bluuebunny/crossref_metadata_2025 huggingface dataset:
Phosphorus-Induced Adaptation Mechanisms of Rye Grown on Post-Flotation Copper Tailings
Authors: Stępień Piotr , Gediga Krzysztof , Spiak Zofia
Published: August 2021

Although a considerable effort has been made over the last decades to develop cost-effective phytotechnologies as an alternative to conventional techniques for the management of contaminated lands, successful revegetation of the tailings still represents a major challenge. Here, we evaluate the potential of rye (Secale cereale L.) for growth and survival on the tailings after copper (Cu) ore processing. Four rye varieties were cultivated in a pot experiment on the post-flotation sediment with increasing phosphorus (P) doses (22, 44, 66, 88, and 110 mg·kg−1). The resistance of the studied rye genotypes to stress was assessed by observing the growth and development of plants, determining the dry mass accumulation, the Cu and P uptake and content, and a number of physiological parameters related mainly to P mobilisation. Exposure of tested rye varieties to high Cu concentrations in the tailings did not result in any significant plant mortality, with the intracellular Cu concentrations being below the critical toxic level. In contrast, the low availability of P due to alkaline properties of the tailings and the mechanisms involved in the mobilisation of sparingly soluble forms of this element (i.e., H+-ATPase-driven proton efflux in roots and organic acid exudation), were identified as main factor determining the level of tolerance. The efficiency of the photosynthetic activity was a key determinant for the P-mobilising capacity of rye. We further showed that rye varieties with more primitive genetic background might be potentially more suitable for growth on the post-flotation copper tailings. The results provide important and novel knowledge that will certainly support future works in developing strategies for successful revitalisation of degraded lands.
Artificial Plantation Responses to Periodic Submergence in Massive Dam and Reservoir Riparian Zones: Changes in Soil Properties and Bacterial Community Characteristics
Authors: Li Jiajia , Li Lijuan , Arif Muhammad , Ding Dongdong , Hu Xin , Zheng Jie , Yuan Zhongxun , Li Changxiao
Published: August 2021

Plant and microbiome interactions are necessary for plant nutrient acquisition. However, relatively little is known about the responses of roots, bulk, and rhizosphere soil microbial communities in different artificial vegetation types (woody and herbaceous) in riparian areas of massive dams and reservoirs. Therefore, this study aims to assess such responses at elevations of 165–170 m a.s.l. in the riparian zones of the Three Gorges Dam Reservoir, China. The samples were collected containing the rhizosphere soil, bulk soil, and roots of herbaceous and woody vegetation at different emergence stages in 2018. Then, all the samples were analyzed to quantify the soil properties, bacterial community characteristics, and their interaction in the early and late emergence phases. In different periods, the weight of dominant soil bacteria, including Proteobacteria, Acidobacteria, Actinobacteria, Chloroflexi, and Cyanobacteria, was higher, and their composition was different in the rhizosphere, bulk soil, and endophytes. Moreover, the soil co-occurrence networks indicated that the weight of soil physical properties was higher than chemical properties in the early emergence stage. In contrast, the weight of chemical properties was relatively higher in the late emergence stage. Furthermore, the richness and diversity of the bacterial community were mainly affected by soil organic matter. This study suggests that these herbaceous and woody vegetation are suitable for planting in reservoir areas affected by hydrology and human disturbance in light of soil nutrients and soil microbial communities, respectively. Additionally, these results provide valuable information to inoculate the soil with key microbiota members by applying fertilizers, potentially improving plant health and soil production.
Degraded Sericin Significantly Regulates Blood Glucose Levels and Improves Impaired Liver Function in T2D Rats by Reducing Oxidative Stress
Authors: Wang Heng-Da , Zhong Zhi-Hao , Weng Yu-Jie , Wei Zhen-Zhen , Zhang Yu-Qing
Published: August 2021

Sericin could be degraded well into low-molecular-weight sericin (SS) through a novel and environmentally friendly recycling process using an ultrasonically degumming method in Ca(OH)2 aqueous solution. The oral administration of the SS has an evidently hypoglycemic effect on STZ-induced T2D rats. At oral doses of 2.5 and 5% SS for four weeks, the fasting blood glucose decreased by over 60% compared with that in the untreated model group. Oral glucose tolerance and insulin tolerance were ameliorated by the peptide treatment. The serum insulin level was reduced by approximately 35%, the insulin resistance index was reduced by more than 66%. The 8-hydroxy-2 deoxyguanosine level showed a large reduction of 20%, and the total antioxidant activities significantly increased. Hematoxylin-eosin staining and fluorescent immunostaining sections showed that liver and pancreas damage was partly recovered in T2D rats. In summary, oral SS demonstrated evidently hypoglycemic effects mainly related to reducing oxidative stress in the damaged liver and pancreas of T2D rats. Therefore, these results have suggested that the degraded sericin has a potential use in SS-based healthy functional food or hypoglycemic drugs as a waste recovered from sericulture resources.
Chronic Pain in the Elderly: Mechanisms and Distinctive Features
Authors: Tinnirello Andrea , Mazzoleni Silvia , Santi Carola
Published: August 2021

Background: Chronic pain is a major issue affecting more than 50% of the older population and up to 80% of nursing homes residents. Research on pain in the elderly focuses mainly on the development of clinical tools to assess pain in patients with dementia and cognitive impairment or on the efficacy and tolerability of medications. In this review, we searched for evidence of specific pain mechanisms or modifications in pain signals processing either at the cellular level or in the central nervous system. Methods: Narrative review. Results: Investigation on pain sensitivity led to conflicting results, with some studies indicating a modest decrease in age-related pain sensitivity, while other researchers found a reduced pain threshold for pressure stimuli. Areas of the brain involved in pain perception and analgesia are susceptible to pathological changes such as gliosis and neuronal death and the effectiveness of descending pain inhibitory mechanisms, particularly their endogenous opioid component, also appears to deteriorate with advancing age. Hyperalgesia is more common at older age and recovery from peripheral nerve injury appears to be delayed. In addition, peripheral nociceptors may contribute minimally to pain sensation at either acute or chronic time points in aged populations. Conclusions: Elderly subjects appear to be more susceptible to prolonged pain development, and medications acting on peripheral sensitization are less efficient. Pathologic changes in the central nervous system are responsible for different pain processing and response to treatment. Specific guidelines focusing on specific pathophysiological changes in the elderly are needed to ensure adequate treatment of chronic pain conditions.
Diffusion Weighted Imaging and T2 Mapping Detect Inflammatory Response in the Renal Tissue during Ischemia Induced Acute Kidney Injury in Different Mouse Strains and Predict Renal Outcome
Authors: Greite Robert , Derlin Katja , Hartung Dagmar , Chen Rongjun , Meier Martin , Gutberlet Marcel , Hensen Bennet , Wacker Frank , Gueler Faikah , Hellms Susanne
Published: August 2021

To characterize ischemia reperfusion injury (IRI)-induced acute kidney injury (AKI) in C57BL/6 (B6) and CD1-mice by longitudinal functional MRI-measurement of edema formation (T2-mapping) and inflammation (diffusion weighted imaging (DWI)). IRI was induced with unilateral right renal pedicle clamping for 35min. 7T-MRI was performed 1 and 14 days after surgery. DWI (7 b-values) and multiecho TSE sequences (7 TE) were acquired. Parameters were quantified in relation to the contralateral kidney on day 1 (d1). Renal MCP-1 and IL-6-levels were measured by qPCR and serum-CXCL13 by ELISA. Immunohistochemistry for fibronectin and collagen-4 was performed. T2-increase on d1 was higher in the renal cortex (127 ± 5% vs. 94 ± 6%, p < 0.01) and the outer stripe of the outer medulla (141 ± 9% vs. 111 ± 9%, p < 0.05) in CD1, indicating tissue edema. Medullary diffusivity was more restricted in CD1 than B6 (d1: 73 ± 3% vs. 90 ± 2%, p < 0.01 and d14: 77 ± 5% vs. 98 ± 3%, p < 0.01). Renal MCP-1 and IL-6-expression as well as systemic CXCL13-release were pronounced in CD1 on d1 after IRI. Renal fibrosis was detected in CD1 on d14. T2-increase and ADC-reduction on d1 correlated with kidney volume loss on d14 (r = 0.7, p < 0.05; r = 0.6, p < 0.05) and could serve as predictive markers. T2-mapping and DWI evidenced higher susceptibility to ischemic AKI in CD1 compared to B6.
Treatment with PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia Lowers Plasma Levels of Platelet-Activating Factor and Its Precursors: A Combined Metabolomic and Lipidomic Approach
Authors: Di Minno Alessandro , Orsini Roberta Clara , Chiesa Mattia , Cavalca Viviana , Calcaterra Ilenia , Tripaldella Maria , Anesi Andrea , Fiorelli Susanna , Eligini Sonia , Colombo Gualtiero I. , Tremoli Elena , Porro Benedetta , Di Minno Matteo Nicola Dario
Published: August 2021

Introduction: Familial hypercholesterolemia (FH) is characterized by extremely high levels of circulating low-density lipoprotein cholesterol (LDL-C) and is caused by mutations of genes involved in LDL-C metabolism, including LDL receptor (LDLR), apolipoprotein B (APOB), or proprotein convertase subtilisin/Kexin type 9 (PCSK9). Accordingly, PCSK9 inhibitors (PCSK9i) are effective in LDL-C reduction. However, no data are available on the pleiotropic effect of PCSK9i. To this end, we performed an untargeted metabolomics approach to gather a global view on changes in metabolic pathways in patients receiving treatment with PCSK9i. Methods: Twenty-five FH patients starting treatment with PCSK-9i were evaluated by an untargeted metabolomics approach at baseline (before PCSK9i treatment) and after 12 weeks of treatment. Results: All the 25 FH subjects enrolled were on maximal tolerated lipid-lowering therapy prior to study entry. After a 12 week treatment with PCSK9i, we observed an expected significant reduction in LDL-cholesterol levels (from 201.0 ± 69.5 mg/dL to 103.0 ± 58.0 mg/dL, p < 0.001). The LDL-C target was achieved in 36% of patients. After peak validation and correction, after 12 weeks of PCSK9i treatment as compared to baseline, we observed increments in creatine (p-value = 0.041), indole (p-value = 0.045), and indoleacrylic acid (p-value= 0.045) concentrations. Conversely, significant decreases in choline (p-value = 0.045) and phosphatidylcholine (p-value < 0.01) together with a reduction in platelet activating factor (p-value = 0.041) were observed. Conclusions: Taking advantage of untargeted metabolomics, we first provided evidence of concomitant reductions in inflammation and platelet activation metabolites in FH patients receiving a 12 week treatment with PCSK9i.
Adhesion of Platelets to Colon Cancer Cells Is Necessary to Promote Tumor Development in Xenograft, Genetic and Inflammation Models
Authors: Cariello Marica , Piccinin Elena , Zerlotin Roberta , Piglionica Marilidia , Peres Claudia , Divella Chiara , Signorile Anna , Villani Gaetano , Ingravallo Giuseppe , Sabbà Carlo , Moschetta Antonio
Published: August 2021

Platelets represent the linkage between tissue damage and inflammatory response with a putative role in tumorigenesis. Given the importance of the microenvironment in colon cancer development, we elucidated the eventual role of platelets-cancer cells crosstalk in in vivo colon cancer models. To evaluate the involvement of platelets in intestinal tumorigenesis, we first analyzed if the ablation of β-integrin P-selectin that drives platelets-cell adhesion, would contribute to platelets-colon cancer cell interaction and drive cancer progression. In a xenograft tumor model, we observed that when tumors are inoculated with platelets, the ablation of P-selectin significantly reduced tumor growth compared to control platelets. Furthermore, in genetic models, as well as in chronic colitis-associated colorectal carcinogenesis, P-selectin ablated mice displayed a significant reduction in tumor number and size compared to control mice. Taken together, our data highlights the importance of platelets in the tumor microenvironment for intestinal tumorigenesis. These results support the hypothesis that a strategy aimed to inhibit platelets adhesion to tumor cells are able to block tumor growth and could represent a novel therapeutic approach to colon cancer treatment.
Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model
Authors: Kim Michele M. , Verginadis Ioannis I. , Goia Denisa , Haertter Allison , Shoniyozov Khayrullo , Zou Wei , Maity Amit , Busch Theresa M. , Metz James M. , Cengel Keith A. , Dong Lei , Koumenis Costas , Diffenderfer Eric S.
Published: August 2021

Ultra-high dose rate FLASH proton radiotherapy (F-PRT) has been shown to reduce normal tissue toxicity compared to standard dose rate proton radiotherapy (S-PRT) in experiments using the entrance portion of the proton depth dose profile, while proton therapy uses a spread-out Bragg peak (SOBP) with unknown effects on FLASH toxicity sparing. To investigate, the biological effects of F-PRT using an SOBP and the entrance region were compared to S-PRT in mouse intestine. In this study, 8–10-week-old C57BL/6J mice underwent 15 Gy (absorbed dose) whole abdomen irradiation in four groups: (1) SOBP F-PRT, (2) SOBP S-PRT, (3) entrance F-PRT, and (4) entrance S-PRT. Mice were injected with EdU 3.5 days after irradiation, and jejunum segments were harvested and preserved. EdU-positive proliferating cells and regenerated intestinal crypts were quantified. The SOBP had a modulation (width) of 2.5 cm from the proximal to distal 90%. Dose rates with a SOBP for F-PRT or S-PRT were 108.2 ± 8.3 Gy/s or 0.82 ± 0.14 Gy/s, respectively. In the entrance region, dose rates were 107.1 ± 15.2 Gy/s and 0.83 ± 0.19 Gy/s, respectively. Both entrance and SOBP F-PRT preserved a significantly higher number of EdU + /crypt cells and percentage of regenerated crypts compared to S-PRT. Moreover, tumor growth studies showed no difference between SOBP and entrance for either of the treatment modalities.
Surgical Techniques and Outcomes of Colorectal Anastomosis after Left Hemicolectomy with Low Anterior Rectal Resection for Advanced Ovarian Cancer
Authors: Nishikimi Kyoko , Tate Shinichi , Matsuoka Ayumu , Otsuka Satoyo , Shozu Makio
Published: August 2021

Extended colon resection is often performed in advanced ovarian cancer. Restoring intestinal continuity and avoiding stoma creation improve patients’ quality of life postoperatively. We tried to minimize the number of anastomoses, restore intestinal continuity, and avoid stoma creation for 295 patients with stage III/IV ovarian cancer who underwent low anterior rectal resection (LAR) with or without colon resection during cytoreductive surgery. When the remaining colon could not reach the rectal stump after left hemicolectomy with LAR, we used the following techniques for tension-free anastomosis: right colonic transposition, retro-ileal anastomosis through an ileal mesenteric defect, or an additional colic artery division. Rates of stoma creation and rectal anastomotic were 3% (9/295) and 6.6% (19/286), respectively. Among 21 patients in whom the remaining colon did not reach the rectal stump after left hemicolectomy with LAR, 20 underwent tension-free anastomosis, including eight, six, and six patients undergoing right colonic transposition, retro-ileal anastomosis through an ileal mesenteric defect, and an additional colic artery division, respectively. Colorectal anastomosis is feasible for patients with extended colonic resection. Low anastomotic leakage and stoma rates can be achieved with careful attention to colonic mobilization and tension-free anastomosis.
Application of Mineral Compounds for a High-Voltage Portable Grounding System: An Experimental Study
Authors: Ahmad Rizwan , Kassas Mahmoud , Ahmed Chokri B. , Khan Faisal , Khan Sikandar , Jamal Arshad , Ullah Irshad
Published: August 2021

Electrical grounding is an indispensable part of the power system network. The grounding system is mainly affected by grounding resistance and the nature of the soil. High ground resistance produces the phenomenon of soil ionization, surface arching, and back flashover. A conventional grounding system requires the deep digging of electrodes, thus creating maintenance difficulties. This research work focuses on the safe operation of an electric power system from external and internal impulses arising due to lightning strikes or short circuits. The study proposes an application of mineral samples as grounding materials, and bentonite is used as backfilling material in portable grounding systems. A detailed experimental analysis was conducted under controlled conditions to evaluate the performance of selected materials in high-resistance soil. The problem of a deeply driven electrode is addressed by designing the portable grounding system. The study results demonstrate that the proposed portable grounding system could be installed in troubled environments such as forests, deserts, and rocky terrains. To measure the breakdown voltages of the proposed samples, X-ray Diffraction (XRD) analysis and other laboratory tests were conducted. The electric field intensities are extracted through Finite Element Analysis (FEA). The experimental and simulation findings show the expected performance of mineral samples under various operating conditions. The findings of this study can guide the practitioners for safe and efficient operations of portable electrical grounding systems.
Monitoring the Geometry Morphology of Complex Hydraulic Fracture Network by Using a Multiobjective Inversion Algorithm Based on Decomposition
Authors: Zhang Liming , Xue Lili , Cui Chenyu , Qi Ji , Sun Jijia , Zhou Xingyu , Dai Qinyang , Zhang Kai
Published: August 2021

The fracturing technique is widely used in many fields. Fracture has a greater impact on the movement of fluids in formations. Knowing information about a fracture is key to judging its effect, but detailed information about complex fracture networks is difficult to obtain. In this paper, we propose a new method to describe the shape of a complex fracture network. This method is based on microseismic results and uses the L-system to establish a method for characterizing a complex fracture network. The method also combines with decomposition to construct a new method called the multiobjective fracture network inversion algorithm based on decomposition (MOFNIAD). The coverage of microseismic monitoring results and the degree of fitting of production data are the two objective functions of the inversion fracture network. The multiobjective fracture network inversion algorithm can be optimized to obtain multiple optimal solutions that meet different target weights. Therefore, this paper established a multischeme decision method that approached the ideal solution, sorting technology and AHP to provide theoretical guidance for finding a more ideal fracture network. According to the error of microseismic monitoring results, we established two cases of fracture to verify the proposed method. Judging from the results of the examples, the fracture network finally obtained was similar to actual fractures.
Design and Implementation of an Intelligent ANFIS Controller on a Raspberry Pi Nano-Computer for Photovoltaic Pumping Intended for Drip Irrigation
Authors: Bellahirich Siwar , Mezghani Dhafer , Mami Abdelkader
Published: August 2021

For several decades, many countries have favored irrigation as a means of regulating, diversifying, and increasing agricultural production to meet the growing domestic demand for food, and even to generate exportable surpluses. As with most Mediterranean countries, Tunisia has inherited a long tradition in irrigation; thus, the management of the scarcity of water resources poses a very important challenge that is gradually increasing due to the effects of climate change undergone by the region and confronting the agricultural sector. Aiming at a new model of sustainable development, ensuring the optimization of water resources management, as well as the protection of natural resources and the environment, this work proposed the modern design of a photovoltaic pumping chain dedicated for drip irrigation, which is controlled using an intelligent neuron-fuzzy controller with an ANFIS architecture and implemented on a Raspberry Pi platform. Thanks to this design, the efficiency of the pumping chain increased exponentially to a value of approximately 95%, achieving water pumping optimization while exploiting renewable energy resources, thus guaranteeing the longevity of water resources, as well as the continuity of diversified agricultural production.
Assessing the Cooling Effect of Four Urban Parks of Different Sizes in a Temperate Continental Climate Zone: Wroclaw (Poland)
Authors: Blachowski Jan , Hajnrych Monika
Published: August 2021

Urban parks have been known to form park cooling islands (PCI), which can effectively alleviate the effect of urban heat islands (UHI) in cities. This paper presents results obtained for four different size parks in the city of Wroclaw, which is located in a temperate continental climate. The number of publications for urban areas located in this type of climate and cities is low compared to sites in hot and humid areas. Land surface temperature (LST) maps were developed from Landsat 8 Thermal Infrared Sensor (TIRS) data acquired during three hottest weather periods between 2017 and 2019. Metrics and spatial statistics characterising the four parks selected for the analysis based on their size were calculated. These included: perimeter, area, landscape shape index (LSI) and PLC (forest area) park metrics, and Park Cooling Area (PCA), Park Cooling Efficiency (PCE), Park Cooling Gradient (PCG), Park Cooling Island (PCI) and Extended Park Cooling Island (PCIe) spatial indexes. The averaged PCIe values ranged from 2.0 to 3.6 °C, PCI from 1.9 to 3.6 °C, PCG from 0.7 to 2.2 °C, PCE from 5.3 to 11.5, and PCA from 78.8 to 691.8 ha depending on the park. The cooling distance varied from 110 m to 925 m depending on park size, forest area and land use type in the park’s vicinity. The study provides new insight into urban park cooling effects in a medium sized city located in a temperate continental climate, and the role of parks in regulation of urban temperature to mitigate the UHI effect.
Different Gene Expression Patterns of Hexose Transporter Genes Modulate Fermentation Performance of Four Saccharomyces cerevisiae Strains
Authors: Nadai Chiara , Crosato Giulia , Giacomini Alessio , Corich Viviana
Published: August 2021

In Saccharomyces cerevisiae, the fermentation rate and the ability to complete the sugar transformation process depend on the glucose and fructose transporter set-up. Hexose transport mainly occurs via facilitated diffusion carriers and these are encoded by the HXT gene family and GAL2. In addition, FSY1, coding a fructose/H+ symporter, was identified in some wine strains. This little-known transporter could be relevant in the last part of the fermentation process when fructose is the most abundant sugar. In this work, we investigated the gene expression of the hexose transporters during late fermentation phase, by means of qPCR. Four S. cerevisiae strains (P301.9, R31.3, R008, isolated from vineyard, and the commercial EC1118) were considered and the transporter gene expression levels were determined to evaluate how the strain gene expression pattern modulated the late fermentation process. The very low global gene expression and the poor fermentation performance of R008 suggested that the overall expression level is a determinant to obtain the total sugar consumption. Each strain showed a specific gene expression profile that was strongly variable. This led to rethinking the importance of the HXT3 gene that was previously considered to play a major role in sugar transport. In vineyard strains, other transporter genes, such as HXT6/7, HXT8, and FSY1, showed higher expression levels, and the resulting gene expression patterns properly supported the late fermentation process.
Psychosocial Well-Being of Patients with Kidney Failure Receiving Haemodialysis during a Pandemic: A Survey
Authors: McKeaveney Clare , Noble Helen , Carswell Claire , Johnston William , Reid Joanne
Published: August 2021

Background: Living with kidney failure and undergoing hospital haemodialysis (HD) is associated with a high prevalence of mental health problems and poor quality of life. However, the COVID-19 pandemic has brought additional challenges for this patient population. Objectives: To understand the impact on mental health and well-being during the COVID-19 pandemic in people receiving HD. Methods: An online survey using a cross-sectional study design. Two validated assessment tools (General Health Questionnaire-12 (GHQ-12); Personal Wellbeing Index (PWI)), binary, Likert and free-text qualitative questions were included. Individuals with kidney failure receiving HD, over 18 years of age, were recruited online between July and August 2020. Results: Forty-four participants were recruited. Approximately, 54% of respondents were tested for COVID-19; however, no positive results were reported by patients or associated family members. Scores of GHQ-12 and PWI were compared with those from previous studies. Mental health distress was higher in prevalence (68.2%) and severity (M = 18.3) in this study when compared to that of the general population in Northern Ireland during COVID-19 (April 2020). In addition, well-being (M = 37.16, SD = 18.19) was poorer when compared to that of a pre-COVID-19 dialysis patient population. Conclusion: During the current pandemic, individuals receiving hospital HD have heightened mental health distress, and their well-being is impacted negatively. This study reinforces the need to provide appropriate psychosocial care as well as supportive interventions for mental distress to patients with kidney failure during and after the COVID-19 pandemic.
The First 1000 Days: Impact of Prenatal Tobacco Smoke Exposure on Hospitalization Due to Preschool Wheezing
Authors: Collet Cyrielle , Fayon Michael , Francis Florence , Galode François , Bui Stephanie , Debelleix Stephane
Published: August 2021

Preschool wheezing and related hospitalization rates are increasing. Prenatal tobacco smoke exposure (PTSE) increases the risk of wheezing, yet >20% of French women smoke during pregnancy. In this observational retrospective monocentric study, we assessed the link between PTSE and hospital admissions. We included infants <2 years of age admitted for acute wheezing. A phone interview with mothers was completed by electronic records. The primary endpoint was the ratio of cumulative duration of the hospitalization stays (days)/age (months). 129 children were included (36.4% exposed to PTSE vs. 63.6% unexposed). There was a significant difference in the duration of hospitalization/age: 0.9 days/month (exposed) vs. 0.58 days/month (unexposed) (p = 0.008). Smoking one cigarette/day during pregnancy was associated with an increase in hospitalization duration of 0.055 days/month (r = 0.238, p = 0.006). In the multi-variable analysis, this positive association persisted (β = 0.04, p = 0.04; standardized β = 0.27, p = 0.03). There was a trend towards a dose-effect relationship between PTSE and other important parameters associated with hospital admissions. We have demonstrated a dose-effect relationship, without a threshold effect, between PTSE and duration of hospitalization for wheezing in non-premature infants during the first 2 years of life. Prevention campaigns for future mothers should be enforced.
Electronic Device Use before Bedtime and Sleep Quality among University Students
Authors: Pham Hue Thi , Chuang Hsiao-Ling , Kuo Ching-Pyng , Yeh Tzu-Pei , Liao Wen-Chun
Published: August 2021

Using electronic devices before bedtime impacts sleep quality and has become a major public health issue. This study aims to investigate the associations between electronic devices (EDs) use before bedtime and sleep quality in Vietnamese university students. A total of 369 university students from three departments were recruited. Participants completed self-report surveys, including demographic characteristics, lifestyle, ED-use behaviors, the Pittsburgh Sleep Quality Index, and the Center for Epidemiologic Studies Depression Scale. A total of 48.8% of the students experienced poor sleep quality, and 98.1% reported using at least one type of ED every day within two hours before bedtime. Smartphones are the most used devices (92.3%). ED usage within two hours before bedtime (p = 0.031), lack of exercise (p = 0.006), alcohol consumption (p = 0.025), and coffee intake after 4 pm (p = 0.018) were associated with poor sleep quality. ED use near bedtime for a duration longer than 30 min (p = 0.001) and depression (p < 0.001) were associated with poorer sleep quality among university students. ED use near bedtime more than 30 min was significantly associated with poorer sleep quality after adjusting depression status, exercise, and caffeine/alcohol intake in the latter part of the day. This study emphasizes the importance of adequate sleep and restriction of ED use near bedtime, which are necessary for better sleep in university students.
Quantification of the Psychoacoustic Effect of Noise from Small Unmanned Aerial Vehicles
Authors: Hui C. T. Justine , Kingan Michael J. , Hioka Yusuke , Schmid Gian , Dodd George , Dirks Kim N. , Edlin Shaun , Mascarenhas Sean , Shim Young-Min
Published: August 2021

This paper presents the results of a study evaluating the human perception of the noise produced by four different small quadcopter unmanned aerial vehicles (UAVs). This study utilised measurements and recordings of the noise produced by the quadcopter UAVs in hover and in constant-speed flight at a fixed altitude. Measurements made using a ½″ microphone were used to calculate a range of different noise metrics for each noise event. Noise recordings were also made using a spherical microphone array (an Eigenmike system). The recordings were reproduced using a 3D sound reproduction system installed in a large anechoic chamber located at The University of Auckland. Thirty-seven participants were subjected to the recordings and asked to rate their levels of annoyance in response to the noise, and asked to perform a simple cognitive task in order to assess the level of distraction caused by the noise. This study discusses the noise levels measured during the test and how the various noise metrics relate to the annoyance ratings. It was found that annoyance strongly correlates with the sound pressure level and loudness metrics, and that there is a very strong correlation between the annoyance caused by a UAV in hover and in flyby at the same height. While some significant differences between the distraction caused by the UAV noise for different cases were observed in the cognitive distraction test, the results were inconclusive. This was likely due to a ceiling effect observed in the participants’ test scores.
The Stressor in Adolescence of Menstruation: Coping Strategies, Emotional Stress & Impacts on School Absences among Young Women in Nepal
Authors: Yilmaz Siobhan K. , Bohara Alok K. , Thapa Swati
Published: August 2021

Throughout the developing world, girls face hardships surrounding menstruation, often resulting in poor emotional wellbeing and missing school. Providing ways to keep girls in school will increase their educational and earning potentials, which will ultimately trickle down to improving the economic standing of nations in the next generation. Informed by the Transactional Model of Stress and Coping, this work evaluates the roles that cultural and school environments play in appraisals of menstruation as a major life stressor for adolescent females and the impacts of emotional stress on missing school. Using primary survey data from schools in Nepal, robust results are found to support the theoretical framework based on conditional mixed-process (CMP) estimation with fixed effects, utilizing multiple index building techniques. Strong cultural norms during menstruation appear to increase the probability of girls self-reporting emotional stress, while the presence of hygiene supporting infrastructure at schools reduces this outcome. Furthermore, there is strong support for the finding that the presence of emotional stress during menstruation increases the likelihood of not only missing school but also for an extended period of time. Our findings motivate increasing government policies to provide stronger hygiene infrastructure in schools to improve successful coping skills and attendance rates.
The Integration of Linguistic and Geospatial Features Using Global Context Embedding for Automated Text Geocoding
Authors: Yan Zheren , Yang Can , Hu Lei , Zhao Jing , Jiang Liangcun , Gong Jianya
Published: August 2021

Geocoding is an essential procedure in geographical information retrieval to associate place names with coordinates. Due to the inherent ambiguity of place names in natural language and the scarcity of place names in textual data, it is widely recognized that geocoding is challenging. Recent advances in deep learning have promoted the use of the neural network to improve the performance of geocoding. However, most of the existing approaches consider only the local context, e.g., neighboring words in a sentence, as opposed to the global context, e.g., the topic of the document. Lack of global information may have a severe impact on the robustness of the model. To fill the research gap, this paper proposes a novel global context embedding approach to generate linguistic and geospatial features through topic embedding and location embedding, respectively. A deep neural network called LGGeoCoder, which integrates local and global features, is developed to solve the geocoding as a classification problem. The experiments on a Wikipedia place name dataset demonstrate that LGGeoCoder achieves competitive performance compared with state-of-the-art models. Furthermore, the effect of introducing global linguistic and geospatial features in geocoding to alleviate the ambiguity and scarcity problem is discussed.
Familial Melanoma and Susceptibility Genes: A Review of the Most Common Clinical and Dermoscopic Phenotypic Aspect, Associated Malignancies and Practical Tips for Management
Authors: Zocchi Lamberto , Lontano Alberto , Merli Martina , Dika Emi , Nagore Eduardo , Quaglino Pietro , Puig Susana , Ribero Simone
Published: August 2021

A family history of melanoma greatly increases the risk of developing cutaneous melanoma, a highly aggressive skin cancer whose incidence has been steadily increasing worldwide. Familial melanomas account for about 10% of all malignant melanomas and display an inheritance pattern consistent with the presence of pathogenic germline mutations, among which those involving CDKN2A are the best characterized. In recent years, a growing number of genes, such as MC1R, MITF, CDK4, POT1, TERT, ACD, TERF2IP, and BAP1, have been implicated in familial melanoma. The fact that individuals harboring these germline mutations along with their close blood relatives have a higher risk of developing multiple primary melanomas as well as other internal organ malignancies, especially pancreatic cancer, makes cascade genetic testing and surveillance of these families of the utmost importance. Unfortunately, due to a polygenic inheritance mechanism involving multiple low-risk alleles, genetic modifiers, and environmental factors, it is still very difficult to predict the presence of these mutations. It is, however, known that germline mutation carriers can sometimes develop specific clinical traits, such as high atypical nevus counts and specific dermoscopic features, which could theoretically help clinicians predict the presence of these mutations in prone families. In this review, we provide a comprehensive overview of the high- and intermediate-penetrance genes primarily linked to familial melanoma, highlighting their most frequently associated non-cutaneous malignancies and clinical/dermoscopic phenotypes.
Association between Tooth Loss and Alzheimer’s Disease in a Nested Case–Control Study Based on a National Health Screening Cohort
Authors: Kim Ji Hee , Oh Jae Keun , Wee Jee Hye , Kim Yoo Hwan , Byun Soo-Hwan , Choi Hyo Geun
Published: August 2021

Background: Reports on the possible risks for Alzheimer’s disease (AD) have included tooth loss as a potential risk factor. However, there are few studies addressing the association between tooth loss and AD in a large sample of participants. Accordingly, the objective of the current study was to explore the association of tooth loss with the development of AD in Korean adults. Methods: This nested case–control study, which is an analysis utilizing the data of the Korean National Health Insurance Service Health Screening Cohort study, randomly selected AD and control participants among Korean residents aged ≥60 years. The association between the number of missing teeth and AD occurrence was examined using a logistic regression model. Participants’ lifestyle factors (smoking and alcohol consumption) and various medical conditions and comorbidities were included as covariates. Results: The mean number of missing teeth was 2.94 in the AD group and 2.59 in the control group. After adjusting for covariates, tooth loss was significantly associated with AD, with an odds ratio (OR) (per 16 missing teeth) of 1.15 (95% confidence interval (CI) = 1.07–1.23, p < 0.001). Conclusions: Tooth loss remained consistently significantly associated with an increased risk of AD for both upper and lower tooth loss. A higher number of missing teeth was related to a higher probability of AD occurrence in an elderly Korean population. Efforts to manage tooth loss could be a possible approach to prevent AD.
Comparing the Accuracy of Visual and Computerized Onset Detection Methods on Simulated Electromyography Signals with Varying Signal-to-Noise Ratios
Authors: Kowalski Erik , Catelli Danilo S. , Lamontagne Mario
Published: August 2021

Electromyography (EMG) onsets determined by computerized detection methods have been compared against the onsets selected by experts through visual inspection. However, with this type of approach, the true onset remains unknown, making it impossible to determine if computerized detection methods are better than visual detection (VD) as they can only be as good as what the experts select. The use of simulated signals allows for all aspects of the signal to be precisely controlled, including the onset and the signal-to-noise ratio (SNR). This study compared three onset detection methods: approximated generalized likelihood ratio, double threshold (DT), and VD determined by eight trained individuals. The selected onset was compared against the true onset in simulated signals which varied in the SNR from 5 to 40 dB. For signals with 5 dB SNR, the VD method was significantly better, but for SNRs of 20 dB or greater, no differences existed between the VD and DT methods. The DT method is recommended as it can improve objectivity and reduce time of analysis when determining EMG onsets. Even for the best-quality signals (SNR of 40 dB), all the detection methods were off by 15–30 ms from the true onset and became progressively more inaccurate as the SNR decreased. Therefore, although all the detection methods provided similar results, they can be off by 50–80 ms from the true onset as the SNR decreases to 10 dB. Caution must be used when interpreting EMG onsets, especially on signals where the SNR is low or not reported at all.
Variation and Episodes of Near-Inertial Internal Waves on the Continental Slope of the Southeastern East China Sea
Authors: Yang Bing , Hu Po , Hou Yijun
Published: August 2021

Based on in situ observations, six episodes of near-inertial internal waves (NIWs) were detected on the East China Sea (ECS) continental slope, and the mechanisms and characteristics of them were examined. The generation mechanisms of the observed NIWs included typhoon, wind burst, lateral propagation, and energy transfer from low-frequency flow. The depth-integrated near-inertial kinetic energy (NIKE) showed no significant seasonal variation, and the annual mean NIKE and near-inertial currents were 400 J/m2 and 3.50 cm/s, respectively. Downward propagation of NIKE was evident in the small wavenumber band according to the rotary vertical wavenumber spectra. The NIKE was subsurface-intensified, and the near-inertial vertical shear reached 0.01 s−1. The vertical phase speeds of the NIWs ranged from 5 to 19 m/h. The frequencies of the NIWs were mostly red-shifted, however, blue-shift also existed. One episode had both blue- and red-shifted frequencies vertically, and had both upward and downward propagating vertical phase speeds. The e-folding times of the observed NIWs ranged from 4 to 11 days, which were influenced by successive wind bursts and background vorticity. On the left-hand side of Kuroshio, the background vorticity is usually positive; however, the NIWs were almost red-shifted, which resulted from the Doppler shift of the Kuroshio.
Divining the Future: Making Sense of Ecological Uncertainty in Turkana, Northern Kenya
Authors: Derbyshire Samuel F. , Nami Joseph Ekidor , Akall Gregory , Lowasa Lucas
Published: August 2021

This article draws on long-term ethnographic fieldwork to examine some recent livelihood transformations that have taken place in the Turkana region of northern Kenya. In doing so, it discusses some of the ways in which uncertainty and variability have been managed in Turkana to date and considers what this means in relation to a future that promises continued radical economic and ecological change. Discussing a selection of examples, we argue that understandings of contemporary transformative processes are enhanced through attention to the ways in which various forms of knowledge have been constituted and implemented over the long term. We suggest that ongoing transformations within livelihood practices, inter-livelihood relationships and corresponding patterns of mobility might best be understood as manifestations of a long-standing capacity for successfully managing the very uncertainty that characterises daily life.
Investigation on Microstructure and Properties of Duplex Stainless Steel Welds by Underwater Laser Welding with Different Shielding Gas
Authors: Wang Kai , Shao Changlei , Jiao Xiangdong , Zhu Jialei , Cai Zhihai , Li Congwei
Published: August 2021

Taking S32101 duplex stainless steel as the research object, underwater laser wire filling welding technology was used for U-groove filling welding. The influence of different shielding gas compositions on the ferrite content, microstructure, mechanical properties and pitting corrosion resistance was studied by simulating a water depth of 15 m in the hyperbaric chamber. The results show that, under the same process parameters, the size and proportion of austenite in the weld when using pure nitrogen as the shielding gas are larger than those protected by other shielding gases. In a mixed shielding gas, the increase in nitrogen content has little effect on the strength and toughness of the weld. Regardless of the shielding gas used, the base metal was the weakest part of the weld. At the same time, intermetallic inclusions have an adverse effect on the impact toughness of the weld. The pitting corrosion resistance of the welds depends on the Cr2N content in the heat-affected zone. The precipitation and enrichment of Cr2N causes local chromium deficiency, which is the main factor for the weak pitting corrosion ability of the heat-affected zone. Pure nitrogen protection has a better corrosion resistance than other gas protection.
Enhancing the Oxidation Resistance of Al2O3-SiC-C Castables via Introducing Micronized Andalusite
Authors: Wang Xiaoyu , Wang Saixin , Mu Yuandong , Zhao Ruijie , Wang Qingfeng , Parr Chris , Ye Guotian
Published: August 2021

Additions of andalusite aggregates (19 wt%) were shown in previous literature to enhance the antioxidation of Al2O3-SiC-C (ASC) castables. This work aims to investigate whether micronized andalusite has a greater influence on antioxidation improvement than andalusite aggregates. Various low contents (5 wt% and below) of micronized andalusite (≤5 μm) were introduced as a substitute for brown fused alumina in the matrix of ASC castables. The antioxidation of castable specimens was estimated by the oxidized area ratio on the fracture surface after a thermal shock test. The microstructure and phases of micronized andalusite and the castable specimens were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. The results suggest that the antioxidation effects of ASC castables with a low addition of micronized andalusite are effectively enhanced. The heat-induced transformation of andalusite produces SiO2-rich glass, favoring the sintering of the castable matrix and impeding oxygen diffusion into the castable’s interior. Therefore, the castable antioxidation is enhanced without deteriorating the hot modulus of rupture.
Logistic Biplot by Conjugate Gradient Algorithms and Iterated SVD
Authors: Babativa-Márquez Jose Giovany , Vicente-Villardón José Luis
Published: August 2021

Multivariate binary data are increasingly frequent in practice. Although some adaptations of principal component analysis are used to reduce dimensionality for this kind of data, none of them provide a simultaneous representation of rows and columns (biplot). Recently, a technique named logistic biplot (LB) has been developed to represent the rows and columns of a binary data matrix simultaneously, even though the algorithm used to fit the parameters is too computationally demanding to be useful in the presence of sparsity or when the matrix is large. We propose the fitting of an LB model using nonlinear conjugate gradient (CG) or majorization–minimization (MM) algorithms, and a cross-validation procedure is introduced to select the hyperparameter that represents the number of dimensions in the model. A Monte Carlo study that considers scenarios with several sparsity levels and different dimensions of the binary data set shows that the procedure based on cross-validation is successful in the selection of the model for all algorithms studied. The comparison of the running times shows that the CG algorithm is more efficient in the presence of sparsity and when the matrix is not very large, while the performance of the MM algorithm is better when the binary matrix is balanced or large. As a complement to the proposed methods and to give practical support, a package has been written in the R language called BiplotML. To complete the study, real binary data on gene expression methylation are used to illustrate the proposed methods.