bluuebunny/crossref_metadata_2025 huggingface dataset:
TUMOR INFLATING LYMPHOCYTES. PURIFICATION, EXPANDING AND CYTOTOXICITY ANALISYS ON PRIMARY TUMOR CULTURES
Authors: Yusubalieva Gaukhar , Petrichuk Svetlana , Krivoshapkin Alex , Kedrova Anna , Ivanov Yuriy , Vinokurov Alex , Kalinkin Alex , Sanzharov Andrey , Kim Sergio , Kuptsova Daria , Ponomarev Arthur , Ischenko Roman , Troitskiy Alexander , Baklaushev Vladimir
Published: May 2020

Tumor Infiltrating Lymphocytes (TILs) is one of the most promising sources of autologous cytotoxic T-cells for adoptive immunotherapy, which has already shown high efficiency in the treatment of metastatic melanoma. In this study, we isolated TILs from surgical material obtained by resection of solid tumors (primary and metastatic adenocarcinomas of various localization, melanoma, glioblastoma), studied their population composition and developed protocols for the purification expanding, and activation of CD4 +, CD8 + cytotoxic antitumor lymphocytes. Cells were obtained from samples of resected tumors in 15 patients; in each case we obtain an autologous pair: the primary tumor culture and the TILs culture. We could isolate viable lymphocytes in 100% of cases. Isolated TILs were successfully expanded in our specialized medium using various combinations of IL-2 / IL-15 / IL-21 // IL-7, anti-CD3 and anti-CD28. Immunophenotyping showed that the obtained TILs are a heterogeneous mixture of CD4 +, CD8 + cells containing populations of CD3 +, CD4, CD8 cells, CD4 + CD25 + CD127 T-regulatory cells, CD45RA, CCR7 + memory T-cells, CD56 + CD16- NK cells. The initial cultures of TILs were also characterized by a high level of PD1 expression, indicating their low antitumor cytotoxicity. Using different protocols of isolation, expansion, and activation, we obtained a cell preparation containing 80% of CD8+ PD1 activated TILs in an amount sufficient for adoptive therapy (500106 or more). An in vitro study of the cytotoxicity of obtained TILs in primary cultures of homologous tumors using RTCA Icelligence showed high cytotoxicity, providing almost 100% tumor cell death. Our developed protocol for the production and activation of TILs can be recommended for the phase I-II clinical trials of adoptive immunotherapy of recurrent, highly metastatic solid tumors.
Non-Double-Couple Components of the Moment Tensor in a Transversely Isotropic Medium
Authors: Menke William , Russell Joshua B.
Published: May 2020

The non-double-couple (non-DC) components of the moment tensor provide insight into the earthquake processes and anisotropy of the near-source region. We investigate the behavior of the isotropic (ISO) and compensated linear vector dipole (CLVD) components of the moment tensor for shear faulting in a transversely ISO medium with an arbitrarily oriented symmetry axis. Analytic formulas for ISO and CLVD depend on the orientation of the fault relative to the anisotropy symmetry axis as well as three anisotropic parameters, which describe deviations of the medium from isotropy. Numerical experiments are presented for the preliminary reference Earth model. Both ISO and CLVD components are zero when the axis of symmetry is within the fault plane or the auxiliary plane. For any orientation in which the ISO component is zero, the CLVD component is also zero, but the opposite is not always true (e.g., for strong anisotropy). The relative signs of the non-DC components of neighboring earthquakes may help distinguish source processes from source-region anisotropy. We prove that an inversion of ISO and CLVD components of a set of earthquakes with different focal mechanisms can uniquely determine the orientation and strength of anisotropy. This study highlights the importance of the ISO component for constraining deep slab anisotropy and demonstrates that it cannot be neglected.
Contributions to Achenium Leach, 1819 (Coleoptera, Staphylinidae, Paederinae) fauna of Turkey
Authors: AYAN İnanç , ANLAŞ Sinan
Published: May 2020

In this study, total of 388 specimens of the genus Achenium Leach, 1819 (Coleoptera: Staphylinidae) were collected by aspirator and sifter methods from different provinces of Aegean and Central Anatolia Regions of Turkey between 2014 and 2019. As a result of the field studies, five species of the genus were recorded. These species wereAchenium anatolicum Jarrige, 1952; A. humile (Nicolai, 1822); A. propontiacum Bordoni, 2009; A. scimbalioides Koch, 1937 and A. turcicum Coiffait, 1971. Of the recorded species; A. humile from the Aegean Region and A. turcicum from Central Anatolia Region were the first recorded for the area. A. turcicum was reported for the first time outside the type locality and its distribution was found to be much wider than previously known. A. turcicum and A. anatolicum were the endemic species for Anatolia.
Ana Ürün Olarak Yetiştirilen Bazı Soya Fasulyesi (Glycine max. (L.) Merrill) Çeşitlerinin Önemli Kalite Özelliklerinin Belirlenmesi
Authors: KAYA Ali Rahmi
Published: May 2020

Bu araştırma, Kahramanmaraş şartlarında ana ürün olarak yetiştirilen 12 soya fasulyesi (Glycine max (L.) Merrill) çeşidinde kalite özelliklerini belirlemek amacıyla yapılmıştır. Çalışma Kahramanmaraş Doğu Akdeniz Geçit Kuşağı Tarımsal Araştırma Enstitüsü deneme arazisinde 2016 yılında yürütülmüştür. Denemede materyal olarak Arısoy, Atakişi, Ataem, Bravo, Cinsoy, Çetinbey, May 5312, May 5414, Nova, SA 88, Türksoy ve Umut soya fasulyesi çeşitleri kullanılmıştır. Denemede yağ oranı, miristik asit oranı, palmitik asit oranı, palmiteloik asit oranı, heptadekanoik asit oranı, stearik asit oranı, oleik asit oranı, linoleik asit oranı, linolenik asit oranı, araşidik asit oranı, behenik asit oranı ve lignoserik asit oranı, yağ stabilite değerlerinden oleik asit/linoleik asit oranı, iyodin değeri, dane verimi ve yüz dane ağırlığı incelenmiştir. Çalışma sonucunda, soya fasulyesi çeşitlerinde yağ oranı, oleik asit, linoleik asit, linolenik asit ve tohum verimi gibi incelenen bazı önemli özelliklere ait değerlerin sırasıyla, %18.003 - 23.303, %22.115 - 26.254, %51.240 - 55.505, %6.534 - 7.560 ve 1705 - 3285 kg ha-1 arasında değiştiği saptanmıştır. Çeşitler arasındaki farklılıkların incelenen tüm özellikler için çok önemli olduğu bulunmuştur. Yağ oranı (%23.303) en yüksek bulunan Ataem çeşidinde palmiteloik asit (%0.088), oleik asit (%26.254), araşidik asit (%0.186) ve O/L değeri (%0.513) en yüksek bulunurken, stearik asit (4.306) ve behenik asit (%0.353) bakımından ise çeşitler arasında ikinci sırada yer almıştır. Çalışma sonucunda Mayıs 5414 çeşidinde dane verimi (3145 kg ha-1), heptadekanoik asit (%0.086), linoleik asit (%55.505) ve iyot değeri (115.16) en yüksek iken TU 88 çeşidinde miristik asit (%0.067), palmitik asit (%11.026) ve behenik asit (%0.355) en yüksek bulunmuştur.
Selective Cytotoxic Effect of Astaxanthin on Human Lung and Colon Cancer Cells
Authors: DEMİR Selim , AYAZOGLU DEMİR Elif , ALİYAZICIOĞLU Yüksel
Published: May 2020

Astaxanthin (ASX) is a red xanthophyll carotenoid found in various microorganisms and marine animals. ASX is also called the "super antioxidant" because it has the highest antioxidant activity among existing carotenoids. Studies have shown not only antioxidant properties but also antimicrobial, immunomodulatory, hepatoprotective, anticancer and antidiabetic properties of ASX. However, there is a limited number of studies examining the selective cytotoxic effects of ASX on cancer cells. The aim of this study was to determine the cytotoxic effects of ASX on cells representing common cancer types. For this, human breast (MCF-7), lung (A549), liver (HepG2), melanoma (VMM917), colon (WiDr) cancer and normal fibroblast cells were treated with different concentrations of ASX for 72 h and then the MTT assay protocol was applied. Cisplatin was used as a positive control in cytotoxicity experiments. The results showed that ASX had a dose-dependent cytotoxic effect on all studied cancer cell lines. However, the strongest selective cytotoxic effect of ASX was determined in A549 and WiDr cells compared to fibroblast cells. This study shows that selective cytotoxic effect of ASX should be investigated more extensively, especially in terms of lung and colon cancer.
De rekbare waarheid
Authors: Harbers Frank
Published: May 2020

Review of: Taco Rijssemus, De rekbare waarheid. Over de objectiviteit van betrokken journalistiek(Amsterdam University Press) 2014, 234 pp. ISBN 9789089647108
Primer Simposio de Suelos y Nutrición de Cultivos
Authors: Caviedes Mario , Gangotena Diego , Albán Gabriela , León Antonio
Published: May 2020

Primer Simposio de Suelos y Nutrición de Cultivos
Educación en Competencias Financieras, Administrativas y de Marketing para la Comunidad
Authors: Abad Candy , Valencia Paola
Published: May 2020

Educación en Competencias Financieras, Administrativas y de Marketing para la Comunidad
Memorias del Segundo Congreso Nacional de Microbiología Molecular y Aplicada
Authors: Machado Antonio , Valencia David
Published: May 2020

Memorias del Segundo Congreso Nacional de Microbiología Molecular y Aplicada
Archivos académicos 26
Authors: Valencia Gonzaga Eduardo David
Published: May 2020

Resumen
Memorias del II Simposio Latinoamericano de Aplicaciones Nucleares en la Agricultura
Authors: Alban Gabriela , Caviedes Mario , Ponce Luis , Zambrano José Luis
Published: May 2020

Memorias del II Simposio Latinoamericano de Aplicaciones Nucleares en la Agricultura
Resúmenes de la IV Reunión Ecuatoriana de Ornitología
Authors: Cisneros-Heredia Diego F. , Freile Juan , Guevara Esteban
Published: May 2020

Resúmenes de la IV Reunión Ecuatoriana de Ornitología
Resúmenes del Segundo Simposio de Fitopatologìa, Control Biològico e Interacciones Planta-Patogeno
Authors: León Antonio , Barriga Noelia
Published: May 2020

Resúmenes del Segundo Simposio de Fitopatologìa, Control Biològico e Interacciones Planta-Patogeno
Memorias del 1er Simposio de Investigación & Conservación Galápagos GSC-DPNG / 1st Galapagos Conservation & Research Symposium GSC-DPNG
Authors: Muñoz-Pérez Juan Pablo , Tacle Sofía
Published: May 2020

Memorias del 1er Simposio de Investigación & Conservación Galápagos GSC-DPNG / 1st Galapagos Conservation & Research Symposium GSC-DPNG
Memorias de la XXII Reunión Latinoamericana del Maíz
Authors: León Antonio , Caviedes Mario , Albán Gabriela
Published: May 2020

Memorias de la XXII Reunión Latinoamericana del Maíz
Jus Post Bellum: ¿Qué tan útil es para las Relaciones Internacionales?
Authors: Mendizabal Santiago
Published: May 2020

El siguiente artículo analiza la aplicación de Jus Post Bellum, un concepto derivado de la teoría de la Guerra Justa de Michael Walzer. En primer lugar, se concede una definición de la teoría de la guerra Justa a partir de los enunciados de Williams y Caldwell. Luego, se explica Jus Post Bellum, esto incluye obligaciones que tienen los Estados al momento de intervenir. A continuación, se destacan varios casos en los cuales, Estados Unidos se adhirió a los principios de Jus Post Bellum. Y, después, situaciones en las cuales no lo hizo. Finalmente se utilizan estos ejemplos para explicar cómo ha cambiado la moralidad de los estados a través del tiempo.
Adherencia y potenciales eventos adversos prevenidos durante la administración de medicamentos endovenosos empleando bombas de infusión inteligentes en cuatro unidades de cuidados intensivos en Colombia
Authors: López-Romero Luis Alberto , Cáceres Rivera Diana Isabel , Dueñas Badillo Ruby Emilse , Acosta-Barón Jennifer Vanesa , Robles Méndez Ismery Yaneth , Rincón Castillo Diego , Parra de Rey Gloria Isabel
Published: May 2020

Introducción: Las bombas de infusión inteligentes, constituyen una herramienta útil para la administración segura de medicamentos endovenosos dado que permiten prevenir potenciales eventos adversos. Objetivo: Evaluar la adherencia y los potenciales eventos adversos prevenidos, durante la administración de medicamentos endovenosos empleando bombas de infusión inteligentes. Metodología: Estudio observacional, realizado en cuatro unidades de cuidados intensivos usando datos del software Hospira MedNetTM. Un análisis descriptivo fue llevado a cabo junto con un análisis bivariado empleando una prueba U de Mann-Whitney, una prueba de Kruskal-Wallis y un test de Bonferroni para evaluar la adherencia y los potenciales eventos adversos prevenidos por año y servicio. Resultados: La adherencia fue del 74,0%, se presentaron 78.299 alertas de seguridad y se previnieron 4,54% (n=16.288) potenciales eventos adversos. Se encontraron diferencias entre el primer y segundo año en la adherencia [Mediana: 69,15 (Q1:64,2-Q3:75,5) Vs Mediana: 84,2(Q1:72,15-Q3:89,05), p<0.001], adherencia a la seguridad [Mediana: 87,1% (Q1:83,05-Q3:91,2) Vs Mediana: 94,05 (Q1:89,95-Q3:96,2), p<0.001] y las ediciones de alertas de limite relativo [Mediana:17,0 (Q1:8,5-Q3:24,5) Vs Mediana: 12,0 (Q1:7,0-Q3:17,5), p=0.013]. La solución salina, la norepinefrina, el lactato de ringer, la piperacilina-tazobactam, la nitroglicerina y la heparina presentaron el mayor número de alertas de seguridad. Conclusión: Se encontró una buena adherencia (uso de la farmacoteca) y adherencia a la seguridad (indicador de uso de la bomba), con una reducción de los potenciales eventos adversos; así el uso de bombas inteligentes podría contribuir en la prevención de potenciales errores durante la administración de medicamentos endovenosos en la unidad de cuidados intensivos.
Modelo médico hegemónico: tendencias posibles y tendencias más o menos imaginarias
Authors: Menéndez Eduardo L.
Published: May 2020

El objetivo de este texto es analizar la posibilidad futura de que el modelo médico hegemónico siga perpetuándose o se generen cambios significativos. Para ello se parte de las características y funciones actuales del modelo médico hegemónico, y se las observa a través de algunos de los aportes de la inteligencia artificial, de las investigaciones genéticas, de la robótica referidas a procesos de salud-enfermedad-atención-prevención, entre los que se analizan las posibilidades de fuertes incrementos en la esperanza de vida, las necesidades de “curar la senectud”, así como los procesos que están modificando la relación médico-paciente, llegando a la conclusión de que si bien se observan algunas modificaciones sustantivas, las características y funciones del modelo médico hegemónico siguen siendo las mismas.
The relation among tinnitus distress, psychoacoustic parameters and anxiety state in hearing-impaired patients with chronic tinnitus: a pilot study
Authors: Sharafi Mohammad Amin , Farahani Saied , Hoseinabadi Reza , Zamiri Abdollahi Farzaneh , Jalaie Shohreh , Etemadi Maryam
Published: May 2020

Background and Aim: Anxiety and depression are prevalent psychological disorders accompany tinnitus that have adverse effects on quality of life of these patients and on the outcomes of rehabilitation programs. The goal of this study was determining and quantifying the relation among perceived tinnitus severity, its psycho­acoustic parameters and anxiety symptoms in hearing-impaired individuals with subjective chronic tinnitus and residual inhibition (RI) by using Persian version of Spielberger's State-Trait Anxiety Inventory (STAI), tinnitus handi­cap inventory-Persian version (THI-P) and visual analogue scale (VAS) besides psychometric evaluations.
Methods: Fourteen patients with chronic tinnitus were enrolled in this cross-sectional study. Con­ventional psychoacoustic tinnitus evaluations (i.e. determining quality of tinnitus, pitch match­ing, loudness matching, minimum masking level and RI) were conducted for all subjects, and they also completed the Persian version of STAI and THI-P. For screening of tinnitus perceived loud­ness and distress, VAS was used.
Results: There was no correlation among THI-P, VAS scores and psychoacoustic parameters. There was a positive significant correlation bet­ween THI-P and Persian STAI scores (r = 0.63; p = 0.01). There was not any significant corre­lation between tinnitus duration and VAS, STAI or THI-P. There also had no significant corre­lation between VAS and THI-P (r = 0.56; p = 0.2).
Conclusion: The present pilot study showed that Persian version of THI and STAI are corre­lated questionnaires. Therefore, Persian version of these questionnaires are valuable tools for evaluation of patients with chronic tinnitus.
Keywords: Anxiety; tinnitus; tinnitus handicap inventory; state-trait anxiety inventory; visual analog scale; psychoacoustics
Nutrition and Infection with COVID-19
Authors: Khayyatzadeh Sayyed Saeid
Published: May 2020

This article is an Editorial and does not include an Abstract.
The Association between Dietary Intakes and Differentiated Thyroid Cancer: A Cross-Sectional Study among Patients and Healthy People in Iran
Authors: Sangsefidi Zohreh Sadat , Norouzy Abdolreza , Safarian Mohammad , Kashanifar Roxana , Pourbaferani Raheleh , Ghafouri-Taleghani Fateme , Fallahi Sahar , Taghizadeh Kermani Ali , Zakavi Seyed Rasoul
Published: May 2020

Background: Differentiated thyroid cancer (DTC) is the most prevalent endocrine cancer. Evidence showed a significant association between diet and DTC. Thus, this study aimed to assess the relationship between dietary intakes and DTC.
Methods: This case-control study was accomplished among 300 adult patients and 300 matched (age and gender) controls in Mashhad city, Iran. Dietary assessment was conducted and the relationship between dietary intakes and DTC were examined by a validated food-frequency questionnaire and logistic regression analysis, respectively.
Results: After adjusting for the confounders, a protective effect was observed for the highest tertile of low-fat dairy (OR=0.3, 95% CI=0.17-0.53, P < 0.001) and fruits' intakes (OR=0.28, 95% CI=0.15-0.52, P < 0.001) on DTC. However, the highest tertile of sugar intake was significantly related to greater DTC chance (OR=4.01, 95% CI=2.07-7.79, P < 0.001). A protective role was also found for vegetables in the second tertile of consumption (OR=0.3, 95% CI= 0. 0.17-0.54, P < 0.001) and for tea in the second and third tertiles (OR=0.2, 95% CI= 0.11-0.53, P < 0.001; OR=0.42, 95% CI=0.26-0.69, P = 0.001 respectively). However, the second and third tertiles of the roasted or fried meat consumption were significantly associated with higher DTC chance (OR=1.66, 95% CI= 1.007-2.76, P = 0.04; OR=1.92, 95% CI=1.07-3.42, P = 0.02 respectively). No significant association was detected for other dietary intakes.
Conclusions: Consumption of low fat dairy, fruits, vegetables, and tea had a protective effect on DTC; whereas, roasted or fried meat and sugar consumption was significantly associated with higher DTC chance. Further studies are needed to confirm these results.
The Relationship between Dietary Patterns and Irritable Bowel Syndrome in Adolescent Girls
Authors: Banazadeh Vahideh , Jaberi Najmeh , Hoseinkhani Fatemeh , Bagherniya Mohammad , Khayyatzadeh Sayyed Saeid , Ghayour-Mobarhan Majid
Published: May 2020

Background: Dietary factors are associated with the development of irritable bowel syndrome (IBS) in adults, but no studies have ever investigated the relationship between dietary patterns and the risk of IBS among adolescents.
Methods: In this cross-sectional study a total of 750 adolescent girls aged 12 to 18 years old were recruited using a random cluster sampling method from several schools in different areas of Mashhad city, Iran. A validated food frequency questionnaire (FFQ) and the modified version of Rome III questionnaire were administered to assess the participants' dietary intakes and IBS, respectively. Socio-demographic data and anthropometric variables were also obtained. Factor analysis was performed to identify major dietary patterns.
Results: The dietary patterns of healthy, mix, and western were identified in this study. An inverse non-significant association was also observed between the healthy dietary pattern and IBS (OR: 0.83; 95% CI: 0.47-1.48). The relationship of IBS prevalence with mix and western dietary patterns was also non-significant.
Conclusions: No statistically significant associations were found between dietary patterns and IBS among Iranian girl adolescents. Further studies, particularly longitudinal intervention studies with a larger sample size are required in this area.
Comparison of Nutrients' Intakes in Children with and without Attention Deficit Hyperactivity Disorder
Authors: Shareghfarid Elham , Sangsefidi Zohreh Sadat , Hosseinzadeh Mahdieh , Salehi-Abargouei Amin , Mohammadi Mohammad
Published: May 2020

Background: Attention deficit hyperactivity disorder (ADHD) is the most common chronic mental disorder among children. Children with ADHD may be at risk for a variety of nutrients' deficiencies. We aimed to assess the nutrients' intakes among ADHD children and compare them with the healthy ones.
Methods: This was a hospital-based case-control survey over 120 ADHD as the cases and 240 non-ADHD children as the control participants aged 6-13 years. Usual dietary intakes were assessed using a validated semi quantitative food-frequency questionnaire (FFQ). The P-values were considered significant if they were < 0·05.
Results: Energy: 2812.2 ± 1029.9 kcal/day vs. 3136.4 ± 1360.3 kcal/day, P = 0.001), fat: 78.3 ± 28.8 g/day vs. 87.2 ± 44.9 g/day, P > 0.001), and carbohydrate: 436.8 ± 192.6 g/day vs. 479.9 ± 244.2 g/day, P = 0.009) intakes were significantly lower in ADHD than healthy children. Similarly, consumption of calcium: 968.5 ± 358.3 mg/day vs. 1055.7 ± 453.4 mg/day, P = 0.03) and magnesium: 363.1 ± 173.9 mg/day vs. 411.9 ± 220.8 mg/day, P = 0.01) were significantly lower in the cases than control group. However, intakes of thiamin: 34.4±18.8 mg/day vs. 40.4 ± 25.6 mg/day, P = 0.002), riboflavin: 1.99 ± 0.76 mg/day vs. 2.21 ± 0.95 mg/day, P = 0.01), niacin: 24.9 ± 10.6 mg/day vs. 27.5 ± 13.2 mg/day, P = 0.01), and vitamin B5: 6.85 ± 3.35 mg/day vs. 7.49 ± 3.84 mg/day, P = 0.02) were significantly lower in the case than control group.
Conclusion: Children with ADHD consumed significantly lower quantities of energy, macronutrients, calcium, magnesium, B vitamins (B1, B2, B3, B5), and vitamin C compared with the healthy children.
A MODIFIED HUMAN DEVELOPMENT INDEX, DEMOCRACY AND ECONOMIC GROWTH IN INDONESIA
Authors: Leiwakabessy Erly , Amaluddin Amaluddin
Published: May 2020

Purpose of the study: Firstly, to construct a modified human development index by incorporating new dimensions (democracy and employment). Secondly, to measure and compare human development progress in Indonesian provinces. Thirdly, to examine the nexus between human development, economic growth, and democracy during the period 2010-2017.

Methodology: Principle Component Analysis (PCA) method is employed to combining components into one index (composite index) which we call MHDI. The panel simultaneous equation model is applied to examine the nexus between human development, economic growth, and democracy.

Main Findings: There were significant ranking differences between MHDI and HDI-UNDP in 24 provinces of 33 Indonesian provinces. The most significant ranking differences were found in several provinces, especially Maluku, West Java, Central Java, East Java, and Central Kalimantan. The study found a strong two-way relationship between human development and economic growth as well as between human development and democracy.

Applications of this study: This study recommends that human development policies supported by rapid economic growth and democratic stability should be one of the development priorities through government spending and support from private investment (the private sector) which focuses on the development of education and health infrastructure throughout the Indonesian province.

Novelty/Originality of this study: This study employs different methods for constructing a human development index by incorporating a new dimension (democracy and employment).
STUDY OF SOCIAL REALIZATION OF COMMUNITY PARTICIPATION ON DEVELOPMENT IN GAMPONG MERDUATI VILLAGE BANDA ACEH
Authors: Sukowati Praptining , Usman Muhammad , Made Weni I , Sadhana Kridawati
Published: May 2020

Purpose of Study: The purpose of this study is to describe and analyze community participation and the factors that influence the development of the Gampong Merduati village in Banda Aceh. The qualitative research method is the method used in this study. Determination of informants is done by purposive sampling, assuming that the informant understands the problem being studied and can provide information and responses to the issues that are the objectives of this study.

Methodology: The data needed in this study consists of primary data and secondary data. Data collection techniques are interviews, observation, and documentation studies. Data analysis in this study used the method of Milles and Hubernan (1984), which consisted of Data Reduction, Display Data, and Conclusion Drawings.

Main Findings: The results of this study show that community participation in the implementation of the Village Fund Allocation (ADD) in the Gampong Merduati Banda Aceh, both participation in the form of energy, mind, and involvement in the form of the budget has been running well, following the wishes of community members and implementation instructions. Factors affecting community participation in the implementation of the Village Fund Allocation in Gampong Merduati Village in Banda Aceh are a sense of belonging, responsibility, and habits that have become a tradition in the Gampong Merduati Village.

Applications of this study: The community, government, and universities can use the results of this study.

Novelty/Originality: The ability of human resources (HR) of community members is reliable so that it has implications for the quality and quantity of the Village Fund Allocation itself. This research recommends further research on the role of government in encouraging community involvement in development.
Problemas del embarazo relacionados con errores hereditarios de la b-oxidación mitocondrial fetal
Authors: Osorio O José Henry
Published: May 2020

Hace algún tiempo fue reportado que errores hereditarios en la oxidación de ácidos grasos en el feto, pueden predisponer a complicaciones de la madre durante el embarazo. El campo de los errores innatos del metabolismo crece permanentemente como resultado del reporte continuo de nuevas enfermedades en diferentes vías metabólicas, ayudado por el auge en investigación y tecnología desarrollado en el área. El presente trabajo, revisa la interrelación entre los errores hereditarios de la b-oxidación mitocondrial de los ácidos grasos en fetos homocigotos, o heterocigotos compuestos y el embarazo de madres heterocigotas para las mismas deficiencias.
Carcinoma ductal in situ de mama
Authors: Cortés Yepes Hernán
Published: May 2020

El carcinoma ductal in situ de mama es un grupo heterogéneo de neoplasias, el cual ha presentado un gran aumento en su incidencia en la última década, además es una enfermedad que se diagnostica en pacientes asintomáticas en su gran mayoría, gracias al uso de la mamografía como tamizaje.No hay un tratamiento único para este tipo de patologías y en algunos casos puede ser recomendable el uso de radioterapia; se sabe también que la quimioprevención juega un papel importante en el manejo.En base al índice de Van Nuys, se dan unas pautas de manejo.
Aplicaciones del ultrasonido transvaginal en medicina materno-fetal: experiencia institucional
Authors: Serrano Claudia J. , Sarmiento Andrés
Published: May 2020

Se revisa el ultrasonido transvaginal como técnica diagnóstica en el escenario obstétrico y de la medicina materno-fetal. Se comenta su utilidad clínica en el diagnóstico y seguimiento de pacientes con condiciones obstétricas específicas. A la luz de la evidencia científica actual, se comentan los resultados de estudios de investigación llevados a cabo en nuestro Hospital acerca del valor clínico de esta arma diagnóstica.
Editorial
Authors: Gaitán Duarte Hernando , Lomanto Morán Antonio
Published: May 2020

Señores lectores de la Revista Colombiana de Obstetricia y Ginecología.Al posesionarnos hace ya tres años de la dirección de la revista consideramos que nuestro principal objetivo era colocar la revista en los niveles internacionales de excelencia en materia de publicaciones científicas.Basados en el hecho de que el momento actual es una circunstancia especial debido al auge que ha tomado la Medicina Basada en la Evidencia, que muchas veces puede provenir de revistas extranjeras, pero que también debe provenir de investigación propia ya que nuestros problemas en salud pueden ser diferentes, pues son nuestras pacientes las que presentan en su mayoría la patología. Tal es el caso de la mortalidad materna, tragedia que ocurre especialmente en los países en desarrollo, o de la toxemia, donde la eclampsia es considerada en los países desarrollados como un indicador de mala calidad de atención y en nuestro país es un problema de salud pública.
Manejo del dengue hemorrágico durante el embarazo y presentación de dos casos
Authors: Acosta Osio Guillermo , Acosta Osio Juan José , Bittar Amaury , Carmona Ruth , Cervantes Astrid
Published: May 2020

Se presentan dos casos de dengue hemorrágico durante el embarazo, manejados en el Hospital Universitario Metropolitano, el primero con 35 semanas y el segundo con 21 semanas. Comprobándose el diagnóstico de ambos no sólo por el cuadro clínico, sino también por la prueba del torniquete y la positividad de las inmunoglobulinas.Anotamos que no encontramos documentación sobre pacientes con dengue hemorrágico y embarazo sin otra complicación, por lo tanto presentamos y sugerimos el manejo que realizamos, pues fue satisfactorio en las dos pacientes.Consideramos de suma importancia la divulgación de estos casos, ya que son muy escasos los reportes en la literatura sobre dengue y embarazo, y no existe un manejo estipulado para estas pacientes, a pesar de haber revisado las normas de la Organización Panamericana de la Salud (OPS).
Some personal and professional variables as identifiers of teachers’ lifelong learning tendencies and professional burnout
Authors: Yildiz Durak Hatice , Seferoglu Suleyman Sadi , Sen Nihal
Published: May 2020

In this study, it is aimed to determine teachers’ lifelong learning (LLL) tendencies. It is also aimed to reveal the variables that are associated to the LLL tendencies and to predict its levels. This research, which was a relational model, was utilised in spring term of 2017–2018 academic year. The participants of the study consisted of 199 teachers working at various school levels associated with the Ministry of National Education. According to the results of the study, it was found that demographic, occupational variables and the burnout in the multiple linear regression analysis were significant predictors of LLL tendency. When the variables are considered one by one, it is concluded that the predictors of teachers’ LLL tendencies are age, occupational seniority and burnout.
Keywords: Teachers, lifelong learning tendency, personal variables, occupational variables, occupational burnout
High school students’ higher education expectation: A scale development study
Authors: Cetin Yavuz , Dincer Beste
Published: May 2020

The aim of this study is to develop a valid and a reliable scale to determine the expectations of high school students from higher education. The population of the study consisted of 315 high school students in the 2018–2019 academic years. To test the construct validity of the scale, exploratory factor analysis and confirmatory factor analysis were used. The original five-point Likert scale composed of 22 items with five subdimensions. The results showed that the internal consistency coefficient of the scale was calculated as 0.84. The scale factor load values ranged between 0.58 and 0.81, and the rotated factor load values ranged between 0.46 and 0.81 and explained 59.1% of the total variance of the scale. The higher education expectation scale can be used not only to evaluate the students’ future and professional expectations in terms of subjective norms but also goal setting and need for the analysis of the program development studies.
Keywords: High school students, expectation, scale development
Tantangan Media Massa Dalam Menghadapi Era Disrupsi Teknologi Informasi
Authors: Putra Reza Ade
Published: May 2020

Media massa atau pers, merupakan alat atau sarana penyampaian informasi kepada masyarakat luas melalui media massa seperti media cetak maupun elektronik. Media massa dapat dibagi atas tiga jenis, yaitu media elektronik seperti televisi dan radio, media cetak yaitu koran dan majalah dan terakhir yaitu media online seperti internet, streaming TV dan informasi yang dapat diakses melalui internet. Jumlah pengguna internet yang begitu cepat bertambah ini menjadi semakin meningkat seiring dengan berkembangnya variasi media komunikasi berbasis internet. Pemanfaatannya yang begitu mudah dan dapat diakses dimana saja menjadi pilihan bagi sebagian besar masyarakat. Media cetak pun nyaris tersingkir dengan kehadiran media online. Menyikapi kemungkinan tersebut, maka industri media massa di Indonesia dituntut untuk menyesuaikan dirinya pada era globalisasi berbasis teknologi digital pada saat ini. Salah satu solusi yang diambil adalah digitalisasi koran dalam bentuk e-paper guna menjangkau pembaca yang lebih luas.
Sistem Informasi Penyedia Layanan Kursus di Kota Palembang
Authors: Kurniawan Fandi , Ruliansyah Ruliansyah , Kadafi Muhamad
Published: May 2020

Dewasa ini, teknologi berkembang cepat. Trend terbarui, beberapa perusahaan menggunakan aplikasi berbasis internet untuk mendukung pemasaran produknya. Tidak hanya pada kegiatan promosi yang menampilkan produk supaya diketahui oleh para konsumennya, bahkan beberapa perusahaan menggunakan teknologi internet ini untuk mendukung kegiatan transaksi, misalnya penjualan produk kepada konsumennya. Penelitian ini bertujuan untuk merancang dan membangun Sistem Informasi Penyedia Layanan Kursus di Kota Palembang mengingat banyaknya lembaga kursus dan susahnya mencari lembaga kursus secara cepat, dan terpercaya di kota Palembang. Metode penelitian yang digunakan yaitu metode penelitian kualitatif dengan metode pengumpulan data yaitu observasi, wawancara, studi pustaka. Metode pengembangan sistem yang digunakan yaitu Prototype. Alat bantu analisis dan perancangan yang digunakan yaitu Unified Modeling Language (UML), Bahasa pemrograman yang digunakan yaitu Hypertext Preprocessor (PHP), framework Codeigniter, serta database menggunakan MySQL, Metode pengujian menggunakan Graphical User Interface (GUI). Diharapkan sistem menjadi mesin pencari kursus di Kota Palembang.
Implementasi Metode Profile Matching Dalam Aplikasi Penerimaan Siswa Baru pada SMK Ma’arif NU 2 Boyolali
Authors: Prabowo Mei , Suprapto Agung
Published: May 2020

Selama ini proses penerimaan siswa baru pada SMK Ma’arif NU 2 Boyolali sudah berbasis online, akan tetapi dalam melakukan perangkingan serta menentukan calon siswa tersebut lulus atau tidak masih bersifat manual, sehingga belum optimal. Oleh karena itu dalam mengoptimalkan proses tersebut, maka di sisipkanlah sistem pendukung keputusan pada sistem informasi yang sudah ada pada SMK NU Ma’arif 2 Boyolali. Tujuan dari penelitian ini adalah merancang serta membuat sistem pendukung keputusan penerimaan siswa baru dengan menggunakan metode Profile Matching yang terintegrasi langsung dengan sistem yang sudah berjalan. Metode yang digunakan dalam pengembangan sistem ini adalah Rapid Application Development. Hasil akhir dari penelitian ini adalah perangkingan data calon siswa baru yang mendaftar pada SMK Ma’arif NU 2 Boyolali yang diseleksi berdasarkan kriteria- kriteria yang sudah ditentukan. Keluaran dari aplikasi ini secara real time akan tampil di sistem dan dapat untuk membantu dalam pengambilan keputusan dalam menerima siswa baru.
Analisis Kepuasan Pengguna Sistem Keagenan PERISAI Menggunakan End User Computing Satisfaction (Studi Kasus: BPJS Ketenagakerjaan Kantor Cabang Palembang)
Authors: Pranita Masdalia Julya , Zulfikar Dian Hafidh , Gunawan Catur Eri
Published: May 2020

Penelitian ini ditujukan untuk mengetahui kepuasan pengguna Sistem Keagenan Perisai BPJS Ketenagakerjaan Kantor Cabang Palembang. BPJS Ketenagakerjaan meluncurkan Penggerak Jaminan Sosial Indonesia (PERISAI) yang merupakan sebuah inovasi dari BPJS Ketenagakerjaan untuk memperluas cakupan kepesertaan dan perlindungan jaminan sosial ketenagakerjaan melalui sistem keagenan untuk mengakuisisi pekerja informal atau Bukan Penerima Upah (BPU) dan Usaha Mikro Kecil Menengah (UMKM). Dan dalam penelitian ini digunakan Model End User Computing Satisfaction, dimana dalam mengukur Sistem Keagenan Perisai BPJS Ketenagakerjaan Kantor Cabang Palembang Model End User Computing Satisfaction terdiri dari 5 faktor yaitu Isi (Content), Akurasi (Accuracy), Bentuk (Format), Kemudahan Pengguna (Ease to Use), dan Ketepatan Waktu (Timeliness) sebagai variabel independen dan kepuasan sebagai variabel dependen. Data yang dikumpulkan dengan menggunakan kuesioner yang disebarkan, Hasil dari penelitian ini adalah tingkat kepuasan pengguna sistem keagenan perisai sebesar 24,5% merasa sangat setuju, 58,0%  merasa setuju, 14,0%  merasa cukup, 3,5% merasa tidak  setuju, dan 0,1% merasa sangat tidak setuju. Dari hasil penelitian ini dapat dijadikan sebagai masukan atau rekomendasi kepada pihak pengelola Sistem Keagenan Perisai BPJS Ketenagakerjaan Kantor Cabang Palembang dalam memperbaiki dan meningkatkan kepuasan pengguna.
A EDUCAÇÃO ESPECIAL E O ATENDIMENTO EDUCACIONAL ESPECIALIZADO NO ENSINO SUPERIOR DE MÚSICA: UM RECORTE SOBRE QUATRO UNIVERSIDADES DO ESTADO DO RIO GRANDE DO SUL
Authors: Valim Mariana , Pacheco Eduardo Guedes
Published: May 2020

A Política Brasileira de Educação Especial tem sido feita, nos últimos anos, por movimentos e legislação que buscam organizar e regulamentar o acesso, a permanência, aprendizagem e recursos de atendimento pedagógico para o aluno com Necessidades Especiais. Esta pesquisa visou  investigar estas regulamentações nos cursos de Licenciatura em Música, ao analisar quatro instituições de Ensino Superior no Rio Grande do Sul, para conhecer a acessibilidade da Pessoa com Deficiência ao Ensino Superior de Música. Relata e analisa como estas Instituições prevêem em seus regulamentos e como implementam, na prática, as condições de permanência com qualidade e garantia de acesso ao processo educativo e formativo do aluno PCD.
TIMBRE Y SIGNIFICACIÓN POR UNA SEMIOLOGÍA DE LAS FORMAS SONORO-SIMBÓLICAS
Authors: Sad Jorge
Published: May 2020

En este artículo nos proponemos investigar las condiciones de posibilidad de una semiología de las “ formas sonoro simbólicas”  a partir de una utilización crítica del marco metodológico concebido por Jean Molino y Jean-Jacques Nattiez ( de ahora en más M/N) para la semiología musical - el de la semiología tripartita-, incluyendo la música dentro de un cuadro más extenso, junto a las otras ¨artes del sonido”.
FOLCLORE MUSICAL EM FAMÍLIA: PRÁTICAS E CONCEPÇÕES DE ESTUDANTES E SEUS FAMILIARES
Authors: Wolffenbüttel Cristina Rolim , Felicio Graziela da Rosa Silva , Grezeli Estêvão , Chaves Fabiane Araújo , Parnoff Alex
Published: May 2020

A prática dos cantos, particularmente das cantigas de ninar, tem sido investigada ao longo dos anos. Considerando-se a importância inerente ao canto e a relação que se estabelece na família, este artigo apresenta os resultados da pesquisa que teve por objetivo verificar a importância do estímulo familiar da música folclórica na infância, através da prática dos acalantos, e as diversas interações estabelecidas em suas memórias afetivas, tanto nas crianças que ouviam quanto nos adultos que as cantavam. A metodologia teve como desenho a abordagem qualitativa e a aplicação de formulários com alunos de 11 a 16 anos de idade, em uma escola de ensino fundamental de Capão da Canoa/RS, estendido aos seus responsáveis, como técnica para a coleta dos dados. O referencial teórico é fundamentado nos conceitos de folclore, apresentado como cultura advinda das pessoas e passada de geração em geração. Como resultados desta investigação observou-se que, mesmo vivenciadas, tanto os familiares quanto os estudantes, as práticas de entoar cantigas de ninar sofrem dificuldades quanto ao reconhecimento de sua prática, numa perspectiva cultural e inserida nas vivências das pessoas. Dentre as perspectivas citadas foi possível destacar a forma percebida pelos entrevistados sobre o tema levantado e realizar apontamentos para uma reflexão ainda maior sobre o papel da escola dentro de sua comunidade como ponto de referência cultural.
A MÚSICA COMO INSPIRAÇÃO POÉTICA PARA A CRIAÇÃO: RELATOS SOBRE A MONTAGEM DO ESPETÁCULO “DANÇAR AS COISAS DO PAGO”
Authors: Barboza Mônica Corrêa de Borba , Alves Mara Rubia , Grecco Afonso Machado
Published: May 2020

Neste relato enfatizamos o papel da Música na montagem da obra “Dançar as coisas do pago”, projeto de extensão realizado em 2018, na Universidade Federal de Santa Maria. Partimos da utilização de canções como inspirações/perguntas condutoras dos procedimentos de criação. Em torno de 28 artistas com diversos corpos (com e sem deficiências, faixas etárias diversas e experiências distintas em/com Dança) integraram o elenco. Destacamos a importância que a experiência teve na formação dos futuros professores e professoras envolvidas. Também ressaltamos o quanto o repertório musical escolhido trouxe elementos para acessar memórias e o imaginário de cada um, favorecendo a criação e sobretudo a expressividade e a autoria dos bailarinos.
ESPECIFICIDADES E TRAJETÓRIAS FORMATIVAS – UMA REVISÃO DE LITERATURA
Authors: Soares Isac Costa
Published: May 2020

Este artigo trata da revisão bibliográfica utilizada em minha pesquisa inicial no mestrado em educação musical da UFRGS, que tem como objetivo compreender as trajetórias formativas de trompetistas atuantes no cenário musical de Porto Alegre. Neste caso, a revisão de literatura contribuiu para uma visão mais aprofundada sobre esse assunto trazendo trabalhos que convergem com o tema proposto. Aqui trago dissertações, teses e artigos que me ajudaram a definir e delimitar meu tema de pesquisa com mais precisão.
Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo
Authors: Vinton Carol L. , Starke Carly E. , Ortiz Alexandra M. , Lai Stephen H. , Flynn Jacob K. , Sortino Ornella , Knox Kenneth , Sereti Irini , Brenchley Jason
Published: May 2020

AbstractBackground: Microbial translocation occurs after damage to the structural and/or immunological barrier of the gastrointestinal (GI) tract into circulation. Microbial components that translocate from the lumen of the GI tract directly stimulate the immune system and contribute to inflammation. When microbial translocation becomes chronic, the inflammation has detrimental consequences. Given that microbial translocation is an important phenomenon in many diseases, defining biomarkers that reliably reflect microbial translocation is critical. Measurement of systemic microbial products is difficult since: 1) robust assays to measure microbial antigens simultaneously are lacking; 2) confounding factors influence assays used to detect microbial products; and 3) biological clearance mechanisms limit their detection in circulation. Thus, host proteins produced in response to microbial stimulation are used as surrogates for microbial translocation; however, many of these proteins are also produced in response to host proteins expressed by dying cells.Methods: We measured plasma levels of biomarkers associated with GI tract damage, immune responses to microbial products, and cell-death in people living with HIV before and after antiretroviral administration, and in macaque nonhuman primates before and after SIV infection.Results: Proteins secreted during cellular stress (receptor for advanced glycation endproducts - RAGE and high motility group box 1 -HMGB1), which can induce sCD14 production in vitro and in vivo, do not associate with elevated levels of biomarkers associated with microbial translocation in progressively HIV-infected individuals and SIV-infected NHPs. Conclusions: Bystander cell death and generalized inflammation do not contribute to elevated levels of sCD14 observed in HIV/SIV-infected individuals.
Le point sur la lipolyse du lait de vache : facteurs de variation et mécanismes biochimiques
Authors: VANBERGUE Élise , POULET Jean-Louis , PEYRAUD Jean-Louis , HURTAUD Catherine
Published: May 2020

La lipolyse est une réaction enzymatique qui influence négativement les qualités organoleptiques et technologiques du lait. Dans certaines régions de France, la lipolyse est un critère de paiement du lait. La susceptibilité des vaches à la lipolyse conditionne les fluctuations de la lipolyse dans le tank. Les vaches dites « non susceptibles » présentent un taux de lipolyse individuel faible et stable pendant leur carrière alors que les vaches dites « susceptibles » présentent un taux de lipolyse fluctuant de faible à très élevé, en fonction des facteurs d’élevage, de l’installation de traite et du stockage. Selon les systèmes d’élevage, plusieurs leviers sont disponibles pour minimiser la lipolyse : sélection de vaches « non susceptibles » à la lipolyse parmi les vaches Holstein ou recours à d’autres races de vaches moins « susceptibles » telles que les vaches de race Normande ou Tarentaise à titre d’exemple, tarissement à 6 mois de gestation pour les vaches « susceptibles », maintien de la fréquence de traite à deux traites par jour. Une attention particulière doit être accordée à l’équilibre des rations (énergie, azote) et à la complémentation (lipides) surtout chez les vaches fortes productrices en début de lactation. Le pâturage semble être associé à des niveaux de lipolyse faibles. Un bon entretien des installations de traite doit être réalisé car la présence de dysfonctionnements multiplie l’impact du circuit de traite sur la lipolyse. Avec les robots de traite, la lipolyse est en moyenne plus élevée qu’en traite conventionnelle, cependant l’amélioration des matériels est continue. Les mécanismes biochimiques, explicatifs de la lipolyse sont toujours à l’étude.)
How does the ICT Access and Usage Influence Student Achievement in PISA 2009 and 2012?
Authors: YURTTAŞ KUMLU Gülfem Dilek , DOĞAN Nuri
Published: May 2020

The purpose of this study is to investigate the effects of access and usage of information and communication technologies (ICT) on Turkish students’ mathematics achievement implemented in PISA 2009 and PISA 2012. A correlational research model was used in this study. In this study, the data which were obtained from the PISA 2009 and PISA 2012 mathematics achievement tests and from the information and communications technologies familiarity questionnaire (ICTFQ) in Turkey were used. In this study, three student level variables and two school variables of ICTFQ which are common indexes both in PISA 2009 and PISA 2012 were selected to compare the effect of ICT variables on PISA mathematics achievement implemented in different years. Two-level Hierarchical Linear Modeling (HLM) analysis was performed in the analysis of the data. As a result, the student level variables had a small or a trivial effect on mathematics achievement. The effect size value of the ENTUSE variable was similar in the PISA 2009 and the PISA 2012 implementation, but the effect size value of the HOMSCH variable and the ICTHOME variable on mathematics achievement in PISA 2012 was lower than in PISA 2009. The ICTSCH and the USESCH variables at the school level had a large effect on mathematics achievement in two implementations of PISA 2009 and PISA 2012. The effect size value of the ICTSCH variable on mathematics achievement in PISA 2012 was higher than in PISA 2009. The effect size value of the ICTSCH variable, having a negative relationship with mathematics achievement in PISA 2012, was lower than in PISA 2009. In this study, the explained variance ratio of mathematics achievement by the school ICT variables level was greater than by the student ICT variables level.