bluuebunny/crossref_metadata_2025 huggingface dataset:
Habitar el traje. Una reflexión sobre el vestuario teatral
Authors: Gutman Laura
Published: November 2019

Mediante una reflexión sobre la función icónica y dramática del traje teatral se pretende acercar al lector a una lectura sobre su particular disponibilidad poética dentro del entramado simbólico del lenguaje teatral. Lo que el traje por sí mismo cuenta, no pertenece solo a la historia del teatro, sino apunta a una mayor comprensión de los fenómenos sociales y habla de una posición respecto a la necesidad humana de producir fenómenos culturales. El traje teatral resulta así atravesado por los elementos constitutivos de la cultura, la historia yel lenguaje.
El 3D una vez más. ¿Esta vez sí ? El cine en relieve ante los espectadores contemporáneos
Authors: Russo Eduardo
Published: November 2019

A partir del actual auge de tecnologías y producciones audiovisuales en 3-D en el cine, la televisión digital y los new media, el artículo examina, desde una perspectiva genealógica atenta a la hibridación entre tecnologías, medios y prácticas, la prolongada historia de la percepción en relieve. Atendiendo a sus desarrollos tempranos, muy anteriores a los medios audiovisuales, y a intentos previos de instalación en el espectáculo audiovisual de alcance masivo, así como a algunos esbozos de reflexión teórica sobre el cine 3-D, el trabajo concluye con el análisis de algunas perspectivas y paradojas actuales, ante la renovación de las aspiraciones tridimensionales en el audiovisual contemporáneo.
Arte, moda y consumo cultural
Authors: Joly Verónica
Published: November 2019

En los últimos años se ha acentuado el valor artístico y cultural de las producciones de moda. Las tiendas del diseño de autor, el museo, el centro cultural e incluso la pasarela y el shopping disponen múltiples espacios para el diálogo entre el mercado, la moda y el arte. Lenguajes como los de la instalación, la performance y la intervención suelen ser los más usuales al momento de situar al indumento en el espacio artístico. Simultáneamente, estos recursos son apropiados por los creadores en la pasarela y en las vidrieras de los emprendimientos comerciales del diseño de autor. Este artículo se propone analizar las diversas lógicas de significación que en las sociedades actuales potencian el modo en que el vestido se presenta, es apreciado y reconocido visualmente por el espectador como parte de la cultura legítima.
Subjetividades Inestables
Authors: Romero Moscoso Alberto Carlos
Published: November 2019

Una pregunta por la subjetividad tiene como horizonte propositivo una reflexión sobre la condición humana. Si bien en el mundo moderno el cuerpo se consolidó como paradigma del proyecto de entendimiento de la naturaleza, por el camino de la ciencia, el proyecto tecnológico e industrial ha puesto en evidencia la condición tecno política del mundo en el que habitamos y por esta vía ha permitido una colonización de las ciencias de la vida, que han instaurado una condición de lo humano como equivalente de una condición de lo viviente. El texto intenta sugerir una reflexión en torno al carácter ético del problema de la subjetividad enel mundo contemporáneo, a partir de la relación estrecha que hoy vincula la idea de sujeto conevaluaciones de la relación del ser humano con los desarrollos técnico científicos, vía por la que no solo se amplía la idea de sujeto, sino que intenta estructurarse de manera indisociable de una pregunta que cada día cobra mayor fuerza y que tiene que ver con el asunto de lo vivo.
Idear la forma. Capacitación creativa
Authors: Cruz García Cayetano José
Published: November 2019

Más allá de todo lo que nos une, la creatividad es una faceta de nuestro pensamiento que nos puede definir como sujetos creativos, y que se pone de manifiesto en disciplinas concretas del quehacer humano. Para el diseñador es una herramienta clave para obtener nuevas soluciones; y en la acción proyectual, lo es la capacidad de idear, imaginar, intuir soluciones,... hasta el punto en el que podemos identificar a una persona como agente creativo. Desde el dibujo, en este artículo, se presentan algunas metodologías desarrolladas para entrenar y dotar de habilidades al sujeto; tales, que le permitan hacer presente la creatividad en la acción proyectual del diseño.
Del universo simbólico al arte como terapia. Un camino de descubrimientos
Authors: Galvis Pedrosa Paola
Published: November 2019

El siguiente texto presenta un recorrido teórico práctico que inspira el quehacer arte terapéutico y sus beneficios, en la forma de vida de comunidades indígenas y afrocolombianas de la región chocoana del Bajo Atrato Colombiano. El universo simbólico, punto de convergencia entre uno y otro, abre ante estos lugares, posibilidades de creación, de recuperación de la salud, de resistencia, posibilidades de ser, de hacer, de crear y de creer. La exploración empieza ubicando al lector en tal región colmada de selva y río, poblada porcomunidades con formas de vivir, con tradiciones ancestrales y con cosmovisiones que les han permitido resistir poderosas arremetidas bélicas producto de intereses territoriales, económicos y militares. Lo anterior como preámbulo y pregunta sobre cómo trascender este valiosísimo recurso al ámbito terapéutico individual o grupal, y al reconocimiento de las subjetividades que ante en estos se despliegan, en contextos enmarcados por las características del pensamiento moderno occidental. Continua un tejido entre uno y otro contexto y entre el uso de la Arteterapia como dispositivo que, similar a los mitos fundacionales de las comunidades chocoanas, delata lo más profundo del bagaje humano en el intento de construir una sensación de identidad, de pertenencia, de sentir y expresar la riqueza del afecto más allá de las exigencias de racionalismo actuales. Al crear, establecemos un dialogo entre el yo y la vida y podemos decidir abandonar, dejar y perder aquello que nos aleja del deseo de sentir, aprender, conocer o explorar. Aquí reside el poder de la creatividad y la importancia de los diferentes métodos que estimulen su desarrollo.
Los aportes de la creatividad ante la dificultad reflexiva del estudiante universitario
Authors: Vigovsky Eduardo
Published: November 2019

Los estudiantes universitarios encuentran cada vez mayores dificultades en analizar, comprender, relacionar y sintetizar. Los alumnos toman por cierto todo lo que figura en internet y lo dan por válido sin un espíritucrítico, se ubican en una posición de cómodos espectadores. Los profesores universitarios debiéramos cambiar nuestra manera de impartir docencia, dejando de ser ese gran Otro que nos confiere el alumno. La creatividad de los alumnos universitarios representa un reto profesional y una posibilidad de crecimiento personal de enorme valor humano.
Desarrollo Humano: un lugar epistémico
Authors: Humberto Arias Julián
Published: November 2019

Amparado en las múltiples perspectivas de análisis, así como de crítica sobre el desarrollo, el texto hace un llamado a considerar el desarrollo humano desde la imagen alegórica de ver1; cierta forma de perspectiva socio-histórica. Al final expresiones mediante correlatos y otras formas de diálogos con conceptos conexos, que expresan lo contingente de estatutos epistemológicos de las ciencias humanas sin lograr excluir otras formas de saber, ni los rasgos disciplinarios de las ciencias sociales y humanas. El texto propone una reflexión sobre el ver, juega un papel fundamental la preocupación sobre el lenguaje como vía y medio de problematización; en particular sobre comprensiones y perspectivas del desarrollo humano; que parodiando aquella pregunta que hicieran Adorno y Horkheimer, sobre lo que la luz oculta, bien sirve para referir la reflexión sobre la jurídicas del desarrollo humano; sin detenerse en lo polémico del significado del concepto desarrollo, mejor aun vista desde sus formas de transcursividad conceptual, haciendo posible la consideración sobre la noción del lugar epistémico.
Subjetividad en la didáctica de las carreras proyectuales. Grupos de aprendizaje; evaluación
Authors: Basterrechea Lucía
Published: November 2019

Un campo de reflexión en la didáctica de las carreras proyectuales está orientado hacia las características de los grupos de aprendizaje y la evaluación de los estudiantes. De qué manera se desarrollan las relaciones entre los integrantes del grupo clase; cómo se configura la terna docente-estudiante-conocimiento que constituye todo acto pedagógico; cuáles son los parámetros a seguir en la evaluación para evitar las injusticias; cómo estimar verdaderamente el conocimiento del tema a través de una muestra gráfica o tridimensional realizada en circunstancias poco favorables para el alumno desde lo emocional. A través de miradas diferentes, desde la didáctica y con un enfoque desde la complejidad, se intentará un acercamiento a la dinámica de trabajo en el taller dentro de una carrera de diseño. Los casos mencionados pertenecen a mi ejercicio profesional en la docencia, en la carrera de Arquitectura y en la de Diseño de Indumentaria y Textil.
El Diseño de experiencias significativas en entornos de aprendizaje
Authors: Dussán Aguirre Rosmery
Published: November 2019

El incremento de la competitividad en las organizaciones a nivel general, incluyendo las Instituciones de Educación Superior y en complementación la diversificación de las necesidades de los usuarios de ser cada vez más eficientes en sus procedimientos profesionales, hace necesario usar herramientas de creación, comunicación, entrega de valor agregado y una adecuada administración de las relaciones entre las partes. Es posible fortalecer esta relación por medio de estrategias que desde el diseño se puedan implementar como metodologías de aprendizaje, donde no sólo los estudiantes logren entender los contenidos programáticos, sino que a su vez, se puedan sumergir en dinámicas que luego serán primordiales en su quehacer profesional y darán los elementos de particularidad y rasgos de aporte subjetivo desde su creatividad. Es por esto, que el diseño de experiencias significativas responde a nuevas tendenciasde los mercados y a la evolución del consumidor y de la cultura de la innovación. Por lo tanto, el objetivo de esta reflexión se centra en reconocer a través de un proyecto para formar, capacitar y fortalecer las dinámicas de las clases ofreciendo entornos con diseño de experiencias como herramientas de aprendizaje.
Habitancia y Comunidades de Sentido. Complejidad Humana y Educación. Consideraciones acerca del acto educativo en Diseño
Authors: Polo Flórez Viviana
Published: November 2019

¿Que se enseña, y que se aprende? La educación con sus diversas vertientes como la reflexión sistemática, compendio de métodos formativos para un contexto particular, en si misma se ha convertido en una corriente de posibilidades pragmáticas, eficientes y concluyentes, que han enmarcado al sujeto en un contenedor de conocimientos, como entes operantes desde las reacciones guiadas por un impulso o caso de estudio, y no en un sistema que propenda complementariedad, unidad y beneficio general, desde la perspectiva sensible y vital. En este gran espectro de posibilidades, la validez del enseñar y el aprender esta en reconocer como premisa fundamental a un sujeto, a un hombre o mujer de una sociedad, que se hayaconfrontado desde el aula a poseer más que conocimientos y el eje central de su quehacer, de su rol, y se haya estructurado desde la esencia en la educación y de la condición humana. Este escrito, plantea desde la óptica del diseño una reflexión en torno a los elementos de estructura y poder, que se dan desde las aulas de diseño y desde los roles de quienes las ocupan (DocenteEstudiante), en donde la emergencia creativa, busca no solo la diferenciación de los resultados tangibles -producto de un proceso de diseño- , sino el reconocimiento de los sujetos que por medio del acto educativo ayudan a ser a los otros.
Moda, estilo y ciclo de vida de los productos de la industria textil
Authors: Bur Aníbal
Published: November 2019

La moda refleja el gusto de una época, los valores y las opiniones dominantes. Cuando las personas piensan en la moda, generalmente, imaginan un mundo de fantasía conformado por diseñadores, modelos y prendas atractivas. En realidad, la moda no se refiere solamente a la indumentaria, sino que se aplica a cualquier producto o servicio de consumo masivo como, por ejemplo, automóviles, música, mobiliario, revistas, destinos turísticos, etc. Si consideramos la moda desde el punto de vista de la indumentaria, encontramos que tiene una dimensión sociocultural y, además, una dimensión económica. En relación a esta última, podemos señalar que el marketing de la moda tiene como funciones determinar qué productosse van a vender, a quiénes, a qué precios, cómo se van a comunicar y cuáles serán sus canales de distribución. Frecuentemente, los términos moda y estilo se confunden. La moda se refiere a todo productoque se convierte en popular durante un período de tiempo y en un determinado lugar. En cuanto al estilo, éste se refiere a las características y los detalles que diferencian unos productos de otros. Dentro de un mismo estilo puede haber muchas variaciones en su creación: estamos en presencia de los diseños. Siempre hay muchos más diseños que estilos. Cuando un estilo se convierte en popular se transforma en moda.A los productos de moda del rubro indumentaria, al igual que cualquier producto, se les puede aplicar el modelo de ciclo de vida. Este modelo supone que los productos que se introducen a los mercados competitivos atraviesan un ciclo predecible en el tiempo. Cada etapa recibe un nombre específico: introducción, crecimiento, madurez y declinación. Conocer la etapa del ciclo en la que se encuentra el producto de moda permite a los especialistas de marketing, diseñar la estrategia más eficaz para comercializarlo, aspecto especialmente relevante en los mercados altamente competitivos en los que la industria textil debe actuar.
La reputación como ventaja competitiva sostenible
Authors: González Susana G.
Published: November 2019

En los actuales contextos globalizados, las empresas se encuentran en una búsqueda incesante por diferenciarse. La oferta de bienes y servicios en general ha crecido, tanto en cantidad como en calidad. A tal grado se produce este fenómeno que, si la empresa no encuentra una buena razón (y la comunica correctamente) para ser elegida por los consumidores, se condena a perder mercado y/o rentabilidad. Las tradicionales fuentes de ventaja competitiva se encuentran sobreexplotadas. Además de presentar problemas con su sostenibilidad. En principio, es necesario definir la reputación corporativa y diferenciarla de otros conceptos con los cuales se relaciona. Con esta base, se procederá a referirse a la reputación corporativa y la generación de valor. Luego, determinar las principales características de la reputación y examinar hasta qué punto pueden constituirse en una ventaja competitiva. Y, por último, indagar si es posible la sostenibilidad. Si así fuera, las erogaciones realizadas para generar reputación favorable podrían considerarse inversiones y calcularse el retorno de las mismas. Se abre así, un campo de actuación de los licenciados en Relaciones Públicas que seguramente encontrarán argumentos sólidos para interesar a la gente de negocios en esta temática. Este trabajo pretende ser un aporte en este sentido.
La naturaleza estratégica del proceso de branding
Authors: Llamas Elda
Published: November 2019

El branding, anglicismo con el que se denomina a la creación y gestión estratégica de una marca, cobró notoriedad en la década del ’90 incorporándose al debate académico y a la actividad profesional del campo disciplinar del diseño y el marketing. En ese trayecto provocó cierta confusión respecto a la naturaleza –a veces estratégica y a veces táctica– de la actividad. Este hecho da lugar a la reflexión teórica sobre el nuevo territorio y a explorar la actividad que rodea a la construcción de una marca, en un intento por descubrir perspectivas teóricas que ayuden a comprender el proceso. Al hacerlo, se examina la noción demarca como sistema bipolar de producción y proyección de imágenes, y se exploran las fases del proceso de desarrollo de la marca en paralelo al proceso de planeamiento estratégico. Finalmente, se analiza la influencia que recibe el proceso de diferentes escuelas de pensamiento estratégico para descubrir las nuevas fronteras que atraviesa este paradigma.
Serbia multiculural diseñada para el mundo”. Claves para la imagen que representará a la nación Serbia
Authors: Pantovic Branislav
Published: November 2019

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Diseñar a partir de la identidad. Entre el molde y el espejo
Authors: Veneziani Marcia
Published: November 2019

El presente artículo muestra a través de un caso –el de la diseñadora argentina Deby Szmuch– un modo de entender la moda desde la “alta costura individualizada”. La identidad personal constituye el eje a partir del que se realiza indumentaria. Un modo bien argentino donde se mezclan las historias de los inmigrantes, las propias historias y la inspiración artística en un entramado complejo entre la biografía y el diseño.
Arte textil y tradición en la Provincia de Catamarca, noroeste argentino
Authors: González Eliçabe Ximena
Published: November 2019

Las tradiciones textiles en la Provincia de Catamarca, constituyen parte de una identidad cultural conformada a partir de elementos muy pujantes provenientes de distinto origen. Estos se traslucen tanto en estilos y técnicas de piezas de exquisita estética y calidad. Evidencian además, la historia de las industrias y manufacturas textiles que aportaron al desarrollo de esta actividad, considerada por sus habitantes como parte de suidiosincracia que -lamentablemente- con los años tiende a desaparecer.
Analysis on the Aeroelastic Stability of Open Cylindrical Shells in Subsonic Airflow Using the Theoretical and Two-way CFD/CSD Coupled Methods
Authors: Chai Yu-Yang , Li Feng-Ming , Song Zhi-Guang
Published: November 2019

The aeroelastic stability of an open cylindrical shell in subsonic airflow is analyzed. The equation of motion of the
open cylindrical shell whose one surface is subjected to the subsonic airflow is established based on the Donnell
shell theory and transformed into ordinary differential equations using Galerkin’s method. The linear potential
flow theory is applied to derive the aerodynamic pressure. The natural frequencies of the aeroelastic system are
obtained, from which the flow velocity for the open cylindrical shell under instability can be calculated. The
effects of the material and geometric parameters on the critical instability velocity are discussed. Furthermore, the
open cylindrical shell is modelled using the finite element software ANSYS. The time domain responses of the
structure in subsonic airflow are calculated using the two-way CFD/CSD (computational fluid-structure dynamics)
coupled method. From the results, it can be seen that with the increase of the thickness and elastic modulus of the
shell, the critical instability velocity increases also. The open cylindrical shell with a smaller radius shows better
aeroelastic properties than that with a larger radius. The time domain responses obtained by the CFD/CSD method
are compared with those calculated by the theoretical method, and the results of these two methods have a good
agreement with each othe
Characteristics of In-Plane Waves in Composite Plates
Authors: Renji K. , Kelvina Florence S. Josephine , Deshpande Sameer
Published: November 2019

The high frequency dynamic excitations generate both in-plane as well as bending waves in structures. In aerospace applications, many of these structures are made of composite materials. There are two types of in-plane motions, longitudinal and in-plane shear. Although these motions are uncoupled in isotropic materials, composite structures show coupled behaviour. The works reported on in-plane waves in composite structures assume that two in-plane motions are uncoupled as in isotropic plates. In this work, characteristics of the in-plane waves in composite laminated plates are investigated. Expressions for wavenumber, phase speed and group speed are derived. It is seen that in composite plates the two in-plane waves are coupled in longitudinal and shear propagations and are non-dispersive. The phase speeds of in-plane waves in composite plates can be much different from those determined using the expressions for isotropic plates where the waves are uncoupled. To validate the expressions derived the phase speeds of in-plane waves in a typical composite panel are determined experimentally. It is seen that the experimentally obtained phase speeds match well with the theoretical results.
Vibration Modelling and Verification for Rotor-Support-Casing Coupling System with Misalignment Fault
Authors: Wang Nanfei , Jiang Dongxiang , Yang Yizhou
Published: November 2019

Misalignment is one of the common malfunctions that occur in rotating machines. Effects of misalignment on the
casing vibration response of a rotor-support-casing (RSC) coupling system is investigated in detail. The model of
an RSC coupling system is established using the lumped mass method. The coupling effects between the rotor,
support and casing are fully considered. A misalignment model is proposed, and equivalent misalignment force is
applied on corresponding lumped mass points. Nonlinear factors of bearing, such as the clearance of bearing, oil
film force, nonlinear Hertzian contact force, and the varying compliance vibration are developed. The influences
of oil film thickness and bearing size are considered in the nonlinear oil film force model. By using a numerical
method, the governing equations of the system are solved to obtain the steady-state vibration. The simulation
results from a coupling model are compared with the experimental results and the effectiveness of the new model
is verified. It has been found that spectrums and orbit plots are effectively used to reveal the unique nature of
misalignment faults, leading to reliable misalignment diagnostic information.
Two-Temperature Thermoelastic Damping of a Gold Nano-Beam Resonator with Variable Young's Modulus
Authors: Youssef Hamdy M. , El-Bary Alaa A.
Published: November 2019

This paper deals with the thermoelastic damping (Q-factor) of a gold nano-beam resonator and is based on twotemperature thermoelasticity models. An explicit formula of the Q-factor has been derived when Young’s modulus
is variable as a function of the room temperature. The length of the beam and Young’s modulus has been studied
with comparison being made between the Biot model and the Lord-Shulman model (L-S). The numerical results
show that the values of beam length, the relaxation time parameter, and the two-temperature parameter have a
strong influence on the thermoelastic damping quality factor.
Relationship of Causality Between Spot And Futures Markets of Borsa Istanbul Index 30 and Dow Jones Industrial Average
Authors: Özdemir Letife , Özen Ercan , Grima Simon
Published: November 2019

Futures markets are mainly used as a tool for price discovery and for risk management on the spot markets and enable diversification for international portfolio investments. With this study we aim (1) to investigate the causality relationship between futures markets and spot market and (2) to examine the causality relationship between futures markets and spot markets in different countries. We are interested in both the futures markets - spot market relations and the interactions between the markets at international level. For variables we used the the BIST30 spot index and BIST30 futures contract representing the Borsa Istanbul market and the Dow-Jones 30 index and Dow-Jones 30 futures contract, which are the most important indices representing the US markets. Daily closing price data for the period between 2nd January, 2009 and 18th June, 2018 were analyzed using correlation, unit root test, causality test and regression equations. The results of the study show that the futures markets continue their price discovery role for both the spot markets and futures markets and are influential on other futures and spot markets at international level. These findings are important for investors wanting to invest in Turkey and in similarly considered emerging market economies. It will help investors take informed decisions by providing them with a more efficient price estimations utilizing the futures markets.
Species Delimitation in Sea Anemones (Anthozoa: Actiniaria): From Traditional Taxonomy to Integrative Approaches
Authors: Spano Carlos A. , Canales-Aguirre Cristian B. , Musleh Selim S. , Häussermann Vreni , Gomez-Uchida Daniel
Published: November 2019

The present review provides an in-depth look into the complex topic of delimiting species in sea anemones. For most part of history this has been based on a small number of variable anatomic traits, many of which are used indistinctly across multiple taxonomic ranks. Early attempts to classify this group succeeded to comprise much of the diversity known to date, yet numerous taxa were mostly characterized by the lack of features rather than synapomorphies. Of the total number of species names within Actiniaria, about 77% are currently considered valid and more than half of them have several synonyms. Besides the nominal problem caused by large intraspecific variations and ambiguously described characters, genetic studies show that morphological convergences are also widespread among molecular phylogenies. On the contrary, spatial distribution has been emerging as a more reliable parameter to explain cryptic relationships among sea anemones. Integrative approaches and genome-wide data have been especially helpful to unveil the mechanisms behind the speciation process, which is typically marked by large genetic differences among populations, even from neighbouring localities. This paper further discusses current gaps in our knowledge and offers some future directions on how to address the issue of species delimitation in the extremely polymorphic group of sea anemones.
The Validity and Reliability of the Patient Health Questionnaire-9 in Screening for Post-stroke Depression
Authors: Dajpratham Piyapat , Pukrittayakamee Panate , Atsariyasing Wanlop , Wannarit Kamonporn , Boonhong Jariya , Pongpirul Krit
Published: November 2019

Depression affects about 30% of stroke survivors within five years. Timely diagnosis and management of post-stroke depression (PSD) facilitate motor recovery and improve independence. The original version of the Patient Health Questionnaire-9 (PHQ-9) is one of the good screening tools for post-stroke depression. As yet, no validation studies of depression in Thai stroke patients by the Thai PHQ-9. Methods: The objectives of the study were to determine the criterion validity and reliability of the Thai PHQ-9 in screening for post-stroke depression by comparing with a psychiatric interview as the gold standard. First-ever stroke patients aged ≥ 45 years with a stroke duration 2 weeks–2 years were administered the Thai PHQ-9. The gold standard was a psychiatric interview leading to a DSM-5 diagnosis of depressive disorder. The summed-scored based diagnosis of depressive disorder with the PHQ-9 was obtained. The validity and reliability analyses, and a receiver operating characteristic curve analysis, were performed. Results: 115 stroke patients (mean age, 64 + 10 years) were enrolled. The mean PHQ-9 score was 5.2 + 4.8. Using DSM-5 criteria, 23 patients (20%) were diagnosed with depressive disorder. The Thai PHQ-9 had satisfactory internal consistency (Cronbach’s alpha, 0.78). The algorithm-based diagnosis of the Thai PHQ-9 had low sensitivity (0.52) but very high specificity (0.94) and positive likelihood ratio (9.6). Used as a summed-scored based diagnosis, an optimal cut-off score of six revealed a sensitivity of 0.87, specificity of 0.75, positive predictive value of 0.46, negative predictive value of 0.95, and positive likelihood ratio of 3.5. The area under the curve was 0.87 (95% CI, 0.78–0.96). Conclusions: The PHQ-9 (Thai language version) has acceptable psychometric properties for screening for post-stroke depression, with a recommended cut-off score of 6 or greater in a Thai population. Keywords: depression, Patient Health Questionnaire-9, reliability, screening, stroke, Thai, validity
Quick selenium accumulation in the selenium-rich rice and its physiological responses in changing selenium environments
Authors: Liang Yuanke , Su Yang , Li Ling , Huang Xing , Panhwar Faiz Hussain , Zheng Tengda , Tang Zhichen , Ei Hla Hla , Farooq Muhammad Umer , Zeng Rui , Zhang Yujie , Ye Xiaoying , Jia Xiaomei , Zheng Lanlan , Zhu Jianqing
Published: November 2019

Background:The element selenium (Se) deficiency is thought to be a global human health problem, which could disperse by daily-supplement from Se-rich food. Increasing the accumulation of Se in rice grain is an approach matched to these nutrient demands. Nonetheless, Se is shown to be essential but also toxic to plants, with a narrow margin between deficiency and toxicity. Notably, the regulatory mechanism balancing the accumulation and tolerance of Se in Se-rich rice plants remains unknown. Results:In this study, we investigated the phenotypical, physiological, and biochemical alterations of Se-rich rice in the exposure to a variety of Se applications. Results showed that the Se-rich rice was able to accumulate more abundance of Se from the root under a low Se environment comparing to the Se-free rice. Besides, excessive Se led to phytotoxic effects on Se-rich rice plants by inducing chlorosis and dwarfness, decreasing the contents of antioxidant, and exacerbating oxidative stresses. Furthermore, both phosphate transporter OsPT2 and sulfate transporters OsSultr1;2 may contribute to the uptake of selenate in rice. Conclusions: Se-rich red rice is more sensitive to exogenous application of Se, while and the most effective application of Se in roots of Se-rich rice was reached in 20μM. Our findings present a direct way to evaluate the toxic effects of Se-rich rice in the Se contaminated field. Conclusively, some long-term field trial strategies are suggested to be included in the evaluation of risks and benefits within various field managements.
A phenomics-based approach for the detection and interpretation of shared genetic influences on 29 biochemical indices in Chinese south men
Authors: hu yanling , tan aihua , yu lei , hou chenyang , kuang haofa , wu qunying , sun Jinghan , zhou Qingniao , zhu yuanyuan , Zhang Chenqi , wei wei , li Lianfeng , li weidong , huang yuanjie , huang hongli , xie xing , lu tingxi , zhang haiying , yang xiaobo , gao yong , li tianyu , Jiang yonghua , mo zengnan
Published: November 2019

Background: Phenomics provides a new technologies and platforms as a systematic phenome-genome approach. However, few studies have reported on the system mining of shared genetics among clinical biochemical indices based on Phenomics methods, especially in China. This study aimed to apply phenomics to systematically explore shared genetics among 29 biochemical indices based on the Fangchenggang Area Male Health and Examination Survey cohort. Result: A total of 1,999 subjects with 29 biochemical indices and 709,211 single nucleotide polymorphisms were subjected to phenomics analysis. Three bioinformatics methods, namely, Pearson test, Jaccard index, and linkage disequilibrium score regression , were used. Results showed that 29 biochemical indices were from a network. IgA, IgG, IgE, IgM, HCY, AFP and B12 were in the central community of 29 biochemical indices. Key genes and loci associated with metabolism traits were further identified, shared-genetics analysis showed that 29 SNPs (P < 10 -4 ) were associated with three or more traits. After integrating the SNPs related to two or more traits with the GWAS catalog, 31 SNPs were found to be associated with several diseases (P < 10 -8 ). Taking ALDH2 as an example to preliminarily explore its biological function, we also confirmed that rs671 (ALDH2) polymorphism affected multiple traits of osteogenesis and adipogenesis differentiation in 3T3-L1 preadipocytes. Conclusion: All these findings indicated a network of shared genetics and 29 biochemical indices, which will helpfully understand the genetics participated in biochemical metabolism.
Transcriptome analysis of the fungal pathogen Rosellinia necatrix during infection of a susceptible avocado rootstock identifies potential mechanisms of pathogenesis
Authors: Zumaquero Adela , Kanematsu Satoko , Nakayashiki Hitoshi , Matas Antonio , Martínez-Ferri Elsa , Barceló-Muñóz Araceli , Alfaro Fernando Pliego , Lopez-Herrera Carlos , Cazorla Francisco , Prieto Clara Pliego
Published: November 2019

Background White root rot disease caused by Rosellinia necatrix is one of the most important threats affecting avocado productivity in tropical and subtropical climates. Control of this disease is complex and nowadays, lies in the use of physical and chemical methods, although none have proven to be fully effective. Detailed understanding of the molecular mechanisms underlying white root rot disease has the potential of aiding future developments in disease resistance and management. In this regard, this study used RNA-Seq technology to compare the transcriptomic profiles of R. necatrix during infection of susceptible avocado `Dusa´ roots with that obtained from the fungus cultured in rich medium. Results The transcriptomes from three biological replicates of R. necatrix colonizing avocado roots (RGA) and R. necatrix growing on potato dextrose agar media (RGPDA) were analyzed using Illumina sequencing. A total of 12,104 transcripts were obtained, among which 1,937 were differentially expressed genes (DEG), 137 exclusively expressed in RGA and 160 in RGPDA. During the root infection process, genes involved in the production of fungal toxins, detoxification and transport of toxic compounds, hormone biosynthesis, gene silencing and plant cell wall degradation were overexpressed. Interestingly, 24 out of the 137 contigs expressed only during R. necatrix growth on avocado roots, were predicted as candidate effector proteins (CEP) with a probability above 60%. The PHI (Pathogen Host Interaction) database revealed that three of the R. necatrix CEP showed homology with previously annotated effectors, already proven experimentally via pathogen-host interaction. Conclusions The analysis of the full-length transcriptome of R. necatrix during the infection process is suggesting that the success of this fungus to infect roots of diverse crops might be attributed to the production of different compounds which, singly or in combination, interfere with defense or signaling mechanisms shared among distinct plant families. The transcriptome analysis of R. necatrix during the infection process provides useful information and facilitates further research to a more in -depth understanding of the biology and virulence of this emergent pathogen. In turn, this will make possible to evolve novel strategies for white root rot management in avocado.
Oral Impact on Daily Performance (OIDP) scale for use in Sri Lankan Adolescents: a cross sectional modification and validation study
Authors: Amilani Uttara , Jayasekara Prasanna , Perera Irosha R , Carter Hannah E , Senanayake Sameera , Kularatna Sanjeewa
Published: November 2019

Background Oral Health Related Quality of Life (OHRQoL) surveys play an important role in understanding subjective patient experiences in oral health care. The Oral Impact on Daily Performance (OIDP) scale is a validated OHRQoL tool that measures the impact and extent to which an individual’s daily activities may be compromised by their oral health. It is commonly used to facilitate oral health service planning. The aim of this study was to modify and validate a Sinhalese version of the OIDP for use in Sri Lankan adolescents. Methods The stage I involved cultural adaptation of the tool through translation and modification. After translation and cultural adaptation, the modified OIDP was tested on 220, 15-19 year secondary school students in the Gampaha district, Sri Lanka. The adolescents completed the modified OIDP scale along with questions on self-reported perceived oral health problems and treatment need which were used to assesses the concurrent validity of the modified OIDP scale. Stage II and III involved the exploring factor structure, validation and a reliability assessment. Factorability was assessed by inspection of correlation matrix and Kaiser-Meyer-Olkin and Bartlett's Test of Sphericity tests as a measure of sampling adequacy. An exploratory factor analysis was carried out using Principal Component Analysis method and factors were rotated using the oblimin method. Results 220 adolescents participated in factor analysis and validation studies. The most prevalent oral health impact related to chewing and enjoying foods, reported by 36.8% of respondents The Kaiser-Meyer-Olkin measure was 0.87 and Bartlett’s test of Sphericity was significant (p<0.001) Cronbach’s alpha was calculated as 0.88, indicating a high level of internal consistency. The principal component analysis produced two factors with Eigen values ranging from 1.12 to 4.40, explaining 70.0% of total variance. Concurrent validity was satisfactory as the OIDP score increased when the adolescents’ perceived oral health decreased.Conclusion This study showed that the modified OIDP scale is applicable for use among adolescents in Sri Lanka. It has promising psychometric properties but further research is required to use this tool in other cohorts.
The Key Candidate Genes in Tubulointerstitial Injury of Chronic Kidney Diseases (CKD) Patients as Determined by Bioinformatic Analysis
Authors: Wang Wanpeng , Shen Jianxiao , Pan Yan , Qi Chaojun , Liang Senlin , Kuai Qiaolin , Zuo Zhi
Published: November 2019

Background: Tubulointerstitial injury (TIL) is common in chronic kidney disease (CKD), which in turn, leads to loss of renal function. The aims of present study were to screen critical genes with tubulointerstitial lesion in CKD by weighted gene correlation network analysis (WGCNA). Methods: GSE104954 gene expression data downloaded from GEO database were used for analysis for differential expression genes(DEGs); Meanwhile, 90 expression data of tubulointerstitial samples in GSE47185 combined with clinic information were applied to WGCNA. According to the enrichment analysis and relationship with estimated glomerular filtration rate (eGFR), the eGFR-associated modules were defined, and the hub gene is selected according to the average intramodular connectivity (Kwithin); Clinical data from Nephroseq were obtained to further validate the relationship between CKD and hub genes. Results: Totally 294 DEGs were screened. Using the WGCNA, we identified 15 co-expressed modules, the blue, brown and yellow modules exhibited strongly association with eGFR, and were significantly enriched in several signaling pathways that have been reported involved in pathogenesis of CKD. Furthermore, it was found that the 4 genes (PLG, ITGB2, CTSS and CCL5) was one of the DEGs which also be identified as hub genes according to Kwithin. Finally, the Nephroseq online tool showed that the tubulointerstitial expression levels of PLG significantly positively correlated with the eGFR, while ITGB2, CTSS and CCL5 connected negatively to the eGFR. Conclusion: WGCNA is an efficient approach to system biology. By this procedure, the present study improved the understanding of the transcriptome status of renal tubulointerstitial injury in CKD.
Virtual Implant Rehabilitation Of The Severely Atrophic Maxilla: A Radiological Study
Authors: Manacorda Michele , Chaurand Bianca Poletti de , Merlone Alberto , Tetè Giulia , Capparè Paolo , Vinci Raffaele
Published: November 2019

Background: Advanced maxillary atrophy is often observed and implant placement could become difficult. Nevertheless, a volumetric evaluation using a proper diagnostic software could facilitate the implant planning. The purpose of the present study is to suggest the potential application of the maxillary retro-canine area as the designated place for virtual tilted implants also in severely atrophic maxillae. Methods: A sample of CBCT images from the Department of Dentistry (IRCCS San Raffaele, Milan) was evaluated. After a 3D anatomical evaluation of the maxilla tilted implants has been virtually positioned in the retro-canine regions. All the implants were inserted with the same procedure at 30° and 45° degrees of tilting. The length, the palatal angulation and the diameter of each implant were identified. Results: 220 tilted implants were placed. An average implant measurement of 13.508 mm of length and 3.42 mm of diameter were calculated. Also, an average buccal-palatal angulation of 6° was identified. After the statistical analysis implant length was found significantly higher at 45° degrees than at 30° degree (<0.0001).Conclusions: A considerable amount of patients show a significant degree of bone atrophy. The implant-supported treatment plan can rely on the three dimensional imaging of the residual bone as a guiding tool to establish the most effective implant position for each specific case. In this study it is founded that an implant could be longer if its mesio-distal angulation is more accentuated. In addition, it is possible to virtually insert tilted implants also in severely atrophic maxilla. This could help clinicians to consider the retro-canine area a viable place to insert longer tilted implant.
Generation of hepato-biliary-pancreatic organoid from human pluripotent stem cells
Authors: Koike Hiroyuki , Iwasawa Kentaro , Takebe Takanori
Published: November 2019

Organogenesis is a complex and inter-connected process, orchestrated by multiple boundary tissue interactions. Here, we established the protocol of the continuous patterning of hepatic, biliary and pancreatic structures from a three-dimensional culture of human pluripotent stem cell (PSC). The boundary interactions between anterior and posterior gut spheroids differentiated from human PSCs enables autonomous emergence of hepato-biliary-pancreatic (HBP) organ domains in the absence of extrinsic factor supply. This anterior-poterior gut interaction protocol can be used to model the early human HBP organogenesis process in vitro.
Data quality of drug-resistant tuberculosis and antiretroviral therapy electronic registers in South Africa
Authors: Jamieson Lise , Evans Denise , Berhanu Rebecca , Ismail Nazir , Aucock Samantha , Wallengren Kristina , Long Lawrence
Published: November 2019

Background To assess the quality and completeness of treatment and outcome data in the electronic tuberculosis (TB) and antiretroviral treatment (ART) registers in drug-resistant (DR-) TB patients at three treatment facilities in South Africa. Methods We did a retrospective cohort study using routinely-collected data from DR-TB registers of rifampicin resistant adults (≥18 years old), on ART, initiating DR-TB treatment between January 2012 and December 2013. We linked patient information from the DR-TB register to the ART register using patient identifiers and an algorithm based on string edit distance and date of birth. We describe data gaps and discrepancies found. Results Overall, 2,852 DR-TB patients met our inclusion criteria based on the DR-TB register data, and of these, 1,685 (59%) could be matched to the ART registers. An additional 253 patients from the DR-TB registers were found in the ART registers, having initiated ART, despite the DR-TB register indicating that they were not on ART (or this data was missing). 11% of matched patients did not have TB treatment status recorded in the ART register despite being recorded as being on TB treatment in the DR-TB register, and 78% did not have an ART start date recorded in DR-TB register despite being on ART treatment as per the ART register. 11% of matched patients had a death recorded in one register but not the other, and of those with death recorded in both, 15% of dates differed by >1 month. Conclusions The underreporting of death and the lack of ART or TB status in the electronic DR-TB and ART registers could negatively impact monitoring efforts by downplaying the state of the TB/HIV epidemic. Improved recording of these data sources, and data integration across systems, could improve the accuracy of reporting for the national HIV/ART and TB programs.
Asthma in children treated with paracetamol versus ibuprofen: A systematic review and meta-analysis of randomised controlled trials
Authors: Sherbash Mohamed , Furuya-Kanamori Luis , Nader Joanne Daghfal , Thalib Lukman
Published: November 2019

Background:
Paracetamol and ibuprofen are the most commonly used medications for fever and pain management in children. While the efficacy appears similar with both drugs, there are contradictory findings related to adverse events. In particular, incidence of asthma among children taking paracetamol compared to ibuprofen, remain unsettled.
Methods:
We conducted a meta-analysis of randomized controlled trials (RCTs) that compared asthma in children taking paracetamol versus ibuprofen. A comprehensive search was conducted in five databases. RCTs reporting on cases of asthma in infants or children after the administration of paracetamol or ibuprofen were included. The pooled effect size was estimated using the inverse variance heterogeneity model.
Results:
Five RCTs with 85095 children were included in the analysis. The pooled estimate (RR 1.04; 95%CI 0.84-1.29) revealed no difference in the risk of developing asthma or presenting an exacerbation of asthma in children who received paracetamol compared to ibuprofen. When the analysis was restricted to RCTs that examined the incidence of asthma, the pooled estimate remained similar (RR 1.03; 95%CI 0.64-1.67). Additional bias adjusted quality effect sensitivity model yielded similar results (RR 1.03; 95%CI 0.84-1.28).
Conclusion:
Although, Ibuprofen and paracetamol appear to have similar tolerance and safety profiles in terms of incidence of asthma in children, we suggest high quality trials with clear definition of asthma outcomes after receiving ibuprofen or paracetamol at varying doses with longer follow-up are warranted for any conclusive finding.
A Method to Adjust for Measurement Error in Three Exposures Measured with Correlated Errors in the Absence of Internal Validation Study
Authors: Muoka Alexander K. , Agogo George , Ngesa Oscar , Mwambi Henry
Published: November 2019

Difficulty in obtaining the correct measurement for an individual's long-term exposure is a major challenge in epidemiological studies that investigate the association between exposures and health outcomes. Measurement error in an exposure biases the association between the exposure and a disease outcome. Usually an internal validation study is required to adjust for exposure measurement error; it is challenging if such a study is not available. We proposed a method (trivariate method) that adjusts for measurement error in three correlated exposures in the absence of internal validation study and illustrated the method using real data. We compared the results from the proposed method with those obtained using a method that ignores measurement error and a method that ignores correlations between the errors and true exposures (the univariate method). It was found that ignoring measurement error leads to bias and underestimates the standard error. It was also found that the magnitude of adjustment in the trivariate method is sensitive to the magnitude of measurement error, sign and correlation between the errors. We conclude that the proposed method can be used to adjust for bias in the outcome-exposure association in a case where three exposures are measured with correlated errors in the absence of an internal validation study. The method is useful in conducting a sensitivity analysis on the magnitude of measurement error and the sign of the error correlation.