bluuebunny/crossref_metadata_2025 huggingface dataset:
Everybody’s Holocaust? Tova Reich’s Satirical Approach to Shoah Business and the Cult of Victimhood
Authors: Kolář Stanislav
Published: September 2019

This paper sets out to demonstrate the changes that post-Holocaust fiction has been undergoing since around the turn of the new millennium. It analyzes the highly innovative and often provocative approaches to the Holocaust and its memory found in Tova Reich’s novel My Holocaust—a scathing satire on the personal and institutional exploitation of Holocaust commemoration, manifested in the commodification of the historical trauma in what has been termed “Shoah business”. The novel can be seen as a reaction to the increasing appropriation of the Holocaust by popular culture. This paper focuses on Reich’s critical response to the cult of victimhood and the unhealthy competition for Holocaust primacy, corresponding with the growth of a “victim culture”. It also explores other thematic aspects of the author’s satire—the abuse of the term “Holocaust” for personal, political and ideological purposes; attempts to capitalize on the suffering of millions of victims; the trivialization of this tragedy; conflicts between particularists and universalists in their attitude to the Shoah; and criticism of Holocaust-centered Judaism. The purpose of this paper is to show how Tova Reich has enriched post-Holocaust fiction by presenting a comic treatment of false victimary discourse, embodied by a fraudulent survivor and a whole gallery of inauthentic characters. This paper highlights the novel’s originality, which enables it to step outside the frame of traditional Holocaust fiction.
The Internal Structural Evolution of Calderas: Results from 3D Discrete Element Simulations
Authors: Hardy Stuart
Published: September 2019

The structural evolution of calderas is a key issue in volcanology and has profound implications for hazard analysis and the exploitation of geothermal energy and hydrothermal ores. However, their internal geometry at depth and the detailed fault and fracture distribution are unclear and debated. In order to better constrain the internal structural evolution of calderas, I have developed a 3D discrete element model of a frictional cover undergoing piston-like subsidence at its base, simulating magma chamber deflation and cover collapse. I examine two piston geometries, simulating magma chambers with roofs that are circular and rectangular in plan view, to investigate patterns of faulting and subsidence in three dimensions. In both models a complex arrangement of normal and reverse faults accommodates deeper subsidence at higher structural levels. Bell- to cone-shaped, outward-dipping ring faults are consistently the first structures to develop; these faults propagate upwards from the piston edges towards the surface. Later caldera growth is mainly the result of movement on vertical, or steeply inward-dipping, normal ring faults which enclose the earlier reverse faults. As a result, all calderas widen, in terms of their surface expression, with time. The final stage of caldera development includes significant collapse of the caldera walls and transport of this material towards the caldera center. The results confirm that the evolutionary patterns/stages proposed from 2D numerical and analogue models can be generalized to three dimensions, although significant differences between long- and short-axis geometries do occur when the piston is elongate. Compared to 2D simulations, however, 3D results show the geometric complexity of ring faulting, with variations in strain and fault activity at various stages of development demonstrating that often a simple, continuous ring fault structure is not developed.
Abiotic Stress Effects on Performance of Horticultural Crops
Authors: Francini Alessandra , Sebastiani Luca
Published: September 2019

The yield and quality of horticultural crops mainly depend on genotype, environmental conditions, and cultivation management. Abiotic stresses, such as adverse environmental conditions, can strongly reduce crop performance, with crop yield losses ranging from 50% to 70%. The most common abiotic stresses are represented by cold, heat, drought, flooding, salinity, nutrient deficiency, and high and low light intensities, including ultraviolet radiation. These abiotic stresses affect multiple physiological and biochemical processes in plants. The ability of plants to face these stresses depends on their adaptation aptitude, and tolerant plants may express different strategies to adapt to or avoid the negative effects of abiotic stresses. At the physiological level, photosynthetic activity and light-use efficiency of plants may be modulated to enhance tolerance against the stress. At the biochemical level, several antioxidant systems can be activated, and many enzymes may produce stress-related metabolites to help avoid cellular damage, including such compounds as proline, glycine betaine, amino acids, etc. This special issue gathers eight papers; three are reviews and five are research papers. Two reviews are focused on the application of appropriate agronomic strategies for counteracting the negative effects of abiotic stresses. The third review is based on ornamental plant production under drought stress conditions and the effect on their ornamental quality. The research papers report the effect of climate change on crop development, yield, and quality. Abiotic stresses have been proven to reduce crop performance and yield. Research studies are essential for understanding the key adaptation strategies of plants that can be exploited for improving the crop stress tolerance.
Glycated Hemoglobin in the Diagnosis of Diabetes Mellitus in a Semi-Urban Brazilian Population
Authors: do Vale Moreira Nayla Cristina , Montenegro Renan M. , Meyer Haakon E. , Bhowmik Bishwajit , Mdala Ibrahimu , Siddiquee Tasnima , Oliveira Fernandes Virgínia , Hussain Akhtar
Published: September 2019

The study evaluated glycated hemoglobin (HbA1c) as a diagnostic tool for diabetes and pre-diabetes in the Brazilian population. Further, the homeostasis model assessment of insulin resistance (HOMA-IR) was also examined against HbA1c values to identify the most suitable cut-off points for HOMA-IR to predict the risk of diabetes. A cross-sectional study was conducted among 714 randomly selected subjects. HbA1c, fasting, and 2 h plasma glucose values were measured. Insulin resistance estimates were calculated with HOMA-IR. The receiver operating characteristic curve assessed HbA1c performance. The adjusted prevalence rate of diabetes mellitus was 14.7%, and pre-diabetes 14.2%. The optimal HbA1c cut-off value was ≥6.8% for the diagnosis of diabetes, and ≥6.0% for pre-diabetes. The area under the curve using HbA1c was 0.85 (95% CI: 0.80–0.90) for detecting diabetes and 0.61 (95% CI: 0.55–0.67) for pre-diabetes. The optimal HOMA-IR cut-off value was 2.06 for HbA1c at 6.8%. The HbA1c cut-off value of ≥6.8% may be suitable for diagnosing diabetes in the Brazilian population. Our results do not support the use of HbA1c to diagnose pre-diabetes. A HOMA-IR cut-off point of 2.06 was a sensitive marker to assess the risk of diabetes.
Deaths in Australia from Work-Related Heat Stress, 2000–2015
Authors: Gun Richard
Published: September 2019

The infrequency of deaths from work-related heat stress may be due to self-pacing, whereby workers adjust their work rate in response to thermal discomfort. Thirteen cases attributed after coronial investigation to work-related heat stress were studied to evaluate the causal contribution of environmental and personal risk factors. Meteorological records and coronial records were examined to estimate environmental and metabolic heat loads and to identify any personal risk factors likely to have contributed to death. Seven deaths occurred in workers within one week of hiring, demonstrating not only the importance of acclimatisation but also the likelihood of compromised self-pacing in recently-hired workers. Personal risk factors identified included intercurrent illness, cardiovascular disease and obesity. Four deaths occurred following indoor work, where the probable critical risk parameter was low air velocity. Cerebral and pulmonary oedema were reported in some autopsy reports, and uncal herniation was found in one case. Modified work rates and close supervision are essential in recently-hired workers. The risk of death from raised intracranial pressure suggests the need for specific remediation of cerebral oedema in hyperthermic individuals.
A Study of Perceived Nature, Shade and Trees and Self-Reported Physical Activity in Denver
Authors: Tabatabaie Sara , Litt Jill S. , Carrico Amanda
Published: September 2019

(1) Background: Current evidence on the association between greenery and physical activity (PA) remains inconsistent. Most studies on this association use objective measures of greenness, which do not reveal people’s perceptions of greenness in neighborhoods, or the role of quality components of greenness, such as shade, trees, and the presence of nature on this association. (2) Methods: Drawing on data from the Neighborhood Environment and Health Survey—a cross-sectional population-based survey of Denver residents in 2007—we examined which measures of greenness (perceived and objective) correlated with the self-reported PA. We also assessed how components of perceived greenness, shade, trees and the presence of nature, correlated with PA. (3) Results: Perceived greenness, reflecting perception of trees, shade and the presence of nature, was positively associated with reported moderate–vigorous PA. Conclusion: Findings provide evidence that quality aspects of greenness affect people’s perception of the neighborhood in a way that relates to PA. The individual contributions of shade, trees, and the presence of nature in this association should be analyzed in future studies. Understanding the link between shade and trees and PA has implications for how to plan for walkability and sun safety at the neighborhood scale.
The Hospital Patient Safety Culture Survey: Reform of Analysis and Visualization Methods
Authors: Jeong Heon-Jae , Lee Wui-Chiang , Liao Hsun-Hsiang , Chu Feng-Yuan , Chen Tzeng-Ji , Wang Pa-Chun
Published: September 2019

Understanding the topography of hospital safety culture is vital for developing, implementing, and monitoring the effectiveness of tailored safety programs. Since 2009, the Chinese version of the Safety Attitudes Questionnaire (SAQ-C) has been introduced and administered to providers in many Taiwanese hospitals. The percentage of SAQ respondents who demonstrate attitudinal agreement within each of the SAQ domains, the percent agreement (PA) score, is used worldwide as the main parameter of safety culture surveys. However, several limitations within PA scoring have been identified. Our study sought to improve scoring methodology and develop a new graph layout for cultural topography presentation. A total of 37,163 responses to a national SAQ-C administration involving 200 Taiwan hospitals were retrospectively analyzed. To understand the central tendency and spread of safety culture scores across all participating hospitals, the median and interquartile range (IQR) of individual respondent’s SAQ-C scores by its domain were calculated, plotted, and named “Jeong & Lee plot”. Because of space limitation, we showed teamwork domain only. Study results denote limitations in the current PA scoring scheme, suggest SAQ analysis modification, and introduce a visualization graph layout that can provide richer information about safety culture dissemination than that available from currently utilized tools.
Homicide Profiles Based on Crime Scene and Victim Characteristics
Authors: Pecino-Latorre María del Mar , Pérez-Fuentes María del Carmen , Patró-Hernández Rosa María
Published: September 2019

One of the current trends in homicide research includes developing works based on scientific study and empirical evidence, which offer conclusions that can be used in an operational manner during police investigations. The objective of this study was to identify homicide characteristics from behaviors carried out on the crime scene and victim characteristics associated with those of the perpetrators of these crimes in Spain. The sample consisted of 448 homicide cases from the database of the Homicide Revision Project led by the Office of Coordination and Studies of the Secretary of State and Security. After creating six classification tree models, it was found that the modus operandi of the aggressor and the victim characteristics may permit hypothesizing about the demographic characteristics of the perpetrator (gender, age, and country of origin), his/her criminal record, and the type of relationship with the victim. Furthermore, the importance of the study of victimology during a criminal investigation is highlighted, as it may indirectly offer information about the potential perpetrator. The findings of this study suggest that criminal profiling contributes notably to the decision-making process to establish more rigorous suspect prioritization, improve the management of human resources and materials, and increase the efficiency of criminal investigations.
The Power of Recognition: A Qualitative Study of Social Connectedness and Wellbeing through LGBT Sporting, Creative and Social Groups in Ireland
Authors: Ceatha Nerilee , Mayock Paula , Campbell Jim , Noone Chris , Browne Kath
Published: September 2019

The broad research consensus suggesting substantial vulnerabilities among lesbian, gay, bisexual and transgender (LGBT) communities may fail to recognize the protective factors available to these populations. The sparse literature on mental health promotion highlights the importance of understanding strengths-based community approaches that promote LGBT wellbeing. Informed by the Ottawa Charter for Health Promotion, underpinned by Honneth’s Theory of Recognition, this paper outlines the findings of a qualitative Irish study on LGBT social connectedness through a diverse range of sporting, creative and social interests. Ten in-depth interviews were conducted with 11 people (including one couple) who self-identified as lesbian (5), gay (4), bisexual (1) and transgender (1) aged between 22 and 56 years. A university Research Ethics Committee granted approval. The data were transcribed and coded using thematic analysis, enhanced through a memo-writing approach to reflexivity. The theme of ‘connecting’ emphasized the shared nature of activities, with like-minded others through groups established by, and for, LGBT communities. Messages from the study reinforce the central role of LGBT communities in the promotion of mental health and social wellbeing, with important policy and practice implications. This requires the contextualization of the contribution of LGBT communities within understandings of social justice, identity and recognition.
Distribution, Ecological Risk Assessment, and Bioavailability of Cadmium in Soil from Nansha, Pearl River Delta, China
Authors: Wang Fangting , Huang Changsheng , Chen Zhihua , Bao Ke
Published: September 2019

Background: Cadmium (Cd) pollution poses a threat to human health. Examination of the spatial distribution of Cd in soils can be used to assess the risks posed to humans and the environment. Objective: This study determined the enrichment rules and factors influencing Cd pollution in Nansha, and evaluated the pollution characteristics and bioavailability of Cd in quaternary sediments through 7 deep soil profiles (0–200 cm), 4 boreholes, and 348 topsoil (0–20 cm) samples. Methods: The geo-accumulation index (Igeo) and the potential ecological risk index (Er) were used to assess ecological risk, and bioavailability was determined using multivariate, spatial distribution, and correlation matrix analyses. Results: From the Er, 52% of Nansha was classed as being at very high risk of Cd pollution; a further 36% was classed as dangerous. Cadmium was more abundant in clay soils than in sandy soils. Bioavailable Cd in quaternary sediments was significantly affected by the total Cd, and labile Cd accounted for more than half of the total Cd. Changes in pH mainly affected bioavailable Cd rather than total Cd, affecting the overall bioavailability of Cd. Conclusions: Nansha soils are commonly and seriously contaminated with Cd. An appropriate remediation treatment approach should be used to reduce Cd bioavailability. Furthermore, planting structures in farmland should be adjusted to avoid the impact of heavy metals on human health.
Non-Surgical Treatment of Periodontal Disease in a Pregnant Caucasian Women Population: Adverse Pregnancy Outcomes of a Randomized Clinical Trial
Authors: Caneiro-Queija Leticia , López-Carral Jose , Martin-Lancharro Pablo , Limeres-Posse Jacobo , Diz-Dios Pedro , Blanco-Carrion Juan
Published: September 2019

Aim: To analyze if non-surgical treatment of periodontitis in a pregnant Caucasian women population can reduce adverse pregnancy outcomes. Methods and results: A parallel randomized clinical trial was designed and approved by the Ethical Committee of Sanitary Area Santiago-Lugo, Spain (registration number: 2016/451). Forty patients with periodontitis stage II grade B were randomly allocated to receive either comprehensive non-surgical periodontal therapy (test group; n = 20) or professional tooth cleaning (control group; n = 20) before 24 gestational weeks. Randomization was computer-generated by the statistic program Epidat v.4.1 and allocation was performed using sealed opaque envelopes. Clinical measurements and peripheral blood samples for biochemical variables were collected at baseline, in the middle of second trimester before non-surgical treatment, and in the third trimester. Microbiological samples were collected in the second and third trimester. A statistically significant reduction was verified in all clinical and microbiological parameters after periodontal treatment in the test group. No significant differences were observed for the rest of the variables, including preterm birth and/or low birth weight. No adverse events related to periodontal treatment were reported. Conclusions: Non-surgical periodontal treatment in Caucasian patients with periodontitis stage II grade B did not significantly reduce the risk of adverse pregnancy outcomes.
Coordination of miR-192 and miR-22 in p53-Mediated Cell Fate Decision
Authors: Sun Cheng-Yuan , Zhang Xiao-Peng , Wang Wei
Published: September 2019

p53-targeted microRNAs (miRNAs) markedly affect cellular response to DNA damage. These miRNAs may contribute to either cell cycle arrest or apoptosis induction. However, how these miRNAs coordinate to modulate the decision between cell survival and death remains less understood. Here, we developed an integrated model of p53 signaling network to investigate how p53-targeted miR-192 and miR-22 modulate cellular outcome in response to DNA damage. By numerical simulations, we found that p53 is activated progressively depending on the extent of DNA damage. Upon moderate damage, p53 rises to medium levels and induces miR-192 to promote its own activation, facilitating p21 induction and cell cycle arrest. Upon severe damage, p53 reaches high levels and is fully activated due to phosphatase and tensin homolog (PTEN) induction. As a result, it transactivates miR-22 to repress p21 expression and activate E2F1, resulting in apoptosis. Therefore, miR-192 promotes primary activation of p53, while miR-22 promotes apoptosis by downregulating p21. This work may advance the understanding of the mechanism for cell fate decision between life and death by p53-inducible miRNAs.
Enhancing Breast Cancer Treatment Using a Combination of Cannabidiol and Gold Nanoparticles for Photodynamic Therapy
Authors: R. Mokoena Dimakatso , P. George Blassan , Abrahamse Heidi
Published: September 2019

Indisputably, cancer is a global crisis that requires immediate intervention. Despite the use of conventional treatments over the past decades, it is acceptable to admit that these are expensive, invasive, associated with many side effects and, therefore, a reduced quality of life. One of the most possible solutions to this could be the use of gold nanoparticle (AuNP) conjugated photodynamic therapy (PDT) in combination with cannabidiol (CBD), a Cannabis derivative from the Cannabis sativa. Since the use of Cannabis has always been associated with recreation and psychoactive qualities, the positive effects of Cannabis or its derivatives on cancer treatment have been misunderstood and hence misinterpreted. On the other hand, AuNP-PDT is the most favoured form of treatment for cancer, due to its augmented specificity and minimal risk of side effects compared to conventional treatments. However, its use requires the consideration of several physical, biologic, pharmacologic and immunological factors, which may hinder its effectiveness if not taken into consideration. In this review, the role of gold nanoparticle mediated PDT combined with CBD treatment on breast cancer cells will be deliberated.
Complete Sequence, Multichromosomal Architecture and Transcriptome Analysis of the Solanum tuberosum Mitochondrial Genome
Authors: Varré Jean-Stéphane , D’Agostino Nunzio , Touzet Pascal , Gallina Sophie , Tamburino Rachele , Cantarella Concita , Ubrig Elodie , Cardi Teodoro , Drouard Laurence , Gualberto José Manuel , Scotti Nunzia
Published: September 2019

Mitochondrial genomes (mitogenomes) in higher plants can induce cytoplasmic male sterility and be somehow involved in nuclear-cytoplasmic interactions affecting plant growth and agronomic performance. They are larger and more complex than in other eukaryotes, due to their recombinogenic nature. For most plants, the mitochondrial DNA (mtDNA) can be represented as a single circular chromosome, the so-called master molecule, which includes repeated sequences that recombine frequently, generating sub-genomic molecules in various proportions. Based on the relevance of the potato crop worldwide, herewith we report the complete mtDNA sequence of two S. tuberosum cultivars, namely Cicero and Désirée, and a comprehensive study of its expression, based on high-coverage RNA sequencing data. We found that the potato mitogenome has a multi-partite architecture, divided in at least three independent molecules that according to our data should behave as autonomous chromosomes. Inter-cultivar variability was null, while comparative analyses with other species of the Solanaceae family allowed the investigation of the evolutionary history of their mitogenomes. The RNA-seq data revealed peculiarities in transcriptional and post-transcriptional processing of mRNAs. These included co-transcription of genes with open reading frames that are probably expressed, methylation of an rRNA at a position that should impact translation efficiency and extensive RNA editing, with a high proportion of partial editing implying frequent mis-targeting by the editing machinery.
Expression Profile of Cell Cycle-Related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity
Authors: Ikeda Hiroko , Muratani Masafumi , Hidema Jun , Hada Megumi , Fujiwara Keigi , Souda Hikaru , Yoshida Yukari , Takahashi Akihisa
Published: September 2019

Multiple unique environmental factors such as space radiation and microgravity (μG) pose a serious threat to human gene stability during space travel. Recently, we reported that simultaneous exposure of human fibroblasts to simulated μG and radiation results in more chromosomal aberrations than in cells exposed to radiation alone. However, the mechanisms behind this remain unknown. The purpose of this study was thus to obtain comprehensive data on gene expression using a three-dimensional clinostat synchronized to a carbon (C)-ion or X-ray irradiation system. Human fibroblasts (1BR-hTERT) were maintained under standing or rotating conditions for 3 or 24 h after synchronized C-ion or X-ray irradiation at 1 Gy as part of a total culture time of 2 days. Among 57,773 genes analyzed with RNA sequencing, we focused particularly on the expression of 82 cell cycle-related genes after exposure to the radiation and simulated μG. The expression of cell cycle-suppressing genes (ABL1 and CDKN1A) decreased and that of cell cycle-promoting genes (CCNB1, CCND1, KPNA2, MCM4, MKI67, and STMN1) increased after C-ion irradiation under μG. The cell may pass through the G1/S and G2 checkpoints with DNA damage due to the combined effects of C-ions and μG, suggesting that increased genomic instability might occur in space.
Rational Design and Fabrication of ZnONPs Functionalized Sericin/PVA Antimicrobial Sponge
Authors: Ai Lisha , He Huawei , Wang Peng , Cai Rui , Tao Gang , Yang Meirong , Liu Liying , Zuo Hua , Zhao Ping , Wang Yejing
Published: September 2019

The interests of developing antimicrobial biomaterials based on silk sericin from Bombyx mori cocoon, have been shooting up in the last decades. Sericin is a valuable natural protein owing to its hydrophilicity, biodegradability, and biocompatibility. Here, we fabricated a sponge with antibacterial capacities for potential wound dressing application. By co-blending of sericin, polyvinyl alcohol (PVA) and zinc oxide nanoparticles (ZnONPs), the ZnONPs-sericin/PVA composite sponge (ZnONPs-SP) was successfully prepared after freeze-drying. Scanning electron microscopy showed the porous structure of ZnONPs-SP. Energy dispersive spectroscopy indicated the existence of Zn in the sponge. X-ray diffractometry revealed the hexagonal wurtzite structure of ZnONPs. Fourier transform infrared spectroscopy showed the biologic coupling of ZnONPs and sericin resulted in a decrease of α-helix and random coil contents, and an increase of β-sheet structure in the sponge. The swelling experiment suggested ZnONPs-SP has high porosity, good hydrophilicity, and water absorption capability. The plate bacterial colony counting coupled with growth curve assays demonstrated that the composite sponge has an efficiently bacteriostatic effect against Staphylococcus aureus and Escherichia coli, respectively. Furthermore, the cell compatibility analysis suggested the composite sponge has excellent cytocompatibility on NIH3T3 cells. In all, ZnONPs-SP composite sponge has significant potentials in biomaterials such as wound dressing and tissue engineering.
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment
Authors: Di Meo Sergio , Napolitano Gaetana , Venditti Paola
Published: September 2019

From their discovery in biological systems, reactive oxygen species (ROS) have been considered key players in tissue injury for their capacity to oxidize biological macromolecules [...]
Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial–Mesenchymal Transition
Authors: Kletukhina Sevindzh , Neustroeva Olga , James Victoria , Rizvanov Albert , Gomzikova Marina
Published: September 2019

Epithelial–mesenchymal transition (EMT) is a process that takes place during embryonic development, wound healing, and under some pathological processes, including fibrosis and tumor progression. The molecular changes occurring within epithelial cells during transformation to a mesenchymal phenotype have been well studied. However, to date, the mechanism of EMT induction remains to be fully elucidated. Recent findings in the field of intercellular communication have shed new light on this process and indicate the need for further studies into this important mechanism. New evidence supports the hypothesis that intercellular communication between mesenchymal stroma/stem cells (MSCs) and resident epithelial cells plays an important role in EMT induction. Besides direct interactions between cells, indirect paracrine interactions by soluble factors and extracellular vesicles also occur. Extracellular vesicles (EVs) are important mediators of intercellular communication, through the transfer of biologically active molecules, genetic material (mRNA, microRNA, siRNA, DNA), and EMT inducers to the target cells, which are capable of reprogramming recipient cells. In this review, we discuss the role of intercellular communication by EVs to induce EMT and the acquisition of stemness properties by normal and tumor epithelial cells.
Semiochemical and Communication Ecology of the Emerald Ash Borer, Agrilus planipennis (Coleoptera: Buprestidae)
Authors: Silk Peter , Mayo Peter , Ryall Krista , Roscoe Lucas
Published: September 2019

Knowledge of buprestid chemical ecology is sparse but the appearance of the invasive pest Agrilus planipennis Fairmaire in North America has provided the impetus to study in detail the semiochemistry and ecology of this important buprestid. The macrocyclic lactone (3Z)-12-dodecenolide [(3Z)-lactone] is identified as a key antennally-active compound that is produced by females and attracts males. Though a weak trap attractant alone, when combined with the host kairomone (3Z)-hexenol and the important visual cue of a green canopy trap, significant increases in male trap capture occur, thus defining (3Z)-lactone as both a sex pheromone of A. planipennis as well as the first and only known buprestid pheromone. The non-natural stereoisomer (3E)-12-dodecenolide and the saturated analog, 12-dodecanolide also exhibit mimetic activities towards male A. planipennis, suggesting a notable plasticity in this pheromonal structural motif. Efficient synthetic routes to these compounds have been developed. A series of fluoro-12-dodecanolides has also been synthesized containing CF2 groups as a strategy to bias the conformational space accessed by these macrolides and to assess if the analogs may act as mimetics for 12-dodecanolide pheromones associated in A. planipennis. These compounds also afford a unique opportunity to study the binding affinities of lactone surrogates with A. planipennis chemosensory proteins and olfactory receptors. Some progress has also been made in identifying the genes involved in the reception, processing and degradation of volatiles in this invasive insect. It is now evident that the behavior and ecology of A. planipennis involves a complex pattern of sensory modalities, including visual, tactile, olfactory and potentially acoustic components. Earlier reviews focused on studies of attractive host volatiles in development of a trapping system for early detection and visual and contact phenomena in A. planipennis mate finding. This review will update the semiochemistry and chemical ecology of A. planipennis and discuss studies on chemistry and behavior that have identified female-produced pheromone components and host kairomones.
A New Class of β–Pyrrolidino-1,2,3-Triazole Derivatives as β-Adrenergic Receptor Inhibitors: Synthesis, Pharmacological, and Docking Studies
Authors: Easwaramoorthi Kaliyappan , A. Rajendran Jeya , Chennakesava Rao Kella , Balachandran Chandrasekar , Arun Yuvaraj , Mahalingam Sakkarapalayam M. , Arumugam Natarajan , I. Almansour Abdulrahman , Suresh Kumar Raju , Al-thamili Dhaifallah M. , Aoki Shin
Published: September 2019

New 1,4-disubstituted β-pyrrolidino-1,2,3-triazoles were synthesized using a reusable copper-iodide-doped neutral alumina catalyst. Synthesis of diversely substituted triazoles and recyclability of CuI catalyst explains the broad scope of this protocol. The synthesized compounds were screened for their antimicrobial and anticancer properties. Most of the compounds showed significant antimicrobial activities against all the tested microorganisms compared to standard drugs. Furthermore, compounds 5a, 5e, 5g, 5h, 5i, and 5j showed moderate to potent activities against A549 and HepG-2 cells. In addition, compounds 5g and 5h displayed potential cytotoxicity activity against A549 cells with IC50 values of 72 ± 3.21 and 58 ± 2.31 µM, respectively. The molecular docking study revealed that some of the synthesized compounds exhibited comparable binding as co-crystalized ligands with the DNA topoisomerase IV and anaplastic lymphoma kinase receptors.
Bilobalide Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway
Authors: Bu Su , Yuan Chun Ying , Xue Quan , Chen Ying , Cao Fuliang
Published: September 2019

Bilobalide, the only sesquiterpene compound from Ginkgo biloba leaf, exhibits various beneficial pharmaceutical activities, such as antioxidant, anti-inflammation, and protective effects for the central nervous system. Several bioactive components extracted from Ginkgo biloba extract reportedly have the potential to attenuate lipid metabolism. However, the effect of bilobalide on lipid metabolism remains unclear. In this study, we used 3T3-L1 cells as the cell model to investigate the effect of bilobalide on adipogenesis. The results showed that bilobalide inhibited 3T3-L1 preadipocyte differentiation and intracellular lipid accumulation. Quantitative real-time PCR and western blotting results indicated that several specific adipogenic transcription factors and a few important adipogenesis-related genes were significantly down regulated on both mRNA and protein levels in bilobalide treatment groups. By contrast, the expression of some lipolytic genes, such as adipose triglyceride lipase, hormone-sensitive lipase (HSL), and carnitine palmitoyltransferase-1α, were all up-regulated by bilobalide treatment, and the phosphorylation of AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase 1, and HSL were stimulated. Furthermore, bilobalide treatment partially restored AMPK activity following its blockade by compound C (dorsomorphin). These results suggested that bilobalide inhibited adipogenesis and promoted lipolysis in 3T3-L1 cells by activating the AMPK signaling pathway.
Structural, Impedance, and EDLC Characteristics of Proton Conducting Chitosan-Based Polymer Blend Electrolytes with High Electrochemical Stability
Authors: Aziz Shujahadeen B. , Abdulwahid Rebar T. , Hamsan Muhamad H. , Brza Mohamad A. , Abdullah Ranjdar M. , Kadir Mohd F. Z. , Muzakir Saifful K.
Published: September 2019

In this report, a facile solution casting technique was used to fabricate polymer blend electrolytes of chitosan (CS):poly (ethylene oxide) (PEO):NH4SCN with high electrochemical stability (2.43V). Fourier transform infrared (FTIR) spectroscopy was used to investigate the polymer electrolyte formation. For the electrochemical property analysis, cyclic voltammetry (CV), linear sweep voltammetry (LSV), and electrochemical impedance spectroscopy (EIS) techniques were carried out. Referring to the FTIR spectra, a complex formation between the added salt and CS:PEO was deduced by considering the decreasing and shifting of FTIR bands intensity in terms of functional groups. The CS:PEO:NH4SCN electrolyte was found to be electrochemically stable as the applied voltage linearly swept up to 2.43V. The cyclic voltammogram has presented a wide potential window without showing any sign of redox peaks on the electrode surface. The proved mechanisms of charge storage in these fabricated systems were found to be double layer charging. The EIS analysis showed the existence of bulk resistance, wherein the semicircle diameter decreased with increasing salt concentration. The calculated maximum DC conductivity value was observed to be 2.11 × 10−4 S/cm for CS:PEO incorporated with 40 wt% of NH4SCN salt. The charged species in CS:PEO:NH4SCN electrolytes were considered to be predominantly ionic in nature. This was verified from transference number analysis (TNM), in which ion and electron transference numbers were found to be tion = 0.954 and tel = 0.045, respectively. The results obtained for both ion transference number and DC conductivity implied the possibility of fabricating electrolytes for electrochemical double layer capacitor (EDLC) device application. The specific capacitance of the fabricated EDLC was obtained from the area under the curve of the CV plot.
Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists
Authors: Zhou Yang , Banday Abid H. , Hruby Victor J. , Cai Minying
Published: September 2019

Cancer vaccine is a promising immunotherapeutic approach to train the immune system with vaccines to recognize and eliminate tumors. Adjuvants are compounds that are necessary in cancer vaccines to mimic an infection process and amplify immune responses. The Toll-like receptor 2 and 6 (TLR2/TLR6) agonist dipalmitoyl-S-glyceryl cysteine (Pam2Cys) was demonstrated as an ideal candidate for synthetic vaccine adjuvants. However, the synthesis of Pam2Cys requires expensive N-protected cysteine as a key reactant, which greatly limits its application as a synthetic vaccine adjuvant in large-scaled studies. Here, we report the development of N-acetylated Pam2Cys analogs as TLR2/TLR6 agonists. Instead of N-protected cysteine, the synthesis utilizes N-acetylcysteine to bring down the synthetic costs. The N-acetylated Pam2Cys analogs were demonstrated to activate TLR2/TLR6 in vitro. Moreover, molecular docking studies were performed to provide insights into the molecular mechanism of how N-acetylated Pam2Cys analogs bind to TLR2/TLR6. Together, these results suggest N-acetylated Pam2Cys analogs as inexpensive and promising synthetic vaccine adjuvants to accelerate the development of cancer vaccines in the future.
The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns
Authors: Lewandowska Małgorzata , Sajdak Stefan , Lubiński Jan
Published: September 2019

It has not yet been established, whether or not the maternal serum selenium (Se) in early pregnancy may be a risk marker of small-for-gestational age (SGA) birth weight. Selenium is important for human health and is involved in oxidative balance, a key element in the development of the placenta and fetus. This innovative study was nested in a prospective cohort of 750 women recruited in the 10–14th week of a single pregnancy, all of whom were healthy during recruitment. We examined mothers delivering SGA infants (with birth weight <10th percentile) (n = 48) and matched mothers delivering appropriate-for-gestational age (AGA) infants (between 10–90th percentile) (n = 192). We measured the maternal microelement concentrations in the serum from the 10–14th gestational week, using the inductively coupled plasma mass spectrometry (ICP-MS). The odds ratios of SGA (and 95% confidence intervals) were assessed in logistic regression. The mean maternal Se concentrations were lower in mothers in the SGA group compared to the AGA group (59.60 vs. 62.54 µg/L; p = 0.020). Women in the lowest Q1 quartile of Se (≤56.60 µg/L) have about three times higher risk of SGA compared to women in the higher quartiles (Q2 or Q4); the odds ratio of SGA was OR = 3.02 (p = 0.019) for Q1 vs. Q2 quartile. The risk profile graph confirms the results. We found that excessive pre-pregnancy BMI (body mass index) affected the estimated SGA odds ratios. Early pregnancy maternal serum selenium status can be a risk marker of SGA newborns and more research is needed in larger groups.
Preconception Folic Acid Supplement Use in Immigrant Women (1999–2016)
Authors: Nilsen Roy M. , Daltveit Anne K. , Iversen Marjolein M. , Sandberg Marit G. , Schytt Erica , Small Rhonda , Strandberg Ragnhild B. , Vik Eline S. , Aasheim Vigdis
Published: September 2019

This study examines how preconception folic acid supplement use varied in immigrant women compared with non-immigrant women. We analyzed national population-based data from Norway from 1999–2016, including 1,055,886 pregnancies, of which 202,234 and 7,965 were to 1st and 2nd generation immigrant women, respectively. Folic acid supplement use was examined in relation to generational immigrant category, maternal country of birth, and length of residence. Folic acid supplement use was lower overall in 1st and 2nd generation immigrant women (21% and 26%, respectively) compared with Norwegian-born women (29%). The lowest use among 1st generation immigrant women was seen in those from Eritrea, Ethiopia, Morocco, and Somalia (around 10%). The highest use was seen in immigrant women from the United States, the Netherlands, Denmark, and Iceland (>30%). Folic acid supplement use increased with increasing length of residence in immigrant women from most countries, but the overall prevalence was lower compared with Norwegian-born women even after 20 years of residence (adjusted odds ratio: 0.63; 95% confidence interval: 0.60–0.67). This study suggests that immigrant women from a number of countries are less likely to use preconception folic acid supplements than non-immigrant women, even many years after settlement.
Re-Enchanting Political Theology
Authors: Kidwell Jeremy H.
Published: September 2019

For this Special Issue which confronts the ways in which the question of pluralism represents both haunting and promise within modern political theology, I explore the presence of pluralism in the context of the environmental crisis and religious responses to issues such as climate change. Following Jason Ā. Josephson-Storm, I suggest that models of disenchantment are misleading—to quote Latour, “we have never been modern.” In engagement with a range of neo-vitalist scholars of enchantment including Rosi Braidotti, Karen Barad, Isabelle Stengers, Jane Bennett and William Connolly, I explore the possibility of a kind of critical-theory cosmopolitics around the concept of “enchantment” as a possible site for multi-religious political theology collaborations and argue that this is a promising post-secular frame for the establishment of cosmopolitical collaborations across quite profound kinds of difference.
Jingjiao under the Lenses of Chinese Political Theology
Authors: Ken-pa Chin
Published: September 2019

Conflict between religion and state politics is a persistent phenomenon in human history. Hence it is not surprising that the propagation of Christianity often faces the challenge of “political theology”. When the Church of the East monk Aluoben reached China in 635 during the reign of Emperor Tang Taizong, he received the favorable invitation of the emperor to translate Christian sacred texts for the collections of Tang Imperial Library. This marks the beginning of Jingjiao (景教) mission in China. In historiographical sense, China has always been a political domineering society where the role of religion is subservient and secondary. A school of scholarship in Jingjiao studies holds that the fall of Jingjiao in China is the obvious result of its over-involvement in local politics. The flaw of such an assumption is the overlooking of the fact that in the Tang context, it is impossible for any religious establishments to avoid getting in touch with the Tang government. In the light of this notion, this article attempts to approach this issue from the perspective of “political theology” and argues that instead of over-involvement, it is rather the clashing of “ideologies” between the Jingjiao establishment and the ever-changing Tang court’s policies towards foreigners and religious bodies that caused the downfall of Jingjiao Christianity in China. This article will posit its argument based on the analysis of the Chinese Jingjiao canonical texts, especially the Xian Stele, and takes this as a point of departure to observe the political dynamics between Jingjiao and Tang court. The finding of this paper does show that the intellectual history of Chinese Christianity is in a sense a comprehensive history of “political theology”.
New Roles for Indigenous Women in an Indian Eco-Religious Movement
Authors: Borde Radhika
Published: September 2019

This article aims to study how a movement aimed at the assertion of indigenous religiosity in India has resulted in the empowerment of the women who participate in it. As part of the movement, devotees of the indigenous Earth Goddess, who are mostly indigenous women, experience possession trances in sacred natural sites which they have started visiting regularly. The movement aims to assert indigenous religiosity in India and to emphasize how it is different from Hinduism—as a result the ecological articulations of indigenous religiosity have intensified. The movement has a strong political character and it explicitly demands that indigenous Indian religiosity should be officially recognized by the inclusion of a new category for it in the Indian census. By way of their participation in this movement, indigenous Indian women are becoming figures of religious authority, overturning cultural taboos pertaining to their societal and religious roles, and are also becoming empowered to initiate ecological conservation and restoration efforts.
Reconstructing Aircraft Trajectories from Multi-Return Airborne Laser-Scanning Data
Authors: Gatziolis Demetrios , McGaughey Robert J.
Published: September 2019

Data describing aircraft position and attitude are essential to computing return positions from ranging data collected during airborne laser scanning (ALS) campaigns. However, these data are often excluded from the products delivered to the client and their recovery after the contract is complete can require negotiations with the data provider, may involve additional costs, or even be infeasible. This paper presents a rigorous, fully automated, novel method for recovering aircraft positions using only the point cloud. The study used ALS data from five acquisitions in the US Pacific Northwest region states of Oregon and Washington and validated derived aircraft positions using the smoothed best estimate of trajectory (SBET) provided for the acquisitions. The computational requirements of the method are reduced and precision is improved by relying on subsets of multiple-return pulses, common in forested areas, with widely separated first and last returns positioned at opposite sides of the aircraft to calculate their intersection, or closest point of approach. To provide a continuous trajectory, a cubic spline is fit to the intersection points. While it varies by acquisition and parameter settings, the error in the computed aircraft position seldom exceeded a few meters. This level of error is acceptable for most applications. To facilitate use and encourage modifications to the algorithm, the authors provide a code that can be applied to data from most ALS acquisitions.
Considerations about the Signal Level Measurement in Wireless Sensor Networks for Node Position Estimation
Authors: Dolha Stelian , Negirla Paul , Alexa Florin , Silea Ioan
Published: September 2019

Wireless Sensor Networks (WSN) are widely used in different monitoring systems. Given the distributed nature of WSN, a constantly increasing number of research studies are concentrated on some important aspects: maximizing network autonomy, node localization, and data access security. The node localization and distance estimation algorithms have, as their starting points, different information provided by the nodes. The level of signal strength is often such a starting point. A system for Received Signal Strength Indicator (RSSI) acquisition has been designed, implemented, and tested. In this paper, experiments in different operating environments have been conducted to show the variation of Received Signal Strength Indicator (RSSI) metric related to distance and geometrical orientation of the nodes and environment, both indoor and outdoor. Energy aware data transmission algorithms adjust the power consumed by the nodes according to the relative distance between the nodes. Experiments have been conducted to measure the current consumed by the node depending on the adjusted transmission power. In order to use the RSSI values as input for distance or location detection algorithms, the RSSI values can’t be used without intermediate processing steps to mitigate with the non-linearity of the measured values. The results of the measurements confirmed that the RSSI level varies with distance, geometrical orientation of the sensors, and environment characteristics.