bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges of Diagnosing Severe Malaria with Complications in Adult Patients: A Case Report
Authors: Bur Rika , Nelwan Erni Juwita , Danasasmita Ira , Hakim Gardian Lukman , Bahri Syukrini , Dewi Febby Elvanesa Sandra , Athaya Rana Zara , Nainggolan Leonard
Published: August 2023

Background: Malaria is known to be the main cause of death in malaria-endemic areas. The authors report a case of severe malaria in an adult with no history of travel from an endemic area with good outcomes after hospitalization.
Case Presentation: A 46-year-old man was brought to the Emergency Room (ER) because of fever and chills for six days. Complaints were accompanied by nausea and vomiting three times a day. Patients also experience headaches, weakness, coughing, and runny nose. The patient had no history of traveling from a malaria-endemic area. The patient was transferred from the Emergency Department (ED) to the High Care Unit (HCU), and during one day of intensive medical care at the HCU, there was a clinical deterioration characterized by dyspnea, icteric sclerae, acral edema, tenderness in both calves, and rash in the abdominal area. Due to worsening respiratory function, the patient was placed on a ventilator. During intensive medical treatment, the patient continued to show deterioration. The clinical findings suggest a possible feature of Weil's disease or fulminant hepatitis, and although the patient was on intensive care, there was no clinically significant improvement. Furthermore, microscopic blood smear examination and rapid diagnostic tests (RDTs) for malaria were carried out on the 4th day of treatment with negative results. As there was no clinically significant improvement, it was decided to take a blood smear and repeat RDT on the twelfth day, and it showed a positive result for falciparum malaria. Subsequently, artesunate was administered intravenously, and the patient's condition began to improve with a negative parasite count the following day. The patient was discharged in good clinical condition on day 25 of treatment.
Conclusion: Good quality malaria diagnostic techniques are essential to diagnose malaria. A timely diagnosis of malaria has the potential to save the patient. Because Jakarta is not a malaria endemic area, it was concluded that this case was an imported malaria case.
Association between aspirin dose and outcomes in patients with acute Kawasaki disease: A nationwide retrospective cohort study in Japan
Authors: Suzuki Takanori , Michihata Nobuaki , Hashimoto Yohei , Yoshikawa Tetsushi , Saito Kazuyoshi , Matsui Hiroki , Fushimi Kiyohide , Yasunaga Hideo
Published: August 2023

Background Using a Japanese national inpatient database, this study aimed to identify the appropriate dose of aspirin to be prescribed to patients with acute Kawasaki disease. Method We identified patients with Kawasaki disease treated with intravenous immunoglobulin between 2010 and 2021.The outcomes included the occurrence of coronary artery abnormalities and intravenous immunoglobulin resistance, length of stay, and medical costs. Restricted cubic spline functions were performed to examine the association between aspirin dose and the outcomes. Results Data of 82109 patients were extracted from the database. Non-linear associations were observed between aspirin dose and the outcomes. In comparison with an aspirin dose of 30 mg/kg/day, the odds ratio (95% confidence interval) for coronary artery abnormalities was 1.40 (1.13–1.75) at 5 mg/kg/day. An aspirin dose of ≥ 30 mg/kg/day did not significantly change the odds ratio for coronary artery abnormalities. Intravenous immunoglobulin resistance was significantly lower at a dose of 60 mg/kg/day or over. Conclusions The results showed no significant association between aspirin escalation and CAAs in patients with acute KD. High-dose aspirin showed the potential to reduce hospital stay and medical costs without increasing complications.
Bacteria inhabiting spider webs enhance host silk extensibility
Authors: Tsiareshyna Maryia , Wang Te-Hsin , Lin Yin-Sheng , Piorkowski Dakota , Huang Sammi Yen-Ting , Huang Yi-Lun , Chao Wei-Ting , Chang Yuan-Jay , Liao Chen-Pan , Wang Pi-Han , Tso I-Min
Published: August 2023

Spider silk is a promising material with great potential in biomedical applications due to its incredible mechanical properties and resistance to bacterial degradation, particularly commercially available strains. However, little is known about the bacterial communities that may inhabit spider webs and how these microorganisms interact with spider silk. In this study, we exposed two exopolysaccharide-secreting bacteria, isolated from webs of an orb spider, to major ampullate (MA) silk from host spiders. The naturally occurring lipid and glycoprotein surface layers of MA silk were experimentally removed to further probe the interaction between bacteria and silk. Extensibility of major ampullate silk produced byTriconephila clavatathat was exposed to eitherMicrobacteriumsp. orNovosphigobiumsp. was significantly higher than that of silk that was not exposed to bacteria. This strain-enhancing effect was not observed when the lipid and glycoprotein surface layers of MA silks were removed. The presence of exopolysaccharides was detected through NMR from MA silks exposed to these two bacteria but not from those without exposure. Here we report for the first time that exopolysaccharide-secreting bacteria inhabiting spider webs can enhance extensibility of host MA silks and silk surface layers play a vital role in mediating such effects.
Finite element analysis of convective heat transfer in a linearly heated porous trapezoidal cavity in the presence of a magnetic field
Authors: Suchana Sanzina Sultana , Ali Mohammad Mokaddes
Published: August 2023

A computational study is carried out to examine how a magnetic field affects convective heat transfer in a linearly heated trapezoidal cavity, filled with a fluid-saturated by porous medium. Both inclined walls are adiabatic, with the top wall maintaining a constant cooled temperature Tc which is moving with a constant velocity U0 in the positive x-axis direction, and the bottom wall being heated linearly which is moving with a constant velocity that is the same as that of the top wall but in the opposite direction. The finite element technique is utilized to resolve the governing equations associated with appropriate initial and boundary conditions. The resulting solutions are represented graphically in respect of streamlines, isothermal lines, and thermal gradient magnitude for an extensive range of Darcy numbers (10− 2 ≤ Da ≤ 10− 5), Hartmann numbers (0 ≤ Ha ≤ 100), and Prandtl numbers (0.7 ≤ Pr ≤ 15). The findings indicate the enhancement of flow circulation concerning the higher values of Darcy number but the reduction of that with the higher values of Hartmann number as well as Prandtl number. In addition, the temperature distribution is affected by various values of the Darcy number and Hartmann number. It is also reflected that the rate of convective heat transfer declines with the growing values of the Hartmann number and the decreasing values of the Darcy number and Prandtl number.
Evaluation of plateau wetland ecological security and its influencing factors in multi-climatic zones: A case study of Yunnan Province
Authors: Chen Zhe , Zhang Chunhong , Chen Zhe
Published: August 2023

Plateau wetlands play an important role in social and economic development and ecological security. The ecological environment of a plateau wetland is fragile and vulnerable to external interference, resulting in changes in the wetland structure and ecological functions. Ecological security assessment of plateau wetlands is the key to fully understanding their ecological security situation. Yunnan Province, which is located in the Qinghai-Tibet Plateau, has a significant stereoscopic climate, which is characterized by distinct features of diverse and complex wetlands. Thus, studying the wetland ecological security of Yunnan Province spanning various climatic zones is of great significance. In this study, an improved pressure-state-response model was constructed, and an index system containing state and social pressure was established using remote sensing data, Yunnan Province Yearbook data, and socioeconomic statistical data. Taking 16 prefectures in Yunnan Province as samples, this study weighted the evaluation indices via the combination of entropy weighting and expert weighting. In addition, the wetland ecological security state in Yunnan Province in 2017 was evaluated using the fuzzy matter-element method, and the influencing factors were analyzed. Results showed that the highest ecological security index of wetland was distributed in Nujiang, Diqing in the northwest of Yunnan Province and Xishuangbanna in the south, whereas the lowest area was in Qujing, Zhaotong in the northeast of Yunnan Province and Baoshan in the west. Differences were observed in the influencing factors of wetland ecological security in different prefectures. In general, the influencing factors in Yunnan Province were the annual average temperature, proportion of natural wetland, percentage of secondary industry, annual precipitation, wetland ecological service function per unit acreage, fertilization intensity, and industrial water recycling rate. The results of grey correlation analysis showed that climatic factors and human disturbance activities were the main influencing factors of wetland ecological security in Yunnan Province, and the influence rate of the two was close to each other. The findings of this work could provide suggestions for the decision making on ecological security development in plateau wetlands across multi-climate zones, as well as data support for the ecological protection of plateau wetlands.
The synergistic effect of EGCG and conditioned medium derived from WJ-MSCs on androgen receptor and apoptotic signaling pathways of prostate cancer LNCaP cells
Authors: Mohammadi Reihane , Fazeli Zahra , Daraei Azam , Asgari Katayoon
Published: August 2023

Prostate cancer (PCa) was known as the second most common cancer in men. Although there were several approaches to treat this disease, the cost and side effects of some approaches have encountered the patients with challenges. Therefore, the design of new therapy methods could be useful in the management of this disease. For this purpose, the synergic effect of Epigallocatechin gallate (EGCG) and conditioned medium derived from Wharton's jelly mesenchymal stem cells (WJ-MSCs) were studied on prostate cancer LNCaP cells. In this study, LNCaP cells were treated with different concentrations of EGCG and conditioned medium derived from WJ-MSCs (WJCM). The viability of treated cells was determined by using MTT assay. Then, the expression of androgen receptor (AR and PSA) and apoptotic (BAX, CASP3 and CASP7) pathway genes were defined by Real time PCR. The analysis of the data indicated that the treatment with 400µM EGCG in combination with 50% WJCM (0% FBS) for 72 hours decreased expression of AR and PSA genes as well as the enhanced expression of BAX, CASP3 and CASP7 genes in the LNCaP cells (p < 0.05). The obtained results suggested that the combination therapy of EGCG and WJCM had an anticancer effect on LNCaP cells through activation of apoptotic pathway and suppression of androgen receptor pathway.
Effect of Solid-Electrolyte Pellet Density on Failure of Solid-State Batteries
Authors: Ceder Gerbrand , Diallo Mouhamad , Shi Tan , Zhang Ya-Qian , Peng Xinxing , Shozib Imtiaz , Wang Yan , Miara Lincoln , Scott Mary , Tu Howard
Published: August 2023

Despite the potentially higher energy density and improved safety of solid-state batteries (SSBs) relative to Li-ion batteries, failure due to Li-filament penetration of the solid electrolyte and subsequent short circuit remains a critical issue. Herein, we show that Li-filament growth is suppressed in solid-electrolyte pellets with a relative density beyond ~ 95%. Below this threshold value, however, the battery shorts more easily as the density increases due to faster Li-filament growth within the percolating pores in the pellet. The microstructural properties (e.g., pore size, connectivity, porosity, and tortuosity) of 75%Li2S - 25P2S5 with various relative densities are quantified using focused ion beam–scanning electron microscopy tomography and permeability tests. Furthermore, modeling results provide details on the Li-filament growth inside pores ranging from 0.2 to 2 µm in size. Our findings improve the understanding of the failure modes of SSBs and provide guidelines for the design of dendrite-free SSBs.
The wave mechanics for microwave absorption film-Part 3: Film with multilayers
Authors: Liu Yue , Liu Ying , Drew Michael
Published: August 2023

In the field of microwave absorption, the quarter wavelength theory (QWM) is usually applied to film with multiple layers. However, it is demonstrated here that this is inappropriate since QWM is a flawed theory. The results for the conventional film with or without metal-back are usually applied to the middle layers in multilayer film. But this is inappropriate since there are incident microwaves at both sides of the middle layer but only the incident microwaves in front of the film are considered. No suitable theoretical treatment for multilayer film has been developed so far and this has been done in this work.
Market crash factors and developing an early warning system: Evidence from Asia
Authors: Kustina Lisa , Sudarsono Rachmat , Effendi Nury
Published: August 2023

Market crashes pose significant risks to the stability and performance of financial markets, making the development of an early warning system crucial. This study utilizes exchange rate volatility and investor sentiment to predict market crashes. While several studies have examined factors affecting market crashes in developing countries. This study aims to develop an early warning system for investors to minimize investment risk using Exchange Rate Volatility and Investor Sentiment. The study focused on seven countries: Indonesia, Malaysia, Singapore, the Philippines, Thailand, Vietnam, and Mongolia. The stock exchanges examined included Jakarta Stock Exchange Composite, FTSE Malaysia KLCI, FTSE Singapore, SET Index, PSEi, HNX/HNXI, and MNE Top 20/MNETOP20. The analysis involved assessing early warning systems to provide valuable supplementary information for decision making and evaluating market vulnerabilities. The logistic regression equation was utilized to model market crashes, incorporating variables such as exchange rate volatility and investor sentiment while considering their interactions as moderating factors. The results indicate that exchange rate volatility and investor sentiment have a significant negative effect on market crashes, with probabilities of 0.0082 and 0.000 Furthermore, investor sentiment acts as a mediator for exchange rate volatility, amplifying its impact on market crashes. This suggests that higher exchange rate volatility and negative investor sentiment increase the likelihood of market crashes. Exchange rate volatility and investor sentiment can serve as early warning indicators, emphasizing the importance of monitoring these factors for market participants and policymakers.
Atlantismo no Atlântico Sul Comunidade de interesses e governança oceânica Juan Luis Suárez de Vivero
Authors: Suárez de Vivero Juan Luis , Villela Marroni Etiene , Rodríguez Mateos Juan Carlos , de Lima Figueiredo Eurico , Rocha Violante Alexandre
Published: August 2023

O objetivo deste artigo é analisar em que medida a governança da bacia Sul Atlântica leva à construção de uma comunidade transatlântica no Hemisfério Sul com foco na economia e política marítima, bem como conceitos jurisdicionais da governança no Atlântico Sul. Também visa compreender como a configuração de estruturas institucionais interferem nesse sistema e se configuram como frágeis laços político-culturais e econômicos transatlânticos. Embora no Atlântico Sul – diferentemente da Bacia do Norte – não tenha sido construída uma poderosa rede de interesses comuns, a expansão jurisdicional exige que Estados Costeiros adotem políticas marítimas proporcionais à magnitude da responsabilidade territorial adquirida, a qual a sub-bacia americana (especificamente Brasil e Argentina) propugna por uma posição de dominância ao sul do paralelo zero.
Policy Diffusion by means of Defense and Security Simulations and the uses of agent-based modelling
Authors: Bravo e Paiva Ana Luiza , Evangelista Medeiros Sabrina , Sandes Monfredo Mendes Cintiene
Published: August 2023

This paper is about three elements: inter-agency cooperation simulations with security and defense practitioners as actors; policy diffusion as a way of innovative and incremental gains using practices and the observation of behaviors; and, agent-based modelling as a tool to enhance performance, observing tendencies and acquiring more visibility of the processes and practices imbibed. For this, the first part of the paper is focused on the uses of the literature that expresses decision making process behaviors as a fundamental part of the institutionalization process in terms of cooperation. Adaptive institutionalization is the core element of this approach; in which we believe policy diffusion can derive progressively and in an incremental way. Secondly, we are going to present the inter-agency simulation cases we are working with as part of an inter-institutional effort; researching on those ties and proposing new forms of arrangements and possibilities of increasing dynamics efficiency in the sector, observing both the cases and the exercises chosen in agent-based modelling (ABM)
CURRÍCULO E AUTONOMIA DOCENTE: ENUNCIAÇÕES POLÍTICAS
Authors: ALVES ELIANE FERNANDES GADELHA , RODRIGUES ANA CLAUDIA SILVA
Published: August 2023

Trata-se de uma obra importante para analisar as tensões em torno da autonomia de professores, no movimento de proposição do projeto político-pedagógico. Traz uma análise fundamentada na Análise Crítica do Discurso, na qual evidencia as vozes de professoras de educação básica. Considera fundamental ouvi-las, especialmente quando pensamos políticas curriculares de formação.
ASPECTOS TEÓRICO-METODOLÓGICOS DA PRODUÇÃO DO CONHECIMENTO SOBRE REGULAÇÃO E GESTÃO POR RESULTADOS NO CAMPO DA POLÍTICA EDUCACIONAL (2015-2020)
Authors: Serighelli Marco André , Nardi Elton Luiz
Published: August 2023

O trabalho tem por objetivo traçar uma delimitação do conhecimento acerca da temática regulação e gestão educacional por resultados, veiculada por trabalhos acadêmicos da área da Educação, datados de 2015 a 2020, na especificidade dos aspectos teórico-metodológicos mobilizados. Para tanto, serve-se de publicações na forma de teses disponíveis no Catálogo de Teses e Dissertações da Capes, acessadas por meio da aplicação de descritores e de filtros, cuja análise incide em um conjunto de aspectos do domínio teórico- metodológico. Os resultados evidenciam coerência entre temas enfocados e linhas de pesquisa dos autores e aderência entre níveis de análise, referenciais teóricos e abordagens adotadas, além da prevalência de posicionamento crítico, com estabelecimento de relações centrais à compreensãoda temática.
O (DES)CUMPRIMENTO DOS PLANOS MUNICIPAIS DE EDUCAÇÃO COM A GESTÃO DEMOCRÁTICA
Authors: Dos Santos Almir Paulo
Published: August 2023

Este trabalho discute a gestão democrática no âmbito das associações de municípios nos três estados da Região Sul do Brasil, tendo por objetivo analisar como os órgãos normativos explicitam seus limites e suas possibilidades para a gestão escolar democrática, no âmbito dos Planos Municipais de Educação. A metodologia é qualitativa e de análise documental. Observou-se a necessidade de avançar a perspectiva de gestão democrática, no aspecto da legislação municipal em relação à conexão entre o texto expresso com os atores escolares para a formulação de políticas educacionais municipais.
Sexual Harassment against Female Nurses at Hospitals in Jakarta, Indonesia
Authors: Syaebani Muhammad Irfan , Zen Wahyu Muhamad , Devina Monica , Nikmah Uliyatun , Primadini Dindha Vitri
Published: August 2023

Sexual harassment of female employees in the workplace is a pervasive problem, especially in hospitals that rely on nurses to deliver medical care through physical contact with several patients, therefore increasing their risk of sexual harassment. The purpose of this study is to examine the circumstances and experiences of sexual harassment against female hospital nurses in Jakarta, Indonesia. The research employed a qualitative, phenomenological approach, with eight informants participating in In-Depth Interviews and coding analysis. According to the subjects of the study, sexual harassment happened during work hours, making them victims. Sexual harassment can range from subtle to overt, from gestures to physical assault. The majority of perpetrators are male. While female nurses are providing medical treatment, visiting patients, or engaging in training, sexual harassment may occur. The findings point to preventative strategies such as policy development, training, and increasing public awareness of sexual harassment, as well as a coping strategy that involves assisting victims in reporting their experiences through an established grievance procedure system to reach a fair resolution.
Housing Rights of Orphans: Problems of Legal Guarantees
Authors: Nikolaeva Kseniya
Published: August 2023

The Russian Federation as a welfare state has to guarantee social protection for certain target groups, one of which is orphans. Housing rights of orphans are central in the complex of social rights, but the problem of inability to secure housing for orphans remains unresolved. The purpose of the study is to analyze how the housing rights of orphans are realized in the judicial practice, to identify the causes of violations of legislation and to develop recommendations for its improvement. The article uses a neoinstitutional approach that allows to analyze the practice of implementing housing rights of orphans and the problems faced by orphans in the implementation of their housing rights. The study identifies the most frequent violations of the housing rights of orphans, considers the court decisions, and formulates recommendations for improving the normative acts regulating the housing rights of orphans.
Preserving the Integrity of Organizations’ Quality Management System during Unification and Integration: Functional Approach
Authors: Sokolovskaya Marina , Zamiralova Elena
Published: August 2023

The article addresses the problems of preserving the integrity of quality management systems during integration of educational organizations into a single educational complex. The purpose of the article is to develop and test a functional approach of combining two educational organizations of different levels that preserves the integrity of existing quality management systems. The authors use methods of analysis, synthesis, generalization and comparison as well as system analysis, identification of cause-and-effect relationships, process and system approach, internal audits, self-assessment, expert assessment, ranking. The article considers the concept of integrity and related concepts. The authors propose a functional approach that uses several stages to maintain the integrity of quality management systems in compliance with all the rules for making changes to management systems and the principles of educational organizations integration. The approach is tested on a university and a college. The analysis identified the main categories of changes in organizations’ quality management system during integration and developed a synergetic model of the organization. The results can help improve the integrated quality management system in the future, not only in the field of education, but also in other areas of the economy.
Specifics of Digitalization in Russia and its Regions under Uncertainty
Authors: Hashir Bella , Shvetsova Irina , Usanov Alexander , Ponomarev Sergey
Published: August 2023

The purpose of the article is to reveal the specifics of digital development in Russia and its regions in the conditions of increasing uncertainty and to determine the directions of state policy that would ensure improvement in the economic system's stability. The authors use the analysis of theoretical literary sources, analysis and synthesis, systematization, comparative and economic analysis. Research identified three periods of uncertainty. Despite the positive dynamics of digitalization, in the period before the pandemic, the digital development of Russian regions was uneven. The uncertainty caused by the COVID-19 pandemic has led to the intensification of digital development, as well as launched new socio-economic transformations. The study revealed the tendency to increase expenditures on regions’ digitalization during the period of geopolitical tension and determined state policy directions for overcoming the negative impact of geopolitical uncertainty on economic systems. Financial and economic uncertainty has not become an obstacle to the development of a digital society. On the contrary, the expansion of digital infrastructure and social progress created conditions for its intensification.
The effect of soil porosity size distribution on integral energy content of water in different moisture slopes
Authors: Dai Liuben , Xu Zhaolei
Published: August 2023

The water required by the plant is provided through the porous environment of the soil around the root. Therefore, indicators such as soil texture and effective porosity have been defined to measure the amount of water available to the plant. The pore size determines water energy and the plant's ability to absorb moisture, which is evaluated in this article. Multivariate regression analysis between the integral energy of water in different ranges of humidity as the dependent variable and the indices of soil pore size distribution as the independent variable has been investigated. Due to the fact that none of the indices of the pore size distribution curve have a significant relationship with the integral energy value of water in the permanent wilting point, therefore, it was not possible to estimate this index using the indices of the pore size distribution curve. The results showed that the elongation index of soil pore size distribution curve is the only factor determining the amount of integral energy of water in different soil water contents.
relação entre a satisfação de ensinar e o método das Boquinhas®
Authors: Rangel Alexandra Fernandes Morais , Jardini Renata Savastano Ribeiro , Bongiovani Anair , Tosta Estela Inês Leite
Published: August 2023

A alfabetização gera impactos em toda a vida do indivíduo, sendo um momento em que a criança é inserida na sociedade, tornando-se parte desse grupo. Insucessos nessa aquisição podem acarretar consequências emocionais para todos os envolvidos, educadores e aprendizes. Os objetivos dessa pesquisa foram investigar o grau de satisfação, motivação, autoestima, envolvimento profissional e facilidade dos professores/clínicos, que aplicam o Método das Boquinhas®[1] no processo de alfabetização e reabilitação, bem como sua apreciação sobre os mesmos sentimentos em relação ao seu aprendiz. Trata-se de uma pesquisa de natureza quantitativa, na qual foram aplicados dois questionários, e os resultados obtidos apontaram altos índices de confiabilidade em todos os itens pesquisados, tanto na percepção do educador, como de seu educando. Também houve alta correlação significativa, principalmente na maior quantidade de cursos realizados e tempo de estudos em relação à aprendizagem e recomendação da metodologia. Concluiu-se, portanto, que o educador sente benefícios para si e para seus aprendentes ao aplicar a metodologia Boquinhas.
 
[1] Método de alfabetização multissensorial, fonovisuoarticulatório, registrado por Renata Jardini, em 2008, com INPI para produtos e serviços. Disponível em: www.metododasboquinhas.com.br. Acesso em 10: dez. 2022.
Discovery Phenolic Profiles and in vitro Antioxidants, Neuroprotective,
Anti-diabetic Activities of Extracts from of Algerian Plant: Calendula
monardii Boiss. & Reut
Authors: Samai Zakaria , Toudert Nadia , Dadda Noureddine , Hamel Tarek , Zakkad Farida , Zerrad Chaima , Boutemedjet Sihem , Bensouici Chawki , Djilani Salah Eddine
Published: August 2023

The present study examines the potential effect of Calendula monardii (Boiss. & Reut.) on
inhibiting various enzymes involved in many diseases.

Background:

Calendula suffruticosa subsp. monardii (Boiss. & Reut.) Ohle, a medicinal plant from the
Mediterranean region and, more precisely, from the extreme northeast of Algeria, is characterized by its
wide use in the traditional medicine of the local population. This is what prompted us to investigate
some pharmacological benefits such as anti-diabetes and Alzheimer's activities, in addition to antioxidant
activity.
The effects of extraction methods and solvents on the amount of phenolic profiles and the biological activity
of the different parts of this plant were studied, where the aim was to obtain a high extraction
yield of bioactive compounds and consequently high biological activities.

Methods:

In vitro standard procedures were used to assess enzyme inhibitory activity (AChE, BChE, α-
Amylase and α-Glucosidase) of Calendula monadii, and the antioxidant activity was assessed using the
DPPH, ABTS, CUPRAC, Reducing power and Ferrous ions assays.

Results:

When using ultrasound, a significant increase in the amounts of (TPC, TFC and TFlas) and antioxidant
activity (DPPH, ABTS, CUPRAC, Reducing power and Ferrous ions cheating assay) in addition
to the inhibitory activity of enzymes (AChE, BChE, α-Amylase α-Glucosidase) was found, compared
to the results of conventional extraction. Furthermore, the aqueous solvent of ethanol 70% is the
very effective solvent for extraction compared to methanol 70% aqueous solvent.

Conclusion:

Based on these results, it can be said that this plant contains important biological activities,
so it can be used in phytotherapy.
Expression of MicroRNA-200a/b/c in the Mediobasal Hypothalamic Nuclei with Aging
Authors: Porseva Valentina V. , Pankrasheva Lydia G. , Moiseev Konstantin Yu , Anfimova Polina A. , Emanuilov Andrey I. , Levshin Nikolay Yu. , Baranov Andrey A. , Masliukov Petr M.
Published: August 2023

Background:

MicroRNAs (miRNAs) belong to small non-coding RNAs that coordi-nate the expression of cellular genes at the post-transcriptional level. The hypothalamus is a key regulator of homeostasis, biological rhythms and adaptation to different environmental factors. It also participates in the aging regulation. Variations in miRNA expression in the hypothalamus can affect the aging process.

Objective:

Our objective of this study is to examine the expression of miR-200a-3p, miR-200b-3p, miR-200c-3p in the dorsomedial (DMN), ventromedial (VMN) and arcuate (ARN) nuclei of the hypothalamus in male and female rats during aging.

Methods:

The expression of miR-200a-3p, miR-200b-3p, and miR-200c-3p in DMN, VMN and ARN was studied by qPCR-RT. The results were presented using the 2-ΔΔCq algorithm.

Results:

The expression of miR-200a-3p, miR-200b-3p, miR-200c-3p microRNAs decreases with aging in the DMN of males and in the VMN of females. The level of miR-200b-3p expression de-creased in aged males in the VMN and females in the DMN. The expression of miR-200c-3p de-clined in aged males in the ARN and in females in the DMN. The expression of miR-200a-3p, miR-200b-3p, and miR-200c-3p did not change in females in the ARN in aging.

Conclusion:

We found a decrease in the expression of members of the miR-200a-3p, miR-200b-3p, and miR-200c-3p in the tuberal hypothalamic nuclei and their sex differences in aging rats.
Ultrasonic Study of Novel Polymer Dextran in Aqueous Media at 12 MHz
Authors: Panda Subhraraj
Published: August 2023

Background:

The characteristics of matter and the dynamics of molecular processes are examined by acoustic approaches. The primary techniques in molecular acoustics are the measure-ment of sound speed and sound absorption, as well as the relationship between these quantities and different physical variables including pressure, temperature, and wave frequency. Molecular acoustics emerged as a separate field in the 1930s. When it was discovered that many substances disperse the speed of sound during the transmission of sound waves through them and that the classical law, which states that the coefficient of absorption is proportional to the square of the frequency, however, it does not adequately describe how sound is absorbed.

Objective:

The ultrasonic technique is employed because it is one of the most popular techniques, which is very easy to use, and provides precise velocity results. With careful analysis of the results, the correlation between solute and solvent was discovered. In the pharmaceutical, agricultural, and cosmetics industries, dextran and its derivatives from a few select strains have found a wide range of uses. This is why we have chosen it for our study. For assessing the impact of temperature and con-centration on the aqueous medium containing the polymer dextran, ultrasonic properties are crucial. Pycnometer, Ostwald viscometer, and ultrasonic interferometer were used respectively to measure density (ρ), viscosity (η), and ultrasonic speed (u) at "303 K, 308 K, 313 K, 318 K, and 323 K." The experimental parameters are used to determine the acoustic parameters "adiabatic compressibility, Intermolecular free length, relaxation time, acoustic impedance, and Gibb's free energy".

Method:

To measure the density, viscosity, and ultrasonic velocity of the solution using a pycnome-ter, an Ostwald's viscometer, and an ultrasonic interferometer, and to calculate the thermo acoustical parameters based on the measured parameters.

Result:

Applications for examining the physico-chemical behaviour of aqueous dextran using ultra-sound include understanding the nature of molecular interactions.

Conclusion:

It was investigated how concentration and temperature affected the thermoacoustic char-acteristics of aqueous dextran. Hydrogen bonds, charge transfer complexes, and the dissolution of hy-drogen bonds and complexes are only a few examples of the forces that exist between molecules and how the analysis has interpreted their nature. Weak intermolecular forces exist.

Other:

Recent developments in ultrasonic techniques have made them an effective tool for evaluating information regarding the physical and chemical behaviour of liquid molecules.
Phytochemicals Present in Ethanol Extract of Avocado Seed and Its
Potential Antioxidant Effect
Authors: da Silva Bastos Kaio Vinicius Lira , Souza Adriana Bezerra , Gomes Rodolfo Rodrigues , de Souza Leticia Cherpe , Aquino Isabella Pacifico , de Moura Souza Felipe
Published: August 2023

Introduction:

Pharmaceutical research currently focuses on methods that allow for more sustainable and natural approaches. In this way, the use of discarded by-products, such as avocado seed, becomes a profitable and sustainable practice.

Methods:

This study evaluated the extraction of phytochemicals from avocado seed (Soxhlet extraction) and compared the antioxidant capacity of avocado seed (DPPH method). The extraction found compounds of different hydrophobicity and a vast amount of compounds that may present the potential for future clinical trials.

Results:

Avocado extract presented an antioxidant effect (AA%) more effective than Quercetin (3.5%), Ascorbic Acid (2.8%,) and lightly lower than Rutin (-1.9%).

Conclusion:

Therefore, the avocado seed can be an excellent alternative for research of antioxidants and therapeutic phytochemicals.
Antibiotic Resistance Pattern of Escherichia coli Derived from Retail Raw Meat in North Sumatera, Indonesia
Authors: Dewi Rita Rosmala , Berutu Karina Mia , Sihombing Juli Mutiara
Published: August 2023

Bacteria from animals raised for food that have developed antimicrobial resistance (AMR) may serve as a vehicle for its transmission from animal to human. Nevertheless, the antibiotic resistance profile of Escherichia coli from raw meat is scarcely reported, especially in North Sumatra. The aim of this investigation was to investigate the retail raw meat for the presence of E. coli and its antimicrobial resistance pattern. We purchased 80 packages of fresh meat products from four traditional markets located in Deli Serdang and Medan. Escherichia coli was isolated by an established microbiology test and a phenotypic antimicrobial susceptibility test was conducted by the method of disk diffusion. The data analysis of antibiotic resistance and multi-drug resistance (MDR) levels was performed by using WHONET 5.6. The antibiotic resistance dissimilarity between the two regencies was analyzed by using chi-square analysis. This study observed about 19 E coli isolates (23.7%) were obtained from raw meat. Resistance toward the antibiotics listed as critically important for veterinary and human therapy is increasing concern for public health. The isolates were highly resistant to ampicillin and tetracycline. Meanwhile gentamycin is susceptible. The MDR level of E. coli in both regencies of North Sumatra was about 21.05%. This finding contribute essential information on AMR in food animals and can be used to improve local and regional plans for the administration of antibiotics to livestock.
Hip to Be Square: Moral Saints Revisited
Authors: Ryan Liam D.
Published: August 2023

I defend the continuing importance, and attraction of, moral saints. The objective of this paper is twofold; firstly, to critique Wolf’s definition of sainthood, and secondly, to argue against her view that one should not desire to be a moral saint, nor emulate them. In section 1, I argue that moral saints are highly complex moral agents, and that Wolf’s definition does not capture this complexity. My second argument is that Wolf’s account that there are two kinds of saints, loving and rational, leads to a tension. Either: (1) the distinction between loving and rational saints is justifiable; but then arguments against the benefits of sainthood ought to be directed independently against each kind of saint which, Wolf does not do; or (2) the distinction is not justifiable, in which case the division is explanatorily impotent. In section 2, I will present Wolf’s argument for why one should not want to be a moral saint, nor even know one. I counter that Wolf over-emphasises non-moral values, to the point that these values have a monopoly on what constitutes a well-rounded life. Wolf must provide a more definitive scope for non-moral values, as the distinction between moral and non-moral values is ambiguous. Finally, I argue that moral saints can serve as moral exemplars and visionaries. By admiring and emulating them, we can adapt our own moral behavior, and by example, moral saints can discover new and better ways of pursuing moral goods.
Idioms and Proverbs With a Plant Component in English Language and Culture
Authors: Wang Q.
Published: August 2023

The article is aimed at analyzing the symbolic specificity of the Plant component, being a part of idioms and proverbs, formulating English language and culture ground.

The research methodology is complex and is based two groups of methods, which are general scientific methods group, including analysis and synthesis, generalization, and special methods group, including the descriptive method, the method of component analysis, and the quantitative method.

The research proves that the symbolic component, being the part of idioms or proverbs, make specific images in a person's mind causing special associations. The Plant component in idioms and proverbs especially in modern English culture is an integral part formulatung special part of lexis in English culture. The author identifies such subgroups of Plant components as part of idioms and proverbs as “tree components”, “tree names components”, “tree parts components”, “tree fruit components” and systematizes their properties from the standpoint of language and culture symbiosis understanding. The research asserts that the qualities typical for Plant components realization are associated with a person and various aspects of his activity.

The research work results in two groups of idioms and proverbs with a Plant component classification types revealing main aspects of British culture by means of symbolic ideas: the group “man” describing peculiar features of man’s appearance, character, speech, mental abilities; and the group “specific features of human life”, being subdivided into subgroups “material life” and “immaterial life”, representing the features of tangible and intangible values of English language and culture.
Неадиабатические переходы атомов и образование зародышей новой фазы в твердых телах
Authors: Хон Ю.А.
Published: August 2023

A mechanism for the formation of nuclei of a new phase in a solid is proposed, determined by nonadiabatic Landau-Ziner transitions in an open system of nuclei and electrons. Based on the analysis of the equations of nonadiabatic molecular dynamics, two order parameters are identified. The dynamics of the nucleation and growth of the embryo is determined by two related nonlinear parabolic equations for order parameters. The conditions for the formation of stable and unstable embryos are found. It is shown that the formation of the embryo can proceed in an auto-oscillatory mode. The influence of the heating (cooling) rate on the formation of new phase nuclei is considered.
Влияние температуры спекания на микроструктуру и диэлектрические свойства Bi-=SUB=-4-=/SUB=-Ti-=SUB=-3-=/SUB=-O-=SUB=-12-=/SUB=-, легированного неодимом
Authors: Зубков С.В. , Паринов И.А. , Назаренко А.В. , Павленко А.В.
Published: August 2023

A new set of perovskite-like Bi4-xNdxTi3O12 (x=0.1, 0.3, 0.5, 0.7) oxides were synthesized by the method of high-temperature solid-phase reaction at the temperatures of 1000 and 1050°C. X-ray diffraction study showed that these compounds are single-phase and have the structure of the Aurivillius phases (AP) family with parameters close to the orthorhombic unit cell corresponding to the space group B2cb (41). The microstructure was studied for all obtained Bi4-xNdxTi3O12 (x=0.1, 0.3, 0.5, 0.7) compositions sintered at temperatures of 1000 °C and 1050 °C. Its analysis also showed that the crystallites are similar one of AP family and characterized with a lamellar-like shape. The relative permittivity ε/ε0 and the dielectric loss tangent tgδ were measured as a function of temperature at frequencies in the range of 100 kHz to 1 MHz.
Влияние режима охлаждения на структуру энтропийно-стабилизированных оксидов (MgNiCoCuZn)O
Authors: Вахрушев С.Б. , Набережнов А.А. , Сумников С.В. , Nallathambi Varatharaja , Kumar Bhaskar Lalith , Kumar Ravi
Published: August 2023

The effect of various cooling regimes on the evolution of the crystal structure of entropy-
stabilized oxides (MgNiCoCuZn)O has been studied using a high-resolution time-of-flight
neutron Fourier diffractometer. It has been established that cooling in a furnace at a rate of 1, 2,
and 5 K/min leads not only to the segragation of a part of copper oxide into a separate phase, but
also to nanostructuring of both the main matrix and CuO. The characteristic sizes of the formed
nanoparticles are determined. It is shown that the expected rhombohedral or tetragonal
distortions due to the possible Jahn-Teller effect are not observed in these samples.
Формирование обменного смещения и анизотропия формы в микрообъектах на основе спиновых клапанов
Authors: Гермизина А.А. , Наумова Л.И. , Миляев М.А. , Заворницын Р.С. , Павлова А.Ю. , Максимова И.К. , Проглядо В.В. , Каменский И.Ю. , Устинов В.В.
Published: August 2023

Rhombus-shaped microobjects formed by strips of two micrometers wide were fabricated from the spin valve film. The influence of the shape anisotropy on the layers magnetic moment rotation during the spin valve magnetic reversal is studied. A method for two-stage thermomagnetic treatment in a direction-fixed magnetic field has been found. The method allows to obtain the opposite sign values of the exchange bias fields in the non-parallel rhombus sides. The direction of the formed exchange bias is determined by the deviation of the strip from the uniaxial anisotropy axis and from the magnetic field applied during thermomagnetic treatment. Based on a rhombus-shaped microobject made from a single spin valve film, the device is a Full Wheatstone bridge. Each side of the rhombus is an active magnetically sensitive element.
Термодинамическое поведение двумерной часовой модели с числом состояний спина q=5
Authors: Муртазаев А.К. , Бадиев М.К. , Магомедов М.А. , Рамазанов М.К.
Published: August 2023

The Monte Carlo method was used to study the thermodynamic properties and phase transitions in a two-dimensional ferromagnetic clock model with q = 5 spin states on a triangular lattice. Systems with linear dimensions L × L = N, L = 24 ÷ 120 are considered. Two maxima are found on the temperature dependence of the heat capacity, which indicate the presence in the model under study of two phase transitions of the Berezinsky-Kosterlitz-Thouless type.
Теплопроводность монокристаллов изотопно-обогащенного германия -=SUP=-70-=/SUP=-Ge, -=SUP=-72-=/SUP=-Ge, -=SUP=-74-=/SUP=-Ge в интервале 80-310 K
Authors: Гибин А.М. , Абросимов Н.В. , Буланов A.Д. , Гавва В.А.
Published: August 2023

The temperature dependence of the thermal conductivity (T) of single crystals isotopically enriched 70Ge (99.926%), 72Ge (99.980%), 74Ge (99.921%) has been measured in the temperature range 80–310K. In the studied temperature range, the thermal conductivity is determined by anharmonic processes of phonon scattering; a decrease in the thermal conductivity with increasing mass of the germanium isotope is experimentally observed.
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Authors: Pereira Stefi
Published: August 2023

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The Influence of Taoism on American Literature, a Study from the Perspective of Western Binary Opposition
Authors: Wen Xiao
Published: August 2023

With the deepening communication between the East and the West. Taoism, a domestic religion in China, has also been introduced into the Western world. In particular the masterpiece of Lao Tzu, Tao Te Ching, has affected numerous readers. There is a huge gap between Western binary opposition and the Eastern philosophy contained in Taoism. Caused by such a mentality, the misunderstanding of American literature on Tao Te Ching and Taoism is ubiquitous. This paper mainly analyzes the introduction and translation of Tao Te Ching in America, the misinterpretation and acceptance of the theory of Lao Tzu and the influence of Taoism on American writers, poets and Chinese-born American writers. Taoism has been greatly promoted and accepted in America with the help of these scholars and works.
Institutions, Complex Societies and Fiscal Policy in Economic Development in Mexico An Objective Study of How These Three Concepts Interrelate with Each other
Authors: Hernández Mauricio Guillermo De Anda
Published: August 2023

We review the main characteristics of three aspects that we consider critical for economic development such as institutions, complex societies and fiscal policy, to conclude that the virtuous coordination of these elements is necessary for economic development of societies and their interaction can explain the situation that Mexico lives today. We end this work stating that it is necessary for the country to develop solid institutions, but at the same time flexible that adapt to the growth of the economy in a globalized world and simplify political systems in order to avoid unnecessary complexities.