bluuebunny/crossref_metadata_2025 huggingface dataset:
Catalytic Oxidation of Hydrocarbons
Authors: Carabineiro Sónia Alexandra Correia
Published: January 2024

The catalytic oxidation of hydrocarbons stands at the forefront of sustainable chemical transformations, offering pathways to selectively convert aliphatic and aromatic compounds into valuable oxygenated products [...]
Heterogeneous Photocatalytic Oxidation and Detoxification of Simulated Agricultural Wastewater Contaminated with Boscalid Fungicide Using g-C3N4 Catalyst
Authors: Antonopoulou Maria , Tzamaria Anna , Miserli Kleopatra , Lykos Christos , Konstantinou Ioannis
Published: January 2024

In the present study, the photocatalytic oxidation and detoxification of aqueous matrices contaminated with boscalid using g-C3N4 catalyst and UV-A light was investigated. The UV-A/g-C3N4 process was found to achieve higher than 83% removal of boscalid in both matrices, with h+ and O2•− being the main species. UHPLC-HRMS analysis allowed the identification of five TPs, while the main degradation pathways involved hydroxylation, cyclization, and dechlorination. Scenedesmus rubescens microalgae species was exposed to boscalid solutions and lake water spiked with the fungicide before the photocatalytic treatment and inhibition in the growth rate was observed. An increase in the toxicity was also observed during the first stages of the treatment. The results from the in silico study correlate with the observed evolution of ecotoxicity during the application of the process, as some of the identified TPs were found to be toxic or very toxic for aquatic organisms. However, prolonged application of the process can lead to detoxification. It was also observed that the g-C3N4 catalyst can retain its photochemical stability and activity after at least three cycles. However, a slight decrease in the activity was observed when repeated another two times. This study demonstrated that the suggested photocatalytic process can both decrease the harmful effects of boscalid as well as effectively lower its concentration in water.
β2-Adrenoceptor Activation Favor Acquisition of Tumorigenic Properties in Non-Tumorigenic MCF-10A Breast Epithelial Cells
Authors: Silva Dany , Quintas Clara , Gonçalves Jorge , Fresco Paula
Published: January 2024

Noradrenaline and adrenaline, and their cognate receptors, are currently accepted to participate in cancer progression. They may also participate in cancer initiation, although their role in this phase is much less explored. The aim of this work was to study the influence of adrenergic stimulation in several processes related to breast cancer carcinogenesis, using several adrenergic agonists in the MCF-10A non-tumorigenic breast cells. Activation of the β-adrenoceptors promoted an epithelial phenotype in MCF-10A cells, revealed by an increased expression of the epithelial marker E-cadherin and a decrease in the mesenchymal markers, N-cadherin and vimentin. MCF-10A cell motility and migration were also impaired after the β-adrenoceptors activation. Concomitant with this effect, β-adrenoceptors decrease cell protrusions (lamellipodia and filopodia) while increasing cell adhesion. Activation of the β-adrenoceptors also decreases MCF-10A cell proliferation. When the MCF-10A cells were cultured under low attachment conditions, activation the of β- (likely β2) or of α2-adrenoceptors had protective effects against cell death, suggesting a pro-survival role of these adrenoceptors. Overall, our results showed that, in breast cells, adrenoceptor activation (mainly through β-adrenoceptors) may be a risk factor in breast cancer by inducing some cancer hallmarks, providing a mechanistic explanation for the increase in breast cancer incidences that may be associated with conditions that cause massive adrenergic stimulation, such as stress.
Unraveling the Signaling Dynamics of Small Extracellular Vesicles in Cardiac Diseases
Authors: Caño-Carrillo Sheila , Castillo-Casas Juan Manuel , Franco Diego , Lozano-Velasco Estefanía
Published: January 2024

Effective intercellular communication is essential for cellular and tissue balance maintenance and response to challenges. Cellular communication methods involve direct cell contact or the release of biological molecules to cover short and long distances. However, a recent discovery in this communication network is the involvement of extracellular vesicles that host biological contents such as proteins, nucleic acids, and lipids, influencing neighboring cells. These extracellular vesicles are found in body fluids; thus, they are considered as potential disease biomarkers. Cardiovascular diseases are significant contributors to global morbidity and mortality, encompassing conditions such as ischemic heart disease, cardiomyopathies, electrical heart diseases, and heart failure. Recent studies reveal the release of extracellular vesicles by cardiovascular cells, influencing normal cardiac function and structure. However, under pathological conditions, extracellular vesicles composition changes, contributing to the development of cardiovascular diseases. Investigating the loading of molecular cargo in these extracellular vesicles is essential for understanding their role in disease development. This review consolidates the latest insights into the role of extracellular vesicles in diagnosis and prognosis of cardiovascular diseases, exploring the potential applications of extracellular vesicles in personalized therapies, shedding light on the evolving landscape of cardiovascular medicine.
Evaluating the Mechanism of Cell Death in Melanoma Induced by the Cannabis Extract PHEC-66
Authors: Bachari Ava , Nassar Nazim , Telukutla Srinivasareddy , Zomer Roby , Piva Terrence J. , Mantri Nitin
Published: January 2024

Research suggests the potential of using cannabinoid-derived compounds to function as anticancer agents against melanoma cells. Our recent study highlighted the remarkable in vitro anticancer effects of PHEC-66, an extract from Cannabis sativa, on the MM418-C1, MM329, and MM96L melanoma cell lines. However, the complete molecular mechanism behind this action remains to be elucidated. This study aims to unravel how PHEC-66 brings about its antiproliferative impact on these cell lines, utilising diverse techniques such as real-time polymerase chain reaction (qPCR), assays to assess the inhibition of CB1 and CB2 receptors, measurement of reactive oxygen species (ROS), apoptosis assays, and fluorescence-activated cell sorting (FACS) for apoptosis and cell cycle analysis. The outcomes obtained from this study suggest that PHEC-66 triggers apoptosis in these melanoma cell lines by increasing the expression of pro-apoptotic markers (BAX mRNA) while concurrently reducing the expression of anti-apoptotic markers (Bcl-2 mRNA). Additionally, PHEC-66 induces DNA fragmentation, halting cell progression at the G1 cell cycle checkpoint and substantially elevating intracellular ROS levels. These findings imply that PHEC-66 might have potential as an adjuvant therapy in the treatment of malignant melanoma. However, it is essential to conduct further preclinical investigations to delve deeper into its potential and efficacy.
A CFD Analysis of the Desalination Performance of Ceramic-Based Hollow Fiber Membranes in Direct Contact Membrane Distillation
Authors: Alrefaai MHD Maher , Othman Mohd Hafiz Dzarfan , Rava Mohammad , Tai Zhong Sheng , Asnaghi Abolfazl , Puteh Mohd Hafiz , Jaafar Juhana , Rahman Mukhlis A. , Al-Ogaili Mohammed Faleh Abd
Published: January 2024

In this numerical study, the performance of ceramic-based mullite hollow fiber (HF) membranes in a direct contact membrane distillation (DCMD) process was evaluated. Three types of membranes were tested: (i) hydrophobic membrane C8-HFM, (ii) rod-like omniphobic membrane (C8-RL/TiO2), and (iii) flower-like omniphobic membrane (C8-FL/TiO2). The CFD model was developed and validated with experimental results, which were performed over a 500 min period. The initial mass flux of C8-HFM was 30% and 9% higher than that of C8-FL/TiO2 and C8-RL/TiO2, respectively. However, the flower-like omniphobic membrane C8-FL/TiO2 had the lowest drop in flux, around 11%, while the rod-like omniphobic membrane C8-RL/TiO2 had a 15% reduction, both better than the 23% reduction in the hydrophobic membrane C8-HFM over the 500 min. The study also analyzed the impact of fouling by examining the variation in mass transfer coefficient (MTC) over time. The results indicated that the ceramic-based mullite HF membranes with TiO2 flowers and rods demonstrated a high resistance to fouling compared to C8-HFM. The modified membranes could find applications in the desalination and handling of seawater samples containing organic contaminants. The CFD model’s versatility can be utilized beyond the current investigation’s scope, offering a valuable tool for efficient membrane development solutions, particularly for challenges such as the presence of organic contaminants in seawater.
Archaeometric Investigations on Archaeological Findings from Palazzo Corsini Alla Lungara (Rome)
Authors: de Caro Tilde , Susanna Fiammetta , Fraiegari Paola , Sebastiani Renato , Romoli Veronica , Bruno Simone , Macchia Andrea
Published: January 2024

This study reports the analytical investigations on clayey and ceramic finds, characterised by high variability in terms of prime materials, with the aim to determine the role of this important ceramic production situated close to the city walls, fortuitously found during service excavations developed in the garden of Palazzo Corsini in Rome. The complexity of the finds led to the choices of appropriate methodologies and techniques suitable for defining the diagnostic elements of each find. Optical microscopy (OM) combined with micro-Raman (µ-Raman) spectroscopy, X-ray diffractometry (XRD), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDS), and differential thermal analysis (DTA) were used to analyse the nature and microstructure of the ceramic and burned clay that were found. In such a complicated setting, the objective of conducting chemical analyses is to provide clues to describe the various kinds of ceramics produced, the production and processing methods, and, as a result, the typology of the workshop.
Pioneering Synthetic Strategies of 2-Substituted Benzothiazoles Using 2-Aminothiophenol
Authors: Teli Sunita , Sethiya Ayushi , Agarwal Shikha
Published: January 2024

Heterocycles, compounds featuring heteroatoms like nitrogen, sulfur, and oxygen, are integral in fields such as synthesis, pharmacology, and medicine. Among these, benzothiazoles, formed by fusing thiazole with benzene, hold significant prominence. Their unique reactivity, especially at the carbon position between nitrogen and sulfur, has sparked wide interest. Notably, 2-substituted benzothiazoles exhibit diverse biological activities, including anticonvulsant, antimicrobial, and antioxidant properties, making them valuable in drug discovery. This review unveils an array of mesmerizing methods employed by chemists to prepare these compounds using 2-aminothiophenol as one of the precursors with other varied reactants. From novel strategies to sophisticated methodologies, each section of this review provides a glimpse into the fascinating world of synthetic chemistry of 2-substituted benzothiazoles. Delving into the diverse synthetic applications of 2-substituted benzothiazoles, this paper not only enriches our understanding of their synthesis but also sparks the imagination with the possibilities for future advancements.
Correction: Wei et al. Self-Assembled Corn-Husk-Shaped Fullerene Crystals as Excellent Acid Vapor Sensors. Chemosensors 2022, 10, 16
Authors: Wei Zexuan , Song Jingwen , Ma Renzhi , Ariga Katsuhiko , Shrestha Lok Kumar
Published: January 2024

The authors make the following corrections to the published paper [...]
Next Generation Sequencing and Electromyography Reveal the Involvement of the P2RX6 Gene in Myopathy
Authors: Vinci Mirella , Vitello Girolamo , Greco Donatella , Treccarichi Simone , Ragalmuto Alda , Musumeci Antonino , Fallea Antonio , Federico Concetta , Calì Francesco , Saccone Salvatore , Elia Maurizio
Published: January 2024

Ion channelopathies result from impaired ion channel protein function, due to mutations affecting ion transport across cell membranes. Over 40 diseases, including neuropathy, pain, migraine, epilepsy, and ataxia, are associated with ion channelopathies, impacting electrically excitable tissues and significantly affecting skeletal muscle. Gene mutations affecting transmembrane ionic flow are strongly linked to skeletal muscle disorders, particularly myopathies, disrupting muscle excitability and contraction. Electromyography (EMG) analysis performed on a patient who complained of weakness and fatigue revealed the presence of primary muscular damage, suggesting an early-stage myopathy. Whole exome sequencing (WES) did not detect potentially causative variants in known myopathy-associated genes but revealed a novel homozygous deletion of the P2RX6 gene likely disrupting protein function. The P2RX6 gene, predominantly expressed in skeletal muscle, is an ATP-gated ion channel receptor belonging to the purinergic receptors (P2RX) family. In addition, STRING pathways suggested a correlation with more proteins having a plausible role in myopathy. No previous studies have reported the implication of this gene in myopathy. Further studies are needed on patients with a defective ion channel pathway, and the use of in vitro functional assays in suppressing P2RX6 gene expression will be required to validate its functional role.
A Narrative Review of Current Knowledge on Cutaneous Melanoma
Authors: Caraban Bogdan Marian , Aschie Mariana , Deacu Mariana , Cozaru Georgeta Camelia , Pundiche Mihaela Butcaru , Orasanu Cristian Ionut , Voda Raluca Ioana
Published: January 2024

Cutaneous melanoma is a public health problem. Efforts to reduce its incidence have failed, as it continues to increase. In recent years, many risk factors have been identified. Numerous diagnostic systems exist that greatly assist in early clinical diagnosis. The histopathological aspect illustrates the grim nature of these cancers. Currently, pathogenic pathways and the tumor microclimate are key to the development of therapeutic methods. Revolutionary therapies like targeted therapy and immune checkpoint inhibitors are starting to replace traditional therapeutic methods. Targeted therapy aims at a specific molecule in the pathogenic chain to block it, stopping cell growth and dissemination. The main function of immune checkpoint inhibitors is to boost cellular immunity in order to combat cancer cells. Unfortunately, these therapies have different rates of effectiveness and side effects, and cannot be applied to all patients. These shortcomings are the basis of increased incidence and mortality rates. This study covers all stages of the evolutionary sequence of melanoma. With all these data in front of us, we see the need for new research efforts directed at therapies that will bring greater benefits in terms of patient survival and prognosis, with fewer adverse effects.
Fabrication of Air Conditioning Antimicrobial Filter for Electrically Powered Port Tractors via Electrospinning Coating
Authors: Yoon Sam-Ki , Pahn Lyong-Oon , Kyun Jeong-Jong , Cho Soon-Hwan
Published: January 2024

With the stricter emission regulations for internal combustion engines, electric vehicles, including electrically powered port tractors, have received increasing attention. However, currently, most of the filters used in electric vehicles are conventional membranes that only have the function of filtering particles and foreign objects. Therefore, in order to improve the above issues, the surface of commercial non-woven filter membranes was coated with Ag nanopowder nanofibers and AgNO3 nanofibers via electrospinning. At present, the comparative research on the antibacterial ability of Ag nanopowder and AgNO3 is still blank in the same research system, especially with the use of electrospun coating technology. The morphologies and structures of non-woven fabrics and electrospinning coated samples were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The characterization results indicate that both pure PVA and PVA composite fibers can be successfully coated on the surface of non-woven fabrics. The average diameter of all electrospun PVA composite fibers is distributed in the range of 470–700 nm. The PVA nanofibers with a low content of 1 wt% AgNO3 have good antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), with clearance clear zones of inhibition of 26.00 mm and 17.30 mm, respectively.
Design of High-Modulus Asphalt Concrete for the Middle Layer of Asphalt Pavement
Authors: Li Bin , Liu Zengxin , Li Meng , Fei Yanhua , Yi Junyan
Published: January 2024

This article investigates the application of high-modulus asphalt mixtures (HMM-13) in the intermediate layer of pavement, addressing rutting issues in asphalt pavements subjected to heavy traffic and high temperatures. The study utilized a 1% dosage of high-modulus modifier, and initially, the mix design of HMM-13 was determined using the gyratory compaction method. Subsequently, this study evaluated the road performance of HMM-13 through tests, including the −10 °C beam bending test, rutting tests at 60 and 70 °C, the freeze–thaw splitting test, and the single-axis compression dynamic modulus test. To ensure the effectiveness of the mixture’s on-site application, this study validated the raw material specifications at the construction site and adjusted the mix design accordingly. Water stability tests were also conducted. Finally, a survey of the mixing plant at the construction site was carried out, establishing the relationship between each bin’s flow rate and speed ratio. The suitable speed for the production of HMM-13 was calculated. The research results indicate that the optimal asphalt-to-aggregate ratio for HMM-13 is 4.2% (with a comprehensive asphalt-to-aggregate ratio of 5.2%), and the freeze–thaw splitting strength ratio can reach 84.2%. The dynamic stability is 11,217 cycles/mm at 60 °C and 6167 cycles/mm at 70 °C. The stiffness modulus at −10 °C is 5438 MPa, with a failure strain of 2049 με. At 10 Hz and 15 °C, the dynamic modulus is 15,488 MPa, and at 45 °C, it is 3872 MPa. All these indicators meet the requirements for construction technology and pavement performance.
Pull-Off Strength and Mechanical Energy Dissipation in Adhesive Contacts: Experiments and Simulations
Authors: Lyashenko Iakov A. , Pham Thao H. , Popov Valentin L.
Published: January 2024

This study contributes to the understanding of the adhesive properties in normal contacts, providing valuable information on the influence of various factors on adhesive strength and energy dissipation. The adhesive normal contact between a steel spherical indenter and a soft sheet of elastomer is studied experimentally. The dependencies of contact strength and mechanical energy dissipation in the complete indentation–detachment cycle on the indentation depth, the velocity of the indenter, its radius, thickness, and elastic modulus of the elastomer, the specific work of adhesion, as well as the roughness of the indenter surface, were analyzed. Experimental results are compared with simulations using the boundary element method (BEM), and the reasons leading to discrepancies between experiments and simulations are analyzed. It is shown that over a wide range of experimental parameters, the rate of mechanical energy dissipation can be estimated with sufficient accuracy using a simple empirical relation.
Exploring Controlled Passive Particle Motion Driven by Point Vortices on a Sphere
Authors: Balsa Carlos , Otero-Espinar M. Victoria , Gama Sílvio
Published: January 2024

This work focuses on optimizing the displacement of a passive particle interacting with vortices located on the surface of a sphere. The goal is to minimize the energy expended during the displacement within a fixed time. The modeling of particle dynamics, whether in Cartesian or spherical coordinates, gives rise to alternative formulations of the identical problem. Thanks to these two versions of the same problem, we can assert that the algorithm, employed to transform the optimal control problem into an optimization problem, is effective, as evidenced by the obtained controls. The numerical resolution of these formulations through a direct approach consistently produces optimal solutions, regardless of the selected coordinate system.
Formulation and Optimization of Nanoemulsions Loaded with Gamma−Aminobutyric Acid (GABA) for Dermatological Application: Assessing Skin Permeation and Penetration Enhancement
Authors: Charnvanich Dusadee , Singpanna Kamonwan , Panapisal Vipaporn
Published: January 2024

Gamma−aminobutyric acid (GABA) presents several potential skin benefits, but its water−soluble nature poses challenges for effectively penetrating the skin to produce its effects. This research aimed to improve GABA’s skin penetration and availability by employing a nanoemulsion formulation, both with and without the aid of the penetration enhancer 1,8−cineole. Using a high−pressure homogenizer, an oil−in−water nanoemulsion was created, and its size and distribution were analyzed. The stability of these nanoemulsions was tested under various conditions, revealing their resilience over six months, even at elevated temperatures of 40 °C. In vitro tests on pig skin showed that GABA−loaded nanoemulsions, particularly those without the enhancer, demonstrated a nearly 2.89−fold increase in skin permeation compared to the solution form. Moreover, the addition of the enhancer amplified this effect, resulting in over a 3.37−fold increase in skin permeation compared to the solution. These results emphasize the potential of nanoemulsion formulations as effective tools for enhancing GABA’s skin permeation and availability, potentially expanding its use in dermatological applications. Further exploration and research are necessary to fully exploit GABA’s capabilities in supporting skin health and wellness.
Lattice Damage, Optical and Electrical Properties Induced by H and C Ions Implantation in Nd:YLF Crystals
Authors: Qiao Mei , Wang Tiejun , Liu Yong , Cui Wanling , Wang Xiaoxin , Wang Zhenxing , Li Xin , Xu Shicai
Published: January 2024

Neodymium-doped yttrium fluoride crystal has emerged as one of the most valuable functional materials, and has thus become a research hotspot and shown promising application value in recent years. In this work, utilizing 460 keV H and 6.0 MeV C ions implantation, the damage behavior, lattice structure change, spectral, and electrical characteristics of the Nd:YLF crystal induced by electronic and nuclear energy loss were investigated, utilizing complementary characterization techniques (X-ray diffraction, hardness and elastic (Young’s) modulus, micro-Raman, absorption, fluorescence spectra, and I–V characteristic curve). Thus, the annealing effect on the waveguide properties and the surface damage of the samples was discussed. The fabricated waveguide structure shows potential application in highly sensitive optoelectronic sensors.
Properties of Antiferroelectric Mixtures Differing in the Amount of Added Racemate
Authors: Urbańska Magdalena , Dardas Dorota
Published: January 2024

Novel three-component liquid crystalline mixtures composed of chiral and achiral (racemic) liquid crystalline materials were designed and studied by polarizing optical microscopy, differential scanning calorimetry, and UV–VIS spectroscopy. The compositions of liquid crystalline mixtures were developed based on the composition of a two-component (binary) mixture marked as W-1000 with the following phase sequence: Cr ↔ SmCA* ↔ SmC* ↔ SmA* ↔ Iso. This mixture has an antiferroelectric (SmCA*) phase over a wide temperature range and exhibits a helical pitch inversion in this phase. All newly obtained mixtures occur in a wide temperature range of the SmCA* phase, while the ferroelectric (SmC*) phase and the orthogonal (SmA*) phase occur in a narrow temperature range. The new mixtures also have a very long helical pitch in the antiferroelectric phase and a short helical pitch in the ferroelectric phase.
Fabrication and Properties for Thermal Neutron Detection of 6LiCl/Rb2CeCl5 Eutectic Scintillator
Authors: Sasaki Rei , Kamada Kei , Yoshino Masao , Kim Kyoung Jin , Murakami Rikito , Horiai Takahiko , Yamaji Akihiro , Kurosawa Shunsuke , Yokota Yuui , Sato Hiroki , Ohashi Yuji , Hanada Takashi , Yoshikawa Akira
Published: January 2024

The 3He gas is commonly used for the detection of thermal neutrons. However, with the depletion of 3He gas, there is a need to develop new solid scintillators for thermal neutron detection. Solid scintillators containing 6Li, which have large neutron capture cross-sections and a large amount of energy released by transmutation reactions, are commonly used as alternative candidates. However, only single-crystal scintillators are currently used, and their 6Li concentration is limited by their chemical composition. In this study, we designed, grew, and evaluated a new eutectic scintillator, Rb2CeCl5/LiCl, which can improve the 6Li concentration compared with single-crystal scintillators. Rb2CeCl5, which was selected as the scintillator phase, has excellent scintillator properties (light yield: 36,000 photons/MeV, decay time: mostly 24 ns, slightly 153 ns), and is less deliquescent than other halide scintillators. The crystal grown using the vertical Bridgman method exhibited a eutectic phase composed of Rb2CeCl5 and LiCl. The eutectic crystals exhibited Ce3+ 5d-4f emissions, with a peak between 360 and 370 nm. The Rb2CeCl5 phase was identified as the luminescent phase via cathodoluminescence mapping, and 16,000 photons/neutron of the light yield and 56.1 ns of the decay time were observed. This study indicates that the Rb2CeCl5/LiCl eutectic scintillator is a promising candidate for use in thermal neutron detectors.
Self-Consistent Explanation of the Untwist Alignment of Ferroelectric Nematic Liquid Crystals with Decreasing Cell Thickness and Deviation of the Surface Easy Axis Experimented upon Using the Brewster Angle Reflection Method
Authors: Abe Sakunosuke , Shibata Yosei , Kimura Munehiro , Akahane Tadashi
Published: January 2024

The huge dielectric constant of ferroelectric nematic liquid crystals (FNLCs) seems to bring about a difficulty of molecular alignment control in exchange for a potential device application. To obtain a satisfactory level of uniform molecular alignment, it is essential to understand how the molecules near the alignment surface are anchored. In this study, bulk molecular alignment with an anti-parallel rubbing manner, which has not yet been investigated extensively, is explained using a conventional torque balance model introducing a polar anchoring function, and it is shown that the disappearance of the bulk twist alignment with decreasing cell thickness can be explained self-consistently. To validate this estimation for a room-temperature FNLC substance, the Brewster angle reflection method was attempted to confirm the surface director’s deviation from the rubbing direction caused by the polar surface anchoring.
New Prospects on Neuroimaging in Von Hippel Lindau Disease—A Narrative Review
Authors: Pietrzak Nikodem , Jankowska Katarzyna , Rosiak Oskar , Konopka Wieslaw
Published: January 2024

(1) Background: Hemangiomas in Von Hippel-Lindau (VHL) syndrome patients are typically benign but pose threats due to their vital locations involving the central nervous system and the retina. An MRI is currently recommended as the gold standard for tumors associated with VHL in the head region. This narrative review aims to comprehensively outline current standards and recent findings related to imaging of retinal and CNS hemangiomas in Von Hippel-Lindau syndrome. (2) Material and Methods: A review in adherence to PRISMA guidelines using the search string “Von Hippel-Lindau hemangioblastoma imaging” was conducted on PUBMED and SCOPUS databases. (3) Results: After reviewing 455 titles and abstracts, 20 publications fulfilling the inclusion criteria were analyzed. The analysis included studies describing MRI, CT, optical coherence tomography, and PET/CT. (4) Conclusion: While MRI remains the gold standard for diagnosing head tumors in Von Hippel-Lindau syndrome, various PET/CT methods show promise as alternative imaging modalities.
From Severe Anemia to Intestinal Hemangiomatosis, a Bumpy Road—A Case Report and Literature Review
Authors: Vlad Raluca Maria , Dobritoiu Ruxandra , Niculescu Carmen , Moga Andreea , Balanescu Laura , Pacurar Daniela
Published: January 2024

Gastrointestinal hemangiomas (GIH) are unusual vascular tumors found anywhere alongside the GI tract, the small bowel being the most common site. Diagnosis requires good clinical insight and modern imaging. This is a comprehensive review of the literature, starting from a new pediatric case diagnosed through exploratory laparotomy after complex imaging techniques failed. This research was conducted on published articles from the past 25 years. We identified seventeen original papers (two series of cases with three and two patients, respectively, and fifteen case reports). The female/male ratio was 1.5. The youngest patient was a 3-week-old boy, and the was oldest a 17-year-old girl. The most common localization was the jejunum (eight cases), followed by the ileum (four), colon (three), stomach (two), and rectum (one). Seven children had cavernous and four had capillary hemangiomas. Eight patients presented gastrointestinal bleeding, seven had refractory anemia, such as our index patient, three had recurrent abdominal pain, and two had bowel obstruction. Surgical assessment was successful in fifteen cases; three cases experienced great outcomes with oral propranolol, one child was treated successfully with sirolimus, and for one patient, endoscopic treatment was the best choice. The authors present the case of a female patient admitted to the Pediatrics Department of “Grigore Alexandrescu” Emergency Children’s Hospital from 25 February to 28 March 2019 for severe anemia, refractory to oral iron treatment, and recurrent blood infusions. No clear bleeding cause had been found. Although very uncommon, intestinal hemangiomas can express puzzling, life-threatening symptoms. We should keep in mind this disorder in cases of unresponsive chronic anemia.
Generation of JC Polyoma Pseudovirus for High-Throughput Measurement of Neutralizing Antibodies
Authors: Matsuda Mami , Li Tian-Cheng , Nakanishi Akira , Nakamichi Kazuo , Saito Makoto , Suzuki Tadaki , Matsuura Tomokazu , Muramatsu Masamichi , Suzuki Tetsuro , Miura Yoshiharu , Suzuki Ryosuke
Published: January 2024

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by reactivation of dormant JC polyomavirus (JCPyV). PML was mainly observed in immunocompromised individuals, such as HIV-positive patients, autoimmune disease patients, and cancer patients. Given that the presence of anti-JCPyV antibodies in serum is a risk indicator for PML development, it is essential to monitor anti-JCPyV antibody levels. In the present study, we established reporter-based single-infection neutralization assays for JCPyV and the genetically similar BK polyoma virus (BKPyV). We then confirmed the lack of cross-reactivity between the two viruses using test sera obtained from mice immunized with plasmids encoding the JCPyV or BKPyV capsid. Next, we compared neutralization antibody titers in sera from healthy donors, patients with multiple sclerosis (MS), and HIV-positive patients using an in-house enzyme-linked immunosorbent assay (ELISA) with JCPyV-like particles (virus-like particles; VLPs). A positive correlation was demonstrated between the neutralization titer (75% infectious concentration; IC75) against JCPyV and the antibody titer obtained by VLP-based JCPyV ELISA. This assay system may be applied to detect antibodies against other PyVs by generation of pseudoviruses using the respective capsid expression plasmids, and is expected to contribute to the surveillance of PyV as well as basic research on these viruses.
Exome Sequencing Reveals Biallelic Mutations in MBTPS1 Gene in a Girl with a Very Rare Skeletal Dysplasia
Authors: Raggio Víctor , Rodríguez Soledad , Feder Sandra , Gueçaimburú Rosario , Spangenberg Lucía
Published: January 2024

The Kondo-Fu type of spondyloepiphyseal dysplasia (SEDKF) is a rare skeletal dysplasia caused by homozygous or compound heterozygous mutations in the MBTPS1 gene. The MBTPS1 gene encodes a protein that is involved in the regulation of cholesterol and fatty acid metabolism. Mutations in MBTPS1 can lead to reduced levels of these lipids, which can have a number of effects on development, including skeletal anomalies, growth retardation, and elevated levels of blood lysosomal enzymes. This work reports the case of a 5-year-old girl with SEDKF. The patient had a severely short stature and a number of skeletal anomalies, including kyphosis, pectus carinatum, and reduced bone mineral density. She also had early onset cataracts and inguinal hernias. Genetic testing revealed two novel compound heterozygous variants in the MBTPS1 gene. These variants are predicted to disrupt the function of the MBTPS1 protein, which is consistent with the patient’s clinical presentation. This case report adds to the growing body of evidence that mutations in the MBTPS1 gene are causal of SEDKF. We summarized the features of previous reported cases (with age ranges from 4 to 24 years) and identified that 80% had low stature, 70% low weight, 80% had bilateral cataracts and 70% showed Spondyloepiphyseal dysplasia on X-rays. The findings of this study suggest that SEDKF is a clinically heterogeneous disorder that can present with a variety of features. Further studies are needed to better understand the underlying mechanisms of SEDKF and to develop more effective treatments.
Health Checks for People with Down Syndrome: A Pooled Analysis of Three Randomized Controlled Trials
Authors: Ware Robert S. , Franklin Catherine , McPherson Lyn , Lennox Nicholas G.
Published: January 2024

Health checks have beneficial effects on health outcomes in adults with intellectual disability; however, little is known about their effect on people with Down syndrome. The aim of this study was to assess the effect of receiving a health check on the unmet health needs of people with Down syndrome. A pooled analysis of three randomized trials conducted by the same Australian research team was undertaken. The trials used the same tools but differed by participant source (adults in 24 h supported accommodation, adults in private dwellings, adolescents living with parents). The intervention was a one-off health check, and the comparator was usual care. Among 216 participants, health actions were more likely to occur for those allocated to receive health checks, including increased hearing (odds ratio = 4.4; 95% confidence interval: 1.2, 16.4), vision (2.7; 1.1, 6.7), and thyroid (2.3; 1.3, 4.2) testing, and weight recording (4.7; 2.5, 8.8). Health checks conducted at the primary-care level produced substantially increased attention to the health needs of people with Down syndrome.
A Systematic Review of Industry 4.0 Technology on Workforce Employability and Skills: Driving Success Factors and Challenges in South Asia
Authors: Miah Md. Tota , Erdei-Gally Szilvia , Dancs Anita , Fekete-Farkas Mária
Published: January 2024

The purpose of this study is to systematically analyze the impact of Industry 4.0 technologies on workforce employability and skills in the South Asian region. The study investigates the driving success factors, challenges, and needed skills by analyzing 48 peer-reviewed articles. The authors searched keywords on the Web of Science database for articles published between 2013 and 2022. The review was conducted using the preferred reporting items for systematic reviews and meta-analyses (PRISMA 2020) and pareto principles. The analysis identifies nine critical success factors, such as artificial intelligence, digital skills, and big data analytics, that contribute to Industry 4.0’s productivity and efficiency. It also identifies six types of challenges, such as training and development, financial constraints, and regulatory issues that must be addressed to grab maximum potential. In addition, the research categorizes five different skills, including the technical, digital, and social skills that are essential for the evolving labor market. The proposed “Industry 4.0 SEI Framework” provides stakeholders with a comprehensive view of the dynamics of Industry 4.0, thereby facilitating policy and industry strategies.
Assessment of the Perceived Mastery of Interdisciplinary Competences of Students in Education Degree Programmes
Authors: Rodríguez-Torres Ángel-Freddy , Garduño-Durán Jorge , Carbajal-García Sandra-Elizabeth , Marín-Marín José-Antonio
Published: January 2024

The importance of fostering interdisciplinary competences in students acquires a relevant value in the skills that must be developed throughout university studies. These enable them to tackle complex problems and apply knowledge in different contexts, promoting the construction of knowledge through the integration of different disciplines and collaboration between areas of knowledge. The study aims to analyse how university education students perceive their interdisciplinary competences, identifying areas where they feel more confident and those in which they need to improve, with consideration of gender differences and a possible measurement model. The study involves 1066 students from university education courses in Ecuador. The main results highlight the importance of strengthening training in interdisciplinary skills for future teachers, especially in reflective behaviour and the integration of knowledge from different disciplines to address complex problems. It also points to the need to promote interdisciplinary work in higher education and recognises that gender may influence students’ interdisciplinary perceptions and skills. Confirmatory factor analysis supports the validity of the model for measuring these competences.
Comparison of Different Electrochemical Methodologies for Electrode Reactions: A Case Study of Paracetamol
Authors: Masood Zaheer , Muhammad Haji , Tahiri Iftikhar Ahmed
Published: January 2024

Understanding electrochemical reactions at the surface of electrodes requires the accurate calculation of key parameters—the transfer coefficient (α), diffusion coefficient (D0), and heterogeneous electron transfer rate constant (k0). The choice of method to calculate these parameters requires careful consideration based on the nature of the electrochemical reaction. In this study, we conducted the cyclic voltammetry of paracetamol to calculate the values of these parameters using different methods and present a comparative analysis. Our results demonstrate that the Ep − Ep/2 equation for α and the modified Randles–Ševčík equation for D0 is particularly effective for the calculations of these two parameters. The Kochi and Gileadi methods are reliable alternatives for the calculation of k0. Nicholson and Shain’s method using the equation k0 = Ψ(πnD0Fν/RT)1/2 gives the overestimated values of k0. However, the value of k0 calculated using the plot of ν−1/2 versus Ψ (from the Nicholson and Shain equation, where ν is scan rate) agrees well with the values calculated from the Kochi and Gilaedi methods. This study not only identifies optimal methodologies for quasi-reversible reactions but also contributes to a deeper understanding of electrochemical reactions involving complex electron transfer and coupled chemical reactions, which can be broadly applicable in various electrochemical studies.
Nanogranular Strontium Ferromolybdate/Strontium Molybdate Ceramics—A Magnetic Material Possessing a Natural Core-Shell Structure
Authors: Suchaneck Gunnar , Artiukh Evgenii , Kalanda Nikolay , Yarmolich Marta , Gerlach Gerald
Published: January 2024

In this work, we demonstrate the preparation of easy-to-fabricate nanogranular strontium ferromolybdate/strontium molybdate core-shell ceramics and examine their properties, including tunnel magnetoresistance, magnetic field sensitivity, and temperature coefficient of the tunnel magnetoresistance. The tunnel magnetoresistance of nanogranular strontium ferromolybdate/strontium molybdate core-shell ceramics was modeled, yielding values suitable for magnetoresistive sensor applications. Such structures possess a narrow peak of magnetic flux sensibility located at about 80 mT. For magnetic flux measurement, single-domain granules with superparamagnetic behavior should be applied. The predicted TMR magnetic flux sensitivities for granules with superparamagnetic behavior amount to about 7.7% T−1 and 1.5% T−1 for granule sizes of 3 nm and 5 nm, respectively. A drawback of the tunnel magnetoresistance of such nanogranular core-shell ceramics is the unacceptably large value of the temperature coefficient. Acceptable values, lower than 2% K−1, are obtained only at low temperatures (less than 100 K) or large magnetic flux densities (exceeding 6 T). Therefore, a Wheatstone bridge configuration should be adopted for magnetoresistive sensor design to compensate for the effect of temperature.
A High ENOB 14-Bit ADC without Calibration
Authors: Laoudias Costas , Souliotis George , Plessas Fotis
Published: January 2024

This paper presents an implementation of a 14-bit 2.5 MS/s differential Successive-Approximation-Register (SAR) analog-to-digital converter (ADC) to be used for sensing multiple analog input signals. A differential binary-weighted with split capacitance charge-redistribution capacitive digital-to-analog converter (CDAC) utilizing the conventional switching technique is designed, without using any calibration mechanism for fast power-on operation. The CDAC capacitor unit has been optimized for improved linearity without calibration technique. The SAR ADC has a differential input range 3.6 Vpp, with a SNDR of 80.45 dB, ENOB of 13.07, SFDR of 87.16 dB and dissipates an average power of 0.8 mW, while operating at 2.5 V/1 V for analog/digital power supply. The INL and DNL is +0.22/−0.34 LSB and +0.42/−0.3 LSB, respectively. A prototype ADC has been fabricated in a conventional CMOS 65 nm technology process.
Explaining the Behaviour of Reinforcement Learning Agents in a Multi-Agent Cooperative Environment Using Policy Graphs
Authors: Domenech i Vila Marc , Gnatyshak Dmitry , Tormos Adrian , Gimenez-Abalos Victor , Alvarez-Napagao Sergio
Published: January 2024

The adoption of algorithms based on Artificial Intelligence (AI) has been rapidly increasing during the last few years. However, some aspects of AI techniques are under heavy scrutiny. For instance, in many use cases, it is not clear whether the decisions of an algorithm are well informed and conforming to human understanding. Having ways to address these concerns is crucial in many domains, especially whenever humans and intelligent (physical or virtual) agents must cooperate in a shared environment. In this paper, we apply an explainability method based on the creation of a Policy Graph (PG) based on discrete predicates that represent and explain a trained agent’s behaviour in a multi-agent cooperative environment. We show that from these policy graphs, policies for surrogate interpretable agents can be automatically generated. These policies can be used to measure the reliability of the explanations enabled by the PGs through a fair behavioural comparison between the original opaque agent and the surrogate one. The contributions of this paper represent the first use case of policy graphs in the context of explaining agent behaviour in cooperative multi-agent scenarios and present experimental results that sets this kind of scenario apart from previous implementations in single-agent scenarios: when requiring cooperative behaviour, predicates that allow representing observations about the other agents are crucial to replicate the opaque agent’s behaviour and increase the reliability of explanations.
A Distributed Scheme for the Taxi Cruising Route Recommendation Problem Using a Graph Neural Network
Authors: Li Ying , Huang Yongsheng , Liu Zhipeng , Zhang Bin
Published: January 2024

Despite considerable research efforts being devoted to the taxi cruising route recommendation (TCRR) problem, existing studies still have some shortcomings. To begin with, the competition and collaboration between taxis are not sufficiently taken into account. Furthermore, the TCRR is heavily reliant on potential taxi demand, which is time-variant and difficult to accurately predict due to the underlying spatiotemporal correlation and dynamic traffic patterns. Moreover, the consideration of competition and cooperation among taxis increases the complexity of the TCRR problem, making conventional centralized algorithms computationally expensive. In this paper, we first formulate TCRR as a biobjective optimization problem to balance the collaboration and competition between taxis. Subsequently, we forecast short-term taxi demand using the proposed long-short-term-memory-based graph convolutional network (LSTM-GCN), which considers diverse factors such as road topology, points of interest (POIs), and multiple time-scale features. Lastly, we propose a distributed algorithm based on a Lagrange dual decomposition. The experimental and simulation results demonstrate that our TCRR scheme performs better than any other counterpart, (i) resulting in a 3% reduction in idle taxis per hour, (ii) performing four times faster than the centralized algorithms to obtain the optimal solution, and (iii) resulting in a 7% increase in average profit.
Adjacent-Channel Compatibility Analysis of International Mobile Telecommunications Downlink and Digital Terrestrial Television Broadcasting Reception in the 470–694 MHz Frequency Band Using Monte Carlo Simulation
Authors: Taha Hussein , Vári Péter , Nagy Szilvia
Published: January 2024

This paper delves into the imperative need for coexistence and compatibility in the 470–694 MHz frequency band, as mandated by the World Radiocommunication Conference 2015 (WRC-15) and the WRC-23. It focuses on challenges in the coexistence of Digital Terrestrial Television Broadcasting (DTTB) and International Mobile Telecommunications-2020 (IMT-2020) services in downlink-only mode, particularly in adjacent-channel scenarios. Using Monte Carlo simulations, the study evaluates the probability of interference from IMT base stations with DTTB reception. The analysis thoroughly investigates the impact of the IMT transmitter’s Adjacent Channel Leakage Ratio (ACLR) and the DTTB receiver’s Adjacent-Channel Selectivity (ACS) on the probability of interference. The results demonstrate a significant degradation in the DTTB reception probability at the edge of coverage based on standard assumptions. To address these challenges, this paper provides recommendations for mitigating interference. These include defining enhanced ACLR regulations for IMT base stations, implementing antenna discriminations, providing specialized filters, and establishing national coordination procedures. The research provides valuable insights for informed decision making in spectrum management within the 470–694 MHz band, aiming to facilitate the coexistence of DTTB and IMT-2020 services, in line with international regulations and best practices.
Correction: Wu et al. A Universal Accelerated Coprocessor for Object Detection Based on RISC-V. Electronics 2023, 12, 475
Authors: Wu Dongyan , Liu Yuzhou , Tao Chongben
Published: January 2024

In the original publication [...]