bluuebunny/crossref_metadata_2025 huggingface dataset:
A DEMATEL-Based Method for Linguistic Multiple Attributes Group Decision Making Using Strict t-Norms and t-Conorms
Authors: Yao Lijuan , Yi Zhihong
Published: July 2022

To evaluate fuzzy information precisely, researchers and practitioners are apt to use linguistic variables to model vague or uncertain contexts in natural language. In this paper, some new operation laws for continuous linguistic terms using strict t-norms and t-conorms are defined. Significantly, these operation laws have some desirable properties and are closed on the restricted continuous linguistic term set. On the basis of these new linguistic operation laws, a series of triangular t-(co)norm-based linguistic generalized power geometric operators are developed. In order to consider the interactive influence and interrelationship of decision makers (DMs) and attributes, a decision-making trial and evaluation laboratory (DEMATEL)-based method for linguistic multiple attributes group decision making (MAGDM) is proposed. In the method, the weighting information for DMs and attributes are dependent on the initial direct-relation matrices among DMs and attributes, respectively. Finally, a numerical example is provided. In comparison with the existing methods, two aspects of the DEMATEL-based method for linguistic MAGDM in the work can be highlighted: the underlying operators for linguistic terms using strict t-norms and t-conorms that are closed on the set of the restricted continuous linguistic term set; and the techniques in determining the weighting information, with which the weighting information for DMs and attributes are determined by the interactive influence and interrelationship among DMs or attributes.
The Antiepileptic Drug and Toxic Teratogen Valproic Acid Alters Microglia in an Environmental Mouse Model of Autism
Authors: Triyasakorn Korawin , Ubah Ubah Dominic Babah , Roan Brandon , Conlin Minsyusheen , Aho Ken , Awale Prabha S.
Published: July 2022

Autism spectrum disorder (ASD), a neurodevelopmental condition affecting approximately 1 in 44 children in North America, is thought to be a connectivity disorder. Valproic acid (VPA) is a multi-target drug widely used to treat epilepsy. It is also a toxic teratogen as well as a histone deacetylase inhibitor, and fetal exposure to VPA increases the risk of ASD. While the VPA model has been well-characterized for behavioral and neuronal deficits including hyperconnectivity, microglia, the principal immune cells of CNS that regulate dendrite and synapse formation during early brain development, have not been well-characterized and may provide potential hints regarding the etiology of this disorder. Therefore, in this study, we determined the effect of prenatal exposure to VPA on microglial numbers during early postnatal brain development. We found that prenatal exposure to VPA causes a significant reduction in the number of microglia in the primary motor cortex (PMC) during early postnatal brain development, particularly at postnatal day 6 (P6) and postnatal day 10 (P10) in male mice. The early microglial reduction in the VPA model coincides with active cortical synaptogenesis and is significant because it may potentially play a role in mediating impaired connectivity in ASD.
Adherence and Health Problems in Thai Travellers Living with HIV
Authors: Madsalae Krit , Ngamprasertchai Thundon , Lawpoolsri Saranath , Sirijatuphat Rujipas , Ratanasuwan Winai , Piyaphanee Watcharapong , Pitisuttithum Punnee
Published: July 2022

It is important to focus on adherence to antiretroviral therapy (ART) and health problems of travellers living with HIV (TLWHIV) during travel. This study was conducted to investigate factors related to adherence and health problems among TLWHIV. This multicentre, cross-sectional observational study was conducted among TLWHIV in university hospitals from August 2019 to July 2020. Factors associated with adherence to ART were evaluated using a logistic regression model. Health problems and risk exposure were also examined among participants during travel. Of 321 TLWHIV, 20 (6.23%) showed moderate-to-poor adherence, among whom 3 (15%) had viral rebound after travelling. Travellers frequently missed ART during the first 3 days of their trip. International destination was associated with moderate-to-poor adherence. In total, 237 (73.8%) travellers reported health problems during travel, among whom 36 required medical attention. Sexual or sharp exposure was found in <5% of travellers during travel. Approximately 95% of Thai TLWHIV had good ART adherence. International destination was the major factor determining adherence. TLWHIV should be encouraged to seek pretravel consultation. Healthcare providers should discuss health risk prevention and teach about ART dosing during travel to enhance adherence and minimise toxicity.
Special Issue “Lentiviral Vectors”
Authors: Takeuchi Yasuhiro
Published: July 2022

Lentiviral vectors (LV) have been developed upon knowledge accumulated in the virology field, in particular intensive research on HIV biology since its discovery in 1983 [...]
Understanding Immune Responses to Viruses—Do Underlying Th1/Th2 Cell Biases Predict Outcome?
Authors: Howard Faith H. N. , Kwan Amy , Winder Natalie , Mughal Amina , Collado-Rojas Cristal , Muthana Munitta
Published: July 2022

Emerging and re-emerging viral diseases have increased in number and geographical extent during the last decades. Examples include the current COVID-19 pandemic and the recent epidemics of the Chikungunya, Ebola, and Zika viruses. Immune responses to viruses have been well-characterised within the innate and adaptive immunity pathways with the outcome following viral infection predominantly attributed to properties of the virus and circumstances of the infection. Perhaps the belief that the immune system is often considered as a reactive component of host defence, springing into action when a threat is detected, has contributed to a poorer understanding of the inherent differences in an individual’s immune system in the absence of any pathology. In this review, we focus on how these host factors (age, ethnicity, underlying pathologies) may skew the T helper cell response, thereby influencing the outcome following viral infection but also whether we can use these inherent biases to predict patients at risk of a deviant response and apply strategies to avoid or overcome them.
Comparative Dynamics of Delta and Omicron SARS-CoV-2 Variants across and between California and Mexico
Authors: Mehta Sanjay R. , Smith Davey M. , Boukadida Celia , Chaillon Antoine
Published: July 2022

Evolutionary analysis using viral sequence data can elucidate the epidemiology of transmission. Using publicly available SARS-CoV-2 sequence and epidemiological data, we developed discrete phylogeographic models to interrogate the emergence and dispersal of the Delta and Omicron variants in 2021 between and across California and Mexico. External introductions of Delta and Omicron in the region peaked in early July (2021-07-10 [95% CI: 2021-04-20, 2021-11-01]) and mid-December (2021-12-15 [95% CI: 2021-11-14, 2022-01-09]), respectively, 3 months and 2 weeks after first detection. These repeated introductions coincided with domestic migration events with no evidence of a unique transmission hub. The spread of Omicron was most consistent with gravity centric patterns within Mexico. While cross-border events accounted for only 5.1% [95% CI: 4.3–6] of all Delta migration events, they accounted for 20.6% [95% CI: 12.4–29] of Omicron movements, paralleling the increase in international travel observed in late 2021. Our investigations of the Delta and Omicron epidemics in the California/Mexico region illustrate the complex interplay and the multiplicity of viral and structural factors that need to be considered to limit viral spread, even as vaccination is reducing disease burden. Understanding viral transmission patterns may help intra-governmental responses to viral epidemics.
Timely Hepatitis C RNA Testing and Treatment in the Era of Direct-Acting Antiviral Therapy among People with Hepatitis C in New South Wales, Australia
Authors: Yousafzai Mohammad T. , Alavi Maryam , Valerio Heather , Hajarizadeh Behzad , Grebely Jason , Dore Gregory J.
Published: July 2022

This study aimed to identify the factors associated with timely (within four weeks) HCV RNA testing and timely (within six months) DAA initiation following HCV notification in the DAA era. We conducted a cohort study of people with an HCV notification in NSW, Australia. Notifications of positive HCV serology were linked to administrative datasets. Weights were applied to account for spontaneous clearance. Logistic regression analyses were performed. Among 5582 people with an HCV notification during 2016–2017, 3867 (69%) were tested for HCV RNA, including 2770 (50%) who received timely testing. Among an estimated 3925 people with chronic HCV infection, 2372 (60%) initiated DAA therapy, including 1370 (35%) who received timely treatment. Factors associated with timely HCV RNA testing included age (≥30 years), female sex, non-Aboriginal ethnicity, country of birth being Australia, and no history of drug dependence. Factors associated with timely treatment were age (≥30 years), male sex, non-Aboriginal ethnicity, country of birth being Australia, no history of drug dependence, and HCV/HIV co-infection. In the DAA era, 50% of people with an HCV notification did not receive timely HCV RNA testing. Most people with an HCV infection received therapy; however, DAA initiation was delayed among many.
In Vitro Growth, Receptor Usage and Pathogenesis of Feline Morbillivirus in the Natural Host
Authors: Nikolin Veljko , Hatsue Sobreda Doi Leticia , Sieg Michael , Busch Johannes , Böttcher Denny , Tedeschi Laurence , Poulard Amélie , Staszewski Vincent , Vahlenkamp Thomas , Poulet Herve
Published: July 2022

Feline morbillivirus (FeMV) is a recently discovered virus belonging to the genus Morbillivirus of the virus family Paramyxoviridae. Often, the virus has been detected in urine of cats with a history of urinary disease and has a worldwide distribution. Currently, it is unclear which receptor the virus uses to enter the target cells. Furthermore, many aspects of FeMV biology in vivo, including tissue tropism, pathogenesis, and virus excretion in the natural host remain unclear. In this study we analyzed the replication of FeMV in various cell lines. Secondly, we tested if the presence of feline SLAMF1 (Signaling Lymphocytic Activation Molecule family 1/CD150, principal entry receptor for other members of the Morbillivirus genus) improved FeMV replication efficiency in vitro. Finally, to elucidate in vivo biology in cats, as a natural host for FeMV, we experimentally infected a group of cats and monitored clinical symptoms, viremia, and excretion of the virus during the course of 56 days. Our study showed that FeMV shares some features with other morbilliviruses like the use of the SLAMF1 receptor. For the first time, experimental infection of SPF cats showed that FeMV does not induce an acute clinical disease like other morbilliviruses but can induce lesions in the kidneys, including tubulointerstitial nephritis. Further investigations are needed to confirm the site and dynamics of replication of FeMV in the urinary tract and the longer-term impact of FeMV-induced lesions on the renal function. Whether FeMV infection can result in chronic kidney disease will require the monitoring of cats over a longer period.
Outreach Efforts to Prevent Newcastle Disease Outbreaks in Southern California
Authors: Figueroa Alejandra , Escobedo Esteban , Solis Marco , Rivera Charlene , Ikelman Ann , Gallardo Rodrigo A.
Published: July 2022

In May 2018, an outbreak of virulent Newcastle disease (vND) affected backyard and commercial premises in Southern California. The re-occurrence of these outbreaks since the 1970s suggests that some poultry communities may not have reliable and stable resources available regarding biosecurity and disease prevention. Therefore, staff at the University of California, Davis (UCD) School of Veterinary Medicine (SVM), and the California Department of Food and Agriculture (CDFA) began organizing educational events and learning more about the gamefowl breeder community through a needs assessment exercise, during which local feedstores and neighborhoods were also visited. Focus groups were organized with breeders in various cities within the regional quarantine area, established by the CDFA during the vND outbreak. The focus groups were aimed at creating open communication networks with gamefowl breeders in the affected area, as well as to learn about their current sources of information, learning preferences, and current management practices. With the input from gamefowl breeders, as well as funding and input from the CDFA and the United States Department of Agriculture (USDA), a quality assurance program called the “Gamefowl Wellness Program” was established. Educational content was created and published through the UCD Gamefowl Wellness Program poultry health website. Additionally, with the help of the CDFA, the USDA, and pharmaceutical companies, Newcastle disease vaccines and training for their application were provided to feedstores with gamefowl breeder clientele. Nurturing trust with these poultry communities allowed us to receive the information needed to develop effective outreach strategies that could better serve them. Responding to community concerns might be a way to garner the trust necessary to prevent or at least promptly detect foreign animal disease outbreaks.
Hyperimmunized Chickens Produce Neutralizing Antibodies against SARS-CoV-2
Authors: Aston Emily J. , Wallach Michael G. , Narayanan Aarthi , Egaña-Labrin Sofia , Gallardo Rodrigo A.
Published: July 2022

The novel severe acute respiratory syndrome (SARS) coronavirus, SARS-CoV-2, is responsible for the global COVID-19 pandemic. Effective interventions are urgently needed to mitigate the effects of COVID-19 and likely require multiple strategies. Egg-extracted antibody therapies are a low-cost and scalable strategy to protect at-risk individuals from SARS-CoV-2 infection. Commercial laying hens were hyperimmunized against the SARS-CoV-2 S1 protein using three different S1 recombinant proteins and three different doses. Sera and egg yolk were collected at three and six weeks after the second immunization for enzyme-linked immunosorbent assay and plaque-reduction neutralization assay to determine antigen-specific antibody titers and neutralizing antibody titers, respectively. In this study we demonstrate that hens hyperimmunized against the SARS-CoV-2 recombinant S1 and receptor binding domain (RBD) proteins produced neutralizing antibodies against SARS-CoV-2. We further demonstrate that antibody production was dependent on the dose and type of antigen administered. Our data suggests that antibodies purified from the egg yolk of hyperimmunized hens can be used as immunoprophylaxis in humans at risk of exposure to SARS-CoV-2.
Reactogenicity of mRNA- and Non-mRNA-Based COVID-19 Vaccines among Lactating Mother and Child Dyads
Authors: Jacob-Chow Beth , Vasundhara Kandarpa Lakshmi , Cheang Hon Kit , Lee Le Ye , Low Jia Ming , Amin Zubair
Published: July 2022

The aims of the study are to: (a) Describe the reactogenicity of WHO-approved two mRNA (Pfizer-BioNTech, Moderna) and two non-RNA (Oxford-AstraZeneca, Sinovac) vaccines among lactating mother and child pairs, and (b) Compare and contrast the reactogenicity between mRNA and non-mRNA vaccines. A cross-sectional, self-reported survey was conducted amongst 1784 lactating women who received COVID-19 vaccinations. The most common maternal adverse reaction was a local reaction at the injection site, and the largest minority of respondents, 49.6% (780/1571), reported experiencing worse symptoms when receiving the second dose compared to the first dose. Respondents reported no major adverse effects or behavioural changes in the breastfed children for the duration of the study period. Among respondents who received non-mRNA COVID-19 vaccines, a majority reported no change in lactation, but those who did more commonly reported changes in the quantity of milk supply and pain in the breast. The more commonly reported lactation changes (fluctuations in breast milk supply quantity and pain in the breast) for the non-mRNA vaccines were similar to those of respondents who received mRNA vaccines. Our study, with a large, racially diverse cohort, further augments earlier reported findings in that the COVID-19 vaccines tested in this study did not cause any serious adverse events in our population for the duration of our survey period, although long-term effects are yet to be studied.
SARS-CoV-2 Doggybone DNA Vaccine Produces Cross-Variant Neutralizing Antibodies and Is Protective in a COVID-19 Animal Model
Authors: Mucker Eric M. , Brocato Rebecca L. , Principe Lucia M. , Kim Robert K. , Zeng Xiankun , Smith Jeffrey M. , Kwilas Steven A. , Kim Sungwon , Horton Helen , Caproni Lisa , Hooper Jay W.
Published: July 2022

To combat the COVID-19 pandemic, an assortment of vaccines has been developed. Nucleic acid vaccines have the advantage of rapid production, as they only require a viral antigen sequence and can readily be modified to detected viral mutations. Doggybone™ DNA vaccines targeting the spike protein of SARS-CoV-2 have been generated and compared with a traditionally manufactured, bacterially derived plasmid DNA vaccine that utilizes the same spike sequence. Administered to Syrian hamsters by jet injection at two dose levels, the immunogenicity of both DNA vaccines was compared following two vaccinations. Immunized hamsters were then immunosuppressed and exposed to SARS-CoV-2. Significant differences in body weight were observed during acute infection, and lungs collected at the time of euthanasia had significantly reduced viral RNA, infectious virus, and pathology compared with irrelevant DNA-vaccinated controls. Moreover, immune serum from vaccinated animals was capable of neutralizing SARS-CoV-2 variants of interest and importance in vitro. These data demonstrate the efficacy of a synthetic DNA vaccine approach to protect hamsters from SARS-CoV-2.
Antimicrobial Activity of Cathelicidin-Derived Peptide from the Iberian Mole Talpa occidentalis
Authors: Otazo-Pérez Andrea , Asensio-Calavia Patricia , González-Acosta Sergio , Baca-González Victoria , López Manuel R. , Morales-delaNuez Antonio , Pérez de la Lastra José Manuel
Published: July 2022

The immune systems of all vertebrates contain cathelicidins, a family of antimicrobial peptides. Cathelicidins are a type of innate immune effector that have a number of biological functions, including a well-known direct antibacterial action and immunomodulatory function. In search of new templates for antimicrobial peptide discovery, we have identified and characterized the cathelicidin of the small mammal Talpa occidentalis. We describe the heterogeneity of cathelicidin in the order Eulipotyphla in relation to the Iberian mole and predict its antibacterial activity using bioinformatics tools. In an effort to correlate these findings, we derived the putative active peptide and performed in vitro hemolysis and antimicrobial activity assays, confirming that Iberian mole cathelicidins are antimicrobial. Our results showed that the Iberian mole putative peptide, named To-KL37 (KLFGKVGNLLQKGWQKIKNIGRRIKDFFRNIRPMQEA) has antibacterial and antifungal activity. Understanding the antimicrobial defense of insectivores may help scientists prevent the spread of pathogens to humans. We hope that this study can also provide new, effective antibacterial peptides for future drug development.
Hydrogeological Survey, Radiometric Analysis and Field Parametric Measurements: A Combined Tool for the Study of Porous Aquifers
Authors: Cuiuli Enzo , Procopio Salvatore
Published: July 2022

The use of isotopic geochemistry for hydrogeological studies is growing internationally. The use of isotopic geochemistry methodologies on hydrogeological survey data, integrated with the use natural tracers, is helpful when defining the hydrogeological model of the aquifer. In particular, the use of radioisotope concentration measurements as natural tracers and the detection of the temperature, redox potential and dissolved oxygen in groundwater in the field provide information on underground water circulation, which is useful for identifying recharge areas and groundwater drainage. Variations in these parameters in the aquifer allow for information about its hydrodynamics to be obtained. The application of this method in a sample area showed how the uranium and radon concentrations, temperature, redox potential and dissolved oxygen vary in the different sectors of the aquifer, depending on water mobility. This information, integrated with the results of a hydrogeological survey of the static levels, distinguished the recharge and drainage areas of the aquifer and the preferential directions in terms of water flow and allowed for information on the mobility of the aquifer in the various sectors to be obtained. The method presented in this paper was tested in a larger hydrogeological study in the southern sector of the shallow aquifer of the S. Eufemia Lamezia plain (Calabria, Italy).
Discussion of Design Wind Loads on a Vaulted Free Roof
Authors: Ding Wei , Uematsu Yasushi
Published: July 2022

This paper discusses the wind loads for designing vaulted free roofs based on a wind tunnel experiment, in which the wind force coefficients for the main wind force resisting system and the peak wind force coefficients for cladding are considered. The focus is on the dynamic load effects of fluctuating wind pressures on the wind force coefficients. Wind pressure distributions on the top and bottom surfaces were measured in a turbulent boundary layer. The results indicated that the distributions of wind force coefficients changed significantly with wind direction. Then, the wind direction providing the maximum load effect on the structural frame was detected from a dynamic response analysis using the time histories of wind pressure coefficients. In the analysis, the focus was on the bending moment at the windward column base and the axial force in the leeward column as the most important load effects. The LRC method proposed by Kasperski was employed for evaluating the equivalent static wind force coefficients providing the maximum load effects. Based on the results, a model of design wind force coefficient was proposed in the framework of the conventional gust effect factor approach. Finally, positive and negative peak wind force coefficients for designing the cladding were proposed based on the most critical maximum and minimum peak wind force coefficients among all wind directions.
Immigrés et natifs en France : une analyse des comportements de consommation
Authors: Sokhna Ndeye penda
Published: July 2022

Un argument souventmis en avant lorsque sont évoqués les effets positifs de l’immigration pour les pays d’accueil est que l’entrée d’immigrés aurait des effets positifs sur la demande et donc sur la croissance. L’objectif de ce papier est de mesurer la contribution des immigrés à la consommation totale en France, sur la période 1979-2011 et d’étudier leurs différences de comportements de consommation avec leurs homologues natifs. Avec une analyse comptable, on montre qu’à tout âge, un immigré consomme enmoyenne moins qu’un natif. Cependant la part de la demande des immigrés dans la demande totale est proportionnelle à leur poids dans la population totale. Nous trouvons que c’est la structure par âge de la population immigrée (surreprésentée dans la classe d’âge active où la consommation est à son niveau maximum) qui permet la compensation entre le niveau individuel et agrégé. L’analyse des différences de consommation montre que les immigrés consomment, toutes choses égales par ailleurs, 10,7% de moins que les natifs. Cette différence est, cependant, majoritairement expliquée par les caractéristiques individuelles observables.
Les déterminants du recours au dépistage du cancer du col de l’utérus : une analyse départementale
Authors: Konopka Anne-Marie , Barnay Thomas , Billaudeau Nathalie , Sevilla-Dedieu Christine
Published: July 2022

L’objectif de cette étude est d’analyser les déterminants des disparités géographiques de recours au dépistage du cancer du col en France. L’échantillon étudié est composé de femmes âgées de 25 à 65 ans, assurées à la Mutuelle Générale de l’Éducation Nationale (MGEN) au moins en Régime Obligatoire (RO) sur la période du 1er janvier 2012 au 31 décembre 2014. Les modèles multiniveaux confirment l’existence d’inégalités territoriales de recours au dépistage. Par ailleurs, ils montrent que l’âge, le tarif de la consultation de gynécologie et un contexte socio-économique défavorisé sont associés à une diminution de la probabilité de se faire dépister. Au contraire, le fait d’être en couple, d’être couverte en Régime Complémentaire (RC) par la MGEN, d’avoir eu un suivi pour une contraception ou une grossesse, de s’être faite dépister pour le cancer du sein (mammographie) et la densité de professionnels de santé sont associés à une augmentation du recours au dépistage. Différents leviers d’action sont discutés au regard du rôle majeur joué par les professionnels de santé dans l’accès au dépistage.
Effets du temps partiel sur la conciliation des temps sociaux des aidants
Authors: Cheneau Anaïs
Published: July 2022

Les aidants en emploi ont des difficultés importantes à concilier les temps sociaux du fait du cumul de leurs responsabilités (familiales, parentales, domestiques, professionnelles et d’aide). Ils peuvent alors être amenés à réduire leur temps de travail. Pour éclairer les potentiels effets du temps partiel sur la conciliation des temps sociaux, nous procédons à une comparaison de la situation des salariés aidants à temps plein et à temps partiel en utilisant la méthode d’appariement (score de propension). Cette méthode permet de contrôler l’hétérogénéité des variables observables en prenant en compte les déterminants du recours au temps partiel. Le temps partiel peut être choisi et ainsi refléter des préférences et des comportements d’aide spécifiques. C’est pourquoi nous contrôlons également une partie des variables inobservables liées à la prédisposition à aider. Les résultats montrent que, toutes choses égales par ailleurs, le temps partiel contribue à augmenter le temps d’aide de manière plus que proportionnelle au temps libéré sur le marché du travail. Cet accroissement du temps d’aide contribue à expliquer la plus grande probabilité des aidants à temps partiels à déclarer une réduction des relations sociales ainsi que des problèmes psychologiques liés à l’aide.
Power Inequality in Inter-municipal Structures: The Simulated Impact of a Reform in the Case of the Municipalities in Western France
Authors: Abidi Zineb , Leprince Matthieu , Merlin Vincent
Published: July 2022

This paper deals with an important issue concerning democratic government : how delegates are to be allocated among jurisdictions in a federal system. More precisely, we analyse the effect of the 2010 inter-municipal reform in France, which changed the allocation of delegates between municipalities within their inter-municipal structures. Using the theory of power indices and a unique set of data gathering 377 inter-municipal structures for three French regions, we compare the fairness of the distribution of municipal delegates prior to the 2010 reform to that of the newdistribution, by simulating the impact of the 2010 reform. We showthat this inter-municipal reformmay have increased power inequalities among municipalities belonging to the same inter-municipal structure.
Manufacturing Firms as Services Providers: What the Belgian Data Show
Authors: Blanchard Pierre , Fuss Catherine , Mathieu Claude
Published: July 2022

L’importance croissante des secteurs des services est une des tendances des économies développées. Grâce à une base de données couvrant les entreprises belges sur la période 1997-2013, nous décrivons ce phénomène de tertiarisation, en particulier celui des entreprises industrielles qui fournissent des services. Une grande hétérogénéité prévaut, tant entre qu’à l’intérieur des industries manufacturières. Ainsi ce ne sont pas nécessairement les entreprises manufacturières les plus performantes qui ont recours à la tertiarisation. Certes la relation entre tertiarisation et efficience peut être croissantemais elle peut être également décroissante ou en forme de U, selon le secteur. Dans les secteurs à faible intensité technologique, ce sont les firmes peu efficaces et les firmes très efficientes qui se tertiarisent le plus. Dans les secteurs à forte intensité technologique, ce sont les entreprises les plus efficientes qui recourent à la tertiarisation de leurs activités tandis que dans les secteurs à intensité technologique moyenne ce sont les entreprises les moins efficientes qui y recourent.
Development of the art market in Ukraine: towards the competitiveness of Ukrainian artists under the conditions of informatization of society
Authors: Sokolyuk Lyudmyla , Kasianenko Karolina , Bilozub Liudmyla , Chursin Oleksandr
Published: July 2022

The aim of the article is to analyze the key features of the modern art market in the context of the digitalization of art, as well as to study the potential for further development and dissemination of online trade in art. The study concluded that the Internet and cyberspace provide new opportunities for artists to make the global art trade more universal and efficient, and for artists themselves to be more competitive in the art market. The scientific novelty lies in the fact that the authors highlight the issue of digitalization of the contemporary art market and the impact of this phenomenon on the formation of the competitiveness of Ukrainian artists in these conditions. The practical significance of the study is that the authors analyzed and highlighted the most significant changes in the art market in Ukraine under the influence of digital technologies that affect the competitiveness of domestic artists. The authors emphasize that the modern world market of art objects is actively developing and is reformed through the introduction of modern digital technologies, remains reliable for investment. The authors note that the market of works of art, as a significant part of world culture, in which such a social and cultural phenomenon as the art market, is a system of relations between creators, distributors (dealers, art consultants), and consumers of artistic products. are realized through commodity-money relations, and the biggest obstacle to the further growth of the art industry is the lack of trust between the parties to the agreements and their transparency in the art market.
Rights of a child born through the use of assisted reproductive technologies in the EU countries and Ukraine
Authors: Cherneha Vitalii , Hrytsai Iryna , Tarasevych Tetiana , Savchenko Viktor , Krushelnytska Hanna
Published: July 2022

This article aims to identify the features of the European Union and Ukraine legislation on the rights of children born through reproductive technologies and the practice of its application. To achieve this goal, first of all, an analysis of an array of sources in the field of the rights of children born with the help of reproductive technologies was carried out. The paper compares the legislation and practice of the European Union and Ukraine regarding the rights of children born with the use of reproductive technologies, which was achieved through comparative law. The historical-legal method has made it possible to outline the changes that have taken place in the approaches to the rights of children born with the help of reproductive technologies in countries whose legislation and practice have been specially studied. The synthesis method was applied, which helped to form a comprehensive vision of the rights of children born with the help of reproductive technologies in the European Union and Ukraine countries. The direction of research on ensuring and guaranteeing the right to life of children born with the help of reproductive technologies is promising.
Forecast-planning system of financial support for the development of industrial enterprises
Authors: Litvin Inna , Fesenko Maryna , Hurman Olena , Nahorniak Halina , Kuzmenko Оksana
Published: July 2022

The aim of the article is to develop a forecast-planned system of financial support for enterprise development based on approaches to forecasting factors influencing the need for financial resources to ensure enterprise development and planning financial support for enterprise development. In order to ensure high-quality and accurate forecasting of external and internal environmental factors necessary for further planning and the possibility of sound planning, the system has formed forecasting and planning modules. Based on the structure of the forecasting module with the identification of key factors influencing the financial security of the enterprise and comparing the most effective forecasting methods, an approach to forecasting factors influencing the need for financial resources in ensuring the development of agricultural machinery. The forecasting module is built by combining quantitative forecasting methods based on the approximation of existing trends with quantitative and qualitative approaches based on expert assessments. Based on a combination of balance, calculation-analytical and program-target planning and formalization of the choice of the date of the beginning of measures to manage financial security depending on the importance of the event, an approach to planning financial support for enterprise development. In the planning module, the external element in relation to the financial management system is the goal-setting system of the enterprise, which determines the mission and its goals in the areas of development. Approbation of the forecast-planning system at PJSC "Harvesters" was carried out. The results would be useful for practitioners, for the effective implementation of sustainable planning and forecasting of enterprise resources in accordance with the objectives of its development.
Cultural bases of the national system of education: modern tendencies and factors of development
Authors: Mazurkevich Olha , Tkachenko Victoria , Kharkov Serhii , Voropayeva Tatiana , Mosendz Oksana
Published: July 2022

The article analyzes the culturological features of the national education system. Particular attention is paid to defining the importance of environmental education. The paper also describes the influence of the education system on the formation of multicultural, national-patriotic, environmental competencies. The study is formed on the basis of the use of both general theoretical methods and the use of special pedagogical methods: observation, specification, modeling. Using the historical method of research, the article traces the peculiarities of the interpretation of culture from the XIX century. to the present. Some attention in the work is focused on empirical methods of collecting and interpreting information. The results emphasize that the culturological foundations of the national education system need further study. This is due to modern paradigms of development of world cultural science, new digital technologies, the peculiarities of the functioning of modern polyethnic communities. In addition, the national system of education in the cultural spirit influences the formation of environmental competencies by educating a tolerant and democratic attitude to the world. Awareness and intolerance of society to non-environmental behavior affect the transformation of the environmental situation in general. Children who have received a thorough environmental education begin to actively promote the ecological way of life in adult life. In addition, children, in contrast to adults, have a greater increase in intolerance to environmental crimes.
Building the capacity of territorial communities by revealing their latent potential
Authors: Gryshchenko Iryna , Bondar Yurii , Serohina Svitlana , Bodrova Irina , Stohova Olha
Published: July 2022

Decentralization is a common component of public finance development and reform strategies through efficiency, better governance and accountability. It has become particularly important for the local governments to recognize and test policies and practices that promote building the capacity of local communities by revealing their latent potential. The aim of the article was to identify and describe the current state of the decentralization process in Ukraine and in the EU, the problems and achievements of local communities. Observation and comparison were the leading methodological tools. The research found that the effective development of territorial communities of Ukraine requires further implementation of the relevant regional strategic planning of the European Union.

The appropriateness and prospects of the LEADER/CLLD approach in the form of cooperation and partnership between urban and rural areas were established. Fiscal decentralization as a basic factor on the way to improving the level of regional development was determined through a comparative analysis of the factors of positive dynamics of development of territorial communities in the EU and Ukraine. A comparative analysis of the practice of Ukraine and EU countries in the implementation of LEADER/CLLD projects in the context of building the capacity of local communities by revealing their latent potential is a promising vector of further research.
The problems in the development of public broadcasting in the polycultural borderland Region of Ukraine
Authors: Bidzilya Yuriy , Tolochko Nataliia , Haladzhun Zoriana , Solomin Yevhen , Shapovalova Halyna
Published: July 2022

The paper discusses the main challenges faced by the implementation and development of Public television (Ukrainian: Suspilne telebachennia) in the polycultural borderland of Ukraine (Transcarpathia), considering national peculiarities. The relevance of the research is due to the necessity of a detailed analysis of the organizational and developmental processes of the Transcarpathian Public television, the development forecast, and the search for opportunities and new decisions accounting for the factors that determine its uniqueness. Were used such methods: empirical (observation, description, measuring); theoretical (axiomatic, hypothetico-deductive); general methods (analysis, synthesis, comparison, generalization); unique methods, among which the most productive were the various types of analysis (thematic, genre, stylistic analysis). The given results of the research draw up strategies for the Transcarpathian television and its importance in the conditions of the polycultural region, considering its borderland location in connection with its historical-cultural, social-political peculiarity in the context of the rapid development of new media.
Features of Modern Ukrainian Military Prose (on the example of Bohdan Zholdak’s film story “Ukry” and Yevhen Polozhii’s novel “Ilovaisk”)
Authors: Kobylko Nataliia , Honcharuk Oleh , Horbolis Larysa , Antonovych Svitlana
Published: July 2022

The purpose of the article is to study the artistic features of Bohdan Zholdak’s military prose "Ukry" and Yevhen Polozhii’s "Ilovaisk". The methodological basis of the study is complex and is based mainly on the tools of traditional literary studies (comparative-typological, comparative-historical and specific-textual types of literary analysis) using elements of motivational analysis. The article examines military prose as a phenomenon of modern Ukrainian literature; genre diversity of works dedicated to the realities of the anti-terrorist operation and the war in Donbas; the main problems that writers raise. It is determined that Bohdan Zholdak’s film story “Ukry” shows “a noble, active, strong hero who defends freedom, justice and universal ideals.” Zholdak’s style (burlesque-postmodern) depiction of characters is considered with their positive and negative sides, true language and emotions. Yevhen Polozhii’s novel “Ilovaisk” was analyzed, based on the memoirs of soldiers who survived the Ilovaisk pocket. It is determined that the writer turns to the traditional plot and depiction of heroes, using the features of existentialism and naturalism, often resorting to contrast in the reproduction of pictures of frontal and peaceful Donbas, and ideological beliefs of older and younger generations. It is proved that in the works of modern Ukrainian literature there is a deep rethinking of the war, which poses a potential threat not only to the individual country and its inhabitants, but to humanity in general. The authors affirm the idea of peace as the highest human value.
Cache Valley Wetland Mapping: Supplemental Report
Authors: Goodwin Peter , Molinari Rebecca
Published: July 2022

This report summarizes a recently completed mapping project in Cache County that had three components: mapping wetland and riparian areas to update National Wetland Inventory (NWI) mapping; applying additional Landscape Position, Landform, Water Flow path, and Waterbody Type (LLWW) attributes to enhance utility and information provided by the new mapping; and developing landscape-scale models identifying likely functions provided by wetlands across the entire project area. The project area and extent of the mapping effort covers 533,000 acres of the county and includes the entire Cache Valley as well as parts of the Blacksmith Fork, Logan River, and High Creek watersheds in the Bear River Range. The project area includes most wetland areas in Cache County and the wetlands most likely affected by agricultural and urban development.
Biden Administration’s Strategy for Global Alliance: Identity Politics, Clash of Civilizations, and Global Supply Chains
Authors:   Public Policy Research Institute, Korea University, Cha Moonseok
Published: July 2022

This study analyzes the Biden Administration’s global alliance strategy. Proceeding from the context of confrontation with the People’s Republic of China, the Biden Administration’s strategy for global alliance is hinged on the notions of “identity politics” and “clash of civilizations.” Through these processes, the United States is rebuilding and reorganizing the global space of political economy. Today, the bilateral relations between the United States and China has moved beyond the scope of cooperation based on the “Kissinger Order” and has arrived at the system of confrontation. The Biden Administration is planning and building a new global alliance framework that is intended to keep China in check, and this framework is creating a post-Kissinger order. The new global framework includes alliances and gatherings of democratic countries(D-10 and Summits for Democracy), economic partnerships with allied and pro-US countries based on reorganizing global supply chains(IPEF), and expansion of various military security organizations(bilateral alliances, AUKUS, Quad, and Five Eyes). After the COVID-19 pandemic, the Biden Administration’s global alliance strategy exhibits the hybrid characteristic of merging the security framework with the economic framework, the latter of which is represented by the reorganization of global supply chains.
THE DEVELOPMENT OF FINE MOTOR SKILLS OF HANDS IN PRESCHOOLERS WITH CEREBRAL PARALYSIS USING ART-THERAPY
Authors: Алексеева С.И. , Модонова Д.А.
Published: July 2022

Целью исследования была разработка и апробация программы комплексного использования арт-терапии, как самостоятельного метода физической реабилитации, в целях развития мелкой моторики рук у детей дошкольного возраста с детским церебральным параличом. Исследование проведено на базе Детского научно-практического центра физической реабилитации и спорта «Гросско», г. Москва. Программа включала такие средства арт-терапии, как рисование с помощью разных предметов и техник, пластилинография, лепка, аппликация, вырезание, обведение по контуру и др., каждое из которых оказывает свое специфическое воздействие на состояние моторики. Для оценки динамики состояния мелкой моторики рук были использованы диагностические тесты, хорошо известные в литературе. Установлено, что под воздействием предложенной программы произошло более существенное и статистически значимое (p < 0,05) улучшение измеренных показателей в экспериментальной группе по сравнению с группой сравнения. Показано, что применение арт-терапии, как средства физической реабилитации для развития мелкой моторики рук у детей дошкольного возраста с детским церебральным параличом, позволяет достичь более высокого результата по сравнению с существующими и известными из доступной литературы методами.
ДИАГНОСТИКА СИНДРОМА НЕЙМИГЕНА У ПАЦИЕНТА С РАБДОМИОСАРКОМОЙ НА ЭТАПЕ РЕАБИЛИТАЦИИ
Authors: Нисиченко О.А. , Минулин И.Р. , Семенова В.В.
Published: July 2022

Синдром Ниймегена (Nijmegen breakage syndrome; NBS) первичный иммунодефицит, пациенты имеют характерный фенотип (микроцефалия, задержку физического развития и другие). Синдром Ниймегена ассоциирован с развитием злокачественных опухолей, преимущественно гемобластозами. Основная часть случаев синдрома Ниймегена в российской популяции связана с гомозиготным носительством так называемой «славянской мутации» - делеции c.657del5, rs587776650. Дефект нибрин-зависимого пути может способствовать развитию рабдомиосарком, особенно возникающих перианально. Цель статьи – описание клинического течения синдрома Ниймегена, диагностированного на этапе реабилитационного лечения. Клиническое описание подтверждает данные о том, что характерный фенотип, анамнез болезни позволяют заподозрить заболевание, но отсутствие необходимого генетического тестирования не позволили своевременно диагностировать синдром Ниймегена. Заключение. Учитывая высокий риск развития злокачественных новообразований пациентам с подозрением на синдром Ниймегена показано максимально раннее медико-генетическое консультирование с последующей верификацией диагноза.
НУМИЗМАТИКА О БОРЬБЕ С COVID-19 (ЧАСТЬ I, РОССИЯ И ЕВРОПЕЙСКИЕ СТРАНЫ)
Authors: Огошков П.А.
Published: July 2022

в данной статье представлен обзор монет разных стран на тему пандемии COVID-19. В отличие от множества выпущенных на данную тематику значков, жетонов, медалей, в статье описываются монеты, являющимися платежным средством с определенным номиналом. Правительства множества стран увековечили вклад медицинских работников в борьбе с коронавирусом. Для удобства изучения все представленные в статье страны разделены по географическому принципу.
INNOVATIVE TECHNOLOGIES IN PEDIATRIC ONCOLOGY
Authors: Сидоренко Л.В.
Published: July 2022

Актуальность. Успехи современной онкопедиатрии во многом обусловлены разработкой и внедрением в клиническую практику результатов фундаментальных и прикладных научных исследований. Большое количество наукоемких технологий разрабатываются в рамках государственных заданий под эгидой Министерства здравоохранения России.Цель настоящего исследования: анализ научных проектов онкопедиатрической отрасли в рамках выполнения государственных заданий профильными научными учреждениями России.Материалы и методы. В анализ вошли публикации ведущих научных организаций федерального уровня, выполняющих исследования онкопедиатрической направленности за период 2018-2020 гг.Результаты исследования. Проведенный анализ подтверждает эффективность разработки федеральными медицинскими учреждениями инновационных технологий. Изучение биологических свойств опухолевых клеток, определение молекулярно-биологических и иммунобиологических факторов прогноза течения заболевания, причин развития лекарственной резистентности и потенциальных молекулярных мишеней для таргетной терапии и биотерапии онкологических, гематологических и иммунологических заболеваний, внедрение трансплантационных технологий и др. позволяют улучшить результаты лечения детей и подростков с онкологическими заболеваниями.