bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring code portability solutions for HEP with a particle tracking test code
Authors: Ather Hammad , Berkman Sophie , Cerati Giuseppe , Kortelainen Matti J. , Kwok Ka Hei Martin , Lantz Steven , Lee Seyong , Norris Boyana , Reid Michael , Reinsvold Hall Allison , Riley Daniel , Strelchenko Alexei , Wang Cong
Published: October 2024

Traditionally, high energy physics (HEP) experiments have relied on x86 CPUs for the majority of their significant computing needs. As the field looks ahead to the next generation of experiments such as DUNE and the High-Luminosity LHC, the computing demands are expected to increase dramatically. To cope with this increase, it will be necessary to take advantage of all available computing resources, including GPUs from different vendors. A broad landscape of code portability tools—including compiler pragma-based approaches, abstraction libraries, and other tools—allow the same source code to run efficiently on multiple architectures. In this paper, we use a test code taken from a HEP tracking algorithm to compare the performance and experience of implementing different portability solutions. While in several cases portable implementations perform close to the reference code version, we find that the performance varies significantly depending on the details of the implementation. Achieving optimal performance is not easy, even for relatively simple applications such as the test codes considered in this work. Several factors can affect the performance, such as the choice of the memory layout, the memory pinning strategy, and the compiler used. The compilers and tools are being actively developed, so future developments may be critical for their deployment in HEP experiments.
Frequency distribution of different joint slopes containing ceramic soil under seismic wave action
Authors: Wei Zhengqi , Li Xuanzhe , Cao Haiqing , Wu Tingyao
Published: October 2024

The dynamic response characteristics of high and steep slopes under the action of earthquakes and blasting was focused on, especially the frequency distribution and propagation laws, which are crucial for slope stability assessment. Using stress wave theory as the theoretical basis and advanced FLAC3D numerical simulation technology, we systematically analyze the frequency response of slope under different joint conditions under seismic waves. The nonlinear characteristics of reflected P-wave coefficient and the significant sensitivity of joint to incident wave frequency are revealed when the Angle of incident P-wave changes. The results show that with the increase of the incidence Angle of the incident P-wave, the reflection coefficient of the reflected P-wave decreases slowly at first and then increases sharply to 1.0. The reflection coefficient of the wave at the joint is more sensitive to the frequency of the incident wave. In a biplanar rock mass, multiple reflections of waves between structural planes produce transmitted waves with different time differences.
Relationships between self-efficacy and learning approaches as perceived by computer science students
Authors: Laitinen Satu , Christopoulos Athanasios , Laitinen Petteri , Nieminen Valtteri
Published: October 2024

Optimizing learning outcomes in university students necessitates an understanding of the processes that drive high-quality learning outcomes. This study investigates the motivational factors and learning methodologies perceived by computer science students during an introductory course. A cross-sectional study was conducted with 171 computer science students asked to complete a psychometric instrument (“Study Skills Inventory for Students”) during the first year of their university studies. Two major theoretical frameworks in educational psychology, namely students’ self-efficacy and learning approaches were tested relative to a factor structure obtained from learning situations. The findings supported self-efficacy and three learning approaches among computer science students. Models for deep, surface, and strategic learning approaches suggest that students with higher self-efficacy tend to adopt a deeper approach to learning. Conversely, students with lower self-efficacy were more inclined toward surface learning methods. Furthermore, a link was identified between strategic learning approaches and students’ experiences within their learning environments. The results substantiate earlier research and align with learning approach theories. The findings indicated that, in higher education settings, focus should be directed toward understanding the motivational factors influencing students and their learning approaches for educational outcomes.
Evaluating vision-capable chatbots in interpreting kinematics graphs: a comparative study of free and subscription-based models
Authors: Polverini Giulia , Gregorcic Bor
Published: October 2024

This study investigates the performance of eight large multimodal model (LMM)-based chatbots on the Test of Understanding Graphs in Kinematics (TUG-K), a research-based concept inventory. Graphs are a widely used representation in STEM and medical fields, making them a relevant topic for exploring LMM-based chatbots’ visual interpretation abilities. We evaluated both freely available chatbots (Gemini 1.0 Pro, Claude 3 Sonnet, Microsoft Copilot, and ChatGPT-4o) and subscription-based ones (Gemini 1.0 Ultra, Gemini 1.5 Pro API, Claude 3 Opus, and ChatGPT-4). We found that OpenAI’s chatbots outperform all the others, with ChatGPT-4o showing the overall best performance. Contrary to expectations, we found no notable differences in the overall performance between freely available and subscription-based versions of Gemini and Claude 3 chatbots, with the exception of Gemini 1.5 Pro, available via API. In addition, we found that tasks relying more heavily on linguistic input were generally easier for chatbots than those requiring visual interpretation. The study provides a basis for considerations of LMM-based chatbot applications in STEM and medical education, and suggests directions for future research.
Attitudes toward mathematics and virtual teaching of students in the context of COVID-19: validation and reliability of instruments
Authors: Schmitt-Cerna Isis , Ramírez-Olascuaga Maritza , Arhuis-Inca Wendy , Ipanaqué-Zapata Miguel , Arhuis-Inca Sarai Raquel , Bazalar-Palacios Janina
Published: October 2024

Background

There are few instruments to assess attitudes toward mathematics and virtual teaching; Likewise, there are methodological limitations to study this phenomenon in high school students. The present study aims to evaluate the psychometric properties of the instruments of attitudes toward mathematics and the perception of virtual teaching during COVID-19 in high school students in Peru.

Methods

A total of 400 students participated. The research utilized exploratory and confirmatory factor analyses to evaluate the attitudes mathematics and the perception of virtual teaching instruments’ structure, and assessed reliability through Cronbach’s Alpha (α), Ordinal Alpha (ordinal α), and Omega (Ω) indicators.

Results

Exploratory factor analysis showed that Model 2, with factor loadings above 0.40, was the most suitable for both instruments. This model demonstrated acceptable fit indices (CFI and TLI > 0.90; RMSEA and SRMR <0.08) and internal consistency (α, ordinal α, and Ω > 0.60). Furthermore, confirmatory factor analysis validated a five-dimensional structure for attitudes toward mathematics and a six-dimensional structure for perceptions of virtual teaching.

Conclusion

Both instruments are valid and reliable for assessing these attitudes and perceptions within the context of virtual education during the COVID-19 pandemic. Strengthening mathematical skills through targeted research and interventions is essential to addressing pandemic-induced gaps.
Comparing silicon mineral species of different crystallinity using Fourier transform infrared spectroscopy
Authors: Ellerbrock Ruth H. , Stein Mathias , Schaller Jörg
Published: October 2024

In soils, various solid silica (Si) species exhibit different weathering behaviors and surface reactivities, which are among other characteristics related to the crystallinity of the silicate tetrahedral network. Amorphous species exhibit faster weathering and generally possess a larger specific surface area in comparison to crystalline species. However, the characterization of these different species is commonly based on wet chemical extraction methods, which lack selectivity. While Fourier transform infrared spectroscopy (FTIR) in the mid-infrared range can differentiate between short-range ordered aluminosilicates (SROAS) and pure amorphous silica (ASi), few systematic studies are found on the IR spectral features that distinguish solid Si species by crystallinity. This study aims to identify FTIR absorption bands that can differentiate Si species based on their crystallinity. Our data clearly indicate that ASi can be distinguished from very crystalline silica (quartz) and sea sand. The absorption band at approximately 800 cm−1 in the FTIR spectra allows determining the degree of crystallinity of the studied ASi species since the band becomes smaller and the band maximum shifted toward lower wavenumbers with increasing degree of crystallinity. Hence, FTIR spectra may be used to differentiate certain Si species in complex samples like soils, allowing the estimation of weatherability and surface reactivity of those species.
Adsorption characteristics of As(III) by schwertmannite: new findings in mineral-phase transformation and microbial effects
Authors: Li Hao , Song Wenjie , Li Zhichao , Wang Wei , He Jiang , Lü Changwei
Published: October 2024

The amount of As(III) adsorbed and the interfacial process are closely associated with the phase transformation of Schwertmannite (SCH). At present, studies on the adsorption characteristics of As(III) on SCH and the accompanying phase transformation process, especially the related mechanisms under the mediation of iron-reducing bacteria (FeRB) and sulfate-reducing bacteria (SRB), are limited in existing literature. With the help of continuous characterization, the adsorption behavior of As(III) on SCH was explored, as well as the transformation processes of SCH during these processes. The findings revealed that the SCH, synthesized by the KMnO4 oxidation and ethanol modification methods, exhibited excellent physical adsorption capacity for As(III) due to their increasing specific surface area and porosity. At room temperature (20°C), the saturation adsorption capacities of As(III) by M-SCH and Y-SCH reached 62.69 and 58.62 mg/g, respectively. Moreover, the generation and phase transformation of As(III)-bearing ferrihydrite were observed within a 60-min timeframe. It is the first time this phenomenon has been observed in such a short time, which is presumed to be an intermediate stage in the transformation of SCH into goethite. Furthermore, both FeRB and SRB could enhance the adsorption capacity of SCH for As(III). Comparatively, SRB has a more substantial impact on SCH’s phase transformation. These insights are valuable for the practical application of SCH in treating As(III) pollution.
Prognostic value of neutrophil-to-lymphocyte ratio in patients with non–muscle-invasive bladder cancer with intravesical Bacillus Calmette–Guérin immunotherapy: a systematic review and meta-analysis
Authors: Huang Jiaguo , Lin Li , Mao Dikai , Hua Runmiao , Guan Feifei
Published: October 2024

Background

The predictive accuracy of the preoperative neutrophil-to-lymphocyte ratio (NLR) on the prognosis of patients with non-muscle-invasive bladder cancer (NMIBC) with intravesical Bacillus Calmette–Guérin immunotherapy (BCG) after transurethral resection of the bladder tumor (TURBT) remains unknown. Therefore, the current study performed a systematic review and meta-analysis to examine the relationship between preoperative NLR and the prognosis of patients with NMIBC with intravesical BCG immunotherapy.

Methods

For this systematic review and meta-analysis, articles were retrieved from PubMed, Cochrane Library, Web of Science, and Embase databases from their inception to 14 May 2024. The role of NLR in predicting recurrence and progression in NMIBC was determined using pooled hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Seven articles were included in this meta-analysis, involving 4,187 patients. An elevated NLR was significantly associated with recurrence (HR = 2.67, 95% CI = 1.34–5.32, P < 0.001) and progression (HR = 1.72, 95% CI = 1.13–2.60, P = 0.004) in patients with NMIBC with intravesical BCG immunotherapy.

Conclusion

This meta-analysis demonstrated that elevated preoperative NLR levels were significantly associated with recurrence and disease progression in patients with NMIBC who underwent intravesical BCG immunotherapy after TURBT.

Systematic review registration

https://inplasy.com/inplasy-2024-7-0058/, identifier 202470058.
Glass transition temperature of asphalt binder based on atomistic scale simulation
Authors: Fang Yongwei , Pang Yingying , Zhang Jiandong , Nie Yihan , Lu Hongquan
Published: October 2024

Glass transition is one of the most crucial physical properties for polymerical materials. As a typical complex polymerical material, the glass transition phenomenon in asphalt binder is directly related to their temperature-related properties. To investigate the glass transition characteristics, this study delves into the glass transition temperature of asphalt binder based on molecular dynamics simulations. It is found that the calculation range for the glass transition temperature sits between 100 and 400 K. The evolution of asphalt binder structure is influenced by different cooling rates, where lower cooling rates allow sufficient microstructural rearrangement, resulting in a smaller volume at the lower temperature. Model size is closely associated with the glass transition region. As the size increases, the transition region significantly expands. Increasing the model size also reduces volume fluctuations after isothermal relaxation, providing more stable volume changes. It is observed that higher cooling rates with a model size over 100 Å can well reproduce the glass transition process of asphalt binders. This work provides atomic-scale insights for the glass transition phenomenon in asphalt binder, which could be beneficial for the design of high-performance asphalt binder.
Superior outcome of labial mucosal autograft over limbal allograft in the management of recurrent pterygium with symblepharon: a case report
Authors: Oh Joo Youn , Khwarg Sang In
Published: October 2024

A 40-year-old woman visited our clinic for recurred pterygium and symblepharon in the right eye. She had a history of pterygium excision 8 years before. Over the course of 7 years, we performed pterygium excision combined initially with mitomycin C (MMC) application and conjunctival autograft. This was followed by three procedures using limbal allografts, MMC application, and amniotic membrane transplantation. All procedures were unsuccessful, resulting in aggressive recurrences of pterygial mass and symblepharon, extraocular movement limitation, corneal astigmatism, and decreased visual acuity. Ultimately, we applied a labial mucosal autograft after the recession of pterygial tissue. No complications were observed. Two and a half years postoperatively, the labial mucosal autograft was well-integrated into the conjunctival surface without symblepharon recurrence or abduction limitation. Corneal clarity was restored, and astigmatism was reduced, with no recurrence of pterygium. In conclusion, a labial mucosal autograft is a viable treatment option in complex cases of recalcitrantly recurrent pterygium with symblepharon.
Correlation between obstructive sleep apnea and weight-adjusted-waist index: a cross-sectional study
Authors: Zhang Mengye , Weng Xiaolu , Xu Jing , Xu Xue
Published: October 2024

Background

Obesity is recognized as a prominent factor in the pathogenesis of obstructive sleep apnea (OSA). The weight-adjusted-waist index (WWI) has emerged as a novel metric for assessing adiposity. The study aimed to investigate the potential correlation between WWI and OSA.

Methods

In this study, a cross-sectional analysis was conducted on the data from the National Health and Nutrition Examination Survey (NHANES) during the period from 2013 to 2020. To examine the correlation between WWI and OSA, multivariate logistic regression, smooth curve fitting, subgroup analysis and receiver operating characteristic (ROC) curve were employed.

Results

Among the total 18,080 participants, 9,050 were categorized as having OSA. It was observed that as the quartile range of WWI increased, there was a gradual rise in the prevalence of OSA (37.4% vs. 50.3% vs. 55.1% vs. 57.5%, p < 0.001). Logistic regression analyses demonstrated a significant positive correlation between WWI and the risk of OSA, even after accounting for potential confounders (OR = 1.314, 95% = 1.223, 1.411). Subgroup analysis further revealed a stronger correlation between OSA and WWI among individuals with normal weight, those under 50 years old, and those engaging in moderate physical activities. Smooth curve fitting identified a positive non-linear correlation, with an inflection point at 11.678. ROC analysis indicated that WWI (AUC = 0.664) can serve as a more robust predictor for OSA compared to BMI and waist circumference.

Conclusion

This study provides evidence that elevated levels of WWI are correlated with an increased risk of OSA, indicating the potential utility as predictive indicators for OSA.
Carbon and energy metabolism for the mixotrophic culture of Chlorella vulgaris using sodium acetate as a carbon source
Authors: Yan Xi , Shan Shengzhou , Li Xiaohui , Xu Qingshan , Yan Xiaojun , Ruan Roger , Cheng Pengfei
Published: October 2024

There has been an emergence of a diversity of microalgal mixotrophic synergistic mechanisms due to substrate differences. In this study, the effects of the mixotrophic culture of Chlorella vulgaris were examined. The maximum values of cell density, specific growth rate, and cell dry weight of Chlorella vulgaris were 3.52*107 cells/mL, 0.75 d−1, and 3.48 g/L in the mixotrophic mode, respectively. These were higher than the corresponding values of photoautotrophic or heterotrophic modes. Moreover, it was found that the concentrations of sodium bicarbonate consumed by the Chlorella vulgaris under mixotrophic and photoautotrophic modes were 635 mg/L/d and 505 mg/L/d, respectively; the concentrations of sodium acetate consumed by the Chlorella vulgaris under mixotrophic and heterotrophic modes were 614 mg/L/d and 645 mg/L/d, respectively. The activity of Rubisco was 9.36 U/mL in the mixotrophic culture, which was 3.09 and 4.85 times higher than that of the photoautotrophic and heterotrophic modes, respectively. This indicated that the differences for the carbon source absorption efficiency of Chlorella vulgaris in the mixotrophy led to different internal metabolic efficiencies when compared to photoautotroph or heterotrophy. Additionally, Chlorella vulgaris exhibits a more rapid energy metabolism efficiency when operating in the mixotrophic mode.
Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study
Authors: Fu Chengwei , Hou Xiaoyan , Zheng Chunye , Zhang Yue , Gao Zhijie , Yan Zhaoxian , Ye Yongsong , Liu Bo
Published: October 2024

Background

Previous studies have evaluated the safety and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for the treatment of Parkinson’s disease (PD). However, the mechanism underlying the effect of taVNS on PD remains to be elucidated. This study aimed to investigate the immediate effects of taVNS in PD patients.

Methods

This crossover self-controlled study included 50 PD patients. Each patient underwent three sessions of resting-state functional magnetic resonance imaging (rs-fMRI) under three conditions: real taVNS, sham taVNS, and no taVNS intervention. We analyzed whole-brain amplitude of low-frequency fluctuations (ALFF) from preprocessed fMRI data across different intervention conditions. ALFF values in altered brain regions were correlated with clinical symptoms in PD patients.

Results

Forty-seven participants completed the study and were included in the final analysis. Real taVNS was associated with a widespread decrease in ALFF in the right hemisphere, including the superior parietal lobule, precentral gyrus, postcentral gyrus, middle occipital gyrus, and cuneus (voxel p < 0.001, GRF corrected). The ALFF value in the right superior parietal lobule during real taVNS was negatively correlated with the Unified Parkinson’s Disease Rating Scale Part III (r = −0.417, p = 0.004, Bonferroni corrected).

Conclusion

TaVNS could immediately modulate the functional activity of brain regions involved in superior parietal lobule, precentral gyrus, postcentral gyrus, middle occipital gyrus, and cuneus. These findings offer preliminary insights into the mechanism of taVNS in treating PD and bolster confidence in its long-term therapeutic potential. TaVNS appears to reduce ALFF values in specific brain regions, suggesting a potential modulation mechanism for treating PD.
Unraveling the interplay of kinesin-1, tau, and microtubules in neurodegeneration associated with Alzheimer’s disease
Authors: Durairajan Siva Sundara Kumar , Selvarasu Karthikeyan , Singh Abhay Kumar , Patnaik Supriti , Iyaswamy Ashok , Jaiswal Yogini , Williams Leonard L. , Huang Jian-Dong
Published: October 2024

Alzheimer’s disease (AD) is marked by the gradual and age-related deterioration of nerve cells in the central nervous system. The histopathological features observed in the brain affected by AD are the aberrant buildup of extracellular and intracellular amyloid-β and the formation of neurofibrillary tangles consisting of hyperphosphorylated tau protein. Axonal transport is a fundamental process for cargo movement along axons and relies on molecular motors like kinesins and dyneins. Kinesin’s responsibility for transporting crucial cargo within neurons implicates its dysfunction in the impaired axonal transport observed in AD. Impaired axonal transport and dysfunction of molecular motor proteins, along with dysregulated signaling pathways, contribute significantly to synaptic impairment and cognitive decline in AD. Dysregulation in tau, a microtubule-associated protein, emerges as a central player, destabilizing microtubules and disrupting the transport of kinesin-1. Kinesin-1 superfamily members, including kinesin family members 5A, 5B, and 5C, and the kinesin light chain, are intricately linked to AD pathology. However, inconsistencies in the abundance of kinesin family members in AD patients underline the necessity for further exploration into the mechanistic impact of these motor proteins on neurodegeneration and axonal transport disruptions across a spectrum of neurological conditions. This review underscores the significance of kinesin-1’s anterograde transport in AD. It emphasizes the need for investigations into the underlying mechanisms of the impact of motor protein across various neurological conditions. Despite current limitations in scientific literature, our study advocates for targeting kinesin and autophagy dysfunctions as promising avenues for novel therapeutic interventions and diagnostics in AD.
Improvements in upper extremity isometric muscle strength, dexterity, and self-care independence during the sub-acute phase of stroke recovery: an observational study on the effects of intensive comprehensive rehabilitation
Authors: K. Řasová , P. Martinková , M. Vařejková , B. Miznerova , J. Hlinovská , D. Hlinovský , D. Iskendri , L. Lebdušková , R. Vojíková , J. Zakouřilová , J. Běhounek , V. Musil , T. Philipp
Published: October 2024

Background

Stroke often impairs upper extremity motor function, with recovery in the sub-acute phase being crucial for regaining independence. This study examines changes in isometric muscle strength, dexterity, and self-care independence during this period, and evaluates the effects of a comprehensive intensive rehabilitation (COMIRESTROKE).

Methods

Individuals in sub-acute stroke recovery and age- and sex-matched controls were assessed for pre- and post-rehabilitation differences in primary outcomes (grip/pinch strength, Nine Hole Peg Test [NHPT], Action Research Arm Test [ARAT]). COMIRESTROKE’s effects on primary and secondary outcomes (National Institute of Health Stroke Scale [NIHSS], Modified Rankin Scale [MRS], Functional Independence Measure [FIM]) were evaluated. Outcomes were analyzed for dominant and non-dominant limbs, both regardless of impairment and with a focus on impaired limbs.

Results

Fifty-two individuals with stroke (NIHSS 7.51 ± 5.71, age 70.25 ± 12.66 years, 21.36 ± 12.06 days post-stroke) and forty-six controls participated. At baseline, individuals with stroke showed significantly lower strength (dominant grip, key pinch, tip-tip pinch, padj < 0.05), higher NHPT scores (padj < 0.05), and lower ARAT scores (padj < 0.001). COMIRESTROKE led to improvements in dominant key pinch, non-dominant tip-tip pinch, NHPT, and both dominant and non-dominant ARAT (padj < 0.05). Notably, non-dominant key pinch improved significantly when considering only impaired hands. Pre- and post-test differences between groups were significant only for ARAT (both limbs), even after adjustment (padj < 0.05). All secondary outcomes (NIHSS, MRS, FIM) showed significant improvement post-COMIRESTROKE (padj < 0.001).

Conclusion

Individuals with stroke exhibit reduced muscle strength and dexterity, impairing independence. However, comprehensive intensive rehabilitation significantly improves these functions. Data are available from the corresponding author upon request and are part of a sub-study of NCT05323916.
Liquid–liquid phase separation and conformational strains of α-Synuclein: implications for Parkinson’s disease pathogenesis
Authors: Ruiz-Ortega Eva D. , Wilkaniec Anna , Adamczyk Agata
Published: October 2024

Parkinson’s disease (PD) and other synucleinopathies are characterized by the aggregation and deposition of alpha-synuclein (α-syn) in brain cells, forming insoluble inclusions such as Lewy bodies (LBs) and Lewy neurites (LNs). The aggregation of α-syn is a complex process involving the structural conversion from its native random coil to well-defined secondary structures rich in β-sheets, forming amyloid-like fibrils. Evidence suggests that intermediate species of α-syn aggregates formed during this conversion are responsible for cell death. However, the molecular events involved in α-syn aggregation and its relationship with disease onset and progression remain not fully elucidated. Additionally, the clinical and pathological heterogeneity observed in various synucleinopathies has been highlighted. Liquid–liquid phase separation (LLPS) and condensate formation have been proposed as alternative mechanisms that could underpin α-syn pathology and contribute to the heterogeneity seen in synucleinopathies. This review focuses on the role of the cellular environment in α-syn conformational rearrangement, which may lead to pathology and the existence of different α-syn conformational strains with varying toxicity patterns. The discussion will include cellular stress, abnormal LLPS formation, and the potential role of LLPS in α-syn pathology.
Self-perceptual blindness to mental fatigue in mining workers
Authors: Purto Helena , Anabalon Héctor , Vargas Katherine , Jara D Cristian , de la Vega Ricardo
Published: October 2024

Mental fatigue is a psychophysiological state that adversely impacts performance in cognitive tasks, increasing risk of occupational hazards. Given its manifestation as a conscious sensation, it is often measured through subjective self-report. However, subjective measures are not always true measurements of objective fatigue. In this study, we investigated the relationship between objective and subjective fatigue measurements with the preventive AccessPoint fatigue assay in Chilean mine workers. Subjective fatigue was measured through the Samn-Perelli scale, objective fatigue through a neurocognitive reaction time task. We found that objective and subjective fatigue do not correlate (−0.03 correlation coefficient, p < 0.001). Moreover, severe fatigue cases often displayed absence of subjective fatigue coupled with worse cognitive performance, a phenomenon we denominated Perceptual Blindness to fatigue. These findings highlight the need for objective fatigue measurements, particularly in high-risk occupational settings such as mining. Our results open new avenues for researching mechanisms underlying fatigue perception and its implications for occupational health and safety.
Determinants of cervical cancer screening uptake among reproductive-age women in southwest Ethiopia: a case-control study
Authors: Yosef Tewodros , Birhanu Bitewlgn , Shifera Nigusie , Bekele Bayu Begashaw , Asefa Adane
Published: October 2024

Background

Cervical cancer is a major global health issue, with 604,000 diagnoses and 342,000 deaths in 2020. Despite the importance of early detection, only 5% of eligible women in Ethiopia are screened. Therefore, this study aimed to assess the determinants of cervical cancer screening uptake among reproductive-age women at selected public hospitals in southwest Ethiopia.

Methods

A case-control study involving 392 women (98 cases and 294 controls) aged 15-49 was conducted across three hospitals. Cases were women aged 15 to 49 who had cervical cancer screening, while controls were reproductive-age women seeking antenatal care or family planning but not screened. Data were collected via face-to-face interviews with pretested questionnaires and analyzed using SPSS 25. Bivariate analysis identified candidate variables with P-values < 0.25, and a multivariable logistic regression model determined factors with P-values < 0.05 as significant for cervical cancer screening uptake.

Results

Determinants of cervical cancer screening uptake included high knowledge of screening (AOR=6.23; 95%CI: 1.96, 19.79), a positive attitude toward screening (AOR=6.12; 95%CI: 2.40, 15.58), women aged 30-39 (AOR=3.94; 95%CI: 1.79, 8.63) and 40-49 (AOR=3.54; 95%CI: 1.52, 8.22), and those who reached health facilities within 60 minutes (AOR=2.32; 95%CI: 1.21, 4.45).

Conclusion

The study pinpointed age, knowledge, attitude toward cervical cancer screening, and accessibility to health facilities within a 60-minute radius as pivotal factors impacting cervical cancer screening uptake among reproductive-age women. These findings highlight the importance of targeted education, promoting positive attitudes, and enhancing healthcare accessibility to improve screening uptake and reduce the burden of cervical cancer.
Nipple adenoma detected by multimodal ultrasound: a case report and literature review
Authors: Lu Jianghao , Zhang Jingwen , Wu Tingting , Ma Yuqin , Zhou Peng
Published: October 2024

Nipple adenoma (NA) is a rare benign lesion of the lactiferous ducts, often mistaken for malignancy due to its diverse clinical and imaging presentations. We report the case of a 34-year-old female presenting with persistent bloody discharge and nipple erosion, for which multimodal ultrasound evaluation was pivotal in the differential diagnosis. Ultrasonography revealed a hypoechoic, well-defined nodule in the left nipple, with significant blood flow and a fast-in-fast-out contrast enhancement pattern, indicative of NA. Despite the presentation mimicking malignant processes, the benign nature of the lesion was confirmed postoperatively via histology and immunohistochemistry. This case underscores the value of a comprehensive ultrasound approach in diagnosing NA, emphasizing its ability to distinguish it from malignant lesions, and thus infer an appropriate treatment course. Maintaining a high index of suspicion coupled with tailored ultrasound techniques is recommended for accurate NA diagnosis, which remains a challenging yet critical task to avoid unnecessary aggressive interventions.
Infant formula with added Lacticaseibacillus rhamnosus GG supported adequate growth and was well tolerated in healthy term infants: a randomized controlled trial
Authors: Berseth Carol Lynn , Yeiser Michael , Harris Cheryl L. , Kinnaman Jennifer N. , Lappin Victoria , Wampler Jennifer L. , Zhuang Weihong , Vanderhoof Jon
Published: October 2024

Introduction

Lacticaseibacillus rhamnosus GG (LGG) is a well-studied probiotic with a history of safe use.

Methods

In this double-blind, prospective study, growth and tolerance were evaluated in healthy term infants randomized to: marketed, routine intact cow's milk protein-based formula (Control, n = 172) or a similar investigational formula with added LGG (INV-LGG, n = 179; 106 CFU LGG®/g powder) from 14 to 120 days of age. Anthropometrics, stool characteristics, fussiness, and gassiness were evaluated through Day 120. Medically confirmed adverse events were recorded throughout the study period. The primary outcome was rate of weight gain from Day 14–120.

Results

Of 351 infants enrolled, 275 completed (Control, n = 131; INV-LGG, n = 144). No significant group differences in rate of weight gain from Day 14–120 were detected. Study formula acceptance and tolerance was good with no significant differences in study discontinuation due to study formula or parent-reported gassiness, stool frequency, or stool consistency; however mean fussiness relative to normal was significantly lower for INV-LGG vs Control at Days 60 and 90.

Discussion

In healthy term infants, a routine intact cow's milk protein-based formula with added LGG supported adequate growth and was well tolerated. Further studies are needed to evaluate potential benefits for fussiness and efficacy outcomes.

Clinical Trial Registration

Clinicaltrials.gov, identifier (NCT01897922).
Case Report: A delicate equilibrium of exocrine pancreatic recovery and hepatotoxicity with elexacaftor/tezacaftor/ivacaftor therapy in a pediatric patient with cystic fibrosis
Authors: Coughlin Michael P. , Sankararaman Senthilkumar , Roesch Erica A. , Certo Emily D. , Brej Benjamin L. , Konstan Michael W.
Published: October 2024

This case report presents a comprehensive evaluation of the complex balance of therapeutic benefits and potential risks associated with the cystic fibrosis transmembrane conductance regulator (CFTR) modulator elexacaftor/tezacaftor/ivacaftor (ETI) therapy in managing an eight-year-old male with cystic fibrosis (CF) and exocrine pancreatic insufficiency (EPI). While ETI therapy significantly enhanced exocrine pancreatic function, it led to hepatotoxicity, necessitating therapy discontinuation. Attempts to restart ETI at reduced doses were unsuccessful due to persistent hepatic dysfunction. Reduced ETI dosing frequency, implemented due to hepatic dysfunctions, did not result in substantial therapeutic benefits. Clinical markers showed a resurgence of severe EPI and sustained need for gastrostomy tube feeds, with only modest improvement in hepatic function compared to the period following ETI cessation or during prior use of CFTR modulator therapy with lumacaftor/ivacaftor. This case underscores the importance of personalized therapeutic approaches, biomarker-guided monitoring, and multidisciplinary insights to optimize CF management while also highlighting the ongoing need for research to mitigate hepatotoxicity risks and ensure long-term therapeutic efficacy.
Pseudospectra of quasinormal modes and holography
Authors: Areán Daniel , Garcia-Fariña David , Landsteiner Karl
Published: October 2024

The holographic duality (also known as AdS/CFT correspondence or gauge/gravity duality) postulates that strongly coupled quantum field theories can be described in a dual way in asymptotically anti-de Sitter space. One of the cornerstones of this duality is the description of thermal states as black holes with asymptotically anti-de Sitter boundary conditions. This idea has led to valuable insights into fields such as transport theory and relativistic hydrodynamics. In this context, the quasinormal modes of such black holes play a decisive role, and therefore their stability properties are of utmost interest for the holographic duality. We review recent results using the method of pseudospectra.
Optimizing multi-environment trials in the Southern US Rice belt via smart-climate-soil prediction-based models and economic importance
Authors: Prado Melina , Famoso Adam , Guidry Kurt , Fritsche-Neto Roberto
Published: October 2024

Rice breeding programs globally have worked to release increasingly productive and climate-smart cultivars, but the genetic gains have been limited for some reasons. One is the capacity for field phenotyping, which presents elevated costs and an unclear approach to defining the number and allocation of multi-environmental trials (MET). To address this challenge, we used soil information and ten years of historical weather data from the USA rice belt, which was translated into rice response based on the rice cardinal temperatures and crop stages. Next, we eliminated those highly correlated Environmental Covariates (ECs) (>0.95) and applied a supervised algorithm for feature selection using two years of data (2021-22) and 25 genotypes evaluated for grain yield in 18 representative locations in the Southern USA. To test the trials’ optimization, we performed the joint analysis using prediction-based models in four different scenarios: i) considering trials as non-related, ii) including the environmental relationship matrix calculated from ECs, iii) within clusters; iv) sampling one location per cluster. Finally, we weigh the trial’s allocation considering the counties’ economic importance and the environmental group to which they belong. Our findings show that eight ECs explained 58% of grain yield variation across sites and 53% of the observed genotype-by-environment interaction. Moreover, it is possible to reduce 28% the number of locations without significant loss in accuracy. Furthermore, the US Rice belt comprises four clusters, with economic importance varying from 13 to 45%. These results will help us better allocate trials in advance and reduce costs without penalizing accuracy.
Ethnic origin of Israeli Jews and psychological responses to the extreme stress of the ongoing war with Hamas in Gaza
Authors: Eshel Yohanan , Kimhi Shaul , Marciano Hadas , Adini Bruria
Published: October 2024

Introduction

Discrimination constitutes a source of stress for minority groups, leading to heightened levels of depression. Discrimination can also elicit positive responses aimed at reducing detrimental impacts. The stress experienced by minority groups may impact their mindset and influence their negative emotional responses. Israeli Jewish society comprised for many years two large communities: the dominant Ashkenazi people, who emigrated from East Europe, and the Mizrahi discriminated minority whose members came from Muslim countries. The Mizrahi minority has become a mainstream community over time, and its size equals the Ashkenazi group. This change raises an interesting issue that has not been investigated empirically: What characterizes the psychological responses to the stress of a formerly discriminated minority?

Methods

Two representative samples responded to a similar questionnaire measuring inhibiting and bolstering coping strategies. The first sample of 930 people participated in this structured survey between October 12 and 19, 2022. No external adversity threatened Israel at that time. The second sample of 1,608 Israeli Jews participated between October 11 and 17, 2023, a few days after Hamas attacked the southern region of Israel, killed more than a 1,000 people, and kidnapped 100. We examine the impact of moderate and extreme stress of war on the maladaptive levels of anxiety and depression. Furthermore, we investigated the shielding psychological coping measures of this former minority, as compared to Ashkenazi group’s response.

Results

Results show that the formerly minority Mizrahi group expresses higher levels of depression, anxiety, and sense of danger under extreme stress compared to the Ashkenazi group. Mizrahi individuals compensated concurrently for these negative emotions by fostering enhanced hope and societal resilience compared to the other group.

Discussion

The main contributions of the present study are (a) Demonstration that psychological responses of descendants of a minority group to highly stressful conditions do not necessarily agree with their current status as a mainstream community. (b) Indicating that the phenomenon of concurrently enhanced negative and positive responses in face of extreme stress is associated with ethnic origin and history. (c) Associating the effects of different socio-demographic variables with the psychological response of the investigated groups to extreme and moderate stress.
Cultural hybridity and body image formation: exploring the experiences of Wushu male practitioners at the Siberian Chinese Martial Arts Center
Authors: Santanna Ekaterina A. , Li Benqian
Published: October 2024

This study explores the formation of a hybrid body image among white cisgender males practicing Wushu at the Siberian Chinese Martial Arts Center. Grounded in Social Identity Theory and the concept of bicultural identity, the research employs narrative interviews with 12 participants. Thematic analysis revealed three main themes: the creation of a hybrid identity blending Chinese martial arts traditions with Russian cultural backgrounds, conceptualized as judanren; the challenges associated with this identity in both Russian and Chinese contexts; and the role of Wushu uniforms in reconciling these cultural contradictions, serving as a “second skin” for practitioners. The findings contribute to a more inclusive understanding of body image and identity formation in a multicultural, non-Western context.
Body, image, and digital technology in adolescence and contemporary youth culture
Authors: Demaria Francesco , Pontillo Maria , Di Vincenzo Cristina , Bellantoni Domenica , Pretelli Italo , Vicari Stefano
Published: October 2024

The physical, psychological and social changes that occur during adolescence constitute a physiological crisis that is necessary for development and growth. The establishment of a suitable “self-image” is important for facilitating harmonious psychophysical development during this time. In the current era, digital technology (DT) serves as an extraordinary means of communication for young people, who make significant use of images as a mode of expression. Accordingly, there is growing interest in the relationship between physical development, self-image and use of DT. A review of the published literature on the topic was carried out in April 2024. Fourteen studies (n = 14) were inclused from search of electronic databases such as PubMed, CINAHL, PsycInfo, MedLine, and Cochrane Library. The aim of this study is to explore the influence of (DT) on cultural models of adolescent body image, and how this “social” culture can affect wellbeing and development. It was considered that the rise of DT and social media (SM) emphasized in young people the culture of appearance, adherence to ideal models (thinness ideal) and social comparison at an unprecedented level. It was estimated that the digital mechanism works on the adolescent’s vulnerability and stimulates the desire for experimentation and amplifies cultural beliefs that expose the young to deviant or pathological behaviors on the body. The use of digital images emphasizes the perception of self by making it more real and alive but empty of content. Our framework highlights that the adolescent can defend himself if he leaves the homologation that the SM condition, regains his own experiences, fill with emotional content and real life the images and the representation of the body.
Validation of the CRAVE-C scale in Chinese adults: a four-study examination of competing motivations for physical activity versus rest
Authors: Cheng Zhihui , Taylor Alyx , Stults-Kolehmainen Matthew A. , Gerber Markus , Herold Fabian , Ross Michael , Ash Garrett , Kramer Arthur F. , Zhao Mengxian
Published: October 2024

Background

The study aimed to validate the Cravings for Rest and Volitional Energy Expenditure (CRAVE) scale among Chinese adults with different health conditions (healthy control, chronic illnesses, and psychiatric disorders) and skill levels (athletes vs. non-athletes).

Methods

In Study 1, a confirmatory factor analysis (CFA) using the Maximum Likelihood Method (MLM) was performed on a Chinese sample of emerging adults (N = 481) to evaluate the structural validity of the Cravings for Rest and Volitional Energy Expenditure-Chinese version (CRAVE-C). In Study 2, differences in “Move” and “Rest” desires were examined among patients with psychiatric disorders, patients with chronic illnesses, and healthy controls. In study 3, investigated the relationship between cardiorespiratory fitness and exercise motivation using the CRAVE-C (N = 83). In Study 4, the changes in “Move” desire from baseline to post-training were compared between athletes and non-athletes.

Results

Results from Study 1 indicated that the 10-item CRAVE-C showed good fit indices (Chi2 (34) = 118.769, CFI = 0.95, TLI = 0.934, SRMR = 0.053, RMSEA = 0.072). “Move” positively correlated with various factors of the Affective Exercise Experiences Questionnaire-Chinese and the Physical Effort Scale-Chinese, while “Rest” correlated negatively. In Study 2, Patients with psychiatric disorders had a significantly higher “Move” desire than healthy controls. Patients with chronic illnesses had a significantly higher “Rest” desire than healthy controls. In Study 3, higher cardiorespiratory fitness was associated with a slight increase in “Move” desire (3.26% ± 37.35%) and a decrease in “Rest” desire (18.94% ± 66.99%). Lower fitness was linked to a significant decline in “Move” desire (−54.61% ± 111.33%) and an increase in “Rest” desire (43.62% ± 63.64%). In Study 4, the athlete group demonstrated a significant increase in “Move” desire from baseline to post-training, whereas the non-athlete group reported a significant decrease in “Move” desire from baseline to post-training.

Conclusion

The 10-item CRAVE-C has good reliability and validity in the Chinese cultural context and can be used among Chinese adults with different health conditions and skill levels.
Research hot topics and frontiers in social anxiety over the past decade: a CiteSpace bibliometric analysis based on Web of Science database from 2013 to 2023
Authors: Zhang Peng , Wang Mingliang , Ding Lin , Zhang Jianing , Yuan Yuqing , Tian Xin
Published: October 2024

Objective

To understand the current study of social anxiety (SA) over the past decade, and to analyze the research hot topics and frontiers in this field.

Methods

CiteSpace 6.2.R3 was used to analyze the literature on SA collected in the Web of Science Core Collection database from 2013 to 2023.

Results

A total of 9940 literature were included after the screening, and the annual publication volume showed a steady increase. The results emphasize that Zvolensky MJ, Pine DS, and Heimberg RG are important authors in the field of SA. The United States has the highest number of publications, with the University of California System contributing the most. Research hotspots include cognitive impairment, risk factors, complications, neuroimaging, and intervention strategies. SA related to the “theory of mind”, “bullying victimization”, “mobile phone”, “network analysis”, “technology”, and “satisfaction” are emerging research foci.

Conclusion

This study identifies the current situation and trends of SA research, and provides a reference for future research topics and directions.