bluuebunny/crossref_metadata_2025 huggingface dataset:
An affordable three-dimensional (3D) printed recording chamber for two-electrode
voltage clamp electrophysiology
Authors:   University of
            Richmond, Shogren Ian SK , Gonzales Jean P. , Boland Linda M.
Published: August 2023

Two electrode voltage-clamp (TEVC) electrophysiology in Xenopus oocytes is a
common approach to studying the physiology and pharmacology of membrane transport
proteins. Undergraduates may learn to use TEVC methodology in neuroscience or physiology
courses and/or in faculty-mentored research experiences. Challenges with the methodology
include the cost of commercially available recording chambers, especially when a lab
needs multiple copies, and the additional time and expertise needed to use agar bridges
and to stabilize solution flow and minimize noise from solution aspiration. Offering a
low-cost and accessible recording chamber that overcomes these challenges would lower
the barriers to success for undergraduates while also supporting publication-quality
recordings. To address these issues, we developed a recording chamber using
stereolithography, a 3D printing process. The physiology (PhISio) recording chamber
features two options for solution aspiration that allow for individual preferences,
optimizes placement of pre-made agar bridges to achieve laminar flow and reduce the time
delays in initiating daily experiments, and minimizes the challenges of changing
solution height and aspiration noise during perfusion. We compared the functionality of
the PhISio chamber with a commercially available Warner Instruments RC-1Z chamber in
electrophysiological recordings of inwardly rectifying potassium channels expressed in
Xenopus oocytes. The PhISio chamber produced equivalent results to the RC-1Z chamber
with respect to time-dependent solution changes and has several operational advantages
for both new and experienced electrophysiologists, providing an affordable and
convenient alternative to commercially available TEVC recording chambers.
An Undergraduate Laboratory Series Using C. elegans That Prepares Students for
Independent Inquiry
Authors:   Wellesley College, Quinan Virginia , Hsu Kelly , Mann Molly , Barclay Kia , Bauer Deborah
Published: August 2023

Undergraduate neuroscience laboratories provide valuable opportunities for
students to learn about neurobiological systems through active learning. Caenorhabditis
elegans (C. elegans) is a valuable model for teaching students how to use a reductionist
approach to neuroscientific inquiry. This series of lab modules trains students to
utilize foundational laboratory techniques such as worm handling and maintenance,
fluorescence imaging, behavioral assays, and Western blot. Upon completing this series
of laboratory exercises, students are well prepared to engage in independent research
projects using these research techniques. As supported by student survey results, this
series of C. elegans laboratory exercises leads to the development of essential research
skills, which students may be able to apply to a wide range of future scientific
endeavors.
Aula Magna do Departamento de Filosofia do ano de 2010
Authors: Japiassu Hilton
Published: August 2023

Prof. Dr. Hilton Japiassu
A Questão das Terras Indígenas e os Governos Brasileiros do Século XXI
Authors: Reis Max
Published: August 2023

Com os recentes retrocessos no que se refere às conquistas constitucionais indígenas, o cenário das lutas pela retomada das terras ganha uma considerável repercussão política e muitos são os discursos sendo elaborados a fim de disputar palanques. Enquanto isso, o reconhecimento dos direitos indígenas pela Constituição de 1988, ainda que tenha sido uma grande vitória, mostra-se insuficiente, visto que não garantiu efetivamente o repasse dos territórios. Dessa forma, um processo que deveria ter sido finalizado no prazo de cinco anos, ainda enfrenta inúmeras represálias para que não seja concluído, de modo que permite a atuação de garimpeiros, latifundiários e grandes fazendeiros, favorecendo a destruição da natureza. Diante disso, o presente artigo busca expor as raízes históricas da perseguição contra os povos originários e procura compreender como os últimos quatro governantes (Lula, Dilma, Temer e Bolsonaro) lidaram com a questão das demarcações e homologações das terras indígenas durante seus mandatos.
A REDE DOS ANARQUISTAS ITALIANOS EM SÃO PAULO NO INÍCIO DO SÉCULO XX
Authors: Romani Carlo Maurizio , E Benevides Bruno Correia de Sá
Published: August 2023

O fluxo migratório de anarquistas italianos, tendo como destino o cone Sul-Americano, fez parte das redes transnacionais construídas pelos militantes, especialmente entre o final do dezenove e início do século XX. O encontro de muitos anarquistas italianos em São Paulo permitiu a criação de vários grupos de afinidades para o aperfeiçoamento da propaganda. Através das análises biográficas dos principais anarquistas que escreveram no periódico La Battaglia (Oreste Ristori, Alessandro Cerchiai, Angelo Bandoni, Tobia Boni e Gigi Damiani), pretendemos demonstrar que tais relações de afinidades foram mediadas a partir das identidades sociais desses ativistas. Nos últimos anos, os anarquistas italianos em São Paulo têm sido classificados como sendo individualistas por uma nova historiografia que não é capaz de investigar as peculiaridades deste grupo. Portanto, esta proposta compartilha a ideia de que o anarquismo transatlântico, em razão de sua complexidade, apenas pode ser compreendido por análises específicas.
Epistemologias dos Odus e Decolonialidade Afro-Brasileira
Authors: Miranda Eduardo Oliveira
Published: August 2023

RESUMO: O artigo aponta caminhos para romper com as estruturas ocidentalizadas e suas consequências para os corpos-territórios subalternizados. Destarte, como estratégia política de tensionametos, lanço, mesmo que de forma embrionária, as Epistemologias dos Odus, com o amparo filosófico de Exu, cuja finalidade busca fissurar as colonialidades e oportunizar a expansão do que batizei de Decolonialidade Afro-Brasileira.
Capoeira, uma experiência anarquista
Authors: MARTIELO RENATA GIOVANA DE ALMEIDA
Published: August 2023

Este artigo é um convite para pensarmos sobre as possíveis e necessárias interfaces da capoeira com a construção de uma sociedade igualitária, livre e justa, através de um projeto que enfrente as colonialidades do saber e do ser. Valorizaremos ações que privilegiem e favoreçam os saberes que se constroem nas experiências vividas, a partir da prática da capoeira e de corpos de seres africanos na diáspora brasileira, LGBTs, dos corpos dos excluídos. Consideraremos esses como pensadores/as que estão fora das instituições acadêmicas produzindo saberes a partir de seus corpos em movimento. Assim, as lutas por existência das populações em situação de moradores de rua e da comunidade LGBTs serão tratadas como processos de produção de conhecimento contra hegemônicos, de autodeterminação e de produção de reexistência. A expressão desses corpos vivos e invisibilizados no dia a dia da cidade será nossa base de interpretação.
A JUÍZA, O DEPUTADO E O PASTOR - O DISCURSO DE ÓDIO AOS DIREITOS HUMANOS E À MARIELLE FRANCO
Authors: Nascimento Amadeu Cardoso
Published: August 2023

Este trabalho se ampara em dados de pesquisa antropológicos e interdisciplinares e tem por objetivo analisar as intolerâncias raciais e de gênero sofrida por Marielle Franco após seu assassinato em 2018. A pesquisa monitorou portais de comunicação jornalística, selecionando reportagens publicadas entre 2018 e 2021, usadas como fontes para a realização desta pesquisa. A partir disso, busquei centralizar nossa análise com base em conceitos de categorias apresentadas por Richardson (1999). Centralizei o debate nas categorias direitos humanos, de minorias raciais e sexuais que Marielle defendia. O crime em questão, associado a um cenário de crise política no Brasil com a eleição de Jair Messias Bolsonaro à presidência da república, polariza um campo de disputa de poder político. Os discursos de ódio direcionados à Marielle Franco atingem suas pautas e lutas em defesa dos direitos humanos. O ódio promovido e espalhado sobre a figura da militante indica racismo, homofobia e intolerância.
Monoclonal Antibody Therapies for Neuromyelitis Optica Spectrum Disorder
Authors: Kim Woojun
Published: August 2023

Neuromyelitis optica spectrum disorder (NMOSD) is caused by antibodies that target the aquaporin-4 (AQP4) water channel expressed on astrocytes. Specific antibody binding to AQP4 produces complement-dependent cytotoxicity, resulting in inflammation and demyelination. New biologic treatments demonstrate high efficacy and good safety for patients with AQP4-immunoglobulin G-positive NMOSD. They were eculizumab, an anti-complement C5 antibody, satralizumab, an anti-interleukin-6 receptor antibody, and inebilizumab and rituximab, which targets CD19 and CD20, respectively, causing depletion of B-cells. In this review, the pathophysiology of NMOSD, the methodology and results of the recent studies examining monoclonal antibody therapies, and the optimal therapeutic strategy for NMOSD were covered.
New Therapeutic Agents in Myasthenia Gravis
Authors: Kim Jinhee , Shin Ha Young
Published: August 2023

Myasthenia gravis (MG) is an autoantibody-mediated neuromuscular junction disorder characterized by fatigable muscle weakness. Mainstay therapies for MG include anticholinesterase inhibitor, thymectomy, corticosteroids, and non-specific immunotherapy, such as azathioprine, tacrolimus, mycophenolate mofetil, intravenous immunoglobulin, and plasma exchange. These therapeutic methods have significantly improved MG treatment in recent decades. However, there are still some patients with MG refractory to conventional treatments. In addition, long-term use of corticosteroids and non-specific immunosuppressants can lead to serious complications, including metabolic derangement, infections, malignancies, and systemic organ dysfunction. Recently, new therapeutic agents have been developed based on advancements in our understanding of the immunopathogenesis of MG. These agents are more specific and have a more rapid effect compared with conventional treatments. This article reviews novel therapeutic agents and their scientific basis.
Rituximab Treatment for Neuroimmunologic Disorders
Authors: Yoo Ilhan
Published: August 2023

Rituximab is a monoclonal chimeric antibody that targets CD20, which is expressed on the surface of B cells ranging from pre-B cells to mature B cells; rituximab treatment leads to depletion of B cells. It is widely used to treat various autoimmune neurological diseases including neuromyelitis optica spectrum disorder, multiple sclerosis, myasthenia gravis, chronic inflammatory demyelinating polyradiculoneuropathy, and autoimmune encephalitis. When administering rituximab for treatment, it is essential to consider potential adverse reactions, such as hypersensitivity, infection, and hypogammaglobulinemia, and to monitor B cell levels regularly to maintain the efficacy of treatment and prevent relapse. This review aims to explore the treatment of neuroimmunologic disorders with rituximab.
Multiple Sclerosis in Korea: A Hospital-Based, Multicenter, Epidemiological Study
Authors: Kim Su-Hyun , Lee Eun-Jae , Min Ju-Hong , Kim Sung-Min , Shin Ha Young , Kwon Young Nam , Kim Woojun , Oh Jeeyoung , Kim Jun Soon , Baek Seol-Hee , Joo In Soo , Hong Yoon-Ho , Park Min Su , Sohn Eunhee , Nam Tai-Seung , Oh Sun-Young , Huh So-Young , Lee Tae-Kyeong , Yang Jiwon , Kim Sunyoung , Seok Hung Youl , Kim Nam-Hee , Shin Jin-Hong , Bong Jeong Bin , Kwon Soonwook , Oh Seong-il , Cho Eunbin , Shin Hyun-June , Lee Hyung-Soo , Park Kee Hong , Kim Woo Kyung , Bae Jong Seok , Kim Ho Jin
Published: August 2023

Background: In the present era of rapidly evolving treatment options, there is a need for better understanding of the epidemiology and current management of patients with multiple sclerosis (MS). A survey was conducted to determine the epidemiologic characteristics and the current treatment status of patients with MS in Korea.Methods: In April 2022, we collected data on patients with MS, including number participating in follow up, sex ratio, current disease modifying treatment (DMT), and disability status (Expanded Disability Status Score, EDSS) from 30 major MS centers in Korea.Results: A total of 1,290 patients with MS was identified, with a female to male ratio of 2.4:1. Geographically, 1,047 patients (81%) were being monitored at hospitals in the capital regions (Seoul, Incheon, and Gyeonggi-do), while 243 (19%) were receiving care at hospitals outside the capital regions. There were 1,199 patients on DMTs, with 876 (73%) taking drugs with moderate efficacy and 264 (22%) taking drugs with high efficacy. Patients with current EDSS score greater than 3.0 and 5.5 numbered 242 (20%) and 105 (9%), respectively.Conclusion: The hospital-based prevalence survey revealed the number and geographical distribution of patients with MS in Korea.
Vasculitic Neuropathy Associated with Pembrolizumab
Authors: Seo Dongjin , Shin Ha Young , Kim Jin Ho , Kim Se Hoon , Kim Seung Woo
Published: August 2023

Immune-related neuromuscular complications due to immune checkpoint inhibitors (ICIs) are widely reported. However, cases involving vasculitic neuropathy (VN) are rare. We report a case of pembrolizumab-associated VN, confirmed by nerve biopsy, presenting as mononeuritis multiplex with erythematous skin lesions. Based on negative serological tests for other causes of vasculitis and temporal relationship with ICI treatment, vasculitis was suspected to be associated with pembrolizumab. VN should be considered in patients with progressive neurological symptoms and skin lesions after receiving ICI therapy.
Reversible Splenial Lesion Syndrome Associated with Encephalitis/Encephalopathy Improved with Short-Term Steroid Treatment
Authors: Lim Sung Chul , Oh Juhee , Park Jeonghyun , Kim Sanghyun , Lee Jusuck
Published: August 2023

Reversible splenial lesion syndrome (RESLES) is a complex clinicoradiological entity that has been reported to occur secondary to several disorders, including acute encephalitis/encephalopathy. On magnetic resonance imaging, it presents as reversible hyperintense signal lesions on diffusion-weighted images and hypointense on apparent diffusion coefficient images. Most case of RESLES associated with encephalitis/encephalopathy have a good prognosis, but some require intensive care or have poor prognosis. We report a case of RESLES associated with encephalitis/encephalopathy in which neurological deterioration improved after steroid treatment.
Bruton’s Tyrosine Kinase Inhibitors for Multiple Sclerosis
Authors: Shin Je-Young , Ahn Suk-Won
Published: August 2023

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with a chronic and often progressive disease course. The current disease-modifying treatments (DMTs) limit disease progression primarily by controlling immune cell activity in the peripheral blood or inhibiting their migration from the periphery into the CNS. However, approved therapies are less effective at slowing disability accumulation in patients with MS, and new therapies are needed to target CNS immunopathology, which is a key driver of disability progression in MS. Bruton’s tyrosine kinase (BTK) is an intracellular signalling molecule involved in the regulation of maturation, survival, migration and activation of B cells and microglia, therefore BTK inhibitors target both adaptive and innate mechanisms that contribute to the immunopathology of MS on both sides of the blood-brain barrier. This article reviews the preclinical researches and therapeutic roles of Bruton's tyrosine kinase inhibitors as promising DMTs to target cells of the adaptive and innate immune system outside and within the CNS in the MS.
Biosensors – Fundamental And Applications
Authors:   Founder and Director   BYOS Scientific Lab, Mowa Raipur, Chhattisgarh, India, Kumar Lautre Hitendra
Published: August 2023

This book focuses on the state-of-the-art of biosensor research and development for specialists and non-specialists. It introduces the fundamentals of the subject with relevant characteristics of transducer elements, as well as biochemical recognition molecules. This book is ideal for researchers of nanotechnology, materials science and biophysics.
Effect of Academic, Social, and Personal-emotional Adjustment on Understanding Accounting Courses through Grade Point Average as an Intervening Variable in Development Economics Students at Universitas Negeri Malang
Authors: Sahatta Mahendra Dwianggana , Nasikh Nasikh , Haryono Agung
Published: August 2023

The transition of students from high school to college experiences several differences including learning methods, learning materials, and new environments. Adaptation or self-adjustment is needed in new students, from existing adaptations, it is developed to understand accounting courses because accounting is important for the world of work for both educators and non-educators. Initial observations made by students have good GPA scores, have good relationships with each other, but are still not maximized in the value of accounting course assignments, and still experience psychological problems when doing assignments. This study uses a quantitative approach with an explanatory type of research. The population used in this study is 2nd-semester students majoring in development economics who have taken introductory accounting and financial accounting courses. The sampling technique used a random sampling system of 92 students. Data collection using questionnaires and test tests. The data analysis used is descriptive statistics, inner model, outer model, path analysis, and Structural Equation Modeling (SEM) analysis with Smart-PLS 4. The results showed that the direct effect, namely: variable X1 has no effect on Y, variable X2 has an effect on Y, variable X3 has an effect on Y, variable X1 has no effect on Z, variable X2 has an effect on Z, variable X3 has an effect on Z and variable Y has an effect on Z while in indirect effects, namely: variable X1 has no effect on Y through Z, variable X2 affects Y through Z and variable X3 affects Y through Z
Hydrogeology and irrigation potential of the West Crane aquifer, Richland County, Montana
Authors:   Montana Bureau of Mines and Geology, Reiten J. , Chandler K.
Published: August 2023

The West Crane aquifer is contained in a buried valley incised into the Fort Union bedrock. This publication describes the location, extent, groundwater flow, recharge, discharge, hydraulic properties, and water quality of the West Crane aquifer. Demand for developing this aquifer for irrigation is growing and a groundwater model is being developed to evaluate aquifer sustainability.
Groundwater quantity and quality near Hamilton
Authors:   Montana Bureau of Mines and Geology, Myse T. , Hanson A.E.H.
Published: August 2023

An investigation of how land-use changes may affect groundwater and surface-water levels in the Hamilton area, as well as a comparison of historical and current nitrate values.
Globalizmi i çështjeve detare e oqeanike nën optikën ligjore të administrimit detar
Authors:   University Ismail Qemali Vlore, Xhelili Ermal , Elezi Myzafer ,   Reald University College
Published: August 2023

Objektivi themelor i administrimit detar bazohet në implementimin e strategjive politike, ekonomike dhe sociale kombëtare, si dhe të standarteve dhe kërkesave të konventave ndërkombëtare të detit në mënyrë që të ketë një administrim të mirë të çështjeve detare kombëtare. Administrata Detare është institucioni i specializuar që administron hapësirën detare, dmth, që duhet të merret direkt me politikbërjen, funksionet rregullatore dhe krijimin e legjislacionit detar të shtetit shqiptar, duke kontribuar kështu në mbrojtjen në mënyrë të efektshme të interesave kombëtare në det. Rëndësia e madhe që ka krijimi dhe ekzistenca e Administratës Detare qëndron në promovimin që ky institucion duhet t’i bëj progresit dhe prosperitetit të industrisë detare, flotës tregetare, detarëve të punësuar në këto anije, si dhe përdorimit eficent, zhvillimit dhe optimizimit të resurseve të gjalla të detit, shfrytëzimit të resurseve energjitike dhe minerale të tabanit të detit, dhe mbrojtjes së mjedisit. Qëllimi kryesor i këtij materiali është të analizojë rolin e Adminstratës Detare në lidhje me menaxhimin e çështjeve bazë që rregullojnë marrëdhëniet e industrisë detare, duke analizuar fillimisht konceptin e këtij institucioni detar të rëndësishëm, dhe më pas strategjinë e zhvillimit të çështjeve të detit, duke përfunduar me një diskutim rreth kornizës ligjore që i mundëson Administratës Detare të implementojë objektivat, strategjitë dhe politikat e saj në sferën detare, dhe efikasitetin e saj drejt administrimit të cështjeve detare kombëtare.
Kujdesi infermieror në trajtimin e glaukomës
Authors:   Reald University College, Sinanaj Arnold
Published: August 2023

Glaucoma is a complex disease which causes blindness if not treated in time. It also affects the quality of life of these individuals. Vision loss due to glaucoma cannot be recovered, so it is important to perform regular examinations that include measurements of your eye pressure, so that one can establish a diagnosis in its early stages and treat it in the right way. right. Optic nerve damage and visual loss resulting from glaucoma can be prevented through early diagnosis, effective treatment, and treatment compliance. In the treatment of glaucoma, a multidisciplinary cooperation is required where nurses have a key role. They provide education, advice and reassurance to these patients. Also, fundamental remains the increase of patients’ knowledge about the nature of the disease, risk factors, symptoms and types of treatment.
Ndryshimet hematologjike gjatë infeksioneve nga Helicobacter Pylori
Authors:   Reald University College, Lekaj Seljana
Published: August 2023

In the patients taken in the study, the cause of hematological disorders is gastritis from the presence of H. Pylori infection. Therefore, the object of our study is to establish the serological examination of H. Pylori as a routine examination in the medical service, and to show that proper care against H. Pylori and the gastritis caused by it, quickly improves the disorders in the blood parameters. In addition to interest in the role of H. pylori in hematologic disorders, idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, there are many scientific studies and a growing interest in other conditions, such as cardiovascular, neurological, dermatological, obstetric, metabolic and immune diseases. During the period January 2019 – June 2020, about 150 patients presented to the clinic due to gastro- hematological disorders were examined and only 107 patients (50 females and 57 males) were selected who, in addition to the examination of hematological parameters (Cell Cunter Micros 60 and ECO autoanalyzer) also performs the test for IgG anti-H. Pylori (ELISA technique (Abbott Comander)).The results were statistically processed and it was concluded that the prevalence of anemia in the group that tested positive for H. Pylori infection is higher than the prevalence of anemia in the group that tested negative for H. Pylori, so the exposure to H. Pylori infection is positive associated with the presence of anemia. Proper medical therapy, proper examination and the provision of complete care, lead to the avoidance of the cause of discomfort and improves the patient’s condition.
La educación en la antigüedad y la edad media
Authors: Mosquera Salazar Eliana
Published: August 2023

El presente documento es un abordaje muy general de algunas de las características situacionales de la educación en la edad antigua y la edad media en donde a partir de algunas investigaciones se analizan tanto el rol del docente, como el de los estudiantes y la sociedad. A manera ilustrativa, se tiene que la época clásica o antigua forjó lazos para procesos educativos, elitistas, selectivos y en ocasiones en sitios específicos pero que tenían como punto esencial, el humanismo. Por otro lado, con la llegada de las conquistas y el poder de la iglesia, la edad media fue caracterizada por procesos educativos también selectivos y más relacionados con la parte espiritual, teocéntrica y de valores.
EL DISEÑO GRÁFICO Y LA LETRA. PRODUCCIÓN EN LA ANTIGUEDAD Y LA EDAD MEDIA
Authors: Bermúdez Castillo Jairo Alfredo , Delgado Osorio Claudia Patricia
Published: August 2023

Este paper presenta un avance de la investigación sobre la historia del diseño gráfico que se adelanta para la Poetophia & Science Corp. Trata sobre la escritura y su representación visual como objeto de estudio, lo cual, a la alarga, son fonemas sintetizados en patrones gráficos basados en la abstracción de líneas, ángulos, puntos y curvas, comprensibles tras un aprendizaje cultural y evolutivo, anexo a distintos momentos históricos en la antigüedad y en la edad media. Evolución de la letra. La escritura es susceptible de analizarse como abstracción visual para la comprensión de signos o letras, que, finalmente se usan en el mundo contemporáneo y su formalización tuvo distintos momentos cumbre en la antigüedad y la edad media. Los exponemos en nuestro texto. La metodología para la construcción de la propuesta es la búsqueda sistemática en cuanto a consulta bibliográfica, la cual se complementa con algunos registros de imágenes en trabajo de campo in situ.
LA RELIGIÓN CRISTIANA NICENA, INSTITUCIÓN QUE TRASCENDIÓ LA EDAD ANTIGUA.
Authors: Rodriguez Berdugo Javier Eduardo
Published: August 2023

Este artículo busca analizar la transición del cristianismo de la antigüedad al medioevo. Su persecución, tolerancia y final adopción como religión del Imperio romano. El cesarpapismo y el aumento de adeptos y prelados pertenecientes a la aristocracia. Las adopciones de cánones conciliares que fortalecieron la doctrina y la estructura jerárquica de la Iglesia. El cristianismo no solo transitó a época medieval, sino que también se consolidó y perdura hasta hoy.
GNOSEOLOGÍA DEL CONSUMIDOR EN COLOMBIA PARA LAS MARCAS DE MUEBLES Y ACCESORIOS DOMÉSTICOS.
Authors: Vásquez Jose Miguel
Published: August 2023

Este artículo es un derivado de una investigación cuyo objetivo es comprender el perfil del consumidor digital de las marcas de muebles y accesorios domésticos en Colombia. Para ello se aborda una revisión bibliográfica sistemática del tema, con el fin de definir el concepto de Live Shopping, el camino de este formato para llegar a Colombia. Esta definición es posible extrapolarla al entorno nacional gracias al análisis de los factores que afectan las decisiones de compra de los usuarios en Asia, continente donde el objeto de estudio cuenta con variados casos; esto permite un primer acercamiento al entendimiento de este consumidor en Colombia con mayor énfasis hacia la categoría de Muebles y Accesorios, actividad del e-commerce con amplio potencial.
TATYANA ALLIK - THE WAY TO SUCCESS
Authors: Hrustalev Nikolay
Published: August 2023

This article will focus on Tatyana Allik, a psychologist, music therapist, master of correctional pedagogy with 30 years of experience, and finally, an extraordinary person who founded one of the most successful rehabilitation centers in Estonia "Doctor Music from Estonia" OÜ, which today is known far beyond the EU .
THE MUSIC AND PSYCHOLOGICAL IMAGES IN THE BALLET PHANTASY “DREAM” BY DOCTOR OF MEDICINE EDUARD HAMBARTSOUMIAN
Authors: Asatryan Anna
Published: August 2023

The paper examines the one-act ballet phantasy “Yeraz [Dream]” by the renowned gynecologist, specialist in the field of reproductive medicine, director and founder of the “Center of Reproductive Medicine” in Yerevan, President of the Armenian Society of Reproductive Medicine, Doctor of Medicine Eduard Hambartsoumian. Since 2015, the ballet has established itself in the repertoire of the A. Spendiaryan Yerevan National Academic Theater of Opera and Ballet.

The libretto is written by the prima ballerina of the Yerevan Opera and Ballet Theater, Merited Actress of Armenia Jacqueline Sarkhoshyan – the first and unexcelled performer of the main role.

The composer used a musical quotation from the Armenian folk song “Yeraz [Night Dream]” to the words of Smbat Shahaziz (Shahazizyan); the tune undergoes various rhythmic and timbre modifications throughout the performance.

For the first time in the world, the art of sand animation is employed in the scenic design and artistic interior of a ballet performance (Anna Amas).
MUSIC, UNIVERSALS OF GENOMIC DNAs, GENETIC INTELLIGENCE, AND THE CONCEPT OF A STOCHASTIC SYSTEM OF PROTOREGULATION
Authors: Petuhov Sergey
Published: August 2023

This work is devoted to the structural links between the musical harmony of the Pythagorean fifth scales and the system of hydrogen bonds in genetic molecules DNAs. Hidden regularities in the stochastic organization of hydrogen bond sequences in the genomic DNAs of higher and lower organisms have been discovered. The regularities described are candidates for the role of universal regularities of biological evolution. An idea is advanced on the fundamental role of stochastic regularities in the genetically inherited organization of biological bodies. In the presented study, the author's method of binary stochastics hierarchy for genetic and physiological studies was used.
Cybersecurity for Research:
Authors: LaSalle Connie , Howell Gema , Martinez Leilani
Published: August 2023

Unmanaged cybersecurity risks can wreak havoc on a community. This is no less true for the U.S. scientific research ecosystem, particularly members of the higher education research community, which can be characterized by its fundamentally open, collaborative culture and web of highly decentralized administrative and research environments. Securing the digital resources that contribute to a thriving higher education research enterprise requires consideration of the threats and vulnerabilities relevant to the community as well as unique mission contexts, cultures, and motivations. This resource is intended to enable institutions of higher education to identify, assess, manage, and reduce cybersecurity risks related to conducting research, as described in Section 10229 of the CHIPS and Science Act.
ANALISIS PENERAPAN PENGEMBANGAN KARIER PEGAWAI PADA PUSAT PELATIHAN DAN PENGEMBANGAN DAN KAJIAN DESENTRALISASI DAN OTONOMI DAERAH LEMBAGA ADMINISTRASI NEGARA
Authors: Cahyaningsih Elin , Anggraeni Fitria Resti
Published: August 2023

Pengembangan karier pegawai merupakan suatu hal yang penting bagi pegawai dalam suatu organisasi. Seorang pegawai mengharapkan adanya perubahan, perkembangan, kemajuan, dan kesempatan yang diberikan oleh organisasi kepadanya untuk maju ke tingkat yang lebih tinggi dan lebih baik. Pegawai tentu mengharapkan bahwa kariernya dapat berjalan dengan baik dan berkembang sampai dengan jenjang tertinggi yang dapat diraih. Oleh karena itu, suatu organisasi perlu menerapkan pengembangan karier bagi pegawainya untuk memotivasi mereka agar dapat bekerja lebih optimal. Tujuan dari penelitian ini adalah untuk mengetahui penerapan pengembangan karier pegawai Puslatbang KDOD. Penelitian ini dilakukan dengan pendekatan kualitatif berdasarkan hasil wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa pengembangan karier pegawai Puslatbang KDOD diterapakan melalui langkah-langkah pengembangan kompetensi, mutasi, promosi dan penilaian potensi. Kendala yang dihadapi terkait perencanaan karier pegawai, proses pengumpulan angka kredit, perbedaan persepsi karier dan kurangnya motivasi individu. Strategi optimalisasi pencapaian pengembangan karir dapat dilakukan dengan dialog anatara pegawai dan organisasi, peningkatan pengetahuan, penyelesaian tusi, penyusunan rencana karier.
Depressão na mídia: uma análise discursiva
Authors: Lunkes Fernanda Luzia , Souza Illana Araújo
Published: August 2023

Depressão na mídia: uma análise discursiva, apresenta os estudos linguísticos sobre o tema da depressão em notícias veiculadas em conhecidos portais de notícias da internet. Fazendo uso do aporte teórico da Análise do Discurso, a prof. Fernanda Lunkes e a estudante Illana Araújo Souza buscam situar os processos de produção de sentidos sobre a depressão no discurso jornalístico.
O uso da telemedicina na atenção básica e suas implicações em tempos de covid-19
Authors: Carmo Lorena Aguiar do , Guimarães Jane Mary de Medeiros , Cardoso Antonio José Costa
Published: August 2023

O trabalho denominado O uso da telemedicina na atenção básica e suas implicações em tempos de covid-19, do prof. Antônio José Costa Cardoso e da estudante Lorena Aguiar do Carmo, em coautoria com a prof. Jane Mary de Medeiros Guimarães, trata da identificação de experiências de aplicação da telemedicina na Atenção Primária à Saúde (APS). O trabalho apresenta um estudo de iniciativas e contribuições para o enfrentamento da pandemia da doença causada pelo novo coronavírus (covid-19) no campo das atividades da telemedicina, o qual ganhou destaque especialmente no contexto da pandemia.
Atividade Leishmanicida de Compostos Bioativos de Piper Macedoi
Authors: Santos Victor Neves dos , Oliveira Gisele Lopes de , Ferreira Sebastião Rodrigo
Published: August 2023

O trabalho, Atividade Leishmanicida de Compostos Bioativos de Piper Macedoi, de autoria do prof. Sebastião Rodrigo Ferreira e do discente Victor Neves dos Santos, em coautoria com a prof. Gisele Lopes de Oliveira, busca identificar os compostos de origem natural com possível atividade leishmanicida como alternativa aos medicamentos usados atualmente para o tratamento da leishmaniose, os quais contêm alta toxicidade e geram muitos efeitos colaterais. No estudo foi utilizado o óleo essencial 10 da espécie Piper macedoi da família Piperaceae, que, ainda com resultados preliminares, apresenta potencial biotecnológico de um futuro candidato a fármaco para o tratamento dessa doença.
Bien-être psychosocial de femmes âgées ayant vécu un épisode de maltraitance1
Authors: Lepage Andrée-Anne , Lapierre Sylvie , Beaulieu Marie , Aubin Ginette
Published: August 2023

L’objectif de la présente étude était de comparer le bien-être psychosocial actuel de 16 femmes âgées de 65 ans ou plus, vivant dans la communauté, à celui de 19 femmes rapportant n’avoir jamais vécu d’épisode de maltraitance dans leur vie. Bien que la littérature scientifique suggère que la détresse psychologique soit l’une des principales conséquences de la maltraitance, les résultats font surtout état de différences en lien avec les dimensions sociales. Les femmes ayant été maltraitées considèrent avoir peu de soutien de leur famille, un faible lien d’attachement avec d’autres personnes et n’ont personne à qui s’adresser pour obtenir conseils.
Réflexion sur le terme « incasable » : l’exemple d’un jeune, Laurent
Authors: Devaux Marina , Chaudoye Guillemine , Riazuelo Hélène
Published: August 2023

Cet article a pour objectif de bannir l’étiquette « incasable » qui est facilement attribuée à certains jeunes placés en protection de l‘enfance. En effet, c’est un public avec lequel il est difficile de travailler de par la complexité de cette clinique. Les termes pour désigner ces jeunes sont nombreux, que ce soit en France ou au Canada : « jeunes délinquants », « jeunes multiproblématiques », « adolescents difficiles » … À partir d’un cas clinique, nous interrogeons le fonctionnement psychique d’un jeune dit « incasable » nommé Laurent. Nous soulignons l’idée de la nécessité d’aller à la rencontre de ces jeunes. Un investissement du lien professionnel-jeune étayé sur un tiers institutionnel, leur permet de décoller cette étiquette « incasable » en devenant sujet.
Utilité et désirabilité professionnelles de la civilité
Authors: Grimault Valérie , Rezrazi Amine , Valeau Patrick , Gangloff Bernard
Published: August 2023

La littérature enseigne que certaines normes sociales sont enracinées dans l’utilité, d’autres dans la désirabilité. Pour les premières, les chercheurs ont montré que les personnes conformes étaient valorisées sans pour autant que les personnes déviantes soient dévalorisées. Pour les normes enracinées dans la désirabilité, nous faisons l’hypothèse d’un processus inverse, avec plus de dévalorisation des conduites déviantes que de valorisation des conduites conformes. Nous faisons plus précisément l’hypothèse que la civilité est une norme enracinée dans la désirabilité, avec de la dévalorisation en cas de déviance, sans pour autant conduire à de la valorisation en cas de conformisme. Trois études quasi expérimentales, centrées sur l’utilité et la désirabilité de la civilité en milieu professionnel, corroborent globalement notre hypothèse. Les comportements de civilité sont systématiquement plus désirables que les comportements incivils, avec plus de dévalorisation des seconds que de valorisation des premiers. Il est également constaté que les comportements incivils, jugés plus indésirables qu’inutiles, sont davantage ancrés dans la désirabilité que dans l’utilité.
Les facteurs qui entravent l’accès aux soins de santé mentale en contexte migratoire
Authors: Ourhou Abdelaaziz , Bergeul Saïd , Habimana Emmanuel
Published: August 2023

L’accès aux soins est primordial pour éviter la dégradation de la santé mentale des immigrants. Cet article synthétise les obstacles auxquels font face les immigrants en Amérique du Nord et en Europe, ainsi que les perceptions des cliniciens à l’égard de l’intervention interculturelle. L’objectif est d’identifier les conditions et les facteurs qui entravent l’accès aux soins culturellement adaptés en contexte migratoire.
Évaluation des connaissances du réseau d’alerte de première ligne pour les troubles du spectre autistique dans une population nord-africaine (Tozeur, Tunisie)
Authors: Halima Chalghaf , Saoussen Landolsi
Published: August 2023

L’autisme est un handicap lourd. Le manque de données épidémiologiques en Tunisie a rendu difficiles les estimations. Dans la région de Tozeur, il n’y a pas de réseau valable de détection des TSA, ni de registre spécifique pour les autistes. Par cette étude, il a été essayé de dresser l’état des lieux dans la capacité des professionnels de première ligne (PPL) à détecter rapidement et précocement des TSA. Les résultats étaient comparables aux résultats des études réalisées dans les populations du Nigeria; Pakistan; et l’Arabie saoudite. En effet, le personnel de première ligne est peu formé dans le domaine, ce qui rend le diagnostic des TSA très tardif et la prise en charge inefficace. Ceci impose une formation continue du personnel de première ligne pour un diagnostic efficace et précoce. Ceci améliorera la qualité de vie des enfants avec TSA et leurs parents et diminuera les charges financières sur l’état pour la prise en charge des TSA.
Honte, colère et urgence : médiateurs dans la relation entre ruminations et comportements d’agression déplacée
Authors: Henry Anne , Gagnon Jean
Published: August 2023

L’agression déplacée est associée à des ruminations et à des affects négatifs et au trait urgence de l’impulsivité. L’objectif de cette étude est de vérifier empiriquement un modèle sur les médiateurs émotionnels entre ruminations et agressivité déplacée. Deux modèles de médiation en série sont testés. Le premier comprend la honte et la colère. Le second y ajoute l’urgence. L’analyse des données recueillies auprès d’adultes recrutés dans la population générale suggère des effets indirects via la honte et la colère, différents, selon les ruminations. L’urgence serait un médiateur partiel de la relation entre colère et comportements agressifs déplacés, quelles que soient les ruminations.
Transformation of Russia's Migration Policy: stages, features, problems (1989-2023)
Authors: Popova Svetlana Mikhailovna , Yanik Andrey Aleksandrovich , Karpova Svetlana Fyodorovna
Published: August 2023

The article presents the results of the analysis of the fundamental documents of the migration policy of the Russian Federation of the last 30 years, the purpose of which was to identify changes in the fundamental approaches of the authorities in relation to migration and the corresponding legal and institutional changes. An array of normative legal acts of the Russian Federation from 1989 to 2023 (about 100 documents), concepts of migration policy, materials of speeches by the Head of State, meetings of various interdepartmental commissions and high-level profile working groups were used as sources. The study used comparative legal analysis; content analysis; synchronous analysis; general logical approaches and methods. The obtained results allowed us to identify seven stages of the evolution of the Russian migration policy. The boundaries in which the "fluctuation of the course" of migration policy occurs are determined. It is shown that the priorities that the migration policy should correspond to are equally significant, but competing, which leads to inconsistency of the measures taken. It is noted that in recent years, migration policy has been increasingly using adaptive management technologies, which contains risks for long-term goal-setting. The definition of the concept "limits of policy variability" is given. It is concluded that it is necessary to develop a long-term Strategy of the state migration policy, which will take into account the systemic nature of the phenomenon of migration and the multilevel effects that arise as a result of the impact on the migration situation.
Access to healthcare technologies in the context of sanctions and unilateral restrictive measures.
Authors: Malichenko Vladislav Sergeevich , Gadzhieva Albina Omarovna
Published: August 2023

The object of the study is public relations arising from the interaction of international intergovernmental organizations, government agencies, transnational corporations and non-state actors in the framework of ensuring human access to health technologies in the context of unilateral restrictive measures and sanctions. The subject of the study is international legal norms, documents of international organizations, as well as acts of domestic law that form guarantees of ensuring the human right to the highest attainable level of health and access to healthcare technologies. The purpose of the study is to conduct a comprehensive analysis of the practical significance of the application of international legal and domestic mechanisms aimed at minimizing the humanitarian consequences of sanctions and unilateral restrictive measures and expanding access to vital health technologies. The methodology of the study is based on the general scientific method of cognition, including the formal logical and situational method and private law methods, such as comparative, historical and formal legal methods. The article presents an analysis of the importance of health technologies in achieving international goals in the field of development and human health protection, as well as priorities in the implementation of national health strategies. The theoretical aspects of access to healthcare technologies in the context of unilateral restrictive measures are consistently considered as an important element of ensuring international guarantees of human rights protection. The authors present the differences in the normative content of the concepts of "sanctions" and "unilateral restrictive measures" in accordance with international law, as well as a legal assessment of the legitimacy of their application. The article systematizes the consequences of the application of unilateral restrictive measures on the availability of healthcare technologies in various regions of the world, as well as the practice of applying the norms of international and domestic law to overcome them.
The influence of combining professional and educational activities on the stress resistance of adult students
Authors: Zinatullina Azaliia Maratovna
Published: August 2023

In this article, the purpose of the research was to study the impact of combining professional and educational activities on the indicators of stress resistance of adult students in connection with the growing importance of higher education and a large number of competencies in the labor market in order to be a competitive person. Moreover, modern society is undergoing a number of changes that are reflected in various areas of life, which additionally affects the physical and psychological health of a person. Thus, 334 people took part in the study among the respondents: 187 students in the magistracy and 147 not studying at the moment. Techniques for determining stress resistance were used - a test for stress resistance according to the method of K. Schreiner and a test for stress resistance by Holmes and Rage, as well as a method for determining neuropsychic instability "Forecast". The results showed that students in the magistracy have lower stress resistance than adults who do not study, which indicates high workloads associated with the implementation of various types of employment at the same time. For example, many adult learners have families, minor children, dependent parents, other social activities, etc. Thus, the factor of combining professional and educational activities, indeed, affects the instability to stressful experiences, indicating the urgent need to develop adaptive skills of adult respondents.
Ligand bias underlies differential signaling of multiple FGFs via FGFR1
Authors: Karl Kelly , Piccolo Nuala Del , Light Taylor , Roy Tanaya , Dudeja Pooja , Ursachi Vlad-Constantin , Fafilek Bohumil , Krejci Pavel , Hristova Kalina
Published: August 2023

FGFR1 signals differently in response to the fgf ligands FGF4, FGF8 and FGF9, but the mechanism behind the differential ligand recognition is poorly understood. Here, we use biophysical tools to quantify multiple aspects of FGFR1 signaling in response to the three FGFs: potency, efficacy, bias, ligand-induced oligomerization and downregulation, and conformation of the active FGFR1 dimers. We find that the three ligands exhibit distinctly different potencies and efficacies for inducing signaling responses in cells. We further find that FGF8 is a biased ligand, as compared to FGF4 and FGF9. This bias is evident in the phosphorylation of FGFR1 and associated proteins, as well as in FGFR1-mediated functional responses. Our data suggest that the FGF bias arises due to structural differences in the FGF-FGFR1 dimers, which impact the interactions of the FGFR1 transmembrane helices, leading to differential recruitment and activation of the downstream signaling adaptor FRS2. This study expands the mechanistic understanding of FGF signaling during development and brings the poorly understood concept of receptor tyrosine kinase ligand bias into the spotlight.
The involvement of the human prefrontal cortex in the emergence of visual awareness
Authors: Fang Zepeng , Dang Yuanyuan , Ling Zhipei , Han Yongzheng , Zhao Hulin , Xu Xin , Zhang Mingsha
Published: August 2023

Exploring the neural mechanisms of awareness is a fundamental task of cognitive neuroscience. There is an ongoing dispute regarding the role of the prefrontal cortex (PFC) in the emergence of awareness, which is partially raised by the confound between report-and awareness-related activity. To address this problem, we designed a visual awareness task that can minimize report-related confounding. Our results show that saccadic latency is significantly shorter in the aware trials than in the unaware trials. Local field potential (LFP) data from 6 patients consistently show early (200-300 ms) awareness-related activity in the PFC, including event-related potential and high-gamma activity. Moreover, the awareness state can be reliably decoded by the neural activity in the PFC since the early stage, and the neural pattern is dynamically changed rather than being stable during the representation of awareness. Furthermore, the enhancement of dynamic functional connectivity, through the phase modulation at low frequency, between the PFC and other brain regions in the early stage of the awareness trials may explain the mechanism of conscious access. And the spatiotemporal overlap between the awareness-related activity and the inter-regional connectivity in PFC suggested that conscious access and phenomenal awareness may be closely coupled. These results indicate that the PFC is critically involved in the emergence of awareness.