bluuebunny/crossref_metadata_2025 huggingface dataset:
Проблеми та перспективи розвитку бізнес-сектору Чернігівського регіону в умовах війни
Authors:   Національний університет «Чернігівська політехніка», Дерій Жанна , Сакун Олександра ,   Національний університет «Чернігівська політехніка», Полянський Максим ,   Національний університет «Чернігівська політехніка»
Published: October 2024

У статті розглянуто ключові проблеми та виклики, які постали перед бізнес-сектором Чернігівської області в умовах війни. На основі проведеного опитування представників бізнесу Чернігівщини здійснено аналіз стану та потреб для відновлення та розвитку підприємств за такими аспектами, як потреби в персоналі, взаємодія з клієнтами, відносини з державними органами влади та контролю, органами місцевого самоврядування. Було з’ясовано, що ключовими проблемами відновлення та розвитку бізнес-сектору в Чернігівському регіоні є: значні руйнування майна; мінування та пошкодження транспортної інфраструктури; територіальна близькість одночасно до країни-агресора та країни, що підтримує дії агресора; постійний ризик унаслідок обстрілів прикордоння області та ймовірності повторного наступу; руйнування звичних ланцюгів збуту та постачання; дефіцит трудових ресурсів через масове вимушене переміщення населення з прикордонного регіону; низька інвестиційна привабливість області через ризики, пов’язані з прикордонням; дефіцит енергозабезпечення, і як наслідок – часті перебої з електропостачанням та довготривала відсутність електроенергії, що спричиняє простої виробництва, в окремих випадках неможливість дотримання технології тощо.
Сучасний стан та характеристика природно-антропогенних рекреаційно-туристичних ресурсів України
Authors:   Національний університет «Чернігівська політехніка», Алєшугіна Наталія , Зеленська Олена ,   Національний університет «Чернігівська політехніка», Філоненко Ірина ,   Ніжинський державний університет імені Миколи Гоголя
Published: October 2024

У статті систематизовано дані про наявні об’єкти ПЗФ, що використовуються в рекреаційно-туристичній діяльності, а також охарактеризовано інші природно-антропогенні об’єкти, котрі не належать до ПЗФ, але мають рекреаційно-туристичне значення, дано характеристику цих об’єктів як рекреаційно-туристичних ресурсів. Основні результати дослідження отримані шляхом контент-аналізу, узагальнення та систематизації даних з «Державного кадастру територій та об'єктів природо-заповідного фонду» та інших джерел, що знаходяться у вільному доступі. З метою їх інтерпретації використовувались картографічний та хорографічний методи, кількісний та якісний аналіз. Результати дослідження можуть бути використані для створення концепції розвитку та зміцнення туристичного потенціалу територій.
Просторові чинники геопросторового розвитку територіальних громад
Authors:   Харківський національний університет міського господарства імені О. М. Бекетова, Гой Василь , Халіков Сергій ,   Харківський національний університет міського господарства імені О. М. Бекетова, В'яткін Роман ,   Харківський національний університет міського господарства імені О. М. Бекетова, Бурвіков Ігор ,   Харківський національний університет міського господарства імені О. М. Бекетова
Published: October 2024

Доведена актуальність визначення просторових чинників геопросторового розвитку територіальних громад. У результаті дослідження досягнута мета та вирішені завдання. У більшості регіонів визначено посереднє просторове забезпечення. На несуттєвому або незначному рівнях встановлено формування та використання просторового забезпечення територіальних громад у Донецькому та Луганському регіонах. Запропоновані заходи для підвищення ефективності формування та використання просторових чинників щодо забезпечення геопросторового розвитку територіальних громад.
Науково обґрунтовані рекомендації забезпечення інвестиційної привабливості земель регіонів
Authors:   Харківський національний університет міського господарства імені О. М. Бекетова, Багін Михайло
Published: October 2024

Доведено, що зростання значення земельних відносин у сучасній системі місцевого самоврядування, потребує переосмислення підходів до забезпечення інвестиційної привабливості земель на регіональному рівні. У сучасних надзвичайних умовах спостерігається зниження ефективності використання земель, скорочення можливостей залучення інвестицій у сферу земельних відносин, що негативно впливає на розвиток регіонів. Поглиблюють представлені процеси негативний вплив зовнішніх і внутрішніх чинників, наслідки агресії РФ, розбалансування регіональних й стейкхолдерних зв’язків. Для вирішення представлених питань запропоновані науково обґрунтовані рекомендації щодо забезпечення інвестиційної привабливості земель регіонів.
Застосування безпілотних літальних апаратів у будівельній індустрії
Authors:   Freelance consulting, Левщанов Сергій
Published: October 2024

Нові технології, такі як безпілотні літальні апарати (БПЛА), відіграють ключову роль в автоматизації процесів моніторингу та інших операцій у будівельній індустрії. Ця стаття показує огляд за основними напрямками використання БПЛА разом з іншими технологіями в будівництві та експлуатації за останні 5 років. У результаті цієї роботи було вивчено потенціал використання БПЛА в будівельній галузі, і знайдено відповіді на такі запитання: Які переваги використання БПЛА - дронів у будівельній індустрії порівняно з традиційними методами? З якими проблеми та недоліки стикається технологія дронів на шляху її впровадження в будівельну індустрію? Стаття є оглядово-інформаційною.
Effect of nutrient support on structural and functional parameters of facial skin
Authors: Shikch Eugenia   V. , Zhukova Olga   V. , Konstantinova Maria S. , Koliadko Anastasiia S.
Published: October 2024

Background. Aging is a complex biological process of gradual metabolic, structural and functional changes in the body, which can lead to a decline in physical and mental functions, as well as to the development of diseases. At the moment, the issue of anti-aging remains relevant, given the steady increase in life expectancy and the growing proportion of the elderly population, which is observed practically worldwide. Biologically active supplements containing components used as part of complex therapy for the correction and prevention of signs of premature skin aging are becoming increasingly popular.
Aims. To evaluate the effectiveness and safety of taking the dietary supplement VITABEAUTY® Hyaluronic Acid + Resveratrol on the functional parameters of facial skin.
Methods. A simple blind placebo-controlled cross-over study was conducted, involving 40 female patients over 18 years old with signs of aging. The observation was carried out for 10 weeks. The dietary supplement and placebo were taken according to the following scheme: during the first 4 weeks of the study patients received placebo, then the subjects took VITABEAUTY® Hyaluronic Acid + Resveratrol for the next 6 weeks. Objective assessment of skin condition was carried out in 4 and 10 weeks after the beginning of the study in strictly fixed areas of the forehead and cheek. The patients’ subjective evaluation of the effectiveness of the supplement VITABEAUTY® Hyaluronic Acid + Resveratrol also was carried out.
Results. Statistically significant improvement of skin moisture and wrinkle depth was registered at the end of the study at patiens receiving VITABEAUTY® Hyaluronic Acid + Resveratrol. 95% of the subjects evaluated the result of taking the dietary supplement as good and satisfactory.
Conclusion. The obtained results allow us to recommend the dietary supplement VITABEAUTY® Hyaluronic Acid + Resveratrol for regular intake to prevent and/or control the initial signs of skin aging.
Tratamento interdisciplinar na correção do sorriso gengival
Authors: Dionísio Ellen Paula Pereira , Guillou Joyce Quintela Carvalho , Espíndola Laís Christina Pontes
Published: October 2024

Objetivo: Relatar um caso clínico de abordagem interdisciplinar na correção do sorriso gengival. Detalhamento do caso: O presente relato foi submetido ao comitê de ética em pesquisa, sendo aprovado a partir do protocolo de nº CAEE 73608223.8.0000.0122. Paciente, 23 anos, sexo feminino, compareceu à clínica com queixa estética da proporção de seus dentes e gengiva. Ao exame clínico, foi diagnosticado sorriso gengival, sendo realizados exames clínicos e fotográficos complementares, para identificação de etiologia. A mesma foi diagnosticada com erupção passiva alterada e dentes conóides. Foi proposto tratamento interdisciplinar à paciente, sendo então realizado aumento de coroa clínica estético através da técnica flapless para restabelecimento da altura dos tecidos supracrestais, e, após a completa cicatrização tecidual, clareamento dental na técnica de consultório e procedimento restaurador por meio de facetas em resinas compostas.  O correto diagnóstico do sorriso gengival é de extrema importância para a tomada de decisão no tratamento. Diversas terapêuticas, principalmente atuando de forma interdisciplinar, podem ser propostas, e devem ser bem avaliadas para que se possa atingir o resultado mais satisfatório e com maior previsibilidade de sucesso. Considerações finais: O correto diagnóstico do sorriso gengival possibilitou uma abordagem correta, o que possibilitou sucesso no tratamento.
Síndrome de Takotsubo e vacinas contra COVID-19
Authors: Souza Caroline Pereira de , Filho Neto Girnaldo Leônidas Jorge de Sousa , Lamas Alma Graciela González de , Gonçalves Matheus Silva , Steil Bruna Magali , Oliveira Michele Pacheco de , Fernández Viviana Cristina , Queiroga Victória Madalena Silva Honório de , Lima Myllena Cardoso , Gongora Diogenes Durañones
Published: October 2024

Objetivo: Reunir e analisar evidências para entender e correlacionar a influência da síndrome de Takotsubo (TTS) induzida pela vacinação contra a Covid-19. Métodos: Revisão integrativa incluindo artigos publicados entre 2021 e 2024 e selecionados através de acesso a plataformas de publicação científica como Scielo, BVS, PubMed e Elsevier. Foram utilizados os descritores Covid Vaccine e Takotsubo Syndrome. Foram excluídos os artigos que pertenciam à tipologia carta ao editor, opinião de especialista, resposta à opinião, resenhas, capítulos de livro, relatos de casos isolados. Resultados: 13 artigos foram incluídos, dos quais 12 artigos encontraram associação entre a vacinação contra a Covid-19 e a TTS. Existe maior incidência desta complicação produzida pela a vacina de RNA mensageiro (RNAm) em comparação às outras vacinas. Os sintomas mais prevalentes na TTS induzida pela vacinação incluem dor torácica, febre, tosse, dispneia, náuseas e sintomas digestivos. Se evidenciou as alterações eletrocardiográficas (elevação do segmento ST e inversão da onda T) e elevação dos marcadores cardíacos (troponina, CK-MB e NT-proBNP). Os exames de imagem mostraram opacidades em vidro fosco, consolidação pulmonar e aumento da silhueta cardíaca. Considerações finais: É fundamental monitorar os efeitos das vacinas contra a Covid-19 para desenvolver estratégias de prevenção e manejo eficazes.
Análise dos casos de dengue em Itacoatiara-AM e no estado do Amazonas durante e após a pandemia da COVID-19
Authors: Lima Pedro Pinheiro Holanda , Oliveira Kevin Thiago Medeiros de , Rezende Rebeca Cardoso de Oliveira , Delgado Favio Alexandro Andrade , Peixoto Íthalo Felipe da Silva Aranha , Santos Neto Claudio Rabelo dos
Published: October 2024

Objetivo: Analisar os casos de dengue notificados e positivos durante e após a pandemia da COVID-19 no município de Itacoatiara-AM. Métodos: Trata-se de um estudo quantitativo descritivo que investigou a correlação entre casos de dengue durante e após a pandemia da COVID-19 em Itacoatiara-AM e os dados das notificações de casos prováveis de dengue no estado do Amazonas, no período de 2020 a 2023. Aplicou-se o Teste Qui-Quadrado de Pearson para comparar casos notificados e confirmados em Itacoatiara-AM e calculamos o desvio padrão para avaliar a dispersão dos dados, analisando os fatores influenciadores. Resultados: Em Itacoatiara-AM, os casos por ano foram: 2020: 45 notificações, 15 positivos; 2021: 69 notificações, 10 positivos; 2022: 25 notificações, 11 positivos; 2023: 45 notificações, 4 positivos. No estado do Amazonas, em 2020 foram notificados 6052 casos prováveis de dengue, seguidos por 8274 em 2021, 5359 em 2022 e 6356 em 2023. Conclusão: Ainda existem questões que podem ser ampliadas e aprofundadas por novos estudos de forma a compreender melhor sobre os dados levantados em relação ao comportamento, diagnóstico e notificações de casos de dengue no período pandêmico da COVID-19.
Experiência e satisfação de mulheres quanto ao processo de parturição
Authors: Souza Gabriela Mendes de , Oliveira Antonia Gerlene de Lima , Nunes Antonio Eduardo de Sousa , Lopes Amanda Amorim Sales , Fernandes Bruna Emyle Dutra , Lima Liene Ribeiro de , Lima Caroline Ribeiro de , Lima Hilderlania de Freitas
Published: October 2024

Objetivo: Averiguar a experiência e satisfação das mulheres quanto ao trabalho de parto, parto e pós-parto no Sertão Central Cearense. Métodos: Estudo transversal descritivo, com abordagem quantitativa, realizado no Alojamento Conjunto do Hospital Maternidade de referência no Sertão Central Cearense, envolvendo 62 puérperas entrevistadas através do Questionário de Experiência e Satisfação com o Parto (QESP), que avaliou as mulheres durante o trabalho de parto, parto e pós-parto. Os dados foram analisados estatisticamente pelo SPSS, com resultados apresentados por meio de tabelas. Resultados: Participaram 62 puérperas, jovens (25,5 anos), com ensino médio (54,8%), em relacionamento estável (82,2%), atuando em cuidados domésticos (53,2%) e com renda familiar menor que um salário-mínimo (59,7%). Nota-se que 72,6% das mulheres não tinham experiências obstétricas anteriores, e a maioria (79%), compareceu a 8 ou mais consultas de pré-natal e apresentaram intercorrências obstétricas. Conclusão: Observou-se que as puérperas apresentaram uma boa expectativa e satisfação quanto ao processo de parturição em todos os âmbitos que o circundam. O presente estudo destaca sobre a importância do conhecimento das parturientes e da assistência de qualidade para uma experiência positiva do processo de parturição. Esses dados são valiosos para que profissionais e gestores aprimorem a assistência ao parto.
Creation and Expansion of Bioadhesive Transdermal Gel of Levobupivacaine Loaded Nanoparticles for Enhancement of Anesthetic Effect.
Authors: Choudhary Ram Kumar , Patil Anasuya . , Gadekar Ramesh Abhimanyu , Dharmamoorthy G  .
Published: October 2024

The present research work aimed to prepare a bioadhesive gel containing Levobupivacaine-loaded nanoparticles (NPs) to improve local anesthesia as transdermal patches were patient-friendly and easy to therapy. This study focuses on developing a The NPs were created using the ionotropic gelation method and assessed for particle charge, vesicle size and its distribution, and surface morphology. The improved NPs were incorporated into a gel and evaluated for their physicochemical assets. Among the NPs, NP4 was identified as the best based on its physicochemical properties. The NG-6 bioadhesive gel formulation stood out as the top gel among those tested. The NG-6 gel exhibited superior skin permeation ended 14 hours compared to other NPs. This bioadhesive transdermal gel with Levobupivacaine nanoparticles offers a promising approach to enhancing anesthetic effects.
Cytoprotective Effects of Phloretin on Long-Term Post-Prandial Hyperglycemia-induced Esophageal Damage in Rats .
Authors: Pujari Neelkanth M , Khushtar Mohammad , Mishra Anuradha . , Gupta Deepika .
Published: October 2024

Esophageal damage arises from gastroesophageal reflux disease, where the contents of the stomach and duodenum flow back into the esophagus, causing an inflammatory lesion. Phloretin, a phytoconstituent classified as a flavonoid possessing both nutritional and medicinal properties, was the focus of this study. The experiment aimed to investigate the impact of phloretin on experimental esophagitis in albino rats. Rats in various groups underwent the induction of esophagitis through the administration of a Fructose solution (10%) and indomethacin (5mg/Kg). The resulting hyperglycemia from regular Fructose solution intake over 28 days was assessed. After sacrifice, the rats were evaluated for the esophagitis index. Additionally, esophageal tissues underwent further analysis for oxidative stress parameters, including TBARS, SOD, Catalase and GSH. Treatment with phloretin demonstrated a significant inhibition of the esophagitis index. Furthermore, phloretin contributed to the restoration of altered levels of oxidative stress parameters back to normal.
Optimization In-vitro Evaluation and Scratch Wound Healing Assay of Hexacosane Topical Gel for Wound Healing.
Authors: PN Sruthy . , Govindaraj Saravanan .
Published: October 2024

The compounds hexocosane, a sterol hydrocarbon identified in the dichloromethane extract and isolated from marine sponges of the genus Agelas. Hexocosane possesses anti-inflammatory and antioxidant activities that reduce inflammation and oxidative stress, they promote cell proliferation and angiogenesis, facilitating tissue regeneration and repair. This multifaceted approach makes this secondary metabolite a promising candidate for developing advanced wound care therapies that effectively address both infection control and wound healing. On the basis of viscosity, in-vitro release, and skin retention, optimal gel formulations were developed with hexocosane (1%) to achieve the best results. A response surface methodology Box-Behnken design was applied on three factors and three levels [carbopol 940 (1, 1.25 and 1.5%), hydroxypropyl methylcellulose (HPMC) (1,1.5 and 1.2%), and propylene glycol (0–1–1.5% and 1–2%, respectively] using three factors and three levels. In order to assess the spreadability and viscosity, a glass slide and a Brookfield viscometer were used. An assay was conducted to determine how topical gel affects wound healing. The optimization study of the gel formulation, involving variations in adhesive polymer (Carbopol 940), release retarding polymer (HPMC K4M), and penetration enhancer (Surfactant), has identified three noteworthy formulations (F4, F8 & F14). Each formulation is characterized by specific attributes such as viscosity, in-vitro drug release, and skin retention. All samples were found to elicit significant wound healing efficacy as evidenced from the representative photomicrographs. The maximum efficacy was elicited by formulation (F4) with 100 mg drug at the time duration of 36 hours.
Development and Analysis of Colon-Specific, pH-Responsive Polymer Delivery of Irinotecan Hydrochloride Tablets for Colon Cancer Treatment.
Authors: V Mahalekshmi . , N Balakrishnan . , T.V Ajay Kumar , V Parthasarathy .
Published: October 2024

For the formulation of enteric-coated tablets containing irinotecan hydrochloride, this thesis focuses on HPMC and ethylcellulose, both of which are pH- and oxidation-resistant polymers. The integrated polymer-drug tablet mixture was coated with 15% of eudragit S100 and L100, which is a methacrylic acid copolymers, that’s soluble at pH 7. Both the physical characteristics with the invitro release kinetics pattern of the enteric-coated tablets were characterized. In the invitro release study, different pH environments were used, comparable to the gastrointestinal tract (GIT): 0.1 N HCl solution for two hours, pH 6.8 phosphate buffer for three hours, and pH 7.4 phosphate buffer for six hours. Using this device, you can simulate the pH level of the mouth, the digestive tract, and the urinary tract. As a result of consistent release studies, formulation F7 released 88.2% of the drug after 12 hours. Models such as Higuchi, Korsmeyer-Peppas, and zero-order reactions were used to analyze the GIT. This directed the development of a sustained delivery pattern that may be perfect for colonic IRT administration in the eventual treatment of colon cancer. Among the nine formulations, F7 formulated with EC and HPMC extended best sustained release pattern of drug, hence it is suitable for treating colon cancer.
Silver and Iron Nanoparticles: Green Synthesis and Characterization.
Authors: Waykar Ravindra . , Kumarapillai Srinivasakumar .
Published: October 2024

Biosynthesized nanoparticles (NPs) are gaining traction because they leverage physiologically active plant secondary metabolites, enabling eco-friendly synthesis and offering exclusive biological benefits. This innovative nanomedicine technology shows great promise in medicine, providing a novel method for drug delivery and treatment. The advancement of biosynthesized nanomedicine has notable implications for the pharmaceutical and medical sectors, presenting a more precise and effective way to address diseases. This paper introduces a cost-effective, environmentally friendly, and dependable method for synthesizing silver and iron NPs. The method involves employing the aqueous leaf extract of Vallisneria spiralis Linnaeus. The biosynthesized NPs were analyzed utilizing several methods, including transmission electron microscope (TEM), dynamic light scattering (DLS), UV−visible spectroscopy, and ICP-MS.
Development and Evaluation of Voriconazole Loaded Transfersomal Gel for Enhanced Antifungal Activity.
Authors: S Amareshwar . , Sailaja Abbaraju Krishna
Published: October 2024

The BCS class II antifungal drug voriconazole (VRC) has a broad spectrum of action. Its solubility is still a major problem for formulation scientists despite numerous attempts to improve it. The thin-film hydration technique produced the voriconazoleloaded Transfersomes, optimized using the Central Composite Design (CCD) and then included as a gel into Poloxamer 407P. Several parameters were assessed for the prepared VRCT, including particle size, zeta potential, surface shape, potential chemical interaction, and polydispersity index (PI). The SEM study also revealed the appearance and surface of optimized transferosomes are symmetrical. The optimized formulation’s average size was found to be 238.8 nm by the particle size analysis. Similarly, a value of 0.449 was found by the polydispersity index (PI). To evaluate voriconazole Transfersomal gel’s (TG4) antibacterial efficacy, an antimicrobial investigation was conducted. The creation of Transfersomal gel formulation offers a topical drug administration method that is more effective and improves patient compliance.
Teriflunomide Transdermal Cream: In-vitro And In-vivo Evaluation for the Treatment of Rheumatoid Arthritis.
Authors: Sreedharala Venkata Nookaraju , Chintamaneni Pavan Kumar
Published: October 2024

Rheumatoid Arthritis (RA) is an incurable long-term disease that requires continuous safe treatment. Currently, many antiinflammatory agents and steroids are used to manage the diseases and are associated with a variety of side effects. There is a great need for a formulation that addresses the root cause of the disease and can be used for prolonged periods without any side effects. Hence, an attempt was made to develop a formulation of an alternative to steroid formulations that can be used for prolonged periods without/minimal side effects, i.e., teriflunomide topical dosage form. Teriflunomide tablet was approved for multiple sclerosis. It is the primary metabolite of leflunomide which is approved to treat RA. When leflunomide is administered orally converts to teriflunomide to elicit its action as such, leflunomide has no anti-rheumatoid effect. Both leflunomide and teriflunomide have different GIT side effects such as diarrhea, nausea, and hepatotoxicity on oral administration. To avoid these oral side effects of leflunomide and teriflunomide and to improve RA treatment compliance, teriflunomide was formulated as a topical cream. The developed topical cream is designed to be applied at night on the affected joints. It is intended to release the drug during the night, provide higher localized concentrations of the drug in the synovial joint and reduce GI and systemic side effects improving treatment compliance.
Quality by Design Approach to Nasal Mucoadhesive Microspheres: Enhanced Sumatriptan Succinate Delivery through Formulation and Characterization.
Authors: Vyas Shivanee . , N Anitha K , Mudduluru Niranjan Babu , Devhare Lalchand D
Published: October 2024

The primary therapeutic indications for sumatriptan succinate (STS) include the treatment of migraine and cluster headaches. To enhance mucoadhesion, sodium carboxymethyl cellulose (SCMC) and hydroxyl propyl methyl cellulose (HPMC K15M) were used in this study to develop nasal mucoadhesive microspheres of STS. A central composite design, facilitated by Design Expert software, was employed to assess the impact of polymer concentrations on mucoadhesion, involving nine different formulations. The study’s findings indicated that the microspheres were uniformly sized and spherical and that the polymers were compatible with STS. The optimal formulation, consisting of 220.711 mg of SCMC and 150 mg of HPMC K15M, demonstrated the highest level of mucoadhesion. This combination effectively regulated the discharge of STS from the mucoadhesive microspheres and significantly improved their mucoadhesive properties. These results suggest that the strategic use of SCMC and HPMC K15M can enhance the performance of nasal mucoadhesive microspheres, ensuring a controlled release of STS and improved adhesion to mucosal surfaces. This has the potential to optimize the therapeutic efficacy of STS in treating migraine and cluster headaches.
Harnessing the Power of Curcumin: Evaluating Its Efficacy as an Antileishmanial Agent in the Fight Against Leishmaniasis
Authors: Ambilkar Minal Gopichand , Mude Gaurav Sanjay , Kucheriya Aashumi Ashok , Bhoyar Rahul Madhukar
Published: October 2024

Over 100 countries are impacted by the dangerous parasite disease leishmaniasis, which is categorized as a neglected tropical disease (NTD). Protozoan parasites use sandflies and other vectors to spread the disease. Herbal compounds like turmeric curcumin have demonstrated promise in the treatment of parasitic illnesses despite their limited bioavailability and water solubility. From small, self-healing skin lesions to serious intestinal infections, leishmaniasis can cause a wide range of illnesses in humans. Since there isn’t a gold standard test for one type, mucocutaneous leishmaniasis (MCL), it can be difficult to diagnose. Treatments for MCL can be quite harmful, which emphasizes how crucial a correct diagnosis. This study aims to assess the diagnostic performance of PCR (polymerase chain reaction) for MCL and to compare the findings with the authors’ most recent clinical research findings.
Recent Advances and Future Prospects in Polymer-Mediated Drug Delivery Systems: A Comprehensive Review.
Authors: Bharathy Pavithra . , Thanikachalam Punniyakoti V
Published: October 2024

Polymer-based drug carriers have revolutionized the pharmaceutical landscape, providing innovative approaches for efficient drug delivery. These advanced systems have significantly mitigated traditional challenges, offering new avenues for targeted and controlled drug release. This paper aims to explore polymers, focusing on their classification, properties, drug release mechanisms, and pharmaceutical applications while emphasizing recent advancements and future prospects in the field. Polymers can be classified based on their origin, biodegradability, and physical properties. Their unique characteristics, such as biocompatibility, flexibility, and ability to modify surface properties, make them ideal for drug delivery applications. The review delves into various drug release mechanisms employed by polymer-based systems, including diffusion, degradation, swelling, and stimuli-responsive release. These mechanisms ensure a controlled and sustained release of therapeutic agents, enhancing efficacy and reducing side effects. The pharmaceutical applications of polymer-based drug carriers are vast, encompassing targeted delivery to specific tissues or cells, sustained-release formulations, and the delivery of complex molecules like proteins and nucleic acids. Despite their advantages, polymer-based drug delivery systems face limitations, including potential toxicity, stability issues, and manufacturing challenges. Addressing these limitations through continued research and development is crucial for advancing the field. Recent advancements, such as smart polymers and nanotechnology integration, hold promise for overcoming these challenges and improving drug delivery efficiency. In conclusion, polymer-mediated drug delivery systems represent a significant leap forward in pharmaceutical technology. This review highlights the importance of polymers in modern medicine, their potential to revolutionize drug delivery, and the ongoing efforts to optimize their use in clinical applications.
Novel Quantitative Estimation of Rucaparib and Bevacizumab in Rat Plasma Using LC-MS/MS & Study of Pharmacokinetics.
Authors: K Santha Kumari , S Mohan . , K Prasada Rao
Published: October 2024

Rucaparib and Bevacizumab‘s bioanalytical evaluation was performed using an easy-to-use, effective, and repeatable LC-MS/ MS technique, with D6-Rucaparib and D6-Bevacizumab serving as internal standards. This work provides a summary of current developments in bioanalytical LC-MS/MS techniques using an organic mobile phase consisting of 50:50 formic acid and acetonitrile IN 0.1% as well as a Waters Symmetry C18 column. The results for stability, matrix effect, accuracy, precision, and recovery were all within allowable bounds. To test the targeted analytes in body fluids using pharmacokinetic research, a simple and efficient approach was created. This application included all accuracy, system appropriateness, linearity, and specificity characteristics that were used successfully for pharmacokinetic investigations in rats and that complied well with USFDA guidelines.
Stability Indicating LC–ESI-MS/MS Method Development and Validation for the Quantitation of Lurbinectedin in Biological Matrices.
Authors: Anusha Mantravadi . , Gubbiyappa Kumar Shiva
Published: October 2024

The anticancer drug lurbinectedin was measured in plasma samples using a newly designed and validated LC-ESI-MS/MS method. The drug’s examination was conducted using ledipasvir as the internal standard. Following the liquid liquid extraction of 200 μL of plasma, the samples were separated using a ZorbaxSB (25 0mm x4.6 mm, 5 µm)C18 column. The mobile phase comprised of 0.1 %V/V formic acid and acetonitrile in the fraction of 10:90, and an infusion flow rate was 0.80mL/min. The analytes were eluted in 3.5 minutes total. Using a concentration range of 1.50 to 5000ng/mL of lurbinectedin and a correlation coefficient value of 0.9994, the method was validated in compliance with FDA standard standards. Assay accuracy ranged from 95.31% to 104.06% of the nominal values, and both intra- and inter-day precision results were within 4.32%. For the analyte at the LQC level, the matrix factor varies from 94.25% to 104.85% with a %CV of 4.61, whereas at the HQC level, it ranges from 94.62% to 103.88% with a %CV of 4.02. The results of the stability tests show that the approach is quite stable. Regular analysis in bioavailability, quality control, and bioequivalence investigations of biological matrices may be effectively performed using the established approach.
Multi-Path Mechanism of Phytoconstituents in Herbal Remedies for Obesity
Authors: Vyas Ujwal B , Telrandhe Umesh B , Khobragade Deepak
Published: October 2024

Obesity, a metabolic disease with multiple manifestations, has become an epidemic around the world, necessitating efficient and long-term solutions. Since there is an extensive list of phytoconstituents and mechanisms for effective conventional herbal remedies, there has been a lot of focus on potential applications for managing obesity. This study focuses on multiple ways that plant-based compounds in various herbal remedies may help combat obesity. The strategies include modifying adipogenesis, ceasing lipogenesis, accelerating lipolysis, regulating appetite, helping insulin respond more effectively, and altering the gut microbiota. We address the function and clinical evidence of key phytoconstituents from plants like bitter oranges (synephrine), green tea (catechins), and Garcinia cambogia (hydroxycitric acid) in maWe also consider potential complications and explore opportunities for investigating and developing herbal weight loss solutions. We may be able to use plant phytoconstituents as additional treatments or prevent overweight and associated problems by understanding their intricate working methods.
Recent Advancements in Drug Delivery System in Lung Cancer
Authors: Chaudhari Gunjan , Bagga Harprit Kaur , Raghuwanshi Gaurav , Vyas Ujwal
Published: October 2024

Eliminating the fact that the use of free pharmaceuticals in conventional dosage forms usually involves difficulties in hitting the target site at the appropriate dose after or during a correct time period, medication targeting specific organs and tissues became one of the century's most important initiatives. Thus, finding new drug delivery strategies and modes of action are lines of battle. Difficulties are still encountered with radiation therapy to accurately track the movements of lung tumors while treatments are being admitted. The development of MRI-linac hybrid system prototypes offers the possibility of real-time, ionization-free tumor imaging. This study assesses how well lung tumor tracking algorithms function on five healthy participants' cine-MRI sagittal images. The targets were vascular structures that could be seen. Lung cancer is the leading cause of mortality in the world. This is one of the heterogeneous diseases that include, at the basic level, two main subtypes: small cell lung cancer and non-small cell lung cancer. Less than 20% of patients with LC survive for 5 years on average despite recent improvements in treatment. The effectiveness of existing therapeutic techniques is impaired because of severe off-target effects and innate or acquired medication resistance. The two major types of lung cancers are SCLC and NSCLC; among these, the former is the most frequently diagnosed. Lung cancers account for the highest mortality rate due to cancer. The application of nanomedicines can partially overcome the failures that are associated with the anticancer therapies against NSCLC. One of the nanoparticle subfields that hold out much promise for better delivery while ensuring stability and sufficient bioavailability of administered anticancer medications is nanomedicine.
Effects of Alpha-Tocopherol (Vitamin E) Treatment on Cardiovascular Biomarkers: A Comprehensive Review
Authors: Patel Bhoomika , Prakasam Anita , V Suresh , Patel Bhavisha , Hadia Rajesh
Published: October 2024

This comprehensive review explores that subjoining of alpha-tocopherol (vitamin E) have improved effect on
cardiovascular biomarkers in the human subjects, focusing on its potential role in addressing cardiovascular diseases
(CVDs), which are major global health challenges exacerbated by risk factors such as dyslipidaemia and hypertension.
Systematic analysis of various randomized controlled trials, evaluates alpha-tocopherol's effects on LDL cholesterol, HDL
cholesterol, systolic blood pressure, triglycerides, total cholesterol levels etc. The synthesis of current literature consistently
indicates that alpha-tocopherol treatment leads to significant reductions in systolic blood pressure compared to control
groups. Furthermore, substantial evidence supports alpha-tocopherol's ability to increase HDL-cholesterol levels and
decrease LDL-cholesterol concentrations, suggesting beneficial impacts on lipid profiles. The review also discusses alphatocopherol's
influence on additional cardiovascular biomarkers such as Troponin I, B-type Natriuretic Peptide (BNP), Nterminal
pro-BNP, Troponin T, C-reactive Protein (CRP), Lipoproteins, Creatine Kinase-MB (CK-MB), Myoglobin, and
Fibrinogen, highlighting its potential broader effects on cardiovascular health indicators. Overall, this review underscores
alpha-tocopherol's potential as an adjunctive therapy for managing cardiovascular risk factors, particularly hypertension
and dyslipidemia. The findings suggest that alpha-tocopherol supplementation may induce favourable changes in
cardiovascular biomarkers, offering insights into its therapeutic potential and calling for further investigation in clinical
settings.
Exploring the Phytoconstituents from Capparis zeylanica L. Stem Extract: Phytochemical Analysis, Molecular Docking, and Anticancer Activity.
Authors: Jain Bhavana . , Burade Kishore .
Published: October 2024

Ceylon caper (Capparis zeylanica Linn.), a climbing shrub found throughout the Indian subcontinent, has been utilized in traditional medicine in the direction of treating numerous ailments. The purpose of this study was to extract phytochemicals from C. zeylanica L.stems, evaluate the phytoconstituents and study the anticancer activity of the extract. Shade dried stems were collected, sieved and subjected to solvent extraction. Following standard phytochemical screening, We performed molecular docking studies to identify the most relevant pharmacological activities. In-vitro anticancer activity of ethanolic extract of C. zeylanica L. Stem was evaluated utilizing standard assay techniques. It indicates an interaction between extraction and EGFR kinases. And it found good IC50 values in enviro-enzymatic assay and inhibits phosphorylation of EGFR and its downstream signaling pathways in western blot assay.
A Sustainable Chromatographic Method for Simultaneous Analysis of Fluoxetine and Olanzapine Antidepressants: Assessment of Greenness with Green Metric Tools .
Authors: R Tiwari A , R Ambadekar S , A Bagul V A V , P Tamhanekar J
Published: October 2024

The combination of Fluoxetine HCL and Olanzapine treats depression in bipolar disorder and patients unresponsive to other antidepressants. The research aims to optimize a sensitive, simple, rapid, reliable, eco-friendly liquid chromatographic method by minimizing feedstock’s, reagents, energy, and waste to protect the environment and conserve resources, additionally assessed the environmental impact of a method using various green metric tools, and applied the method to pharmaceuticals. The separation was conducted using isocratic RP-HPLC with a DAD at 227nm. The mobile phase used was a 40:40:20 (v/v/v) ratios of buffer, acetonitrile, and ethanol. An L1 column (150 x 4.6mm, 5µm) was utilized with a flow rate of 1.5mL/min and injection volume of 5µL. The column oven and auto-sampler were both maintained at 45°C and 25°C respectively. The optimized method was validated as per ICH guidelines and found to be specific, precise, and robust to slight changes in mobile phase flow, column temperature, and buffer pH. Linearity was demonstrated from 0.1-150µg/mL for olanzapine and 0.4-610µg/mL for fluoxetine HCL. The accuracy was tested with recovery ranges of 0.1–157 µg/mL for olanzapine and 0.4–606 µg/mL for fluoxetine HCl in tablet placebo, and 0.1–150 µg/mL for olanzapine and 0.4–605 µg/mL for fluoxetine HCl in capsule placebo, indicating that the method is suitable for both tablet and capsule dosage forms. The method’s greenness was evaluated using AES, NEMI, GAPI, and AGREE tools. The optimized method was successfully applied to pharmaceutical analysis. The newly optimized method found simple, sensitive, rapid, eco-friendly, incorporating green analytical concepts, has been successfully achieved for the identification and quantification of Fluoxetine HCL and Olanzapine present in pharmaceuticals.
Development and Evaluation of Voriconazole Loaded Invasomes Gel for Enhanced Antifungal Activity.
Authors: S Amareshwar . , Sailaja Abbaraju Krishna
Published: October 2024

Although it has limited solubility and poor permeability to the skin, voriconazole (VRC) is a viable choice for the topical treatment of fungal infections. Owing to these constraints, treating the inflection requires several injections over an extended period. The goal of this work was to produce a VRC invasome gel with improved topical antifungal activity. The Box-Behnken design (BBD) program was utilized to optimize the IVS after it was created using the thin-film hydration process. The optimized invasome formulation through BBD has 159.9 nm of vesicle size, 68.58% of entrapment efficiency, and 23.5 mV of zeta potential. The spherical shape of the vesicle was revealed using scanning microscopy. According to FTIR spectra, the medication and polymers do not interact. The optimized invasomal VRC gel exhibited an optimum of 345 to 589 cp. Ex-vivo permeation studies of IG4 exhibited a higher flux of 0.168 as compared to pure voriconazole. An antimicrobial study was accepted to check the antimicrobial efficiency of voriconazole gel (IG4). The study confirmed a good zone of inhibition of the fungus infection (C. albicans). The voriconazole invasome’s potential diffusion and antibacterial efficacy are demonstrated here. Invasomal gel was found to be an effective carrier and a desirable strategy for improving the topical distribution of VRC to treat fungal infections.
Tofacitinib Citrate-Loaded Topical Gel for the Treatment of Rheumatoid Arthritis: Formulation and In-vitro-In-vivo Characterization.
Authors: Deepika V . , Naik S Srinu
Published: October 2024

This study aims to create and assess the anti-arthritic activity of tofacitinib citrate (TC) as a topical gel formulation. Using the gelling agent Carbopol 980 P, seven gel formulations were formed. The gel formulations were assessed for pH, drug content, spreadability, homogeneity, and in-vitro diffusion profile. Out of all the formulations, G7 exhibited superior release characteristics (99.1%) in comparison to the other formulations. The DSC research revealed a strong endothermal peak at 214.17°C and demonstrated an interaction with the excipients taken into consideration in this investigation. While carrying out the in-vivo study, formulation G7 successfully reduced inflammation induced by CFA. Ultimately, the optimal formulation for the “G7” can be determined & successfully treats inflammation associated with arthritis. As per stability studies, it was specified that there are no such major changes in the long-term and accelerated stability testing study.
Stability Indicating RP-HPLC Method Development and Validation for Quantification of Favipiravir and its Related Substances.
Authors: Bandaru Nagaraju . , Devi Jajula Naga Venkata Indira , Dudhe Prashik B. , Gambire Makarand Suresh , Labhala Swathi . , Bonthu Mohan Gandhi , Gayathri Alluri Pavani , Tata Prasanna Kumari
Published: October 2024

Background: Favipiravir is an influenza antiviral medication. DEM Avigan is the commercial name for a pyrazine carboxamide derivative. Aim: According to the guidelines framed by ICH - International Council for Harmonisation, the present method was developed and validated for the system suitability, specificity, linearity, precision, limit of quantification and limit of detection, accuracy, & robustness. Results: All the results obtained were within the acceptable range. This method was used to better separate the peaks of Favipiravir and its three impurities. The retention times and squared correlation coefficient values of Impurity-1, Impurity-2, Favipiravir & Impurity-3 were obtained at 1.998, 3.223, 4.438 & 7.052 min and 0.9993, 0.9995, 0.9998 & 0.9997 respectively. Conclusion: Thus, the results show that the suggested RP-HPLC method for separating three contaminants with Favipiravir was effective and may be utilised in routine pharmaceutical analysis and quality control. Forced degradation was carried out under different stress conditions thus proving as stability indicating as per ICH guidelines.
HPMC Extended-Release Multi-Composite Matrix for Co-delivery of Oxcarbamazepine and Vitamin D.
Authors: Amer Sarah K , Alaa Walaa . , Eshra AG .
Published: October 2024

Background: Carbamazepine (CBZ) is considered as first-line treatment for epilepsy. The literature has signified a history of non-uniform drug performance and clinical failures. However, many studies suggested that Oxcarbazepine (OXC), a structural analog of CBZ, may have an equivalent antiepileptic effect. OXC follows a different metabolic pathway other than CBZ. However, both share the same mechanism of action by blocking voltage-gated sodium channels. Objectives: This study aimed to form hydroxypropyl methylcellulose (HPMC) extended-release tablets containing OXC combined with vitamin D. Methods: These formulated tablets were tested for their dissolution rate, tablet hardness, friability, thickness and pharmacokinetic parameters (Cmax and Cmin). Blood sodium levels were additionally investigated to ensure the absence of hyponatremia; the main side effect of long-term use of CBZ and some of its derivatives. Results: The use of HPMC inhibited the formation of dihydrate OXC form thus offering a significant extended-release profile. OXC also showed a highlighted capability to attain high bioavailability. Microcrystalline cellulose (MCC) was also added to tablets formed to inhibit polymorphic transformation. Tablets containing OXC co-delivered with vitamin D ensured significantly decreased susceptibility to hyponatremia, and an extended-release profile was evident. Lower amounts of OXC were loaded in formed tablets containing vitamin D owing to the synergistic effect between vitamin D and antiepileptic drugs. Conclusion: Conclusively, employing these newly HPMC-constructed tablets of OXC co-delivered with vitamin D appeared to be a promising option for the effective management of epilepsy with least side effects.
Release Kinetic of Sustained Release Matrix Tablet of Linezolid Containing Polymer Blend.
Authors: Ujjwal Kukreti . , Nidhi Nainwal . , Yogita Ale . , Teena Negi . , Saurav Pandey . , Vikash Jakhmola . , Tarun Parashar . , Anjali Bhatt . , Arti Kori .
Published: October 2024

Tuberculosis (TB) is a bacterial infection mainly affecting the lungs. TB is a major health problem worldwide and the occurrence of extensively drug-resistant TB (XDR-TB) and multidrug-resistant TB (MDR-TB) offers considerable hurdles to effective treatment and disease management. The growth of treatment-resistant Mycobacterium TB strains has prompted the investigation of alternate therapeutic techniques, including the application of sustained drug delivery. Sustained-release drugs reduce the need for frequent dosing can extend the effects of linezolid by 8 to 12 hours, thus improving the patient’s adherence to the treatment. The objective of this study is to formulate oral sustained-release linezolid tablets employing blends of polymers like hydroxy propyl methyl cellulose (HPMC)- K100M, ethyl cellulose, xanthan gum, and chitosan to provide sustained drug release. Linezolid was made into a sustained-release tablet by employing the direct compression method using different drug-polymer ratios. Formulated tablets were compared with marketed formulations to assess the similarity factor. The formulation was assessed for drug-excipient interaction, solubility, flow properties, etc. The diameter, friability, thickness, hardness, weight variation, in-vitro drug release, and drug release kinetics of compressed tablets were examined. Drug release research proved that all polymers were able to sustain drug release. Formulation (F5) with HPMC (100mg) and ethyl cellulose (100mg) resulted in 49.89% drug release after 8 hours, making it the optimal formulation. According to the kinetic model of the drug release, the Higuchi model was selected, which indicates the diffusion of the drug from an insoluble matrix. The optimized formulation showed a similarity factor of 52% with the marketed formulation, suggesting similarity in drug release between these two formulations.