bluuebunny/crossref_metadata_2025 huggingface dataset:
BEHAVIORAL STUDIES OF WISTAR RATS IN ROTENONE INDUCED MODEL OF PARKINSON’S DISEASE
Authors: K. Srimathi Priyanga , K. Vijayalakshmi , R. Selvaraj
Published: November 2017

Objective: The objective of the study was to determine the behavioral activities of Wistar rats induced with rotenone. Methods: Thirty-six male Wistar rats were taken for the study and divided into six groups of six rats each. Group-I is the vehicle-treated, Group–II animals were induced with rotenone (3 mg/kg/bwt) by i. p. Group-III were co-treated with rotenone and L-DOPA (10 mg/kg/bwt) orally, Group-IV were co-treated with rotenone and quercetin (25 mg/kg/bwt) orally, Group-V were co-treated with rotenone and hesperidin (50 mg/kg/bwt) orally, Group-VI were treated with rotenone, quercetin and hesperidin in the same dosage regime for 60 d. The behavioural tests, such as open field test, ladder climbing test and hanging wire test were performed. The biochemical parameters such as urea, creatinine and activities of ALT and AST were also analysed.Results: All data are expressed as the mean±SD. Disability was noted in the behaviour of rats induced with Parkinson’s disease (PD). The deficits in behavioral activity were significantly changed when compared with an induced group (p<0.001) and biochemical parameters due to rotenone were significantly (p<0.001) restored by co-treatment with quercetin and hesperidin.Conclusion: In our in vivo study, we have demonstrated the combination of quercetin and hesperidin to serve as neuroprotective compounds by improving the behavioral abnormalities and restoring the biochemical parameters. Hence, these powerful antioxidants may protect brain cells.
PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF A T/TN SPECIFIC LECTIN FROM LEPECHINIA BULLATA SEEDS (LAMIACEAE)
Authors: A. Wilches Torres , J. Rojas Caraballo , E. Sanabria , E Reyes MontaÑo , Jl FernÁndez Alonso , A. Varrot , A. Imberty , N. Vega
Published: November 2017

Objective: This study focused on purifying and characterizing a lectin from Lepechinia bullata (L. bullata) seeds, and determining its specificity towards tumour-associated carbohydrate-antigens.Methods: Pigments were removed by washing the seeds with NH4OH 0.1 M pH 9.4 and treating the crude extracts with Pectinex®. The purification procedure consisted of anion exchange chromatography on diethylaminoethyl (DEAE)-Sephadex followed by affinity chromatography. For the characterization, the phase was used polyacrylamide gel electrophoresis-sodium dodecyl sulphate (SDS-PAGE), isoelectric focusing, hemagglutination assays, enzyme-linked lectinosorbent assay (ELLA) and thermal shift assay (TSA).Results: 6.2 mg of lectin were obtained from 100 g of seeds. It was able to agglutinate enzymatically treated erythrocytes with a minimal required lectin concentration of 7 μg. ml-1. Strong binding to asialo bovine submaxillary mucine (aBSM) was determined, corroborating Tn recognition.The isoelectric focusing showed a unique band at pH 8.5. Lectin pure shown bands at 28, 48 and 93 kDa by SDS-PAGE, with an incomplete dissociation of the last species despite trying several reduction conditions. By preparative electrophoresis under different conditions, three species were observed too, in all fractions one band at 28 kDa on Tricine-PAGE in reducing and no reducing conditions were found.Amino acid composition, carbohydrate content, thermal stability and Ca2+and Mn2+requirements were determined. N-acetylgalactosamine (GalNAc) and desialylated mucins inhibited the agglutinant activity on human cells. Fetuin inhibited hemagglutination of rabbit erythrocytes.Conclusion: A new lectin was isolated and characterized from L. bullata seeds, it recognizes T/Tn antigen and shows some similarities with other Lamiaceae lectins.
AMELIORATIVE EFFECTS OF PHYTOANDROGEN AND ANTIOXIDANT ON HISTOARCHITECTURE OF PERMETHRIN INDUCED CHANGES IN GOAT TESTIS
Authors: Bhardwaj Shivani , Sharma Rajnesh K
Published: November 2017

Objective: Protective effects of Tribulus terrestris (TT) and vitamin C were studied against permethrin induced changes in the histoarchitecture of goat testis.Methods: Hydroalcoholic extract of the fruits of Tribulus terrestris was prepared by maceration method and the extractive value was calculated. Fresh stock solution of permethrin (1mg/ml) in dimethyl sulphoxide and Tribulus terrestris (1mg/ml) in distilled water were prepared. Testicular tissues were cultured in TCM-199 nutrition media at 39℃ with 95% humidity and 5% CO₂ in the CO₂ incubator. Cultured testicular tissue was grouped as control having only the nutritive media, experimental group I(EI) received two doses of permethrin (100µg/ml and 200µg/ml), experimental group II(EII) was administered doses of permethrin along with vitamin C(0.1µM/ml) and experimental group III(EIII) was supplemented with doses of permethrin along with Tribulus terrestris (100µg/ml). All the groups were tested for 4 hr. and 8hr. for histoarcitectural studies.Results: Histological alterations were observed such as distorted shape of seminiferous tubules, decreased luminal and interstitial space, reduction in the population of spermatocytes, spermatozoa and spermatids in treated (E1) group as compared to control group. Maximum damage was detected at a higher dose of permethrin (200µg/ml) for 8h in contrast to lower doses (100 4h and 8h). Thus, it is concluded that permethrin has both dose and time-dependent effects. Protective groups (E2 and E3) imparted ameliorative effects by reestablishing shape of seminiferous tubules, decreasing luminal and interstitial space, increased population of spermatocyte, spermatozoa, and spermatids as compared with treated groups (E1)Conclusion: It has been reported that permethrin affects male fertility by inducing detrimental changes in the structure and function of seminiferous tubules. Both vitamin C and TT have the ability to mitigate the effect of pesticide. TT shows aphrodisiac activity against permethrin induced alterations in goat testis.
PANTULAN (REFLEKS) PROTO AUSTRONESIA (PAN) KE PROTOBAHASA KABOLA, PROTOBAHASA HAMAP, DAN PROTOBAHASA KLON DI PULAU ALOR, NUSA TENGGARA TIMUR
Authors: Iran Adhiti Ida Ayu
Published: November 2017

[Title: The reflexion of proto Austronesia to Kabola, Hamap, and Klon protolanguage in Alor Island, Nusa Tenggara Timur] Making data of the local languages in Nusa Tenggara Timur need to be observed, especially the local languages in Alor Island. The observer analyses the data collection in the languages of Kabola, Hamap, and Klon by the study of comparative historic linguistic.This observation uses synchronous approach, to know the language development in a period. This study is based on the result of PAN reconstruction of experts, such as: Demwolff, Dyen, Blust, Lopez, compiled by the list of Austronesia reconstruction composed by Wurm and Wilson. Comparative method used in this observation is sin comparative, to find the characteristics of similarity and the difference between relative languages that are alive in the same period. The language phenomena that is analysed is descriptive, firstly the data that is collected is the data of nowdays period. Reflection of PAN to Protolanguage Kabola, Hamap, and Klon (PKbHpKl) are found reflection of vocal phoneme PAN, vocal series of PAN, consonant phoneme of PAN, and cluster of consonant PAN on PKbHpKl. Some phonemes are reflected from Proto PAN to Protolanguage Kabola, Hamap, and Klon show that the three languages are derivativeof Proto PAN and Austronesia.
OFFENSIVE LANGUAGES IN BAD BOYS 2
Authors: Astu Mahayana I Made
Published: November 2017

This research focuses on the forms of offensive language and the functions in social context found in Bad Boys 2 movie. The writer applied some methods, such as data source, data collection, and data analysis. The data source of this research was Bad Boys 2 movie’s script. The movie is chosen because there are many expressions consisting of offensive language. The library research technique was used in collecting the data by quoting the sentences that support the topic of discussion. In analyzing the data, the writer applied the offensive language theory proposed by Timothy Jay (1992) in his book entitled Cursing in America and the theory of speech function proposed by Janet Holmes (1992) in his book entitled An Introduction to Sociolinguistics as the main theory. The analysis in this paper was also supported by other references which are related to this topic. The result of this research shows that there are only eight forms found in the data source. They are cursing, profanity, taboo, obscenity, vulgarity, slang, epithets, insult and slur.
MODERNIZATION OF THE PLAIN BEARING UNIT
Authors: Perekrestov Arshavir Petrovich , Mambetov Eldar Muslimovich , Saidov Muslim Abdullayevich
Published: November 2017

The article touches upon the main problems of reliability and durability of plain bearing units. The review of literature on the constructions of plain bearing units has been given, the main shortcomings of such constructions have been revealed. A description of the modernized design of a plain bearing unit using permanent linear magnets has been presented. The characteristics of neodymium magnets are listed. The operation principle and the design of the modernized plain bearing unit have been described. Its main advantages have been listed and compared with other plain bearing units. The use of the proposed device makes it possible to increase durability and reliability of the plain bearing unit.
PENGARUH FAMILY CONTROL DAN FOREIGN OWNERSHIP PADA PELAPORAN KEUANGAN DI INTERNET
Authors: Kumara Nenggalih Paksi
Published: November 2017

Abstract
This study aims to analyze and to obtain empirical evidence about the
influence of family control and foreign ownership on the reporting of financial information on the internet. This study differs from other studies due to the regulation of BAPEPAM-LK, which requires companies to upload their financial information the website of company. Apart from two main variables, this study also examines the effect of several control variables such as company size, profitability and leverage. In this study internet financial reporting is measured by using an index of disclosure consists of 78 items. Samples procedures in this study is purposive sampling method that produces a sample 140 companies listed
on the Stock Exchange in 2014. The method of data analysis of this study is multiple linear regression analysis. These results indicate that family control and size have a positive and significant association with internet financial reporting. On the other hand, foreign ownership, profitability and leverage indicates insignificant association with internet financial reporting.
STATE OF THE ART OF CONFORMITY ASSESSMENT – INTERNATIONAL REGULATIONS
Authors: Stojanović Jasna , Majstorović Vidosav D
Published: November 2017

Conformity assessment activities facilitate market acceptance for manufacturers, importers, exporters and traders by providing confidence that applicable requirements are being met. There is no trade without conformity assessment. There is no competitive market without standards. There is no free movement of goods without harmonisation of requirements and mutual recognition. This article presents state of the art of conformity assessment and tries to look for the future challenges of development of conformity assessment and accreditation. It is still the crucial point that market players develop a common understanding of the requirements that have to be fulfilled. On markets where free movement of goods and services is possible, another challenge is how to obtain the maximum benefits from harmonisation of standards and accredited conformity assessment activities.
APPLYING DFMA TECHNIQUES IN THE DESING IN THE DESIGN AND MANUFACTURE OF WIND TUNNEL MODELS
Authors: Živković Srđan , Ćurčić Dušan
Published: November 2017

Applying DFMA (Design for Manufacturing and Assembly) principles is crucial in the process of designing models for wind tunnel testing. The design process, especially of models for measuring the pressure distribution, takes several months. Production of these models require a minimum couple of months; sometime even more. The manufacturing with defects are not allowed. Very narrow time limits, defined by a contract, do not leave enough time for reworking. Very often, designers may not have knowledge of manufacturing rules and best practices - resulting in slower product development cycles, increased ECO/MCO (Engineering Change Order / Manufacturing Change Order), significant material waste and lower production yields. Manual reviews of Design or consultations with manufacturing experts are time consuming. Whole process need for proximity between design and manufacturing engineers. Design engineers need quick and interactive feedback while designing, integrated access to company’s manufacturing knowledge repository. This paper presents an automated application DFMA principles, applying the rules defined in the prototype production of wind tunnel models in Military Technical Institute.
QUALITY OF TELECOMMUNICATION COMPANIES SERVICES AS AN IMPERATIVE OF COMPETITIVE ADVANTAGE
Authors: Lekić Nemanja
Published: November 2017

In order to to be leaders in their respective business areas, modern business companies should follow the trends of the fast development of modern technologies and to implement them into its business wi th the aim to achieve and maintain competitive advantage. The aim of this paper is to highlight the quality of services as a vital prerequisite for competitive advantage. Mobile operators operating in the territory of the Republic of Serbia, the services they provide, as well as customer satisfaction will be described in this paper.
ISO/DIS 9004 - QUALITY OF AN ORGANIZATION – GUIDANCE TO ACHIEVE SUSTAINED SUCCESS
Authors: Isaac Sheps
Published: November 2017

The success factors of organizations are developing continuously and every few year’s new success factors are added to the complex demanding and ever-changing competitive environment in which organizations operate. There is no doubt that the primary focus of an organization should be to achieve higher satisfaction of its customers by implementing rigorous processes to continuously improve its products and services quality - but in the current competitive environment this is not enough to achieve sustained success and all interested parties needs and expectations have to be met. Organizations have to implement an effective and efficient management system that is led by top management and is focused on the organization ability to meet the needs and expectations of its customers and other relevant interested parties, over the long term as the way to achieve sustained success of the organization. Doing so organizations are moving from product quality which is the scope of ISO 9001 to quality of an organization which is the scope of the new ISO 9004 which has reached these days the level of draft of international standard (DIS) and is planned to be published in 2018 and will provide a guidance to organizations on how to achieve sustained success.
INTER-LABORATORY REPRODUCIBILITY OF BIOANALYTICAL UHPLC-MS/MS METHOD
Authors: Tubić Biljana K. , Vladimirov Sandra S. , Marković Bojan D.
Published: November 2017

Method validation is a continuous process, as a part of a perpetual analytical method development and improvement. Requirements for full validation are defined by various guidelines. Nevertheless, partial validation and method transfer are not so clearly described and well defined.The aim of this study was to examine method transferability through full validation method transfer between two different laboratories and to demonstrate if this approach can be regarded as sufficient for cross-laboratory results comparison.Method transfer was done from the originator laboratory to the recipient laboratory on two UHPLC-MS/MS instruments of approximately the same technical characteristics. The developed quantitative method was validated on both instruments by taking into account selectivity, linearity, accuracy, precision, limit of quantitation, recovery, matrix effects and stability in accordance with the regulatory guidance/guideline. Also method comparison by Passing-Bablok regression analysis was done.The reproducibility and cross-laboratory transferability of the UHPLC-MS/MS method for future non-clinical study was proven.As an epilogue to this study, authors recommend for the method transfer to be implemented in future in-house standard operating procedures (SOPs) related to analytical method validation process.
REALISATION OF THE METHOD FOR TESTING THE TYPE AND VERIFICATION OF COMPRESSED GASEOUS FUEL MEASURING SYSTEMS FOR VEHICLES
Authors: Mićić Ljiljana , Tanasić Branislav , Ivanović Radomir
Published: November 2017

Directorate of Measures and Precious Metals developed Rulebook on compressed gaseous fuel measuring systems for vehicles, published in “Official gazette of RS”, No. 9/2014, which represents transposition International recommendation OIML R139 of International organization for legal metrology into metrological legislation in Republic of Serbia. Thus, legal conditions were created for development and realization of the method for testing the type and verification of these measuring systems. The method of direct comparison measuring system with standard equipment was realized. DMDM purchased standard equipment within EU Project „Support of the quality infrastructure in Serbia” and Project of technical cooperation with national metrology institute in Germany (P TB -Physikalisch-Technische Bundesanstalt), Technical cooperation project – PTB number 95089. Validation of the method and suitability of the equipment in conditions of use and training of the inspectors was carried out, and the method is validated and verified. In this work basics of the method and specification of the used measuring equipment are presented.
PROLAB SOFTWARE FOR DATA EVALUATION OF INTERLABORATORY STUDIES
Authors: Bebić Jelena M , Gažević Luka S , Bläul Christian
Published: November 2017

Interlaboratory studies represent a form of external quality control for laboratories. International standards that are used for interlaboratory comparisons, ISO 17043, ISO 13528, ISO 5725, define ways of organisation of comparisons and data treatment of participating laboratories’ results. Intercomparison results can be exploited, apart from the main goal for laboratory performance evaluation, also for method validation and production of Certified Reference Materials. PROLab is a comprehensive, globaly accepted and standardized software package for evaluating interlaboratory studies. It provides large data set structures, graphical andcomputational methods for optimal use of the data. Directorate of Measures and Precious Metals has purchased and installed software package PROLab Plus, licenced as the only one in the Republic of Serbia. As such, it will be available to all interested organisers of interlaboratory comparisons, in our country.
THE IMPACT OF THE ECONOMIC CRISIS TO THE QUALITY OF SERVICES, OFFERED BY HIGHER EDUCATIONAL INSTITUTIONS WITH RESPECT TO STUDENT`S SATISFACTION
Authors: Angeli Ioannis , Kyriacou Agathi
Published: November 2017

Worldwide and mainly in the European Union many standards, regulations, models and systems exists for the evaluation of individual universities and Higher Education in General. All systems are targeting to measure or evaluate the Universities’ Quality Assurance Systems and the services offered to the recipients of higher education, mainly the students. Numerous surveys were conducted in the past either by each university or by organized bodies to identify the students’ satisfaction or to evaluate up to what extent these requirements are fulfilled. The question is “Are there any common requirements, parameters, good practices or questions that apply to a large number of universities that will assure that the society and students’ requirements are fulfilled?” Consequently, this opposes the main objective of this unique joint research which initiated in 2012 (Angeli I, Pilava Y. 2012) and repeated in 2017. Based on a review of the international literature and practices, an effort was made to explore the data and the challenges educational institutions are facing, the aspects of evaluation of educational institutions, the modern demands of students and stakeholders in universities. Furthermore, an investigation was made to identify up to what extent the students’ requirements and satisfaction are included in the most common university evaluation models and then how university authorities can accomplish those model requirements and on the same time the student’s requirements.In both case studies a detail internationally accepted questionnaire was used to evaluate up to what extent the students’ requirements and satisfaction were fulfilled in 2012 and five years later (2017). The questionnaire and methodology adopted, as well as the comparison tables and results will be very valuable to any university that is willing to follow the same route and methodology. It is important to say that Cyprus was and is still in Economic crisis. Twelve questions are related to effects of the economic crisis to their studies, programs etc. Consequently, someone can see and investigate the effects of the economic crisis in Higher education. A scientific tool and methodology is presented in this paper
IMPLEMENTATION OF INTERNET PLATFORM IN THE FUNCTION OF QUALITY IN MARKETING ACTIVITIES
Authors: Bulut-Bogdanović Ivana , Nešić Zoran , Popović Predrag , Radojičić Miroslav
Published: November 2017

This paper deals with some considerations on the use of Internet platform aimed at improving the quality of marketing activities of companies. The use of social networks is now an indispensable element which needs to be taken into account in modern business. Considering their prevalence and a large number of participants, social networks represent ideal platform for implementation of various marketing activities. In this paper the accent of considerations is placed on the consideration of their characteristics in terms of the possibility of their implementation in business of companies.
KEY COMPETITIVENESS FACTORS OF ISO CERTIFIED ORGANIZATIONS IN SERBIA
Authors: Lalić Bojan , Delić Milan , Tasić Nemanja , Marjanović Uglješa , Bogojević Branislav
Published: November 2017

Process of joining European Union implies adapting to new business conditions and improving the competitiveness of Serbian companies in order to be able to compete on equal terms in the European market. Implementation of quality management systems in manufacturing organizations is a significant advantage and it is one of the prerequisites for successful competition in open markets. In addition, implementation of ISO standards enables optimization of work processes and enhances competitiveness by resources optimization. This study, based on The European Manufacturing Survey (EMS) questionnaire, analyses competitiveness of Serbian companies through implementation of ISO 9001. The study has shown notable difference between certified and non-certified organizations in perception that product quality is the most important competitiveness factor.
RISK MANAGEMENT AND STRATEGIC PLANNING
Authors: Pavićević Snežana , Živković Vida , Stanković Tijana
Published: November 2017

Companies are exposed to a variety of risks related to the development and implementation of the business strategy. It is possible to observe an opportunity to analyze how different kinds of risk information can be objectively considered by senior management in order to enhance corporate governance and have sound decision making processes. Strategy formulation is the main part of the strategic planning process. Most common strategic planning tools do not even take risk into account, which worsens the situation. Subsequently, it is time to identify and measure strategic risks. Risk management may also support the development of institutional actions so as to increase the likelihood of reaching the expected results. Therefore, this paper aims to introduce a new comprehensive model which integrates risk management into strategic planning. A number of risk tools, improvements to be made by risk managers and a practical application of the model are presented in order to make possible the establishment and deployment of an effective strategy by the organization. The paper also describes the importance of strategic planning and management for the existence and development of enterprises and business organizations.
UNCERTAINTY ASSESSMENT AND QUALITY CONTROL FOR ENVIROMENTAL MEASUREMENTS OF TRITIUM IN WATER SAMPLES
Authors: Lekić Marija , Zdjelarević Nevena , Arbutina Dalibor , Lazarević Nataša
Published: November 2017

The main aim of this paper was to evaluate uncertainty for low level tritium measurements in monthly precipitation collected at PC NFS site and to clarify quality control procedures which provide reasonable assurance that the analytic results obtained are valid and accurate. Determination of tritium concentration in precipitation sample was conducted using liquid scintillation counter Quantulus 1220. The most important sources of uncertainty are discussed. Four different internal quality control methods have been presented and explained in detail.
BUSINESS PROCESS MODEL DEVELOPMENT IN QUALITY IMPROVEMENT
Authors: Nešić Zoran , Popović Predrag , Radojičić Miroslav , Ljubić Leon
Published: November 2017

This paper emphasizes the importance of developing information systems aimed at improving quality of operations. It is presented the basic and most important steps which are the basis for the formation of information systems. An example which is illustrated in this paper refers to the modeling of business processes and relational databases. The importance of proper and documented business process model is reflected in the consistency of the flow of information, data models and activities and their clear perception. It can be considered that the present step is the basis for the further implementation of information technology. In line with this consideration, this paper aims to highlight the importance of the problem presented in the function of improving quality of operations. The presented methodological framework can be universally applied as a starting point for the design of information systems relating to the segment of building permits issuing.
Atypical Fibroxanthoma of the External Ear: Case Report and Review of Literature
Authors: Nyckowski Timothy , Ceilley Roger , Bean Andrew
Published: November 2017

Atypical fibroxanthoma (AFX) is a rare, dermal- based mesenchymal neoplasm. Clinically, these tumors are characterized by rapid, exophytic growth and epidermal ulceration.1 Despite striking clinical features and growth pattern, it is considered to be a tumor of low- to intermediate- malignant potential.1-3. We report a case of an 89 year old Caucasian male that had a 1 month history of a rapidly enlarging, pedunculated neoplasm on the scapha of his right ear. Histologic and immunohistochemical analysis of the lesion were consistent with atypical fibroxanthoma. After a biopsy, the patient underwent a complete resection with Mohs micrographic surgery and remains asymptomatic 6 months later. This 3.0 x 2.0 cm lesion emerged over a 4-5 week period, representing the most rapid growing AFX of the external ear reported in the literature.
Ingenol Mebutate 0.06% Gel for Field Treatment of Actinic Keratosis on 250 cm2 of Skin on Trunk and Extremities: A Randomized Dose-Finding Trial
Authors: Siegel Daniel , Tanghetti Emil , Brody Neil , Freeman Michael , Skov Torsten , Petersen Astrid , Clonier Fabrice , Spelman Lynda
Published: November 2017

Background: Field treatment of actinic keratosis (AK) can eradicate clinical and sub-clinical lesions; treatments for extended skin areas are required.Methods: This randomized, double-blind, vehicle-controlled trial (NCT01998984) evaluated ingenol mebutate (IngMeb) 0.06% gel for AK treatment over extended areas. Adults with 5–20 AK lesions within a 250 cm2 area of skin on the trunk (except chest) or extremities were randomized to: 2 days vehicle, 2 days IngMeb (2D, n=55); 1 day vehicle, 3 days IngMeb (3D, n=59); 4 days IngMeb (4D, n=49); or 4 days vehicle (n=61). Week 8 primary endpoint was complete clearance of AK lesions; secondary endpoints included reduction in AK count and partial clearance. Adverse events (AEs) were recorded and local skin responses (LSRs) assessed. A hierarchical testing scheme, starting with 3D versus vehicle, was used.Results: In total, 224 patients were randomized. At Week 8, for 2D, 3D, 4D, and vehicle groups, complete clearance rates were 12.7%, 5.1%, 26.8%, and 0.0% (3D vs. vehicle, p=0.18); reductions in AK count were 63.0%, 66.8%, 73.6%, and 11.9%, respectively. LSR scores peaked at Day 5 (3D and 4D), and Days 5 and 10 (2D). Application-site pain and pruritus were common AEs. Of 15 neoplasm AEs, 14 were designated keratoacanthomas and one squamous cell carcinoma by central pathological review. The 4D group was closed based on pre-defined criteria.Conclusions: All three regimens were effective at reducing AK count on trunk/extremities. The 4D treatment was not well tolerated. Complete clearance was not significantly different to vehicle.
Binding Modes of Ligands Using Enhanced Sampling (BLUES): Rapid Decorrelation of Ligand Binding Modes Using Nonequilibrium Candidate Monte Carlo
Authors: Gill Samuel , Lim Nathan M. , Grinaway Patrick , Rustenburg Ariën S. , Fass Josh , Ross Gregory , Chodera John D. , Mobley David
Published: November 2017

Accurately predicting protein-ligand binding is a major goal in computational chemistry, but even the prediction of ligand binding modes in proteins poses major challenges. Here, we focus on solving the binding mode prediction problem for rigid fragments. That is, we focus on computing the dominant placement, conformation, and orientations of a relatively rigid, fragment-like ligand in a receptor, and the populations of the multiple binding modes which may be relevant. This problem is important in its own right, but is even more timely given the recent success of alchemical free energy calculations. Alchemical calculations are increasingly used to predict binding free energies of ligands to receptors. However, the accuracy of these calculations is dependent on proper sampling of the relevant ligand binding modes. Unfortunately, ligand binding modes may often be uncertain, hard to predict, and/or slow to interconvert on simulation timescales, so proper sampling with current techniques can require prohibitively long simulations. We need new methods which dramatically improve sampling of ligand binding modes. Here, we develop and apply a nonequilibrium candidate Monte Carlo (NCMC) method to improve sampling of ligand binding modes.

In this technique the ligand is rotated and subsequently allowed to relax in its new position through alchemical perturbation before accepting or rejecting the rotation and relaxation as a nonequilibrium Monte Carlo move. When applied to a T4 lysozyme model binding system, this NCMC method shows over two orders of magnitude improvement in binding mode sampling efficiency compared to a brute force molecular dynamics simulation. This is a first step towards applying this methodology to pharmaceutically relevant binding of fragments and, eventually, drug-like molecules. We are making this approach available via our new Binding Modes of Ligands using Enhanced Sampling (BLUES) package which is freely available on GitHub.
FINANCIAMENTO DA SAÚDE E PACTO FEDERATIVO
Authors: Vieitez Diego Losada , Corazza Ana Helena Scalco
Published: November 2017

A prestação de serviços públicos de saúde está estruturada em um Sistema Único, no qual participam financeiramente e têm competências próprias todos os entes federados. O presente estudo busca entender duas de suas principais disfunções: a participação relativa cada vez menor da União no financiamento, e o conflito gerencial entre controle pela União e autonomia dos Municípios. O objetivo é traçar um panorama compreensivo da evolução histórica desses problemas e apresentar propostas corretivas. O método de abordagem será o hipotético-dedutivo, o método de procedimento será o monográfico.
ANALYSIS LEARNING SOCIAL SCIENCE CHARGED THE VALUES OF ENTREPRENEURSHIP IN PRIMARY SCHOOL (Case Study in Social Science Education in Class IV SDPN Pajagalan 58 Bandung)
Authors: Iskandar Dadang , Allolinggi Lutma Ranta , Hamdani Acep Roni
Published: November 2017

Entrepreneurship education is a government program that is conducted every level of education. Implementation of the values of entrepreneurship learning in primary schools is an effort to promote entrepreneurship, so that people can develop into a reliable personal and be the generation that can create jobs. This study aims to assess the extent to which the learning of Social Sciences can provide space in growing the value of entrepreneurship in primary school students. This research was conducted in SDPN Pajagalan 58 with qualitative approach case study method. The subject is the person responsible for entrepreneurship education program, one teacher of Social Sciences and seventeen students of class IV. Based on the survey results revealed that entrepreneurship education program has been designed as possible into school programs that are implemented on an ongoing basis. The values of entrepreneurship has been published in school activities such as extracurricular activities, events and activities programmed habituation. Planning learning Social Sciences laden entrepreneurial values starting from the manufacture of the syllabus and lesson plans. Implementation of classroom learning is done in accordance with the lesson plan gives more space for students to develop a personality. Assessment of learning laden entrepreneurial values is done through observation and checks on student attendance. At the time of the learning takes place, the student has demonstrated an attitude / entrepreneurial character that is honest, self-discipline, confidence, leadership, creative, independent, hard work, responsibility, curiosity, communicative, and cooperation. The main problem is the plan that is prepared teacher is not maximized and not yet fully apply in learning. From the results of this study are expected to provide benefits for the development of entrepreneurship education in primary schools, especially in SDPN Pajagalan 58 and become material for the evaluation of Bandung City Education Department.
EFEK PENAMBAHAN JUS DAUN SIRIH (Piper bettle linn) SEBAGAI ADITIF PAKAN TERHADAP PERFORMA AYAM PETELUR
Authors: Haryuni Nining , Widodo Eko , Sudjarwo Edhy
Published: November 2017

Development of poultry has been done in terms of breeding, feeding and management. However, the implementation still faces many challenges such as the problem of production decrease. One cause of the decline in production is a health disorder caused by pathogenic bacteria (Salmonella sp and Escherichia coli). One way to overcome the problem is the use of Piper bettle linn Juice as a feed additive. The purpose of this study is to determine the effect of Piper bettle linn Juice as a feed additive to the performance of laying hens. The method used is the biological test of laying hens age 69 weeks of Isa Brown Strain of 250 laying hens, using Completely Randomized Design (RAL) with 5 treatments and 5 replications. The results of the research showed that Piper bettle linn Juice gave no significant effect (P> 0,05) to feed consumption and mortality. Influence significantly (P<0,01) to Hen Day Production (HDP), egg weight and Feed Conversion Ratio (FCR).
Efektivitas Media Huruf Bergambar Terhadap Kemampuan Menulis Permulaan Bagi Siswa Tunagrahita Ringan
Authors: Ayu Riska
Published: November 2017

Tujuan penelitian ini adalah (1) untuk mengetahui kemampuan menulis permulaan siswa tunagrahita ringan kelas I SDLB BC Kepanjen Kabupaten Malang sebelum diberikannya perlakuan, (2) untuk mengetahui kemampuan menulis permulaan siswa tunagrahita ringan kelas I SDLB BC Kepanjen Kabupaten Malang sesudah penggunaan media huruf bergambar, (3) untuk mengetahui efektivitas media huruf bergambar terhadap kemampuan emnulis permulaan siswa tunagrahita ringan kelas I SDLB BC Kepanjen Kabupaten Malang. Penelitian ini menggunakan metode penelitian eksperimen dengan desain One Group Times Series Desain. Hasil penelitian menunjukkan ada pengaruh media huruf bergambar terhadap kemampuan menulis permulaan siswa tunagrahita ringan kelas I SDLB BC Kepanjen Kabupaten Malang.
Pengaruh Penerapan Model Penemuan Terbimbing Berbantuan Power Point terhadap Hasil Belajar Materi Trigonometri Siswa Kelas X
Authors: Setiawan Bayu
Published: November 2017

Permasalahan pembelajaran di kelas dapat diatasi dengan desain pembelajaran yang merangsang siswa untuk belajar mandiri, lebih aktif, dan kreatif sesuai dengan kenyamanan siswa dalam belajar dan dibantu dengan kemapuan teknologi. Tujuan dari penelitian ini adalah untuk mengetahui ada tidaknya dan besar pengaruh model pembelajaran penemuan terbimbing (guided discovery) berbantuan powerpoint terhadap hasil belajar matematika siswa materi trigonometri kelas X. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksperimen semu. Hasil penelitian disimpulkan bahwa, ada pengaruh positif dan signifikan model pembelajaran penemuan terbimbing (guided discovery) berbantuan powerpoint terhadap hasil belajar matematika materi trigonometri siswa kelas X MIA MAN Kota Blitar dengan kategori sedang yaitu 76%.
Bagian Depan
Authors: Redaksi Dewan
Published: November 2017

Bagian Depan
Petunjuk Bagi Penulis
Authors: Redaksi Dewan
Published: November 2017

Petunjuk Bagi Penulis
Implementasi Integrasi Tani Tenak (Studi Kasus di Desa Ngino Kecamatan Plemahan Kabupaten Kediri)
Authors: Solikin Nur
Published: November 2017

Pertumbuhan ekonomi masyarakat pedesaan akan bisa terangkat jika pola pengembanga dilakukan melalui pengintegrasian sektor pertanian dan peternakan menjadi salah satu aktifitas ekonomi yang saling mengutungkan dan diikuti dengan merintis berdirinya koperasi ternak. Kegiatan ini bertujuan mengetahui tingkat pengetahuan dan ketrampilan anggota kelompok tani/ternak dalam memanfaatkan limbah pertanian untuk peternakan dan pemanfaatan limbah peternakan untuk sektor pertanian.Metode yang digunakan dalam kegiatan ini partisipatoris, Masyarakat tidak dilihat sebagai obyek melainkan subyek dari pembangunan yang dilakukan, sehingga penekanan partisipasi dari masyarakat, dalam mendapatkan data diperoleh dari anggota kelompok tani dan ternak melalui wawancara dan angket.Responden sejumlah 60 (anggota kelompok tani dan ternak) menyatakan bahwa 10 persen dari anggota kelompok ternak yang sudah memanfaatkan limbah pertanian diproses menjadi pakan ternak dan 90 persen memanfaatkan limbah ternak tanpa diproses atau hanya disimpan atau langsung diberikan ke ternak. Dalam pemanfaatan limbah peternakan 5 persen yang mengolah limbah ternak menjadi pupuk bokasih dan 75 persen tidak diolah dibiarkan saja kalau kering langsung dibuang di lahan pertanian dan 20 persen yang lain diganti/jual kepada yang membutuhkan. Simpulannya adalah pola pengintegrasian sektor pertanian dan peternakan di Desa Ngino Kecamatan Plemahan Kabupaten Kediri masih kurang dan sangat perlu dikembangkan,ditingkatkan keterampilan masyarakatnya sehingga ekonomi pedesaan bisa tumbuh secara optimal.
Metode Belajar Menurut Imam Zarnuji: Telaah Kitab Ta’lim Al Muta’alim
Authors: Shofwan Arif Muzayyin
Published: November 2017

Sebelum para pakar Barat memperkenalkan metode belajar kepada dunia secara luas, sebenarnya Islam sudah memiliki metode belajar sendiri untuk para pelajar. Metode belajar tersebut telah ditulis oleh salah satu intelektual muslim abad pertengahan yang bernama Imam Zarnuji dalam kitab berjudul Kitāb Ta’līm al-Muta’allim. Tulisan ini bertujuan menelaah sekelumit biografi Imam Zarnuji dan metode belajar yang ditawarkan. Adapun metode penulisan dalam penelitian ini menggunakan riset perpustakaan dengan mengambil berbagai literatur yang sesuai  dengan kajian. Tulisan ini menghasilkan dua temuan, yaitu: Pertama, Imam Zarnuji merupakan salah satu intelektual muslim abad pertengahan yang telah menulis metode belajar secara sistematis sebelum para pakar Barat memperkenalkan metode belajar modern. Kedua, dalam pandangan Imam Zarnuji, apabila para pelajar ingin sukses mendapatkan manfaat dari ilmu pengetahuan, maka ada dua hal yang harus dilaksanakan, yaitu: (1) hendaknya melakukan dengan benar ketika menapaki jalan atau metode dalam menempuh ilmu pengetahuan; (2) hendaknya melaksanakan syarat-syarat dalam menempuh ilmu pengetahuan. Dengan melaksanakan kedua hal tersebut, maka para pelajar akan mendapatkan ilmu pengetahuan serta mendapatkan manfaat ilmu pengetahuan yang dicita-citakan,
The Sustainable Development Goals and Information and Communication Technologies
Authors: Jones Peter , Wynn Martin , Hillier David , Comfort Daphne
Published: November 2017

The Sustainable Development Goals (SDGs) are a wide range of global sustainable development targets for the environment, society and economy and they were launched by the United Nations in 2015. In launching the SDGs, the United Nations called on all member states to embrace what are an ambitious and demanding set of challenges but it also emphasised the vital role that businesses, would have to play if these challenges were to be met. The aim of this preliminary commentary paper is to review a number of the ways the Information Communication and Technology industry believes it can contribute to the achievement of the SDGs. The paper outlines the characteristics of the concept of sustainable development and how ICT relates to sustainable development, reviews a number of the ways two leading ICT companies, namely Ericsson and Microsoft and two industry bodies, namely the GSMA which represents the interests of mobile operators worldwide, and the Global e-Sustainability Initiative, believe they can contribute to the achievement of the SDGs. The paper also examines some of the challenges the industry may face in making such a contribution and offers some reflections on the role of ICT in promoting the transition to a more sustainable future for people and the planet.
A Simplified Method for the Design of Steel Beam-to-column Connections
Authors: Kristóf Imola , Novák Zsanett , Hegyi Dezső
Published: November 2017

The moment resistance of beam-to-column connections is frequently utilised in steel structures. Eurocode 3 suggests the component method to analyse such connections, and it implements the equivalent T-stub method to determine the resistance of the end plate of the beam. The latter method requires tedious and concentrated work. A simplified method is suggested to reduce the number of calculations and enable the designer to focus on construction aspects in the pre-design phase, or in education.The resistance of the T-stub covers three possible failure modes: the yield of the plate, the failure of the of the bolt and simultaneous yield. The yield of the plate and simultaneous yield depend on numerous parameters, and they are verified by multiple equations. The failure of the bolts are more easily checked.In the present paper, requirements for geometric ratios are defined for the widely used steel sections to assure failure of the bolts at a lower level of the load than the yield of the plate. These parameters facilitate the simple calculation of the resistance of the bolts instead of the tedious work needed for the end plate resistance.The paper presents a proper explanation for the design rules and the effect of the geometric parameters on the resistance of the end plate. Geometric parameters are suggested for the widely used hot rolled and typical welded beam sections. All the parameters fulfil the requirements of the equivalent T-stub method of Eurocode 3.
Experimental Study of Real-Time Classification of 17 Voluntary Movements for Multi-Degree Myoelectric Prosthetic Hand
Authors: Jiralerspong Trongmun , Nakanishi Emi , Liu Chao , Ishikawa Jun
Published: November 2017

The myoelectric prosthetic hand is a powerful tool developed to help people with upper limb loss restore the functions of a biological hand. Recognizing multiple hand motions from only a few electromyography (EMG) sensors is one of the requirements for the development of prosthetic hands with high level of usability. This task is highly challenging because both classification rate and misclassification rate worsen with additional hand motions. This paper presents a signal processing technique that uses spectral features and an artificial neural network to classify 17 voluntary movements from EMG signals. The main highlight will be on the use of a small set of low-cost EMG sensor for classification of a reasonably large number of hand movements. The aim of this work is to extend the capabilities to recognize and produce multiple movements beyond what is currently feasible. This work will also show and discuss about how tailoring the number of hand motions for a specific task can help develop a more reliable prosthetic hand system. Online classification experiments have been conducted on seven male and five female participants to evaluate the validity of the proposed method. The proposed algorithm achieves an overall correct classification rate of up to 83%, thus, demonstrating the potential to classify 17 movements from 6 EMG sensors. Furthermore, classifying 9 motions using this method could achieve an accuracy of up to 92%. These results show that if the prosthetic hand is intended for a specific task, limiting the number of motions can significantly increase the performance and usability.
Fine-Tuning Synthesis and Characterization of Mono-Sized H-Beta Zeolite-Supported Palladium-Iridium Nanoparticles and Application in the Selective Hydrogenation of Acetylene
Authors: Sahooli Masood , Rahimpour Mohammad , Khorram Mohammad
Published: November 2017

In this research, a mono-sized Beta zeolite support synthesized by the solvothermal method was used in the selective acetylene to ethylene hydrogenation reaction with minimum coke build up on the catalyst surface. Tetrapropylammonium hydroxide (TPAOH), tetrapropylammonium bromide (TPABr), n-butylamine, and morpholine were used as structure direct agents (SDA) in the support to obtain various shapes. The characterization results show that although the Si/(Al+SDA) ratio has no effect on the phase purity of support, it has a remarkable effect on porosity, crystal size, shape, and structure of micropores. After comparing characterization results, the developed support, based on TPAOH, was selected and modified by different metals (Ce, Ir, Ag, and Pd) using the incipient wetness co-impregnation method. Since there is an interaction between selectivity and conversion, the optimum metal content in the synthesized catalysts and reaction condition were determined to achieve the desired acetylene conversion and ethylene selectivity. The physicochemical transformation of the developed optimum catalysts was determined using different techniques. Based on the characterization and cata-test results, the catalyst which contains 0.29% Ir and 0.08% Pd presents a better performance and higher stability compared to the other catalysts due to the moderate size and mono layer dispersion of the metals on the support. The experimental results show that acetylene conversion and ethylene selectivity approach 97% and 92% at 55 °C, respectively.