bluuebunny/crossref_metadata_2025 huggingface dataset:
INTERVENCIÓN CON DOS PROGRAMAS DE ENTRENAMIENTO SOBRE LA COORDINACIÓN Y LOS CAMBIOS DE DIRECCIÓN EN JUGADORES JÓVENES DE FÚTBOL SUB-14
Authors: Pérez S. , Sánchez A. , De Mena J.M. , Alonso G. , Rodríguez A.
Published: January 2023

El objetivo del estudio fue analizar el efecto de dos programas de entrenamiento sobre la coordinación y los cambios de dirección en jugadores jóvenes de fútbol sub-14 con diferentes metodologías, tradicional y alternativa, y en función del puesto de juego. Se analizaron a 34 jugadores, divididos en dos grupos de intervención uno tradicional y otro alternativo. Ambos grupos realizaron ocho sesiones de entrenamiento. Las variables analizadas fueron la coordinación motriz a través del test SPORTCOMP y los cambios de dirección con el test MAT-T con y sin balón. Los principales resultados mostraron que el grupo tradicional mejoró en todas las variables analizadas de forma significativa (p<0,05) y con tamaño del efecto entre mediano y grande. El grupo alternativo mejoró en cinco variables de forma significativa, sin embargo, no mejoraron de forma significativa en dos de ellas (p<0,05). Por lo tanto, el programa de entrenamiento tradicional, a través de la asignación de tareas motrices, incrementaron las mejoras en la coordinación y en los cambios de dirección, en mayor medida que el programa alternativo de entrenamiento, tanto de forma significativa como en el tamaño del efecto que provocaron.
ANÁLISIS DEL PERFIL FISIOLÓGICO, METABÓLICO Y ESTRUCTURAL DEL TENIS DE MESA DESDE UNA PERSPECTIVA DE GÉNERO
Authors: De la Torre A. , González-Jurado J.A. , Vicente-Rodríguez G. , Castellar C. , Pradas F.
Published: January 2023

En las últimas dos décadas el tenis de mesa ha experimentado importantes transformaciones en su reglamento y en los materiales de juego. Estas modificaciones han supuesto una evolución hacia un tenis de mesa más moderno y dinámico. Diversas investigaciones describen el esfuerzo y la dinámica de juego del tenis de mesa masculino. Sin embargo, existe un gran desconocimiento de la estructura de juego y del impacto que supone la práctica de este deporte en las mujeres. El objetivo de este estudio ha sido analizar la respuesta fisiológica y metabólica y la estructura de juego del tenis de mesa actual considerando a ambos géneros. Una muestra de 48 jugadores de elite (24 jugadores y 24 jugadoras), participaron en una competición simulada para evaluar la respuesta cardiaca, los niveles de lactato y diferentes parámetros estructurales de juego. Se han encontrado diferencias entre el juego masculino y femenino en los registros cardíacos mínimos (p<0,004) y máximos (p<0,001), en los niveles de lactato (p<0,001), en los tiempos de juego (p<0,01) y en el número de golpeos efectuado por jugada (p<0,01). El tenis de mesa se caracteriza en ambos géneros por la realización de esfuerzos submáximos, una gran variabilidad cardiaca y un metabolismo de predominio anaeróbico aláctico. El juego desarrollado en la competición masculina es más rápido y explosivo que el de la femenina caracterizado por efectuarse un mayor número de golpeos por jugada. Se hace necesario la realización de nuevos estudios en donde se considere el estilo de juego y los materiales de juego utilizado por los deportistas analizados. Esta investigación resulta de gran interés y relevancia en la actualidad por ser pionera en el tenis de mesa femenino describiendo el esfuerzo y la dinámica de juego que lo caracteriza.
Assessment of the Level of Depression and Vulnerability of Settlements: on the Example of the Regions of Western Kazakhstan
Authors: Kireyeva A. A. , Nurlanova N. K. , Kenzhegulova G. K. , Kenzheali Y.
Published: January 2023

The aim of the study is to assess the level of vulnerability of the economy and social sphere of depressed settlements in the example of the regions of western Kazakhstan (Atyrau, Mangystau and West Kazakhstan). The following research methods were used to visualize the data: bibliographic, tabular, and grouping of data. The initial data for 2009-2020 for the study were taken from statistical data of the Bureau of National Statistics, regional departments of statistics, various electronic resources, etc. According to the results of the analysis, indicators of the development of districts in Mangystau, Atyrau and West Kazakhstan regions were obtained, in which depressed and vulnerable territories were identified. The data obtained indicate that in vulnerable areas of Kazakhstan there is significant interregional inequality in terms of the level and quality of life. A number of social indicators of the level and quality of life of the population have huge interregional gaps. The analysis as a whole makes it possible to positively assess the possibilities of the prospective development of these territories within the framework of the historically developed specialization of the economy in the presence of transport flows between cities and regions. At the same time, to outline ways to further diversify their economies in order to get out of the state of depression and vulnerability. The developed methodology was tested on the example of the regions of Western Kazakhstan, which proves the possibility of its application both by government authorities to identify settlements in need of state support and in further research.
Evaluating the Effectiveness of Health Care Systems: Foreign Experience
Authors: Satybaldin A. A. , Omir A. , Ruzanov R. M.
Published: January 2023

Purpose of the work to analyze the features of the formation and functioning of the healthcare model and to summarize the experience of applying various methods of managing healthcare systems in developed and developing countries. Research method: descriptive research methods, analogy methods, groupings, scientific factual, systematic, comparative and retrospective analysis are used as instrumental methodological methods for studying the problem, but general scientific research methods (derivation, deduction, collection and processing of statistical information). This provides a basis for comparing the development of public health management tools applied in foreign countries. Analyzing the directions of development of health care systems in developed and developing countries, we find that, depending on the existing health care system, the goals, objectives and mechanisms of development can be similar or differ greatly. The search for the best model, carried out in both developed and developing countries, makes it impossible to create a unified approach to building a health care system that will ensure the creation of the most effective health care system. The effectiveness of the functioning of health care systems and the achievement of the goals set to improve people's health are less related to the implementation of specific management activities but are related to the socio-economic conditions of management. Their implementation and the existing healthcare system. This is confirmed by the similar rates of increase in life expectancy at birth in developed countries, despite significant differences in management tools and a natural difference in management tools.
The Hypothesis of Stock Market Instruments: Modern Aspects, Forms and Anomalies
Authors: Kulanova D. A. , Sarsenbekova P. B. , Tashov E.
Published: January 2023

The relevance of the results of the presented research is also related to their demand both from investors and issuers and from research scientists. For research scientists, the predictability of profitability or the lack of such predictability is crucial for creating models that would be able to accurately describe risks and profitability in financial markets. The methods and techniques used in the study allow us to determine the general trend of the market movement toward increasing or decreasing its efficiency. For investors, such an assessment of the effectiveness of the stock and bond markets creates a basis for optimizing asset allocation when building portfolio strategies, and for issuers serves as the basis for building a strategy for issuing activities. The subject of the study is the totality of economic relations between stock market participants in the process of assessing its effectiveness and volatility in the Republic of Kazakhstan. The theoretical basis was the results of fundamental research contained in the scientific works of foreign and Russian scientists and presented in the modern literature on the problems of evaluating the effectiveness and modeling the volatility of the stock market and building investment strategies. The scientific novelty of the research lies in the development of theoretical provisions and methodological tools for assessing the effectiveness of the Kazakhstan stock market in modern conditions.
Main Instruments of Green Financing and Demand Generation in Kazakhstan
Authors: Abzhalelova S. R. , Kozhan I. U.
Published: January 2023

The main features of "green" technologies are conservation and enhancement, efficient use of natural resources. Reducing environmental pollution, preserving ecosystems and biodiversity, increasing incomes and employment of the population. it should be noted that the promotion of "green" technologies will ensure the sustainability of the regions, including at the expense of their own economic efficiency. All these factors have a positive impact on the ecological situation of the region. Green technologies were born on the basis of objective prerequisites: as a result of human activity, there was a sharp deterioration in the state of the environment, megacities and industrial zones. In the twentieth century, all spheres of human activity developed at a rapid pace. But with the evolution of modern society, the conflict has escalated between the desire of a person to live with all the possibilities of the city, and the desire of a person-a living being-to be in harmony with nature. Kazakhstan has accumulated good experience in the use of "green" technologies and obtained the first economic results. With their development, the following new concepts have entered our life: "green" investments", green "construction", green "energy, organic agriculture, etc. The widespread introduction of "green" technologies will allow Kazakhstan to enter a new path and ensure balance, as well as ensure the sustainable development of the economy of the regions. This is understandable, because the effective use of the resource can only be ensured by the wider introduction of "green" technologies.
Optimalisasi Program Layanan Khusus di Sekolah Untuk Peningkatan Kualitas Peserta Didik
Authors: Norhadiana Norhadiana
Published: January 2023

Learners are a core component of educational activities. The era of competition among educational institutions so tight as it is today, the school must strive in earnest to get learners. There is even a chairman of the foundation of education that says that seek learners is much more difficult than looking for a new teacher. Mananjemen student not only shaped data recording learners, but covers broader  aspects  yange operationally  to  assist  the  efforts  of  growth  and  development  of  learners through the process of education in schools. As a special service of learners includes guidance and counseling services, library services, a cafeteria service / kafetarian, health services, transformation services  schools,  service hostel,  and services  extracurricular, laboratory services,  and security.  A special service was held in the school with a view to facilitate the implementation of teaching in order to accomplish the goals of education in schools. Special service management is a process of providing services to the needs of learners to support learning activities for educational purposes can be achieved effectively and efficiently.
A Study to Assess the Work and Life Satisfaction among Staff Nurses
Authors:   Department of Obstetrics and Gynaecology Nursing, Sri Devaraj Urs College of Nursing, Tamaka, Kolar, Gayathri K V , Arathy S , Alanta Joy , Johny Bessy , Dhanu KS , Mathew Jeena , Mathew Maria , Paul Nayana , Revathy R , Daniel Gibson , Nagaraj .
Published: January 2023

Background: Nursing is a Profession that incorporates the generous practice of the past with the dynamic truth of today’s Health Care Industry. When we speak to Nurses, usually Majority of Nurses expresses saying “I’m thinking why I joined Nursing, I’m not satisfied in the Work I do due to various reasons like Respect, Work Place, Work Stress, Domination, Work Load, Decision Making Ability, many more. This is making my personal life disturbed and feel even my Life is not satisfied. Hence, we conducted this study with an Objective. Objective: To assess the staff nurses Work Satisfaction and Life Satisfaction, working at selected hospitals, Kolar by using Modified Minnesota work satisfaction scale & Life Satisfaction index-A questionnaire and find out the Co-relation between Work and Life Satisfaction among Staff Nurses. Methods: Descriptive Survey Research Design was used to conduct the study. 300 Staff Nurses working at selected Hospitals, Kolar were selected by using Convenient Sampling Technique. By Self-administered questionnaire data was collected using Modified Minnesota Work Satisfaction Scale and Life Satisfaction Index-A questionnaire. Data was analyzed by using Descriptive Statistics. Results: The study findings showed that, there was Positive Correlation (r=0.17) between Work and Life Satisfaction. Conclusion: This showed that Work & Life Satisfaction are interdependent and Staff Nurses who were satisfied at Work area they expressed they had Life Satisfaction. Keywords: Staff Nur
Multi detector computed tomographic evaluation of neck spaces in locally advanced oral cancers
Authors:   Department of Radio-Diagnosis, Apollo Medical College, Chittoor., Komma Siva Teja , Sakalecha Anil Kumar , Azeem Mohiyuddin S M , Darshan A V , Rajeswari . , Varshitha G R
Published: January 2023

Background: Malignancy of the oral cavity account for about 7.6% of total cancer in India. Local anatomical spread of oral cancers into the face and maxilla and further extension into neck spaces is critical for staging of cancers. Cancer staging helps in the treatment of oral cancers. CT is considered the primary modality of investigation as it helps in delineating the size and extent of primary tumor. Objective: To perform multi-detector computed tomography (MDCT) and to evaluate its usefulness in as-sessing the involvement of deep neck spaces in locally advanced oral cancers. To assess CT morphology specifi-cally to know resectability or non-resectability of oral cancers. Methods and Material: Study included a total of 39 cases of locally advanced oral cancer referred for CECT neck. MDCT findings were analyzed with regard to location, size and extent of the disease and findings were correlated with either clinical follow up or surgical findings. Results: In our study highest number of cases were of carcinoma buccal mucosa (71.8 %) followed by carcinoma tongue and lower alveolus. Most commonly involved neck space was buccal space (94.9 %). CT was 100% accurate in detecting the bone erosion. Conclusion: MDCT evaluation of neck spaces in locally advanced oral cancers is a superior diagnostic tool in tumour staging and appropriate treatment planning. Surgical management of T4b oral cancers in our study subjects showed good results with > 50% of patients showing loco-regionally controlled disease after surgery. Keywords: Computed tomography, Neck spaces, Oral, Cancers
Şeffaflık ve Hesap Verebilirlik Açısından Stratejik Planlar: Türkiye’deki Devlet Üniversitelerinin Stratejik Planlarının İncelenmesi
Authors: ÖZAKINCI Talya , SADİOĞLU Uğur
Published: January 2023

Stratejik planlama, stratejik yönetimin önemli bir aşaması olmasının yanı sıra kamu yönetiminin bilgi paylaşım araçlarından biri olarak

şeffaflık ve hesap verebilirliğe hizmet etmektedir. Bu açıdan kamu kurumlarının hazırladıkları stratejik planların şeffaflık ve hesap

verebilirliğe uyumunun ölçülmesi ve söz konusu uyumu etkileyen unsurların belirlenmesi önem taşımaktadır. Bu çalışmanın amacı,

üniversitelerin stratejik planlarında şeffaflık ve hesap verebilirliğe uyumu etkileyen faktörleri belirlemektir. Bu amaçla, Türkiye’deki 117

devlet üniversitesinin güncel stratejik planları içerik analizi yöntemi ile incelenmiştir. Çalışmadan elde edilen bulgular; stratejik planlarda

şeffaflık ve hesap verebilirliğe uyum ile üniversite yaşı, hazırlanan plan sayısı, URAP (University Ranking by Academic Performance)

sıralaması ve stratejik planlarda şeffaflık ve hesap verebilirlik ifadelerinin tekrarlanması arasında anlamlı ilişkiler tespit edilmesini

sağlamıştır. Aynı zamanda üniversitelerin stratejik planlarında şeffaflık ve hesap verebilirliğe uyum konusunda eksiklik görülen bölümler

tespit edilmiştir.
Coğrafya Bölümü Lisans Öğretim Programına İlişkin Bir Değerlendirme (Tokat Gaziosmanpaşa Üniversitesi Örneği)
Authors: BABACAN Şevki
Published: January 2023

Bu araştırmada amaç, Fen Edebiyat Fakültesi Coğrafya Bölümü öğrencilerinin eğitim ve öğretim faaliyetlerinin temelini oluşturan
bölüm öğretim programına ilişkin düşüncelerini belirlemektir. Araştırma 2019-2020 akademik yılında 37’si kadın, 18’i erkek olmak
üzere 55 öğrenciyle Tokat Gaziosmanpaşa Üniversitesi Coğrafya Bölümünde yürütülmüştür. Veriler, anket ve görüşme formu yardımıyla
toplanmıştır.
Katılımcıların genel anlamda coğrafya bölümü öğretim programını tam anlamıyla yeterli görmediği ve yoğun bulmadığı sonucuna
ulaşılmıştır. Ayrıca programının zorluğunun sınıftan sınıfa farklılaşması yanında derslerinin genelden özele gidişi ve yeterli bilgi birikimi
sağlama konusunda eksiklikleri olduğu tespit edilmiştir. Özellikle uygulama açısından öğretim programının sınırlı kaldığı ve YÖK zorunlu
derslerinin (Türk Dili, Atatürk İlkeleri ve İnkılap Tarihi, Yabancı Dil) uzaktan eğitimle verilmesinin yararlı bulunmadığı sonucuna
ulaşılmıştır. Ayrıca programda yer alan beşeri ve ekonomik coğrafya derslerinin sayı ve çeşitliliği, fiziki coğrafya derslerine kıyasla
daha yeterli görülmektedir. Öğretim programında öğrencilerin en zorlandığı zorunlu ders “biyocoğrafya”, en gereksiz görülen seçmeli
ders “Osmanlıca” olarak belirlenmiştir. Öte yandan, harita ve arazi çalışmalarının öğretim programında daha fazla yer alması gerektiği
düşünülmektedir. Öğretim programı derslerinin zorluk düzeyinin sınıf ve dönemlere dağılımı konusunda da dengesizlikler olduğu
tespit edilmiştir. Elde edilen bu sonuçların, Türkiye’deki coğrafya bölümü öğretim programı geliştirme çalışmalarına katkı sağlayacağı
umulmaktadır. Coğrafya öğretim programının iyileştirilip geliştirilmesi amacıyla gelecekte yeni araştırmalara ihtiyaç vardır.
NIST First Call for Multi-Party Threshold Schemes
Authors: Peralta René , Brandão Luís T.A.N.
Published: January 2023

The report specifies the various categories, subcategories, and requirements for a successful submission, including security characterization, technical description, open-source implementation, and performance evaluation. The process intends to help the NIST cryptographic technology group collect reference material to promote a public analysis of the viability of threshold schemes and related primitives. This will support the NIST multi-party threshold cryptography and privacy-enhancing cryptography projects in developing future recommendations.
EFEKTI VEŽBANJA NA KOGNITIVNO FUNKCIONISANJE I MENTALNO ZDRAVLJE: VEZA MIŠIĆA I MOZGA
Authors: Carrasco Páez Luis , Martínez-Díaz Inmaculada
Published: January 2023

Tokom poslednjih decenija, prednosti redovnog vežbanja za zdravlje mozga, posebno za kogniciju i mentalno zdravlje, dobro su prijavljene i u opservacionim i u eksperimentalnim studijama na ljudima. Iako su mnoge od ovih studija bile fokusirane na efekte hroničnog vežbanja kod kognitivno oštećenih subjekata, nedavna istraživanja su istakla ulogu vežbanja u poboljšanju kognitivnih sposobnosti i sprečavanju opadanja kognicije tokom životnog veka kod zdravih osoba. S druge strane, postoje značajni dokazi koji ukazuju na to da programi vežbanja mogu poboljšati ishode lečenja različitih mentalnih poremećaja, posebno onih koji utiču na raspoloženje. Međutim, mehanizmi akutne i hronične funkcije mozga poboljšane vežbanjem još uvek nisu u potpunosti poznati. U ovom kontekstu, važno je uzeti u obzir da vežba izaziva mišićne reakcije i adaptacije koje utiču na udaljena tkiva. Kao i druge sekretorne ćelije, miociti proizvode citokine i druge peptide zvane miokini koji vrše autokrinu funkciju u regulisanju mišićnog metabolizma, kao i parakrinu/endokrinu regulatornu funkciju na udaljenim organima, kao što su creva, jetra i mozak. Dakle, cilj ovog rukopisa je da ojača potencijal vežbanja kao korisnog alata za poboljšanje kognitivnog funkcionisanja i mentalnog zdravlja i kako bi preslušavanje mišića i mozga moglo da igra ključnu ulogu u ovim prednostima vezanim za vežbanje.
BLOOD LACTATE CONCENTRATION DURING A BASKETBALL MATCH
Authors: Аксовић Никола , Милановић Филип , Николић Дејан , Cristina Man Maria , Santosh Singh Laishram
Published: January 2023

Blood lactate level and heart rate are the most frequently measured physiological responses of basketball players during a game. The aim of the systematic review of the current literature was to examine the concentration of lactate during a basketball game, as well as to determine the concentration of lactate according to player position, level of play, geographical location and gender during the game. Time comparisons in separate studies revealed that lactate concentration was significantly lower in the second half than in the first. Professional players achieve higher lactate concentrations compared to semi-professional players. In addition, intrinsic and matching factors may contribute to the observed player variation, including the intensity of play prior to blood sampling, as well as the physiological preparation of the player's test sample. Blood lactate concentration is higher in Australian basketball players than in Tunisians, Spanish and British basketball players. Further research should quantify lactate concentration and heart rate in relation to active and total playing time, which is a recommendation for future researchers.
THE EFFECT OF STREET DANCE TRAINING PROGRAM ON BODY COMPOSITION OF FEMALE STUDENTS
Authors: Stošić Dejan , Uzunović Slavoljub
Published: January 2023

The aim of this research was to determine the effects of a ten-week Street dance training program on body composition in female students. A total sample of examinees consisted of 54 female subjects aged from 19 to 24 years. The subjects were divided into an experiment group (n=27) where they applied a Street dance training program for ten weeks and a control group (n=27). The experimental group subjects participated in the ten-week Street dance training program (Hip Hop and Dancehall) three times a week for 90 min. The control group subjects had regular daily activities and were not involved in any form of organized physical activity. Body composition was assessed before and after the treatment using the bioimpedance method (InBody 770). The body composition was assessed using the following parameters: body fat percentage (BF%); body fat percentage of the upper extremities (BF% Upper); body fat percentage of the lower extremities (BF% Lower); skeletal muscle mass (SMMAPS); a fat-free mass of the upper extremities (FFM Upper); a fat-free mass of the lower extremities (FFM Lower). The results of the experiment at the end of the training program showed that there is no statistical difference between the experiment and the control group. Although there were no statistical differences between the groups, the experimental group had better results in all parameters of body composition than the control group. It is concluded that the ten-week Street dance training program is not an effective model for improving body composition in female students.
EFFECTS OF TRAINING VOLUME IN FINAL RACE TIME AND NEUROMUSCULAR FUNCTION IN ULTRATRAIL RUNNERS
Authors: López-García Guillermo , Castellar-Otín Carlos , Peñarrubia-Lozano Carlos , Ortega-Zayas Miguel Ángel
Published: January 2023

The increasing status of ultratrail races due to the growth in number of races and participants in this kind of events has caught the attention and interest of the scientific community. The present study was carried out in an ultra-trail race (108km distance and 5800m of accumulated slope). The participants were divided into amateur level competitors (n=10; 43.30±4.52 years) or high-level competitors (n=10; 41.40±6.19 years). Neuromuscular response (squat jump, countermovement jump and Abalakov jump) was evaluated before and after the race. A questionary was passed to all participants before the race to determine the experience, the basal parameters and the training volume. The aim of this study is to a) determine the influence of the training volume expressed in hours per week (HS) and elevation gain (D) in the final race time; b) determine the influence of the training volume in the lower body strength loss after an ultratrail race. We establish the hypothesis that those runners who present a lower training volume spend a longer time in finishing the race and that they have a greater loss of lower body strength. Final race time and lower body strength loss were both minor in high level group. Although no significant results (p0.05) were found out.
What We Owe Owls. Nonideal Relationality among Fellow Creatures in the Old Growth Forest
Authors: Almassi Ben
Published: January 2023

Though many of us have constructed our lives (or have had them constructed for us) such that it is easy to ignore or forget, human lives are entangled with other animals in many ways. Some interspecies relations would arguably exist in some form or another even under an ideal model of animal ethics. Others have an inescapably non-ideal character – these relationships exist as they do because things have gone wrong. In such circumstances we have reparative duties to animals we have wronged because we have wronged them. Here I draw upon Christine Korsgaard’s “Fellow Creatures” (2018) and other nonideal approaches to animal ethics to critically assess the United States Fish & Wildlife Service practice of killing barred owls to protect endangered spotted owls in the old growth forest of the Pacific Northwest. This is a difficult case to be sure, but one that can benefit from non-ideal moral assessment in terms of interspecies relational repair. I argue for increased spotted owl habitat preservation and forest restoration as an alternative to barred owl removal that better aligns with both nonideal relational animal ethics and stated US Fish & Wildlife Service values.
Duality of Abuse and Care. Empathy in Sara Gruen’s Water for Elephants
Authors: Bala Moumita , Singh Smriti
Published: January 2023

In an era of Anthropocene, habitat loss and species extinction due to anthropogenic factors, and the upsurge in animal exploitation force us to reconsider the “animal question” and relationships between humans and animals. All forms of animal abuse violate the subjectivity of the animals by othering them as objects who are mercilessly exploited. Purportedly influenced by the social consciousness of the moral rights of animals and the animal advocacy movement, Sara Gruen’s novel “Water for Elephants” (2006), exposes the horrible reality of animals being mistreated for entertainment in the circus industry through a fictitious description of the events in the Benzini Brothers’ Shows. The framework of this research is based on two arguments: the crucial link between human insensitivity or empathy erosion and animal abuse; and the significance of empathy, in particular, “entangled empathy”, in acknowledging animals as moral subjects, taking care of them, and creating the harmonious human-animal relationship in the novel.
Faktor-Faktor yang Berhubungan dengan Ventilator Associate Pneumonia di Ruang Intensive Care Unit Rumah Sakit Umum Kabupaten Tangerang
Authors: Maria Yesi , Syarif Syahrizal
Published: January 2023

Ventilator Associate Pneumonia yang sering disingkat VAP adalah terjadinya pneumonia pada pasien yang telah terpasang ventilasi mekanik dengan menggunakan endotrakhea tube (ETT) dengan durasi penggunaan minimal 48 jam. Pneumonia terjadi karena infeksi nosocomial yang umumnya didapatkan dari penggunaan ventilator di rumah sakit. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang berhubungan dengan kejadian VAP pada pasien yang dirawat di ruang ICU Rumah Sakit Umum Kabupaten Tangerang. Metode penelitian ini menggunakan desain cross-sectional dengan menganalisis data skunder yaitu telaah rekam medis pasien sebanyak 120 responden. Chi square dan regresi logistik ganda digunakan sebagai uji statistik pada penelitian ini. Hasil penelitian menyatakan prevalensi responden yang mengalami VAP diruang ICU RSU Kabupaten Tangerang sebesar 6,7%. Faktor yang memiliki hubungan statistik signifikan dengan kejadian VAP antara lain usia (POR=5,28; 95% CI=1,10- 25,2) dan lama penggunaan ventilator (POR=12,2; 95% CI=1,41-105). Kesimpulan yang dapat ditarik dari penelitian ini bahwa ada hubungan antara usia dan kejadian VAP pada pasien yang dirawat diruang ICU Rumah Sakit Umum Kabupaten Tangerang
Discontinuation of antiplatelet therapy after stent-assisted coil embolization for cerebral aneurysms
Authors: Kim Tae Gon
Published: January 2023

Objective: Dual antiplatelet therapy (DAPT) is usually temporarily used after stent-assisted coil embolization (SACE), and is commonly converted to mono antiplatelet therapy (MAPT) for indefinitely. In this study, we aimed to find the possibility of discontinuing MAPT, and to determine the proper period of DAPT use.Methods: We used the Standard Sample Cohort DB dataset from the National Health Insurance Sharing Service. Among approximately 1 million people in the dataset, SACE was performed in 214 patients whose data this study analyzed. The relationship between discontinuation of antiplatelet therapy and intracranial hemorrhage or cerebral infarction was analyzed using multiple logistic regression, considering all confounding variables. The survival rate according to the continuation of antiplatelet therapy was obtained using Kaplan-Meier analysis, and the difference in survival rate according to the continuation of antiplatelet therapy was verified using the log-rank test. The hazard ratio according to continuation of antiplatelet therapy was obtained using the Cox proportional hazards model. The analysis was conducted by applying the same statistical method to the duration of DAPT use.Results: Among 214 patients who underwent SACE, 50, 159 and five patients continued, discontinued and did not use antiplatelet therapy (except at the time of procedure), respectively. In multiple logistic regression analysis, discontinuation of antiplatelet agents (including aspirin) and the period of DAPT use did not affect the occurrence of intracranial hemorrhage or cerebral infarction, considering various confounding factors. In the survival analysis according to the continuation of antiplatelet agents, patients who continued to use antiplatelet agents had a higher survival rate than those in other groups (p=0.00). The survival rate was higher in the rest of the group than in the group that received DAPT for three months (p=0.00).Conclusions: Continuation of antiplatelet agents or the period of DAPT use did not affect the occurrence of intracranial hemorrhage or cerebral infarction. Considering the survival rate, it would be better to maintain at least three months of antiplatelet therapy and it might be recommended to continue DAPT use for 12 months.
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms
Authors: Chan Gary KL , Maisel Samantha , Hwang Yeonjoo C , Pascual Bryan C , Wolber Rebecca RB , Vu Phuong , Patra Krushna C , Bouhaddou Mehdi , Kenerson Heidi L , Lim Huat C , Long Donald , Yeung Raymond S , Sethupathy Praveen , Swaney Danielle L , Krogan Nevan J , Turnham Rigney E , Riehle Kimberly J , Scott John D , Bardeesy Nabeel , Gordan John D
Published: January 2023

Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood. We used global phosphoproteomics and kinase activity profiling to map conserved signaling outputs driven by a range of genetic changes that activate PKA in human cancer. Two signaling networks were identified downstream of PKA: RAS/MAPK components and an Aurora Kinase A (AURKA)/glycogen synthase kinase (GSK3) sub-network with activity toward MYC oncoproteins. Findings were validated in two PKA-dependent cancer models: a novel, patient-derived fibrolamellar carcinoma (FLC) line that expresses a DNAJ-PKAc fusion and a PKA-addicted melanoma model with a mutant type I PKA regulatory subunit. We identify PKA signals that can influence both de novo translation and stability of the proto-oncogene c-MYC. However, the primary mechanism of PKA effects on MYC in our cell models was translation and could be blocked with the eIF4A inhibitor zotatifin. This compound dramatically reduced c-MYC expression and inhibited FLC cell line growth in vitro. Thus, targeting PKA effects on translation is a potential treatment strategy for FLC and other PKA-driven cancers.
Beta human papillomavirus 8E6 promotes alternative end joining
Authors: Hu Changkun , Bugbee Taylor , Palinski Rachel , Akinyemi Ibukun A , McIntosh Michael T , MacCarthy Thomas , Bhaduri-McIntosh Sumita , Wallace Nicholas
Published: January 2023

Double strand breaks (DSBs) are one of the most lethal DNA lesions in cells. The E6 protein of beta-human papillomavirus (HPV8 E6) impairs two critical DSB repair pathways: homologous recombination (HR) and non-homologous end joining (NHEJ). However, HPV8 E6 only delays DSB repair. How DSBs are repaired in cells with HPV8 E6 remains to be studied. We hypothesize that HPV8 E6 promotes a less commonly used DSB repair pathway, alternative end joining (Alt-EJ). Using CAS9-based Alt-EJ reporters, we show that HPV8 E6 promotes Alt-EJ. Further, using small molecule inhibitors, CRISPR/CAS9 gene knockout, and HPV8 E6 mutant, we find that HPV8 E6 promotes Alt-EJ by binding p300, an acetyltransferase that facilitates DSB repair by HR and NHEJ. At least some of this repair occurs through a subset of Alt-EJ known as polymerase theta dependent end joining. Finally, whole genome sequencing analysis showed HPV8 E6 caused an increased frequency of deletions bearing the microhomology signatures of Alt-EJ. This study fills the knowledge gap of how DSB is repaired in cells with HPV8 E6 and the mutagenic consequences of HPV8 E6 mediated p300 destabilization. Broadly, this study supports the hypothesis that beta-HPV promotes cancer formation by increasing genomic instability.
Use it or lose it
Authors: Rechnitz Ohad , Derdikman Dori
Published: January 2023

Blocking the activity of neurons in a region of the brain involved in memory leads to cell death, which could help explain the spatiotemporal disorientation observed in Alzheimer’s disease.
Boundary Aware U-Net for Glacier Segmentation
Authors: Aryal Bibek , Miles Katie E. , Vargas Zesati Sergio A. , Fuentes Olac
Published: January 2023

Large-scale study of glaciers improves our understanding of global glacier change and is imperative for monitoring the ecological environment, preventing disasters, and studying the effects of global climate change. Glaciers in the Hindu Kush Himalaya (HKH) are particularly interesting as the HKH is one of the world's most sensitive regions for climate change. In this work, we: (1) propose a modified version of the U-Net for large-scale, spatially non-overlapping, clean glacial ice, and debris-covered glacial ice segmentation; (2) introduce a novel self-learning boundary-aware loss to improve debris-covered glacial ice segmentation performance; and (3) propose a feature-wise saliency score to understand the contribution of each feature in the multispectral Landsat 7 imagery for glacier mapping. Our results show that the debris-covered glacial ice segmentation model trained using self-learning boundary-aware loss outperformed the model trained using dice loss. Furthermore, we conclude that red, shortwave infrared, and near-infrared bands have the highest contribution toward debris-covered glacial ice segmentation from Landsat 7 images.
Simplifying Clustering with Graph Neural Networks
Authors: Bianchi Filippo Maria
Published: January 2023

The objective functions used in spectral clustering are generally composed of two terms: i) a term that minimizes the local quadratic variation of the cluster assignments on the graph and; ii) a term that balances the clustering partition and helps avoiding degenerate solutions. This paper shows that a graph neural network, equipped with suitable message passing layers, can generate good cluster assignments by optimizing only a balancing term.Results on attributed graph datasets show the effectiveness of the proposed approach in terms of clustering performance and computation time.
Hybrid bayesian convolutional neural network object detection architectures for tracking small markers in automotive crashtest videos
Authors: Neubürger Felix , Gierse Daniel , Kopinski Thomas
Published: January 2023

Automotive crash tests are an important aspect of everyday safety, where accurate measurements and evaluations play a crucial role. In order to automate this process, we implement a bayesian hybrid computer vision model to detect two different kinds of target markers. These are commonly used in crash tests, by e.g. automotive manufacturers, to aid the localisation of the car’s positional data by attaching these markers at different positions to the vehicle. A tracking algorithm is subsequently used to add contextual time information to the marker objects. The extracted information can then be used in downstream tasks to calculate important metrics for the crash test evaluation, e.g. the speed, momentum, acceleration and trajectory at particular parts of the car during different stages of the crash test. The model consists of a pre-trained Faster-RCNN for the region proposals with the addition of a bayesian convolutional neural network to estimate a statistical uncertainty on the model’s classifications. This uncertainty estimation can be used as a tool to improve safety in uncertain edge cases in videos where lighting conditions and light reflections are not optimal. Our pipeline achieves an average recall and precision of 0.89 and 0.99, respectively, when applied to test data. This outperforms the recall of state of the art models like the Faster-RCNN Resnet-152 by more than 28\% while delivering slightly better precision, increasing robustness in most of the tested use-cases.
A comparison between Tsetlin machines and deep neural networks in the context of recommendation systems
Authors: Borgersen Karl Audun Kagnes , Goodwin Morten , Sharma Jivitesh
Published: January 2023

Recommendation Systems (RSs) are ubiquitous in modern society and are one of the largest points of interaction between humans and AI. Modern RSs are often implemented using deep learning models, which are infamously difficult to interpret. This problem is particularly exasperated in the context of recommendation scenarios, as it erodes the user's trust in the RS. In contrast, the newly introduced Tsetlin Machines (TM) possess some valuable properties due to their inherent interpretability. TMs are still fairly young as a technology. As no RS has been developed for TMs before, it has become necessary to perform some preliminary research regarding the practicality of such a system. In this paper, we develop the first RS based on TMs to evaluate its practicality in this application domain. This paper compares the viability of TMs with other machine learning models prevalent in the field of RS. We train and investigate the performance of the TM compared with a vanilla feed-forward deep learning model. These comparisons are based on model performance, interpretability/explainability, and scalability. Further, we provide some benchmark performance comparisons to similar machine learning solutions relevant to RSs.
Automatic Postoperative Brain Tumor Segmentation with Limited Data using Transfer Learning and Triplet Attention
Authors: Li Jingpeng , Bjørnerud Atle
Published: January 2023

Accurate brain tumor segmentation is clinically important for diagnosis and treatment planning. Convolutional neural networks (CNNs) have achieved promising performance in various visual recognition tasks. Training such networks usually requires large amount of labeled data, which is often challenging for medical applications. In this work, we address the segmentation problem by applying transfer learning to downstream segmentation tasks. Specifically, we explore how knowledge acquired from a large preoperative dataset can be transferred to postoperative tumor segmentation on a smaller dataset. To this end, we have developed a 3D CNN for brain tumor segmentation, and fine-tuned the pretrained models on the target domain data. To better exploit the inter-channel and spatial information, triplet attention has been incorporated and extended into existing segmentation network. Extensive experiments on our dataset demonstrate the effectiveness of transfer learning and attention modules for improved postoperative tumor segmentation performance when only limited amount of annotated data is available.
Popularization of Medium Maturing Orange Fleshed Sweet Potato (OFSP) Variety (Alamura) and on Farm Evaluation of Its Root Yield Performance at Halaba Zone, Weira District, SNNPR, Ethiopia
Authors: Bekele Merknehi , Debara Mekonen
Published: January 2023

Orange-fleshed sweet potatoes are one of the most important root crops for their high -carotene content, which protects against vitamin A deficiency. But in the most rural areas of the country, there is a serious health problem related to vitamin A deficiency. The associated causes of inadequate intake and production of this crop are lower adoption, weak extension support, and inaccessibility of improved varieties. For that, demonstration of a recent variety of sweet potato is a necessary action. Hence, it improves the adoption rate, creates awareness, and contributes to food and nutritional security. Accordingly, two farmer training centers and ten farmers were purposely selected to conduct the demonstration. The variety "Kulfo" was used for the experiment by using a 10m x 20m plot size for each variety. Evaluations were conducted during the mid-maturity stage, through the field day, and field visits with concerned stakeholders, beneficiaries, and surrounding farmers. Based on the result, the yield of the new variety and the standard check are 22.5 tons/ha and 10.5 tons/ha, respectively. The result shows that the yield of the improved variety has a 114.3 percent yield advantage compared to the standard check. In addition, the result of cost-benefit analysis reveals that the new variety has 65250.1 Ethiopian Birr more return than the standard check and is ranked by farmers by its disease resistance, taste, and productivity. Therefore, the new variety is recommended for further scale up in the Halaba zone and other similar agro-ecologies, and agricultural extension personnel will be encouraged to facilitate communication among farmers-researchers and vein multiple cooperatives.
Social Media Marketing Activities (SMMAs) as Stimulus on Purchase Intention with Customer Engagement as Mediator on @avoskinbeauty TikTok’s Account
Authors: Susiyanto . , Daud Ilzar , Listiana Erna , Fauzan Rizky , Hasanudin .
Published: January 2023

Aims: This research will look at the extent of the influence of Social Media Marketing Activities carried out by Avoskin Beauty to market their products so that potential; consumers are interested in buying products offered by Avoskin Beauty which are mediated by Customer Engagement.

Study Design: A quantitative approach used a questionnaire comprising 205 respondents through purposive sampling.

Place and Duration of Study: This study was taken place at Pontianak, West Kalimantan with Social Media TikTok as a background study and was conducted between July 2022 and December 2022.

Methodology: We included 205 respondents (166 female, 39 male; age range 17-30 years) who know Avoskin products through TikTok social media and follow the TikTok account @avoskinbeauty. Sampling locations were carried out by distributing questionnaires online in various cities in Indonesia.

Results: These results indicate that the t-count values for the Social Interaction, Sharing of Information, Surveillance, and Attraction variables on Customer Engagement and the effect of Customer Engagement on Purchase Intention are more significant than the t-table value of 1.96. Likewise, the p-value obtained shows a value smaller than 0.05 (α = 0.05). Based on these results, it can be stated that the variables Social Interaction, Sharing of Information, Surveillance, and Attraction have a significant influence on Customer Engagement, and Customer Engagement has a significant influence on Purchase Intention.

Conclusion: This study illustrates that marketing through social media, primarily through the TikTok platform, can be a favorable consideration for business people who want to market their products to attract broad market attention. The Social Media Marketing Activities studied have a substantial effect on giving the interest to have the intention to buy the products offered. It can be a consideration for prospective business people and interested stakeholders to create a sustainable business with relevant opportunities in the present.
Sex Determination by Metric Analysis of Coronoid and Mental Breadth of the Mandible – Nigerian Study
Authors: Edet Iboro E. , Olotu E. J. , Edibamode E. I.
Published: January 2023

Aim: This research aimed at investigating the applicability of linear measurements of Bicoronoid (BRB) and Bimental Breadth (BMB) of mandible in sex determination in four geo-political zones in Nigerian.

Study Design: A cross-sectional descriptive study was adopted for this research.

Place and Duration of Study: Anthropometric data were obtained from adult mandibles from selected medical schools across four geo-political zones in Nigeria from January to June 2021.

Methodology: 52 males and 30 females mandibles were used for this study. Bicoronoid Breadth (BRB) and Bimental Breadth (BMB) were measured using vernier caliper and data analyzed using SPSS IBM version 23.0.

Results: Descriptive analysis of BRB and BMB showed higher mean values for males 98.25mm and 45.79mm than females 90.99mm and 44.03mm respectively. Independent t-test analysis of the parameters showed significant sexual difference at 95% confident interval. The discriminant function analysis sufficiently discriminated sex and after cross-validation, BRB accurately predicted 82.7% males and 53.3% females while BMB accurately predicted 84.6% males and 26.7% females.

Conclusion: Bicoronoid and Bimental breadth measurements of mandible are recommended for sex determination in forensic investigation due to its role in sexual dimorphism.
Banking Competition and Industrialization: Evidence from Some African Countries
Authors: Raisa Tchio Tchieutsouah , Barnabé Abba Yadou
Published: January 2023

The relationship between bank competition and industrialization remains controversial and scarce in studies related to African countries. Using a sample of 26 African countries from 1996 to 2017, the objective of this paper is to analyze the effect of banking competition measured by non-structural measures (Lerner index and Boone indicator) on industrialization. Using the GMM, we obtained two different results. When measured by the Lerner index, competition evolves in the same direction as industrialization while the opposite effect is observed when using the Boone index. Following these results, we found that the relationship between bank competition and industrialization is non-linear. Bank competition should be encouraged but it should also be regulated so as not to become a brake on industrialization.
Trends in Sexual Assault Against Detainees in US Immigration Detention Centers, 2018-2022
Authors: Lue Nicole , Nwadiuko Joseph , Parmar Parveen , Zeidan Amy
Published: January 2023

This study examines sexual assault allegations perpetrated against individuals detained across US Immigration and Customs Enforcement (ICE) detention facilities from 2018 to 2022.