bluuebunny/crossref_metadata_2025 huggingface dataset:
A case of stress induced cardiomyopathy with extracorporeal membrane oxygenation after total colectomy
Authors: Surwade Sanjay Madhukar , Mandal Tapas , Mehta Hemant , Mangeshkar Shaunak
Published: September 2019

Takotsubo cardiomyopathy or stress-induced cardiomyopathy is a cardiac syndrome of a reversible, transient left ventricular dysfunction that is caused by emotional and/or physical stress and surgery. Its clinical manifestations are similar to acute myocardial ischemia in absence of coronary artery lesion. It is more common in middle-aged women, and the prognosis is favourable. We report the case of a 32-year-old male patient who underwent a total colectomy, developed stress-induced cardiomyopathy and had poor outcome despite extracorporeal membrane oxygenation (ECMO).
PECULIAR FEATURES OF COMMUNICATION IN THE SPORTS INTERNET DISCOURSE
Authors: Shevchenko V. D. , Pisareva A. G.
Published: September 2019

The present article is devoted to the analysis of Internet discourse represented on web-sites of the British rugby teams. The aim of the research is identification of communicative situation features in the sport Internet discourse. The following tasks were fulfilled in order to achieve the aim: investigating peculiar features of language representation that is typical of a referential situation (an event, in this case a sports competition) and the analysis of communicative discursive situation that takes place during transmission of the message covering this event. The articles from the news sections of the web-sites were used as the source of empirical data.
The research focuses on representation of a socially important event in the sports discourse a sports match. The constituents of a situational model (Participants, their Actions, the Conditions) were singled out by means of the analysis of an extract belonging to the studied discourse. The analysis was carried out with the help of the traditional model of a news item: Event Who, What, Where, When, Why, How. The analysis of linguistic representation of a situational model revealed that the event is performed on a macro- and a micro-levels. That aspect depends on the authors focus either on the match, on the team as a whole or on the specific aspects of the event. The linguistic representation of both levels is demonstrated in the tables and illustrated by the relevant examples.
The following methods were used during the research: descriptive method, contextual-semantic method, method of content analysis as well as the method of discourse analysis. The peculiarities of communicative processes in the sports Internet-discourse were analyzed with the use of Hymes pattern S-P-E-A-K-I-N-G. The study of such elements as Setting and Scene, Participants, Ends, Act of Sequence, Genres is presented in the article.
LEGAL REGULATION OF MEDIATION AND REPRESENTATION AS TYPES OF BUSINESS ACTIVITY
Authors: Archakov M. Yu.
Published: September 2019

Proceeding from doctrinal and legislative definitions of entrepreneurial activity, which are presented in the article, the author carried out the analysis of ratio of the concepts mediation and representation. Based on a wide range of scientific and educational literature analysis, regulation provisions, similarities and differences of the activity types, named above are emphasized in the article as well as these categories relation to business area is defined. The institute of mediation is considered broadly and narrowly in legal and economic terms. The content and types of mediation institute are revealed. The distinctive features of mediation and representation included in the law are shown. Special attention is paid to a current situation with a united approach formation to core business activity understanding.
DETENTION OF THE SUSPECT: PROBLEM OF CALCULATION OF THE TERM
Authors: Starodubova G. V.
Published: September 2019

In the article the problem of calculation of the term of detention of the crime suspect is analyzed. Examples from investigative court practice of definition of the moment with which the current of 48 hours specified in the Constitution of the Russian Federation and the Code of Criminal Procedure of the Russian Federation begins are given. The conclusion about need of fixing for the protocol of the moment of bringing of the inquiry delayed in body or to the investigator is drawn. The problem of long bringing of the suspect for the reasons having objective character is analyzed. It is offered to fix the procedure of the subsequent judicial control of validity of a delay of transfer of the suspect to the investigator or investigator.
UNIFICATION OF THE CRIMINAL PROCEDURE LAW IN THE ASPECT OF HERMENEUTIC SCIENCE
Authors: Levchenko O. V. , Mishchenko E. V.
Published: September 2019

The article deals with the problematic issues of the process of unification of criminal procedure legislation. Criminal procedure law as a legal phenomenon is studied through the prism of the science of hermeneutics, which examines the problems associated with the meaning of language, its understanding, explanation, interpretation and other aspects that are important for the unification of legislation. The authors note that following hermeneutic logic, criminal procedure law is a science in the sense in which it operates with general basic concepts and makes it possible to bring a specific fact under a typical generalization developed by this science. In criminal procedure law, as in any other law, it is important to understand, explain and interpret its text. The algorithm of full understanding of the text of articles of the criminal procedure law in aspect of hermeneutic logic is offered. Examples of violation of hermeneutic logic are given in articles of the Code of Criminal Procedure, procedural branches of the Russian law and it is concluded that modern lawmaking should take into account the provisions of hermeneutic science in order to preserve the uniform consolidation and interpretation of the fundamental provisions affecting the practice of law enforcement agencies and the court.
NON-APPLICATION BY THE COURT OF AN ACT CONTRADICTING THE LAW: PROBLEM STATEMENT
Authors: Fetisova E. A.
Published: September 2019

This article deals with the specifi city of the non-use by the court of an act contrary to the law as a way of protection of civil rights. The main doctrinal positions on the nature of the right to protection and on methods of protection are set out. The article is particularly relevant because of the fact that so far no comprehensive studies have been carried out on the particularities of the non-application by the court of an act contrary to the law from the point of view of the institution of administrative justice and the protection of civil rights, on the one hand, and the principle of legality and independence of judges, on the other. This issue became particularly acute in view of the adoption by the Constitutional Court of the Russian Federation on December 6, 2017 of the Resolution № 37-P, the subject of which was the constitutionality of part 13 of the Article 12 of the Civil Code of the Russian Federation. On the example of judicial practice the author demonstrates the atypical nature of the considered method of protection as well as the procedural diffi culties arising in connection with the part 13 of Article 12 of the Civil Code of the Russian Federation. On the basis of theoretical and practical arguments, the author concludes that the non-use by the court of an act contrary to the law does not fi t into the traditional perspective of the protection of subjective rights and the institution of administrative justice.
REQUIREMENTS FOR CONSENT TO CONDUCT RESEARCH, TREATMENT OR DIAGNOSTICS IN THE AREA OF HUMAN GENOME
Authors: Povarov Yu. S.
Published: September 2019

The article is about the attribute characteristics of consent to conduct research (treatment, diagnosis) in the field of the human genome, enshrined in international and domestic legal acts, while revealing the autonomy and interrelation of relevant features. Considering that the collection of genetic information can be carried out in order to provide medical care and be accompanied by medical intervention, increased attention is paid to legal indications of consent to such an intervention (information of the person concerned, voluntariness and preliminary nature of consent, its clear expression). The author, among other things, emphasizes the need for legislative regulation (in the format of a multi-factor approach) of the temporal aspect of conciliation procedure; indicates the relevance of applying the rule of giving medical clarifications in the situation of a request for termination of medical intervention; justifies the expediency of considering the sign of an obvious expression of consent, first of all, from the position of the form of expression of consent and in the content-organizational plan.
CRIMINAL LIABILITY FOR DISCRIMINATORY CRIMES
Authors: Bobrova N. A.
Published: September 2019

We consider the composition of discriminatory crimes, primarily the composition of Article 136 of the Criminal Code of the Russian Federation. The shortcomings of this article, the reasons for its non-use are analyzed. The problem of differentiation of criminal and other types of responsibility for discriminatory offenses, as well as the problem of differentiation of discriminatory and lawful restriction of constitutional rights and freedoms of citizens is touched upon. The conclusion is made about the need to improve antidiscrimination legislation, the practice of its implementation, as well as the need for an anti-discrimination ideology and anti-discrimination education at the state level.
LEGAL SUPPORT OF IMPLEMENTATION OF DOCUMENTS OF STRATEGIC PLANNING OF SOCIO-ECONOMIC DEVELOPMENT OF THE SAMARA REGION IN THE CONDITIONS OF DIGITAL ECONOMY
Authors: Bortnikov S. P. , Ievleva M. M. , Shigin M. D.
Published: September 2019

Тhe article examines the issues of legal support for the implementation of strategic planning documents for the socio-economic development of the Samara Region in the digital economy, defines the ratio of the National Program Digital Economy and its regional component, providing for federal and regional projects of the digital economy, as well as the ratio of initiative and government programs of the Samara Region. Conclusions about the imperfection of strategic planning documents as regulators in the studied area of relations are made. The national program Digital Economy provides for the elimination of digital inequality of different regions, but does not solve the question of inequality of economic sectors: 1) how will technologically backward sectors of the economy develop, including in the Samara Region, can economic entities the digitalization process, whether it will entail even greater backwardness and lack of competitiveness of entire industries, given that the programs are designed to support large organizations that create infrastructure values; 2) what will happen with the employment of the population in the backward sectors of the economy in municipalities that are still far from the digitalization process; 3) how much will the role of transnational corporations, which have sufficient resources to absorb the achievements of the digital economy, in the functioning of regional and municipal economies, be enhanced.
ACTUAL PROBLEMS OF IMPROVING THE PROCEDURAL STATUS OF PARTICIPANTS OF THE PRE-TRIAL COOPERATION AGREEMENT
Authors: Bagautdinov K. F.
Published: September 2019

The mechanism of implementation of the pre-trial agreement on cooperation involves participantsin criminal proceedings both from the prosecution and the defense. However, their role in the pre-trial cooperation agreement is different. The purpose of the study is to identify the role, features of the procedural status of the parties to the pre-trial agreement on cooperation, their interaction to build an optimal model for the implementation of the agreement.
SUBCONSCIOUS MIND: A PERSPECTIVE FROM AQIDAH, SHARICA, AND TASAWWUF
Authors: Ismail Mahyuddin , Yusof Nurkarimah , Rani Anita Abdul
Published: September 2019

Purpose of the study: Subconscious mind training course has become a phenomenon nowadays. The technique is claimed to be effective and it is made a testimonial to attract more individuals to learn this method. This study aims to examine whether the concept of the subconscious mind and its practices comply with Islamic teachings or otherwise.

Methodology: The methodology applied is purely qualitative as it involves crossover studies such as Sharica, caqidah, tasawwuf, Islamic medicine practice, and psychology. The data gained were analysed by using induction and deductive approaches. The comparison method was also used to test the similarities and differences between the subconscious mind and Islamic approaches.

Main Findings: Results from this study showed that the subconscious mind concept is not a really accurate approach to personality changes. It can be seen from four points: (1) the turning point of the changes; (2) the mechanism of changes; (3) the factor of changes; and (4) the conditions of changes.

Applications of this study: The results of this study will help the authorities to assess and determine the rules relating to the use of the subconscious mind concept and its techniques. This study also will enhance the quality of the service of religious authorities in addressing contemporary issues that require deep research.

Novelty/Originality of this study: The findings of the study show that the concept of the subconscious mind is not totally complied to the Islamic teachings. Hence, a Muslim should choose a better approach as shown in Islam.
A CASE STUDY OF ISLAMIC DACWAH ACTIVITIES IN CORDILLERA ADMINISTRATIVE REGION, PHILIPPINES AMONG MUSLIM MINORITY
Authors: Guleng Marlon Pontino , Muhamat@Kawangit Razaleigh , Usman Abur Hamdi
Published: September 2019

Purpose of the Study: The curves of Islamic dacwah activities in the Philippines have faced ebbs and flows due to various internal and external constraints. In Cordillera Administrative Region (CAR), lots of responses had been received by the Islamic organization from the local Muslim societies on the dacwah activities which require further reform in a way of diversifying the dacwah efforts in the whole region. This research aims of identifying the response of Muslim society towards the Islamic dacwah activities in the Philippines.

Methodology: In this study, quantitative methodology research was applied and the data were analyzed using Statistical Package for the Social Sciences (SPSS) for Windows version 21 with a total number of 272 respondents.

Main Findings: The results showed the responses towards the Islamic dacwah activities in a Muslim society (mean=3.71); Muslim family and friends (mean=3.51) were at high level. However, findings regarding the responses from the government (mean=3.13) and non-Muslim society (mean=3.15) were at moderate level.

Implications: The findings are essential for Islamic da’wah organizations to redesign and formulate various dacwah programs in order to ensure better implication on the societies.
Respons Imun Humoral Anjing Lokal Betina Umur Lebih dari Satu Tahun Pasca Vaksinasi Rabies
Authors: Norawigaswari Nengah Desy , Suardana Ida Bagus Kade , Suartha I Nyoman
Published: September 2019

Pencegahan penyebaran rabies dilakukan dengan cara vaksinasi pada hewan pembawa rabies (HPR) antara lain anjing, kucing, dan kera dalam rangka pemberantasan penyakit rabies. Vaksinasi anjing di lapangan dilakukan oleh Dinas Peternakan Kabupaten Kota setiap tahun, di setiap banjar-banjar dan bahkan mendatangi rumah penduduk dari pintu ke pintu. Untuk mengetahui apakah HPR yang telah divaksinasi rabies memiliki titer antibodi yang protektif, telah dilakukan penelitian respons imun humoral anjing lokal betina pasca vaksinasi rabies. Penelitian dilakukan di Desa Gulingan, Kabupaten Badung dengan sampel darah dari 10 ekor anjing. Darah diambil dari vena cephalica antibrachii anterior menggunakan spuit 3 ml, kemudian dibiarkan agar terjadi pemisahan antara serum dengan darah. Serum dipindahkan ke eppendorf dan disentrifuse. Dari hasil pengujian menggunakan uji ELISA, 50% memiliki titer antibodi protektif (nilai OD > 0,5 IU) dan 50% titer antibodinya tidak protektif (nilai OD < 50%). Simpulannya adalah perlu dilakukan vaksinasi ulangan pada anjing yang tidak memiliki titer antibodi protektif dengan peningkatam metode vaksinasi untuk menghasilkan antobodi yang protektif.
Pengaruh Pemberian Asam Butirat terhadap Peningkatan Berat Badan Ayam Pedaging
Authors: Astari Ni Putu Widya , Berata I Ketut , Tono PG Ketut
Published: September 2019

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian asam butirat terhadap peningkatan berat badan ayam pedaging. Penelitian menggunakan 60 ekor ayam pedaging umur 1 hari dan dibagi menjadi 3 kelompok perlakuan yaitu A kelompok perlakuan tanpa asam butirat (kontrol), B kelompok perlakuan dengan pemberian asam butirat dosis 0,5 kg/ton pakan dan C kelompok perlakuan dengan asam butirat dosis 1 kg/ton pakan. Variabel yang diukur adalah berat badan ayam pedaging. Pada uji jarak berganda Duncan didapatkan hasil terhadap peningkatan berat badan ayam pedaging yang berbeda-beda antara kelompok ayam kontrol dengan kelompok ayam yang diberikan perlakuan dengan dosis asam butirat 0,5 kg/ton pakan dan 1 kg/ton pakan. Hasil penelitian menunjukan bahwa pemberian kombinasi asam butirat dalam pakan berpengaruh sangat nyata (P<0,01) terhadap peningkatan berat badan ayam pedaging.
PENERAPAN DATA MINING DENGAN ALGORITMA C4.5 UNTUK KALKULASI DATA DALAM AL-QUR’AN TERJEMAHAN
Authors: Rusli Asmira Mira
Published: September 2019

Al-Qur'an was delivered by Prophet Muhammad SAW to mankind to become a guide in life in the world, which has 30 Juz, 114 suras and 6,236 verses. In the Qur'an there are many words that are repeated in a surah on a particular topic. To find out the number of repetitions of the word, an application of data calculations is built in the Al-Qur'an translation that can facilitate the calculation of words. So that users can quickly find out the number of words that repeat and how accurate the data is. This application is made with C4.5 algorithm, one of the data mining methods. Using the C4.5 algorithm is expected to be able to solve the problem of search and calculation in the translation of the Qur'an. The advantages of the C4.5 algorithm are producing decision trees that can be easily interpreted, as well as acceptable and efficient levels of accuracy. In this case the accuracy of the C4.5 algorithm reaches 80%.

Keywords: al-quran, data mining, algoritma C4.5

Al-Qur’an disampaikan oleh Nabi Muhammad SAW kepada umat manusia untuk dijadikan pedoman dalam kehidupan di dunia, yang mempunyai 30 Juz, 114 surah dan 6.236 ayat. Dalam Al-Qur’an terdapat banyak kata yang berulang dalam suatu surah mengenai topik tertentu. Untuk mengetahui jumlah perulangan kata tersebut, maka dibangun sebuah aplikasi kalkulasi data dalam Al-Qur’an terjemahan yang dapat mempermudah pengkalkulasian kata. Sehingga pengguna bisa dengan cepat mengetahui jumlah kata yang berulang serta seberapa akuratnya data tersebut. Aplikasi ini dibuat dengan algoritma C4.5 salah satu metode data mining. Dengan menggunakan algoritma C4.5 diharapkan mampu menyelesaikan masalah pencarian dan pengkalkulasian dalam terjemahan Al-Qur’an. Kelebihan dari algoritma C4.5 yaitu menghasilkan pohon keputusan yang dapat dengan mudah diinterprestasikan, serta tingkat akurasi yang dapat diterima dan efisien. Dalamm kasus ini tingkat akurasi Algoritma C4.5 mencapai 80%.

Kata kunci: al-quran, data mining, algoritma C4.5
Posturography examination as a diagnostic tool in children - a review of the literature
Authors: Borek Joanna Monika , Malak Roksana Ewa , Matthews-Brzozowska Teresa , Samborski Włodzimierz
Published: September 2019

Introduction. Posturograph tests are used to assess the vestibular reflex, which can be helpful for specialists who analyze body balance disorders. Despite many studies on the stability of body posture in pediatric patients, there is still a lack of reliable analysis.Aim. Performing a review of the literature to verify the relationship between balance and body posture as well as stomatognathic system as a part of motor system and the craniofacial complex using a posturograph.Material and Methods. A review of the literature has been carried out for the posturographic examination as a diagnostic tool. The following work is for reference only. A review of the Google Schoolar database and PubMed was made. Keywords used in the search are: (children) and (posturography, posture control, balance, temporomandibular joint). The authors took into account reports published in Polish and English. For the purposes of this review, strict criteria for the inclusion and exclusion of research work have been created.Results. The authors analyzed 335 research papers, of which 5 articles were qualified after the analysis. Studies show that there is a relationship between posturographic examination and postural disorders in children. However, the results are not conclusive and further research is necessary before these results can be considered as fully generalized.Summary. It is necessary to standardize the research using a posturograph. There is a need for further research due to the lack of standardized measurements showing norms for individual age groups.
Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology
Authors: Malmberg Maja , Malm Tarja , Gustafsson Oskar , Wright Anthony , El Andaloussi Samir , Linden Anders , Ezzat Kariem
Published: September 2019

Amyloids are fibrillar protein aggregates that are associated with diseases such as Alzheimer’s disease, Parkinson’s disease, type II diabetes and Creutzfeldt–Jakob disease. The process of amyloid aggregation involves three pathological protein transformations; from natively-folded conformation to the cross-β conformation, from biophysically soluble to insoluble, and from biologically functional to non-functional. While amyloids share a similar cross-β conformation, the biophysical transformation can either take place spontaneously via a homogeneous nucleation mechanism (HON) or catalytically on an exogenous surface via a heterogeneous nucleation mechanism (HEN). Here, we postulate that the different nucleation pathways could serve as a mechanistic basis for an etiological classification of amyloidopathies, where hereditary forms generally follow the HON pathway, while sporadic forms follow surface-induced (including microbially-induced) HEN pathways. Furthermore, the conformational and biophysical amyloid transformation would lead the loss-of-function (LOF) of the natively-folded, soluble protein. This LOF could, at least initially, be the mechanism of amyloid toxicity even before amyloid accumulation reaches toxic levels. By highlighting the important role of non-protein species in amyloid formation and LOF mechanisms of toxicity, we propose a generalized mechanistic framework that could help better understand the diverse etiology of amyloid diseases and offer new opportunities for therapeutic interventions including replacement therapies.
Pengaruh Jumlah Mol Kroslinker Pada Selektifitas IIP Berbasis Polieugenol Terhadap Fe(III)
Authors: Djunaidi Muhammad Cholid , Haris Abdul , Pardoyo Pardoyo , K Rosdiana
Published: September 2019

Sintesis Ionic Imprinted Polymer (IIP) dilakukan dengan variasi penambahan crosslinker PEGDE (Polyethylene glycol diglycidilether) yang kemudian diuji selektivitas IIP terhadap ion logam Fe melalui proses adsorpsi. IIP merupakan metode mencetak ion logam yang terikat dalam polimer, selanjutnya dilepaskan dari matriks polimer menghasilkan cetakan yang sesuai terhadap ion target. Tujuan penelitian ini untuk menghasilkan IIP dan NIP dari polieugenol dengan variasi penambahan crosslinker PEGDE perbandingan sebanyak  1, 2 dan 3 mol, mengetahui pengaruh jumlah mol crosslinker terhadap selektivitas adsorpsi IIP yang melibatkan rongga imprint/cetakan, serta mengetahui pengaruh logam kompetitor terhadap selektivitas adsorpsi IIP terhadap logam Fe. Selektivitas adsorpsi ion logam Fe(III) dengan penambahan crosslinker PEDGE 3 mol lebih besar dibandingkan dengan penambahan crosslinker PEGDE 1 dan 2 mol. Selektivitas adsorpsi Fe lebih besar pada Fe-Cr dibandingkan dengan Fe-Cd dan Fe-Pb.

Influence of Crosslinker Mole Amount on the Selectivity IIP-Based Polyeugenol Towards Fe(III). The synthesis of IIP (Ionic Imprinted Polymer) was carried out using PEGDE (Polyethylene glycol diglycidilether) crosslinker addition in various moles which was then tested for IIP selectivity for Fe metal ions through the adsorption process. IIP is a method of metal ions printing which are bound in a polymer, then released from the polymer matrix to produce a suitable mold for the target ion. The purposes of this study were to produce IIP and non imprinted polymer (NIP) from polyeugenol with the addition of various moles of PEGDE crosslinkers as much as 1, 2 and 3 moles, and to determine the effect of the number of mole crosslinkers on the selectivity of IIP adsorption involving imprint/mold cavities, and the effect of competitor metals on IIP adsorption selectivity towards Fe metal. The selectivity of Fe (III) metal ion adsorption with the addition of 3 mole PEDGE crosslinkers was greater than the addition of 1 and 2 moles PEGDE crosslinkers. The selectivity of Fe adsorption is was greater in Fe-Cr compared to Fe-Cd and Fe-Pb.
The Distribution of Underrepresented Minorities in U.S. Orthopaedic Surgery Residency Programs
Authors: Adelani Muyibat A. , Harrington Melvyn A. , Montgomery Corey O.
Published: September 2019

Background:

Orthopaedic surgery has generally lagged behind other surgical subspecialties with respect to racial and ethnic diversity in its U.S. residency programs. Efforts have been made to increase the number of underrepresented minorities (URMs) applying to orthopaedic surgery residencies; however, the impact on diversity at the residency program level is unknown. The purpose of this study was to determine whether orthopaedic surgery residency programs have become more racially diverse over time.

Methods:

The Graduate Medical Education Track database was queried for individual racial/ethnic identification of orthopaedic surgery residents in U.S. Accreditation Council for Graduate Medical Education (ACGME)-accredited programs for 15 consecutive years (2002-2003 through 2016-2017). The number of URMs in each residency program during each academic year was recorded. The number of programs per year with no URMs, 1 URM, 2 URMs, and >2 URMs was recorded, and the change over time was assessed.

Results:

The number of programs per year with >1 URM resident decreased over time, from 61 programs in 2002 to 53 programs in 2016, with the trough being 31 programs in 2010 (p < 0.0001). The number of programs per year without any URM residents increased over the period of study, from 40 programs in 2002 to 60 programs in 2016, with the peak being 76 programs in 2011 (p < 0.0001).

Conclusions:

The number of residency programs with >1 URM resident has decreased significantly over time, suggesting that diversity at the program level is limited. Program-level diversity should be further examined as a potential barrier to the recruitment of URMs to orthopaedics. Difficulty attracting URM residents to certain programs may have the unintended consequence of effectively limiting potential positions for these candidates, which can decrease the odds of minority students matching into orthopaedics and, therefore, perpetuate the cycle of lack of diversity in our field.
Preoperative Risk Factors for Opioid Utilization After Total Hip Arthroplasty
Authors: Prentice Heather A. , Inacio Maria C.S. , Singh Anshuman , Namba Robert S. , Paxton Elizabeth W.
Published: September 2019

Background:

Opioid prescriptions following orthopaedic procedures may contribute to the opioid epidemic in the United States. Risk factors for greater and prolonged opioid utilization following total hip arthroplasty have yet to be fully elucidated. We sought to determine the prevalence of preoperative and postoperative opioid utilization in a cohort of patients who underwent total hip arthroplasty and to identify preoperative risk factors for prolonged utilization of opioids following total hip arthroplasty.

Methods:

A cohort study of patients who underwent primary elective total hip arthroplasty at Kaiser Permanente from January 2008 to December 2011 was conducted. The number of opioid prescriptions dispensed per 90-day period after total hip arthroplasty (up to 1 year) was the outcome of interest. The risk factors evaluated included preoperative analgesic medication use, patient demographic characteristics, comorbidities, and other history of chronic pain. Poisson regression models were used, and relative risks (RRs) and 95% confidence intervals (CIs) are presented.

Results:

Of the 12,560 patients who underwent total hip arthroplasty and were identified, 58.5% were female and 78.6% were white. The median age was 67 years (interquartile range, 59 to 75 years). Sixty-three percent of patients filled at least 1 opioid prescription in the 1 year prior to the total hip arthroplasty. Postoperative opioid use went from 88.6% in days 1 to 90 to 24% in the last quarter. An increasing number of preoperative opioid prescriptions was associated with a greater number of prescriptions over the entire postoperative period, with an RR of 1.10 (95% CI, 1.10 to 1.11) at days 271 to 360. Additional factors associated with greater utilization over the entire year included black race, chronic pulmonary disease, anxiety, substance abuse, and back pain. Factors associated with greater utilization in days 91 to 360 (beyond the early recovery phase) included female sex, higher body mass index, acquired immunodeficiency syndrome, peripheral vascular disease, and history of non-specific chronic pain.

Conclusions:

We identified preoperative factors associated with greater and prolonged opioid utilization long after the early recovery period following total hip arthroplasty. Patients with these risk factors may benefit from targeted multidisciplinary interventions to mitigate the risk of prolonged opioid use.

Clinical Relevance:

Opioid prescriptions following orthopaedic procedures are one of the leading causes of chronic opioid use; strategies to reduce the risk of misuse and abuse are needed. At 1 year postoperatively, almost one-quarter of patients who underwent total hip arthroplasty used opioids in the last 90 days of the first postoperative year, which makes understanding risk factors associated with postoperative opioid utilization imperative.
Decision Support Strategies for Hip and Knee Osteoarthritis: Less Is More
Authors: Sepucha Karen , Bedair Hany , Yu Liyang , Dorrwachter Janet M. , Dwyer Maureen , Talmo Carl T. , Vo Ha , Freiberg Andrew A.
Published: September 2019

Background:

As guidelines and payers increasingly recommend use of patient decision aids (DAs), evidence about the comparative effectiveness of available DAs is critical for organizations interested in implementing them. The primary purpose of this study was to compare 2 DAs with regard to their ability to help patients become informed and receive their preferred treatment (that is, make an informed patient-centered decision), shared decision-making, surgical rates, and surgeon satisfaction.

Methods:

We performed a multisite factorial randomized trial enrolling patients with hip or knee osteoarthritis. Patients were randomly assigned to use a long, detailed DA (long DA) or short, interactive DA (short DA). Eight surgeons were randomly assigned to receive a patient preference report detailing the patient’s goals and treatment preferences or to administer usual care.

Results:

We distributed 1,636 pre-visit surveys, 1,220 of which were returned (75% response rate), and 1,124 post-visit surveys, 967 of which were returned (86% response rate). The patients in the sample had a mean age (and standard deviation) of 65 ± 10 years, 57% were female, 89% were white non-Hispanic, and 67% had knee osteoarthritis. The majority (67.2%) made informed patient-centered decisions, and the rate did not vary significantly between the DA groups (p = 0.97) or between the surgeon groups (p = 0.23). Knowledge scores were higher for the short-DA group (mean difference = 9%; p < 0.001). More than half of the sample (60.5%) had surgery within 6 months after the visit, and rates did not differ significantly by DA or surgeon group. Overall, the surgeons were highly satisfied and reported that the majority (88.7%) of the visits were of normal duration or shorter.

Conclusions:

The DECIDE-OA study is, to our knowledge, the first randomized comparative effectiveness study of 2 orthopaedic DAs. The short DA outperformed the long DA with regard to knowledge scores and was comparable with respect to other outcomes. The surgeons reported high satisfaction and normal visit duration with both DAs.

Clinical Relevance:

Surgeons need to ensure that patients with osteoarthritis are well-informed and have a clear preference regarding whether to undergo hip or knee replacement surgery. The DAs used in this study may help surgeons involve patients in elective surgery decisions and meet the requirements of informed consent.
Concerns and Quality of Life of Cancer Survivors Across the Survivorship Trajectory: A Singapore Perspective
Authors: Chua Gek Phin , Ng Quan Sing , Tan Hiang Khoon , Ong Whee Sze
Published: September 2019

Background The aim of this study is to determine the main concerns of survivors at various stages of the cancer survivorship of the cancer survivorship trajectory and to assess whether these concerns have any effect on their quality of life (QOL). The overall goal was to use the insights from the study to guide practice on patient care. Methods A cross-sectional survey of 1107 cancer survivors diagnosed with colorectal, breast, lung, gynaecological, prostate or liver cancers from a cancer centre in Singapore. Eligible patients self-completed a questionnaire adapted from the Mayo Clinic Cancer Centre’s Cancer Survivors Survey of Needs. Results The top 5 concerns among all survivors were cancer treatment and recurrence risk (51%), followed by long-term treatment effects (49%), fear of recurrence (47%), financial concerns (37%) and fatigue (37%). Cancer treatment and recurrence risk, long-term treatment effects and fear of recurrence were amongst the top concerns across the survivorship trajectory. Mean QOL was 7.3 on a scale of 0 – 10. Completed treatment patients had higher QOL score than the newly diagnosed and on treatment patients and the patients dealing with recurrence or second cancer patients. Predictors for QOL included the economic status and housing type of patients and whether patients were concerned with pain and fatigue Conclusion This study confirms that cancer survivors in Singapore face multiple challenges and had various concerns at various stages of cancer survivorship, some of which negatively affect their QOL It is critical to design patient care delivery that appropriately address the various concerns of cancer survivors in order for them to cope and improve their QOL.
Multiple Iterative Labeling by Antibody Neodeposition (MILAN)
Authors: Cattoretti Giorgio , Bosisio Francesca Maria , Marcelis Lukas , Bolognesi Maddalena Maria
Published: September 2019

(What’s new in protocol Version 5: an expanded troubleshooting section, more validated antibodies)Multiplexing, labeling for multiple immunostains the very same cell or tissue section in situ, is of considerable interest. The major obstacles to the diffusion of this technique are high costs in custom antibodies and instruments, low throughput, scarcity of specialized skills or facilities. We have validated and detail here a method based on common primary and secondary antibodies, diffusely available fluorescent image scanners and routinely processed tissue sections \(FFPE). It entails rounds of four-color indirect immunofluorescence, image acquisition and removal \(stripping) of the antibodies, before another stain is applied. The images are digitally registered and the autofluorescence is subtracted. Removal of antibodies is accomplished by disulphide cleavage. In excess of 50 different antibody stains can be applied to one single section from routinely fixed and embedded tissue. This method requires a modest investment in hardware and materials and uses freeware image analysis software.
A versatile algorithm for estimating natural frequencies with high accuracy
Authors: Gillich Gilbert-Rainer , Nedelcu Dorian , Barbinta Constantin-Ioan , Gillich Nicoleta
Published: September 2019

Detection of damage requires an accurate estimation of the natural frequencies of the monitored structure. This paper introduces an algorithm implemented in Python which improves the frequency readability by increasing the number of spectral lines without requiring a signal extension in the time domain. We achieve this by overlapping several spectra calculated from the acquired signal repeatedly shortened. In this way, the overlapped spectrum gets an increased number of spectral lines. The dense mesh of spectral lines permits us to obtain a fine frequency resolution without being necessary an extension of the signal in the time domain. The high density of the spectral lines ensures a sufficient number of points on the main lobes that permits performing an efficient quadratic polynomial interpolation to find the maximizer. It represents the amplitude of the real frequency and is typically located on an inter-line position, thus cannot be found by standard frequency estimation. We implemented the algorithm in Python and tested it successfully for generated signals, containing one or more harmonics, with known frequencies.
The effect of system improvement on regulation of pressure inside pneumatic spring element and on transmission of acceleration
Authors: Tran Xuan Tien , Cirkl David
Published: September 2019

Following a patented solution, a seat which is possible to change its stiffness was created. The seat contains an actively controlled pneumatic spring element (the PSE). For the requirement of working faster and more precisely, an improvement was applied. This article focuses on a comparison of the effect of the improved system and the original system on regulation of pressure inside a PSE. For comparison, two system characteristics were used, the response time and the transmission of acceleration. The original and improved system were thoroughly studied and compared experimentally. The behavior of both systems is analyzed and evaluated. The function of pressure regulation is investigated under static conditions (without excitation) and the transmission of acceleration is performed under dynamic conditions (with excitation). The results describe the behavior of the system in two modes of controller setup: constant pressure and constant stiffness both under static and dynamic conditions.
Design study of a magnetoelectric-electromagnetic vibration energy converter for energy harvesting
Authors: Bradai Sonia , Naifar Slim , Kanoun Olfa
Published: September 2019

The aim of this paper is to design a combination of a magnetoelectric-electromagnetic (ME-EM) vibration converter in order to reach an improved energy outcome. In this paper, the influence of magnets polarization and magnetoelectric transducer and coil direction are investigated. For this purpose, a finite element model is developed using one coil, one ME transducer in a magnetic circuit. Simulation results show that a better magnetic field distribution and variation is reached, if the magnetic circuit magnets are placed in attraction. Radial polarization shows decisive advantages in comparison with axial polarization. The placement of coil parallel to the magnetic circuit direction and the magnetization of the ME transducer along its width is the optimal direction relative to the magnetic circuit.
Revising contemporary heat flux estimates for the Lena River, Northern Eurasia
Authors: Tananaev N. I. , Georgiadi A. G. , Fofonova V. V.
Published: September 2019

The Lena River (Lena R.) heat flux affects the Laptev Sea hydrology. Published long-term estimates range from 14.0 to 15.7 EJ·a−1, based on data from Kyusyur, at the river outlet. A novel daily stream temperature (Tw) dataset was used to evaluate contemporary Lena R. heat flux, which is 16.4 ± 2.7 EJ·a−1 (2002–2011), confirming upward trends in both Tw and water runoff. Our field data from Kyusyur, however, reveal a significant negative bias, −0.8 °C in our observations, in observed Tw values from Kyusyur compared to the cross-section average Tw. Minor Lena R. tributaries discharge colder water during July–September, forming a cold jet affecting Kyusyur Tw data. Major Tw negative peaks mostly coincide with flood peaks on the Yeremeyka River, one of these tributaries. This negative bias was accounted for in our reassessment. Revised contemporary Lena R. heat flux is 17.6 ± 2.8 EJ·a−1 (2002–2011) and is constrained from above at 26.9 EJ·a−1 using data from Zhigansk, approximately 500 km upstream Kyusyur. Heat flux is controlled by stream temperature in June, during the freshet period, while from late July to mid-September, water runoff is a dominant factor.
Effects of Mobile Health App Interventions on Sedentary Time, Physical Activity, and Fitness in Older Adults: Systematic Review and Meta-Analysis
Authors: Yerrakalva Dharani , Yerrakalva Dhrupadh , Hajna Samantha , Griffin Simon
Published: September 2019

Background

High sedentary time, low physical activity (PA), and low physical fitness place older adults at increased risk of chronic diseases, functional decline, and premature mortality. Mobile health (mHealth) apps, apps that run on mobile platforms, may help promote active living.

Objective

We aimed to quantify the effect of mHealth app interventions on sedentary time, PA, and fitness in older adults.

Methods

We systematically searched five electronic databases for trials investigating the effects of mHealth app interventions on sedentary time, PA, and fitness among community-dwelling older adults aged 55 years and older. We calculated pooled standardized mean differences (SMDs) in these outcomes between the intervention and control groups after the intervention period. We performed a Cochrane risk of bias assessment and Grading of Recommendations, Assessment, Development, and Evaluation certainty assessment.

Results

Overall, six trials (486 participants, 66.7% [324/486] women; age mean 68 [SD 6] years) were included (five of these trials were included in the meta-analysis). mHealth app interventions may be associated with decreases in sedentary time (SMD=−0.49; 95% CI −1.02 to 0.03), increases in PA (506 steps/day; 95% CI −80 to 1092), and increases in fitness (SMD=0.31; 95% CI −0.09 to 0.70) in trials of 3 months or shorter and with increases in PA (753 steps/day; 95% CI −147 to 1652) in trials of 6 months or longer. Risk of bias was low for all but one study. The quality of evidence was moderate for PA and sedentary time and low for fitness.

Conclusions

mHealth app interventions have the potential to promote changes in sedentary time and PA over the short term, but the results did not achieve statistical significance, possibly because studies were underpowered by small participant numbers. We highlight a need for larger trials with longer follow-up to clarify if apps deliver sustained clinically important effects.
Learning Environment, Studentsâ€™ Attitude and Performance in Quantitative Course Units: A Focus on Business Students
Authors: Semukono Freddie , . Alice Arinaitwe
Published: September 2019

This study examines the persistent poor performance in quantitative course units amongst undergraduate business students, using the case of Makerere University Business School. The data were collected from 346 third year students using a face-to-face administered questionnaire survey; and analysed using descriptive statistics, correlation and hierarchical regression analyses. The findings indicate that while learning environment and studentsâ€™ attitude are positively associated with performance in quantitative courses, studentsâ€™ attitude towards quantitative courses causes more variations in performance. Paucity of studies on performance in quantitative business courses deprived the study of the opportunity to cross validate the findings. Future studies should be conducted to confirm the results. Management of universities should consider learning environment and studentsâ€™ attitude when determining possible changes to enhance studentsâ€™ performance in quantitative courses. This study extends the predominantly mathematics studies to other business quantitative courses at university level.
Dropout in High Schools studentsâ€“Modeling a Case Study in the Vhembe District, Limpopo Province, South Africa
Authors: Kyei Kwabena A.
Published: September 2019

South Africa experiences a significant amount of dropouts of high school learners every year. Only about 45% of learners who start primary school in a given year write matriculation examinations after 10 years of schooling. A high dropout rate deprives the country of well-informed and competent future leaders. This study looks at the factors that underlie dropout in high schools in the Vhembe district. A random sample of 5 villages was selected from 25 villages which have high schools. A census of high school dropouts in these 5 villages was conducted. About 660 dropouts were obtained and interviewed. Applying regression modeling, this study shows that poor performance, attitude, punishment and pregnancy are the factors affecting dropout in Vhembe, and recommends that educators encourage learners to develop positive attitude to school work and also give extra assistance to under-performing learners, and sex education be given with seriousness to reduce unwanted pregnancies.
Challenges of Using ICT in assessing and Developing Studentsâ€™ affective Domain in Education
Authors: Abdulfatai Ismail , . Husein Osman Abdullahi
Published: September 2019

ICT is becoming an inevitable tool in education nowadays. For any academic activities to be effective, the use of ICT is imperative. There are also a lot of benefits and improvement that ICT has brought to the field of education. These benefits and development cut across all spheres of education, such as the aspect of content, instruction and evaluation. In area of evaluation, the cognitive and psychomotor aspects of evaluation are mostly developed, based on the fact that both can be easily accessed through ICT. However, in the aspect of affective domain, the level of assessment is low and not absolutely reliable because it deals with the feelings, interest and values that learner attached to the subject matter. Hence, this study aimed at finding an effective way that ICT can be used to assess studentsâ€™ affective domain in the process of evaluation. In order to get in-depth understanding of the subject matter, the study employs qualitative design by using semi-structured interview to elicit information from specialists in the field of communication technology. Findings from the study indicate that the use of ICT to evaluate student affective domain requires an illustrious, diligent, and enthusiastic ICT literate teacher. Equally, there is a need to develop software that will focus more on the evaluation of studentsâ€™ affective domain. Meanwhile, this area that will develop studentsâ€™ soft skills is greatly needed to produce good citizens, employees, and government of their individual community.