bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of old house borer larvae in wooden structures by acoustic emission method – Influence of larval size and sensor location
Authors: Krajewski Adam , Jakiela Slawomir , Witomski Piotr
Published: May 2022

The detection of old house borer larvae (Hylotrupes bajulus L.) in Scots pine wood (Pinus sylvestris L.) was performed using the acoustic emission (AE) method. Laboratory experiments (as preliminary) as well as real tests in full-sized building elements were performed. The sound energy of larvae with a mass of 0.011 g to 0.065 g placed in small samples of wood was calculated. A remarkable relationship was found between the calculated sound energy and larva mass. The AE measurement of an old house borer larva in construction element with a cross-section of 11.0 cm × 5.5 cm and a length of 203 cm was also performed. A remarkable drop in calculated sound energy was observed with increasing distance of the sensor from the larval presence. Similar measurements were also conducted in wood with a cross-section of 1.5 cm × 1.5 cm and a length of 203 cm. There was a smaller decline in the calculated energy of sound than in previous studies. For this reason, the AE method should be used in detecting wood-boring insects in furniture.
Recent progress in the production of lignin-based sunscreens: A Review
Authors: Espinoza-Acosta José Luis , Figueroa-Espinoza Evelyn Guadalupe , Rosa-Alcaraz María de los Ángeles De la
Published: May 2022

Technical lignins are becoming an attractive natural, renewable, and non-toxic ingredient in sunscreens, having the capability for replacing synthetic compounds. Researchers have reported that lignin can increase the solar protection factor (SPF) of sunscreens and provide sun protection to body creams. However, to achieve the valorization of lignin in the fabrication of personal care products, it is necessary to overcome several challenges related to their molecular complexity and unattractive color. Fractionation, chemical modification, whitening, particle size reduction, and the synthesis of nanocomposites and copolymers are strategies reported to overcome the lignin challenges in the development of lignin-based sunscreens. This paper summarizes and analyzes previous research studies and outstanding findings (from 2016 to 2022) directed at the reduction of the problems that limit the extensive applications of lignin in skincare products such as sunscreens.
PENGEMBANGAN LKS (LEMBAR KERJA SISWA) BERBASIS LAYOUT MAJALAH PADA MATA PELAJARAN SEJARAH MATERI SUMPAH PEMUDA DI KELAS XI SMA NEGERI 5 BINJAI
Authors: Hasanah Wulani Kisty , Diansyah Arfan
Published: May 2022

ABSTRACTThe background of this research because of unattractive students worksheet in general, learning activity is still centered to the teacher/verbalistic and lack of using student worksheet in classroom activity. The purpose of this research is to develop SW (Student Worksheet) and to see the appropriateness based on magazine layout in History, Sumpah Pemuda subject matter in state senior high school 5 Binjai grade eleven. The method was used in this research using development model from Borg and Gall which divided into seven stages such as Preliminary study, Research planning, Developing early form product and design validation, Early trial, Product revision, Field trial and Final revision product. After tested, then the result of the research showed 91% scored (Including Valid Criteria) in early trial or field/large and able to attract student attentiveness learning on History subject.Keywords : Student Worksheet, Magazine Layout, History Subject ABSTRAKPenelitian ini dilatarbelakangi oleh kurang menariknya tampilan LKS pada umumnya, kegiatan belajar masih berpusat pada guru/verbalistik, dan kurangnya penggunaan LKS dalam kegiatan belajar mengajar. Adapun tujuan dalam penelitian ini yaitu Mengembangkan LKS (Lembar Kerja Siswa) Berbasis Layout Majalah Pada Mata Pelajaran Sejarah Materi Sumpah Pemuda di Kelas XI SMA Negeri 5 Binjai dan Melihat Kelayakan LKS (Lembar Kerja Siswa) Berbasis Layout Majalah Pada Mata Pelajaran Sejarah Materi Sumpah Pemuda di Kelas XI SMA Negeri 5 Binjai. Metode dalam penelitian ini menggunakan model pengembangan dari Borg and Gall yang terdiri dari tujuh tahapan yaitu studi pendahuluan, perencanaan penelitian, pengembangan format produk awal dan validasi desain, uji coba awal, revisi produk, uji coba lapangan, dan revisi produk. Setelah diuji cobakan, maka dapat diketahui bahwa hasil penelitian mengenai kelayakan LKS (Lembar Kerja Siswa) Berbasis Layout Majalah mendapatkan nilai 91% (termasuk kriteria sangat valid) baik uji coba awal maupun lapangan/luas dan mampu menarik perhatian siswa dalam pembelajaran sejarah.Kata Kunci : Lembar Kerja Siswa, Layout Majalah, Pembelajaran Sejarah
Pengaruh Model Pembelajaran Generatif Terhadap Tingkat Keaktifan Siswa Pada Mata Pelajaran IPS di SMP Al-Kamiliyyah Boarding School
Authors: Anggasari Wulan Dewi , Arif Muhammad , Nisa Jakiatin
Published: May 2022

Penelitian ini mengenai pengaruh model pembelajaran generatif, bertujuan untuk memperoleh data mengenai pengaruh penerapan model pembelajaran generatif terhadap tingkat keaktifan siswa. Untuk memperoleh data yang akurat, peneliti menggunakan metode penelitian eksperimen dengan desain eksperimen semu (Quasi Ekperiment). Berhubung subjek penelitian ini adalah peserta didik, maka penelitian ini adalah penelitian eksperimen semu dikarenakan akan ada faktor lain yang memengaruhi hasil penelitian yang berasal dari subjek penelitian itu sendiri. Populasi dalam penelitian ini adalah seluruh siswa SMP Al-Kamiliyyah Boarding School. Teknik pengambilan sampel dengan proporsive sampling. Teknik pengumpulan data dalam penelitian ini menggunakan angket dan instrumen penilaian keaktifan. Instrumen angket yang telah diuji validitas dan validitas konstruk sebanyak 22 pernyataan. Sedangkan analisis data menggunakan tabel empat pengkategorian, kemudian dianalisis secara deskriftif. Hasil dari data penelitian yang telah dihitung menggunakan software SPSS version 21 didapat, kelas eksperimen (VII E) menghasilkan rata-rata pretest 63,38 dan post-test 76,57 diperoleh gain sebesar 0,229 artinya mengalami peningkatan dengan kategori Low. Pada kelas kontrol diperoleh rata-rata pretest 61,52 dan post-test 63,67 dengan hasil analisa gain -0,411 yang artinya tetap ada peningkatan dengan kategori Decrease. Dengan demikian, penerapan model pembelajaran generatif dalam mata pelajaran IPS memberikan pengaruh pada tingkat keaktifan siswa dengan kategori low.
Pendidikan Nilai dari Karakter Sutan Syahrir
Authors: Fauzi Wildan Insan , Yulianti Iing , Parawita Firizki
Published: May 2022

Latar belakang penelitian ini didasarkan pada pentingnya penggalian karakter tokoh bangsa yang diperuntukan untuk generasi muda yang sedang dalam proses mencari jati diri. Mereka memerlukan “contoh” yang akan dijadikan model dalam membangun kepribadiannya. Pendidikan Nilai dari tokoh tokoh bangsa tersebut memberi bantuan terhadap peserta didik agar menyadari dan mengalami nilai-nilai serta menempatkannya secara integral dalam keseluruhan hidupnya. Batasan utama masalah penelitian ini adalah “nilai-nilai apa saja yang dapat digali dari kehidupan Sutan Syahrir untuk dapat dikembangkan dalam pembelajaran sejarah[”?. Penelitian ini menggunakan pendekatan historis dan analisis isi untuk mendapatkan gambaran mengenai karakter Sutan Syahrir. Terdapat delapan buku yang ditelaah yang menulis biografi Syahrir, antara lain karya Anwar (2011), Firdaus (2015), Indro (2009), Legge (2003), Masyhudi (1997), Mrazek (1996), Romandhon (2018), dan Santoso  (2014). Analisis kajian sejarah Sutan Syahrir memberikan gambaran mengenai pendidikan, idealisme dan kepemimpinan, sikap pemalu dan pendiam, diplomat ulung, percintaan dan hubungan sosial, perilaku kebarat-baratan dan kecintaan pada seni, konflik dengan Seokarno, serta keaktifan di organisasi.
Eksperimen Snowball Throwing Pada Materi Usaha Makro dan Mikro Mata Pelajaran Produk Kreatif dan Kewirausahaan
Authors: Fajri Yoan Nur , Hapsari Sri
Published: May 2022

Guru perlu mengembangkan metode pembelajaran yang dapat mendorong siswa untuk aktif, terampil, kreatif dan inovatif. Salah satu metode pembelajaran yang sesuai dengan tujuan pembelajaran tersebut yakni metode kooperatif tipe snowball throwing karena metode pembelajaran ini berpusat pada siswa. Snowball throwing sebagai salah satu tipe metode pembelajaran kooperatif merupakan pembelajaran yang diadopsi pertama kali dengan menggabungkan permainan fisik dengan diskusi. Snowball throwing melatih siswa untuk lebih tanggap menerima pesan dari siswa lain dalam bentuk bola salju yang terbuat dari kertas. Dalam prakteknya, siswa dapat mengajukan pertanyaan dan mengemukakan pendapat dalam sebuah pemikiran dengan kreativitas yang dimilikinya maupun kelompok. Tujuan penelitian untuk mengetahui ada tidaknya perbedaan hasil belajar produk kreatif dan kewirausahaan dengan menggunakan snowball throwing dan konvensional. Penelitian dilakukan pada siswa kelas XI SMK dengan menggunakan eksperimen, yakni adanya pemberian treatment berupa penggunaan snowball throwing pada pembelajaran. Pengumpulan data dilakukan dengan observasi dan pemberian tes pada kelas kontrol dan eksperimen. Hasil penelitian menunjukkan nilai rata-rata hasil belajar kelas eksperimen lebih tinggi dibandingkan dengan kelas kontrol.
Improving Follow-Up for Adolescents With Depression in Primary Care
Authors: Garbutt Jane , Dodd Sherry , Rook Shannon , Graham Sharon , Wang Ruoyun , Sterkel Randall , Plax Katie
Published: May 2022

BACKGROUND

Few adolescents with depression receive treatment in accordance with national guidelines. This quality improvement project took place in 11 primary care practices with the primary aim of increasing the percentage of teens with depression who received follow-up care within 6 weeks of diagnosis and within 3 months, once stable.

METHODS

The primary strategy was external practice facilitation for 12 months. The change process used goal setting and plan-do-study-act cycles to identify and implement change ideas. A preanalysis and postanalysis was completed to evaluate process change, provider confidence, and patient improvement.

RESULTS

Randomly selected samples of 199 and 217 charts of teens newly diagnosed with depression were reviewed before and after the intervention, respectively. Chart data for these measurements was provided by 10 and 9 practices, respectively. The percentage of patients with follow-up care within 6 weeks after diagnosis increased from 40% to 81% (P < .001), the percentage with a follow-up visit within 3 months once stable increased from 30% to 60% (P < .001), and the percentage in remission at 6 months increased from 7% to 21% (P < .001). Providers reported increased confidence to diagnose and manage depression, assess severity, provide pharmacotherapy, and educate families.

CONCLUSIONS

Practices improved follow-up care for teens with depression. In addition, providers experienced an improvement in their confidence to diagnose and manage depression. Working with a facilitator, each practice implemented standardized systems to provide effective care in the medical home, increase providers’ confidence to address this common problem, and improve patient outcomes.
Pediatric ICU Admissions After Adolescent Suicide Attempts During the Pandemic
Authors: Bruns Nora , Willemsen Lea , Stang Andreas , Kowall Bernd , Holtkamp Katharina , Kamp Oliver , Dudda Marcel , Hey Florian , Hoffmann Florian , Blankenburg Judith , Eifinger Frank , Fuchs Hans , Haase Roland , Baier Jan , Andrée Clemens , Heldmann Michael , Maldera Vanessa , Potratz Jenny , Kurz Daniel , Mand Nadine , Doerfel Claus , Rothoeft Tobias , Schultz Michel , Ohlert Manuel , Silkenbäumer Katrin , Boesing Thomas , Indraswari Fithri , Niemann Frank , Jahn Peter , Merker Michael , Braun Nicole , Nunez Francisco Brevis , Engler Matthias , Heimann Konrad , Brasche Milian , Wolf Gerhard , Freymann Holger , Dercks Martin , Hoppenz Marc , Felderhoff-Müser Ursula , Dohna-Schwake Christian
Published: May 2022

BACKGROUND AND OBJECTIVES

The worldwide severe acute respiratory syndrome coronavirus 2 pandemic challenges adolescents’ mental health. In this study, we aim to compare the number of pediatric ICU (PICU) admissions after suicide attempts during the first German lockdown and one year later during a second, prolonged lockdown with prepandemic years.

METHODS

A retrospective multicenter study was conducted among 27 German PICUs. Cases <18 years admitted to the PICU because of accidents or injuries between March 16 and May 31 of 2017 to 2021 were identified based on International Classification of Diseases, 10th Revision codes (German modification) and patient data entered into a database. This study is a subset analysis on suicide attempts in adolescents aged 12 to 17.9 years. The Federal Statistics Office was queried for data on fatal suicides, which were available only for 2020 in adolescents aged 10 to 17.9 years.

RESULTS

Total admissions and suicide attempts declined during the first lockdown in 2020 (standardized morbidity ratio 0.74 (95% confidence interval; 0.58–0.92) and 0.69 (0.43–1.04), respectively) and increased in 2021 (standardized morbidity ratio 2.14 [1.86–2.45] and 2.84 [2.29–3.49], respectively). Fatal suicide rates remained stable between 2017 to 2019 and 2020 (1.57 vs 1.48 per 100 000 adolescent years) with monthly numbers showing no clear trend during the course of 2020.

CONCLUSIONS

This study shows a strong increase in serious suicide attempts among adolescents during the course of the pandemic in Germany. More research is needed to understand the relation between pandemic prevention measures and suicidal ideation to help implement mental health support for adolescents.
Immunohistochemical subtypes of the breast cancer in the ultrasound and clinical
aspect – literature review
Authors:   Radiology Department II, Maria
            Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland, Dobruch-Sobczak Katarzyna , Gumowska Magdalena ,   Radiology Department II,
            Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw,
            Poland, Mączewska Joanna ,   Department of Nuclear
            Medicine, Medical University of Warsaw, Warsaw, Poland, Kolasińska-Ćwikła Agnieszka ,   Department of Oncology and
            Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw,
            Poland, Guzik Paweł ,   Department of Gynecology and
            Obstetrics, City Hospital, Rzeszow, Poland
Published: May 2022

Breast cancer is a heterogeneous disease both in its clinical and radiological
manifestations and response to treatment. This is largely due to the polymorphism of the
histological types as well as diversified molecular profiles of individual breast cancer
types. Progress in the understanding of the biology of breast cancer was made with the
introduction of immunohistochemical research into the common practice. On this basis,
four main breast cancer subtypes were distinguished: luminal A, luminal B, HER2 positive
(human epidermal growth factor receptor-2 positive), and triple negative cancer. The
classification of a tumour to an appropriate subtype allows for the optimisation of
treatment (surgery or pre-operative chemotherapy). In this study, the authors present
different patterns of breast cancer subtypes in ultrasound examination and differences
in their treatment, with particular emphasis on aggressive breast cancer subtypes, such
as triple negative or HER2 positive. They can, unlike the luminal subtypes, create
diagnostic problems. Based on multifactorial analysis of the ultrasound image, with the
assessment of lesion margins, orientation, shape, echogenicity, vascularity, the
presence of calcifications or assessment by sonoelastography, it is possible to
initially differentiate individual subtypes.
Critical reflections on ethnographic data collection in the highly gendered environment of male football
Authors: Wolfers-Pommerenke Solvejg
Published: May 2022

This article critically reflects on the methodological implications of indexing gender and sexuality by research participants when conducting ethnographic fieldwork in explicitly gendered contexts, particularly where notions of hegemonic masculinity are prevalent. Research suggests a number of potential challenges for female researchers, such as being patronised and subjected to sexist attitudes, among others. In order to gain a greater understanding of these methodological challenges, this study draws on over 60 hours of audio-recorded and observed interactions among male professional and elite football (‘soccer’ in US English) players and coaches before, during and after football matches and trainings. The main focus is the kinds of gendered and sexualised identities participants regularly assign to the female researcher in discursive interaction. This shows that, in ethnographic research projects, the construction of gender and sexual identities is potentially always relevant to data collection and research outcome.

In diesem Artikel werden die methodischen Implikationen der Indizierung von Gender und Sexualität durch Forschungsteilnehmer in ethnografischer Feldforschung in explizit gegenderten Kontexten, wo Vorstellungen von hegemonialer Männlichkeit vorherrschen, kritisch reflektiert. Die Forschung deutet diesbezüglich auf eine Reihe potenzieller Herausforderungen für weibliche Forscherinnen hin, unter anderem, Bevormundung und sexistischer Umgang. Um diese methodischen Herausforderungen besser zu verstehen, stützt sich diese Studie auf über 60 Stunden Audioaufzeichnungen und Beobachtungen von Interaktionen zwischen männlichen Profi- und Elite-Fußballspielern und Trainern vor, während und nach Fußballspielen und Trainingseinheiten. Es geht in der Studie vor allem darum, welche Art von gegenderten und sexualisierten Identitäten die männlichen Teilnehmer der weiblichen Forscherin regelmäßig in diskursiven Interaktionen zuordnen. Dies zeigt, dass in ethnografischen Forschungsprojekten die Konstruktion gegenderter und sexualisierter Identitäten potenziell immer relevant für die Datenerhebung und das Forschungsergebnis ist.
Virtual Activism: Sexuality, the Internet, and a Social Movement in Singapore Robert Phillips
Authors: Go Christian
Published: May 2022

Virtual Activism: Sexuality, the Internet, and a Social Movement in Singapore Robert Phillips (2020) University of Toronto Press, 180 pp.
A CONSTRUÇÃO CONCEITUAL DA PRÁXIS DA TOLERÂNCIA NOS PRESSUPOSTOS DE PAULO FREIRE
Authors: Conti Phiama Souza Guerra de , Paula Lucimara Cristina de
Published: May 2022

Este artigo apresenta parte dos resultados de uma pesquisa bibliográfica em que tem como objeto de estudo conceitual da construção conceitual nos conceitos de referência de Paulo. A pesquisa está pautada nos procedimentos indicados por Salvador (1978), Triviños (1987) e Minayo (1994). Os objetivos delimitados para este foram: o princípio da tolerância em Freire e evidenciar a contribuição da prática da proposta de Paulo Freire na construção de uma educação progressista, solidária, democrática e dialógica. A análise dos dados conforme o procedimento de Osgood apresentado por Bardin (2004).Os resultados da investigação indicam que a educação escolar para o processo de humanização escolar está intrinsecamente relacionada aos princípios fundamentais para uma educação com o processo de humanização. Sendo assim, o compromisso assumido com os princípios fundamentais e promovendo a adoção de outros princípios e hábitos para uma saúde saudável entre os sujeitos e com o mundo.
Psicodiagnóstico interventivo e o Teste de Apercepção Témática Infantil com Figuras Humanas: contribuições à clínica da adolescência
Authors: Chaves Gislaine , Salomão de La Plata Cury Tardivo Leila , Rinaldi Rosa Helena , Seixas Ferreira Loraine , Pinto Júnior Antonio Augusto
Published: May 2022

INTRODUÇÃO: O psicodiagnóstico interventivo, baseado nas Consultas Terapêuticas propostas por Winnicott, envolve, desde a primeira sessão, intervenções clínicas. Devido ao seu emprego em diferentes contextos e populações, instrumentos projetivos como o Teste de Apercepção Infantil com Figuras Humanas são utilizados para explorar e compreender o mundo vivencial, e aspectos relevantes da personalidade do público infanto-juvenil, subsidiando a atuação clínica com adolescentes. OBJETIVO: Apresentar a análise do psicodiagnóstico interventivo com o auxílio do teste por meio da ilustração clínica de um adolescente com comportamento de autolesão não suicida. MÉTODO: Trata-se de um estudo teórico-clínico, com delineamento de estudo de caso. Os dados foram analisados a partir da livre inspeção do material e à luz da abordagem psicanalítica winnicottiana. RESULTADOS: Evidenciou-se o principal conflito interno vivenciado pelo participante: submissão versus desejo de fazer o que é próprio para a idade, assim como autoimagem vulnerável e emprego de mecanismos primitivos de defesa diante do intenso sentimento de desamparo. CONCLUSÃO: O material clínico descrito apresenta a utilização do teste além de sua possibilidade diagnóstica, como mediador terapêutico, colaborando para aprofundar a queixa e oferecendo uma experiência de acolhimento e reflexão ao paciente, à semelhança da proposta do jogo de rabiscos de Winnicott, ou seja, estabelecendo contato com o campo emocional.
CLINICAL RESULTS AND PATIENT SATISFACTION OF TRANSOBTURATOR TAPE SURGERY IN PATIENTS WITH STRESS URINARY INCONTINENCE
Authors: BUHUR Ali , ÖNCÜ Necdet , ERDEM Dilek
Published: May 2022

Aim: In this retrospective study, we aimed to evaluate the surgical results, complications and patient satisfaction of the transobturator tape (TOT) operation in patients with stress urinary incontinence (SUI). Method: Incontinence type and duration, demographic information, menopause status, operation time , additional surgeries, preoperative and postoperative daily pad amount, Q type and stress test results, amount of residual urine after voiding, quality of life questionnaire Urinary Distress Inventory- 6 and Incontinence Impact Questionnaire-7 (UDI-6 and IIQ-7) results, intraoperative and postoperative complications of 156 patients were recorded. The success of the operation was evaluated in 3 groups as complete recovery, partial recovery and failure. Results: Complete or partial recovery was achieved in 146 patients (93.58%) after TOT operation. Success of operation was considered as failure in 10 (6.41%) patients. Complications were observed in 20 patients. These were bleeding more than 200 ml in 2 (1.28%), vaginal perforation in 2 (1.28%), de novo urge incontinence in 6 (3.84%), perineal pain in 2 (1.28%), dyspareunia in 2 (1.28%), mesh erosion in 4 (2.56%), urinary difficulty in 1 (0.64%), and bladder perforation in 1 (0.64%) patient. Conclusion: TOT procedure can be preferred as the surgical treatment of stress urinary incontinence, with high success and low complication rates, in line with the literature.
DETERMINATION OF HEALTH BEHAVIORS AND HAND HYGIENE PRACTICES OF HEALTH PERSONNEL WORKING AS A NURSE IN A TRAINING RESEARCH HOSPITAL AND HAVE DIAGNOSIS WITH COVID-19
Authors: MEŞE Aylin , ÇEVİRME Ayşe
Published: May 2022

Aim: This study was conducted to evaluate the health behaviors and hand hygiene practices of healthcare workers who have positive COVID-19 test and work as nurses before and after the pandemic. Materials and Methods: The study, which was descriptive and crosssectional, included 99 health personnel who worked as nurses at a training research hospital and tested positive for COVID-19. A questionnaire consisting of 55 questions in total, 25 questions about demographic information and 30 questions about health behaviors and hand hygiene practices, was directed to the participants. Results: 11% of the participants reported that they washed at least 10 times a day before the pandemic, 9.1% reported that they continued this washing practice for 20 seconds, and 5.1% reported that they participated in the training programs related to personal health and hygiene. Both pre-pandemic and post-pandemic rates in the same title are 86.9%, 90.9%, 68.7%, respectively. Conclusion: There was no difference in health behaviors and hand hygiene practices before and after the pandemic in healthcare workers. Despite this, improving the factors (more specific nutrition, good manpower planning, vaccination, etc.) related to the frequent catching of COVID
Getting started with Micro-Meta App Tutorial v2
Authors: Rigano Alessandro , Hammer Mathias , Ryan Joel , M. Brown Claire , Grunwald David , Strambio De Castillia Caterina
Published: May 2022

For quality, interpretation, reproducibility, and sharing value, microscopy images should be accompanied by detailed descriptions of the conditions that were used to produce them. Micro-Meta App is an intuitive, highly interoperable, open-source software tool that was developed in the context of the 4D Nucleome (4DN) consortium and is designed to facilitate the extraction and collection of relevant microscopy metadata as specified by the recent 4DN-BINA-OME tiered-system of Microscopy Metadata specifications. In addition to substantially lowering the burden of quality assurance, the visual nature of the Micro-Meta App makes it particularly suited for training purposes. In this protocol and in the associated videos (https://youtube.com/playlist?list=PLd2SsBj4SIsh7eE1M7l4v5_EsjUQcsfb0) you will learn how to get started using the Micro-Meta App for documenting your imaging experiments. Want to learn more? Please watch Video 1 of the Tutorial Series and read the publications listed in the References section of this protocol to learn more about the Micro-Meta App and the underlying 4DN-BINA-OME tiered system of Microscopy Metadata specifications.
CODEX® Multiplexed Imaging | Microscope Setup and Tissue Imaging v1
Authors: Saunders Diane , Reihsmann Conrad , Brissova Marcela , C. Powers Alvin
Published: May 2022

This protocol describes the imaging workflow currently in use by the Vanderbilt Diabetes Research Center Islet & Pancreas Analysis (IPA) Core and Powers/Brissova Research Group for CO-Detection by indEXing (CODEX®, now PhenoCycler™; Akoya Biosciences). See also CODEX® Multiplexed Imaging | Modality overview.
A simple technology for plastid transformation with fragmented DNA v1
Authors: Ren Kang , Jiang Chunmei , Zhang Jiang
Published: May 2022

A simple technology for plastid transformation with fragmented DNA
Scutellaria columnae All. (Lamiaceae), a new record for the flora of Turkey
Authors: TUNÇKOL Bilge , HAŞAYACAK Hasan
Published: May 2022

Plant specimens belonging to the Scutellaria genus of the Lamiaceae family were collected from Zonguldak (Ereğli), Bolu (Gölcük), Bartın (Ulus-Uluyayla), Kastamonu (Azdavay-Cide) and Sinop (Ayancık) provinces in the north of Turkey between 2018-2021. The collected plant samples were dried in accordance with herbarium techniques. After detailed herbarium studies and literature reviews, it was determined that this species does not take place in the flora of Turkey, and it is Scutellaria columnae All. With this new record added to the Scutellaria genus in our country, the number of taxa belonging to this genus in Turkey has increased to 41. In this study, there are descriptions, detailed photographs, and distribution areas of Scutellaria columnae, as a new species record for Turkey. With new studies to be carried out in different regions, it is thought that new endemic, natural and invasive species records will be added to the floristic richness of our country, which has not been fully revealed yet.
Expanding therapeutic opportunities for progressive uterine cancer: clinical experience
Authors: Kedrova A. G. , Krasilnikov S. E. , Berishvili A. I. , Zvezdkina E. A.
Published: May 2022

The incidence of uterine cancer in Russia increased by 28.8 % over the last 10 years. This trend is partly associated with an increasing prevalence of overweight and aging of the female population. Despite the fact that uterine cancer is limited to the uterine body in 84 % of cases, searching for new treatment regimens for patients with progressive disease is still relevant because of their poor outcomes of chemotherapy and high mortality among patients with stage III– IV cancer.

The aim of this study was to present our own view on the effectiveness of lenvatinib + pembrolizumab in patients with advanced or recurrent endometrial cancer on the basis of international and own experience.

The international experience with lenvatinib + pembrolizumab for advanced endometrial cancer without high microsatellite instability or impairments of DNA repair mechanisms after disease progression following previous systemic therapy showed their efficacy (38.3 %), while the effect lasting more than 6 months was observed in 69 % of cases. We report two cases of progressive uterine cancer in patients who developed complete clinical remission and demonstrated good tolerability of the therapy.
Results of single-stage two-stage reconstructive surgeries in young women with breast cancer
Authors: Ismagilov A. Kh. , Karasev V. E.
Published: May 2022

The leading position among cancer in women is breast cancer. The work analyzed the results of surgical treatment of 274 women aged 18 to 40 years with various stages of breast malignancy who underwent only a radical mastectomy (n = 141, group I), or a radical mastectomy with a single two-stage mammoplasty (n = 133, group II). The comparison group (n = 40, group III) was composed of healthy women after breast reconstruction based on aesthetic indications. When performing a mastectomy with subsequent one-time reconstruction, 68.4 % of cases achieved an excellent result, in 26.6 % of cases – good, in 4.5 % of cases – satisfactory, in 1.5 % – unsatisfactory. In women of group I, relapses of the disease developed 57.8 % more often, and metastasis – 1.9 times often, than in patients of group II. It was established that one-time reconstruction of the breast has a beneficial effect on the psycho-emotional state of women suffering from breast cancer, without increasing the risk of developing a relapse of the disease. The application of a two-stage technique of breast repair using tissue expanders in most cases allows achieving excellent cosmetic results.
Breast cancer in men. A case report
Authors: Kiseleva M. V. , Ivanov S. A. , Lunkova M. N. , Zharikova I. A. , Denisov M. S. , Litvyakova E. V.
Published: May 2022

Malignant breast tumors in men are quite rare and require deeper investigation. Men are 100 times less likely to develop breast cancer than women. However, its incidence among men has grown over the last few years. In this article, we describe own observations of breast cancer in males and report a case of ст1сN0M0 stage 1A cancer of the left breast in a man and provide the details of clinical and morphological disease characteristics, tumor immunohistochemistry, and treatment outcome.
Causes of resistance to PARP inhibitors and ways to overcome it. Case report of aggressive BRCA-related breast cancer
Authors: Stukan A. I. , Goryainova A. Yu. , Sharov S. V. , Goncharova O. A. , Khachmamuk Z. K. , Durov V. V.
Published: May 2022

PARP inhibitors. However, in clinical practice, despite the proven antitumor efficacy of drugs, acquired resistance to PARP inhibitors leads to difficulties in selecting further therapy due unknown resistance mechanisms and absence of algorithm of action. Despite the various mechanisms of resistance to PARP inhibitors, the choice of subsequent combination therapy after the detection of resistance to PARP inhibitors should be based on an understanding of these mechanisms and the existence of heterogeneous metastatic process. At the same time, it is very important to study the molecular and genetic characteristics of the disease at each stage of progression, which will help to identify the cause of resistance and select the optimal treatment strategy. It seems that liquid biopsy of circulating tumor DNA, detection of circulating tumor cells, circulating microRNA or exosomes may be more suitable methods of molecular diagnostics than repeated biopsies. Currently, there are data on the identification of two types of resistance to PARP inhibitors: mechanisms independent and dependent on the BRCA1/2 gene and homologous DNA recombination repair (HRR) mechanisms. Strategies for using combinations of different therapeutic regimens in conjunction with PARP inhibitors are very promising options for preventing treatment resistance in view of the increasing number of patients with similar clinical course of the disease.

In the presented clinical case, BRCA1-associated triple-negative breast cancer demonstrates an aggressive clinical course in case of adjuvant chemotherapy absence. Using the example of a clinical case, the effectiveness of therapy with the PARP inhibitor olaparib in disseminated BRCA1-mutated breast cancer, including those with brain metastases, was confirmed. At the same time, against the background of good tolerance and сlinical efficacy especially in the case of brain metastases, the use of the PARP inhibitor olaparib is a worthy alternative to chemotherapeutic regimens. The selection of subsequent therapy after a PARP inhibitor requires a balanced approach, taking into account the possible causes of crossresistance with chemotherapy regimens.
Psikolojik Sermaye Algıları Ölçeği: Bir Ölçek Geliştirme Çalışması
Authors: ATİLA Fulya , DÖNMEZ Burhanettin
Published: May 2022

Çalışmanın amacı üniversite öğrencilerinin psikolojik sermayelerine ilişkin algılarını belirlemeye yönelik geçerli ve güvenilir bir ölçme aracı geliştirmektir. Nicel araştırma yöntemlerinin kullanıldığı çalışma, İnönü Üniversitesindeki 1278 lisans öğrencisi ile gerçekleştirilmiştir. Çalışma sonucunda “Psikolojik Sermaye Algıları Ölçeği (PSAÖ)” geliştirilmiştir. Ölçek özyeterlilik boyutunda 4, umut boyutunda 4, psikolojik dayanıklılık boyutunda 5, iyimserlik boyutunda 4 madde olmak üzere 4 alt boyuttan ve toplam 17 maddeden oluşmaktadır. Ölçekte yer alan her madde, puan değeri olarak “1 = Beni Hiç Tanımlamıyor”, “2 = Beni Az Tanımlıyor”, “3 = Beni Orta Derecede Tanımlıyor”, “4 = Beni İyi Tanımlıyor”, “5 = Beni Çok İyi Tanımlıyor” seçeneklerinden oluşan, Likert tipi bir ölçek üzerinde değerlendirilmektedir. Ölçme aracından yer alan soruların tamamı olumlu ifadelerden oluştuğundan, alınan puanların artması üniversite öğrencilerinin psikolojik sermaye algılarının yüksek olduğunu, azalması ise üniversite öğrencilerinin psikolojik sermaye algılarının düşük olduğunu göstermektedir. 302 lisans öğrencisi ile yapılan Açımlayıcı Faktör Analizi (AFA) sonucunda ölçeğin Kaiser Mayer Olkin (KMO) değeri. 904 ve Bartlett testi sonucu anlamlı bulunmuştur. Varimax döndürmesi neticesinde elde edilen 17 madde ve 4 alt boyutlu ölçeğin toplam varyansın %58,93’ünü açıkladığı belirlenmiştir. 892 lisans öğrencisi ile yapılan ikinci düzey Doğrulayıcı Faktör Analizinde (DFA) ise : χ2=463.294, p=.000, sd=115, χ2/sd=4.029, RMSEA=0.058, NFI=0.91, CFI=0.93, GFI=0.94, RMR=0.037 bulunarak elde edilen yapı doğrulanmıştır. Cronbach Alpha iç tutarlılık katsayısı ise ölçeğin tümü için “.88” olarak hesaplanmıştır. Ölçeğin üniversite öğrencilerinin psikolojik sermaye algılarını belirlemek için kullanımının uygun olduğu söylenebilir.
A Study on Secondary School Students’ Foreign Language Anxiety: Students’ and Teachers’ Perceptions
Authors: ÖZSARI Tuğba , BÜYÜKKARCI Kağan
Published: May 2022

This study examines secondary school students’ and their teachers’ perceptions of foreign language anxiety. Also, the current study aims to compare public and private secondary school students’ foreign language anxiety level. Demographic variables such as gender and grades were also investigated to reveal whether they were acting as provoking or easing factors for foreign language anxiety among students. The sample group of this study consisted of 379 secondary school students chosen randomly and 9 English language teachers from public and private secondary school in Sakarya province, Turkey. The data were collected through two measurement tools, a scale for students and a questionnaire for teachers, which included open and close-ended questions. The quantitative data were analyzed through descriptive and inferential statistics, and for the qualitative data analysis, content analysis was conducted. The findings of the research revealed that public school students experience moderate level of foreign language anxiety, while private school students experience low level of foreign language anxiety. The findings of current study demonstrate that there is meaningful difference between public and private school students in terms of their foreign language anxiety. In both schools, females were more anxious than males; however, the difference between two gender groups was significant in private school. Grade was not a predicting factor for foreign language anxiety in the current study. However, in both schools, 8th graders are the most anxious group of all. As for the teachers, they were well aware of their students’ anxieties, and they implemented useful strategies for decreasing this anxiety. Also, they adapted their pedagogical instructions in order to reduce their students’ foreign language anxiety. However, research findings demonstrated that there was a discrepancy between teachers’ and students’ perceptions in terms of test anxiety.
Covid-19 Döneminde İngilizce Dersler İçin Sunulan Canlı Ders Kayıtlarına Yönelik Öğrenci Görüşleri
Authors: GÖKSEL Nil
Published: May 2022

Eğitim dünyasının son dönemde yüzleştiği Covid-19 gerçeği nedeniyle dünyadaki ve dolayısıyla Türkiye’deki birçok yüksek öğretim kurumu, acil uzaktan eğitime hızlı ve hazırlıksız bir geçiş yapmak zorunda kalmıştır. Bu süreç içinde normal şartlar altında uzaktan eğitim sistemi çerçevesinde planlanan ve yürütülen dersler, Covid-19 döneminde acil uzaktan eğitim adı altında kayıttan verilmeye başlanmıştır. Kayıt derslerin verimliliğini anlamak adına, gerçekleştirilen bu çalışma Açıköğretim Fakültesi öğrencilerinin Covid-19 döneminde İngilizce dersler kapsamında sunulan çevrimiçi canlı ders kayıtlarına yönelik öğrenci görüşlerini incelemeyi amaçlamaktadır. Betimsel tarama çalışması metodu ile yürütülen çalışmada, Açıköğretim Fakültesine kayıtlı A1 ve A2 İngilizce seviyelerine sahip 4088 öğrenciye web tabanlı bir anket uygulanmıştır. Çalışma konusuna yönelik elde edilen nicel veriler, frekans ve yüzde analizi gibi betimsel istatistik prosedürleri kullanılarak analiz edilmiştir. Araştırmanın bulgularına göre, Anadolu Üniversitesi Açıköğretim Fakültesi bünyesindeki A1-A2 düzeyinde İngilizce derslerini uzaktan tamamlamaya çalışan öğrenenler, pandemi dönemi boyunca kayıttan verilen derslere yönelik olumlu eğitsel deneyimlere sahip olmuşlardır. Bu bağlamda çalışma, AÖF öğrencilerinin kayıttan verilen dersleri anlamalarını etkileyen teknik, eğitsel ve psikolojik faktörlere yönelik görüşleri derlemiş ve geleceğe yönelik yapılacak diğer çalışmalar için öneriler sunulmuştur.
Öğretmenlerin Kaotik Liderlik, Örgütsel Yabancılaşma ve Örgütsel Mutluluk Algıları Arasındaki İlişkinin Yapısal Eşitlik Modellemesi ile İncelenmesi
Authors: DOĞAN Ümit , ASLAN Mahire
Published: May 2022

Bir örgütün devamlılığı ve etkililiğinde en önemli unsurlardan birisi işgörenlerin mutluluğudur. Ülkelerin geleceğine yön veren eğitim kurumlarında, bu misyonun gerçekleşmesi için anahtar rol oynayan öğretmenlerin mutlulukları ve mutluluklarına etki eden unsurların araştırılması önem arz etmektedir. Bu bağlamda örgütsel mutluluğa etki eden olgular olarak kaotik liderlik ve örgütsel yabancılaşma da araştırma kapsamına dâhil edilmiştir. 2020-2021 eğitim öğretim yılında Sakarya ili merkez ilçeleri olan Adapazarı, Erenler ve Serdivan’da görev yapan ilk ve ortaokul ile lise öğretmenleri, araştırmanın evrenini oluşturmaktadır. Araştırmanın örneklemi ise bu ilçelerdeki resmi okullarda görev yapan ve tabakalı örnekleme kullanılarak belirlenen 404 öğretmenden oluşmaktadır. Veriler; Örgütsel Yabancılaşma Ölçeği, Örgütsel Mutluluk Ölçeği ve Kaotik Liderlik Ölçeği aracılığı ile toplanmıştır. Verilerin analizinde Yapısal Eşitlik Modellemesi kullanılmıştır. Araştırma bulgularına göre öğretmenlerin, kaotik liderlik ile örgütsel yabancılaşma algıları arasında, negatif yönde anlamlı ve yüksek düzeyde bir ilişki; kaotik liderlik ile örgütsel mutluluk algıları arasında pozitif yönde anlamlı ve yüksek düzeyde ilişki; örgütsel yabancılaşma ile örgütsel mutluluk algıları arasında ise istatistiksel olarak negatif yönde anlamlı ve yüksek düzeyde ilişki olduğu tespit edilmiştir. Örgütsel yabancılaşmanın aracılık rolüne ilişkin olarak, kaotik liderliğin örgütsel mutluluğa etkisinde örgütsel yabancılaşmanın aracılık rolüne sahip olduğu, bu aracılık etkisinin ise orta düzeyde olduğu bulgusuna ulaşılmıştır.
Covid-19 Pandemi Dönemi Başlangıcında 1. Sınıfta Olan Öğrencilerin Bu Süreçlerinin ve 2. Sınıfa Hazırbulunuşluklarının Değerlendirilmesi
Authors: KOÇOĞLU Meltem , KASA AYTEN Başak
Published: May 2022

Bu araştırmada 2019-2020 eğitim öğretim yılında gerçekleşen Covid-19 pandemi dönemi başlangıcında 1. sınıfta olan öğrencilerin bu süreçlerinin ve 2. sınıfa hazırbulunuşluklarının değerlendirilmesi amaçlanmıştır. Nitel araştırma yaklaşımı benimsenmiş araştırmanın modeli durum çalışmasıdır. Ölçüt örnekleme yöntemiyle seçilen sınıf öğretmenlerinden ve velilerden gönüllülük esasına dayalı olarak görüş alınmıştır. Araştırmanın katılımcılarını Kayseri il merkezinde 2020-2021 eğitim öğretim yılında ikinci sınıflarda görevli, geçen dönem de aynı sınıfla eğitim yapmış sınıf öğretmenleri ve bu öğretmenlerin velileri oluşturmaktadır. Veri toplama aracı olarak yarı yapılandırılmış görüşme formu kullanılmıştır. Toplanan veriler içerik analizi yöntemiyle analiz edilmiştir. Araştırma sonucunda öğretmenlerin Covid-19 pandemi sürecinde uzaktan eğitime geçildiğinde ödevlendirmeden ve öğretmen-veli iş birliğinden yararlanmaya çalıştıkları belirlenmiştir. Öğretmenlere göre yazma becerisinin kazandırılmasında ve öğrencilerin sosyal gelişimlerinde uzaktan eğitimin yetersiz olduğu sonucuna varılmıştır. Öğretmenlerin yüz yüze ve uzaktan eğitimin birlikte sürdürülmesi şeklinde çözüm önerisi sundukları görülmüştür. Velilerin Covid-19 pandemi sürecinde uzaktan eğitime geçildiğinde EBA’dan ve veli-öğretmen iş birliğinden yararlanmaya çalıştıkları görülürken, uzaktan eğitime yönelik önerileri pandemi sürecinde uzaktan eğitimin devam etmesi ancak uzaktan eğitim içeriğinin zenginleştirilmesi şeklindedir. Pandemi sürecinde eğitimin daha sağlıklı yürütülmesi için öğretmenlere, öğrencilere ve velilere bu konuda psikolojik destek verilebileceği, öğretmenlere uzaktan eğitim, teknolojiler ve yapılabilecek etkinlikler konusunda hizmet içi eğitimler verilebileceği, teknolojik alt yapı ve donanım sağlanabileceği önerilerinde bulunulmuştur.
EXPERIMENTAL COMPARISON OF CONVOLUTION NEURON NETWORK ARCHITECTURES
Authors: Apeināns Ilmārs , Žukovs Vitālijs , Kodors Sergejs , Zarembo Imants
Published: May 2022

In this work, authors experimentally compare latencies of convolution neuron network architectures. Authors measured only recognition time. Four architectures were applied in the experiment: AlexNet, AlexNet Separated, MobileNetV1 and MobileNetV2. Models were trained using Fruits360 dataset. The Android mobile application was developed to measure latency on mobile devices. The smallest latency authors obtained using AlexNet Separable model, but the smallest size was provided by MobileNetV2.
SORTING ALGORITHMS REALIZATION AND THEIR FEATURES
Authors: Cabuļevs Ivars , Zorins Aleksejs
Published: May 2022

The performance of computers and programs is the most important thing for a user nowadays. Sorting algorithms appeared in the 19th century, but nowadays, developers often forget about the effectiveness of these algorithms and always use only a couple of algorithms, which are not always the best solution for certain tasks. This slows down the performance of certain important applications for professionals as well as for ordinary users. In this work was told and implemented different numerical sorting algorithms. The development environment here was “Microsoft Visual Studio 2017”. Was used the C++ programming language. Knowledge of sorting algorithms will always help you to optimize your program (if there used sorting), which will have a positive impact on user feedback about your application also this knowledge has a positive effect on the thought processes, allowing you to make the right decisions in the shortest time.
ERP SYSTEMS ANALYSIS AND DESCRIPTION OF SYSTEMS
Authors: Ludboržs Rihards , Grabusts Pēteris
Published: May 2022

In this article, I will briefly describe what business management systems are and what is that different from the others systems. Today, this system is called the “Enterprise Resource Planning Systems”. The purpose of this article is to look into the substance of the ERP systems and to identify the benefits of using the ERP systems.
ARTSS MODEL FOR SCIENTIFIC WORK MANAGEMENT
Authors: Ameļčenkova Liana , Sniedze Sandra , Kodors Sergejs
Published: May 2022

The digital age is characterized by quickly evolving and rapidly growing information, which must be analysed and considered in decision-making. Therefore, it is strongly important to see the current state of business in real-time having opportunity to analyse historical data and to predict future changes. The research work is specific business field with own contexts, aims and KPI. As a result, there is need of a digital twin to effectively manage research activities too.
OPTIMIZATION OF ENGINE CONTROL UNIT PARAMETERS
Authors: Āboliņš Dāvis , Grabusts Pēteris
Published: May 2022

The aim of this work is to change car’s engine control unit’s parameters on-the-go, to achieve more power or more fuel economy. To reach named aim author in this work analyzed common method of switching car engine control unit’s parameters by using normal computer and considered utilizing single board computer and making a built-in system to switch easily desired driving style on-the-go.
DEVELOPMENT OF ONLINE STORES SINCE COVID-19
Authors: Rozentāle Arta , Stafecka Līga , Nikolajeva Anna
Published: May 2022

The field of e-commerce became rapidly relevant already in 2019, when buyers, along with various prohibits to restrict the spread of Covid-19, switched to online shopping. The situation caused by Covid-19 demonstrated the benefits of e-commerce. During this time, e-commerce has grown and developed, and e-commerce now serves as a lifeline for many companies at a time when face-to-face sales were banned. During this time, more and more online stores have emerged, and more brands are fighting for the attention of consumers, thus consumers are forced to overtake online stores, including those who previously used only face-to-face shopping.
E-COMMERCE WEBSITES PERFORMANCE AND STABILITY ANALYSIS
Authors: Sadovska Tatjana , Sadovskis Dmitrijs , Grabusts Pēteris
Published: May 2022

The goal of the work is to make performance and stability analysis for the most popular e-commerce websites in Latvia, evaluate metrics and suggest improvements. Analysis result should provide necessary information for companies’ owners to increase conversion rate and reduce bounce rate.
IMPACT OF NO TILL TEHNOLOGY ON SOIL REGENERATIVE PROCESSES AND WEEDINESS
Authors: Avišāne Māra , Tretjakova Rasma
Published: May 2022

The paper reflects the importance of crop rotation and its impact on weeds, as well as the impact of plowing technology on regenerative processes. There are crops like oats, canola, beans that improve the soil, so they are good precursors. The cultivation of monocultures has been shown to lead to the degradation and reduction of soil organic matter. The paper investigates how the amount of weeds on a farm changes with the introduction of no till technology.
RESEARCH OF POSSIBILITIES OF LASER POLISHING OF THE SURFACE OF ALUMINUM
Authors: Bulavskis Kevins , Adijāns Imants , Lazov Lyubomir
Published: May 2022

The report considers the possibility of reducing the roughness after laser polishing of Aluminum plates. A CHANXAN CX-20G fiber laser with a wavelength of 1064 nm is used for the research. As a result of the experiment, 4 matrices were marked with a fiber laser on 3 samples for each series of the experiment. Then, using a multifunctional microscope, the roughness of the treated and untreated aluminum surface was measured. At the end of the research, conclusions were made about the changes in roughness in the course of this experiment.