bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification and Expression Analysis of the Ethylene Response Factor Gene Family in Tea Plant (Camellia sinensis)
Authors: Zhang Tao , Cai Ju , Wang Sisi , Lv Litang , Yuan Dandan , Zeng Xiaofang , Li Jianrong , Li Yan
Published: July 2023

The ERF gene family is widely present in plants and has crucial regulatory importance in plant seed development, organ morphogenesis, the synthesis of secondary metabolites, and coping with abiotic stresses such as cold and drought. In this study, 90 members of CsERF were screened by bioinformatics tools analysis and named CsERF1–CsERF90. Their molecular characteristics and systematic evolution were studied, and the tissue expression characteristics of CSERF genes and the composition of promoter cis-acting elements were predicted. The results showed that 81 proteins encoded by CsERF genes had conserved motifs 1, 2, and 3, while 64 members possessed other motifs. The theoretical isoelectric point was between 4.49 and 10.24, and 85 members constituted unstable proteins, while the rest were stable proteins. Subcellular localization predicted that 77 members were in the nucleus, 8 were in the chloroplasts, and 5 were in the mitochondria. The promoter sequence of CsERFs was found to include not only cis-acting elements related to hormone regulation, such as gibberellin (41), methyl jasmonate (110), and abscisic acid (185), but also cis-acting elements involved in low-temperature response (56) and light response (22), indicating that CsERFs have a key role in plant growth and abiotic stress. Phylogenetic analysis of tea plant and Arabidopsis thaliana ERF gene families showed that the tea plant ERF gene families could be divided into six groups, with B3 having 29 members at most and B1 having only 3 members at least. The phylogenetic tree constructed using only the CsERF genes is also divided into six groups, with slightly different but minimal differences in members. Of the 90 tea plant ERF members, 85 were located on 15 chromosomes, whereas 5 were not located on chromosomes. The collinearity analysis showed that there were 41 homologous gene pairs among the CsERFs, and these homologous gene pairs may have the same function. According to the expression of CsERFs in cold-stressed tea plant and in different tissues, 90 CsERF genes played their respective roles in different tissues and stages to regulate plant growth, and some of them participated in the process of cold stress tolerance. This study provides a theoretical foundation for the study of tea plant growth and development and low-temperature resistance.
Exogenous Application of Methyl Jasmonate Promotes Yield and Grain Quality of Rice under Terminal Drought Stress
Authors: Meng Yi , Liao Ping , Chen Yuqiong , Weng Wenan , Chen Le , Xu Fangfu , Hu Qun , Xing Zhipeng , Wei Haiyan , Gao Hui , Zhang Hongcheng
Published: July 2023

Exogenous application of methyl jasmonate (MeJA) improves rice drought tolerance, but its effects on rice yield and quality under drought stress during the reproductive phase remain unclear. A pot experiment was conducted to measure rice yield, grain quality, and starch physicochemical properties under three treatments: continuous flooding irrigation throughout the whole growth season (CF), ten days of −40 kPa drought stress at the heading stage (DS), and foliar spraying 100 μmol L−1 MeJA on the first three days of the ten-day −40 kPa heading stage drought stress (DM). An inbred japonica rice variety, Huaidao 5, was the experimental material, and each treatment had 11 replicates for sampling. The results indicated that DS significantly reduced rice yield and quality compared to CF. With increases in superoxide dismutase (+22.2%), peroxidase activities (+10.5%), catalase (+5.0%), and proline content (+5.7%), DM significantly increased 1000-grain weight (+8.6%), filled grain percentage (+3.6%), and yield (+11.1%) compared with DS. Regarding grain quality, DM significantly decreased the chalkiness degree (−12.3%) and protein content (−3.9%) but increased the amylose content (+17.2%) and taste value (+7.3%) relative to DS. In addition, DM improved breakdown viscosity (+17.8%), gelatinization enthalpy (+17.2%), retrogradation enthalpy (+28.0%), 1045/1022 cm−1 ratio (+3.0%), and starch granule morphology compared to DS. In conclusion, exogenous application of 100 μmol L−1 MeJA enhanced the antioxidant capacity of rice leaves, and thus improved starch physicochemical properties to increase grain yield and quality under terminal drought stress.
Population Structure and Genetic Diversity of Rice (Oryza sativa L.) Germplasm from the Democratic Republic of Congo (DRC) Using DArTseq-Derived Single Nucleotide Polymorphism (SNP)
Authors: Kimwemwe Paul Kitenge , Bukomarhe Chance Bahati , Mamati Edward George , Githiri Stephen Mwangi , Civava René Mushizi , Mignouna Jacob , Kimani Wilson , Fofana Mamadou
Published: July 2023

Understanding the genetic diversity and population structure of rice is crucial for breeding programs, conservation efforts, and the development of sustainable agricultural practices. This study aimed to assess the genetic diversity and population structure of 94 rice (Oryza sativa L.) genotypes from the Democratic Republic of Congo using a set of 8389 high-quality DArTseq-based single nucleotide polymorphism (SNP) markers. The average polymorphic information content (PIC) of the markers was 0.25. About 42.4% of the SNPs had a PIC value between 0.25 and 0.5, which were moderately informative. The ADMIXTURE program was used for structure analysis, which revealed five sub-populations (K = 5), with admixtures. In principal component analysis (PCA), the first three principal components accounted for 36.3% of the total variation. Analysis of molecular variance revealed significant variation between sub-populations (36.09%) and within genotypes (34.04%). The low overall number of migrants (Nm = 0.23) and high fixation index (Fst = 0.52) indicated limited gene flow and significant differentiation between the sub-populations. Observed heterozygosity (Ho = 0.08) was lower than expected heterozygosity (He = 0.14) because of the high inbreeding (Fis = 0.52) nature of rice. A high average Euclidean genetic distance (0.87) revealed the existence of genetic diversity among the 94 genotypes. The significant genetic diversity among the evaluated rice genotypes can be further explored to obtain potentially desirable genes for rice improvement.
Synthesis and Antibacterial Activity of Polyalthic Acid Analogs
Authors: Argentin Marcela , Cruz Felipe , Souza Ariana , D’Aurea Elisa , Bastos Jairo , Ambrósio Sérgio , Veneziani Rodrigo , Camargo Ilana , Mizuno Cassia
Published: July 2023

Polyalthic acid (PA) is a diterpene found in copaiba oil. As a continuation of our work with PA, we synthesized PA analogs and investigated their antibacterial effects on preformed biofilms of Staphylococcus epidermidis and determined the minimal inhibitory concentration (MIC) of the best analogs against planktonic bacterial cells. There was no difference in activity between the amides 2a and 2b and their corresponding amines 3a and 3b regarding their ability to eradicate biofilm. PA analogs 2a and 3a were able to significantly eradicate the preformed biofilm of S. epidermidis and were active against all the Gram-positive bacteria tested (Enterococcus faecalis, Enterococcus faecium, S. epidermidis, Staphylococcus aureus), with different MIC depending on the microorganism. Therefore, PA analogs 2a and 3a are of interest for further in vitro and in vivo testing to develop formulations for antibiotic drugs against Gram-positive bacteria.
Spins of Supermassive Black Holes M87* and SgrA* Revealed from the Size of Dark Spots in Event Horizon Telescope Images
Authors: Dokuchaev Vyacheslav Ivanovich
Published: July 2023

We reconstructed dark spots in the images of supermassive black holes SgrA* and M87* provided by the Event Horizon Telescope (EHT) collaboration by using the geometrically thin accretion disk model. In this model, the black hole is highlighted by the hot accretion matter up to the very vicinity of the black hole event horizon. The existence of hot accretion matter in the vicinity of black hole event horizons is predicted by the Blandford–Znajek mechanism, which is confirmed by recent general relativistic MHD simulations in supercomputers. A dark spot in the black hole image in the described model is a gravitationally lensed image of an event horizon globe. The lensed images of event horizons are always projected at the celestial sphere inside the awaited positions of the classical black hole shadows, which are invisible in both cases of M87* and SgrA*. We used the sizes of dark spots in the images of SgrA* and M87* for inferring their spins, 0.65<a<0.9 and a>0.75, accordingly.
Vulnerability Identification and Analysis of Contributors to Desertification in Inner Mongolia
Authors: Chen Yang , Ma Long , Liu Tingxi , Huang Xing , Sun Guohua
Published: July 2023

Desertification vulnerability and contributing factors are of global concern. This study analyzed the spatial and temporal distribution of net primary productivity (NPP), precipitation, and temperature from 1985 to 2015. The rain use efficiency (RUE) of vegetation was selected as an indicator; and desertification vulnerability and contributors were evaluated with the Mann−Kendall test (M−K test) and the Thornthwaite−Memorial model. The results showed that NPP was lower in that years that had lower precipitation and higher temperatures, and vice versa. NPP was spatially consistent with precipitation distribution and roughly opposite to the spatial distribution of the annual change rate of temperature. The desertification vulnerability decreased from west to east, among which both the western sub−region (WSR) and the central sub−region (CSR) had the largest proportion of regions with high desertification vulnerability. On the other hand, the eastern sub−region (ESR) mostly comprises areas with extremely low or low desertification vulnerability. The vulnerability contributors for desertification differed among each sub−region. The desertified regions in WSR and ESR were mainly influenced by human activity (HA), but primarily driven by the combined impact of Precipitation−Temperature (PT) and HA in CSR. The south−east part of the CSR was only affected by HA, whereas the lesser affected regions in the study area were affected by PT and HA simultaneously. The study provides recommendations for the improvement of regional ecological environments to prevent future disasters.
Research Progress of Shear Thickening Electrolyte Based on Liquid–Solid Conversion Mechanism
Authors: Huang Qianqian , Liang Xin , Liu Bing , Deng Huaxia
Published: July 2023

As an essential component of the lithium-ion battery system, electrolyte plays a crucial role in ion transport between the electrodes. In the event of thermal runaway, commercial organic electrolytes are prone to internal disturbances and fires; hence, research on safe electrolytes has gradually become a hot topic during recent years. Shear thickening electrolyte, as a new type of smart electrolyte, can exhibit a liquid state in the absence of external force and rapidly converts to a quasi-solid state once the battery is subjected to drastic impact loading. In this paper, the recent progress of shear thickening electrolytes with liquid–solid switching performance is presented, including its working principles, synthesis and preparation procedure, and battery performance. Additionally, the perspective and challenges for practical application are discussed.
Computational Guided Drug Targets Identification against Extended-Spectrum Beta-Lactamase-Producing Multi-Drug Resistant Uropathogenic Escherichia coli
Authors: Kaur Harpreet , Modgil Vinay , Chaudhary Naveen , Mohan Balvinder , Taneja Neelam
Published: July 2023

Urinary tract infections (UTIs) are one of the most frequent bacterial infections in the world, both in the hospital and community settings. Uropathogenic Escherichia coli (UPEC) are the predominant etiological agents causing UTIs. Extended-spectrum beta-lactamase (ESBL) production is a prominent mechanism of resistance that hinders the antimicrobial treatment of UTIs caused by UPEC and poses a substantial danger to the arsenal of antibiotics now in use. As bacteria have several methods to counteract the effects of antibiotics, identifying new potential drug targets may help in the design of new antimicrobial agents, and in the control of the rising trend of antimicrobial resistance (AMR). The public availability of the entire genome sequences of humans and many disease-causing organisms has accelerated the hunt for viable therapeutic targets. Using a unique, hierarchical, in silico technique using computational tools, we discovered and described potential therapeutic drug targets against the ESBL-producing UPEC strain NA114. Three different sets of proteins (chokepoint, virulence, and resistance genes) were explored in phase 1. In phase 2, proteins shortlisted from phase 1 were analyzed for their essentiality, non-homology to the human genome, and gut flora. In phase 3, the further shortlisted putative drug targets were qualitatively characterized, including their subcellular location, broad-spectrum potential, and druggability evaluations. We found seven distinct targets for the pathogen that showed no similarity to the human proteome. Thus, possibilities for cross-reactivity between a target-specific antibacterial and human proteins were minimized. The subcellular locations of two targets, ECNA114_0085 and ECNA114_1060, were predicted as cytoplasmic and periplasmic, respectively. These proteins play an important role in bacterial peptidoglycan biosynthesis and inositol phosphate metabolism, and can be used in the design of drugs against these bacteria. Inhibition of these proteins will be helpful to combat infections caused by MDR UPEC.
Recent Advancements in Applications of Graphene to Attain Next-Level Solar Cells
Authors: Bagade Sonal Santosh , Patel Shashidhar , Malik M. M. , Patel Piyush K.
Published: July 2023

This paper presents an intensive review covering all the versatile applications of graphene and its derivatives in solar photovoltaic technology. To understand the internal working mechanism for the attainment of highly efficient graphene-based solar cells, graphene’s parameters of control, namely its number of layers and doping concentration are thoroughly discussed. The popular graphene synthesis techniques are studied. A detailed review of various possible applications of utilizing graphene’s attractive properties in solar cell technology is conducted. This paper clearly mentions its applications as an efficient transparent conducting electrode, photoactive layer and Schottky junction formation. The paper also covers advancements in the 10 different types of solar cell technologies caused by the incorporation of graphene and its derivatives in solar cell architecture. Graphene-based solar cells are observed to outperform those solar cells with the same configuration but lacking the presence of graphene in them. Various roles that graphene efficiently performs in the individual type of solar cell technology are also explored. Moreover, bi-layer (and sometimes, tri-layer) graphene is shown to have the potential to fairly uplift the solar cell performance appreciably as well as impart maximum stability to solar cells as compared to multi-layered graphene. The current challenges concerning graphene-based solar cells along with the various strategies adopted to resolve the issues are also mentioned. Hence, graphene and its derivatives are demonstrated to provide a viable path towards light-weight, flexible, cost-friendly, eco-friendly, stable and highly efficient solar cell technology.
Sub-ppm NO2 Detection through Chipless RFID Sensor Functionalized with Reduced SnO2
Authors: Mulloni Viviana , Gaiardo Andrea , Marchi Giada , Valt Matteo , Vanzetti Lia , Donelli Massimo , Lorenzelli Leandro
Published: July 2023

NO2 is an important environmental pollutant and is harmful to human health even at very low concentrations. In this paper, we propose a novel chipless RFID sensor able to work at room temperature and to detect sub-ppm concentration of NO2 in the environment. The sensor is made of a metallic resonator covered with NO2-sensitive tin oxide and works by monitoring both the frequency and the intensity of the output signal. The experimental measurements show a fast response (a few minutes) but a very slow recovery. The sensor could therefore be used for non-continuous threshold monitoring. However, we also demonstrated that the recovery can be strongly accelerated upon exposure to a UV source. This opens the way to the reuse of the sensor, which can be easily regenerated after prolonged exposure and recycled several times.
Integrated Collection of Patient-Reported Outcomes and Experiences in Children with Kidney and Hematological Diseases: A Pilot Study
Authors: Ažukaitis Karolis , Puronaitė Roma , Vaitkevičienė Goda Elizabeta , Trinkūnas Justas , Jankauskienė Augustina , Jankauskienė Danguolė
Published: July 2023

We aimed to explore the feasibility and potential relevance of integrated electronic collection of patient-reported outcome and experience measures (PROM and PREM) in children with special healthcare needs (CSHCN) by using the example of children with kidney and hematological diseases. We performed a cross-sectional, single-center study of children <18 years of age. Children (≥10 years) and their parents received Generic PedsQL Core Scale 4.0 and custom PREM surveys to their email addresses via the REDCap platform, and the results were integrated into the hospital’s electronic health records system. A total of 192 patients (98 with kidney diseases and 94 with hematological diseases) were enrolled. The overall response rate was 51%, and the median time for completion of each proxy questionnaire was approximately three minutes. The lowest PROM scores were observed in the emotional and school functioning dimensions. More favorable experiences in the diagnosis establishment process were associated with higher scores in physical, social, school functioning, and total PROM scores. A better evaluation of the hospital’s environment was associated with higher social functioning, while better information provision correlated with higher physical functioning and total PROM scores. Our data indicates that integrated electronic collection of PROMs and PREMs in the population of CSHCN is feasible, but efforts to increase the response rate are needed. The associations between PROMs and PREMs suggest that future studies exploring targeted interventions at the healthcare service level to improve subjective patient outcomes are needed.
Factors Influencing the Likelihood of Alcohol and Tobacco Use in Adolescent Athletes: Type of Sport, Age, and Action Tendencies in Sport
Authors: Carriedo Alejandro , Cecchini José Antonio , Méndez-Giménez Antonio
Published: July 2023

This article proposes a new approach to understand substance use among adolescent athletes. Thus, this article describes an investigation of the likelihood of alcohol and tobacco use in adolescent athletes considering the type of sport, age, gender, and their action tendencies. A total of 552 athletes with an age range of 12–16 years were engaged in medium–high-contact sports (n = 291) and non-contact sports (n = 261). They completed the Children’s Action Tendency Scale, the Sport Children’s Action Tendency Scale, and the Personal and Social Responsibility Questionnaire. The results showed that 16-year-old athletes were the most likely to drink alcohol and to smoke tobacco (p < 0.001). Likewise, it was found that practicing a medium–high-contact sport was a risk factor for alcohol and tobacco use (p < 0.01). The more aggressive athletes were more likely to have smoked tobacco during the last month (p = 0.019) and also to drink more alcohol that the less aggressive ones (p < 0.001). Finally, the athletes who showed more submissiveness were less likely to have drunk alcohol in the last year and the last month (p < 0.001). These findings show the predictive value of new factors associated with alcohol and tobacco use among adolescent athletes. Preventive measures should be targeted, since a new link between the action tendencies in sport and substance use has been found.
A-DSCNN: Depthwise Separable Convolutional Neural Network Inference Chip Design Using an Approximate Multiplier
Authors: Shang Jin-Jia , Phipps Nicholas , Wey I-Chyn , Teo Tee Hui
Published: July 2023

For Convolutional Neural Networks (CNNs), Depthwise Separable CNN (DSCNN) is the preferred architecture for Application Specific Integrated Circuit (ASIC) implementation on edge devices. It benefits from a multi-mode approximate multiplier proposed in this work. The proposed approximate multiplier uses two 4-bit multiplication operations to implement a 12-bit multiplication operation by reusing the same multiplier array. With this approximate multiplier, sequential multiplication operations are pipelined in a modified DSCNN to fully utilize the Processing Element (PE) array in the convolutional layer. Two versions of Approximate-DSCNN (A-DSCNN) accelerators were implemented on TSMC 40 nm CMOS process with a supply voltage of 0.9 V. At a clock frequency of 200 MHz, the designs achieve 4.78 GOPs/mW and 4.89 GOP/mW power efficiency while occupying 1.16 mm2 and 0.398 mm2 area, respectively.
Investigation of the “Surgical Cuts CO2 Laser Therapy Technique” to Treat Minor Burn Scar Contractures in Children
Authors: Zuccaro Jennifer , Lazzarotto Lisa , Lati Jamil , Kelly Charis , Fish Joel
Published: July 2023

Fractional carbon dioxide (CO2) laser therapy has been shown to improve scar contractures following burns. However, the benefits of using other CO2 laser techniques to treat burn scar contractures are relatively unknown. This pilot study investigated a CO2 laser technique in which a series of perpendicular “surgical cuts” were created along the contracture. The aim of this study was to evaluate the effectiveness of using the “surgical cuts CO2 laser technique” in pediatric patients. This study included 12 participants with minor hand burn scar contractures that received one CO2 laser treatment using the surgical cuts technique. Trained assessors measured contractures pre- and post-laser therapy by assessing range of motion (ROM), digit length, and/or hand-span. All contractures were secondary to contact burns with the mean participant age equal to 5.5 years (SD 3.9). For all participants, at least one of the measured characteristics (ROM, hand-span, and digit length) improved after treatment. This pilot study demonstrated the benefit of using the surgical cuts CO2 laser technique to treat minor burn scar contractures. Future investigations are needed to further evaluate its effectiveness in comparison to the fractional CO2 laser therapy technique.
Spatial Patterns in the Morphological Diversity of Madagascan Frogs
Authors: Escoriza Daniel , Poch Santiago , Boix Dani
Published: July 2023

Madagascar is a biodiversity hotspot, containing a large proportion of endemic species. To make conservation efforts more effective, it is necessary to understand the spatial distribution of this huge biodiversity. In this study, the patterns of morphological variation and diversity in the adult anurans of Madagascar were evaluated and compared across different climatic regions. These patterns were investigated for 370 species (2360 specimens), and the variation in 13 morphological traits obtained from taxonomic databases was assessed. The results revealed differences in body size distribution across climatic regions and that the most morphologically distinctive species occur in humid regions. The analysis also showed that anuran assemblages tend to be more species-rich, more morphologically diverse, and more morphologically clustered in tropical rainforests. These patterns are attributable to regional variations in the amount and seasonality of precipitation. An understanding of the complex patterns of spatial diversity could be useful for regional prioritization in the conservation of Madagascan anurans.
Big Data-Driven Banking Operations: Opportunities, Challenges, and Data Security Perspectives
Authors: Hasan Morshadul , Hoque Ariful , Le Thi
Published: July 2023

At present, with the rise of information technology revolution, such as mobile internet, cloud computing, big data, machine learning, artificial intelligence, and the Internet of Things, the banking industry is ushering in new opportunities and encountering severe challenges. This inspired us to develop the following research concepts to study how data innovation impacts banking. We used qualitative research methods (systematic and bibliometric reviews) to examine research articles obtained from the Web of Science and SCOPUS databases to achieve our research goals. The findings show that data innovation creates opportunities for a well-developed banking supply chain, effective risk management and financial fraud detection, banking customer analytics, and bank decision-making. Also, data-driven banking faces some challenges, such as the availability of more data increasing the complexity of service management and creating fierce competition, the lack of professional data analysts, and data costs. This study also finds that banking security is one of the most important issues; thus, banks need to respond to external and internal cyberattacks and manage vulnerabilities.
A Real-Time Lightweight Detection Algorithm for Deck Crew and the Use of Fishing Nets Based on Improved YOLOv5s Network
Authors: Wang Jiaming , Yin Xiangbo , Li Guodong
Published: July 2023

A real-time monitoring system for the operational status of fishing vessels is an essential element for the modernization of the fishing industry. The operational status of fishing vessels can be identified by using onboard cameras to detect the deck crew and the use of fishing nets. Due to the typically limited processing capacity of shipboard equipment and the significant memory consumption of detection models, general target detection models are unable to perform real-time image detection to identify the operational status of fishing vessels. In this paper, we propose a lightweight real-time deck crew and the use of a fishing net detection method, YOLOv5s-SGC. It is based on the YOLOv5s model, which uses surveillance cameras to obtain video of fishing vessels operating at sea and enhances the dataset. YOLOv5s-SGC replaces the backbone of YOLOv5s with ShuffleNetV2, replaces the feature fusion network with a modified Generalized-FPN, and adds the CBAM attention module in front of the detection head.
Safety Assessment of Herbal Food Supplements: Elemental Profiling and Associated Risk
Authors: Torović Ljilja , Vojvodić Slađana , Lukić Danijela , Srđenović Čonić Branislava , Bijelović Sanja
Published: July 2023

Increased usage of herbal food supplements by both the paediatric and adult populations prompted a health risk assessment study. The elemental profiles of 52 supplements collected in Serbia were obtained using ICP-MS. The calculated contribution to permitted daily exposure was in compliance with the guidelines for elemental impurities: up to 46.8% for Pb (infants), 67.2% for Cu (toddlers), 6.8% for As (preschool children), and 8.0% for Hg (adolescents). Hazard quotients indicated high exposure of toddlers to Cu (100.9%) and Zn (112.7%), although by only one supplement, for which hazard indices ranged from 229 to 105% (aligning from toddlers to adolescents). Based on the margin of exposure, As and Pb were not of safety concern. Conversely, the proportion of supplements exceeding the acceptable level of lifetime cancer risk due to As exposure varied from 41.9% in adolescents to 54.3% in adults. Simultaneous use of multiple supplements over a prolonged period of time could further deepen health concerns.
Effect of Dynamic High-Pressure Microfluidizer on Physicochemical and Microstructural Properties of Whole-Grain Oat Pulp
Authors: Jiang Ping , Kang Ziyue , Zhao Su , Meng Ning , Liu Ming , Tan Bin
Published: July 2023

By avoiding the filtration step and utilizing the whole components of oats, the highest utilization rate of raw materials, improving the nutritional value of products and reducing environmental pollution, can be achieved in the production of whole-grain oat drinks. This study innovatively introduced a dynamic high-pressure microfluidizer (DHPM) into the processing of whole-grain oat pulp, which aimed to achieve the efficient crushing, homogenizing and emulsification of starch, dietary fiber and other substances. Due to DHPM processing, the instability index and slope value were reduced, whereas the β-glucan content, soluble protein content and soluble dietary fiber content were increased. In the samples treated with a pressure of 120 MPa and 150 MPa, 59% and 67% more β-glucan content was released, respectively. The soluble dietary fiber content in the samples treated with a pressure of 120 MPa and 150 MPa was increased by 44.8% and 43.2%, respectively, compared with the sample treated with a pressure of 0 MPa. From the perspective of the relative stability of the sample and nutrient enhancement, the processing pressure of 120 MPa was a good choice. In addition, DHPM processing effectively reduced the average particle size and the relaxation time of the water molecules of whole-grain oat pulp, whereas it increased the apparent viscosity of whole-grain oat pulp; all of the above changes alleviated the gravitational subsidence of particles to a certain extent, and thus the overall stability of the system was improved. Furthermore, CLSM and AFM showed that the samples OM-120 and OM-150 had a more uniform and stable structural system as a whole. This study could provide theoretical guidance for the development of a whole-grain oat drink with improved quality and consistency.
Therapeutic Applications and Effects of Lupinus angustifolius (Blue Lupin) and Its Components: A Systematic Review and Meta-Analysis
Authors: Castillo Rafael Fernández , García Pérez Raquel , González Díaz Ana , Liñán González Antonio
Published: July 2023

Lupinus angustifolius has a unique nutrient profile among legumes and may have beneficial health effects when included in the diet. The aim of this study was to investigate the biological properties of blue lupin (Lupinus angustifolius), its chemical components, and their relevance for monitoring biological and anthropometric health markers, including triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), BMI, weight, and glycemia, compared with control groups with other kinds of diets. PubMed, Web of Science, and Scopus databases, updated to December 2023, were searched. Out of the 194 studies identified, a total of 7 randomized controlled trials (RCTs) comprising 302 participants met the eligibility criteria. The results of our study indicated that the blue lupin diet has a direct relationship with parameters such as blood glucose, weight, and LDL-C but not with TGs or BMI. In conclusion, the research described in this review clearly indicates that L. angustifolius may play an important role in the dietary prevention of hyperlipidemia and hypertension. Therefore, it would be highly advisable to increase its consumption in diets. However, further studies, ideally in humans, are required to truly establish L. angustifolius’s health-promoting properties.
Food and Nutrition Literacy: Exploring the Divide between Research and Practice
Authors: Silva Paula
Published: July 2023

This study addresses the growing recognition of the importance of food and nutrition literacy, while highlighting the limited research in this field, particularly the gap between research and practice. A bibliometric analysis of publications on food and nutrition literacy research from the Scopus database was carried out. Endnote 20, VOSviewer, and Harzing’s Publish or Perish were used to analyze the results. The growth of publications, authorship patterns, collaboration, prolific authors, country contributions, preferred journals, and top-cited articles were the bibliometric indicators used. Subsequently, articles aimed at measuring food or nutrition literacy-implemented programs were analyzed. Existing studies have primarily concentrated on defining and measuring food or nutrition literacy. Although interventions targeting food and nutritional literacy have shown promise in promoting healthy eating, further research is required to identify effective approaches in diverse populations and settings. This study emphasizes the need for additional research to measure intervention program efficacy to enhance the policies and practices in this critical area of public health. These findings underscore the importance of understanding food/nutrition literacy and developing effective interventions to promote healthy eating habits. By bridging the research–practice divide, this study provides valuable insights for policymakers, practitioners, and researchers to address the gaps and improve food/nutrition literacy in various contexts.
Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report
Authors: Vergov Bozhidar , Angelova Andreana , Baldzhieva Alexandra , Kalchev Yordan , Tsochev Georgi , Murdjeva Marianna
Published: July 2023

Improvements in medical care have turned severe diseases into chronic conditions, but often their treatment and the use of medical devices are related to specific complications. Here, we present a clinical case of a long-term dialysis patient who was infected with a rare opportunistic infectious agent—Gordonia sputi. In recent years, the incidence of Gordonia spp. infections in immunocompromised patients with central venous catheters (CVC) has appeared to rise. The isolation and identification of Gordonia spp. are challenging and require modern techniques. In addition, the treatment is usually persistent and often results in CVC extraction, which is associated with further risk and costs for the patient. We also studied the alterations in the immune status of the patient caused by long-term renal replacement therapy and persistent hepatitis C virus infection. Antibiotic therapy and immunostimulation with Inosine pranobex lead to successful eradication of the infection without the need for CVC replacement.
An Evaluation of Continuing Medical Education among Pharmacists in Various Pharmacy Sectors in the Asir Region of Saudi Arabia
Authors: Kandasamy Geetha , Almaghaslah Dalia , Almanasef Mona
Published: July 2023

Background: Continuing medical training is an important component of modern medical practice because it maintains the ability of physicians to provide up-to-date patient care. This study explored pharmacists’ involvement in CME activities and investigated the barriers to undertaking CME activities in Saudi Arabia. It also aimed to highlight the obstacles that prevent pharmacists from participating in CE activities. Methods: This study used a cross-sectional self-administered web-based questionnaire. It was conducted among practising pharmacists in various pharmacy fields in the Asir region of Saudi Arabia. The structured questionnaire consisted of four domains. A convenience sampling strategy was used to select and recruit study participants. The results were described in terms of frequencies and percentages. A Chi-square test was used to assess the differences for categorical data. p value of <0.05 was considered significant. Results and conclusions: A total of 173 pharmacists participated in the study. Attending the conference was the most popular activity (67%), followed by training courses (61.8%) and approved web-based activities (60.1%). Regarding barriers that prevented pharmacists from participating in CME activities, a lack of a scientific database or books was the top-rated barrier that hindered pharmacists from obtaining the required CME hours (79.8%). Another important barrier was the cost of the activities (74.6%). Regarding the area of practice for which pharmacists would be interested in attending CME activities, public health was the favourite (89.6%), followed by personal skills (82.7%). Gathering the required CME hours for re-registration was the main motive for attending CME activities in most of the pharmacy sectors. Policymakers should consider shifting the current CME system to the Continuing Professional Development (CPD) model, which promotes engagement in professional development activities that are relevant to the scope of practice.
Impact of Physical Fitness on Emergency Response: A Case Study of Factors That Influence Individual Responses to Emergencies among University Students
Authors: Bajić Senka , Veljović Dragoljub , Bulajić Borko Đ.
Published: July 2023

(1) Background: The purpose of this study was to ascertain whether there is a direct correlation between the physical fitness of the general population, specifically students, and the response times to fire-emergency-related building evacuations and to identify which physical fitness factors more significantly influenced emergency movement times. (2) Methods: In this quantitative investigation, 21 students (both men and women of the same age) volunteered to participate. We first evaluated their physical fitness; then, we analyzed their reaction times and speed. (3) Results: The results of this study revealed a relationship between emergency response times and evaluations of muscular strength, muscular endurance, muscle power, cardiorespiratory fitness, and body composition. The physically active group demonstrated a stronger initial response (i.e., a shorter time to reach a safe location) to fictitious emergency scenarios. The reduction in the necessary response time did not, however, appear to be related to the degree of flexibility. (4) Conclusions: This study showed how physical fitness might alter initial emergency response times and lessen the effects of a disaster on the general population.
Analysis of the Healthcare System in Romania: A Brief Review
Authors: Petre Ion , Barna Flavia , Gurgus Daniela , Tomescu Laurentiu Cezar , Apostol Adrian , Petre Izabella , Furau Cristian , Năchescu Miruna Lucia , Bordianu Anca
Published: July 2023

This manuscript provides a brief review and analysis of the healthcare system in Romania. This study aims to comprehensively analyse the healthcare system in Romania, evaluating its strengths, weaknesses, and impact on the population’s access to quality healthcare services. Within the framework of the Romanian healthcare system, a multitude of pressing challenges endure. These encompass insufficient funding, shortages of medical personnel, and ineffectiveness in the provisioning of services. These impediments substantially hinder the accessibility of healthcare services, particularly in outlying and pastoral regions, thereby rendering the system susceptible and underserving certain demographics. Our investigation presents three hypotheses. The opening conjecture proposes that inadequate funding has a negative impact on the availability and standard of healthcare facilities in Romania. In addition, another hypothesis assumes that insufficient medical staff plays a considerable role in inequalities in access to and delivery of healthcare. Moreover, the existence of inadequacies in service provision serves as a significant barrier, obstructing the timely and efficient delivery of healthcare to those who need it. Our research encompasses a comprehensive analysis of key aspects of the Romanian healthcare system, ranging from healthcare infrastructure and financing mechanisms to service delivery and healthcare outcomes. Through a blend of qualitative and quantitative data sources, including government reports, academic studies, and statistical data, we have endeavoured to provide an in-depth evaluation. The analysis encompasses various aspects, including healthcare infrastructure, financing mechanisms, service delivery, and healthcare outcomes. Romania has a mixed healthcare system with both public and private providers. The primary level of care is delivered by family doctors, while hospitals and specialised medical centres provide secondary and tertiary care services. This research underlines the criticality of significant alterations being implemented in the healthcare system of Romania to address the issues arising from insufficient funding, a shortage of medical personnel, and shortcomings in service delivery. It is vital to tackle the obstacles presented by insufficient funding, the dearth of healthcare staff, and inadequacies in service delivery to attain impartial and reachable healthcare. By implementing these essential transformations, Romania can pave the way towards a healthcare system that efficaciously caters to the diverse requirements of its populace and guarantees the provision of prompt and superior healthcare services.
High Levels of Anxiety, Depression, Risk of Suicide, and Implications for Treatment in Patients with Lamellar Ichthyosis
Authors: Cortés Hernán , Cariño-Calvo Lizbeth , Reyes-Hernández Octavio D. , Rojas-Márquez Martín , Magaña Jonathan J. , Vizcaino-Dorado Pablo A. , Villegas-Vazquez Edgar Y. , Quintas-Granados Laura Itzel , Jiménez-Islas Elizabeth , Cortés-Mollinedo Valeria A. , Leyva-Gómez Gerardo , González-Del Carmen Manuel
Published: July 2023

Lamellar ichthyosis (LI) is a genodermatosis that injures the structure and function of the skin, affecting the appearance and self-esteem of patients, which may seriously impair their mental health and quality of life. In the present study, we determined anxiety, depression, and suicidal risk levels in patients with LI through the Beck anxiety and depression inventories (BAI and DBI-II, respectively) and the SAD PERSONS scale (SPS). We observed that anxiety, depression, and suicidal ideation were strongly associated with the LI (Cramér’s V = 0.429, 0.594, and 0.462, respectively). Furthermore, patients with LI showed a significant increase in the scores of anxiety, depression, and suicidal risk (p = 0.011, <0.001, and 0.001, respectively) compared to individuals without the disease. Additionally, the suicide risk increased even more in patients who presented comorbidity of anxiety and depression than in patients who presented only anxiety or depression (p = 0.02). Similarly, the increase in the BAI scores correlated with the score observed on the SPS. Our results indicate that patients with LI have higher levels of anxiety and depression compared to individuals without the disease, which could be associated with suicidal risk. Therefore, the collaborative involvement of skin and mental health professionals is necessary to manage patients with LI appropriately. We believe that psychiatric studies and individual evaluations must be performed in LI patients to determine a treatment that, in addition to reducing skin symptoms, focuses on reducing the levels of depression and anxiety and improving the quality of life to reduce the risk of suicide.
Analysis of Vector-Network-Analyzer-Based Power Sensor Calibration Method Application
Authors: Danaci Erkan , Bayrak Yusuf , Cetinkaya Anil , Arslan Murat , Sakarya Handan , Dogan Aliye Kartal , Tunay Gulsun
Published: July 2023

Radio Frequency (RF) power sensor calibration is one of the essential measurements in RF and microwave metrology. For a reliable and accurate power sensor calibration, there are various methods, such as the substitution method, the direct comparison transfer method (DCTM), and the vector network analyzer (VNA)-based calibration method (VBCM). The VBCM is a method that is derived from the DCTM. It is a preferred method since the VNA has a better measurement capability and has fewer connection requirements for measurement devices. In this study, the milestones and potential application errors of the VBCM are given by considering the connection mistakes, measurement faults, calculation errors, and control software coding problems. At the end of the power sensor calibration measurements with the VBCM, the model function components and the uncertainty calculation examples according to the GUM Bayesian method are also presented in this study. In addition, the advantages and disadvantages of the VBCM compared to the former methods are discussed in this study.
Integrated Planning of Feeder Route Selection, Schedule Design, and Fleet Allocation with Multimodal Transport Path Selection Considered
Authors: Guo Liming , Du Jian , Zheng Jianfeng , He Nan
Published: July 2023

In the shipping network optimization, the feeder liner companies not only need to decrease the operation cost by comprehensively optimizing the route, schedule, and fleet but also try to increase the operation income by attracting more shippers, with multimodal transport-path selection considered. Therefore, this paper proposes the integrated planning of feeder route selection, schedule design, and fleet allocation with shippers’ transport-path selection considered. We utilize the nested Logit model to analyze the shipper selection behavior for the multimodal transport path and then formulate a mixed-integer nonlinear programming model of integrated optimization for route, schedule, and fleet. To solve our nonlinear model, we propose a particle swarm optimization (PSO) framework embedded with CPLEX solver by combining the constraint relaxations and the linearization techniques with the heuristic rules. Based on the multimodal transport system in Northern China, computational experiments were conducted to verify the effectiveness of our model and algorithm. The sensitivity analyses of model parameters show that with the increase in ship rent, feeder liner companies should reduce the ship capacity or try to increase the number of port call. With the increase in fuel price, feeder liner companies should reduce the ship speed under the constraints of the arrival-time window and schedule interval. If shippers’ time utility coefficient is high, feeder liner companies should shorten the sailing time of ships by decreasing the number of port calls or shorten the at-port time of ships by increasing the service frequency. If the multimodal transport paths are cost-advantaged or if the waterway transport time has a small impact on multimodal transport time, feeder liner companies should weigh the increase in income and cost when using the measures of time saving. These management insights provide decision support for the operation practice of liner shipping network optimization.
Coastal Environments: Mine Discharges and Infringements on Indigenous Peoples’ Rights
Authors: Kerfoot W. Charles , Swain Gary , Verissimo Luis M. , Johnston Erin , MacLennan Carol A. , Schneider Daniel , Urban Noel R.
Published: July 2023

Over a century ago, copper mills on the Keweenaw Peninsula of Lake Superior sluiced 64 million metric tonnes (MMT) of tailings into coastal waters, creating a metal-rich “halo”. Here we show that relatively small discharges can spread widely in time and space. Mass Mill (2.9 MMT) dumping into Lake Superior also illustrates the complexity of interactions with Indigenous Peoples. A combination of aerial photos, LiDAR, and a microscope technique for distinguishing end-member particles traces the migration of tailings. The clay fraction spread rapidly across Keweenaw Bay and curled into terminal L’Anse Bay, within tribal Reservation boundaries. The coarse stamp sand fraction moved more slowly southward as a beach sand deposit onto Sand Point, a sacred burial ground. Despite the partial recovery of northern beaches and southern sediments, concerns continue about chemical contamination. Mass Mill provides an excellent example of Indigenous Peoples’ territorial and resource issues with mining. A major difficulty with “legacy” discharges is that there are no longer any “responsible parties”. Initially, federal and state officials were fearful that treaty rights might warrant reparations. Recently, multiple agency/state funding programs supported international (IJC) award-winning restoration efforts by tribal members, illustrating how Indigenous Peoples and governments can work together to safeguard treaty rights.