bluuebunny/crossref_metadata_2025 huggingface dataset:
Managing the Stable Development of Manufacturing Systems under Decentralization
Authors: Usov Anatoly , Kunitsyn Maksym , Zabarna Eleonora , Niekrasova Liubov
Published: December 2023

This article provides an overview of the arguments and counterarguments involved in identifying the state of an enterprise, assessing its functional efficiency, and optimizing its target functions while implementing management tasks. The decentralization of enterprises empowers them to adapt to specific territorial needs. However, it also introduces an element of instability that can be disconcerting. The primary objective of this research is to develop a scientific and methodological approach to modelling the management system of the development of manufacturing enterprises under decentralization. The systematization of literary sources and approaches to the problem of managing the development of manufacturing enterprises reveals that each level of analysis of the state of the enterprise and assessment of its development dynamics and problem situation corresponds to the aggregate set of assessments, which includes both individual indicators and their various groups. At its core lies the crucial recognition of production systems’ (PS) state as a pivotal parameter influencing the very fabric of UTC development. The model employs a powerful vector functional approach, allowing for a multi-dimensional assessment of an enterprise’s state. The model translates into a tangible metric, empowering informed decision-making and targeted interventions. The relevance of this scientific problem is that the management process of enterprise development under decentralization needs to be more structured and less accidental. There is a need to manage this process to survive and develop in an aggressive market environment. Optimal management of production systems as discrete matrix objects provides an opportunity to consider the functioning of each of them depending on the state of the others at time t of their production to time t+1, which is associated with their further development in a decentralized environment. The results of the research can be helpful for the development of systems for monitoring and strategic management of the development processes of manufacturing enterprises under decentralization.
Demographic Differences in United States Consumers’ Perceptions and Willingness to Pay for Sustainable Environmental Practices in the Floral Industry
Authors: Etheredge Coleman L. , Waliczek Tina M. , DelPrince James
Published: December 2023

Consumers have become increasingly concerned about the environmental standards of industries from which they purchase products. Because consumers’ environmental concerns are increasingly becoming part of their purchasing decisions, industries have begun to restructure their business model to one that is more environmentally sustainable. Studies have indicated consumers’ actions and motivations for purchasing sustainable products vary based on consumer demographics. The main purpose of this study was to compare the differences in consumers’ perceptions and willingness to pay as they relate to retail floral providers’ sustainable and environmentally sound practices based on demographic traits. A total of 2172 people responded to an online survey. The sample used in this study was a random selection of individuals 18 years of age or older living in the United States. Survey responses were collected from 21 Dec 2022 to 27 Jan 2023. Data were analyzed using analyses of variance and post hoc tests as well as descriptive and frequency statistics. Results indicated there was a difference in the way respondents answered the survey questions based on demographics. Respondents 34 years of age or younger with college experience indicated the most willingness to make purchases and pay premiums from floral providers that incorporate sustainable attributes into their business model. Males indicated a stronger willingness to shop at a floral provider based on several of the environmental statements when compared with other genders. The results provide evidence of the value of the integration of sustainability practices into the business model of floral providers to make it more competitive.
Implications of current validity frameworks for classroom assessment
Authors: MOR Ezgi , KARATOPRAK ERŞEN Rabia
Published: December 2023

The argument-based approach is the current framework for validity and validation. One of the criticisms is that understanding and applying this approach to practice are complicated and require abstract thinking. Teachers or school administrators in teaching and learning need support in their validation practice. Due to the abstract structure of validity, the test users and instructors who are not familiar with psychometrics may face problems in gathering validity evidence. Especially in classroom assessment, teachers may deal with understanding the complex methods of validation. In line with this need, the purpose of this study is to help instructors validate their assessment practices by providing a pathway to guide them through their validation processes and to make the validation process more obvious in classroom assessment. For this purpose, a checklist including the validity indicators for classroom assessment is developed. In this development process, Sireci's (2020) 4-step validation which is based on AERA et al. (2014) Standards and Bonner's (2013) study as a framework were followed. The validity indicators were composed by simplifying the AERA’s standards and the ones which are relevant to classroom assessment were selected. In addition to the standards, the aforementioned studies were investigated and the validity indicators that may be applicable in classroom assessment were determined.
Dilsel İfadelerin Mantıksal Örgüsü
Authors: YILMAZ Çağlayan
Published: December 2023

Dilsel ifadeler üzerine mantıksal bir çözümleme çabası olan bu yazıda dil bir iletişim dizgesi olarak ele alınmış, iletişim amaçlı üretilen deyimler olarak sözceler bileşenlerine ayrılmıştır. Edim ve önerme olmak üzere iki anlamsal bileşenden oluşan sözcelerin, önermesel anlamına odaklanılmıştır. Önermeleri oluşturan terimlerin birbirleriyle ve şeylerle kurduğu ilişkilerin mantıksal örgüsünün önermenin sözdizimine olan etkisi ortaya konmaya çalışılmıştır. Yasaları tanımlayan genel önermeler ile şeyleri betimleyen tekil önermeler olmak üzere iki temel başlıkta ele alınan önermeler tümevarım mantığıyla çözümlenmiştir. Önermeyi oluşturan ögeler olarak terimlerin şeylerle kurduğu uygulama ve adlandırma bağlantıları örnekler üzerinden gösterilmiş ve şeylere yapılan gönderimin koşulları tartışılmıştır. Tekil önermelerin cümle dışında farklı sözdizimleriyle ifade edilebildiğinin kanıtlanmaya çalışıldığı bu yazıda sözdizimsel kuruluşları aynı olan dilsel ifadelerin farklı mantık örgülerine sahip olabildiği gösterilmiştir. Sözdizimi ile mantıksal örgü arasındaki ilişki tamlamalar üzerinden tespit edilmeye çalışılırken yer yer ortaya çıkan aykırılıklara da dikkat çekilmiştir. Aynı önermesel anlama sahip farklı sözdizimlerindeki tekil önermeler için bir çözümleme yöntemi önerilmiş, kullanılan örnekler standart Türkçeden seçilmiştir.
Home, Physical Disability and Sense of Belonging in Nina Raine’s Tribes
Authors: ÇELİK Nurten
Published: December 2023

Home has traditionally been perceived as a location that provides control, freedom of self-expression, and psychological, social, and physical security. However, the presence and development of physical impairment subvert the positive aspects and conventional conceptions of home. Any corporeal attributes that challenge the culturally assumed views of the disabled body are rarely or never recognized as a part of domestic life. Home transforms into a site of oppression and discrimination as the denial of impairment in the sphere of the home leads to psychological and emotional disturbance and the distortion of a sense of belonging. One contemporary play that explores the complicated relationship between impairment, home, and culture is Nina Raine’s Tribes. Tribes dramatizes the ways in which the cultural understanding and treatment of disability shape and regulate the embodied experiences of the disabled character within the confines of home. Billy’s deafness is ignored by his family members, who do not acknowledge the existence of the deaf community, sign language, and deaf culture. Additionally, Billy experiences alienation and isolation in a family that wallows in miscommunication, disagreement, misunderstanding, and lovelessness. Therefore, this essay explores how the social norms concerning the disabled body operate to determine and govern the perception and validation of hearing impairment in a home setting by focusing on the emotional aspects of an embodied life. Furthermore, it explores how the pre-established notions of the body, hierarchy, and value create feelings of alienation and a lack of belonging.
Kapadokya Bizans Kiliselerinde “Boş Mezar Başında Kadınlar” Sahnesi
Authors: ÖNCELEN Gizem
Published: December 2023

Hristiyan teolojiside İsa’nın Dirilişi’ne işaret eden ilk sahne “Boş Mezar Başında Kadınlar” sahnesidir. Kronolojik olarak İsa’nın Gömülmesi’nden sonra ve Chairete’den önce gerçekleşmiş olan bu sahnenin ikonografisinde dört temel unsur karşımıza çıkar. Bunlar, taşıdıkları mür kaplarıyla İsa’nın mezarına gelen Mürlü Kadınlar (Myrophoroi), Mürlü Kadınları karşılayan bir melek, meleğin işaret ettiği kutsal mezar ve mezarın yanında duran askerlerdir. Kapadokya’da Mürlü Kadınlar iki veya üç kadınla temsil edilir. Teolojide adları Mecdelli Meryem, Yakup’un annesi Meryem ve Salome olarak geçer. Bazı Bizans kaynakları boş mezardaki kadınlar arasında Meryem Ana’nın da bulunduğuna dair atıfta bulunsa da bu durum Kapadokya resmine yansımamıştır. Sahnenin merkezinde bir melek, sağında ise kutsal mezar tasviri yer alır. Erken Hıristiyan sanatında İsa’nın mezarı genellikle rotond biçimlidir. Ancak Kapadokya örneklerinde edikül formun ağırlıklı olduğu görülür. Bununla birlikte erken Bizans örneklerinde İsa’nın mezarının boş olduğu vurgusu hacimli tasvir edilen mezar yapısıyla verilir. Kapadokya’da ise bunun yerini daha küçük bir mezar alır. Mezarı işaret eden melek ise merkezi konumda oldukça hacimli şekilde tasvir edilir.
Farklılığı Bedenselleştirmek: Sakatlık Deneyimleri Üzerine Fenomenolojik Bir Araştırma
Authors: ÖZİL Hüseyin
Published: December 2023

Bu çalışma, yeti yitimi yaşayan bireylerin sakatlık deneyimlerini fenomenolojik bir bakışla ortaya koymayı hedeflemektedir. Yeti yitiminin getirdiği bedensel değişimler çalışmanın ortaya koymaya çalıştığı hususların başında gelmektedir. Bu çerçevede çalışmada ortopedik ve görme engellerine sahip kişilerin sakatlığı bedenselleştirme durumları araştırılmıştır. Çalışmada ortopedik ve görme yeti yitimlerine sahip sakat kişilerin sakatlık algıları, sakatlık deneyimleri, gündelik hayat pratikleri, sakatlık algısının biçimleri, sakatlığı bedenselleştirme durumları incelenmiştir. Çalışmada nitel araştırma yöntemi benimsenmiştir. Nitel araştırma yöntemlerinden fenomenolojik desen kullanılmıştır. Saha çalışmasında ortopedik ve görme yeti yitimlerine sahip 40 katılımcıyla derinlemesine görüşmeler gerçekleştirilmiştir. Çalışmada, sakatlığın farklılığın farkındalığı ile başladığı gözlemlenmiştir. Bu farkındalık kişileri sosyal yaşamdan uzaklaştırmaktadır. Bu uzaklaşma sakat bireylerin yaşam seyrini değiştirmektedir. Ancak tüm bunlara karşın sakatlığın bir süre sonra normalliğe evrildiği görülmüştür. Sakatlık, zaman içerisinde bir normalliğe evrilse de toplumda bir dışlama biçimi olarak var olmaya devam etmektedir. Bu çerçevede sakatların bedensel deneyimleri fiziki beden, yaşanan beden, yaşam dünyası ve algılanan öteki başlıkları üzerinden analiz edilmiştir. Analiz sonucunda yedi temaya ulaşılmıştır. Bunlar; farklılığın farkındalığı, yaşam dünyası ve sakatlık, stratejik davranışın bedenselleştirilmesi, sakatlık ve teknolojiyle yaşam, sakat bedende yaşam seyri, bedenin yeni normalliği ve sakatlığın sıradanlığıdır. Sonuç olarak sakatlığın bedensel bilginin yönetim stratejileriyle alakalı olduğu görülmüştür.
Insurance market transparency research trends: Bibliometric analysis
Authors: Kuzior Aleksandra , Zakharkina Liudmyla , Kubaščikova Zuzana , Chentsov Victor , Lyeonov Serhiy
Published: December 2023

Transparency is a fundamental necessity for the insurance market in the modern fast-changing and digital world. The study aims to establish, based on bibliometric analysis, the research trends and subject areas of the insurance market transparency, including the impact of digital technologies, regulatory initiatives, and the internal policies of insurance companies. A bibliometric analysis of papers published in the journals indexed by the Scopus database for the years 1988–2023 was conducted to achieve this goal. Five clusters have been identified based on the analysis of the shared use of keywords, demonstrating the multidisciplinary nature of the research subject. They cover government regulation and risk management; ethics; technological innovations in increasing transparency; transparency of prices and costs in health insurance; and state medical insurance transparency. The analysis of insurance market transparency trends has allowed identifying four key stages of development: post-crisis regulatory mechanisms (2013–2016), Solvency II regulation effectiveness (2017–2019), transparency during the pandemic (2020–2021), and the impact of digital innovations since 2021. Spatial clustering made it possible to identify five groups of countries whose representatives are co-authors of research on insurance market transparency. The leading countries in research on insurance market transparency are the USA, the UK, and Germany.
AcknowledgmentThis research was funded by the Ministry of Education and Science of Ukraine (projects No. 0122U000774 “Digitalization and transparency of public, corporate and personal finance: the impact on innovation development and national security”, No. 0123U101945 “National security of Ukraine through the prevention of financial fraud and money laundering: war and post-war challenges”). This research was funded under the research subsidy of the Faculty of Organization and Management of the Silesian University of Technology in Poland for the year 2023 (13/990/BK_23/0178).
Good governance: Role in the coherence of tax competition and shadow economy
Authors: Mazurenko Oleksiy , Tiutiunyk Inna , Grytsyshen Dymytrii , Daňo Ferdinand , Artyukhov Artem , Rehak Robert
Published: December 2023

The formation of the country’s tax competitiveness and countering the shadowing of the economy depend on several factors. One of them is an effective public administration. It defines state policy vectors, institutions’ critical tasks, and business and society development priorities. The aim of the paper is to analyze the impact of good governance on the country’s tax competitiveness and the level of the shadow economy of 11 EU countries and Ukraine in 2011–2021. The study employs statistical analysis of data series. It constructs a correlation field of points of relationship between indicators (to determine the general trends of changes in the level of the shadow economy, tax competitiveness, and the Good Governance Index). Linear mathematical model and Fishburn formula are used to construct an integral indicator of the level of efficiency of public management (Good Governance Index). Structural modeling methods formalize the influence of government management on the level of the shadow economy and tax competitiveness. It was found that the Government Efficiency Index and the Corruption Control Index exert the most significant correlation with the level of tax competitiveness and the shadow economy. Its increase of 1% leads to a rise in the level of tax competitiveness of Slovakia by 7.015%, Croatia by 6.889%, the Czech Republic by 6.606%, and Romania by 5.773%. At the same time, the smallest correlation with the level of tax competitiveness performs an Index of Political Stability and Absence of Violence/Terrorism.
AcknowledgmentThe study is funded by the project VEGA – 1/0392/23 “Changes in the approach to the creation of companies’ distribution management concepts influenced by the effects of social and economic crises caused by the global pandemic and increased security risks.”The authors are grateful to the participants of projects 0123U101945 and 0122U000777 for numerous discussions and comments.
Social context of establishing criminal liability for interference in the activities of a state official
Authors: Maltseva Anastasiia
Published: December 2023

The concepts of "state" and "security" are closely related. The prospects for the development of statehood will largely depend on the ability of the state and society to create a system of security measures that is adequate to the level of threats.

The relevance of the topic lies in the fact that the proper functioning of the state requires proper activities of persons representing the highest levels of state power. In case of encroachment or direct intervention in their activities, this can threaten national security. Therefore, this issue is relevant and requires detailed consideration.

It is necessary to ensure effective, comprehensive interaction between state authorities. For this purpose, the effectiveness of the performance of official duties by officials of the highest state authorities to the full extent and without possible interference in their activities arises. The state is obliged to ensure proper protection of such persons, including at the regulatory and legal level.

The purpose of the article is to investigate the grounds for establishing criminal liability for a specific criminal offense provided for in Article 344 of the Criminal Code of Ukraine and to clarify whether the existence of the aforementioned criminal prohibition is socially conditioned.

To achieve the stated goal, this scientific work analyzes the norms of the law on the issue of criminal liability for interference in the activities of a state official.

The author characterizes the concept of criminalization of an act and examines the grounds and principles for establishing criminal liability for this criminal offense. The issue of the social conditioning of the criminal-legal norm and the circumstances that led to its adoption is investigated. Statistical data for the period from 2015 to 2021 are considered.

As a result, it is concluded that the criminalization of an act that involves interference in the activities of a state official is socially conditioned and necessary to ensure the proper functioning of the state and national security.
Intentional introduction into circulation on the market of Ukraine (releasing on the market of Ukraine) of dangerous products: problems of defining and establishing mandatory signs of this criminal offense
Authors: Plaksiuk Inna
Published: December 2023

The article is devoted to the study of current problems of legal definition and establishment of mandatory elements of the criminal offense (crime) provided for in Article 227 "Deliberate introduction into circulation on the market of Ukraine (release on the market of Ukraine) of dangerous products" of the Criminal Code of Ukraine. Mandatory signs of the objective side of the investigated criminal offense have been established. Attention is focused on the moment of the end of the crime.

The expediency of improving Article 227 of the Criminal Code of Ukraine by including in its provision a socially dangerous consequence of alternative types, as well as by adding part 2 of the specified article with circumstances aggravating criminal liability for the analyzed criminal offense, is substantiated. Such circumstances are recognized as the repeated commission of an act either by prior conspiracy by a group of persons or with the occurrence of serious consequences, or by an official using his official position.
Collaboration activities in the form of public calls and denials of armed aggression against Ukraine: practice of application
Authors: Kozachenko Oleksandr Vasylovych , Musychenko Olha Mykhailivna
Published: December 2023

The article is devoted to the scientific analysis of certain problems of criminal legal qualification for collaboration activities under Part 1 of Art. 111-1 of the Criminal Code of Ukraine. The author makes a criminal law analysis of this provision as one of the manifestations of collaboration activity which is criminalized in law. Some problems of qualification are considered, related to the need to distinguish between the provisions of Part 1 of Article 111-1 of the Criminal Code of Ukraine of Ukraine and parts 1 and 2 of Article 436-2 of the Criminal Code of Ukraine. The article analyzes the court decisions under Part 1 of Article 111-1 of the CC of Ukraine, and certain problems regarding application of this provision in practice, and based on this, a number of conclusions and  the author's proposals were formulated. The authors point out certain flaws in the wording of Art. 111-1 of the CC of Ukraine, and associate this with the lack of the necessary scientific justification for the allocation of substantive features of collaboration activities, which the legislator would rely on when criminalizing this type of socially dangerous act. The study argues that acts in the form of public calls for illegal elections and/or referendums should be classified as criminal offenses, namely to define this form in Part 1 of Art. 111-1 of the Criminal Code of Ukraine, given that public calls, public objections are not manifestations of collaborationism in the classical understanding as cooperation with the enemy under occupation. On the basis of the studied criminal proceedings, the ineffectiveness of the application of a single punishment in the form of deprivation of the right to hold certain positions and engage in certain activities. Therefore, it is proposed to provide for alternative penalties in parts 1 and 2 of Art. 111-1 of the Criminal Code of Ukraine to provide for alternative penalties in the form of a penalty and public services.
A sign that aggravates responsibility and affects the qualification of a criminal offense: legal nature and concept
Authors: Us Olha Volodymyrivna
Published: December 2023

The relevance of the research topic is due to the complexity of the problem of differentiation of criminal law regulation and individualization of criminal law influence, which necessitates the need for scientific development and clarification of the legal nature, concept, terminological designation and functional purpose of a sign that burdens responsibility and affects the qualification of a criminal offense (qualifying signs). General scientific and special methods of scientific research, chosen taking into account the subject, goal and tasks of scientific work, determined the achievement of a scientific result.The legal nature of the sign that burdens responsibility and affects the qualification of a criminal offense has been established. The positions expressed in the criminal law literature, which is devoted both to the question of the composition of a criminal offense and to the study of individual compositions of criminal offenses, regarding the understanding of the essence of such a sign and its concept are analyzed. The meaning of the concept of "a sign that burdens responsibility and affects the qualification of a criminal offense" has been clarified. On the basis of the conducted research, the main properties (characteristics) of the sign that burdens responsibility and affects the qualification of a criminal offense have been clarified and formulated. The names of the characteristics under investigation proposed in the scientific literature were analyzed. A proposal has been made regarding the terminological designation of a sign that burdens responsibility and affects the qualification of a criminal offense.The research will serve as a scientific basis for the further resolution of both complex debatable issues of criminal law doctrine regarding the issue of the composition of a criminal offense, as well as the practice of criminal law regulation (legislation) and the criminal law qualification of offenses provided for by the qualified composition of criminal offenses.
Örgütsel Muhalefet Davranışları Ölçeği: Geçerlik ve Güvenirlik Çalışması
Authors: Iliman Püsküllüoğlu Elif , Duman Ahmet
Published: December 2023

Bu çalışmanın amacı muhalefet davranışlarının ölçülmesini sağlayacak geçerli ve güvenilir bir ölçme aracı geliştirmektir. Bu amacı gerçekleştirmek üzere 2020-2021 yılı eğitim öğretim döneminde bahar yarıyılında öğretim elemanlarından veri toplamıştır. Ölçeğin yapı geçerliği için açımlayıcı ve doğrulayıcı faktör analizleri gerçekleştirilmiştir. Açımlayıcı faktör analizi sonucu dört faktörlü bir yapı ortaya çıkmıştır. Seslilik, Muhalif Eylemler, Pasif Tepkiler ve Politik Taktikler olarak ölçeğin boyutları isimlendirilmiştir. Ortaya çıkan dört faktörlü yapı toplam varyansın %56.29’unu açıklamaktadır. Ölçekte yer alan 23 madde 1-Hiçbir zaman ve 5-Her zaman aralığında puanlanmaktadır. Ölçeğin sadece ilk maddesi terstir. Ölçeğin bir boyutundan ya da ölçekten alınan toplam puanın artması, muhalefet davranışının arttığı anlamına gelmektedir. Ölçeğin 23 maddelik ve dört faktörlü yapısı doğrulayıcı faktör analizi ile de test edilmiştir. Doğrulayıcı faktör analizinde χ2/sd oranı 1.97 (433.57/ 219) ve diğer uyum iyiliği değerleri RMSEA=.05, NFI=.85, NNFI=.90, CFI=.91, IFI=.92, GFI=.88, RMR=.08, SRMR=0.07. olarak bulunmuştur. Ölçeğin güvenirliğine ilişkin, madde toplam korelasyonları, Cronbach’s Alpha güvenirlik katsayısı, alt ve üst %27’lik grupların madde toplam korelasyonları incelenmiştir. Sonuç olarak, öğretim elemanlarının örgütsel muhalefet davranışlarını ölçmeye yönelik psikometrik olarak yeterli, geçerli ve güvenilir bir ölçme aracı geliştirilmiştir.
A Teacher’s Values Are Essential in Educating Children and Youth for Peace
Authors: Wiśniewska Ewa
Published: December 2023

Nauczyciel stanowi o jakości i efektywności procesu wychowania do pokoju w szkole. Istotą roli nauczyciela w wychowaniu do pokoju jest przede wszystkim dawanie dobrego przykładu swoją kulturą pokoju i pokazywanie własnym zachowaniem jak żyć moralnie. Na nauczycielach ciąży więc ogromna odpowiedzialność, gdyż wartości, jakimi kieruje się nauczyciel są fundamentalnymi dla młodego człowieka. Celem niniejszego wywodu jest namysł nad rolą nauczyciela w edukacji młodych pokoleń do pokoju oraz uzasadnienie imperatywnych w tym procesie wartości nauczyciela takich jak: tolerancja, dialog i przebaczenie
Teoria Martina Wighta jako kontekst interdyscyplinarności pedagogiki porównawczej
Authors: Bocharova Olena , Melnik Inessa
Published: December 2023

Podstawą do interpretacji pedagogiki porównawczej jako epistemu wiedzy naukowej stała się oryginalna praca International Theory: The Three Traditions, 1992 Martina Wighta, założyciela angielskiej szkoły teorii polityki międzynarodowej. Teoria społeczeństwa międzynarodowego opisuje trzy tradycje: realizm (lub makiawelizm), racjonalizm (horacjonizm) i rewolucjonizm (kantyzm). Niniejszy artykuł ma charakter przeglądowy i jest podzielony na dwie części, a treści w nim zawarte bazują na dostępnej literaturze przedmiotu. W części pierwszej przedstawiona została teoria społeczeństwa międzynarodowego oraz jej podstawowe założenia. Część druga prezentuje zmiany, które odbyły się w prowadzeniu i organizacji badań porównawczych. Zmiany te dotyczyły: przedmiotu badań np. państwa jako jednostki badawczej, działalności międzynarodowych organizacji (PISA, TIMSS), ich roli w rozwoju edukacji; rozpowszechnienia konkurencyjności wśród systemów edukacji; rozwoju globalizacji i jego wpływu na edukację.
Evolução do fator de potência em residências e suas implicações para o setor elétrico
Authors: Neiva Pinheiro Vinícius de Carvalho , Francato Alberto Luiz
Published: December 2023

Nas últimas décadas, os padrões de consumo de energia elétrica em residências no Brasil têm passado por mudanças, como a substituição de lâmpadas incandescentes por fluorescentes ou LED, popularização de eletrônicas e, em certa medida, popularização de aparelhos de ar-condicionado. Aparelhos que não são puramente resistivos consomem, além de energia ativa, energia reativa e, portanto, essas mudanças em aparelhos elétricos típicos de residências fizeram com que o consumo de energia reativa crescesse consideravelmente mais que o consumo de energia ativa, exigindo do sistema elétrico mais provimento desta energia reativa. Neste trabalho, foram feitas estimativas dessa mudança recente nos padrões de consumo de energia reativa em residências para avaliar seus impactos para o setor elétrico brasileiro. Os resultados mostram que formas mais detalhadas de medição e cobrança por energia elétrica em residências, com separação de consumo de energia ativa e reativa, por exemplo, podem ser mais justas para os consumidores, além de estimular um consumo que alivie a necessidade de provimento de reativos no sistema elétrico nacional.
Avanços e limitações da produção, armazenamento e transporte de hidrogênio verde
Authors: Dos Santos Puga Mariana , Olortiga Asencios Yvan Jesus
Published: December 2023

A busca por fontes limpas de energia e produção é um dos principais objetivos de países do mundo todo para a descarbonização da economia. Atualmente, diversas soluções estão sendo desenvolvidas para os problemas ambientais, sociais e econômicos relacionados às emissões dos gases de efeito estufa. O hidrogênio verde apresenta-se como uma das tecnologias promissoras para atender as demandas energéticas e de processos produtivos de diversos setores da economia. O hidrogênio é o elemento químico mais abundante da superfície terrestre e encontra-se normalmente associado a compostos orgânicos como hidrocarbonetos, além disso se encontra formando as moléculas de água. Entretanto, para obtê-lo de maneira isolada é necessário extraí-lo de fontes como água, petróleo, gás natural, biogás, entre outras. O hidrogênio verde é aquele produzido a partir da eletrólise da água com energia oriunda de fontes renováveis. Ainda existem alguns desafios a serem superados para efetivamente atender as demandas das indústrias de produção de fertilizantes, petrolíferas, metalúrgicas e abastecimento de energia elétrica. Sendo assim, este trabalho aborda os avanços e as limitações para produção, armazenamento e transporte de hidrogênio verde, bem como, a produção científica através de uma revisão sistemática de literatura. Para a produção, o custo de energia renovável foi relevante, considerando apenas energia fotovoltaica/compra. O mapeamento de outras opções pode tornar a análise abrangente. A eletrólise da água está associada a maturidade da tecnologia e o custo dos eletrolisadores, compostos por metais de alto valor agregado. Assim, é necessário o desenvolvimento de novos materiais. Em relação ao armazenamento, a viabilidade tecno econômica da operação é onerosa. Tecnologias que possam superar estes desafios podem otimizar a cadeia de suprimentos. Diversos estudos consideraram o uso da malha de dutos existente para o transporte. Entretanto, como países estão sendo considerados potenciais pólos de exportação, esperava-se encontrar artigos que abordassem o transporte para longas distâncias.
Recent Advancements in the Treatment of Alzheimer’s Disease: A Multitarget-directed Ligand Approach
Authors: Kumar Sumit , Mahajan Amol , Ambatwar Ramesh , Khatik Gopal L.
Published: December 2023

:

Alzheimer's disease (AD) is a neurodegenerative disease and one of the leading causes of progressive dementia, affecting 50 million people worldwide. Many pathogenic processes, including amyloid β aggregation, tau hyperphosphorylation, oxidative stress, neuronal death, and deterioration of the function of cholinergic neurons, are associated with its progression. The one-compound-one-target treatment paradigm was unsuccessful in treating AD due to the multifaceted nature of Alzheimer's disease. The recent develop-ment of multitarget-directed ligand research has been explored to target the complemen-tary pathways associated with the disease. We aimed to find the key role and progress of MTDLs in treating AD; thus, we searched for the past ten years of literature on “Pub-Med”, “ScienceDirect”, “ACS” and “Bentham Science” using the keywords neurodegen-erative diseases, Alzheimer’s disease, and multitarget-directed ligands. The literature was further filtered based on the quality of work and relevance to AD. Thus, this review high-lights the current advancement and advantages of multitarget-directed ligands over tradi-tional single-targeted drugs and recent progress in their development to treat AD.
The Role of Quercetin for the Treatment of Endometriosis and Endometrial Cancer: A Comprehensive Review
Authors: Chaichian Shahla , Nikfar Banafsheh , Arbabi Bidgoli Sepideh , Moazzami Bahram
Published: December 2023

Endometrial glands and stroma can be seen outside the uterine cavity in endometriosis,
a gynecological disorder linked to estrogen dependency. Hormonal therapies,
surgical excision, and non-steroidal anti-inflammatory drug therapy are among the
traditional endometriosis treatments, however, various side effects limit their efficacy.
Therefore, it is vital to research complementary and alternative therapeutic modalities to
decrease the side effects of conventional therapies. While the search for the best endometriosis
treatment continues, the focus is being paid to the assistance provided by polyphenols,
notably quercetin. A broad spectrum of health-improving benefits of
quercetin includes interactions with endometriosis-related molecular targets such as cell
proliferation, apoptosis, invasiveness, inflammation, and oxidative stress. According to
already-known research, medicines that mimic the physiological effects of quercetin are
good candidates for creating novel endometriosis therapies. This review aims to comprehensively
review quercetin's potential as a non-pharmacological treatment for endometriosis
by interacting with several cellular and molecular targets.
Vaccinomics: Paving the Way for Personalized Immunization
Authors: Al-Eitan Laith Naser , ElMotasem Moh’d. Fahmi Munib , Khair Iliya Yacoub , Alahmad Saif Zuhair
Published: December 2023

Vaccines are one of the most important medical advancements in human history. They have been
successfully used to control and limit the spread of many of the lethal diseases that have plagued us, such as
smallpox and polio. Previous vaccine design methodologies were based on the model of "isolate-inactivate inject", which amounts to giving the same vaccine dose to everyone susceptible to infection. In recent years,
the importance of how the host genetic background alters vaccine response necessitated the introduction of
vaccinomics, which is aimed at studying the variability of vaccine efficacy by associating genetic variability
and immune response to vaccination. Despite the rapid developments in variant screening, data obtained from
association studies is often inconclusive and cannot be used to guide the new generation of vaccines. This review aims to compile the polymorphisms in HLA and immune system genes and examine the link with their
immune response to vaccination. The compiled data can be used to guide the development of new strategies
for vaccination for vulnerable groups. Overall, the highly polymorphic HLA locus had the highest correlation
with vaccine response variability for most of the studied vaccines, and it was linked to variation in multiple
stages of the immune response to the vaccines for both humoral and cellular immunity. Designing new vaccine technologies and immunization regiments to accommodate for this variability is an important step for
reaching a vaccinomics-based approach to vaccination
Aromatic Plants as Potential Resources to Combat Osteoarthritis
Authors: Maring Maphibanri , C. Balaji , M. Komala , Nandi Sisir , S. Latha , H. Balaji Raghavendran
Published: December 2023

Osteoarthritis, which affects an estimated 10% of men and 18% of women over the
age of 60 and is increasing in genetic prevalence and incidence, is acknowledged as the condition
that degrades the quality of life for older adults in the world. There is currently no known
treatment for osteoarthritis. The majority of therapeutic methods slow the progression of arthritis
or treat its symptoms, making effective treatment to end the degenerative process of arthritis elusive.
When non-pharmacological therapy is ineffective, various pharmacological therapies may
be used to treat osteoarthritis. Pharmacological therapy, however, can have major adverse effects
and be very expensive. As a result, alternative remedies have been researched. The promise for
the safe and efficient management of osteoarthritis has been demonstrated by herbal remedies.
Experimental research suggests that herbal extracts and compounds can reduce inflammation,
inhibit catabolic processes, and promote anabolic processes that are important for treating osteoarthritis.
Due to their therapeutic and innate pharmacological qualities, aromatic herbs are frequently
employed as herbal remedies. Recent research has shown that aromatic plants have the
potency to treat osteoarthritis. Additionally, complex mixtures of essential oils and their bioactive
ingredients, which have anti-inflammatory and antioxidant properties and are obtained from
aromatic plants, are frequently utilized as complementary therapies for osteoarthritis. To establish
new study avenues, the advantageous anti-osteoarthritic effects of aromatic herbal medicines,
including plants, essential oils, and their bioactive components, are extensively discussed.
Antianemic Activity of Allolobophora caliginosa Extract against
Phenylhydrazine-induced Anemia in Rats
Authors: Ahmed Nevien S. , Baiomy Ahmed A.A. , Mohamed Ayman S. , Fahmy Sohair R. , Ahmed Kawkab A. , Elbatran May M.
Published: December 2023

Background::

Anemia is a global hematological disorder. Earthworms have antimicrobial,
antispasmodic, antihypertensive, antiallergic, anti-inflammatory, and anticoagulant properties.

Objective::

Our study aimed to investigate the anti-anemic activity of the earthworm Allolobophora
caliginosa extract (AcE) on phenylhydrazine-induced hemolytic anemia in rats.

Methods::

Eighteen adult male albino rats were randomly divided into 3 groups (n = 6 per group)
as follows: Control, PHZ, and AcE-treated groups. Induction of anemia was done by intraperitoneal
administration of phenylhydrazine (40 mg/kg) for 2 consecutive days. Treatment of AcE by
intraperitoneal injection (45 mg/kg) for six successive days.

Results::

Treatment of anemic rats with AcE extract caused significant increases in red blood cells
(RBCs), hemoglobin (HB), hematocrit (HCT), total protein (TP), albumin, glutathione reduced
(GSH), catalase (CAT), and glutathione-S-transferase (GST), as compared to the PHZ group.
While, mean corpuscular haemoglobin (MCH), mean corpuscular hemoglobin concentration
(MCHC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase
(ALP), malondialdehyde (MDA), and nitric oxide (NO) levels significantly decreased after intraperitoneal
administration of AcE, when compared to the PHZ group. Liver sections from the AcEtreated
group restored the normal micromorphological features of the liver. The expression of caspase-
3 was weak and/or there was no expression in the liver sections from AcE groups. AcE caused a
significant reduction in the incidence of DNA damage, which appeared as less DNA in the tails.

Conclusion::

The present research sheds light on the antianemic efficacy of AcE in rats. This
study reveals that AcE has antianemic activity, which can be linked to its iron and branched-chain
amino acid content, as well as antioxidant and anti-apoptotic properties.
Introduction of Various Models of Palliative Oncology Care: A Systematic
Review
Authors: Arian Mahdieh , Hajiabadi Fatemeh , Amini Zakiyeh , Oghazian Mohammad Bagher , Valinejadi Ali , Sahebkar Amirhossein
Published: December 2023

Background:

The aim of this study is to synthesize the existing evidence on various
palliative care (PC) models for cancer patients. This effort seeks to discern which facets of PC
models are suitable for various patient cohorts, elucidate their mechanisms, and clarify the
circumstances in which these models operate.

Methods:

A comprehensive search was performed using MeSH terms related to PC and cancer
across various databases. The Preferred Reporting Items for Systematic Reviews and a
comprehensive evidence map were also applied.

Results:

Thirty-three reviews were published between 2009 and 2023. The conceptual PC
models can be classified broadly into time-based, provider-based, disease-based, nurse-based,
issue-based, system-based, team-based, non-hospice-based, hospital-based, community-based,
telehealth-based, and setting-based models. The study argues that the outcomes of PC encompass
timely symptom management, longitudinal psychosocial support, enhanced communication, and
decision-making. Referral methods to specialized PC services include oncologist-initiated
referral based on clinical judgment alone, via referral criteria, automatic referral at the diagnosis
of advanced cancer, or referral based on symptoms or other triggers.

Conclusion:

The gold standard for selecting a PC model in the context of oncology is a model
that ensures broad availability of early PC for all patients and provides well-timed, scheduled,
and specialized care for patients with the greatest requirement.
In-vitro Augmentation of Mesenchymal Stem Cells by Using Adult Bovine
Serum
Authors: Shehzadi Somia , Javed Maryam , Ullah Asmat , Bilal Waqar Ahmad , Iftikhar Shah Fatima , Ullah Sajjad
Published: December 2023

Background:

Umbilical cord mesenchymal stem cells (UC-MSCs) are increasingly being
utilized for immune-related disease therapies due to their low immunogenicity. However, the
primary culture of UC-MSCs requires the supplementation of serum in the growth medium, which
has posed a challenge due to ethical issues related to the collection method of the fetal bovine
serum (FBS) that is routinely used in cell culture.

Aim:

In order to address this, the purpose of this research was to assess the effectiveness of adult
bovine serum (ABS) as a different and more affordable source of serum for the in-vitro cultivation
of UC-MSCs. UC-MSCs were isolated from the umbilical cord of Wharton’s jelly of cow immediately
after birth, by digestion with Collagenase type I.

Method:

ABS was collected from fresh bovine sources and heat-inactivated. The morphology of
UC-MSCs was observed under an inverted microscope, and growth patterns, proliferative index,
and doubling time were calculated every two days to compare the efficacy of ABS with FBS. Immunocytochemistry
for specific markers was also conducted on the MSCs.

Result:

The results showed a notable difference in morphology, growth rate, population doubling,
and proliferative index between ABS and FBS.

Conclusion:

Intriguingly, ABS proved to be an effective supplement in the growth medium for expanding
UC-MSCs in vitro, providing a viable alternative to FBS.
A Review on the Neuroanatomy of Bee Brain and Social Behavior
Authors: Nongkhlaw Ridahunlang
Published: December 2023

At present, there is a growing interest among researchers in studying the structure and function of the bee brain in relation to their cognitive
behavior. The bee brain, despite its small size of approximately 1 million neurons, is known for its ability to facilitate effective communication and
collaboration. Just like humans, the bee brain is also controlled by biogenic amines like dopamine, serotonin and tyramine, octopamine, and
histamine. The honey bees communicate with each other by using a complex language called the “waggle dance”. Despite existing knowledge
about the bee brain's neuroanatomy, there is still a need to understand which specific regions control cognition and social behavior in bees. This
review aims to explore the different major parts of the bee brain and how each part contributes to modulating social behavior.
Tacrolimus Pharmacotherapy: Infectious Complications and Toxicity in
Organ Transplant Recipients; An Updated Review
Authors: Tolou_Ghamari Zahra , Palizban Abbas Ali
Published: December 2023

Background:

After allogeneic organ transplantation, in order to reduce the risk of rejection, tacrolimus is given. In fact, infection is reported as one of the most common side effects of tacrolimus that
might be associated with graft failure.

Objective:

This study aims to review the association between the occurrence of infections due to toxicity
following the administration of tacrolimus in organ transplant recipients.

Methods:

Scientific literature on the pharmacotherapy of tacrolimus after organ transplantation, infections,
and neurotoxicity were searched using PUBMED.Gov (https://pubmed.ncbi.nlm.nih.gov/), Web of Science,
and Scopus (n=108). All articles were screened, and the data associated with the topic of interest was extracted. The primary outcome was infection and neurotoxicity.

Results:

Total area under the curve exposure, the ratio of parent drug/metabolites of tacrolimus was reported to be correlated with aggressive events such as infection episodes. A trough/dose ratio may demonstrate
the net state of immunosuppression and drug-related events. The most frequent infectious complication of
tacrolimus after organ transplantation was reported as urinary tract infections (UTIs). Virulent strains of
recombinant Listeria monocytogenes, in addition to an increase in bacterial burden in the liver and spleen
tissues, were reported in experimental animal studies. Patient survival was significantly lower in recipients
with UTIs in the first post-transplant month. A higher degree of immunosuppression was associated with
recurrent UTIs and drug-resistant organisms. By inhibiting the cerebral immune system, tacrolimus could
cause neurodegeneration.

Conclusion:

Transplant type, gut dysmotility, acute or chronic condition before transplant surgery, use of
azole, antifungal, hematocrit, tacrolimus methods of detection, the total area under the curve, and duration
of hospital stay could define the risk of infection through the first month of transplant surgery. In addition,
neurological and infectious complications could be associated with the higher amounts of tacrolimus trough
levels (C0). Polypharmacy based on tacrolimus, antiviral, and antifungal drugs, in addition to neurotoxicity,
could increase the risk of opportunistic infections such as cytomegalovirus within the first year of organ
transplantation.
Cognitive Inherent SLR Enabled Survey for Software Defect Prediction
Authors: Mishra Anurag , Sharma Ashish
Published: December 2023

Introduction::

Any software is created to help automate manual processes most of the
time. It is expected from the developed software that it should perform the tasks it is supposed to do.

Methods::

More formally, it should work in a deterministic manner. Further, it should be capable of
knowing if any provided input is not in the required format. Correctness of the software is inherent
virtue that it should possess. Any remaining bug during the development phase would hamper the
application's correctness and impact the software's quality assurance. Software defect prediction is
the research area that helps the developer to know bug-prone areas of the developed software.

Results::

Datasets are used using data mining, machine learning, and deep learning techniques to
achieve study. A systematic literature survey is presented for the selected studies of software defect
prediction.

Conclusion::

Using a grading mechanism, we calculated each study's grade based on its compliance
with the research validation question. After every level, we have selected 54 studies to include in
this study.