bluuebunny/crossref_metadata_2025 huggingface dataset:
PROTRUSION TRANS-ANALE DU CATHETER D’UN SHUNT VENTRICULOPERITONEAL CHEZ UN ENFANT : RAPPORT DE CAS ET REVUE DE LA LITTERATURE

TRANS-ANAL PROTRUSION OF THE CATHETER OF A VENTRICULOPERITONEAL SHUNT IN A CHILD: CASE REPORT AND REVIEW OF THE LITERATURE
Authors: Romli Oualid , Himmiche Meryem , Idodane Mohsine , Aggouri Mohamed
Published: October 2024

Abstract
The ventriculoperitoneal shunt (VPS) is a technique of choice for the treatment of hydrocephalus in children. Perforation of the sigmoid colon and trans-anal protrusion of the ventriculoperitoneal shunt catheter is one of the rare complications of VPS. The purpose of this article is to report a case of intestinal perforation with protrusion of the distal catheter of a VPS. This is an 18-month-old infant who was operated on for VPS 10 months ago. He is admitted to the emergency departments for an externalization of catheter through the anus. The clinical examination shows an afebrile child without meningeal signs. Under a normal laboratory assessment, the patient was operated for a change of the intraperitoneal drain and closure of the intestinal entrance orifice. The biological and clinical course was marked by septic shock that did not respond to resuscitation measures. The patient admitted under a negative infectious assessment, progresses to a febrile state at 38.5 °C and a positive infectious balance (C-reactive at 210 mg/l and hyperleukocytosis at 37,000 units/mm3). Bacteriological culture of cerebrospinal fluid allowed antibiotic therapy targeting Staphylococcus aureus. However, the evolution marked by the persistence of complications, leads to the death of the patient on the twentieth day in a table of refractory multiple organ failure.
The Role of Pilocarpine Eye Drops in the Management of Presbyopia: A Systematic Review
Authors: Abbas Khaldon , Gill Karanvir , Gajiwala Pratik , Abbas Ahmed , Alenazi Mohammed , Koaik Mona
Published: October 2024

Introduction:
Presbyopia is characterized by progressive loss of accommodation resulting in loss of visual acuity and is known to affect quality of life. Mainstay treatment include reading spectacles, contact lenses, and a series of surgical techniques. Until recently, pharmacologic treatment have been available. In this paper, we aim to review the role of pilocarpine eye drops in managing presbyopia.

Methods:
A comprehensive literature search was performed using Medline, EMBASE, and grey literature databases for articles from inception until 06 June 2024. Search terms included “presbyopia”, “presbyopia correction/treatment”, “pilocarpine”, and “pharmacological presbyopia treatment”. All relevant articles examining the efficacy and side effects of pilocarpine formulations and written in the English language were included in the review.

Results:
The initial search yielded 587 publications, of which 19 met our inclusion criteria and were included in analysis. Pilocarpine, a parasympathomimetic drug, increases the power of accommodation by increasing the lens thickness via the muscarinic receptors on the iris and ciliary muscles. Clinical trials utilizing pilocarpine eye drops in the management of presbyopia have reported positive outcomes in terms of near visual acuity. Pilocarpine HCL ophthalmic 1.25% formulation; Vuity™ and 0.4% formulation, Qlosi™ are currently the only approved pharmacologic treatment options shown to be effective in managing presbyopia.

Conclusion:
Overall, pilocarpine eye drops appear to be an effective option in improving near visual acuity in presbyopia patients. Long term follow-up data on the use of pilocarpine-based eye drops is not available. With the increase in the number of users overtime, the long-term effects of its prolonged use may be determined. Further research is needed to optimize the concentrations and combinations of pilocarpine and other substances to maximize efficacy and minimize adverse effects.
Atypical Eclampsia in a Patient with Multiple Social Determinants of Health: Insights into Prevention - A Case Report
Authors: Agbeve Shanon , Collazo Karla , Iribarren Mercy , Perez Alejandro , Perez Amalia , Salinger Daren
Published: October 2024

Eclampsia is a life-threatening condition that is often preceded by a preeclamptic diagnosis of hypertension and proteinuria after 20 weeks gestation. However, there is evidence to believe that eclampsia does not always follow this linear pattern giving rise to the term atypical preeclampsia-eclampsia. This aberrant presentation of eclampsia can lead to untimely diagnosis and can contribute to maternal mortality and morbidity. We report a rare case of a previously healthy 17-year-old primigravid at 40 weeks and 4 days gestation who developed a new onset generalized tonic-clonic seizure during Cesarean section delivery. The patient had been asymptomatic except for transient increased blood pressure during her hospital admission. Her risk factors for eclampsia included age less than 20 years-old, nulliparity, limited prenatal care, uninsured, and recent immigration status from Guatemala. Our aim is to increase awareness of puerperium atypical eclampsia in asymptomatic patients affected by multiple social determinants of health.
Systemic Interleukin-17 A and Transforming Growth Factor β1 in Acute Tonsillitis Patients
Authors: Ali Wurud , Alsultany Zahraa , shala Nawras , Gemeel Frial , Alsultany Shaimaa
Published: October 2024

The study aim to this research was to figure out what role regulatory cytokines that are a play in patients. suffer from acute tonsillitis disease.to analyses the level of production of cytokine Interleukiny17j andjtransformingjgrowthjfactorjbetaj1 (IL17A and TGF β1 )and c-reactive protein .This study included collected about 92 blood sample from the patients who were the suffering from acute tonsillitis disease and ten (10)control for both genera male and female with age the ranging from the 1-60 years admitted in Al_ Hillah teaching the hospital and the hospital Babylon for birth and children during the a period from November 2017 Marchyy2018 This study included studying of some immunological parameter such as Interleukiny17j(IL-17)andjtransformingjgrowthjfactorjbetaj1(TGF-β)andj CRP The CRP –latex particles are coated with antibodies to human CRP. The CRP latex reagent has been standardized to detect serum CRP level at or above 6 mg/L which is considered the lowest concentration of clinical significance When the latex suspension was mixed with serum containing elevated. The results of CRP in this study show that 37 sample was positive for CRP test and the titer of CRP was higher than normal range CRP titer >5CRP increases when there is inflammation throughout the body . results of CRP test in this study show that’s 38 sample were show positive to these test titer of this test >5 The concentration level of the IL-17jand TGF_βk (systemic )were determined by Enzyme Linked Immune sorbent Assay (Elisa)method . The concentration level of IL-17systemic molecule with mean value (746.40)pg./ml respectively while the control group with mean value (659.76)pg./ml. The concentration level of TGF_β systemic with the mean value is (63.2942)pg./ml respectively while the control group with the mean value (54.6214)pg./ml .
A new method of distracting attention: Is it effective for pain and fear during phlebotomy in children?
Authors: Sahin Mine , Cigerci Yeliz , Ozdemir Hamide
Published: October 2024

This study examined the impact of a novel distraction approach on the mitigation of fear and pain experienced by children between the ages of 7 and 12 during phlebotomy procedures. A total of 246 children who underwent phlebotomy between January and March 2019 in the pediatric blood collection unit were included in this randomized controlled trial. The participants (n = 246) were randomized to the intervention (n = 123) and control groups (n = 123). A musical blood collection tube was used in the intervention group. The Personal Information form, the Children's Fear Scale (CFS), and the Faces Pain Scale-Revised (FPS-R) were used for the collection of the data. Fear and pain were primary and secondary outcomes, respectively. A formal approval from the ethics committee was sought in order to proceed with the study. In this study, the CONSORT checklist was used as a guide and ethical principles were followed. The pain intensity and fear level of the children in the intervention group (CFS=1.73±1.07; FPS-R= 1.65±1.33) were lower than those in the control (CFS=2.86 ± 1.07; FPS-R= 3.09±1.57). The reduction in the intervention group's pain intensity and fear level differed significantly (p=0.000 and p=0.000, respectively). The results showed that using the musical blood collection tube as a new distraction technique reduces fear and pain intensity during phlebotomy in children. The musical blood collection tube can be used by health professionals as a non-pharmacological method to reduce the pain and fear of children during blood collection.
Etiological classification of high sedimentation rate and relation with other inflammatory markers
Authors: Temiz Sultan , Sagcan Baris , Tantekin Helin , Arslan Kadem
Published: October 2024

This study describes the causes of significantly increased erythrocyte sedimentation rate (ESR) and compares the etiological categories based on inflammatory markers. We collected data from the patients who applied between March 2020 and August 2023. Patients were categorized into five groups based on their identified etiology. Categories were sorted as infection, inflammatory, malignancy, renal, and others. Inflammation markers were compared between groups and ROC analysis was performed if there was a significant difference. The cause of the elevated ESR levels in 291 patients was determined. The median age was 58 (18-92). ESR levels were lower in females (113, 106-120) than in males (119, 109-120) (p=0.015). The distribution of etiological disease categories was as follows: inflammatory (41.9%), infection (35.1%), malignancy (18.2%), renal (3.1%), and others (1.7%). Albumin levels were lower in the malignancy group than in the inflammatory group (p<0.005). Platelet counts of the inflammatory group were higher than other groups (p=0.005). Neutrophil-lymphocyte ratio (NLR) was higher in the malignancy group than in the inflammatory group (p=0.001). Monocyte-lymphocyte ratio (MLR) was, NLPR, and SIRI were lower in the inflammatory group than others (p<0.001). ROC curves for inflammatory markers have been calculated. MLR had the highest area under the curve (AUC: 0.655, p<0.001), and the cut-off value of MLR which is 0.2775 had 65.3% sensitivity and 65.5% specificity to identify the cases without the inflammatory disease. This study presents the causes of significantly increased ESR and its correlation with inflammatory markers. We aim to highlight the differences between etiological groups using cost-effective and accessible blood test results.
Survival outcomes, low awareness, and the challenge of neglected leptospirosis in dogs
Authors: Tansakul Mookmanee , Sawangjai Pimkhwan , Bunsupawong Phassakorne , Ketkan Orapin , Thongdee Metawee , Chaichoen Kridsada , Sakcamduang Walasinee
Published: October 2024

Background:
Leptospirosis is a globally neglected zoonotic disease with significant morbidity and mortality in dogs, particularly in resource-limited settings.
Aim:
This study aimed to characterize prognostic factors and survival outcomes in dogs with suspected leptospirosis, emphasizing the potential underestimation of disease burden.
Methods:
This retrospective study was conducted using medical records of dogs diagnosed with urinary Leptospira polymerase chain reaction (PCR).
Results:
Urinary Leptospira PCR was positive in 22 dogs and negative in 62. Azotemia was present in approximately two-thirds of both groups, with no predictive value identified between PCR-positive and PCR-negative dogs. However, PCR-positive dogs exhibited significantly shorter survival times for both all-cause mortality (median 60 days, range: 8-601 days) and lep-tospirosis-related death (median 27 days, range: 8-67 days) compared to PCR-negative dogs (median 402 days, range: 7-812 days) (P < 0.01). The neutrophil-to-lymphocyte ratio (NLR) in-dependently predicted leptospirosis-related death (HR = 1.073, 95%CI: 1.02-1.13, P = 0.01), while the BUN-to-creatinine ratio predicted all-cause mortality (HR = 1.02, 95% CI: 1.003-1.03, P = 0.02).
Conclusion:
Our findings underscore the severity of leptospirosis in older dogs, particularly those with azotemia or positive PCR results. NLR and BUN to creatinine ratios could be valuable tools for risk assessment and guiding treatment strategies in this vulnerable population.
胡志明市师范大学中文系学生的科学研究现状以及未来的研究方向
Authors: Phí Châu A , Liêm Quách Trọng
Published: October 2024

近5年来，胡志明市师范大学中文系的学生科研活动显著增长，体现在论文数量、参与人数和获奖情况等方面。本文指出，学生的科研领域逐渐多样化，跨越汉语言学，涵盖信息技术、旅游业等多个学科，增强了科研成果的应用性与创新性。然而，学生在选题、资料查找和科研经验积累上仍面临挑战。为了有效应对这些问题，管理基层、教师指导和校内资源的充分利用至关重要。本文基于胡志明市师范大学中文系学生的科研统计数据，对2019至2023年的科研情况进行了全面分析，并提出了提升学生科研效率的建议。
学习结果导向理论对课程结构重建的建议 ——以胡志明市师范大学中文系为例
Authors: Nam Nguyễn Hồng , Bình Tăng Ngọc
Published: October 2024

学习结果导向理论（OBE）是21世纪盛行的教育理念，其理论认为每一个课程设计都应该具有明确的目标导向，拥有已设定具体、可测量的学习目标。而教学活动、评估方法、课程内容、教学资源都应根据学习成果的需求并不断改变。本文基于学习结果导向理论，对胡志明市师范大学中文系的课程结构进行剖析，并提出了若干调整建议，以便更好地适应新形势下汉语人才对社会需求及国际化要求，并在提高教学质量的同时也加强了学习者的实际交际与语言运用能力。
基于移动学习程序考察学生汉语自学能力现状
Authors: Thảo Nguyễn Thị Thanh , Xuân Trần Khai
Published: October 2024

近年来，随着中国经济的发展，汉语在全球的影响力不断增强，越来越多的外国人开始学习汉语，越南也不例外。传统的课堂学习方式已经不能满足学习者的需求，因此，移动学习成为了一种重要的补充形式。越南的学习者越来越多地利用移动学习进行自主学习，这种方式打破了时间和地点的限制，让学习者可以根据自己的进度和需求安排学习。本研究以越南汉语中心学习者的汉语口语学习为研究对象，旨在提高学习者的自主学习能力。我们通过问卷和访谈调查学习者在汉语口语自主学习方面的现状，包括他们的学习水平、课外学习中遇到的问题、对课外学习的期望和看法，以及使用的移动学习工具的类别、频率和目的。通过收集这些数据，我们希望为今后的研究提供参考，制定更有效的教学策略，帮助学习者提高汉语口语能力。
Article: Rendering Platforms Liable for VAT and Import Duties: Desperate Times Call for Desperate Measures, but What about Proper Checks and Balances?/I
Authors: Merkx Madeleine
Published: October 2024

Following the obligations put on platforms under the VAT e-commerce rules that entered into application on 1 July 2021 the European Commission under the Customs reform has proposed to put the obligation to pay import duties on platforms as deemed importer. In this contribution the author analyses the proposed obligations, including those originally included in the VAT in the digital age (VIDA) proposal. She answers the question to what extent platforms are able to deal with these obligations and whether they create undesired issues as regards competition.
Article: Balancing Digitalization and Proportionality: The Progress of the FASTER Initiative*
Authors: Konstantinou Melina , Konstantinou Katherina
Published: October 2024

The European Commission’s proposed directive ‘Faster and Safer Relief of Excess Withholding Taxes’ (FASTER) aims to standardize, modernize, and digitalize the EU-wide withholding tax procedure to enhance efficiency and fraud resistance. The Council of the EU, through Economic and Financial Affairs Council (‘ECOFIN’), has agreed on a revised directive that retains the core objectives but introduces significant modifications. The initiative focuses on simplifying tax relief procedures, introducing a digital EU tax residence certificate, and implementing fast-track refund systems. The Council’s adjustments include extended deadlines for issuing certificates and fast-track refunds, as well as expanded obligations for financial intermediaries to report transactions and prevent fraud. The directive emphasizes digitalization and proportionality in its implementation. However, concerns about the proportionality of imposed liabilities on financial intermediaries and data protection remain critical issues. The revised directive is pending further consultation with the European Parliament and formal adoption by the Council, with an anticipated implementation deadline extended to 31 December 2028, and national application starting 1 January 2030.
Appraising the New EU Appraisal Regime
Authors: Seretakis Alexandros
Published: October 2024

In 2019 the European Union adopted the Mobility Directive(Directive (EU) 2019/2121 of the European Parliament and of the Council of 27 November 2019 amending Directive (EU) 2017/1132 as regards cross-border conversions, mergers and divisions OJ L 321, 12 December 2019, pages 1–44), which improved the rules governing cross-border mergers and introduced harmonized rules for cross-border conversions and cross-border divisions. Most notably, the Directive introduced a harmonized regime for the exercise of appraisal rights in case of crossborder mergers. The new rules, which significantly strengthen minority shareholder protection, are in line with the EU’s goal of fostering capital markets. The present article will seek to analyse the new appraisal regime introduced by the Mobility Directive and offer an evaluation of the regime and its shortcomings. Part I of this article will offer an introducing to appraisal rights and appraisal litigation and examine whether long-standing fears regarding abuse of appraisal rights are justified. Part II will set out the new appraisal regime, while Part III will offer an evaluation of the new provisions and discuss their shortcomings.
Corporate Purpose and Sustainable Decision Making: Examples from Dutch Corporate Practice
Authors: Olaerts Mieke
Published: October 2024

In this contribution we examine the state of the art of purpose statements in Dutch corporate practice. We discuss the general debate on corporate purpose, explore differences between purpose and related terms such as mission and vision, and outline the legal qualification and effects of purpose statements. We also review the Dutch legal background against which purpose statements are used, present empirical findings on the use of these statements over the past decade, and reflect on their value for the sustainable future of companies in a Dutch and European corporate law setting.Overall, we identify that discussions on corporate purpose have influenced Dutch corporate practice. We demonstrate a notable increase in such statements over the past decade and show that they have become increasingly oriented towards sustainability and extrinsic aims. We do not, however, infer from these developments that purpose statements have had a standalone, positive effect on the sustainability of companies since they are often vaguely formulated, seldom included in articles of association, and are typically formulated as a voluntary act by the board. Ultimately, we conclude that the effectiveness of corporate purposes depends on how companies implement them within the regulatory context that is provided by society.
Corporate Governance in Platform Governance: Reassessing Stakeholderism in a Disruptive Era
Authors: Cai Qiang
Published: October 2024

Today, many of the largest and most successful businesses such as Google, Amazon, Apple, and Metaverse (Facebook) operate as online platforms. While they bring vast economic and societal benefits, their negative impacts on the society are increasingly causing public concerns. Despite the consensus that they must be governed, a topdown style of public regulation may not represent an optimal path to address platform ills. In this context, corporate governance that incorporates a stakeholder perspective may provide a preferable means to strengthen platform governance. While stakeholder thinking is not without its criticisms, the context of the platform society and disruptive innovation does provide a strong case for stakeholderism. The latter may therefore have the potential to bridge the topics of platform governance and corporate governance. Platform governance via corporate governance may be institutionalised along multiple lines including, inter alia, stakeholder representation on the board, directors’ fiduciary duty enforceable by stakeholders, the board’s reporting obligation in respect of platform governance, and the stewardship responsibility imposed upon institutional shareholders.
Article: Redefining Global Trade: The Interplay of Geopolitics, Economic Resilience, and Sustainability?
Authors: Aubard Alexandre , Julien Garphil
Published: October 2024

This paper explores the shifting dynamics of global trade amid rising geopolitical tensions between the United States, the European Union, and China. It traces the evolution from post-World War II American-led globalization to hyperglobalization, where China emerged as a global manufacturing powerhouse. While hyperglobalization spurred economic growth and lowered consumer prices, it also led to job losses, income inequality, and environmental degradation in developed economies.The COVID-19 pandemic and the ongoing US-China trade conflict have accelerated a shift towards economic resilience and national security. The US has responded by decoupling from China, particularly in critical sectors like technology and clean energy, viewing economic policy as integral to national security. Meanwhile, the EU, though aligned with the US in geopolitical concerns, remains economically dependent on China and has adopted a more regulatory approach. The EU seeks to balance its economic ties with China by leveraging trade regulations, such as the Carbon Border Adjustment Mechanism (CBAM) and the Corporate Sustainability Reporting Directive (CSRD), to encourage Chinese investment while promoting higher environmental and social standards.The paper also examines the increasing influence of environmental policies on trade, noting how both the US and EU are integrating sustainability into their trade frameworks. However, this trend raises concerns about the potential for environmental regulations to become trade barriers, further complicating international relations.
The Compatibility of the draft EU-Mercosur Free Trade Agreement with EU and International Climate Protection Law
Authors: Verheyen Roda , Winter Gerd
Published: October 2024

Since 1999, the EU and the Mercosur countries have negotiated an Association Agreement (AA) which will include a trade pillar, the Free Trade Agreement (FTA). The latter aims at increasing the amount of goods crossing borders, including products associated with high greenhouse gas emissions or having adverse impacts on forests and other valuable ecosystems. This article assesses whether the adoption of the FTA would contravene the EU’s obligations under international law and EU primary law – with a focus on climate protection.
Efficacy of Endovascular Glue Embolization in Treating Ruptured Intracranial Mycotic Aneurysms: A Single Center Experience
Authors: Purkayastha Sukalyan , Kumar Rajinder , Verma Dinesh , Dhurvey Deepak , Kumar Nitin , Jana Surajit
Published: October 2024

Purpose: Intracranial mycotic aneurysms (IMAs), rare and often life-threatening, result from arterial wall infections typically caused by bacteria such as Staphylococcus and Streptococcus. The standard treatment for ruptured aneurysms is not well-defined and often individualized. This study investigates the efficacy of endovascular glue embolization in managing ruptured IMAs, based on our center’s experience.Materials and Methods: A retrospective analysis was conducted for ruptured IMAs treated with glue embolization between January 2016 and December 2023. The procedure involved aneurysm sac and parent vessel occlusion with glue delivery. Data included patient demographics, clinical presentations, and neuroimaging. Clinical outcomes were assessed using the modified Rankin scale (mRS) at 3 months, and angiographic follow-up was conducted at 6 months.Results: The study included 28 patients, predominantly male (64.3%), with a mean age of 48 years. Headache was the primary symptom in 92.9% of cases, and positive blood/cerebro spinal fluid cultures were found in 82.14% of cases. All aneurysms were located in the distal circulation, primarily in the anterior circulation system. Glue embolization was successfully performed in all cases, achieving complete aneurysm sac and parent vessel obliteration. Follow-up at 3 months indicated mRS scores of 0 or 1 in 96.5% of cases. Six-month angiographic follow-up showed no aneurysm regrowth or new formations.Conclusion: Endovascular glue embolization demonstrated high efficacy and safety in treating ruptured IMAs, with a 100% obliteration rate and favorable clinical outcomes in this single-center experience. Despite limitations such as its retrospective design and small sample size, the study supports glue embolization as a viable, less invasive alternative to traditional surgery. Further comparative studies are needed to confirm these findings and refine treatment approaches.
Research on Practical Curriculum of Vocational and Technical Education From the Perspective of Science and Technology Integration
Authors: Lei Guoqing
Published: October 2024

Theory is the navigation of practice, and practice is the wing of theory. Modern vocational and technical education is increasingly showing the characteristics of technology penetration, practice traction, system support and so on, and its dependence on the correct path and scientific methods is more prominent. Exploring the integration of theory and practice, and adhering to the combination of theory and technology to design courses have become a new window to break through the traditional curriculum model research and teaching, which has far-reaching significance and value.
Empirical Research on the Assessment and Enhancement of Blended Teaching Competence of Integrated English Teachers
Authors: Lyu Jiaorong
Published: October 2024

This research aimed to assess Integrated English teachers’ competence at Guangzhou Institute of Science and Technology. The participants of the study were 275 students who were enrolled in Integrated English course, and 11 teachers who teach this course. The study revealed that the level of teachers’ competence in terms of knowledge, skills and attitudes in Integrated English blended teaching was very high as assessed by the teacher and student participants. However, the challenges and problems encountered by teachers were limited time, insufficient supervision on students’ study and difficulty in assessing individual outputs. Therefore, a plan of action was proposed to improve the teaching of Integrated English through blended mode.
Estratégias da Política Nacional de Transplantes: uma revisão de literatura
Authors: Silva Luciano Cicero da , Guedes Débora Bruna Barbosa , Lima Fabiano de , Filho Hustênio Abílio Appelt , Silva Joana Darc Ferreira da , Bohórquez Karen de Fátima Figueroa , Silva Regirleide Pereira da , Machado Sergio Raimundo Ernesto , Nobre Sheila Érika Ferro Ramalho
Published: October 2024

A Política Nacional de Transplantes de Órgãos no Brasil, criada em 1997, é uma das mais bem estruturadas políticas de saúde pública no país, permitindo o acesso equitativo e eficiente aos transplantes de órgãos e tecidos. Este estudo tem como objetivo analisar os avanços, desafios e perspectivas dessa política. Para tanto, foi realizada uma análise documental de leis, relatórios governamentais e literatura especializada. Os resultados indicam que a política teve sucesso em ampliar a captação e distribuição de órgãos, consolidando o Brasil como um dos maiores realizadores de transplantes no mundo. No entanto, persistem desafios como a escassez de doadores e a desigualdade regional no acesso aos transplantes. A melhoria da infraestrutura hospitalar e a intensificação das campanhas de conscientização são apontadas como soluções para aumentar as doações e otimizar o sistema. Conclui-se que, embora a política tenha alcançado avanços significativos, ajustes contínuos são necessários para que o sistema de transplantes atenda de forma eficaz toda a população brasileira.
AVALIAÇÃO DA EFICÁCIA E INTERCORRÊNCIA ASSOCIADOS AO USO DE TOXINA BOTULÍNICA – RELATO DE CASO
Authors: Araújo Raquel Bel Furioso , Gomes Giovanna Gallo Souza , Silva Camila Arcanjo Ferreira da , Zanqueta Érica Benassi
Published: October 2024

A toxina botulínica tipo A (TBA) ganhou popularidade como uma alternativa não cirúrgica, destacando-se pela sua eficácia tanto em aplicações corretivas quanto preventivas na região facial. Esse procedimento raramente desencadeia reações imunológicas e permite uma recuperação rápida, com mínimas limitações nas atividades diárias dos pacientes. Contudo, é crucial que a substância seja administrada corretamente, a fim de evitar movimentos indesejados ou expressões faciais que pareçam artificiais. O presente trabalho foi aprovado pelo Comitê de Ética em Pesquisa (CEP) da Uningá, com número de protocolo 7.020.366 e tem como objetivo explorar a aplicabilidade da TBA e as possíveis intercorrências associadas ao seu uso. O caso relatado ressalta a importância de buscar profissionais qualificados para a realização de procedimentos estéticos, especialmente aqueles que envolvem a injeção de substâncias como a TBA. A paciente apresentou uma melhora significativa na simetria facial, corrigindo a assimetria anterior. Portanto, uma avaliação detalhada e um planejamento cuidadoso são fundamentais para assegurar a segurança e a satisfação do paciente.
PERFIL EPIDEMIOLÓGICO DE SÍFILIS ADQUIRIDA E INCIDÊNCIA DE CASOS EM MANAUS NO ANO DE 2023
Authors: Cunha Lívia Amazonas da , Avelino Bruna da Silva Souza
Published: October 2024

Por meio de levantamento de dados da Fundação de Vigilância em Saúde do Amazonas (FVS) e do Datasus tabnet, de artigos, revisão literárias e informativos e sites de pesquisa, foram caracterizados o perfil epidemiológico e a incidência dos casos de sífilis adquirida no município de Manaus no ano de 2023 e comparados com o ano de 2022. O estudo busca descrever a incidência da sífilis adquirida do ano de 2023 em Manaus, assim como o perfil epidemiológico da população avaliada por indicadores limitados. Com obejtivo específico de descrever a evolução da história da sífilis e os casos de Tuskegee e Guatemala.
GERENCIAMENTO DE RESÍDUOS NA PERSPECTIVA DA ECONOMIA AZUL NO RIO DE JANEIRO
Authors: Almeida Riezo Silva , Albarello Beatriz Amália , Pineo Maria Eduarda de Sousa , Moreira Daniel Gomes , Rowlands Bernardo Rocha , Bonavita Giuseppe Castro
Published: October 2024

O aumento da população nas cidades e a crescente urbanização têm intensificado a produção de resíduos sólidos, resultando em impactos ambientais, como a poluição dos solos, águas e atmosfera. Assim, a economia azul surge como uma abordagem inovadora e sustentável para o gerenciamento de resíduos, especialmente em cidades costeiras e regiões com ecossistemas marinhos ricos. Este estudo objetivou-se compreender sobre a poluição marinha e as ações de controle e gestão de resíduos no Estado do Rio de Janeiro, com sua extensa costa e uma rica biodiversidade marinha e entender de que forma a comunidade costeira tem conduzido suas práticas a não causar danos ao meio ambiente. Em parceria com pesquisadores do Instituto Federal do Rio de Janeiro, foi realizado um levantamento sobre o ecossistema na região dos lagos, entre os municípios de Arraial do Cabo, Cabo Frio, Búzios, Maricá. Para tanto, foram levantadas questões sobre o impacto ambiental e como as mudanças climáticas estão afetando a biodiversidade marinha e costeira juntamente com pescadores e moradores locais da comunidade costeira da região dos lagos para compreender o cenário sobre o conceito Economia Azul. Os resultados apontam para práticas interventivas de educação ambiental feitas por vários institutos locais, que visam promover os ecossistemas marinhos e o cuidado que a comunidade local deve ter com o gerenciamento de resíduos sólidos, com vistas ao desenvolvimento econômico, melhoria do bem-estar social, bem como também para a conservação e a saúde dos ecossistemas oceânicos.
Ảnh hưởng của chất độn than đen và tricresyl phosphate đến tính chất của cao su nitrile butadiene
Authors: Đoàn Văn Điệp  , Nguyễn Thanh Liêm  , Nguyễn Đức Long  , Nguyễn Văn Hùng
Published: October 2024

Bài báo đưa ra kết quả nghiên cứu ảnh hưởng của tricresyl phosphate đến một số tính chất của cao su nitrile butadiene được gia cường bằng than đen kỹ thuật. Kết quả cho thấy mẫu đạt độ bền cơ học tốt nhất ở hàm lượng than đen 60 pkl. Ngoài ra, tác động của tricresyl phosphate cũng được so sánh với các chất hóa dẻo thông dụng khác như tributyl phosphate, dioctyl phthalate và dioctyl sebacate. Theo đó, các chất hóa dẻo đều làm giảm độ bền kéo và độ cứng, đồng thời làm tăng độ giãn dài của vật liệu. Đặc biệt, đặc tính chống cháy của các mẫu cao su cũng được đánh giá thông qua giá trị chỉ số oxy giới hạn (LOI) và tốc độ cháy ngang, cung cấp thông tin quan trọng cho việc phát triển các vật liệu cao su trên nền cao su nitrile butadiene.
Nghiên cứu thiết kế, chế tạo liều phóng cho động cơ hành trình thiết bị bay MTB01 từ thuốc phóng RST
Authors: Phạm Quang Hiếu  , Bùi Anh Thức  , Phạm Văn Toại  , Phạm Kim Đạo  , Mai Văn Tú
Published: October 2024

Bài báo trình bày kết quả nghiên cứu, chế tạo và thử nghiệm động cơ hành trình thiết bị bay MTB01 sử dụng thuốc phóng rắn RST của tên lửa V. Trong đó, đã nghiên cứu tính toán thiết kế chế tạo liều phóng, công nghệ chế tạo lớp phủ chống cháy cho thỏi thuốc phóng rắn và thử nghiệm động cơ hành trình. Kết quả các động cơ thử nghiệm hoạt động ổn định, các thông số chính thu được như sau: Áp suất Pmax = 61,9 bar; thời gian cháy 31,75 giây; lực đẩy động cơ trung bình 670,7 N; tổng xung lực đẩy 21247,9 N.s; nhiệt độ vỏ động cơ trong khoảng thời gian động cơ làm việc tương đương nhiệt độ môi trường, sau khi động cơ ngừng hoạt động nhiệt độ vỏ động cơ tăng đến 86 oC. Đây là động cơ hành trình sử dụng thuốc phóng rắn có kích thước lớn nhất do các đơn vị trong nước phối hợp nghiên cứu và chế tạo, trên cơ sở đó tạo được một loại mục tiêu bay MTB01 mới có tốc độ lớn nhất đạt 248 m/s, thời gian bay không nhỏ hơn 60 giây.
Nghiên cứu chế tạo vật liệu mang năng lượng từ nitrate cellulose, cellulose và polyester không no
Authors: Phạm Văn Khương  , Đỗ Đức Trí  , Nguyễn Mạnh Tường  , Hoàng Thế Vũ
Published: October 2024

Bài báo trình bày kết quả nghiên cứu, chế tạo vật liệu compozit mang năng lượng từ nitrate cellulose (NC), cellulose (C) và polyester không no. Kết quả cho thấy, mẫu vật liệu có các tính chất tương đương với các sản phẩm trong các công trình đã công bố của nước ngoài khi có tỷ lệ NC:C- 80:20 và hàm lượng dung dịch 50% polyethylene glycol maleate phthalate trong triethylene glycol dimethacrylate 15%, vật liệu có độ bền kéo không nhỏ hơn 10 MPa (11,56 MPa), độ giãn dài không nhỏ hơn 1,5% (4,2%), nhiệt lượng cháy không dưới 500 kcal/kg (513,6 kcal/kg), nhiệt độ chớp cháy không dưới 180 oC (193 oC).
Preparation and study of some characteristics of spherical gunpowder based on nitrocellulose and DINA
Authors: Phan Duc Nhan  , Nguyen Minh Tuan  , Doan Minh Khai
Published: October 2024

This article presents the results of research on the selection of components, recipes, method and technological regime for the production of spherical gunpowders based on nitrocellulose (grade Pi-BA) and ethylene glycol-N-nitramine dinitrate (DINA), as well as the results of studying some of their characteristics. In these gunpowders, DINA plays the role of an energetic plasticizer with a content in the range of 8.2 - 39.4% by mass. The selected technological regime allows to obtain spherical gunpowders with high yield on a laboratory scale (over 95% for particle sizes less than 1 mm and over 90% for particle sizes in the range of 0.2 - 0.8 mm). The obtained samples of spherical gunpowders have a density in the range of 1.60 - 1.62 g/cm3 and a bulk density in the range of 0.98 - 1.02 g/cm3, which well meets the requirements commonly applied to these criteria for military-use spherical gunpowders. The introduction of DINA has slight effect on the auto-ignition temperature of the obtained samples. Theoretical calculations of some energetic characteristics using the REALWIN program also show the potential of using DINA to replace nitroglycerin as a second energetic component in the development of high-energy spherical gunpowder.
Click-and-Trade Structured Products for Wealth Management
Authors: Wystup Uwe
Published: October 2024

This issue we speak to Milind Kulkarni, founder of FinIQ, who pioneered technology for making structured products accessible beyond large institutional users
Detecting And Predicting Price Jumps With Consecutive Signature Distance
Authors: Bloch D and Liao, E and Bloch, A
Published: October 2024

In order to estimate the hidden states of dynamical systems, Jump Models cluster financial observations along time series and impose a cost on jumping from one cluster to another. While these models can detect abrupt changes in the underlying time series, they suffer from two major drawbacks when it comes to detecting price jumps: (1) they cannot detect two (or more) consecutive jumps; (2) they cannot dissociate high volatility from jumps. To remedy these drawbacks, Bloch and Liao consider two seemingly unrelated problems: (1) Detecting and predicting price jumps by identifying whether a new observation results in a price jump relative to previous observations; (2) Anomaly detection of segments of a time series, that is, fixed size segments of a time series are treated as a normal corpus, and search for outliers. It is observed that while these problems are clearly different, the former can be reformulated in terms of the latter and they can therefore associate jump indicators to data-driven metrics for anomaly detection. Bloch and Liao propose a three-step process: (1) jump detection: the variance norm is combined with path signatures to come up with a data-driven jump indicator; (2) training: Bloch and Liao use this Variance Norm Jump Indicator as an input feature for Jump Models; (3) prediction: the authors use new incoming data to predict its hidden state. This approach aims at enhancing the model�s accuracy and predictive capabilities by leveraging the strengths of variance norm on detecting data points after the jump as outliers from previous distribution. Bloch and Liao conducted an extensive analysis on simulated data, examining the structure, benefits and limitations of the approach, and found that they could retrieve the true hidden states with high accuracy without using future information.
Great Year Bad Sharpe
Authors: Smerlak Matteo
Published: October 2024

Returns distributions are heavy tailed across asset classes. In this note, Smerlak examines the implications of this well-known stylized fact for the joint statistics of performance (absolute return) and Sharpe ratio (risk-adjusted return). Using both synthetic and real data, He shows that, all other things being equal, the investments with the best in-sample performance are never associated with the best in-sample Sharpe ratios (and vice versa). This counter-intuitive effect is unrelated to the risk-return tradeoff familiar from portfolio theory: it is, rather, a consequence of asymptotic correlations between the sample mean and sample standard deviation of heavy-tailed variables. In addition to its large sample noise, this non-monotonic association of the Sharpe ratio with performance puts into question its status as the gold standard metric of investment quality.
PERSONAL-ORIENTED TECHNOLOGIES FOR FORMING THE FOUNDATIONS OF AN INCLUSIVE CULTURE UNIVERSITY STUDENTS
Authors: Сысоева Е.Ю.
Published: October 2024

В статье проанализирована направленность инклюзивного образования в вузе. Обоснованы методологические, содержательные и технологические аспекты формирования основ инклюзивной культуры студентов вуза, описан опыт внедрения личностно ориентированных технологий обучения инклюзивному взаимодействию в вузе.

The article analyzes the direction of inclusive education at a university. The methodological, substantive and technological aspects of forming the foundations of an inclusive culture for university students are substantiated, and the experience of introducing student-oriented technologies for teaching inclusive interaction at a university is described.
STAGES OF FORMATION OF SOCIAL AND PROFESSIONAL IDENTITY OF STUDENTS – FUTURE TEACHERS OF PHYSICAL CULTURE
Authors: Фаварисов Э.А.
Published: October 2024

Актуальность исследования обусловлена тем, что именно в высшей школе студент утверждается в правильности выбранного профессионального пути, и определяет свои профессиональные перспективы. Цель исследования – уточнить этапы формирования социально-профессиональной идентичности студентов – будущих учителей физической культуры в соответствии со спецификой преподаваемой ими дисциплины. Раскрыта сущность понятия «социально-профессиональная идентичность», которое рассматривается как процесс профессионализации, осуществляемый через принятие или непринятие смысложизненных ценностей, позволяющих ощутить самоудовлетворение от результатов своей профессионально деятельности. Предложено, что специфика студентов – будущих учителей физической культуры заключается в том, что они с ранних лет вовлечены в спортивно-соревновательную деятельность, соответственно, более уверены в правильности выбранного ими профессионального пути. Доказано, что идентичность следует рассматривать в единстве её социальной (адаптация в сообществе) и профессиональной (профессиональное становление личности) составляющих. Автор приходит к выводу, что формирование социально-профессиональной идентичности – непрерывный процесс, поскольку он основывается на продвижении профессионального знания.

The relevance of the research is caused due to the fact that the student approves in correctness of the chosen professional way, and defines the professional perspectives in the course of studying in the university. A research objective is to specify stages of formation of social and professional identity of students-future teachers of physical culture according to specifics of the discipline, which is being taught. The essence of the concept “social and professional identity” is revealed which can be treated as the professionalizing process which is carried out through acceptance or rejection of the meaning and vital values, allowing them to feel self-satisfaction from results of their professionally of activity. It is suggested that the specifics of students-future teachers of physical culture is that they have been involved in sports and competitive activity since early years. Respectively, they are surer in the correctness of their professional way. It is substantiated that the identity should be considered in the unity of its social (adaptation to the community) and professional (professional formation of the personality) components. The author comes to a conclusion that formation of social and professional identity is a continuous process as it is based on enhancing of professional knowledge.
METHODOLOGICAL APPROACH IN THE PSYCHOLOGICAL REHABILITATION OF PEOPLE WHO HAVE SUFFERED ACUTE AND CHRONIC STRESS
Authors: Ковшова О.С.
Published: October 2024

В статье с методологическим обоснованием рассматривается клинико-психологическое сопровождение военнослужащих (40 человек), участников специальной военной операции и мужчин, участников Афганской войны, которые проходили медико-психологическую реабилитацию в Самарском госпитале ветеранов войн в 2023 году. Установлено, что в развитии посттравматических стрессовых нарушений (ПТСН) наименее благоприятной является 1-я группа – мужчины-участники СВО. У них преобладает демонстративно-возбудимая типология личности, высокие показатели тревоги и депрессии, снижение фрустрационной толерантности и социальной адаптации. На основании полученных результатов исследования разработан диагностический алгоритм – получена регрессионная математическая модель значимых психологических факторов – типа и направления эмоционального реагирования – «переработка агрессии» (E/e), сумма необходимо-упорствующих реакций (∑NP), позволяющая в 70 % достоверно прогнозировать развитие ПТСН у воинов. Диагностика психологических факторов, участвующих в развитии ПТСН у военнослужащих, способствует сохранению и восстановлению психологического здоровья и эффективной его медико-психологической реабилитации участников СВО.

The article with methodological justification examines the clinical and psychological support of military personnel (40 people), participants in a special military operation and men, participants in the Afghan war, who underwent medical and psychological rehabilitation at the Samara Hospital of War Veterans in 2023. It was found that in the development of post-traumatic stress disorders (PTSD), the least favorable group is 1st – male participants of the SVO. They are dominated by a demonstratively excitable personality typology, high rates of anxiety and depression, a decrease in frustration tolerance and social adaptation. Based on the results of the study, a diagnostic algorithm was developed – a regression mathematical model of significant psychological factors was obtained – the type and direction of emotional response – “processing aggression” (E/e), the sum of necessary-persistent reactions (∑NP), which allows 70 % to reliably predict the development of PTSD in warriors. The diagnosis of psychological factors involved in the development of PTSD in military personnel contributes to the preservation and restoration of psychological health and its effective medical and psychological rehabilitation of the participants of the SVO.
THE READINESS OF TEACHERS OF A PRESCHOOL EDUCATIONAL ORGANIZATION TO IMPLEMENT THE EDUCATIONAL TASKS OF A KINDERGARTEN
Authors: Николаева Э.Ф.
Published: October 2024

В статье рассматривается проблема готовности педагогов дошкольной образовательной организации к выполнению задач воспитательной деятельности учреждения, где она рассматривается как важный фактор эффективности деятельности по воспитанию личности ребенка-дошкольника, а также как важный компонент профессиональной компетентности педагога. Представлено краткое обоснование готовности как сложного и многоаспектного комплекса знаний, специальных навыков, качеств профессиональной личности педагога, его компетентности и как специального состояния, способного обеспечивать устойчивую направленность специалиста на поиск эффективных способов решения задач воспитания, благодаря которому посредством рефлексии и самоанализа деятельности актуализируется возможность планирования маршрутов развития профессиональной компетентности, расширения технологического и технического оснащения деятельности, а также личностное развитие и совершенствование педагогов для целенаправленного и качественного решения задач воспитания. Представлены результаты эмпирического исследования специфики готовности педагогов дошкольной образовательной организации к продуктивной деятельности по воспитанию детей, качественные характеристики готовности и содержательный анализ выделенных испытуемыми компонентов готовности к воспитательной деятельности и качественному решению ее задач, стоящих перед дошкольным образованием.

The article deals with the problem of teachers of a preschool educational organization’s readiness to perform the tasks of educational activities of an institution, where it is considered as an important factor in the effectiveness of activities to educate the personality of a preschool child, as well as an important component of the professional competence of a teacher. The article presents a brief justification of readiness as a complicated and multidimensional complex of knowledge, special skills, qualities of a professional personality of a teacher, his competence, and as a special condition capable of ensuring a steady focus of a specialist on finding effective ways to solve educational problems, thanks to which, through reflection and introspection of activities, the possibility of planning routes for the development of professional competence, expansion of technological and technical equipment of the activity, as well as personal development and improvement of teachers for purposeful and quality. The article presents the results of an empirical study of the specifics of teachers’ readiness for productive activities in child rearing, highlights the qualitative characteristics of readiness and a meaningful analysis of the components of readiness for educational activity identified by the subjects and the qualitative solution of its tasks facing preschool education.