bluuebunny/crossref_metadata_2025 huggingface dataset:
Selectivity and Sustainability of Electroenzymatic Process for Glucose Conversion to Gluconic Acid
Authors: Varničić Miroslava , Zasheva Iva N. , Haak Edgar , Sundmacher Kai , Vidaković-Koch Tanja
Published: March 2020

Electroenzymatic processes are interesting solutions for the development of new processes based on renewable feedstocks, renewable energies, and green catalysts. High-selectivity and sustainability of these processes are usually assumed. In this contribution, these two aspects were studied in more detail. In a membrane-less electroenzymatic reactor, 97% product selectivity at 80% glucose conversion to gluconic acid was determined. With the help of nuclear magnetic resonance spectroscopy, two main side products were identified. The yields of D-arabinose and formic acid can be controlled by the flow rate and the electroenzymatic reactor mode of operation (fuel cell or ion-pumping). The possible pathways for the side product formation have been discussed. The electroenzymatic cathode was found to be responsible for a decrease in selectivity. The choice of the enzymatic catalyst on the cathode side led to 100% selectivity of gluconic acid at somewhat reduced conversion. Furthermore, sustainability of the electroenzymatic process is estimated based on several sustainability indicators. Although some indicators (like Space Time Yield) are favorable for electroenzymatic process, the E-factor of electroenzymatic process has to improve significantly in order to compete with the fermentation process. This can be achieved by an increase of a cycle time and/or enzyme utilization which is currently low.
Influence of the Method of Preparation of the Pd-Bi/Al2O3 Catalyst on Catalytic Properties in the Reaction of Liquid-Phase Oxidation of Glucose into Gluconic Acid
Authors: Sandu Mariya P. , Sidelnikov Vladimir S. , Geraskin Andrej A. , Chernyavskii Aleksandr V. , Kurzina Irina A.
Published: March 2020

Gluconic acid and its derivatives are extensively used in pharmaceutical, food, textile, and pulp and paper branches of industry during production of food additives, cleansers, medicinal drugs, stabilizers, etc. To obtain gluconic acid, the method of conversion of glucose into gluconic acid by molecular oxygen in the presence of solid catalysts is promising. The process of obtaining Pd and bimetallic nanoparticles Pd-Bi, coated on Al2O3, has been considered in the work. Samples were prepared by combined and successive impregnation of the Al2O3 support using metalloorganic precursors Pd(acac)2, Bi(ac)3, and dissolved in an organic solvent (acetic acid), followed by the removal of excess solvent. To achieve the formation of Pd and bimetallic nanoparticles Pd-Bi on the substrate surface, the synthesized samples were subjected to thermal decomposition sequentially in the atmosphere of Ar, O2, and H2. The surface of the obtained catalysts was studied by a combination of physicochemical methods of analysis. The catalysts were analyzed in the reaction of liquid phase oxidation of glucose. The best results are achieved in the presence of the catalyst obtained by combined impregnation.
Virgin Heavy Gas Oil from Oil Sands Bitumen as FCC Feed
Authors: Ng Siauw H. , Heshka Nicole E. , Zheng Ying , Ling Hao , Wang Jinsheng , Liu Qianqian , Little Edward , Ding Fuchen , Wang Hui
Published: March 2020

This study deals with a systematic investigation of the fluid catalytic cracking (FCC) performance of a bitumen-derived virgin heavy gas oil (HGO) in the presence of its counterpart from bitumen-derived synthetic crude oil (SCO). The objective is to determine the amelioration effect on yield and product slate by the addition of the premium SCO HGO. The 343–525 °C cut virgin bitumen HGO was obtained from distillation of a raw Athabasca oil sands bitumen. It was then blended with different amounts of the 343 °C+ fraction of commercial SCO. Four HGO blends were prepared containing 75, 64, 61, and 48 v% of SCO HGO. Each HGO blend, as well as 100% SCO HGO, were catalytically cracked at 500 and 520 °C using a bench-scale Advanced Cracking Evaluation (ACE) unit. The results show acceptable FCC performance of bitumen virgin HGO when an adequate amount of SCO HGO is added. However, the resulting liquid product may need some quality improvement before use. Several observations, including catalyst poisoning by feed nitrogen and the refractory nature of virgin HGO, are evident and help to explain some observed cracking phenomena.
Black TiO2 Thin Films Production Using Hollow Cathode Hydrogen Plasma Treatment: Synthesis, Material Characteristics and Photocatalytic Activity
Authors: Godoy Junior Armstrong , Pereira André , Gomes Marcilene , Fraga Mariana , Pessoa Rodrigo , Leite Douglas , Petraconi Gilberto , Nogueira Adailton , Wender Heberton , Miyakawa Walter , Massi Marcos , da Silva Sobrinho Argemiro
Published: March 2020

Black TiO2 materials have been quite widely explored due to their large solar absorption and superior photocatalytic activity. In this paper, the blackening process of titanium dioxide (TiO2) thin film using the hollow cathode hydrogen plasma (HCHP) technique is reported. First, pristine anatase TiO2 films were grown by magnetron sputtering onto silicon and cover glass substrates and then annealed at 450 °C for 2 h. Then, the as-grown TiO2 films were treated with HCHP for 15 min. The physical, chemical and morphological properties of the films were analyzed by profilometry, X-ray diffraction (XRD), UV-Vis spectrophotometry, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) techniques. Electrical and photocatalytic measurements were performed by four-point probe and methylene blue UV degradation assays, respectively. The results showed that the black TiO2 film is highly absorbent in the UV-visible region, has low electrical resistance and greater surface area compared to the non-treated TiO2 film. These properties of black TiO2 film, as well as its performance as a photocatalytic agent, were investigated, indicating the superior quality of this material in thin film form and the promising potential of the HCHP treatment to produce hydrogenated TiO2 in short process time.
Alterations in Glucose Metabolism During the Transition to Heart Failure: The Contribution of UCP-2
Authors: Kutsche Hanna Sarah , Schreckenberg Rolf , Weber Martin , Hirschhäuser Christine , Rohrbach Susanne , Li Ling , Niemann Bernd , Schulz Rainer , Schlüter Klaus-Dieter
Published: March 2020

The cardiac expression of the mitochondrial uncoupling protein (UCP)-2 is increased in patients with heart failure. However, the underlying causes as well as the possible consequences of these alterations during the transition from hypertrophy to heart failure are still unclear. To investigate the role of UCP-2 mechanistically, expression of UCP-2 was silenced by small interfering RNA in adult rat ventricular cardiomyocytes. We demonstrate that a downregulation of UCP-2 by siRNA in cardiomyocytes preserves contractile function in the presence of angiotensin II. Furthermore, silencing of UCP-2 was associated with an upregulation of glucose transporter type (Glut)-4, increased glucose uptake, and reduced intracellular lactate levels, indicating improvement of the oxidative glucose metabolism. To study this adaptation in vivo, spontaneously hypertensive rats served as a model for cardiac hypertrophy due to pressure overload. During compensatory hypertrophy, we found low UCP-2 levels with an upregulation of Glut-4, while the decompensatory state with impaired function was associated with an increase of UCP-2 and reduced Glut-4 expression. By blocking the aldosterone receptor with spironolactone, both cardiac function as well as UCP-2 and Glut-4 expression levels of the compensated phase could be preserved. Furthermore, we were able to confirm this by left ventricular (LV) biopsies of patients with end-stage heart failure. The results of this study show that UCP-2 seems to impact the cardiac glucose metabolism during the transition from hypertrophy to failure by affecting glucose uptake through Glut-4. We suggest that the failing heart could benefit from low UCP-2 levels by improving the efficiency of glucose oxidation. For this reason, UCP-2 inhibition might be a promising therapeutic strategy to prevent the development of heart failure.
Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor
Authors: Seo Hye-Young , Lee So-Hee , Lee Ji-Ha , Kang Yu Na , Hwang Jae Seok , Park Keun-Gyu , Kim Mi Kyung , Jang Byoung Kuk
Published: March 2020

The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis. This study investigated whether the inhibition of Src protects against liver fibrosis. The expression of Src was upregulated in thioacetamide (TAA)-induced fibrotic mouse liver and cirrhosis of patients, and phospho-Src was upregulated during activation of hepatic stellate cells (HSC). In addition, Src inhibition reduced the expression of α-smooth muscle actin (αSMA) in primary HSCs and suppressed transforming growth factor β (TGF-β)-induced expression of connective tissue growth factor (CTGF) in hepatocytes. Src inhibitor Saracatinib also attenuated TAA-induced expression of type I collagen, αSMA, and CTGF in mouse liver tissues. The antifibrotic effect of Src inhibitors was associated with the downregulation of Smad3, but not of signal transducer and activator of transcription 3 (STAT3). In addition, Src inhibition increased autophagy flux and protected against liver fibrosis. These results suggest that Src plays an important role in liver fibrosis and that Src inhibitors could be treat liver fibrosis.
Aspirin Mitigated Tumor Growth in Obese Mice Involving Metabolic Inhibition
Authors: Wang Jiaan-Der , Chen Wen-Ying , Li Jian-Ri , Lin Shih-Yi , Wang Ya-Yu , Wu Chih-Cheng , Liao Su-Lan , Ko Chiao-Chen , Chen Chun-Jung
Published: March 2020

Obesity is associated with a wide range of chronic diseases, including cancer. It has been noted that the integration of metabolic mechanisms in obese patients may predispose them to suffer from cancer incidence and its progression. Thus, a better understanding of metabolic alterations in obesity, along with the development of feasible therapeutic approaches for intervention, are theoretically relevant to the prevention and treatment of cancer malignancy. Using a syngeneic tumor model involving Lewis Lung Carcinoma (LLC) cells and C57BL/6 mice fed with a high fat diet, obesity was found to be associated with dysregulated glucose and glutamine metabolism, inflammation, along with platelet activation and the promotion of tumor growth. Tumor-bearing lowered glucose levels while moderately increasing inflammation, platelet activation, and glutamine levels. The antiplatelet drug aspirin, mitigated tumor growth in obese mice, paralleled by a decrease in systemic glucose, insulin, inflammation, platelet activation, glutamine and tumor expression of cell proliferation, aerobic glycolysis, glutaminolysis, platelets, and leukocyte molecules. The anti- and pro-cell proliferation, aerobic glycolysis, and glutaminolysis effects of aspirin and glutamine were further demonstrated in a LLC cell study. Although there remains limitations to our experiments, glucose and glutamine metabolism are proposed targets for the anticancer effects of aspirin.
ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis
Authors: Huo Jianxin , Xu Shengli , Lam Kong-Peng
Published: March 2020

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various environmental stress. However, whether ASK1 plays a role in T cell receptor (TCR)-mediated apoptosis of thymocytes is unclear. Here, we show that ASK1 is activated upon TCR stimulation and plays an important role in TCR-mediated apoptosis of thymocytes by triggering downstream JNK and p38 signaling cascades. Mechanistically, ASK1-JNK/p38 signaling leads to the upregulation of neuron-derived clone 77 (Nur77), a critical pro-apoptotic protein involved in TCR-mediated apoptosis of thymocytes. Furthermore, we demonstrate that the activation of ASK1 is negatively modulated by Akt upon TCR stimulation. Thus, our results identify a previously unappreciated signaling mechanism involving ASK1 in TCR-mediated apoptosis of thymocytes.
Effect of Heat Treatment of Martensitic Stainless Steel on Passive Layer Growth Kinetics Studied by Electrochemical Impedance Spectroscopy in Conjunction with the Point Defect Model
Authors: Bösing Ingmar , Marquardt Georg , Thöming Jorg
Published: March 2020

Martensitic stainless steels are widely used materials. Their mechanical and corrosion properties are strongly influenced by their microstructure and thereby can be affected by heat treatment. In the present study, the effect of different austenitizing temperatures on the passive film growth kinetics of martensitic stainless steel is studied by electrochemical impedance spectroscopy. The data was further fitted by the point defect model to determine kinetic parameters. We show that an increasing austenitizing temperature leads to a more protective passive film and slows down passive film dissolution in sulfuric acid.
Effect of Coating Process on Performance of Reversible Thermochromic Waterborne Coatings for Chinese Fir
Authors: Yan Xiaoxing , Wang Lin , Qian Xingyu
Published: March 2020

The effect of the coating process on the properties of reversible thermochromic waterborne coating on the surface of Chinese fir was examined. The results demonstrated that the most critical process parameter affecting the color difference and gloss of the coating was the way of adding thermochromic ink. The coating process had little influence on the adhesion, impact resistance adding, liquid resistance, and original properties of the coating. There was no obvious gloss variation in the coating under different coating processes. For the (3+3) layered coatings, when the thermochromic ink was added to the topcoats, the discoloration performance was the most obvious and the comprehensive performance of coating was better. Meanwhile, the gloss was 55.6%, the adhesion grade was grade 0, the impact resistance was 5.0 kg·cm, the liquid resistance grade of the coating to sodium chloride, ethanol and detergent was grade 1, and the liquid resistance grade to red ink was grade 3. The discoloration performance of the coating was stable under the conditions of aging and time change. This study provides new insight into preparing thermochromic intelligent waterborne wood coatings with potential practical applications on Chinese fir wood surfaces, and also lays a foundation for its application in furniture engineering.
Investigation on the Rapid Annealing of Ti-Au Composite Electrode on n-Type (111) CdZnTe Crystals
Authors: Shi Haozhi , Wang Shulei , Zhang Jijun , Shi Zhubin , Min Jiahua , Huang Jian , Wang Linjun
Published: March 2020

In this paper, the ohmic properties of Ti, Al, and Ti-Au composite electrodes on n-type (111) CdZnTe crystal deposited by vacuum evaporation method were first analyzed, and then the rapid annealing of Ti-Au electrode under Ar atmosphere with different temperature and time was explored. The ohmic property and barrier height were evaluated by current–voltage (I–V) and capacitance-voltage (C–V) measurements, and the adhesion strength of various electrodess to CdZnTe was compared. The Ti-Au electrode on CdZnTe showed the lowest leakage current and barrier height, and the highest adhesion strength among the three kinds of electrodes on (111) CdZnTe crystals. The rapid annealing of Ti-Au electrode under Ar atmosphere was proved to improve its ohmic property and adhesion strength, and the optimal annealing temperature and time were found to be 423 K and 6 min, respectively. The barrier height of the Ti-Au/CdZnTe electrode is 0.801 eV through rapid annealing for 6 min at 423 K annealing temperature, and the adhesion is 1225 MPa, which increases by 50% compared with that without rapid annealing.
Toward an Understanding of the Formation and Desolvation of Methanol Solvate, and Structure of Methanolysis Product: A Case Study of Nicosulfuron
Authors: Zhu Huaxiang , Zhang Bei , Wu Di , Cheng Xiaowei , Li Guiping , Xu Jun , Zhou Lina , Chen Wei
Published: March 2020

Nicosulfuron (NS) is a widely used sulfonylurea herbicide because of its high selectivity, broad spectrum of herbicide activity, and excellent performance. In this work, nicosulfuron methanol solvate (NS-MeOH) and [[3-[(Dimethylamino)carbonyl]-2-pyridinyl]sulfonyl]carbamic acid methyl ester (PCM) as a product of methanolysis of NS were obtained. Both of their structures were determined by a single crystal X-ray diffraction. A broad range of analytical techniques was applied to characterize the NS-MeOH, such as Powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and hot stage microscopy (HSM). Combined with the analysis of the Independent gradient model (IGM), Atom-in-molecules (AIM), and Hirshfeld surface (HS), direct insights into the role of solvent played in the formation of NS-MeOH and the mechanism of solid-to-solid phase transformation of NS-MeOH could be obtained. In addition, the aqueous solubility of NS was improved through the formation of NS-MeOH. A systematic investigation of herbicidal activity of NS and PCM was carried out. It was found that NS and NS-MeOH had similar herbicidal activities at the experimental concentrations while PCM exhibited significantly lower activity. It was suggested that methanolysis of the sulfonylurea bridge in the NS molecule exerted a great influence on the herbicidal activity.
A Novel Phenolic Foam-Derived Magnetic Carbon Foam Treated as Adsorbent for Rhodamine B: Characterization and Adsorption Kinetics
Authors: Zhang Yao , Wang Qiuyi , Li Ru , Lou Zhichao , Li Yanjun
Published: March 2020

In recent decades, dye wastewaters produced by dye-manufacturing and dye-consuming industries have become a growing water pollution problem. Herein, a novel phenolic foam-derived magnetic carbon foam is synthesized by in-situ pyrolysis of iron acetylacetonate (Fe(acac)3) containing phenolic resin and its corresponding application as an adsorbent for the removal of Rhodamine B from effluent is investigated. The characterization of the as-prepared adsorbent is carried out by SEM, EDS, XRD, XPS, VSM, FT-IR, Raman, and BET. The magnetic carbon foam is observed to consist of a CFe15.1/C matrix modified with α-Fe/Fe3C/Fe2O3 composites, possessing a 3D porous architecture formed by inter-connected cells with diameters of 50–200 μm and narrow ligaments with thicknesses of ~20 μm. Experimental tests demonstrate that the equilibrium of adsorption behavior of Rhodamine B onto the obtained adsorbent can be reached within 40 min and the corresponding maximum adsorption capacity is 258.03 mg/g. The effects of contact time and adsorbent dosage on the adsorption performance are investigated. Besides, four models are introduced to fit the experimental data to evaluate the adsorption kinetics. The overall rate constant is determined by the chemisorption process, according to the pseudo-second order adsorption kinetics mechanism. Besides, the pH effect on RhB adsorption onto magnetic carbon foam is investigated, with the pH values varying from 3 to 10. The above results prove the application prospect of magnetic carbon foam prepared in this work in dye wastewater treatment.
The Effect of Thermocycling and Surface Treatments on the Surface Roughness and Microhardness of Three Heat-Pressed Ceramics Systems
Authors: Vasiliu Roxana-Diana , Porojan Sorin-Daniel , Bîrdeanu Mihaela-Ionela , Uțu Ion-Dragoș , Porojan Liliana
Published: March 2020

Dental ceramic restorations are widely used in restorative dentistry. However, these restorations can be affected once cemented in the oral cavity by several factors. How can conventional surface treatments, such as glazing and mechanical polishing, diminish the effects of aging? The purpose of this in vitro study was to evaluate the effect of thermocycling and conventional surface treatments on the surface roughness and microhardness of three types of glass-ceramics by using a profilometer, scanning electron microscopy (SEM), atomic force microscopy (AFM), and a microhardness tester. Three types of ceramic systems (zirconia reinforced lithium silicate glass-ceramic, lithium disilicate glass-ceramic, and feldspathic glass-ceramic) (n = 48) were prepared. The samples were subjected to thermocycling for 10,000 cycles. Surface roughness was evaluated numerically using a profilometer and visually by using SEM and AFM. Microhardness was performed using a microhardness tester. The data were interpreted using the ANOVA test, and the results were correlated using Pearson’s correlation formula (r). Significant differences were found before and after thermocycling for the Ra (p < 0.01) and Rz (p < 0.05) parameters. As well, differences between glazed and polished surfaces were significant before and after thermocycling for surface roughness and microhardness (p < 0.05). A correlation was made between average surface roughness and microhardness (r = −460) and for the maximum surface roughness and microhardness (r = −606). Aging increases the roughness and decreases in time the microhardness. The tested ceramic systems behaved differently to the aging and surface treatments. Surface treatments had a significant impact on the microhardness and surface characteristics. The glazed groups were reported with higher surface roughness and lower microhardness when compared to the polished groups before and after thermocycling. The measuring roughness techniques determine the scale-dependent values for the Ra (Sa) and Rz (Sq) parameters. Thermocycling almost doubled the surface roughness for all the tested samples. Microhardness decreased only for the Celtra glazed samples. Nano-roughness increased the values for Vita and slightly for Emax. Thermocycling had little effect on Emax ceramic and a more significant impact on Celtra Press ceramic.
Preparation of Few-Layered Wide Bandgap MoS2 with Nanometer Lateral Dimensions by Applying Laser Irradiation
Authors: Mahdavi Mitra , Kimiagar Salimeh , Abrinaei Fahimeh
Published: March 2020

In this study, we report a new method for the quick, green, and one-step preparation of few-layered molybdenum disulfide (MoS2) nanosheets with wide bandgap. MoS2 nanosheets with small lateral dimension and uniform size distribution were synthesized for various applications. MoS2 powder was synthesized using the hydrothermal method; then, thinned by applying laser irradiation with different energies from 40 to 80 mJ. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), UV-Vis absorption spectra, and photoluminescence (PL) spectra were applied for the characterization of the MoS2 nanosheets in terms of morphology, crystal structures, and optical properties. The widest calculated bandgap 4.7 eV was for the sample under 80 mJ laser energy. The results confirmed the successful preparation of highly pure, uniform, and few-layered MoS2 nanosheets. Furthermore, it was possible to enhance the production rate of MoS2 nanosheets (including nanosheets and nanoparticles) through laser irradiation. Thus, the present paper introduces a simple and green alternative approach for preparing few-layered MoS2 nanosheets of transition metal dichalcogenides or other layered materials.
Seeded Mineralization in Silk Fibroin Hydrogel Matrices Leads to Continuous Rhombohedral CaCO3 Films
Authors: Wang Dan , Feng Yu-xuan , Li Ming , Guo Shengdi , Jiang Yuan
Published: March 2020

As many biominerals are formed in gel-like media, hydrogel-mediated mineralization is deemed as paradigms of biomineralization and ideal approaches to synthetic minerals with hierarchical architectures and related functions. Nevertheless, the long diffusion distance in hydrogels makes mineralization a diffusion-limited process, leading to isolated crystals instead of uniform hierarchical architectures. In the current study, seeded mineralization in silk fibroin hydrogel matrices is successful in delivering continuous rhombohedral CaCO3 films. Though the coverage of hydrogel matrices makes mineralization a diffusion-limited process, the presence of seed layers promotes the growth of uniform overlayers in proper conditions. The regulation of the solid content of hydrogels provides a rational route to rhombohedral architectures with tunable morphologies and thickness. In the course of mineralization, the hydrogel matrices are partially occluded in rhombohedral films as inter- and intra-crystalline constituents, as confirmed by scanning and transmission electron microscopy. Our study confirms the availability of synthesizing continuous mineralized films with hierarchical architectures and the structural gradient in hydrogel matrices via self-organized mineralization. These films with the occlusion of hydrogel constituents may exhibit significant strength and resilience, and their formation can deepen our mechanistic understanding of biomineralization proceeding in gel-like media.
Pathogenic PSEN1 Glu184Gly Mutation in a Family from Thailand with Probable Autosomal Dominant Early Onset Alzheimer’s Disease
Authors: Senanarong Vorapun , An Seong Soo A. , Giau Vo Van , Limwongse Chanin , Bagyinszky Eva , Kim SangYun
Published: March 2020

A pathogenic mutation in PSEN1 p.Glu184Gly was discovered in a Thai family with early onset Alzheimer’s disease (EOAD) as the first case in Asia. Proband patient presented memory impairment and anxiety at the age of 41 years. Family history was positive, since several family members were also diagnosed with dementia (father and grandfather). MRI in the patient revealed global cortical atrophy without specific lesions or lacuna infarctions. Extensive genetic profiling for 50 neurodegenerative disease related genes was performed by next generation sequencing (NGS) on the patient. PSEN1 Glu184Gly was previously reported in French families with frontal variant Alzheimer’s disease (AD). Interestingly, this mutation is located near the splicing site and could possibly result in abnormal cleavage of PSEN1 transcript. Furthermore, 3D models from protein structural predictions revealed significant structural changes, since glycine may result in increased flexibility of TM-III helix. Inter/intra-helical interactions could also be altered. In the future, functional studies should be performed to verify the probable role PSEN1 Glu184Gly in amyloid beta processing and pathogenicity.
Clinical versus Ultrasound Measurements of Hyomental Distance Ratio for the Prediction of Difficult Airway in Patients with and without Morbid Obesity
Authors: Petrișor Cristina , Trancă Sebastian , Szabo Robert , Simon Robert , Prie Adrian , Bodolea Constantin
Published: March 2020

Purpose: To describe the correlation between clinically measured hyomental distance ratio (HMDRclin) and the ultrasound measurement (HMDRecho) in patients with and without morbid obesity and to compare their diagnostic accuracy for difficult airway prediction. Methods: HMDRclin and HMDRecho were recorded the day before surgery in 160 consecutive consenting patients. Laryngoscopy was performed by a skilled anesthesiologist, with grades III and IV Cormack–Lehane being considered difficult views of the glottis. Linear regression was used to assess the correlation between HMDRclin and HDMRecho and receiver operating curve analysis was used to compare the performance of the two for predicting difficult airway. Results: The linear correlation between HMDRclin and HDMRecho in patients without morbid obesity had a Pearson coefficient of 0.494, while for patients with morbid obesity this was 0.14. A slightly higher area under the curve for HMDRecho was oberved: 0.64 (5%CI 0.56–0.71) versus 0.52 (95%CI, 0.44–0.60) (p = 0.34). Conclusion: The association between HMDRclin and HDMRecho is moderate in patients without morbid obesity, but negligible in morbidly obese patients. These might be explained by difficulties in palpating anatomical structures of the airway.
Exploring the Phase Space of Multi-Principal-Element Alloys and Predicting the Formation of Bulk Metallic Glasses
Authors: Gabski Mirko , Peterlechner Martin , Wilde Gerhard
Published: March 2020

Multi-principal-element alloys share a set of thermodynamic and structural parameters that, in their range of adopted values, correlate to the tendency of the alloys to assume a solid solution, whether as a crystalline or an amorphous phase. Based on empirical correlations, this work presents a computational method for the prediction of possible glass-forming compositions for a chosen alloys system as well as the calculation of their critical cooling rates. The obtained results compare well to experimental data for Pd-Ni-P, micro-alloyed Pd-Ni-P, Cu-Mg-Ca, and Cu-Zr-Ti. Furthermore, a random-number-generator-based algorithm is employed to explore glass-forming candidate alloys with a minimum critical cooling rate, reducing the number of datapoints necessary to find suitable glass-forming compositions. A comparison with experimental results for the quaternary Ti-Zr-Cu-Ni system shows a promising overlap of calculation and experiment, implying that it is a reasonable method to find candidates for glass-forming alloys with a sufficiently low critical cooling rate to allow the formation of bulk metallic glasses.
Concept Mapping, an Effective Tool for Long-Term Memorization of Anatomy—A Quasi-Experimental Research Carried out among 1st Year General Medicine Students
Authors: Nicoara Sergiu-Mihai , Szamoskozi Stefan-Emeric , Mitrea Delia-Alexandrina , Leucuta Daniel-Corneliu
Published: March 2020

This study is part of a doctoral thesis conducted at the Faculty of Psychology of Babes-Bolyai University in collaboration with the University of Medicine, both from Cluj-Napoca, Romania. The starting point of the study was based on the eternal question of the medical student—“How should I learn to manage to retain so much information?” This is how learning through conceptual maps and learning by understanding has been achieved. In the study, a number of 505 students from the Faculty of General Medicine were randomly selected and divided into groups, to observe changes in the grades they obtained when learning anatomy with the concept mapping method vs. traditional methods. Six months later, a retest was carried out to test long-term memory. The results were always in favor of the experimental group and were statistically significant (with one exception), most notably for the 6-month retesting. It was also observed that the language of teaching, different or the same as the first language, explains that exception, at least partially. Other results were taken into account, such as the distribution of bad and good grades in the two groups. Other parameters that influenced the obtained results and which explain some contradictory results in the literature are discussed. In conclusion, the use of conceptual maps is useful for most students, both for short and long-term memory.
Blind Source Separation for the Aggregation of Machine Learning Algorithms: An Arrhythmia Classification Case
Authors: Gajowniczek Krzysztof , Grzegorczyk Iga , Gostkowski Michał , Ząbkowski Tomasz
Published: March 2020

In this work, we present an application of the blind source separation (BSS) algorithm to reduce false arrhythmia alarms and to improve the classification accuracy of artificial neural networks (ANNs). The research was focused on a new approach for model aggregation to deal with arrhythmia types that are difficult to predict. The data for analysis consisted of five-minute-long physiological signals (ECG, BP, and PLETH) registered for patients with cardiac arrhythmias. For each patient, the arrhythmia alarm occurred at the end of the signal. The data present a classification problem of whether the alarm is a true one—requiring attention or is false—should not have been generated. It was confirmed that BSS ANNs are able to detect four arrhythmias—asystole, ventricular tachycardia, ventricular fibrillation, and tachycardia—with higher classification accuracy than the benchmarking models, including the ANN, random forest, and recursive partitioning and regression trees. The overall challenge scores were between 63.2 and 90.7.
A Novel Load Scheduling Mechanism Using Artificial Neural Network Based Customer Profiles in Smart Grid
Authors: Khalid Zubair , Abbas Ghulam , Awais Muhammad , Alquthami Thamer , Rasheed Muhammad Babar
Published: March 2020

In most demand response (DR) based residential load management systems, shifting a considerable amount of load in low price intervals reduces end user cost, however, it may create rebound peaks and user dissatisfaction. To overcome these problems, this work presents a novel approach to optimizing load demand and storage management in response to dynamic pricing using machine learning and optimization algorithms. Unlike traditional load scheduling mechanisms, the proposed algorithm is based on finding suggested low tariff area using artificial neural network (ANN). Where the historical load demand individualized power consumption profiles of all users and real time pricing (RTP) signal are used as input parameters for a forecasting module for training and validating the network. In a response, the ANN module provides a suggested low tariff area to all users such that the electricity tariff below the low tariff area is market based. While the users are charged high prices on the basis of a proposed load based pricing policy (LBPP) if they violate low tariff area, which is based on RTP and inclining block rate (IBR). However, we first developed the mathematical models of load, pricing and energy storage systems (ESS), which are an integral part of the optimization problem. Then, based on suggested low tariff area, the problem is formulated as a linear programming (LP) optimization problem and is solved by using both deterministic and heuristic algorithms. The proposed mechanism is validated via extensive simulations and results show the effectiveness in terms of minimizing the electricity bill as well as intercepting the creation of minimal-price peaks. Therefore, the proposed energy management scheme is beneficial to both end user and utility company.
Evaluation of Anomaly Detection of an Autoencoder Based on Maintenace Information and Scada-Data
Authors: Lutz Marc-Alexander , Vogt Stephan , Berkhout Volker , Faulstich Stefan , Dienst Steffen , Steinmetz Urs , Gück Christian , Ortega Andres
Published: March 2020

The usage of machine learning techniques is widely spread and has also been implemented in the wind industry in the last years. Many of these techniques have shown great success but need to constantly prove the expectation of functionality. This paper describes a new method to monitor the health of a wind turbine using an undercomplete autoencoder. To evaluate the health monitoring quality of the autoencoder, the number of anomalies before an event has happened are to be considered. The results show that around 35% of all historical events that have resulted into a failure show many anomalies. Furthermore, the wind turbine subsystems which are subject to good detectability are the rotor system and the control system. If only one third of the service duties can be planned in advance, and thereby the scheduling time can be reduced, huge cost saving potentials can be seen.
Study on Surface Condensate Water Removal and Heat Transfer Performance of a Minichannel Heat Exchanger
Authors: Liu Xiuli , Chen Hua , Wang Xiaolin , Kefayati Gholamreza
Published: March 2020

The condensate on the surface of the minichannel heat exchanger generated during air cooling substantially reduces the heat transfer performance as it works as an evaporator in the air-conditioning system. This has received much attention in scientific communities. In this paper, the effect of operating parameters on the heat transfer performance of a minichannel heat exchanger (MHE) is investigated under an evaporator working condition. An experimental MHE test system is developed for this purpose, and extensive experimental studies are conducted under a wide range of working conditions using the water-cooling method. The inlet air temperature shows a large effect on the overall heat transfer coefficient, while the inlet air relative humidity shows a large effect on the condensate aggregation rate. The airside heat transfer coefficient increases from 66 to 81 W/(m2·K) when the inlet air temperature increases from 30 to 35 °C. While the condensate aggregation rate on the MHE surface increases by up to 1.8 times when the relative humidity increases from 50% to 70%. The optimal air velocity, 2.5 m/s, is identified in terms of the heat transfer rate and airside heat transfer coefficient of the MHE. It is also found that the heat transfer rate and overall heat transfer coefficient increase as the air velocity increases from 1.5 to 2.5 m/s and decreases above 2.5 m/s. Furthermore, a large amount of condensate accumulates on the MHE surface lowering the MHE heat transfer. The inclined installation angle of the MHE in the wind tunnel effectively enhances heat transfer performance on the MHE surface. The experimental results provide useful information for reducing condensate accumulation and enhancing microchannel heat transfer.
Numerical Simulation of Coherent Structures in the Turbulent Boundary Layer under Different Stability Conditions
Authors: Laima Shujin , Ren Hehe , Li Hui , Ou Jinping
Published: March 2020

Coherent structures in the turbulent boundary layer were investigated under different stability conditions. Qualitative analyses of the flow field, spatial correlation coefficient field and pre-multiplied wind velocity spectrum showed that the dominant turbulent eddy structure changed from small-scale motions to large- and very-large-scale motions and then to thermal plumes as the stability changed from strong stable to neutral and then to strong unstable. A quantitative analysis of the size characteristics of the three-dimensional turbulent eddy structure based on the spatial correlation coefficient field showed that under near-neutral stability, the streamwise, wall-normal and spanwise extents remained constant at approximately 0.3 δ , 0.1 δ and 0.2 δ ( δ , boundary layer height), respectively, while for other conditions, the extent in each direction varied in a log-linear manner with stability; only the spanwise extent under stable conditions was also independent of stability. The peak wavenumber of the pre-multiplied wind velocity spectrum moves towards small values from stable conditions to neutral condition and then to unstable conditions; thus, for the wind velocity spectrum, another form is needed that takes account the effects of the stability condition.
Improving Fuel Economy of Spark Ignition Engines Applying the Combined Method of Power Regulation
Authors: Gutarevych Yurii , Mateichyk Vasyl , Matijošius Jonas , Rimkus Alfredas , Gritsuk Igor , Syrota Oleksander , Shuba Yevheniy
Published: March 2020

One of the disadvantages of spark ignition engines, whose power is regulated by throttling, is the increased fuel consumption at low loads and when the engine is idle. The combined method of engine power regulation by switching off the cylinder group and throttling working cylinders is one of the effective ways to improve fuel economy in the above-mentioned modes. This article presents the research results of the combined method of engine power regulation which can be realized by minor structural changes in operating conditions. The method implies the following: at low loads and at idle speed of the engine. Fuel supply to the group of cylinders is switched off with the simultaneous increase of the cyclic fuel supply in the working cylinders. The adequacy of the calculated results has been checked by the indication of operating processes in switched off and working cylinders. The research results of a six-cylinder spark ignition engine with the distributed gasoline injection using the combined power regulation system have been shown. The angles of opening the throttle which provides a non-shock transition from the operation with all cylinders to the operation with the cylinder group switched off have been determined.
Comparative Analyses of Energy Efficiency between on-Demand and Predictive Controls for Buildings’ Indoor Thermal Environment
Authors: Sung Lee-Yong , Ahn Jonghoon
Published: March 2020

Advanced thermal control technologies have been continuously developed to complement conventional models and algorithms to improve their performance regarding control accuracy and energy efficiency. This study analyses the strengths and weaknesses of simultaneous controls for the amount of air and its temperature by use of on-demand and predictive control strategies responding to two different outdoor conditions. The framework performs the comparative analyses of an on-demand model, which reacts immediately to indoor conditions, and a predictive model, which provides reference signals derived from data learned. Two models are combined to make a comparison of how much more efficient the combined model operates than each model when abnormal situations occur. As a result, when the two models are combined, its efficiency improves from 20.0% to 33.6% for indoor thermal dissatisfaction and from 13.0% to 44.5% for energy use, respectively. This result implies that in addition to creating new algorithms to cope with any abnormal situation, combining existing models can also be a resource-saving approach.
Solar Radiation Allocation and Spatial Distribution in Chinese Solar Greenhouses: Model Development and Application
Authors: Zhang Xiaodan , Lv Jian , Xie Jianming , Yu Jihua , Zhang Jing , Tang Chaonan , Li Jing , He Zhixue , Wang Cheng
Published: March 2020

Solar radiation is the sole energy source for Chinese solar greenhouse agriculture. A favorable light environment is the foundation of a desirable crop growth environment, and it is key in solar greenhouse design. In this study, a mathematical model is established to quantitatively evaluate the solar greenhouse light environment. The model was developed considering the greenhouse shape parameters, materials’ optical properties, and interior solar radiation evolution, including the beam radiation, diffuse radiation, and multi-reflection. The model was validated under different weather conditions, and the results reveal a mean percentage error of 1.67 and 10.30% for clear sunny weather and cloudy weather, respectively, and a determination coefficient of 0.9756. By using this model, the solar radiation allocation in a solar greenhouse was calculated to determine the solar radiation availability for the heat-storage north wall and the entire greenhouse, and the dynamical spatial distribution of the solar radiation was obtained to describe the light environment quality. These allow the optimization of the greenhouse lighting regulation and planting pattern. Moreover, several optimizing measures are derived according to the model for improving the low-light environment near the north wall and maximizing the north wall’s heat storage/release capacity in a solar greenhouse.
Aldehydes-Aided Lignin-First Deconstruction Strategy for Facilitating Lignin Monomers and Fermentable Glucose Production from Poplar Wood
Authors: Chen Tian-Ying , Ma Cheng-Ye , Min Dou-Yong , Liu Chuan-Fu , Sun Shao-Ni , Cao Xue-Fei , Wen Jia-Long , Yuan Tong-Qi , Sun Run-Cang
Published: March 2020

In this study, lignin with fine structures and facile enzymatic saccharifying residue were successively dissociated based on the lignin-first biomass deconstruction strategy. In the lignin-first process, aldehyde-protected lignin fractions were firstly isolated by acid-catalyzed dioxane extraction in the presence of formaldehyde (FA) and acetaldehyde (AA) and then analyzed by advanced nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatography (GPC). The optimized hydrogenolysis of the extracted lignin (LFA and LAA) resulted in a high yield (42.57% and 33.00%) of lignin monomers with high product selectivity (mainly 2,6-dimethoxy-4-propylphenol) (39.93% and 46.61%). Moreover, the cellulose-rich residues were saccharified into fermentable glucose for bioethanol production. The glucose yield of the substrate (RAA) reached to 75.12%, which was significantly higher than that (15.4%) of the substrate (RFA). In short, the lignin-first biomass deconstruction by adding AA is a promising and sustainable process for producing value-added products (energy and fine chemicals) from lignocellulosic biomass.
Decentralized Control Method of ISOP Converter for Input Voltage Sharing and Output Current Sharing in Current Control Loop
Authors: Kim Sung-Hun , Kim Bum-Jun , Park Jung-Min , Won Chung-Yuen
Published: March 2020

Input-Series-Output-Parallel (ISOP) converters, a kind of modular converter, are used in high-input voltage and high-output current applications. In ISOP converters, Input Voltage Sharing (IVS) and Output Current Sharing (OCS) should be implemented for stable operation. In order to solve this problem, this paper proposes a decentralized control method. In the proposed control, output current reference is changed according to the decentralized control characteristic in individual current control loops. In this way, the proposed control method is able to implement IVS and OCS without communication. Also, this method can be easily used in current control loops and has high reliability compared to conventional control methods that require communication. In this paper, the operation principle is described to elucidate the proposed control and a small signal model of an ISOP converter is also implemented. Based on the small signal model, IVS stability analysis is performed using pole-zero maps with varying coefficients and control gains. In addition, the current control loop is designed in a stable region. In order to demonstrate the proposed control method, a prototype ISOP converter is configured using full-bridge converters. The performance of IVS and OCS in an ISOP converter is verified by experimental result.
PD Plus Dynamic Pressure Feedback Control for a Direct Drive Stewart Manipulator
Authors: Zhang Chenyang
Published: March 2020

In order to ensure good dynamic characteristics, servo valve is usually adopted as the drive part of Stewart manipulator which causes huge power consumption, while direct drive electro-hydraulic servo system has the advantages of energy saving, simple structure, convenient installation, and low failure rate. But its dynamic characteristics are so poor that it can only be applied to occasions where quick response is not needed. On the consideration above, following works are done in this paper. Since current coupling exists in the control system based on the speed of the servo motor as the control input, the control system of the direct drive Stewart manipulator is established based on the current of the servo motor as the control input in which the current coupling can be solved. In order to improve the dynamic characteristics of the direct drive Stewart manipulator, a Proportion Differentiation (PD) plus dynamic pressure feedback control strategy is also put forward in this paper, which is verified by using a simulated hydraulically driven Stewart manipulator. Simulation results show that both dynamic coupling and current coupling are solved and the control strategy proposed in this paper can significantly increase the bandwidths of all degrees of freedom.