bluuebunny/crossref_metadata_2025 huggingface dataset:
Revisited the potential risks of carcinogenicity of phototherapy in patients with psoriasis
Authors: Kubanov A. A. , Zhilova M. B.
Published: February 2022

The article presents published data on the assessment of the risk of cancerogenicity of multiple courses of phototherapy methods such as PUVA therapy and UVB-311 in psoriatic patients. The authors analyzed the incidence of malignant skin neoplasms (squamous cell carcinoma, basal cell carcinoma, malignant skin melanoma) among psoriatic patients from different population groups taking into account the cumulative radiation doses and number of procedures.
Local treatment of chloasma in pregnant women
Authors: Shperling N. V. , Vengerovsky A. I. , Shperling I. A. , Romanova E. V.
Published: February 2022

Goal. To assess the efficacy and safety of Azelic (15% gel of azelaic acid for topical administration) for the treatment of chloasma in pregnant women. Materials and methods. The study involved 28 pregnant women aged 18-36 (mean age: 24.7) with a normal course of pregnancy. The patients consulted a doctor in the spring, summer or fall complaining of focal skin hyperpigmentation on the face, chin and chest area. Ten patients (35.7%) developed hyperpigmentation prior to their pregnancy and 18 women (64.3%) - during the pregnancy. As of the consultation date, the pregnancy terms in all of the patients were 18-20 weeks. Chloasma was diagnosed by using dermatoscopy and skin examination with the Wood’s lamp. The patients were informed about the content and procedure of the study and gave their consent to take part in the study. Thin layers of Azelic (15% gel of azelaic acid for topical administration) were applied to the hyperpigmented skin of the patients and gently rubbed twice a day (in the morning and evening) as topical treatment for four months. The treatment results were assessed taking into consideration the patient’s subjective assessment, study group structure depending on the clinical efficacy, percentage of adverse events, and survey results based on the Dermatology Life Quality Index questionnaire. To reveal any potential general toxicological effects of the treatment, hepatic samples, total blood count and coagulogram results were analyzed as a part of obstetrical and gynecologic care for pregnant women. Key findings. Positive dynamics of the following characteristics was revealed: subjective assessment of treatment results by the patients, clinical efficacy of treatment and life quality index. Therapeutic results were observed as early as after one month but not later than three months after the treatment began. The therapeutic efficacy was recorded in 92.9-96.4% of all cases after four months of treatment: pigment spots disappeared or became paler, and their dimensions and their contrast as compared to the healthy skin reduced, the skin texture and life quality improved (the Dermatology Life Quality Index reduced from 15.5 ± 1.8 to 6.7 ± 0.5 points against the background of the treatment efficacy: from severe to moderate impact of the disease on the patient’s life, respectively). Five women (17.9%) developed erythema and burning sensations in the drug application site within the first two weeks immediately after the gel application (one of the patients had the same symptoms for six weeks of the treatment); the symptoms were weak and transient and did not require any additional treatment. Hepatic samples, total blood count and coagulogram results were within physiological standards during the treatment. Conclusion. Topical application of Azelic (15% gel of azelaic acid for topical administration) twice a day for four months is an efficient and safe method to treat chloasma in pregnant women.
Update on topical photodynamic therapy for skin cancer
Authors: Morton C. A. , Szeimies R. -M. , Braathen L. R.
Published: February 2022

Topical photodynamic therapy has become an established therapy option for superficial non-melanoma skin cancers with a substantial evidence base. In this update the increased choice in photosensitizers and light sources are reviewed as well as novel protocols to move beyond lesional treatment and address field therapy. Daylight PDT is emerging as an alternative to conventional office/hospital-based PDT that offers the advantage of much reduced pain. Although most studies have assessed efficacy of PDT in immune-competent patients, there is accumulating evidence for topical PDT being considered an option to assist in reducing the skin cancer burden in organ transplant recipients. The fluorescence associated with photosensitizer application can help delineate lesions prior to full treatment illumination and offers a useful adjunct to treatment in patients where diagnostic uncertainty or poor lesion outline complicates clinical care. PDT may also offer significant benefit in delaying/preventing new cancer development and combined with its recognized photo-rejuvenating effects, is emerging as an effective therapy capable of clearing certain superficial skin cancers, potentially preventing new lesions as well as facilitating photo-rejuvenating effects in treated areas.
Neurotrophins and neuropeptides as inflammatory mediators in case of chronic dermatosis
Authors: Kubanova A. A. , Smolyannikova V. A. , Chikin V. V. , Karamova A. E.
Published: February 2022

This literature review examines the role of neurotrophins and neuropeptides for the development of skin inflammatory reactions in case of chronic inflammatory dermatoses. The article describes inflammatory effects of neurotrophin, a nerve growth factor, neuropeptide substance P and calcitonin gene-related peptide. Factors affecting the condition of skin innervation and development of inflammation - neurotrophin, a nerve growth factor, amphiregulin, an epidermal growth factor, and semaphorin 3A, a nerve repulsion factor - were examined. Searching for and administering antagonists of proinflammatory effects of neuropeptides, neurotrophins and epidermal growth factor can become new approaches to the treatment of chronic inflammatory dermatoses.
Prevalence of genetic risk factors of psoriasis among the population of the Russian Federation
Authors: Kubanov A. A. , Kubanova A. A. , Karamova A. E. , Mineyeva A. A.
Published: February 2022

Goal. To assess the prevalence of polymorphisms of genes of the predisposition to psoriasis among the population of the Russian Federation. Materials and methods. The authors examined 546 psoriasis patients and 206 healthy people. The polymorphism of the following genes was assessed: genes encoding proteins of the signaling pathway of the nuclear transcription factor kappa-B - NF-κΒ (NFKBI, TRAF3IP2, TNFAIP3, REL, TYK2, TNIP1, IL-28RA) responsible for congenital immunity; genes participating in the IL-23 signaling pathway responsible for adaptive immunity (IL-23R, IL-12B); genes participating in the presentation of the antigen (ERAP1); genes responsible for skin barrier dysfunction (SERPINB8 ZNF313, ZNF816A). Peripheral blood leucocytes served as the DNA source. Polymorphisms of IL-23R, IL-28RA, SERPINB8, TRAF3IP2, TNFAIP3, REL, ZNF313, IL-12B, TNIP1, ZNF816A, ERAP1 genes were determined by the real-time PCR method; polymorphisms of NFKBI, TYK2 genes were determined by the RFLP assay (Restriction Fragment Length Polymorphism). Results. In psoriasis patients in the Russian Federation, statistically significant differences in the distribution of allele frequencies were determined for IL-23R-G/G, IL-23R-A/A, TRAF3IP2-A/A, TRAF3IP2-G/G, TNFAIP3-A/C, TNFAIP3-A/A, ZNF313-C/C, TYK2-T/T, TYK2-T/G, TNIP1-G/G, TNIP1-A/G, REL-A/A, ERAP1-G/G genotypes.
Inflammation and itching in patients suffering from atopic dermatitis and psoriasis. Assessment of the expression of neurotrophins аnd neuropeptides
Authors: Smolyannikova V. A. , Kubanova A. A. , Chikin V. V. , Karamova A. E.
Published: February 2022

Goal. To assess the expression of neurotrophin, a nerve growth factor, amphiregulin, an epidermal growth factor, semaphorin 3A, a nerve repulsion factor, and PGP9.5 protein, a nerve fiber marker, in the skin of patients suffering from atopic dermatitis and psoriasis. Materials and methods. The study involved 30 patients suffering from atopic dermatitis and 30 patients suffering from psoriasis vulgaris. The disease severity was assessed by SCORAD and PASI. The extent of itching was assessed by the visual analogue scale. The expression of amphiregulin, semaphorin 3A (a nerve growth factor) and PGP9.5 protein (a nerve fiber marker) in the skin of patients was assessed by the indirect immunofluorescence method. Quantitative parameters of their expression were assessed by using the basic pack of the Olympus Fluoview software, Ver. 1.7b. Results. Increased epidermal innervation was revealed in the patients suffering from atopic dermatitis and psoriasis, which demonstrates an increased skin production of anti-inflammatory neuropeptides and reduced itching sensitivity threshold. A positive correlation between the itching extent and skin expression of neurotrophin (a nerve growth factor) was revealed in the patients with atopic dermatitis. In patients with severe psoriasis, an increased skin expression of amphiregulin, an epidermal growth factor, was discovered. Conclusion. These data demonstrate a pathogenic value of neurotrophin, a nerve growth factor, for the development of itching in patients with atopic dermatitis and amphiregulin in case of psoriasis vulgaris.
Photodynamic therapy with methyl aminolevulinate in the treatment of basal cell carcinoma
Authors: Kubanov A. A. , Kondrakhina I. N. , Gribanov N. V.
Published: February 2022

The article presents the results of the studies on the effectiveness of treatment basal cell carcinoma of the skin with photodynamic therapy with 5-aminolevulinic acid and methyl aminolevulinate. The results of the comparing trials between photodynamic therapy with methyl aminolevulinate and different other treatment modalities are presented.
Clinical efficacy of the rotation of phototherapy methods (PUVA therapy and mid-wavelength ultraviolet therapy (311 nm)) in patients with moderate to severe forms of psoriasis
Authors: Zhilova M. B. , Chikin V. V.
Published: February 2022

Goal. To assess the therapeutic efficacy of the rotation of mid-wavelength ultraviolet therapy (311 nm) and PUVA therapy in patients with moderate to severe forms of psoriasis, and to assess the efficacy of mid-wavelength ultraviolet therapy (311 nm) in a multiple-course therapy. Materials and methods. The study involved 66 patients with moderate to severe forms of psoriasis who received multiple courses of treatment by methods of the PUVA therapy and narrowband mid-wavelength phototherapy (311 nm). The patients were divided into three groups: Group 1 (n = 20) - patients who received treatment in the form of mid-wavelength ultraviolet therapy (311 nm) after multiple courses of PUVA therapy; Group 2 (n = 26) - patients who received only multiple courses of PUVA therapy; Group 3 (n = 20) - patients who received only multiple courses of mid-wavelength ultraviolet therapy (311 nm). Results. The authors determined high efficacy (82.8%) of mid-wavelength ultraviolet therapy (311 nm) in patients with moderate to severe forms of psoriasis vulgaris who had previously received multiple courses of PUVA therapy. After multiple courses of long-term treatment by mid-wavelength ultraviolet therapy (311 nm), patients with moderate to severe forms of psoriasis had high efficacy of such multiple courses of treatment (85.78%). Conclusion. Patients with moderate to severe forms of psoriasis who had previously received multiple courses of PUVA therapy can be switched to mid-wavelength ultraviolet therapy (311 nm) with the maintenance of high efficacy of such treatment. The authors observed the absence of any adaptation to the spectral range of mid-wavelength ultraviolet therapy (311 nm) in case of multiple courses of treatment.
Squamous cell carcinoma in a psoriasis patient after multiple courses of phototherapy
Authors: Zhilova M. B. , Smolyannikova V. A.
Published: February 2022

The authors present a clinical case study of squamous cell carcinoma in a psoriasis patient after 24 courses of phototherapy (22 courses of PUVA therapy and two courses of mid-wavelength ultraviolet therapy (311 nm)). The malignant neoplasm developed against the background of signs of a chronic photodamage of the skin: lentigo, actinic elastosis, diffuse hyperpigmentation, spotty skin pigmentation.
Current standards for diagnosis of syphilis: comparing the russian and foreign guidelines (part I)
Authors: Krasnoselskikh T. V. , Sokolovskiy E. V.
Published: February 2022

Despite the abundance of existing laboratory methods the diagnosis of syphilis still faces many challenges. Though direct detection of T. pallidum plays an important role in early manifest forms of the disease, serological tests remain the mainstay of diagnosis. Traditional syphilis screening algorithm based on nontreponemal tests with subsequent confirmation using treponemal tests is a standard worldwide. Recently, the ability to automate the treponemal tests promotes the increasingly widespread implementation of reverse algorithm when these tests are used for syphilis screening. None of the current serological algorithms are able to reliably differentiate between active and previously treated syphilis, which causes uncertainty in the management of patients. There is no «gold standard» for the diagnosis of neurosyphilis, ocular, auricular and visceral syphilis. The interpretation of serological tests in children born to seropositive mothers is also complicated. Diagnosis of congenital syphilis in newborns and, consequently, the prescription of antibiotic therapy often depends on assessment of the adequacy of maternal treatment during pregnancy, which leads to subjective decisions. This article provides a comparative analysis of the «Federal guidelines for the management of patients with syphilis» and their foreign analogues, discusses significant peculiarities of these guidelines and reviews current concerns and controversies in syphilis diagnosis.
Risk factors causing the development of infection and inflammation of the lower urinary tract
Authors: Kamalov A. A. , Khodyreva L. A. , Dudareva A. A. , Nizov A. N.
Published: February 2022

Persistence as well as high survival rate and resistance of microorganisms belong to the key reasons promoting symptoms of lower urinary tract diseases. They can stay active for a long time and can substantially deteriorate the life quality of patients suffering from chronic infections and inflammations in the wall of the urinary bladder even after the eradication of the pathogen. Recent studies in the field of clinical microbiology reflect serious qualitative and quantitative changes in the infection incidence structure, which is mainly related to changes in the bacterial pathogenicity. Pathogenicity island genes control the synthesis of different adhesins, invasins, hemolysins and toxins (hemolysin, cytotoxic necrotizing factor type 1, etc.) as well as iron ion absorption system, which are essential for the pathogen propagation and activity in tissues. The determination of genetic determinants will provide a new insight into the bacterial evolution process and will help to understand the reason of prompt formation and propagation of virulent strains as well as fast development of the infection and inflammation in the lower urinary tract, which may explain different severity of the pathology and symptoms of the lower urinary tract.
Steroidophobia in dermatology - contemporary problem of the past
Authors: Dvoryankova E. V.
Published: February 2022

Topical steroids are the first-line drugs for the treatment of the majority of dermatological diseases. Currently, however, often we have to deal with steroidophobia both among patients and doctors. The problem has been actively studied since steroidophobia can significantly reduce the quality of the treatment. At the same time, with the use of modern topical steroids, such as Advantan, steroidophobia has no grounds due to the high level of safety under normal use of drugs.
Prevalence of localized scleroderma in the Krasnodar territory
Authors: Tlish M. M. , Sorokina N. V.
Published: February 2022

The authors conducted a study of particular features of the course of localized scleroderma in the south of Russia (Krasnodar territory). 65 case histories were analyzed. Women suffered from the disease 2.8 times more often than men; one half of the sample (55.4%) included patients aged 35-55; the disease duration of over a year prevailed (69.8%); the disease occurred against the background of an endocrine pathology in one third of all cases; one third of all women developed the disease during the postmenopausal period. Plaque scleroderma (56.9%), white spot disease (von Zumbusch psoriasis) (16.9%) and idiopathic atrophoderma of Pasini and Pierini (12.3%) belonged to the key clinical forms. The average number of lesions was 2.4 ± 1.2 while almost a half of the patients (47.7%) had three or more lesions. The clinical manifestations localized mostly on the back (46.5%) and stomach (34.9%).
Photodynamic therapy of the surface form of basalioma and actinic keratosis with the topical administration of methyl aminolevulinate
Authors: Kubanova A. A. , Kubanov A. A. , Kondrakhina I. N. , Gribanov N. V.
Published: February 2022

Goal. To assess the efficacy of the photodynamic therapy with the external use of methyl aminolevulinate as a photosensitizer with further irradiation with visible red light with the wavelength of 630 nm in the treatment of patients suffering from a surface form of basalioma and actinic keratosis. Materials and methods. The study involved 28 patients diagnosed with the surface form of basalioma and 34 patients diagnosed with actinic keratosis. They underwent treatment by the photodynamic therapy method using a LED lamp radiating visible red light with the wavelength of 630 nm, with the total dose of irradiation equal to 37 J/cm2. All patients also underwent a confocal in vivo laser scanning microscopy of lesions at the baseline and after 7, 30, 90 and 180 days of treatment. Results. Absolute regression of abnormal lesions was observed in 25 (91%) patients diagnosed with the surface form of basalioma and 30 (88.9%) patients diagnosed with actinic keratosis after 30 days of treatment. No signs of the diseases were revealed in these patients after examination by the method of confocal in vivo laser scanning microscopy. Conclusion. The photodynamic therapy with the local administration of methyl aminolevulinate with further irradiation with visible red light with the wavelength of 630 nm is an efficient method of treatment of the surface form of basalioma and actinic keratosis.
Therapy of acne: azelaic acid and basic care
Authors: Monakhov K. N. , Dombrovskaya D. K.
Published: February 2022

The review covers current concepts of the pathogenesis of acne. It presents the data of international and Russian clinical studies conducted to assess the efficacy and safety of drugs comprising 15% azelaic acid and used for the treatment of acne. The authors describe mechanisms of the effect of azelaic acid on major stages of the pathogenesis of acne. They substantiate the need in basic care in the treatment of acne by the example of products of the JOYSKIN line. The authors discuss the effect of different components of skin care products on the acne-prone skin.
An experience of using methylprednisolone aceponate in the therapy of lupus erythematosus tumidus
Authors: Kotrekhova L. P. , Vashkevich A. A.
Published: February 2022

Lupus erythematosus tumidus is a rare skin form of lupus erythematosus. About 250 cases of lupus erythematosus tumidus have been described in the world by now. A specific clinical sign of this dermatosis is the appearance of annular or arcuate urticaria-like rash. As a rule, the appearance of the rash is preceded by ultraviolet irradiation. The administration of glucocorticosteroid drugs of local action belonging to classes of potent and very potent steroids is the first-line therapy for lupus erythematosus tumidus. The authors describe a case of the successful treatment of lupus erythematosus tumidus with methylprednisolone aceponate (Advantan ointment) in a female patient aged 56.
Syphilitic infection and pathological pregnancy, childbirth and the changes of the placenta
Authors: Matyskina N. V. , Taranushenko T. E. , Prokhorenkov V. I.
Published: February 2022

It is now known that one of the main causes of pathology of pregnancy, childbirth and placenta, is infection. The purpose of the study. To reveal the peculiarities of pregnancy and delivery, as well as histological changes of placenta in syphilitic infection, depending on the time of detection of the disease. The materials and methods of research. Under the supervision of 114 women with confirmed syphilis infection. In accordance with the intended purpose of the study three groups of women with syphilitic infection. Group I included 42 women who are diagnosed with syphilis installed for the first time in this period of pregnancy or nursing home. II group consisted of 34 women who have had syphilis prior to the present pregnancy had been trained in specific therapies, but during this pregnancy had a positive DAC. In the third group consisted of 38 women who had syphilis and received a course of specific therapy prior to the present pregnancy, with a negative DAC during this pregnancy. The control group included 30 women without a history of syphilis. Results and discussion. We found a significant increase in the overall frequency of complications in childbirth in women with syphilitic infection, the most common manifestation of the pathology of childbirth should be considered the changing nature of amniotic fluid and the need for manual examination of the uterine cavity. Degenerative changes in the form of petrification was absent in the control group and identified in women I-III bands 21.4-28.9 percent. Inflammatory changes of the placenta was detected with significantly higher frequency in group I. We found a significant prevalence of pathological changes in the stroma of the villi in placentas in groups I-III compared with the control. Conclusion. Leading macro- and microscopic pathological disorders of the placenta, concomitant syphilitic infection and emerging at 16-18 weeks of gestation and may be involved in the development of complications of pregnancy and childbirth.
Psoriasis and porphyria cutanea tarda, associated with chronic hepatitis C in HIV-infected patients (clinical observation)
Authors: Korotaeva I. A. , Sklyar L. F. , Simakova A. I. , Singur L. G. , Popov A. F.
Published: February 2022

The continued growth of HIV-infected patients is associated on the one hand, with increase of life expectancy because of antiretroviral therapy, and the other - with high incidence of new cases of HIV-infection. It is important to remember that almost every HIV-infected patient has concomitant disease. The presence of comorbidity increases days of hospitalization, disability, impedes rehabilitation and leads to polypharmacy. Moreover, polypharmacy, particularly in HIV-patients, contributes to a sharp increase of adverse local and systemic side effects of drugs. This article presents the clinical examples of skin diseases in patients with HIV-infection.
Kindler syndrome - a rare type of hereditary epidermolysis bullosa
Authors: Albanova V. I. , Smolyannikova V. A. , Golchenko V. A.
Published: February 2022

The Kindler syndrome is one of the types of hereditary epidermolysis bullosa with its onset related to mutations of the KIND1 gene. The authors describe a case of a family with three members suffering from this rare disease. All of these patients have typical clinical manifestations of the Kindler syndrome such as the formation of blisters on the skin and mucous membranes right after the birth, scarring with the formation of contractures, pseudosyndactyly, microstomia and ankyloglossia, progressive poikiloderma, photosensibility, affections of the gastrointestinal tract - dysphagia, esophagostenosis, stool disorders, dental pathology, phimosis vaginalis in women.
Широкое многообразие кератинов человека
Authors: Yunusbaeva M. M. , Yunusbaev B. B. , Valiev R. R. , Khammatova A. A. , Khusnutdinova E. K.
Published: February 2022

А review presents systematic data about the diversity of human keratins. The results of numerous studies concerning the structure and functions of keratins, their distribution in various cells and tissues were summarized. The role of these proteins in the development of human hereditary diseases, as well as modern approaches in use keratins in immunohistochemistry and perspectives of their further studies are discussed.
Progression of itching intensity and expression of growth factor proteins in skin of people suffering from atopic dermatitis under the influence of ultraviolet phototherapy
Authors: Kubanova A. A. , Kubanov A. A. , Chikin V. V. , Volnukhin V. A. , Smolyannikova V. A. , Nefedova M. A.
Published: February 2022

Study of progression of itching intensity and expression of growth factor proteins in skin of people suffering from atopic dermatitis under the influence of narrowband (311Nm) phototherapy. Material and methods. 30 patients with atopic dermatitis were treated by using narrowband (311Nm) phototherapy. SCORAD index was used to assess the severity of the clinical responses. Itching intensity was assessed using visual analogue scale. Expression of growth factor of nerves, semaphorine-3A, amphiregulin, and PGP9.5, a protein marker for nerve fibers, was investigated by means of indirect immunofluorescence. Results. Increased expression level of nerves growth factor, decreased expression level of semaphorine-3A, and increase in the number, average length and luminous intensity of PGP9.5+ -nerve fibers were found in the patients’ epidermis. Course of narrowband (311 Nm) phototherapy resulted in a decrease of the severity of the disease and itching intensity, and semaphorine-3A expression increase, reduction of number and average length of nerve fibers in the epidermis. A direct correlation relationship between the itching intensity and expression level of nerve growth factor, number and average length of PGP9.5+ -nerve fibers in the epidermis as well as an inverse correlation relationship between itching intensity and expression level of semaphorine-3A in the epidermis were found. Conclusion. Treating patients suffering from atopic dermatitis with narrowband (311 Nm) phototherapy leads to a decrease of the itching intensity associated with a decreased intensity of innervation of the epidermis. This decrease in course of phototherapy is facilitated by decrease of nerve growth factor expression level and increase of semaphorine-3A expression.
Guidelines for treatment of atopic dermatitis (atopic eczema) from American Academy of Dermatology, European Academy of Dermatology and Venereology and Russian Society of Dermatovenereologists and Cosmetologisis. Expert’s opinion
Authors: Samtzov A. V. , Sokolovsky E. V. , Araviiskaia E. A.
Published: February 2022

Atopic dermatitis (AD) is a common skin condition treated by dermatologists all over the world. Guidelines for management and treatment of AD have appeared in Europe, USA and Russia recently. the paper contains comparison of European, American and Russian guidelines. Definition of AD, epidemiology, pathophysiology of the disease, clinical features, diagnostic criteria, and risk factors are consistently matched. the analysis demonstrated that guidelines do not contain serious contradictions and principal differences thus stressing their supplementation of each other.
Modern concepts of skin dendritic cells
Authors: Antonova O. V. , Trofimov P. N. , Khairutdinov V. R. , Belousova I. E. , Samtsov A. V.
Published: February 2022

Based on the literature review this article is about the latest data of the classification and functions of dendritic cells in healthy skin and in disease.
Naftifine hydrochloride (NH) in the treatment of pityriasis versicolor
Authors: Kotrekhova L. P. , Vashkevich A. A. , Tsurupa E. N. , Reztsova P. A.
Published: February 2022

Introduction & objectives: The purpose of this study was to demonstrate the efficacy comparability of 1% NH lotion vs. of 1% NH cream (exoderil, Sandoz) in the treatment of pityriasis versicolor. Material & methods. 71 patients with pityriasis versicolor were randomly allocated either to receive NH lotion once daily (NH lotion group (п = 35, 38.6 years (95% CI [33,7, 43.5]) or NH cream once daily (NH cream group (п = 36, 40.8 years (95% CI [36,6, 45.0]) for 14 days. Mycological evaluations (microscopy and culture) were performed at weeks 2 and 3, inflammation symptoms evaluations were scored at day 3, weeks 2 and 3 after start of the therapy. Overall cure rates assessment included results of mycological, clinical outcomes and safety evaluation. Results. There was no difference between groups in mycological cure rates (94% vs 92%) and inflammation regression (97% vs 97%). Overall cure rate was 91% and 92% of patients in NH lotion and NH cream groups respectively (p = 0,97). Conclusion. 1% NH lotion and 1% NH cream are effective in the treatment of pityriasis versicolor.
Atopic dermatitis in children: prospects of using innovation products as an external therapy
Authors: Tlish M. M. , Gluzmin M. I. , Kartashevskaya M. I. , Psavok F. A.
Published: February 2022

Goal of the research: to determine the efficacy of a new line of Atopic cosmetic products for skin care in children suffering from atopic dermatitis. Materials and methods: The study involved three groups of 15 children aged 3-12 suffering from atopic dermatitis in each group. Subjects from Group 1 were treated with Atopic Soothing Cream, from Group 2 with Atopic Soothing Stick Cream and from Group 3 with Atopic Everyday Care Cream. Different inclusion and exclusion criteria were developed for each group, and the algorithm for the product application and efficacy criteria were determined. According to recommendations, Atopic Soothing Cream and Atopic Soothing Stick Cream were applied to clean and dry skin in the morning and in the evening for the study period of 14 days. The patients’ skin condition was assessed prior to the study and on Day 14 of the therapy; the assessment covered parameters necessary for calculating the SCORAD Index. Atopic Everyday Care Cream was applied to clean and dry skin in the morning and in the evening for 28 days. The patients’ skin condition was assessed prior to the study and on Days 14 and 28 of the therapy including the SCORAD Index and assessments of the skin hydration level of the epidermal corneous layer and transepidermal waster loss (TEWL) using the DermaLabCombo CORTEX device. According to the study results, the line of Atopic cosmetic products fully complies with the properties specified by the manufacturer, reliably improves the skin condition in children suffering from atopic dermatitis, has no irritant or sensitizing effect, and can be recommended for the complex treatment and rehabilitation of patients suffering from the pathology.
The course and treatment of atopic erythroderma Hill (case study)
Authors: Sokolova T. V. , Safonova L. A.
Published: February 2022

Relevance. Atopic erythroderma Hill (AEH) is a severe variant of the disease. Its occurrence depends on the examined patients and between 1.9% (young men of military age) to 42% (persons admitted to hospital). The treatment procedure is directly related to the presence of trigger factors, aggravating the disease. The purpose of this publication. To analyze the errors of physicians in the choice of Treatment for patients with AEH. Materials and methods. Use material during the examination and treatment of two patients with AEH aged 5 and 17 years in the allergological center of professor Ado A.D. The detailed analysis of the characteristics of AEH and reasons for the ineffectiveness of traditional treatment methods. Main results. Clinical, immunological, bacteriological methods have made it possible to identify trigger factors contributing to the transformation of the classical course of atopic dermatitis in AEH. Limiting their influence helped improve efficiency. Conclusion. The drug of choice for topical therapy AEH is the methylprednisolone aceponate + ceramides (Komfoderm K), which has a pronounced anti-inflammatory and moisturizing effect with the ability to handle up to 60% of the skin within 12 weeks.
Using clinical and diagnostic indices to assess the severity of pemphigus (a comparative analysis)
Authors: Kubanov A. A. , Abramova T. V.
Published: February 2022

The article discusses clinical indices suggested for the assessment of the severity of the course of autoimmune bullous dermatosis - pemphigus. These indices make it possible to assess the severity of the disease in view of the localization and prevalence of blisters and/or erosions and patient’s subjective sensations as well as efficacy of the therapy, and to compare the study results. In spite of the great number of indices suggested for the assessment of the severity of pemphigus, none of them are generally recognized. The following indices are currently considered as the best known and most convenient for application in clinical practice: Pemphigus Disease Area Index (PDAI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Vulgaris Activity Score (PVAS). A number of studies demonstrated mutual correlation among ABSIS, PDAI and PVAS. However, the group of patients under examination mainly comprised people suffering from light to moderate forms of pemphigus, which makes it difficult to interpret the results of comparative studies. It is expedient for leading dermatovenerologists to carry out clinical studies based on a large group of patients with pemphigus of different severity to elaborate a common tool to assess the severity of pemphigus in the Russian Federation to be recommended by the Russian Society of Dermatovenerologists.
Drug therapy of leprosy
Authors: Kubanov A. A. , Karamova A. E. , Vorontsova A. A. , Kalinina P. A.
Published: February 2022

Leprosy (Hansen’s disease) is a chronic granulomatous bacterial infection mainly affecting the skin and peripheral nervous system yet also involving other organs and systems as a result of a pathological process. The causative agent of leprosy - Mycobacterium leprae - is an obligate intracellular microorganism. Despite the removal of a threat of a leprosy epidemic, European countries still record outbreaks of the disease mainly among migrants coming from endemic areas. A golden standard of the treatment of leprosy is a WHO-recommended combined drug therapy comprising drugs such as dapsone, clofazimine and rifampicin. The article provides current data on the mechanisms of action, efficacy and safety of these drugs and their combined scheme of treatment obtained as a result of clinical trials. Moreover, it also reviews new regimens of the drug therapy of leprosy including those with the use of drugs from the group of fluoroquinols as well as immunotherapy of the disease.
100 years of the clinic and the 140th anniversary of the Department of skin and sexually transmitted diseases of Rostov state medical University
Authors: Kuzina Z. A. , Sidorenko O. A. , Anisimova L. A. , Opruzhenkova E. P. , Grebennikov V. A. , Temnikov V. E. , Starostenko V. V.
Published: February 2022

The article describes the stages of development and formation of the national dermatovenereology, history of one of the oldest department of skin and sexually transmitted diseases in Russia. Discusses national and global role of the P.V. Nikolsky, Z.N. Grjebine, N.A. Torsuev, L.M. Khasabov and other colleagues of clinic and chair in the learning and teaching of dermatology and venerology, their contribution to the fight against leprosy, skin and venereal diseases.
Selective intracellular inhibition of signalling pathways - new direction in systematic treatment of psoriasis patients
Authors: Bakulev A. L.
Published: February 2022

This article presents current data from publications on new direction in systematic treatment of patients with psoriasis with help of "small molecules" that act intracellularly, selectively inhibiting signaling pathways responsible for production of key pro- and anti-inflammatory mediators that play an important role in the pathophysiology of psoriasis. We discuss key issues that refer to immunopathogenesis of psoriasis, targeted influence of "small molecules" on key components of innate and adaptive immune system of patients psoriasis. This article presents results of the studies performed according to the evidence-based medicine approaches, on the efficiency and safety of apremilast - the first and only current selective inhibitor of intracellular phosphodiesterase 4 - for treating medium-severe and severe psoriasis, including patients with problematic localizations of dermatosis (psoriasis of scalp pilar part, palms, soles, nail plates), as well as in the long run. It is shown that continuous apremilast therapy for the term of 52-156 weeks was accompanied by a significant decrease in prevalence and severity of psoriasis. Adverse events were recorded rarely, they were mild, and frequency of serious adverse reactions was comparable to placebo.
15 year experience of tacrolimus application in medical practice
Authors: Kondratyeva Y. S. , Kokina O. A. , Vedler A. A.
Published: February 2022

The review presents modern literature data on the use of tacrolimus in medical practice. The results of national and international research on the effectiveness and safety of the drug at various dermatoses are presented.
On the 115th anniversary of the dermatovenereology department of the academician I.P. Pavlov First St. Petersburg state medical university (part I)
Authors: Krasnoselskikh T. V. , Sokolovskiy E. V.
Published: February 2022

The history of the Department of Dermatovenereology of the First St. Petersburg State Medical University from its foundation in 1901 till 1956 is traced in the article. These years of formation and development of the Department were associated with the activities of the outstanding dermatologists such as T.P. Pavlov, S.Ya. Kulnev, A.A. Sakhnovskaya, O.N. Podvysotskaya.
Actinic reticuloid. Diagnostics
Authors: Sokolovskiy E. V. , Micheev G. N. , Demidova E. I.
Published: February 2022

This article is about the case of actinic reticuloid - the rare dermatosis which clinical presentation is similar to atopic dermatitis, T-cell lymphoma. Good treatment effect was obtained by long cycles (2 cycles for 3 months) of hydroxychloroquine and sun protective therapy included sunscreens SPF 50, nicotinic acid, sun-safe clothes which blocked ultraviolet radiation without any glucocorticosteroid drugs and cytostatic treatment.
Lepra recurrent developed after termination of antileprotic therapy
Authors: Kubanov A. A. , Karamova A. E. , Semenova V. G. , Smoliannikova V. A. , Nefedova M. A.
Published: February 2022

Lepra is an infectious disease, granulomatosis caused by Mycobacterium leprae. It is characterized with prolonged latent period (from 3-5 years to several decades), low transmission, generally lesions of skin and peripheral nervous system. The recurrent of disease is possible after the termination of antileprotic therapy. A case report presented demonstrating the lepra recurrent in female patient 4 years after termination of therapy; that was conducted during 17 years and led to the regression of clinical symptoms and to negative results of bacterioscopic examination of nasal brushings and scratch samples from sites of former eruptions. This case should call attention of dermatologists and other physicians to the problem of leprosy recurrent diagnosis in previously observed and deregistered patients.
Efficacy of the combined therapy with etanercept and methotrexat at the female patient with generalized pustular psoriasis and arthritis psoriasis after the therapeutic failure of two the TNF-α receptor inhibitors. Case study
Authors: Vustina V. V. , Grigoriadi N. E. , Korotayeva T. V.
Published: February 2022

The article presents the clinical observation effectiveness of TNF-a inhibitor etanercept in patients with generalized pustular psoriasis and PsA, resistant to treatment by other drugs of this class. It presents the current recommendations for the management of patients with pustular psoriasis.
New opportunities in the therapy of steroid-specific dermatosis - combination of topical glucocorticosteroid with urinium
Authors: Filimonkova N. N. , Kolbina M. S.
Published: February 2022

External therapy with topical steroids is used for a long time. To date topical glucocorticosteroids (TGCS) are in the leading position in dermatology among all medicines for external therapy. TGCS as a powerful tool of pathogenic action can rapidly reduce or decrease inflammatory changes in the skin and eliminate subjective symptoms of dermatoses (itching, burning). their positive effect lead to the rehabilitation of working ability and daily living activity, positively affect the psychoemotional state and significantly improve the patient’s quality of life. Urea in dermatology has been used for a very long time, as it softens the skin, reduces its dryness and eliminates peeling. In recent decades interest in this compound has intensified after a formation of an idea about natural moisturizing factor (NMF) - a complex of substances (which includes urea) being a part of the intercellular matrix of the epidermis and capable of retaining the water in the epithelial layer of the skin necessary for its normal functioning. The article presents modern literature data on the reasoning of the inclusion of a combination of topical glucocorticosteroids with urea in a complex therapy of steroid-responsive dermatoses.
PATHOMIMIA IN CHILDREN
Authors: Tamrazova O. B.  , Gureeva M. A. 
Published: February 2022

The article is dedicated to the problem of children pathomimia. Autoaggressive injuries in pediatrics are very common; they have a variety of clinical manifestations and can be a symptom of severe mental disorders. The article describes in detail the mechanisms for the formation of autoaggressive behavior, provides a classification of psychodermatoses, and describes the clinical features of the course of pathomimia in childhood and adolescence. The authors focused on the frequently occurred forms of pathomimia, which are provoked by stress factors and are transient. An approach to the treatment of skin autolesions in children has been proved and it is noted that the general treatment of pathomimia will depend on the degree of severity and manifestations of mental illness, and external therapy of psychodermatoses will lead to accelerating the regeneration of the skin lesion as well as the preventing of secondary infection.
ASSOCIATED PATHOLOGY: CLINICAL ОBSERVATION
Authors: Tlish M. M. , Popovskayа E. B. , Sycheva N. L. , Sorokina N. V. , Psavok F. A.
Published: February 2022

The article analyzes the literature on polymorbidity of immune dermatoses. They confirm the possibility of combining with each other immune diseases, due to the presence of immune and metabolic abnormalities that are characteristic for the majority of chronic dermatoses and may indicate the possibility of combining several nosology. We present 2 clinical cases polymorbidity. In the first case — a combination demonstrated in one patient planus, idiopathic atrophoderma Pasini — Pierini and multi-colored lichen. In the second case detected combination of 4 kinds of dermatological diseases — horny eczema, psoriasis vulgaris, scleroderma, and rosacea. Patients underwent complex clinical examination and histomorphological examination of skin biopsies. The presented clinical cases demonstrate the possibility of a combination of several skin diseases in one patient with common etiopathogenic mechanisms
Gonococcal infection incidence rate in the russian federationin 1999-2009
Authors: Rakhmatulina M R , Melekhina L E , Vasil'eva M Yu , Litvin O E , Rakhmatulina M R , Melekhina L Ye , Vasiliyeva M Yu , Litvin O Ye
Published: February 2022

The article presents a comparative analysis of the gonococcal infection incidence rate among adult population (aged
18 and older) and teenagers (aged 15-17) carried out based on the official statistical reporting for the subjects, federal
districts and in the Russian Federation in general in 1999-2009
Current methods to identify the gonococcal infection pathogen
Authors: Frigo N V , Polevshchikova S A , Volkov I A , Shatalova A Yu , Rakhmatulina M R , Solomka V S , Frigo N V , Polevshchikova S A , Volkov I A , Shatalova A Yu , Rakhmatulina M R , Solomka V S
Published: February 2022

The authors present the data on the current laboratory methods and recommendations for identifying the gonorrhea
pathogen applied in Russia and abroad: microscopy method, cultural (bacteriological) study method, nucleic acid
amplification techniques and DNA chip technology. The benefits and shortcomings of each of the techniques have been
compared. The authors emphasize the cultural method is currently considered to be the key one for diagnosing gonorrhea
due to its high specificity and sensitivity making it possible to define the N.gonorrhoeae sensitivity to antimicrobial
drugs, which is very important taking into consideration the N. gonorrhoeae resistance to antibiotics. The nucleic acid
amplification techniques and, first of all, polymerase chain reaction, can be used in Russia as screening methods. The
results obtained by using the techniques need confirmation by the cultural method.
The role of molecular and genetic methods to determine theТ-cell and В-cell clonality in diagnosing malignant cutaneouslymphomas
Authors: Molochkov V A , Sidorova Yu V , Groznova A A , Ovsyannikova G V , Fedorovskaya A V , Molochkov A V , Sudarikov A B , Molochkov A V , Sidorova Yu V , Groznova A A , Ovsyannikova G V , Fedorovskaya A V , Molochkov A V , Sudarikov A B
Published: February 2022

The article presents the data on the studies contributing to improving the differential diagnostics of T-cell and B-cell
cutaneous lymphomas including large-plaque parapsoriasis and T-cell and B-cell cutaneous pseudolymphomas as well
as frequency of their transformation into malignant cutaneous lymphomas. There was a study of 101 patients using the
polymerase chain reaction method to determine the T-cell and B-cell lymphocyte clonality by genes of g and  chains in
the T-cell receptor and immunoglobulin heavy chain genes. Monoclonality was determined in 40 of 46 cases in patients
with T-cell cutaneous lymphomas and in three of four cases in patients with B-cell cutaneous lymphomas. Monoclonality
was revealed in one of 14 cases of large-plaque parapsoriasis and one of two cases of T-cell cutaneous pseudolymphoma.
In all of the 24 cases of chronic benign dermatoses, five cases of small-plaque parapsoriasis and ten skin tissue samples
obtained from healthy donors, polyclonal lymphocytes were revealed. So, the obtained results make it possible to
consider the method to be an important addition in the field of diagnosing lymphoproliferative skin diseases.
A comparative appraisal of the efficacy of different rosaceatreatment methods
Authors: Perlamutrov Yu N , Saydalieva V Sh , Ol'khovskaya K B , Perlamutrov Yu N , Saidaliyeva V Sh , Olkhovskaya K B
Published: February 2022

There was a comparative appraisal of the efficacy of different papulopustular rosacea treatment methods: systemic
administration of metronidazole, doxycycline hydrochloride and isotretinoin.
The therapy efficacy was appraised based on the dynamics of the indices on the rosacea diagnostics scale in 98 patients
suffering from papulopustular rosacea.
Retinoid proved to be of maximum efficacy, which was confirmed by a more intense decrease in the indices on the
rosacea diagnostics scale with a high share of remission patients.
Conclusion: Isotretinoin has the maximum anti-inflammatory efficacy for treating patients with papulopustular rosacea.