bluuebunny/crossref_metadata_2025 huggingface dataset:
A Clinical Decision Support System for Remote Monitoring of Cardiovascular Disease Patients: A Clinical Study Protocol
Authors: Ventura Filipa , Sousa Pedro , Dixe Maria Anjos , Ferreira Paulo , Martinho Ricardo , Dias Sara Simões , Morais João , Gonçalves Lino M.
Published: May 2022

Introduction

Cardiovascular diseases (CVD) are the leading cause of death globally, taking an estimated 17. 9 million lives each year. Cardiac rehabilitation is shown to reduce mortality and hospital readmissions, while improving physical fitness and quality of life. Despite the recommendations and proven benefits, acceptance and adherence remain low. Mobile health (mHealth) solutions may contribute to more personalized and tailored patient recommendations according to their specific needs. This study protocol aims to assess the effectiveness of a user-friendly, comprehensive Clinical Decision Support System (CDSS) for remote patient monitoring of CVD patients, primarily on the reduction of recurrent cardiovascular events.

Methods and Analysis

The study will follow a multicenter randomized controlled design involving two cardiology units in the Center Region of Portugal. Prospective CVD patients will be approached by the healthcare staff at each unit and checked for eligibility according to the predefined inclusion/exclusion criteria. The CDSS will suggest a monitoring plan for the patient, will advise the mHealth tools (apps and wearables) adapted to patient needs, and will collect data. The clinical study will start in January 2023.

Discussion

The success of the mHeart.4U intervention will be a step toward the use of technological interfaces as an integrating part of CR programs.

Ethics and Dissemination

The study will undergo ethical revision by the Ethics Board of the two hospital units where the study will unfold. The study was registered in ClinicalTrials.gov on 18th January 2022 with the number NCT05196802. The study findings will be published in international peer-reviewed scientific journals and encounters and in a user-friendly manner to the society.
Magnitude and Determinant Factors of Postpartum Depression Among Mothers Attending Their Postnatal and Vaccination Services at Public Health Institutions of Addis Ababa, Ethiopia
Authors: Wake Getu Engida , Fitie Girma Wogie , Ashenafi Betelhem , Tadese Mesfin , Tessema Saba Desta
Published: May 2022

Background

The postpartum period is known as a high-risk period for the onset of different maternal mental health problems. Globally, 10–20% of postnatal mothers suffer from depressive symptoms. This study aimed to assess the magnitude and determinant factors of postpartum depression among mothers attending their postnatal and vaccination services at public health institutions in Addis Ababa, Ethiopia.

Methodology

Health institution-based cross-sectional study was conducted among 461 postnatal mothers attending public health institutions in Addis Ababa from 15 May 2021 to 15 July 2021. A multistage sampling technique was employed to select the public health institutions and a systematic random sampling method was used to get selected, postnatal mothers. Epidata version 3.1 and SPSS version 25 were used for data entry and analysis, respectively. P-value ≤ 0.05 was used as a cut point of statistical significance in multivariable binary logistic regression.

Results

From total postnatal mothers 91(19.7%) of them had postpartum depression. Occupational status [AOR = 3.39, 95% CI: 1.04, 8.15], marital status [AOR = 2.69, 95% CI =1.33, 5.45], income management [AOR = 3.76, 95% CI: 1.53, 8.21], sex of baby [AOR = 5.07, 95% CI: 1.24, 20.69], history of child death [AOR = 6.93, 95% CI: 2.67, 15.79], unplanned pregnancy [AOR = 3.08, 95% CI: 1.65, 7.93], negative life event [AOR = 2.39, 95% CI: 1.03, 5.39], substance use during pregnancy [AOR = 6.23, 95% CI: 2.72, 20.05], history of depression [AOR = 5.08, 95% CI: 1.79, 14.39], and marriage satisfaction [AOR = 6.37, 95% CI: 2.63, 14.29] were determinant factors of postpartum depression.

Conclusion

The prevalence of postpartum depression in this study is high compared to national findings. Occupational status, marital status, income management, sex of baby, history of child death, unplanned pregnancy, negative life event, substance use during pregnancy, history of depression, and marital satisfaction were determinant factors of postpartum depression. The ministry of health should integrate mental health services with existing maternal health care services. It would be better if all healthcare professionals working in the maternal and child health unit will routinely screen postpartum depressive symptoms and link them to mental health services.
Study on the Economic Burden of Neurodevelopmental Diseases on Patients With Genetic Diagnosis
Authors: Xie Donghua , Duan Ruoyu , Li Chen , Xie Zhiqun , Wang Aihua , Xiong Lili , Wei Jianhui , Xi Hui , Fang Junqu , Yan Huifang , Wang Junyu , Zhang Yu , Mao Xiao , Wang Jingmin , Wang Hua
Published: May 2022

Objective

To study the burden of neurodevelopmental diseases (NDDs) via cost-of-illness analysis of Chinese patients with genetic diagnosis.

Methods

We recruited NDD patients (0–18 years old) with genetic diagnosis (GD) from September 1, 2020 to January 30, 2021. We gathered basic information on the details of diagnosis, as well as the direct medical cost, direct non-healthcare cost and indirect cost before and after receiving GD. We corrected the cost for time biases by calculating the cost per day for each patient.

Results

For the 502 patients with NDDs, the mean age was 4.08 ± 3.47. The household income was 0.6 (0.4, 1.0) 10,000 CNY per-month on average. The direct medical cost, direct non-healthcare cost and indirect cost were 12.27 (7.36, 22.23) 10,000 CNY, 1.45 (0.73, 2.69)10,000 CNY and 14.14(4.80, 28.25) 10,000 CNY per patient, respectively. Every patient received 1.20 (0.34, 3.60) 10,000 CNY on average (15.91%) from insurance. The daily total cost after receiving GD were ~62.48% lower than those before GD (191.59 CNY vs. 71.45 CNY). The descend range of lab cost (95.77%, P < 0.05) was the largest, followed by drugs (91.39%, P < 0.05), hospitalization (90.85%, P < 0.05), and consultation (57.41%, P < 0.05). The cost of rehabilitation kept slightly increasing but there were no significant differences (P > 0.05). The daily direct medical cost of each patient fell by 75.26% (P < 0.05) from 311.79 CNY to 77.14 CNY when the diagnostic age was younger than 1, and declined by 49.30% (P < 0.05) and 8.97% (P > 0.05) when the diagnostic age was 1–3 and older than 3, respectively.

Conclusions

Early genetic diagnosis is crucial for to reducing the burden of disease because of the amount of money spent was lower when they are diagnosed at younger age. Patients with NDDs can incur a heavy economic burden, especially in rehabilitation cost and indirect cost, because the insurance coverage for patients is low, so it is urgent for governments to pay more attention to these issues.
Combination of Preoperative Multimodal Image Fusion and Intraoperative Dyna CT in Percutaneous Balloon Compression of Trigeminal Ganglion for Primary Trigeminal Neuralgia: Experience in 24 Patients
Authors: Liao Chang-chun , Li Jia-yan , Wu Kai-hua , Jian Zhi-heng , YI Xin-feng , Weng Zhi-jian , Chen Gang
Published: May 2022

Objective

We retrospectively assessed the surgical results of PBC with preoperative multimodal image fusion and intraoperative Dyna Computed Tomography (CT) in 24 patients with primary trigeminal neuralgia (PTN) to explore a valuable aid for Percutaneous balloon compression (PBC).

Methods

We studied the data of 24 patients with PTN. All patients underwent PBC and were assessed with preoperative multimodal image fusion [computed tomography (CT) and magnetic resonance imaging (MRI)] and intraoperative Dyna CT in the Department of Neurosurgery of Zhuhai People’s Hospital between October 2020 and September 2021. Multimodal image fusion—three-dimensional (3D) reconstruction of CT and MRI data—was performed using 3D-Slicer software, and preoperative evaluation was performed according to the results of image fusion. Dyna CT was used to dynamically observe the position and shape of the metallic hollow introducer and Fogarty catheter and balloon during the operation to guide the operation in real time. We performed follow-up assessments each month and summarized the clinical characteristics, surgical effects, and complications in all patients.

Results

Surgery was successful for all patients; the patients reported immediate pain relief. Surgical complications included facial numbness in 24 patients (100%), mild masseter weakness in three (12.5%), herpes zoster in three (12.5%), and balloon rupture in one (4.2%). None of the patients had serious surgical complications. The mean follow-up time was 9.6 ± 2.7 months. During the follow-up period, 22 patients (91.7%) experienced no recurrence of pain, and two patients (8.3%) experienced recurrence of pain, of which one underwent secondary PBC surgery.

Conclusions

Preoperative multimodal image reconstruction can help fully evaluate PBC surgery, clarify the etiology, and predict the volume of contrast medium required during the operation. It provided important assistance for PBC treatment of trigeminal neuralgia patients when preoperative multimodal image fusion is combined with intraoperative Dyna CT.
Comparative Toxicotranscriptomics of Single Cell RNA-Seq and Conventional RNA-Seq in TCDD-Exposed Testicular Tissue
Authors: Haimbaugh Alex , Meyer Danielle , Akemann Camille , Gurdziel Katherine , Baker Tracie R.
Published: May 2022

In this report, we compare the outcomes and limitations of two methods of transcriptomic inquiry on adult zebrafish testes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during sexual differentiation: conventional or bulk RNA-seq (bulk-seq) and single cell RNA sequencing (scRNA-seq) data. scRNA-seq has emerged as a valuable tool for uncovering cell type-specific transcriptome dynamics which exist in heterogeneous tissue. Our lab previously showed the toxicological value of the scRNA-seq pipeline to characterize the sequelae of TCDD exposure in testes, demonstrating that loss of spermatids and spermatozoa, but not other cell types, contributed to the pathology of infertility in adult male zebrafish exposed during sexual differentiation. To investigate the potential for technical artifacts in scRNA-seq such as cell dissociation effects and reduced transcriptome coverage, we compared bulk-sequenced and scRNA-seq-paired samples from control and TCDD-exposed samples to understand what is gained and lost in scRNA-seq vs bulk-seq, both transcriptomically and toxicologically. We hypothesized that the testes may be sensitive to tissue disruption as they contain multiple cell types under constant division and/or maturation, and that TCDD exposure may mediate the extent of sensitivity. Thus, we sought to understand the extent to which this dissociation impacts the toxicological value of data returned from scRNA-seq. We confirm that the required dissociation of individual cells from intact tissue has a significant impact on gene expression, affecting gene pathways with the potential to confound toxicogenomics studies on exposures if findings are not well-controlled and well-situated in context. Additionally, a common scRNA-seq method using cDNA amplified from the 3’ end of mRNA under-detects low-expressing transcripts including transcription factors. We confirm this, and show TCDD-related genes may be overlooked by scRNA-seq, however, this under-detection effect is not mediated by TCDD exposure. Even so, scRNA-seq generally extracted toxicologically relevant information better than the bulk-seq method in the present study. This report aims to inform future experimental design for transcriptomic investigation in the growing field of toxicogenomics by demonstrating the differential information extracted from sequencing cells—despite being from the same tissue and exposure scheme—is influenced by the specific protocol used, with implications for the interpretation of exposure-induced risk.
Application of Dual Frequency Comb Method as an Approach to Improve the Performance of Multi-Frequency Simultaneous Radiation Doppler Radar for High Temperature Plasma Diagnostics
Authors: Tokuzawa Tokihiko , Inagaki Shigeru , Inomoto Michiaki , Ejiri Akira , Nasu Tatsuhiro , Tsujimura Toru Ii , Ida Katsumi
Published: May 2022

A new Doppler radar using millimeter-waves in the Ka-band, named the “dual-comb Doppler reflectometer”, has been developed to measure the turbulence intensity and its velocity in high-temperature plasmas. For the realization of a fusion power generation, it is very important to know the spatial structure of turbulence, which is the cause of plasma confinement degradation. As a non-invasive and high spatial resolution measurement method for this purpose, we apply a multi-frequency Doppler radar especially with simultaneous multi-point measurement using a frequency comb. The newly developed method of synchronizing two frequency combs allows a lower intermediate frequency (IF) than the previously developed frequency comb radar, lowering the bandwidth of the data acquisition system and enabling low-cost, long-duration plasma measurements. In the current dual-comb radar system, IF bandwidth is less than 0.5 GHz; it used to be 8 GHz for the entire Ka-band probing. We applied this system to the high-temperature plasma experimental device, the Large Helical Device (LHD), and, to demonstrate this system, verified that it shows time variation similar to that of the existing Doppler radar measurements.
Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells)
Authors: Lapuente Juan Pedro , Gómez Gonzalo , Marco-Brualla Joaquín , Fernández Pablo , Desportes Paula , Sanz Jara , García-Gil Mario , Bermejo Fernando , San Martín Juan Víctor , Algaba Alicia , De Gregorio Juan Carlos , Lapuente Daniel , De Gregorio Almudena , Lapuente Belén , Gómez Sergio , Andrés María de las Viñas , Anel Alberto
Published: May 2022

Our research group has been developing a series of biological drugs produced by coculture techniques with M2-polarized macrophages with different primary tissue cells and/or mesenchymal stromal cells (MSC), generally from fat, to produce anti-inflammatory and anti-fibrotic effects, avoiding the overexpression of pro-inflammatory cytokines by the innate immune system at a given time. One of these products is the drug PRS CK STORM, a medium conditioned by allogenic M2-polarized macrophages, from coculture, with those macrophages M2 with MSC from fat, whose composition, in vitro safety, and efficacy we studied. In the present work, we publish the results obtained in terms of safety (pharmacodynamics and pharmacokinetics) and efficacy of the intravenous application of this biological drug in a murine model of cytokine storm associated with severe infectious processes, including those associated with COVID-19. The results demonstrate the safety and high efficacy of PRS CK STORM as an intravenous drug to prevent and treat the cytokine storm associated with infectious processes, including COVID-19.
The Association between Trajectories of Loneliness and Physical Frailty in Chinese Older Adults: Does Age Matter?
Authors: Sha Sha , Chan Sunny , Chen Lin , Xu Yuebin , Pan Yao
Published: May 2022

Background: The present study aimed to examine age differences in the relationship between trajectories of loneliness and physical frailty among Chinese older adults. Methods: A total of 4618 participants aged ≥60 years old were taken from pooled data created from the 2011–2015 China Health and Retirement Longitudinal Study (CHARLS). Loneliness was assessed by a single question from the Centre for Epidemiological Studies scale, whereas physical frailty (PF) was examined by the physical frailty phenotype scale. We characterized trajectories of loneliness and PF using transition types and changes within the survey period. Results: Logistic regression models revealed that baseline loneliness was significantly related to remaining robust PF (OR = 0.55, 95% CI = 0.49–0.63, p < 0.001) and worsening in PF (OR = 1.17, 95% CI = 1.05–1.30, p < 0.01) at follow-up. Baseline PF status was also significantly related to the transitions in loneliness (worsen: OR = 1.41, 95% CI = 1.11–1.78, p < 0.01; improve: OR = 0.65, 95% CI = 0.47–0.91, p < 0.05). The cross-lagged panel model found that baseline PF or loneliness had a significant predictive effect on the changes in each other. The associations between trajectories of loneliness and PF were weakened with age and clustered in the under 75 age groups. Conclusions: Bidirectional associations may exist between trajectories of loneliness and PF among Chinese older adults. Interventions should mainly target the young-old to reduce the adverse reciprocal effects of loneliness and PF.
Cholera Outbreaks in India, 2011–2020: A Systematic Review
Authors: Muzembo Basilua Andre , Kitahara Kei , Debnath Anusuya , Ohno Ayumu , Okamoto Keinosuke , Miyoshi Shin-Ichi
Published: May 2022

Fecal contamination of water sources and open defecation have been linked to cholera outbreaks in India. However, a systematic review on the drivers responsible for these outbreaks has yet to be published. Here, we systematically review the published literature on cholera outbreaks in India between 2011 and 2020. We searched studies in English in three databases (MEDLINE, EMBASE, and Web of Science) and the Integrated Disease Surveillance Program that tracks cholera outbreaks throughout India. Two authors independently extracted data and assessed the quality of the included studies. Quantitative data on the modes of transmission reviewed in this study were assessed for any change over time between 2011–2015 and 2016–2020. Our search retrieved 10823 records initially, out of which 81 full-text studies were assessed for eligibility. Among these 81 studies, 20 were eligible for inclusion in this review. There were 565 reported outbreaks between 2011 and 2020 that led to 45,759 cases and 263 deaths. Outbreaks occurred throughout the year; however, they exploded with monsoons (June through September). In Tamil Nadu, a typical peak of cholera outbreaks was observed from December to January. Seventy-two percent (33,089/45,759) of outbreak-related cases were reported in five states, namely Maharashtra, West Bengal, Punjab, Karnataka, and Madhya Pradesh. Analysis of these outbreaks highlighted the main drivers of cholera including contaminated drinking water and food, inadequate sanitation and hygiene (including open defecation), and direct contact between households. The comparison between 2011–2015 and 2016–2020 showed a decreasing trend in the outbreaks that arose due to damaged water pipelines. Many Indians still struggle with open defecation, sanitation, and clean water access. These issues should be addressed critically. In addition, it is essential to interrupt cholera short-cycle transmission (mediated by households, stored drinking water and foodstuffs) during an outbreak. As cholera is associated with deprivation, socio-economic development is the only long-term solution.
Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
Authors: Biezma María , Muñoz Patricia , De la Villa Sofía , Fariñas-Álvarez Mª , Arnáiz de las Revillas Francisco , Gutierrez-Carretero Encarnación , De Alarcón Arístides , Rodríguez-García Raquel , Llopis Jaume , Goenaga Miguel , Gutierrez-Villanueva Andrea , Plata Antonio , Vidal Laura , Martínez-Sellés Manuel ,   on behalf of GAMES
Published: May 2022

Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008–2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16–1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21–1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06–1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26–2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.
The Entomopathogenic Fungus Beauveria bassiana Shows Its Toxic Side within Insects: Expression of Genes Encoding Secondary Metabolites during Pathogenesis
Authors: Pedrini Nicolás
Published: May 2022

Entomopathogenic fungi are extensively used for the control of insect pests worldwide. Among them, Beauveria bassiana (Ascomycota: Hypocreales) produce a plethora of toxic secondary metabolites that either facilitate fungal invasion or act as immunosuppressive compounds. These toxins have different chemical natures, such as nonribosomal peptides and polyketides. Even though their precise role is poorly understood, they are usually linked to virulence. These fungal secondary metabolites are produced by the expression of gene clusters encoding the various proteins needed for their biosynthesis. Each cluster includes synthetases for nonribosomal peptides (NRPS), polyketides (PKS), or hybrid NRPS–PKS genes. The aim of this review is to summarize the information available from transcriptomics and quantitative PCR studies related to the expression of B. bassiana NRPS and PKS genes inside different insects as the infection progresses; as for the host immune response, to help understand the mechanisms that these toxins trigger as virulence factors, antimicrobials, or immunosuppressives within the context of a fungus–insect interaction.
Diversity, Abundance, and Ecological Roles of Planktonic Fungi in Marine Environments
Authors: Sen Kalyani , Sen Biswarup , Wang Guangyi
Published: May 2022

Fungi are considered terrestrial and oceans are a “fungal desert”. However, with the considerable progress made over past decades, fungi have emerged as morphologically, phylogenetically, and functionally diverse components of the marine water column. Although their communities are influenced by a plethora of environmental factors, the most influential include salinity, temperature, nutrients, and dissolved oxygen, suggesting that fungi respond to local environmental gradients. The biomass carbon of planktonic fungi exhibits spatiotemporal dynamics and can reach up to 1 μg CL−1 of seawater, rivaling bacteria on some occasions, which suggests their active and important role in the water column. In the nutrient-rich coastal water column, there is increasing evidence for their contribution to biogeochemical cycling and food web dynamics on account of their saprotrophic, parasitic, hyper-parasitic, and pathogenic attributes. Conversely, relatively little is known about their function in the open-ocean water column. Interestingly, methodological advances in sequencing and omics approach, the standardization of sequence data analysis tools, and integration of data through network analyses are enhancing our current understanding of the ecological roles of these multifarious and enigmatic members of the marine water column. This review summarizes the current knowledge of the diversity and abundance of planktonic fungi in the world’s oceans and provides an integrated and holistic view of their ecological roles.
Patterns of Recurrent Disease in Cervical Cancer
Authors: Miccò Maura , Lupinelli Michela , Mangialardi Matteo , Gui Benedetta , Manfredi Riccardo
Published: May 2022

Uterine cervical cancer is one of the most common causes of cancer-related deaths among women worldwide. Patients with cervical cancer are at a high risk of pelvic recurrence or distant metastases within the first few years after primary treatment. However, no definitive agreement exists on the best post-treatment surveillance in these patients. Imaging may represent an accurate method of detecting relapse early, right when salvage treatment could be effective. In patients with recurrent cervical cancer, the correct interpretation of imaging may support the surgeon in the proper selection of patients prior to surgery to assess the feasibility of radical surgical procedure, or may help the clinician plan the most adaptive curative therapy. MRI can accurately define the extension of local recurrence and adjacent organ invasion; CT and 18F-FDG PET/CT may depict extra-pelvic distant metastases. This review illustrates different patterns of recurrent cervical cancer and how imaging, especially MRI, accurately contributes towards the diagnosis of local recurrence and the assessment of the extent of disease in patients with previous cervical cancer. Normal post-therapy pelvic appearance and possible pitfalls related to tissue changes for prior treatments will be also illustrated.
Non-Pharmacological Nursing Interventions to Prevent Delirium in ICU Patients—An Umbrella Review with Implications for Evidence-Based Practice
Authors: Lange Sandra , Mędrzycka-Dąbrowska Wioletta , Friganovic Adriano , Oomen Ber , Krupa Sabina
Published: May 2022

Delirium in ICU patients is a complication associated with many adverse consequences. Given the high prevalence of this complication in critically ill patients, it is essential to develop and implement an effective management protocol to prevent delirium. Given that the cause of delirium is multifactorial, non-pharmacological multicomponent interventions are promising strategies for delirium prevention. (1) Background: To identify and evaluate published systematic review on non-pharmacological nursing interventions to prevent delirium in intensive care unit patients. (2) Methods: An umbrella review guided by the Joanna Briggs Institute was utilized. Data were obtained from PubMed, Scopus, EBSCO, Web of Science, Cochrane Library, and Google Scholar. The last search was conducted on 1 May 2022. (3) Results: Fourteen reviews met the inclusion criteria. Multicomponent interventions are the most promising methods in the fight against delirium. The patient’s family is an important part of the process and should be included in the delirium prevention scheme. Light therapy can improve the patient’s circadian rhythm and thus contribute to reducing the incidence of delirium. (4) Conclusions: Non-pharmacological nursing interventions may be effective in preventing and reducing the duration of delirium in ICU patients.
Modelling Seasonal Short-Run Effects in Time-Series Tourism Prices
Authors: Gricar Sergej , Bojnec Stefan
Published: May 2022

The paper’s primary purpose is to better monitor shocks; therefore, reliable scientific methods should be used to predict, monitor, and implement those events. In this paper, tourism prices are studied as an economic, I(2) and social phenomenon for better performance. The selection of inadequacies in price time series is analysed. The state-of-the-art proposed methodology step of nominal to real prices is based on monthly data using the cointegrated-vector-autoregressive model (CVAR). This is the key feature selection on time-series properties in the economy and supported software(s). An attempt at a CVAR model with five seasonally unadjusted macroeconomic variables is developed. It introduces a meaningful, genuine and indispensable new data vector of transformed variables, and this stepwise process is more appropriate against the wrong model specification. The results for the period of economic crises show that the proposed model is reliable from nominal to real prices, and the researchers implement normality to price modelling in its econometric mock-up phase. Overall, the proposed model predicts testable events for up to 48-months.
Attributes of Business Incubators: A Conjoint Analysis of Venture Capitalist’s Decision Making
Authors: Manconi Michele , Bellomo Salvatore , Nosella Anna , Agostini Lara
Published: May 2022

Startups contribute significantly to the economic development of a country. Despite their importance and promising future, they are extremely fragile, mainly for their lack of tangible and intangible resources. Since this can be obtained through an incubation process, business incubators (BIs) could have a significant impact on the survival rate of startups. Once defined their core structure and value proposition, there are other players, such as venture capitalists who could guarantee the funds necessary to make the startup’s business grow over time. Drawing on the resource-based view theory, this research explores whether some BIs could represent a certification of startup quality for venture capitalists (VCs). Specifically, we investigate whether some specific attributes of BIs increase the probability that a VC funds startups after being incubated; to this purpose, we carry out an experiment on a European sample of VCs. Results demonstrate that some characteristics of the BI can produce a sort of certification effect to the incubated startups, increasing the probability of being funded by VCs.
Impacts of Zagreb’s Urban Development on Dynamic Changes in Stream Landscapes from Mid-Twentieth Century
Authors: Gašparović Sanja , Sopina Ana , Zeneral Anton
Published: May 2022

Urban streams constitute a valuable form of multi-functional blue and green infrastructure (BGI) and can support urban development to generate ecosystem, social, and economic benefits. In global cities, planning for BGI enhancement contributes to climate change adaptation, ecosystem restoration, community health and wellbeing, improved quality of life, etc. This research aims to assess the dynamics of stream landscape change in Zagreb as well as the influence of urban development on the blue and green landscape and related urban values. The analysis of landscape features and their planning is conducted at the level of the stream system of the whole city of Zagreb and at the level of two stream sequences by superimposing spatial data from cartographic sources. By developing an urban planning-social-ecological approach to evaluation, monitoring, and management, a quantitative and qualitative trend in stream landscape changes is identified and indicators for detecting areas of critical urbanization pressure are established. This research confirms the trend of negative changes in the urban BGI, evident in the present state (interruption of open streams, and the reduction, fragmentation, and disconnection of blue and green landscape), as well as in the planned neglect (plans for further stream closures and reduction in public green areas). Stream landscape potential is emphasized as one of the greatest urban assets for improving the system of BGI, and areas needed for their prioritization in urban planning measures, directed towards an increase in multiple landscape values, are determined.
Land Attachment, Intergenerational Differences and Land Transfer: Evidence from Sichuan Province, China
Authors: Liu Guihua , Yang Liping , Guo Shili , Deng Xin , Song Jiahao , Xu Dingde
Published: May 2022

It is of great significance to explore the influencing factors of land flow to promote moderate-scale agricultural operation. However, few studies have explored the quantitative influences of land attachment and intergenerational difference on land transfer. Based on the survey data of 540 rural households in Sichuan Province, this study uses factor analysis method to divide land attachment into land satisfaction, land rootedness, and land dependence, and further empirically tests the impact mechanism of land attachment and intergenerational difference on land flow by using Probit model and Tobit model. The results are as follow: (1) land attachment is significantly correlated with land flow-out, but not with land flow-in. (2) Different dimensions of land attachment have different impacts on land flow-out. Among them, land rootedness and land dependence have significant negative impacts on farmers’ land flow-out behavior and land flow-out area, while land satisfaction has a significant positive impact on farmers’ land flow-out behavior and has no significant impact on the land flow-out area. (3) Different generations of land attachment have different impacts on land flow-out. Among them, the land attachment of the new-generation farmers has no significant impact on land flow-out. Among middle-aged farmers, land dependence had a significant negative impact on land flow-out behavior and area, and land rootedness had a significant negative impact on land flow-out behavior; however, land satisfaction had a significant positive impact on land flow-out behavior and area. Among the older generation of farmers, land dependence has a significant negative impact on land flow-out behavior and area, while land satisfaction and land rootedness have no significant impact on land flow-out behavior and area. Therefore, in promoting the practice of land flow, we should pay attention to the differences of farmers’ emotional demands, improve the supporting policies of land flow by classification, reduce farmers’ dependence on “land security”, solve farmers’ concerns on land flow, and promote the rational flow of land factors.
Torrential Hazard Prevention in Alpine Small Basin through Historical, Empirical and Geomorphological Cross Analysis in NW Italy
Authors: Turconi Laura , Tropeano Domenico , Savio Gabriele , Bono Barbara , De Sunil Kumar , Frasca Marco , Luino Fabio
Published: May 2022

Debris flow is one of the most dangerous natural processes in mountain regions and it occur in a wide variety of environments throughout the world. In the Italian Alps, some tens of thousands of damaging debris flow and, in general, torrential floods associated to intense sediment transport in secondary catchments have been documented in the last 300 years. These have caused socio-economic damage, damage to anthropogenic structures or infrastructures and in many cases casualties. Often, in the same basins, the occurrence of debris-flow processes recurs many years later. Prediction can often be spatial and based on the magnitude of the largest known process, while the temporal forecast is the most uncertain. It is also possible to increase the resilience of the population and of the territory. The present study aims at investigating different levels of debris-flow hazard in urban areas on Alpine alluvial fans and proposes a strategy for debris-flow prevention based on historical research and on a simplified analytical approach, methods that also involve relatively low costs. For such analysis, Ischiator stream catchment (ca. 20 km2) and its alluvial fan (NW Italy) were selected. This area was partly affected by historical torrential flood associated to intense sediment transport and debris-flow processes. Present-day instability conditions along the slope and the stream network were detected and synthesized through surveys and aerial photo interpretation integrated by satellite images (period 1954–2021). An estimation of the potential amount of moving detritus, referred to as debris flow, was carried out regarding the June 1957 debris-flow event, based on the predictive models. The individual hazard index value was estimated based on different methods. The results indicate that 56% of the area is exposed to flood associated to intense sediment transport hazard, which fluctuates from high to very high levels; such results are supported by debris-flow historical records. Since today almost half of the settlement (Bagni di Vinadio) is located on potentially risk-exposed areas, the urban evolution policy adopted after the 1957 event failed to manage the risk connection to debris-flow activity.
Fire Eaters: Exploring Consumer Preferences for Labeling Extensive Livestock Products Providing Wildfire Prevention Services
Authors: Soy-Massoni Emma , Uyttewaal Kathleen , Prat-Guitart Núria , Varela Elsa
Published: May 2022

Extensive livestock grazing has proved to be a valuable tool to reduce wildfire risk in Mediterranean landscapes. Meat from herds providing wildfire prevention services exhibit sustainability traits that can appeal to ethical consumers and find a suitable niche in local markets. This study assesses the preferences of a consumer sample in the province of Girona (north-eastern Spain) for different lamb meat labeling options from herds providing wildfire prevention services. The aim is to disentangle consumer profiles, providing evidence for improved product labeling. This may increase the added value and the viability of small farms providing this service. Employing a latent class modeling approach, we explore how meat consumption patterns and socioeconomic features may contribute to explain preferences for different meat labeling options. Our results have identified three consumer profiles: traditional rural consumers relying on trust with producers, younger consumers more akin to new labeling schemes, and urban consumers that support local butchers as a trusted information source. Different labeling mechanisms may work in a complementary way to arrive to different audiences of potential consumers. Geographical indication labels can serve as a good departure point, complemented with information cues on environmental factors related to wildfire protection.
Land-Use Classifying and Identification of the Production-Living-Ecological Space of Island Villages—A Case Study of Islands in the Western Sea Area of Guangdong Province
Authors: Bai Rui , Shi Ying , Pan Ying
Published: May 2022

Accurately identifying the rural production-living-ecological space (PLES) of different islands can help reveal their distinct natural resources and land-use situations, which is significant for the sorted management, subarea utilization, and protection of islands. At present, studies on the PLES of island villages are deficient. For instance, the existing land-use classification system is incomplete; the PLES is poorly identified; and the dominant function of multiple land-use types based on different island geomorphology types is insufficiently investigated. Therefore, a case study was conducted on the island villages of the western sea area of Guangdong Province, based on remote sensing, spatial analysis, and land classification, with field research and the relevant data. In this study, before establishing the PLES system, the islands were classified, including six bedrock islands, 10 sedimentary islands, and one volcanic island. When the PLES system of the island villages was classified, the ecological and utilized areas of the intertidal zone and neritic region should be combined with the island–continent part, and the distinct industrial types should be emphasized, before forming 22 secondary types of PLES. Furthermore, it is found that each island generally has its own dominant space and land-use type. Ecological space (ES) dominates the bedrock islands, and production space (PS) is prominent for sedimentary islands and volcanic islands. Forestland, aquaculture pond, and dryland are the prominent land-use types for bedrock islands, sedimentary islands, and volcanic islands, respectively. The rural residential lands are the main component of living space (LS) in all islands, and the most urban residential lands are distributed on the bedrock islands. The main driving factors for the formation and distribution of island rural PLES are the altitudinal gradient and geomorphic characteristics. The research shows that the main problems of PLES are that the intertidal zones are threatened by aquaculture ponds at various levels, and the development of LS in these islands is generally backward.
SARS-CoV-2 Infection and Taste Alteration: An Overview
Authors: Scotto Gaetano , Fazio Vincenzina , Lo Muzio Eleonora , Lo Muzio Lorenzo , Spirito Francesca
Published: May 2022

Since the worldwide spread of SARS-CoV-2 infection, the management of COVID-19 has been a challenge for healthcare professionals. Although the respiratory system has primarily been affected with symptoms ranging from mild pneumonia to acute respiratory distress syndrome, other organs or systems have also been targets of the virus. The mouth represents an important route of entry for SARS-CoV-2. Cells in the oral epithelium, taste buds, and minor and major salivary glands express cellular entry factors for the virus, such as ACE2, TMPRSS2 and Furin. This leads to symptoms such as deterioration of taste, salivary dysfunction, mucosal ulcers, before systemic manifestation of the disease. In this review we report and discuss the prevalence and socio-demographics of taste disturbances in COVID-19 patients, analysing the current international data. Importantly, we also take stock of the various hypothesized pathogenetic mechanisms and their impact on the reported symptoms. The literature indicated that COVID-19 patients frequently present with gustatory dysfunction, whose prevalence varies by country, age and sex. Furthermore, this dysfunction also has a variable duration in relation to the severity of the disease. The pathogenetic action is intricately linked to viral action which can be expressed in several ways. However, in many cases these are only hypotheses that need further confirmation.
Sodium-Glucose Co-Transporter 2 Inhibitors Reduce Macular Edema in Patients with Diabetes mellitus
Authors: Tatsumi Tomoaki , Oshitari Toshiyuki , Takatsuna Yoko , Ishibashi Ryoichi , Koshizaka Masaya , Shiko Yuki , Baba Takayuki , Yokote Koutaro , Yamamoto Shuichi
Published: May 2022

Purpose: To determine the efficacy of systemic sodium-glucose co-transporter 2 inhibitors (SGLT2i) on diabetic macular edema (DME). Methods: The medical records of patients with DME with a central retinal thickness (CRT) ≥320 µm in men and 305 µm in women, more than 6 months after the initiation of diabetes mellitus treatment, were reviewed. The CRT and best-corrected visual acuity (BCVA) were evaluated before and after the initiation of systemic SGLT2i and non-SGLT2i treatments. Results: There were 24 eyes of 19 patients with DME that were treatment naïve or had not received treatments for the DME within four months before the initiation of SGLT2i. In these patients, the BCVA had a 0.31 ± 0.39 logarithm of the minimum angle of resolution (logMAR) units at the baseline, and it did not improve significantly at 0.26 ± 0.29 logMAR units after the initiation of SGLT2i (p = 0.56). However, the SGLT2i treatment significantly reduced the CRT from 423.3 ± 79.8 µm to 379.6 ± 69.5 µm (p = 0.0001). In the same evaluation of 19 eyes of 14 patients with DME that were initiated with non-SGLT2i agents, there was no significant difference between the baseline BCVA and the BCVA after the initiation of non-SGLT2i (p = 0.47). The CRT increased significantly after the initiation of non-SGLT2i (p = 0.0011). In three eyes in which the SGLT2i treatments were administered at the time of anti-vascular endothelial growth factor (VEGF) treatments, the anti-VEGF treatment alone had only a limited effect on the DME, but the reduction in the DME was enhanced after the addition of SGLT2i. Conclusions: These findings indicate that systemic SGLT2i can reduce DMEs, and they suggest that SGLT2i may be an additional treatment option to anti-VEGF treatments for eyes with DMEs.
Green Coffee Bean Extract Normalize Obesity-Induced Alterations of Metabolic Parameters in Rats by Upregulating Adiponectin and GLUT4 Levels and Reducing RBP-4 and HOMA-IR
Authors: Seliem Esraa M. , Azab Mohamed E. , Ismail Randa S. , Nafeaa Abeer A. , Alotaibi Badriyah S. , Negm Walaa A.
Published: May 2022

Obesity is a serious public health issue worldwide. Finding safe and efficacious products to reverse obesity has proven to be a difficult challenge. This study showed the effects of Coffea arabica or green coffee bean extract (GCBE) on obesity disorders and the improvement of obesity-induced insulin resistance, dyslipidemia, and inflammation. The active constituents of GCBE were identified via high-performance liquid chromatography. Twenty-four male albino Wistar rats were divided into two groups. The first group (Group I) was fed a control diet, whereas the second group was fed a high-fat diet (HFD) for eight weeks till obesity induction. The second group was equally subdivided into Group II, which received HFD, and Group III, which received HFD + GCBE for another eight weeks. The body and organ weights of the animals were measured, and blood and adipose tissue samples were collected for analysis. The results indicated that the administration of GCBE significantly decreased the body and organ weights. Furthermore, it had an ameliorative effect on serum biochemical parameters. It dramatically reduced total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, glucose, and insulin levels. In addition, an improvement in homeostasis model assessment-insulin resistance and an enhancement of high-density lipoprotein cholesterol levels were observed compared with the HFD group. In addition, the group treated with GCBE exhibited a marked increase in serum levels of adiponectin (an anti-inflammatory adipokine). In addition, a considerable reduction in adipocyte hypertrophy was found following GCBE treatment. Remarkably, the administration of GCBE resulted in a remarkable decrease in the expression of RBP4 (a pro-inflammatory cytokine), whereas an increase in GLLUT4 expression was observed in the adipose tissue. This improved insulin resistance in GCBE-administered HFD rats compared with other HFD rats. Our study showed that GCBE exhibits anti-obesity activity and may be used as a natural supplement to prevent and treat obesity and its associated disorders.
Dextromethorphan Exhibits Anti-Inflammatory and Immunomodulatory Effects in a Murine Model: Therapeutic Implication in Psoriasis
Authors: Chen Yi-Ming , Chen I-Chieh , Chao Ya-Hsuan , Chen Hsin-Hua , Chen Po-Ku , Chang Shih-Hsin , Yeo Kai-Jieh , Wey Shiow-Jiuan , Lin Chi-Chien , Chen Der-Yuan
Published: May 2022

Psoriasis is an immune-mediated skin disease with a worldwide prevalence of 2–4% that causes scaling erythematous skin lesions. It is a chronic relapsing and complex multifactorial disease that often necessitates long-term therapy. Despite various novel therapies, psoriasis remains a treatable but non-curable disease. Because the antitussive medication dextromethorphan (DXM) can inhibit murine bone marrow and human monocytes and slow the progression of arthritis in mice with type II collagen-induced arthritis, we explored whether the oral administration of DXM to mice with imiquimod (IMQ)-induced psoriasis can effectively alleviate psoriasis symptoms and improve immune regulation. Herein, we examined the therapeutic effects of DXM on psoriasis and its potential mechanisms of action in an IMQ-induced psoriasis mice model. We found that an oral dose of DXM (10 mg/kg) could more significantly reduce psoriasis symptoms compared with intraperitoneal injection. Seven days after the oral administration of DXM, the Psoriasis Area and Severity Index (PASI) score was significantly decreased compared with that in the vehicle group. Furthermore, DXM treatment also significantly ameliorated the psoriasis symptoms and the histopathological features of psoriasis, including stratum corneum thickening, desquamation, and immune cell infiltration. Additionally, DXM reduced the mRNA levels of the cytokines TNF-α, IL-6, IL-17A, and IL-22 in skin and the percentage of IL-17A and IL-22 producing T cell receptor γδ T cells (TCRγδT). Taken together, our research demonstrated that DXM could inhibit keratinocyte proliferation and alleviate psoriasis symptoms, which suggests the potential application of DXM in the treatment of chronic inflammation and autoimmune diseases.