bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, Synthesis, Docking, Characterization and Biological Screening of Novel Azetidinone Derivatives of Nicotinic Acid
Authors: Sivaperuman Amuthalakshmi , Natarajan Ramalakshmi , Subramani Arunkumar , Angamuthu Prabakaran
Published: September 2021

Background:

The prevailing multiple drug resistance among the bacterial species is alarmingly rising day to day, becoming a global threat. Many infectious diseases have become untreated due to the development of resistance in bacterial species, which have a considerable impact on mortality.

Methods:

In this present study, we aimed to synthesize a series of 12 compounds [S1-S12], which are azetidinone derivatives of nicotinic acid. The in vitro antibacterial studies were performed against certain species of gram-negative and gram-positive bacteria. Molecular docking studies were performed to identify the affinity towards the target protein. The antioxidant study was also performed for the synthesized compounds.

Results:

All the synthesized compounds exhibited moderate to potent antibacterial activity with a MIC range of 9.8-21.6 μgmL-1, compounds were active against all tested micro-organisms. The compounds substituted with electron-donating groups like hydroxyl showed higher antioxidant activity compared to others. Docking studies were performed on the active site of DNA gyrase [PDBID: 5L3J,2XCT, 1W7Q].

Conclusion:

The present study reveals that the compounds synthesized exhibit very good antimicrobial activity and antioxidant activity. Therefore, these compounds may be used as a lead for the anticancer, anti-tubercular and other chemotherapeutic agents in future studies.
Implementation of an Electronic Patient-Reported Outcome App for Health-Related Quality of Life in Breast Cancer Patients: Evaluation and Acceptability Analysis in a Two-Center Prospective Trial
Authors: Graf Joachim , Sickenberger Nina , Brusniak Katharina , Matthies Lina Maria , Deutsch Thomas M , Simoes Elisabeth , Plappert Claudia , Keilmann Lucia , Hartkopf Andreas , Walter Christina Barbara , Hahn Markus , Engler Tobias , Wallwiener Stephanie , Schuetz Florian , Fasching Peter A , Schneeweiss Andreas , Brucker Sara Yvonne , Wallwiener Markus
Published: September 2021

Background

One in eight women is diagnosed with breast cancer in the course of their life. As systematic palliative treatment has only a limited effect on survival rates, the concept of health-related quality of life (HRQoL) was developed for measurement of patient-centered outcomes. Various studies have already demonstrated the reliability of paper-based patient-reported outcome (pPRO) and electronic patient-reported outcome (ePRO) surveys and that the 2 means of assessment are equally valid.

Objective

The aim of this study was to analyze the acceptance and evaluation of a tablet-based ePRO app for breast cancer patients and to examine its suitability, effort, and difficulty in the context of HRQoL and sociodemographic factors.

Methods

Overall, 106 women with adjuvant or advanced breast cancer were included in a 2-center study at 2 major university hospitals in Germany. Patients were asked to answer HRQoL and PRO questionnaires both on a tablet on-site using a specific eHealth assessment website and on paper. The suitability, effort, and difficulty of the app and self-reported technical skills were also assessed. Only the results of the electronically acquired data are presented here. The results of the reliability of the pPRO data have already been published elsewhere.

Results

Patients regarded the ePRO assessment as more suitable (80/106, 75.5%), less stressful (73/106, 68.9%), and less difficult (69/106, 65.1%) than pPRO. The majority of patients stated that ePRO assessment improves health care in hospitals (87/106, 82.1%). However, evaluation of ePROs depended on the level of education (P=.003) in the dimensions of effort and difficulty (regression analysis). The app was rated highly in all categories. HRQoL data and therapy setting did not show significant correlations with the app’s evaluation parameters.

Conclusions

The results indicate that ePRO surveys are feasible for measuring HRQoL in breast cancer patients and that those patients prefer ePRO assessment to pPRO assessment. It can also be seen that patients consider ePRO assessment to improve hospital health care. However, studies with larger numbers of patients are needed to develop apps that address the needs of patients with lower levels of education and technical skills.
Can Real-time Computer-Aided Detection Systems Diminish the Risk of Postcolonoscopy Colorectal Cancer?
Authors: Madalinski Mariusz , Prudham Roger
Published: September 2021

The adenoma detection rate is the constant subject of research and the main marker of quality in bowel cancer screening. However, by improving the quality of endoscopy via artificial intelligence methods, all polyps, including those with the potential for malignancy, can be removed, thereby reducing interval colorectal cancer rates. As such, the removal of all polyps may become the best marker of endoscopy quality. Thus, we present a viewpoint on integrating the computer-aided detection (CADe) of polyps with high-accuracy, real-time colonoscopy to challenge quality improvements in the performance of colonoscopy. Colonoscopy for bowel cancer screening involving the integration of a deep learning methodology (ie, integrating artificial intelligence with CADe systems) has been assessed in an effort to increase the adenoma detection rate. In this viewpoint, a few studies are described, and their results show that CADe systems are able to increase screening sensitivity. The detection of adenomatous polyps, which are associated with a potential risk of progression to colorectal cancer, and their removal are expected to reduce cancer incidence and mortality rates. However, so far, artificial intelligence methods do not increase the detection of cancer or large adenomatous polyps but contribute to the detection of small precancerous polyps.
A Venomics Approach to the Identification and Characterization of Bioactive Peptides From Animal Venoms for Colorectal Cancer Therapy: Protocol for a Proof-of-Concept Study
Authors: Shahzadi Syeda Kiran , Karuvantevida Noushad , Banerjee Yajnavalka
Published: September 2021

Background

Cancer is the third leading cause of death in the United Arab Emirates (UAE), after cardiovascular diseases and accidents. In the UAE, colorectal cancer (CRC) is the first and fourth most common cancer in males and females, respectively. Several treatment modalities have been employed for cancer treatment, such as surgery, radiotherapy, chemotherapy, hormone replacement therapy, and immunotherapy. These treatment modalities often elicit adverse effects on normal cells, causing toxic side effects. To circumvent these toxicities, there has been an increased impetus towards the identification of alternate treatment strategies. Animal venoms are rich sources of pharmacologically active polypeptides and proteins.

Objective

In this proof-of-concept study, we will apply a high-throughput venomics strategy to identify and characterize anticancer bioactive peptides (BAPs) from 20 different animal venoms, specifically targeting CRC. We chose to focus on CRC because it is one of the foremost health issues in the UAE.

Methods

In the initial study, we will screen 2500 different peptides derived from 20 different animal venoms for anticancer activity specifically directed against 3 CRC cell lines and two control cell lines employing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay for cytotoxicity. Of the 20 venoms, 3 that exhibit specific and potent anticancer activity directed against the 3 CRC cell lines will be selected; and from these 3 venoms, the specific peptides with anti-CRC activity will be isolated and characterized.

Results

This study is at the protocol development stage only, and as such, no results are available. However, we have initiated the groundwork required to disseminate the proposed study, which includes culturing of colorectal cancer cell lines and preparation of venom screens.

Conclusions

In summary, the proposed study will generate therapeutic leads to manage and treat one of the leading health issues in the UAE, namely, CRC.

International Registered Report Identifier (IRRID)

PRR1-10.2196/31128
The Impact of Mobile Application Systems Use on Mental Health Outcomes: A Secondary Analysis of the Effect of Systems Usage on Anxiety, Worry, & Emotional Reactivity Among Participants in the Unwinding Anxiety Program (Preprint)
Authors: Nardi William , Roy Alexandra , Dunsiger Shira , Brewer Judson
Published: September 2021

BACKGROUND

Mobile health applications provide a promising avenue to help mitigate the burden on mental health services by complimenting therapist-led treatments for anxiety. However, it remains unclear how specific systems' use of application components (i.e., tools) may be associated with changes in clinical symptomatology (i.e., anxiety, worry).

OBJECTIVE

This study was a secondary analysis of systems usage data from the Stage I randomized controlled trial testing the impact of the Unwinding Anxiety mobile application among adults with GAD. This secondary analysis was conducted to assess how using specific application tools may be associated with improvements in anxiety, worry, emotional regulation, and interoceptive awareness.

METHODS

We present analyses of the intervention group (i.e., those who received the Unwinding Anxiety program) during the Stage 1 trial. Total use of specific mobile application tools (i.e., ecological tools, meditation practices, educational modules) as well use specific to each tool (e.g., stress meter, lovingkindness meditation practice) were calculated. We utilized multivariate linear models to investigate the effect of total use of these tools on anxiety, worry, interoceptive awareness, emotional regulation at 2-months post-program initiation controlling for baseline scores, age, and education level. In addition, associations between systems usage metrics and baseline participant characteristics were assessed for differences in usage groupings.

RESULTS

The sample was primarily female (n=25; 92.6%) and the average age was 42.9 years old (SD=15.6) and educational module completion, the central intervention component, averaged 20.2 + 11.4 modules out of XXX for the total sample. Multivariate models revealed that completing >75% of the program was associated with an average 22.6-point increase in interoceptive awareness (SE=8.32, p=0.013) and an 11.6-point decrease in worry (SE=4.12, p=0.009). In addition, a single log unit change in total number of meditations was associated with a 0.95-point reduction in GAD-7 scores (SE=0.27, p=0.005) while a single log unit use of the stress meter was associated with an average of a 0.5-point increase in emotional regulation scores (FFMQ) (SE=0.21, p=0.027).

CONCLUSIONS

The work presented offers a clearer understanding of the impact of specific mobile app systems use on mental health outcomes. In addition, this research lays the groundwork for future comprehensive investigations of systems usage in dosing studies for health behavior change.

CLINICALTRIAL

Developing a Novel Digital Therapeutic for the Treatment of Generalized Anxiety Disorder (NCT03683472).
Cost-effectiveness of AI in medicine from a clinical, technical, and economic perspective: A scoping review and a framework of analysis (Preprint)
Authors: Gomez Rossi Jesus , Feldberg Ben , Krois Joachim , Schwendicke Falk
Published: September 2021

BACKGROUND

Research and Development (R&D) of Artificial Intelligence (AI) in medicine involve clinical, technical and economic aspects. Better understanding the relationship between these dimensions seems necessary to coordinate efforts of R&D among stakeholders.

OBJECTIVE

To assess systematically existing literature on the cost-effectiveness of Artificial Intelligence (AI) from a clinical, technical and economic perspective.

METHODS

A systematic literature review was conducted to study the cost-effectiveness of AI solutions and summarised within a scoping framework of health policy analysis developed to study clinical, technical and economic dimensions.

RESULTS

Of the 4820 eligible studies, 13 met the inclusion criteria. Internal medicine and emergency medicine were the most studied clinical disciplines. Technical R&D aspects have not been uniformly disclosed in the studies we analysed. Monetisation aspects such as payment models assumed have not been reported in the majority of cases.

CONCLUSIONS

Existing scientific literature on the cost-effectiveness of AI currently does not allow to draw conclusive recommendations. Further research and improved reporting on technical and economic aspects seem necessary to assess potential use-cases of this technology, as well as to secure reproducibility of results.

CLINICALTRIAL

Not applicable
A Review of Trusted Research Environments to Support Next Generation Capabilities based on Interview Analysis (Preprint)
Authors: Kavianpour Sanaz , Sutherland James , Mansouri-Benssassi Esma , Coull Natalie , Jefferson Emily
Published: September 2021

BACKGROUND

A Trusted Research Environment (also known as a Safe Haven) is an environment supported by trained staff and agreed processes (principles and standards) providing access to data for research whilst protecting patient confidentially. Accessing sensitive data without compromising the privacy and security of the data is a complex process.

OBJECTIVE

This paper presents the security measures, administrative procedures and technical approaches adopted by TREs.

METHODS

We contacted TRE operators, 20 of whom, in the UK and internationally, agreed to be interviewed remotely under a non-disclosure agreement and to complete a questionnaire about their TRE.

RESULTS

We observed many similar processes and standards which TREs follow to adhere to the Seven Safes principles. The security processes and TRE capabilities for supporting observational studies using classical statistical methods were mature and the requirements well understood. However, we identified limitations in the security measures and capabilities of TREs to support “next-generation” requirements such as wider ranges of data types, the ability to develop artificial intelligence algorithms and software within the environment, the handling of big data, and timely import and export of data.

CONCLUSIONS

We found a lack of software/automation tools to support the community and limited knowledge of how to meet next-generation requirements from the research community. Disclosure control for exporting artificial intelligence (AI) algorithms and software was found to be particularly challenging where there is a clear need for additional controls to support this capability within TREs.
Load Reduction of Floating Wind Turbines Using Tuned Mass Dampers
Authors: Ahmad Aabas
Published: September 2021

Abstract: Offshore wind turbines have the potential to be an important part of the United States’ energy production profile in the coming years. In order to accomplish this wind integration, offshore wind turbines need to be made more reliable and cost efficient to be competitive with other sources of energy. To capitalize on high speed and highquality winds over deep water, floating platforms for offshore wind turbines have been developed, but they suffer from greatly increased loading. One method to reduce loadsin offshore wind turbines is the application of structural control techniques usuallyused in skyscrapers and bridges. Tuned mass dampers are one structural control system that have been used to reduce loads in simulations of offshore wind turbines. This thesis adds to the state of the art of offshore wind energy by developing a set of optimum passive tuned mass dampers for four offshore wind turbine platforms and byquantifying the effects of actuator dynamics on an active tuned mass damper design. The set of optimum tuned mass dampers are developed by creating a limited degree-of-freedom model for each of the four offshore wind platforms
How trade affects the US produce industry: the case of fresh tomatoes
Authors: Li Sheng , Wu Feng , Guan Zhengfei , Luo Tianyuan
Published: September 2021

The US produce industry faces intensifying competition from imports, particularly those from Mexico, the largest exporter of produce to the United States. Fresh produce imports from Mexico have grown dramatically in recent years. This study examines the impact of increasing fresh tomato imports from Mexico on market price and revenue of US growers. Results show that tomato prices are highly sensitive to supply, suggesting a saturated market. Imports from Mexico have significant negative impacts on the prices of US domestic tomatoes. A scenario of 50% increase in tomato imports from Mexico could result in a $252 million (27%) revenue loss for American growers, thus posing great challenges to the sustainability of the declining US tomato industry.
Islamic financial institutions: Performance comparison with Canadian banks
Authors: Gouiaa Raef , Gaspard Pierre-Richard
Published: September 2021

The Canadian financial market is considered to be very conservative and has been using the same practices for a long time. The economies of some countries such as England have adopted a strategy of including Islamic finance in their market and this has produced very satisfactory results. Considering that Islamic finance has been growing in recent years, this type of practice could be relevant to the Canadian market. The objective of this article is to analyze whether the performance of Islamic financial institutions is comparable to traditional banks. A comparison of the efficiency of conventional and Islamic banks will be important to determine because they do not operate in the same way and their primary source of income is different. The results revealed that Islamic banks tended to perform better than conventional banks. Performance ratios were in most cases higher for Islamic banks. This observation was confirmed with the use of the data envelopment analysis (DEA) model, which measures efficiency and effectiveness at the bank level. The results show that although some Islamic banks had significantly fewer assets than conventional banks, they were still able to use resources more efficiently. This confirmed that Islamic finance is an option for Canada and that with government support it will be possible to have a stronger economy overall.
Jenseits von Souveränität und Territorialität: Überlegungen zu einer politischen Theorie der Stadt
Authors: Barbehön Marlon , Haus Michael
Published: September 2021

Zusammenfassung: Seit jeher dienen Städte als Projektionsfläche sowohl für die Identifikation von problematischen Tendenzen der (modernen) Gesellschaft als auch für die Entwicklung erstrebenswerter gesellschaftlicher Zukünfte. Als Kristallisationspunkt und Triebkraft soziopolitischer Entwicklungen nimmt die Stadt eine zentrale Stellung in Praktiken des Regierens und deren Beobachtung ein – und doch tut sich die Politische Theorie traditionell schwer damit, ein Verständnis von Stadt zu entwickeln, das diesem Status und den damit verbundenen Ambivalenzen gerecht wird. Allzu oft verbleiben entsprechende Debatten dem Souveränitätsparadigma verhaftet, sodass die Stadt primär in Relation zum Prinzip territorialstaatlicher Souveränität begriffen wird. Unser Beitrag argumentiert, dass eine Auflösung dieser konzeptionellen Verwicklung dazu beitragen kann, das Verhältnis zwischen dem Städtischen und dem Politischen als ein konstitutionslogisches, das sich von anderen Konstitutionslogiken des Politischen unterscheidet, sichtbar zu machen. Dazu greifen wir auf eine raumtheoretische Perspektive der Moderne zurück, die Stadt und Territorialstaat nicht als „Kleines“ und „Großes“, sondern als zwei eigenständige, zugleich komplementäre und konfligierende Modi der räumlichen Vergesellschaftung begreift. Unser Beitrag zeigt auf, dass Verdichtung und Heterogenisierung, als die beiden wesentlichen raumstrukturellen Merkmale des Städtischen, mit einer spezifischen Konstitution des Politischen im Sinne einer Erzeugung von kollektiver Macht und gesellschaftlicher Ordnung verbunden sind. Die Stadt tritt damit nicht bloß als (austauschbarer) Ort der Materialisierung übergreifender soziopolitischer Phänomene in den Blick, sondern als räumliches Prinzip, das Möglichkeiten für gemeinsames Sprechen und Handeln sowie für Praktiken der konfliktiven Infragestellung hegemonialer Projekte erst hervorbringt. Eine dergestalt angelegte politische Theorie der Stadt erlaubt es, politische Praktiken nicht nur in der Stadt zu lokalisieren, sondern als genuin städtische Phänomene zu erfassen und sowohl die Komplementaritäten als auch die Widersprüche zwischen den Raumprinzipien der Stadt und des souveränen Territorialstaats herauszuarbeiten.
Recht auf die digitale Stadt
Authors: Prien Bernd , Strüver Anke
Published: September 2021

Zusammenfassung: Vor dem Hintergrund der wachsenden Bedeutung der Stadt als Lebensraum wird in der Humangeographie seit 50 Jahren diskutiert, wie sich dieser Raum gerecht gestalten und nutzen lässt. Einen klassischen Beitrag zu dieser Diskussion liefern Henri Lefebvres Überlegungen zum „Recht auf Stadt“ (2016 [1968]). Anlass für unsere aktuelle Beschäftigung mit der Frage ist die zunehmende Digitalisierung städtischer Infrastrukturen und des städtischen Alltagslebens: Dazu gehören erstens die Smart-City-Strategien mit ihren digital gesteuerten Verkehrsleit- und Energieversorgungssystemen etc.; zweitens der sogenannte Plattformurbanismus, der Dienstleistungsaktivitäten plattformbasiert organisiert (z. B. uber, airbnb oder lieferando). In diesem interdisziplinär angelegten Beitrag fragen wir, welche Herausforderungen die in den letzten Jahren zunehmende Durchdringung der Stadt mit digitalen Infrastrukturen und plattformbasierten Ökonomien im Hinblick auf das Recht auf Stadt stellt. Wir argumentieren, dass diese Entwicklungen zu Ungerechtigkeiten führen, und nehmen dafür Nancy Frasers Theorie der Gerechtigkeit und ihr Grundprinzip gleicher Teilhabe zur Hilfe (Fraser 2003; 2009; 2013). Mit der Konzentration auf Frasers These, dass Ungerechtigkeiten der Verteilung und der Anerkennung gemeinsam auftreten, beleuchten wir die Smart City und den Plattformurbanismus. Dabei setzen wir uns kritisch mit bereits existierenden Arbeiten auseinander, um darüber hinausgehend zu zeigen, dass und wie Ungerechtigkeiten in der Dimension der Verteilung und der Anerkennung miteinander wechselwirken.
Einleitung: Die Corona-Pandemie – Praktische Philosophie in Ausnahmesituationen II
Authors: Schweda Mark
Published: September 2021

Zusammenfassung: Die Corona-Krise gibt Anlass zu vielfältigen öffentlichen Debatten, die auch Fragen der Praktischen Philosophie berühren. Entsprechend intensiv fällt die philosophische Auseinandersetzung mit den verschiedenen Aspekten der Covid-19-Pandemie und ihrer individuellen und politischen Bewältigung aus. Dabei lassen sich im Verlauf des Pandemiegeschehens allerdings durchaus Verschiebungen der zentralen Themen, Positionen und Perspektiven beobachten.
Güterabwägung in Zeiten der Covid-19-Pandemie
Authors: Lutz Ronja , Frewer Andreas , Eibauer Cornelia
Published: September 2021

Zusammenfassung: Die Covid-19-Pandemie und der politische Umgang mit ihr beeinflussen sämtliche Bereiche des gesellschaftlichen Lebens auf vielfältige Weise. Ziel dieses Artikels ist es, eine Güterabwägung am Beispiel schwerkranker Kinder und ihrer Familien als vulnerabler Gruppe durchzuführen, um politische Entscheidungen ethisch zu reflektieren. Dafür wird herausgearbeitet, was die Kinderpalliativmedizin im Vergleich zu anderen medizinischen Fachbereichen auszeichnet, und dargestellt, dass ihr Fokus auf der Linderung des „Total Pain“ nach Cicely Saunders liegt. Anhand einer Kasuistik wird ersichtlich, dass die Kinderpalliativmedizin aus diesem Grund durch die vielfältigen Einflüsse der Pandemie auf die physische, psychische, soziale und spirituelle Dimension betreuter Familien vor besondere Herausforderungen gestellt wird. In diesem Zuge wird ebenfalls erläutert, dass Familien mit kinderpalliativmedizinischem Bedarf im Kontext der Covid-19-Pandemie als vulnerable Gruppe angesehen werden können und weshalb die Notwendigkeit einer ausführlichen Güterabwägung besteht. Im Rahmen einer anschließenden ethischen Diskussion wird eine derartige Güterabwägung unter der Einschränkung von Unsicherheit durchgeführt und auf die Problematik der politischen Situation als eines „tragischen Dilemmas“ eingegangen.
Kritik der Biopolitik
Authors: Krach Sebastian
Published: September 2021

Zusammenfassung: Aktuelle Debatten zu gesellschaftspolitischen Folgen der Corona-Pandemie zeigen, dass Intellektuelle wie Giorgio Agamben und Roberto Esposito den Begriff „Biopolitik“ ins Treffen führen, um Regierungsmaßnahmen zur Eindämmung des Virus zu analysieren. Seit Michel Foucaults Überlegungen zur Funktionsweise und Genealogie der Biopolitik birgt der Begriff jedoch eine gewisse Problematik: Aufgrund strukturell bedingter Mechanismen der Inklusion und Exklusion menschlichen Lebens gelingt es den biopolitischen Modellen nach Agamben und Esposito nicht – so die These –, ein zentrales Element des Politischen zu beschreiben. Unberücksichtigt bleibt die Möglichkeit des Widerstands und der Kritik an Regierungsmaßnahmen; eine Möglichkeit, die gerade die Heterogenität politischer Ordnungsstrukturen anzeigt. Im Zuge der Analytik moderner Machttechniken verschiebt Foucault anders als Agamben und Esposito den Fokus von der Biopolitik hin zu einem umfassenderen Paradigma des „Regierens“, der Gouvernementalität. Infolgedessen lässt sich die Biopolitik als Regierungsweise thematisieren, mit der immer schon Formen widerständigen Handelns einhergehen. Um dieser Perspektive Rechnung zu tragen, argumentiert mein Beitrag mit Foucault gegen die primär strukturale Auffassung (bio)politischer Ordnungen nach Agamben und Esposito.
Opportunities for Enhanced Transition of Care Preparation for Adolescents and Emerging Adults With Type 1 Diabetes: Use of the READDY Transition Tool
Authors: Kamoun Camilia L. , Khoury Jane C. , Beal Sarah J. , Crimmins Nancy , Corathers Sarah D.
Published: September 2021

There
is an ongoing need to determine best practices for effective transition from
pediatric to adult care for adolescents and emerging adults EAs with type 1
diabetes given the potential for poor health outcomes post-transfer. This study evaluated self-reported
confidence ratings as measured by the Readiness of Emerging Adults with
Diabetes Diagnosed in Youth (READDY) tool among adolescents and EAs with type 1
diabetes and the association of the confidence ratings with clinical and
demographic characteristics, as well as provider documentation of relevant
anticipatory guidance topics. The READDY is a diabetes-specific tool used to
collect patient-reported confidence in transition preparation topics to target
educational interventions. These interventions are divided into four domains:
Diabetes Knowledge, Health System Navigation, Insulin Self-Management, and
Health Behaviors. A retrospective chart review was conducted of patients 15–24
years of age with type 1 diabetes who completed the READDY between January 2017
and January 2018 at a single center. Overall patient-reported confidence levels
were high. However, adolescents and EAs endorsed their lowest levels of
confidence on items assessing knowledge of alcohol, tobacco, sexual health, and
the impact of diabetes on pregnancy (females only), with the percentages of low
scores of 20.7, 25.9, 35.9, and 42.9%, respectively. Documentation of provider
counseling about screening and prevention of diabetes comorbidities, alcohol
use, and tobacco use was associated with scores in the higher range for the corresponding
item in the READDY. These findings highlight an opportunity to create
interventions related to developmentally important topics for adolescents and EAs
with type 1 diabetes to enhance successful transition preparation.
Penerapan Pajak Terhadap Industri Film Di Masa Pandemi
Authors: Mujitahid Herio , Al Hafizh Halim
Published: September 2021

Taxes are compulsory contributions to the state that are owed by individuals or entities that are compelling based on law, without receiving direct compensation and used for the state’s needs for the greatest prosperity of the people. Tax payments are used to finance state households so that the benefits are felt by the wider community or for the public interest. The film industry is a creative industry engaged in the media, arts and culture. Compared to other creative industry sectors, the film, video and photography industries have the highest creativity and knowledge capital, as forms of intangible assets. Effectiveness means that the goals that have been planned before can be achieved or in other words, the targets are achieved because of the activity process. With the existence of an open letter and protests by the film industry, it has resulted in the provision of relief and incentives from the finance minister for entertainment tax, especially for films.
Analisa Pelaksanaan Tax Amnesty Di Indonesia
Authors: Ayu Mega Sri Deviani Putri Ni Kadek , Dewanti Maheswari Kyara
Published: September 2021

The most inland revenue financed by taxes, especially the state of Indonesia. In increasing state revenue, it can be done by implementing tax amnesty or it’s called tax amnesty.the purpose of this study is to see the influence of knowledge and understanding of the tax amnesty, and to see analysis of the implementation of tax amnesty for three periods. Data analysis technique used is descriptive technique. The results of this study shows that the knowledge and understanding of tax amnesty, and to see analysis of the implementation of tax amnesty for three periods.
Natural (natural resource) capital: development and essential content of the concept
Authors: Polyakov V. V.
Published: September 2021

The capital-forming function of natural resources is currently not questioned within the frame-work of various directions of economic thought. However, the process of realizing their role and place in the reproductive process has a rather long history. In this context, the article presents the author's view on the genesis and development of the concept of natural capital from the first attempts to identify the participation of natural resources in the process of value formation to modern approaches to postulating the essential content of this capital’s form and identifying its constituent elements.
PELATIHAN PEMBUATAN KERIPIK PISANG DAN OPAK MINI PELANGI: INOVASI PRODUK PEMANFAATAN HASIL KEBUN DI DESA MEKAR SARI
Authors: Basri Muhammad , Insani Marzius , Hermawan Roni , Saputri Wulan , Karuniawati Mei , Rahayu Rani , Dewi Nurul Aulia , As’ari Roifan Akib , Pradani Windy , Ramadhani Ardelia Putri
Published: September 2021

Kurangnya minat masyarakat dalam mengolah pemanfaatan hasil kebun, yaitu buah pisang dan singkong di Desa Mekar Sari menunjukkan belum adanya inovasi baru dalam pemanfaatan hasil kebun. Padahal seharusnya bisa menjadi makanan khas desa dan meningkatkan perekonomian masyarakat. Namun, masyarakat Desa Mekar Sari hanya menjual hasil kebun secara langsung kepada para tengkulak tanpa mengolahnya terlebih dahulu menjadi sebuah produk. Hasil kebun seperti pisang dan singkong dapat diolah menjadi sebuah produk seperti keripik dan opak mini pelangi. Inovasi yang dapat dilakukan untuk produk keripik yaitu dari segi bentuk serta rasa yang berbeda dari biasanya. Sedangkan singkong yang di olah menjadi sebuah opak mini diinovasikan dengan berbagai warna. Kegiatan ini bertujuan untuk menghasilkan sebuah inovasi makanan yang bisa dijadikan makanan khas Desa Mekar Sari serta meningkatkan perekonomian masyarakat. Metode yang digunakan dalam kegiatan ini ada 2, yatitu edukasi dan pengembangan serta pengolahan dengan jumlah peserta 20 orang karena masih dalam masa pandemi. Hasil yang diperoleh yaitu masyakat mampu membuat produk keripik pisang dan opak mini pelangi untuk membantu  meningkatkan perekonomian.
Pembuatan Pupuk Kompos dari Limbah Organik Rumah Tangga di Desa Gedung Harapan, Kecamatan Jati Agung, Lampung Selatan
Authors: Aristoteles Aristoteles , Miswar Dedy , Hutauruk Giovanni Albertine , Nadia Ayu Wulandari  , Aditya Prayoga  , A. H. Bernando  , Dyah Mila Prambudiningtyas  , Kurnia Agung Laksono  , Indri Eka Yasami
Published: September 2021

Pengomposan ialah salah satu dari berbagai metode pengolahan sampah organik dimana bertujuan untuk mengurangi dan juga mengubah komposisi sampah menjadi produk yang bermanfaat. Artikel ini berupaya memberikan gambaran dan penjelasan terkait program kerja pembuatan pupuk kompos, meliputi proses, tahapan, hasil, dan manfaatnya. Penulisan artikel ini menggunakan pendekatan kualitatif dengan dengan model deskriptif-eksplanatif. Hasilnya, masyarakat menerima pemahaman dan wawasan baru dalam hal pemanfaatan limbah rumah tangga. Selain itu, masyarakat dapat mengurangi penggunaan pupuk kimia dan pupuk buatan pabrik yang umumnya sudah digunakan oleh masyarakat desa, sehingga dapat meminimalkan pengeluaran masyarakat petani desa dalam proses bercocok tanam. Artikel ini terbatas pada pelaksanaan KKN Mandiri Putra Daerah Periode 1 2021. Artikel ini juga berkontribusi dalam keilmuan pertanian serta praktik dan strategi pengimplementasian poin SDGs.
Analisis Capaian Kinerja Pelaksanaan Anggaran Penerapan Aplikasi Electronic Monitoring Pelaksanaan Anggaran (e-MPA)
Authors: Rosalinda Atikah , Gamayuni Rindu Rika
Published: September 2021

This study aim to examine and found the empirical evidence the consistancy between budget absorption and realization after the implementation of Electronic Monitoring Budget Execution aplication (e-MPA) at Ministry of Religion working unit at Lampung Province. This study use 4.416 population data for the period of 2012 until 2013 before the implementation of e-MPA aplication and the period of 2015 until 2016 after the implementation of e-MPA aplication. Data used are secondary data obtained by accessing the site http://www.kemenag.go.id. The data analyzed using differentiation test with statistical test tool SPSS 22. The result shows that there is a difference of consistancy of budget absorption and there is also a difference on budget realization after the implementation of e-MPA aplication.the difference occured is the decreasing on statistic result of absorption consistancy and absorption realization for budgeting that indicates there is no goal congruence caused by communication pattern, information support, and uncorrect guidelines comprehension for e-MPA aplication.
Agency Cost Influence Toward Dividends Policy at Manufacturing Company Listed in IDX
Authors: Liya Hermawati , Puspita Harsono Edwin
Published: September 2021

Agency intereralation is a manager (agent) that is controlled by others with a contract of one or more shareholder. Manager has their own interest in decision making, but they also have a responsibality to maximize shareholder’s welfare. This conflict of interest always becomes a problem, that is agency problem. To solve this problem, will need some cost, namely agency cost that is related to dividens policy. The interelation between agency and shareholder is a new development to minimize agency cost. The research aims to prove the influence of agency cost towards dividends policy empirically. Dimention used to measure the agency cost is dispertion of ownership, managerial ownership, collateral assets, and debt policy, while dividens policy by dividen payout ratio. Sampling methode applied is purposive sampling, with financial report and company annual report as secondary data used. Sample used in this research is 27 manufacturing companies listed in Indonesia Stock Exchange (IDX) from 2010-2012. Analyzing method used is multiple regression through SPSS ver.16. the outcome of this research is dispertion of ownership, managerial ownership, collateral assets, and debt policy significantly influence in dividens policy partially.
Kinerja Lingkungan dan Tingkat Pengungkapan CSR Sebelum dan Sesudah UU No 47 Tahun 2012
Authors: Putra Fadli Andika , Lindrianasari Lindrianasari
Published: September 2021

Environmental performance and disclosure level of CSR to the enactment of Law No.47 year 2012 is still voluntary. This means companies are not required to disclose environmental performance in the annual report. While in 2012 has been applied new law, then with enactment of the Act environmental performance should be disclosed in the annual report. This study aims to determine how much influence Law No. 47 year 2012 can improve the environmental performance and the level of CSR dsiclosure. There are two variables in this study, ie environmental performance as measured by ISO 14001 certification and CSR disclosure rate measured by GRI4. The number of sample of this study amounted to 640 companies of all companies listed on the BEI in 2008-2015. From the results of research on environmental performance and discloseure level of CSR, positively affect the implementation of Law No.47 year 2012.
PENGARUH CORPORATE GOVERNANCE TERHADAP RESTATEMENT LAPORAN KEUANGAN
Authors: Sembiring Sari Indah Oktanti , Metalia Mega
Published: September 2021

Using independent variable institutional ownership, managerial ownership, independent commissioner, audit committee, and BIG4, this research wanted to see the influence of corporate governance to financial restatement. By using sample of financial report from 2015 until 2017, this research found that institutional ownership is significant but unaccordance with the analyzed hypothesis. And the other independent variable is not significant with financial restatement. This founding may happened because the sample used in this research was not separated between the restated company because of error correction and because of the changes in accounting method that happened because the changes in accounting standard.
Pengaruh Pertumbuhan Ekonomi, PAD, DAU Terhadap Pengalokasian Anggaran Belanja Modal Pada Kabupaten/Kota Sumatera Selatan
Authors: Aryani Putri Retno , Hari Kurnia Krisna
Published: September 2021

This research is aimed at determining the influence ofeconomic growth, local revenue and general fund allocation toward appropriation of capital budget In Districts/City in South Sumatera Province. The samples used in this study were 11 districts/cities in South Sumatera Province in line with the source of Realization Report Budget (APBD) which was accessed from www.djpk.depkeu.go.id and Economic Growth which was obtained from the Central Statistics Agency of South Sumatera Province. The data used in this research was secondary data. The technique of analyzing the data was using multiple regression test.

Simulataneously, the results showed that Economic Growth, Local Revenue and General Fund Allocation had positive significant influence toward capital expenditures. While, partially, the results showed that Economic Growth had no positive significant influence toward toward Capital Expenditure, regional revenue had no positive significant influence toward Capital Expenditure, General Fund Allocation had positive significant toward Capital Expenditure.
Peran Moderasi Konvergensi IFRS Dalam Hubungan Antara Agresivitas Pelaporan Keuangan dan Return
Authors: Suhendro Saring
Published: September 2021

The purpose of this study is to examine the effect of accrual information quality and the role of IFRS convergence on earnings informativeness measured by ERC in relation to stock price movements occurring in Indonesia. Using manufacturing companies that went public and were listed on the Indonesia Stock Exchange in 2004-2013. The use of sample companies in 2004-2007 was before the IFRS convergence and in 2008-2013 after the IFRS convergence. The results showed that earnings response coefficient on earnings information decreased due to reported earnings containing high discretionary accruals. While investor perceptions (ERC) increased after the IFRS convergence.
Analisis Efek Anteseden Struktur Modal Pada Nilai Perusahaan
Authors: Indriani Ruli , Septiyanti Ratna , Kusumaningrum Ninuk Dewi , Syaipudin Usep
Published: September 2021

The research aims to examine the antecedent variables of capital structure, such as profitability, firm size, investment opportunity set, managerial ownership, and dividend policy, and its effect on the firm value. We used 41 listed firms of the Indonesia Stock Exchange from manufacturing industry in 2012-2017 period. We used factor analysis to determine the representativeness of independent variables as the capital structure variables then we tested its effect on firm value by using multiple linear regression. The results indicate that profitability, firm size, investment opportunity set, managerial ownership, and dividend policy simultaneously have a statistically significance influence on capital structure. Partially, profitability has a statistically significance negative effect on capital structure, investment opportunity set has a statistically significance positive effect on capital structure, and managerial ownership has a statistically significancenegative effect on capital structure, while firm size and dividend policy have no statistically effect on capital structure. This research give an empirical evidence that capital structure have a statistically significance positive effect on firm value. This result have an implication that the antecedent effect of capital structure is positive and statistically significance on firm value.
THE EFFECT OF PROFITABILITY AND GOOD CORPORATE GOVERNANCE ON EARNINGS QUALITY
Authors: Aprilian Rani , Andi Kiagus , Amelia Yunia
Published: September 2021

This study aims to examine the effect of profitability and good corporate governance on earnings quality in food and beverage companies listed on Indonesia Stock Exchange (IDX) 2015-2018 period. Profitability is calculated using Return on Assets (ROA). The proxy of Good Corporate Governance are institutional ownership, managerial ownership, audit committee, and independent commissioner. The dependent variable in this study is earnings quality measured by discretionary accrual using Modified Jones Model to detect earning management.

This study used secondary data from the official website of Indonesian Stock Exchange (www.idx.co.id) and the sampling method in this study uses purposive sampling method. The data analysis in this study using multiple linear regression analysis. The results of this study indicate that profitability and audit committee have a positive effect on earnings quality, while the independent commissioner has a negative effect on earnings quality. Other independent variables i.e. institutional ownership and managerial ownership have no significant effect on earnings quality
FAKTOR YANG MEMPENGARUHI PENGUNGKAPAN CSR, SEBUAH STUDY EMPIRIS PERUSAHAAN MANUFAKTUR
Authors: Putri Kurnia , Dharma Fitra , Sukmasari Dewi
Published: September 2021

This studi aims to determine the effect of Board of Commissioners, Profitability, Media Exposure, and Foreign Ownership on CSR disclosure. Population used in this study are manufacturing companies listed on the Indonesia Stock Exchange from 2016-2018, and the samples obtained has 411 observation selected using purposive sampling method in order to obtain samples accordance with the research objectives. Analysis technique used is multiple regression. The result shows that Board of Commissioners, Media Exposure, and Foreign Ownership has a significant positive effect on the Disclosure of Corporate Social Responsibility. While Profitability dosen not affect the Disclosure of Corporate Social Responsibility.
ANALISIS PENGARUH LEVERAGE, PROFITABILITAS, SUKU BUNGA, JUMLAH UANG BEREDAR DAN KURS TERHADAP IHSG
Authors: Komalasari Agrianti , Kananda Husni Bagus , Tidespania Tubarad Chara Pratami
Published: September 2021

This study aims to determine the effect of leverage, profitability, interest rate, money supply, exchange rate against JCI using study case in minning company listed in Indonesia Stock Exchange (IDX) in the period 2013 until 2018. This study is done because seing that there is many factors affecting stock price at the IDX and wants to prove this factors empirically. This study is tested using classic assumption test and hypothesis test. The result shows that leverage, profitability, money supply, exchange rate has a positive effect on IHSG. Interest rate has a negative effect on IHSG.
Cultural and Religious Identity: The Development of Muslim Community at Lembah Baliem “Wamena Papua”
Authors: Helmawati Helmawati , Ismail Rudihartono
Published: September 2021

Islam is the second-largest religion in the world, while in Indonesia Islam is the majority religion adopted by people in Indonesia. However, in some islands such as Papua, Islam is still a minority. This study focused to describe cultural and religious identity especially the Muslim community at Lembah Baliem “Wamena-Papua”. The data on this field research was collected by observation (participative observation) and interview. For cultural anthropology, the research phase in collecting data consisted of observation, recording, verification, and description facts of Muslim Society in Wamena. The focuses of this discussion are the history of the entrance of Muslim in Wamena, how the development of the Muslim community, and how the identity of religion and culture of Muslim community in Wamena.
Suluk as Social Piety: Phenomenological Studies at the Naqsabandiyah Khalidiyah Sufi Order In Sokaraja Banyumas
Authors: Nasrudin Nasrudin
Published: September 2021

Suluk is the most important ritual in the Sufi order by zikr and getting closer to the Creator, usually by leaving the activities public. However, there are data and facts that prove that Suluk actually encourages active efforts to improve the community's social life. The Naqshabandiyah Khalidiyah Sokaraja Banyumas Order is one of the Sufi order that pays attention to suluk, which is carried out in peguron by a spiritual guide for ten to forty days. Consistency in carrying out the practice and discipline will make a pious person mentally-spiritually so that he becomes an example in the social life of the community. Sometimes it creates a negative stigma against Sufi order, but Suluk gives birth the benefits of improving spiritual and social qualities. Suluk is not isolating from social life just for worship absolutely without limits, but becoming a medium of self-purification to become a Muslim who has mental and spiritual readiness to live a better in the midst of social life with social piety.
Model Kepemimpinan Transformasional dan Kontribusinya terhadap Proses Decision Making dan Peningkatan Kinerja Guru di MA Ar-Ridlo Pekuncen Kabupaten Banyumas
Authors: Assegaf Fatimah
Published: September 2021

Abstract

Leadership is a competency that must be owned by madrasah principals. Decision making in educational organizations is directly related to the head of the madrasah. The principal of the madrasah as manager has an important role in making decisions quickly, precisely and effectively by using data and information for optimal educational environmental performance. Decision-making by the head of the MA Ar - Ridlo Pekuncen Banyumas has gone well, this can be seen from the processes and stages carried out by the head of the madrasah in making decisions with observation, data, planning and recording related to education in madrasahs. Then, conduct deliberations with teachers to take policies, take an interpersonal approach to teachers to hold events, give ideas, involve teachers in training, and supervise as supervisory activities. As stated in the teacher work assessment, this is useful for increasing the potential and performance of teachers, to improve the quality of teaching and learning outcomes at MA Ar - Ridlo Pekuncen Banyumas.

Keyword : Principal, Decision-Making, Teachers; Performance, Senior High School