bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychoneuroimmunomodulation - an immunotherapy strategy in complex neurorehabilitation
Authors: Starchenko A. A. , Khlunovsky A. N. , Komarets S. A. , Prilukov T. I.
Published: May 2022

The successes achieved by clinical immunology over the past decade have made it possible to solve various problems of a purely medical nature in the therapeutic and surgical clinics, and have stimulated the practical interest of many physicians in understanding the basic patterns of body reactivity. Understanding these regularities is already becoming essential in the daily work of physicians dealing with neurosurgical pathology.
Blink-Stuart-Morel syndrome
Authors: Ismagilov M. F. , Khasanova D. R. , Galimullina Z. A. , Sharayienidze D. M.
Published: May 2022

The Morgagni-Stewart-Morel syndrome (frontal hyperostosis syndrome, metabolic craniopathy) according to the classical description includes a triad of symptoms: thickening of the internal plate of the frontal bone, obesity and virilism.In 1762, Morgagni, opening the corpse of a 40-year-old woman, established a thickening of the inner plate of the frontal bone, and at the same time excessive obesity and male-type hairiness. He considered these signs not coexisting, but interconnected and described this observation.
Shvalev V. N., Sosunov A. A., Guski G. Morphological bases of cardiac innervation. — M.: Nauka, 1992. — 336 p.
Authors: Oslopov V. N.
Published: May 2022

The influence of Kazan medical schools not only on domestic, but also on foreign medicine is a well-known pattern, which is clearly manifested even now, in the year of the 180th anniversary of the higher medical educational institution of Kazan. An example of this is the book under review (with a dedication to the luminary of the Kazan neuro-histological school, B.I. Lavrentiev). We will not dwell on the analysis of the fundamental provisions of an embryological nature, displayed in the initial chapters of the book, and consider the main clinical aspects of the monograph, which are of interest to neurologists, cardiologists and other specialists in the field of clinical medicine.
Troshin VD, Troshin VM Acute disorders of cerebral circulation. - Lower. Novgorod: Sarpi. - 1993. - 270 p.
Authors: Gusev E. I.
Published: May 2022

The book under review is devoted to an urgent problem of modern medicine acute cerebrovascular accident, which is the main cause of high mortality, leading to severe disability of the population. Improving the phased system of medical care for patients with vascular lesions of the brain is the most important task of the nationwide program to combat cardiovascular diseases.
About the International Symposium on Cerebrolysin June 1, 1993, Moscow
Authors: Fischereder G. , Yudina A. V.
Published: May 2022

On June 1, 1993, the IV International Cerebrolysin Symposium was held in Moscow, organized by the All-Russian Society of Neurologists and the EBEWE Drug Factory (Austria), in which neurologists from Russia, the CIS countries, Austria and Germany took part.
Classifying Worldwide Standardized Seismograph Network Records Using a Simple Convolution Neural Network
Authors: Nagle-McNaughton Timothy P. , Ringler Adam T. , Anthony Robert E. , Alejandro Alexis C. B. , Wilson David C. , Wilgus Justin T.
Published: May 2022

The U.S. Geological Survey (USGS) maintains an archive of 189,180 digitized scans of analog seismic records from the World-Wide Standardized Seismograph Network (WWSSN). Although these scans have been made public, the archive is too large to manually review, and few researchers have utilized large numbers of these records. To facilitate further research using this historical dataset, we develop a simple convolutional neural network (CNN) that rapidly (∼4.75 s/film chip) classifies scanned film chip images (called “chips,” because they are individually cut segments of 70 mm film) into four categories of “interestingness” to earthquake seismologists based on the presence of earthquakes and other seismic signals in the record: “no interest,” “little interest,” “interest,” and “high interest.” The CNN, dubbed “Seismic Analog Record Network” (SARNet), can identify four types of seismic traces (“no events,” “minor events,” “major events,” and “errors”) in 200 × 200 pixel subcrops with an accuracy of 92% using a confidence threshold of 85%. SARNet then converts 100 random subcrops from each film chip into the overall classification of interestingness. In this task, SARNet performed as well as expert human classifiers in determining the film chip’s overall interest grade. Applying SARNet to 34,000 film chips in the WWSSN archive found that 21% of the images were of “high interest” and had an “indeterminate” rate of only 4%. Thus, the need for the manual review of images was reduced by 79%. Sorting of film chips derived from SARNet will expedite further exploration of the archive of digitized analog seismic records stored at the USGS.
Foreign Language Teachers’ Training in East Asia under the COVID-19 Pandemic
Authors: Paziura Nataliia
Published: May 2022

W artykule opisano doświadczenia krajów Azji Wschodniej w kształceniu nauczycieli języków obcych w trzech celach. Pierwszym z nich jest włączenie zasad i wartości wielokulturowego świata do programu nauczania na uniwersytetach. Drugi cel odnosi się do pytania, w jaki sposób wyszkolić odpowiednią liczbę wysoko wykwalifikowanych nauczycieli języków obcych, posiadających niezbędną wiedzę i umiejętności, aby przygotować studentów do życia w globalnym świecie oraz przyczynić się do rozwoju gospodarki światowej i krajowej. Trzeci cel obejmuje badanie, którego celem jest określenie tego, jak stosować aktywne metodologie w nauczaniu języków obcych i zapewnić studentom aktywne narzędzia nauczania na odległość, aby poprawić i zagwarantować jakość procesu nauczania–uczenia się. Doświadczenia krajów Azji Wschodniej pokazują potencjał kształcenia na odległość dla rozwoju kompetencji przekrojowych oraz zdolności studentów do projektowania i rozwiązywania złożonych problemów z kreatywnością i znajomością realiów społecznych i zawodowych. W artykule ukazano zalety metod i technik kształcenia na odległość, które zakładają połączoną odpowiedzialność studentów i nauczycieli w generowaniu wiedzy sprzyjającej ich rozwojowi zawodowemu jako nauczycieli języków obcych, odpowiadających potrzebom wynikającym ze zmian zachodzących w zglobalizowanym świecie.
Functioning of Preschool Educational Institutions under Pandemic Conditions
Authors: Kuzminskyi Anatolii
Published: May 2022

Celem przeprowadzonego badania było poznanie specyfiki funkcjonowania państwowych przedszkolnych placówek oświatowych podczas pandemii. Kwestie badawcze były następujące: tryb działalności, organizacja procesu edukacyjnego oraz cechy działalności pracowników przedszkolnej placówki oświatowej w warunkach kwarantanny. Metody badawcze: teoretyczne ‒ analiza źródeł psychologiczno-pedagogicznych i metodologicznych, badanie planów edukacyjnych, programów, zestawów materiałów pedagogiczno-metodologicznych, aktualnych stron internetowych przedszkolnych placówek oświatowych; empiryczne ‒ kwestionariusze, ankiety, wywiady, testy, obserwacje bezpośrednie i pośrednie, oceny eksperckie. Badaniu poddano cechy działalności przedszkolnych placówek oświatowych w warunkach funkcjonowania na odległość oraz w warunkach normalnej aktywności, ale z zachowaniem zasad kwarantanny. Wykazano trudności i komplikacje w pracy zespołów tych placówek oraz niedogodności dla dzieci i rodziców. W opracowaniu analizie poddano środki mające na celu wyeliminowanie negatywnych czynników uczenia się na odległość. Wskazano również zalecenia dotyczące specyfiki działań kierowników placówek oświatowych dla dzieci podczas pandemii.
Children with Special Educational Needs. Education during the Pandemic
Authors: Zasenko Viacheslav , Prokhorenko Lesia
Published: May 2022

Celem artykułu jest zwrócenie uwagi menedżerów, naukowców i praktyków placówek oświatowych specjalnych i włączających, a także rodziców i przedstawicieli organizacji publicznych na problemy edukacji w sytuacjach kryzysowych, w tym długoterminowej kwarantanny najsłabszej populacji każdego kraju, tzn. dzieci ze specjalnymi potrzebami edukacyjnymi, w tym dzieci niepełnosprawnych. Pokrótce scharakteryzowano ogólne aspekty reformowania i przesunięć w dziedzinie edukacji oraz nakreślono problematyczne zagadnienia dotyczące organizacyjnych, treściowych i metodycznych aspektów zapewniania funkcjonowania efektywnego systemu nauczania na odległość organizowanego dla takich dzieci. Jednocześnie dużą wagę przywiązuje się do zapewnienia organizacyjnych i merytoryczno-metodologicznych aspektów psychologiczno-pedagogicznego i korekcyjno-wychowawczego wsparcia dzieci ze specjalnymi potrzebami edukacyjnymi w kształceniu na odległość oraz zwraca się uwagę na wzmocnienie roli rodziny, z uwzględnieniem środowiska domowego, ochrony zdrowia, bezpieczeństwa i reżimu pedagogicznego. W artykule przedstawiono również dane na temat najnowszych osiągnięć edukacyjnych i metodologicznych oraz opisano konkretne kroki podjęte w celu zapewnienia efektywnej realizacji nauczania na odległość, a także zarysowano szereg problematycznych zagadnień i zaproponowano podjęcie działań mających na celu optymalizację tego procesu.
Hopes and challenges: Translational medical research in bladder cancer
Authors: Li Chong , Yang Zhao , Zhang Xu , Kang Xing , Yang Yin , Lei Dechun , Zhao Yunxia , Ning Shaojie
Published: May 2022

Bladder cancer is a complex disease and could be classified into non-muscle-invasive or muscle-invasive subtypes according to the distinct genetic background and clinical prognosis. It is necessary to find a non-invasive, economical, and efficient method for the diagnosis and treatment of bladder cancer. Translational medicine provides such an opportunity.Genomics, proteomics, molecular biology, and bioinformatics that aid in studying and exploring the mechanism of bladder cancer development, bladder cancer-related genes, signaling pathways, key molecules, or targets can be clearly used for the diagnosis and treatment of bladder cancer. Biomarkers have been developed as part of a new detection kit for the early screening, diagnosis, and recurrence monitoring of bladder cancer through translational medicine. In addition, targeted drugs and immunological preparations can be used for the treatment of bladder cancer and further improve its existing diagnosis, treatment, and prognosis.
Survival time distribution of advanced stage metastatic melanoma among whites and minority populations in Florida, 1996-2010.
Authors: N. Bebe Frederick , Hu Shasa , L. Brown Tony , L. Tulp Orien
Published: May 2022

Differences in genetic profiles and environmental exposure may impact on the prognostic factors of metastatic melanoma with major implications on the survival of minorities with advanced stage disease at presentation. This study determines the impact of the stage at diagnosis, tumor location, grade, and histologic type on overall survival time distribution among non–Hispanic Whites (NHW), HW and African– Americans (AA) in Florida. A dataset of 80,349 NHW, AA and HW Stage III and IV metastatic melanoma patients at presentation was obtained from the Florida Cancer Data System. Measures related to the impact of the stage at diagnosis, anatomic/primary site or tumor location, grade, and histologic type on overall survival time distribution across racial groups are reported. Data were analyzed using SAS. Mean time univariate and multivariate survival statistics across races were analyzed using Kaplan–Meir method and the nonparametric log-rank tests were used to test the homogeneity of survival curves. Significant differences in survival time are reported among the races in primary sites, histology, and stage at diagnosis, but not in terms of tumor grade; survival curve distributions were still significantly different even when adjustments were made for age, nodes, lymphatic invasion, and tumor size.
Sandwich type biosensor of ε-subunit of FoF1-ATPase for ultrasensitive-detection of Bladder cancer cell
Authors: Xu Zhang , Zhang Jinku , Kang Xing , Zhu Xuejia , Yan Yuhan , Yang Zhao , Li Chong
Published: May 2022

It was an important challenge for bladder cancer diagnosis that to design a sandwich-type biosensor was used for ultrasensitive detection of bladder cancer cell. This inspiration was from that ε subunit of Fo F1 -ATPase could be regarded as a switch of the Fo F1 -ATPase biosensor and its application on the ultrasensitive detection. There was only one ε subunit in one Fo F1 -ATPase, and this character could be used to design a real single antibody sandwich-type biosensor. Due to ε subunit of FoF1 -ATPase as an intramolecular rotation switch in the transition interchangeable motion, it was found that ε subunits can be interchanged between “rotor” and “stator” and remained its different activation at each status. Furthermore, Tip-chip device detection, which combined both a double antibody sandwich immunoassay and an intra-rotation switch of ε subunit FoF1-ATPase which plays a key role of the “rotor” and “stator” exchange hypothesis showing a signal amplification at space scale and a signal accumulation at time scale,was a powerful method. There were two states of the rotation switch model, one was the switch close state when the γ and ε subunits of FoF1-ATPase bound as one complex, and the other was the switch open state when the γε complex divided, and the intramolecular rotation coupling model based on the “binding change mechanism.”
LncRNA and Gene expression profiling of human bladder cancer
Authors: Yang Zhao , Wang Haifeng , Bai Suhang , Shen Zongyi , Bo Zhong , Yan Qiuyun , Cheng Dongxiao , Zhang Wei , Zhuang Jian , Wang Lingzhi , Yu Xinlu , Zhang Fuhan , Gao Ruonan , Yan Yuhan , Yu Changyuan , Li Chong
Published: May 2022

Bladder cancer (BC) is the most common urologic neoplasms with a high rate of recurrence. The formation of BC is a complicated process, resulting from smoke, drugs, or bladder inflammation. However, the underlying mechanisms of BC tumorigenesis remained unclear. In this study, we performed microarray analysis of three paired paratumor (PT) and tumor tissues from BC patients. In comparison with PT, BC tissues displayed 1136 upregulated and 1199 downregulated lncRNAs, and 1347 upregulated and 953 downregulated mRNAs. In addition, the upregulated mRNAs were focused in SNARE interactions, amino sugar and nucleotide sugar metabolism, and antigen processing pathways. The common downregulated genes were mainly focused in amino acid metabolism and drug metabolism signaling. More importantly, cytokinerelated genes were highly expressed in BC, which suggest that the dysregulation of immunoregulatory process and amino acid metabolism played a crucial role in the oncogenesis of BC.
The novel biomarkers in the diagnosis of prostate cancer
Authors: Liu Qi , Ding Jianjun , Liu Yifei , Jiang Zhenzuo , Li Lin , Xiao Bingxin , Wang Zhenjie
Published: May 2022

The prostate-specific antigen (PSA) as a biomarker for prostate cancer (PCa) diagnosis has been widely used in the clinic for several decades. However, PSA has a low specificity for PCa diagnosis, thereby several genes, blood, and urine-based biomarkers (such as sarcosine) underlying biology of PCa progression are being developed to improve the accuracy of PCa diagnosis. In the present review, we focus on novel PCa biomarkers, which are potentially superior to PSA in PCa screening and facilitate clinical PCa diagnosis. The early PCa screening with reliable biomarkers is critical in reducing the mortality of clinical PCa (high-risk PCa). For clinical insignificant PCa (low-risk PCa) patients and benign prostatic hyperplasia patients, biopsies should be avoided and disease progression should be monitored using non-invasive biomarkers.
Spontaneous and Chemically-induced Bladder Cancer Animal Model
Authors: Yang Zhao , Shen Zongyi , Zhang Nan , Bai Suhang , Wang Luyao , Naz Faiza , Chang Manxia , Chen Tiantong , Yu Changyuan , Li Chong
Published: May 2022

Investigations using animal model systems have been enlightening us with the biology underpinning the development of bladder cancer besides strengthening the existing therapy to improve the clinical outcome in patients. To date, spontaneous and chemical inductions are the classical methods in the generation of animal models of bladder cancer. Attributed to many benefits such as simple protocols and lower maintenance cost, these animal models are widely applied in the investigations of bladder cancer pathogenesis and screening of therapeutic drug. In this review, we give an overview of spontaneous- and chemically-induced bladder cancer animal models accompanying by the pros and cons of these two types of models. Furthermore, various chemical carcinogens used in the induction are discussed with the potential benefits and pitfalls in the establishment of animal models. This review will provide insightful information about the selection of the correct method in establishing the animal models of bladder cancer which are instrumental for studying potential therapeutic agents that target bladder cancer.
Latest Progress on RNA Methylation Modification in Hepatocellular Carcinoma
Authors: Dai Luo , Su Huizhao , Shu Gege , Lai Shihui , Wang Zhiqian , Dai Hongliang , Tang Bo
Published: May 2022

Hepatocellular carcinoma (HCC) is the most common malignant tumor worldwide, characterized by insidious onset as well as high incidence, recurrence, metastasis, and mortality rates. At present, there is no effective clinical treatment method except transplantation. The emergence and development of high throughput sequencing technologies in recent years has turned the epigenetics of cancer to spotlight; specifically, RNA methylation modification becomes a much discussed topic recently. RNA methylation modification plays a key role in the occurrence and development of HCC. This article reviews the relationship between different types of RNA methylation modification and HCC progression, which provides a new research direction for exploring the pathogenesis of HCC and developing new diagnostic methods and therapeutic targets.
Conversion Therapy for Locally Advanced Pancreatic Cancer: A Case Series and Literature Review
Authors: Wang Mingxing , Xu Yunyun , Yang Min , Jiang Dingyi , Chen Yunwang , Jiang Jiahong , Chen Zheling , Yang Liu
Published: May 2022

Patients with locally advanced pancreatic cancer account for a large proportion of patients with pancreatic cancer. According to the National Comprehensive Cancer Network guidelines, the patients with good performance status can undergo chemotherapy or chemoradiotherapy. However, a growing number of clinical studies suggested that aggressive surgical treatment after chemotherapy may lead to longer survival. In this case series, we report the effect of conversion therapy in four patients with locally advanced pancreatic cancer who visited Zhejiang Provincial People’s Hospital from January 2015 to October 2020. The clinical evaluation and prognosis of these patients after conversion therapy were analyzed and discussed in conjunction with relevant literature. The median overall survival time of the patients was 21.5 months. One patient who underwent surgery after chemotherapy achieved R0 resection. Another patient gave up the opportunity of surgery in the process of conversion therapy, but has been living with the tumor since. Taken together, the patients with locally advanced pancreatic cancer can benefit from conversion therapy in achieving R0 resection or long-term survival if surgery is not implemented.
Disease Uncertainty in Patients with Breast Cancer
Authors: Monterroza Dennys Isabel Muñoz , Jiménez Regina Cogollo , Noriega Aníbal Arteaga , Pérez Sandra Hernández
Published: May 2022

Breast cancer is a chronic disease, which will produce uncertainty, affects the overall health and damages the quality of life of patients. The purpose of this relevant, quantitative and cross-sectional study was to link the degree of uncertainty in patients with breast cancer based on sociodemographic and diagnostic variables. For convenience, 61 participants were sampled. Sociodemographic data questionnaire and Michelle Uncertainty Scale were used. Data processing and analysis were conducted by SPSS19, and the relationship between variables was tested by Chi Square test. Majority of the population in the study was between the ages of 50 and 69. 62% of people have regular uncertainty. The degree of uncertainty of the study population is related to the level of education and the time of diagnosis.
Potential of Nutraceutical in Preventing the Risk of Cancer and Metabolic Syndrome: From the Perspective of Nutritional Genomics
Authors: Alauddin Md. , Sultana Afroza , Kabir Yearul
Published: May 2022

Cancer and metabolic syndrome (MetS) are associated with genetic mutation and often seen as the results of altered metabolic signals. Several nutraceuticals have been found to be effective in treating these diseases in clinical practice through the modulation of biochemical and clinical endpoints associated with the pathogenesis of cancer and MetS. In line with the availability of multiple interventions that could counteract the metabolic changes, there is mounting evidence for nutraceuticals as potential complementary medicine for these diseases on the foundation of their multi-factorial nature. Although cancer and MetS are the major contributors to deaths globally, the therapeutic effects of nutraceuticals and the role of nutritional genetics and nutritional genomics in the treatment of these diseases have not yet been explored in-depth. In recent years, many studies revealed that certain compounds are able to halt the progression of cancer and MetS and subsequently improve individual health through the regulation of metabolic gene expression. In this review, we examine the relationship of nutraceutical, nutritional genetics, and nutritional genomics in the context of personalized medicine. The discrepancies in response to bioactive food components due to inter-individual variabilities in genetics, epigenetics, transcriptomics, proteomics, and metabolomics are also discussed.
Transferrin Receptor Serves as a Potential Target for Cancer Therapy
Authors: Tang Tian , Yang Jinhan , Jing Siyuan
Published: May 2022

Transferrin receptor (TfR) is a glycoprotein that transfers iron from the extracellular matrix to the intracellular environment. Due to the rapid proliferation need, the demand for iron in cancer cells is much greater than in normal cells, possibly explaining the upregulated TfR expression in cancer cells. The overexpression of TfR and its extracellular accessibility, ability to internalize, and central role in cancer cell make this receptor a potential target for antibody-mediated therapy. The TfR can be targeted indirectly by antibodies conjugated to anti-cancer agents or directly through the use of antibodies that disrupt the function of the receptor and induce Fc-mediated effector functions. This article reviews the developments of antibody-based cancer therapy targeting TfR.
Leiomyosarcoma of the bladder: A case report
Authors: Tan Zhiyong , Ning Li , Wang Jiansong , Huang Yinglong , Wang Haifeng , Zuo Yigang
Published: May 2022

Leiomyosarcomas (LMSs), malignant soft tissue tumor deriving from the mesoderm, account for <0.1% of all bladder malignancies. Conventionally, radical cystectomy with lymph node dissection has been advocated, though some series report that partial cystectomy is acceptable if a negative surgical margin is achieved. Here, we describe a 20-year-old young female presenting with LMS bladder. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a lobulated mass of 2.5 X 3.0 cm on the left lateral side of the bladder. The rest of the bladder appeared normal, with no gross pelvic lymphadenopathy. She performed with transurethral resection of bladder tumor (TURBT). She was diagnosed as LMS though histopathology and immunohistochemistry. Repeat-TURBT was implemented 30 days after the first surgery. Adjuvant chemotherapy was given (Ifosfamide 120 mg/m2 and Doxorubicin 20 mg/m2), and she has been doing well for 12 months of follow-up.
Combined Application of Fine-Needle Aspiration Cytology with BRAFV600E Mutation Screening in the Detection of Different Grades of Papillary Thyroid Carcinoma
Authors: Hao Ruizhe , Ji Yaming , Zhang Jinku , Zhou Bingjuan
Published: May 2022

The present study aimed to evaluate the application of fine-needle aspiration cytology (FNAC) of the thyroid coupled with the screening of serine/threonine-protein kinase B-Raf (BRAF) gene mutation in the detection of papillary thyroid carcinoma (PTC). From October 2016 to June 2019, 1244, liquid-based specimens originated from the patients diagnosed with PTC and benign lesions were collected from the Pathology Department of First Central Hospital of Baoding. BRAFV600E mutation was screened in all the liquid-based specimens using quantitative fluorescence polymerase chain reaction. Combined with the pathological results after surgery, the results of FNAC alone and FNAC combined with BRAFV600E screening results in PTC of different grades were compared and analyzed. Of the 1244 cases, there were 818 cases with definite cytological diagnosis and 426 cases with uncertain diagnoses. Combined with BRAFV600E screening, 36 out of 90 cases with atypical cells and 150 out of 223 suspected PTC were diagnosed as PTC. In conclusion, coupled with BRAFV600E mutation screening, the pre-operative detection rate of PTC can be increased in patients with atypical cells and suspected PTC which cannot be confirmed by pre-operative FNAC.
Bronchoscopic and Histologic Features of Patients with Lung Cancer
Authors: Sánchez Dainer Rogelio Acosta , Ferrer Miriannis Abad , Varona Eduardo Castillo , Smith Nancy Nápoles , García Adriana Cabo
Published: May 2022

Introduction: Lung cancer refers to a group of diseases resulting from the abnormal growth of cells of the breathing tract, in particular of the lung tissue. Objectives: To determine the bronchoscopic and histologic features useful in the confirmation of the diagnosis of these malignant neoplasms. Methods: We carried out a descriptive and cross-sectional investigation of 346 patients with lung cancer treated in the Pulmonology Service of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba during 2016 and 2017, to whom a bronchoscopy was performed. The variables included age, sex, diagnostic technique used, histopatologic diagnosis and most frequent localization. Results: Patients prevailed in the ages between 56 and 75 (66.1%), as well as the male sex (65.0%). The bronchial biopsy was the procedure that mostly revealed the presence of cancer (61.3%) and the most frequent histologic type was squamous cell carcinoma (67.8%). Conclusions: The importance of bronchoscopy and its diagnostic procedures was demonstrated to confirm the existence of the morbid process.
Containerization for creating reusable model code
Authors: Vanegas Ferro Manuela , Lee Allen , Pritchard Calvin , Barton C. Michael , Janssen Marco A.
Published: May 2022

Will you be able to run your computational models in the future? Even with well-documented code, this can be difficult due to changes in the software frameworks and operating systems that your code was built on. In this paper we discuss the use of containers to preserve code and their software dependencies to reproduce simulation results in the future. Containers are standalone lightweight packages of the original model software and their dependencies that can be run independent of the platform. As such they are suitable for reuse and sharing results. However, the use of containers is rare in the field of modeling social-environmental systems. We provide an introduction to the basic principles of containerization, argue why it would be beneficial if this tool became common practice in the field, describe a conceptual walkthrough to the process of containerizing a model, and reflect on near future directions of containerization workflows.
Platelet rich plasma or platelet rich fibrin: which is better in post extraction immediate implant placement followed by immediate loading?
Authors: Sachan Swapnil , Kumar Varun , Mehta Shruti , Sharma Deepali , Singh Prashant , Kushwah Pankaj S. , Sharma Kannu
Published: May 2022

Background: The study aimed to compare the clinical efficacy of platelet rich plasma (PRP) and platelet rich fibrin (PRF) used with phosphosilicate putty during immediate post extraction implant placement and immediate loading.

Methods: A prospective comparative clinical study was conducted on 20 adults. Two groups were made with 10 patients in each by random selection. Each patient required tooth extraction and replacement with immediate implantation and immediate loading. In Group 1 PRP was prepared from the patient's blood, mixed with alloplastic graft, and packed in peri-implant space and similarly in Group 2 PRF was prepared from the patient's blood and mixed with alloplastic graft in peri-implant space. All the patients were evaluated for postoperative pain, soft tissue analysis, implant mobility, and crestal bone height changes were observed for up to 6 months, using paired/independent t-test, and Chi-square test.

Results: It was seen that for pain on 1st postop day Group 1 had shown superior results than Group 2 after 7 days both groups showed good soft tissue healing. No significant difference was found in both groups when seen for implant mobility. The difference in crestal bone height gain in the first 3 months of Group 2 showed a remarkable height gain than in Group 1. And at 6th month overall crestal height gain difference between both groups was non-significant.

Conclusions: The autologous PRF can present new possibilities for enhanced healing and functional recovery over PRP during immediate post extractive implantation and immediate loading.
Entre cacos y cuicos. Representaciones en la prensa de la policía en Guadalajara (1879-1890)
Authors: Herrera Guevara Sebastián Porfirio
Published: May 2022

El presente artículo muestra un panorama profuso de las representaciones que aparecieron en la prensa tapatía sobre la policía urbana de Guadalajara. Se inicia con una reflexión de las representaciones sobre la creciente criminalidad en la ciudad y los aspectos socioeconómicos que la explicaban. Después se abordan las representaciones sobre los reclamos de la ineficiencia policial, su falta de integrantes suficientes y el desamparo en el que se encontraban los habitantes de la capital de Jalisco. El apartado siguiente se concentra en las representaciones vertidas sobre la estructura policial, las carencias en las condiciones de trabajo y la creciente petición para una renovación de fondo de la institución a través de un nuevo reglamento. Por último, se concluye con un apartado que aborda estas reflexiones a nivel individuo, tomando la cobertura cotidiana del accionar policial, desde la ineficacia, los abusos policiales y las contadas buenas acciones.
Viajes para trabajadores. Un experimento peruano en los inicios del turismo social (1946-1948)
Authors: Armas Asín Fernando
Published: May 2022

Este artículo trabaja, en un contexto de desarrollo del turismo social, el caso de un programa implementado por el gobierno de Perú, que buscó incorporar a los trabajadores al beneficio del descanso y los viajes. Recoge los resultados de esa experiencia y con ello pretende mostrar cómo programas mal diseñados terminan beneficiando a un grupo social por sobre otros. Este trabajo sirve para entender un aspecto relevante de las políticas implementadas por los Estados a mediados del siglo XX, en un contexto político y social particularmente difícil en América Latina.
Reinvestigating the Co-Movements Between Stock Market and Exchange Rates: An Augmented Vector Autoregression Analysis
Authors: Akinkunmi Mustapha Abiodun , Bello Saheed
Published: May 2022

Empirical works on the stock market exchange rate nexus remain scanty in the managed floating exchange rate environment like Nigeria. Thus, our paper contributes to the scanty literature by analyzing how the COVID19 pandemic shapes the existing link in the oil-rich countries like Nigeria using a time series approach based on daily data spanning between 2017 and 2021. The paper investigates a Granger causality relationship in the specified VAR model by implementing the Toda and Yamamoto procedures while determining the direction of the causality through our impulse response analysis. Our findings show unidirectional causality from exchange rates to the stock market in the pandemic but no causality before the pandemic. This suggests that the exchange rate affects the performance of the Nigerian stock market in the pandemic period. Therefore, the Nigerian stock market and the exchange rate should not be considered as alternative strategies to mitigate risk during the crisis periods.
THE PROCESS OF COMPREHENSION: THE ROLE OF READING LITERARY TEXTS FOR ENHANCING THE BASIC LANGUAGE SKILLS
Authors: Waheed Saima , Bhatti Zafar Iqbal , Khan Anila
Published: May 2022

Purpose of the study: The targets of the review were to figure out the effect of perusing literary texts on the improvement of language abilities, working of jargon, punctuation, grammar, composing articulation and the highlight composing abilities of the ESL students. The ESL students deal with a ton of issues in language learning, especially during the time spent composing abilities; because the most common way of composing needs its very own topic, a circumstance, which customary course books loaded with syntax practices can't give. Methodology: The data-gathering instruments include Questionnaires; an Open-ended Questionnaire, a Close-ended Questionnaire and a Semi-structured Interview. This research was qualitative. For the convenience of the current research, the researcher primarily gathered open-ended items from the respondents through an open-ended questionnaire and semi-structured interview schedule from students and teachers respectively. Main Findings: In order to take maximum benefits from literature for language learning especially writing skills, activity-based leaning needs to be given emphasis in the classroom. But there should be systematic criteria for selection of classroom activities. Applications of the study: This study provides an awareness of the way language is used in literary discourse for the conveying of unique message.The students can study literature for only language learning. Literature should first succeed as literary experience no matter how much it helps in language learning. Novelty/Originality of the study: This study can pave grounds for the ESL learners in the language classroom using literary texts as the material especially designed for the writing activities (for children aged 5-12 years).This study would increase ESL learners’ interest in both reading literary texts and doing writing tasks based on them.
Saberes e fazeres educacionais, culturais e profissionais presentes nas várias esferas das relações sociais
Authors: Silva Pedro Rodolfo Fernandes da , Andrade Aldair Oliveira de , Siqueira Antonio Marcos de Oliveira , Araújo Wagner dos Reis Marques , Andrade Roberta Ferreira Coelho de
Published: May 2022

O presente número da REVES – Revista de Relações Sociais, v. 5, n. 1, conta com artigos das diversas áreas das ciências humanas e sociais, tendo como fio condutor dessa tessitura os saberes e fazeres educacionais, culturais e profissionais presentes nas várias esferas das relações sociais, apresentando conhecimentos, práticas, procedimentos e processos utilizados nas sociedades. Nesse número, a pesquisa voltada para a Educação Ambiental, seus saberes e práticas, desponta como temática central, oportunizando conhecimentos necessários aos atores sociais que atuam, direta ou indiretamente, na educação e formação de crianças e jovens, bem como para os que atuam na liderança de comunidades, pois é premente a conscientização das pessoas quanto à necessidade de que as ações humanas sejam cada vez mais pensadas e praticadas objetivando a redução dos danos ao ambiente e da harmonia entre homem e natureza. Necessário também ressaltar a interdisciplinaridade que marca os artigos que compõem esse número, indicando a riqueza das temáticas e das abordagens presentes nas pesquisas, bem como a multiplicidade dos saberes e fazeres e a construção coletiva e diversa do conhecimento e das práticas sociais.
​Moringa oleifera: The Miracle Tree and its Potential as Non-conventional Animal Feed: A Review
Authors: Rizwan Nazish , Rizwan Danish , Banday M.T.
Published: May 2022

Moringa oleifera, a member of the plant family Moringaceae, has been recognized to have an abundance of nutrients and bioactive substances with the potential to positively affect health. Moringa has proven to be a versatile plant, with every part of it being used as either a food or a therapeutic agent. The favorable results of different scientific investigations on the use of Moringa in human nutrition have prompted a quest to investigate its potential application in the livestock sector as an alternative to traditional animal feed. Moringa, being an excellent source of nutrients, particularly proteins, can be used as a source of protein in animal diets or as an alternative to conventional livestock feed and fodder. Many research articles have recently been published suggesting that Moringa can be utilized as an unconventional feed or as a fortification agent in animal feeds at inclusion levels that have no negative impact on health, survival, mortality, growth rate, or reproduction. Furthermore, Moringa oleifera has been discovered to have an important role in the management of some animal illnesses, particularly avian coccidiosis, by exhibiting anti-coccidial properties.
Developing cooling system application for the immobile patients
Authors: Ramiz Salama
Published: May 2022

There is an increase in the use of automated systems as technology moves forward towards the 21st century; people are trying to make use of their time the most with modern technology, with Microcontrollers becoming a necessity. Arduino, the popular portable microcontroller is one of the best currently in terms of making fast, efficient, automated devices that help in day-to-day life. This paper aims to present the ARDUINO-powered COOLING SYSTEMS, which can be applied in different areas including daily used objects. The use of this as COOLING will improve human life while educating people on the uses of microcontrollers. This book defines the Arduino microcontroller and the Arduino idea. Their methodology was to share microcontroller-based equipment and plan stages to share thoughts and advance development. To meet the wide group of onlookers, the document has been segmented to fulfill the need of everyone. The document contains numerous equipment guides to help the peruser ascertain all assortment of frameworks.
 
Keywords: ARDUINO; cooling system; Liquid Crystal Display ( LCD); Microcontroller; sensor.
Technical Aspects of e-Waste Management
Authors: Avis William
Published: May 2022

Population growth, increasing prosperity and changing consumer habits globally are increasing demand for consumer electronics. Further to this, rapid changes in technology, falling prices, increased affordability and consumer appetite for new products have exacerbated e-waste management challenges and seen millions of tons of electronic devices become obsolete. This rapid literature review collates evidence from academic, policy focussed and grey literature on the technical aspects e-waste value chains. The report should be read in conjunction with two earlier reports on e-waste management1. E-waste is any electrical or electronic equipment, including all components, subassemblies and consumables, which are part of the equipment at the time the equipment becomes waste. The exact treatment of Waste from Electrical and Electronic Equipment (WEEE) can vary enormously according to the category of WEEE and technology that is used. Electrical and electronic items contain a wide variety of materials. As a result of this complex mix of product types and materials, some of which are hazardous (including arsenic, cadmium, lead and mercury and certain flame retardants) multiple approaches to WEEE are required, each with specific technical guidelines. This report is structured as follows: Section two provides an introduction to the technical aspects of e-waste management, including a reflection on the challenges and complexities of managing a range of product types involving a range of components and pollutants. Section three provides an annotated bibliography of key readings that discuss elements of the technical aspects of managing e-waste. This bibliography includes readings on national guidelines, training manuals and technical notes produced by the Basel convention and courses. WEEE recycling can be a complex and multifaced process. In order to manage e-waste effectively, the following must be in place Legislative and regulatory frameworks Waste Prevention and minimisation guidelines Identification of waste mechanisms Sampling, analysis and monitoring expertise Handling, collection, packaging, labelling, transportation and storage guidelines Environmentally sound disposal guidelines Management is further complicated by the speed of technological advance with technologies becoming redundant much sooner than initially planned. Case studies show that the average actual lifetimes of certain electronic products are at least 2.3 years shorter than either their designed or desired lifetimes.
Relationship between Workplace Fun and Job Satisfaction among University Administrative Staff: Does Perceived Organizational Support Matter?
Authors: Edosomwan Henry Samuel
Published: May 2022

Research on the underlying factors connecting workplace fun and job satisfaction in public organizations is in dearth. Based on the aforementioned, this study examined the moderating effect of perceived organizational support (POS) in the relationship between workplace fun and job satisfaction. A cross-sectional design was adopted for the study. The convenience sampling technique was used for selecting 167 university administrative staff consisting of 58 males and 109 females. Standardized self-report measures were adopted for data collection while the regression analysis (complemented with model 1 of Hayes' PROCESS Macro) was used for testing the hypotheses via the IBM-SPSS version 25. The results indicated that workplace fun positively and significantly predicted job satisfaction. POS was positively and significantly related to job satisfaction but did not moderate the relationship between workplace fun and job satisfaction. The research findings suggest that workplace fun and POS are salient factors for the experience of satisfaction at work. It is recommended that workplace fun should be encouraged and supported by the organization as this has a unique way of improving job satisfaction.
The submental island pedicled flap and supraclavicular artery island flap in a free flap practice
Authors: Hussaini Adnan S. , Patel Urjeet A.
Published: May 2022

Reconstruction of head and neck defects is a delicate endeavor that poses numerous intrinsic and extrinsic challenges, which are currently magnified by rising health care costs and limitations in system resources. Current trends in the United States heavily favor the use of free tissue transfer over locoregional pedicles flaps (LRPF); however, the latter group is often undervalued, offering high utility, practicality, and cost-efficiency whilst providing equivalent results. The submental island flap and supraclavicular artery island flap are two LRPF that should be in the arsenal of the modern reconstructive surgeon.
RIP140 regulates POLK gene expression and the response to alkylating drugs in colon cancer cells
Authors: Palassin Pascale , Lapierre Marion , Bonnet Sandrine , Pillaire Marie-Jeanne , Győrffy Balázs , Teyssier Catherine , Jalaguier Stéphan , Hoffmann Jean-Sébastien , Cavaillès Vincent , Castet-Nicolas Audrey
Published: May 2022

Aim: The transcription factor RIP140 (receptor interacting protein of 140 kDa) is involved in intestinal tumorigenesis. It plays a role in the control of microsatellite instability (MSI), through the regulation of MSH2 and MSH6 gene expression. The aim of this study was to explore its effect on the expression of POLK, the gene encoding the specialized translesion synthesis (TLS) DNA polymerase κ known to perform accurate DNA synthesis at microsatellites. Methods: Different mouse models and engineered human colorectal cancer (CRC) cell lines were used to analyze by RT-qPCR, while Western blotting and luciferase assays were used to elucidate the role of RIP140 on POLK gene expression. Published DNA microarray datasets were reanalyzed. The in vitro sensitivity of CRC cells to methyl methane sulfonate and cisplatin was determined. Results: RIP140 positively regulates, at the transcriptional level, the expression of the POLK gene, and this effect involves, at least partly, the p53 tumor suppressor. In different cohorts of CRC biopsies (with or without MSI), a strong positive correlation was observed between RIP140 and POLK gene expression. In connection with its effect on POLK levels and the TLS function of this polymerase, the cellular response to methyl methane sulfonate was increased in cells lacking the Rip140 gene. Finally, the association of RIP140 expression with better overall survival of CRC patients was observed only when the corresponding tumors exhibited low levels of POLK, thus strengthening the functional link between the two genes in human CRC. Conclusion: The regulation of POLK gene expression by RIP140 could thus contribute to the maintenance of microsatellite stability, and more generally to the control of genome integrity.
AEROBIOLOGIA FÚNGICA DAS SALAS DE LIMPEZA E DESINFECÇÃO DE UM CENTRO UNIVERSITÁRIO
Authors: Vitor Marílya Gabriella Correia , Lima Neto Manoel Modesto de , Silva Jane Kelly Marques da , Peixoto Fernanda Braga , Peixoto Marcílio Otávio Brandão , Santos Júnior Claudio José dos , Souza Aryanna Kelly Pinheiro
Published: May 2022

A contaminação por agentes biológicos ocorre principalmente através da recirculação do ar em ambientes fechados. O objetivo deste trabalho foi identificar a aeromicrobiologia fúngica das salas de limpeza de materiais odontológicos de um Centro Universitário de Maceió Alagoas. O estudo é do tipo experimental “in vitro”. Foi realizado nas duas salas de limpeza de materiais odontológicos do Centro Universitário Cesmac. Os dois ambientes possuem condicionadores de ar. Foi realizada a identificação dos fungos através da técnica de sedimentação passiva em placas de Petri com o meio Ágar Sabouraud enriquecido com Cloranfenicol. Os meios foram expostos antes e após a limpeza dos materiais odontológicos. As placas tiveram exposição de 20 minutos. Dentre os fungos isolados pode-se visualizar com maior frequência de Mycelia Sterilia com 64 (57,14%) UFC, seguido pelos gêneros Aspergilus sp. com 18 (16,07%) UFC, Penicilium sp. com 9 (8,03%) UFC, tendo em menor quantidade, Aureobasidium sp. e Geotrichum sp. ambos com 4 (3,57%) UFC; Aspergillus do grupo niger, Cladosporium sp. e Scopulariopsis sp. com 3 (2,67%) UFC cada gênero/espécie; Fusarium sp., Candida sp, e Alternaria sp. com 1 (0,89%) UFC para cada. Conclui-se que apesar de haver a higienização regular dos sistemas de ar condicionado, ainda houve grande predominância de fungos patogênicos nos ambientes, no que acaba por se tornar um grande fator de risco, especialmente aos indivíduos com imunidade deprimida.