bluuebunny/crossref_metadata_2025 huggingface dataset:
Jet noise shielding provided by a hybrid wing body aircraft
Authors: Doty Michael J , Brooks Thomas F , Burley Casey L , Bahr Christopher J , Pope Dennis S
Published: February 2018

One approach toward achieving NASA's aggressive N+2 noise goal of 42 EPNdB cumulative margin below Stage 4 is through the use of novel vehicle configurations like the hybrid wing body. Jet noise measurements from a hybrid wing body acoustic test in the NASA Langley 14- by 22-Foot Subsonic Tunnel are described. Two dual-stream, heated Compact Jet Engine Simulator units are mounted underneath the inverted hybrid wing body model on a traversable support to permit measurement of varying levels of shielding provided by the fuselage. Both an axisymmetric and low noise chevron nozzle set are investigated in the context of shielding. The unshielded chevron nozzle set shows 1–2 dB of source noise reduction (relative to the unshielded axisymmetric nozzle set) with some penalties at higher frequencies. Shielding of the axisymmetric nozzles shows up to 6.5 dB of reduction at high frequency. The combination of shielding and low noise chevrons shows benefits beyond the expected additive benefits of the two, up to 10 dB, due to the effective migration of the jet source peak noise location upstream for increased shielding effectiveness. Jet noise source maps from phased array results processed with the deconvolution approach for the mapping of acoustic sources algorithm reinforce these observations.
The perceptions and practices of school leaders in Christian Education National
Authors: Prior Christopher Michael
Published: February 2018

In Christian schools, leaders’ roles include the integration of the particular beliefs of the community through all aspects of school life. This article describes an interpretive study into school leaders’ perceptions of the essential features of Christian Education National (CEN) schools, how they integrated these features into school culture, and their understandings of the leadership by which they achieved this. This research identified that school leaders were aware of the beliefs of CEN. Despite leaders noting that these beliefs ought to be embedded holistically into school culture, the CEN services and resources available to support such inculcation were underutilized. Although servant leadership, shared leadership and vision-based leadership were all described in relation to CEN schools, the leadership within these schools is better understood as informed by the Christian faith rather than widely supported leadership theories mentioned in this study.
Factors influencing readthrough therapy for frequent cystic fibrosis premature termination codons
Authors: Pranke Iwona , Bidou Laure , Martin Natacha , Blanchet Sandra , Hatton Aurélie , Karri Sabrina , Cornu David , Costes Bruno , Chevalier Benoit , Tondelier Danielle , Girodon Emmanuelle , Coupet Matthieu , Edelman Aleksander , Fanen Pascale , Namy Olivier , Sermet-Gaudelus Isabelle , Hinzpeter Alexandre
Published: February 2018

Premature termination codons (PTCs) are generally associated with severe forms of genetic diseases. Readthrough of in-frame PTCs using small molecules is a promising therapeutic approach. Nonetheless, the outcome of preclinical studies has been low and variable. Treatment efficacy depends on: 1) the level of drug-induced readthrough, 2) the amount of target transcripts, and 3) the activity of the recoded protein. The aim of the present study was to identify, in the cystic fibrosis transmembrane conductance regulator (CFTR) model, recoded channels from readthrough therapy that may be enhanced using CFTR modulators.

First, drug-induced readthrough of 15 PTCs was measured using a dual reporter system under basal conditions and in response to gentamicin and negamycin. Secondly, exon skipping associated with these PTCs was evaluated with a minigene system. Finally, incorporated amino acids were identified by mass spectrometry and the function of the predicted recoded CFTR channels corresponding to these 15 PTCs was measured. Nonfunctional channels were subjected to CFTR-directed ivacaftor-lumacaftor treatments.

The results demonstrated that CFTR modulators increased activity of recoded channels, which could also be confirmed in cells derived from a patient.

In conclusion, this work will provide a framework to adapt treatments to the patient's genotype by identifying the most efficient molecule for each PTC and the recoded channels needing co-therapies to rescue channel function.
Connexin 30 controls astroglial polarization during postnatal brain development
Authors: Ghézali Grégory , Calvo Charles-Félix , Pillet Laure-Elise , Llense Flora , Ezan Pascal , Pannasch Ulrike , Bemelmans Alexis-Pierre , Etienne Manneville Sandrine , Rouach Nathalie
Published: February 2018

Astrocytes undergo intense morphological maturation during development, changing from individual sparsely branched cells to polarized and tremendously ramified cells. Connexin 30, an astroglial gap-junction channel-forming protein expressed postnatally, regulates in situ the extension and ramification of astroglial processes. However, the involvement of connexin 30 in astroglial polarization, which is known to control cell morphology, remains unexplored. We found that connexin 30, independently of gap-junction-mediated intercellular biochemical coupling, alters the orientation of astrocyte protrusion, centrosome and Golgi apparatus during polarized migration in an in vitro wound-healing assay. Connexin 30 sets the orientation of astroglial motile protrusions via modulation of the laminin/β1 integrin/Cdc42 polarity pathway. Connexin 30 indeed reduces laminin levels, inhibits the redistribution of the β1-integrin extracellular matrix receptors, and inhibits the recruitment and activation of the small Rho GTPase Cdc42 at the leading edge of migrating astrocytes. In vivo, connexin 30, the expression of which is developmentally regulated, also contributes to the establishment of hippocampal astrocyte polarity during postnatal maturation. This study thus reveals that connexin 30 controls astroglial polarity during development.
Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling
Authors: Troll Joshua V. , Hamilton M. Kristina , Abel Melissa L. , Ganz Julia , Bates Jennifer M. , Stephens W. Zac , Melancon Ellie , van der Vaart Michiel , Meijer Annemarie H. , Distel Martin , Eisen Judith S. , Guillemin Karen
Published: February 2018

Resident microbes promote many aspects of host development, although the mechanisms by which microbiota influence host tissues remain unclear. We showed previously that the microbiota is required for allocation of appropriate numbers of secretory cells in the zebrafish intestinal epithelium. Because Notch signaling is crucial for secretory fate determination, we conducted epistasis experiments to establish whether the microbiota modulates host Notch signaling. We also investigated whether innate immune signaling transduces microbiota cues via the Myd88 adaptor protein. We provide the first evidence that microbiota-induced, Myd88-dependent signaling inhibits host Notch signaling in the intestinal epithelium, thereby promoting secretory cell fate determination. These results connect microbiota activity via innate immune signaling to the Notch pathway, which also plays crucial roles in intestinal homeostasis throughout life and when impaired can result in chronic inflammation and cancer.
The Mechanism of Formation of the Strategy to Ensure the Financial Stability of the Enterprise
Authors: Егоркина Татьяна , Yegorkina Tatyana , Лазарева Инна , Lazareva Inna
Published: February 2018

The article considers theoretical bases of the strategy to ensure financial stability of the enterprise which is the basis for determining directions of organization of financial relations both in the internal environment of the enterprise and beyond. Various approaches of economists to the definition of enterprise strategy are investigated, which highlighted two approaches to the interpretation of this concept: disclosure strategies as a means of achieving the objectives of the entity and consideration of the strategy of the enterprise as a set of decision rules. The article displayed the author’s definition of strategy to ensure financial stability of the enterprise. The author describes the main tasks and principles, which must rely on the development of a strategy for financial stability. Sequence of formation of the strategy to ensure the financial stability of the company, consisting of ten stages are proposed.
Theoretical and Methodological Aspects of Estimation of Innovative Potential and Innovative Activity of the Enterprise
Authors: Синькова Ю. , Sin'kova Yu.
Published: February 2018

Innovation can be defined as the successful conversion of new concepts and knowledge into new products, services or processes that deliver new customer value in the market. Innovation is the specific instrument of entrepreneurship, the act of endowing resources with a new capacity to create profits. Innovation can be defined as “a step that creates a new dimension of performance”. Innovation is the embodiment, combination and/or synthesis of knowledge in new, relevant, valuable new products, processes or services. Innovation is the creation of something that improves our lives. A modern company needs to understand what is innovation and what is their dynamics. After all, innovation can determine the strategy, consistent with the goals of the organization and its vision. It is possible to identify another important concept for today’s businesses to be innovative, companies must pay attention to their future, i.e. innovation. The next step is the development and internalization of management tools innovation process. These solutions must be adapted to each specific situation. Consider the size of the company, its sector of activity, culture and organizational structure of the Agency system and the managerial vision of the future and ambitions of leadership. Understanding of the concept of innovation and its application in practice requires time, effort and investment. However, we all see that the company has become a truly innovative, you begin to lead. Innovative products are those that replace the current offerings or are based on them; they offer new features or other benefits that allow users to work more efficiently and/or less expensive.
Monetary Policy of Russia 2018–2020: the Course Is Taken on Stability
Authors: Смирнов Е. , Smirnov E.
Published: February 2018

In the beginning of the triennium of 2018-2020, Russia’s monetary policy pursued by the Central Bank of the Russian Federation will be primarily aimed at maintaining the achieved price and fi nancial stability in order to improve the living standards of the country’s population and meet the needs of the growing domestic economy.
Role and Location of Internal Control in the Management System of Autonomous Institutions
Authors: Турищева Татьяна , Turishcheva Tatyana
Published: February 2018

In this article, using the methods of system and comparative analysis, logical analysis, problems of the formation, role and place of the internal control system in autonomous institutions are analyzed. It was concluded that the formation of JMC in an autonomous institution should be carried out within the framework of a joint project to create both management accounting and, in fact, control, and the internal control service of an autonomous institution should be established at two levels of management, Level of the founder forming the task.
The Main Positive and Negative Aspects of the Implementation of the Law on Contract System
Authors: Денисенко Галина , Denisenko Galina , Краус И. , Kraus I.
Published: February 2018

The article is devoted to a three-year experience of implementation of the law on the contract system. The authors describe the main positive and negative points of the organization of the whole system of electronic trading from both a customer and supplier.
Using best practice to create tailored parasite control plans for pets
Authors: Stokes Laura , Wright Ian
Published: February 2018

Parasite control plans allow for the prevention and control of parasites to be tailored to individual pets after assessment. Every pet's requirements are different and so simple techniques are required which can be used to break down the assessment of pets into a user-friendly method, which enables veterinary staff to implement best practice. Veterinary nurses are well placed to implement these protocols by assessing risk, geographic location and lifestyle. This may be achieved in nurse clinics or as a more informal conversation at the reception desk or over the phone. By developing bespoke parasite control plans, client bonding to practices may be increased, while also increasing pet and human health by reducing parasitic disease risk. Following best practice is an excellent means of ensuring standards are met within practice and is often the starting point for accreditations. This article will focus on parasite control plans for cats and dogs and uses the ESCCAP (European Scientific Counsel Companion Animal Parasites) best practice guidelines as a means of reference.
Surgical skin preparation — are we just going around in circles?
Authors: Kerrigan Lynne
Published: February 2018

Aseptic care of the skin prior to any breach is of paramount importance to reduce the incidence of surgical site infection (SSI), as each time the skin is incised or punctured a portal of entry for microorganisms exists. The application of an appropriate skin preparation agent is significant, but arguably given less significance is the technique employed to apply the solution itself. Historically, concentric circles were the method of choice for aseptic skin preparation. More recently, a back-and-forth motion is being advocated within the National Health Service (NHS). This article will examine the current literature and seek to determine if evidence exists to support either method demonstrating greater efficacy.
Effects of interfacial micromotions on vitality and differentiation of human osteoblasts
Authors: Ziebart J. , Fan S. , Schulze C. , Kämmerer P. W. , Bader R. , Jonitz-Heincke A.
Published: February 2018

Objectives

Enhanced micromotions between the implant and surrounding bone can impair osseointegration, resulting in fibrous encapsulation and aseptic loosening of the implant. Since the effect of micromotions on human bone cells is sparsely investigated, an in vitro system, which allows application of micromotions on bone cells and subsequent investigation of bone cell activity, was developed.

Methods

Micromotions ranging from 25 µm to 100 µm were applied as sine or triangle signal with 1 Hz frequency to human osteoblasts seeded on collagen scaffolds. Micromotions were applied for six hours per day over three days. During the micromotions, a static pressure of 527 Pa was exerted on the cells by Ti6Al4V cylinders. Osteoblasts loaded with Ti6Al4V cylinders and unloaded osteoblasts without micromotions served as controls. Subsequently, cell viability, expression of the osteogenic markers collagen type I, alkaline phosphatase, and osteocalcin, as well as gene expression of osteoprotegerin, receptor activator of NF-κB ligand, matrix metalloproteinase-1, and tissue inhibitor of metalloproteinase-1, were investigated.

Results

Live and dead cell numbers were higher after 25 µm sine and 50 µm triangle micromotions compared with loaded controls. Collagen type I synthesis was downregulated in respective samples. The metabolic activity and osteocalcin expression level were higher in samples treated with 25 µm micromotions compared with the loaded controls. Furthermore, static loading and micromotions decreased the osteoprotegerin/receptor activator of NF-κB ligand ratio.

Conclusion

Our system enables investigation of the behaviour of bone cells at the bone-implant interface under shear stress induced by micromotions. We could demonstrate that micromotions applied under static pressure conditions have a significant impact on the activity of osteoblasts seeded on collagen scaffolds. In future studies, higher mechanical stress will be applied and different implant surface structures will be considered. Cite this article: J. Ziebart, S. Fan, C. Schulze, P. W. Kämmerer, R. Bader, A. Jonitz-Heincke. Effects of interfacial micromotions on vitality and differentiation of human osteoblasts. Bone Joint Res 2018;7:187–195. DOI: 10.1302/2046-3758.72.BJR-2017-0228.R1.
Effects of a phosphocitrate analogue on osteophyte, subchondral bone advance, and bone marrow lesions in Hartley guinea pigs
Authors: Sun Y. , Kiraly A. J. , Sun A. R. , Cox M. , Mauerhan D. R. , Hanley E. N.
Published: February 2018

Objectives

The objectives of this study were: 1) to examine osteophyte formation, subchondral bone advance, and bone marrow lesions (BMLs) in osteoarthritis (OA)-prone Hartley guinea pigs; and 2) to assess the disease-modifying activity of an orally administered phosphocitrate ‘analogue’, Carolinas Molecule-01 (CM-01).

Methods

Young Hartley guinea pigs were divided into two groups. The first group (n = 12) had drinking water and the second group (n = 9) had drinking water containing CM-01. Three guinea pigs in each group were euthanized at age six, 12, and 18 months, respectively. Three guinea pigs in the first group were euthanized aged three months as baseline control. Radiological, histological, and immunochemical examinations were performed to assess cartilage degeneration, osteophyte formation, subchondral bone advance, BMLs, and the levels of matrix metalloproteinse-13 (MMP13) protein expression in the knee joints of hind limbs.

Results

In addition to cartilage degeneration, osteophytes, subchondral bone advance, and BMLs increased with age. Subchondral bone advance was observed as early as six months, whereas BMLs and osteophytes were both observed mainly at 12 and 18 months. Fibrotic BMLs were found mostly underneath the degenerated cartilage on the medial side. In contrast, necrotic BMLs were found almost exclusively in the interspinous region. Orally administered CM-01 decreased all of these pathological changes and reduced the levels of MMP13 expression.

Conclusion

Subchondral bone may play a role in cartilage degeneration. Subchondral bone changes are early events; formation of osteophytes and BMLs are later events in the OA disease process. Carolinas Molecule-01 is a promising small molecule candidate to be tested as an oral disease-modifying drug for human OA therapy. Cite this article: Y. Sun, A. J. Kiraly, A. R. Sun, M. Cox, D. R. Mauerhan, E. N. Hanley Jr. Effects of a phosphocitrate analogue on osteophyte, subchondral bone advance, and bone marrow lesions in Hartley guinea pigs. Bone Joint Res 2018;7:157–165. DOI:10.1302/2046-3758.72.BJR-2017-0253.
Aplicação do método de fluorescência induzida por laser na caracterização de áreas contaminadas com resíduos oleosos
Authors: Krahenbuhl Fernando De Melo , Teramoto Elias Hideo , Kiang Chang Hung
Published: February 2018

A aplicação de perfilagem contínua, por meio do método de fluorescência induzida por laser (LIF), em uma área urbana com disposição pretérita de resíduos oleosos (superior a 30 anos), mostrou-se útil na delimitação tridimensional de resíduos oleosos em subsuperfície, indicando em tempo real e com baixo investimento a área passível de remediação. A comparação com dados obtidos por outras formas de investigação ambiental indica que o LIF é eficiente na detecção em campo, tanto de resíduos oleosos como de material oleoso impregnado no solo, independente do seu grau de intemperismo e da heterogeneidade na distribuição espacial. As respostas de fluorescência foram coerentes com o tipo de material encontrado, em que predominam hidrocarbonetos aromáticos policíclicos de cadeias maiores. O método foi sensível mesmo no caso de lentes delgadas de resíduos.
Contribuição ao conhecimento da hidráulica subterrânea do aquífero Jandaíra na região de Baraúna – RN
Authors: Demétrio José Geilson Alves , Batista Ana Gabriella dos Santos , Melo José Geraldo de
Published: February 2018

O aquífero Jandaíra, que ocorre na área da chapada do Apodi, entre os Estados do Rio Grande do Norte e Ceará, onde está inserida a área de estudo, é uma importante fonte de água para a irrigação de extensas áreas de fruticultura. Devido a sua natureza cárstica, a hidrogeologia é naturalmente bastante complexa. A compreensão da hidráulica desses aquíferos é de fundamental importância propiciar uma gestão mais efetiva, visando a sua preservação. Nesse sentido foram desenvolvidos estudos geológicos, geofísicos e hidrogeológicos, que mostraram que a carstificação diminui com a profundidade. Na área estudada a carstificação atinge até cerca de 30 metrosde profundidade. O trabalho também mostrou que a posição do nível d’água varia de acordo com o regime das chuvas. Nas épocas de grandes secas, como a última que durou seis anos, os níveis aprofundaram bastante e a maioria dos poços diminuíram a produtividade, ao ponto de não ser possível usá-los para irrigação, uma vez que, as vazões desses poços dependem da rede de carstificação superficial.
Aplicação do software Defluoridation no dimensionamento do sistema de desfluoretação de águas subterrâneas utilizando carvão ativado de osso granulado
Authors: Baumann Luiza , Klamt Rodrigo Augusto , Santos Ronaldo Bastos dos , Kirst Alcido , Helfer Gilson Augusto , Lobo Eduardo Alexis , Costa Adilson Ben da
Published: February 2018

A ingestão de água com níveis elevados de flúor provoca uma patologia denominada fluorose dental, que resulta da mineralização defeituosa da matriz do esmalte, diretamente associada à quantidade de água ingerida de altas concentrações de fluoretos. Neste contexto, foi desenvolvido um sistema de desfluoretação por adsorção em carvão ativado de osso, seguido por precipitação por contato através da adição de sais de cálcio e fósforo. Este sistema foi construído em um tanque (filtro) de Poly Glass® com revestimento de polietileno transparente de alta densidade, preenchido com 25 kg de carvão ativado de osso de diâmetro de partícula igual a 20 x 50 mesh. Para o dimensionamento do sistema foi desenvolvido um software denominado Defluoridation, que permite a determinação das dimensões do sistema e as vazões de reagentes para o processo de precipitação por contato. O sistema foi aplicado no tratamento de água subterrânea com concentração de flúor entre 2,4 e 3,0 mg.L-1. No total, 30.000 L de água foram tratados, dos quais 13.000 L pela técnica de adsorção, e depois 7.000 L, que foram filtrados para atingir valores próximos da água bruta, e 10.000 L pela técnica de precipitação por contato. Os resultados obtidos demonstram a eficiência da aplicação do software Defluoridation, destacando que a técnica de precipitação por contato é uma forma econômica e simples para o fornecimento de água.
Physico-chemical quality of waters of tubular wells located in the interior of the State of Rio Grande do Norte
Authors: Dantas Gerbeson Carlos Batista , Farias Henriqueta Monalisa , Oliveira Camila Rafaela Santos de , Silveira Arthuro Munay Dantas da , Barros Sâmea Valensca Alves
Published: February 2018

Este trabalho tem como objetivo realizar a caracterização físico-química da água de dois poços tubulares, no período de três meses, localizados na zona rural do município de Parelhas, Estado do Rio Grande do Norte, e posteriormente, analisar a viabilidade de utilização da água bruta para consumo humano. Em relação às analises físico-químicas, foram determinados 15 parâmetros, tanto para a amostra A, como para a amostra B, a fim de caracterizá-las: pH, condutividade elétrica, temperatura na fonte, bicarbonato (HCO3-), cloreto (Cl-), dureza total (CaCO3), dureza (Ca2+), dureza (Mg2+), alcalinidade, sólidos totais dissolvidos, oxigênio dissolvido, nitrogênio amoniacal, nitrito (NO2-), nitrato (NO3-) e ferro. De acordo com os ensaios, as águas sob análise, apresentaram discordâncias em relação a Portaria de Potabilidade 2914/2011 nos seguintes parâmetros: Alcalinidade, sólidos totais dissolvidos, nitratos, nitritos e ferro. Somando-se a isso, as águas foram classificadas como duras (amostra B) e muito duras (amostra A), apresentaram condutividade extremamente elevada, superior a 590 μS.cm-1 e baixo teor de oxigênio dissolvido. Por fim, este trabalho conclui, a partir dos resultados dos parâmetros físico-químicos da amostra A e amostra B, que as água brutas dos poços estão inapropriadas ao consumo humano.
Examination of Different Learning Conditions in the Testing Effect: Example of Safe Internet Use
Authors: UÇAR Beyza , DEMİRASLAN ÇEVİK Yasemin
Published: February 2018

Tests in educational setting are often seen as an assessment tool. However, in the field of psychology, memory related studies have shown that being tested affects recall in a positive way. Studying on a material as testing rather than studying on it many times helps better to remember the information in the material. This phenomenon is called Testing Effect. It is stated in the literature that using testing effect in the field of education may have positive result. It is thought that one of the important skills that should be gained to learners is the Safe Internet Usage. The aim of this study is to examine whether the different learning conditions (Study-Study-Test, Study-Test-Test, Study-Study-Study-Test and Study-Test-Test-Test) are influential for middle school students to learn the topic of Safe Internet Use. The research results show that different learning conditions have an effect on the group's short-term retention performance but not on long term retention.
Reasons of Preservice Teachers Attending the Pedagogical Formation Certificate Program for Choosing Teaching as a Profession
Authors: DENİZ Sabahattin , DOĞAN Uğur , ŞAHİN Nurettin
Published: February 2018

DOI: Due to social, economic and cultural conditions, preservice teachers’ reasons for choosing the teaching profession differ from country to country. The purpose of the current study is to determine the factors affecting the choices of prospective teachers in the process of preferring the profession of teaching. The participants of the study were 230 voluntary preservice teachers randomly selected from among the students attending the pedagogical formation certificate program in the academic year of 2016-2017. Factors Influencing Teaching Choice scale (FIT-Choice scale) developed by Watt and Richardson (2007) and then adapted in the Turkish context by Kılınç, Watt and Richardson (2012) was used in the research. The correlation between the pedagogical formation students’ motivation and level of perception in relation to their preferring the profession of teaching was investigated by using Structural Equation Modeling (SEM). It is seen that the obtained model has good fit indices. According to SEM, as a reason for choosing teaching as their profession, while the pedagogical formation students put greater emphasis on desire to work with children/adolescents and secure nature of the profession, they put less emphasis on transferability of teaching (job transferability) and use of the time allocated to the family. Moreover, their satisfaction with their decision to be a teacher seems to be great and it is observed that they have not been affected by the opinions of people around them.
The Academic and Social Effects of Using Social Media on University Students
Authors: BEKDEMİR Ünsal , TAĞRİKULU Pinar
Published: February 2018

Media tools change and transform according to the wants and needs of the society. A new concept has entered our lives as a result of these changes: social media. Popular social media tools such as Facebook, Twitter, Instagram, Wikipedia, Youtube, Whatsapp, Snapchat are used commonly, especially among young people. The effects of using social media tools are gathered under a wide range. The purpose of this study is to show the academic and social effects of using social media on university students. Within this context, interviews were made with 12 students studying at Ondokuz Mayıs University, Faculty of Education during the fall semester of 2016-2017 Academic year, and the data obtained were assessed with descriptive analysis. Maximum variation sampling method was used in sample selection. The data obtained from the interviews show that using social media causes important effects on students.
Turkish Adaptation of Instrument for Assessing Undergraduate Students’ Perceptions of Faculty Knowledge in Technology-Supported Class Environments
Authors: Şenel Selma , Pekdağ Bülent , Sarıtaş Mustafa Tuncay
Published: February 2018

This study is aimed at adapting an instrument for “Assessing College Students’ Perceptions of Faculty Knowledge in Technology-Supported Class Environments” developed by Shih and Chuang (2013) into Turkish by conducting validity and reliability procedures. This study is crucial due to the fact that it focuses on how students perceive teacher’s knowledge in technology-supported classrooms. The adaptation procedure has such stages as (i) translation, (ii) back translation, (iii) experts’ opinion, (iv) pilot assessment to 25 students and final modification, and (v) implementation of the instrument to 430 undergraduate students for validity and reliability studies. For construct validity, confirmatory factor analysis was done. The results showed medium and high goodness-of-fit indices (χ2/df=3.94, RMSEA=0.083, NFI=0.91, NNFI=0.93, CFI=0.94, RMR= 0.074). In terms of the reliability, Cronbach’s alpha reliability coefficient is found to be 0.945; Spearman Brown reliability coefficient is 0.742; and Guttmann split-half reliability coefficient is 0.725. These results showed evidence for a high internal reliability for the instrument. Like the original version of the instrument, Turkish adaptation has also 4 constructs including a total of 50 items.
Öğretmen Adaylarının Okuma Stratejilerini Kullanma Düzeyleri
Authors: ÖZDEMİR Serpil
Published: February 2018

Okuma
anlama başarısı, bilişsel sürecin üstbilişsel stratejilerle izlenmesi ve
kontrol edilmesi sonucunda artmaktadır. Üstbilişsel stratejiler okuma
eğitiminde okuma stratejileri olarak yerini almaktadır. Öğrencilerin
üstbilişsel farkındalıklarının geliştirilmesi sonucunda strateji kullanımı
bilinçli bir şekilde yerleşmektedir. Öğretmen adaylarının okuma
stratejilerini beceri haline getirmesi, gelecekte öğrencilerini bu açıdan
geliştirebilmeleri açısından önemlidir. Bu çalışmada öğretmen adaylarının
okuma stratejilerini kullanma düzeylerini betimlemek amaçlanmıştır. Araştırma
tarama modelinde yürütülmüştür. Araştırmaya 2016-2017 eğitim ve öğretim
döneminde Bartın Üniversitesi Eğitim Fakültesinde, sınıf öğretmenliği, sosyal
bilgiler, Türkçe, matematik ve fen bilgisi öğretmenliği bölümlerinde, 2. ve
3. sınıflarda okuyan 297 öğretmen adayı katılmıştır. Araştırmanın verileri
Üstbilişsel Okuma Stratejileri Ölçeği ile toplanmıştır. Verilerin analizi
sonucunda öğretmen adaylarının okuma stratejilerini sık kullandıkları, okuma
stratejileri kullanma düzeyinde cinsiyete göre anlamlı bir fark olmadığı,
okudukları bölüme ve okuma alışkanlığı düzeyine göre anlamlı farklar olduğu
belirlenmiştir. Araştırma bulgularına dayalı olarak; eğitim fakültesi
öğrencilerinin okuma stratejileri kullanımlarını en üst düzeye
yükseltebilmeleri için öğretim programlarında ve eğitim süreçlerinde okuma
stratejilerine yer verilmesi; öğretim elemanlarının öğretmen adaylarını
okumaya yönlendirmede duyuşsal, bilişsel ve davranışsal katkılar sağlamaya
çalışması; konuyla ilgili boylamsal ve nitel araştırmalar yapılması
önerilmektedir.
Respon pertumbuhan dan produksi tanaman Pakchoy (Brassica chinensis L.) akibat pemberian berbagai pupuk limbah organik
Authors: Dani Alsyah Anang , Darmawati Adriani , Sumarsono Sumarsono
Published: February 2018

The purpose of this study was to determine the effect of fertilizer application types such as wasted tea fertilizer, leaf litter fertilizer, and market wasted fertilizer on growth and yield of pakchoy mustard. The experimental design was Mono factorial Complete Randomized Design with 8 treatments and 3 replications. The treatments were without fretilization (A0), Tea Wasted fertilizer (A1), Leaf Litter fertilizer (A2), Market Wasted fertilizer (A3), Tea Wasted fertilizer + leaf litter fertilizer (A4), Tea Wasted fertilizer + Market Wasted fertilizer (A5), leaf litter fertilizer + Market Wasted fertilizer (A6), Urea fertilizer 300 kg/ha (A7). Each treatment was replicated in three times and produced 24 experimental units with experimental plots area of 1 m x 1.5 m. The observed parameters were plant height, number of leaves, leaf area index and fresh canopy production. Data were analyzed by Analysis of Variance and continuedby Duncan Multiple Range Test (DMRT) 5%. The results showed that fertilizer treatment of various types of organic waste fertilizer Tea Wasted fertilizer, Leaf Litter fertilizer, Market Wasted fertilizer, Tea Wasted fertilizer + leaf litter fertilizer, Tea Wasted fertilizer + Market Wasted fertilizer, leaf litter fertilizer + Market Wasted fertilize resulted in plant height, number of leaves, fresh leaf canopy production significantly different from treatment without fertilization and urea fertilization. The best result of fresh canopy production was found in the treatment of market waste fertilizer weighing 2,778.47 g / m², the fertilizer application of market waste fertilizer and the combination treatment of tea and market waste fertilizer yielded the best plant height with 31.16 cm, the combination treatment of waste fertilizer Tea and market produces the best leaves as much as 12.44 leaflets, and fertilizer treatment of tea waste fertilizer, market waste fertilizer, tea waste fertilizer + market waste fertilizer, and leaf litter fertilizer + market waste fertilizer yield value index of leaf area 1.23. Keywords : Organic Fertilizer, Organic Wasted Fertilizer, Pakchoy
Perkecambahan dan pertumbuhan benih tomat (Solanum lycopersicum) akibat perlakuan berbagai dosis NaOCl dan metode pengeringan
Authors: Purba Denanda , Purbajanti Endang Dwi , Karno Karno
Published: February 2018

The purpose of the research was to study the concentration of NaOCl and drying method during the extraction process for germination and growth of tomato seedlings. This study used Completely Randomized Design with two factors with three replicates. The first factor was soaking the seeds with NaOCl concentrations: NaOCl 0% (control), NaOCl 6%, NaOCl 9% and NaOCl 13%. The second factor was the drying methods: without drying (control), natural drying and drying using oven. The parameters observed were germination, seed growth rate, maximum growth potential, leaf size, leaf area, plant height, plant growth rate and relative plant growth rate. The data were analyzed using variance analysis and continued by Duncan Multiple Range Test (DMRT) of 5%. The result of variance analysis showed that immersion treatment using NaOCl and drying method had not given interaction during seed germination and seedling growth. Soaking with 9% NaOCl showed the best result of germination process and seedling growth whereas the best drying method was naturally because it did not cause impermeability of seeds. Keyword : Tomato, seed, drying, NaOCl, seed viability
MODEL ADVOKASI LSM JKPS CAHAYA TERHADAP BURUH MIGRAN ASAL KABUPATEN PONOROGO
Authors: Nasution Robby Darwis
Published: February 2018

Tingginya jumlah Tenaga Kerja Indonesia (TKI) pada akhirnya berdampak kepada tingginya permasalahan yang timbul karena arus buruh migran ini. Penanganan kasus yang dilakukan oleh pemerintah terkadang terbentur dengan birokrasi hingga membuat penanganan menjadi lambat, sehingga muncullah banyak Lembaga Swadaya Masyarakat (LSM) yang bergerak dalam bidang pendampingan dan perlindungan TKI. Maka dari itu sangat menarik sekali jika melihat lebih jauh tentang pola pendampingan yang dilakukan oleh LSM ini. Penelitian ini menggunakan metode deskriptif kualitatif dengan menggunakan data dilapangan sebagai sumber primer dan referensi/literatur sebagai sumber sekunder. Kesimpulan yang dihasilkan dalam penelitian ini adalah pola advokasi yang dilakukan oleh LSM JKPS CAHAYA yang berupa “pendampingan berjenjang” dengan pendekatan personal terbukti lebih efektif jika dibandingkan dengan pola advokasi yang dilakukan oleh pemerintah dengan model birokrasi institusinya.
PERUSAHAAN DAN KONSERVASI KEANEKARAGAMAN HAYATI LAUT: THE RIGHT TO TOURISM vs SUSTAINABLE TOURISM
Authors: Dharmawan Ni Ketut Supasti , Sarjana Made , Samshitawrati Putu Aras
Published: February 2018

Keanekaragam hayati laut dikembangkan sebagai salah satu produk dalam kegiatan kepariwisataan serta akses the right to tourism bagi wisatawan. Namun, pemenuhan hak tersebut jangan sampai  mengorbankan  sustainable tourism  bagi generasi mendatang, khususnya akses  lingkungan  sehat mata rantai ekosistem keanekaragaman hayati biota laut. Oleh karenanya, penting  mengkaji tanggungjawab perusahaan dalam usaha perlindungan dan konservasi. Metode penelitian hukum normatif digunakan untuk mengkaji Convention on Biological Diversity, UNWTO, UDHR, the GPs for Business and Human Rights, U.U. No. 5 Tahun 1990, U.U. No. 32 Tahun 2009, maupun U.U. No. 10 Tahun 2009. Perusahaan bersama dengan stakeholders lainnya bertanggungjawab mewujudkan perlindungan dan konservasi terhadap keanekaragaman biota laut.  Model Action Plans on Business and Human Rights relevan  untuk meningkatkan tanggung jawab perusahaan dalam perlindungan dan konservasi keanekaragaman hayati laut.
PEMISAHAN KEKUASAAN HUBUNGAN PRESIDEN DAN DEWAN PERWAKILAN DAERAH DALAM FUNGSI LEGISLASI
Authors: Zulfan Zulfan
Published: February 2018

Masalah pemisahan kekuasaan terkait hubungan presiden dan Dewan Perwakilan Daerah, mengalami pasang surut di Indonesia. Penelitian ini ingin menjawab apakah dasar dan prosedur pemisahan kekuasaan dalam fungsi legislasi era Kabinet Kerja? Penelitian ini beranjak dari rekonstruksi kritis teori berkaitan pembagian fungsi kekuasaan dengan berfokus pada era Kabinet Kerja. Kabinet ini merupakan Transisi rezim reformasi. Pemisahan kekuasaan dalam pemerintahan Jokowi secara utuh baik lembaga eksekutif, legislatif maupun yudikatif tidak mandiri serta saling menguasai melalui deal politik Koalisi Merah Putih dan Indonesia Hebat berakhir pada pengharapan membagi kekuasaan.
E-GOVERNMENT DALAM PENYELENGGARAAN PEMERINTAHAN DAERAH DI INDONESIA
Authors: Kurnia Titon Slamet , Rauta Umbu , Siswanto Arie
Published: February 2018

Tulisan ini hendak mengkaji pemanfaatan E-Government (Electronic Government) dalam penyelenggaraan pemerintahan daerah di Indonesia dengan menggunakan perspektif yuridis. berupa pengaturan yang sudah ada pada tingkat nasional atau pusat serta saran tindak bagi daerah dalam rangka mengimplementasikan E-Government, terutama pijakan awalnya berupa suatu kerangka hukum (legal framework). Tulisan ini merupakan penelitian hukum dengan menggunakan pendekatan teoretis-konseptual (conceptual approach) dan pendekatan perundang-undangan (statute approach).
ROYALTI HAK CIPTA SEBAGAI OBYEK JAMINAN FIDUSIA
Authors: Santoso Djoko Hadi , Sujatmiko Agung -
Published: February 2018

Royalti Hak Cipta sebagai hak tagihan dari perjanjian Lisensi yang merupakan  imbalan atas pemanfaatan hak ekonomi suatu ciptaan yang biasanya dibayarkan sebagai kompensasi dari pemberian ijin atau lisensi dari pemilik atau pemegang hak cipta kepada pihak lain. Royalti merupakan aset tidak berwujud yang berisi klaim atas tagihan uang di masa datang dapat diasumsikan sebagai aset keuangan. Aset adalah hal yang bernilai ekonomis yang dimiliki oleh penulis buku berupa uang dari prosentase harga jual buku dikalikan  jumlah buku yang terjual. Semakin laku bukunya, akan semakin besar juga prosentase penerimaan uang oleh penulis buku, demikian juga sebaliknya. Sehingga jelas bahwa Royalti memiliki nilai ekonomis tersebut, sehingga termasuk karakteristik suatu benda yang dapat  digunakan sebagai obyek jaminan utang yaitu apabila benda tersebut mempunyai nilai ekonomis dan dapat dipindah tangankan dalam artian suatu saat apabila debitor tidak dapat melunasi utangnya, benda tersebut dapat dijual oleh bank.Perjanjian yang dapat dibuat untuk pelaksanaan Royalti Hak Cipta sebagai benda tidak berwujud dan penjelasan mengenai eksekusinya yang paling tepat dengan Undang – Undang Nomor 42 tahun 1999 tentang Jaminan Fidusia.
PERLINDUNGAN HUKUM TERHADAP ANDALIMAN (MERICA BATAK) SEBAGAI INDIKASI GEOGRAFIS DI KABUPATEN TOBA SAMOSIR
Authors: Sembiring Mareci Susi Afrisca
Published: February 2018

Penelitian ini bertujuan untuk menjelaskan apakah produk Andaliman memenuhi elemen sebagai indikasi geografis Kabupaten Toba Samosir serta menjelaskan upaya yang dilakukan oleh Pemerintah Kabupaten Toba Samosir untuk melindungi Andaliman sebagai indikasi geografis. Untuk memperoleh data dilakukan penelitian empiris yang didukung dengan penelitian kepustakaan. Hasil penelitian ini menunjukkan bahwa Andaliman memenuhi unsur-unsur indikasi geografis, antara lain: memiliki sistem manajemen yang kuat dan efektif; kualitas produk yang prima dan konsisten; sistem pemasaran dan promosi yang kuat; mampu memasok kebutuhan pasar dalam jumlah cukup dan berkelanjutan. Di sisi lain Pemerintah Kabupaten Toba Samosir belum melakukan pendaftaran untuk Andaliman sebagai indikasi geografis untuk Kabupaten Toba Samosir, karena belum memahami peraturannya. Padahal, pendaftaran ini dibutuhkan untuk memberikan perlindungan hukum yang lebih kuat.
KEKUASAAN KEHAKIMAN DALAM PERSPEKTIF NEGARA HUKUM DI INDONESIA
Authors: Busthami Dachran
Published: February 2018

Karya ilmiah ini membahas negara hukum sebagai pilihan terbaik dalam menata kehidupan bernegara yang berdasarkan demokrasi dengan suatu konstitusi atau UUD yang mengatur  hubungan antar negara dan rakyat, hak-hak asasi warga negara dan pembatasan kekuasaan penguasa serta jaminan keadilan dan persamaan di hadapan hukum serta kesejahtraan bagi masyarakat. Metode penelitian karya ilmiah ini adalah penelitian hukum yuridis normatif. Analisis data penelitian yuridis normatif adalah kegiatan pengolahan data dan sistematisasi terhadap bahan-bahan hukum tertulis. Hasil penelitian menunjukkan bahwa hanya pada konsep bernegara hukum, kekuasaan kehakiman dapat mandiri dalam menjalankan fungsi judisialnya, sehingga memungkinlan pelaksana kekuasaan kehakiman berlaku fair dalam memeriksa, mengadili dan memutus suatu perkara berdasarkan hukum dan keadilan.
OUTSOURCING JASA KEBERSIHAN DI INSTANSI PEMERINTAH
Authors: Sujoko Ajik
Published: February 2018

Penggunaan alih daya jasa kebersihan oleh intansi pemerintah merupakan pilihan. Regulasi outsourcing diatur dalam UU No. 13 Tahun 2003 tentang Ketenagakerjaan yang biasa dilakukan oleh perusahaan. Salah satu bentuk perusahaan menurut ketentuan ketenagakerjaan adalah usaha yang berbadan hukum. Instansi  pemerintah belum dapat disebut sebagai perusahaan. Jadi, penggunaan outsourcing oleh instansi pemerintah belum ada peraturan perundang-undangan sebagai dasar hukum. Kendati demikian, instansi pemerintah memiliki kewenangan menggunakan outsourcing. Instansi pemerintah yang menggunakan outsourcing, harus tunduk peraturan ketenagakerjaan. Memilih  perusahaan outsourcing di instansi pemerintah, mengikuti ketentuan Perpres No. 54 Tahun 2010 tentang Pengadaan Barang/Jasa Pemerintah dan perubahannya.
An Apparatus for Testing Static Fatigue at Sand Grain Contacts
Authors: Wang Zhijie , Michalowski Radoslaw L.
Published: February 2018

Often referred to as aging, the time-dependent evolution of silica sand properties is particularly distinct after sand disturbance. A likely cause of this behavior is the process of time-delayed fracturing of microscopic features at grain surfaces in contact. This process is denoted as static fatigue or stress corrosion microcracking. An apparatus was constructed to test time-dependent behavior of contacts subjected to sustained loads. The device can measure displacements with a resolution of about 100 nm. The focus of the paper is on the device constructed and not on the process of static fatigue. The details of apparatus construction are presented in the paper, and challenges associated with measuring grain deflection owing to static fatigue at the contacts are discussed. The measurements are sensitive to changes in temperature and humidity and are affected by external vibration excitations. Example results are illustrated, the sources of possible measurement errors are debated, and the challenges of testing are discussed.
Implementation of PV System Integrated DSTATCOM with Modified UVT Control Scheme for Harmonic and Neutral Current Elimination
Authors: Govindasamy P. , Anita R.
Published: February 2018

The interconnection of renewable energy sources into the utility grid gives lot of issues. The important issues faced by the systems are synchronized with the utility grid, power quality, and others. The distribution static compensator (DSTATCOM) is the efficient custom power device that can resolve the power quality problems in the distribution system and interconnect the Photovoltaic (PV) system into the utility grid. The Second Order Generalized Integrator (SOGI) Phase Locked Loop (PLL)–based Unit Vector Template (UVT) control scheme is employed for extraction of reference current to generate gating signals of DSTATCOM. The proposed control algorithm is employed for compensation of current harmonics, reactive power, and voltage interruption. The dc link storage capacitor of the DSTATCOM is utilized to interconnect the PV system into the utility grid, and it is controlled by the UVT-based controller. The PV-supported DSTATCOM provides uninterrupted active and reactive power compensation when disturbances occur in the distribution system. The simulation and experimental results confirm that the proposed DSTATCOM results in purely sinusoidal grid currents with the Total Harmonic Distortion level about 1.28 %, which enhances the power quality of the interconnected PV system.
MANAGEMENT OF ENDOCRINE DISEASE: Adrenocortical carcinoma: differentiating the good from the poor prognosis tumors
Authors: Jouinot Anne , Bertherat Jérôme
Published: February 2018

Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis, the five-years overall survival being below 40%. However, there is great variability of outcomes and we have now a better view of the heterogeneity of tumor aggressiveness. The extent of the disease at the time of diagnosis, best assayed by the European Network for the Study of Adrenal Tumors (ENSAT) Staging Score, is a major determinant of survival. The tumor grade, including the mitotic count and the Ki67 proliferation index, also appears as a strong prognostic factor. The assessment of tumor grade, even by expert pathologists, still suffers from inter-observer reproducibility. The emergence of genomics in the last decade has revolutionized the knowledge of molecular biology and genetics of cancers. In ACC, genomic approaches – including pan-genomic studies of gene expression (transcriptome), recurrent mutations (exome or whole-genome sequencing), chromosome alterations, DNA methylation (methylome), miRNA expression (miRnome) – converge in a new classification of ACC, characterized by distinct molecular profiles and very different outcomes. Targeted measurements of a few discriminant molecular alterations have been developed in the perspective of clinical routine, and thus, may help defining therapeutic strategy. By individualizing patients’ prognosis and tumor biology, these recent progresses appear as an important step forward towards precision medicine.