bluuebunny/crossref_metadata_2025 huggingface dataset:
Diminished erythropoietin‐induced erythroid growth in patients with renal anemia is restored by recombinant human erythroid differentiation factor
Authors: Shimizu Takashi , Kawano Yoshifumi , Takaue Yoichi , Kuroda Yasuhiro
Published: February 2007

An examination of the in vitro sensitivity of marrow burst‐forming units for erythroid (BFU‐E) to various concentrations of human recombinant erythropoietin (rEpo) and interleukin‐3 (IL‐3, 20 ng/mL) in serum‐deprived methylcellulose cultures revealed that cells obtained from patients with chronic renal failure showed a defective response to rEpo, particularly at lower concentrations. This poor response was not corrected by the addition of neutralizing antibodies to antitumor necrosis factor‐α or antiinterleukin‐1 α/β. When purified CD34+ cells from these patients were tested for dose‐dependent growth to rEpo, the curve resembled that of normal donors, indicating that there was an intrinsic defect In the patients' progenitor/accessory cell interactions. Using unseparated cells from the patients, we then tested whether the interaction between erythroid differentiation factor (EOF) and rEpo affected BFU‐E growth. Although EDF, either alone or in combination wtth IL‐3, did not affect the growth of BFU‐E in the absence of rEpo, the reduced sensitivity to rEpo in the patients was brought closer to normal limits by the addition of 10 ng/mL EDF to the cultures. The present results may suggest the possibility that, in patients wtth renal anemia, concomitant administration of EDF may increase the therapeutic ratio of rEpo therapy by enhancing the sensitivity of progenitor cells to rEpo, thereby decreasing the therapeutic dose of costly rEpo. © 1994 Wiley‐Liss, Inc.
Increased glutathione in chronic lymphocytic leukemia lymphocytes
Authors: Ferraris Anna Maria , Rolfo Michela , Mangerini Rosa , Gaetani Gian Franco
Published: February 2007

Following reports on a variety of interactions between glutathione (GSH) concentration and clinical parameters in solid tumors, a study was undertaken in order to determine the GSH intracellular content of chronic lymphocytic leukemia (CLL) lymphocytes. The results from a group of 16 patients consecutively studied indicate that B‐CLL cells have twice as much GSH as lymphocytes from normal subjects, suggesting that this measurement may be helpful in the understanding of the metabolic mechanism of the disease and the rationale of therapy. © 1994 Wiley‐Liss, Inc.
Pulmonary hypertension in polycythemia vera
Authors: Nand Sucha , Orfei Emilio
Published: February 2007

Thromboembolic events occur in about 27% of the patients with polycythemia vera and account for 31% of the deaths. These include cerebrovascular accidents, myocardial infarction, peripheral vascular occlusions, pulmonary infarctions, and venous thrombosis. We report two cases with polycythemia vera who presented with pulmonary hypertension in the absence of previous thromboembolic complications of any kind. One patient died suddenly, with evidence of extensive bilateral thrombosis of prelobular pulmonary arteries at autopsy. In the second patient, local thrombosis in the pulmonary vasculature or recurrent silent pulmonary emboli appear to be responsible for the development of pulmonary hypertension. After institution of anticoagulant therapy, he is able to maintain his functional status. The purpose of this report is to alert clinicians to the development of this insidious, but potentially fatal complication in patients with polycythemia vera. © 1994 Wiley‐Liss, Inc.
A four base pair deletion 5′ to the AγT gene is associated not only with decreased expression of the AγT‐globin gene, but also of the Gγ‐globin gene in cis
Authors: Coleman M. B. , Adams J. G. , Steinberg M. H. , Winter W. P.
Published: February 2007

A four base pair deletion 5′ to AγT‐globin gene at positions −222 to −225 has been reported to reduce the expression of this gene. To evaluate the prevalence and effect of this deletion, PCR‐based methods were employed. The deletion had a gene frequency of 0.06 in a sample of African‐American individuals with sickle cell trait, 0.18 in adult African‐Americans with normal Hb AA, and 0.36 in caucasians. Seventy cord blood samples from African‐American newborns with Hb AA were evaluated by both HPLC and PCR. The frequency of the AγT allele was 0.13. The AγT‐globin chain was always present in a lower proportion than the AγI allele (70% of AγI), but the percentage of Aγ‐globin was the same whether or not AγT was present. The total percentage of Hb F, however, was significantly lower in the group with the AγT allele (77.1% vs. 87.4%, P < 0.01). These results indicate that the four base pair deletion is not only associated with reduced expression of the AγT allele, but also of the Gγ allele in cis, further suggesting a possible role of this region in the modulation of the expression of the linked γ‐globin genes. © 1994 Wiley‐Liss, Inc.
Response to radiation in chemotherapy‐refractory monocytoid B‐cell lymphoma: A case report
Authors: Mendenhall Nancy Price , Pawliger David F. , Lynch James W. , Masih Aneal S.
Published: February 2007

A 39‐year‐old man had monocytoid lymphoma including a large retroperitoneal mass, retrocrural and porta hepatic adenopathy with localized pain, but no B symptoms. The tumor did not respond clinically or radiographically to CHOP or mini‐ICE chemotherapy but has responded dramatically to radiotherapy. The patient's disease remains controlled 3 years after treatment. This case documents radioresponsiveness in a chemotherapy‐refractory monocytoid lymphoma. © 1994 Wiley‐Liss, Inc.
Respiratory contamination of polymerase chain reactions by human herpesvirus 6
Authors: Kelley Patrick K. , McClain Kenneth L.
Published: February 2007

Human herpesvirus type 6 DNA derived from human breath was discovered to contaminate PCR reactions during routine reaction preparation. Parallel PCR experiments were conducted in which expiratory secretions were blocked by a surgical mask, while others were performed without any attempt to circumvent respiratory contamination. The experimenter was previously determined to harbor HHV‐6 DNA in the saliva. All reactions in which expiration was obstructed were negative for HHV‐6 DNA via PCR. Reactions in which there was no attempt to obstruct respiratory secretions were positive for HHV‐6 DNA. These data suggest that PCR assays investigating the presence of HHV‐6 may be highly susceptible to contamination from the experimenter leading to false positive results. © 1994 Wiley‐Liss, Inc.
Effect of stem cell factor (c‐kit ligand) on clonogenic leukemic precursor cells: Synergy with other hematopoietic growth factors
Authors: Wu Hua‐Kang , Chiba Shigeru , Hirai Hisamaru , Takaku Fumimaro , Yazaki Yoshio
Published: February 2007

Using clonogenic assay we investigated the effect of stem cell factor (SCF) on the in vitro growth of clonogenic precursor cells from acute myeloid leukemia (AML) and myelodys‐plastic syndromes (MDS) in the presence or absence of recombinant human erythropoietin (rhEpo) or recombinant human granulocyte colony‐stimulating factor (rhG‐CSF). SCF as a single factor did not induce significant colony formation, and even in the presence of rhEpo or rhG‐CSF it very weakly stimulated erythroid colony formation and was rarely capable of inducing myeloid colony formation by clonogenic leukemic cells. In culture dishes supplemented with SCF, both myeloid and erythroid colony formations were dramatically enhanced in MDS, regarding both colony number and size. Cotony‐formation abilities by MDS progenitors were improved following costimulation with SCF and rhEpo. These results suggest that SCF may have a therapeutic role in restoring hematopoiesis in patients with MDS. © 1994 Wiley‐Liss, Inc.
INR reporting in Canadian medical laboratories
Authors: Andrew M. , Brigden M. , Bormanis J. , Cruickshank M. , Geerts W. , Giles A. , Hirsh J. , Hull R. , Johnson J. , Johnston M. , Leclerc J. , Mant M. , Pineo G. , Robinson S. , Robitaille D. , Harding S. Rudledge , Scully M. F. , Turpie A. G. , Vickars L. , Whitman L.
Published: February 2007

A written survey of all licensed medical laboratories in Canada performing coagulation testing was performed to investigate the level of knowledge and overall usage of the INR system for reporting prothrombin time results in medical laboratories. There was an overall response rate of 857 of 1,228 laboratories surveyed. Fifty‐seven percent of responding laboratories utilized some format of INR reporting. The ISi of the individual thromboplastin utilized was known by 89% of laboratories. The IS1 of the thromboplastin utilized was known to be specific for the particular reagent/Instrument combination in 44% of cases. Fifty‐five percent of client physicians preferred PT results to be reported in seconds while 42% desired an INR format. The situation in Canada is similar to the United States in that further education regarding the INR system for PT reporting is required by both medical laboratories and physicians. © 1995 Wiley‐Liss, Inc.
Granulocyte‐Macrophage colony stimulating factor (GM‐CSF) priming in the treatment of elderly patients with acute myelogenous leukemia
Authors: Frenette Paul S. , Desforges Jane F. , Schenkein David P. , Rabson Arthur , Siapack Christopher A. , Miller Kenneth B.
Published: February 2007

Standard intensive induction therapy is tolerated poorly by elderly patients with acute myeloblastic leukemia (AML). We treated 19 elderly patients with AML, including seven with a prior myelodysplastic syndrome (MDS) with a combination of low dose cytarabine, hydroxyurea, and GM‐CSF. The percentage of blasts in S‐phase was evaluated prior to and 24 hr after starting the GM‐CSF infusion. Cell cycle analysis was performed by flow cytometry using propidium iodine staining with fluorescein isothiocyanate‐conjugated monoclonal antibody to the myeloid antigen CD 33.

Seven out of nineteen (37%) achieved a complete remission (CR) and six (31%) a partial remission (PR) for an overall response rate of 68% (13/19). There were three early deaths from infectious complications or organ filure. One patient died from disseminated fungal infection after attaining a PR. The medial overall survival was 9.5 months with a range of 1 to 23+ months. The projected median survival for the patients with de novo AML is greater than 23 months. The percentage of CD 33+ cells in S‐phase increased from a mean of 11.6+/‐2.7 (SEM) pre GM‐CSF to 19.0+/‐3.7 (SEM) post GM‐CSF (P < 0.001). Patients with prior MDS demonstrated a greater increment (post‐pre) in S‐phase activity after GM‐CSF administration (P = 0.02). There was a correlation between the increase in percent of CD 33 + cells in S‐phase and the degree of cytoreduction as determined by the day 14 bone marrow biopsy (r = .78).

The toxicity of the regimen was limited to the hematopoietic system. Sixteen out of nineteen patients (84%) and 12/13 (92%) of the responding patients had bone marrow aplasia on day 14. No patients experienced >grade 2 gastrointestinal toxicity. There was no neurologic or cardiac toxicity.

These data suggest that the combination of hydroxyurea, GM‐CSF, and cytarabine is an effective remission‐induction regimen in elderly patients with AML. © 1995 Wiley‐Liss, Inc.
Cobalamin‐dependent metabolism in chronic myelogenous leukemia determined by deoxyuridine suppression test and the formiminoglutamic acid and methylmalonate excretion in urine
Authors: Gimsing Peter , Hippe Erik
Published: February 2007

The cobalamin metabolism in chronic myelogenous leukemia (CML) was evaluated in 18 newly diagnosed and untreated patients by formiminoglutamic acid (FiGlu) and methyl malonic acid excretion (MMA) tests. A deoxyuridine (dU) suppression test of bone marrow cells was compared in patients with acute myelogenous leukemia (N = 5), myelodysplastic disease (N = 3), untreated pernicious anemia (N = 16), folate deficiency (N = 7), and a hospital reference group without signs of cobalamin or folate deficiency (N = 22).

All had normal MMA excretion but 3 of 15 patients had increased FiGlu excretion. In vitro thymidine uptake in bone marrow cells of CML patients were lower (mean 40 fmol/106 cells) than pernicious anemia patients (115 fmol/106 cells). Methotrexate (MTX) increased the uptake in all cases. Addition of formyl‐THF, methyltetrahydrofolate (methyl‐THF), and pteroylglutamic acid (PGA) tended to normalize the effect of MTX. In pernicious anemia methyl‐THF only decreased the uptake in combination with CN‐Cbl. dU suppression values were significantly higher (6.3%) in CML than in the reference group (4.4%), but significantly lower than in pernicious anemia (41.6%) and folate deficiency (28.5%). The dU suppression values in bone marrow cells of CML patients correlated significantly with the transferrin saturation. In buffy coat cells dU suppression values were even higher (9.3%) than in bone marrow cells of the same CML patients. Addition of folate forms and CN‐Cbl did not change the dU suppression values in CML, as it did in pernicious anemia. MTX increased dU suppression values significantly in all patients, but more in CML (64.5%) than in pernicious anemia (48.6%) and controls (49.8%). The MTX effect was to some extent neutralized by folate analogues with formyl‐THF as the most effective followed by methyl‐THF and lastly PGA. Methyl‐THF also neutralized MTX in pernicious anemia, but its effect was certainly enhanced by addition of CN‐Cbl. Thymidine uptake and dU suppression patterns were not significantly changed in CML after treatment with busulfan for 1 week or in accelerated phase. We concluded that signs of cobalamin or folate deficiency (apart from one patient) cannot be demonstrated in untreated CML. However, dU suppression was significantly increased and more so in circulating myeloid cells than in bone marrow. This indicates a deranged metabolism of deoxynucleotides which is independent of cobalamin and folates, and a difference between bone marrow cells and circulating cells. dU suppression is a valuable indicator of cobalamin deficiency. Preincubation with MTX may assist the diagnosis by demonstrating methyl‐THF‐neutralized thymidine up‐take and dU suppression in combination with CN‐Cbl in patients with pernicious anemia. However, further clinical studies are needed to tell whether the extension of the test is justified by giving additional clinical information. © 1995 Wiley‐Liss, Inc.
Sickle cell anemia and β‐gene cluster haplotypes in Cuba
Authors: Muniz A. , Corral L. , Alaez C. , Svarch E. , Espinosa E. , Carbonell N. , Di Leo R. , Felicetti L. , Nagel R. L. , Martinez G.
Published: February 2007

We have studied 91 patients with SS genotype, 44 children and 47 adults. Excluding the Cameroon and atypical haplotypes, the distribution in the children's sample exhibited 43% Benin, 38% Bantu, and 3% Senegal. In adults, the sample exhibited 46% Benin, 30% Bantu, and 9% Senegal (x2: 13.511, 2 df, P = 0.001). When the whole sample of 198 chromosomes (SS, SC, and S/βthal) is considered, we find that the βs chromosome is linked 51% to the Benin haplotype, 41% with the Bantu, and 8% with the Senegal. After adjusting for the different frequencies of βs in Africa, these numbers would predict the port of origin to be 16% from Atlantic West Africa, 37.3% from Central West Africa, and 46% from Bantu‐speaking Africa. This is in direct contradiction with the historical record that establishes a higher percentage from Bantu‐speaking Africa (55%) and a much lower percentage from Senegal (3.4%). The overall conclusions from these findings is that there is a loss of Bantu haplotypes in sickle cell syndromes in Cuba, particularly among adults, and that there is an excess of Senegal haplotype, also among adults. These differences might reflect the differential survival and severity of the sickle cell disease linked to these haplotypes. © 1995 Wiley‐Liss, Inc.
Autoantibody to factor VIII that has less reactivity to factor Vlll/von Willebrand Factor Complex
Authors: Amano Kagehiro , Arai Morio , Koshihara Kimihito , Suzuki Takashi , Kagawa Kazuhiko , Nishida Yasuharu , Fukutake Katsuyuki
Published: February 2007

To determine the difference in reactivity of factor Vlll (FVIII) inhibitor to FVlll/von Willebrand Factor (vWF) complex and FVlll free of vWF, an autoantibody to FVlll light chain was tested. A patient (1‐3) suffered from autoimmune hemolytic anemia with autoantibody to FVIII. Epitope specificity of the patient's IgG (1‐3 IgG) was shown to be the C2 domain of FVlll light chain (2170‐2332) by Western blotting using recombinant FVlll deletions expressed in Escherichia coli. The inhibitory effect on FVlll procoagulant activity (VIII :C) of 1‐3 lgG was tested against a conventional FVlll concentrate; Haemate P, a monoclonal antibody‐purified FVlll concentrate; Hemofil M, and a recombinant FVlll (rFVIII); Kogenate. 1‐3 lgG showed only 1.3 BU/mgIgG for Haemate P, in contrast to 20 BU/mglgG for both Hemofil M and Kogenate. The ratio of VIII:C/vWF:Ag in Haemate P and Hemofil M was 1/3.43 and 1/0.01, respectively, while Kogenate did not contain vWF. The inhibitory effect of the 1‐3 IgG was then compared with Kogenate and its complex with vWF. The inhibitory effect was decreased against the rFVlll by forming a complex with vWF. from 22 BU/mglgG to o.5 BU/mgIgG. Fab from the 1‐3 IgG had the same effect. In addition, vWF showed a protective effect on FVlll inactivation by the 1‐3 IgG in a dose dependent manner. Fifty‐nine percent of residual VIII:C was retained in the presence of 8 U/ml of vWF after 1 hr incubation with 1‐3 lgG. These results suggested that vWF could compete with the 1‐3 IgG for binding to FVIII. © 1995 Wiley‐Liss, Inc.
Cytokine profile in acute myelofibrosis associated with aggressive large granular lymphocyte leukemia
Authors: Dalal Bakul I. , Keown Paul A. , Paraskevas Frixos , Williams Gaynor , Johnston James B.
Published: February 2007

We report a patient with acute large granular lymphocyte (LGL) leukemia, presenting as acute myelofibrosis (AMF). The leukemic cells were immature T‐cells (CD5+, CD7+, CD16−, CD56−, CD57−, and CD41−), had monosomy 7, and secreted large amounts of Transforming Growth Factor‐β1(TGF‐β1). The serum levels of interleukins (IL)‐2, ‐2R, ‐6 and ‐8 were elevated, while the IL‐1<β, IL‐4, and tumor necrosis factor‐α were normal. © 1995 Wiley‐Liss, Inc.
Dexamethasone in the treatment of meningeal leukemia
Authors: Gómez‐Almaguer David , González‐Llano Oscar , Montemayor Jorge , Jaime‐Pérez José C. , Galindo Cesar
Published: February 2007

To determine if dexamethasone has a role in the treatment of meningeal leukemia, 8 consecutive patients with acute lymphoblastic and signs or symptoms of CNS were included in the study. After the confirmation of leukemic blast cells on cerebrospinal fluid, they received intrathecal and IV dexamethasone; 3 days later the patients received “triple” intrathecal chemotherapy with dexamethasone, methotrexate and cytarabine, and the spinal fluid was studied again. All patients had good clinical response and 7 out of the 8 patients showed reduction on the CSF cell count after the use of dexamethasone alone. The results suggest that dexamethasone is a lympholytic agent that could play a more active role in the prevention and therapy of meningeal leukemia and should be preferred over hydrocortisone in the so called “triple” intrathecal chemotherapy for the prevention and treatment of CNS leukemia. © 1995 Wiley‐Liss, Inc.
Hb lulu island (α2β2107[G9]Gly→Asp)‐β°‐thalassemia (codon 15; TGG → TAG), a form of thalassemia intermedia
Authors: Gray G. R. , Manson H. E. , Gu L‐H. , Ye. Leonova J. , Huisman T. H. J.
Published: February 2007

Hb Lulu Island [β107(G9)Gly → Asp] was discovered in an East Indian female who carried a common β°‐thalassemia allele, i.e., codon 15, TGG → TAG (is a stop codon) in trans. Both abnormalities were detected through sequencing of the amplified β‐globin genes and were confirmed by hybridization with 32P‐labeled probes. Hb Lulu Island is mildly unstable with a borderline decrease in oxygen affinity; its instability is less severe than that of Hb Burke or β107(G9)Gly → Arg. The compound heterozygosity expresses as a thalassemia intermedia with moderate anemia, a variable need for blood transfusions, Heinz body formation, and a red cell morphology which is typical for such a condition. The level of HbA2 was greatly increased (6.5–7.0%) as was the δ chain level (12% of total non‐α) probably because of the instability of Hb Lulu Island and the decreased ability of the βx chain to form dimers with the normal α chain.
Clinical and histological features retain their prognostic impact under interferon therapy of CML: A pilot study
Authors: Thiele Juergen , Kvasnicka Hans Michael , Niederle Norbert , Kloke Otto , Schmidt Marcus , Lienhard Heiko , Zirbes Thomas , Meuter Raoul Boris , Leder Lutz Dietrich , Fischer Robert
Published: February 2007

In 55 patients with Ph1+ CML under interferon (IFN) monotherapy, an immunohistochemical and morphometric study on pretreatment bone marrow biopsies was performed to evaluate the prognostic impact of clinical as well as histological disease features. For identification of megakaryocytes we used the PAS stain and CD61 to calculate the subtraction of precursors (pro‐ and megakaryoblasts). Demonstration of macrophages and their different subsets was carried out by PG‐M1 (CD68) and the GSA‐I lectin. The erythroid precursors were stained by Ret40f (anti‐glycophorin C). Density of argyrophilic (reticulin plus collagen) fibers was determined by applying Gomori's silver impregnation method. Clinical variables like state of hematological response to IFN administration, age, spleen and liver size, myeloblasts plus promyelocytes, basophils as well as basophils and eosinophils exerted a predictive capacity by univariate statistical analysis. However, when entering these factors into previously published risk models, i.e., the so‐called Sokal score and its modifications, to assess subgroups with different survival patterns or relative risk groups, a clear‐cut discrimination was not feasible. Bone marrow features of prognostic value consisted of megakaryocytes and their precursors, fibers, and pro‐ and erythroblasts. Only when including histological variables into a formerly reported Cox model, could a significant separation of patients into the different categories or relative risk groups be computated. In conclusion, the present data emphasize the prognostic impact of histological parameters to be considered in all clinical trials on CML.
In vitro and in vivo myelotoxicity of CAI to human and murine hematopoietic progenitor cells
Authors: Volpe Donna A. , Cole Kristina , Sandeen Mary Ann , Kohn Elise C.
Published: February 2007

Carboxyamido‐triazole (CAI), an agent that targets calcium‐sensitive signal transduction pathways, has both antiproliferative and antimetastatic properties. The objective of this study was to evaluate the myelotoxicity of CAI to normal human and murine hematopoietic cells. In vitro toxicity of CAI was determined by inhibition of myeloid [colony‐forming unitgranulocyte/macrophage (CFU‐gm)] and erythroid [burst‐forming unit‐erythroid (BFU‐e)] colony formation in clonal assays. The effects of oral CAI on CD2F1 mouse marrow and splenic cellularity, marrow progenitor content, and peripheral blood cell counts were assessed in relation to plasma CAI levels. In vitro, CAI caused a concentration‐dependent inhibition of CFU‐gm and BFU‐e colonies following continuous drug exposure. Murine CFU‐gm and BFU‐e were inhibited > 90% by 10 and 15 μg/mL CAI, respectively. However, suppression of human CFU‐gm and BFU‐e did not exceed 65% at the same concentrations. In vivo, CAI reduced the number of CFU‐gm and BFU‐e per femur after the initial dose and through day 4. Variations in colony inhibition paralleled changes in CAI plasma concentrations. While colony inhibition increased in vitro with escalating drug concentrations, this was not observed in vivo with additional CAI doses. The low toxicity of CAI in vivo combined with the significant difference between toxicity for human and mouse progenitors in vitro suggests a relatively low adverse potential to the bone marrow for this new signal transduction inhibitory agent.
High‐density lipoprotein fails to inhibit serotonin‐induced activation of blood platelets
Authors: Pfennig Olaf , Zhao Bin , Frye Sabine , Dierichs Rolf
Published: February 2007

High‐density lipoprotein (HDL) of 100–400 μg/ml did not prevent morphological alterations of human blood platelets treated with serotonin (1–5 μM). Highly concentrated HDL (1,200 μg/ml) appeared to activate platelets in vitro. These findings indicate that whole HDL may not inhibit agonist‐induced platelet activation.
A single episode of neonatal seizures permanently alters glutamatergic synapses
Authors: Cornejo Brandon J. , Mesches Michael H. , Coultrap Steven , Browning Michael D. , Benke Timothy A.
Published: February 2007

Objective

The contribution of seizures to cognitive changes remains controversial. We tested the hypothesis that a single episode of neonatal seizures (sNS) on rat postnatal day (P) 7 permanently impairs hippocampal‐dependent function in mature (P60) rats because of long‐lasting changes at the synaptic level.

Methods

sNS was induced with subcutaneously injected kainate on P7. Learning, memory, mossy fiber sprouting, spine density, hippocampal synaptic plasticity, and glutamate receptor expression and subcellular distribution were measured at P60.

Results

sNS selectively impaired working memory in a hippocampal‐dependent radial arm water‐maze task without inducing mossy fiber sprouting or altering spine density. sNS impaired CA1 hippocampal long‐term potentiation and enhanced long‐term depression. Subcellular fractionation and cross‐linking, used to determine whether glutamate receptor trafficking underlies the alterations of memory and synaptic plasticity, demonstrated that sNS induced a selective reduction in the membrane pool of glutamate receptor 1 subunits. sNS induced a decrease in the total amount ofN‐methyl‐D‐aspartate receptor 2A and an increase in the primary subsynaptic scaffold, PSD‐95.

Interpretation

These molecular consequences are consistent with the alterations in plasticity and memory caused by sNS at the synaptic level. Our data demonstrate the cognitive impact of sNS and associate memory deficits with specific alterations in glutamatergic synaptic function. Ann Neurol 2007
Synthesis, Structure and Properties of the High‐Pressure Modifications of the Ternary Compounds LnPtSn (Ln: La, Pr, Sm).
Authors: Riecken Jan F. , Rodewald Ute Ch. , Heymann Gunter , Rayaprol Sudhindra , Huppertz Hubert , Hoffmann Rolf‐Dieter , Poettgen Rainer
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Energetics of Cobalt Phosphate Frameworks: α, β, and Red NaCoPO4.
Authors: Le So‐Nhu , Eng Hank W. , Navrotsky Alexandra
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Facile High‐Yield Solvothermal Route to Tin Phosphide Sn4P3.
Authors: Kovnir Kirill A. , Kolen'ko Yury V. , Ray Sugata , Li Jinwang , Watanabe Tomoaki , Itoh Mitsuru , Yoshimura Masahiro , Shevelkov Andrei V.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Structure, Magnetic Susceptibility and Moessbauer and Raman Spectroscopies of the New Oxyphosphate Fe0.50TiO(PO4).
Authors: Benmokhtar S. , El Jazouli A. , Chaminade J. P. , Gravereau P. , Wattiaux A. , Fournes L. , Grenier J. C. , Waal. D. Waal. D.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ag2CuMnO4: A New Silver Copper Oxide with Delafossite Structure.
Authors: Casan‐Pastor Nieves , et al. et al.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Application of Organolithium and Related Reagents in Synthesis. Part 31. Effective Conversion of 3‐Arylphthalides into 2‐(1‐Aryl‐3‐oxo‐4‐alkoxycarbonylbutyl)benzoic Acids.
Authors: Bieniek Adam , Kulikiewicz Krystyna K. , Bartczak Monika M.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Solvent‐Free Bromination of 1,3‐Diketones and β‐Keto Esters with NBS.
Authors: Pravst Igor , Zupan Marko , Stavber Stojan
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Halide‐Free Ethylation of Phenol by Multifunctional Catalysis Using Phosphinite Ligands.
Authors: Carrion M. Carmen , Cole‐Hamilton David J.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regiospecific Phenyl Esterification to Some Organic Acids Catalyzed by Combined Lewis Acids.
Authors: Roy H. N. , Al Mamun A. H.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Chiral Hydroxylated Cyclopentanones and Cyclopentanes.
Authors: Niidu Allan , Paju Anne , Eek Margus , Mueuerisepp Aleksander‐Mati , Pehk Tonis , Lopp Margus
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Promoted Cross‐Coupling of Acid Chlorides with Arylboronic Acids: A Convenient Method for Preparing Aromatic Ketones.
Authors: Polackova Viera , Toma Stefan , Augustinova Iveta
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Efficient and General Method for the Ring‐Opening of Aziridines with Various Nucleophiles in DMSO.
Authors: Wu Jie , Sun Xiaoyu , Sun Wei
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Structural Study of Tetrahydroindazolones.
Authors: Claramunt Rosa M. , Lopez Concepcion , Perez‐Medina Carlos , Pinilla Elena , Torres M. Rosario , Elguero Jose
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Synthesis of Aryl and Heteroaroyl‐Substituted Hydroxypyrazolines from the Reactions of β‐Alkoxyvinyl Trichloromethyl Ketones with Heteroarylhydrazides.
Authors: Bonacorso Helio G. , Oliveira Marli R. , Costa Michelle B. , Drekener Roberta L. , da Silva Leticia B. , Zanatta Nilo , Martins Marcos A. P.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Facile Synthesis of 2‐Alkylthio‐5,5‐dimethyl‐4H‐imidazol‐4‐ones.
Authors: Yuan Ju‐Zhen , Wei Jia‐Jia , Ding Ming‐Wu
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Discovery and Design of Benzimidazolone Based Inhibitors of p38 MAP Kinase.
Authors: Moss Neil , et al. et al.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N,N,N′,N′‐Tetrabromobenzene‐1,3‐disolfonamide (TBBDS) as an Efficient Promoter for One‐Pot Conversion of N‐Arylglycines to Sydnones in the Presence of NaNO2/Ac2O under Neutral Conditions.
Authors: Azarifar Davood , Ghasemnejad‐Bosra Hassan , Ghorbani‐Vaghei Ramin , Tajbaksh Mahmood
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rapid Synthesis of 4‐Benzylidene and 4‐[Bis‐(4‐methoxyphenyl)‐methylene]‐2‐substituted Phenyl‐Benzopyrans as Potential Selective Estrogen Receptor Modulators (SERMs) Using McMurry Coupling Reaction.
Authors: Gupta Atul , Dwivedy Anila , Keshri Govind , Sharma Ramesh , Balapure Anil Kumar , Singh Man Mohan , Ray Suprabhat
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Benzo[g]isochromenes Through Photo‐Dehydro‐Diels—Alder Reaction.
Authors: Wessig Pablo , Mueller Gunnar , Herre Robert , Kuehn Andreas
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of the 7‐Azaindole (1H‐Pyrrolo[2,3‐b]pyridine) Analogous to Cannabimimetic JHW 200.
Authors: Gluszok Sebastien , Goossens Laurence , Depreux Patrick , Barbry Didier , Henichart Jean‐Pierre
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Coupling of β‐Cyanocarbene‐chromium Complexes with 2‐Alkynylbenzoyl Derivatives: A [5 + 5]‐Cycloaddition Approach to Phenanthridines.
Authors: Ghorai Binay K. , Duan Shaofeng , Jiang Delu , Herndorn James W.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Purines Bearing Functionalized C‐Substituents by the Conjugate Addition of Nucleophiles to 6‐Vinylpurines and 6‐Ethynylpurines.
Authors: Kuchar Martin , Pohl Radek , Votruba Ivan , Hocek Michal
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Highly Functionalized Imidazo[1,5‐a]pyrazines.
Authors: Trcek Tomaz , Vercek Bojan
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Catalyzed Cross‐Coupling Reactions of Diazine N‐Oxides with Aryl Chlorides, Bromides, and Iodides.
Authors: Leclerc Jean‐Philippe , Fagnou Keith
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Entrapment of a Dirhodium Tetracarboxylate Unit Inside the Aromatic Bowl of a Calix[4]arene: Unique Catalysts for C—H Amination.
Authors: Brodsky Benjamin H. , Du Bois J.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cyclohexanedione Bisaminals as Intermediates for Cyclen, Homocyclen, and Cyclam Synthesis.
Authors: Prokhorov Anton , Le Bris Nathalie , Bernard Helene , Claudon Geraldine , Handel Henri
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 1,2,4‐Trioxepanes via Application of Thiol‐Olefin Co‐Oxygenation Methodology.
Authors: Amewu Richard , Stachulski Andrew V. , Berry Neil G. , Ward Stephen A. , Davies Jill , Labat Gael , Rossignol Jean‐Francois , O'Neill Paul M.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of Antheliolide A.
Authors: Mushti Chandra Sekhar , Kim Jae‐Hun , Corey E. J.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bioactive Diterpenes from the Mangrove Avicennia officinalis Linn.
Authors: Subrahmanyam C. , Kumar S. Ratna , Reddy G. Damodar
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of the Chlorinated Marine Natural Product Dysamide B.
Authors: Durow Amanda C. , Long G. Cliona , O'Connell Susan J. , Willis Christine L.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Generation of an S‐Peptide via an N—S Acyl Shift Reaction in a TFA Solution.
Authors: Nakamura Ken'ichiroh , Sumida Megumi , Kawakami Toru , Vorherr Thomas , Aimoto Saburo
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chiral Stability of Phosphonium‐Type Amino Acid Ionic Liquids.
Authors: Fukumoto Kenta , Kohno Yuki , Ohno Hiroyuki
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Sugar‐Quinoline Fluorescent Chemosensor for Selective Detection of Hg2+ Ion in Natural Water.
Authors: Ou Shengju , Lin Zhihua , Duan Chunying , Zhang Haitao , Bai Zhiping
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Concise Synthesis of the (.+‐.)‐Nb‐Desmethyl‐meso‐chimonanthine.
Authors: Menozzi Candice , Dalko Peter I. , Cossy Janine
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Silver‐Catalyzed Asymmetric Synthesis of 2,3‐Dihydrobenzofurans: A New Chiral Synthesis of Pterocarpans.
Authors: Jimenez‐Gonzalez Leticia , Garcia‐Munoz Sergio , Alvarez‐Corral Miriam , Munoz‐Dorado Manuel , Rodriguez‐Garcia Ignacio
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Isokibdelones: Novel Heterocyclic Polyketides from a Kibdelosporangium sp.
Authors: Ratnayake Ranjala , Lacey Ernest , Tennant Shaun , Gill Jennifer H. , Capon Robert J.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of (+)‐cis‐Sylvaticin: Double Oxidative Cyclization Reactions Catalyzed by Osmium.
Authors: Donohoe Timothy J. , Harris Robert M. , Burrows Jeremy , Parker Jeremy
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
1‐Aryltetralin Privileged Structure‐Based Libraries: Parallel Synthesis of N‐Aryl and N‐Biaryl γ‐Lactam Lignans.
Authors: Dorbec Matthieu , Florent Jean‐Claude , Monneret Claude , Rager Marie‐Noelle , Bertounesque Emmanuel
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of the Mycolactone Core by Ring‐Closing Metathesis.
Authors: Alexander Matthew D. , Fontaine Shaun D. , La Clair James J. , DiPasquale Antonio G. , Rheingold Arnold L. , Burkart Michael D.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Carbohydrate Containing Complex Natural Compounds
Authors: Toshima Kazunobu
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
They Came from the Deep. Syntheses, Applications, and Biology of Ladderanes
Authors: Nouri Dustin H. , Tantillo Dean J.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Novel Antimalarial Compound Dioncophylline C Forms a Complex with Heme in Solution
Authors: Schwedhelm Kai F. , Horstmann Martin , Faber Johan H. , Reichert Yana , Bringmann Gerhard , Faber Cornelius
Published: February 2007

A structural model of the complex formed between the novel antimalarial compound dioncophylline C (DioC) and its presumed target ferriprotoporphyrin IX heme (FPIX) is presented. The complex structure was calculated with molecular dynamics (MD) simulations using intermolecular distance restraints between DioC and the iron center in FPIX, determined from NMR paramagnetic relaxation. Besides the spin state of the iron and longitudinal relaxation rates of hydrogen nuclei in DioC, the effective correlation time of paramagnetic relaxation was determined from NMR measurements at three different magnetic field strengths. The derived structural model shows high similarity to complexes formed by FPIX and antimalarials of the quinoline family (chloroquine, quinine, quinidine, and amodiaquine). The conformation of DioC is sterically stabilized by a water molecule coordinated to iron in FPIX. This structural feature may provide an important hint at possibilities for a further optimization of novel naphthylisoquinoline alkaloid (NIQ) antimalarial drugs.
Modified lipoproteins as contrast agents for imaging of atherosclerosis
Authors: Frias Juan C. , Lipinski Michael J. , Lipinski Shawn E. , Albelda M. Teresa
Published: February 2007

The ability to detect and characterize atherosclerosis with targeted contrast agents may enable initiation of therapy for atherosclerotic lesions prior to becoming symptomatic. Since lipoproteins such as high‐density lipoprotein (HDL) and low‐density lipoprotein (LDL) play a critical role in the regulation of plaque biology through the transport of lipids into and out of atherosclerotic lesions, modifying HDL and LDL with radioisotopes for nuclear imaging, chelates for magnetic resonance imaging (MRI) or other possible contrast agents for computed tomography imaging techniques may aid in the detection and characterization of atherosclerosis. This review focuses on the literature employing lipoproteins as contrast agents for imaging atherosclerosis and the feasibility of this approach. Copyright © 2007 John Wiley & Sons, Ltd.
Channel modeling of nondirected wireless infrared indoor diffuse link
Authors: Hayasaka Naoki , Ito Takeshi
Published: February 2007

This paper discusses the modeling and broadband design of an indoor infrared wireless communication channel consisting of a nondirected diffusion system. The property of the nondirected diffuse link is analyzed by the ray tracing technique and the modified Monte Carlo method. The physical parameters are directly related to the impulse response of the link and are modeled by a gamma probability density function. The impulse response model and a simulation indicate that it is effective for the broadband link to narrow the radiation angle of the optical source and to expand the receiver field of view to match the ceiling area of the room. © 2007 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 90(6): 9–19, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.20352
Performance evaluation of 6000‐A‐class superconducting field windings for 600‐MW‐class superconducting generators
Authors: Maeda Susumu , Shimohata Kenji , Kodera Itsuo , Sano Hideaki , Izumi Akifumi
Published: February 2007

Superconducting generators have many advantages such as increasing generator efficiency and improving power system stability. In Japan, a national project has been conducted since 2000 which is aimed at the development of fundamental technologies required for high‐output‐density and large‐capacity superconducting generators. This paper describes the results of this project, focusing on 6000‐A‐class field winding development. Copyright © 2004 Wiley Periodicals, Inc.

A superconducting generator with a high output density and a large capacity has inherent factors that decrease superconducting stability. These are: (1) increase in the magnetic field in the winding which is caused by the increase in winding current density and (2) difficulty in fabricating windings which increases as a conductor diameter becomes larger. To secure the stability, we adopted a higher‐copper‐content conductor and a design that increases winding fixing pressure, along with devising a winding method that accommodates larger conductor diameter. These improvements were applied to a partial model of a 600‐MW field winding. Test results of the model showed good stability, indicating that design and fabrication technique for a 6000‐A‐class superconducting field winding has been successfully evaluated. © 2007 Wiley Periodicals, Inc. Electr Eng Jpn, 159(2): 7– 18, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20332