bluuebunny/crossref_metadata_2025 huggingface dataset:
Nociception Effect on Frontal Electroencephalogram Waveform and Phase-Amplitude Coupling in Laparoscopic Surgery
Authors: Wang Tzu Chun , Li Wei Yi , Lai Jerry Cheng-Yen , Kuo Terry B. J. , Yang Cheryl C. H.
Published: July 2023

BACKGROUND:

Electroencephalographic pattern changes during anesthesia reflect the nociception-analgesia balance. Alpha dropout, delta arousal, and beta arousal with noxious stimulation have been described during anesthesia; however, data on the reaction of other electroencephalogram signatures toward nociception are scarce. Analyzing the effects of nociception on different electroencephalogram signatures may help us find new nociception markers in anesthesia and understand the neurophysiology of pain in the brain. This study aimed to analyze the electroencephalographic frequency pattern and phase-amplitude coupling change during laparoscopic surgeries.

METHODS:

This study evaluated 34 patients who underwent laparoscopic surgery. The electroencephalogram frequency band power and phase-amplitude coupling of different frequencies were analyzed across 3 stages of laparoscopy: incision, insufflation, and opioid stages. Repeated-measures analysis of variance with a mixed model and the Bonferroni method for multiple comparisons were used to analyze the changes in the electroencephalogram signatures between the preincision and postincision/postinsufflation/postopioid phases.

RESULTS:

During noxious stimulation, the frequency spectrum showed obvious decreases in the alpha power percentage after the incision (mean ± standard error of the mean [SEM], 26.27 ± 0.44 and 24.37 ± 0.66; P < .001) and insufflation stages (26.27 ± 0.44 and 24.40 ± 0.68; P = .002), which recovered after opioid administration. Further phase-amplitude analyses showed that the modulation index (MI) of the delta-alpha coupling decreased after the incision stage (1.83 ± 0.22 and 0.98 ± 0.14 [MI × 103]; P < .001), continued to be suppressed during the insufflation stage (1.83 ± 0.22 and 1.17 ± 0.15 [MI × 103]; P = .044), and recovered after opioid administration.

CONCLUSIONS:

Alpha dropout during noxious stimulation is observed in laparoscopic surgeries under sevoflurane. In addition, the modulation index of delta-alpha coupling decreases during noxious stimulation and recovers after the administration of rescue opioids. Phase-amplitude coupling of the electroencephalogram may be a new approach for evaluating the nociception-analgesia balance during anesthesia.
Secondary traumatic stress and death anxiety in healthcare professionals: Moderating role of social support
Authors: Qayyum Shazia , Tahir Ayesha , Younas Faiz
Published: July 2023

Background & Objective: It’s hard to deny the buffering impact of social support as it provides much-needed assistance to counter untoward circumstances that individuals face in their daily life. By focusing on the moderating role of social support, the present investigation studied the relationship between secondary traumatic stress and death anxiety that healthcare professionals encounter in their regular work life.

Method: Through a cross-sectional correlational design, 200 participants were included from various hospitals in Lahore (from June-August, 2022) by employing a non-probability purposive sampling technique. They provided basic sociodemographic information along with their responses on self-reported questionnaires for the current investigation.

Results: Results were analyzed through SPSS 21 which indicated that secondary traumatic stress had a positive association with death anxiety, unlike social support which had a negative relationship with death anxiety. Findings also revealed social support as a significant moderator for secondary traumatic stress and death anxiety.

Conclusions: It can be concluded that increased social support could benefit healthcare professionals as it weakened the association between secondary traumatic stress and death anxiety. Other than academia and research, these findings have implications across a variety of professional settings including physical and mental healthcare professionals who can benefit from these indigenous findings.

doi: https://doi.org/10.12669/pjms.39.5.7254

How to cite this: Qayyum S, Tahir A, Younas F. Secondary traumatic stress and death anxiety in healthcare professionals: Moderating role of social support. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7254

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reimaging study in the management of blunt abdominal trauma in children: a low income country single center experience
Authors: Ben Youssef Sabrine , Mesaoud Marwa , Ben fredj Myriam , Boukhrissa Nouha , Abdelaaly Mabrouk , ben Mansour Maha , Mosbahi Sana , Sfar Sami , Chakroun Sawsen , Ksia Amine , Sahnoun Lassaad , Mekki Mongi , Zrig Ahmed , Belghith Mohsen
Published: July 2023

Introduction: The abdomen is the most prevalent site of primarily unidentified fatal injury after blunt trauma, and represents the third major affected part. However, follow-up strategies of intra-abdominal injuries remain controversial. The aim of this study is to describe the characteristics of children with blunt abdominal trauma (BAT) and who presented radiographic amendments in re-imaging studies and predict factors that could identify patients group requiring control in this population.  

Methods: A retrospective study was conducted in the department of pediatric surgery and the intensive care unit of Monastir involving all patients under the age of 14 years old who were admitted for blunt abdominal trauma between January 2010 and December 2021.An analysis of epidemiological, clinical, radiological and therapeutic management characteristics were performed.

Results: A total of 151 patients were included in this study with a mean age of six years. The sex ratio (m/f) was 2.7. Most trauma circumstances were related to road accidents (43.7%) and falls (32.4%). The liver, the spleen, and the kidneys were the most frequently affected organs. A combination of intra-abdominal lesions was recorded in 32 cases. 84% of the cases (110/131) of the reimaged patients had no complications, compared to 16% (21/131) who developed intra-abdominal complications. The complicated reimaging findings were significantly associated with high grade hepatic and renal injuries (p=0.019 and 0.002, respectively), and patient symptom persistence or development (p=0.001).

Conclusion: It is safe to avoid performing reimaging studies if clinical progression remains uneventful in children with low-grade hepatic, splenic, and renal lesions. However, the clinical assessment is the most crucial consideration during BAT management in children.
Symptoms trend and challenges in dental practice during delta variance COVID-19 pandemic in Indonesia: Google Trends Analysis
Authors: Hasan Faizul , Mayasari Noor Rohmah , Salamanca Eisner , Dorj Odontuya , Satria Rahmat Dani , Latief Kamaluddin , Sujarwadi Mokh. , Budi Hendrik Setia
Published: July 2023

Background: The COVID-19 pandemic has grown to be a serious issue on a global scale. Dental care is one of the industries affected by COVID-19. The surveillance utilizing lifetime data, however, is still not clear. The purpose of this study was to use Google Trends (GT) analysis to examine symptom trends and challenges during the COVID-19 outbreak in Indonesia.

Methods: Covid-19 cases retrieve from Our World in Data. The cases were collected between 1 April 2021-30 September 2021. The GT was used to discover Indonesian relative search volume (RSVs) covering the timeframe of the first outbreak covid-19 pandemic in Indonesia on 1 March 2020 until 13 February 2022. The duration of the search was chosen to reflect the relative popularity of the keywords "symptoms and dentistry practice challenge-related terms" and "coronavirus". Results: We observed that there was a significant and positive correlation between the COVID-19 daily case using GT RSV data and the COVID-19 case from Our World in Data. The COVID-19 daily case had a strong correlation with search terms related to symptoms (such as fever, sore throat, flu, toothache, and cough), drugs (such as ibuprofen, paracetamol, demacolin, bodrex, and antibiotic), and health management (such as self-isolation and telemedicine).

Conclusion: Using GT may be helpful to observe the current symptoms trends as well as its challenge tendencies as a surveillance tool for a continuing pandemic like COVID-19. GT should be considered and used as it has the potential to be a powerful digital epidemiology tool that can provide more insight into disease dynamics.
Association between physical activity and mental wellbeing amongst adults in the urban area of the Wardha District – A study protocol
Authors: Shukla Apoorva , Choudhari Sonali
Published: July 2023

Introduction: Severe mental illness is a pressing social issue that needs to be immediately addressed in India and globally. Unfortunately, the mental health of many adults in India and other countries has been declining. Fortunately, physical activity has proven to be an effective way to address this issue and provides many beneficial effects. Thus, mental wellbeing stipulates how the person feels when all the associated elements are considered.

Objectives: The objective of this study is to determine the relationship between physical activity and adult mental health.

Methods: This study will be conducted online using cross-sectional methods. Data will be collected using four validated questionnaires, the Short‑form International Physical Activity Questionnaire (IPAQ) version 2.0, the Warwick‑Edinburg Mental Wellbeing Scale (WEMWBS), the Pemberton Happiness Index (PHI), and the Patient Health Questionnaire (PHQ-9), all in English.

Study implications: The motive of this study is to explore any connections that might lie between physical activity and emotional health. The study will specifically focus on the intensity by which physical activity is done, ranging from lower to higher, and how it affects mental illness symptoms and general mental health.
Measurement properties of physical activity in adults with bronchiectasis: A systematic review protocol
Authors: Bhat Anup , Lee Annemarie L , Maiya G Arun , Vaishali K.
Published: July 2023

Abstract: People with bronchiectasis reduce their physical activity (PA) due to muscle weakness, dyspnea, fatigue, reduced exercise capacity and frequent cough with expectoration. Patient-reported and objective physical assessment methods have been used to evaluate PA in people with bronchiectasis. In the literature, significant differences in the PA measured using patient-reported outcome measures when compared with the objective methods. Given the availability of many PA assessment tools, it is tedious for the clinician or researcher to choose an outcome measure for clinical practice or research. The evidence on validity and reliability in bronchiectasis are unclear.

Objectives: To identify the PA assessment tools, describe and evaluate the literature on psychometric properties of instruments measuring and analyzing PA.

Methods: The search will be conducted in PubMed/Medline, Cochrane Central Register of Controlled Studies, Scopus and EMBASE databases. The keywords, index terms and synonyms of the following words will be used: bronchiectasis, physical activity, and outcome measures. Published studies of adult with clinical and/ or radiologically diagnosed bronchiectasis, aged >18 years, any gender and studies that assessed PA and/or if there are reports on measurement properties of PA will be included in the review. Studies using qualitative research methods, narrative reviews, letters to editors and editorials will be excluded. The quality of the study will be assessed and data will be extracted. Any disagreement will be resolved in the presence of an author not involved in the screening or selecting studies.

Discussion: By assessing the quality of studies on measurement properties, this review will help researchers choose the outcome measure to evaluate the effects of interventions on PA. This review will identify the suite of outcome measures of PA for people with bronchiectasis that can be used for research and clinical purpose.
Stereotactic radiotherapy for ventricular tachycardia: A study protocol
Authors: Kawamura Mariko , Shimojo Masafumi , Inden Yasuya , Kamomae Takeshi , Okudaira Kuniyasu , Komada Tomohiro , Aoki Sumire , Shindo Yurika , Yasui Ryotaro , Yanagi Yusuke , Okumura Masayuki , Yamada Takehiro , Kozai Yuka , Oie Yumi , Kato Yutaka , Ishihara Shunichi , Murohara Toyoaki , Naganawa Shinji
Published: July 2023

Background: Currently, the standard curative treatment for ventricular tachycardia (VT) and ventricular fibrillation (VF) is radiofrequency catheter ablation. However, when the VT circuit is deep in the myocardium, the catheter may not be delivered, and a new, minimally invasive treatment using different energies is desired.

Methods: This is a protocol paper for a feasibility study designed to provide stereotactic radiotherapy for refractory VT not cured by catheter ablation after at least one catheter ablation. The primary end point is to evaluate the short-term safety of this treatment and the secondary endpoint is to evaluate its efficacy as assessed by the reduction in VT episode. Cyberknife M6 radiosurgery system will be used for treatment, and the prescribed dose to the target will be 25Gy in one fraction. The study will be conducted on three patients.

Conclusion: Since catheter ablation is the only treatment option for VT that is covered by insurance in Japan, there is currently no other treatment for VT/VF that cannot be cured by catheter ablation. We hope that this feasibility study will provide hope for patients who are currently under the stress of ICD activation.

Trial registration: The study has been registered in the Japan Registry of Clinical Trials (jRCTs042230030).
SOME ISSUES OF ORGANIZATIONAL AND LEGAL REGULATION OF THE DIGITALIZATION OF AGRICULTURE
Authors: Ibragimov Kyuri , Ibragimov Alkhazur , Ibragimov Dzhammirz
Published: July 2023

The study was carried out in order to study organizational and legal measures to mitigate the negative consequences of the digitalization of agriculture. The developed countries of the world, which initially had a high level of development of the agricultural sector, a wide network of highly professional agricultural research and educational institutions, respectively, qualified scientific personnel - agrarians, a steadily functioning system of agrarian law and many other advantages, have shown today a good susceptibility to the digital transformation of agriculture , and here the horizons of a new competitive digital agricultural economy have already been clearly outlined. At the same time, it should be recognized that, due to the innovative nature of this phenomenon, in Russia there is an extremely narrow list of scientific works devoted to the digital transformation of agriculture, and organizational and legal issues in this area have been practically considered little, and then, from the standpoint of the interests of an individual agricultural enterprise or farming. This predetermined the relevance of the study. Digital technologies, having solved the most important problem of the agricultural producer - the sale of products - helped to focus his main attention on increasing the production of his own products while reducing its cost and improving quality. It will be very difficult for most agricultural producers in Russia to navigate the innovations of digitalization of their production without the development of an appropriate digital agricultural law. However, even in the presence of the latter, the solution to this problem will be possible only with the resuscitation by the state in each rural region of the country of the information and advisory service, which needs to be reactivated from the standpoint of the needs of the digitalization of the agricultural industry and with the development of appropriate measures to stimulate the positive work of its consultants. Moreover, it seems that the digital retraining of farmers should also undoubtedly be undertaken by the state, as well as the prevention of a digital divide between economic entities that benefit from the use of agricultural products in the form of food or raw materials.
DETERMINATION OF BIFURCATION POINTS IN THE FUNCTIONING OF “SOIL-PLANT–AIR” SYSTEM
Authors: Maksimov Ivan , Kalimullin Marat , Alekseev Evgeniy , Vasiliev Aleksey , Maksimov Nikita
Published: July 2023

To date, a number of mathematical models of plant growth, developed by domestic and foreign scientists, are known. However, the issues of determining the bifurcation points that arise during the functioning of “soil-plant-air” system have not been sufficiently considered. In relation to the issues considered in the article, the bifurcation point is a critical state of the “plant” subsystem, at which it becomes unstable with respect to fluctuations in natural and climatic conditions (drought, frost, prolonged rains, etc.) and there is uncertainty in the development of plants (further growth or their death), as well as the intensive growth of plants as a result of the corresponding technological operations. For control and operational management of the formation of agricultural crops, it is desirable to know the bifurcation points determined by the biological time of plant growth and extreme weather situations. Therefore, the main goal of research is the analytical determination of bifurcation points observed during the vegetation of plants. The “plant” subsystem at the bifurcation point can be simultaneously in two or more states. As a result of the analysis of the obtained analytical dependences of various possible states of “soil-plant-air” system, it is proposed to subdivide bifurcations into negative and positive ones. A method has been obtained for determining bifurcation points during the functioning of “soil-plant-air” system. Under natural and climatic conditions, critical situations can arise with insufficient incoming substances to “soil-plant-air” system, such as light supply, moisture supply, heat supply, food supply and gas supply of plants. As a result of analytical studies, bifurcation points were determined in “soil-plant-air” system, depending on the radiation balance (R) formed on the underlying surface, slopes of different exposure and steepness, and coefficients characterizing light, moisture, heat, food and gas supply plants.
Thickness Wall for Synthetic Material
Authors: Knight Helen
Published: July 2023

Researchers find clothing could benefit from new stretching properties
Floating Deep Farms Promise Year-Round Crops
Authors: Knight Helen
Published: July 2023

Containers could grow crops and act as a sink for carbon dioxide
Antibacterial Activity of Durian Peel Ethanol Extract (Durio zibethinus Murr.) against Streptococcus mutans and Enterococcus faecalis
Authors: Octiara Essie , Meliala Chintya Pricilia , Sikumbang Lisdayanti
Published: July 2023

Dental caries and root canal infections are common dental and oral diseases due to the dominance of S.mutans and E.faecalis. Despite not having any economic value and becoming a waste, durian peel is claimed as an antibacterial. This study aims to analyze durian peel ethanol extract antibacterial activity against S.mutans and E.faecalis based on the inhibition zone diameter, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). This type of research is a laboratory experiment using Post-test Only Control Group Design. There were 7 concentrations of durian peel ethanol extract (50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, and 0.78%), both positive and negative control with three times repetitions. Moreover, the bacterial suspensions used were S.mutans ATCC 25175 and E.faecalis ATCC 29212. Data analysis used One Way Anova, while data that were not normally distributed used Kruskal-Wallis. Post Hoc analysis used LSD for normal data and Mann-Whitney for abnormal data. Durian peel ethanol extract shows the antibacterial activity of S.mutans with MIC at a concentration of 0.78%, while against E.faecalis is 12.5%. The higher the concentration, the larger the inhibition zone formed. The best-tested concentration of ethanol extract from durian peel is 6.25-50% to inhibit the growth of S. mutans and 50% for E.faecalis. Durian peel ethanol extract can prevent dental caries since it is antibacterial against S.mutans and E.faecalis.
Association between hyperlipidemia and trigger finger: A nationwide population-based cohort study
Authors: Chen Pei-Tsen , Zhang Han-Wei , Tsai Zhi-Ren , Peng Hsiao-Ching , Lin Yu-Shan , Tsai Jeffrey J. P. , Lin Chao-Wen
Published: July 2023

The cause of trigger fingers remains uncertain. High lipid levels in the blood may reduce blood supply to the distal fingers and promote inflammation. We aimed to explore the association between hyperlipidemia and trigger finger. A nationwide population-based cohort study using longitudinal data from 2000 to 2013, 41,421 patients were included in the hyperlipidemia cohort and 82,842 age- and sex-matched patients were included in the control cohort. The mean age was 49.90 ± 14.73 years in the hyperlipidemia cohort and 49.79 ± 14.71 years in the control cohort. After adjusting for possible comorbidities, the hazard ratio of trigger finger in the hyperlipidemia cohort was 4.03 (95% confidence interval [CI], 3.57–4.55), with values of 4.59 (95% CI, 3.67–5.73) and 3.77 (95% CI, 3.26–4.36) among male and female patients, respectively. This large-scale population-based study demonstrated that hyperlipidemia is correlated to trigger finger.
Gaio Suetónio Tranquilo, Vidas dos Césares. Livro VII. Galba, Otão e Vitélio
Authors: Brandão José Luís
Published: July 2023

O volume contém a tradução, acompanhada de introdução e notas, das Vidas dos três breves imperadores – Galba, Otão e Vitélio – que se sucederam em Roma entre a morte de Nero em junho de 68 d.C. e a entrada violenta dos partidários de Vespasiano na Urbe, em dezembro de 69. Trata-se, pois, das biografias dos protagonistas de uma época sangrenta de transição dinástica entre os imperadores júlio-Cláudios, que se extinguiram com Nero, e os Flávios, dinastia inaugurada por Vespasiano: um período de 18 meses de convulsão em que a investidura imperial é, por assim dizer, descentralizada, e exércitos provinciais e soldados pretorianos rivalizam entre si na mira de impor um imperador do seu agrado.
Elevações na frequência de ocorrência de secas meteorológicas no Estado de São Paulo sob condições de mudanças climáticas
Authors: Constantino Blain Gabriel , Da Rocha Sobierajski Graciela , Lopes Martins Letícia
Published: July 2023

Elevações na frequência e intensidade da seca vêm sendo observadas em diversas regiões do planeta, sendo que as mudanças climáticas são frequentemente apontadas como uma das principais responsáveis por essas alterações. Considerando os severos impactos causados por essa adversidade ambiental, o objetivo desse estudo é detectar e quantificar possíveis alterações na probabilidade de ocorrência dos eventos de seca meteorológica no Estado de São Paulo. Foram utilizados dados de precipitação pluvial do projeto NASA-POWER, o qual é capaz de fornecer séries com mais de 30 anos. Os eventos de seca foram quantificados com base no Índice Padronizado de Precipitação (SPI), calculado por meio de método probabilístico não estacionário (“the four-step algorithm”), especialmente desenvolvido para aprimorar a interpretação do SPI sob condições de mudanças climáticas. Os resultados apontaram elevações na frequência da seca meteorológica com picos máximos em meses de transição entre as estações chuvosa e seca, como março e abril. Os meses de dezembro e janeiro (auge do período chuvoso) também apresentaram elevações na ocorrência dessa adversidade ambiental, com predomínio nas porções leste de São Paulo, incluindo o Sistema Cantareira. Sob o ponto de vista de gestão de recursos agroambientais, conclui-se que há aumento no risco climático associado à ocorrência da seca no estado de São Paulo. Sob o ponto de vista acadêmico, esse trabalho amplia o rol de evidências que suportam a hipótese de que as mudanças climáticas estejam afetando a frequência e a severidade dos déficits de precipitação em diversas partes do planeta.
Mushroom Sign: Complete Esophageal Obstruction After Esophageal Variceal Band Ligation With Successful Removal of Variceal Band
Authors: Gandhi Mustafa , Chela Harleen Kaur , Daglilar Ebubekir , Hammoud Ghassan
Published: July 2023

Esophageal varices due to portal hypertension are treated with endoscopic variceal band ligation (EVBL), a minimally invasive procedure with potential complications, such as pain, bleeding, and stricture formation. Rarely, complete esophageal obstruction can occur secondary to edema of the mucosa. Most cases can be managed conservatively, but intervention is necessary for severe symptoms with a risk for aspiration and airway compromise. Since EVBL is such a common procedure, it is important for clinicians to be aware of this rare but severe complication. An 80-year-old woman presented with severe dysphagia and chest discomfort after a recent EVBL. Esophagogastroduodenoscopy revealed esophageal mucosal edema and complete obstruction of the esophageal lumen. The band was removed with a loop cutter with subsequent balloon dilation to relieve the obstruction.
Experience of successful laparoscopic sleeve resection of the stomach and treatment of morbid obesity in a patient with a classic form of congenital adrenal dysfunction
Authors: Zatsepina E. A. , Samoilov V. S. , Volynkina A. P. , Stepanenko A. V. , Novichikhina E. E.
Published: July 2023

The article presents a clinical observation of a patient with congenital adrenal dysfunction (CHD), a salt-losing form of 21-hydroxylase enzyme deficiency (homozygous mutation I 172N), and also with morbid obesity, due to long-term use of high doses of glucocorticosteroids, who underwent bariatric surgery — laparoscopic sleeve resection of the stomach. A feature of the presented case is the elimination of one of the causes of decompensation of the disease, namely, overweight, as well as insulin resistance, which requires the intake of large doses of glucocorticoids, which in turn leads to a worsening of the course of obesity, thereby causing a vicious circle. 7 months after surgical treatment, the goal was achieved — a reduction in the dose of Prednisolone by 25%, with a decrease in body weight by 72.1% of overweight.

The presented case clearly demonstrates the possibility of performing bariatric surgery for the treatment of morbid obesity in patients with CAH with the participation and control of a specialized multidisciplinary team. If there are indications for bariatric intervention, VDKN should not be an absolute contraindication to such operations, and the ratio of the safety profile and the efficacy profile testifies in favor of the need for their implementation.
The features of regulatory T-blood cells subpopulation and the level of CD25 expression in patients with Graves’ disease in dynamics after radioactive iodine therapy
Authors: Dudina M. A. , Savchenko A. A. , Dogadin S. A. , Borisov A. G. , Belenyuk V. D.
Published: July 2023

BACKGROUND: The content of regulatory T cells (Treg) at different stages in formation of effector subpopulations and the level of CD25 expression on the membrane of their various fractions in Graves’ disease can determine the long-term autoimmune process persistence and be the target of immunotropic therapy of the disease.

AIM: To study the features of regulatory T-blood cells subpopulation and the level of CD25 expression in patients with Graves’ disease in dynamics after radioactive iodine therapy (RIT) to identify the specific Treg subpopulations for potential immunotropic therapy targets of the disease.

MATERIALS AND METHODS: A single-center, prospective, cohort, open, controlled study was conducted with the participation of women with laboratory-confirmed Graves’ disease. The features of regulatory T-blood cells subpopulation and the level of expression (MFI) CD25 surface receptor were studied by flow cytometry using direct immunofluorescence using monoclonal antibodies.

RESULTS: The study included 36 women with recurrent Graves’ disease, middle age 46.34±14.32 years. In patients with Graves’ disease before and during the entire period after RIT a low percentage of naive (CD45R0-CD62L+) and terminally differentiated (CD45R0-CD62L-) Treg was established relative to the control, and on 3 and 6 months after RIT a significant decrease of cells with this phenotype was revealed relative to the values detected in patients before and 1 month after RIT (p<0.001). Against the background of compensated hypothyroidism the most significant changes of expression CD25 receptor in patients with Graves’ disease were found on 3 and 6 months after RIT: reduced levels of MFI CD25 on surface of naive and terminally differentiated Treg.

CONCLUSION: A decrease in the level of naive Treg was found (apparently due to a violation of differentiation processes in thymus) and terminally differentiated Tregs (due to maturation and survival processes), which are supplemented by a reduced expression of the CD25 receptor on the surface of these cells and do not depend on hyperthyroidism compensation, the titer of TSH receptor antibodies, previous conservative therapy with thiamazole and RIT. The obtained new data reveal the role of naive and terminally differentiated Treg subpopulations in immunopathogenesis and help to outline further ways to develop approaches for immunotropic therapy.
Features of aging replicative and biochemical aspects among females with non-iatrogenic hypergonadotropic hypogonadism
Authors: Mikheev R. K. , Andreeva E. N. , Grigoryan O. R. , Sheremetyeva E. V. , Absatarova Yu. S. , Volevodz N. N. , Loginova E. V.
Published: July 2023

BACKGROUND: Estrogenic deficiency is the basic condition of human ageing that leads to hypergonadotropic hypogonadism. The existence of correlation between hypergonadotropic hypogonadism, replicative (leukocyte telomere length) and biochemical data is widely supposed among females with physiological (menopausal) and pathological (primary ovarian insufficiency) estrogenic deficiency is not unreasonable.

AIM: To evaluate features of replicative (telomere length) and biochemical (metabolic syndrome) ageing markers among females with physiological (menopausal) and pathological (primary ovarian insufficiency) estrogenic deficiency.

MATERIALS AND METHODS: Research has been provided in collaboration between Endocrinology Research Centre of the Russian Ministry of Health and Lomonosov Moscow State University Medical Research and Educational Centre in the period since 10.01.2021 until 01.08.2022.

110 females (20-75y.o.) have participated in the present research.

Group 1: 26 females receiving menopausal hormonal therapy (MHT) ≥ 5 years with 0,5; 1; 2 mg estrogenic component.

Group 2: 27 females in physiological menopause without MHT

Group 3: 33 females with primary ovarian insufficiency and receiving sex-steroid replacement therapy.

Group 4: 24 healthy reproductive age females without sex-steroid replacement therapy.

Patients have undergone laboratory genetic (leucocyte telomere length), biochemical analyses.

DNA extraction — with Qiagen DNA blood mini kit (Germany). Biological material was cito conserved with Ficoll solution. Leukocyte telomere length — with real-time polymerase chain reaction PCR (Flow-fish).

Soft program IBM SPSS Statistics (version 26,0 for Windows) has been used for statical analysis.

RESULTS.

1.Menopausal females receiving MHT were inclined to highest HDL-P levels (p<0,006).

2.Females with primary ovarian insufficiency were inclined to relatively highest serum creatinine level (p<0,001).

3.Reproductive age females had relatively highest telomere length (p<0,001).

4.FSH level correlates negatively and moderately (ρ= - 0,434) leukocyte telomere length (р<0,001) among females.

CONCLUSION: Females with premature ovarian insufficiency are most sensible to ageing due to features of replicative and biochemical markers.
Educational trajectories of the endocrinological service: the results of a survey
Authors: Pigarova E. A. , Vorotnikova S. Yu. , Belotserkovskaya T. B.
Published: July 2023

Given the socio-economic, political and epidemiological changes in the regions of the Russian Federation, the issue of modernizing the training of medical personnel and planning to provide medical organizations with qualified specialists has remained extremely important for several years. The analysis of the survey showed that at present the highly topical issue of staffing the population with endocrinologists and pediatric endocrinologists does not have an unambiguous effective solution. The above measures to reorganize the educational environment require additional revision and correction for the most effective work in the field of medical education. Ultimately, these activities will have an impact on improving the level of training of specialists, improving the personnel situation in the constituent entities of the Russian Federation and improving the quality of medical care for the population of the country.
Perceived job insecurity and sickness presenteeism among public service employees: Moderated mediation model of organisational culture and gender
Authors: Akanni Abimbola A. , Oduaran Choja A. , Ekundayo Opeyemi O.
Published: July 2023

Previous research efforts have concentrated on the link between personal factors and sickness presenteeism, with few attempts to research the roles of contextual factors such as organisational culture and perceived job insecurity. Also, the mechanism through which the link exists has not been examined across the gender divide. Therefore, this paper examined the moderated mediation effects of gender on the relationship between perceived job insecurity and sickness presenteeism through organisational culture. A total of 244 (F=140; M=104) respondents participated in the study. The Stanford Presenteeism Scale and Job Insecurity and Organisational Culture scales were used for data collection. Results of the correlation analysis revealed that perceived job insecurity is negatively associated with organisational culture and sickness presenteeism. It also revealed that organisational culture is positively related to sickness presenteeism. The Hayes PROCESS macro analysis showed that organisational culture mediated the relationship between perceived job insecurity and sickness presenteeism. Furthermore, the results of the moderated mediation analysis showed that gender moderated the mediating role of organisational culture in the relationship between perceived job insecurity and sickness presenteeism. The study concluded that the indirect effect of perceived job insecurity on sickness presenteeism through organisational culture was higher among female respondents than their male counterparts.
UNDERSTANDING THE IMPACT OF TALENT AND COMPETENCE MANAGEMENT ON EMPLOYEE PERFORMANCE THROUGH ORGANIZATIONAL COMMITMENT
Authors: Haryanti Nik , Imam Junaris  , Winarto
Published: July 2023

This study aims to obtain empirical evidence and develop a theory (predictive orientation) of the effect of talent management and competence on performance mediated by organizational commitment at Madrasa Aliyah (MA) Ma'arif Udanawu Blitar. The research approach uses an explanative survey approach. The questionnaire was prepared based on talent management, competence, performance, and organizational commitment. The research data was taken from 30 respondents. Data collection was carried out by using a random sampling technique. In this study, data analysis used the Partial Least Square (PLS) approach using Smart PLS software. PLS is a component or (variance) based structural equation model (SEM). The study shows that talent and competency management affect a person's performance. The better the management of talent and competency, the better the performance will be. When the performance improves, the higher the organizational commitment you have. In addition, the better one's talent management, the higher the organizational commitment.
Reflexiones en torno a la construcción teórica de la categoría afectividad
Authors: Varona Domínguez Freddy
Published: July 2023

El centro de atención de este ensayo es la construcción teórica de la categoría afectividad, la cual se concibe como un sistema formado por las emociones, los sentimientos y las pasiones, de los cuales también se despliegan reflexiones en torno a su elaboración teórica. Este estudio se despliega desde una perspectiva filosófica y con una mirada totalizadora. Forman parte del contenido algunas elaboraciones teóricas de autores imprescindibles para entender estas temáticas y polemizar en torno a ellas, entre los cuales están Juan Luis Vives, Renato Descartes, David Hume (a quien se le brinda una atención más esmerada) y Adam Smith; no obstante, también forman parte del contenido criterios de algunos estudiosos contemporáneos, como el filósofo italiano Remo Bodei y el filósofo español José Antonio Marina. Al profundizar en las categorías referidas, se establecen relaciones con facultades humanas, como la imaginación, así como con los valores, la cultura y el mejoramiento humano.
Creencias e imaginaciones: reexaminando el problema tipológico de los delirios
Authors: López-Silva Pablo
Published: July 2023

El problema tipológico surge al intentar definir el tipo de estado mental que subyace a los reportes de pacientes delirantes. Este artículo explora dos de los enfoques más populares a este problema en la literatura actual en filosofía de la mente. El análisis concluye que el enfoque doxástico —que conceptualiza los delirios como creencias anormales— es superior en términos conceptuales, empíricos y fenomenológicos al enfoque imaginístico, que caracteriza a los delirios como un tipo de estado mental imaginario. Finalmente, se concluye con algunos de los desafíos que el enfoque necesita resolver para ampliar su alcance y poder explicativo.
The Effect of Social Support on Stress Levels of Health Workers During The COVID-19 Pandemic: A Literature Review
Authors: Rachmayanti Riris Diana , Bawazier Kamila Fihir , Yasutome Takako , Indawati Rachmah , Riswari Aninditya Ardhana , Ismayani Ismayani , Ramani Andrei , Yulianti Anysiah Elly , Sari Jayanti Dian Eka
Published: July 2023

Background: The COVID-19 pandemic has caused various changes in the social dynamics of life. Almost all age groups in various countries are forced to adopt new habits that have the potential to interfere with mental health. Providing social support can be useful for reducing the stress level of health workers. Proper social support can overcome stress problems. The purpose of this study was to analyze the effect of social support on the stress level of health workers during the COVID-19 pandemic.Method: This is a literature review using population, intervention, comparison, results, research design, and keywords used according to the research topic. Keyword use Mesh term strategy with the term "social support" stress" "worker" "pandemic" and "COVID". Database sources are ScienceDirect, PubMed, Google Scholar, and SAGE. Searching strategy uses Prisma guidelines. The total article was 2,226 and the eligible article was 24 articles. The collected data were analyzed through a thematic review. The data analysis technique in this study was descriptive analysis.Results: The results of the study show that most health workers experience moderate levels of stress during the pandemic. The most influential sources of social support come from colleagues and partners. The form of social support that is often received and influences stress levels is emotional support. There is an effective effect of social support on the stress level of health workers during the pandemic. Therefore, it can be concluded that adaptation during COVID-19 has caused various changes in conditions and pressure for health workers
Biopsychosocial Factors Affecting the Quality of Life of Hemodialysis Patients
Authors: Anggraini Merry Tiyas , Gunadi Gunadi
Published: July 2023

Background: Hemodialysis is performed to support the life of Chronic Kidney Disease patients. However, it affects the patient's quality of life in some cases. Clinical factors get enough attention in daily medical practice, while patients' psychological and social aspects are often ignored. This study aims to analyze the biopsychosocial factors affecting hemodialysis patients' quality of life at Roemani Hospital Semarang.Method: This is descriptive-analytic research with a cross-sectional approach. Samples were hemodialysis patients at Roemani Hospital, Semarang, with a total number of samples was 80 people. The data taken are primary data derived from questionnaire interviews and results of laboratory investigations. Data analysis used the chi-square test and the Spearman test.Results: Statistical test results obtained for the variable gender p = 0.358, education p= 0.462, employment p = 0.239, comorbid diseases p = 0.347, length of time undergoing hemodialysis p = 0.024, psychological function p = 0.280, family supports p=0.526, age r = 0.001 and p = – 0.992, hemoglobin r = 0.129 and p = 0.254, urea r = -0.089 and p = 0.432, creatinine r = 0.022 and p = 0.844. Based on these results, there was no relationship between age, gender, educational level, employment, comorbid disease, psychological functioning, family supports, hemoglobin, urea, and creatinine levels, and there was a significant relationship between the length of time undergoing hemodialysis and the quality of life of hemodialysis patients at Roemani Hospital Semarang.
Extract-Transform-Load for Video Streams
Authors: Kossmann Ferdi , Wu Ziniu , Lai Eugenie , Tatbul Nesime , Cao Lei , Kraska Tim , Madden Sam
Published: July 2023

Social media, self-driving cars, and traffic cameras produce video streams at large scales and cheap cost. However, storing and querying video at such scales is prohibitively expensive. We propose to treat large-scale video analytics as a data warehousing problem: Video is a format that is easy to produce but needs to be transformed into an application-specific format that is easy to query. Analogously, we define the problem of Video Extract-Transform-Load (
V-ETL
).
V-ETL
systems need to reduce the cost of running a user-defined
V-ETL
job while also giving throughput guarantees to keep up with the rate at which data is produced. We find that no current system sufficiently fulfills both needs and therefore propose
Skyscraper
, a system tailored to
V-ETL. Skyscraper
can execute arbitrary video ingestion pipelines and adaptively tunes them to reduce cost at minimal or no quality degradation, e.g., by adjusting sampling rates and resolutions to the ingested content.
Skyscraper
can hereby be provisioned with cheap on-premises compute and uses a combination of buffering and cloud bursting to deal with peaks in workload caused by expensive processing configurations. In our experiments, we find that
Skyscraper
significantly reduces the cost of
V-ETL
ingestion compared to adaptions of current SOTA systems, while at the same time giving robustness guarantees that these systems are lacking.
Pando: Enhanced Data Skipping with Logical Data Partitioning
Authors: Sudhir Sivaprasad , Tao Wenbo , Laptev Nikolay , Habis Cyrille , Cafarella Michael , Madden Samuel
Published: July 2023

With enormous volumes of data, quickly retrieving data that is relevant to a query is essential for achieving high performance. Modern cloud-based database systems often partition the data into blocks and employ various techniques to skip irrelevant blocks during query execution. Several algorithms, often based on historical properties of a workload of queries run over the data, have been proposed to tune the physical layout of data to reduce the number of blocks accessed. The effectiveness of these methods at skipping blocks depends on what metadata is stored and how well the physical data layout aligns with the queries. Existing work on automatic physical database design misses significant opportunities in skipping blocks because it ignores logical predicates in the workload that exhibit strongly correlated results. In this paper, we present Pando which enables significantly better block skipping than past methods by informing physical layout decisions with correlation-aware logical partitioning. Across a range of benchmark and real-world workloads, Pando attains up to 2.8X reduction in the number of blocks scanned and up to 2.3X speedup in end-to-end query execution time over the state-of-the-art techniques.
Managing Climate Policies in Bulgaria’s Social Context
Authors: Peneva Teodora
Published: July 2023

The social impact of the EU’s climate policies is usually analysed putting the focus on climate neutrality goals, and not on citizens’ well-being. The affordability of energy and energy efficiency is rarely analysed through both running costs and investment costs. Unfortunately, when implemented, climate policies meet limitations from a number of social factors, including poverty and inequality, the share of disposable income spent on energy expenditure, and low incomes. They impact the population’s investment ability, and undermine the country’s capacity to overcome climate change challenges. In Bulgaria, there is no in-depth analysis of the overall economic and social impact of climate policies, despite the presence of separate studies partly examining some aspect or specific climate instrument. This article uses theoretical and secondary statistical methods and data to provide an analytical framework for such an analysis, and offers an identification of the social risks and a systematisation of the social factors impacting the management of climate policies set out in the National Energy and Climate Plan: a reduction of greenhouse gas emissions, an increase in energy efficiency, and an increase in the share of renewable energy sources in consumption.
O DILEMA DAS PLATAFORMAS E REDES DIGITAIS
Authors: Bortolazzo Sandro Faccin
Published: July 2023

O Dilema das Redes”, documentário da Netflix, adverte como as empresas de tecnologia usam informações de usuários para potencializar negócios.  Neste artigo, o objetivo é analisar como as plataformas digitais, inscritas na racionalidade neoliberal, têm produzido outras formas de docência e processos educativos. Trata-se de um estudo exploratório, seguindo dois movimentos. O primeiro adota a algoritmicidade (STALDER, 2018) e a Plataformização da Sociedade (VAN DIJCK, POELL E WAAL, 2018) como características estruturais na produção de sentidos. O segundo, seguindo Brown (2019), Dardot et.al (2021), Ball (2014), Foucault (1987; 2006), explora como as tecnologias digitais e o neoliberalismo se afinam a características incitadas nos sujeitos – flexibilidade, mobilidade, personalização–, permitindo pensar uma docência e processos educativos voláteis, e não mais atrelados a espaços físicos.
The inhibitory receptor Siglec‐G controls the severity of chronic lymphocytic leukemia
Authors: Röder Bettina , Fahnenstiel Hannah , Schäfer Simon , Budeus Bettina , Dampmann Maria , Eichhorn Melanie , Angermüller Sieglinde , Brost Claudia , Winkler Thomas H , Seifert Marc , Nitschke Lars
Published: July 2023

Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in adults in the Western world. B cell receptor (BCR) signaling is known to be crucial for the pathogenesis and maintenance of CLL cells which develop from mature CD5+ B cells. BCR signaling is regulated by the inhibitory co‐receptor Siglec‐G and Siglec‐G‐deficient mice have an enlarged CD5+ B1a cell population. Here, we determine how Siglec‐G expression influences the severity of CLL. Our results show that Siglec‐G deficiency leads to earlier onset and more severe course of the CLL‐like disease in the murine Eμ‐TCL1 model. In contrast, mice overexpressing Siglec‐G on the B cell surface are almost completely protected from developing CLL‐like disease. Furthermore, we observe a downmodulation of the human ortholog Siglec‐10 from the surface of human CLL cells. These results demonstrate a critical role for Siglec‐G in disease progression in mice, and suggest that a similar mechanism for Siglec‐10 in human CLL may exist.