bluuebunny/crossref_metadata_2025 huggingface dataset:
The Molecular Diversity Scope of Oxindole Derivatives in Organic Synthesis
Authors: Ziarani Ghodsi Mohammadi , Javadi Fatemeh , Mohajer Fatemeh
Published: January 2021

The role of oxindole derivatives is discussed as starting materials in diverse organic
reactions, including two and more components, between the years 2014 until 2020. Oxindoles
are famous because of their biological properties. For instance, chromanone-fused
polycyclic pyrrolidinyl-dispirooxindoles, functionalized polycyclic spiro-fused carbocyclicoxindole,
and 3,3-disubstituted oxindoles have anti-cancer, anti-tumor, and anti-microbial
properties, respectively. Therefore, various methods for synthesizing the oxindole structures
have received much attention in organic chemistry.
Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms
Authors: Chen Xing-Dong , Tang Jun-Jie , Feng Shuang , Huang Hua , Lu Feng-Nian , Lu Xiu-Min , Wang Yong-Tang
Published: January 2021

Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honeysuckle
and eucommia, and has a wide range of biological activities, and pharmacological effects.
Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled
with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like
symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptotic
effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of
its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treatment
of PTSD and its comorbidities.
Transcriptional and Non-transcriptional Regulation of Glucose Metabolism and Insulin Sensitivity through Vitamin D
Authors: Khorami Somayeh A.H. , Khaza’ai Huzwah
Published: January 2021

Enormous progress in the investigation of vitamin D is currently being made from the
perspective of basic science to clinical medicine. The typical view of vitamin D function limited to
calcium metabolism and bone homeostasis has undergone extensive revision and it has been revealed
that vitamin D receptors exist in most tissues of the body. Nowadays, one of the most popular
aspects of vitamin D in research area is its role in glucose metabolism and insulin resistance.
The functional mechanism of vitamin D in metabolism includes genomic and rapid non-genomic
actions that are discussed in this review. Briefly, the modulatory action of vitamin D in the gene expression
of insulin signaling compartments and secretion of insulin hormone may point to its role
in the pathogenesis and development of type II diabetes. Vitamin D induced activation of the
PI3K/AKT pathway is through PTEN-mediated AKT downregulation. Also, allelic variations in
VDR and DBP might affect insulin secretion and diabetes occurrence. Vitamin D influences insulin
secretion from β-cell through calcium-dependent endopeptidases, which promotes the conversion
of pro-insulin to insulin; hence it can be declared that calcium and vitamin D are essential for
insulin exocytosis. Hypovitaminosis D in obese individuals is also associated with higher levels of
serum parathormone, through which this secondary hyperparathyroidism probably contributes to insulin
resistance associated with obesity. Moreover, vitamin D is an immune modulator that may affect
inflammation as a contributor to diabetes.
Pharmacokinetic Interaction between Asari Radix et Rhizoma and Dried Ginger (Zingiber officinalis) in Rats
Authors: Zhuang Xingxing , Zhou Li , Miao Renhua , Ni Shoudong , Li Meng
Published: January 2021

Introduction:

Asari Radix et Rhizoma (ARR) and dried ginger (Zingiber officinalis)
(DG) are often used together in drug preparations in traditional Chinese medicine (TCM) to treat
respiratory diseases, including cold, bronchitis and pneumonia. Previous studies suggested that
ARR and/or DG may influence the pharmacokinetics of other herbal components. In the current
study, we examined pharmacokinetic interactions between ARR and DG in rats after oral administration.

Methods:

We developed a method based on ultra-high-performance liquid chromatographytandem
mass spectrometry to simultaneously measure serum concentrations of two active components
each in ARR (L-asarinin and sesamin) and DG (6-gingerol and 6-shogaol). Adult Sprague-
Dawley rats were starved overnight, then given ARR extract, DO extract, or a co-decoction
of ARR and DG by gastric gavage (6 g raw material per kg body weight; n = 6 per group). Blood
samples were collected prior to drug administration and at the following times (h) afterward: 0.5,
1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 12.0 and 24.0. Pharmacokinetic parameters were compared using
Student’s t test for independent samples.

Results:

A simple, rapid, sensitive analytical method has been developed to detect four bioactive
components simultaneously in the ARR-DG herbal pair. Pharmacokinetic parameters including
Cmax, Tmax, T1/2 and AUC(0~t) were calculated using the non-compartmental model with the DAS
2.0 pharmacokinetic software. For L-asarinin, Tmax was 2.00 ± 0.00 h in ARR animals and
1.67±0.26 h in ARR-DG animals (P<0.05), T1/2 was 8.58 ± 1.75 h in ARR and 11.93 ± 2.13 h in
ARR-DG (P<0.05). For 6-gingerol, Cmax was 350.48 ± 23.85 ng/mL in DG animals and 300.21 ±
20.02 ng/mL in ARR-DG (P<0.01), Tmax was 2.83 ± 0.41 h in DG and 2.17 ± 0.41 h in ARR-DG
(P<0.05) and AUC(0~t) was 1.93 ± 0.15 mg/mL.h in ARR and 1.70 ± 0.15 mg/mL.h in ARR-DG
(P<0.05). For 6-shogaol, Cmax was 390.28 ± 26.02 ng/mL in DG animals and 455.63 ± 31.01
ng/mL in ARR-DG (P<0.01), Tmax was 2.93 ± 0.10 h in DG and 1.92 ± 0.10 h in ARR-DG
(P<0.01), T1/2 was 3.74 ± 0.29 h in DG and 3.28 ± 0.22 h in ARR-DG (P<0.01), and AUC(0~t)
was 2.15 ± 0.18 mg/mL.h in DG and 2.73 ± 0.15 mg/mL.h in ARR-DG (P<0.01).

Conclusions:

Pharmacokinetic interactions between ARR and DG decreased Tmax, increased T1/2
but did not affect the overall bioavailability of L-asarinin in ARR. The interactions in ARR-DG
decreased Cmax and Tmax but increased T1/2 and AUC(0~t) of 6-gingerol in DG. The interactions increased
Cmax and AUC(0~t) but decreased Tmax and T1/2 of 6-shogaol in DG. Interactions in ARRDG
did not affect the pharmacokinetics of sesamin.
Salvia miltiorrhiza in Anti-diabetic Angiopathy
Authors: Yin Zequn , Wang Xuerui , Yang Xiaoxiao , Chen Yuanli , Duan Yajun , Han Jihong
Published: January 2021

Background::

Salvia miltiorrhiza, a traditional Chinese medicine, also named as Danshen in China, is widely used for treatment of cardiovascular disease. It demonstrates multiple biological functions, such as anti-oxidative stress, anti-inflammation and anti-thrombosis. Diabetic angiopathy is one of the diabetic complications with macro- and microangiopathy. The macroangiopathy mainly occurs to arteries, while the microangiopathy mainly includes diabetic retinopathy and nephropathy. Many factors associated with diabetes, such as metabolic abnormalities and oxidative stress, can induce vascular lesions. These factors promote the accumulation of lipids as well as inflammatory cytokines, increase production of extracellular cell matrix, and impair endothelium functions, thereby leading to vascular dysfunction.

Conclusion::

This review attempts to summarize the progress of the studies of Salvia miltiorrhiza on diabetic angiopathy, including improving endothelial function, anti-oxidative stress, reducing the risk of vascular blockage, inhibiting inflammation as well as regulating lipid metabolism. We also summarize the pharmacological activity of bioactive components in Salvia miltiorrhiza and the delivery systems. We made the conclusion that Salvia miltiorrhiza can be used as a potential auxiliary drug for treatment of diabetic angiopathy.
Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119.
Authors: Randhawa Parmissa , Olson Aeli P. , Chen Shaohuang , Gower-Fry Kaley Lexi , Hoehr Cornelia , Engle Jonathan W. , Ramogida Caterina F. , Radchenko Valery
Published: January 2021

Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have
the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to
fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate
delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation
and applications of two promising candidates for Targeted Auger Therapy, namely antimony-
119 (119Sb) and mercury-197 (197Hg). Both radionuclides have great potential to become efficient
tools for TRT. We also highlight our current progress on the production of both radionuclides
at TRIUMF and the University of Wisconsin.
Proactive Routing Mechanism for Removing Far Sensor in IoT using A
Design of B * Index
Authors: Perumalsamy Deepalakshmi , Sundararajan Geetha
Published: January 2021

Background::

The concern with the IoT node is energy since nodes are depleted as their energy
utilization is incrementally reduced with the reduction in far off nodes. The nodes will consume
energy when it senses the data, followed with the Computation, and further for transmission.

Method::

We proposed the phases for Energy-saving at nodes by Enhanced Agglomerative Clustering,
Dynamic Selection of Leader, disposal of faraway sensor, and B * tree cloud storage and retrieval. In a
typical IoT system, the nodes are deployed in the environment initially. Nodes are clustered using Enhanced
Agglomerative Clustering Algorithm. A far node elimination will be implemented for the nodes
not in the cluster region.

Results::

By eliminating the need of far-off sensors, we can reduce the energy used. This in turn can also
improve the life of sensors. When appropriate, sensitive data are moved from IoT devices and stored in
the cloud.

Conclusion::

This paper also proposes an approach to fetch the data from IoT by using the Query Predicate
method. This research work proposes a unique choice of grouping by estimating the parameters as
energy, separation, thickness and portability.
Nickel-copper Co-catalyzed Sustainable Synthesis of Diaryl-chalcogenides
Authors: Kundu Debasish , Roy Anup , Singha Abhijit , Panja Subir
Published: January 2021

In recent times, Nickel has become a powerful alternative transition metal catalyst for performing
cross-coupling reactions due to its low cost and better sustainability. Thus, a sustainable Nicatalyzed
C-Se cross coupling has been developed in the presence of catalytic amount of copper iodide
as co-catalyst. A wide range of substituted diaryl selenides has been synthesized by this Ni-Cu dual
catalyzed C-Se cross coupling. The reaction is following an oxidative addition and reductive elimination
pathway where Cu is playing an important role in transmetalation. The mechanism of the reaction
was established by several experimental techniques.
Nanotechnology Mediated Diagnosis of Type II Diabetes Mellitus
Authors: Rajora Anjali , Nagpal Kalpana
Published: January 2021

Metabolic diseases are the consequences of abnormal chemical reactions in
the body leading to variation in the normal metabolic processes. These diseases have actually
reached an epidemic stage around the globe. Among the several types of metabolic
disorders, type II diabetes is quite serious and dependent on glucose levels in the
blood. The major challenge is the continuous monitoring of blood glucose levels.
Among the different blood sugar level diagnostic strategies, nanotechnology may offer
several advantages over traditional systems owing to the better surface area of sensors,
the improved catalytic property of electrodes, plus better handling. For this reason, different
types of nanosensors (to measure blood glucose level) and nanomaterials (to improve
glucose sensor function) have been investigated by various researchers. This work
is an effort to discuss the role of nanosensors and the major advancements that have
been utilized so far for the effective and reproducible diagnosis of blood glucose level,
which may provide a better and effective diagnosis for type 2 diabetes.
TOP COYS (AUTOMATED PLANT CONTROLLING SYSTEMS): SOLUSI PENGENDALIAN LINGKUNGAN PADA BUDIDAYA BUNGA KRISAN DI ASOSIASI TANI “ASTHA BUNDA” KALIURANG
Authors: Erdyanto Haris
Published: January 2021

Tujuan penerapan alat ini antara lain untuk mengetahui desain TOP COYS (Automated Plant Controlling Systems), mengetahui cara kerja TOP COYS dan mengetahui produktivitas petani krisan setelah menggunakan teknologi TOP COYS. Penelitian ini dilaksanakan di asosiasi petani bunga krisan ASTHA BUNDA yang terletak di Jalan Kaliurang Km. 21 Desa Pakembinangun, Kecamatan Pakem, Sleman. Pelaksanaan program dilakukan selama 5 bulan yaitu bulan Maret sampai Mei 2017. Metode dalam program ini yaitu melakukan perancangan awal yang disesuaikan dengan lahan, menyempurnakan alat, melakukan uji alat yang telah disempurnakan, melakukan implementasi alat dan melakukan monitoring serta evaluasi terhadap kinerja alat untuk meningkatkan produktifitas bunga krisan. Luaran yang diharapkan dari penelitian ini yaitu terciptanya TOP COYS sesuai dengan kondisi lahan mitra sebagai produk utama dari penelitian ini, TOP COYS mampu meningkatkan produktifitas dan kualitas tanaman bunga krisan, Kata Kunci : TOP COYS, Bunga Krisan, Produktifitas
TRAINER SISTEM KENDALI ELEKTRONIK UNTUK PEMBELAJARAN MENGOPERASIKAN SISTEM KENDALI ELEKTRONIK
Authors: Eliza Fivia
Published: January 2021

Dalam pembelajaran Mengoperasikan Sistem Kendali Elektronik  (MSKE) yang dilaksanakan di SMK N 2 Lubuk Basung perlu dirancang dan dibuat media pembelajaran trainer yang dapat dimanfaatkan oleh guru dan siswa, baik secara individu maupun secara bersama-sama di dalam kelas. Dengan adanya media ini, siswa tidak hanya mendapatkan penjelasan, melainkan juga bisa belajar mandiri secara bergantian. Trainer ini dirancang dengan tujuan memberikan kemudahan dalam proses pembelajaran, dan mengikuti perkembangan Ilmu Pengetahuan dan Teknologi terutama di bidang pendidikan di SMK Negeri 2 Lubuk Basung. Perancangan trainer ini disusun sedemikian rupa berdasarkan silabus dan materi pada mata pelajaran MSKE. Trainer ini dapat membantu guru dalam menyampaikan materi di depan kelas, guru memfasilitasi dan mengatur jalannya proses pembelajaran. Siswa akan mengikuti proses pembelajaran secara aktif, dan tetap berinteraksi baik dengan guru, dengan media maupun dengan sesama siswa. Kata Kunci : Trainer, Electronis control system
PENGATUR POTENSIO GANDA BERJANGKAH UNTUK MODUL PEMBELAJARAN PENGOPERASIAN MOTOR AC TIGA FASA
Authors: Ramadani Wulan
Published: January 2021

Penelitian ini dilakukan untuk dapat mengatur tegangan dan frekuensi sumber tegangan tiga fasa dengan rentang 0 – 13 V untuk mencatu motor motor tiga fasa dalam praktik elektronika daya. Penggunaan tegangan rendah bertujuan mengamankan alat ukur maupun praktikan dari kemungkinan terjadi kesalahan yang membahayakan. Metode yang dilakukan dengan menempuh tahapan, yakni perancangan, analisa kebutuhan, identifikasi alat dan bahan, pembuatan perangkat keras dan perangkat lunak serta pengujian alat. Sistem yang dirancang terdiri dari empat bagian: (1) catu daya, (2) sistem minimum, (3) untai driver motor, (4) program. Berdasarkan hasil pengujian diperoleh rentang tegangan 0 - 13 volt, dan frekuensi 0 - 31,25 Hz dalam empat posisi yakni stop, kecepatan rendah, kecepatan sedang dan kecepatan tinggi. Sinyal pengatur tegangan dan frekuensi diperoleh dengan mengubah nilai resistor pada dua buah osilator HEF4047 yang mengendalikan IC PWM 3 fasa HEF4752VP untuk menghasilkan efek perubahan tegangan dan frekuensi secara serentak. Kata kunci: Mikrokontroler, Motor Tiga Fasa, Pengatur Kecepatan.
INTELEGENT STICK FOR BLIND (INSTISBLIND) INOVASI ALAT BANTU MOBILITAS PENCEGAHAN KEBISINGAN HUJAN UNTUK MENINGKATKAN KEMANDIRIAN PENYANDANG TUNANETRA
Authors: Milati Nur
Published: January 2021

Pentingnya keterampilan penggunaan tongkat bagi tunanetra untuk aktivitas berpindah tempat. Selain itu hilangnya fungsi visual menuntut adanya latihan untuk mengembangkan indra-indra lain, terutama indra pendengaran. Suara dapat memberikan informasi tentang lokasi, penyebab, atau sumber suatu objek(strickling, 2010:1). Namun dari berbagai inovasi tersebut terdapat satu kondisi yang sangat dibutuhkan kegunaannya oleh tunanetra yang belum dilirik oleh banyak inovator yaitu berupa tongkat tunanetra yang tetap bisa digunakan ketika hujan. Inovator membuat inovasi Intelegent Stick For Blind (Instisblind) Inovasi Alat Bantu Mobilitas Pencegahan Kebisingan Hujan Untuk Meningkatkan Kemandirian Penyandang Tunanetra. Inovasi menggunakan metode Linear Sequential Model (LSM) yang terdiri dari 4 tahapan  yaitu tahap analisis dan studi literatur, desain/perancangan sistem, perakitan sistem elektronik (assembly-electrnics systems), dan pengujian. Tujuan dari inovasi ini adalah untuk mengetahui rancangan, sistem kerja, dan keunggulan serta manfaat Instisblind bagi tunanetra. Tahap uji coba fungsional peneliti menguji cara kerja disetiap komponen. Sensor proximity mendeteksi objek rintangan  jarak +-30 cm. Peneliti melakukan validasi kepada ahli media, memperoleh hasil 81.2 % dengan kategori layak. Kemudian uji coba dilakukan SLB A Yaketunis  memperoleh respon  baik dari pengguna atau  tunanetra. Pada uji coba kepada pengguna ini dilakukan pengambilan data terhadap kebermanfaatan alat dan mendapat hasil 87.9 % dengan kategori sangat bermanfaat dan layak digunakan.
“Smart Turtle Egg Incubator” (STUR EGI) Bertenaga Surya untuk Meningkatkan Keberhasilan Penetasan Telur Penyu
Authors: Wibawa Wisnu Alfianta
Published: January 2021

Penyu merupakan salah satu hewan yang sangat langka dan dilindungi.  Menurut artikel yang ditulis oleh Wilujeng Kharisma dalam pikiran-rakyat.com, jumlah populasi penyu saat ini terus menurun tiap tahunnya. Tercatat oleh WWF sejak tahun 2012 – 2017 populasi penyu keseluruhan hanya sekitar 1.385 hingga 2.062 ekor. Kondisi iklim yang meningkat diatas 29 derajat celcius menyebabkan sebagian besar tukik yang menetas berkelamin betina sehingga penyu betina susah untuk mencari pasangannya. Penciptaan inovasi “Smart Turtle Egg Incubator” (STUR EGI) bertujuan untuk meningkatkan keberhasilan penetasan telur penyu dan menyeimbangkan ekosistem penyu yang hampir punah. Metode yang kami gunakan untuk melaksanakan PKM ini adalah menggunakan metode perancangan, proses pelaksanaan dan evaluasi. Cara kerja alat ini menggunakan Arduino Mega sebagai mikrokontroler serta Solar Cell sebagai penyuplai daya. Sensor suhu dan kelembaban digunakan sebagai input yang mengirim data untuk menyetel peltier, kipas, dan pompa air untuk menjaga suhu dan kelembaban. Selain dapat menjaga suhu dan kelembaban secara otomatis alat ini juga dapat mengatur jenis kelamin dari telur yang ditetaskan.
IMPLEMENTASI KONSEP PEMROGRAMAN BERORIENTASI OBJEK PADA APLIKASI SISTEM PARKIR MENGGUNAKAN BAHASA PEMROGRAMAN JAVA
Authors: Ilham Nadifah Adya
Published: January 2021

Perkembangan Teknologi Informasi sudah semakin pesat. Banyak instansi atau perusahaan yang telah menggunakan sistem informasi untuk proses operasional yang secara manual menjadi sistem yang terotomatis dan terintegrasi antara sistem yang satu dan sistem yang lainnya satu diantaranya ialah sistem parkir. Di Indonesia masih banyak tempat penitipan kendaraan yang menggunakan sistem parkir secara manual, hal ini membuat ketidaktahuan petugas parkir dengan harga tarif yang telah ditetapkan serta lamanya waktu terparkir kendaraan tersebut dan menyulitkan dalam proses laporan perhitungan kendaraan yang terparkir. Untuk itu diperlukan sebuah sistem parkir yang terintegrasi sehingga dapat diterapkan pada tempat penitipan kendaraan yang masih manual. Maka dalam pembuatan sistem parkir tersebut menggunakan konsep pemrograman. Konsep program yang akan digunakan ini adalah konsep Pemrograman Berorientasi Objek dengan bahasa pemrograman Java dan editor menggunakan Netbeans 8.2 untuk menjalankan programnya. Metode dalam menjalankan penelitian ini yaitu menggunanakan 2 metode, yakni metode untuk pengumpulan data dengan metode deskripsi dan metode untuk pengembangan sistem dengan waterfall. Dengan adanya sistem parkir yang berbasik aplikasi desktop ini akan memberikan kenyamanan bagi pengguna parkir dan juga mengefisiensikan kinerja petugas parkir. Sehingga diharapkan adanya  kecepatan, dan keakuratan dalam pendataan parkir kendaraan pada suatu tempat penitipan kendaraan di Indonesia.Kata kunci: Parkir, Pemrograman Berorientasi Objek, Java
STUDI POWER QUALITY DI BALAI LATIHAN PENDIDIKAN TEKNIK (BLPT) YOGYAKARTA
Authors: Wardhana Alex Sandria Jaya
Published: January 2021

The quality of electrical power is a common condition that describes the characteristics of the parameters of electrical quantities. This study aims to determine the power quality profile that includes current, voltage, active power , reactive power , apparent power, frequency , harmonic current and voltage harmonics. Power quality profile is done by measuring for 24 hours to determine the characteristic qualities of the object of research in Balai Latihan Pendidikan Teknik (BLPT) Yogyakarta. Measurements were taken at each of output transformer 250 kVA at BLPT Yogyakarta . Based on the measurement results , the total peak load for loading in BLPT Yogyakarta is 129.242,45 VA or equal to 51.70% of the installed transformer capacity. The most prominent conditions of measurement results are any indication of the current flow in the neutral wire is high enough, ie 103,05 amperes, which will impact on the value of the energy loss in the neutral wire and losses in the transformer.
STEM-integrated encyclopaedia as the enrichment for elementary school students
Authors: Erviana Vera Yuli , Asmara Anjar Purba
Published: January 2021

The objective of the study is to describe the effectiveness and the fitness of the STEM-Integrated encyclopaedia as the enrichment for the learning materials of Temperature and Heat among Grade V Students in the elementary school degree. Concerning the objective of the study, the nature of the study is Research and Development (R&D). In conducting the R&D, the ADDIE (Analysis, Design, Development, Implementation and Evaluation) model had been adopted. In overall, the Analysis was directed toward the problems that had occurred among the students, the Design was related to the media that should be presented to the students, the Development referred to the model of the media that had been in accordance to the needs of the students, the Implemented was related to the Development that had been performed and the Evaluation was directed toward the media that had been developed. In gathering the data, several techniques had been applied namely interview, test administration and questionnaire distribution. Then, in analysing the data both of the qualitative and the quantitative approach had been adopted. Furthermore, in testing the hypothesis, the paired t-test had been administrated to identify the results of the effectiveness of the study. Based on the results of the assessment by the media validator, the material validator and the learning validator, it might be concluded that the STEM-integrated encyclopaedia has been fit for the implementation of the learning process among the Grade V students within the elementary school degree. In the same time, the results of the test show that the effectiveness of the STEM-integrated encyclopaedia has been significant since in the conduct of the hypothesis test (t-test) using the paired t-test it is found that the t-count (10.325) > the t-table (2.048). Besides, it is also found that the significance (p-value) has been 0.000, which is lower than the α 5.00% (0.0000 < 0.050) from the results of the comparison between the pre-test and the post-test. Therefore, the use of the STEM-integrated encyclopaedia has been fit for implementation in the elementary school degree.
The problem-based learning e-module of planes using Kvisoft Flipbook Maker for elementary school students
Authors: Triwahyuningtyas Dyah , Ningtyas Ayu Setyo , Rahayu Sri
Published: January 2021

The conduct of the present study is encouraged by the needs to afford the teaching materials in the form of an electronic learning module or e-module that can be combined with the problem-based learning approach in order to expand the students’ insights in and draw the students’ interest toward Mathematics. These needs should be afforded because the present teaching materials used in the learning process are still conventional and, consequently, the students become easily bored. Departing from this elaboration, the objective of the present study is to develop the teaching materials, especially in the subject “Simple Planes” in the Third Grade, and to measure the validity, the practicality, and the effectiveness of the media that have been developed. In conducting the study, the ADDIE model, standing for Analysis, Design, Development, Implementation, and Evaluation, had been adopted and the data were gathered by means of validation sheet and response questionnaire. After the data had been gathered, the data were analysed by using the qualitative and the quantitative data analysis technique. The results of the study show that the problem-based learning (PBL)-based planes e-module using the KVISFOT Flipbook Maker that has been developed is already valid with the mean score of 85.82%. At the same time, the results of the response category show that the problem-based learning (PBL)-based planes e-module using the KVISFOT Flipbook Maker that has been developed is already good with the mean score 3.78. Furthermore, the mean score from the effectiveness test using the evaluation test for the Third-Grade students is 90.47. Therefore, it can be concluded that the e-module is able to improve the students’ learning motivation so that the learning process can proceed fluently.
Can children's religiosity be built through family's religious culture and the discipline in attending TPA at school?
Authors: Prehadini Tampi , Senen Anwar , Mustadi Ali
Published: January 2021

This study aims to find out the effects of family’s religious culture and the discipline in attending ‘Taman Pendidikan Al Qur’an (TPA) at school on the first grade students’ religiosity. This study used the ex-post facto quantitative approach, while the population was all first grade student in Pengasih District, Kulon Progo regency with a total of 585 students, then 238 of them were taken randomly as the sample. The technique for collecting data was using three questionnaires, such as students’ religiosity, family’s religious culture, and the discipline in attending TPA at school questionnaire. The research instrument was tested to 120 students. The validity test of the instrument used was the content validity with expert judgement technique, whereas the difference power index tested by product moment correlation formula. Instruments’ reliability was using Cronbach’s Alpha formula. The analysis of prerequisite test that had been used are the normality, linearity, and multi-collinearity test. Data analysis that used was multiple regression. The result shows that: 1) family’s religious culture partially gives significant effect on first grade students’ religiosity; 2) the discipline in attending TPA at school partially doesn’t give significant effect on first grade students’ religiosity; and 3) family’s religious culture and the discipline in attending TPA at school simultaneously give significant effect on first grade students’ religiosity with the effect is 5.2%.
HOTS study primary teacher education UNNES students based on self-regulated learning
Authors: Nugraheni Nursiwi , Waluya St. Budi , Walid Walid
Published: January 2021

This research aims to study students’ High Order Thinking Skills (HOTS) in Primary Teacher Education Department of Universitas Negeri Semarang (UNNES) viewed from their Self-Regulated Learning (SRL). The research method in this research is a mixed method of a sequential explanatory model. This research was conducted in the Department of Primary Teacher Education at UNNES for students of class 2020 in the Basic Mathematical Concept course. Data collection techniques using questionnaires, documentation, interviews. Analysis of quantitative data in the form of validity and reliability of the instrument was followed by descriptive analysis. Qualitative data analysis was performed by triangulation and descriptive statistical analysis. Analysis of quantitative data found two categories of the level of SRL, namely medium and high levels. The results of the analysis of student answers were obtained: (1) Students with moderate SRL category interpret the questions into Mathematical language, and the way they identified the problem is less communicative, while the students with high SRL category interpret the questions into Mathematical language communicatively; (2) Based on students’ ability to evaluate, students with moderate SRL category have not been fluent yet, while the students with high SRL category have been fluent in evaluating, and (3) Based on their creativity, students with moderate SRL still need more practices, while students with high SRL category have been fluent. The conclusion of this study is the ability to interpret problems and the habit of examining problem-solving carried out into the differences between the two categories.
Ana, adolescente nota dez?
Authors: Carneiro Cristiana , Silva Raisa de Paula
Published: January 2021

O artigo tem como objetivo discutir entraves na escolarização a partir de um estudo de caso realizado com uma adolescente diagnosticada com Transtorno Opositivo Desafiador (TOD), Transtorno do Déficit de Atenção com Hiperatividade (TDAH) e dificuldade de aprendizagem.1 Para isto, buscamos aprofundar o tema das dificuldades de aprendizagem a fim de tecer uma reflexão sobre o diagnóstico de Ana no que se dirige ao aprender. Discutimos a diferença entre a preponderância do organismo em detrimento do corpo nas leituras sobre entraves no aprender e sua relação com a patologização. Termos como mal-estar, estilos cognitivos e de aprendizagem foram utilizados para ampliar o debate sobre as dificuldades em estar na escola e responder às suas demandas. Esta ampliação permitiu uma nova compreensão sobre o aprender e sua relação com a escola.
Trois occurrences d’amour pathologique parental?
Authors: Levy Robert
Published: January 2021

Devemos amar as crianças para educá-las e, a fortiori, para cuidar delas? Como pensar a prática da pedagogia e da terapia com as crianças de outro modo que não seja as amando? Algumas ocorrências da clínica psicanalítica vão lançar luz sobre essa questão, retomando o que Lacan e Winnicott podem teorizar sobre como pode haver ou não adaptação no que diz respeito à relação dos pais ou educadores com o amor que têm pelos filhos. Examinaremos o impacto que o desejo pode ter na fantasia infantil e seus efeitos na construção do sintoma. Vamos considerar como uma criança pode sair do lugar da fantasia, como ela pode viver de outro modo que não seja no excesso de amor, finalmente, como aceitar o “amoródio” de uma mãe. Tantas questões requerem desenvolvimento e tentaremos considerá-las por meio de nossa clínica.
Perspectivas interdisciplinares na educação a partir de Habermas, Freire e Santos
Authors: Hammes Lúcio Jorge , Zitkoski Jaime José , Hammes Itamar Luís
Published: January 2021

O artigo tem o objetivo de discutir os problemas centrais que a educação contemporânea enfrenta em relação aos processos formativos, tais como: o perfil dos egressos dos cursos em relação às necessidades e demandas da sociedade, a urgência de um conhecimento interdisciplinar e a responsabilidade ética e cidadã. A metodologia consiste num estudo bibliográfico, via hermenêutica de textos. Os conceitos centrais que servem de aporte teórico para este estudo compreendem as temáticas da Interdisciplinaridade, da Crise de paradigmas e as Alternativas para o futuro em sociedade. Habermas, Freire e Santos são os três autores que servem de horizonte na reflexão crítica sobre o tema e nos inspiram na busca dos fundamentos para uma educação do futuro. O desafio apontado é o de construir um novo modelo de formação cultural, que supere os problemas mais profundos do mundo atual, tais como: a alienação, a exclusão social, a banalização da violência e a crise ética da atualidade.
As relações entre a formação do PNAIC e as práticas de alfabetização
Authors: Braga Andreia , Feldkercher Nadiane
Published: January 2021

Alfabetizar envolve a apropriação das práticas de leitura e de escrita pelos aprendizes, o que determina tanto a formação quanto as práticas pedagógicas dos professores alfabetizadores. Neste trabalho objetivamos identificar e analisar quais aspectos da formação do Pacto Nacional Pela Alfabetização na Idade Certa (PNAIC) fazem parte das práticas alfabetizadoras das professoras após as etapas desta formação. A investigação teve uma abordagem qualitativa, com procedimentos de coleta de dados por meio de entrevistas com seis professoras alfabetizadoras. Os dados coletados foram trabalhados a partir da análise de conteúdo. Os resultados apontam que a formação do PNAIC trouxe contribuições para as práticas, incluindo o aprofundamento de teorias, a melhor compreensão da avaliação dos níveis de escrita dos alunos, a ampliação do uso da ludicidade, a importância do planejamento e o melhor entendimento da função social da leitura e da escrita. Evidenciamos que o PNAIC foi relevante para as professoras alfabetizadoras, sendo significativo para seus processos de formação docente e para a ressignificação de suas práticas.
Da escola, do escolar, da inclusão
Authors: Ferreira Carla Mercês , Vorcaro Angela
Published: January 2021

O presente artigo tem como principal objetivo discutir aspectos conceituais e estruturais da escola, do escolar e da inclusão. Sua construção está disposta em três seções. Na primeira, discute-se elementos da escola pelo viés estrutural, abordando as noções de forma e organização escolar e sua disseminação nas instituições educativas modernas. Em continuidade com a seção anterior, discorre-se sobre a noção/lugar do escolar atribuído às crianças na sua inserção na escola e as possíveis transformações advindas da condição de escolar, considerando a ruptura com formas anteriores de socialização para a infância. Na última seção, contempla-se a inclusão escolar enfatizando aspectos políticos como também mecanismos de resistências advindos na tentativa de fazer cumprir as determinações legais no cotidiano das escolas. Aborda-se manifestações por parte dos atores envolvidos com o processo de inclusão educacional considerando que processos de formação reativa ao trabalho educativo com crianças em situação de deficiência buscam se apoiar nas estruturas da forma e organização escolares
Мартенситные превращения и эффект памяти формы биосовместимых сплавов TiNiMoAl
Authors: Моногенов А.Н. , Гюнтер В.Э. , Марченко Е.С. , Аникеев С.Г. , Ходоренко В.Н. , Радкевич А.А. , Подгорный В.Ю. , Артюхова Н.В.
Published: January 2021

A study of martensitic transformations and characteristics of the shape memory effect of medical alloys (TH-10) alloyed with aluminum up to 4 at.% Al long the TiNiMo-TiMeMo section was carried out. Aluminum has a fairly smooth effect on the temperatures of the beginning and end of the direct and reverse martensitic transformation, as well as similar characteristics under load, which makes it possible to use alloying with aluminum as a method for controlling the temperature range of shape change with the shape memory effect.
Online State of Charge Prediction in Next Generation Vehicle Batteries Using Deep Recurrent Neural Networks and Continuous Model Size Control
Authors: Hespeler Steven , Fuqua Donovan ,   College of Business, New Mexico State University, Las Cruces, NM, USA
Published: January 2021

This investigation presents a data-driven Long-short Term Memory battery model for predicting State of Charge for lithium-ion batteries LiFePO4 for next-generation vehicle operations. Our modified algorithm builds and updates a model using multivariate inputs that include physical properties, voltage, current, and ambient temperature during operations. The primary research goal is to improve prediction performance on future values from multiple training examples using an online learning scheme. Initial results demonstrate excellent predictions that outperform results from literature and other neural network algorithms. Due to computing constraints in on-board vehicle systems, the authors develop online training with autonomous control of lag (window width). The control algorithm embeds in the model with rules that govern and adjust lag during training. This method ensures the minimization of computational cost and prediction errors with the use of standard computing equipment during driving conditions.
N-Type Calcium Channels Control GABAergic Transmission in Brain Areas related to Fear and Anxiety
Authors: Blazon Maxwell , LaCarubba Brianna , Bunda Alexandra , Czepiel Natalie , Mallat Shayna , Londrigan Laura , Andrade Arturo ,   Department of Biological Sciences, University of New Hampshire. 46 College Road, 245 Rudman Hall. Durham, NH, USA
Published: January 2021

N-type (CaV2.2) calcium channels are key for action potential-evoked transmitter release in the peripheral and central nervous system. Previous studies have highlighted the functional relevance of N-type calcium channels at both the peripheral and central level. In the periphery, N-type calcium channels regulate nociceptive and sympathetic responses. At the central level, N-type calcium channels have been linked to aggression, hyperlocomotion, and anxiety. Among the areas of the brain that are involved in anxiety are the basolateral amygdala, medial prefrontal cortex, and ventral hippocampus. These three areas share similar characteristics in their neuronal circuitry, where pyramidal projection neurons are under the inhibitory control of a wide array of interneurons including those that express the peptide cholecystokinin. This type of interneuron is well-known to rely on N-type calcium channels to release GABA in the hippocampus, however, whether these channels control GABA release from cholecystokinin-expressing interneurons in the basolateral amygdala and medial prefrontal cortex is not known. Here, using mouse models to genetically label cholecystokinin-expressing interneurons and electrophysiology, we found that in the basolateral amygdala, N-type calcium channels control ~50% of GABA release from these neurons onto pyramidal cells. By contrast, in the medial prefrontal cortex N-type calcium channels are functionally absent in synapses of cholecystokinin-expressing interneurons, but control ~40% of GABA release from other types of interneurons. Our findings provide insights into the precise localization of N-type calcium channels in interneurons of brain areas related to anxiety.
The Effect of Information and Communication Technology and Social Networking Site Use on Older People’s Well-Being in Relation to Loneliness: Review of Experimental Studies
Authors: Casanova Georgia , Zaccaria Daniele , Rolandi Elena , Guaita Antonio
Published: January 2021

Background

In the last decades, the relationship between social networking sites (SNSs) and older people’s loneliness is gaining specific relevance. Studies in this field are often based on qualitative methods to study in-depth self-perceived issues, including loneliness and well-being, or quantitative surveys to report the links between information and communication technologies (ICTs) and older people’s well-being or loneliness. However, these nonexperimental methods are unable to deeply analyze the causal relationship. Moreover, the research on older people’s SNS use is still scant, especially regarding its impact on health and well-being. In recent years, the existing review studies have separately focused their attention on loneliness and social isolation of older people or on the use of ICTs and SNSs in elderly populations without addressing the relationship between the former and the latter. This thorough qualitative review provides an analysis of research performed using an experimental or quasi-experimental design that investigates the causal effect of ICT and SNS use on elderly people’s well-being related to loneliness.

Objective

The aims of this review are to contrast and compare research designs (sampling and recruitment, evaluation tools, interventions) and the findings of these studies and highlight their limitations.

Methods

Using an approach that integrates the methodological framework for scoping studies and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for systematic reviews, we identified 11 articles that met our inclusion criteria. A thematic and content analysis was performed based on the ex post categorization of the data on the selected studies, and the data were summarized in tables.

Results

The analysis of the selected articles showed that: (1) ICT use is positively but weakly related to the different measures of older people’s well-being and loneliness, (2) overall, the studies under review lack a sound experimental design, (3) the main limitations of these studies lie in the lack of rigor in the sampling method and in the recruitment strategy.

Conclusions

The analysis of the reviewed studies confirms the existence of a beneficial effect of ICT use on the well-being of older people in terms of reduced loneliness. However, the causal relationship is often found to be weak. This review highlights the need to study these issues further with adequate methodological rigor.
Smartphone-Based Self-Reports of Depressive Symptoms Using the Remote Monitoring Application in Psychiatry (ReMAP): Interformat Validation Study
Authors: Goltermann Janik , Emden Daniel , Leehr Elisabeth Johanna , Dohm Katharina , Redlich Ronny , Dannlowski Udo , Hahn Tim , Opel Nils
Published: January 2021

Background

Smartphone-based symptom monitoring has gained increased attention in psychiatric research as a cost-efficient tool for prospective and ecologically valid assessments based on participants’ self-reports. However, a meaningful interpretation of smartphone-based assessments requires knowledge about their psychometric properties, especially their validity.

Objective

The goal of this study is to systematically investigate the validity of smartphone-administered assessments of self-reported affective symptoms using the Remote Monitoring Application in Psychiatry (ReMAP).

Methods

The ReMAP app was distributed to 173 adult participants of ongoing, longitudinal psychiatric phenotyping studies, including healthy control participants, as well as patients with affective disorders and anxiety disorders; the mean age of the sample was 30.14 years (SD 11.92). The Beck Depression Inventory (BDI) and single-item mood and sleep information were assessed via the ReMAP app and validated with non–smartphone-based BDI scores and clinician-rated depression severity using the Hamilton Depression Rating Scale (HDRS).

Results

We found overall high comparability between smartphone-based and non–smartphone-based BDI scores (intraclass correlation coefficient=0.921; P<.001). Smartphone-based BDI scores further correlated with non–smartphone-based HDRS ratings of depression severity in a subsample (r=0.783; P<.001; n=51). Higher agreement between smartphone-based and non–smartphone-based assessments was found among affective disorder patients as compared to healthy controls and anxiety disorder patients. Highly comparable agreement between delivery formats was found across age and gender groups. Similarly, smartphone-based single-item self-ratings of mood correlated with BDI sum scores (r=–0.538; P<.001; n=168), while smartphone-based single-item sleep duration correlated with the sleep item of the BDI (r=–0.310; P<.001; n=166).

Conclusions

These findings demonstrate that smartphone-based monitoring of depressive symptoms via the ReMAP app provides valid assessments of depressive symptomatology and, therefore, represents a useful tool for prospective digital phenotyping in affective disorder patients in clinical and research applications.
Feasibility and Acceptance of Telerehabilitation among Older Adults with Mild Cognitive Impairment or Cognitive Frailty: A Scoping Review (Preprint)
Authors: Md Fadzil Nurul Hidayah , Sahar Suzana , Rajikan Roslee , Kaur Ajit Singh Devinder , Mat Ludin Arimi Fitri , Subramaniam Ponnusamy , Ibrahim Norhayati , Vanoh Divya , Mohamad Ali Nazlena , Mohd Noah Shahrul Azman
Published: January 2021

BACKGROUND

Older adults are vulnerable towards cognitive frailty that can lead to adverse health outcomes such as cognitive frailty, falls, disabilities, hospitalizations and increased morbidity. With advancement of healthcare technology, there is a potential to manage and reverse cognitive frailty among older adults using a multi-domain intervention programme via telerehabilitation.

OBJECTIVE

In this review, we aimed to identify the feasibility and acceptance towards telerehabilitation and the common technology used for delivering telerehabilitation among older adults with mild cognitive impairment or cognitive frailty.

METHODS

Five research databases were searched: PubMed (EMBASE), Embase (Science Direct), Cochrane Database of Systematic Review, IEEE Xplore and Scopus. Articles published from January 2015 until October 2020 were selected. A hand search of JMIR Publications journals was also included

RESULTS

Of the 1758 articles retrieved, six studies were identified that involved implementation of telerehabilitation targeting older adults with cognitive frailty. Two articles were randomized controlled trials, one pilot study and three were qualitative studies. Telerehabilitation can improve quality of life among participants with mild cognitive impairment and cognitive frailty and found to be feasible as supportive digital platform in digital health care. Some types of technologies commonly used in the studies were smartphone or telephone with Internet, television-based assistive integrated technology, mobile application and videoconference.

CONCLUSIONS

Telerehabilitation utilization in managing cognitive frailty among older adults is still limited and more research is required to evaluate its feasibility and acceptability. Although telerehabilitation appears to be feasible and accepted among older adults with cognitive frailty, some social support in place is required. Future research should focus on evaluation of acceptance and cost effectiveness of multi-domain intervention via telerehabilitation among older adults with cognitive frailty.