bluuebunny/crossref_metadata_2025 huggingface dataset:
A mini-review on anaerobic digestion of Indonesian macroalgae biomass: present scenario and future scope
Authors: Elviliana Elviliana , Suhartini Sri , Hidayat Nur , Oechsner Hans
Published: January 2023

Macroalgae as the marine renewable biomass has great potential for production of bioenergy and bioproduct with integrated biorefinery concept. However, high lignin content may hinder the valorization. Same conditions applied for the macroalgae in Indonesia which has the great opportunity to explore more in the bioenergy field. This study aimed to investigate potential application of macroalgae as substrates for bioenergy production, specifically with anaerobic digestion (AD) technology. Anaerobic digestion as the one of the ways to transform macroalgae into biogas. This review analyses the latest study’s results from the view of composition, degradation, and the biorefining pathways. The biomass is constructed from lignocellulose compounds and have thick cell wall that be the main drawbacks for the biochemical conversion technology. Various enhancement pathways have been studied i.e., pretreatment methods to enhance the accessibility for microorganisms, reduce the outer cell wall thickness, and co-digestion with addition of other substrates to balancing the nutrition and providing the stable condition for AD system. In term to have more feasibility from economic view, the strategy is put in the biorefinery concept to have more valuable-added products. The decrement of energy input, higher of energy output and yield of outcome along with some products being produced are expected to gain from the proposed ways. Those information will provide new research directions and solutions for converting Indonesia marine macroalgae using AD technology.
The potential of spiced tea for health
Authors: Bekti Sunarharum Wenny , Yusa Ali Dego , Hasna Tanalyna , Pradichaputri Azzahramidha , Nathaniela Sabatudung Adnel , Eka Nurizza Nadyah , Ibnu Shidqi Farras Muhamad , Aurora Kartika Annisa
Published: January 2023

Tea (Camellia sinensis) is one of the most important commodities in the world, including in Indonesia. Tea products contain polyphenols, an antioxidant beneficial for health. Nowadays, tea product diversification has gain market and increased consumer acceptance due to its functional benefits besides flavour. The use of spices in tea is widely applied not only to add flavour, but also to increase its functional value. Various bioactive components contained in spices can be used as fragrances, flavour enhancers, preservatives, and natural colouring. This review explores the potential benefit of adding spices into tea (Camellia sinensis) to enrich previous studies on tea and to support development of Camellia sinensis-based tea in Indonesia.
PENGARUH SUHU TERHADAP DAYA KEMBANG, KELARUTAN, DAN KAPASITAS PENGIKATAN AIR PADA PATI UBI JALAR TERMODIFIKASI ULTRASONIK
Authors: Maria Ulfa Grace , Nopriyani Irma , Fathuroya Vivien , Dwi Rukmi Putri Widya , Fibrianto Kiki , Bambang Widjanarko Simon
Published: January 2023

Gelombang ultrasonik dapat dimanfaatkan untuk mengubah sifat fisik dan kimia pati ubi jalar. Pati yang telah dimodifikasi menggunakan gelombang ultrasonik dengan rentang suhu 35-60 °C memiliki peningkatan sifat fisik dibandingkan pati ubi jalar alami. Daya kembang, kelarutan, dan kapasitas pengikatan air merupakan beberapa parameter penting yang menentukan sifat fungsional pati modifikasi. Tujuan penelitian ini adalah untuk mengetahui pengaruh suhu terhadap daya kembang, kelarutan, dan kapasitas pengikatan air pati ubi jalar yang telah dimodifikasi. Hasil analisis morfologi pati menunjukan munculnya struktur berpori pada pati ubi jalar termodifikasi, serta adanya perubahan intensitas serapan IR. Selain itu, modifikasi pati ubi jalar menggunakan gelombang ultrasonik mampu meningkatkan daya kembang, kelarutan, dan kapasitas pengikatan air pati hingga titik tertentu. Akhirnya, diketahui suhu 55 °C memberikan hasil terbaik pada respon yang diamati.
Placenta accreta spectrum. Current diagnostic issues
Authors: Volkov A. E. , Rymashevskiy M. A. , Andrusenko I. V.
Published: January 2023

In this review of the literature, the issues of diagnosis of abnormal attachment (ingrowth) of the placenta (PAS) are considered: ultrasound scanning (ultrasound), magnetic resonance imaging (MRI), the study of serum markers of the anomaly. A systematic literature search was conducted on the databases PudMed, Scopus and others. The issues of the evolution of views on the causes of this anomaly and its classifications are also discussed. It is noted that currently the main method of diagnosis of placenta accreta is ultrasound. Two-dimensional grayscale scanning in combination with color Doppler mapping (CDK) and three-dimensional echography with the option of energy Doppler is recommended. However, echography remains an absolutely "operator dependent" method, therefore, largely subjective, determined by the experience of a specialist in detecting this pathology with an instrument. MRI is recommended as a tool for assessing the depth of invasion in case of suspected placenta percreta and in the diagnosis of complex cases (placenta previa along the posterior wall of the uterus). Ultrasound and MRI have a very high diagnostic potential. It is generally considered that ultrasound is an inexpensive, widely available imaging method, recommended as a priority in the diagnosis of PAS. MRI does not play a primary role in the diagnosis of PAS, but it can be indispensable for detailing the topography of areas that are difficult to assess with ultrasound.
Evaluation of treatment results in patients after surgical hemostasis using CT-angiography
Authors: Kantsurova M. R. , Rymashevsky A. N. , Sapronova N. G. , Babaev M. V. , Sapronov R. S.
Published: January 2023

Objective: to evaluate the results of treatment of patients after undergoing surgical hemostasis in obstetric hypotonic bleeding. Materials and methods: the 31 patients were examined, whose delivery was complicated by hypotonic uterine bleeding, and as a result, surgical hemostasis was performed in the amount of ligation of the ovarian and internal iliac artery. Anthropometric data were analyzed, as well as the dynamics of the results of laboratory and instrumental research methods before and after surgery. In the late postoperative period, the results of helical computed tomography (CT) under angiography conditions were evaluated in the period from 6 months to 5 years. Statistical processing was carried out using the IBM SPSS Statistics 25 program. Results: the age, anamnestic data, anatomical and physiological parameters of patients, terms of delivery and their outcome did not become predictors of developed hypotonic bleeding. Early postpartum bleeding was determined in 93,5% of cases. Extirpation of the uterus was performed in 9,7% of cases. The median blood loss was 1200,0 ml, blood loss of 45-50% of the BCC was determined in 19,4%, 35–45% of the BCC was also in 19,4%. The reduced level of erythrocytes persisted until the moment of discharge, and the reduced hemoglobin after the operation tended to increase. In the course of CT, in 100% of cases, defects in the contrasting of the internal iliac artery on both sides were determined. Collateral circulation was also developed in 100,0% of cases, despite the type of defect in the internal iliac artery. Conclusions: ligation of the ovarian and internal iliac artery is a reliable method of surgical hemostasis, which allows saving the uterus in 90,3% of cases. In the late postoperative period, all patients developed various degrees of arterial patency in the ligation zone, and collateral circulation developed on both sides.
Possibilities of predicting purulent-inflammatory complications after cesarean section
Authors: Kutsenko I. I. , Borovikov I. O. , Galustyan M. V. , Magay A. S. , Borovikova O. I.
Published: January 2023

Objective: identify the main risk factors in the development of purulent-inflammatory complications after cesarean section. Materials and methods: puerperal women after cesarean section (n = 90): 24 patients with a complication of puerperia in the form of endometritis (group I), 16 — with the insolvency of the suture on the uterus (group II) and 50 — with a physiologically occurring postoperative period (group (III) of control). An analysis of anamnestic, clinical and laboratory studies of puerperal women after abdominal delivery with a complicated postoperative period was carried out. With the help of logistic regression with the construction of an ROC-curve, a rank correlation analysis of the influence of adverse factors with the calculation of diagnostic coefficients (DC) was performed. Results: based on the assessment of the identified main clinical-anamnestic and laboratory predictors, using mathematical modeling methods, a scale for predicting the risk of purulent-inflammatory complications in early puerperia after abdominal delivery has been developed. Conclusion: prognostic mathematical scale for assessing the risk of purulent-inflammatory complications in puerperal women after abdominal delivery makes it possible to identify the main predictors of infectious diseases in these patients, which contributes to their timely prevention and, thereby, reducing the frequency of severe forms of postpartum infection.
Enhancement of Fischer-Tropsch Synthesis by Periodical Draining of the Wax-Filled Pores of a Cobalt Catalyst by Hydrogenolysis
Authors: Unglaub Carsten , Tiessen Johannes , Jess Andreas
Published: January 2023

Fischer-Tropsch reactors operated in a steady state suffer from a low pore effectiveness factor and a high methane selectivity caused by internal mass transfer limitations due to the accumulation of long-chain hydrocarbons inside the catalyst pores. Therefore, an alternating process switching between Fischer-Tropsch synthesis (FTS) and drainage of the pores by hydrogenolysis is proposed. The periodical cracking of the accumulated waxes within the (partially) filled pores, realized by a switch from syngas (H2, CO) to pure hydrogen, results in a higher overall catalyst productivity and a more favorable product distribution. The influence of temperature and time of FTS on drainage time and product distribution was experimentally investigated at typical temperatures of FT fixed bed processes in a range of 210 to 240°C. Alternating drainage of the pores by hydrogenolysis at a hydrogen partial pressure of just 1 bar leads to an improvement of the rate of CO conversion by up to 90% (240°C, 2 h FTS) and an improvement of even 120% concerning the rate of production of non-methane hydrocarbons (240°C, 2 h FTS).
Brain Imaging Studies Using Deep Neural Networks in the Detection of Alzheimer's Disease
Authors: Battineni Gopi , Hossain Mohammad Amran , Chintalapudi Nalini , Nittari Giulio , Ruocco Ciro , Traini Enea , Amenta Francesco
Published: January 2023

The increasing incidence of adult-onset dementia disorders and primarily Alzheimer’s disease (AD) among the aging population around the world is increasing the social and economic burden on society and healthcare systems. This paper presents three neural networking algorithms: MobileNet, Artificial Neural Networks (ANN), and DenseNet for AD classification based on MRI imaging data. The results of each model were compared in terms of performance metrics such as accuracy, true positive rate, and receiver operating curve values. Results mentioned that MNet classified AD progression with 95.41% of accuracy. Early detection and appropriate interventions, primarily on modifiable risk factors of AD, can delay the progression of cognitive impairment and other symptoms that represent a main trait of the disease.
Efficacy of Digital Therapeutics based interventions on quality of life and symptom burden in Lung Cancer patients- A feasibility study (Preprint)
Authors: shah Abhishek , Damse Sneha , Thiyagarajah premalatha , Shah Rushit
Published: January 2023

BACKGROUND

Lung cancer contributes to mortality as well as morbidity. The physical pain and symptoms , along with fear of disease related stigma can be emotionally burdening. Emotional problems are vital consideration and need to be addressed through Emotional wellbeing counseling interventions. Digital Therapeutics (DTx) is one such approach which has a potential role in addressing these problems providing 24/7 access to tools and resources at patient’s fingertips to help them better manage their disease in-between medical appointments.

OBJECTIVE

To evaluate the efficacy of a digital therapeutics based patient support intervention on symptom burden, Quality of life and emotional wellbeing of patients with Lung cancer.

METHODS

This was a feasibility trial (Pilot study) .This trial consisted of a patient support program which included CBT interventions that were done remotely through Wellthy Care digital therapeutics platform. The present trial included 30 users who were diagnosed with Lung Cancer (NSCLC and SCLC) on the Wellthy DTx platform. FACT-LCS , Wellthy Health Related Quality of life (WHRQoL),WHO-5 Well-Being Scale was administered to assess symptom burden,emotional wellbeing and quality of life .Statistical analysis was conducted using SPSS, version 21. p value < .05 was considered statistically significant.

RESULTS

Mean age of the participants was 54.72±9.99. The patients had an improvement in emotional wellbeing mean scores from baseline(7.08± 2.93) to follow-up (13.57±5.23).The average LCS scores of patients at baseline is 15.33 and at endline is 20.5 . At the end of the trial 54.55% ,47.83% ,71.4%of the population improved on their symptom burden,quality of life ,emotional wellbeing respectively from their baseline . Paired T test witnessed a significant improvement in scores from baseline to follow up in symptoms like shortness of breath ,cough ,appetite ,tightness in chest with a significance of p<0.05. Out of the total participants, 71.4% improved on their emotional wellbeing scores from their baseline, 14.3% stayed at the same score and remaining 14.3% reduced on their score. There was a significant difference between baseline and final follow up wellbeing scores( p<.05).

CONCLUSIONS

High Symptom burden is a prognostic indicator for poor clinical outcome and is a major challenge for cancer patients, HCPs as well as caregivers. This study confirms improvement in symptom burden,Quality of life and emotional wellbeing through application of Wellthy Care PSP. Real-time feedback on patient symptoms with continuous coaching and interventions is essential for the achievement of improved outcomes even at late stage disease. Digital solutions provide growing evidence in improving patient’s clinical and health economic end points and addressing the symptom burden provides a revolutionary impact on outcomes for Lung Cancer patients.
Carbon Sequestration of Fruit Trees under Contrasting Management Regimes
Authors: Wambede Muhamud Nabalegwa , Akello Gertrude , Mulabbi Andrew , Barasa Bernard , Lugumira Jerome Sebadduka , Amonya David
Published: January 2023

This study aimed at establishing the potential of fruit trees in carbon sequestration. The specific objectives were to establish the carbon stocks in fruit trees compare the potential of carbon stocks in citrus and mango trees and examine the relationship between the management practices and carbon stocks in fruit trees. At the farm level, plots were identified and transects established and individual fruit trees from sampled individual farms along the transect were selected. At the tree level, measurements of tree height and diameter at breast height were made. They were converted to biomass using allometric equations. Analysis of Variance was used to compare the differences in carbon stocks between the fruit trees and between the different management practices.  Findings revealed higher biomass and carbon stocks in mango trees as compared to citrus (74.57 ± 14.95 and 13.52 ± 1.25 t/ha respectively). Significant differences are also reported in carbon stocks under different management practices (p < 0.05). Irrespective of the species type, above-ground carbon under different management practices followed the order (from highest to lowest): Inorganic fertilizer < Intercrop < Monocrop < organic fertilizer and irrigation < intercrop and inorganic fertilizer.  The results also point out that mango fruits have a high potential to sequestrate carbon emissions hence mitigating global warming.
Impact of ultraviolet C radiation and ozone application on the physiological quality of organic maize seeds
Authors: Maia Mayana Pereira , Silva Carine Gregório Machado , Martins Guilherme Rodrigues , Silva Danielle de Oliveira , Pereira Ana Luiza Xavier , Mamedes Artur de Souza , Passos Alexandre Martins Abdão dos
Published: January 2023

Non-thermal energy sources have been utilized to control diseases and boost the physiological quality of maize seeds. The aim of this paper was to assess the impact of UV-c exposure and ozone application, associated or not, on organic maize seed germination and seedling vigor. Three cultivars (BRS Caimbé, BRS 1060 and BR 451), three exposure levels to ozone (15, 30 and 60 minutes) in the absence and presence of ultraviolet radiation (UV-c), were used in a completely randomized design with a factorial scheme of 3 x 3 x 2 + 3 (additional treatments) experiment. Evaluations of electrical conductivity, emergence in soil, and germination (at 4th and 7th day) on paper roll were done. Daily measurements of the emerged seedlings were taken up to the 14th day after emergence. The measurements included total emergence (EC), coefficient of variation in emergence time (CVt) in percentage, coefficient of emergence velocity (CVe) in percentage, emergence rate index (ERI) in days, and emergence synchronization index (Z). The tested genotypes caused differences in all studied variables. Increasing the percentage with a 30-minute exposure to ozone in the presence of UV-C radiation resulted in a validated enhance in the first germination reading. The association of O3 and UV-c techniques can be used to treat organic maize seeds without significantly affecting their physiological quality.
Leaf Diseases Detection System Using Machine Learning
Authors: Tiwari Prof. Swati , Patle Pranjal Shyambabu , Patle Pranshu Shyambabu , Sonkusare Kuldeep Moreshwar , Mungate Pranali Shivshankar
Published: January 2023

Abstract: Agriculture supports living beings and nature in many ways, such as food and habitat. All humans as well as animals depend on the agriculture sector for their basic needs of food and nutrients. Thus, the importance of agriculture and the ways it can be improved further should be taken into account. While discussing agriculture, the topic of related diseases is not far behind. Crop disease is the most common threat that falls upon agricultural harvest. To address the issue at hand, firstly, farmers must figure out the situation on time. Then only the chance of saving the crops exists. We are aware of how the various types of diseases affect the yield badly and in turn affect the quantity. In this paper, we will detect such diseases and identify them. We will use image processing, Machine Learning Algorithms, and sample datasets to get the resulting detection.
Impurity Profiling: A Review
Authors: B Bhagwat Ashlesha , M Khedkar K.
Published: January 2023

Impurities are any substances, such as starting materials or intermediates, that coexist with the parent drug or arise from side reactions. Interest in impurities present in APIs continues to grow. Nowadays, not only purity profile but also impurity profile is mandated by various regulatory agencies.  Impurity profiling is a generic name for a group of analytical working groups such as describing, quantifying and characterizing identified and unidentified impurities present in a new drug substance.  Impurity profiling is a novel approach aimed at detecting, identifying, structuring and quantifying organic and inorganic impurities and residual solvents in pharmaceuticals.  Various regulatory bodies, such as ICH, USFDA, UKMHRA, and India's CDSCO, focus on impurity profiling and have formulated guidelines for impurity management and restriction. Impurities are classified into different categories based on their origin, type of composition, and biological safety. The presence of these unwanted chemicals or substances may affect the safety and effectiveness of the final medicinal product. This review focuses on the sources of impurities, their classification, and various analytical methods for the identification and quantification of impurities. Terms such as residual solvent, by-product, transformation product, decomposition product, reaction product, and related products are often used to define impurities.
Medicated Lozenges: A Review
Authors: Gopale Onkar , Jethawa Shraddha , Shelke Suvarna
Published: January 2023

A lozenge is a solid dose form of a medicine that is meant to dissolve in the mouth or throat. The creation of lozenges began in the 20th century and is continuing in use now. The advantages of lozenges include an increase in the duration of oral form retention in the oral cavity, which is beneficial. Bioavailability is improved. The difference lowers stomach distress and bypasses the first pass metabolism. Compressed lozenges , hard and soft lozenges are a form of lozenge that is available on the market.n this review there is a method of preparation of lozenges with materials that is required for lozenges are addressed. This review also include the research to date, classification, advantages, disadvantages, formulation evaluation, packaging, storage, uses and parameters of the study
Application of Yoga Gymnasticson Clients with Hypertension as an Effort to Lower Blood Pressure: A Case Study
Authors: S Saprianto , Putri Meti Eka
Published: January 2023

Background: hypertension is an increase in abnormal arterial blood pressure, namely blood pressure more than 140/90mmHg. Hypertension, a silent killer or "silent killer". That is a familiar nickname for hypertension or high blood pressure. Every year there is an increase in hypertension sufferers from year to year, this is due in large part to the lack of knowledge of how to treat and causes of hypertension, Broadly speaking, therapy or management of hypertension can be done in two ways, namely pharmacological management (with drugs) and non-pharmacological (without drugs), one of which is the application of yoga exercises to lower blood pressure. Objectives: To determine the effectiveness of the application of yoga exercises to clients with hypertension to reduce blood pressure. Methods: This research design uses a case study method that implements the application of yoga exercises to clients with hypertension to reduce blood pressure. Results: Researchers found that there was an effect of the application of yoga exercises on hypertensive clients on lowering blood pressure. Conclusion: After applying Yoga Gymnastics to patients with hypertension in the work area of ​​the Tanjung Agung Health Center, the researchers concluded that the Effective Yoga Exercise helps reduce blood pressure. Suggestion: Further researchers are advised to increase the number of respondents so that they can reduce blood pressure more from this study.
Development and validation of GCHSmethod used for trace level determination of carcinogenic Epichlorohydrin impurity in Rivaroxaban
Authors: Tabrez Dr. Shaikh , Gosar Dr. Amit , Mahadik Neelam , Pawar Sanjay
Published: January 2023

A simple, sensitive, and selective Headspace-Gas chromatography (GCHS) method was developed and validated for the trace level determination of Epichlorohydrin, which is a probable carcinogenic compound and may be present as a process impurity in Rivaroxaban drug substances. Identification and separation of analytes were achieved on a DB-Wax column having dimensions of 30 m in length and a 0.53 mm internal diameter with a 1.0 μm stationary film thickness. Nitrogen is used as a carrier gas with of flow rate of 6.0 mL/min. The run time of the method is 25 minutes. The gradient column oven-temperature programming method was used for analyte elution. The developed method was validated using ICH guidelines and found a linear in the range between 9.64 ppm and 80.31 ppm. The correlation coefficient and y-intercept observed for the linearity curve are 0.9993 and 1.75%, respectively. The limit of detection and quantitation were 3.03 ppm and 9.19 ppm, respectively. Recovery was observed for Epichlorohydrin between 94.66 % and 99.22 %. The RSD for system precision, precision at LOQ, and repeatability was less than 5.0 %. The developed method can be successfully applied to determine Epichlorohydrin in Rivaroxaban drug substances up to a very low trace level concentration. The method was found to be specific, selective, linear, precise, and accurate.
Formulation Development and Evaluation of Mucoadhesive Buccal Tablets of Acebutolol Hydrochloride
Authors: Chaudhari Priyanka Dilip , Deore Amol Bhalchandra , Jagtap Manoj Jagannath , Gupta Devanshi Sunil
Published: January 2023

A mucoadhesive drug delivery system is an oral dosage form, where the tablet, gel, or patch is attached to the buccal region for direct absorption of the drug into blood circulation. This dosage form has been employed to improve the bioavailability of drugs that undergoes significant hepatic first-pass metabolism. Acebutolol is a beta sympatholytic agent used to treat high blood pressure and irregular heartbeat (arrhythmia). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. In present investigation, mucoadhesive buccal tablets of acebutolol HCl were prepared using carbopol 940 in varying concentrations with secondary polymer xanthan gum by direct compression method. Nine batches were prepared as per 32 factorial designs, to investigate the combined effects of independent variables namely carbopol 940 and xanthan gum on dependant variables namely swelling index, mucoadhesion strength and in-vitro drug release using design expert software version 8.0.7.1. Preformulation studies confirmed the identity and purity of the drug by means of UV spectroscopy, IR spectroscopy, DSC analysis, and melting point determination. The tablets were evaluated for hardness, thickness, weight variation, friability, and drug content concluded that all these parameters were in an acceptable range of pharmacopoeial specification. The buccal tablets were studied for surface pH, swelling index, in vitro drug release study, adhesion force, in vitro mucoadhesive strength, stability, and compatibility study to optimise the formula. Amongst all factorial batches (F1 to F9), batch F5 (30 mg carbopol 940 and 30 mg xanthan gum) showed maximum drug release of 99.96 % after 12 hr of study and also showed better contact with biological membrane. The drug release kinetics of batch F5 was found to be best fitted to zero order kinetic model and exhibited anomalous diffusion release mechanism. The formulation F5 exhibited good correlation (R2=0.992) for in-vitro drug release. All the evaluation parameters give positive results and comply with the standards. Stability studies were carried out on the developed formulations indicating that the formulations were stable during the period of 6 months. In conclusion, the formulation F5 is stable and effective for quick action and seems to be alternative to the conventional tablet.
Potential Interactions of Hypertension Drug in Medan City Pharmacy
Authors: Wahyuni Sri , Rawitri Kiki , Rahayu Yayuk Putri
Published: January 2023

Background: Hypertension is a disease that can cause complications without the patient realizing it. Therapeutic management needed to control the patient's blood pressure is complex enough to potentially lead to drug interactions. The purpose of this study was to analyze the interaction of hypertension drugs that occurred in a pharmacy in the city of Medan.

Method: The study was conducted retrospectively involving 101 patient data in February-May 2022. Patient data was processed descriptively and potential drug interactions were analyzed using the Medscape Drug Interactions Checker, Stockley's Drug Interaction, and the drugs.com database

Result: Based on the study results, it was found that from 101 patients, 57 patients had no drug interactions (56.4%), but 45 cases of drug interactions were found in 44 patients (43.6%). Drug interactions found in 27 cases occurred pharmacokinetically (60%) and 18 cases occurred pharmacodynamically (40%). The most frequent drug interactions are Amlodipine and Simvastatin.

Conclusion: Based on this study, it can be concluded that most patients who have drug interactions occur through pharmacokinetic mechanisms.
Fabrication of Nanogel for Topical Drug Delivery of Montelukast
Authors: Pandey Trapti , Sharma Neeraj , Gupta Naveen , Gupta Dharmendra , Tripathi Kuldeep
Published: January 2023

A novel nanocrystal system of montelukast (MTK) was designed to improve the transdermal delivery, while ensuring chemical stability of the labile compound. MTK nanocrystal Nanogel was fabricated using using nano dispersion method (Modified emulsification diffusion method). In the pre-formulation study, there was not any physicochemical interaction between drug and polymer had been evaluated by FTIR. The melting point was found to be 134- 137 0C. It is freely soluble in Cyclohexane & butanol ratio and water. The standard curve of ondansetron had been prepared by Cycloheaxxane & butanol (7:3). Montelukast nanogel were prepared by nanodispersion method. Formulations of different drug ratio were optimized with selected parameters like particle size, PDI, Zeta potential, entrapment efficiency, clarity test. pH test of gel, viscosity and gelation temperature. Drug release studies were performed by dialysis bag diffusion technique at a temperature (37°C). The study was continued for 24 hours till. The maximum amount of drug montelukast release 87% within 24 hr. The study was monitored at 37°C. Preparation, characterization and drug release study of montelukast loaded nanogel. This approach of montelukast loaded nanogel with chitosan as the polymer is quite successfully developed.
The Role of Ginsenosides in Myocardial Ischemic Injury-A Systematic Review
Authors: Wenhao Song , Quanwei Wang , Wenwen Fu , Ce Zhang , Tian Wang
Published: January 2023

Topical herbal formulations are gaining more attention in wound healing due to their safety and efficacy. This is a systematic review of the effects of Curcuma longatopical formulations on wound healing. C. longa is a traditional medicinal plant used due to its antimicrobial, antioxidant, anti-inflammatory, and wound healing properties. Studies carried outas randomized control trials and clinical trials were included for the analysis of this review. Searches were conducted in PubMed, Scopus, Cochrane Central Register of Controlled Trials, and Google scholar (up to March 2022) with 04 studies meeting the inclusion criteria. All randomized control trials and clinical trials have shown a significant improvement in wound healing. The topical formulations containing C. longa as an ingredient have reportedly improved wound healing in cases of eczema, radiodermatitis, acne vulgaris, atopic dermatitis, ichthyosis vulgaris, senile pruritis, and xerotic skin conditions, according to the studies covered in this review.This review identified some evidence that C. longa extract has good effects for wound healing, in accordance with its use in traditional medicine. To evaluate the impact of C. longa on wound healing, including complications, larger, well-designed randomized control trials are required.
Educational modules as an effort to increase knowledge of cardiovascular disease risk prevention
Authors: Solihah Ii
Published: January 2023

Background: Heart disease is no longer affecting the elderly, but more and more young people are getting heart disease. An educational approach in health promotion by using attractive media is one of the most necessary ways to invite teenagers to behave in a healthy life. The purpose of this study was to determine the effect of the education module on knowledge of risk factors for cardiovascular disease prevention. The research method used a quasi-experimental design with a control group. The research sample is students at SMK Era Pembangunan 3, West Jakarta. Sampling was done by simple random sampling and a total sample of 68 people were selected. Data were analyzed using chi square test and multiple logistic regression. The results showed that the education module given to respondents could increase students' knowledge in preventing cardiovascular disease risk factors with a p value of 0.000:OR 51.83 (95% CI 9.84-273.05). Conclusion: the education module has an effect on increasing knowledge about the prevention of cardiovascular disease risk factors. Recommendations are expected that future research will develop more instruments on risk factors for cardiovascular disease.
Role of Vacha as Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Preclinical Study
Authors: Roy Shibanjan Paul , Bundela Ragini , Jain Sourabh , Shukla Karunakar
Published: January 2023

Vacha (Acorus calamus Linn (Acoraceae)) is a traditional Indian medicinal herb, which is practiced to treat a wide range of health ailments, including neurological, gastrointestinal, respiratory, metabolic, kidney, and liver disorders. The purpose of this paper is to provide a comprehensive up-to-date report on its ethnomedicinal use, phytochemistry, and pharmacotherapeutic potential, while identifying potential areas for further research. To date, 145 constituents have been isolated from this herb and identified, including phenylpropanoids, sesquiterpenoids, and monoterpenes. Compelling evidence is suggestive of the biopotential of its various extracts and active constituents in several metabolic and neurological disorders, such as anticonvulsant, antidepressant, antihypertensive, anti-inflammatory, immunomodulatory, neuroprotective, cardioprotective, and anti-obesity effects. The present extensive study is expected to provide insights into the involvement of several signaling pathways and oxidative mechanisms that can mitigate oxidative stress, and other indirect mechanisms modulated by active biomolecules of A. calamus to improve neurological and metabolic disorders.

Keywords: Acorus calamus, Acoraceae, Phytochemistry, Pharmacotherapeutic potential
Fluid fermionic fragments for optimizing quantum measurements of electronic Hamiltonians in the variational quantum eigensolver
Authors: Choi Seonghoon , Loaiza Ignacio , Izmaylov Artur F.
Published: January 2023

Measuring the expectation value of the molecular electronic Hamiltonian is one of the challenging parts of the variational quantum eigensolver. A widely used strategy is to express the Hamiltonian as a sum of measurable fragments using fermionic operator algebra. Such fragments have an advantage of conserving molecular symmetries that can be used for error mitigation. The number of measurements required to obtain the Hamiltonian expectation value is proportional to a sum of fragment variances. Here, we introduce a new method for lowering the fragments' variances by exploiting flexibility in the fragments' form. Due to idempotency of the occupation number operators, some parts of two-electron fragments can be turned into one-electron fragments, which then can be partially collected in a purely one-electron fragment. This repartitioning does not affect the expectation value of the Hamiltonian but has non-vanishing contributions to the variance of each fragment. The proposed method finds the optimal repartitioning by employing variances estimated using a classically efficient proxy for the quantum wavefunction. Numerical tests on several molecules show that repartitioning of one-electron terms lowers the number of measurements by more than an order of magnitude.
An Improved Sample Complexity Lower Bound for (Fidelity) Quantum State Tomography
Authors: Yuen Henry
Published: January 2023

We show that Ω(rd/ϵ) copies of an unknown rank-r, dimension-d quantum mixed state are necessary in order to learn a classical description with 1–ϵ fidelity. This improves upon the tomography lower bounds obtained by Haah, et al. and Wright (when closeness is measured with respect to the fidelity function).
Kaedah Pengilmuan Swacuan
Authors: Mohamad Zain Shaharir bin
Published: January 2023

It is explained that knowledge grows in a mould created by scholars concerned and the meaning of a mould of knowledge is shown to have different features than the famous knowledge paradigm introduced by Kuhn in 1962. The present science is shown to be in a mould created by the European (Western) scientists, whereas the knowledge in other moulds created by other nations or civilisations do exist but fossilised or stagnated as they are overlaid or enclosed and restricted by the colonial (Western) mould. Knowledge in other mould is given the name by the European scholars as the ethnoknowledge which is regarded as far inferior than the Western knowledge. But since 1960s the knowledge in the Islamic Civilisation is re-excavated and highlighted its mould as well. In 1970’s to especially 1990’s the Western knowledge is re-examined in the Islamic mould and a new knowledge is materialised in this mould via a research activity known as the Islamization of knowledge. But since 1995, the author introduced a new research activity wider than the Islamization of knowledge and it is given the name as the pemeribumian ilmu (or literally but not the same concept as the Western indigenisation of knowledge). The mould of knowledge in the pemeribumian ilmu is referred to as the our own mould or in short self-mould and more specific as the Malayonesian mould of knowledge. The research activity is referred to as the self-moulding of knowledge or construction of knowedge via a self-mould. This article is filled with the explanation of this activity and some results of the research done by the author since 2010-2021 are listed in the appendix of this paper.
Pemikiran Tuan Minal dalam Membahaskan Aspek Mabadi ‘Ilm Tawhid dan Ilah dalam Kitab `Aqidah al-Najin
Authors: Yusoff Pauzi , Hamat Mohd Fauzi , Mohamed Adnan Mohamad Azrien
Published: January 2023

One of Nusantara's experts, Tuan Minal, is adamant on publishing works, particularly in the area of religion. The `Aqidah al-Najin fi `Ilm Usul al-Din, his book, is still in use today. This article will briefly explain the book `Aqidah al-Najin, which also discuss the peculiarities of this book in terms of definition, Mabadi `Ilm Tawhid and ilah. This study uses a qualitative method where the book `Aqidah al-Najin is used as a primary source, while the process of analyzing the data is to use the method of content analysis of the book by making a comparative analysis of the work with several other scholars of the archipelago. The paper summarizes that Tuan Minal attaches great importance to the aspect of accuracy by choosing the right and appropriate words to make a definition. In addition, Tuan Minal tried to compile ten Mabadi 'Ilm Tawhid in learning the science of tawhid well and organized and carefully in discussing matters related to the divine spirit.
The Issue of Intellectual and Civilizational Decadence: An Analysis of Syeikh Muhammad al-Ghazzāli’s Discourse
Authors: Mohd Daud Noor Amali
Published: January 2023

The issue of intellectual and civilizational backwardness ‘takhalluf’ is one of the most important issues debated in the modern Islamic discourse, especially in the early twentieth centuries. What are the factors underneath the decline of the Muslim Ummah?How it affect its present conditions?, and how to resolve the problem and bring about strategic transformation to this current situation? This article attempts to investigate the issue from Muhammad al-Ghazzālī’s scholarly insight, focusing on some of main factors deliberated by al-Ghazzālī as significant factors to Muslim decline and backwardness in the intellectual and civilizational realms. Al-Ghazzālī identified two major causes of decadence, namely internal as well external factors. Al-Ghazzālī also offers his intellectual insights on remedies for the crisis towards the betterment of Muslim nations.
Maleo Birds Egg-Laying Behavior (Macrochepalon maleo) In Kuala Vuno Area, Oloboju Village, Sigi District, Central Sulawesi Province
Authors: Afandi  , Rusyiantono Yohan , Tanari Mobius
Published: January 2023

Maleo (Macrocephalon maleo)  termasuk famili Megapodiidae yang merupakan fauna langka dan endemik Pulau Sulawesi. Keistimewaan jenis burung maleo yaitu memiliki telur lebih besar 4-5 kali dari telur ayam kampung, meskipun besar tubuhnya relatif tidak jauh berbeda dengan jenis ayam, dengan warna kerabang telur mendekati warna merah dadu. Penelitian bertujuan mendapatkan gambaran mengenai perilaku bertelur maleo di Kawasan habitat Kuala Vuno Desa Oloboju Kabupaten Sigi Provinsi Sulawesi Tengah. Penelitian menggunakan metode survey dan dianalisis secara deskripif. Peubah yang diamati yaitu perilaku bertelur sebelum bertelur, saat bertelur dan setelah bertelur. Hasil penelitian menunjukkan bahwa perilaku bertelur maleo di Kawasan Habitat Kuala Vuno Desa Oloboju Kabupaten Sigi Provinsi Sulawesi Tengah dimulai dari maleo mendatangi habitat peneluran, melakukan pengintaian pada lokasi yang dituju, lalu menggali lubang untuk meletakkan telur pada lokasi yang aman. Apabila lubang sudah siap maka maleo betina masuk ke dalam lubang untuk bertelur selama beberapa menit sementara maleo jantan mengawasi selama burung maleo betina dalam proses bertelur. Setelah burung maleo betina keluar dari lubang peneluran maka sepasang burung maleo tersebut menimbun dan meninggalkan habitat penelurannya.
Adoption of Cattle Breeders to Livestock Business Management in Balaesang Tanjung District, Donggala District, Central Sulawesi
Authors: Evan Linda , Mujayin Yudi
Published: January 2023

Pengelolaan sektor peternakan Sulawesi Tengah masih termasuk dalam kategori belum optimal. Jika dilihat dari aspek manajemen usaha, umumnya masih dilakukan secara ekstensif atau dikelola berdasarkan kondisi alamiah dan tidak sesuai kebutuhan dasar ternak serta tata kelola yang baik. Penelitian ini bertujuan untuk mengetahui adopsi peternak sapi terhadap manajemen usaha peternakan dan faktor-faktor yang mempengaruhinya. Penelitian dilaksanakan pada 4 Desa di Kecamatan Balaesang Tanjung yaitu Desa Walandano, Malei, Palau dan Pomolulu, pada bulan September - Oktober 2020. Metode yang digunakan dalam penelitian ini adalah sensus, observasi dan wawancara langsung di lapangan. Data dianalisis menggunakan analisis statistik deskriptif. Hasil penelitian menunjukkan bahwa tingkat adopsi peternak terhadap manajemen usaha peternakan sudah sangat baik dengan persentase yaitu peternak mengetahui manajemen usaha (90 %), peternak mengetahui tujuan manajemen usaha peternakan (91%), peternak mengetahui keuntungan beternak sapi (91%), peternak mengetahui manajemen usaha peternakan sapi potong dapat meningkatkan kualitas dan produktivitas ternak (58%), peternak melakukan perubahan manajemen usaha sapi potong (99%), peternak merasakan manajemen usaha sapi memberikan kontribusi terhadap kesejahteraan peternak (97%), dan peternak telah melakukan tahapan manajemen usaha sapi (70%).
Pemberian Hak Asuh Anak Kepada Ibu yang Murtad
Authors: Apriliani  , Sasmito Seno Aris
Published: January 2023

This study aims to determine the maṣlaḥah of article 105 of the Compilation of Islamic Law in granting child custody to apostate mothers. This type of research includes library research namely, research that deals directly with text or data, so the typr of research used is a qualitative tipe. The conclusion is that article 105 of the Compilation of Islamic Law as the basis for granting child custody at the Surakarta Religious Courth has achieved the goal the sharia, namely creating and seeking the benefit of children in line with maṣlaḥah.
Pemenuhan Hak Anak Pasca Perceraian dalam Perspektif Undang-Undang Nomor 35 Tahun 2014 Tentang Perlindungan Anak dan Kompilasi Hukum Islam
Authors: Muhammad Luqman Asshidiq  , Diana Zuhroh
Published: January 2023

This study is about the fulfillment of children's rights after divorce in the perspective of Law Number 35 of 2014 concerning Child Protection and the Compilation of Islamic Law. This research is motivated by problems in the family, where after the occurrence of a divorce, due to several factors the parents do not give the right to a living, maintenance and education to children as they should and prefer to be entrusted to their grandmothers or grandfathers. The data sources used in this study came from four families with the first criterion, their parents were divorced. Secondly, the child was abandoned when theywere toddlers and entrusted to their grandmother or grandfather. The results of the study indicate that in Dukuh Gandurejo, Gemolong Village, Gemolong District, Sragen Regency, parents are still obliged to fulfill children's rights including custody rights (hadanah), maintenance rights, and education even though the parents are divorced. This has been regulated in positive laws such as Law Number 35 of 2014 concerning Child Protection and the Compilation of Islamic Law as well as in the regulation explaining in detail the sanctions for parents if they do not give rights in the form of maintenance to children.
Guillain-Barre Syndrome Secondary to COVID-19 Infection: A Case Report
Authors: Tran Dena , Basra Dalwinder , Bilgrami Zaid , Challa Suryanarayana Reddy , Kwon Christina , Marciniak Ellen , Verceles Avelino
Published: January 2023

Guillain-Barre syndrome (GBS) is a rare autoimmune disease that often
manifests as a post-viral complication. However, its association with
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is unclear.
We present a rare case of GBS secondary to COVID-19 infection
complicated by rapidly progressive sensorimotor deterioration resistant
to plasma exchange therapy.
Misdiagnosis of persistent left superior vena cava with unroofed coronary sinus as a coronary sinus-type atrial septal defect
Authors: Al-Dairy Alwaleed , Ahmad Reem , Hasan Rawan
Published: January 2023

Unroofed coronary sinus syndrome may be associated with persistent left
superior vena cava (PLSVC). Herein, we present a case of a 2-year-old
patient who underwent an operation for repair of a coronary sinus-type
ASD; however, PLSVC was detected intraoperatively. total repair was
performed by creating an intra-atrial tunnel.
Spatial correlation characteristics and mechanism of cultivated land fragmentation and cultivated land quality in the Central Plain of Liaoning ，Northeast China
Authors: Pang Ranran , Xu Huan , Zhang Meiyu , QIAN FENGKUI
Published: January 2023

In order to reveal the spatial correlation characteristics and action
mechanism of cropland fragmentation and cropland quality, this study
takes the central plain area of Liaoning as an example, constructs the
evaluation system of cropland “area-shape-distribution” fragmentation
and cropland natural-standing quality, and explores the effect of
cropland fragmentation on cropland quality based on the evaluation using
bivariate spatial autocorrelation method and spatial lag model. The
results showed that the quality of cropland in the Central Plain region
was affected by the fragmentation. The results showed that the overall
degree of cropland fine-fragmentation in the central plain area was
light, and the cropland quality showed a spatial distribution trend of
“high in the middle and low at both ends”. There was a negative
spatial correlation between cropland fine fragmentation and cropland
quality. The increase of the number of patches (NP), boundary density
(ED) and aggregation degree (AI) in the central plain area will hinder
the improvement of the cultivated land quality. When the NP, ED and AI
values in the evaluation unit increased by 1 unit, the cropland quality
in the central plain area decreased by 0.275, 1.306 and 1.085,
respectively.