bluuebunny/crossref_metadata_2025 huggingface dataset:
Producción de girasol ( Helianthus annuus L.) con aplicación foliar de tierra diatomea
Authors: Raya-Montaño Yurixhi Atenea , Apáez-Barrios Maricela , Lara-Chávez Ma. Blanca Nieves , Apáez-Barrios Patricio
Published: August 2022

En México, en 47% de la superficie de cultivo de girasol (Helianthus annus L.), el rendimiento de grano es menor a 1.0 t ha-1. La tendencia de la agricultura es buscar alternativas de origen natural y amigables con el ambiente para incrementar el rendimiento agrícola. Por esta razón, en este estudio se estableció girasol cv. Victoria aceitero para determinar el efecto de la dosis (0.5, 1 y 1.5%) e intervalo (7, 14 y 21 días) de aplicación foliar de tierra diatomea sobre la producción de materia seca y rendimiento de grano de girasol. El diseño experimental fue de bloques completos al azar, con cuatro repeticiones en arreglo de parcelas divididas. La dosis de 1.0% cada 7 días generó el más alto rendimiento de grano (2,047 kg ha-1), seguido de esta misma dosis cada 14 días (1,715 kg ha-1), lo cual produjo la mayor cantidad de materia seca (1,219 g m-2).
Polimorfismo y letargo en semillas de Suaeda edulis (L.) Flores Olv. & Noguez en condiciones de estrés por NaCl
Authors: Ruiz-Companioni Idael , Noguez-Hernández Roberto , Palacios-Espinosa Alejandro , Ruiz-Espinoza Francisco H. , Beltrán-Morales Alfredo , Murillo-Amador Bernardo
Published: August 2022

Suaeda edulis (L.) Flores Olv. & Noguez es una planta halófita con la capacidad de desarrollarse en ambientes hostiles y presentar polimorfismo, es decir, la capacidad de producir semillas con diferentes características. El objetivo de este estudio fue evaluar la expresión del polimorfismo y la latencia en las semillas de S. edulis, colectadas en cinco zonas del Centro de México que difieren en la salinidad del suelo. El experimento se realizó en casa tipo invernadero, con una temperatura media dentro de la casa sombra durante el periodo de experimentación de 21.63±5.27 °C, con 67.55±16.80% de humedad relativa. Para determinar la capacidad de germinación se utilizó un diseño completamente al azar, cuyos factores en estudio fueron los sitios de colecta (factor 1) con cinco niveles y los tratamientos a las semillas (factor 2) con dos niveles (hidratadas y no hidratadas), para un total de 10 tratamientos con cuatro repeticiones. Se determinaron los tipos de semillas y su capacidad de germinación (número de semillas emergidas por día). Los resultados mostraron que las semillas de S. edulis presentan polimorfismo. Se identificaron semillas sin testa, semillas con testa café y semillas con testa negra. La probabilidad de germinación difiere con respecto a los sitios de colecta y tratamientos de semillas hidratadas y no hidratadas. La probabilidad de germinación mayor se logró con las semillas hidratadas del sitio tres, con valor cercano a 70% y con diferencia significativas (p<0.05) respecto a semillas del mismo sitio no hidratadas y respecto a las semillas de los otros sitios. Las semillas presentan letargo, que puede restablecerse al someterlas a periodos de imbibición en agua destilada, lo cual posibilita que recuperen la capacidad de germinar, y permite un porcentaje de germinación mayor. Los resultados demuestran que al hidratar (48 h) las semillas se logra una germinación mayor.
TECNOLOGIAS CUIDATIVO-EDUCACIONAL COMO AUXILIO AOS CUIDADORESDE IDOSOS
Authors: Pereira da Silva Dias Filipe , Ferraz Queiroga Freitas Fabiana
Published: August 2022

Objetivo: analisar a produção científica que aborda as tecnologias cuidativo-educacional destinadas aos cuidadores de idosos. Método: trata-se de uma revisão integrativa da literatura. Após busca nas bases de dados, com aplicação de filtros e refinamento dos achados, foram selecionados seis artigos para compor a amostra deste estudo. Resultado: Os estudos evidenciaram que as tecnologias cuidativo-educacional podem se apresentar em três grupos distintos: materiais impressos, digitais e as relações interpessoais. Trabalham assuntos específicos e abrangentes, que contribuem, favoravelmente, com o conhecimento teórico e prático dos cuidadores de idosos, da comunidade e dos profissionais. Considerações finais: apesar da relevância da temática, percebe-se um baixo quantitativo de artigos relacionados às tecnologias cuidativo-educacional voltadas para os cuidadores de idosos. Compreende-se que o desenvolvimento de mais estudos que possam criar e validar tecnologias que possibilitem promoção do cuidado em saúde e qualidade de vida para idosos e seus cuidadores é importante à transformação do processo saúde doença.
Data-driven personalized medicine approaches to cognitive-behavioral therapy allocation in a large sample: A reanalysis of the ENRICHED study
Authors: van Bronswijk Suzanne Catharina , Howard Jacqueline , Lorenzo-Luaces Lorenzo
Published: August 2022

Background: Although effective treatments for common mental health problems are available, individual responses to these treatments are heterogeneous and difficult to predict. Treatment efficacy can be optimized by targeting interventions using individual predictions of differential treatment outcomes. The aim of this study was to develop and test a multivariable prediction algorithm with machine learning techniques using data from one of the largest randomized clinical trials on psychological interventions for common mental health problems.Methods: This is a secondary analysis of the Enhancing Recovery in Coronary Heart Disease study, which investigated the effectiveness of six months of cognitive behavioral therapy (CBT) and care as usual (CAU) for depression and low perceived social support following an acute myocardial infarction. 2481 participants were randomly assigned to CBT and CAU. Baseline sociodemographics, depression characteristics, comorbid symptoms, and stress and adversity measures were used to build an algorithm to predict post-treatment depression severity. Performance and generalizability of the prediction algorithm were tested in a held-out sample. This study is registered http://clinicaltrial.gov/ct2/show/NCT00000557, The clinical Trials.gov Identifier: NCT00000557.Results: Treatment matching based on predictions in the testing sample resulted in small effects, that were more pronounced for individuals matched to CBT. We identified a subgroup of individuals for which CBT did not appear more efficacious than CAU. Conclusions: These small matching effects are likely a realistic representation of the performance and generalizability of multivariable prediction algorithms based on clinical measures. These results indicate that future work and new approaches are needed.
Fabrication and characterization of TiO2 dye sensitized solar cells
Authors: S. Baron Aref , Abbas Ghufran Mufeed
Published: August 2022

Thin films of TiO2 nanostructures were prepared on FTO bases with different temperatures (140,160) for 4 h. The XRD results showed that in the prepared (quadrangular) samples an increase in the intensity of the peaks and a decrease in the width of the FWHM was observed due to the increase in temperature as well as an increase in the grain size in which the distance between the grains decreased. Through the UV-Vis results, the energy band gap Eg was calculated from the reflectivity spectrum using the Kobelka - Monk equation. The increase in temperature reduced the energy band gap, which shifting it towards the blue direction. FESEM, an increase in the surface thickness of the thin film due to an increase in the preparation temperature. The solar cell efficiency was decreased with increased in temperature.  Where it was found the efficiency reduce from 0.17% to 0.004%  for As for 140 ° C and 160 ° C respectively
भाषाविज्ञान अध्ययन : एडवार्ड सपिरया सिद्धान्त
Authors: महर्जन Maharjan दीपा Dipa
Published: August 2022

मनू सामाजिक प्राणी खः । समाजय्‌ थःथवं विचार, भाव, इच्छा व्यक्त याय्‌गु निंतिं भाषाया विकास जुल । उकिं मनूतय्‌ दथुइ जुइगु अर्थपूर्ण संचार हे भाषा खः । अले थ्व हे भाषाया वैज्ञानिक अध्ययन हे भाषाविज्ञान खः । मनूया जीवनय्‌ भाषा छगू प्राकृतिक व सामान्य अंगकथं नालाच्वंगु दु । संसारया फुक्क भाषाया लेखन अभ्यास मदु । गुलि भाषा ला सम्बन्धित समाजया मनूतय्‌सं नोंवाइगु ध्वनि, खँगोः आदिया आधारय्‌ जक ल्यं दु । भाषाया छाय्‌ लेखन शैली मदुगु ?, ध्वनि व लेखन दथुइया सम्बन्ध, भाषिक संचार आदिया विषयसं भाषाशास्त्री एवं मानवशास्त्री एडवार्ड सपिरं व्याख्या यानादी । वय्‌कलं भाषाविज्ञान व मानवशास्त्रया अन्तरसम्बन्धया विषयसं अध्ययन यानादी । सपिरं भाषायात विशुद्ध मानवीय व मानवीय भाव, विचार, इच्छा स्वतन्त्र रूपं संचार याय्‌गु असहज वा अस्वाभाविक प्रतीकात्मक प्रणालीकथं परिभाषित यानादी । अथे हे, भाषा व संस्कृतिया सम्बन्धयात नं सपिरं विशेष महत्व बियादी । संस्कृतिं भाषाया आकृति निश्चित याइगु मखुसें संस्कृतियात निश्चित रूप बीगु ज्या भाषां याइ ।
The impact of the COVID-19 pandemic on the social work client base
Authors: Bastaits Kim , Pasteels Inge , Massart Michiel , Put Bart
Published: August 2022

The COVID-19 pandemic has rampaged through the daily life of individuals, increasing existing vulnerabilities and bringing about new ones. Social service workers act in close proximity and connection with these vulnerable groups, and measures taken to decrease the COVID-19 contamination rate — such as working from home, reducing social contacts and most of all lockdowns — negatively affect the core tasks of social service workers. Consequently, these professionals have had to find other ways to reach out to clients. This may potentially change the type of clients who have been reached and prioritized during the pandemic. Moreover, the profile of clients may have changed due to the pandemic. With this study, we address three research questions: (1) Which clients were prioritized by social service workers?, (2) Which clients were not able to be reached by social service workers?; and (3) Do social service workers expect a new vulnerable client base to emerge as a consequence of the COVID-19 pandemic?
To help answer these questions, we used data from the Social Work COVID-19 Survey, obtained from 2,815 social service workers and collected in April and May 2020 during the first Belgian lockdown. The results indicate that urgent cases in need of essential, vital care were prioritized, with social service workers relying more on their gut instincts than on the customary procedures. Second, clients who could not be reached were those with limited access to modern communications, or with lower levels of digital skills. This often coincides with more vulnerable groups (such as people with mental health issues, financial issues, a small social network, the homeless and the elderly). Third, with regard to possible new clients, social service workers anticipate a ‘less standard’ and ‘more temporary’ client base, with more ‘middle-class families’ who have become vulnerable due to the economic consequences of the COVID-19 pandemic. Moreover, social service workers expect the pressure in the private life of individuals to increase, and have observed several mental health consequences of the COVID-19 pandemic.
Ebook Preview: STEM-in-SEM Imaging Techniques for Microelectronics Failure Analysis
Authors: Holm Jason D. , Caplins Benjamin W.
Published: August 2022

This article describes an ebook titled STEM-in-SEM: Introduction to Scanning Transmission Electron Microscopy for Microelectronics Failure Analysis, intended as an introductory tutorial for those with little or no transmission imaging experience and as a source of ideas for SEM users looking to expand the imaging and diffraction capabilities of their equipment.
Combined SCM and Nanoprobing Study of Resistive Fails on SOI FinFET Devices
Authors: Teague Sheridan Lucile C. , Nedeau Don
Published: August 2022

Scanning capacitance microscopy (SCM) and nanoprobing are key tools for isolating and understanding transistor level fails. In this case study, SCM and nanoprobing are used to determine the electrical characteristics of cluster-type failures in 14 nm SOI FinFET SRAM after standard FIB cross-section imaging failed to reveal any visible defects.
Failure Analysis, Statistical Risk Assessment, and Advanced Modeling in a Structured Problem Solving Approach: Case Study for a Delamination Defect in the Automotive Semiconductor Industry
Authors: Bergès Corinne
Published: August 2022

Failure analysis is the study and presentation of observable or measurable phenomena. Risk assessment, on the other hand, is when root causes are studied to predict the potential for future failures. In this article, the author describes a structured problem-solving approach that consists of failure analysis, risk assessment, and advanced modeling. A case study is also presented in which the probability of future failures, due to a delamination defect, is determined based on field returns.
SAM Theory and Case Studies in Reliability and Counterfeit Detection
Authors: Whitney Eric
Published: August 2022

This article reviews the basic principles of scanning acoustic microscopy (SAM) and presents several case studies demonstrating its use in failure analysis and counterfeit detection. The FA case studies show how SAM is used to detect delamination, cracking, and manufacturing defects in ceramic chip capacitors and resistors, voids in a full-bridge rectifier, and a radiation-induced defect in a microprocessor. In cases involving counterfeit ICs, CSAM images reveal the presence of an abnormality on component packages, evidence of relabeling, and popcorn fractures indicative of the use of excessive heat and force to dislodge components from circuit board assemblies.
Quantum Computing Is Still in Basic Research Phase
Authors: Teich Paul
Published: August 2022

This column assesses the near-term challenges associated with quantum computing, noting that 15 years is an optimistic estimate for commercially viable quantum cloud computing. In the midst of the struggle, however, there is also opportunity, particularly in metrology and component development.
Failure Analysis from a Customer Point of View
Authors: Kolasa Ted
Published: August 2022

This column addresses the different perspectives of providers and customers of semiconductor failure analysis laboratories. The columnist, after having seen both sides of the electronics industry, as a supplier and customer, sheds light on how the two sides interact when entangled with reliability issues and failures.
Evaluation of a Co-Simulation Approach for Functional Verification of Analog and Mixed Signal Devices
Authors: Heitauer Mathias , Versen Martin
Published: August 2022

This article presents an automation workflow for the development of analog and mixed-signal devices similar to the two-stage process used for the design and verification of logic ICs. The use of a co-simulation interface makes it possible to build and verify failure models.
A Sample Preparation Workflow for Delayering a 45 nm Node Serial Peripheral Interface Module
Authors: Patel Yash , Baur Joshua , Scholl Jonathan , Waite Adam R. , Kimura Adam , Kelley John , Ott Richard , Via Glen David
Published: August 2022

Further development of SEM-based feature extraction tools for design validation and failure analysis is contingent on reliable sample preparation methods. This article describes how a delayering framework for 130 nm technology was adapted and used on a 45 nm SPI module consisting of 11 metal layers, 10 via layers, two layers of polysilicon, and an active silicon layer. It explains how different polishing and etching methods are used to expose each layer with sufficient contrast for SEM imaging and subsequent feature extraction. By combining polygon sets representing each layer, the full design of the device was reconstructed as shown in one of the images.
Methods to Enable Fault Isolation on 2.5D Molded Interposer Packages
Authors: Hunt Douglas , Bader Daniel , Limbecker Pascal , Barth Heiko
Published: August 2022

This article discusses the failure analysis challenges associated with large overmolded 2.5D packages and explains how laser decapsulation followed by microwave-induced plasma (MIP) spot etching removes overmold while keeping everything else intact. It also describes a defect isolation procedure in which the sample is analyzed in a large chamber environmental SEM with its ball grid array directly wired to an EBAC amplifier.
A Brief Overview of Scanning Transmission Electron Microscopy in a Scanning Electron Microscope
Authors: Holm Jason
Published: August 2022

This article provides a brief overview of STEM-in-SEM, discussing the pros and cons, recent advancements in detector technology, and the emergence of 4D STEM-in-SEM, a relatively new method that uses diffraction patterns recorded at different raster positions to enhance images offline in selected regions of interest.
Failure Modes in Microfabricated Ion Trap Devices for Quantum Information Science
Authors: Blain Matthew G. , Haltli Raymond A. , Revelle Melissa
Published: August 2022

Trapped ion systems are one of the leading technology platforms for quantum computing. This article describes the construction and operation of ion trap devices and the various modes of failure that have been observed. Examples of failure in either the rendering or use of packaged trap chips are presented, including electrode shorts and opens, detached bond wires, and RF breakdown damage.
Nanoprobing at Low Beam Energy, Addressing Current and Future Nodes
Authors: Rummel Andreas , Smith Andrew Jonathan
Published: August 2022

This article discusses the challenges associated with nanoprobing advanced technology node devices and explains how to optimize SEM images for beam voltages of 100 eV or less.
Physical Security Roadmap for Heterogeneous Integration Technology
Authors: Khan Aslam A. , Xi Chengji , Asadizanjani Navid
Published: August 2022

Interposers play an important role in 2.5D and 3D packages, routing power and communication signals between dies while maintaining electrical contact with I/O pins. This role and their relatively simple construction makes interposers a target for malicious attacks. In this article, the authors assess the vulnerabilities inherent in the fabrication of interposers and describe various types of optical attacks along with practical countermeasures.
اتجاهات الرأي العام الجزائري تجاه الحراك الشعبي
Authors: هوادف عبد الله
Published: August 2022

أظهرت بيانات المؤشر العربي 2019 - 2020 الخاصة بالحراك الشعبي في الجزائر ترسخ ظاهرة الخروج إلى الشارع للاحتجاج كشكل مهيمن من أجل التعبير عن المطالب السياسية والاقتصادية والاجتماعية، في الوقت الذي تراجعت فيه صور المشاركة السياسية المؤسسية، مثل الانتظام في الأحزاب والنقابات. وأكدت نتائج المؤشر أن الاستبداد والاستئثار بالحكم والفساد هي أكبر العوامل التي دفعت الناس إلى الاحتجاج، وأعطت الحراكَ الزخم الكبير الذي ميزه. وعلى الرغم من نجاح حراك الشارع الجزائري في إرغام بوتفليقة على الاستقالة، ومنعه من الترشح لعهدة رئاسية خامسة، وارتفاع مستوى الآمال في تحقيق تحسن في المؤشرات الاقتصادية والاجتماعية، فإنّ تلك الآمال سرعان ما تراجعت بعد تنامي اعتقاد مفاده أن النظام لم يتغير، وأن الأوضاع العامة ظلت مثلما كانت عليه من قبل.
سياسة الجزائر الأمنية: تحوّلات ومعضلات في سياق القلاقل إقليميًا والحراك داخليًا
Authors: بن عنتر عبد النور
Published: August 2022

تتناول هذه الدراسة سياسة الجزائر الأمنية عمومًا وعقيدتها الأمنية خصوصًا، محلّلةً تحولاتها ومعضلاتها في بيئة إقليمية مضطربة وفي سياق حراك شعبي داخليًا. وتحاجّ بأن ثمة تعديلات طفيفة طرأت عليهما تكيفًا مع مقتضيات أمنية إقليمية، مستبعدة أي تغير جوهري في الراهن. كما تحاجّ بأن التوتر بين المستلزم الأخلاقي/ المعياري والمستلزم الأمني من جهة، ومبدأ عدم التدخل المزدوج )السياسي والعسكري( من جهة أخرى يمث ان معضلتَين أساسيتَين تواجههما سياسة الجزائر الأمنيةوعقيدتها. وعلى أساس هذين العنصرين تبحث الدراسة، بعد تأصيل مفهومَين للموضوع، في سياسة الجزائر وعقيدتها وتحولاتها. ثم تتوقف عند قرار دسترة مشاركة القوات الجزائرية في عمليات حفظ السلام الدولية محللة سياقَيه )المحلي والخارجي( ودوافعه ومسوَّغاته، والمحاذير المترتبة عليه. وتحلل استراتيجية الجزائر الأمنية إقليميًا، والتي تطرحها بديلًا للتدخل. وتوصلت الدراسة إلى ثلاثة استنتاجات أساسية. أولاً، ثمة تكيف محدود مع مسألة التدخل الخارجي وفقًا لمقتضيات المصلحة الأمنية. ثانيًا، نهاية الرفض المطلق لنشر القوات خارج الحدود. ثالثًا، ترجيح احتدام التوتر بين الاعتبارات الأخلاقية/ المعيارية والأمنية في حال استمرار الاضطرابات في تخومها الجغرافيّة.
Giftedness and peer group: an exploration of the representational repertory on giftedness in the early school age
Authors: Baccassino Francesca , Pinnelli Stefania
Published: August 2022

There has been growing interest in the issue of giftedness and in educational paths which can counteract the development of misrepresentations and negative attitudes on the theme. These forms of common sense contribute to interpreting social reality using shortcuts in thinking that are sometimes inadequate to explain the complexity of human personality and that, therefore, may generate some stereotypes and prejudices. The analysis and orientation of distorted representations could prompt the activation of inclusive behaviour towards gifted peers. This contribution therefore focuses on the representations concerning giftedness in the peer group. The project, carried out with pupils of primary school class, aims to explore the representations and attitudes of children exposed to a path of awareness on giftedness in order to support a correct and inclusive representation of the phenomenon.
Ein Jahr Fluchtreise Und Emigration: Ein anonymer royalistischer ’récit de voyage‘ von 1790
Authors: Rieger Dietmar
Published: August 2022

Depuis toujours, le genre du récit de voyage littéraire en France se distingue par son carac- tère essentiellement ouvert. Une de ses variantes est le récit de voyage de tendance autobiographique, rapporté par un ’je‘ auteur-narrateur,
en même temps protagoniste, et relatant des expériences de voyage prétendument authentiques de l'auteur ou d'autres personnes, en tout cas plus ou moins fictionnalisées. Au centre de cet article se trouve l'analyse du Voyage d'une Française en Suisse et
en Franche-Comté depuis la Révolution, publié en 1790 sous forme anonyme et attribué à une certaine Madame de Gauthier, auteure de voyage fermement royaliste. Ce récit sous forme épistolaire monologique montre que ce genre variable est en
principe soumis aussi aux événements cruciaux de l'histoire – dans ce cas la première phase de la Révolution française. Ainsi n'est- on pas étonné de voir que, sans sacrifier pour autant sa fonction réelle de guide, ce Voyage
se transforme en récit d'un voyage-fuite et quelques mois plus tard d'un voyage-émigration, tout en marquant ainsi le début de toute une série de ’romans d'émigration‘ de la fin du XVIII e siècle. L'action de ce ’roman d'émigré‘
particulier de 1790 est le voyage, raconté par elle-même, d'une protagoniste accompagnée de son groupe, voyage oscillant entre fictionnalité et réalité autobiographique et souvent enrichi des aventures d'autres personnes. Elle ne se limite pas à
la reproduction du mouvement des voyageurs et de ce que ceux-ci voient et éprouvent en visitant, d'une station à l'autre, les différents paysages, villes, institutions et particuliers et en apprenant leur histoire, mais il s'agit d'un mouvement dont l'itinéraire
lui-même est déterminé par les forces inéluctables de l'histoire.
MODEL KUALITAS HIDUP PASIEN GAGAL GINJAL TERMINAL YANG MENJALANI HEMODIALISIS DI RSUD RATU ZALEHA MARTAPURA
Authors: Rachmadi Agus , Rizani Akhmad , Rahmilah Rahmilah , Kirana Rita
Published: August 2022

Penyakit Ginjal Kronik Tahap Terminal (End Stage Renal Disease atau ESRD) adalah merupakan masalah kesehatan masyarakat di seluruh dunia termasuk Indonesia, ginjal mengalamai kerusakan bersifat menetap dan fungsinya sangat berkurang sehingga memerlukan terapi pengganti ginjal ; hemodialisis..

            Prevalensi gagal ginjal kronis di Indonesia 0,2%.Insiden rate penderita gagal ginjal tahun 2006 sebesar 30,7 % dan menurut WHO (1999) diperkirakan akan terus meningkat antara tahun 1995-2025 sebesar 414 %. Tahun 2011 di Indonesia terdapat 15353 pasien menjalani hemodialisis dan tahun 2012 bertambah sebanyak 4268 orang (IRR,2013)

            Hemodialisis merupakan terapi pengganti ginjal bertujuan mengoreksi keseimbanan air dan elektrolit serta membuang sisa-sia metabolism, terapi hemodialisis menyebabkan ketergantungan pasien secara fisik, psikis bahkan sosial-ekonomi yang dapat berpengaruh pada kualitas hidup pasien.

            Penelitian ini bertujuan menyusun sebuah model statistik yang memprediksi kualitas hidup pasien ESDR dengan terapi hemodialisis berdasarkan variabel usia, lamanya menjalani terapi hemodialisis, IDWG dan jumlah penyakit komplikasi penyerta.          

           Metode; desain yang digunakan yaitu korelasi dengan pendekatan cross sectional, dengan teknik pengambilan sampel ; purposive sampling, sebanyak 49 pasien menjalani terapi hemodialisa di ruang hemodialisa RSUD Ratu Zaleha Martapura.

           Analisis data dengan distribusi frekuensi (univariat), Pearson correlation (bivariat) dan regresi linier (multivariate) dengan taraf signifikan α 0,05.

Hasil penelitian ada hubungan antara IDWG dengan kualitas hidup pasien yang menjalani terapi hemdoialisis dan didapatkan model fit antara usia, lamanya menjalani terapi hemodialisis, IDWG dan jumlah penyakit komplikasi penyerta dengan kualitas hidup pasien.

Saran ; lebih mencermati IDWG yang merugikan, karena faktor yang paling dominan mempengaruhi kualitas hidup pasien.
AKIBAT PERKAWINAN “SIRI” MENURUT UU NO 1 TAHUN 1974 SEBAGAIMANA YANG TELAH DIUBAH MENJADI UU NO 16 TAHUN 2019
Authors: Ghalih Ghalih Wahyu Setiyadi , Sumarwoto  , Putri Maha Dewi
Published: August 2022

Tujuan penelitian ini adalah: perkawinan siri merupakan perkawinan yang dilangsungkan dengan dua orang saksi dan wali serta adanya ijab qobul.Penelitian ini bertujuan untuk mengetahui alasan melakukan perkawinan siri yang dapat menimbulkan akibat yang ditimbulkan dari perkawinan siri tersebut, dan solusi untuk istri dan anak untuk mendapatkan hak-hak yang ditimbulkan akibat perkawinan siri. Dalam penelitian ini, jenis penelitian yang akan digunakan oleh penulis yaitu penelitian hukum empiris. Dalam hal ini, penelitian hukum empiris digunakan untuk mengumpulkan data yang berada dilapangan. Data yang digunakan adalah data primer dan data sekunder. Tehnik pengumpulan data menggunakan tehnik observasi, tehnik wawancara dan dokumentasi. Adapun analisis data menggunakan model analisis interaktif. Hasil penelitian dapat disimpulkan bahwa perkawinan adalah suatu kesatuan yang melahirkan suatu keluarga sebagai aspek kehidupan bermasyarakat dan bernegara, yang diatur oleh hukum tertulis (hukum negara) dan hukum adat.Undang-undang negara yang mengatur perkawinan adalah Undang-Undang Perkawinan Nomor 1 Tahun 1974 sebagaimana yang dirubah menjadi UU No. 16 Tahun 2019. Di sisi lain, aturan adat tidak tertulis yang mengatur perkawinan sejak zaman nenek moyang sampai sekarang tetap tidak berubah.Perkawinan siri di bawah tangan tentang hukum Islam dan UU No. 1 Tahun 1974 sebagaimana yang dirubah menjadi UU No 16 Tahun 2019, masyarakat memiliki dua penafsiran tentang hakikat nikah siri. Pertama, nikah siri didefinisikan sebagai akad nikah yang tidak dicatatkan pada otoritas pencatatan nikah; namun syarat dan rukunnya sesuai dengan syariat Islam. Kedua, perkawinan yang tidak dicatatkan adalah perkawinan yang dilakukan tanpa persetujuan wali yang sah dari wanita tersebut.
Procjena potencijalne darovitosti u prirodoslovnom području kao alat za unaprjeđenje pristupa poučavanja darovitih učenika
Authors: Vrbanović Dorotea , Šimić Šašić Slavica , Radanović Ines
Published: August 2022

Darovitost je kao pojam, unatoč brojnim spoznajama, još uvijek nedovoljno određena za potrebe obrazovanja te su za nastavnike i stručne suradnike odgoj i obrazovanje takve djece još uvijek vrlo složeni i izazovni zadaci. Do sredine 1990-ih godina vladalo je uvjerenje da točnost i pouzdanost učitelja u procjeni darovitosti nije značajna, no važnu ulogu u točnosti procjena ima upravo instrument koji učitelj koristi. Također, učitelji donose visoko subjektivne procjene ako nemaju podršku u kriterijima i skalama koje ih točno vode prema karakteristikama koje trebaju opažati za procjenu darovitosti i osiguravaju manji utjecaj subjektivnosti na rezultat. U okviru HRZZ projekta „Učenje biologije u epidemiološki prilagođenom istraživačkom okruženju“ prilagođene su skale za procjenu potencijalne darovitosti (u prirodoslovnom području) s ciljem prilagodbe odgojno-obrazovnog procesa potrebama darovitih učenika. Teorijska podloga za izradu skala za procjenu darovitosti bio je Renzullijev troprstenasti model darovitosti koji uključuje iznadprosječno razvijene opće ili specifične sposobnosti, osobine ličnosti, posebice specifičnu motivaciju za rad (predanost zadatku) i kreativnost. Skale se sastoji od niza pozitivno formuliranih tvrdnji raspoređenih u određeni broj subskala koje ispituju različite osobine darovitih učenika. Oni učenici koji pripadaju u gornjih 25 % od ukupnog rezultata za sve tri skale (opće ili specifične sposobnosti, motivacije i kreativnosti) smatrat će se potencijalno darovitima. Skala za procjenu učenika, uz standardne testove koje provode psiholozi, može biti izvrstan alat nastavnicima za identifikaciju darovitih učenika u razredu na temelju koje će unaprijediti svoj nastavni proces prema specifičnim zahtjevima pojedinih učenika.
Aplikasi Komputasi Bayesian Regresi Dummy Pada Kasus Kanker Serviks di Kabupaten Tuban
Authors: Mahmudah Nur , Yuwita Pelangi Eka
Published: August 2022

Kanker serviks adalah kanker yang paling banyak diderita oleh wanita yang menjadi penyebab kematian. Penyebab utama kanker serviks adalah infeksi Human Papilloma Virus (HPV). Kanker serviks merupakan penyakit yang disebabkan oleh pertumbuhan sel- sel jaringan tubuh yang tidak normal di dalam leher rahim/ serviks yang terdapat dalam organ bagian reproduksi pada tubuh wanita dan menyebabkan kematian. Untuk mencegah munculnya fase ganas dibutuhkan program screening pada lama rawat inap pasien kanker serviks. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi lama rawat inap pasien kanker serviks di Kabupaten Tuban dengan metode komputasi Bayesian Regresi Dummy. Metode Bayesian adalah salah satu teknik komputasi pada estimasi parameter yang menggabungkan fungsi likelihood dan distribusi prior menjadi distribusi posterior dalam menduga parameter model. Bayesian regresi dummy menghasilkan suatu variabel yang memiliki pengaruh signifikan terhadap lama rawat inap pasien kanker serviks, yaitu variabel Komplikasi (X1). Dengan nilai alpha 2.17, menunjukan bahwa terdapat dependensi/error yang tidak bisa dijelaskan dalam model regresi dummy pada kasus lama rawat inap kanker serviks di Kabupaten Tuban.
Las Transformaciones de los Espacios Rurales Argentinos: Paisajes Imaginados y Cambios Socio Ambientales (1880-1930)
Authors: França Ana Marcela , Cerdá Juan Manuel , Muzlera José
Published: August 2022

El presente trabajo analiza el proceso de transformación del ambiente en dos espacios diferentes de la Argentina: las provincias de Buenos Aires y Mendoza. En este trabajo, se sostiene que los cambios del medio biofísico son provocados por las acciones de los seres humanos a partir de los imaginarios y las concepciones que reorganizan las relaciones sociales. Desde este punto de vista, el ambiente natural es, además de sus condiciones físicas y ecológicas, una construcción social simbólica de una época. Así, entre finales del siglo XIX y comienzos del siglo XX, el ideario hegemónico de la sociedad argentina estuvo dominado por la idea de “modernidad”. Con el fin de analizar esta evolución se analizarán fuentes bibliográficas, datos estadísticos e imágenes.
Bonanza o Falsas Riquezas: Cambiantes Imaginarios Mexicanos del Trópico y el Impulso Civilizatorio
Authors: Vitz Matthew
Published: August 2022

Existing scholarship on “tropicality” emphasizes how Europeans and US-Americans constructed the tropics discursively and visually in the eighteenth and nineteenth centuries. Scientists, investors, and travelers denigrated tropical spaces to legitimize imperialism, labeling them backwards, racially degenerative, disease-ridden, and unconducive to civilization without white European intervention These works unwittingly reproduce a central assumption of the very imperialists they critique: namely, that North Atlantic elites controlled knowledge production. They thus marginalize the important theorizing and conceptualizing that transpired in tropical spaces. Following independence, Latin American national elites agonized over how to integrate their tropical territories, many of which remained isolated, and make them legible for economic modernization. This article uses Mexico as a case study for Latin American representations about the tropics given its diverse temperate and tropical geography, its key role in the global commercial economy, and its robust intellectual production. I argue that the ways in which Mexican intellectuals—public officials, geographers, philosophers, and others—thought about their low-lying tropical lands molded nation-building projects and contributed to the global production of environmental knowledge at a time when notions of tropical peril and degeneracy were giving way to the promise of tropical bonanza. By tracing the changes and continuities of Mexicans’ tropical discourses in a global context, I underscore the underappreciated environmental and geographic thought of influential Mexicans—from Matías Romero and Francisco Bulnes to José Vasconcelos—who rarely appear in environmental historiography. A focus on these different imaginaries regarding the significance, purpose, and place of Mexico’s tropical lands also reveals the extent to which material interventions in the tropics and discursive representations of the tropics have co-constituted each other.
ON THE ESTABLISHMENT OF THE POSITION OF OMBUDSMAN FOR THE PROTECTION OF HUMAN RIGHTS WHEN USING INFORMATION TECHNOLOGIES IN RUSSIA
Authors: Мочалов Артур Николаевич
Published: August 2022

The article argues for the need to introduce the position of specialized ombudsman in the Russian Federation, whose competence will include the protection of human rights in the digital space, including the Internet. Purpose: to formulate and substantiate proposals for the establishment of the position of ombudsman for the protection of human rights in the field of information and telecommunication technologies. Methods: the research is based on the comparative legal method. The author analyzes the experience of foreign countries – Australia, Canada, Belgium, New Zealand, where independent state institutions operate to protect the rights of individuals when using information technologies, including the right to information and the right to privacy. The method of interpretation of legal norms and provisions of strategic documents of the Russian Federation is also applied. Results: analyzing Russian practice, the author concludes that federal executive authorities, in particular Roskomnadzor (Federal Service for Supervision of Communications, Information Technology and Mass Media), whose functions include the protection of the rights of subjects of personal data, cannot be considered as analogous human rights institutions. They are not independent and, therefore, cannot take sufficient action if other government agencies act as violators. For this reason, it is concluded that it is advisable to establish a specialized ombudsman.
THE DEVELOPMENT OF ENVIRONMENTAL COOPERATION BETWEEN THE RUSSIAN FEDERATION AND THE EUROPEAN UNION BASED ON THE PARTNERSHIP AND COOPERATION AGREEMENT AND THE ROAD MAP ON THE COMMON ECONOMIC SPACE
Authors: Mukhametgareeva Natalya , Yusupova Zylia
Published: August 2022

The Russian Federation and the European Union have urgent environmental issues that can be solved only by joint efforts. Russia actively works in cooperation with individual European countries and the European Union in this regard. The partnership between Russia and the European Union in the sphere of ecology is supported by the Partnership and Cooperation Agreement and the Road Map on the common economic space. The completion of such a treaty is very significant not only for the under question countries but for the whole continent.
APLIKASI E-COMMERCE BERBASIS ANDROID DI PT MARAWSI ALMADINAH RAYA
Authors: Fauzidwiseptiawan  , Fatimah Fety , Jaenudin Jejen
Published: August 2022

Tren perdagangan onliene melalui mobile device yang marak terjadi tentu menjadi peluang bisnis yang menguntungkan bagi para pelaku bisnis untuk semakin memperkuat bisnis, mempertahankan pelanggan mereka dengan memberikan berbagai kemudahan salah satunya yakni dengan menyediakan aplikasi mobile commerce. Pada Penelitian ini dilakukan perancangan dan pembangunan aplikasi berbasis mobile serta pengujian dengan menggunakan metode black box. Metode ini diimplementasikan ke dalam sebuah aplikasi e-commerce berbasis android di PT Marawis Almadinah Raya. Pengumpulan datanya menggunakan observasi dan wawancara. Kemudian data diimplementasikan untuk dapat diaplikasikan pada aplikasi mobile. Pengimplementasian aplikasi berbasis mobile ini dirancangan menggunakan Bahasa pemrograman kotlin dengan aplikasi pendukung android studio versi 4.1.2. Aplikasi e-commerce ini dapat mempermudah pelanggan/pembeli untuk memesan barang dari PT Marawis Almadinah Raya dimana saja melalui smartphone yang telah menjadi gaya hidup di zaman sekarang.

Kata kunci : Teknologi Informasi, Mobile Android, Black box, Kotlin
The epitranscriptome of Vero cells infected with SARS-CoV-2 assessed by direct RNA sequencing reveals m6A pattern changes and DRACH motif biases in viral and cellular RNAs
Authors: Campos João H. C. , Alves Gustavo V. , Maricato Juliana T. , Braconi Carla T. , Antoneli Fernando M. , Janini Luiz Mario R. , Briones Marcelo R. S.
Published: August 2022

The epitranscriptomics of the SARS-CoV-2 infected cell reveals its response to viral replication. Among various types of RNA nucleotide modifications, the m6A is the most common and is involved in several crucial processes of RNA intracellular location, maturation, half-life and translatability. This epitranscriptome contains a mixture of viral RNAs and cellular transcripts. In a previous study we presented the analysis of the SARS-CoV-2 RNA m6A methylation based on direct RNA sequencing and characterized DRACH motif mutations in different viral lineages. Here we present the analysis of the m6A transcript methylation of Vero cells (derived from African Green Monkeys) and Calu-3 cells (human) upon infection by SARS-CoV-2 using direct RNA sequencing data. Analysis of these data by nonparametric statistics and two computational methods (m6anet and EpiNano) show that m6A levels are higher in RNAs of infected cells. Functional enrichment analysis reveals increased m6A methylation of transcripts involved in translation, peptide and amine metabolism. This analysis allowed the identification of differentially methylated transcripts and m6A unique sites in the infected cell transcripts. Results here presented indicate that the cell response to viral infection not only changes the levels of mRNAs, as previously shown, but also its epitranscriptional pattern. Also, transcriptome-wide analysis shows strong nucleotide biases in DRACH motifs of cellular transcripts, both in Vero and Calu-3 cells, which use the signature GGACU whereas in viral RNAs the signature is GAACU. We hypothesize that the differences of DRACH motif biases, might force the convergent evolution of the viral genome resulting in better adaptation to target sequence preferences of writer, reader and eraser enzymes. To our knowledge, this is the first report on m6A epitranscriptome of the SARS-CoV-2 infected Vero cells by direct RNA sequencing, which is the sensu stricto RNA-seq.
Multisource data integration for targeted bus exterior advertising
Authors: Huang Meng , Li Xinchi , Tu Wei , Yang Mingchuan
Published: August 2022

Bus exterior advertising plays a significant role in outdoor advertising, since it provides frequent exposure to a large number of residents. Traditional route selection methods are generally based on a rough estimation, for example, the number of total passengers of a bus route or the geographical features along the bus route. Targeted bus exterior advertising remains a challenge as little is known about the characteristics of the people along the bus route. In this study, we are aiming at determining a set of bus routes for a given ad category to maximize advertising effectiveness, by mining multiple data sources, including mobile phone data, bus GPS data, smart card data (SCD), and land use data. Specifically, we first estimated the distribution of potential target audiences using mobile phone data and land use data. Two optimization models are proposed considering different advertising requirements. For well-established brands that audiences are familiar with, a wide coverage-oriented bus route selection model is proposed to maximize the coverage of potential target audiences. For new brands that require a high level of exposure before they become recognizable, a deep coverage-oriented bus route selection model is proposed to maximize the total exposure times of the ads. Both models were demonstrated with a case study in Shenzhen, China to explicitly present the outcomes of the models and the differences between them. The calculation results show that the wide coverage-oriented model achieves an average of 84.8% improvement compared with baseline 1 which selects the bus routes with the most passengers, while an average of 9.2% improvement compared with baseline 2 which selects the bus route with the maximum coverage of the target area in reaching more potential target audiences. The exposure intensity of the deep coverage-oriented model is almost 3.7 times of the wide coverage-oriented model. The proposed models provide new options for advertisers to select a suitable advertising strategy according to their needs.
COVID-19 in pediatrics: Genetic susceptibility
Authors: Glessner Joseph T. , Chang Xiao , Mentch Frank , Qu Huiqi , Abrams Debra J. , Thomas Alexandria , Sleiman Patrick M. A. , Hakonarson Hakon
Published: August 2022

The uptick in SARS-CoV-2 infection has resulted in a worldwide COVID-19 pandemic, which has created troublesome health and economic problems. We performed case–control meta-analyses in both African and European ethnicity COVID-19 disease cases based on laboratory test and phenotypic criteria. The cases had laboratory-confirmed SARS-CoV-2 infection. We uniquely investigated COVID infection genetics in a pediatric population. Our cohort has a large African ancestry component, also unique to our study. We tested for genetic variant association in 498 cases vs. 1,533 controls of African ancestry and 271 cases vs. 855 controls of European ancestry. We acknowledge that the sample size is relatively small, owing to the low prevalence of COVID infection among pediatric individuals. COVID-19 cases averaged 13 years of age. Pediatric genetic studies enhance the ability to detect genetic associations with a limited possible environment impact. Our findings support the notion that some genetic variants, most notably at the SEMA6D, FMN1, ACTN1, PDS5B, NFIA, ADGRL3, MMP27, TENM3, SPRY4, MNS1, and RSU1 loci, play a role in COVID-19 infection susceptibility. The pediatric cohort also shows nominal replication of previously reported adult study results: CCR9, CXCR6, FYCO1, LZTFL1, TDGF1, CCR1, CCR2, CCR3, CCR5, MAPT-AS1, and IFNAR2 gene variants. Reviewing the biological roles of genes implicated here, NFIA looks to be the most interesting as it binds to a palindromic sequence observed in both viral and cellular promoters and in the adenovirus type 2 origin of replication.
Sphingolipid metabolism in T cell responses after allogeneic hematopoietic cell transplantation
Authors: Tian Linlu , Ogretmen Besim , Chung Brian Y. , Yu Xue-Zhong
Published: August 2022

Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective immunotherapy against hematopoietic malignancies. The infused donor lymphocytes attack malignant cells and normal tissues, termed a graft-verse-leukemia (GVL) effect and graft-verse-host (GVH) response or disease (GVHD), respectively. Although engineering techniques toward donor graft selection have made HCT more specific and effective, primary tumor relapse and GVHD are still major concerns post allo-HCT. High-dose systemic steroids remain to be the first line of GVHD treatment, which may lead to steroid-refractory GVHD with a dismal outcome. Therefore, identifying novel therapeutic strategies that prevent GVHD while preserving GVL activity is highly warranted. Sphingolipid metabolism and metabolites play pivotal roles in regulating T-cell homeostasis and biological functions. In this review, we summarized the recent research progress in this evolving field of sphingolipids with a focus on alloreactive T-cell responses in the context of allo-HCT. We discussed how sphingolipid metabolism regulates T-cell mediated GVH and GVL responses in allo-HCT and presented the rationale and means to target sphingolipid metabolism for the control of GVHD and leukemia relapse.
Comparison of EV-free fraction, EVs, and total secretome of amniotic mesenchymal stromal cells for their immunomodulatory potential: a translational perspective
Authors: Papait Andrea , Ragni Enrico , Cargnoni Anna , Vertua Elsa , Romele Pietro , Masserdotti Alice , Perucca Orfei Carlotta , Signoroni Patrizia Bonassi , Magatti Marta , Silini Antonietta R. , De Girolamo Laura , Parolini Ornella
Published: August 2022

Amniotic mesenchymal stromal cells (hAMSCs) have unique immunomodulatory properties demonstrated in vitro and in vivo in various diseases in which the dysregulated immune system plays a major role. The immunomodulatory and pro-regenerative effects of MSCs, among which hAMSCs lie in the bioactive factors they secrete and in their paracrine activity, is well known. The mix of these factors (i.e., secretome) can be either freely secreted or conveyed by extracellular vesicles (EV), thus identifying two components in the cell secretome: EV-free and EV fractions. This study aimed to discern the relative impact of the individual components on the immunomodulatory action of the hAMSC secretome in order to obtain useful information for implementing future therapeutic approaches using immunomodulatory therapies based on the MSC secretome. To this aim, we isolated EVs from the hAMSC secretome (hAMSC-CM) by ultracentrifugation and validated the vesicular product according to the International Society for Extracellular Vesicles (ISEV) criteria. EVs were re-diluted in serum-free medium to maintain the EV concentration initially present in the original CM. We compared the effects of the EV-free and EV fractions with those exerted by hAMSC-CM in toto on the activation and differentiation of immune cell subpopulations belonging to both the innate and adaptive immune systems.

We observed that the EV-free fraction, similar to hAMSC-CM in toto, a) decreases the proliferation of activated peripheral blood mononuclear cells (PBMC), b) reduces the polarization of T cells toward inflammatory Th subsets, and induces the induction of regulatory T cells; c) affects monocyte polarization to antigen-presenting cells fostering the acquisition of anti-inflammatory macrophage (M2) markers; and d) reduces the activation of B lymphocytes and their maturation to plasma cells. We observed instead that all investigated EV fractions, when used in the original concentrations, failed to exert any immunomodulatory effect, even though we show that EVs are internalized by various immune cells within PBMC. These findings suggest that the active component able to induce immune regulation, tested at original concentrations, of the hAMSC secretome resides in factors not conveyed in EVs. However, EVs isolated from hAMSC could exert actions on other cell types, as reported by others.