bluuebunny/crossref_metadata_2025 huggingface dataset:
Genotypic and Phenotypic Study of PDCD4 gene Concerning micro RNA-21 and micro RNA-449b Polymorphism in Breast Cancer
Authors: Al-Janaby Mohammed Salih , Al-Ani Mohammed Q. , Lafta Fadhel M.
Published: February 2025

Breast cancer is a heterogeneous disease with a significant impact of genes involved in apoptosis. Hence, this study aims to assess the contribution of programmed cell death protein 4(PDCD4) miR-21, miR-449b and PDCD4 genes polymorphism in breast cancer pathogenicity. A total of 180 blood samples were collected from Iraqi women aged between 15-80 years, 120 samples were included from breast cancer patients (divided into two groups of 60 patients under treatment and 60 post treatments and recovery) then 60 healthy women as a control group. The extracted genomic DNA was amplified by PCR technique for the loci of interest and PCR products of the tested samples were genotyped using TaqMan real time fluorescent oligonucleotide for SNPs analysis. PDCD4 protein concentration in serum was estimated utilizing ELISA. The results showed significant association (P = 0.016) of miR-449b rs10061133:A>G polymorphism (AA, AG and GG) on the PDCD4 serum levels (3.62 ng/L, 4.75 ng/L and 2.58 ng/L respectively). PDCD4 serum showed to differ significantly (p = 0.001) among the investigated groups: treatment (5.39  ng/L), post-treatment (3.42ng/L), and control (3.19  ng/L). An evaluation of the effects of breast cancer risk factors on the studied parameter revealed that breastfeeding appears to significantly influence PDCD4 serum levels. Women who breastfed exhibited a mean PDCD4 concentration of 4.40 ng/L, compared to 3.25 ng/L for those who did not breastfeed (P=0.026). Additionally, the AUC value (0.7) suggests that PDCD4 protein could be a good predictive marker for treatment response. Overall, the phenotypic expression of PDCD4 demonstrated to be significantly influenced by polymorphisim of PDCD4, miR-21 and miR-449b SNPs, with a considerable impact of breastfeeding in increasing PDCD4 levels that could be utilized to promote breast cancer prevention strategies.
Estimation of miRNA 208 Effects in Inducing Epithelial-Mesenchymal Transition by Targeting CDH2 in Breast Cancer Patients of Iraqi Population
Authors: Salih Arwa M. , Aziz Ismail H. , Mohsin Forat Yahya
Published: February 2025

Breast cancer is the most frequently diagnosed disease in women and remains a leading cause of cancer-related deaths worldwide. The small non-coding RNA molecule, MicroRNA-208 (miR-208), plays a crucial role in the development and advancement of numerous malignancies, including breast cancer. This study aimed to investigate miR-208 potential as an oncogene in breast cancer by examining its impact on cell motility and epithelial-mesenchymal transition (EMT). Tissue samples from 25 Iraqi women with malignant breast cancer and 25 with benign breast cancer were analysed. Total RNA was extracted from the samples and real-time reverse transcription-polymerase chain reaction (RT-PCR) was performed using SYBR Green technology to measure miR-208 expression levels. Tissue samples from both benign and malignant tumours were analysed to determine U6 gene expression. The analysis showed that the typical Ct values for benign and malignant samples were 29.83 and 29.67 respectively. No significant difference in U6 expression levels was detected between benign and malignant tumours. However, upon comparing the initial malignant and the benign tumours samples, miRNA-208 ΔΔCT values were found to be substantially lower (-7.105 and -0.781 respectively) with a p-value of less than 0.05. The study found that malignant tumours had a significantly higher miRNA-208 folding value (2.896±) compared to benign tumours which had substantially lower miRNA-208 folding values (1.591 ±0.37). The study also found that the differences were statistically significant (p-value = 1.292*). In conclusion, the study found evidence linking miR-208 to the CDH2 gene, indicating its role in the development and susceptibility to breast cancer in certain Iraqi women.
Influência das características familiares na ansiedade dos pais de crianças com Transtorno do Espectro Autista
Authors: Sena Flávia Cristine Abreu , Flório Flavia Martão , Souza Luciane Zanin de
Published: February 2025

Objetivo: Avaliar a influência das características familiares na ansiedade dos pais de crianças com transtorno do espectro autista (TEA). Métodos: Estudo transversal descritivo-analítico com 161 pais de crianças com TEA de São Luís, Maranhão. A coleta ocorreu entre os meses de setembro de 2022 a fevereiro de 2023 por meio de questionários digitais, contendo 3 blocos: caracterização socioeconômica e necessidades dos pais; Escala de Depressão, Stress e Ansiedade (EADS-21); e a Escala de Avaliação da Adaptabilidade e Coesão Familiar II. Foram realizadas análises descritivas e analíticas por meio do Odds Ratio ( 0,05). Resultados: A maioria da amostra era do sexo feminino (92,6%), com idade média de 39,3 (±6,9) anos e 41% estavam desempregados. Famílias com menor coesão têm o dobro de probabilidade de apresentar um grau mais elevado de ansiedade (OR=2,14; IC95%=1,10-4,16), bem como as famílias com menor adaptabilidade também possuem duas vezes mais chance de maior grau de ansiedade (OR=2,10; IC95%=1,02-4,33). Conclusão: Famílias com menor coesão e menor adaptabilidade têm um risco duas vezes maior de apresentar níveis mais elevados de ansiedade.
Disfunções do Complexo de Golgi na progressão do câncer de Próstata: uma Revisão Integrativa
Authors: Gonçalves Giliard Klévio de Oliveira , Lima Adriano Justino de , Gbassi Armel , Pedrosa Gustavo Casimiro , Silva Jailton dos Santos , Martins Matheus Domingues , Lira Rafaelle Cavalcante de
Published: February 2025

Objetivo: Analisar a relação entre as disfunções do Complexo de Golgi e o câncer de próstata. Métodos: Revisão integrativa da literatura realizada nas bases indexadas PubMed, Scopus e Embase ocorrida em novembro de 2023. Foram utilizados para pesquisa os descritores DeCS/MeSH “cancer of prostate”, “golgi apparatus” e “golgi translational post” e seus termos alternativos formando combinações de palavras-chaves com operadores booleanos. Resultados: A amostra final foi composta por 12 artigos, os quais descrevem diversos mecanismos ligados às cascatas de eventos pós traducionais do Complexo de Golgi que induzem à fragmentação dessa organela em células de próstata cancerígenas. Conclusão: A fragmentação das cisternas de Golgi foi uma evidência característica dos precursores do câncer prostático assim como a relação direta entre o abuso de álcool e a cisão dessa organela. Contudo, faz-se necessário aprimorar esses entendimentos, pois os resultados in vitro possuem limitações ao extrapolar para o contexto do organismo inteiro. Nesse sentido, a aplicabilidade clínica das descobertas depende do desenvolvimento de inibidores capazes neutralizar uma cascata de eventos complexa e multifatorial.
Microbiological and in silico evaluation of triazole and bi-triazole derivatives
Authors: Martinez Leandro do Nascimento , Silva Minelly Azevedo da , Gouveia Aurileya de Jesus , Fialho Saara Neri , Cabral Gustavo de Amorim Barbosa , Santana Quelli Larissa Oliveira , Bastos Ivanildes dos Santos , Orlandi Patricia Puccinelli , Ferreira Sabrina Baptista , Teles Carolina Bioni Garcia
Published: February 2025

Objective: To determine the antibacterial activity of triazole and bi-triazole compounds against the pathogens Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus (MRSA). Methods: This targeted research was combined with in silico predictions aimed at the rational and safe screening of these compounds. For this purpose, the virtual programs Osiris, Molinspiration, and ADMETlab were used. The inhibitory potential of the compounds was evaluated by the agar dilution method and by determining the Minimum Inhibitory Concentration (MIC). Results: The results showed that none of the nine compounds exhibited promising levels of bacterial inhibition at the maximum concentration of 500 μg/mL in both tests. These results suggest the need to add other radicals to the pharmacophoric group of triazoles and bi-triazoles to achieve antibacterial action against these species. Although the triazoles and bi-triazoles tested were not effective in bacterial inhibition, the in silico predictions for physicochemical properties revealed that all compounds met Lipinski's and Veber's rules in the development of a potential oral drug. Conclusion: These in silico results indicate that both chemical classes have potential for developing a possible prototype, provided that their relevant bioactivity against other diseases can be confirmed.
Análise dos principais riscos no uso irracional dos Inibidores da Bomba de Prótons
Authors: Grisólia Daniella Paternostro de Araújo , Souza Douglas Simão de , Brito Michelly Thayne Fernandes de , Branco Mateus de Oliveira Castelo , Diniz Marcelly Christine de Souza , Quaresma Cyanne Anastácia Seabra , Silva Jessica Maisa de Lima Braga da , Souza Izabella Beatriz Sousa de , Rodrigues Yasmim Pinheiro , Grisólia Alan Barroso Araújo
Published: February 2025

Objetivo: Analisar os principais riscos no uso irracional dos IBP’s. Métodos: Trata-se de uma revisão integrativa realizada por meio das bases de dados em saúde BVS e SciELO, com a busca de artigos científicos no período de 2011 a 2022, em português, inglês e espanhol, utilizando os Descritores em Ciências da Saúde (DeCS): Inibidores da bomba de prótons; Riscos do Uso Irracional; Efeitos Adversos; Interações Medicamentosas e Tratamento Farmacológico. Resultados: A busca resultou em 25 artigos, em seguida foi realizada leitura completa dos artigos com a aplicação dos critérios de inclusão e exclusão, foram incluídos 11 artigos que respondiam aos critérios de seleção. Conclusão:  Além dos riscos farmacológicos devido ao uso prolongado dos IBP’s, estes possuem interações com outros fármacos e alimentos, portanto deve ser usado com precaução pelos indivíduos para evitar interações indesejáveis durante o tratamento. O uso crônico e indiscriminado pode trazer muitas complicações à saúde, devendo haver cautela durante a prescrição médica e orientações aos usuários das consequências atribuídas ao uso prolongado de IBP’s a fim reduzir os efeitos adversos provocados e garantir a aplicação correta destes fármacos.
Fitoterápicos como alternativa à irrigação e medicação intracanal convencional: uma revisão de literatura
Authors: Sales Francisco Anderson de Sousa , Passos Vanara Florencio , Marques Vitória Moraes , Pinto Sérgio Araújo Holanda , Brito Jaqueline Ximenes , Ferreira Regina Glaucia Lucena de Aguiar
Published: February 2025

Objetivo: Este estudo teve como objetivo realizar uma revisão integrativa da literatura sobre o tema: "Endodontia e Fitoterápicos", identificando quais fitoterápicos mostram resultados promissores para irrigação e medicação intracanal. Métodos: A revisão incluiu artigos das bases de dados PubMed, Scielo e da plataforma Biblioteca Virtual em Saúde (BVS), nos últimos dez anos e utilizando os descritores: “phytotherapy”, “phytotherapeutic drugs”, “plants, medicinal” e “endodontics” e seus respectivos termos em português, combinados pelo operador booleano “OR”. Foram incluídos estudos em português e inglês, tanto in vitro quanto clínicos, focados no uso de fitoterápicos na irrigação e medicação intracanal, enquanto revisões de literatura e estudos em animais foram excluídos. Resultados: Os fitoterápicos mais destacados foram: própolis, gengibre, extrato de alho, camomila, copaíba, romã, aroeira-da-praia, unha-de-gato e cravo-da-Índia. As principais atividades biológicas que favorecem o tratamento endodôntico identificadas foram: anti-inflamatória, antibacteriana, antisséptica, cicatrizante, analgésica e antifúngica. Conclusão: Conclui-se que os fitoterápicos são promissores para futuras investigações e podem ser candidatos eficazes para formulações de irrigação ou medicação intracanal em tratamentos endodônticos.
Impactos da Covid-19 na notificação de leishmaniose visceral infantil no município de Parauapebas-PA
Authors: Aljonas Mariane Redivo , Martins Luísa Caricio
Published: February 2025

Objetivo: Analisar os impactos da pandemia na notificação da leishmaniose visceral infantil na cidade de Parauapebas-PA. Métodos: Trata-se de um estudo de coorte retrospectivo, conduzido com 104 pacientes diagnosticados por leishmaniose visceral, compreendidos zero a doze anos. Foram investigados os números de notificações por idade nos períodos pré-pandêmico (2014-2019) e pandêmico (2020-2021), avaliado o tipo de entrada no hospital, terapêuticas utilizadas e o desfecho dos casos. Para análise estatística foi utilizado o teste G, através dos softwares BioEstat 5.0 e GraphPad Prism 6.0. Resultados: Foram registrados 81 casos no período pré-pandêmico e 23 no período pandêmico, sendo a idade de um ano predominante nos anos de 2014 a 2019 e menores de um ano entre 2020 a 2021. Em relação ao tipo de entrada e ano do diagnóstico há predominância de casos novos em todos os anos analisados. O antimonial pentavalente foi considerado a droga de escolha independente dos períodos. Conclusão: Apesar de não apresentar diferença significativa nas notificações de leishmaniose visceral infantil entre os períodos, evidenciamos o quanto é importante ações políticas para promover o bem-estar da sociedade, principalmente daqueles que estão mais expostos a indicadores inaceitáveis de vida.
Tumor sincrônico de cólon
Authors: Silva Eduardo Reinaldo , Leli Luiz Fernando
Published: February 2025

Objetivo: Expor um caso clínico de paciente o qual apresentou tumor sincrônico de cólon, assim como fazer uma breve revisão literária sobre o tema. Além de, descrever outras estratégias diagnósticas que poderiam ter sido executadas para otimização da condução do tratamento. Detalhamento de Caso: Trata-se de um relato de caso a partir de análise de prontuário de um paciente masculino com 70 anos de idade submetido a colectomia esquerda em 2024, devido tumor de cólon que foi diagnosticado por meio de colonoscopia incompleta. Por isto, apenas no intraoperatório que pode ser diagnosticado com tumor sincrônico, ou seja, existiam duas massas tumorais intestinais. Considerações finais: Frente ao caso relatado, fica evidente que o estudo incompleto do cólon prejudica o diagnóstico dessa patologia, portanto sempre deve-se realizar inventário de cavidade abdominal em cirurgias que explorem tal segmento corporal, assim como utilizar instrumentos diagnósticos modernos como a colonografia por tomografia computadorizada, caso esteja disponível.
Perfil epidemiológico de trabalhadores com transtornos mentais relacionados ao trabalho nas regiões brasileiras entre 2019 e 2023: estudo ecológico
Authors: Morais Juliana Cavalcanti de , Moura Johanna Pocker Lemos Hourneaux de , Giocondo Isabella Armacolo , Milhomem Emanuela Lira
Published: February 2025

Objetivo: Conhecer e analisar o perfil epidemiológico dos transtornos mentais relacionados ao trabalho no Brasil. Métodos: Trata-se de um estudo ecológico realizado através de dados coletados no sistema de informação de agravos de notificação (SINAN), relativos a transtornos mentais relacionados ao trabalho nas regiões brasileiras entre 2019 e 2023. Resultados: Registrou-se um total de 11648 casos, dos quais 68,27% foram referentes ao sexo feminino, 68,27% à faixa etária de 35 a 49 anos, 46,03% à cor/raça branca, 32,41% a indivíduos com nível superior completo, 57,03% à ausência de utilização de drogas psicoativas, 56,52% à incapacidade temporária (evolução do caso), 46,83% ao CID F40-F48, 41,41% aos casos sem emissão de CAT e por fim, o agente comunitário de saúde (515105) mostrou-se a ocupação mais afetada. Conclusão: Os transtornos mentais relacionados ao trabalho causam sofrimento emocional e podem afetar diretamente o desempenho profissional e a qualidade de vida do trabalhador. Diante disso, mais estudos sobre a temática são necessários para explicar a relação entre o problema e os fatores associados.
Common cutaneous manifestations in hematological malignancies
Authors: Das Suchibrata
Published: February 2025

Hematologic malignancies (HMs) are among the most prevalent and diverse types of cancer. Patients with HMs may experience a wide range of skin-related issues. These dermatological manifestations can be grouped into three main categories: Direct skin infiltration by malignant cells or their byproducts, cutaneous effects indirectly linked to the malignancy, and skin changes resulting from treatment. Such dermatological issues can significantly impact a patient’s quality of life. Managing these complex conditions requires a collaborative, multidisciplinary approach. Close coordination between dermatologists and hematologists is crucial for accurate diagnosis, personalized treatment planning, and ongoing monitoring.
Pelatihan Edukasi Ilmu Faraidh Dalam Upaya Menyelesaikan Masalah Warisan di Masyarakat Aek Salak Lingkungan IV Kelurahan Pasar Sibuhuan
Authors: Siregar Nurfitryani , Siregar Lina Mayasari
Published: February 2025

Islam begitu memperhatikan berbagai persoalan pada umatnya, termasuk perihal warisan yang mampu menimbulkan pertikaian. Untuk itu terdapat ilmu khusus yang membahas tentang waris, dikenal dengan faraidh. Dalam asal kata 'faraidh' adalah 'fardh' berarti ukuran. Maka 'faraidh' yakni bagian-bagian yang terukur secara syariat untuk pemiliknya. Untuk definisi ilmu faraidh sendiri, yaitu ilmu tentang pembagian harta warisan sesuai dengan kaidah fikih, Sehingga ilmu faraidh merupakan ilmu yang berkaitan dengan pembagian harta waris, pengetahuan tentang cara perhitungan yang dapat menyelesaikan pembagian warisan dan pengetahuan tentang bagian-bagian yang semestinya dari harta peninggalan itu untuk setiap mereka yang punya hak. Kegiatan pengabdian kepada masyarakat ini dilatarbelakangi karena perlunya meningkatkan kesadaran masyarakat tentang ilmu faraidh, karena diketahui selama ini kurangnya minat masyarakat untuk mempelajari dan memahami ilmu faraidh sehingga berakibat pada pelaksanaan warisan yang tidak sesuai dengan syari’at Islam, oleh sebab itu PKM ini begitu urgen dilakukan.
EDITORIAL
Authors: Clement I
Published: February 2025

None
Levetiracetam versus Phenobarbitone in Neonatal Seizures - An Open label Randomized Controlled Trial
Authors: D Kulkarni Nikhil , Rao P N Suman , Lakshmi Parvathi B , Bhat Swarnarekha
Published: February 2025

BackgroundnbspPhenobarbitone is the traditional first-line anticonvulsant for neonatal seizures while levetiracetam a newer anti-epileptic has uncertain efficacy in comparisonObjectivenbspTo evaluate the efficacy and safety of levetiracetam versus phenobarbitone in term and preterm infants with clinically apparent seizures in a tertiary care neonatal setting guiding safer more effective neonatal seizure managementMethodsnbspThis study aimed to compare the efficacy and safety of levetiracetam 30 mgkgdose and phenobarbitone 20 mgkgdose in controlling neonatal seizures. An open-label parallel randomized controlled trial RCT was conducted in a neonatal intensive care unit NICU in IndiaResultsnbspSeizure cessation rates were 70 in the levetiracetam group and 66.6 in the phenobarbitone group with no statistically significant difference P 0.83.ConclusionnbspLevetiracetam and phenobarbitone demonstrated comparable efficacy and safety in managing neonatal seizures. Levetiracetam could be considered a viable alternative to phenobarbitone as a first-line treatment. Further studies are needed to confirm these findings especially regarding levetiracetams side effect profile.
Assessment of Knowledge on Side Effects Among Cancer Patients Receiving Radiotherapy in Selected Hospitals of West Bengal
Authors: Chowdhury Sukanya , Paul Chayan
Published: February 2025

Background and Aim Approximately 20 million new cases of cancer and 9.7 million cancer deaths will occur in 2022. Lung cancer is the most frequently diagnosed type of cancer. Radiotherapy is an integral part of cancer management and is associated with several adverse effects. Awareness of the general population is still poor in both developing and developed countries. Therefore knowledge assessment of patients with cancer is necessary to understand the lack of knowledge regarding cancer.Objectives This descriptive study aimed to assess the knowledge of the side effects of cancer patients receiving radiotherapy in selected hospitals in West Bengal.Method A total of 171 samples were selected using a non-probability purposive sampling technique and a validated structured interview schedule was used to collect data from the study samples.Results The study results showed that the mean and SD of knowledge score were 11.3 and plusmn3.06 respectively 25.1 of cancer patients had a poor level of knowledge and the majority of the study sample had side effects such as nausea fatigue weight loss and psychological changes. There was a significant association between the knowledge of cancer patients and sex educational status place of residence family history of cancer and duration of radiotherapy Plt0.001. This study has implications for nursing practice education administration and research.Conclusion The majority of the patients had a poor level of knowledge. Further studies with larger participants and different populations are required to understand the knowledge and awareness.
Brain Drain in Nigerian Health Sector: An Unsung Epidemic
Authors: OF Olowolaju , OA Akpor , OA Adeoluwa
Published: February 2025

Brain drain in the Nigerian health sector is a critical issue that has drained Nigeria of skilled and competent healthcare professionals thereby placing a heavy burden on the Nigerian healthcare system. The paper aimed to describe some factors responsible for the increase in brain drain and thereby offer possible solutions to the problem. The theory of push and pull factors was used to describe the phenomenon. Push factors are unfavourable conditions that push people out of their domain country while pull factors are favourable conditions that attract citizens to migrate to developed countries. The consequences of brain drain in the health sector led to the shortage of skilled healthcare workers which places a heavy burden on those who remain leading to increased workload and burnout. The paper also highlighted various efforts the Nigerian government had put in place to mitigate the effects of brain drain in Nigeria such as implementation of the national health policy increased funding for the health sector and strengthening of healthcare institutions. Unfortunately the efforts are yet to yield positive impacts. However this paper has several possible recommendations aimed at reversing brain drain in the health sector which include improvement of working conditions and remuneration development of retention strategies to retain healthcare professionals and addressing socioeconomic factors that contribute to brain drain. The study concluded that brain drain in the Nigerian health sector is a significant challenge that requires urgent attention and a multifaceted approach. Only then can Nigeria hope to alleviate the unsung epidemic of brain drain in its health sector.
Mothers’ Knowledge Regarding Prevention of Home Accidents Among Toddlers: A Cross-Sectional Study
Authors: Pal Singh Choudhary Narendra , Doris Lily A , Chauhan Soni , Kant Tiwari Surya
Published: February 2025

Background and aim Home accidents are a leading cause of mortality and morbidity among young children. Effective prevention of home accidents relies on a combination of protection and education with mothers playing a significant role as primary caregivers. This study aimed to assess mothersrsquo knowledge regarding the prevention of home accidents among toddlers.Methods A descriptive cross-sectional study was conducted from July 2023 to September 2023 among mothers of toddlers aged 1-3 years in Jaipur using a convenient sampling technique. Data were collected using a structured multiple-choice questionnaire with 30 items across eight domains related to home accident prevention.ResultsA descriptive survey included 100 mothers predominantly aged 21-25 years Hindus and with primary education. Most mothers had moderate knowledge 61 about preventing home accidents whereas 14 had inadequate knowledge. The highest knowledge was in the domains of foreign body aspiration 80.25 and general information about home accidents 74.83 while the lowest was in drowning 48.66. Significant associations were found between mothers knowledge and demographic variables such as age education occupation family income type of family number of toddlers type of house and source of knowledge.Conclusion This study highlights that while most mothers possess moderate knowledge regarding the prevention of home accidents among toddlers critical gaps remain particularly in drowning prevention. Enhancing educational efforts and integrating safety education into routine healthcare and community programs are essential to reduce the incidence of preventable home accidents among toddlers thereby safeguarding their health and wellbeing.
ANALYSIS OF THE IMPACT OF NATURAL HAZARDS ON TOURISM ON THE LEFT BANK OF LAKE IZVORU MUNTELUI (NORTH-EASTERN ROMANIA)
Authors:   Alexandru Ioan Cuza University of Iaşi, Faculty of Geography and Geology, Bd Carol I 20A, 700505 Iaşi, Romania, CIMPOEȘU Maria Cristina , CODRU Ionuț Costel ,   Alexandru Ioan Cuza University of Iasi, Research Center with Integrated Techniques for Atmospheric Aerosol Investigation in Romania, RECENT AIR, Laboratory of interdisciplinary research in geo-chemistry of rural areas, Environmental Quality Monitoring Station for Geographic Research, 707290 Madarjac, Iasi, Romania, GROZAVU Adrian ,   Alexandru Ioan Cuza University of Iaşi, Faculty of Geography and Geology, Bd Carol I 20A, 700505 Iaşi, Romania
Published: February 2025

One of the areas with great touristic potential in Romania’s mountains is Izvoru Muntelui Lake (Neamt county) from the western slopes of the Stânișoara Mountains in the Eastern Carpathians. The area is remarkably picturesque in terms of both the natural surroundings and history, including traditions, folklore, and ethnography. Nevertheless, the region is exposed to natural risk phenomena such as floods, landslides, crumbling, etc., which can affect different economic fields, including tourism. The present study aims to analyze the relationship between this zone's natural hazards and tourism activities and their impact. Our approach is based on quantitative and qualitative analysis, interview and questionnaire techniques, but also on literature review, field research, statistics, overlay and spatial mapping of data using GIS techniques and critical interpretation of results through mathematical statistics using Covariance Product of Deviations from the mean and the Bravais-Pearson linear correlation coefficient to measure the intensity of the interdependence between the degree of damage to the road infrastructure and the tourist infrastructure. The results show that the landslides significantly impact the public infrastructures between Poiana Teiului and Bicaz, heavily affecting the national road DN15. A total of 73 impact points were inventoried, representing sections of roads and road infrastructure elements affected by landslides. At the same time, the analysis of the responses to the questionnaire revealed that natural hazards, especially landslides and floods, are perceived as a threat by most tourism operators in the area. The classification of the vulnerability of tourism infrastructure into four categories (low, medium, high, and very high), based on susceptibility maps, has led to the determination of vulnerability to landslides, revealing the following findings: four accommodation units have a medium vulnerability index, two have a high vulnerability index, and one records a very high vulnerability index. It is highlighted that an accurate perception of natural hazards can contribute to increasing the awareness and preparedness of vulnerable people, thus increasing the resilience of present and future generations.
THE ROLE OF PHYTOHORMONES IN PHYTOREMEDIATION USING REED
Authors:   Department of Environmental Engineering, Faculty of Mining and Geology, VSB-Technical University of Ostrava, tř. 17 listopadu 2172/15, Ostrava, Czech Republic, KOČÍŘOVÁ Jana ,   Department of Chemical Biology, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc, Czech Republic, NOVÁKOVÁ Jana ,   Department of Environmental Engineering, Faculty of Mining and Geology, VSB-Technical University of Ostrava, tř. 17 listopadu 2172/15, Ostrava, Czech Republic;, PLAČKOVÁ Lenka ,   Laboratory of Growth Regulators Palacký University & Institute of Experimental Botany AS CR, Šlechtitelů 27, Olomouc, Czech Republic, MELČÁKOVÁ Iva ,   Department of Environmental Engineering, Faculty of Mining and Geology, VSB-Technical University of Ostrava, tř. 17 listopadu 2172/15, Ostrava, Czech Republic;, HEKERA Petr ,   Department of Ecology and Environmental Sciences, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc, Czech Republic;, STALMACHOVÁ Barbara ,   Department of Environmental Engineering, Faculty of Mining and Geology, VSB-Technical University of Ostrava, tř. 17 listopadu 2172/15, Ostrava, Czech Republic;, ANDRÁŠ Peter ,   Faculty of Natural Sciences, Matej Bel University, Tajovského 40, 974 01 Banská Bystrica; Slovakia;, DOLEŽAL Karel ,   Department of Chemical Biology, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc, Czech Republic;     Laboratory of Growth Regulators Palacký University & Institute of Experimental Botany AS CR, Šlechtitelů 27, Olomouc, Czech Republic
Published: February 2025

Salinity is a global problem and salinity areas are constantly increasing because of poor-quality irrigation systems containing high concentration of dissolved salts, salt penetration, and water pollution. This study deals with the phytoremediation of salts from mine water using phytohormones auxin 1-naphthylacetic acid (NAA) and cytokinin (m-topolin) at a concentration 10-5 mol/l and common reed (Phragmites australis). The reed plants collected at the Lazy Mine were tested for their ability to accumulate salts from the surrounding mine waters. The experiment was carried out under controlled and controllable conditions in a phytotron. The hypothesis to be tested was a positive effect of phytohormones on the ability of the common reed to better accumulate salts from mine wastewater. The results show that the application of phytohormones in the long-range period, especially auxin, at a concentration of 10-5 mol/l could have a positive effect on the ability of reeds to accumulate salts from mine waters.
Hamstrings and Quadriceps Weaknesses Following Anterior Cruciate Ligament Reconstruction Persist Up to 6 Months After Return-to-Sport: An Angle-specific Strength Analysis
Authors: Hagen Michiel , Vanrenterghem Jos , Van den Borne Yves , Diaz Maria A. , Verschueren Sabine , Robinson Mark A. , Smeets Annemie
Published: February 2025

BACKGROUND

Hamstrings and quadriceps strength recovery and restoration of the hamstrings-to-quadriceps ratio (H/Q ratio) is a major concern after anterior cruciate ligament reconstruction (ACLR). Recently, moment-angle profiles and angle-specific H/Q ratios are receiving increasing interest.

PURPOSE

The first objective of this study was to investigate moment-angle profiles and angle-specific H/Q ratio profiles in athletes with ACLR at the time of RTS. The second objective of this study was to assess whether strength asymmetries identified at the time of RTS, persist after six months.

STUDY DESIGN

Case-Control study

METHODS

Twenty athletes who had undergone ACLR performed isokinetic strength tests for concentric knee flexion and extension (60°/s) at RTS, and three and six months later. Twenty controls were tested once. T-tests were used to compare strength differences between 1) ACLR athletes and controls and 2) the injured and uninjured leg of the ACLR athletes. Finally, to assess strength deficits over time, two-way ANOVAs were used.

RESULTS

Angle-specific analyses and peak moments showed lower hamstrings strength in the injured leg of ACLR athletes compared to their uninjured leg at RTS. Furthermore, angle-specific analyses showed a lower hamstrings strength and H/Q ratio in the injured leg compared to controls at larger knee flexion angles. The latter deficit was not identified with a peak-based analysis. The asymmetries identified at RTS did not change over the six months following RTS.

CONCLUSIONS

Athletes with ACLR show strength deficits and asymmetries that persist even six months after RTS. As some asymmetries may go undetected by peak-based analyses, angle-specific analyses are recommended.

LEVEL OF EVIDENCE

Level 3b
Ulnar Collateral Ligament Hybrid Reconstruction Surgery & Rehabilitation in the Overhead Athlete
Authors: Meister Keith M , Evans Daniel , Wilk Kevin E , Arrigo Christopher A
Published: February 2025

Injuries to the ulnar collateral ligament (UCL), have become increasingly prevalent among overhead-throwing athletes, especially baseball pitchers. From 2011 to 2023, UCL injuries were the most common injury in Major League Baseball (MLB). Contributing factors include high pitching velocity, fatigue, overuse, and year-round pitching. Research indicates that 25% of MLB pitchers and 14% of Minor League pitchers have undergone UCL surgery, with these numbers steadily rising. After traditional UCL reconstruction, 83% of athletes return to the same or higher levels of play. While the success rate for UCL

surgery is high, revision surgeries are becoming more frequent, with mixed outcomes. This underscores the need for improved surgical techniques and rehabilitation strategies. The hybrid UCL reconstruction technique presents a reliable and effective solution for treating UCL injuries, combining the benefits of autogenous grafting with internal brace augmentation. Current research, however, lacks focus on the surgical technique and rehabilitation following UCL hybrid surgery. Achieving successful outcomes with this procedure relies on a collaborative approach, from surgery to rehabilitation with adherence to the rehabilitation protocol and throwing program. Full recovery typically requires 12-14 months, depending on the athlete’s level of play. With over 400 successful surgeries to date, this technique has proven to enhance stability and facilitate recovery, particularly in elite-level throwing athletes. The purpose of this paper is to describe this new surgical technique and its associated rehabilitation programs, emphasizing the importance of rehabilitation under the guidance of a rehabilitation professional experienced with overhead athletes.

Level of Evidence: 5
GESTÃO ESTRATÉGICA DE RECURSOS HUMANOS EM INSTITUIÇÕES DE ENSINO: DESAFIOS E OPORTUNIDADES
Authors: Lopes Gabriel César Dias
Published: February 2025

Introdução: A gestão estratégica de recursos humanos em instituições de ensino tem se tornado um tema relevante, impulsionado por inovações tecnológicas e mudanças organizacionais. Estudos recentes enfatizam a necessidade de alinhar as práticas de RH às metas institucionais, promovendo um desempenho superior. Pesquisadores como Maditheti (2017) e FITA (2017) destacam a importância da tecnologia e da gestão estratégica para a vantagem competitiva, enquanto outros autores exploram o impacto das práticas de RH no desempenho organizacional.
 
Referencial Teórico: A literatura revisada discute como as tecnologias digitais estão transformando o setor de RH, automatizando processos e melhorando a eficiência. Maditheti (2017) propõe um framework para adoção de tecnologias digitais, enquanto FITA (2017) argumenta que a gestão eficaz de pessoas é essencial para a sustentabilidade organizacional. Petrovic et al. (2018) abordam a relação entre práticas de RH e desempenho, destacando a importância da retenção de talentos e recompensas motivacionais.
 
Resultados e Discussão: Estudos demonstram que a gestão estratégica de RH impacta diretamente a produtividade e a retenção de talentos. Modelos como o de Zakarija et al. (2021) sugerem sistemas de GRH adaptáveis às necessidades do ensino superior. Entretanto, desafios incluem a necessidade de um equilíbrio entre automação e humanização das relações de trabalho.
 
Implicações da Pesquisa: A pesquisa destaca a relevância da integração de tecnologia e estratégias de RH para otimizar a gestão de pessoas em instituições de ensino, propondo soluções que aumentam a eficiência e a qualidade educacional.
 
Originalidade/Valor: O estudo contribui para a compreensão da gestão de RH no setor educacional, fornecendo insights sobre o impacto das estratégias tecnológicas e a necessidade de adaptação constante.
Realidade virtual durante a cateterização intravenosa periférica: perspectiva da criança e do responsável
Authors: Gomes Vitória Carolini , Moura Jefferson Wildes da Silva , Souza Sabrina de , Silva Emanuella Soratto da , Anders Jane Cristina , Pina Juliana Coelho , Rocha Patrícia Kuerten
Published: February 2025

Objetivo: Conhecer a percepção da criança e seu responsável quanto ao uso dos óculos de  realidade virtual na inserção do cateterismo intravenoso periférico em uma Emergência Pediátrica. Métodos: Pesquisa descritiva, exploratória e qualitativa, realizada entre abril e setembro de 2022 na Emergência de Hospital Público Infantil do sul do Brasil. 12 crianças entre 4 e 12 anos de idade e seus respectivos responsáveis compuseram a amostra. A coleta dos dados ocorreu em três etapas: 1) Convite para participação na pesquisa; 2) Sessão de brinquedo terapêutico instrucional com óculos de realidade virtual; 3) Procedimento de cateterismo intravenoso periférico. A análise dos dados ocorreu pela análise dedutiva e aplicação das Escalas DIVA, OSDB e FPS-R. Resultados: Participaram predominantemente crianças do sexo masculino, com sete anos de idade, acompanhados pelas mães. Todas as crianças tinham boas chances de sucesso na primeira tentativa do procedimento pela Escala DIVA; a realidade virtual corroborou para comportamento colaborativo segundo Escala OSDB; e apenas uma criança sentiu a pior dor pela Escala FPS-R. Os dados qualitativos foram categorizados em: antes, durante e após o procedimento. Conclusão: A realidade virtual é efetiva na redução de sentimentos negativos e atenua respostas físicas, psicológicas e emocionais associadas ao cateterismo intravenoso periférico.
Interactive Smart Book Design Based on Augmented Reality with Constructivism Approach in Introduction to Management Course
Authors: Kholifah Siti
Published: February 2025

In Indonesia, there are no augmented reality-based management economics textbooks yet, most of them are still ordinary printed management economics books. In the previous introductory management course book, it was still a regular printed book, there was no touch of augmented reality technology so that the product of the introductory management course was still simple, then after conducting interviews with the lecturers of the introductory management course, an interactive smartbook based on augmented reality with a constructivist approach will be developed in the introductory management course using the ADDIE model, The research method uses the ADDIE model which is implemented holistically from the analysis, design, development, implementation and evaluation stages, and has been assessed by the validation of learning media experts by 98% and learning material experts by 87.5%, then an interesting introductory management book was produced with its augmented reality and was accepted by students with an assessment score of 92.75% meaning that this interactive smartbook product is very suitable for use in introductory management learning.
Error patterns in student translations: A study of grammatical issues in higher education
Authors: Galuh Muhammad
Published: February 2025

The importance of learning English has grown significantly in response to its role as a global means of communication. Mastery of English, particularly its grammatical aspects, is essential for effective communication and is often developed through formal education, such as university programs. This study examines the grammatical competence of undergraduate English Literature students during the 2022/2023 academic year, as reflected in their translation texts. The study analysed 11 translation texts selected from the population using Corder’s superficial basis error classification framework, encompassing four types of errors: omission, addition, selection, and ordering. The classified data were further analysed using general English grammar theories. The findings reveal significant grammatical errors in the students' translations: 49 errors of omission (48%), 7 errors of addition (7%), 40 errors of selection (30%), and 5 errors of ordering (5%). These results highlight specific areas of grammatical difficulty faced by students, offering insights into the need for targeted instructional strategies to improve their grammatical proficiency. This research underscores the importance of error analysis in enhancing the quality of English language education in higher learning institutions.
Benefits and challenges of authentic listening materials and how they can be used for teaching listening
Authors: Ikhtiari Salma
Published: February 2025

This article attempts to discuss the benefits and problems that may arise in using authentic listening materials, and how they can be utilized in enhancing students' listening skills. One of the influencing factors for successful learning in listening classes is materials which can give new information and knowledge to eventually enable students to learn and improve their skills. Teachers as classroom managers are required to choose materials that are suitable to their students as well as challenging and interesting for them to want to learn. Authentic listening materials such as movies, speeches, talks, interviews, news and some others can be alternatives other than ready-to-use materials offered by many course books. For one thing, students can get a wide range of these authentic materials for free. They are usually available on the internet free of charge. These materials also contain authentic language used by native and non-native speakers, which can be used as listening exposure, learning input and communicative activities for students. Audio-visual materials are definitely interesting and motivating, too. On the other hand, these materials, which widely vary in numbers, levels of difficulty, topic as well as other values, require careful consideration to select, and this may take extra time and thinking, not to mention the languages as well as the contents that may not be suitable with the syllabus. Therefore, adaptation, even manipulation, may be made to these authentic materials to be used in listening classes so that students can get what they need in order to learn, especially in gaining sufficient listening skills.
Teacher competence test in Indonesia: Is it a need or a demand?
Authors: Emma Maramis Sofia
Published: February 2025

This study explores the Teacher Competence Test (TCT) and how it is designed to enhance teacher competence. Its implementation has raised concerns about its alignment with its stated objectives. Critics argue that certain aspects of the TCT lack validity in assessing and fostering professional development. The test has been criticized for potentially violating constitutional principles and undermining the core nature of professional assessment by focusing on rigid, standardized measures rather than comprehensive evaluations of teaching practices. This paper explores the fundamental principles and objectives of the TCT, highlighting the controversies surrounding its design and execution. It examines the broader implications of such assessments on the teaching profession in Indonesia and their alignment with global best practices. To provide a comprehensive perspective, the study compares the TCT with similar teacher assessment systems in other countries, analysing their approaches to balancing standardization with individual teacher development. The findings suggest that while the TCT seeks to promote accountability and competence, its current framework may require significant revisions to support teacher growth better and align with constitutional and professional standards. By addressing these issues, this study aims to contribute to the ongoing discourse on improving teacher assessment methods in Indonesia and offers recommendations for creating a more effective, equitable, and professional competency evaluation system.
The impact of peer feedback in an EFL writing class using blogs as a medium
Authors: Diwata Samuel
Published: February 2025

People nowadays are getting addicted to using the internet, especially blogs. Then, this phenomenon inspires the English lecturers to use blog as one of the media to teach writing in an EFL class. This research, therefore, discusses the students' experience of writing using blogs. Here, the blog is used by the students to post their writing assignments based on lessons and discussions in the classroom as well as provide and receive feedback. The qualitative research method is employed while carrying out the research. Data are mainly gathered through students' writings posted to their blogs, peer feedback questionnaires and interviews. The research reveals that 95% of students in the class agree that posting their writings on a blog is an interesting thing to do, and 93% argue that providing and receiving feedback helps them to revise their writing, mainly in the case of grammar and vocabulary. It shows that the experience in writing using blogs and interactions between students is able to enhance their writing abilities. Moreover, the chance to revise their writing is the developing process that can build their motivation and confidence. In the end, it is hoped that this research might inspire English teachers to implement a blog peer feedback process and design suitable activities in an EFL writing class.
Digital Collaborative writing: Challenges and opportunities
Authors: Halimah Siti , Faisal Yazid Mustafa
Published: February 2025

In the current era of rapid technological advancements, educators have access to a wide range of digital tools and applications that facilitate collaboration. These tools enable teachers to share ideas, develop lesson plans together, implement teaching strategies, and evaluate educational outcomes in partnership with their colleagues. This paper explores the use of collaborative writing applications, emphasizing their potential to enhance teamwork and productivity among educators. By analysing the outcomes of collaborative efforts, the study aims to demonstrate effective strategies for leveraging these technologies in the context of professional collaboration. The findings provide valuable insights into how technology can streamline the process of co-authoring educational materials, ultimately contributing to improved teaching practices and professional development.
Critical learning method in writing class: What do learners think about it?
Authors: Izmah Saeful , Ikmalia Larasati , Syaifullah Burhan
Published: February 2025

The change of paradigm from "teaching" to "learning': facilitated with critical learning method (CLM) is able to create more meaningful learning environment and experience for university students. However, there might be rejections from teachers, students, or administrators. The current research focuses on students' problems, especially those who joined Writing II class at the English Department of Hasanuddin University. This study was conducted as action research. Two CLM lesson plans were developed and applied in the writing class, and the class interactions were videotaped. The videos were shown to respondents at the end of the semester. Respondents' perceptions were investigated by using free writing and interview techniques. The results revealed that the respondents had positive perception about CLM. However, lecturers need to consider the different levels of learners' proficiency, and to provide relevant reading assignments prior to each session of writing activities.