bluuebunny/crossref_metadata_2025 huggingface dataset:
UPF2 is a differentially expressed gene in brain metastatic human breast cancer.
Authors: Mamoor Shahan
Published: February 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that regulator of nonsense transcripts 2, encoded by UPF2, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. UPF2 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of UPF2 in primary tumors was significantly correlated with patient post-progression survival. Modulation of UPF2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
ABE10: MHC Class I H-2Kb-INFDFNTI-BM3.3 TCR complex: convergence diagnostics of internal energy
Authors: Antipas Georgios S.E. , Ntallis Nikolaos , Karalis Konstantinos
Published: February 2021

ABE10: MHC Class I H-2Kb-INFDFNTI-BM3.3 TCR complex: convergence diagnostics of internal energy
U-Penn Psych hosting the package ‘bayesvl’
Authors: AISDL
Published: February 2021

U-Penn Psych hosting the package ‘bayesvl’The Comprehensive R Archive Network (CRAN)Access date: February 15, 2021 http://finzi.psych.upenn.edu/library/bayesvl/html/00Index.htmlOpen-source library server
Factsheet: Who is sending and sharing potentially harmful digital communications?
Authors: Melhuish Neil , Pacheco Edgar
Published: February 2021

This factsheet presents findings from a quantitative study looking at adults’ experiences of sending and sharing potentially harmful digital communications in New Zealand. Typically research into harmful digital communications focuses on the experiences of those on the receiving end – the victims. However, to better address the distress and harm caused, information is needed about the people sending and sharing potentially harmful messages and posts. In this study we asked adult New Zealanders whether they had sent potentially harmful digital communications in the previous year and if so, how often they had done this, who they were sent to, the channel(s) they used, and the reason for doing this.
Vietnam Post xây dựng văn hóa doanh nghiệp
Authors: AISDL
Published: February 2021

Trong một doanh nghiệp, đặc biệt là những doanh nghiệp có quy mô lớn, là một tập hợp những con người khác nhau về trình độ chuyên môn, trình độ văn hóa, mức độ nhận thức, quan hệ xã hội, vùng miền địa lý, tư tưởng văn hóa… chính sự khác nhau này tạo ra một môi trường làm việc đa dạng và phức tạp. Bên cạnh đó, với sự cạnh tranh gay gắt của nền kinh tế thị trường và xu hướng toàn cầu hóa, buộc các doanh nghiệp để tồn tại và phát triển phải liên tục tìm tòi những cái mới, sáng tạo và thay đổi cho phù hợp với thực tế.
Danh sách tác phẩm, tác giả đoạt Giải báo chí quốc gia 2010
Authors: AISDL
Published: February 2021

Lễ trao Giải báo chí quốc gia lần thứ V - 2010 đã được tổ chức trang trọng tối 21/6/2011, tại Thủ đô Hà Nội. Dưới đây là danh sách toàn bộ các tác phẩm, tác giả, nhóm tác giả đoạt Giải (theo 8 loại Giải).
Công ty Tư vấn Quản lý OCD: Văn minh làm giàu và Nguồn gốc của cải
Authors: Lab SDAG
Published: February 2021

Công ty Tư vấn Quản lý OCD: Văn minh làm giàu và Nguồn gốc của cải. URL: https://ocd.vn/index.php/vi/news/trithuc-quanly/803-tri-thuc-quan-ly.
Low Vision Devices for Age-Related Macular Degeneration: A Systematic Review
Authors: Macnamara Anne , Chen Celia , Davies Andrew , Sloan Charlotte , Loetscher Tobias
Published: February 2021

Purpose: Age-related macular degeneration (AMD) is a degenerative condition impacting central vision. Evaluating the effectiveness of low vision devices provides empirical evidence on how devices can rehabilitate and overcome deficits caused by AMD. This evidence could help to facilitate discussion on necessary future improvements to vision enhancement technology.Methods: A systematic review of the literature was conducted on low vision devices use in AMD populations. Relevant peer-reviewed research articles from six databases were screened. Results: The findings of thirty-five studies revealed a significant positive impact of low vision devices leading to improvements in visual acuity, reading performance, facial recognition, and more. While the studies were found to have moderate risks of bias, a GRADE assessment of the evidence suggested the certainty of the evidence was low-moderate.Discussion: Simple hand-held low vision devices (e.g., magnifiers) appear to currently have greater preferential support than newer visual enhancement technology (e.g., head mounted devices). Financial, comfort or usability reasons may influence preferences more than performance-based findings. However, there is a lack of studies examining newer technologies in AMD populations, which future research should address. Moreover, given the presence of bias across the studies and limited controlled experiments, confidence in the results may be low. Conclusions: Most studies indicated that low vision devices have positive impacts on reading and visual performance. But, even though they are reported to be a valuable asset to AMD populations, more rigorous research is required to draw conclusive evidence.
Theoretical evaluation of partial credit scoring of the multiple-choice test item
Authors: Persson Rasmus Anders Xerxes
Published: February 2021

In multiple-choice tests, guessing is a source of test error which can be suppressed if its expected score is made negative by either penalizing wrong answers or rewarding expressions of partial knowledge. Starting from the most general formulation of the necessary and sufficient scoring conditions for guessing to lead to an expected loss beyond the test-taker’s knowledge, we formulate a class of optimal scoring functions of which that due to Zapechelnyuk (Economics Letters, 132, 2015) appears as a special case. We then consider an arbitrary multiple-choice test taken by a rational test-taker that knows an arbitrary fraction of its keys and distractors as a model of a test of factual knowledge. For this model, we study the statistical properties of the obtained score for both standard marking (where guessing is not penalized), and marking where guessing is suppressed either by expensive score penalties for incorrect answers or by different marking schemes that reward partial knowledge.
The myth of visual “depth cues” III. “Occlusion/Interposition
Authors: Maniatis Lydia
Published: February 2021

Occlusion” or “interposition” are typically described as “visual depth cues.” This is not a rational claim.
The Use of the Term Rapport in the Investigative Interviewing Literature: A Critical Examination of Definitions
Authors: Neequaye David A. , Mac Giolla Erik
Published: February 2021

Researchers typically note that there is much divergence about how rapport is defined in the investigative interviewing literature. We examined the scope of this divergence, the commonalities of extant definitions, and how the current state of affairs impacts the scientific investigation of rapport. We obtained 228 publications that discussed rapport in an investigative interviewing context. Only Thirty-two publications (14%) explicitly defined rapport. Twenty-two of those definitions were unique. All of the definitions implied that rapport centers on the quality of the interviewer-interviewee interaction. However, the definitions ascribed different attributes when describing more specifically how rapport relates to the quality of interpersonal interactions. A thematic analysis revealed six major attributes by which rapport could be characterized. The attributes were communication, mutuality, positivity, respect, successful outcomes, and trust. These attributes were disparately distributed across the definitions. Based on the considerable disparity in its definitions, we question the theoretical and practical value of the term rapport. The current situation creates ambiguity about the meaning of rapport and impedes its objective assessment. To avoid further ambiguity, we believe the field must collectively determine a finite set of attributes to denote the term rapport. Until those attributes are determined, stakeholders should stop indiscriminately using the word rapport to describe any collection of attributes of the interviewer-interviewee interaction.
Coping and co-creation: one attempt and one route to well-being
Authors: Andringa Tjeerd C. , Denham Florence C.
Published: February 2021

All life strives to be well, but not all life is well. In this theoretical article we systematically specify the evolutionary core cognition of well-being in general living agents and we apply that to humans. We identify two strategies for the creation and protection of the conditions required for well-being and describe the associated behavioral ontologies. One strategy, coping, is for survival and the other strategy, co-creation, is for thriving. We summarize core cognition and the ontologies in two tables with defined key terms.Coping and co-creation correspond to two complementary ontologies of cognition that follow their own internal logic fine tuned by learned from real-world experiences. While both strategies are essential, the successful interplay of their strengths leads to the dominance of one of them: co-creation.We define adequacy in terms of improving or protecting viability, and we show that the four combinations of a coping and co- creation adequacy or inadequacy underlie the structure of identity in humans. The combinations also dictate how individuals attempt to protect and create the conditions for well-being, and their likelihood of success.The notion of ontological security, as it is known in literature, is an accurate description of the coping mode’s restricted capacity for the creation and protection of well-being. Ontological security leads to a self-limiting form of well-being that has been described as “abnormal normality”.Psychological safety provides the preconditions for high well-being and a safe environment promoting the healthy development of coping and co-creation adequacy.
An Inclusive Existential Positive Psychology: A Commentary
Authors: Jans-Beken Lilian
Published: February 2021

This is a commentary to dr. Paul T.P. Wong's article Existential Positive Psychology (PP 2.0) and global wellbeing: Why it is Necessary During the Age of COVID-19, published in the International Journal of Existential Positive Psychology. Publication can be found at https://www.meaning.ca/ijepp-article/vol10-no1/an-inclusive-existential-positive-psychology-a-commentary/
Confidence in the police in Scotland: Trends in Scottish Crime and Justice Survey responses, 2012/13‐2017/18
Authors: Matthews Ben , McVie Susan , Murray Kath , Norris Paul
Published: February 2021

This report presents a high-level analysis of trends in overall confidence in the police in Scotland between 2012/13 and 2017/18 using data from four sweeps of the Scottish Crime and Justice Survey (SCJS) conducted in 2012/13, 2014/15, 2016/17 and 2017/18. The paper was prepared for the Scottish Police Authority Policing Performance Committee meeting on 2020/05/28 (https://www.spa.police.uk/meetings/policing-performance-committee/28-may-2020/)
Who are the 100 Largest Scientific Publishers by Journal Count? A Webscraping Approach
Authors: Nishikawa-Pacher Andreas
Published: February 2021

Meta-scientific surveys at the publisher- and journal-level cannot attain comprehensiveness if they omit large and middle-sized publishers. To hedge against this risk of biased omissions, one would need an exhaustive list of major scientific presses and their journals. This paper explores whether webscraping multiple heterogeneous research-related platforms could attain this goal. In a first step, the project draws from the content coverages of Scopus, Publons, DOAJ and SherpaRomeo to extract a preliminary list of publishers that supposedly possess at least 15 journals. In a second step, the project scrapes each of the publisher’s website to fetch their respective journal portfolios. The outcome is a list of 100 publishers comprising 28.060 journals. Many of the publishers, especially university presses from the Global South, would have been overlooked if one had drawn from merely one or two sources. Surprisingly, almost a third of the major publishers (32 out of 100) covering 4.744 journals seems predatory. Despite some limitations (e.g., the non-uniform distribution of the data, or the difficulty of disambiguating publisher names and their imprints), the dataset can serve as a useful basis for large-scale scientometrics analyses investigating the landscape of academic publishers and scholarly journals.
Assigner of genitive case in Mandarin
Authors: LI DIANCHENG
Published: February 2021

Studies have shown that there are several types of 'de' in Mandarin Chinese and a united conclusion has not been drawn from the previous approaches and investigations. Some scholars argue that one type of 'de' is treated as a possessive marker and have provided syntactic justification of it. My goal is to examine whether 'de' can assign genitive cases by means of a contrastive analysis applying X-bar theories proposed by Chomsky (1981, 1986). In addition to this, I also adopt the expression of logical form (LF) and phonetic form (PF) suggested by Chomsky (2015) so as to seek a justification for answering why 'de' can be omitted (covert) in some specific cases. Providing that a conclusion is reached, the present research will strengthen the idea that 'de' may be an assigner of the genitive case. I will further explore the construction of the recursion of the determiner phrases headed by "de" in Mandarin and headed by "’s" in English and then I will provide a contrastive analysis of the analogue recursive construction in Spanish.
Drivers and challenges of electric vehicles integration in corporate fleet: An empirical survey
Authors: Di Foggia Giacomo
Published: February 2021

Low-carbon economy roadmaps aim to reduce transport emissions by relying, at least to some extent, on electric vehicles. The uptake of electric vehicles on a mass scale requires the simultaneous adoption of such vehicles for private and commercial purposes. Although literature regarding the private sphere is consistent, there is comparatively less empirical research seeking to explain the factors that enable and hinder the uptake of electric vehicles at a commercial level at which fleet managers have a prominent role. Based on an empirical survey conducted in Italy, this paper investigates the role of technical and financial information in fleet managers’ procurement decision-making. Results suggest a lack of awareness regarding technical characteristics of vehicles, given that 59% of the fleet managers surveyed scored low to medium. Furthermore, a misalignment related to the expected investment payback period was observed, considering that 49% declared that they expect a payback period within three years. Given that exposure to electric vehicles within fleets constitutes an incentive for private purchase, well-designed policies for corporate fleets’ electrification would lead to remarkable growth of the electric vehicles market.
Traditional Institutions in Africa, Past and Present
Authors: Neupert-Wentz Clara , Müller-Crepon Carl
Published: February 2021

To what degree and why are traditional institutions persistent? Following up on the literature on the long-term effects of precolonial institutions in Africa, we investigate whether today's traditional institutions mirror their precolonial predecessors. We link new data on traditional institutions of African ethnic groups with Murdock's Ethnographic Atlas. We find a robust association between past and present levels of centralization. However, this persistence originates almost exclusively from former British colonies governed with more reliance on precolonial institutions than other colonies, in particular French ones. These findings contribute to research on the development and effects of traditional institutions, highlighting the need to theoretically and empirically differentiate between what we call institutional persistence and persistent effects of past institutions.
Satire in Shrestha’s Ghintang Ghishi Twank
Authors: Rai Man Kumar
Published: February 2021

The objective of this article is to analyze the use of satire in three poems, from Rupesh  Shrestha’s volume of poems Ghintang Ghishi Twank in order to examine use of the suffering of voiceless people. The poems depict absurdities of the society and hypocrisy of the leaders which are the causes of poor people‟s pains. This poems exhibit how follies, vices and absurdities are hurdle in transforming society into prosperous one. The poet has berated them with the aim of bringing positive change in the society and in the lives of the common people. The poet mocks at the political changes which have brought change only in the lives of political leaders, not in the lives of the people who have been ignored by the state for long. Despite many anxieties, they enjoy dancing and playing sticks in their hands on the special occasion of Gaijatra. The poems are collection of sharp words which are used to butt the corrupt politicians. For this, the elements of Juvenalian satire have been used as tools for analysis of the selected poems. This study highlights upon the anxieties of marginalized people; demonstrates the shameful act of politicians; and exposes the absurdities prevailed in the society. It indicates that the political and social absurdities are subject to be poked in order to reform a society.
Water quality and land use/cover changes in the Phewa Watershed, Gandaki Province, Nepal
Authors: Bishwakarma Kiran , Pant Ramesh Raj , Pal Khadka Bahadur , Ghimire Archana , Thapa Lal B , Saud Prem , Joshi Susan , Panthi Khim Prasad
Published: February 2021

Knowledge and understanding of land use and water quality nexus is an important precursor for assessing the human-water interactions and sustainable freshwater management. In this study, the land use/cover change (LUCC) and water quality assessment with respect to drinking and irrigational purposes were carried out in Phewa Lake, Nepal. A total of 20 water samples were collected during the winter and summer seasons in 2017 and were analysed for major hydrochemical variables. The water quality index of Phewa Lake was found to be 5.15 and 2.57 during the winter and summer, respectively, indicating the suitability of water for drinking purposes. The results revealed that the electrical conductivity, sodium percentage, and sodium adsorption ratio were found to be 38.80 µS/cm, 16.99, and 0.10, respectively in the summer and 85.06 µS/cm, 14.68, and 0.15, respectively in the winter. Similarly, permeability index, Kelly’s ratio, magnesium hazard, cation ratio of soil structural stability, and Wilcox diagram exhibited that the water was suitable for irrigation in both seasons with relatively better quality in the summer. The dynamic pattern of LUCC in the Phewa watershed exhibited an increase in the spatial extent of forest, shrub-land, grassland, and built-up area, whereas decreasing trend of agricultural land, barren land, and water bodies. Irrespective of the seasonality, the LUCC-water quality nexus showed elevated concentrations in the proximity of the urban settlements. The present study could be helpful for the restoration of water quality by sustainable land-use practices in the Himalayan region.
CLUSTERING PENCAPAIAN TARGET PENJUALAN RUMAH PARA KARYAWAN MARKETING MENGGUNAKAN RAPID MINER DAN ALGORITMA K-MEANS
Authors: Julianto Muhammad Fahmi , Hadi Sofian Wira , Setiaji Setiaji , Gata Windu , Pebrianto Rangga
Published: February 2021

In the competition of the business world today, we are required to always develop business in order to always be successful in competition. Fachry PropertyLand is one of the business fields engaged in the sale of homes. Everywhere this shop must meet the needs of customers who are currently trending. On Land Fachry Property Around the issue that always appears regarding sales. Where many employees do not meet their sales targets. Based on this, it is expected to facilitate the Land Fachry Property in assessing the appropriateness of its employees in determining employees who have met the target, has not met the target and does not meet the target, in the grouping process, the grouping method will be used using the K-Me Clustering Algorithm as a method of manual replacement and in its implementation the Data Mining software uses RapidMiner Studio version 9.2. With the application of Rapid Miner Studio, it is expected that the owner of Fachry Propertyland can see the results of the grouping that meets the target, does not meet the target and does not meet the target. It is expected that the owner of Fachry Propertyland can take action on these employees.
PENERAPAN METODE TECHOLOGY ACCEPTANCE MODEL PADA PENILAIAN KINERJA KARYAWAN
Authors: Utami Sri
Published: February 2021

TAM merupakan suatu model yang bisa mendefenisikan sejauh mana persepsi kemanfaatan. Dengan metode TAM diharapkan dapat memberikan pembuktian bahwa kinerja karyawan bisa baik salah satu faktor dipengaruhi oleh gaya kepemimpinan ditempat karyawan tersebut bernaung. Sehingga diharapkan kedepannya bisa menjadi acuan untuk pimpinan dan karyawan untuk bisa berkolaborasi demi kemajuan perusahaan. Pemimpin bisa mempertahankan kualitas bahkan meningkatkannya dan membagi ilmu kepada karyawan agar semua pekerjaan yang menjadi tanggungjawabnya bisa terselesaikan dengan hasil yang maksimal.
Üniversite Kariyer Merkezlerinin Dünyadaki Gelişimi ve Türkiye Örneği
Authors: GÜLMEZ Neşe , OKUR Mehmet Emin
Published: February 2021

Gençlerin daha iyi bir kariyere sahip olma istekleri yükseköğretime olan ilgiyi her geçen gün önemli oranda arttırmaktadır. Gelişmiş ülke örnekleri incelendiğinde ise öğrencilerin bu talebini karşılamak üzere, istihdam edilebilirliği arttırmak ve kariyer gelişimini desteklemek amacıyla üniversitelerde Kariyer Merkezleri’nin kurulduğu görülmektedir. Bu merkezlerin, öğrenciler dışında işverenler, eğitim kurumları ve devletler için de önemli olduğu bilinmektedir. Mevcut çalışmada, çeşitli paydaş grupları için kritik önem arz eden “Kariyer Merkezlerinin” ülkemizdeki ve farklı kültürlerdeki tarihsel gelişimi sistematik bir yaklaşımla ortaya koyulmaktadır.
Telaah Pembelajaran Menulis Puisi dengan Cerita Rakyat Betawi Berdasarkan Pendekatan Intertekstual
Authors: Hidayatullah Syarif , Puspitasari Nur Aini , Dewi Trie Utari
Published: February 2021

Penelitian ini bertujuan untuk mengetahui cara mahasiswa dalam menulis puisi berdasarkan cerita rakyat Betawi. Untuk mengetahuinya hal tersebut, metode yang digunakan adalah dengan teknik analisis isi dengan pendekatan intertekstual. Teks puisi yang ditulis mahasiswa dianalisis berdasarkan pola-pola transformasinya dari hipogram berupa cerita rakyat Betawi. Puisi yang dianalisis sebanyak 31 puisi yang ditulis oleh 26 mahasiswa berjenis kelamin perempuan dan 5 mahasiswa berjenis kelamin laki-laki. Hasil penelitian ini ditemukan tiga  fenomena menarik, yaitu mayoritas mahasiswa melakukan pola ekserp dibandingkan dengan pola lainnya. Kedua, mahasiswa melakukan proses transformasi pada cerita-cerita rakyat Betawi yang cenderung populer. Ketiga, mahasiswa berjenis kelamin perempuan lebih memilih cerita berkonflik percintaan, sebaliknya mahasiswa berjenis kelamin laki-laki lebih memilih cerita berkonflik kekerasan.
Developing Local Wisdom Content in West Kalimantan as English Language Teaching Material
Authors: Barella Yusawinur
Published: February 2021

English is an international language, and almost all Indonesians are aware that most of the teaching materials that use English contain foreign cultural content and topics from abroad. This will cause students to be less aware of the culture of the nation, because they are more focused on understanding foreign cultures. This problem will be incompatible with the goals of national education, which emphasize the development of national cultural identity and the formation of virtuous character, as well as the competitiveness of human resources for the Indonesian nation. This research is the development of teaching materials that aim to produce a product that will later be useful for students in improving their English language skills. In this study also discusses how a teacher can manage their teaching from rich local materials and resources into attractive teaching and learning management.As a teaching material, the product produced is English-language material, using easy-to-understand vocabulary, and is not accompanied by practice questions at the end of the reading, so that students can read calmly.
Analisis Kesalahan Sintaksis Mahasiswa dalam Menulis Paragraf Menggunakan Bahasa Inggris
Authors: Ramadhiyanti Yulia
Published: February 2021

Tujuan penelitian adalah untuk mengetahui jenis-jenis kesalahan yang dilakukan oleh mahasiswa dalam menulis sebuah paragraf bahasa Inggris dan untuk mengetahui jenis-jenis kesalahan yang umumnya banyak dilakukan oleh mahasiswa tersebut. Penelitian menggunakan pendekatan deskriptif kualitatif dengan metode analisis. Teknik pengumpulan data menggunakan observasi dan pengukuran dan alat pengumpulan data menggunakan lembar observasi dan tes tertulis. Hasil analisis menunjukkan bahwa kesalahan-kesalahan yang ditemukan adalah: (1) kategori sintaksis dan strategi permukaan, berupa kesalahan pada noun phrase, verb phrase, transformation, dan miscellanous. Kemudian pada kategori permukaan, jenis-jenis kesalahan yang ditemukan adalah kesalahan penghilangan, penambahan, kesalahan bentuk, kesalahan urutan, dan pensubtitusian. Kesalahan sintaksis yang paling dominan pada tulisan mahasiswa adalah kesalahan pada noun phrase; dan (2) pada kategori taksonomi komunikatif, tidak terdapat kesalahan yang menyeluruh, hanya ditemukan sedikit kesalahan saja, artinya walaupun dalam frase atau kalimat tersebut terdapat kesalahan sintaksis, pesan yang disampaikan masih bisa dimengerti oleh pembaca.
O slici Krštenje vladara iz Strossmayerove galerije starih majstora
Authors: Pasini Tržec Iva
Published: February 2021

Na temelju istraživanja arhivske dokumentacije, aukcijskih kataloga te oznaka na poleđini slike Krštenje vladara iz Strossmayerove galerije starih majstora HAZU autorica iznosi brojne nove spoznaje o provenijenciji slike tijekom 19. i prve polovice 20. stoljeća. Utvrđuje da se slika nalazila u vlasništvu Williama Grahama (1817. – 1885.), jednog od značajnijih skupljača i pokrovitelja umjetnika viktorijanskoga doba te prati tijek prodaja slike posredstvom aukcijske kuće Christie’s u Londonu sve do 20-ih godina 20. stoljeća. Razmatra i okolnosti ulaska slike u zbirni fond Strossmayerove galerije u neposrednom poraću te vraća memoriju na pretposljednjega vlasnika slike, poduzetnika Oskara Fröhlicha (1879. – 1944.). Istraživanja provenijencije slike upotpunila su saznanja o izvornoj cjelini, odnosno o postojanju pandana Posveta Panteona te omogućila korigiranje i novo tumačenje ikonografije slike.
Öfke Kontrol Sorununun Bilişsel ve Davranışçı Psikoterapisi: Bir Olgu Sunumu
Authors: AYDIN Şule , ARCAN Kuntay
Published: February 2021

Öfke bilişsel, duygusal ve fizyolojik bileşenlerden oluşan yaşantısal bir durumdur. Öfkenin işlevsel olmayan yollarla ifade edilmesi mesleki, sosyal, fiziksel ve yasal sorunların yaşanmasına neden olabilir. Öfkeyle ilgili zorlukların yaygınlığı ve yıkıcı sonuçları, bu zorlukların tedavisini önemli hale getirmektedir. Bilişsel ve Davranışçı Terapi (BDT), öfke kontrolünde yaygın olarak kullanılan etkili bir yaklaşımdır. Bu olgu sunumunda, öfke kontrol sorunu yaşayan 37 yaşında bir kadın danışanın, BDT yaklaşımıyla yürütülen 12 seanslık psikoterapi süreci aktarılmıştır. Öfke hakkında psiko-eğitim verilen danışandan öfkelendiği durumlar için kayıt tutması istenmiştir. Bu sayede danışan öfke duygusuyla ilişkili belirtileri ve durumları fark etmiş, öfkelenebileceği durumlar için proaktif düzenlemeler yapmıştır. Öfkesi şiddetlendiğinde “dur-düşün-davran” sıralamasını izlemesi ve saldırgan davranışlarını kendisine “dur” komutu vererek ertelemesi sağlanmıştır. Öfkelendiği zamanlardaki bilişsel çarpıtmaları tanımış ve düşüncelerini değiştirmeye başlamıştır. Değersiz olma inancını, hakkındaki olumsuzlukların bilinmemesi halinde yargılanmayacağı varsayımını, saygı görmesi gerektiği kuralını fark etmiş, bunların güncel sorunları ve baş etme stratejileriyle ilişkilerini kavramıştır. Ayrıca kişiler arası ilişkilerde hassasiyetinin yüksek olduğu konulardaki toleransı artmış, saldırgan davranışlar yerine kendini ben diliyle ortaya koymaya başlamıştır. Müdahalelerin sonucunda Sürekli Öfke ve Öfke İfade Tarzı Ölçekleri ’ne göre danışanın sürekli öfkesinde, öfkesini uygun olmayan biçimde ortaya koymasında ve bastırmasında azalma, öfkesini kontrol etmesinde artış gözlenmiştir. Literatürde öfke tedavisinde BDT’nin etkisine işaret eden çalışmalarla tutarlı şekilde, bu vakada kullanılan BDT tekniklerinin etkili olduğu gözlemlenmiştir.
The Eclosion of Forest and Tree Health Stakeholdership
Authors: Dandy Norman , Porth Emily F.
Published: February 2021

The anthropogenic environmental change characteristic of the Anthropocene generates numerous threats and opportunities for the non-human beings who are intrinsic to forest and tree health. There are profound consequences for both humans and non-humans as a result of natural ecosystem disturbances, such as forest fires or invasive insects, and their accompanying environmental management responses. However, the consequences for non-humans as a result of either disturbance or management receive virtually no attention within environmental policy and practice. In this paper we argue for the growth and transformation – the ‘eclosion’ – of the ‘stakeholder’ concept so as to provide a pragmatic basis for greater attentiveness to, and comprehension of, non-human interest. We explore the implications and feasibility of this, describing particular approaches to stakeholder analysis and representation that emanate from research methods including multispecies ethnography and studies in ‘new animism’, that can effectively enable non-human ‘voices’ to be heard and taken more seriously. We conclude there are solid methodological and conceptual foundations on which to build an effective understanding of non-human stake-holdership, particularly in the area of forest and tree health.
STUDY OF GOLD EXTRACTION FROM STALE TAILINGS BY AGITATION LEACHING
Authors: Altayeva A. , Surimbayev B. N. , Bolotova L. S. , Bagasharova Zh. Т. , Akilbekova Sh. K.
Published: February 2021

The object of research is technogenic mineral formations-tailings of the Bestube processing plant located within the Bestube gold field. Analytical and technological studies of stale tailings have been carried out. According to the results of analytical studies, the material composition of stale tails was established. The average gold content in stale tailings according to assay analyses is 0.565 g/t, silver 1.56 g/t. The tailings belong to the category of poor sulfide, oxidized raw materials. The main industrially valuable component in the tailings is gold, silver has a subordinate value, and other metals are not of industrial value. Mineralogical analysis established that stale tails are represented by quartz, muscovite, clinochlore, albite, dolomite. Studies were conducted on agitation leaching of stale tailings of the initial size (64.08% of the class –0.074 mm) and after additional grinding to the size of 90% of the class –0.074 mm. Reducing the size contributes to the dissolution of gold from the tailings: at the initial size, 66.28% of gold is dissolved, after regrinding the degree of dissolution of gold from the tailings increases to 87.23%. The results of research on agitation leaching of gold have shown a high efficiency of hydrometallurgical technology for processing stale tailings of a processing plant.
TECHNOLOGY OF BOVINE LEUKEMIA VIRUS GENODIAGNOSTICS IN CATTLE, IN PRODUCED RAW MATERIALS AND PRODUCTS
Authors: Vafin R. R. , Gilmanov Kh. Kh. , Galstyan A. G. , Pryanichnikova N. S. , Bigaeva A. V. , Lazareva E. G. , Kazakova V. S.
Published: February 2021

The most important task of the dairy cattle industry is to obtain high quality raw milk. To achieve it, a set of measures is required, including aimed at increasing the biological safety of produced raw materials. The aim of the study was to create a scientific and methodological basis for the Bovine leukemia virus (BLV) gene diagnostics in a combined format of pathogen indication and identification. This required updating the strategy of BLV PCR-RFLP genotyping, consistent with its phylogenetic classification, taking into account the growing knowledge about the genetic diversity of 11 genotypes of the studied viral pathogen. When staging nested PCR, oligonucleotide primers were used, which initiate at the final stage of the reaction the production of a 444 bp env-gene fragment of the pathogen. Five restriction endonucleases were used in PCR-RFLP BLV genotyping of: PvuII, SspI, AsuHPI, HaeIII, and BstX2I. As a result of verification of the developed Bovine leukemia virus method for gene identification with an updated genotyping strategy, a technical result was obtained, expressed in the ability to identify all 11 BLV genotypes discovered to date by interpreting the generated 58 genotype-associated combinations of PCR-RFLP profiles.
REAL-TIME PCR TECHNOLOGY FOR CATTLE GENOTYPING BY A AND B KAPPA-CASEIN GENE ALLELES
Authors: Vafin R. R. , Gilmanov Kh. Kh.
Published: February 2021

The main goal of the study was to develop and test an effective technology for cattle genotyping by the CSN3 gene based on real-time PCR with hybridization-fluorescence detection. There was developed a method for real-time PCR for cattle genotyping by A and B alleles of the CSN3 gene in the format of hybridization-fluorescence detection, involving the use of two 5/-fluorescence-labeled forward allele-specific primers, one reverse common primer, and one anti-primer labeled with a fluorescence quencher at the 3/-end of the oligonucleotide. As a result of practical studies aimed at testing the developed method, we obtained the technical result provided by the proposed technology, expressed in the effective identification of the desired genotypes due to correct interpretation of these curves of increasing fluorescence intensity, the results reliability of which was also confirmed by the well-known PCR-RFLP analysis technique for Bos taurus genotyping for similar allelic variants of the kappa-casein gene.
THE CONTENT AND DISTRIBUTION OF TRACE ELEMENTS IN SOILS DURING THE DEVELOPMENT OF OIL FIELDS IN THE REPUBLIC OF KALMYKIA
Authors: Yessenamanova M. S. , Davaeva Ts. D. , Sangadzhieva L. Kh. , Tsombueva B. V. , Sangadzhieva O. S. , Yessenamanova Zh. S. , Tlepbergenova А. Е.
Published: February 2021

The article presents the results of chemical analysis soils of drilling sites of the Sostinsky and Mezhozerny oil fields of the Republic of Kalmykia. The content of sodium ions is more than 2 times higher in both deposits. At the same time, the content of chlorides in some areas of the Mezhozerny field reaches its maximum. As a result, the soils are highly saline in terms of the degree of salinity and are mainly chloride-sulfate-sodium in terms of the type of salinity. In oil fields, oil spills lead to the accumulation of organic carbon many times, with the total content of organic matter exceeding up to 5 times. The increase in the content of petroleum products is greatest in water discharge and wellheads. Studies on the content of heavy metals in the soils of oil fields showed that the average content of elements does not exceed the maximum permissible concentration of substances. At the same time, the content of most heavy metals exceeds the background ones, for example, lead, cadmium up to 2 times, strontium up to 8 times, mercury up to 6-12 times. In comparison with the clarke of the lithosphere (according to Vinogradov), an ecological-geochemical specialization in cadmium is noted. In the soils of the Sostinsky deposit, in the series of distribution of heavy metals, the maximum value is typical for cadmium, and in the Mezhozernoye deposit for mercury. At the Sostinskoye deposit, higher than the background is characteristic of such elements as: lead, vanadium, copper, strontium, and at the Mezhozernoye deposit, the excess of the background is achieved for such elements as: cadmium, zinc, lead, vanadium, copper, chromium, strontium.
MODIFIED SORBENTS AND THEIR APPLICATION FOR EXTRACTION OF METAL IONS
Authors: Murzakassymova N. C. , Bektenov N. A. , Gavrilenko M. A.
Published: February 2021

The data on accumulated mining waste in the territory of Kazakhstan are presented. Their processing has become very important in our time. The structure of surface-modified carbon materials with a grafted layer is given. New modified carbon sorbents were obtained, oleum was used as a modifying agent. It was revealed that the capacitive characteristics of the modified sorbent are significantly higher than that of the original one, which will make it possible to more efficiently extract the metal ion from wastewater and technogenic formations. Sorption is an effective method of extracting valuable components from wastewater and man-made formations. This method allows you to recover valuable substances with a high degree of wastewater treatment, which can be purified to the maximum permissible concentration of pollutants and then used in technological processes or in recycling water supply systems. Processing involves ores characterized by a low content of valuable components, fine dissemination and similar technological properties of minerals. The existing technologies for the development of minerals make it possible to use only a small part of the valuable mineral mass extracted from the subsoil, and the rest forms waste, which, as it accumulates and is stored, becomes one of the most significant factors of anthropogenic changes in the environment.
Mixed-Methods Study on Caregiver Strain, Quality of Life, and Perceived Health
Authors: Di Lorito Claudio , Bosco Alessandro , Godfrey Maureen , Dunlop Marianne , Lock Juliette , Pollock Kristian , Harwood Rowan H. , van der Wardt Veronika
Published: February 2021

Background: Caring for someone with dementia is associated with negative and positive experiences. There is little evidence based on large datasets. Objective: To present data around the experience of caring for someone with dementia, to identify support (emotional and practical) needs, and inform future service provision. Methods: A mixed-methods study embedded in the Promoting Activity, Independence and Stability in Early Dementia (PrAISED) Randomized Controlled Trial. We administered questionnaires on strain, quality of life (QoL), and perceived health to 301 caregivers and assessment of cognitive performance, depression, anxiety, and disability in activities of daily living to 301 participants with dementia. Data were analyzed through descriptive and modelling statistics. A subsample of 20 patient-caregiver dyads were qualitatively interviewed. Data around caregivers’ experience of providing care were extrapolated and analyzed through inductive thematic analysis. Results: There were significant negative associations between caregiver strain and QoL (p < 0.01) and between caregiver age and QoL (p < 0.01), and significant positive associations between caregiver strain and disability (p < 0.01), cognitive impairment (p < 0.01), depression (p < 0.05), and anxiety of the person with dementia (p < 0.05). Older caregivers reported a lack of support, reinforced by their reluctance to seek help. All caregivers reported contradictory emotions associated with caring and accumulation of strain over time. Conclusion: While there is recognition that it is essential to support caregivers, dedicated intervention programs, and support strategies to respond to the needs of older caregivers are still needed.
Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein
Authors: Quint Wim Hendricus , Matečko-Burmann Irena , Schilcher Irene , Löffler Tina , Schöll Michael , Burmann Björn Marcus , Vogels Thomas
Published: February 2021

Background: Alzheimer’s disease (AD) and other tauopathies are neurodegenerative disorders characterized by cellular accumulation of aggregated tau protein. Tau pathology within these disorders is accompanied by chronic neuroinflammation, such as activation of the classical complement pathway by complement initiation factor C1q. Additionally, about half of the AD cases present with inclusions composed of aggregated alpha-synuclein called Lewy bodies. Lewy bodies in disorders such as Parkinson’s disease and Lewy body dementia also frequently occur together with tau pathology. Objective: Immunotherapy is currently the most promising treatment strategy for tauopathies. However, the presence of multiple pathological processes within tauopathies makes it desirable to simultaneously target more than one disease pathway. Methods: Herein, we have developed three bispecific antibodies based on published antibody binding region sequences. One bispecific antibody binds to tau plus alpha-synuclein and two bispecific antibodies bind to tau plus C1q. Results: Affinity of the bispecific antibodies to their targets compared to their monospecific counterparts ranged from nearly identical to one order of magnitude lower. All bispecific antibodies retained binding to aggregated protein in patient-derived brain sections. The bispecific antibodies also retained their ability to inhibit aggregation of recombinant tau, regardless of whether the tau binding sites were in IgG or scFv format. Mono- and bispecific antibodies inhibited cellular seeding induced by AD-derived pathological tau with similar efficacy. Finally, both Tau-C1q bispecific antibodies completely inhibited the classical complement pathway. Conclusion: Bispecific antibodies that bind to multiple pathological targets may therefore present a promising approach to treat tauopathies and other neurodegenerative disorders.
Blinded Clinical Evaluation for Dementia of Alzheimer’s Type Classification Using FDG-PET: A Comparison Between Feature-Engineered and Non-Feature-Engineered Machine Learning Methods
Authors: Ma Da , Yee Evangeline , Stocks Jane K. , Jenkins Lisanne M. , Popuri Karteek , Chausse Guillaume , Wang Lei , Probst Stephan , Beg Mirza Faisal
Published: February 2021

Background: Advanced machine learning methods can aid in the identification of dementia risk using neuroimaging-derived features including FDG-PET. However, to enable the translation of these methods and test their usefulness in clinical practice, it is crucial to conduct independent validation on real clinical samples, which has yet to be properly delineated in the current literature. Objective: In this paper, we present our efforts to enable such clinical translational through the evaluation and comparison of two machine-learning methods for discrimination between dementia of Alzheimer’s type (DAT) and Non-DAT controls. Methods: FDG-PET-based dementia scores were generated on an independent clinical sample whose clinical diagnosis was blinded to the algorithm designers. A feature-engineered approach (multi-kernel probability classifier) and a non-feature-engineered approach (3D convolutional neural network) were analyzed. Both classifiers were pre-trained on cognitively normal subjects as well as subjects with DAT. These two methods provided a probabilistic dementia score for this previously unseen clinical data. Performance of the algorithms were compared against ground-truth dementia rating assessed by experienced nuclear physicians. Results: Blinded clinical evaluation on both classifiers showed good separation between the cognitively normal subjects and the patients diagnosed with DAT. The non-feature-engineered dementia score showed higher sensitivity among subjects whose diagnosis was in agreement between the machine-learning models, while the feature-engineered approach showed higher specificity in non-consensus cases. Conclusion: In this study, we demonstrated blinded evaluation using data from an independent clinical sample for assessing the performance in DAT classification models in a clinical setting. Our results showed good generalizability for two machine-learning approaches, marking an important step for the translation of pre-trained machine-learning models into clinical practice.
A new magnetic modeling method for magnetic levitation rotary table
Authors: Gong Yongxing , Xu Fengqiu , Xu Xianze , Zhang Kaiyang
Published: February 2021

Precision machining fields require the worktable to have a large-scale multi-degree-of-freedom motion capability. In order to provide a more accurate magnetic model for the control strategy decoupling process and the size parameter optimization design process of the maglev rotary table. This paper proposes a new magnetic modeling method based on the Two-Dimensional Harmonic method. Different from the existing harmonic method, this method simultaneously considers the tangential and radial magnetic field changes of circumferential magnetic array. And it eliminates the edge effect of the magnetic flux density distribution in the radial aperiodic direction. The magnetic force and torque are solved by the Lorenz integral formula and the Gaussian quadrature method. In order to verify the accuracy of the TDH method, the boundary element software RadiaTM is used for simulation, and a prototype is made for measurement. The experimental results shown that this method reduced the maximum error of the radial edge magnetic field from 104.19% to 3.29%. And it improved the calculation accuracy of magnetic force and torque by 60.74% and 84.39% respectively. This method does not rely on special example, and is beneficial to cross-platform applications. It is more suitable for realizing the magnetic modeling of the maglev rotary table with both rotational motion and large-stroke translational motion.
Flavonols composition of Ribes nigrum L. juices and their impact on spasmolytic activity
Authors: Miladinović Bojana , Branković Suzana , Živanović Slavoljub , Kostić Milica , Šavikin Katarina , Ðorđević Boban , Stojanović Dušica , Milutinović Milica , Kitić Nemanja , Kitić Dušanka
Published: February 2021

BACKGROUND:

Black currants are berries that attract attention due to the beneficial effects they possess. They are proven to be good antioxidants, anticancerogenic, cardio- and neuroprotective agents.

OBJECTIVE:

The main objective of this research was to evaluate the differences in the flavonols composition, antioxidant and spasmolytic activity of juices obtained from four different black currant cultivars – Triton, Tenah, Ben Sarek, and Ometa, grown over a 4-year long period on the territory of Serbia.

METHODS:

The qualitative and quantitative determination of black currants juices flavonols was performed using the HPLC. The antioxidative activity was carried out in DPPH and β-carotene systems. The study examined the impact of the main black currants flavonols and black currants juices on the spontaneous, KCl, and acetylcholine-induced ileum smooth muscle contractions.

RESULTS:

The dominant flavonol in juices of the four different black currant cultivars was myricetin, with its highest content obtained from the 2015 Triton juice (820.1±34.7 μg g–1). Quercetin was the second in abundance and the lowest yields were observed in kaempferol.

CONCLUSION:

The investigated black currant cultivars were proven to be good sources of flavonols and potential antioxidants with the significant spasmolytic activity that could be successfully used in treating gastrointestinal disorders.