bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Edukasi Kesehatan terhadap Tingkat Pengetahuan Keluarga tentang Pengawas Minum Obat (PMO) pada Pasien Tuberkulosis Paru di Kota Jambi Tahun 2022: Studi Kasus
Authors: Erwinsyah Erwinsyah , Yusmahendra Devi , Jannah Miftahul , Martawinarti Rts Netisa
Published: June 2023

Pulmonary tuberculosis (pulmonary TB) is a contagious infectious disease that was still a public health problem in the world, including Indonesia. The World Health Organization (WHO) classifies TB as an endemic disease that is difficult to eradicate. The study aims mmmo Provide information and add scientific discourse for nurses in the Effect of Health Education on Knowledge Levels of Family Members about PMO in Pulmonary Tuberculosis Patients. This type of research was descriptive with a case study method in pulmonary tuberculosis patients by providing health education about the role of drug-taking supervisors for pulmonary tuberculosis patients. The results of the implementamtion of this health education were by giving a questionnaire directly to 1 respondent, namely by carrying out the stages of health education in Pulmonary Tuberculosis patients to increase the role. After implementing health education for the families of patients with pulmonary TB for 3 days, the families of pulmonary tuberculosis patients can apply participation in PMO in their daily lives. It is hoped that the results of this study can be used as information material in motivating health workers of ​​the public health centers to know of Jambi about the importance of the role of PMO at pulmonary TB patients.
Abstrak
Penyakit tuberkulosis paru adalah penyakit infeksi menular yang masih tetap merupakan masalah kesehatan masyarakat di dunia termasuk Indonesia. Ormganisasi kesehatan dunia WHO menggolongkan TB sebagai penyakit endemik yang sulit dihilangkan. Penelitian ini bertujuan untuk memberikan informasi dan menambah wacana keilmuan bagi perawat terhadap pengaruh edukasi kesehatan terhadap tingkat pengetahuan anggota keluarga tentang PMO pada pasien Tuberkulosis Paru. Jenis penelitian ini adalah deskriptif dengan metode studi kasus pada pasien Tuberkulosis paru dengan memberikan edukasi kesehetan tentang peran serta pengawas mknum obat bagi penderita Tuberkulosis paru, alat pengukuran penelitian ini adalah kuesioner pengetahuan. Penerapan edukasi kesehatan ini dengan cara memberikan kuesioner secara langsung pada 1 reponden, yaitu dengan melakukan tahap-tahap emdukasi kesehatan pada pasien Tuberkulosis Paru untuk meningkatkan peran pada PMO. Setelah dilakukan penerapan edukasi kesehatan pada keluarga pasien dengan TB Paru selama 3 hari, keluarga pasien Tuberkulosis Paru dapat menerapkan peran serta dalam PMO dalam kehidupan sehari-hari. mDiharapkan hasil penelitian ini dapat dijadikan sebagai bahan informasi dalam memotivasi petugas kesehatan di wilayah kerja puskesmas kenali besar kota jambi tentang pentingnya peran PMO pada pasien TB paru.m
Kata Kunci: Edukasi Kesehatan, Tuberkulosis paru, Pengawas Minum Obat
Island of Totalitarinism: Macbeth by Orson Welles
Authors:   Russian State Institute of Performing Arts, Kleiman Yulia A.
Published: June 2023

By the time of the eventual success of the premiere of Macbeth (1936) directed by Orson Welles as part of the Harlem Negro project by FTP, the African American theater already had its own small but remarkable history. However, this production received a tremendous response and is still the subject of controversy among scholars: evidence of this resonance is the appearance of the feature film Voodoo Macbeth (2021). All roles were performed by black actors, and the action was transferred to Haiti during the reign of Henry Christophe. Critics were disturbed by the disrespectful attitude to the Shakespearean text, modern researchers — by the exoticization of the African American cultural code. The reason for the discussion was (and still is) the director's radical interpretation, which shifted the semantic accents from Macbeth and Lady Macbeth to the witches. By increasing their role quantitatively and qualitatively, Orson Welles, a contemporary of the growing totalitarian regimes, created a piece about the all-pervading evil leveling the human personality. Having changed the chronotope of Shakespeare's tragedy and rethinking the principle of working with Shakespeare's heritage, Welles, for the first time in the history of American theatre, invited black actors to perform universal characters, to work with classical dramaturgy. Article is based on vast amount of archival materials, critical reviews and researches on Orson Welles and the Federal Theatre Project. Article examines the steps of the formation of the director's and set designer’s concepts, a reconstruction of the production is executed among other purposes.
On the Wreckage of the Bastille of Rhymes
Authors:   Lomonosov Moscow State University, Belavina Ekaterina M.
Published: June 2023

Two texts by A. Rimbaud, published in 1886, but written earlier, and not poems by G. Kahn, J. Laforgue or J. Moréas, are considered the first vers libre in French. The paper shows two approaches to the analysis of free verse rhythm: the rules for reading and counting silent [Ə]; free verse is considered as a derivative of verse or prose, respectively (K. Scott and M. Murat), which proves the fundamental ambiguity of this poetic form and the importance of the reader’s perception in the process of reading as co-creation. The arguments of opponents and supporters of free verse, the so-called “free verse controversy” (“querelle du vers libre”) prove that in the imagination of writers there exists the connection between the poetic system and the social order. The paper considers the opposition proposed by the French researcher M. Murat — that of the national French vers libre and the international free verse that goes back to the American, that is to say Whitman’s model of Whitman through Valerie Larbeau’s poetry. The creative act of Larbeau, who created a heteronym — the English-language poet Barnabooth, raises the question of erasing national prosody and switching the linguistic code.
“Interpreter of Life” and “Maker of Universes”: Bernard Shaw and Albert Einstein
Authors:   Lomonosov Moscow State University, Skalnaya Yulia A. ,   Military University of the Ministry of Defense of the Russian Federation
Published: June 2023

The article focuses on the two great figures of the XX century, Bernard Shaw and Albert Einstein. Their occupations belonged to quite distant realms of science and fiction, and the only event that united the two in public consciousness was Shaw’s speech in honor of Einstein at the OTR fundraising dinner at the Savoy Hotel on 28th October 1930 where he bestowed the honorary title of “Maker of the Universe” upon the scientist. However, these two great men had much more in common than it is generally accepted. The paper presents some little-known details of Shaw — Einstein relationship, establishes a correlation between their views on a number of socio-political, scientific, philosophic, ethical and aesthetical issues including common grounds and principal differences in their attitude towards the USA and the American social structure. Apart from the few existing articles in the foreign academic journals, this research relies on the official European and American press records of Shaw’s and Einstein’s speeches, their private correspondence, diary entries, memoirs and (auto)biographies created by their close friends, colleagues and contemporaries (such as Beatrice Webb, Leopold Infeld, Ronald Clark), as well as Einstein’s essays and Shaw’s dramas. Another significant figure in the paper is the American writer and scientist Archibald Henderson who, according to professor W.L. Phelps, was “perhaps the only living man who can talk on their own level with the two greatest intellects of today, George Bernard Shaw and Albert Einstein.” The vast majority of documents, radio and video addresses cited in this article have not been translated into Russian; the paper is a pioneering study in Russia, where this topic remains unknown and haven’t so far attracted attention of the Russian academia.
Verbal Art & TD: Tatiana Venediktova Anniversary
Authors:   Lomonosov Moscow State University, Astvatsaturov Andrey A. , Balditsyn Pavel V. ,   Lomonosov Moscow State University, Zenkin Sergei N. ,   Russian State University of Humanities,   National Research University Higher School of Economics, Zubov Artem A. ,   Lomonosov Moscow State University, Idlis Julia B. ,   Tallinn University, Kruzhkov Grigorii M. ,   Russian State University of Humanities, Makeev Mikhail S. ,   Lomonosov Moscow State University, Polosina Natalia K. ,   Lomonosov Moscow State University, Shvets Anna V. ,   Lomonosov Moscow State University
Published: June 2023

The anniversary collection of essays compiled and edited by Nataliia Polosina, Anna Shvets and Artem Zubov pays tribute to Tatiana Venediktova — Doctor of Philology, professor of American studies, founder and chair of the Department of Discourse and Communication studies at the Philological Faculty of Lomonosov Moscow University, member of the LoA editorial board. Her colleagues, friends and students contributed to the collection. Pavel Balditsyn, Julia Idlis, Mikhail Makeev, Grigoriy Kruzhkov recall the experience of cooperating with Tatiana Venediktova and working on major joint projects like the History of Literature of the United States (1997–2013) and editions of American poets in the academic book series “Literturnye Pamiatniki”. They focus on her work as a researcher, teacher, translator, publisher, academic administrator. The essays by Andrey Astvatsaturov and Sergei Zenkin commemorate the 20th anniversary of her seminal book Conversation in American: Discourse of Bargaining in the American Literary Tradition (2003). They reflect upon the impact the book had in the Russian academia back in the 2000s and its relevance for the humanities scholarship in the 2020s. The anniversary collection is a symbol of gratitude, love and respect towards Tatiana Venediktova, a recognition of her valuable contribution to the American studies and humanities in general in Russia and beyond.
Greetings from Havana: MAPRYAL Forum in Cuba
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kofman Andrey F.
Published: June 2023

In 2022 (December 12–14) Havana hosted the International educational and cultural forum “Russian Literature in Latin America: Ideas and Values for the Future of the World”. The forum was organized by the MAPRYAL (International Association of Teachers of Russian Language and Literature) in cooperation with the University of Havana. The aim of the forum is to strengthen interaction among members of academic and educational communities of Latin American countries studying Russia and its cultural heritage. The forum was attended by over 200 delegates — teachers, scholars, writers, translators, literary critics, representing Cuba and other Spanish-speaking countries (Argentina, Colombia, Uruguay, etc.), as well as Russian educational and scholarly institutions. The Russian delegation included representatives of the Institute of Russian Literature (Pushkinskij Dom) and A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, St. Petersburg State University, Moscow State Institute of International Relations (MGIMO), Pushkin State Institute of the Russian Language, Maxim Gorky Institute of Literature and Creative Writing, Ural Federal and Southern Federal Universities, reputed writers, critics, translators and scholars, among them Evgeny Vodolazkin, Alexey Varlamov, Pavel Basinksy, the representatives of A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, — Vadim Polonsky and Andrey Kofman. Cuban and Latin American Russian studies were also widely represented: at the forum sessions, speeches were made by teachers of Russian, translators, writers, scholars, literary critics, publishers — Omar Lobos, Alejandro Ariel Gonzalez, Ruben Dario Flores, Raul Rodriguez de Silva, Irina Luna and many other reputed professionals whose activities are related to the Russian language and literature.
Walt Whitman: Gallerist in New York
Authors:   Lomonosov Moscow State University, Venediktova Tatiana D.
Published: June 2023

In mid-XIX century mechanical reproduction of images through lithography and photography becomes increasingly available — it allows for visual entrepreneurship on a growing scale. In literary artists this trend causes skepticism but in some (like O.W. Holmes) it also inspires creative interest. That the interaction between commercial and technological practices could be productive of aesthetic insight is proved by Walt Whitman’s poetic experiment. Whitman was fascinated by the art of photography – for a daguerreotype he would sit often, willingly and self-consciously, thus turning a portrait into an auto-portrait. Most of the editions of Leaves of Grass contain the author’s images, while Whitman’s form, the very principles his world-building imagination can be best understood through “photographic logic”. Two versions of the poem My Picture Gallery (the one dating back to mid-1850s and the one published in 1881) are being analyzed as instances of Whitman’s lifelong reflection on how the image, the world and the human subject interact. This relationship is full of submerged drama: technical reproducibility makes the image strikingly lifelike but also contributes to the “derealization” or “virtualization” of the world — tends to empower the subject but also to disable one through “the terrible doubt of appearances”. The visual analogue of the “catalogue” technique, representative of Whitman’s early manner, may be a sequence of snapshots and / or that of imperative pointing gestures: see, watch, imagine! Manicules are often used in Whitman’s early manuscripts: this typographic sign (described as “hand” or “printer’s fist”) is pervasive in newspaper advertising of the poet’s time and of particular interest to him — most probably, because giving a sense of forceful, embodied presence, direct contact with the world and the reader alike. In later editions the gesture gets a different representation — a butterfly rests, distractively, upon the index finger using it as a momentary landing grund. This image — Whitman’s newly chosen visual brand – is expressive of the contemplative attitude, indeterminacy and suggestiveness increasingly of import in his poetics.
Filibusters and Mikhail Bulgakov’s Handwritten Legacy
Authors:   V.V. Vinogradov Russian Language Institute of the Russian Academy of Sciences, Druzhinin Petr A.
Published: June 2023

The article describes the recently discovered Mikhail Bulgakov’s inscription and debates with the researchers who tend to interpret the inscription as the writer’s genuine manuscript marked with the syntactic and lexical features characteristic of his style. The alleged autograph presents an inscription addressed to the writer Vikenty Veresaev on the Mikhail Meisel’s book “A Brief Outline of Modern Russian Literature” (1931). Offering his own point of view on the inscription, the author compares the text of the manuscript with the true facts of Vladimir Meisel’s biography, who is presented in this inscription in the image of a filibuster. The article analyzes the legitimacy of the use of maritime vocabulary, gives examples of its use in the novel The Master and Margarita, thus proving that there is no reason to associate Mikhail Maisel with the image of the filibuster. The study of Mikhail Bulgakov’s epistolary suggests that we are dealing with the processing of Bulgakov’s letter, in which the image of Vsevolod Vishnevsky is drawn using maritime vocabulary. The latter seems logical being confirmed by the facts of Vishnevsky’s biography. Since the vocabulary refers to a completely different person and has Bulgakov’s original manuscript as its source, it can be concluded that the newly found autograph is a literary hoax created using the original texts of Mikhail Bulgakov. This particular example demonstrates the effectiveness of philological methods for recognizing falsified manuscripts of the classics of Russian literature — a problem of textual criticism which remains salient.
Reception of Proust in Russia in the 1920s
Authors:   Ivanovo State University, Taganov Alexander N.
Published: June 2023

The article traces the history of the reception of Marcel Proust’s works in Russia, which began in the 1920s. The problem of studying the perception of Proust’s literary heritage, which has not yet been fully investigated, is of particular importance, since it allows us to touch upon a number of important issues of theoretical and historical-literary plans. Proust as an object of research is chosen here not by chance. In the world literary space there are special constant values, which, if to compare with various artistic phenomena, allows us to understand their artistic value, to follow the change of axiological parameters that determine the state of a particular stage of the literary process and to identify the main directions of development in it. Reception in the Russian culture works by Proust, which, of course, is one of such values, deserves special attention and study, since it reveals important moments not only in the creative activity of the French writer, but also in the development of Russian fiction and literary criticism. Based on the analysis of numerous documentary evidences contained in periodicals (“The Modern West,” “The Press and the Revolution,” “On a literary post,” etc.), theoretical and literary-critical works of authoritative literary critics (N.Y. Berkovsky, V.V. Weidle, B.A. Griftsov, A.K. Voronsky, etc.), in the statements of famous writers (O.E. Mandelstam, V.V. Mayakovsky, Y.K. Olesha, I. Ilf and E. Petrov), research reveals how the attitude to the works by Proust in the specified period of Soviet literature development, which is characterized by the coexistence and confrontation of various schools and trends (“Forge,” “Pass,” RAPP, LEF, etc.), helps to clarify their aesthetic orientation.
From the Letters of Mikhail Muravyev of 1776: A.A. Barsov, V.I. Maykov, M.M. Kheraskov and “Free Russian Assembly”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Ivinskiy Alexander D.
Published: June 2023

The article is devoted to one of the most important events in the literary biography of Mikhail Muravyev, that has not yet attracted the attention of researchers, i. e. his joining the “Free Russian Assembly” in 1776. For the analysis of this problem the author of the article uses unpublished letters of the writer, which are stored in the Department of Written Sources of the State Historical Museum (Moscow). We publish and comment in the appendix to the article eight Muravyev’s letters to his father and sister. These materials allow us to take a fresh look at the history of Muravyev’s relationship with A.A. Barsov, Kh.A. Chebotarev, V.I. Maikov, M.M. Kheraskov, I.I. Melessino. In addition, these data also allow us to present a reconstruction of Muravyev's reception of literary position of A.P. Sumarokov. In just a few days at the end of 1776, Muravyev, who later would be famous for the lack of a public activity, became a part of a large and complex intellectual and social environment that included Moscow poets, scientists, and high-ranking Freemasons. Our hypothesis is that these acquaintances determined the whole subsequent life of the writer, since, perhaps, it was the “Muscovites” who nominated Muravyov to the role of educator of the Grand Dukes Alexander and Constantine and thereby helped him take a place at court, which ultimately led to his sharp rise in the beginning of the Alexander era, cut short by sudden death in 1807.
V.M. Golitsyn and A.M. Gorky: The History of Board Games
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kudrina Elena V.
Published: June 2023

The article deals with newly founded letter from Vladimir Mikhailovich Golitsyn to Maxim Gorky from the section of children’s letters of A.M. Gorky Archive (IWL RAS). The letter was written on June 8, 1935 and was dedicated to historical games for Soviet children. It contains an approximate plan for a series of board games that were developed by V.M. Golitsyn. Historical games were not just entertainment and a pleasant pastime for Golitsyn, but an important element of teaching and raising children. Their goal was to arouse the interest of players in history, geography, literature, immersion in an interesting and exciting world of knowledge and adventure, the development of attention and memory. In the letter, Golitsyn expresses doubts and asks Gorky for advice. This letter was unknown to researchers of the artist and inventor. The article clarifies the history of Golitsyn’s strategic games “Pirates,” “Capture of Colonies,” “Rescue of Chelyuskinites,” “Runaways,” etc. The board game “Pirates” was approved by Gorky, it was played by A.A. Zhdanov, V.M. Molotov and L.M. Kaganovich, but because of bureaucratic and ideological obstacles, it was not published in a separate edition during the author’s lifetime, and most Soviet children did not know about this educational game. V.M. Golitsyn’s letter to Gorky and its appendix are published for the first time.
Os Limites da Lei de Fomento em Porto Alegre
Authors: Bicca Rolim Michele , Dias Massa Clóvis
Published: June 2023

Este artigo discute as características e a finalidade do Programa Municipal de Fomento ao Trabalho continuado em Artes Cênicas para a cidade de Porto Alegre/RS, lei Nº 10.742, de 1º de setembro de 2009. A partir de exemplos concretos de grupos e companhias beneficiadas com o fomento, e tendo como referência a experiência pioneira do financiamento público direto à cultura do Programa Municipal de Fomento ao Teatro para a cidade de São Paulo, o estudo propõe uma discussão sobre os mecanismos de financiamento do setor teatral e as condições de sustentabilidade financeira dos grupos de teatro da cidade de Porto Alegre, bem como tensiona o debate sobre as políticas públicas culturais necessárias para garantir o trabalho continuado dos grupos teatrais. Para isso, aborda os limites e restrições da lei em efetivar a viabilidade econômica do setor das artes cênicas e o papel do Estado na sua promoção.
Do litígio à pacificação: uma análise do processo de normatização da Política Judiciária Nacional de tratamento adequado de conflitos de interesses
Authors: Mazurok Schactae Fabiane , Damião Serafim Monia Regina
Published: June 2023

O presente artigo caracteriza-se em uma análise de conjuntura da Resolução nº 125 publicada no ano de 2010 pelo Conselho Nacional de Justiça (CNJ), que instituiu a Política Judiciária Nacional de tratamento adequado de conflitos de interesses no âmbito do Poder Judiciário.Esse acontecimento institucionalizou os métodos consensuais, em especial a conciliação e a mediação, como um serviço a ser prestado pelo Poder Judiciário, sendo um marco normativo para o estabelecimento de um novo paradigma na resolução de conflitos de interesses. O objetivo é verificar, por meio de uma análise do contexto social e político, os motivos que contribuíram para que o CNJ instituísse a referida política judiciária, que apresenta grande relevância na conjuntura processual brasileira e teve reflexo direto na lei que instituiu o novo Código de Processo Civil brasileiro. Para tanto, realizou-se uma investigação com a metodologia qualitativa, utilizando-se do método dedutivo, realizando-se uma pesquisa descritiva e bibliográfica. Como resultado, observou-se que a Resolução 125/2010 apresenta grande relevância na conjuntura processual brasileira, inclusive como marco normativo para a instituição de um novo paradigma voltado para a solução consensual de conflitos de interesse, sendo que o cenário de surgimento da referida Resolução é marcado pela constatação de uma crise do Poder Judiciário, que buscava encontrar solução para a morosidade, falta de eficiência e elevados gastos para sua manutenção.
Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure.
Authors: Juhlin L , Olsson MJ.
Published: June 2023

The aim of this 2-year study was to test the hypothesis that folic acid, vitamin B12 and sun exposure could be helpful in treating vitiligo. One hundred patients with vitiligo were treated with oral folic acid and vitamin B12 after being informed that sun exposure might enhance repigmentation. They were requested to keep a record of sun exposure in summer and UVB irradiation in winter. The minimal treatment time suggested was 3-6 months but should be longer if improvement was achieved. Clear repigmentation occurred in 52 patients, including 37 who exposed their skin to summer sun and 6 who used UVB lamps in winter. Repigmentation was most evident on sun-exposed areas, where 38% of the patients had previously noted repigmentation during summer months. Total repigmentation was seen in 6 patients. The spread of vitiligo stopped in 64% of the patients after treatment. Folic acid and vitamin B12 supplementation combined with sun exposure can induce repigmentation better than either the vitamins or sun exposure alone. Treatment should continue as long as the white areas continue to repigment. Further studies are needed to determine ideal minimal dosages of vitamins and UV exposure, as well as treatment time.
Dermal oedema in lipodermatosclerosis: distribution, effects of posture and compressive theraphy evaluated by high-frequency ultrasonography.
Authors: Gniadecka M
Published: June 2023

Although leg oedema is believed to contribute to the pathogenesis of lipodermatosclerosis and leg ulcer, little is known about the cutaneous distribution of water in lipodermatosclerosis. In lipodermatosclerosis accompanied by leg ulceration, a subepidermal low echogenic band is seen in the high-frequency echograms of the skin at the boundary of the wound. Since skin echogenicity is inversely related to the amount of water contained, it has been assumed that the subepidermal low echogenic band corresponds to oedema in the papillary dermis. In this study we evaluated dermal oedema in lipodermatosclerosis by quantifying changes of skin echogenicity in 20 patients with lipodermatosclerosis and 20 age- and sex-matched controls. In order for us to evaluate the influence of the upright posture on skin water content, echogenicity was determined three times a day in various regions of the lower and upper extremities. Next morning, after ultrasound examination of the ankle skin, a compressive stocking was applied for 12 h and then the measurements of echogenicity were repeated. At any time of the day, ankle and calf skin was less echogenic in lipodermatosclerosis than in the control. The low echogenic area was confined to the subepidermal region. During the day the low echogenic area expanded in patients with lipodermatosclerosis. This phenomenon was reversed by leg compression. These results indicate that in lipodermatosclerosis oedema is located mainly in the papillary skin. An upright position causes aggravation of oedema, whereas application of compression protects against accumulation of water in the skin during the day.
Selective increase of IgA rheumatoid factor in patients with gluten sensitivity.
Authors: Sökjer M , Jónsson T , Bödvarsson S , Jónsdóttir I , Valdimarsson H
Published: June 2023

An increased prevalence of raised autoantibodies, including rheumatoid factor, has been reported in patients with gluten sensitivity. However, rheumatoid factor has only been measured in small groups of patients and the findings have been conflicting. In this study IgM, IgG and IgA rheumatoid factor was measured in 89 patients with dermatitis herpetiformis and 22 patients with coeliac disease and compared with 89 normal controls. There was an increased prevalence of elevated IgA rheumatoid factor in the patients with dermatitis herpetiformis (13.5% p = 0.036) and coeliac disease (18.2% p = 0.078), while no such increase was found for the IgM or IgG rheumatoid factor isotypes. This selective increase of IgA rheumatoid factor suggests that rheumatoid factor production in patients with gluten sensitivity primarily results from immunological activation in the gut mucosa.
Efficacy of cetirizine in cholinergic urticaria.
Authors: Zuberbier T , Aberer W , Burtin B , Rihoux J P , Czarnetzki B M
Published: June 2023

In order to examine the efficacy of cetirizine in cholinergic urticaria, we studied 24 patients in a double-blind crossover design during 3-week treatment periods, with either 10 or 20 mg/d cetirizine or placebo. The placebo period was always placed in between the two verum treatments to allow for a washout of the drug. Evaluation of the patients' daily symptom scores based on itching, erythema and whealing showed a highly significant improvement (p < 0.01). The percentage of days with mild or no symptoms was also increased significantly with the drug (p < 0.05). Except for whealing (p < 0.05), no significant differences between the two dosages of cetirizine could be determined. Since antihistamines have previously been shown to be frequently unsatisfactory in the treatment of cholinergic urticaria, the present data are encouraging regarding the control of symptoms in this condition.
Atypical mycobacterial cervical lymphadenitis associated with Sweet's syndrome.
Authors: Hsiao G H , Chiu H C
Published: June 2023

We report the case of a 52-year-old woman with a non-tuberculous (atypical) mycobacterial cervical lymphadenitis, caused by Mycobacterium fortuitum, in association with Sweet's syndrome. The cervical lymphadenitis was resistant to medical treatment, and the Sweet's syndrome occurred intermittently. Systemic steroid treatment was required to control the cutaneous symptoms.
The Psoriasis Life Stress Inventory: a preliminary index of psoriasis-related stress.
Authors: Gupta M A , Gupta A K
Published: June 2023

The psychosocial impact of psoriasis may result in significant daily stress for the patient. We present a questionnaire, the Psoriasis Life Stress Inventory (PLSI), which provides a rating of psoriasis-related stress. Two hundred and seventeen psoriasis patients endorsed a list of psoriasis-related items they had experienced over the previous one month and rated the degree of stress associated with each item on a 4-point scale. The final version of the PLSI consisted of 15 items, each of which had been endorsed by at least 15% of patients. A PLSI score of > or = 10 (range 0 to 43) delineated patients with greater overall psoriasis severity (p = 0.007), more cosmetically disfiguring psoriasis (p < 0.01), greater number of flare-ups of psoriasis (p = 0.009) and greater pruritus severity (p = 0.001). This preliminary instrument provides a clinically useful index of psoriasis-related stress and needs to be tested among patients from different centers and in prospective studies.
Seasonal variation of tyrosinase activity in serum.
Authors: Sonesson B , Eide S , Rorsman H , Rosengren E
Published: June 2023

Serum samples for the analysis of tyrosinase activity were obtained from 10 healthy subjects in autumn, winter and summer. Tyrosinase was purified from 100 microl serum by adsorption to concanavalin A sepharose, the tyrosinase adsorbed to the gel being separated from other components by centrifugation. The gel was suspended in a buffer containing 5-hydroxy-indole-3-acetic acid as an antioxidant and incubated for 2 min with L-cysteine and D-L-dopa at 37 degrees C. The 5-S-L-cysteinyl-L-dopa formed was measured by HPLC and electrochemical detection. Tyrosinase has high stereo-specificity for the L-enantiomer of dopa, and correction for non-specific oxidation was made by simultaneous measurement of 5-S-L-cysteinyl-D-dopa formed from D-dopa. Whereas the oxidation of L-dopa catalysed by tyrosinase ws inhibited by L-tyrosine, the non-specific oxidation of D-dopa was not. Mean serum tyrosinase activity was 0.9 nkatal/l in summer, 0.8 nkatal/l in autumn and 0.4 nkatal/l in winter. The range of tyrosinase activity was much higher in summer and autumn than in winter.
Retinoids and fibrinolysis.
Authors: Bäck O , Nilsson T K
Published: June 2023

Vitamin A and its analogues have been reported to increase the release of tissue plasminogen activator in vitro. The aim of the present study was to reevaluate these findings and to investigate whether retinoids in doses used in dermatological therapy could enhance the release of endothelial fibrinolytic factors. Our results showed that endothelial cells incubated in vitro with retinoic acid increased the release of tissue plasminogen activator to the supernatant without concomitant secretion of plasminogen activator inhibitor-1. In patients treated with isotretinoin or etretinate these findings were confirmed, showing enhanced baseline tissue plasminogen activator concentrations in plasma in association with unchanged levels of plasminogen activator inhibitor-1 and von Willebrand factor. These findings are consistent with chronically augmented tissue plasminogen activator secretion without evidence of endothelial cell damage and may be of importance for the interpretation of the safety of lon-term therapy with regard to retinoid-induced hyperlipemia and the development of cardiovascular disease.
Pityrosporum ovale extracts increase interleukin-4, interleukin-10 and IgE synthesis in patients with atopic eczema.
Authors: Kröger S , Neuber K , Gruseck E , Ring J , Abeck D
Published: June 2023

Evidence for a possible role of the lipophilic yeast Pityrosporum ovale in the pathophysiology of atopic eczema has been found both in laboratory and therapeutical studies. Positive type I prick test reactions to P. ovale correlate with the intensity of eczematous skin lesions in the head and neck regions of patients with atopic eczema. Furthermore, antifungal treatment has been shown to be helpful in atopic eczema. In the present study the effect of P. ovale on IgE synthesis and cytokine production (IL-2, IFN gamma, IL-4, IL-10) was investigated in patients with atopic eczema, in vitro. Eight patients with atopic eczema were studied
Effects of gemfibrozil (Lopid) on hyperlipidemia in acitretin-treated patients. Results of a double-blind cross-over study.
Authors: Vahlquist C , Olsson A G , Lindholm A , Vahlquist A
Published: June 2023

Hyperlipidemia is a common side-effect of oral retinoid treatment, which sometimes interferes with long-term therapy. To evaluate the safety and efficacy of the lipid-lowering drug gemfibrozil on retinoid-associated hyperlipidemia, we studied the clinical response and the plasma lipoprotein levels in 22 acitretin-treated (0.25-0.75 mg/kg) patients mainly suffering from psoriasis. Gemfibrozil or placebo was given in a double-blind cross-over fashion to 14 patients, who after 8 weeks of acitretin therapy and dietary advice exhibited hyperlipidemia (triglyceride levels > or = 50% above baseline and/or > or = 2.0 mmol/l). Serum triglycerides remained high (3.7 +/- 2.4 mmol/l) during placebo treatment but were reduced after 8 weeks of gemfibrozil treatment (p < 0.01). The total cholesterol level decreased slightly (p < 0.05) during gemfibrozil treatment, but the LDL/HDL ratio did not change significantly. No untoward effects of gemfibrozil on acitretin dose-response and clinical side-effects were noted. Gemfibrozil thus appears useful in patients prone to retinoid-induced hyperlipidemia unresponsive to dietary treatment and acitretin dose reductions.
UVB versus UVB plus calcipotriol (MC 903) therapy for psoriasis vulgaris.
Authors: Kokelj F , Lavaroni G , Guadagnini A
Published: June 2023

It is well known that UVB therapy of psoriasis vulgaris is potentiated by the association with topical and oral drugs, while till now there have been very few reports on the association between UVB and calcipotriol. In order to evaluate the efficacy and tolerance of this association, we studied 19 patients with psoriasis vulgaris of mild severity (PASI: 5-10). Each patient was treated with UVB and invited to apply calcipotriol 50 micrograms/g ointment twice a day on one lesion usually on elbows or knees in order to compare it with the opposite side. The evaluation of each lesion was performed before and after 4 weeks of therapy. Our data show that the association between UVB and calcipotriol is significantly more effective than UVB therapy alone: 17 out of 19 patients (89%) showed a greater improvement with UVB plus calcipotriol as compared to UVB alone.
Epidermal proliferation is not impaired in chronic venous ulcers.
Authors: Andriessen M P , Van Bergen B H , Spruijt K I , Go I H , Schalkwijk J , Van de Kerkhof PC
Published: June 2023

In this study we have investigated epidermal growth and differentiation during wound healing in human skin. The studies were performed in excisional wounds in normal skin and in chronic venous ulcers. Tissues were analyzed by immunohistochemical staining for proliferation-associated nuclear antigens (PCNA and Ki-67 antigen) and cytokeratin 16. Healing of excisional wounds was studied from day 2 to 14. Recruitment of resting (G0) epidermal cells started within 2 days after wounding
Topical antimycotic treatment of atopic dermatitis in the head/neck area. A double-blind randomised study.
Authors: Broberg A , Faergemann J
Published: June 2023

In order for us to evaluate the effect of topical antimycotic treatment in patients with atopic dermatitis affecting the head and neck area, 60 patients (36 females and 24 males range 14-53 years) were included in a double-blind study during 6 weeks. Of the 53 evaluable patients, 55% had positive skin prick tests to Pityrosporum ovale. In addition to oral antibiotic treatment, patients in group A (n = 26) were given miconazole-hydrocortisone cream and ketoconazole shampoo, whereas patients in group B (n = 27) were given hydrocortisone cream and placebo shampoo. At the start of the study P. ovale cultures were positive in 83% of all patients (no significant difference between the groups). After 4 weeks of treatment, there was a decrease in P. ovale colonisation in group A (p < 0.001) but not in group B. Patients in both groups improved (p < 0.001). The decrease in eczema score did not differ between group A and group B after 4 weeks' treatment. A further decrease of the eczema score was seen in both groups at the end of the study, but no difference was found between the groups.
Acro-angiodermatitis: review of the literature and report of a case.
Authors: Rashkovsky I , Gilead L , Schamroth J , Leibovici V
Published: June 2023

Acro-angiodermatitis is a very common disorder, with a close clinical, anatomical and morphological resemblance to Kaposi's sarcoma. Several types of this disorder can be found in different settings. However, these conditions are often misdiagnosed and therefore mistreated. A review of the literature and a classification of all types of acro-angiodermatitis are presented. We also describe a case of a patient with acro-angiodermatitis which completely regressed following a course of dapsone combined with leg elevation and elastic support stockings.
Cutaneous adverse reactions after intra-articular injection of triamcinolone acetonide.
Authors: Ijsselmuiden O E , Knegt-Junk K J , Van Wijk R G , VaNJoost T
Published: June 2023

A patient is described with a disseminated morbilliform and partially persistent urticarial dermatitis following intra-articular injections of triamcinolone acetonide. A delayed-type hypersensitivity to triamcinolone acetonide was observed after patch and intradermal testing. However, an immediate-type hypersensitivity to this drug was not observed. A delayed-type sensitization to betamethasone, dexamethasone and prednisolone, but not to hydrocortisone was also observed after patch testing. Intradermal tests with these representatives of corticosteroids were all negative. Although little is known yet about the relationship between immediate and delayed-type hypersensitivity and the side-effects of oral use of corticosteroids, the absence of positive skin tests to corticosteroids other than triamcinolone acetonide may indicate a safe use of these drugs orally or via injection.
Intracutaneous transport of orally administered fluconazole to the stratum corneum.
Authors: Faergemann J , Godleski J , Laufen H , Liss R H
Published: June 2023

Fluconazole administered at 150 mg/week for 1-5 weeks is effective orally against dermatophytes and yeast in stratum corneum. Clinical and mycological cure rates approach 90%, but the precise distribution of the drug within various layers of skin is uncertain. We administered fluconazole at 150 mg/week for 2 weeks to 5 volunteers. Distribution of fluconazole in biopsies of skin was imaged by energy dispersive analysis of X-rays (EDX) and transmission electron microscopy, and in cells by electron energy-loss spectroscopy (EELS). Eight hours after a second dose, EDX showed fluconazole highest and homogeneously distributed in stratum corneum, lower in the rest of the epidermis, and lowest in dermis. The highest fluconazole levels detected by EELS were in cytoplasmic inclusions of sweat and sebaceous glands and less in keratinocytes and dermal collagen. We conclude that fluconazole delivered to stratum corneum by direct diffusion from capillaries and in sweat is also in all likelihood transported in sebum.
Increased concentration of beta-endorphin in the sera of patients with severe atopic dermatitis.
Authors: Glinski W , Brodecka H , Glinska-Ferenz M , Kowalski D
Published: June 2023

Serum beta-endorphin was measured by radioimmunoassay in 25 patients with atopic dermatitis and 100 healthy subjects. The neuropeptide was found to be markedly (p < 0.001) increased in patients with atopic dermatitis (9.2 +/- 3.4 pg/ml) as compared to normal controls (6.1 +/- 1.5 pg/ml). A correlation between increased serum beta-endorphin concentration and some clinical parameters of the disease has been found. The statistically significant elevation of beta-endorphin was found in patients with widespread atopic dermatitis lesions involving more than 20% of the skin surface (11.1 +/- 3.6 pg/ml), a high disease severity score (10.7 +/- 3.7 pg/ml), and previous bronchial asthma symptoms (11.6 +/- 3.1 pg/ml). A possible explanation of increased beta-endorphin is either its generation in atopic dermatitis lesions by inflammatory cells or activation of pituitary-adrenal axis by psychoneural factors in the mechanism of chronic stress.
Soluble Pityrosporum-derived chemoattractant for polymorphonuclear leukocytes of psoriatic patients.
Authors: Bunse T , Mahrle G.
Published: June 2023

The chemoattraction of polymorphonuclear leukocytes (PMNs) from psoriatic patients, atopic patients and healthy control persons by Pityrosporum orbicularelovale was investigated using the Boyden chamber method. The chemotactical attraction of PMNs from psoriatic patients by Pityrosporum (stimulation index SI = 58 +/- 50) was significantly increased (p < 0.05) compared to PMNs from atopic patients (SI = 20 +/- 17) and control persons (SI = 26 +/- 24). This effect seems to be specific for Pityrosporum, since the chemotactical response to Staphylococcus epidermidis was not increased in psoriasis. The chemotactical factor produced by Pityrosporum is hydrophilic and is destroyed by acid hydrolysis, indicating its protein nature. The yeast Pityrosporum may thus play a role in the koebnerization of psoriasis.
Normolipidemic xanthelasma palpebrarum: lipid composition, cholesterol metabolism in monocyte-derived macrophages, and plasma lipid peroxidation.
Authors: Bergman R , Kasif Y , Aviram M , Maor I , Ullman Y , Gdal-On M , Friedman-Birnbaum R.
Published: June 2023

The lipid compositions of 8 normolipidemic xanthelasma palpebrarum (XP) lesions were analyzed using thin-layer chromatography, with the adjacent uninvolved skin used as control. The lesions were found to be composed predominantly of cholesterol, mostly cholesteryl ester, whereas in the control specimens phospholipids predominated. The degradation rates of 125I-low-density lipoprotein (LDL), oxidized LDL, and acetyl LDL, and the rates of intracellular cholesterol synthesis from 1,2-(14)C-acetate, in blood monocyte-derived macrophages (MDM) from 3 normolipidemic patients, were similar to those of MDM from 3 normal control subjects. The mean levels of lipid peroxides and conjugated dienes under basal conditions, as well as following the addition of a free radical-generating compound (2,2-azobis-2-amidinopropane hydrochloride) to the plasma of 14 normolipidemic XP patients were significantly higher than those of 14 age- and sex-matched normal controls. We conclude that the predominant lipid accumulated in normolipidemic XP lesions is cholesteryl ester, but there is no evidence for intrinsic cellular cholesterol metabolism derangement in blood MDM from patients which could account for this. Since macrophage cholesterol accumulation can also result from enhanced uptake of increased levels of oxidized LDL, the increased plasma lipid peroxidation (derived from oxidized LDL) might lead to accumulation of cholesterol in macrophages and formation of foam cells via this mechanism.
Expression of heat shock protein 72 on peripheral blood mononuclear cells from patients with pustulosis palmaris et plantaris.
Authors: Tamada Y , Takama H , Yokochi K , Ikeya T , Yokochi T , Matsumoto T.
Published: June 2023

The expression of heat shock protein (HSP) 72 on peripheral blood mononuclear cells (PBMC) from patients with pustulosis palmaris et plantaris (PPP) was studied. PBMC isolated freshly from patients with PPP expressed HSP72, while those from psoriasis patients did not. PBMC from patients with PPP continued to express it in in vitro cultures at 37 degrees C. This expression was further augmented by in vitro heat stimulation at 43 degrees C. Immunofluorescence studies showed that approximately 20% of PBMC from patients with PPP were stained positively with anti-HSP72 antibody. HSP72 was expressed on both nonadherent and adherent cells of PBMC. These findings suggest that PBMC from patients with PPP may produce HSP72 spontaneously through their in vivo exposure to stressful agents.
Treatment of lichen simplex chronicus with topical capsaicin cream.
Authors: Kantor GR , Resnik KS.
Published: June 2023

No abstract available
Contact dermatitis after calcipotriol and patch test evaluation.
Authors: Molin L.
Published: June 2023

No abstract available
A case of Neumann type pemphigus vegetans showing reactivity with the 130 kD pemphigus vulgaris antigen.
Authors: Ohata Y , Komiya H , Kawahara Y , Watanabe K , Nishikawa T , Hashimoto T.
Published: June 2023

No abstract available
Interleukin-8 immunoreactivity in malignant tumours of the skin.
Authors: Bornscheuer E , Schröder JM , Christophers E , Sticherling M.
Published: June 2023

In the past, interleukin-8 (IL-8) could be demonstrated within keratinocytes in normal epidermis and inflammatory skin diseases, like psoriasis and eczema. Using monoclonal antibodies, the distribution of IL-8 immunoreactivity was inversely related to the density of inflammatory infiltrate. Other in vitro observations indicated IL-8 to be a growth factor for keratinocytes. These results prompted an immunohistochemical examination of IL-8 immunoreactivity in malignant and semimalignant epithelial tumours of human skin. Whereas IL-8 could not be detected within the transformed cells of epithelial tumours or melanoma, some tumour cells within well differentiated squamous cell carcinoma and Bowen's disease showed IL-8 immunoreactivity. Thus, loss of IL-8 immunoreactivity can be a sign of malignant transformation. This indicates an important role in growth regulation as well as terminal differentiation of human keratinocytes.