bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EVALUATION OF ANTI-EPILEPTIC DRUGS DOSAGE IN MALNOURISHED CHILDREN: CASES IN INDONESIAN COMMUNITY OF EPILEPSY
Authors: Endriastuti Nialiana Endah , Suryoputri Masita Wulandari , Ilma Dewi Latifatul
Published: August 2022

Anti-epileptic drug (AED) has a narrow therapeutic index of drugs that a slight increase in dosage showed toxic effects. The therapeutic response is difficult to predict in malnutrition status because the patient with nutritional deficiency have more complicated problems likes hypoalbuminemia, macronutrient and micronutrients deficiency that affected the levels of AEDs. The nutritional deficiency could be a direct and indirect cause of ineffective AEDs therapy and also recurrent epilepsy. This study aims to describe the use of antiepileptic drugs in Indonesian children with poor nutritional status. The research design was observational studies with cross sectional random sampling to evaluate the AED doses of malnutrition status in children. All information was collected by spreading electronic forms and interviewing the parents by phone. The data were analyzed descriptively. Total of 8 malnourished children mostly included in the range of ages from >2 to 12 years (n=5; 62.50%) with means 3,9±2,7 years. The study showed valproic acid was bigger used in monotherapy (n=5; 62,50%) than polytherapy with carbamazepine or sodium phenytoin and phenobarbital. The means estimation of valproic acid monotherapy concentration in females’ group (n=2; 33,33%) showed sub-therapeutics level were Cssmin 26,09±0,57 mg/L and Cssmax 64,17±1,39 mg/L, also the means in males’ group (n=2; 33,33%) of valproic acid monotherapy were Cssmin   22.07±2,71 mg/L and Cssmax 54.27±6.66 mg/L. All of them included in good clinical outcome of free seizure > 6 months.
QUALITATIVE AND QUANTITATIVE ANALYSIS OF PARACETAMOL CONTAMINATION IN RHEUMATIC PAIN TRADITIONAL MEDICINE
Authors: Permatasari Desy Ayu Irma , Setyowati Rini , Mahardika Muladi Putra
Published: August 2022

Analgesic drugs are often added illegally in rheumatic pain traditional medicine. Paracetamol is one of chemical drugs that have a large possibillity to be added in rheumatic pain traditional medicine. The aims this research were to know paracetamol and concentration of paracetamol in rheumatic pain traditional medicine in Borobudur District. This research is experimental research, the analysis data were used microsoft excel and linear regression. Qualitative analysis method using organoleptic test to description the sample, TLC test to evaluation Rf value and FTIR test for characterization. Quantitative analysis method using LC-MS test to know the paracetamol concentration contained on the rheumatic pain traditional medicine. Organoleptic test the results show description the shape, color, smell and taste of sample A, B and C. The results of the TLC evaluation showed sample A and B were positive, indicated by a purple spot and the Rf value of the sample was exactly same compared to Rf value of standard paracetamol, while sample C is negative. The result of the FTIR spectra showed that sample A and B have same functional group as the standard paracetamol, while sample C showed none. LC-MS test results after calculating the concentration in samples A and C the concentration was obtained < 4,4 μg/kg below the Detection Limit (LoD): 4,4 μg/kg, while sample B the concentration was obtained 2,22%. Based on the results of all three samples tested, the sample A and sample B were positively contaminated by chemical medicine paracetamol while sample C were negative.
COST OF ILLNESS DIABETES MELITUS TIPE 2: NARRATIVE REVIEW
Authors: Pramasari Nadia , Endarti Dwi , Widayanti Anna Wahyuni
Published: August 2022

Diabetes mellitus (DM) is chronic disease that requires routine lifelong treatment. Uncontrolled blood sugar levels in DM patients can cause complications. This has an impact on the burden of health costs. The aim of this study to conduct a narrative review of the cost of illness in type 2 DM patients in various countries. The English articles used in this study were obtained from Pubmed, ScienceDirect, and Wiley that published in the period 2011 to 2021. The cost reported in the articles were local currency that later converted into US dollars according to the time of the study. Based on the narrative review, there are 19 articles that meet the criteria. In the article, there are varied perspectives, methods, and cost categories. The total cost per year for type 2 DM ranged from US$246.1 to US$5894.1, direct, and indirect costs per patient per year ranged from US$ 104.6 to US$5246.4 and US$82.9 to US$2299.4. Type 2 diabetes mellitus increases the burden of health costs. The presence of complications in type 2 DM patients requires higher health costs compared to uncomplicated type 2 DM patients and non-DM patient
THE INFLUENCES OF KNOWLEDGE LEVEL BEHAVIOUR AND ATTITUDE IN SELECTING TYPE OF POWDER ON THE INCIDENCE OF ACNE VULGARIS IN BANYUMAS REGENCY
Authors: Fauzana Anggita Nur , Hapsari Indri , Putri Irsalina Nurul , Galistiani Githa Fungie
Published: August 2022

Background: Acne vulgaris is a chronic obstructive and inflammatory skin disease. It occurs in almost all adolescents with a prevalence of 90%. Pathogenesis of Acne vulgaris is estimated to be related to several triggering factors such as food by 23.2%, stress by 26.4%, hormones by 32.7% and use of cosmetics by 47.3%. Powder is the most widely used cosmetic in the long term and one of the causes of Acne vulgaris which causes occlusion of pores on the skin surface. In the content of powder that causes acne vulgaris because there are comedogenic ingredients such as lanolin. Methods: This study was an observational study with data collection techniques using cluster sampling and sampling technique by accidental sampling. Results: The level of knowledge of women in the Banyumas Regency was dominated by the high category as many as 64 respondents (64.0%). The incidence of acne vulgaris out of 100 respondents, 67 (67.0%) of respondents had mild acne vulgaris, 22 respondents (22.0%) had moderate acne vulgaris and 1 respondent (1.0%) had severe acne vulgaris and the rest had no acne vulgaris. Chi-square analysis showed that there was a relationship between knowledge with behavior and attitude in choosing the type of powder to the incidence of acne vulgaris as evidenced by the p value of each variable, namely 0.044 and 0.028 (p <0.05). Conclusion: the level of knowledge with behavior and attitude in choosing the powder type had a significant relationship to the incidence of acne vulgaris in women in Banyumas Regency.
STABILITY AND SUNSCREEN ACTIVITY OF NUTMEG SEED OIL EMULGEL WITH CARBOPOL 940 VARIATION AS GEL BASE
Authors: Khafifa Ilma Nur , Shabrina Ayu , Rochman M Fatchur
Published: August 2022

Nutmeg seed oil is one of essential oil which unstable in storage. The stability of nutmeg seed oil can be improved by being formulated into an emulgel with carbopol 940. This study was to determine the physical stability and SPF value of nutmeg oil emulgel in vitro with carbopol 940 as a gel base. Nutmeg seed oil emulgel was made with 10% nutmeg seed oil concentration and variation of carbopol 940 base, namely 0.60% (FI), 0.80% (FII), and 1.0% (FIII). Nutmeg seed oil emulgel was tested for physical stability including organoleptic, homogeneity, adhesion, dispersibility, viscosity, pH, and SPF value in vitro. Evaluation of physical stability and SPF value of nutmeg oil emulgel was carried out for 30 days of storage at 30±2°C with RH 65±5%. Quantitative data from evaluation of physical stability and SPF value were analyzed by t-test dependent. All the physical parameters showed no significant changes (p > 0.05). Emulgel were white, thick, with nutmeg seed oil odor. pH were in safe range for skin (6.12-6.90). Nutmeg seed oil emulgel had pseudo plastic rheology in day 0 and it changed into pseudoplastic-tixothropic on day 30.  The SPF value of nutmeg seed oil emulgel FI, FII, and FIII were above 8 and it did not showed significant change after 30 days of storage (p > 0.05). The SPF value of nutmeg seed oil emulgel were categorized as maximum protection.
SOME NATURAL FLAVONOIDS FROM GUAVA (PSIDIUM GUAJAVA L.) AGAINST SARS COV-2, INSILICO PREDICTION AND DRUGS EVALUATION
Authors: Wardani Arief Kusuma
Published: August 2022

Important for an emergency is to find the most potential Hesperidin, Kaempferol-3,4'-di-O-methyl ether (Ermanin); Myricetin-3-glucoside, Peonidine 3-(4’-arabinosylglucoside); Quercetin 3-(2G-rhamnosylrutinoside); and Rhamnetin 3-mannosyl-(1–2)-alloside as a lead compound from guava to develop new drugs from flavonoid analogue. Docking method through iGEMDOCK software was used to design a new lead compound candidate from several flavonoid and study its interaction with of 3CLpro  (PDB ID: 7DPU). The docking method were carried out using the iGEMDOCK software version v2.1, also in the chimera-1.13.1 program is used to know the interaction profile. Druglike properties were calculated using Lipinski’s rule of five as calculated using SWISSADME prediction. Toxicity prediction herein used ADMETSAR webserver (http://lmmd.ecust.edu.cn:8000/predict/). Less toxic and showing greater affinity with a docking score stronger was found in Quercetin, is apart from good pharmacokinetic profile
EVALUATION OF RESPONSE CORELLATION USING CHEMOMETRICS ANALYSIS FOR PRE-OPTIMIZATION QUERCETIN – SELF EMULSION FORMULATION
Authors: Shiyan Shaum , Nathasia Jessica , Pratiwi Galih
Published: August 2022

The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the response from the optimization stage using the quercetin – self emulsion formulations (quercetin-SEFs) as a model. SEFs were prepared using grapeseed oil, croduret, and PEG 400. The evaluated responses included emulsification time and transmittance. Both responses were developed in endurance test by centrifugation method and stability test using freeze-thaw. Chemometric analysis on CA produced a dendrogram, while PCA produced score plots, loading plots, scree plots, and biplots. Emulsification time has a positive correlation with transmittance value. The quercetin-SEFs formula in SCD was classified into three groups based on the similarity of characters. Chemometric analysis was successfully applied in evaluating the response to the quercetin-SEFs optimization modeling.
Ernesto Bustamante Zuleta (1922–2021): pioneering teacher and practitioner of Colombian neurosurgery
Authors: Alvernia Jorge E. , Berbeo Calderón Miguel Enrique , Cespedes Jorge , Vargas John , Grady Matthew , Cadavid Luis C. , Fonseca Enrique Osorio , Posada Adolfo Cumplido
Published: August 2022

Ernesto Bustamante Zuleta (1922–2021) was an impactful Colombian neurosurgeon whose legacy is inextricably linked with the development of the neurosurgery specialty in Colombia. His detail-oriented approach to treatment complemented his reputation for mastery of the neurosciences. Never simply confined to the operating theater, this calm and considerate physician felt compelled to teach during his entire career. The result of his teaching made a lasting imprint on an entire generation of neurosurgeons who subsequently established a high standard of neurosurgical care in Colombia. A true pioneer, Bustamante comprehensively engaged in his field, from founding the country’s first residency program in neurosurgery to successfully implementing technology in his procedures, performing many of Colombia’s first neurosurgical interventions, and publishing extensively across various categories of medical science. This historical reflection highlights his enduring contributions to the field and considers his legacy through the witness testimony of many of his students and collaborators. The hope is that his contributions may be acknowledged in full, as he was a reserved person who never boasted of his own accomplishments. The authors also hope that those who did not have the opportunity to know him would be informed by the historical context of the development of Colombian neurosurgery and inspired by his conviction and altruism.
Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results
Authors: Cosgrove G. Rees , Lipsman Nir , Lozano Andres M. , Chang Jin Woo , Halpern Casey , Ghanouni Pejman , Eisenberg Howard , Fishman Paul , Taira Takaomi , Schwartz Michael L. , McDannold Nathan , Hayes Michael , Ro Susie , Shah Binit , Gwinn Ryder , Santini Veronica E. , Hynynen Kullervo , Elias W. Jeff
Published: August 2022

OBJECTIVE

The objective of this study was to evaluate, at 4 and 5 years posttreatment, the long-term safety and efficacy of unilateral MRI-guided focused ultrasound (MRgFUS) thalamotomy for medication-refractory essential tremor in a cohort of patients from a prospective, controlled, multicenter clinical trial.

METHODS

Outcomes per the Clinical Rating Scale for Tremor (CRST), including postural tremor scores (CRST Part A), combined hand tremor/motor scores (CRST Parts A and B), and functional disability scores (CRST Part C), were measured by a qualified neurologist. The Quality of Life in Essential Tremor Questionnaire (QUEST) was used to assess quality of life. CRST and QUEST scores at 48 and 60 months post-MRgFUS were compared to those at baseline to assess treatment efficacy and durability. All adverse events (AEs) were reported.

RESULTS

Forty-five and 40 patients completed the 4- and 5-year follow-ups, respectively. CRST scores for postural tremor (Part A) for the treated hand remained significantly improved by 73.3% and 73.1% from baseline at both 48 and 60 months posttreatment, respectively (both p < 0.0001). Combined hand tremor/motor scores (Parts A and B) also improved by 49.5% and 40.4% (p < 0.0001) at each respective time point. Functional disability scores (Part C) increased slightly over time but remained significantly improved through the 5 years (p < 0.0001). Similarly, QUEST scores remained significantly improved from baseline at year 4 (p < 0.0001) and year 5 (p < 0.0003). All previously reported AEs remained mild or moderate, and no new AEs were reported.

CONCLUSIONS

Unilateral MRgFUS thalamotomy demonstrates sustained and significant tremor improvement at 5 years with an overall improvement in quality-of-life measures and without any progressive or delayed complications.

Clinical trial registration no.: NCT01827904 (ClinicalTrials.gov)
Association of clinical outcomes and connectivity in awake versus asleep deep brain stimulation for Parkinson disease
Authors: Gadot Ron , Vanegas Arroyave Nora , Dang Huy , Anand Adrish , Najera Ricardo A. , Taneff Lisa Yutong , Bellows Steven , Tarakad Arjun , Jankovic Joseph , Horn Andreas , Shofty Ben , Viswanathan Ashwin , Sheth Sameer A.
Published: August 2022

OBJECTIVE

Deep brain stimulation (DBS) for Parkinson disease (PD) is traditionally performed with awake intraoperative testing and/or microelectrode recording. Recently, however, the procedure has been increasingly performed under general anesthesia with image-based verification. The authors sought to compare structural and functional networks engaged by awake and asleep PD-DBS of the subthalamic nucleus (STN) and correlate them with clinical outcomes.

METHODS

Levodopa equivalent daily dose (LEDD), pre- and postoperative motor scores on the Movement Disorders Society–Unified Parkinson’s Disease Rating Scale part III (MDS-UPDRS III), and total electrical energy delivered (TEED) at 6 months were retroactively assessed in patients with PD who received implants of bilateral DBS leads. In subset analysis, implanted electrodes were reconstructed using the Lead-DBS toolbox. Volumes of tissue activated (VTAs) were used as seed points in group volumetric and connectivity analysis.

RESULTS

The clinical courses of 122 patients (52 asleep, 70 awake) were reviewed. Operating room and procedure times were significantly shorter in asleep cases. LEDD reduction, MDS-UPDRS III score improvement, and TEED at the 6-month follow-up did not differ between groups. In subset analysis (n = 40), proximity of active contact, VTA overlap, and desired network fiber counts with motor STN correlated with lower DBS energy requirement and improved motor scores. Discriminative structural fiber tracts involving supplementary motor area, thalamus, and brainstem were associated with optimal clinical improvement. Areas of highest structural and functional connectivity with VTAs did not significantly differ between the two groups.

CONCLUSIONS

Compared to awake STN DBS, asleep procedures can achieve similarly optimal targeting—based on clinical outcomes, electrode placement, and connectivity estimates—in more efficient procedures and shorter operating room times.
COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion
Authors: Wang Yi , Sakaguchi Maki , Sabit Hemragul , Tamai Sho , Ichinose Toshiya , Tanaka Shingo , Kinoshita Masashi , Uchida Yasuo , Ohtsuki Sumio , Nakada Mitsutoshi
Published: August 2022

OBJECTIVE

An extracellular matrix such as collagen is an essential component of the tumor microenvironment. Collagen alpha-2(I) chain (COL1A2) is a chain of type I collagen whose triple helix comprises two alpha-1 chains and one alpha-2 chain. The authors’ proteomics data showed that COL1A2 is significantly higher in the blood of patients with glioblastoma (GBM) compared with healthy controls. COL1A2 has many different functions in various types of cancers. However, the functions of COL1A2 in GBM are poorly understood. In this study, the authors analyzed the functions of COL1A2 and its signaling pathways in GBM.

METHODS

Surgical specimens and GBM cell lines (T98, U87, and U251) were used. The expression level of COL1A2 was examined using GBM tissues and normal brain tissues by quantitative real-time polymerase chain reaction. The clinical significance of these levels was evaluated using Kaplan-Meier analysis. Small interfering RNA (siRNA) and small hairpin RNA of COL1A2 were transfected into GBM cell lines to investigate the function of COL1A2 in vitro and in vivo. Flow cytometry was introduced to analyze the alteration of cell cycles. Western blot and immunohistochemistry were performed to analyze the underlying mechanisms.

RESULTS

The expression level of COL1A2 was upregulated in GBM compared with normal brain tissues. A higher expression of COL1A2 was correlated with poor progression-free survival and overall survival. COL1A2 inhibition significantly suppressed cell proliferation in vitro and in vivo, likely due to G1 arrest. The invasion ability was notably deteriorated by inhibiting COL1A2. Cyclin D1, cyclin-dependent kinase 1, and cyclin-dependent kinase 4, which are involved in the cell cycle, were all downregulated after blockade of COL1A2 in vitro and in vivo. Phosphoinositide 3-kinase inhibitor reduced the expression of COL1A2. Although downregulation of COL1A2 decreased the protein kinase B (Akt) phosphorylation, Akt activator can phosphorylate Akt in siRNA-treated cells. This finding suggests that Akt phosphorylation is partially dependent on COL1A2.

CONCLUSIONS

COL1A2 plays an important role in driving GBM progression. COL1A2 inhibition attenuated GBM proliferation by promoting cell cycle arrest, indicating that COL1A2 could be a promising therapeutic target for GBM treatment.
Successful retrograde regeneration using a sensory branch for motor nerve transfer
Authors: Alzahrani Saud , Brito da Silva Harley , Chu Tak-Ho , Tariq Zain , Umansky Daniel , Elliott David A. , Midha Rajiv
Published: August 2022

OBJECTIVE

The objective of this study was to test whether regenerating motor axons from a donor nerve can travel in a retrograde fashion using sensory branches to successfully reinnervate a motor nerve end organ.

METHODS

This study has two parts. In part I, rats (n = 30) were assigned to one of five groups for obturator nerve (ON)–to–femoral nerve transfer: group 1, ON-to–saphenous nerve (SN) distal stump; group 2, ON-to-SN proximal stump without femoral nerve proper (FNP) injury; group 3, ON-to-SN proximal stump with FNP crush injury; group 4, ON-to-SN proximal stump with FNP transection injury; and group 5, gold standard transfer, ON-to–motor femoral nerve (MFN) branch. At 8 weeks, retrograde labeling was done from the distal MFN, and the spinal cords were examined to assess the degree of obturator motor axon regeneration across the five groups. In part II, only group 4 was examined (n = 8). Through use of immunostaining and optical tissue clearing methods, the nerve transfer networks were cleared and imaged using light-sheet fluorescence microscopy to visualize the regeneration pathways in 2D and 3D models at 2- and 8-week time points.

RESULTS

Proximal FNP transection (group 4) enabled a significantly higher number of retrogradely regenerated motor axons compared with control groups 1–3. Moreover, group 4 had modest, but nonsignificant, superiority of motor neuron counts compared with the positive control group, group 5. Optical tissue clearing demonstrated that the axons traveled in a retrograde fashion from the recipient sensory branch to the FNP mixed stump, then through complex turns, down to distal branches. Immunostaining confirmed the tissue clearing findings and suggested perineurium disruption as a means by which axons could traverse across fascicular boundaries.

CONCLUSIONS

Sensory branches can transmit regenerating axons from donor nerves back to main mixed recipient nerves, then distally toward target organs. The extent of retrograde regeneration is markedly influenced by the type and severity of injury sustained by the recipient nerve. Using a sensory branch as a bridge for retrogradely regenerating axons can open new potential horizons in nerve repair surgery for severely injured mixed nerves.
A review of the health benefits of Strychnos decussata (Pappe) Gilg (Loganiaceae): a potential functional food
Authors: Maroyi Alfred
Published: August 2022

Strychnos decussata is a small to medium sized tree which naturally occurs in open-wooded and thickets in tropical Africa. A critical appraisal of the medicinal, pharmacological and socio-economic properties of S. decussata are provided. Research articles focusing on the medicinal, pharmacological and socio-economic properties of S. decussata were searched from online databases such as Google Scholar, PubMed, Science Direct, SciELO and SpringerLink. No time limit was set for the search and all research outputs that aligned with the scope of the review were included. S. decussata has diverse uses as a food plant and also has medicinal uses such as charm and ritual, scorpion and snake bite antidote, ethnoveterinary medicine, and traditional medicine for fever, gastro-intestinal problems, headache, respiratory infections, wounds, venereal diseases and infections. S. decussata exert biological activities such as antifungal, antimycobacterial, antiplasmodial and convulsant activities. Several phytochemical compounds such as decussine and decussine-type alkaloids, gluco-indole alkaloids and pentacyclic indole alkaloids have been isolated from the species. Many applications of S. decussata as source of food and herbal medicines as well as its phytochemistry and pharmarcological properties need further investigations.Keywords: Buddleia family, ethnomedicinal uses, indigenous knowledge, Loganiaceae, Strychnos decussata
Time is a thief of memory
Authors: Wise Alicia
Published: August 2022

This paper is based upon a presentation during the session ‘The Version of Record under Attack! The Dark Side of the Scholarly Publishing Universe’ at the 17th APE Conference. It discusses the complex challenges of long-term digital preservation and how CLOCKSS is collaborating with publishers, libraries, and other stakeholders to preserve digital scholarship over the coming centuries.
Hybrid connected attentional lightweight network for gangue intelligent segmentation in top-coal caving face
Authors: Fu Chengcai , Lu Fengli , Wu Fan , Zhang Guoying
Published: August 2022

The estimation of gangue content is the main basis for intelligent top coal caving mining by computer vision, and the automatic segmentation of gangue is crucial to computer vision analysis. However, it is still a great challenge due to the degradation of images and the limitation of computing resources. In this paper, a hybrid connected attentional lightweight network (HALNet) with high speed, few parameters and high accuracy is proposed for gangue intelligent segmentation on the conveyor in the top-coal caving face. Firstly, we propose a deep separable dilation convolution block (DSDC) combining deep separable convolution and dilation convolution, which can provide a larger receptive field to learn more information and reduce the size and computational cost of the model. Secondly, a bridging residual learning framework is designed as the basic unit of encoder and decoder to minimize the loss of semantic information in the process of feature extraction. An attention fusion block (AFB) with skip pathway is introduced to capture more representative and distinctive features through the fusion of high-level and low-level features. Finally, the proposed network is trained through the expanded dataset, and the gangue image segmentation results are obtained by pixel-by-pixel classification method. The experimental results show that the proposed HALNet reduces about 57 percentage parameters compared with U-Net, and achieves state-of-the art performance on dataset.
State monadic residuated lattices and their corresponding filters
Authors: Wang Juntao , Kang Mengna , Fu Xuesong , Li Fei
Published: August 2022

In this paper, we introduce the notion of state monadic residuated lattices and study some of their related properties. Then we prove that the relationship between state monadic algebras of substructural fuzzy logics completely maintains the relationship between corresponding monadic algebras. Moreover, we introduce state monadic filters of state monadic residuated lattice, giving a state monadic filter generated by a nonempty subset of a residuated lattice, and obtain some characterizations of maximal and prime state monadic filters. Finally, we give some characterization of special kinds of state monadic residuated lattices, including simple, semisimple and local state monadic residuated lattices by state monadic filters.
Importance of clustering Improve of Modified Bee Colony Optimization (MBCO) algorithm by optimizing the clusters initial values
Authors: Cai Jinya , Zhang Haiping , Yu Xinping
Published: August 2022

The modified bee colony algorithm is one of the excellent methods that has been proposed in recent years for data clustering. This MBCO algorithm randomly values the primary centers of the cluster by selecting a number of data from the data set, which makes the algorithm sensitive to the presence of noise and outgoing data in the data set and reduces its performance. Therefore, to solve this problem, the proposed method used three approaches to quantify the initial centers of the clusters. In the proposed method, first the initial centers of the clusters are generated by chaos methods, KMeans++algorithm and KHM algorithm to determine the optimal position for the centers. Then the MBCO algorithm starts working with these centers. The performance of the proposed method compared to a number of other clustering methods was evaluated on 7 UCI datasets based on 6 clustering evaluation criteria. For example, in the iris data set, the proposed method with chaos approaches, KHM and KMeans++with accuracy of 0.8725, 0.8737 and 0.8725, respectively, and the MBCO method with accuracy of 0.8678, and in terms of CH criteria, the proposed method with chaotic approaches, KHM and KMeans++reached values of 0.3901, 0.54848, 0.5147 and MBCO method of 0.3620, respectively. Better achieved. In general, the results of the experiments according to the 6 evaluation criteria showed better performance of the proposed method compared to other methods in most data sets according to the 6 evaluation criteria.
Cost-Effectiveness and Cost-Utility of Early Levodopa in Parkinson’s Disease
Authors: Verschuur Constant V.M. , Suwijn Sven R. , de Haan Rob J. , Boel Judith A. , Post Bart , Bloem Bas R. , van Hilten Johannes J. , van Laar Teus , Tissingh Gerrit , Munts Alexander , Dijkgraaf Marcel G.W. , de Bie Rob M.A.
Published: August 2022

Background:

In the Levodopa in EArly Parkinson’s disease (LEAP) study, 445 patients were randomized to levodopa/carbidopa 100/25 mg three times per day for 80 weeks (early-start) or placebo for 40 weeks followed by levodopa/carbidopa 100/25 mg three times per day for 40 weeks (delayed-start).

Objective:

This paper reports the results of the economic evaluation performed alongside the LEAP-study.

Methods:

Early-start treatment was evaluated versus delayed-start treatment, in which the cost-effectiveness analysis (CEA) and the cost-utility analysis (CUA) were performed from the societal perspective, including health care costs among providers, non-reimbursable out-of-pocket expenses of patients, employer costs of sick leave, and lowered productivity while at work. The outcome measure for the CEA was the extra cost per unit decrease on the Unified Parkinson’s Disease Rating Scale 80 weeks after baseline. The outcome measure for the CUA was the extra costs per additional quality adjusted life year (QALY) during follow-up.

Results:

212 patients in the early-start and 219 patients in the delayed-start group reported use of health care resources. With savings of € 59 per patient (BCa 95% CI: –829, 788) in the early-start compared to the delayed-start group, societal costs were balanced. The early-start group showed a mean of 1.30 QALYs (BCa 95% CI: 1.26, 1.33) versus 1.30 QALYs (BCa 95% CI: 1.27, 1.33) for the delayed-start group. Because of this negligible difference, incremental cost-effectiveness and cost-utility ratios were not calculated.

Conclusion:

From an economic point of view, this study suggests that early treatment with levodopa is not more expensive than delayed treatment with levodopa.
Predicting athletic performance from physiological parameters using machine learning: Example of bocce ball
Authors: Şimşek Mehmet , Kesilmiş İnci
Published: August 2022

Machine learning (ML) is an emerging topic in Sports Science. Some pioneering studies have applied machine learning to prevent injuries, to predict star players, and to analyze athletic performance. The limited number of studies in the literature focused on predicting athletic performance have adopted the cluster-then-predict classification approach. However, these studies have used the independent variable to represent athletic performance at both the clustering and classification stages. In this study we used only physiological parameters in the classification of bocce athletes. Their performance classes were predicted with high accuracy, thus contributing new findings to the literature. The support vector machines-radial basis function (SVM-RBF) kernel correctly predicted all athletes from the high-performance bocce player (HPBP) cluster and 75% of the athletes in the low-performance bocce player (LPBP) cluster. Using machine learning to predict athletic performance from balance data was found to be a time-saving approach for selecting high-potential bocce athletes.
Linking mental health to safety behavior in construction workers: The mediating effect of work ability and sleep quality
Authors: Mahdinia Mohsen , Mohammadfam Iraj , Aliabadi Mostafa Mirzaei , Hamta Amir , Soltanzadeh Ahmad
Published: August 2022

BACKGROUND: The severity of occupational accidents and injuries in the construction industry is the greatest across all industries. Few studies have examined the causal relationships among physical and psychological variables affecting the safety behavior of construction workers. OBJECTIVE: This study aimed to investigate the relationships among three factors (metal health, work ability and sleep quality) influencing the safety behavior of construction workers. METHODS: This cross-sectional study was conducted on 204 workers in civil construction projects in Iran. The data were gathered via self-reporting questionnaires. The acquired data were analyzed by the Smart PLS3 software using structural equation modeling with the partial least squares (PLS) regression approach. RESULTS: The R square revealed an acceptable fineness of the structural model. Similarly, as Q square values were higher than 0.15 for all factors, the predictability of the model was approved. The direct effect of mental health on safety behavior was not significant, but work ability and sleep quality had significant direct effects on safety behavior. Moreover, a decrease in mental health significantly reduced construction workers’ sleep quality and work ability. CONCLUSION: The results of this study prove that sleep quality and work ability mediate the relationship between mental health and safety behavior. The deterioration of construction workers’ mental health can increase the risk of unsafe behavior and occupational injuries. Therefore, appropriate measures need to be taken to maintain and improve the mental health of construction workers.
Utilization rates of Active Release Techniques® in the workplace: A descriptive study
Authors: Pajaczkowski Jason
Published: August 2022

BACKGROUND: Workplace safety is a necessary and frequent topic of discussion for researchers, employers, and workers. It is estimated that annual losses caused by work-related injuries cost the United States $140 to $145 billion. Specifically, work-related musculoskeletal disorders (WMSD) have risen from just over 10% to 50% of the total claims from 1952 to 1996, accounting for more than 345,00 days lost and more than $57 million in WSIB costs in 2015. Novel approaches to managing WMSDs, such as Active Release Techniques®, need to be explored to ensure the ongoing health of workers. OBJECTIVE: This descriptive study provides the details of the 697,002 onsite treatments across 448 sites in North America between 2014–2018 provided by Active Release Techniques® Corporate Solutions (ARTCS) practitioners. The objective was to calculate the total number of treatments, cost per closed case, percent improvement, and the number of cases referred to worker’s compensation. METHODS: All charting was done on the ARTCS EMR portal. The lead author was given a spreadsheet of the results sanitized of all identifying data in order to perform the aforementioned calculations. RESULTS: From 2014 to 2018, ARTCS providers opened 199,077 new cases, with an average cost to the employer of $306.69 USD per case and an average percent improvement in pain (VNPS) of 87.2%. The most frequently treated areas were the shoulder (32,574 cases), hip (6,633 cases), and low back (27,873 cases), respectively. A total of 48,946 cases were work-related pain/discomfort, of which 1,110 (2.27%) went on to worker’s compensation. CONCLUSION: ARTCS in the workplace has shown a positive trend in terms of reducing pain intensity. The cost was low as compared to worker’s compensation claims, as was the rate of cases (2.27%) referred to worker’s compensation. Additional studies, including prospective data collection and a control group, are warranted to substantiate this.
Office workspace for an ageing workforce: A systematic review
Authors: Oberti Ilaria , Plantamura Francesca
Published: August 2022

BACKGROUND: With the ageing of the working population, it is becoming crucial empowering staff of all ages to perform at its best. To this end, organizations can act on the built environment, adapting the workspace to the changing characteristics of workers and using it as a tool for health promotion. OBJECTIVE: To provide an overview of office workspace requirements to optimise the wellbeing and productivity of older workers. METHODS: The search, by Scopus, Web of Science core collection and Medline, produced 290 records. The screening process, according to the Prisma method, reduced the records to 13 included in the review. RESULTS: The results show the needs and preferences of the ageing workforce, such as personal control over the environment in terms of both comfort and use of space, as well as negative opinions on specific solutions, such as the extensive use of open offices and the introduction of shared workstations. The included studies report mainly subjective data, derived from interviews and questionnaires. CONCLUSIONS: The review provides a first framework for acting on the office workspace to improve wellbeing and productivity of older workers. However, further studies, evidence-based and with subjective and objective measurements of specific solutions, are needed to develop guidelines for an inclusive workspace for all ages.
Methodological considerations in the open-plan office paradox: A systematic literature review
Authors: Bennis Will M. , Mayerhoffer Manuel , Orel Marko , Lukeš Martin
Published: August 2022

BACKGROUND: Several recent reports conclude that open-plan offices negatively impact workers across a variety of outcome measures. This contrasts to a corporate trend to move from cellular to open-plan layouts, often justified by the same outcomes. Two explanations for this paradox are proposed: (1) the results are more complicated than critical reports suggest, and (2) methodological biases make open-plan layouts look more negative than they are. OBJECTIVE: To evaluate the proposed explanations using a systematic literature review. METHODS: Google Scholar was used to find original research on the relationship between office openness and worker outcomes. 89 articles were coded for the variables and methods they used, and conclusions about the relationship between layout and outcomes were evaluated. RESULTS: The proposed explanations were partly supported. The relationship between layout openness and worker outcomes depends on the variables considered and the methods used, and a small subset of methods was used far more often than others. That said, more research is needed to evaluate impact of open-plan offices on worker outcomes. CONCLUSIONS: The relationship between office openness and worker outcomes varies widely depending on how it is measured. Several promising areas for future research may help clarify this relationship.
ТЕОРЕТИЧНІ ОСНОВИ ФОРМУВАННЯ ГОТОВНОСТІ МОЛОДШИХ ІНСПЕКТОРІВ ПРИКОРДОННОЇ СЛУЖБИ ДО ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ У ПУНКТАХ ПРОПУСКУ ДЛЯ МІЖНАРОДНОГО СПОЛУЧЕННЯ
Authors: АДАМЧУК Юлія
Published: August 2022

У статті автор визначає сутність і компоненти готовності молодших інспекторів прикордонної служби до професійної діяльності у пунктах пропуску для міжнародного сполучення. Готовність молодших інспекторів прикордонної служби до професійної діяльності у пунктах пропуску для міжнародного сполучення є професійно важливою особистісною властивістю, що охоплює відповідний рівень мотивації до професійної діяльності, сформованість умінь приймати рішення, психологічну готовність до професійної діяльності, здатність до застосування знань, умінь і навичок для ідентифікації осіб і транспортних засобів, огляду транспортних засобів, підтримання режиму у пунктах пропуску через державний кордон тощо. На основі осмислення специфіки оперативно-службової діяльності встановлено, що готовність молодших інспекторів прикордонної служби до професійної діяльності у пунктах пропуску для міжнародного сполучення містить такі компоненти: мотиваційний, психологічний, діяльнісний. Мотиваційний компонент виявляться через інтерес до професійної діяльності, ставлення до професійної, відповідальність за власні дії, усвідомлення значущості професійної діяльності у пунктах пропуску для міжнародного сполучення. Психологічний компонент характеризує сформованість психічних якостей, здатність до рефлексії в оцінці власних дій, сформованість умінь приймати рішення, психологічну готовність до професійної діяльності у пунктах пропуску для міжнародного сполучення. Діяльнісний компонент виражається в умінні застосовувати набутий професійний досвід, здатності до дій в нових умовах, самооцінці своєї професійної діяльності та прийнятих рішень; в умінні прогнозувати діяльність у пунктах пропуску для міжнародного сполучення.
ОЦІНКА ПОІНФОРМОВАНОСТІ СТУДЕНТІВ ПРО РОЛЬ РУХОВОЇ АКТИВНОСТІ У ЖИТТЄДІЯЛЬНОСТІ МОЛОДІ
Authors: БАЗИЛЬЧУК Віра
Published: August 2022

У науковій статті здійснено компаративний аналіз літературних джерел з проблем формування здорового способу життя студентів закладів вищої освіти. Зазначено, що стан здоров’я студентської молоді, є невід’ємною складовою здоров’я нації загалом і має стратегічне значення для забезпечення сталого розвитку суспільства. Адже дослідження стану здоров’я студентської молоді як майбутньої еліти країни свідчать про те, що в сучасному суспільстві відбуваються докорінні зміни умов життя, праці й побуту населення. Акцентовано увагу на тому, що студенти зазвичай сприймають здоров’я як природну даність і звертають на нього увагу лише тоді, коли відбуваються помітні порушення. Серед причин такого ставлення здобувачів вищої освіти є недостатні знання про здоров’я, механізми і способи його формування та зміцнення. Указано на необхідність гострої суспільної потреби у формуванні здорового способу життя молодого покоління. Наголошується, що для формування навичок здорового способу життя важливим є впровадження в повсякденне життя рекомендацій щодо раціонального режиму праці, відпочинку, харчування, рухової активності, загартування та профілактики шкідливих звичок. Оскільки рухова активність є складовою здорового способу життя, яка забезпечує розвиток фізичних якостей, підтримку і зміцнення здоров’я та є ознакою повноцінного життя й діяльності студентської молоді, рекомендовано систематичні заняття фізичними вправами, які підвищують опірність організму до несприятливих факторів зовнішнього середовища та стійкість до емоційних стресів під час навчання і сесій. Розкрито рівень поінформованості студентів про роль їх рухової активності та наслідки малорухомості чи надмірної рухової активності. Виявлено достатній рівень зацікавленості у вивченні проблеми рухової активності студентів і позитивний тісний взаємозв’язок з цікавістю майбутніх фахівців зі здоров’язбережувальною компетентністю до обраної ними професії.
ДИСТАНЦІЙНІ ПЛАТФОРМИ ДЛЯ НАВЧАННЯ І САМОРОЗВИТКУ ЗДОБУВАЧІВ ВИЩОЇ ОСВІТИ НА ЗАНЯТТЯХ З “УКРАЇНСЬКОЇ МОВИ ЗА ПРОФЕСІЙНИМ СПРЯМУВАННЯМ” ПІД ЧАС ВОЄННОГО СТАНУ
Authors: ГОЛЯРДИК Наталія , ГЕВКО Олена , МАКОГОНЧУК Наталія
Published: August 2022

Російсько-українська війна має трагічний і катастрофічний вплив на нормальне функціонування усіх сфер діяльності. Система освіти у цей період зазнала серйозних змін через бойові дії, обстріли, евакуацію тощо. За цих умов основною проблемою стало невідкладне впровадження ефективних рішень для проведення процесів дистанційного викладання, навчання та саморозвитку з огляду на індивідуальні потреби студентів. Слід зазначити, що система освіти відреагувала миттєво, завдяки досвіду пандемії COVID-19. Проведення онлайн-викладацької діяльності не було новим рішенням, ця система добре налагоджена та відпрацьована. Утім, реалії війни (руйнування засобів зв’язку, погане підключення через роботу з укриттів, підключення студентів із-за кордону) поставили умову пошуку нових рішень, а саме: пошуку нових, більш потужних дистанційних платформ. У цьому контексті платформи e-Learning стали рятівними та ефективними для надання освітнього вмісту великій кількості студентів та у проведенні індивідуальних освітніх заходів. Напад Росії поклав акцент на розробці та вдосконаленні засобів синхронної навчальної діяльності. У роботі проаналізовано три платформи електронного навчання, та обрано дві для використання здобувачами вищої освіти на заняттях з предмета “Українська мова за професійним спрямуванням” під час воєнного стану. Запропоновано низку заходів для отримання вищої освіти в контексті надзвичайних ситуацій і воєнного стану. Виявлено основні критерії для вибору дистанційної платформи та проблемні моменти, які їх визначають (умови та можливості технічного доступу до навчання, часові рамки, технічні можливості, потреба в індивідуальній взаємодії викладачів та студентів). Робимо висновок про доцільність одночасного використання дистанційних платформ Google meet та Microsoft Teams, оскільки таке поєднання дає змогу ефективно долучати до навчального процесу всіх студентів (синхронно та асинхронно) та зважати на їх індивідуальні потреби, пов’язані з воєнною агресією з боку Росії на території України.
ЛІДЕРСЬКА КОМПЕТЕНТНІСТЬ ЯК ПРЕДМЕТ НАУКОВИХ ДОСЛІДЖЕНЬ
Authors: ДІДЕНКО Олександр , КОСТЮЧЕНКО Максим
Published: August 2022

У статті охарактеризовано проблематику лідерства як важливий предмет наукових досліджень. З’ясовано, що ці дослідження започатковано ще в епоху античності, коли відомі філософи виокремили важливі якості лідера – суспільного діяча і військового керівника. З часом трактування лідерства відійшло від розгляду суто особистісних якостей до розроблення всеохопних теорій цього феномену.Доведено, що на сьогодні дослідження проблематики лідерства здійснюють у теорії управління, менеджменті, соціології, психології та педагогіці. У теорії управління і менеджменті лідерство трактують насамперед як міжособистісну взаємодію, що визначається конкретною ситуацією на основі комунікативного процесу і спрямоване на досягнення мети. Представники економічної науки розглядають лідерство як важливий ресурс підвищення ефективності діяльності підприємства. У дослідженнях з менеджменту поняття лідерства розглядають у контексті управлінській взаємодії між лідером і колективом, як процес несилового впливу для досягнення організацією своїх цілей та організаційної ефективності. У сучасних організаціях лідерство пов’язують зі знаннями та досвідом. Лідерство вчені розглядають у декількох аспектах: співвідносно з людиною та її якостями, становищем в організації; співвідносно з процесом (взаємовідносинами в організації) і з огляду на результати діяльності.Автор з’ясував, що проблематика лідерства є також предметом ґрунтовного зацікавлення представників соціологічної, психологічної та педагогічної галузей знань. Соціологи звертають увагу на роль лідерів у різних соціальних групах, своєю чергою психологів цікавить лідерство як соціально-психологічний феномен внутрішнього розвитку групи, як один з процесів організації й управління малою соціальною групою. У психології вивчають переважно особистісні якості лідера, розглядаючи його як важливу складову системи міжособистісних відносин у групі, вияв відносин домінування й підпорядкування.Своєю чергою педагогіка, розглядаючи лідерство як складне соціально-психологічне явище, індивідуальне утворення, зосереджується на визначенні шляхів і підходів формування лідерських якостей, розвитку лідерського потенціалу людини. Загалом дослідники визначили ті особистісні складові офіцера-лідера, які, на їхню думку, допоможуть йому більш ефективно налагоджувати взаємодію з підлеглими та ув’язненими та більш ефективно досягати цілей професійної діяльності.