bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling Cost-Effectiveness of Syphilis Detection Strategies in Prisoners: Exploratory Exercise in a Chilean Male Prison
Authors: Castillo-Laborde Carla , Gajardo Pedro , Ferrari Manuel Nájera-De , Matute Isabel , Hirmas-Adauy Macarena , Aguirre Pablo , Ramírez Héctor , Rámirez Daniel , Aguilera Ximena
Published: January 2021

BACKGROUND: Syphilis, together with other sexually transmitted infections, remains a global public health problem that is far from controlled. People deprived of liberty are a vulnerable population. Control activities in prisons rely mostly on passive case detection, despite the existence of affordable alternatives that would allow switching to active case-finding strategies. Our objective was to develop a mathematical modelling framework for cost-effectiveness evaluation, from a health system perspective, of different approaches using rapid tests for the detection of syphilis in inmates' populations and to explore the results based on a Chilean male prison population. Methods: A compartmental model was developed to characterize the transmission dynamics of syphilis inside a prison with the ongoing strategy (passive case detection, with VRDL + FTA-ABS), considering the entrance and exit of inmates over a 40 year period. The model allows simulation of the implementation of a reverse algorithm for the current situation (rapid test + VDRL), different screening strategies (entry point, massive periodically; both with rapid test + VDRL) and treatment of detected cases. The parameters for the exploratory exercise were obtained from systematic searches of indexed and grey literature and field work (EQ-5D questionnaire application and key actors interviews). Probabilistic sensitivity analysis was conducted to account for uncertainty in relevant parameters. RESULTS: The proposed framework allows the evaluation of different detection strategies. In this study, all the strategies were cost-effective in the baseline scenario when considering an ICER threshold of 1 Chilean GDP per capita (US$15,000). The strategies most likely to be cost-effective (over 80% probability) were: current situation with reverse algorithm, entry point screening and mass screening every two years; the latter was the most effective, achieving the lowest prevalence (0.7% and 1.7% over the period versus the 3% prevalence in the current situation).CONCLUSIONS: Mathematical modelling that considers the performance of different tests and detection strategies could be a useful tool for decision making. The exploratory results show the efficiency of adopting both the use of the rapid tests and performing active case detection to significantly reduce the burden of syphilis in Chilean prisons in the near future.
Forecasting the effectiveness of the DeWorm3 trial in interrupting the transmission of soil-transmitted helminths in three study sites in Benin, India and Malawi
Authors: Truscott James , Hardwick Robert J , Werkman Marleen , Saravanakumar Puthupalayam Kaliappan , Manuel Malathi , ajjampur Sitara S R , Asbjornsdottir Kristjana H , Khumbo Kalua , Witek-McManus Stefan , Simwanza James , Cottrell Gilles , Houngbégnon Parfait , Ibikounlé Moudachirou , Walson Judd L , Anderson Roy M
Published: January 2021

Background The DeWorm3 project is an ongoing cluster-randomised trial assessing the feasibility of interrupting the transmission of soil-transmitted helminths (STH) through mass drug administration (MDA) using study sites in India, Malawi and Benin. In this paper, we describe an approach which uses a combination of statistical and mathematical methods to forecast the outcome of the trial with respect to its stated goal of reducing the prevalence of infection to below 2%. Methods Our approach is firstly to define the local patterns of transmission within each study site, which is achieved by statistical inference of key epidemiological parameters using the baseline epidemiological measures of age-related prevalence and intensity of STH infection which have been collected by the DeWorm3 trials team. We use these inferred parameters to calibrate an individual-based stochastic simulation of the trial at the cluster and study site level which is subsequently run to forecast the future prevalence of STH infections. The simulator takes into account both the uncertainties in parameter estimation and the variability inherent in epidemiological and demographic processes in the simulator. We interpret the forecast results from our simulation with reference to the stated goal of the DeWorm3 trial, to achieve a target of ≤ 2% prevalence at a point 24 months post-cessation of MDA. Results Simulated output predicts that the two arms will be distinguishable from each other in all three country sites at the study endpoint. In India and Malawi, measured prevalence in the intervention arm is below the threshold with a high probability (90% and 95%, respectively), but that in Benin the heterogeneity between clusters prevents the arm prevalence being reduced below the threshold value. At the level of individual study arms within each site, heterogeneity among clusters leads to a very low probability of achieving complete elimination in an intervention arm, yielding a post-study scenario with widespread elimination but a few `hot spot' areas of persisting STH transmission.Conclusions Our results suggest that geographical heterogeneities in transmission intensity and worm aggregation have a large impact on the effect of MDA. It is important to accurately assessing cluster-level, or even smaller scale, heterogeneities in factors which influence transmission and aggregation for a clearer perspective on projecting the outcomes of MDA control of STH and other neglected tropical diseases.
Association between renal function and platelet reactivity during aspirin therapy in elderly patients with atherosclerotic cardiovascular disease
Authors: Liang Wenyi , Zhang Peng , Liu Meilin
Published: January 2021

Background: Aspirin is the key treatment in the secondary prevention of atherosclerotic cardiovascular disease. High on-treatment platelet reactivity (HTPR) to aspirin has been reported to partially account for the enhanced risk of thrombotic events. In particular, HTPR has been described more frequently among elderly patients. The aim of this study was to identify the clinical and biological factors associated with HTPR in a real-life elderly population.Methods: In this retrospective study, elderly patients with atherosclerotic cardiovascular disease on regular aspirin treatment were enrolled. Cardiovascular risk factors, routine biological parameters, comorbidities, and concomitant medications were recorded. The upper quartile of the platelet aggregation rate, determined by light transmission aggregometry with arachidonic acid, was defined as the HTPR group.Results: A total of 304 patients were included (mean age 77 ± 8 years, 76% men). Patients in the HTPR group were older than the patients in the non-HTPR group (mean age: 79 ± 7 vs. 76 ± 8 years, p = 0.008). Patients with moderately decreased estimated glomerular filtration rate (eGFR) had a higher frequency of HTPR than patients with slightly decreased eGFR or normal eGFR (35.8%, 22.5%, 12.2%, respectively, p < 0.05). In multivariate analysis, an independent risk factor for HTPR was the eGFR (OR: 0.984, 95% CI: 0.980-0.988, p < 0.001).Conclusions: Advanced age and decreased eGFR are correlated with poor pharmacodynamic response to aspirin.
Steganography algorithm based on modified EMD coded PU partition modes for HEVC videos
Authors: Zhang Zhenzhen , Li Zhaohong , Liu Jindou , Yan Huanma , Yu Lifang
Published: January 2021

As High Efficiency Video Coding (HEVC) is a worldwide popular video coding standard, the steganography of HEVC videos has gained more and more attention. Prediction Unit (PU) is one of the most important innovative modules of HEVC, thus PU partition mode based steganography is becoming a novel branch of HEVC steganography. However, the embedding capacity of this kind of steganography is limited by the types of PU partition modes. To solve the problem, modified Exploiting Modification Direction (EMD) coded PU partition modes based steganography is proposed in this paper, which can hide a secret digit in a ( [[EQUATION]] )-ary notational system in a pair of PU partition modes and thus enlarging the capacity. Furthermore, two mapping patterns for PU partition modes are analyzed and the one that performs the better is selected as the final mapping pattern. Firstly, 8×8 and 16×16 sized PU partition modes are recorded according to the optimal mapping pattern in the video encoding process. Then PU partition modes are modified by using the proposed method to satisfy the requirement of secret information. Finally, the stego video can be obtained by re-encoding the video with the modified PU partition modes. Experimental results show that the embedding capacity can be significantly enlarged, and compared with the state-of-the-art work, the proposed method has much larger capacity while keeping high visual quality.
Determination of the role of polymorphic variants of the interferon-gamma gene (IFNG) in the development of tuberculosis in the Yakut population
Authors: Mordovskaya L. I. , Egorova M. V. , Klimova T. M. , Аlekseeva S. D.
Published: January 2021

The objective of the study: to determine the role of polymorphic variants T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the development of tuberculosis in the population of Yakut nationality.

Subjects and methods. The case-control study was conducted. The subject for the study was DNA samples from 172 tuberculosis patients (the case group) and 367 people with an excluded diagnosis of tuberculosis (the control group). All participants of the study belonged to Yakut nationality. For genotyping, DNA was isolated from venous blood. The genotyping was performed by real-time polymerase chain reaction. For statistical processing, Pearson's χ2 test and odds ratio with 95% confidence intervals were used.

The results of the study showed that the distribution of genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the case and control groups corresponded to the Hardy – Weinberg equilibrium. There was no statistically significant difference in frequencies of alleles and genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the patients from the case and control groups.

Conclusions. The results of the study did not reveal the association of alleles and genotypes of the rs2430561 and rs2069718 polymorphic variants of the IFNG gene with the risk of developing tuberculosis for people of Yakut nationality.
ACREDITAÇÃO HOSPITALAR COMO FERRAMENTA PARA A GESTÃO DA QUALIDADE NO BRASIL: CARACTERÍSTICAS, AVANÇOS E DESAFIOS
Authors: MATIAS DO NASCIMENTO JULIO CESAR
Published: January 2021

Resumo: A acreditação é um metodo para a excelência em gestão e assistência em saúde. Objetivou-se, por meio de uma revisão integrativa da literatura, identificar características e avanços da acreditação nos hospitais brasileiros e as dificuldades do serviço de gestão da qualidade. Foram rastreados 702 estudos nas bases de dados eletrônicas, que após elegibilidade considerou-se 08 artigos para esta revisão, publicados entre 2011-2018. A rede privada representou 65% dos locais de estudo e a Organização Nacional de Acreditação foi a principal certificadora (75%). Os enfermeiros realizaram 75% dos estudos, sendo relevantes na gestão da qualidade. Os hospitais buscam na acreditação aprimorar a gestão e a segurança do paciente, aumentar a produção e a competição no mercado. É primordial sensibilizar colaboradores, manter comunicação eficiente e valorizar o profissional. Há dificuldades com a mudança da cultura organizacional e a rotatividade de funcionários. A acreditação promoveu a satisfação e o reconhecimento profissional, a padronização de processos, a consolidação de programas de educação, a segurança do paciente e a avaliação contínua dos serviços e desempenho profissional.

 

Palavras-chave: Acreditação hospitalar; Gestão da qualidade; Gestão em saúde.
GROSSESSE GEMELLAIRE ASSOCIANT UNE MOLE COMPLETE ET UNE GROSSESSE SINGLETON NORMALE: A PROPOS DUN CAS
Authors:   Service Gynecologie-Obstetrique 1 CHU Hassan II, Fes, Maroc., El Hilali Fouzia , Achkif Salahedine ,   Service Gynecologie-Obstetrique 1 CHU Hassan II, Fes, Maroc., Erraghay Sanaa ,   Service Gynecologie-Obstetrique 1 CHU Hassan II, Fes, Maroc., Karam Saoud Mohamed ,   Service Gynecologie-Obstetrique 1 CHU Hassan II, Fes, Maroc., Mamouni Nissrine ,   Service Gynecologie-Obstetrique 1 CHU Hassan II, Fes, Maroc., Bouchikhi Chahrazad ,   Service Gynecologie-Obstetrique 1 CHU Hassan II, Fes, Maroc., a Abdelazizbanani ,   Service Gynecologie-Obstetrique 1 CHU Hassan II, Fes, Maroc.
Published: January 2021

Twin pregnancy involving a complete mole and a normal singleton pregnancy with its own healthy trophoblast is a rare entity. The most serious complication is the progression to gestational trophoblastic disease. Reporting the case of a 38-year-old pastry, G5P4, consultant for bleeding after pregnancy of 16 weeks not followed, whose pelvic ultrasound showed the appearance of an association of a complete hydatidiform mole and a normal singleton pregnancy .The patient had a spontaneous abortion 48 hours after her hospitalization. The anathomopathologic study confirmed the diagnosis of the association of a complete mole and a normal placenta. The evolution is marked by the non-evolution towards gestational trophoblastic disease. ï»¿
The relationship of risk factors and heart remodeling in patients with metabolic syndrome and arterial hypertension
Authors: Polozova E. L. , Puzanova E. V. , Seskina A. A. , Nefedov N. S.
Published: January 2021

Introduction. Arterial hypertension (AH) is a widespread disease in the population of the world. It also acts as one of the constituent components of metabolic syndrome (MS), which is a global “epidemic” of our time. Target organs in such patients are affected much earlier and their changes are more pronounced than in hypertensive patients without metabolic disorders. It is important to study the contribution of risk factors to the progression of cardiac dysfunction in this category of patients.

Purpose of the study. To study the influence of risk factors on heart remodeling in patients with hypertension, burdened and not burdened by metabolic disorders, selected for clinical analysis from the cardiology department of the Republican Clinical Hospital № 4, Saransk in 2016-2019.

Materials and methods. For clinical analysis, 139 patients were selected from the cardiology department of the Republican Clinical Hospital No. 4, Saransk. Depending on the presence of metabolic disorders, the following groups were identified: Group I (n = 72) – patients with MS and AH; Group II (n = 67) – AH patients without metabolic disorders. The study evaluated the morphological and functional state of the myocardium and risk factors in the analyzed groups.

Results. In the group of patients with hypertension, aggravated by metabolic disorders, more pronounced processes of cardiac remodeling were revealed. It has been shown that patients with MS develop both eccentric and concentric models of left ventricular hypertrophy. The influence of the level of blood pressure and body mass index is differently reflected on the type of restructuring of the geometry of the myocardium. Patients with hypertension combined with metabolic disorders have a wider prevalence of risk factors. The burden of risk factors is higher in patients with concentric left ventricular hypertrophy and MS.

Conclusions. The role of metabolic disorders in the mechanism of cardiac remodeling development in patients with hypertension in combination with MS was determined.
How the Visions Genre Correlates in the Protestant and Orthodox Christian Culture of the Nineteenth Century: a Theological and Philosophical Analysis
Authors: Laluev Vladimir
Published: January 2021

The increasing interest of the mass audience to various types of fantasy art triggered an interest for the genre of religious vision, a phenomenon of the theological literature of the XIX century. The present research featured a philosophical and theological analysis of the genre of vision in the Western European and Russian religious culture of the XIX century. The research objective was to identify the origins of the genre of vision that arose in the religious culture of the XIX century and to give it a general description. The author compared the visionary experiences of the Protestant author Ellen G. White and an anonymous Orthodox author. The study helped to reveal that people's idea of the existence of the other world is an integral component of the imaginary world that underlies any religion and can be a subject of comprehensive analysis in modern theology and cultural studies. The author used the following research methods to comprehend the spiritual experiences embodied in the genre of visions and recorded in the doctrinal literature of Protestantism and Orthodoxy: the comparative historical method and the textual analysis of visionary texts, theological literature, and ontopsychological studies. The theoretical basis included various works by Russian philosophers, cultural scholars, and theologists, who elevated the visionary literature to the level of meta-scientific synthesis. The scientific novelty of the research is that it compares the spiritual experiences of Protestantism and Orthodoxy. The paper introduces a method that can be used to study other religious confessions in philosophical and religious discourse.
Ontological Aspects of Power in Western European Discourse
Authors: Yazsevich Maria
Published: January 2021

The article explores the ontological foundations of power in Western European philosophical discourse. The author analyzed essential characteristics of power within classical and non-classical paradigms, thus revealing the relationship of its ontological principles with social practice in different historical periods. According to the classical rationalistic world view, power was endowed with metaphysical properties, which provided it with transcendental status and ethical characteristics. Power correlated with such concepts as "good", "hierarchy", "responsibility", "order", "law", "justice", etc. This discourse presented the government as a category of ontological order, sacrament to the Absolute, and contributed to the development of its institutional forms and management strategies based on control, subordination, and coercion. The non-classical paradigm put forward the idea of power as a manifestation of the irrationality of the human psyche. Criticism of logo-centrism made voluntaristic philosophers present power as a category of anthropological discourse. Its basic properties were defined through such concepts as "universality", "irrationality", "subjectivity", "totality", "ubiquity", etc. Power was deprived of its transcendental status and ethical character, which traditionally provided it with legitimacy in society. However, it acquired the properties of universality and immanence of human nature in the unconscious structures of human psyche. In social practice, the transformation of the principles of power led to the development of ideological discourses and new ways of exercising power
The Synthesis of a Critical Infrastructure Object Model for Safe Operation of a Technical System Under the Conditions of Destructive Information Impact
Authors:   The educational center ", Kubarev Aleksey ,   Echelon", Lapsar’ Aleksey ,   The Department of the FSTEK of Russia for the Southern and North Caucasian Federal Districts, Asyutikov Alexander ,   National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Published: January 2021

The purpose of the article: improving the security and stability of the functioning of complex technical systems managed by critical information infrastructure objects under the conditions of a destructive information impact, using parameterized evolutionary models. Methods: synthesis of parametrized evolutionary models of significant objects of critical information infrastructure based on the Markov theory of estimation of multidimensional diffusion processes. The result: within the framework of an integrated approach to ensuring the security of complex technical systems, a parametrized evolutionary model of an object of a critical information infrastructure operating under conditions of destructive information impact has been synthesized. An approach to the development of recommendations for managing a complex technical system by means of an operational assessment of the main characteristics of the functioning of a critical information infrastructure object is proposed. A sequence has been developed for developing solutions for the operation of a complex technical system, based on an assessment of the impact level and the results of an operational calculation of the main characteristics of the functioning of a critical information infrastructure object. The results obtained make it possible to reasonably formulate technical requirements for the created or modernized means of ensuring the security of significant objects of critical information infrastructure that manage complex technical systems.
New Elements of National Security: National and International Aspects
Authors:   Gubkin Russian State University of Oil and Gas (National Research University), Kartskhiya Alexander
Published: January 2021

The purpose of the study is to study the legal aspects of the structural development of national security to identify trends and factors that influence the formation of national interests of an individual state and international relations, as well as to study the national security system from a legal standpoint. The method of research: a comparatively legal comparison and analysis of current national Russian and foreign legislation and development strategies, international treaties and agreements on national security issues and their application. Result: The study revealed objective prerequisites for the formation of new independent elements of the Russian Federation’s national security system, including biosecurity, cybersecurity, cryptosecurity and investment security. These new elements form their own subjects and ways of ensuring national interests and national security in these areas, have their own legislative framework and legal regulation, which clearly determines the need to allocate them into independent structural elements of national security for further legislative regulation and practical implementation in terms of protecting national interests.
Therapeutic Agents Against COVID-19 with Clinical Evidence
Authors: Tian Cheng , Xiang Ming
Published: January 2021

Over 57 million people have been confirmed to have coronavirus disease 2019 (COVID-19) worldwide. Although several drugs have shown potential therapeutic effects, there is no specific drug against COVID-19. In this review, we summarized potential therapeutic agents against COVID-19 with clinical evidence, including antiviral agents, anti-cytokine storm syndrome agents, and vaccines, as well as other drugs. In addition, we briefly discussed their effects on COVID-19, which will contribute to developing treatment plans.
Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy
Authors: Lou Xue-Fang , Du Yong-Zhong , Xu Xiao-Ling
Published: January 2021

The emergency of responsive drug delivery systems has contributed to reduced cytotoxicity,
improved permeability in tissues and extended circulation time of the active drug. In particular,
enzyme-responsive nanoplatforms have attracted a lot of attention due to the specificity and
efficiency of an enzyme-catalyzed reaction. In this review, enzyme-based mono responsive drug delivery
systems designed in the past 5 years have been summarized. These drug delivery systems
were introduced by different tumor-related enzymes such as matrix metalloproteinase, esterase,
hyaluronidase, caspase and cathepsin. Moreover, the enzyme-sensitive nanoplatforms activated by
dual-stimuli have been also described. Although great progress had been made in the past years,
the translation into clinical practice is still difficult. Thus, three obstacles (enzyme heterogeneity, reaction
environment, animal model) were also discussed. In short, enzyme-activated drug delivery
systems offer great potential in treating cancers.
SET Protein in Cancer: A Potential Therapeutic Target
Authors: Liang Xinjie , Bao Xuefei , Chen Guoliang
Published: January 2021

SET protein is a multi-functional oncoprotein that is ubiquitously expressed in most tumor
cells. Dysregulation of SET has been associated with many types of cancer. Due to ever-accumulating
evidence of its strong correlation with both poor prognosis and drug resistance, the targeting of SET is
starting to be explored. SET is currently regarded as a potential target for cancer therapy, and several
inhibitors are being developed for clinical trials. In this review, the physiological and pathological
functions of SET, as well as its antagonists, will be discussed along with the prospects and challenges
involved with translating SET inhibitors into bona fide therapeutic options.
Highlighting Aglycone-dependent Glycosylation Aspects in Caryophyllaceae Saponins by a Simplex Simulation Approach
Authors: Hammami Asma , Farman Muhammad , Semmar Nabil
Published: January 2021

Background:

Saponin metabolism shows high structural variability due to the diversity
of aglycones and glycosylations (Gly). Although they represent a potential source of drug design,
their metabolism remains misunderstood yet due to insufficient investments in analytical methods.

Aims:

Bibliographic structural data offer a wide field for extensive statistical analysis, highlighting
mechanistic orders governing metabolic diversity. This work presents an original simulation
method based on simplex rule for highlighting regulatory mechanisms of metabolism from categorical
structural data.

Methods:

Simulation was applied on a set of 231 saponins of the Caryophyllaceae plant family initially
affiliated to four aglycone types: gypsogenin (Gyp), quillaic acid (QA), gypsogenic acid
(GA), and 16-OH-gypsogenic acid (16-OH-GA). Molecules were initially characterized by relative
glycosylation levels of different carbons. Simplex approach was applied by combining saponins of
the four aglycone groups using a complete set of N gradual weightings between structural groups.
In silico combinations were applied by randomly sampling representative saponins from the four
groups conforming to their weights given by mixture design. Gly profiles of sampled saponins
were averaged to calculate a barycentric molecular profile for each mixture. With N mixtures, N
barycentric molecules were iteratively calculated by bootstrap, leading to smoothed data from
which Gly trends between carbons were highlighted.

Results:

Sequential, competing and cooperative Gly trends were highlighted according to the types
of aglycones, attached saccharides and positions of substituted carbons. Such various conditional
Gly trends seemed to be linked to multiple factors, including steric effects, regio-selectivity, enzymatic
specificity and enzymatic promiscuity. These simulated results could be helpfully useful in
chemical synthesis and drug design.

Conclusion:

These simulated results could usefully help for chemical syntheses and drug design.
Proteomic Technologies and their Application for Ensuring Meat Quality, Safety and Authenticity
Authors: Banerjee Rituparna , Maheswarappa Naveena Basappa , Mohan Kiran , Biswas Subhasish , Batabyal Subhasish
Published: January 2021

:

Proteomic tools were extensively used to understand the relationship between muscle proteome and conversion of muscle to meat, post-mortem proteolysis, meat texture, and variation in meat color. Developments in proteomic tools have also resulted in their application for addressing the safety and authenticity issues including meat species identification, detection of animal byproducts, non-meat ingredients and tissues in meat products, traceability, identification of genetically modified ingredients, chemical residues and other harmful substances. Proteomic tools are also being used in some of the potential areas like understanding the effect of animal transportation, stunning, slaughter stress, halal authentication and issues related to animal welfare. Emerging advances in proteomic and peptidomic technologies and their application in traceability, meat microbiology, safety and authentication are taking a major stride as an interesting and complementary alternative to DNA-based methods currently in use. Future research in meat science need to be linked to emerging metabolomic, lipidomic and other omic technologies for ensuring integrated meat quality and safety management. In this paper, a comprehensive overview of the use of proteomics for the assessment of quality and safety in the meat value chain and their potential application is discussed.
Facile Synthetic Protocols for the Preparation of New Impurities in Pemetrexed
Disodium Heptahydrate as an Anti-cancer Drug
Authors: Jaggavarapu Rama Mohana Reddy , Muvvala Venkatanarayana , Ghojala Venkatareddy , Babu H. Sharath , Cheedarala Ravi Kumar
Published: January 2021

A facile synthetic protocol was employed to prepare process-related impurities associated with the
synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of
the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and
N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis, such as
1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for quality control.
Computational Bioactivity Analysis and Bioisosteric Investigation of the Approved Breast Cancer Drugs Proposed New Design Drug Compounds: Increased Bioactivity Coming with Silicon and Boron
Authors: Dogan Esma Eryilmaz
Published: January 2021

Background:

The breast cancer takes the first place among women cancer diagnosed
worldwide.

Objective:

Based on the preferential multi-targeted approach on cancer therapy, we, in this study, aimed to design in silico
drug candidates possessing multi-targeted bioactivity to cope with multi-drug resistance using the known drug structures,
molecular modeling, and ADME parameters.

Materials and Methods:

We first evaluated the bioactivity score of the approved breast cancer drugs
across the top-three drug targets GPCR, kinase, and nuclear receptors and calculated their
physicochemical properties to see their drug-likeness profiles. Among 29 approved drugs, Aromasin
and Capecitabine showed the broadest bioactivity across the targets listed. By using molecular
modeling and bioisosteric modifications, and applying two filtering approaches, we investigated
thirty-one analogues of Aromasin and Capecitabine.

Results :

Software prediction resulted in that the compounds A14, C4, and C13 replaced with
B(OH)2 and/or Si(CH3)3 showed a broader spectrum of biological activity with a multi-targeted
manner than even the approved analogs.

Conclusion:

The interesting point of these new design molecules is to have either silicon and/or
boron incorporation. The increased bioactivity effect of Silicon and Boron incorporation is also seen
in the recently approved drug list of FDA and in clinical trials ongoing. Our new design boron and
silicon-based molecules appeared to be promising candidates for breast cancer treatment to be tested
in vitro, in vivo, and in the clinic for further pharmacological investigations.
Use of Paediatric Xylometazoline Nasal Drop is not a Child’s Play in Hypertensive Patients on Bisoprolol: A Case Report
Authors: Bhalla Hira , Gupta Abhishek , Patel Tejas
Published: January 2021

Background:

Xylometazoline, a sympathomimetic agent, is considered safe in hypertensive
patients as a relief measure for nasal congestion with intranasal application.

Case Report::

In the present case, a 58-year old male patient, having ischemic heart disease, controlled
hypertension on telmisartan and bisoprolol, experienced hypertensive urgency in a span of
two hours of intranasal administration of the paediatric formulation of xylometazoline.

Conclusion:

The interaction with bisoprolol should be kept in mind while using xylometazoline.
Photochromic Core-shell Nanoparticles
Authors: Barachevsky V.A.
Published: January 2021

The results of spectral-kinetic studies in the field of nanophotochromism of the core‒
shell type hybrid compounds are integrated. The properties of photochromic nanoparticles based
on photochromic spirocompounds (spiropyrans and spirooxazines), chromenes, and diarylethenes
and nanoparticles of noble metals (Ag and Au), diamonds, graphene and its oxide, silica, fullerenes,
and quantum dots are considered. Preparation methods of photochromic nanoparticles have
been developed.
SUBJECTS OF STATE CONTROL AND SURVEILLANCE ACTIVITY IN HOUSING AND COMMUNAL SERVICES AND THEIR COMPETENCE
Authors:   A.Z. Arslanbekova Dagestan State University, Arslanbekova A.Z. , Mursalov F.A. ,   F.A. Mursalov Dagestan State University
Published: January 2021

The article reveals the actual problems of state control and supervision in housing and communal services. Organizational shortcomings and systemic contradictions arising in the activities of state housing supervision bodies are considered. The authors touched upon the gaps and shortcomings of legislation in the sphere of state regulation and management of housing and communal services. The article reveals certain aspects of the structure of state bodies in the housing and utilities sector and related industries that can lead to conflicts of interest in the implementation of various Supervisory functions. In conclusion, it is concluded that the state housing supervision and licensing control in the subjects of the Russian Federation has a number of organizational shortcomings and gaps in the regulatory legal support for the activities of the relevant structures.
THE PRINCIPLE OF ESTOPPEL IN THE ARBITRATION (ARBITRATION)
Authors:   M.A. Magomedova Dagestan State University, Magomedova M.A. , Khizriev Sh.A. ,   Sh.A. Khizriev Dagestan State University
Published: January 2021

The article is devoted to the institution of estoppel, which is new for Russian law. Based on the analysis of the opinions of scientists regarding the legal nature of estoppel and its definitions, the author comes to the conclusion that the estoppelеin arbitration (arbitration) is a principle of law that guarantees the fair procedural behavior of the parties to the arbitration. The article analyzes the norms of the federal law on arbitration, which contain the rules of estoppel, which made it possible to define estoppel in arbitration proceedings and classify it into types.
ELECTRONIC EVIDENCE IN THE INVESTIGATION OF CRIMES: THE EXPERIENCE OF THE RUSSIAN FEDERATION AND FOREIGN COUNTRIES
Authors:   E.V. Christinina Omsk state agrarian University named after P.A. Stolypin, Christinina E.V.
Published: January 2021

The scientific article is devoted to important issues related to the peculiarities of legal regulation of electronic media used as evidence in the investigation of a criminal case. The object of research of the scientific article is the law enforcement activity of the preliminary investigation bodies on the use of electronic evidence in the investigation of crimes. The article pays special attention to the purpose and production of individual investigative actions, during which electronic evidence is collected and evaluated. The subject of research in the scientific article is a set of norms established by the criminal procedure code of the Russian Federation and the opinions of procedural scientists regarding the use of electronic evidence in the investigation of crimes. The article analyzes the experience of foreign countries in the use of electronic evidence in the investigation process. The conclusion about the necessity and importance of using electronic evidence in a criminal case is summarized.
TRIPARTITUM (THREE BOOKS) AS THE MEDIEVAL HUNGARIAN USUALLY-LEGAL SOURCE OF LAW
Authors:   O.A. Plotskaya Syktyvkar State University named after Pitirim Sorokin, Plotskaya O.A.
Published: January 2021

In this work, the medieval Hungarian source of law, the Tripartitum of IstvanVerbötsi, has been investigated. Considerable attention is paid to the historical and legal analysis of the articles of the text of the monument of law. The work identifies and examines various Hungarian legal customs prevalent at the beginning of the 16th century.
MENINGKATKAN KARAKTER DAN HASIL BELAJAR IPS MENGGUNAKAN METODE BERMAIN PERAN PADA SISWA SD
Authors: Wahyudi Achmad Basari Eko , Suardiman Siti Partini
Published: January 2021

Penelitian ini bertujuan untuk meningkatkan karakter dan hasil belajar IPS menggunakan metode bermain peran pada siswa kelas IV SDN Tridadi Sleman. Peningkatan karakter difokuskan pada tiga aspek yaitu kejujuran, kerja sama, dan tanggung jawab. Penelitian ini merupakan penelitian tindakan kelas yang dilaksanakan dalam tiga siklus. Pengumpulan data dilakukan melalui observasi, catatan lapangan dan tes hasil belajar. Hasil penelitian menunjukkan bahwa proses pembelajaran IPS dengan penerapan metode bermain peran dapat meningkatkan karakter siswa. Peningkatan kejujuran, kerja sama dan tanggung jawab dari Siklus I, II, dan III dimana kejujuran pada Siklus I, II, dan III berturut-turut 42,85%, 52,9%, dan 67%. kerja sama Siklus I, II, dan III memperoleh 42,14%, 51,9%, dan 62%. Sedangkan tanggung jawab pada Siklus I, II, dan III secara berurutan 44,6%, 54,1%, dan 64,1%. Peningkatan hasil belajar pada Siklus I, II, dan III berturut-turut 66,5, 72,92 dan 74,85. Jadi penerapan metode bermain peran dapat meningkatkan karakter dan hasil belajar siswa kelas IV SDN Tridadi Sleman. Kata kunci: karakter, hasil belajar kognitif, bermain peran, kejujuran, kerja sama dan tanggung jawab.
PENGEMBANGAN MULTIMEDIA PEMBELAJARAN MATEMATIKA PADA MATERI BILANGAN BULAT KELAS IV SDN LEMPUYANGAN I YOGYAKARTA
Authors: Fredy Fredy , Soenarto Sunaryo
Published: January 2021

Penelitian ini bertujuan: (1) mendeskripsikan prosedur pengembangan multimedia pembelajaran matematika pada materi Bilangan Bulat kelas IV SD yang layak digunakan untuk meningkatkan hasil belajar kognitif siswa, (2) mendeskripsikan kelayakan produk multimedia pembelajaran matematika di SD kelas IV pada materi Bilangan Bulat ditinjau dari aspek materi dan aspek media, dan (3) mengetahui keefektifan multimedia pembelajaran matematika kelas IV SD pada materi Bilangan Bulat ditinjau dari hasil belajar siswa. Data yang dikumpulkan berasal dari ahli materi, ahli media, dan siswa. Instrumen pengumpulan data berupa instrumen penilaian produk oleh ahli materi, ahli media, dan siswa serta instrumen tes berupa soal pilihan ganda. Analisis data yang digunakan adalah statistik deskriptif. Hasil penelitian ini adalah sebagai berikut: (1) pengembangan multimedia ini dilaksanakan sesuai prosedur pengembangan multimedia yaitu perencanaan, desain, dan pengembangan (2) kelayakan produk pada aspek materi/isi diperoleh skor sebesar 55 (kategori baik sekali), aspek pembelajaran sebesar 57 (kategori baik sekali), aspek pemrograman sebesar 51 (kategori baik), dan aspek tampilan sebesar 52 (kategori baik). Hasil uji t menunjukkan bahwa skor thitung lebih besar dari ttabel (4,034 > 2,01), dan hasil uji n-gain menunjukkan bahwa peningkatan hasil belajar siswa kelas eksperimen lebih tinggi dibandingkan dengan kelas kontrol (0,57 > 0,42), sehingga dapat disimpulkan bahwa pembelajaran dengan menggunakan multimedia lebih efektif dibandingkan dengan pembelajaran menggunakan media powerpoint dalam meningkatkan hasil belajar siswa. Kata kunci: multimedia, matematika, bilangan bulat, keefektifan pembelajaran
EVALUASI KEMAMPUAN GURU DALAM MENGIMPLEMENTASI PEMBELAJARAN TEMATIK DI SD KECAMATAN SALAHUTU KABUPATEN MALUKU TENGAH
Authors: Nurmin Nurmin , Kartowagiran Badrun
Published: January 2021

Evaluasi ini bertujuan untuk mengungkapkan kemampuan guru dalam mengimplementasi pembelajaran tematik di sekolah dasar (SD) di Kecamatan Salahutu, Kabupaten Maluku Tengah yang terkait dengan kemampuan guru dalam perencanaan pembelajaran tematik, pelaksanaan pembelajaran tematik, dan penilaian pembelajaran tematik. Evaluasi yang dilakukan terhadap kemampuan guru dalam mengimplementasi pembelajaran tematik menggunakan metode deskriptif dan pendekatan kuantitatif serta menggunakan model evaluasi Stake’s Countenance Model. Hasil evaluasi menunjukan: (1) Sebagian besar (91,2%) guru SD di Kecamatan Salahutu, Kabupaten Maluku Tengah menyatakan perencanaan pembelajaran tematik dengan kategori cukup baik. (2) Sebagian besar (76,5%) guru SD di Kecamatan Salahutu, Kabupaten Maluku Tengah melaksanakan proses pembelajaran tematik dengan kategori cukup baik. (3) Sebagian besar (91,2%) guru SD di Kecamatan Salahutu, Kabupaten Maluku Tengah mampu melaksanakan penilaian pembelajaran tematik dengan kategori cukup baik. Kata kunci: evaluasi program, pembelajaran tematik.
PENGEMBANGAN BUKU TEKS TEMATIK TEMA PERMAINAN UNTUK KELAS III SDN TRIDADI SLEMAN YOGYAKARTA
Authors: Barus Yohannes Kurniawan , Djukri Djukri
Published: January 2021

Penelitian ini bertujuan untuk menghasilkan buku teks tematik “tema Permainan”. Penelitian ini merupakan Research and Development (R&D). Pengembangan dilakukan dengan mengacu pada model pengembangan 4-D yang meliputi tahap Define, Design, Develop, dan Dissemination. Subjek pada penelitian ini adalah siswa kelas III SD Negeri Tridadi yang berjumlah 28 orang. Hasil penelitian menunjukkan sebagai berikut: (1) Penilaian dari ahli materi dan media terhadap buku teks tematik tema permainan ditinjau dari aspek kelayakan isi berkategori “sangat baik”, aspek penyajian berkategori “Sangat Baik”, aspek kebahasaan berkategori “Sangat Baik”, dan aspek kegrafikan berkategori “Sangat Baik”. Penilaian dari guru aspek kelayakan isi berkategori “Baik”, aspek penyajian “Sangat Baik”, aspek kebahasaan berkategori “Baik”, dan aspek kegrafikan berkategori “Baik”. (2) Respon siswa terhadap buku teks yang dikembangkan menunjukkan respons yang “Baik”, (3) Efektivitas buku teks tematik yang dikembangkan termasuk dalam kategori “Tinggi”, ditunjukkan dari rerata skor gain seluruh siswa kelas III dalam uji coba terbatas dan diperluas sebesar 0,71. Kata kunci: pengembangan, buku teks tematik, tema permainan
PERBANDINGAN KOMPETENSI SOSIAL SISWA KOMUNITAS HOMESCHOOLING DENGAN SISWA REGULER SD MUHAMMADIYAH 1 SURAKARTA
Authors: Wijayarto Budi , Haryanto Haryanto
Published: January 2021

Penelitian ini bertujuan untuk mengetahui perbedaan kompetensi sosial anak yang mengikuti model pendidikan homeschooling dan model pendidikan konvensional. Subjek dalam penelitian ini adalah siswa berusia 9-13 tahun, laki-laki dan perempuan. Teknik pengambilan data menggunakan metode angket. Adapun angket yang digunakan adalah skala kompetensi sosial yang disusun oleh peneliti sendiri dengan mengacu pada aspek-aspek yang dikemukakan oleh Frey & Bos (2012) hingga dihasilkan aitem sebanyak 24 aitem. Metode analisis data yang dilakukan dalam penelitian ini adalah dengan menggunakan fasilitas program SPSS 16.0 for Windows, untuk menguji apakah terdapat perbe-daan kompetensi sosial anak yang mengikuti model pendidikan homeschooling dan konvensional. Metode analisis data yang dilakukan dalam penelitian ini adalah dengan menggunakan fasilitas program SPSS 16.0 for Windows dengan Teknik Independent Samples T-tes. Hasil penelitian menunjukkan bahwa terdapat perbedaan kompetensi Sosial antara siswa homeschooling dengan siswa SD reguler, dimana siswa homeschooling lebih tinggi kompetensi sosialnya daripada siswa sekolah reguler. _________________________________________________________________________________________________________________________________________________ COMPARISON SOCIAL COMPETENCE BETWEEN HOMESCHOOLERS IN SOLO WITH REGULAR ELEMENTARY STUDENTS IN SD MUHAMMADIYAH 1, SOLO ABSTRACT The purpose of this research is to know the difference social competence between children that following homeshooling education model and regular education model.  The subjects in this research were childrens with 9-13 of age, boys and/or girls. The data was collected using social competence scale that was made by writer also the items from aspects that was publicated by Frey and Bos (2012). The data was tested by using SPSS 16.0 for Windows, to know are there any differences of social competence between children that following homeschooling education model and regular. The data was tested by using SPSS 16.0 for Windows by The Independent Technic Samples T-test. Based on the test, there were any differences of social competence between children that following homeschooling education model and regular education model, in which the social competence of children that following homeschooling education model is higher than children that following regular education model. Keywords: social competence, homeschooling
PENGEMBANGAN BUKU PELAJARAN TEMATIK-INTEGRATIF BERBASIS NILAI KARAKTER DISIPLIN DAN TANGGUNG JAWAB DI SEKOLAH DASAR
Authors: Sari Indah Perdana , Syamsi Kastam
Published: January 2021

Penelitian ini bertujuan untuk menghasilkan dan mengetahui keefektifan buku pelajaran tematik-integratif dengan tema “Mari Bermain Sambil Berolahraga” berbasis nilai karakter disiplin dan tanggung jawab untuk peserta didik kelas III SD. Penelitian ini merupakan penelitian dan pengembangan (R&D) dengan model Brog & Gall. Uji coba produk melibatkan 67 peserta didik kelas III SD 2 Padokan Bantul. Hasil penelitian menunjukkan buku pelajaran yang dikembangkan dari aspek kelayakan isi berkategori “sangat baik”, aspek kebahasaan berkategori “sangat baik”, aspek penyajian berkategori “sangat baik”, dan aspek kegrafikaan berkategori “sangat baik”. Hasil untuk nilai karakter disiplin menunjukkan uji-t= -3,110 dengan P sebesar 0,000 dan nilai karakter tanggung jawab menunjukkan hasil uji-t= -4,440 dengan P sebesar 0,003. Selain itu, nilai hasil belajar menunjukkan 100% peserta didik tuntas dalam pembelajaran. ________________________________________________________________________________________________________________________________________________________ DEVELOPMENT THEMATIC-INTEGRATIF TEXTBOOKS BASED ON DISCIPLINE AND RESPONSIBILITY VALUES IN ELEMENTARY SCHOOLABSTRACT This study aims to: produce and determine the effectiveness of thematic-integrative textbooks with the theme of "Let's Play while Exercising" based on discipline and responsibility values. This study is a Research and Development (R & D) with a Brog and Gall model. The tryout involved 67 students of grade III in Padokan Bantul Elementary School 2. This is evidenced by the results of expert evaluation showing the textbooks  developed is terms of the feasibility contents category is "very good", aspects of language category is "very good", aspects of presentation category is "very good", and aspect of grapichlly category is "very good". As for discipline value results of t-test = -3.110 with P values of 0.000 and the value of responsibilities results of t-test = -4.440 with P values 0.003. Moreover, the data of the learning result show is 100% learning mastery. Keywords: textbooks, thematic-integrated, discipline value, responsibiliy value