bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicación de un compost con aporte de silicio en cultivo de rosa (Rosa x hybrida)
Authors: Mejía-Carranza Jaime , Cruz-Chávez David , Alvarado- Hernández Rafael , Ramírez-Gerardo Marithza Guadalupe
Published: January 2023

El uso excesivo de agroquímicos para nutrir y controlar plagas encultivo de rosa (Rosa x hybrida) conlleva costos ambientales y económicos, por lo que se buscan alternativas para disminuir su utilización. El objetivo de la presente investigación fue obtener un compost elaborado con vegetales que aportan silicio y, evaluar su efecto en cuatro ciclos productivos de rosa cv. Freedom®, sobre la incidencia de araña roja (Tetranychus urticae), propiedades del suelo y calidad de flor. El diseño experimental fue bloques completos al azar con tres repeticiones, los tratamientos fueron, testigo sin aplicación (T0), compost (T1) y productos comerciales, Nubiotek Si® (T2) y Silex® + Silifertidol® (T3). Las características del compost obtenido fueron 35% de humedad, 34% de materia orgánica y 4.2dS m−1 de conductividad eléctrica, valores ubicados dentro de la normatividad mexicana, su aplicación mejoró significativamente (P < 0.05) la cantidad de materia orgánica y actividad microbiana en suelo, así como un menor número promediode tallos con presencia de ácaros, sin embargo, no se presentó una mejora en la calidad del cultivo y en el número promedio de T. urticae. La disponibilidad de siliciofue limitada y, por lo tanto, no fue suficiente para ejercer un efecto significativo en las variables evaluadas en los ciclos de cultivo.
Producción de chile habanero (Capsicum chinense Jacq.) en lombricomposta con fertilización orgánica
Authors: Javier-López Leonel , Palacios-Torres Rogelio Enrique , Ramírez-Seañez Ana Rosa , Hernández-Hernández Hipólito , Antonio-Luis María del Carmen , Yam-Tzec José Antonio , Chaires-Grijalva Martha Patricia
Published: January 2023

El uso indiscriminado de la  fertilización química en la producción agrícola, ha ocasionado daños de consideración al medio ambiente, por tal motivo se buscan alternativas de producción orgánica, que tenga efectos positivos en el rendimiento y calidad de los cultivos. El objetivo de la presente investigación fueevaluar el uso de diferentes sustratos en el crecimiento, rendimiento y calidad de fruto del chile habanero híbrido Chichen Itzá en invernadero, estableciendo cuatro tratamientos con los siguientes sustratos y sus mezclas: T1: lombricomposta al 100% con manejo orgánico (ORG-LOM); T2: mezcla de lombricomposta: sueloregional: grava en proporción 1:1:1 (v/v/v) con manejo orgánico (ORG-LSG); T3: mezcla de lombricomposta: arena de río: grava en proporción 1:1:1 (v/v/v) con manejo orgánico (ORG-LAG); y como testigo T4: arena de río con manejo químico (QUIM-AR). El experimento se estableció bajo un diseño de bloques completos alazar. El tratamiento ORG-LOM fue el que mostró los mejores resultados, altura promedio de planta de 192.6 cm, diámetro de tallo de 19.1 mm, número de floresy frutos de 33.84 y 35.8% respectivamente del total obtenido, y rendimiento por planta de 616.41 g, además, el peso de fruto fue de 7.8 g, con longitud de 35.7 mm, diámetro de 25.76 mm, grosor de pericarpio de 2.08 mm y número de lóculos de 3.44. En todas las variables evaluadas el tratamiento con sustrato lombricomposta al 100% y manejo orgánico (ORG-LOM) fue el que mejores resultados obtuvo.
Densidad de madera de especies arbóreas dominantes de la selva tropical subperennifolia de Calakmul, México
Authors: Chan-Coba Gabriel , De Jong Bernardus Hendricus Jozeph , González-Valdivia Noel Antonio , López-Hernández Juan Carlos , Morales-Ruiz Danilo Enrique , Venegas-Venegas José Apolonio , Reyes-Sosa Mariela , Aryal Deb Raj
Published: January 2023

La densidad de madera es un parámetro fundamental para la estimación precisa de biomasa arbórea en ecosistemas forestales. La selva subperennifolia del sureste mexicano se caracteriza por la alta diversidad arbórea, por lo cual es necesario estudiar las variaciones de densidad de madera. El objetivo del estudio fue determinar la variación de densidad de madera de las especies dominantes de la selva subperennifolia y generar modelos de regresión con el grosor diamétrico de madera. Se colectaron 3 260 muestras de madera de 23 especies, en tres categorías diamétricas (gruesa, mediana y delgada). Se midió el volumen de madera con la técnica de desplazamiento de fluidos y se determinó la masa seca en un horno a 70 ºC por 72 horas. La densidad de madera secalculó como la proporción de masa entre volumen. La densidad de madera varió significativamente entre las especies, siendo la mayor Gymnanthes lucida Sw., con 0.85 g/cm3 y la menor Bursera simaruba (L.) Sarg, con 0.37 g/cm3. El análisis de regresión demostró que 20 de 23 especies presentaron una relación positiva entre la densidad de madera y el tamaño diamétrico. Se concluyó que la densidad de la madera varia por especies y tamaño diamétrico del árbol en estos ecosistemas forestales. Los resultados son útiles para modelar la dinámica de acumulación de biomasa arbórea de la vegetación primaria y secundaria que se encuentra enconstantes cambios en su estructura y composición de especies.
Metaphorical Analysis of pre-service early childhood teachers' Perceptions of Parent and Parent-Child Relationships
Authors:   The Association of Korea Counseling Psychology Education Welfare, KIM Jung-Min , CHOI Ji-Hyun
Published: January 2023

This study conducted a metaphorical analysis of the parent-parent-child relationship targeting3rd graders in the early childhood education department. As a result, pre-primary earlychildhood teachers regard their parents as 'parents as emotional supporters', 'parents as victims','parents as absolute beings with strength', 'parents as guardians', 'parents in the process ofself-growth', 'guides of life' Parents as 'parents' and 'parents as examples of life' were recognized in that order. In addition, parent-child relationships were recognized in the order of'essential relationship', 'symbiotic relationship', 'equality relationship', 'trust relationship','relationship where love and hate coexist', and 'relationship that grows together' was doingThrough this, it will be an opportunity to derive the operational direction of parenteducation-related subjects opened in the early childhood teacher training course. In the future,effective parent education will be achieved by forming a trusting relationship between parentsand teachers.
A Study on the Teaching Practice Experience of Preservice School Counselor: A Phenomenological Approach
Authors:   The Association of Korea Counseling Psychology Education Welfare, KIM Sinae
Published: January 2023

The purpose of this study is to reveal the meaning of the teaching practice experience inundergraduate students majoring in counseling. The researcher conducted in-depth interviewswith six undergraduate students majoring in counseling who participated in teaching practice inBusan and Gyeongnam from July 19, 2022, to August 31, 2022, and analyzed the collected datausing Giorgi(1985)'s phenomenological research method. As a result of the analysis, 7components and 18 sub-components were derived. Seven main components are ‘experiencingexcitement, anticipation, tension, and anxiety ahead of the practice’, ‘preparing and workinghard for the practice’, ‘experiencing dissatisfaction with the content of teaching practice’, ‘gettingto know students' negative perceptions of counseling’, ‘becoming more accepting of students’,‘strengthening of career identity’. Based on the results of this study, the researcher madesuggestions for follow-up research and implications to consider in relation to the teachingpractice of professional school counselors.
Pengembangan Media Articulate Storyline Berbasis Problem Solving untuk Meningkatkan Kemampuan Pemecahan Masalah Siswa SMP pada Materi Tekanan Zat
Authors: Ratnasari Erma , Syahmani Syahmani , Hafizah Ellyna
Published: January 2023

Penelitian ini dilatarbelakangi oleh rendahnya kemampuan pemecahan masalah siswa. Penelitian ini bertujuan untuk menghasilkan media pembelajaran articulate storyline berbasis problem solving pada materi tekanan zat yang valid dan praktis sehingga layak digunakan dalam kegiatan pembelajaran. Model yang digunakan dalam pengembangan ini adalah model ADDIE (analyze, design, development, implementation, evaluation). Instrumen pengumpulan data yang digunakan yaitu lembar validasi media, lembar validasi soal, angket keterbacaan dan angket respon siswa. Hasil validasi media dan soal dihitung menggunakan persamaan rumus Aiken’s V dan memperoleh nilai berturut-turut sebesar 0,85 dan 0,84 dengan kriteria validitas tinggi serta  percentage of agreement dihitung menggunakan persamaan rumus menurut Borich dan memperoleh nilai berturut-turut sebesar 84,30% dan 88,90% dengan kriteria konsisten dan sangat konsisten. Hasil kepraktisan media articulate storyline berbasis problem solving ditinjau dari angket keterbacaan dan angket respon siswa, memperoleh nilai berturut-turut sebesar 94,50% dan 93,60% dengan kriteria sangat praktis. Maka dapat disimpulkan bahwa media articulate storyline berbasis problem solving layak digunakan dalam pembelajaran materi tekanan zat.
Pengembangan Media Pembelajaran Interaktif Articulate Storyline pada Materi Sistem Tata Surya untuk Kelas VII SMP/MTs
Authors: Saskia Reski Anna , Ajizah Aulia , Hafizah Ellyna
Published: January 2023

Terbatasnya media pembelajaran yang digunakan pada materi sistem tata surya dan hanya berpatok pada buku paket menyebabkan menyebabkan peserta didik kurang mampu menerapkan konsep pembelajaran. Dilakukan penelitian dan pengembangan media pembelajaran Articulate Storyline materi sistem tata surya untuk kelas VII SMP/MTs. Penelitian ini bertujuan untuk mendeskripsikan validitas dan kepratisan media interaktif yang menggunakan software articulate storyline. Metode pengembangan yang digunakan adalah Research and development (R&D) menggunakan model pengembangan Thigarajan, Semmel, & Semmel yaitu 4-D yang memiliki tahapan yakni Define, Design, Develop and Disseminate. Instrumen pengumpulan data menggunakan lembar validasi ahli dan angket respon peserta didik. Teknik analisis data menggunakan uji validitas Aiken’s V dan persentase. Berdasarkan hasil penelitian media pembelajaran interaktif Articulate Storyline memperoleh skor validitas oleh ahli sebesar 0.87 dengan kategori sangat valid. Hasil respon peserta didik memperoleh skor sebesar 88,15% dengan kategori sangat praktis. Dari hasil tersebut maka dikatakan bahwa media pembelajaran interaktif Articulate Storyline layak dan praktis digunakan untuk pembelajaran IPA Kelas VII SMP/MTs. Peneliti berkeyakinan bahwa media pembelajaran yang dikembangkan ini dapat memfasilitasi guru dalam proses pembelajaran dan diharapkan dengan adanya media yang dikembangkan dapat membantu peserta didik lebih mudah memahami dan menguasai pembelajaran IPA terpadu, khususnya pada materi sistem tata surya.
Hub and Distribution Center Location for a Third-Party Logistics service Provider: A Case Study at Tehran
Authors: HASANPOUR JESRİ Zahra Sadat , POURMOHAMMADREZA Nima , FARNİA Seyed Farbod , HASANPOUR JESRİ Seyed Omid
Published: January 2023

The rapid growth of the transportation industry and the advance of the e-commerce have opened opportunities for boom delivery services companies. Although, intense competition between shipping companies has obliged many to amend their shipment networks. In this setting, we aim to provide high-quality shipping services for a third-party logistics company in Iran. Currently, in the selected company, one hub is in the west part of Tehran that gives services to all customers. There are some difficulties in shipping services to the eastern part of Tehran city. Therefore, in this paper, we find the location of another hub center to streamline the shipping process. Moreover, to promote our service levels, some Distribution Centers (DCs) are going to be set up. Due to the lack of shipment data like pick up and delivery data, we tried to find the locations of the hub and the DCs based on Tehran population's data. We clustered 122 regions of Tehran based on population, economic index, accessibility to the internet, and the number of business units. Since some remote regions (which are not in the same vicinity) belong to the same cluster, we defined a relative distance criterion to avoid making remote regions in the same cluster. In each cluster, a fixed or movable DC can be set up to service the regions of its cluster. Moreover, to find the best candidate locations for the hub, each zone of Tehran was assessed based on some criteria like land cost, accessibility to the highways, and distance to its nearest bus terminal. Based on these criteria, some zones have been dominated by others, and the remains were considered as candidate locations in a hub location model. By considering the DCs as spokes in a hub and spoke model, the optimal location for the eastern hub establishment was determined.
IDENTIFICATION OF FACTORS RELATED TO TRANSPORT ENTREPRENEURSHIP INFLUENCING THE ECONOMIC DEVELOPMENT OF UKRAINE
Authors: RIEPINA Inna , LIGONENKO Larysa , SADOVNYK Oleksandr , DZYUBENKO Lyubov , KOVTUN Vita
Published: January 2023

The integration of Ukraine’s economy into the European space requires the dynamic and balanced development of all its sectors, especially the transport sector. The purpose of the research is to identify the factors related to transport entrepreneurship that affect the economic development of Ukraine, in particular regarding the formation of added value (gross regional product). The paper presents the author’s definition of transport entrepreneurship as an independent, systematic, and risky entrepreneurial activity in providing transport services. The results revealed a negative trend in the formation of the added value of the transport enterprises of Ukraine, both in terms of value and as a percentage of GDP. This prompted the authors to determine the factors affecting the formation of gross added value (gross regional product) by transport enterprises of Ukraine to further develop proposals aimed at their activation. Four models were created in the first stage of the research to achieve the goal. These models are based on gross regional product in transport, warehousing, postal and courier activities; gross regional product in transport, warehousing, and postal and courier activities per capita; gross value added in transport, warehousing, and postal and courier activities; and gross value added in transport, warehousing, and postal and courier activities per capita. In the second stage of the research, the fifth model with the highest correlation coefficients was built, which made it possible to identify the factors of negative and positive influence on the formation of gross added value (gross regional product) by transport enterprises in Ukraine. Based on the results, a number of measures are proposed to stimulate factors of positive influence and neutralize negative influence. The proposed tools for identifying the factors related to transport entrepreneurship that affect the economic development of Ukraine can serve as markers for the formation of the country’s post-war strategy in the field of transport entrepreneurship.
Historia de un concurso: el caso de Le Corbusier y el Palacio de los Soviets de Moscú = History of a competition: The case of Le Corbusier and the Palace of the Soviets in Moscow
Authors: Ponce Gregorio Pedro , Peris Blat Ignacio , Sanchis Gisbert Salvador José
Published: January 2023

AbstractBetween 1931 and 1935, the competition for the Palace of the Soviets in Moscow was undoubtedly one of the most important architectural events of the 20th century. It brought together some of the most influential European architects of the time, such as Le Corbusier, E. Mendelsohn, W. Gropius and H. Poelzig, together with other important names of the Soviet scene, such as the famous Vesnin brothers, I. Zholtovsky, V. Shchuko and B. Iofan. Iofan. The competition, decided in favour of a group of Soviet architects led by Iofan himself, led to a series of opposing reactions led by Le Corbusier. From there, our goal will be none other than to recover some of these important works in order to put them in relation and try to contextualize the harsh reactions of European architects against the contest result.ResumenEntre 1931 y 1935 el concurso para el Palacio de los Soviets de Moscú fue, sin lugar a dudas, uno de los eventos arquitectónicos más importantes del siglo XX. En él se dieron cita algunos de los arquitectos europeos más influyentes del momento, como es el caso de Le Corbusier, E. Mendelsohn, W. Gropius y H. Poelzig; junto a otros importantes nombres del panorama soviético, como los célebres hermanos Vesnin, I. Zholtovsky, V. Shchuko y B. Iofan. El concurso, resuelto en favor de un grupo de arquitectos soviéticos encabezados por el propio Iofan, derivó en toda una serie de reacciones contrarias lideradas por Le Corbusier. A partir de ahí, nuestro objetivo no será otro que el de recuperar algunos de estos importantes trabajos para así ponerlos en relación y tratar de contextualizar las duras reacciones de los arquitectos europeos contra el resultado del concurso.
Los acuartelamientos de la Guardia Civil proyectados por arquitectas. Revisión de sus contribuciones en los últimos cincuenta años = Civil guard barracks designed by women architects. A review of their contributions over the last fifty years
Authors: Pinzón‑Ayala Daniel
Published: January 2023

ResumenLas casas cuartel de la Guardia Civil conforman un heterogéneo conjunto de arquitecturas híbridas, en donde confluyen espacios laborales y residenciales. Su formalización tipológica por parte de la Institución no se efectuaría de manera decidida y continuada hasta la Segun-da República. En ese proceso, que continúa hasta la actualidad, ha participado un nutrido y, en gran medida desconocido, grupo de arquitectos, ingenieros militares y aparejadores, con una presencia reducida de arquitectas. A pesar de esa menor cuantía, su participación también es digna de ser reseñable, ya que en estos últimos cincuenta años también han con-tribuido a la evolución y modernización de las casas cuartel como tipología militar única en nuestro país. Por este motivo, en este artículo se pone el foco en una serie de arquitectas, en sus proyectos y en sus aportaciones, acorde con cada periodo histórico y con la propia infor-mación facilitada por ellas.AbstractThe barracks of the Civil Guard are a heterogeneous group of hybrid architectures, where work and residential spaces converge. Their typological formalisation by the institution did not take place in a decisive and continuous manner until the Second Republic. In this process, which continues to the present day, a large and largely unknown group of architects, military engineers and quantity surveyors took part, with a reduced presence of women architects. Despite this smaller number, their participation is also worthy of note, as over the last fifty years they have also contributed to the evolution and modernisation of the barracks houses as a unique military typology in our country. For this reason, this article focuses on a series of women architects, their projects and their contributions, in accordance with each historical period and with the information provided by them.
Statistical particle in cell for solving the phonon Boltzmann equation
Authors: Volkov Yuri Aleksandrovich , Markov Mikhail Borisovich , Tarakanov Ilya Alekseyevich
Published: January 2023

The propagation of heat in a crystal is considered as a process of transport of phonons – quasi-particles with quasi-momentum and energy. The Boltzmann kinetic equation is constructed for the phonon’s distribution function in the phase space. The scattering of phonons is modeled in the approximation of the time of relaxation of their distribution to the equilibrium state. The numerical algorithm for solving the kinetic equation is based on the statistical method of particles, which combines the solution of the phonons motion equations with stochastic modeling of their creation and annihilation. The results of the numerical solution of the problems of temperature relaxation in a crystal during heating of its surface and energy release in the volume are considered.
Construction of relativistic hydrodynamics of a multicomponent fluid. 1. The method of relativistic irreversible thermodynamics
Authors: Kolesnichenko Aleksandr Vladimirovich
Published: January 2023

The paper develops relativistic mechanics and irreversible thermodynamics of a cosmological liquid mixture in which thermal conduction, diffusion, viscous flow and their crossing phenomena can occur. The main thermodynamic fields that occur in relativistic irreversible thermodynamics are defined as statistical expressions using relativistic kinetics. The effects of the Eckart approach on the choice of the hydrodynamic velocity are shown. The equations of relativistic multicomponent hydrodynamics for local densities of momentum, energy and number of particles of different sort, are also obtained from the fundamental conservation laws of relativistic thermodynamics.. The energy conservation law (the first beginning of relativistic thermodynamics) is formulated. Covariant Gibbs relation and local form of the second principle of thermodynamics in the presence of entropy source were derived in order to obtain determining relations linearly connecting fluxes with corresponding thermodynamic forces. Equivalent forms of relativistic entropy production in the form of a bilinear expression in terms of thermodynamic forces were obtained. A new cross-effect between diffusion and conduction arising from the relativistic term in the thermodynamic force coupled to the heat flux is discussed. The synopsis presented is of interest for relativistic mechanics, astrophysics, and cosmology.
Constructing relativistic hydrodynamics of a simple fluid in a class of second-order theories. 2. The method of relativistic extended irreversible thermodynamics
Authors: Kolesnichenko Aleksandr Vladimirovich
Published: January 2023

In this paper we constructed thermo-hydrodynamics for relativistic fluid (taking into account the second order of deviation from equilibrium for dissipative heat and viscosity flows) on the basis of extended irreversible thermodynamics (RNT). RNT formalism, providing adequate modeling of systems close to the equilibrium state, goes beyond the local equilibrium hypothesis by expanding the number of basic independent variables (including dissipative flows), as well as by modifying such conceptual concepts as entropy, temperature and pressure. The evolutionary laws for the main nonequilibrium field quantities of the relativistic system are postulated: 4-vector particle flux, 4-vector energy-momentum and 4-vector entropy flux. In order to derive the constitutive equations, a nonlocal Gibbs covariance relation and a nonlocal form of the second principle of thermodynamics with a source of entropy due to additional variables-dissipative flows-were obtained. The defining equations of the hyperbolic type, forbidding superluminal velocities, modified by relaxation terms, have been obtained. The construction of relativistic thermodynamics is carried out using the hydrodynamic 4-speed defined by Eckart. The constructed relativistic hydrodynamics has its applications in such important fields of science as nuclear physics, astrophysics and cosmology.
Implementation Of The Material Incentives Mechanism In A Healthcare Organization With The Use Of HIS
Authors:   Federal V. A. Nasonova Research Institute of Rheumatology of Russian Academy of Medical Sciences, Mantserov K. M. , Khatkevich M. I. ,   Federal Ailamazyan А. К. Program Systems Institute of Russian Academy of Sciences, Khatkevich M. M. ,   Federal Ailamazyan А. К. Program Systems Institute of Russian Academy of Sciences, Shipilova A. V. ,   Federal V. A. Nasonova Research Institute of Rheumatology of Russian Academy of Medical Sciences
Published: January 2023

The article notes the importance of the financial incentive mechanism for a healthcare organization. The mechanism should be both effective, delicate, objective, fair, transparent, stimulating professional and personal growth. The principles are proposed and the mechanism of material incentives, built at the V. A. Nasonova Research Institute of Rheumatology. The features of the implementation of the subsystem “Incentive payments” in HIS Interin PROMIS are briefly presented. In conclusion, the main results of the implementation and operation of the subsystem “Incentive payments” of HIS in the medical organization are listed.
Development of patient-centered services in medical organizations
Authors:   Ailamazyan Program system institute of RAS, Kazakov I. F. , Guliev Y. I. ,   Ailamazyan Program system institute of RAS, Belchenkov A. A. ,   INTERIN Group of companies, Rudetsky S. V. ,   Ailamazyan Program system institute of RAS
Published: January 2023

The development of patient-oriented means of interaction between citizens and organizations of the participants of the modern “digital interaction” system is a current trend in the field of medical information technology. The formed principles of digital transformation of healthcare, which are carried out within the framework of the federal project “Creation of a unified digital contour in healthcare based on the unified state health information system (UGISZ) ”. National Project “Health Care”, provide ample opportunities for designing and developing new applied solutions in terms of requests from medical organizations for modern domestic IT tools for “communication” with patients. The aim of the article is to analyze and describe the current level of development of patient-oriented software products and methods of their development. As a result, the software “Personal account of the patient “Interin LC”, developed on the basis of research and running on a stack of freely distributed software, is described.
Factores predictores de anastomosis colónica en cirugía de emergencia en el Hospital Emergencias José Casimiro Ulloa
Authors:   , Diez Noblecilla Héctor Enrique
Published: January 2023

Se calculo que en el 2020 aproximadamente 8.1 millones de personas murieron a causa de lesiones y accidentes de transito. El trauma es la tercera causa de discapacidad a nivel mundial. El trauma representa la principal pérdida de la fuerza laboral debido a la morbilidad y mortalidad asociadas. Alrededor de 671 mil millones de dólares se invierten en personas victimas de trauma en Norte América y cerca de 214 mil millones de dólares se priorizan en las lesiones causadas por dichos traumas. Existen multiples desafios para el manejo del trauma a nivel mundial. La tendencia ascendente observada de las lesiones, se ha relacionado con mala infraestructura y urbanización. Los sistemas de emergencia subdesarrollados para cuidar las víctimas amplifican aún más la magnitud del problema porque no hay equipos de respuesta bien establecidos en la mayoría de los lugares. En los países desarrollados, se tienen mejores resultados debido a los costosos centros de atención de trauma con equipos multidisciplinares que atienden a las víctimas. A pesar de los avances tecnológicos y la mejora de las habilidades quirúrgicas, la incidencia de fuga anastomótica intestinal después de una cirugía gastrointestinal varía entre el 3 y el 20% con una tasa de mortalidad del 10-15%. La dehiscencia de anastomosis representa la complicación más espantosa dentro de las cirugías de emergencia y se relaciona con aspectos de morbilidad y mortalidad importante. La etiología es multifactorial, pero se considera que la perfusión sanguínea insuficiente juega un papel determinante en la patogenia.
La calidad de servicio y su relación con las habilidades blandas de los vendedores de la empresa Detecin SAC - Lima 2020
Authors:   , Chinchay Montaldo Vanessa Mercedes
Published: January 2023

A través del presente estudio se busca determinar cómo se desarrolla la relación entre la calidad de servicio y las habilidades blandas de los vendedores de la empresa Detecin S.A.C. ubicada en Lima, Perú, empleando un diseño no experimental cuantitativo y de corte transversal correlacional, usando una muestra poblacional de 109 encuestados. Los instrumentos metodológicos permitieron medir la calidad del servicio y las habilidades blandas de la organización, donde la confiabilidad fue medida por el Alfa de Cronbach, dando como resultado para calidad de servicios un valor de 0,76 y para habilidades blandas un valor de 0,82; lo cual indica que el instrumento ha sido confiable. De esta manera, los resultados del presente estudio lograron evidenciar, mediante un coeficiente de 0,841, que la calidad de servicio presenta una correlación positiva con las habilidades blandas, ya que el incremento de una variable favorece el desempeño incremental de la otra. Como conclusión general, se encontró una relación de dependencia entre las competencias de los vendedores y la calidad de servicio de la compañía Detecin S.A.C. y se espera que esta investigación impulse la mejora de las relaciones entre los vendedores y clientes; la satisfacción y fidelización de estos últimos; afianzar las barreras de entrada; reducir costos de recuperación de clientes; e incrementar las ventas mediante el desarrollo de habilidades blandas del personal mencionado.
DNA-bridging by an archaeal histone variant via a unique tetramerisation interface
Authors: Ofer Sapir , Blombach Fabian , Erkelens Amanda , Barker Declan , Schwab Samuel , Smollett Katherine , Matelska Dorota , Fouqueau Thomas , Vis Nico van der , Kent Nicholas , Dame Remus , Werner Finn
Published: January 2023

In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B that assemble into octameric nucleosome particles. Archaeal histones are dimeric and assemble on DNA into ‘hypernucleosome’ particles of varying sizes with each dimer wrapping 30 bp of DNA. These are composed of canonical and variant histone paralogues, but the function of these variants is poorly understood. Here, we characterise the structure and function of the histone paralogue MJ1647 from Methanocaldococcus jannaschii that has a unique C-terminal extension enabling MJ1647 homotetramerisation. The 1.9 Å X-ray structure of a dimeric MJ1647 species, structural modelling of the tetramer, and site-directed mutagenesis reveal that the C-terminal tetramerization module consists of two alpha helices in a handshake arrangement. Unlike canonical histones like M. jannaschii A3, MJ1647 tetramers can bridge two DNA molecules in vitro. Using single-molecule tethered particle motion and DNA binding assays, we show that MJ1647 tetramers bind ~60 bp DNA and compacts DNA in a highly cooperative manner. We furthermore show that MJ1647 effectively competes with the transcription machinery to block access to the promoter in vitro. Our results reveal MJ1647 as the first histone with DNA bridging properties, which has important implications for genome structure and gene expression in archaea.
Quantum Variational Rewinding for Time Series Anomaly Detection
Authors: Baker Jack , Horowitz Haim , Radha Santosh , Fernandes Stenio , Jones Colin , Noorani Noorain , Skavysh Vladimir , Lamontagne Philippe , Sanders Barry
Published: January 2023

Electron dynamics, financial markets and nuclear fission reactors, though seemingly unrelated, all produce observable characteristics evolving with time. Within this broad scope, departures from normal temporal behavior range from academically interesting to potentially catastrophic. New algorithms for time series anomaly detection (TAD) are therefore certainly in demand. With the advent of newly accessible quantum processing units (QPUs), exploring a quantum approach to TAD is now relevant and is the topic of this work. Our approach - Quantum Variational Rewinding, or, QVR - trains a family of parameterized unitary time-devolution operators to cluster normal time series instances encoded within quantum states. Unseen time series are assigned an anomaly score based upon their distance from the cluster center, which, beyond a given threshold, classifies anomalous behaviour. After a first demonstration with a simple and didactic case, QVR is used to study the real problem of identifying anomalous behavior in cryptocurrency market data. Finally, multivariate time series from the cryptocurrency use case are studied using IBM’s Falcon r5.11H family of superconducting transmon QPUs, where anomaly score errors resulting from hardware noise are shown to be reducible by as much as 20% using advanced error mitigation techniques.
Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression
Authors: Park Jong Ho , Mortaja Mahsa , Son Heehwa , Azin Marjan , Wang Jun , Collier Michael , Mandinova Anna , Semenov Yevgeniy , Mino-Kenudson Mari , Demehri Shadmehr
Published: January 2023

Chronic inflammation is a major cause of cancer worldwide. Interleukin 33 (IL-33) is a critical initiator of cancer-prone chronic inflammation; however, its induction mechanism by the environmental causes of chronic inflammation is unknown. Herein, we demonstrate that Toll-like receptor (TLR)3/4-TBK1-IRF3 pathway activation links environmental insults to IL-33 induction in the skin and pancreas. FDA-approved drug library screen identified pitavastatin as an effective IL-33 inhibitor by blocking TBK1 membrane recruitment/activation through the mevalonate pathway inhibition. Accordingly, pitavastatin prevented chronic pancreatitis and its cancer sequela in an IL-33-dependent manner. IRF3-IL-33 axis was highly active in chronic pancreatitis and its associated pancreatic cancer in humans. Interestingly, pitavastatin use correlated with a significantly reduced risk of chronic pancreatitis and pancreatic cancer in patients. Our findings demonstrate that blocking the TBK1-IRF3 signaling pathway suppresses IL-33 expression and cancer-prone chronic inflammation. Statins present a safe and effective therapeutic strategy to prevent chronic inflammation and its cancer sequela.
Concurrent assessment on blood lead in young children and toy lead in Shanghai
Authors: Peng Jiayu , Gao Zhenyan , Xu Jian , Lin Yanfen , Specht Aaron J , Chen Shuwen , Nie Linda H , Huang Linhua , Yan Chonghuai
Published: January 2023

Since toys are the potential sources of lead contamination for young children, we aim to compare blood lead levels (BLLs) of young children and lead-levels in toys played by the children. A total of 2249 children under 7 years old were investigated using stratified cluster sampling in 6 districts of Shanghai, their parents completed questionnaires and children’s whole blood was collected, and then BLLs were measured using tungsten atomizer absorption spectrophotometer. At the same time, 294 toys from the 6 supermarkets/ toy-stores located in the surrounding 5 districts were collected using stratified cluster sampling and lead levels in toys were measured by a portable X-ray Fluorescence instrument. The geometric mean of the BLLs was 2.02 μg/dL. After adjusting for related confounders, playing with plastic toys is a significant risk factor (β=0.067, P =0.019) for BLL-increment. Plastic toys accounted for the highest proportion (156/294, 53.06%) among the studied toys and had the highest average lead level (39.13 ppm). In the 3 districts where children’s BLLs and toys’ lead levels were both measured, the districts with higher toy lead levels had higher children’s BLLs (the average toy lead levels in Pudong-suburban vs. Xuhui vs. Yangpu supermarkets/ toy-stores: 24.62 vs. 0 vs. 15.43 ppm, P<0.01; the medians of BLLs in Pudong-suburban vs. Xuhui vs. Yangpu children: 2.07 vs. 1.55 vs. 1.50 μg/dL, P<0.001). Lead levels in toys may be associated with the BLLs of young children, and lead contamination in plastic toys need cautions for preventing young children from potential lead exposure.
Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved Drug
Authors: Sadek Hesham , Wang Ping , Ahmed Mahmoud , Nguyen Ngoc Uyen Nhi , Menendez-Montes Ivan , Farag Ayman , Thet Suwannee , Hsu Ching-Cheng , Elhelaly Waleed , Lam Nicholas , Wansapura Janaka , MA NIGN , Zhou Shane , Zhang Tiejun , Singh Rohit , Sadayappan Sakthivel , Wu Joseph
Published: January 2023

Dilated cardiomyopathy (DCM), which results from genetic disorders resulting in decreased myocardial contractility, is a leading cause of morbidity and mortality worldwide. There are several therapeutic challenges in treating DCM, which include poor understanding of the underlying mechanism of impaired myocardial contractility, and the difficulty of developing targeted therapies to reverse mutation-specific pathologies. The long, treacherous, and expensive path to new drug development, coupled with the rarity of individual mutations underscore the difficulties of drug development for DCMs. In the current report we focused on K210del, a DCM-causing mutation, which was identified over 20 years ago. This mutation is a three-nucleotide deletion of sarcomeric troponin T (TnnT), resulting in loss of lysine 210. Here we present the crystal structure of the troponin complex carrying the K210del mutation. We found that K210del leads to an allosteric shift in the troponin complex resulting in distortion of activation Ca2+ binding domain of TnnC at S69, thereby resulting in calcium discoordination. Next, we adopted an in-silico approach to identify FDA approved drugs that may correct the structure of the mutant troponin complex, which led us to identify the bisphosphonate risedronate as a potential structural corrector. Co-crystallization of risedronate with the mutant troponin complex restored of the normal configuration of S69 and calcium coordination. At a phenotypic level, risedronate normalized force generation in iPSC-derived cardiomyocytes from a patient carrying the mutation, and restored calcium sensitivity in skinned papillary muscles isolated from K210del mutant mice. Importantly, systemic administration of risedronate to K210del mutant mice normalized left ventricular ejection fraction (LVEF) as determined by echocardiography and MRI. Collectively, these results identify the structural basis for decreased calcium sensitivity in K210del and highlight a path to structural and phenotypic correction as a potential therapeutic strategy in genetic cardiomyopathies.
Treatment effects of two pedicle screws techniques strengthened by bone cement on old patients suffering from osteoporosis and lumbar spinal stenosis
Authors: Pan Wei , Jian Yuekui , He Jinming , Liang Liang
Published: January 2023

OBJECTIVE:To compare treatment effects of pedicle screws techniques strengthened by polymethyl methacrylate (PMMA) bone cement and injectable calcium sulfate cement (CSC) on old patients suffering from osteoporosis and lumbar spinal stenosis.
MATERIALS AND METHODS: One hundred and twenty-four cases are selected and they are divided into PMMA bone cement group with 58 cases and injectable CSC group with
66 cases in order to compare and analyze treatment effects of two groups.
RESULTS: Operation time and total dose of bone cement in CSC group are obviously lower than those in PMMA group and there are no differences regarding bleeding volume between two groups. Visual analog scale in two groups is gradually decreasing. For CSC group, scores at 1 day and 1 week after operation are obviously lower than those in PMMA group and there are no differences regarding this after 1 month. In PMMA group, bone mineral density values are not improved with time while it is increasing gradually in CSC group; differences between groups are of statistical significance (P
< 0.05). Oswestry Disability Indices in two groups after treatment are all decreasing while Japanese Orthopedic Association (JOA) scores are increasing, especially in CSC group, differences are of statistical significance (P < 0.05); effective rate of improvement in CSC group is higher than that in PMMA group, however, as for ranked data, there are no statistical significance. Both groups have good imaging evaluation.
CONCLUSIONS: Injectable CSC has better clinical effects than pedicle screws technique strengthened by PMMA bone cement in terms of treating old patients suffering from osteoporosis and lumbar spinal stenosis.
Genomic-oriented Multi-level Regulatory Landscape of Renal Tumor Metastasis- Related Key Genes
Authors: Zhou Bin , Wang Haiyan , Liu Bo , wang Zhe , zhou Guixia , Zhao Tingting , Du Chunlei , Hu Changdong , Li Xiangping , Ban Bo , Guo Rui
Published: January 2023

Metastasis of renal tumor leads to poor prognosis of patients and increased therapeutic challenges. Nevertheless, the molecular mechanism underlying this clinical phenomenon remain to be elucidated. In this study, we identified 81 metastasis-related key genes and systematically explored their regulatory axis in renal tumor metastasis. In detail, both copy number variation and DNA methylation can partially affect the expressions of these key genes and showed differential distribution in the metastatic group. Path analysis modeling evaluated the potential overall causal effects from genomic level to phenotype and determined five statistical models. Additionally, the competing endogenous network revealed the post-transcriptional regulation of these key genes. Besides that, immune cell infiltration analyses suggested that some key genes may be involve in the regulation of tumor immunologic microenvironment. Furthermore, we built an effective machine learning model to predict renal tumor metastasis for clinical application. In summary, our research systematically described the potential biological roles and regulatory profiles of renal tumor metastasis-related genes, which may contribute to the improvement of clinical targeted therapy for renal tumor.
Optimized Multi-Objective Segnet With Deep Residual Network For Prostate Cancer Segmentation And Detection
Authors: Reddy Siva Kumar , Kathirvelu Kalaivani
Published: January 2023

The authors have requested that this preprint be removed from Research Square.
Uncovering the biocontrol mechanism of Bacillus subtilis YPS-32 antagonism of Streptomyces scabies infection through transcriptome and proteome analysis
Authors: Zhou Yingjun , li qing , Peng Zheng , Li Jianghua , Zhang Juan
Published: January 2023

Background
The bacterium Streptomyces scabies is the main pathogen causing potato common scab. Efforts to control S. scabies infection using the bacterial strain Bacillus subtilis YPS-32 as a biocontrol agent have been excellent; however, the underlying biocontrol mechanism is not clear.
Results
In this study, we first determined the key time points of B. subtilis YPS-32 inhibition of S. scabiesgrowth by analyzing the interaction of the two bacterial species in co-culture. We then analyzed differential changes in gene and protein expression patterns in B. subtilis YPS-32 after 0 h (control) and 24 h (peak inhibition) co-culture, using transcriptomic and proteomic sequencing, respectively. We found that the expression levels of genes and proteins related to the synthesis of the antimicrobial metabolites fengycin, bacillaene, and bacilysin were significantly up-regulated in B. subtilis YPS-32 after 24 h co-culture. In addition, the protein, WP_003245811.1 related to bacillibactinexport was also upregulated in co-culture.
Conclusions
The fengycin, bacillaene, bacilysin and bacillibactin were potential antibacterial metabolites of B. subtilis YPS-32.This research will provide support for the further molecular mechanism research of B. subtilis YPS-32 metabolites.
Acid-driven immune suppression by pHLIP-fused PD-L1 under inflammatory conditions
Authors: Chen Guojiang , Zheng Hang , Zhang Yuting , Wu Haiyan , Feng Junjuan , Sun Ying , Zhang Min , Xiao He , Qiao Chunxia , Wang Jing , Luo Longlong , Li Xinying , Feng Jiannan , Zheng Yuanqiang , Wang Yi , Shi Yanchun
Published: January 2023

Programmed cell death–ligand 1 (PD-L1)/PD-1 axis is crucial for maintenance of immune homeostasis and its impairment partially accounts for the pathogenesis of inflammatory diseases. Hence, augmenting PD-L1/PD-1 signals represents a novel strategy to prevent destructive inflammation and induce immune tolerance. Recently, we developed a new cargo by conjugating the ectodomain of PD-L1 with pHLIP, a low pH-responding and membrane-inserting peptide, and demonstrated its potent immune-suppressive activity under acidic conditions in vitro. Herein, we further showed that PD-L1-pHLIP well responded to relatively high acidic buffer, while it could not inhibit T cell expansion in weakly acidic solutions. Furthermore, in a mouse model of acute intestinal inflammation, PD-L1-pHLIP treatment prolonged survival time and attenuated colitis in mice subjected to 6% dextran sulfate sodium (DSS) instead of 3% DSS. The different efficacy was due to the distinct acidity in the lesions, which facilitated PD-L1-pHLIP accumulation in the niche of 6% DSS-triggered severe inflammation. Mechanistic investigations revealed that PD-L1-pHLIP inhibited the release of proinflammatory cytokines in infiltrating macrophages and other immune cells in a PD-1-dependent and/or –independent fashion. Taken together, this study highlights PD-L1-pHLIP as a novel therapeutic avenue for inflammatory diseases.
Autophagy-related genes and pathways was associated with osteoarthritis pathogenesis
Authors: Guan Taiyuan , Guo Yang , Wu Chengjie , Niu Yuanyuan , Xiao Jirimutu , Ma Yong
Published: January 2023

Background: Patients with osteoarthritis have musculoskeletal-related chronic disability, leading to the high pain intensity. Explaining the molecular mechanisms of osteoarthritis is critial for the diagnosis and cure. Therefore, This research aimed to find key candidate genes involved in osteoarthritis pathogenesis.
Methods: We identified differentially expressed genes by integrating multiple microarry datasets in cartilage (GSE43923, GSE113825, GSE129147 and GSE169077). Functional enrichment analysis and protein-protein interaction analysis were performed.
Results: We identified sixty-six significantly expression genes (56 up-regulated and 10 down-regulated). Through functional enrichment analysis and protein-protein interaction analysis, we found that the biological process of these genes was enriched in focal adhesion, ECM-receptor interaction and PI3K-Akt signaling, which were closely related with autophagy. Moreover, ceRNA network showed that thirty-four DEGs, including ECM-receptor interaction-related genes (COL4A1, COL4A2 and COL1A2, LAMB1 an THBS2), exist competing endogenous regulating network mediated by 7 lncRNAs and 8 miRNAs. Furthermore, differentially expressed autophagy-related genes (CCL2, CDKN1A, CXCR4, DAPK1, DLC1, FAS, HSPA8, MYC and SERPINA1) were remarkably identified to interact with multiple of the common DEGs in ECM-receptor interaction and PI3K-Akt signaling pathway, suggesting that autophagy plays important role in osteoarthritis pathogenesis by regulating ECM-receptor interaction and PI3K-Akt signaling pathway.
Conclusions: This multiple transcriptome analysis identifies ECM-receptor interaction and PI3K-Akt signaling pathway related to osteoarthritis pathogenesis by regulating autophagy and participating in ceRNA network.