bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling the Rising Tails of Galaxy Rotation Curves
Authors: Zhang Fan
Published: January 2019

It is well known, but under-appreciated in astrophysical applications, that it is possible for gravity to take on a life of its own in the form of Weyl-curvature-only metrics (note that we are referring to the Weyl-only solutions of ordinary General Relativity; we are not considering Weyl conformal gravity or any other modified gravity theories), as numerous examples demonstrate the existence of gravitational fields not being sourced by any matter. In the weak field limit, such autonomous gravitational contents of our universe manifest as solutions to the homogeneous Poisson’s equation. In this note, we tentatively explore the possibility that they may perhaps account for some phenomenologies commonly attributed to dark matter. Specifically, we show that a very simple solution of this kind exists that can be utilized to describe the rising tails seen in many galaxy rotation curves, which had been difficult to reconcile within the cold dark matter or modified Newtonian dynamics frameworks. This solution may also help explain the universal ∼1 Gyr rotation periods of galaxies in the local universe.
Assessment of the Potential Pollution of the Abidjan Unconfined Aquifer by Hydrocarbons
Authors: Kouamé Amenan Agnès , Jaboyedoff Michel , Goula Bi Tie Albert , Derron Marc-Henri , Kouamé Kan Jean , Meier Cédric
Published: January 2019

A study of the unconfined Continental Terminal aquifer in Abidjan District, located in a coastal sedimentary basin in Southern Côte d’Ivoire (West Africa), is conducted. This aquifer is the principal source of drinking water for the city of Abidjan. The water quality of the aquifer is affected by anthropogenic sources of pollution, such as scattered deposits of solid and liquid waste of all kinds. Additionally, the proliferation of gas stations, including potential tank leakage, must be considered in the event of an accident. To ensure the effective protection and management of the Abidjan groundwater, this work assesses the groundwater contamination risk of the Abidjan aquifer by hydrocarbons such as benzene. To achieve this objective, a numerical groundwater model that included the geological and hydrogeological data of the Abidjan aquifer was constructed with FEFLOW 7.1. A predictive simulation of groundwater flow coupled with the transport of dissolved benzene deposited on the soil surface at the N’Dotré and Anador gas stations was performed. The initial concentrations of dissolved benzene were 43.12 mg/L and 14.17 mg/L at the N’Dotré and Anador sites, respectively. The results revealed that a threshold concentration of 0.001 mg/L was reached after 44 years and two months at borehole ZE11, which is located four kilometers downgradient from the source. The maximum peak concentration of 0.011 mg/L was reached at this point after 47 years and two months. In this region, 14 other boreholes could be threatened by dissolved benzene pollution based on the simulation.
Documentation: A Security Tool for the Identification and Repatriation of Illicitly Trafficked Objects from Museums with Particular Reference to the National Gallery of Zimbabwe
Authors: Chiwara Davison
Published: January 2019

The aim of the study was to ascertain how documentation assisted in the recovery of stolen and illicitly trafficked objects at the National Gallery of Zimbabwe. The research objectives were to: Assess the adequacy of the gallery’s documentation system; appraise the documentation elements that were key in the tracking and repatriation of stolen objects to the gallery; analyze the gallery’s networks on the documentation and safeguarding of objects against theft; and ascertain challenges faced by the gallery in documenting its objects. Research results indicated that the gallery’s documentation system encompassed both manual and electronic documentation, which addressed vital aspects that have been prescribed by Object ID Standards for the identification and recovery of stolen objects. These include photographs, provenance, and name of objects. This, coupled with networks with key institutions involved in the fight against theft and illicit trafficking of objects, has enabled the gallery to recover its stolen objects from Poland. However, lack of state-of-the-art cameras has led to the production of poor photographs, which compromised the gallery’s claim to its stolen objects. Additionally, lack of ideal software for the gallery’s database is hampering effective documentation efforts. The research recommends that the gallery should acquire appropriate cameras for quality documentation of its objects and purchase database software with backup support for software upgrades to prevent loss of information on its objects.
Occupational Exposures and Neurodegenerative Diseases—A Systematic Literature Review and Meta-Analyses
Authors: Gunnarsson Lars-Gunnar , Bodin Lennart
Published: January 2019

Objectives: To carry out an integrated and stratified meta-analysis on occupational exposure to electromagnetic fields (EMFs), metals and pesticides and its effects on amyotrophic lateral sclerosis (ALS) and Parkinson’s and Alzheimer’s disease, and investigate the possibility of publication bias. Methods: In the current study, we updated our recently published meta-analyses on occupational exposures in relation to ALS, Alzheimer’s and Parkinson’s disease. Based on 66 original publications of good scientific epidemiological standard, according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guidelines, we analysed subgroups by carrying out stratified meta-analyses on publication year, statistical precision of the relative risk (RR) estimates, inspection of the funnel plots and test of bias. Results: Based on 19 studies the weighted RR for occupational exposure to EMFs was 1.26 (95% confidence interval (CI) 1.07–1.50) for ALS, 1.33 (95% CI 1.07–1.64) for Alzheimer’s disease and 1.02 (95% CI 0.83–1.26) for Parkinson’s disease. Thirty-one studies concerned occupational exposure to pesticides and the weighted RR was 1.35 (95% CI 1.02–1.79) for ALS, 1.50 (95% CI 0.98–2.29) for Alzheimer’s disease and 1.66 (95% CI 1.42–1.94) for Parkinson’s disease. Finally, 14 studies concerned occupational exposure to metals and only exposure to lead (five studies) involved an elevated risk for ALS or Parkinson’s disease and the weighted RR was 1.57 (95% CI 1.11–2.20). The weighted RR for all the non-lead exposures was 0.97 (95% CI 0.88–1.06). Conclusions: Exposure to pesticides increased the risk of getting the mentioned neurodegenerative diseases by at least 50%. Exposure to lead was only studied for ALS and Parkinson’s disease and involved 50% increased risk. Occupational exposure to EMFs seemed to involve some 10% increase in risk for ALS and Alzheimer’s disease only.
Poisson-Gamma Mixture Spatially Varying Coefficient Modeling of Small-Area Intestinal Parasites Infection
Authors: Osei Frank Badu , Stein Alfred , Ofosu Anthony
Published: January 2019

Understanding the spatially varying effects of demographic factors on the spatio-temporal variation of intestinal parasites infections is important for public health intervention and monitoring. This paper presents a hierarchical Bayesian spatially varying coefficient model to evaluate the effects demographic factors on intestinal parasites morbidities in Ghana. The modeling relied on morbidity data collected by the District Health Information Management Systems. We developed Poisson and Poisson-gamma spatially varying coefficient models. We used the demographic factors, unsafe drinking water, unsafe toilet, and unsafe liquid waste disposal as model covariates. The models were fitted using the integrated nested Laplace approximations (INLA). The overall risk of intestinal parasites infection was estimated to be 10.9 per 100 people with a wide spatial variation in the district-specific posterior risk estimates. Substantial spatial variation of increasing multiplicative effects of unsafe drinking water, unsafe toilet, and unsafe liquid waste disposal occurs on the variation of intestinal parasites risk. The structured residual spatial variation widely dominates the unstructured component, suggesting that the unaccounted-for risk factors are spatially continuous in nature. The study concludes that both the spatial distribution of the posterior risk and the associated exceedance probability maps are essential for monitoring and control of intestinal parasites.
Analysis of the Prediction of Motivational Climate in Handball Players’ Fear of Failure
Authors: Gómez-López Manuel , Ruiz-Sánchez Victoria , Granero-Gallegos Antonio
Published: January 2019

Sports can at times become a negative socializing agent for athletes. The objectives here were to analyse the relationship between motivational climates (involving coaches and peers) and fear of failure in players according to gender and sports experience, and also to control for the extent to which these motivational climates predict the different aversive causes of fear of failure. To this aim, a non-experimental, descriptive, and sectional design was used in which participants answered the Perceived Motivational Climate in Sport Questionnaire, the Peer Motivational Climate in Youth Sports Questionnaire, and the Performance Failure Appraisal Inventory. The sample included 479 handball players aged 16–17 years old (mean = 16.60; standard deviation = 0.50) who were playing in Spanish regional youth category handball teams. The results revealed that the task-involving training climate predominates in both genders over the ego-involving training climate, particularly in girls and in less experienced players. The peer ego-involving climate also predominates with respect to the peer task-involving climate in both genders, but this is particularly so for boys and in more experienced players. Furthermore, except for fear of feeling shame, which was predicted by the peer ego-involving climate, all the aversive causes of fear of failure are predicted mainly by the coach climate. The immediate environment was proved to be determinant in avoidance behaviours and fear of failure.
Development and Validation of Positive Smoker Identity Questionnaire (PSmoQi): A New Instrument for Smoking Cessation Correlates
Authors: Ahmad Mohd Hanief , Ibrahim Mohd Ismail , Ab Rahman Azriani , Musa Kamarul Imran , Mohd Zin Faridah , Mohd Zain Rehanah , Hasan Ruhaya , Hassan Noraryana , Ahmad Imran , Idris Nur Suhaila
Published: January 2019

Background: The positive smoker identity construct, which was based on West’s PRIME Theory, affected the smoking prevalence, quit attempts and cessation success. A validated questionnaire which could measure this rich and complex construct may facilitate prediction models of successful cessation. We aimed to develop and validate a questionnaire that assesses positive smoker identity based on West’s PRIME Theory. Method: The initial item pool was developed based on a theoretical framework, empirical literature, existing scales and expert review. The questionnaire was conveniently distributed to 100 smokers. Exploratory factor analysis was utilized to explore domains in the questionnaire. Construct and criterion validity, internal consistency and reliability of the domains were analyzed. Results: The final positive smoker identity questionnaire (PSmoQi) has 26 items under four internally-consistent and reliable domains: Contributory factors, contextual and temporal patterning, identity related to smoking, and behaviour in relation to smoking. The full scale demonstrated good internal consistency (∝ = 0.78), acceptable convergent and divergent validity, and good concurrent validity with the smoker self-concept scale. Conclusion: The current study provides fundamental evidence for the PSmoQi as a valid instrument in research related to smoking cessation and interventional strategy. The PSmoQi contained validated domains which could measure almost a full spectrum of smoking cessation components.
The Status of Occupational Stress and Its Influence the Quality of Life of Copper-Nickel Miners in Xinjiang, China
Authors: Li Yuhua , Sun Xuemei , Ge Hua , Liu Jiwen , Chen Lizhang
Published: January 2019

The purpose of this study was to investigate the status of occupational stress and its influence on the quality of life of copper-nickel miners, in order to provide a theoretical basis for alleviating occupational stress to improve their quality of life. Stratified cluster sampling and a self-administered questionnaire survey were used. The Effort–Reward Imbalance (ERI) questionnaire and the SF-36 (36-Item Short Form) health survey scale were administered to all 2000 miners registered with a copper-nickel mining human resources department and who had been on duty for more than one year. In total, 1857 valid questionnaires were collected, with a response rate of 92.85%. The percentage of the copper-nickel miners suffering from occupational stress was 42.65%. A statistically significant difference was observed in relation to the prevalence of occupational stress among miners of different genders, ages, education levels, and operating units. The occupational stress detection rate was higher for males than females. Miners aged between 30 and 34 years exhibited the highest level of occupational stress compared to other age groups. Those with a junior college education exhibited the highest rate of occupational stress compared to those with other levels of education. Those working in the smelting unit exhibited the highest rate of occupational stress compared to those working in other operational units. Those classified as experiencing stress (an ERI score >1) had lower quality of life scores than miners classified as not experiencing stress (an ERI score ≤1). The results show that level of education, monthly income, and degree of occupational stress affect quality of life among copper-nickel miners. It was found that older age, lower income, higher education level, and higher degree of occupational stress were factors related to poorer quality of life. Copper-nickel miners have high levels of occupational stress, and occupational stress is a risk factor that can diminish quality of life.
Interactive Effects between Chronic Lead Exposure and the Homeostatic Iron Regulator Transport HFE Polymorphism on the Human Red Blood Cell Mean Corpuscular Volume (MCV)
Authors: Chen Chien-Juan , Lin Ting-Yi , Wang Chao-Ling , Ho Chi-Kung , Chuang Hung-Yi , Yu Hsin-Su
Published: January 2019

Research has shown that long-term exposure to lead harms the hematological system. The homeostatic iron regulator HFE (hemochromatosis) mutation, which has been shown to affect iron absorption and iron overload, is hypothesized to be related to lead intoxication in vulnerable individuals. The aim of our study was to investigate whether the HFE genotype modifies the blood lead levels that affect the distributions of serum iron and other red blood cell indices. Overall, 121 lead workers and 117 unexposed age-matched subjects were recruited for the study. The collected data included the blood lead levels, complete blood count, serum iron, total iron binding capacity, transferrin, and ferritin, which were measured during regular physical examinations. All subjects filled out questionnaires that included demographic information, medical history, and alcohol and tobacco consumption. HFE genotyping for C282Y and H63D was determined using polymerase chain reaction and restriction fragment length polymorphism (PCR/RFLP). The mean blood lead level in lead workers was 19.75 µg/dL and was 2.86 µg/dL in unexposed subjects. Of 238 subjects, 221 (92.9%) subjects were wild-type (CCHH) for HFE C282Y and H63D, and 17 (7.1%) subjects were heterozygous for a H63D mutation (CCHD). Multiple linear regression analysis showed that blood lead was significantly negatively associated with hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular volume (MCV), whereas the HFE variant was associated negatively with MCV and positively with ferritin. An interactive influence on MCV was identified between blood lead and HFE variants. Our research found a significant modifying effect of the HFE variant, which possibly affected MCV. The HFE H63D heterozygous (CCHD) variant seemed to provide a protective factor against lead toxicity. Future studies should focus on competing binding proteins between iron and lead influenced by gene variation.
Combining Spatial Analysis and a Drinking Water Quality Index to Evaluate Monitoring Data
Authors: Li Hongxing , Smith Charlotte D. , Wang Li , Li Zheng , Xiong Chuanlong , Zhang Rong
Published: January 2019

Drinking water monitoring is essential for identifying health-related risks, as well as for building foundations for management of safe drinking water supplies. However, statistical analyses of drinking water quality monitoring data are challenging because of non-normal (skewed distributions) and missing values. Therefore, a new method combining a water quality index (WQI) with spatial analysis is introduced in this paper to fill the gap between data collection and data analysis. Water constituent concentrations in different seasons and from different water sources were compared based on WQIs. To generate a WQI map covering all of the study areas, predicted WQI values were created for locations in the study area based on spatial interpolation from nearby observed values. The accuracy value of predicted and measured values of our method was 0.99, indicating good predication performance. Overall, the results of this study indicate that this method will help fill the gap between the collection of large amounts of drinking water data and data analysis for drinking water monitoring and process control.
The Hydraulic Driving Mechanisms of Cyanobacteria Accumulation and the Effects of Flow Pattern on Ecological Restoration in Lake Dianchi Caohai
Authors: Zhang Peng , Liang Rui-Feng , Zhao Peng-Xiao , Liu Qing-Yuan , Li Yong , Wang Kai-Li , Li Ke-Feng , Liu Ying , Wang Peng
Published: January 2019

Due to rapid increases in socioeconomic development and the human population over the past few decades, the shallow lakes in China have suffered from eutrophication and poor water quality. The conditions in Lake Dianchi Caohai, which is in the northern part of Lake Dianchi, are considered the most serious. The ecological restoration of Lake Dianchi Caohai began in the late 1980s. Lake managers and the public have been puzzled by the lack of a significant response of the water quality to the flow pattern despite the tremendous investment in water quality improvements. Therefore, lake managers desperately need to understand the responses of pollutant behaviors to proposed management measures. In this paper, a depth-averaged two-dimensional hydrodynamic and water quality model based on hydrological data, measured lake bed elevation, and water quality data is developed to simulate the flow field and water quality of Lake Dianchi Caohai. This model was validated using water quality data from the Caohaizhongxin site in 2016, and a close agreement was found between the model results and observations. Wind-driven circulation in Lake Dianchi Caohai was observed in the model results, which revealed that the lake flow pattern was dominated by wind-driven circulation, while the inflow/outflow played only a subsidiary role during this period. The formation of the wind-driven current in Lake Dianchi Caohai could be roughly divided into three stages. The hydrodynamic processes connected with the distribution of chlorophyll a are evaluated and discussed to adequately understand the hydraulic mechanisms driving the accumulation of cyanobacteria. Moreover, we designed three scenarios after comparing all possible operation scenarios to analyze the contributions of each different operation scenario to the water quality improvements. The optimal ecological operation scenario which has the best impacts on the water quality, especially the reduction in Chla and NH3-N concentration, is proposed based on our comprehensive analysis. The water quality improvement and management suggestions proposed in this paper are based on lake flow patterns and make up for previous studies that did not consider the effects of hydraulic characteristics on water quality improvement in Lake Dianchi Caohai.
An Evaluation Model for Urban Comprehensive Carrying Capacity: An Empirical Case from Harbin City
Authors: Su Yikun , Xue Hong , Liang Huakang
Published: January 2019

Urbanization has brought notable benefits for cities, but has also resulted in severe and diverse challenges in China. Previous studies have contributed to the definitions and evaluation of urbanization. However, there remain a great deal of ambiguities regarding urban comprehensive carrying capacity, and its measurable indicators still need further exploration given the urban development. This study aims to explore a model for evaluating urban comprehensive carrying capacity and thus to promote urban development. A total of 48 indicators which fell into 8 subsystems were identified to evaluate the urban comprehensive carrying capacity through literature reviews and interviews. The indicator set was developed for evaluation indicator selecting. Meanwhile, the dynamic system was explored, and an evaluation model based on the entire array polygon method was designed to evaluate urban comprehensive carrying capacity. Finally, a case study was conducted to provide suggestions for the decision-maker to implement the evaluation model. The results of this study show that the evaluation indicator system was dynamic due to urban development. Meanwhile, the model of the entire array polygon method was able to effectively evaluate urban comprehensive carrying capacity through the case study. Furthermore, this study found that there is an imbalance among subsystems in urban development according to the standard deviation. The findings are useful for setting up a benchmark framework for urban sustainability and providing an evaluation and monitoring model for decision maker to improve the urban carrying capacity.
Understanding the Differing Impacts of On-Call Work for Males and Females: Results from an Online Survey
Authors: Roberts Bernadette , Vincent Grace E. , Ferguson Sally A. , Reynolds Amy C. , Jay Sarah M.
Published: January 2019

On-call work is prevalent worldwide and is associated with adverse outcomes, including disrupted sleep, impaired leisure time, and difficulties in mentally detaching from work. Limited studies specifically explored whether men and women experience on-call differently; therefore, our aim was to investigate whether sex differences exist in terms of both the impacts of and coping strategies to deal with on-call work. On-call workers (n = 228) participated in an online survey to investigate how on-call work impacts domestic, non-domestic, and leisure activities, and coping strategies. Pearson chi-squared analyses were used to determine sex differences for each construct of interest. Results indicated that female respondents were more likely to be responsible for running their household, and reported that being on call disturbed leisure, domestic, and non-domestic activities “a lot/very much”. While both males and females adopted engaged coping styles, a greater proportion of males used “problem solving” and a greater proportion of females “talked about their feelings” when managing on-call work. These findings provide valuable insight into how males and females are differentially impacted and cope with on-call work. Further research is required to better understand these impacts, particularly over time, and should include measures such as of quality of life, relationship satisfaction, and physical and mental health outcomes.
Understanding Potential Exposure of Bicyclists on Roadways to Traffic-Related Air Pollution: Findings from El Paso, Texas, Using Strava Metro Data
Authors: Lee Kyuhyun , Sener Ipek N.
Published: January 2019

As bicycling on roadways can cause adverse health effects, there is an urgent need to understand how bicycle routes expose bicyclists to traffic emissions. Limited resources for monitoring reveal that bicycle travel patterns may constrain such understanding at the network level. This study examined the potential exposure of bicyclists to traffic-related air pollution in El Paso, Texas, using Strava Metro data that revealed bicycle patterns across the city networks. An initial spatial mapping analysis was conducted to explore the spatial patterns of bicycling and traffic pollutant emission, followed by exploratory descriptive statistics. A spatial bicycle model was then developed to explore factors influencing bicycling activity in El Paso. Analysis results indicated significant associations between greater bicycle volume and both higher levels of particulate matter (PM2.5) emissions and more frequent bus services, implying adverse health concerns related to traffic-related air pollution. The results also indicated significant effects of various environmental characteristics (e.g., roadway, bicycle infrastructure, topography, and demographics) on bicycling. The findings encourage extending this study to provide guidance to bicyclists whose regular trips take place on heavily trafficked roads and during rush hours in this region and to evaluate the net health impacts of on-road bicycling for the general population.
Arsenic Distribution Assessment in a Residential Area Polluted with Mining Residues
Authors: Manjarrez-Domínguez Carlos B. , Prieto-Amparán Jesús A. , Valles-Aragón M. Cecilia , Delgado-Caballero M. Del Rosario , Alarcón-Herrera M. Teresa , Nevarez-Rodríguez Myrna C. , Vázquez-Quintero Griselda , Berzoza-Gaytan Cesar A.
Published: January 2019

Mining is a major source for metals and metalloids pollution, which could pose a risk for human health. In San Guillermo, Chihuahua, Mexico mining wastes are found adjacent to a residential area. A soil-surface sampling was performed, collecting 88 samples for arsenic determination by atomic absorption. Arsenic concentration data set was interpolated using the ArcGis models: inverse distance weighting (IDW), ordinary kriging (OK), and radial basis function (RBF). For method validation purposes, a set of the data was selected and two tests were performed (P1 and P2). In P1 the models were processed without the validation data; in P2 the validation data were removed one by one, models were processed every time that a data point was removed. An arsenic concentration range of 22.7 to 2190 mg/kg was reported. The 39% of data set was classified as contaminated soil and 61% as industrial land use. In P1 the method of interpolation with the lowest RMSE was RBF (0.80), the highest coefficient of E was RBF (46.25), and the highest Ceff value was with RBF (0.48). In P2 the method with the lowest RMSE was OK (0.76), the highest E value was 50.65 with OK, and the Ceff reported the highest value with OK (0.52). The high arsenic contamination in soil of the site indicates an abundant dispersion of this metalloid. Furthermore, the difference between the models was not very wide. The incorporation of more parameters would be of interest to observe the behavior of interpolation methods.
Effectiveness of a Large, Nation-Wide Smoking Abstinence Campaign in the Netherlands: A Longitudinal Study
Authors: Troelstra Sigrid A. , Harting Janneke , Kunst Anton E.
Published: January 2019

From 2014, the 28-day smoking abstinence campaign ‘Stoptober’ is held in the Netherlands. Each year, more than 50,000 people participate in what has become a nation-wide collective cessation attempt. This study aims to determine the short-term effects of ‘Stoptober’ on participants’ smoking behavior and behavioral determinants. Stoptober participants completed online surveys before the start of the campaign (n = 6856) and three months later (n = 1127). Descriptive statistics and t-tests were performed to determine changes in smoking and behavioral determinants. Logistic regression analyses were used to identify differences between subgroups. After three months, 71.8% of respondents had quit smoking and consumption was reduced among sustained smokers. Cessation rates were similar for subgroups by age, sex and educational level. Cessation was positively associated with confidence and self-efficacy at baseline and negatively associated with past year quit attempts and addiction level at baseline. For quitters, we found favorable changes in attitude towards cessation related stress, social norms, social pressure to smoke, self-efficacy to quit, smoking habit strength and smoker identity. For sustained smokers, we found favorable changes in attitude towards cessation related stress, self-efficacy and smoking habit strength. These results suggest that an abstinence campaign with a wide reach in a national population may be effective in decreasing smoking prevalence and cigarette consumption among a broad range of participants.
A Comparative Sociology of Gypsy Traveller Health in the UK
Authors: Millan Miranda , Smith David
Published: January 2019

This paper presents findings from a series of health-related studies undertaken between 2012 and 2017 with Romany Gypsies and Irish Travellers living in different locations and in various forms of accommodation in southern England. These set out to develop a sociological understanding of the factors impacting on the health and wellbeing of members of those communities and to consider the extent health status is shaped by ethno-cultural and/or socioeconomic factors, and the interplay and direction of causal processes between them. The relative influences of cultural and structural factors in generating health inequalities have important implications for engaging marginalised populations in health services and preventative programmes. This paper will present survey and qualitative data on Gypsies’ and Travellers’ health beliefs and practices to understand how those beliefs and practices have developed in different social contexts as responses to deeper social mechanisms, and share commonalities with other marginalised and excluded social groups. In policy terms this indicates the need for health interventions that are applied proportionate to the level of disadvantage experienced thus ensuring equality and fairness while accounting for diversity and difference.
A Group Decision Making Approach Considering Self-Confidence Behaviors and Its Application in Environmental Pollution Emergency Management
Authors: Liu Xia , Xu Yejun , Ge Yao , Zhang Weike , Herrera Francisco
Published: January 2019

Self-confidence as one of the human psychological behaviors has important influence on emergency management decision making, which has been ignored in existing methods. To fill this gap, we dedicate to design a group decision making approach considering self-confidence behaviors and apply it to the environmental pollution emergency management. In the proposed method, the self-confident fuzzy preference relations are utilized to express experts’ evaluations. This new type of preference relations allow experts to express multiple self-confidence levels when providing their evaluations, which can deal with the self-confidence of them well. To apply the proposed group decision making method to environmental pollution emergency management, a novel determination of the decision weights of experts is given combining the subjective and objective weights. The subjective weight can be directly assigned by organizer, while the objective weight is determined by the self-confidence degree of experts on their evaluations. Afterwards, by utilizing the weighted averaging operator, the individuals’ evaluations can be aggregated into a collective one. To do that, some operational laws for self-confident fuzzy preference relations are introduced. And then, a self-confidence score function is designed to get the best solution for environmental pollution emergency management. Finally, some analyses and discussions show that the proposed method is feasible and effective.
Health Assessment of Electronic Waste Workers in Chile: Participant Characterization
Authors: Yohannessen Karla , Pinto-Galleguillos Daniela , Parra-Giordano Denisse , Agost Amaranta , Valdés Macarena , Smith Lauren M. , Galen Katherine , Arain Aubrey , Rojas Felipe , Neitzel Richard L. , Ruiz-Rudolph Pablo
Published: January 2019

Little research has been done to evaluate the occupational health of electronic waste (e-waste) recycling workers in Latin America. The objective of this study was to complete comprehensive health evaluations on e-waste recycling workers in Chile and to compare those that work in informal (i.e., independent) to those that work in formal (i.e., established company) settings. A cross-sectional study in the summer of 2017 recruited 78 informal recycling workers from two cities and 15 formal e-waste recycling workers from a single recycling facility to assess exposures and health outcomes. Participants completed a health questionnaire and underwent a full health assessment. Herein, only health questionnaire data are reported. Participants were primarily male, middle-aged, married with children, and had worked in e-waste recycling for an average of 12 years. Participants generally reported good health status, and their prevalence of chronic diseases was comparable to national rates. Workers frequently reported exposures to several occupational stressors, including noise and insufficient income, as well as other mental health stressors. Occupational injuries were commonly reported and use of safety equipment was low. Only a few significant differences, generally of a rather small magnitude, were found between informal and formal workers. In conclusion, from survey data, we did not identify major risks to health among e-waste workers, and only minor differences between workers in informal and formal settings.
Stock Market Reactions to Brexit: Case of Selected CEE and SEE Stock Markets
Authors: Škrinjarić Tihana
Published: January 2019

The debate on the UK leaving the European Union is still hot and ongoing today due to many economic, political, social, and other consequences on many different countries over the world. This paper focuses on the reactions of selected Central and Eastern European (CEE) and South and Eastern European (SEE) stock markets to the Brexit vote on 23 June 2016. Using daily data for the time span from January 2010 until July 2016 and the event study methodology (ESM), the return and volatility series are being tested for significant reactions to the Brexit event. The results indicate mixed results regarding the abnormal cumulative return series, but the volatility series were found to be significantly affected by the mentioned event. This is important for international investors and gives information on the reaction of mentioned markets to big political and economic events in order to tailor international portfolios in a way to hedge from risk.
PARP-1/2 Inhibitor Olaparib Prevents or Partially Reverts EMT Induced by TGF-β in NMuMG Cells
Authors: Schacke Michelle , Kumar Janani , Colwell Nicholas , Hermanson Kole , Folle Gustavo A. , Nechaev Sergei , Dhasarathy Archana , Lafon-Hughes Laura
Published: January 2019

Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2). PARP-1 is nuclear and has also been detected in extracellular vesicles. PARP-2 and TNKS-1/2 are distributed in nuclei and cytoplasm. PARP or PAR alterations have been described in tumors, and in particular by influencing the Epithelial- Mesenchymal Transition (EMT), which influences cell migration and drug resistance in cancer cells. Pro-EMT and anti-EMT effects of PARP-1 have been reported while whether PAR changes occur specifically during EMT is currently unknown. The PARP-1/2 inhibitor Olaparib (OLA) is approved by FDA to treat certain patients harboring cancers with impaired homologous recombination. Here, we studied PAR changes and OLA effects on EMT. Total and nuclear PAR increased in EMT while PAR belts were disassembled. OLA prevented EMT, according to: (i) molecular markers evaluated by immuno-cytofluorescence/image quantification, Western blots, and RNA quantitation, (ii) morphological changes expressed as anisotropy, and (iii) migration capacity in the scratch assay. OLA also partially reversed EMT. OLA might work through unconventional mechanisms of action (different from synthetic lethality), even in non-BRCA (breast cancer 1 gene) mutated cancers.
Proteomic Analysis of Cyclic Ketamine Compounds Ability to Induce Neural Differentiation in Human Adult Mesenchymal Stem Cells
Authors: Santos Jerran , Milthorpe Bruce Kenneth , Padula Matthew Paul
Published: January 2019

Neural regeneration is of great interest due to its potential to treat traumatic brain injuries and diseases that impact quality of life. Growth factor mediated differentiation can take up to several weeks to months to produce the cell of interest whereas chemical stimulation may be as minimal as a few hours. The smaller time scale is of great clinical relevance. Adipose derived stem cells (ADSCs) were treated for up to 24 h with a novel differentiation media containing the cyclic ketamine compounds to direct neurogenic induction. The extent of differentiation was investigated by proteome changes occurring during the process. The treatments indicated the ADSCs responded favorably to the neurogenic induction media by presenting a number of morphological cues of neuronal phenotype previously seen and a higher cell population post induction compared to previous studies. Furthermore, approximately 3500 proteins were analyzed and identified by mass spectrometric iTRAQ analyses. The bioinformatics analyses revealed hundreds of proteins whose expression level changes were statistically significant and biologically relevant to neurogenesis and annotated as being involved in neurogenic development. Complementing this, the Bioplex cytokine assay profiles present evidence of decreased panel of stress response cytokines and a relative increase in those involved in neurogenesis.
Imerslund-Gräsbeck Syndrome in an Infant with a Novel Intronic Variant in the AMN Gene: A Case Report
Authors: Pacitto Alessandra , Prontera Paolo , Stangoni Gabriela , Stefanelli Maurizio , Ceppi Stefania , Cerri Carla , Gurdo Grazia , Mencarelli Annalisa , Esposito Susanna
Published: January 2019

Imerslund-Gräsbeck syndrome (IGS) is a rare autosomal recessive disorder clinically characterized by megaloblastic anemia, benign mild proteinuria, and other nonspecific symptoms. Several pathogenetic variants in the amnionless (AMN) or cubilin (CUBN) genes have been described in IGS. We describe a case of IGS with urinary tract infection and mild but persistent proteinuria at onset in an 11-month-old female child. With the appearance of macrocytic anemia, aphthous stomatitis, and neurological signs, IGS was clinically suspected, and vitamin B12 parenteral therapy was started. Sequence analysis showed the presence of a novel intronic variant c.513+5G>A of AMN, never before described in the literature, that was in compound heterozygosity with the known pathogenetic variant c.1006+34_1007-31del. Analysis extension to the parents revealed the presence of variant c.1006+34_1007-31 in the father and c.513+5G>A in the mother. In the present case with IGS, the novel intronic variant of AMN was identified in “trans” with a known pathogenic variant (c.1006-31 del) and the new variant was interpreted to be pathogenetic since it was not found in the public database of polymorphisms and because it was predicted to alter a donor splicing site. Our case underlines the relevance in detecting certain subtle symptoms, such as mild but persistent proteinuria associated with megaloblastic anemia, to reach a correct diagnosis of a rare but treatable disorder.
Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4
Authors: Huang Po-Kai , Lin Shian-Ren , Riyaphan Jirawat , Fu Yaw-Syan , Weng Ching-Feng
Published: January 2019

Serine protease dipeptidyl peptidase 4 (DPP-4) is involved in self/non-self-recognition and insulin sensitivity. DPP-4 inhibitors are conventional choices for diabetic treatment; however, side effects such as headache, bronchus infection, and nasopharyngitis might affect the daily lives of diabetic patients. Notably, natural compounds are believed to have a similar efficacy with lower adverse effects. This study aimed to validate the DPP-4 inhibitory activity of clerodane diterpene 16-hydroxycleroda-3,13-dien-15,16-olide (HCD) from Polyalthia longifolia, rutin, quercetin, and berberine, previously selected through molecular docking. The inhibitory potency of natural DPP-4 candidates was further determined by enzymatic, in vitro Caco-2, and ERK/PKA activation in myocyte and pancreatic cells. The hypoglycemic efficacy of the natural compounds was consecutively analyzed by single-dose and multiple-dose administration in diet-induced obese diabetic mice. All the natural-compounds could directly inhibit DPP-4 activity in enzymatic assay and Caco-2 inhibition assay, and HCD showed the highest inhibition of the compounds. HCD down-regulated LPS-induced ERK phosphorylation in myocyte but blocked GLP-1 induced PKA expression. For in vivo tests, HCD showed hypoglycemic efficacy only in single-dose administration. After 28-days administration, HCD exhibited hypolipidemic and hepatoprotective efficacy. These results revealed that HCD performed potential antidiabetic activity via inhibition of single-dose and long-term administrations, and could be a new prospective anti-diabetic drug candidate.
Development of a Dual-Vector System Utilizing MicroRNA Mimics of the Autographa californica miR-1 for an Inducible Knockdown in Insect Cells
Authors: Koczka Krisztina , Ernst Wolfgang , Palmberger Dieter , Klausberger Miriam , Nika Lisa , Grabherr Reingard
Published: January 2019

The baculovirus-insect cell expression system is a popular tool for the manufacturing of various attractive recombinant products. Over the years, several attempts have been made to engineer and further improve this production platform by targeting host or baculoviral genes by RNA interference. In this study, an inducible knockdown system was established in insect (Sf9) cells by combining an artificial microRNA precursor mimic of baculoviral origin and the bacteriophage T7 transcription machinery. Four structurally different artificial precursor constructs were created and tested in a screening assay. The most efficient artificial microRNA construct resulted in a 69% reduction in the fluorescence intensity of the target enhanced yellow fluorescent protein (eYFP). Next, recombinant baculoviruses were created carrying either the selected artificial precursor mimic under the transcriptional control of the T7 promoter or solely the T7 RNA polymerase under a baculoviral promoter. Upon co-infecting Sf9 cells with these two viruses, the fluorescence intensity of eYFP was suppressed by ~30–40% on the protein level. The reduction in the target mRNA level was demonstrated with real-time quantitative PCR. The presented inducible knockdown system may serve as an important and valuable tool for basic baculovirus-insect cell research and for the improvement of production processes using this platform.
Comparative Metabolic Profiling of Grape Skin Tissue along Grapevine Berry Developmental Stages Reveals Systematic Influences of Root Restriction on Skin Metabolome
Authors: Duan Shuyan , Wu Yusen , Fu Ruifeng , Wang Lei , Chen Yujin , Xu Wenping , Zhang Caixi , Ma Chao , Shi Jianxin , Wang Shiping
Published: January 2019

This research aimed to comparatively evaluate the influences of root restriction (RR) cultivation and traditional cultivation (RC) on grape berry skin metabolomics using a non-targeted metabolomics method. Two-hundred-and-ninety-one metabolites were annotated and the kinetics analyses showed that berry skin metabolome is stage- and cultivation-dependent. Our results showed that RR influences significantly the metabolomes of berry skin tissues, particularly on secondary metabolism, and that this effect is more obvious at pre-veraison stage, which was evidenced by the early and fast metabolic shift from primary to secondary metabolism. Altogether, this study provided an insight into metabolic adaptation of berry skin to RR stress and expanded general understanding of berry development.
T-Cell Accumulation in the Hypertensive Brain: A Role for Sphingosine-1-Phosphate-Mediated Chemotaxis
Authors: Don-Doncow Nicholas , Vanherle Lotte , Zhang Yun , Meissner Anja
Published: January 2019

Hypertension is considered the major modifiable risk factor for the development of cognitive impairment. Because increased blood pressure is often accompanied by an activation of the immune system, the concept of neuro-inflammation gained increasing attention in the field of hypertension-associated neurodegeneration. Particularly, hypertension-associated elevated circulating T-lymphocyte populations and target organ damage spurred the interest to understanding mechanisms leading to inflammation-associated brain damage during hypertension. The present study describes sphingosine-1-phosphate (S1P) as major contributor to T-cell chemotaxis to the brain during hypertension-associated neuro-inflammation and cognitive impairment. Using Western blotting, flow cytometry and mass spectrometry approaches, we show that hypertension stimulates a sphingosine kinase 1 (SphK1)-dependent increase of cerebral S1P concentrations in a mouse model of angiotensin II (AngII)-induced hypertension. The development of a distinct S1P gradient between circulating blood and brain tissue associates to elevated CD3+ T-cell numbers in the brain. Inhibition of S1P1-guided T-cell chemotaxis with the S1P receptor modulator FTY720 protects from augmentation of brain CD3 expression and the development of memory deficits in hypertensive WT mice. In conclusion, our data highlight a new approach to the understanding of hypertension-associated inflammation in degenerative processes of the brain during disease progression.
Global Transcriptional Insights of Pollen-Pistil Interactions Commencing Self-Incompatibility and Fertilization in Tea [Camellia sinensis (L.) O. Kuntze]
Authors: Seth Romit , Bhandawat Abhishek , Parmar Rajni , Singh Pradeep , Kumar Sanjay , Sharma Ram Kumar
Published: January 2019

This study explicates molecular insights commencing Self-Incompatibility (SI) and CC (cross-compatibility/fertilization) in self (SP) and cross (CP) pollinated pistils of tea. The fluorescence microscopy analysis revealed ceased/deviated pollen tubes in SP, while successful fertilization occurred in CP at 48 HAP. Global transcriptome sequencing of SP and CP pistils generated 109.7 million reads with overall 77.9% mapping rate to draft tea genome. Furthermore, concatenated de novo assembly resulted into 48,163 transcripts. Functional annotations and enrichment analysis (KEGG & GO) resulted into 3793 differentially expressed genes (DEGs). Among these, de novo and reference-based expression analysis identified 195 DEGs involved in pollen-pistil interaction. Interestingly, the presence of 182 genes [PT germination & elongation (67), S-locus (11), fertilization (43), disease resistance protein (30) and abscission (31)] in a major hub of the protein-protein interactome network suggests a complex signaling cascade commencing SI/CC. Furthermore, tissue-specific qRT-PCR analysis affirmed the localized expression of 42 DE putative key candidates in stigma-style and ovary, and suggested that LSI initiated in style and was sustained up to ovary with the active involvement of csRNS, SRKs & SKIPs during SP. Nonetheless, COBL10, RALF, FERONIA-rlk, LLG and MAPKs were possibly facilitating fertilization. The current study comprehensively unravels molecular insights of phase-specific pollen-pistil interaction during SI and fertilization, which can be utilized to enhance breeding efficiency and genetic improvement in tea.