bluuebunny/crossref_metadata_2025 huggingface dataset:
Representasi Pemimpin Wanita Melalui Visual Branding @ElevateWoman
Authors: Asima Oktavia Sitanggang  , Imaddudin
Published: May 2024

Ekonomi kreatif menjadi angin segar sekaligus kendaraan besar bagi Indonesia untuk bangkit di masa pandemi Covid-19. Ekonomi kreatif mengutamakan kreativitas, pengetahuan dan ide sebagai aset produksi. Salah satu program peningkatan industri kreatif di media sosial yang dikembangkan oleh salah satu Staf Khusus Presiden Republik Indonesia, Putri Tandjung, adalah program @ElevateWoman. @ElevateWomen adalah program dengan tagline “Bring More Women into the Room” yang didukung oleh Northstar Group, mengundang pengusaha wanita di 10 sektor industri kreatif untuk mendaftar dan berkesempatan untuk melenggang mendapatkan investasi dari investor terpilih. Penelitian ini bertujuan untuk mendeskripsikan representasi kepemimpinan wanita melalui visual branding pada program @ElevateWoman yang dipromosikan di Instagram dengan Putri Tandjung sebagai drafternya. Penelitian kualitatif deskriptif ini menggunakan metode semiotika sosial. Hasil penelitian menunjukkan bahwa tampilan visual yang dominan di media sosial @ElevateWoman dengan warna pastel dan biru muda-ungu, ilustrasi sederhana yang menggabungkan gambar bunga dan wanita mewakili karakter khas wanita di industri kreatif yang setia dan gigih. Hal ini tidak terlepas dari kemampuan wanita untuk membangun dan memelihara hubungan jangka panjang, kemampuan berkomunikasi secara efektif, kepekaan terhadap perbedaan budaya dan perilaku yang sesuai, kemampuan berorganisasi, dan perilaku yang tidak mengancam dan tidak agresif. Selain itu, peran Putri Tandjung sebagai influencer berdampak pada followers dalam program @ElevateWoman yang menguntungkan investor dari event Putri Tanjung (Entrepreneur dan CEO CXO CT Corp), Gita Wirjawan (Founder Ancora Group), Aldi Haryopratomo (Ex CEO Gopay dan Co-CEO). Founder Mapan), Setyanto Hantoro (CEO Telkomsel), Ajeng Sekar Putih (CFO BRI Ventures), dan Neneng Goenadi (Managing Director Grab Indonesia) serta mendukung popularitas dan personal branding Putri Tandjung sebagai wanita milenial, penggagas event dan pemerhati kesetaraan wanita di industri kreatif.
Manajemen Komunikasi Komunitas Pemuda Peduli Lingkungan (KPPL) Dalam Pengembangan Destinasi Wisata Situ Rawa Gede Bekasi
Authors: Imaddudin  , Darin Sekar Ardina  , Herlin Anintia
Published: May 2024

Dibalik kota Bekasi yang padat dengan industri, suatu Komunitas memberdayakan lingkungan yang terbilang kumuh penuh dengan limbah untuk dijadikan sebuah tempat wisata di pusat kota metropolitan. Tujuannya adalah mengetahui komunikasi strategis KPPL dalam mengembangkan sebuah wilayah yang terbilang kumuh menjadi sebuah destinasi wisata pilihan masyarakat. Penelitian ini dengan pendekatan kualitatif deskriptif melalui wawancara mendalam menggali informasi dengan bertujuan mendekripsikan dan menganalisis terkait masalah tersebut. Hasilnya dibuktikan dengan komunikasi strategis yang tertuang dalam POAC (planning, Organizing, Actuating, and Controlling) mampu memetakan potensi wisata dari lingkungan yang kumuh ditengah industri yang dikelola oleh Komunitas Pemuda Peduli Lingkungan (KPPL) dengan pendekatan direktif dan nondirektif yang mampu menjadikan pariwisata yang memperhitungkan aspek keberlanjutan lingkungan, sosial, budaya, dan ekonomi.
Penggunaan Media Sosial Facebook Sebagai Sarana Komunikasi dan Informasi di Kalangan Remaja (Studi Deskriptif pada Remaja di Alamanda Regency Blok M.5 RT 005/027)
Authors: Annisa Eka Syafrina  , Muhammad Rifai Alfarisi
Published: May 2024

Perkembangan teknologi informasi dan komunikasi menghasilkan media baru dalam proses interaksi dan komunikasi yang kemudian dimanfaatkan manusia di berbagai bidang. Saat ini, era media komunikasi interaktif membawa kita pada pengenalan terhadap dunia internet dengan berbagai program menarik yang disediakan, salah satunya adalah Facebook. Penelitian ini bertujuan untuk mengetahui bagaimana penggunaan media sosial Facebook sebagai sumber informasi di kalangan remaja. Dengan menggunakan metode penelitian kualitatif dengan jenis deskriptif, peneliti melakukan wawancara kepada informan yang terkait dengan penelitian. Hasil penelitian menunjukkan bahwa remaja menggunakan media sosial Facebook untuk mendapatkan sumber informasi berdasarkan fakta. Di sisi lain, Facebook dijadikan sebagai platform sharing pengalaman ataupun hobi bagi remaja. Fitur-fitur yang canggih dalam Facebook seperti fitur marketplace, permainan, dan lain-lain menjadi daya tarik untuk tetap menggunakan Facebook. Selain itu juga Facebook dianggap remaja sebagai platform hiburan yang dapat menghilangkan jenuh di waktu luang.
Development of leadership qualities of masters in Germany
Authors: Sapohov Mykyta , Hapchuk Yana , Salii Roman
Published: May 2024

The evolution of leadership attributes emerges as a pivotal facet for contemporary professionals, delineating a trajectory towards triumph in career pathways and exerting influence within their milieu. Master's programmes within the German educational milieu meticulously integrate these imperatives, furnishing a refined platform for the cultivation of leadership acumen adeptly attuned to contemporary exigencies. Germany, renowned for its educational eminence, stands as a vanguard in the realm of nurturing and honing the leadership proficiencies of master's students. This discourse elucidates the elemental constituents underpinning master's programs in leadership, encompassing theoretical underpinnings, personal metamorphosis, pragmatic managerial competencies, and the intricacies of intercultural discourse. The emphasis is laid on the transformative potential of such initiatives in crafting well-rounded leaders primed to tackle multifarious challenges across divergent spheres of existence, thereby catalysing societal advancement. German tertiary institutions offer an extensive array of programmes designed to furnish students with a comprehensive understanding of leadership theory, foster personal development, inculcate pragmatic management skills, and facilitate adept navigation of intercultural dynamics. These programmes are instrumental in endowing students with the requisite knowledge and proficiencies to emerge as adept leaders across diverse domains encompassing business, politics, civil society, academia, and research. They serve as conduits for the cultivation of strategic cogitation, judicious decision-making, proficient communication, and adept team leadership. Furthermore, they serve to fortify the fabric of leadership by engendering qualities such as accountability, ethical rectitude, adaptability, and cross-cultural fluency. Moreover, they serve to galvanise independence, foster ingenuity in problem-solving, and impart skills in strategic foresight and planning, essential facets of efficacious leadership.
The peculiarities of organizing pedagogical courses in Podillia in the first quarter of the twentieth century
Authors: Zuziak Tetiana , Melnychuk Oleh , Vovkovynskyi Oleksandr
Published: May 2024

Based on archival and literary sources, the article examines the history of the creation of Vinnytsia short-term pedagogical courses for school, preschool and out-of-school education workers, Higher permanent 3-year pedagogical courses (Vinnytsia, Tulchyn, Bershad, Olgopil, Haysyn, Tyvriv, Khmilnyk, Nemyriv, Zholoby, etc.), which were established to provide teachers for all types of schools in Podillia in the first quarter of the twentieth century. The changes and innovations in the educational process of pedagogical courses have been considered, the peculiarities of the professional training of future teachers in the history of the formation of the national pedagogical system have been highlighted. It has been proven that pedagogical courses were almost the only pedagogical training that provided the retraining of teachers in the conditions of the transition period of pedagogical education, and as a result - the actual lack of professional training of future teachers, which negatively affected the entire educational system of Podillia, where graduates of pedagogical courses were working. It has been proven that pedagogical education has undergone numerous reforms and will continue to require in-depth study in the first quarter of the twentieth century in Podillia. Pedagogical courses were intended to improve the professional training of future teachers, to upgrade their future activities - to systematize purely pedagogical training, to acquaint them with the basics of didactics and methodology, with the best methods and techniques of teaching. It has been proven that, during the researched period of practice, the courses were assigned the same tasks that were to be performed by the pedagogical educational institutions, however, they could not replace the training of teachers in special pedagogical educational institutions.
Scientific and pedagogical preconditions for the development of the problem of formation of research competence of masters in educational sciences
Authors: Melnyk Alla
Published: May 2024

University education as a historical and cultural phenomenon has its own history, traditions, transformative and renewing potential. It realizes its mission and performs functions that turn it into a special value, in particular, it exerts a cultural and ideological influence on public consciousness; acts as a mechanism for the selection and socialization of the ruling elites; provides new knowledge and carries out scientific research; prepares qualified specialists; transfers cultural capital. The article reveals the content and significance of research activities based on higher education institutions in a retrospective aspect, the content of the concept and the main requirements for the educational and qualification level of a master's degree as a scientific degree.
The preconditions for the emergence and the development of the idea of ​​the formation of scientific and research competence of students at domestic universities have been considered. The problem of applying the research approach as a basis for training specialists in higher education has been studied. It has been established that the research approach in education is a set of pedagogical goals aimed at developing students' readiness for research work through its implementation in the educational process. Research work is defined as a special type of intellectual and creative activity of students, which arises as a result of the functioning of individual mechanisms of search activity and involves independent research aimed at theoretical and experimental study of phenomena and processes, substantiation of facts, identification of regularities using methods of scientific knowledge.
Spokes of Regime Change in Israel
Authors: Haklai Oded
Published: May 2024

The proposal introduced in January 2023 for a ‘judicial overhaul’ in Israel has been characterized as a seismic event. Labeled a ‘reform’ by supporters and a ‘coup’ by skeptics, the proposal is better understood as part of a long process rather than a sudden event. This process involves gradual but persistent executive aggrandizement advanced by weakening multiple institutions of horizontal accountability and the media, alongside the imposition of restrictions on oppositional organizational capacity. Accordingly, the process should be defined in terms of autocratization. The spokes analogy is invoked to highlight the interconnectedness between the various realms that collectively underpin the regime.
The 2023 Judicial Reform That Wasn't
Authors: Segev Joshua
Published: May 2024

This article offers two interpretations of the constitutional confrontation that ensued over the proposed 2023 judicial overhaul legislation. It places the debate in the context of a broader culture war over Israel's conditions of legitimacy and as a continuum. At one end of the spectrum, the judicial overhaul legislation can be seen as pursuing a ‘decision to decide’ tactic, countered by the opposition using the same constitutional tactic in the opposite direction. On the other end of the spectrum, the judicial overhaul program could be viewed as an opening position in constitutional negotiations, with reform advocates seeking only the nomination of a few committed conservative justices and the maintenance of the constitutional status quo of deciding not decide. To this end, the nationalists’ move was again countered by the opposition using the same constitutional tactic but in the opposite direction to prevent this outcome.
Flowing with Reality (Musaiyyara)
Authors: Abed Salwa Alinat
Published: May 2024

This article delves into the intricate relationship between the Islamic Movement and the authorities in Israel. It specifically examines the strategy of integrating the southern faction into Israeli politics in recent years and during the emergence of the democracy crisis in Israel. I term this strategy ‘the politics of musaiyyara’ (flowing with reality), a distinctive approach within the Israeli context. This approach utilizes the Knesset as a platform for forging new alliances with Zionist actors, sidestepping discussions on issues related to the Israeli occupation. The article relies on primary sources that convey the perspectives of the Islamic Movement, specifically its two leaders, Sheikh ʻAbd Allāh Nimr Darwīsh, representing the old generation, and MK Mansour Abbas, representing the newer generation within the movement.
Sovereignty in Hebrew and the Decline of Democracy
Authors: Jones Meirav , Shitrit Lihi Ben
Published: May 2024

Since assuming office in December 2022, Israel's government has worked to weaken the state's democratic infrastructure. While this appears to break from a long-standing Israeli consensus on democracy, this article demonstrates that retiring democracy has long been the agenda of the faction of the Israeli right most empowered in Israel's current government, namely the settler movement. Following the discourse in Sovereignty: A Political Journal, it finds that by recasting ‘sovereignty’ as involving annexation and disenfranchizing Palestinians, the settler right has consistently portrayed democracy—and particularly the Supreme Court that serves as a check on governmental power and protects minorities—as an obstacle to ‘sovereignty.’ Considering the settler right's political vision, the article claims that defending democracy today will necessarily involve engaging contentious questions of occupation and annexation.
HISTOSTRUCTURAL ALTERATIONS IN THE CEREBRAL ARCHITECTURE ASSOCIATED WITH THE PROGRESSION OF ALCOHOL INTOXICATION: AN EXPERIMENTAL ANALYSIS
Authors: Nazarova D.I. , Kramar S.B. , Kozhushko G.Y. , Kozhushko V.V. , Barbashova Y.P.
Published: May 2024

The aim of this study is to evaluate the histological changes in the cerebellum of rat brains following chronic alcohol intoxication. Materials and Methods. We employed a classical approach for modeling chronic alcohol intoxication by administering 40% ethanol to rats (n=55) in a dosage of 2 ml per 100 g of body weight daily for three months. The cerebellar structure was then analyzed. Results. This study investigates the impact of chronic alcohol intoxication on the histological structures of the cerebellar cortex. The cerebellum, like the nervous system overall, possesses a significant cellular and functional reserve. However, teratogenic factors, including ethanol, notably influence the activity of cerebellar neurons, increasing it. Ethanol exposure during early pregnancy can lead to prenatal growth retardation, stillbirth, cleft palate, hydrocephaly, and reductions in fetal body size. There is evidence suggesting a correlation between blood ethanol levels and a reduction in the number of Purkinje cells. Chronic alcohol consumption results in cerebellar ataxia, alterations in upper limb movements, decreased reaction speeds, reduced attention concentration, impaired coordination accuracy, and disturbances in postural stability and balance. Conclusion. The cerebellum, especially during development, is particularly vulnerable to the toxic effects of alcohol. Recent research suggests that changes in the neurotransmission of gamma-aminobutyric acid (GABA)-dependent receptors may contribute to cerebellar dysfunction induced by ethanol. Ethanol exposure increases the release of GABA not only in Purkinje cells but also in the interneurons of the molecular layer and granule cells.
NOSOLOGICAL STRUCTURE OF IN-PATIENT PSYCHIATRIC CARE PROVISION IN THE POLTAVA REGION IN 2023
Authors: Kydon P.V.
Published: May 2024

Introduction. The importance of safeguarding mental health and providing high-quality psychiatric care became increasingly urgent following the onset of full-scale war in Ukraine. Currently, a strategy to transfer psychiatric care from specialized institutions to primary care is being implemented. Therefore, analyzing the nosological distribution of referrals to a psychiatric hospital during martial law is an extremely urgent issue. The aim of this study is to investigate the nosological structure of hospitalizations at the Communal Enterprise “Regional Institution of Mental Psychiatric Care of the Poltava Regional Council” in 2023.
Results and their discussion. Schizophrenia remains the leading diagnosis among patients receiving inpatient psychiatric care. The second place is taken by neurotic, stress-related, and somatoform disorders. In third place are organic, including symptomatic, mental disorders, with vascular dementia being the leading primary diagnosis among patients with organic, including symptomatic, mental disorders. Among the substances causing mental and behavioral disorders due to the use of psychoactive substances, alcohol ranks first. Paranoid schizophrenia is the leading diagnosis in patients with schizophrenia, schizotypal states, and delusional disorders. Recurrent depressive disorder is the most common among affective disorders. Adjustment disorders occupy the first place in the structure of the incidence of neurotic, stress-related, and somatoform disorders. Among the behavioral syndromes associated with physiological disturbances and physical factors, anorexia nervosa is the most common. Emotionally unstable personality disorder is most common among patients with disorders of adult personality and behavior. Mild mental retardation is more common than others. Childhood autism has the largest share in the incidence structure of disorders of psychological development. Among behavioral and emotional disorders with onset usually occurring in childhood and adolescence, the most common are mixed disorders of conduct and emotions.
Conclusion. The obtained results can be used in planning and forecasting the provision of inpatient psychiatric care to patients during the wartime.
HEALTHY LIFESTYLE INDICATORS AMING MEDICAL STUDENTS AT POLTAVA STATE MEDICAL UNIVERSITY
Authors: Tymoshenko V.M. , Syngaivskyi A.M. , Morokhovets H.Y. , Pushko O.O.
Published: May 2024

The aim of the research is to study the indicators of a healthy lifestyle among Master students at Poltava State Medical University, and factors influencing this choice.
The article analyzes the results of a survey among 228 students of the 1st-3rd years of study at Poltava State Medical University. We used the Google Forms service (https://docs.google.com/forms) to conduct the survey. The questionnaire was distributed through student groups in Viber and Telegram social networks.
Results. In this study, 94.7% of students agreed to participate. Male students made up 29.6% of participants, female participants constituted 70.4%. The average value of BMI was 22.34 (CI [20.16-24.35]) in men and 21.07 (CI [19.23-22.29]) (p=0.019) in women.
A statistically significant difference was observed between the BMI values of students who lived in a dormitory, the average BMI was 20.82 (CI [19.26-21.76]), compared to those who lived with their families in their own housing, where BMI was 21.54 (CI [19.46-22.82]), and those in rented housing, where BMI was 21.87 (CI [19.22-23.74]) (p<0.0001).
The mean score for tendency to crash diet for weight loss in the male group was 0.15 (CI [0-1.0]), compared to the female group, where it was 0.41 (CI [0-1.0]) (p=0.0104).
The mean score for the frequency of walking in the group aged 16-18 was 2.25 (CI [1.0-3.0]), 19-21 - 2.33 (CI [1.0-3.0]), 22-24 - 1.33 (CI [1.0-2.0]), >24 - 2.0 (CI [1.0-2.0]) (p=0.00805).
The mean score for the frequency of walking in the group of students living in rented housing was 2.18 (CI [1.0-3.0]), in the group living in a dormitory - 2.47 (CI [1.0-3.0]), in the group living with family - 2.07 (CI [1.0-2.0]) (p=0.0014).
Conclusion. A healthy diet, sleep, and exercise must be balanced to improve mental and physical health, and thus to improve the performance of medical students.
In general, students should be instructed to maintain proper sleep hygiene, recommended reducing the time spent using the devices, especially in the evening, avoiding alcoholic beverages, as well as setting various reminders and alarms.
THE ISSUE OF INFECTIOUS DISEASE INCIDENCE AMONG MEDICAL STUDENTS
Authors: Shevchuk T. I.
Published: May 2024

Introduction. The training of future medical professionals involves not only development of skills and professional background, but also maintaining a sufficient health status; therefore the relevance of studying an incidence of infectious pathologies in medical students is exceptionally important. The purpose of the study is to investigate, analyze, and compare incidence of some infectious diseases among medicine students. Materials and methods. We utilized various research methods including analysis of scientific sources, synthesis and comparison of studies by other researchers, surveys, observations, interviews, and statistical data on the incidence of infectious diseases in Ukraine and worldwide. Additionally, we conducted a poll among first-year students of the medical faculty at Vinnytsia National Pirogov Memorial Medical University using Google Forms to gather data on the incidence of respiratory and digestive system infections.
The study revealed that approximately 65% of the surveyed students had experienced coronavirus disease, mostly in a mild form. Among acute respiratory viral infections, flu (55.3%), sore throat (31.3%), and rhinopharyngitis (21.3%) were the most common (79.1%) among medical students. About 74% of respondents reported no chronic diseases of the upper and lower respiratory tract, while the rest mentioned conditions such as allergic rhinitis (10%), chronic tonsillitis (10%), chronic pharyngitis (3.4%), and vocal cord diseases (2%). In terms of infectious pathologies of the digestive system, food poisoning of unspecified etiology (33.3%) and viral intestinal infections (11.7%) were the most prevalent.
Conclusion. The relevance of the issue of infectious disease incidence among medical students necessitates further investigation and analysis to identify contributing factors, develop monitoring methods, and promote healthy lifestyles to maintain optimal health status.
ANALYZING DEVICES AND METHODS FOR ASSESSING THE PRIMARY STABILITY OF ORTHODONTIC MINI-IMPLANTS
Authors: Shaienko D. P.
Published: May 2024

When disruptions occur in the mechanisms regulating the eruption of lower jaw molars, it becomes necessary to artificially extract and reposition them within the dentition. Various treatment methods are employed for this purpose, with the primary approach involving traction fixed to teeth or other anchorage elements and bone supports. Skeletal support is preferred to minimize resistance from orthodontic appliances when applying force to the patient's teeth.
The utilization of mini-implants for anchorage demonstrates a relatively high success rate, though instances of failures and complications are not unheard of. Potential issues such as stability loss and mini-implant displacement may necessitate relocation or adjustments to treatment strategies, posing challenges for both practitioners and patients.
Unlike dental implants, where secondary stability often dictates treatment success, primary stability holds paramount importance for orthodontic mini-implants. Investigating primary stability parameters can significantly impact treatment strategy selection and orthodontic mini-implant loading timelines.
Focusing solely on mini-implant torque during placement is inadequate, as it fails to comprehensively gauge real stability. Moreover, the available range of torque indicators for orthodontic mini-implant placement is limited, typically ranging from 5ncm to 10 ncm. Furthermore, the selection of specialized devices for measuring primary stability is limited and necessitates meticulous evaluation.
FOSTERING KEY VALUES OF ACADEMIC INTEGRITY THROUGH THE EDUCATIONAL PROCESS AT POLTAVA STATE MEDICAL UNIVERSITY
Authors: Petrushanko T.O. , Boychenko O.M. , Bublii T.D.
Published: May 2024

Academic integrity serves as the cornerstone of an individual's moral character and their approach to scholarly endeavors. It reflects the moral values that students bring with them to higher education institutions, aiming to enhance and refine them throughout their academic journey and beyond. This article aims to explore the principles underlying the development of academic integrity among teachers, lecturers, and its implementation in the scholarly and educational activities of higher education institutions. Lecturers serve as the primary examples of academic integrity for students. Their commitment to ethical standards, honesty, and openness in discussing ethical issues can influence students and serve as a model for their behavior. At Poltava State Medical University (PSMU), a repository has been established as a platform for showcasing teachers' scientific achievements, publications, research, and other academic accomplishments. Additionally, a bioethics commission oversees adherence to data collection and processing rules, animal experimentation, and the use of new technologies, fostering a conducive atmosphere in line with the ethical standards of academic integrity at PSMU. The patent department at PSMU oversees research ethics, citation rules, and plagiarism prevention, providing educational support, consultation, and assistance in developing intellectual property standards. The university's website offers online resources that encourage teachers to take greater responsibility for their actions and achievements. By making achievements publicly accessible, PSMU promotes adherence to ethical and quality standards among faculty members. Thus, fostering a virtuous academic environment requires a comprehensive approach that includes proper regulatory and legal frameworks, as well as organizational and preventive-educational measures. Establishing an educational environment based on academic integrity for future professionals enables high-quality outcomes, thereby shaping competitive specialists in the global market of social services.
INDICATORS OF CENTRAL HEMODYNAMICS IN ACQUIRED MYOPIA
Authors: Ivasenko А.Yu. , Sheiko V.І.
Published: May 2024

Introduction. The presented study focuses on investigating the impact of acquired myopia on human central hemodynamics. Myopia, or nearsightedness, ranks as one of the most common ophthalmological disorders globally and in Ukraine, manifesting either congenitally or acquired over a lifetime. Ophthalmology specialists note a rapid increase in myopia cases across all age groups, with its prevalence posing a significant threat to vision and overall health. Viewing myopia as an adaptive response to a substantial visual strain one can presume that this adaptation might not be localized but generalized.
The objective of the study is to examine the characteristics of central hemodynamics in individuals with acquired myopia.
Materials and methods. The research was conducted on volunteers, 81 individuals aged 18 – 35, who were divided into a control group of 40 persons and a study group of 41 individuals diagnosed as having myopia. The diagnosis was established by specialists in Dnipro. The study was carried out at the General Practice Family Medicine Clinic No. 7 in Dnipro during 2022-2023. Central hemodynamic status was characterized by the following indicators: heart rate, systolic and diastolic blood pressure, pulse pressure, systolic blood volume, and minute blood volume. The Kerdo’s vegetative index was also calculated.
 Results. The study revealed that acquired myopia was accompanied by an increase in the absolute values of heart rate, systolic blood pressure, diastolic blood pressure, pulse pressure, and minute blood volume compared to the control group of volunteers. It is noteworthy that the systolic blood volume in the context of acquired myopia was lower than in the control group. The Kerdo’s index was higher in the group with acquired myopia compared to the control group. The obtained results indicate a certain dependency between central hemodynamics indicators, the Kerdo’s index value, and acquired myopia, which is an adaptive reaction of the visual system to significant loads in the modern information-cybernetic society. Changes in central hemodynamics indicators in individuals with myopia may reflect certain adaptive reactions of the cardiovascular system to this eye refraction disorder.
PHARMACOLOGICAL EFFECTS OF MELATONIN AND ITS POTENTIAL APPLICATION IN THERAPY OF GOUT AND ASSOCIATED DISEASES
Authors: Berzin O.V. , Kondratiuk V.E.
Published: May 2024

Introduction. The disturbance in biosynthetic activity of pinealocytes of the pineal gland and subsequent melatonin deficiency in the body are linked to the progression of certain chronic diseases. This has prompted research into correcting chrono-biological dysfunctions, particularly in conditions such as gout and its comorbidities. This study aims to analyze the potential use of melatonin in correcting metabolic disorders in gout and to justify its use as a pharmacotherapeutic agent for treating metabolic and cardiovascular diseases.
Materials and methods. We conducted a comprehensive analysis of modern scientific literature from specialized domestic and foreign sources. Emphasis was placed on studies exploring the pharmacological and pharmacotherapeutic aspects of melatonin use in both experimental and clinical settings, particularly those conducted in the last 5-6 years.
Results. The research data revealed three main aspects of the problem that must be addressed to understand the experimental, biological, pharmacological, and pharmacotherapeutic foundations for the long-term use of melatonin in clinical practice. The first part of the review highlighted the significant impact of melatonin homeostasis disruption on the pathogenesis of gout and its progression in comorbidity with other conditions such as hypertension, obesity, insulin resistance, metabolic syndrome, and type 2 diabetes. The role of chronobiological disorders and desynchronosis in the progression of these diseases was also established. Pharmacological studies demonstrated the pivotal role of melatonin, as an important factor in neuroendocrine regulation, in organizing the circadian rhythm of the body's vital functions under normal and pathological conditions. Melatonin was found to normalize the pathological processes underlying gout development and comorbid diseases, providing a scientific basis for its use in the treatment of gout, cardiovascular diseases, disturbed metabolic processes, and normalization of circadian rhythms in patients with these conditions.
Conclusions. This paper presents data on the causes of gout development and progression, as well as some comorbid diseases, from the perspective of chronobiological disruptions in the body's functions. The review sections delve into the pharmacological and pharmacotherapeutic aspects of melatonin's therapeutic action. The findings confirm the importance of melatonin in effectively treating gout and other comorbid diseases and metabolic disorders.
A CLINICAL REVIEW OF DIAGNOSTIC BIOMARKERS AND THE ROLE OF THE GUT MICROBIOTA IN PRETERM INFANTS WITH NECROTIZING ENTEROCOLITIS
Authors: Musayev A.A.
Published: May 2024

The purpose of this work is to clarify the latest opinions of clinicians about the pathogenesis, diagnosis and treatment of necrotic enterocolitis, as well as the role of microflora in the pathogenesis of this pathology. Material and methods. Search Strategy: A literature search was conducted in the following electronic databases: PubMed, Web of Science (Thomson Reuters), Scopus, Cochrane Library, SpringerLink, and EBSCOhost ScienceDirect. The search spanned 20 years, from 2000 to 2020. In this review, we included 39 articles on this topic, which were available in full text and analyzed through critical evaluation. Results.According to the literature, necrotizing enterocolitis is primarily attributed to prematurity, compounded by the disruption of intestinal microflora composition due to artificial feeding, leading to an inflammatory reaction in the immature intestine. Delayed detection of the initial signs of necrotizing enterocolitis exacerbates treatment outcomes. In clinical practice, two main dilemmas in necrotizing enterocolitis diagnosis arise. Firstly, distinguishing early necrotizing enterocolitis from sepsis can be challenging, resulting in delayed diagnosis and treatment. Secondly, the optimal timing for surgical intervention remains unclear. Conclusion. There is a need to elucidate the latest opinions of clinicians regarding the pathogenesis, diagnosis, and treatment of necrotizing enterocolitis, including the role of microflora in its pathogenesis. Treatment strategies should integrate various models of clinical prognosis and biomarkers to accurately diagnose and tailor therapy for necrotizing enterocolitis.
STUDY OF ANTIBIOTIC RESISTANCE AT REGIONAL LEVEL
Authors: Lutsenko O.A. , Ostrovska G.Yu. , Lavrenyuk Yu.M. , Petrova T.A. , Lutsenko R.V.
Published: May 2024

The introduction of antibiotics revolutionized medicine, dramatically reducing deaths and illnesses caused by infections. However, decades of overuse have accelerated the evolution of microorganisms, leading to a critical challenge: antibiotic resistance. This research aims to investigate the regional risk factors contributing to antibiotic resistance among the Poltava region population.
Materials and methods. 100 patients of the 2nd Municipal Clinical Hospital and the Regional (Republican) Center for Emergency Medical Aid and Disaster Medicine of Poltava were included in the study. Data collection was carried out from November 2023 to March 2024. Patients were offered a series of 11 questions.
Research results. This study has revealed the following antibiotic usage patterns among the residents of the Poltava region. It has been found that 22% of respondents are currently undergoing treatment, 8% in the last month, 36% in the last year, and 34% of the respondents tool the treatment for more than a year. When using antibiotics without a prescription, 30% of patients consulted a pharmacy, 52% trusted the Internet, 10% chose the cheapest medicine, and 8% followed advertisements. For subsequent illnesses, 76% of respondents used antibiotics they had taken before: amoxicillin (42%), ciprofloxacin (28%), azithromycin (22%), and chloramphenicol (8%). While 80% reported following prescribed antibiotic regimens, 20% interrupted treatment prematurely due to perceived improvement. Despite 84% acknowledging the importance of completing antibiotic courses, a concerning 16% were unaware of this crucial practice. Interestingly, 11% reported using antibiotics for preventive purposes (before getting sick). However, a positive trend emerged: 85% of respondents confirmed undergoing testing for bacterial susceptibility before receiving antibiotics. Only 9% reported amoxicillin as ineffective. When antibiotics were ineffective, 46% of respondents consulted a doctor, 24% took no action and waited for the antibiotic to take effect, 21% stopped one antibiotic and started another, and 14% preferred intramuscular injections and self-medication.
Conclusion. A significant number of patients (48%) take antibacterial drugs without a doctor's prescription and 52% search for information on the Internet. 76% of patients use the same drug for a recurrent disease. Amoxicillin is the most often preferred (42%), a smaller number of patients came to the pharmacy for ciprofloxacin (28%), 22% of respondents preferred azithromycin. This study underscores the necessity for public health interventions to tackle antibiotic misuse and misconceptions in the Poltava region. Promoting responsible usage, emphasizing the importance of completing treatment courses, and discouraging self-medication are crucial steps in combating the growing threat of antibiotic resistance.
IMPACT OF CORONARY ARTERY DISEASE ON STEATOTIC LIVER DISEASE PROGRESSION
Authors: Pilat I.O. , Skrypnyk I.M.
Published: May 2024

Introduction. Metabolic dysfunction-associated steatotic liver disease and coronary artery disease often exacerbate each other, leading to a more severe course of both conditions.
The aim of this study is to evaluate the role of coronary artery disease in dislipidemia and liver fibrosis progression in patients with metabolic dysfunction-associated steatotic liver disease.
Materials and methods. Forty-six patients with metabolic dysfunction-associated steatotic liver disease were examined. Patients were divided into two groups based on the presence of concomitant coronary artery disease: group I (n=24) included patients with both metabolic dysfunction-associated steatotic liver disease and coronary artery disease, while group II (n=22) included patients with metabolic dysfunction-associated steatotic liver disease only. A third group (Group III) comprised healthy individuals. Specific lipid metabolism parameters, obesity stage, alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (GGT) activity, and platelet count were examined. Fibrosis stage was evaluated using the FIB-4 score. The findings obtained were statistically processed.
Results. Arterial hypertension was more prevalent in patients with metabolic dysfunction-associated steatotic liver disease and concomitant coronary artery disease. In group I, arterial hypertension was observed in 95.8% of cases, whereas in group II, it was observed in 40.9% of cases (χ2=16.35, p=0.00005). Patients with metabolic dysfunction-associated steatotic liver disease exhibited elevated levels of total cholesterol, low-density lipoproteins, and triglycerides, leading to an increased atherogenic index. Conversely, high-density lipoprotein levels were decreased (p>0.05). The degree of fibrosis according to the FIB-4 score was 1.45 times higher in patients with metabolic dysfunction-associated steatotic liver disease and concomitant coronary artery disease compared to those without coronary artery disease.
Estrategias diagnósticas y terapéuticas en el tromboembolismo pulmonar de la gestante. Una revisión sistemática
Authors: Hidalgo Acosta Javier , Vázquez Cárdenas Andrés , Granja Lainez Denis , Cortez Salvatierra Karen , Rivera Gavilánez Nora , Malla Vijay Carlos , Pozo Gómez Cesar , Villamar Flores Genesis , González Sánchez Maryoli
Published: May 2024

Introducción: El tromboembolismo pulmonar (TEP) en la gestante, es una enfermedad grave provocada por  la obstrucción de la arteria pulmonar, que puede estar asociada con fallo del ventrículo derecho y alteración de la ventilación perfusión, cuya causa más común es un émbolo proveniente de trombosis venosa profunda, que pone en gran riesgo el bienestar materno fetal, motivo por lo que, se justifica esta investigación. Objetivos: El objetivo de la presente revisión es proporcionar las estrategias actualizadas para el manejo de la embolia pulmonar durante la gestación y el puerperio. Metodología: Los 37 artículos elegidos según los criterios de inclusión y exclusión que abordaron la pregunta de investigación fueron incluidos en la síntesis para su análisis. Se revisaron bases de datos como Pubmed, Mendeley, ScientDirect, Scielo y páginas web de revistas consultadas con última fecha de búsqueda el 17 de abril del 2024. Resultados: El manejo de la embolia pulmonar inestable debe realizarse mediante el uso del algoritmo YEARS con dímero D adaptado al embarazo, no se recomienda el uso de anticoagulantes orales durante el embarazo y la lactancia, cuandose trata de una embarazada con inestabilidad hemodinámica complicada por embolia pulmonar, se debe considerar la trombólisis o embolectomía. La trombólisis sistémica, está indicada en TEP masivo inestable, pero se debe tomar en consideración que, el embarazo es una contraindicación relativa de trombólisis, y el postquirúrgico de cesárea, es una contraindicación absoluta de trombólisis. Discusión: La evaluación inicial del episodio de embolia pulmonar, requiere un reconocimiento precoz, de acuerdo con las características clínicas y la gravedad, empleando las estrategias terapéuticas de anticoagulación, trombólisis, embolectomía y ECMO, así como también el uso de los filtros de vena cava inferior para la trombosis femoral recurrente o cuando existe alguna contraindicación para recibir anticoagulantes para obtención de mejores resultados.
АНАЛІЗ ПРОЦЕСУ РОЗПОВСЮДЖЕННЯ УЛЬТРАЗВУКОВИХ ХВИЛЬ В ПОЛІМЕРНОМУ ПОКРИТТІ НА МЕТАЛЕВІЙ ПЛАСТИНЦІ
Authors: ЗДОРЕНКО Валерій , МАТЯШ Олександр
Published: May 2024

В роботі проаналізовано та отримано залежності для модулів комплексних коефіцієнтів проходження та відбиття ультразвукових хвиль від двошарового матеріалу – полімерного покриття на металевій пластинці. Розглянуто можливість застосування ультразвукових хвиль для визначення товщини полімерного покриття на металевій пластинці малої товщини. Застосування інформативних параметрів хвиль для контролю товщини полімерного покриття дозволить оперативно визначати зазначений параметр в процесі нанесення плівки на металеву пластинку. Це дозволить вдосконалити технологічний процес нанесення полімерного покриття на металеву основу.
Hubungan Faktor Risiko dengan Kejadian Malaria di Kampung Nolokla Kabupaten Jayapura
Authors: Ayomi Ivon , Suyono Ign. Joko , Runtuboi Dirk Y.P.
Published: May 2024

Malaria is a dangerous disease and is still a public health problem in Indonesia, caused by parasites of the genus Plasmodium and transmitted by female mosquitoes of the genus Anopheles. The purpose of this study was to analyze the risk factors for the incidence of malaria and measured the magnitude of the various risk factors that influenced the incidence of malaria in Nolokla Village, East Sentani District, Jayapura Regency. This study used a case control study to find out how far the risk factors included the physical environment, the biological environment and the socio-cultural environment on the incidence of malaria. The case group was all people who declared clinical malaria while the control group was those who were declared free of malaria. The number of samples in this study were 60 respondents, the case samples were taken randomly as many as 30 people and the control group was also 30 people were taken by matching method. The results of the bivariate analysis showed that there were four risk factors, namely the breeding site, the condition of the walls of the house, the presence of shrubs and the presence of Anopheles larvae, and there were six risk factors that had no effect on the incidence of malaria so they were not included in the follow-up test. From the multivariate analysis, it was found that the risk factors that influenced the incidence of malaria were breeding site (p=0.035, OR=3.143, 95%CI 1.066-9.267), condition of house walls (p=0.028, OR=4.500, 95%CI=1.094-18,503), presence of shrubs (p=0.006, OR=5,000, 95%CI=1,510–16,560), presence of Anopheles larvae (p 0.028, OR=3,500, 95%CI=1.112-11.017). The most dominant risk factor that may play a role in the incidence of malaria was the presence of shrubs (Exp=3.095).   
Key words: malaria incidence; API; case control; Nolokla village.
Identifikasi Bahan dan Pembuatan Noken Tas Tradisional Serat Kayu Pada Masyarakat Lokal Kampung Rhepang Muaif, Distrik Nimbokrang Kabupaten Jayapura
Authors: Keiluhu Henderina J. , Chrystomo Linus Y. , Yuliana Sarah , Silitonga Ronauli
Published: May 2024

Local people in Rhepang Muaif Village, Nimbokrang District, Jayapura Regency usually use forest tree bark of three species, especially Dakwab wood, as raw material for noken, Papuan traditional woven bags. This study aimed to 1) scientifically identify the species of trees used for noken, 2) describe how to process fiber as a raw material, and 3) reveal the source of natural dyes used. Data collection was carried out using survey method, semi-structured interviews and participant observation. The result shows that in Rhepang Muaif, some species are used as raw material for noken, mainly species of Dakwab tree (Grewia paniculata). Dakwab fibers are generally coloured with natural dyes derived from Merei plant (Bixa orellana) for red colour and turmeric (Curcuma domestica) for yellow colour. The process of utilizing Dakwab bark as a noken fiber material starts from debarking the tree, stripping the bark, then washing, drying, and making the fiber from tree bark, later colouring if necessary and finally woving or knitting the fiber to become the bag.
Studi Etnomatematika tentang Bagas Godang sebagai Unsur Budaya Mandailing di Sumatera Utara
Authors: Dewita Azhari , Mujib Abdul , Siregar Hasratuddin
Published: May 2024

Tujuan penelitian ini untuk mengetahui konsep (ide-ide) matematika yang terdapat  pada rumah adat Mandailing  yaitu Bagas Godang. Mandailing adalah salah satu suku Batak yang terletak di Kabupaten Tapanuli Selatan Sumatera Utara. Salah satu unsur budaya Mandailing adalah rumah adat Bagas Godang Sumatera Utara yang seharusnya menjadi perhatian pemerintah daerah setempat. Bagas Godang merupakan unsur budaya Mandailing yang dapat di jadikan media pembelajaran matematika sekolah, sehingga pembelajaran matematika dapat dimulai dari memperkenalkan budaya lokal seperti rumah adat budaya Mandailing atau Bagas Godang. Tulisan ini mengeksplorasi konsep-konsep matematika pada struktur dan ornamen rumah adat Bagas Godang. Pembahasan yang bersifat deskriptif memberi gambaran tentang ornamen rumah adat Bagas Godang lebih terperinci. Hasil eksplorasi dan analisis ornamen-ornamen Bagas Godang ditemukan adanya konsep matematika berupa konsep grup, geometri dan trasformasi geometri dan komposisinya.
Pengaruh Penggunaan Lembar Aktivitas Siswa Berbasis Metode Penemuan Terbimbing terhadap Peningkatan Kemampuan Representasi Matematis Siswa
Authors: Annajmi  , Afri Lusi Eka
Published: May 2024

Penelitian ini bertujuan untuk mengetahui ada atau tidaknya pengaruh penggunaan Lembar Aktivitas Siswa (LAS) berbasis metode penemuan terbimbing terhadap kemampuan representasi matematis siswa SMP. Penelitian ini merupakan penelitian quasi eksperimen dengan Pretest Posttest Control Group Design. Penelitian ini dilakukan di SMPN 3 Rambah pada siswa kelas VII. Data yang dikumpulkan adalah data peningkatan kemampuan representasi matematis siswa. Instrumen yang digunakan adalah soal essay yang disusun berdasarkan indikator kemampuan representasi matematis. Hasil analisis data menggunakan uji Mann Whitney diperoleh nilai Zhitung yaitu 2,13 dan nilai Ztabel yaitu 1,96. Hal ini berarti Zhitung > Ztabel dengan demikian sesuai kriteria penguhian hipotesis, Ho ditolak. Oleh karena itu dapat disimpulkan bahwa ada pengaruh yang signifikan penggunaan LAS berbasis metode penemuan terbimbing terhadap peningkatan kemampuan representasi matematis siswa SMP.