bluuebunny/crossref_metadata_2025 huggingface dataset:
Critical Analysis of Classical and Novel Risk Factors to Post-traumatic Stress Disorders in military populations.
Authors: Wajahath Muaaz , Pearl Elise , Pearl Adam , Elhage Kareem , Hasan Ahmad I. , Nasser Elias , Saleh Khaled
Published: July 2023

Post-Traumatic Stress Disorder (PTSD) is a mental health condition
caused by witnessing or experiencing a traumatic event. Psychological
trauma can affect vulnerable individuals, groups, communities and even
generations, and the cause of psychological trauma can be broadly
categorized as those caused by human activity or through natural causes
. PTSD heavily impacts the physical and mental health of these
individuals as well as their socioeconomic relationships. The
relationship between psychological trauma and its link with PTSD and
later suicide has been well documented in clinical literature. This
current systematic review looks at identifying and understanding the
risk factors that lead to PTSD, as well as and the association between
PTSD and suicide.. We also draw focus on the veteran population because
these military personnel are more likely to experience psychological
trauma through their professional activities like war and combat and
personal risk factors such as childhood trauma. Studies have identified
pre-, peri-, and post-traumatic risk factors. Pre-traumatic risks
include genetic predispositions, sociodemographic factors, medical
history of disease, and history of combat; peri-traumatic factors refer
to deployment experiences; and post-traumatic factors include combat
injuries, lack of social/economic support systems and medical
comorbidities. Clinical biomarkers have also been used to diagnose and
prognosticate PTSD, which we also discuss in this review. Understanding
PTSD risk factors can lead to early treatment of PTSD and, as a result,
prevent the progression to suicide.
Incomplete Cross Splitting in the Approximation of Skew-Symmetric Matrix Exponential
Authors: Mika Dariusz
Published: July 2023

This paper proposes a new splitting method for approximating the
exponential of skew-symmetric and skew-Hermitian matrix A . Our point of
departure is the splitting methods for approximation of the matrix
exponential, which we modify and combine with new low-cost analytic
formula for some sparse matrix exponential. Our motivation is to create
and test a fast exponential approximation method in the context of a
balance between speed and quality of approximation. We propose a cross
splitting of the matrix A and use it in incomplete form for reducing
computational complexity of exponential stage. We have also derived an
analytical formula for a cross-type sparse skew-symmetric and
skew-Hermitian matrix exponential, similar to the Euler-Rodrigues
relation, well known for skew-symmetric matrices in R 3 . We evaluate
this approximation problem in the context of computational cost and the
speed of the algorithms used in technology. A number of numerical
experiments conclude the optimization problem of the Independent
Components Analysis type, the results of which confirm the effectiveness
of the proposed method in technical applications.
On a case of prostatic Sarcomatoid carcinoma
Authors: Stefania Erra  , Giulia Baroni
Published: July 2023

Sarcomatoid carcinoma of the prostate is a very rare variant of prostate cancer; it generally consists of malignant glandular elements and spindle cells, while the sarcomatoid component ranges from 5 to 99 percent. It can affect both young and old, with the onset of symptoms ranging from difficulty urinating to incomplete emptying. In addition, this form of neoplasm tends to metastasize frequently to bones, lungs, and liver.
Tugas uas filsafat
Authors: Leonarfan
Published: July 2023

Belajar mencoba hal hal yang belum pernah dilakukan ada terobosan bagi penghalang kemajuan diri, mahasiswa kuat dan cerdas.
Virtual Galleries as Promising Tools for Research into Visitor Behavior
Authors: Rodriguez-Boerwinkle Rebekah , Silvia Paul
Published: July 2023

Scholars and cultural institutions have become interested in the experience that digital tools, particularly virtual gallery environments in which users navigate and interact with 3D spaces, offer visitors. However, the potential for virtual gallery tools as a resource for research into visitor behavior—as opposed to simply an end-user product aimed at museum visitors—has not been widely explored. In this methodological review, we illustrate how virtual galleries afford some new opportunities for research on the psychology of arts and visitor studies. To address this claim, we highlight the potential of virtual galleries for three research contexts related to visiting art museums. First, we discuss how virtual galleries are useful in situations where traditional museum research is not realistic or achievable. Second, we describe how virtual galleries can complement in-person work. Finally, we expand on the importance of studying virtual galleries as interesting, emerging visitor contexts in their own right.
National Identities and Images of the Other in a Canadian–American Borderlands Region: Value Difference or Borderlands Convergence?
Authors: Eagles D. Munroe , Baxter-Moore Nick
Published: July 2023

This article explores differences in national identities and orientations toward “the other” among Canadian and American students who attend geographically proximate universities in the southern Ontario/Upstate New York borderlands region. Drawing on descriptions of Canada–US cultural differences regarding national identities and views of “the other” from the work of Seymour Martin Lipset (and his critics) among Canadians and Americans at large, the authors uncover some evidence that is generally (although not universally) supportive of his characterizations. We then narrow our focus to compare the orientations of respondents who were raised in the bi-national borderlands region. Although the magnitude of difference between the views of the full sample and those of this geographically restricted group are generally not large, a multivariate test comparing scores on an additive index of cross-border affinity does show up robust evidence of increased affinity sentiments among those raised in these geographically proximate areas. Interestingly, however, the authors did not find that these heightened cross-border affinities are related to the frequency with which the individual crosses the border or to the existence of cross-border kinship networks.
APPLICATION OF CALCULATION METHODS FOR SOLVING APPLIED PROBLEMS OF HEAT AND MASS EXCHANGE IN COMPLEX SYSTEMS
Authors: LEVKIN Dmytro
Published: July 2023

The accuracy of the calculation and optimization of the objective function and its parameters when solving applied engineering problems depends on the accuracy of the formulation of the main optimization problem, calculation and applied optimization problems, as well as the accuracy of computational methods for their implementation. An increase in the considered features of applied optimization problems will complicate the setting and methods of implementing boundary value problems. Thus, for the implementation of modernized boundary value problems, it will be necessary to apply several computational methods that will create a computational structure. The main condition for constructing a physically based boundary value problem is to find and justify the conditions for the existence of a unique solution. To increase the efficiency of the use of methods of calculation and optimization of technical parameters, it is necessary to increase the number of considered features of calculation and applied optimization mathematical models for heat and mass transfer in technical systems. Along with the construction of boundary value problems, it is important to define and justify the conditions for the existence of a single solution.

The research article deals with some aspects of solving applied problems of heat and mass transfer in technical systems. Nonlocal boundary value problems for inhomogeneous and homogeneous pseudodifferential equations in partial derivatives with integral boundary conditions are considered, methods of solving a nonlocal inhomogeneous boundary value problem are proposed, and the correctness conditions of this problem in the class of infinitely differentiable generalized functions of power growth are defined and proven. Proved conditions for the existence of a correct problem for pseudo-differential equations with an integral boundary condition. The research of this article should be applied for controlling possible risks when solving applied problems in technical systems, biotechnology and veterinary medicine.
Reflexões sobre as dificuldades no tratamento da sífilis gestacional: do paciente ao sistema de saúde
Authors: Rosa Deborah Fonseca , Marques Sandy Lorrayne Rodrigues Cardoso , Caixeta Victor Fernandes Gaspar , Kallás Adriane da Rocha , Frade Rodrigo Itaboray , Oliveira Sabrynna Brito
Published: July 2023

A Sífilis, infeccção causada pela bactéria Treponema pallidum, é uma doença sistêmica, de abrangência mundial e de evolução crônica, que tem o homem como único hospedeiro. Sua transmissão pode ocorrer de forma sexual ou vertical. Os recém-nascidos de mães com sífilis não tratada ou que não realizaram o tratamento corretamente podem apresentar desde quadro assintomático até sintomas sistêmicos graves. O objetivo deste estudo foi realizar um levantameno bibliográfico sobre os fatores comportamentais do paciente e sobre as ações de saúde pública que podem interferir no tratamento da sífilis gestacional. Foram considerados artigos publicados em português, disponiveis na íntegra nos bancos de dados: Medline, Scielo, Biblioteca Virtual da Saúde (BVS), Lilacs e PubMed. Também foram considerados publicações oficiais do Ministério da Saúde publicadas no mesmo intervalo. Os resultados apontam que as principais dificuldades relacionadas ao tratamento da sífilis gestacional são: falhas e/ou ausência de acompanhamento durante o pré-natal; escassez de informação voltadas às gestantes sobre a doença; falta de acesso ao principal medicamento ou não procura por ele; adesão limitada dos parceiros ao tratamento e o uso do preservativo nas relações sexuais. Faz-se necessário adequar campanhas de prevenção e acompanhamento/monitoramento do tratamento dos casos de sífilis em gestantes para reduzir o impacto negativo na saúde pública de uma doença tratável e curável.
Congenital Cyst of the Prepuce in the Context of Phimosis: A Case Report from a Rural Setting at the Koutiala Referral Health Centre
Authors: B Ballo , O Dembélé , SI Traoré , O Koné , S Ongoiba , S Traoré , A Dembé , S Kassogué , D Kanthé , D Fomba , BM Dramé , K Mallé , A Singuepiré. , T Diarra , B Samaké , ML Diakité
Published: July 2023

Congenital cyst of the prepuce in tight phimosis is a rare condition, of which we have found no cases in the literature. The case we report concerns an 8-year-old patient with a large cyst measuring 5 cm long and 3 cm short that had been developing for six years and a very tight phimosis. The clinic was dominated by urinary problems such as burning miction, dysuria, deformation of the penis by the fluctuating penopreputial mass and psychological trauma affecting the parents, who decided to consult for better treatment. After an operative assessment, the patient was scheduled for surgery, which consisted of a cystectomy combined with circumcision, with simple immediate and long-term after-effects.
Lembaga Keuangan dan Kebijakan Publik Dalam Menangani Krisis Ekonomi Global
Authors: Hidayat Agus Rohmat , Hardianto Fery
Published: July 2023

Lembaga keuangan memiliki peran penting dalam menentukan kebijakan ekonomi untuk terus membawa sektor ekonomi pada taraf atau keadaan yang standar sehingga tidak terjadi krisis ekonomi global yang pernah terjadi pada tahun 2008. Hal ini yang mendasari penelitian untuk mengkaji lebih lanjut mengenai Lembaga keuangan dan kebijakan publik dalam menangani krisis ekonomi global. Tujuan dari penelitian ini untuk menganalisis peran lembaga keuangan sehingga dapat menciptakan kebijakan publik untuk menangani krisis ekonomi global yang dimungkinkan dapat terjadi lagi dengan belajar dari keadaan di masa lalu. Metode yang digunakan adalah jenis kepustakaan dengan mengkaji berbagai hasil penelitian juga kebijakan lembaga keuangan. Hasil penelitian menunjukkan bahwa terdapat beberapa hal yang dapat dilakukan lembaga keuangan sehingga mampu menghasilkan kebijakan publik yaitu: macroprudential dan microprudential, meningkatkan kekuatan Early Warning System (EWS), meningkatkan kekuatan protokol manajemen krisis, mendorong korporasi dalam melakukan initial public offering, Otoritas moneter dan perbankan dalam memanfaatkan berbagai peluang untuk terus menurunkan inflasi dan suku bunga khususnya suku bunga kredit sehingga lebih kompetitif di ranah dunia. Selain itu juga menggalakkan masyarakat untuk cinta produk dalam negeri dan tidak menggantungkan laju ekonomi pada sistem ekspor.
Evaluación de adherencia a la guía de práctica clínica para el manejo de faringoamigdalitis aguda en la atención de urgencias del Hospital Universitario San Ignacio, Bogotá, Colombia
Authors: Ospina-García Juan Camilo , Villegas-Echeverri María Camila , Núñez Nicolás , Rodríguez-Ruiz María Teresa , López Juliana , Gutiérrez-Maldonado Santiago
Published: July 2023

Introducción: la faringoamigdalitis aguda, independientemente de su origen, es de los diagnósticos más frecuentes en los servicios de urgencias. Aunque se ha establecido que en la mayoría de casos su origen es viral, ante la dificultad de identificar su agente etiológico con hallazgos clínicos se ha aumentado la formulación indiscriminada de antibióticos, principalmente en los servicios de urgencias, lo que contribuye con la emergencia de resistencias bacterianas y la aparición de efectos secundarios. Se propone evaluar la adherencia a la guía de práctica clínica para el manejo de faringoamigdalitis aguda en urgencias en el Hospital Universitario San Ignacio en Bogotá, Colombia. Materiales y métodos: se realizó un estudio de tipo descriptivo retrospectivo. Se revisaron 7762 historias clínicas de pacientes que consultaron por urgencias entre 2016 y 2019 por dolor de garganta. Se analizaron los datos de formulación de analgésicos, antibióticos, solicitud de la prueba rápida de detección de Estreptococo betahemolítico del grupo A (SBHGA) y el registro de la presencia de exudados al examen físico. Resultados: se incluyeron 7762 pacientes. Del total, 74,2 % recibieron antibiótico y 98 % analgesia. Se solicitó la prueba rápida de detección de SBHGA al 11,53 % de los pacientes. La presencia de exudados es el principal factor asociado a la formulación de antibióticos, y la solicitud de una prueba rápida de detección disminuye significativamente su formulación, dado que 21 % de dichos estudios fueron positivos.
Caracterización de la cirugía electiva de oído en tiempos de Covid 19 en el Hospital Universitario Clínica San Rafael
Authors: Socha Mónica , Serrano Nestor , Bernal Julian , Martínez Henry Leonardo , Alberto Prieto José , Macías Tolosa Camilo , Franco Carlos Felipe
Published: July 2023

Introducción: La pandemia por COVID-19 ha afectado la forma del ejercicio profesional médico en Colombia debido a la suspensión de las consultas y los procedimientos quirúrgicos no urgentes o prioritarios. Por este motivo, las cirugías electivas de oído se han tenido que postergar, afectando las necesidades de los pacientes con patologías otológicas. El objetivo del estudio fue evaluar la presencia de signos y/o síntomas sospechosos de infección por SARS-Cov2 en pacientes llevados a cirugía electiva de oído en HUCSR. METODOLOGÍA: Estudio observacional retrospectivo. RESULTADOS: Se realizaron 67 cirugías de oído entre el primero de septiembre del 2020 al 31 de diciembre de 2020, 64.17% fueron por oído crónico, 32.8% fueron llevados a rehabilitación auditiva con implante coclear o dispositivo de conducción ósea, tres pacientes tenían como antecedente patológico hipertensión arterial y un paciente enfermedad pulmonar obstructiva crónica, ningún paciente presentó síntomas sugestivos de COVID el día de la cirugía, ni a las 48 horas, siete y 14 días postoperatorio. CONCLUSIÓN: Los pacientes llevados a cirugía de oído en el Hospital Universitario Clínica San Rafael no presentaron signos o síntomas compatibles con infección por COVID en el tiempo comprendido del estudio, se requieren más estudios analíticos que demuestren si este tipo de procedimientos son un factor de riesgo para adquirir la infección.
Argon plasma coagulation therapy in hemorrhagic radiation proctitis following pelvic radiation in gynecological malignancies
Authors: Jain Neeraj , Mohan Jerath Amitabh , Ramita Sharma , Kanchan Sachdeva , Amandeep Kaur , Meena Sudan
Published: July 2023

Introduction:

Chronic radiation proctitis is a common chronic complication of malignant pelvic diseases after pelvic radiation therapy. Although, the incidence has decreased after advent of intensity-modulated radiotherapy due to better control of radiation dose to rectum. In the era of conventional two-field radiotherapy to pelvis, this was a common complication usually presenting after 1–2 years of treatment completion. Rectal bleeding caused by radiation proctitis is difficult to manage. Argon plasma coagulation (APC) is an electrocoagulation technique that appears to be an effective and low-cost alternative to the use of lasers in gastrointestinal endoscopy. The aim of this study was to evaluate the efficacy of APC, as well as patients’ tolerance of the procedure, in the treatment of bleeding radiation-induced proctitis.

Materials and Methods:

Between January 2015 and August 2017, 29 patients of cancer cervix treated with definite radiotherapy both external and brachytherapy who suffered from rectal bleeding due to radiation proctitis were included for treatment with argon plasma laser (APC). Twenty-three patients suffered from anemia, 16 of whom required blood transfusion. APC was performed, applying the no-touch spotting technique at an electrical power of 40 Watt and an argon gas flow of 1.5–2.0 l/min. Pulse duration was <0.5 s. Treatment sessions were carried out at intervals of 3 weeks. Subjects received 2–4 treatment sessions.

Results:

Twenty-eight out of 29 patients were accessible for effects and results. APC led to persistent clinical and endoscopic remission of rectal bleeding after a median of three sessions. No adverse effects were encountered after initial treatment. All the patients were in complete remission.

Conclusions:

APC is an effective, safe, and well-tolerated treatment for rectal bleeding caused by chronic radiation proctitis. It should be considered as a first-line therapy for radiation proctitis.
Management of surgically inoperable muscle-invasive bladder cancer in a resource constraint setting at a tertiary care center by bladder preservation protocol: Case series
Authors: Kumar Ashok , Kumar Manish , Semwal M. K. , Singh Uday , Mishra Nilima
Published: July 2023

Introduction:

Urinary bladder cancer is a major cause of morbidity and mortality worldwide. As per the data from the US cancer registry, it was diagnosed in nearly 71,000 patients and led to 14000 deaths in 2013. The Indian data in this regard are lacking with few case reports and epidemiological data only. The paucity of treatment data in this regard led us to undertake this prospective study at our radiation oncology canter. Carcinoma urinary bladder is a heterogeneous disease with variable natural history. Male preponderance and association with cigarette smoking appears to be the foremost in natural history of the disease. Our data analyzed the management of muscle-invasive medically and surgically inoperable carcinoma urinary bladder in a resource constraint setting at a tertiary care center by bladder preservation protocol (BPP).

Materials and Methods:

This prospective study was aimed to evaluate the treatment outcome in surgically inoperable muscle-invasive carcinoma urinary bladder in a resource constraint setting at a tertiary care center by BPP. All patients were treated with telecobalt 60 machine up to a dose of 60–66 Gy along with concurrent chemotherapy. Interim assessment was done at 40 Gy.

Results:

A total of nine patients were taken up for treatment with BPP. All patients were evaluated with standard evaluation protocol. All patients were followed up till any event occurred and till 6 years. Out of nine patients treated, six patients are still alive without any progression of disease and are disease free with standard evaluation on follow-up. Two patients died during the 1st year of follow-up. One patient progressed with lung and abdominal metastases 5 months after the completion of treatment and one patient was lost to follow-up.

Conclusion:

BPP using trimodality therapy is a suitable alternative to radical cystectomy in medically and surgically inoperable carcinoma urinary bladder. These patients should be highly compliant for regular follow-up, and acute and long-term toxicity should be evaluated in detail at each visit. BPP gives a ray of hope in such settings and should be done with caution. In our study, we treated all these patients in our resource constraint settings with good results and high survival rates. Our integrated team of radiation oncologists, medical oncologists, and urologists closely followed up these patients in order to optimize outcomes.
A plan comparison study between rapid arc and conventional intensity-modulated radiation treatment plans in nasopharyngeal carcinoma patients
Authors: Patidar Yaman , Kumar H. S. , Sharma Neeti , Mayilvaganan Athiyaman
Published: July 2023

Introduction:

Head and neck cancers are one of the common malignancies in Indian population. It’s entity, nasopharyngeal carcinoma is among the aggressive malignancies with its location and spread near very critical structures. Thus requires a highly conformal radiotherapy delivery techniques.

Purpose:

The aim of the study is to dosimetrically evaluate and to compare Intensity modulated radiation therapy (IMRT) plans and RAPID ARC plans for irradiation of nasopharyngeal carcinoma.

Material and Method:

A retrospective study is done on 10 nasopharyngeal carcinoma patients, who were treated with Radiotherapy at ATRCTRI Bikaner. Radiotherapy was delivered by IMRT technique (Total of 70 Gy in 33 fractions). Same patients are now planned on Rapid arc technique. Dosimetric comparison is done in terms of PTV coverage, OAR dose, conformity index, homogeneity index.

Result:

PTV coverage is similar with both the plans. Homogeneity index is higher for IMRT plans 0.119+/- 0.020 compared to 0.104 +/- 0.018 for Rapid arc plans (statistically significant).The Rapid arc plans achieved slightly better conformity 1.018+/-0.09, whereas 1.105+/-0.12 for IMRT plans. Rapid arc achieved better results for OAR, statistically significant for Brainstem (54.4 +/-10.4 Gy for IMRT and 49.7+/-4.2 Gy for Rapid Arc, Lens (Left lens and Right lens received 10.55+/-5.8 Gy and 9.44+/-9.08 by IMRT and 6.12+/-6.1 Gy and 5.45+/-6.05 Gy for Rapid Arc), optic nerves (Right and Left optic nerve received 34.36 and 35.01 Gy for IMRT plans and 30.06 and 30.05 Gy for Rapid Arc plans. However the gains are statistically insignificant for spinal cord and vestibulocochlear nerve. No major difference found for Right and left parotid between both the arms.

Conclusions:

Rapid Arc is better technique compared to IMRT for Nasopharyngeal carcinoma treatment, that provides better dose conformity, more homogeneous coverage and OAR sparing. However study is retrospective and has lesser patients, thus requires prospective study with more number of patients along with comparison of clinical outcome.
Are we providing complete drug information to its users? Status of information adequacy of package insert in India
Authors: Singhal Shubha , Shah Rima B. , Piparva Kiran G. , Dutta Siddhartha
Published: July 2023

ABSTRACT

Background:

Package inserts (PIs) serve detailed information on drug products to the users and primary care physicians, so information should be accurate, reliable, and as per the regulatory guidelines. The study aims to analyze the information adequacy of the PIs available in the Indian market as per Drug and Cosmetic Rule 1945 and US Food and Drug Administration criteria.

Materials and Methods:

A cross-sectional study was conducted on PIs collected from accessible pharmacy stores. Information provided was recorded as per criteria, and total information adequacy score (IAS) and information deficiency (IDS) score were calculated. The association of factors like single-drug/FDCs, a company of origin Indian/multinational, and route of administration (ROA) with IDS was statistically analyzed.

Results:

Of 120 PIs, 60%, 86.66%, and 73% were single-drug, prescription-drug, and drugs by Indian manufacturers, respectively. Most PIs provided generic names, ROA, and indications for use. 85%, 12%, 29.16%, and 3.33% provided information on PIs on the ability to drive, drug–food interactions, drug–drug interactions, and addiction potential, respectively. Lacking area was information on use in pediatrics–geriatrics (30%), excipients (28.3%), preclinical (15.83%), post-surveillance data (18.33%), and approval date (2.5%). There was a statistically significant difference between pharmaceutical score (3.22 vs 4.12), therapeutic score (11.5 vs 13.18), and total IAS (14.78 ± 3.39 vs 17.31 ± 2.33) of Indian and multinational companies. IDS was statistically significantly different in both pharmaceutical and therapeutic categories for single-drug vs FDCs (P = 0.00001), OTC vs prescription drugs (P < 0.05), and Indian vs multinational companies’ PIs (P = 0.00001).

Conclusion:

Numerous facets of information are lacking in PIs, and they do not impart whole information, especially of Indian origin, as per objective IDS.
Trends in oral anticoagulant use – A 10-year retrospective analysis from a general medicine department of a tertiary care hospital in south India
Authors: Thomas VV , Lenin A , George TK , Thenmozhi M , Iyadurai R , Sudarsanam TD
Published: July 2023

Background:

The prescribing practice of newer oral anticoagulants (NOACs) has not been adequately studied in the Indian scenario.

Aims:

We aimed to describe the prescribing practices of oral anticoagulants, the patient profile and medical comorbidities among patients admitted in a general medicine unit.

Methods:

In this retrospective study of the 2742 patients prescribed vitamin- K antagonists (VKAs), during the study period, 150 cases were randomly taken for analysis to match the 105 NOACs cases. Their demographic details, clinical characteristics and treatment details were analyzed.

Results:

More than 95% of anticoagulants prescribed were VKAs. The prescription of anticoagulants was more common in men (median age 63 years) for prescription of NOACs and 52 years for VKAs. Dabigatran (60.9%) and warfarin (81.3%) were the most prescribed drugs in their respective classes. The most common indication was for cardiovascular diseases with atrial fibrillation (32%). Diabetes and hypertension were the most common comorbidities in patients prescribed oral anticoagulants with a larger proportion of patients with heart failure being prescribed VKAs (P < 0.01). Patients in the NOACs group had a higher HAS-BLED high-risk score (33.3% vs. 17.3%; P = 0.002). Logistic regression analysis revealed that patients with co-morbidities of congestive heart failure were more likely to be prescribed VKAs while diabetics were more likely to receive NOACs.

Conclusions:

VKAs were the most prescribed anticoagulants; congestive heart failure, diabetes, and hypertension were the commonest comorbidities; and atrial fibrillation was the commonest indication. Patients with a high HAS-BLED score were prescribed NOACs more often.
Genesis of the Roman Catholic Church in the Fifth District of Camarines Sur: Basis for a Supplemental Material in Local History
Authors: Tino Marilou D. , Evangelista Jr. Domingo V. , Mendoza Delia V.
Published: July 2023

Roman Catholic Church involvement can be seen in all aspects of human activity. It shows how visible the Church gets involved in religious, social, political, cultural, and educational development. This qualitative-historical research was focused on determining how the Roman Catholic Churches in the six (6) Municipalities of the district came into existence. The research was backed up by interviews and observation and analysis of existing related documents. Results of the study showed that most of the oldest Roman Catholic Churches in the Fifth District of Camarines Sur were built in 1578; made of nipa and bamboo and that all of these Churches were destroyed by fire which resulted to the construction of concrete Churches which have already been improved in the present time. The Roman Catholic Churches in the Fifth District of Camarines Sur which were built during the Spanish period contributed much to the development of the district in terms of Cultural, Social, and political aspects. As a result, a reference material in teaching local History was made to address the dearth of instructional materials in teaching history from grade school to graduate education.
Native and non-native variation in adverbial and adjectival intensification: A corpus-based study of UK and Ghanaian parliamentary debates
Authors: Sarfo-Kantankah Kwabena Sarfo
Published: July 2023

Studies on the use of adverbs and adjectives by nonnative speakers of English have largely focused on learner corpus. Using Hansards of British and Ghanaian parliamentary debates as data, this paper attempts to partly fill this gap by comparatively examining the use of adverbs and adjectives as intensifiers by British parliamentarians as first/native speakers of English and Ghanaian parliamentarians as second language/non-native speakers of English. Parliamentarians’ use of adverbial and adjectival intensification is consequent on parliamentary debates being truth and validity judgement, which includes speaker involvement and commitment. While both groups of MPs employ intensifiers to strengthen their convictions and arguments, it leads to exaggeration. However, the British parliamentarians use more complex adverbs and adjectives than their Ghanaian counterparts, who use simpler forms. The paper has implications for second language teaching and learning, the theory of nativisation and the characterisation of Ghanaian English.
DESARROLLO DE CHATBOTS CON LA APLICACIÓN CHATGPT: UNA REVISIÓN BIBLIOGRÁFICA
Authors: Gordon Graell Roberto Daniel , González Águila Mari Carmen , Bultrón Batista Algis Vianor
Published: July 2023

En la actualidad el mundo está metido, quiéralo o no, en el debate sobre el ChatGPT último producto tecnológico digital, que ofrece la ingeniaría del software, basado en el desarrollo de Chatbots e inmerso en la Ingeniería Artificial que supone una máquina que “razona” para interactuar con otro usuario, que suponemos humano, en una imitación casi indetectable de otro humano. Es tal el revuelo que algunos de los más afamados empresarios de la industria digital han expresado su opinión y, no muy pocos, han pedido cautela. Este artículo es una investigación bibliográfica, cualitativa, a través de la red cuyo objetivo es indagar sobre las características de los sistemas de información Chatbots, su uso y posible desarrollo con la aplicación ChatGPT en Panamá. La principal conclusión es que es un campo abierto a la inversión y desarrollo que permite a los profesionales de la ingeniería del software nuevas oportunidades de negocio.
AVALIAÇÃO DA EFICÁCIA DA CIRURGIA DE REVASCULARIZAÇÃO MIOCÁRDICA EM IDOSOS COM DOENÇA ARTERIAL CORONARIANA
Authors: Amaral Marina Valente Coelho do , Sá Raphaela Freire de , Ambrosio Isadora Camata , Gomes Fialho Flávia , Costa Stéfany Maiolini , Mafra Caio Souza Lima , Ribeiro Joshua Leolino Gomes , Grillo Marcela de Oliveira , Barroso Taciane Miranda , Melo Ana Rafaela Guerrieri de
Published: July 2023

A cirurgia de revascularização miocárdica (CRM) tem como objetivo restabelecer a irrigação do músculo cardíaco em pacientes com obstrução das artérias coronárias (DAC). A CRM pode ser feita com o uso ou não de uma máquina que substitui o coração e os pulmões (CEC), sendo que a primeira opção é chamada de CRM sem CEC ou off-pump (OPCABG) e a segunda de CRM com CEC ou on-pump (ONCABG). A decisão sobre qual técnica usar depende de vários fatores, como o grau da DAC, a forma e o tamanho das artérias coronárias, o estado clínico do paciente e a habilidade do cirurgião. A CRM é recomendada para pacientes com DAC que afeta dois ou mais vasos ou que compromete a artéria descendente anterior na sua parte inicial, principalmente se houver comprometimento da função do ventrículo esquerdo ou isquemia grave. A CRM também pode ser mais vantajosa do que a abertura das artérias coronárias com um cateter (ICP) em pacientes com diabetes mellitus, doença dos rins ou doença dos vasos das pernas.O objetivo desta revisão é avaliar a eficácia da CRM em idosos (mais de 65 anos) com DAC, comparando as duas técnicas (OPCABG e ONCABG) em relação à mortalidade e morbidade. Para isso, foram selecionados ensaios clínicos randomizados que compararam as duas técnicas em pacientes idosos com DAC, excluindo aqueles com alto risco ou com seguimento longitudinal prolongado. Os desfechos avaliados foram mortalidade intra-hospitalar, mortalidade em 30 dias, mortalidade em 1 ano, infarto agudo do miocárdio (IAM), acidente vascular cerebral (AVC), insuficiência renal aguda (IRA), fibrilação atrial (FA), sangramento, transfusão sanguínea, tempo de internação na UTI e no hospital e qualidade de vida.Os resultados dos estudos selecionados mostraram que não houve diferença significativa entre as duas técnicas em relação à mortalidade intra-hospitalar, mortalidade em 30 dias, mortalidade em 1 ano, IAM, AVC e IRA. No entanto, a técnica OPCABG apresentou vantagens em relação à ONCABG quanto à menor incidência de FA, menor sangramento, menor necessidade de transfusão sanguínea, menor tempo de internação na UTI e no hospital e melhor qualidade de vida. Além disso, a técnica OPCABG foi associada a menor custo hospitalar e menor uso de recursos.Conclui-se que a CRM é um procedimento eficaz e seguro para o tratamento da DAC em pacientes idosos, sendo que a técnica OPCABG pode oferecer benefícios adicionais em relação à ONCABG quanto à redução de complicações pós-operatórias e melhora da recuperação funcional. No entanto, são necessários mais estudos com maior número de pacientes e seguimento longitudinal mais longo para confirmar esses achados e avaliar os desfechos clínicos a longo prazo.
Cultural and natural environment in education as support for the development of active life from early childhood
Authors: Gasparova Miroslava
Published: July 2023

The article focuses on the issue of motivation provided by school and extracurricular education of children for their active interest in the outside world. It is based on the educational concept of regional education which is present in the curriculum of primary education in Slovakia as a cross-sectional topic of educational content and is integrated in all educational areas of its curriculum in pre-primary education.
ANALYSIS OF THE ACTIVITIES OF COMPANIES PROVIDING CLOUD SERVICES IN THE DIGITAL ECONOMY
Authors: Zaripov Bahodir
Published: July 2023

In today's digital world, the modern technology of cloud computing, which many organizations and companies are paying attention to and rapidly expanding their activities, has become a real achievement of science of the new age. This article examines the decisions and decrees on the digitalization of socio-economic activities in Uzbekistan. The labor activity, the competitive position of developing IT companies in the world, the cloud services they provide, their types and the income received with the help of these cloud services over the years are analyzed. The statistics of the use of cloud services by the developed countries of the world and the situation in the use of cloud technology models are highlighted. The state of use and development trends of the hybrid cloud model in European countries are analyzed. Revenues from cloud computing services provided by large companies were carefully analyzed, including Software as a Service, Platform as a Service, Infrastructure as a Service.
ANALYSIS OF EFFICIENCY IN FINANCIAL SUPPLY MANAGEMENT OF JOINT STOCK COMPANIES OF THE REPUBLIC OF UZBEKISTAN
Authors: Abdubokiev Mukhammad
Published: July 2023

The article provides some information about the financial situation of some large joint-stock companies in the world is deeply analyzed, and based on the collected data, some suggestions and explanations are given about the methods of improving the financial support of joint-stock companies in our country and ways of their effective use.
MECHANISM TO INCREASE EMPLOYMENT OPPORTUNITIES FOR PEOPLE WITH DISABILITIES IN THE ANDIJAN REGION
Authors: Rashidov Dilovar , Rakhmatov Ziyodullo , Umarova Dilfuza , Kadirova Sharofat
Published: July 2023

A working committee formed by the Cabinet of Ministers of the Republic of Uzbekistan studied the activities of a total of 17 specialized enterprises for the disabled, including 10 enterprises for the blind, 1 society for the deaf, 3 societies of the disabled and 3 associations of the disabled in Andijan region.The article analyses the materials collected as a result of the above-mentioned research. Based on the results of the analysis, proposals and recommendations have been developed to increase the number of jobs for disabled people at 17 enterprises in the region, improve working conditions, and increase the production capacity of enterprises.
ECONOMETRIC ESTIMATION OF THE GRAVITY MODEL OF EXPORTS: A CASE OF THE REPUBLIC OF UZBEKISTAN
Authors: Islamov Bakhtiyor , Turdibaeva Munisa
Published: July 2023

In this article, the authors critically analyze the existing econometric approaches to estimating gravity models of exports from the point of view of solving such problems as taking into account zero observations, bias, inconsistency and inefficiency of estimates. As a result, the authors come to the conclusion that the method of Poisson pseudo-maximum-likelihood estimation (Poisson pseudo-maximum-likelihood, PPML) is the most preferable method for estimating the gravity export model of the Republic of Uzbekistan.
THE CONCEPT OF DIGITAL DEVELOPMENT OF HUMAN CAPITAL BASED ON ARTIFICIAL INTELLIGENCE
Authors: Goyipnazarov Sanjar
Published: July 2023

This article explores the theoretical and conceptual foundations of the digital development of human capital in the context of the introduction of digital economy and artificial intelligence. The purpose of this research is to improve the fundamental and conceptual foundations of digital development of human capital in the conditions of introduction of artificial intelligence. Based on this, the article bases the stages of human capital development from the point of view of the industry 4.0 paradigm and classifies the digital skills necessary for human capital and its development in the context of the digital economy. Also, the article reveals the transformational features of digital development of human capital in the conditions of introduction of artificial intelligence.
Weltaufgang: die Geburt des kosmologischen Denkens Eugen Finks
Authors: van Kerckhoven Guy , Giubilato Giovanni Jan
Published: July 2023

The third and fourth volumes of the ‘Phenomenological Workshop’ disclose in detail the entire mass of notes, drafts for seminars and outlines for research manuscripts that Eugen Fink left behind as a unique phenomenological legacy. They are all part of his early work, written in the years 1933 to 1945. In fact, through extensive critical revision of the philosophical principles at the heart of Husserlian transcendental phenomenology, Eugen Fink advanced slowly but steadily towards a radical ontological and cosmological renewal of phenomenology in his early notes and various research manuscripts. This book documents this ontological and cosmological renewal of phenomenology during the years 1933–1945.
RELIGIOUS HUMANISM IN ISLAMIC EDUCATION
Authors: Irhas Sya'bana
Published: July 2023

The model for creating a religious atmosphere is strongly influenced by certain situations and conditions and the application of the underlying values, namely: the structural model, the formal model, the mechanical model, and the organic model. First, the structural model, namely the creation of a religious atmosphere that is encouraged by the existence of regulations, impression building, and policies of an institution or organization and is more of a top-down nature. Second, the formal model, namely the creation of a religious atmosphere based on the understanding that religious education is a human effort to work only on the problems of the afterlife / spiritual life. Third, the mechanical model is the creation of a religious atmosphere based on the understanding that education is seen as the inculcation and development of a set of life values that work according to their function, which emphasizes moral and spiritual functions or the affective dimension rather than cognitive and psychomotor. Fourth, the organic model, namely the creation of a religious atmosphere that is encouraged by the view that religious education is a unit that develops religious views and enthusiasm for life which is manifested in religious attitudes and life skills.
Diabetes Gestacional Y Complicaciones Materno Neonatales En El Servicio De Obstetricia Del Hospital María Auxiliadora 2015 – 2017
Authors:   , Macedo Del Arca Christopher
Published: July 2023

Objetivo: Establecer la relación entre diabetes gestacional y las complicaciones materno neonatales en el servicio de obstetricia del Hospital “María Auxiliadora” 2015 – 2017. Materiales y métodos: El estudio es analítico, caso control, longitudinal y retrospectivo. Para el desarrollo del trabajo, se utilizó toda la población que respetó los criterios de inclusión y exclusión previamente elaborados. Se recolectó datos de las 144 historias clínicas, estas fueron procesadas en el programa estadístico SPSS-V25. Resultados: Los Odd Ratio mayores a 1 fueron: La Preeclampsia (p=0,023; OR= 2,5; IC: 95%), Infección del Tracto Urinario (p=0,022; OR= 2,433; IC:95%), Ruptura Prematura de Membrana (p=1,00 ; OR= 1,002 ; IC: 95), la Macrosomía Neonatal (p=0,006; OR= 4,875; IC: 95%); Prematuridad (p=0,029; OR= 3,121; IC: 95%) y el Óbito Fetal (p=0,563; OR= 1,922; IC: 95%). Conclusiones: La diabetes gestacional tiene relación, valor complicaciones materna neonatales: Preeclampsia, Infección del Tracto Urinario, Ruptura Prematura de Membrana y Macrosomía Neonatal, Prematuridad, Óbito Fetal
Creatinina Sérica En Pacientes Pediátricos Con Estatus Epiléptico O Crisis Epiléptica Atendidos En El Hospital Nacional Daniel Alcides Carrión En El Periodo De 2015-2019
Authors:   , Casimiro Roca Pier Luigi
Published: July 2023

OBJETIVO: Determinar si existe diferencia entre el valor de creatinina de los pacientes pediátricos con diagnóstico de estatus epiléptico y crisis epiléptica atendidos en el Hospital Nacional Daniel Alcides en el año 2015-2019 MÉTODO: El diseño del estudio es observacional, descriptivo y transversal. Un total de 269 pacientes conformaron el estudio, 86 fue el número de pacientes con estatus y el grupo con crisis epiléptica estuvo conformados por 183 pacientes. El análisis estadístico para determinar diferencias estadísticamente significativas se realizó aplicando la prueba U de MannWhitney. RESULTADOS: La prueba estadística Shapiro-Wilk es de 0,00. Este resultado al ser menor de 0,05 indica que el valor de creatinina no tiene una distribución normal. Las medianas del valor de creatinina de los dos grupos estatus y crisis epiléptica son 0,51 y 0,45 respectivamente. La prueba estadística U de Mann-Whitney aplicada sobre estos dos grupos es 0,454. CONCLUSIONES: No existen diferencia estadísticamente significativas entre el valor de creatinina de los pacientes pediátricos con diagnóstico de estatus epiléptico y crisis epiléptica atendidos en el Hospital Nacional Daniel Alcides en el año 2015-2019
Asociación entre los tipos de colecistectomía y sus complicaciones en pacientes atendidos en el servicio de Cirugía en el Hospital San José de Chincha 2019
Authors:   , Montes Bendezú Jhosselyn Scarlet
Published: July 2023

Objetivo: Determinar la asociación entre los tipos de colecistectomía con las complicaciones en pacientes atendidos en el Servicio de Cirugía en el HSJCH 2019. Material y métodos: La investigación es un estudio no experimental, corte transversal, retrospectivo, descriptivo correlacional, este estudio contó con una población de 200 pacientes a las que se le realizó colecistectomía convencional y laparoscópica, la muestra fue de 82 y se calculó con una fórmula para población finita. Se recopiló información mediante la revisión de historias clínicas y se trasladaron los datos a una ficha de recolección para luego ser ingresadas al programa de SPSS v.26 y el análisis de asociación se utilizó Chi-cuadrado de Pearson. Resultados: La frecuencia de los tipos de colecistectomía fueron: laparoscópica (44) 53,7% y convencional (38) 46,3%, la complicación intraoperatoria más frecuente fue: sangrado de lecho vesicular (19) 23,2% y (60) 73,2% no tuvieron complicaciones, la complicación postoperatoria más frecuente fue el dolor postquirúrgico (36) 43,9% y (33) 40,2% no presentaron complicaciones. Por otro lado, resultados del análisis bivariado entre los tipos de colecistectomía y sus complicaciones resultó con un valor de p>0.05. Conclusión: A través de los resultados obtenidos se concluye que no hay asociación estadísticamente significativa entre los tipos de colecistectomía y sus complicaciones.
Factores de riesgo asociados a prolapso genital en mujeres superiores a los 18 años de edad, atendidas en el servicio de ginecología del hospital nacional Hipólito Unanue 2019
Authors:   , Morveli Leonardo Sussy Joselyn
Published: July 2023

INTRODUCCIÓN: El prolapso genital conlleva a una variedad de inconvenientes en la salud pública por las implicaciones en contra de la salud femenina; por su variedad de consecuencias al aparato genital. OBJETIVO: identificar los factores de riesgo asociados a prolapso genital en mujeres superiores a los 18 años de edad, atendida en el servicio de ginecología del Hospital Nacional Hipólito Únanue 2019. MATERIAL Y MÉTODOS: Se trabajó un estudio observacional, analítico, corte transversal. La población total de mujeres con dicha patología es 371; la muestra alcanzada fue de 243 pacientes con prolapso genital siendo ellas el grupo de casos y 243 pacientes sin el diagnostico representando los controles. Se sacaron los datos de las historias clínicas mediante la ficha de recolección de datos. RESULTADO: se recabo que la edad tiene relación al prolapso genital p. 0.000, la obesidad (IMC>30) tiene un riesgo OR: 2.9, IC: 2.0-4.2 y p:0.000, no se obtuvo la relación con el precedente de cirugía pélvica con p>0.05. la multiparidad con respecto al número de partos tiene un OR: 2.74, IC: 1.9-3.9 y p: 0.000, el parto vía vaginal tiene un OR: 1.9, IC: 1.3-2.7 y p: 0.000. CONCLUSIONES: Los factores de edad, obesidad, precedente de cirugía pélvica, número de partos y tipo de parto en mujeres superiores a los 18 años se relacionan altamente con el desencadenamiento del prolapso genital.