bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH STRATEGI BISNIS TERHADAP HUBUNGAN MANAJEMEN PERSEDIAAN DAN KINERJA PERUSAHAAN (STUDI PADA PERUSAHAAN PUBLIK DI BEI)
Authors: Rahman Abdul , Haryanto Rudi
Published: May 2024

Abstrak
Penelitian ini bertujuan untuk menguji pengaruh manajemen persediaan terhadap kinerja perusahaan dan menguji pengaruh strategi bersaing terhadap hubungan antara manajemen persediaan dan kinerja.Secara khusus penelitian ini ingin menguji pengaruh strategi bersaing (low cost dan differentiation) terhadap kinerja perusahaan.Penelitian menggunakan pendekatan kuantitatif dengan data sekunder informasi keuangan perusahaan manufaktur yang diperoleh dari database Thompson Reuteurs dan BEI periode 2011.Sedangkan model regresi digunakan untuk menguji hipotesis penelitian.Tahapan penelitian dimulai dari persiapan dan pencarian data keuangan dan referensi terkait permasalahan permasalahan.Selanjutnya melakukan pengumpulan data keuangan dan data lainnya yang mendukung penelitian.Data keuangan yang sesuai dengan variabel penelitian diperoleh dari database BEI berupa Laporan Keuangan Auditan dan Laporan Tahunan Data. Data tersebut akan ditabulasi, diolah, dianalisis dan disimpulkan. Pengolahan data menggunakan software E-Views 7. Hasil penelitian ini menunjukkan: pertama, terdapat hubungan positif dan signifikan antara manajemen persediaan dan kinerja perusahaan; kedua, terbukti strategi berpengaruh memperkuat hubungan antara manajemen persediaan dengan kinerja perusahaan.Dapat disimpulkan bahwa manajemen persediaan mempengaruhi kinerja perusahaan dan terkait juga dengan strategi bersaing perusahaan.

Kata kunci: Strategi, Persediaan, Kinerja

Abstract
The purpose of this study is to test the effect of provision management to the company performance and test the effect competing strategy to the relation of provision and performance management. Especially, this study will test competing strategy (low cost and differentiation) to the company performance. This study use quantitative approach with manufactur company financial information as secondary data obtained from Thompson Reuteurs database and Indonesian Stock Exchange 2011 period. While regression model used to test the research hypothesis. The study started with preparation and financial data and reference finding related to the issue. Then financial and other supporting data collecting. Financial data matched with research variable obtained from Indonesian Stock Exchange in the form of audit financial statement and annual data statement. The data then will be tabulated, processed, analized and concluded. E-Views 7 is used as the processing data software. The result tells about: first, there is a positive and significant relationship between provision management and company performance. Second, it's proved that the strategy has an effect of strengthening the relation of provision management and company performance. It's concluded that provision management affect company performance and related with competing strategy of the company.

Keywords: Strategy, Availability, Performance
Boosting Intercultural Communication Skills: The Role of Authentic Literary Texts in an Intermediate Turkish EFL Classroom
Authors: Torlak Gülten
Published: May 2024

The purpose of this study is to explore cultural barriers and methods of establishing effective communication in English as a Foreign language classrooms. Simply learning grammar rules is insufficient for students to interact effectively; they also need to acquire knowledge about culture, history, and geography through the use of textbooks, documentaries, and movies. With this in mind, the research study aimed to incorporate authentic literary short stories into an intermediate-level class based on the belief that literary texts can help learners develop their intercultural communicative competence. The participants of this study were 25 EFL learners between 18 and 21 years old. The data was collected and analyzed through individual interviews. The findings demonstrate that students can enhance their English language abilities and communication skills through reading authentic books.
Merits and Demerits of English Language Coursebooks Designs: A Scoping Review
Authors: Almalki Mohammed , ALzahrani Saleh , Al-Olaqi Fahd Mohammed Taleb
Published: May 2024

The evaluation process of English coursebooks in Saudi schools began long back when the English curriculum was updated in the 1980s. This paper reviews the works that have surveyed the Saudi English syllabi from the 1990s to the present. It aims to explore the timeline of the most prominent evaluation endeavors. The findings reveal that the common components of evaluations include content, form, learning tasks, and instruction methods. The majority of these attempts were executed using standardized checklists but implemented on a relatively small number of respondents. However, one study was conducted as part of a project launched by the Ministry of Education (MOE) for the development of the English curriculum. The distinctive satisfaction themes of merits among all evaluations were the visuals, syllabi appearance, and overall content. While teaching methods and the difficulty of tasks were highlighted as demerits. From a cultural perspective, syllabi tend to be contextualized in a Western way, based on the local Saudi culture. This paper recommends conducting a more comprehensive evaluation process online to cover more participants, developing a well-tailored checklist that suits the content and culture of Saudi Arabia, and considering the new technological changes in coursebooks.
EFFECT OF TEMPERATURE ON OXYGEN CONSUMPTION AND AMMONIA EXCRETION IN EARTHWORM Libyodrilus violaceus (BEDDARD)
Authors: Melefa Temitope Dadewura , Owa Stephen Olugbemiga
Published: May 2024

Libyodrilus violaceus, an Oligochate of the family Eudrilidae is a species of earthworm found in West Africa. To comprehend how organisms function physiologically, the knowledge of their metabolism is essential. In this present study, the effect of temperature on oxygen consumption and ammonia excretion in this earthworm was studied. Oxygen consumption and ammonia excretion were measured at different temperatures and at different body mass groups. The results obtained show that small sized earthworms produce more ammonia per gram body mass than the large-sized earthworms. This implies that small sized earthworms or juveniles will better convert organic materials into vermicompost than the large sized worms or adult worms. Also, at higher and lower temperatures the earthworms produce more ammonia and consume less oxygen, this could lead to injury and even death of the earthworms. This suggests that temperature could be a limiting factor in vermicoposting and vermiculture. In addition to providing basic data on the ecophysiology of Libyodrilus violaceus, the results from this study give some information that may be useful in vermiculture and vermcomposting. Since small sized worms produce more ammonia than adult or larger sized worm, efforts should be made in rearing more juvenile worms in vermiculture that will be useful in vermicompost since their physiological activities depend on their intake.
Effect of Strains and Clove Supplemented Diet on Adaptability and Meat Quality Traits of Meat Type of Broiler Chickens under Heat Stress Condition
Authors: Badmus Kazeem Ajasa , Abdullahi Abubakar , Tahir Ahmad Abdullahi , Muntaka Adamu , Isa Sheu Saidu , El Hassan Ahmad Kamaluddeen
Published: May 2024

The study was carried out to evaluate the effect of clove administration on the behavioural and meat quality traits of two broiler strains of chickens. A total of ninety-six (96) day old forty-six (46) Arbor Acre and forty-six (46) Cobb 500 of broiler chickens were used for this study. Arbor Acre and Cobb 500 were given feed supplemented with clove (400mg/kg diet) under heat stress of an average temperature of 44 ºC. Their control was fed a diet free from clove. Data were collected on behavioural changes, organoleptic tests, drip loss, cooking loss, pH, and mortality rate. Our results revealed that irrespective of strains, the clove-treated chickens revealed acceptable meat organoleptic evaluation better than the non-clove chickens. There was a significant (p<0.05) effect of strains on cooking loss, where Arbor acre revealed lover cooking loss than Cobb broiler chicken. No significant (P>0.05) effect of treatments on drip loss was obtained. There was a significant (P>0.05) effect of treatments on pH. Normal behavioural dispositions were observed in the clove-treated chickens. Reduced mortality was recorded in the chicken-fed clove. Clove improved the heat tolerant capacity of the Arbor acre and Cobb broiler strains. Therefore, it is concluded that strains and clove affected the meat quality traits of the chicken. Clove on the other hand could be used to improve broiler behavioural disposition, meat quality traits, and adaptability to heat stress conditions of strains of broiler chicken.
Print and Photocopy Service System Design Using Mobile Based Waterfall Method
Authors: Rumondang Tampubolon Margareth , Zainal Rahman Malik  , Reni Reina Nurul Ainun Nissa  , Yezika Oktarmila  , Rikcy Agustius Sinaga  , Putri Mentari Endraswari
Published: May 2024

In today's modern era, archived documents have become crucial as supplements to reports and sources for evaluating work performance. However, many photocopy shops in the Balun Ijuk to Gabek Dua region still lack computerized systems. Consumers must physically visit and queue to receive services from printing and photocopying service providers. This research aims to address the inefficiencies in the printing and photocopying service industry by developing an information system that facilitates location and order processing. The software development methodology employs a waterfall approach, encompassing analysis, design, development, testing, and maintenance. The developed mobile application enables users to locate nearby shops, place orders, and make payments seamlessly. The results demonstrate that the application system enhances the operational efficiency of printing and photocopying services, ultimately saving time and costs for users. This study highlights the significance of utilizing technology to streamline business operations and elevate user experiences in the printing and photocopying service sector.
Analisis Kadar Kalsium (Ca) Pada Lansia Di Panti Perlindungan Dan Rehabilitasi Sosial Lanjut Usia Provinsi Kalimantan Selatan
Authors: Amalia Nurul , Arsyad Muhammad , Khafifah Khafifah
Published: May 2024

The elderly, or senior citizens, are a group of individuals who have reached old age. People in this age group are usually more susceptible to health problems. Calcium is a nutrient that is essential for the body and is the most abundant mineral found in the body, accounting for approximately 1.5-2% of an adult's body weight or about 1kg. Insufficient or excessive calcium intake can lead to abnormal metabolism. Calcium deficiency can result in osteoporosis and hypocalcemia, while excess calcium can cause hypercalcemia. The purpose of this study is to determine the calcium (Ca) levels in the elderly at the "Budi Sejahtera" Social Protection and Rehabilitation Home for the Elderly in South Kalimantan Province. The research design used in this study is a descriptive survey, which is a method used to describe or analyze research findings but not to draw broader conclusions. The calcium levels in the elderly were measured using a cross-sectional design, which observes population or sample data only once at the same time. The sampling was conducted on June 10, 2023. The sample used was blood from the elderly at the "Budi Sejahtera" Social Protection and Rehabilitation Home for the Elderly in South Kalimantan Province, with purposive sampling technique, which is a sampling technique based on specific criteria, resulting in 30 participants out of 69. The calcium levels (Ca) of the 30 respondents were calculated to have a mean of 6.81mg/dl, a maximum of 10.80 mg/dl, and a minimum of 3.30 mg/dl. The results showed that 21 respondents had low calcium levels, 8 respondents had normal levels, and 1 respondent had high calcium levels. Based on the characteristics of the 30 respondents, there were 18 male and female respondents in the younger age group (60-74 years), and 3 respondents in the older age group (75-95 year).
Hubungan Lingkungan, Pendidikan, Dan Ekonomi Masyarakat Terhadap Kejadian TB Paru Di Kedungmundu Kota Semarang
Authors: Salsabilah Kania Shafa , Afriansya Roni
Published: May 2024

Tuberkulosis merupakan penyakit yang disebabkan oleh bakteri Mycobacterium tuberculosis. Kejadian TB Paru berkaitan dengan sanitasi lingkungan, Pendidikan dan ekonomi merupakan faktor predisposisi yang dapat mempengaruhi terjadinya TB Paru. Penelitian ini bertujuan untuk mengetahui hubungan lingkungan, Pendidikan dan ekonomi masyarakat terhadap kejadian TB Paru di Kedungmundu Tahun 2022. Jenis penelitian ini adalah observasinal analitik dengan desain penelitian cross sectional study. Teknik pengambilan sampel menggunakan purposive sampling. Hubungan lingkungan, pengetahuan, dan ekonomi terhadap kejadian TB Paru diuji menggunakan Uji Korelasi Spearman. Rata-rata keadaan lingkungan responden penelitian ini masuk dalam kategori cukup baik. Rata – rata tingkat Pendidikan responden penelitian ini adalah SD dan SMP. Sedangkan untuk ekonomi responden dalam penelitian ini mayoritas masuk kedalam kategori sedang. Ada hubungan yang signifikan antara Lingkungan, Pendidikan, dan Ekonomi masyarakat terhadap kejadian TB Paru dengan nilai Sig (2-tailed) 0.00 < 0.05. Terdapat Hubungan cukup kuat antara Lingkungan, Pendidikan, Ekonomi masyarakat terhadap Kejadian TB Paru di Kedungmundu Tahun 2022.
Compact Binary Formation in Open Star Clusters II: Difficulty of Gaia NS formation in low-mass star clusters
Authors: Tanikawa Ataru , Wang Long , Fujii Michiko S.
Published: May 2024

Gaia mission offers opportunities to search for compact binaries not involved in binary interactions (hereafter inert compact binaries), and results in the discoveries of binaries containing one black hole (BH) or one neutron star (NS), called “Gaia BHs’’ and”Gaia NSs’’, respectively. We have assessed if Gaia BHs and NSs can be formed in open clusters through dynamical interactions. In order to obtain a large number of inert compact binaries similar to Gaia BHs and NSs, we have performed gravitational N-body simulations for a large number of open clusters whose total mass is 1.2×108M⊙. These clusters have various masses, metallicities, densities, and binary fractions. We have found that open clusters form Gaia BHs ( 10−6- 10−5M⊙−1) much more efficiently than Gaia NSs ( ≲10−7M⊙−1) for any cluster parameters. This is quite inconsistent with observational results, because the reported numbers of Gaia BHs and NSs are 3 and 21, respectively. Additionally, we have switched off NS natal kicks for 104 open clusters each weighing 103M⊙ in order to retain a large number of NSs in open clusters. Then, open clusters form inert NS binaries originating from primordial binaries rather than formed through dynamical interactions. This means that Gaia NSs are formed dominantly on isolated fields, not in open clusters, if there is no NS natal kick. We have concluded that Gaia BHs can be dominantly formed in open clusters, however Gaia NSs cannot.
Māori Beekeepers: Reframing New Zealand’s Apiculture Narratives
Authors: Dimitrov Dara
Published: May 2024

New Zealand’s historical apiculture narratives are dominated by the colonial settlers' experiences of beekeeping, which have marginalised Māori experiences. This has perpetuated the notion that, historically, Māori had little to do with beekeeping. However, this article contests this notion and demonstrates that after the introduction of the European, or western honeybee Māori were active participants in the apiculture industry, both as commercial traders and beekeepers. Moreover, this article explores the current contributions that Māori beekeepers make to New Zealand’s apiculture industry but continue to be ignored by the apiculture industry. Despite this, this article shows that Māori beekeepers are making important contributions in the apiculture research space, working with researchers and research institutions to explore climate change impacts, floral honey diversity in the native forests and aspects of honeybee colony health.
Body Shaming Berhubungan Dengan Mekanisme Koping Pada Remaja Di SMK Winongan Pasuruan Kabupaten Pasuruan
Authors: Nurheni Nurheni , Rosdiana ( ID SINTA : 6725591 ) Yanti , Parnawati Tantry Ajeng
Published: May 2024

Dunia pendidikan saat ini menjadi bahan perbincangan tentang maraknya permasalahan sosial, salah satunya adalah kasus body shaming, diperlukan upaya pencegahan melalui mekanisme koping. Penelitian ini bertujuan untuk mengetahui hubungan body shaming dengan mekanisme koping pada remaja di SMKN Winongan Pasuruan Kabupaten Pasuruan Jawa Timur. Desain penelitian mengunakan cross sectional. Desain penelitian menggunakan observasi analitik dengan pendekatan cross sectional, populasi penelitian ini sebanyak 84 siswa dengan jumlah sampel sebanyak 69 siswa. Sampel diambil dengan teknik purposive sampling. Variabel independen adalah body shaming, variabel dependen adalah mekanisme koping. Instrumen yang digunakan berupa lembar kuesioner body shaming among university students dan lembar kuesioner brief-coping orientation to problems experienced. Analisis menggunakan univariat dan bivariat dengan uji spearman. Hasil penelitian ini menunjukkan bahwa sebagian  besar responden memiliki body shaming pada kategori rendah (78,3%); sebagian besar responden memiliki mekanisme koping adaptif (81,2%). Ada hubungan body shaming dengan mekanisme koping pada remaja di SMKN Winongan Pasuruan Kabupaten Pasuruan Jawa Timur (ρ= 0,000). Penelitian selajutnya dapat melakukan penelitian tetang faktor lainya yang dapat mempengaruhi body shaming dan mekanisme koping seperti harapan dan optimisme responden
Kesalahan Penggunaan Teknik Sampling Pada Penelitian Kuantitatif Di Bidang Ilmu Keperawatan
Authors: Choeron Rachmat Chusnul , Nofiana Ika
Published: May 2024

Salah satu indikator kualitas penelitian kuantitatif ialah ketepatan dalam menggunakan teknik sampling, yaitu probability sampling. Namun, masih banyak ditemukan penelitian kuantitatif yang belum mengikuti kaidah randomisasi. Tujuan penelitian ini adalah untuk mengetahui kesalahan penggunaan teknik sampling pada penelitian kuantitatif. Desain penelitian ini menggunakan desain deskriptif kuantitatif. Penelitian ini dilakukan pada hasil-hasil penelitian kuantitatif yang telah dipublikasikan pada jurnal-jurnal keperawatan Sinta 2. Variabel pada penelitian ini adalah penggunaan teknik sampling. Populasi dalam penelitian ini adalah semua hasil penelitian kuantitatif yang dipublikasikan pada jurnal keperawatan sinta 2 yang memenuhi kriteria. Sampel sebanyak  47 hasil penelitian diambil dengan teknik cluster sampling, yaitu memilih secara acak jurnal keperawatan sinta 2 dan mengambil semua artikel hasil penelitian yang ada pada jurnal terpilih hingga jumlah sampel terpenuhi. Data dikumpulkan menggunakan lembar check list. Data yang terkumpul dianalisis menggunakan uji univariate. Hasil penelitian ini didapatkan bahwa hampir seluruh hasil penelitian kuantitatif yang telah dipublikasikan pada jurnal terakreditasi kemenristekdikti memiliki kesalahan dalam penggunaan teknik sampling, yaitu sebanyak 38 jurnal (80,85%). Teknik sampling yang paling banyak digunakan adalah nonprobability sampling, yaitu purposive sampling (47,37%) dan consecutive sampling (42,11%). Pemahaman terhadap teknik sampling perlu ditingkatkan kembali melalui seminar atau pelatihan agar dapat menyempurnakan hasil penelitian kuantitatif yang dilakukan oleh para peneliti.
A Heuristic Model to Find Optimal or Realistic Target Industry Sectors
Authors: Yu Geungu
Published: May 2024

Policymakers or prospective investors recognize a continuing need to find target industry sectors to expand or contract for a sustainably healthy economy or investment portfolios. This paper discusses how to apply an optimal portfolio theory to selecting target industry sectors. With the information technology and the analytical approach in mind, this paper provides an operational and workable framework for selecting target industry sectors for an economy. The application incorporates the capital asset pricing model, ways to find excess return to risk ratios, unsystematic risk measures, etc. First, this paper shows a practical approach to finding the optimal weights for target industry sectors. Second, this paper develops a heuristic framework for analyzing the performance of industry sectors to construct realistic mixes of industry sectors.
Manejo clínico do transtorno de personalidade borderline nas terapias comportamentais: Revisão de literatura
Authors: Sousa Jackson Matos de , Braga Maria Elane Araújo , Costa Maria Suely Alves
Published: May 2024

A literatura sobre o Transtorno de Personalidade Borderline (TPB) evidencia que grandes são os impactos sobre a vida pessoal e social dos indivíduos acometidos, assim como na vida de seus familiares e pessoas próximas. Este trabalho trata-se de uma revisão de literatura do tipo narrativa e tem como objetivo analisar as produções brasileiras sobre o manejo clínico do transtorno de personalidade borderline nas terapias comportamentais. As buscas foram realizadas em algumas bases de dados e foi realizada no intervalo de dez anos e quatro meses (jan/2012 – abr/2022). Encontrou-se a quantidade de 17.076 artigos, sendo que após a utilização dos critérios de inclusão e exclusão permaneceu um total de nove artigos. Sobre as principais características do atendimento à pessoa com TPB, este trabalho apresenta informações sobre a desregulação emocional, a prevalência de gênero, a relação terapêutica, o manejo clínico, as principais teorias e técnicas utilizadas, o diagnóstico, o tratamento e estratégias eficazes nas terapias comportamentais. Em relação às produções brasileiras sobre o TPB, os estudos avaliados confirmaram que há produções, porém são escassez os estudos com esse público, de modo especial sobre a relação terapêutica e intervenções clínicas.
Avaliação da força muscular e funcionalidade de pacientes neurológicos hospitalizados
Authors: Molinari Amanda Orlandelli , Aragão Taiz da Silva , Ferreira Natália Zamberlan , Esteves Larissa Sapucaia Ferreira , Ferreira Aline Duarte
Published: May 2024

Objetivo: Verificar a correlação entre a força muscular respiratória, periférica e funcionalidade de pacientes neurológicos hospitalizados. Métodos: Trata-se de um estudo de caráter transversal, sendo avaliados 22 pacientes neurológicos hospitalizados em um Hospital Regional, onde foi aplicado um questionário para coletar dados pessoais, e foram avaliados força muscular respiratória por meio do Manovacuômetro, força muscular periférica através do Medical Research Council (MRC) e do dinamômetro, e utilizado a escala de Medida de Independência Funcional (MIF) para avaliar independência funcional. A normalidade dos dados foi verificada por meio do teste Shapiro-Wilk, os dados foram expressos em mediana e intervalo interquartílico, frequência e porcentagem. Para as análises de correlação foi utilizado o teste de Tau B de Kendall. O valor de significância adotado foi de p<0,05. Resultados: Houve redução da força muscular respiratória se apresentando abaixo do previsto esperado em todos os pacientes. Ainda, houve correlação positiva entre a dinamometria com a escala MRC e com a PImáx e PEmáx. Também houve correlação positiva entre a escala MIF com os demais instrumentos utilizados. Conclusão: Os instrumentos utilizados apresentaram correlação entre si, e mostraram que o dinamômetro pode indicar força muscular global e servir como um teste simples e eficaz para identificar fraqueza muscular. Ademais, a funcionalidade dos pacientes hospitalizados foi impactada pela força muscular periférica e respiratória. Logo, é imprescindível realizar avaliação dos pacientes em processo de internação a fim do rastreio de declínio funcional, e essa avaliação pode ser feita de maneira segura, rápida e eficaz com instrumentos de baixo custo.
IMPLEMENTATION OF ARMA MODEL FOR BENGAWAN SOLO RIVER WATER LEVEL AT JURUG MONITORING POST
Authors: Siswanti Sri , Vulandari Retno Tri , Setiyowati Setiyowati
Published: May 2024

The amount of annual rainfall in the Bengawan Solo watershed causes high water flow (water discharge) in several rivers. In addition, high flow rates significantly increased the water surface level at some observation sites. The Bengawan Solo River burst its banks in November 2016, causing flooding in several areas in eastern Solo. At that time, the river stage at the Jurug monitoring post passed ten. Therefore, a flood early warning system would be useful for predicting water levels in this context. Every day, one post on the Bengawan Solo River measures the water level. The time series data used in this study is the water level. Autoregressive Moving Average (ARMA) is a predictive method for measuring time set data. The assumption of homoscedasticity or constant error variance is used in this model. However, the study will use the ARMA model if the variance changes randomly. The study used 60 pieces of data from January to February 2018. This study can directly use ARMA because the data results are stationary based on ADF value 0.0036. After the first pause, the ACF and PACF are disconnected based on the correlogram pattern. This shows that the water level of the Bengawan Solo River in that period can appear on the Autoregressive Moving Average with orders p = 1 and q = 1 ARMA(1,1). Thus, the total average residue is 0.0668384, so the short error is 6.68384%.
On the Issue of Integration Education Kyrgyz Language and Kyrgyz Literature
Authors: Muratov A. , Parpieva A.
Published: May 2024

The article describes the most fruitful culturally oriented integration techniques in the practice of teaching Kyrgyz literature and the Kyrgyz language. The importance of subject-integrated learning lies in improving the quality of education and students’ interest in learning. The areas of cultural and creative activity in language universities of Kyrgyzstan are considered. The significance of this study lies in the need for an integrated approach to explaining the practice of teaching and learning the Kyrgyz language. In teaching the Kyrgyz language, as in the modern context of globalization, the technology of integrated teaching of the Kyrgyz language and literature comes to the fore). This technology contributes to the formation of a holistic worldview. The authors of this work found that many topics in Kyrgyz literature correspond to the topics of the Kyrgyz language discipline and can be integrated. The importance of subject-integrated learning lies in improving the quality of education and students' interest in learning. Thanks to modern teaching methods, it can be concluded that teaching the Kyrgyz language in integration with literature will allow students to discover and understand the Kyrgyz culture.
Linguistic activity of Shahtakhtli during the Azerbaijan Democratic Republic
Authors: Saralova F.
Published: May 2024

The end of the 19th and beginning of the 20th centuries are considered a period of revival of national awakening, self-awareness and the emergence of ideas of independence in the aesthetic and public opinion of Azerbaijan. The Azerbaijan Democratic Republic occupies a special place in the history of state independence of our people. In the Republic of Azerbaijan, special importance is attached to the literary language. Azerbaijani linguistics has an ancient history. Studying the history of this linguistics, determining the role and place of outstanding linguists, enlightened intellectuals who played an important role in its development, is of great importance in terms of writing a complete history of the linguistic thought of our scientific linguistics. The Azerbaijani people, with a rich history and enormous scientific heritage, have produced outstanding public figures. At the end of the 19th and beginning of the 20th centuries, one of the greatest linguists of Azerbaijan, who rose to the level of European standards, was the great public figure Muhammad Agha Shakhtakhtli. The prominent prose writer M. Shakhtakhtli tried to implement the ideas of education by publishing journalistic articles in the Russian-language press of the Caucasus, raised with government authorities the importance of educating the people through the media, and preached the need to reform the alphabet. . Studying and working in Europe, in the capital of France, Paris, M. Shakhtakhtli grew up as an outstanding linguist and published numerous articles in the European press about Eastern culture, the development of Azerbaijani education, and the reform of the Arabic alphabet.
Systematic Literature Review : Tantangan Era Globalisasi Bagi Pengembangan Masyarakat Islam
Authors: Adam Hafidz Al Fajar
Published: May 2024

Penelitian ini mendeskripsikan tantangan yang dihadapi oleh masyarakat Islam dalam era globalisasi. Dengan fokus pada aspek ekonomi, budaya, media sosial, dan urbanisasi, penelitian ini menggunakan pendekatan tinjauan literatur berdasarkan metode Systematic Literature Review (SLR). Analisis menyimpulkan bahwa ketidaksetaraan ekonomi, konflik identitas budaya dan agama, dampak teknologi informasi dan komunikasi, serta urbanisasi dan migrasi adalah beberapa tantangan utama yang dihadapi masyarakat Islam. Namun, terdapat juga peluang bagi pengembangan masyarakat Islam, seperti pertumbuhan ekonomi dan akses terhadap pasar global. Implikasi penelitian ini mencakup perlunya kebijakan dan program yang berfokus pada pendidikan, pembangunan ekonomi, dan pengelolaan media sosial. Arah penelitian masa depan termasuk studi tentang ketidaksetaraan ekonomi, pengaruh globalisasi terhadap identitas budaya dan agama, dampak teknologi informasi dan komunikasi, urbanisasi dan migrasi, peluang dalam era globalisasi, pengembangan strategi kolaboratif, dan manajemen tantangan. Diharapkan penelitian ini akan memberikan pemahaman yang lebih baik tentang dinamika masyarakat Islam dalam era globalisasi dan menghasilkan strategi yang lebih efektif untuk mempromosikan kesejahteraan umat Islam secara keseluruhan.
Effects of IMU sensor-to-segment calibration on clinical 3D elbow joint angles estimation
Authors: Bonfiglio Alessandro , Tacconi David , Bongers Raoul M. , Farella Elisabetta
Published: May 2024

Introduction: Inertial Measurement Units (IMU) require a sensor-to-segment calibration procedure in order to compute anatomically accurate joint angles and, thereby, be employed in healthcare and rehabilitation. Research literature proposes several algorithms to address this issue. However, determining an optimal calibration procedure is challenging due to the large number of variables that affect elbow joint angle accuracy, including 3D joint axis, movement performed, complex anatomy, and notable skin artefacts. Therefore, this paper aims to compare three types of calibration techniques against an optical motion capture reference system during several movement tasks to provide recommendations on the most suitable calibration for the elbow joint.

Methods: Thirteen healthy subjects were instrumented with IMU sensors and optical marker clusters. Each participant performed a series of static poses and movements to calibrate the instruments and, subsequently, performed single-plane and multi-joint tasks. The metrics used to evaluate joint angle accuracy are Range of Motion (ROM) error, Root Mean Squared Error (RMSE), and offset. We performed a three-way RM ANOVA to evaluate the effect of joint axis and movement task on three calibration techniques: N-Pose (NP), Functional Calibration (FC) and Manual Alignment (MA).

Results: Despite small effect sizes in ROM Error, NP displayed the least precision among calibrations due to interquartile ranges as large as 24.6°. RMSE showed significant differences among calibrations and a large effect size where MA performed best (RMSE = 6.3°) and was comparable with FC (RMSE = 7.2°). Offset showed a large effect size in the calibration*axes interaction where FC and MA performed similarly.

Conclusion: Therefore, we recommend MA as the preferred calibration method for the elbow joint due to its simplicity and ease of use. Alternatively, FC can be a valid option when the wearer is unable to hold a predetermined posture.
Prognostic significance of compliance with fractional flow reserve guidance on diverse vessel-related clinical outcomes
Authors: Zhang Yang , Yang Bangguo , Ye Yicong , Zhao Xiliang , Ding Yaodong , Ye Yi , Zhang Liang , Tan Dawei , Zhang Gong , Duan Xiaoyu , Li Quan , Zeng Yong
Published: May 2024

Background

In patients underwent fractional flow reserve (FFR) assessment, a noteworthy proportion of adverse events occur in vessels in which FFR has not been measured. However, the effect of these non-target vessel-related events on the evaluation of FFR-related benefits remains unknown.

Methods and results

In this retrospective study, vessels subjected to FFR measurement were grouped as FFR-based approach and non-compliance with FFR based on whether they received FFR-based treatment. Using inverse probability of treatment weighting (IPTW) to account for potential confounding, we investigated the association between compliance with FFR and 5-year target vessel failure (TVF) non-target vessel failure (NTVF) and vessel-oriented composite endpoints (VOCEs). Of the 1,119 vessels, 201 did not receive FFR-based treatment. After IPTW adjustment, a signiﬁcantly lower hazard of TVF was observed in the FFR-based approach group (HR: 0.56; 95% CI: 0.34–0.92). While, the intergroup difference in hazard of NTVF (HR: 1.02; 95% CI: 0.45–2.31) and VOCEs (HR: 0.69; 95% CI: 0.45–1.05) were nonsignificant.

Conclusions

In patients with CAD subjected to FFR, the FFR-based treatment yields a sustained clinical benefit in terms of the risks of target vessel-related events. The dilution of non-target vessel-related events renders the difference favoring the FFR-based approach nonsignificant.
Core-shell 3D printed biodegradable calcium phosphate cement—Alginate scaffolds for possible bone regeneration applications
Authors: Schweiker Clara , Zankovic Sergej , Baghnavi Anna , Velten Dirk , Schmal Hagen , Thomann Ralf , Seidenstuecker Michael
Published: May 2024

The core/shell 3D printing process using CPC and alginate is intended to create biodegradable scaffolds that have a similar stability to bone tissue and also offer sufficient and continuous antibiotic release. In this way, a patient-specific and patient-friendly process will be established, which should optimally support the human organism in its regeneration. To generate the best possible strength values, the printed scaffolds underwent various post-treatments and were then tested in a material test. The test methods included self-setting, storage in a drying cabinet with a water-saturated atmosphere at 37°C, followed by incubation in PBS, freeze-drying, and coating the samples with alginate. Additionally, a degradation test at pH 7.4 and pH 5 was carried out to test stability under in vitro conditions. It was shown that the untreated and freeze-dried samples failed at a maximum load of 30–700 N, while the remaining scaffolds could withstand a load of at least 2,000 N. At this failure load, most of the test series showed an average deformation of 43.95%. All samples, therefore, remained below the strength of cancellous bone. However, based on a 20% load after surgery, the coated scaffolds represented the best possible alternative, with a Young’s modulus of around 1.71 MPa. We were able to demonstrate that self-setting occurs in core-shell printed CPC/alginate scaffolds after only 1 day, and that mass production is possible. By coating with alginate, the compressive strength could be increased without the need for additional post-treatment. The mechanical strength was sufficient to be available as a scaffold for bone regeneration and additionally as a drug delivery device for future applications and experiments.
Sex and age significantly modulate cardiovascular disease presentation in type 2 diabetes: a large population-based cohort study
Authors: Jiménez Amanda , Vlacho Bogdan , Mata-Cases Manel , Real Jordi , Mauricio Dídac , Franch-Nadal Josep , Ortega Emilio
Published: May 2024

Aims

We aimed to describe and compare the incidence of the first cardiovascular event and its major subtypes, coronary heart disease (CHD), cerebrovascular disease, heart failure (HF), or peripheral artery disease (PAD), according to age and sex in a population-based cohort of individuals with type 2 diabetes (T2D) from a Mediterranean region.

Material and methods

We used linked primary care electronic medical reports, pharmacy-invoicing data, and hospital admission disease registry records from the SIDIAP database, which contains linked data for 74% of the Catalonian population. We selected individuals with T2D aged 30 to 89 years free of cardiovascular disease (CVD). The primary outcome was the first presentation of CVD.

Results

The study cohort included 247,751 individuals (48.6% women, 66.8 ± 11.9 years). During a 6.99-year follow-up, the cumulative incidence of the first cardiovascular event was 23.4%. Men were at higher risk for CVD (hazard ratio [HR]: 1.47 95%CI: 1.45-1.50), CHD (HR: 1.52 95%CI: 1.47-1.57), cerebrovascular disease (HR:1.07 95%CI: 1.03-1.10) and PAD (HR: 2.30 95%CI: 2.21-2.39) than women but at a lower risk for HF (HR:0.70 95%CI: 0.68-0.73). CHD and PAD were the most frequent CVD presentations among men (28.1% and 27.5%) and HF (40.1%) in women. CHD predominated among young participants of both sexes, while HF predominated among women older than 65 and men older than 75.

Conclusions

In individuals with T2D, the overall risk and the type of first CVD manifestation largely varied by sex and age. This epidemiological evidence should be considered in clinical practice.
Lung ILC2s are activated in BALB/c mice born to immunized mothers despite complete protection against respiratory syncytial virus
Authors: Kosanovich Jessica L. , Eichinger Katherine M. , Lipp Madeline A. , Gidwani Sonal V. , Brahmbhatt Devarshi , Yondola Mark A. , Chi David H. , Perkins Timothy N. , Empey Kerry M.
Published: May 2024

Activated lung ILC2s produce large quantities of IL-5 and IL-13 that contribute to eosinophilic inflammation and mucus production following respiratory syncytial virus infection (RSV). The current understanding of ILC2 activation during RSV infection, is that ILC2s are activated by alarmins, including IL-33, released from airway epithelial cells in response to viral-mediated damage. Thus, high levels of RSV neutralizing maternal antibody generated from maternal immunization would be expected to reduce IL-33 production and mitigate ILC2 activation. Here we report that lung ILC2s from mice born to RSV-immunized dams become activated despite undetectable RSV replication. We also report, for the first time, expression of activating and inhibitory Fcgamma receptors on ILC2s that are differentially expressed in offspring born to immunized versus unimmunized dams. Alternatively, ex vivo IL-33-mediated activation of ILC2s was mitigated following the addition of antibody: antigen immune complexes. Further studies are needed to confirm the role of Fcgamma receptor ligation by immune complexes as an alternative mechanism of ILC2 regulation in RSV-associated eosinophilic lung inflammation.
IgG sialylation occurs in B cells pre antibody secretion
Authors: Werner Anja , Hanić Maja , Zaitseva Olga O. , Lauc Gordan , Lux Anja , Nitschke Lars , Nimmerjahn Falk
Published: May 2024

Sialic acids as terminal sugar residues on cell surface or secreted proteins have many functional roles. In particular, the presence or absence of α2,6-linked sialic acid residues at the immunoglobulin G (IgG) Fc fragment can switch IgG effector functions from pro- to anti-inflammatory activity. IgG glycosylation is considered to take place inside the plasma blast/plasma cell while the molecule travels through the endoplasmic reticulum and Golgi apparatus before being secreted. However, more recent studies have suggested that IgG sialylation may occur predominantly post-antibody secretion. To what extent this extracellular IgG sialylation process contributes to overall IgG sialylation remains unclear, however. By generating bone marrow chimeric mice with a B cell-specific deletion of ST6Gal1, the key enzyme required for IgG sialylation, we now show that sialylation of the IgG Fc fragment exclusively occurs within B cells pre-IgG secretion. We further demonstrate that B cells expressing ST6Gal1 have a developmental advantage over B cells lacking ST6Gal1 expression and thus dominate the plasma cell pool and the resulting serum IgG population in mouse models in which both ST6Gal1-sufficient and -deficient B cells are present.
Updating and validating seagrass ecosystem knowledge in the gulf of California: a comprehensive review
Authors: Ramírez-Zúñiga Magali Alejandra , Pérez-Estrada Claudia Jeannette , López-Calderón Jorge Manuel , Cannon Abigail Libbin , Vanderplank Sula , Favoretto Fabio
Published: May 2024

Seagrasses are globally acknowledged as crucial habitats as they provide a variety of ecosystem services. Mexico’s legislation protects most of these marine plants; however, the protection often fails in application. The Gulf of California, despite being a biodiversity hotspot, has scant data on seagrasses. Here, human activity and climate change increasingly threaten these coastal ecosystems, with conservation and research efforts lacking coordination at a regional level. Our manuscript aimed to review and standardize existing data on Gulf of California seagrass species, ensuring open access for data updates; pinpointing conservation deficiencies; and guiding future research. We have added new records to the official public data, but we were able to recapture only 25% of the seagrass locations meaning a potential reduction in their historical distribution of 45.8%. Even though Mexico’s legislation protects some species of seagrasses, it protection often fails in the application. We identified that only 6.1% of the seagrass locations are within protected areas that recognize their presence in their management plans (e.g., the Balandra Flora and Fauna Protected Area and the Upper Gulf of California and Colorado River Delta Biosphere Reserve). At least 55.9% of seagrass records are associated with potentially damaging activities like pollution, coastal modification or biological resources use, while 23% are exposed to higher frequency of marine heatwaves. Given the importance of seagrass meadows under Mexican law and their internationally recognized ecological value, sharing current information and guiding research is essential. Our study seeks to galvanize renewed research initiatives and raise more awareness on the conservation of the Gulf of California’s seagrasses.
Integration of BMP-2/PLGA microspheres with the 3D printed PLGA/CaSO4 scaffold enhances bone regeneration
Authors: Zhao Li , Zhao Xiaoliang , Deng Fengpiao , Ye Xiangling , Shen Zhen , Xia Yuanjun , Zhang Ying
Published: May 2024

Treatment of large and complex irregular bone defects is a major clinical challenge in orthopedic surgery. The current treatment includes bone transportation using the Ilizarov technique and bone cement repair using the Masquelet technique, but they require long-term manual intervention or secondary operation. To improve this situation, we compared the different implanting materials in the literature published in the past 10 years, finding that glycolic acid copolymer (PLGA) and Calcium sulfate (CaSO4) are appropriated to be used as synthetic bone materials due to their advantages of easy-availability, nontoxicity, osteogenic properties and rapid degradation. Meanwhile, the development of 3D printing technique and devices makes it relatively easier to synthetize customized bio-mimetic porous scaffolds, thus facilitating the release of modified protein. In this study, we compounded BMP-2/PLGA microspheres with polylactic glycolic acid copolymer/CaSO4 (PC) 3D printed scaffold to improve the osteogenic properties of the scaffold. The result of our in vitro experiment demonstrated that the prepared PCB scaffold not only had satisfactory bio-compatibility, but also promoted osteogenic differentiation. This 3D printed scaffold is capable to accelerate the repair of complex bone defects by promoting new bone formation, suggesting that it may prove to be a potential bone tissue engineering substitute.
Nutrient optimization in bioleaching: are we overdosing?
Authors: Falagán Carmen , Sbaffi Tomasa , Williams Gwion B. , Bargiela Rafael , Dew David W. , Hudson-Edwards Karen A.
Published: May 2024

The general trend in biomining (i.e., bioleaching and biooxidation) is the use of media with high concentrations of the nutrients (nitrogen as ammonium, phosphorous as phosphate, and K), which are considered to be essential for microbial growth. The depletion of any of the nutrients would affect negatively the bioleaching (and biooxidation) capacity of the microorganisms, so the formulation of the different media ensures that there is a surplus of nutrients. However, some of these nutrients (e.g., phosphate, K) may be already present in the ore and are made available to the microorganisms when the ore is exposed to the low-pH media used during bioleaching. The effect of phosphate addition (109 mg/L) and depletion on the bioleaching of low-grade sulfidic ore alongside the determination of ammonium (i.e., 25 mg/L, 50 mg/L, 109 mg/L, 409 mg/L, and 874 g/L) requirements were studied. The results of the experiments presented showed that the addition of phosphate did not have any effect on the bioleaching of the low-grade sulfidic ore while the addition of ammonium was necessary to obtain higher redox potentials (>650 mV vs. Ag/AgCl) and higher metal (Co, Cu, Ni, and Zn) dissolutions. Temperature was the factor that shaped the microbial communities, at 30°C, the microbial community at the end of all the experiments was dominated by Acidithiobacillus sp. as well as at 42°C, except when nutrients were not added and Sulfobacillus sp. was the dominant microorganism. At 55°C, DNA recovery was unsuccessful, and at 60°C, the microbial communities were dominated by Sulfolobus sp. In conclusion, the amount of nutrients in bioleaching could be reduced significantly to achieve the redox potentials and metal dissolution desired in bioleaching without affecting the microbial communities and bioleaching efficiencies.
Where the cerebral infarction meets child, be vigilant about patent foramen ovale: a case report
Authors: Zhang Zai-qiang , Ding Jia-wang
Published: May 2024

Background

While cerebral infarction in children is rare, its prognosis is poor, and this condition can seriously burden society and families. A correlation between patent foramen ovale (PFO) and ischemic stroke has not been found in pediatric patients.

Case presentation

We report a 7-year-old boy who suffered from multiple cerebral infarctions. Subsequently, the patient was diagnosed with an abnormal shunt of PFO. He underwent PFO closure and was followed up for 1 year. The patient did not experience any further cerebral infarction.

Conclusions

With this case report, we want to illustrate that although the incidence rate of ischemic cerebral infarction in adolescents is very low, we should not neglect the role of PFO. Therefore, after exclusion other causes of cerebral infarction, PFO should be considered in adolescent and adult stroke patients with adult closure criteria in the same way.