bluuebunny/crossref_metadata_2025 huggingface dataset:
التركيب العاملي للمتغيرات الانثروبومترية والبدنية والحركية للاعبي المبارزة
Authors: Assis. Prof. Dr. Noor Hatem  AlHaddad  , Prof. Dr. Dhafer Namoos AlTaie.
Published: March 2024

مما لا شك فيه إن التعرف على البناء العاملي للقياسات الجسمية والقدرات البدنية والحركية للاعبي المبارزة والتي تمثل العوامل المستخلصة وتصلح كبطارية قياس لها. استخدم الباحثان المنهج الوصفي بالأسلوب المسحي على عينة بلغت (60) لاعباً من مركز الموهبة الرياضية بالمبارزة في بغداد وديالى. ومحدداً للقياسات الجسمية والقدرات البدنية والحركية واختباراتها على ضوء ما ورد منها في المصادر والمراجع العربية، ومن ثم تنفيذها وإجراءها للحصول على البيانات ومعالجتها إحصائياً باستعمال التحليل العاملي كأحد أفضل وأصدق وسائل الإحصاء المتقدم، وفي ضوء نتائج التحليل العاملي للقياسات الجسمية والاختبارات المرشحة (25) قياساً واختباراً ، تم قبول الأربعة عوامل مستخلصة وتفسيرها وتسميتها وهي (الأطوال، القدرات البدنية، القدرات الحركية، السرعة الانتقالية)، لحصولها على أعلى التشبعات وهذا ما حقق الهدف العام من البحث. والأسترشاد بالعوامل المستخلصة من الدراسة كأساس في اختياروانتقاء لاعبي المبارزة. وفي ضوء الشروط التي وضعت لقبول العامل، فقد تم رفض ستة عوامل لعدم استيفاءها شروط القبول ومن ثم عدم تمثيلها للبطارية المنشورة. ويوصي الباحثان باستخدام القياسات الجسمية والاختبارات البدنية والحركية في البرامج التدريبية للوقوف على مستوى لاعبي المبارزة. وإجراء البحوث والدراسات المشابهة للقدرات الآخرى (النفسية، الفسيولوجية, العقلية) على نفس الفئة أو الفئات العمرية الأخرى.
Hubungan Perilaku Penggunaan Laptop dengan Keluhan Musculoskeletal Disorders (MSDs) pada Dosen
Authors: Wardani Tyas Lilia , Fajariani Ratna , Qadrijati Isna
Published: March 2024

Pandemi COVID-19 yang melanda Indonesia mengharuskan adanya physical distancing dan pengurangan kegiatan di luar rumah. Hal ini mendorong masyarakat untuk mengubah gaya hidup di berbagai bidang termasuk pada bidang pendidikan. Pendidik termasuk dosen, melakukan e-learning yang dapat berdampak negatif terhadap kesehatan fisik akibat perilaku penggunaan laptop saat Work from Home (WFH). Salah satu dampak negatif pengunaan laptop yang buruk adalah Musculoskeletal Disorders (MSDs). Pada penelitian ini parameter perilaku penggunaan laptop adalah ukuran laptop, durasi dan frekuensi penggunaan laptop serta postur tubuh saat menggunakan laptop. Penelitian ini bertujuan menganalisis hubungan perilaku penggunaan laptop dengan keluhan Musculoskeletal Disorders (MSDs) pada dosen. Penelitian ini termasuk penelitian observasional analitik melalui cross sectional approach. Sampel penelitian ini sebanyak 175 dosen yang dipilih secara simple random sampling. Kuesioner perilaku penggunaan laptop yang telah diuji validitas dan reliabilitasnya serta kuesioner Nordic Body Map yang dibagikan melalui Google form digunakan sebagai instrumen penelitian. Sebagai teknik analisis data digunakan uji korelasi Somers’d. Hasil uji korelasi Somers’d menunjukkan bahwa variabel ukuran laptop dan postur tubuh saat menggunakan laptop memiliki nilai p ​​= 0,003 dan 0,022, sedangkan variabel durasi dan frekuensi penggunaan laptop memiliki nilai p = 0,971 dan 0,732. Kesimpulan penelitian ini menunjukkan bahwa perilaku penggunaan laptop yang berkorelasi signifikan dengan keluhan MSDs adalah ukuran laptop dan postur tubuh saat menggunakan laptop.
Faktor Risiko Mycobacterium Tuberculosis, Kepadatan Hunian dan Kualitas Fisik Rumah Penderita TB Paru
Authors: Rahayu Onna Nurul Fitria Diah Ambar
Published: March 2024

Kondisi rumah tidak memenuhi syarat rumah sehat dapat menimbulkan berbagai penyakit. Tuberkulosis adalah salah satu penyakit yang dapat disebabkan faktor lingkungan rumah. Kecamatan Pabean Cantian Surabaya adalah wilayah yang memiliki penemuan kasus baru tertinggi di Surabaya. Tujuan penelitian ini adalah untuk mengetahui Mycobacterium tuberculosis udara, kepadatan hunian dan kualitas fisik rumah apakah memiliki faktor risiko terjadinya tuberkulosis paru pada penderita TB di Kecamata Pabean Cantian. Kualitas fisik rumah yang dinilai meliputi jenis lantai, pencahayaan dan kelembapan ruang kamar tidur penderita. Penelitian menggunakan analisa kuantitatif deskriptif dengan rancangan case kontrol study perbandingan 1:2. Kelompok kasus adalah penderita TB paru BTA positif pengobatan 2-5 bulan sebanyak 4 responden dan kelompok kontrol adalah penderita TB BTA negative pengobatan 2-5 bulan sebanyak 8 responden. Pengumpulan data dengan instrumen lembar observasi, pengambilan sampel udara menggunakan alat MASS untuk mengetahui bakteri Mycobacterium tuberculosis di udara ruang kamar ridur, thermohygrometer, lux meter dan meteran. Hasil penelitian menunjukkan  Mycobacterium tuberculosis udara ruang (OR = 1,8), kepadatan hunian ruang (OR = 1,8), pencahayaan (OR = 1,8), kelembapan (OR = 1,8) dan jenis lantai (OR = 2,3) merupakan faktor risiko terjadinya TB paru. Seluruh variabel bebas menjadi faktor risiko terjadinya TB paru, dimana jenis lantai yang tidak memenuhi syarat menjadi faktor risiko tertinggi terjadinya TB paru. Sehingga perlu adanya peningkatan kesadaran pentingnya lingkungan rumah yang memenuhi syarat kesehatan.
Small extracellular vesicles derived from acute myeloid leukemia cells promote leukemogenesis by transferring miR-221-3p
Authors: Li Mengyu , Sun Guohuan , Zhao Jinlian , Pu Shuangshuang , Lv Yanling , Wang Yifei , Li Yapu , Zhao Xiangnan , Wang Yajie , Yang Shangda , Cheng Tao , Cheng Hui
Published: March 2024

Small extracellular vesicles (sEV) transfer cargos between cells and participate in various physiological and pathological processes through their autocrine and paracrine effects. However, the pathological mechanisms employed by sEV-encapsulated microRNA (miRNA) in acute myeloid leukemia (AML) are still obscure. In this study, we aimed to investigate the effects of AML cell-derived sEV (AML-sEV) on AML cells and delineate the underlying mechanisms. We initially used high-throughput sequencing to identify miR-221-3p as the miRNA prominently enriched in AML-sEV. Our findings revealed that miR-221-3p promoted AML cell proliferation and leukemogenesis by accelerating cell cycle entry and inhibiting apoptosis. Furthermore, Gbp2 was confirmed as a target gene of miR-221-3p by dual luciferase reporter assays and rescue experiments. Additionally, AML-sEV impaired the clonogenicity, particularly the erythroid differentiation ability, of hematopoietic stem and progenitor cells. Taken together, our findings reveal how sEV-delivered miRNA contribute to AML pathogenesis, which can be exploited as a potential therapeutic target to attenuate AML progression.
Next-generation strategies to improve safety and efficacy of adeno-associated virus-based gene therapy for hemophilia: lessons from clinical trials in other gene therapies
Authors: Di Minno Giovanni , Miesbach Wolfgang , Castaman Giancarlo , Peyvandi Flora
Published: March 2024

Three major directions for the global progress of adeno-associated virus (AAV) vectors for gene therapies (GT) are analyzed: a) engineering vectors to increase transgene expression; b) aligning interests of the health system with costs and challenges for pharmaceutical industry; c) refining patient eligibility criteria, and endpoints definition. Currently employed AAV vectors may cause toxicity and adverse events. Furthermore, studies in animals do not fully predict risks and clinical benefits of AAV-based GT, and animal models reflecting the heterogeneity of certain clinical settings (e.g., congestive heart failure) are poorly available for improving AAV-based GT. Finally, antisense and gene editing approaches will soon complement gene augmentation strategies for the stable solution of unsolved issues of AAV-based GT. While minimizing toxicity, next-generation AAV vectors should decrease the viral load needed to achieve therapeutic efficacy; be functional in a restricted cellular subset; avoid transgene expression in unwanted cells (e.g., hepatocytes), and escape immune oversight in AAV-based GT. The role of stress-induced apoptosis in the loss of transgene expression in GT should be also explored. Aligning interests and obligations of pharmaceutical industry with those of the health system is critical for AAV-based GT success. Costs and challenges for pharmaceutical industry include a) removing impurities from AAV; b) validating tests to measure treatment efficacy, c) promoting training programs to standardize vector genomes delivery, d) collecting long-term follow-up data, and e) maintaining sustainability and cost-effectiveness of AAV-based GT. In rare disorders with small patient numbers (e.g., hemophilia), clearcut outcomes are mandatory as endpoints of unequivocal efficacy data.
Pelaksanaan Program Rumah Belajar bagi Anak Gampong Meunasah Papeun untuk Meningkatkan Motivasi Belajar dengan Berbasis Hidden Curriculum
Authors: Aulia Ridha , Rizki Agam Muhammad , Zulfikhar Rosa , Junida Dwi Surti , Mutmainnah Inayatul
Published: March 2024

Program Rumah Belajar berbasis Hidden Curriculum merupakan suatu program yang dilaksanakan guna untuk meningkatkan motivasi belajar anak yang terdapat di Gampong Meunasah Papeun. Program ini dilaksanakan karena terdapat suatu keadaan dimana motivasi belajar peserta didik di gampong tersebut dikatakan rendah oleh para orang tua wali. Program ini dilaksanakan dengan empat tahapan meliputi: Observasi, Perizinan, Pelaksanaan, dan Penutupan. Program ini dilaksanakan dan mendapatkan partisipasi dari anak-anak gampong, diperkirakan 40 anak ikut dalam kegiatan Rumah Belajar ini. Kesimpulannya Program Rumah Belajar dengan Basis Hidden Curriculum telah mampu meningkatkan motivasi belajar anak gampong Meunasah Papeun. Program semacam ini haruslah difasilitasi dan harus dilaksanakan secara terus menerus guna menjadikan anak dan peserta didik memiliki semangat dan motivasi belajar yang tinggi dengan demikian maka tujuan pendidikan yang semestinya akan dapat dicapai.
Pendidikan Anti Kekerasan Pada Anak Di Lingkungan Sekolah SMP YLPI Pekanbaru
Authors: Febrianti Lidia , Desvianti Erika , Seruni Puti Mayang , Nurmania Zahra
Published: March 2024

Anak dapat menjadi korban kekerasan disekolah baik dalam bentuk fisik, psikis dan seksual.Kekerasan dapat terjadi pada anak disekolah baik kekerasan fisik, psikis dan seksual. Dianggap bahwa pelajaran kewarganegaraan dan moral yang diberikan oleh guru tidak cukup untuk membangun sifat siswa sehingga mereka tidak terlibat dalam tindak kekerasan, baik sebagai pelaku maupun korban. Hasil dari diskusi dengan kepala sekolah SMP YLPI P. Marpoyan, ditemukan bahwa beberapa perilaku siswa di SMP tersebut menyebabkan konflik dan kekerasan verbal dan fisik. Program anti kekerasan sekolah yang dirancang untuk guru dan siswa menawarkan solusi. Tujuan kegiatan ini adalah untuk menjadikan SMP YLPI Pekanbaru sebagai sekolah yang aman dan bebas dari kekerasan pada anak. “Metode pelaksanaan kegiatan ini terdiri dari tahap pembuatan materi,” penyuluhan dan evaluasi melalui kuis untuk mengetahui sejauh mana pemahaman peserta . Hasil kegiatan ini berupa bertambahnya wawasan dan pengetahuan para siswa dan guru terhadap perilaku kekerasan di sekolah dan bagaimana cara mencegah dan mengatasinya.
Pengenalan Investasi Pasar Modal Bagi Kalangan Mahasiswa dan Pelajar Melalui Seminar Edukasi
Authors: Hidayatullah Syarif , Saefullah Aep , Kohar Abdul , Syahreza Arief
Published: March 2024

Pengabdian masyarakat ini bertujuan untuk mengenalkan investasi pasar modal kepada mahasiswa dan pelajar. Kegiatan melibatkan 100 peserta yang terdiri daari mahasiswa STIE Ganesha dan pelajar SMK Nusantara Ciputat pada tanggal 15 September 2023 di ruang Aula lantai Dua Kampus STIE Ganesha. Metode kegiatan menggunakan seminar, sosialisasi, penyuluhan dan tanya jawab. Hasil kegitana menunjukkan bahwa seminar edukasi efektif dalam meningkatkan pengetahuan dan minat investasi kalangan mahasiswa dan pelajar. Peserta menunjukkan peningkatan yang signifikan dalam pemahaman mereka tentang konsep dasar pasar modal, instrumen investasi yang ada, dan manajemen risiko. Selain itu, peserta juga menunjukkan peningkatan minat untuk memulai investasi di pasar modal setelah mengikuti seminar. Kegiatan memiliki implikasi penting dalam pengembangan dan pelaksanaan seminar edukasi tentang investasi pasar modal bagi kalangan mahasiswa dan pelajar. Seminar ini dapat digunakan sebagai sarana efektif untuk meningkatkan pengetahuan, pemahaman, dan minat investasi mereka, sehingga membantu mereka dalam mengambil keputusan keuangan tepat di kemudian hari.
Implementasi Alat Pengering Sale Pisang Otomatis dan Sistem Penjualan Berbasis Digital Untuk Meningkatkan Kapasitas Produksi dan Omzet Penjualan di UMKM Rasa Alami, Kab. Subang
Authors: Susilawati Susilawati , Buchori Azhis Sholeh , Vernanda Dwi , Rachelia Faadiyah Cheryl
Published: March 2024

UMKM Rasa Alami telah berhasil melakukan peningkatan signifikan dalam produksi dan penjualan sale pisang melalui implementasi beberapa inovasi. Inovasi tersebut meliputi penggunaan alat pengering sale pisang yang memfasilitasi peningkatan volume produksi, adopsi sistem penjualan berbasis ecommerce yang memperluas jangkauan penjualan dan mempermudah prosesnya, serta implementasi sistem keuangan yang dapat diakses melalui smartphone yang memungkinkan mitra UMKM Rasa Alami untuk melakukan kontrol dan pencatatan data keuangan setiap transaksi penjualan. Sebagai hasil dari inovasi-inovasi tersebut, terjadi peningkatan kapasitas produksi sale pisang dari 1,2 ton pada bulan Oktober menjadi 1,8 ton pada bulan November, menunjukkan peningkatan sebesar 55%. Sementara itu, omzet penjualan juga mengalami peningkatan sebesar 50%, dari angka 8.500.000 pada bulan Oktober menjadi 12.749.999 pada bulan November tahun 2023.
PIC-Potenciando Ideas Creativas: Una propuesta educativa para el desarrollo de la creatividad
Authors: Chamorro-Troncos Claudia , Sainz-Gómez Marta , Bermejo-García Rosario , Ruiz-Melero María
Published: March 2024

La creatividad es considerada desde hace unos años como una capacidad o constructo clave que, además de contribuir con el proceso de aprendizaje durante la etapa escolar, evoluciona y trasciende hacia el contexto social. En tal sentido, es conveniente seguir diseñando estrategias o metodologías de enseñanza innovadoras y flexibles que se adapten a las distintas condiciones del alumnado, en las cuales no solo participe activamente el profesorado, como responsable principal de regular los intercambios de aprendizaje dentro del aula, incluyendo el proceso creativo, sino también involucrando a la familia, teniendo en cuenta que es considerada el primer agente que acompaña la curiosidad innata del infante. Bajo esta premisa, se plantea la presente propuesta educativa, cuyo objetivo principal es desarrollar la creatividad desde sus componentes de originalidad, flexibilidad, fluidez y elaboración en los/as estudiantes del último ciclo de Educación Primaria, todo ello a través de actividades lúdicas y participativas; también, se promueve el uso de técnicas como la lluvia de ideas, el juego de roles, entre otras. En este sentido, el resultado general que se espera alcanzar es que los/as estudiantes puedan mejorar su potencial creativo, el cual puede verse reflejado a través de una mayor espontaneidad y autonomía en la elaboración tanto de sus ideas como de sus productos.
Efectos del Covid 19 en la morosidad de los créditos del sector bancario privado del Ecuador 2019-2021
Authors: Cochea-Domínguez Irving , Cañizares-Cedeño Leonardo
Published: March 2024

En el mundo moderno no se ha encontrado una pandemia global de las dimensiones de Covid-19, con un total de 6,94 millones de muertos en todo el mundo (OMS, 2023), con ello las Instituciones financieras enfrentaron los peligros inminentes de una crisis crediticia, a pesar de tomar medidas que contrarresten los efectos adversos, es relevante una evaluación de los efectos que causan las externalidades en la cartera crediticia de los bancos. Por ello, la investigación tiene como objetivo determinar si el COVID 19 tuvo un impacto en la morosidad de la cartera crediticia del sector bancario en el Ecuador, a través de un análisis de quiebre estructural en la serie de tiempo durante el periodo 2019-2021. Para ello, se propone una investigación con diseño experimental – correlacional, utiliza herramientas cuantitativas, con base en el paradigma Explicativo – Positivista. Mediante la aplicación del test de Wald se muestran los años de quiebre estructural de la serie de tiempo, observando una serie con cambios en el año 2000, producto de la dolarización, en el año 2008 a causa de factores políticos, consecuentemente en el año 2019 por una desestabilización política, el 2020 con el ingreso del COVID 19, y la proyección de un 2023 con cambios importantes.
Incidencia del clima organizacional en el desempeño laboral: Cooperativa de Ahorro y Crédito 15 de abril Ltda
Authors: Navarrete-Navarrete María , Vera-Muñoz Lisbeth , Zambrano-Álvarez Gema
Published: March 2024

Un adecuado entorno laboral permite un óptimo rendimiento y satisfacción de los colaboradores que se refleja en el alcance de los objetivos organizacionales, por lo cual el propósito del estudio consiste en evaluar el clima organizacional y su impacto en el desempeño laboral del personal de la Cooperativa de Ahorro y Crédito 15 de abril Ltda. Este estudio fue de carácter cuantitativo, utilizando métodos como el analítico, descriptivo, deductivo e inductivo. Se emplearon como instrumentos de evaluación el cuestionario de Ortega y la herramienta EVADEST que facilitaron una base sólida de información para el desarrollo de los objetivos planteados. Los resultados obtenidos evidencian una percepción positiva en la estructura, proceso y tecnologías, así como en liderazgo, aunque, se identificaron aspectos a mejorar en las dimensiones de propósito u objetivos, recompensas y relaciones entre los miembros. Asimismo, se evidencia que los trabajadores presentan un desempeño medio en calidad de trabajo, responsabilidad, productividad, habilidad y destreza, puesto que, solo se encargan de cumplir con las actividades asignadas. El índice de influencia por dimensiones de las variables de estudio es significativo, demostrando una correlación positiva considerable. Estos hallazgos señalan la presencia de un vínculo entre el clima organizacional y el desempeño laboral, destacando así la importancia de prestar atención en aquellos factores para mejorar tanto el rendimiento de los empleados como los resultados institucionales.
La reparación integral en el delito de violación sexual: Un análisis en el contexto jurídico ecuatoriano
Authors: Aviles-Chimbo Sani , Medina-Medina Vanessa
Published: March 2024

Este estudio explora la reparación integral en el delito de violación sexual en el contexto jurídico ecuatoriano. El estudio se centró en casos emblemáticos que reflejan fallas del sistema legal y las políticas estatales, el objetivo fue analizar el cumplimiento de la reparación integral en el caso del delito de violación sexual. La necesidad de esta investigación se basa en la prevalencia alarmante de violaciones sexuales en Ecuador y la respuesta inadecuada del sistema jurídico. A pesar de la existencia de leyes que condenan estos delitos, la falta de medidas de reparación integral para las víctimas y la ausencia de políticas preventivas eficaces son problemáticas evidentes. La violación sexual tiene un impacto psicológico, físico y emocional significativo en las víctimas, y sin la debida atención y reparación, el camino hacia la recuperación se vuelve inalcanzable. La justicia no debe enfocarse únicamente en el castigo de los autores, sino también en proporcionar a las víctimas la reparación integral necesaria para su recuperación. Este enfoque implica un sistema legal que castigue eficazmente a los delincuentes, prevenga la impunidad, la implementación de políticas preventivas en las instituciones educativas, y el acceso a servicios de salud mental y apoyo psicosocial para las víctimas.
Pedagogía Transformadora desde el Aprender Haciendo
Authors: Pérez-Anagumbla Gladys , Iturralde-Sosa Cristobal
Published: March 2024

La educación es ese proceso de convergencia entre el ser, hacer, conocer y convivir, cuyos nodos reticulares hacen del escolar, el epicentro de toda su direccionalidad, complementada por su contexto, historia y época; por ello, la acción docente, ha de transitar hacia el desarrollo de un aprendizaje útil y sustancial, logrado desde la propia esencia pedagógica, su acervo debe ser pragmático, para que perdure en el sentido cognitivo. De esta manera, se hace imprescindible el aprender haciendo, para que el niño y niña genere conocimientos que sean extrapolados a su vigencia empírica, estas características permiten plantear como objetivo general, describir la pedagogía transformadora desde el aprender haciendo en el contexto de la educación general básica de Ecuador.
The Relationship between Myopia and Obesity in Adults
Authors: Noh Young Ho , Jung Kyoung In
Published: March 2024

Purpose: To investigate the relationship between myopia and obesity through direct measurements of fat content.Methods: A cross-sectional study used a stratified, multistage survey, the Korea National Health and Nutrition Examination Survey (2008–2010). Subjects 19 years or older (n = 10,305) were included. Participants were divided into three groups according to refractive status: myopia (spherical equivalent [SE] ≤ –1.0 diopter [D]), emmetropia (–1.0 D < SE ≤ 1.0 D), and hyperopia (SE > 1.0 D). Obesity was investigated with assessment of fat mass and body mass index or waist circumference. Fat mass was measured with whole-body dual energy x-ray absorptiometry. Body fat percentage was calculated as (total fat mass / body weight × 100).Results: Higher obesity index was found in individuals with myopic eyes after adjustment for age, sex, education level, income status, physical activity, residence, and serum vitamin D level. The significant difference in total body fat percentages among myopia, emmetropia, and hyperopia was significant in the young age group (19–39 years, p < 0.05) but not in the middle age group (40–64 years) and the old age group (≥65 years). Individuals with a higher percentage of total body fat had greater odds ratios for myopia (fourth quartile of body fat; odds ratio, 1.352; 95% confidence interval, 1.178–1.551).Conclusions: An association was found between adiposity and myopia in relatively young adults using direct measurements of fat mass.
The Metaverse Design and Evaluation in Product Design and Development
Authors: Tanaiutchawoot Narucha
Published: March 2024

The COVID-19 pandemic prompted a shift to online learning like SUT-Elearning, Zoom, and Google Classroom. However, these platforms have limitations in replicating classroom dynamics and fostering interaction. Students have low motivation for studying and class participation. The concept of a metaverse classroom is introduced, aiming to enhance engagement by exploring the Metaverse's origins, features, and educational benefits. This study delves into integrating metaverse technology into online education, using Suranaree University of Technology's product design and development course as a model. This course merges project-based and problem-based learning. The investigation outlines the gradual creation of a virtual classroom aligned with these traditional approaches, detailing its functions, components, and limitations. The classroom design is evaluated through student feedback gathered from interviews and surveys. Students assess the design's advantages and disadvantages and compare between the Metaverse, physical classes, Zoom, and video-based learning. Results drawn from feedback from 20 students highlight a preference for physical learning, closely followed by the Metaverse, which excels in engagement over Zoom and video. The Metaverse also excels in real-time interactions, with minor differences in self-directed learning. The study emphasizes the potential of integrating the Metaverse as a catalyst to improve online education and immersive learning. It highlights the ability of metaverse integration to increase real-time engagement and support innovative instructional methods. These methods are vital in effective online education, particularly in the ever-evolving educational landscape.
THE ROLE OF INFORMATION SYSTEMS IN ADVANCING SMART VILLAGES: A RURAL TOURISM CASE STUDY
Authors: Trihandoyo Agus , Hesananda Rizki , Kushandajani Kushandajani , Muhksin Firman
Published: March 2024

Recent studies highlight the need for a deeper understanding of the ways in which information systems, local government policy and community involvement affect the development of rural tourism. By using Structural Equation Modelling and Partial Least Squares (SEM-PLS), the current study aims to analyze the role of information systems, local government policy and local community engagement in rural tourism development. Using data from 69 participants in Watesjaya village, Bogor regency, the study analyzes multiple relationships among latent constructs. The data, encompassing variables such as system quality, information quality, local government policy, local community engagement, destination branding, and rural tourism development, undergoes meticulous reliability and validity assessments. Results from the SEM-PLS analysis unveil significant relationships and insights. Local community engagement emerges as a pivotal factor, positively influencing tourist satisfaction (0.499) and moderately affecting destination branding (0.239). However, local government policy exhibits a less pronounced positive impact on tourist satisfaction (0.069847) and a notable negative influence on destination branding (-0.300460), underscoring the need for policy realignment. Information quality paradoxically influences tourist satisfaction negatively (-0.185) and destination branding (-0.158), highlighting areas for strategic improvement. Meanwhile, information system quality positively affects tourist satisfaction (0.055) and significantly contributes to rural tourism development (0.783). This study provides a better understanding of stakeholders about rural tourism development by focusing on information system quality, information quality, local government policies, and local community engagement The study indicates that information system quality and local community engagement can be valuable indicators for boosting rural tourism development and improving tourist satisfaction.
Note for the Riemann Hypothesis
Authors: Vega Frank
Published: March 2024

Let $\Psi(n) = n \cdot \prod_{q \mid n} \left(1 + \frac{1}{q} \right)$ denote the Dedekind $\Psi$ function where $q \mid n$ means the prime $q$ divides $n$. Define, for $n \geq 3$; the ratio $R(n) = \frac{\Psi(n)}{n \cdot \log \log n}$ where $\log$ is the natural logarithm. Let $N_{n} = 2 \cdot \ldots \cdot q_{n}$ be the primorial of order $n$. A trustworthy proof for the Riemann hypothesis has been considered as the Holy Grail of Mathematics by several authors. The Riemann hypothesis is a conjecture that the Riemann zeta function has its zeros only at the negative even integers and complex numbers with real part $\frac{1}{2}$. There are several statements equivalent to the famous Riemann hypothesis. We prove if the inequality $R(N_{n+1}) < R(N_{n})$ holds for all primes $q_{n}$ (greater than some threshold), then the Riemann hypothesis is true. In this note, we show that the previous inequality always holds for all large enough prime numbers.
Desain Pembangkit Listrik Tenaga Surya Off-Grid dan Monitoring Berbasis Node-Red
Authors: Arief Muhammad Baharuddin , Widyartono Mahendra , Aribowo Widi , Wardani Ayusta Lukita
Published: March 2024

In new renewable energy, the abundant potential of solar energy in Indonesia needs to be utilized effectively, especially in vocational canteens for the purposes of lights and fans. This research aims to design and build an off-grid solar power generation system and Node-Red-based monitoring at the Canteen. The research method used is experimentation through direct observation at the vocational canteen. The tests carried out are the system of SPGS which includes voltage, current, and power and testing monitoring by system sensors and temperature sensors for 5 hours per day in two days. The results obtained are the voltage in the system both panel voltage, AC voltage, and battery voltage are stable and do not exceed the specifications of solar panels. However, the current has increased and decreased although not too drastically and the battery has only decreased by 10%. This is due to the influence of the weather during testing and is not affected by the load power because it does not exceed specifications. In addition, the system sensor has an error of no more than 2% so it can be said that if this system functions optimally and as expected, it can be developed more to save energy.
Prototype isochoric preservation device for large organs
Authors: Șerban Alexandru , Năstase Gabriel , Beșchea George-Andrei , Câmpean Ștefan-Ioan , Fetecău Cătălin , Popescu Irinel , Botea Florin , Neacșu Ion
Published: March 2024

This paper presents the design and prototype of a constant volume (isochoric) vessel that can be used for the preservation of large organs in a supercooled state. This prototype is a preliminary version of a more advanced design. The device consists of a cooling bath operated by a mechanical vapor compression refrigeration unit and an isochoric chamber made of stainless steel. The preservation of organs using supercooling technology in an isochoric chamber requires a continuous temperature and pressure monitoring. While the device was initially designed for pig liver experiments, its innovative design and preservation capabilities suggest potential applications for preserving other organs as well. The isochoric reactor may be used to accommodate a variety of organ types, opening the door for further research into its multi-organ preservation capabilities. All the design details are presented in this study with the purpose of encouraging researchers in the field to build their own devices, and by this to improve the design. We chose to design the device for isochoric supercooling as the method of preservation to avoid the ice formation.
Nanotechnological advances in cancer: therapy a comprehensive review of carbon nanotube applications
Authors: Gao Siyang , Xu Binhan , Sun Jianwei , Zhang Zhihui
Published: March 2024

Nanotechnology is revolutionising different areas from manufacturing to therapeutics in the health field. Carbon nanotubes (CNTs), a promising drug candidate in nanomedicine, have attracted attention due to their excellent and unique mechanical, electronic, and physicochemical properties. This emerging nanomaterial has attracted a wide range of scientific interest in the last decade. Carbon nanotubes have many potential applications in cancer therapy, such as imaging, drug delivery, and combination therapy. Carbon nanotubes can be used as carriers for drug delivery systems by carrying anticancer drugs and enabling targeted release to improve therapeutic efficacy and reduce adverse effects on healthy tissues. In addition, carbon nanotubes can be combined with other therapeutic approaches, such as photothermal and photodynamic therapies, to work synergistically to destroy cancer cells. Carbon nanotubes have great potential as promising nanomaterials in the field of nanomedicine, offering new opportunities and properties for future cancer treatments. In this paper, the main focus is on the application of carbon nanotubes in cancer diagnostics, targeted therapies, and toxicity evaluation of carbon nanotubes at the biological level to ensure the safety and real-life and clinical applications of carbon nanotubes.
Oocyte and embryo culture under oil profoundly alters effective concentrations of small molecule inhibitors
Authors: Rémillard-Labrosse Gaudeline , Cohen Sydney , Boucher Éliane , Gagnon Kéryanne , Vasilev Filip , Mihajlović Aleksandar I. , FitzHarris Greg
Published: March 2024

Culture of oocytes and embryos in media under oil is a cornerstone of fertility treatment, and extensively employed in experimental investigation of early mammalian development. It has been noted anecdotally by some that certain small molecule inhibitors might lose activity in oil-covered culture systems, presumably by drug partitioning into the oil. Here we took a pseudo-pharmacological approach to appraise this formally using mouse oocytes and embryos. Using different culture dish designs with defined media:oil volume ratios, we show that the EC50 of the widely employed microtubule poison nocodazole shifts as a function of the media:oil ratio, such that nocodazole concentrations that prevent cell division in oil-free culture fail to in oil-covered media drops. Relatively subtle changes in culture dish design lead to measurable changes in EC50. This effect is not specific to one type of culture oil, and can be readily observed both in oocyte and embryo culture experiments. We subsequently applied a similar approach to a small panel of widely employed cell cycle-related inhibitors, finding that most lose activity in standard oil-covered oocyte/embryo culture systems. Our data suggest that loss of small molecule activity in oil-covered oocyte and embryo culture is a widespread phenomenon with potentially far-reaching implications for data reproducibility, and we recommend avoiding oil-covered culture for experiments employing inhibitors/drugs wherever possible.
Augmenting context with power information for green context-awareness in smart environments
Authors: Mahmud Umar , Hussain Shariq
Published: March 2024

The increase in the use of smart devices has led to the realization of the Internet of Everything (IoE). The heart of an IoE environment is a Context-Aware System that facilitates service discovery, delivery, and adaptation based on context classification. The context has been defined in a domain-dependent way, traditionally. The classical models of context have been focused on rich context and lack Cost of Context (CoC) that can be used for decision support. The authors present a philosophy-inspired mathematical model of context that includes confidence in activity classification of context, the actions performed, and the power information. Since a single recurring activity can lead to distinct actions performed at different times, it is better to record the actions. The power information includes the power consumed in the complete context processing and is a quality attribute of the context. Power consumption is a useful metric as CoC and is suitable for power-constrained context awareness. To demonstrate the effectiveness of the proposed work, example contexts are described, and the context model is presented mathematically in this study. The context is aggregated with power information, and actions and confidence on the classification outcome lead to the concept of situational context. The results show that the context gathered through sensor data and deduced through remote services can be made more rich with CoC parameters.
Krüpple-like factors in cardiomyopathy: emerging player and therapeutic opportunities
Authors: Gui Le-Kun , Liu Huang-Jun , Jin Li-Jun , Peng Xiao-Chun
Published: March 2024

Cardiomyopathy, a heterogeneous pathological condition characterized by changes in cardiac structure or function, represents a significant risk factor for the prevalence and mortality of cardiovascular disease (CVD). Research conducted over the years has led to the modification of definition and classification of cardiomyopathy. Herein, we reviewed seven of the most common types of cardiomyopathies, including Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), diabetic cardiomyopathy, Dilated Cardiomyopathy (DCM), desmin-associated cardiomyopathy, Hypertrophic Cardiomyopathy (HCM), Ischemic Cardiomyopathy (ICM), and obesity cardiomyopathy, focusing on their definitions, epidemiology, and influencing factors. Cardiomyopathies manifest in various ways ranging from microscopic alterations in cardiomyocytes, to tissue hypoperfusion, cardiac failure, and arrhythmias caused by electrical conduction abnormalities. As pleiotropic Transcription Factors (TFs), the Krüppel-Like Factors (KLFs), a family of zinc finger proteins, are involved in regulating the setting and development of cardiomyopathies, and play critical roles in associated biological processes, including Oxidative Stress (OS), inflammatory reactions, myocardial hypertrophy and fibrosis, and cellular autophagy and apoptosis, particularly in diabetic cardiomyopathy. However, research into KLFs in cardiomyopathy is still in its early stages, and the pathophysiologic mechanisms of some KLF members in various types of cardiomyopathies remain unclear. This article reviews the roles and recent research advances in KLFs, specifically those targeting and regulating several cardiomyopathy-associated processes.
Study of the effect of salt deposition on production capacity and storage capacity in underground gas storage
Authors: Zhongxin Ren , Xiaoping Yang , Dawei Chang , Ning Wang , Da Meng
Published: March 2024

Underground gas storage (UGS) is the most economical and effective means to guarantee stable gas supply. During gas production process, the evaporation of formation water leads to the increase of water content in the gas, and the salinity of the remaining formation water increases. This work applied numerical simulation to analyze the effect of salt deposition on flowing bottomhole pressure, production capacity and storage capacity. The simulation results show that the minimum and maximum pressure of UGS is more likely to be reached during multi-cycle production under the conditions of salt deposition. Under the initial water condition, reservoir drying can improve the gas storage capacity. At the end of the tenth cycle, the storage capacity increases by 1.4%. It is concluded that the study on the impact of formation water evaporation on storage capacity is helpful for the prevention and control of salt formation water in UGS with high salinity.
Ovarian tissue transplantation: 10 years of experience at the Bologna University
Authors: Fabbri Raffaella , Vicenti Rossella , Magnani Valentina , Paradisi Roberto , De Meis Lucia , Raimondo Diego , Arena Alessandro , Venturoli Stefano , Raffone Antonio , Raspollini Arianna , Seracchioli Renato
Published: March 2024

Objective

The efficiency of ovarian tissue transplantation (OTT) was established in terms of ovarian function recovery (95% of cases), number of live births (over 200 worldwide to date) and induction of puberty. Unfortunately, the lack of international registries and the fact that many centers have not yet reported their outcomes, lead to poor knowledge of the exact fertility data. The aim of the study is to describe our experience with OTT to restore ovarian function and fertility.

Methods

This study was designed as a single-center, observational, retrospective, cohort study that includes women who underwent OTT between December 2012 and June 2023 at our center. After approval by the oncologist/hematologist, a small fragment of ovarian tissue was thawed and analyzed to detect the presence of micrometastases before OTT. Thawed ovarian tissue was grafted laparoscopically at multiple sites, including the remaining ovary and pelvic side wall (orthotopic transplantation) and/or abdominal wall (heterotopic transplantation). After OTT, ovarian function was monitored by hormonal assay, ultrasound and color Doppler at approximately 4-week intervals.

Results

Between December 2012 and June 2023, 30 women performed OTT. Prior to OTT, immunohistochemical and molecular analyses revealed no micrometastases in all thawed ovarian tissue samples. In our series of 30 women, 20 of women were on premature ovarian insufficiency (POI), and the remaining ten cases still had oligomenorrhea and difficulty getting pregnant. Among the women with POI before OTT and at least 6 months follow-up, recovery of endocrine function was observed in all but one woman who underwent orthotopic transplantation (13 of 14 cases), in one out of two women who underwent both orthotopic and heterotopic transplantation (1 of 2 cases) and in all women who underwent heterotopic transplantation (4 of 4 cases). Women who underwent OTT to enhance fertility had no alterations in menstrual cycle and hormonal levels. In total, ten pregnancies were obtained in 25 women, resulting in four live births, two ongoing pregnancies and four spontaneous abortions.

Conclusion

Our data can help patients and physicians in their discussions and decisions about the need and possibilities of preserving fertility.
Quantifying desertification in the Qinghai Lake Basin
Authors: Wang Siqing , Ma Li , Yang Liping , Long Xinyuan , Guan Chao , Zhao Changming , Chen Ning
Published: March 2024

Desertification in the context of global change and intensified anthropogenic activities poses a huge challenge to the sustainable development of the Earth’s systems, including the Qinghai Lake Basin, which is located in the Tibetan Plateau. However, we know little about desertification in the Qinghai Lake Basin, which is an urgent and important issue. To that end, this study used the enhanced vegetation index (EVI) and the albedo data from MODIS satellites to explore this issue. Results based on vegetation cover (FVC) calculated from EVI indicated that desertification in the Qinghai Lake Basin had reversed over the last 20 years, and the heavily desertified areas were concentrated along the northwestern to northern basin boundaries and on the sandy eastern shore of Qinghai Lake. More interestingly, we found that the relationship between albedo and EVI showed a “V” shape instead of the traditional monotonic trapezoid, which may be related to multiple factors such as soil moisture, soil type, and spatial scale of sampling. This study unfolds the spatial and temporal distribution of desertification in the Qinghai Lake Basin quantitatively and emphasizes the threshold of the desertification process revealed in the EVI-albedo feature space, which sheds light on the monitoring of desertification in alpine areas.
tRNA engineering strategies for genetic code expansion
Authors: Kim YouJin , Cho Suho , Kim Joo-Chan , Park Hee-Sung
Published: March 2024

The advancement of genetic code expansion (GCE) technology is attributed to the establishment of specific aminoacyl-tRNA synthetase/tRNA pairs. While earlier improvements mainly focused on aminoacyl-tRNA synthetases, recent studies have highlighted the importance of optimizing tRNA sequences to enhance both unnatural amino acid incorporation efficiency and orthogonality. Given the crucial role of tRNAs in the translation process and their substantial impact on overall GCE efficiency, ongoing efforts are dedicated to the development of tRNA engineering techniques. This review explores diverse tRNA engineering approaches and provides illustrative examples in the context of GCE, offering insights into the user-friendly implementation of GCE technology.
Predicting infection of strawberry fruit by Mucor and Rhizopus spp. under protected conditions
Authors: Xu Xiangming , Agyare Solomon , Browne Eithne , Passey Tom
Published: March 2024

Postharvest spoilage of strawberry grown under protection, caused by Mucor spp. and Rhizopus spp., has recently become more common in the UK, but there is insufficient knowledge to develop and implement integrated management against Mucor and Rhizopus. Field sampling was conducted to obtain field data for developing models to predict the infection of Mucor and Rhizopus on strawberry fruit. Fruits were exposed to naturally occurring inoculum for a period of 24 hours before surface-sterilisation and incubation to estimate the level of infection by Mucor and Rhizopus. The observed incidence data, together with climatic conditions and inoculum trap counts, were used analysed firstly within the framework of (1) generalised linear model (GLM), and (2) classification tree. Field sampling confirmed previous research that ripening/ripe strawberry fruits are more susceptible to infection by Mucor and Rhizopus. Climatic variability, particularly in vapour pressure deficit, appears to be more important in influencing the rotting incidence of both Mucor and Rhizopus. However, the predictability of both Mucor and Rhizopus, whether as a continuous variable (incidence) in the GLM analysis or as a categorical risk in classification tree analysis, is too low to be of practical value based on those predictors used in the present study. Thus, current management may have to be based on scheduled preharvest application of alternative products to reduce infection and local pathogen inoculum as well as adopting management practice to minimise pathogen inoculum in the planting. Future research is needed to develop methods for rapid yet accurate in situ quantification of pathogen inoculum to improve disease risk predictions.
Non-adherence to anti-tuberculosis treatment and associated factors among TB patients in public health facilities of Hossana town, Southern Ethiopia, 2022
Authors: Lemma Tirore Lire , Ersido Tadele , Beyene Handiso Tilahun , Shiferaw Areba Abriham
Published: March 2024

Background

Non-adherence to anti-tuberculosis treatment is one of the crucial challenges to improving TB treatment outcomes and reducing healthcare costs. The prevalence of non-adherence to anti-tuberculosis treatment is not well documented in the study context. Therefore, this study was aimed at estimating the prevalence of non-adherence to anti-tuberculosis treatment and associated factors among TB patients attending TB clinics in Hosanna town, Southern Ethiopia, in 2022.

Methods

An institution-based cross-sectional study was conducted from April to May 2022. A systematic random sampling technique was employed to select a sample of 233 study subjects from all four public health facilities. According to the order of arrival, every second person was interviewed. Data were collected using a structured questionnaire that was created using several works of literature. A multivariable binary logistic regression analysis was used to identify factors associated with non-adherence to anti-TB drugs. The adjusted odds ratio (AOR) with a 95% confidence interval (CI) was estimated.

Results

The study included 233 tuberculosis (TB) patients with a response rate of 100%. The prevalence of non-adherence was 18% (95% CI: 15.39, 21.82). Being in the continuation phase (AOR = 3.09, 95% CI: 1.16, 8.23), not attending formal education (AOR = 2.47, 95% CI: 1.12, 5.42), not disclosing TB status to their family (AOR = 2.36, 95% CI: 0.11, 5.04) and having poor TB knowledge (AOR = 3.09, 95% CI: 1.48, 6.48) were significantly associated with non-adherence to TB treatment.

Conclusion

Among TB patients, there was a significant prevalence of non-adherence to anti-TB medications. Interventions that target patients with low education status, are in the continuation phase, and do not disclose their TB status to their families are required to improve TB treatment adherence. In addition, improving health education is important to enhance TB knowledge, which has an impact on TB treatment adherence. The need for good drug adherence should be emphasized while counseling TB patients.