bluuebunny/crossref_metadata_2025 huggingface dataset:
Glycemic Control and Metabolic Adaptation in Response to High-Fat versus High-Carbohydrate Diets—Data from a Randomized Cross-Over Study in Healthy Subjects
Authors: Wallenius Ville , Elebring Erik , Casselbrant Anna , Laurenius Anna , le Roux Carel W. , Docherty Neil G. , Biörserud Christina , Björnfot Niclas , Engström My , Marschall Hanns-Ulrich , Fändriks Lars
Published: September 2021

Granular study of metabolic responses to alterations in the ratio of dietary macro-nutrients can enhance our understanding of how dietary modifications influence patients with impaired glycemic control. In order to study the effect of diets enriched in fat or carbohydrates, fifteen healthy, normal-weight volunteers received, in a cross-over design, and in a randomized unblinded order, two weeks of an iso-caloric high-fat diet (HFD: 60E% from fat) and a high-carbohydrate diet (HCD: 60E% from carbohydrates). A mixed meal test (MMT) was performed at the end of each dietary period to examine glucose clearance kinetics and insulin and incretin hormone levels, as well as plasma metabolomic profiles. The MMT induced almost identical glycemia and insulinemia following the HFD or HCD. GLP-1 levels were higher after the HFD vs. HCD, whereas GIP did not differ. The HFD, compared to the HCD, increased the levels of several metabolomic markers of risk for the development of insulin resistance, e.g., branched-chain amino acid (valine and leucine), creatine and α-hydroxybutyric acid levels. In normal-weight, healthy volunteers, two weeks of the HFD vs. HCD showed similar profiles of meal-induced glycemia and insulinemia. Despite this, the HFD showed a metabolomic pattern implying a risk for a metabolic shift towards impaired insulin sensitivity in the long run.
Are Sensitivity to Punishment, Sensitivity to Reward and Effortful Control Transdiagnostic Mechanisms Underlying the Eating Disorder/Obesity Spectrum?
Authors: Claes Laurence , Kiekens Glenn , Boekaerts Els , Depestele Lies , Dierckx Eva , Gijbels Sylvia , Schoevaerts Katrien , Luyckx Koen
Published: September 2021

Although it has been postulated that eating disorders (EDs) and obesity form part of a broad spectrum of eating- and weight-related disorders, this has not yet been tested empirically. In the present study, we investigated interindividual differences in sensitivity to punishment, sensitivity to reward, and effortful control along the ED/obesity spectrum in women. We used data on 286 patients with eating disorders (44.6% AN-R, 24.12% AN-BP, and 31.82% BN), 126 healthy controls, and 640 Class II/III obese bariatric patients (32.81% Class II and 67.19% Class III) with and without binge eating. Participants completed the behavioral inhibition and behavioral activation scales, as well as the effortful control scale, to assess sensitivity to punishment and reward and effortful control. Results showed that patients with EDs scored significantly higher on punishment sensitivity (anxiety) compared to healthy controls and Class II/III obese patients; the different groups did not differ significantly on reward sensitivity. Patients with binge eating or compensatory behaviors scored significantly lower on effortful control than patients without binge eating. Differences in temperamental profiles along the ED/obesity spectrum appear continuous and gradual rather than categorical. This implies that it may be meaningful to include emotion regulation and impulse regulation training in the treatment of both EDs and obesity.
Pathway Preferential Estrogens Prevent Hepatosteatosis Due to Ovariectomy and High-Fat Diets
Authors: Zuo Qianying , Chen Karen L. , Arredondo Eve Alicia , Liu Yu-Jeh , Kim Sung Hoon , Katzenellenbogen Benita S. , Katzenellenbogen John A. , Madak-Erdogan Zeynep
Published: September 2021

About 20–30% of premenopausal women have metabolic syndrome, and the number is almost double in postmenopausal women, and these women have an increased risk of hepatosteatosis. Postmenopausal women with metabolic syndrome are often treated with hormone replacement therapy (HRT), but estrogens in currently available HRTs increase the risk of breast and endometrial cancers and Cardiovascular Disease. Therefore, there is a critical need to find safer alternatives to HRT to improve postmenopausal metabolic health. Pathway preferential estrogen 1 (PaPE-1) is a novel estrogen receptor ligand that has been shown to favorably affect metabolic tissues without adverse effects on reproductive tissues. In this study, we have examined the effects of PaPE-1 on metabolic health, in particular, examining its effects on the liver transcriptome and on plasma metabolites in two different mouse models: diet-induced obesity (DIO) and leptin-deficient (ob/ob) mice. PaPE-1 significantly decreased liver weight and lipid accumulation in both DIO and ob/ob models and lowered the expression of genes associated with fatty acid metabolism and collagen deposition. In addition, PaPE-1 significantly increased the expression of mitochondrial genes, particularly ones associated with the electron transport chain, suggesting an increase in energy expenditure. Integrated pathway analysis using transcriptomics and metabolomics data showed that PaPE-1 treatment lowered inflammation, collagen deposition, and pathways regulating fatty acid metabolism and increased metabolites associated with glutathione metabolism. Overall, our findings support a beneficial metabolic role for PaPE-1 and suggest that PaPE-1 may protect postmenopausal women from fatty liver disease without increasing reproductive cancer risk.
An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders
Authors: Vandenplas Yvan , Gerlier Laetitia , Caekelbergh Karin ,   Nan-Study-Group, Possner Mike
Published: September 2021

Functional gastro-intestinal disorders (FGIDs) impair the quality of life of many infants and their families. A formula with partial whey hydrolysate, starch, high magnesium content, prebiotic fructo-oligosaccharide and galacto-oligosaccharide and the probiotic Lactobacillus reuteri DSM 17938 was given during two weeks to 196 infants with at least two FGIDs. The efficacy was evaluated with the Cow Milk-associated Symptom Score (CoMiSS®) and quality of life with the QUALIN score. The formula was shown to decrease FGIDs within three days (decrease of CoMiSS −1.29 (3.15) (mean (SD), p < 0.0001) followed by an improvement of quality of life after seven days (increase QUALIN +1.4 (7.8); p: 0.008). Constipation decreased from 18.8% to 6.5% within three days. In combination with reassurance and guidance, the nutritional intervention was shown to be effective in infants with FGIDS in real-life circumstances.
Peptide Nanoparticle-Mediated Combinatorial Delivery of Cancer-Related siRNAs for Synergistic Anti-Proliferative Activity in Triple Negative Breast Cancer Cells
Authors: Egorova Anna , Pyankov Ivan , Maretina Marianna , Baranov Vladislav , Kiselev Anton
Published: September 2021

Triple negative breast cancer (TNBC) is one of the deadliest types of cancer for women of different age groups. Frequently this cancer does not respond to conservative treatment. Combinatorial RNAi can be suggested as an advanced approach to TNBC therapy. Due to the fact that TNBC cells overexpress chemokine receptor 4 we used modular L1 peptide-based nanoparticles modified with CXCR4 ligand for combinatorial delivery of siRNAs suppressing major transduction pathways. TNBC cell line MDA-MB-231 was used as a cellular model. Genes encoding the AQP3, CDC20, and COL4A2 proteins responsible for proliferative activity in TNBC cells were selected as RNAi targets. The siRNA binding ability of the carrier was studied at different charge ratios. The silencing specificity was demonstrated for all siRNAs studied. Alamar Blue proliferation assay has shown significant reduction in the anti-proliferative activity after combinatorial siRNA transfection compared to single siRNA delivery. The most significant synergistic effect has been demonstrated for combinatorial transfection of anti-COL4A2 and anti-CDC20 siRNAs what resulted in 1.5–2 fold inhibition of proliferation and migration of TNBC cells. Based on our findings, we have concluded that combinatorial treatment by CXCR4-ligand modified L1-polyplexes formed with AQP3, CDC20, and COL4A2 siRNAs effectively inhibits proliferation of TNBC cells and can be suggested as useful tool for RNAi-mediated cancer therapy.
Forms and Methods for Interferon’s Encapsulation
Authors: Ramos Thelvia I. , Villacis-Aguirre Carlos A. , Santiago Vispo Nelson , Santiago Padilla Leandro , Pedroso Santana Seidy , Parra Natalie C. , Alonso Jorge Roberto Toledo
Published: September 2021

Interferons (IFNs) are cytokines involved in the immune response that act on innate and adaptive immunity. These proteins are natural cell-signaling glycoproteins expressed in response to viral infections, tumors, and biological inducers and constitute the first line of defense of vertebrates against infectious agents. They have been marketed for more than 30 years with considerable impact on the global therapeutic protein market thanks to their diversity in terms of biological activities. They have been used as single agents or with combination treatment regimens, demonstrating promising clinical results, resulting in 22 different formulations approved by regulatory agencies. The 163 clinical trials with currently active IFNs reinforce their importance as therapeutics for human health. However, their application has presented difficulties due to the molecules’ size, sensitivity to degradation, and rapid elimination from the bloodstream. For some years now, work has been underway to obtain new drug delivery systems to provide adequate therapeutic concentrations for these cytokines, decrease their toxicity and prolong their half-life in the circulation. Although different research groups have presented various formulations that encapsulate IFNs, to date, there is no formulation approved for use in humans. The current review exhibits an updated summary of all encapsulation forms presented in the scientific literature for IFN-α, IFN-ß, and IFN-γ, from the year 1996 to the year 2021, considering parameters such as: encapsulating matrix, route of administration, target, advantages, and disadvantages of each formulation.
Does the Vehicle Matter? Real-World Evidence on Adherence to Topical Treatment in Psoriasis
Authors: Teixeira Ana , Teixeira Maribel , Almeida Vera , Gaio Rita , Torres Tiago , Magina Sofia , Cunha Cátia , Sousa Lobo José M. , Almeida Isabel F.
Published: September 2021

The influence of the vehicle in topical treatment adherence remains to be elucidated. The aim of this study is to analyze the influence of the pharmaceutical dosage form on adherence to topical treatment in psoriasis patients, taking into consideration the mechanical features. The adherence was evaluated in a sample of 102 psoriasis patients, followed for approximately 45 days. Adherence was calculated with a new combined methodology using a log and medication weights. The effect of the group formulation was evaluated using logistic regression models. A complex effect of the vehicle on adherence was found, mediated by the affected area. The adherence was significantly higher for patients applying gels and creams than for those using ointments, whenever the body area affected was extensive. The opposite was found when the affected area was small. Mechanical properties can partially explain the findings since gels and creams may be easier to apply. Patient beliefs and preferences regarding vehicles and their sensory attributes might also explain the results. It is noteworthy that adherence was strikingly low, with more than 75% non-adherent patients. This real-world evidence provides an insight for pharmaceutical industries and guidance for treatment prescription by physicians aiming to address the public health emergency of treatment non-adherence.
Zinc-Phthalocyanine-Loaded Extracellular Vesicles Increase Efficacy and Selectivity of Photodynamic Therapy in Co-Culture and Preclinical Models of Colon Cancer
Authors: Lara Pablo , Huis in ‘t Veld Ruben V. , Jorquera-Cordero Carla , Chan Alan B. , Ossendorp Ferry , Cruz Luis J.
Published: September 2021

Photodynamic therapy (PDT) is a promising and clinically approved method for the treatment of cancer. However, the efficacy of PDT is often limited by the poor selectivity and distribution of the photosensitizers (PS) toward the malignant tumors, resulting in prolonged periods of skin photosensitivity. In this work, we present a simple and straightforward strategy to increase the tumor distribution, selectivity, and efficacy of lipophilic PS zinc phthalocyanine (ZnPc) in colon cancer by their stabilization in purified, naturally secreted extracellular vesicles (EVs). The PS ZnPc was incorporated in EVs (EV-ZnPc) by a direct incubation strategy that did not affect size distribution or surface charge. By using co-culture models simulating a tumor microenvironment, we determined the preferential uptake of EV-ZnPc toward colon cancer cells when compared with macrophages and dendritic cells. We observed that PDT promoted total tumor cell death in normal and immune cells, but showed selectivity against cancer cells in co-culture models. In vivo assays showed that after a single intravenous or intratumoral injection, EV-ZnPc were able to target the tumor cells and strongly reduce tumor growth over 15 days. These data expose opportunities to enhance the potential and efficacy of PDT using simple non-synthetic strategies that might facilitate translation into clinical practice.
A New Perspective for Solving Manufacturing Scheduling Based Problems Respecting New Data Considerations
Authors: Awad Mohammed A. , Abd-Elaziz Hend M.
Published: September 2021

In order to attain high manufacturing productivity, industry 4.0 merges all the available system and environment data that can empower the enabled-intelligent techniques. The use of data provokes the manufacturing self-awareness, reconfiguring the traditional manufacturing challenges. The current piece of research renders attention to new consideration in the Job Shop Scheduling (JSSP) based problems as a case study. In that field, a great number of previous research papers provided optimization solutions for JSSP, relying on heuristics based algorithms. The current study investigates the main elements of such algorithms to provide a concise anatomy and a review on the previous research papers. Going through the study, a new optimization scope is introduced relying on additional available data of a machine, by which the Flexible Job-Shop Scheduling Problem (FJSP) is converted to a dynamic machine state assignation problem. Deploying two-stages, the study utilizes a combination of discrete Particle Swarm Optimization (PSO) and a selection based algorithm followed by a modified local search algorithm to attain an optimized case solution. The selection based algorithm is imported to beat the ever-growing randomness combined with the increasing number of data-types.
Race, Racism, and the Hebrew Bible: The Case of the Queen of Sheba
Authors: Stinchcomb Jillian
Published: September 2021

The Queen of Sheba, best known for visiting Solomon at the height of his rule, is commonly understood to be one of the most famous Black queens of the Bible. However, biblical texts record nothing of her family or people, any physical characteristics, nor where, precisely, Sheba is located. How did this association between the Queen of Sheba and Blackness become naturalized? This article answers this question by mapping three first millennium textual moments that racialize the Queen of Sheba through attention to geography, skin color, and lineage in the writings of Origen of Alexandria, Flavius Josephus, and Abu Ja’afar al-Tabari. These themes are transformed in the Ethiopic text the Kebra Nagast, which positively claims the Queen of Sheba as an African monarch in contrast to the Othering that is prominent in earlier texts. The Kebra Nagast has a complex afterlife, one which acts as the ground for the also-complex modern reception of the character of the Queen of Sheba.
BERNARDO PAREJA COMO LECTOR: CRÍTICA Y POÉTICA EN ARGONAUTAS DEL ESPÍRITU
Authors: Castrillón Carlos , Rojas Vivian , Echeverri Laura
Published: September 2021

En este artículo se analizan en sus fundamentos teóricos y metodológicos los ensayos de crítica literaria del poeta colombiano Bernardo Pareja, Argonautas del Espíritu, en el contexto de la historia de la crítica literaria en el Quindío. El objetivo es definir la importancia del autor como ensayista en la tradición de la literatura del Gran Caldas. Para el efecto se propone una edición anotada con estudio previo de un conjunto representativo de los ensayos inéditos, con lo cual se demuestra la vigencia de la crítica impresionista en el contexto local.
GENESIS OF THE CONCEPT “MUSICAL CULTURE OF THE PERSONALITY” IN THE CONTEXT OF GENERAL MUSIC EDUCATION
Authors: Lobova Olga
Published: September 2021

Article is devoted to research of genesis of the concept “musical culture of the personality”. On the basis of the analysis of philosophical, cultural і pedagogical works done, we observed the attitude towards this phenomenon in the context of the general music education.The musical culture of the school student is considered as individual  and unique, complex integrative education. Formation of musical culture of pupils is observed as the leading reference point of school music education which is a necessary component of versatile development and harmonious education of the child.
ORGANIC UNITY OF MAN AND NATURE AS POLYSYSTEMIC ESSENCE OF MODERN DESIGN TRENDS
Authors: Silko Eugene
Published: September 2021

The article analyzes the crisis in the development of modern Ukrainian society with its characteristics such as the magnitude and consistency; special emphasis is placed on such negative signs of the younger generation outlook of Ukrainians as a lack of spirituality and excessive materialization. Certain changes to overcome these deep problems are possible, by providing the view of a man through the prism of polysystemic knowledge which considers man as a member living in many worlds at the same time - the world of the family, the world of the ethnic group, class world, the world of nature and society.In the context of polysystemic knowledge, design acquires a special sounding such as philosophical, activity and creative and educational system. The prospects and the effectiveness of this system is determined by a wide palette of tools (by creatively converting to educational), aimed to spiritual formation and harmonious development of personality.Environmental design is one of the latest paradigm of modern vision of planetary reality, when the environment gets their properties already in the artistic and technical creativity. Ecological design is a general indication of the vision ofmodern man as a social and, above all, biological being, which seeks to live in harmony with the nature.The article provides the definition and reveals semantic content of the definition of “The idea of man and nature unity” in the context of a systematic approach; analyzes the modern design trends from the perspective of polysystemic fact of the idea of man and nature unity. The historical development of mankind, with the exception of its modern realities, has always been characterized by the organic unity of man and nature: a close relationship with the mentality of the country, with natural  and climatic conditions of the respective areas formed the human world from the earliest historical eras. The article explains the dual nature of modern design depending on environmental and national components. The environmental movement, that is gaining a great momentum in design and culture, dues to two trends. The first - the ecology of culture - is trying to “raise” etnonature and is connected with the revival of national identity. Another trend - the ecology of nature - is associated with overcoming of disastrous imbalance in the natural environment. These two defining trends are in close intercommunication – cultural environment is impossible without natural basis and ecology of nature is impossible without cultural man.
TEACHING AND EDUCATING STRATEGIES IN UKRAINIAN SCHOOLING ABROAD
Authors: Ponomarevskyi Stanislav
Published: September 2021

Organization and content specificities as well as the basic principles of some teaching and educative strategies useful for Ukrainian schooling activity overseas (Sunday and Saturday Ukrainian schools, schools providing Ukrainian study courses, bilingual schools, etc.) that is functioning in the countries with Ukrainian ethnical component are analyzed in the article. On the base of sources and special literature studying, it was clarified that implementing aspects of pedagogical strategies in the domain of Ukrainian studies are out of scientific interest of the national and foreign researchers. Thus, the objective of this article is to outline the range of basic strategies which could become practical for coordination of the youth teaching and educating in Ukrainian schools abroad.Nowadays life requires of teachers to improve and understand their competent responsibility, as a teacher should be a person able to actively affect the progress of those, who are taught and educated. Educational paradigm of the XXI century must rely on the dominant when the talented individual’s activity as a teacher and creator is to move beyond the course and become the medium as well as transmitter of the world and national values. Pedagogical activity due to these terms will logically result in teacher’s awareness, directed to the balanced achievements of their students, the ability to use their skills formed, to understand the national originality, especially being surrounded by different ethnical and cultural conditions of another country.In any country, where Ukrainian studies are promoted, the implementation of teaching and educating strategies in educational affiliations has its own peculiarities. There is the necessity to widely use Ukrainian study components during teaching and educating process, because they are important for national self-identification formation of the students. This is the basic purpose of Ukrainian institutions’ activity abroad. For this reason, a teacher should accurately choose efficient as well as aim- appropriate teaching and educating strategies out of those, which are ‘programmed’ to realize the purpose mentioned above.Therefore, the basic opportunities of realization, teaching and educating requirements and goals due to multilingual and multicultural availability were outlined in the article. Specific examples of practical strategies implementing in national schools abroad were given. In particular, the attention was drawn to potential of using strategies integrated with individually oriented, programmed, differentiated teaching as well as scouts education strategies and some other.The peculiarities of curricula usage in pedagogical practice regarding to Ukrainian schooling abroad were also reviewed.
READING AND LITERARY EDUCATION IN IST-IIIRD CLASSES OF PRIMARY SCHOOL AS A SOURCE OF MULTI-ACTIVITY OF STUDENTS
Authors: Yanitska-Panek Teresa
Published: September 2021

Literary education is very important in the process of forming the personality of the individual. It is necessary to implement a number of conditions in order to student’s contact with literature was a great experience. Reading can be seen as a way of man’s existence in the world of symbols and information. Reading can also be a medium through which cultural content reaches to the recipient and enrich and improve his language and engage him emotionally. Reading is an act of great importance, austerity and effort, and at the same time it is an act of preparing the reader and the recipient to the reflection.Many authors emphasize the value of reading, inspired many motives. The authors draw attention to the different attitudes towards reading of the text which have been described by Lech Witkowski, philosopher and pedagogue in 2007. Eight status of the text in the course of reading are specific hints for teachers and non-pedagogical readers how to treat the text. The philosopher’s look on the function of reading puts this ability in a variety of contexts and makes that people interested in reading can become seekers and creative.The reading is determined the following learning outcomes: student reads fluently, correctly, fluently and expressively aloud texts consisting of words discussed during classes. These texts relate to real-life experiences of children and cognitive expectations. A student also understands short texts read silently; student correctly reads aloud texts written own in a notebook and texts stored on a PC. The student working with text by searching for the most beautiful piece. He is also able to distinguish in literary texts the forms such as narrative, description and dialogue.
EDUCATION FEELING FAMILY-CULTURAL IDENTITY BY METHODS OF DESCRIPTIVE ART
Authors: Mokhireva Julia
Published: September 2021

In research autors propounds determination one of topical problems of modern art education – forming a true artist-citizen with feeling of family-cultural identity, which are possible on basis of national spirituality owing to assimilation principles and forms of national culture.The garanty of success are: appeal to future teachers of descriptive art to ethnic traditions, searching for the new innovative forms of expression, high professional level degree. Now is disclosed pedagogical-cultural potential of learning art of modern Ukrainian artists, and, in particular, of art dynasty of Poltava.In  the  chail  of  art  Poltava’s  national  pedagogical  university  named  be V. Korolenko  theoretical  knowledge  about  history  of  Ukrainian  art,  it’s  modern condition, supported by deep personal informative processes.Great attention is givet to mastery of students practical skills. Conceptualizing source of Ukrainian art like the most important spiritual factor; students are teaching an art techiques of expression: they are developing compositions degree of difficulty; using computer techologies; young artists are joining to art exhibition.
DEVELOPMENT OF PEDAGOGICAL SKILLS OF SPECIAL SUBJECTS’ TEACHERS WHILE ADVANCED TRAINING
Authors: Rudenko Larisa , Overko Natalia
Published: September 2021

The article highlights the basic theoretical principles of the author's technique of pedagogical skills development of special subjects’ teachers at vocational schools in the process of advanced training. A prerequisite for its development is the fact that the majority of special subjects’ teachers at vocational schools in various fields have professional experience in various industries and the service sector; however, they do not have pedagogical education. The quality update of training in the vocational education system requires that teachers have basic professional knowledge as well as pedagogical one, creative approach to the development of specific educational problems, implementation of innovative techniques into the training process. Taking it into consideration, the development of pedagogical skills of special subjects’ teachers can be achieved in the process of advanced training.For that purpose, the technique of pedagogical skills development of special subjects’ teachers, which offers to carry out this process step by step, was designed and implemented on the advanced training courses for teachers of vocational education system. Each stage of the technique is consistent with one of the pedagogical conditions that insure the achievement of a certain level of pedagogical skills formation. The gradual build-up of components provides a consistent and systematic process, and promotes teachers’ awareness of the need for constant professional and personal self-development, development of pedagogical techniques, and formation of readiness for creative educational activities in accordance with modern requirements for the training of qualified specialists in different fields.
PSYCHOSOCIAL FUNCTIONING OF PRE-ADOLESCENT CHILDREN IN FAMILIES WITH DIFFERENT ATTITUDES TOWARDS SCHOOLING
Authors: Berezina K. , Kotenko S. , Malysheva A.
Published: September 2021

The article is devoted to the analysis of differences in the psychosocial functioning of adolescents in families with different attitudes to school responsibilities. Modern school education provides a lot of space for creativity, the choice of methods of mastering the program, which, at the same time, is becoming more demanding. It can be difficult for parents to determine the extent to which they give their children homework responsibility. This is especially true for adolescents (9-12 years old), who no longer seem to need help and control in the school process. At the same time, complete lack of control can cause alarm on the part of all participants in this complex process.

An experimental study found that adolescents whose parents do not consider it appropriate to interfere in the school process, show a low level of psychosocial development. This result may mean that these children lack the ability to perform daily activities and enter into relationships with people in a way that satisfies both parties. Most middle school students with low levels of psychosocial functioning usually have internalization problems. That is, it is difficult for them to show themselves and be socially active. Whereas externalized (external) symptoms of psychosocial development disorders are not expressed in both groups.

An additional study of the level of anxiety revealed differences between the groups on the scales "separation anxiety", "social phobia" and "school phobia". In families where parents have dropped out of school for their children, starting in middle school, the level of anxiety on these scales is higher. On the scales "somatic symptoms of anxiety", "generalized anxiety disorder" there are no significant differences between the samples - in both groups, the indicators on these scales do not exceed an acceptable level. Thus, it can be assumed that the complete non-interference of parents in the school process of children in middle school can be perceived by them as a lack of parental attention, which affects the confidence in support in school activities, which, nevertheless, occupies a large place in children's daily lives. school age.
THE PECULIARITIES OF PROFESSIONAL SELF-ACTUALIZATION OF STUDENTS-PSYCHOLOGISTS WHO EXPERIENCING THE CRISIS OF PROFESSIONAL READINESS
Authors: Hutyrya M. , Kononova M.
Published: September 2021

The article is devoted to the problem of features of professional self-actualization of students-psychologists living in crisis of professional readiness. The definition of the term self-actualization and professional self-actualization among the works of domestic, Russian and foreign scientists is considered. In particular, professional self-actualization is defined as a complex multilevel phenomenon, a process of directed activity aimed at progress in one's own professional development, which is conditioned by the disclosure of one's own professional potential. Three approaches to the study of self-actualization in the professional sphere are highlighted: subject-activity, where professional activity is the main basis for self-actualization of the individual, due to difficulties and internal contradictions; personal development, where professional self-actualization leads to profound internal changes and forms and professional maturity; acmeological, in which professional self-actualization is the achievement of the highest level of professionalism, professional and personal maturity ("acme"). The concept of crisis of professional readiness and features of living of crisis by psychology students are analyzed. It is noted that the level of experiences of the crisis of professional readiness is the most intense among other normative crises of professional training. The peculiarities of the crisis development are highlighted: the contradiction between the awareness of the beginning of professional activity and at the same time the lack of readiness. The intra-personal conflict between learning motivations and professional motivation is determined. A number of features of professional self-actualization of students-psychologists and their interrelation with the crisis of professional readiness are considered.
CLINICAL AND FUNCTIONAL DISORDERS OF CARDIORESPIRATORY SYSTEM IN PATIENTS WITH COVID-19
Authors: Smirnova A.Yu. , Gnoevykh V.V. , Shorokhova Yu.A. , Chernova N.G. , Serov V.A. , Razin V.A.
Published: September 2021

The goal of the paper is to range information about early and delayed clinical and functional disorders of the respiratory and cardiovascular systems after COVID-19. The review focuses on clinical and functional diagnostic methods (laboratory, instrumental and radiation) of disorders of the cardiovascular and respiratory systems in patients after COVID-19.
At the moment, enough data has been accumulated confirming early and aftereffect of COVID-19. The need for further rehabilitation may be caused by the presence and severity of clinical and functional disorders of the respiratory and cardiovascular systems.
Key words: coronavirus disease (COVID-19), impaired respiratory function and diffusion lung capacity, acute myocardial injury, electrical myocardium instability.
Цель – систематизировать сведения о ранних и отсроченных клинико-функциональных нарушениях дыхательной и сердечно-сосудистой систем после перенесенной коронавирусной инфекции.
В обзоре основное внимание уделено клинико-функциональным методам диагностики (лабораторным, инструментальным и лучевым) нарушений сердечно-сосудистой и дыхательной систем у пациентов, перенесших COVID-19.
На данный момент накоплено достаточно данных, подтверждающих наличие ранних и отсроченных последствий новой коронавирусной инфекции. Необходимость дальнейшей реабилитации может быть обусловлена наличием и тяжестью клинико-функциональных нарушений со стороны органов дыхания и сердечно-сосудистой системы.
Ключевые слова: новая коронавирусная инфекция (COVID-19), нарушения функции внешнего дыхания и диффузионной способности легких, острое повреждение миокарда, электрическая нестабильность миокарда.
А. Чехов та І. Карпенко-Карий: реформа драматургії та сценічної практики. Основні аспекти
Authors: Шестакова Дар’я Вікторівна
Published: September 2021

У цій праці пропонується поглянути на постаті А.Чехова та І. Карпенка-Карого як на драматургів-реформаторів. Авторка зважає на соціокультурний контекст, в якому формувався і працював кожен з них. У дослідженні відбувається порівняльний аналіз драматургічної спадщини А. Чехова та І. Карпенка-Карого і визначаються основні аспекти реформи .У результаті аналізу очевидним стає новаторський потенціал їхніх драматичних творів. Він розмикає базові для кожного з них естетичні системи і розкривається у нових тенденціях театрального мислення.
Метамодернізм: теоретична реальність чи «Фігура Філософії»?
Authors: Оніщенко Олена Ігорівна
Published: September 2021

У статті розглянуто феномен «метамодернізму», що його окремі європейські культурологи оцінюють як черговий етап у русі «модернізм — постмодернізм — пост + постмодернізм — метамодернізм». Окреслено напрями впливу «метамодернізму» на сучасне мистецтво, представники якого використовують «нову естетичну чуттєвість» — quirky. Водночас, слід враховувати, що широке коло питань, пов’язаних з теоретичним осмисленням означених трьох етапів, які передують «метамодернізму» до сьогодні перебувають у дослідницькому просторі, оскільки їх інтерпретація зберігає «білі плями».
Ліричний модус жанрової семантики в концепції «слабкого стилю» В. Сильвестрова
Authors: Овсяннікова-Трель Олександра Андріївна
Published: September 2021

Мета статті полягає у визначенні функціональних значень жанрово-семантичного рівня поетики інструментальних творів В. Сильвестрова, що репрезентує індивідуально-стильову специфіку композиторської концепції «слабкого стилю». Жанрово-інтонаційні метафори романсової лірики, якими користується композитор, розглядаються в комунікативному аспекті, що дає змогу визначати їх як основні чинники формування музичного смислу за допомогою спогаду про жанрово-семантичний образ романсу
Development of Instructional Materials centered on standardization hands-on activities of wind generator blades for middle and high school levels in accord with performance criteria of Standard problem solving
Authors:   Korean Technology Education Association, Joo Inkyu
Published: September 2021

The purpose of this study is to develop standardized hands-on Instructional materials(middle and high school standardized hands-on activities center Instructional materials) that activities for middle and high school level which focuses on wind generator blades in according with performance criteria on standard problem solving. For this, the three stages of preparation, development, and improvement were developed as follows, focusing on standardized hands-on activities for middle and high school.

In the preparation phase, I analyzed the criteria of standard problem solving achievement in the 2015 revised curriculum of ‘Technology-Home Economics’subject. Also in this phase, I analyzed the standardization of hands-on activity task presented in a total of 12 kinds of middle and high school textbooks. Also, the task selection and educational goals were extracted through it.

In the development phase, 2015 revised curriculum of‘Technology-Home Economics’subject the middle school Instructional material was presented as `making standard blades for wind power generation by utilizing `Use of technology and standards . Just like this, the high school Instructional material was presented as `making standard blades for wind power generation by utilizing `Technology Development and Standards .
Constant Resistance During Proportional Speed Provoked Higher Lower Limb Proximal Musculature Recruitment than Distal Musculature in Young Healthy Adults
Authors: G. Rosario Martin , Keitel Kelly , Meyer Josey
Published: September 2021

The lack of exercise in society today often leads to severe muscle loss and poor physical performance. Training methods targeting specific weakened muscle groups can help prevent or counteract muscle loss. This study aimed to analyze how the lower extremity muscles are activated when pushing a sled with constant resistance at two different speeds. Twenty-six participants with an average age of 23.77 years consented to having electromyography surface electrodes placed along the gluteus maximus (GMax), gluteus medius (GMed), tibialis anterior (TA), and gastrocnemius (GA) of their dominant leg. Muscle activation levels were then measured while the participant walked and ran with and without sled resistance. The study results showed that muscle activation was comparable during all trials and was not influenced by speed or constant resistance. However, the muscle activation for GMax and GMed was significantly higher than the activation levels exhibited by GA and TA. While pushing a sled has been shown to impact all studied musculature similarly, adding resistance to the movement can affect gait parameters such as stride length and cadence. Our findings support the use of sled training in patients with hip pathologies who are seeking to strengthen their GMax and GMed.
The Viability of Cross-Country Running Appearing in the Winter Olympic Games
Authors: Hutchinson Andrew Boyd
Published: September 2021

Today, cross-country running celebrates over 200 years of being a practiced, organized sport. Originally adapted as a form of imitation fox hunting by schoolboys in England, it is now a globally sanctioned program governed by World Athletics, which oversees marathon running, track and field, and other athletics events. First introduced to the International Olympic Committee by Percy Fischer, a member of the Olympic track committee of the Amateur Athletics Association in October 1910, cross-country running appeared three times on the program for the Summer Olympic Games in 1912, 1920, and 1924 as both a team and individually-scored event. Due to the overwhelming popularity of track and field and marathon events in the current Olympic Games program in the summer, recent attention has turned to promoting cross-country running––largely practiced in the autumnal and winter months the world over––for inclusion on the Winter Olympic Games schedule.
Despite a history of nearly 100 years of efforts for reinclusion back into the Olympics, cross-country running has had difficulty in gaining traction for support for the winter program, largely due to the winter olympic charter mandating all sports be practiced exclusively on snow or ice.
Perception of the Vulnerability and the Resilience Status of Local Economic Enterprises: The Case Study of the Sao Joao Do Lago Do Tupe Community
Authors: A. F. Norte Filho, , D. F. Mariosa , O. M. Falsarella , T. J. P. Fraxe , N.N.B. Norte
Published: September 2021

The traditional inhabitants of the Amazon settled on the banks of the several rivers and streams that cut through the forest, and from there they take their daily livelihood through hunting, fishing and handicrafts made from the materials found around them. The actions of protection, preservation, care and conservation are imperative to guarantee the survival of the place. Especially when disruptive events affect the local balance, such as the effects of climate change or the economic and health crises, such as the COVID pandemic19. By restricting the movement of people to avoid contagion and the spread of the disease, it also restricted the spectrum of daily activities for a good portion of the population, which caused disruption in the system. Based on semi-open interview techniques and direct observation of economic entrepreneurs, the São João do Lago do Tupé riverside community, located in the Tupé Development Reserve, Manaus, Amazonas, the study aims to analyze the perception of the vulnerability of these enterprises in the market, finance, organization and cooperation dimensions and assess the state of resilience in the face of the adverse conditions that may reach them.
Acrometastasis: A Rare Entity. A Proximal Radius Case
Authors: Esperanza Holgado-Moreno , Eduardo Cabezuelo-Díaz-Miguel , Félix Sánchez-Sánchez , Leticia Alarma-Barcia , Sandra Guijarro-Leo
Published: September 2021

Bone metastases under de knee and elbow (acrometastasis) are rare. We present the case of a patient diagnosed with lung adenocarcinoma, with a lesion in the right proximal radius. Radiological imaging through CT and MR suggested metastatic lesion, which anatomopathological results confirmed. As the presence of these markers provides a poor outlook, radiotherapy was initially considered. However, given the clinical stability of the patient and the limited amelioration observed, surgical treatment was finally conducted.
Contribution of Agriculture Sector in Economic Growth of Pakistan: An Empirical Analysis
Authors: Zaman Sumia Bint , Ishaq Muhammad , Niazi Muhammad Azam
Published: September 2021

There has been controversy in the field of development economics about the significance of the role of agriculture sector in economic growth. Going through the data, it indicates that agriculture sector is significant contributor to the economy of Pakistan as it contributes about 19% in national GDP. This study was designed to statistically test the contribution of agriculture sector in economic growth of Pakistan through estimation of relationship between agriculture sector and Pakistan’s economic growth using Autoregressive Distributed Lag (ARDL) bounds test and Error Correction Model (ECM). Time series data on selected variables was utilized from 1961-2018. Study found that real agricultural value added has a significant positive impact on real GDP per capita in the long-run where one percent increase in real agricultural value added increases the real GDP/capita by 0.35%. This indicated that the promotion of agriculture sector leaves far reaching effects with respect to economic growth of the country. These results advocated for the development of agriculture sector in line with the long-term goals of economic growth and emphasized in investing in agriculture sector. Coefficient of error correction term (ECT) is -0.62 meaning that if there is any disequilibrium, it will restore @ 62 percent in the first period. Results also proved the importance of capital formation both the physical capital and human capital. Finding suggested that we should investment in human health to enhance the economic growth as suggested by exogenous growth theory. Moreover, it can also be suggested to create conducive environment and economic opportunities to reap the benefits of demographic dividends of decreased mortality in the long-run. As per analysis, maintaining stability is critically important for economic growth. Moreover, literature hypothesize the positive effect of TOT for economic growth, but analysis indicated that TOT has not been able to put any significant impact on economic growth. Further, trend analysis also pointed out that TOT has been fluctuating over the time. It can be inferred from the analysis that there is need to stabilize TOT and restructure the exports of the country to generate the significant positive impact.
OVARIOHISTERCTOMIA EM LEITOA (Sus scrofa domesticus)
Authors: Marques da Silva Caroline , Andrade Fernandes Racquel , Cavalcanti Balençuela Caio , Futema Fabio , De Souza Ramos Angrimani Daniel , Rodrigues Soares Milena , Rodrigues Ambrosio Simone , Augusto Ferreira Marcio
Published: September 2021

A espécie suína nos últimos anos vem sendo espécie de escolha como companhia doméstica. Na Medicina Veterinária conhecemos o crescimento da suinocultura e as melhorias necessárias para o aumento da exportação. Melhorias na alimentação, melhoramento genético, no manejo e procedimentos cirúrgicos em machos. Pensando na domesticação desses animais e manutenção da saúde dessa espécie animal, além do manejo alimentar, se faz necessário novos estudos para a melhor adaptação desses animais e também o controle da reprodução em ambientes domésticos sem o interesse econômico da espécie. O procedimento cirúrgico para o controle da reprodução de fêmeas é a retirada dos ovários (ovariectomia) e poucos estudos foram descritos, tanto sobre o procedimento, quanto estudos comparativos para o melhor procedimento cirúrgico. A Ovariossalpingohisterectomia é um dos procedimentos cirúrgicos eletivos mais realizados na rotina veterinária de pequenos animais, sendo um meio eficaz no controle populacional e de prevenção de doenças. Devido à ausência de descrição da técnica cirúrgica em animais de produção, o presente trabalho relata o procedimento de Ovariossalpingohisterectomia realizado em leitoa (Sus scrofa domesticus) de aproximadamente quatro meses de idade, submetida a anestesia geral, com a avaliação pressórica e a hemogasometria, garantindo indicadores de bem estar animal e controle dos parâmetros vitais durante todo o procedimento, podendo ser alternativa para abordagens cirúrgicas de animais da espécie suína de companhia doméstica, conhecidos como minipig.