bluuebunny/crossref_metadata_2025 huggingface dataset:
An Ammonium Cation Included Dinuclear Cd(II) Complex and A Face-Shared Octahedral Dinuclear Cd(II) Complex with N2O Donor Tridentate Schiff base Ligand
Authors: Sarkar Mrinal
Published: September 2023

One face-shared octahedral Cd(II) complex and one ammonium cation included Cd(II) complex have been examined with the N2O donor monoanionic Schiff-base ligand 4-methyl-2,6-bis(((phenylmethyl)imino)methyl)phenol (HL) having a central phenoxide unit. The configuration of the cadmium coordination geometries is responsible for varying modes of ligand binding and structures. The gas phase geometry of complex 1 has been optimized by density functional theory. In CH3OH, the reaction between HL and Cd(NO3)2·4H2O in the presence of triethylamine produces a tris-L clipped face-shared octahedral dinuclear complex [Cd2(μ-L)3]·(OH) (1). Use of Cd(NO3)2·4H2O and NH4SCN in CH3OH in the absence of triethylamine leads to the synthesis of [Cd2(μ-L)2(μ1,1-NCS)(μ-NH4 +)(NCS)2] (2), which contains a NH4 + cation at its center. Changes in co-ligands have an ability to regulate the synthesis of these two Cd(II) complexes, effectively allowing selfassembly to be directed. Three types of bridges of Cd(OPh)3Cd and Cd(OPh)2(μ1,1-NCS)(μ- H4+)Cd in 1 and 2 are responsible for the Cd···Cd separations of 3.324 and 3.432 Å, respectively.
In vitro Antidiabetic and Anticancer Activity of Some Novel Diazenyl Benzene Sulphonamide Derivatives
Authors: SUNITHA K. , NAIR SMITHA , PALANISAMY P.
Published: September 2023

A series of novel 2-[(5-phenyl-1,3,4-thiadiazole-2-imino)substituted benzene]diazenyl benzene sulphonamide derivatives (VII)6-10 weresynthesized and FT-IR, 1H NMR, 13C NMR and GC-MS spectral data were used to investigate the structures of the synthesized sulphonamide derivatives. The antioxidant activity of 2-[(5-phenyl-1,3,4-thiadiazole-2-imino)substituted benzene]diazenyl benzene sulphonamide derivatives (VII)6-10 was done using DPPH technique. Compounds (VII)7 and (VII)9 displayed excellent antioxidant activity when compared to standard ascorbic acid. The in vitro antidiabetic activity on α-amylase and α-glucosidase studies indicated compound (VII)7 as promising inhibitor of α-amylase and α-glucosidase. The cytotoxic activity of the synthesized compound (VII)9 was tested against human colon (HCT-116), lung (A549), breast (MCF-7) cancer cell lines and fibroblast (L929) normal mouse lines. The results showed that compound (VII)9 has good cytotoxic activity.
Quem são os “Líderes Escolares”? Condições de gestão entre Japão, Alemanha e Reino Unido
Authors: Tsujino Kemma , Suematsu Hiroki
Published: September 2023

Neste estudo, são analisadas as estruturas de administração e gestão das escolas públicas no Japão, na Alemanha e no Reino Unido. Visto que existe uma lacuna considerável entre o sistema e a prática nesses países, assim, "Quem são os diretores das escolas?" pode constituir um tema de investigação não só importante, mas também urgente. Essa questão implica a importância de se concentrar na estrutura global do sistema de ensino público para além de uma "unidade" escolar. A reforma radical da gestão escolar é uma das agendas comuns entre estes países. A análise de documentos e o trabalho de campo são realizados a partir de perspectivas comuns a estes três países, tais como "reforma escolar", "autonomia escolar", "diferenças/semelhanças". Como resultado, são clarificadas as condições de gestão escolar e as estruturas de governança nestes três países. Embora os diretores japoneses tenham formal e legalmente mais autoridade para serem dirigentes escolares, a base substancial para a gestão escolar não é suficiente, existindo muitas limitações. Para compreender os "dirigentes escolares" alemães, há que analisá-los em relação aos princípios da "supervisão estatal da escola", da "autonomia escolar" e da "participação educativa" dos professores, pais e alunos.  No Reino Unido, as decisões em matéria de finanças, pessoal e currículo são tomadas pelo órgão diretivo. Com base na tomada de decisões, os diretores assumem o papel de Diretor Executivo. A estrutura de governança distribuída existe no ensino público em cada país, e há diversos atores que dirigem as escolas com diferentes responsabilidades.
O Desenho Universal para a Aprendizagem: Planear o Ensino-Aprendizagem-Avaliação para uma Escola Mais Inclusiva
Authors: Bonança Rita , Madureira Cristiana , Lima Louise
Published: September 2023

A educação inclusiva tem como principal propósito garantir a igualdade de oportunidades, de todo e qualquer aluno, em qualquer momento do seu percurso escolar. Desde 2018, Portugal tem vindo a ser um país pioneiro pelas mudanças introduzidas, a nível legal, no que se refere à inclusão, traçando um novo rumo com novas práticas e metodologias pedagógicas diferenciadas, por forma a ultrapassar as barreiras à aprendizagem no acesso ao currículo de cada um dos alunos. O presente artigo tem como objetivo articular os pressupostos do Desenho Universal para Aprendizagem (DUA) e os princípios de uma avaliação pedagógica em contexto de sala de aula. Apresenta-se, deste modo, um contributo que enfatiza a teoria e a prática para ultrapassar as dificuldades que ainda possam persistir na conceptualização do DUA e, consequentemente, na sua operacionalização. Para tanto, propõem-se diferentes referenciais e planificações, enquanto possibilidades, de modo a elevar a qualidade das estratégias de ensino aprendizagem avaliação, assentes no princípio da equidade da inclusão.
Pension Reform and Improved Employment Protection: Effects on Older Men’s Employment Outcomes
Authors: Kajitani Shinya , Kan Mari
Published: September 2023

This study examines the impacts of demand-side (the improved employment protection law) and supply-side (pension reform) government interventions on older male workers’ employment outcomes in Japan. To identify the effects of interventions implemented concurrently, we employ a difference-in-difference-in-differences (DDD) approach with variation in the bindingness of the revision of employment protection law as our specification strategy. Our results show that the revised employment protection law had a significant positive impact on employment. However, the results of the event study’s DDD model show that the treatment effects do not last over time.
A portable household detection system based on the combination of bidirectional LSTM and residual block for automatical arrhythmia detection
Authors: Huang Zeqiong , Yang Shaohua , Zou Qinhong , Gao Xuliang , Chen Bin
Published: September 2023

Objectives

Arrhythmia is an important component of cardiovascular disease, and electrocardiogram (ECG) is a method to detect arrhythmia. Arrhythmia detection is often paroxysmal, and ECG signal analysis is time-consuming and expensive. We propose a model and device for convenient monitoring of arrhythmia at any time.

Methods

This work proposes a model combining residual block and bidirectional long-term short-term memory network (BiLSTM) to detect and classify ECG signals. Residual blocks can extract deep features and avoid performance degradation caused by convolutional networks. Combined with the feature of BiLSTM to strengthen the connection relationship of the local window, it can achieve a better classification and prediction effect.

Results

Model optimization experiments were performed on the MIT-BIH Atrial Fibrillation Database (AFDB) and MIT-BIH Arrhythmia Database (MITDB). The accuracy simulation results on both long and short signal was higher than 99 %. To further demonstrate the applicability of the model, validation experiments were conducted on MIT-BIH Normal Sinus Rhythm Database (NSRDB) and the Long-Term AF Database (LTAFDB) datasets, and the related recognition accuracy were 99.830 and 91.252 %, respectively. Additionally, we proposed a portable household detection system including an ECG and a blood pressure detection module. The detection accuracy was higher than 98 % using the collected data as testing set.

Conclusions

Hence, we thought our system can be used for practical application.
Rescaling creatinine makes GFR estimation equations generally applicable across populations – validation results for the Lund-Malmö equation in a French cohort of sub-Saharan ancestry
Authors: Nyman Ulf , Björk Jonas , Delanaye Pierre , Lahens Alexandre , Pottel Hans , Vidal-Petiot Emmanuelle , Flamant Martin
Published: September 2023

Objectives

To make glomerular filtration rate (GFR) estimating equations applicable across populations with different creatinine generation by using rescaled serum creatinine (sCr/Q) where sCr represents the individual creatinine level and Q the average creatinine value in healthy persons of the same population.

Methods

GFR measurements (mGFR, plasma clearance of 51Cr-EDTA) were conducted in 964 adult Black Europeans. We established the re-expressed Lund-Malmö revised equation (r-LMR) by replacing serum creatinine (sCr) with rescaled creatinine sCr/Q. We evaluated the r-LMR equation based on Q-values of White Europeans (r-LMRQ-white; Q-values females: 62 μmol/L, males: 80 μmol/L) and Black Europeans (r-LMRQ-Black; Q-values females: 65 μmol/L, males: 90 μmol/L), and the European Kidney Function Consortium equation (EKFCQ-White and EKFCQ-Black) regarding bias, precision (interquartile range, IQR) and accuracy (percentage of estimates within ±10 % [P10] and ±30 % [P30] of mGFR).

Results

Median bias of r-LMRQ-White/r-LMRQ-Black/EKFCQ-White/EKFCQ-Black were −9.1/−4.5/−6.3/−0.9 mL/min/1.73 m2, IQR 14.7/14.5/14.5/15.6 mL/min/1.73 m2, P10 25.1 %/34.8 %/30.3 %/37.2 % and P30 74.2 %/84.1 %/80.6 %/83.6 %. The improvement of bias and accuracy when using proper Q-values was most pronounced in men. Similar improvements were obtained above and below mGFR 60 mL/min/1.73 m2 and at various age and BMI intervals, except for BMI<20 kg/m2 where bias increased, and accuracy decreased.

Conclusions

GFR estimating equations may be re-expressed to include rescaled creatinine (sCr/Q) and used across populations with different creatinine generation if population-specific average creatinine concentrations (Q-values) for healthy persons are established.
Insights From Informal Research Mentoring of Three University EFL Teachers
Authors: Yan Chunmei , Gong Wuming , Zou Chunyan , Li Jun
Published: September 2023

Research-practice nexus has been an ideal for higher education. However, research mentoring has been underexplored in both formal and informal formats. This study aimed to examine the effects of one-year-long informal research mentoring conducted by an experienced EFL teacher educator for three teaching-focused EFL teachers from three different universities. It found that the informal research mentoring generated three positive effects. It fueled the mentees’ research interest, raised their awareness of self-discipline and stress-coping strategies, and kindled their enthusiasm for constructing a collegial environment in their working contexts. Meanwhile, limitations also emerged associated with the mentees’ limited research engagement and productivity owing to personal and contextual factors as well as the problems with the informal mentoring relationships. Implications of the study are drawn to improve faculty research mentoring processes and outcomes.
Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes
Authors: Guo Haijun , Zhi Yunqing , Wang Kaijing , Li Na , Yu Danlei , Ji Zhonghua , Chen Bo
Published: September 2023

Acquired resistance to chemotherapeutic drugs in gallbladder cancer (GBC) results in therapy failure. This study is aimed to establish oxaliplatin (OXA)-resistant GBC cell lines and uncover their gene expression profiles. First, two OXA-resistant GBC cell lines (GBC-SD/OXA and SGC996/OXA) were established by gradually increasing the drug concentration, and the resistance index was 4–5. The two resistant cell lines showed slower proliferation and higher stemness, colony formation, and migration abilities. Epithelial mesenchymal transformation and increased levels of P-glycoprotein were also detected. Next RNA-sequence analysis identified 4,675 dysregulated genes (DGs) in resistant cells, and most of the 12 randomly selected DGs were verified to be consistent with the sequence results. Kyoto Encyclopedia of Genes and Genomes analysis indicated that several DGs were involved in resistance- and phenotype-related pathways, of which the activations of PD-L1 and ERK1/2 were both verified in resistant cell lines. In conclusion, this study is the first to report the gene expression profile of OXA-resistant GBC cells and provides a useful database for target development.
Broadband large-angle beam scanning with dynamic spin energy distribution based on liquid crystal cascaded bilayer metasurface
Authors: Zhao Huijun , Liu Jiayue , Jiang Songlin , Jiang Xinhao , Cheng Jierong , Ji Yunyun , Chang Shengjiang , Fan Fei
Published: September 2023

Dynamic manipulation of terahertz (THz) beams plays an important role in THz application systems. The PB metasurface provides an effective scheme for space separation and deflection of the spin beam. However, mirror symmetry locking of the conjugated spin states severely limits the versatility of the device. In this work, we demonstrate a liquid crystal (LC) cascaded bilayer metasurface that includes an LC layer, anisotropic metasurface, and PB metasurface. By controlling anisotropy and polarization conversion effects, dynamic spin asymmetric transmission is realized. Meanwhile, two different dynamic energy distribution processes are realized between the L and R state with the corresponding deflection side. The results show that the device achieves a large angular spatial dispersion within the frequency-angle scanning range of ±35° to ±75° corresponding to the broadband range of 0.6–1.1 THz. Moreover, it achieves a spin beam spatial separation with a maximum proportion of energy distribution greater than 26 dB, and the active modulation rate in the energy distribution process reaches 98 %. This work provides a dynamic THz spin conversion and efficient large-angle beam scanning, with important potentials in wavelength/polarization division multiplexing and frequency-scanning antenna for large-capacity THz wireless communication, radar, and imaging systems.
Diversity and structure of bacterial communities in saline and non-saline rice fields in Cilacap Regency, Indonesia
Authors: Hindersah Reginawanti , Pratiwi Etty , Fatma Yuli Siti , Simarmata Tualar
Published: September 2023

Increased concerns for sustainable agriculture have led to increased use of beneficial rhizobacteria as biofertilizers. Soil bacteria play a significant role in the nutrient cycle of soil, but their presence can be affected by abiotic stress, such as salinity. This study aimed to compare the chemical characteristics of slightly saline and non-saline rice soil and examine the bacterial community structure in both rhizosphere and bulk soil. We utilized 16SrRNA gene sequencing and performed arithmetic means clustering, a type of hierarchical clustering, on the samples collected from the rice fields of Cimrutu and Rawaapu Village in Cilacap Regency, Indonesia. Although the nutrient content was similar in both soils, there was a noticeable difference in their electrical conductivity (EC) despite the two locations being less than 4 km apart. The EC value in the Cimrutu soil suggests that it is non-saline, while the Rawaapu soil exhibits a low salinity level. The study found that Proteobacteria was the most prevalent phylum in saline rhizospheric soil. In contrast, Firmicutes was the most abundant group in saline bulk soil and non-saline rhizospheric and bulk soil. Additionally, Halothiobacillus, Thioalkalispira-Slvurivermis, and Acidothermus genera dominated the saline rhizospheric soil, suggesting that halotolerant microbes play a significant role as plant growth-promoting rhizobacteria in saline soil. The study provides valuable insights into cultured or uncultured bacterial populations and structure in saline and non-saline soil to develop future strategies related to salinity by introducing beneficial microbes.
Domestic Hybrids: Vitruvius’ Xenia, the Surrealist’s Minotaure, and Shrigley’s Octopus
Authors: Weir Simon
Published: September 2023

The domestic spaces of the built environment are traditionally associated with residential architecture. But the domestic spaces can also extend out, metaphorically, into familiar public spaces in which one may feel at home, and also extend inwards into self-perception, insofar as you may say that you dwell within yourself. This article begins by recalling Vitruvius’ fundamental notion of architectural utilitas concerns accommodating not a building’s owners but foreigners and strange outsiders. Vitruvius’ view on utility heavily favoured architecture’s socio-political function, and the guests he believed that architecture ought to accommodate were not merely a home’s owners or their visiting friends, but those people who are more distant from a home’s owners: those who are stranger and less well understood, known as xenos and who ought to be respected under the Ancient Greek religious and ethical principle of xenia. It is on these grounds that Vitruvius makes an ethical critique of residential architecture in favour of the virtue of public architecture. Next the reach of xenia is proposed to extend towards those who are different not merely because of ethnic differences but cognitive and sensory differences. Such accommodations are today accounted for as part of accessibility design and salutogenic design. Similar conceptions are noted in Nietzsche’s notion of an “architecture for the perceptive” and the surrealist’s interpretation of the minotaur as a hybrid not only of animal and human but a hybrid of civilised citizen and barbarian outsider. Together these sketch out an expanded sense of the domestic that includes public spaces designed to accommodate strange outsiders and the hybrid forms used to signify them.
PESQUISAS BRASILEIRAS SOBRE PROFESSORES INICIANTES NA EDUCAÇÃO INFANTIL
Authors: Nono Maévi Anabel
Published: September 2023

Apresenta-se, por meio de pesquisa bibliográfica, um mapeamento de estudos produzidos no Brasil, no período 1996-2018, que tratam da temática dos professores iniciantes na Educação Infantil. Buscou-se evidenciar contribuições desses estudos para subsidiar programas de apoio aos docentes que ingressam na profissão em creches e pré-escolas. De modo geral, as pesquisas analisadas trazem contribuições para compreensão de aspectos relacionados às vivências de docentes que ingressam na carreira na Educação Infantil. O levantamento indica a necessidade de estudos que investiguem programas de inserção à docência na Educação Infantil.
UMA ANÁLISE DAS PRÁTICAS PEDAGÓGICAS VOLTADAS PARA ESTUDANTES COM DISLEXIA A PARTIR DE UMA REFLEXÃO CINEMATOGRÁFICA
Authors: Castro Mirela Lopes de , Cavalcante Tícia Cassiany Ferro , Alves Viviany Andrea Meireles
Published: September 2023

Este artigo trata de uma análise do filme “Como estrelas na terra toda criança é especial” a partir de uma reflexão sobre as práticas pedagógicas e o olhar de afetividade do professor voltadas para as crianças com dislexia, relacionando-se com o contexto educacional brasileiro. Apresentamos as práticas pedagógicas que Nikumbh, professor de Ishaan, utiliza com o menino, trazendo a relevância de práticas específicas para as crianças com dislexia. Destacamos que a temática dislexia precisa ser amplamente discutida no âmbito educacional, para que comece a existir um olhar mais atento às especificidades desse público.
IMPRESSOS ESCOLARES E A RELIGIÃO CATÓLICA:
Authors: Lopez Gomes Cristian , Helena do Valle Pereira Assis Jacira
Published: September 2023

Este artigo tem como objetivo apresentar resultados de uma revisão sistemática no campo da História da Educação, referente a impressos escolares e sua vinculação com a religião católica. Na produção científica levantada, foram analisados os referenciais teóricos adotados, o enfoque dado e as regiões do país que abordavam essa temática. Na presente investigação, optou-se pela utilização do software de revisão sistemática Sumarize. Os resultados sinalizam que os referenciais mais mobilizados foram vinculados à História Cultural, e há forte presença dos conteúdos informados por uma perspectiva católica nos impressos escolares, sendo que essa concentração é maior na região sul do país.
PATRIMÔNIO HISTÓRICO- EDUCATIVO
Authors: Mendes Paulino Peterson , Antunes Silva Dilma , Santiago do Nascimento Ana Paula
Published: September 2023

Este artigo resulta de um Projeto de Extensão que teve como mote a celebração dos 50 anos do Núcleo de Educação Infantil – Escola Paulistinha de Educação, da Universidade Federal de São Paulo, em que propuséramos uma discussão sobre o processo de (re)construção histórica do patrimônio educativo dessa instituição. Para tanto, apresentamos um conjunto de materiais portadores de memória que, ao serem analisados crítica e reflexivamente, oferecem indícios sobre o funcionamento da escola, suas principais mudanças e permanências, sobre quem eram e como se relacionam seus sujeitos, e ratificam a importância da guarda e preservação da memória de instituições escolares
FONTES , HISTÓRIA MEMÓRIA DO CENTRO MUNICIPAL DE EDUCAÇÃO INFANTIL TIO PATINHAS DE MANDAGUARI/PR (1950-2000)
Authors: Sena Lioti Cláudia , Márcia Marlene Stentzler Márcia
Published: September 2023

Este artigo objetiva analisar a história da criação e existência do Centro Municipal de Educação Infantil (CMEI) Tio Patinhas de Mandaguari/PR, entretecida à concepção de infância e organização socioeducacional brasileira. A instituição educacional foi criada no ano de 1950, logo após a fundação do município de Mandaguari/PR e permanece até os dias atuais sendo referencial para a educação infantil na cidade. A pesquisa foi organizada com base em fontes documentais disponíveis em arquivos, bem como respostas a questionários, entremeadas a pesquisas já desenvolvidas na área. Desvelaram-se aspectos da história e memória deste CMEI em sua relação com a concepção de infância, as transformações sociais e a legislação educacional.
ENTREVISTA
Authors: Edimar de Souza José
Published: September 2023

Entrevista com o professor Óscar Saldarriaga Vélez.
La mise à l’essai du programme « T’ES prêt! » au Cégep de Jonquière : ce qu’en pensent les enseignantes en éducation spécialisée
Authors: Harvey Stéphanie , Tardif Suzie , Pouliot Eve
Published: September 2023

Pour mieux répondre aux besoins de leurs étudiants en situation de handicap, le département d’éducation spécialisée a participé à une recherche-action-formation permettant la conception et la mise à l’essai du programme « T’ES prêt ». Dans ce contexte, des entrevues qualitatives semi-dirigées ont été réalisées auprès des enseignantes (n=4) qui ont animé les activités du programme afin de connaitre leur point de vue sur ce dernier.  Les résultats montrent que les enseignantes avaient des appréhensions reliées aux exigences que demande l’implantation d’un tel programme, mais soulèvent cinq éléments qui ont facilité son déploiement.
Spatiotemporal Regulation ofDe Novoand Salvage Purine Synthesis during Brain Development
Authors: Mizukoshi Tomoya , Yamada Seiya , Sakakibara Shin-ichi
Published: September 2023

The levels of purines, essential molecules to sustain eukaryotic cell homeostasis, are regulated by the coordination of thede novoand salvage synthesis pathways. In the embryonic central nervous system (CNS), thede novopathway is considered crucial to meet the requirements for the active proliferation of neural stem/progenitor cells (NSPCs). However, how these two pathways are balanced or separately used during CNS development remains poorly understood. In this study, we showed a dynamic shift in pathway utilization, with greater reliance on thede novopathway during embryonic stages and on the salvage pathway in postnatal–adult mouse brain. The pharmacological effects of various purine synthesis inhibitorsin vitroand the expression profile of purine synthesis enzymes indicated that NSPCs in the embryonic cerebrum mainly use thede novopathway. Simultaneously, NSPCs in the cerebellum require both thede novoand the salvage pathways.In vivoadministration ofde novoinhibitors resulted in severe hypoplasia of the forebrain cortical region, indicating a gradient of purine demand along the anteroposterior axis of the embryonic brain, with cortical areas of the dorsal forebrain having higher purine requirements than ventral or posterior areas such as the striatum and thalamus. This histologic defect of the neocortex was accompanied by strong downregulation of the mechanistic target of rapamycin complex 1 (mTORC1)/ribosomal protein S6 kinase (S6K)/S6 signaling cascade, a crucial pathway for cell metabolism, growth, and survival. These findings indicate the importance of the spatiotemporal regulation of both purine pathways for mTORC1 signaling and proper brain development.
Blood-Derived Exosomes With Anti-Inflammatory Properties As A New Minimally Invasive Intratesticular Therapy For Aflatoxin B1-Associated Chronic Testopathy
Authors: Mansouri Torghabeh Fatemeh , Keivan Mona , Fakoor Mandana , Dadfar Reza , Nazarzadeh Mahsa , Abdolmaleki Amir
Published: September 2023

Rationale — Aflatoxin B1 (AB1) is a dangerous toxin causing severe poisoning and even death in human. Testopathy or even infertility is one of the adverse effects of AB1. Exosomes (Ex) with anti-inflammatory action are known as biological substances derived from body fluids. This experimental study aimed to investigate the possible therapeutic effects of blood-derived Ex on orchitis caused by chronic exposure to AB1. Methods — Male rats (n=18) were distributed among three groups: control, AB1 and AB1+Ex. Orchitis was induced with AB1 (45 μL/kg of rat weight) for 40 days (3 times a week). A day later, 10 IU Ex were injected intratesticularly. A week later, testicular tissue and blood serum were sampled. To confirm the therapeutic effects of Ex, inflammatory genes (TNF-α, IL-6 and IL-10), nitric oxide (NO), malondialdehyde (MDA), testosterone (Tes) and sperm quality were fully evaluated. In addition, H&E staining was used to investigate tissue changes, and immunohistochemical (IHC) assessment was employed to detect the inflammatory protein, galectin-3. The results were analyzed using SPSS (v.19). Results and Discussion — Our results confirmed that Ex therapy can significantly (p<0.05) increase normal morphology (25.01±2.23 in the AB1+Ex group vs. 10.1±0.9 in the AB1 group), number (76.12±6.7 in the AB1+Ex group vs. 27.8±3.2 in AB1 group), and vitality (53.4±6.12 in AB1+Ex vs. 41.9±4.6 in AB1) of sperm cells. Blood-derived Ex significantly (p<0.05) reduced the expression of inflammatory genes (6-fold change was observed in AB1+Ex vs. 17-fold in AB1 for TNF-α, 3-fold change was detected in AB1+Ex vs. 6-fold in AB1 for IL-6, and 2-fold change took place in AB1+Ex vs. 6-fold in AB1 for IL-10), NO (23.1±2.6 in AB1+Ex vs. 62.8±8 0.1 in AB1) and MDA (33.2±4.9 in AB1+Ex vs. 68.9±5.46 in AB1), and increased Tes level (7.1±0.5 in AB1+Ex vs. 1.14±0.3 in AB1) in AB1-affected rats. Histopathological evaluations revealed tissue regeneration after Ex injection. Also, the produced sperm cells were of high quality. Conclusion — Intratesticular injection of Ex from the blood can be considered as a novel anti-inflammatory therapy after AB1-induced orchitis.
Accommodation disorders in patients with visually intensive labor before LASIK in myopia (clinical cases)
Authors: Belikova Elena I. , Gatilov Denis V. , Ovechkin Igor G. , Eskina Erika N. , Yudin Vladimir Ye.
Published: September 2023

Laser keratomileusis in situ (LASIK) is the most common refractive surgery in young patients, the goal of which is to provide high distance vision without the use of glasses. One of the topical aspects of assessing the clinical effectiveness of LASIK is the dynamics of the accommodative function of the eye, which is a professionally significant function of the visual analyzer in patients with visually stressful work (VSW). Three clinical cases are presented, reflecting various states of accommodation (normal, habitual excessive tension of accommodation, asthenic form of accommodative asthenopia), diagnosed (based on the method of objective accommodation and the "quality of life" questionnaire "Computer visual syndrome — 22" in patients with VSW before LASIK. It was determined that that LASIK for various degrees of myopia in patients with VSW requires a comprehensive consideration from the standpoint of diagnosis and (or) correction of accommodative asthenopia based on a personalized approach that takes into account the main types of asthenopia. Correct diagnostics provides adequate treatment from the standpoint of choosing both the actual method (physical factor) and the required optical, amplitude and time parameters of exposure.
Phakic intraocular lens implantation in patients with stabilized keratoconus: Current state of the issue (review)
Authors: Kazantsev Anton D. , Kostenev Segrey V.
Published: September 2023

Objective: to present current data on the efficacy and safety of phakic intraocular lenses in keratoconus to correct ametropia in patients with stabilized keratoconus. Methods. The PubMed and Google Academy databases were used to search for articles. Queries were formulated taking into account the main topic of the review; the main key search phrases were: "phakic intraocular lenses", "keratoconus" in Russian and English. These keywords were used to find 72 articles. A total of 26 literature references published between 2003 and 2021 were used in this review. Conclusion. The studies presented so far indicate sufficient predictability and efficacy of the above technique. However, there are certain difficulties and possible side effects associated with this method. One of the main problems in the use of phakic intraocular lenses in patients with keratoconus is the difficulty in calculating the lens power, especially the toric component.
Influence of electronic cigarettes and tobacco heating systems on the periodontal condition in patients of different age and gender
Authors: Kishkan Alexey A.
Published: September 2023

Objective: to compare the characteristics of the periodontal condition in three categories of patients: smokers of electronic cigarettes, smokers of tobacco heating systems and non-smokers, taking into account age and gender. Material and methods. A comprehensive analysis of 1754 patient-smoker records was carried out: 1122 — electronic cigarettes (ES), 632 —tobacco heating systems (SNT). Data from 566 non-smokers were used as a control group (GC). Patients of all groups were divided into subgroups depending on age and gender. The clinical condition of the periodontium was assessed by dental indices and indicators. Statistical data analysis was performed using Microsoft Excel and Statistica 64 ver. 20.0 programs. Results. Gingivitis prevailed in the groups of persons with ES, SNT and GS. The frequency of gingivitis in the ES group decreases with age, while in the SNT group it increases. Among HS patients, gingivitis was recorded in all age groups. The frequency of acute periodontitis was highest in patients of the ES and SNT groups aged 35-39 years. In the Civil Code — at the age of 30-34 years. The frequency of gingivitis and acute periodontitis in persons of the SNT and ES group is more pronounced in women. In GS, these figures are almost equal. The frequency of registration of chronic localized periodontitis in persons of the SNT group is more pronounced in women, in the ES group these figures are higher in men. The frequency of registration of chronic general periodontitis in persons of all groups is more pronounced in women. Conclusion. The results of the study proved that the use of ES and SNT is a negative factor causing the occurrence of periodontal diseases.
Microbiological aspects of acute odontogenic osteomyelitis in children
Authors: Halyuta Elena E. , Mokhnacheva Svetlana B. , Dugina Irina G. , Kutarenko Anastasia D. , Fomina Alina A.
Published: September 2023

Objective: to determine the species composition of pathogens of acute odontogenic inflammatory processes of the jaws in children, to determine the sensitivity and resistance of the isolated microflora to antibiotics of various groups, as well as to determine the dependence of the characteristics of the clinical course of the disease on the type of dominant pathogen. Material and methods. The analysis of the results of microbiological methods for the study of exudate from purulent odontogenic foci of 900 children, due to periostitis and osteomyelitis of the jaws, was carried out. Results. In 65.6% of cases, the causative agent was Pyogenic streptococcus or group A beta-hemolytic streptococcus (BHSA) ith a high level of sensitivity to vancomycin (99%), fluoroquinolones (98%), beta-lactams (91 %) and the highest percentage of resistance to macrolides (41%). Streptococcus viridans (6.1%), Streptococcus pneumoniae (4.3%) and others were also isolated; mixed microflora (14.3%). The syndrome of endogenous intoxication of the body was manifested in 56% of cases by fever, in 38% by leukocytosis, in 57.4% by accelerated ESR. There was no statistically significant difference in the degree of endogenous intoxication in groups with different types of streptococcus. Conclusions. The cause of the inflammatory process of the jaws in 65.6% of cases was BHSA with a high level of sensitivity to vancomycin (99%), fluoroquinolones (98%), beta-lactams (91 %).
The results of surgical treatment of the ankle joint in patients with different body mass index
Authors: Wang Ruoshi , Akhtyamov Ildar F. , Ziatdinov Bulat G. , Faizrakhmanova Gulnara M.
Published: September 2023

Objective: to assess the possible effect of excess body weight on the results of surgical treatment of osteoarthritis of the ankle. Material and methods. 134 patients with moderate to advanced ankle osteoarthritis who underwent supramallear osteotomy or ankle arthrodesis. Patients were divided into 4 groups according to Body Mass Index: A) underweight (BMI≤18.5 kg / m2), B) normal weight (18.5<BMI≤25 kg / m2), C) overweight (2530 kg / m2). All patients were followed up for more than 6 months. All patients were evaluated physically, as well as by VAS (Visual Analog Scale) and AOFAS (American Orthopaedic Foot and Ankle Society). Results. The AOFAS and VAS at 3 months and 6 months after surgery were significantly better in all four groups compared to the preoperative scores. A comparison of the preoperative AOFAS and VAS scores showed no significant difference between the four groups (p=0.505, p=0.779). A comparison of the AOFAS and VAS 6 months after surgery revealed no significant difference between the four groups (p=0.313, p=0.711). Conclusions. For the middle and late stages of osteoarthritis, regardless of the level of the patient’s Body Mass Index, supramalleolar osteotomy, as well as ankle arthrodesis, showed the greatest effectiveness. During the early rehabilitation period, an increase in Body Mass Index had no negative effect on pain and functional recovery after ankle surgery.
Adaptation of the Russian version of Oxford Knee Score
Authors: Demin Alexandr S. , Sereda Andrey P. , Parfeev Dmitrii G. , Avdeev Alexandr I. , Dzhavadov Alisagib A. , Sulimov Eduard D.
Published: September 2023

Objective: to adapt the Russian version of the 1998 Oxford Knee Score (OKS) to assess the level of pain and function of the knee joint in patients both before and after primary knee arthroplasty. Material and methods. Validation and cross-cultural adaptation of the Russian version of OKS has been completed. A patient survey was conducted, and according to its results, the filling rates of both Russian-language versions of OKS were assessed, based on the criteria developed in the course of the current study. The following parameters were also evaluated in our study: validity, internal fit (Cronbach's a), reproducibility, ceiling/floor effect, filling rate, mean score, mean age of patients. Results. The study involved 200 patients hospitalized for primary knee arthroplasty. 167 of them (83%) were women, mean age 64.4 (SD 8.2) and 33 (17%) men, mean age 64 (SD 9.7). Validity index — 0.73, p<0.001, Cronbach's a — 0.864, reproducibility — 0.93 (0.76-0.98), ceiling effect in questions 1, 2, 3, 4; gender effect in questions 5, 7, 10, 11. Conclusion. The new Russian version of OKS, in comparison with the previous version, showed an improvement in the examined criteria for the comparison of the occupancy rates by 6, 9, 11 and 16%, respectively (p<0.05 for each of the criteria).
Surgical treatment of cystic vestibular schwannoma (clinical case)
Authors: Chekhonatskiy Vladimir A. , Dreval Oleg N. , Kuznetsov Aleksandr V. , Gorozhanin Aleksandr V. , Shestakov Andrei A. , Budanov Maksim M. , Sidneva Larisa A.
Published: September 2023

Objective: to demonstrate the result of successful treatment of a patient with cystic vestibular schwannoma. Currently, there is no single approach to choosing a surgical treatment method of cystic vestibular schwannoma. When choosing tactics, neurosurgeons are guided, as a rule, by the location of the tumor and the thickness of its walls. Emptying the cyst can also lead to a change in the existing relationship of the tumor with neighboring structures, especially with the facial nerve. The chosen method of treatment of this disease in the form of total removal of cystic vestibular schwannoma under the control of neurophysiological monitoring made it possible to achieve early activation of the patient and avoid postoperative complications, preserve the function the facial and trigeminal nerves involved in the tumor capsule.
Ectopic Cushing’s syndrome from a corticotropin-releasing hormone-secreting medullary thyroid carcinoma: a rare pitfall of inferior petrosal sinus sampling
Authors: Mäkinen Vivi-Nelli , Horskær Madsen Stine , Ji Riis-Vestergaard Mette , Bjerre Mette , Bønløkke Pedersen Steen , Asa Sylvia L , Rolighed Lars , Lunde Jørgensen Jens Otto , Ornstrup Marie Juul
Published: September 2023

This case report describes a rare presentation of ectopic Cushing’s syndrome (CS) due to ectopic corticotropin-releasing hormone (CRH) production from a medullary thyroid carcinoma (MTC). The patient, a 69-year-old man, presented with symptoms of muscle weakness, facial plethora, and easy bruising. An inferior petrosal sinus sampling test (IPSS) demonstrated pituitary adrenocorticotrophic hormone (ACTH) secretion, but a whole-body somatostatin receptor scintigraphy (68Ga-DOTATOC PET/CT) revealed enhanced uptake in the right thyroid lobe which, in addition to a grossly elevated serum calcitonin level, was indicative of an MTC. A 18F-DOPA PET/CT scan supported the diagnosis, and histology confirmed the presence of MTC with perinodal growth and regional lymph node metastasis. On immunohistochemical analysis, the tumor cell stained positively for calcitonin and CRH but negatively for ACTH. Distinctly elevated plasma CRH levels were documented. The patient therefore underwent thyroidectomy and bilateral adrenalectomy. This case shows that CS caused by ectopic CRH secretion may masquerade as CS due to a false positive IPSS test. It also highlights the importance of considering rare causes of CS when diagnostic test results are ambiguous.

Learning points

Medullary thyroid carcinoma may secrete CRH and cause ectopic CS.

Ectopic CRH secretion entails a rare pitfall of inferior petrosal sinus sampling yielding a false positive test.

Plasma CRH measurements can be useful in selected cases.
Criticizing “tradition” in the context of Eugen Drewermann’s “Psyhoanalytic exegesis”
Authors: Reshchikova Elizaveta
Published: September 2023

The paper examines the functions of “tradition” in the Catholic critical discourse basing on the works of one of the most provocative catholic authors of the second half of the 20th century. The meaning of “tradition” in Catholic theology seems to be rather vague; however, in the works of the 20th century theologians it is possible to trace two most general aspects of the concept: tradition as transcendent truth, given by God, and tradition as order, custom or teaching, created by people, historical in its character. The transcendent core of tradition has a strong positive connotation, while its historical aspect can be subject to critique. The two aspects are used both by the adherents of a conservative policy, and by the supporters of church reform, which testifies to a certain flexibility of the term. Eugen Drewermann, one of the most notable modern critics of the Catholic Church, uses the notion in a negative sense, which magnifies the critical potential of his argument. This critical effect does not result singularly from the definition of “tradition” Drewermann gives in his texts. In order to explicate the specific way the author uses the term and to reconstruct its critical potential, the article analyzes the notion of “tradition” functionally: basing on the author's three-volume thesis, Structures of Evil, where he combined biblical exegesis with current psychoanalytic knowledge, and Depth Psychology and Exegesis, the book where Drewermann continues to develop his innovative exegetical method. This approach makes it possible to trace how the notion acquires negative connotations: by excluding the transcendent aspect from the field of its denotations, by discussing religion in terms of psychoanalysis, as well as by linking tradition to such negatively connoted terms as “fear”, “neuroticism”, “external” and contrasting it to the “objective”, “internal”, “natural” and “true”. Eugen Drewermann’s critical interpretation of tradition based on the psychological understanding of religion in fact deprives Christianity of its transcendent origin and delegitimizes the modern institutional form of Catholicism: which allows the author to radicalize the question of the extent to which the Church is liable to change.
Letters of professor I. V. Popov from his study trip in 1901–1902 to professor S. I. Smirnov: reconstructing their academic relations
Authors: Yachmenik Vyacheslav , Kalashnikov Denis
Published: September 2023

In this publication are presented the letters written by Prof. of Moscow Theological Academy I. V. Popov. The letters of Prof. I. V. Popov, written during the period of his internship in German universities (1901–1902), and addressed to his trusted friend, Prof. of Moscow Theological Academy S. I. Smirnov. These letters are interesting in two respects: on the one hand, because they provide Popov’s impressions of his trip abroad, which throw light on his subsequent academic career, particularly in the field of organization and reform of native theological education; on the other hand, because they reveal the nature of the relationship between the two professors, and clearly show Popov’s intellectual influence on his friend and colleague Smirnov during the preparation of his future dissertation “The Spiritual Father in in the Early Eastern Church” (1906). Popov helps to Smirnov to adjust his view of the chosen research problem, which, according to his original plan, should have concerned a more comprehensive treatment of the sources, and considerably broaden the subject of his research. The published letters are held in the manuscripts department of the Russian State Library in the collection of S. I. Smirnov.
Motivation for doctors to enter the communities of sisters of mercy
Authors: Kharitonova Anastasia
Published: September 2023

The article «Motivation for doctors to enter the communities of sisters of mercy» discusses the possible reasons for the admission of doctors to the communities of sisters of mercy that have been operating on the territory of the Russian Empire since the middle of the 19th century. The communities were unique private charitable organizations that had as their goal the training of new female medical personnel. The reasons are identified by studying the conditions of service of doctors in the communities, which are reflected in the regulatory and office documents. This is material support, social benefits provided to doctors, awards, material for conducting medical practice and medical research. The reasons recorded in some sources of personal origin are also called. The article takes into account the historical context of the existence of doctors. Namely, the statements of representatives of the medical staff of the late XIX - early XX centuries about their financial situation, which had a negative connotation, and their assessment of the quality of training of medical personnel at the medical faculties of Russian universities. The study draws attention to the staff of doctors, their age, experience. The determined motives for entering the communities are correlated with the categories (identified by age, professional level, social status) of doctors. The result of the study is the following statements. Young doctors of the community were given the opportunity to get a job in the capital and a good medical practice. For older and more experienced doctors, the motives for getting a job in these communities were the rights of the civil service. They might also have been attracted to the idea of philanthropy from the communities of sisters of mercy and the communication and cooperation with influential representatives of high society. In addition, the research work developed in the communities attracted doctors of different ages and levels of professionalism.
Professors of Church law at Russian universities and theological academies in 1906‒1917
Authors: Iliukhina Olga
Published: September 2023

The article examines the scientific potential of higher schools of the Russian Empire, universities and theological academies, in the field of ecclesiastical law during the active discussion of church reforms in 1906-1917. The author comes to the conclusion that at the beginning of the XX century it is necessary to talk about three developed scientific schools of ecclesiastical law: the St. Petersburg University school of M.I. Gorchakov, associated with it the Moscow University school of N.S. Suvorov and the Kazan School of I.S. Berdnikov. At the same time, only the latter one can be described as having preserved a close connection between the academy and the university. Universities were aimed at replacing the staff of the departments of ecclesiastical law with their graduates. In St. Petersburg and Moscow, it was possible to do this at the beginning of the XX century: V.N. Beneshevich and P.V. Gidulyanov, university graduates, became professors of the Department of Ecclesiastical Law. And the statistics of doctoral dissertations reveal the special role of Moscow University in the training of secular specialists in ecclesiastical law and shows that university scientific schools should be recognized as dominant in science. Strict administrative control and frequent changes of professorial staff at the departments of ecclesiastical law in the St. Petersburg and Moscow Theological Academies in the examined period obviously hindered the development of their own stable scientific traditions. Some stagnation is also noticeable in the Kiev Academy, where M.I. Mishchenko, the Master of Theology, was permanently at the similar department during this period. The inclusion of ecclesiastical law in the list of legal sciences has significantly expanded the scope of research: in addition to the actual study of history or the interpretation of the canons, church-state relations, problems of freedom of conscience, the relationship of the church court and state jurisdiction, as well as civil and family law began to be studied. Scientific achievements turned out to be relevant in the preparation of church reform in pre-Council forums, where university professors were invited mainly.