bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of sarcopenia in advanced and metastatic soft tissue sarcoma
Authors: Strassmann Dennis , Hensen Bennet , Grünwald Viktor , Stange Katharina , Eggers Hendrik , Länger Florian , Omar Mohamed , Zardo Patrick , Christiansen Hans , Reuter Christoph W. , Wacker Frank K. , Ganser Arnold , Ivanyi Philipp
Published: July 2021

Introduction

Advanced or metastatic soft tissue sarcoma (a/mSTS) is associated with a dismal prognosis. Patient counseling on treatment aggressiveness is pivotal to avoid over- or undertreatment. Recently, evaluation of body composition markers like the skeletal muscle index (SMI) became focus of interest in a variety of cancers. This study focuses on the prognostic impact of SMI in a/mSTS, retrospectively.

Methods

181 a/mSTS patients were identified, 89 were eligible due to prespecified criteria for SMI assessment. Baseline CT-Scans were analyzed using an institutional software solution. Sarcopenia defining cut-off values for the SMI were established by optimal fitting method. Primary end point was overall survival (OS) and secondary endpoints were progression free survival (PFS), disease control rate (DCR), overall response rate (ORR). Descriptive statistics as well as Kaplan Meier- and Cox regression analyses were administered.

Results

28/89 a/mSTS patients showed sarcopenia. Sarcopenic patients were significantly older, generally tended to receive less multimodal therapies (62 vs. 57 years, P = 0.025; respectively median 2.5 vs. 4, P = 0.132) and showed a significantly lower median OS (4 months [95%CI 1.9–6.0] vs. 16 months [95%CI 8.8–23.2], Log-rank P = 0.002). Sarcopenia was identified as independent prognostic parameter of impaired OS (HR 2.40 [95%-CI 1.4–4.0], P < 0.001). Moreover, DCR of first palliative medical treatment was superior in non-sarcopenic patients (49.2% vs. 25%, P = 0.032).

Conclusion

This study identifies sarcopenia as a prognostic parameter in a/mSTS. Further on, the data suggest that sarcopenia shows a trend of being associated with first line therapy response. SMI is a promising prognostic parameter, which needs further validation.
A note on symmetry breaking in a non linear marketing model
Authors: Caravaggio Andrea , Cerboni Baiardi Lorenzo , Sodini Mauro
Published: July 2021

In this paper, we consider the nonlinear discrete-time dynamic model proposed by Bischi and Baiardi (Chaos Solitons Fractals 79:145-156, 2015a). The model considers players with adaptive adjustment mechanisms towards the best reply and a form of inertia in adopting such mechanism. Moreover, we formulate an extension of the original model, where endogenous market size is considered. Through numerical simulations, we show that multiple attractors may exist in the presence of homogeneous agents and the emergence of non-synchronized trajectories both in the short (on-off intermittency) and long (global riddling) run. Therefore, the article highlights that strategic contexts exist in which the players’ knowledge of the market and the adoption of the best reply do not always allow the use of the representative agent’s rhetoric to describe the dynamics of the model.
On the money creation approach to banking
Authors: Faure Salomon , Gersbach Hans
Published: July 2021

We study today’s two-tier money creation and destruction system: Commercial banks create bank deposits (privately created money) through loans to firms or asset purchases from the private sector. Bank deposits are destroyed when households buy bank equity or when firms repay loans. Central banks create electronic central bank money (publicly created money or reserves) through loans to commercial banks. In a simple general equilibrium setting, we show that symmetric equilibria yield the first-best level of money creation and lending when prices are flexible, regardless of monetary policy and capital regulation. When prices are rigid, we identify the circumstances in which money creation is excessive or breaks down and the ones in which an adequate combination of monetary policy and capital regulation can restore efficiency. Finally, we provide a series of extensions and generalizations of the results.
Osteoprotegerin and RANKL-RANK-OPG-TRAIL signalling axis in heart failure and other cardiovascular diseases
Authors: Dutka Mieczysław , Bobiński Rafał , Wojakowski Wojciech , Francuz Tomasz , Pająk Celina , Zimmer Karolina
Published: July 2021

Osteoprotegerin (OPG) is a glycoprotein involved in the regulation of bone remodelling. OPG regulates osteoclast activity by blocking the interaction between the receptor activator of nuclear factor kappa B (RANK) and its ligand (RANKL). More and more studies confirm the relationship between OPG and cardiovascular diseases. Numerous studies have confirmed that a high plasma concentration of OPG and a low concentration of tumour necrosis factor–related apoptosis inducing ligand (TRAIL) together with a high OPG/TRAIL ratio are predictors of poor prognosis in patients with myocardial infarction. A high plasma OPG concentration and a high ratio of OPG/TRAIL in the acute myocardial infarction are a prognostic indicator of adverse left ventricular remodelling and of the development of heart failure. Ever more data indicates the participation of OPG in the regulation of the function of vascular endothelial cells and the initiation of the atherosclerotic process in the arteries. Additionally, it has been shown that TRAIL has a protective effect on blood vessels and exerts an anti-atherosclerotic effect. The mechanisms of action of both OPG and TRAIL within the cells of the vascular wall are complex and remain largely unclear. However, these mechanisms of action as well as their interaction in the local vascular environment are of great interest to researchers. This article presents the current state of knowledge on the mechanisms of action of OPG and TRAIL in the circulatory system and their role in cardiovascular diseases. Understanding these mechanisms may allow their use as a therapeutic target in cardiovascular diseases in the future.
A First-Principle Study of Monolayer Transition Metal Carbon Trichalcogenides
Authors: Khan Muhammad Yar , Liu Yan , Wang Tao , Long Hu , Chen Miaogen , Gao Dawei
Published: July 2021

Monolayer MnCX3 metal–carbon trichalcogenides have been investigated by using the first-principle calculations. The compounds show half-metallic ferromagnetic characters. Our results reveal that their electronic and magnetic properties can be altered by applying uniaxial or biaxial strain. By tuning the strength of the external strain, the electronic bandgap and magnetic ordering of the compounds change and result in a phase transition from the half-metallic to the semiconducting phase. Furthermore, the vibrational and thermodynamic stability of the two-dimensional structure has been verified by calculating the phonon dispersion and molecular dynamics. Our study paves guidance for the potential applications of these two mono-layers in the future for spintronics and straintronics devices.
The effect of polyhedral oligomeric silsesquioxanes (POSSs) incorporation in ethylene-propylene-diene-terpolymer (EPDM): a thermal study
Authors: Blanco Ignazio , Zaharescu Traian
Published: July 2021

A series of ethylene-propylene-diene-terpolymer (EPDM)/polyhedral oligomeric silsesquioxane (POSS) composites at different percentage of POSS were prepared and subjected to γ-irradiation. Both irradiated and non-irradiated EPDM and composites were investigated by the means of thermal analysis to verify if the presence of POSS molecules is able to reduce the oxidation level of free radicals generated during the degradation and to evaluate the effects of the irradiation. EPDM composites at 1, 3 and 5 mass% of POSS were thus degraded in a thermogravimetric (TG) balance in dynamic heating conditions (25–700 °C), in both inert and oxidative atmosphere by flowing nitrogen and air respectively. Thermal characterization was then completed by carrying out Differential Scanning Calorimetry (DSC) analysis from sub-ambient to better highlight the melting of the polymer and polymer composites occurring just above the room temperature. FTIR spectroscopy was also performed for the prepared samples to check the presence of the molecular filler in the composites and for the TG’s residue at 700 °C, in order to evaluate its nature. DSC and TGA parameters were detected and discussed to have information about the effect of the degradation’s environment, the effect of irradiation on polymer stabilization and the effect of POSS content in the polymer matrix.
Comparison of human blood serum DSC profiles in aqueous and PBS buffer solutions
Authors: Michnik Anna , Kiełboń Agnieszka , Duch Klaudia , Sadowska-Krępa Ewa , Pokora Ilona
Published: July 2021

The results of studies of physiological fluids by differential scanning calorimetry (DSC) for the purpose of diagnosis and monitoring of diseases are promising. Before the DSC method is accepted in medical diagnostics, it is worth experimenting with various environmental conditions at the research stage. Among other things, it is important to choose an appropriate solvent to dilute the tested biological fluids. In this work, human blood sera DSC profiles in aqueous and PBS (phosphate-buffered saline) solutions have been compared. Visibility of haptoglobin in the DSC profile of human blood serum is much better in water solution. In addition, contributions from albumin and haptoglobin are well separated in contrast to the PBS serum solutions. The peak or shoulder at about 83 °C which represents contributions from the CH3 domain of immunoglobulin IgG1 and/or transferrin is more clearly visible in PBS solution. The results show that the type of solvent is essential when interpreting the serum DSC profile.
Correction to: Visible lattice points along curves
Authors: Liu Kui , Meng Xianchang
Published: July 2021

The article “Visible lattice points along curves”, written by Kui Liu and Xianchang Meng, was originally published electronically on the publisher’s internet portal on 27 July 2020 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 9 July 2021 to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0.
Analysis of profibrogenic microRNAs (miRNAs) expression in urine and serum of chronic kidney disease (CKD) stage 1–4 patients and their relationship with proteinuria and kidney function
Authors: Donderski Rafał , Szczepanek Joanna , Naruszewicz Natalia , Naruszewicz Renata , Tretyn Andrzej , Skoczylas-Makowska Natalia , Tyloch Janusz , Odrowąż-Sypniewska Grażyna , Manitius Jacek
Published: July 2021

Purpose

Besides conventional kidney diseases diagnostics, micro RNAs (miRNAs) assessment in urine and serum is considered to be a promising non-invasive method of diagnostics of renal parenchymal diseases and valuable therapeutic target also. The purpose of the study was to investigate the role of several miRNAs as a markers of kidney damage.

Methods

Assessment of 45 chronic kidney disease (CKD) patients stage 1–4 and 17 healthy control. Sample of urine and blood was taken from each participant for molecular analysis using Real Time PCR method to identify such micro-RNAs as: hsa-miR-155-5p, hsa-miR-214-3p, hsa-miR-200a-5p, hsa-miR-29a-5p, hsa-miR-21-5p, hsa-miR-93-5p, and hsa-miR-196a-5p. Basic biochemical test was done. Analysis was performed in CKD patients group and subgroup with chronic glomerulonephritis (CGN) confirmed by kidney biopsy. Moreover, analysis was performed in subgroup with different estimated glomerular filtration rate (eGFR) (according to CKD–EPI equation: eGFR < 60 ml/min, eGFR > 60 ml/min) and different daily protein excretion (DPE): (DPE < 3.5 g; DPE > 3.5 g).

Results

Increased relative expression of hsa-miR-29-5p, hsa-miR-21-5p, and hsa-miR-196a-5p and decreased expression of hsa-miR-155-5p, hsa-miR-214-5p, hsa-miR-200a-5p, and hsa-miR-93-5p was demonstrated in urine of analyzed CKD patients. In subpopulation of chronic glomerulonephritis (CGN) patients, there was higher level of expression in urine of hsa-miR-155-5p, hsa-miR 214-3p, hsa-miR-93-5p, and hsa-miR-196a-5p in CGN with DPE < 3.5 g. CGN patients with eGFR < 60 ml/min showed higher expression level of miRNAs such as hsa-miR-214-3p, hsa-miR-29-5p, hsa-miR-93-5p, and hsa-miR-196-5p in urine. There was increase in hsa-miR 155-5p, hsa-miR-214-3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR-21-5p, and hsa-miR-93-5p expression. Increased level of expression of hsa-miR-155-5p; hsa-miR-214-3p, hsa-miR-200a-5p, and hsa-miR-29-5p was found in CGN patients with eGFR > 60 ml/min.

Conclusion

Increased relative expression of profibrogenic miRNAs in urine or serum of CKD patients with eGFR > 60 ml/min and DPE < 3.5 g may indicate higher degree of fibrosis at early CKD stages.
Lord–Wingersky Algorithm Version 2.5 with Applications
Authors: Huang Sijia , Cai Li
Published: July 2021

Item response theory scoring based on summed scores is employed frequently in the practice of educational and psychological measurement. Lord and Wingersky (Appl Psychol Meas 8(4):453–461, 1984) proposed a recursive algorithm to compute the summed score likelihood. Cai (Psychometrika 80(2):535–559, 2015) extended the original Lord–Wingersky algorithm to the case of two-tier multidimensional item factor models and called it Lord–Wingersky algorithm Version 2.0. The 2.0 algorithm utilizes dimension reduction to efficiently compute summed score likelihoods associated with the general dimensions in the model. The output of the algorithm is useful for various purposes, for example, scoring, scale alignment, and model fit checking. In the research reported here, a further extension to the Lord–Wingersky algorithm 2.0 is proposed. The new algorithm, which we call Lord–Wingersky algorithm Version 2.5, yields the summed score likelihoods for all latent variables in the model conditional on observed score combinations. The proposed algorithm is illustrated with empirical data for three potential application areas: (a) describing achievement growth using score combinations across adjacent grades, (b) identification of noteworthy subscores for reporting, and (c) detection of aberrant responses.
EU-28’s progress toward the 2020 renewable energy share: a club convergence analysis
Authors: Presno María José , Landajo Manuel
Published: July 2021

This paper assesses the convergence of the EU-28 countries toward their common goal of 20% in the renewable energy share indicator by year 2020. The potential presence of clubs of convergence toward different steady-state equilibria is also analyzed from both the standpoints of global convergence to the 20% goal and specific convergence to the various targets assigned to Member States. Two clubs of convergence are detected in the former case, each corresponding to different renewable energy source targets. A probit model is also fitted with the aim of better understanding the determinants of club membership, which seemingly include real GDP per capita, expenditure on environmental protection, energy dependence, and nuclear capacity, with all of them having statistically significant effects. Finally, convergence is also analyzed separately for the transport, heating and cooling, and electricity sectors.
Freshwater alga Raphidocelis subcapitata undergoes metabolomic changes in response to electrostatic adhesion by micrometer-sized nylon 6 particles
Authors: Mizukami-Murata Satomi , Suzuki Yuji , Sakurai Kensuke , Yamashita Hiromasa
Published: July 2021

Nylon powders are a type of microplastic (MP) used in personal care products such as cosmetics and sunscreens. To determine the effects of nylon polymers on freshwater microalgae, we investigated the effects of two types of micrometer-sized nylon polymers, i.e., powdered nylon 6 (Ny6-P) and nylon 12 (Ny12), and four other micrometer-sized MPs, i.e., low-density polyethylene, polyethylene terephthalate, polystyrene, and ultra-high-molecular-weight polyethylene, on the microalga Raphidocelis subcapitata. The results showed that Ny6-P inhibited R. subcapitata growth more than the other MPs; R. subcapitata growth was inhibited by 54.2% with 6.25 mg/L Ny6-P compared with the control. Ny6-P in the culture media adhered to R. subcapitata cells electrostatically, which may have disrupted growth and photosynthetic activity. Metabolomic analysis revealed that many metabolites related to the amino acid catabolic pathway and γ-glutamyl cycle were induced, which might trigger responses to avoid starvation and oxidative stress. Our study provides important information on the effects of Ny6-P on algae in freshwater environments.
Confronting repressive ideologies with critical pedagogy in science classrooms
Authors: Lodge Wilton
Published: July 2021

The focus of this response to Arthur Galamba and Brian Matthews’s ‘Science education against the rise of fascist and authoritarian movements: towards the development of a Pedagogy for Democracy’ is to underpin a critical pedagogy that can be used as a counterbalancing force against repressive ideologies within science classrooms. Locating science education within the traditions of critical pedagogy allows us to interrogate some of the historical, theoretical, and practical contradictions that have challenged the field, and to consider science learning as part of a wider struggle for social justice in education. My analysis draws specifically on the intellectual ideas of Paulo Freire, whose work continues to influence issues of theoretical, political, and pedagogical importance. A leading social thinker in educational practice, Freire rejected the dominant hegemonic view that classroom discourse is a neutral and value-free process removed from the juncture of cultural, historical, social, and political contexts. Freire’s ideas offer several themes of relevance to this discussion, including his banking conception of education, dialog and conscientization, and teaching as a political activity. I attempt to show how these themes can be used to advance a more socially critical and democratic approach to science teaching.
Applications of micropolar SPH in geomechanics
Authors: Zhu Chengwei , Peng Chong , Wu Wei
Published: July 2021

A smoothed particle hydrodynamics code based on micropolar continua for geomaterials is developed for problems involving large deformation and shear strain localization. Two typical geotechnical problems, i.e., biaxial compression test and sand column collapse, are simulated using classical and micropolar model to demonstrate the performance of the newly proposed method. A parameter study is given on the scale effect in the micropolar continua.
Unsaturated structured soils: constitutive modelling and stability analyses
Authors: Rotisciani G. M. , Desideri A. , Amorosi A.
Published: July 2021

The paper presents a new single-surface elasto-plastic model for unsaturated cemented soils, formulated within the critical state soil mechanics framework, which should be considered as an extension to unsaturated conditions of a recently proposed constitutive law for saturated structured soils. The model has been developed with the main purpose of inspecting the mechanical instabilities induced in natural soils by bond degradation resulting from the accumulation of plastic strains and/or the changes in pore saturation. At this scope, the constitutive equations are used to simulate typical geotechnical testing conditions, whose results are then analysed in light of the controllability theory. The results of triaxial tests on an ideal fully saturated cemented soil and on the corresponding unsaturated uncemented one are first discussed, aiming at detecting the evidence of potentially unstable conditions throughout the numerical simulations. This is followed by similar analyses considering the combined effects of both the above features. For each analysed case, a simple analytical stability criterion is proposed and validated against the numerical results, generalizing the results, and highlighting the crucial role of state variables and model parameters on the possible occurrence of failure conditions.
Grounding semantic transparency in context
Authors: Varvara Rossella , Lapesa Gabriella , Padó Sebastian
Published: July 2021

We present the results of a large-scale corpus-based comparison of two German event nominalization patterns: deverbal nouns in -ung (e.g., die Evaluierung, ‘the evaluation’) and nominal infinitives (e.g., das Evaluieren, ‘the evaluating’). Among the many available event nominalization patterns for German, we selected these two because they are both highly productive and challenging from the semantic point of view. Both patterns are known to keep a tight relation with the event denoted by the base verb, but with different nuances. Our study targets a better understanding of the differences in their semantic import.

The key notion of our comparison is that of semantic transparency, and we propose a usage-based characterization of the relationship between derived nominals and their bases. Using methods from distributional semantics, we bring to bear two concrete measures of transparency which highlight different nuances: the first one, cosine, detects nominalizations which are semantically similar to their bases; the second one, distributional inclusion, detects nominalizations which are used in a subset of the contexts of the base verb. We find that only the inclusion measure helps in characterizing the difference between the two types of nominalizations, in relation with the traditionally considered variable of relative frequency (Hay, 2001). Finally, the distributional analysis allows us to frame our comparison in the broader coordinates of the inflection vs. derivation cline.
Between Punishment and Care: Autonomous Offenders Who Commit Crimes Under the Influence of Mental Disorder
Authors: Hartvigsson Thomas
Published: July 2021

The aim of this paper is to present a solution to a problem that arises from the fact that people who commit crimes under the influence of serious mental disorders may still have a capacity to refuse treatment. Several ethicists have argued that the present legislation concerning involuntary treatment of people with mental disorder is discriminatory and should change to the effect that psychiatric patients can refuse care on the same grounds as patients in somatic care. However, people with mental disorders who have committed crimes and been exempted from criminal responsibility would then fall outside the scope of criminal justice as well as that of the psychiatric institutions if they were to refuse care. In this paper, I present and develop a solution to how society should deal with this group of people, called Advance criminal responsibility. The basic idea being that if a person with a potentially responsibility exempting psychiatric condition refuses care, that person is responsible for any future criminal acts which are due to the mental disorder.
$$H^1$$ solutions for a Kuramoto–Sinelshchikov–Cahn–Hilliard type equation
Authors: Coclite Giuseppe Maria , di Ruvo Lorenzo
Published: July 2021

The Kuramoto–Sinelshchikov–Cahn–Hilliard equation models the spinodal decomposition of phase separating systems in an external field, the spatiotemporal evolution of the morphology of steps on crystal surfaces and the growth of thermodynamically unstable crystal surfaces with strongly anisotropic surface tension. In this paper, we prove the well-posedness of the Cauchy problem, associated with this equation.
Two degrees and the SDGs: a network analysis of the interlinkages between transnational climate actions and the Sustainable Development Goals
Authors: Coenen Johanna , Glass Lisa-Maria , Sanderink Lisa
Published: July 2021

Given the interconnectedness of climate change and sustainable development, policymakers and scholars have started to investigate how climate actions can contribute to achieving the Sustainable Development Goals (SDGs), and vice versa. To date, research has mainly focused on the national and international levels, while little is known about the interlinkages between climate actions and the SDGs at the transnational level. Not only nation states, but also non-state actors undertake ambitious actions designed to reduce greenhouse gas emissions and to promote sustainable development. Using content analysis and network analysis techniques, we examine the interlinkages between the climate actions of 72 transnational initiatives and the 169 targets of the 17 SDGs. We find that actions of 71 initiatives contribute to achieving 16 SDGs, thus generating valuable co-benefits. Besides SDG 13 on climate action and SDG 17 on partnerships for the goals, transnational climate actions frequently address SDGs 9 on industry, innovation and infrastructure, SDG 7 on affordable and clean energy, and SDG 12 on responsible consumption and production. While SDG 3 on good health and well-being and SDG 4 on quality education are barely addressed, SDG 5 on gender equality is not at all covered by transnational climate actions. Additionally, the network reveals that SDG 9 is highly synergistic with many other frequently addressed SDGs and functions as an important connector between them. Finally, our results indicate that transnational initiatives fill a governance gap left by states with regards to SDG 12. Climate initiatives of non-state actors can thus complement state-led actions to implement the Paris Agreement and the SDGs jointly.
Electrical and Mechanical Properties of ZrO2-Y2O3-Al2O3 Composite Solid Electrolytes
Authors: Lubszczyk M. , Wyrwa J. , Wojteczko K. , Pleśniak J. , Bućko M. M. , Rękas M. , Brylewski T.
Published: July 2021

Strategic priorities in the field of hydrogen energy include the design of intermediate-temperature solid oxide fuel cells capable of highly efficient operation in the temperature range of 573–973 K. Consequently, attempts are being made to replace the widely applied cubic zirconia electrolyte with an electrolyte consisting of tetragonal zirconia. The rationale for this approach is that 3Y-TZP exhibits higher mechanical strength and higher electrical conductivity at temperatures below 973 K. The addition of Al2O3in an amount that exceeds its solubility limit in 3Y-TZP has been found to result in increased electrical conductivity and improved mechanical properties. The aim of the study was to synthesize 3-YSZ powder via co-precipitation and use it to obtain composites with a 3Y-TZP matrix and 0.5 mol.% or 1.0 mol.% of Al2O3inclusions. The correlation between these samples' electrical conductivity and resistance to brittle fracture and their phase composition and microstructure was investigated by means of X-ray diffractometry, scanning electron microscopy, electrochemical impedance spectroscopy and Vickers indentation tests. For comparison, the properties of composites with an 8-YSZ matrix and Al2O3inclusions were also investigated. It was determined that the composite based on the 3Y-TZP matrix and containing 0.5 mol.% of Al2O3inclusions can be considered a viable alternative for 8-YSZ electrolytes in IT-SOFC applications.
Do We Still Believe There Is a G-spot?
Authors: Mollaioli Daniele , Sansone Andrea , Colonnello Elena , Limoncin Erika , Ciocca Giacomo , Vignozzi Linda , Jannini Emmanuele A
Published: July 2021

In the field of female sexuality, the existence of the so-called “G-spot” represents a topic still anchored to anecdotes and opinions and explained using non-scientific points, as well as being overused for commercial and mediatic purposes.

Purpose of Review

The scope of this review is to give an update on the current state of information regarding the G-spot and suggesting potential future directions in the research field of this interesting, albeit controversial, aspect of human sexual physiology.

Recent Findings

From evolutionary, anatomical, and functional points of view, new evidence has rebutted the original conceptualization of the G-spot, abandoning the idea of a specific anatomical point able to produce exceptional orgasmic experiences through the stimulation of the anterior vaginal wall, the site where the G-spot is assumed to be. From a psychological perspective, only few findings to date are able to describe the psychological, behavioral, and social correlates of the pleasure experience by G-spot-induced or, better, vaginally induced orgasm (VAO).

Recent literature suggests the existence of a G-spot but specifies that, since it is not a spot, neither anatomically nor functionally, it cannot be called G, nor spot, anymore. It is indeed a functional, dynamic, and hormone-dependent area (called clitorourethrovaginal, CUV, complex), extremely individual in its development and action due to the combined influence of biological and psychological aspects, which may trigger VAO and in some particular cases also female ejaculation (FE).
Impact of Increased Hemoglobin on Spontaneous Intracerebral Hemorrhage
Authors: Lu Yuxuan , Jin Haiqiang , Zhao Yuhua , Li Yuxian , Xu Jun , Tian Jiayu , Luan Xiaoting , Chen Siwei , Sun Wei , Zhang Shouzi , Xu Shunliang , Zhu Feiqi , Chen Luzeng , Mima Dunzhu , Sun Yongan , Zhuoga Cidan
Published: July 2021

Background

Studies of the impact of increased hemoglobin on spontaneous intracerebral hemorrhage (ICH) are limited. The present study aimed to explore the effect of increased hemoglobin on ICH.

Methods

A retrospective single-center study using medical records from a database processed by univariate and multivariate analyses was performed in the People’s Hospital of Tibet Autonomous Region in Lhasa, Tibet, China.

Results

The mean hemoglobin level in 211 patients with ICH was 165.03 ± 34.12 g/l, and a median hematoma volume was 18.5 ml. Eighty-eight (41.7%) patients had large hematomas (supratentorial hematoma ≥ 30 ml; infratentorial hematoma ≥ 10 ml). No differences in ICH risk factors between the groups with different hemoglobin levels were detected. Increased hemoglobin was independently associated with large hematomas [odds ratio (OR) 1.013, P = 0.023]. Increased hemoglobin was independently associated with ICH with subarachnoid hemorrhage (OR 1.014, P = 0.016), which was more pronounced in men (OR 1.027, P = 0.002). Increased hemoglobin was independently associated with basal ganglia hemorrhage and lobar hemorrhage in men (OR 0.986, P = 0.022; OR 1.013, P = 0.044, respectively) but not in women (P > 0.1).

Conclusions

Increased hemoglobin was independently associated with large hemorrhage volume. Increased hemoglobin was independently associated with lobar hemorrhage in men and ICH with subarachnoid hemorrhage, which was more pronounced in men. Additional studies are needed to confirm our findings and explore potential mechanisms.
Experimental investigation of a low-molecular-weight polymer coating agent for deep-sea oil and gas drilling
Authors: Ren Xiaoxia , Liu Ran , Ma Zhe
Published: July 2021

In order to solve the problems due to the thickening of drilling fluids at low temperatures caused by the use of high-molecular-weight polymer coating agents in offshore deep-sea oil and gas drilling, a low-molecular-weight polymer coating agent named PADA was synthesized with acrylamide, methacryloxyethyltrimethyl ammonium chloride, and 2-acrylamido-2-methyl propane sulfonic acid. The PADA polymer was characterized with Fourier transform infrared spectroscopy and gel permeation chromatography. The shale inhibition effects of the PADA polymer and associated mechanisms were investigated by shale recovery and expansion experiments, transmission electron microscopy observation, particle size and zeta potential analysis, and interlayer spacing measurements. In addition, the effects of the coating agent on the filter cakes and the low temperature rheological properties of bentonite mud were also tested, and the polymer biodegradability was evaluated. The results showed that the molecular weight of the PADA polymer was 265,000 D, which was significantly lower than that of the traditional coating agents. The PADA had similar effects as two typical commercial products CAP and HPAM on inhibiting the hydration dispersion of shales and performed better than another product PAM. The inhibition effect was achieved by the polymer absorption onto the clay particles through both hydrogen bonding and the electrostatic interactions. The viscosity of bentonite mud containing PADA was much lower than that of mud with other coating agents at 4 °C, so the serious thickening caused by traditional coating agents at a low temperature could be avoided. In addition, it is relatively easily biodegraded.
Inversion-free geometric mapping construction: A survey
Authors: Fu Xiao-Ming , Su Jian-Ping , Zhao Zheng-Yu , Fang Qing , Ye Chunyang , Liu Ligang
Published: July 2021

A geometric mapping establishes a correspondence between two domains. Since no real object has zero or negative volume, such a mapping is required to be inversion-free. Computing inversion-free mappings is a fundamental task in numerous computer graphics and geometric processing applications, such as deformation, texture mapping, mesh generation, and others. This task is usually formulated as a non-convex, nonlinear, constrained optimization problem. Various methods have been developed to solve this optimization problem. As well as being inversion-free, different applications have various further requirements. We expand the discussion in two directions to (i) problems imposing specific constraints and (ii) combinatorial problems. This report provides a systematic overview of inversion-free mapping construction, a detailed discussion of the construction methods, including their strengths and weaknesses, and a description of open problems in this research field.
Recent surging event of a glacier on Geladandong Peak on the Central Tibetan Plateau
Authors: Xu Junli , Shangguan Donghui , Wang Jian
Published: July 2021

Few surges on the Central Tibetan Plateau have been reported. Here, we report observations of a recent surging event of the Gangjiaquba Glacier in the Geladandong Peak region using surface velocity and morphology changes that were extracted from Landsat MSS/TM/ETM+/OLI images obtained from 1973 to 2019. The results reveal that the active surge of this glacier initiated at the end of summer in 2014 and terminated in 2016. The surge resulted in a total advance of 500 ± 11.2 m and many fresh crevasses in the surging zone. The maximum velocity was 1100 m a−1during the active surge phase, which is much smaller than those observed in Karakoram but similar to observations in West Kunlun.
Effect of relative humidity on hydrogen peroxide production in water droplets
Authors: Dulay Maria T. , Huerta-Aguilar Carlos Alberto , Chamberlayne Christian F. , Zare Richard N. , Davidse Adriaan , Vukovic Sinisa
Published: July 2021

Mist is generated by ultrasonic cavitation of water (Fisher Biograde, pH 5.5–6.5) at room temperature (20–25 °C) in open air with nearly constant temperature (22–25 °C) but varying relative humidity (RH; 24–52%) over the course of many months. Water droplets in the mist are initially about 7 μm in diameter at about 50% RH. They are collected, and the concentration of hydrogen peroxide (H2O2) is measured using commercial peroxide test strips and by bromothymol blue oxidation. The quantification method is based on the Fenton chemistry of dye degradation to determine the oxidation capacity of water samples that have been treated by ultrasonication. It is found that the hydrogen peroxide concentration varies nearly linearly with RH over the range studied, reaching a low of 2 parts per million (ppm) at 24% RH and a high of 6 ppm at 52% RH. Some possible public health implications concerning the transmission of respiratory viral infections are suggested for this threefold change in H2O2 concentration with RH.
Risk, Reward, and Scientific Ontology: Reply to Bryant, Psillos, and Slater
Authors: Chakravartty Anjan
Published: July 2021

Scientific Ontology: Integrating Naturalized Metaphysics and Voluntarist Epistemology contends that ontological commitments associated with scientific inquiry are infused with philosophical commitments. Interpretations of scientific ontology involve (what I call) metaphysical inferences, and furthermore, there are different ways of making these inferences, on the basis of different but nonetheless rational epistemic stances. If correct, this problematizes any neat distinction between naturalized and other metaphysics, and dissolves any presumption of there being a uniquely correct answer to ontological questions connected to the sciences. In this paper, I consider some weighty challenges to these contentions by Amanda Bryant, Stathis Psillos, and Matthew Slater.
Larval development of the Caribbean king crabMaguimithrax spinosissimus(Lamarck, 1818), the largest brachyuran in the western Atlantic (Crustacea: Decapoda: Majoidea)
Authors: Turini Tassia , Colavite Jéssica , Bolaños Juan A. , Hernández Jesús Enrique , Baeza Juan Antonio , Santana William
Published: July 2021

The complete larval development of the spider crabMaguimithrax spinosissimus(Lamarck, 1818) is re-described and illustrated in detail from laboratory-reared material. The development consisted of the typical pattern reported for the Majoidea, two zoeal stages and one megalopa. The complete larval development from hatching to first crab lasted 5–6 days at temperatures that ranged between 24–28 °C. Both zoeal stages ofM. spinosissimusexhibited moderate reduction in the number of setae in the maxilla and maxillipeds, from the first to the second zoeal stage, when compared with other closely related species.Maguimithrax spinosissimuscan be easily distinguished from other species belonging to the closely related genusMithraxby the (i) setation of the endopod of the maxillule, maxilla and second maxilliped in both zoeal stages; (ii) setation of the scaphognathite of the maxilla in the first zoeal stage; (iii) setation of the basis of maxilliped I in the second zoeal stage and megalopa; (iv) morphology of the antennule and antenna in the second zoeal stage; and (v) setation of the antennule, coxal endite of maxilla, and exopod of second maxilliped in the megalopa. All these characters support the recent generic status ofMaguimithraxwithin the Mithracidae. Additional morphological details, not available previously, are provided. This study will provide support for conservation strategies in this species.
IL LAVORO E L'ORGANIZZAZIONE DEL CANTIERE NELLA ROMA PAPALE E IMPERIALE. LA BASILICA DI SAN PIETRO E IL COMPLESSO DI DOMIZIANO: FONTI MODERNE PER RICOSTRUIRE PROGETTI ANTICHI
Authors: Sommaini Fabrizio
Published: July 2021

Sin dai primi studi sul cantiere e sul processo costruttivo delle architetture antiche, esempi storicamente ben documentati di età medievale e moderna sono stati presi come riferimento e termine di paragone, al fine di comprendere più approfonditamente l'industria delle costruzioni nell'antica Roma. Questo contributo riflette circa la possibilità di utilizzare due casi di studio parzialmente simili per dimensioni, ubicazione e tecniche costruttive: la Basilica di San Pietro, di età rinascimentale e barocca, in comparazione con l'antico complesso di Domiziano, estensione dei Palazzi Flavi sul Palatino. I primi risultati, che si iscrivono in un progetto di studio sul Complesso domizianeo, aggiungono nuovi elementi alla ricostruzione teorica del cantiere e del ciclo costruttivo. Si analizzano diversi aspetti di questi due progetti architettonici di grandi dimensioni (XXL structures) – la committenza, la forza lavoro, l'approvvigionamento dei materiali da costruzione, l'allestimento del cantiere – evidenziando analogie e differenze, nel tentativo di ovviare alle lacune nella documentazione antica.
Socialization processes within adolescents’ relationships with parents and peers predicting couples’ intimate partner violence in adulthood: A social learning perspective
Authors: Ha Thao , Van Ryzin Mark J. , Elam Kit K.
Published: July 2021

Previous studies have established that individual characteristics such as violent behavior, substance use, and high-risk sexual behavior, as well as negative relationships with parents and friends, are all risk factors for intimate partner violence (IPV). In this longitudinal prospective study, we investigated whether violent behavior, substance use, and high-risk sexual behavior in early adulthood (ages 22–23 years) mediated the link between family conflict and coercive relationship talk with friends in adolescence (ages 16–17 years) and dyadic IPV in adulthood (ages 28–30 years). A total of 998 individuals participated in multimethod assessments, including observations of interactions with parents and friends. Data from multiple reporters were used for variables of interest including court records, parental and self-reports of violence, self-reports of high-sexual-risk behaviors and substance use, and self- and romantic partner-reports of IPV. Longitudinal mediation analyses showed that violent behavior during early adulthood mediated the link between coercive relationship talk with friends in adolescence and dyadic IPV in adulthood. No other mediation paths were found and there was no evidence of gender differences. Results are discussed with attention to the interpersonal socialization processes by which IPV emerges relative to individual risk factors.
Towards a contemporary approach for understanding personality pathology in developmental context: An integrative model
Authors: Altschuler Melody R. , Krueger Robert F.
Published: July 2021

Traditional categorical approaches to classifying personality disorders are limited in important ways, leading to a shift in the field to dimensional approaches to conceptualizing personality pathology. Different areas of psychology – personality, developmental, and psychopathology – can be leveraged to understand personality pathology by examining its structure, development, and underlying mechanisms. However, an integrative model that encompasses these distinct lines of inquiry has not yet been proposed. In order to address this gap, we review the latest evidence for dimensional classification of personality disorders based on structural models of maladaptive personality traits, provide an overview of developmental theories of pathological personality, and summarize the Research Domain Criteria (RDoC) initiative, which seeks to understand underlying mechanisms of psychopathology. We conclude by proposing an integrative model of personality pathology development that aims to elucidate the developmental pathways of personality pathology and its underlying mechanisms.
Relationship of sperm motility with clinical outcome of percutaneous epididymal sperm aspiration–intracytoplasmic sperm injection in infertile males with congenital domestic absence of vas deferens: a retrospective study
Authors: Jixiang Zhong , Lianmei Zhang , Yanghua Zuo , Huiying Xue
Published: July 2021

Congenital domestic absence of vas deferens (CBAVD) is a common factor in male infertility, and percutaneous epididymal sperm aspiration (PESA) combined with intracytoplasmic sperm injection (ICSI) is a primary clinical treatment, but the effect of the sperm obtained on pregnancy outcome remains to be explored. This study aimed to investigate the relationship between sperm motility with clinical outcome of PESA–ICSI in infertile males with CBAVD. A cohort of 110 couples was enrolled. In total, 76 infertile males were included in the high motility group, while the remaining 34 males were placed in the low motility group. Clinical pregnancy, embryo implantation rate and live birth rate were included as the primary outcome. After all follow-ups, we found that the high motility group achieved higher normal fertilization rates, cleavage rates, transplantable embryo rates and high-quality embryo rates than those in low motility group (normal fertilization rate, 78.2 ± 11.7% vs. 70.5 ± 10.2%,P= 0.003; cleavage rate, 97.1 ± 2.9% vs. 92.3 ± 3.0%,P= 0.000; transplantable embryo rate, 66.8 ± 14.9% vs. 58.6 ± 12.6%,P= 0.009 and high-quality embryo rate, 49.9 ± 10.5% vs. 40.5 ± 11.2%,P= 0.000). Additionally, compared with the low motility group, the clinical pregnancy rates, embryo implantation rates, and live birth rates in the high motility group were significantly increased (pregnancy rate, 61.8% vs. 26.5%,P= 0.009; embryo implantation rate, 36.5% vs. 18.0%,P= 0.044; live birth rate, 55.3% vs. 17.6%,P= 0.000). We concluded that the motility of sperm obtained by PESA affected the clinical outcome of ICSI in infertile males with CBAVD.
Effects of the COVID-19 Pandemic on the Intimate Partner Violence and Sexual Function: A Systematic Review
Authors: Bazyar Jafar , Chehreh Razhan , Sadeghifar Jamil , Karamelahi Zolaykha , Ahmadimazhin Sadegh , Vafery Younes , Daliri Salman
Published: July 2021

Introduction:

The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), or coronavirus disease 2019 (COVID-19), has affected many people in the world and has impacted the physical, social, and mental health of the world population. One of these psychological consequences is intimate partner violence affecting sexual health.

Methods:

This study was performed as a systematic review on the effect of the SARS-CoV-2 pandemic on sexual function and domestic violence in the world. Accordingly, all English-language studies conducted from the beginning of the SARS-CoV-2 pandemic to the end of 2020 were extracted by searching in the Scopus, Web of Science, PubMed (including Medline), Cochrane Library, and Science Direct databases and then reviewed. The quality of the articles was assessed using the STROBE checklist.

Results:

A total of 11 studies were included in the systematic review. Accordingly, domestic violence during the exposure to COVID-19 had increased. Moreover, the mean scores of sexual function and its components had reduced at the time of exposure to the pandemic compared to before.

Conclusion:

Given the potential long-term effects of the coronavirus crisis and the large population being affected by this disease, strategies to promote sexual health and fertility of families to prevent or further reduce violence and sexual functions should be chosen.
Scattering Matrix Determination in Crystalline Materials from 4D Scanning Transmission Electron Microscopy at a Single Defocus Value
Authors: Findlay Scott D. , Brown Hamish G. , Pelz Philipp M. , Ophus Colin , Ciston Jim , Allen Leslie J.
Published: July 2021

Recent work has revived interest in the scattering matrix formulation of electron scattering in transmission electron microscopy as a stepping stone toward atomic-resolution structure determination in the presence of multiple scattering. We discuss ways of visualizing the scattering matrix that make its properties clear. Through a simulation-based case study incorporating shot noise, we shown how regularizing on this continuity enables the scattering matrix to be reconstructed from 4D scanning transmission electron microscopy (STEM) measurements from a single defocus value. Intriguingly, for crystalline samples, this process also yields the sample thickness to nanometer accuracy with no a priori knowledge about the sample structure. The reconstruction quality is gauged by using the reconstructed scattering matrix to simulate STEM images at defocus values different from that of the data from which it was reconstructed.