bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH MOTIVASI BELAJAR DAN LINGKUNGAN TEMAN SEBAYA TERHADAP MINAT MEMBACA MAHASISWA PAP FKIP UNS ANGKATAN 2017 – 2019
Authors: Kultsum Annisaa , Murtini Wiedy , Susantiningrum Susantiningrum
Published: June 2024

The purpose of this research is to find out: 1) the effect of learning motivation on students reading interests, 2) the effect of peer environment on students reading interests, and 3) the effect of learning motivation and peer environment on students reading interests. This study used quantitative descriptive research with correlational methods. The population in this study is students of Office Administration Education class of 2017-2019. The research sample was taken by proportionate stratified random sampling techniques which amount to 147 students. Data collection techniques using questionnaires and interviews. Data analysis techniques were using multiple linear regression analysis with IBM SPSS 25 programs. The results showed that: 1) there is a significant influence of learning motivation on reading interests. This is evidenced by the results of thitung (4.785) > ttabel (1,976) and significance values (0.000 < 0.05); 2) there is a significant influence of peer environment on reading interests. This is evidenced by thitung (2,009) > ttabel (1,976) and significance values (0.046 < 0.05); and 3) there is a significant influence on learning motivation and peer environment together on reading interests. This is evidenced by the results of Fhitung (15,896) > Ftabel (3.06) and significance values (0.000 < 0.05).
PERAN MANAJER PERSONALIA DALAM MEMOTIVASI KERJA KARYAWAN DI PT AKSARA SOLOPOS SURAKARTA
Authors: Miladia Shafina Arum , Murwaningsih Tri , Ninghardjanti Patni
Published: June 2024

The purpose of this research is to find out: Roles, obstacle and solutions of personnel manager in motivating employee’s work at PT Aksara Solopos Surakarta. The method used in this research is descriptive qualitative research method with a case study research approach. The results of research showed that: The role of the personnel manager in motivating the work of employees at PT Aksara Solopos Surakarta includes providing direction to employees, providing good examples for employees, personnel manager as employee counselors, and as activator positive working conditions; The obstacle faced by personnel managers in motivating employees' work includes several individual employee had a bad character and less problem solving solution form field managers; Solutions made by personnel managers to overcome obstacles in motivating employees' work include providing rewards and punishments and approaching employees.
PENGARUH TATA RUANG KANTOR DAN KOMUNIKASI KANTOR TERHADAP SEMANGAT KERJA PEGAWAI DISPERTAN PP KABUPATEN KARANGANYAR
Authors: Elviana Elva , Sawiji Hery , Winarno Winarno
Published: June 2024

The purpose of this study isto determine:  (1) find out whether there is an effect of office layout on the spirit of the employees in Dinas Pertanian, Pangan dan Perikanan Kabupaten Karanganyar, (2) find out whether there is an effect of office communication on the spirit of the employees in Dinas Pertanian, Pangan dan Perikanan Kabupaten Karanganyar, and (3) determine whether there is an influence between office layout and office communication on the spirit of the employees in Dinas Pertanian, Pangan dan Perikanan Kabupaten Karanganyar.

This research is a quantitative research using survey method. The population in this study were employees of the Dinas Pertanian, Pangan dan Perikanan Kabupaten Karanganyar. Sources of data in this study came from respondents and literature study. The sampling technique was done by simple random sampling. Data was collected through interviews, questionnaires and observations. The validity test technique uses Product Moment Correlation, while the reliability test uses Cronbach's alpha. The data analysis technique used multiple regression analysis techniques with the help of SPSS version 25.
The results showed that 1) There is a positive and significant effect of office layout on the spirit of the employees. This is evidenced by the tcount of 2,619 > ttable of 1,672, thus Ho is rejected and H1 is accepted. 2) There is a positive and significant effect of office communication on the spirit of the employees. This is evidenced by the tcount of 5,088 > ttable of 1,672, thus Ho is rejected and H2 is accepted. And 3) There is a positive and significant effect of office layout and office communication simultaneously on the spirit of the employees. This is evidenced by Fcount(33.053) > Ftable(3.159) then Ho is rejected and H3 is accepted. Thus, the overall results of this analysis support the proposed hypothesis.
Pengaruh motivasi, komunikasi, dan pengawasan terhadap disiplin kerja karyawan
Authors: Hapsari Afiffah Rika , Murtini Wiedy , Ninghardjanti Patni
Published: June 2024

Abstrak: disiplin. (2) apakah terdapat pengaruh komunikasi terhadap disiplin kerja karyawan. (3) ada tidaknya pengaruh pengawasan terhadap disiplin kerja pegawai. (4) apakah terdapat pengaruh motivasi, komunikasi, dan supervisi terhadap disiplin kerja pegawai. Penelitian ini menggunakan pendekatan kuantitatif dengan metode korelasional. Populasi penelitian ini adalah karyawan PT. Pelabuhan Pelabuhan Indonesia III (Persero) Cabang Tanjung Emas Semarang. Sampel diambil dengan menggunakan teknik simple random sampling sebanyak 104 responden. Metode pengumpulan data menggunakan metode kuesioner. Hasil penelitian ini adalah sebagai berikut: (1) terdapat pengaruh positif dan signifikan motivasi terhadap disiplin kerja dengan nilai thitung (3,286) > ttabel (1,983); (2) terdapat pengaruh positif dan signifikan komunikasi terhadap disiplin kerja dengan nilai thitung (3,893) > ttabel (1,983); (3) terdapat pengaruh positif dan signifikan supervisi terhadap disiplin kerja dengan nilai thitung (3,908) > ttabel (1,983); dan (4) Terdapat pengaruh positif dan signifikan motivasi, komunikasi, dan supervisi secara bersama-sama atau simultan terhadap disiplin kerja dengan nilai Fhitung (58,035) > Ftabel (2,70).

Kata Kunci: koneksi; semangat; supervisi; kepatuhan kerja

Abstract: This study aims to determine (1) whether motivation has an influence on employee work discipline. (2) whether there is an influence of communication on employee work discipline. (3) whether or not there is an influence of supervision on employee work discipline. (4) whether there is an influence of motivation, communication, and supervision on employee work discipline. This study uses a quantitative approach with the correlation method. The population of this study was made up of employees of PT. Port Pelabuhan Indonesia III (Persero) Tanjung Emas Semarang Branch. Samples were taken using a simple random sampling technique from as many as 104 respondents. Methods of data collection using the questionnaire method. The results of this study are as follows: (1) there is a positive and significant effect of motivation on work discipline with the value of tcount (3,286) > ttable (1,983); (2) there is a positive and significant effect of communication on work discipline with the value of tcount (3,893) > ttable (1,983); (3) there is a positive and significant effect of supervision on work discipline with the value of tcount (3,908) > ttable (1,983); and (4) There is a positive and significant effect of motivation, communication, and supervision together or simultaneously on work discipline with the value of Fcount (58.035) > Ftable (2,70).

Keywords: connection; motivation; supervision; work obedience
Peningkatan keterampilan public speaking melalui metode Monroe’s Motivated Sequence kelas XI OTKP SMKN 1 Surakarta
Authors: Wulandari Agustina Dewi , Murtini Wiedy , Subarno Anton
Published: June 2024

The purpose of this study was to find out: 1) how the teaching pattern of office administration teachers on PKWU subjects has changed in the new normal era, starting from the preparation to the evaluation process at SMKN 1 Banyudono; and 2) the obstacles found in learning at SMKN 1 Banyudono. The PKWU learning process in the new normal period was applied face-to-face, limited to face-to-face at SMKN 1 Banyudono; and 3) the efforts made to overcome the obstacles in the application of face-to-face were limited to PKWU subjects at SMKN 1 Banyudono. This type of research is descriptive-qualitative with a case study approach. The research was conducted at SMKN 1 Banyudono. Research data was obtained from informants, events, and documents with purposive and snowball sampling. Data collection techniques include observation, interviews, and documents. The validity of the data was obtained in four ways: credibility, transferability, dependability, and confirmability. The data analysis technique used interactive model data analysis with the following stages: 1) data collection, 2) data concession, 3) data presentation, and 4) drawing conclusions. The results showed that the teacher had carried out PKWU learning quite well in accordance with the official instructions.
Pengelolaan arsip di Kantor Badan Penyelenggara Jaminan Sosial Kesehatan Surakarta
Authors: Salsabila Haniyah , Sulistyaningrum Cicilia Dyah , Umam Muhammad Choerul
Published: June 2024

This study aims to determine the management of records, obstacles, and solutions applied to overcome these obstacles. This research was structured using a descriptive qualitative approach with a case study type; the sampling techniques used were purposive sampling and snowball sampling. Data was collected by interview, observation, document analysis, and literature study. The data were analyzed using interactive data analysis techniques and proved their validity through source triangulation and technical triangulation. The results showed that the management of archives at Badan Penyelenggara Jaminan Sosial Kesehatan Surakarta is still done manually, where the activities of creating, storing, moving, maintaining, shrinking, and destroying archives are carried out directly. In practice, there are several obstacles experienced, namely that the number of archives managed is very large. but there is no special room for storing archives, there are no employees who have special qualifications in the field of archive management, and the infrastructure that is owned is not complete enough; there are several cabinets, filing racks, and archive boxes. Efforts are being made to overcome these obstacles, among others, by transferring archived media, recruiting employees, and collaborating with third parties.
Pengaruh pembelajaran micro teaching dan efikasi diri terhadap minat menjadi guru mahasiswa FKIP UNS
Authors: Yunanto Ervin , Sawiji Hery , Winarno Winarno
Published: June 2024

The purpose of this study was to determine (1) the effect of micro-teaching learning on the intention to become a teacher, (2) the effect of self-efficacy on the intention to become a teacher, (3) the effect of microteaching learning and self-efficacy simultaneously on the interest in becoming a teacher in FKIP UNS students. This research is quantitative research with a survey method. The population in this study were FKIP UNS students, totaling 233 students. The sample in this study used proportionate stratified random sampling. The results of this study: (1) micro Teaching-learning has a positive and significant effect on the interest in becoming a teacher. This is evidenced by the value of count greater than ttable (6.277>1.976) and the significance value of (0.000<0.05). (2) Self-efficacy positively and significantly affects the interest in becoming a teacher. This is evidenced by the value of tcount greater than ttable (4.207>1.976) and the significance value of (0.000 <0.05). (3) There are dispositive and significant effects of micro-teaching and self-efficacy on the interest in becoming a teacher. This is evidenced by the value of count greater than ftable (27.014>3.78) and a significance value of (0.000<0.05). The results of the overall analysis in this study support the assumed hypothesis.
Pengaruh dimensi kualitas pelayanan publik pada bidang administrasi kependudukan terhadap kepuasan Masyarakat Jebres Kota Surakarta
Authors: Devitasari Intan , Ninghardjanti Patni , Winarno Winarno
Published: June 2024

The purpose of this study is to determine the effect of several dimensions as follows: (1) tangible,(2) responsiveness, (3) reliability, (4) assurance, (5) empathy, (6) all dimensions of service quality on the Jebres Surakarta Community Satisfaction. This research is categorized as the quantitative research method. The population in this study is the Jebres community, who have performed services. The sample in this study was 80 people. The research sampling technique used the Cluster Area Sampling. This research collected the data using questionnaires and used multiple linear regression techniques towards the IBM SPSS 26.0 program to analyze the data. The results showed that there was a positive and significant effect of: (1) the tangible evidenced by a significance value of 0.000 <0.05 and  3.792> a 1.992; (2) the responsiveness 0.000<0.05 and   5.338>  1.992; (3) the reliability of 0.018<0.05 and   2.426> a    1.992; (4) the guarantee value of 0.000 <0.05 and  of 5.170 >    1.992; (5) the empathy of 0.000 <0.05 and   of 7.017> a  1.992. (6) Simultaneously of dimension public service quality value of 0,000<0,05 and  95.900>  2,34. The results of this study show the double meaning of service quality to community satisfaction of 86.6%.
Pengaruh disiplin kerja dan motivasi kerja terhadap kinerja karyawan produksi di PT Djarum Kudus
Authors: Ristiyani Lutfi , Subarno Anton , Murwaningsih Tri
Published: June 2024

The purpose of this study is to determine (1) the effect of work discipline on employee performance, (2) the effect of work motivation on employee performance, and (3) the effect of work discipline and work motivation on employee performance. This study uses quantitative research with a population of 395 employees. The sample of this research used a simple random sampling technique with 80 samples. Data collection techniques were done by questionnaire. The data analysis technique used multiple linear regression analysis with the IBM SPSS 25 program. The results of this study stated that (1) there was a positive and significant effect of work discipline on employee performance (t=2.81, sign 0,01), (2) there was a positive and significant effect of work motivation on employee performance (t=3.17, sign 0.00) and (3) there was a positive and significant influence of work discipline and work motivation simultaneously on employee performance (t=73.48, sign 0.00).
Implementasi kurikulum merdeka di SMK Negeri 1 Karanganyar (studi kasus pada guru produktif)
Authors: Kusumaningrum Azizah Puji , Murwaningsih Tri , Indrawati Cicilia Dyah Sulistyaningrum
Published: June 2024

This study aims to determine (1) the Implementation of Kurikulum Merdeka in SMK Negeri 1 Karanganyar, and (2) the Obstacles and solutions experienced by productive teachers in SMK Negeri 1 Karanganyar. This research uses a qualitative method with a case study approach. Research data sources are obtained from informants, documents, and observations. The sampling technique uses purposive sampling and snowball sampling. Data collection techniques with interviews, observation, and document analysis. Data validity using triangulation of sources and techniques. The data analysis technique uses an interactive model. The results showed that: (1) Implementation of Kurikulum Merdeka is carried out in two stages, that is, (a) Planning includes the design of KOSP, design of ATP, planning of learning and assessment, use and development of teaching materials, planning of P5, (b) Implementation of learning includes implementation of P5, application of student-centered learning, integration of assessment in learning, learning according to the learning stages of students, collaboration between teachers for curriculum and learning purposes, collaboration with parents/families in learning, collaboration with the society/community/industry, reflection, evaluation, and improvement the quality of curriculum implementation. (2) The obstacles are: (a) Teachers have difficulty translating the Kurikulum Merdeka learning process, (b) Limitations of teaching tools used by teachers. The solutions are: (a) Attend education and training related to Kurikulum Merdeka, (b) Schools provide teaching tools supporting implementation.
Pengaruh persepsi mahasiswa tentang mata kuliah kewirausahaan dan kompetensi dosen terhadap minat berwirausaha mahasiswa
Authors: Puspitasari Lutfi Dwi , Ninghardjanti Patni , Subarno Anton
Published: June 2024

The purpose of this study was to determine: (1) the impact of student perceptions of entrepreneurship courses on the entrepreneurial intention of FKIP UNS students; (2) the impact of student perceptions of entrepreneurship lecturers' competence on the entrepreneurial intention of FKIP UNS students and (3) the impact of student perceptions of entrepreneurship courses and entrepreneurship lecturers' competence on entrepreneurial intention of FKIP students. This study uses quantitative methods. The study population was 2080 students of the FKIP Class of 2019. The sampling technique used proportional random sampling with 240 students as samples. The data collection method used a questionnaire. Data analysis uses multiple linear regression analysis with prerequisite analysis tests, namely normality, linearity, and multicollinearity tests. The results of the study are as follows: (1) there is a positive and significant influence between students' perceptions of entrepreneurship courses on entrepreneurial interest, as evidenced by tcount 9.50 > ttable 1.96; (2) there is a positive and significant influence between students' perceptions of lecturers' competence on entrepreneurial interest, as evidenced by tcount 2.35 > ttable 1.96; and (3) there is a significant influence between students' perceptions of entrepreneurship courses and lecturers' competence on entrepreneurial interest, as evidenced by Fcount 58.83 > Ftable 3.03.
Pengaruh persepsi promosi dan citra perusahaan terhadap loyalitas pelanggan aplikasi shopee
Authors: Putri Dias Murtika , Murtini Wiedy , Ninghardjanti Patni
Published: June 2024

Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh (1) promosi terhadap loyalitas pelanggan aplikasi Shopee, (2) citra perusahaan terhadap loyalitas pelanggan aplikasi Shopee (3) promosi dan citra perusahaan secara bersama-sama terhadap loyalitas pelanggan aplikasi Shopee. Penelitian ini merupakan penelitian kuantitatif dengan metode korelasional. Jumlah populasi sebanyak 339 mahasiswa PAP dan 100 mahasiswa diambil sebagai sampel. Sampel pada penelitian ini diambil menggunakan metode purposive sampling. Data penelitian dikumpulkan dengan kuesioner penelitian menggunakan skala likert 1-4 dan dianalisis dengan bantuan aplikasi SPSS versi 26. Hasil penelitian menunjukkan bahwa (1) terdapat pengaruh positif dan signifikan variabel promosi terhadap loyalitas mahasiswa pada aplikasi Shopee, dibuktikan dengan nilai signifikan sebesar 0,000 < 0,05 dan nilai thitung 4,318 > ttabel 1,984 (2) terdapat pengaruh positif dan signifikan variabel citra perusahaan terhadap loyalitas mahasiswa pada aplikasi Shopee, dibuktikan dengan nilai signifikan sebesar 0,037 < 0,05 dan nilai thitung 2,113 > ttabel 1,984 (3) terdapat pengaruh positif dan signifikan variabel promosi dan citra perusahaan secara bersama-sama terhadap loyalitas mahasiswa pada aplikasi Shopee, dibuktikan dengan nilai signifikan sebesar 0,000 < 0,05 dan nilai Fhitung 37,364 > Ftabel 3,09.

Keywords : citra perusahaan; beriklan; dedikasi pelanggan; kuantitatif

 

Abstract: This study aims to determine the effect of (1) promotion on customer loyalty in the Shopee application (2) corporate image on customer loyalty in the Shopee application (3) promotion and corporate image simultaneously on customer loyalty in the Shopee application. The total population is 339 students of PAP and 100 students are taken as samples. This research is quantitative research with a correlational method. The sample was taken using the purposive sampling method. The research data was collected using a research questionnaire with a Likert scale of 1-4 and analyzed using the SPSS version 26 application. The results showed that (1) there is a positive and significant effect of the promotion on customer loyalty of students in the Shopee application, as evidenced by a significant value of 0,000 < 0,05 and tcount value of 4,318 >tcount 1,984 (2) there is a positive and significant effect of corporate image on customer loyalty of students in Shopee application, as evidence by the significant value of 0,037 < 0,05 and tcount value of 2,113 >tcount 1,984 (3) there is a positive and significant effect of promotion and corporate image simultaneously on customer loyalty of students in Shopee application, as evidence by the significant value of 0,000 < 0,05 and Fvalue 37,364 > Ftable 3,09.

Keywords:  advertise; corporate image; customer dedication; quantitative
Seamless Solar-Powered Hydroponics Revolutionizes Urban Farming in Indonesia
Authors: Muchtarom Alfin , Jamaluddin Jamaluddin
Published: June 2024

This study explores the use of PLTS (solar power) as an alternative energy source for urban hydroponic systems. Due to PLTS's limited capacity, an automatic transfer switch (ATS) is utilized to seamlessly switch between PLTS and PLN (public electricity) based on sensor readings. The system uses an INA219 sensor to monitor PLTS voltage, a TDS sensor for water quality, and a NodeMCU microcontroller, with data displayed on an LCD and Blynk for remote monitoring. Testing showed a PLTS voltage of 12.0V, with sensor accuracies of 96% (INA219) and 98.59% (TDS). Overall, the system demonstrated reliable and optimal performance, providing a sustainable solution for urban hydroponic farming. Highlights: 1. PLTS and PLN integration ensures reliable power for urban hydroponics.2. High sensor accuracy supports precise system monitoring.3. Remote monitoring via LCD and Blynk enhances control and sustainability. Keywords: PLTS, hydroponic systems, automatic transfer switch, NodeMCU, sustainability
Unveiling Key Factors for Enhanced Employee Performance in Indonesia
Authors: Yoshanda Agung Andana , Sulistiyowati Wiwik
Published: June 2024

This study investigates the impact of employee competence and the work environment on performance at PT. Karya Mitra Teknik Forklift Sidoarjo. Through observations, interviews, and surveys with 30 employees over six months, the study applies Partial Least Squares Structural Equation Modeling (PLS-SEM) and Importance Performance Analysis (IPA). Results show that both competence and the work environment significantly influence performance, with timely task completion and a supportive work environment identified as key areas for improvement. Enhancing employee discipline and optimizing workplace conditions are recommended to boost productivity and employee satisfaction in heavy equipment service companies. Further research could explore additional factors like compensation to further enhance organizational outcomes. Highlight:  Investigate competence and environment effect on employee performance. Timely task completion and supportive work environment enhance performance. Improve employee discipline and optimize workplace conditions for effectiveness.   Keywoard: Competence, Work Environment, Performance, Heavy Equipment Services, Employee Satisfaction
The mechanism of recrystallization of binary aluminum and tin bronzes
Authors: Marukovich E. I. , Stetsenko V. Yu. , Stetsenko A. V.
Published: June 2024

A nanostructural mechanism for recrystallization of binary aluminum and tin bronzes has been developed. First, structure-forming nanocrystals of α-phases, β-phases and γ-phases are formed from elementary nanocrystals of copper, aluminum, tin and their free atoms. The crystallization centers of microcrystals of phases are formed from them. From these centers, structure-forming nanocrystals of phases, free atoms of copper, aluminum, tin, microcrystals of α-phases, β-phases and γ-phases of binary aluminum and tin bronzes are formed.
A phase 3 randomised double-blind placebo-controlled trial of mirtazapine as a pharmacotherapy for methamphetamine use disorder: A study protocol for the Tina Trial
Authors: McKetin Rebecca , Degan Tayla , Saunders Lucy , Nguyen Long , Dore Gregory , Shoptaw Steven , Farrell Michael , Degenhardt Louisa , Kelly Peter J , Turner Alyna , Clare Philip J , Dean Olivia M , Arunogiri Shalini , Colledge-Frisby Samantha , Koeijers Juanita , Goodman-Meza David , Sinclair Barbara , Reid David , Hill Harry , Hayllar Jeremy , Christmass Michael , Cordaro Frank , Lundin Robert , Liaw Willy , Liu Danica , Holyoak Ellie , Wu Brian Tid-Fung , Kegan Joel , Kontogiannis Ava , Palmer Lily , Morrison Caity , Wrobel Anna , Hyland Rebecca , Byrne Marianne , Zahra Emma , Russell Samantha , Berk Michael
Published: June 2024

Background
There are no approved pharmacotherapies for methamphetamine use disorder. Two preliminary phase 2 randomised controlled trials have found mirtazapine, a tetracyclic antidepressant, to be effective in reducing methamphetamine use. The proposed Tina Trial is the first phase 3 placebo controlled randomised trial to examine the effectiveness and safety of mirtazapine as an outpatient pharmacotherapy for methamphetamine use disorder.
Methods
This is a multi-site phase 3 randomised, double-blind, placebo-controlled parallel trial. Participants are randomly allocated (1:1) to receive either mirtazapine (30 mg/day for 12 weeks) or matched placebo, delivered as a take-home medication. The target population is 340 people aged 18–65 years who have moderate to severe methamphetamine use disorder. The trial is being conducted through outpatient alcohol and other drug treatment clinics in Australia. The primary outcome is measured as self-reported days of methamphetamine use in the past 4 weeks at week 12. Secondary outcomes are methamphetamine negative oral fluid samples, depressive symptoms, sleep quality, HIV risk behaviour and quality of life. Other outcomes include safety (adverse events), tolerability, and health service use. Medication adherence is being monitored using MEMS® Smart Caps fitted to medication bottles.
Discussion
This trial will provide information on the safety and effectiveness of mirtazapine as a pharmacotherapy for methamphetamine use disorder when delivered as an outpatient medication in routine clinical practice. If found to be safe and effective, this trial will support an application for methamphetamine use disorder to be included as a therapeutic indication for the prescription of mirtazapine.
Trial Registration:
Australian and New Zealand Clinical Trials Registry (ACTRN12622000235707). Registered on February 9, 2022.
Ceftazidime-Avibactam Use in Carbapenem-resistant Klebsiella pneumoniae Bloodstream Infections: A Retrospective Observational Multicenter Study in OXA-48 Endemic settings
Authors: Mert Ali , Derin Okan , Akalın Halis , Dumlu Rıdvan , Gündeş Sibel , Zengin Rehile , Kocagöz Sesin , Gündoğdu Yasemin , Köksal İftihar , Yalçın Demet , Üstün Cemal , Kapmaz Mahir , Görenek Levent , Karahangil Kadriye , Can Füsun , Ergönül Önder , Concortia Concortia
Published: June 2024

Background.
Experience of ceftazidime-avibactam (CAZ-AVI) use in OXA-48 producing K. pneumoniae bloodstream infections (OXA-48-Kp BSIs) is limited. We aimed to describe the clinical outcomes of OXA-48-Kp BSIs treated with CAZ-AVI in hospital settings, where OXA-48-producing K. pneumoniae is endemic.
Methods.
A multicenter retrospective observational study was conducted between January 2017 and September 2021. The aim of the study is to describe the clinical data that affects outcome, the 30-day mortality and relapse. The predictors of 30-day mortality are detected by using cox regression model.
Results.
We included 106 adults with CAZ-AVI-susceptible, carbapenem-resistant K. pneumoniae (CR-Kp) BSIs who received at least 72 hours of CAZ-AVI therapy. Mortality was found to be lower in those who started CAZ-AVI from the initial treatment compared to those who switched from colistin-based-regimen to CAZ-AVI[14.3% (n = 3/21) vs 37.7%(n = 32/85), p = 0.04].In multivariate analysis older age, having severe neutropenia were found to be significantly associated with the higher rate of mortality. Same-day CAZ-AVI start lowers mortality risk significantly.(HR:0.25, CI: 0.07–0.84, p = 0.025).
Conclusions.
Data of our cohort showed that CAZ-AVI monotherapy is an important treatment option in OXA-48-Kp BSIs. In addition, the study confirmed that early initiation of CAZ-AVI is more appropriate than switch to CAZ-AVI from a colistin-based-regimen.
Assessment of Heavy Metal Contamination in Offshore and Inshore Sediments of The Arabian Gulf
Authors: Alharbi Khaild N. , Almalki Majed A. , Almotairy Hany M. , Alotaibi Mohammed F. , Alharbi Khaled S. , Alqahtani Sarah H. , Aleid Musaad K. , Alfaifi Hassan Y. , Almoiqli Mohammed S. , Alhadadi Abdulrahman H. , Bin-Suliman Asim , Albaiji Ahmed , Alhafedh Yousef , Alnasser Ibrahim , Albarqi Mubarak M. , Alsulami Raed A. , Abo-Alhannod Omar , Alzahrani Ekab S.
Published: June 2024

The study focuses on evaluating the presence of heavy metals in sediments samples from the Arabian Gulf, collected in December 2023. Utilizing inductively Coupled Plasma Mass Spectrometry (ICP-MS, the concentrations of various heavy metals were determined. Notably, the average concentration of iron (Fe) exceeds 5000 mg/kg. Other metals such as chromium (Cr), cobalt (Co), nickel (Ni), copper (Cu), and zinc (Zn) exhibit concentrations within acceptable limits. However, arsenic (As) concentration averages around 22 mg/kg. Moreover, concentrations of silver (Ag) and cadmium (Cd) slightly exceed the recommended levels.
Factors Influencing the Improvement of Environmental Health Literacy in Shanghai Residents: Three Rounds of Cross-sectional Studies from 2020 to 2022
Authors: Han Fengchan , Tong Ling , Qian Hailei , Shi Yewen , Zhang Jiang hua , Dong Chunyang , Wang Duo , Chen Feier , Wu Chen , Xu Mingjing , Liu Yongping , Su Jin , Xu Huihui , He Yi , Chen Tian , Shaofeng Sui
Published: June 2024

Background
In 2019, the Chinese State Council issued the "Healthy China Initiative (2019–2030)", in which the section of " Action for the promotion of a Healthy Environment " explicitly calls for the levels of environmental and health literacy (EHL) of the residents to reach more than 15% and 25% in 2022 and 2030, respectively.
Objective
In order to identify weaknesses in the popularization of environmental health knowledge and make targeted improvements, Shanghai has conducted three rounds of environmental health literacy (EHL) surveys from 2020 to 2022.
Methods
Multi-stage random sampling method was used in the three rounds of cross-sectional studies. A total of 8348 valid participants aged from 15 to 69 were assessed by The Core Questionnaire for Assessing the EHL of Chinese residents (Trial Implementation). Factors influencing EHL levels were analyzed using χ 2-test, Kruskal-Wallis test, generalized linear model (GLM), and multivariate logistic regression.
Results
The mean score of EHL for all participants was (58.93 ± 16.35) points, which was below the reference value of 70 points. Compared with the first round of the survey in 2020 (55.28 ± 15.64 points), the scores were significantly promoted (P < 0.001) in 2021 and 2022, with (61.77 ± 15.92 points) and (62.13 ± 17.14 points), respectively. The results showed that the EHL significantly increased from 18.74% in 2020 to 33.22% in 2022. The generalized linear model suggested that survey year, residential area, education level, occupation and income were also influential factors of EHL. For educational attainment, the largest increase of 11.937 points was observed in the postgraduate and above group compared with the control group (primary school and below). The results of the multivariate logistic regression model were consistent with those of GLM: residents had higher EHL in the groups of third round survey [OR: 2.71, 95%CI: 2.23–3.13], high education [OR: 3.73, 95%CI: 2.40–5.86], high income [OR: 1.61, 95%CI: 1.26–2.06], and student occupation [OR: 3.09, 95%CI: 2.06–4.65].
Conclusions
Education attainment was a crucial factor influencing the EHL of Shanghai residents. The popularization and promotion of environmental health knowledge can significantly improve the EHL of Shanghai residents.
Durable All Inorganic Perovskite Tandem Photovoltaics
Authors: Yan Keyou , Duan Chenghao , Zhang Kaicheng , Peng Zijian , Li Shiang , Zou Feilin , Wang Feng , Li Jiong , Zhang Zheng , Chen Chang , Zhu Qiliang , Qiu Jianhang , Lu Xinhui , Li Ning , Ding Liming , Brabec Christoph , Gao Feng
Published: June 2024

Inorganic perovskite tandem solar cells (IPTSCs) are promising candidates to break the efficiency bottleneck and address the stability issue. However, challenges remain in fabricating 2-terminal (2T) IPTSCs due to the inferior film formation and deep trap states induced by tin cations. Herein, a green ligand evolution (GLE) strategy with p-toluenesulfonyl hydrazide is employed to regulate film formation and eliminate deep traps in inorganic narrow bandgap perovskite, enabling the successful development of 2T IPTSCs. Accordingly, the 1.31 eV CsPb0.4Sn0.6I3:GLE device delivers a record efficiency of 17.41%. Combined with the 1.92 eV CsPbI2Br top-cell, 2T-IPTSCs exhibit a champion efficiency of 22.57% (certified 21.92%). Additionally, IPTSCs are engineered to deliver remarkable operation durability under maximum power point tracking, maintaining 80% of the initial efficiency at 65 ℃ for 1510 h and 85℃ for 800 h, respectively.
Serum metabolite changes are implicated in high-altitude acclimatization and de-acclimatization
Authors: Wei Wenxiang , Liu Xiaoyan , Yang Wei , Li Qiuli , Cai Mingjing , Dai Wenjing , Zhang Haifeng , Xing Wenjuan , Ma Lijie
Published: June 2024

For individuals from lowland areas traveling to high-altitude regions, acclimatization and de-acclimatization (ADA) to high altitudes is an inevitable physiological process, accompanied by complex metabolic adjustments. In this study, we investigated 18 subjects (nine males and nine females) who traveled to and remained at an altitude of 4200 m for 3 months. We used untargeted metabolomics to analyze serum metabolomic changes after this period and then at specific time points after their return to the plains. We observed considerable differential serum metabolite expression at T1 (after the 3 month-high-altitude stay), T2 (day 2 after returning to the plains), and T3 (day 30 after returning to the plains). Gender differences and initial high-altitude response levels also affected metabolite changes. Metabolite-related signaling pathway analyses showed that the most significant differential metabolic pathways at T1 and T2 were pentose phosphate pathway (PPP), butanoate metabolism, arginine biosynthesis, and glucagon signaling pathways. The most significant differential metabolic pathways at T1 and T3 were galactose metabolism, arginine biosynthesis, sphingolipid signaling pathway, ATP-binding cassette (ABC) transporter, and biosynthesis of unsaturated fatty acid (FA) pathways. The most significant differential metabolic pathways between males and females at T1 were ABC transporter, purine metabolism (PM), central carbon metabolism in cancer (CCMiC), ascorbate and aldarate metabolism (AAM), and valine, leucine, and isoleucine biosynthesis pathways. Thus, during ADA to high altitudes, ABC transporter, PP, pentose and glucuronate interconversion (PGI), and PM signaling pathways had important roles. Our data provide new insights into the metabolic changes during ADA to high altitudes.
Is Tanzania Freewill Prevention A Response Enough? Reflecting Market Vendors Adherence to Covid-19 Infection Prevention Control Measures in Morogoro Municipal
Authors: Ndeki Douglas G. , Anaseli Mackfallen
Published: June 2024

BACKGROUND
The purpose of this evaluation study was to assess the status of adherence of IPC measures among market vendors in Morogoro Municipal. Specifically, the study aimed to examine IPC measure implemented, the proportion of market vendors’ adherence to IPC measures, factors influencing adherence of IPC among market vendors and perception of market vendors on COVID-19 prevention measures.
METHODS
We employed a cross- sectional study to 525 respondents, where 524 were market vendors and 1 respondent was from Morogoro Municipal Health authority. We deployed sequential mixed methods to the study including questionnaires (quantitative), interviews and unstructured observations (qualitative). We used descriptive statistics to summarize socio - demographic characteristics and Multivariate Logistic regression model to analyze factors influencing adherence of COVID-19.
RESULTS
81.1% of market vendors adhere to IPC measure. However, there were difference in adherence across groups by education 43%. Hand hygiene was the common practiced IPC measure (60.1%), whereas the least practiced measure was mask wearing (10.5%). Age, education level, residence, knowledge on isolation period and previous experience with someone with COVID-19 had influence to adherence of COVID-19 prevention measures by significance value (P < 0.05).
CONCLUSION
Adherence status of market vendors to COVID-19 IPC measures is satisfying. The study recommends improved behavioral change measures such as education in rural areas as it was in urban areas and an increased budget on emergency preparedness.
Identification and validation of disulfidptosis-related signature to evaluate clinical outcomes, immune infiltration and drug sensitivity in osteosarcoma
Authors: Zhao Yonghui , Su Xiaochen , Teng Menghao , Ru Hao , lu Ziliang , Zhang Yulong , Zhang Yilei , Zhang Yingang
Published: June 2024

Disulfidptosis is a novel form of programmed cell death discovered by Liu et al. It's initiated in cells highly expressing SLC7A11, especially in cancers. Our principal aim is to establish and validate a prognostic prediction model for osteosarcoma patients, potentially providing a fresh perspective on the characteristics of disulfidptosis in osteosarcoma and its treatment. Osteosarcoma cohorts obtained from the TARGET and GEO databases were classified into disulfidptosis-high/low-related groups to analyze the Differentially Expressed Genes (DEGs) using the ssGSEA method. DEGs were subsequently analyzed by the Weighted Gene Co-expression Network Analysis (WGCNA) method. Various machine learning algorithms, including the log-rank test, univariate Cox analysis, and LASSO algorithm, were employed, yielding 5 Disulfidptosis-Related Genes (DRGs). GSVA and ssGSEA, were also conducted to investigate the underlying mechanisms of disulfidptosis in osteosarcoma. We established a reliable disulfidptosis-related classification, aand our subsequent analysis has suggested intriguing disparities in the expression of the pentose phosphate pathway (PPP) and cytoskeleton regulation among the groups, indicating that the high-related group was more susceptible to disulfidptosis. 5 disulfidptosis-related genes were selected from the differentially expressed genes (DEGs) , and samples in the cohorts were divided into high-/low-risk groups based on the risk score. Functional analysis demonstrated significantly higher expression of the regulation of the cytoskeleton pathway in the high-risk group. Additionally, immune cell-associated pathways such as the T cell receptor signaling pathway and NOD/TOLL-like receptor signaling pathway showed significant decreases in the high-risk group. We then analyzed the infiltration of immune cells in the tumor microenvironment, revealing lower infiltration of almost every immune cell in the high-risk group. To gain insights into the clinical treatment of osteosarcoma patients, we also analyzed the differences in drug sensitivity between the risk groups, identifying 8 drugs that were more sensitive in the high-risk group.
Anomalous systemic artery supply to the left basal lung with arterial dissection of the feeding artery: a case report and literature review
Authors: Ma Luping , Xia Ruiming , Yu Zhongqiang , Wang Liang , Hu Wenbin , Yao Kelin
Published: June 2024

Anomalous systemic arterial supply to the left basal lung is a rare congenital abnormality and is even rarer when associated with arterial dissection of the feeding artery. Herein, we report a young patient who was hospitalized with sudden chest pain, which proved to be an abnormal thoracic aorta supplying blood to the basal segment of the left inferior lobe of the lung, with the supply artery dissection. It hasn't been reported as far as we know. The patient was successfully surgically resected and recovered well at follow-up.
Impact of Desmopressin on Clinical Outcomes in Patients with Spontaneous Antiplatelet-Associated Intracerebral Hemorrhage Undergoing Neurosurgical Intervention: An Observational Multi-Center Study
Authors: Hsu Pang-Ting , Shuo-Chi Chien , Chen Ching-Chang , Liu Zhuo-Hao , Chuang Chi-Cheng , Tsai Yu-Chen , Chaou Chung-Hsien , Yen Chieh-Ching
Published: June 2024

Objective:
Managing surgical cases of acute spontaneous intracerebral hemorrhage (ICH) in patients with antiplatelet therapy presents significant challenges due to the heightened risk of bleeding. Desmopressin acetate (DDAVP) is commonly employed as a management strategy. This multi-center study aims to compare the functional and safety outcomes in patients with or without preoperative DDAVP administration after spontaneous antiplatelet-associated ICH.
Methods:
From January 2016 to November 2023, we enrolled patients with spontaneous ICH who were under antiplatelet therapy and needed neurosurgical interventions in the emergency departments. Patients were excluded for traumatic brain injury, ICH from subarachnoid hemorrhage, arteriovenous malformation, intracranial tumors, coagulopathies, and anticoagulant use. The primary outcome was the modified Rankin Scale (mRS) at discharge. Secondary endpoints included safety outcomes, in-hospital and follow-up outcomes.
Results:
A total of 75 patients were included, comprising 26 patients treated with DDAVP and 49 patients in the control group. After inverse probability of treatment weighting adjustment, there were no significant differences in baseline characteristics except for preoperative platelet transfusion between the DDAVP and control group (73.6% vs 33.6%; p = 0.007). There were no significant differences in mRS of 4 – 6 at discharge between groups (77.4% vs 85.1%; p = 0.533). Multivariable generalized estimating equations logistic regression demonstrated DDAVP was not significantly associated with improved functional outcome, safety outcomes, in-hospital or follow-up outcomes.
Conclusion:
This study demonstrated that there was no significant difference in mRS at discharge or SAEs between patients with and without DDAVP administration. Further randomized controlled trials are warranted to validate our findings.
Influencing factors of work engagement among ophthalmic specialized nurses in China: a cross-sectional study
Authors: Ren Jie , Zhang Xin , Gao Yun-Xia
Published: June 2024

Aim: This study aims to investigate the current status of work engagement among ophthalmic specialized nurses in China and explore the multifaceted factors influencing work engagement from the physical, psychological, and social perspectives.
Methods：This study adopts a cross-sectional survey design, distributed electronic questionnaires through WeChat software, and 261 valid questionnaires were received from ophthalmic specialized nurses. The survey includes demographic information about ophthalmic specialized nurses, as well as work engagement, sleep quality and social support. A generalized linear model was used to investigate the factors influencing the work engagement of ophthalmic specialized nurses.
Results: The overall work engagement score among ophthalmic specialized nurses in our study was 143.70±13.66. Multivariate analysis showed that participation in teaching, professional title, sleep quality and perceived social support were the influencing factors of work engagement of ophthalmic specialized nurses.
Conclusion: Ophthalmic specialist nurses in China demonstrate a relatively high level of work engagement. Those with the title of senior nurse, involvement in teaching, better sleep quality, and higher perceived social support exhibit higher work engagement.
Impact of caudate lobe resection on overall survival and liver disease-free survival in colorectal liver metastases: A pilot study
Authors: Gul Melih Can , Demirel Emin
Published: June 2024

BACKGROUND
This study aimed to evaluate the management of colorectal liver metastases (CRLM) and the role of anatomical resections, with particular reference to the caudate lobe.
METHODS
We obtained all patient data from the Preoperative CT and Survival Data for Patients Undergoing Resection of Colorectal Liver Metastases dataset. Patients who underwent total caudate lobe resection without radiological evidence of metastases were analyzed. To investigate the net effect of caudate lobe resection, propensity score matching (PSM) was applied to most other parameters. The Kaplan-Meier and log-rank tests were used to calculate overall survival (OS) and liver disease-free survival (liver-DFS) and to investigate differences between groups.
RESULTS
Patients who underwent total caudate resection had better results in terms of overall survival in the whole data set and after PSM (respectively, p < 0.001 HR: 0.43, 95%CI:0.26–0.72 p:0.024, HR: 0.65 95%CI:0.59–0.79).Patients who underwent total caudate resection had better results in terms of liver-DFS in the whole data set set and after PSM (respectively, p = 0.014, HR = 0.46, 95%CI: 0.24–0.85, p = 0.026 HR = 0.5, 95%CI: 0.37–0.79)
CONCLUSİONS
We believe that the addition of total caudate lobe resection to resection may contribute to both OS and liver DFS.
Efficacy of neoadjuvant chemotherapy combined with prophylactic intraperitoneal hyperthermic chemotherapy for patients diagnosed with clinical T4 gastric cancer who underwent laparoscopic radical gastrectomy: a retrospective cohort study based on propensity score matching
Authors: Lv Chenbin , Tong Lin-Yan , Zeng Wei-Ming , Chen Qiu-Xian , Fang Shun-Yong , Sun Yu-Qin , Cai Li-Sheng
Published: June 2024

Background
Clinical T4 (cT4) stage gastric cancer presents with frequent postoperative recurrence and poor prognosis. This study is to evaluate the oncological efficacy of laparoscopic radical total gastrectomy combined with postoperative prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with cT4N + M0 gastric cancer who received neoadjuvant chemotherapy.
Methods
We reviewed the clinicopathological data of 174 patients with clinical T4 gastric cancer who underwent neoadjuvant chemotherapy followed by laparoscopic radical total gastrectomy between June 2017 and December 2021. Among them, 142 were included in the non-HIPEC group, and 32 in the HIPEC group. Patients in both groups were paired based on propensity score in a 2:1 ratio to assess disparities in tumor recurrence and long-term survival.
Results
After matching, there were no significant differences in the clinicopathological data between the two groups. The peritoneum (16.1%) and distant organs (10.9%) were the most frequent locations for recurrence. Prior to matching, the recurrence rates were similar at all sites for both groups. Compared with those in the non-HIPEC cohort, the recurrence rates at all sites, the lung, and the peritoneum were notably lower in the HIPEC cohort. Prior to matching, the 3-year overall survival and disease-free survival rates were similar between the two groups; following matching, the HIPEC group exhibited notably greater survival rates than did the non-HIPEC group. The disparities in survival rates between the groups became even more pronounced after conducting a stratified analysis among patients with stage III disease.
Conclusions
Neoadjuvant chemotherapy combined with prophylactic HIPEC after laparoscopic radical gastrectomy can effectively reduce the rate of peritoneal metastasis in patients with cT4N + M0 advanced gastric cancer and significantly improve the prognosis of such patients, which is of great clinical value.