bluuebunny/crossref_metadata_2025 huggingface dataset:
The Memory of the Crusades in the Ideology and Propaganda of Radical Islam
Authors: С.В. Демиденко, , А.А. Кутузова,
Published: December 2022

Статья посвящена вопросам идеологии радикального ислама и места в ней крестовых походов. С опорой на корпус научной литературы, посвященной проблеме исторической памяти и истории исламского радикализма, и источники (священные тексты исламской религии, фетвы радикальных имамов, данные отечественной и зарубежной прессы и т.д.) изучены основы идейной концепции радикального ислама, дана оценка данного феномена в контексте возрастания вооруженной активности радикалов в Европе и США. Особое внимание в исследовании уделяется проблеме священной войны и репрезентации крестовых походов через призму этой концепции. Очевидно, что сегодня «воспоминания» о событиях Средневековья заняли в идеологии и пропаганде радикального ислама особое место.

The article is devoted to the ideology of radical Islam and the place of the Crusades in it. Based on the corpus of scientific literature devoted to the problem of historical memory and history of radical Islam, and sources (sacred texts of the Islamic religion, fatwas of radical imams, data from the domestic and foreign press, etc.) the basics of the ideological concept of radical Islam have been studied, an assessment of this phenomenon is given in the context of an increase in armed activity radicals in Europe and the USA. Special attention in the study is paid to the concept of holy war and its representation through the prism of this concept of the Crusades. It is obvious that today the "memories" of the events of the Middle Ages have taken a special place in ideology and propaganda of radical Islam.
Film Battle for Traumatic Memory: “Dara from Yasenovac” (2020) under the Fire of Criticism
Authors: М.В. Белов,
Published: December 2022

Сербский фильм «Дара из Ясеноваца» (2020), посвященный теме выживания детей в фашистском концлагере, вызвал бурную полемику на разных уровнях задолго до того, как стал доступен широкой аудитории зрителей. Противники фильма, упрощая ситуацию, посчитали его исключительным продуктом государственной пропаганды. Вместе с тем предпоказная конфронтация вокруг ожидаемой киноработы послужила хорошей рекламной кампанией, вопреки желанию, поддержанной суровыми критиками фильма. Это идеальный пример того, как тесно в информационную эпоху сбли-жаются, переплетаясь между собой и притворяясь друг другом, политика и эстетика. история (как стремление к истине) и кинобизнес, образование и «диванный» патриотизм. Точно так же смешались до неузнаваемости вроде бы полярные векторы – стремление к международному признанию и национальной обособленности.

The Serbian film «Dara from Jasenovac» (2020), dedicated to the topic of child survival in a Nazi concentration camp, caused a heated discussion long before it became available to a broad audience. The opponents of the movie considered it to be an exceptional product of state-sponsored propaganda. At the same time, the pre-release confrontation turned out to be a good advertising campaign supported by the harsh critics against their wishes. This is a perfect example of how politics and aesthetics closely converge, intertwine and pretend to be each other in the information age: history (as the pursuit of truth) and the film industry, education and “passive” patriotism. Similarly, the desire for international recognition and national separateness, which are seemingly polar vectors, also mix beyond recognition.
The Armenian Church Between the Persian and Eastern Roman Empires: The Formation of the Armenian Autocephalous Church
Authors: Л. Маргарян,
Published: December 2022

В статье рассматриваются некоторые аспекты ранней истории армянского христианства. Находясь между Сасанидской державой и Восточной Римской империей, Армения, для сохранения своей политической и культурной независимости, стремилась достичь баланса во взаимоотношениях с этими двумя могущественными державами региона. Однако усилия армянской политической элиты не всегда приводили к желаемому результату, что неотвратимо вело Армению к потере государственности. В этой ситуации основным и весьма эффективным инструментом для сохранения идентичности и формирования средневековой нации стало христианство. В статье рассматривается политика Армянской церкви по отношению к Сасанидам, так и к Империи Ромеев. Именно эта политика стала определяющей в армяно-иранских и армяно-византийских отношениях, она предопределила дальнейшие этапы формирования Армянской апостольской церкви.

The article deals with some aspects of the early history of Armenian Christianity. Being situated between the Sasanian state and the Eastern Roman Empire, Armenia sought to strike a balance in relations with these regional powers in order to maintain its political and cultural independence. However, the Armenian political elite ultimately failed in this endeavour, leading to Armenia’s loss of statehood. In this situation Christianity became the primary and very effective tool for preserving Armenian identity and forming a medieval nation. The article discusses the policy of the Armenian Church towards the Sasanians and the Roman Empire. This policy was decisive in Armenian–Iranian and Armenian–Byzantine relations, and influenced further stages in the formation of the Armenian Apostolic Church.
Dialogue of Cultures of West and East in the Views of V.I. Lamansky, A St. Petersburg Thinker at the Turn of the 19th-20th Centuries
Authors: Е.Е. Михайлова,
Published: December 2022

В статье рассматривается тема диалога культур Запада и Востока, специфически раскрытая в трудах В.И. Ламанского. Изложение выдержано в формате обсуждения книги В.А. Куприянова и А.В. Малинова «Академик В.И. Ламанский. Материалы к биографии и научной деятельности» (2020), в которой осуществлена перекрестная референция научных и политических взглядов историка. Автор считает, что ряд суждений Ламанского звучит современно. Диалог есть важный инструмент взаимодействия культур; гуманистический фактор лежит в основе диалога и выражен триадой «язык-культура-самосознание»; Россия способна быть центром притяжения разнородных культур – эти и другие идеи Ламанского могут вызвать интерес специалистов и рефлексирующих читателей.

The article examines the dialogue between the West culture and the East culture, specifically disclosed in the works of the St. Petersburg thinker at the turn of the 19TH-20TH centuries V.I. Lamansky. In this regard, the presentation of the article is in the format of a discussion of the book by V.A. Kupriyanov and A.V. Malinov “Academician V.I. Lamansky. Materials for biography and scientific activity "(2020), in which a cross-reference of the historian's scientific and political views is carried out. The author believes that a number of Lamansky's judgments sound modern. Dialogue is an important tool for the interaction of cultures; the humanistic factor underlies the dialogue and is expressed by the triad "language-culture-self-awareness"; Russia is capable of being a center of attraction for heterogeneous cultures - these and other ideas of Lamansky can arouse the interest of specialists and reflective readers.
Rationality and Non-Rationality Testing to Different Form of Whistleblowing
Authors: Yustina Andi Ina , Sugiyanto Phyrel Asri , Dewi Christine Novita , Mahmudah Hadi
Published: December 2022

Whistleblowing is an incredibly effective method of preventing and identifying fraud. Indeed, a variety of circumstances contribute to an employee’s choice to file a whistle-blower complaint. The goal of this research is to illustrate the effect of perceived danger severity and perceived wrongdoing severity on whistleblowing intention using emotion as a moderator. This research used a quantitative approach. The major source of data was questionnaires issued to workers at a variety of businesses. A total of 207 samples were taken. In our investigation, we used SEM-PLS. Threat perception has an impact on negative mood and has a detrimental effect on whistleblowing intention, according to the research. Whereas the perceived gravity of misbehaviour improves one’s mood and raises the possibility of whistleblowing.
The Attachment of Leadership and Followership that Prioritizes Integrity in Realizing an Anti-Corruption Organization
Authors: Dewi Iftitah Rizky , Syakir Muhamad Fuad Budi
Published: December 2022

Humans play an important role in an organization. Humans, according to their responsibilities in an organization, are divided into leaders and followers. Both leaders and followers create a dynamic environment that produces organizational culture. This paper aims to emphasize the imperative need for leaders and followers to act with integrity. Tone at the top has proven to be an effective antidote to corruption, while followers must also be able to protect their leaders from asymmetric information that could lead them to unfair decisions. The method used in this paper is a literature study and comparative analysis applied in private companies in South Tangerang and public offices in Jakarta. The results of this study demonstrate the importance of integrity for both leaders and followers in achieving an anti-corruption organization.
KURUÇAY KAZASINDA XVIII. YÜZYIL ORTALARINDA MEYDANA GELEN ASAYİŞ SORUNLARI VE DEVLET MERKEZİNİN YAKLAŞIMI (1 VE 3 NUMARALI ERZURUM AHKÂM DEFTERLERİNE GÖRE)
Authors: DURMUŞ Gürsel
Published: December 2022

Osmanlı İmparatorluğu’nda ahalinin her türlü davasına “şer’iyye mahkemeleri” adı verilen kadı mahkemeleri bakardı. Fakat bölgesel nitelikli bu mahkemelerin kararlarından memnun kalmayanların, en yüksek yönetim ve yargı organı mahiyetindeki Divanıhümayun’a müracaat etme hakları vardı. Bundan başka, herhangi bir şer’iyye mahkemesine başvurmadan doğrudan Divanıhümayun’a da gidilebilmekteydi. Buraya akseden davalar başlangıçta “mühimme defterleri” içerisinde yer alırken, sonra “şikâyet defterleri” denilen defterlere ve H 1155 / M 1742’den itibaren de “ahkâm defterleri” adı verilen ayrı bir defter serisine kaydedilmeye başlanmışlardır. Ahkâm defterleri, özellikle “şer’iyye sicilleri” adı verilen kadı mahkemeleri kayıtlarının bulunmadığı bölgelerin şehir tarihi incelemeleri bakımından ehemmiyetlidirler. Şer’iyye sicilleri mevcut olan bölgelerde ise olaylara devlet merkezinin bakış açısını yansıtmaları nedeniyle önem taşırlar. Bu çalışmada, ilgili dönemde Erzurum eyaletine bağlı olan Kuruçay kazasının XVIII. yüzyıl ortalarındaki asayiş durumu 1 ve 3 numaralı Erzurum Ahkâm Defterleri üzerinden incelenmiştir. Ayrıca, devlet merkezinin bölgeden yansıyan şikâyetlere yaklaşımı ve Divan’dan yazılan hükümlerde sunulan çözüm önerileri ortaya konulmaya çalışılıp sorunların nedenleri de irdelenmiştir.
Innovative approach applications for groundwater management at the Ajmer division
Authors: Phulpagar Sanju Ramesh , Kale Ganesh D.
Published: December 2022

For proper management of groundwater (GW) resources, appropriate management strategies are necessary. It is essential to know where and why these management strategies need to be applied. For this prioritization of GW blocks and identification of factors affecting declining trends in GW are essential and for addressing these issues, two innovative approaches are applied in the present study. In the first approach, prioritization of GW blocks is performed by employing trend analysis in seasonal groundwater levels (GWLs) while identification of factors affecting declining trends in GW is performed in second approach by analyzing trends in climatic parameters, namely MNTEMP and rainfall (RF). Stage of GW development in most of the blocks in districts of the Ajmer division has already exceeded 100%, which indicated that the scope of GW development is already exhausted. Thus, in the present study, aforesaid approaches are applied at every block in districts of the Ajmer division for proper management of GW resources. Results showed that, in some blocks, GW is found to be significantly declining due to significantly incrementing MNTEMP and declining RF. Also, GW is found to be declining due to declining RF at few blocks and due to significantly incrementing MNTEMP at some blocks in districts of the Ajmer division.
"Gay Friendly pra quem"?
Authors: Gularte Moreira Maicon , Censon Dianine , Jung de Campos Luciene
Published: December 2022

O turismo tem defendido a segmentação LGBT não apenas como alternativa econômica, mas também de inclusão. A existência de contradições que evidenciam a subversão dessa ética nos levou ao documentário “Depois do Fervo” (Faisting, 2017), que problematiza a cidade de Florianópolis/SC - Brasil como um destino turístico gay friendly. Pela análise de seus efeitos de sentido, orientados pela Análise do Discurso de Michel Pêcheux, questionamos se seria possível problematizar relações entre reprodução ideológica e produção de violência no/pelo turismo. A partir de nossas análises, consideramos contingente repensar as práticas de turismo LGBT, buscando romper com as estruturas de reprodução ideológicas dominantes e de produção de violência contra a população LGBT. Também, que políticas públicas voltadas ao turismo LGBT devem ser pensadas com a consideração das demais políticas necessárias à garantia dos direitos LGBT. Por fim, propomos a construção de uma agenda de políticas públicas em que esses processos sejam mutuamente considerados entre si.
Turismo religioso e os impactos do COVID-19 no setor de bares e restaurantes de São José de Ribamar - MA
Authors: Soares Maria , Rodrigues de Sousa Lucyane , Guedes Cutrim Kláutenys Dellene
Published: December 2022

RESUMO

O turismo religioso é um segmento crescente ligado ao calendário de eventos do país, um fenômeno social que por meio dos deslocamentos a festas e espaços religiosos, reúne multidões, adeptos que se utilizam do tripé turístico: transporte, hospedagem e alimentação, proporcionando desenvolvimento econômico as localidades com a geração de emprego e renda. No entanto, a pandemia do COVID-19, a mais severa crise sanitária dos últimos tempos e a necessidade de medidas como isolamento social para conter a disseminação do vírus causaram um profundo impacto a economia mundial, sendo o turismo o setor mais impactado. Nesse sentido, este artigo que é parte final da pesquisa realizada durante a pandemia em São José de Ribamar, cidade conhecida pela cultura religiosa, tem como objetivo apresentar um estudo acerca dos impactos da pandemia no setor de bares e restaurantes. Para tanto, fez-se pesquisa bibliográfica e de campo onde utilizou-se instrumento de questionário sendo aplicado junto aos donos dos empreendimentos que fazem parte do setor turístico que mais fechou postos de trabalho no Brasil, de acordo com o Relatório de Impacto do Ministério do Turismo (2020). A pesquisa foi realizada na cidade em setembro de 2021, durante o festejo de São José de Ribamar, o qual teve parte realizado virtualmente, sem romarias nem procissões. Para os resultados, aponta-se a ausência em maior parte dos empreendimentos, em relação ao uso de mídias digitais para divulgação de produtos e serviços, descontentamento com medidas governamentais, endividamento e melhora com o retorno às atividades, ainda que de forma regular.

 

Palavras-chave: Turismo Religioso. Covid-19. Bares e Restaurantes. Festejo de São José de Ribamar.
O parentesco, sua força e possibilidades analíticas
Authors: Marques Heytor de Queiroz , Damásio Ana Clara , Venancio Vinícius
Published: December 2022

Neste trabalho apresentamos um pouco de nossas correntes teóricas e metodológicas sobre os estudos de parentesco, contribuindo com nossos modos de fazer antropologia, artigos que usaram das mais diversas possibilidade para analisar o parentesco. Com essa produção aprendemos sobre as mais diversas possibilidade e como são ricas as possibilidades aqui traçadas.
GEOGRAFIA DAS ARQUITETURAS: VULNERABILIZAÇÃO EM (DES)AÇÃO
Authors: Lopes José Lidemberg de Sousa
Published: December 2022

O presente paper é um recorte de uma palestra que ocorreu no dia 8 de novembro de 2019 no I Simpósio de Redução do Risco de Desastre na Região Nordeste e II Workshop do Grupo de Pesquisa em Gerenciamento dos Riscos e Desastres Naturais, ocorrido na Universidade Federal do Rio Grande do Norte, no Ceres, Campus de Caicó/RN. A palestra foi dividida em dois momentos. O primeiro ocorreu a explanação para o conhecimento das arquiteturas e o uso e abuso dos prédios antigos de cidades nordestinas como Rio Tinto no Estado da Paraíba; Aquiraz, Maranguape, Pacatuba e Icó no Ceará; Triunfo em Pernambuco; Oeiras no Piauí; Carolina no Maranhão e Caicó em terras potiguares. No segundo momento, tivemos um relato de experiência dos prédios antigos da cidade de União dos Palmares no Estado de Alagoas, onde se discutiu a importância histórica, as vulnerabilidades, o uso e abuso dos mesmos. A palestra finalizou com uma proposta de criação de um corredor cultural para a Rua Correia de Oliveira, antiga Rua da Batata, logradouro esse que encontramos o maior número de edifícios arquitetônicos da cidade. Com isso, o discurso sobre patrimônio cultural, memória e turismo foram fundamentais para discussão final da palestra em questão.
Desenvolvimento de uma aplicação web de mapeamento colaborativo para identificação de áreas de risco aplicada ao município de Nova Friburgo/RJ
Authors: Da Costa Lima Marciano , Peixoto Freiman Fabiano , Philippi Camboim Silvana
Published: December 2022

Com a crescente utilização de ambientes colaborativos virtuais visando alcançar diferentes objetivos, tem-se destacado o mapeamento colaborativo. Neste estudo visou-se desenvolver uma plataforma web de mapeamento colaborativo de pontos de alagamentos e deslizamentos no município de Nova Friburgo, Estado do Rio de Janeiro, Brasil. Com esta aplicação deseja-se que os próprios moradores da localidade possam realizar um trabalho crítico, tendo como finalidade a identificação de locais instáveis juntamente com a administração pública, permitindo-a realizar ações pontuais para a resolução dos problemas apontados pelos colaboradores da plataforma.
Vulnerabilidade Social da Cidade de Teresina, Piauí
Authors: Chaves Sammya Vanessa Vieira , Santos Laudenides  Pontes dos , Santos Francílio de Amorim dos , Vieira Valdira de Caldas Brito , Dantas Felipe Ramos
Published: December 2022

A ocupação desordenada das cidades brasileiras tem aumentado o número de pessoas afetadas por inundações, e a ocupação do leito maior dos rios urbanos por populações pobres tem contribuído para a agudização dos danos gerados. Estudos de vulnerabilidade socioambiental têm se tornado valioso instrumento na busca da mitigação dos efeitos das inundações, uma vez que aglutinam indicadores sociais, econômicos e ambientais, revelando a capacidade de resposta dos afetados para o enfrentamento dos desastres. Desse modo, objetivou-se, com o presente estudo, analisar a vulnerabilidade socioambiental de Teresina, Piauí, às recorrentes inundações. Para tanto, foram utilizados dados alfanuméricos de 11 variáveis, agrupadas em 4 critérios: demografia, educação, renda e condições habitacionais, para os 110 bairros do município de Teresina. A equação do índice de vulnerabilidade socioambiental (IVSA) para o município de Teresina se baseou em média aritmética simples. Os dados refinados das 11 variáveis e IVSA foram espacializados via ferramentas do QGIS. Constatou-se que os bairros Itararé, Angelim, Santo Antônio, Promorar e Mocambinho são os mais vulneráveis às inundações em Teresina, pois apresentaram baixos índices nas dimensões avaliadas, tornando essencial a intervenção do poder público sobre os mesmos, com o intuito de aumentar a capacidade de resposta mediante a materialização do desastre.

 Palavras-Chave: Vulnerabilidade. Inundação. Teresina.
Solos de tabuleiro do Recôncavo Baiano (Brasil): gênese, transformação e neotectonismo
Authors: Carvalho Claudia Csekö Nolasco de , Nunes Fábio Carvalho
Published: December 2022

Os Tabuleiros Costeiros constituem uma unidade geomorfológica desenvolvida sobre o Grupo Barreiras com grande extensão territorial no nordeste brasileiro. Os solos dessa unidade sustentam diversas atividades produtivas, mas apresentam complexos sistemas de transformação pedológica. O estudo genético desses solos permite compreender a dinâmica dos processos, possibilitando seu uso e manejo mais sustentável. Neste trabalho, através de análise topossequencial, procedeu-se a caracterização morfológica, micromorfológica, física, química e mineralógica dos solos para entender os processos de transformação Latossolo – Espodossolo com elevados teores de matéria orgânica desenvolvidos sobre os sedimentos do Grupo Barreiras em um tabuleiro do Recôncavo Baiano, no município de Santo Amaro, Brasil. O sistema pedológico é complexo, apresentando depressões relacionadas ao cruzamento de falhas e/ou fraturas que sugerem o neotectonismo como o processo que inicia a transformação pedológica. As relações entre o domínio latossólico e o hidromórfico apontam que a transformação dos latossolos é promovida por condições de saturação hídrica cíclicas e pela ação de compostos orgânicos de baixo peso molecular. Os elevados teores de matéria orgânica, acumulada por redução da mineralização sob condições ácidas e de anaerobiose temporária, propiciariam a evolução do húmus com a formação de compostos orgânicos móveis e ácidos que atuam na transformação dos Latossolos Amarelos, através da instalação de processos de podzolização com acidólise parcial de jusante para montante da vertente. Geoquimicamente a destruição de minerais primários e desorganização dos secundários indicam uma rota dominantemente orgânica no processo de transformação, sob influência de ambientes redutores.
Compartimentação das unidades de relevo e formas de uso da terra em um setor da escarpa oriental do Planalto da Borborema
Authors: Farias Paulo Lucas Cândido de , Corrêa Antônio Carlos de Barros , Ribeiro Simone Cardoso
Published: December 2022

O presente trabalho propõe uma compartimentação das unidades de relevo em um setor do Nordeste oriental brasileiro, com base na compartimentação geomorfológica como elemento chave para a estruturação da paisagem regional. Foi utilizada a proposta de mapeamento geomorfológico da União Geográfica Internacional (UGI) em meso-escala (Demek, 1972), que possibilitou uma análise integrada da paisagem que perpassa pelas geoformas, hipsometria, dados litoestratigráfico e aspectos físicos da rede de drenagem. Para o mapeamento de uso e cobertura da terra, foram utilizados os níveis de classe II e III do IBGE (Instituto Brasileiro de Geografia e Estatística). As unidades de relevo foram distribuídas a partir da ancoragem sobre duas morfoestruturas (o Planalto da Borborema e o seu Piemonte). No tocante ao modelado, foram identificadas cinco unidades de relevo, enquanto para as categorias de uso da terra, foram definidos cinco níveis de classes. Os resultados apontam uma relação sinérgica entre as unidades morfológicas, os tipos de uso e ocupação da terra predominantes e a morfodinâmica superficial resultante.
A CÂMARA DAS MARAVILHAS VIRTUAL CONTEMPORÂNEA
Authors: Hermogenes Almada Franco
Published: December 2022

A pandemia do Covid-10 causou a proibição dos eventos autônomos de música eletrônica na cidade de São Paulo no ano de 2020, de forma a afetar a manifestação da performance neste meio físico. Como solução tais artistas buscaram nas plataformas virtuais um espaço possível para manifestarem sua arte, mas nem sempre atentos as novas condições que este meio oferece. Este artigo chama a atenção dos leitores para reflexões sobre os efeitos da pandemia em seus corpos e performatividades. A partir da observação e crítica, o pesquisador busca compreender o funcionamento e efeitos desta migração e como os ruídos estéticos se constroem virtualmente. O isolamento e imanência encontram-se em um mesmo ambiente virtual, exposto e sob novos riscos que envolvem o domínio do meio.
Telejornal: a construção da notícia no texto sincrético
Authors: Diniz Maria Lúcia Vissotto Paiva , Araújo Juliano José de
Published: December 2022

O telejornal caracteriza-se como um texto sincrético, constituído por uma interação de linguagens (gestual, verbal, visual, sonora etc.), que instaura simulacros do Mundo natural, pois não pode abarcá-lo em toda a sua totalidade. Tendo como corpus duas reportagens transmitidas pelos telejornais Jornal Nacional e Jornal da Cultura objetiva-se investigar como se dá esse simulacro. Empregando a Semiótica francesa, estudaremos o plano do conteúdo, através da aplicação do instrumental semiótico, e algumas questões do plano da expressão (cores, enquadramento de câmeras, sonoplastia etc.). Consideraremos o telejornal enquanto gênero informativo de maior crédito, pertencente ao meio de maior poder de difusão e abrangência e que existe numa forma concreta: apresentado todas as noites na maioria dos canais. Como um ritual, os telejornais entram no ar na hora das refeições, daí as restrições éticas com relação ao público e as implicações persuasivas, estéticas e passionais que nos conquistam.

Palavras-chave: Enunciação. Sincretismo. Telejornal.
Descrição de algumas estratégias discursivas nos slogans publicitários: uma aplicação da teoria semiolingüística de Charaudeau
Authors: Othero Gabriel de Ávila
Published: December 2022

Este artigo trata de uma aplicação da teoria semiolingüística de Charaudeau na análise de slogans publicitários. Com base nas propostas de Charaudeau (1983a) e (1983b), alguns slogans publicitários brasileiros são analisados e discutidos. Além disso, são propostas algumas modificações na teoria original apresentada por Charaudeau, a fim de melhorar as análises dos slogans publicitários.

Palavras-chave: Semiolingüística. Análise Semiolingüística. Texto Publicitário.
Novel Nanotechnological Strategies for Skin Anti-aging
Authors: Domínguez-Delgado Clara Luisa , Pozos-Nonato Sara , Campos-Santander Kenia Areli , Benavides Allyson Amelia , Pacheco-Ortin Sandy María , Higuera-Piedrahita Rosa Isabel , Resendiz-González Guillermo , Molina-Trinidad Eva María
Published: December 2022

Background:

Nanoparticle formulations development for anti-aging treatment is increasing due to their multifunctional properties. These nanotechnological strategies can target cellular/ molecular pathways of the skin affected by the aging process. However, a review of these strategies is required to discuss their efficacy/safety and establish the needs for further research.

Objective:

Innovative nanotechnological advances for skin anti-aging/rejuvenation are summarized and discussed in this work.

Method:

The information in this review was extracted from recent and relevant studies using nanotechnology for anti-aging treatment from scientific databases.

Results and Discussion:

Results show an enhanced skin anti-aging effect of actives-loaded nanoparticles of next generation (nanostructured lipid carriers, fullerenes, transfersomes, protransfersomes, niosomes, ethosomes, transethosomes, glycerosomes, phytosomes) compared with nanocarriers of first generation or conventional formulations. Anti-aging active ingredients such as, flavonoids (rutin, hesperidin, quercetagetine, quercetin, epigallocatechin-3-gallate, myricetin, silibinin, curcuminoids, isoflavones); vitamins (E, D3, CoQ10); acids (hyaluronic, ascorbic, rosmarinic, gallic); extracts (Citrus sinensis, Tagetes erecta L., Achillea millefolium L., Citrus aurantium L., Glycyrrhiza glabra L., Aloe vera, propolis earned by Apis mellifera); and other compounds (adenosine, beta-glucan, heptapetide DEETGEF, resveratrol, cycloastragenol, melatonin, botulinum toxin, grapeseed oil), have been successfully entrapped into nanoparticles for skin rejuvenation. This encapsulation has improved their solubility, bioavailability, stability, permeability, and effectivity for skin anti-aging, providing a controlled drug release with minimized side effects.

Conclusion:

Recent studies show a trend of anti-aging herbal active ingredients-loaded nanoparticles, enhancing the moisturizing, antioxidant, regenerating and photoprotective activity of the skin. Suitable safety/shelf-life stability of these novel formulations is key to a successful translation to the clinic/industry.
Monitoring Shrimp Spoilage Using a Paper-based Colorimetric Label
Containing Roselle Flower Extract
Authors: Fauzia Vivi , Listyarini Arie , Imawan Cuk , Djuhana Dede
Published: December 2022

Background:

Intelligent food packaging that can monitor food quality and safety is
essential in modern commercial trade. Research on the fabrication of environmentally friendly
colorimetric labels that can indicate the freshness of food through color changes are needed.

Methods:

In this study, paper-based colorimetric labels were prepared using filter paper dipped
into a solution of Roselle flower extract, and their performance in monitoring shrimp spoilage
was investigated.

Results:

The labels’ response to ammonia vapor shows a distinct color variation from red to
greenish-grey, corresponding to a sharp increase in the total color difference (ΔE = 32). The labels
are relatively stable during storage at 4°C for up to 20 days. In shrimp freshness monitoring,
the color changes from red to purple, which corresponds to increasing levels of total volatile
basic nitrogen (TVB-N), and can be observed easily with the naked eye.

Conclusion:

This suggests that our paper-based colorimetric labels impregnated with Roselle
extract show superior performance in detecting shrimp spoilage.
Diagnosis and Management of Supine and Nocturnal Hypertension in
Orthostatic Hypotension: A Review
Authors: Aravinthan Prassana , Aravinthan Trilochan , Anpalahan Aksharaa , Anpalahan Mahesan
Published: December 2022

The prevalence of supine and nocturnal hypertension (S-N-HT) is high among patients
with orthostatic hypotension (OH), especially in those who have a neurogenic aetiology.
The evidence suggests that S-N-HT exacerbates OH, although it is unclear whether pharmacologic
treatment of S-N-HT will improve OH. S-N-HT has also been associated with target organ
damage. Therefore, assessment and management of S-N-HT should be an integral part of
managing OH, but it is often overlooked in clinical practice.
Metabolomics-based Approach to Analyze the Therapeutic Targets and
Metabolites of a Synovitis Ointment for Knee Osteoarthritis
Authors: Zhang Lei , Yang Huan , Liu Jing , Wang Ke , Cai Xiang , Xiao Wei , Wang Le , Wang Mang , Zhang Chi , Zhang Jin
Published: December 2022

Background:

Knee osteoarthritis (KOA) is a clinically common degenerative joint disease
that is not fatal but has a high prevalence. Synovitis ointment (HMYG) is a traditional Chinese medicine
formula that has been clinically proven to treat KOA; however, its therapeutic targets remain unknown.

Objective:

This study aimed to identify metabolites and potential targets of synovitis ointment alleviation
in rats with KOA using ultra-high-performance liquid-chromatography–mass spectrometry
(UHPLC-MS) metabolomics.

Methods:

The meniscus on each side of the knee was removed to model KOA in rats. The synovitis
ointment treatment was provided for 4 weeks. The lateral diameter of the knee was measured once a
week, and after 4 weeks, serum was collected to observe changes in the knee through a metabolomic
analysis.

Results:

Synovitis ointment reduced the lateral diameter of the knee joint, relieved knee swelling, and
improved knee volume. In total, 28 differential metabolites, which were mainly involved in arginine
and proline metabolism and apoptosis, were identified in the Con and HMYG groups. 15-Deoxy-d-12,
14-PGJ2 and fomepizole were found to be the key metabolites after the HMYG treatment of KOA.
Compared with known drugs (diclofenac diethylamine emulsion and Jin Huang San), 2-(SGlutathionyl)
acetyl glutathione, daidzein, pelargonic acid, and sulfamethoxazole increased in the
HMYG, and the metabolic pathways included the oxytocin signaling pathway, platelet activation, olfactory
transduction, phototransduction, and cGMP-PKG signaling pathway. The expression levels of
cleaved-caspase-3, Bcl-2, PIK3a, TP53, TGFB1, and NFKB1 were reversed after HMYG treatment.

Conclusion:

It has been observed that synovitis ointment relieves KOA. UHPLC-MS can analyze the
potential mechanism of action of the herbal compound of the synovitis ointment.
Signalling Pathways Involved in Microglial Activation in Alzheimer’s
Disease and Potential Neuroprotective Role of Phytoconstituents
Authors: Ali Mohd Uzair , Anwar Laiba , Ali Mohd Humair , Iqubal Mohammad Kashif , Iqubal Ashif , Baboota Sanjula , Ali Javed
Published: December 2022

Alzheimer’s disease (AD) is a commonly reported neurodegenerative disorder associated
with dementia and cognitive impairment. The pathophysiology of AD comprises Aβ, hyperphosphorylated
tau protein formation, abrupt cholinergic cascade, oxidative stress, neuronal apoptosis, and neuroinflammation.
Recent findings have established the profound role of immunological dysfunction and
microglial activation in the pathogenesis of AD. Microglial activation is a multifactorial cascade encompassing
various signalling molecules and pathways such as Nrf2/NLRP3/NF-kB/p38 MAPKs/
GSK-3β. Additionally, deposited Aβ or tau protein triggers microglial activation and accelerates its
pathogenesis. Currently, the FDA-approved therapeutic regimens are based on the modulation of the
cholinergic system, and recently, one more drug, aducanumab, has been approved by the FDA. On the
one hand, these drugs only offer symptomatic relief and not a cure for AD. Additionally, no targetedbased
microglial medicines are available for treating and managing AD. On the other hand, various
natural products have been explored for the possible anti-Alzheimer effect via targeting microglial activation
or different targets of microglial activation. Therefore, the present review focuses on exploring
the mechanism and associated signalling related to microglial activation and a detailed description of
various natural products that have previously been reported with anti-Alzheimer’s effect via mitigation
of microglial activation. Additionally, we have discussed the various patents and clinical trials related
to managing and treating AD.
Histopathological Findings of Oral Mucosa in Smokeless Tobacco Users: Case Report
Authors: Miļuna Sintija , Melderis Ričards , Sperga Māris , Skadiņš Ingus , Kroiča Juta , Rostoka Dagnija
Published: December 2022

Background:

New tobacco products, such as smokeless tobacco, are becoming more popular every year. In talking with our patients, we determined several reasons for that trend. The sale of these products is prohibited in many countries; hence, people obtain the product illegally. This is important, since when these products are stored under inappropriate conditions and temperatures, the quality and properties of the product change, including their carcinogenic properties. Sometimes people use a lot of this product or more than one tobacco product daily. It is challenging for dental practitioners to question their patients about tobacco consumption and more challenging to visually detect oral mucosal changes, because patients usually do not have concerns or they do not pay attention.

Methods:

In the two cases presented here, the patients did not have any pain, nor did they notice when the lesions appeared. These patients used conventional cigarettes for some time and then switched to smokeless tobacco due to relocation to Latvia. Soft tissue excision was performed and sent for histopathological examination.

Results:

The findings were proliferation of oral epithelial cells from buccal region, their overgrowth, an excessive amount of fibroblasts, cell destruction and necrosis, and a large amount of inflammatory cells, eosinophil leukocytes, and plasma cells.

Conclusion:

We can conclude that these intraoral findings are important risk factors for possibly developing precancerous lesions. Such mucosal changes can occur with different forms of tobacco, including Swedish snus and betel leaves. Dental practitioners should always question patients about tobacco use and regularly check for mucosal changes for early detection.
Thoracolumbar Interfascial Plane Block (TLIP) Modified Technique for Lumbar Decompression Surgery in Cirrhotic Hepatic Patients with Thrombocytopenia: A Case Report
Authors: Tantri Aida Rosita , Natali Christella , Soebroto Erlina , Ferdiana Komang Ayu
Published: December 2022

Introduction:

As one of the top ranks in the pain-producing procedure, spinal surgery requires adequate perioperative pain management to improve outcomes. Likewise, perioperative pain management in cirrhotic hepatic thrombocytopenia patients is challenging. Modified TLIP block can be an option for perioperative pain management in the lumbar decompression surgery for a cirrhotic hepatic patient with thrombocytopenia.

Case Presentation:

A man, 67 years old, who suffered from cirrhosis hepatic with thrombocytopenia underwent endoscopic spinal decompression with laminotomy and flavectomy of L4-L5. After induction of general anesthesia with midazolam 1,5 mg, fentanyl 150 mcg, propofol 100 mg, and rocuronium 1mg/kg, the patient was intubated. The lungs were ventilated with a pressure control mode with tidal volume 8 ml/kg BW, respiratory rate 12/min, and PEEP 5 cm H2O with FiO2 50%. and 1% sevoflurane. Modified TLIP block was performed at the L3 level. Twenty ml of bupivacaine 0,5% was administered between the longissimus and iliocostalis muscles on both sides.

Results:

Intraoperative, modified TLIP block provide adequate analgesia with stable hemodynamics. The visual Analog Scale (VAS) of pain was 1-2 in 24h postoperative. No additional opioid was required within 24 hours postoperatively. There were no neurological complications or bleeding due to the modified TLIP block found in this patient.

Conclusion:

Modified TLIP block can be an effective and safe analgesic technique for hepatic cirrhosis patients with thrombocytopenia. However, further research is needed to determine the safety limits of modified TLIP block in patients with coagulation disorder or anticoagulant use.
Relationship between the Prevalence of Glaucoma (Estimated Through Prescribed Antiglaucomatous Medication) and Access to Ophthalmologists in Norway
Authors: Slettedal Jon Klokk , Traustadóttir Valgerður Dóra , Sandvik Leiv , Ringvold Amund
Published: December 2022

Purpose

The relationship between supply and demand in health-care is a challenge. The purpose of the present study is to evaluate to what extent glaucoma prevalence is influenced by local access to eye health-care service in Norway.

Methods

Population-based cross-sectional study. Data from The Norwegian Prescription Database was used to find the number of users of topical glaucoma medication, grouped by age and county, giving an estimate of glaucoma prevalence. The number of registered ophthalmologists and opticians was obtained from The Norwegian Society of Ophthalmologists and The Norwegian Directorate of Health.

Results

In total, 75733 persons were treated with IOP-lowering drugs in Norway in 2018, suggesting an overall glaucoma prevalence of 1.43%. In the age group 70-89 years, the nationwide prevalence was 7.60%, the lowest prevalence being in Oppland (5.98%) and highest in Aust-Agder (9.28%) counties. The number of ophthalmologists per 100000 inhabitants varied from 2.63 to 14.65 in the various counties. A statistically significant correlation was found between glaucoma prevalence in the age group 70-89 years and access to ophthalmological services. Furthermore, the increase in glaucoma prevalence plateaus at roughly 10 ophthalmologists per 100000 inhabitants, indicating that this could cover population demands. This relationship did not apply for opticians.

Conclusions

There is a clear correlation between glaucoma prevalence and availability of ophthalmologists in various counties in Norway. Our study indicates a direct relationship between the number of ophthalmologists in the area and the number of people being treated for glaucoma, with prevalence plateauing once a threshold of approximately 10 ophthalmologists per 100000 inhabitants is reached. This finding suggests that low glaucoma prevalence in some regions could be due to limited access to ophthalmological services.
High Prevalence of Lower Extremity Medial Arterial Calcification in HIV-infected Patients With and Without Chronic Renal Disease: A Vascular Ultrasound Cross-sectional Study
Authors: Višković Klaudija , Marinelli Annibale , Nedeljko Katrin , Bržan Petra Povalej , Bogdanić Nikolina , Begovac Josip
Published: December 2022

Background:

The association between HIV infection and increased risk of atherosclerotic peripheral artery disease (PAD) has been documented. Still, the relationship between HIV infection and lower extremity medial arterial calcification (MAC) is unknown.

Objective:

We performed a cross-sectional study to compare the frequency of MAC diagnosed by vascular ultrasound in PAD-asymptomatic people living with HIV (PLWH) with and without chronic kidney disease (CKD) compared to HIV-uninfected participants as a control group.

Methods:

MAC was defined as smooth, linear, and non-stenotic hyperechogenicity in the arterial wall compared to the surrounding tissues. We studied 191 patients: 50 PLWH (25 with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73m2 and 25 with an eGFR <60 mL/min/1.73m2) and 141 HIV-uninfected patients (68 with eGFR<60 ml/min/1.73m2).

Results:

MAC was most frequently found in PLWH with CKD (76%). The prevalence of MAC among PLWH was 54.0% (95% confidence interval [CI], 40.4-67.0%), whereas, in HIV-uninfected, it was 34.0% (95% CI, 26.7-42.2%, P=0.013). Age and CKD were consistently associated with MAC in our multivariable models, and there was also a sign that PLWH had higher odds of having MAC.

Conclusion:

We found a higher prevalence of MAC in PAD-asymptomatic PLWH compared to HIV-uninfected ones and provided evidence that HIV infection could be associated with MAC.
Management of Mental Health Problem among Primary School Teachers using Rational-emotive Behavior Therapy
Authors: Ugwuanyi Christian S.
Published: December 2022

Background:

Teachers in the Nigerian education system, especially at the primary level, experience various mental health issues. This is likely to be so as primary school teachers carry out a lot of responsibilities ranging from teaching all the primary school subjects to taking care of their families. Studies have revealed that mental health issues limit the academic responsibilities of teachers. However, there is a dearth of literature on mental health issues management among primary school teachers.

Objective:

This study explored the effect of rational-emotive behavior therapy (REBT) on work stress management among primary school teachers.

Methods:

Using a randomised control trial group experimental design, this research used 45 primary school teachers as the study participants. Data for the study were collected using a work stress questionnaire which was properly validated and trial tested (α = .84). The participants were pretested before being exposed to a 12-week REBT intervention treatment. Participants were then retested and received follow-up care two months after the end of the intervention. Data collected were analysed using mixed-design repeated analysis of variance.

Results:

It was revealed that the work stress of the primary school teachers who were exposed to REBT intervention significantly (p < .05) reduced after the treatment.

Conclusion:

REBT intervention significantly affected work stress management among primary school teachers. Therefore, it was recommended that REBT intervention be used as a workplace stress management intervention among primary school teachers.
microRNA-146a: A Biomarker for Epileptogenesis, Epilepsy Prognosis, and Treatment Resistance
Authors: Dent Zachary O. , Chen Liam
Published: December 2022

Recently, more attention has been paid to identifying biomarkers for epilepsy to direct a more personalized treatment strategy, especially for patients who suffer from drug-resistant epilepsy which carries a much poorer prognosis. microRNA has emerged as an important and diverse type of biomarker that can participate in metabolic and cellular processes of the disease and, importantly, can be detected in patient’s serum. In this short review, we compile state-of-the-art evidence regarding miRNA-146a, a novel biomarker that shows high potential for studying epileptogenesis, monitoring disease progression, evaluating treatment response, and may even function as a therapeutic target given its role in the process of neuroinflammation.
A Simple and Modified One Pot Conversion of Carboxylic Acid to Ketone
Authors: Sahoo Debasis , Jana Samaresh , Sahoo Sharmistha
Published: December 2022

Background:

Ketone is one of the important functional groups in synthetic chemistry.
For this reason, organic chemists focused on the synthesis of ketone starting from various functionalities
since nineties. One of the method deals with the conversion of carboxylic acids to ketones
in a one pot manner. We have recently reported a one pot transformation of carboxylic acid
to ketone using TsCl or MsCl as an activator of carboxylc acid. In our previous reports, two equivalents
of organometallic reagent have been used which may not be useful in medicinal chemistry.
In this report, we have developed an alternative process for the transformation where only one
equivalent of organometallic reagent has been employed.

Objective:

In present scenario, we are interested to develop a process for the transformation of
carboxylic acid to ketone using one equivalent of an organometallic reagent.

Methods:

A carboxylic acid reacted with tosyl chloride in the presence of a sodium hydride to
form a mixed anhydride. Here, the acidic proton was removed from the reaction mixture as hydrogen
gas. This mixed anhydride was then treated with one equivalent of an organomagnesium reagent
at -30°C to obtain the desired ketone.

Results:

Following the optimum conditions, a few commercially available carboxylic acids were
treated with TsCl, followed by the treatment of phenyl magnesium and methyl magnesium bromide
to obtain phenyl and methyl ketones, respectively, in good to excellent yields.

Conclusion:

A simple and modified one pot method for the conversion of carboxylic acids to ketone
has been reported. In this developed process, one equivalent of the organomagnesium reagent
has been used to obtain the desired ketone under the optimized reaction conditions.
Semiotic study of idioms related to the royal court of Danxome in Benin Republic (ex Dahomey)
Authors: Datondji André Cocou , Effiboley Emery Patrick
Published: December 2022

This paper undertook a semiotic analysis and interpretation of idiomatic expressions that were used in the former royal court of Danxome in Republic of Benin (Ex Dahomey). The qualitative analysis based on the Saussurian and Piercian views on semiotics was applied on a corpus of idioms collected from primary sources with close links with descendants of the kingdom. The results achieved were forceful in disclosing three main patterns of the analysed idioms. First, they uncovered the presence of culturally loaded idiomatic centres that represent the keys to unlocking the intended meanings therein contained. Secondly, the very phrasing of some of the idioms displayed the hierarchical organisation that was intrinsic to the royal court. Thirdly, a further investigation into their intended content disclosed an association of both spoken and sign language in the delivery of the message conveyed through some specific idiomatic expressions of the royal court of Danxome. These results led to the conclusion that the idioms used in this royal court were more than mere language for daily ordinary interactions. Rather, they represented real artefacts, encapsulating the culture, the history and the social relationships that best represent and portray such a restricted social and linguistic community.