bluuebunny/crossref_metadata_2025 huggingface dataset:
UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA HOW ONE OF POSSIBLE MECHANISM OF EXTERNAL HERNIAS FORMATION
Authors: Fedoseev Andrey Vladimirovich , Chekushin A A , Fedoseev A V , Chekushin A A
Published: October 2016

In the prospective study 100 patients with external abdominal hernias were observed for determine characters of undifferentiated connective tissue dysplasia. In 60 patients the 1st, 2nd or 3rd degrees of undifferentiated connective tissue dysplasia were detected. The research confirms that undifferentiated connective tissue dysplasia is significant factor for abdominal hernia formation.
PREVALENCE, SEVERITY, AND NATURAL HISTORY OF PERIODONTAL DISEASE
Authors: DMITRIEVA L A , GUREVICH K G , TEBLOEVATHE L M , Dmitrieva Lidiya Aleksandrovna , Gurevich Konstantin Georgievich , Tebloeva Laura Mikhaylovna
Published: October 2016

Throughout the 20th century, an understanding of the role of causative bacteria and the susceptible host in the initiation and progression of periodontal disease(s) has emerged from the research efforts of scientists and clinicians worldwide. The discovery of antibiotics, beginning with sulfanilamide, penicillin, and streptomycin, led to additional strategies for managing periodontal disease. With the discovery of the mechanism of action of aspirin, scientists began to develop new strategies for treating diseases that focused on controlling inflammation. Thus, host-modulating therapies emerged for the management of periodontal disease through the control of inflammation.
Investigation of a force component economic safety in pharmacy
Authors: Kuznetsov Dmitriy Anatol'evich , Kuznetsov D A
Published: October 2016

The author considers a force component of pharmaceutical economic safety. On the basis of the principle of subsidiarity the system of a quantitative estimation of force component economic safety of the pharmaceutical organization, a matrix of security of a force component is offered. In work major factors of a force component are studied, significances of weight factors with use of the theory of fuzzy sets are established.
RESULTS Development of techniques chromatospectrophotometrical DEFINITIONS AND GERINIARINA umbelliferone In the grass GRYZHNIKA polyadelphous
Authors: Akul'shina E V , Darmogray V N , Akulshinа E V , Darmohray V N
Published: October 2016

Based on the study and systematization of data in the literature concerning the taxonomic and chemical characteristics, the results of its own analysis of the quality of the grass gryzhnika polygamous (Herniaria polygama J. Gay.), For these materials the authors developed a method of determining the content chromatospectrophotometrical herniarin and umbelliferone, which can be used to develop and completion of regulatory documents on the grass gryzhnika polygamous.
Influence of Amelanchier Medic polysaccharide on blood of healthy animals
Authors: Laksaeva E A , Sychev I A , Rodina E V , Denisova Z I , Laksaeva E , Sichev I , Denisova Z , Rodina E
Published: October 2016

The soluble polysaccharide complex induces erythropoesis by increasing the rate of erythrocytes and hemoglobin in blood of experimental rats and changes the concentration of lymphocytes, leucocytes and monocytes. The following changes occur in blood of the experimental animals: increase in the rate of iron and iron-binding properties of serum as well as change in the rate of protein fractions. Polysaccharide of Amelanchier Medic causes the increase in the mass of spleen and changes in the mass of thymus of healthy animals.
ONE - HUNDREDTH ANNINERSARY OF THE INTRAVENOUS ANESTHESIA CREATION
Authors: Uzbekova Dinara Galievna , Uzbekova D G
Published: October 2016

In 2010 we celebrate the anniversary of intravenous anesthesia, which was invented 100 years ago. Professor N.P. Kravkov (1895-1924) was the first to suggest the use of intravenous anesthesia of gedonal in clinical practice. After successful tests of this anesthesia he suggested a new method of combined anesthesia: inhalation of chloroform for maintenance of anesthesia after intravenous agent gedonal administration
VARIABILITY OF ADAPTABLE RESERVES OF THE HUMAN ORGANISM DEPENDING ON GENERAL NONSPECIFIC REACTIVITY LEVEL OF THE ORGANISM
Authors: Postnova M V , Mulik Yu A , Novochadov V V , Mulik A B , Postnova M V , Mulik Y A , Novochadov V V , Mulik A B
Published: October 2016

The general nonspecific reactivity level of the organism (GNRLO) as the factor of individual stress resistance of the person was characterized during an experimental research. Based on the analysis of cardiovascular system activity, formation mechanisms of adaptable reactions, indicators of lipid's peroxidation it was defined that individuals with high GNRLO have low stress's stability; individuals with low GNRLO have high stress's stability; and persons with average GNRLO have intermediate (average) expressiveness of stress's stability.
THE PECULIARITIES OF REPRODUCTIVE BEHAVIOR AND HEALTH OF WOMEN LIVING IN THE COUNTRYSIDE
Authors: Pristupa Evgeniya Mikhaylovna , Pristupa E M
Published: October 2016

In this article we can see the results of study of reproductive behavior and health of women living in the countryside and the difference of the quality of obstetric-gynecologic care at the rural health care area with different level of qualification of specialists. The research gave significant differences in reproductive behavior of women living in the count ryside.
Possibility for hardware and software KAPNOGRAFICHESKOGO COMPLEX KP-01 ELAMED "in the diagnosis of ventilation disorders in patients with bronchial asthma
Authors: Kuspanalieva D S , Rakita Dmitriy Romanovich , Byalovskiy Yuriy Yul'evich , Kuspanalieva D S , Rakita D R , Byalovsky Y Y
Published: October 2016

The presence of hyperventilation syndrome (HVS) is a very acute problem in the asthmatic patients. It can result into diagnostic mistakes, inadequate therapy and worsening the quality of life. So making a diagnose of HVS is of great importance. Thus 90 were investigated (60 - experimental group and 30 - the group of control). It was revealed asthmatic patients to have HVS more often.
ISSUE ABOUT THE PREVENTION OF THE PULMONARY ARTERY'S THROMBOEMBOLISM AT PATIENTS WITH DEEP VENOUS THROMBOSIS OF LOWER LIMBS
Authors: Agafonova Lyubov' Viktorovna , Zaikina Natal'ya Viktorovna , Chernykh A V , Agafonova L V , Zaikina N V
Published: October 2016

Floating thromboses of the deep venous thrombosis of lower limbs are dangerous by embolism and often provoke the pulmonary artery's thromboembolism. In the modern period ultrasonic scanning of veins is the method of the final instrumental diagnostics. Identification of floating thrombus is the indication for emergency operative intervention. 710 researches were conducted, 21 floating thromboses of the deep venous thrombosis of lower limbs were detected. Supplementary methods of diagnosis confirmation and detection of indications for emergency operative intervention weren't.
Deficit of social cognition in schizophrenia: research and perspectives
Authors: Rychkova Ol'ga Valentinovna , Rychkova O V
Published: October 2016

The review observed traditional and modern approaches to this subject. The author demonstrated that deficits of social cognition were the subject of interest in many research in patients with schizophrenia. Deficits of social cognition have been found in patients with schizophrenia and these deficits may in fact be central and be relatively stable across the course of the illness. The author demonstrated some types and models of deficits of social cognition, and describe them lake a specific pattern in schizophrenia. Specificity and stability of deficits of social cognition in schizophrenia, as well as their relation to social functional outcome, is sure to have far-reaching implications for the treatment and rehabilitation of people with the disorder. It is the biggest perspectives of this subject
Medico-social importance of informational and educational work with schizophrenics' relatives
Authors: Khritinin D F , Petrov D S , Konovalov Oleg Evgen'evich , Hritinin D F , Petrov D S , Konovalov O E
Published: October 2016

The article regards the issues of improvement of informational and educational help for families of schizophrenics. There was made an inquiry of relatives of mentally sick persons being treated at Ryazan regional clinical mental hospital. We estimated the level of knowledge of tested people concerning the methods of treatment, means of prevention of exacerbation, their role in the process of treatment. We marked the importance to estimate the awareness of patients' relatives and the necessity to raise the quality and efficiency of specialized help with the use of educational programs.
CHANGE OF A CONDITION OF A MEAL OF CHILDREN IN YEAR SUPERVISION AT TRANSITION FROM PRESCHOOL TO SCHOOL
Authors: Korolev Aleksey Anatol'evich , Perelygina O V , Kon' I Ya , Nikitenko E I , Shilina N M , Korolev A A , Perelygina O V , Kon I Y , Nikitenko E I , Shilina N M
Published: October 2016

By results of material gathering for the year period of supervision, the data about a condition of a food integrated group of children into which 101 child has entered has been studied: 50 (49,5 %) boys and 51 (50,5 %) the girl.
At week-days at younger schoolboys (children of 7 years) in comparison with preschool children (children of 6 years) consumption of milk and liquid dairy products, bread rye and wheaten, oils creamy and vegetative has authentically decreased, at authentic increase in consumption of sausage products and confectionery products. Change in structure of a grocery set became the reason of decrease in receipt with a diet starched полисахаридов, beta-carotin, vitamins E, C, В2, В6, РР, В1, phosphorus, iodine and magnesium and increase of receipt of fat as the general, and an animal, mono- and disaccharides, and including the added sugar.
THE ALGORITHM OF OBJECTIVE EVALUATION RESULTS OF TREATING PATIENTS WITH NEUROCIRCULATORY DYSTONIA: SUBSTANTIATION AND EXPERIENCE
Authors: Sokolov S A , Sokolov S A
Published: October 2016

The article presents the scientific and methodological substantiation of the algorithm of objective evaluation of treating patients with NCD, based on the scoring of the dynamics of subjective symptoms, physical and instrumental examination, autonomic homeostasis and general functional reserves. Usefulness of the algorithm is proved in practice by evaluating results of treatment of 120 patients with hypertensive, hypotensive and cardiac forms of NCD.
PRIMARY PREVENTION OF THE ACUTE CEREBRAL CIRCULATION STROKE:ROLE OF THE MODERN DIAGNOSTIC TECHNIQUES
Authors: Agafonova Lyubov' Viktorovna , Zaikina Natal'ya Viktorovna , Agafonova L V , Zaikina N V
Published: October 2016

Summary: 24-hour blood pressure monitoring has been performed in 40 patients aged from 17 till 24 with the normal and raised clinically arterial blood pressure. Differences between groups have been revealed, correlation of clinical arterial blood pressure and results of 24-hour monitoring has been confirmed, and individual cases of their discrepancy have been also described. Appropriate and proper diagnosis may reduce probability of stroke in these persons in the future.
Dissection of tissues in Endosurgery for obesity: EXPERIMENTAL ANALYSIS OF ligated
Authors: Ivanov V V , Puchkov K V , Osipov A V , Ivanov V V , Puchkov K V , Osipov A V
Published: October 2016

In the accomplished prospective research was fulfilled a comparison between ForceTriad LigaSure-V and Harmonic Scalpel in the circumstances of pretending intraabdominal environment according to lateral heat diffusion, ligation time, burst pressure, intensiveness forming high dispersive aerosol. On isolated vessels FT LS-V has shown the best burst pressure and the shortest ligation time. While using Harmonic Scalpel there was the least effect of lateral heat diffusion and the least smoke. In the state of obesity is held the reliability of the vessel ligation by increasing lateral heat diffusion and intensively of the smoke forming.
Influence of Amelanchier Medic polysaccharide on animal physical activity
Authors: Laksaeva E A , Sychev I A , Laksaeva E , Sichev I
Published: October 2016

Polysaccharide water soluble complex produced from green fruit of Amelanchier Medic increases physical activity, contributes to the growth of muscle weight, increases the number of erythrocytes and the amount of hemoglobin in experimental animals.
OPTIMIZATION OF THE EXTRACTION IN PRODUCTION TINCTURES cottonweed TOPYANOY
Authors: Nikolashkin A N , Vesnov I G , Selezenev N G , Popov D M , Nikolashkin A N , Vesnov I G , Drake N G , Popov D M
Published: October 2016

With the help of variance analysis showed the most significant technological factors affecting the yield of biologically active compounds from herbs cottonweed topyanoy.
VALUE INTERCELLULAR interactions, extracellular matrix and vascular FACTOR IN THE DEVELOPMENT OF BREAST TUMORS
Authors: Kakturskiy L V , Mnikhovich Maksim Valer'evich , Ternov Maksim Mikhaylovich , Kaktursky LV , Mnihovich M V , Ternov M M
Published: October 2016

In the article on the basis of a literature review addresses current understanding of the genesis and the role of cell-cell interactions, vascular factors and extracellular matrix in a multi-step process of tumor progression. Tumor progression is characterized by increased genetic damage to cells and the growth of heterogeneity of genotypic basis, increased capacity for invasion, angiogenesis, metastasis. The importance of vascular factors in the development of breast cancer.
N.I. Pirogov - DOCTOR, CITIZEN, THE GREAT SON OF RUSSIA(To 200 anniversary of the birth of N.I. Pirogov)
Authors: Mnikhovich Maksim Valer'evich , Kakturskiy L V , Vernigorodskiy S V , Kaminskaya N A , Miglyas V G , Mnikhovich M V , Kakturskiy L V , Vernigorodsky S V , Kaminska N A , Miglyas V G
Published: October 2016

The article analyzes the work N.I. Pirogov, which formed the foundation for the development of modern trends of Medicine. Works N.I. Pirogov covered a wide range of critical issues of clinical and theoretical medicine, pathology, pathological anatomy, such as clinical and biological analysis of inflammation, suppuration, bone pathology, infectious diseases and their control. Much attention N.I. Pirogov on experimental studies on the development of collateral circulation, pathology, wound healing, shock, on plastic surgery. N.I. Pirogov - creator of the topographic (Surgical), anatomy, health organizer, scholar-thinker, and teacher.
THE INFLUENCE OF THE FETAL INFLAMMATORY RESPONSE SYNDROME ON POSTNATAL ADAPTATION OF THE NEWBORNS
Authors: Sergeeva Vera Alekseevna , Shabalov N N , Aleksandrovich Yu S , Nesterenko S N , Sergeeva V A , Shabalov N P , Alexendrovich Y S , Nesterenko S N
Published: October 2016

The fetal inflammatory response syndrome associates with inflammation in placenta which expansion determinates the course of neonatal period. The authors show the role of the inflammation of the fetal part of placenta in the development of systemic fetal inflammatory response syndrome, endothelial activation and neuro-endocrine-immune imbalance. It is possible to conclude that this disorders play important role in manifestation of the clinical symptoms of antenatal infection in the early neonatal period.
MORPHOFUNCTIONAL STATUS OF THYROID GLAND OF SIMVASTATIN AT EKSPERIMENTAL HYPOTHYREOSIS
Authors: Popova Natal'ya Mikhaylovna , Yakusheva E N , Shchul'kin A V , Chumachenko P A , Popova N M , Yakusheva E N , Shulkin A V , Chumachenko P A
Published: October 2016

In article data of the research devoted to studying of action of simvastatin on morphofunctional status of thyroid gland at experimental hypothyreosis are resulted. It is shown that experimental hypothyreosis is accompanied by lowering of level Т4, rise of level ТТH and kompensatorno-adaptive changes in morphological structure of a thyroid gland. Simvastatin at experimental hypothyreosis at first reduces, and then increases functional activity of thyroid gland that leads to an expedition of restoring of function of organ.
ELLABORATION AND EFFICATIVE ANALYSIS OF THE QUALITATIVE AND QUANTITATIVE ESTIMATION OF THE HUMAN REQUIREMENTS
Authors: Mulik A B , Postnova M V , Mulik Yu A , Novochadov Valeriy Valer'evich , Mulik A B , Postnova M V , Mulik Y A , Novochadov V V
Published: October 2016

Resulting from the generalisation of existing approaches to an estimation of the human requirements the universal technique was developed. It allows to define separatelly the quantitative expressivenesses of physiological requirements, requirements for safety, reproductive, social, requirements for education, requirements for self-realisation, uniting them in two groups, characterised by the centripetal beginning and focused on an involvement into society. The expediency of calculation of two derivative indicators was proved: level of requirements's actualisation and success's installation of result's achievement. The interrelation of the developed indicators with main psychophysiological and psychological characteristics of the person were proved.
EFFECT OF ENVIRONMENTAL CONDITIONS ON ANTHROPOMETRIC GIRLS INDICES
Authors: Berestenko E D , Zheltikov A A , Grigor'ev Yuriy Ivanovich , Berestenko E D , Zheltikov A A , Grigoryev Y I
Published: October 2016

Summarizes the results of the study of anthropometric indicators of girls 17-18 years old. Submitted by the dynamics of these parameters in 750 students of the pedagogical institute, depending on environmental conditions of their places of permanent residence. Most disharmonious development of girls found among tulyachek, and among them the predominant type of development underweight. Sharply disharmonious development of girls mostly among the residents of Tula, and less number they found among the surveyed students living in the Eco-zone "north. The greatest number of girls with normal IMT were living in an environmentally prosperous north-west region, much less their identified among residents of the environmentally disadvantaged south-east region.
SANITARY - HYGIENIC CHARACTERISTIC OF WORKING CONDITIONS AND THE STATE OF HEALTH OF WORKERS OF THE ENTERPRISE OF MECHANICAL ENGINEERING
Authors: Nikitin A S , Nikitin A S
Published: October 2016

Working conditions in forge-and-press and foundry manufactures on many hygienic indications exceed admissible parameters that can negatively affect on health and state of health of workers. Profound studying of technological process, factors of the industrial environment have allowed to estimate working conditions of workers of studied shops according to modern representations on weight and intensity, harmfulness and danger with an estimation of risk of development of a pathology as a result of influence of factors of the industrial environment.
FEATURES folliculogenesis IN THE THYROID GLAND IN RATS UNDER THE INFLUENCE OF SALTS OF HEAVY METALS
Authors: Romanyuk A M , Moskalenko R A , Logvin A V , Romanyuk A M , Moskalenko R A , Logwin A V
Published: October 2016

The purpose of this study was to investigate the mechanism of folliculogenesis in the thyroid gland under the influence on the organism combinations of salts of heavy metals. The study was conducted on 24 white laboratory rats. By mathematical simulation showed that in the wall of the follicle ellipsoid greater tension arises from the longitudinal section of an ellipse and a cross-sectional voltage decreases. Draws attention to the important role intraluminal colloidal pressure in the process of folliculogenesis. The paper makes the assumption that the difference between peripheral and central folliculogenesis arises from the different values intraluminal pressure, which in turn is derived from different functional activity of the follicular epithelium.
KEY ASPECTS OF UROLOGICAL SKILLED MEDICAL CARE TO PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA
Authors: Sevryukov Fedor Anatol'evich , Kamaev Igor' Aleksandrovich , Grib Maksim Nikolaevich , Perevezentsev Egor Aleksandrovich , Sevryukov F A , Kamaev I A , Grib M N , Perevezentsev Y A
Published: October 2016

The article deals with the issues of providing patients with benign prostatic hyperplasia, high quality urological care, touched upon some aspects of improving health care to such patients
OPERATIONS AS procatarxis RECURRENCE THYROIDITIS Subacute de Quervain
Authors: Aristarkhov Roman Vladimirovich , Aristarkhov R V
Published: October 2016

This article provides an interesting case from practice of surgery on the thyroid was the cause of subacute thyroiditis de Quervain. The author proposes a new method for treating this disease with the help of low-intensity laser radiation
Age-related changing of the skull and human brain structures on MRI evidence
Authors: Pavlov Artem Vladimirovich , Pavlov A V
Published: October 2016

The results of makromorfometric research, whose goal was to obtain reliable informationon the association between linear dimensions of the mamillary bodies, the skull and some brain structures of people in different sex and age
INDIVIDUAL DIFFERENCES OF TARGET ORGANS REACTION OF WISTAR RATS TO ACUTE BACTERIAL ENDOTOXICOSIS
Authors: Kosyreva A M , Soldatov D I , Vasil'eva S G , Kosyreva A M , Soldatov D I , Vasil'eva S G
Published: October 2016

Individual morphofunctional differences of target organs of Wistar rats to acute endotoxicosis, induced by lypopolisaccharide (LPS) administration in high dose were investigated. By cluster analysis of target organs and cytokines characteristics Wister rats were divided into two groups - with high and low production level of Th1 cytokines. In 24 hours after LPS administration hepatic dystrophic changes and lung inflammation in rats with low level of Th1 cytokines (IL-2, IF-γ) were more expressed than in rats with high level of Th1 cytokines. In 7 days individual morphofunctional differences were less expressed and mainly were found out on functional level
MOTIVATION OF STAFF - FUNDAMENTAL FACTOR IN THE CONTINUOUS MEDICAL EDUCATION AND QUALITY IMPROVEMENT OF MEDICAL CARE
Authors: Breusov A V , Bershadskaya M B , Breusov A V , Bershadsкay M B
Published: October 2016

Health protection is one of priority problems of social policy of the state. The present stage the special urgency is got with questions of quality of medical aid which cannot be considered separately from questions of preparation of experts and a supply with information during training and professional work, creation of system of motivation to increase of an educational level and rendering of qualitative medical services to the population, continuous education of medical workers of all levels. System of public health services one of complex branches of the national economy, demanding capital investments and change of personnel selection concerning the medical personnel.
MEDICAL AND SOCIAL RISK FACTORS OF FAILURE born in families enter into a legally MARRIAGE
Authors: Medvedeva O V , Medvedevа O V
Published: October 2016

In this paper, using multivariate analysis techniques to identify the causes of infertility in the families living in a legal marriage, a classification that includes risk factors for infertility, which allowed us to determine the hierarchy of power and their effects.Identify the reasons why families remain childless, will determine a reserve of births, to develop measures to enhance the effectiveness of conservation management of reproductive health and family policy measures on different hierarchical levels
MAIN TRENDS OF PERSONNEL-potential in conditions of modernization of the Regional HEALTH (FOR EXAMPLE RYAZAN domains-TI)
Authors: Bol'shova T V , Bolshova T V
Published: October 2016

The article characterized the main directions of development of human resources capacity of the health sector in its modernization. Presents a strategy of personnel policy in the health of the major issues in the management of human resources areas and suggest ways to create a single mobile system management training, retraining and advanced training of medical personnel to work in inter-regional malls.
Volume and character of laboratory researches at hospitalization concerning reumatical arthritis
Authors: Zhukova Nadezhda Valer'evna , Zhukova N V
Published: October 2016

In article results of the analysis of volume of actually executed laboratory researches among hospitalized concerning different forms reumatical arthritis are resulted. The expert estimation of the laboratory researches, the patients executed to a given contingent is given
To a question on health of children living in the poorcountryside families
Authors: Lebedev Denis Yur'evich , Lebedev D U
Published: October 2016

In article the data characterizing separate parameters of health of children, living in poor and financially safe families of countryside is presented. The research volume has made 300 families, including 150 basic and 150 control groups. The data has been included in working out, concerning chest feeding, a mode and character of a food and an estimation of health of children parents.
Case management with severe out-patient form of pneumonia audit at the in-patient
Authors: Almazova E V , Almazova E V
Published: October 2016

The aim of this paper is to evaluate the validity of case management of severe out-patient form of pneumonia using the indicators of quality at the in-patient departments in Ryazan. This audit was carried out on the basis of 102 patients data hospitalized to the in-patient departments in Ryazan in 2005-2009 years period. The mean age of patients was 51,85±1,68 years, 61 patients were males and they predominated over females (59,8%). The indicators of quality were taken by us because they have already proved their reliability in Russia and abroad. Initial antibacterial therapy (70,6%) didn't meet modern clinical recommendations. In less than half cases IV antimicrobial injections were used. Only in 24% of cases we gave step-down antimicrobial therapy. The method of clinical scaling to estimate the severity of patients condition was not applied, only in 24,5% of cases we used pulseoxymetry to find out the stage of hypoxemic abnormality
Сomparative characteristics of induced sputum cellular composition in patients with mild and moderate stable COPD, patients with chronic bronchitis and smokers
Authors: Medvedev I D , Ishina T I , Makarova O V , Makhnach G K , Nikonova E V , Sidorova E I , Podzolkov V I , Medvedev I D , Ishina T I , Makarova O V , Nikonova E V , Mahnach G K , Sidorova E I , Podzolkov V I
Published: October 2016

Comparative characteristics of induced sputum cellular composition in 11mild and 12 moderate stable COPD patients, 30 patients with chronic bronchitis and 13 smokers have been studied. Patients with mild stable COPD were found to have increased absolute number of all cells, including neutrophils and macrophages in the induced sputum in comparison with patients with chronic bronchitis. The inflammatory process in the lungs increases along with airflow limitation degree
SPIROMETRY SCREENING IN EVALUATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AT PRIMARY CARE
Authors: Kotlyarov Stanislav Nikolaevich , Kotlarov S N
Published: October 2016

Chronic obstructive pulmonary disease is an acute medical and social problem. Spirometry is a "gold standard" of diagnostics of the disease. In our investigation we studied respiratory function in rural population. A high prevalence of obstruction: FEV1 less than 80% of normal, recorded in 23.5% of the cases and FEV1/FVC
SOME ASPECTS OF THE PSYCHOLOGY OF PATERNITY
Authors: Pastukhova Marina Vladimirovna , Pastuhova M V
Published: October 2016

The article is devoted to an actual problem- psychological peculiarities of one new formation of adulthood-paternity. The author considers some aspects of the relationships between children and fathers, studies peculiarities of the fathers' educational influences into children, investigates typology of fatherhood. In this article the author also presents a model of development of fatherhood. The given information of this report may be useful in the system of children upbringing in a family and in the consultative work of a psychologist.
A STATISTICAL APPROACH TO HYGIENIC ASSESSMENT OF DRINKING-WATER DYNAMICS IN THE TERRITORY
Authors: Pozdnyakova Marina Aleksandrovna , Fedotova Irina Viktorovna , Lipshits Dmitriy Aleksandrovich , Koroleva Tat'yana Aleksandrovna , Pozdnyakova M A , Fedotova I V , A Lipschitz D , Koroleva T A
Published: October 2016

Poor quality of drinking water poses a threat to public health, what determines the absolute importance of objective and complete assessment of water quality, the choice of indicators and methods of calculation based on statistical methodology. The proposed statistical approach for assessing the hygienic quality of drinking water areas in the dynamics is innovative because it allows to simulate and forecast trends in the quality of water areas, distinguished statistically significant fluctuations in health indicators.
REPRODUCTIVE HEALTH OF WOMEN LATE ФЕРТИЛЬНОГО AGE AS THE MEDIKO-SOCIAL PROBLEM
Authors: Kiselev Anton Mikhaylovich , Konovalov Oleg Evgen'evich , Kiselev A M , Konovalov O E
Published: October 2016

In article the characteristic of modern lines of gynecologic disease and reproductive health of the female population of Russia is resulted. Risk factors of reproductive losses at women late фертильного age are considered. The estimation of the developed structure of akushersko-gynecologic service in the country is given.
THE METHOD ELECTRONIC AUSKULTATII: USE CHILDREN FOR THE DIAGNOSTICS OF THE BRONCHIAL ASTHMA
Authors: Dmitriev Andrey Vladimirovich , Filimonova Tat'yana Anatol'evna , Sharovskaya Galina Ivanovna , Dmitriev А V , Filimonova Т А , Sharovskaja G I
Published: October 2016

In article are presented results of the using the method electronic auscultations beside healthy and children with bronchial asthma. They Are Shown comparative features sound parameter, relationship of the standard methods of the study (the spirometry, peakfloumetry) and method electronic auscultations. Will Revealled diagnostic value given method in group детей with bronchial asthma.
SUICIDAL, NARCOLOGICAL AND PERSONAL-PSYCHOLOGICAL PECULIARITIES OF MEN SUFFERING FROMALCOHOL DEPENDENCE MARRIED TO WOMEN HAVING SUICIDAL ACTIVITY
Authors: Merinov Aleksey Vladimirovich , Shustov Dmitriy Ivanovich , Merinov A V , Shustov D I
Published: October 2016

The article studies the influence of suicidal activity of wives on suicidal, narcological indexes and experimental-psychological
specifications of their husbands suffering from alcohol dependence. It has been found out that men suffering from alcohol
dependence married to women having suicidal activity as distinct from men suffering from alcohol dependence married to
women without suicidal activity reveal suicidal activity more frequently (phenomenon of suicidal matrimonial comorbidity).
They also reveal non-suicidal behavioral patterns more frequently and prosuicidal predictors are quite common in them.
TREATMENT-DIAGNOSTIC TACTICS AT NON PALPABLE BREAST LESIONS
Authors: Kulikov Evgeniy Petrovich , Yukhanov Sergey Vladimirovich , Zagadaev Aleksey Petrovich , Sashina Ekaterina L'vovna , Kulicov E P , Juhanov S V , Zagadaev A P , Sashina E L
Published: October 2016

In article results of inspection of 27 patients with non palpable breast leaseons are presented. To all patients the fine needle aspiration biopsy (FNAB) non palpable breast lesions under control of ultrasonic with the subsequent cytologic research was spent. Operative treatment is spent to 11 patients (41 %), in 11 cases (41 %) dynamic supervision is recommended, to 5 patients (18 %) conservative therapy is appointed. The informative material for cytologic research is received at 14 patients. Thus in
51 % of cases it was possible to get morphological verification from non palpable breast lesions.
RISK OF PULMONARY EMBOLISM ASSOCIATED WITH SUPERFICIAL VEIN THROMBOPHLEBITIS
Authors: Kalinin Roman Evgen'evich , Narizhnyy Mikhail Vyacheslavovich , Suchkov Igor' Aleksandrovich , Kalinin R E , Narizhniy M V , Suchkov I A
Published: October 2016

This article represents the evaluation of risk of pulmonary embolism associated with superficial vein thrombophlebitis based on observations in more than 500 patients.We found that acute thrombophlebitis was associated with varicose veins stage C3 to C6 of the CEAP classification in 30% cases and varicose veins with insignificant valve insufficiency verified by duplex ultrasound scan in 35% patients. During the surgical operations we found thrombosis extending to the saphenofemoral junction in 90 patients (17.8%) while in 35 patients the thrombi were found in femoral vein. Thus 24.7% of patients were at high risk of pulmonary thromboembolism.
SEMAX INFLUENCE ON RAT CARDIOMYOCITE APOPTOTIC CELL DEATH IN IRREVERSIBLE ISCHEMIA AND ISCHEMIA-REPERFUSION
Authors: Berdalin Aleksandr Berikovich , Gavrilova Svetlana Anatol'evna , Golubeva Anna Valer'evna , Buravkov Sergey Valentinovich , Koshelev Vladimir Borisovich , Berdalin A B , Gavrilova S A , Golebeva A V , Buravkov S V , Koshelev V B
Published: October 2016

5 groups of male rats were investigated: control group; irreversible ischemia with drug and without; the animals with reperfusion after 2.5 hours of ischemia with drug and without it. Samples for light microscopy (haematoxylin-eosin and TUNEL-analysis) of the risk area (anterior wall of left ventricle) and conditionally intact myocardium (lateral wall and interventricular septum) were taken 72 hours after intervention. Semax were injected intraperitoneally at a dose of 150 mg / kg after 15 minutes and after 2 hours 15 minutes after ligation of coronary artery. The necrosis was formed in the anterior wall area both under irreversible ischemia and ischemia-reperfusion. Substantial morphological changes also developed in areas of relatively intact myocardium. These signs are accompanied by a significant increase of apoptotic index. Semax had no effects on the morphology of myocardium, but significantly reduced apoptosis of cardiomyocytes.
THE ANALYSIS OF PERSONNEL SAFETY IN PHARMACY
Authors: Kuznetsov Dmitriy Anatol'evich , Kuznetsov D A
Published: October 2016

In this article considers personnel safety, as a component of pharmaceutical economic safety. On the basis of a principle subsidiarity the concept of personnel safety and a matrix of support of personnel safety of the pharmaceutical organization is offered. With usage of the theory of fuzzy sets the system of a quantitative estimation of personnel making economic safety of the pharmaceutical organization is formulated. In operation major factors of personnel safety are studied, significances of weight coefficients are installed.
AUTOIMMUNE MECHANISMS IN THE PATHOGENESIS OF THE PRIMARY OPEN ANGLE GLAUCOMA (The literature review)
Authors: Sokolov Vladimir Anatol'evich , Mkkhinini Naufel' , Levanova Ol'ga Nikolaevna , Sokolov V A , Mkhinini N , Levanova O N
Published: October 2016

Numerous researches testify to presence of autoimmune aggression in pathogenesis POAG. Antibodies to various fabric components of an eyeball, both in forward, and in a back piece of an eye are found out. There are qualitative changes in collagenic structure of a sclera. There are products of pathological synthesis of the collagenic fibers having diagnostic, toxic, prognostic value. Change of a spectrum of immunoglobulins, cellular structure of
immunocompetent cells testify that are involved in pathogenesis POAG not only autoimmune mechanisms of an autoaggression, but also change of natural immunity, and weakening of regulating functions.
THE QUALITY OF LIFE OF PATIENTS WITH MENTAL DISORDERS
Authors: Filimonov Aleksandr Pavlovich , Volodin Boris Yur'evich , Filimonov A P , Volodin B Y
Published: October 2016

Now the conception of Quality of Life is used in medicine very often, and in psychiatry in particular. Many investigations show that the mental disorders lead to strong disturbance of different features of Quality of Life. The psychiatric symptoms, sex, self-esteem, the duration of the disease, the risk of loosing job, social stigma and social isolation have a great influence on Quality of Life of psychiatric patients. This information may be used for planning psychiatric service and also for the assessment of this service's results.
STUDY OF EXPRESSION P16INK4A, KI-67, VEGF AND E-CADHERIN SQUAMOUS INTRAEPITHELIAL LESIONS OF CERVIX
Authors: Shamarakova Marina Viktorovna , Shamarakova M V
Published: October 2016

The article presents the results of a study of the functional state of squamous intraepithelial lesions of the cervix, using modern molecular biology techniques, the selection of biomarkers to facilitate the diagnosis of epithelial proliferative changes, and determine the flow of precancerous cervical conditions. The study showed that lesions with structural features of CIN2 have different malignant potential and therefore the morphological criteria of a pathological process does not reflect the nature of the biological process.
MORPHOFUNCTIONAL CHARACTERISTICS TESTES WISTAR RATS EXPOSED TO LPS IN GIPERANDROGENEMII
Authors: Vasil'eva Svetlana Gennad'evna , Mkhitarov V A , Kosyreva A M , Makarova O V , Vassilievа S G , Mkhitarov V A , Kosyrevа A M , Makarovа O V
Published: October 2016

We investigated the morphological changes of the testes of Wistar rats with acute gram-negative ENDOTOXICOSIS against giperandrogenemii. In acute ENDOTOXICOSIS 1 st day after injection of lipopolysaccharide (LPS) showed a reduction in the level of total testosterone in serum, increase of Leydig cell nuclei and the diameters of the convoluted tubules, on the 7 th day, these figures were normalized. The introduction of LPS against giperandrogenemii recorded the most pronounced morphological changes, including significant reduction in the index of spermatogenesis, which reflects the suppression of spermatogenic function.
Dispensary management of patients with venous thromboembolic complications
Authors: Kalinin R E , Suchkov I A , Narizhniy M V
Published: October 2016

This article represents the results of dispensary managent of patients with venous thromboembolic complications. All the patients were admitted to the dispensary after discharge from vascular surgery department. Deep venous thrombosis group included 101 patients who underwent conservative treatment, 90 patients who received both conservative treatment and implantation of permanent vena cava filter «Corona», and 74 patients who underwent resection of a main deep vein. 28% patients had anamnestic pulmonary thromboembolism (PTE). Only 3.9% patients who underwent conservative threatment without surgical prophylaxis of PTE had recurrent thromboembolism of pulmonary artery during the period of dispensary management. Comparative analysis revealed a 2-times higher incidence of deep venous thrombosis in contralateral extremity after surgical methods of prophylaxis. According to the research results, dynamic observation of patients as well as timely control and correction of therapy allowed to significantly improve the efficacy of treatment and reduce the number of complications. Efficient programs of treatment and rehabilitation developed individually for each patient with venous thromboembolic complications allow for the effective treatment of thrombosis, impediment of the recurrence, and improvement of patient’s quality of life.
The study of carbohydrate and amino acid composition of Otites parviflorus herb
Authors: Erofeeva N S , Darmogray V N , Fursa N S
Published: October 2016

The carbohydrate and amino acid composition of Otites parviflorus herb was determined.
Morphological answer the gastric mucosa on contamination of different vital forms of pyloric helicobacter
Authors: Leonteva N I , Shcherbakov I T , Gracheva N M , Khrennikov B N , Shcherbakova E G , Partinthe O S
Published: October 2016

Нistopathological and gistobakteriological methods studied 178 biopsies of mucosa antrum and fundus of the stomach, obtained from 100 patients with «chronic gastroduodenitis». It was established that various vital forms of pyloric helicobacter (twisted, rod-and coccus) cause one type of chronic helicobacter gastritis, but different activity of the pathological process.
Characteristic of p-glycoprotein as a drug peptide transporter
Authors: Yakusheva E N , Chernykh I V , Biruicova A S
Published: October 2016

Review characterizes the urgency of problem, chemical properties of P-glycoprotein substrates, structure, functions, localization of peptide transporter, factors influencing P-glycoprotein activity.
Syndrome of dyspepsia and changes in gastroduodenal mucosa in the patients with acute viral hepatitises A and B
Authors: Karaseva E A , Martinov V A , Klochkov I N , Nikiforov A A
Published: October 2016

Syndrome of dyspepsia, mucosa of the gastroduodenal area based on the grounds of fibroezofagogastroduodenoscopy, Helicobacter pylori infection have been studied in the patients with acute viral hepatitises A and B. 122 patients with AVHA and AHVB have been investigated. Dyspepsia both AVHA and AVHB has been diagnosed with the same frequancy. Fibroezofagogastroduodenoscopy showed acute erosions and ulcers of gastroduodenal mucosa, or different forms of gastritis and gastroduodenitis. High frequency of Helicobacter pylori infection has been diagnosed in AVHA and AVHB which didn’t affect dyspeptic symptomatic and character of gastroduodenal mucosa lesions in investigated patients.
Serotoninergic structures strengthens vagal responses of the duodenum
Authors: Sveshnikov D S , Smirnov V M
Published: October 2016

The purpose of the study is to determine interaction between parasympathetic division of ANS and serotoninergic structures that regulate duodenal motility. Experiments were performed in 29 Chinchilla rabbits under general anesthesia, mechanical ventilation and bilateral vagotomy. Mechanical and electrical activity of the duodenum was recorded during electrical stimulation of the peripheral part of the right n.vagi in intact animals and after serotonin adipate injection. Found that serotonin enhances vagal effects of the duodenum increasing as power of reactions as their duration. Concluded that the serotoninergic structures, which control duodenal motility, are able to interact to parasympathetic division of ANS.
Aging of the population of the Nizhniy Novgorod region as a part of demographic development of the Russian Federation of last decades
Authors: Pozdnyakova M A , Semisynov S О
Published: October 2016

In article the demographic characteristic of the elderly population of the Nizhniy Novgorod region in comparison with the data across the Russian Federation as a whole is presented. The basic tendencies of demographic processes are considered and their principal causes are designated.
Innovation technologies in sanatorium treatment of climacteric syndrome
Authors: Malygina E P , Sokolov A V
Published: October 2016

The results of the work are based on inspection and treatment of 120 women with climakteriс syndrome, who underwent treatment in Clinical sanatorium «Priokskie daly» OOO «Gazprom transgaz Moscow» during the period 2007-2010y. The research has shown that level of funkcional reserves of organism in menoapauzal period whose low, and application of a course of low-frequency complex-modulated bioresonant electrotherapy with using of devise «HiTop» raises efficiency of complex rehabilitation treatment. Thus most expressed improvement of clinic-functional condition is noted in the control group of patients.
Clinical manifestations of endocrine orbitopathy in patients with autoantibodies to tireoperoksidaze vehicles
Authors: Likhvantseva V G , Sviridenko N Y , Rudenko E A , Gontyurova O A , Vygodin V A
Published: October 2016

The authors conducted a comparative analysis of clinical manifestations of endocrine orbitopathy in patients with Graves disease, depending on whether the presence of antibodies to tireoperoksidaze and their absence. The paper presents direct evidence to show that the persistence of autoantibodies to tireoperoksidaze endocrine orbitopathy affecting clinical manifestations. The Group of patients living with antibodies to SLIP more expressed above proptosis, eyelid edema and oculomotor disorders. Clinical evidence substantiated mul′tispiral′ computed tomography.
The morphological analysis of age changes of an arterial wall
Authors: Efimov A A
Published: October 2016

Results of research of age changes of elastic properties of an arterial wall are presented. The area of an internal surface of the allocated aorta, perimeter of the allocated aorta, contractility factor and the area of fragments of the right and left carotids, humeral and femoral arteries taken in a complex from 126 corpses of persons male and female died at the age from 17 till 94 years old are analyzed. Age indicators of elastic properties of an arterial wall are allocated quantitative and informative from morphological positions. Use of methods of parametrical statistics and the correlation analysis has proved expediency of their application by working out of a technique of definition of biological age of the person.
Influence phytoecdysteroides on a condition of the psychological status sick of a psoriasis
Authors: Terentyev S Ju , Yermoshina N P
Published: October 2016

The analysis of influence of preparations phytoecdysteroides in complex treatment sick of a psoriasis on their psychological characteristics is presented. Thus there is a considerable improvement of a psycho-emotional condition of patients that proves to be true normalization of indicators of a psychodiagnostic complex «Status PSY».
Venous thromboembolic complications after high amputation for chronic critical ischemia
Authors: Schwalbe P G , Baranov S V
Published: October 2016

Analyzed the frequency of venous thromboembolism after high amputation for chronic critical limb ischemia. It is shown that ultrasonography of deep veins have to be performed in all patients who had undergone high amputation for chronic critical limb ischemia, irrespective of the presence or absence of edema of the stump for the diagnosis of asymptomatic thrombosis in the postoperative period. Routine prophylaxis of thromboembolic complications allows 2-fold lower their rates after amputation of the thigh.
Clinical condition and quality of life sick of a psoriasis, as criteria of efficiency phytoecdysteroides in complex therapy of a dermatosis
Authors: Terentyev S Ju , Yermoshina N P , Darmograj V N
Published: October 2016

The analysis of influence of preparations phytoecdysteroides in complex treatment sick of a psoriasis on their clinical condition and quality of life is presented. Thus there is an expressed decrease in a psoriasis area and severity index and a dermatological index of a scale of symptoms, and also substantial increase of life quality of patients.
Immunological indices in patients with colorectal cancer during in-patient treatment
Authors: Semionkin E I , Bublikov I D
Published: October 2016

In the investigation immunological status assessment was made in patients with colorectal cancer of the III stage before and after operation. Cellular and humoral immunity was investigated, and psychovegetative status. We revealed immunosuppression in patients, they are in serious stress situation with prevalence of sympathetic regulation of peripheral nervous system.
Great scientist and the genius of medical sciences: the 130-anniver-sary of the death of N.I. Pirogov
Authors: Mnikhovich M V , Kaktursky L V , Huminski Y I , Fominа L V , Vernigorodsky S V , Kaminska N A , Miglyas V G
Published: October 2016

In an article on the 130th anniversary of the death of N.I. Pirogov, analysis of works N.I. Pirogov, which formed the foundation for the development of the modern fields of medicine. Works N.I. Pirogov covered a broad range of issues critical surgery, clinical, theoretical and experimental medicine, anatomy, general pathology, pathological anatomy, such as clinical and biological analysis of inflammation, abscesses, bone disease, infectious diseases and their control. Much attention N.I. Pirogov gave experimental studies on the development of collateral circulation, pathology of wound healing, shock, on plastic surgery. N.I. Pirogov – the creator of topographic (surgical) anatomy, pathology, policy makers, scientist, thinker and teacher.