bluuebunny/crossref_metadata_2025 huggingface dataset:
Paradigm shift in vertebral eosinophilic granuloma
Authors: Ozbek Muhammet Arif , Ipek Veyselkarani , Dinс Cem
Published: April 2023

Objective: Eosinophilic granuloma is the most common type of Langerhans cell histiocytosis. Vertebral bone involvement of eosinophilic granuloma is a rare disease. There are few studies in the literature on patients with vertebral bone involvement diagnosed with eosinophilic granuloma. There is still no clear protocol for the treatment of patients with vertebral involvement with eosinophilic granuloma. This article is a summary of the clinical follow-ups of our 6 cases diagnosed with spinal eosinophilic granuloma. We changed the chemotherapy protocol or extended the duration of chemotherapy in patients with progressive disease.Methods: In this study, there are six patients (4 male and 2 female) with vertebral involvement of eosinophilic granuloma in our hospital between September 2017 and August 2022. The clinical findings, radiological images, treatments and follow-up results of the patients were analyzed retrospectively.Results: In the follow-ups, a new vertebral bone involvement was observed in two patients and a femoral bone involvement was observed in another patient. One patient with neurological deficit underwent surgical treatment. Chemotherapy treatment was given to four patients with multiple bone involvement or recurrence. No recurrence was observed in three patients who started chemotherapy treatment after recurrence.Conclusions: Surgical treatment should be considered in patients with neurological deficits and spinal instability. According to the results of our study, patients with multiple bone or systemic involvement and no neurological deficit should receive chemotherapy treatment. We recommend changing the chemotherapy protocol or extending the chemotherapy duration in patients with progressive disease.
MAIN DIRECTIONS OF PROFESSIONAL TRAINING OF MILITARY HEALTH OFFICIAL
Authors: Новиков В.С. , Шелепов А.М. , Ефремов А.А.
Published: April 2023

В статье анализируются основные направления подготовки военного врача-организатора. Раскрыты и охарактеризованы его профессионально-важные качества, знания и умения. Сформулированы предложения для совершенствования Государственного образовательного стандарта специальности 56.04.11 в соответствии с новыми современными требованиями к работе руководящего состава медицинской службы Вооруженных Сил Российской Федерации.

We analyze the main directions of training military health officials. The key relevant qualities, knowledge and skills are revealed and described. We offer guidelines to improve the State Educational Standard of specialization 56.04.11 in accordance with new modern requirements to senior personnel of the Medical Service of the Armed Forces of the Russian Federation.
COMPETITIVENESS AS CRITERION FOR ASSESSING RUSSIAN STATE SYSTEM OF HIGHER EDUCATION
Authors: Кузьмин А.М.
Published: April 2023

Важнейшая цель высшего образования – подготовка высококвалифицированных кадров в соответствии с потребностями общества и государства, результатом которой является удовлетворение потребностей личности в интеллектуальном, культурном и нравственном развитии. Такую цель могут реализовать только вузы, обладающие высокой конкурентоспособностью.В статье проанализированы актуальные задачи, поставленные перед отечественной системой высшего образования задач Президентом РФ В.В. Путиным. Рассмотрены понятие, формы и факторы конкуренции в образовательной сфере, проанализирована практика конкуренции вузов в мировом образовательном пространстве. Сделан вывод о том, что развитие конкурентоспособности системы высшего образования в РФ требует усиленной финансовой поддержки и разработки новых подходов к оценке качества образования.

The priority of higher education is the training of highly skilled personnel in accordance with the needs of the society and state that results in meeting an individual’s needs in intellectual, cultural and moral development. The goal in question can be achieved only by highly competitive institutions of higher education. We analyze the relevant tasks facing the higher education in Russia that were determined by President V. Putin. We consider the concept of competition, its forms and factors in education and analyze the competition of universities in global educational environment. We make a conclusion that the development of the competitiveness of the system of higher education in the Russian Federation calls for financial support as well as new approaches to the assessment of education quality.
PROBLEMATIC ISSUES OF INFORMATION SECURITY AND POSSIBLE WAYS OF SOLUTION THEREOF
Authors: Костин Г.А. , Панин С.Н.
Published: April 2023

В статье рассматриваются основные проблемные вопросы защиты информации в современных информационных системах и технологиях, предлагаются возможные пути (направления) решения указанных проблемных вопросов на основе технических, программных средств и организационных мероприятий.

The article deals with main problematic issues of information security in modern information systems and technologies and suggests possible ways (directions) of addressing these problematic issues on the basis of technical, software and organizational arrangements.
EFFECT OF SUCCINATE-CONTAINING DRUGS ONNITRIC OXIDE LEVEL IN BLOOD PLASMA OF RATS
Authors: Паршукова О.И. , Вахнина Н.А. , Бойко Е.Р.
Published: April 2023

Одним из направлений современной физиологии является изучение адаптации клеток, тканей и органов к изменениям режима функционирования, в том числе при воздействии физических нагрузок разной интенсивности. Среди многочисленных биостимуляторов, используемых для оптимизации реакции организма на изменение средовых факторов, особое внимание заслуживает янтарная кислота (ЯК) и ее производные, эффекты которой крайне разнообразны. В исследовании показано, что прием сукцимера влияет на уровень оксида азота и его метаболитовв крови крыс во время выполнения физической нагрузки втесте плаванья «до отказа».

One of the directions of modern physiology is the study of the adaptation of cells, tissues and organs to changes in the mode of functioning, including the exposure to physical loads of different intensity. Succinic acid (SA) and its derivatives deserve special attentionamong numerous biostimulants used to optimize the body's response to changes in environmental factors, as their effects are extremely diverse. We demonstrate that Succimerum affects the level of nitric oxide and its metabolites in rats’ blood during physical activity in the test of swimming "till exhaustion".
ORGANIZATIONAL AND ECONOMIC ISSUES OF AIR CARRIER MANAGEMENT
Authors: Черняк Т.А.
Published: April 2023

В статье представлены результаты исследования, посвященного раскрытию особенностей управления авиаперевозчиком и выявлению современных проблем управления в рыночной среде РФ. Для целей обеспечения гибкости в управлении авиаперевозчиками выявлены факторы развития систем управления. Выделены организационно-экономические проблемы управления и очерчен типовой перечень организационных решений, позволяющих системе управления более гибко и оперативно реагировать на изменения во внешней и внутренней среде.

The article presents the results of a study dedicated to the disclosure of specific features of an air carrier management as well as to identification of current management challenges in the market environment of the Russian Federation. With a view towards ensuring flexibility in managing air carriers factors of management systems development have been identified. Furthermore organizational and economic management issues have been highlighted with a model list of organizational decisions being outlined to enable the management system become more flexible and responsive while addressing variety of changes in internal and external environment.
Basic principle from electrospray ionization to soft ionization mass spectrometry and development of ion source: part Ⅱ
Authors: Luo Jiehong
Published: April 2023

This paper continue talking about some questions in the experimental phenomenon and basic principle of soft ionization mass spectrometry, describe the forces between the charge and the analyte, ideal model of soft ionization technology, multi-charge and supercharging of proteins, mobility of gaseous ions in weak electric fields, the design of ion source and so on.
Understanding the catalytic active sites of crystalline CoSb2O6 for electrochemical chlorine evolution
Authors: Dong Heng , Shao Xiaohan , McBeath Sean , Tarpeh William , Hoffmann Michael
Published: April 2023

The chlorine evolution reaction (CER) is a key reaction in electrochemical oxidation (EO) water treatment. Conventional anodes based on platinum group metals (PGMs) can be prohibitively expensive, which hinders the further application of EO systems. Crystalline cobalt antimonate (CoSb2O6) was recently identified as a promising alternative to conventional anodes due to its high catalytic activity and stability in acidic media. However, its catalytic sites and reaction mechanism have not yet been elucidated. This study sheds light on the catalytic active sites in crystalline CoSb2O6 anodes by using scanning electrochemical microscopy (SECM) to compare the CER catalytic activities of a series of anode samples with different Sb/Co ratios. The results showed that Sb sites served as more active catalytic sites than the Co sites. The varied Sb/Co ratios were also linked with slightly different electronic states of each element, leading to different CER selectivity in chloride solutions. The high activity of Sb sites towards CER highlighted the significance of the electronic polarization that changed the oxidation states of Co and Sb.
Chemical insights into silica growth on nanoscale diamond using multimodal characterization and simulation
Authors: Sandoval Perla J. , Lopez Karen , Arreola Andres , Len Anida , Yamaguchi Pomaikaimaikalani , Kawamura Rina , Stokes Camron X. , Melendrez Cynthia , Simpson Davida , Lee Sang-Jun , Titus Charles , Altoe Virginia , Sainio Sami , Nordlund Dennis , Irwin Kent , Wolcott Abraham
Published: April 2023

Surface chemistry of materials that host quantum bits such as diamond are an important avenue of exploration as quantum computation and quantum sensing platforms mature. Interfacing diamond in general, and nanoscale diamond (ND) in particular with silica is a potential route to integrate the quantum bit into a photonic device, fiber optic, cells or tissues with flexible functionalization chemistry. While silica growth on ND cores has been used successfully for quantum sensing and biolabeling, the surface mechanism to initiate growth was unknown. This report describes the surface chemistry responsible for silica bond formation on diamond and uses X-ray absorption spectroscopy (XAS) to probe the diamond surface chemistry and its electronic structure with increasing silica thickness. A modified Stöber (Cigler) method was used to synthesize 2–35 nm thick shells of SiO2 onto carboxylic acid rich ND cores and the diamond features and surface structure were characterized by overlapping techniques including electron microscopy. Importantly, we discovered that SiO2 growth on carboxylated NDs eliminates the presence of carboxylic acids and that basic ethanolic solutions converts the ND surface to an alcohol-rich surface prior to silica growth. The data supports a mechanism that alcohols on the ND surface generate silyl-ether (ND-O-Si-(OH)3) bonds due to rehydroxylation by ammonium hydroxide in ethanol. Additionally, resonant inelastic X-ray scattering (RIXS) maps produced by the transition edge sensor supports the chemical analysis provided by XAS. The suppression of the diamond electronic structure as a function of SiO2 thickness was observed, and the Auger electron escape depth was modeled using the NIST database for the Simulation of Electron Spectra for Surface Analysis (SESSA) to support our experimental results. Researchers using high-pressure high temperature (HPHT) NDs or any alcohol-terminated material (metal oxides, oxidized silicon carbide or cubic-boron nitride) for quantum sensing applications may exploit these results to design new core-shell quantum sensors with base-catalyzed reactions and metal oxide precursors.
DockSurf: A molecular modeling software for the prediction of protein/surface adhesion.
Authors: Barbault Florent , Bremond Eric , Rey Julien , Tuffery Pierre , Maurel François
Published: April 2023

The elucidation of structural interfaces between proteins and inorganic surfaces is a crucial aspect of bionanotechnology development. Despite its significance, the interfacial structures between proteins and metallic surfaces have yet to be fully understood, and the lack of experimental investigation has impeded the development of many devices. To overcome this limitation, we suggest considering the generation of protein/surface structure as a molecular docking problem with a homogenous plan as the target. To this extent we propose a new software, DockSurf which aims to quickly propose reliable protein/surface structure. Our approach considers the conformational exploration with Euler's angles, which provide a cartography instead of a unique structure. Interaction energies were derived from QM computations for a set of small molecules that describe protein atom-types, and implemented in a DLVO potential for the consideration of large systems such as proteins. The validation of DockSurf software was conducted with molecular dynamics for corona proteins with gold surfaces and provided enthusiastic results. This software is implemented in the RPBS platform to facilitate widespread access to the scientific community.
Ring Opening of Aziridines by Pendant Silanols Allows for Stereospecific Preparations of 1’-Amino-Tetrahydrofurans
Authors: Sathyamoorthi Shyam , Nirpal Appasaheb , Nagamalla Someshwar , Mague Joel
Published: April 2023

We have developed a highly stereospecific cyclization of aziridine silanols into 1’-aminotetrahydrofurans. Our protocol of stirring substrate with 10 mol% of Sc(OTf)3 and 1 equivalent of NaHCO3 in CH2Cl2 is mild and compatible with a range of activating aziridine N-substituents and functional groups on the alkyl chains. In all cases examined, trans di-substituted aziridine silanols give products with an erythro configuration; conversely, cis di-substituted aziridine silanols give products with a threo configuration. While literature syntheses of 1’-amino-tetrahydrofurans exist, only one example, contemporaneous with our work, uses a similar cyclization for their construction. Control experiments demonstrate that, for this transformation, the silanol is not particularly privileged, and a variety of protecting groups on the alcohol are compatible with product formation.
Chemical Reaction Networks Explain Gas Evolution Mechanisms in Mg-Ion Batteries
Authors: Spotte-Smith Evan Walter Clark , Blau Samuel M. , Barter Daniel , Leon Noel J. , Hahn Nathan T. , Redkar Nikita S. , Zavadil Kevin R. , Liao Chen , Persson Kristin A.
Published: April 2023

Out-of-equilibrium electrochemical reaction mechanisms are notoriously difficult to characterize. However, such reactions are critical for a range of technological applications. For instance, in metal-ion batteries, spontaneous electrolyte degradation controls electrode passivation and battery cycle life. Here, to improve on our ability to elucidate electrochemical reactivity, we for the first time combine computational chemical reaction network (CRN) analysis based on density functional theory (DFT) and differential electrochemical mass spectroscopy (DEMS) to study gas evolution from a model Mg- ion battery electrolyte — magnesium bistriflimide (Mg(TFSI)2) dissolved in diglyme (G2). Automated CRN analysis allows for facile interpretation of DEMS data, revealing H2O, C2H4, and CH3OH as major products of G2 decomposition. These findings are further explained by identifying elementary mechanisms using DFT. While TFSI– is reactive at Mg electrodes, we find that it does not meaningfully contribute to gas evolution. The combined theoretical-experimental approach developed here provides a means to effectively predict electrolyte decomposition products and pathways when initially unknown.
Lipidic drug delivery systems: is the microbiome a cause for concern?
Authors: Caukwell Jonathan , Assenza Salvatore , Hassan Karl , Neilan Brett , Salvati Manni Livia , Fong Wye-Khay
Published: April 2023

The formulation of ‘smart’ therapeutics has sparked an explosion of interest in lipidic nanomaterials. In vitro and in vivo tests for therapeutic agents have traditionally been run in sterile environments, but many target areas for drug delivery such as the gastrointestinal (GI) tract and skin are home to thousands of microbial species. Here, we examine the behaviour of lipidic nanomaterials after exposure to representative strains of four bacterial species found in several human microbiomes. Small angle x-ray scattering (SAXS) measurements show that the nanostructure of monoolein cubic and inverse hexagonal phases are transformed, respectively, into inverse hexagonal and inverse micellar cubic phase upon exposure to a strain of live Staphylococcus aureus often present on skin. Further investigations support that these transitions are due to enzymatic hydrolysis of constituent lipids. The structural transformations induced by S. aureus are shown to take place within a timeframe relevant to the therapeutic application of these materials, and significantly reduced the rate of drug release from monoolein-based nanomaterials. Interestingly, the representative strains of bacteria investigated from the GI tract (E. coli, L. rhamnosus) and in disease states (P. aeruginosa) had no effect on liquid crystal structure. These findings are the first to demonstrate how the live human microbiome can trigger changes in the structure and consequent drug release properties of lipidic nanomaterials. The effect appears to be strain specific, and varies from patient to patient, body region to body region, and is anticipated to affect the bioapplication of monoglyceride-based formulations.
The Interrelation of Psychological Security of University Educational Environment and Psychological Well-Being of Its Subjects
Authors:   Irkutsk State University, Kedyarova E. A. , Chernetskaya N. I. ,   Irkutsk State University, Kondrashova N. S ,   Irkutsk State University, Litvinenko K. S. ,   Irkutsk State University, Shchukina E. G. ,   Transbaikal State University
Published: April 2023

The article presents the results of the correlation study of psychological security of university educational environment and psychological well-being of its subjects. The study has revealed the correlation between the concept of university educational environment and that of psychological wellbeing, as well as interrelation between them. The study has found that the higher psychological well-being of its subjects is the more favorable psychological climate is in their view and vice versa (p ≤ 0,01). Moreover, there is a correlation between satisfaction with educational environment and all components of psychological well-being of its subjects. It has been proved that the more secure a subject of educational environment feels in it the more psychologically unscathed he or she is, and conversely, the higher psychological well-being of a subject is the more secure he or she feels (p ≤ 0,01).
Dynamics of Identity of Adolescents with Different Character Accentuations
Authors:   Institute for the Development of Education of the Irkutsk Region, Kiseleva A. A. , Mironova E. I ,   Irkutsk State University, Osipenok O. A. ,   Irkutsk State University, Kuzmin M. Y. ,   Irkutsk State University
Published: April 2023

The article discusses the features of the dynamics of the identity of adolescents with different types of character accentuations. The authors suggest that the prevalence of certain accentuations of the character of adolescents have an impact on the formation of identity in general. Based on the results of empirical research, the authors come to the conclusion that character accentuations affect the dynamics of identity in different ways. For adolescents with a high severity of hyperthymic accentuation, a decrease in the manifestations of an identity crisis is more characteristic; persons with emotive, exalted and cyclothymic accentuations showed an increase in crisis manifestations of identity. The results obtained can be applied in the development and improvement of methods of psychological influence, to create individual programs of psychological support for adolescents with various manifestations of character accentuations.
Image contrast enhancement for preserving entropy and image visual features
Authors: Bataineh Bilal
Published: April 2023

Histogram equalization is essential for low-contrast enhancement in image processing. Several methods have been proposed; however, one of the most critical problems encountered by existing methods is their ability to preserve information in the enhanced image as the original. This research proposes an image enhancement method based on a histogram equalization approach that preserves the entropy and fine details similar to those of the original image. This is achieved through proposed probability density functions (PDFs) that preserve the small gray values of the usual PDF. The method consists of several steps. First, occurrences and clipped histograms are extracted according to the proposed thresholding. Then, they are equalized and used by a proposed transferring function to calculate the new pixel values in the enhanced image. The proposed method is compared with widely used methods such as Clahe, CS, HE, and GTSHE. Experiments using benchmark datasets and entropy, contrast, PSNR, and SSIM measurements are conducted to evaluate the performance. The results show that the proposed method is the only one that preserves the entropy of the enhanced image of the original image. In addition, it is efficient and reliable in enhancing image quality. This method preserves fine details and improves image quality, supporting computer vision and pattern recognition fields.
Çocukluk çağı ayak ağrısının nadir nedeni: Os trigonum sendromu
Authors: ALTINEL AÇOĞLU Esma , YÜCEL Zehra , ÇAĞLAR Gizem , UCAN Berna , ÖZTEK ÇELEBİ Fatma Zehra , AKÇABOY Meltem
Published: April 2023

Os trigonum, genellikle asemptomatik olan ve talusun posteriorunda yer alan aksesuar bir kemiktir. Yedi-on üç yaşları arasında kemikleşme merkezi olarak ortaya çıkar ve genellikle bir yıl içerisinde talus ile birleşir. Ancak bu birleşme nadiren olmaz ve semptomatik olduğunda ‘Os trigonum sendromu’ olarak tanımlanır. Os trigonum sendromu çocuklarda arka ayak ağrısı ile karakterize nadir görülen klinik bir durumdur. Ayağın plantar fleksiyonu ile birlikte zorlu aktiviteler yapan sporcularda ve balerinlerde daha sık görülür. Burada sağ ayak bileğinde ağrı ve şişlik şikayeti ile başvuran ve os trigonum sendromu tanısı alan adolesan bir hasta sunulmaktadır.
Sezaryen olan primipar kadınların gözünden anne olma süreci; Nitel çalışma
Authors: KETEN EDİS Elif
Published: April 2023

Amaç: Bu çalışmanın amacı sezaryen olan primipar kadınların anne olma sürecini nasıl deneyimlediklerini incelemektir. Yöntem: Bu araştırma nitel araştırma yöntemlerinden fenomenoloji tasarımındadır. Araştırma verileri yarı yapılandırılmış form kullanılarak yapılan derinlemesine görüşmelerle toplanmıştır. Araştırmaya sezaryen olan 27 primipar kadın katılmıştır. Araştırma verileri içerik analizi yapılarak değerlendirilmiştir. Bulgular: Verilerin analizi sonucunda üç tema yedi alt tema belirlenmiştir. Araştırmada; “Sezaryen nedenleri” “Sezaryenle doğum yapmaya yönelik düşünceler” “Sezaryenle anne olma deneyimleri” temaları belirlendi. Çalışmada kadınların büyük bir bölümü vajinal doğum yapmak istediklerini ve sezaryen oldukları için üzgün hissettiklerini ifade etti. Bununla birlikte kadınların tamamı sezaryen sonrası dönemi zor bir süreç olarak tanımladı. Kadınların sezaryen sonrası annelik rolüne yönelik en zorlandıkları konuların emzirme ve bebekleriyle ilgilenme olduğu belirlendi. Sonuç: Araştırma sonuçları primipar kadınların sezaryen sonrası zor bir süreç deneyimlediklerini ve desteğe gereksinimleri olduğunu gösterdi. Bu doğrultuda gebelik sürecinden itibaren kadınların ve ailelerinin doğum şekillerine yönelik bilgilendirilmeleri ve postpartum süreçte desteklenmeleri önem taşımaktadır.
Transformation of the social-economic and political values in Ukraine to the European Union values
Authors: Nosova O.
Published: April 2023

The article aims to analyze basic value approaches and define the main and decisive factors of values transformation. The research methods include descriptive analysis, institutional approach, and economic and statistical methods. The hypothesis of the study is to study how public perceptions have changed in extreme conditions (military conflict) towards European integration values. The broad scope of economic and sociological works reveals the necessity of a special analysis of the European integration and regional values adaptation in Ukraine and defines the problem for study, use, and dissemination of knowledge of the European Union values. The analysis of various value theories identifies the urgency and necessity of human behavior from the human value estimation study. We estimate how economic development depends on economic, political, and social values transformation and the overall indicators (market and democracy) reforms in Ukraine. We apply data from surveys to the comparing the population’s attitude toward European values since Ukrainian independence. The designation of core values allows formulating a strategy and intensifying a more sustainable strategy of political and social-economic development.
The banking sector of Ukraine in the space of influence of the VUCA environment on financial stability
Authors: Kostohryz V. , Zhezherun Y. , Korsun I.
Published: April 2023

Ukraine has been operating in a VUCA environment for quite a long period of time, which was significantly aggravated under the influence of the Covid-19 pandemic and the beginning of full-scale military operations on the territory of the country. A VUCA environment, as the antipode of stability, is characterized by chaos and unpredictability. In this article, financial stability of the banking sector is considered as its ability to effectively perform its functions and resist the effects of destructive factors of a VUCA environment. The essence and features of a VUCA environment manifestation have been examined in the article. The main challenges of the VUCA environment, which caused destructive changes in macroeconomic indicators and the main indicators of the functioning of the banking sector, have been identified, namely: the impact of the global financial crisis of 2008-2009; destabilization of the political situation, the conduct of the anti-terrorist operation in the east of Ukraine, the annexation of Crimea (since 2014); the impact of the Covid-19 pandemic (since 2020); a full-scale military invasion of Russia into the territory of Ukraine (since February 24, 2022). The country’s economy as a whole and the banking sector in particular have suffered the greatest losses during the studied period precisely as a result of the full-scale military invasion. In response to the challenges of the VUCA environment, it became necessary to develop concepts for countering destructive influences. The strategy of behavior in the VUCA environment is aimed at adaptive behavior, meaningful risk, and active implementation of innovations in the business model. Among the technologies that change business models of banks, acting as tools of digital transformation, providing new approaches to customer service and organization of internal business processes in banks, there are: artificial intelligence, big data, blockchain, biometrics, application programming interfaces, etc.
Ecologization of production as an innovative direction for the development of domestic business entities
Authors: Butko N.
Published: April 2023

The necessity of compliance with environmental standards in the process of production activities of agricultural business entities in order to ensure their successful functioning is substantiated. It has been studied that the approach to the production of environmental products, is innovative due to the application of measures that cause minimal damage to the environment. Ecologization of agricultural production involves restoring the agro-resource potential of land, preserving the environment and growing quality and safe food. It was found out that ecologization of production in the agricultural sector is formalized in the concept of organic production, which embodies the idea of a healthy lifestyle and nutrition. It is highlighted that organic production ensures the manufacture and sale of organic products that are obtained as a result of certified production within the legally established procedures. It is substantiated that ecologically oriented management is an important direction of innovative development of the agricultural sector enterprises and it is closely related to the environmental aspects of the use of their lands. The study of the indicators of the development of organic production in Ukraine showed the distribution of operators of certified subjects of the organic market of the country by their number and the total area of agricultural land in 2021. The factors that constrain the development of organic production of domestic business entities are shown. It is noted that the production of organic products brings much higher profits to agricultural producers compared to the traditional one and the reasons for the profitability of such ecological systems are described. To ensure the effective ecologization of production, domestic business entities should search for innovative forms of economic and organizational cooperation among themselves. Such interaction will be a priority area for innovative development of agricultural sector enterprises, which will allow to realize ecological balance in agro-ecosystems. The aspects of stimulating the ecologization of production within enterprises that have chosen an innovative way of development are described. These are organizational, managerial, environmental, geographical and economic and legal features of the development of ecologically-oriented business entities.
Analysis of the current state of national mobile games markets
Authors: Bobrov V.
Published: April 2023

The work includes a general analysis of the global market of mobile games and a comparative analysis of the largest national markets of mobile games. The key indicators of the mobile games market in different countries of the world were chosen as the object of the study. Since the beginning of the 2010s, the market has been growing steadily by 10% every year and has trends for further development. Such a process has many prerequisites: the development of mobile technologies, the improvement of the standard of living of the population, the increase of free time and the popularization of interactive entertainment. The work offers a brief description of the formation of the mobile game market and its advantages among competitors, a full description of the global mobile game market and its segregation into the largest centers and promising markets. The characteristics of the largest world markets: China, the USA, Japan, South Korea, the reasons for their success and current statistics are given. The most promising world regions are singled out: Europe, Africa and South America, and the main challenges for each of them are given. The findings provide numerical figures for developed and developing regions and the reasons why this difference exists. The graphs of the number of mobile game applications in the App Store, the number of players by region of the world, the dynamics of the market volume and the forecast for China and the USA were constructed and analyzed. Comparative tables and separated data for each of the considered regions were built. The results of the study showed that the main global markets have a common trend of growth in both the number of players and the revenue per player. In addition, the main challenge of the future can be considered approaching the maximum number of players and the limitation of their free time. Another important trend is the constant rapid development of technologies, which makes mobile games a real competitor for computer and console counterparts. The results of the research can be used to make decisions for mobile companies about entering new markets, as well as to analyze the key development trends for the coming years for the entertainment industry as a whole.
The interrelationship between unemployment and indicators of socio-economic development
Authors: Litvina M.
Published: April 2023

Unemployment is a complex socio-economic phenomenon in which a part of the economically active population does not have a job or income. Unemployment has negative socio-economic consequences, among which the main ones are: the growth of marginal population groups, the criminalization of society, the psychological depression of the unemployed is expressed by suicide, alcoholism, drug addiction, and as a result, a decrease in natural population growth and life expectancy. Such a complex and multifaceted phenomenon as unemployment depends not only on the economic indicators of the countries' development, but also on the indicators of the social development of societies. Therefore, the purpose of the work will be to identify the interrelationships of unemployment and socio-economic indicators of the countries' development. For the analysis, data was obtained from the open databases of 2 organizations "The World Bank" and "The Heritage Foundation". Based on this, 162 countries and 84 indicators of socio-economic development were selected. The data was prepared for modeling, the optimal number of clusters was determined. As a result of simulation, 9 different clusters were obtained. During the analysis of clustering results, it was found that countries with a higher index of economic freedom usually have a lower unemployment rate than countries with a lower level of economic freedom. The indicator of economic freedom is only a reflection of state policy at various levels: citizens' rights, judicial efficiency, tax policy, freedom of labor, business and investment, etc. Therefore, in order to reduce the unemployment rate in the country, it is necessary to introduce laws to prevent the improvement of judicial efficiency. It was also found that countries with a higher ratio of GDP per capita have a lower level of unemployment. A lower level of unemployment in countries is also observed with a lower percentage of the self-employed population. The self-employed population has less and less room for work due to new technologies and a very high entry threshold for many activities, such as production, distribution, etc. Positive migration is also interconnected with a decrease in unemployment. A lower unemployment rate is followed by lower loan rates. Lower interest rates on bank loans stimulate business to expand and develop. Along with the decrease in the percentage of the employed population in agriculture, the decrease in the percentage of unemployment in the country is followed. Rather, it is related to a more general and complex process of development of the industrial system of society and scientific and technical development. The presented results can be the basis for further research. For example, developing a factor analysis or building a regression or multifactor model for the countries of the same cluster.
Assessment of comorbid profile, quality of life and social functioning in patients with schizophrenia and schizotypal disorders
Authors: Romash I.R.
Published: April 2023

One of the most common mental illnesses is schizophrenia and schizotypal disorders. According to the literature data, mortality among patients with schizophrenia is 1.5-2 times higher than among the general population. Patients with schizophrenia have a higher prevalence of cardiovascular disease, obesity, diabetes, osteoporosis in comparison with the general population. Such comorbid somatic diseases in the case of schizophrenia have a more acute course, a significant impact on the course of the underlying disease, the development of complications, decrease in quality of life and social functioning. The aim of the study was to study the presence and features of comorbidity, its impact on the quality of life and social functioning of patients with schizophrenia and schizotypal disorders. 100 patients were included in the study. They were divided into two groups: experimental (Group I) with schizophrenia and comparison (Group II), with other schizophrenic diseases, such as schizoaffective and schizotypal disorder. All patients were scaled according to the following methods: The Cumulative Illness Rating Scale (CIRS), Clinical Global Impression – Severity Scale (CGI-S), The Personal Social Performance Scale (PSP), CGI-S, and a short form of the questionnaire Medical Outcomes Study 36-Item Short-Form Health Status (SF-36). Charlson Index was also calculated for all patients included in the study. Due to CIRS, we detected undiagnosed comorbidity that aggravated the course of the underlying disease: 38% in Group I and 26% in Group II. The most common components in the structure of comorbidity in the patients with schizophrenia were diabetes mellitus, musculoskeletal diseases, cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD). Patients with schizotypal disorders were more often diagnosed with peripheral vascular diseases, chronic lung diseases, chronic kidney diseases, and upper gastrointestinal tract disorders. A com­pre­hensive approach to be important in the treatment of such patients. The nature and extent of comorbidity should be definitely taken into account. This will promote the compliance and improve the indicators in the examined category of patients.
Comprehensive analysis of pain syndrome in patients with rheumatoid arthritis
Authors: Grygus I.M. , Nogas A.O.
Published: April 2023

Rheumatoid arthritis is a chronic systemic disease of connective tissue of immune genesis and unknown etiology. In the developed countries of the world, about 1 in 100 people suffer from rheumatoid arthritis, while in Ukraine the occurrence of the disease is 340 cases per 100,000 adult population. Chronic pain syndrome and limitation of joint functions significantly reduce the life quality of patients. At this stage, along with drug therapy, physical rehabilitation / therapy plays an important role in the restorative treatment of patients with rheumatoid arthritis. The purpose of the study is a comprehensive assessment of the main indicators of pain syndrome and morning stiffness of joints in patients with rheumatoid arthritis. 216 patients with rheumatoid arthritis were examined: 178 (82%) of them were women, 38 (18%) were men. The age of the patients is from 25 to 59 (average age is 46±0,24). The diagnosis was established on the basis of the ACR/EULAR 2010 criteria and in accordance with the Order of the Ministry of Health of Ukraine No. 263 dated November 04, 2014. A comprehensive analysis of the pain syndrome in patients with rheumatoid arthritis was carried out. Pain and severity of morning stiffness in the joints were determined using Huskisson’s visual analog scale (VAS, 100 mm). Statistical analysis was performed on the basis of the statistical analysis Statistica 10 (Serial Number: STA999K347150-W) and MEDCALC®. It was found that pain of low intensity was observed in 62 (28,7%), pain of medium intensity – in 120 (55,6%), and maximum intensity pain was experienced by 34 (15,7%) patients. It was found that in women with rheumatoid arthritis of radiological stage I, the average morning stiffness index according to VAS (100 mm) is 46,1±7,3, in men – 45,3±4,8; in women of radiological stage II, the average indicator is 52,6±7,9, in men – 50,3±6,1; in women of radiological stage III, the average indicator is 66,8±5,9, in men – 63,6±1,7. The analysis of the indicators showed that the severity of morning stiffness is more pronounced in women of all radiological stages than in men. All the above determines an urgent need to develop and implement in practice the concept of physical therapy for patients with rheumatoid arthritis in order to reduce the pain syndrome, severity of rheumatoid arthritis, eliminate morning stiffness, improve the functional condition and restore the motor functions of the joints, improve the health and quality of life of patients.
Роль монетарної політики держави у період постконфліктного відновлення економіки
Authors: Бульчак Сергій Іванович
Published: April 2023

У статті досліджено роль монетарної політики у економіці держави як одного із основних інструментів підтримки її фінансового потенціалу як в умовах воєнного конфлікту, так і в умовах післяконфліктного відновлення. Методологічною основою є загальні та спеціальні методи наукового дослідження, у тому числі методи теоретичного узагальнення, синтезу та аналізу, моделювання, порівняння та інші. Як основна інформаційна база були використані дані ресурсу Wolrd bank Open Data, дані Національного банку України та Державної служби статистики України. Вирішення проблеми функціонування економіки держави під час воєнних дій та у період післявоєнного відновлення є актуальним науковим та практичним завданням. Одним із основних важелів забезпечення сталості розвитку та балансу економіки, її виведення зі стану «турбулентності» є монетарна політика у поєднанні із гнучкими фіскальними інструментами. Навіть із урахуванням усіх допущених історичних помилок та проведених війн людство досі не навчилося повністю попереджати, запобігати та врегульовувати воєнні конфлікти, та й сам характер таких зіткнень став іншим, більш залежним від фінансового потенціалу держави, її інформаційного та інших впливів як всередині держави, так і за її межами. Саме тому здатність держави мобілізувати фінансові ресурси, підтримувати власну грошову одиницю, кредитувати економіку є одними із ключових факторів досягнення зі свого боку позитивного результату у конфлікті та у подальшому постконфліктному відновленні.
Теоретичні аспекти фінансової політики банківської установи
Authors: Гладищук Яна Андріївна
Published: April 2023

Статтю присвячено дослідженню теоретичних засад фінансової політики, її особливостей на різних рівнях фінансової системи. Окреслено прогалини в наукових дослідженнях під час аналізу фінансової політики (відсутнє однозначне тлумачення поняття «фінансової політики» та її складових; існують проблеми структуризації фінансової політики через неповну її класифікацію та відсутність упорядкованості). Виявлено потребу у дослідженні фінансової політики з огляду на її важливість на мікро- та макрорівні економіки. Проведено термінологічний розбір поняття «фінансової політики», висновком якого стало ствердження, що це поняття різноспрямоване, при цьому зосереджується увага на двох напрямах трактування фінансової політики – фінансової політики держави і фінансової політики підприємства. Запропоновано власне тлумачення поняття «фінансової політики» як системи. Обґрунтовано вибір системного підходу до визначення сутності фінансової політики. Досліджено підходи вчених до структуризації фінансової політики. Виокремлено спільні класифікаційні ознаки фінансової політики держави та суб’єкта господарювання (за складовими, терміном дії, завданнями), запропоновано нові класифікаційні ознаки фінансової політики суб’єкта господарювання з огляду на взаємозв’язок із поняттям «фінансової політики держави» (відповідно до джерел формування, способу взаємодії з державою, напрямами реалізації) та окремо доповнено класифікацію фінансової політики суб’єкта господарювання (відповідно до видів діяльності та форми власності). Визначено підходи до трактування сутності банківської установи. На основі проведеного дослідження запропоновано тлумачення поняття «фінансова політика банківської установи».
Управління якістю продукції підприємства: теоретичні аспекти та принципи застосування
Authors: Денисюк Олена Григорівна , Майданович Валентин В'ячеславович
Published: April 2023

Ефективне провадження управління якістю продукції підприємства в умовах світової глобалізації, постковідного відновлення економіки, воєнного стану та післявоєнної відбудови країни є визначальним фактором виживання на ринку, втримання лідерських позицій у галузі та забезпечення високого рівня конкурентоспроможності. Представлено публікаційну активність науковців за досліджуваною тематикою, зокрема у наукометричній базі Web of Science Core Collection. Окреслено теоретичні аспекти управління якістю продукції підприємств: еволюція та сутність дефініції «якість», зміст системи управління якістю (СУЯ), понятійний апарат відповідно до стандарту ISO 9000:2015 «Системи управління якістю: основні положення та словник термінів». Понятійний апарат узагальнено через відповідні групи термінів. У статті презентовано діяльність та активність Міжнародної організації зі стандартизації щодо розробки та популяризації впровадження механізмів управління якістю на підставі міжнародних стандартів, представлено узагальнену статистику діяльності в розрізі дійсних сертифікатів та підприємств за видами економічної діяльності, що їх отримують. Приділено ґрунтовну увагу принципам управління якістю: здійснено їх характеристику та узагальнено ключові переваги провадження діяльності підприємства з їх використанням. Представлено політичний, соціальний, економічний, науково-технічний та організаційний аспекти управління якістю продукції підприємства. Також визначено перспективи подальших досліджень за цією темою.
Розвиток світової економіки за умов зростання ризиків глобальної рецесії
Authors: Колобердянко Іван Іванович , Краснощок Ярослав Валерійович
Published: April 2023

Розглядаючи питання рецесії, можна прийти до висновку, що це поняття виникає послідовно та спричинене багатьма факторами. Наразі виникла дуже велика суперечка між багатьма науковцями, щодо ймовірності виникнення глобальної рецесії в усьому світі. Цьому передує дуже багато факторів, головним з яких є тероризм росії проти України. Стаття присвячена дослідженню понять «економічний цикл», «рецесія» та причини її виникнення. Причини, що можуть спричинити сучасну глобальну рецесію, серед яких війна росії проти України, рішення ОПЕК+, що виражається в падінні цін на нафту, а також деградація трьох найбільших економік світу. Проаналізовано вплив російської агресії на світову економіку. Досліджено коливання цін на нафту та особливості прийнятих рішень організації країн-експортерів нафти. Розглянуто три найбільші економіки світу США, ЄС та Китай, їх розвиток на сучасному етапі, рівень інфляції та їх реакцію на можливу рецесію, причини, які передують виникненню рецесії. Зроблено висновки щодо загрози рецесії для України, серед яких падіння цін на сировину, зменшення фінансової допомоги від інших країн та іноземних інвестицій. Аналізуючи ймовірність настання рецесії, не можна отримати 100 % результат, але за оцінкою навіть при її настанні вона буде досить недовгою і майже непомітною для населення. Якщо розглядати українську економіку, то вплив від рецесії буде значно меншим, ніж від російського вторгнення.