bluuebunny/crossref_metadata_2025 huggingface dataset:
Asymmetric Effect of Monetary Policy on Housing Price from Short-Term and Long-Term Perspectives
Authors: Zhao Kai , Hao Yi-Bing , Wu Wan-Shu ,   School of Economics, Qingdao University 62 Keda Avenue, Qingdao 266075, China,   School of Statistics, Huaqiao University 668 Jimei Ave, Xiamen 361021, China,   College of Architecture and Urban Planning, Qingdao University of Technology 11 Fushun Road, Qingdao 266033, China
Published: July 2022

This study uses two main monetary policy tools, the real interest rate and M2, to investigate and analyze the correlation between monetary policy tools and housing prices. The sample period runs from 2006 to 2021 and the data frequency is monthly. The analysis explores the effects of the real interest rate and M2 on real estate prices through the integration of short- and long-term perspectives. The findings show that the real interest rate has no asymmetric effect on housing prices in the short term, but has a significant asymmetric effect in the long term. Monetary supply is asymmetric in both the short and long terms. In the short term, monetary supply tools are invalid for adjusting housing prices, while increasing the real interest rate could inhibit the rise in housing prices; in the long term, decreasing the real interest rate and monetary supply could inhibit the rise in housing prices.
Consumo habitual de videojuegos y nivel de atención en escolares de primaria
Authors: Carrillo López Pedro José , García Perujo María
Published: July 2022

En la literatura científica se observa que los videojuegos es un tema aún "inexplorado" en tanto que casi la totalidad de los estudios realizados parten de precomprensiones que impiden el claro conocimiento de los mismos y su posible relación con predictores de salud en población infanto-juvenil. Por ello, el objetivo es analizar la relación existente entre la atención y el consumo habitual de videojuegos en una muestra de escolares de quinto y sexto de Educación Primaria. Se diseñó un estudio descriptivo transversal compuesto con una muestra de 125 escolares. La atención selectiva se evaluó mediante el Test de Percepción de Semejanzas y Diferencias y los hábitos de consumo de videojuegos a través del Cuestionario sobre hábitos de consumo de los videojuegos. El análisis estadístico efectuado no refleja una asociación significativa entre el consumo habitual de videojuegos y la atención (β = -0,442; t = -0,454; p > .005). Sobre la base de estos resultados, se concluye que el consumo habitual de videojuegos no se asocia con la atención en escolares de Educación Primaria. En este sentido, estudios longitudinales y prospectivos deberán determinar el modo en el que la tendencia a poseer un mayor consumo habitual de videojuegos, y/o conductas en relación a esta variable, puedan condicionar la atención de los individuos a lo largo de su escolarización y en periodos vitales posteriores.
Synthesis, Theoretical Study, and Biological Evaluation of Some Metal Ions with Ligand "Methyl -6-[2-(4-Hydroxyphenyl) -2-((1-Phenylethylidene) Amino) Acetamido] -2,2-Dimethyl-5—Oxo-1-Thia-4-Azabicyclo [3.2.0] Heptane-3-Carboxyylate
Authors: Hassan Sahar S. , Kadhim Nafeesa J. , Jaber Zahraa. A.
Published: July 2022

Schiff base (methyl 6-(2- (4-hydroxyphenyl) -2- (1-phenyl ethyl ideneamino) acetamido) -3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate)Co(II), Ni(II), Cu (II), Zn (II), and Hg(II)] ions were employed to make certain complexes. Metal analysis M percent, elemental chemical analysis (C.H.N.S), and other standard physico-chemical methods were used. Magnetic susceptibility, conductometric measurements, FT-IR and UV-visible Spectra were used to identified. Theoretical treatment of the generated complexes in the gas phase was performed using the (hyperchem-8.07) program for molecular mechanics and semi-empirical computations. The (PM3) approach was used to determine the heat of formation (ΔH˚f), binding energy (ΔEb), and total energy (ET) for ligands and metal complexes at 298 ᴼK. To explore the reactive sites of the compounds, the electrostatic potential of the ligand (L) was computed. PM3 was used to calculate the vibrational frequencies of the ligand (L) and its metal complexes, which were then compared to experimental data. The antibacterial activity of (L) and its metal complexes against three harmful microorganisms were examined: Staphylococcus aureus (gram positive), Echerchia coli (gram negative), and Candida albicans.
Synthesis, characterization and bioactivity Study from azo – ligand derived frommethyl-2-amino benzoatewith some metal ions
Authors: Ibraheem Israa H. , Mubder Noora Saad , Abdullah Mays Mohammed , Al-Neshmi Haider
Published: July 2022

A Ligand (ECA) methyl 2-((1-cyano-2-ethoxy-2-oxoethyl)diazenyl)benzoate with metals of (Co2+, Ni2+, Cu2+) were prepared and characterization using H-NMR, atomic absorption spectroscopy, ultra violet (UV) visible, magnetic moments measurements, bioactivity, and Molar conductivity measurements in soluble ethanol. Complexes have been prepared using a general formula which was suggested as [M (ECA)2] Cl2, where M = (Cobalt(II), Nickel(II) and Copper(II), the geometry shape of the complexes is octahedral.
Land use change in Baghdad City and assessment of the Jadriyah and Umm Al- Khanazeer Island Important Bird Area (IBA) from 1984 to 2020
Authors: Fazaa Nadheer A. , Ali Abdulrahman B. , AL-Jabinawi Ahmad JM , Francksen Richard , Whittingham Mark J.
Published: July 2022

Land use change, particularly the expansion of urban areas and associated human activities at the expense of natural and semi-natural areas, is a major ecological issue in urban areas around the world. Climate change being a very strong additional driver for changing the temperature and habitat in the cities. This also applies to Baghdad, Iraq, where urbanisation and climate change exerts a major pressure on the natural habitats of the city, and thus may affect the ability of city planners to adapt to future climate change scenarios. Here we present evidence of substantial growth in urban areas, increases in temperature, and degradation of natural vegetation within Baghdad city by using Remote Sensing techniques and an assessment for the Jadriyah and Umm Al-Khanazeer site (JUKI). These changes were associated with loss of bird species richness within the area, which was previously the only Important Bird Area (IBA) within the city. A standardised scoring system (following Birdlife International global framework) was used to assess Pressure-State-Response:  JUKI site scored 3-5 for pressure (Medium), two for the state (Moderate), and two for the response (Low). Despite the degradation highlighted in Baghdad city, the JUKI site still has 88% intact habitat to support bird trigger species. We conclude that the site urgently needs a detailed management plan to ensure the protection of its habitats and avian fauna, and that the area should be declared as a protected area according to the “IUCN Category IV: Habitat/Species Management Area; to provide a means by which the urban residents may obtain regular contact with nature”, and re-designated JUKI as an IBA site. The study also identifies the most affected areas in the city of Baghdad, which should take the priority of the afforestation efforts and any future restoration campaigns.
Cutaneous small vessel vasculitis associated to palpable purpura after Covid 19 Vaccination: a case report and a literature review
Authors: tirotta daniela , Girelli Francesco , tassinari maurizio , Mazzeo Vincenzo , Muratori Paolo
Published: July 2022

Covid-19 vaccination is mostly safe and effective: adverse events to vaccinations are usually mild and well tolerated. These adverse reactions may include cutaneous reactions and, rarely, cutaneous small vessel vasculitis associated to palpable purpura.We present a case of a small-vessel vasculitis after covid-19 vaccination, that manifested without evidence organ involvement and systemic symptoms, associated to self-resolution, and a review of the cases described in literatureWe have collected the epidemiological and clinical features of these cases.
Effects of cranberry powder on the diversity of microbial communities and quality characteristics of fermented sausage
Authors: Yang Le , Yan Xinlei , Liu Ting , Kang Letian , Gao Xingyu , Sun Yufei , Duan Yan
Published: July 2022

Fermented sausage is popular with many consumers because of its distinctive flavor, but the safety of it has attracted widespread attention. At present, nitrite is widely used in fermented meat products because of its ideal color and bacteriostatic effect, but nitrite can be transformed into nitrosamines, which cause strong carcinogenic effects. Therefore, it is urgent to actively explore safe and efficient nitrite substitutes. In this study, cranberry powder was selected as a natural substitute for nitrite during the production of fermented sausage due to its unique antioxidant and bacteriostatic properties. The results showed that adding an appropriate amount of cranberry powder (5 g/kg) promoted a better color of the fermented sausage and promoted the accumulation of aromatic compounds. Furthermore, Pediococcus and Staphylococcus became the dominant species, accounting for more than 90% in all samples. According to the Pearson correlation analysis, Staphylococcus and Pediococcus had positive effects on the quality characteristics of fermented sausage products. This study provided the latest information on the application of cranberry powder as a natural substitute for nitrite in the process of manufacturing fermented sausage, and it also introduced an advanced solution to improve the quality characteristics and safety of fermented sausage products during processing.
Quantum-Classical Computational Molecular Design of Deuterated High-Efficiency OLED Emitters
Authors: Jones Gavin , Gao Qi , Kobayashi Takao , Sugawara Michihiko , Yamashita Hiroki , Kawaguchi Hideaki , Tanaka Shu , Yamamoto Naoki
Published: July 2022

This study describes a hybrid quantum-classical computational approach for designing synthesizable deuterated Alq3 emitters possessing desirable emission quantum efficiencies (QEs). This design process has been performed on the tris(8-hydroxyquinolinato) ligands typically bound to aluminum in Alq3 and involves optimization of the hydrogen/deuterium (H/D) ratios in these molecules for the discovery of optimally deuterated high-efficiency OLED emitters. It involves a multi-pronged approach which first utilizes classical quantum chemistry to predict the emission QEs of the $Alq_3$ ligands. These initial results were then used as a machine learning dataset for a factorization-machine-based model which was applied to construct an Ising Hamiltonian to predict emission quantum efficiencies on a classical computer. We show that such a factorization machine-based approach can yield accurate property predictions for all 64 deuterated $Alq_3$ emitters with 13 training values. Moreover, another Ising Hamiltonian could be constructed by including synthetic constraints which could be used to perform optimizations on a quantum simulator and device using the variational quantum eigensolver (VQE) and quantum approximate optimization algorithm (QAOA) to discover a molecule possessing the optimal QE and synthetic cost. We observe that both VQE and QAOA can correctly predict the optimal molecule with greater than 0.95 probability on quantum simulators. These probabilities decrease to 0.83 and 0.075 for simulations with VQE and QAOA, respectively, on a quantum device, while the application of the readout error mitigation technique only improves probabilities to 0.90 and 0.084. We have developed the Recursive Probabilistic Variable Elimination (RPVE) method for simulations on noisy devices that recursively eliminates qubits depending on the probability that each qubit possesses a binary value and have demonstrated that RPVE improves the accuracies of VQE and QAOA for predictions of optimal solutions with probabilities of 0.97 on a quantum device.
Research progress on pharmacological actions and molecular mechanisms of Anemoside B4
Authors: Lu Tianming , Wang Qixin , Li Haiyan , Zhao Minghong , Guo Qiuyan , Wang Jigang
Published: July 2022

Anemoside B4 (AB4), as an important ingredient of Chinese herb Pulsatilla Chinensis, has been used in Chinese ancient medicine for thousands of years with exact therapeutic effects of anti-inflammation and anti-tumor. Due to its high potency and low toxicity, AB4 has caused more and more attention of researchers. In this paper, we will first review the clinical usage and fundamental research of AB4 against damaging inflammation of liver, lung, kidney, intestine and joints. Then, we will overview its application and molecular mechanisms in a range of cancers, such as liver cancer, lung cancer, colorectal cancer and cervical cancer. In addition, we pay attention to its pharmacological actions and molecular mechanisms against other diseases, for example, retinal injury, allergic conjunctivitis, pain, vulvovaginal inflammatory disease, acute infectious disease and oral ulcer. Finally, we will discuss the future perspectives of AB4, so as to improve its wide application in clinic.
Can R&D input reduce carbon emissions intensity? Evidence from China
Authors: Zhao Yan , Sun Hui , Xia Xuechao , Ma Dianyuan
Published: July 2022

Climate change caused by greenhouse gas emissions has received widespread attention in recent years. In this paper, panel data of 30 Chinese provinces from 2007 to 2019 are used as research samples to explore research and development input (RDI) on carbon emission intensity (CEI). They are using spatial measurement method, interaction effect model, and mediation effect model, this paper studies whether RDI reduces China's CEI. The empirical results illustrate a positive spatial autocorrelation between RDI and CEI. The spatial agglomeration characteristics of CEI have apparent regional differences. RDI can reduce not only the local CEI, but also the CEI of surrounding areas, and the results are robust. The market and government play an important role in RDI that affects CEI, but there are regional differences. At the same time, RDI can indirectly reduce CEI by promoting industrial upgrading, improving technological innovation, and increasing human capital.
Exosome-shuttled miR-126 mediates ethanol-induced disruption of neural crest cell-placode cell interaction by targeting SDF1
Authors: Li Yihong , Cai Ting , Liu Huina , Lei Yun , Zhang Shun , Sun Fuyu , Liu Jie , Chen Shao-yu , Fan Huadong
Published: July 2022

During embryonic development, two populations of multipotent stem cells, cranial neural crest cells (NCCs) and epibranchial placode cells (PCs), are anatomically adjacent to each other. The coordinated migration of NCCs and PCs plays a major role in the morphogenesis of craniofacial skeletons and cranial nerves. It’s known that ethanol-induced dysfunction of NCCs and PCs is a key contributor to the defects of craniofacial skeletons and cranial nerves implicated in Fetal Alcohol Spectrum Disorder (FASD). However, how ethanol disrupts the coordinated interaction between NCCs and PCs was not elucidated. To fill in this gap, we established a well-designed cell co-culture system to investigate the reciprocal interaction between human NCCs (hNCCs) and human PCs (hPCs), and also monitored the migration behavior of NCCs and PCs in zebrafish embryos. We found that ethanol exposure resulted in a disruption of coordinated hNCCs-hPCs interaction, as well as in zebrafish embryos. Treating hNCCs-hPCs with exosomes derived from ethanol-exposed hNCCs (Exo EtOH ) mimicked ethanol-induced impairment of hNCCs-hPCs interaction. We also observed that a chemoattractant, SDF1, was downregulated in ethanol-treated hPCs and zebrafish embryos. Meanwhile, miR-126 level in Exo EtOH was significantly higher than that in control exosomes (Exo Con ). We further validated that Exo EtOH -encapsulated miR-126 from hNCCs can be transferred to hPCs to suppress SDF1 expression in hPCs. Knockdown of SDF1 replicated ethanol-induced abnormalities either in vitro or in zebrafish embryos. On the contrary, overexpression of SDF1 or inhibiting miR-126 strongly rescued ethanol-induced impairment of hNCCs-hPCs interaction and developmental defects.
Effect of Stirring Speed on Mechanical Properties of the Inorganic-Powder- Reinforced Epoxy Composite
Authors: Mao Lizhou , Yan Xuefeng , Yao Lu , Yu Hang , Cao Haijian , Shen Yue , Ma Yan
Published: July 2022

Inorganic powders (IPs), including SiO2, Al2O3, and Ca3Si3O9, were used as reinforcements and thermosetting epoxy resin was utilized as a matrix to manufacture IP/epoxy preform. The effects of stirring speed on the physical and mechanical properties of IP/epoxy composites were analyzed. Results showed that the tensile, flexural, and impact mechanical properties of IP/epoxy composites generally increased first and then decreased with the rise in stirring speed. They improved by 27.03%, 13.75%, and 8.78% when the stirring speed was 1000 r·min−1. When the stirring speed was less than 1000 r·min−1, the IP was unevenly distributed and prone to agglomeration and had weak junctions, which resulted in poor mechanical properties. When the stirring speed exceeded 1000 r·min−1, the particles with larger sizes were centrifuged, the powder was dispersed unevenly again, and the strength decreased.
Cardiotoxicity’s Differentially Expressed Genes of Tyrosine Kinase Inhibitor---Sorafenib Based on GEO Database
Authors: Yan Jingru , Li Yilan , Zhang Yao
Published: July 2022

Background.
Sorafenib exhibits cardiotoxicity while the mechanisms are not elucidated. It is of great necessity to further explore the molecular mechanism of cardiotoxicity of sorafenib.
Methods.
All original dataset and results of user are downloadable in GEO (GSE119122) database with the high throughput sequencing results of sorafenib cardiotoxicity’s the differentially expressed genes (DEGs) by Sprague Dawley rats in RNA levels. The raw data was used to find the DEGs by Gene Ontology (GO) consortium, Protein-Protein Interaction (PPI) network, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses and Gene Set Enrichment analyses (GSEA). Representative DEGs of mannose receptor C-type 1 (Mrc1) and Fc gamma receptor I a (Fcgr1a) was verified by the real-time PCR (RT-qPCR). The levels of ROS were measured using Reactive Oxygen Species Assay Kit and dihydroethidium (DHE). The Cell Counting Kit-8 (CCK-8) experiment revealed H9C2 cell viability. We can observe intracellular microstructure by transmission electron microscopy (TEM).
Results.
Following the advent of R language, 31 DEGs between sorafenib damage and control group were analyzed. The KEGG analyses showed that the differential genes were expressed in phagosome signaling pathway. The genes of Mrc1 and Fcgr1a were markedly enriched in the phagosome signaling pathway. The outcome of RT-qPCR demonstrated that the sorafenib damage leads to profound decline of genes of Mrc1 and Fcgr1a level. Results demonstrate that sorafenib significantly reduces cell viability tested by CCK-8. Sorafenib could cause an increase of ROS levels and the TEM show that mitochondria-endoplasmic reticulum contacts and so forth.
Conclusions.
The results confirm our hypothesis that the molecular mechanism of sorafenib cardiotoxicity is associated with phagosome. It might be a potential diagnosis and therapeutic target for sorafenib exhibited cardiotoxicity.
Neonatal Mortality in Edward Francis Small Teaching Hospitals (EFSTH) Banjul, The Gambia, 2021: a need for neonatal mortality surveillance?
Authors: Jallow Bubacarr , Adewuyi Adebayo Peter , Umeokonkwo Chukwuma David , Jallow Amadou Woury , Jatta Joseph W , Jallow Ebrima K , Bittaye Mustapha
Published: July 2022

Background: Neonatal mortality surveillance has not been prioritized in The Gambia, despite the global target of the SDGs to reduce Neonatal Mortality Rate to <12/1000 livebirth by 2030. We conducted this study to describe the epidemiology of neonatal mortality in Edward Francis Small Teaching Hospital in the Gambia January to December 2021.Methods: We conducted a cross sectional study in (EFSTH) among neonates who died within the period under study. We extracted data from various sources in the hospital. We analyzed demographic variables, listed sources of data, and determined risk factors for death at 95% confidence interval. Results: Of the 306 neonatal deaths in 2021, 161 (52.6%) were female, the median age is 2.4 days at a range of 0.04-26 days. Majority 242 (79.1%) of the neonates that died in EFSTH were delivered via vagina spontaneously. There were more 174 (56.9) preterm and 95 (35.3%) very low birth weight babies. The highest cause of death was pneumonia among 82 (26.8%), while highest non-infectious cause of death was asphyxia accounting for 29 (9.5%) deaths. Male neonates and neonates born in Western regions (Western1 & 2) are more likely to die of infectious causes compared to those from other 5 regions [POR:1.36 (CI= 0.8513-2.1679)] and [POR 0.57 (CI= 0.2650-1.2120)] respectively. These possible risk factors are not statistically significant. Sources of data varies for each hospital: case folders, admission registers, hospital database and death certificates. Conclusion: We found that the neonatal mortality rate for the hospital is higher than the national one. More female neonates die and majority of the mortalities occur within the first day of life. More deaths occur in the Western Regions who are less likely to die of infectious causes as compared to other regions. The leading causes of deaths among neonates were found to be pneumonia, sepsis, low birth weights among others.
Correlation between thyroid function, sensitivity to thyroid hormones and metabolic dysfunction-associated fatty liver disease in euthyroid subjects with newly diagnosed type 2 diabetes
Authors: Zhang Xiaodan , Chen Yimei , Ye Huiyu , Luo Zirui , Li Jiahong , Chen Zhishan , Zhang Enting , Li Wangen
Published: July 2022

Purpose
To estimate the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and to evaluate the associations between thyroid parameters, MAFLD and liver fibrosis in euthyroid patients with newly diagnosed type 2 diabetes mellitus (T2DM).
Methods
Overall, 689 patients with newly diagnosed T2DM and 110 subjects without diabetes were included. All the participants were euthyroid, and were categorized as non-MAFLD and MAFLD. Demographic information, biochemical parameters, and serum thyroid hormones were collected. The thyroid hormone sensitivity indices were calculated. MAFLD was defined according to abdominal ultrasound and clinical manifestations. Noninvasive fibrosis indices were calculated to identify advanced liver fibrosis.
Results
The prevalence of MAFLD was significantly higher in patients with T2DM than in subjects without diabetes. Levels of free triiodothyronine (FT3) and FT3 to free thyroxine (FT4) ratio were significantly higher in subjects with MAFLD. In patients with T2DM, levels of thyroid stimulating hormone (TSH), Thyroid feedback quantile-based index (TFQIFT3) calculated using FT3 and TSH, thyrotroph T3 resistance index (TT3RI) and thyrotroph T4 resistance index (TT4RI) were significantly higher in subjects with MAFLD. The prevalence of MAFLD increased with the rise of FT3, FT3/FT4, TSH, and sensitivity to thyroid hormone indices (TFQIFT3, TT3RI, and TT4RI). Positive correlations were significant between FT3, TFQIFT3 and MAFLD. But after further adjusted for BMI and HOMA-IR, the correlations were not significant. The incidence of advanced fibrosis tended to increase as the rise of TSH and sensitivity to thyroid hormone indices (TFQIFT3, TT3RI, and TT4RI).
Conclusion
MAFLD was prevalent in euthyroid patients with newly diagnosed T2DM. Higher normal FT3, TSH and impaired sensitivity to thyroid hormones are associated with increased risk of MAFLD.
Adaptive coexistence of synchronization and anti-synchronization for a class of switched chaotic systems
Authors: Ren Ling
Published: July 2022

This paper addresses the problem of coexistence of synchronization and anti-synchronization (CSAS) for a class of switched chaotic systems by adaptive control method. The unified chaotic system as the subsystems of the switched system is investigated. Firstly, two theorems describe the necessary and sufficient condition for the CSAS of the chaotic systems and proofed rigorously. Secondly, according to the given two theorems, two algorithms are given to search the synchronization variables and anti-synchronization variables in the chaotic systems. Thirdly, the CSAS of the switched chaotic system can be achieved by the designed adaptive global controller with only one input channel under the arbitrary switching signal. Finally, the numerical simulation results verify the validity and effectiveness of the method we obtained.
Improved multi-trait prediction of wheat end-product quality traits by integrating NIR predictions
Authors: Azizinia Shiva , Mullan Daniel , Rattey Allan , Godoy Jayfred , Robinson Hannah , Moody David , Forrest Kerrie , Keeble-Gagnere Gabriel , Hayden Matthew J. , Tibbits Josquin FG , Daetwyler Hans D
Published: July 2022

Historically, end-product quality testing has been costly and required large flour samples and therefore, was generally implemented in late phases of variety development imposing huge cost on the breeding effort and effectiveness. High genetic correlations of end-product quality traits with higher-throughput and non-destructive testing technologies, such as near infra-red (NIR), could enable early-stage testing and effective selection on these highly valuable traits in a multi-trait genomic prediction model. We studied the impact on end-product quality trait accuracy of adding NIR phenotypes as a second trait in genomic best linear unbiased prediction (GBLUP) to increase training population size of six quality traits (crumb yellowness, water absorption, texture hardness, flour yield, grain protein, flour swelling volume). 1400-1900 bread wheat lines were measured during 2012-2019 in laboratory assays along with NIR records of approximately 27,000 lines. All lines were genotyped with the Infinium™ Wheat Barley 40K BeadChip and imputed using exome sequence data. End-product and NIR phenotypes were genetically correlated (0.5–0.83, except for Flour Swelling Volume 0.19). Prediction accuracies of end-product traits ranged between 0.28–0.64 and increased by 30% through inclusion of NIR predicted phenotypes compared to single trait analysis. There was a high correlation between the magnitude of multi-trait prediction accuracy and genetic correlations between end-product and NIR phenotypes (0.69–0.77). Our forward prediction validation revealed a gradual increase in prediction accuracy when adding more years to the multi-trait model. Overall, we achieved genomic prediction accuracies at a level that enables selection for end-product quality traits early in the breeding cycle.
Base editing derived models of human WDR34 and WDR60 disease alleles replicate retrograde IFT and hedgehog signaling defects and suggest disturbed Golgi protein transport
Authors: Antony Dinu , Güleç Elif Yýlmaz , Bakey Zeineb , Schüle Isabel , Kim Gwang-Jin , Skatulla Ilona , Cathomen Toni , Brunner Han , Arnold Sebastian , Schmidts Miriam
Published: July 2022

Cytoplasmic Dynein-2 / IFT-dynein is the only known retrograde motor for intraflagellar transport. Dysfunction of WDR34 and WDR60, the two intermediate chains of this complex, causes Short Rib Thoracic Dystrophy (SRTD), human skeletal chondrodysplasias with high lethality. Complete loss of function of WDR34 or WDR60 is lethal in vertebrates and individuals with SRTD carry at least one putative hypomorphic missense allele. Gene knockout is therefore not suitable to study the effect of these human missense disease alleles. Using CRISPR single base editors, we recreated three different patient missense alleles.Consistent with previous findings in the dynein-2 full loss of function models and patient fibroblasts, mutant cell lines showed hedgehog signaling defects as well as disturbed retrograde IFT. Transcriptomics analyses revealed differentially regulated expression of genes associated with various biological processes, including regulation of the actin cytoskeleton. Further, we observed differential regulation of genes associated with Golgi intracellular transport. In addition to providing cellular model systems enabling investigations of the effect of human SRTD disease alleles, our findings indicate non-ciliary functions for WDR34 and WDR60 in addition to the established roles as components of the retrograde IFT motor complex in cilia.
CT-maximal Diameters and mean CT value of Synchronous Multiple Lung Tumors Adenocarcinoma Are Smaller Than Solitary Lung Tumors In Pure Ground-glass Opacities
Authors: Wang Longfei , Zhao Lei , Zhao Weijun , Li Xinjian , Xu Qingtao , Liang Zhigang
Published: July 2022

Background: The features of multiple GGOs, especially for synchronous multiple pure GGOs (SMpGGOs), remains unknown. This retrospective study aimed to investigate the clinical and radiological features of SMpGGOs. Methods: Patients with solitary pure GGOs (SpGGOs) or SMpGGOs at Ningbo First Hospital from August 2018 to June 2020 were included. The clinical records and radiological image features between SpGGOs and SMpGGOs were compared. Data were analyzed using SPSS 21.0. Results: 138 patients (58 patients with 58 SpGGOs, 80 patients with 187 SMpGGOs) were evaluated. According to the multivariate analyses, maximal diameter (p＜0.001) and mean CT value (p=0.003) were independent risk factors. Receiver operating curves revealed that the optimal threshold of maximal diameters was 12.5 mm for SpGGOs (sensitivity 54.5%, specificity 100%, AUC 0.851) and 5.5 mm for SMpGGOs (sensitivity 86.4%, specificity 55.6%, AUC 0.777). The optimal threshold of mean CT value was -531.9 Hu for SpGGOs (sensitivity 43.2%, specificity 100%, AUC 0.724) and -615.0 Hu for SMpGGOs (sensitivity 61.4%, specificity 66.7%, AUC 0.651). Conclusion: The maximal diameters and mean CT value were significant independent predictors for adenocarcinoma of pGGOs. In SMpGGOs, the optimal threshold of maximal diameters and mean CT value of adenocarcinoma were smaller than those of SpGGOs.
Association between fetal sex and metabolic syndrome in women 40 and older: the REACTION study
Authors: Xie Qian , Li Ruoqing , Wan Qin , Tong Nanwei
Published: July 2022

Aims
The purpose of this study was to determine if fetal sex has an effect on risk of metabolic syndrome (MetS) in women in China.
Methods
A cohort of 3758 singleton pregnant Chinese women, aged 40 years or older were included. For each of these women, registry data on all pregnancies and miscarriages were obtained. This was a retrospective cohort study that aimed to determine whether fetal sex was associated with metabolic syndrome. We defined MetS as meeting five criteria, namely ineffective insulin metabolism, reduced glucose tolerance, high blood pressure, dyslipidemia and large waist size.
Results
Among 3758 singleton pregnant women 40 and older in Luzhou city, there were 1018 (27.1%) participants with incident MetS. Mothers carrying a male fetus(male group) had higher triglyceride(TG) and total cholesterol(TC) and showed greater diabetes background than the women carrying a female fetus (female group) (P < 0.05). MetS occurred more often with a male than female fetus but the difference was not statistically significant(P > 0.05). MetS frequency was statistically more in the male group than female group in postmenopausal women (P < 0.05). MetS occurred significantly less frequently in premenopausal compared to postmenopausal women in both the male and female group (P < 0.05). MetS occurred more often in the male group in postmenopausal women, showing statistical significance (P < 0.05).
Conclusions
Our study found that fetal sex was not associated with MetS in Chinese women 40 and older. But in postmenopausal women, MetS was seen statistically more often in the male group. We should pay more attention to postmenopausal women who have a male fetus and take early measures to prevent related chronic diseases.
Investigating potential gender-based differential item functioning for items in the Kansas City Cardiomyopathy Questionnaire (KCCQ) Physical Limitations domain
Authors: Coles Theresa M. , Lin Li , Weinfurt Kevin , Reeve Bryce B. , Spertus John A. , Mentz Robert J. , Piña Ileana L. , Bocell Fraser D. , Tarver Michelle E. , Saha Anindita , Caldwell Brittany
Published: July 2022

Background: Women with heart failure report worse health-related quality of life, on average, than men. Whether this is due to true differences in care or that women and men interpret and respond to survey questions differently is unknown. In this study, we investigate potential gender-based differential item functioning (DIF) on the Kansas City Cardiomyopathy Questionnaire (KCCQ) Physical Limitations (PL) domain.Methods: Using data from Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION), a multicenter, randomized controlled trial of exercise training in patients with chronic heart failure with reduced ejection fraction (1670 men, 661 women), we assessed gender DIF using item response theory (IRT)–based Wald test and ordinal logistic regression. Both methods evaluated how men and women responded to each KCCQ item after adjusting for their physical limitation status.Results: A 5-item version of the KCCQ PL domain was evaluated to satisfy statistical assumptions of DIF methodology. No KCCQ items exhibited statistically significant DIF using the IRT-based Wald method, and two items exhibited DIF using the ordinal logistic regression method (KCCQ1e: Climbing a flight of stairs without stopping; KCCQ1f: Hurrying or jogging) (p<0.01), but the magnitude of DIF was negligible. Conclusions: To accurately measure patient-reported outcomes, it is important to evaluate potential biases that may influence the ability to compare patient subgroups. The magnitude of DIF on the 5-item KCCQ PL domain was negligible.
Skilled aerobic exercise reduces endoplasmic reticulum stress and dopamine neuron apoptosis by activating Wnt/β-catenin pathway and improves motor function in PD model rats
Authors: Ruisi TIAN , Zhengquan ZHU , Hua GAO , LI Peishan , YANG Xinling , LI Yan-xia
Published: July 2022

Objective
To observe whether skilled aerobic exercise (SAE) could reduce endoplasmic reticulum stress(ERS) and apoptosis of dopamine neuron by activating Wnt/β-catenin pathway and improves motor function in Parkinson's disease(PD) model rats.
Methods
The PD models were established by injection into the right SNC(substantia nigra,compact part) and VTA(ventral tegmental area) on the rat stereolocator with 6-hydroxydopamine(6-OHDA). A cylindrical test was used to was used to test motor function. The expression of tyrosine hydroxylase(TH) in midbrain was detected by immunohistochemistry, the expression of genes and proteins related to the Wnt/β-catenin pathway was detected by Western blot. The level of Irisin in serum was identified through an enzyme-linked immunosorbent assay (ELISA).
Results
It was determined that 28 days of SAE improved motor function from Parkinson disease. In model group, the expression of TH in midbrain and FNDC5 in skeletal muscle was significantly down-regulated, the content of Irisin in serum decreased, the expression level of Bip/Grp78 and CHOP was up-regulated, the expression level of Wnt, β-catenin and P-GSK3β (Ser9) were down-regulated, while P-GSK3β (Tyr216) was up-regulated, the movement ability of forelimbs decreased (P < 0.05), and the rotation behavior induced by Apo significantly increased in model group (P < 0.05).
Conclusions
Mid-long term SAE could up-regulate the expression of FNDC5 in skeletal muscle, increase the content of Irisin in serum, reduce the level of ERS in midbrain, increase the activity of Wnt/β-catenin pathway, down-regulate the activity of Gsk3β, reduce the apoptosis of DA neurons in midbrain substantia nigra, and improve the motor function of PD model rats.
A Computer Tomography Radiomics-based model to Predict Survival of Patients with EGFR‑Mutated Non‑small‑cell Lung Cancer
Authors: Huang Chen , Cao Yubin , Zhu Lei , Xiong Qunli , Zhang Qin
Published: July 2022

Background
To evaluate the prognosis of EGFR-mutated non-small-cell lung cancer(NSCLC) patients and accurately target the patient subgroups with best potential outcome greatest, a simpler and more effective model based on readily available laboratory parameters is needed in clinical practice.
Methods
Totally, computed tomographic (CT) images from 162 EGFR-mutated NSCLC patients at the time of first diagnosis in West China Hospital of Sichuan University were retrospectively collected and analysed to describe the target area of the lesion. All patients were randomly divided into a training cohort and a validation cohort. Radiomic features from images were extracted. The least absolute shrinkage selection operator (LASSO) regression method was used to screen valuable radiomic features. The logistic regression method was used to establish a radiomic model, and the nomogram was used to evaluate the discrimination ability. Receiver characteristic curve (ROC) and decision curve analysis (DCA) were used to evaluate the performance of the model.
Results
We established a nomogram that combined 6 important clinical factors and imaging risk scores to predict the three-year and five-year survival rates of EGFR-mutated NSCLC patients. The AUC-ROC of three-year OS was 0.715, and the five-year OS was 0.705, which indicated a favourable discrimination capability of our nomogram and its great potential in targeting clinical services and predicting patient outcomes.
Conclusion
Based on chest CT imaging and clinicopathological features, including age, sex, Stage_T, Stage_N, Stage_M, clinical stage, and imaging risk score, we constructed and validated a nomogram for predicting an individualized prediction of survival for patients with EGFR‑mutated NSCLC.
The ceRNA network regulates epithelial–mesenchymal transition in colorectal cancer
Authors: Li Ruina , Gao Xiaoling
Published: July 2022

Epithelial–mesenchymal transition (EMT), a biological process transformed by a specific program, is involved in the progression and metastasis of colorectal cancer (CRC). Recently, emerging evidence showed that dysregulation of non-coding RNA (ncRNA) was related to EMT. The ncRNAs, including long non-coding RNA (lncRNA), regulate the transcription of downstream target genes (messenger RNA [mRNA]) through interaction with microRNAs (miRNAs); these are termed competitive endogenous RNA (ceRNA) networks. ceRNA dysregulation-induced EMT, which is closely related to the progression and prognosis of CRC, has attracted the attention of researchers. However, the understanding of ceRNA network regulation in CRC remains limited.We discussed the molecular functions of lncRNA, the ceRNA networks related to miRNAs and mRNAs in EMT, and EMT transcription factors zinc finger E-box binding homeobox 1/2 (ZEB1/2), SNAIL, SLUG, and TWIST1/2 regulated by the ceRNA network axis. In addition, the miRNAs and lncRNAs which directly target genes, thereby initiating different signaling pathways to promote EMT in CRC, were summarized. Clarification of the role of these molecules in the EMT is key for the diagnosis of CRC.
Physics with Continuum Energy Fields of Particles:Unified Equations of Motion from Planetary Motion to Quantum Mechanics
Authors: Misra Prasanta K. , Mansinha Lalu
Published: July 2022

The premise is that two energy fields influence all motion in classical physics. The first is the omnipresent Cosmic Background, the existence of which has been suspected for over a century, but with significant disagreement on the intensity. The second is the Mass Energy Field (ME) hypothesis on the existence of a localised energy field around every particle with mass and/or momentum. The spatial integral of the ME field for every massed particle is given by Einstein’s Mass Energy Equivalence Principle. The ME model leads to startling simplifications of several problems of significance of the past century that were considered almost intractable and required genius innovations: Einstein’s General Relativity (in the Solar System), 1916; Dirac Wave Function, 1928; and the Lamb Shift, 1947. The ME solutions, based on classical physics and conforming to Special Relativity, are simple, compact and do not require spacetime curvature, vacuum fluctuations, or renormalisation. For micro particles the ME model indicates a possible analytic expression for the Casimir Force, Lamb Shift, and the Strong Nuclear Force. The ME field around a massed particle, and the similar momentum energy field around a photon provide a plausible explanation for the century old vexing conundrum of wave-particle duality and points to a possible communication mechanism between quantum entangled particles. The Muon g-factor, computed with the ME expression, very different from existing QED theory, agrees with the measured value to 12 parts per billion. The ME theory shows exact agreement with General Relativity effects within the Solar System.
Angular Resolution improvement by conformal array with the 2-D Multiple Signal Classification (MUSIC) algorithm for RADAR
Authors: Jagtap Sheetal . G. , Kunte Ashwini
Published: July 2022

One of the most demanding requirement of RADAR system is estimation of Direction of arrival (DoA) estimation when two or more objects are very close to each other. It is quite difficult for any ranging and detection system to distinguish between them. Multiple antenna receiver technologies such as array antenna technology have advanced to the point, where they can achieve high angular resolution. Multiple antenna arrays are Planar array and Conformal array.Radiating elements are equally spread over surfaces in planar(URA) and conformal antennas apertures are of curved surface. Main problem with planar arrays is scan angles, are about +/-60 • from broadside.In conformal array, scan angle is about 360 • .This extended scan is very much useful for missiles and high speed air crafts radar, compare to planar array. So this paper checks how conformal array is better for high speed air craft’s radar system for achieving improved angular resolution. To achieve higher resolution in DoA estimation, subspace-based algorithms Multiple Signal Classification (MUSIC) is used with conformal array. This work focuses on comparing Conformal arrays and Uniform Rectangular arrays for DoA estimation. This paper examines the effect of using the MUSIC algorithm along with two different kinds of receivers to check for noise level and improved DoA resolution. Conformal array receivers shows two closely spaced objects are resolvable with 25 perecent improvement in azimuth angle and 68 perecent in elevation angle over the Uniform Rectangular Array(URA).As the number of array elements increased in conformal array,more accuracy in DOA estimation with reduced grating lobes achieved.The performance of these systems is assessed using computer simulation studies using Matlab. The findings shows conformal multi-array receiver outperforms URA receiver.
SARS-CoV-2 variants and the risk of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 in children in Germany
Authors: Anna-Lisa Sorg , Schönfeld Viktoria , Siedler Anette , Hufnagel Markus , Doenhardt Maren , Diffloth Natalie , Berner Reinhard , von Kries Rüdiger , Armann Jakob
Published: July 2022

Purpose: To investigate the risk of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in children depending on periods with different dominant variants of concern (VOC) of SARS-CoV-2.Methods: The risk of developing PIMS-TS in three phases of the pandemic with different VOC (Alpha, Delta, and Omicron) was calculated using data of rtPCR confirmed SARS-CoV-2 infections extracted from the German statutory notification system and reports of cases with PIMS-TS captured by a national, prospective registry. Overall and age group-specific rate ratios of PIMS-TS rates in the different observation periods, using the Alpha period as the baseline, were calculated.Results: The rate of PIMS-TS changed significantly over time. During April-August 2021, with dominant VOC Alpha_B.1.1.7, the PIMS-TS rate was 6.19 (95% confidence intervals (95% CI) 5.17, 7.20), decreased to 1.68 (95% CI 1.49, 1.87) in August 2021 to January 2022 with Delta_AY and to 0.89 (95% CI 0.79, 1.00) in January-April 2022 with Omicron_BA as dominant VOC. This corresponds to a decrease in PIMS-TS rate of 73% (rate ratio 0.271, 95% CI 0.222; 0.332) and 86% (rate ratio 0.048, 95% CI 0.037; 0.062), respectively, compared to the Alpha period. Rate ratios were almost identical for all age groups.Conclusion: The data strongly suggest a relation of the risk for PIMS-TS to the prevailing VOC with the highest risk related to Alpha_B.1.1.7 and the lowest with Omicron_BA. Uniformity of the decrease across age groups does not suggest a major role for vaccination on the risk of PIMS-TS in infected children.
Efficient CNN for High-Resolution Remote Sensing Imagery Understanding
Authors: Sinaga Kenno B.M. , Yudistira Novanto , Santoso Edy
Published: July 2022

Remote Sensing is one of the relatively complex problems in Machine Learning because of spatial patterns and intricate geometric structures of the data that make semantic understanding meaning essential in the remote sensing community. CNN is one of the Machine Learning methods often used in Remote Sensing problems. However, high-resolution aerial view classification often leverages large-scale data with a huge number of parameters of the CNN model. That large number of parameters makes it hard to be applied to remote imaging peripherals because it requires high capacity of storage and memory. We propose a training framework to solve that problem that produces a model with minimum parameters without sacrificing accuracy. In this study, the three CNN architectures are used to be compared: ResNet, Inception, and EfficientNet. Furthermore, the most efficient CNN backbone then leverages Freezing layers, adding Weighted Loss and Sparse Regularization during training and then Pruning after training. Using this method on the AID Dataset, the best results are achieved by EfficientNet-B0 with Freeze 2 Layer, INS Weighted Loss, Sparse regularization with lambda = 0.001, and Global Unstructured Conv2D Pruning with an accuracy of 95.86% on test data with total parameters of 2,463,501. This study proves that Weighted Loss and Sparse Regularization can help the model to improve accuracy while Pruning enhances efficiency by cutting the model parameters into a few.