bluuebunny/crossref_metadata_2025 huggingface dataset:
National Libyan records on blood cellular elements of the Long-eared hedgehog (Hemiechinus auritus)
Authors: Ibrahim Laila A. , Ilfergane Abdulkarem A. , Tawfeeq Nadhima A.J.
Published: December 2023

This study is an attempt to describe some aspects relating to the blood cells of one of Libya's wildlife animals, the long-eared hedgehog (Hemiechinus auritus). The investigation focused on the morphology of the blood cells in newborn and adult animals that were obtained from the city of Benghazi. Four one-day-old hedgehoglets and 20 adult hedgehogs were utilised to prepare stained blood smears. Structural features of blood cells of both young and adult animals did not show prominent variations from each other. Neutrophils nuclei had a band and multilobulated appearance. The maximal number of nuclear lobes reached seven in the newborn hedgehogs and eight in the adult and the joining threads between the lobes were mostly very obvious. The Barr body could not be observed in neutrophils of the female animals. Non-lobulated nuclei were encountered in the eosinophils of the adult animals,  whereas the nuclear trilobulation could be noticed in the eosinophils of both groups of hedgehogs. Basophils of the newborn hedgehogs showed large irregular nuclei, whereas those of the adults had partially divided indented nuclei. Small, medium and large lymphocytes could be observed in blood films of the newborn and adult animals. However, the majority of the lymphocytes were small in size. Eccentrically located nuclei with kidney-shaped, horseshoe, oval and round appearances were recorded in monocytes of both groups of animals. Platelets of the newborn and adult hedgehogs were non-nucleated and had round to oval shapes. A centrally located dark area surrounded by a less dense area was obvious. The discoid non-nucleated erythrocytes had a biconcave appearance in both groups of hedgehogs.
The Histopathological Characteristics of Gastric Tumor at The National Oncology Center in Benghazi in the Period of 2020-2021
Authors: Elfrgani Lobna Abdalla Omar , Younis Amina B. M. , Murajia Ghazala Alzarouq , Alferjany Muhammed Abdullah , Almograbi Zakia Ibrahim , Yousif Fatma Mohammed , Nori Hanadi Moftah
Published: December 2023

Background: Gastric cancer is considered globally a major health issue. Many studies have shown that adenocarcinomas represent about 90% of all gastric cancers. It is subdivided into two main histological types; intestinal and diffuse. Aim: The aim of this study is to determine the frequency and the histopathological characteristics of gastric adenocarcinoma among patients of the National Cancer Center of Benghazi in the period of 2020-2021. Subjects and methods: A retrospective study of 52 gastric cancer cases from the archive of the National Oncology Center in Benghazi and data was analyzed with SPSS. Results: In the research period between January 2020 to May 2021, the total number of patients with confirmed gastric cancer was 52 cases. The patients' ages were between 29 to 86 and the mean age was 63. Thirty-one (31) cases were male (59.6%) and twenty-one (21) were female (40.4%). Diffuse adenocarcinoma was predominant over the intestinal type (25% and 19.2 % respectively). 48% of the cases were of undetermined type and 3.8% were gastrointestinal stromal tumors. Most of the cases presented at stage IV. Conclusion: The histopathological picture of gastric cancer in our study was similar to a previously published study done in Benghazi with male predominant and diffuse adenocarcinoma as the more common cancer. Some risk factors are attributed such as infection with H pylori, smoking and anemia.
Epäonnistunut sotahistoria
Authors: Jalonen Jussi
Published: December 2023

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Policistinių kiaušidžių sindromo diagnostika ir gydymas: naujos gairės
Authors: Rimkutė Eva , Antanavičiūtė Kamilė , Bumbulienė Žana , Gricius Rimantas , Čeponis Jonas , Žilaitienė Birutė
Published: December 2023

Pirmosios tarptautinės policistinių kiaušidžių sindromo diagnostikos ir gydymo gairės, kurių ruošime dalyvavo 6 pasaulio kontinentų įvairų specialybių eskpertai, apimančios tiek medicininius, tiek gyvensenos, psichologinius, socialinius aspektus, išleistos 2018 metais. 2023 metų rugpjūčio mėnesį buvo publikuotos atnaujintos rekomendacijos. Šių rekomomendacijų svarbiausi aspektai aptariami šioje apžvalgoje. Aprašomi stipresni įrodymai dėl širdies ir kraujagslių ligų, angliavandenių tolerancijos sutrikimo ir 2 tipo cukrinio diabeto, obstrukcinės miego apnėjos ir endometriumo vėžio rizikos šia liga sergančioms pacientėms. Pabrėžiamas būdinumas daugiau dėmesio skirti pacienčių psichologinei sveikatai. Taip pat aptariamas gyvensenos intervencijų būtinumas, medikamentinio gydymo efektyvumo įrodymų lygmuo. Pateikiama informacija apie naujus hirsutizmo gydymo būdus ir stipresnės rekomendacijos dėl nutukimo gydymo medikamentais ir bariatrinės chirurgijos. Aptariami nevaisingumo gydymo, esant policistinių kiaušidžių sindromui, principai. Policistinių kiaušidžių srityje būtini tolesni moksliniai tyrimai, nes daugelio gairėse pateikiamų įrodymų lygmuo yra žemas.
Contra el viejo barbilargo que se cree sabio por esto. Sátira bizantina, en verso, de Teodoro Pródromos (141 H). Texto, traducción y estudio
Authors: Cavallero Pablo
Published: December 2023

Se ofrece una traducción española del texto mencionado, con introducción, anotación y comentario interpretativo, y se destaca que la obra representa el género satura en Bizancio, según una tradición amplia recogida por el 'clasicismo' del s. XII y representada también por Ignorante o el que se dice profesor, La vieja libidinosa y El fanático de Platón, obras con las que ésta tiene puntos de contacto sobre todo en su eje centrado en la oposición ser-parecer.
Von der spätbyzantinischen zur osmanischen topographia sacra in Thrakien: der Derwishkonvent des Qĭzĭl Delü bei Didymoteichon/Dimetoka
Authors: Niehoff-Panagiotidis Johannes
Published: December 2023

In der Fachbibliographie wird der Übergang zwischen der letzten byzantinischen Herrschaft in Nordgriechenland als Bruch beschrieben. Orientalisten beschreiben es als muslimische Eroberung, Byzanzgelehrte als Verlust. Eine gemeinsame Vision beider Positionen ist nicht häufig. Dieses Verfahren vernachlässigt die Tatsache, dass viele Teile Mazedoniens/Thrakiens mehrmals den Besitzer wechselten. Dieser Artikel versucht, osmanische Dokumentation für eine detaillierte Analyse des Territoriums eines der berühmtesten Klöster von Byzanz zu nutzen: dem der Kosmosoteira an der heutigen griechisch-türkischen Grenze in Thrakien (Ferres/Ferecik). Es wurde Mitte des 12. Jahrhunderts von einem berühmten Prinzen der Komneni-Dynastie, Isaac Sebastocrator, dem Sohn von Kaiser Alexius I., gegründet. Im 20. Jahrhundert war es ein Kloster des Bektaschi-Derwisch-Ordens, einer schiitischen Sekte mit Riten, die dem Christentum nahestehen. Was ist in der Zwischenzeit passiert? Wir analysieren die spätbyzantinischen Zeugnisse (Johannes Kantakuzenos) sowie die der Kreuzfahrer im Vergleich zu den ersten osmanischen Dokumenten aus der Region vom Beginn des 15. Jahrhunderts. Das Ergebnis ist überraschend: Das Kloster war bereits in byzantinischer Zeit verlassen und die Sultane übergaben die Gebäude den Sufis des Bektaschi-Ordens. So blieb die mittelalterliche Topographie zumindest teilweise bis weit ins 20. Jahrhundert erhalten.
Teaching speaking in a modern online language environment
Authors: Руденко-Моргун О.И. , Архангельская А.Л. , Макарова Н.С.
Published: December 2023

В статье обсуждается обучение иностранных учащихся говорению с использованием технологии перевернутого класса при смешанном обучении. Описывается внедрение в разработанные авторами обучающие электронные ресурсы инструментов распознавания речи, которые позволяют обучающимся тренировать навыки говорения в формате самостоятельной работы. Доказывается эффективность их применения в рамках технологии перевернутого класса. Проводится анализ и разграничение инструментов распознавания речи по цели их применения: одни могут использоваться только для постановки произношения, другие – для развития навыков разговорной речи. Выдвигается гипотеза об эффективности применения ИИ при обучении иностранцев говорению. Обсуждается вопрос об использовании с этой целью голосовых помощников, в частности «Алисы» от Яндекса. Приводятся виды заданий для развития речи иностранных учащихся при работе с голосовым помощником.

The article discusses teaching speaking to foreign students using flipped classroom technology in the context of blended learning. It describes the introduction of speech recognition tools into the electronic learning resources developed by the authors. Such tools allow students to train speaking skills during independent work with the electronic course. The effectiveness of their application within the flipped classroom technology is proved. The analysis and differentiation of speech recognition tools according to the purpose of their application is carried out: some can be used only for training of pronunciation, while others can help develop conversational skills. A hypothesis about the effectiveness of the use of AI in teaching speaking to foreigners is put forward. The issue of using voice assistants for this purpose, in particular Alice from Yandex, is discussed. The types of tasks for the development of speaking skills when working with a voice assistant are given.
WEB 3 TECHNOLOGIES AND METAVERSES IN THE CONTEXT OF COMPUTER ASSISTED LANGUAGE LEARNING
Authors: Жильцов В.А.
Published: December 2023

Статья посвящена рассмотрению сущности и содержания технологий Web3 и метавселенных в контексте общей компьютерной лингводидактики и обучению РКИ. Данная работа также содержит основные сведения, характеризующие общие тенденции в развитии интернет-технологий в данной парадигме. В статье рассматривается роль виртуального обучения (v-learning) и его основные характеристики применительно к реализации коммуникативного подхода к обучению языку в условиях дистанционного образовательного процесса. Описываются возможности метавселенных для создания виртуальных интерактивных образовательных пространств и языковых сред. Рассмотрены основные особенности метавселенных на примере проекта Spatial, позволяющего создавать интерактивные виртуальные пространства. Тезисы данной статьи иллюстрированы примером демонстрационного проекта виртуального образовательного пространства на платформе Spatial.io.

The article is devoted to consideration of the essence and content of Web3 technologies and metaverses in the context of general computer assisted language learning and teaching Russian as a foreign language. This work also contains basic information characterizing general trends in the development of Internet technologies in Web3 paradigm. The article examines the role of virtual learning (v-learning) and its main characteristics in relation to the implementation of a communicative approach to language learning in the context of the distance educational process. The possibilities of metaverses for creating virtual interactive educational spaces and language environments are described. The main features of metaverses are considered using the example of the Spatial project, which allows you to create interactive virtual spaces. The theses of this article are illustrated by an example of a demonstration project of a virtual educational space on the Spatial.io platform.
THE FACTORS THAT DETERMINE THE EFFECTIVENESS OF TEACHING BILINGUAL CHILDREN RUSSIAN IN EDUCATIONAL CENTERS ABROAD
Authors: Никольская Н.И.
Published: December 2023

В данной статье рассматриваются факторы (назовем их «дополнительные»), которые наряду с основными влияют на успешность обучающихся в центрах русского языка за рубежом. В статье предъявлена анкета, разработанная для статистического описания значимости данных факторов.

In the article it has been hypothesized the existence of factors (we will call them «additional»), which, along with the main ones, have an influence on the success of students in Russian language centers abroad. The article also presented a questionnaire designed for a statistical description of the significance of these factors.
United by history and culture. Russian textbooks for Uzbekistan, Kyrgyzstan and prospects of the Russian language in Armenia
Authors: Шорина Т.А. , Лепеева О.Д. , Штоян Р.Б.
Published: December 2023

В статье представлен обзор УМК по РКИ для Узбекистана, УМК по русскому языку для Кыргызстана, приведены результаты лингвоаудита и анализа учебно-методической базы по русскому языку в Армении. Показаны перспективы русского языка в этих республиках, некоторые методические приемы по созданию мотивационной образовательной среды для изучающих русский язык в общеобразовательных учреждениях. Представлены методики на основе культурологического подхода с акцентом на диалог культур, а также приведены примеры уроков, разработанных с использованием предметно-интегративных технологий согласно уровневым требованиям А2.2.

Russian as a foreign language for Uzbekistan, Russian language for Kyrgyzstan are reviewed in the article, the results of the linguistic audit and analysis of the educational and methodological basis for teaching Russian in Armenia are presented. Russian language prospects in these Republics are shown, as well as some methodological techniques for creating a motivational educational environment for Russian language learners in general education institutions. Methods based on a culturological approach with an emphasis on the dialogue of cultures are presented, as well as examples of lessons developed using subject-integrative technologies according to the A2.2 level requirements.
Identification of Vocational Training Needs of the Youths as a Strategy for Human Capital Development
Authors: Obidile Jacinta Ifeoma , Madu Catherine Omeriyang , Okoli Constance Ifeyinwa
Published: December 2023

The paper identified the vocational training needs of the youths, exploring their demographic possibilities that could influence their choice of vocational training. This becomes important since investment in the youths in terms of empowerment through their preferred vocational training could be an invaluable approach to enhancing the human capital development. The study employed a correlation research design. The participants of the study (N=2,520) were youths drawn from Anambra State using Purposive sampling technique. Data collected were analyzed using mean and standard deviation, bivariate correlation, t-test, chi-square and multiple regression. Findings from the study revealed that vocational training areas in artisan, agriculture, production/service and technical/technology such as; up-cycling and recycling, aquaculture, sales and marketing services, internet and digital services, among others, were identified as vocational training needs of the youths in Anambra State. Findings from multiple regression analysis revealed a significant association between education qualification and production/service training, among others. Based on the findings of the study, it was recommended that the vocational training needs identified by the youths should be revived and made accessible by the government in collaboration with philanthropists and experienced successful entrepreneurs so as to ensure that there is unrestricted access to any preferred vocational training chosen by any youth.
Assessment of implementation of the cybersecurity strategy оf Ukraine taking into account the experience of European and world practices
Authors: GUTSALYUK M.
Published: December 2023

The article analyses the international experience of conducting an assessment of the Cybersecurity Strategy. The emphasis is placed on the need for such an assessment of the Cybersecurity Strategy of Ukraine.
Discussion issues of the place of enforcement proceedings in the system of law of Ukraine
Authors: LYMAR I.
Published: December 2023

The article is devoted to the study of the approaches to determining the legal nature of executive proceedings, its place in the system of law of Ukraine, the analysis of the points of view existing in the scientific literature on executive proceedings as the final stage of the judicial process by conducting a comparative characteristic with other views on the place of executive proceedings in the system of law. In connection with the significant updating of the law in the field of enforcement of decisions, there are many controversial unresolved issues in the theory and practice of applying the law in the enforcement proceedings, since it is impossible to reform the sphere of forced execution without defining the essence and place of enforcement proceedings in the system of law of Ukraine, which stipulates relevance and significance of the research topic. Increasing the effectiveness of the application of new legislation in the area of implementation of decisions is impossible without combining doctrine and practice, which will facilitate the improvement of the procedural mechanism of enforcement of decisions. The determination of sectoral and institutional membership of executive proceedings has a scientific and practical significance, due to the lack of a legal position regarding the clear attachment of the place of enforcement in the system of law of Ukraine. Among other things, the law governing the enforcement of decisions is characterized by heterogeneity of legal norms.
La Deserción Escolar en la Educación Media Superior
Authors: Hernández Osorio José del Carmen
Published: December 2023

La deserción escolar es uno de los problemas por los cuales atraviesan los centros escolares a medida que se avanza en el ciclo escolar, en esta investigación se estudiaron las causas de dicho fenómeno en la educación media superior en un plantel de Santo Domingo Kesté, Champotón, Campeche. Sobre todo, que desde el primer semestre se ve disminuida la asistencia estudiantil, por la tanto, la finalidad es conocer las causas del problema a través de entrevistas realizadas a alumnos, docentes y padres de familia, con respuestas abiertas que permitieron visualizar a profundidad las conductas y circunstancias. que detonan en el abandono académico. Como resultado se encontró, que al ser una comunidad indígena los problemas económicos son la razón principal que deriva a otros, que se van acumulando hasta que el alumno no puede continuar sus estudios y menos si su familia no lo apoya. Como conclusión se halló que tanto docentes como padres de familia, deben entablar comunicación cuando existen problemas económicos y establecer modalidades de evaluación, por otro lado, los directivos deberán buscar apoyos para la población vulnerable en riesgo de abandonar sus estudios.
Estudio de línea base del proyecto Desarrollo de destrezas blandas para el cumplimiento del proyecto de vida en los estudiantes de la Parroquia Sicalpa, Cantón Colta
Authors: Vera Rubio Patricia Elizabeth , Fonseca Morales Ruth Tatiana , Bonilla González Gladys Patricia , Machado Sotomayor Manuel Joaquín , Quishpe Salcán Aida Cecilia , Campos Yedra Hugo Marcelo
Published: December 2023

Estudio de línea base del proyecto Desarrollo de destrezas blandas para el cumplimiento del proyecto de vida en los estudiantes de la Parroquia Sicalpa, Cantón Colta
A Comprehensive Review of Nanocomposite PVDF as a Piezoelectric Material: Evaluating Manufacturing Methods, Energy Efficiency and Performance
Authors: Memarian Farzane , Mohammadi Reza , Akrami Roya , Bodaghi Mahdi , Fotouhi Mohammad
Published: December 2023

Given the escalating concerns surrounding high energy consumption during manufacturing and the environmental impact of piezoelectric materials, the pursuit of sustainable alternatives has emerged as a critical challenge in shaping our technological future. In light of this imperative, this review paper investigates the domain of polymeric piezoelectric materials, with a specific focus on Polyvinylidene fluoride (PVDF) as a promising avenue for sustainable piezoelectric materials with a low-energy production process. The primary objective of this investigation is to conduct a comprehensive assessment of the existing research on the manufacturing processes of polymeric piezoelectric materials to enhance piezoelectric properties while minimizing energy-intensive production techniques. Through rigorous evaluation, the effectiveness of each manufacturing method is scrutinized, enabling the identification of the most energy-efficient approaches. This review paper paves the way for sustainable development and advancement of piezoelectric technologies.
Some terrestrial Parasitengona with new records of the genera Iberochyzeria, Leptus and Charletonia (Trombidiformes: Chyzeriidae, Erythraeidae) from Türkiye
Authors: Kapankaya Alperen , Saboori Alireza , Mayoral Jaime , Cakmak Ibrahim
Published: December 2023

Iberochyzeria fornielesi Mayoral et al., 2018 was reported from larvae collected ectoparasitic on Calliptamus barbarus and Oedipoda caerulescens (Orthoptera: Acrididae) from Spain. In this study, we collected ectoparasitic larvae of I. fornielesi from Calliptamus sp., unidentified Acrididae (Orthoptera) and off host via pitfall traps. This species is reported for the first time in Türkiye and the second time of the genus in the world. The tarsi of I. fornielesi are illustrated and the tarsal setal formula is corrected. Leptus darvishi Saboori et al., 2018 and Charletonia damavandica Karimi Iravanlou et al., 2002 are reported for the first time from Türkiye. Metric and some meristic data of Turkish specimens of I. fornielesi, Leptus rosellae Haitlinger, 1999, L. darvishi, C. damavandica and Neotrombicula vulgaris Schluger, 1955 are presented. An updated key to gagzoi species subgroup of phalangii species group (Leptus) is presented.
Analisis Kejadian Anemia Pada Remaja Putri Usia 12-18 Tahun Di Kelurahan Sambuli Kota Kendari Tahun 2022
Authors: Takin Devi , Zainuddin Asnia , Jafriati Jafriati
Published: December 2023

Kejadian anemia pada remaja menjadi salah satu perhatian pemerintah saat ini terutama remaja putri yang masuk dalam salah satu kelompok rawan menderita anemia. Hal ini dibuktikan dengan tingginya prevalensi anemia pada remaja putri hingga mencapai 53,7% di negara berkembang pada tahun 2019. Anemia dikalangan remaja putri memilki resiko yang besar untuk menderita anemia pada saat kehamilan dan mempunyai resiko tinggi untuk sehingga beresiko menyebabkan kematian ibu. Tidak hanya itu, dampak dari anemia juga beresiko pada sang anak yang dapat menyebabkan calon ibu melahirkan bayi prematur, atau bayi yang lahir dengan berat badan dibawah normal. Penelitian ini dilakukan untuk menganalisis kejadian anemia pada remaja putri khususnya remaja putri usia 12-18 tahun di Kelurahan Sambuli Kecamatan Nambo Kota Kendari yang merupakan salah satu wilayah pesisir di Kota Kendari. Metode penelitian yang digunakan yakni kuantitatif yang bersifat observasional dengan desain penelitian yang dipilih yaitu cross-sectional. Pemilihan sampel dalam penelitian ini dilakukan secara proportionate stratified random sampling sehingga jumlah sampel sebanyak 74 orang usia 12-18 tahun. Analisis yang digunakan yakni analisis bivariat melaui uji Chi-Square menggunakan SPSS versi 25. Penelitian ini memperoleh hasil remaja putri menderita anemia sebanyak 16% dan 58% remaja putri tidak anemia dengan nilai yang diperoleh pengetahuan (p-value = 0,030), pola makan (p-value = 0,000),siklus menstruasi (p-value = 0,000), riwayat penyakit (p-value = 0,202) dan konsumsi tablet tambah darah (p-value = 0,238). Kesimpulan dalam penelitian ini terdapat hubungan pengetahuan, pola makan dan siklus menstruasi dengan kejadian anemia, sedangkan tidak terdapat hubungan antara riwayat penyakit dan konsumsi tablet tambah darah dengan kejadian anemia pada remaja putri.

Kata Kunci: Anemia, Hemoglobin, Remaja Putri 12-18 Usia Tahun
Analisis Faktor Yang Berhubungan Dengan Kejadian Infeksi Saluran Pernapasan Akut (Ispa) Pada Anak Usia 1-5 Tahun Di Wilayah Kerja Puskesmas Wapunto Kabupaten Muna Tahun 2022
Authors: Fadila Sitti , Jafriati Jafriati , Handayani Listy
Published: December 2023

Infeksi Saluran Pernapasan Akut (ISPA) menurut World Health Organization (WHO) merupakan salah satu penyebab kematian tersering pada anak di negara berkembang. Tingginya angka kematian pada anak, selain sering disebabkan karena kondisi kesehatan anak secara kongenital dan faktor lingkungan yang tidak sehat serta kurangnya pengetahuan mengenai ISPA. Kejadian ISPA pada anak di Puskesmas Wapunto menduduki peringkat pertama diantara 10 penyakit yang paling menonjol. Tujuan penelitian ini adalah untuk mengetahui faktor yang berhubungan dengan kejadian ISPA pada anak usia 1-5 tahun di Wilayah Kerja Puskesmas Wapunto Kabupaten Muna Tahun 2022. Jenis penelitian ini adalah analitik observasional dengan pendekatan cross sectional study. Teknik pengambilan sampel dalam penelitian ini accidental sampling dengan besar sampel sebanyak 229 responden dimana responden adalah ibu anak. Hasil dari penelitian ini menunjukkan ada hubungan antara berat badan lahir (p=0,000), ventilasi (p=0,008), paparan asap rokok (p=0,005) dan kepadatan hunian rumah (p=0,009) dengan kejadian ISPA pada anak usia 1-5 tahun sebaliknya tidak ada hubungan status imunisasi (p=0,445) dan status gizi (p=0,445) dengan kejadian ISPA pada anak usia 1-5 tahun. Berdasarkan hasil penelitian ini diharapkan kepada petugas kesehatan Puskesmas Wapunto untuk terus melakukan upaya promosi kesehatan dalam bentuk penyuluhan untuk meningkatkan pengetahuan tentang faktor resiko apa saja yang dapat menyebabkan terjadinya ISPA dan cara pencegahannya.

Kata kunci : ISPA, Anak usia 1-5 tahun, Status Imunisasi, Status Gizi, Lingkungan
Effect of different tea brands on color change of flowable resin composite
Authors: YENİÇERİ ÖZATA Merve , BAKIR Elif Pınar , ÜNAL Samican , POLAT Gamze , AKLEYİN Ebru
Published: December 2023

Aims: This study aimed to evaluate the color change of a low-viscosity fluid resin composite (FRC) aged in 2 different brands of black tea and a Ceylon tea for three different periods (24 hours, 7 days, and 28 days).

Methods: Twenty-eight Filtek Ultimate FRC samples with a diameter of 10 mm and a thickness of 2 mm were prepared and polymerized using polytetrafluoroethylene molds. All samples were numbered and polished, and initial color measurements were made. Samples were divided into three experimental groups and a control group (Distilled water) (n=7). All samples were kept in solutions for 24 hours, 7 days, and 28 days, and at the end of these periods, color measurements were made with a spectrophotometer. Data were recorded according to the CIE Lab system. ΔE was calculated by dividing the sum of squares of the difference of the last and first color measurement values by two. One-way ANOVA and Tukey test were used in the analysis of the data.

Results: The Yellow Label black tea group caused significantly more color change in 24 hours than the Ceylon tea (p
Exploring the impacts of Pycnogenol on pentraxin-3 levels in the heart tissue of rats administered with gentamicin
Authors: ÇAKMAK Tolga
Published: December 2023

Aims: The present study explored if pentraxin-3 (PTX-3) levels, which would be boosted due to cardiac damage by gentamicin, can be regressed thanks to Pycnogenol, which was also previously shown to have desirable impacts on cardiovascular diseases.

Methods: In the study, we recruited 28 8-10-week-old male Sprague-Dawley rats into four groups: control, gentamicin, gentamycin+Pycnogenol, and Pycnogenol. We stained the tissue samples with hematoxylin-eosin and Masson’s trichome dye for histopathological analysis. Then, malondialdehyde (MDA) levels were measured using the spectrophotometric technique. In addition, we measured PTX-3 levels in the heart tissues by an immunohistochemical method.

Results: We discovered the heart tissue samples of the rats in the control and Pycnogenol groups were histologically normal. As well as mononuclear cell increase and degeneration of cardiac muscle cells, we observed mild congestion in the gentamicin group compared to the control group. Despite more significant damage to the heart tissue in the gentamicin+Pycnogenol group compared to the control group, we found that the histopathological damage regressed in this group compared to the gentamicin group. While PTX-3 immunoreactivity was similar between the control and Pycnogenol groups, it was significantly elevated in the gentamicin group compared to the control group (p < 0.001). Moreover, the gentamicin+Pycnogenol group had decreased PTX-3 immunoreactivity than the gentamicin group. While MDA values followed a similar pattern between the control and Pycnogenol groups, these values were found to be significantly increased in the gentamicin group compared to the control group (p < 0.001). These values, however, were decreased in the gentamicin+Pycnogenol group compared to the gentamicin group.

Conclusion: In a nutshell, the present study was able to demonstrate that gentamicin may lead to cardiac damage by boosting PTX-3 levels and that the damage can be regressed thanks to the Pycnogenol treatment.
Turkish children myopia progression in the urban area, a retrospective evaluation
Authors: KAYA Pınar
Published: December 2023

Aims: To investigate myopia trends and progression in urban school-aged myopic children in Turkey.

Methods: This retrospective study included myopic children aged 6-18 years attending the ophthalmology clinic for regular eye and refractive examinations between 2003 and 2021. Myopia progression was calculated as the difference between the baseline and the last visit spherical equivalent refractive (SER) values. Individuals were further categorized to determine the age-specific myopia progression as 6-11, 12-16, and 17-18 age groups based on the school periods of the country. According to the SER values, individuals were classified into mild, moderate, and high myopic groups.

Results: A total of 602 eyes of 301 children (191 female, 110 male) with a mean age of 11.64±2.81 (6-18) years were included in the study. The mean follow-up time of patients was 37.51±19.18 (6-98) months. The baseline mean SER value was -1.5±1.07 D (range: -0.50 and -5.62) and -2.55±1.50 at the final visit. The overall mean myopia progression was -0.35±0.37 D (range: +0.35 D and -3.75 D/year. There were 46 children between 6-11 years, 173 children between 12-16 years, 82 children between 17-18 years, and the annual SER changes were -0.46±0.40 D; -0.37±0.39 D and -0.26±0.29 D in the groups, respectively (p < 0.001). Baseline, final, and annual myopia progression were greater in females. Although there was no statistical significance, myopia progression was faster in moderate myopes (-0.39±0.33 D/a year), followed by mild (-0.35±0.37 D/a year) and high myopes (-0.21±0.20 D/a year) (p=0.37).

Conclusion: The progression of myopia in school-aged Turkish children from the Western Black Sea Region is comparable to the world. Our study revealed the greater myopia progression in the youngest children, moderate myopia group, and females. Myopia prevention recommendations should be carefully advised to the youngest female ones to reduce myopia progression.
Evaluation of distribution and susceptibility of microorganisms isolated from joint fluid cultures: five-year data
Authors: ER Halil , KOCA Özlem , ÖZEN Nevgün Sepin
Published: December 2023

Aims: Septic arthritis is joint inflammation. It is an orthopedic emergency that requires prompt diagnosis and treatment. In this study, it was aimed to examine the distribution and antibiotic resistance profiles of microorganisms isolated from joint fluid samples taken from patients who applied to the orthopedic clinic of our hospital in the last five years.

Methods: In our study, 1162 joint fluid samples were sent to the medical microbiology laboratory of our hospital from the orthopedics and traumatology clinic between January 01, 2018 and December 31, 2022. Joint fluid samples taken from clinically appropriate patients under sterile conditions were incubated in a BacT/Alert 3D (Biomerieux, France) culture device. Bacteria isolated from 164 specimens with growth detected, were identified by matrix-mediated laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) based VITEK MS (Biomerieux, France). Antibiotic susceptibility tests were performed on the VITEK 2 Compact (Biomerieux, France) device.

Results: Staphylococcus aureus (S. aureus) (29.3%) and coagulase negative Staphylococci (CNS) (29.3%) were the most commonly grown microorganisms. Other microorganisms grown were Streptococcus spp. (9.1%), Enterococcus spp. (6.1%), Pseudomonas aeruginosa (P. aeuruginosa) (7.3%), Escherichiae coli (E. coli) (4.3%) and Klebsiella pneumoniae (K. pneumoniae) (4.3%). When antibiotic susceptibility results were evaluated according to EUCAST restricted reporting criteria, linezolid in Gram-positive strains, amikacin in Enterobacterales, colistin and tigecycline in nonfermentative Gram-negative bacteria were found to be the most susceptible antibiotics.

Conclusion: The continuous change in antibiotic susceptibility profiles in joint infections, the long duration of treatment and follow-up, and the increase in polymicrobial infections require regular monitoring of culture and antibiotic susceptibility tests. In our study, the distribution of microorganisms isolated from joint fluid samples of our hospital and the determination of antibiotic resistance profiles will contribute to the clinician in terms of guiding empirical treatment.
The effect of direct-acting antivirals (DAA) on confirmed noninvasive fibrous parameters in chronic hepatitis C patients
Authors: BULUT Dilek , SAYAR Merve Sefa , ACAR Ali
Published: December 2023

Aims: Chronic hepatitis C (CHC) is an important public health problem in terms of the number of people it affects worldwide and the diseases it causes. The high sustained virological response (SVR) rates achieved by the use of direct-acting antiviral (DAA) drugs in the recent period have shown that a new era has begun in this disease. It was aimed to evaluate the effect of DAAs on confirmed noninvasive fibrous parameters together with their effectiveness.

Methods: 75 patients who were started on DAA treatment for CHC were included in the study. In addition, laboratory parameters values at the beginning of the treatment, 12 and 24 weeks after the end of the treatment, hepatitis C virus ribonucleic acid (HCV RNA) results and Aminotransferase-to-Platelet Ratio Index (APRI), Fibrosis-4 (FIB-4) scores were compared.

Results: The most common comorbidity in patients is hypertension (HT), and the most common source of transmission is surgical operations. Genotype 1b was the dominant genotype. The SVR rates of all patients 12 and 24 weeks after the end of treatment were 100%. The APRI and FIB-4 scores of the patients decreased significantly at the 12th and 24th weeks at the end of the treatment compared to the beginning of the treatment.

Conclusion: The confirmed noninvasive fibrous parameters used in the treatment of CHC are useful in evaluating the results of the treatments applied.
Autism spectrum disorder: perspectives from paediatricians
Authors: KUL Müslüm , KARA Mahmut Zabit
Published: December 2023

Aims: Since the first medical contact of children and families is mostly with paediatricians, the knowledge and experience of paediatricians on Autism Spectrum Disorder (ASD) is extremely significant. It was aimed to investigate paediatricians’ general knowledge on ASD, daily practices in the outpatient clinic and ability to recognize warning signs.

Methods: A 40-item questionnaire prepared by the researchers was completed with 116 specialists or subspecialties working in public and private hospitals of two cities in Türkiye.

Results: While 41.7% of paediatricians received rotation training in residency, 32.8 % reported they have enough experience. While 87% considered ASD screening among their duties, only 12.8% stated they have enough time. The number of patients referred for formal assessment of ASD was low. Gender, type of expertise, duration of experience, and sense of competence were not associated with referral frequency. It’s been determined paediatricians have a lack of knowledge about ASD. While not responding to name and difficulty following the instructions were seen as most warning symptoms, other diagnostic criteria and accompanying symptoms were recognized insufficiently.

Conclusions: In addition to increasing the duration and quality of child psychiatry education during residency, regulating the outpatient clinic conditions can overcome an important obstacle in the early diagnosis of ASD.
Evaluation of cardiovascular risk factors, prevalence and determinants of coronary artery disease in renal transplant patients: a single center experience
Authors: CENGİZ ELÇİOĞLU Betül , DEMİRCİ Yasemin , ALTIN Mert Pehlivan , GÜRSOY Erol , AYTEKIN Vedat , AYTEKIN Saide
Published: December 2023

Aims: Cardiovascular disease is the leading cause of morbidity and mortality in renal transplant patients. In our study, we aimed to determine the cardiovascular (CV) risk factors, the prevalence and determinants of coronary artery disease (CAD) in patients who underwent kidney transplantation in our center.

Methods: One hundred sixty nine patients who underwent kidney transplantation in our center were included in the study retrospectively. Demographic and clinical characteristics of the patients, cardiac evaluation findings and further examination results were scanned from the database of our center.

Results: The mean age of the patients was 42.86±12.97 years and 43.19% were female. The most common etiological factors for the development of end-stage renal disease were hypertension (HT) and diabetes mellitus (DM). Ninety seven patients (57.4%) were undergoing dialysis, 4 of whom were on peritoneal dialysis. Renal transplant was performed from a cadaver in two patients and from a living donor in the other patients. CAD was detected in 29 patients (17.15%). The most prevalent CV risk factors were HT and hyperlipidemia (HL). Multivariate logistic regression analysis revealed that age, DM, HL and dialysis history were independent risk factors for the development of CAD. In the postoperative follow-ups, no death or acute coronary syndrome was observed during the hospitalization period.

Conclusion: Prevalence of CV risk factors is high in renal transplant candidates. Our findings support the need for a detailed cardiac evaluation and effective management of CV risk factors in patients preparing for kidney transplantation.
Conditioned media of tonsil derived mesenchymal stem cells shows different rates of cytotoxicity on solid cancer cells
Authors: YÜCE Melek , ALBAYRAK Esra , GÜMÜŞKAPTAN Çağrı
Published: December 2023

Aims: Mesenchymal stem cells (MSCs) are the apple of the eye of cancer studies. It was indicated that the secreted factors, especially released by MSCs, have tumoral or anti-tumoral effects on tumor progression. MSCs obtained from different sources show different anti-tumoral effects, while MSCs originating from the same source also show different tumoral effects in different cancer cells. Here, we investigated the anti-tumor effects of soluble factors secreted from palatine tonsil MSCs (TMSC) as a new source of MSC on human lung carcinoma (A549) and pancreatic cancer (PANC-1) cell lines.

Methods: Conditioned medium (CM) was obtained from TMSCs isolated from palatine tonsil tissue, and the cytotoxic effect of CM on the growth of A549 and PANC-1 in a dose-dependent manner was demonstrated by MTT analysis. In addition, the function of CM treatment on the cell cycle status of cancer cells and the apoptosis process were investigated through cell cycle analysis with propidium iodide (PI) and Annexin-V/PI detection method by flow cytometry analysis, respectively.

Results: We demonstrated that TMSC-CM treatment significantly decreased the viability of A549 and PANC-1 cell lines in a dose-dependent manner post-48 hours. In addition, CM treatment differentially induced the apoptosis on A549 and PANC-1 cells and also, caused G2/M arrest in the cells.

Conclusion: In light of these findings, our study is the first to show that TMSC-CM has an anti-tumoral effect by stimulating apoptosis on A549 and PANC-1 cells. These findings reveal that the usage of CM has a cell-free cellular therapeutic potential.
LA ACCESIBILIDAD COMO UNA NEGACIÓN AL DESARROLLO TURíSTICO SOSTENIBLE EN LA CAMPIí‘A ALTA DE MOCHE
Authors: Sachún Azabache Carlos Martin , Vila Zorogastua Giselo Fortunato , Cervantes Veliz Oscar Fredy
Published: December 2023

El distrito de Moche es considerado como uno de los lugares turí­sticos más importantes del Perú y el sector de la campiña alta de Moche es considerado como el pulmón verde de la metrópoli de Trujillo, territorio que ocupa un importante espacio en el distrito de Moche, donde contiene al monumento arquitectónico como son las huacas del sol y la luna, y que en su entorno paisají­stico es un referente palpable del concepto de desarrollo sustentable; que armoniza con la economí­a, justicia social y la conservación del medio ambiente. Sin embargo, no todo es lo que parece, por lo que intervienen factores como la inequidad de la sostenibilidad, la injusticia ambiental, la influencia del mercado inmobiliario y la inaccesibilidad vehicular y peatonal al lugar. El presente artí­culo cientí­fico plantea la propuesta de un plan de ordenamiento territorial a escala de predios o ramales rurales, que debe ser bajo las estrategias de: integral y sistémico, Participativo, flexible, y carácter prospectivo; esto permitirá que todas las áreas de la campiña alta de Moche se desarrolle uniformemente, permitiendo una accesibilidad vehicular y peatonal para promocionar un turismo vivencial, asegurando un desarrollo sustentable en lo ambiental, social y cultural de la campiña alta de Moche. De tal manera que se conserve la naturalidad del lugar y el visitante lleve una mejor imagen de un desarrollo sostenible. La presencia de una considerable afluencia de turistas ha permitido una accesibilidad reducida para la continuidad de una vida digna. En tal sentido la caracterización y la tendencia a cambios de usos de suelo en la zona de estudio, sostienen la vida económica de la campiña alta de Moche. Por lo tanto la gestión del ordenamiento territorial conjuntamente con la accesibilidad permitirá que el visitante turista colme sus expectativas humanas que ofrece la campiña alta de Moche. Desde el punto de vista metodológico, se recurre a la recopilación, análisis de aquellos instrumentos y organismos más representativos que tienen influencia en el ordenamiento del territorio de la campiña alta de Moche, la bibliografí­a especí­fica, revistas, informes técnicos y sitios web oficiales. Los resultados evidenciaran que aún continúan predominando las concepciones más tradicionales de ordenamiento territorial, manejo y gestión de planificación. Es así­ que este estudio determinará un proyecto de plan de ordenamiento territorial rural, de tal manera permita el desarrollo de un turismo vivencial en todos los sectores de la campiña alta de Moche. Se regulará con un plan básico de instrumentos técnico normativos, con el objetivo de buscar mejorar la calidad de vida de la población, asegurar una accesibilidad para todos, y promover la sustentabilidad ambiental de Moche y la provincia de Trujillo.
PERSPECTIVA DEL VALOR EMPRESARIAL DESDE LAS TEORíAS DEL VALOR OBJETIVO Y SUBJETIVO
Authors: Gutierrez Antonio , Téllez Porcel Hellen Claudia
Published: December 2023

El propósito de este artí­culo radica en abordar la problemática del desafí­o contemporáneo de valorar empresas y marcas, se adentra en el desarrollo histórico del valor económico objetivo y valor económico subjetivo. Su objetivo es proporcionar una comprensión integral que respalde la toma de decisiones estratégicas en un entorno empresarial dinámico. Para ello, se sumerge en la complejidad del valor empresarial y el valor de marca, considerando tanto mediciones financieras objetivas como aspectos intangibles subjetivos. La investigación, de enfoque descriptivo y documental, destaca la necesidad de integrar ambas perspectivas. Se enfoca en revelar la convergencia y divergencia entre el valor objetivo, representado por las métricas financieras tradicionales, y el valor subjetivo, reflejado en elementos intangibles. Este enfoque hí­brido y holí­stico permite una comprensión más completa y profunda del valor empresarial, impulsando decisiones informadas y sólidas en un entorno empresarial altamente competitivo y en constante cambio.
‘Rather a complicated person’: indexing T. E. Lawrence (Lawrence of Arabia)
Authors: Bell Hazel K.
Published: December 2023

Hazel K. Bell recounts the extraordinary difficulties and delays she faced in indexing Jeremy Wilson’s
Authorised biography of T. E. Lawrence
(Lawrence of Arabia) while Wilson was still completing it. She goes on to detail her continuing collaboration with Wilson on the ten volumes he published of Lawrence’s correspondence, all issues of the journal of the T. E. Lawrence Society, and the full text of the 1922 edition of
Seven pillars of wisdom
. In this last index she incorporated terms devised by Lawrence himself as page headings or running titles for the 1926 subscriber edition. Wilson always showed a keen interest in indexing, and planned to upload to the internet a cumulation of all the indexes to his works on Lawrence as a single ‘union index’. It is difficult to establish whether this work was ever completed, or uploaded; little trace remains.
Mondeca for thesaurus, autotagging and ontology management in a public health statistics platform
Authors: Browne Glenda , Moore Helen
Published: December 2023

HealthStats NSW (
www.healthstats.nsw.gov.au
) is a public platform of complex health statistics that displays information on the health of the New South Wales population taken from many data sources. The HealthStats NSW major enhancement project uses Mondeca software to create a thesaurus and ontology which improve search results and are used for automatic webpage creation to assist ‘storytelling’ and navigation. Improving the efficiency of managing content and automating Web content production frees up time and effort of specialised health statisticians and epidemiologists to develop new content and add value to existing content. This paper explores the creation of the thesaurus and its use for autotagging, creation of the ontology component and its use for webpage creation, tweaking of the automated system, and future options for the project.
What’s in an index? The hidden work of book indexing
Authors: Stäheli Urs
Published: December 2023

This paper delves into the cultural and social dimensions of indexes by examining their functionality and production, drawing on discussion of lists as cultural techniques in the literature of the social sciences and cultural studies. A brief overview of the various dimensions of lists emphasises discontinuity – the absence of a narrative or argumentative connection between the items in the list. Lacking a predetermined order, lists have the potential to accommodate different arrangements and comparisons, a concept exemplified by the alphabetical arrangement of an index, which reconfigures a narrative text through its non-narrative structure. This radically different order structure is one of the defining characteristics of an index, providing an opportunity to view the pre-existing text from a new perspective. Acting as a mediator, the largely invisible (and often unappreciated) indexer bridges the gap between the structure of the text and the new order of the developing index, which is the result of a myriad micro-decisions on what to include and exclude. The resultant index not only supplements the existing text but may also challenge the identity of the text itself, a concern that was expressed by early critics of indexes. Examples from literary indexes in the works of Butler, Vonnegut and Perec demonstrate how indexes may deliberately catch the attention of the reader and are far more than functional devices for information retrieval.