bluuebunny/crossref_metadata_2025 huggingface dataset:
Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models
Authors: Yusuf Issa O. , Qiao Tao , Parsi Sepideh , Tilvawala Ronak , Thompson Paul R. , Xu Zuoshang
Published: September 2022

Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD) activity have been observed in several neurodegenerative diseases. PC is a posttranslational modification catalyzed by the PADs. PC converts peptidyl-arginine to peptidyl-citrulline, thereby reducing the positive charges and altering structure and function of proteins. Of the five PADs, PAD2 is the dominant isoform in the central nervous system (CNS). Abnormal PC and PAD dysregulation are associated with numerous pathological conditions, including inflammatory diseases and neurodegeneration. Animal model studies have shown therapeutic efficacy from inhibition of PADs, thus suggesting a role of PC in pathogenesis. To determine whether PC contribute to amyotrophic lateral sclerosis (ALS), a deadly neurodegenerative disease characterized by loss of motor neurons, paralysis, and eventual death, we investigated alterations of PC and PAD2 in two different transgenic mouse models of ALS expressing human mutant SOD1G93A and PFN1C71G, respectively. PC and PAD2 expression are altered dynamically in the spinal cord during disease progression in both models. PC and PAD2 increase progressively in astrocytes with the development of reactive astrogliosis, while decreasing in neurons. Importantly, in the spinal cord white matter, PC accumulates in protein aggregates that contain the myelin proteins PLP and MBP. PC also accumulates progressively in insoluble protein fractions during disease progression. Finally, increased PC and PAD2 expression spatially correlate with areas of the CNS with the most severe motor neuron degeneration. These results suggest that altered PC is an integral part of the neurodegenerative process and potential biomarkers for disease progression in ALS. Moreover, increased PC may contribute to disease-associated processes such as myelin protein aggregation, myelin degeneration, and astrogliosis.
Hyperspectral imaging solutions for the non-invasive detection and automated mapping of copper trihydroxychlorides in ancient bronze
Authors: Liggins Florence , Vichi Alessandra , Liu Wei , Hogg Alexander , Kogou Sotiria , Chen Jianli , Liang Haida
Published: September 2022

Ancient bronze is subject to complex degradation which can lead, in cases where copper chlorides are present, to a cyclic and self-sustaining degradation process commonly referred to as “bronze disease”. If left untreated, bronze disease can eat away at a bronze object until it is entirely deteriorated. The presence of copper trihydroxychlorides is indicative that this process is underway and therefore the detection of these corrosion products is necessary in guiding conservation of ancient bronze artefacts. In this paper we present a high spatial/spectral resolution short wave infrared (SWIR) imaging solution for mapping copper trihydroxychlorides in ancient bronze, combining hyperspectral imaging with an in-house developed unsupervised machine learning algorithm for automated spectral clustering. For this work, verification was obtained through use of an in-house developed reference database of typical ancient bronze corrosion products from several archaeological sites, and from collections of the National Museum of China. This paper also explores the suitability, and limitations, of a visible to near-infrared (VNIR) hyperspectral imaging system as a more accessible solution for mapping copper trihydroxychlorides associated with bronze disease. We suggest that our hyperspectral imaging solution can provide a non-invasive, rapid, and high resolution material mapping within and across bronze objects, particularly beneficial for analysing large collections in a museum setting.
Conventional and advanced exergy analysis of a single flash geothermal cycle
Authors: Tang Xianzhi , Yan Gongxing , Abed Azher M. , Sharma Aman , Tag-Eldin Elsayed , Aryanfar Yashar , Alcaraz Jorge Luis García
Published: September 2022

In this paper, the inefficiency of the studied energy conversion system is identified to reduce losses and improve performance. A conventional exergy analysis has limitations that it is not able to detect and this detection is done with advanced exergy analysis. The main role of advanced exergy analysis is to help engineers improve system design and performance by providing information. This provision of information is done by isolating the exergy destruction. Separation of exergy destruction into endogenous/exogenous and unavoidable/avoidable components presents a new development in the exergy analysis of energy conversion systems, which in this paper combines both concepts. This separation increases the accuracy of the exergy analysis and facilitates the improvement of a system. The method used in this paper for separation is the thermodynamic cycle method, which is based on determining the temperature levels for ideal and irreversible cycles.

Graphical Abstract
Median sternotomy approach for the repair of esophageal atresia: a case report
Authors: Fukuzawa Hiroaki , Okamoto Mitsumasa , Tsuruno Yudai , Maruo Ayako
Published: September 2022

Background

Repair of esophageal atresia is usually performed through the right thoracic cavity. However, when the upper pouch of the esophagus and tracheoesophageal fistula (TEF) is located in the thoracic inlet and completely on the left side of trachea, it is difficult to dissect and anastomose the esophagus through the right thoracic cavity. We present a case of esophageal atresia, with the esophageal upper pouch located high and completely on the left side of trachea, successfully repaired via the median sternotomy approach.

Case presentation

A male neonate with a birth weight of 1766 g was prematurely delivered via cesarean section at 34 weeks of gestation. Contrast-enhanced computed tomography (CT) showed that the upper pouch of the esophagus was located at the thoracic inlet and completely on the left side of the trachea; hence, a diagnosis of esophageal atresia was made. Moreover, a TEF was connected to the trachea at the level of the lower end of the upper esophageal pouch. An aberrant right subclavian artery and persistent left superior vena cava were also detected. Esophageal dissection and anastomosis were determined to be very difficult if approached from the right thoracic cavity. Therefore, we performed median sternotomy one day after the neonate was born. The upper pouch of the esophagus and TEF were easily dissected via the median sternotomy approach. Anastomosis of the esophagus was performed, with a good visual field, to the left of the trachea. The postoperative course was uneventful.

Conclusions

This is the first reported case of a median sternotomy approach for esophageal atresia. This technique may be useful when a right thoracic approach is difficult, especially if the esophageal upper pouch is located completely to the left of the trachea or if it is higher than the normal position.
The core bacterial microbiome of banana (Musa spp.)
Authors: Birt Henry W. G. , Pattison Anthony B. , Skarshewski Adam , Daniells Jeff , Raghavendra Anil , Dennis Paul G.
Published: September 2022

Background

Bananas (Musa spp.) are a globally significant crop and are severely afflicted by diseases for which there are no effective chemical controls. Banana microbiomes may provide novel solutions to these constraints but are difficult to manage due to their high diversity and variability between locations. Hence ‘common core’ taxa, which are a subset of the microbiome that frequent all, or most, individuals of a host species, represent logical targets for the development of microbiome management approaches. Here, we first performed a pot experiment to characterise the effects of two factors that are likely to differ between farms (viz. edaphic conditions and host genotype) on bacterial diversity in bulk soil and seven plant compartments. From this experiment, we created shortlisted core ‘candidates’ that were then refined using a survey of 52 field-grown Musa spp. We confirmed the importance of the core through network analysis and by comparing the sequences of our core taxa with those reported in 22 previous studies.

Results

Diversity was found to differ between plant compartments and soils, but not genotypes. Therefore, we identified populations that were frequent across most plants irrespective of the soil in which they were grown. This led to the selection of 36 ‘common core’ bacteria, that represented 65–95% of the dominant taxa in field-grown plants and were identified as highly interconnected ‘hubs’ using network analysis – a characteristic shown to be indicative of microbes that influence host fitness in studies of other plants. Lastly, we demonstrated that the core taxa are closely related to banana-associated bacteria observed on five other continents.

Conclusions

Our study provides a robust list of common core bacterial taxa for Musa spp. Further research may now focus on how changes in the frequencies and activities of these most persistent taxa influence host fitness. Notably, for several of our core taxa, highly similar populations have already been isolated in previous studies and may be amenable to such experimentation. This contribution should help to accelerate the development of effective Musa spp. microbiome management practices.
Alpha radionuclide-chelated radioimmunotherapy promoters enable local radiotherapy/chemodynamic therapy to discourage cancer progression
Authors: Zhang Jiajia , Li Feize , Yin Yuzhen , Liu Ning , Zhu Mengqin , Zhang Han , Liu Weihao , Yang Mengdie , Qin Shanshan , Fan Xin , Yang Yuanyou , Zhang Kun , Yu Fei
Published: September 2022

Background

Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis and relapse. Combined immune checkpoint blockade (ICB) with chemodynamic therapy (CDT) could boost antitumor immunity, which may magnify the immune responses of TAT. This study aims to discourage tumor metastasis and relapse by tri-model TAT-CDT-ICB strategy.

Methods

We successfully designed Mn-based radioimmunotherapy promoters (
211
At-ATE-MnO
2
-BSA), which are consisting of
211
At, MnO
2
and bovine serum albumin (BSA). The efficacy of
211
At-ATE-MnO
2
-BSA was studied as monotherapy or in combination with anti-PD-L1 in both metastatic and relapse models. The immune effects of radioimmunotherapy promoters on cytotoxic T lymphocytes and dendritic cells (DCs) were analyzed by flow cytometry. Enzyme-linked immunosorbent assay and immunofluorescence were used to explore the underlying mechanism.

Results

Such radioimmunotherapy promoters could not only enhance the therapeutic outcomes of TAT and CDT, but also induce robust anti-cancer immune activity by activating dendritic cells. More intriguingly,
211
At-ATE-MnO
2
-BSA could effectively suppress the growths of primary tumors and distant tumors when combined with immune checkpoint inhibitors.

Conclusions

The tri-model TAT-CDT-ICB strategy provides a long-term immunological memory, which can protect against tumor rechallenge after eliminating original tumors. Therefore, this work presents a novel approach for TAT-CDT-ICB tri-modal cancer therapy with repressed metastasis and relapse in clinics.
Time series aggregation for energy system design: review and extension of modelling seasonal storages
Authors: Blanke Tobias , Schmidt Katharina S. , Göttsche Joachim , Döring Bernd , Frisch Jérôme , van Treeck Christoph
Published: September 2022

Using optimization to design a renewable energy system has become a computationally demanding task as the high temporal fluctuations of demand and supply arise within the considered time series. The aggregation of typical operation periods has become a popular method to reduce effort. These operation periods are modelled independently and cannot interact in most cases. Consequently, seasonal storage is not reproducible. This inability can lead to a significant error, especially for energy systems with a high share of fluctuating renewable energy. The previous paper, “Time series aggregation for energy system design: Modeling seasonal storage”, has developed a seasonal storage model to address this issue. Simultaneously, the paper “Optimal design of multi-energy systems with seasonal storage” has developed a different approach. This paper aims to review these models and extend the first model. The extension is a mathematical reformulation to decrease the number of variables and constraints. Furthermore, it aims to reduce the calculation time while achieving the same results.
Types of indigenous vegetables consumed, preparation, preferences and perceived benefits in Ghana
Authors: Atuna Richard A. , Djah Jemima , Achaglinkame Matthew A. , Bakker Sanne , Dari Linda , Osei-Kwarteng Mildred , Mahunu Gustav K. , Koomen Irene , Amagloh Francis K.
Published: September 2022

Indigenous vegetables (IVs) are rich sources of essential nutrients, particularly vitamins and minerals, and other non-nutritive phytochemicals. IVs play a critical role in the food culture of the Ghanaian people. Despite their importance, they have over the years been mostly associated with the resource-poor. In this study, the types of IVs, preparation preferences, frequency of consumption and some perceived benefits ascribed by some Ghanaian consumers (n = 1393) were investigated in a cross-sectional survey. Descriptive analysis and a chi-square test of independence were conducted to summarise and determine the relationship between gender, age and consumption frequency of the IVs. The study identified okra (Abelmoschus esculentus), cocoyam (Xanthosoma sagittifolium) leaves, jute mallow (Corchorus olitorius) and garden egg (Solanum melongena) as the popular IVs consumed by respondents. Among these, about 13.3% of women and 15.3% of men indicated they consume okra. Eight per cent of the women respondents and 6.7% of the men consumed jute mallow. Almost 57% of the respondents said the IVs were used to prepare stew and soup. More than a third (39%) of the respondents indicated that they consumed the IVs either daily or more than once a week. Women respondents’ frequency of IVs consumption was significantly different [X2 (4, n = 1393) = 30.11, p = 0.000] from the men. The frequency of consumption of IVs for the elderly was significantly higher [X2 (12, n = 1393) = 30.53, p = 0.002] as compared to the younger respondents. The main perceived benefits of IVs were nutrition- and health-related. The major barriers to the consumption of IVs were cost, non-availability, palatability and cultural. The IVs were largely wet-cooked and consumed as stews or sauces and soups. These findings form good bases for further empirical studies on the nutritional and other health-benefiting attributes of the specific IVs found in this study for sustainable promotion and utilisation in Ghana.
Research on co-disposal and utilization of ferrous packaging containers contaminated with hazardous wastes by steel converter
Authors: Wang Yi , Chen Junfu , Fu Benquan , Zhang Lei , Liu Heng , Huang Yanjun , Song Guangsen
Published: September 2022

The disposal of waste oil, paint and coating barrels (WOPCBs) after use is an ongoing social and environmental problem. In this paper, a novel technological scheme using steel converter co-processing is proposed for the safe disposal and resource utilization of WOPCBs. The scheme is mainly composed of WOPCBs pretreatment and converter disposal, focusing on the impact of converter co-processing WOPCBs on the environment and production process. Compared to the traditional technology, the scheme presented takes full advantages of the production process and environmental protection facilities of steel converter, and has many advantages, such as a large disposal capacity, low cost, highly efficient and environmentally friendly. The industrial trials results show that after adding 180–540 kg WOPCBs to each furnace load (nominal capacity 250 t), the converter operation is safe and controllable, and all the pollutant emission indicators generated in the process meet the Chinese national standards. In addition, WOPCBs are suitable to be used as a supplementary material for scrap steel. Therefore, this study provides important insights for sustainable resource utilization from WOPCBs.
Outcomes of urgent coronary artery bypass grafting in patients who have recently recovered from COVID-19 infection, with a median follow-up period of twelve months: our experience
Authors: Bhattacharya Sudipto , Bandyopadhyay Ashok , Pahari Satyabrata , Das Sankha , Dey Ashim Kumar
Published: September 2022

Background

The Coronavirus disease 2019 (COVID-19) was declared a worldwide pandemic in 2020 by the World Health Organization (WHO). Certain individuals are at higher risk, (age > 65 years, pre-existing lung or heart conditions, diabetes and obesity) especially those requiring cardiac surgery, including Coronary Artery Bypass Grafting (CABG). Here we present a case series of 11 patients, operated between April 2020 and April 2022, all of whom had recently recovered from COVID-19, who presented with unstable angina, and therefore required urgent Coronary Artery Bypass Grafting (CABG). Similar cases reported in the past, have had a high morbidity and mortality rate.

Case presentation

The study included 11 males, and their age varied between 53 and 68 years (median of 65 years). They were either partially or fully vaccinated. All of them had a history of recent mild COVID-19 infection. The European system for cardiac operative risk evaluation, EuroSCORE II in-hospital mortality risk at admission, varied between 1.48% and 5.12%. Six out of 11 patients (54.55%) had a recent Acute Coronary Syndrome (ACS) which is associated with a higher risk and poor prognosis. All of them underwent urgent CABG (10 of them, 90.91% cases, using the off-pump technique and one patient had to be converted to the on-pump beating heart surgery technique during surgery). Ten of the 11 patients were operated using the off-pump technique, and there was one death (9.09%). All surviving patients made an uneventful recovery and have been followed up with a median follow-up period of 12 months.

Conclusions

Previous studies on a similar group of patients have resulted in high morbidity and mortality. A conscious effort was made to perform all surgeries off-pump, thereby eliminating the inflammatory effects and other hazards of cardiopulmonary bypass in this case series, with only one out of 11 (9.09%) being converted to the on-pump beating heart technique due to the hemodynamic instability faced during surgery. Our findings show a mortality rate of 9.09%, with the surviving patients doing well at a median follow-up period of 12 months, suggesting that it is a safe procedure in this patient subset.
Differences in Pretreatment Frailty Across Gastrointestinal Cancers in Older Adults: Results From the Cancer and Aging Resilience Evaluation Registry
Authors: Arora Sankalp , Fowler Mackenzie E. , Harmon Christian , Al-Obaidi Mustafa , Outlaw Darryl , Hollis Robert , Gbolahan Olumide , Khushman Moh'd , Giri Smith , Williams Grant R.
Published: September 2022

PURPOSE:

Frailty predicts poor outcomes in older adults with cancer, but how it differs between different cancer types is unknown. We examined differences in pretreatment frailty between colorectal (CRC), pancreatic, and hepatobiliary cancers.

METHODS:

We included older adults age 60 years or older with the above cancer types enrolled in the Cancer and Aging Resilience Evaluation registry. Frailty was defined using a 44-item Cancer and Aging Resilience Evaluation frailty index constructed on the basis of the principles of deficit accumulation (including several geriatric assessment impairments encompassing malnutrition, functional status, comorbidities, anxiety, depression, cognitive complaints, health-related quality of life, falls, ability to walk one block, interference in social activities, and polypharmacy). Multivariable logistic regression models were used to examine the adjusted odds ratio (aOR) of frailty between cancer types.

RESULTS:

A total of 505 patients were included (mean age 70 years, 59% male): 211 (41.8%) CRC, 178 (35.2%)pancreatic cancer, and 116 (23.0%) hepatobiliary cancer. Patients with pancreatic cancer had the highest prevalence of frailty (23.3% CRC, 40.6% pancreatic, 34.3% hepatobiliary; P = .001). Both pancreatic (aOR, 2.18; 95% CI, 1.38 to 3.45), and hepatobiliary cancer (aOR, 1.73; 95% CI, 1.03 to 2.93) were independently associated with higher odds of frailty relative to CRC. Frailty was driven by higher rates of malnutrition and instrumental activities of daily living impairments in patients with pancreatic cancer and higher number of comorbidities in patients with hepatobiliary cancer.

CONCLUSION:

Older adults with pancreatic and hepatobiliary cancers are at high-risk of pretreatment frailty. Early interventions to improve nutritional and functional status and optimization of comorbidities may help improve outcomes.
Toward a “Global” History of Music Theory
Authors: Martin Nathan John
Published: September 2022

The history of music theory, as it has usually been taught in the United States, has focused on a small canon of texts written mostly in Latin, Italian, French, and German. This article advocates a more expansive view of the subdiscipline's remit by way of three case studies. The first considers the distinction that Abū Naṣr Muḥammad ibn Muḥammad al-Fārābī draws between the speculative and active parts of music theory and its influence on the formation of the discipline in the Latin-speaking world. The second considers entanglement between French and Chinese music theorizing in the later eighteenth century. The third treats the international contexts of Hugo Riemann's thought. I present these three case studies, together with more general reflections on the possible scope of research on historical music theory, with the aim of inviting reflection on the subdiscipline's past, present, and future.
Interpretive Difficulty and Emergent Structure in Contemporary Music
Authors: Duinker Ben
Published: September 2022

This article explores the notion of interpretive difficulty in contemporary music, treating it as a structural, tangible aspect of analysis. Interpretive difficulty comprises any challenge a performer may encounter—physical, cognitive, emotional, specific to a musical passage, or generalized across a repertoire or performance idiom. Five professional performers who specialize in contemporary music are interviewed about their experiences learning and performing specific works—Crimson (Rebecca Saunders, 2005), Taurangi (Gillian Whitehead, 1999), Mani.Δίκη (Pierluigi Billone, 2012), Sept papillons (Kaija Saariaho, 2000), and La Nativité du Seigneur (Olivier Messiaen, 1935)—focusing on how interpretive difficulty and musical structure intersect in their practice. These interviews illuminate a relationship between interpretive difficulty and musical structure that manifests in several domains: accuracy, interpretive latitude, narrative, and control. While difficulty is uniquely determined by any musician's physical, cognitive, environmental, or cultural context, using these domains as a theoretical framework establishes relationships among works, performers, and idioms that might otherwise appear to have little in common—a particularly appealing prospect for recently composed repertoire. In subscribing to Nicholas Cook's (2013) recharacterization of the score as a “script” that is interpreted, supplemented, and molded in performance, this research encourages the treatment of performers' contributions as a fundamental object of analysis.
Targeting firing rate neuronal homeostasis can prevent seizures
Authors: Mulroe Fred , Lin Wei-Hsiang , Mackenzie-Gray Scott Connie , Aourz Najat , Fan Yuen Ngan , Coutts Graham , Parrish R. Ryley , Smolders Ilse , Trevelyan Andrew , Wykes Robert C. , Allan Stuart , Freeman Sally , Baines Richard A.
Published: September 2022

Manipulating firing-rate neuronal homeostasis, which enables neurons to regulate their intrinsic excitability, offers an attractive opportunity to prevent seizures. However, to date, no drug-based interventions have been reported that manipulate this type of neuronal homeostatic mechanism. Here, we used a combination of Drosophila and mouse, and, in the latter, both a pentylenetetrazole (PTZ)-induced seizure model and an electrically induced seizure model for refractory seizures to evaluate the anticonvulsant efficacy of a novel class of anticonvulsant compounds, based on 4-tert-butyl-benzaldehyde (4-TBB). The mode of action included increased expression of the firing rate homeostatic regulator Pumilio (PUM). Knockdown of pum expression, in Drosophila, blocked anticonvulsive effects of 4-TBB, while analysis of validated PUM targets in mouse brain revealed significant reductions following exposure to this compound. A structure-activity study identified the active parts of the molecule and, further, showed that the pyrazole analogue demonstrates highest efficacy, being active against both PTZ-induced and electrically induced seizures. This study provides a proof of principle that anticonvulsant effects can be achieved through regulation of firing rate neuronal homeostasis and identifies a possible chemical compound for future development.
Synergizing liver systemic treatments with interventional oncology: friend or foe?
Authors: Jost Raphaël , Al-Shatti Nael , Ghosn Mario , Bonnet Baptiste , Champiat Stephane , Deschamps Frederic , Gelli Maximiliano , Boige Valérie , Danlos Francois-Xavier , Susini Sandrine , Hollebecque Antoine , Ammari Samy , Marabelle Aurelien , de Baere Thierry , Tselikas Lambros
Published: September 2022

Interventional radiology techniques provide excellent local tumor control for small tumors in various organs, but several limitations can hamper the oncological outcomes such as the tumor size or the number of lesions. Technical improvements, optimal patient selection and combination with systemic therapies, including immune checkpoint inhibitors, have been successfully developed to overcome these barriers.

In this setting, chemotherapy and targeted therapies aim to diminish the tumor burden in addition to local treatments, while immunotherapies may have a synergistic effect in terms of mechanism of action on the tumor cell as well as the immune environment, with multiple treatment combinations being available. Finally, interventional Rrdiology treatments often increase tumor antigen exposure to the immune system, and thus stimulate a specific antitumor immune response that can act beyond the treated site. Notwithstanding their many benefits, combination treatment may also result in complications, the most feared may be auto-immune-related adverse events.

In early studies, several combined therapies have shown promising levels of safety and efficacy, particularly in hepatocellular carcinoma.

This review provides a comprehensive and up-to-date overview of results of combined therapies for primary and secondary liver malignancies. Recent advances and future perspectives will be discussed.
Η μνήμη της αριστερής ήττας στον μεταπολιτευτικό κινηματογράφο: Η Κάθοδος των εννιά από το χαρτί στην οθόνη
Authors: Βαγγελοκώστας Γιάννης
Published: September 2022

Η κάθοδος των εννιά (1984) του Χρίστου Σιοπαχά, κινηματογραφική μεταφορά του ομώνυμου αφηγήματος του Θανάση Βαλτινού (1963), ανήκει σε μια διακριτή ομάδα ιστορικοπολιτικών ταινιών του Νέου Ελληνικού Κινηματογράφου, οι οποίες συνέβαλαν στη διαμόρφωση της κοινωνικής μνήμης του Εμφυλίου κατά την πρώτη μεταπολιτευτική περίοδο. Θέτοντας ως κεντρικό ερευνητικό άξονα την αναπαράσταση της ήττας της αριστερής παράταξης το άρθρο εξετάζει τη διακειμενική σχέση της ταινίας με τη λογοτεχνική της πηγή. Η ανάλυση θεμελιώνεται θεωρητικά στις προσεγγίσεις οι οποίες υπερβαίνοντας το αξιολογικό κριτήριο της πιστότητας του φιλμικού στο λογοτεχνικό κείμενο αντιλαμβάνονται τις κινηματογραφικές μεταφορές ως λογοθετικές πρακτικές, τοποθετημένες σε συγκεκριμένα ιστορικά, ιδεολογικά και πολιτισμικά συμφραζόμενα. Μέσα σε αυτό το ερμηνευτικό πλαίσιο εντάσσεται και η συζήτηση για την ιδεολογικοποιημένη μεταπολιτευτική πρόσληψη του βαλτινικού κειμένου ως αριστερής μαρτυρίας για τον Εμφύλιο, την οποία η παρούσα ανάλυση επιχειρεί να αναδείξει σε σημαντικό στοιχείο του ευρύτερου πολιτισμικού συγκειμένου της ταινίας.
Μνήμη και νοσταλγία στον νέο ελληνικό κινηματογράφο: Ο εξόριστος στην κεντρική λεωφόρο και Τα κουρέλια τραγουδάνε ακόμα
Authors: Καλούδη Κωστούλα
Published: September 2022

Στις ταινίες Ο εξόριστος της κεντρικής λεωφόρου και Τα κουρέλια τραγουδάνε ακόμα, συναντάμε το θέμα της μνήμης και της νοσταλγίας. Οι ήρωες απογοητευμένοι αναπολούν το παρελθόν τους και βρίσκουν καταφύγιο στις αναμνήσεις τους μέχρι που συνειδητοποιούν πως πια όλες οι ευκαιρίες έχουν χαθεί. Και στις δύο ταινίες, το περιθώριο και η αντικουλτούρα αποτελούν στάση ζωής. Η μυθολογία της ροκ μουσικής, η αγάπη για τον κινηματογράφο, η απόρριψη των κοινωνικών κανόνων αποτελούν αναφορές και δημιουργούν ένα ξεχωριστό τόπο μνήμης.
Μνήμη, λήθη και προφορικές μαρτυρίες στο σύγχρονο ελληνικό «ντοκιμαντέρ μνήμης», Ματαρόα: Το ταξίδι συνεχίζεται (2019) του Ανδρέα Σιαδήμα
Authors: Μυλωνάκη Αγγελική
Published: September 2022

Το άρθρο, ως μελέτη περίπτωσης, αναλύει από τη σκοπιά της δημόσιας ιστορίας, το ντοκιμαντέρ Ματαρόα - Το ταξίδι συνεχίζεται (2019), σε σκηνοθεσία Ανδρέα Σιαδήμα, που επαναφέρει στη συλλογική μνήμη ένα υποφωτισμέ- νο ιστορικό γεγονός: τo περιπετειώδες ταξίδι 150 Ελλήνων φοιτητών και φοιτητριών από τον Πειραιά για την Ιταλία και από εκεί για το Παρίσι, όπου «φυγαδεύτηκαν» το Δεκέμβριο του 1945 με το οπλιταγωγό Ματαρόα, ως υπότροφοι του γαλλικού κράτους, με πρωτοβουλία του διευθυντή του Γαλλικού Ινστιτούτου Αθηνών Οκτάβιου Μερλιέ, προκειμένου να διαφύγουν από τη μετά-κατοχική Ελλάδα και να κερδίσουν μια δεύτερη ευκαιρία για επιστημονική και επαγγελματική ανέλιξη, μακριά από εθνικές, ιδεολογικό-πολιτικές και πολιτισμικές διενέξεις. Η εργασία εξετάζει την κινηματογραφική διαχείριση της μνήμης για τη σύγχρονη ιστορία αξιοποιώντας το παράδειγμα ενός «ντοκιμαντέρ μνήμης», όπως αυτό του Σιαδήμα, που παρουσιάζει πώς το παρελθόν μπορεί να χρησιμοποιηθεί ως πυξίδα για το παρόν και το μέλλον και να προτείνει στους θεατές νέες προοπτικές για ενδομεσικές και διαμεσικές αναγνώσεις ενός ιστορικού γεγονότος.
Η ταινία ως αρχείο: η αναπαραγωγή της Ιστορίας και της μνήμης στον Θ. Αγγελόπουλο
Authors: Στάθη Ειρήνη
Published: September 2022

Η προετοιμασία και η δημιουργία μιας ταινίας με ιστορικό ή αυτοναφορικό περιεχόμενο ακολουθεί μια λογική παρόμοια, αν όχι ίδια, με αυτήν της αρχειοενεργοποίησης (όπως επισημαίνει ο Eric Ketellar) διαφοροποιώντας την από την εν συνεχεία τοποθέτηση με σειρά ιεραρχίας, η οποία ακολουθεί με τη λήψη και την ηχογράφηση, αποδίδοντας μια καλύτερη κατανόηση του πώς οι σιωπηρές αφηγήσεις του αρχείου γίνονται ρητές αφηγήσεις μέσα στην ταινία. Το αρχείο αντικατοπτρίζει την πραγματικότητα, όπως την αντιλαμβάνονται οι «archivers». Ομοίως, η ταινία αντικατοπτρίζει την πραγματικότητα, όπως την αντιλαμβάνονται οι δημιουργοί της. Σε κάθε περίπτωση, η έννοια της αρχειοθέτησης στη δημιουργία ταινιών ισοδυναμεί με το «πάθος για το παρελθόν» και την «ανασκαφή» της μνήμης. Σήμερα, ιστορικοί και θεωρητικοί του κινηματογράφου θεωρούν ότι είναι όλο και πιο αποδεκτό να προσεγγίζουμε ταινίες μυθοπλασίας ως αντανακλάσεις του παρελθόντος. Στη μεταμοντέρνα κατανόηση, τα όρια μεταξύ ταινίας και ιστορίας εξαφανίζονται. Οι ιστορικοί έχουν δεχθεί τις αφηγηματικές στρατηγικές και τα φανταστικά στοιχεία στη συγγραφή της ιστορίας, και οι θεωρητικοί της ταινίας βλέπουν το χάσμα μεταξύ της μυθοπλασίας και της τεκμηρίωσης να εξαφανίζεται. Οι ταινίες μυθοπλασίας, όσο και οι ταινίες τεκμηρίωσης, μπορούν να θεωρηθούν ως ένα είδος ιστορικού αρχείου. Τα όρια μεταξύ ταινιών και αρχείων σε αυτό το επίπεδο, επίσης εξαφανίζονται. Ο Godard έλεγε ότι ο κινηματογράφος είναι το μέσο που χρησιμοποιούμε για να γράψουμε ιστορία και ταυτόχρονα ότι ο κινηματογράφος διαμορφώνει τη μοναδική του ιστορία κατά την υλοποίησή του. Θα μπορούσε επίσης να μας προσφέρει τρόπους δημιουργίας ιστορίας. Το αρχείο είναι ο κατάλληλος τόπος που διευκολύνει την υλοποίηση ενός τέτοιου εγχειρήματος. Μέσα από το παρόν κείμενο διερευνώνται οι σχέσεις αρχείου και ταινίας, αλλά και η έννοια της ταινίας ως αρχείου στο έργο του Θόδωρου Αγγελόπουλου.
Ο κινηματογράφος ως πολιτισμική κατασκευή και ως κοινωνική πρακτική
Authors: Σηφάκη Ειρήνη
Published: September 2022

Η σχέση ιστορίας και κινηματογράφου αποτελεί ένα διεπιστημονικό πεδίο που περιλαμβάνει τόσο τις αναπαραστάσεις της κοινωνίας, όπως προβάλλονται μέσα από τις ταινίες των δημιουργών, όσο και τις συμβολικές αξίες των έργων τους. Ως συλλογικό πολιτιστικό προϊόν, ο κινηματογράφος διαμορφώνεται και επηρεάζεται από τις κύριες πολιτικές, οικονομικές και ιδεολογικές δυνάμεις της εκάστοτε εποχής. Οι εξωγενείς παράγοντες στο ευρύτερο κοινωνικοπολιτικό περιβάλλον, καθώς και οι μετασχηματισμοί που προκύπτουν στο εσωτερικό του πολιτισμικού πεδίου, καθορίζουν σε μεγάλο βαθμό το είδος και τη μορφή του παραγόμενου προϊόντος. Το κείμενο αυτό επιχειρεί να συμβάλει στο θεωρητικό διάλογο σχετικά με τη συνάντηση κινηματογράφου και ιστορίας, ενισχύοντας τη θεματική αναφορικά με τον τρόπο που οι θεσμικοί και διεθνικοί παράγοντες, όπως τα δίκτυα συνεργασίας και τα κινηματογραφικά Φεστιβάλ, μπορούν να επηρεάσουν τις στιλιστικές και αφηγηματικές τεχνικές των δημιουργών αλλά και στην τοποθέτησή τους στον χάρτη της παγκόσμιας ιστοριογραφίας. Προς επίρρωση των παραπάνω, δίδονται παραδείγματα από το πλαίσιο και τις συνθήκες ανάδυσης ενός νέου κύματος στον σύγχρονο ελληνικό κινηματογράφο.
El anhelo de libertad en Hannah Arendt.
Authors: Losada Sanz Milagros
Published: September 2022

El contenido del concepto “libertad” en Arendt rebasa la propia experiencia existencial que se tenga al respecto. Anclado en un rico planteamiento antropológico, no pierde su naturaleza política, para, haciendo honor a la esencia del concepto, convertirse en alimento para la esperanza; sin desdeñar una crítica, siempre en guardia, a todo aquello que pueda poner en peligro la posibilidad valiosa que posee el ser humano: la capacidad de ser libres.
Derivas contemporáneas del pensamiento político de Hannah Arendt.
Authors: Portas Pérez Teresa
Published: September 2022

Este artículo estudia la recepción del pensamiento de Hannah Arendt en la teoría feminista. Nos centraremos concretamente en las lecturas acerca del problema de la cuestión social y la corporalidad íntimamente relacionados. Más allá de las lecturas en las que se la consideraba una “nostálgica de la polis” y, en consecuencia, su pensamiento era calificado de elitista y continuista respecto a la lógica patriarcal, la complejidad en aumento de los postulados feministas y una lectura más sofisticada de los conceptos arendtianos, permitirán que sea leída como una nueva vía de acceso para repensar la esfera pública y la cuestión de las identidad
Wielopoziomowy model emocji w strukturze osobowości kulturowej. Perspektywa kulturalistyczna
Authors: Korporowicz Leszek
Published: September 2022

No abstract is avaliable for this article.
Many-Server Heavy-Traffic Limits for Queueing Systems with Perfectly Correlated Service and Patience Times
Authors: Yu Lun , Perry Ohad
Published: September 2022

We characterize heavy-traffic process and steady-state limits for systems staffed according to the square-root safety rule, when the service requirements of the customers are perfectly correlated with their individual patience for waiting in queue. Under the usual many-server diffusion scaling, we show that the system is asymptotically equivalent to a system with no abandonment. In particular, the limit is the Halfin-Whitt diffusion for the [Formula: see text] queue when the traffic intensity approaches its critical value 1 from below, and is otherwise a transient diffusion, despite the fact that the prelimit is positive recurrent. To obtain a refined measure of the congestion due to the correlation, we characterize a lower-order fluid (LOF) limit for the case in which the diffusion limit is transient, demonstrating that the queue in this case scales like [Formula: see text]. Under both the diffusion and LOF scalings, we show that the stationary distributions converge weakly to the time-limiting behavior of the corresponding process limit.

Funding: This work was supported by the National Natural Science Foundation of China [Grant 72188101] and the Division of Civil, Mechanical and Manufacturing Innovation [Grants 1763100 and 2006350].
Stochastic Zeroth-Order Riemannian Derivative Estimation and Optimization
Authors: Li Jiaxiang , Balasubramanian Krishnakumar , Ma Shiqian
Published: September 2022

We consider stochastic zeroth-order optimization over Riemannian submanifolds embedded in Euclidean space, where the task is to solve Riemannian optimization problems with only noisy objective function evaluations. Toward this, our main contribution is to propose estimators of the Riemannian gradient and Hessian from noisy objective function evaluations, based on a Riemannian version of the Gaussian smoothing technique. The proposed estimators overcome the difficulty of nonlinearity of the manifold constraint and issues that arise in using Euclidean Gaussian smoothing techniques when the function is defined only over the manifold. We use the proposed estimators to solve Riemannian optimization problems in the following settings for the objective function: (i) stochastic and gradient-Lipschitz (in both nonconvex and geodesic convex settings), (ii) sum of gradient-Lipschitz and nonsmooth functions, and (iii) Hessian-Lipschitz. For these settings, we analyze the oracle complexity of our algorithms to obtain appropriately defined notions of ϵ-stationary point or ϵ-approximate local minimizer. Notably, our complexities are independent of the dimension of the ambient Euclidean space and depend only on the intrinsic dimension of the manifold under consideration. We demonstrate the applicability of our algorithms by simulation results and real-world applications on black-box stiffness control for robotics and black-box attacks to neural networks.

Funding: J. Li and S. Ma acknowledge the support of the National Science Foundation (NSF) [Grants DMS-1953210, CCF-1934568, and CCF-2007797]. K. Balasubramanian acknowledges the support of the NSF [Grant DMS-2053918]. K. Balasubramanian and S. Ma acknowledge the support of the UC Davis CeDAR (Center for Data Science and Artificial Intelligence Research) Innovative Data Science Seed Funding Program.
Evaluating Count Prioritization Procedures for Improving Inventory Accuracy in Retail Stores
Authors: DeHoratius Nicole , Holzapfel Andreas , Kuhn Heinrich , Mersereau Adam J. , Sternbeck Michael
Published: September 2022

Problem definition: We compare several approaches for generating a prioritized list of items to be counted in a retail store, with the objective of detecting inventory record inaccuracy and unknown out of stocks. Academic/practical relevance: We consider both “rule-based” approaches, which sort items based on heuristic indices, and “model-based” approaches, which maintain probability distributions for the true inventory levels updated based on sales and replenishment observations. Methodology: Our study evaluates these approaches on multiple metrics using data from inventory audits we conducted at European home and personal care retailer dm-drogerie markt. Results: Our results support arguments for both rule-based and model-based approaches. We find that model-based approaches provide versatile visibility into inventory states and are useful for a broad range of objectives but that rule-based approaches are also effective as long as they are matched to the retailer’s goal. We find that “high-activity” rule-based policies, which favor items with high sales volumes, inventory levels, and past errors, are more effective at detecting inventory discrepancies. The best policies uncover over twice the discrepancies detected by random selection. A “low-activity” rule-based policy based on low recorded inventory levels, on the other hand, is more effective at detecting unknown out of stocks. The best policy detects over eight times the unknown out of stocks found by random selection. Managerial implications: Our findings provide immediate guidance to our retail partner on appropriate methods for detecting inventory record inaccuracy and unknown out of stocks. Our approach can be replicated at other retailers interested in customized optimization of their counting programs.

Funding: This work was supported by the Bavarian Ministry for Science and Arts [Grant BayIntAn_KUEI_2018_43] and the EHI Foundation and GS1 Germany [Prize for Best Collaboration Between Science and Practice in Retail Research (2019)]. A. J. Mersereau thanks the Sarah Graham Kenan Foundation for support.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.1119 .
Smoothed Variable Sample-Size Accelerated Proximal Methods for Nonsmooth Stochastic Convex Programs
Authors: Jalilzadeh Afrooz , Shanbhag Uday , Blanchet Jose , Glynn Peter W.
Published: September 2022

We consider the unconstrained minimization of the function F, where F = f + g, f is an expectation-valued nonsmooth convex or strongly convex function, and g is a closed, convex, and proper function. (I) Strongly convex f. When f is μ-strongly convex in x, traditional stochastic subgradient schemes ( SSG ) often display poor behavior, arising in part from noisy subgradients and diminishing steplengths. Instead, we apply a variable sample-size accelerated proximal scheme (VS-APM) on F, the Moreau envelope of F; we term such a scheme as ( mVS-APM ) and in contrast with ( SSG ) schemes, ( mVS-APM ) utilizes constant steplengths and increasingly exact gradients. We consider two settings. (a) Bounded domains. In this setting, ( mVS-APM ) displays linear convergence in inexact gradient steps, each of which requires utilizing an inner ( prox-SSG ) scheme. Specically, ( mVS-APM ) achieves an optimal oracle complexity in prox-SSG steps of [Formula: see text] with an iteration complexity of [Formula: see text] in inexact (outer) gradients of F to achieve an ϵ-accurate solution in mean-squared error, computed via an increasing number of inner (stochastic) subgradient steps; (b) Unbounded domains. In this regime, under an assumption of state-dependent bounds on subgradients, an unaccelerated variant ( mVS-APM ) is linearly convergent where increasingly exact gradients ∇xF(x) are approximated with increasing accuracy via ( SSG ) schemes. Notably, ( mVS-APM ) also displays an optimal oracle complexity of [Formula: see text]; (II) Convex f. When f is merely convex but smoothable, by suitable choices of the smoothing, steplength, and batch-size sequences, smoothed (VS-APM) (or sVS-APM) achieves an optimal oracle complexity of [Formula: see text] to obtain an ϵ-optimal solution. Our results can be specialized to two important cases: (a) Smooth f. Since smoothing is no longer required, we observe that (VS-APM) admits the optimal rate and oracle complexity, matching prior ndings; (b) Deterministic nonsmooth f. In the nonsmooth deterministic regime, (sVS-APM) reduces to a smoothed accelerated proximal method (s-APM) that is both asymptotically convergent and optimal in that it displays a complexity of [Formula: see text], matching the bound provided by Nesterov in 2005 for producing ϵ-optimal solutions. Finally, (sVS-APM) and (VS-APM) produce sequences that converge almost surely to a solution of the original problem.

Funding: The first and second authors would like to acknowledge support from NSF CMMI-1538605, DOE ARPA-E award DE-AR0001076, and the Gary and Sheila Bello Chair funds.
Analisis Strategi Pemasaran Usaha Catering Makanan Sehat untuk Orang Tanpa Gejala (OTG)
Authors: Sudarti Sudarti , Wardiana Rima
Published: September 2022

COVID-19 telah merubah tatanan kehidupan dalam waktu yang sangat singkat di dunia. Indonesia yang merupakan salah satu  negara dengan menduduki peringkat serius dalam terdampak merebaknya COVID-19 membuat pemerintah mengambil kebijakan pembatasan interaksi masyarakat. Pembatasan interaksi masyarakat ini bertujuan untuk memutus rantai penyebaran COVID-19 di level terendah.
Penelitian ini bertujuan 1) mengetahui faktor lingkungan internal yang berpengaruh terhadap strategi pemasaran usaha Catering makanan sehat untuk Orang Tanpa Gejala (OTG); 2) Mengetahui faktor lingkungan eksternal yang berpengaruh terhadap strategi usaha Catering makanan sehat untuk OTG, dan 3) Mengetahui sistem pemasaran yang sesuai untuk usaha Catering makanan sehat untuk OTG. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif dimana data diperoleh dengan cara wawancara, observasi, dan dokumentasi. Wawancara dilakukan di secara random dimana terdapat OTG pada kampung yang berada di wilayah Kota Yogyakarta..
Hasil lapangan digunakan untuk analisis SWOT yang terdiri dari tabel IFAS, tabel EFAS, matriks IE, dan matriks SWOT. Hasil penelitian ini menunjukkan faktor internal yang berpengaruh berupa Lokasi Strategis, Inovasi makanan up to date, Takaran gizi pada makanan sesuai kebutuhan, pemesanan harga produk makanan menyesuaikan kebutuhan, kurang promosi, keterbatasan armada pengiriman, Sumber Daya Manusia (SDM) dengan kemampuan terbatas. Faktor eksternal: jumlah pesaing sedikit, suplai tenaga kerja banyak, daya beli konsumen (OTG), suplai bahan pokok, respon masyarakat di sekitar baik, menu makanan mudah ditiru, faktor alergi makanan pada konsumen (OTG), harga bahan pokok yang tidak stabil.
Pengembangan Menu Seimbang Berbasis Pangan Lokal dengan Sajian Isi Piring Makanku sebagai Upaya Perbaikan Pola Konsumsi Ibu Hamil di Wilayah Terpencil Dataran Tinggi Pipikoro Kabupaten Sigi Propinsi Sulawesi Tengah
Authors: Nurjaya Nurjaya , Faisal Elvyrah , Aslinda Wery
Published: September 2022

Upaya perbaikan gizi masyarakat merupakan amanah pemerintah yang dapat dilakukan melalui perbaikan pola konsumsi makanan yang sesuai gizi seimbang dan perbaikan perilaku sadar gizi. Implementasi pedoman gizi seimbang dapat diterapkan pada ibu hamil melalui pengenalan menu seimbang berbasis pangan lokal dengan sajian isi piring makanku. Susunan menu seimbang yang dihasilkan dapat digunakan sebagai media KIE.
Tujuan penelitian ini adalah meningkatkan pola konsumsi makanan yang sesuai gizi seimbang melalui pengembangan menu seimbang berbasis pangan lokal dengan konsep sajian isi piring makanku. Jenis penelitian ini adalah mix method yakni penelitian yang menggabungkan 2 jenis penelitian yakni kualitatif dan kuantitatif. Informan adalah kader posyandu, tokoh masyarakat dan praktisi kuliner. Pengumpulan data dilakukan dengan indepth interview, Focus Group Discussion (FGD), observasi dan pengujian laboratorium.
Hasil penelitian ini adalah terciptanya 18 (delapan belas) set menu untuk 6 (enam) hari yang terdiri dari makan pagi, makan siang dan makan malam. Menu sehari yang disusun adalah menu dengan kandungan energi berkisar 2400 kalori dengan sajian mengikuti konsep isi piringku yakni porsi makanan pokok dan sayur sebesar 2/3 porsi dalam setengah piring dan porsi lauk pauk dan buah sebesar 1/3 porsi dalam setengah piring. Kegiatan penting yang ditempuh sebelum menyusun menu seimbang adalah eksplorasi bahan pangan lokal di wilayah penelitian meliputi identifikasi jenis bahan pangan lokal, akses perolehannya, teknik pengolahan dan analisis nilai gizi bahan pangan. Diperlukan eksplorasi yang lebih lengkap terutama dalam menggali kualitas gizi bahan pangan lokal di wilayah Pipikoro.