bluuebunny/crossref_metadata_2025 huggingface dataset:
Movement-related beta ERD and ERS abnormalities in neuropsychiatric disorders
Authors: Peter Jaime , Ferraioli Francesca , Mathew Dave , George Shaina , Chan Cameron , Alalade Tomisin , Salcedo Sheilla A. , Saed Shannon , Tatti Elisa , Quartarone Angelo , Ghilardi M. Felice
Published: November 2022

Movement-related oscillations in the beta range (from 13 to 30 Hz) have been observed over sensorimotor areas with power decrease (i.e., event-related desynchronization, ERD) during motor planning and execution followed by an increase (i.e., event-related synchronization, ERS) after the movement’s end. These phenomena occur during active, passive, imaged, and observed movements. Several electrophysiology studies have used beta ERD and ERS as functional indices of sensorimotor integrity, primarily in diseases affecting the motor system. Recent literature also highlights other characteristics of beta ERD and ERS, implying their role in processes not strictly related to motor function. Here we review studies about movement-related ERD and ERS in diseases characterized by motor dysfunction, including Parkinson’s disease, dystonia, stroke, amyotrophic lateral sclerosis, cerebral palsy, and multiple sclerosis. We also review changes of beta ERD and ERS reported in physiological aging, Alzheimer’s disease, and schizophrenia, three conditions without overt motor symptoms. The review of these works shows that ERD and ERS abnormalities are present across the spectrum of the examined pathologies as well as development and aging. They further suggest that cognition and movement are tightly related processes that may share common mechanisms regulated by beta modulation. Future studies with a multimodal approach are warranted to understand not only the specific topographical dynamics of movement-related beta modulation but also the general meaning of beta frequency changes occurring in relation to movement and cognitive processes at large. Such an approach will provide the foundation to devise and implement novel therapeutic approaches to neuropsychiatric disorders.
Factors underlying masking release by voice-gender differences and spatial separation cues in multi-talker listening environments in listeners with and without hearing loss
Authors: Oh Yonghee , Hartling Curtis L. , Srinivasan Nirmal Kumar , Diedesch Anna C. , Gallun Frederick J. , Reiss Lina A. J.
Published: November 2022

Voice-gender differences and spatial separation are important cues for auditory object segregation. The goal of this study was to investigate the relationship of voice-gender difference benefit to the breadth of binaural pitch fusion, the perceptual integration of dichotic stimuli that evoke different pitches across ears, and the relationship of spatial separation benefit to localization acuity, the ability to identify the direction of a sound source. Twelve bilateral hearing aid (HA) users (age from 30 to 75 years) and eleven normal hearing (NH) listeners (age from 36 to 67 years) were tested in the following three experiments. First, speech-on-speech masking performance was measured as the threshold target-to-masker ratio (TMR) needed to understand a target talker in the presence of either same- or different-gender masker talkers. These target-masker gender combinations were tested with two spatial configurations (maskers co-located or 60° symmetrically spatially separated from the target) in both monaural and binaural listening conditions. Second, binaural pitch fusion range measurements were conducted using harmonic tone complexes around a 200-Hz fundamental frequency. Third, absolute localization acuity was measured using broadband (125–8000 Hz) noise and one-third octave noise bands centered at 500 and 3000 Hz. Voice-gender differences between target and maskers improved TMR thresholds for both listener groups in the binaural condition as well as both monaural (left ear and right ear) conditions, with greater benefit in co-located than spatially separated conditions. Voice-gender difference benefit was correlated with the breadth of binaural pitch fusion in the binaural condition, but not the monaural conditions, ruling out a role of monaural abilities in the relationship between binaural fusion and voice-gender difference benefits. Spatial separation benefit was not significantly correlated with absolute localization acuity. In addition, greater spatial separation benefit was observed in NH listeners than in bilateral HA users, indicating a decreased ability of HA users to benefit from spatial release from masking (SRM). These findings suggest that sharp binaural pitch fusion may be important for maximal speech perception in multi-talker environments for both NH listeners and bilateral HA users.
Social relationship modulates advisor’s brain response to advice-giving outcome evaluation: Evidence from an event-related potential study
Authors: Zhang Can , Tao Ruiwen , Zhao Hanxuan , Zheng Kexin , Dai Mengge , Xu Sihua
Published: November 2022

Introduction

Advice-giving is a double-edged sword in social interaction, which could bring benefits or considerable losses for the advisee. However, whether the social relationship affects the time course of advisor’s brain response to outcome evaluation after the advice-giving remains unclear.

Methods

In the present study, we used event-related potentials (ERPs) to investigate the modulation of social relationships on advisor’s outcome feedback processing after the advice-giving and related neural activities.

Results

The results showed larger feedback-related negativity (FRN) to a loss than to a gain both when the friends accepted and rejected the advice, whereas this effect only existed when the strangers rejected the advice, but not when they accepted it. In contrast, the P3 results demonstrated the enhanced neural sensitivity when the strangers accepted the advice than rejected it despite leading to a loss, while a larger P3 amplitude was found when the friends accepted the advice than rejected it and brought a gain. The theta oscillation results in the friend group revealed stronger theta power to loss when the advisee accepted the advice than rejected it. However, this effect was absent in the stranger group.

Discussion

These results suggested that outcome evaluation in advice-giving was not only influenced by feedback valence and social reward, but also modulated by social relationships. Our findings contributed to the understanding of the neural mechanisms of advice-giving outcome evaluation in a social context.
Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study
Authors: Liu Su , Luo Jianfeng , Xiao Zhenxu , Wu Wanqing , Liang Xiaoniu , Ding Saineng , Zhao Qianhua , Zhao Xianfeng , Wang Yi , Ding Ding
Published: November 2022

Background

Growing evidence has shown the association between vitamin E intake and the risk of cognitive decline, but the conclusions were inconsistent. This study aimed to verify the hypothesis that vitamin E intake is associated with incident dementia and deterioration of global cognition.

Materials and methods

We followed 1,550 non-demented community residents aged ≥60 years for an average of 5.2 years in the Shanghai Aging Study. Baseline vitamin E intake were measured by the Food Frequency Questionnaire. Cognitive function was evaluated by a battery of neuropsychological tests. Consensus diagnosis of incident dementia was made based on the DSM-IV criteria.

Results

During the follow-up, 135 cases (8.7%) of incident dementia were identified. The incidence rates of dementia in low, low-medium, medium-high, and high vitamin E intake groups were 2.8, 1.5, 1.6, and 0.7 per 100 person-years, respectively (P < 0.001). Participants with low vitamin E intake had a significantly higher risk of incident dementia than those with higher intake [compared with the highest intake group: hazard ratio (HR) 2.34, 95% confidence interval (CI) 1.20–4.57] after adjusting for confounders. Vitamin E intake was negatively correlated to the rate of annual decline of Mini-Mental State Examination score with the adjustment of confounders (β = 0.019, p = 0.001).

Conclusion

Vitamin E intake is negatively correlated with the risk of dementia in older adults. An appropriate high amount of vitamin E intake from the diet might be helpful to prevent future cognitive decline.
Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications
Authors: Qiu Zhiyuan , Wang Yan , Zhang Zhao , Qin Rong , Peng Yong , Tang Weifeng , Xi Yan , Tian Guangyu , Zhang Yeqing
Published: November 2022

Colorectal cancer (CRC) is a major global health problem and one of the major causes of cancer-related death worldwide. It is very important to understand the pathogenesis of CRC for early diagnosis, prevention strategies and identification of new therapeutic targets. Intercellular adhesion molecule-1 (ICAM-1, CD54) displays an important role in the the pathogenesis of CRC. It is a cell surface glycoprotein of the immunoglobulin (Ig) superfamily and plays an essential role in cell-cell, cell-extracellular matrix interaction, cell signaling and immune process. It is also expressed by tumor cells and modulates their functions, including apoptosis, cell motility, invasion and angiogenesis. The interaction between ICAM-1 and its ligand may facilitate adhesion of tumor cells to the vascular endothelium and subsequently in the promotion of metastasis. ICAM-1 expression determines malignant potential of cancer. In this review, we will discuss the expression, function, prognosis, tumorigenesis, polymorphisms and therapeutic implications of ICAM-1 in CRC.
Prevention and management of human cytomegalovirus in pediatric HSCT recipients: A review
Authors: Hiskey Lisa , Madigan Theresa , Ristagno Elizabeth H. , Razonable Raymund R. , Ferdjallah Asmaa
Published: November 2022

Cytomegalovirus (CMV), like other herpesviruses, has the unique ability to establish latent infection with subsequent reactivation during periods of stress and immunosuppression. Herpesviruses cause potentially devastating disease, particularly in hematopoietic stem cell transplant (HSCT) recipients. CMV is especially of concern in HSCT recipients given the high community seroprevalence, high risk of reactivation and high risk of transmission from HSCT donors to recipients causing primary infection after transplantation. The risk of CMV infection and severity of CMV disease varies depending on the underlying disease of the HSCT recipient, donor and recipient CMV status prior to HSCT, type of conditioning therapy in preparation for HSCT, allogeneic versus autologous HSCT, donor graft source, timing of infection in relation to HSCT, and other patient comorbidities. Different strategies exist for prevention (e.g., preemptive therapy vs. universal prophylaxis) as well as management of CMV disease (e.g., antiviral therapy, augmenting immune reconstitution, cytotoxic T-cell therapy). The purpose of this narrative review is to discuss diagnosis, prevention, and management of CMV infection and disease at different stages of HSCT, including key points illustrated through presentations of complex cases and difficult clinical scenarios. Traditional and novel strategies for CMV management will be discussed in the context of these unique clinical cases.
Incidence of retinoblastoma in children and adolescents in Brazil: A population-based study
Authors: Barbosa Annamaria Ciminelli , de Magalhães-Barbosa Maria Clara , Moreira Jessica Pronestino de Lima , Colombini Giovanni Nicola Umberto Italiano , Prata-Barbosa Arnaldo
Published: November 2022

Objective

To estimate the incidence of retinoblastoma in children and adolescents in Brazil based on Population-Based Cancer Registry (PBCR), describing temporal trends and some quality indicators of this registry.

Methods

Based on secondary data from the PBCR of the National Institute of Cancer (INCA) (2000–2018), by selecting the morphological code of retinoblastoma, the annual incidences per million (0–19 years of age) in each local PBCR were estimated by sex and age group, global combined and by region, in addition to the percentage of diagnosis only by death certificate (DC) or not informed (NI), and the male/female ratio (M/F). An annual incidence trend in the five Brazilian geographic regions was also analyzed using the inflection point regression technique.

Results

675 patients were identified in 28 PBCR, 91% between 0 and 4 years of age. The overall combined incidence per million by age group was: 7.02 (0–4 years old), ranging from 5.25 in the Midwest to 11.26 in the Northeast; 0.46 (5–9 years old); 0.05 (10–14 years old) and 0.03 (15–19 years old). The combined incidence per million, adjusted for the world population, was 2.23 (0–14 years old) and 2.24 (0–19 years old). The DC and NI percentages were 13% and 18%, respectively; the M/F ratio was 1.3. The incidence remained stable throughout the study period, except for the city of São Paulo, where there was a significant reduction of 3.4% per year.

Conclusions

In Brazil, except for the Northeast region, the incidences of retinoblastoma were lower than those reported in several countries worldwide, suggesting possible underreporting, and the time series analysis showed a stable trend. Although this pioneering study brings a recent panel of available data on retinoblastoma in Brazil, more precise estimates are needed and welcome for better planning of onco-ophthalmologic care in the country.
Effectiveness of unilateral sequential video-assisted sympathetic chain blockage for primary palmar hyperidrosis in children and adolescents
Authors: Adorisio Ottavio , Davoli Enrico , Ceriati Emanuela , Battaglia Sonia , Camanni Daniela , De Peppo Francesco
Published: November 2022

Introduction

Primary palmar hyperhidrosis (PPH) is a severely debilitating condition that can affect patients of any age. Thoracoscopic sympathectomy provides a definitive treatment for PPH. Aim of this study is to investigate the effectiveness of unilateral sequential video-assisted thoracic sympathetic chain clamping (VATSCC) by clips application in pediatric population.

Methods

The surgical procedure was done in the semi-sitting position, under general anesthesia with orotracheal intubation. Mean operation time was 23 ± 6 min (range 12–45). Two 5 mm ports were inserted at the level of the middle axillary line in the second and fourth intercostal space respectively. The sympathetic chain was identified, and two clips were applied, the first one at the level of the third and the second one, at the level of the fourth rib. No chest tube was used. Resolution of symptoms, complications, recurrence rate, onset and duration of compensatory hyperhidrosis were analyzed.

Results

From August 2017 to September 2021, 58 patients (male:female ratio 32:26), mean age 16.5 years (range 14–19), with PPH underwent unilateral sequential VATSCC by clips application, starting on the dominant hand. The contralateral side was operated 2 months after. All patients except one (transient pneumothorax) were discharged on the first post-op day. No immediate or late complications have been recorded. Mean follow-up was 32 months (range 6–41). All patients except one (1,7%), affected by Raynaud's disease, showed a complete resolution of the symptom. Seven patients (12%) developed transient moderate compensative hyperhidrosis (CH) that spontaneously disappeared in the postoperative period.

Conclusions

Unilateral sequential thoracoscopic sympathetic chain clamping for PPH in pediatric patients is a safe and very effective procedure with a low complication rate and low incidence of postoperative CH that, in our experience, resolved spontaneously in the postoperative period, after the second surgery leading to an improvement in the quality of life.
Fuzheng Nizeng Decoction regulated ferroptosis and endoplasmic reticulum stress in the treatment of gastric precancerous lesions: A mechanistic study based on metabolomics coupled with transcriptomics
Authors: Chu Ying-Ming , Wang Ting-Xin , Jia Xiao-Fen , Yang Yao , Shi Zong-Ming , Cui Guang-Hui , Huang Qiu-Yue , Ye Hui , Zhang Xue-Zhi
Published: November 2022

Background: Fuzheng Nizeng Decoction (FZNZ) has a history of decades in gastric precancerous lesions (GPL) treatment, which has shown clear clinical efficacy. Blocking GPL is a key measure to reduce the incidence of gastric cancer (GC). Therefore, we aim to investigate the mechanism of FZNZ-induced ferroptosis and endoplasmic reticulum (ER) in MNNG-induced gastric precancerous lesion (MC) cells, which has been rarely studied in Traditional Chinese Medicine (TCM).

Methods: First, CCK8 and lactate dehydrogenase assays were conducted to study the potential effect of FZNZ on MC cells. Second, combined transcriptomic and metabolomic analysis were used to explore the effect and mechanism of FZNZ. Functionally, the occurrence of ferroptosis was assessed by transmission electron microscopy morphological observation and measurement of ferrous iron levels, lipid peroxidation, and glutathione levels. Finally, the expression levels of mRNAs or proteins related to ferroptosis and ER stress were determined by qPCR or western blot assays, respectively.

Results: FZNZ inhibited MC cells viability and induced cell death. By metabolomics coupled with transcriptomics analysis, we found that the mechanism of FZNZ treatment induced ferroptosis and was related to glutathione metabolism and ER stress. We then, for the first time, found that FZNZ induced ferroptosis, which contributed to an increase in intracellular ferrous iron, reactive oxygen species, and malondialdehyde and a decrease in glutathione. Meanwhile, the protein level of glutathione peroxidase 4 (GPX4) was decreased. The mRNA levels of ATF3/CHOP/CHAC1, which are related to ferroptosis and ER stress, were also upregulated.

Conclusion: Our results elaborate that FZNZ could induce ferroptosis and ER stress in MC cells, and reduce GPX4/GSH. ATF3/CHOP/CHAC1 may play a crosstalk role, which provides a new molecular mechanism for the treatment of GPL.
Multiclass classification using quantum convolutional neural networks with hybrid quantum-classical learning
Authors: Bokhan Denis , Mastiukova Alena S. , Boev Aleksey S. , Trubnikov Dmitrii N. , Fedorov Aleksey K.
Published: November 2022

Multiclass classification is of great interest for various applications, for example, it is a common task in computer vision, where one needs to categorize an image into three or more classes. Here we propose a quantum machine learning approach based on quantum convolutional neural networks for solving the multiclass classification problem. The corresponding learning procedure is implemented via TensorFlowQuantum as a hybrid quantum-classical (variational) model, where quantum output results are fed to the softmax activation function with the subsequent minimization of the cross entropy loss via optimizing the parameters of the quantum circuit. Our conceptional improvements here include a new model for a quantum perceptron and an optimized structure of the quantum circuit. We use the proposed approach to solve a 4-class classification problem for the case of the MNIST dataset using eight qubits for data encoding and four ancilla qubits; previous results have been obtained for 3-class classification problems. Our results show that the accuracy of our solution is similar to classical convolutional neural networks with comparable numbers of trainable parameters. We expect that our findings will provide a new step toward the use of quantum neural networks for solving relevant problems in the NISQ era and beyond.
Learning behavior, digital platforms for learning and its impact on university student’s motivations and knowledge development
Authors: Noor Uzma , Younas Muhammad , Saleh Aldayel Hessah , Menhas Rashid , Qingyu Xu
Published: November 2022

Background

Learning digital technologies in higher education is a process of knowledge generation, and the rapid growth of technology in education has a significant impact on students’ learning behaviors, motivation, and knowledge development. Pakistan’s remarkable technological breakthrough has increased in the education field.

Study objectives

The study focuses on estimating students’ learning behaviors, identifying the positive influence of educational apps on digital learning platforms, and analyzing their impact on students’ motivation and knowledge development.

Materials and methods

According to the study’s objectives, a questionnaire survey was conducted to gather the primary data. The participants were students of universities in Lahore city of Pakistan. For this study, the sample size was N = 300, carefully chosen using the purposive sampling technique. Of the respondents, there were 146 male and 154 female students, and the sample consisted of individuals aged 25–35 years. Smart-PLS-Bootstrapping, T-Values (PLS) 3.2.9 and the structural equation model (SEM) were applied to get the appropriate outcomes from the proposed study framework.

Results

SEM analysis results shows that all proposed hypotheses [Animated Movies (AM) –> Student Motivation (SM), Educational Apps (EA) –> Knowledge Development (KD), Learning Behavior (LB) –> Animated Movies, Learning Behavior –> Educational Apps, Learning Behavior –> Knowledge Development, Learning Behavior –> Virtual Classrooms (VCr), Virtual Classrooms –> Knowledge Development, Virtual Classrooms –> Student Motivation] are confirmed while Learning Behavior –> Student Motivation is not confirmed.

Conclusion

This study found that digital learning platforms significantly impact students’ learning and what motivates them to learn. The study also found that using educational apps and virtual classrooms more often helps students learn more and be more motivated to learn.
Reducing anxiety and attentional bias with reward association learning and attentional bias modification
Authors: Xiao Wen , Zheng Xiaoqi , Luo Yuejia , Peng Jiaxin
Published: November 2022

The current study examined the effects of a reward associative learning procedure and the traditional threat-avoidance ABM paradigm on anxiety and attentional bias. In reward training, participants were given high rewards for correct responses to neutral target and low rewards for correct responses to negative target. In reward control training, participants received no cues of rewards after their responses. High trait anxious individuals (N = 76) first completed a session of reward training or reward control training, followed by four sessions of ABM training or ABM control training. Generalized anxiety disorder symptom (GAD-7) and attentional bias in a dot-probe task were assessed during pre-and post-training. Results indicated that the effect of ABM training on reducing anxiety was only obtained in the reward training condition. Participants who received reward training showed significantly less attentional bias compared with those receiving reward control training. There was no significant training effect of ABM on atttentiona bias. Results suggested that reward training reduced general anxiety and attentional bias. Traditional ABM training reduced anxiety only when combined with reward training. Attentional bias in anxiety are modifiable through reward training.
Warming and cooling effects of local climate zones on urban thermal environment
Authors: Zhang Rui , Yang Jun , Sun Dongqi , Ma Xinyue , Yu Wenbo , Xiao Xiangming , Xia Jianhong (Cecilia)
Published: November 2022

Understanding the thermal characteristics and contribution ranking of local climate zones (LCZs) is essential since they can help in maintaining environmental harmony. However, previous studies only considered independent effects and could not analyze the combined effects of LCZ on land surface temperature (LST). In this study, we propose a new method to establish an interaction model between LCZs. Five first-level grids with different scales from 270 to 990 m were established to calculate the area proportion of LCZ. The area proportion of LCZ was then applied in the stepwise regression model to quantitatively analyze its magnitude and direction of impact on the LST. The results suggest that the LCZ types of the study area with the highest and lowest average LST were LCZ2 (compact middle-rise building, 39.82°C) and LCZG (water body, 34.24°C), respectively. However, on most scales, the warming effect of LCZ2 was lower than that of LCZE (bare rock or paver), and the cooling effect of LCZG was lower than that of LCZD (low plants). The optimum results were obtained at a scale of 810 m. At this scale, the warming effect was in the order: LCZE (0.314) > LCZ2 (0.236) > LCZ3 (compact low-rise building, 0.135) > LCZ5 (open middle-rise, 0.084) > LCZ6 (open low-rise, 0.056); the cooling effect was in the order: LCZD (−0.272) > LCZA (dense trees, −0.104) > LCZG (−0.103). These findings can help to elucidate the unique warming and cooling effects of LCZ on the interaction condition and the construction of an urban human settlement.
Explanatory machine learning for justified trust in human-AI collaboration: Experiments on file deletion recommendations
Authors: Göbel Kyra , Niessen Cornelia , Seufert Sebastian , Schmid Ute
Published: November 2022

In the digital age, saving and accumulating large amounts of digital data is a common phenomenon. However, saving does not only consume energy, but may also cause information overload and prevent people from staying focused and working effectively. We present and systematically examine an explanatory AI system (Dare2Del), which supports individuals to delete irrelevant digital objects. To give recommendations for the optimization of related human-computer interactions, we vary different design features (explanations, familiarity, verifiability) within and across three experiments (N1= 61,N2= 33,N3= 73). Moreover, building on the concept of distributed cognition, we check possible cross-connections between external (digital) and internal (human) memory. Specifically, we examine whether deleting external files also contributes to human forgetting of the related mental representations. Multilevel modeling results show the importance of presenting explanations for the acceptance of deleting suggestions in all three experiments, but also point to the need of their verifiability to generate trust in the system. However, we did not find clear evidence that deleting computer files contributes to human forgetting of the related memories. Based on our findings, we provide basic recommendations for the design of AI systems that can help to reduce the burden on people and the digital environment, and suggest directions for future research.
Methodology for assessing the maximum potential impact of separations opportunities in industrial processes
Authors: Liu Jian , Dempsey Jacob W. , Li Shuyun , Jiang Yuan , Snowden-Swan Lesley J. , Kubic William L. , Tan Eric C. D. , Freeman Charles J.
Published: November 2022

Separation technologies currently used in U.S. manufacturing industries are estimated to account for more than 20% of plant energy consumption. However, accurately determining the impact of new separation technology solutions can sometimes be difficult, especially when evaluating a slate of new candidate separation technologies, each of which has its own separation performance, energy demand, and capital cost. In these cases, a typical approach is to assess each new separation technology by collecting performance and cost information and then using that information to develop a techno-economic analysis to identify overall benefits. While this approach is thorough, it can be time consuming and can hinder reaching a critical understanding of the potential of a given separation challenge, especially when there is no known solution. To address these issues, we developed an assessment methodology, using industrial screening processes, that can be used to better understand the potential impacts of addressing a given separation challenge. This paper presents an overview of our separation challenge stream assessment methodology. The methodology involves defining an “ideal” separator and deriving the associated minimum separation energy. The “ideal” separator represents the most optimistic outlook of a given opportunity so the maximum impact from existing and not-yet-developed solutions can be assessed. Using established biorefinery models, we applied the methodology to 10 different separation challenge streams from two different biomass conversion platforms to identify the type of information that can be obtained. Three of the ten challenge streams assessed had maximum possible cost savings predictions >20%, and associated reductions in process energy carbon intensity ranging from 0 to 54%. Two streams had cost and energy savings potential that were < 5%. Some of the opportunity drivers from the various assessments include higher product yields, reduction or elimination of downstream equipment, new co-products, and cost savings associated with raw materials and energy consumption. The information from these assessments can help guide the selection or development of new separation technology solutions based on the various potential factors that drive the projected benefits.
Virtual consumption: A review of digitalization's “green” credentials
Authors: Hynes Mike
Published: November 2022

The unprecedented development, growth, and widespread pervasiveness of digital Information Communication Technologies (ICTs) have coincided with ever-increasing levels of consumption and the climate emergency. Digital ICTs, once lauded for their potential to dematerialize society, are now imposing additional burdens on the planet. The widespread consumption of personal electronics continues to grow at an enormous rate, while recycling of the scarce rare-earth minerals that are crucial to their development is negligible. As digital technologies become ubiquitous, the need for additional energy to power our ever-increasing number of digital devices and services must also keep pace. Moreover, despite their public veneer as progressives, digital tech companies are collaborating with fossil fuel companies to render oil and gas extraction more profitable and with greater speed, fuelling climate breakdown. Online social platforms are also being misused as podiums for dis/misinformation and falsehoods counter to the scientific consensus of anthropogenic climate change, allowing the digital tech sector to abdicate any social responsibility and denying the dire consequences of inaction. This review article explores the growing consumption demands and the ecological threat from digitalization and the digital tech sector: demands that will only intensify with our insatiable appetite for digital tech services and products. Such a review aims to draw closer attention to some ways such technology can be used to assist ecological research and conservation, but also to expand upon our understanding of the negative environmental aspects of a relentless push toward a Digital Society. In uncritically accepting Big Tech's virtuous credentials, we are choosing to ignore the immense power and influence they have over our lives, and the ways they may be propelling our environment toward collapse.
Why Should I Learn Music? It Can Be Good for Your Brain!
Authors: Ficek-Tani Bronte , Habibi Assal
Published: November 2022

Imagine a world without music—no summer concerts, no holiday sing-alongs, no dramatic orchestra music in movies leading to epic battle scenes. Would not that be terrible? Musicians train for a long time to create and play music. Playing music brings us pleasure and connects us to one another. Research shows that playing music also contributes to our overall health and wellbeing and helps our thinking and planning skills. In this article, we will first talk about how various parts of the brain are engaged to make music playing possible. We will also discuss benefits of music learning for the brain, including our thinking abilities and social skills. We hope that this article provides examples and evidence that making music is not only fun, but it can also benefit our overall wellbeing.
Muons, mutations, and planetary shielding
Authors: de Groen Piet C.
Published: November 2022

Life on earth is protected from astrophysical cosmic rays by the heliospheric magnetic and slowly varying geomagnetic fields, and by collisions with oxygen and nitrogen molecules in the atmosphere. The collisions generate showers of particles of lesser energy; only muons, a charged particle with a mass between that of an electron and a proton, can reach earth’s surface in substantial quantities. Muons are easily detected, used to image interior spaces of pyramids, and known to limit the stability of qubits in quantum computing; yet, despite their charge, average energy of 4 GeV and ionizing properties, muons are not considered to affect chemical reactions or biology. In this Perspective the potential damaging effects of muons on DNA, and hence the repercussions for evolution and disease, are examined. It is argued here that the effect of muons on life through DNA mutations should be considered when investigating the protection provided by the magnetic environment and atmosphere from cosmic rays on earth and exoplanets.
Short-term and mid-term effects of thoracoscopic repair of esophageal atresia: No anastomotic leaks or conversions to open technique
Authors: Galazka Przemyslaw , Skinder Dominika , Styczynski Jan
Published: November 2022

The frequency rate of esophageal anastomosis leaks after thoracoscopic correction of esophageal atresia (EA) in the current literature is reported as 5.6%–24.7% and a conversion rate of 2%–53%. The objective of this retrospective study was to examine the characteristics of EA and analysis of the safety and efficacy of EA repair with the use of the thoracoscopic approach in a single academic center, as well as risk factors analysis in the context of short-term and mid-term follow-up status. A retrospective analysis of the management of all consecutive newborns affected by EA hospitalized in our department over a period between 2013 and 2022, including preoperative, perioperative, and postoperative management, together with the outcome, complications and long-term follow-up status was performed. A total of 38 patients with a median birth weight of 2,570 g (range; 1,020–3,880) were treated over the study period, including 30/38 (78.9%) with additional congenital anomalies. Overall, 30 patients underwent primary anastomosis of the esophagus and eight underwent a multistaged procedure, with or without an initial ligation of the tracheoesophageal fistula and delayed primary anastomosis. Overall survival for all patients was 0.894 ± 0.050, with a median follow-up of 4.5 years. We noted neither anastomotic leaks nor conversions to open technique in our cohort. Implementation of vancomycin prophylaxis was successful in preventing postoperative central venous access-related infectious complications. At the end of the follow-up, 85% of patients have a Lansky performance score ≥80. Risk factors analysis for length of hospitalization, overall survival, Lansky performance status, and neurological impairment were analyzed. In conclusion, we have found that the outcome of thoracoscopic repair of EA in terms of surgery-dependent morbidity (anastomosis leakage, conversion rate to open surgery), provides benefit to those previously reported in the literature, regardless of the prognostic criteria of the classification system.
Genome-wide association study reveals novel candidate genes for litter size in Markhoz goats
Authors: Mahmoudi Peyman , Rashidi Amir , Nazari-Ghadikolaei Anahit , Rostamzadeh Jalal , Razmkabir Mohammad , Huson Heather Jay
Published: November 2022

Introduction

The Markhoz goat is the only breed that can produce high-quality fiber called mohair in Iran; however, the size of its population has faced a dramatic decline during the last decades, mainly due to the reluctance of farmers to rear Markhoz goats caused by a reduction in goat production income. Litter size at birth (LSB) and weaning (LSW) are two economically important reproductive traits for local goat breeders and have the potential of increasing the population growth rate. The present study was aimed to identify possible genomic regions that are associated with LSB and LSW in Markhoz goats using a genome-wide association study (GWAS).

Methods

To this end, 136 Markhoz goats with record(s) of kidding were selected for GWAS using the Illumina Caprine 50K bead chip. The individual breeding values (BV) of available LSB and LSW records estimated under an animal mixed model were used as the dependent variable in the GWAS, thereby incorporating repeated categorical variables of litter size.

Results

Four SNPs on chromosomes 2, 20 and 21 were identified to be significantly associated (FDR p < 0.05) with LSB after multiple testing correction under a Bayesian-information and Linkage-disequilibrium Iteratively Nested Keyway (BLINK) model. Least-square analysis was performed to investigate the effects of detected genotypes on LSB. Ultimately, the GWAS results introduced six candidate genes, including GABRA5, AKAP13, SV2B, PPP1R1C, SSFA2 and TRNAS-GCU in a 100 kb adjacent region of the identified SNPs. Previous studies proposed functional roles of GABRA5 and AKAP13 genes in reproductive processes; however, the role of other candidate genes in reproduction is not clear.

Conclusion

These findings warrant further investigation for use in marker-assisted selection programs in Markhoz goats.
Pulmonary Combined Large Cell Neuroendocrine Carcinoma
Authors: Li Meihui , Yang Lan , Lu Hongyang
Published: November 2022

Pulmonary combined large-cell neuroendocrine carcinoma (CLCNEC) is a rare neuroendocrine tumor pertained to lung large cell neuroendocrine carcinoma (LCNEC) with aggressive behavior and poor prognosis generally. The clinical features of CLCNEC are not specific including cough, expectoration, chest distress, chest pain, etc., which are prone to have different manifestations of the mixed components. Owing to the low incidence, there are few related small-scale retrospective studies and case reports. Currently, the treatment regimen of CLCNEC mainly refers to LCNEC that complete surgical resection is preferred in the early stage and according to previous researches, platinum-based small cell lung cancer (SCLC) standard treatment regimen showed promising results in postoperative and advanced CLCNEC as compared to that of non-small cell lung cancer (NSCLC). Adenocarcinoma-CLCNEC more likely harbor driver gene mutation, and may benefit from targeted therapy. As for immunotherapy, more clinical trial data are needed to support its benefits. This article will fill the gap and will provide new insight into the clinical characteristics, pathological diagnosis and treatment endeavors of CLCNEC.
Operando Observation of Coupled Discontinuous-Continuous Transitions in Ion-Stabilized Intercalation Cathodes
Authors: Zhang Guobin , Xiong Tengfei , Xia Lixue , Yao Xuhui , Zhao Yan , Zheng Lirong , Chen Han , Zhao Yunlong , Yan Mengyu
Published: November 2022

Irreversible phase transition caused capacity fading has been considered as an obstacle for rechargeable batteries. An in-depth investigation of the irreversible phase transition is critical for understanding the reaction mechanism and developing advanced batteries. In this work, taking vanadium oxide and its alkali ion-stabilized intercalation compounds (A-V-O, A = Li, Na, K) as prototypes, utilizing operando characterizations, we discovered coupled discontinuous (interlayer)-continuous (intralayer) transitions in the stabilized multielectron intercalation cathodes. The highly ordered crystal of vanadium pentoxide irreversibly transfers to a disordered/amorphous structure after the first cycle, whereas A-V-O enables reversible discontinuous lattice transitions at the interlayer pathway for facilitating lithium diffusion. Among the A-V-O family, K-V-O, with the highest capacity retention, shows a coupled discontinuous-continuous transition, which exhibits a continuous transition and the minimum volume change at the V-O intralayer during lithium intercalation/deintercalation. These coupled discontinuous-continuous lattice transitions were captured for the first time in cathode materials. It implies that the suitable ion intercalation induced continuous intralayer transition inhibits the irreversible ion intercalation and phase transition.
Investigation on the Modeling and Reconstruction of Head Injury Accident Using ABAQUS/Explicit
Authors: Deng Xingqiao , Du Zhifei , Feng Huiling , Wang Shisong , Luo Heng , Liu Yucheng
Published: November 2022

A process of modeling and reconstructing human head injuries involved in traffic crashes based on ABAQUS/Explicit is presented in this paper. A high-fidelity finite element (FE) model previously developed by the authors is employed to simulate a real accident case that led to head injury. The most probable head impact position informed by CT images is used for the FE modeling and simulation since the head impact position is critical for accident reconstruction and future analysis of accidents that involve human head injuries. Critical von Mises stress on the skull surface of the head model is chosen as the evaluation criterion for the head injury and FE simulations on 60 cases with various human head—concrete ground impact conditions (impact speeds and angles) were run to obtain those stress values. The FE simulation results are compared with the CT images to determine the minimum speed that will cause skull fracture and the corresponding contact angle at that speed. Our study shows that the minimum speed that would cause skull fracture is 3.5 m/s when the contact angle between the occipital position of the injured head and the ground is about 30°. Effects of the impact speed and the contact angle on the maximum von Mises stress of the head model are revealed from the simulations. The method presented in this paper will help forensic pathologists to examine the head impact injuries and find out the real reasons that lead to those injuries.
Chromosome-Level Genome Assembly and Multi-Omics Dataset Provide Insights into Isoflavone and Puerarin Biosynthesis in Pueraria lobata (Wild.) Ohwi
Authors: Cheng Hua , Huang Xiaohua , Wu Shuai , Wang Shiyan , Rao Shen , Li Li , Cheng Shuiyuan , Li Linling
Published: November 2022

Pueraria lobata (wild.) Ohwi is a leguminous plant and one of the traditional Chinese herbal medicines. Its puerarin extract is widely used in the pharmaceutical industry. This study reported a chromosome-level genome assembly for P. lobata and its characteristics. The genome size was ~939.2 Mb, with a contig N50 of 29.51 Mbp. Approximately 97.82% of the assembled sequences were represented by 11 pseudochromosomes. We identified that the repetitive sequences accounted for 63.50% of the P. lobata genome. A total of 33,171 coding genes were predicted, of which 97.34% could predict the function. Compared with other species, P. lobata had 757 species-specific gene families, including 1874 genes. The genome evolution analysis revealed that P. lobata was most closely related to Glycine max and underwent two whole-genome duplication (WGD) events. One was in a gamma event shared by the core dicotyledons at around 65 million years ago, and another was in the common ancestor shared by legume species at around 25 million years ago. The collinearity analysis showed that 61.45% of the genes (54,579 gene pairs) in G. max and P. lobata had collinearity. In this study, six unique PlUGT43 homologous genes were retrieved from the genome of P. lobata, and no 2-hydroxyisoflavanone 8-C-glucoside was found in the metabolites. This also revealed that the puerarin synthesis was mainly from the glycation of daidzein. The combined transcriptome and metabolome analysis suggested that two bHLHs, six MYBs and four WRKYs were involved in the expression regulation of puerarin synthesis structural genes. The genetic information obtained in this study provided novel insights into the biological evolution of P. lobata and leguminous species, and it laid the foundation for further exploring the regulatory mechanism of puerarin synthesis.
Biomechanical Characteristics of Long Stair Climbing in Healthy Young Individuals in a Real-World Study Using a Wearable Motion Analysis System
Authors: Yaguchi Haruki , Sekiguchi Yusuke , Honda Keita , Fukushi Kenichiro , Huang Chenhui , Nakahara Kentaro , Zhenzhao Cheng , Izumi Shin-Ichi
Published: November 2022

Background: Stair climbing is a part of the basic activities of daily living. Previous biomechanical analyses of stairs have been conducted in the laboratory, resulting in only a few steps. Therefore, the biomechanical characteristics of long stair climbing in the real world remain unclear. The purpose of this study was to identify differences in kinematic and kinetic in the lower limb between the beginning and end phases of long stair climbing in an outdoor environment using a wearable motion analysis system. Eight subjects (four males and four females) were included in the data analysis (age: 23.6 ± 0.5 years). The long stair was 66 consecutive steps out of 202 stone steps. A wearable motion analysis system comprised six inertial measurement units and foot pressure sensors. The maximum ankle joint flexion angle in the end phase was significantly increased more than in the beginning phase (p < 0.001). On the other hand, the other kinematic, kinetic, and stair climbing speeds showed no significant difference between the phases. The findings indicated that fatigue during long stair climbing might increase ankle dorsiflexion to compensate for forwarding propulsion.
Mechanisms of Seed-To-Seed Interactions between Dominant Species in the Yangtze River Estuary under Saline Condition
Authors: Wang Cheng-Huan , Yu Zhen-Lin , Yasenjiang Yuerenisha , Tang Long , Gao Yang , Zou Chun-Jing
Published: November 2022

Plant community assembly is the central issue in community ecology. As plant traits differ in different life history stages, the form, intensity and mechanism of interspecific interactions may change with the ontogenetic process of plants. However, our understanding of interspecific interaction mechanisms during germination is still limited. Here, we conducted a laboratory germination experiment using five dominant species in Chongming Dongtan (Spartina alterniflora, Scirpus mariqueter, Phragmites australis, Suaeda glauca and Tripolium vulgare) to assess their germination performance in control (monoculture), allelopathy and mixture treatments. The results indicated that seeds could affect germination performance of neighbors through both allelopathy and salinity modification. Salinity of the solution in Petri dishes after seed germination decreased significantly in most species combinations in competition treatment, and was negatively correlated with the number of total germinated seeds. Seed leachate of invasive Spartina alterniflora significantly accelerated the germination of two native halophytes Suaeda glauca and Tripolium vulgare, but not Scirpus mariqueter and Phragmites australis. The salt absorption by Spartina alterniflora seeds had inconsistent effects compared with that of its seed leachate. On the other hand, seed leachate of native Scirpus mariqueter and Phragmites australis significantly slowed down the germination of invasive Spartina alterniflora. The effect of salinity modification of Scirpus mariqueter on Spartina alterniflora was positive, whereas that of other species was neutral. Considering seed-to-seed interactions is an important perspective to understand the underlying mechanisms of community dynamics, species diversity maintenance and invasion of alien species, and can improve the effectiveness in the management of invaded coastal wetlands.