bluuebunny/crossref_metadata_2025 huggingface dataset:
In-situ carbonization of ZIF-67 to fabricate magnetically Co/N-mC with high adsorption capacity toward water remediation
Authors: Zheng Zihao , Liu Qiye , Wang Fangxiao
Published: January 2021

Co and N co-modified mesoporous carbon composites (Co/N-mC) have been simply prepared at low cost from the carbonization of ZIF-67 wherein not only providing surface N-modification for promoting the adsorption behavior of acidic dyes, but also constructing a magnetic property for convenient separation. Co/N-mC composite presented the adsorption ability of MO (178 mg g−1) > RhB (141 mg g−1) (T = 25 °C, pH = 7.0, C0 = 20 mg L−1) because of its spacious porous structure (BET: 250.8 m2 g−1; pore size: 3.9 nm) and functional basic character (pyrrolic-N and pyridinic-N). Compared with basic dyes (RhB), mesoporous C doped with N improves the adsorption of acid dyes (MO). In addition, the magnetic properties introduced in the Co/N-mC make it easier to separate after adsorption and regeneration by an external magnetic field.
Effects of hyperbaric oxygen therapy on vascular endothelial growth factor protein and mRNA in crush injury patients: A randomized controlled trial study
Authors: Oley Mendy Hatibie , Oley Maximillian Christian , Noersasongko Albertus Djarot , Hatta Mochammad , Philips Gerard G. , Agustine  , Faruk Muhammad , Kalangi Jane Angela , Rumampuk Irene M.A. , Tulong Marcella Tirza
Published: January 2021

ABSTRACT

Introduction:

Limb injury is a major health concern that imposes a direct danger to both life and limb viability. At Kandou Hospital Manado, hyperbaric oxygen (HBO) therapy has been performed as an adjunctive treatment for crush injury although no study has yet directly compared outcomes of HBO versus conventional therapy. Documentation of the association between HBO therapy and the healing process of crush injury is necessary to reduce the gaps in the literature and to establish an evidence-based clinical use of HBO therapy.

Methods:

In this study, we assessed the changes in the vascular endothelial growth factor (VEGF) serum levels and VEGF mRNA expression as biomarkers of wound healing using ELISA and qRT-PC at four different measurement times: at baseline, after receiving initial treatment (debridement and limb-salvage surgeries), 2 h after the first session HBOT, and after a full 10 HBOT sessions. A randomized controlled trial (RCT) was used to enroll patients subjected to crush injury who were admitted to the Surgical Emergency Department (ER) of Kandou Hospital Manado, Indonesia.

Results:

VEGF serum levels increased significantly in patients suffering from crush injury who received HBO therapy versus the control group. The increased VEGF serum is expected to result in an acceleration time of wound healing and a reduction in amputation rate.

Conclusion:

There was a significant difference between crush injury patients who received conservative therapy versus those receiving HBO therapies; thus, there was an increased likelihood of an accelerated wound healing and a reduction in the risk of amputation.

Highlights
Tumor Epigenetic Signature and Survival in Resected Gastric Cancer Patients
Authors: Woo Yanghee , Behrendt Carolyn E. , Yang Annie , Hahn Maria , Goel Ajay , Li Haiqing , Yuan Yate-Ching , Fong Yuman
Published: January 2021

BACKGROUND:

Precision oncology can identify patient-specific molecular signatures to better inform the prognosis and management of surgical cancer patients. Specifically, microRNAs (miRs) hold promise as prognostic biomarkers because dysregulation of individual miRs is implicated in tumorigenesis, progression, and metastases of various malignancies, including gastric adenocarcinoma (GC).

STUDY DESIGN:

To identify miRs prognostic of survival after radical gastrectomy, we studied GC patients within The Cancer Genome Atlas (TCGA) who had undergone R0 or R1 resection and had data on clinical characteristics, overall survival (OS), and tumor miR expression. The miRs expressed by at least 15% of tumors were eligible for study. From 10 replicate samples, each with 80% of patients, miRs were selected using age-adjusted proportional hazards regression with stepwise selection. Cross-validated miRs (selected by multiple replicates) were retained if they optimized an accelerated failure-time model of OS using all patients.

RESULTS:

In this GC cohort (n = 270), half (916/1,870) of miRs screened met our criteria for evaluation. Cross-validation identified 20 miRs as prognostic, of which 14 (miR-129-1, miR-373, miR-490, miR-597, miR-1185-2, miR-3943, miR-4756, miR-5683, miR-6510, miR-6733, miR-6808, miR-6855, miR-6882, miR-8072) were independently informative. The age-adjusted 14-miRNA panel remained significantly associated with OS after adjustment for pathologic prognostic factors (number of lymph nodes examined, number of positive lymph nodes) and other clinical covariates (TNM stage, residual tumor, tumor microsatellite instability, targeted molecular therapy, sex, race, ethnicity). Panel-predicted survival estimates below the upper tertile cut-off were associated with worse outcome (30% vs 74% OS at 3 years, p < 0.0001).

CONCLUSIONS:

In surgically resected GC patients, an epigenetic signature of miRs associated with survival has the potential to improve prognostication.
Reading Computer-Generated Texts
Authors: Henrickson Leah
Published: January 2021

Natural language generation (NLG) is the process wherein computers produce output in readable human languages. Such output takes many forms, including news articles, sports reports, prose fiction, and poetry. These computer-generated texts are often indistinguishable from human-written texts, and they are increasingly prevalent. NLG is here, and it is everywhere. However, readers are often unaware that what they are reading has been computer-generated. This Element considers how NLG conforms to and confronts traditional understandings of authorship and what it means to be a reader. It argues that conventional conceptions of authorship, as well as of reader responsibility, change in instances of NLG. What is the social value of a computer-generated text? What does NLG mean for modern writing, publishing, and reading practices? Can an NLG system be considered an author? This Element explores such question, while presenting a theoretical basis for future studies.
Global Britain's strategic problem East of Suez
Authors: James William D.
Published: January 2021

Why did Britain withdraw from its military bases in the Arabian Peninsula and Southeast Asia midway through the Cold War? Existing accounts tend to focus on Britain's weak economic position, as well as the domestic political incentives of retrenchment for the ruling Labour Party. This article offers an alternative explanation: the strategic rationale for retaining a permanent presence East of Suez dissolved during the 1960s, as policymakers realised that these military bases were consuming more security than they could generate. These findings have resonance for British officials charting a return East of Suez today under the banner of ‘Global Britain’.
Non-existence of sublinear diffusion for a class of torus homeomorphisms
Authors: SILVA SALOMÃO GUILHERME , TAL FABIO ARMANDO
Published: January 2021

We prove that, if f is a homeomorphism of the 2-torus isotopic to the identity whose rotation set is a non-degenerate segment and f has a periodic point, then it has uniformly bounded deviations in the direction perpendicular to the segment.
Infectivity of healthcare workers diagnosed with coronavirus disease 2019 (COVID-19) approximately 2 weeks after onset of symptoms: A cross-sectional study
Authors: Longtin Yves , Charest Hugues , Quach Caroline , Savard Patrice , Baz Mariana , Boivin Guy , Farfard Judith , Villeneuve Jasmin , Roger Michel , De Serres Gaston
Published: January 2021

We performed viral culture of respiratory specimens in 118 severe acute respiratory coronavirus virus 2 (SARS-CoV-2)–infected healthcare workers (HCWs), ∼2 weeks after symptom onset. Only 1 HCW (0.8%) had a positive culture. No factors for prolonged viral shedding were identified. Infectivity is resolved in nearly all HCWs ∼2 weeks after symptom onset.
Risk factors for mortality and progression to severe COVID-19 disease in the Southeast region in the United States: A report from the SEUS Study Group
Authors: Hobbs Athena L. V. , Turner Nicholas , Omer Imad , Walker Morgan K. , Beaulieu Ronald M. , Sheikh Muhammad , Spires S. Shaefer , Fiske Christina T. , Dare Ryan , Goorha Salil , Thapa Priyenka , Gnann John , Wright Jeffrey , Nelson George E.
Published: January 2021

Objective:

Identify risk factors that could increase progression to severe disease and mortality in hospitalized SARS-CoV-2 patients in the Southeast region of the United States.

Design, setting, and participants:

Multicenter, retrospective cohort including 502 adults hospitalized with laboratory-confirmed COVID-19 between March 1, 2020, and May 8, 2020 within 1 of 15 participating hospitals in 5 health systems across 5 states in the Southeast United States.

Methods:

The study objectives were to identify risk factors that could increase progression to hospital mortality and severe disease (defined as a composite of intensive care unit admission or requirement of mechanical ventilation) in hospitalized SARS-CoV-2 patients in the Southeast United States.

Results:

In total, 502 patients were included, and 476 of 502 (95%) had clinically evaluable outcomes. The hospital mortality rate was 16% (76 of 476); 35% (177 of 502) required ICU admission and 18% (91 of 502) required mechanical ventilation. By both univariate and adjusted multivariate analyses, hospital mortality was independently associated with age (adjusted odds ratio [aOR], 2.03 for each decade increase; 95% confidence interval [CI], 1.56-–2.69), male sex (aOR, 2.44; 95% CI, 1.34–4.59), and cardiovascular disease (aOR, 2.16; 95% CI, 1.15–4.09). As with mortality, risk of severe disease was independently associated with age (aOR, 1.17 for each decade increase; 95% CI, 1.00–1.37), male sex (aOR, 2.34; 95% CI, 1.54–3.60), and cardiovascular disease (aOR, 1.77; 95% CI, 1.09–2.85).

Conclusions:

In an adjusted multivariate analysis, advanced age, male sex, and cardiovascular disease increased risk of severe disease and mortality in patients with COVID-19 in the Southeast United States. In-hospital mortality risk doubled with each subsequent decade of life.
Concerns regarding Covid-19 vaccine certificates
Authors: Spisak Brian R. , McNulty Eric J.
Published: January 2021

Besides vaccine certificates, research suggests leaders also need to trigger society’s intrinsic motivation to help in order to achieve lasting and equitable solutions.
A NEW ALGORITHM FOR DECOMPOSING MODULAR TENSOR PRODUCTS
Authors: BARRY MICHAEL J. J.
Published: January 2021

Let p be a prime and let

$J_r$
denote a full

$r \times r$
Jordan block matrix with eigenvalue

$1$
over a field F of characteristic p. For positive integers r and s with

$r \leq s$
, the Jordan canonical form of the

$r s \times r s$
matrix

$J_{r} \otimes J_{s}$
has the form

$J_{\lambda _1} \oplus J_{\lambda _2} \oplus \cdots \oplus J_{\lambda _{r}}$
. This decomposition determines a partition

$\lambda (r,s,p)=(\lambda _1,\lambda _2,\ldots , \lambda _{r})$
of

$r s$
. Let

$n_1, \ldots , n_k$
be the multiplicities of the distinct parts of the partition and set

$c(r,s,p)=(n_1,\ldots ,n_k)$
. Then

$c(r,s,p)$
is a composition of r. We present a new bottom-up algorithm for computing

$c(r,s,p)$
and

$\lambda (r,s,p)$
directly from the base-p expansions for r and s.
THE DIAMETER AND RADIUS OF RADIALLY MAXIMAL GRAPHS
Authors: QIAO PU , ZHAN XINGZHI
Published: January 2021

A graph is called radially maximal if it is not complete and the addition of any new edge decreases its radius. Harary and Thomassen [‘Anticritical graphs’, Math. Proc. Cambridge Philos. Soc.79(1) (1976), 11–18] proved that the radius r and diameter d of any radially maximal graph satisfy
$r\le d\le 2r-2.$
Dutton et al. [‘Changing and unchanging of the radius of a graph’, Linear Algebra Appl.217 (1995), 67–82] rediscovered this result with a different proof and conjectured that the converse is true, that is, if r and d are positive integers satisfying

$r\le d\le 2r-2,$
then there exists a radially maximal graph with radius r and diameter

$d.$
We prove this conjecture and a little more.
Human–environment interactions at a short-lived Arctic mine and the long-term response of the local tundra vegetation
Authors: Kruse Frigga , Nobles Gary R. , de Jong Martha , van Bodegom Rosanne M. K. , van Oortmerssen G. J. M. (Gert) , Kooistra Jildou , van den Berg Mathilde , Küchelmann Hans Christian , Schepers Mans , Leusink Elisabeth H. P. , Cornelder Bardo A. , Kruijer J. D. (Hans) , Dee Michael W.
Published: January 2021

Arctic mining has a bad reputation because the extractive industry is often responsible for a suite of environmental problems. Yet, few studies explore the gap between untouched tundra and messy megaproject from a historical perspective. Our paper focuses on Advent City as a case study of the emergence of coal mining in Svalbard (Norway) coupled with the onset of mining-related environmental change. After short but intensive human activity (1904–1908), the ecosystem had a century to respond, and we observe a lasting impact on the flora in particular. With interdisciplinary contributions from historical archaeology, archaeozoology, archaeobotany and botany, supplemented by stable isotope analysis, we examine 1) which human activities initially asserted pressure on the Arctic environment, 2) whether the miners at Advent City were “eco-conscious,” for example whether they showed concern for the environment and 3) how the local ecosystem reacted after mine closure and site abandonment. Among the remains of typical mining infrastructure, we prioritised localities that revealed the subtleties of long-term anthropogenic impact. Significant pressure resulted from landscape modifications, the import of non-native animals and plants, hunting and fowling, and the indiscriminate disposal of waste material. Where it was possible to identify individual inhabitants, these shared an economic attitude ofwaste not, want not, but they did not hold the environment in high regard. Ground clearances, animal dung and waste dumps continue to have an effect after a hundred years. The anthropogenic interference with the fell field led to habitat creation, especially for vascular plants. The vegetation cover and biodiversity were high, but we recorded no exotic or threatened plant species. Impacted localities generally showed a reduction of the natural patchiness of plant communities, and highly eutrophic conditions were unsuitable for liverworts and lichens. Supplementary isotopic analysis of animal bones added data to the marine reservoir offset in Svalbard underlining the far-reaching potential of our multi-proxy approach. We conclude that although damaging human–environment interactions formerly took place at Advent City, these were limited and primarily left the visual impact of the ruins. The fell field is such a dynamic area that the subtle anthropogenic effects on the local tundra may soon be lost. The fauna and flora may not recover to what they were before the miners arrived, but they will continue to respond to new post-industrial circumstances.
Between exploration and tourism: Carl Irminger’s Iceland travel diary 1826
Authors: Lisberg Jensen Ebba , Lisberg Jensen Ole
Published: January 2021

In the spring of 1826, the young Danish naval officer Carl Irminger and two of his friends sailed with a cargo ship from Copenhagen to Iceland to stay there during the summer. This article is based on Irminger’s unpublished travel diary. Irminger and his friends blended in with the local elite, which provided them with equipment and contacts to travel. Their journeys out from Reykjavik were adventurous and depended on local guides and the hospitality of residents along the way. The tales of hardships during the travels, combined with contacts established during the trip, became important credentials in Irminger’s future career. He was hired as an adjutant to the Danish prince, and the narrative of his summer in Iceland ignited a royal expedition there in 1834, of which Irminger was to be the trip leader. Irminger’s diary reflects a broader shift from Enlightenment exploration reporting into Romantic travel writing, with more emotional and aesthetic emphasis. His journey was a forerunner of the nature tourism that eventually was to sprout in Iceland.
The branded product and the funded project: the impact of economic rationality on the practices and pedagogy of music education in the early childhood sector
Authors: Young Susan
Published: January 2021

In this article, I explore how neoliberal economic discourses and techniques have profoundly influenced the way that music education in early childhood has developed in recent years in the UK. I focus on two dominant models of practice that have been shaped by market thinking; the private music session (the ‘branded product’) and short term, stand-alone projects funded by charitable organisations (the ‘funded project’). The prevalence of these two models has resulted in highly fragmented and unequal provision accompanied by narrow conceptions of music in early childhood that give rise to impoverished practice. While I base my discussion on the early childhood sector in the UK, this discussion can nevertheless warn music educators beyond this one sector and one location of the negative consequences of abandoning music education to market forces.
LEAST SQUARES ESTIMATION FOR NONLINEAR REGRESSION MODELS WITH HETEROSCEDASTICITY
Authors: Wang Qiying
Published: January 2021

This paper develops an asymptotic theory of nonlinear least squares estimation by establishing a new framework that can be easily applied to various nonlinear regression models with heteroscedasticity. As an illustration, we explore an application of the framework to nonlinear regression models with nonstationarity and heteroscedasticity. In addition to these main results, this paper provides a maximum inequality for a class of martingales, which is of interest in its own right.
Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty
Authors: Perry Nicole B. , DePasquale Carrie E. , Donzella Bonny , Gunnar Megan R.
Published: January 2021

Megan Gunnar's pubertal stress recalibration hypothesis was supported in a recent study of previously institutionalized (PI) youth such that increases in pubertal stage were associated with increases in cortisol stress reactivity. This work provides evidence that puberty may open up a window of recalibration for PI youth, resulting in a shift from a blunted to a more typical cortisol stress response. Using the same sample (N = 132), the current study aimed to elucidate whether increases in cortisol are associated with increases in adaptive functioning or whether they further underlie potential links to developmental psychopathology. Specifically, we examined the bidirectional associations between cortisol stress reactivity and both internalizing and externalizing symptoms across three timepoints during the pubertal period. Youth reported on their own internalizing symptoms and parents reported on youths’ externalizing symptoms. Cortisol reactivity was assessed during the Trier social stress test. Analyses revealed no associations between cortisol reactivity and externalizing symptoms across puberty for PI youth. However, longitudinal bidirectional associations did emerge for internalizing symptoms such that increases in cortisol reactivity predicted increases in internalizing symptoms and increases in internalizing symptoms predicted increases in cortisol reactivity. Findings suggest that recalibrating to more normative levels of cortisol reactivity may not always be associated with adaptive outcomes for PI youth.
Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning
Authors: Lupien Sonia J. , Roy Denis-Claude , Raymond Catherine , Leclaire Sarah , Wan Nathalie , Labelle Réal , Giguère Charles-Édouard , Ouellet-Morin Isabelle
Published: January 2021

Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with mental illness. Contrary to mental illness, many physical disorders such as cancer may be less stigmatized (expect pulmonary cancer). In this study, we measured externalized and internalized stigma, as well as psychological (depressive symptoms and stressful life events) and physiological (basal salivary cortisol levels) markers of stress in 115 spouses and 154 children of parents suffering from major depressive disorder, cancer, or no illness (control group). The results show that spouses and children from families with parental depression present significantly more externalized stigma than spouses and children from families with parental cancer or no illness, although we find no group differences on internalized stigma. The analysis did not show a significant group difference either for spouses or their children on depressive symptomatology, although spouses from the parental depression group reported greater work/family stress. Finally, we found that although for both spouses children the awakening cortisol response was greater on weekdays than on weekend days, salivary cortisol levels did not differ between groups. Bayes factor calculated on the null result for cortisol levels was greater than 100, providing strong evidence for the null hypothesis H0. Altogether, these results suggest an impact of stigma toward mental health disorder on psychological markers of stress but no impact of stigma on physiological markers of stress. We suggest that these results may be due to the characteristics of the families who participated in the present study.
Invalid Baptismal Formulas: A Critical View on a Current Catholic Concern
Authors: Hahn Judith
Published: January 2021

In 2008 and 2020, the Congregation for the Doctrine of the Faith published two responses to questions posed regarding the validity of modified baptismal formulas. When administering baptism, some Catholic ministers had altered the prescribed formula with regard to the naming of the Trinity and with regard to the declarative introduction of the formula (ie ‘We baptise you …’ instead of ‘I baptise you …’). The Congregation dismissed all of these formulas as invalidating baptism and demanded that individuals baptised with these formulas be baptised again. In explaining its 2020 response the Congregation referred to Thomas Aquinas, who addressed these and similar issues in his sacramental theology. This reference is evidently due to Aquinas’ pioneering thoughts on the issue. However, in studying Aquinas’ work on the subject it is surprising to find that they reveal a far less literalist approach than the Congregation suggests. In fact, his considerations point at an alternative reading, namely that sacramental formulas should be understood as acts of communication which, based on the ministers’ intention of doing what the Church does, aim at communicating God's grace to the receivers in an understandable way.
The Role of the Faculty System in Achieving Net-Zero Carbon Emissions by 2030
Authors: Humphreys Jacqueline
Published: January 2021

The Church of England has committed itself to achieving net-zero carbon emissions by 2030. An important element required for success in this aim will be to amend the legislation around the management of church buildings and in particular the operation of the faculty jurisdiction. While aspects of the present system can and do facilitate some necessary change, to achieve the swift and widespread changes required within the timescale envisaged a more radical overhaul is required because the present faculty system favours the status quo, however bad that is from a carbon emissions perspective.
OPTIMAL LOCATION OF AN UNDERGROUND CONNECTOR USING DISCOUNTED STEINER TREE THEORY
Authors: SIRINANDA K. G. , BRAZIL M. , GROSSMAN P. A. , RUBINSTEIN J. H. , THOMAS D. A.
Published: January 2021

The objective of this paper is to demonstrate that the gradient-constrained discounted Steiner point algorithm (GCDSPA) described in an earlier paper by the authors is applicable to a class of real mine planning problems, by using the algorithm to design a part of the underground access in the Rubicon gold mine near Kalgoorlie in Western Australia. The algorithm is used to design a decline connecting two ore bodies so as to maximize the net present value (NPV) associated with the connector. The connector is to break out from the access infrastructure of one ore body and extend to the other ore body. There is a junction on the connector where it splits in two near the second ore body. The GCDSPA is used to obtain the optimal location of the junction and the corresponding NPV. The result demonstrates that the GCDSPA can be used to solve certain problems in mine planning for which currently available methods cannot provide optimal solutions.
State of the Art: ‘The People’ and Their Social Rights: What Is Distinctive About the Populism-Religion-Social Policy Nexus?
Authors: Jawad Rana , Béland Daniel , Pavolini Emmanuele
Published: January 2021

The aims of this review article are two-fold: (1) to set out the key theoretical trends in the study of religion, populism and social policy as antithetical concepts that also share common concerns; (2) to re-assert the relevance of social policy to the social and political sciences by making the case for studying outlier or indeed rival topics together – in this case populism and religion. Social policy scholars do not necessarily associate these two topics with modern social policy, yet they have a long history of influence on societies all over the world; populism is also especially timely in our current era. The article contributes to the literature by: (a) helping social policy better understand its diverse and at times contradictory constituencies; (b) contributing to a more complex and inclusive understanding of social policy and, therefore, social welfare. In setting out the state-of-the-art, the article also draws upon research on social policy which spans various continents (North America, Europe, the Middle East and North Africa and Latin America) and a preceding paper collaboration by the authors on religion and social policy (Pavolini et al., 2017).
In-cash Transfers: from Passive to Empowered Beneficiaries in the Global South
Authors: Fragoso Katarina Pitasse
Published: January 2021

Over the last few years, there has been an increase in discussions advocating in-cash programmes as a way to alleviate poverty. Indeed, this represents a leap forward in comparison to in-kind programmes. However, little progress, at least in developing countries, has been achieved in answering the question of how the state should transfer the means of redressing deprivation to those who are living in poverty. This article addresses this issue by challenging anti-poverty programmes through a social-egalitarian framework. My main argument starts from the perspective that in-cash transfers are a necessary but not sufficient mechanism for poverty alleviation. I acknowledge that cash alone does not guarantee the poor an equally active role in influencing the public-policy decisions that affect their lives. I then suggest a participatory device to complement the cash-transfer proposal in order to give institutional opportunities to the poor to decide, together with practitioners, what should be done at the level of local public services.
Genetic and Environmental Influences of Dietary Indices in a UK Female Twin Cohort
Authors: Mompeo Olatz , Gibson Rachel , Christofidou Paraskevi , Spector Tim D. , Menni Cristina , Mangino Massimo
Published: January 2021

A healthy diet is associated with the improvement or maintenance of health parameters, and several indices have been proposed to assess diet quality comprehensively. Twin studies have found that some specific foods, nutrients and food patterns have a heritable component; however, the heritability of overall dietary intake has not yet been estimated. Here, we compute heritability estimates of the nine most common dietary indices utilized in nutritional epidemiology. We analyzed 2590 female twins from TwinsUK (653 monozygotic [MZ] and 642 dizygotic [DZ] pairs) who completed a 131-item food frequency questionnaire (FFQ). Heritability estimates were computed using structural equation models (SEM) adjusting for body mass index (BMI), smoking status, Index of Multiple Deprivation (IMD), physical activity, menopausal status, energy and alcohol intake. The AE model was the best-fitting model for most of the analyzed dietary scores (seven out of nine), with heritability estimates ranging from 10.1% (95% CI [.02, .18]) for the Dietary Reference Values (DRV) to 42.7% (95% CI [.36, .49]) for the Alternative Healthy Eating Index (A-HEI). The ACE model was the best-fitting model for the Healthy Diet Indicator (HDI) and Healthy Eating Index 2010 (HEI-2010) with heritability estimates of 5.4% (95% CI [−.17, .28]) and 25.4% (95% CI [.05, .46]), respectively. Here, we find that all analyzed dietary indices have a heritable component, suggesting that there is a genetic predisposition regulating what you eat. Future studies should explore genes underlying dietary indices to further understand the genetic disposition toward diet-related health parameters.
Core‐Log‐Seismic Integration in Metamorphic Rocks and Its Implication for the Regional Geology: A Case Study for the ICDP Drilling Project COSC‐1, Sweden
Authors: Elger Judith , Berndt Christian , Kästner Felix , Pierdominici Simona , Kück Jochem , Almqvist Bjarne S. G. , Juhlin Christopher , Lorenz Henning
Published: January 2021

Continental collision causes deformation in the crust along shear zones. However, the physical and chemical conditions at which these zones operate and the deformation processes that enable up to hundreds of km of tectonic transport are still unclear because of the depth at which they occur and the challenges in imaging them. Ancient exhumed collision zones allow us to investigate these processes much better, for example at the COSC‐1 borehole in the central Scandinavian Caledonides. This study combines data from the COSC‐1 borehole with different seismic measurements to provide constraints on the spatial lithological and textural configuration of the Seve Nappe Complex. This is one of the few studies that shows that core‐log‐seismic integration in metamorphic rocks allows to identify the spatial distribution of major lithological units. Especially gamma ray logs in combination with density data are powerful tools to distinguish between mafic and felsic lithologies in log‐core correlation. Our results indicate that reflections along the borehole are primarily caused by compositional rather than textural changes. Reflections in the Seve Nappe Complex are not as distinct as in greater depths but continuous and several of them can be linked to magmatic intrusions, which have been metamorphically overprinted. Their setting indicates that the Seve Nappe Complex consists of the remnants of a volcanic continental margin. Our results suggest that ductile‐deformed middle crustal reflectivity is primarily a function of pre‐orogenic lithological variations which has to be considered when deciphering mountain building processes.
A Coupled Numerical Modeling Study of a Sea Fog Case After the Passage of Typhoon Muifa Over the Yellow Sea in 2011
Authors: Kim Subin , Moon Jae‐Hong , Kim Taekyun
Published: January 2021

Satellite remote sensing data revealed a widespread sea fog event over the central/southern Yellow Sea (YS), following Typhoon Muifa passage in August 2011. Despite the importance of sea fog prediction for coastal safety, improving accuracy remains a challenging issue. By analyzing results from air‐sea coupled and uncoupled simulations, this study aims to investigate how the air‐sea coupling improves the sea fog formation and duration and examine atmospheric responses to spatiotemporally varying sea surface temperature (SST) over the YS. Unlike the uncoupled model, the SST simulated by the coupled model dramatically decreased and maintained its low temperature for more than a week after the typhoon passed over the YS, showing better agreement with the observations. The sharp SST decrease over the YS cools the air temperature at low‐level atmosphere and enhances horizontal convergence in the moisture flux over the cooler ocean, which provides favorable conditions for sea fog formation. The long‐lasting oceanic cooling stabilizes the atmospheric boundary layer and suppresses atmospheric vertical mixing, delaying the dissipation of sea fog for more than a week. This study highlights that air‐sea coupling can improve the sea fog simulation by providing more realistic oceanic conditions.
Evidence of Exposed Dusty Water Ice within Martian Gullies
Authors: Rai Khuller Aditya , Russel Christensen Philip
Published: January 2021

Midlatitude slopes on Mars are mantled by deposits proposed to contain H2O ice and dust, overlaid by a desiccated lag. However, direct evidence of their volatile content is lacking. Here we present novel evidence of light‐toned materials within midlatitude gully alcoves eroded into these mantles. The appearance and Lambert albedo of these materials suggests that they are either dust or H2O ice. We interpret them to be H2O ice because it is unlikely for a short‐term, localized dust deposit to form only within the mantle walls. The temperatures are generally too warm (>∼240 K) for the ice to be a frost in equilibrium. Therefore, this ice is likely similar to the dusty ice documented within midlatitude scarps, but with more dust, and exposed in smaller patches by slumping. It has been proposed that CO2 frosts remove the overlying lag, causing the exposed H2O ice to sublimate, liberate dust within the ice for transport, and erode gullies in the mantle. But we observe gullies eroded in wall rock that continue into the mantle, implying that the same process erodes both substrates. H2O ice melt can explain gullies eroded in the wall rock and the mantle. Numerical models show that relatively dense H2O snow on Mars melts only when it contains small amounts of dust. The observed exposure of dusty ice provides a mechanism for it to melt under some conditions and form some gullies. Access to liquid water within this ice could provide potential abodes for any extant life.
Vertically Resolved Magma Ocean–Protoatmosphere Evolution: H2, H2O, CO2, CH4, CO, O2, and N2as Primary Absorbers
Authors: Lichtenberg Tim , Bower Dan J. , Hammond Mark , Boukrouche Ryan , Sanan Patrick , Tsai Shang‐Min , Pierrehumbert Raymond T.
Published: January 2021

The earliest atmospheres of rocky planets originate from extensive volatile release during magma ocean epochs that occur during assembly of the planet. These establish the initial distribution of the major volatile elements between different chemical reservoirs that subsequently evolve via geological cycles. Current theoretical techniques are limited in exploring the anticipated range of compositional and thermal scenarios of early planetary evolution, even though these are of prime importance to aid astronomical inferences on the environmental context and geological history of extrasolar planets. Here, we present a coupled numerical framework that links an evolutionary, vertically resolved model of the planetary silicate mantle with a radiative‐convective model of the atmosphere. Using this method, we investigate the early evolution of idealized Earth‐sized rocky planets with end‐member, clear‐sky atmospheres dominated by either H2, H2O, CO2, CH4, CO, O2, or N2. We find central metrics of early planetary evolution, such as energy gradient, sequence of mantle solidification, surface pressure, or vertical stratification of the atmosphere, to be intimately controlled by the dominant volatile and outgassing history of the planet. Thermal sequences fall into three general classes with increasing cooling timescale: CO, N2, and O2with minimal effect, H2O, CO2, and CH4with intermediate influence, and H2with several orders of magnitude increase in solidification time and atmosphere vertical stratification. Our numerical experiments exemplify the capabilities of the presented modeling framework and link the interior and atmospheric evolution of rocky exoplanets with multiwavelength astronomical observations.
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy
Authors: Bhat Ajaz A. , Yousuf Parvaiz , Wani Nissar A. , Rizwan Arshi , Chauhan Shyam S. , Siddiqi Mushtaq A. , Bedognetti Davide , El-Rifai Wael , Frenneaux Michael P. , Batra Surinder K. , Haris Mohammad , Macha Muzafar A.
Published: January 2021

Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC. Despite significant advances in multimodal therapeutic interventions, failure to cure and recurrence are common and account for most deaths. It is becoming increasingly apparent that tumor microenvironment (TME) plays a critical role in HNSCC tumorigenesis, promotes the evolution of aggressive tumors and resistance to therapy, and thereby adversely affects the prognosis. A complete understanding of the TME factors, together with the highly complex tumor–stromal interactions, can lead to new therapeutic interventions in HNSCC. Interestingly, different molecular and immune landscapes between HPV+veand HPV−ve(human papillomavirus) HNSCC tumors offer new opportunities for developing individualized, targeted chemoimmunotherapy (CIT) regimen. This review highlights the current understanding of the complexity between HPV+veand HPV−veHNSCC TME and various tumor–stromal cross-talk modulating processes, including epithelial–mesenchymal transition (EMT), anoikis resistance, angiogenesis, immune surveillance, metastatic niche, therapeutic resistance, and development of an aggressive tumor phenotype. Furthermore, we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV+veand HPV−veHNSCC.
Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation
Authors: Rogerson Clare , Wotherspoon Duncan J. , Tommasi Cristina , Button Robert W. , O’Shaughnessy Ryan F. L.
Published: January 2021

Keratinocyte cornification and epidermal barrier formation are tightly controlled processes, which require complete degradation of intracellular organelles, including removal of keratinocyte nuclei. Keratinocyte nuclear destruction requires Akt1-dependent phosphorylation and degradation of the nuclear lamina protein, Lamin A/C, essential for nuclear integrity. However, the molecular mechanisms that result in complete nuclear removal and their regulation are not well defined. Post-confluent cultures of rat epidermal keratinocytes (REKs) undergo spontaneous and complete differentiation, allowing visualisation and perturbation of the differentiation process in vitro. We demonstrate that there is dispersal of phosphorylated Lamin A/C to structures throughout the cytoplasm in differentiating keratinocytes. We show that the dispersal of phosphorylated Lamin A/C is Akt1-dependent and these structures are specific for the removal of Lamin A/C from the nuclear lamina; nuclear contents and Lamin B were not present in these structures. Immunoprecipitation identified a group of functionally related Akt1 target proteins involved in Lamin A/C dispersal, including actin, which forms cytoskeletal microfilaments, Arp3, required for actin filament nucleation, and Myh9, a component of myosin IIa, a molecular motor that can translocate along actin filaments. Disruption of actin filament polymerisation, nucleation or myosin IIa activity prevented formation and dispersal of cytoplasmic Lamin A/C structures. Live imaging of keratinocytes expressing fluorescently tagged nuclear proteins showed a nuclear volume reduction step taking less than 40 min precedes final nuclear destruction. Preventing Akt1-dependent Lamin A/C phosphorylation and disrupting cytoskeletal Akt1-associated proteins prevented nuclear volume reduction. We propose keratinocyte nuclear destruction and differentiation requires myosin II activity and the actin cytoskeleton for two intermediate processes: Lamin A/C dispersal and rapid nuclear volume reduction.
Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis
Authors: Lu Min , Qin Xinglei , Zhou Yajun , Li Gang , Liu Zhaoyang , Geng Xiwen , Yue Haodi
Published: January 2021

Gemcitabine is the first-line chemotherapy drug for cholangiocarcinoma (CCA), but acquired resistance has been frequently observed in CCA patients. To search for potential long noncoding RNAs (lncRNAs) involved in gemcitabine resistance, two gemcitabine resistant CCA cell lines were established and dysregulated lncRNAs were identified by lncRNA microarray. Long intergenic non-protein coding RNA 665 (LINC00665) were found to rank the top 10 upregulated lncRNAs in our study, and high LINC00665 expression was closely associated with poor prognosis and chemoresistance of CCA patients. Silencing LINC00665 in gemcitabine resistant CCA cells impaired gemcitabine tolerance, while enforced LINC00665 expression increased gemcitabine resistance of sensitive CCA cells. The gemcitabine resistant CCA cells showed increased EMT and stemness properties, and silencing LINC00665 suppressed sphere formation, migration, invasion and expression of EMT and stemness markers. In addition, Wnt/β-Catenin signaling was activated in gemcitabine resistant CCA cells, but LINC00665 knockdown suppressed Wnt/β-Catenin activation. B-cell CLL/lymphoma 9-like (BCL9L), the nucleus transcriptional regulators of Wnt/β-Catenin signaling, plays a key role in the nucleus translocation of β-Catenin and promotes β-Catenin-dependent transcription. In our study, we found that LINC00665 regulated BCL9L expression by acting as a molecular sponge for miR-424-5p. Moreover, silencing BCL9L or miR-424-5p overexpression suppressed gemcitabine resistance, EMT, stemness and Wnt/β-Catenin activation in resistant CCA cells. In conclusion, our results disclosed the important role of LINC00665 in gemcitabine resistance of CCA cells, and provided a new biomarker or therapeutic target for CCA treament.
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway
Authors: Fang Shaohong , Wan Xin , Zou Xiaoyi , Sun Song , Hao Xinran , Liang Chenchen , Zhang Zhenming , Zhang Fangni , Sun Bo , Li Hulun , Yu Bo
Published: January 2021

Inducing autophagy and inhibiting apoptosis may provide a therapeutic treatment for atherosclerosis (AS). For the treatment of progressive AS, arsenic trioxide (ATO) has been used to coat vascular stents. However, the effect of ATO on autophagy of macrophages is still unknown. Therefore, the aims of this study were to characterize the effects and the mechanism of actions of ATO on autophagy in macrophages. Our results showed that ATO-induced activation of autophagy was an earlier event than ATO-induced inhibition of the expression of apoptosis markers in macrophages and foam cells. Nuclear transcription factor EB (TFEB) prevents atherosclerosis by activating macrophage autophagy and promoting lysosomal biogenesis. Here, we report that ATO triggered the nuclear translocation of TFEB, which in turn promoted autophagy and autophagosome-lysosome fusion. Both the latter events were prevented by TFEB knockdown. Moreover, ATO decreased the p-AKT and p-mTOR in the PI3K/AKT/mTOR signaling pathway, thus inducing autophagy. Correspondingly, treatment with the autophagy inhibitor 3-methyladenine (3-MA) abolished the autophagy-inducing effects of ATO. Meanwhile, PI3K inhibitor (LY294002) and mTOR inhibitor (rapamycin) cooperated with ATO to induce autophagy. Furthermore, reactive oxygen species (ROS) were generated in macrophages after treatment with ATO. The ROS scavenger N-acetyl-1-cysteine (NAC) abolished ATO-induced nuclear translocation of TFEB, as well as changes in key molecules of the AKT/mTOR signaling pathway and downstream autophagy. More importantly, ATO promoted autophagy in the aorta of ApoE−/−mice and reduced atherosclerotic lesions in early AS, which were reversed by 3-MA treatment. In summary, our data indicated that ATO promoted ROS induction, which resulted in nuclear translocation of TFEB and inhibition of the PI3K/AKT/mTOR pathway. These actions ultimately promoted macrophage autophagy and reduced atherosclerotic lesions at early stages. These findings may provide a new perspective for the clinical treatment of early-stage atherosclerosis and should be further studied.
Survival control of oligodendrocyte progenitor cells requires the transcription factor 4 during olfactory bulb development
Authors: Zhang Yilan , Cai Yuqun , Wang Yafei , Deng Xin , Zhao Yifan , Zhang Yubin , Xie Yunli
Published: January 2021

A proper number of oligodendrocytes in the nerve system is essential for neuronal functions. In the olfactory bulb (OB), enriched oligodendrocytes are crucial for olfactory information processing. However, how the precise number of oligodendrocytes in the OB is regulated remains elusive. Here we identified that the transcription factor 4 (Tcf4)-mediated cell death is essential for generating an appropriate number of oligodendrocyte progenitor cells (OPCs) and thereby oligodendrocytes in the OB. We showed that Nkx2.1-positive progenitors in the medial ganglionic eminence (MGE) and anterior entopeduncular area (AEP) provide the first source of OPCs in the OB. Conditional depletion of Tcf4 leads to an increase of OPCs in the OB, which is mediated by the suppression of programmed cell death. Furthermore, we showed that Tcf4 mediated OPC survival is cell-autonomous by transplantation assay. Mechanistically, we identified Bax/Bak as a potential key pathway to promote OPC elimination during OB development. Depletion of Bax/Bak in Nkx2.1 lineage results in an increase of OPCs in the OB. Mutations in TCF4 causes Pitt-Hopkins syndrome, a severe neurodevelopmental disorder. Thus, our findings reveal an important intrinsic mechanism underlying the survival control of OPCs in the OB and provide new insights into the pathogenesis of Pitt–Hopkins syndrome.