bluuebunny/crossref_metadata_2025 huggingface dataset:
Rancang Bangun Aplikasi Pengelolaan Keuangan Berbasis Android Menggunakan Framework React Native
Authors: Harry Soepandi , Wijonarko Dwi , Afif Hasnan
Published: January 2024

Financial management application is an information system that facilitates the organization to manage financial data for related fields so that it can help complete activities in the financial sector, especially for the process of recording and financial statements quickly. The aim is to realize the Implication of a android-based Financial Information System to support the presentation of information in the decision-making process by the leadership, as well as the finance department. The method used is analytical methods and design methods. The design method is making the implementation of information systems, database design and financial data analysis. The method of analysis is done by using observation and interview techniques, literature studies, direct surveys at de.Blado Coffee & Tea by interviewing related people to complete the information needed. The end result of implementing a android-based financial information system is used to simplify and speed up data access and provide the leadership with full access to data without processing operational data. With the establishment of information systems, structured and integrated data can be produced well as input for management in the decision making process.
INNOVATION AND CHANGES IN THE DIDACTIC SPACE
Authors:   Ph.D., Candidate, Architecture, Built Environment, and Construction Engineering Department (ABC), Politecnico di Milano, Milan, Italy, Martinazzo Francesco
Published: January 2024

In Italy, the theme of the school, and more generally of education in the broadest sense, already in turmoil before the epidemic, seems to be exploding today in all its urgency, both because of the instances - above all pedagogical - of transformation brought by the pandemic itself (which from this point of view has acted as a catalyst), and because of the uncertain consequences of a building heritage that now largely needs to be restored, because it is architecturally and technologically inadequate. This has led to the structuring of a literature review that takes into account two main time spans: on the one hand, that of the 1960s-1970s (often called "the golden age of school"), investigated through the international architectural journals of that period, where the typology-technology problem emerges strongly; on the other hand, the selection (through Scopus, WoS, etc.) of current or recent studies and pedagogical experiences related to new technologies. The criterion for the choice of case studies is therefore based on their propulsive potential in relation to today's transformation needs, seeking to consider the school as an organism and not merely as a set of functional parts (as much current literature does).
Loss Analysis in Bread Production Process Using Material Flow Cost Accounting Technique
Authors:   Student, Master’s Degree Program in Industrial Engineering, Faculty of Engineering,  Chiang Mai University, Chiang Mai, Thailand, Yoddee Bunyaporn , Chompu-inwai Rungchat ,   Ph.D., Department of Industrial Engineering, Faculty of Engineering, Chiang Mai University,  Chiang Mai, Thailand
Published: January 2024

The case study factory manufactures a range of bread and bakery products for distribution in the North of Thailand. Losses from the production process were recently discovered, which besides being lost costs, also impacted the environment. This research is conducted under the concept of Material Flow Cost Accounting (MFCA) to analyze the losses from each process of the case study bread factory. This is to pinpoint where most of the losses occur and suggest methods for future improvement. This research is conducted with the principle of Plan Do Check Action (PDCA). The “Plan” was to determine a target product, which in this case was raisin bread, as it accounted for the largest proportion of production. Subsequently, a study was conducted of the production process, and a scope under the “Do” stage of the procedure was determined. Input and output factors were identified for each Quantity Center (QC) in both physical units and financial units. Subsequently at the “Check” stage, an analysis of costs was conducted for each QC with the MFCA technique. This was divided into positive product, meaning costs generating revenue, and which were manifest in the product, and negative product, which were costs not generating revenue and were losses from each production stage. Finally, at the “Action” stage, negative products were ranked using Pareto diagram to identify and evaluate opportunities for improvement. The research found that the total costs to produce one production lot of raisin bread were 2,935.55 THB, which were divided into materials costs of 2,270.79 THB (77.35%), system costs of 500.30 THB (17.04%) and energy costs of 164.46 THB (5.60%). Overall, negative product was 25.19%, of which negative product in material costs was 19.41%. This negative product was wastage and losses from dough and fillings being deposited in the machinery, and the failure of packaging films when they were being installed in the packing machine. It was also found that negative materials costs arose maximum in the QC of packing. The conclusions from this research are that it has informed about losses arising in the production process and evaluated them in the form of costs, which should help in proposing methods to reduce this wastage in the future.
A relação entre as emoções de rivalidade e as categorias do desejo em Aristóteles
Authors: Barreiro Mateus , Furlan Marta
Published: January 2024

Na filosofia de Aristóteles, o sentimento de amizade apresenta uma ambivalência com as emoções de rivalidade (philotimia) como a cólera (orgê) e a emulação (zêlos). Neste sentido, este artigo tem como objetivo principal refletir sobre os aspectos emocionais que envolvem a noção de amizade, visando aprofundar a relação entre as emoções de rivalidade e as categorias do desejo em Aristóteles. A produtividade dessas reflexões, aponta que o modo como as diversas relações sociais e a construção do conhecimento desenvolvido, também são emocionais, fato que expõem como condição necessária para o desenvolvimento de aspectos vinculados a formação humana.
Indústria cultural e formação humana
Authors: Primo Samoel Cordeiro de Souza , Neuvald Luciane
Published: January 2024

Este texto aborda o paradoxo entre a indústria cultural e a formação humana, com base na teoria crítica. O texto utiliza uma metodologia bibliográfica, discutindo temas como educação, formação, semiformação, indústria cultural, capitalismo e emancipação. O objetivo é debater como a indústria cultural interfere na formação dos indivíduos. A contribuição dos processos educativos para o desenvolvimento da civilização é destacada, enfatizando a importância da criticidade e autorreflexão para evitar a barbárie. Os fundamentos da teoria crítica ressaltam a necessidade de um pensamento filosófico que oriente o sujeito para o esclarecimento. A educação para a emancipação é considerada a mais eficaz para a formação humana em uma sociedade explorada pelo capital. O estudo reconhece que novas questões surgirão, indo além dos limites desta pesquisa.
Os salesianos e o processo civilizador por meio da educação no antigo sul de mato grosso
Authors: Barbosa Alana de Oliveira , Oliveira Elizandro Chaves de , Cazavechia William Robson
Published: January 2024

O presente artigo analisa o crescimento das instituições escolares salesianas no Antigo Sul de Mato Grosso no final do século XIX e início do XX e o ideal de um processo civilizador educacional, empreendido pela Igreja Católica, protagonizado pela congregação salesiana a qual atuou para assegurar prerrogativa educacionais ao passo que o Estado brasileiro laicizava-se. Essa análise terá como suporte bibliográfico a obra de Riolando Azzi (1982) que em sua obra Os salesianos no Brasil à luz da História, destaca o papel exercido pelo Manual Civilizador dos salesianos. Como aporte teórico, destacamos a obra de Norbert Elias (1994), O processo civilizador.
Progress towards a more sustainable and equitable food system in Brazil?
Authors: Ikematsu Priscila , Maurin Cristelle
Published: January 2024

Introduction: Brazil’s agri-food sector, traditionally being a low productivity sector, has evolved towards significant investment in technology-driven large-scale agribusiness, making Brazil a major food exporter. An increase in intensive large-scale agriculture production, while benefiting Brazil’s economy and export revenues, has also resulted in significant social and environmental externalities. With the aim to improve food security and more equitable access to food, Brazil’s federal government has intervened with a range of policies and initiatives to eliminate hunger and incentivize more sustainable practices for improved environmental outcomes. Objective: The paper provides an overview of the agri-food policy landscape, and policy innovations since the early 2000s intending to drive a transition towards a more sustainable and equitable agri-food system. Results and Discussion: It also highlights the challenges in implementing policies and programmes in the context of Brazil’s agrarian structures, vested interests and political conflicts surrounding the allocation of public assets. Successful implementation will require further innovation, collaboration and inclusive partnerships to foster food system transformation pathways towards the achievement of the Sustainable Development Goals.
KONTRIBUSI INISIASI MENYUSU DINI DAN DUKUNGAN SUAMI PADA RIWAYAT ASI EKSKLUSIF BAYI UMUR 6 SAMPAI 12 BULAN
Authors: Hasanah Ika Putri , Nindya Triska Susila
Published: January 2024

World Health Organization (WHO) and United Nations Children’s Fund (UNICEF) provide recommendations for exclusive breastfeeding until the child aged 6 months and continued until the child aged 2 years. Exclusive breastfeeding has many benefits, however its practice remains low which can be caused by several factor, such as early initiation of breastfeeding and the husband support. This study aims to analyze the relationship between early initiation of breastfeeding and husband suppport with the exclusive breastfeeding history for infants aged 0 to 6 months old in the area of Brambang Public Health Center, Jombang district. The study design was cross sectional. The sample was mothers with infants aged 6 to 12 months as much as 77 respondents in area of Brambang Public Health Center, Jombang district. Subjects were taken using simple random sampling. Information in the study obtained through direct interviews with questionnaires to mothers. Chi-Square test was used to analyze the relationship between early initiation and the husband support with exclusive breastfeeding history. The result showed that there was a relationship between early initiation of breastfeeding (p=0,000) and husband support (p=0,000) with exclusive breastfeeding history. The result showed that early initiation of breastfeeding and husband support could increase the tendency of exclusive breastfeeding. It suggested to improve the early initiation of breastfeeding in maternity hospitals and improve husband support by involving husband during breastfeeding counseling.Keywords: Early initiation of breastfeeding, exclusive breastfeeding history, husband support
ASUPAN DAN KECUKUPAN GIZI ANTARA REMAJA OBESITAS DENGAN NON OBESITAS
Authors: Loliana Nadia , Nadhiroh Siti Rahayu
Published: January 2024

Nutrition issues in adolescents arise because of inappropriate dietary habit, causing an imbalance between nutritional  intakes and the recommended dietary allowances. The prevalence of obesity in adolescents increased within the last 30 years. The percentage of adolescents aged 12-19 years who were obese increased from 18,4% in 2009-2010 to 20,5% in 2012. Obesity occurred because of behavior and habit of adolescent who consume high calorie food excessively. The aim of this research was to analyze the difference of intake and nutritional adequacy between obese and nonobeseadolescents. This study was an analytical observational research with cross sectional design. The sample was 46 Senior High School students that divided into 23 obese and 23 non obese adolescent groups chosen by simple random sampling. The obesity data was obtained from the results of anthropometric measurements, while intake and nutritional adequacy were obtained from 2x24 hours food recall form. Mann Whitney test was used to analyze the difference between variable. The research revealed that there was a difference of energy intake, carbohydrates, protein, and fat with p-value 0,01, 0,00, 0,038 and 0,018 respectively, and nutritional adequacy of energy, carbohydrates, protein, and fat with 0,02, 0,00, 0,017 and 0,018 respectively between obese and non-obese adolescents. It can be concluded that there is a difference of intake and nutritional adequacy between obese and non-obese adolescents. Providing information and education about obesity, it risks, and healthy diet are recommended to prevent obesity.Keywords: intake, nutritional adequacy, obesity, adolescents
KETAHANAN PANGAN DAN COPING STRATEGY RUMAH TANGGA URBAN FARMING PERTANIAN DAN PERIKANAN KOTA SURABAYA
Authors: Anggrayni Fika Mayrlina , Andrias Dini Ririn , Adriani Merryana
Published: January 2024

Rapid urbanization in urban areas causes dissimilarity of food access in each household. It is become one of urban food security problem. Urban farming is a strategy to improve food access in urban areas. The purpose of this study was to analyze the difference in food security and coping strategy of agriculture and fisheries urban farming households. This observational study used a cross-sectional design. A sample of 62 households were divided into 2 groups: agriculture and fisheries urban farming households. Food security was assessed by United States Household Food Security Survey Module (US-HFSSM) questionnaire while coping strategy was assessed by Reduced Coping Strategy Index (RCSI) questionnaire. The difference of household food security and coping strategy in both groups was analyzed by Chi square test. A total of 64,7% household in agriculture group were in food secured, while 75% households in fishery group were in food insecure with severe hunger degrees. There was no difference of household food security between agriculture and fisheries urban farming group (p = 0,255), although two groups had different in food security status. Most of agriculture urban farming household has RCSI score <14 (65,6%), while the majority of fishery urban farming household has RCSI score ≥ 14 (66,7%). There was a difference of coping strategy between agriculture and fishery urban farming household (p = 0,021). Agriculture urban farming households were secured and rarely do coping strategy compared to fishery urban farming households. Government programs to improve food security should be more focused on groups of fishery urban farming households.Keywords: coping strategy, food security, household, urban farming
AS CATEGORIAS COMO INVARIANTES ONTOLÓGICOS DA ORDEM SISTEMÁTICA DO DISCURSO EM LIMA VAZ (I)
Authors: Aquino Marcelo Fernandes de
Published: January 2024

Esta é a primeira parte de uma trilogia cujo foco é a Antropologia Filosófica de Lima Vaz. A mediação que a Antropologia Filosófica desempenha entre Metafísica e Ética é o pressuposto da hermenêutica vaziana feita a partir da relação entre categorias filosóficas e ordem sistemática do seu discurso.

Palavras-chave: Antropologia Filosófica. Metafísica. Ética. Sistema. Discurso. Inteligibilidade. Linguagem. Ser.
ROSTO, ÉTICA E ALTERIDADE. POR UM PENSAMENTO OUTRAMENTE TRÁGICO EM EMMANUEL LEVINAS
Authors: Junior Nilo Ribeiro
Published: January 2024

A investigação que se segue tem como escopo evidenciar os motivos que permitem (re)posicionar a filosofia da alteridade de Emmanuel Levinas para além de sua então reconhecida vinculação à fenomenologia. Trata-se de situá-la, paradoxalmente, no rol de um pensamento de corte trágico graças à oposição ao romantismo do Idealismo da filosofia moderna. Entretanto, como o foco da reflexão do autor se volta explicitamente para a ética sui generis que brota da visceral relação/interpelação advinda do contato/Dizer de um Rosto humano que não pode ser reduzido ao Logos, urge enfatizar, por um lado, certa aproximação de seu pensamento tanto da genealogia da moral em Nietzsche como da ética originária ontológica em Heidegger. Por outro lado, pretende-se apontar para certo distanciamento desse outro niilismo que se consolida em torno da ética da alteridade em relação ao pensamento dos referidos filósofos trágicos. Afinal, a ética do Rosto visa pensar outramente a transmutação de valores que já não tem como objeto a vontade de potência e/ou o cuidado da Existência pelo ser humano. Graças à radical (alter)ação da condição humana provocada pelo dizer da proximidade do Outro-próximo, desponta nesse cenário uma subjetividade que se caracteriza por uma autêntica maternagem e por uma substituição de outrem. Tendo-se, pois, em mente essas constatações, procurar-se-á descrever os traços indeléveis de certo niilismo disruptivo presente na gênese da filosofia trágica do Rosto do outro.
Palavras-chave: Alteridade. Niilismo. Ética. Filosofia. Linguagem.
HINGES, THE EPISTEMOLOGY OF RELIGION AND THE PROBLEM OF RELIGIOUS DISAGREEMENT
Authors: Salvatore Nicola Claudio
Published: January 2024

In this paper, I propose and defend an account of the nature and the epistemology of religious beliefs loosely inspired by Wittgenstein´s remarks on the structure of reason and on the nature of religious beliefs. I argue that following and developing his account we can not only make a strong case for the prima facie rationality of religious beliefs but also, and more importantly, cast new light on the epistemology of religious disagreement.

Keywords: Wittgenstein. Hinges. Epistemic warrant. Religious disagreement.
O PROBLEMA ESTRUTURAL COM O DILEMA METAÉTICO DE STREET: UMA PROPOSTA A PARTIR DE ALVIN PLANTINGA
Authors: Almeida Frederico Soares de , Peixoto Matheus Dabnei Ferreira
Published: January 2024

Argumentos evolutivos debunking (AEDs), de maneira geral, têm o objetivo de danificar o status epistêmico de um domínio de crenças ao se apelar para suas origens evolutivas. No horizonte da metaética, AEDs normalmente são direcionados a teses realistas da moralidade e consistem essencialmente em afirmar que se nossas crenças morais sofreram influência significativa de pressões seletivas durante nossa história evolutiva, então se segue algum tipo de ceticismo moral. Um dos argumentos paradigmáticos articulados nessa direção é o Dilema Darwiniano de Sharon Street. Nossa proposta no artigo presente é colocarmos o argumento evolutivo contra o naturalismo (AECN) de Alvin Plantinga – um AED oriundo da filosofia analítica da religião – como possível resposta ao problema do ceticismo moral proposto por Street. Dessa forma, Plantinga pontua que considerações evolutivas tomadas dentro do framework do naturalismo ontológico acarretam em um conflito epistêmico para o sujeito que deseja manter em seu sistema doxástico tanto a crença na teoria contemporânea da evolução, quanto a crença no naturalismo ontológico. Argumentamos, a partir dessa questão, que o Dilema Darwiniano sofre de um problema estrutural por causa do seu comprometimento com a ontologia naturalista, o que faz com que o dilema se generalize em seu escopo e afete, de maneira nociva, crenças não-morais, se tornando autorreferencialmente incoerente.
Palavras-chave: realismo moral. Naturalismo. Crenças.
Modeling the Differential Effect of Prescribed Fire on Multi-Vector Tick-Borne Tularemia Disease
Authors: Agusto Folashade B. , Atsu Joshua , Kwarteng-Adjei Dorothy , Lamptey-Mills Daniel , Osei Samuel A.
Published: January 2024

Tularemia is a zoonotic disease caused by {\it Francisella tularensis} bacteria, a gram-negative coccobacillus-shaped bacterium. There are multiple transmission routes of the infection to humans such as consumption of contaminated food or water, handling of infected animals or bites from {\it haematophagous} arthropods (such as ticks, deer flies, or mosquitoes). In this study we focus on transmission via the bites of ticks and developed a deterministic model of ordinary and impulsive differential equations to gain insight in the differential effect of prescribed fire on {\it Demacenta variablis} and {\it Amblyomma americanum} ticks and the prevalence of tularemina. We found that prescribed fire differentially reduce the number of the two ticks with {\it A. americanum} reduced the least compare to {\it D. variablis} subsequently leading to differential increase of tularemia new infected cases in humans and rodents. Our result further indicates that the spatial arrangement of burn against unburn areas may not matter as either arrangement led to fewer ticks and reduction in tularemia transmission when prescribed fire was implemented. The results of this study provide important new understandings of the intricate effect of prescribed fire on tick species, and the dynamics of the tick-borne disease, tularemia disease in this study.
An Improved SMS Security Technique to Avoid Plaintext and Dictionary Attacks
Authors: Ashraf Humaira , Zam Zam Mirza Qurat Ul Ain , Jhanjhi NZ
Published: January 2024

: Digital communication is becoming an integral component of contemporary society and the use of mobile devices is increasing faster than ever. The function of message communication is becoming more popular as for mobile phone users, a short messaging service (SMS) requires an extremely high level of security. Any SMS that enters a person's smartphone must be considered a private affair, with privacy and security safeguarded. This research study found a novel Deoxyribonucleic acid (DNA) Cryptography method that uses a dynamic DNA sequence table to increase security. Cryptography is a popular approach for ensuring the confidentiality of a message. This paper proposed an Efficient Cryptographic Scheme for SMS (ECSS) algorithm to protect texts received from an Android smartphone. ECSS-based encryption has been identified as a novel method of securing information in the form of DNA molecules that employ DNA strands to conceal the information. This Paper provides the DNA cryptography approach for encrypting and decrypting plain texts in this work. The primary goal of ECSS cryptography is to guarantee secrecy when people transfer data across a network. This paper examines DNA Crypto, the distinction between classical cryptography and DNA Data encryption. An Android-based app is created to perform the proposed technique and the results show that the algorithms produce a consistent encryption result in which the length of the message before encryption is always the same as the length of the message after decryption. The suggested security solution has the potential to greatly improve the security of mobile communication. This Paper also provides experimental results for our chat application performance, such as received text message correctness, cipher text, average encryption time and average decryption time. According to the findings/results of this study, the speed of average encryption and decryption of the description is roughly 0.011 and 0.037 sec and prevents plaintext and dictionary attacks.
A Biomechanical Model for Joint Functioning of Neck and Shoulder
Authors: Yurova Alexandra , Gladkov Andrey , Kalinskiy Eugene , Lychagin Alexey , Shipilov Anatoly , Vassilevski Yuri
Published: January 2024

A combination of pain syndromes in the neck and shoulder joints creates a significant burden on the healthcare system and has important social and economic significance. Treatment of these pathologies is often inefficient and can reduce the quality of life for patients. Studying of the relationship between pathological changes in the cervical spine and diseases of the shoulder area is crucial for developing more efficient treatment methods. Biomechanical modeling can be a valuable tool in this research, as assessing muscle function in patients is not always feasible. To our knowledge, there are no open-source biomechanical models for joint functioning of neck and shoulder. The aim of this research is to construct a biomechanical model for neck and shoulder joint functioning and to investigate numerically the work of neck and shoulder muscles during head and arm movements.
Fasting Blood Glucose-Based Novel Predictors in Predicting Prognosis for Pancreatic Neuroendocrine Neoplasms Patients
Authors: Yu Li , Fu Mengfei , Yang Liu , Chen Yang , Chen Xiao , Cao Yanyan , Sun Hui
Published: January 2024

Objective: To explore three novel fasting blood glucose (FBG)-based novel indicators, including FBG-to-albumin ratio (FAR), FBG-to-lymphocytes ratio (FLR), and FBG-to-hemoglobin ratio (FHR), in predicting prognosis and detecting metastasis for patients with pancreatic neuroendocrine neoplasms after resection. Materials and methods: A total of 178 pNEN patients underwent surgical resection were included in this study. Receiver operating characteristic (ROC) curves were used to evaluate the diagnosis values of FAR, FLR, and FHR, and the cut-off values were obtained for further analyses. Univariate and multivariate analyses were conducted to determine the independent predictors. The Kaplan-Meier method was used to evaluate the progression-free survival (PFS) and overall survival (OS) of the pNEN patients. Results: The optimal cut-off values of FAR, FLR, and FHR were 0.17, 2.85, and 0.028, respectively. As for PFS, the area under the curve (AUC) was 0.693 for FAR, 0.690 for FLR, and 0.661 for FHR, respectively. The AUC was 0.770, 0.692, and 0.715 accordingly for OS. The groups with lower FAR, FLR, and FHR were significantly associated with prolonged PFS and OS (p < 0.05). In patients with metastasis, the lower FAR group was correlated with significantly longer PFS and OS (p = 0.022 and 0.002, respectively). The FLR was an independent predictor of PFS in pNEN patients, and the FAR was a predictor of OS. FAR was an independent indicator of PFS in patients with metastasis. Conclusion: Preoperative FAR, FLR, and FHR are effective in predicting the prognosis of pNEN patients and detecting the synchronous metastases.
Comprehensive Co-inhibitory Receptors (Co-IRS) Expression T Cells and Soluble Proteins Predict Ra Pathogenesis and Activity
Authors: Wang Chin-Man , Jan Wu Yeong-Jian , Huang Li Yu , Zheng Jian-Wen , Chen Ji-Yih
Published: January 2024

Co-inhibitory receptors (Co-IRs) are essential in controlling the progression of immunopathology in rheumatoid arthritis (RA) by limiting T cell activation. The objective of this investigation was to determine the phenotypic expression of Co-IRs T cells and to assess the levels of serum soluble PD-1, PDL-2, and Tim3 in Taiwanese RA patients. Co-IRs T cells were immunophenotyped employing multicolor flow cytometry, and ELISA was utilized for measuring soluble PD-1, PDL-2, and Tim3. Correlations have been detected across the percentage of T cells expressing Co-IRs (MFI) and different indicators in the blood, including ESR, high sensitivity CRP (hsCRP), 28 joint disease activity scores (DAS28), and soluble PD-1/PDL-2/Tim3. In RA patients, we recognized elevated levels of PD-1 (CD279), CTLA-4, and TIGIT on CD4+ T cells; TIGIT, HLA-DR, TIM3, and LAG3 on CD8+ T cells; and CD8+CD279+TIM3+, CD8+HLA-DR+CD38+ T cells. The following tests proved to be correlated with hsCRP: CD4/CD279 MFI, CD4/CD279%, CD4/TIM3%, CD8/TIM3%, CD8/TIM3 MFI, CD8/LAG3%, and CD8+HLA-DR+CD38+%. CD8/LAG3 and CD8/TIM3 MFIs are linked to ESR. DAS28-ESR and DAS28-CRP exhibited relationships with CD4/CD127 MFI, CD8/CD279%, and CD8/CD127 MFI, respectively. CD4+CD279+TIM3+% was correlated with DAS28-ESR (p=0.0084, N=46), DAS28-CRP (p=0.007, N=47), and hsCRP (p=0.002, N=56), respectively. In the serum of patients with RA, levels of soluble PD-1, PDL-2, and Tim3 were extremely elevated. CD4+ TIM3+% (p=0.0089, N=46) and CD8+ TIM3+% (p=0.0305, N=46) were correlated with sTIM3 levels; sPD1 levels were correlated with CD4+CD279+% (p<0.0001, N=31) and CD3+CD279+% (p=0.0084, N=30). Co-IRs expressions on CD4+ and CD8+ T cells, as well as soluble PD-1, PDL-2, and Tim3 levels, could function as indicators of disease activity and potentially play crucial roles in the pathogenesis of RA, in accordance to our findings.
Bioelectrical Impedance in Premature Newborns and Its Relationship with Diet Therapy in a Neonatal Intensive Care Unit
Authors: Tortorella Catiuscie Cabreira da Silva , Chao Bárbara Mendes Paz , Rabito³ Estela Iraci , Lima Mônica Nunes , Sarquis Ana Lúcia Figueiredo
Published: January 2024

(1) Background: To estimate resistance, reactance and phase angle values among moderate preterm infants and their variation according to neonatal and maternal characteristics and nutritional intake. (2) Methods: This was a cohort that evaluated 43 moderate preterm infants using bioelectrical impedance analysis. The study variables included resistance, reactance and PA measurements, in addition to classification of nutritional intake. (3) Results: The mean resistance was 602.0+118.2 Ω, reactance was 57.2 Ω (IIQ = 42.6-65.2) and phase angle was 522° (IIQ = 4.1-6.6). Lower resistance values were found in the presence of risky pregnancy (532.2+111.9 Ω vs 650.9+97.9 Ω, p<0.001) and lower reactance values, in the presence of harmful maternal lifestyle habits at both the first (p=0.01) and second assessments (p=0.01). Eight preterm infants were considered to have insufficient nutritional intake (23.5%); 17, sufficient (50.0%) and 9, partially sufficient (26.5%). There was less reactance among preterm infants with insufficient nutritional intake (p < 0.001). (4) Conclusions: The bioelectrical impedance analysis measurements were within the range of values reported in other studies. There was an association between full diet and adequate nutritional intake with higher resistance values, and a lower reactance value was associated with the presence of risky pregnancy and harmful maternal lifestyle.
Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review
Authors: Sivadasan Durgaramani
Published: January 2024

Transdermal drug delivery systems (TDDS) are designed to administer a consistent and effective dose of medication through the patient's skin. These pharmaceutical preparations are self-contained, discrete dosage forms designed to be placed topically on intact skin to release the active component at a controlled rate by penetrating the skin barriers. This medication provides a continuous and prolonged administration of a substance at a consistent rate. TDDS, or transdermal drug delivery system, has gained significant attention as a non-invasive method of administering drugs to vulnerable patient populations, such as pediatric and geriatric patients. This approach is considered easy to administer and helps overcome bioavailability issues associated with conventional drug delivery, which can be hindered by poor absorption and metabolism. TDDS has various advantages compared to conventional methods of drug administration. It is less intrusive, more patient-friendly, and can circumvent first-pass metabolism and the corrosive acidic environment of the stomach that happens when medications are taken orally. Multiple methodologies have been devised to augment the transdermal permeability of diverse pharmaceutical substances. Recent advancements in transdermal drug delivery systems have facilitated the precise delivery of medications to the intended site of action by improving the penetration of drugs through the outermost layer of the skin, known as the stratum corneum, resulting in enhanced drug availability throughout the body. This review seeks to provide a concise overview of the several methods employed in the production of TDDS, as well as their evaluation, therapeutic uses, clinical considerations, and current advancements. These advancements have resulted in the development of intelligent, biodegradable, and highly efficient transdermal drug delivery systems.
Improving Retention in Mental Health and Psychosocial Support Interventions: An Analysis of Completion Rates Across a Multi-Site Trial with Displaced and Host Populations in Latin America
Authors: Fernández Capriles Isabella , Armijos Andrea , Angulo Alejandra , Schojan Matthew , Wainberg Milton L. , Bonz Annie G. , Tol Wietse A. , Greene M. Claire
Published: January 2024

Research on mental health and psychosocial support (MHPSS) interventions with displaced communities has increasingly focused on evaluating implementation, including identifying strategies to promote retention in services. This study examines the relationship between participant characteristics, study setting, and reasons for intervention noncompletion using data from the Entre Nosotras feasibility trial, a community-based MHPSS intervention targeting displaced and host community women in Ecuador and Panama that aimed to promote psychosocial wellbeing. Among 225 enrolled women, approximately half completed the intervention, with varying completion rates and reasons for nonattendance across study sites. Participants who were older, had migrated for family reasons, had spent more time in the study community, and were living in Panamá (vs. Ecuador) were more likely to complete the intervention. The findings suggest the need to adapt MHPSS interventions to consider the duration of access to the target population and explore different delivery modalities including the role of technology and cellular devices as reliable or unreliable source for engaging with participants. Engaging younger, newly arrived women is crucial, as they showed lower completion rates. Strategies such as consulting scheduling preferences, providing on-site childcare, and integrating MHPSS interventions with other programs could enhance intervention attendance.
Development of a Versatile Lipid Core for Nanostructure Lipid Carriers (NLC) Using Design of Experiments (DoE) and Raman Mapping
Authors: Rios Carlos Alberto , Ondei Roberta , Breiktreitz Márcia Cristina
Published: January 2024

In the study, a lipid mixture was developed and optimized using a broad range of excipients of different po-larities. Initially, the excipients were classified according to their behavior in water. Then binary mixtures were prepared using cetyl palmitate (Crodamol™ CP pharma) as the solid lipid. The miscibility between the excipients was evaluated using Raman chemical images obtained by classical least squares (CLS). Based on the results, the excipients Crodamol™ CP pharma (cetyl palmitate, hydrophobic), Super Refined™ DMI (di-methyl isosorbide; hydrophilic) and Super Refined™ Lauryl Lactate (medium polarity) were chosen to com-pose the lipid core. The ideal proportion of these excipients was determined using a Mixture Design and the standard deviation of image histograms as responses. The main goal was to develop a versatile lipid core for ‘brick-dust type of drugs’. After statistical evaluation of the DOE results, the final composition was deter-mined and drugs with different logP (0 to 10) and physiochemical characteristics were evaluated in the opti-mized mixture. The drugs butamben, tacrolimus, atorvastatin calcium and resveratrol presented a homoge-neous distribution in the optimized lipid core, indicating that the core has indeed the capability to be used in NLC formulations of such type of drugs.
The Impact of Atmospheric Cadmium Exposure on Colon Cancer and the Invasiveness of Stents within the Cancerous Colon
Authors: Zhang Shuai , Li Ruikang , Xu Jing , Liu Yan , Zhang Yanjie
Published: January 2024

Background: Inhalation exposure to carcinogenic metals like cadmium (Cd) is a significant global health concern linked to various cancers. However, understanding their precise carcinogenic mechanism remains elusive. Methods: Using the colon cancer (CC) rat model and implanted intestinal stent, exposed them to atomized oxygen and nitrogen (O2/N2) gas containing Cd. Results: Atmospheric Cd intensified inflammation in CC cells, heightening nicotinamide adenine dinucleotide phosphate 1 (NOX1) activity, generating increased reactive oxygen species (ROS). This escalated ROS production triggered abnormal Wnt protein secretion, activating the Wnt/β-catenin pathway, stimulating CC cell proliferation. No discernible body weight effect was seen in CC mice, possibly due to later-stage tumor weight gain, masking rat changes. Cd facilitated colon tumor restructuring and cell migration later. Intestinal stents inhibited superoxide dismutase 1 (SOD1) in CC mice's tumors, with no clear effects on NOX1, SOD2, and catalase (CAT) enzymes. Elevated ROS levels didn't substantially impact Wnt/β-catenin and might slow its imbalance. Stent implantation eased inflammation, reducing CC cell proliferation but induced discomfort in rats, reducing food intake and weight. Conclusion: Cd might partially foster CC tumorigenesis via the ROS-mediated Wnt/β-catenin pathway. The effect of Cd on the invasive effect of intestinal stents in cancerous colon was not significant.
The Resistance of Soybean Variety Heinong 84 to Apple Latent Spherical Virus Is Controlled by Two Genetic Loci
Authors: Ma Tingshuai , Zhang Ying , Li Yong , Zhao Yu , Attiogbe Kekely Bruno , Fan Xinyue , Fan Wenqian , Sun Jiaxing , Luo Yalou , Yu Xinwei , Ji Weiqin , Cheng Xiaofei , Wu Xiaoyun
Published: January 2024

Apple latent spherical virus (ALSV) is widely used as a virus-induced gene silencing (VIGS) vector for function genome study. However, the application of ALSV in soybean is limited by the resistance of many varieties. In this study, the genetic loci linked to the resistance of a resistant soybean variety Heinong 84 was mapped by high-throughput sequencing‒Bulk Segregation Analysis (HTS‒BSA) using a hybrid population crossed from Heinong 84 and a susceptible variety Zhonghuang 13. Results showed that the resistance of Heinong 84 to ALSV is controlled by two genetic loci located on chromosome 2 and 11, respectively. Cleaved amplified polymorphic sequences (CAPS) markers were developed for identification and genotyping. Inheritance and biochemical analyses suggest that the resistance locus on chromosome 2 plays a dominant dose-dependent role, while the other locus contributes a secondary role in resisting ALSV. The resistance locus on chromosome 2 might encode a protein that can directly inhibit viral proliferation, while the secondary resistance locus on chromosome 11 may encode a host factor required for viral proliferation. Together, these data reveal novel insights on the resistance mechanism of Heinong 84 to ALSV, which will benefit for the application of ALSV as a VIGS vector.
First Case of Human Anisakiosis in Greece: Acute Invasive Infection Mimicking Peritoneal Malignancy
Authors: Dinas Sotirios , Diakou Anastasia , Vasiliadis Konstantinos , Chaintoutis Serafeim C. , Massa Eleftheria , Konstantinou George N. , Totsi Albion , Xakis Athanasios , Papavasiliou Christos
Published: January 2024

Consumption of raw and mild processed seafood, in the context of modern western world eating trends, is recognized as a major driver for human fish-borne infections. However, these zoonoses and their unfamiliar risks remain neglected and underappreciated among European diagnosticians. In contemporary Europe anisakiosis is one of the most important fish-borne zoonoses. It is caused by ingesting nematode parasites of the family Anisakidae. The case described herein, is an intestinal and ectopic form of anisakiosis, causing symptoms of subacute abdomen and masquerading as an intraperitoneal malignancy. It is the first anisakiosis case reported in Greece, affecting a young patient who had been repeatedly exposed to the parasite by consuming homemade raw fish. Right hemicolectomy, omentectomy and excision of a descending colon nodule were uneventfully performed. The pathology report confirmed granulomatous tissue with eosinophilic infiltration and parasites that were morphologically and molecularly identified as Anisakis spp. Although challenging, obtaining an accurate diagnosis of anisakiosis can prevent unnecessary surgery. However, in rare cases, extra-gastrointestinal migration of larvae can cause severe damages with practically unknown risks, posing a diagnostic and therapeutic dilemma. In such clinical case scenario, surgical exploration can decisively contribute to a definitive diagnosis and early identification of intraabdominal complications necessitating surgical intervention.
Carbon Instrumentation in Patients with Metastatic Spinal Cord Compression
Authors: Schmidt Morgen Søren , Alfthan Madsen Emma Benedikte , Skive Weiland Anders , Dahl Benny , Gehrchen Martin
Published: January 2024

Keywords: Spine surgery 1; Metastatic spinal cord compression 2; Spinal metastasis 3; Cancer treatment.
Damage Evaluation in Plain-Woven CFRP Plate with Circular Hole under Cyclic Tensile Loading Using Electrical Impedance Tomography
Authors: Heinzlmeier Lukas , Wagner Jonas , Kimpfbeck Daniel , Sieberer Stefan , Kralovec Christoph , Schagerl Martin
Published: January 2024

Understanding and predicting damage progression within thin plain-woven CFRP components is an essential issue for scheduling maintenance intervals and structural inspections, and typically require extensive test series. However, uncertainties always remain and result in conservative design and unnecessary downtimes due to the repeated inspections of a healthy structure. SHM can be used to reduce these uncertainties, as it allows to evaluate the condition of a mechanical structure during operation. Numerous SHM methods are developed , that achieve different levels of damage identification but are often investigated at small coupons with non-realistic structural damages and loading conditions on both, structure and sensor. The present research investigates the electrical impedance tomography (EIT) featuring an elastoresistive thin-film sensor to evaluate damage that propagates from a circular hole in a large plate under cyclic tensile-tensile multi-block loading. Applied fatigue loads were increased multiple times up to a total number of two million cycles. During the loading damage initiated at the hole and continuously propagated into the plate. Repeated EIT evaluations of the applied sensor and validating evaluations by means of digital image correlation clearly revealed the robustness of the hardware and the potential of the SHM method for damage evaluation of plain-woven CFRP components.
Optimizing Cell Inoculation in a Microfluidic System in Order to Mimic the Hemato-Encephalic Barrier and Tumor Dynamic Cell Interaction
Authors: Santillán-Cortez Daniel , Castell-Rodríguez Andrés Eliú , González-Arenas Aliesha , Suarez-Cuenca Juan Antonio , Hautefeuille Mathieu Christian Anne , Pérez-Koldenkova Vadim , Añorve-Bailón Denisse , García Silvia , Toledo Lozano Christian Gabriel , Escamilla-Tilch Mónica , Mondragón-Terán Paul
Published: January 2024

Microfluidic systems offer precise control over physiological, biochemical, and mechanical stimuli in cell culture, allowing in vitro emulation of tissue or tumor microenvironments. This study aims to advance our understanding of tumor biology and contribute to personalized therapy development. Overcoming challenges in cell culture, including cell density and microfluidic device properties, is essential for this purpose. We designed a microfluidic system to facilitate the interaction of diverse cell lineages, incorporating human brain microvascular endothelial cells (HBEC5i), glioblastoma multiforme cells (U87MG), and astrocytes (ScienceCells 1800). Post-fabrication, we assessed the system's functionality and systematically evaluated cell inoculation conditions. Photographic acquisitions comprehensively captured cell culture and their interactions. The device successfully enabled assessment of cellular proliferation, invasion, and migration, supporting the growth of monolayers and tumor organoids. Importantly, each channel demonstrated independence in study processes while allowing cellular intercommunication, both physically and biochemically. In conclusion, the functional microfluidic device facilitated the study of cell migration, tumor invasion, and organoid growth, faithfully replicating biological features observed in a tumor microenvironment. This research contributes to advancing our understanding of tumor biology for the development of personalized therapies.
Metallic Ratios are Uniquely Defined by an Acute Angle of a Right Triangle
Authors: Łukaszyk Szymon
Published: January 2024

We show that metallic ratios for real k are uniquely defined by an acute angle of a right triangle, where for k ≠ {0, ±2} this angle is a logarithm of a normalized complex number, and for rational k this number is defined by a Pythagorean triple.
Simulated Dopamine Modulation of a Neurorobotic Model of the Basal Ganglia
Authors: Prescott Tony J. , Montes Gonzalez Fernando , Gurney Kevin , Humphries Mark D. , Redgrave Peter
Published: January 2024

The vertebrate basal ganglia are thought to play an important role in action selection—the resolution of conflicts between alternative motor programs. The effective operation of basal ganglia circuitry is also known to rely on appropriate levels of tonic dopamine transmission. We show that when the tonic level of simulated dopamine in a robotic model of the basal ganglia is significantly reduced or increased, relative to an effective operating baseline, a variety of behavioral outcomes are observed that provide interesting comparisons with the results of human and animal studies. The main findings were that progressive reductions in the levels of simulated dopamine caused a slowing of the robot’s movements and eventually an inability to initiate movement. These states were partially relieved at increased salience levels (stronger sensory/motivational input). Conversely, increased levels of simulated dopamine could cause distortion of the robot’s motor acts through partially-expressed motor activity relating to losing actions; this could also lead to increased frequency of switching between behaviors. Levels of simulated dopamine that were either significantly lower or higher than baseline could cause changes to the timing of behavior switching that could cause a loss of behavioral integration, sometimes leaving the robot in a ‘behavioral trap’. That some analogous traits are observed in animals and humans affected by dopamine dysregulation suggests that embodied (robotic) models could prove useful in understanding the role of dopamine neurotransmission in basal ganglia function and dysfunction. That the effects of simulated dopamine on robot action selection were partially, but not fully, predictable from the selection properties of the non-embodied basal ganglia model, also points to the added value of using robotic models to explore the relationship between brain activity and behavior.
Particle Physics and Cosmology Intertwined
Authors: Nath Pran
Published: January 2024

While the standard model accurately describes data at the electroweak scale without inclusion of gravity, beyond the standard model physics is increasingly intertwined with gravitational phenomena and cosmology. Thus gravity mediated breaking of supersymmetry in supergravity models lead to sparticles masses, which are gravitational in origin, observable at TeV scales and testable at the LHC, and supergravity also provides candidate for dark matter, a possible framework for inflationary models and for models of dark energy. Further, extended supergravity models, and string and D-brane models contain hidden sectors some of which may be feebly coupled to the visible sector resulting in heat exchange between the visible and hidden sectors. Because of the couplings between the sectors both particle physics and cosmology are effected. The above implies that particle physics and cosmology are intrinsically intertwined in the resolution of essentially all of the cosmological phenomena such as dark matter and dark energy and in the resolution of cosmological puzzles such as Hubble tension and EDGES anomaly. Here we give a brief overview of the intertwining and implications for the discovery of sparticles, and the resolution of the cosmological anomalies and identification of dark matter and dark energy as major challenges for the coming decades.