bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence Of Tea Types In Making Kombucha On The Taste And Preference Of Hoteliers In Batam
Authors: Rizhon Rizhon , Maldin Siska Amelia
Published: November 2023

Kombucha is a popular drink with its benefits for human health. This tea-based drink is very famous in the world of tourism for its sour and refreshing taste. Kombucha is generally made using green tea or black tea. However, many types of tea can be used, such as white tea, oolong tea, and so on. Usually, kombucha is made using tea, sugar, and water, then given bacteria and fungi to ferment for around 7 – 15 days. This research aims to see how the use of tea as a basic ingredient affects the taste and preferences of hoteliers in Batam, where 15 panelists carried out organoleptic tests on 8 samples of kombucha that have been prepared, where the only differentiating variable is the type of tea used, the results found that kombucha that is made from green tea is most liked by the panelists, meanwhile, the kombucha that is made from black tea is least liked.
Review Of The Punishment Of Substitute Money And Its Consequences In The Criminal Act Of Corruption (Study Of Decision Number 51 / Pid. Sus-Tpk/2020/Pn. Smg)
Authors: Mukayatsyah Romli , Surbakti Natangsa , Iksan Muchamad
Published: November 2023

Payment of substitute money is an additional crime imposed by the panel of judges to recover state financial losses, as in Decision Number 51/Pid.Sus-TPK/2020/PN. Smg. The verdict is interesting to examine, what is the result of the panel of judges imposing additional penalties in the payment of substitute money in accordance with the purpose of the law, as well as how the view according to Islam. The study aims to analyze the consequences of the panel of judges imposing an additional criminal judgment on the payment of substitute money in Decision Number 51/Pid.Sus- TPK/2020/PN. Smg and his views according to Islam. The research is normative legal research, with a statutory approach and a conceptual approach, legal materials in the form of primary, secondary, and non-legal, the object of research is Decision Number 51 / Pid.Sus-TPK / 2020 / PN. Smg. Techniques for collecting legal materials with literature studies, with deductive analysis methods. The results of the study, as a result of which the judge's consideration did not clearly outline the calculation of state money used by the convict, imperfect defects, and non-achievement of legal objectives. Additional penalties for payment of substitute money according to Islam can be imposed on the convict because the property of Allah SWT is a mandate that must be accounted for its use
The Effect Of E-Wom, Price And Service Quality On Purchasing Decisions Mediated By Marketing Strategy (Thrift Shop Empirical Study On Tiktok Social Media)
Authors: Marcellino Yeremia , Pardede Ratlan
Published: November 2023

This study aims to determine the effect of EWOM, Price, and Service Quality on purchasing decisions mediated by marketing strategy (thrift shop empirical study on Tik Tok Social Media). The research data was obtained from distributing questionnaires via the Google form by providing twenty questions. Samples were taken using a purposive sampling technique with a total of 220 respondents. This research was distributed in the Banten area, namely Tangerang Regency, Tangerang City and South Tangerang by looking at the high level of internet usage. This study uses quantitative analysis techniques and is processed using AMOS. The purpose of this study is to see how EWOM, price and service quality can influence purchasing decisions. The results of this study indicate that EWOM and service quality have a positive and significant influence on purchasing decisions. However, Price do not have a positive and significant influence on purchasing decisions.
PLANTES MÉDICINALES UTILISÉES EN MÉDECINE TRADITIONNELLE POUR LE CONTRÔLE DES MALADIES FONGIQUES DANS LE DÉPARTEMENT DE KORHOGO (CÔTE D’IVOIRE)
Authors: SORO Dramane , SANOGO Yacouba , OUATTARA Gnelé Maïmouna Lavie
Published: November 2023

Contexte : Les populations rurales qui représentent une couche sociale vulnérable utilisent les plantes médicinales contre les affections fongiques pour leur soin de santé primaire. L’objectif de cette étude était de faire un inventaire floristique des plantes utilisées en médecine traditionnelles pour soigner les maladies fongiques par les herboristes et des tradipraticiens du Département de Korhogo. Méthodologie : Enquête ethnobotanique a été réalisée auprès des herboristes et des tradipraticiens du Département de Korhogo pendant la période du 20 Août au 17 Octobre 2019. Résultats : Quarante espèces végétales réparties en 39 genres et 22 familles ont été enregistrées. Les familles ayant les plus grandes diversités spécifiques étaient les Fabaceae (27,27 %), Combretaceae (22, 72 %). Dans cette étude les microphanérophytes étaient les plus dominants (60 %) suivis des nanophanérophytes et des mésophanérophytes. La phytogéographie a révélé que les Taxons communs à la région Guinéo-Congolaise et à la région Soudano-Zambézienne étaient les espèces végétales les plus représentées (42,5 %). Parmi ces taxons, Anogeissus leiocarpus, était le plus sollicité (77,77 %). Les organes des taxons les plus utilisés étaient les feuilles (40 %) et le mode d’administration le plus dominant était la décoction (46 %). Conclusion : Ces résultats révèlent que les plantes médicinales jouent un rôle prépondérant dans la lutte antifongique dans le département de Korhogo. Mots-clés : Ethnobotanique, Plantes antifongiques, Département de Korhogo, Herboristes, Tradipraticiens
Pendampingan Pengurus Objek Wisata Alam Pattalassang dalam Pengembangan Desa Wisata yang Mandiri Energi
Authors: Dessy Ana Laila Sari  , Hilda Ashari  , Akhyar Muchtar  , Elfira Makmur  , Muh. Iswal Burhan
Published: November 2023

Desa wisata merupakan fenomena yang berkembang pesat sebagai upaya untuk mengintegrasikan pariwisata, pembangunan ekonomi lokal, dan pelestarian lingkungan. Artikel ini membahas upaya pemberdayaan pengelola Wisata Alam Tallassappang dalam mendorong pengembangan desa wisata mandiri berbasis energi. Pendekatan mencakup transfer pengetahuan dan keterampilan yang diperlukan untuk mengelola aspek-aspek energi dalam operasional wisata. Pendampingan juga diharapkan dapat membantu pengembangan kewirausahaan lokal. Selain itu, artikel ini menitikberatkan pada pentingnya pendampingan dalam membangun kesadaran masyarakat lokal tentang manfaat dan tantangan pengelolaan energi berkelanjutan. Dengan membangun pemahaman ini, masyarakat dapat lebih aktif terlibat dalam prakarsa energi berkelanjutan. Cangkupan dalam aspek kelembagaan di area Kelurahan Kalabbirang juga dilakukan, guna mendukung pengembangan desa wisata berbasis energi.  Diharapkan bahwa melalui pendampingan yang holistik, pengelola wisata dapat menjadi agen perubahan dalam mewujudkan desa wisata mandiri berbasis energi, memberikan manfaat ekonomi yang berkelanjutan, dan meningkatkan kualitas hidup masyarakat lokal sambil melestarikan keanekaragaman budaya dan alam.
Pertukaran Sosial dalam Peran Ganda Perempuan: Studi Kasus tentang Pekerjaan Rumah Tangga dan Karier Profesional
Authors: Dimas Arsy Yanto  , Halimah Nur Churil Aini  , Meydina Tri Luvianasari
Published: November 2023

Social Exchange in Women's Dual Roles: A Case Study of Housework and Professional Career. This research investigates the dynamics of social exchange involved in women's dual roles, with a focus on the fulfillment of household work and professional career development. Social exchange theory is used as a framework to analyze how women manage their roles in an increasingly complex contemporary society. Through in-depth case studies, this research explores women's experiences in managing household responsibilities along with their efforts to achieve success in professional careers. The results of this study provide insight into the challenges and opportunities they face in carrying out their dual roles, as well as their impact on gender equality in society. The results of this research have important implications in efforts to increase gender equality and encourage more inclusive social change. This study also provides a basis for better policy thinking in supporting women in navigating their dual roles and achieving success in various aspects of their lives.
General Knowledge Article
Authors: Kumar Dinesh
Published: November 2023

The following is a partial link of scientific journals
Obravnava endometrioze v pomenopavznem obdobju
Authors: Belak Magdalenić Urška , Frangež Helena Ban , Korošec Sara
Published: November 2023

Endometrioza je bolezen, ki lahko prizadene 2–5 % vseh žensk v pomenopavznem obdobju. Gre za bolezen, pri kateri se endometrijske žleze in stroma nahajajo zunaj maternice. O pomenopavzni endometriozi je zaenkrat v literaturi še malo znanih podatkov. V sklopu diagnosticiranja je v tem obdobju v ospredju predvsem skrb, da gre morda za maligno bolezen. Poročila v literaturi opisujejo ponovitev endometrioze v pomenopavznem obdobju kot tudi nastanek endometrioze »de novo«. Zdravljenje izbire simptomatske endometrioze v pomenopavzi je kirurško z odstranitvijo vsega vidnega endometriotičnega tkiva zaradi višjega tveganja za ponovitev bolezni in preobrat v maligno bolezen. Hormonsko zdravljenje po menopavzi (MHZ) se pogosto uporablja za lajšanje simptomov in preprečevanje izgube kostne mase. Obstajajo raziskave, ki dokazujejo, da MHZ lahko ponovno aktivira endometriotična žarišča in celo spodbuja maligno preoblikovanje žarišč pri ženskah z anamnezo endometrioze. Glede na ne povsem razjasnjena tveganja MHZ pri tovrstnih bolnicah se svetuje dodatna previdnost.
The Efficacy of Interest Subsidies as an Investment Incentive Instrument
Authors: ÇELEBİ Emir
Published: November 2023

Purpose: Since interest subsidies have always been a crucial part of investment policy in Türkiye, the study focused on the efficacy of interest subsidies as an investment incentive.

Methodology: First, the interest and cash-flow sensitivity of the investment expenditure are explored before touching upon the literature on the interest and credit subsidy sensitivity of the investments without omitting the influential financing parameters. Then, financing parameters in sectoral balance sheets and the financing outlook of the Turkish companies are examined to infer which type of credit subsidy should be preferred, before bringing concrete observations from the recent capital formation trend.

Findings: First, funding conditions, economic cycles and market frictions stemming from informational asymmetry influence the efficacy of the interest subsidies. Second, interest subsidies only become effective when economic and financial volatility surge, which implies a lesser effect than quasi-tax incentives. Third, monetary and interest subsidy authorities should coordinate. Finally, the credit guarantee mechanism is more powerful than interest subsidies to achieve policy goals since credit accession is a way bigger problem for Turkish companies.

Originality: To my knowledge, this is the first article ever written specifically examining the efficacy of interest subsidies in Türkiye, although there were many studies focusing on investment incentives in general.
Nurse PerformanceThrough Motivation and Work Discipline on Productivity (Case at a Hospital in DKI Jakarta)
Authors: Cicih Ratnasih  , Bambang Bernanthos  , Syaiful  , Kurniawan Angga
Published: November 2023

This study examines the influence of factors related to the performance of hospital nurses in DKI Jakarta. These factors include motivation, work discipline which then in this study functioned as an independent variable and productivity as an intervening variable that affects the performance of nurses who functioned as a dependent variable. This research was conducted by quantitative research methods. This research was conducted by hospitals in DKI Jakarta in August – December 2022. The population in this study was hospital nurses in DKI Jakarta as many as 400 respondents. The instrument in this study is a questionnaire consisting of 40 questions. Based on the results of research from 400 respondents there is a direct and significant influence between motivation and work productivity which is 3,847%, there is a direct and significant influence relationship between work discipline and productivity which is 8,936%, there is a direct and significant influence between motivation and nurse performance which is 4,599%, there is a direct and significant relationship between work discipline and nurse performance which is 8,936%, There is a significant relationship between productivity and nurse performance which is 13.834%, there is a direct and significant influence between motivation and productivity through nurse performance which is 2.340%, %, there is a direct and significant influence between discipline and productivity through nurse performance which is 2.641%.
Effects of Water Hardness on Egg Hatchability and Larval Survival of Aquarium Fish, Danio rerio
Authors: Chanu Thongam Ibemcha , Rawat Kiran Dube , Sharma Arun , Das Arabinda , Nightingale Devi B.
Published: November 2023

Studies were conducted to determine the effects of water hardness on egg hatchability and larval survival of aquarium fish Danio rerio. The fertilized eggs were incubated at 27 °C at six levels of water hardness: 5, 32, 63, 127, 220 and 315 mg 1-1 CaCO3. Incubation period of eggs increased with increase in water hardness. The mean hatching rate was found increased in 5 to 63 mg 1-1 hardness. However, above the hardness of 63 mg 1-1 the mean hatching rate fluctuated. The larval survival rate of 12.62% was observed in 5 mg 1-1 hardness, which showed an increasing trend with increase in water hardness level up to 63 mg 1-1 CaCO3. However, survival rate decreased with hardness level beyond 63 mg 1-1. The results showed that larval survival was significantly influenced by water hardness. Very soft water (5 to 32 mg 1-1) and very hard water (315 mg 1-1 and above) were not found suitable for larval rearing. A water hardness of 63 mg 1-1 CaCO3 was thus found to be the suitable concentration for hatching and larval survival of D. rerio.
L’action culturelle et artistique sur le campus universitaire de Bordeaux (1968-1995). Formes de modernisation d’un cadre éducatif, innovations et mécanismes d’inertie
Authors: Callède Jean-Paul
Published: November 2023

L’étude examine la mise en place progressive de l’animation culturelle et artistique sur le campus universitaire de Bordeaux (France) entre 1968 et 1995. Différents domaines y contribuent : ciné-clubs, musique, théâtre. En revanche, celui des arts plastiques est nettement en retrait malgré des opportunités : présence décorative de plusieurs sculptures monumentales d’art contemporain, mise en place de la filière d’enseignement en arts plastiques. L’examen de la presse écrite, l’identification des acteurs engagés et la passation d’une douzaine d’entretiens permettent de voir comment les formes de modernisation de l’université sont tributaires d’échelles de référence singulières : entre espérances liées à l’ouverture de l’école des beaux-arts sur l’université et contraintes académiques propres au Vieux Continent, réalisation des potentialités artistiques à l’université pour la musique et le théâtre inspirée du quotidien des campus nord-américains.
La recherche-création dans l’organisation universitaire. Quatre scénarios pour penser la créativité dans la division du travail scientifique
Authors: Gauthier Philippe
Published: November 2023

Cet article vise à esquisser quatre scénarios d’intégration de la recherche-création (RC) dans l’organisation universitaire. Cette intégration pose des défis qui, le plus souvent, sont considérés sur le plan épistémologique mettant en concurrence la connaissance produite par la RC avec celle produite par les autres formes de recherche qui ont défini l’université moderne. Pourtant, considérée sous l’angle de l’organisation administrative du travail scientifique, l’émergence de la RC soulève des problèmes dont l’urgence justifie de réfléchir aux modalités de son intégration. L’exercice de prospective proposé ici souligne la fécondité de ce regard organisationnel et présente un cadre méthodologique permettant de tirer partie du travail créatif en recherche. Les scénarios imaginés soulignent la nature et la diversité des formes organisationnelles auxquelles peut mener l’intégration universitaire de la RC.
Le programme Passeurs culturels pour les futures enseignantes et les futurs enseignants de l’Université de Sherbrooke : un mariage heureux entre les arts, la culture et l’éducation
Authors: Lépine Martin , Nadeau Anne , Bélanger Audrey
Published: November 2023

En 2017, trois ans après l’adoption de sa Politique institutionnelle des arts et de la culture, l’Université de Sherbrooke a vu naître sur son campus le programme Passeurs culturels. Cette formule originale d’accompagnement et de recherche offre aux futures enseignantes et aux futurs enseignants de la Faculté d’éducation l’accès à des spectacles d’arts vivants, des expériences de médiation culturelle et le réinvestissement par des activités pédagogiques dans certains cours. Après quatre phases d’enquête qui ont permis d’analyser les retombées du programme sur les personnes impliquées et de brosser un portrait des pratiques culturelles et des conceptions de la culture chez le futur corps enseignant, les résultats confirment l’apport d’un tel programme sur la progression du rapport personnel et pédagogique à la culture.
L’université contemporaine comme scène culturelle : le cas de Montréal
Authors: Rouleau Jonathan
Published: November 2023

La genèse de la notion de scène en analyse culturelle est issue de la reconnaissance du dynamisme culturel émergeant de villes universitaires. Néanmoins, la façon dont ce rapport s’articule n’a pas fait l’objet d’une attention dirigée dans les travaux pionniers, les études sur les rôles des universités ayant surtout insisté sur leurs impacts économiques et sur leur fonction dans l’innovation régionale. Cette contribution met en lumière le rôle des universités dans la construction et la vitalisation de scènes culturelles à Montréal et nous invite à aborder le rôle culturel de l’université en ville à travers les médiations qu’elle engendre et opère. En situant l’université comme un dispositif de l’écosystème urbain à travers lequel des expressions culturelles circulent de façon formelle et informelle, des logiques matérielles, symboliques et politiques sont rendues visibles et informent la compréhension de l’inscription culturelle des universités en ville.
L’Université des Arts de l’Équateur dans la ville de Guayaquil : origines politiques, transformations pédagogiques et identités culturelles
Authors: Cardoso Pablo , Noriega Ramiro
Published: November 2023

L’Université des Arts de l’Équateur est un projet éducatif créé en 2013 dans le cadre d’une réforme du système d’enseignement supérieur, qui s’inscrivait elle-même dans une politique gouvernementale visant à transformer les structures de développement du pays. Cet article passe en revue le processus de gestation de cette institution éducative publique et analyse son impact à travers différentes dimensions : i) la relation de l’université avec le territoire qu’elle habite, ii) son modèle éducatif original dans le domaine des arts et sa signification dans le système d’enseignement supérieur équatorien, iii) le dialogue entre les productions créatives de l’université et le champ artistique local. À partir d’une approche multidisciplinaire et de références théoriques critiques hétérodoxes, cet article mobilise des connaissances produites pour établir un compte rendu de l’histoire courte mais significative de ce projet universitaire innovant.
A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis
Authors: Lin Jiamin , Zhang Pingping , Liu Wei , Liu Guorong , Zhang Juan , Yan Min , Duan Yuyou , Yang Na
Published: November 2023

Lipid metabolism plays a critical role in cancer metastasis. However, the mechanisms through which metastatic genes regulate lipid metabolism remain unclear. Here, we describe a new oncogenic-metabolic feedback loop between the epithelial-mesenchymal transition (EMT) transcription factor ZEB2 and the key lipid enzyme ACSL4 (long-chain acyl-CoA synthetase 4), resulting in enhanced cellular lipid storage and fatty acid oxidation to drive breast cancer metastasis. Functionally, Depletion of ZEB2 or ACSL4 significantly reduced lipid droplets (LD) abundance and cell migration. ACSL4 overexpression rescued the invasive capabilities of the ZEB2 knockdown cells, suggesting that ACSL4 is crucial for ZEB2-mediated metastasis. Mechanistically, ZEB2 activated ACSL4 expression by directly binding to the ACSL4 promoter. ACSL4 binds to and stabilizes ZEB2 by reducing ZEB2 ubiquitination. Notably, ACSL4 not only promotes the intracellular lipogenesis and lipid droplet accumulation but also enhances fatty acid oxidation (FAO) and ATP production by upregulating the FAO rate-limiting enzyme CPT1A (carnitine palmitoyltransferase 1 isoform A). Finally, we demonstrated that ACSL4 knockdown significantly reduced metastatic lung nodes in vivo. In conclusion, we reveal a novel positive regulatory loop between ZEB2 and ACSL4, which promotes LD storage to meet the energy needs of breast cancer metastasis, and identify the ZEB2-ACSL4 signaling axis as an attractive therapeutic target for overcoming breast cancer metastasis.ZEB2 activates FAO through transcription of ACSL4ACSL4 regulates lipid metabolism through FAO, promoting breast cancer metastasis Targeting ZEB2-ACSL4 signaling axis inhibits breast cancer metastasisWe describe a novel positive feedback loop between ZEB2 and ACSL4 that results in enhanced cellular lipid storage and FA oxidation to drive breast cancer metastasis.
FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and piRNA production
Authors: Li Zhiming , Liu Xingping , Zhang Yan , Li Yuanyuan , Zhou Liquan , Yuan Shuiqiao
Published: November 2023

Spermiogenesis is a critical, post-meiotic phase of male gametogenesis, in which the proper gene expression is essential for sperm maturation. However, the underlying molecular mechanism that controls mRNA expression in the round spermatids remains elusive. Here, we identify that FBXO24, an orphan F-box protein, is highly expressed in the testis of humans and mice and interacts with the splicing factors (SRSF2, SRSF3, and SRSF9) to modulate the gene alternative splicing in the round spermatids. Genetic mutation of FBXO24 in mice causes many abnormal splicing events in round spermatids, thus affecting a large number of critical genes related to sperm formation that were dysregulated. Further molecular and phenotypical analyses revealed that FBXO24 deficiency results in aberrant histone retention, incomplete axonemes, oversized chromatoid body (CB), and abnormal mitochondrial coiling along sperm flagella, ultimately leading to male sterility. In addition, we discovered that FBXO24 interacts with MIWI and SCF subunits and mediates the degradation of MIWI via K48-linked polyubiquitination. Furthermore, we show that FBXO24 depletion could lead to aberrant piRNA production in testes, which suggests FBXO24 is required for normal piRNA biogenesis. Collectively, these data demonstrate that FBXO24 is essential for sperm formation and piRNA production by regulating mRNA alternative splicing and MIWI degradation during spermiogenesis.
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids
Authors: Cao Xiuling , Wu Xiang , Zhao Lei , Zheng Ju , Jin Xuejiao , Hao Xinxin , Winderickx Joris , Liu Shenkui , Chen Lihua , Liu Beidong
Published: November 2023

Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a yeast imaging-based screen, we identified 84 potential synphilin-1 (SY1) IB regulators and isolated the conserved sphingolipid metabolic components in the most enriched groups. Furthermore, we show that, in both yeast cells and mammalian cells, SY1 IBs are associated with mitochondria. Pharmacological inhibition of the sphingolipid metabolism pathway or knockout of its key genes results in a delayed IB maturation and increased SY1 cytotoxicity. We postulate that SY1 IB matures by association with the mitochondrion membrane, and that sphingolipids stimulate the maturation via their membrane-modulating function and thereby protecting cells from SY1 cytotoxicity. Our findings identify a conserved cellular component essential for IB maturation and suggest a mechanism by which cells may detoxify the pathogenic protein aggregates through forming mitochondrion-associated IBs.
TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis
Authors: Chotiner Jessica Y. , Leu N. Adrian , Yang Fang , Cossu Isabella G. , Guan Yongjuan , Lin Huijuan , Wang P. Jeremy
Published: November 2023

Meiotic progression requires coordinated assembly and disassembly of protein complexes involved in chromosome synapsis and meiotic recombination. The AAA+ ATPase TRIP13 and its orthologue Pch2 are instrumental in remodeling HORMA domain proteins. Meiosis-specific HORMAD proteins are associated with unsynapsed chromosome axes but depleted from the synaptonemal complex (SC) of synapsed chromosome homologues. Here we report that TRIP13 localizes to the synapsed SC in early pachytene spermatocytes and to telomeres throughout meiotic prophase I. Loss of TRIP13 leads to meiotic arrest and thus sterility in both sexes.
Trip13
-null meiocytes exhibit abnormal persistence of HORMAD1 and HOMRAD2 on synapsed SC and chromosome asynapsis that preferentially affects XY and centromeric ends.
Trip13
heterozygous (
Trip13
+/-
) mice also exhibit meiotic defects that are less severe than the
Trip13
-null mice, showing that TRIP13 is a dosage-sensitive regulator of meiosis. Localization of TRIP13 to the synapsed SC is independent of SC axial element proteins such as REC8 and SYCP2/SYCP3. The N- or C-terminal FLAG tagged TRIP13 proteins are functional and recapitulate the localization of native TRIP13 to SC and telomeres in knockin mice. Therefore, the evolutionarily conserved localization of TRIP13/Pch2 to the synapsed chromosomes provides a spatial explanation for dissociation of HORMA domain proteins upon chromosome synapsis in diverse organisms.
Ethanol stress induces transient restructuring of the yeast genome yet stable formation of Hsf1 transcriptional condensates
Authors: Rubio Linda S. , Mohajan Suman , Gross David S.
Published: November 2023

In mammals, 3D genome topology has been linked to transcriptional states yet whether this link holds for other eukaryotes is unclear. Here we show that in budding yeast,
Heat Shock Response
(
HSR
) genes under the control of Heat Shock Factor (Hsf1) rapidly reposition in cells exposed to acute ethanol stress and engage in concerted, Hsf1-dependent intergenic interactions. Accompanying 3D genome reconfiguration is equally rapid formation of Hsf1-containing condensates. However, in contrast to the transience of Hsf1-driven intergenic interactions that peak within 10 min and dissipate within 1 h, Hsf1 condensates are stably maintained for hours. Moreover, under the same conditions, Pol II occupancy of
HSR
genes and RNA expression are detectable only later in the response and peak much later (>1 h). This contrasts with the coordinate response of
HSR
genes to thermal stress where Pol II occupancy, transcription, intergenic interactions, and formation of Hsf1 condensates are all rapid yet transient (peak within 2.5-10 min and dissipate within 1 h). Collectively, our data suggest that different stimuli drive distinct transcription, topologic, and phase-separation phenomena dependent on the same transcription factor and that transcription factor-containing condensates represent only part of the ensemble required for gene activation.
‘We cannot afford outsiderness’
Authors: Vist Torill , Holdhus Kari
Published: November 2023

This article addresses social inclusion/exclusion – specifically the kind of exclusion we describe as outsiderness – in relation to sustainable development and arts education. Our idea is to address and discuss this on an individual/micro level and as a topic of social sustainability. Inspired by Irwin and Springgay’s a/r/tography, Frank’s dialogical narrative analysis, and different walk-along methods, we also explore alternative formats of the scientific article. In this text, we will thus present what became five threads of inquiry into arts education’s potential contribution to social sustainability. These threads describe our path through this field and relate to 1) the position of the arts in the UN’s Sustainable Development Goal (SDGs), 2) social inclusion in the SDGs, 3) research on the arts and health, 4) social inclusion in the arts, and 5) research on outsiderness. Throughout the article, we also exemplify our walk-along discussions through narratives, revealing more of the motivations behind this text. We end the article with a discussion proposing relational arts education to help avoid outsiderness and to promote inclusion, care, social sustainability, and diverging voices or what we describe as counter-voices, in arts education.
Cover image: photo collage by Torill Vist
Reducing inequalities among species through an arts-based inquiry in early childhood teacher education
Authors: Nordbø Anne Lise , Fredriksen Biljana C.
Published: November 2023

This article is based on a study in outdoor arts-based education with Norwegian early childhood teacher students. Their teachers of drama and art & crafts (also the researchers and authors of this article) facilitated the specific arts-based learning environments and posed the following question: Which qualities of arts-based learning environments can challenge students to seek toward reduction of inequalities between themselves and more-than-human others?
Four narratives were constructed from four of the students’ visual, verbal and audio presentations of their experiences from the outdoor places they engaged with. The students described their processes of connecting to the more-than-human inhabitants of those places, and more-less explicitly expressed changes in their attitudes toward the inhabitants and materials encountered at the places. The narratives, and their analysis, make visible how the students’ arts-based engagements challenged their anthropocentric values and could potentially lead to reduction of inequalities between themselves and the more-than-humans they met at the places. The discussions at the end of the article focus on the first part of the research question and sum up four qualities of the arts-based environments that were present in the four narratives. These qualities are imagination, self-initiated actions, emphatic connections, and time for aesthetic engagement.
Cover photo: "Student D" (anonymous".
Re-storying SDG 14: life below water
Authors: Aaltonen Heli
Published: November 2023

In this text the focus is on re-telling multispecies stories about life below water, and the specific focus is on how to tell such stories, which awake moral agency in humans to care what happens with life below water. Sustainable development goal (SDG) number 14 Life below water concerns about “conserving and sustainable use the oceans, seas and marine resources for sustainable development”. To be able to achieve the goal there are created ten targets to create action for sustainable future. All ten targets are closely related with human use of life below water as a resource for own needs. What about thinking water as home for many living creatures and life below water as something we humans could have an empathic relationship with? The text suggests that the use of dramatic empathy in multispecies storytelling practice is close of the strategies of feministic care ethics where other-directedness and openness to difference may create empathic relationship with the other, which is essential for achieving attitude change and moral agency for more sustainable future.
Barns refleksjoner om forholdet mellom natur og mennesker i litterære samtaler om bildeboka De to gamle og livets tre
Authors: Krogstad Atle , Hovik Lise
Published: November 2023

Denne artikkelen utforsker et leseprosjekt som involverer en gruppe 4-5 år gamle barnehagebarn og den franske bildeboka Les deux vieux et l’arbre de vie [De to gamle og livets tre] av Patrick Fischmann, illustrert av Martine Bourre (2013). Prosjektet var et litterært formidlingsprosjekt, og en del av det kunstneriske forskningsprosjektet Lydhør i Kongsgården, med fokus på temaet frø. Artikkelen fordyper seg i hvordan barna uttrykker sine refleksjoner over forholdet mellom natur og mennesker innenfor konteksten av litterære samtaler med barna.
Prosjektet har relevans for FNs bærekraftsmål nr. 15, "Livet på jorda", som legger spesiell vekt på bevaring og utvikling av skoger. Prosjektet var inspirert av en pedagogisk tilnærming til lesing for barn, med vekt på barnas autonomi og deres evne til å konstruere mening (Solstad, 2015). I tillegg bruker vi den økokritiske analysemodellen kjent som The Phyto Analyzes Map (Guanio-Uluru, 2021) for å kaste lys over det komplekse samspillet mellom trær og mennesker slik det er fremstilt i barnelitteraturen.
Gjennom hele prosjektet viste barna lekne og tankevekkende refleksjoner, spesielt angående de biologiske og ernæringsmessige forholdene som kreves for frøspiring, som presentert i boken. Dessuten genererte de fantasifulle forslag til nye former for interaksjon mellom mennesker og trær, basert på en empatisk tilnærming som tar hensyn til behovene til både trær og mennesker.
Økologiske perspektiver i scenekunst for barn
Authors: Hovik Lise
Published: November 2023

Dette essayet diskuterer økologiske perspektiver i scenekunst for barn, og forholdet mellom kunst, mennesker, dyr og våre fysiske omgivelser i lys av ideer om posthumanisme, sympoiesis og kunstnerisk forskning. Essayet baserer seg på kunstneriske forskningsmetoder gjennom scenekunstprosjektet Verken Fugl eller Fisk (Hovik, 2017-23) for barnehagebarn, av og med Teater Fot, der forfatteren er kunstnerisk leder. Prosjektet utviklet seg i en kollektivt skapende og undersøkende prosess, som undersøker betydningen av affekt i scenekunst for barn, og som underveis i prosessen benyttet seg av posthumanistiske teorier i samspill med et sanselig teaterspråk. Forestillingen Animalium (Teater Fot, 2019-23) improviserer og leker med å viske ut forskjeller og forstyrre skillelinjer mellom dyr og mennesker, og undersøker hvordan vi kan sette oss selv til side, slik at kunst og natur kommer mer til syne. Essayet diskuterer noen nye økologiske tilnærminger til scenekunst for barn og oppsummerer med et forslag om å rette oppmerksomheten mot affekt og emosjonelt engasjement, betydningen av et «nytt vi» og fellesskap mellom arter, samt iscenesettelse av utopiske fremtider.
Foto: Mattias Ormestad
Climate action and creative climate justice
Authors: Eggen Erlend , Hovik Lise
Published: November 2023

The answer to SDG 13 Climate action in this special issue takes the form of a contribution that breaks with the academic genre and bypasses the established academic or artistic formats of the journal. Instead, this contribution opens the door to the climate activist movement, shining a light on the urgency of the hour and the issues that are paramount in the hearts of climate-engaged artists, educators and cultural workers. Klimakultur, a non-profit organization supporting and strengthening the climate and environmental ambitions of the arts and culture sector in Norway, has together with Rosendal Teater in Trondheim released what they call a Creative Climate Justice Guide. This publication serves as inspirational tool for climate action.
Cover image: Photo by Rosendal Teater and Klimakultur SA
Shadow talk
Authors: Searle, aka NIMI Naeem
Published: November 2023

As the old man looks into his shadow, he must reflect on his past choices, are we on the right path to improving society or are we simply following, a new energy crisis created for profiting from a new global climate agenda? Each generation has faced this dilemma and may have to face a new series of problems as the transition of energy moves forward. The artwork is created as a stencil, can be found in Stord, western Norway.
Cover image: Naeem Searle, aka NIMI. Detail from street artwork Shadow talk
Permacrisis, Conspiracy Stories and Metaphors
Authors: Musolff Andreas
Published: November 2023

Conspiracy stories (also known as ‘conspiracy theories’) pretend to provide truthful and unambiguous responses to crisis experiences and thrive in conjunction with the latter: the more crises, the more conspiracies! Hence, it is no surprise that the recent, extended and multi-level crises have been accompanied by a cacophony of ‘trending’ stories that see conspiracies behind, e.g. COVID-19, climate change, migration, economic stagnation and military conflicts. These conspiracy stories link up with global master-conspiracies (e.g. Great Reset, QAnon) as well as with localised violent protests based on conspiracy stories at national or regional levels.
Despite their oft-lamented factual and logical deficiencies, conspiracy stories have two important assets. One asset is their narrative structure that presents a ‘solution’ to the narrative ‘problem’, which is identified with the topical crisis. They tell a supposedly secret back-story that ‘explains’ the current crisis and, based on it, provide a glimpse of an innovative solution. Their second asset is their figurative, non-literal formulation in terms of metaphor scenarios and metonymies, which enables users to mentally cancel part of their stories when they are exposed as untrue, and thus to maintain the story as a whole.
       The article provides a corpus-based analysis of metaphor use in conspiracy stories about COVID-19 in the UK, America and Germany. It explains their function and sketches perspectives for further research. It also discusses the chances of “reframing” metaphor-enhanced conspiracy stories during (perma-)crises and argues that such an endeavour must not restrict itself to fact-checks and -corrections. Instead, the narrative appeal of conspiracy stories, based on their figurative structure, needs to be taken into account, in order to expose their potentially disastrous political and social consequences
EMISIONES DE MOTORES MOSQUITO Y SUS IMPACTOS
Authors: Hurtubia Ricardo , Jahn Wolfram , Sánchez Joaquín
Published: November 2023

Los motores mosquito, generalmente instalados en bicicletas, son cada vez más numerosos en nuestras ciudades por ser una alternativa de movilidad de muy bajo costo y muy conveniente para quienes trabajan haciendo reparto a domicilio de comida o paquetes pequeños. Estos motores son, además, contaminantes y ruidosos, pero hasta el momento hay poca información respecto a qué tan contaminantes son, comparados con otros vehículos relativamente similares. Esto facilita la desinformación de quienes compran o utilizan estos motores y del público en general, dificultando además la labor fiscalizadora y la implementación de programas para el recambio tecnológico.
Secondary Chondrosarcoma of the Clavicle: A Case Report
Authors: Punja Abhimanyu B , Vaishali DM
Published: November 2023

Chondrosarcomas are uncommon cartilaginous tumours and are the third most common tumours arising from the bone. These tumours are low to high grade malignant chondroid tumours. Most of these lesions arise de novo and are considered primary chondrosarcomas. Tumours that develop from the cartilaginous cap of existing benign tumours like enchondroma or osteochondroma are known as secondary chondrosarcomas. Herein, the authors presented a case of a 41-year-old man who presented with a history of pain and swelling in his left clavicle for a duration of six months. Upon examination, clinicians felt a hard mass in the left clavicle region, prompting them to explore radiological insights. A radiograph revealed a lobulated sclerotic region overlying the medial aspect of the left clavicle. Computed Tomography (CT) further revealed an exophytic lesion arising from the clavicle. Magnetic Resonance Imaging (MRI) further characterised the lesion and raised suspicion of a complex malignant lesion of chondroid origin. Histopathological analysis confirmed it to be a chondrosarcoma of the clavicle. Subsequently, the patient underwent tumour excision with partial claviculectomy. Secondary chondrosarcomas are low to high grade malignant chondrogenic bone tumours that arise in pre-existing benign tumours. They may develop in osteochondromas, enchondromas, fibrous dysplasia, Paget’s disease, irradiated bone, and synovial chondromatosis. Although sarcomatous transformation is common in osteochondromas, secondary chondrosarcomas of the clavicle are extremely rare.
Physiotherapy Perspective in the Rehabilitation of Traumatic Brachial Plexus Injury in a Patient with Polytrauma: A Case Report Emphasising an Early Approach
Authors: Kumar K Suraj , Sahu Seema , Harjpal Pallavi
Published: November 2023

Traumatic peripheral nerve damage from Road Traffic Accidents (RTA) can cause severe impairment and loss of function in the upper and lower limbs. A significant portion of acute peripheral nerve injuries affects the upper limb, particularly the brachial plexus. The treatment for complete brachial plexus injury may involve surgery and intensive physiotherapy to help the nerves regenerate and reinnervate the muscles. A 17-year-old male was referred to the Neurology department from a primary healthcare centre after being involved in RTA that resulted in a fall on the right-side. Investigatory findings revealed a head injury with Subarachnoid Haemorrhage (SAH), fractures of the right tibia shaft, right clavicle lateral shaft, and right lower limb. Following surgery, the patient experienced difficulty in performing movements with the right upper limb, along with pain and tingling sensations. As a result, the patient was referred to physiotherapy. During physiotherapy, the patient received sensory re-education sessions lasting 15-20 minutes each, as well as bilateral training sessions lasting 20 minutes each, for a total of four weeks. Over the course of the treatment, the patient demonstrated overall improvement in hand function, including proper grasp and opposition. This improvement was reflected in the brachial assessment tool, Upper Extremity (UE) functional index, and functional independence measure. These positive outcomes underscore the importance of early neuro-physiotherapeutic rehabilitation for patients with brachial plexus injuries, as it can significantly enhance their overall well-being and quality of life.
Big Five Personality Domains and their Impact on Problematic Mobile Phone Use among Medical Students in a Rural Tertiary Care Centre in Tamil Nadu India: A Cross-sectional Study
Authors: Muniyapillai Tamilarasan , Selvaraju Maniprabhu , Kulothungan Karthikeyan , George Neethu , Dharmaraj Rock Britto , Vignesh K Nawin Jai
Published: November 2023

Introduction: The increasing usage of smartphones across the globe has resulted in considerable changes in people's daily lives, especially in terms of personality traits among adults. Research shows that the Big Five personality traits influence Problematic Mobile Phone Use (PMPU). Aim: To estimate the prevalence of PMPU using the Mobile Phone Problem Use Scale (MPPUS-10) and to evaluate the personality predictors of PMPU using the Big Five Inventory (BFI) questionnaire. Materials and Methods: A cross-sectional survey was conducted among 289 medical students at a rural tertiary care centre in Tamil Nadu, India from November 2021 to April 2022. The questionnaire consisted of three sections. The first section collected demographic characteristics, the second section included questions on the MPPUS-10, and the third section contained questions from the BFI questionnaire. Reliability analysis was conducted to assess the internal validity of the MPPUS-10 questionnaire. Exploratory factor analysis using principal component analysis with varimax rotation and Kaiser normalisation was performed to measure the structural validity of the MPPUS-10 scale. A multiple linear regression model was applied to determine the relationship between PMPU and the personality domains. Results: The prevalence of PMPU among medical students was found to be 106 (36.7%). Spearman's rank correlation revealed a negative correlation between agreeableness personality (r=- 0.307, p-value <0.001) and conscientiousness personality (r=-0.369, p-value <0.001) with PMPU. Additionally, a positive correlation was observed between neurotic personality and PMPU (r=0.325, p-value <0.001). Multiple linear regression analysis demonstrated that agreeableness, conscientiousness, and neuroticism significantly predicted 44.4% of the scores on the PMPU (F=23.276, p-value <0.001 at the 1% level). Therefore, individuals with lower levels of agreeableness, conscientiousness, and higher levels of neuroticism scored higher on the MPPUS-10 scale. Conclusion: The prevalence of PMPU among medical students was found to be high, requiring attention. Individuals with lower levels of agreeableness and conscientiousness, as well as higher levels of neuroticism, were more likely to exhibit PMPU.
Anaesthetic Management of Caesarean Section in Asymptomatic COVID-19 Positive Parturients with Abnormal Laboratory Findings: A Series of 15 Cases
Authors: David M Mohan , Bharath Megha , Rahman Afeefa Abdu , Ajmal PM
Published: November 2023

During the Coronavirus Disease 2019 (COVID-19) pandemic, Caesarean Sections (CS) were prioritised over other elective surgeries, leading to the identification and management of asymptomatic COVID-19 positive parturients. The present case series aimed to explore the possibility of laboratory abnormalities and adverse events that can occur in asymptomatic COVID-19 positive cases in the post-pandemic era when routine screening is no longer in place. Out of 141 asymptomatic COVID-19 positive CS patients, 15 cases were selected based on specific criteria. Demographic characteristics and clinical indicators were analysed, including age, gravidity, indications for CS, laboratory values {such as D-dimer, C Reactive Protein (CRP), and platelet count}, blood transfusion requirements, and obstetric outcomes. Indications for CS were predominantly previous CS and failure to progress. Laboratory abnormalities included elevated D-dimer, CRP, leukocyte count, and thrombocytopenia in some cases. Haemodynamic stability was maintained in all patients. The use of prophylactic anticoagulation was noted, potentially offering protection against thrombosis. Asymptomatic COVID-19 positive parturients can exhibit significant laboratory abnormalities. Thromboprophylaxis may play a role in mitigating thrombotic risks. The significance of the present case series lies in the fact that the laboratory abnormalities could only be detected since all positive patients were investigated as per hospital protocol, which will be missed in the post-COVID-19 era where routine investigations are not performed on asymptomatic patients. Therefore, healthcare workers should be aware of this possibility