bluuebunny/crossref_metadata_2025 huggingface dataset:
The Lipid Invasion Model: Growing Evidence for This New Explanation of Alzheimer’s Disease
Authors: Rudge Jonathan D’Arcy
Published: June 2023

The Lipid Invasion Model (LIM) is a new hypothesis for Alzheimer’s disease (AD) which argues that AD is a result of external lipid invasion to the brain, following damage to the blood-brain barrier (BBB). The LIM provides a comprehensive explanation of the observed neuropathologies associated with the disease, including the lipid irregularities first described by Alois Alzheimer himself, and accounts for the wide range of risk factors now identified with AD, all of which are also associated with damage to the BBB. This article summarizes the main arguments of the LIM, and new evidence and arguments in support of it. The LIM incorporates and extends the amyloid hypothesis, the current main explanation of the disease, but argues that the greatest cause of late-onset AD is not amyloid-β (Aβ) but bad cholesterol and free fatty acids, let into the brain by a damaged BBB. It suggests that the focus on Aβ is the reason why we have made so little progress in treating the disease in the last 30 years. As well as offering new perspectives for further research into the diagnosis, prevention, and treatment of AD, based on protecting and repairing the BBB, the LIM provides potential new insights into other neurodegenerative diseases such as Parkinson’s disease and amyotrophic lateral sclerosis/motor neuron disease.
Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2023 Update
Authors: McFarthing Kevin , Buff Susan , Rafaloff Gary , Fiske Brian , Mursaleen Leah , Fuest Rosie , Wyse Richard K. , Stott Simon R.W.
Published: June 2023

Background:

Since 2020, annual reports on the clinical development of new drug-based therapies for the neurodegenerative condition of Parkinson’s disease (PD) have been generated. These reviews have followed the progress of both “symptomatic treatments” (ST – improves/reduces symptoms of the condition) and “disease modifying treatments” (DMT - attempts to delay/slow progression by addressing the underlying biology of PD). Additional efforts have been made to further categorize these experimental treatments based on their mechanisms of action and class of drug.

Methods:

A dataset of clinical trials for drug therapies in PD was obtained using trial data downloaded from the ClinicalTrials.gov online registry. A breakdown analysis of all the studies that were active as of January 31st, 2023, was conducted.

Results:

There was a total of 139 clinical trials registered on the ClinicalTrials.gov website as active (with 35 trials newly registered since our last report). Of these trials, 76 (55%) were considered ST and 63 (45%) were designated DMT. Similar to previous years, approximately a third of the studies were in Phase 1 ( n = 47; 34%), half ( n = 72, 52%) were in Phase 2 and there were 20 (14%) studies in Phase 3. Novel therapies again represented the most dominant group of experimental treatments in this year’s report with 58 (42%) trials testing new agents. Repurposed drugs are present in a third ( n = 49, 35%) of trials, with reformulations and new claims representing 19% and 4% of studies, respectively.

Conclusions:

Our fourth annual review of active clinical trials evaluating ST and DMT therapeutics for PD demonstrates that the drug development pipeline is dynamic and evolving. The slow progress and lack of agents transitioning from Phase 2 to Phase 3 is concerning, but collective efforts by various stakeholders are being made to accelerate the clinical trial process, with the aim of bringing new therapies to the PD community sooner.
An international scoping review of factors impacting self-employment outcomes for individuals with disabilities
Authors: Avellone Lauren , Malouf Emily , Taylor Joshua P. , Whittenburg Holly
Published: June 2023

BACKGROUND: Self-employment is a flexible alternative to traditional workforce positions. Individuals with disabilities are self-employed at higher rates than individuals without disabilities, mainly because self-employment circumnavigates many of the commonly experienced barriers individuals with disabilities face when pursuing more typical employment situations. Still, little is known about factors that impact successful self-employment outcomes. OBJECTIVE: The purpose of this study was to identify factors that facilitate or hinder self-employment outcomes for individuals with cognitive and physical disabilities. METHOD: A scoping review of the empirical literature was conducted to examine individual/system level, programmatic, and key themes within lived experiences that affect self-employment outcomes. RESULTS: A total of 40 articles were included in the final sample representing both national and international research efforts. Findings indicated that a multitude of factors affect self-employment outcomes including demographics (e.g., gender, race, age, disability), social network, financial standing and work history, personal motivation, interagency collaboration, services provided (e.g., business plan development and mentorship), and barriers (e.g., lack of training and services). CONCLUSION: There are a number of known variables that promote self-employment outcomes. Implications for future research, policy and practice are discussed.
Understanding the provision of self-employment for people with disabilities in the State Vocational Rehabilitation Services Program: A policy review
Authors: Hansen Kathryn , Keeton Beth , Jones Joseph
Published: June 2023

BACKGROUND: State vocational rehabilitation (VR) agencies play a critical role in helping people with disabilities gain employment; however, self-employment remains an infrequent outcome for VR participants even though self-employment rates are disproportionately higher for people with disabilities than the general population. OBJECTIVE: The study provides a broad review and analysis of state VR self-employment policies to identify barriers that impede equitable access to self-employment services and provide recommendations on how to address these nationally. METHODS: The policy analysis included reviewing 73 VR state and territory agency’s policies across the country, using data from the RSA-911 self-employment data and other sources about the self-employment process through VR agencies. RESULTS: Currently less than 2% of VR participants exit into self-employment nationwide. Three policy areas that could increase outcomes for self-employment are self-employment assessments, market analysis or business planning requirements, and self-employment funding and financing guidelines. CONCLUSION: Policymakers need to explore new opportunities to address unintended barriers and increase equitable access to self-employment such as replacing trait focused self-employment assessments, providing technical assistance from the beginning of the self-employment process, and develop funding policies that better align with those for wage employment services.
Recognising and Responding to Physical and Mental Health Issues in Neurodivergent Females
Authors: Kelly Clive , Martin Ren , Taylor Rachael
Published: June 2023

People experience life and interact with others in many ways. The term ‘neurodivergence’ refers to variations from what is considered typical or normal. Research and education into neurodivergent conditions in females is essential in informing a reassessment of clinicians’ present approach to those who present with multiple unexplained symptoms. Neurodivergence may influence a person’s style of communication, learning, attitudes, and behaviour, and they may experience inequity and rejection. A formal diagnosis improves access to support services and helps them and their family better understand themselves and the challenges they face. Neurodivergent females are especially prone to many physical and psychological health issues, and it is essential that clinicians learn to recognise and respond to these. This commentary highlights the relative lack of research into clinical aspects of neurodivergent conditions in females, suggesting how clinicians might increase their awareness to mutual benefit.
Supplementation with Vitamin D, Zinc, and Quercetin to Treat COVID-19: A Case Report
Authors: Martin Brett
Published: June 2023

Objective: The purpose of this case report is to analyze the treatment of a patient with COVID-19 using the combination of vitamin D, zinc, and quercetin.

Clinical Features: A 23-year-old female presented with COVID-19. She had been triple vaccinated with Moderna. Advil alleviated her fever, myalgias, pharyngitis, and headache. However, her symptoms of a productive cough, nasal congestion, fatigue, ageusia, and anosmia were unchanged. Her cough and nasal interfered with her sleep.

Intervention/Outcome: The combination of 5,000 IU of vitamin D, 100 mg of zinc, and 1,000 mg of quercetin 3 times a day with meals was utilized to control her symptoms. After 1 day of supplementation, she experienced an improvement in her fatigue and nasal congestion. After 3 days of supplementation, her cough abated and her fatigue, nasal congestion, ageusia, and anosmia were greatly improved. Complete resolution of symptoms occurred after 6 days of treatment.

Conclusion: The combination of vitamin D, zinc, and quercetin may have contributed to the resolution of COVID-19.
Examining Off-Label Prescribing of Ozempic for Weight-Loss
Authors: Wojtara Magda , Syeda Yusra , Mozgała Nikodem , Mazumder Ashmita
Published: June 2023

Ozempic (semaglutide) is a US Food and Drug Administration (FDA) approved medication for the treatment of type 2 diabetes and more recently has been utilized in the management of chronic weight management in some patients. It belongs to a broader class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists which help to lower the blood sugar levels of individuals with type 2 diabetes. There has been growing recent interest, especially on social media platforms such as Tik Tok, about the use of Ozempic for weight loss. While Ozempic has shown promising results in clinical trials for weight loss, there are several potential risks and concerns associated with its use. There is a lack of adequate long-term safety data on its use specifically for weight loss. Growing concerns around Ozempic include its potential misuse without proper medical supervision or its prescription off-label for weight loss leading to prescription shortages. Both of these are pressing concerns surrounding the use of this medication without medical need and ultimately resulting in risky and unnecessary medical interventions. Further study is needed in order to assess and communicate the long-term effects of Ozempic for weight loss, and health policy changes to ensure safe access.
Pengaruh Leader-Member Exchange, Quality of Work-Life, dan Motivasi Intrinsik terhadap Organization Citizenshi Behavior pada Karyawan PT Pradipta Bhumi Konstruksi Bantul
Authors: Dewi Misthika , Prayekti Prayekti
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pertukaran anggota kepemimpinan, kualitas kehidupan kerja, dan motivasi intrinsik terhadap perilaku anggota organisasi (OCB) di PT Pradipta Bhumi Construction Bantul. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan populasi seluruh karyawan PT. PT. Konstruksi Pradipta Bhumi. Pengambilan sampel menggunakan teknik sensus, analisis data menggunakan analisis deskriptif, uji asumsi klasik, analisis regresi linier berganda, pengujian hipotesis, koefisien determinasi. Hasil penelitian menunjukkan bahwa pertukaran anggota pemimpin, kualitas kehidupan kerja, dan motivasi intrinsik secara simultan berpengaruh signifikan terhadap perilaku organisasi kewarganegaraan.
Analisis Deskriptif Capaian Kinerja: Bukti Implementasi Beban Kerja Dosen
Authors: Mawardi Syamsi , Wahyudi Wahyudi
Published: June 2023

Kemajuan teknologi yang pesat menjadi penyebab ketatnya Kemenristekdikti dalam menilai kinerja Perguruan Tinggi, bahkan sejak tahun 2018 Kemenristekdikti telah mencanangkan sistem penilaian Output-Outcome Perbasi. Hal itu dilakukan sebagai salah satu jawaban atas tantangan modernisasi. Dengan ketatnya penilaian tersebut, Kemenristekdikti mengajak seluruh perguruan tinggi negeri dan swasta untuk realistis dalam menyelenggarakan pendidikan, dimana proses pendidikan dilakukan secara benar dengan orientasi untuk menghasilkan lulusan yang dibutuhkan dunia pendidikan. bekerja, melakukan penelitian yang berorientasi output berupa inovasi produk atau kebijakan, dan terlibat langsung dalam pemecahan masalah yang ada di masyarakat melalui program pengabdian kepada masyarakat. Oleh karena itu, penelitian ini dilakukan sebagai upaya untuk mengkaji sejauh mana kontribusi kinerja dosen terhadap prestasi perguruan tinggi, dalam hal ini akreditasi. Untuk dapat mengkaji hal-hal tersebut maka dilakukan pendekatan penelitian yaitu berbentuk deskriptif kuantitatif. Dimana, penelitian ini lebih menekankan pada pengungkapan kondisi yang terjadi di lapangan mengenai praktek Tri Dharma Perguruan Tinggi, sehingga dapat diketahui faktor apa saja yang mempengaruhinya. Hasil kajian menunjukkan bahwa produktivitas dosen dalam pengajaran, penelitian dan pengabdian kepada masyarakat tergolong kurang optimal. Hal ini terlihat pada data publikasi buku, jurnal internasional, sitasi dan hak kekayaan intelektual. Keadaan ini menunjukkan bahwa semangat dosen untuk berprestasi masih rendah.
Analysis Of Language Acquisition in The Qur'an Psycholinguistic Perspectives in Education
Authors: Sunaryo Irfan , Hidayat Nur , Iskandar Rusdy , Oktavia Lusi , Huda Nurul , Rizki Afifah
Published: June 2023

This study aims to investigate language acquisition in the Qur'an in more detail from a psycholinguistic perspective. A psycholinguistic lens is used to explore language in this article. This study chose a descriptive qualitative approach as the research methodology. The literature review uses the data source, which looks for data sources in papers and books from scientific journals related to the previous research. The data collection method used in this research is a library or literature review. The material to be observed is journal articles that discuss language acquisition in the Qur'an from a psycholinguistic perspective. According to the findings of this study, Arabic is the language of religion and international communication in the current global era. Therefore, it cannot be denied that learning Arabic is very important for understanding religious teachings, especially the teachings contained in the Qur'an. Psycholinguistic understanding is essential for language learning because it allows one to understand the psychological processes that occur when someone speaks, reads, writes, or listens, as well as the processes that happen when someone says, reads, and reports. This understanding allows one to see alternative psychological solutions to language learning problems
The Disaster of Literacy: Prevention of News Forwarding Tendencies on Social Media
Authors: Anwar Anwar , Suzana ‪Yenny
Published: June 2023

One of the indicators of insufficient literacy knowledge in society is their susceptibility to deal with conflict, hate speech, hoax, and defamation. This article represents research findings aimed at exploring the literacy skills of the academic community of IAIN Langsa in accepting disastrous information on news that leads to harmful and misleading content. Moreover, it also aimed at disseminating preventive information for not forwarding news obtained from social media, which is used as a medium of information, to reduce the disaster risks that trigger a moral loss in society. This research applied descriptive methods. The research subjects were students, lecturers, and staff of IAIN Langsa. Data were collected using a questionnaire via Google form and semi-structured interviews.
The Urgency of Education as a Human Investment in Improving the Quality of Education at SMP Negeri 8 Langsa City
Authors: Arwinsyah Diki
Published: June 2023

This article's topic is centered on elements of basic education that can enhance the human development index's quality. The significance of discussing is connected to investing in education or using it as a major source of capital to achieve a country's development objectives. The discussion in this article has led to a classification of the four characteristics of students, educators, education staff, and parents or the community as human resources as investment capital in education at SMP Negeri 8 Langsa. Government support still holds a disproportionate amount of the investment in education funding in SMP Negeri eight Langsa. The return on investment in education, in the form of graduates, can rise even further, enhancing peoples' quality of life. At SMP Negeri 8 Langsa, the use of human resources as educational investment capital is divided into four categories. Aspects relating to students, teachers, employees, parents, or the community. Based on the school's potential, these four elements serve as the total capital for implementing, growing, and improving the quality of education
Effects of a Mindfulness Intervention on Nurse Burnout
Authors:   ,   Andrews University, Elanges Sandra
Published: June 2023

Background Before the COVID-19 pandemic, nurse retention was a known issue; current nurse retention has worsened. This project examined the burnout of nurses and offered some potential interventions to assist in retaining nurses in the field of nursing. Purpose To determine whether a six-week online mindfulness intervention improved the Oldenburg Burnout Inventory (OLBI) scores of nurse participants. Methods This project used a convenience snowball sample of participants recruited through social media platforms including Reddit, Twitter, Facebook, TikTok, AllNurses, and word of mouth. This quantitative quasi-experimental design utilized pre- and post-testing to measure baseline burnout and evaluate the intervention’s efficacy. The Theory of Planned Behavior informed the conceptual framework and Dorothea Orem’s Self-Care Deficit Theory served as the theoretical framework. Results The project recruited 65 nurses, with 44 nurses completing the project. Results from pre- and post-testing OLBI demonstrated the mindfulness intervention was successful at reducing OLBI scores by 2.52 points on average. Initial ACEs/PCEs scores were assessed to determine whether those with increased ACEs scores reported a reduction in OLBI scores, however, no correlation could be determined.
Impact of Motivational Interviewing on Body Mass Index
Authors:   ,   Andrews University, Thompson Tajsier
Published: June 2023

Introduction Being overweight and obese has become a common lifestyle. More than half of American adults are overweight and more than a quarter of overweight adults are obese. Despite this overwhelming statistic, weight-loss coaching by primary care providers is usually disregarded due to time constraints and lack of skills to motivate patients to reach weight-loss goals. Motivational interviewing (MI) focuses on helping people investigate and overcome ambivalence toward healthy lifestyle modifications by helping them to explore their weaknesses, strengths, and preferences in an effort to facilitate behavioral changes. Objective The primary objective of this project is to assess the effectiveness of MI as a coaching technique to decrease body mass index (BMI). Method The thirty-three participants for this project were selected through a random systematic sampling method. Those who met the inclusion criteria were systematically assigned to either the control or experimental group (odd number participants [1, 3, 5 ...] were selected for the experimental group; and even number participants [2, 4, 6 ...] were selected for the control group). The relationship between MI and a potential reduction in BMI was evaluated by performing an independent sample t-test and two-group pre-test/post-test design in order to analyze the mean difference in BMI for the two groups. At the end of a 6-week period, the treatment group chose and implemented behavior modifications that aided in weight loss after receiving MI. During the same 6-week period, the control group continued without MI as an intervention. Results There was no significant difference, t(31) = 1.62, p = 0.58 in mean pre-/post-BMI outcomes for participants who received MI as an intervention during a brief consultation. The BMI outcomes for the experimental group were M = 33.09, SD = 6.5; and for the control group were M = 29.8, SD=5.05; 95% CI. Conclusion Weight loss is a battle that many Americans face (Center for Disease Control and Prevention [CDC], 2014). Therefore, more aggressive and creative methods should be used to help patients reach their desired goals. This project attempted to demonstrate how MI could be used to promote weight loss. Although there was no statistical significance, the experimental group did have substantial weight loss; 10 out of 17 experimental participants lost an average of at least 1 BMI unit (3-5 lbs.), the mean pre-/post-BMI difference of 1.13 units. By comparison, the control group had a mean BMI loss of 0.78 of a unit. Further study is recommended to assess the effectiveness of MI for weight loss and the effects of indirect motivation on weight loss.
Lectin Properties of Synthetically Produced Glucuronate, Alginate, and Related Boronates
Authors:   ,   Andrews University, Angel Vanessa
Published: June 2023

In the nineteenth century, researchers discovered that some proteins had the ability to agglutinate red blood cells (Goldstein, 1980). These proteins were found mainly in the seeds of leguminous plants and were named phytohemagglutinins or hemagglutinins. Particular hemagglutinins were able to agglutinate red blood cells (RBCs) of a specific blood type. Now a days, these proteins are more widely known as Lectins. Lectins are proteinaceous macromolecules of nonimmune origin, capable of interacting with carbohydrates to form complexes (Goldstein, 1980). Lectins sources derive mainly from leguminous plants, animals, fruiting bodies of fungi, and bacteria. This research focuses on identifying the lectin activity and characteristics of certain synthetic compounds. Lectin activity was assessed by observing agglutination reactions of synthetic compounds and human red blood cells of a known human blood group and type in the ABO system. Lectins continue to be the focus of research due to their potential diverse applications specifically for blood grouping, mitogenic activity, and even stem cell transplantation.
Computational Difficulty and Invariants of the Snake Cube Puzzle
Authors:   ,   Andrews University, Negrea Adrian
Published: June 2023

The snake cube is a popular puzzle that has been analyzed for its computational difficulty and shown to be NP-complete. Conceiving of the puzzle as a Hamiltonian path in an n x n x n graph, we offer a novel mathematical analysis by considering invariants of the puzzle. This allows us to determine necessary conditions for a particular snake cube to be solvable and eliminate a large class of possible puzzles as unsolvable. In particular, we establish upper and lower bounds on the possible number of straight components in solvable snake cube puzzles.
Use of milk samples in epizootic surveillance of cattle diseases
Authors: Mishchenko A. V. , Gulyukin A. M. , Oganesyan A. S. , Mishchenko V. A. , Gulyukin M. I. , Lopunov S. V. , Zabolotnaya I. M.
Published: June 2023

Relevance. The analysis of the possibility of using milk as a non-invasive type of samples in the epizootological control of diseases of cattle is given. During pathogenesis, many etiologic agents cause breast lesions or are excreted together with milk, which makes milk an ideal sample for laboratory diagnostics of infectious diseases of cattle, since it is available in any quantity and its samples are easy to collect.

Methods. Conventional methods of document analysis were used.

Results. It is shown that milk samples can be used both at the individual and at the population level for early identification of infected herds, screening of infected herds and use to obtain evidence of the well-being of herds. The availability of commercial diagnostic test systems for detecting antibodies in milk to the causative agents of leukemia of cattle, viral diarrhea of cattle, Brucella abortus, Mycobacterium avium subspecies paratuberculosis, Fasciola hepatica, Q fever (Coxiella burnetii) makes available programs for the control and eradication of diseases in dairy herds and at the level of countries. The use of combined non-invasive milk samples makes it possible to combat slowly progressive and chronic cattle infections of dairy cattle (bovine leucosis, paratuberculosis, brucellosis), and exclude carrier animals from the production chain in real time, which indicates the feasibility of introducing this type of samples into veterinary practice in the Russian Federation.
The influence of inert fats on the processes of digestion and intensity of milking of highly productive cows
Authors: Golovin A. V. , Tsarev E. A.
Published: June 2023

Relevance. It is known that highly productive cows in the first third of lactation experience an increased need for energy. One of the effective ways to increase the energy saturation of diets is the use of protected fats in their feeding.

Methods. The effect of hydrogenated and fractionated fats (GC «EFKO», Russia) on the processes of rumen metabolism, the digestibility of dietary nutrients and the intensity of milking of highly productive cows, when used in the period from 21 to 120 days of lactation, was studied in an experiment conducted in an experimental farm «Klenovo-Chegodaevo» (Moscow) on three groups of dairy cows of the holsteinized black-and-white breed with a milk yield of 7000 kg of milk for the previous lactation, 10 animals each.

Results. In physiological studies, it was found that the feeding of protected fats did not have a negative effect on the processes of rumen metabolism and had a positive effect on the trend of better digestion of dietary nutrients by animals of I and II experimental groups compared to the control, with an increase in the digestibility of crude fat by 2.7–3.1 abs. % (p < 0.05). Accounting for milk productivity showed that the inclusion of inert fats in the diets of cows of the experimental groups in the amount of 300 g/head/day, in order to increase the concentration of metabolic energy from 10.7 to 11.0 MJ per 1 kg of dry matter, contributed to an increase in milk yield 4% fat content for 120 days of lactation by 8.1–9.4% (p < 0.05), compared with the control, feed costs, expressed in ME, decreased by 5.3%. At the same time, in the milk of cows fed fractionated fat, an increase in the mass fraction of palmitic acid by 2.29 abs. % (p < 0.05), compared with the control. In general, for 305 days of lactation, the gross milk yield of 4% fat in cows of the experimental groups exceeded the control by 6.2–7.3% (p ≥ 0.05), with a decrease in feed costs (ME) by 4.8%.
Technological properties of milk of cows with different proportion of blood in the Holstein breed
Authors: Gorelik A. S. , Rebezov M. B. , Gorelik O. V.
Published: June 2023

Relevance. The priority task for the agro-industrial complex of Russia is to provide the population of the country with high-grade products. One of these products is milk. It is not only a valuable food product, but also a raw material for the dairy industry, its use for the production of certain products is determined by its technological properties. The study of these properties in a new genetic formation of dairy cattle in the Middle Urals zone has both scientific and practical interest.

Results. As a result of the research, it was found that the milk obtained from cows with a Holstein breed genotype (75–91%) was the best in terms of the content of dry matter and its components. Cowʼs milk, regardless of genotype, is suitable for the production of highly processed products — canned milk and cheeses. According to all indicators, milk, with the exception of cows of the group with a genotype of 97% or more in terms of the ratio of protein and SOMO, is suitable for making cheese. Lower rates of suitability of milk for processing into Adyghe cheese were observed in milk from cows with a Holstein genotype of more than 91%. To improve the clot, the use of rennet was proposed, which made it possible to reduce the cost of calcium chloride and obtain a denser clot. The use of new technological solutions in the manufacture of Adyghe cheese with the use of protein coagulators makes it possible to increase the degree of use of fat and protein from cowʼs milk and reduce the cost of milk for its production.
Influence of probiotics on growth dynamics and blood parameters of Zaanen goats
Authors: Safina A. K. , Hoggui M. A. , Gainullina M. K. , Krupin E. O.
Published: June 2023

Relevance. In the prevention and treatment of gastrointestinal diseases in the rearing of young animals, the restoration of intestinal biocenosis with the use of probiotics — bacterial preparations from live microbial cultures is of great importance.

The purpose of the research is to study the effect of probiotic feed additives Klyuver Pro and BeneFIT Basic on growth dynamics, feed costs and blood parameters of Saanen goats.

Methods. The studies were carried out at LLC «Lukoz Saba» of the Sabinsky district of the Republic of Tatarstan. The object of the study is the kids of the Saanen breed at the age of seven days. Scientific and economic experience was carried out according to the method of analogues. The chemical composition and nutritional value of feed, the dynamics of changes in live weight, the morphological and biochemical parameters of the blood of goats were studied. Statistical data processing was carried out using Microsoft Excel. A difference of p ≥ 0.05 was considered significant.

Results. Probiotic feed additives Kluver Pro and BeneFIT Basic activate metabolic processes in the body of kids, increase the digestibility and assimilation of feed, which has a positive effect on the growth and development of animals, and reduce feed costs. The live weight of goats treated with probiotics increased (compared with the control) by 7.7% (p ≥ 0.05) and 3.6%. Feed costs decreased per 1 kg of live weight gain decreased by 13.6% and 10.1%.

In the blood of animals treated with probiotics, there was an increase in hematocrit, hemoglobin and erythrocytes. In animals of the second group, these indicators increased by 17.4%, 31.7 g/l (39.3%) (p ≥ 0.001) and 4.45 ˟ 1012/l (77.1%) (p ≥ 0.001), in animals the third group — respectively, by 7.5%, 7.7 g / l (9.5%) (p ≥ 0.001) and 1.63 ˟ 1012/l (28.2%), as well as a significant decrease in ESR — by 0, 37 mm/g and 0.18 mm/g (p ≥ 0.001), calcium content by 20% and 24.2% (p ≥ 0.05).
The results of studies of the influence of temperature and density on the stability of marshmallow
Authors: Dolmatova I. A. , Zaitseva T. N. , Kuznetsova E. A. , Issayeva K. S.
Published: June 2023

Relevance. The quality of products tends to be a core indicator of any enterprise activity defining its competitiveness within market conditions to a great extent. Production of confectionery creams avoiding usage of stabilizers, preservatives and trans fats is a promising direction being demanded by consumers. Stability of the whipped mass within production and storage processes depends on the dynamics of the confectionery foam destruction, which leads to degradation of whipped products form and volume. Stability and dimensional stability of foam systems become key indicators of food products quality reflecting their major structural and mechanical properties.

Methods. This article studies dependence of the stability (incl. dimensional stability) of cream marshmallow on temperature and density. Through experimental path authors show influence of molasses temperature set in line with recipe on the whipped cream density.

Results. Molasses temperature determines the temperature denaturation of egg whites, their bond and forms a stable structure. The study of cream marshmallow samples obtained from molasses with a density of 1.3 g/cm3, 0.9 g/cm3 and 0.7 g/cm3 established that lower density of molasses added in line with the recipe forms a stronger and more stable structure of cream marshmallow.
PENGARUH BRAND IMAGE, DISTRIBUSI, DAN PROMOSI TERHADAP KEPUTUSAN KONSUMEN MENGGUNAKAN JASA PENGIRIMAN J&T EXPRESS DI DROP POINT KRAKATAU MEDAN
Authors: Darwin  , Yayuk Yuliana
Published: June 2023

This study aims to examine the effect of brand image (X1), distribution (X2), and promotion (X3) on consumer decisions (Y) to use J&T Express delivery services at Drop Point Krakatau Medan. The data used is data using probability sampling method, with a total sample of 98 respondents. The analysis method of this research uses multiple linear regression. The classical assumption test used has met the specified criteria, the t-test (partial test) shows that the brand image, distribution and promotion variables have a positive and significant effect on consumer decisions because the tcount > ttable brand image is 10.727 > 1.664, the tcount > ttable distribution of 2.698 > 1.664 and the value of tcount > ttable promotion of 11.872 > 1.664. From the results of the f test (simultaneous test) the value of fcount > ftable is 61,691 > 3.09, then this shows that brand image, distribution and promotion together have a significant effect on consumer decisions to use J&T Express delivery services at Drop Point Krakatau Medan.
An interdisciplinary comparison between artistic and juridical phenomena
Authors: Moraes Gerson Leite de , Moraes Lídia Leite de
Published: June 2023

This article aims to analyze the interdisciplinarity between the artistic and legal phenomenon. Within this topic, the potentialization of Art and Law are exposed, since, together, they can present a tool that goes beyond artistic entertainment and legal dogmatics, therefore, conferences and analogies will be made between the studied objects. Through Art, some concepts will be addressed and conceptualized, they are: logopathic understanding and the “image-concept”, artistic themes that are linked with filmic language. The contextualization of both concepts takes place through the use of cinema in Varguista propaganda. At the end of the article, there is a resumption of the interdisciplinary analysis between artistic and legal phenomena under the bias of Aristotle’s Poetics, work responsible for exploring the representation of reality through two concepts that the philosopher called: Mimesis and Catharsis. Other authors from the field of Politics, Communication and Language will be mobilized to achieve the respective objective of the article.
ТЕОРЕТИЧНІ АСПЕКТИ ФОРМУВАННЯ СТРАТЕГІЇ СТАЛОГО РОЗВИТКУ
Authors: Ковальський Андрій
Published: June 2023

У статті досліджено теоретичні основи формування стратегій сталого розвитку, фактори та інституційні характеристики які впливають сталий розвиток підприємств, проаналізовано існуючі типології стратегій сталого ведення бізнесу, питання ефективності впровадження стратегій Сталого розвитку на конкретних підприємствах, соціальні та екологічні наслідки діяльності компанії. Доведено, що успішно реалізовані стратегії сталого розвитку є засобом створення економічної цінності для компанії, а також соціальної цінності, а пропозиції в документі проливають світло на можливості, якими повинна володіти фірма для успішного впровадження стратегій сталого розвитку.
СОЦІАЛЬНІ МЕРЕЖІ ЯК ЕФЕКТИВНЕ СЕРЕДОВИЩЕ КОМУНІКАЦІЇ В МОВНІЙ ПІДГОТОВЦІ ФАХІВЦІВ З ОБЛІКУ В ІНКЛЮЗИВНОМУ ЗАКЛАДІ ОСВІТИ
Authors: КУШНІР Людмила Анатоліївна , КУШНІР Тетяна Михайлівна
Published: June 2023

Вступ. Впровадження сучасних технологій, які забезпечують удосконалення навчально-виховного процесу, доступність та ефективність освіти, підготовку молодого покоління до життєдіяльності в інформаційному суспільстві, є одним із пріоритетних напрямів розвитку освіти України. Відтак останнім часом вища освіта почала освоювати різні стилі навчання з урахуванням світових технологій, зокрема відкрите навчання, дистанційне навчання, електронне навчання та соціальні мережі. З розвитком соціальних мереж виникає нагальна потреба імплеменцації їх у процес навчання, оскільки студенти в такий спосіб отримуватимуть соціальну підтримку інших людей як джерело самореалізації. Актуальність теми пояснюється підвищеною зацікавленістю до пошуку ефективних засобів навчання української мови та мовної комунікації в інклюзивних закладах освіти. Мета. Дослідження та виявлення можливостей використання соціальних мереж і всього їхнього інструментарію для навчання фахівців з обліку в інклюзивному закладі освіти; розробка завдань, які можна використовувати на заняттях із української мови, залучаючи соціальні мережі. Результати дослідження полягають у низці теоретико-методологічних напрацювань. У статті висвітлено вплив і обґрунтувано доцільність та ефективність використання соціальних мереж в інтенсифікації навчального процесу та підвищенні рівня володіння українською мовою в інклюзивному закладі освіти; представлено статистику використання соціальних мереж в Україні; описано особливості та потенційні можливості таких соціальних мереж як Facebook, YouTube, Telegram, Instagram, Twitter; доведено, що завдяки зазначеним мережам і навчальним додаткам вивчення нового матеріалу стає більш доступним, а сама інформація стає більш цікавою та різноманітною, що осучаснює комунікацію між викладачем і студентом. Окрім цього, увагу зосереджено на розробленні завдань, які можна використовувати на заняттях з української мови, залучаючи соціальні мережі. Використання соціальних мереж у викладанні української мови доводить його позитивну роль у формуванні ефективної інформаційної середовища для успішного спілкування між викладачем і групою студентів.
РЕЗИСТЕНТНІСТЬ ОРГАНІЗМУ ТЕЛЯТ ПІСЛЯ НАРОДЖЕННЯ ТА У ІМПРИНТИНГ-ПЕРІОДІ ЗАЛЕЖНО ВІД ФУНКЦІОНАЛЬНОГО СТАНУ
Authors: Коленченко Віктор Анатолійович
Published: June 2023

Резистентність організму новонароджених телят та у імпринтинг – періоді залежить від умов росту та розвитку плоду. Дослідження показників процесу гемоцитопоезу та резистентності організму телят після народження та у імпринтинг – період проводили у зразках крові відібраних із судин пуповини та яремної вени. Встановлено негативний вплив гіпоксії на процеси формування системи крові та імунітету в організмі плоду, які у новонароджених тварин проявляються порушенням гемоцитопоезу. У тварин, які народились з ознаками гіпоксії, порушенням процесу першого вдиху та дихання суттєво знижуються формування фагоцитарного профілю крові, знижується активність лейкоцитів, а відповідно і резистентність організму. Після народження у функціонально активних телят загальна кількість лейкоцитів у крові виявилась у 1,72 рази (p<0,01) менша, ніж у телят, що народилися з ознаками гіпоксії. Враховуючи той факт, що телята народжуються з більшою кількістю нейтрофілів у крові, а профіль крові у жуйних є лімфоцитарним впродовж періоду від народження до завершення імпринтинг – періоду ( перші 6 діб життя), тривалість циркуляції нейтрофілів у крові біля 5-6 діб у функціонально активних телят знижується. По завершенню імпринтинг – періоду у крові телят другої групи підвищився вміст нейтрофілів до 65,20±4,42%, що в 1,59 рази більше даного показника після народження. В той же час загальна кількість лімфоцитів у крові в кінці імпринтинг – періоду знижується в 2,55 рази (p<0,001), до 21 %. Активність лейкоцитарної ланки захисту організму супроводжується зниженням резистентності організму. Відсоток активних лейкоцитів в крові телят контрольної групи був в 2,81 рази більше, ніж у телят другої групи. Активність лейкоцитів дозволила знешкодити 24,42±1,96 х10 9 /л мікробних тіл у крові телят першої групи і лише 11,19±1,03 х10 9 /л ( в 2,18 раза менше) у тварин другої групи. Результати досліджень свідчать про негативний вплив гіпоксії на процеси гемоцитопоезу та резистентність організму телят у період після народження та в імпринтинг – період.
СУЧАСНІ АСПЕКТИ ФІНАНСОВОЇ СТІЙКОСТІ ГОСПОДАРЮЮЧИХ СУБ’ЄКТІВ В СИСТЕМІ АГРОБІЗНЕСУ УКРАЇНИ
Authors: Єфанов В.А.
Published: June 2023

У статті розглянуто теоретичні аспекти фінансової стійкості господарюючих суб’єктів в системі агробізнесу України. Охарактеризовано поняття фінансової стійкості суб’єкта господарювання в сучасних економічних умовах. Подана та охарактеризована структура фінансової стійкості суб’єкта господарювання. Встановлена сутність фінансового стану суб’єкта господарювання. В процесі дослідження визначено та структуровано фактори, що впливають на фінансову стійкість суб’єкта господарювання в аграрному секторі економіки. Встановлено вплив внутрішнього та зовнішнього середовища на фінансову стійкість суб’єкта господарювання. Визначено способи пом'якшення негативних наслідків від впливу зовнішніх факторів на фінансову стійкість суб’єкта господарювання. Визначена важлива роль управління фінансовими ризиками, які можуть виникати та впливати на фінансову стійкість суб’єкта господарювання. Розроблена загальна концепція формування системи управління ризиками на підприємствах агропромислового комплексу.
ОСОБЛИВОСТІ ФІНАНСОВОЇ СИСТЕМИ В ЕКОНОМІЧНИХ ПРОЦЕСАХ КРАЇНИ
Authors: Орел А.М. , Дяченко В.В.
Published: June 2023

Дана наукова стаття присвячена можливостям фінансової системи економічного розвитку в секторах економіки країни. Значною мірою це залежить від їх потенційного ресурсу, а саме природних ресурсів, виробничих потужностей, кваліфікованих кадрів. Складовою економічного потенціалу є забезпечення фінансовими ресурсами, задля збалансованої та ефективної галузевої фінансової системи. Для того, щоб використовувати фінансові важелі, що впливають на економічні, місцеві, регіональні та національні економічні регулятори, які повинні відстежувати та тримати на контролю фінансові потоки, фактори дефіциту та сфери концентрації фінансових потенційних ресурсів. В дослідженні проаналізовано вплив внутрішнього попиту на фінансові ресурси та запобігання «відпливу» фінансових ресурсів за межі галузі. В умовах економічного спаду та нестабільного світового розвитку в економіці питання активаційних ролей має важливі наслідки, а саме регламенту національної системи фінансового регулювання, задля економічного зростання. Зменшити вплив опору факторів, необхідно реалізувати стимул заходів фінансового регулювання, поки держава прагне створити належні умови для сталої інтенсифікації економічний розвиток. Підсумовуючи, відповідне збільшення рівня ефективності системи державного управління, який мінімізує економічні та інституційні ризики формування має значення довгострокової фінансової стратегії, яка сприятиме рівновазі та узгодженості очікуваних макроекономічних цілей.
УПРАВЛІННЯ ЯКІСТЮ ПОСЛУГ ЯК ВАЖЛИВИЙ ФАКТОР ПІДВИЩЕННЯ КОНКУРЕНТОСПРОМОЖНОСТІ ПІДПРИЄМСТВ ІНДУСТРІЇ ГОСТИННОСТІ
Authors: Дишкантюк О.В. , Коваленко Л.М.
Published: June 2023

Розглянуто поняття якості послуг та напрямів управління нею. Виявлено фактори впливу на задоволення вимог споживачів як ступінь якості продукції. Наведено підходи до оцінки ефективності діяльності підприємств індустрії гостинності. Відображено систему порівняльних показників рентабельності, що залучаються для об’єктивності оцінки діяльності підприємств індустрії гостинності. Поставлена мета дослідження щодо з’ясування особливостей управління якістю послуг як важливого фактору підвищення конкурентоспроможності підприємств індустрії гостинності була досягнена. В свою чергу, визначені завдання щодо проведення аналізу взаємозв'язку між задоволеністю споживачів та ефективністю діяльності підприємства та встановлення ступеня впливу задоволеності споживачів на результати діяльності підприємств індустрії гостинності, були виконані.
"No theory, no party": senza teoria non c'è cambiamento
Authors: Cubelli Roberto , Balboni Giulia
Published: June 2023

L'approccio "transdiagnostico" ai disturbi del neuro- sviluppo può favorire la ricerca e la comunicazione, ma è privo di teoria. Senza un modello teorico l'identificazione delle cause dei disturbi cognitivi e comportamentali, andando oltre la loro descrizione e categorizzazione, è impossibile. Un primo passo verso il cambiamento è il superamento della distinzione metodologica tra neuropsicologia dello sviluppo e neuropsicologia dell'adulto.
Un nuovo paradigma: impressioni sulla clinica contemporanea
Authors: Chieffo Daniela Pia Rosaria
Published: June 2023

Negli ultimi anni ed in particolare nell'attuale scenario post-pandemico, si evidenzia la necessità di un cambio di paradigma diagnostico per la psicologia evolutiva ed in specifico per i disturbi del neurosviluppo. Viene alla luce la necessità di definire i bisogni delle popolazioni cliniche anche in relazioni ad eventuali comorbidità in un'ottica biopsicosociale. In particolare è interessante notare che l'avvento delle nuove tecnologie ha avuto un impatto sullo sviluppo di alcune abilità cognitive specialmente nei nativi digitali. L'utilizzo di schermi virtuali, touchscreen e tecnologie digitali in maniera massiva va considerato come un elemento fondamentale nello sviluppo di nuovi profili cognitivi.
Elementos para la constitución de un sujeto intercultural en un orden neoliberal
Authors:   Universidad de Guanajuato, Martínez García Hugo
Published: June 2023

El objetivo principal de este artículo consiste en postular un modelo de sujeto intercultural que funja como contestación al sujeto neoliberal contemporáneo. Para tal fin se despliegan tres objetivos específicos: 1) se desarrolla el concepto de interculturalidad tomando como base el trabajo de León Olivé, y en función de ello se postula un modelo de sujeto intercultural; 2) se desarrollan las características que un orden social neoliberal despliega, así como la manera en que modela un tipo de sujeto particular que impide la articulación de un orden social ajeno a los valores del mercado; 3) se desarrollan los elementos que configuran al sujeto intercultural y se realizan algunas consideraciones para complementar el modelo con el análisis de dispositivos que fomenten su constitución.
Tensiones y problemas aparentes en el Tractatus
Authors:   Instituto de Investigaciones Filosóficas, Tomasini Bassols Alejandro
Published: June 2023

Mi objetivo en este ensayo es distinguir entre auténticos problemas que se le plantean al Tractatus Logico-Philosophicus y dificultades que son más aparentes que reales. Una limitación intrínseca a la filosofía del Tractatus es que su enfoque del lenguaje, la proposición y el pensamiento es puramente sintáctico y no basta para dar cuenta de diversos temas como el funcionamiento de los nombres, la cuantificación y la teoría del juicio. Sutilmente, Wittgenstein mismo se ve forzado a adentrarse en los dominios de la semántica. Con base en ello intenta mostrar que la teoría russelliana del juicio es errada, si bien la misma crítica se le puede aplicar a él mismo. Por último, recojo los importantes temas del silencio y los límites de la significatividad como ejemplos típicos de pseudo-dificultades que dejan al libro de Wittgenstein intacto.