bluuebunny/crossref_metadata_2025 huggingface dataset:
NILAI-NILAI PENDIDIKAN ISLAM DALAM TAYANGAN YOUTUBE CHANNEL POLISI MOTRET
Authors: Aidina Anisa Nikma , Wahyuni Mifta Khurohmah Tri
Published: July 2023

The quantity and quality of a person, including indicators of the value of Islamic education, is a significant development and becomes the basis for mental development in order to provide educational output in accordance with the expectations of the wider community. This is what shapes the personality of each individual with moral, ethical, and cultural values. On social media, researchers see creativity on YouTube channels with an entertaining genre. Therefore, the authors found the Polisi Motret channel with library research methods with entertaining genres but that do not abandon Islamic educational values. The main objective of the Polisi Motret channel research which is based on the value of Islamic education is to form the personality of the community so that it has ethical values that are in line with the principles of benefit and virtue in the form of the life principle of every Muslim who is faithful, pious, and has noble character in everyday life.Keywords:Â Value of Islam Education; YouTube Channel; Polisi Motret
MANAJEMEN KECEMASAN MASYARAKAT DALAM MENGHADAPI PANDEMI COVID-19
Authors: Putri Andini Permana Kartika , Septiawan Ardi
Published: July 2023

In the difficult conditions of the Covid-19 pandemic, people tend to experience anxiety. Anxiety is worrying about things out of control in the future. In anxiety management, there are three kinds of techniques, namely emotional regulation, cognitive behavioral techniques, and relaxation. Emotional regulation is a technique for balancing emotional states by changing the way emotions are expressed. CBT is a technique in which an individual's behavior and emotions can be controlled through a process of learning (cognition) and habituation (behavior). Finally, relaxation is a condition of resting the body by stretching, breathing, and taking a comfortable position so that the mind becomes calm and stable so that individuals can respond to these difficult conditions wisely. In this study, anxiety management is explored using a qualitative approach with literature study techniques.Keywords:Â Anxiety; Anxiety management; Cognitive Behavioral Thechniques; Emotion Regulation; Relaxation.
ANALISIS FAKTOR-FAKTOR KEPUTUSAN PEMBELIAN MAKANAN ONLINE MUSLIM MILLENIAL
Authors: Prasetiyawan Arian Agung , Nurhidayah Sela Mahribi
Published: July 2023

This research aims to find out the factors of online food purchasing decisions in young Muslims as a productive age group of internet users in Indonesia. This sample of research is a student of the Islamic Institute of Surakarta State. Then the study analyzed how halal awareness, curiosity, lifestyle, promotion, favorites, packaging, price and taste affect them in online purchases. The research method used is a mixture of quantitative and qualitative data. The source of this research data is obtained through the dissemination of questionnaires and semi-structured interviews with scoring analysis methods by rating the answers of respondents and drawing statement conclusions from interview answers. The results of this study make halal awareness a priority factor in making online purchases in order of halal awareness priorities; lifestyle; taste; packaging; curiosity; favorites; price; advertising and the majority of IAIN Surakarta students some 642 respondents noticed aspects of product halalness in online food purchases.Keywords:Â Purchasing Decision Factors; Food; Online Purchase; Muslim MillennialÂ
TOLERANSI NASARUDDIN UMAR SEBAGAI SOLUSI MENANGGULANGI RADIKALISME ATAS NAMA AGAMA
Authors: Fuady Farkhan , Rofiah Imanatur , Ningsih Selvia
Published: July 2023

Radicalism is synonymous with violence in carrying out its actions. Even today the radicalism movement in the name of religion as a vehicle to achieve their goals. There needs to be an effort to tackle radicalism in Indonesia. The effort is to instill religious tolerance. This study aims to examine the concept of tolerance according to Nasaruddin Umar. That in instilling a tolerant attitude is expected to be able to overcome radicalism. This study uses a qualitative method, with a literature review approach. Books, scientific articles, and other sources that are believed to be sources of research data. This study found that tolerance according to Nasaruddin Umar is respecting and respecting the rights of others. In implementing tolerance, he is committed to tackling radicalism in Indonesia. Several efforts were made to establish the Nasaruddin Umar Office and to promote the importance of tolerance in society through social media.Keywords: Nasaruddin Umar; radicalism; tolerance
STRATEGI PEMASARAN USAHA MIKRO KECIL MENENGAH DI MASA PANDEMI
Authors: Wardani Fatimah Sindi , Lestari Indah Puji , Sari Devinna Tamaya , Wulandari Ni'matul Umamah Tri
Published: July 2023

The Covid-19 pandemic has caused economic shocks that have had an impact on the global economy from the macro level to the global micro level. This pandemic has also dictated many economic and political policies, for example, layoffs and stay-at-home rules during this pandemic. This study aims to examine the effectiveness of online marketing to increase company revenue; Identify factors that influence online marketing strategies; and Provide alternative recommendations in online marketing strategies to be applied in Micro, Small, and Medium Enterprises (MSMEs). While the method used is a qualitative research method with a descriptive approach. This study establishes that social media is an effective marketing medium to promote MSME products, then the types of social media, product types and target markets are linear and empirical, meaning that each type has its own treatment and approach. specific one. The results of this study indicate that marketing strategy using social media is an effective way to maintain and increase the profit of MSME business results during the Covid-19 pandemic and this is line with social media theory.Keywords: MSMEs; Social Media; Promotional Mix; Target Market
STRATEGI PERTEMPURAN RADEN MAS SAID DI VORSTENLANDEN: SIKAP PATRIOTISME DALAM MENEGAKKAN KEADILAN
Authors: Atmojo Kuncoro Catur Setyo , Khofifah Nushrotul , Maharani Devi Nur
Published: July 2023

Raden Mas Said is a figure known in the Javanese saga as a figure who knows no fear. This figure once challenged three forces at once, namely the Surakarta Sunanate, the Dutch colonial, and the Yogyakarta Sultanate. The purpose of this study was to determine the fighting strategy of Raden Mas Said and his attitude towards the Kartasura Palace. This study uses the historical method with books, journals, and oral sources. The results of this study indicate that the battle strategy of Raden Mas Said is like eating jenang cartel porridge from the new edge to the middle, fighting from the new edge to the core and also using the Chakra Byuha battle title tactics which relies on its unity so as not to break and crush everything in its path. In front of him. This research is to complete.Keywords: Dutch Colonia; Struggle; Raden Mas Said.
Optimal sizing of a grid-connected microgrid and operation validation using HOMER Pro and DIgSILENT
Authors: Barco-Jiménez John , Córdoba Adrian , Escobar Rosero Edisson , Pantoja Andres , Caicedo Bravo Eduardo Francisco
Published: July 2023

Microgrids adoption around all world is increasing with different aims as to integrate renewable generation, providing energy to rural zones, reducing CO2 emissions, or simply as an alternative for energy independence. However, the planning and operation of microgrids can be a challenging task because it involves many economical, technical, environmental aspects. This work presents a methodology for planning and validating a grid-connected microgrid using two well-known software that facilitates the design. The planning process is performed in HOMER Pro to size and select appropriate generation sources, while the possible implementation on a real distribution network is validated in DigSILENT. Numerical results show the optimal sizing process of a grid-connected microgrid for a university campus based on real data and the technical validation based on Colombian regulatory aspects.
Sodium carbonate-promoted formation of 5-amino-1,2,4-thiadiazoles and 5-amino-1,2,4-selenadiazoles with elemental sulfur and selenium
Authors: Lin Jun-Xu , Liu Guo-Hui , Liu Li-Qiu , Wang Ying-Chun , He Yan
Published: July 2023

Sodium-carbonate-promoted green and facile synthesis of
5-amino-1,2,4-thiadiazoles and 5-amino-1,2,4-selenadiazoles with
elemental sulfur and selenium, respectively, was developed. This method
was carried out with O2 in the air as the green oxidant, and it has
several advantages, including low cost, low toxicity, and stable sulfur
and selenium sources, high atom efficiency with water as the sole
byproduct, simple operation, and broad substrate scope. Preliminary
mechanistic studies indicate that the formation of 1,2,4-thiadiazole
ring and 1,2,4-selenadiazole ring undergoes different processes.
Title: A Rare Case of Hermansky-Pudlak Syndrome
Authors: Kini Pushpa , Bhatia Aashna , Balasubramanian Rukmoni
Published: July 2023

Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder
characterised by oculocutaneous albinism, a bleeding diathesis and
platelet storage deficiency. The aim of this paper is to report a case
of a patient with HPS who was followed over a decade. A
2-and-a-half-year-old boy presented with recurrent respiratory tract
infections and
Two-year trajectories of COVID-19 symptoms and their association with illness perception: A prospective cohort study in Amsterdam, the Netherlands
Authors: Wynberg Elke , Verveen Anouk , Willigen Hugo van , Nieuwkerk Pythia , Davidovich Udi , Lok Anja , Jong Menno de , Bree Godelieve de , Leenstra Tjalling , Knoop Hans , Prins Maria , Boyd Anders
Published: July 2023

Background We used data from a prospective cohort to explore two-year
trajectories of “long COVID” (persistent symptoms after SARS-CoV-2
infection) and their association with illness perception. Methods
RECoVERED participants (adults; prospectively enrolled following
laboratory-confirmed SARS-CoV-2 infection, May 2020-June 2021) completed
symptom questionnaires at months 2-12, 18 and 24, and the Brief Illness
Perception Questionnaire (B-IPQ) at months 1, 6, and 12. Using
group-based trajectory models (GBTM), we modelled symptoms (mean total
numbers and proportion with 4 specific complaints), including age, sex,
BMI and timing of infection as covariates. In a multivariable linear
mixed-effects model, we assessed the association between symptom
trajectories and repeated B-IPQ scores. Results Among 292 participants
(42% female; median age 51 [IQR=36-62]), four trajectories were
identified, ranging from Trajectory 4 (8.9%; 6+ symptoms) to Trajectory
1 (24.8%; no symptoms). The occurrence of fatigue and myalgia increased
among 23% and 12% of participants, respectively. Individuals in
Trajectory 4 experienced more negative adjusted B-IPQ scores over time
than those in Trajectories 1-3. Conclusions We observed little
fluctuation in the total number of symptoms but individual symptoms may
develop as others resolve. Reporting a greater number of symptoms was
congruent with more negative illness perception over time.
Holotoxin A1 from Apostichopus japonicus inhibited oropharyngeal and intra-abdominal candidiasis by inducing of oxidative damage in Candida albicans
Authors: Liao Min , Xia Xuekui , Meng Qingzhou , Zhu chengguang , Liao Binyou , Wang Jiannan , Gou Lichen , Zhou Xuedong , Yuan Wenpeng , Cheng Lei , Ren Biao
Published: July 2023

Background and Purpose: The holotoxin A1, isolated from Apostichopus
japonicus, has shown potent antifungal activities with unclear mechanism
and efficacy against candidiasis. This study aimed to reveal the
antifungal effects and mechanism of holotoxin A1 against Candida
albicans in vitro and in candidiasis murine models for the first time.
Experimental Approach: The antifungal effect of holotoxin A1 against C.
albicans was tested in vitro. To explore the antifungal mechanism of
holotoxin A1, the transcriptome, ROS levels, and mitochondrial function
of C. albicans was evaluated. The oropharyngeal and intra-abdominal
candidiasis mouse models were used to verify the effectiveness and
systematic toxicity in vivo. Key Results: Holotoxin A1 was a potent
fungicide against C. albicans SC5314, clinical strains and
drug-resistant strains. Holotoxin A1 inhibited the oxidative
phosphorylation and induced oxidative damage by increasing intracellular
accumulation of ROS in C. albicans. Holotoxin A1 caused the disfunction
of mitochondria by depolarizing the mitochondrial membrane potential and
reducing the production of ATP. Holotoxin A1 directly inhibited the
enzymatic activity of mitochondrial complex I (CI) and antagonized with
the rotenone, an inhibitor of CI, against C. albicans. Meanwhile, the CI
subunit NDH51 null mutants showed the decreased susceptibility to
holotoxin A1. Furthermore, holotoxin A1 significantly reduced fungal
burden and infections with no significant systemic toxicity in
oropharyngeal and intra-abdominal candidiasis murine models. Conclusions
and Implications: Holotoxin A1 was a promising candidate for the
development of novel antifungal drug against both oropharyngeal and
intra-abdominal candidiasis, especially caused by the drug resistant
strains.
MICROMORPHOLOGICAL AND PHYTOCHEMICAL PROFILING OF DELPHINIUM SUAVE HUTH. FROM HINDUKUSH RANGE, LOWER DIR KHYBER PAKHTUNKHWA PAKISTAN
Authors: Ahmad Imran , Dastagir Dr.Ghulam
Published: July 2023

This is a very first attempt to study various parameters of a medicinal
plant, Delphinium suave Huth. The plant is erect, geophytic,
herbaceous, with tuberous root, trifid in a palmatipartite, strigose
cuneate leaf and white spurred zygomorphic flower. The root was
isodiametric phellem with single non-glandular trichomes. The stem
revealed single-layered cuticle, multiseriate epidermis, cortex, pith
ray and uniserate bowed non-glandular trichomes. The leaf was
amphistomatic, showed tapering trichomes, prismatic crystals and
ranunculaceous stomata with circumference 144.66-182.67 µm. Pollen
grains in Light Microscopy (LM), were prolate, spheroidal
trizonocolpate, isopolar, radiosymmetric, scabrate, elliptic and monads.
Scanning Electron Microscope (SEM) pollen surface was scabrate, monad,
size varied from 18.06 µm-16.67µm, colpus to inaperturate, tricolpate,
ornamented, echinus, isopolar, isodiametric and circular. SEM roots
showed sclerenchymatic tissues, stellate, glandular, non-glandular
trichomes and crystals. The stem showed scalariform, pitted vessels,
warty protuberances, unicellular, silicified, non-glandular trichomes.
Leaves powder revealed, simple, unicellular, tapered headed, uniseriate,
sessile, capitate, unbranched glandular, non-glandular, trichomes with
crystals. Capitate, stellate, circular, unicellular, branchy trichomes
were observed for the first time through SEM. Powder drug study of root,
stem leaves through LM also revealed different tissues. Preliminary
phytochemical revealed alkaloids, anthocyanins, anthraquinones,
coumarins, flavones, mucilages, saponins, steroids, terpenoids, volatile
oils and proteins. GC/MS showed 36 compounds in roots 33 in stem while
41 in leaves. Fluorescence analysis of roots, stem and leaves showed
variation in colour when treated with chemicals. This study will assist
pharmacognostic exploration, authentication from adulterants/allied
species for consistent quality, resulting in safe use, preservation and
efficacy.
A Study on the Educational Implications and Direction of Princess Bari's Myth, the Oral Literature as a Cultural Content for Early Childhood Education
Authors:   The Korea Associantion For Early Childhood Education Administration, Yoo Seung-Yoeun
Published: July 2023

It is meaningful for modern people to face the crisis of self-loss and division to reflect on their inner selves through myths that contain the original image of humans. As Jung said, mythology has been the inspiration for numerous growth and creation.
Therefore, it is encouraging that numerous narratives from oral literature, which is based on mythology have recently been reproduced into various forms of cultural contents in the field of early childhood education. However, infants lack in the cognitive ability to understand the gap between time and culture, so when producing cultural content for infants, young infants should be considered to be able to contact themselves smoothly and safely without being overwhelmed by the mythical rough primitives. At this time, adults, including teachers who guide infants, should not just reproduce the story, but develop mythical background knowledge, open attitudes, and creative thinking.
Therefore, this study puts emphasis on some examples of educational meanings and implications that infants can experience in using the narrative of Princess Bari's story as a cultural content for early childhood education. In addition, cases of issues related to the confrontation of values that infants may be confused from a modern point of view were discussed. This study is in line with Jung's view of presenting the “secret growth movement of mythical representations” as a way to find answers to the problems at hand as well as growth and integration within humans.
The effect of parental parenting attitudes on infant self-determination: Mediating effect of infant resilience
Authors:   The Korea Associantion For Early Childhood Education Administration, Lee Sung-Hee , Park Jong-Woo
Published: July 2023

This study attempted to examine the relationship between affection, rejection, and protection of parental parenting attitudes on infant self-determination through infant resilience. To this end, a survey was conducted on 315 parents of 4-5-year-old infants enrolled in kindergartens and daycare centers at institutions in Gyeonggi-do, and 304 copies of the 315 copies were analyzed, excluding unfaithful data. Source: SPSS 22 was used for data processing. The results of this study are as follows.
First, it was discovered that parental parenting attitudes' affection had a static impact on infant resilience, and parental parenting attitudes' rejection and overprotection had a negative impact.
Second, infant resilience had a positive effect on infant self-determination.
Third, the affection of parental parenting attitudes had a positive effect on infant self-determination, and the rejection and overprotection of parental parenting attitudes had a negative effect on infant self-determination.
Fourth, as a result of examining the mediating effect of infant resilience in the relationship between parental attitude and infant self-determination, infant resilience partially mediated in the relationship between infant self-determination and overprotection of parental attitude. This means that infant resilience acts as a factor that can increase infant self-determination in the effect of parental parenting attitude on infant self-determination.
Repeated treatment with lidocaine/prilocaine cream (EMLA) as a topical anaesthetic for the cleansing of venous leg ulcers. A controlled study.
Authors: Hansson C , Holm J , Lillieborg S , Syrén A
Published: July 2023

Repeated topical analgesia with EMLA 5% cream prior to the cleansing of venous leg ulcers was studied. Patients were randomly allocated to a series of 8 treatments with EMLA (n = 22) or to a control group (n = 21). A thick layer of the cream was applied to the ulcers for 30 min. At each of the 8 treatments, local reactions were assessed on a 4/point scale and pain from ulcer cleansing on a visual analogue scale. At the first and the last treatment the area of the ulcer was determined by mapping, a sample for a bacterial culture was taken and the amount of dead tissue, slough and granulation tissue present was assessed. Treatment with EMLA for 30 min significantly decreased the pain from cleansing of the leg ulcers and the frequency of post/cleansing pain. The analgesic effect remained unchanged with successive treatments. Repeated treatment with EMLA in leg ulcers would appear to be safe, as indicated by the absence of any serious untoward events. No statistically significant differences in local reactions or adverse effects on granulation tissue, ulcer area or bacterial flora were observed in the EMLA/treated patients compared with the control patients.
Serum aminoterminal propeptide of type III procollagen in systemic sclerosis. A follow-up--investigations in subclasses and during therapy.
Authors: Heickendorff L , Parvez A , Bjerring P , Halkier-Sørensen L , Zachariae H
Published: July 2023

Fifty-seven patients with systemic sclerosis were investigated for connective tissue turn-over related to type III collagen. Sera from 13 patients with diffuse cutaneous systemic sclerosis and 44 patients with limited cutaneous systemic sclerosis were analysed for aminoterminal propeptide of type III procollagen (PIIINP) by a radioimmunoassay based on human propeptide. Increased levels of PIIINP in serum correlated with skin involvement and the clinical course. All patients with diffuse cutaneous systemic sclerosis had levels above the normal range, and in limited cutaneous systemic sclerosis elevated PIIINP levels seemed to be correlated with rapid progression and with extension of lesions. Immunosuppressive drugs, cyclosporin A, and prednisone with or without cyclophosphamide, which were given to patients with rapid disease progression, significantly reduced PIIINP. This was also the case with penicillamine, but to a lesser degree. Our data support the suggestion that immunosuppressive agents are justified in rapidly progressive, life-threatening or disabling disease, when used with the necessary precautions. Serum PIIINP may be utilized as a marker of type III collagen fibrogenesis in systemic sclerosis and be of prognostic value. PIIINP may also be of use in the differential diagnosis between diffuse cutaneous systemic sclerosis and scleredema.
Inhibition of basal cell proliferation during storage of detached cultured epidermal keratinocyte sheets.
Authors: Poumay Y , Boucher F , Degen A , Leloup R
Published: July 2023

Grafting of human cultured keratinocytes is a promising possibility for the treatment of large burned skin areas. However, during the preparation of cultures for grafting, a necessary step of detachment from culture substratum is performed by incubation with Dispase. In the present paper, we report studies performed to determine whether prolonged storage after detachment would have a detrimental effect on keratinocyte proliferation. Our results show that the number of bromodeoxyuridine-incorporating cells located in the basal layer of the culture gradually diminishes during storage of detached cultured epidermal keratinocyte sheets. Furthermore, the rate of [3H]thymidine incorporation in such detached cultures is also progressively reduced. These observations indicate that the detachment and storage of cultured epidermal keratinocyte sheets for grafting impedes their cell proliferation capacity, as revealed by DNA-synthesis measurements.
Familial hypotrichosis of the scalp. Autosomal dominant inheritance in four generations.
Authors: Ibsen H H , Clemmensen O J , Brandrup F
Published: July 2023

We describe a Danish family of four generations suffering from hypotrichosis of the scalp. Age at onset was 6-17 years and almost total scalp alopecia was reached by the age of 14-21 years. No associated ectodermal defects were present. Nine of 22 persons covering four generations were affected. Growth of the scalp hair slowly decreased and was accompanied by a gradual, diffuse hair loss without regional variation. A scalp biopsy was performed, revealing a non-scarring alopecia with features of androgenetic alopecia. The pedigree was compatible with autosomal dominant inheritance.
RNA purification from epidermal suction blisters.
Authors: Kristensen M , Larsen C G , Jørgensen P , Paludan K
Published: July 2023

Certain inflammatory skin diseases are accompanied by increased cytokine concentrations in the epidermis. To determine whether these cytokines are synthesized in the epidermis or exported from underlying tissues, epidermal RNA was analysed for the presence of their messenger RNAs. We report a method for RNA extraction from pure epidermal samples isolated by the suction blister method. The yield of total RNA was sufficient for hybridization experiments (12-38 micrograms per seven blisters, 5 mm in diameter). Using RNA extracted by this method, we have demonstrated the presence of messenger RNA for glyceraldehyde-3-phosphate-dehydrogenase in 13 preparations from suction blisters obtained from tuberculin skin reactions, positive patch test reactions, or normal skin. We did not, however, observe messenger RNA for interleukin 1 alpha or 8 in these preparations.
Juvenile tinea capitis caused by Trichophyton violaceum. Hepatic reactions during ketoconazole treatment.
Authors: Gasior-Chrzan B , Stenvold S E , Falk E S
Published: July 2023

A 10-year-old boy with T. violaceum tinea capitis was given systemic ketoconazole therapy. After 4 weeks' treatment, liver enzymes had increased considerably. Ketoconazole treatment was stopped and 3 weeks later the values had returned to normal. Three weeks thereafter the patient was completely cured and no relapses have occurred.
A report of two cases of pigmented purpuric dermatoses treated with PUVA therapy.
Authors: Wong W K , Ratnam K V
Published: July 2023

This is a report of 2 patients with pigmented purpuric dermatosis treated successfully with Psoralen photochemotherapy (PUVA). Treatment for pigmented purpuric dermatosis is generally unsatisfactory, and we believe this to be the first report of successful response of this condition to PUVA.
Fc gamma-receptors on Langerhans' cells and keratinocytes in suspension from normal skin characterized using soluble immune complexes and monoclonal antibodies.
Authors: Tigalonowa M , Bjerke J R , Matre R
Published: July 2023

Fc-receptors for IgG (FcR) on epidermal cells in suspension were studied using soluble immune complexes and monoclonal antibodies (MoAbs) against FcR I, FcR II and FcR III using an indirect immunofluorescence technique. The binding of immune complexes demonstrated that most Langerhans' cells (greater than 95%) and a proportion of keratinocytes (25 +/- 6%) expressed functional FcR activity. The reactivity with MoAbs showed that epidermal cells possess different types of FcR. Langerhans' cells reacted only with IV.3 (anti-FcR II/-CDw32). A varying percentage of keratinocytes reacted with 32.2 (anti-FcR I/-CD64) (18 +/- 10%), Leu 11b (anti-FcR III/-CD16) (19 +/- 6%) and B1D6 (against a placental FcR) (35 +/- 8%). Both with immune complexes and MoAbs the staining was strongest along the cell surface, but cytoplasmic staining was also regularly present. The data add further support to the contention that keratinocytes have an immune function. FcR on epidermal cells may play an immunoregulatory role interacting with isotypes and cytokines in the skin. Keratinocyte-produced soluble FcR could also be an immunological mediator.
A double-blind study of superficial radiotherapy in psoriatic nail dystrophy.
Authors: Yu R C , King C M
Published: July 2023

In a double-blind controlled study, superficial radiotherapy (SRT) was given to psoriatic fingernails as three fractionated doses of 150 cGy (90 kV, 5 mA, 1.00 mm aluminium filter). The treated nails demonstrated a significant fall in scoring on a clinical rating scale 10 and 15 weeks after therapy (mean scores = 4.4 and 4.6 respectively) when compared with a mean pretreatment score of 5.5 at week 0 (p less than 0.0001 and p less than 0.05 respectively) the treated nails also showed significant clinical improvement when compared with the sham-treated nails at weeks 10 and 15 (p less than 0.05). Mean nail thickness in treated nails 15 weeks after therapy was significantly thinner (mean thickness = 0.75 mm) than that of sham-treated nails (0.88 mm, p = 0.005), but the difference was not significant at week 20. The rate of linear nail growth was unaffected. SRT appears to confer a definite albeit temporary benefit on psoriasis of the nails at this dosage.
Psoriasiform acral dermatitis. Report of three cases.
Authors: Tosti A , Fanti P A , Morelli R , Bardazzi F
Published: July 2023

The authors report 3 patients affected by psoriasiform acral dermatitis, a distinctive clinical entity characterized by a chronic dermatitis of the terminal phalanges, associated with marked shortening of the nail beds of the affected fingers. The skin biopsy showed in all cases the pathological features of a subacute spongiotic dermatitis. X-ray examination of affected fingers showed no bone or soft tissue changes. Differential diagnosis of psoriasiform acral dermatitis included psoriasis, atopic or contact dermatitis and corticosteroid-induced distal phalangeal atrophy.
Treatment of pityriasis versicolor with a single dose of fluconazole.
Authors: Faergemann J
Published: July 2023

Twenty-four patients with extensive or recurrent pityriasis versicolor were treated with a single oral dose of 400 mg of fluconazole. Twenty-three patients returned for follow up. Seventeen or 74%, were free of lesions 3 weeks after treatment and no recurrences were seen 6 weeks after treatment. The majority of the patients found the treatment effective, safe and convenient.
Alpha interferon treatment in atopic dermatitis.
Authors: Jullien D , Nicolas J F , Frappaz A , Thivolet J
Published: July 2023

Eight patients suffering from atopic dermatitis were treated with interferon alpha 2b. They received low or intermediate doses (9/15 x 10(6) U/week) for a short period of time (4/8 weeks), with a moderate improvement of skin lesions in 4 of them and no change or an exacerbation of the disease in the other 4. Among the 4 patients who slightly improved at 4 weeks, 3 did not show any beneficial effect of interferon after 8 weeks. Serum IgE levels, which were increased in all patients before treatment, were not reduced under interferon therapy. This study shows that intermediate doses of interferon alpha 2b are not effective in the short/term treatment of atopic dermatitis.
Behçet's disease: a review and a report of 12 cases from Sweden.
Authors: Ek L , Hedfors E
Published: July 2023

In a retrospective study of 12 patients with Behçet's disease, more than half were found to originate from the Near East, where the prevalence of the disease is known to be high. The immigrant patients were all males, whereas 3 of the 5 patients with Swedish ancestry were females. Certain differences emerged between the two groups, including different sex ratio and absence of HLA B5 association and pathergy skin reaction among the Swedish patients. Moreover, serious neurological and ocular symptoms showing no tendency to recede with age afflicted all the Swedish female patients. Urogenital symptoms were, besides ulcers, common in both groups, including prostatitis, urethritis, orchitis, chronic sterile cystitis and relapsing salpingitis. Although the maternal does not allow statistical inferences, the estimated prevalence was higher than expected among both Swedish and immigrant patients. Recent studies, including the diagnostic criteria proposed by the "International Study Group for Behçet's disease", are discussed in relation to previously used criteria as well as present findings. The sensitivity and specificity of the first mentioned criteria and the ones proposed by Mason & Barnes seemed equal.
Ano/genital warts in consecutive male heterosexual patients referred to a CO2/laser clinic in Copenhagen.
Authors: Sand Petersen C , Menné T
Published: July 2023

The relation between sexual practices and location of anogenital warts is discussed. Results were derived from clinical examination and interview of 56 consecutive male patients referred to CO2/laser treatment of therapy/resistant genital warts, at a clinic at the Department of Dermatovenereology, Gentofte Hospital, located in the northern area of Copenhagen. Twenty (100%) patients with anal warts and 36 (100%) patients with penile warts all claimed to be strictly heterosexuals. None of the patients interviewed had had anoreceptive coitus or been engaged in sexual practices with oro/anal contact. The study population otherwise had a heterosexual profile with approximately one fifth of the patients having had other sexually transmitted diseases, mainly chlamydia. The group of patients with anal warts had significantly fewer known sex partners with genital warts (25% versus 58%, p < 0.05) compared to the patients with penile warts. All patients received one or more CO2/laser treatments using local anesthesia, resulting in cure rates of 80% (16/20) and 89% (32/36) in men with anal warts and penile warts, respectively. Anal warts seem to be much more common in a heterosexual male population. There is a need to elucidate the nature and epidemiology of anal human papillomavirus infection in heterosexual males.
Erythema multiforme during GM-CSF therapy.
Authors: Stasi R , Gatti S , Perrotti A , Orlandi A , Spagnoli L G , Papa G
Published: July 2023

A 52-year-old Caucasian man treated with granulocyte-macrophage colonystimulating factor (GM-CSF) developed a cutaneous eruption on legs and ankles with clinical and histologic features of erythema multiforme. Laboratory studies indicated that the eruption occurred at the time of peripheral blood lymphocyte recovery and that it was coincidental with serum peaks of interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-6 (IL-6) and tumour necrosis factor-alpha. We postulate that GM-CSF provoked erythema multiforme in a predisposed individual as a consequence of either an inappropriate cytokine secretion or of an abnormal amplification mechanism following lymphocyte recovery.
Occlusivity and effects of two occlusive dressings on normal human skin.
Authors: Agren M S , Wijesinghe C
Published: July 2023

Two occlusive, adhesive dressings--one hydrocolloid (absorptive) and one zinc-medicated (non-absorptive)--were studied regarding their occlusivity and effects when applied to normal human skin for 48 h. Both dressings reduced normal transepidermal water loss by about 70%. As documented by a 7-fold increase in the water loss beneath the dressings compared to untreated skin, water was retained in the stratum corneum by both dressings. No appreciable influence of either dressing on skin temperature was found. The skin surface pH decreased beneath the hydrocolloid while it increased beneath the zinc dressing.
Pachydermodactyly: report of two cases.
Authors: Yanguas I , Goday J J , Soloeta R
Published: July 2023

Pachydermodactyly is a rare and benign form of digital fibromatosis with only a few cases described in the literature. We report two cases of pachydermodactyly affecting young men. In one of them a knuckle pad was found, and the fibromatous thickening of the skin affected not only the finger joints but also the dorsum of the hands. This case can be included in the particular clinical form named pachydermodactyly transgrediens.
Oral hairy leukoplakia: pathogenetic aspects and significance of the lesion.
Authors: Brehmer-Andersson E , Lucht E , Lindskog S , Ekman M , Biberfeld P
Published: July 2023

Oral hairy leukoplakia in HIV-seropositive persons is considered as a highly serious sign and places the patient in the AIDS-related complex group according to the classification recommended by the Centers for Disease Control. Epstein-Barr virus (EBV) is thought to be the cause. Based on the investigation of 14 of our own cases and a review of the literature, we conclude that so called hairy leukoplakia does not have a specific histopathologic pattern. Identical lesions can be caused by fungus infection, or biting and other kinds of mechanical irritation. Both fungal infection and EBV infection have been proven in a high percentage of the lesions. However, EBV has been found also in apparently normal oral mucosa. This questions the assumption that the virus is the cause of the lesions. In our investigation the presence of "hairy leukoplakia" did not reflect the clinical status of the patient. The best indicator of the clinical status was the T-lymphocyte subset CD4+ number in the peripheral blood. It appears that low CD4+ counts, candidiasis and the presence of replicating EBV in the epithelial cells are parallel markers of increasing immunodeficiency.
Impact de l’alignement stratégique et de la culture digitale sur la réussite de la transformation digitale au sein de l’organisation publique Marocaine
Authors:   Université Ibn Zohr, Agadir, Maroc, Ben Dahhane Anouar , Akrich Said , El Bettioui Rachid , Abdelkhalik Hicham ,   Université Ibn Toufail, Kénitra, Maroc
Published: July 2023

Digital transformation is currently a hot topic and a strategic issue for all public and private organizations, regardless of their size. Having entered the "digital era", organizations are facing unprecedented transformations that disrupt their operations and management systems. However, the concept is new and it is not yet clear what factors influence or boost digital transformation. While previous theoretical and empirical work has allowed us to identify the impacts on the success of Digital transformation of the strategic alignment between the digital technologies implemented and the strategy of the public or private organization. Also, we have revealed that the digital culture is the guarantee of strategic coherence and success of the organization's digital transformation. The aim of this research project is to study the extent to which digital technology deployment projects are strategically aligned with the organization's overall strategy, and the degree to which digital culture impacts digital transformation within the organization. We mobilized a quantitative method by means of a questionnaire. A total of 52 respondents from the central entities of the Caisse Nationale de Sécurité Sociale (CNSS) completed the questionnaire. These were managers and executives involved in digital transformation initiatives. The theoretical model was tested using structural equation modeling. Analysis of the data collected using SMART PLS V4 highlights the crucial role of the CNSS establishment's strategy in value creation and the success of digital transformation. The results also indicate that to fully seize the opportunities and potential of this transformation, it is essential to embed a digital-focused organizational culture. In fine, the two hypotheses mobilized at the outset of the positive impact of strategic alignment and digital culture on the success of digital transformation are validated.
Le capital humain, l’employabilité et l’entrepreneuriat : Cas du Programme d’Insertion par les Activités Economiques
Authors:   Université Ibn Zohr, Agadir, Maroc, El Bettioui Rachid
Published: July 2023

Vocational training and employability are essential levers for regional and local development, and could therefore play a significant role in developing entrepreneurship and integrating young people into the economic fabric. Indeed, the issue of employability represents a barrier to regional development in Morocco, particularly in the southern provinces. Unemployment is exacerbated by the loss of jobs and the stoppage of production as a result of the COVID-19 crisis. In this vein, this article looks at the problem of employability and integration of young graduates in these regions of southern Morocco. The aim of this work is to highlight the role of OFFPT's vocational training and its partners in the development of employability and local socio-economic development in the southern provinces, and more specifically in the province of Sidi Ifni in the Guelmim Oued Noun region. Within this framework, a descriptive study was carried out among young entrepreneurs who had benefited from vocational training and the "PIAE" economic activity integration program. A descriptive analysis of the data, collected from local public players and a sample of young graduates, was carried out to examine the contribution of vocational training to their employability and well-being. The results of our research revealed that young graduates who had benefited from training and support programs were easily integrated into their socio-economic fabric and improved their standard of living. In addition, the projects set up by these young entrepreneurs have contributed to the development of their region of Sidi Ifni by creating jobs for other job seekers.
L’impact de la prise en charge des couches sémantiques sur la recherche d'information touristique : Cas des établissements et services touristiques digitalisés au Maroc
Authors:   Université Ibn Zohr, Agadir, Maroc, Tatane Khalid , Amalki Asma , Bouzit Ali
Published: July 2023

Tourism is an economic and a wealth-creating pillar that involves several volatile actors that are rich in dynamic, complex and heterogeneous information (Benckendorff et al., 2019). Therein, the continuous increase in the volume of information available on tourism offerings on the web has made user decision making a crucial task. As a result, the use of personalized and intelligent recommendation systems is essential for the satisfaction of tourism consumers (Grün et al., 2017). The objective of this article is to reveal the impact of the deployment of semantic techniques on the quality and accuracy of search results for tourism information, in the case of tourism in Morocco. This will be done through ontologies, which are a key component in the semantic web (Buhalis, 2020). To this end, we first presented the implementation of the semantic web and the use of ontologies in it. Then, we described the basic background of ontologies. Finally, we discussed the existing ontologies in the tourism domain in Morocco. The findings show that, the assumption of ontological conceptualization during the creation of digital content by tourism establishments, as a context-aware knowledge base, ensures the implementation of a semantic correspondence between users' preferences and the characteristics of tourism offers published, thus improving the quality and accuracy of the recommendations according to the user's context (Abbasi-Moud et al., 2022). Nevertheless, the evolution of tourism ontologies following changes in this sector is of major complexity. For this reason, the invention of an automatic approach, based on artificial intelligence techniques, NLP, Machine Learning or Deep Learning, can contribute to an evolutionary, reliable and easier maintenance of tourism ontologies, in the Moroccan context.
La contribution du système de contrôle de gestion à l’évaluation du capital immatériel des entreprises innovantes : Modèle conceptuel théorique
Authors:   Université Ibn Zohr, Agadir, Maroc, Id Boufakir Abderrahim , Akrich Said
Published: July 2023

With the rise of digitalization and artificial intelligence, intangible capital is recognized, through its components, as a primary source of performance within companies. Alongside the recognition of its importance in determining a company's value, we are witnessing the growing role of management control systems in the context of intangible capital (Novas et al., 2017). As a result, an effective and innovative corporate management control system facilitates the valuation of intangible capital and enhances its contributions (Mouritsen & Roslender, 2009; Tayles et al., 2007). It also effectively supports a company's knowledge capacity (Lee & Widener, 2016) and its quest for competitive advantage (Simons, 1995). The aim of this article is to present a theoretical conceptual model of the contribution of the management control system to the evaluation of intangible capital and its components in innovative companies (Start-ups). We have chosen innovative companies as our field of study because of the immateriality that characterizes this type of company and the close relationship between their values and their ability to assess their intangible capital. Accordingly, we have drawn on resource theory (Barney, 1991), dynamic capability theory (Teece et al., 2008) and the strategic approach to intangible capital management (Arrègle, 2006) as theoretical foundations for the literature. Our study presents a theoretical conceptual model that shows the role of the management control system in the evaluation of intangible capital and its components.
Dilema Moral Teknik “Three-Parents-Baby” Pada Mitochondrial Replacement Therapy
Authors: Febliza Asyti
Published: July 2023

Penyakit mitokondria merupakan salah satu penyakit maternal yang belum dapat disembuhkan. Salah satu cara untuk mencegah diturunkannya penyakit mitokondria yaitu melalui terapi pengganti mitokondria (Mitochondrial Replacement Therapy). Artikel ini bertujuan untuk membahas teknik Mitochondrial Replacement Therapy (MRT) dari aspek moral melalui kajian teoritis dari berbagai referensi yang sesuai. Secara ontologi, penyakit mitokondria merupakan fenomena unobservable yang menyebabkan sekitar 50 bayi dilahirkan menderita penyakit yang parah setiap tahun dan banyak yang meninggal sebelum usia lima tahun di beberapa negara. Secara epistemologi, teknik MRT terjadi secara evolusi yang dikembangkan dari hasil kajian fertilisasi in vitro. Secara aksiologi berkaitan dengan penerapan teknik MRT yang menimbulkan berbagai kontroversial di masyarakat. Dalam menghindari terjadinya dehumanisasi terhadap penerapan teknik MRT, maka teknik MRT terikat oleh nilai (value-bound) yang diatur melalui berbagai kebijakaan pemerintah. Selanjutnya, dipandang dari etika teknik MRT dapat dipandang dari paham deontologi dan paham teleologi. Paham deontologi dalam teknik MRT memberikan rekomendasi cara yang baik dalam melaksanakan MRT melalui aturan kebijakan pemerintah. Sedangkan paham teleologi mengarahkan teknik MRT hanya boleh diberikan kepada pasien dengan tujuan untuk mencegah penularan penyakit mitokondria yang parah.
Merdeka Belajar dan Kampus Merdeka (MBKM) Dalam Pandangan Filsafat Pendidikan Humanisme
Authors: Atika Cahya Fajriyati Nahdiyah  , Sigit Prasetyo  , Nidya Ferry Wulandari  , Ach Chairy
Published: July 2023

Fokus utama artikel ini adalah mengkaji Merdeka Belajar dan Kampus Merdeka (MBKM) dari sudut pandang filosofi pendidikan humanisme. Penelitian ini menggunakan jenis penelitian yang berupa studi kepustakaan (library research). Merdeka Belajar dan Kampus Merdeka (MBKM)merupakan kebijakan Menteri Pendidikan dan Kebudayaan yang bertujuan untuk mendorong mahasiswa memperoleh berbagai ilmu untuk memasuki dunia kerja. Kampus terlepas dari kebijakan belajar mandiri sesuai Permendikbud Nomor 3 Tahun 2020 tentang Standar Nasional Pendidikan Tinggi. Dari perspektif humanistik, merdeka belajar menawarkan mahasiswa kesempatan untuk belajar secara otonomi atau mandiri dan bertanggung jawab atas diri mereka sendiri. Mahasiswa berhak mengikuti ekstrakurikuler di kampus dan berbagai kegiatan di luar universitas, seperti pertukaran mahasiswa, magang/pengalaman kerja, pendampingan mengajar di unit studi, penelitian, proyek kemanusiaan, kewirausahaan, studi/proyek mandiri dan pembangunan desa /Kuliah Kerja Nyata Tematik (KKNT). Keikutsertaan mahasiswa dalam kegiatan ini dapat memberikan pembelajaran (experiential learning) sebagai bekal hidup dan kehidupan di masa depan. Untuk mewujudkan pengalaman belajar tersebut, perguruan tinggi harus menjalin kerjasama dengan dunia usaha/industri dan pemerintah. Kerjasama didasarkan pada peningkatan keterampilan profesional civitas akademika. Kerangka ini mempengaruhi struktur kurikulum dalam mendefinisikan hasil belajar dan menempatkan kuliah di luar perguruan tinggi. Kualitas belajar dan pembelajaran yang bermakna dapat dicapai dengan menerapkan prinsip-prinsip pembelajaran humanistik, yaitu. belajar (learning), belajar mandiri, motivasi diri dan pendidikan afektif. Dengan demikian, MBKM merupakan tujuan pendidikan yang diharapkan dapat mengembangkan hard skill dan soft skill, mempersiapkan peserta didik agar lebih siap dan memenuhi kebutuhan zaman, mempersiapkan lulusan menjadi pemimpin masa depan bangsa yang unggul dan kepribadian dapat dicapai secara optimal di masa yang akan datang.