bluuebunny/crossref_metadata_2025 huggingface dataset:
066. Sleeve Gastrectomy Decrease of TNF-a and Increase TGF-a Gene Expression in the Abdominal Aorta of Rats with Obesity and Diabetes Mellitus
Authors: Saputro Addy , Prasetyo Sigit Adi , Shobirin Muhammad Ali , Rozy Abdul Mughni
Published: November 2024

Background: Sleeve gastrectomy (SG) is one option to significantly reduce body weight while also protecting the cardiovascular system by controlling hyperglycaemia and inflammatory markers. Secretion of tumour necrosis factor (TNF)-? could induce inflammation, meanwhile, the transforming growth factor-? (TGF-?) are anti-inflammatory cytokines, both of which play a role in the process of atherosclerosis. This study aimed to analyse the effect of SG procedure on TNF-? and TGF-? gene expression in the abdominal aorta of obese and DM rats. Method: Fifteen rats were divided into 3 groups: lean-non-DM rats model (C1 group), obese-DM rats model (C2 group), and obese-DM rats model underwent SG (T group). Before and 10 days after the SG procedure, rats’ body weight and fasting blood glucose (FBG) were measured. Ten days after the procedure, TNF-? and TGF-? gene expression were also evaluated by PCR. Results: At the end of the study, mean body weight, FBG levels, and TNF-? gene expression in the C1 group (231.80±4.32 gram; 68.60±2.07 mg/dL; 1.01±0.01 rfu) and T group (232.00±5.33 gram; 114.40±3.20 mg/dL; 1.97±0.57 rfu) were significantly lower than in C2 group (264.60± 3.28 gram; 271.00±6.89 mg/dL; 224.12±47.59 rfu). TGF-? gene expression was found to be considerably higher in T group (25.62 ± 3.03 rfu) compared to C1 group (1.05 ± 0.01 rfu) and C2 group (1.63 ± 0.21 rfu). Conclusion: SG could decrease body weight and FBG, as well as TNF-? gene expression, and increase TGF-? gene expression in the abdominal aorta of rats with obesity and DM.
079. The Diagnostic Duel: Single Immunohistochemistry vs. in Combination with Hematoxylin Eosin in Sentinel Lymph Node Biopsy for Breast Cancer—Insights from a Meta-Analysis
Authors: Anas Muhammad Al , Siregar Kamal Basri
Published: November 2024

Background: The timing of sentinel lymph node biopsy (SLNB) has gained significance with the increased use of neoadjuvant chemotherapy (NAC) in breast cancer. Hematoxylin and eosin (H&E) is the standard histological stain, yet the optimal histopathological protocol for SLNB remains unclear. The role of immunohistochemistry (IHC) in enhancing diagnostic accuracy is still debated. This study evaluates the false-negative rate (FNR) of SLNB in clinically node-negative breast cancer patients after NAC, comparing IHC alone versus IHC combined with H&E staining through a systematic review and meta-analysis. Methods:  We conducted a comprehensive search of PubMed, Embase, and the Cochrane Library from January 2002 to August 2024, focusing on patients undergoing SLNB after NAC followed by axillary lymph node dissection (ALND). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model via Review Manager Software version 5.3. Results: A total of 1,456 patients across 16 studies were analyzed. The FNRs varied from 0% to 33%. The estimated FNR was 1.55 (95% CI: 0.71-3.38) for studies using IHC, while the pooled FNR for H&E alone was 11% (95% CI: 4%-18%) compared to 4% (95% CI: 1%-7%) for H&E with IHC. No significant difference in FNR was observed between the two staining methods (P = 0.28). Conclusion: IHC combined with H&E is technically feasible and offers comparable accuracy for axillary staging in initially clinically node-negative breast cancer patients post-NAC.
082. Ectopic Meningothelial Meningioma of the Soft Palate – A Rare Case Report
Authors: Sepa Krenni , Setiawan I Gede Budhi
Published: November 2024

Background: Ectopic meningiomas are rare neoplasms that occur entirely outside the intracranial and account for only 1–2% of all meningiomas. These tumors have been reported at various sites, however they are predominantly observed in the head and neck region. This study aims to document and analyze a rare case of ectopic meningothelial meningioma of the soft palate. Case: A 52-year-old woman who presented with a complaint of a lump in the roof of her mouth that had appeared five months prior. Examination of the local status through bimanual palpation revealed a mass in the soft palate extending to the oropharynx, displacing both the uvula and the anterior and posterior pillars. On imaging showed a solid, heterogeneous mass with central necrosis located in the right soft palate, extending into the oropharynx. The patient underwent a wide excision, which included ligation of the external carotid artery. Histopathology exams revealed an ectopic meningothelial meningioma. Conclusion: The diagnosis of ectopic meningioma may difficult due the occurrence in uncommon sites. The prognosis for tumours of the palate varies widely, depending on specific factors such as histology, tumor’s grade, margin status, cervical metastasis, and recurrence.
085. Survival Time of Anaplastic Thyroid Cancer with Various of Therapeutic Modalities
Authors: Wibawa I Gede Arya Eka , Adiputra Putu Anda Tusta , Sudarsa I Wayan
Published: November 2024

Background: Anaplastic carcinoma of the thyroid (ATC) is the most aggressive thyroid gland malignancy. Therapies modalities were controversial due to its poor survival prognosis. The survival data after various therapeutic modalities for ATC is still limited. Methods: This study is a retrospective cohort study by taking data from the Cancer Registry in Bali, Denpasar, Indonesia. All patients with anaplastic thyroid cancer who visited Sanglah Hospital in the range 2018 to 2020 were included in this study. Data regarding duration of survival, received treatment modalities, tumor size from radiological data, and laboratories were analyzed with SPSS 25.0. Results: This study included 10 subjects with ATC, mostly male with a mean age of 60.7 years old. The mean survival was 74.8 days with a median survival of 74.5 days. Of the ten patients, 2 patients died without getting any therapy, both surgical and medical therapy. In this study, there was a significant difference in duration of survival between therapeutic modalities. There was no influence of tumor volume factors, gap from initial presentation to therapeutic modality, nodes involved, blood gas analysis at the initial presentation, NLR, PLR, TSH, and FT4 for the survival time of anaplastic thyroid cancer. Conclusion: There is a significant difference in duration of survival between therapeutic modalities for anaplastic ca thyroid. Even so, isthmectomy, tracheostomy, and chemotherapy therapy, only provide an extension of survival time for an average of 40 days.
086. Combination of Mustarde Flap and Paramedian Forehead Flap in Nasal Non-Melanoma Basal Cell Carcinoma: A Case Report
Authors: Pranatalenta Eka , Setiawan I Gede Budhi
Published: November 2024

Background: Basal cell carcinoma (BCC) is a non-melanocytic skin cancer, specifically an epithelial tumor originating from basal cells. The National Comprehensive Cancer Network (NCCN) states that the primary goal of treating BCC is to eliminate the tumor to prevent its locally invasive and damaging characteristics while preserving function and aesthetic appearance as much as possible. This case report details a patient who experienced a defect on the nose due to surgery. Case: A sixty-year-old male patient came to our center with a lump on the right side of his nose, which had developed about 1.5 years prior to his admission. Over the last year, the initially small lump progressively enlarged in both size and depth, becoming ulcerated and necrotic. Clinical examination showed multiple lumps on the right side of the nose with a necrotic edge and ulceration, but without any signs of bleeding. Laboratory tests showed normal results. Conclusion: Facial defects caused by BCC may require various reconstruction approaches depending on the size and location. A combination of skin flap techniques, such as the paramedian forehead flap and Mustardé flap, shows outstanding functional and cosmetic outcomes.
087. Relationship Between Neutrophil-Lymphocyte Ratio and Serum Thyroid Stimulating Hormone Preoperative Thyroidectomy as Predictors of Papillary Thyroid Cancer
Authors: Stevenson William , Lumintang Nico , Tandililing Sherly , Wariki Windy Mariane Virenia
Published: November 2024

Background: Thyroid cancer is the most common endocrine malignancy. The incidence of papillary thyroid cancer has been increasing. Early diagnosis and management are crucial for thyroid cancer. Therefore, the availability of predictive biomarkers for papillary thyroid cancer is important. This study aims to determine whether the preoperative Neutrophil-Lymphocyte Ratio (NLR) and Thyroid Stimulating Hormones (TSH) levels can be used as predictors of papillary thyroid cancer. Methods: Ninety-one patients with thyroid nodules who underwent thyroidectomy surgery at RSUP Prof. DR. R.D. Kandou were retrospectively analyzed. Complete blood count with differential count and serum TSH levels were taken before thyroidectomy. Results: The relationship between TSH levels and papillary thyroid cancer was significant, with a p-value of 0.025, sensitivity of 51.1%, and specificity of 73.9%. The relationship between NLR and papillary thyroid cancer was also significant, with a p-value of <0.001, sensitivity of 68.9%, and specificity of 100%. However, the combination of NLR and TSH did not show a synergistic effect as predictors of papillary thyroid cancer due to several unstudied factors, such as IL-6, IL-37, ROS, NO, and NK cells, which may play a role in the pathogenesis of thyroid cancer.  The limitations of this study include its retrospective cross-sectional design and the lack of further investigation into other factors, such as IL-6, IL-37, ROS, NO, and NK cells, due to limited facilities and time. Conclusion: Both NLR and TSH can be used as predictors of papillary thyroid cancer. NLR is more potent than TSH as a predictor.
088. Transarterial Chemoembolization for Head and Neck Cancer: Case Series
Authors: Sembiring Samuel Pola Karta , Rizki Kiki Akhmad
Published: November 2024

Background: Head and neck cancers represent a diverse group of malignancies arising from the complex anatomy of the oral cavity, pharynx, larynx, nasal cavity, paranasal sinuses, and salivary glands. While traditional treatments like surgery, radiation, and chemotherapy remain mainstays, transarterial chemoembolization (TACE) has emerged as a potential therapeutic option, particularly for advanced or recurrent cases. We present two cases of head and neck cancer that receive TACE. Case: First Case: A 46 years old woman, with big lump on her left cheek. The patient was diagnosed with Basal Cell Adenocarcinoma T3N0M0 at right submandibular region. He has history of Docetaxel and Carboplatin 6 cycles chemotherapy. Second Case: A 51 years old man, complain a lump on his right tongue. The patient was diagnosed with Squamous Cell Carcinoma Well Differentiated at left glossus region. But no history of chemotherapy. Conclusion: Two cases with head and neck cancer in our center has good clinical outcome after receiving chemotherapy through TACE procedure. TACE is offering a targeted approach to deliver chemotherapy and induce tumor necrosis. Although, TACE is commonly used for liver cancer, but it demonstrates promising potential in improving outcomes for head and neck cancer patients in the future.
091. Impact of the Covid-19 Pandemic on Breast Cancer Surgery Care in 8 Institutiona Around Southeast and South Asia
Authors: Priyono Sasongko Hadi , Nurikhwan PW
Published: November 2024

Background: The COVID-19 pandemic brought about unprecedented disruptions to surgical services globally, which could have led to delays in surgical care for breast cancer patients. This study analysed the institutional responses of tertiary hospitals from selected Asian countries to the COVID-19 pandemic. Methods: We identified all patients newly diagnosed with breast cancer from 16 institutions (9 countries: Singapore, Bangladesh, India, Indonesia, Malaysia, Pakistan, Philippines, Sri Lanka and Vietnam) from 11 Mar 2020 to 10 Mar 2021 (“covid”) and compared them to those diagnosed 11 Mar 2019 to 10 Mar 2020 (“precovid”). The following data were collected and retrospectively analysed: number of breast cancer surgeries and timeliness of surgery (days from diagnosis to surgery); type of surgery (breast conserving surgery [BCS], mastectomy without [Ms] and with reconstruction [MRecon]), and clinical stage at diagnosis. Results: 4816 patients (2550 in “precovid” and 2266 in “covid” cohort) were included. Median age at diagnosis was 57 for both cohorts (r, 20-117) (p=0.79). In overall number of cases (n=4877), there is no statistically significant difference between pre- (n=2515, 51.6%) v. covid (n=2362, 48.4%) period (p=0.26). Sequence of treatments was similar in both cohorts (upfront surgery [n=3983 cases, 53.7% v. 46.3%, p=0.08; or surgery after neoadjuvant therapy [n=878 cases, 48.9% v. 51.1%, p=0.79]). Five of 16 institutions experienced a decrease in number of surgeries (p<0.05) during the first year of the pandemic, and across all 3 types of surgery, while 1 institution received more cases (p=0.002). Two other institutions had statistically significant more patients with neoadjuvant therapy (p=0.003 and p<0.001) and 1 of these two showed an increase in BCS (p=0.04) and MRecon (p=0.04) cases during covid compared to the precovid period. Five of 12 institutions had significantly longer waiting time from diagnosis to surgery (p<0.05). Trend analysis per quartile during covid period demonstrated that number of surgeries and timeliness dipped mainly in the first quartile, followed by rapid rebound in surgeries across all institutions in the next 2 quartiles. There was no difference in clinical stage at presentation in the 2 time periods. Conclusion: The COVID-19 pandemic initially impacted the number of breast cancer surgeries performed by institutions in Asia. This was followed by rapid adaptation and restoration of surgical services by institutions.
094. Scrotal Cavernous Hemangioma in A 2 Year Old Child: A Case Report
Authors: Putra Made Jayawisesa Priyambhada , Duarsa Gede Wirya Kusuma
Published: November 2024

Background: Hemangioma is a benign tumor that is commonly found in pediatrics, especially in the early years of life or childhood aged one year and under. Hemangiomas can be found in all areas of the body, including the head and neck, trunk, extremities and genitalia. However, cases of hemangioma in the genital area, especially the scrotum, are very rare. The incidence of hemangiomas is reported to be between 1-3% in neonates and 10-12% in children by the age of 12 months. Generally, hemangiomas are most commonly found in the head and neck region, followed by the trunk and extremities, while hemangiomas in the genital area are rare, occurring in only 2% of cases. The genital areas associated with hemangiomas include the glans, penile shaft, perineum, and may extend to the anterior abdomen and pelvis. Case: A report was made of a two year old boy with complaints of swelling. A two year old boy came in with complaints of swelling in the left scrotum. Examination of the external genitalia area revealed a mass. An MRI of the pelvis with contrast showed a multiloculated septate cystic lesion on the left intrascrotal extratesticular, then excision was performed and samples were taken for histopathological examination. The results of histopathological examination with hematoxylin-eosin staining showed that the tissue section contained proliferation of blood vessels with anastomoses in various shapes and sizes, thin-walled and partially thick and lined with a single layer of endothelial cells without signs of atypia, with an impression consistent with cavernous hemangioma. Conclusion: Scrotal cavernous hemangioma requires special attention and further study, because this case is relatively rare and there is still no definite reference regarding the diagnosis and treatment given.
102. Surgical Treatment of Brachial Artery Aneurysm Associated qith Arteriovenous Shunt for Hemodialysis: Case Report
Authors: Sanjaya Carolus Eko , Sudiasa Ketut
Published: November 2024

Introduction: A brachial artery aneurysm is a rare complication of an arteriovenous fistula (AVF) created for hemodialysis access. This report details the case of a patient with a brachial artery aneurysm associated with an AVF for hemodialysis, who underwent successful surgical treatment.  Case: A 64-year-old female with CKD undergoing regular hemodialysis presented with a painful lump in her right arm one-week AVF installation. Her medical history included a left nephrectomy in 2022, previous failed AV fistula placement, and central dialysis line (CDL) insertion. The patient had a medical history significant for CKD requiring routine HD twice a week. Local examination of the patient's right arm revealed a mobile, painful lump, diagnosed as a brachial artery aneurysm, limiting arm movement. A chest X-ray showed cardiomegaly, thoracic spondylosis, and proper CDL positioning. Laboratory results were normal. The patient underwent surgical repair of the aneurysm and was hospitalized for three days postoperatively. Post-surgery treatment included analgesics, antibiotics, anticoagulation therapy, and outpatient clopidogrel. Conclusions: A brachial artery aneurysm is a rare complication of an AVF, posing risks of peripheral embolism and hand ischemia, and therefore requires surgical correction.
Evaluation of the diversity of the morpho-agronomic characteristics of Corchorus olitorius L. cultivars developed in Saudi Arabia
Authors: ALJuhani Widad S. , ALjohani Ashwaq Yousef
Published: November 2024

Corchorus olitorius is considered a crop with high nutritional value. The C. olitorius crop is cultivated in many regions of Saudi Arabia. There is a lack of research on genetic diversity among these varieties. This work aimed to evaluate the diversity in the morphological characteristics of KSA jute germplasms and compare them to international germplasms. This study included 8 local jute germplasm seeds collected in Saudi Arabia and 16 international jute germplasm seeds from Asia, Africa and the USA. Twenty-one quantitative and qualitative characteristics of the jute samples from the stem, leaves, and fruits were evaluated. These characteristics were evaluated using many reliable statistical methods, such as multivariate analysis and one-way analysis of variance (ANOVA). Morphological traits, especially plant height, days to 50% flowering, leaf blade length, leaf blade width, leaf petiole length, pod pedicel length, pod length, pod width, number of pods per plant and leaf area, significantly differed among the jute samples. This is the first study to compare local jute germplasms in the KSA to international, to provide important information on their morphological diversity. This information can be used in crop improvement and conservation programs.
The Railway as a Cultural Phenomenon and Poetic Text
Authors: Shatin Yu. V.
Published: November 2024

Purpose. The article examines two aspects of the railway: as a cultural phenomenon and as an example of thematic motif in poetic text.

Results. The appearance of the railway was not only an important technical achievement, but also formed a previously unknown cultural code with distinctive features. Firstly, with a paradoxical sense of stability of the path and at the same time, promising disaster in case of deviation, incommensurable rides on horseback. Secondly, with the feeling of simultaneous presence into opposite spaces – at the unchanging point of the carriage and in the constantly changing panorama outside the window. Thirdly, a qualitatively new sense of rhythm, accelerated and hinting as the possibility of change. As a result, a new type of discursive reality arises, leading to an original type of text formation. So, in parallel with the cultural code, another arises – an artistic one, characterized by uniqueness and exclusivity. An example of an artistic code related to the theme of the railway is M. Tsvetaeva’s poem Rails (1923). Based on the tradition of traveling by rail as symbolic movement towards non-existence, Tsvetaeva actualizes the mortal motif in her own way, built on conflict of hard (iron) and soft (canvas), as well as on introducing a musical motif into the text (the linearity of musical lines) along with the original sound recording, creating the effect of a patronymic attraction.

Conclusion. Thus, in the poem Rails we observed the struggle of two models – generative inscribed in the paradigm of culture, and inter-iterative, actively opposing the paradigm and, thanks to syntagma, determining the self-closure of the poetic text.
Russian and Serbian Punctuation of the 21st Century: An Attempt at Comparative Description
Authors: Kim I. E. , Eliseeva M. A.
Published: November 2024

Purpose. The authors conducted a comparative study of the general statistical characteristics of modern Russian and Serbian punctuation practice using the material of Internet texts from the early 20s of the 21st century.

Results. The authors analyzed three important characteristics of punctuation practice: the composition and frequency of punctuation situations, the lexical indicators of syntactic relations used (conjunctions, particles, introductory words, etc.), and the occurrence of punctuation marks. The Russian and Serbian parts of the sample are balanced in terms of the number of uses of punctuation marks and in terms of their focus/lack of focus on compliance with the norm on the Internet platforms provided to the authors of the texts. The comparative study revealed similarities and differences in all analyzed parameters.

Conclusion. It was found that the high degree of similarity of the main indicators caused by the kinship and typological similarity of the languages is combined with obvious differences, including different occurrence of punctuation situations in graphic practice, different composition and different activity of formal indicators of syntactic connection, different density of punctuation marks per punctuation situation. This means that a comparative study of punctuation practice taking into account statistical data allows us to identify the real relationship between the two punctuation systems, rather than the relationship set by normative documents.
Analysis of deepfake crime trends using BIGKinds
Authors:   The Korean Association of Criminal Psychology, Kim Jae Kyeong
Published: November 2024

This study is significant for analyzing criminal trends using deepfake technology based on media reports. A total of 478 articles related to crimes using deepfake technology were extracted from the BIGKinds portal from July 2018 to July 2024. We then analyzed trends over the years using association word analysis. Analysis shows that in 2018-2019, unlike in the early days of AI, deepfake technology usage has increased among the general public. The article also noted that the age range of users has broadened. In particular, he pointed out that deepfake technology is often used for sexual offenses. The year 2020 saw a spike in deepfake crime stories due to COVID-19 and the Nth Room Case incident, with the majority of stories related to illegal pornography distribution and digital sex crimes on Telegram. When looking at recent trends in deepfake crimes from 2021 to 2024, the top stories included the continued rise of digital sex crimes among teens, the increasingly sophisticated ways in which digital sex crimes are being perpetrated, the rise of deepfake sex crimes as a form of entertainment, the escalating impact of deepfake sex crimes, and the use of deepfake technology in voice phishing scams. Based on the results of this analysis, we propose implications for future legal, institutional, and educational aspects of deep fake crimes and limitations of this study.
Classification of Stalking Behavior Within the Coercive Control Dimensions
Authors:   The Korean Association of Criminal Psychology, Jung Hyuna , Jo Eunkyung
Published: November 2024

This study aims to classify perpetrators based on these behaviors, thereby elucidating the theoretical understanding and the relationship between these two concepts. A latent class analysis (LCA) was conducted on 170 stalking cases collected from 18 police agencies nationwide. The analysis identified four distinct perpetrator types: 'Aggressive Control Type,' 'Indirect Threat Type,' 'Exploitative Approacher Type,' and 'Approacher Type.' The findings indicate a potential correlation between the types and levels of coercive control and the patterns of stalking behavior, providing insights into the intersection of stalking and coercive control. Through this, the study facilitates the theoretical advancement of these concepts and provides substantive insights for improving risk assessment and victim protection.
The Impact of Police Contact Experience through the Media on Citizens’ Trust in the Police and Police Effectiveness
Authors:   The Korean Association of Criminal Psychology, Park Ju Ae , Jung Bo Sung
Published: November 2024

This study aimed to examine how media exposure to police encounters influences public trust in the police and perceptions of police effectiveness among 539 residents of Seoul. To achieve this, we categorized different types of media consumption and conducted a latent profile analysis. The key findings are as follows. First, statistical significance was observed across models with two to five latent groups, with the four-profile model emerging as the best fit. Second, when analyzing participants' trust in the police and their perception of police effectiveness by latent profile group, the group with high engagement and a focus on media functionality exhibited the highest levels of trust and perceived effectiveness of the police, followed by the mid-level and low-to-mid-level groups. Conversely, the group with low engagement and a focus on storytelling exhibited the lowest levels of trust and perceived police effectiveness. Third, individuals in the low engagement/storytelling-focused group demonstrated significantly lower trust in the police compared to the low-to-mid-level group, while those in the high engagement/media functionality-focused group showed significantly higher levels of trust. This pattern was consistent with regard to the perception of police effectiveness. The findings of this study suggest that individuals' trust in the police and their assessment of police effectiveness vary depending on the type of media they predominantly consume. This research is significant in understanding how media consumption shapes public trust in law enforcement and its subsequent impact on perceptions of police effectiveness.
THE PATIENT WITH HYDROPERICARDIUM, HYDROTHORAX, ASCITES – THE CLINICAL CHALLANGE FOR INTERNIST
Authors:   Grodno State Medical University, Grodno, Belarus, Surmach K. M. , Demidik S. N. ,   Grodno State Medical University, Grodno, Belarus, Balabanovich T. I. ,   Grodno State Medical University, Grodno, Belarus, Malkin M. R. ,   Grodno State Medical University, Grodno, Belarus, Krauchuk K. A. ,   Grodno clinical hospital №3, Grodno, Belarus, Huts A. N. ,   Grodno clinical hospital №3, Grodno, Belarus, Yaromenka Y. R. ,   Grodno clinical hospital №3, Grodno, Belarus
Published: November 2024

Hypothyroidism is caused by a deficiency of thyroid hormones and presents various clinical manifestations. The possibility of tissue edema should be mentioned in addition to the classic symptoms, such as cold intolerance, fatigue, constipation, bradycardia, depression, drowsiness, hoarseness, weight gain. Tissues edema and the formation of isolated effusions in the cavities (abdominal, pleural and pericardial) are not unusual in hypothyroidism. These manifestations are caused by increased vascular permeability and transudation of fluid and albumin into the interstitial and other spaces (pericardium, pleura), inadequate secretion of antidiuretic hormone, accumulation of hydrophilic glycosaminoglycans in the intercellular spaces of the dermis and various tissues. Multiple effusions in the body cavities and tissue edema are rare to happen simultaneously. The nonspecific nature of these symptoms requires a differential diagnosis, in which hypothyroidism is not always taken into consideration. This situation leads to delay in making a diagnosis and treatment administration, especially in comorbid patients. It is advisable to pay attention to the necessity of thorough analysis of the obtained data and the use of simple differential diagnosis algorithms for the hypothyroidism.
ATRIAL FIBRILLATION: THERAPEUTIC OPPORTUNITIES FOR RESTORING AND MAINTAINING SINUS RHYTHM
Authors:   Grodno State Medical University, Grodno, Belarus, Pyrochkin V. M. , Mironchyk E. V. ,   Grodno State Medical University, Grodno, Belarus, Kalatsei L. V. ,   Grodno State Medical University, Grodno, Belarus, Uskova I. V. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus, Khakalo Zh. K. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus, Mitiagina E. N. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus
Published: November 2024

Patients with atrial fibrillation (AF), especially those with frequent paroxysms, have a high risk of cardiovascular complications. AF is associated with increased mortality, stroke and other thromboembolic events, hospitalizations, heart failure, diminished quality of life, decreased exercise capacity, and left ventricular dysfunction. The article presents the possible ways of restoring and maintaining sinus rhythm in patients with paroxysmal AF.
ФИЗИЧЕСКАЯ РАБОТОСПОСОБНОСТЬ И МАКСИМАЛЬНОЕ ПОТРЕБЛЕНИЕ КИСЛОРОДА У ЮНОШЕЙ, ПОСТУПИВШИХ В ВУЗЫ ИЗ ГОРОДОВ И СЕЛЬСКИХ ПОСЕЛЕНИЙ
Authors: Н.Я. Прокопьев , В.Н. Ананьев , Е.В. Быков , В.В. Зебзеев , В.Б. Рубанович , Е.А. Ветошкина , О.В. Лимаренко , С.В. Романова , О.В. Ананьева , Е.С. Гуртовой
Published: November 2024

В статье представлен анализ уровня физической работоспособности (ФР) по стандартной методике степ теста В.Л. Карпмана у 356 студентов периода юношеского возраста, поступивших в семь профильных ВУЗов России из городов и сельских поселений. Авторами, во-первых, выдвинута гипотеза, что ФР достоверно не зависит от региона проживания, а зависит от профиля получаемого образования. Во-вторых, на ФР юношей и значения МПК влияют ряд совокупных факторов, наиболее существенным из которых является предшествующий поступлению высокий уровень двигательной активности, связанный с регулярными занятиями физкультурой и спортом, как в общеобразовательной школе, так и в ДЮСШ. Показано, что уровень ФР и МПК больше у юношей, обучающихся в специализированных физкультурных вузах.
ВЛИЯНИЕ БАКТЕРИЙ С РАЗНОЙ ФИТОГОРМОНАЛЬНОЙ АКТИВНОСТЬЮ НА РОСТ И ОКСИДАТИВНЫЙ СТРЕСС У РАСТЕНИЙ ПШЕНИЦЫ ПРИ ВЫСОКОЙ ГЕРБИЦИДНОЙ НАГРУЗКЕ
Authors: М.Д. Тимергалин , А.В. Феоктистова , Т.В. Рамеев , А.А. Кенджиева , Д.А. Шарипов , С.Н. Стариков , М.Д. Бакаева , Г.Г. Худайгулов , С.П. Четвериков
Published: November 2024

Показано влияние ризосферных бактерий, продуцирующих и разрушающих различные фитогормоны, на рост растений пшеницы, уровень МДА и содержание хлорофилла в зависимости от гербицидной обработки. Без опрыскивания гербицидом был более эффективен штамм, способный к синтезу ИУК, АБК и деструкции ИУК. Штамм, обладающий способностью к синтезу ИУК, АБК, к деструкции ИУК, АБК и цитокининов, снижал степень окислительного стресса и оказывал ростстимулирующий эффект в условиях сверхнормативной дозы гербицида Чисталан.
ВИДОВЫЕ ОСОБЕННОСТИ ГРИБОВ XYLOTROPHS В НАКОПЛЕНИИ ТЯЖЕЛЫХ МЕТАЛЛОВ
Authors: Г.М. Брыков , В.М. Зубкова , А.В. Гапоненко
Published: November 2024

В статье приводятся данные о размерах накопления тяжелых металлов различными видами кси-лотрофов. Показано, что элементный состав их плодовых тел отличается сильной вариабельностью. Максимальные уровни превышения ПДК обнаружены по кадмию в трутовике плоском, по свинцу и меди - в трутовике дубовом, по цинку - в трутовике окаймленном.
СОДЕРЖАНИЕ НЕКОТОРЫХ ТЯЖЕЛЫХ МЕТАЛЛОВ В ПОЧВАХ ГОРОДА ЯКУТСКА
Authors: Г.Е. Миронова , Л.Д. Олесова , А.А. Григорьева , А.И. Васильева
Published: November 2024

Изучение техногенного загрязнения городских почв, которые являются основой экосистемы, особенно актуально в условиях криолитозоны. В статье приведены данные о содержании тяжелых металлов (свинца, никеля, марганца, кадмия, кобальта, хрома, цинка и меди) в почвах городской и пригородной зон г. Якутска. Концентрацию тяжелых металлов определяли на атомно-абсорбционном спектрометре с электротермической атомизацией модификации МГА-915. Высокие концентрации подвижных форм свинца, цинка и меди обнаружены в почвах с интенсивным движением автотранспорта. При этом уровень свинца, никеля, кобальта, цинка и меди превышал ПДК в 4 точках сбора. Оценка состояния почвенного покрова в пригороде и на территории г. Якутска на основе Zc - комплексного геохимического показателя - показала, что почвы с интенсивным движением автотранспорта относятся к категории умеренно опасного загрязнения.
КОРРЕКЦИЯ ДВИГАТЕЛЬНЫХ НАРУШЕНИЙ У ДЕТЕЙ С ДЕТСКИМ ЦЕРЕБРАЛЬНЫМ ПАРАЛИЧОМ (3 УРОВЕНЬ ПО КЛАССИФИКАЦИИ GMFCS) СРЕДСТВАМИ И МЕТОДАМИ ЛЕЧЕБНОЙ ФИЗИЧЕСКОЙ КУЛЬТУРЫ
Authors: О.Ю. Кичигина , А.С. Лесив
Published: November 2024

В статье рассматривается комплексный подход к физическим упражнениям, направленным на коррекцию основных двигательных нарушений у детей 4-6 лет, с детским церебральным параличом (3 уровень по классификации GMFCS). Все дети были поделены на две сравниваемые группы: экспериментальная и контрольная. Из полученных данных нами выявлено, что показатели уровня развития двигательных способностей экспериментальной группы значительно и достоверно возросли по сравнению с показателями уровня развития двигательных способностей у контрольной группы. Исключением является тест восхождение на 3 ступени» с которым не справились дети ни в одной из групп. Таким образом, констатирующий эксперимент подтвердил данные, полученные в ходе анализа литературных источников. С учетом возрастных особенностей все занятия проходили в игровой форме, что отражено в методике занятий лечебной физической культурой.
ПРЕДПРОЕКТНЫЙ ЛАНДШАФТНО-ЭКОЛОГИЧЕСКИЙ АНАЛИЗ ДЛЯ ОПТИМИЗАЦИИ ГОРОДСКИХ ПРИБРЕЖНЫХ ТЕРРИТОРИЙ (НА ПРИМЕРЕ ВЕРХ-ИСЕТСОГО ПРУДА, Г. ЕКАТЕРИНБУРГ)
Authors: А.А. Саянов , С.В. Борисов , Е.И. Голубева
Published: November 2024

В статье рассматривается современный методический подход к разработке ландшафтно-планировочных решений организации прибрежных речных территории в структуре водно-зеленого городского каркаса. Это важный этап в развитии городской территории и создании доступной и экологически безопасной среды для целей рекреации и охраны природы.
ИССЛЕДОВАНИЕ УСТАНОВКИ ЛАЗЕРНОЙ РЕЗКИ PT-500
Authors: А.В. Шушлебин , С.А. Микаева
Published: November 2024

В статье проведено исследование установки лазерной резки заготовок из листового стекла PT-500. Проведено исследование специальной документации установка лазерной резки заготовок из листового стекла РТ-500 с помощью специальной технологии лазерного управляемого термораскалывания.
مطالب التدريس القائم على المشروعات المدعم بالتقويم الموجه لتعلم طلبة الدراسات العليا بقسم اللغة العربية بجامعة تبوك من وجهة نظر الهيئة التدريسية
Authors: العمراني ليلى فلاح سليم
Published: November 2024

هدفت الدراسة إلى التعرَف على مطالب التدريس القائم على المشروعات المدعم بالتقويم الموجه لتعلم طلاب الدراسات العليا بقسم اللغة العربية من وجهة نظر أعضاء هيئة التدريس بجامعة تبوك. ولتحقيق ذلك استخدمت الباحثة المنهج الوصفي التحليلي، عبر تطبيق استبانة تضمنت (60) فقرة تم توزيعها على عينة قصدية بلغت (41) عضوًا هم جميع أعضاء الهيئة التدريسية في قسم اللغة العربية بجامعة تبوك. وتوصلت النتائج إلى الآتي: حصل عموم الأداة على متوسط حسابي بلغ (4.09 من 5) أي بدرجة موافقة (كبيرة). وحسب المطالب الرئيسة؛ حصلت مطالب تخطيط التدريس القائم على المشروعات، على أعلى متوسط بلغ (4.13)، يليها مطالب تنفيذ التدريس القائم على المشروعات بمتوسط (4.11)، وأخيرًا مطالب تقويم وإدارة نتائج التدريس القائم على المشروعات بمتوسط (4.04)، وجميعها بتقدير موافقة (كبيرة)، كما تبين عدم وجود فروق ذات دلالة إحصائية عند مستوى دلالة 0.05) ≥ α) بين متوسطات درجات تقدير أفراد العينة للمطالب تعزى لمتغيرات: (الجنس، الرتبة العلمية، نوع المؤهل، التدريب)، في حين ظهر فرق دال إحصائيا يعزى لمتغير (سنوات الخبرة) في استجابات أفراد العينة على مطالب تنفيذ التدريس القائم على المشروعات لصالح من يملكون خبرة تدريسية (10 سنوات فأكثر). واستنادا للنتائج قدمت الباحثة جملة من التوصيات والمقترحات لتعزيز مطالب التدريس القائم على المشروعات المدعم بالتقويم الموجه لتعلم طلاب الدراسات العليا بقسم اللغة العربية وعموم الأقسام في جامعات المملكة وعموم الجامعات العربية.
International Roughness Index (IRI) Assessment Based on The Application of ROADBUMP and ROADROID on Sei Duri-Mempawah Road Section
Authors: Januarsih Hafizah , Kadarini S. Nurlaily , Mukti Elsa Tri
Published: November 2024

The research assessed the condition of the Sei Duri-Mempawah road segment using the International Roughness Index (IRI) to determine surface roughness. Two smartphone applications, Roadbump and Roadroid, were evaluated against traditional laser profilometers to measure IRI values. The results indicate that at a speed of 20 km/h, the Roadbump application showed that 26% of the left lane was in good condition, with moderate, slightly damaged, and severely damaged segments accounting for 68%, 4%, and 2%, respectively. For Roadroid at the same speed, the left lane's condition was 76% good, while moderate, slightly damaged, and severely damaged conditions were at 16%, 3%, and 5%. Both applications demonstrated variations in IRI values at higher speeds, with Roadroid generally yielding higher roughness levels than Roadbump. Comparative analysis revealed that Roadbump at 40 km/h provided results closer to the laser profilometer, with up to 78% similarity on the left lane. However, the correlation analysis with BPJN data revealed weak correlations for most cases, except for a stronger relationship (R = 0.5521) between the 40 km/h Roadbump application and the laser profilometer. Thus, Roadbump at 40 km/h is recommended for practical field assessments.
Analysis of Parking Characteristics and Demand in Teratai Traditional Market, Pontianak
Authors: Amanda Sherin , Azwansyah Heri , Kadarini S. Nurlaily
Published: November 2024

The Teratai Traditional Market in Pontianak, Indonesia, faces significant transportation challenges, particularly regarding parking management amid increasing vehicle ownership. The analysis focused on the parking patterns, utilization rates, and efficiency across various zones within the market. The study revealed that Zone A experiences the highest motorcycle activity, especially on weekends, with a utilization rate of 66%. In contrast, car parking in this zone remains limited, with a high turnover but insufficient spaces, resulting in an overcapacity index of 150%. Zones B to E display varied motorcycle and car usage, with motorcycle parking consistently outstripping car usage. The parking area is often inefficient due to irregular vehicle arrangements, lack of surface maintenance, and interference from street vendors, leading to congestion. Improvements include introducing designated markings, restructuring parking angles, and enhancing surface conditions to optimize space and reduce bottlenecks. The analysis recommended expanding motorcycle spaces and better-managing car parking to meet demand. Realignment plans propose 255 motorcycle slots and 12 car spaces, suggesting sufficient motorcycle capacity but a continued shortage of cars. These measures aim to enhance market accessibility, streamline traffic flow, and provide a more efficient parking system for visitors and vendors alike.
Forbidding the Permitted, Permitting the Forbidden-on Drives and Prohibitions in Psychotherapy in The Ultra-Orthodox Religious Community
Authors:   Psychotherapist in Private Practice, Bnei Brak, Israel, Hess Esther
Published: November 2024

The ultra-orthodox (Haredi) Jewish community in Israel adheres to strict observance of religious commandments with regard to separation between the sexes, and demands maximum personal modesty and discretion in all areas related to sexuality. Consequently, many young people find themselves facing a difficult conflict between their natural urges or drives and the restrictions imposed by the religious law (Halacha). In this article, I open a window onto this subject in the hope that the wider therapeutic community will attain a deeper understanding of the suffering and the complex emotional struggles experienced by these young people.
Cliovana: A Pilot Study for Improved Female Sexual Satisfaction
Authors:   Obstetrician-Gynecologist in Fitzroy, Australia, Steinberg Lionel , Ritz Morris ,   Plastic Surgeon in Malvern, Australia
Published: November 2024

Cliovana is a procedure that uses soundwave technology to stimulate the clitoris, with the goal of enhancing sexual pleasure and improving sexual function in women. The treatment is relatively new and has gained attention for its potential to address issues like low libido and difficulty achieving orgasm. Understanding the female orgasm and decreased libido are complex [1]. This essay will explore the background of Cliovana, how it works, its effectiveness, safety, and potential impact on women’s sexual health and well-being.
Relationship between Grandparental Care and Subjective Well-being of the Elderly: Testing the Effect of Inter-generational Care in China
Authors:   Department of Administrative Management, School of Economics & Management, Huzhou University, Huzhou, PR China, Li Hua , Lin Ka ,   College of Public Administration, Zhejiang University, Hangzhou, PR China, Lau Maggie ,   School of Graduate Studies, Lingnan University, Hong Kong, PR China, Hiilamo Heikki ,   Faculty of Social Sciences, University of Helsinki, Finland
Published: November 2024

Objectives: This study explores the association between the four types of grandparenting and the mental health of grandparents in China. Methods: This study analyses the data from the 2018 China Health and Retirement Longitudinal Study (CHARLS) with the application of the General Linear Model. It compares the situation of subjective well-being among the four groups of the Maternal Grandmother (MGMs), the Maternal Grandfathers (MGFs), the paternal grandmothers (PGMs) and the Paternal Grandfathers (PGFs). Results: MGMs’ and the PGMs’ grandparenting behaviour is significantly associated with depression. Nevertheless, this significant feature mainly appears in the families with two parental generations and more than three parental generations but not in the families with only one parental generation. Conclusion: Although grandmothers are more likely to report depression than grandfathers in the cases of grandchild care, grandparenting type is not significantly associated with the feeling of happiness, thus not support the kinship-selection hypothesis.
Sex-Specific Impacts of High-Versus Moderate-Intensity Training on AT1R mRNA Expression and Cardiovascular Stress
Authors:   Department of Physical Education and Sport Sciences, University of Mazandaran, Iran, Pouriamehr Sara , Dabidi Roshan Valiollah ,   Department of Physical Education and Sport Sciences, University of Mazandaran, Iran
Published: November 2024

Objectives: This study aimed to investigate the responses of AT1R mRNA expression, cortisol, and cardiovascular stress to high- versus moderate-intensity training (HIT vs. MIT) among women and men. Methods: 144 participants were allocated to the exercise training groups for both sexes. Right after the HIT and MIT running were performed on a treadmill, AT1R mRNA expression and physiologic stress were measured by real-time PCR and a 12-lead ECG system. Results: Regarding the exercise intensity, although AT1R mRNA expression and O2 pulse values were abruptly higher among men compared to women (p < 0.001), the SpO2 amounts did not change during the recovery period (p > 0.05). Moreover, more time was required for MvO2 to be recovered in men who performed HIT. Conclusion: Despite the fact that various exercise intensities result in temporary physiological stress on the cardiovascular system, especially in men, these challenges are required to improve cardiovascular fitness and it is temporary.
A General Redox-Neutral Platform for Radical Cross-Coupling
Authors: Péter Áron , Sun Jiawei , He Jiayan , Tsien Jet , Zhang Haoxiang , Vokits Benjamin , Peters David , Mandler Michael , Palkowitz Maximilian , Kawamata Yu , Baran Phil
Published: November 2024

Sulfonyl hydrazides are disclosed as versatile radical precursors as exemplified with seven new C–C bond forming, redox neutral cross-couplings with: (1) unsaturated olefins, (2) alkyl halides, (3) redox active esters, (4) aryl halides, (5) alkenyl halides, (6) alkynyl halides, and (7) a trifluoromethylating reagent to forge C(sp3)-C(sp3), C(sp3)-C(sp2), and C(sp3)-C(sp) bonds. Sulfonyl hydrazides are stable and usually crystalline substances that can be accessed in a variety of ways including transiently from hydrazones to achieve a net reductive arylation of carbonyl compounds. Exogenous redox (chemical, photo/electrochemical) additives are not necessary as these functional groups serve the dual role of radical precursor and electron donor. The operational simplicity (homogeneous, water tolerant, dump-and-stir) and practicality of the method are demonstrated as well as applications to streamlining synthesis and mild late-stage functionalization.
Carbon footprint comparison of liquid organic hydrogen carriers cycled thermochemically and electrochemically
Authors: Chilunda Moses D. , Talipov Sarvarjon A. , Biddinger Elizabeth J.
Published: November 2024

Hydrogen (H2) has been proposed as a way to store energy for long durations with minimal carbon footprint. The challenges of using H2 to store energy are that it has very low volumetric density and diffuses rapidly through container walls. Liquid organic hydrogen carriers (LOHCs) have been proposed as a method of storing hydrogen in the molecular backbone of stable organic chemicals, addressing many of the concerns of molecular hydrogen. The majority of LOHC systems proposed have utilized thermochemical cycling for the hydrogenation (to store hydrogen) and dehydrogenation (to release hydrogen). Thermochemical cycling requires heating of the reactors, which results in an increased carbon footprint, and is not easily amenable to dynamic operating with the variable renewable electricity grid. Electrochemical LOHC cycling has been proposed as an alternative to thermochemical cycling because it can pair directly with the variable renewable grid and operate more dynamically. To understand the viability of the thermochemical and electrochemical processes, a comparative carbon footprint analysis is necessary. The analysis showed that the electrochemical LOHC cycling process achieves the lowest carbon footprint when using highly concentrated LOHCs as the feed or when a downstream separation process was not needed. The carbon footprint in electrochemical cycling of diluted LOHC was primarily contributed to by the LOHC distillation separation process. A sensitivity analysis showed the carbon footprint LOHC concentration dependence during the electrochemical cycling process. Moreover, the electrolyte composition significantly affects the carbon footprint during electrochemical LOHC cycling. Decisions regarding use of thermochemical versus electrochemical cycling need to include separation system boundaries, not just the reactors themselves.