bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Genomic Biomarkers for Pembrolizumab Response: A Real-World Approach and Patient Similarity Network Analysis Reveal DNA Response and Repair Gene Mutations as a Signature
Authors: Filetti Marco , Occhipinti Mario , Cirillo Alessio , Scirocchi Fabio , Ugolini Alessio , Giusti Raffaele , Lombardi Pasquale , Daniele Gennaro , Botticelli Andrea , Lo Russo Giuseppe , De Braud Filippo , Marchetti Paolo , Nuti Marianna , Ferretti Elisabetta , Farina Lorenzo , Rughetti Aurelia , Petti Manuela
Published: November 2024

Purpose: Single-agent immune checkpoint inhibitor (IO) therapy is the standard for non-oncogene-addicted advanced non-small cell lung cancer (aNSCLC) with PD-L1 tumor proportion score ≥ 50%. Smoking-induced harm generates high tumor mutation burden (H-TMB) in smoking patients (S-pts), while never-smoking patients (NS-pts) typically have low TMB (L-TMB) and are unresponsive to IO. However, the molecular characterization of NS-pts with H-TMB remains unclear. Experimental design: Clinical data of 142 aNSCLC patients with PD-L1 ≥ 50% treated with first line pembrolizumab were retrospectively collected. Next-generation sequencing was performed using the FoundationOne®CDx assay to correlate genomic alterations with clinical characteristics and response outcomes. Detected mutations were classified into eleven main pathways and enrichment analysis identified patient subgroups based on mutated pathways. Additionally, a patient similarity network was constructed to analyze molecular characterization. Results were validated using data from 853 aNSCLC patients in POPLAR and OAK trials. Results: Among the patients, S-pts had higher TMB than NS-pts. Interestingly, 11 (8%) NS-pts exhibited H-TMB and were enriched in β-catenin/Wnt and DDR pathway mutations. DDR pathway mutations were confirmed to be enriched in NS-pts with H-TMB using data from POPLAR and OAK trials. In the real-world cohort, the NS/H-TMB subgroup with DDR pathway mutations demonstrated improved IO outcome. Patient similarity network analysis confirmed the clustering of NS/H-TMB patients with DDR mutations and their association with improved overall survival in both the real-world cohort and the trials. Conclusions: The DDR signature has a potential role as an additional generator of H-TMB in NS-pts. This subgroup of IO-responsive NS-pts may have better prognosis. Our findings suggest that DDR-based mutational profiling may help identify NS-pts who could benefit from IO therapy.
The Emerging Roles of the Stress Epigenetic Reader LEDGF/p75 in Cancer Biology and Therapy Resistance: Mechanisms and Targeting Opportunities
Authors: Ortiz-Hernandez Greisha L. , Sanchez-Hernandez Evelyn S. , Ochoa Pedro T. , Casiano Carlos A.
Published: November 2024

The lens epithelium derived growth factor of 75 kD (LEDGF/p75) is a transcription co-activator and epigenetic reader that has emerged as a stress oncoprotein in multiple human cancers. Growing evidence indicates that it promotes tumor cell survival against certain therapeutic drugs. The amino (N)-terminal region of LEDGF/p75 contains a PWWP domain that reads methylated histone marks, critical for recognizing transcriptionally active chromatin sites. Its carboxyl (C)-terminus has an integrase binding domain (IBD) that serves as the binding site for the HIV-1 integrase and multiple oncogenic transcription factors. Acting as hubs for protein-protein interactions, both domains facilitate the tethering of oncogenic transcription factors and regulators to active chromatin to regulate mRNA splicing, promote DNA repair, and enhance the expression of stress and cancer-related genes that contribute to tumor cell aggressiveness and chemoresistance. This review summarizes our current knowledge of the emerging roles of LEDGF/p75 in cancer biology and therapy resistance and discusses its potential as a novel oncotherapeutic target in combinatorial treatments.
The Vascular Endothelial Growth Factor-A121/Vascular Endothelial Growth Factor-A165 Ratio as a Predictor of the Therapeutic Response to Immune Checkpoint Inhibitors in Gastric Cancer
Authors: Hamada Yuki , Tanoue Kiyonori , Arigami Takaaki , Yamakuchi Munekazu , Okawa Masashi , Matsushita Daisuke , Takenouchi Kazunori , Yamada Shingo , Maywar Drew N. , Nakayama Chieri , Oyama Yoko , Higashi Sadayuki , Fujisaki Chieko , Hozaka Yuto , Kita Yoshiaki , Hashiguchi Teruto , Ohtsuka Takao
Published: November 2024

Background/Objectives: The response rate to immune checkpoint inhibitor (ICI) therapy is limited. Further, there is a need to discover biomarkers to predict therapeutic efficacy. The vascular endothelial growth factor (VEGF) is strongly associated with intra-tumoral immunity; however, its utility as a marker remains unknown. Therefore, our objectives were to examine the isoforms of VEGF and determine whether VEGF levels predict ICI efficacy. Methods: Levels of VEGF isoforms VEGF-A121 and VEGF-A165 were measured in stored serum samples obtained from 30 patients with advanced or recurrent gastric cancer who received nivolumab monotherapy at Kagoshima University Hospital, and the association with prognosis and treatment efficacy was retrospectively analyzed. Results: The serum levels of the total VEGF, VEGF-A121, and VEGF-A165 were not significantly associated with prognosis. However, the ratio of VEGF-A121/VEGF-A165 (VEGF-A121/165) exhibited a statistically significant (p = 0.0088) difference in progression-free survival (PFS) with the low-ratio group having a 67-day prolonged median PFS time. Under univariable analysis, only VEGF-A121/165 values exhibited reduced progression-free survival with statistical significance. When comparing treatment responses in the low (n = 15) and high (n = 15) serum VEGF-A-121/165 groups, RECIST evaluation was 3 to 0 for complete response (CR), 2 to 0 for partial response (PR), 3 to 2 for stable disease (SD), and 3 to 10 for progressive disease (PD). Patients with clinically unsettled PR or SD were classified as non-CR/non-PD (4 vs. 3), with a disease control rate of 80% vs. 33%. Conclusions: The serum VEGF-A121/165 ratio may represent a new, easily measured biomarker for predicting the therapeutic response to ICIs.
Patterns of Childhood Cancer Mortality in Hungary Since the Turn of the Millennium, Including the Two Years of the COVID-19 Pandemic
Authors: Németh Kristóf , Nyári Tibor András , Lantos Tamás
Published: November 2024

Objectives: We aimed to analyse the pattern of childhood cancer mortality among children under 15 years in Hungary between 2001 and 2021. In addition, annual and cyclical trends were examined. Methods: The number of deaths was obtained from the nationwide population register over the study period by gender, age group, and region for each year. Data were analysed using the Poisson regression method and cyclic trends were investigated using the Walter–Elwood method. Results: Overall, 14,931 childhood deaths (1092 from cancers) were registered between 2001 and 2021. The cancer mortality risk was significantly higher among boys than girls. A significantly decreasing trend was detected for yearly childhood cancer mortality rates, with an annual IRR of 0.976 (95% CI: 0.966–0.986; p < 0.001). This tendency was not influenced by the pandemic. However, different patterns of seasonal variation were revealed in childhood cancer mortality rates during 2020–2021 and 2001–2019. Conclusions: The annual trend in childhood cancer mortality was not affected by the coronavirus pandemic. However, there was a different pattern of childhood cancer mortality during the pandemic and non-pandemic period in Hungary. Considering the seasonal variation in monthly childhood cancer mortality rates, we hypothesized that environmental factors might play an important role in the aetiology of childhood cancer deaths.
Correction: Ádány et al. Discrepancies between the Spatial Distribution of Cancer Incidence and Mortality as an Indicator of Unmet Needs in Cancer Prevention and/or Treatment in Hungary. Cancers 2024, 16, 2917
Authors: Ádány Róza , Juhász Attila , Nagy Csilla , Burkali Bernadett , Pikó Péter , McKee Martin , Oroszi Beatrix
Published: November 2024

In the original publication [...]
Benefits of Physical Activity in Children with Cardiac Diseases—A Concise Summary for Pediatricians
Authors: Luca Alina Costina , Țarcă Elena , Tănase Valentina-Georgiana , Pădureț Ioana-Alexandra , Dragoiu Teodora-Simina , Butnariu Lăcrămioara Ionela , Roșu Solange Tamara , Roca Iulia Cristina , Mîndru Dana-Elena
Published: November 2024

A physically active lifestyle offers multiple benefits, including lowering the risk of cardiovascular disease, lowering body-mass index (BMI), and, last but not least, improving the quality of life. However, there are still disincentives to physical activity in children with heart diseases due to the high protection of parents and the scarcity of data in the literature. The purpose of this paper is to help pediatricians and pediatric cardiologists identify the type of physical activity allowed in children with congenital cardiac malformations, thus minimizing the risk of major adverse effects, such as acute coronary syndrome and sudden cardiac death. Therefore, we searched various electronic databases, such as PubMed, ScienceDirect, and Embase. We selected 61 articles published between 2008–2024. These articles included data on pediatric patients, from newborn to adolescent age. We decided to choose the 2008 study because of its focus on the essential role of education in schools regarding physical activity and the prevention of complications from sedentary lifestyles. Subsequently, we analyzed the data available in the literature up to 2024 regarding the type, intensity, and duration of exercise for patients with various congenital heart malformations. The conclusions of this review are presented based on the category of heart disease. There are differences in the free practice of sports in children with cardiomyopathies, atrioventricular block, arrhythmias with a genetic substrate, valvulopathies, and cyanogenic and non-cyanogenic congenital malformations. For example, children with arrhythmogenic right ventricle cardiomyopathy are not allowed to participate in sports competitions, but they can perform low physical activity for 150 min/week—golf, table tennis, and photography. However, it is recognized that a physically active lifestyle correlates with a decreased risk of cardiovascular diseases, body mass index, and an improvement in the quality of life. Children with congenital heart disease who are active have improved their cardiovascular systems.
Cornelia de Lange Syndrome Accompanied by Cholelithiasis and Nephrolithiasis: A Case Report
Authors: Choi So Yoon , Hong Yoo-Rha , Oh Chi-Eun , Lee Jung Hyun
Published: November 2024

Cornelia de Lange syndrome (CdLS) is a rare genetic disorder characterized by a distinctive facial appearance, growth/cognitive retardation, developmental delay, skeletal malformation, hypertrichosis, and other abnormalities. Patients with mild CdLS have less severe phenotypes, while retaining representative facial features. Mutations in the genes NIPBL, SMC1A, SMC3, HDAC8, and RAD21 have been associated with CdLS, with mutations in NIPBL accounting for approximately 60% of cases. Herein, we present a case of CdLS accompanied by cholelithiasis and nephrolithiasis. A 9-year-old Korean boy presented with vomiting and abdominal pain. Abdominal ultrasonography revealed several gallstones and renal stones. Extracorporeal shock wave lithotripsy failed; therefore, cholecystectomy and nephrolithotomy were performed. Postoperative stone composition analysis revealed calcium oxalate as the primary component. CdLS was suspected based on the characteristic appearance and physical examination, with genetic testing confirming an NIPBL gene mutation. Simultaneous CdLS, cholelithiasis, and nephrolithiasis requires careful management and treatment tailored to each patient’s specific needs and challenges.
Outcome of Neonatal Hydronephrosis, a New Cut-Off to Identify Patients with Spontaneous Resolution
Authors: Gatto Antonio , Ferretti Serena , Colonna Arianna Turriziani , Capossela Lavinia , Chiaretti Antonio , Covino Marcello , Rendeli Claudia
Published: November 2024

Background/Objectives: The anteroposterior renal pelvis diameter (APRPD) is used to assess the grade of urinary tract dilatation (UTD). There is no univocal method stratifying the risk of complications related to postnatal UTD. This study aims to identify APRPD cut-offs at birth to determine outcome stratification and second-level exams. Methods: The records of a cohort of newborns with unilateral or bilateral UTD confirmed or detected by ultrasound after birth between 2010 and 2020 were analyzed. These children underwent further examinations at 3, 6, 12, and 24 months of age. Results: We managed 500 children with postnatal UTD, with a median APRPD at 0–2 months of age of 7.7 mm [IQR 6.0–10.0]. As for UTD resolution, 279 (55.8%) patients had a complete resolution at the age of 6 months; an additional 55, for a total of 344 (68.8%), at 9–12 months; and 19, for a total of 353 (70.6%), at 24 months. An APRPD value ≤ 8.5 mm showed a sensitivity of 80.4% (95% CI [76.0–84.4]) and a specificity of 100.0% (95% CI [76.8–100.0]) in identifying candidates for spontaneous resolution within 24 months of life. An APRPD value ≤ 8.5 mm was also an independent prognostic factor of resolution at the age of 24 months (p = 0.000). Conclusions: Isolated hydronephrosis is the most frequent urinary tract abnormality detected in pregnancy. A well-structured prenatal and postnatal management plan is indeed necessary. According to our analyses, 8.5 mm can be used as a cut-off to reassure parents and clinicians of the benignity of the postnatal dilatation.
The mPower (Mother’s Power) Initiative: Improving Health Behavior Through Peer Support and Health Literacy for Mothers of Children with Cerebral Palsy in Rural Bangladesh
Authors: Perrins Genevieve , Jahan Israt , Khan Md. Nuruzzaman , Al Imam Mahmudul Hassan , Power Rosalie , King Catherine , Muhit Mohammad , Badawi Nadia , Khandaker Gulam
Published: November 2024

Background/Objectives: Cerebral palsy (CP) affects a substantial number of children, particularly in low- and middle-income countries such as Bangladesh. Maternal health literacy is critical to the health and well-being of children with CP, particularly in low-resource settings. In this study, we sought to assess how the mPower (mother’s power) community-based intervention impacted mothers’ CP-specific knowledge, as well as their utilization of rehabilitation services in rural Bangladesh. Methods: This quasi-experimental study was conducted with a group of mothers of children with CP, formed through the ongoing initiatives of the Bangladesh CP Register in rural Bangladesh. A pre-post-intervention comparison method was used to assess the outcomes of the intervention. Results: Mothers who participated in over two-thirds of the mPower sessions demonstrated a significant increase in CP-related knowledge (75.5% vs. 63.6%, p = 0.04). Additionally, mothers who attended two-thirds of the mPower sessions utilized rehabilitation services more often compared to those who attended fewer sessions (55.3% vs. 22.6%, p < 0.001). Conclusions: The mPower intervention successfully improved health literacy and likely increased rehabilitation service utilization among mothers of children with CP in rural Bangladesh.
Characterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia
Authors: Hasegawa Takuya , Kawahara Kohichi , Sato Koji , Asano Yoshihisa , Maeda Takehiko
Published: November 2024

Cancer cachexia is a debilitating syndrome characterized by progressive weight loss, muscle wasting, and systemic inflammation. Despite the prevalence and severe consequences of cancer cachexia, effective treatments for this syndrome remain elusive. Therefore, there is a greater need for well-characterized animal models to identify novel therapeutic targets. Certain manifestations of cachexia, such as pain and depression, have been extensively studied using animal models of cancer-induced bone pain (CIBP). In contrast, other aspects of cachexia have received less attention in these models. To address this issue, we established the CIBP model by injecting Lewis lung carcinoma into the intramedullary cavity of the femur, observed cachexia-related symptoms, and demonstrated the utility of this model as a preclinical platform to study cancer cachexia. This model accurately recapitulates key features of cancer cachexia, including weight loss, muscle atrophy, adipose tissue depletion, CIBP, and anxiety. These findings suggest that psychological factors, in addition to physiological and metabolic factors, play significant roles in cancer cachexia development. Our model offers a valuable resource for investigating the underlying mechanisms of cancer cachexia and for developing innovative therapeutic strategies that target physical and psychological components.
The Anti-Inflammatory Roles of Vitamin D for Improving Human Health
Authors: Fenercioglu Aysen Kutan
Published: November 2024

Vitamin D receptors (VDRs) are present in almost all cells of the immune system, including B cells, T cells, NK (Natural Killer) cells, dendritic cells, and monocytes, as well as the epithelial cells of many organs such as the intestine, pancreas, prostate, lungs, and cardiomyocytes. In addition, some immune cells, including dendritic cells, macrophages, and B and T cells, can synthesize calcitriol by expressing 1α-hydroxylase. Upon binding to VDRs, vitamin D (Vit D) regulates the expression of genes involved in immune responses, including those encoding for cytokines. It modulates the production of pro-inflammatory cytokines while promoting the synthesis of anti-inflammatory cytokines. Vit D also affects the differentiation and maturation of cells of the immune system. By inhibiting the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, Vit D reduces the expression of pro-inflammatory genes. These effects highlight the potential of Vit D as a therapeutic agent in the management of inflammatory diseases, including autoimmune disorders, cardiovascular diseases, diabetes, metabolic syndrome, cancer, neurological diseases, depression, and inflammatory bowel disease.
Estimating Surface Urban Heat Island Effects of Abeokuta Within the Context of Its Economic Development Cluster in Ogun State Nigeria: A Baseline Study Utilising Remote Sensing and Cloud-Based Computing Technologies
Authors: Odunsi Oluwafemi Michael , Rienow Andreas
Published: November 2024

The demands for growth and prosperity in developing countries have prompted Ogun State to initiate six economic development clusters oriented around its urban areas. However, little attention has been given to the environmental impact of these clusters in relation to temperature change and thermal consequences. Serving as a baseline study for the Abeokuta Cluster, whose implementation is still ongoing, this study analysed the surface urban heat island (SUHI) effects for 2003, 2013, and 2023 to determine whether variations in these effects exist over time. The study utilised satellite imagery from Landsat sensors and the cloud computing power of Google Earth Engine for data collection and analysis. Findings revealed that Abeokuta City experienced varying degrees of high SUHI effects, while the surrounding areas proposed for residential and industrial development in the Abeokuta Cluster showed low SUHI effects. The differences in SUHI effects within Abeokuta City across the years were found to be statistically significant (Fwithin = 3.158, p = 0.044; Fbetween = 5.065, p = 0.025), though this was not the case for the Abeokuta cluster as a whole. This study recommends urban planning strategies and policy interventions to combat SUHI effects in Abeokuta City, along with precautionary measures for the Abeokuta Cluster.
Immediate Effects of the Mandibular Muscle Energy Technique in Adults with Chronic Temporomandibular Disorder
Authors: Márquez-Vera Antonio , Polo-Ferrero Luis , Puente-González Ana Silvia , Méndez-Sánchez Roberto , Blanco-Rueda José Antonio
Published: November 2024

Background/Objectives: Temporomandibular disorders affect the muscles used for chewing, the temporomandibular joint, and other related tissues, resulting in pain, limited mobility, and dysfunction of the masticatory muscles. Physical therapy plays a critical role in treatment. Manual therapy can trigger neurophysiological mechanisms that contribute to pain relief and a reduction in muscle activation. Evaluations of different manual therapy techniques are needed on this topic. The main objective of this study was to evaluate the effects of a specific manual therapy technique (the mandibular muscle energy technique) in adults with temporomandibular disorders. Methods: A randomized, parallel clinical trial was conducted, and 31 participants were recruited into an experimental group and 30 were recruited into a control group in order to analyze its effects on outcomes such as pain, pain threshold to pressure, mandibular mobility, and kinesiophobia. Pre- and post-intervention assessments were performed, followed by statistical analyses to verify the intra- and intergroup changes. Results: The results showed that the mandibular muscle energy technique produced positive effects with significant differences in the intra- and intergroup comparisons for pain threshold to pressure, mandibular mobility, and kinesiophobia, demonstrating its efficacy and safety as a treatment option for adults with temporomandibular disorders, with proven effects in the short term. Conclusions: The effects obtained and the absence of side effects showed that this technique can be integrated into multimodal treatment along with other types of interventions in patients with temporomandibular disorders.
Potential of Deer Placenta Extract in Hair Cell Regeneration and Its Nanoniosome-Microspicule Gel as a Transfollicular Delivery System
Authors: Rangsimawong Worranan , Duangjit Sureewan , Sritananuwat Phaijit , Ngawhirunpat Tanasait , Opanasopit Praneet
Published: November 2024

Background: Deer placenta extract (DPE), rich in bioactive macromolecules, promotes regenerative effects in both normal and damaged cells. However, effective delivery of these macromolecules through the skin remains a challenge. Objectives: To investigate the potential of DPE in regenerating hair cells and to develop a nanoniosome (NS) and microspicule (MS) formulation as a promising transfollicular delivery system. Methods: The bioactivity of DPE was assessed in human follicle dermal papilla (HFDP) cells, including cells damaged by chemotherapy. The NS-MS formulation was designed to deliver biomacromolecules from DPE into skin and hair follicles. Results: DPE at 2000 µg/mL exhibited no cytotoxicity and significantly enhanced proliferation in both normal and cisplatin-treated HFDP cells. The DPE-loaded NSs displayed nanovesicles with a uniform size distribution and a negative surface charge. When incorporated into the MS gel, NS-MS demonstrated a synergistic effect, significantly enhancing the transdermal and transfollicular delivery of macromolecular protein into the skin layers and hair follicles. Conclusions: DPE promoted hair cell proliferation and facilitated the recovery of hair cells damaged by chemotherapy, especially when formulated into the NS-MS system, which effectively delivered bioactive macromolecules to the target site. This suggests its potential role in promoting hair regrowth.
Research on the Correlation Between Skin Elasticity Evaluation Parameters and Age
Authors: Chen Dandan , Yin Shipeng , Lu Xuelian , Fu Haokun , Gao Hongqi , Zhang Suning
Published: November 2024

This study aims to explore the impact of aging on skin elasticity, a key biomechanical property that diminishes over time, using the Cutometer to assess viscoelastic parameters. Methods: Researchers analyzed 22 viscoelastic parameters from the facial skin of 60 women aged 18 to 70. Key Results: The findings indicate that relaxation phase parameters, particularly biological elasticity (R7), exhibited the strongest negative correlation with age (r = −0.62), signifying a notable decline in biological elasticity as women age. In contrast, maximum deformation during the first cycle (R0) and the total area under the upper curve after 10 cycles of deformation (F4) also showed significant negative correlations with age (r = −0.47, r = −0.48), suggesting that younger skin typically presents higher values. These correlations raise questions regarding practical applications, as the presence of moisturizers and emollients may alter the stratum corneum’s properties, thus impacting these measurements. Additionally, the ratio of delayed deformation to instantaneous deformation (R6) demonstrated a positive correlation with age (r = 0.49), indicating its potential as a marker for skin aging. Conclusions: This study highlights the critical role of relaxation phase parameters in accurately reflecting skin elasticity changes associated with aging. The results offer valuable insights for evaluating cosmetic efficacy, reinforcing the need for a nuanced understanding of how various parameters interact. These findings contribute to the ongoing development of more effective anti-aging treatments and products.
Assessment of Wind Energy Potential Generated by Vehicles: A Case Study in Mexico
Authors: Moreno-Pacheco Luis Alfonso , Sánchez-Hueto Leopoldo José Luis , Barbosa-Saldaña Juan Gabriel , Martínez-Trinidad José , Toledo-Velázquez Miguel , García-León Ricardo Andrés
Published: November 2024

This research focuses on analyzing the aerodynamic characteristics of residual air currents generated by vehicle movement and evaluating their feasibility for energy generation, then designing a vertical axis wind turbine. The parameters assessed include the characteristic velocity profile, the average and maximum velocities, disturbance lifetimes, as well as the frequency and probability of recurrence of these disturbances. Using the data, projections are made on the electrical energy amount that can be produced by a wind turbine operating under such wind conditions. Measurements were taken at four locations: three within Mexico City (CDMX) and one on the outskirts. The measurement station, consisting of a 2.35 m vertical tower equipped with eight vertically aligned thermos-resistive anemometers, is installed on medians less than 0.50 m from moving vehicles. The data from within CDMX show maximum wind velocities ranging from 6 to 8 m/s at ground level, while measurements on the outskirts record velocities of up to 19.5 m/s. A probabilistic analysis reveals that usable air currents could be present 58% of the time. Based on electrical production calculations, it is estimated that harnessing this residual energy could power approximately 4500 homes, considering the national cost per kWh and the average electricity consumption of a four-person household.
Essential Elements for Implementing AI Tools in Elementary School: A Systematic Literature Review
Authors: Arriola-Mendoza Jorge , Valerio-Ureña Gabriel
Published: November 2024

The global use of Artificial Intelligence (AI) has attracted considerable attention, and its integration into educational systems is a priority that warrants further exploration. In collaboration with UNESCO, numerous organizations have proposed parameters advocating for the inclusion of AI in basic education systems. A systematic literature review (SLR) was conducted to identify these parameters from the existing research. Although these parameters have been mentioned in some studies, they are generally not prioritized in the research landscape. AI tools are primarily used to support students, while teachers typically employ a pedagogical approach centered on in-class activities. Additionally, essential conditions related to research requirements and involvement from the private and third sectors showed consistent adherence across the examined studies. However, it was found that only 52% of the studies included an ethical declaration regarding the data collected by AI during research development, especially regarding studies involving children. This review provides a guide for educational communities looking to enhance pedagogical practices through AI integration into their educational environments, but who may be uncertain about where to begin. Questions related to AI modality selection, pedagogical relevance, ethical considerations, and procedural guidelines for integrating AI into curricula are addressed through the insights provided in this review.
Scaffolding Criticality: Iterations of Theory in Principal Preparation
Authors: Jimerson Jo Beth , Myers Ron D.
Published: November 2024

Theory can be of immense value in practice and to practitioners, but is sometimes perceived as esoteric and inaccessible, or divorced from “real-world” knowledge and skills needed to enact school leadership. Policy and scholarship also call for the development of school leaders capable of thinking in ways informed by a range of theories that help leaders consider issues from various perspectives. Developing principals capable of leading for the moment and in ways that improve PK–12 systems requires us to communicate about theory in a way that positions it as a window into and lens for practice and to make theory approachable for students. In this paper, drawing on scholarship and on our roles as principal preparation faculty and as former school principals, we outline a framework for thinking about and with theory in principal preparation and for embedding theory in learning in explicit ways. Together, the iterations of theory we discuss scaffold the ability of leaders to use theory to frame critical analyses, problem-solve, broaden awareness of educational and societal issues, and constructively critique K–12 education.
The Role of Psychological Factors and Resilience in Mediating Sports Passion in Triathletes
Authors: Ancarani Francesca , Gavín-Chocano Óscar , Molero David , Vicente-Rodríguez Germán
Published: November 2024

The present study aims to analyze the psychological characteristics associated with the performance of amateur athletes, exploring their relationships with key variables such as resilience, harmonious and obsessive passion, and perception of discomfort. The main objective is to establish the relationship between psychological characteristics and each of the variables used (resilience, personal competence, and acceptance of self and life), and to consider whether these are related to passion (harmonious and obsessive) through a structural equation analysis. The sample was composed of 110 persons: 87 adults (22 females, mean age 40.7 ± 9.1 years; 65 males, mean age in years 42.1 ± 11.9) and 23 adolescents (16 females, mean age 14.8 ± 1.3 years; 7 males, mean age 15.3 ± 2.1 years). Psychological characteristics were assessed using the Psychological Characteristics Related to Performance (CPRD) questionnaire, passion using the Passion Scale instrument, and resilience using the Resilience Scale (RS-14) questionnaire. The analyses were based on a structural equation model analysis (PLS-SEM). The results showed adequate coefficients of determination (R index2) and Stone–Geisser predictive relevance (Q2) for the personal competence resilience factors (R2 = 0.517; Q2 = 0.218) and acceptance of self and life (R2 =.415; Q2 = 0.231), as well as for the passion dimensions harmonious passion (R2 = 0.357; Q2= 0.168) and obsessive passion (R2 = 0.085; Q2= 0.034). In conclusion, a close relationship was demonstrated between psychological characteristics related to sports performance and the variables of resilience and passion (both harmonious and obsessive). In particular, it was confirmed that mental skills and stress management are linked to the dimensions of resilience, and these dimensions influence both types of passion. In addition, team cohesion and personal competence also play a crucial role in the development of passion, highlighting the importance of these factors in the assessment of sports performance and influencing the well-being of amateur athletes in their personal and sports development.
Lightweight Segmentation Method for Wood Panel Images Based on Improved DeepLabV3+
Authors: Mou Xiangwei , Chen Hongyang , Yu Xinye , Chen Lintao , Peng Zhujing , Wang Rijun
Published: November 2024

Accurate and efficient pixel-wise segmentation of wood panels is crucial for enabling machine vision technologies to optimize the sawing process. Traditional image segmentation algorithms often struggle with robustness and accuracy in complex industrial environments. To address these challenges, this paper proposes an improved DeepLabV3+-based segmentation algorithm for wood panel images. The model incorporates a lightweight MobileNetV3 backbone to enhance feature extraction, reducing the number of parameters and computational complexity while minimizing any trade-off in segmentation accuracy, thereby increasing the model’s processing speed. Additionally, the introduction of a coordinate attention (CA) mechanism allows the model to better capture fine details and local features of the wood panels while suppressing interference from complex backgrounds. A novel feature fusion mechanism is also employed, combining shallow and deep network features to enhance the model’s ability to capture edges and textures, leading to improved feature fusion across scales and boosting segmentation accuracy. The experimental results demonstrate that the improved DeepLabV3+ model not only achieves superior segmentation performance across various wood panel types but also significantly increases segmentation speed. Specifically, the model improves the mean intersection over union (MIoU) by 1.05% and boosts the processing speed by 59.2%, achieving a processing time of 0.184 s per image.
A Practical Approach to Formal Methods: An Eclipse Integrated Development Environment (IDE) for Security Protocols
Authors: Garcia Rémi , Modesti Paolo
Published: November 2024

In order to develop trustworthy distributed systems, verification techniques and formal methods, including lightweight and practical approaches, have been employed to certify the design or implementation of security protocols. Lightweight formal methods offer a more accessible alternative to traditional fully formalised techniques by focusing on simplified models and tool support, making them more applicable in practical settings. The technical advantages of formal verification over manual testing are increasingly recognised in the cybersecurity community. However, applying formal methods, even in their more practical forms, outside highly specialised research settings remains challenging. For practitioners, formal modelling and verification are often too complex and unfamiliar to be used routinely. In this paper, we present an Eclipse Integrated Development Environment for the design, verification, and implementation of security protocols and evaluate its effectiveness, including feedback from users in educational settings. It offers user-friendly assistance in the formalisation process as part of a Model-Driven Development approach. This IDE centres around the Alice & Bob (AnB) notation, the AnBx Compiler and Code Generator, the OFMC model checker, and the ProVerif cryptographic protocol verifier. For the evaluation, we identify the six most prominent limiting factors for formal method adoption, based on relevant literature in this field, and we consider the IDE’s effectiveness against those criteria. Additionally, we conducted a structured survey to collect feedback from university students who have used the toolkit for their projects. The findings demonstrate that this contribution is valuable as a workflow aid and helps users grasp essential cybersecurity concepts, even for those with limited knowledge of formal methods or cryptography. Crucially, users reported that the IDE has been an important component to complete their projects and that they would use again in the future, given the opportunity.
Radio Front-End for Frequency Agile Microwave Photonic Radars
Authors: Blatnik Aljaž , Zmrzlak Luka , Batagelj Boštjan
Published: November 2024

Recent advancements in photonic integrated circuits (PICs) have paved the way for a new era of frequency-agile coherent radar systems. Unlike traditional all-electronic RF radar techniques, fully photonic systems offer superior performance, overcoming bandwidth limitations and noise degradation when operating across S (2–4 GHz), X (8–12 GHz), and K-band (12–40 GHz) frequencies. They also exhibit excellent phase noise performance, even at frequencies exceeding 20 GHz. However, current state-of-the-art PICs still suffer from high processing losses in the optical domain, necessitating careful design of the electrical RF domain. This study delves into the critical challenges of designing RF front-ends for microwave photonic radars, including stability, noise minimization, and intermodulation distortion reduction. To demonstrate the feasibility of the proposed design, a functional prototype is constructed, achieving a total power gain of 107 dB (radar system at 10 GHz) while minimizing signal noise degradation. Furthermore, a comprehensive demonstration of the RF front-end, encompassing both optical RF signal generation and experimental measurements of a rotor blade’s Doppler fingerprint with 0.5 Hz resolution, validates the proposed system’s performance.
PySpice-Simulated In Situ Learning with Memristor Emulation for Single-Layer Spiking Neural Networks
Authors: Jurj Sorin Liviu
Published: November 2024

This paper presents a novel approach to in situ memristive learning by training spiking neural networks (SNNs) entirely within the circuit using memristor emulators in SPICE. The circuit models neurons using Lapicque neurons and employs pulse-based spike encoding to simulate spike-timing-dependent plasticity (STDP), a key learning mechanism in SNNs. The Lapicque neuron model operates according to the Leaky Integrate-and-Fire (LIF) model, which is used in this study to model spiking behavior in memristor-based SNNs. More exactly, the first memristor emulator in PySpice, a Python library for circuit simulation, was developed and integrated into a memristive circuit capable of in situ learning, named the “In Situ Memristive Learning Method for Pattern Classification”. This novel technique enables time-based computation, where neurons accumulate incoming spikes and fire once a threshold is reached, mimicking biological neuron behavior. The proposed method was rigorously tested on three diverse datasets: XPUE, a custom non-dominating 3 × 3 image dataset; a 3 × 5 digit dataset ranging from 0 to 5; and a resized 10 × 10 version of the Modified National Institute of Standards and Technology (MNIST) dataset. The neuromorphic circuit achieved successful pattern learning across all three datasets, outperforming comparable results from other in situ training simulations on SPICE. The learning process harnesses the cumulative effect of memristors, enabling the network to learn a representative pattern for each label efficiently. This advancement opens new avenues for neuromorphic computing and paves the way for developing autonomous, adaptable pattern classification neuromorphic circuits.
Reactive Elements Control in LC Series Resonant Inverters by Current-Controlled Variable-Transformer and Magnetic Energy Recovery Switch for Induction Heating
Authors: Bellido Juan L. , Esteve Vicente , Jordán José
Published: November 2024

This work consists of the analysis and design of a LC series resonant inverter with reactive element control for induction heating hardening applications. This novel method uses a current-controlled variable transformer (VT) to control the reflected inductance of the inductor in the resonant, and a magnetic energy recovery switch (MERS) to vary the influence of the capacitor as a reactive power compensation element. This converter topology allows quality factor (Q) or operating frequency (fsw) to be adjusted, making it possible to harden workpieces of different geometries and materials with a single converter. In the article, the design of both elements will be studied and tested. Experimental results were carried out with a 10 kW induction heating inverter prototype, with a frequency range of 60 kHz to 100 kHz and a quality factor of 6 to 10, measuring efficiencies above 95%.
Sustainability of Rural Electrification Projects in Developing Countries: A Systematic Literature Review
Authors: Cuenca-Enrique Carlos , del-Río-Carazo Laura , Acquila-Natale Emiliano , Iglesias-Pradas Santiago
Published: November 2024

This study provides a review of the sustainability of rural electrification projects in developing countries to identify drivers of the long-term success of these initiatives. Unlike previous studies that often separate sustainability into social, economic, and environmental dimensions, this research adopts a comprehensive approach, acknowledging the interconnectedness of these aspects. Twenty-one sustainability drivers were identified. Based on these, a framework was proposed to organize them across project phases and key activities, supporting sustainable project planning and execution. This framework enables stakeholders to integrate sustainability considerations into the design and management of rural electrification projects, facilitating strategic action across diverse areas. The findings underscore well-known sustainability drivers such as renewable energy adoption while highlighting less-researched aspects, including project monitoring and waste management. Further studies should explore these under-researched areas and examine the potential of digitalization to enhance project sustainability, particularly as rural connectivity improves in developing countries. This approach can provide insights into optimizing rural electrification projects for long-term success and resilience.
The Influence of Building Materials and Electrical Parameter Variability on Electromagnetic Wave Propagation
Authors: Choroszucho Agnieszka , Szczegielniak Tomasz , Kusiak Dariusz
Published: November 2024

The article presents an analysis of the influence of building materials on the propagation of an electromagnetic wave and the values of the electric field intensity. The topics of the analysis were two types of walls (partition and load bearing) built of different building materials. Different variants of walls were considered due to the building material used: concrete, aerated concrete, solid brick, clinker bricks, and three types of hollow bricks. The requirements for structures in terms of wall thickness were taken into account. The article, using concrete as an example, also describes the influence of changes in the electrical parameters of the building material on wave propagation and the values of the field. The results concerning the influence of complex materials, such as hollow bricks, on the non-uniform distribution of the electric field were also included. Due to the different percentage share of ceramic mass in hollow bricks, the article discusses its influence on the values of the field, taking into account the variability of conductivity. The analysis was performed using the Finite Difference Time Domain (FDTD) method. The results were compared with the analytical solution. The analysis, among others, showed that with the increase in the ceramic mass in bricks, the electric field values are higher but result in an uneven distribution of the field. Using the example of hollow bricks used to build load-bearing walls, it was observed that a small modification of the hollows practically does not affect the field intensity (the difference is approx. 2%). When planning the installation of wireless networks, the best solution is walls made of ceramics with a large number of hollows, where the ceramic mass constitutes only approx. 30%. A multivariate analysis allows for a better understanding of field phenomena inside single-family homes.
The Use of Renewable Energy Sources in Households in Poland—Current Status and Prospects for the Development of Energy Prosumption
Authors: Trębska Paulina , Wysokiński Marcin , Trocewicz Anna , Żurakowska-Sawa Joanna , Tsybulska Julia , Płonka Aleksandra , Bórawski Piotr , Bełdycka-Bórawska Aneta
Published: November 2024

This article aimed to assess the use of renewable energy sources (RES) in households in Poland in the context of the Statistics Poland (GUS) research and our survey research. In addition, plans for using renewable energy sources and the willingness of respondents to spend money for this purpose were examined. At the beginning of this article, a theoretical approach to the household as an energy prosumer was presented, and the structure of obtaining energy from RES in Poland was shown. Then, the survey research methodology was presented, including the selection of the sample and the purpose of the survey. The next part of this article concerns the characteristics of the respondents and the buildings they inhabit, as well as statistics on RES used in the surveyed households. The research shows that 12% of the surveyed population was an energy prosumer, and 22% were interested in and planning to invest in RES. Only half of the respondents were ready to spend their money on micro-installations. The results were presented using the documentary and comparative methods. This article uses data from Statistics Poland (GUS) and our survey research conducted among 1112 representatives of households in Poland.
A Comprehensive Approach to Load Frequency Control in Hybrid Power Systems Incorporating Renewable and Conventional Sources with Electric Vehicles and Superconducting Magnetic Energy Storage
Authors: Nagendra K. , Varun K. , Pal G. Som , Santosh K. , Semwal Sunil , Badoni Manoj , Kumar Rajeev
Published: November 2024

This study addresses the load frequency control (LFC) within a multiarea power system characterized by diverse generation sources across three distinct power system areas. area 1 comprises thermal, geothermal, and electric vehicle (EV) generation with superconducting magnetic energy storage (SMES) support; area 2 encompasses thermal and EV generation; and area 3 includes hydro, gas, and EV generation. The objective is to minimize the area control error (ACE) under various scenarios, including parameter variations and random load changes, using different control strategies: proportional-integral-derivative (PID), two-degree-of-freedom PID (PID-2DF), fractional-order PID (FOPID), fractional-order integral (FOPID-FOI), and fractional-order integral and derivative (FOPID-FOID) controllers. The result analysis under various conditions (normal, random, and parameter variations) evidences the superior performance of the FOPID-FOID control scheme over the others in terms of time-domain specifications like oscillations and settling time. The FOPID-FOID control scheme provides advantages like adaptability/flexibility to system parameter changes and better response time for the current power system. This research is novel because it shows that the FOPID-FOID is an excellent control scheme that can integrate these diverse/renewable sources with modern systems.