bluuebunny/crossref_metadata_2025 huggingface dataset:
From spectral to scattering form factor
Authors: Bianchi Massimo , Firrotta Maurizio , Sonnenschein Jacob , Weissman Dorin
Published: June 2024

Abstract

We propose a novel indicator for chaotic quantum scattering processes, the scattering form factor (ScFF). It is based on mapping the locations of peaks in the scattering amplitude to random matrix eigenvalues, and computing the analog of the spectral form factor (SFF). We compute the spectral and scattering form factors of several non-chaotic systems. We determine the ScFF associated with the phase shifts of the leaky torus, closely related to the distribution of the zeros of Riemann zeta function. We compute the ScFF for the decay amplitude of a highly excited string states into two tachyons. We show that it displays the universal features expected from random matrix theory - a decline, a ramp and a plateau - and is in general agreement with the Gaussian unitary ensemble. It also shows some new features, owning to the special structure of the string amplitude, including a “bump” before the ramp associated with gaps in the average eigenvalue density. The “bump” is removed for highly excited string states with an appropriate state dependent unfolding. We also discuss the SFF for the Gaussian β-ensemble, writing an interpolation between the known results of the Gaussian orthogonal, unitary, and symplectic ensembles.
Towards systematic evaluation of de Sitter correlators via Generalized Integration-By-Parts relations
Authors: Chen Jiaqi , Feng Bo
Published: June 2024

Abstract

We generalize Integration-By-Parts (IBP) and differential equations methods to de Sitter correlators related to inflation. While massive correlators in de Sitter spacetime are usually regarded as highly intricate, we find they have remarkably hidden concise structures from the perspective of IBP. We find the factorization of the IBP relations of each vertex integral family corresponding to dτi integration. Furthermore, with a smart construction of master integrals, the universal formulas for iterative reduction and d log-form differential equations of arbitrary vertex integral family are presented and proved. These formulas dominate all tree-level de Sitter correlators and play a kernel role at the loop-level as well.
Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factors
Authors: Tindall Rachel R. , Yang Yuntao , Hernandez Isabella , Qin Amy , Li Jiajing , Zhang Yinjie , Gomez Thomas H. , Younes Mamoun , Shen Qiang , Bailey-Lundberg Jennifer M. , Zhao Zhongming , Kraushaar Daniel , Castro Patricia , Cao Yanna , Zheng W. Jim , Ko Tien C.
Published: June 2024

The rapidly aging population is consuming more alcohol, leading to increased alcohol-associated acute pancreatitis (AAP) with high mortality. However, the mechanisms remain undefined, and currently there are no effective therapies available. This study aims to elucidate aging- and alcohol-associated spatial transcriptomic signature by establishing an aging AAP mouse model and applying Visium spatial transcriptomics for understanding of the mechanisms in the context of the pancreatic tissue. Upon alcohol diet feeding and caerulein treatment, aging mice (18 months) developed significantly more severe AAP with 5.0-fold increase of injury score and 2.4-fold increase of amylase compared to young mice (3 months). Via Visium spatial transcriptomics, eight distinct tissue clusters were revealed from aggregated transcriptomes of aging and young AAP mice: five acinar, two stromal, and one islet, which were then merged into three clusters: acinar, stromal, and islet for the comparative analysis. Compared to young AAP mice, > 1300 differentially expressed genes (DEGs) and approximately 3000 differentially regulated pathways were identified in aging AAP mice. The top five DEGs upregulated in aging AAP mice include Mmp8, Ppbp, Serpina3m, Cxcl13, and Hamp with heterogeneous distributions among the clusters. Taken together, this study demonstrates spatial heterogeneity of inflammatory processes in aging AAP mice, offering novel insights into the mechanisms and potential drivers for AAP development.

Key messages

Mechanisms regarding high mortality of AAP in aging remain undefined.

An aging AAP mouse model was developed recapturing clinical exhibition in humans.

Spatial transcriptomics identified contrasted DEGs in aging vs. young AAP mice. Top five DEGs were Mmp8, Ppbp, Serpina3m, Cxcl13, and Hamp in aging vs. young AAP mice.

Our findings shed insights for identification of molecular drivers in aging AAP.
Immersive virtual reality as a novel approach to investigate the association between adverse events and adolescent paranoid ideation
Authors: Gayer-Anderson Charlotte , Knowles Gemma , Beards Stephanie , Turner Alice , Stanyon Daniel , Davis Sam , Blakey Rachel , Lowis Katie , Dorn Lynsey , Ofori Aisha , Rus-Calafell Mar , Morgan Craig , Valmaggia Lucia
Published: June 2024

Purpose

Paranoid ideation is common among adolescents, yet little is known about the precursors. Using a novel immersive virtual reality (VR) paradigm, we tested whether experiences of bullying, and other interpersonal/threatening events, are associated with paranoid ideation to a greater degree than other types of (i) non-interpersonal events or (ii) adverse childhood experiences.

Methods

Self-reported exposure to adverse life events and bullying was collected on 481 adolescents, aged 11–15. We used mixed effects (multilevel) linear regression to estimate the magnitude of associations between risk factors and paranoid ideation, assessed by means of adolescents’ reactions to ambiguously behaving avatars in a VR school canteen, adjusting for putative confounders (gender, year group, ethnicity, free school meal status, place of birth, family mental health problems).

Results

Lifetime exposure to interpersonal/threatening events, but not non-interpersonal events or adverse circumstances, was associated with higher levels of state paranoid ideation, with further evidence that the effect was cumulative (1 type: ϐadj 0.07, 95% CI -0.01-0.14; 2 types: ϐadj 0.14, 95% CI 0.05–0.24; 3 + types: ϐadj 0.24, 95% CI 0.12–0.36). More tentatively, for girls, but not boys, recent bullying was associated with heightened paranoid ideation with effect estimates ranging from ϐadj 0.06 (95% CI -0.02-0.15) for physical bullying to ϐadj 0.21 (95% CI 0.10–0.32) for cyber bullying.

Conclusions

Our data suggest a degree of specificity for adversities involving interpersonal threat or hostility, i.e. those that involve unwanted interference and/or attempted control of an individual’s personal boundaries being associated with heightened levels of state paranoid ideation among adolescents.
Benefit of classical leveling for geoid-based vertical reference frames
Authors: Gerlach Christian , Rummel Reiner
Published: June 2024

Classically, vertical reference frames were realized as national or continent-wide networks of geopotential differences derived from geodetic leveling, i.e., from the combination of spirit leveling and gravimetry. Those networks are affected by systematic errors in leveling, leading to tilts in the order of decimeter to meter in larger networks. Today, there opens the possibility to establish a worldwide unified vertical reference frame based on a conventional (quasi)geoid model. Such a frame would be accessible through GNSS measurements, i.e., physical heights would be derived by the method of GNSS-leveling. The question arises, whether existing geodetic leveling data are abolished completely for the realization of vertical reference frames, are used for validation purposes only, or whether existing or future geodetic leveling data can still be of use for the realization of vertical reference frames. The question is mainly driven by the high quality of leveled potential differences over short distances. In the following we investigate two approaches for the combination of geopotential numbers from GNSS-leveling and potential differences from geodetic leveling. In the first approach, both data sets are combined in a common network adjustment leading to potential values at the benchmarks of the leveling network. In the second approach, potential differences from geodetic leveling are used as observable for regional gravity field modeling. This leads to a grid of geoid heights based on classical observables like gravity anomalies and now also on leveled potential differences. Based on synthetic data and a realistic stochastic model, we show that incorporating leveled potential differences improves the quality of a continent-wide network of GNSS-heights (approach 1) by about 40% and that formal and empirical errors of a regional geoid model (approach 2) are reduced by about 20% at leveling benchmarks. While these numbers strongly depend on the chosen stochastic model, the results show the benefit of using leveled potential differences for the realization of a modern geoid-based reference frame. Independent of the specific numbers of the improvement, an additional benefit is the consistency (within the error bounds of each observation type) of leveling data with vertical coordinates from GNSS and a conventional geoid model. Even though we focus on geodetic leveling, the methods proposed are independent of the specific technique used to observe potential (or equivalently height) differences and can thus be applied also to other techniques like chronometric or hydrodynamic leveling.
Protective effect of astaxanthin on indomethacin-induced gastric ulcerations in mice
Authors: Aly Mohamed H. , Said Aya K. , Farghaly Aya M. , Eldaly Dalia A. , Ahmed Dina S. , Gomaa Maram H. , Elgebaly Nazih H. , Sameh Omar , Elahwany Salma K. , Ebrahem Tasneem T. , Sameh Youssif , Wally Maha E.
Published: June 2024

Gastric ulcer disease remains one of the common medical burdens affecting millions worldwide due to its prevalent risk factors with the chronic usage of non-steroidal anti-inflammatory drugs at the top, reportedly through the stimulation of oxidative stress and triggering of inflammatory and apoptotic cascades in the gastric mucosa. Astaxanthin, a dietary keto-carotenoid derived from marine organisms is gaining a wide interest as a nutraceutical for its pronounced antioxidant properties. Here, we aim to examine the potential modulatory role of astaxanthin on indomethacin-induced gastric ulceration in experimental mice. Twenty-four Swiss albino mice were randomly distributed into four groups: a control group, an indomethacin group, and two groups pre-treated with either omeprazole or astaxanthin. The gastric tissues were assessed using gross morphology, ulcer scoring, gastric juice acidity, as well as reduced glutathione (GSH) and malondialdehyde (MDA) levels. Histopathological examination and immunostaining for nuclear factor-kappa B (NF-κB) and caspase-3 levels were also employed. Indomethacin group tended to show a higher number of mucosal ulcerations relative to control and pre-treated groups. The indomethacin group also showed significantly lower GSH levels and higher MDA levels relative to control. Immunostaining of gastric tissue sections showed a higher reactivity to NF-﻿κB and caspase-3 in indomethacin group. Astaxanthin pre-treatment significantly elevated gastric juice pH, normalized GSH levels, and lowered the indomethacin-induced elevations in MDA, NF-﻿κB, and caspase-3 levels. These results indicate that astaxanthin exhibits a comparable protective effect to omeprazole, against indomethacin-induced gastric ulceration. This anti-ulcerogenic effect could be mediated through its antioxidant, anti-inflammatory, and anti-apoptotic modulatory activities.

Graphical Abstract
Diagnostic Value of 99mTc-MIBI Myocardial Perfusion Imaging in Detecting Myocardial Ischemia of Children with Kawasaki Disease and Coronary Artery Lesions
Authors: Gui Yiting , Lin Yixiang , Wu Ha , Dai Guangan , Liang Xuecun , Chu Chen , Zheng Yuanzheng , Zhao Quming , Wang Feng , Sun Shuna , Huang Guoying , Yan Weili , He Lan , Liu Fang
Published: June 2024

Pediatric patients with coronary artery lesions (CALs) after Kawasaki disease (KD) may be complicated with myocardial ischemia. Although previous studies in adults have proven the diagnostic value of 99mTc-MIBI myocardial perfusion imaging (MPI) for ischemic heart disease, its feasibility and accuracy in this pediatric population remain uncertain. In this retrospective study, we collected data of 177 pediatric patients (Age range: 6 months to 14 years) who had undergone MPI and coronary artery angiography (CAG) between July 2019 and February 2023. Using the positive result of CAG as the reference standard of myocardial ischemia, we compared the results of 99mTc-MIBI MPI with other non-invasive examinations, including cardiac magnetic resonance imaging (CMRI), echocardiogram, and comprehensive electrocardiogram-related examinations. All patients finished adenosine triphosphate stress MPI without major side effects. The sensitivity of MPI was 79.17%, which was greater than CMRI and echocardiogram (P < 0.05). The negative predictive value and the accuracy of MPI were 89.9% and 71.75%, indicating the advantages over others. Composite monitoring strategy of MPI and CMRI effectively improved the diagnostic performance (P < 0.001). In 4 cases diagnosed with myocardial ischemia by “MPI + CMRI,” despite the absence of significant stenosis, multiple giant coronary artery aneurysms (GCAA) were all observed in CAG. 99mTc-MIBI MPI is the preferred non-invasive examination for detecting myocardial ischemia in pediatric patients with CAL after KD. When combined with CMRI, it can enhance diagnostic accuracy. Multiple GCAAs without stenosis may be an isolated risk factor of myocardial ischemia.
Recover of Soil Microbial Community Functions in Beech and Turkey Oak Forests After Coppicing Interventions
Authors: Picariello Enrica , De Nicola Flavia
Published: June 2024

Forest management influences the occurrence of tree species, the organic matter input to the soil decomposer system, and hence, it can alter soil microbial community and key ecosystem functions it performs. In this study, we compared the potential effect of different forest management, coppice and high forest, on soil microbial functional diversity, enzyme activities and chemical-physical soil properties in two forests, turkey oak and beech, during summer and autumn. We hypothesized that coppicing influences soil microbial functional diversity with an overall decrease. Contrary to our hypothesis, in summer, the functional diversity of soil microbial community was higher in both coppice forests, suggesting a resilience response of the microbial communities in the soil after tree cutting, which occurred 15–20 years ago. In beech forest under coppice management, a higher content of soil organic matter (but also of soil recalcitrant and stable organic carbon) compared to high forest can explain the higher soil microbial functional diversity and metabolic activity. In turkey oak forest, although differences in functional diversity of soil microbial community between management were observed, for the other investigated parameters, the differences were mainly linked to seasonality. The findings highlight that the soil organic matter preservation depends on the type of forest, but the soil microbial community was able to recover after about 15 years from coppice intervention in both forest ecosystems. Thus, the type of management implemented in these forest ecosystems, not negatively affecting soil organic matter pool, preserving microbial community and potentially soil ecological functions, is sustainable in a scenario of climate change.
Uncovering the Role of Autochthonous Deteriogenic Biofilm Community: Rožanec Mithraeum Monument (Slovenia)
Authors: Ljaljević Grbić M. , Dimkić Ivica , Janakiev Tamara , Kosel Janez , Tavzes Črtomir , Popović Slađana , Knežević Aleksandar , Legan Lea , Retko Klara , Ropret Polonca , Unković Nikola
Published: June 2024

The primary purpose of the study, as part of the planned conservation work, was to uncover all aspects of autochthonous biofilm pertaining to the formation of numerous deterioration symptoms occurring on the limestone Rožanec Mithraeum monument in Slovenia. Using state-of-the-art sequencing technologies combining mycobiome data with observations made via numerous light and spectroscopic (FTIR and Raman) microscopy analyses pointed out to epilithic lichen Gyalecta jenensis and its photobiont, carotenoid-rich Trentepohlia aurea, as the origin of salmon-hued pigmented alterations of limestone surface. Furthermore, the development of the main deterioration symptom on the monument, i.e., biopitting, was instigated by the formation of typical endolithic thalli and ascomata of representative Verrucariaceae family (Verrucaria sp.) in conjunction with the oxalic acid-mediated dissolution of limestone. The domination of lichenized fungi, as the main deterioration agents, both on the relief and surrounding limestone, was additionally supported by the high relative abundance of lichenized and symbiotroph groups in FUNGuild analysis. Obtained results not only upgraded knowledge of this frequently occurring but often overlooked group of extremophilic stone heritage deteriogens but also provided a necessary groundwork for the development of efficient biocontrol formulation applicable in situ for the preservation of similarly affected limestone monuments.
Myosteatosis in multiple myeloma: a key determinant of survival beyond sarcopenia
Authors: Diallo Thierno D. , Blessing Ariane Irma Luise , Ihorst Gabriele , Möller Mandy Deborah , Jungmann Pia M. , Bamberg Fabian , Herget Georg , Wäsch Ralph , Engelhardt Monika , Neubauer Jakob
Published: June 2024

Objective

Fatty infiltration of skeletal muscle (Myosteatosis) is associated with increased frailty, decreased muscle and mobility function, which seems fairly prevalent in multiple myeloma (MM) patients. This study aimed to determine the prognostic value of myosteatosis assessed by CT for progression-free survival (PFS) and overall survival (OS).

Materials and methods

This IRB-approved cohort study included patients with newly diagnosed MM who were treated at a single university hospital and received CT at baseline. Geriatric assessment was performed via International Myeloma Working Group frailty score and Revised Myeloma Comorbidity Index. Myosteatosis was determined through measurement of paravertebral muscle radiodensity. Statistical analyses included uni- and multivariable Cox proportional hazard models and the Kaplan–Meier-method.

Results

A total of 226 newly diagnosed MM patients (median age: 65 years [range: 29–89], 63% males, mean BMI: 25 [14–42]) were analyzed. The prevalence of myosteatosis was 51%. Muscle radiodensity was significantly decreased in individuals with International Staging System stage III vs. I (p < 0.001), indicating higher fatty muscle infiltration in patients with advanced disease. Both PFS and OS were significantly decreased in patients with myosteatosis (PFS: median 32.0 months (95% CI 20.5.5–42.2) vs. 66.4 months without myosteatosis (95% CI 42.5-not reached), p < .001); OS: median 58.6 (95% CI 51.3—90.2) vs. not reached, p < .001).

Myosteatosis remained an independent predictor of OS in multivariable analyses (HR: 1.98; 95%-CI: 1.20–3.27).

Conclusion

Myosteatosis seems fairly prevalent in patients with newly diagnosed MM and associated with impaired overall survival. Prospective clinical trials are required to better understand the role of myosteatosis in MM patients.
The Use of Cross-Linked Hyaluronic Acid in Non-surgical Rhinoplasty Using Italian Technique
Authors: Scarano Antonio , Sbarbati Andrea , Amuso Domenico , Amore Roberto , Tari Segio Rexhep , Alla Iris
Published: June 2024

Introduction

Projection and upper rotation to the tip is fundamental in the nasal rejuvenation, as a matter of fact the tip is the most important and has strongly effects on the improve appearance and quality of life. The aim of the present study was to evaluate reshaping the tip of the nose by cross-linked hyaluronic acid using Italian technique.

Methods

In a period between November 2019 and 2023, a total of one hundred and forty healthy, 95 females and 45 man patients, were performed with a mean age 44±5 (age range: 31–52 years old) affected by tip of congenital (22) or ageing nose hypotonia (118), and reduced volume that need of an elevation of the nose tip. The anatomic markers have been considered for the anthropometric measurements after the filler rhinoplasty. Two infiltrations were performed, one in the infiltration into the antero-caudal access over the columella produce upward rotation of the tip of the nose and second infiltration into the antero-superior access produce the projection of the tip of the nose. Medical device used in the study was Neofound STRUCT LIDO (LOVE COSMEDICAL srls–Via Toniolo 9, 57022 Castagneto Carducci, ITALY) containing sodium hyaluronate/hyaluronic acid high molecular weight (1.500<HA<2.000 KDA) 24%, sodium hyaluronate/hyaluronic acid low molecular weight (155<HA<230 KDA) 9%, niacinamide, glycine, proline, BDDE, and lidocaine chlorhydrate 3%.

Results

The effect on the upward rotation of the tip nose was evaluated using Global Aesthetic Improvement Scale and morphometric evaluation. All the subjects showed at least 2–3 grade improvement in GAIS score after HA filler injection. The analysis of patient satisfaction after the last follow-up visits clearly demonstrated good results. A significant morphometric difference was detected comparing the T0 and T90 (p<0,0001), while no difference was present comparing T90 and T180 means (p=0.11).

The outcome of the present clinical study gives greater projection and upper rotation to the tip with great gratification of the patients and the surgeon. An augmentation of the tip nose with hyaluronic acid filler produces a rejuvenation of the nose area resulted in a more youthful appearance. No adverse event was observed. In 35 patients, additional HA infiltration had to be performed after 2 weeks.

Conclusion

In conclusion, the Italian technique descripted in the present paper is safe, simply, and efficacious for rejuvenation of the nose, with elevated levels of patient satisfaction.

Level of Evidence II

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Dyskeratosis congenita associated with a novel missense variant in TERT: Approach for the dermatologists
Authors: Neri Morales Constanza , Cuestas Daniel , Ángel Felipe , Ilelaty Urbano Felipe A. , Rodríguez Paula Andrea , Brito José Abraham , Téllez Daniel , Fernández Isabel , Celis Regalado Luis
Published: June 2024

Dyskeratosis congenita (DC) is a telomeropathy presenting diagnostic and therapeutic challenges across multiple specialties; yet, subtle dermatological signs enable early detection, altering patient prognosis. A specific DC genetic sequencing was performed according to the clinical criteria of our patient in study. Subsequently, cross-checked information in the main genetic databases was carried out. Additionally, an extensive review of the literature was made to organize the main dermatological aspects in DC. We report a novel variant of DC. Additionally, we share 10 useful and practical messages for dermatologists and any specialist caring for this group of patients.
Propriety of various examinations for subjective symptoms of olfactory disorders
Authors: Hemmi Tomotaka , Nomura Kazuhiro , Kobayashi Yuta , Numano Yuki , Ikeda Ryoukichi , Sugawara Mitsuru
Published: June 2024

Purpose

In Japan, two types of tests for diagnosing olfactory disorders, T and T (T&T) olfactometry and intravenous olfactory tests, are covered by insurance and performed on patients with olfactory disorders. This study examined the validity of these olfactory tests and whether psychophysical or morphological tests are more helpful in evaluating olfactory disorders.

Methods

We evaluated patients who visited our department and underwent two types of olfaction tests and sinus computed tomography (CT). Data regarding the age, sex, peripheral blood eosinophil percentage, presence of bronchial asthma, diagnoses, olfactory symptom score, results of the two olfactory tests, and CT findings in eligible patients were extracted from medical records and retrospectively reviewed.

Results

One hundred and sixty-three patients underwent all tests during the study period. The results of the T&T olfactometry and intravenous olfactory tests were significantly correlated. However, only the results of T&T olfactometry and olfactory cleft opacification on CT were statistically significant predictors of the olfactory symptom scores.

Conclusion

T&T olfactometry and CT evaluations of olfactory cleft opacification helped evaluate olfactory dysfunction. It is important to note that intravenous olfactory tests are best performed with careful control and not blindly to assess olfactory disorders.
Imagery and motor learning: a special issue on the neurocognitive mechanisms of imagery and imagery practice of motor actions
Authors: Frank Cornelia , Guillot Aymeric , Vogt Stefan
Published: June 2024

Human beings are able to imagine actions with the aim to change movement coordination and to learn particular movements. Meta-analyses to date have shown that when individuals systematically engage in imagery of a motor action without overt behavior this can improve motor performance and facilitate motor learning. Despite a considerable body of research in neuroscience, psychology, and sport science, however, there is at present no consensus on the neurocognitive mechanisms of imagery, and the mechanisms that lead to learning via imagined action are still being debated. In particular, the differences between imagined and overt action, and respective learning effects, remain to be fully explained. The present collection of manuscripts is a result of compiling both theoretical advances in the field of motor control and motor learning and those in imagery research to better understand imagery and learning. It is structured alongside five position papers from leading experts in the field, each of which is followed by a series of short commentaries written by experts from various disciplines. This collection demonstrates (a) that conceptualizations of imagery are manifold, vary highly and depend on the perspective chosen, (b) that existing approaches to the neurocognitive mechanisms of imagery and imagery practice of motor actions draw on distinct motor control and learning perspectives, (c) that perspectives from the wider fields of motor control and learning stimulate new approaches to explain imagery and imagery practice, (d) and that future research is needed to investigate and compare different perspectives and conceptualizations of the neurocognitive mechanisms of imagery and imagery practice of motor actions.
The interplay between ego-resiliency, math anxiety and working memory in math achievement
Authors: Doz Eleonora , Cuder Alessandro , Pellizzoni Sandra , Granello Federica , Passolunghi Maria Chiara
Published: June 2024

Previous research has suggested that math anxiety may contribute to poor math performance by interfering with working memory. However, only a limited number of studies investigated the mediating role of working memory in the math anxiety-math performance link in school-aged children. Unlike math anxiety, ego-resiliency is a personality resource that promotes the management of challenges and has been positively associated with math performance and negatively with anxiety. Nevertheless, there is still limited understanding regarding the specific role of ego-resiliency in math learning and how it relates to math anxiety. This study aimed to investigate conjunctly the interplay between primary school children’s ego-resiliency, math anxiety, working memory, and performance on two different math tasks (i.e., arithmetic task and word problem-solving task), after controlling for general anxiety and age. The study involved 185 Italian children from grades 3 to 5. Serial multi-mediational analyses revealed that: (1) ego-resiliency has a positive indirect effect on math achievement through two paths - math anxiety, and math anxiety and working memory; (2) the study replicated previous findings showing that working memory partially mediated the relationship between math anxiety and math performance; (3) similar patterns of results were found for both math skills. The study identifies ego-resiliency as a possible protective factor in the development of math anxiety and suggests that ego-resiliency could be worth considering when designing interventions aimed at reducing negative emotions towards mathematics.
Interdisciplinary assessment and treatment of paediatric drooling: two decades of experience by the Nijmegen saliva control team reflected in a stepwise algorithm
Authors: Orriëns Lynn B. , de Groot Sandra A. F. , van der Burg Jan J. W. , van den Hoogen Frank J. A. , van Hulst Karen , Erasmus Corrie E.
Published: June 2024

Anterior and posterior drooling are prevalent comorbidities in children with neurodevelopmental disabilities. Considering the heterogeneity of the patient population and the multifactorial aetiology of drooling, an interdisciplinary and individualised treatment approach is indispensable. However, no tool for stepwise decision-making in the treatment of paediatric drooling has been developed previously. Within the Radboudumc Amalia Children’s Hospital, care for children with anterior and/or posterior drooling secondary to neurodevelopmental disabilities is coordinated by a saliva control team with healthcare professionals from six disciplines. In alignment with international literature, published guidelines, and evidence gained from two decades of experience and research by our team, this paper proposes an algorithm reflecting the assessment and treatment approach applied in our clinic. First, directions are provided to decide on the necessity of saliva control treatment, taking type of drooling, the child’s age, and the severity and impact of drooling into account. Second, the algorithm offers guidance on the choice between available treatment options, highlighting the importance of accounting for child characteristics and child and caregiver preferences in clinical (shared) decision-making.

Conclusions: With this algorithm, we aim to emphasise the importance of repeated stepwise decision-making in the assessment and treatment of drooling in children during their childhood, encouraging healthcare professionals to apply a holistic approach.

What is Known:• Children with anterior or posterior drooling secondary to neurodevelopmental disabilities comprise a heterogeneous group, necessitating an individualised treatment approach.• No stepwise decision-making tool is available for the treatment of paediatric drooling.

What is New:• Deciding on the necessity of saliva control treatment should be a conscious process, based on type of drooling, age, and drooling severity and impact.• Type of drooling, age, cognition, oral motor skills, self-awareness, posture, diagnosis, and child/caregiver preferences need to be considered to decide on the optimal treatment.
Efficacy and safety of belimumab combined with the standard regimen in treating children with lupus nephritis
Authors: Li Huarong , Chen Chaoying , Yang Hongxian , Tu Juan
Published: June 2024

The purpose of this study is to evaluate the efficacy and safety of belimumab combined with the standard regimen in treating children with active lupus nephritis. This single-center, retrospective cohort study used clinical data of children with newly active lupus nephritis hospitalized in the Department of Nephrology between December 2004 and February 2023. Patients were divided into a belimumab or traditional treatment group according to whether or not they received belimumab. Renal remission and recurrence rates and glucocorticoid dose were compared between groups. Forty-seven children (median age 11 years) were enrolled, including 30 and 17 children in the traditional treatment and belimumab groups, respectively. The Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2000) score of children in the belimumab group (23.59 ± 7.78) was higher than that in the traditional treatment group (19.13 ± 6.10) (P = 0.035). The two groups showed no significant difference in the frequency of pyuria, gross hematuria, and the levels of 24-h proteinuria and estimated glomerular filtration rate. The complement C3/C4 in the belimumab group recovered faster than that in the traditional treatment group (P < 0.05). There were no between-group differences in the complete renal remission rate at 6 or 12 months (P = 0.442, P = 0.759). There were no between-group differences in 1-year recurrence rate (P = 0.303). Furthermore, 6 and 12 months after treatment, glucocorticoid doses were lower in the belimumab than the traditional treatment group (17.87 ± 6.96 mg/d vs. 27.33 ± 8.40 mg/d, P = 0.000; 10.00 (5.3) mg/d vs. 13.75 (10.0) mg/d, P = 0.007), respectively.

Conclusion

With an equivalent renal remission rate, belimumab combined with the standard traditional regimen might promote the tapering of glucocorticoids, and the incidence of adverse events is low.

What is known:

• Belimumab is documented as an adjunctive treatment with systemic lupus erythematosus (c-SLE) LN with efficacy.• Due to the paucity of studies, its effects and side effects in children with LN remain unclear.

What is new:

• This single-center, retrospective cohort study evaluated the efficacy and safety of belimumab combined with the standard regimen in treating children with proliferative LN.• Belimumab combined with the standard traditional treatment might promote the tapering of glucocorticoids, while exhibiting a low occurrence of adverse events.
EAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults
Authors: Keller Deborah S. , Curtis Nathan , Burt Holly Ann , Ammirati Carlo Alberto , Collings Amelia T. , Polk Hiram C. , Carrano Francesco Maria , Antoniou Stavros A. , Hanna Nader , Piotet Laure-Meline , Hill Sarah , Cuijpers Anne C. M. , Tejedor Patricia , Milone Marco , Andriopoulou Eleni , Kontovounisios Christos , Leeds Ira L. , Awad Ziad T. , Barber Meghan Wandtke , Al-Mansour Mazen , Nassif George , West Malcolm A. , Pryor Aurora D. , Carli Franco , Demartines Nicholas , Bouvy Nicole D. , Passera Roberto , Arezzo Alberto , Francis Nader
Published: June 2024

Background

As the population ages, more older adults are presenting for surgery. Age-related declines in physiological reserve and functional capacity can result in frailty and poor outcomes after surgery. Hence, optimizing perioperative care in older patients is imperative. Enhanced Recovery After Surgery (ERAS) pathways and Minimally Invasive Surgery (MIS) may influence surgical outcomes, but current use and impact on older adults patients is unknown. The aim of this study was to provide evidence-based recommendations on perioperative care of older adults undergoing major abdominal surgery.

Methods

Expert consensus determined working definitions for key terms and metrics related to perioperative care. A systematic literature review and meta-analysis was performed using the PubMed, Embase, Cochrane Library, and Clinicaltrials.gov databases for 24 pre-defined key questions in the topic areas of prehabilitation, MIS, and ERAS in major abdominal surgery (colorectal, upper gastrointestinal (UGI), Hernia, and hepatopancreatic biliary (HPB)) to generate evidence-based recommendations following the GRADE methodology.

Result

Older adults were defined as 65 years and older. Over 20,000 articles were initially retrieved from search parameters. Evidence synthesis was performed across the three topic areas from 172 studies, with meta-analyses conducted for MIS and ERAS topics. The use of MIS and ERAS was recommended for older adult patients particularly when undergoing colorectal surgery. Expert opinion recommended prehabilitation, cessation of smoking and alcohol, and correction of anemia in all colorectal, UGI, Hernia, and HPB procedures in older adults. All recommendations were conditional, with low to very low certainty of evidence, with the exception of ERAS program in colorectal surgery.

Conclusions

MIS and ERAS are recommended in older adults undergoing major abdominal surgery, with evidence supporting use in colorectal surgery. Though expert opinion supported prehabilitation, there is insufficient evidence supporting use. This work has identified evidence gaps for further studies to optimize older adults undergoing major abdominal surgery.
Seasonal coordination of aboveground vegetative and reproductive growth and storage in apple trees subjected to defoliation, flower and fruit thinning
Authors: Plavcová Lenka , Jupa Radek , Hoch Günter , Mészáros Martin , Scháňková Klára
Published: June 2024

Key message

The growth rates of current-year shoots, fruits and trunks in apple trees peak sequentially during the growing season. The period of most intense growth coincided with the lowest NSC reserves.

Vegetative and reproductive growth and storage are major carbon sinks in fruit trees; however, little is known about their mutual seasonal coordination. In this study, we monitored growth dynamics of trunks, fruits and current-year shoots together with the concentration of non-structural carbohydrates (NSC) in trees subjected to defoliation, early season flower thinning, mid-season fruit thinning and their respective combinations across the season. We found that defoliation had a negative effect on both trunk radial growth and annual fruit yield. Flower and fruit thinning caused lower fruit number per tree, but the individual fruits were larger resulting in a similar annual fruit yield among the treatments. Shoot extension growth was not significantly affected by the defoliation and flower and fruit thinning treatments. The concentration of non-structural carbohydrates was also similar across treatments. Modelled daily growth rates of shoots, fruits and trunks peaked sequentially one after another throughout the growing season with a delay of 15 and 18 days, respectively. The period of most intense growth of tree’s organs corresponded well with the lowest NSC reserves and a temporary depletion of starch in 1-year-old branches. Taken together, our study illustrates a tight temporal coordination of major carbon sinks and improves our understanding of sink/source relations of commercially important apple trees.
Calculation of the minimum clinically important difference (MCID) using different methodologies: case study and practical guide
Authors: Klukowska Anita M. , Vandertop W. Peter , Schröder Marc L. , Staartjes Victor E.
Published: June 2024

Introduction

Establishing thresholds of change that are actually meaningful for the patient in an outcome measurement instrument is paramount. This concept is called the minimum clinically important difference (MCID). We summarize available MCID calculation methods relevant to spine surgery, and outline key considerations, followed by a step-by-step working example of how MCID can be calculated, using publicly available data, to enable the readers to follow the calculations themselves.

Methods

Thirteen MCID calculations methods were summarized, including anchor-based methods, distribution-based methods, Reliable Change Index, 30% Reduction from Baseline, Social Comparison Approach and the Delphi method. All methods, except the latter two, were used to calculate MCID for improvement of Zurich Claudication Questionnaire (ZCQ) Symptom Severity of patients with lumbar spinal stenosis. Numeric Rating Scale for Leg Pain and Japanese Orthopaedic Association Back Pain Evaluation Questionnaire Walking Ability domain were used as anchors.

Results

The MCID for improvement of ZCQ Symptom Severity ranged from 0.8 to 5.1. On average, distribution-based methods yielded lower MCID values, than anchor-based methods. The percentage of patients who achieved the calculated MCID threshold ranged from 9.5% to 61.9%.

Conclusions

MCID calculations are encouraged in spinal research to evaluate treatment success. Anchor-based methods, relying on scales assessing patient preferences, continue to be the “gold-standard” with receiver operating characteristic curve approach being optimal. In their absence, the minimum detectable change approach is acceptable. The provided explanation and step-by-step example of MCID calculations with statistical code and publicly available data can act as guidance in planning future MCID calculation studies.
Nonlinear poro-thermo-forced vibration in curved sandwich magneto-electro-elastic shells under hygrothermal environment
Authors: Selvamani Rajendran , Ebrahimi Farzad , Yaylacı Murat , Öztürk Şevval , Yaylacı Ecren Uzun
Published: June 2024

This research employs a multiple scales perturbation approach to evaluate the nonlinear wave propagation behaviors of a doubly curved sandwich composite piezoelectric shell with a flexible core in a hygrothermal environment. Stress and strain calculations for the flexible core and face sheets are carried out using Reddy's third-order shear deformation theory (TSDT) and third-order polynomial theory, respectively. The study explores the synergistic effects of a multilayered shell, flexible core, and magneto-rheological layer (MR) in revealing the nonlinearity of both in-plane and vertical moment within the core. The Halpin–Tsai model is employed to derive the properties of polymer/carbon nanotube/fiber (PCF) and polymer/graphene platelet/fiber (PGF) three-phase composite shells. The governing equations for the multiscale shell are derived using Hamilton's formulation. The research investigates temperature variations, diverse distribution patterns, curvature ratios, and magnetic fields through numerical analysis, presenting the results graphically and prior research has demonstrated the accuracy of these methods. Notably, these factors exert significant influence on the frequency-amplitude curves of the smart structure.
Rosmarinus officinalis L. essential oil enhances salt stress tolerance of durum wheat seedlings through ROS detoxification and stimulation of antioxidant defense
Authors: Ben Saad Rania , Ben Romdhane Walid , Wiszniewska Alina , Baazaoui Narjes , Taieb Bouteraa Mohamed , Chouaibi Yosra , Alfaifi Mohammad Y. , Kačániová Miroslava , Čmiková Natália , Ben Hsouna Anis , Garzoli Stefania
Published: June 2024

Salt-induced stress poses a significant barrier to agricultural productivity by impeding crop growth. Presently, environmentalists are dedicated to safeguarding food security by enhancing agricultural yields in challenging environments. Biostimulants play a crucial role in mitigating abiotic stresses in crop production, and among these, plant essential oils (EOs) stand out as organic substances with diverse biological effects on living organisms. Among the natural promoters of plant growth, Rosmarinus officinalis L. essential oil (RoEO) has gained considerable attention. Although the manifold effects of essential oils (EOs) on plant growth have been extensively demonstrated, their impact on salt stress tolerance in durum wheat seedlings remains unexplored. This investigation was undertaken to evaluate the biostimulatory capabilities of RoEO on the durum wheat cultivar “Mahmoudi.” The effects of three RoEO concentrations (1, 2.5, and 5 ppm) on seed germination, growth establishment, and the induction of salt resistance under salinity conditions (150 mM NaCl) were tested. At 5 ppm, RoEO enhanced seedlings’ tolerance to salinity by improving growth and reducing membrane deterioration and oxidative stress-induced damage. The expression profile analyses of seven stress-related genes (TdNHX1, TdSOS1, TdSOD, TdCAT, TdGA20-ox1, TdNRT2.1, and TdGS) using RT-qPCR showed enhancement of several important genes in durum wheat seedlings treated with 5 ppm RoEO, even under control conditions, which may be related to salt stress tolerance. The results indicate that the application of RoEO suggests a possible alternative strategy to increase salt tolerance in durum wheat seedlings towards better growth quality, thus increasing ROS scavenging and activation of antioxidant defense.
Outcomes after gastrectomy according to the Gastrectomy Complications Consensus Group (GCCG) in the Dutch Upper GI Cancer Audit (DUCA)
Authors: Visser Maurits R. , Voeten Daan M. , Gisbertz Suzanne S. , Ruurda Jelle. P. , van Berge Henegouwen Mark I. , van Hillegersberg Richard ,   the Dutch Upper Gastrointestinal Cancer Audit (DUCA) Group
Published: June 2024

Background

In 2019, the Gastrectomy Complications Consensus Group (GCCG) published a standardized set of complications aiming toward uniform reporting of post-gastrectomy complications. This study aimed to report outcomes after gastrectomy in the Netherlands according to GCCG definitions and compare them to previously reported national results and the European database reported by the GCCG.

Methods

This nationwide, population-based cohort study included all patients undergoing gastrectomy for gastric cancer registered in the DUCA in 2020–2021. Postoperative morbidity and 30-day/in-hospital mortality were analyzed according to the GCCG definitions. For all patients, baseline characteristics and outcomes were compared with the GCCG cohort consisting of 27 European expert centers (GASTRODATA; 2017–2018).

Results

In 2020–2021, 782 patients underwent gastrectomy in the Netherlands. Variation was seen in baseline characteristics between the Dutch and the GCCG cohort (N = 1349), most notably in minimally invasive surgery (80.6% vs 19.6%, p < 0.001). In the Netherlands, 223 (28.5%) patients developed a total of 407 complications, the most frequent being non-surgical infections (28.5%) and anastomotic leakage (13.4%). The overall complication and 30-day mortality rates were similar between the Dutch and GCCG cohort (28.5% vs 29.8%, p = 0.563; 3.7% vs 3.6%, p = 0.953). Higher surgical and endoscopic/radiologic reintervention rates were observed in the Netherlands compared to the GCCG cohort (10.7% vs 7.8%, p = 0.025; 10.9% vs 2.9%, p < 0.001).

Conclusion

Reporting outcomes according to the standardized GCCG definitions allows for international benchmarking. Postoperative outcomes were comparable between Dutch and GCCG cohorts, but both exceed the international benchmark for expert gastrectomy care, highlighting targets for national and international quality improvement.
A New Investigation to Discriminate Sexes in Alive Nile Tilapia (Oreochromis niloticus) Using Cyp19a1a and Dmrt1 Gene Expression in Tail Fin Tissues
Authors: El-Zaeem Samy Y. , El-Hanafy Amr , El-Dahhar Alaa A. , Elmaghraby Ayaat M. , Hendy Amany M.
Published: June 2024

The Nile Tilapia (Oreochromis niloticus), a gonochoristic teleost fish with a XX/XY sex-determination system, is an ideal model for investigating gonadal sex differentiation. During gonadal differentiation, the expression of cyp19a1a in XX gonads and dmrt1 in XY gonads are required for undifferentiated tissues to develop into ovary or testis. In this study, quantitative real-time RT-PCR assessed the expression of cyp19a1a and dmrt1 genes in gonads and tail fin tissues. Differences in gene expression mean among sexually differentiated fish were analyzed using two-way analysis of variance (ANOVA) and validation of mixed model using discriminant analysis (DA) for morphometric traits and the gene expression in gonads and tail fin tissues used to validate and utilize them in discriminating sexes in sex-differentiated Nile Tilapia fish. The results revealed that, cyp19a1a gene expression in female ovaries was more significant than dmrt1 in male testis. In the other hand, the dmrt1 gene expression in the tail fin was higher in males than females. Both, cyp19a1a and dmrt1 genes, can discriminate fish sexes by 100% by using their expression in tail fin tissues. In conclusion, the cyp19a1a and dmrt1 genes could be used as a genetic marker to discriminate between the Nile Tilapia sexes, whereas used as an indicator for ovarian or testis differentiation in sexually differentiated Nile Tilapia using tail fin tissues. It is worth mentioning that this is the first investigation for using cyp19a1a and dmrt1 genes from Nile Tilapia tail fin tissues in sex determination.