bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiple Sclerosis: Molecular Biology, Pathophysiology and Biomarkers
Authors: Singh Sanjay , Tripathy Sukanya , Prakash Anand
Published: August 2022

In the brain, multiple sclerosis is a chronic disease caused by immunemediated neurodegeneration. About 2.5 million people around the world suffer from
multiple sclerosis (MS), and women are more prone to it. Neither clinical nor imaging
biomarkers are used to diagnose or characterize the disease. Molecular biomarkers have
been developed from immunology and neurobiology because they are well matched
with causal path mechanisms and other disease characteristics, thus, limiting the
number of molecular biomarkers used in clinical practice. Currently, the chapter
discusses the attribute of flawless MS biomarkers and the challenges associated with
developing newer biomarkers. The study also discusses the discovery of biomarkers
from the blood and cerebrospinal fluid (CSF) that are useful for diagnosing MS,
predicting its prognosis, and evaluating its therapeutic response and side effects.
Emerging Therapeutic Approaches for Neurodegenerative Diseases
Authors: Ugale Rajesh R. , Sarode Lopmudra
Published: August 2022

The most common neurodegenerative diseases (ND) include Alzheimer’s
disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), as well as
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Protein
misfolding and aggregation are the key hallmarks of these neurodegenerative diseases,
which may lead to cell death, axonal regeneration failure, demyelination, and overall
neuronal structural and functional deficits. Usually, ND is diagnosed at a very
advanced stage and conventional therapies are directed at treating neurological
symptoms but have no effect on disease progression. In general, several pathological
processes contributes to misfolding proteins/protein aggregates and their postconsequences, including impairment of autophagy, microtubule destabilization,
neuroinflammation, proteostasis, mitochondrial dysfunction, oxidative stress,
endoplasmic reticulum stress, calcium homeostasis, and neurogenesis impairment.
Indeed, several signaling pathways critically linked with these pathological processes
are now becoming attractive targets and investigated for their beneficial effects by
restricting the progression of ND. In particular, certain signaling mechanisms and
proteins found to show an integral involvement in the pathogenesis of ND and had
shown promising results in preclinical and/or clinical contexts. For ex; novel autophagy
stimulators, drugs acting on mTOR, NRF2, TLR, purinergic signaling; drugs acting on
neuroinflammatory signaling pathways, Heat Shock Proteins (HSP), sestrins, sirtuins,
some PDE-inhibitors, miRNA’s have gained a lot of attention in the therapy of ND and
are included in the following discussion.
Neuropharmacology in Alzheimer and Huntington Disease
Authors: Gupta Bandna , Rohatgi Kopal
Published: August 2022

The Alzheimer’s disease and Huntington’s disease are the two important
neurodegenerative disorders currently under research for various therapeutic
approaches ranging from newer biochemical molecules, plant extracts and food
supplements to highly advanced biotechnological and genetic therapies.

Alzheimer’s disease (AD), one of the leading causes of disability in the elderly
population is exponentially rising worldwide. The acetylcholinesterase inhibitors and
memantine, the mainstay of treatment only slow down the disease progression and
provide symptomatic improvement. The cholinesterase inhibitors, rivastigmine and
donepezil apart from improving cognition also delay hospitalization and reduce
behavioural and psychological symptoms of dementia. Other cholinesterase inhibitors
and cholinomimetic targets like muscarinic and nicotinic receptor agonists are in
development. Extensive research in this area in the past few decades has given insight
into the cellular and molecular pathogenesis of the disease. This has led to the
development of certain novel strategies to modify the disease progression and
prognosis. This includes amyloid and tau-based therapeutics, various immunotherapies,
vaccines and food and plant supplements. Other new promising agents under research
are anti-inflammatory drugs, neurotrophic factors and antioxidants. Huntington’s
disease is a rare inherited neurodegenerative disorder producing motor, cognitive and
psychiatric symptoms. A greater understanding of the pathology in the recent past has
led to research into the development of newer therapeutic agents mainly DNA and
RNA based therapies and technologies using gene editing tools.

Several of these putative drugs are in preclinical studies and many of them have failed
to show positive results. In this section, we are going to discuss the approved therapies
for AD and HD currently in use, the status and evidence regarding drugs in various
stages of clinical trial and mention advanced biotechnological and gene therapies under
investigation.
Analysis of differences in effectiveness between salt water bath therapy and ginger water bath therapy on pain scale and its relationship with age, gender, and education level in gout sufferers in the working area of the Mpunda Public Health Center of Bima City
Authors: Sayful Sayful , Julhana Julhana , Swandayani Rosalina Edy
Published: August 2022

Background: Gouty arthritis is an inflammatory disease that affects the connective tissue of the joints, is progressive, symmetrical, and systemic, and tends to turn chronic. It has typical symptoms experienced by sufferers, such as pain in one or more joints. These symptoms can interfere with comfort in activities. Method: This study used a Quasi-Experimental design with a Two Group Pretest-Posttest approach. Sampling was done using the Quota sampling technique, resulting in 40 respondents chosen. Data analysis in this study, to answer research questions and hypotheses, was bivariate analysis using 4 (four) types of statistical tests, namely 1) Wilcoxon test, 2) Mann-Witney test, 3) Test Gamma correlation, and 4) Chi-square test with a significant level ? of 0.05. Results: The results showed that the Mean Rank of the warm salt water bath group was lower, namely 18.55, while that of the warm ginger water bath group was 22.45. The statistical test results showed that the p-value was 0.145> 0.05, meaning that statistically, there was no difference in effectiveness between the two therapies on the pain scale of respondents because the value did not reach 5.
Characteristics of cured egg yolk cookies subtituted with skim milk powder during storage
Authors: Nurliyani Nurliyani , Jamhari Jamhari , Widodo Widodo , Agustin Citravia
Published: August 2022

Cured egg yolk cookies is one of the processed egg products containing egg yolk which has been curing with salt and sugar. The purpose of this study was to evaluation of physical, chemical, microbiological and sensory quality of cured egg yolk cookies with various levels of skim milk powder substitution during storage at room temperature. This study consisted of the treatment of cured egg yolk substitution with skim milk powder (0; 20; 40%) and storage treatment (0; 3; 6; 9 weeks). Each treatment was replicated three times. The data of cookie quality were statistically analyzed using ANOVA. The results showed that cured egg yolk cookies with various skim milk powder substitution have similar physical and chemical characteristics, but substituted cookies had a lower fat content (p<0.05). There were no changes in the moisture content of cookies during 9 weeks of storage. Skim milk powder substitution could increase the peroxide number, but there was no change in the peroxide number during 3 to 9 weeks of storage. The texture of cured egg yolk cookies with 40% skim milk substitution was harder (p<0.05) than the 20% skim milk substitution, whereas there was no change in the texture value of cured egg yolk cookies before and after being stored for 9 weeks. There was no significant deferences in the sensory quality of cookies between unsubstituted and 40% skim milk powder substitution. In conclusion, skim milk powder substitution did not change the physical, chemical, and sensory characteristics, but could reduce fat content, increase the peroxide number and the hardness of cookies. During 9 weeks of storage, cured egg yolk cookies are still acceptable microbiologically.
Why Drag? Observations on drag performance in times of drag popularity
Authors: Baetens Simon
Published: August 2022

Simon Baetens is een student Drama aan het KASK, waar hij momenteel zijn master afwerkt. In deze artistieke bijdrage, werpt hij een blik op theoretische hoek op een andere artistieke praktijk van hem als dragperformer. Aan de hand van een visuele en tekstuele collage, maakt hij een kritische reflectie over drag in connectie tot zijn eigen werk binnen het Gentse dragperformance collectief House of Lux. 
Ultrasonography Vs. Per Rectal Examination for Uterine Involution in Methyl Ergometrine and Other Supplements Treated Crossbred Cows
Authors: Madhwal Deepa . , Sharma Mridula . , Patra Manas .
Published: August 2022

Normally calved 36 post-partum HF crossbred cows from first to seventh parity were selected from University Farm and divided randomly into 6 equal groups. In all treatment groups (T1 to T5), injections of methyl ergometrine maleate (Ergovet, 2 mg, i/m, OD) at 1/2 hr, 2nd and 3rd day post-partum were given. Additionally, in T2, calcium (Mifex, 50 mg/ml, @ 300 ml, i/v) and phosphorus (Tonophosphan, 0.2 gm/ml, @ 10 ml, i/m, OD) were injected on second day of calving; in T3, Vit. ADE (Intavita, @ 10 ml, i/m, OD) on the second day of calving; in T4, Ceftiofur sodium (Xyrofur, 1 gm, i/m, OD) for three days from the second day of calving, and in T5, Calcium, phosphorus, Vit. A D E and Ceftiofur sodium were given with same dosage. The sixth group (T6, control) was left untreated. Cervical and uterine (previously gravid; PG and non-gravid; NG horns) diameters and uterine involution were examined by USG and per rectal palpation, at 5 days interval from day 12 to day 40 post-partum, to observe the effect of methyl ergometrine with and without above combinations on uterine involution. The reduction was observed earlier in T1, T2, and T5, by per rectal palpation compared to USG examination, while in T3, T4 and C, both methods were at the same time. PG and NG horn diameters were reduced significantly (p less than 0.05) earlier in all treatment groups (T1 to T5) as compared to control. Uterine involution was found to be completed by per rectal palpation on day 32 post-partum in all treatment groups and on day 37 in control, whereas by USG examination, it was on day 32 in T1 and T5 and on day 37 in all other groups. Methyl ergometrine along with Ca, P, Vit. ADE and ceftiofur, enhanced uterine involution in CB cows. Further, the uterine and cervical assessment by per-rectal palpation revealed fast involution as compared to USG.
Influence of Different Synchronization Protocols on Fertility Response in Surti Does
Authors: Sharma Hitendra C , Khasatiya Chandubhai T , Tyagi Kuldeep K , Modi Lalit C.
Published: August 2022

This study was carried out to assess the influence of different estrus synchronization Protocols on fertility response in Surti does based on litter size, fecundity and twining rate. Thirty does were selected and divided into five equal groups (n=6 in each). Does of G1 group were treated with intra-vaginal progestagen sponges (IVPS) for 11 days. Does of G2 group received the same IVPS sponge for 11 days and exposure of sexually active apronized buck during the treatment period. Does of G3 group were treated as per G1 group along with i/m injection of PGF2andalpha; analog (125 µg, Cloprostenol) at the time of sponge removal. Does of G4 group were subjected to the buck effect and exposed to a sexually active patronized buck for 11 days, and does of G5 group was kept as a control without any treatment for 11 days. It was found that, none of the synchronization Protocols had significant effect on litter size, fecundity, and incidence of multiple kid birth and sex ratio in Surti does.
Effect of Feeding Concentrate Mixture Containing Varying Levels of Cashew Nut Kernel Meal on Nutrient Utilization in Ram Lambs
Authors: Balaga Sravani , Konka Raja Kishore , Dhulipalla Srinivas Kumar , Matha Kalyana Chakravarthi
Published: August 2022

The present study was conducted to assess the effect of feeding concentrate mixture containing varying levels of cashew nut kernel meal (CNKM) on nutrient utilization in ram lambs. Eighteen ram lambs were randomly divided into three equal groups of six each and allotted to three dietary treatments (T1 to T3) comprising of green fodder viz., Super Napier and concentrate mixture (20% CP) containing CNKM at 0, 10 and 20%, respectively. The average DMI of ram lambs was comparable among treatments. Significantly higher (P less than 0.05) digestibility (%) of DM, OM, CP, EE, CF, NFE, NDF, ADF and cellulose was observed in ram lambs of group T3 compared to control, while the difference in hemicellulose was non-significant. The TDN content expressed as % in diet consumed was higher (p less than 0.05) in T3 compared to control, while the difference in DCP (%) in the diet consumed was not significant. The estimated DE and ME intakes (Mcal/d) increased (p less than 0.05) with increased level of CNKM in the concentrate mixture, while there was no significant difference in the intakes of DM, DCP, TDN and ME per kgW0.75.
Impact of Various Ovulation Synchronization Protocols on Serum Triglycerides and Cholesterol Profile in Repeat Breeder Cows during Different Breeding Seasons
Authors: Manokaran Sakthivelu . , Napolean Rayappan E. , Selvaraju Mani . , Balasubramaniam Gurusamipalyam A. , Palanisamy Mahakrishnan . , Geetha Thangavel .
Published: August 2022

The present study evaluated whether various ovulation synchronization protocols modulate cholesterol and triglycerides profile and enhance fertility in repeat breeding crossbred cows under field conditions. The study was conducted in 100 repeat breeder cows which were divided into five experimental groups, viz., Group I, II, III, IV (Treatment groups) and Group V (Control group) during the high breeding season (HBS: i.e., from October to March) and low breeding season (LBS: i.e., from April to September). Fifty cows were used during HBS and 50 cows during LBS. The Ovsynch, Presynch+Ovsynch, Ovsynch+Post-AI GnRH, and Ovsynch+Vitamin A protocols were followed to treat the Group I, II, III, and IV cows, respectively, and artificial insemination was performed during induced estrus. The group V cows were inseminated during observed estrus. There was an increasing trend in cholesterol concentration from selection to 7 days post-AI in all the groups in both HBS and LBS. Further, the cholesterol concentration was higher during HBS than LBS. The pregnant cows had significantly (p less than 0.05) higher mean (±SE) serum cholesterol levels than non-pregnant cows in both seasons. There was no much variation in serum triglycerides concentration between pregnant and non-pregnant cows. The study showed that the cholesterol concentration was affected by the season of the year, whereas the serum triglyceride concentration was not affected. The synchronization protocols used to affect the serum cholesterol concentration rather than serum triglycerides in repeat breeder cows during different seasons.
Effect of Exogenous Melatonin and Different Photoperiods on Differential Leucocyte Count in Chhotanagpuri Ewe
Authors: Choudhary Pankaj K. , Ishwar Ajay K. , Kumar Pramod . , Maurya Pankaj K. , Kumar Mukesh . , Kumar Rajesh . , Niyogi Debasish .
Published: August 2022

Forty-two healthy, non-pregnant, non-lactating Chhotanagpuri ewe, having body weight ranging from 14.11 ± 0.09 to 15.38 ± 0.06 kg, were selected and isolated from rams 2 months before melatonin administration. The selected animals were allocated randomly into seven groups each of 6 animals, viz., Group-I Normal control, Group-II Long day (LD) control), Group-III (LD + melatonin administration 3 mg/day orally, Group-IV
Isolation, Characterization, Antibiogram and Molecular Detection of Antibiotic Resistance Genes from Bacteria Isolated from Otitis Externa in Dogs
Authors: Doshi Dhruvi M. , Bhanderi Bharat B. , Mathakiya Rafiyuddin A. , Nimavat Vipul R. , Jhala Mayurdwaj K.
Published: August 2022

Otitis externa is one of the most common diseases of the canines, defined as an acute or chronic inflammation of the external ear canal. In the present study, 124 samples were collected, out of which 94 samples were from 75 dogs suffering from otitis externa and 30 from 15 healthy dogs from the regions of Anand and Vadodara districts of Gujarat. Total 129 bacteria comprised of Staphylococcus spp. (58.40%), Pseudomonas spp. (10.62%), Proteus spp. (10.62%), Streptococcus spp. (7.08%), Corynebacterium spp. (6.19%), E. coli (4.42%), Klebsiella spp. (1.77%) and Enterobacter spp. (0.88%) were isolated from otitic and healthy ears of dogs based upon colonial, microscopic, and biochemical characteristics. The bacterial isolates showed least resistance towards tobramycin (1.51%) followed by enrofloxacin (5.52%), ofloxacin (11.98%), amikacin (15.20), gentamicin (17.07), and amoxycillin clavulanic acid (17.53%), while they showed the highest resistance towards ampicillin (63.90%). The multidrug resistance was detected in 29.46% (34/129) of the total bacterial isolates. Beta-lactam resistance genes were detected in E. coli, Klebsiella spp., Enterobacter spp. and Pseudomonas spp.; quinolone resistance genes were detected in E. coli, and aminoglycoside resistance genes were detected in E. coli, Proteus spp. and Staphylococcus spp.
Effect of Water Restriction and Rehydration on Haemato-Biochemical, Enzymatic and Hormonal Activity of Hoggets during Summer Season
Authors: Patel Nitin R. , Modi Rakesh J. , Islam Manzarul . , Wadhwani Kishan N.
Published: August 2022

Present experiment was conducted with the objective to study the effect of water restriction and rehydration on haemato-biochemical, hormonal and enzymatic activity of indigenous sheep under intensive production system. Eighteen farm born unshorn hoggets (25-30 kg) of Patanwadi and Marwari breeds were randomly distributed in to three treatment groups on the basis of body weight comprising of six in each group viz., T1 Control (ad libitum water), T2 (20% water restriction) and T3 (40% water restriction). The experiment was conducted in summer season for 30 days i.e. 28 days of water restriction and 2 days of rehydration phase. The feed, in accordance with physiological and production needs of the animals, was offered twice a day (09:00 and 18:00 hrs). Water intake was recorded thrice a day (09:00, 14:00 and 19:00 hrs) and blood samplings was done on day 0, day 28 and after 48 hrs of rehydration. The values of haemoglobin, were significantly decreased, while, serum urea, uric acid, alkaline phosphatase, creatinine phosphokinase, cortisol, triiodothyronine and aldosterone were significantly (p less than 0.05) increased in water restricted groups of animals on 28th day, with significant improvement in values on 48 hrs of rehydration in most of the traits. However, the decrease in glucose was non-significant between 0 and 28 days and no change was noted in thyroxin levels due to water restriction or rehydration. It indicated that water restriction resulted significant changes in blood variables of hoggets. Blood variables recovered significantly after 48 hr of rehydration, but the serum cortisol, urea, AKP, CPK and T3 values till did not attain normalcy, thereby demonstrating that the animals did not recover completely from dehydration stress.
Composición nutricional y digestibilidad de semilla, torta y cáscara de dos especies de sacha inchi (Plukenetia volubilis y Plukenetia huayllabambana)
Authors: Taipe Cuadra Raquel , Fernández Curi Melisa , Villanueva Espinoza María Elena , Gómez Bravo Carlos
Published: August 2022

En Perú, sacha inchi (Plukenetia volubilis) tiene un gran potencial de producción y de industrialización; sin embargo, aún no se conoce el valor real de la semilla y sus subproductos para uso en alimentación animal. El objetivo del estudio fue determinar la composición nutricional y contenido de antinutrientes (saponinas y taninos) de las tortas de Plukenetia volubilis y Plukenetia huayllabambana, así como la composición proximal de las semillas y de las cáscaras. Para ello, se determinó el contenido de humedad, proteína cruda, fibra cruda, extracto etéreo, extracto libre de nitrógeno, cenizas, fibra detergente neutro (FDN) y fibra detergente ácido (FDA), así como el contenido de taninos, saponinas, perfil de ácidos grasos y digestibilidad in vitro de la materia orgánica (DIVMO) de torta de sacha inchi. No se encontraron diferencias estadísticas (p > 0,05) para los componentes nutricionales evaluados en semilla, cáscara y torta de ambas especies de sacha inchi. Sin embargo, las semillas de P. huayllabambana presentaron mayor cantidad de extracto etéreo, pero menor contenido de proteínas que P. volubilis. Asimismo, en P. volubilis el contenido de proteína de la torta fue menor que P. huayllabambana. La cáscara de P. volubilis presenta un menor contenido de fibra que P. huayllabambana. Los DIVMO de torta P. volubilis y P. huayllabambana no mostró diferencias estadísticas (p > 0,05). La concentración de ácidos grasos poliinsaturados fue superior en P. volubilis (p < 0,05). La torta de sacha inchi de ambas especies presenta potencial para ser utilizadas en alimentación animal por su alto valor nutricional y ausencia de antinutrientes.
Development of a Mobile App for Self-Care Against COVID-19 Using the Analysis, Design, Development, Implementation, and Evaluation (ADDIE) Model: Methodological Study
Authors: Saeidnia Hamid Reza , Kozak Marcin , Ausloos Marcel , Herteliu Claudiu , Mohammadzadeh Zahra , Ghorbi Ali , Karajizadeh Mehrdad , Hassanzadeh Mohammad
Published: August 2022

Background

Mobile apps have been shown to play an important role in the management, care, and prevention of infectious diseases. Thus, skills for self-care—one of the most effective ways to prevent illness—can be improved through mobile health apps.

Objective

This study aimed to design, develop, and evaluate an educational mobile-based self-care app in order to help the self-prevention of COVID-19 in underdeveloped countries. We intended the app to be easy to use, quick, and inexpensive.

Methods

In 2020 and 2021, we conducted a methodological study. Using the ADDIE (analysis, design, development, implementation, and evaluation) educational model, we developed a self-care management mobile app. According to the ADDIE model, an effective training and performance support tool is built through the 5 phases that comprise its name. There were 27 participants who conducted 2 evaluations of the mobile app’s usability and impact using the mobile health app usability and self-care inventory scales. The study design included pre- and posttesting.

Results

An Android app called MyShield was developed. The results of pre- and posttests showed that on a scale from 0 to 5, MyShield scored a performance average of 4.17 in the physical health dimension and an average of 3.88 in the mental well-being dimension, thereby showing positive effects on self-care skills. MyShield scored highly on the “interface and satisfaction,” “ease of use,” and “usefulness” components.

Conclusions

MyShield facilitates learning self-care skills at home, even during quarantine, increasing acquisition of information. Given its low development cost and the ADDIE educational design on which it is based, the app can be helpful in underdeveloped countries. Thus, low-income countries—often lacking other tools—can use the app as an effective tool for fighting COVID-19, if it becomes a standard mobile app recommended by the government.
Skin Cancer and Sun Protective Knowledge, Behaviors, and Beliefs among Latinos with Tattoos (Preprint)
Authors: Li Jeffrey Niu , Gonzalez Cristian D , Vasquez Rebecca , Savory Stephanie , Dallavalle Robert P , Walkosz Barbara J
Published: August 2022

BACKGROUND

Latinos with tattoos are a growing demographic but their attitudes about skin cancer are generally unknown. With increased rates of skin cancer in the Latino community, this subpopulation presents a unique opportunity for a targeted public health campaign.

OBJECTIVE

To explore the demographics, skin cancer knowledge, sun safety behaviors, social media use, and willingness to learn about sun protection of Latinos with tattoos.

METHODS

Interviews with 25 participants were conducted. Data was coded by a third party. Thematic analysis identified recurrent sub-themes from the transcript.

RESULTS

No participants had a history of skin cancer; only 28% knew someone with skin cancer. Fifteen (60%) endorsed never, rarely, or only seasonal sunscreen use and 20% utilized sunscreen on their tattoos only. Nearly all (92%) had two or more tattoos. All used social media and a majority followed tattoo artists.

CONCLUSIONS

Latinos with tattoos are a growing demographic that demonstrate suboptimal sun protective behaviors. Education efforts enlisting tattoo artists and social media could optimize sun protective behaviors in this group.
ASIAN GIANTS: Institutional Outcomes
Authors: Lane Jan-Erik
Published: August 2022

Swedish sociologist and Nobel laureate Gunnar Myrdal focused on Asian poverty in his major work An Asian Drama (Myrdal, 1969). Now after fifty years of rapid economic development it is time to inquire into institutional performance and we-ordered societies. The measuring rod -rule of law- has nò basis in mainstream Asisn philosophies: neither Hinduism or Buddhism nor Confucianism or Shintoism.
EFFECTS OF AQUEOUS EXTRACT OF PURIFIED CURCUMA LONGA ON ANXIETY LEVELS IN SWISS ALBINO MICE
Authors: SHARMA ASHISH
Published: August 2022

Objectives: This study was performed to see the effects of aqueous extract of purified Curcuma longa (CL) on anxiety levels of Swiss albino mice using open-field test.
Methods: CL at 50 mg/kg body weight (b.w) (CL50), CL at 100 mg/kg b.w. (CL100), and CL at 200 mg/kg b.w. (CL200) with negative and positive controls were used. The experimental results were represented as mean±standard deviation, p<0.05 was considered. Statistical differences between the test drug and control groups as well as within the test drug groups were calculated using Mann–Whitney U-test.
Results: The number of squares crossed in 5 min was least in distilled water (DW) as compared to all other groups (CL50, CL100, and CL200 [p=0.002], diazepam [p=0.002]).Time spent in the central square was lesser in the DW group than CL50 (p=0.045), CL200 (p=0.005), and DP (p=0.004). More time was spent by DP in the central square than CL50 (p=0.045) and CL100 (p=0.037) groups. The number of rearing was lesser in DW group as compared to CL50 (p=0.030), CL100 (p=0.006), and CL 200 (p=0.006) as well as DP. The number of rearing was less in CL50 than CL200 (p=0.045) group.
Conclusion: This study showed that CL possesses anxiolytic effect.
HLA-DRB1 ALLELE DISTRIBUTION IN HEALTHY INDIVIDUALS CLASSIFIED BASED ON MIZAJ (TEMPERAMENT) OF UNANI SYSTEM OF MEDICINE
Authors: MULLA GHAZALA , SHAH TEJAS , JOSHI KALPANA , AHMED JALIS , QURESHI FARHAN
Published: August 2022

Objective: Assessment of Mizaj of 500 healthy individuals between the age group of 25and 40 years of the age group of either gender was carried out by validated Unani questionnaire and Sheldon’s somatotype. The present study was designed to investigate if the frequency of HLA-DRB1 alleles in the healthy adult population has any association with four Mizaj.
Methods: Mizaj of the healthy individuals (n=500) was assessed by a validated Unani questionnaire based on 10 parameters related to phenotypic and psychological entities known as Ajnas-e-Ashra. Mizaj of the same subjects was further assessed by Sheldon’s somatoplot. Polymerase chain reaction-sequence-specific typing method was used for human leukocyte antigen (HLA) genotyping of 180 healthy volunteers.
Conclusion: An expected correlation between HLA-DRB1 alleles and Mizaj types is observed. Five single-nucleotide polymorphisms (p<0.05) were significantly associated with different Mizaj. The study suggests that the Mizaj classification of the Unani system of medicine has a genetic basis. This study would be one step toward a personalized approach as per the Mizaj of an individual to disease proneness, lifestyle modification, and medicine.
STUDY OF CLINICAL AND ECHOCARDIOGRAPHIC PROFILE IN PATIENTS OF DILATED CARDIOMYOPATHY
Authors: BEHERA BIJAYA KUMAR , NAIK M. RADHA KRISHNA , JALI SIBA NARAYAN , TRIPATHY SUSMITA , BEHERA NISARG
Published: August 2022

Objective: Dilated cardiomyopathy (DCM) is the third most common cause of heart failure (HF) and is the most common cardiomyopathy. The present study was undertaken with the aim to study the different clinical presentations of dilated cardiomyopathy, to correlate echocardiography findings with different clinical presentations and to find out the variables which determine the poor outcomes.

 

Methods: This prospective observational study was conducted in the Department of General Medicine of MKCG Medical College and Hospital, Berhampur, Odisha, India from November 2019 to November 2021. Fifty cases of dilated cardiomyopathy (28 males & 22 females), diagnosed on clinical and echocardiography criteria in the Department of General Medicine and Cardiology were selected for the study.

 

Results: Out of 50 cases, there were 28(56%) males and 22(44%) females giving male to female ratio 1.27:1. Forty (80%) were idiopathic. Dyspnea was most common presenting clinical feature in 43(86%) cases. In echo study, maximum number of cases (n=21, 42%) were having ejection fraction (EF) in the range of 36-40% and maximum number of cases (n=26, 52%) had severe fractional shortening (FS).

 

Conclusion: DCM is one of the commonest causes of heart failure and is most common type of cardiomyopathy found in middle aged and elderly male population. Biventricular failure followed by left ventricular failure was the most frequent clinical presentation. Early identification and treatment are very essential to improve cardiac function and alleviate patient symptomology.
COVID-19 VACCINE HESITANCY FOR CHILDREN IN PARENTS: A CROSS-SECTIONAL SURVEY AMONG HEALTH-CARE PROFESSIONALS IN INDIA
Authors: HIMANSHI  , KADAM KRANTI S , U UTTARWAR PARUL
Published: August 2022

Objectives: There is evidence of morbidity and mortality in children due to COVID-19 infection. “Vaccine Hesitant Parents (VHPs)” may act as barriers to vaccination of children and their knowledge, attitude, beliefs, and perceptions come into play. Health-care providers are cited as the most important source for vaccine information by VHPs, and provider recommendation for vaccination is crucial for improving vaccine uptake. Hence, we aim to study among Indian health-care professionals having children <18 years of age, the prevalence of parental hesitancy for pediatric COVID-19 vaccine and to assess their knowledge, attitude, beliefs, and perceptions about pediatric COVID-19 vaccine.
Methods: An observational, cross-sectional study was conducted across India through a web-based questionnaire amongst health-care professionals having children less than 18 years of age by Snowball sampling technique. Descriptive statistics were used to study the demographic profile, the prevalence of vaccine hesitancy, and individual factors. Correlations between the datasets were obtained using regression analysis and significance level using the Chi-square test.
Results: The prevalence of COVID-19 vaccine hesitancy for children in Indian health-care professionals is 3.3%. The most important source of information was the internet and social media. The majority of the participants knew about the vaccine and its side effects (p=0.00) and believed in the usefulness of the vaccine in preventing infection (p=0.008) and in reducing severity (p=0.009). All these factors lead to better vaccine acceptance.
Conclusion: These data show that vaccine acceptance has improved over time and thus HCWs can aid in reducing vaccine hesitancy.
A CROSS-SECTIONAL STUDY OF ATTITUDE AMONG MEDICAL STUDENTS ABOUT ONLINE LEARNING DURING COVID-19 PANDEMIC IN SOUTHERN INDIA
Authors: RAYAM SRIHARSHA , MUSADDIQ SHABNUM , MEEGADA PURNA PRASAD
Published: August 2022

Objectives: The study aimed to assess the attitude of the medical students toward online classes during COVID-19 pandemic in Southern India.
Methods: This study was an online cross-sectional descriptive study. First- and 2nd-year medical students were asked to fill out an online questionnaire using Google form. The participants were asked to answer the questions on a Likert scale, from 1 to 5. The questionnaire consists of details about the type of gadgets, type of internet connection used for E-learning classes, overall Students’ attitude and satisfaction with online education, and the challenges associated with online teaching.
Results: A total of 279 medical students participated, among them 168 (60.2%) were females and 111 (39.8%) were males. About 43.36% of students used mobiles for purpose of E-learning. 59.14% of students expressed their interest to incorporate E-learning into the curriculum in the future. Regarding students’ attitudes and satisfaction with online education, 63.4% stated that easy to access online teaching and 50.15% stated that online teaching was effective, 48.35 stated that online teaching was engaging and visually attractive 45.9% and 38% stated that online teaching was the effective communication method. Major challenges associated with online teaching were lack of cocurricular activities that was 63.5% followed difficulty to concentrate during classes was 58.7%. For plans and criteria for evaluation, 58.06% preferred the objective method of examination.
Conclusion: The majority of students showed positive responses toward online teaching during COVID-19 pandemic but there are certain challenges like lack of cocurricular activities and difficulty concentrating during classes.
PROBLEM BASED MOBILE LEARNING IN BIOCHEMISTRY: AN INTERVENTIONAL STUDY IN PHASE I MBBS STUDENTS
Authors: JAMES REBECCA , THOMAS JOMY P , M CHITTADI SRUTHI
Published: August 2022

Objectives: The objectives of the study were (1) to compare the effectiveness of problem-based learning (PBL) in classroom and problem-based mobile learning (PBML) using a mobile application and (2) to study the perception of students to PBML and PBL in classroom.
Methods: After getting clearance from institutional ethics committee, an interventional study was conducted for a period of 2 months among 250 Phase IMBBS students of Government Medical College Kozhikode, Kerala. Students who gave consent for the study were divided into two groups, namely, R-1 and R-2, and analyzed for the effectiveness of PBML as a teaching learning method in comparison with PBL in classroom. Perception of students toward use of PBML and PBL as teaching learning method was collected using validated questionnaire.
Results: It was observed from the study that in all the sessions post-test mean scores were significantly higher than pre-test scores in both PBL and PBML. Before the intervention there was no significant difference in the pre-test mean scores in topics done by PBL and PBML. After intervention the only the post-test mean scores significantly improved. When the total post score scores of PBL and PBML compared, it was found that PBML mean score is significantly higher than PBL mean score. In the student’s perception analysis, it was found that both methods are effective in concept building, stimulating, helpful in passing exams, and development of problem-learning skills.
Conclusion: From the study finding, we can conclude that both PBL and PBML are effective modes of teaching applied biochemistry for Phase I MBBS students. PBML is more effective than PBL in teaching applied biochemistry in Phase I MBBS students. Perception analysis shows that interaction with the students and doubt clearance is more effectuated with PBL than PBML.
PREVALENCE OF SERUM SUBOPTIMAL VITAMIN D3 LEVELS AND ITS CORRELATION WITH TREATMENT OUTCOME, SOCIODEMOGRAPHIC PROFILE AMONG CANCER PATIENTS: A RETROSPECTIVE ANALYSIS
Authors: BERA ANJAN , DUTTA SHATARUPA , BANERJEE CHANDRIMA , BANERJEE SAPTARSHI
Published: August 2022

Objectives: In areas of etiology and prevention of cancer research, Vitamin D3 is currently one of the most promising agents. By virtue of anti-inflammatory, immunomodulatory, antiangiogenic, and proapoptotic effects, Vitamin D3 may inhibit carcinogenesis, cancer cell proliferation, and tumor progression. We wanted to study the prevalence of Vitamin D3 deficiency among cancer patients and whether there is any correlation between this Vitamin D3 level with response to the treatment of cancer and survival.
Methods: Between, January 2014 and December 2017, 199 patients, who completed treatment at our radiotherapy department, were included in this study. In a non-fasting state, a venous blood sample was obtained during the follow-up period, and the serum level of Vitamin D3 was determined by chemiluminescence immunoassay method.
Results: A higher prevalence of suboptimal D3 concentration was seen in patients with stable or progressive disease (PD) than in those patients cured, this was statistically significant. The complete response versus partial response and PD p-values are 0.0001 and 0.0008, respectively. Overall survival (OS) difference between D3 sufficiency and insufficiency is not statistically significant (p-0.4422). However, OS difference between D3 sufficiency and deficiency is statistically significant (p-0.0001). Similarly, the OS difference between D3 insufficiency and deficiency is statistically significant (p-0.0001).
Conclusions: Vitamin D3 level is significantly associated with response and there is also a positive correlation with OS. Statistically significant (p-0.0001) OS difference between D3 insufficiency and deficiency is present. Statistically significant higher prevalence of suboptimal D3 concentration was seen in patients with stable or PD than in those patients cured.
FUNCTIONAL AND RADIOLOGICAL OUTCOME OF TIBIAL PLATEAU FRACTURES MANAGED WITH INTERNAL FIXATION
Authors: NARAYANA M LAKSHMI , NAGARAJU K
Published: August 2022

Objectives: Tibial plateau fractures constitute a wide spectrum of severity from simple to complex fracture patterns. Treatment methods such as internal fixation and hybrid external fixation are commonly administered with specific limitations. The present study was designed to evaluate radiological and functional outcome of tibial plateau fractures managed with internal fixation. Methods: Thirty-six cases with tibial plateau fractures above 21 years were recruited. All the study cases were managed with open reduction and internal fixation. The post-operative follow-up was continued till 6 months with proper clinicoradiological evaluation to check range of motion, reduction loss, and fracture union. The functional outcome was assessed by Oxford Knee Society score and operative outcome was assessed by modified Rasmussen clinical and radiological criteria. Results: Functional outcome assessed by Oxford Knee Society score showed both excellent and good outcomes in 91.67% of cases cumulatively. Clinical outcome by modified Rasmussen assessment criteria reported excellent outcome in 33.33%, good in 44.44%, fair in 13.88%, and poor in 8.33%. Radiological outcome was excellent in 16.6%, good in 63.88%, fair in 11.11%, and poor in 8.33%. Conclusion: The post-operative functional, clinical, and radiological outcomes indicate that open or closed reduction and internal fixation had gained excellent results and are effective modalities in the management of tibial plateau fractures.
La fiesta del Niño Florero: una mirada socioambiental entre fronteras
Authors: Ballinas Aquino María Luisa
Published: August 2022

El objetivo de este artículo es mostrar las implicaciones sociales, religiosas y ambientales de la festividad del Niño Florero que se lleva a cabo en el municipio de Acala, Chiapas, mediante dinámicas en las que surgen los procesos de significación de los territorios que dan sentido a la festividad, a través de una investigación que integra la comprensión dialógica de las fronteras físicas y simbólicas presentes en la religiosidad vivida. El estudio se realizó mediante un proceso de triangulación considerando: la observación participante (2011-2014), las entrevistas a líderes (2011-2012) y material videográfico de la plataforma de YouTube en junio de 2021.
Multi-Class Fake News Detection Using Online Learning Approach
Authors: Mukherjee Rishita
Published: August 2022

Abstract: Data assiduousness on Internet, principally on social media platforms, happens to be an incontrovertibly introductory concern, still web-scale information acts as a roadblock to the capacity to classify, assess and address similar information, or contended "fake news", within reach in these stages. The easy access and dramatic heightening of the data open via online entertainment networks has made it tangled to make a differentiation among bogus and genuine data. The simple proliferation of data via sharing has strengthening to remarkable development of data distortion. A ton of exploration is as of now centered around recognizing it. The reliability factor diffusion of fake information with real one is ubiquitous. Along these lines, it has turned into an exploration challenge to consequently guarantee the data by its source, content and distributer for arranging it as misleading or valid. Machine learning plays had a basic influence in sorting of the data despite the fact that for certain regions. The procedure proposed by this paper is to make a model that will identify assuming an article is genuine or counterfeit in light of its words, expressions, sources and titles, by applying managed AI calculations on an annotated (labeled) dataset, that are manually classified and guaranteed. The imperatives of such methodologies and impromptu creation via it are likewise evaluated and inspected to execute profound learning.
A Review on Improvement of Road Accident Black Spots Using Corridor Approach
Authors: Shrivastava Kalpesh , Duggal Ajay K. , Asija Dr. Navdeep
Published: August 2022

Abstract: This paper talks about the Improvement method of road accident black spots. In this study we have used one of the pronounced method of Black spot analysis i.e. Corridor analysis in which whole section is divided in no. of segments and then improvement of black spots is done in sequential manner of each segment. By following this technique hazardous nature of whole stretch is rectified in a sequential order making whole stretch safe from one side which cannot be done in conventional method of black spots improvement. At last we have concluded our study by suggesting remedial measures for each black spot to make it safe.
Gamification Enhances Learning Experience of STEM Courses
Authors: Pilaniwala Pankaj
Published: August 2022

Abstract: This work-in-progress is about teaching the students multi-tables in Structured Query Language (SQL) using an interactive application. There are various readily available text books, online courses and educational online forums. Although these resources may provide effective learning, they commonly miss the interactivity component, which can add an element of engagement and possibly fun user experience while learning. This proposed work focuses on the interactive and fun aspects in learning the concepts and principles of SQL queries. The project currently includes a high-fidelity prototype implementation. The aim of the prototype is to provide students with information on SQL related concepts through interactive elements that aim to make the learning experience more engaging, fun and appealing. A star based rewarding mechanism was implemented for increasing motivation. Daily-life based metaphors were included in the modules for making it easier for the users to understand the concepts and making the learning experience more enjoyable. For testing and comparison purposes, a traditional paper-based teaching method was also created with the same content. Informal user study sessions were held in a classroom setting with 16 users. Results indicated that the interactive prototype implementation provided more effective learning and a more fun user experience than the traditional method.
UPS Powered by Solar Renewal Energy
Authors: Singh Asst. Prof. Ragini , Vishwakarma Dr. Santosh Kumar
Published: August 2022

Abstract: This paper includes the research and development of a solar powered UPS in India’s electrical market to satisfy the alternate energy source requirements of homes and tiny offices. During this paper circuit configuration, inspection, research pattern used and also the findings of the market study. The planning of the solar UPS includes a specially designed inverter circuit and a solar battery. The inverter circuit has been designed in keeping with the wants of domestic needs. The paper shows study of possibilities of design and functionality of a solar powered UPS. It gives concept that solar UPS is a highly efficient and successful alternative to electrical UPSs within the electrical market. There are two parts during this research first one is solar array which converts solar power into voltage and second is solar inverter which converts DC into electricity.
El campamento provisional de Antonio Viedma (Patagonia Atlántica, 1780) expectativas y desafíos para una arqueología de las ocupaciones coloniales de corta duración
Authors: Buscaglia Silvina
Published: August 2022

En el marco de tareas exploratorias asociadas a la empresa de colonización de la costa atlántica patagónica, Antonio Viedma establece en 1780 un campamento temporario en la margen sur de la ría Deseado (provincia de Santa Cruz, Argentina). Dado su carácter efímero, la localización de este asentamiento y sus características aún permanecen como una incógnita sin resolver desde el punto de vista arqueológico. De este modo, a partir de la integración de distintas líneas de evidencia tales como fuentes escritas, cartográficas, historiográficas, arqueológicas y ambientales, este artículo se propone, por un lado, reconstruir la historia ocupacional de dicho asentamiento. Por otro lado, a pesar del carácter temporario y la precariedad de la ocupación, busca evaluar el potencial arqueológico de la misma. Para ello se considerará la identificación de rasgos con una señal arqueológica más fuerte -i.e. un horno y un cementerio- que de hallarse no sólo facilitarían la identificación de la posible localización del asentamiento colonial, sino que brindarían valiosa información sobre el proyecto colonizador español en sus etapas iniciales.