bluuebunny/crossref_metadata_2025 huggingface dataset:
Newborn screening follow-up in Bavaria: height and weight in paediatric patients with congenital adrenal hyperplasia
Authors: Dubinski Ilja , Marzi Carola , Nennstiel Uta , Schiergens Katharina , Schmidt Heinrich , Odenwald Birgit
Published: December 2024

Objectives

Auxology is essential for monitoring congenital adrenal hyperplasia (CAH). Data from prospective studies of newborn screening (NBS) are scarce.

Methods

Analysis of data extracted from a population-based prospective long-term follow-up survey study of children detected through NBS in Bavaria in 1999–2018. The study is based on standardized parent or patient questionnaires, supplemented by medical reports. Height, weight, and treatment data of 146 children/adolescents with classical CAH were analyzed. The entire observation period up to the age of 18 years was completed by 55 patients. Standard Deviation Scores (SDS) for height/body-mass-index (BMI) at different ages and the deviation of the height SDS at age 18 years from the parental target-height SDS were calculated.

Results

Male and female patients with CAH showed different and altered growth patterns, resulting in a median [IQR] SDS deviation from target height of −0.81 [−1.05, −0.41] in males and −0.35 [−0.90, 0.02] in females. BMI-SDS values were significantly (p<0.05) increased in males aged 6–16 years and in females aged 2 and 8–12 years. The average total steroid dose was higher in males (p<0.001). For deviations from target height, significant associations were found with sex (p<0.05) and adherence (p<0.01), but not with mutation group or steroid-dose. For BMI, none of the parameters showed a significant correlation.

Conclusions

Early treatment after NBS has helped to improve, but not to normalize, the development of height and weight in patients with CAH. Optimizing monitoring and treatment, preferably sex-specific, remains a challenge for clinical practice and research.
Does clonidine stimulate copeptin in children?
Authors: Binder Gerhard , Weber Karin , Peter Andreas , Schweizer Roland
Published: December 2024

Objectives

Copeptin is secreted in isomolar amounts along with AVP. Its stability makes it a perfect biomarker of AVP deficiency. In children, dynamic GH tests were shown to stimulate copeptin. Here, we retrospectively studied the effect of clonidine on copeptin release.

Methods

This is a monocentric retrospective analysis of donated residual serum samples from 42 children with suspected growth hormone deficiency (GHD) who underwent clonidine stimulation between 2020 and 2023. Copeptin was measured in baseline, 30-, 60-, 90- and 120-min samples by BRAHMS Copeptin proAVP Kryptor immunofluorescence assay.

Results

There were 20 patients with GHD and 22 without; no patient had polyuria-polydipsia syndrome. Median age was 6.7 years (quartiles; 5.6–7.8), and the median height was −2.92 SDS (−3.42 to −2.34). The median baseline level of copeptin was 5.6 pmol/L (3.4–9.6). Median copeptin mildly decreased to 4.5 pmol/L (3.0–10.0) after 30 min; this change was not significant (p=0.45). Thereafter, median values remained low at 4.6, 4.6, and 4.6 pmol/L (60, 90, and 120 min). There was no correlation between baseline copeptin levels and the diagnosis of GHD.

Conclusions

The clonidine stimulation test does not stimulate copeptin release and is not suitable for the assessment of AVP deficiency in children.
Unclear symptoms, early diagnosis and perfect outcome: a case diagnosed as sepiapterin reductase deficiency hidden behind vitamin B12 deficiency
Authors: Akbeyaz İsmail Hakkı , Ünver Olcay , Öztürk Gülten , Hişmi Burcu Öztürk , Ayaz Akif , Aydın Kürşad , Türkdoğan Dilşad
Published: December 2024

Objectives

Sepiapterin reductase deficiency (SRD) is a rare dopa-sensitive neurotransmitter disorder caused by autosomal recessive mutations in the sepiapterin reductase gene. The triad of paroxysmal stiffening, oculogyric crises, and hypotonia are highly suggestive in some patients. However, in other patients, the clinical picture may be nonspecific and remain under-recognized and misdiagnosed as cerebral palsy.

Case presentation

We present a nine-month-old boy who initially presented with hypotonia and developmental delay, diagnosed as vitamin B12 deficiency. Upon he did not respond to vitamin replacement treatment, he was diagnosed with SRD by whole-exome sequencing (WES). The boy improved dramatically under treatment with L-dopa, 5-hydroxytryptophan and BH4.

Conclusions

We aim to emphasize that SRD can present with nonspecific symptoms, leading to a diagnostic delay for this rare but treatable disease. Moreover, our case is the first to demonstrate the clinical benefit of BH4 add-on treatment. Early intervention is crucial for good outcome and neurodevelopment.
Closed form formulae for two interacting equal parallel through-wall cracks embedded in an infinite elastic medium under normal tension
Authors: Gilles Philippe , Chapuliot Stephane
Published: December 2024

Fitness-For-Service (FFS) and regulatory codes provide rules allowing determining whether multiple flaws shall be combined into a single flaw or evaluated separately. However, these rules set thresholds beyond which flaws are replaced by an envelope sometimes over conservative. The present study aims to develop a hybrid surrogate model accounting for crack interaction in an infinite isotropic homogeneous medium subjected to a uniform stress field normal to the reference plane. The paper presents closed form formulae for interaction factors relative to parallel equal through-wall cracks subjected to normal tension. Crack shielding is analysed in detail: the equation of the shielding limit is established and mode I and mode II variations of overlapped cracks are compared. Comparison with Finite Element calculations for all configurations validate the results.
Radiologia forense e antropologia: a união de duas modalidades essenciais nas investigações médicas legais
Authors: Vergara Clayton Sidney de Almeida
Published: December 2024

A antropologia forense e a radiologia forense desempenham papeis complementares e essenciais nas investigações criminais e na identificação de restos mortais. A antropologia forense, com suas raízes históricas na anatomia europeia e desenvolvimento na América, utiliza técnicas osteológicas para determinar características individuais como idade, sexo, ancestralidade e estatura dos restos mortais, além de estimar o tempo desde a morte e reconstruir eventos traumáticos. Em contraste, a radiologia forense emprega métodos de imagem, como radiografias, tomografias computadorizadas e ressonância magnética, para identificar lesões ósseas e teciduais que não são visíveis externamente, contribuindo para a análise de traumas, determinação da causa da morte e identificação de vítimas desconhecidas.A colaboração interdisciplinar entre antropólogos e profissionais das técnicas radiológicas é crucial para uma análise abrangente e precisa dos restos mortais. Questões éticas, como privacidade e consentimento informado, são importantes ao utilizar dados médicos e imagens em investigações forenses. Avanços tecnológicos, como a reconstrução facial tridimensional e a antropologia virtual, têm melhorado a eficácia e precisão das análises forenses, oferecendo novas ferramentas para a identificação e análise de vítimas. A pesquisa contínua e o desenvolvimento de novas técnicas são fundamentais para aprimorar as práticas forenses.Este artigo explora a interseção entre antropologia forense e radiologia forense, destacando a importância da colaboração interdisciplinar, abordando questões éticas e examinando os avanços tecnológicos recentes. Também identifica lacunas na pesquisa atual e sugere direções para futuras investigações que possam aprimorar as técnicas e abordagens forenses, ressaltando o impacto significativo da tecnologia na evolução das práticas forenses.
The Role of BPIP in Indonesia’s Legal Reform: Navigating Social Transformation and Ideology Education Challenges
Authors: Lutfi Fuad , Pramono Suwito Eko , Masrukhi Masrukhi
Published: December 2024

The Agency for Pancasila Ideology Education (BPIP) plays a pivotal role in Indonesia’s ongoing legal reform, acting as a vital institution in promoting Pancasila—the nation’s foundational ideology. This research explores the significance of BPIP in navigating the intricate nexus between legal reform, social transformation, and ideology education. The urgency of this study stems from the pressing need to address challenges posed by globalization, which often undermines Indonesia’s ideological values, and the growing demand for a legal system aligned with Pancasila principles. By employing a socio-legal approach, this study examines BPIP’s functions, legal framework, and effectiveness in fostering ideological integrity while accommodating diverse societal transformations. The novelty of this research lies in its comprehensive analysis of BPIP’s strategic role in aligning legal reforms with Pancasila-based values. It highlights the institution's contribution to addressing ideological fragmentation and its potential to bridge the gap between constitutional ideals and societal realities. Moreover, the study underscores the importance of integrating ideology education with legal reform efforts to ensure sustainability and inclusivity. The findings provide a critical evaluation of BPIP’s impact on Indonesia’s legal development and propose actionable strategies to enhance its role in shaping a transformative and ideology-driven legal framework. This research contributes to the broader discourse on legal reform by offering a unique perspective on the interplay between ideology and law, serving as a reference for policymakers and scholars seeking to strengthen Indonesia’s legal and ideological foundations.
Analyzing the Role of Apparel E-Retailer’s Brand Reputation in Moderating the Influence of Social Media Marketing and Electronic Word of Mouth
Authors: Dewantoro Faishal Zuhair Bimo , Nurdin Sobari
Published: December 2024

This study aims to explore how social media marketing (SMM) and electronic word of mouth (eWOM) influence consumers' online purchase intentions, considering the mediating role of conviction and the moderating role of e-retailer apparel brand reputation. Using a quantitative approach, the study collected primary data through a questionnaire distributed to 300 respondents familiar with the Erigo brand, employing random sampling. Data analysis was conducted using Structural Equation Modeling (SEM) with Smart PLS software. The findings reveal that SMM significantly impacts conviction, while eWOM shows a positive but insignificant effect. Conviction has a positive but insignificant impact on online purchase intention (OPI), though it mediates the effect of SMM on OPI. However, conviction does not significantly mediate the relationship between eWOM and OPI. SMM and eWOM have direct significant effects on OPI, with brand reputation moderating the influence of SMM and eWOM on OPI through conviction. This research offers valuable insights for decision-makers, particularly in leveraging social media marketing and eWOM strategies to optimize business effectiveness and efficiency. Startup companies in the digital industry can benefit from these strategies by considering conviction and brand reputation as critical factors. Limitations include the relatively small respondent pool of 300 and the need for broader population analysis and deeper exploration of blue ocean strategies for startups.
Approximation of functions from Hӧlder class by biharmonic Poisson integrals
Authors: Kharkevych Yu.I. , Shutovskyi A.M.
Published: December 2024

The biharmonic equation in Cartesian coordinates is considered for the case of the upper half-plane. The solution of such a fourth-order partial differential equation for given boundary conditions is represented in the form of an integral of the product of the function and the delta-shaped kernel, which in this paper plays the role of an approximating aggregate. In the paper, we found an exact equality for the upper bound of the deviation of Hölder class functions from the considered biharmonic Poisson operator in the uniform metric.
The unwicked Stepmother: the Dowager Empress Eleonora II Gonzaga as a swing vote at the Court of Vienna
Authors: Höbelt Lothar
Published: December 2024

The Dowager Empress Eleonora II Gonzaga was credited with great influence overher step-son Emperor Leopold I (r. 1657-1705). For that reason, she was not just courted byVenetian, French and Papal diplomats. Unusual for female members of the Casa d’Austria,even the minutes of official meetings of Austrian ministers show that she was a force to bereckoned with. However, Eleonora did not consistently favour one of the court factions. Themarriage of her daughter to Polish king Michal Korybut in 1670 might have been supposed toturn her into an ‘Easterner’, willing to appease the French. Indeed, Eleonora was originallyregarded as an ally by French ambassador Gremonville, but decisively turned against him in1671/72. Ten years later, with a French threat to her native Mantua (and her own inheritanceprospects in Monferrato), she once again spear-headed a drive by the pro-Spanish ‘warhawks’ against the ‘business-as-usual’ appeasers in power at the time.
El trasfondo histórico-artístico de los retratos de Estado de la Reina María Cristina Habsburgo Lorena
Authors: Aparicio Gonzalez Maria Jesus
Published: December 2024

El presente artículo tiene como objetivo principal examinar detalladamente la construcción de la imagen de la reina María Cristina de Habsburgo Lorena, centrándose especialmente en los aspectos esenciales de su trayectoria vital: reina consorte, regente y reina madre.
La hipótesis planteada se ajusta en la indagación sobre si los emblemas áulicos, utilizados durante la Edad Moderna y presentes en la representación pictórica femenina, perduran en doce retratos ceremoniales de doña María Cristina en plena Edad Contemporánea.
Los resultados obtenidos confirman que esta exposición visual de la reina austríaca trasciende la simple representación, al postular un modelo de virtudes encarnado por quien personifica la identidad nacional. Su imagen se erige como un documento histórico-social que aborda el liderazgo de una mujer que, de manera inesperada, guiaría junto a las Cortes durante dieciséis años a España, superando momentos de crisis personales, políticas y las críticas de los detractores de la Restauración.
Diplomacia indirecta por toda Europa: Las misiones de Antonio Rincón and Hieronymus ?aski en la década de1520
Authors: Tamus Elvira
Published: December 2024

La política europea en la década de 1520 estuvo determinada por la competencia Valois-Habsburgo, por el dominio sobre Italia y la rivalidad Habsburgo-otomana en la región de Europa Central y el Mediterráneo. En esta compleja situación, los actores diplomáticos desempeñaron un papel crucial en el proceso de toma de decisiones al recopilar y transmitir información, preparar y formar alianzas, así como brindar diversos servicios para fomentar las relaciones existentes y crear otras nuevas. Sin embargo, esta agencia individual de estos actores está lejos de ser explorada a fondo en la historiografía. Esta contribución analiza las formas en que Antonio Rincón, el enviado español de Francisco I de Francia, y Hieronymus ?aski, el enviado polaco de Juan I de Hungría, establecieron y fomentaron contactos, así como recopilaron información para sentar las bases de una coalición contra los Habsburgo. Este enfoque centrado en los actores pretende arrojar luz sobre la contribución de la agencia individual a la diplomacia antihabsburgo a principios del siglo XVI.
Gabriel de Zayas, "secretario de Berbería": la formación de una nueva negociación territorial en la Monarquía de Felipe II
Authors: Soto Garrido Miguel
Published: December 2024

Este artículo analiza la formación de la “secretaría de Berbería” en el reinado de Felipe II. Esta nueva negociación territorial surgió al calor de las relaciones con la dinastía saadí y se gestó en torno a la figura de Gabriel de Zayas. Desde 1574 este secretario creó un grupo de trabajo cuyos procedimientos se maduraron, profesionalizaron y engarzaron con la provincia de Andalucía. El éxito de este sistema, que discurría por unos mecanismos informales parejos a la autoridad e influencia de Zayas, residía en ser el centro de un triángulo que conectaba tres vértices: el acceso al rey por medio de las facciones cortesanas, los consejeros vinculados al mundo portugués y la casa de Medina Sidonia. Tras la muerte de Zayas en 1593 sus procedimientos, plenamente madurados, se integraron en la secretaría de Estado a cargo de Martín de Idiáquez, si bien manteniendo un amplio margen de maniobra fuera de los mecanismos oficialmente regulados.
Responsabilidad social y la disposición en instituciones educativas
Authors: Guerrero Fernández Jorge Angel
Published: December 2024

The purpose of this study was to examine whether social responsibility is related to dispositional attitudes and whether it is possible to improve and strengthen the knowledge of these variables in education. The methodology was descriptive, correlational, non-experimental and cross-sectional with a quantitative approach. The survey was used as a data collection technique with a Likert scale questionnaire. The study population was 193 people belonging to the community of the Public Educational Institution N°20123, Capilla de Asia, Cañete, with a sample of 130 people including administrative staff, teachers and students from the third year of secondary school onwards. The research was carried out during the year 2022. The results show the perception and the level of knowledge that the population has about social responsibility and the dispositional attitude, which was positive and moderate, so that through sustainable actions in work plans and activities it is possible to strengthen the concepts raised in this research in the participating actors of the educational community studied.
El temor a perder el empleo como motivación laboral
Authors: Burillo Terreros Rossy Nataly
Published: December 2024

One of the most complex issues in organizations is work motivation; however, the phenomenon of fear as a motivating force at work has been little examined. Thus, the aim of this paper is to examine fear, understood as a work motivator, to boost performance and productivity. A qualitative methodology with a hermeneutic approach is used to explore the fear of losing one’s job as a motivating force in the work environment. Likewise, it is an exploratory and descriptive-analytical approach based on the review of scientific papers and a thematic analysis to identify patterns and recurring themes. The main results reveal that the fear of losing one’s job impacts both employees and the organization in general, generating psychological, physiological and behavioral reactions that affect productivity and social interactions, also damaging the culture and work environment. Fear can encourage work efforts in the short term, but it damages emotional and psychological well-being in the long term, decreasing creativity and innovation. In conclusion, based on the theories analyzed, it was found that, although fear can boost temporary performance, its effectiveness as a motivational driver depends on intrinsic factors and the balance between rewards and consequences. Fear can negatively affect competitiveness and organizational sustainability; therefore, leaders are recommended to apply balanced strategies that prioritize employee well-being, avoiding generating unnecessary anxiety, in order to improve performance and quality of work.
El rol del control interno y la gestión empresarial: caso de una compañía minera en Perú
Authors: Valdivia Holguin Ximena Rocio
Published: December 2024

Peru is a country that stands out for its important mining sector; therefore, the following study analyzes the relationship between internal control and business management within a mining company in the country. The methodology considers the basic type, descriptive-correlational level, and cross-sectional design, the universe being 379 workers of the mining company analyzed and the sample is made up of 178 workers. The research instruments used to obtain data and measure research variables are questionnaires and content analysis. The results revealed a significant relationship between internal control and corporate governance. Therefore, it can be concluded that the company lacks strength with regards to internal control culture. It is therefore recommended that training and awareness programs be implemented to strengthen internal control culture, so that employees may understand the importance of their role in business management, and the effective implementation of these controls.
Análisis correlacional del marketing interno y la fidelización del cliente interno como estrategias para incrementar la competitividad y la productividad
Authors: Arias Borda Eddy Hugo
Published: December 2024

El presente estudio tuvo como objetivo principal determinar la relación entre el marketing interno y la fidelización del cliente interno de una empresa gráfica en Lima, Perú. Como método se adoptó un enfoque cuantitativo, con diseño de investigación aplicada, de nivel correlacional y no experimental. Se utilizó la encuesta mediante un cuestionario de 70 items distribuido entre 106 empleados seleccionados mediante muestreo aleatorio simple. Asimismo, se trabajó con el coeficiente de correlación de tipo no paramétrica de Rho de Spearman para medir la fuerza de asociación entre las variables planteadas. La fiabilidad de este instrumento de medición fue evaluada mediante el coeficiente alfa de Cronbach, el cual arrojó un valor de 0.972, indicando una alta fiabilidad y cohesión entre las preguntas del cuestionario. Los resultados obtenidos revelan que existe correlación entre el marketing interno (0.719) y las dimensiones del marketing interno como la motivación, que obtuvo la puntuación más alta (0.706), seguida por desarrollo laboral (0.668), soporte organizacional (0.601) y comunicación interna (0.577) con la variable fidelización del cliente interno. El estudio concluye que la mejora sistemática en la estructura organizacional y en los programas de comunicación interna, así como en la motivación constante de la fuerza laboral en todos los niveles jerárquicos, son los elementos claves en el marketing interno a fin de promover una visión compartida entre los colaboradores para garantizar el desarrollo competitivo y la productividad.
Responsabilidad social empresarial y su impacto en el desempeño financiero: una revisión sistemática
Authors: Fernandez Aliaga Denys Marco
Published: December 2024

This study on corporate social responsibility and its impact on financial performance focused on quantitative, explanatory research from the past two years. A sample of 47 articles published in the journal Scopus between 2022 and 2023 was analyzed. The research aimed to provide a systematic review of various regression methods applied in studies across different economic sectors. The approach followed was a systematic literature review, with inclusion and exclusion criteria. The findings revealed that the industrial economic sector received the most attention compared to others, and the most frequently employed regression methods were the fixed effects method (FEM), structural equation modeling (SEM) techniques, and partial least squares structural equation modeling (PLS-SEM). Additionally, there was a greater concentration of studies conducted in developed economies compared to emerging ones. This work contributes by offering a comprehensive guide to the most commonly used regression methods across economic sectors, serving as a reference for future research.
On the language ecology of German in Denmark
Authors: Geyer Klaus
Published: December 2024

This article analyses the German language in Denmark in its various contexts of language ecology. A crucial aspect of this approach is that German is not only considered, for example, as an intensely taught and learned foreign language in the education system or as the vivid language of the German minority in the south of Jutland, but that all those areas in which the German language plays a role in the Danish society are dealt with, thus including the enormous importance of German in Danish tourism and in business and economic life in general. In this way, a systemic overview over the language ecology of German in Denmark can be reconstructed.For a better understanding of today’s situation of German in Denmark, a brief historical outline of the centuries of intensive language contact between German and Danish is provided at the end of the article.
Don’t Miss It! Past Code Update Articles Available Online
Authors:   American Academy of Pediatrics
Published: December 2024

It’s time to implement the 2025 Current Procedural Terminology (CPT®) code changes. Multiple articles published in the November and December 2024 issues of AAP Pediatric Coding Newsletter™ provide either an overview or in-depth review of the procedure code changes for services on and after January 1, 2025. To review any of these articles, visit AAP Pediatric Coding Newsletter online at https://publications.aap.org/codingnews and select the “All Issues” tab.
A nagyérocclusióval járó ischaemiás stroke endovascularis ellátásának anesztéziája
Authors: Szabó-Maák Zoltán , Molnár Viktória , Kis Balázs , Belán Ivett , Fülesdi Béla
Published: December 2024

A nagyérocclusióval járó ischaemiás stroke endovascularis terápiája intubáció
nélküli szedáció mellett vagy intubációval járó általános anesztéziában is
kivitelezhető. A jelenlegi irányelvek szerint a döntést egyénileg, a klinikai
kép függvényében kell meghozni. Mindkét módszer mellett és ellen is szólnak
érvek, ugyanakkor az anesztézia előnyben részesített módja centrumonként
változik. A pontos anesztéziai fogalmak és szedáció definíciója a
stroke-ellátásban nem egységes, bár az utóbbi években világszerte terjedt a
neurointervenció során a monitorozott anesztéziai felügyelet kifejezés
használata, mely sürgős szituációban, potenciálisan instabil stroke-beteg
szedációját jelöli. Az anesztézia módjával kapcsolatos eddigi vizsgálatok
ellentmondásos eredményeket hoztak, időközben pedig az anesztéziai tevékenység
jelentősége átértékelődött. A mechanikus thrombectomia 2015-ös bevezetése körüli
években megfigyeléses és retrospektív vizsgálatok alapján rosszabb funkcionális
stroke-kimenetellel hozták összefüggésbe az általános anesztéziát a szedációval
szemben, elsősorban az általános anesztéziával együtt járó időveszteség és a
gyakoribb hypotensiós időszakok miatt. Később az anesztéziai módszerek
összehasonlítására tervezett randomizált, kontrollált vizsgálatok nem mutattak
különbséget az általános anesztézia és a szedáció között. Sőt, több vizsgálat
egybehangzó eredménye alapján, az általános anesztézia mellett végzett
mechanikus thrombectomia jobb recanalisatiós eredményeket mutatott, egyes
vizsgálatok szerint pedig a hosszú távú funkcionális kimenetel is kedvezőbb. Az
általános anesztézia igazi előnye csak azon stroke-centrumokban valósítható meg,
ahol folyamatosan elérhető neuroanesztéziai csoport, és ellátásszervezési,
valamint hemodinamikai protokollok alapján minimalizálható az időveszteség és a
hypotensiós időszak aránya. Orv Hetil. 2024; 165(51): 1999–2007.
A megromlott egészség okozta munkaidő-veszteség Magyarországon 2021-ben
Authors: Vitrai József
Published: December 2024

Bevezetés: A munkavállalók egészségének megromlása a munkáltatók
számára csökkent teljesítményt, a munkavállalóknak alacsonyabb jövedelmet
jelent, az országnak növekvő egészségügyi kiadásokat okoz.
Célkitűzés: Az egészség megromlása miatt fellépő 2021. évi
munkaidő-veszteség, annak nemi különbségeinek, illetve 2019-hez viszonyított
változásának, továbbá a magyar értékek más országokéitól való eltérésének
vizsgálata. Módszer: A 30–64 éves korosztályban a
munkaidő-veszteség a korlátozottság és az „idő előtti” halálozás miatt 2021-ben
elveszett munkanapok számával, illetve az elhunytaknak a nyugdíjkorhatárig
elveszett évei számával került elemzésre. A korlátozottsági és a halálozási
adatok a Global Burden of Disease Study adatbázisából származnak; felhasználásra
kerültek még a Központi Statisztikai Hivatal és az Eurostat népességi, illetve
halálozási adatai. A magyar adatokat a visegrádi országok és Ausztria megfelelő
értékeivel vetette össze a tanulmány. Eredmények: 2021-ben a
30–64 évesek minden 7. munkanapja kiesett, azaz 37 munkanapon egyáltalán nem
tudtak dolgozni. Emellett a nyugdíjig ledolgozható, több mint 117 ezer év is
elveszett. Nőknél a korlátozottság, férfiaknál inkább a halálozás okozta a
munkaidő-veszteséget. 2019-hez képest az egy főre számított kiesett munkanapok
7%-kal, a halálozás jövőbeli veszteségei 40%-kal növekedtek. Magyarország a
korlátozottság miatt elveszett napok számában a többi országhoz hasonló értéket
mutatott, de a halálozások száma a többiekhez képest jóval nagyobb volt.
Megbeszélés: A korlátozottság női többlete és a halálozás
férfitúlsúlya mögött a betegségekhez való eltérő viszonyulás feltételezhető: a
férfiak jobbnak tartják egészségüket, emiatt ritkábban vesznek igénybe
egészségügyi ellátást. A más országokhoz képest kiemelkedő magyar halálozás a
megelőzés és az orvosi ellátás gyengébb voltára utal. A megelőzhető és az orvosi
beavatkozással elkerülhető halálozás nagy aránya jórészt az egészségügyi
rendszer működésének hiányosságaira, és nem az orvoshoz fordulási kisebb
hajlandóságra vezethető vissza. Következtetés: Az eredmények
rámutatnak, hogy a munkaidő-veszteségek csökkentése nemenként eltérő
megközelítést igényel. A veszteségek enyhítéséhez a népegészségügyi és az orvosi
ellátás javulása szükséges. Az ország versenyképességének növeléséhez továbbá
elengedhetetlenek az egészséges életmód előmozdítását és az azt támogató
környezet kialakítását célzó intézkedések is. Orv Hetil. 2024; 165(51):
2026–2032.
Exploring the potential and performance constraints of Ni-rich LiNi$$_{0.9}$$Co$$_{0.1}$$O$$_2$$ cathodes for lithium-ion battery application
Authors: Ikuerowo Temitayo Ojuetimi , Salawu Omotayo Akande , Tomomewo Olusegun Stanley
Published: December 2024

The high-capacity but unstable LiNiO$$_2$$

2

(LNO) cathode material for lithium-ion batteries can be improved through partial substitution with cobalt. First-principles calculations were performed to study the impact of 10% cobalt doping on the structural and defect properties of LiNi$$_{0.9}$$

0.9

Co$$_{0.1}$$

0.1

O$$_2$$

2

(NC91). Results reveal that the Ni antisites prefer to be positioned farther away from the Co atom. This work provides fundamental insights into the structure–property relationships resulting from low levels of cobalt doping in Ni-rich cathodes.

Graphical abstract
Marketing study of selective serotonin reuptake inhibitors for the treatment of post-traumatic stress disorder in military servants and war veterans
Authors: Fediak Iryna , Volosheniuk Tetiana
Published: December 2024

The aim of the work: to present the results of a marketing study of medicinal products of the ATC classification group N06AB "Selective serotonin reuptake inhibitors" (SSRIs) in terms of registration and legal status, the state of the wholesale and retail market, presence in socio-economic regulatory lists of medicinal products, as well as to evaluate the results of an anonymous survey of doctors regarding the prescription of SSRIs to military personnel and war veterans with post-traumatic stress disorder (PTSD).
Materials and methods. Methods such as analysis, synthesis, comparison, specification, systematization, generalization, and reliability assessment were used; an anonymous survey of 35 psychiatrists and 25 neurologists was conducted regarding the prescription of drugs for patients with PTSD.
Results and discussion. It was found that SSRIs should be considered as first-line pharmacotherapy for military personnel with PTSD. At the same time, escitalopram, which, according to the literature, demonstrates the best safety and efficacy indicators, which was preferred by 97% of the surveyed doctors, the market of which showed the greatest growth in terms of assortment and which was most numerously included in the List of Drugs Subject to Reimbursement, remains absent from the updated Unified Clinical Protocol for the Treatment of PTSD.
Conclusions. 100% of doctors confirmed the choice of SSRIs, among which, with a probability of type I error α = 0.05, a reliable probability of p ≥ 0.95 regarding the unanimity of responses, psychiatrists most often prescribed escitalopram and sertraline, neurologists - citalopram and escitalopram, in general - escitalopram.
As of 01.10.2024, 45 trade names of SSRIs were registered in Ukraine (4 - fluoxetine, 1 - citalopram, 7 - paroxetine, 9 - sertraline, 2 - fluvoxamine, 22 - escitalopram), 80% of the drugs were of foreign origin, 20% of which were manufactured to order by domestic manufacturing companies. Imported drugs came from 15 countries, most of them - from India (28%); among 9 domestic companies, Pharma Start LLC supplies the largest number of medicines (33%).
It was found that currently the lowest prices for drugs in Ukraine are offered by the drug booking service Tabletky.UA. The state reimburses the cost of PTSD treatment with the most affordable drugs paroxetine and sertraline (1 trade name each), fluoxetine (3), escitalopram (5). Therefore, given the results of the study, it is recommended to include escitalopram in the Unified Clinical Protocol of Primary and Specialized Medical Care “Acute Stress Reaction. PTSD. Adaptation Disorders”.
[1,2,4]triazino[2,3-c]quinazoline hybrids with azole and azine heterocycles: design, synthesis, antibacterial and antiradical activity
Authors: Grytsak Oleksandr , Schabelnyk Kostiantyn , Kinichenko Anna , Komarovska-Porokhnyvets Olena , Lubenets Vira , Voskoboinik Oleksii , Kovalenko Serhii
Published: December 2024

The aim: Present paper devoted to the purposeful search of a promising biologically active compounds among heterocyclic hybrids combining in their structure [1,2,4]triazino[2,3-c]quinazoline system and a "pharmacophoric" azole or azine fragment, joined through an alkylthio linker group.
Material and methods: Methods of synthetic organic chemistry were used to prepare target compounds. The purity and structure of the synthesized compounds were confirmed by elemental analysis, HPLC-MS, and ¹H NMR spectrometry. Radical-scavenging activity was estimated using DPPH-assay, antimicrobial activity was studied by serial dilution method.
Results: A combinatorial library of 30 novel heterocyclic hybrids was designed and synthesized. The target compounds were obtained via the interaction of 6-chloroalkyl-3-R-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones and corresponding heterocyclic thiones in the presence of a base. The synthesized compounds were studied for their radical scavenging and antimicrobial activity. Most of the obtained compounds revealed low antimicrobial activity against studied strains. However, the heterocyclic hybrid combining triazinoquinazoline, thiadiazole, and 4-fluorophenyl moieties (compound 2.14) inhibited the growth of S. aureus, E. coli, and M. luteum. Among the obtained compounds, five heterocyclic hybrids demonstrated significant DPPH radical scavenging activity (30.41-43.53 %). The "structure-activity" correlations were evaluated and discussed. It was estimated that "linker" alkylthio-group modification resulted in the most pronounced changes in the radical scavenging activity of obtained compounds.
Conclusions: Triazinoquinazoline-based heterocyclic hybrids are promising objects for further screening for antimicrobial activity and pharmacological effects associated with antiradical properties
Analyst qualification for compliance with normal analytical practice for pipette use
Authors: Leontiev Dmytro , Chykalova Svitlana , Asmolov Vitalii , Volovyk Natalia , Petrus Vasyl , Gryzodub Oleksandr
Published: December 2024

Aim. This work aimed to assess the proficiency of routine medicine quality control analysts for compliance with the normal analytical practice (NAP) requirements for the standard pipette aliquoting analytical procedure.
Materials and methods. Certified 2 mL Mohr pipettes provided by the proficiency testing provider; a gravimetric procedure for determining the delivered volume and the corresponding equipment that meets the ISO 4787:2021 requirements; methods of mathematical statistics.
Results and discussion. The participants conducted five measurements of the delivered volume using the gravi-metric method. The acceptance criteria for the results were developed to ensure reliable verification of volumetric glassware, where the random analyst’s error had to be insignificant compared to the requirements for the error of the volumetric glassware, as well as compliance with NAP in routine analysis, particularly regarding individual deviations. A total of 64 analysts from 22 laboratories participated in the testing. Of these, 61 analysts achieved satisfactory results by all criteria. For 44 % of the participants, the deviations from the nominal value were signif-icant as per the ISO requirements for Class A pipettes. Individual and average deviations from the nominal value were calculated and analyzed, allowing for assessing the participant results’ precision and the correctness of their decisions regarding the ISO requirements for measuring equipment. The accuracy of the participants’ calculations, the instruments used, and the testing conditions were evaluated. Issues with calculations, rounding of results, and non-compliance with the requirements concerning metrological balance qualification, thermometer calibration, laboratory environmental conditions, and pipette condition evaluation were revealed.
Conclusions. Findings indicate that participants can meet NAP requirements and perform pipette verification with high reliability, which aligns with the key analyst qualification requirements. The results confirm that for personnel qualification, it is necessary to use pipettes with certified delivered volume with acceptable uncertainty. The devel-oped testing procedure can be used for intra-laboratory proficiency testing
Stress management in "Music performance practice" classes
Authors: Duboviy Zakhar
Published: December 2024

The article is dedicated to studying the phenomenon of music performance anxiety, focusing on the characteristics of stress development during music-related creative activities. It is determined that musical activities, particularly public one, are often accompanied by increased anxiety in performers due to fear of making mistakes, the responsibility to the audience, and the need to demonstrate high levels of mastery. Anxiety, as a normal physiological response to stress, can have both positive and negative effects on performers’ productivity.
An analysis of effective methods, approaches, and strategies for stress management in productive music performance is provided. It is shown that the causes of stress states among music pedagogy students can be emotional tension, technical difficulties, and time constraints.
The cognitive-behavioural, emotionally-focused, neuropsychological, body-oriented, social-communicative, and technological approaches that can be implemented within the stress management framework in "Music Performance Practice" classes are revealed.
The article justifies the need for a comprehensive approach to managing anxiety and stress, using cognitive-behavioural methods, physiological techniques, and a social-communicative approach. This will not only aid students reduce their anxiety levels but also enable them to operate stress as a tool for achieving performance productivity and high professionalism.
Based on the results of the methodology trial, it is concluded that integrating stress management technologies into the content of the "Music Performance Practice" course is advisable.
Further research aims to develop a comprehensive pedagogical system that integrates stress management strategies into the educational process
Model of formation of innovative competence of students of basic general secondary education in the process of learning physics
Authors: Bondarenko Viktoriia , Kryvylova Olena
Published: December 2024

The formation of innovative competence in students during the process of learning physics has become a promising strategic direction for the development of physical education. Based on the results of the analysis of scientific psychological and pedagogical literature, current educational practices for preparing students of basic general secondary education, and trends in its development, the need to update the content of physical education in the context of forming innovative competence and mastering the scientific and pedagogical experience of its formulation in the conditions of the New Ukrainian School has been identified.
The article highlights the process of creating a model for forming innovative competence in students of basic general secondary education during physics learning: it clarifies the essence of modeling as a means of scientific cognition and identifies the peculiarities of creating a pedagogical model; the foundational principles for developing the model of innovative competence formation in students during physics education are outlined; the content of the main blocks of the developed model is defined.
The psychological and pedagogical conditions for the implementation of the developed model are indicated: stimulating positive and productive motivation for students to master physical education; considering the achievements of science, technological developments, and labor market requirements in the content of education; involving students in research, project, and interactive activities in line with educational standards, curricula, and educational programs; actively using modern pedagogical approaches to teaching and assessment, innovations in the education sector, interdisciplinary teaching practices, methods and tools that promote the development of students’ research and inventiveness competencies; organizing the educational process as a pedagogical interaction, aimed at the development of the individual and their preparation for solving life tasks of varying complexity
La racionalización del sufrimiento: una aproximación epistémica al problema evidencial del mal en el mundo
Authors: Miranda Rojas Rafael
Published: December 2024

Hay sufrimiento en el mundo, hay mal en el mundo. Existe evidencia de ambos. No todo sufrimiento parece ser con vistas a un bien mayor. Es decir, parece haber casos de mal gratuito o injustificado. El pasado 2 de febrero del 2024, observamos en Viña del Mar - Chile las trágicas consecuencias de un devastador incendio forestal, probablemente provocado intencionalmente por el ser humano. Ante escenarios de este tipo, el desafío epistémico para quienes creemos en Dios es preguntarnos si este es un caso de mal innecesario y si, de ser así, tiene alguna implicancia para la creencia en Dios. En este escrito plantearé los riesgos de racionalizar el sufrimiento, sin que ello implique que la búsqueda de razones sobre el mismo (su explicación) derive en una justificación indirecta del mismo. En última instancia, se trata de distinguir entre evaluar las causas de un evento, la justificación del evento y la evaluación ética del mismo.
Factor Analysis of the Effects of Education Systems During the Covid-19 Pandemic Process on Manisa Celal Bayar University Students
Authors: İncekırık Aynur , İşseven Merve , İşçi Güneri Öznur
Published: December 2024

This study aims to examine the opinions and thoughts of students studying at Manisa Celal Bayar University Faculty of Economics and Administrative Sciences in the 2022-2023 academic year regarding distance and face-to-face education systems during and after the Covid-19 pandemic process, by factor analysis.The findings obtained as a result of the factor analysis were examined and interpretations were made. The data used in the study was collected by survey technique. Analyzes were carried out using the SPSS-22 statistical package program and results were obtained using explanatory factor analysis, one of the multivariate statistical techniques.The number of students who will participate in the survey was determined by taking into account their departments using the stratified sampling technique, provided that they took courses with the distance education model during the Covid-19 pandemic and continued their education with the face-to-face education model after the pandemic. In this way, 342 of the 4518 students studying at the faculty were determined as the sample and the study was conducted with 342 students who fully responded to the survey. The findings obtained as a result of the explanatory factor analysis applied Accordingly, it has been observed that the effects of the Covid-19 pandemic process and subsequent education systems on students are explained by two factors. The first of these two factors is named "Positive Effects of Face-to-Face Education" and the second is called "Negative Effects of Face-to-Face Education". These named factors explain 69% of the total variance.
Numerical model of the motion of artificial Earth satellites
Authors:   Tomsk State University, Aleksandrova Anna G. , Popandopulo Nikita A. ,   Tomsk State University, Kucheryavchenko Nikita A. ,   Tomsk State University, Avdyushev Viktor A. ,   Tomsk State University, Bordovitsyna Tat’yana V. ,   Tomsk State University
Published: December 2024

This paper presents the latest version of the software package "Numerical model of the motion of artificial Earth satellites". Two versions of the program have been developed: one for a personal computer and another for the "SKIF Cyberia" supercomputer complex with parallelization of computational tasks at Tomsk State University. The software can take into account the following perturbing factors: geopotential nonsphericity effect, secular variations in the first zonal harmonics and tidal deformations within the Earth, gravitational influence of the Sun and Moon, radiation forces, atmospheric drag acceleration, influence of major planets, selenopotential harmonics, and relativistic effects. To study the chaotic nature of the orbital motion of near-Earth satellites, the developed software package is improved with the possibility of calculating the MEGNO parameter. The numerical model allows the user to additionally calculate resonant parameters using analytical and numerical techniques when studying the features of the orbital evolution of near-Earth objects. In the presented version of the software package for a personal computer, the interaction with the user is carried out by means of the software interface. The interface additionally allows one to create an input text file based on the completed data for further use in the version for the "SKIF Cyberia" supercomputer.
Assessment of the upper and lower levels of permissible strains in the manufacture of sheet and thin-walled parts based on the forming limit diagram
Authors:   Komsomolsk-on-Amur State University, Feoktistov Sergey I. , Andrianov Ivan K. ,   Komsomolsk-on-Amur State University
Published: December 2024

Forming limit diagrams (FLDs) are currently widely used in the analysis of sheet metal forming without destruction and in assessing the technological capabilities of metal forming. This paper is devoted to the FLD-based assessment of the maximum and minimum limiting strains of the forming of thin-walled workpieces. Theoretical analysis of well-known criteria is used, including the criteria for the occurrence of scattered and localized necks, the so-called energy (static) criteria, as well as the criterion of abrupt local thinning of the sheet, the so-called kinematic criterion. This paper considers a two-way analysis of the forming limits of thin-walled workpieces according to FLDs, which allows one to determine the upper and lower estimates of the limiting strains of the forming. The analysis is based on the FLD study results obtained by various authors and published both in Russia and abroad. The presented research results can be used as a first-order analysis tool for evaluating and predicting the technological capabilities of the molded material in the manufacture of thin-walled parts. They are also relevant to metal processing by pressure and plastic forming of thin-walled sheets.