bluuebunny/crossref_metadata_2025 huggingface dataset:
Impatiens pseudolenta (Balsaminaceae), A new species from southern part of Western Ghats, India
Authors: C Satheshkumar , Kumari Diksha , Kaimal Ujwala , KM Dr. Prabhukumar , Rana Tikam Singh
Published: March 2024

The genus Impatiens Linnaeus (1753: 937) belongs to the family
Balsaminaceae and comprises of about 1107 accepted species all over the
world (POWO 2024). The genus is mainly distributed to south-east Asia,
tropical Africa and Madagascar (Yu 2012). In India, the genus Impatiens
consists of 340 taxa (314 species and 26 varieties/subspecies), mainly
distributed in the Eastern Himalayas, the neighbouring North-Eastern
states and the Western Ghats (Prabhukumar et al. 2022, Borah et al.
2022, Richard & Ravichandran, 2023, Khanal et al. 2023, Tiwari 2023).
Boycott and Buycott Intent to Actions: Unpacking the Role of Political Ideology and Advertising through The Society of the Spectacle
Authors: Flecha-Ortiz Jose , Rivera-Guevarez Rolando , Santos-Corrada Maria , Fonseca-Rodriguez Maria
Published: March 2024

This study investigates the interaction between political ideology and
consumer behavior regarding the intentions and actions of boycotts and
buycotts. Using a quantitative approach with 408 surveys analyzed using
PLS-SEM and focusing on Society of Spectacle Theory, we examined how
communicative tactics and media representations, particularly in
advertising, affect consumer intentions and actions. This analysis
focuses on Puerto Rico, a unique context in which micro ideologies
significantly influence consumer decisions. These results contribute to
the understanding of the role of political ideology in brand activism,
highlighting how it becomes a consumable image through advertising.
Interestingly, the findings reveal an inclination of Puerto Rican
consumers toward buycotts rather than boycotts, contrasting with global
trends that favor more boycotts, explained by political polarization.
This research fills a significant gap in studies on the interaction
between political ideology and consumer behavior and offers valuable
insights into how ideological representations in the entertainment
society influence political consumption actions.
Advancing the allergenicity assessment of new proteins using a text mining resource
Authors: Moreno F. Javier , Novoa Jorge , Fernández-Dumont Antonio , Mills E.N. Clare , Pazos Florencio
Published: March 2024

BACKGROUND: With a society increasingly demanding alternative protein
food sources, new strategies for evaluating protein safety issues, such
as their allergenic potential, are needed. Large-scale and systemic
studies on allergenic proteins are hindered by the limited and
non-harmonized clinical information available for these substances in
dedicated databases. A clearly missing key information is that
representing the symptomatology of the allergens, especially given in
terms of standard vocabularies, that would allow connecting with other
biomedical resources to carry out different studies related to human
health. In this work, we have generated the first resource with a
comprehensive annotation of allergens’ symptomatology, using a
text-mining approach that extracts significant co-mentions between these
entities from the scientific literature. METHODS: The main resource of
biomedical literature (PubMed, ~36 million abstracts)
was mined to automatically extract relationships between allergens and
clinical symptoms. The annotations are given in terms of standard
vocabularies in widely used biomedical databases. The method identifies
statistically significant co-mentions between the textual descriptions
of the two types of entities in the literature as indication of
relationship. RESULTS: 1,180 clinical signs extracted from the Human
Phenotype Ontology (HPO), the Medical Subject Heading (MeSH) terms of
PubMed together with other allergen-specific symptoms, were linked to
1,036 unique allergens annotated in the two main allergen-related public
databases via 14,009 relationships. CONCLUSIONS: This resource could
serve as a starting point for a future manually curated compilation of
allergen symptomatology. The annotations are publicly available through
an interactive web interface at
[https://csbg.cnb.csic.es/CoMent_allergen/](https://csbg.cnb.csic.es/CoMent_allergen/).
Two cases of AMeD syndrome with isochromosome 1q treated with allogeneic stem cell transplantation
Authors: Kagajo Mari , Moritani Kyoko , Iwamoto Mayumi , Miyamoto Machiko , Imai Tsuyoshi , Motoharu Hamada , Wakamatsu Manabu , Muramatsu Hideki , Eguchi-Ishimae Minenori , Eguchi Mariko
Published: March 2024

AMeD syndrome is characterized by aplastic anemia, mental retardation,
short stature, and microcephaly and is caused by digenic mutations in
the aldehyde dehydrogenase 2 ( ALDH2) and alcohol dehydrogenase 5
( ADH5) genes. We have successfully performed hematopoietic stem
cell transplantation in two patients with AMeD syndrome and
isochromosome 1q. AMeD syndrome with myelodysplastic syndrome or acute
myeloblastic leukemia generally has a poor prognosis; however, early
diagnosis may improve treatment response. Although the gain of 1q has
been considered as a form of early clonal evolution in Fanconi anemia,
it may be an equally important finding observed in AMeD syndrome.
The Utility of Respiratory Rate Index in High-Flow Nasal Cannula Oxygen Therapy for COVID-19 Pneumonia
Authors: Wang Kai , Zhu Jihong , Gao Weibo , Ma Li , Cao Baoping , Fu Xueying , Shi Miao
Published: March 2024

A useful solution for the management of COVID-19 pneumonia has been
identified: oxygen therapy delivered using a high-flow nasal cannula
(HFNC). Improved oxygenation and respiratory support are provided by
this treatment. In patients who are being associated with HFNC for
COVID-19 pandemic, this investigation aims to define whether or not the
respiratory rate index (RRI) is useful as an early indicator of how well
the treatment is working and how the patient would fare clinically. This
study retrospectively examines COVID-19 pneumonia patients maintained
with HFNC in a clinical setting. Data on respiratory rate (RR) was used
to calculate a respiratory rate index that considered both rate and
pattern. Fast respiratory rate index reductions during the first therapy
improved oxygenation and reduced mechanical ventilation. The score
predicted pharmaceutical responsiveness before other clinical markers
made meaningful improvements. RR, OSIXR, and ROX index are questionable
ventilator prevention strategies. We treated 128 COVID-19 respiratory
failure patients who needed oxygen. A 64 HFNC-treated patients were
retrospectively studied. The HFNC group was those who converted from the
HFNC therapy to conventional oxygen therapy (COT), while the COT
treatment was those who converted from the HFNC group to Non-invasive
ventilation (NIV). HFNC patients were successful (24 of 64 (62%)). HFNC
success had a considerably greater univariate RR improvement than COT.
Logistic regression analysis (LRA) adjusted for respiratory development,
age, and ROX index >6.66 showed that an enhanced RR
predicted success. HFNC achievement groups had significantly lower COT
durations than COT groups.
Enhanced synthesis of S-adenosyl-L-methionine through Combinatorial metabolic engineering and Bayesian optimization in Saccharomyces cerevisiae
Authors: Xiao Wenhan , Shi Xiangliu , Huang Haowei , Wang Xiaogang , Liang Wenshu , Zhang Xiaomei , Xu Guoqiang , Xu Jianguo , Xu Zhenghong , Shi Jinsong , Liu Fei
Published: March 2024

S-Adenosyl-L-methionine (SAM) is a substrate for many enzyme-catalyzed
reactions and provides methyl groups in numerous biological
methylations, and thus has vast applications in the agriculture and
medical field. Saccharomyces cerevisiae has been engineered as a
platform with significant potential for producing SAM, although the
current production has room for improvement. Thus, a method that
consists of a series of metabolic engineering strategies was established
this study. These strategies included enhancing SAM synthesis,
increasing ATP supply, and down-regulating SAM metabolism and
downregulating competing pathway. After combinatorial metabolic
engineering, Bayesian optimization was conducted on the obtained strain
C262P6 to optimize the fermentation medium. A final yield of 2972.8 mg/L
at 36 h with 29.7% of the L-Met conversion rate in the shake flask was
achieved, which was 26.3 times higher than that of its parent strain and
the highest reported production in the shake flask to date. This paper
establishes a feasible foundation for the construction of SAM-producing
strains using metabolic engineering strategies and demonstrates the
effectiveness of Bayesian optimization in optimizing fermentation medium
to enhance the generation of SAM.
MiR-205-3p Modulates Hepatocellular Carcinoma-Derived Endothelial Cell Progression through suppression of HINT1
Authors: Wang Mengnan , mao qiqi , Xiang Jianqiang , Li Hong
Published: March 2024

Objectives: We investigated the molecular underpinnings of
miR-205-3p in driving the proliferative behavior of endothelial cells
originating from hepatocellular carcinoma (HCC). Methods: In
our study, reverse transcription quantitative PCR analysis identified a
significant upregulation of miR-205-3p in endothelial cells from HCC.
This upregulation was consistently observed across various HCC cell
lines and tissue samples. Further investigation highlighted the
regulatory effect of miR-205-3p on the HINT1 gene. The interaction
between miR-205-3p and the 3’ untranslated region of HINT1 was confirmed
using a dual-luciferase reporter assay. Additionally, experiments
involving MTT assays and flow cytometry demonstrated that
lentivirus-mediated suppression of HINT1 enhanced cellular proliferation
and reduced apoptotic activity in HCC cell models. Results:
This study reveals that miR-205-3p contributes to the progression of
endothelial cells from HCC by targeting and inhibiting HINT1, a tumor
suppressor. Conclusions: This study provides a theoretical
foundation suggesting that miR-205-3p may serve as a viable molecular
target for gene therapy interventions in clinical settings.
How does ski infrastructure change soil erosion processes on hillslope?
Authors: Piątek Dawid , Bernatek-Jakiel Anita
Published: March 2024

Ski tourism’s popularity is driving a rise in the number of ski resorts.
This study aims to present the impact of ski infrastructure on soil
erosion processes on the example from a small catchment in the
Gubałowskie Foothills in southern Poland, where landscape changes before
(since 1879) and after the construction of the ski station (2007) were
presented. The analyses of changes in flow accumulation, slope
morphometry, and drainage ditches were conducted in the test area.
Quantitative analyses were performed using repeated DEMs derived from
LiDAR survey and detailed geodetic measurements, complemented by
geomorphological mapping done in the field. The study has revealed that
the ski infrastructure has not only directly transformed the hillslope
by flattening and constructing escarpments (up to 3 m high) but has also
created alternating patterns of erosion and accumulation. In the test
area, the drainage ditch was poorly designed. It was filled by materials
(0.1–0.5 m), and two new outlets formed. The escarpment of the analyzed
ski run has been diminished by 0.5 m. An alluvial fan (0.1 to 0.22 m
thick) has developed on the flattened surface below the escarpment with
drainage ditch outlets. This fan is eroded by subsurface flow that
creates a piping system. The gully below the alluvial fan has retreated
upslope, accelerated by subsurface erosion. This study enables the
presentation of hillslope adjustments and processes in response to the
new conditions caused by ski infrastructure. Such results may support
more effective land management in regions changed by ski infrastructure.
Design and Optimization of Modular Biorefinery Supply Chain Under Uncertainty
Authors: Luo Yuqing , Ierapetritou Marianthi
Published: March 2024

Biomass supply chain performance is heavily affected by uncertainties
stemming from supply, demand, or unexpected disruptions. Unlike
petrochemical plants that use crude oil, biorefineries often have to
deal with the uneven spatial-temporal distribution of feedstock supply.
The modular production strategy provides more flexibility in chemical
manufacturing by allowing fast capacity expansion and unit movement.
However, modeling and optimizing modular biomass supply chain under
uncertainties becomes challenging due to high-dimensionality and the
existence of discrete decisions. This work optimizes the multiperiod
biomass supply chain using the rolling horizon planning and two-stage
stochastic programming framework. We then applied generalized Benders
decomposition to reduce the computational complexity of the stochastic
mixed integer nonlinear programming (MINLP) supply chain optimization.
Furthermore, the solution of the stochastic programming could be used to
quantitatively describe the life-cycle assessment uncertainties of the
biomass supply chain performance, demonstrating seasonality and random
variability.
Gender-based Long-term Outcome for Atrial Fibrillation Patients post Catheter Ablation
Authors: Lin Mingjie , Han Wenqiang , Rong Bing , Zhang Kai , Chen Tongshuai , Wang Juntao , Li Yihan , Chen Changli , Wu Lin , Zhong Jingquan
Published: March 2024

Background Previous research indicates disparities in atrial
fibrillation (AF) recurrence and complications following catheter
ablation in women; however, long-term outcomes based on gender remain
underexplored. Objective This study evaluated the long-term
rates of AF recurrence and major adverse cardiovascular and
cerebrovascular events (MACCE) following catheter ablation,
investigating gender-related risk factors to inform clinical practice
improvement. Methods We conducted a retrospective analysis
using data from a prospectively observational registry of AF ablation
procedures at our institution from 2015 to 2020. Patients were followed
up for MACCE and AF recurrence. The risk factors of AF recurrence and
MACCE were further explored. Results The study cohort consisted
of 2,293 patients, including 1,441 males and 852 females, and had an
average follow-up duration of 50.36 months. After catheter ablation,
females exhibited a notably higher rate of recurrence compared to males,
with a hazard ratio of 1.305 and a 95% confidence interval ranging from
1.101 to 1.547, which was statistically significant (p=0.0014). Gender
differences in AF recurrence persisted regardless of early versus late
intervention (both p<0.05). No significant difference in MACCE
rates was observed between genders. Independent risk factors for AF
recurrence included female gender, diabetes, left atrial diameter ≥40
mm. Conclusions Gender differences significantly impact the
long-term outcomes of AF recurrence, but not MACCE rates post-catheter
ablation. The study highlights the necessity to integrate gender
considerations into AF management strategies.
Patient Directed Basal Electrode Deactivation Is Associated with Diminished Audibility
Authors: Pisa Justyn , Bortoluzzi Tessa , Sulkers Jacob , Hochman Jordan
Published: March 2024

Introduction: Cochlear implantation (CI) has revolutionized
patient care, however speech and audibility outcomes vary between
recipients. This study evaluates post-operative CI performance in
recipients with an intact electrode array compared to a smaller subset
with one or more basal electrodes deactivated to ascertain any
significant differences in speech perception. Methods: A
retrospective review of a single CI centre database (from 2011-2021) in
[BLINDED], using a Mid-Scala electrode, with focus on recipients
identified with one or more deactivated basal electrodes was performed.
Comparisons between conventional users and the deactivated cohort
included aided pure tone testing in sound field and open-set sentence
recognition scores (AzBio) at one-year post activation. Subjective
measures were collected to assess overall satisfaction with devices.
Results: 48 individuals out of 167 adult recipients had
selected for deactivation of basal electrodes. Reasons for deactivation
included sound quality and lack of sound percept. There were no
significant differences in pre-operative status or demographics between
the two cohorts. T-Test analysis found significant differences in aided
thresholds between the “intact” and “deactivated” electrode cohorts
at 4KHz and 6KHz (p <0.01). Mean post-operative speech
perception was also significantly worse in the “deactivated” cohort
(48.5% compared to 59.0%) at 1-year post activation
(p<0.01). There were no significant differences found between
groups in overall satisfaction with their CI. Conclusion:
Patient request for basal electrode deactivation owing to subjective
sound quality illustrates decreased audibility and speech perception,
however CI satisfaction is preserved.
ERP biomarkers for go/no-go tasks to detect potential cognitive impairment in community-dwelling older adults
Authors: Kimura Naotoshi , Hirano Daisuke , Yano Hana , Taniguchi Keita , Taniguchi Takamichi
Published: March 2024

With an aging population, detecting cognitive dysfunction at an early
stage is important. However, no current neurophysiological assessments
examine brain activity status in community-dwelling older adults.
Therefore, this study aimed to determine the relationship between
event-related potential (ERP) and neuropsychological scores during
go/no-go tasks among community-dwelling older adults. The participants
were 34 young adults and 46 older adults. They underwent a go/no-go task
to measure ERP, and older adults also underwent neuropsychological
testing. Older adults were divided into two groups for analysis based on
the results of the Japanese version of the Montreal Cognitive Assessment
(MoCA-J): cognitively normal and cognitively impaired. N2 latency was
significantly delayed in the cognitively impaired group compared to the
cognitively normal and younger groups. In addition, the younger group
exhibited a significant increase in P3 amplitude and faster latency
compared to both older adults groups, with no notable difference between
the two older adult groups. Results of a correlation analysis between
ERP and neuropsychological test scores showed that the N2 latency was
correlated with neuropsychological test scores, which suggested that
receiver operating characteristic (ROC) curve analysis could
discriminate cognitive function. These results indicated that the N2
latency reflected potential cognitive dysfunction in community-dwelling
older adults. Furthermore, P3 amplitude may be useful in detecting
age-related decline in inhibitory function.
Assessment of Antibody Levels and Vaccine-Induced Serological Responses after completion of cancer treatment in Pediatric Patients: A Six-Year Experience in Turkey on HAV, HBV, VZV, and MMR Vaccinations
Authors: Gundesli Sebiha Sukran , Celik Melda , YALÇIN Sıddıka Songül , Aydın Burca , Kurucu Nilgun , Yalcin Bilgehan , Varan Ali , Kutluk Tezer
Published: March 2024

Objective: Cancer treatment in children leads to failure to
complete the childhood vaccination program and weakening or loss of
vaccine-acquired immunity. Post-treatment vaccine responses of children
receiving cancer treatment vary. In this study, we aimed to investigate
serum antibody status, and vaccine responses in children after cancer
treatment. Methods: Pediatric patients who were admitted to
Hacettepe University Hospitals between January 1, 2015, and December 31,
2020, who received chemotherapy for lymphoma and solid organ tumors, and
whose diseases were in remission were included in the study. Vaccines
administered after cancer treatment, hepatitis A (HAV), hepatitis B
(HBV), varicella zoster (VZV), measles-mumps-rubella (MMR) serum
antibody levels, and changes in vaccine responses after treatment were
retrospectively investigated. Results: The study included 533
patients. After treatment, measles, HAV, rubella, HBV, VZV, and mumps,
seronegativity were found in 83.5%, 64%, 60.1%48,5%, 43.3%, and
28%of the patients, respectively. Post-treatment rates of antibody loss
in descending order were measles (47.1%), HAV (31.9%), HBV (31.4%),
mumps (28.6%), VZV (21.7%), and rubella (11.4%). Seroconversion rates
to one dose of vaccines in descending order, were (83.6%), rubella
(82.9%), HBV (81.4%), VZV (63.5%), mumps (45.4%), and measles
(33.3%). Seroconversion rates to two doses of the same vaccines, in
descending order, were: HAV (98.8%), VZV (84.6%), rubella (80%), HBV
(80%), measles (32.2%), and mumps (36.2%) Conclusion:
Serologic vaccine responses of patients after treatment were lower than
expected even with repeated doses. As these patients may require
intermittent serologic evaluations and repeated vaccinations according
to their risk status, we have planned longer-term follow-ups of them.
Mössbauer study of iron oxide nanoparticles
Authors: Sarafidis C. , Karra C.
Published: March 2024

Magnetic nanoparticles have recently attracted attention for biochemical
and medical applications like drug delivery and hyperthermia for a
variety of reasons with most important being their stability, chemical
compatibility, and suitable magnetic properties like moderate specific
mass magnetization. Cobalt ferrites are a well-studied family of
materials and the partial substitution of Fe
cations by rare earth (RE) ones may be used to tune the magnetic
properties. In the present work pure and substituted Co ferrite
nanoparticles with nominal stoichiometry CoFe R
O (R = Yb, Gd; x = 0.05, 0.1,
0.3) synthesized by the co-precipitation method are studied with
Fe Mössbauer spectroscopy in order to determine the
incorporation of RE ions in the spinel lattice. The fitting procedure
was based on the standard spinel model using two sextets for the
octahedral and the tetrahedral coordinated positions of Fe atoms. All
isomer shift values were found within the typical range of high spin
ferric ions while quadrupole splitting values strongly suggest that
there is a substitution preference; RE ions replace iron ones in
octahedral sites. The inversion parameter was found to decrease with RE
content (lowest value about 0.534 for CoFe Yb
O ) and thermal treatment always
results in changing the material towards normal spinel, while pure CoFe
O was inverse. Thermal treatment of
substituted materials in ambient air at temperature range 1500-1700 K
for 12 hours increase crystallite size and changes the degree of
inversion.
Real world use of Tixagevimab/Cilgavimab pre-exposure prophylaxis of COVID-19 in immunocompromised individuals: data from the OCTOPUS study.
Authors: Vergori Alessandra , Matusali Giulia , Cimini Eleonora , Bordi Licia , Borrelli Paola , Lanini Simone , Palazzi Roberta , Paulicelli Jessica , Mariotti Davide , Mazzotta Valentina , Notari Stefania , Casetti R. , Francalancia Massimo , Rosati Silvia , D’Abramo Alessandra , Mija Cosmina , Mencarini Paola , Milozzi Eugenia , E Caraffa , Sica Simona , Metafuni Elisabetta , Sorà Federica , Rago Angela , Siniscalchi Agostina , Abruzzese Elisabetta , Garzia Mariagrazia , Luzi Giovanni , Battistini Roberta , Prosperini Luca , Cingolani Antonella , Girardi Enrico , Maggi Fabrizio , Antinori Andrea
Published: March 2024

We report real world use over time in immunocompromised subjects
receiving tixagevimab/cilgavimab (T/C) pre-exposure prophylaxis (PrEP).
Observational study on participants receiving T/C PrEP stratified: never
had COVID-19 (NoC), hybrids (H) and breakthrough infections (BTIs) if
COVID-19 before or after PrEP, respectively. Anti-RBD IgG and BA.5
neutralizing antibodies (nAbs), mucosal IgG, T-cell immunity at the
administration of T/C (T0), 3 (T1), 6 (T2), and 9 (T3) months after,
were measured. Comparison of markers in each group across timepoints,
Poisson regression model for BTIs incidence rate ratios were performed.
N=231 participants: median age 63 years (IQR 54.0-73.0), 84%
hematological disease, median vaccine dose of three. N=72 NoC, 103 H and
56 (24%) BTIs, mostly mild/moderate, IR 4.2 (95%CI 3.2-5.4) BTIs/100
patients-months, no factors associated with. A significant increase of
anti-RBD IgG at T1 was observed in all the groups, with a decline at T2.
GMTs of anti-BA.5 nAbs were low at T1 for all the groups and
around/below the cut off. No changes of IFN-γ. Overall, a mucosal
response was observed at T1. An incidence of 24% of mild/moderate BTIs
was observed. Anti-RBD IgG levels persistence was ensured, BA.5 nAbs
were low/undetectable, cellular T immunity remained stable.
Self-positivity bias and/or other-negativity bias? A comprehensive examination of the ERP correlates of self- and other-referential processing in early adolescence
Authors: Liu Pan , Tan Jaron
Published: March 2024

Self-referential information is uniquely salient and preferentially
processed even in children. The literature has used the Self-Referent
Encoding Task (SRET) combined with ERPs to study the neural substrates
of self-referential processing and its role in development. However, no
work has implemented a data-driven, comprehensive examination of the ERP
correlates of SRET in youths by comparing a self-referential condition
with an other-referential condition. Ninety-two 10-to-14-year-old
typically developing youths completed an ERP version of the SRET
consisting of a self-referential and an other-referential condition,
following which they were unexpectedly asked to complete a recognition
task of the presented words. A data-driven Principal Components Analysis
isolated five SRET-elicited ERPs: P1, P2, N400, and anterior and
posterior late positive potential (aLPP, pLPP). Two-way ANOVAs (Referent
× Valence) demonstrated a “self-positivity” bias in aLPP, recognition,
and memory sensitivity: youths showed an enhanced aLPP, better
recognition, and higher memory sensitivity for Self-Positive versus
Self-Negative words, whereas no such differences were found between
Other-Positive and Other-negative words. Further, a (marginal)
“other-negativity” bias was found in pLPP, P2, and recognition: youths
displayed an enhanced pLPP and P2 and higher memory sensitivity in the
Other-Negative versus Other-Positive condition, whereas no such pattern
was observed in the Self conditions. We provided novel evidence on a
self-positivity bias that uniquely favored positive self-referential
words as well as an other-negativity bias that uniquely favored negative
other-referential words. These findings contribute to our mechanistic
knowledge of self-referential processing in youths and inform future
studies on the role of self-referential processing in socioemotional
development.
Reindeer grazing inhibits climate-driven biodiversity in the Fennoscandian tundra
Authors: Ramirez Juan Ignacio , Sundqvist Maya , Lindén Elin , Björk Robert , Forbes Bruce , Suominen Otso , Tyler Torbjörn , Virtanen Risto , Olofsson Johan
Published: March 2024

Herbivores in the tundra interact with vegetation through several
mechanisms, especially defoliation, trampling and nutrient addition
through urine and faeces. Through these mechanisms, herbivores drive
shifts in plant species composition, richness and diversity. As reindeer
effects on vegetation accumulate over time, they might cascade to other
trophic levels, but how and when this happens is poorly understood.
Since it is methodologically demanding to measure biodiversity across
spatial gradients, an alternative approach is to assess it indirectly
via biodiversity indices of vascular plants. Values from the Index of
Biodiversity Relevance were coupled with vegetation data from a network
of 96 fenced and paired grazed plots across Fennoscandia. We analysed
the role herbivory has on plant richness and diversity, and on the
number of organisms that depend on the vegetation according to the index
values. We also explored how herbivores affect the competitive effects
of shrubs on other plants since the dominance of a vegetation type links
directly to biodiversity. Vegetation richness and diversity did not
present any differences between treatments, yet reindeer had an
increasing effect on plant diversity when testing the interaction
between grazing and herbaceous vegetation. Three out of six biodiversity
indexes were higher in fenced plots indicating a higher number of
interactions between plants and organisms from other trophic levels.
Finally, herb abundance was negatively related to shrubs in both
treatments but with a faster decline in the absence of herbivores,
suggesting that herbivory increases plant diversity and decreases the
diversity of other taxa by reducing shrub abundance. This study
highlights the importance of maintaining herbivore populations in the
Arctic to prevent the expansion of climate-driven biodiversity into the
tundra. The effect of herbivores on ecological communities is not merely
a product of plant diversity but can be quantitatively and qualitatively
different.
Mobility Management in LEO Satellite Constellations
Authors: Ansari Saadan , Prinz Richard , Sajatovic Miodrag , Acar Guray
Published: March 2024

Recently, ESA started the activity “Development of On-board IP
Router Protocol Stacks for Future Satellite Systems”, with the
abbreviated name On-Board Router (OBR), to identify potential of
installing IP routing capabilities on board satellites. This paper
focusses on specific challenges related to efficient IP routing-in-space
and describes several potential solutions identified within the OBR
project.
Combinatorial biomedicine: A novel discipline
Authors: Hu Chunsong
Published: March 2024

Based on the author’s previous work, this article proposed a novel
discipline– combinatorial biomedicine. Currently, there are several
classical examples. One is a magic “polypill” covering the “Health
Essential (HE) 5”, that is, “environment-sleep-emotion-exercise-diet”
intervention [E(e)SEEDi] lifestyle; Another is an innovative
“traditional Chinese medicine (TCM) Hot Pot”. In addition, the
iRT-ABCDEFG program is indeed suitable for better management of human
diseases. In fact, combinatorial biomedicine is pivotal in the
development of life science, biology and medicine, in particular the
pandemic and post-COVID-19 era, and has obvious advantages in screening,
diagnosis, treatments, prevention and rehabilitation of both major
non-communicable diseases (such as cardiovascular disease, diabetes,
cancer, stroke, and neurodegenerative diseases) and major infectious
diseases (such as AIDS, Helicobacter pylori infection, and COVID-19). As
a novel discipline, combinatorial biomedicine plays a crucial role in
combating human diseases and improving population health. It is about
time to propose and establish this novel discipline.
Sweet’s syndrome associated with Pediatric acute myeloid leukemia: A case report and concise review of literature
Authors: Munikoty Vinay , Venkatesh Anirudh , K Vasudeva , MV Archana , Godkhindi Vishwapriya Mahadev , R Ramitha Bhat , Achyutrao Atul , Pai Chandana
Published: March 2024

Sweet’s Syndrome (SS) is an inflammatory skin condition characterised by
sudden onset of fever, painful skin lesions and neutrophilic
infiltration of affected tissues. The systemic association of SS include
infections, drugs, malignancy and autoimmune disorders. The diagnosis
requires prompt clinical suspicion followed by histopathological
confirmation. We describe a case of a 6-year-old boy with relapsed acute
myeloid leukaemia (AML) presenting with the fever and diffuse
erythematous papules over the face, neck, trunk, arms and legs. Early
identification and histological confirmation aided treatment of above
condition. The clinical rarity, diagnostic clues and a brief review of
published literature has been described.
Addressing the evolving outbreak of Mpox disease in the Democratic Republic of Congo: Risk factors, challenges, and recommendations.
Authors: Sibomana Olivier , Ndayambaje Egide
Published: March 2024

Mpox, a zoonotic disease tracing its origins to 1958, has garnered
significant global attention, prompting the World Health Organization
(WHO) to declare the Mpox epidemic a Public Health Emergency of
International Concern (PHEIC) on July 23, 2022—the seventh such
declaration in history. This contagious disease spreads through close
contacts, featuring key symptoms such as fever, chills, headaches,
weariness, asthenia, lymph node swellings, back pain, and myalgia.
Notably, the Democratic Republic of Congo (DRC) stands among the top 10
countries globally grappling with a substantial number of Mpox cases
within the ongoing multi-country outbreak. Between January 1 and
November 12, 2023, a staggering 12,569 suspected Mpox cases, including
581 suspected Mpox-related deaths (with a case fatality ratio of 4.6%),
were documented across 156 health zones in 22 out of 26 provinces in
DRC. This commentary delves into the epidemiology of the Mpox outbreak
in the DRC, explores transmission risk factors, addresses the challenges
in Mpox control, and puts forth insightful recommendations to manage the
Mpox outbreak in DRC and worldwide.
Tax Risks in Enterprise Activity
Authors: Maksimova Natalia
Published: March 2024

W niniejszym artykule zostały omówione takie zagadnienia jak: definicja ryzyka w biznesie, istotne zagrożenia obejmujące przedsiębiorstwa, ryzyko naruszenia prawa podatkowego i ryzyko związane ze skutecznością mechanizmu podatkowego jako całości. Zostały omówione również uogólnione cechy charakterystyczne dla biznesu prowadzonego na Ukrainie. Na podstawie Ordynacji podatkowej określono także rodzaje sankcji stosowanych w przypadku popełnienia przestępstwa podatkowego.
Children, Family, and State: Changing Relationships and Responsibilities
Authors: Fauske Halvor , Bennin Camilla , Buer Bjørn Arne
Published: March 2024

The chapter examines the changing relationships between children, families and the state, and their impact on the Norwegian child welfare services authority. It discusses the evolution of concepts of family and parental rights, providing a historical backdrop of state-family interactions with a focus on children. The importance of the parent-child relationship’s quality and caregiver duties are emphasized, alongside human rights considerations, referencing European Court of Human Rights cases and the Norwegian Child Welfare Act. The chapter underscores the necessity for child welfare services to evaluate the family network, parental competence, relationship quality and child development critically.
Family Ethics and Child Welfare
Authors: Nordby Halvor
Published: March 2024

In modern philosophy, family ethics has developed as a separate field of study. Central questions in family ethics are what a family really is, how parents have a right to decide over their own children and how children have a right to a family. In this chapter, I focus on a well-known version of family ethics, namely Brighouse and Swift’s (2014) influential ‘justification of the family’. If their arguments are plausible, then they have significant implications for how child welfare workers should work with children and their families. The aim of this chapter is to discuss Brighouse and Swift’s position critically, in order to assess the justification of these implications. In a reasonable interpretation of their arguments, they seem to defend a general paternalistic attitude towards children based on the view that children are ‘adults in progress’. But this defence fits poorly with important considerations in the exercise of power in child welfare and a modern view of children as competent actors. A possible strategy to salvage some of the strength of Brighouse and Swift’s arguments would be to argue that the conclusions are meant to be tentative, and that they need to be filled in contextually in practical child welfare work. But the problem is that the conclusions do not even seem reasonable as prima facie guidelines for practice in the complex collaborative relationships child welfare workers are involved in. In the final section, I discuss how the arguments in the chapter affect the philosophical validity of Brighouse and Swift’s views, while also illustrating a general point: some normative principles that may seem reasonable in some contexts of child welfare work may be unjustified in others. The extent to which such principles should guide practice must therefore be considered contextually.
How Parental Relationships Influence Young People’s Identities and Meaning Constructions of Family and Family Life
Authors: Halsa Astrid
Published: March 2024

Even though parental mental illness and substance abuse are considered a serious risk to children’s wellbeing, most children with such parental problems are cared for at home. In the Norwegian Child Welfare Services (CWS), more than 75 per cent of children are supported while living with their parents. In this chapter, we will listen to the voices of young adults on their experiences of growing up with parental mental health problems and or/alcohol and drug issues. The study explores those practices and processes that young adults themselves identified as everyday ways of ‘doing family’ and how these practices helped them ‘get by’ in regard to these challenging experiences in their childhoods. Furthermore, the chapter discusses how parental relationships influence young people’s identities and meaning constructions of family and family life.
Quality and Legitimacy in ECEC Mapping: How Can Mapping Contribute to the Protection of Children and Their Families?
Authors: Midtskogen Bjørg
Published: March 2024

In this chapter I discuss the quality and legitimacy of mapping in Early Childhood Education and Care (ECEC) and how the mapping and cooperation with the parents can be a bridge-builder to the Child Welfare Services (CWS). I use data from my doctoral dissertation on how mapping is included in the pedagogical practice of ECEC assistants and teachers, with a focus on whether and to what extent this process takes children’s perspectives into account (Midtskogen, 2022). Through participatory observation and individual interviews with parents and ECEC employees, I find that there is no standardised mapping with specific quality requirements for ECEC institutions today. It is interesting to discuss the quality and legitimacy of the ECEC institution’s dynamic mapping process because such mapping can have implications for the family’s path to the CWS at an early stage, contribute to the family’s resilience process and prevent dangerous situations for the children. I direct the analyses and interpretation of the findings towards the extent to which the mapping process includes elements that fulfil the requirements of deliberative theory, such as the involvement of affected parties, argumentation, discussion and transparency (Læret & Skivenes, 2016; Oterholm, 2003; Eriksen & Weigård, 1999). Thus, this chapter contributes knowledge about the right to child and family participation in the mapping process in Norwegian ECEC institutions and how the institution’s mapping can be part of a comprehensive developmental process for the family, serving as a bridge to the CWS and other child and family services.
Narrative Identities in Children as Next of Kin. A Qualitative Interview Study
Authors: Söderström Kerstin
Published: March 2024

This chapter explores how childhood and family experiences influence identity and self-understanding. Thirty-two interlocutors from 12 to 32 years old have shared their stories of living in, and growing up in, a troubled family in a conduct-of-everyday-life qualitative interview. All were children as next of kin to parents with substance use disorders and mental health problems. The stories were analysed in terms of self-defining memories and characteristic imagoes.

The interlocutors present themselves mainly as an agentic changemaker, as one being drawn into the parents’ problems, or more or less deliberately distancing themselves from the parents’ problems. At an early age the story is still open, undigested and in the making, as is the narrative identity. The mismatch between the unique family and the cultural norm is seen as a potential resource for self-understanding.
Envisioning Future Elementary School Teachers’ Practices in The Post-Pandemic Era: A Visual Narrative Inquiry
Authors: Mahmud Yogi Saputra
Published: March 2024

The COVID-19 pandemic has revolutionised the educational landscape massively, including the way teachers enact their roles both inside and outside the classroom context. The abrupt changes also influence pre-service teachers’ way of envisioning themselves as future teachers in the post-pandemic era. The aims of this study is to analyze the underlying influences and concerns for their choice of future projection as post-pandemic elementary school teachers. This study using the photo-narrative frame construct of visual narrative inquiry, this study explored the way three first-year pre-service elementary school teachers imagined their. The data were collected from students’ self-portraits and written narratives narrating their past, current, and future projection as post-pandemic teachers. The multimodal narrative analysis was applied to analyse both the visual and written narratives. The findings suggest that technology integration and student-centred pedagogy became the most common themes when the pre-service teachers projected their future selves. At the same time, their previous schooling experiences and future concerns about becoming a teacher had certain impacts on the way they projected themselves as future teachers. Therefore, it is recommended that future pre-service teachers should be given opportunities to reflect on their previous teaching and learning experiences and project what they wish to emulate and enhance for their future teaching practices.
The School Literacy Program: The Parental Role in Improving Literacy Skills on Online Learning of Elementary Students
Authors: Agustri Diana , Suroyo Suroyo , Yuliana Ernik
Published: March 2024

Parents who have a high level of education tend to understand more and think that education is very important for their children, so they prioritize education for their children. In addition, the way to educate children tends to be different between parents who have a high level of education and those with low education. The aim of this study is to analyze the parental role to improve literacy skills on students. This study is qualitative research with the subject is parents of students, moreover the Interview will be the instrument and data collection of this study. However, data collection of this using interview with survey method to get data from participants. However, data triangulation is data analyzing method for this study. The instrument used is a questionnaire. The population is 134 people, using a tolerance level of 5%, it can be seen that the number of samples in this study were 100 parents. The result found that Online learning is inseparable from problems that are obstacles in its literacy skills of elementary students, including online learning for elementary school students such as limited telecommunication networks. It is important to know the barriers for parents to assist their children to improve their literacy skills in online learning, solutions and projections of online learning for elementary school students.in conclusion, role of parents could take responsibility of their children in improving literacy skills through online learning for elementary school.
Multicultural Competence of Elementary Teacher Education Students
Authors: Fatmawati Laila , Prama Dewi Kirana , Wuryandani Wuri
Published: March 2024

Multicultural competence is essential for a country that has diversity, such as Indonesia. At the individual level, multicultural competence helps students appear successful in modern society and achieve personal development to a complete or collective level. People with high multicultural competence can work together to reduce intercultural conflict and build prosperity for all humanity. As elementary teacher candidates, elementary teacher education students are expected to have high multicultural competence. This study aimed to measure the multicultural competence of primary teacher education students. The research method used was a survey by a questionnaire distributed to teacher education students. The data analysis technique used is descriptive statistics. The survey results show that 85 students have very high multicultural competence, 34 students have high multicultural competence, one has medium multicultural competence, and one is very low. Cultural Awareness Competence is 24.57%; understanding of own and others' cultures indicator is 22.52%; Cultural Competence indicator is 24.89%. The Cultural Encounter indicator is 28.02%. It was concluded that elementary teacher education students already have high multicultural competence.
Mathematics Ethnic Learning Program in Improving the Understanding of Mathematical Concepts and the Character of Homeland Love
Authors: Wibowo Sigit , Unik Ambarwati  , Fery Muhamad Firdaus
Published: March 2024

Mathematics learning is still considered abstract and challenging to understand for most elementary school students. This results in students' low understanding of mathematical concepts. This research aims to measure the effectiveness of the "Mathematics Ethnic Learning" program, which has been implemented to increase elementary school students' understanding of mathematical concepts and patriotism. This research uses a quantitative type of research with a one-group pretest-posttest research design and a quasi-experimental method. The sampling technique used is the purposive sampling technique. Data was obtained from a test for understanding mathematical concepts and the results of a Love of the Country character questionnaire. Data analysis used the paired sample t-test and n-gain test. This research shows that students' comprehension test scores and the love of the country character questionnaire before and after the program was implemented showed a significant increase in these two aspects. Based on the statistical analysis that has been carried out, it shows that learning mathematics by applying traditional games can significantly influence students' understanding of the concept and character of patriotism. Furthermore, after being tested using the n-gain score formula, it showed that traditional games were quite effective in increasing understanding of mathematical concepts and the character of loving one's country. It was concluded that Mathematics Ethnic Learning can increase elementary school students' understanding of mathematical concepts and their sense of patriotism.
Increase Interest in Learning Mathematics for 5th Grade Students Using Android Game-Based Learning Media
Authors: Wulan Ningdyah Anggraini
Published: March 2024

This research article is based on observational data that indicates students' learning styles, frequently used instructional media, low math scores of 5th grade students, and students' inability to comprehend the taught materials. The objective of this research is to analyze students' learning interest in mathematics subjects using game-based educational media. The study was conducted in a 5th grade class with a total of 26 students. The research method used was Research and Development (R&D), and the development model employed was the ADDIE development model. The game product was tested by experts and students to assess the validity of the educational game. The results from expert evaluations yielded 92% for subject matter expertise, 94.67% for instructional design expertise, 94.44% for instructional media expertise, 100% for individual testing, and 92.92% for small group testing. The research involved 26 respondents who were 5th grade students in a primary school. The effectiveness test results showed a significant difference between the math scores of 5th grade students before and after using game-based Android instructional media. It can be concluded that game-based Android instructional media can enhance students' learning interest in 5th grade mathematics subjects at the primary school level.