e., earliest Cambrian). The biotite granites show the characteristics of metaluminous compositions belonging to high-K calc–alkaline to shoshonite series. The granites contain high alkali and rare earth elements (REE), are enriched in large-ion lithophile elements (Rb, K, Pb), and depleted in high field-strength elements (Nb, Ta, Ti). The REE patterns are characterised by enrichment of LREEs relative to HREEs and medium negative Eu anomalies in the chondrite-normalised REE diagram. These rocks have high initial 87Sr/86Sr ratios (0.71400–0.71768); low εNd(t) value (−12.0 to −7.1); Sm–Nd isotope crust model ages ranging from 1711 to 2235 Ma; and large variations in 206Pb/204Pb (18.0851–19.2757), 207Pb/204Pb (15.6258–15.7269), and 208Pb/204Pb ratios (38.7437–40.5607). Such geochemical signatures indicate that the biotite granite rocks derive mainly from partial melting of ancient crustal rocks resembling the local basement meta-sedimentary rocks. However, minor mantle-derived materials may have also been involved in the formation of these rocks. Combining with regional tectonic evolution, we consider that the biotite granite intrusions in the Gaudeanmus area formed in a transitional tectonic regime that went from compressional to extensional tectonics.
Effect of Graphite on Copper Bioleaching from Waste Printed Circuit Boards
Authors: Tong Linlin , Zhao Qianfei , Kamali Ali , Sand Wolfgang , Yang Hongying
Published: January 2020

The efficient extraction of copper as a valuable metal from waste printed circuit boards (WPCBs) is currently attracting growing interest. Here, we systematically investigated the impact of bacteria on the efficiency of copper leaching from WPCBs, and evaluated the effect of graphite on bioleaching performance. The HQ0211 bacteria culture containing Acidithiobacillus ferrooxidans, Ferroplasma acidiphilum, and Leptospirillum ferriphilum enhanced Cu-leaching performance in either ferric sulfate and sulfuric acid leaching, so a final leaching of up to 76.2% was recorded after 5 days. With the addition of graphite, the percentage of copper leaching could be increased to 80.5%. Single-factor experiments confirmed the compatibility of graphite with the HQ0211 culture, and identified the optimal pulp density of WPCBs, the initial pH, and the graphite content to be 2% (w/v), 1.6, and 2.5 g/L, respectively.
The In-Situ Quantification of Structural Radiation Damage in Zircon Using Laser-Induced Confocal Photoluminescence Spectroscopy
Authors: Lenz Christoph , Belousova Elena , Lumpkin Gregory R.
Published: January 2020

We present a new methodology for laser-induced steady-state photoluminescence (PL) spectroscopy of Dy3+ that aims at a direct quantification of the amorphous fraction fa present in zircon (ZrSiO4), which undergoes a transition from a crystalline to a metamict state due to cumulative self-irradiation damage caused by the radioactive decay of substituted U and Th. Using state-of-the-art confocal spectrometers attached to optical microscopes, measurements may be performed non-destructively on the micrometre length-scale with the option to visualize radiation-damage patterns as revealed by hyperspectral PL maps. Zircon from the Ratnapura district (Sri Lanka, ~520 Ma), was used as reference material to substantiate the applicability of the proposed method. The accumulation of radiation damage in this material was investigated in detail and obtained fa values correlate with calculated α-doses in accordance to the direct impact model reported variously in the literature. The impact of chemically-induced, heterogeneous broadening of Raman and Dy3+ emission spectral bands is discussed on two examples from Mt. Malosa district, Malawi. A mean weighted U-Pb isotope age of 111 ± 1 Ma (pegmatitic-type) and a discordia age of 112 ± 1.6 Ma (hydrothermal-type) as obtained by LA-ICP-MS confirm their close genetic and temporal relationship. Studied zircon examples demonstrate that the amount of radiation damage present may have a substantial effect on the precision of LA-ICP-MS ages, but cannot be considered an exclusive cause for bias of obtained isotope ages.
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K
Authors: Liu Yannan , Fan Daidi
Published: January 2020

Ginsenosides have been reported to possess various pharmacological effects, including anticancer effects. Nevertheless, there are few reports about the antitumor activity and mechanisms of ginsenoside Rg5 against breast cancer cells. In the present study, the major ginsenoside Rb1 was transformed into the rare ginsenoside Rg5 through enzymatic bioconversion and successive acid-assisted high temperature and pressure processing. Ginsenosides Rb1, Rg3, and Rg5 were investigated for their antitumor effects against five human cancer cell lines via the MTT assay. Among them, Rg5 exhibited the greatest cytotoxicity against breast cancer. Moreover, Rg5 remarkably suppressed breast cancer cell proliferation through mitochondria-mediated apoptosis and autophagic cell death. LC3B-GFP/Lysotracker and mRFP-EGFP-LC3B were utilized to show that Rg5 induced autophagosome-lysosome fusion. Western blot assays further illustrated that Rg5 decreased the phosphorylation levels of PI3K, Akt, mTOR, and Bad and suppressed the PI3K/Akt signaling pathway in breast cancer. Moreover, Rg5-induced apoptosis and autophagy could be dramatically strengthened by the PI3K/Akt inhibitor LY294002. Finally, a molecular docking study demonstrated that Rg5 could bind to the active pocket of PI3K. Collectively, our results revealed that Rg5 could be a potential therapeutic agent for breast cancer treatment.
Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function
Authors: Kim Sung Ho , Seong Geum Su , Choung Se Young
Published: January 2020

Morinda citrifolia, a fruit generally known as “Noni”, has been traditionally used in parts of East Asia to relieve inflammatory diseases. Although several studies using noni have been reported, the effect of fermented Morinda citrifolia (F.NONI) on atopic dermatitis (AD) has not been investigated. Thus, we aimed to investigate the improving effect of F.NONI treatment on AD-like skin lesions and elucidate molecular mechanisms. F.NONI was prepared by the fermentation of noni fruit with probiotics and then extracted. F.NONI was orally administrated to NC/Nga mice to evaluate its therapeutic effect on 2,4-dinitrochlorobenzene (DNCB)-induced AD. Oral administration of F.NONI significantly alleviated AD lesions and symptoms such as dermatitis scores, ear thickness, scratching behavior, epidermal thickness, and infiltration of inflammatory cells (e.g., mast cells and eosinophils). In addition, F.NONI treatment reduced the levels of histamine, IgE and IgG1/IgG2a ratio, thymus and activation regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP) in serum and beneficially modulated the expressions of Th1, Th2, Th17, and Th22-mediated cytokines in lesioned skin and splenocytes. Furthermore, the expressions of the skin barrier-related proteins including filaggrin (FLG), loricrin (LOR), involucrin (IVL), zonula occludens-1 (ZO-1), and occludin (OCC) were restored by F.NONI treatment. Taken together, these results suggest that F.NONI could be a therapeutic agent to attenuate AD-like skin lesions through modulating the immune balance and skin barrier function.
Dietary Daily Sodium Intake Lower than 1500 mg Is Associated with Inadequately Low Intake of Calorie, Protein, Iron, Zinc and Vitamin B1 in Patients on Chronic Hemodialysis
Authors: Bossola Maurizio , Di Stasio Enrico , Viola Antonella , Cenerelli Stefano , Leo Alessandra , Santarelli Stefano , Monteburini Tania
Published: January 2020

Background: To measure daily sodium intake in patients on chronic hemodialysis and to compare the intake of nutrients, minerals, trace elements, and vitamins in patients who had a daily sodium intake below or above the value of 1500 mg recommended by the American Heart Association. Methods: Dietary intake was recorded for 3 days by means of 3-day diet diaries in prevalent patients on chronic hemodialysis. Each patient was instructed by a dietitian on how to fill the diary, which was subsequently signed by a next of kin. Results: We studied 127 patients. Mean sodium intake (mg) was 1295.9 ± 812.3. Eighty-seven (68.5%) patients had a daily sodium intake <1500 mg (group 1) and 40 (31.5%) ≥ 1500 mg (group 2). Correlation between daily sodium intake and daily calorie intake was significant (r = 0.474 [0.327 to 0.599]; p < 0.0001). Daily calorie intake (kcal/kg/day) was lower in group 1 (21.1 ± 6.6; p = 0.0001) than in group 2 (27.1 ± 10.4). Correlation between daily sodium intake and daily protein intake was significant (r = 0.530 [0.392 to 0.644]; p < 0.0001). The daily protein intake (grams/kg/day) was lower in group 1 (0.823 ± 0.275; p = 0.0003) than in group 2 (1.061 ± 0.419). Daily intake of magnesium, copper, iron, zinc, and selenium was significantly lower in group 1 than in group 2. Daily intake of vitamin A, B2, B3, and C did not differ significantly between group 1 and group 2. Daily intake of vitamin B1 was significantly lower in group 1 than in group 2. Significantly lower was, in group 1 than in group 2, the percentage of patients within the target value with regard to intake of calories (11.5% vs. 37.5%; p = 0.001) and proteins (9.2% vs. 27.5%; p = 0.015) as well as of iron (23% vs. 45%; p = 0.020), zinc (13.8% vs. 53.8%; p = 0.008) and vitamin B1 (8.1% vs. 50%; p < 0.001). Conclusion: A low daily intake of sodium is associated with an inadequately low intake of calorie, proteins, minerals, trace elements, and vitamin B1. Nutritional counselling aimed to reduce the intake of sodium in patients on chronic hemodialysis should not disregard an adequate intake of macro- and micronutrients, otherwise the risk of malnutrition is high.
Regulation of Skeletal Muscle Function by Amino Acids
Authors: Kamei Yasutomi , Hatazawa Yukino , Uchitomi Ran , Yoshimura Ryoji , Miura Shinji
Published: January 2020

Amino acids are components of proteins that also exist free-form in the body; their functions can be divided into (1) nutritional, (2) sensory, and (3) biological regulatory roles. The skeletal muscle, which is the largest organ in the human body, representing ~40% of the total body weight, plays important roles in exercise, energy expenditure, and glucose/amino acid usage—processes that are modulated by various amino acids and their metabolites. In this review, we address the metabolism and function of amino acids in the skeletal muscle. The expression of PGC1α, a transcriptional coactivator, is increased in the skeletal muscle during exercise. PGC1α activates branched-chain amino acid (BCAA) metabolism and is used for energy in the tricarboxylic acid (TCA) cycle. Leucine, a BCAA, and its metabolite, β-hydroxy-β-methylbutyrate (HMB), both activate mammalian target of rapamycin complex 1 (mTORC1) and increase protein synthesis, but the mechanisms of activation appear to be different. The metabolite of valine (another BCAA), β-aminoisobutyric acid (BAIBA), is increased by exercise, is secreted by the skeletal muscle, and acts on other tissues, such as white adipose tissue, to increase energy expenditure. In addition, several amino acid-related molecules reportedly activate skeletal muscle function. Oral 5-aminolevulinic acid (ALA) supplementation can protect against mild hyperglycemia and help prevent type 2 diabetes. β-alanine levels are decreased in the skeletal muscles of aged mice. β-alanine supplementation increased the physical performance and improved the executive function induced by endurance exercise in middle-aged individuals. Further studies focusing on the effects of amino acids and their metabolites on skeletal muscle function will provide data essential for the production of food supplements for older adults, athletes, and individuals with metabolic diseases.
Probing Vacuum Polarization Effects with High-Intensity Lasers
Authors: Karbstein Felix
Published: January 2020

These notes provide a pedagogical introduction to the theoretical study of vacuum polarization effects in strong electromagnetic fields as provided by state-of-the-art high-intensity lasers. Quantum vacuum fluctuations give rise to effective couplings between electromagnetic fields, thereby supplementing Maxwell’s linear theory of classical electrodynamics with nonlinearities. Resorting to a simplified laser pulse model, allowing for explicit analytical insights, we demonstrate how to efficiently analyze all-optical signatures of these effective interactions in high-intensity laser experiments. Moreover, we highlight several key features relevant for the accurate planning and quantitative theoretical analysis of quantum vacuum nonlinearities in the collision of high-intensity laser pulses.
Tuning of Fiber Optic Surface Reflectivity through Graphene Oxide-Based Layer-by-Layer Film Coatings
Authors: Monteiro Catarina S. , Raposo Maria , Ribeiro Paulo A. , Silva Susana O. , Frazão Orlando
Published: January 2020

The use of graphene oxide-based coatings on optical fibers are investigated, aiming to tune the reflectivity of optical fiber surfaces for use in precision sensing devices. Graphene oxide (GO) layers are successfully deposited onto optical fiber ends, either in cleaved or hollow microspheres, by mounting combined bilayers of polyethylenimine (PEI) and GO layers using the Layer-by-Layer (LbL) technique. The reflectivity of optical fibers coated with graphene oxide layers is investigated for the telecom region allowing to both monitor layer growth kinetics and cavity characterization. Tunable reflective surfaces are successfully attained in both cleaved optical fibers and hollow microsphere fiber-based sensors by simply coating them with PEI/GO layers through the LbL film technique.
Development of an Interference Filter-Stabilized External-Cavity Diode Laser for Space Applications
Authors: Zhang Linbo , Liu Tao , Chen Long , Xu Guanjun , Jiang Chenhui , Liu Jun , Zhang Shougang
Published: January 2020

The National Time Service Center of China is developing a compact, highly stable, 698 nm external-cavity diode laser (ECDL) for dedicated use in a space strontium optical clock. This article presents the optical design, structural design, and preliminary performance of this ECDL. The ECDL uses a narrow-bandwidth interference filter for spectral selection and a cat’s-eye reflector for light feedback. To ensure long-term stable laser operation suitable for space applications, the connections among all the components are rigid and the design avoids any spring-loaded adjustment. The frequency of the first lateral rocking eigenmode is 2316 Hz. The ECDL operates near 698.45 nm, and it has a current-controlled tuning range over 40 GHz and a PZT-controlled tuning range of 3 GHz. The linewidth measured by the heterodyne beating between the ECDL and an ultra-stable laser with 1 Hz linewidth is about 180 kHz. At present, the ECDL has been applied to the principle prototype of the space ultra-stable laser system.
QED Response of the Vacuum
Authors: Leuchs Gerd , Hawton Margaret , Sánchez-Soto Luis L.
Published: January 2020

We present a new perspective on the link between quantum electrodynamics (QED) and Maxwell’s equations. We demonstrate that the interpretation of the electric displacement vector D = ε 0 E , where E is the electric field vector and ε 0 is the permittivity of the vacuum, as vacuum polarization is consistent with QED. A free electromagnetic field polarizes the vacuum, but the polarization and magnetization currents cancel giving zero source current. The speed of light is a universal constant, while the fine structure constant, which couples the electromagnetic field to matter runs, as it should.
Centrality of Religiosity, Attitude towards Christianity and Post-Critical Belief: Comparing Three Measures of Religiosity
Authors: Riegel Ulrich
Published: January 2020

The Centrality of Religiosity Scale (CRS), the Francis Scale of Attitude towards Christianity (FAC) and the Post-Critical Belief Scale (PCB) are three prominent measures of religiosity. Comparing the three measures on theoretical grounds, one may assume that high religiosity (CRS) is linked to both a strong attitude towards Christianity (FAC) and to orthodoxy (PCB), while no religiosity (CRS) may be associated with both a low expressed attitude towards Christianity (FAC) and external critique (PCB). This paper examines that assumption on the basis of a convenience sample of N = 4.396 participants that filled in an online questionnaire (age: M = 47; SD = 15.90; 47% females; denomination: 1226 Roman-Catholics, 2369 Protestants, and 801 participants that have left the Roman Catholic or Protestant church). Factor analysis supports the one-dimensional structure of CRS and FAC. Exploratory factor analysis reconstructs the two-dimensional structure of PCB. There is a very high positive correlation between CRS and FAC (r = 0.92), indicating that CRS and FAC measure the same issue within a Christian context. Moreover, CRS and external critique of PCB correlate heavily negatively (r = −0.83). Finally, there is a very moderate negative correlation between CRS and relativism (r = −0.26). Multiple regression analysis reveals that both factors predict much of CRS (R2 = 0.75) or FAC (R2 = 0.83), while age and gender are of minor impact. Region, education, and income do not predict the outcome of CRS or FAC at all. This result will be discussed.
Acknowledgement to Reviewers of Religions in 2019
Authors:   Religions Editorial Office
Published: January 2020

The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not [...]
Ground Based Hyperspectral Imaging to Characterize Canopy-Level Photosynthetic Activities
Authors: Jiang Yu , Snider John L. , Li Changying , Rains Glen C. , Paterson Andrew H.
Published: January 2020

Improving plant photosynthesis provides the best possibility for increasing crop yield potential, which is considered a crucial effort for global food security. Chlorophyll fluorescence is an important indicator for the study of plant photosynthesis. Previous studies have intensively examined the use of spectrometer, airborne, and spaceborne spectral data to retrieve solar induced fluorescence (SIF) for estimating gross primary productivity and carbon fixation. None of the methods, however, had a spatial resolution and a scanning throughput suitable for applications at the canopy and sub-canopy levels, thereby limiting photosynthesis analysis for breeding programs and genetics/genomics studies. The goal of this study was to develop a hyperspectral imaging approach to characterize plant photosynthesis at the canopy level. An experimental field was planted with two cotton cultivars that received two different treatments (control and herbicide treated), with each cultivar-treatment combination having eight replicate 10 m plots. A ground mobile sensing system (GPhenoVision) was configured with a hyperspectral module consisting of a spectrometer and a hyperspectral camera that covered the spectral range from 400 to 1000 nm with a spectral sampling resolution of 2 nm. The system acquired downwelling irradiance spectra from the spectrometer and reflected radiance spectral images from the hyperspectral camera. On the day after 24 h of the DCMU (3-(3,4-dichlorophenyl)-1,1-dimethylurea) application, the system was used to conduct six data collection trials in the experiment field from 08:00 to 18:00 with an interval of two hours. A data processing pipeline was developed to measure SIF using the irradiance and radiance spectral data. Diurnal SIF measurements were used to estimate the effective quantum yield and electron transport rate, deriving rapid light curves (RLCs) to characterize photosynthetic efficiency at the group and plot levels. Experimental results showed that the effective quantum yields estimated by the developed method highly correlated with those measured by a pulse amplitude modulation (PAM) fluorometer. In addition, RLC characteristics calculated using the developed method showed similar statistical trends with those derived using the PAM data. Both the RLC and PAM data agreed with destructive growth analyses. This suggests that the developed method can be used as an effective tool for future breeding programs and genetics/genomics studies to characterize plant photosynthesis at the canopy level.
Performance Comparison of Geoid Refinement between XGM2016 and EGM2008 Based on the KTH and RCR Methods: Jilin Province, China
Authors: Wu Qiong , Wang Hongyao , Wang Bin , Chen Shengbo , Li Hongqing
Published: January 2020

The selection of an appropriate global gravity field model and refinement method can effectively improve the accuracy of the refined regional geoid model in a certain research area. We analyzed the accuracy of Experimental Geopotential Model (XGM2016) based on the GPS-leveling data and the modification parameters of the global mean square errors in the KTH geoid refinement in Jilin Province, China. The regional geoid was refined based on Earth Gravitational Model (EGM2008) and XGM2016 using both the Helmert condensation method with an RCR procedure and the KTH method. A comparison of the original two gravity field models to the GPS-leveling benchmarks showed that the accuracies of XGM2016 and EGM2008 in the plain area of Jilin Province are similar with a standard deviation (STD) of 5.8 cm, whereas the accuracy of EGM2008 in the high mountainous area is 1.4 cm better than that of XGM2016, which may be attributed to its low resolution. The modification parameters between the two gravity field models showed that the coefficient error of XGM2016 model was lower than that of EGM2008 for the same degree of expansion. The different modification limits and integral radii may produce a centimeter level difference in global mean square error, while the influence of the truncation error caused by the integral was at the millimeter level. The terrestrial gravity data error accounted for the majority of the global mean square error. The optimal least squares modification obtained the minimum global mean square error, and the global mean square error calculated based on XGM2016 model was reduced by about 1~3 cm compared with EGM2008. The refined geoid based on the two gravity field models indicated that both KTH and RCR method can effectively improve the STD of the geoid model from about six to three centimeters. The refined accuracy of EGM2008 model using RCR and KTH methods is slightly better than that of XGM2016 model in the plain and high mountain areas after seven-parameter fitting. EGM2008 based on the KTH method was the most precise at ± 2.0 cm in the plain area and ± 2.4 cm in the mountainous area. Generally, for the refined geoid based on the two Earth gravity models, KTH produced results similar to RCR in the plain area, and had relatively better performance for the mountainous area where terrestrial gravity data is sparse and unevenly distributed.
Online Semantic Subspace Learning with Siamese Network for UAV Tracking
Authors: Zha Yufei , Wu Min , Qiu Zhuling , Sun Jingxian , Zhang Peng , Huang Wei
Published: January 2020

In urban environment monitoring, visual tracking on unmanned aerial vehicles (UAVs) can produce more applications owing to the inherent advantages, but it also brings new challenges for existing visual tracking approaches (such as complex background clutters, rotation, fast motion, small objects, and realtime issues due to camera motion and viewpoint changes). Based on the Siamese network, tracking can be conducted efficiently in recent UAV datasets. Unfortunately, the learned convolutional neural network (CNN) features are not discriminative when identifying the target from the background/clutter, In particular for the distractor, and cannot capture the appearance variations temporally. Additionally, occlusion and disappearance are also reasons for tracking failure. In this paper, a semantic subspace module is designed to be integrated into the Siamese network tracker to encode the local fine-grained details of the target for UAV tracking. More specifically, the target’s semantic subspace is learned online to adapt to the target in the temporal domain. Additionally, the pixel-wise response of the semantic subspace can be used to detect occlusion and disappearance of the target, and this enables reasonable updating to relieve model drifting. Substantial experiments conducted on challenging UAV benchmarks illustrate that the proposed method can obtain competitive results in both accuracy and efficiency when they are applied to UAV videos.
Evaluation of E Layer Dominated Ionosphere Events Using COSMIC/FORMOSAT-3 and CHAMP Ionospheric Radio Occultation Data
Authors: Kamal Sumon , Jakowski Norbert , Hoque Mohammed M. , Wickert Jens
Published: January 2020

At certain geographic locations, especially in the polar regions, the ionization of the ionospheric E layer can dominate over that of the F2 layer. The associated electron density profiles show their ionization maximum at E layer heights between 80 and 150 km above the Earth’s surface. This phenomenon is called the “E layer dominated ionosphere” (ELDI). In this paper we systematically investigate the characteristics of ELDI occurrences at high latitudes, focusing on their spatial and temporal variations. In our study, we use ionospheric GPS radio occultation data obtained from the COSMIC/FORMOSAT-3 (Constellation Observing System for Meteorology, Ionosphere, and Climate/Formosa Satellite Mission 3) and CHAMP (Challenging Minisatellite Payload) satellite missions. The entire dataset comprises the long period from 2001 to 2018, covering the previous and present solar cycles. This allows us to study the variation of the ELDI in different ways. In addition to the geospatial distribution, we also examine the temporal variation of ELDI events, focusing on the diurnal, the seasonal, and the solar cycle dependent variation. Furthermore, we investigate the spatiotemporal dependency of the ELDI on geomagnetic storms.
Use of a Novel Resistive Strain Sensor Approach in an Experimental and Theoretical Study Concerning Large Spherical Storage Tank Structure Behavior During Its Operational Life and Pressure Tests
Authors: Florescu Virgil , Mocanu Stefan , Rece Laurentiu , Ursache Robert , Goga Nicolae , Marian Constantin Viorel
Published: January 2020

This paper introduces a new method for the use of tensor-resistive sensors in large spherical storage tank equipment (over 12,000-mm diameters). We did an experiment with 19 petroleum or ammonia product sphere-shaped storage tanks with volumes of 1000 and 1800 cubic meters, respectively. The existing literature only contains experiments based on sensors for tanks with diameters no larger than 600 mm. Based on a number of resistive strain sensor measurements on large spherical pressurized vessels regarding structural integrity assessment, the present paper is focused on the comparison between "real-life" obtained sensor data versus finite element method (FEM) simulation results. The present paper is structured in three parts and examines innovative directions: the use of the classic tensor-resistive sensors in a new approach concerning large structural equipment; an original 3D modeling method with the help of the FEM; and conclusions with possible implications on the regulations, design, or maintenance as a result of the attempt of mutual validation of the new methods previously mentioned.
Vision-Based Localization System Suited to Resident Underwater Vehicles
Authors: Trslić Petar , Weir Anthony , Riordan James , Omerdic Edin , Toal Daniel , Dooly Gerard
Published: January 2020

In recent years, we have seen significant interest in the use of permanently deployed resident robotic vehicles for commercial inspection, maintenance and repair (IMR) activities. This paper presents a concept and demonstration, through offshore trials, of a low-cost, low-maintenance, navigational marker that can eliminate drift in vehicle INS solution when the vehicle is close to the IMR target. The subsea localisation marker system is fixed on location on the resident field asset and is used in on-vehicle machine vision algorithms for pose estimation and facilitation of a high-resolution world coordinate frame registration with a high refresh rate. This paper presents evaluation of the system during trials in the North Atlantic Ocean during January 2019. System performances and propagation of position error is inspected and estimated, and the effect of intermittent visual based position update to Kalman filter and onboard INS solution is discussed. The paper presents experimental results of the commercial state-of-the-art inertial navigation system operating in the pure inertial mode for comparison.