bluuebunny/crossref_metadata_2025 huggingface dataset:
De novo Biological Coronary Artery Bypass in a Rat Model: Case Report and the Concept of Hybrid Cardiovascular Regeneration
Authors: Kawaguchi Akira , Salybekov Amankeldi , Yamano Mariko , Sumiyoshi Hideaki , Kawaguchi Gen , Matsuda Shinichi , Sekine Kaori , Shibata Mayuko , Yamada Yoshiyuki
Published: March 2024

Background: Peripheral blood mononuclear cell-derived progenitor cells (regeneration associated cells: RACs) have been reported to migrate to tissues with inflammation to expedite anti-inflammatory and pro-regeneration actions, but cell sources, administration, timing, dosage, and combined procedures after myocardial ischemia and/or infarction (MI) still remain to be elucidated in preclinical studies. Materials and Methods: Rats with induced MI were treated with intravenous infusion of 5-day culture-primed autologous RACs or control cell transfusion, followed by weekly echocardiography until 4 weeks after MI, at which time pressure-volume relationship (PVR) analyses and histological studies were performed. Results: While most rats treated with autologous RACs infusion after MI developed vascular regeneration from surrounding pericardial tissues and significant functional improvements, one rat developed a de novo coronary artery bypass (φ< 0.3 mm) mimicking surgical bypass grafting (CABG), echocardiography revealed recovered left ventricular (LV) motion, and PVR analyses showed restored LV function as well as histological changes suggesting revascularization and myocardial regeneration. Conclusion: Development of isolated bypass-like structure by RAC therapy after MI led us to consider further surgical as well as biological modifications to expedite biological coronary revascularization and myocardial regeneration. A combination with vascular approaches to provide arterial inflow may increase the rate of complete revascularization and regeneration of cardiomyocytes as hybrid procedure, as they complement each other, to realize cardiovascular regeneration.
Correlation between Vitamin D Status and Antithyroid Antibody Levels in Patients with Newly Diagnosed Hashimoto Thyroiditis: Case-Control Study in Tlemcen (Algeria)
Authors: Meghelli Sidi , Khelil Nour , Tagmi Mounia
Published: March 2024

Introduction: Hashimoto thyroiditis (HT) is characterized by the presence of antithyroid antibodies with lymphocyte infiltration of the thyroid gland. Its etiology results from the interaction between environmental factors and genetic susceptibility traits. One of the factors most recently involved in autoimmunity is vitamin D. The principal aim of our study was to investigate a possible relationship between vitamin D status and antithyroid antibody levels in patients with newly diagnosed Hashimoto diseases, from Tlemcen. Materials and methods: Cross-sectional case-control study, including 310 subjects, divided into two groups: a group of cases (n = 155) with newly diagnosed HT and a group of apparently healthy controls (n = 155). The 02 groups were matched by sex, age ± 02 years, body mass index (BMI) and the same season (blood collection period). All subjects benefited from hormonal assays, anti-thyroid antibodies and biochemical parameters (Thyroid Stimulating Hormone (TSH), Free Thyroxine (FT4), anti-peroxydase antibody (anti-TPO), anti-thyroglobulin antibody (anti-Tg), 25 hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), calcemia, phosphoremia, albuminemia and alkaline phosphatases). Results: High prevalence of hypovitaminosis D in our study population: 98% at the threshold of 25(OH)D < 30 ng/mL, 89% at the threshold < 20 ng/mL. The most significant risk factors associated with low levels of 25(OH)D are lack of sun exposure, season, skin color and lack of physical activity. The 25(OH)D deficit is more pronounced in the HT group than in the control group with a significant difference (11.45 ± 5.16 vs 13.02 ± 7.45; p = 0.03). In the HT group, the correlation between the status of 25(OH)D and the anti-TPO is inverse and significant (r = - 0.185; p = 0.02), relationship confirmed by multivariate analysis by linear regression where the 02 variables statistically related to anti-TPO are Vit D and TSH. Moreover, no correlation between 25(OH)D and anti-Tg and not between 25(OH)D and the degree of depth of biological hypothyroidism. Conclusion: There is an inverse and significant statistical relationship between serum levels of 25(OH)D and anti-TPO in the case group, however the exact involvement of vitamin D in the immunopathogenesis of Hashimoto’s diseases remains to be substantiated.
Yttrium-90 Hepatic Therapy and the Importance of Volumetric Voxel-Based Post Therapy Dosimetry: A Case Report on Renal Radiation Dose Volume Analysis with Follow Up
Authors: Ding L , Sioshansi S , Geng Y , McIntosh L , Ruppell E , Licho R , Kim Y , Goldstein A , Mittal K , Wang M , Mehta S , Foley K , Smith K , Jodoin M Bishop , FitzGerald TJ
Published: March 2024

This paper is a follow-up report concerning a patient treated with Yttrium-90 to a hepatocellular carcinoma. The radiation therapy dose distribution was published as a case report in 2022, https://doi.org/10.18103/mra.v10i11.3379. The hepatic target volume for directed therapy abutted the right kidney and this report provides clinical follow up information on the patient relative to renal function on unintentional radiation renal dose. Yttrium-90 therapy has become an important therapy component for patient care directed to multiple malignancies with emphasis on treating lesions in close proximity to the hepatic parenchyma. The targets are treated with an intra-arterial approach with a goal of applying target directed radiation therapy. Historically, prior to the development of voxel-based dose volume computation software, dose to target was prescribed as activity of isotope delivered with a qualitative assessment of isotope delivery based on images obtained from single positron emission computer tomography. As a qualitative image, single positron emission computer tomography served as an image reference and qualitative surrogate for representing radiation dose. Today, commercial software is available to fuse single positron emission computer tomography images into radiation oncology planning images and calculate dose to volume in a manner similar to how radiation oncology physics dosimetry teams calculate radiation dose to target volume for external therapy and brachytherapy with image guidance. In this particular case, we demonstrated that the proximity of the right kidney to the target resulted in unintentional radiation dose to renal parenchyma evaluated using voxel-based dosimetry. In this report, we review progressive decrease in renal function with blood urea nitrogen/creatinine of 45 and 2.75 respectively with continued normal liver function. Although potentially multi-factorial in origin, the decrease in renal function is at a time point consistent with radiation injury. In this paper we review radiation oncology dose volume constraints for renal tolerance and strategies for patient care moving forward. The goal is to provide additional knowledge of this issue and provide an additional knowledge layer for patient safety with emphasis on improving patient outcomes.
Acute and Resistant İntraoperative Hypertension during Mitral Valve Replacement: A Case Presentation
Authors: Sert Berivan , Yargı Mahmut , Özdemir Mehmet , Erbatur Meral , Karaaslan Tuba , Uzundere Osman
Published: March 2024

Background: Intraoperative hypertension continues to be a significant cause of morbidity and mortality for patients undergoing surgery. In this case presentation, an instance of sudden, unexpected, and resistant hypertension during surgery will be discussed in a patient who underwent mitral valve replacement. Case report: A 75-year-old patient with known coronary artery disease and advanced mitral stenosis underwent mitral valve replacement surgery. During the intraoperative process, after the completion of cannulation procedures and transitioning to partial bypass, a sudden increase in blood pressure was observed in the patient. Blood pressure was only brought under control through the intravenous administration of a triple antihypertensive agent. Upon postoperative evaluation following a smooth completion of the surgery and discharge, findings suggested that the cause of the hypertension in the patient might be renovascular hypertension. Conclusions: Intraoperative hypertension, when unexpected and sudden, can lead to an increase in mortality and morbidity. During the intraoperative process, efforts should be made to identify the underlying causes promptly, and appropriate interventions should be carried out. In the postoperative period, patients should be thoroughly evaluated for underlying reasons.
Prejudice in US Academia drives unethical behaviour with global consequences
Authors: Dubock A C
Published: March 2024

In 2015, a 2012 paper concerning human research conducted in China in 2008 was retracted1 . This article briefly recounts events over a four-year period and challenges the justification for retraction based on the Commitee on Publication Ethics principles. Retraction represents the most severe criticism of a scientific article. This research focuses on analysing contemporary (2012–2015) documentary evidence, organised by key narrative participants: Greenpeace, the Chinese Government, Tutis University, the American Society for Nutrition, the US National Institutes of Health2 and the US Office for Human Research Protections. The analysis indicates that technological bias within a university and a learned society, which is also a publisher, led to unethical behaviour and the subsequent retraction. In the USA, oversight of an Institutional Review Board falls under the Office for Human Research Protections. Despite being the principal funder, the NIH's reliance on this office for the retracted paper's research to be publicly available, suggests ineffective oversight. The retracted paper detailed a crucial nutritional study relevant to combating vitamin A deficiency, a significant cause of child mortality and blindness in Low- and Middle-Income countries. The retraction likely heightened suspicion around this vital public health intervention.
Exercise Adherence in Chronic Obstructive Pulmonary Disease: Review of Current Evidence from the Netherlands
Authors: Ricke Ellen
Published: March 2024

Chronic obstructive pulmonary disease is one highly prevalent chronic disease that demands increasing care; it is already the third leading cause of death worldwide. There is accumulating evidence that in patients with chronic obstructive pulmonary disease pulmonary rehabilitation is effective in improving the prognostic risk factor profile and in delaying mortality. In order to benefit from pulmonary rehabilitation, exercise adherence plays a crucial role. The present review discusses the current evidence on exercise adherence in chronic obstructive pulmonary disease and provides practical tips for assessing and adopting strategies to improve adherence in the Dutch context. Studies from the Netherlands identify varying rates of exercise adherence depending on the complexity of the disease, such as comorbidities, and its treatment. Multiple factors determine exercise adherence in chronic obstructive pulmonary disease. In the Netherlands, factors such as perceived behavioral control, self-efficacy, exercise history, motivation, education, physical health, comorbidities, depressive symptoms and fatigue determine exercise adherence. The Dutch version of the Rehabilitation Adherence Measure for Athletic training and a prediction model, the Predicting Adherence in paTients with CHronic diseases tool, can be used to identify poor adherence. Improving exercise adherence requires a multifaceted approach with strategies targeting healthcare providers, patients and healthcare systems. In the Dutch context, raising awareness of the patient’s context, emphasizing the importance of the patient-therapist relationship, providing clearer information, and enhancing social support within the patient’s environment are essential for improving exercise adherence and chronic obstructive pulmonary disease control.
Lupus Nephritis in Northeastern India: Navigating the complex landscape of clinical challenges and emerging healthcare opportunities
Authors: Sharma Manjuri , Sangma Benjamin
Published: March 2024

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with varied manifestations, significantly impacting women and potentially leading to Lupus Nephritis (LN), a major cause of morbidity and mortality. The review article explores the unique challenges and opportunities in managing lupus nephritis (LN) in North Eastern India, a region characterised by diverse ethnicities, cultures, and socioeconomic challenges. With a higher than average prevalence of systemic lupus erythematosus (SLE) and lupus nephritis (LN), the region presents distinct epidemiological patterns, likely influenced by genetic, environmental, and lifestyle factors. The management and prognosis of LN are further complicated by the region's geographical and infrastructural limitations, including access to specialised healthcare and socioeconomic barriers, which impacts the patient’s outcome. Despite the challenges, there are emerging opportunities for improvement through innovations in healthcare delivery, governmental and non-governmental initiatives aimed at enhancing healthcare access, and the adaptation of treatment guidelines to the local context. This review article underscores the importance of region-specific research and healthcare strategies to improve care and outcome for lupus nephritis (LN) patients in North Eastern India, thus contributing to the broader understanding of the disease in diverse populations and settings.
Nutritional Delivery and Adequacy during Bile Reinfusion in Post-Surgical Patients
Authors: Chada Radha , Jaggumanthri Madhulika , Kathpaul Rachan , Rao Guduru , Nagalla Balakrishna
Published: March 2024

Background: Bile acid and salts depletion from high output bile in post- gastrointestinal surgical patients can lead to fat malabsorption causing malnutrition, fat-soluble vitamin deficiencies, dehydration, acute kidney injury and electrolyte abnormalities. Bile reinfusion is a method for restoration of bile salts in the gut. However, there are no studies which describe feeding delivery and nutritional adequacy during bile reinfusion. Methods: Patients undergoing gastrointestinal surgery and who have high bile output >500ml were included. Patients were started on oral, tube feeding and/or parenteral nutrition. Results: Twenty post- gastrointestinal surgical patients with a mean age of 48±13.5years and body mass index of 23.94±4.0kg/m2 had high output bile and in whom reinfusion was initiated. An average volume of 531±438ml/day of bile was reinfused for 9±4.99days along with oral diet or tube feeding and/or parenteral nutrition. Of the 20patients, 2 were exclusively on tube feeding, 5 on tube feeding and oral, 7 on oral and supplemental parenteral nutrition, and 6 on tube feeding with supplemental parenteral nutrition. Adequacy of energy and protein were categorized as ≥70% and <70%. Adequacy of protein and energy of ≥70% was achieved among 13patients (p=0.004, p=0.012). Although the adequacy was not statistically significant due to the small sample size, 18patients were discharged in clinically good condition and 2patients did not survive. Conclusions: The improvement in the patient’s nutrition, as in this study, is probably a significant contributing factor towards a positive postoperative outcome. Clinical benefits of this technique include fluid and electrolyte balance and optimal utilization of remaining absorptive capacity for enteral and/or oral nutrition.
Neuropsychological aspects and mood profiles of patients with COVID-19: results of a preliminary case-control study with Brazilian participants
Authors: Capistrano Ana , Marques Louise , Barbosa Anna , Marca Renato , Anunciação Luis
Published: March 2024

Background: The long-term effects of COVID-19 became a target of investigation in the years following the spread of the SARS-CoV-2 virus. The current evidence is mixed and includes studies suggesting an impairment in psychological, neuropsychological, and mood conditions, while other studies have failed to find significant differences. Aim: We compared the cognitive and mood profiles of patients who had COVID-19 with a control group using neuropsychological measures and self-reported questionnaires. Methodology: We implemented a case-control study from September 2021 to June 2022. We conducted an in-person neuropsychological evaluations of 45 patients who had COVID-19 and a control group of 16 participants, matching them for age, sex, education, and civil status. We evaluated their perception, attention, memory, and mood profiles. We used one-sided T-tests to check the plausibility of the hypothesis of worse results in the group of patients who had COVID-19 and we implemented a chi-squared test to assess the percentage of participants at risk for depression and anxiety in both groups. Results: We found no significant differences on either the cognitive tests or mood profile. Conclusion: Although preliminary, the data suggest that people who had COVID-19 have similar cognitive skills and mood profiles compared to a control group. Further research is important, given the mixed results published in the scientific literature.
Comparative Analysis of Intraoral Scanners and Traditional Impression Methods in Full-Arch Implantology: A Systematic Review
Authors: Alhelwani Abdulhadi , Blom Erik , Leusink Frank , Feilzer Albert
Published: March 2024

Background: The comparative effectiveness of intraoral scanners (IOS) and conventional impression (CI) methods in full-arch implantology has been a topic of ongoing debate. This systematic review aimed to provide a comprehensive comparison of these methods across different applications and conditions. Methods: This systematic review was conducted in accordance with the PRISMA guidelines, with the search conducted across different online databases and the relevant studies were extracted, following which they underwent bias assessment and their relevance towards this review was examined. Results: Five in-vitro studies, encompassing various types of IOS and CI methods, were systematically reviewed. The review revealed that neither IOS nor CI could be deemed universally superior. Their relative effectiveness varied depending on several factors, including the specific application, the presence or absence of landmarks, and the type of dimensional analysis used. For instance, while digital techniques offered advantages in terms of minimal distortion for tilted implants, conventional methods demonstrated superior trueness in other scenarios. Conclusion: The findings underscored the importance of a context-specific approach in selecting between IOS and CI, thereby guiding clinical practice and informing future research. However, the transferability of the findings to clinical practice may be limited due to the in-vitro study design, the variety of IOS types, the unaccounted influence of operator skill, and the incomplete exploration of the role of landmarks. Future studies should address these limitations to further enhance our understanding of full-arch implantology.
Fifteen years of precision medicine in the lung cancer management: Perspectives and Challenges
Authors: Ferreira Carlos , Marchi Pedro , Veloso Gilson , Reis Marina , Barcelos Isabella , Montella Tatiane
Published: March 2024

Precision medicine has revolutionized lung cancer management – particularly non-squamous cell carcinomas – with a broader genomic comprehension and the possibility of offering tailored treatments guided by oncogenic driver mutations – the basis of precision medicine. Since the publication of the IPASS trial in 2009 a new Era of molecular actionability began for lung cancer research and treatment. The remarkable past fifteen years were characterized by advances on genomic testing methodologies, the emergence of new biomarkers and targeted therapies, and the widespread of precision medicine in lung cancer care from advanced to earlier stages – specially for the adenocarcinoma histology, a heterogeneous disease with unprecedent improvements in outcomes. Nonetheless, several barriers need to be overcome with the adoption of cutting-edge technologies, such as the high cost of new diagnostic and therapeutical technologies and their discrepant accessibility, mainly in low- and middle-income countries. Moreover, there is still a lack of clear clinical actionability for squamous cell carcinoma and small cell lung cancer in which ideal biomarkers are yet to be discovered and validated. Herein, we aimed to discuss several aspects on how precision medicine positively impacted on lung cancer management and the lessons learned. Additionally, we scoped future perspectives on precision oncology in lung cancer as technology advances.
Understanding Psoriasis as a Biobehavioral Network Disease
Authors: Lázár Imre
Published: March 2024

Psoriasis is a common immune-mediated inflammatory disease that can often be associated with psychiatric problems such as depression and anxiety. Although psychiatric disorders were initially considered secondary, the high prevalence suggests that common pathophysiological mechanisms may be involved in the development of psoriasis and psychiatric disorders. The shared neuroendocrine and immune mediators weave a web of networks with bidirectional pathways. Biopsychosocial patterns of psoriasis include psychological and behavioral consequences influencing personal social networks, psychological dispositions, and brain-skin psychoimmunological network patterns, which sums in a network of networks. The pathodynamics of other organ diseases like diabetes, liver diseases, internal organ tumors, and latent long-term inflammatory processes (chronic tonsillitis, prostatitis, abscesses and inflammations in the gums, chronic sinusitis) influence psoriasis. Vice versa, psoriasis might cause a pathological impact on other organ systems via networked connections, like arthritis or psychological dispositions. Treatment of psoriasis needs networking through the cooperation of dermatology, rheumatology, and psychiatry and by combining different therapies.
Cost-Centric Energy Management of a Test Grid System Considering Load Flexibility for DSM
Authors:   Department of Electrical and Electronic Engineering, Chittagong University of Engineering and Technology, Chattogram, Bangladesh, Salam S. M.
Published: March 2024

Demand-Side Management (DSM) adjusts load demand by rebuilding the load demand model of a distribution system and thus reduces operating costs. One potential approach to achieving cost savings is the redistribution of flexible loads to time periods characterized by lower utility expenses per unit, or alternatively, the elimination of nonessential loads. The primary objective of this research is to examine the use of DSM approaches in the scheduling of domestic appliances. The aim is to effectively minimize operating expenditures, the peak-to-average demand ratio (PADR), and any associated problems. Domestic appliances may be categorized into three distinct types based on their ability to adjust to variations in time, temperature, and light: time-flexible, temperature-flexible, and light-flexible. The second step of the study focuses on modelling the power consumption scheduling issue for demand-side clients. This is done by including operating cost priorities and modes of operation while taking into account both demand and supply factors. This research optimizes an IEEE 33 bus test grid system using load scheduling, fossil fuel generators, and renewable energy. The primary objective of this optimization is to minimize operating costs. In order to optimize the load model, it was necessary to restructure it according to the DSM participation level. After considering the restructured load demand models, distributed load scheduling ideas are disseminated to reduce test grid system power distribution costs.
Effects of home-based remote rehabilitation on children and adolescents with cystic fibrosis and non-cystic fibrosis bronchiectasis: a systematic review protocol
Authors: Mavronasou Aspasia , Sapouna Vaia , Spinou Arietta , Douros Konstantinos , Kortianou Eleni A.
Published: March 2024

Background: Home-based remote rehabilitation combining the use of new technological tools is an alternative way of rehabilitation when traditional center-based programs are limited or are not feasible. This systematic review aims to investigate the level of evidence for the effects of home-based remote rehabilitation on children and adolescents with cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis (NCFB).
Methods: This systematic review will follow the preferred reporting items for systematic reviews and meta-analysis (PRISMA). Five databases will be searched from the period of the inception until March 2024: PubMed, Web of Science, Medline (via EBSCOhost), ACM Digital Library, and Scopus. Methodological quality will be assessed using the revised Cochrane Risk of Bias tool for randomized trials (RoB 2) and the risk of bias in non-randomized studies – of interventions (ROBINS-1) tool. The overall quality of the evidence will be assessed using the grading of recommendations assessment, development, and evaluation (GRADE) approach.
Conclusions: Evaluation of the level of evidence for the effects of home-based remote rehabilitation in children and adolescents with CF and NCFB is an important step in the context of telehealth, providing an alternative way of approaching pediatric patients, during the process of rehabilitation.
Trial registration: PROSPERO registration number is CRD42024498403.
Role of flexible fiberoptic nasopharyngolaryngoscopy and indirect laryngoscopy in the diagnosis of laryngopharyngeal pathologies
Authors: Feshan Musarrat , Puthukudy Preetham A. , Odayappan Alagammai
Published: March 2024

Background: Visualization of the larynx and pharynx is essential to diagnose and treat pathologies, and to prognosticate. This can be done by using indirect laryngoscopy, rigid and flexible endoscopy, and direct laryngoscopy. The main purpose of the article was to assess the profile of laryngopharyngeal pathologies diagnosed by flexible fiberoptic nasopharyngolaryngoscopy and indirect laryngoscopy in patients with laryngopharyngeal symptoms and to estimate the level of agreement between flexible fiberoptic nasopharyngolaryngoscopy and indirect laryngoscopy for selected laryngopharyngeal conditions like vocal nodule, vocal cord polyp, Reinke’s edema, hypopharyngeal growth, vocal cord palsy, vocal cord growth. An Independent t-test and chi-square test were used to analyze the results. Statistical package for the social sciences (SPSS) version 20 was used for statistical analysis.
Methods: In this descriptive cross-sectional study, 101 patients with laryngopharyngeal symptoms were subjected to both indirect laryngoscopy and flexible fiberoptic nasopharyngolaryngoscopy. The structures visualized, pathologies detected, time taken and discomfort levels were statistically analyzed.  
Results: In our study, we found that laryngopharyngeal symptoms were more common among the 61 to 70 years age group. The majority of them were males. The majority of them were retired employees. The most common presenting complaint was difficulty in swallowing, followed by globus sensation and voice change. All structures were visualized by flexible fiberoptic nasopharyngolaryngoscopy. Whereas, in indirect laryngoscopy, some structures were visualized and some were not. Pyriform fossa apex and post-cricoid region were not visualized for all patients with indirect laryngoscopy. Laryngopharyngeal reflux was the most common pathology detected. There is no significant difference between IDL and FOL in site, subsite, and clinical appearance of the pathology detected. There is a significant difference between IDL and FOL in time taken (FOL has a higher mean) and discomfort levels (IDL has a higher mean).
Conclusions: Though indirect laryngoscopy is cost-effective in terms of investment, the time taken for the procedure is also less, flexible fiberoptic laryngoscopy is considered superior because it can visualize all structures and can detect pathologies early in their stage so that the patient gets treatment early which can alter the prognosis.
Awareness Among Medical Professionals about the Role of Physiotherapists in Patients with Chronic Renal Failure
Authors: Akanksha Patil , Trupti Yadav
Published: March 2024

Background: Chronic Renal Failure (CRF) is a significant health issue that has impacted millions of adults and elderly individuals. CRF arises from numerous miscellaneous conditions that irreversibly alter the function and structure of the kidney over months or years. It is non-recoverable and affects the body’s systems. Complications of CRF affect the patient’s quality of life, so physical rehabilitation plays a crucial role in enhancing quality of life. Materials and Methods: A self-administered questionnaire was developed, validated, and distributed as a Google form and circulated to medical professionals, including doctors and nurses, via social media platforms. The Data was automatically calculated using a Google spreadsheet. Results: 100 medical professionals filled out the questionnaire, of which 24 were doctors and 76 nurses. Among all participating medical professionals, 58.5% were cognizant of the role of physiotherapy in chronic renal failure, doctors were more aware than nurses. Conclusion: Medical professionals are less aware so, it is imperative to implement measures aimed at enhancing awareness about the role of physiotherapy in managing patients with CRF, as part of the management of complications and symptoms within the framework of a multidisciplinary team.
Development and validation of the inquiry-based nature of science and argumentation: A new instructional model on students’ scientific argumentation ability
Authors: Lestari Diah Puji , Paidi  , Suwarjo
Published: March 2024

One of the important goals of science education is to improve scientific argumentation ability which is part of the core practice of science. The main goals of this research are to develop and validate the inquiry-based nature of science and argumentation (IB-NOSA) instructional model which is designed to improve scientific argumentation ability. The research design in this study is Research and Development (R&D) using the steps proposed by Borg & Gall. The feasibility test of the IB-NOSA instructional model was assessed using the Focus Group Discussion (FGD) method, an assessment of the IB-NOSA model book, and an instrument test of scientific argumentation ability involving four experts. The practicality test was assessed by a lower secondary school science teacher. The data were analyzed using quantitative methods, and the validity and reliability indexes were calculated. The results of the study show that the IB-NOSA instructional model is feasible and practical. Meanwhile, the validation results of the scientific argumentation ability test instrument show that each item is in the range of 0.92 to 1. This indicates that each item is valid for further use. Therefore, it can be concluded that the IB-NOSA instructional model has feasibility and practicality for use in science learning and for developing the scientific argumentation ability of lower secondary school students.
Determinants of students’ satisfaction: Higher education perspective
Authors: Osman Abu Rashed , Joarder Mohd Hasanur Raihan , Ashraf Mohammad Ali
Published: March 2024

The intention of this paper is to verify students’ satisfaction through service quality, institutional image, and intake quality from a higher education perspective. To satisfy this objective, the study collected 303 data points randomly from North South University, Brac University, and United International University, the top three non-government institutions in Bangladesh. Results exhibited that service quality, institutional image, and the intake quality of students are statistically significant predictors of student satisfaction. As a result, these factors are appropriate for explaining student satisfaction. From a practical point of view, academicians, scholars, and practitioners should emphasize service quality, intake quality of students, and institutional image as major determinants of student satisfaction. It is challenging to maintain student satisfaction in institutes of higher learning. University administrators will have a great deal of opportunity to make useful judgments for boosting student satisfaction by comprehending this point of view and this study's conceptual model. Additionally, this research would have a big impact on both policymakers and academics. This study concentrated on aspects of higher education that students highly value. To fortify this conceptual model, the study incorporated "intake quality of student" as an independent variable for determining student satisfaction, which is a fairly extraordinary effort to expose a theoretical gap.
The influence of financial technology on profitability in Jordanian commercial banks
Authors: Jarah Baker Akram Falah , Alghadi Mohammad Yousef , Al-Zaqeba Murad Ali Ahmad , Mugableh Mohamed Ibrahim , Zaqaibeh Belal
Published: March 2024

The aim of this study is to identify the influence of Financial Technology (FinTech) on profitability in Jordanian commercial banks. The convenience sample was surveyed using a descriptive cross-sectional approach. Questionnaires were used to collect the data. The study population consists of commercial banks.  The tool was sent to employees of all Jordanian commercial banks through email, Facebook and Twitter in order to meet the researchers' target sample size of at least 381 participants. The data was analyzed using the Statistical Package for Social Sciences (SPSS) version 24. The results showed an impact of financial technology (financing, money transfers and lending) on banks' profitability. The results of this study demonstrate that the adoption of FinTech solutions by banks has a significant impact on their profitability and position. Financing, money transfer and lending are crucial in determining a bank's profitability and overall success. Therefore, this study contributed to the growth of a new model that connects financial technology through financing, money transfers and lending to profitability and it added many topics related to financial accounting technology for increasing profitability in Jordanian commercial banks.
Financial reporting quality and the performance of firms in Sub-Sahara Africa: The mediating role of firms’ characteristics
Authors: Aruobogha Onatuyeh Edwin , Jones Aniefor Sunday , Ogheneovo Orife Catherine
Published: March 2024

The purpose of this study is to test the validity of the mediating role of firms’ characteristics and its consequences on the financial reporting quality and performance of publicly quoted firms in sub-Saharan Africa. The study employed a quantitative approach and tested an existing theory by formulating relevant hypotheses. Measures of firms’ characteristics include the statistic factor (size) and dynamic factors (return on assets and return on equity as dependent variables; and discretionary cash flow from operating activities less net profit as an independent variable). The sample size consists of one hundred and twelve (112) public firms quoted on stock exchanges in three (3) sub-Saharan African countries from 2012 to 2022. Data obtained were analyzed using fixed effect and random effect panel data regression and structural equation modeling. The results revealed that financial reporting quality positively and insignificantly affects performance. However, financial reporting quality and firms’ performance were found to be positively and significantly affected when firms’ characteristics (size) were introduced. The implication of these results is that financial reporting quality alone cannot lead to an increase in firms’ performance. The size of the firm should be given due consideration to guarantee increased firm performance via high-quality financial reporting. Moreover, the results of this study are expected to offer information to the management of firms, enabling them to fulfill the condition of quality financial reporting so that investors and analysts of capital markets can benefit from determining informed investment decisions.
The Relationship of Toxoplasma Gondii Infection with Men Infertility: A Serological and Molecular Study
Authors: Eshraghi Samani Fahimeh , Kheiri Soleiman , Dezak Ebrahim Saedi , Seif Farhad , Dehkordi Maryam Nemati , Mokhtarian Kobra
Published: March 2024

Background and Aims: Toxoplasma gondii (T. gondii) is one of the most dangerous parasitic infections in immunocompromised patients. It may pass through the bloodstream to various organs, such as the reproductive organs of intermediate hosts, which may lead to male infertility. Therefore, this study aimed to determine the relationship between T. gondii infection and infertility in infertile men referred to the infertility center of Chaharmahal and Bakhtiari province.
Materials and Methods: In this case-control study,129 men, including 67 infertile and 62 fertile men, participated, and specific anti-Toxoplasma antibodies of IgG and IgM were detected in the serum of all cases using enzyme-linked immunosorbent assay methods. Also, the presence of T.gondii DNA in the seminal fluid samples of these people was detected using the polymerase chain reaction method. Sperm analyses, including sperm count, morphology, motility, and viscosity, were also performed on the seminal fluid.
Results: Based on the result of the IgG antibody, a significant difference was found in toxoplasmosis in two fertile and infertile groups. Its frequency was 16.1% in the fertile group and 40.3% in the infertile group. Also, Toxoplasma infection showed a relationship with sperm count and sperm morphology, so its frequency was 72.7% in the low sperm group and 24.6% in the high sperm group. The results of IgM and polymerase chain reaction showed, there was no significant relationship between the fertile and infertile groups with toxoplasmosis.
Conclusion: The serum prevalence of the anti-Toxoplasma antibodies and molecular detection in infertile men is higher than the control group, and it seems that Toxoplasma may be an effective risk factor for causing male infertility and disruption of sperm parameters.
The Effects of Vitamin C on Histological Changes Induced by Acrylamide on Rat Ovary
Authors: Ghaderi Nadia , Yadegari Maryam , Anvari Morteza , Talebi Alireza , Pourentezari Majid
Published: March 2024

Background and Aims: Acrylamide (ACR) adverse effects have been expressed in various tissues. Vitamin C protects the tissue from oxidative damage. The goal of this study was to examine the protective effects of vitamin C on histopathological changes induced by ACR on rat ovaries.
Materials and Methods: In this experimental study, 28 adult female Wistar rats were used. The animals (n=7) were divided into 4 groups (1) Control group, (2) ACR (10 mg/kg) group, (3) vitamin C (200 mg/kg), (4) ACR [10 mg/kg) + vitamin C (200 mg/kg) daily for 35 days. After the last oral dose, the ovaries were removed placed in the tissue processor, and molded. To determine the volume of the ovary and the number of follicles, we used the Cavalieri principle and the physical dissector, respectively.
Results: The results showed ACR increased the volume of the ovary (p ≤ 0.05), the volume of the medulla (p ≤ 0.01), and the decrease in the volume of the cortex (p ≤ 0.01) in comparison with the control group. These parameters were improved in the ACR + vitamin C group. The total number of primordial, primary, secondary, and graafian follicles showed a significant reduction in the ACR group compared to the other groups. The total number of follicles was increased in the ACR + vitamin C group.
Conclusion: Based on this study, we concluded that vitamin C can improve histopathological changes of the ovary in ACR-exposed rats
Comparative Evaluation of ELISA and Real-time PCR Tests to Detect COVID-19
Authors: Moshashei Saye , Bashi Zadeh Fakhar Haniyeh , Shaghaghi Babak , Jalalian Melika
Published: March 2024

Background: Considering the wide spread of covid-19 and its high death rate, it is very important to find a sensitive and accurate diagnostic method. Thus, this study compared two main diagnostic approaches; PCR and ELISA, to detect COVID-19.
Methods: Fifty patients admitted to Baghiyatalah Hospital were examined to detect COVID-19 RNA by Real-time PCR method, as well as for the presence of IgG and IgM antibodies by ELISA method. The results were statistically analysed by SPSS software.
Results: The mean age of patients is 38.4 years old. The percentage of positive cases of COVID-19 in the studied patients according to PCR and ELISA tests was 66% and 70%, respectively. There was a statistically significant difference between positive cases of COVID-19 detected by PCR and ELISA with emerging fever, weakness, and lethargy . The diagnostic value of ELISA versus PCR showed that the sensitivity, specificity, positive likelihood ratio, and true positive rate were 100%, 88.2%, 8.5, and 94.29%, respectively.
Conclusion: Although the sensitivity of detection in Real-time PCR is higher than that in ELISA, there is a high agreement between the two methods when used for diagnosis of COVID-19.
In Silico Exploring of the Antibiotic Adjuvant Potential of some Natural Ligands in Carbapenem-Resistance Acinetobacter baumannii
Authors: Hosseingholi Elaheh Zadeh , Molavi Ghader , Mohammadi Mohammad Sadra
Published: March 2024

Background: A. baumannii is a gram-negative pathogen that has become one of the most important challenges in the world due to its high antibiotic resistance, and today many efforts are being made to treat infections caused by it. In recent years, there have been many concerns about increasing resistance to the beta-lactam antibiotic, carbapenem. Because resistance to these antibiotics greatly narrows the treatment options for the infections. The main source of carbapenem resistance in A. baumannii is the production of class D carbapenemase enzymes.
Methods: In this study, 27 plant ligands that have been shown to have antibacterial effects against A. baumannii and other resistant bacteria were selected. The chemical structure of the ligands and the three-dimensional structure of carbapenemase OXA-58 were extracted. The requirements of oral consumption of ligands were examined and ligand and OXA-58 docking were performed. 9 ligands including baicalein, berberine, curcumin, ellagic acid, epicatechin, honokiol, magnolol, norwogonin, and thymol, which met the requirements of Rule 5 and had better binding affinity than 6-alphahydroxymethyl penicillanate were selected. Redocking with a focus on the active position was performed by AutoDock software.
Results: The amino acids involved in the hydrogen bonding of an antibiotic-representative ligand to the receptor were identified. Ligands that bind to at least one of these amino acids at the binding site by hydrogen bond were selected. Pharmacological and toxicity studies were performed and finally, the epicatechin ligand was introduced as the best ligand.
Conclusion: Plant ligands can be further investigated as promising antibiotic adjuvants and used in the future.
Hardiness among Ukrainians: challenges and opportunities
Authors: Chykhantsova Olena
Published: March 2024

The article deals with the phenomenon of hardiness and its characteristics. The structural components of hardiness are identified as commitment, control, and challenge. It is analyzed that hardiness characterizes the ability of an individual to withstand a situation of acute or chronic stress, to maintain internal balance without reducing the success of activities. It is noted that hardiness can be considered as an analog of a person’s vitality, which reflects the degree to which he or she overcomes certain life circumstances. The purpose is to study the hardiness among Ukrainians as a holistic personal formation, which is due to the interaction of personal resources. The sample consisted of 110 people from Ukraine. The Maddi and Kobasa Hardiness Test was used to diagnose the hardiness. The results show that a high level of hardiness of Ukrainians is associated with an active attitude to life, self-acceptance, using circumstances to one’s advantage, evaluating life situations as consciously chosen, and interpreting stressful situations as an opportunity to gain new experience. It has been established that hardiness has little to do with a person’s age, i.e. the development of hardiness can occur throughout life, starting from childhood, with the help of flourishing personal resources. According to the level of hardiness, 43.6% of Ukrainians had a high level, 35.5% ‑ an average level, and 20.9% ‑ a low level. The peculiarities of developing hardiness and maintaining the optimal level of this resource for personal effectiveness are related to worldview, personal goals, self-acceptance, mental health and activity.
Ecotourism Development Model in Indonesia: Quintuple Helix Inter-Organizational Collaboration Perspective
Authors: Wiyono S. Teguh , Lilik Ekowanti Mas Roro , Supartono  , Djoko Siswanto Muhartono
Published: March 2024

The ecotourism development model in Bangkalan Regency, especially in Labang District and Kamal District, cannot currently be handled in the usual way but requires breakthroughs and innovation with related stakeholders, such as the government, private sector, academics, media, society, and environmental sustainability. This article adopts a collaborative perspective from the Quintuple Helix inter-organizational collaboration model, to discuss stakeholder interactions and highlight the level of success and identification of several problems in the development of ecotourism on the Suramadu Bridge, Bangkalan Regency. Data collection was carried out through observation, semi-structured interviews, and document review. The research results show that collaboration between stakeholders and what occurs in the two sub-districts above in developing ecotourism from a quintuple helix inter-organizational collaboration perspective is still relatively not optimal. This is indicated by only a few optimal factors in implementing collaboration between stakeholders in the development of ecotourism. The development of eco-tourism from the perspective of quintuple helix inter-organizational collaboration in the two sub-districts above is not running optimally, because there are several obstacles, namely the existence of informal leaders and hidden institutions, which require more effort to invite them to sit together or further coordinate.
The Influence of Capital Structure, Company Growth, Liquidity, and Profitability on Company Value in Food and Beverages Sector Companies Listed on the IDX for 2017 - 2022
Authors: Purnamasari Dian Indri , Yuliana Putri
Published: March 2024

This study aims to examine the effect of capital structure, company growth, liquidity, and profitability on firm value. The population/object of this research is manufacturing companies in the food and beverages sector that have been listed on the Indonesia Stock Exchange (IDX) in 2017-2022. This study took samples using a purposive sampling technique that was selected based on certain criteria. Of the 27 manufacturing companies in the food and beverage sector listed on the Indonesia Stock Exchange (IDX) during 2017-2022, 16 companies met the criteria and could be used as samples in this study. The data analysis method used is a descriptive statistical test, a classic assumption test, which consists of normality test, heteroscedasticity test, autocorrelation test and multicollinearity test. In addition, multiple linear regression analysis, and hypothesis testing, namely the coefficient of determination and the T test.