bluuebunny/crossref_metadata_2025 huggingface dataset:
The Urgency of Local Culture-Based Basic Education Purwokerto
Authors: Darojah Rani
Published: December 2022

This study aims to analyze the need for locally charged education to improve the quality of education in the Purwokerto area. This research is a qualitative research where data sources were obtained through Focus Group Discussions (FGD) involving 25 education practitioners. as well as through a questionnaire given to 250 users, namely grade 1-6 elementary school students who were randomly selected in the Purwokerto area. The results of this study were obtained in the form of a strategic plan for Purwokerto local culture-based education, namely through equity and expansion of access to Purwokerto culture-based education, improving quality, relevance and competitiveness rooted in regional culture, strengthening accountability governance and public image as supporting elements. The conclusion of this research is in the form of recommendation considerations for education containing local wisdom, including equity and expansion of access to learning with local Purwokerto culture to make the identity and identity of education in Purwokerto, improving quality, relevance and competitiveness through unique characteristics in the form of education with regional cultural wisdom, and strengthening governance, accountability and public image regarding education based on local culture.
Dual control of lysogeny and phage defense by a phosphorylation-based toxin/antitoxin system
Authors: Wang Xiaoxue , Guo Yunxue , Tang Kaihao , Sit Brandon , Gu Jiayu , Chen Ran , Lin Jianzhong , Lin Shituan , Liu Xiaoxiao , Wang Weiquan , Gao Xinyu , Nie Zhaolong , Liu Tianlang , Waldor Matthew
Published: December 2022

Regulatory systems that maintain prophage quiescence integrate phage and host gene expression with environmental conditions1,2. In the opportunistic bacterial pathogen Pseudomonas aeruginosa, Pf filamentous bacteriophages play critical roles in biofilm formation and virulence3-5, but mechanisms governing Pf prophage activation in biofilms are largely unknown. Here, we report a new type of prophage regulatory module in a widely-distributed P. aeruginosa lineage that not only controls virion production of co-resident Pf prophages, but also mediates defense against diverse lytic phages. By comparing two lineages of the prototype P. aeruginosa strain PAO1 that harbor different Pf prophages, we identified a prophage-encoded kinase-kinase-phosphatase (KKP) system that controls Pf production in biofilms. KKP components exhibit dynamic stoichiometry, where high kinase levels in planktonic conditions maintain phosphorylation of the host H-NS protein MvaU, repressing prophage activation. During biofilm formation, phosphatase expression is heightened, leading to MvaU dephosphorylation and alleviating repression of prophage gene expression. KKP clusters are present in hundreds of diverse temperate prophages and other mobile elements across Gram-negative bacteria. Characterization of KKP modules from different species revealed that, in addition to regulating Pf phage lysogeny, KKP functions as a tripartite toxin-antitoxin system that mediates host defense from predatory lytic phages. KKP represents a new phosphorylation-based mechanism for prophage regulation and for phage defense. The dual function of this module raises the question of whether other newly described phage defense systems6-9 also regulate intrinsic prophage biology in diverse hosts.
A process evaluation of a pilot community health management information system in Mpongwe district of Zambia: lessons to inform strengthening of health information systems
Authors: Akinola Olatubosun , Zulu Joseph , Shakwelele Hilda , Mufana Carol , Banda Nelia , Katyoka Emmanuel , Chila Sylvia , Lubala Naomi
Published: December 2022

Background: Increased attention has been put towards developing and implementing Community Health Management Information System (c-HMIS). It is for this reason that in 2012, Ministry of Health (MoH) with the support from Clinton Health Access Initiative (CHAI) developed a Community Health Management Information System (c-HMIS) in Zambia. There is limited data on the implementation, acceptability and use of c-HMIS in community health systems. Guided by the by Atun’s framework on integration of interventions in health systems. We explored the implementation and acceptability of c-HMIS in Mpongwe district.
Methodology:Qualitative data collected with 66 respondents namely members of health committees, community health assistants and their supervisors were analysed using thematic analysis.
Results: The nature of the problem which included poor quality of data /information due to lack of standardized data collection tools and delayed submission of reports motivated MoH and stakeholders to adopt the c-HMIS. Theattributes of the c-HMIS Intervention such as the provision of improved data collection tools, training stakeholders in using the tools, the perceived simplicity of the system and factors within the adoption system such as some health workers being familiar with c-HMIS, compatibility of the c-HMIS with existing tools, as well as improved collaboration and communication among actors facilitated the adoption process. Further, health system characteristics such as timely availability of data and improved health information feedback processes, improved mapping of key health issues in communities; as well as the broader context such as community engagement promoted community ownership of the c-HMIS. The c-HMIS implementation barriers included challenges with completing some sections in the tools due to missing data, limited gender inclusiveness in the tools, inadequate availability of digital platforms to enter and store data, limited incentives for community health workers, poor phone network/ internet connection as well as the COVID-19 pandemic.
Conclusion: Strengthening the implementation and acceptability of c-HMIS may require introducing electronic data capture and transmission using simple digital tools such as android phones. Electronic systems would help address logical challenges related to inadequate data collection tools, data entry challenges, and delayed transmission of data.
Investigation of Group Dynamics in Video-conferencing Activity Facilitated by a Virtual Agent
Authors: Gordon Goren , Mizrahi Elinor , Danzig Noa
Published: December 2022

Small group activities have many educational advantages. In this contribution, we present a novel system for monitoring and analysing real-time group dynamics in a video-conferecing environment, with and without an autonomous virtual robot facilitator, which was programmed with group facilitation best practices. Groups of tenth-grade students interacted with the system, where we examined subjective perceptions of the activity, group dynamics and the facilitator, as well as analysed real-time speaker and facial expression recognition data. Our results show that students reported the activity with the virtual robot facilitator to be significantly more efficient, more understandable and more motivating of participation compared with activities without facilitation. Furthermore, students also spoke more, were happier and were significantly more engaged with virtual robot facilitation. Analyzing subjective and object measures showed significant correlations between the students' perceptions of the group activity and their own participation in it. Finally, it was found that group dynamics, as measured by time-series speaker and facial expression data, can be clustered into groups with similar behavioural characteristics and that facilitation with a virtual robot facilitator changed these dynamics. This study suggests that online group activities, facilitated by an autonomous virtual agent, are a promising tool to investigate group dynamics in educational scenarios.
Assessment of bacteriological quality of raw bulk milk of camel, cow and goat from local markets in Yabello District, Borana Zone, Oromia Regional State
Authors: Mohammed Temesgen , Zewude Aboma
Published: December 2022

Background: The study was conducted from September 2020 to June 2021to assess the bacteriological quality of raw bulkmilkfrom urban and rural local market sites in Borana pastoral area of Oromia Regional State, Southern Ethiopia. A total of 78 milk samples were collected and analyzed for bacterial load using standard plate count and coliform count techniques and isolation of pathogenic bacteria was conducted.
Results: The total mean aerobic bacterial counts of raw bulk milk samples of camel, cow and goat were 8.51 log cfu/ml, 8.73 log cfu/ml and 8.54log cfu/ml respectively. Regarding the location of milk market sites the mean total aerobic bacterial count was 8.72 log cfu/ml and 8.49 log cfu/mlin urban and rural milk market sites respectively. The total mean coliform counts of raw bulk milk samples of camel, cow and goat were6.51log cfu/ml, 6.55 log cfu/ml and 6.47 log cfu/ml respectively. Regarding the location of milk market sites the total mean coliform counts was 6.63 log cfu/ml and 6.40log cfu/ml from urban and rural milk market sites respectively.Comparing the mean differences of the total mean aerobic and coliform bacterial counts, there was no significant mean differences (p>0.05) among the animal milk samples. However, there was significant mean differences (p<0.05) among the milk market sites.
Conclusions: Different bacterial species were isolated from camel, cow and goat raw milk sample from the urban and rural milkmarket sites. The major bacterial isolates were Staphylococcus (both pathogenic and non-pathogenic), Escherichia coli and Bacillus species. Generally the unhygienic milk handling resulted in poor milk quality in the pastoral area. Therefore there is a need of training for persons at the various milk market siteson strict hygienic measures to improve the bacteriological safety of cow milk.
WITHDRAWN: SHOX variations in Idiopathic Short Stature in North India and its overall prevalence in Asia
Authors: Srivast Priyanka , Tyagi Ankita , Bamba Chitra , Kumari Anu , Kaur Harvinder , Seth Saurabh , Kaur Anupriya , Panigrahi Inusha , Dayal Devi , Pramanik Subhodip , Mandal Kausik
Published: December 2022

Background
Short stature homeobox (SHOX) haploinsufficiency underlies idiopathic short stature (ISS) and Leri-Weill dyschondrosteosis (LWD). The worldwide prevalence of SHOX variations in ISS varies from 2.5–15%. This study aims to assess the implication of SHOX variation in ISS in North India and its overall prevalence in Asian population.
Methods
SHOX gene analysis carried out by Multiplex ligation dependent probe amplification (MLPA) followed by Sanger sequencing in 54 patients with variable phenotypes. Meta-analysis was done to evaluate its prevalence which comprises 11 previous studies including present, carried out on a total of 979 participants.
Results
SHOX gene analysis resulted in 12.9% of positivity (7.4% deletions and 5.5% duplications). SHOX association was seen significantly related to gender, with predominance in female sex (P-value: 0.047). Short arms and forearms were the only significantly associated trait seen in 51.85% of children. We have found a rare association of multiple exostosis with LWD in a child with deletion. The prevalence of SHOX variation came as 15.2% in Asians. No significant difference was found in geographical region-specific analysis.
Conclusion
This meta-analysis compiles findings from the last decade and provides an updated picture of the prevalence of SHOX variations in Asians, emphasizing their potential as therapeutic targets in ISS patients.
Comparative effect of natural and chemical farming systems of apple production on soil physio-chemical properties, leaf mineral content and fruit quality
Authors: Pathania Sweta , Kumari Neelam
Published: December 2022

The present study was conducted to compare the effects of natural and chemical farming system of apple production on soil, leaf nutrient status and fruit quality. Experiment was conducted in ten commercial apple orchards; five under natural farming system of apple production and adjacent to them, five were under chemical farming system of apple production for comparison. Leaf nutrient status, soil physio-chemical properties and fruit quality under both the farming systems were evaluated. The results indicated significant difference in the primary (N, P, K) and secondary (Ca, Mg) macronutrient status of leaf and soil samples collected from the study orchards (p < 0.05). Among micronutrients, status of Cu and Zn were recorded to be significantly different in both the farming systems whereas, Fe and Mn were recorded to be non-significant. Soil pH and EC were recorded to be higher (6.12, 0.48 dS m− 1) in CFS than NFS (5.77, 0.38 dS m− 1), while OC was reported to be higher (2.03%) in NFS than CFS (1.78%). However, only OC was found to be significant. Fruit length, breath, weight and TSS showed significant difference in both the farming systems. Mean fruit length, breadth, weight, and acidity was recorded to be higher (65.80 mm, 71.62 mm, 159.65 g, 0.64%) in CFS than NFS (58.87 mm, 62.72 mm, 122.41 g, 0.48%). While firmness and TSS were recorded to be higher (6.95 kg inch− 2, 12.27 ᵒBrix) in NFS than CFS (5.64 kg inch− 2, 10.91 ᵒBrix). It can be concluded that nutrient status of soils and leaves was higher in CFS. This may be due to small sample size studied and the orchardists selected were practicing natural farming from only 4 years.
Clinical features and prognostic factors of adult patients with hemophagocytic lymphohistiocytosis: a retrospective study of 130 adult patients
Authors: Xu Tingting , Tang Liang V. , Xiong Lijuan
Published: December 2022

Background Hemophagocytic lymphohistiocytosis (HLH) is a syndrome with high mortality rate that is becoming increasingly common in adults in recent years. The mechanism of HLH in adults is poorly understood. This single-center study focused on the clinical features and prognostic factors of adult HLH patients.
Methods We reviewed the medical records of adult HLH patients (age≥15 years) diagnosed and treated at our institution from 2013 to 2022. Patients were followed from index date of prescription until death, or until August 31, 2022. Cox regression analysis was used to estimate hazard ratios (HR) and 95% confidence intervals (CI).
Results 130 (78 men, median age, 46 years) satisfied the HLH-2004 diagnostic criteria and were included in the study. 57 (43.8%) patients were malignancy-associated HLH. The median OS of the cohort was 61 days (95% CI 14–108). According to a multivariate Cox retrospective analysis, malignancy-associated HLH (HR=2.421, 95% CI 1.107–2.631, P=0.016) predicted a poorer outcome. Lower platelet count was related with both 30-day mortality (HR=0.987, 95% CI 0.976–0.998, P=0.018) and overall mortality (HR=0.993, 95% CI 0.987–0.999, P=0.019). The adoption of etoposide-related regimens reduced 30-day mortality (HR=0.453, 95% CI 0.252–0.815, P=0.008) and was strongly correlated with a better outcome (HR=0.629, 95% CI 0.407–0.972, P=0.037).
Conclusion Our study demonstrated that early diagnosis of HLH and identification of the underlying causes are crucial, low platelet count predicts poor outcome, and that therapy with etoposide dramatically improved prognosis.
Deep Learning Model on 2-Dimensional Image Data using Convolutional Autoencoder and Fully Connected Neural Networks: Application to Computational Fluid Dynamics
Authors: Yoon Jaehyun , Doh Jaehyeok
Published: December 2022

This study proposes a deep-learning-based image prediction meta-modeling method to develop an image-based approximate optimized design using 2D image data. An image-based meta-model is generated with an autoencoder (AE) and fully connected neural networks (FNN). To create this meta-model, we suggested three methods as FNN-based AE, convolutional autoencoder (CAE) based on convolution neural networks (CNN), and hybrid-convolutional autoencoder (H-CAE) combining the FNN and CAE. To verify the proposed methods, we applied them to predict the pressure distribution for around a 2-dimensional airfoil to replace the computational fluid dynamics simulation. As a result, the H-CAE among the proposed methods shows the high prediction accuracy, 99.9811% of the best image reconstruction rate for the pressure distribution around the airfoil. Therefore, H-CAE offers the best learning capability. There is an advantage that the latent can be predicted using shape parameters of an airfoil as inputs via the FNN based on the latent with the compressed image data.
Groundwater Risk Assessment in Imo River Basin of Southeast Nigeria using GIS-based DRASTIC and GOD
Authors: Emberga Terhemba , Opara Alexander , Onyekuru Samuel , Omenikolo Alexander , Bilar Ali , Unegbu Chika , Dominic Anuforo , Emeka Epuerie
Published: December 2022

Using the DRASTIC and GOD Techniques, a thorough evaluation of the aquifer vulnerability in the Imo River Basin, Southeast Nigeria, was conducted. The goal of the current study is to evaluate the two methods' capability for evaluating aquifer vulnerability in the study area by contrasting them. In contrast to the DRASTIC model, which assesses aquifer vulnerability using seven hydro-geological parameters, the GOD model estimates groundwater vulnerability across large regions based on just three parameters, including groundwater confinement, overlying strata, and depth to groundwater (depth to water, net recharge, aquifer media, soil media, topography, impact of vadose zone, and hydraulic conductivity). These index approaches used a variety of meteorological, geological, and hydro-geological observations to gather their data. The GOD and DRASTIC Indices were computed using sieve analysis to assess the hydraulic conductivity of the various strata covering the aquifers. The study's findings showed that the DRASTIC Index (DI) has a range of 76 to 192 with a mean value of 140.8. The Benin Formation has a mean DI of 162, which indicates high susceptibility, whereas the Ajali and Ameki Formations were determined to have average moderate vulnerabilities with DI values of 101 and 139, respectively. The Imo Shale, Ogwashi, and Nsukka Formations were calculated to have mean DI values of 76, 77, and 85, respectively, indicating modest aquifer vulnerability. The GOD Index across the study area ranged from 0.1 to 0.504 with a mean value of 0.328, it was also discovered. The mean GOD Index for the Benin Formation is 0.504, indicating high susceptibility, while the GOD Index values for the Ajali and Ameki Formations were assessed to be 0.105 and 0.112, respectively, indicating low vulnerability. Low vulnerability was identified for the Imo Shale, Nsukka, and Ogwasi Formations, with GOD Index values of 0.15,0125 and 0.1, respectively Due to its shallow aquifer depth and loose, uncompacted character, our data suggest that the Benin Formation has the highest vulnerability levels. Therefore, serious efforts should be made to keep an eye out for any potential anthropogenic pollution of the research area's aquifers.
Male Mortality from Sensitive Conditions to Primary Care from the Brazilian National Men’s Health Policy’s Perspective
Authors: de Paula Cácia Régia , Pelazza Bruno Bordin , de Lima Flavio Henrique Alves , Maia Ludmila Grego , de Araújo Reila Campos Guimarães , Tacsi Yolanda Rufina Condorimay , Ferri Lucila Pesuti , Meireles Gláucia Oliveira Abreu Batista , Ferreira Pedro Lopes , Sousa Ana Luiza Lima , Matos Marcos André , Barbosa Maria Alves
Published: December 2022

To assess male mortality trend and its relationship with conditions sensitive to primary care (CSPC), considering Family Health Strategy (FHS) coverage and Brazilian National Policy for Comprehensive Men’s Health Care (PNAISH) implementation. This is an ecological time series study of male deaths, aged 20 to 59 years, according to CSPC, from 2009 to 2018. The relationship between CSPC mortality and FHS coverage was quantified by Spearman’s correlation. The trend in the number of deaths was adjusted by univariate Quasi-Poisson Regression models. CSPC accounted for 1,092,070 (19.2%) deaths in the municipalities, with an annual variation from − 4.89–3.06% and did not show a significant relationship with mean FHS coverage (r < 0.09; p < 0.160). FHS coverage showed a significant upward trend [95% CI; 1.03–1.09]. The trend of deaths in the study groups due to CSPC was generally stable (Exp (β) = 1.01; p > 0.593). FHS coverage expansion and the fact that PNAISH was implemented in all municipalities in the state of Goiás did not influence death rates due to CSPC in general.
Dietary guanidine acetic acid addition improved carcass quality with less back-fat thickness and remarkably increased meat protein deposition in rapid-growing lambs fed different forage types
Authors: Li Wen-Juan , Jiang Yao-Wen , Cui Zhao-Yang , Wu Qi-Chao , Zhang Fan , Chen He-Wei , Wang Yan-Lu , Wang Wei-Kang , Lv Liang-Kang , Xiong Feng-Liang , Liu Ying-Yi , aisikaer ailiyasi , Li Sheng-li , Bo Yu-Kun , Yang Hongjian
Published: December 2022

Background: The aim of this study was to investigate whether guanidine acetic acid (GAA) yields a response inrapid-growing lambs depending on forage type. In this study, seventy-two small tailed Han lambs (two months old; initial body weights = 12 ± 1.6 kg) were used in a 120-d feeding experiment after a 7-d adaptation period. A 2 × 3 factorial experimental feeding design was applied to the lambs, which were fed total mixed ration with two forage types (OH: oaten hay; OHWS: oaten hay plus wheat silage) and three forms of additional GAA (GAA: 0 g/kg; UGAA: Uncoated GAA, 1 g/kg; CGAA: Coated GAA, 1 g/kg).
Results: The OH diet had greater dry matter intake, average daily gain, and hot carcass weight than OHWS diet. The GAA supplementation increased final body weight, hot carcass weight, dressing percentage, and ribeye area in longissimus lumborum. Meanwhile, decreased backfat thickness and serum triglycerides in GAA fed lambs may through increasing hormone sensitive triglyceride lipase (HSL). Dietary GAA decreased the pH value, elevated the water-holding capacity (by reducing drip loss and cooking loss) in mutton. In addition, the crude protein content in mutton increased with GAA addition may through regulation with PIK3C3 /Akt1/mTOR signaling pathway.
Conclusions: Dietary GAA (UGAA or CGAA) might be an effective additive in lamb fed different forage types, as it has potential to improve growth performance and meat quality.
Optimizing the risk stratification of astrocytic tumors by applying the cIMPACT- NOW Update 3 signature: real-word single center experience
Authors: Molica Carmen , Pierini Tiziana , Gili Alessio , Nardelli Carlotta , Arniani Silvia , Mavridou Elena , Gorello Paolo , Corinaldesi Rodolfo , Metro Giulio , Giovenali Paolo , Castrioto Corrado , Lupattelli Marco , Roila Fausto , Mecucci Cristina , Starza Roberta La
Published: December 2022

Purpose. Implementation of a useful genetic diagnosis for the clinical management of patients with astrocytic tumors.Methods. We investigated 314 prospectively recruited diffuse astrocytic tumours by applying the cIMPACT-NOW Update 3 signature.Results. The cIMPACT-NOW Update 3 (cIMPACT 3+) markers, i.e. alterations of TERT promoter, EGFR, and/or chromosome 7 and 10, characterized 98.5% of IDH-wt cases. Interestingly, it was also found in 57.5% of IDH-mut cases. According to the genomic profile, four genetic subgroups could be distinguished: 1) IDH-wt/cIMPACT 3-negative (=4); 2) IDH-mut/cIMPACT 3-negative (n=14); 3) IDH-mut/cIMPACT 3+ (n=20); and 4) IDH-wt/cIMPACT 3+ (n=276). Multivariate analysis confirmed that IDH1/2 mutations confer a favorable prognosis (IDH-wt, HR 2.91 95%, CI 1.40-6.05), and validated the prognostic value of the cIMPACT 3+ signature.Conclusions. To accurately identify relevant prognostic categories, overcoming the limitations of histopathology and immunohistochemistry, molecular-cytogenetic analyses must be fully integrated into the diagnostic work-up of astrocytic tumors.
Phosphocreatine protects against diabetic retinopathy via improving mitochondrial functions bioenergetics through JAK2/STAT3 signaling pathway in Vivo and in Vitro
Authors: Qaed Eskandar , Zaky Mohamed Y. , Chu Peng , Yafei Saeed , Belal Amany , Abourehab Mohammed A.S. , Almoiliqy Marwan , Li Hailong , Al-Maamari Ahmed , Sultan Marwa , Wang Fu Han , Fang Jia Ni , Tang Zeyao , Sun Zhaolin
Published: December 2022

The most prevalent chronic consequence of diabetes mellitus is diabetic retinopathy (DR), a clinically microvascular disease characterized by damage to retinal capillaries with subsequent visual deterioration or blindness. DR is mainly attributed to hyperglycemia-induced retinal microvascular damage, however, emerging research has demonstrated that it is intimately linked to mitochondrial energy shortage and raises the generation of reactive emerging research has demonstrated that it is intimately linked to mitochondrial energy shortage and raises the generation of reactive oxygen species (ROS). This study is aimed to develop and investigate methods to safeguard DR membrane composition, such as regaining methods to safeguard DR membrane composition, such as regaining mitochondrial function. Controlling for hyperglycemia cannot reverse the pathologic changes induced by diabetes in the retinal mitochondria. In mitochondria damaged by hyperglycemia, we proposed that phosphocreatine (PCr) might enhance oxidative phosphorylation and electron transport capability. Similarly, we anticipated estimating PCr's protection against DR via the JAK2/STAT3 signaling pathway. PCr has a crucial metabolic function in DR cells, which includes controlling the intracellular content of ATP. Rat mitochondria and RGC-5 cells were evaluated for capacity using high-resolution respirometry (HRR). The expression of JAK2/STAT3 signaling pathways and apoptotic proteins were detected using western blotting. We assessed ROS production and mitochondrial membrane potential (MMP) in Wistar male rats with streptozotocin induced-diabetes. In this study, we found that PCr had protective effects against DR injury by boosting mitochondrial bioenergetics and preventing DR by easing the symptoms of diabetes and improving biochemical indicators. Additionally, PCr decreased the expression of Bax, cleaved caspase 3, cleaved caspase 9, as well as the JAK2/STAT3 signaling pathway while increasing the expression of Bcl-2, caspase 3, and caspase 9 proteins. In Conclusions when exposed to oxidative stress caused by hyperglycemia, PCr improves mitochondrial activity and has antiapoptotic effects in vivo and in vitro through the JAK2/STAT3 signaling pathway. These findings suggest that PCr is a potentially effective therapeutic approach for diabetic retinopathy.
A longitudinal study of sexual activity and influencing factors in breast cancer patients during treatment: a trajectory analysis model
Authors: ZHANG Tian , ZHANG Xiaolu , Yang Jing , Wen Min , Liao Jiaqian , Chen Shouli , Wang Yingyin , DENG Xiaoyuan , LIU Xiaoyan , WANG Guorong
Published: December 2022

Purpose: To describe the longitudinal track of sexual activity in patients with breast cancer during treatment and its influencing factors.
Methods: A prospective longitudinal study was conducted to investigate 225 patients who were first diagnosed with breast cancer in A tumor specialty three-class hospital in Southwest China. 225 patients were evaluated for sexual activity at the time of admission and diagnosis (T0) and one month (T1), three months (T2), six months (T3), and nine months (T4) after diagnosis.
A trajectory analysis model (GBTM) was used to explore the changes in sexual activity in breast cancer patients. Logistic regression analysis was used to analyse the factors that affected the classification of sexual activity trajectories.
Results: The ratio of sexual activity abruptly declined from 100% at baseline to 39.1% at T1. The percentage of sexual activity was improved, from 51.4% at T2 to 63.1% at T4. The optimal model was a 2-group trajectory of sexual activity in breast cancer patients,36.6% in the "low activity group" and 63.4% in the "high activity group." The factors influencing the grouping of sexual activity trajectories were aging (β=0.751, P=0.004), sexual desire at baseline (β=0.724, P=0.003), and vaginal lubrication (β=1.177, P<0.001).
Conclusions: Research has demonstrated that the sexual activity level of breast cancer patients decreases in early stage and increases over time. Moreover, we observed that breast cancer patients had better libido and vaginal lubrication before the disease, especially those older than 50. At the same time, we suggest that the level of sexual activity in young breast cancer patients is a tremendous worthy concern during clinical work. Efficient interventions of sexual activity in advance of treatment may help to improve the sexual health of these patient populations.
Implications for cancer survivors：There is a need to re-examine the evaluation steps of sexual function in breast cancer patients and provide targeted intervention services for patients.
Molecular Structure of 2-hydroxy-5-methyl-2-nitroazobenzene Isomer: DFT Insight
Authors: Nainggolan Fernando
Published: December 2022

It is currently thought that azobenzene molecules exist in trans and cis form of molecular structure configuration. Affirmation supporting this perspective has been substantially derived by theoretical results in the isomerization process. However, whether these molecular structures may affect the electronic properties entirely need to be confirmed. In this study, I give my effort to understand the molecular structure properties of trans and cis form of azobenzene molecule from 2-hydroxy-5-methyl-2’-nitroazobenzene (HMNA). Their chemistry phenomena are investigated using density functional theory (DFT) method. According to this study, it show that the molecular size of trans form of HMNA is 9.0 Å and cis form of HMNA is 6.6 Å, have electronic transition of π → π* type driven by azo bond in trans-HMNA whereas C = C bond on the benzene ring offers higher contribution for cis-HMNA and also cis-HMNA shows n → π* type with respect to the non-bonding electrons of oxygen and nitrogen atoms while trans-HMNA form does not show any significance. Therefore, this molecule system as a push-pull molecule system contributes to the chemistry properties and phenomenon for molecular structure, electronic transition and mechanism pathway of trans to cis isomer formation in the ground state.
WITHDRAWN: DSBAL: Distributed Stacked Bidirectional Attention-based LSTM Method for Time Series Forecasting
Authors: Prakash N. , G Sumaiya Farzana.
Published: December 2022

Accurate time series forecasting is crucial to increase the performance and turnover of every business. However, It’s quite a difficult task due to the non-stationary and high level of uncertainty in the time series data. This paper proposes a new method called the Distributed Stacked Bidirectional Attention Long Short-Term Memory Neural Network (DSBAL) for time series forecasting. The DSBAL method combines the Stacked Bidirectional LSTM (SBiLSTM) and Attention mechanism in distributed computing. The proposed method consists of an SBiLSTM encoder, attention mechanism, and SBiLSTM decoder. SBiLSTM encoder is used to extract the complex features in the daily tomato supply data, in addition, the Attention mechanism is introduced to enhance the performance of SBILSTM by selecting the more appropriate sequence in the data by giving higher weightage to them. SBiLSTM decoder uses the most appropriate sequences from the attention mechanism to predict the daily tomato supply data. The entire process of the proposed method runs in distributed computing to improve efficiency, accuracy, and scalability. Our proposed method allows us to use only appropriate sequences in the data, captures complicated patterns, and addresses computational issues. To prove the efficiency of the proposed methodology, the experiments are conducted with other time series forecasting methods like RNN, LSTM, Stacked LSTM, Bidirectional LSTM, and Attention LSTM using daily tomato supply datasets in terms of SMAPE and RMSE. The results obtained from the experiment demonstrate that our proposed method is more efficient, accurate, and scalable.
WITHDRAWN: KNOWLEDGE AND OPINIONS OF TURKISH UNIVERSITY STUDENTS REGARDING THE USE OF CONTRACEPTIVE METHODS: A QUALITATIVE STUDY
Authors: PAŞA Büşra KÜÇÜKTÜRKMEN , TARUS Hamide ARSLAN , SUVEREN Yaşar , TURAN Zekiye
Published: December 2022

Aim: This study aimed to identify the knowledge and views of university students regarding the use of contraceptive methods.
Materials and Methods: The study, in which a qualitative research method was applied, was conducted with 38 students studying at a university in the Marmara Region of Türkiye. Data were collected via semi-structured interviews and participant information forms and were evaluated using the content analysis technique.
Results:Based on the interviews with the students, four main themes were determined: “Personal opinions on the use of contraceptive methods,” “Opinions on social perspectives on the use of contraceptive methods,” “Knowledge and awareness about contraceptive methods,” and “Suggestions and expectations for contraceptive methods.”
Conclusion: Although these university students were ill-informed about contraception, they held positive views on the use of contraceptive methods and they disagreed with the prevailing societal views. The organization of educational programs to increase young people’s knowledge of contraceptive methods may contribute to the protection and improvement of sexual and reproductive health.
Non-autoimmune overt hypothyroidism in the early stages of nephrotic syndrome: A case report from Somalia
Authors: Siyad Mohamed Osman , Adan Abdisamad Mohamed , Jeele Mohamed Osman Omar
Published: December 2022

Nephrotic syndrome (NS) was first characterized in 1827 as the occurrence of proteinuria greater than or equal to 3.5 g/24 hours, hypoalbuminemia (albumin less than or equal to 3.0 g/dl), peripheral edema, hyperlipidemia, lipiduria caused by increased permeability of the renal glomerulus. In the early stage of NS the loss of thyroid hormones rarely leads to hypothyroidism and euthyroid state is expected. However, persistent proteinuria will eventually lead to hypothyroidism. Non-autoimmune hypothyroidism due to NS which presents at an early stage of NS is quite rare and cases reporting it are very scarce in the literature. In the presenting case, we reported a 26-year-old male patient with no known history of chronic disease who presented to the emergency department with a complaint of one-week generalized edema, nausea, fatigue, and generalized ache in the extremities. He was diagnosed with nephrotic syndrome complicated by hypothyroidism and was hospitalized for 3 weeks. After 3 weeks of treatment and close monitoring, the patient’s clinical condition and laboratory investigations were improved and was discharged in good health.
Molecular Dynamics Simulation of Atomic Interaction between Main Protein of Human Prostate Cancer and Fe/C720 Buckyballs-Statin Structures
Authors: Panah Mohammad Pour , Sabetvand Roozbeh
Published: December 2022

Background and Objective
Atomic interaction between main protein of Human Prostate Cancer (PHPC) and Fe/C720 Buckyballs-Statin is important for medical science. For the first time, we use Molecular dynamics (MD) approach based on Newton's formalism to describe the destruction of HPC via Fe/C720 Buckyballs-Statin with atomic accuracy.
Methods
In this work, the atomic interaction of PHPC and Fe/C720 Buckyballs-Statin introduced via equilibrium molecular dynamics approach. In this method, each PHPC and Fe/C720 Buckyballs-Statin is defined by C, H, Cl, N, O, P, S, and Fe elements and contrived by Universal Force Field (UFF) and DREIDING force-field to introduce their time evolution.
Results
The results of our studies regarding the dynamical behavior of these atom-base compounds have been reported by calculating the Potential energy, center of mass (COM) position, diffusion ratio and volume of defined systems. The estimated values for these quantities show the attraction force between Buckyball-based structure and protein sample, which COM distance of these samples changes from 10.27. Å to 2.96. Å after 10 ns. Physically, this interactions causing the destruction of the PHPC. Numerically, the volume of this protein enlarged from 665276 Å3 to 737143 Å3 by MD time passing. This finding reported for the first time which can be considered by the pharmaceutical industry.
Conclusion
Volume of the PHPC increases by Fe/C720 Buckyballs-Statin diffusion into this compound. By enlarging this quantity (diffusion coefficient), the atomic stability of PHPC decreases and protein destruction procedure fulfilled.
Due to forgetting to take antihypertensive medication, a hypertensive emergency occurred: A Case Report and Discussion
Authors: Bereda Gudisa
Published: December 2022

A life-threatening condition known as a "hypertensive emergency" is marked by a severe increase in blood pressure together with acute or significant target organ damage. On June 1, 2022, a 67-year-old black male farmer was admitted to the emergency department with a major chief complaint of breathing difficulty. The patient was traveling to the village for work and forgetting his medication at home, and he was losing consciousness and motor activity at his workplace. He presented with symptoms of shortness of breath, confusion, dizziness, nausea, vomiting, blurred vision, and faintness. An abnormal cardiac region was visible on chest X-rays, and there were no changes to the pulmonary parenchyma or fluid overload. Upon admission, hydralazine (5 mg) intravenously was administered immediately, and he was reassessed after 20 minutes and kept at the emergency department. The next day, sustained-release nifedipine (20 mg) was initiated orally twice a day for the patient, and he was transferred to the medical ward. In the medical ward, the patient was assessed for four days, and in those four days, he showed marked improvement. Hypertensive emergency treatment intends to reverse target organ damage, readily lowering blood pressure, decreasing adverse clinical complications, and enhancing the quality of life.
Modeling the Omicron Dynamics and Development in China with a Deep Learning Enhanced Compartmental Model
Authors: Deng Qi , Wang Guifang
Published: December 2022

Background: The mainstream compartmental models require stochastic parameterization to estimate the transmission parameters between compartments, which depends upon detailed statistics on epidemiological transmission characteristics that are economically and resource-wide expensive to collect. As an alternative, deep learning techniques are effective in estimating these stochastic parameters with greatly reduced dependency on data particularity.
Methods: We apply deep learning to estimate transmission parameters of a customized compartmental model, then feed the estimated transmission parameters to the compartmental model to predict the development of the Omicron epidemics in China for 28 days.
Results: In China mainland, the daily Omicron infection increase is between 60 and 260 in the 28-day forecast period between June 4 and July 1, 2022. On July 1, 2022, there would be 768,622 cumulative confirmed cases and 591 cumulative deceased cases. The average levels of predication accuracy of the model are 98% and 92% for number of infections and deaths, respectively.
Conclusions: The effectiveness of prevalent compartmental modes depends upon detailed statistics on epidemiological transmission characteristics. As an alternative, deep learning techniques are effective in estimating these stochastic parameters with greatly reduced dependency on data particularity. Our model demonstrates the efficacy and potential of applying deep learning methodologies in predicting the dynamics of infectious diseases.
Green Brand as a New Pattern of Energy-Efficient Consumption
Authors: Chygryn Olena , Kuzior Aleksandra , Uzik Jan , Olefirenko Oleg
Published: December 2022

In the conditions of the spread of globalization processes, growing interdependence, and interconnectedness of countries, a significant intensification of the academic society efforts to ensure national energy security and independence is necessary. The purpose of the paper is to provide a systematic review of the scientific environment aimed at analysing the contents and features of scientific publications dealing with new trends and patterns in sustainable energy consumption. In order to create a semantic and definition basis and research the main trends of scientific publications on the subject of developing energy efficiency and sustainable consumption, the paper carried out a bibliometric analysis concerning the categories «energy efficient» and «energy consumption» using the Scopus and VOSviewer tools. The main question is, what are the main scientific and research trends and patterns in the field of energy efficiency and sustainable consumption? For this purpose, the quantity and quality tendencies of the scientific articles which are studying issues connected with energy efficiency and sustainable consumer behaviour were determined. A sample of more than 24000 scientific publications on this issue was generated from publications indexed by the Scopus database. The study period covers 2001-2021. On the global level, the analysed investigated area is represented by the countries: China, the USA, and India. VOS viewer tools were used to systemize 5 clusters of scientific articles that analysed sustainable energy consumption from different points of view. Identification of regularities in the developing of scientific approaches to energy-efficient consumption and developing sustainable energy sector was carried out using bibliometric analysis, which has made it possible to describe the dominant retrospective evolutionary and temporal tendencies in the development of this theory concerning the concepts of sustainable development, environmental management, and development of renewables. As a result, one of the most significant trends is a green brand and tendencies connected with developing green marketing and green consumer awareness.
Management of Innovations in Public Administration: Strategies to Prevent the Participation of Financial Intermediaries in Shadow Operations
Authors: Kuznyetsova Angela , Tiutiunyk Inna , Panimash Yuliia , Zsolt Zsombori , Zsolt Pal
Published: December 2022

This article summarizes the arguments and counterarguments within the scientific discussion on improving public administration tools in the context of implementing innovative mechanisms for combating shadow financial transactions. The main purpose of this research is to formalize innovative strategies to counter the shadow withdrawal of capital with the participation of financial intermediaries. The systematization of scientific sources and approaches to solving the problem of the de-shadow economy proved that a characteristic feature of the functioning of the shadow market is the active participation of financial intermediaries in shadow operations. The information base is data from the World Bank and the Organization for Economic Cooperation and Development, the Group for the Development of Financial Measures to Combat Money Laundering, Transparency International, and the World Economic Forum. The period of the study is 2003-2021. The EU countries, Ukraine, Moldova, and Montenegro, as candidate countries for EU membership, were selected as the object of the study. This study applied the methods of bibliometric analysis to generalize the existing scientific work on the investigated issue, analysis of changes in the number of search changes on the problems of shadowing the economy, and clustering regions by the number of search queries on the shadow economy. Intellectual data analysis methods (one-dimensional branching CART and agglomeration methods) were used for clustering countries depending on the nature of the policy of countering the shadowing of the economy. Based on the results of the bibliometric analysis, theories describing the shadow economy, in particular: innovation theory, the theory of centralization, and institutional theory, were summarized. The article presents the results of cluster analysis, which proved the practicality of selecting three clusters of countries: cluster 1 – Cyprus, Czech Republic, Denmark, Finland, Greece, Ireland, Italy, Luxembourg, and Portugal; cluster 2 – Bulgaria, Croatia, Estonia, France, Malta, Netherlands, Spain, Sweden, Belgium, Greece, Austria, Hungary, and Slovak Republic, Slovenia; cluster 3 – Lithuania, Latvia, Romania, Poland, Moldova, Montenegro, and Ukraine. The study empirically confirmed and theoretically proved that the entire set of innovative scenarios for implementing economic de-shadowing policy could be divided into three types (evolutionary scenario, sequential transformation scenario, and forced scenario). The above scenarios depend on the speed of change in the indicators of developing the shadow economic sector and their sensitivity to the implemented measures.
Innovative Foreign Direct Investment Policy: Latvia’s Case
Authors: Simelyte Agne , Tvaronaviciene Manuela
Published: December 2022

As globalization accelerates, the influence of innovative foreign capital on economic development and employment level becomes more significant. However, the impact of FDI on the standard of welfare and economic development is controversial. The demand to promote or target innovative FDI has increased as it has been seen as an innovative tool to stimulate regions’ economic growth or intervene in economic structure changes by orienting it in the most favourable way for the host country. Interest in attracting foreign direct investment has increased since the 1980s as it is one of the external financing sources for both developing and developed countries. However, scientists still argue whether the impact of foreign capital on economic growth is positive or negative. Some researchers state that inward FDI is limited to a short-term positive impact. In contrast, others maintain that the performance of multinational corporations cannot harm the host country at all, and FDI only positively influences economic growth. Modern economic science questions whether it is worthwhile for the state to interfere with the market and stimulate the identified target business sectors with the help of innovative FDI policy. In this way, even significant market flaws are revealed, and some companies are doomed to fail. The benefits of FDI are obvious: the creation of new jobs, «know-how», and the tendency to increase exports. In this sense, the host country should attract specific MNCs motivated towards expanding business through research and development. The article proposes a targeted, complex, innovative FDI policy while applying the ANP method. The methods applied in this research include Analytic Networking Method based on the SWOT approach. The ANP has been chosen as a qualitative method based on the experts’ opinion, allowing determining the best or several alternatives. The findings & value added of the study demonstrated that to gain a competitive advantage, Latvia should attract more innovative FDI into the service business area, followed by manufacturing. The research contributes to the internalization theory while emphasizing the importance of promoting innovative FDI.