bluuebunny/crossref_metadata_2025 huggingface dataset:
IMMUNE RESPONSE TO SARS CoV2 INFECTION BY TLR3, TLR4 AND TLR7 GENE EXPRESSION.
Authors: L MARTINEZ MARIGNAC VERONICA , GLORIA OERTLIN , Favant Jose Luis , Fleischmann Erika , SALINAS MERCEDES , MARCHETTI GASTON , GASSALI ZAIDA , Richard Silvina M.
Published: May 2023

Toll-like receptors (TLRs) may be involved both in the initial failure
of viral clearance and in the subsequent development of severe clinical
manifestations of COVID-19, essentially ARDS (acute respiratory distress
syndrome) with fatal respiratory failure. We present the gene expression
of TLR 3, 4, and 7 in nasopharyngeal total RNA samples from 150
individuals positive for SARS Cov2 (DET) by molecular techniques of
isothermal amplification (Neokit SA) and 152 SARS Cov2 non detectable
(ND) ambulatory and hospitalized patients with a non-defined respiratory
disease, and we compared with the symptomatology developed by all those
patients. We analyzed 4 cohorts: 1-SARS Cov2 genome detected patients
with severe to high symptomatology (n=107); 2-SARS Cov2 genome detected
patients low to mild symptomatology (n=43); 3-SARS Cov2 genome non
detected patients with severe to high symptomatology (n=109); and 4-SARS
Cov2 genome non detected patients low to mild symptomatology (n=41). Our
results not only contradict few previous study, it also corrects for
sample size bias, showing no significant differences of expression for
TLR3, TLR4 and TLR7 between SARS Cov2 DET and ND total cohort of
patients (Non Paired T –Test p Value>0.1). When compared
severity of symptoms -presence of symptoms from the COVID-19 12 WHO
diagnosis symptoms- and gene expression, here we found significant
positive correlation between severe symptomatology, and the number of
symptoms and death for TLR4 and TLR7 for both DET and ND COVID-19
patients. When the cohort was construct with low/middle and severe
symptoms, the Correlation Coefficient showed that expression of TLR4 and
TLR7 was significantly amplified in those ND patients with severe
symptomatology ( p Value= 0.00311) as well as for TLR3 in ND low
to mild symptoms cohort of patients. We also showed and discussed the
results obtained of these genes expression and the sex and age of
patients. In summary, our data suggest that although our innate immune
system with TLRs contributes to the elimination of viruses, it can also
be associated with harm to the host due to persistent inflammation and
tissue destruction. We confirmed that principally TLR4 and TLR7 could be
involved not only in the pathogenesis of COVID‐19 but also in other
respiratory diseases with same symptomatology. We agree with previous
studies that treatments focus on TLR4 and TLR7 expression in
inflammatory respiratory diseases could be a start point against severe
symptoms development.
Global distribution and climatic preferences of C4 eudicots and how they differ from those of C4 grasses
Authors: Berasategui Jessica , Čalasan Anže Žerdoner , Zizka Alexander , Kadereit Gudrun
Published: May 2023

C is one of three known photosynthetic processes of
carbon fixation in flowering plants. It evolved independently more than
61 times in multiple angiosperm lineages and consists of a series of
anatomical and biochemical modifications to the ancestral
C pathway increasing plant productivity under warm and
light-rich conditions. The C lineages of eudicots
belong to seven orders and 15 families, are phylogenetically less
clustered than those of monocots, and entail an enormous structural and
ecological diversity. Eudicot C lineages likely evolved
the C syndrome along different evolutionary paths.
Therefore, a better understanding of this diversity is key to
understanding the evolution of this complex trait as a whole. Compiling
1,207 recognized C eudicots species described in the
literature and presenting trait data among these species, we identify
global centres of species richness and of high phylogenetic diversity.
Furthermore, we discuss climatic preferences in the context of plant
functional traits. We identify two hotspots of C
eudicot diversity: arid regions of Mexico/Southern United States and
Australia, where several C eudicot lineages diversified
independently. Further eudicot C hotspots with many
different families and genera represented are in South Africa, West
Africa, Patagonia, Central Asia and the Mediterranean. In general,
C eudicots were abundant in deserts and xeric
shrublands, tropical and subtropical grasslands, savannas and
shrublands. We found C eudicots to occur in areas with
less annual precipitation than C grasses which can be
explained by frequently associated adaptations to drought stress such as
among others succulence and salt tolerance. We conclude that in most
eudicot lineages C evolved in ancestrally drought
adapted clades and enabled these to further spread in these habitats and
colonise even drier areas.
ACUTE AND SUBACUTE ORAL TOXICITY ASSESSMENT OF THE POLYSACCHARIDES EXTRACTED FROM CLINACANTHUS NUTANS LEAVES: A PRECLINICAL MODEL FOR DRUG SAFETY SCREENING
Authors: Tan Yong Chia , Gan Chee-Yuen , Kaur Gurjeet , Cheah Pike-See , Murugaiyah Vikneswaran , Ahmad Ashfaq , Shafie Muhammad Hakimin , Nair Selvamani Narayan , Abdulla "Mohammed H. , Johns Edward
Published: May 2023

Emerging investigations have indicated that many plant polysaccharides
may be beneficial in treating metabolic diseases. Hitherto, the
therapeutic efficacies and the potential toxicity of polysaccharides
extracted from Clinacanthus nutans (C. nutans) remains unexplored. This
investigation studied on the in-vivo acute and sub-acute oral
toxicological profile of the highest doses of C. nutans bioactive
polysaccharides (CNBP) extracted from leaves using conventional toxicity
methods. 39 healthy 8-10 weeks male Sprague-Dawley rats (n=3), were
randomly assigned into: control, acute and sub-acute groups receiving
125, 250, 500, 1000, 2000, and 3000 mg/kg/day of CNBP extract
respectively; acute groups received a single dose of CNBP extract;
whereas the sub-acute groups received daily single doses of CNBP extract
for 14 days. Oral administration of up to 3000 mg/kg of CNBP extract
caused no abnormal toxicity signs during the 14 days. However, daily
administration of 500 mg/kg or higher doses of CNBP extract for 14 days
induced a mild degree of toxicity in the liver characterized by elevated
alkaline phosphatase levels. The CNBP extracts exhibit therapeutic
potential, exemplified by diuretic, natriuretic, anti-hypertensive,
anti-tachycardia, reno-protective, and cholesterol lowering properties.
Precaution should be taken when administrating the extracts at higher
doses and longer durations.
Comparison efficiency of Isotope Ratio Mass Spectrometry Coupled to Liquid Chromatography Method and the Conventional Methods to Identify Honey Adulteration, Iran
Authors: Khansari Nafiseh , Alimoradian Abbas , Abdollahi Mehdi , Asl Behnoosh Ansari , Asadi Sonia , maghool Akbar yousefi , Rabiei Arash , Khademi Ali
Published: May 2023

Rationale Over the years, many techniques have been developed
for honey adulteration detection. The several methods based on the AOAC
have been admitted to the in-house method confirmed by Iranian Standard
Organization (ISIRI). Besides the unprecedented fraud in honey, the
scientific requirements to apply high-tech procedures. Therefore,
unraveling these discrepancies requires comparisons between the elderly
and novel methods. Methods The conventional methods determined
different parameters such as reducing sugars before hydrolysis, sucrose
amount, fructose to glucose ratio, Proline, and hydroxy methyl furfural.
Applying novel IRMS technique determined δ13C values for glucose with
high quality and quantity. The honey carbohydrates, such as glucose,
fructose, disaccharide, and trisaccharide, were assessed using LC/IRMS.
Results Based on these findings regarding the conventional and
IRMS methods for testing samples. According to our results, the
conventional method successfully passed 18 to 20 samples by ISIRI
standards. However, the IRMS method showed different results, with only
2 out of 20 samples being original and pure without adulteration.
Conclusion We collected twenty samples from various regions and
examined them using two methods to determine their authenticity. The
first method used is the C13 isotope and isotope ratio mass spectrometry
(IRMS), while the second method is based on conventional methods using
ISIRI. After analyzing the results with Prism software, we found a
statistically significant difference between the confidence level of the
IRMS method and conventional methods, with a p-value less than 0.05.
Hierarchical Rule-Base Reduction Fuzzy Control for Constant Velocity Path Tracking of a Differential Steer Vehicle
Authors: Dekhterman Samuel R. , Cichon Maxwel , Norris William R. , Nottage Dustin , Soylemezoglu Ahmet
Published: May 2023

A new form of waypoint navigation controller for a skid-steer vehicle is
presented, which consisted of a multiple input-single output nonlinear
fuzzy angular velocity controller. The mem- bership functions of the
fuzzy controller employed a trape- zoidal structure with a completely
symmetric rule-base. No- tably, Hierarchical Rule-Base Reduction (HRBR)
was incorpo- rated into the controller to select only the rules most
influen- tial on state errors. This was done by selecting inputs/outputs
and generating a hierarchy of inputs using a Fuzzy Relations Control
Strategy (FRCS). Similar to some traditional fuzzy con- trollers, the
system provided coverage for the global operat- ing environment.
However, a rule for every possible combi- nation of variables and states
was no longer necessary. Con- sequently, HRBR fuzzy controllers
effectively increase both the number of inputs and their associated
fidelity without the rule-base dramatically increasing. To contextualize
the performance of the controller, a background on vehicle dy- namic
modeling methodologies and an in-depth explanation of the related
simulation model are provided. An examina- tion of the proposed
controller is then completed employing test courses. The test courses
examine the effects of steer- ing disturbance, phase lag, and overshoot
as expressed in Root Mean Square Error (RMSE), Max Error (ME), and
Course Completion Time (CCT). Finally, simulation and experimental
results for the controller’s performance were compared with a
state-of-the-art waypoint navigation vehicle controller, ge- ometric
pure pursuit. The fuzzy was found to outperform the pure pursuit
experimentally by 52.1 percent in RMSE, 26.8 percent in ME, and 1.07
percent in CCT, on average, validat- ing the viability of the
controller.
Post Radiation Middle Ear Effusion in NPC Patients - Analysis of Patient, Tumor and Radiation Factors
Authors: Vainer Igor , Tzelnick Sharon , kurman noga , Popovtzer Aron , Soudry Ethan
Published: May 2023

Introduction: The purpose of this study was to investigate whether
patient, tumor and radiation therapy factors are associated with
development of middle ear effusion (MEE) in nasopharyngeal carcinoma
(NPC) patients. Methods: A retrospective review of NPC patients treated
between January 2000 and June 2018 at Rabin Medical Center. Patient
factors, tumor factors, radiation doses and radiation fields were
collected and outlined if needed (middle ear, eustachian tube (ET),
tensor veli palatini (TVP) and levator palatini (LVP) muscles), then
analyzed and compared between patients with MEE and those without and
between sides in patients with unilateral MEE. Results: 73 patients were
enrolled. Most were males (71.2%) with advanced stage diseases (78%).
At the time of diagnosis 14 patients (19.2%) presented with MEE and in
18 (24.6%) patients post radiation MEE was observed (15 ipsilateral to
the tumor and 3 bilateral). Tumor stage, histology and laterality were
not associated with development of MEE. Comparison of mean radiation
field dosages including - gross target volume (GTV), clinical target
volume (CTV) and patient target volume (PTV) showed no association with
post radiation MEE. In addition, no difference was found in the
radiation doses to the middle ear, ET or the LVP nor the TVP between
ears with and without MEE. Conclusions: Postirradiation MEE remains a
common adverse effect in NPC patients. Surprisingly, tumor stage, tumor
laterality and histology were not associated with MEE. Similar findings
were observed for total radiation doses and specific doses to the middle
ear, ET and ET muscles.
Unpacking the Digital Inequalities in Online Job Search: Turkish Older Women Workers in Pink-Collar Occupations
Authors: Sarı Burçin , Rızvanoğlu Kerem
Published: May 2023

The study investigates the job search of Turkish older women workers in
pink-collar occupations in both the offline and online worlds, with the
goal of identifying barriers encountered during online job search as
well as highlighting its latent potential. Our sample is formed by ten
older women (ages 55–59) who currently work in jobs that do not require
basic computer and internet skills. By focusing on their first-time
e-recruitment experience through an online job search platform, we
employed a multi-method research approach that includes pre-interview
procedures, task-based observation, the think-aloud protocol during task
execution, and post-interview evaluations. The findings indicate that
offline job searching is challenging for older women workers due to time
and cost intensity, physical and mental strain, and direct ageism. In
contrast, online job searches offers accessibility, cost-effectiveness,
flexibility, autonomy, and a reduced risk of age discrimination.
However, digital inequalities, including access, autonomy of use,
internet skills, purpose of use and limited social support impede the
active use of online job platforms by our sample group. The removal of
these barriers will not only contribute to greater economic integration
of women, but will also provide a tangible opportunity to overcome
traditional gender norms.
Performance of GPCP Products Over Oceans: Evaluation Using Passive Aquatic Listeners
Authors: Li Zhe , Thompson Elizabeth J , Behrangi Ali , Chen Haonan , Yang Jie
Published: May 2023

Passive Aquatic Listeners (PALs) have been increasingly deployed to
collect minute-scale surface oceanic rainfall and wind information, with
a sampling area similar to the spaceborne sensor footprints. This
provides an unprecedented opportunity to validate satellite
precipitation products over oceans. This study evaluates the Global
Precipitation Climatology Project (GPCP) daily products, including the
widely-used GPCP v1.3 and the newly released GPCP v3.2, over oceans
using 58 PALs as references. The study shows that the GPCP performance
depends on time scale, region, and rainfall intensity. The two versions
of GPCP perform similarly at multi-year and monthly scales, while GPCP
v3.2 shows substantial improvements in representing rain occurrence and
rain intensity at daily scale. The results also highlight the challenge
of precipitation measurement over certain regions such as the tropical
Northeastern Pacific and extratropical North Pacific, where both
versions of the GPCP products perform similarly but exhibit noticeable
differences compared to PAL observations.
Wall Fracturing versus Mechanical Instability as Competing Intrusion Mechanisms of Dikes: Insights from Laboratory Experiments
Authors: Biswas Uddalak , Mitra Atin Kumar , Mandal Nibir
Published: May 2023

Igneous dike intrusion is a primary crust-forming process at the Earth’s
plate boundaries. Understanding its mechanism is thus crucially
important in lithospheric studies. Our present article combines
experimental and field observations to investigate the problem of dike
emplacement from a mechanical perspective. We performed scaled
laboratory experiments by injecting immiscible liquids into
visco-elastic and visco-elasto-plastic host materials at varying
volumetric flow rates (VFR = 0.100 ml/sec to 1.670 ml/sec). Another set
of experiments used different injecting liquid–host combinations to set
their viscosity ratios (η*) at low (105), moderate (106), and (iii) high
(109) values. These two lines of experiments allow us to recognize three
principal mechanisms of liquid pathways: 1) tensile fracturing of the
host, 2) wave instability at the liquid-host interface and coupled
fracturing-wave instability process. The three mechanisms give rise to a
wide variation in intrusion geometry, ranging from planar structures
with elliptical outlines to typical bulbous geometry, with intermediate
patterns characterized by in-plane and off-plane wavy interfaces with
the host. We use the experimental data to constrain the VFR conditions
that determine the fracturing versus wave instability-controlled
mechanisms. It is also shown from the experiments that η* can
significantly influence the evolution of three-dimensional intrusive
geometry. The Chotonagpur Granite Gneiss Complex in eastern India is
chosen as our study area to validate our laboratory findings using a 2D
shape analysis of the intrusive boundaries in terms of their fractal
dimensions (D) and skewness-kurtosis estimates.
Polarity and Timing of the Deformation along the Jinsha Suture Zone (Yushu area, Northeastern Tibet)
Authors: Goussin Fanny , Guillot Stéphane , Ruffet Gilles , Poujol Marc , Oliot Émilien , Replumaz Anne , Cordier Carole , Dupont-Nivet Guillaume , Roperch Pierrick
Published: May 2023

The Tibetan Plateau was formed by intense Cenozoic shortening (up to
1100 km) of a composite “proto-Tibet”, itself the product of a long
Paleozoic and Mesozoic history of accretion of Gondwana-derived
continental fragments and volcanic arcs against the Asian continental
margin. The difficult access and the scarcity of outcrops have long
limited the possibilities of studying these Mesozoic suture zones in the
heart of the Plateau. In this work, we present new U-Pb and 40Ar/39Ar
ages from the highly deformed units of the Yushu mélange, along the
Jinsha Suture in the northeastern Qiangtang terrane. Early Triassic (c.
253 Ma) to Middle Jurassic ages (c. 165 Ma) complement the existing
dataset and help to refine the chronology of the Paleo-Tethyan oceanic
subductions which have structured the northeastern part of the Qiangtang
terrane. The Yushu mélange records at least three successive
tectono-magmatic events. The opening of a back-arc basin during the
northward Paleo-Tethyan subduction along the Longmu Co-Shuanghu Suture
during Early to Middle Triassic; then its closure during the southward
subduction of the Songpan-Ganze Ocean along the Jinsha Suture in Late
Triassic. Finally, a shortening phase related to the continental
collision of the Songpan-Ganze and Qiangtang blocks from Late Triassic
to Early-Middle Jurassic. No evidence for any high- or mid-temperature
Cenozoic reactivation of the Jinsha suture in our study area is
recorded.
SatVITS-Flood: Satellite Vegetation Index Time Series Flood detection model for hyperarid regions
Authors: Burstein Omer , Grodek Tamir , Enzel Yehouda , Helman David
Published: May 2023

We present the Satellite Vegetation Index Time Series model for
detecting historical floods in ungauged hyperarid regions
(SatVITS-Flood). SatVITS-Flood is based on observations that floods are
the primary cause of local vegetation expansion in hyperarid regions. To
detect such expansion, we used two time series metrics: (1) trend change
detection from the Breaks For Additive Season and Trend (BFAST-trend)
and (2) a newly developed seasonal change metric based on Temporal
Fourier Analysis (TFA) and the growing-season integral anomaly
(TFA-GSIanom). The two metrics complement each other by capturing
changes in perennial species following extreme, rare floods and
ephemeral vegetation changes following more frequent floods. Metrics
were derived from the time series of the normalized difference
vegetation index (NDVI), the modified soil-adjusted vegetation index
(MSAVI), and the normalized difference water index (NDWI), acquired from
MODIS, Landsat, and AVHRR. The timing of the change was compared with
the date of the flood and the magnitude of change with its volume and
duration. We tested SatVITS-Flood in three regions on different
continents with 40 years long, systematic, reliable gauge data. Our
results indicate that SatVITS-Flood can predict flood occurrence with an
accuracy of 78% and precision of 67% (Recall=0.69 and F1=0.68;
p<0.01), and the flood volume and duration with NSE of 0.79
(RMSE=15.4 Mm3 event–1), and R2 of 0.69 (RMSE=5.7 days), respectively.
SatVITS-Flood proved useful for detecting historical floods and may
provide valuable long-term hydrological information in poorly-documented
areas, which can help understand the impacts of climate change on the
hydrology of hyperarid regions.
UNA CIUDAD SOSTENIBLE STEM PARA MEJORAR LA ACTITUD HACIA LAS CIENCIAS LAS Y MATEMÁTICAS EN ESTUDIANTES DE 5° Y 6° DE EDUCACIÓN PRIMARIA DE ESPAÑA
Authors: Ferrada Cristian Andrés , Carrillo-Rosúa Francisco Javier , Díaz-Levicoy Danilo Antonio Díaz-Levicoy Antonio , Silva-Díaz Francisco Raul Silva-Díaz Raul
Published: May 2023

Se presenta una investigación asociada a la implementación de un proyecto interdisciplinario, con enfoque STEM, aplicado en un centro educativo de Educación Primaria en un contexto vulnerable. El trabajo con los estudiantes se realizó según una metodología de indagación y resolución de problemas. Se sigue un diseño cuasi-experimental, utilizando como variables dependientes la actividad de ciencias y matemáticas, analizadas pre-intervención y post-intervención. El grupo experimental estuvo formado por 15 alumnos de 3º ciclo, formando el grupo de control a partir de un proceso de emparejamiento con el resto de alumnos del centro.Las conclusiones indican que la implementación del programa STEM genera mejores resultados en actividades de ciencias (p=.004 TE= 1.254) que en matemáticas (p=.574 TE=, 382) en las herramientas tecnológicas utilizadas, en el tiempo de trabajo y en el proceso de conexión entre disciplinas en STEM refuerza el trabajo realizado. Finalmente, la investigación implica que existe la necesidad de aumentar la comprensión de las interrelaciones entre los aspectos STEM y la necesidad de desarrollar modelos de aprendizaje basados en STEM para apoyar la aplicación de STEM en el aprendizaje.
DO SILÊNCIO À DISCUSSÃO SOBRE GÊNERO EM UM ESPAÇO DE FORMAÇÃO CONTINUADA DE DOCENTES DE CIÊNCIAS E MATEMÁTICA
Authors: Soares Bento Andressa , Cury Soares Alessandro , Dos Santos Pastoriza Bruno , Sangiogo Fábio André
Published: May 2023

A presença das mulheres na universidade e na pesquisa pode ser considerada uma posição de resistência, visto que o gênero feminino enfrenta diversas problemáticas para se fazer presente nestes e em outros espaços de poder. Como forma de quebrar o silêncio perante algumas problemáticas de gênero, este artigo apresenta resultados de uma intervenção didática desenvolvida para o componente curricular de História e Filosofia da Ciência, no Programa de Pós-Graduação em Ensino de Ciências e Matemática de uma Universidade Federal. Neste artigo, se discutem questões que atravessam a diversidade de gênero em diferentes espaços, em especial, no acadêmico e escolar. As categorias emergentes nele apresentadas se deram a partir dos registros de aulas e questionários realizados pelos docentes matriculados no componente curricular, desenvolvidas a partir da Análise de Conteúdo. Os resultados permitem compreender que a atividade proposta teve seu objetivo atingido em questão da promoção da discussão sobre gênero em diferentes espaços. Evidenciou-se ademais que o meio acadêmico ainda não é um espaço representativo, e que o silêncio e os desabafos de professores sobre as questões que envolvem representatividade e diversidade denotam a importância de espaços de informação, de formação e de reflexão, na formação inicial e continuada, na escola e na sociedade como um todo.
O CONSTRUTO DE PRÁTICAS EPISTÊMICAS EM PESQUISAS BRASILEIRAS EM EDUCAÇÃO EM CIÊNCIAS
Authors: Martiliano Milena Luciana , Munford Danusa , Correia Fernandes Priscila
Published: May 2023

Neste artigo apresentamos um estudo de revisão bibliográfica a partir de artigos brasileiros da área de Educação em Ciências que empregam o construto de Práticas Epistêmicas (PEs). O corpus constitui-se de dezoito artigos de periódicos classificados como Qualis A1 ou A2, publicados entre 2008 e 2021. Foram analisados os focos temáticos das pesquisas, as definições de PEs presentes, o diálogo com a obra de Gregory Kelly e as metodologias utilizadas. Os resultados evidenciam que: i) o construto tem sido explorado com mais frequência em pesquisas sobre o Ensino de Ciências por Investigação; ii) além das definições de PEs, a maioria dos artigos nacionais faz uso de outras ideias concebidas e apoiadas por Kelly; iii) o aspecto mais comum é que a construção do conhecimento científico no interior de uma comunidade envolve proposição, comunicação, avaliação e legitimação, e que a promoção do engajamento em PEs deve figurar dentre os objetivos didáticos de aulas de ciências; iv) a produção analisada não compartilha referenciais teórico-metodológicos que orientaram os trabalhos de Kelly sobre PEs, como a Etnografia Interacional. Argumentamos que as PEs têm o potencial de contribuir para avanços das discussões no campo da Educação em Ciências no Brasil no sentido de delimitar os pressupostos de teorias e de estudos empíricos, assim como indicar novas direções de pesquisa e agregar novos membros à comunidade produtora de conhecimento.
BASES CONCEPTUALES Y METODOLÓGICAS DE UNA PROPUESTA DE FORMACIÓN SOPORTADA EN TIC PARA PROFESORES DE QUÍMICA EN FORMACIÓN INICIAL
Authors: Abella-Peña Leonardo Enrique , García-Martinez Alvaro
Published: May 2023

El desarrollo de habilidades tecnológicas y digitales por parte del profesorado en todos los niveles educativos es una necesidad imperante. Con este documento se propone una estrategia de formación para profesores de química mediante el diseño didáctico y la incorporación de recursos TIC. El objetivo de este artículo es aportar en términos de resultados, los alcances de una propuesta didáctica de formación docente en TIC orientada mediante una comunidad de desarrollo profesional para profesores de química (CODEP) en formación inicial (FI) gestionada mediante ciclos iterativos desde la perspectiva de la investigación de diseño educativo (IDE). Durante los ciclos iterativos de las diferentes fases de la propuesta de formación se aplicaron instrumentos como cuestionarios estandarizados, entrevistas y documentos para evidenciar el desarrollo de la propuesta. Mediante triangulación metodológica y de instrumentos se identifican las condiciones iniciales de los profesores participantes y su evolución durante la intervención. Se encuentra finalmente que los ciclos iterativos y las actividades que componen la unidad didáctica brinda herramientas didácticas, metodológicas y tecnológicas para mejorar las estrategias de diseño didáctico y la incorporación de TIC en propuestas para la enseñanza de la química a nivel de educación secundaria.
EL JUEGO CON PERSPECTIVA DE GÉNERO EN AULAS DE CIENCIAS: PERCEPCIONES DEL PROFESORADO EN FORMACIÓN INICIAL
Authors: Barria-Díaz Daniela , Amorín de Abreu Tamara , Arias-Correa Azucena , Álvarez-Lires María
Published: May 2023

Este estudio tiene como objetivo analizar las concepciones del profesorado en formación inicial, a través del conocimiento autopercibido, acerca del papel del juego en la enseñanza de las ciencias desde una perspectiva de género en una universidad latinoamericana. En la investigación se ha aplicado un formulario Knowledge and Prior Study Inventory, destinado a desvelar el conocimiento autopercibido, y se ha realizado un debate posterior. Los resultados mostraron un escaso conocimiento del significado de la perspectiva de género, una visión restringida de las posibilidades de uso del juego en los procesos de aprendizaje y enseñanza de las ciencias, así como concepciones sobre evaluación y rol del profesorado que apuntan a una visión tradicional de la enseñanza e indican la necesidad de realizar intervenciones destinadas a modificar dicha visión. Asimismo, se han detectado diferencias en percepciones y concepciones entre mujeres y hombres.
AGRONEGÓCIO E AMAZÔNIA: AÇÃO PEDAGÓGICA COMO AGIR COMUNICATIVO NA LEITURA INTEGRADA DE UM MUNDO COLONIZADO
Authors: Siqueira Ivone dos Santos , Raposo Elinete Oliveira , Freitas Nadia Magalhães da Silva
Published: May 2023

O agronegócio, passível de abordagem no ensino de ciências, é uma atividade econômica relacionada ao comércio de produtos agrícolas que se pauta pela lógica capitalista do lucro. Na Amazônia, vemos uma expansão da fronteira agrícola com a ocupação de terras e mudanças no uso do solo. No desvelamento dos passivos que advém desse empreendimento na Amazônia, conduzimos no contexto de uma pesquisa-formação, uma experiência de ação pedagógica no agir comunicativo, tendo o diálogo como fundamentadas interações na tematização do agronegócio. A pesquisa-formação, de natureza qualitativa, foi desenvolvida com estudantes da Licenciatura Integrada em Ciências, Matemática e Linguagens, da Universidade Federal do Pará, cuja estratégia metodológica da ação foi representada pelo painel integrado. A apreciação dos resultados da pesquisa (manifestações dos estudantes) foi pautada pela análise de conteúdo, precisamente pela técnica de análise de enunciação. Os resultados apontaram que a ação pedagógica comunicativa possibilitou aos estudantes perceberem ligações (in)visíveis dos distintos aspectos do agronegócio na Amazônia, logrando a superação da consciência ingênua, para uma consciência crítica, no desvelamento das contradições da realidade socioambiental da Amazônia, importantes para a educação em Ciências. A prática educativa, baseada no agir comunicativo, favoreceu a emancipação, o autoesclarecimento e o pensar de caminhos diferentes para transformar a realidade, plausível ao cenário social e ambiental da Amazônia. A ação educativa contra hegemônica suscitou posicionamentos contrários à colonização do mundo da vida. Certamente porque, nos negamos a agir numa perspectiva instrumental, a favor de uma racionalidade comunicativa.
VIAGEM AO CENTRO DA TERRA: REPRESENTAÇÃO DE CIÊNCIA NO LIVRO DE JULES VERNE
Authors: Leandro Davi Pacheco , Knöpker Mônica
Published: May 2023

A pesquisa que deu origem a este artigo objetivou analisar a representação de ciência disseminada pela pedagogia cultural posta em operação na obra Viagem ao centro da Terra, de Jules Verne. Essa obra aborda uma expedição, cheia de referências científicas, históricas e culturais, na qual o renomado professor Otto Lidenbrock e seu sobrinho Axel se enveredam até as entranhas do globo terrestre. Como aporte teórico-metodológico, tomamos como referência, em especial, proposições de Hall, Veiga-Neto, Andrade, Costa, Camozzato e Moura. Ademais, para analisar o material empírico, buscamos inspiração na produção foucaultiana sobre discurso e nas discussões a respeito da natureza da ciência realizadas por Peduzzi e Raicik. Os enunciados recorrentes presentes ao longo da narrativa, que propiciaram identificar como a ciência é representada na obra, foram organizados a partir de três perguntas: “O que é ciência?”, “Como se faz ciência?” e “Quem faz ciência?”. No que se refere à primeira pergunta, percebemos a existência dos enunciados a) a ciência é uma construção coletiva, b) a ciência é uma forma de se obter reconhecimento social e c) a ciência é produtora de verdades absolutas e imutáveis. No tocante à segunda pergunta, os enunciados recorrentes foram os seguintes: a) existe interesse pessoal e competição no fazer científico, b) a ciência parte de questionamentos e hipóteses e c) a ciência é posta à prova por meio da experimentação. No que concerne à terceira pergunta, identificamos os enunciados a) a ciência é executada por homens com características específicas e b) a ciência é realizada por sujeitos com personalidade egocêntrica. A partir da análise empreendida, concluímos que esses enunciados disseminam ensinamentos que nos orientam a compreender a ciência de uma determinada forma. E, partindo das discussões a respeito da natureza da ciência, ainda que exista enunciados bastante problemáticos na obra, é possível dizer que essa forma guarda algumas relações com as concepções contemporâneas a respeito do tema, mesmo que o livro tenha sido publicado pela primeira vez no ano de 1864.
Problem-Based Learning and Its Effects on Achievement and Attitude in Science Among Grade 8 Students
Authors: Caramay Camille S. , Ortega-Dela Cruz Ruth A.
Published: May 2023

The study used quasi-experimental research design to investigate the effects of problem-based learning (PBL) on the attitude and achievement in science among Grade 8 students in a public high school in the Philippines.  A problem-based learning module was developed using the ADDIE (Analysis, Design, Development, Implementation, Evaluation) model. It was used in teaching science. On the other hand, the Attitude Questionnaire in Science was adopted to describe the attitudes of students in both the control and experimental groups. Data were analysed through descriptive statistics. Prior to teaching science using PBL, the students showed different attitudes and had a low achievement in terms of mean percentage score. But after the implementation of PBL instruction, the students got positive attitude in science. They find the experience interesting and challenging at the same time. The PBL instruction in the experimental group caused a better understanding of topics in science than the lecture-based instruction. Given the results, the study recommended specific teaching techniques that will be useful in applying PBL to develop the students’ attitude and achievement in science especially in a blended-learning setup in this new normal.
Event risk management and online events practices, an example of a student organised event amid the Covid 19 pandemic
Authors: Xu Yueying Hazel , Tan Xiuchang Sherry
Published: May 2023

With the restrictions on traveling and gathering which have been employed in response to the Covid-19 pandemic, event planning and execution face all kinds of uncertainties, and contingency plans are an indispensable part in the planning process. While some events have been forced to postpone or cancel, a number of organisers have moved the events online or partly online. This case study uses a student-organised real event as an example to illustrate both the importance of risk management to success in event planning and execution under pandemic situations and how the risks have been identified and managed. The case also shares the practices for holding a dual-mode hybrid event.
Sustainability and sustainable event management
Authors: Mackay Clare , Julien Aurore , Hirst Jacob
Published: May 2023

Sustainability is a macro-level policy issue. It involves living and working in ways that do not negatively affect future generations. To operate sustainably, events organisers need to maximise positive – and mitigate negative – economic, socio-cultural, and environmental impacts and legacies. This case provides students with the opportunity to (a) identify the impacts and legacies of a music festival, (b) identify examples of good practice in sustainable events management and evaluate the extent to which they are impactful, (c) strategically plan how they will enhance the sustainability of a festival, and (d) how they will evaluate the success of their proposed initiatives.
Iravatham Mahadevan’s Reading of Indus Script: A Critical Review
Authors: C Jyothibabu
Published: May 2023

This paper comprehensively summarizes, analyses, and reviews Iravatham Mahadevan’s attempts to decipher the Indus script. Spanning a period of over thirty five years, Iravatham Mahadevan made continuous attempts to interpret and decipher the Indus script. Mahadevan claimed to have adapted the method of parallels between the symbolic representation and the text, between the written object and its designation, between the written symbol itself and its meaning, and the similarity throughout the ancient East of certain portions of the inscriptions, with the assumption that the underlying language of the script is Dravidian. Mahadevan was very flexible in changing his views and finding new interpretations, and gradually he shifted his interpretation of Indus signs from being phonetic/logographic/word to ideographic, leaving unshaken his core personal hypothesis and belief in the Veḷier clan and Tamil cultural settings. While Mahadevan did not succeed in making a self-consistent system of readings applicable to a large number of discovered pieces of writings, he did make a determined, persistent effort to develop a Dravidian framework for deciphering of the Indus script. This study seeks to find weaknesses in the methodology and assumptions of Mahadevan and searches for possible alternatives within that framework.
Ocrelizumab-induced Psoriasis in A Patient with Relapsing-Remitting Multiple Sclerosis
Authors: Esmaeili Sara , Zabeti Aram
Published: May 2023

Background: Ocrelizumab is widely used as a Disease Modifying Drug (DMD) in Multiple sclerosis. The complete side effects are yet not known.

Materials and Methods: We describe a 34-year-old female with longstanding relapsing-remitting Multiple Sclerosis for whom Ocrelizumab was started as an escalation therapy. She reported severe itchy and patchy lesions two months after the first full dose of Ocrelizumab. Pathohistological findings revealed the diagnosis of guttate psoriasis. Psoriasis continued to flare against treatment with topical steroids, and UV therapy and progressed to developed arthritis psoriasis.

Results: Treatment escalated to an IL-17 antagonist (Secukinumab), with a favorable outcome. Ocrelizumab was discontinued. After one year of follow-up, the patient remained stable from an MS standpoint.

Conclusion: This is the third report showing the possible cutaneous side effect of Ocrelizumab.
Saphenous sparing evolution
Authors: Ricci Stefano
Published: May 2023

While Saphenous stripping became the gold standard technique for varicose veins treatment in the second part of last century, soon, leaving the Saphenous stem in place for surgical simplification and, successively, for arterial bypass use became a subject of research, showing uncertain responses. Ultrasound facilities allowed better hemodynamic knowledge; a new hemodynamic approach (CHIVA) appeared that limited venous ablation and redirected the blood to the deep system normalizing the pressures, allowing Great Saphenous Vein preservation. Even new technologic evolutions (thermal, chemical), created for venous ablation, could be converged toward this conservatory attitude simply changing the mental scheme.
The painting of Mauro Bartolo: ‘Pietas for the saphenous veins’, too many saphenous ablations in the days of academic stripping
Authors: Calandra Giuseppe
Published: May 2023

Prof. Bartolo, significant figure of Italian Angiology during the last decades of the XX century and founder of a Roman School of Angiology, was always sceptic about the surgical treatment of varicose veins.
The modalities of stripping and its results were not a satisfactory surgical solution of the disease, from a clinical, aesthetic, social and finally economic point of view.
Prof. Bartolo preferred conservative treatment in most cases, suggesting to give more space to minimally invasive treatments such as CHIVA, phlebectomy, sclerotherapy with the aim of achieving saphenous sparing and thus paving the way to the cultural foundation of modern phlebology.
The current paper contains the translation and reprint of an Editorial of Prof. Bartolo about saphenous sparing treatments.
College Student's Perception toward " Peduli Lindungi" Application through the Usability Scale Method
Authors: Yogananti Auria F , Ihya' Ulumuddin Dimas Irawan
Published: May 2023

The Covid-19 pandemic that occurred in Indonesia had an impact on various sectors such as education, health, and the economy. These impacts provide enormous losses for the community as well as the government. The government has issued many policy instruments to suppress the impact caused by the Covid-19 pandemic. One of the policies made by the government as a form of dealing with the Covid-19 pandemic is to create an application that functions as a tool for tracking people's movements. This government-made Application is called the Peduli Lindungi application [3]. The Ministry of Communication and Informatics develops the Peduli Lindungi application, the Ministry of Health, the Ministry of SOEs, and the National Disaster Management Agency (BNPB). At first, the Care for Protect application was named TraceTogether. The Peduli Lindungi application's primary function is to digitally detect and identify location data and community information in supervising the handling of Covid-19 [4]. This Peduli Lindungi application is used at almost all levels of Indonesian society, including students. Students who incidentally are the generation who are familiar with the Application are expected to be able to use the Care Protect application quickly. Still, it is necessary to measure the feasibility of the system to find out students' views on the feasibility of the existing system in the Care Protect application. This study uses quantitative methods with data analysis tools using the System Usability Scale (SUS) method. Of the 73 respondents who took part in the survey, all of whom are application users and students, it is known that the usability of the Peduli Lindungiapplication in the eyes of students is still not good.
Penerapan pendidikan karakter melalui pendidikan ips di SD 05 Baringin
Authors: Arisma Nuria Arisma
Published: May 2023

Abstract

The purpose of this study is to describe the implementation of character education in the social studies education of SDNI05 BaringinIand to explore the facilitators and hindrances in the process of character building of students. This research is qualitative research. The results are as follows: (1) Character education is carried out through curricular activities and extracurricular activities. (2) Implement character education and social studies instruction in learning spaces from teacher preparation to classroom conditioning including arriving at school on time to shake hands and I recite the Quran. including opening and closing classes. (3) Most sociology teachers adopt the classroom teaching method in character education teaching which does not maximize students' iresponseItoIthe implementation of character education. I(4) Factors conducive to the implementation of character education in which the principles taught in every classroom Capcentrian values ​​of school culture and the support and foundation of principals and teachers.
Penerapan Metode Diskusi Untuk Meningkatkan Hasil Belajar di SD Muhammadiyah 01 Babat
Authors: Almaida Sarah Almaida , Khusnia Putri Septya , Rahmat Prayogo Andy , Apmad Ipvmawan Kharisma Apmad , Apmad Ipvmawan Kharisma Apmad
Published: May 2023

The research carried out was Classroom Action Research. The purpose of conducting this classroom action research is to improve and improve the practice that should be done by the teacher. The average score of learning outcomes in the initial reflection I reached 68.39 Of the 31 students in the high school class of SDM 01 Babat students were able to achieve scores in accordance with the KKM. Thus classical completeness was only achieved as much as 54.84%. Referring to these results, the average learning outcomes, absorption and classical learning completeness have not met the predetermined targets. Therefore, learning outcomes can be improved through the application of the discussion method in the learning process. Because the observation results of cycle 1 and cycle 2 can state that the discussion method can improve learning outcomes in students of SDM 01 Babat. Because of the increase in reflection in cycle II by 70% with an average student learning outcome of 81.29 so that it can be said to be successful.
Efektivitas Pola Belajar Visual Auditory Kinestetik (VAK) untuk Meningkatkan Kemampuan Terjemahan Al-Quran bagi Anak Berkesulitan Belajar
Authors: Zulmiyetri Zulmiyetri
Published: May 2023

Penelitian ini dilatar belakangi oleh permasalahan yang peneliti temukan di SDN 09 Koto Lua pada kelas III berjumlah lima orang siswa berkesulitan belajar. Hal ini terbukti dari hasil pengamatan yang peneliti lakukan. Penelitian ini bertujuan untuk mengetahui sejauh mana efektivitas pola belajar visual auditori kinestetik (VAK) untuk meningkatkan kemampuan terjemahan Al-quran bagi anak berkesulitan belajar. Metode penelitian menggunakan pendekatan kuantitatif dengan desain penelitiannya adalah preexperimental design dengan one group pretest and postest pre eksperiment. Teknik pengumpulan data yang digunakan adalah tes, dan alat pengumpul data yang digunakan adalah penggalan ayat dari surat al-qoriah. Hasil penelitian dianalisis menggunakan uji Mann Whitney . Dengan kriteria pengujian penilaian penelitian ini adalah: hipotesis diterima jika Uhit > Utab pada taraf signifikan 95% atau α = 0,05. Diluar kondisi ini hipotesis ditolak. Hasil penelitian menunjukkan bahwa nilai rata- rata posttest siswa meningkat dari hasil pretest setelah dilakukan treatment sebanyak lima kali. Kemampuan siswa dalam menterjemahkan al-quran meningkat setelah diterapkan metode VAK. Berdasarkan hasil penelitian tersebut disimpulkan bahwa pola belajar visual auditori kinestetik (VAK) efektif digunakan untuk meningkatkan kemampuan terjemahan al-quran bagi anak berkesulitan belajar.
Kebutuhan Bahan Ajar Digital Berbasis Studi Kasus di Perguruan Tinggi; Upaya Implementasi Merdeka Belajar
Authors: Syafril Syafril , Rahmi Ulfia
Published: May 2023

Tujuan penelitian ini adalah mengidentifikasi kebutuhan bahan ajar digital berbasis studi kasus di perguruan tinggi sebagai upaya untuk mengimplementasikan merdeka belajar di Indonesia. Kemampuan analisa kasus yang dilakukan dapat membantu meningkatkan keterampilan berpikir mahasiswa untuk mencapai kemerdekaan berpikir. Penelitian dilakukan pada mata kuliah Dasar-dasar Imu Pendidikan sebagai mata kuliah wajib di Perguruan Tinggi Lembaga Penghasil Tenaga Kependidikan (LPTK). Bahan ajar telah tersedia dalam bentuk cetak dan digital namun bagaimana kebutuhan bahan ajar yang berbasis studi kasus? Penelitian ini dilakukan dengan mix metode. Mahasiswa yang telah mengikuti mata kuliah Dasar-dasar Ilmu Pendidikan dimintai mengisi angket dan diwawancarai terkait kebutuhan terhadap bahan ajar berbasis studi kasus. Data tersebut dianalisis teknik analisis data deskriptif dan triangulasi data. Hasil dari penelitian menunjukkan bahwa mahasiswa membutuhkan bahan ajar digital berbasis studi kasus. Bahan ajar berbasis studi kasus ini direkomendasikan juga untuk dikembangkan pada mata kuliah lain sebagai upaya mencapai kemerdekaan berpikir.
MENJAWAB KEBUTUHAN PEKERJA MIGRAN INDONESIA BERKETERAMPILAN BAHASA INGGRIS SEBAGAI BAHASA GLOBAL
Authors: Perangin-Angin Dalan Mehuli , Manggala Simon A. , Fitriati Anna , Putranti Adventina , Rosiandani Ni Luh Putu , Puri Anindita D. , Pukan Elisabeth O.
Published: May 2023

This paper aims to discuss the reasons and solutions why and how Indonesian Migrant Workers (IMWs), need to increase their English proficiency. We use a sociolinguistic approach to understanding the phenomenon of English as a Global Language including its history, social functions, prestige, and why its speakers gain better social status in society. Furthermore, we discuss the data we gained from dispersing questionnaires for need analysis in google forms to some networks of Indonesian in Hong Kong (59 correspondents). The data doubtlessly show they want to enhance their English mastery and intend to join our free online English course program. In the second year of the program (2022), we become more convinced in conducting the program for a longer run in the future, as unexpectedly the number of IMWs who want to join the course has raised four times (about three hundred from the expected ninety participants only), and have gained supports from various institutions such as the Consulate General of the Republic of Indonesian in Hong Kong and Macau, and Indonesian Diaspora Network Global. As an academic institution, we are assured that the present program will be a valuable contribution for society, especially the IMWs.