bluuebunny/crossref_metadata_2025 huggingface dataset:
Device-Based Measurement of Office-Based Physical Activity and Sedentary Time: A Systematic Review
Authors: Bongers Noah , Healy Genevieve N. , Thomas George , Clark Bronwyn K.
Published: September 2024

Background: The aim of this study was to systematically review the findings for validity, reliability, and acceptability of device-based measures of office-based physical activity and/or sedentary time in an office context to evaluate workplace interventions. Methods: The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Analysis guidelines. Five electronic databases (PubMed, EMBASE, CINAHL, Cochrane, and Web of Science) were searched (inception to December 2023). Keywords included population (e.g., workers), type of measure (e.g., device-based), measurement constructs (e.g., validity), context (e.g., office), and behavior (e.g., sitting). Two authors screened titles, abstracts, and full texts independently with disagreements resolved by a third author. Findings were reported using narrative synthesis, and COnsensus-based standards for the Selection of health status Measurement INstruments was used for quality assessment. Results: In total, 2,299 articles were identified, with 16 articles retained. These reported 21 measurement protocols (nine in free-living settings) assessing eight worn, four remote, and one combined method. Sixteen protocols assessed office sitting, with standing (n = 8), moving (n = 11), postural transitions (n = 7), and location (n = 2) also assessed. Participant sample sizes ranged from one to 42 (median = 13). Criterion validity was assessed in all 21 protocols, with lower limb–worn measures of sitting, and worn and remote measures of location reporting the highest validity/accuracy compared with the ground truth (good to excellent). Only two articles reported acceptability (good acceptability), with none reporting reliability. Conclusions: There is evidence of valid device-based measures of office behavior (particularly sitting and location of workers), but this has largely been obtained in laboratory settings and/or with small samples. Larger studies in more varied free-living settings, potentially using multiples sources of data and assessing acceptability, are required.
Laser Transfer of Upconversion Nanoparticles
Authors: Zhigarkov V. S. , Yusupov V. I. , Khaydukov E. V.
Published: September 2024

A method of the transfer of NaYF4:Yb3+Tm3+/NaYF4 upconversion core/shell nanoparticles with an average size of 30 nm via laser-induced forward transfer is proposed. The method provides a high spatial resolution by creating a “sandwich” structure on the donor substrate: for reliable fixation, nanoparticles are located between gold layers 50 and 20 nm thick. The transfer of upconversion nanoparticles is implemented by focusing nanosecond laser radiation into a 30-μm-diameter spot and at optimal pulse energies of 8.5–25 μJ. It has been shown that, despite large temperature, $$\Delta T > 1000{\kern 1pt} $$ K, and pressure, $$\Delta P > 150{\kern 1pt} $$ MPa, fluctuations upconversion nanoparticles fully retain their photoluminescent characteristics.
Magnetically targeted lidocaine sustained-release microspheres: optimization, pharmacokinetics, and pharmacodynamic radius of effect
Authors: Zheng Ling-xi , Yu Qian , Peng Lin , Li Qiang
Published: September 2024

Objective

This study aimed to optimize the formulation of magnetically targeted lidocaine microspheres, reduce the microsphere particle size, and increase the drug loading and encapsulation rate of lidocaine. The optimized microspheres were characterized, and their pharmacokinetics and effective radii of action were studied.

Methods

The preparation of magnetically targeted lidocaine microspheres was optimized using ultrasonic emulsification-solvent evaporation. The Box-Behnken design method and response surface method were used for optimization. The optimized microspheres were characterized and tested for their in vitro release. Blood concentrations were analyzed using a non-compartment model, and the main pharmacokinetic parameters (half-life (t1/2), maximum blood concentration, area under the blood concentration-time curve (AUC), time to peak (Tmax), and mean retention time (MRT) were calculated. Pathological sections were stained to study the safety of the microsphere tissues. A rabbit sciatic nerve model was used to determine the “standard time (t0)” and effective radius of the microspheres.

Results

The optimized lidocaine microspheres exhibited significantly reduced particle size and increased drug loading and encapsulation rates. Pharmacokinetic experiments showed that thet1/2,Tmax, and MRT of magnetically targeted lidocaine microspheres were significantly prolonged in the magnetic field, and the AUC0-48and AUC0-∞were significantly decreased. Its pharmacodynamic radius was 31.47 mm.

Conclusion

Magnetically targeted lidocaine microspheres provide sustained long-lasting release, neurotargeting, nerve blocking, and high tissue safety. This preparation has a significantly low blood concentration and a slow release in vivo, which can reduce local anesthetic entry into the blood. This may be a novel and effective method for improving postoperative comfort and treating chronic pain. This provides a countermeasure for exploring the size of the magnetic field for the application of magnetic drug-carrying materials.
Impact of medium anisotropy on quarkonium dissociation and regeneration
Authors: Singh Captain R. , Jamal Mohammad Yousuf , Sahoo Raghunath
Published: September 2024

Quarkonium production in ultra-relativistic collisions plays a crucial role in probing the existence of hot QCD matter. This study explores quarkonia states dissociation and regeneration in the hot QCD medium while considering momentum anisotropy. The net quarkonia decay width ($$\Gamma _{D}$$

Γ
D

) arises from two essential processes: collisional damping and gluonic dissociation. The quarkonia regeneration includes the transition from octet to singlet states within the anisotropic medium. Our study utilizes a medium-modified potential that incorporates anisotropy via particle distribution functions. This modified potential gives rise to collisional damping for quarkonia due to the surrounding medium, as well as the transition of quarkonia from singlet to octet states due to interactions with gluons. Furthermore, we employ the detailed balance approach to investigate the regeneration of quarkonia within this medium. Our comprehensive analysis spans various temperature settings, transverse momentum values, and anisotropic strengths. Notably, we find that, in addition to medium temperatures and heavy quark transverse momentum, anisotropy significantly influences the dissociation and regeneration of various quarkonia states.
Fast energy decay for wave equation with a monotone potential and an effective damping
Authors: Li Xiaoyan , Ikehata Ryo
Published: September 2024

We consider the total energy decay of the Cauchy problem for wave equations with a potential and an effective damping. We treat it in the whole one-dimensional Euclidean space [Formula: see text]. Fast energy decay like [Formula: see text] is established with the help of potential. The proofs of main results rely on a multiplier method and modified techniques adopted in [R. Ikehata and Y. Inoue, Total energy decay for semilinear wave equations with a critical potential type of damping, Nonlinear Anal. 69(4) (2008) 1396–1401].
Generation and Editing of 2D Shapes Using a Branched Representation
Authors: Alvarez Luis , Trujillo Agustín , Monzón Nelson , Morel Jean-Michel
Published: September 2024

In this article, we propose a new planar shape representation, the medial branch graph representation (MBGR) which allows to easily generate, vary and edit all-new sorts of parametric shapes. Each MBGR shape is described by a collection of connected control circles organized as a graph. Each pair of connected circles generates a branch of the shape. The boundaries of the branches are designed using cubic Bézier curves which enable shape representation in a compact SVG format. Each circle is associated with a regularity parameter locally controlling the smoothness of the branch connections. In this way, we can manage shapes having both sharp corners and smooth boundaries. To illustrate the potential of the MBGR representation, we have created an online facility (
https://mbgrg.github.io/mbgrg/
) where the user can create/edit MBGR shapes automatically or interactively.
Use of Pretreatment Perfusion MRI–based Intratumoral Heterogeneity to Predict Pathologic Response of Triple-Negative Breast Cancer to Neoadjuvant Chemoimmunotherapy
Authors: Ramtohul Toulsie , Lepagney Victoire , Bonneau Claire , Jin Maxime , Menet Emmanuelle , Sauge Juliette , Laas Enora , Romano Emanuela , Bello-Roufai Diana , Mechta-Grigoriou Fatima , Vincent Salomon Anne , Bidard François-Clément , Langer Adriana , Malhaire Caroline , Cabel Luc , Brisse Hervé J. , Tardivon Anne
Published: September 2024

A radiomics score derived from pretreatment perfusion MRI effectively predicted pathologic complete response in participants with early-stage triple-negative breast cancer following neoadjuvant chemoimmunotherapy.
An Electro-Chemo-Mechanic Model Resolving Delamination between Components in Complex Microstructures of Solid-State Batteries
Authors: Schmidt Christoph P. , Sinzig Stephan , Wall Wolfgang A.
Published: September 2024

A novel approach is presented to model delamination and recontacting at internal interfaces of three-dimensional resolved microstructures of solid-state batteries. To resolve the effect of delaminations, we incorporate the consistent enforcement of contact constraints at those interfaces using Nitsche’s method. The model incorporates charge, mass, and momentum conservation to consider electrochemistry, solid mechanics, and their interaction. After introducing and verifying the model, we examine various scenarios to quantify the effect of delaminations at the electrode-solid electrolyte interface on cell performance. The simulations show that increased mechanical stack pressure during cycling mitigates delamination tendencies at the electrode-solid electrolyte interface. Consistent with existing literature, the simulations demonstrate that delaminations increase the internal resistance and reduce the amount of transferred charge. In contrast to experimental analyses, the presented model allows quantitative and in-depth investigations of delamination effects. Furthermore, our analysis of two cell concepts—one assembled in the discharged state and another assembled in the charged state—indicates that half-cells assembled in an initial state from which the active material shrinks in volume upon first charge or discharge show a higher delamination risk at the electrode-solid electrolyte interface. The study highlights the critical relationship between solid mechanics and electrochemistry in consideration of delamination phenomena in solid-state batteries, offering valuable insights for optimizing battery design and performance.
Identifying Problematic Phase Transformations in Pb Foil Anodes for Sodium-Ion Batteries
Authors: Zhang Jia , Zheng Tianye , Guo Xiaoyang , Nguyen Hung Quoc , Cheng Ka-wai Eric , Lam Kwok-Ho , Rettenwander Daniel , Jin Wei , Boles Steven T.
Published: September 2024

Group IVA elements have aroused attention in sodium-ion batteries (SIBs) due to their Na-storage capability. Among them, Pb is less explored perhaps due to its perceived risks, but its long-standing success in Pb-acid batteries should not be neglected. Together with the well-established recycling procedures, the merits of Pb warrant further investigations as a practical SIB anode. In this work, four intermetallic phases are detected during electrochemical sodiation of Pb, which yields a capacity of ∼460 mAh·g−1 (∼1167 mAh·cm−3) upon the formation of Na15Pb4. When pursuing full capacities, the electrode stops functioning after only 3–4 cycles largely due to electrode physical damage. The reversibility of each phase transformation pair is then assessed to explore the origins of capacity fading. The NaPb/Na9Pb4 transformation shows the worst stability, consistent with the observed structural damage (e.g., cracks and voids). Through bypassing the problematic phase transformations using a partial cycling protocol, the stability of Pb foil anodes is improved, giving 20 cycles with 85% capacity retention. Considering other factors are unoptimized, it is suggested that the Pb-based anodes should not be fully eliminated from the future roadmap of SIBs, as the prospective merits can create value to ensure the management of such materials of concern.
Waste Bakelite Board Derived Activated Carbon for Supercapacitor Electrode
Authors: Saputro B. W. , Yang T. H. , Bolagam R. , Li S. Y. , Nguyen T. X. , Chiang T. H. , Ting J. M.
Published: September 2024

The low biodegradability of Bakelite waste raises concerns for the environment as it is typically dumped in landfills. Herein we present regenerated activated carbon (AC) prepared from waste Bakelite board. Preparation of the ACs involves carbonization and KOH activation. Afterwards, the as-made AC were doped with N urea and subsequently pyrolyzed at high temperature. The resulting AC, with and without N-doping have been evaluated in supercapacitor. We demonstrate an N-doped AC that exhibits a specific capacitance (Csp) as high as 203.0 F g−1 at 0.5 A g−1 and retains 93.1% of the Csp after 5000 galvanostatic charge discharge (GCD) cycles at 3 A g−1. We also show that a symmetric supercapacitor exhibits a maximum energy density of 10.3 Wh kg−1 at 250 W kg−1. In general, our work shows a cost-effective approach towards high-performance waste-regenerated ACs.
Somatostatin peptides prevent increased human colonic epithelial permeability induced by hypoxia
Authors: Rajput Ibrahim , Rajendran Vazhaikkurichi M. , Nickerson Andrew J. , Lodge J. Peter A. , Sandle Geoffrey I.
Published: September 2024

Somatostatin (SOM, 2 µM) and octreotide (OCT, 0.2 µM, a long-acting synthetic analog of SOM) were equally effective in preventing chemical hypoxia-induced increases in paracellular shunt permeability/conductance in isolated human colon. In rat distal colon, chemical hypoxia significantly increased total epithelial conductance and transepithelial movement of FITC-dextran 4000, changes completely prevented by 0.2 µM OCT. OCT may prevent or limit gut ischemia during abdominal surgery, thereby decreasing the risk of bacterial/bacterial toxin translocation and sepsis.
Astragaloside IV Treats Parkinson’s Disease by Regulating the Proliferation and Differentiation of NSCs through the SHH–Nurr1 Pathway
Authors: Wu Zicong , Zhang Jianing , Gao Han , Li Wentao
Published: September 2024

Recently, there has been a surge of interest in enhancing the differentiation of neural stem cells (NSCs) and supplementing dopamine neurons as a potential treatment for Parkinson’s disease, the second most prevalent neurodegenerative disorder. Two factors, sonic hedgehog (SHH) and nuclear receptor–related 1 protein (Nurr1), have been identified as influential in NSCs differentiation. Additionally, Astragaloside IV (AS‐IV), an active compound derived from Astragalus, has also been discovered to impact NSCs differentiation. To assess the effects of AS‐IV on cell activity, CCK‐8 and flow cytometry techniques were employed. Meanwhile, western blotting, immunofluorescence, and real‐time PCR were utilized to detect protein expression both in vivo and in vitro. Furthermore, siRNA assay was used to verify the association between SHH and Nurr1 and to investigate whether AS‐IV exerts its effects through this pathway. The experimental findings revealed that AS‐IV enhances cell activity and promotes the expression of differentiation proteins related to NSCs. Furthermore, the relationship between the SHH–Nurr1 pathway was confirmed, demonstrating that AS‐IV induces NSCs differentiation via this pathway. Consequently, SHH, acting as the upstream signaling pathway of Nurr1, influences its expression, while AS‐IV regulates the proliferation and differentiation of NSCs by modulating the SHH–Nurr1 pathway.
New Instruments for the Management of Cochlear Implantation in an Individual with a Fracture of the Temporal Bone and Cochlear Ossification
Authors: Frisina Antonio , Seno Francesco , Conni Gionata
Published: September 2024

Cochlear implant surgery can be highly complex in cases where ossification of the internal ear has taken place. In this case report, we report the use of new technological instruments to optimise the surgical process of implantation. These were the combined use of a surgical approach extended by a subtotal petrosectomy, a pre‐operative radiological study with the OTOPLAN software for choosing the most suitable electrode array, and a residual functionality test of the auditory nerve using the ANTS test electrode array prior to inserting the cochlear implant electrode array. These were used to successfully treat a case of total deafness caused by a fracture in the temporal bone complicated with ossification of the basal turn of the cochlea. These instruments ensured that the operation was performed with excellent results, reducing the risk of failure to a minimum in this complex case.
Supplementary Table 1 from Use of Nonsteroidal Anti-Inflammatory Drugs and Pancreatic Cancer Risk in the Women’s Health Initiative
Authors: Brasky Theodore M. , Jager Leah R. , Newton Alison M. , Li Xilin , Loomans-Kropp Holli A. , Hays John L. , Margolis Karen L. , Luo Juhua
Published: September 2024

Supplemental Table 1, shows associations of NSAIDs/aspirin with pancreatic cancer risk by categories of smoking, alcohol, and body mass index.
Supplementary Table S3 from Long-Term Risks of Cardiovascular Death among Older Patients with Major Hematological Malignancies: A Population-Based Cohort Study from SEER Database
Authors: Zhang Hanqing , He Minghao , Zhang Peng , Gao Yang , Ouyang Ling , He Xianjun , Han Na , Zhang Jinfeng , Guan Mengshan , Feng Yueqi , Li Yonghua
Published: September 2024

Supplementary Table S3. The classifications of other non-malignancies cause of death.
Supplementary Methods S1 from Exercise and QUality Diet after Leukemia: A Randomized Weight Loss Trial among Adult Survivors of Childhood Leukemia in the Childhood Cancer Survivor Study
Authors: Friedman Danielle N. , Chou Joanne F. , Clark Jeanne M. , Moskowitz Chaya S. , Ford Jennifer S. , Armstrong Gregory T. , Mubdi Nidha Z. , McDonald Aaron , Nathan Paul C. , Sklar Charles A. , Ramanathan Lakshmi V. , Robison Leslie L. , Oeffinger Kevin C. , Tonorezos Emily S.
Published: September 2024

Supplementary Methods S1 is the EQUAL study protocol with details of intervention and control group materials.
Data from Long-Term Risks of Cardiovascular Death among Older Patients with Major Hematological Malignancies: A Population-Based Cohort Study from SEER Database
Authors: Zhang Hanqing , He Minghao , Zhang Peng , Gao Yang , Ouyang Ling , He Xianjun , Han Na , Zhang Jinfeng , Guan Mengshan , Feng Yueqi , Li Yonghua
Published: September 2024

AbstractBackground:
The objective of this study was to identify the risk of cardiovascular disease (CVD)-related death in older patients with major hematological malignancies (HM).
Methods:
This study included 103,102 older patients diagnosed with seven major types of HM between 1975 and 2018 (median follow-up: 2.7 years) from the Surveillance, Epidemiology, and End Result database. The proportion of deaths, Fine-Gray subdistribution hazards regression model, standardized mortality ratios (SMR), and absolute excess risk (AER) were used to evaluate the risk of CVD-related death.
Results:
For older patients with HM, CVD-related death ranked as the second leading cause of death, surpassed only by primary malignancy. Compared to the general older population, older patients with HM had higher SMR and AER of CVD-related deaths (SMR: 1.16–1.81; AER: 41.24–308.99), heart disease–related deaths (SMR: 1.19–1.90; AER: 39.23–274.69), and cerebrovascular disease–related deaths (SMR: 0.99–1.66; AER: −0.35 to 24.15). The proportion of deaths and cumulative mortality increased with the passage of survival time, especially in patients with Hodgkin lymphoma with stage I/II and those aged ≥85 years with chronic lymphocytic leukemia, surpassing primary malignancy. The risk of CVD-related death varied among different HM types.
Conclusions:
For older patients with HM, long-term cardiovascular risk management needs to be focused on while addressing the primary malignancy.
Impact:
Our results emphasize the need to manage long-term cardiovascular risk in older patients with hematological malignancies, especially in those identified as high-risk cases.
Data from Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non–Small Cell Lung Cancer
Authors: Trendowski Matthew R. , Watza Donovan , Lusk Christine M. , Lonardo Fulvio , Ratliff Valerie , Wenzlaff Angela S. , Mamdani Hirva , Neslund-Dudas Christine , Boerner Julie L. , Schwartz Ann G. , Gibson Heather M.
Published: September 2024

AbstractBackground:
African Americans have higher incidence and mortality from lung cancer than non-Hispanic Whites, but investigations into differences in immune response have been minimal. Therefore, we compared components of the tumor microenvironment among African Americans and non-Hispanic Whites diagnosed with non–small cell lung cancer based on PDL1 or tertiary lymphoid structure (TLS) status to identify differences of translational relevance.
Methods:
Using a cohort of 280 patients with non–small cell lung cancer from the Inflammation, Health, Ancestry, and Lung Epidemiology study (non-Hispanic White: n = 155; African American: n = 125), we evaluated PDL1 tumor proportion score (<1% vs. ≥1%) and TLS status (presence/absence), comparing differences within the tumor microenvironment based on immune cell distribution and differential expression of genes.
Results:
Tumors from African Americans had a higher proportion of plasma cell signatures within the tumor microenvironment than non-Hispanic Whites. In addition, gene expression patterns in African American PDL1-positive samples suggest that these tumors contained greater numbers of γδ T cells and resting dendritic cells, along with fewer CD8+ T cells after adjusting for age, sex, pack-years, stage, and histology. Investigation of differential expression of B cell/plasma cell–related genes between the two patient populations revealed that two immunoglobulin genes (IGKV2-29 and IGLL5) were associated with decreased mortality risk in African Americans.
Conclusions:
In the first known race-stratified analysis of tumor microenvironment components in lung cancer based on PDL1 expression or TLS status, differences within the immune cell composition and transcriptomic signature were identified that may have therapeutic implications.
Impact:
Future investigation of racial variation within the tumor microenvironment may help direct the use of immunotherapy.
Supplementary Table S1 from Streamlined Intraoperative Brain Tumor Classification and Molecular Subtyping in Stereotactic Biopsies Using Stimulated Raman Histology and Deep Learning
Authors: Reinecke David , Ruess Daniel , Meissner Anna-Katharina , Fürtjes Gina , von Spreckelsen Niklas , Ion-Margineanu Adrian , Khalid Florian , Blau Tobias , Stehle Thomas , Al-Shugri Abdulkader , Büttner Reinhard , Goldbrunner Roland , Ruge Maximilian I. , Neuschmelting Volker
Published: September 2024

Supplementary Table S1. Description of the SRH-based diagnostic accuracy of the first model in case of neuropathological diagnosed non-tumorous tissue from open resection procedures since the stereotactic-guided biopsy dataset contained only a few cases due to IRB protocol restrictions and the common non-invasive diagnostic differentiation by means of 18F-FET-PET CT/MRI to distinguish between tumorous and non-tumorous tissue, e.g., in recurrent tumor cases. Non-tumorous tissue samples of the brain summarized here were obtained non- or purposely from surrounding white or gray matter adjacent to the tumor during open tumor en bloc resections. After resection, these tissue parts were extracted from the whole tissue sample for further analysis. Further cases comprised space-occupying suspected tumorous lesions or post-radiotherapy lesions (e.g., pseudoprogression or radiogenic necrosis) due to immense edematous effect. The final FFPE-based diagnosis revealed non-tumorous tissue.
Supplementary Figure S3 from A Phase II Study of Potentiation of Pembrolizumab with Binimetinib and Bevacizumab in Refractory Microsatellite-Stable Colorectal Cancer
Authors: Lentz Robert W. , Friedrich Tyler J. , Blatchford Patrick J. , Jordan Kimberly R. , Pitts Todd M. , Robinson Hannah R. , Davis S. Lindsey , Kim Sunnie S. , Leal Alexis D. , Lee Mathew R. , Waring Meredith R.N. , Martin Anne C. , Dominguez Adrian T.A. , Bagby Stacey M. , Hartman Sarah J. , Eckhardt S. Gail , Messersmith Wells A. , Lieu Christopher H.
Published: September 2024

Supplementary Figure S3. Overall survival in the randomized cohorts.
Supplementary Table 4 from A Phase I/II Study of Valemetostat (DS-3201b), an EZH1/2 Inhibitor, in Combination with Irinotecan in Patients with Recurrent Small-Cell Lung Cancer
Authors: Choudhury Noura J. , Lai W. Victoria , Makhnin Alex , Heller Glenn , Eng Juliana , Li Bob , Preeshagul Isabel , Santini Fernando C. , Offin Michael , Ng Kenneth , Paik Paul , Larsen Christina , Ginsberg Michelle S. , Lau Yvonne , Zhang Xinyuan , Baine Marina K. , Rekhtman Natasha , Rudin Charles M.
Published: September 2024

Patient Representativeness
Supplementary Table S1 from Increased PVR Expression on Bone Marrow Macrophages May Promote Resistance to TIGIT Blockade in Multiple Myeloma
Authors: Lozano Ester , Mena Mari-Pau , Garrabou Glòria , Cardús Oriol , Díaz Tania , Moreno David F. , Mañé-Pujol Joan , Oliver-Caldés Aina , Battram Anthony , Tovar Natalia , Cibeira María-Teresa , Rodríguez-Lobato Luis-Gerardo , Bladé Joan , Fernández de Larrea Carlos , Rosiñol Laura
Published: September 2024

Clinical patient characteristics
Supplementary Figure S6 from Combination Targeted Therapy with Pembrolizumab and Lenvatinib in Progressive, Radioiodine-Refractory Differentiated Thyroid Cancers
Authors: French Jena D. , Haugen Bryan R. , Worden Francis P. , Bowles Daniel W. , Gianoukakis Andrew G. , Konda Bhavana , Dadu Ramona , Sherman Eric J. , McCue Shaylene , Foster Nathan R. , Nikiforov Yuri E. , Farias Ticiana D.J. , Norman Paul J. , Wirth Lori J.
Published: September 2024

Myeloid subset frequency in peripheral blood before and on treatment
Table 2 from Safety, Efficacy, and Biological Data of T-Cell–Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial
Authors: Pakola Santeri A. , Peltola Katriina J. , Clubb James H.A. , Jirovec Elise , Haybout Lyna , Kudling Tatiana V. , Alanko Tuomo , Korpisaari Riitta , Juteau Susanna , Jaakkola Marjut , Sormunen Jorma , Kemppainen Jukka , Hemmes Annabrita , Pellinen Teijo , van der Heijden Mirte , Quixabeira Dafne C.A. , Kistler Claudia , Sorsa Suvi , Havunen Riikka , Santos Joao M. , Cervera-Carrascon Victor , Hemminki Akseli
Published: September 2024

Adverse events related to TILT-123 therapy as judged and reported by the investigator, stratified by grade, cohort, and unique patients with reported adverse event.a
Figure 1 from Safety, Efficacy, and Biological Data of T-Cell–Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial
Authors: Pakola Santeri A. , Peltola Katriina J. , Clubb James H.A. , Jirovec Elise , Haybout Lyna , Kudling Tatiana V. , Alanko Tuomo , Korpisaari Riitta , Juteau Susanna , Jaakkola Marjut , Sormunen Jorma , Kemppainen Jukka , Hemmes Annabrita , Pellinen Teijo , van der Heijden Mirte , Quixabeira Dafne C.A. , Kistler Claudia , Sorsa Suvi , Havunen Riikka , Santos Joao M. , Cervera-Carrascon Victor , Hemminki Akseli
Published: September 2024

A, Trial outline. B, Lymphocyte changes after TILT-123, all cohorts pooled. C, Leukocyte changes after TILT-123, all cohorts pooled. D, Neutrophil changes after TILT-123, all cohorts pooled. E, Virus detection in blood by qPCR, before treatment, 1 hour post-treatment and 16 hours post-treatment, all dose cohorts available pooled (N = 10 patients). F, Virus detection in blood by qPCR 1 hour after intravenous dose, stratified by intravenous dose given. G, Virus detection in blood by qPCR 1 hour after intratumoral dose, stratified by intratumoral dose given. For all graphs, mean ± SEM shown. For B–D, P value from two-sided t test shown for graphs. LLOQ, lower limit of quantification; ns, non-significant (P > 0.05); *, P < 0.05; ****, P < 0.001.
Supplementary Information 1 from Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition
Authors: Schmiester Leonard , Brasó-Maristany Fara , González-Farré Blanca , Pascual Tomás , Gavilá Joaquín , Tekpli Xavier , Geisler Jürgen , Kristensen Vessela N. , Frigessi Arnoldo , Prat Aleix , Köhn-Luque Alvaro
Published: September 2024

Supplementary information containing detailed description of the modeling approach.
Supplementary Data 1 from A 5-Year Follow-up Clinical Study of the B-cell Maturation Antigen Chimeric Antigen Receptor T-cell Therapy HDS269B in Patients with Relapsed or Refractory Multiple Myeloma
Authors: Chen Dongjian , Zhu Yu , Chen Zhi , Jiang Songfu , He Haiyan , Qiang Wanting , Xiang Fang , Sun Xuedong , Du Juan
Published: September 2024

Supplementary Data
Supplementary Figure S4 from Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma
Authors: Pourmaleki Maryam , Jones Caitlin J. , Mellinghoff Sabrina D. , Greenstein Brian D. , Kumar Priyadarshini , Foronda Miguel , Navarrete Daniel A. , Campos Carl , Roshal Mikhail , Schultz Nikolaus , Shah Sohrab P. , Schietinger Andrea , Socci Nicholas D. , Hollmann Travis J. , Dogan Ahmet , Mellinghoff Ingo K.
Published: September 2024

Supplementary Figure S4. cHL tumors exhibit heterogeneity in immune cell composition and states.
Supplemental Figure 2 from Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets
Authors: Chen Monica F. , Yang Soo-Ryum , Tao Jessica J. , Desilets Antoine , Diamond Eli L. , Wilhelm Clare , Rosen Ezra , Gong Yixiao , Mullaney Kerry , Torrisi Jean , Young Robert J. , Somwar Romel , Yu Helena A. , Kris Mark G. , Riely Gregory J. , Arcila Maria E. , Ladanyi Marc , Donoghue Mark T.A. , Rosen Neal , Yaeger Rona , Drilon Alexander , Murciano-Goroff Yonina R. , Offin Michael
Published: September 2024

Supplemental Figure 2. Structures of novel BRAF fusions that had confirmatory RNA-sequencing and transcript IDs.
Supplementary Figure S11 from Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma
Authors: Pourmaleki Maryam , Jones Caitlin J. , Mellinghoff Sabrina D. , Greenstein Brian D. , Kumar Priyadarshini , Foronda Miguel , Navarrete Daniel A. , Campos Carl , Roshal Mikhail , Schultz Nikolaus , Shah Sohrab P. , Schietinger Andrea , Socci Nicholas D. , Hollmann Travis J. , Dogan Ahmet , Mellinghoff Ingo K.
Published: September 2024

Supplementary Figure S11. Intertumoral heterogeneity in regulatory T cell abundance.
Supplementary Table S4 from Targeting AKR1B10 by Drug Repurposing with Epalrestat Overcomes Chemoresistance in Non–Small Cell Lung Cancer Patient-Derived Tumor Organoids
Authors: Suvilesh Kanve N. , Manjunath Yariswamy , Nussbaum Yulia I. , Gadelkarim Mohamed , Raju Murugesan , Srivastava Akhil , Li Guangfu , Warren Wesley C. , Shyu Chi-Ren , Gao Feng , Ciorba Matthew A. , Mitchem Jonathan B. , Rachagani Satyanarayana , Kaifi Jussuf T.
Published: September 2024

Supplementary Table S4. IC50 values of cytotoxic agents against LUAC (n = 6) and LUSC (n = 6) cell lines.
Supplementary Table S2 from Targeting AKR1B10 by Drug Repurposing with Epalrestat Overcomes Chemoresistance in Non–Small Cell Lung Cancer Patient-Derived Tumor Organoids
Authors: Suvilesh Kanve N. , Manjunath Yariswamy , Nussbaum Yulia I. , Gadelkarim Mohamed , Raju Murugesan , Srivastava Akhil , Li Guangfu , Warren Wesley C. , Shyu Chi-Ren , Gao Feng , Ciorba Matthew A. , Mitchem Jonathan B. , Rachagani Satyanarayana , Kaifi Jussuf T.
Published: September 2024

Supplementary Table S2. Customized list of Epithelial cell and subtype specific markers used in MCP-counter analysis.
Supplementary File S3 from Targeting AKR1B10 by Drug Repurposing with Epalrestat Overcomes Chemoresistance in Non–Small Cell Lung Cancer Patient-Derived Tumor Organoids
Authors: Suvilesh Kanve N. , Manjunath Yariswamy , Nussbaum Yulia I. , Gadelkarim Mohamed , Raju Murugesan , Srivastava Akhil , Li Guangfu , Warren Wesley C. , Shyu Chi-Ren , Gao Feng , Ciorba Matthew A. , Mitchem Jonathan B. , Rachagani Satyanarayana , Kaifi Jussuf T.
Published: September 2024

Supplementary File S3. Differentially expressed genes between Resistant and Sensitive PDTOs.
Data from Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets
Authors: Chen Monica F. , Yang Soo-Ryum , Tao Jessica J. , Desilets Antoine , Diamond Eli L. , Wilhelm Clare , Rosen Ezra , Gong Yixiao , Mullaney Kerry , Torrisi Jean , Young Robert J. , Somwar Romel , Yu Helena A. , Kris Mark G. , Riely Gregory J. , Arcila Maria E. , Ladanyi Marc , Donoghue Mark T.A. , Rosen Neal , Yaeger Rona , Drilon Alexander , Murciano-Goroff Yonina R. , Offin Michael
Published: September 2024

AbstractPurpose:
Even though BRAF fusions are increasingly detected in standard multigene next-generation sequencing panels, few reports have explored their structure and impact on clinical course.
Experimental Design:
We collected data from patients with BRAF fusion–positive cancers identified through a genotyping protocol of 97,024 samples. Fusions were characterized and reviewed for oncogenic potential (in-frame status, non-BRAF partner gene, and intact BRAF kinase domain).
Results:
We found 241 BRAF fusion–positive tumors from 212 patients with 82 unique 5′ fusion partners spanning 52 histologies. Thirty-nine fusion partners were not previously reported, and 61 were identified once. BRAF fusion incidence was enriched in pilocytic astrocytomas, gangliogliomas, low-grade neuroepithelial tumors, and acinar cell carcinoma of the pancreas. Twenty-four patients spanning multiple histologies were treated with MAPK-directed therapies, of which 20 were evaluable for RECIST. Best response was partial response (N = 2), stable disease (N = 11), and progressive disease (N = 7). The median time on therapy was 1 month with MEK plus BRAF inhibitors [(N = 11), range 0–18 months] and 8 months for MEK inhibitors [(N = 14), range 1–26 months]. Nine patients remained on treatment for longer than 6 months [pilocytic astrocytomas (N = 6), Erdheim–Chester disease (N = 1), extraventricular neurocytoma (N = 1), and melanoma (N = 1)]. Fifteen patients had acquired BRAF fusions.
Conclusions:
BRAF fusions are found across histologies and represent an emerging actionable target. BRAF fusions have a diverse set of fusion partners. Durable responses to MAPK therapies were seen, particularly in pilocytic astrocytomas. Acquired BRAF fusions were identified after targeted therapy, underscoring the importance of postprogression biopsies to optimize treatment at relapse in these patients.
Figure S13 from Nivolumab Reaches Brain Lesions in Patients with Recurrent Glioblastoma and Induces T-cell Activity and Upregulation of Checkpoint Pathways
Authors: Skadborg Signe K. , Maarup Simone , Draghi Arianna , Borch Annie , Hendriksen Sille , Mundt Filip , Pedersen Vilde , Mann Matthias , Christensen Ib J. , Skjøth-Ramussen Jane , Yde Christina W. , Kristensen Bjarne W. , Poulsen Hans S. , Hasselbalch Benedikte , Svane Inge M. , Lassen Ulrik , Hadrup Sine R.
Published: September 2024

Tumor-reactive TILs.
Supplementary Figure 2 from Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors
Authors: Chang Ju-Fang , Wellhausen Nils , Engel Nils W. , Landmann Jack H. , Hopkins Caitlin R. , Salas-McKee January , Bear Adham S. , Selli Mehmet E. , Agarwal Sangya , Jadlowsky Julie K. , Linette Gerald P. , Gill Saar , June Carl H. , Fraietta Joseph A. , Singh Nathan
Published: September 2024

A, Expansion of T cells in which stimulation cultures did or did not contain IL7/IL15. B, CD4 and CD8 composition of and C, memory composition of T cell products at the conclusion of manufacturing when stimulation cultures did or did not include IL7/IL15.
Table S4 from Knocking Out CD70 Rescues CD70-Specific NanoCAR T Cells from Antigen-Induced Exhaustion
Authors: De Munter Stijn , Buhl Juliane L. , De Cock Laurenz , Van Parys Alexander , Daneels Willem , Pascal Eva , Deseins Lucas , Ingels Joline , Goetgeluk Glenn , Jansen Hanne , Billiet Lore , Pille Melissa , Van Duyse Julie , Bonte Sarah , Vandamme Niels , Van Dorpe Jo , Offner Fritz , Leclercq Georges , Taghon Tom , Depla Erik , Tavernier Jan , Kerre Tessa , Drost Jarno , Vandekerckhove Bart
Published: September 2024

Differentially expressed genes in nanoCAR T-cells from cluster CD8KO vs CD4KO
Figure S8 from MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming
Authors: Zewdie Eden Y. , Edwards George M. , Hunter Debra M. , Earp Henry Shelton , Holtzhausen Alisha
Published: September 2024

Supplemental Figure 8
Supplementary Table 2 from Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis
Authors: Castro-Pando Susana , Howell Rian M. , Li Le , Mascaro Marilina , Faraoni Erika Y. , Le Roux Olivereen , Romanin David , Tahan Virginia , Riquelme Erick , Zhang Yu , Kolls Jay K. , Allison James P. , Lozano Guillermina , Moghaddam Seyed J. , McAllister Florencia
Published: September 2024

Supplementary Table 2
Supplementary Figure 2 from Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis
Authors: Castro-Pando Susana , Howell Rian M. , Li Le , Mascaro Marilina , Faraoni Erika Y. , Le Roux Olivereen , Romanin David , Tahan Virginia , Riquelme Erick , Zhang Yu , Kolls Jay K. , Allison James P. , Lozano Guillermina , Moghaddam Seyed J. , McAllister Florencia
Published: September 2024

Supplementary Figure 2. IL-17RA in the pancreatic immune compartment is not required for tumorigenesis.
Supplementary Figure 11 from Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis
Authors: Castro-Pando Susana , Howell Rian M. , Li Le , Mascaro Marilina , Faraoni Erika Y. , Le Roux Olivereen , Romanin David , Tahan Virginia , Riquelme Erick , Zhang Yu , Kolls Jay K. , Allison James P. , Lozano Guillermina , Moghaddam Seyed J. , McAllister Florencia
Published: September 2024

Supplementary Figure 11: B7-H4 is involved in PanINs progression
Table S1 from Knocking Out CD70 Rescues CD70-Specific NanoCAR T Cells from Antigen-Induced Exhaustion
Authors: De Munter Stijn , Buhl Juliane L. , De Cock Laurenz , Van Parys Alexander , Daneels Willem , Pascal Eva , Deseins Lucas , Ingels Joline , Goetgeluk Glenn , Jansen Hanne , Billiet Lore , Pille Melissa , Van Duyse Julie , Bonte Sarah , Vandamme Niels , Van Dorpe Jo , Offner Fritz , Leclercq Georges , Taghon Tom , Depla Erik , Tavernier Jan , Kerre Tessa , Drost Jarno , Vandekerckhove Bart
Published: September 2024

Differentially expressed genes per cluster
Movie 3 from Knocking Out CD70 Rescues CD70-Specific NanoCAR T Cells from Antigen-Induced Exhaustion
Authors: De Munter Stijn , Buhl Juliane L. , De Cock Laurenz , Van Parys Alexander , Daneels Willem , Pascal Eva , Deseins Lucas , Ingels Joline , Goetgeluk Glenn , Jansen Hanne , Billiet Lore , Pille Melissa , Van Duyse Julie , Bonte Sarah , Vandamme Niels , Van Dorpe Jo , Offner Fritz , Leclercq Georges , Taghon Tom , Depla Erik , Tavernier Jan , Kerre Tessa , Drost Jarno , Vandekerckhove Bart
Published: September 2024

CD70-specific nanoCAR T-cells incubated with CD70- JD041T organoid line
Supplementary Table 4 from A Multicenter Real-life Prospective Study of Axicabtagene Ciloleucel versus Tisagenlecleucel Toxicity and Outcomes in Large B-cell Lymphomas
Authors: Stella Federico , Chiappella Annalisa , Casadei Beatrice , Bramanti Stefania , Ljevar Silva , Chiusolo Patrizia , Di Rocco Alice , Tisi Maria C. , Carrabba Matteo G. , Cutini Ilaria , Martino Massimo , Dodero Anna , Bonifazi Francesca , Santoro Armando , Sorà Federica , Botto Barbara , Barbui Anna M. , Russo Domenico , Musso Maurizio , Grillo Giovanni , Krampera Mauro , Olivieri Jacopo , Ladetto Marco , Cavallo Federica , Massaia Massimo , Arcaini Luca , Pennisi Martina , Zinzani Pier L. , Miceli Rosalba , Corradini Paolo
Published: September 2024

Supplementary Table 4 – Detailed eligibility criteria in accordance with AIFA (Agenzia Italiana Farmaco)
Supplementary Table 3 from A Multicenter Real-life Prospective Study of Axicabtagene Ciloleucel versus Tisagenlecleucel Toxicity and Outcomes in Large B-cell Lymphomas
Authors: Stella Federico , Chiappella Annalisa , Casadei Beatrice , Bramanti Stefania , Ljevar Silva , Chiusolo Patrizia , Di Rocco Alice , Tisi Maria C. , Carrabba Matteo G. , Cutini Ilaria , Martino Massimo , Dodero Anna , Bonifazi Francesca , Santoro Armando , Sorà Federica , Botto Barbara , Barbui Anna M. , Russo Domenico , Musso Maurizio , Grillo Giovanni , Krampera Mauro , Olivieri Jacopo , Ladetto Marco , Cavallo Federica , Massaia Massimo , Arcaini Luca , Pennisi Martina , Zinzani Pier L. , Miceli Rosalba , Corradini Paolo
Published: September 2024

Supplementary Table 3 – Summary of real-world data
Supplemental Table 3 from Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition
Authors: Sarchi Martina , Clough Courtnee A. , Crosse Edie I. , Kim Jason , Baquero Galvis Laura D. , Aydinyan Nelli , Wellington Rachel , Yang Feini , Gallì Anna , Creamer J. Philip , Stewart Sintra , Bradley Robert K. , Malcovati Luca , Doulatov Sergei
Published: September 2024

Supplemental Table 3. Drug screening of WT (Ctrl), SF3B1 K700E (S-A), SF3B1/RUNX1 (S-R), and SF3B1/STAG2 (S-S) K562 cells with the AML OncoPanel1 of 165 FDA-approved compounds.
Figure 6 from Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-Cell Lymphoma
Authors: Meriranta Leo , Sorri Selma , Huse Kanutte , Liu Xiaonan , Spasevska Ivana , Zafar Sadia , Chowdhury Iftekhar , Dufva Olli , Sahlberg Eerika , Tandarić Luka , Karjalainen-Lindsberg Marja-Liisa , Hyytiäinen Marko , Varjosalo Markku , Myklebust June H. , Leppä Sirpa
Published: September 2024

Interrogation of CD79B at the protein level in the discovery set and KLHL6-mutated tumors. P values for comparisons between two groups in box plots are calculated with the Mann–Whitney U test. Individual channels shown for the white dashed areas are shown right to the microscopy images. A, IF microscopy image of a GC in a reactive lymph node showing the highest CD79B intensity in the mantle zone, whereas KLHL6 positivity is restricted to the GC. Scale bar, 100 µm. B and C, Box and dot plots with y-axis showing (B) quantified CD79B intensity and (C) CD79B gene expression (from RNA sequencing) according to KLHL6GC+ IHC (x-axis). D, Box and dot plots of quantified CD79B intensity according KLHL6GC+ IHC phenotype within different molecular subtypes determined by gene expression profiling. E, Representative IF microscopy images of KLHL6GC- tumors showing plasma membrane–like CD79B staining. Sections stained for CD79B, KLHL6, and DNA (DAPI) and images obtained with optical sectioning and 40× objective. Scale bar, 20 µm. F, Oncoprint of patients (columns) with KLHL6 and/or CD79B mutations (n = 23). G, Box and dot plot of CD79B intensity according to KLHL6 BTB domain encoding mutation status. Amino acid changes of all KLHL6 mutations for available cases are annotated, and the presence of CD79B mutations is indicated with a color. H, Box and dot plot showing CD79B intensity according to CD79B mutations with Y197 hot spot considered separately. Color of the dots indicates KLHL6GC IHC status and amino acid changes of CD79B mutations are annotated. I, Representative IF microscopy images of tumors with different KLHL6 mutations co-stained for CD79B, KLHL6, and DNA (DAPI). Images within dashed area indicate additional KLHL6-mutated DLBCL tumors not included in the discovery cohort. Scale bar, 20 µm applies to all images.
Figure 3 from Anti-HDGF Antibody Targets EGFR Tyrosine Kinase Inhibitor–Tolerant Cells in NSCLC Patient-Derived Xenografts
Authors: Zhou Cindy Q. , Li Ariel , Ri Kaoru , Sultan Ahmed S. , Ren Hening
Published: September 2024

Dynamics of EGFR signaling during the early stage of osimertinib treatment. Mice bearing TM00219 tumors were treated with osimertinib (10 mg/kg per os, every 24 hours) for up to 72 hours. Duplicate tumor samples were serially collected at indicated time intervals. Each tumor was split for formalin-fixing and paraffin-embedding and snap-freezing in liquid nitrogen. Duplicate formalin-fixed, paraffin-embedded sections were stained with (A) P-EGFR (Y1068), (B) P-Erk1/2 (T202/Y204), (C) P-Akt1 (S473), and (D) P-PRAS40 (T246). Stained slides were scanned using Olympus VS120 Pathology Slide Scanner. Representative images were extracted from OlyVIA at 4× view. Western blots of tumor protein extracts (10 μg/lane) from the corresponding serially collected samples probed with indicated antibodies (E).
A Bibliometric Analysis of the 100 Most-Cited Articles Concerning Atraumatic Restorative Treatment
Authors: Souza Isadora Durante de , Rocha Aurélio de Oliveira , Mulinari Julia , Santos Pablo Silveira , Cardoso Mariane , Santana Carla Miranda
Published: September 2024

Introduction: The present study aimed to identify the 100 most-cited articles concerning atraumatic restorative treatment (ART) through a bibliometric analysis. Methods: The search was conducted in the Web of Science database in December 2023. Scopus and Google Scholar were used to compare the number of citations. The following data were extracted from the articles: title, authors, number of citations, access type, institution, country, continent, year of publication, journal, keywords, study design, and theme. Collaborative networks were generated using the VOSviewer software. Google Trends was used to investigate the global popularity of “atraumatic restorative treatment” research. Results: The 100 selected articles, published between 1996 and 2019, were cited 5,092 times, ranging from 21 to 239 citations. CariesResearch (12%) and Community Dentistry and Oral Epidemiology (12%) published the highest number of articles. Clinical study (52%) was the most prevalent study design. The main theme addressed was restoration longevity (43%). Conventional high-viscosity glass ionomer was the most used restorative material (69%). The country with the highest number of articles was The Netherlands (33%) and Europe was the continent with most publications (38%). The Radboud University of Nijmegen had the highest number of articles (25%). Frencken was the most prominent author (38%). The most common keyword was “atraumatic restorative treatment” (n = 60). According to Google Trends, Tanzania was the country that searched the most about ART. Conclusion: The 100 most-cited articles on ART were mainly composed of clinical studies focusing on the longevity of restorations and originated in Europe.