bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of Scabies in A Persian Mixed Cat at UPTD. Puskeswan, Bukittinggi City
Authors: Septiana Dwi Serly , Amir Yurni Sari , Sujatmiko Sujatmiko , Siregar Ramond , Zelpina Engki , Silfia Effi , Sari Radhiati Kemala
Published: November 2022

Background: Sarcoptes scabiei is one of the ectoparasites that usually attack cats. This parasitic disease can be transmitted through direct contact with other animals affected by scabies or by the presence of a source of scabies in the area where the cat lives. Purposes: This study aimed to determine the handling of cases of scabies in a Persian mixed-breed cat (Pobo) at UPTD. Puskeswan, Bukittinggi City. Methods: Handling began with anamnesis and continued by examining the patient's physical condition and observing the body parts infected with scabies. A deep skin scraping was performed on the facial area, followed by microscopic and hematological examination. Results: Examination showed Sarcoptes scabiei infestation in the scraped skin layer and the cat was anemic. The cat patient with scabiosis received Ivomec® as an antiparasitic. Symptomatic treatment was also carried out by giving Vet-oxy SB® and Vetadryl® injections as antibiotics because a secondary infection was suspected. Conclusions: The therapy administered showed positive progressive results in the patient.
Pink Eye Cases in Sheep at UD. Peternakan Boerstud Kambing Boerja, Malang
Authors: Dyah Laksito Rukmi  , Maulida Riski Bagda , Nurkholis Nurkholis , Kustiawan Erfan , Siswantoro Dharwin
Published: November 2022

Background: Pink Eye was an eye disease that can be transmitted to livestock either by direct contact with infected livestock as well as through vectors of flies, dust, and water. Pink Eye can cause chronic cases and lasts all year round. This causes losses to farmers starting from decreased appetite which results in weight loss and even to the death of livestock. Purpose: The purpose of this case study was to provide information on efforts to prevent and treat Pink Eye disease in UD. Peternakan Boerstud Kambing Burja, Malang. Method: The methods used include collecting primary data in the field while secondary data is obtained from record book the UD. Peternakan Boerstud Kambing Burja, Malang. The prevalence of Pink Eye events from September-December 2021 shows that as many as 55 out of 110 sheep or 50% of the total sheep population are infected with Pink Eye disease. Results: The healing process of Pink Eye is carried out by carrying out treatment consistently with the administration of oxytetracycline eye ointment which is topically applied in the morning and evening. The period of time required for the healing process for 3 days depends on the severity of the infection. Conclusions: The recovery of the eyes of sheep infected with Pink Eye by 100%.
EFFORTS IN CONTROLLING COAL DUST HAZARDS IN THE STOCKPILE AREA OF A STEAM POWER PLANT (PLTU)
Authors: Alifiah Rizky Rosydah  , Y. Denny Ardyanto Wahyudiono  , Ahmad Imaduddin  , Dani Nasirul Haqi  , Meirina Ernawati
Published: November 2022

Background: The movement of coal or other activities in the stockpile area of a steam power plant can create a coal dust hazard or commonly referred to as respirable dust. The smaller the particle size, the more harmful effects it can have on human health, such as bronchitis, decreased lung function, Chronic Obstructive Pulmonary Disease (COPD), Coal Worker's Pneumoconiosis (CWP), and other respiratory diseases. Purpose: To study the chemical hazards of the working environment of coal dust and the control efforts conducted in the stockpile area of a steam power plant company. Method: This research was descriptive observational with a cross-sectional study. The data were comprised of primary data collected from interviews and observations, and secondary data such as environmental measurement report and documentations owned by company. Result: The results of the measurement of coal dust hazard in the stockpile are were 0.007 mg/m3 and 0.063 mg/m3 for personal dust measurements. Some of the coal-dust-hazard control efforts performed by PT. POMI included the installation of a spray gun, a dust suppression system, reforestation, and ventilation setting. Further, OHS induction was conducted, together with safety talk, working hour regulations, toolbox meeting, training on the use of PPE, Medical Check Up (MCU), person authorization, preventive maintenance, and the use of PPE by workers. Conclusion: The measurement of the coal dust hazard in the stockpile area is below the threshold value which is 3 mg/m3 for respirable particles and 10 mg/m3 for inhalable particles. PT. POMI has done several preventive and control efforts towards coal dust hazard, and there were no health problems found in workers.
Smart Attendance for Faculty Monitoring System Using the Bluetooth Low Energy: Design and Implementation
Authors: Jantan Siti Robaya , Rasli Amran , Mohd Zainudin Anis Juanita , Mustafa@Dain Noor Wahidah , Khairuzzaman Mohamed Ghazali
Published: November 2022

Student attendance serves many other important purposes aside from monitoring. In certain universities, the attendance of students in a course is also used as one of the requirements for students to be allowed to sit for the final examination. Traditionally, among most Malaysian Institutions of Higher Learning (IHL), attendance recording is usually done using pen and paper, or uses simple web-based system that is time consuming and difficult for faculty periodic monitoring. To address the identified drawbacks, this research aims to develop a Smart Attendance for Faculty Monitoring System using the Bluetooth Low Energy (BLE) technology to assist faculty in recording, managing and monitoring students’ attendance and class schedules effectively. The system is developed for Android-based devices using an agile methodology consists of iteration and incremental approaches. Thus, to evaluate the effectiveness of the system, a survey was conducted on 140 respondents involving lecturers and students of Kolej Universiti Poly-Tech MARA (KUPTM). Respondents were selected using purposive sampling. The descriptive analysis showed that 87.9% of the respondents strongly agreed that the system is effective in assisting lecturers to record attendance, manage class schedules and student attendance as well as to assist faculty in monitoring students’ absenteeism.
Explanation of the Nano Quantum Electron Transport From Populated Occupied Higher Bound Energy States to Unoccupied Lower States
Authors: A.Ahmed Najwa Idris , Alamri Mona A. , Sonia Soltani , Saad Zoalnoon Ahmed Abeid Allah
Published: November 2022

Maxwell's electric equation and Schrödinger quantum equation are used to find useful expressions for the probability of electrons existence and the electrons transport. The first expression which uses special relatively also shows that the probability of the electrons existence is higher for lower energy states compared to higher energy states where the probability is low. This means that electrons transport takes place from higher energy states to lower states. This conforms to the laws of chemistry where the atom tends to be stable by forcing electrons to occupy lower energy states. The second expression used the momentum velocity relation instead of special relatively. This expression shows also electrons transport from higher to lower states. It also shows that the probability of the electrons existence is higher for lower electrons density regions and lower for higher electrons density regions. This means that the electrons transport is from higher density regions to lower density regions. This conforms to the diffusion law.
Reinforcement Learning-based Wi-Fi Contention Window Optimization
Authors: Cruz Sheila C. da S. , Ahmed Ouameur Messaoud , Figueiredo Felipe A. P. de
Published: November 2022

The collision avoidance mechanism adopted by the IEEE 802.11 standard is not optimal. The mechanism employs a binary exponential backoff (BEB) algorithm in the medium access control (MAC) layer. Such an algorithm increases the backoff interval whenever a collision is detected to minimize the probability of subsequent collisions. However, the expansion of the backoff interval causes degradation of the radio spectrum utilization (i.e., bandwidth wastage). That problem worsens when the network has to manage the channel access to a dense number of stations, leading to a dramatic decrease in network performance. Furthermore, a wrong backoff setting increases the probability of collisions such that the stations experience numerous collisions before achieving the optimal backoff value. Therefore, to mitigate bandwidth wastage and, consequently, maximize the network performance, this work proposes using reinforcement learning (RL) algorithms, namely Deep Q Learning (DQN) and Deep Deterministic Policy Gradient (DDPG), to tackle such an optimization problem. As for the simulations, the NS-3 network simulator is used along with a toolkit known as NS3-gym, which integrates a reinforcement-learning (RL) framework into NS-3. The results demonstrate that DQN and DDPG have much better performance than BEB for static and dynamic scenarios, regardless of the number of stations. Moreover, the performance difference is amplified as the number of stations increases, with DQN and DDPG showing a 27% increase in throughput with 50 stations compared to BEB. Furthermore, DQN and DDPG presented similar performances.
Geochemical Characterization of Nyamyumba Hot Springs, Northwest Rwanda
Authors: Hategekimana Francois , Mugerwa Theophile , Nsengiyumva Cedrick , Byiringiro Fils Vainqueur , Rwabuhungu Digne Edmond R.
Published: November 2022

Hot spring is a hot water that is naturally occurring on the surface from the underground and typically heated by subterranean volcanic activity and local underground geothermal gradient. There are four main hot springs in Rwanda such as: Kalisimbi, Bugarama, Kinigi and Nyamyumba former name Gisenyi hot springs. It is often believed that soaking in hot springs is a great way which naturally detox human skin. This research focused on the geochemical analysis of Nyamyumba hot springs located near the fresh water of Lake Kivu for the purpose of understanding its healing capacity and safety. Nyamyumba hot springs are located in the western branch of the East African Rift System and they are located near Virunga volcanic complex, explaining the rising and heating mechanism of water. The concentrations of Sulfate, Iron, Ammonia, Alkalinity, Silica, Phosphate, Salinity, Alkalinity, and Conductivity using standard procedures were measured. The results showed that hot spring water has higher concentrations of chemicals compared to Lake Kivu water and the geochemistry of these hot springs maybe associated with rock dissolution by hot water. The measured parameters were compared with World Health Organization (WHO) standards for recreational waters and it has been identified that Nyamyumba hot springs are safe to use in swimming and therapeutic activities.
Gaussian Process and Deep Learning Atmospheric Correction
Authors: Basener Bill , Basener Abigail
Published: November 2022

Atmospheric correction is the processes of converting radiance measured at a spectral 1 sensor to the reflectance of the materials in a multispectral or hyperspectral image. This is an 2 important step for detecting or identifying the materials present in the pixel spectra. We present 3 two machine learning models for atmospheric correction trained and tested on 100,000 batches of 40 4 reflectance spectra converted to radiance using MODTRAN, so the machine learning model learns 5 the radiative transfer physics from MODTRAN. We created a theoretically interpretable Bayesian 6 Gaussian process model and a deep learning autoencoder treating the atmosphere as noise. We 7 compare both methods for estimating gain in the correction model to the well-know QUAC method 8 of assuming a constant mean endmember reflectance. Prediction of reflectance using the Gaussian 9 process model outperforms the other methods in terms of both accuracy and reliability.
LightMAN: A Lightweight Microchained Fabric for Assurance and Resilience Oriented Urban Air Mobility Networks
Authors: Xu Ronghua , Wei Sixiao , Chen Yu , Chen Genshe , Pham Khanh
Published: November 2022

Rapid advancements in the fifth generation (5G) communication technology and mobile edge computing (MEC) paradigm lead to the proliferation of unmanned aerial vehicles (UAV) in urban air mobility (UAM) networks, which provide intelligent services for diversified smart city scenarios. Meanwhile, the widely deployed internet of drones (IoD) in smart cities also brings up new concerns on performance, security, and privacy. The centralized framework adopted by conventional UAM networks is not adequate to handle high mobility and dynamicity. Moreover, it is necessary to ensure device authentication, data integrity, and privacy preservation in UAM networks. Thanks to characteristics of decentralization, traceability, and unalterability, Blockchain is recognized as a promising technology to enhance security and privacy for UAM networks. In this paper, we introduce LightMAN, a lightweight microchained fabric for data assurance and resilience-oriented UAM networks. LightMAN is tailored for small-scale permissioned UAV networks, in which a microchain acts as a lightweight distributed ledger for security guarantees. Thus, participants are enabled to authenticate drones and verify the genuineness of data that is sent to/from drones without relying on a third-party agency. In addition, a hybrid on-chain and off-chain storage strategy is adopted that not only improves performance (e.g,.latency and throughput) but also ensures privacy preservation for sensitive information in UAM networks. A proof-of-concept prototype is implemented and tested on a Micro Air Vehicle Link (MAVLink) simulator. The experimental evaluation validates the feasibility and effectiveness of the proposed LightMAN solution.
The Relationship of Renal Resistive Index and Central Venous Pressure As Predictors of Acute Kidney Injury in Critically III Patients of Intensive Care Unit Adam Malik General Hospital Medan
Authors: Wira Muhammad Apriandi , Hanafie Achsanuddin , Lubis Asmin , Lubis Bastian
Published: November 2022

Background: Changes in the doppler-based renal resistive index (RRI) occur prior to the changes of glomerular filtration rate (GFR) during the development of acute kidney injury (AKI) and during the healing process from AKI. Central venous pressure (CVP) is not only a marker for resuscitation, but also can determine the microcirculatory perfusion pressure as outflow obstruction.

Objective: This study aims to determine the relationship between RRI and CVP as a predictor of AKI in critically ill patients admitted to the intensive care unit (ICU) of Adam Malik General Hospital.

Methods: This was an observational study with prospective cohort design and diagnostic test method. This research was conducted at the Adam Malik General Hospital Medan from June to July 2020. Forty patients aging 18-65 years old who met the diagnostic criteria of sepsis and septic shock were examined for RI and CVP when admitted to the ICU.

Results: RI had better sensitivity and specificity than CVP in predicting the incidence of AKI (sensitivity 68% vs 59%, specificity 77% vs 55.5%, Receiver operating characteristics (ROC) 0.870 vs 0.321 (95% confidence interval)).

Conclusion: Based on the results of this study, the renal resistive index has better sensitivity and specificity than central venous pressure in predicting the incidence of AKI in critical patients in the ICU.
Kilisli Hocazâde Abdullah Enverî’ye Göre Mantığın Önemi ve Mantığın Eğitim, Kelam ve İnanç ile İlişkisi
Authors: GÜNDÜZ Ramazan
Published: November 2022

Mantık, İslâm düşüncesinde İmam Gazâlî’nin teşebbüsleriyle İslami ilimlerin metodolojisi haline geldikten sonra medreselerin temel müfredatına girmiş bir ilim dalıdır. Mantık bu konumunu Gazâlî’den sonra günümüze kadar devam ettirmiş, bu ilme telif ettikleri eserlerle yeni yaklaşımlar kazandıran birçok İslâm düşünürü yetişmiştir. Osmanlı devletinin kültürel coğrafyasında mantık ilmine gerek merkezden (İstanbul), gerekse çevredeki ilim merkezlerinden ciddi katkılar yapılmıştır. Mantık ilmine eğitim ve telifâtlar ile katkı veren dönemin ilim çevrelerinden biri de Kilis’teki âlimler olmuştur. 18. ve 20. yüzyıl arasında Kilis’teki Osmanlı medreselerinde ulusal ve uluslararası şöhrete ulaşmış bir mantık geleneği oluşmuştur. Mantık ilmini Kilis’te ilk başlatan ve yaygınlaştıran Mantıkî Hacı Ömer Efendi, Hocazâde Abdurrahman Efendi ve Hocazade Abdullah Enverî gibi Kilisli Mantık âlimleri, mantık üzerine özgün ve haşiye niteliğinde eserler yazmışlardır. İlimlerin efendisi olarak gördüğü mantık sahasında birçok telif ve haşiye türü eser kaleme alan Abdullah Enverî (öl.1304/1887), özellikle mantığın kıyas formlarında Türkçe örnekler vererek mantık eğitim dilinin millileşmesine katkılar sunmuş; mantık eğitiminin konuşulan dilde yapılmasının gereğini ortaya koymuştur. Abdullah Enverî, mantık-eğitim, mantık-din, mantık-diğer ilimler ilişkisi üzerinde serdettiği fikirleriyle mantığın bireysel ve toplumsal hayatın bütün veçhelerini ilgilendiren bir ilim olduğunu ortaya koymaya çalışmıştır. Ona göre mantıksız bir eğitim verimli olmayacağı gibi mantıki temellerle ispatlanamamış bir inanç da daima zayıf kalarak taklitten kurtulamayacaktır.Bu makale Abdullah Enverî’nin mantık ilmine verdiği önem ve mantığın eğitim ve inançla ilişkilendirmesinde ortaya koyduğu tezleri analiz ederek Enverî’nin mantık ilmini bir sanat olarak görmesinin yansımalarını incelemeye çalışmaktadır.
Expression of Klotho in follicles of patients with polycystic ovary syndrome and its clinical significance
Authors: Song Yali , Ye Wenting , Xie Tingting , Yang Yi , Luo Xiaoqing , Zhou Lili
Published: November 2022

Background
PCOS is a common endocrine and metabolic disease related to infertility in women. Klotho, an anti-aging factor, was reported up-regulated in PCOS and related to excessive androgens. However, the role of Klotho in poor oocytes quality of PCOS who underwent IVF-ET has not been clarified.
Methods
72 PCOS and 70 healthy participants who underwent IVF-ET were enrolled and the follicular fluid was collected. Granulosa cells were collected from 15 patients. The level of Klotho in follicular fluid was tested by ELISA. The mRNA level of relative genes in granulosa cell were detected by qRT-PCR.
Results
the mRNA level of Klotho, Caspase-3, Caspase-9, IL-6 and TNF in PCOS group was significantly higher, especially in the group of PCOS with hyperandrogenism, while PCNA and GDF9 was down-regulated. Correlation analysis shown that level of Klotho in follicular fluid of PCOS group was negatively correlated with the number of mature oocytes. Similarly, we divided the PCOS group into two groups according to the median of Klotho level and found that the number of mature oocytes is significantly lower in the group of high level of Klotho. In addition, the Klotho level in follicular fluid was also positively correlated with serum testosterone, LH, LH/FSH, menstrual cycle and number of total antral follicles in the group of PCOS.
Conclusion
These data suggested that Klotho may act as a new biomarker evaluating the quality of oocytes in patients with PCOS, indicating the severity of PCOS and the outcome of IVF in PCOS patients.
Retinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome
Authors: Turco Elisa Maria , Giovenale Angela Maria Giada , Sireno Laura , Mazzoni Martina , Cammareri Alessandra , Marchioretti Caterina , Goracci Laura , Veroli Alessandra Di , D'Andrea Daniel , Marchesan Elena , Torres Barbara , Bernardini Laura , Magnifico Mariachiara , Paone Alessio , Rinaldo Serena , Monica Matteo Della , D'Arrigo Stefano , Postorivo Diana , Nardone Anna Maria , Zampino Giuseppe , Onesimo Roberta , Leoni Chiara , Caicci Federico , Raimondo Domenico , Binda Elena , Trobiani Laura , De Jaco Antonella , Tata Ada Maria , Ferrari Daniela , Cutruzzolà Francesca , Mazzoccoli Gianluigi , Ziviani Elena , Pennuto Maria , Vescovi Angelo , Rosati Jessica
Published: November 2022

Smith-Magenis syndrome (SMS) is a neurodevelopmental disorder characterized by cognitive and behavioral symptoms, obesity, and sleep disturbance. There is no therapy to alleviate its symptoms or delay disease onset. SMS occurs due to haploinsufficiency of the retinoic acid-induced-1 (RAI1) gene caused by either chromosomal deletion (SMS-del) or RAI1 missense/nonsense mutation. The molecular mechanisms underlying SMS are not known. Here, we generated and characterized primary cells derived from four SMS patients, two carrying SMS-del and two carrying RAI1 point mutations, and four control subjects to investigate the pathogenetic processes underlying SMS. By combining transcriptomic and lipidomic analyses, we show altered expression of lipid and lysosomal genes, deregulation of lipid metabolism, accumulation of lipid droplets, and a block of autophagic flux. SMS cells show increased cell death associated with mitochondrial pathology and reactive oxygen species production. Treatment with N-acetylcysteine reduces cell death and lipid accumulation, suggesting a causative link between metabolic dyshomeostasis and cell viability. Our results highlight the pathological processes in human SMS cells involving lipid metabolism, autophagy defects and mitochondrial dysfunction and suggest new potential therapeutic targets for patient treatment.
Correction of severe lower limb deformity with digital hexapod external fixator based on CT data
Authors: Lu Yufeng , Li Jinfeng , Qiao Feng , Xu Zhaochen , Zhang Baogang , Jia Bin , He Jinlong , Qi Liang , Wang Min , Fei Chen , Cao Xiaoming
Published: November 2022

Purpose: The current study aimed to investigate the therapeutic effect of our self-developed digital six-axis external fixator technique for correction of severe deformities of the lower extremities.
Patients and Methods: From January 2017 to December 2020, our institution used self-developed digital hexapod external fixator technology（QSF）based on CT data to slowly correct 28 severe tibial deformities, and 15 femurs underwent osteotomy and internal fixation. The mean age was 32.6±14.3 years, and the mean follow-up was 23.3±16.1 months. MAD, mFTA, MPTA, LLD, mLDFA at preoperative and final follow-up, and LEFS, KSS and functional score at preoperative and final follow-up were compared.
Results: The QSF adjustment time was 21.4±10.8 days, and the healing time of the tibial osteotomy site was 17.6±7.0 weeks. Preoperative MAD, mFTA, MPTA were 54.1±26.2 mm, 167.7±15.7°, 75.2±12.0°, respectively. At last follow-up, MAD was 8.2±9.9 mm, mFTA was 177.6±3.4°, and MPTA was 87.6±2.4°. Significant improvement was achieved after operation. Preoperative LLD, mLDFA were 13.8±18mm, 83.7±10.8°, at last follow-up were 7.6±7.6mm, 87.8±2.6mm, no significant difference before and after operation. The LEFS, KSS and functional scores improved from 51.6 ± 11.2, 68.5 ± 11.7, 67.8 ± 11.2 to 72.3 ± 6.1, 92.9 ± 3.4, 94.2 ± 6.3, respectively.
Conclusions: The QSF technique can accurately correct severe multiplanar deformities of the tibia in adults. Combined with femoral osteotomy to correct femoral deformity, satisfactory lower extremity alignment can be obtained. The technology has the advantages of simple operation, reliable fixation, less trauma and less complications.
Level of Evidence：Level IV, case series.
Pedological Data for the Study of Soils Developed Over a Limestone Bed in a Humid Tropical Environment
Authors: Ofem Kokei Ikpi , John Kingsley , Ediene Victoria Francis , Kefas Patrick Katan , Ede Alungbe Moses , Ezeaku Victor Ikemefuna , Pawlett Mark
Published: November 2022

Lithological characteristics interact with other factors of soil formation to define soil genesis. This becomes more interesting as data on the mineral and elemental oxide components of soils developed from limestone are rarely available in the humid tropical environment. The present study investigated the elemental oxide content, forms of sesquioxides, and clay mineral species in some limestone soils. Soil samples were obtained from three (3) crestal soil profile pits and analyzed for elemental content by the use of X-ray Fluorescence spectrometer, and sesquioxides forms by Inductively Coupled Plasma-Mass Spectrometer. Analyses were done in triplicates. The mineralogy of the clay fraction was determined on the A, B, C horizon samples using an X-ray diffraction Technique. The occurrence of SiO2 (203-277 g/kg), Al2O3 (65-105 g/kg), and Fe2O3 (14-95 g/kg) in substantial amounts over MnO2, ZrO2, and TiO2 with negligible quantities of CaO suggested comparatively more developed soils in the Agoi Ibami and Mfamosing tropical rainforests. Crystalline form of Fe was dominant over amorphous form, with indications of the co-migration of dithionite Fe with clay to the B horizons of the soils. Quartz, kaolinite, montmorillonite, and chlorite-vermiculite-montmorillonite interlayered minerals dominated the clay mineralogy of the studied soils. Mineral transformation places the soils at the transitory stage from the intermediate to the complete stage of soil development. The expanding clay minerals are most likely to increase plant nutrient adsorption and soil fertility status to accommodate the cultivation of a wider range of crops.
Beneficial effects of tannic acid on comorbid anxiety in cecal ligation and puncture-induced sepsis in rats and potential underlying mechanisms
Authors: Ranjbaran Mina , Kianian Farzaneh , Ashabi Ghorbangol , Lorian Keivan , Azizi Fateme
Published: November 2022

Sepsis-associated encephalopathy (SAE), a neurological dysfunction caused by sepsis, is the most common complication among septic ICU patients. Given the major role of inflammation in the pathophysiology of sepsis-induced anxiety, an extreme and early manifestation of SAE, the present study examined whether tannic acid, as an anti-inflammatory agent, has anxiolytic effects in cecal ligation and puncture (CLP)-induced sepsis. Forty male Wistar rats were assigned to four groups: 1) Sham; 2) Sham + Tannic acid; 3) Sepsis and 4) Sepsis + Tannic acid. Sepsis was induced by cecal ligation and puncture model. Animals in the Sham + Tannic acid and Sepsis + Tannic acid groups received tannic acid (20 mg/kg, i.p.), 6, 12 and 18 h after the sepsis induction. Twenty four hours after the sepsis induction, systolic blood pressure and sepsis score were assessed. Anxiety-related behaviors were evaluated using elevated plus-maze and dark-light transition tests. Moreover, inflammatory markers (TNF-α and IL-6), oxidative stress parameters (MDA and SOD) and protein levels (GABAA receptors and IL-1β) were measured in the brain tissue samples. Administration of tannic acid significantly improved sepsis score and hypotension which induced by sepsis. Anxiety-related behaviors showed a significant decrease in the Sepsis + Tannic acid group compared to the Sepsis group. Tannic acid caused a significant decrease in the brain inflammatory markers and a remarkable improvement in the brain oxidative status compared to the septic rats. Tannic acid prevented animals from decreasing GABAA receptors and increasing IL-1β protein levels in the brain tissue samples compared to the Sepsis group. This study indicated that tannic acid mitigated anxiety-related behaviors through decreasing inflammation and oxidative stress and positive modifying IL-1β/GABAA receptors pathway. Therefore, tannic acid shows promise as an efficacious treatment for comorbid anxiety in septic patients.
Specific clinical characteristics are correlated with long-term SARS CoV-2 IgG titers
Authors: Schnapp Aviad , Gutbir Yuval , Ohana-Sarna Lea , Ben-Nachum Noa , Benenson Talya , Gilad Rivka , Lazaroff Heiley , Zamir Chen Stein , Shimon Reif , Wolf Dana , Kerem Eitan
Published: November 2022

Purpose
To investigate the correlation between various clinical characteristics and long-term SARS CoV-2 IgG following a COVID-19 outbreak in a school.
Methods
532 sera of polymerase chain reaction (PCR)-tested children, adolescents and adults were collected seven months following a large eruption of COVID-19 in a high school in Jerusalem. Anti-S IgG antibody titers were obtained, quantified and analyzed in relation to clinical symptoms resulting from SARS CoV-2 infection.
Results
Only 80% of PCR-positive individuals at the time of the outbreak were seropositive seven months following exposure. IgG positivity was well-correlated with PCR-positivity, as was the IgG titer (ß=0.56, p < 0.01). Other correlations established included young age (ß=-0.12, p < 0.01) and symptoms including fever (ß=0.11, p = 0.02) and weakness (ß=0.14, p = 0.01). Households of individuals with negative serologies had fewer symptomatic members than households of IgG-positive individuals (p < 0.01).
Conclusions
Clinical symptoms of fever and weakness may serve as predictive factors for long-term SARS-CoV-2 IgG following exposure to the virus.
Effectiveness of a Drug Reminder Mobile Phone Application in Adhering to Uric Acid Lowering Therapy in Patients with Gout: An Open-Label, Randomized Controlled Trial
Authors: Phutthinart Nattharadee , Thaweeratthakul Phakhamon , Chanapai Wanwisa , Katchamart Wanruchada
Published: November 2022

Background: Most patients with chronic diseases have difficulties adhering to treatment,leading to unfavorable outcomes and anincreased healthcare burden. Our objective wasto evaluate the effectiveness of a drug reminder mobile phone application (app) in the adherence of patients to uric lowering therapy (ULT) in patients with gout with poor adherence.
Methods: We conducted an open-label,randomized controlled trial in 54 gout patients who had serum uric acid (SUA) greaterthan 6 mg/dL and poor adherence to ULT. The patients were randomly assigned to the reminder app "Drug diary" (N =25) or the patient education app "Roo-Rak-Koh" (N =29). The co-primary end points were the proportion of patients with high ULT adherence, based on the Medication Taking Behavior measure for Thai Patients (MTB-T) questionnaire, the percentage of adherence to the pill count, and the proportion of patients who achieved the SUA target (< 6 mg/dL). A stable dose of ULT was required throughout the study.
Results: At 12 weeks, the proportion of patients with high ULT adherence and the percentage of pill count were significantly higher in the drug reminder app group (63% vs 37%, p = 0.047 for MTB-T and 96% vs 93%, p=0.04, for pill count), while the SUA target was achieved in 48% and 47.8% in the drug reminder app group and in the patient education app group, respectively (p = 0.89). However, SUA reduction in SUA was significantly greater in the drug reminder app group (-1.63 ± 1.18 vs -0.76 ± 1.24, p = 0.01).
Conclusion:Mobile phone health applications can improve medical adherence in patients with chronic diseases requiring long-term medical treatment. In addition to drug reminder, optimal gout education also significantly improves gout care.
Trial registration: Thai Clinical Trial Registry (TCTR), TCTR20200123002. Registered 23 January 2020,http://www.thaiclinicaltrials.org/show/TCTR20200123002
Efficient adsorptive removal of diclofenac sodium by acidified MIL101(Cr): optimizing the content of phosphotungstic acid (PTA), Flow loop thin film slurry flat plate reactor, Kinetic, thermodynamic and recycling studies
Authors: Sharifian Sina , Tabrizi Farshad Farshchi , Sardarian Ali Reza
Published: November 2022

The performance of Diclofenac sodium (DFs) adsorption by MIL101(Cr) and five different contents of PTA in PTA@MIL101(Cr) (encapsulated phosphotungstic acid (PTA) using one pot method) were investigated in a batch and a designed continuous flow loop thin film slurry flat plate reactor (TFSR). Excellent diclofenac sodium adsorption efficiency was achieved with 12 wt% PTA synthesized within the Metal Organic Framework (MOF) and using the Langmuir equation the maximum adsorption capacity of diclofenac sodium was 413.22 mg/g. The Langmuir model matched the isotherm adsorption data and the removal process was complemented with a pseudo–second–order kinetics model. According to the thermodynamic analyses, the process was found to be spontaneous and endothermic. In order to regenerate the MOF, 0.1 M HCl/EtOH (20/80 v/v) best performed as elution agent, regenerating the MOF to 88% of its originated maximum capacity after 5 times reusing. PTA (12 wt%) @MIL101 (Cr) showed to be a tremendous reusable adsorbent for removing DFs from aqueous media.
Splines finite element solver for one-dimensional time-dependent Maxwell’s equations via Fourier Transform Discretization
Authors: Addam Mohamed , Bouhamidi Abderrahman , BARKANI Imad EL
Published: November 2022

In this article, we solve the time-dependent Maxwell coupled equations in their one-dimensional
version relatively to space-variable. We effectuate a variable reduction via Fourier transform to make
the time variable as a frequency parameter easy and quickly to manage. A Galerkin variational
method based on higher-order spline interpolations is used to approximate the solution relatively to
the spacial variable. So, the state of existence of the solution, its uniqueness, and its regularity are
studied and proved, and the study is also provided by an error estimate. Also, we use the critical
Nyquist frequency to calculate numerically the solution of the Inverse Fourier Transform(IFT); and
for all numerical computations, we consider several quadrature methods. We give some experiments
to illustrate the success of such an approach. Finally, we apply the higher-order spline interpolants
to solve the first kind of Fredholm integral equation and Pocklington’s integro-differential equation to
treat the signal reconstruction inside the wire antennas.
FeRM Model for Time Series Forecasting
Authors: Vijayakumar Vibinkumar , Domanic Gifty , Ummar Shaik , Afsal Muhammed
Published: November 2022

Time series forecasting is a way of analyzing the data points indexed in time order and fitting a model to predict future values. Time series data can be hourly, daily, weekly, monthly, or sometimes annual. Time series analysis is used to understand the underlying trends and patterns over time to accurately predict future outcomes. Traditional models such as ARIMA, and deep learning models such as RNNs, Transformers are used for long-term forecasting of time series because they effectively utilize historical information. However, there is still great room for improvement when it comes to the situation where historical data for training is limited. In this paper, we demonstrate a novel time series model with better predictions where the traditional models failed to exploit in view of the fact that not all time series problems can be solved by the traditional models. To this end, our model incorporates the sum of Fourier extrapolation, Rate of change approximation and arithmetic Mean of data points that elicit better predictions and reduced errors which importantly outweighed the state-of-the-art models with little computational overhead.
Scaling up Gas and Electric Cooking in Low- and Middle-Income Countries: Climate Threat or Mitigation Strategy with co-Benefits?
Authors: Floess Emily , Grieshop Andrew , Puzzolo Elisa , Pope Daniel , Leach Nicholas , Smith Christopher J. , Gill-Wiehl Annelise , Landesman Katherine , Bailis Rob
Published: November 2022

Nearly 3 billion people in low- and middle-income countries (LMICs) rely on polluting fuels, resulting in millions of avoidable deaths each year. Polluting fuels also emit short-lived climate forcers and greenhouse gases (GHGs). Liquefied petroleum gas (LPG) and grid-based electricity are scalable alternatives to polluting fuels but have raised climate and health concerns. Here, we compare emissions and climate impacts of a business-as usual household cooking fuel trajectory to four large-scale transitions to gas and/or grid electricity in 77 LMICs. We use upstream and end-use emissions in a reduced-complexity emissions-based climate model to estimate radiative forcing and temperature changes associated with each scenario. We find full transitions to LPG and/or electricity decrease emissions from both well-mixed GHG and short-lived climate forcers, resulting in a roughly 5 mK global temperature reduction by 2040. Transitions to LPG and/or electricity also reduce annual emissions of PM2.5 by over 6 Mt (99%) by 2040, which would substantial lower health risks.
Next generation pan-cancer blood proteome profiling using proximity extension assay
Authors: Uhlen Mathias , Álvez María Bueno , Edfors Fredrik , von Feilitzen Kalle , Zwahlen Martin , mardinoglu adil , Edqvist Per-Henrik , Sjöblom Tobias , Lundin Emma , Rameika Natallia , Axelsson Tomas , Åberg Mikael , Nordlund Jessica , Zhong Wen , Karlsson Max , Gyllensten Ulf , Pontén Fredrik , Fagerberg Linn
Published: November 2022

Cancer is a highly heterogeneous disease in need of accurate and non-invasive diagnostic tools. Here, we describe a novel strategy to explore the proteome signature by comprehensive analysis of protein levels using a pan-cancer approach of patients representing the major cancer types. Plasma profiles of 1,463 proteins from more than 1,400 cancer patients representing altogether 12 common cancer types were measured in minute amounts of blood plasma collected at the time of diagnosis and before treatment. AI-based disease prediction models allowed for the identification of a set of proteins associated with each of the analyzed cancers. By combining the results from all cancer types, a panel of proteins suitable for the identification of all individual cancer types was defined. The results are presented in a new open access Human Disease Blood Atlas. The implication for cancer precision medicine of next generation plasma profiling is discussed.
Effects of a dendritic cell vaccine loaded with whole tumor antigen in hu-PBL-SCID mice bladder cancer
Authors: Wang Bin , Song Jiwen , Chen Huiqing
Published: November 2022

Background: The effects of dendritic cell (DC) vaccine loaded with whole tumor antigen on bladder cancer model in human peripheral blood lymphocytes (hu-PBL) -severe combined immunodeficient (SCID) mice was ivestigated.
Methods: The peripheral blood mononuclear cells (PBMCs) were isolated from human peripheral blood, and were induced into DCs by co-culture with recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin 4 (rhIL-4) in vitro. The DC vaccine were produced by co-culturing with whole tumor antigen which was purified through freezing and melting T24 cells. The animal model of tumor-bearing mice was established by SCID mice intraperitoneally injected with 4×107 hu-PBL and subcutaneously injected with 3×106 T24 cells. Animals were randomly allocated to an experimental group or control group. After T24 cells injected into SCID mice for 5 weeks, the mice were treated with DC vaccine or phosphate buffered saline (PBS). Human IgG level in the blood plasma of mice was detected by enzyme linked immunosorbent assay (EILSA), and human CD3+, CD4+, CD8+T cells in blood and spleen cells of mice were detected by flow cytometry (FCM) analysis. The tumor volume in each group were records. Matrix metalloproteinases-7 (MMP-7) mRNA expression in tumor tissue was detected by fluorescence quantitative reverse transcription polymerase chain reaction (FQ-RT-PCR).
Results and Conclusion: Tumor volumes and MMP-7 mRNA expression in tumor tissue of DC vaccine treated mice was statistically lower than PBS group (P<0.01). DC vaccine had an anti-tumor effect on hu-PBL-SCID mice bladder cancer model.
Phishing URL Detection Using CNN-LSTM and Random Forest Classifier
Authors: nepal sopnil , gurung hemant , nepal roshan
Published: November 2022

This paper presents the classification of phishing URL's apart from legitimate URL's with the use of machine learning and deep learning techniques. Phishing is defined as an act to steal the private information by pretending to be a legitimate entity which they are not. Machine learning model, Random Forest classifier is trained on the extracted features based on Address Bar, Domain and HTML and JavaScript of the URL. On the other hand, CNN-LSTM hybrid model was trained to learn the character sequence features of the given URL and make the classification. The dataset used was public data from Kaggle which was downloaded from their website. The dataset contained 11,430 URLs: 5,715 legitimate URLs and 5,715 phishing URL. Hereafter, we classified the URL of the current address bar as legitimate or phishing with the use of previously trained model. Thus, proposed paper focuses on the study and development of models for detection of phishing sites so that properties of various URLs can be learnt by feature extraction and can be classified as accurately as possible.
Pseudomembranous Colitis in a Coronavirus Disease 19 positive patient : not a simple issue.
Authors: Thayer Maissa Ben , Khanchel Fatma , Helal Imen , Zaafouri Haithem , Hedhli Raoueh , Brahim Ehsen Ben , Jouini Raja , Chadli-Debbiche Aschraf
Published: November 2022

Since its emergence, Coronavirus Disease (Covid-19) rapidly spread worldwide and was responsible for a global pandemic. Although it was initially considered a respiratory disease, recent studies have evidenced that Covid-19 had serious systemic adverse effects involving major organs, including those of the digestive system. Histological lesions associated with these manifestations have rarely been reported. We, herein, present a singular case of pseudomembranous colitis (PMC), proven histologically, in a 73-year-old Covid-19 positive female patient. We aim to study the clinico-pathological characteristics of this association. A 73-year-old Covid positive patient was intubated and put on intravenous antibiotherapy after the deterioration of her respiratory function. Ten days after admission, the patient presented abdominal distension and melena. An abdominal tomography scan showed a left mesenteric infarction related to a thrombosis at the origin of the left mesenteric artery. A left hemicolectomy was performed in emergency. Macroscopic examination of the hemicolectomy specimen showed an edematous colonic mucosa, with multiple ulcerations covered by a whitish necrotic coating reminiscent of false membranes. Histological examination confirmed the diagnosis of PMC. The patient presented a septic shock and died six days after the operation. The PMC could have resulted from the use of antibiotics. However, the direct involvement of Covid-19 in the occurrence of this PMC cannot be excluded. Further studies are needed to evaluate the direct correlation between Covid-19 and PMC.
Gunshot bullet trauma of the colon in combat patients injured in hybrid period of Russian-Ukrainian war during 2014-2020
Authors: Gumeniuk Kostiantyn , Lurin Igor A. , Tsema Ievgen , Malynovska Lesia , Gorobeiko Maksym , Dinets Andrii
Published: November 2022

Background
Gunshot wound to the colon is a frequent injury in armed conflicts. An example of high-energy modern weapon is hollow-point bullets, which is associated with an increased tissue damage and lethal outcome. The aim of this study was to evaluate gunshot injuries to the colon in combat patients and to investigate specific features of the hollow-point and shape-stable bullets features in colon injury.
Patients and methods
Analyses of clinical data was performed on 384 male soldiers from Armed Forces of Ukraine with gunshot abdominal wound with injury to the colon in East Ukraine between 2014 and 2020. Out of 374 injured, 112 (29.9%) patients were diagnosed with penetrating gunshot bullet wounds: 69/112 (61.6%) were injured by shape-stable bullets and 43/112 (38.4%) patients were injured by the hollow-point bullets.
Results
More severe hemorrhagic shock stages were in patients injured by hollow-point bullets: shock stages III-IV was in 25 (58.1%) patients injured by the hollow-point bullets vs. 17 (24.6%) patients injured by shape-stable bullets (p = 0.0004). Left colon parts were more frequently injured as compared to right colon side or transverse colon in 21 (48.8%) injured by shape-stable (p < 0.0001) and in 41 (59.4%) patients injured by the hollow-point bullets (p = 0.032). A significant difference was identified for the frequent injury to the middle colon within the entire cohort (p = 0.023). Patients injured with the hollow-point bullets demonstrated a higher frequency of 3–5 areas of colon penetration, which was detected in 18 (41.8%) patients injured by hollow-point bullets and none patients with shape-stable bullets injury (p = 0.0001). Colon Injury Scale (CIS) IV was detected in 9 (8%) patients injured by the hollow-point bullets as compared to 7 (10.1%) patients injured by shape-stable bullets (p = 0.031). Colostomy was performed in 9 (13%) patients injured by shape-stable bullets and in 8 (19%) patients injured by the hollow-point bullets (p > 0.05). 15 (35%) patients died after injury by the hollow-point bullet, whereas 9 (13%) patients after injury by the shape-stable bullets (p = 0.0089).
Conclusions
All patients should be suspected to have a hollow-point injury in case of penetrating injury (absent outlet wound) and careful revision of the abdomen must be performed to identify possible multiorgan injury as well as multiple perforations of the intestine.
Epidemiological characteristics of patients from fever clinics with COVID-19 epidemic in 2022 in Shanghai, China.
Authors: Zhang Yuanjing , Wang Jianrong , Xie Ying , Cao Xinghao , Huang Huili , Liu Qingyang , Hang Xiaofeng , Wang Junxue
Published: November 2022

The outbreak of COVID-19 in Shanghai, China, in March 2022, was caused by the Omicron variant. The epidemic lasted for more than 3 months, and the cumulative number of infected people reached 626,000. We aimed to investigate the impact of clinical factors on disease outcomes in patients with COVID-19. In this study, we collected fever clinics confirmed Omicron variant infection cases, analyzed their population and laboratory diagnostic characteristics, and provided theoretical support for subsequent epidemic prevention and control. The results of this study show that the COVID-19 vaccine can protect against Omicron variant infection, and more than 50% of infected people have not been vaccinated before. Compared with the epidemic in Wuhan 2 years ago, most of the patients in the hospital in the Shanghai epidemic had underlying diseases (P < 0.05). In the comparison between patients with Omicron variant epidemic in Shanghai and patients with respiratory tract infection, there was no significant difference in N%, L%, monocytes, eosinophils, RBC, HB, PLT, etc. (P > 0.05). People over 60 years old and with underlying diseases were the risk factors for pneumonia [HR: 14.62 (5.49–38.92), P < 0.001; HR = 5.29 (2.58–10.85), P < 0.001, respectively]. But vaccination was a protective factor [HR = 0.24 (0.12–0.49), P < 0.001]. In summary, it was confirmed that the vaccine has an effect on the infection of Omicron variant strains and the protection against pneumonia. The virus damage of Omicron variant strains has a significant downward trend compared with 2 years ago.