bluuebunny/crossref_metadata_2025 huggingface dataset:
OPTIMALISASI PEMBUATAN BROWNIES IKAN GABUS
Authors: Fadhilah Tri Marta
Published: June 2020

Cork fish contains a lot of albumin compared to other freshwater fish, male cork fish albumin content of 6,7%, lower than female cork fish that have albumin 8,2%, are general brownies are made from flour, however, some have added fish to making brownies such as catfish and tilapia, but no one has added cork fish to make brownies, this study aims to determine to difference in sensory characteristics, the quality and content of albumin as well as the community's acceptance of brownie products. The design of this research is descriptive experimental design consisting of 2 factors: the proportion of the addition of cork fish consisting of 3 levels (60 grams, 80 grams, 100 grams), with the cork steaming process and the process without steaming cork fish. The results of this study are the average characteristics of brown, not fish-scented, not fishy and soft-textured. Brownie products that have significant differences both in terms of color, aroma, taste and texture are brownie samples with the addition of 100 grams of raw and 100 grams of steamed. The albumin content test for the addition of cork fish brownies which had the highest albumin content was found in the 100 gram raw cork fish addition brownie sample that was equal to 459.29% w / w. The results of the quality of brownie products are in accordance with SNI with the quality of water content <40% and ash content <3%. The acceptance of brownie products is that most people choose brownies with the addition of steamed cork 60 grams. The conclusion is cork fish brownies are acceptable to the public and contain high albumin.
Haze, Hunger, Hesitation: Disaster Aid after the 1783 Lakagígar Eruption
Authors: Wieners Claudia
Published: June 2020

The 1783-1784 Laki eruption was one of the most severe natural catastrophes to occur in Iceland in historical times (since 1140 years). Vegetation damage by sulphate aerosol and fluorine poisoning caused a massive decimation of livestock. The impact of fluorine poisoning and sulphate aerosol on human mortality is uncertain, but the loss of animals caused a famine which took many lives. The vulnerability of the Icelandic society to famine is discussed. 18th Century Iceland was a Danish dependency and, despite the abundance of fish in the surrounding waters, a subsistence farming community and thus highly dependent on livestock. On the other hand, the farming community possessed coping strategies which mitigated the impact of livestock loss. During the famine, the Danish government was in principle willing to provide relief. However, local authorities in Iceland were slow to ask for help, and did not dare to exploit the means at their disposal (e.g. the right to ban the export of Icelandic foodstuff) without consent from Copenhagen. The Danish officials in turn were unwilling to act decisively upon incomplete information. These two factors prevented timely measures. While 4.4 × 10^5kg of grain were provided for famine relief in summer 1784, the merchants exported 1.2 × 10^6kg of fish, which greatly aggravated the hunger in the second winter. The effects of this ‘natural’ catastrophe could therefore have been significantly reduced by efficient government.
Development of A Sport Foods Exchange List for Dietetic Practice in Sports Nutrition
Authors: Martínez-Sanz José Miguel , Menal-Puey Susana , Sospedra Isabel , Russolillo Giuseppe , Norte Aurora , Marques-Lopes Iva
Published: June 2020

Food exchange lists have been widely used in dietary practice in health and disease situations, but there are still no exchange lists for sports foods. The aim of this study was to develop a sports foods exchange list based on previously published statistical criteria. A cross-sectional study of the nutritional composition of sports foods, regarding macronutrients and energy, was carried out. A total of 323 sports foods from 18 companies were selected and divided into seven groups: sports drinks; sports gels; sports bars; sports confectionery; protein powders; protein bars; and liquid meals. A sports foods composition database based on portion size was created. Food exchange groups, with the definition of the amounts - in grams - of each sports foods within each group, were designed using the same methodology and statistical criteria as previously published. The nutritional composition of the portions usually consumed by athletes and/or recommended in commercial packaging was used to calculate the mean energy and macronutrient values for each group. Within each sports foods group, different subgroups were defined due to differences in the main and/or secondary macronutrient. The mean nutrient values of each exchange group and the subgroups were determined according to previously established rounding criteria. This sports foods exchange list, made up of commercial sports products, is a novel tool for dietetic practice. Its management will allow dietitians to adapt dietary plans more precisely to the training and/or competition of the athlete.
Measurement of Ethical Issues in Software Products
Authors: Di Tria Francesco
Published: June 2020

Ethics is a research field that is obtaining more and more attention in Computer Science due to the proliferation of artificial intelligence software, machine learning algorithms, robot agents (like chatbot), and so on. Indeed, ethics research has produced till now a set of guidelines, such as ethical codes, to be followed by people involved in Computer Science. However, a little effort has been spent for producing formal requirements to be included in the design process of software able to act ethically with users. In the paper, we investigate those issues that make a software product ethical and propose a set of metrics devoted to quantitatively evaluate if a software product can be considered ethical or not.
Breast Cancer Prediction Using Stacked GRU-LSTM-BRNN
Authors: Bandyopadhyay Samir , DUTTA SHAWNI
Published: June 2020

Breast Cancer diagnosis is one of the most studied problems in the medical domain. In the medical domain, cancer diagnosis has been studied extensively which instantiates the need of early prediction of cancer disease. For obtaining advance prediction, health records are exploited and given as input to an automated system. This paper focuses on constructing an automated system by employing deep learning based recurrent neural network models. A stacked GRU-LSTM-BRNN is proposed in this paper that accepts health records of a patient for determining possibility of being affected by breast cancer. Proposed model is compared against other baseline classifiers such as stacked Simple-RNN model, stacked LSTM-RNN model, stacked GRU-RNN model. Comparative results obtained in this study indicate that stacked GRU-LSTM-BRNN yield better classification performance for predictions related to breast cancer disease.
Understanding Livelihood Characteristics and Vulnerabilities of Small-scale Fishers in Coastal Bangladesh
Authors: Sunny Atiqur Rahman , Prodhan Shamsul H. , Ashrafuzzaman Md. , Sazzad Sharif Ahmed , Mithun Mahmudul Hasan , Haider K.M. Nadim , Alam Md Tariqul
Published: June 2020

Small-scale fishers are considered as one of the most vulnerable communities in Bangladesh but very few studies focused on the livelihood sustainability and vulnerabilities of this professional group. A fieldwork in lower Padma and upper Meghna hilsa sanctuaries identifies different livelihood characters and associated vulnerabilities of the fishers. A conceptual framework known as Sustainable Livelihood Approaches (SLA) has been introduced to analyses the qualitative and quantitative data. The insights of the livelihood strategies provide on small-scale fishers and fisheries management have been explained and explored. Fishers are found solely dependent on fishing, economically insolvent and neglected. In addition, some socio-economic abstractions such as low income, credit insolvency, lack of substitute earning flexibility make them more vulnerable. A number of effective suggestions are elicited from fishers’ perceptions, the implementation of which is crucial to ensure livelihood sustainability of the small-scale fishers.
Parameter Iklim sebagai Indikator Peringatan Dini Serangan Hama Penyakit Tanaman
Authors: Susanti Erni , Surmaini Elza , Estiningtyas Woro
Published: June 2020

Abstract. Efek negatif pemanasan global akan mempengaruhi sebagian besar organisme hidup termasuk hama penyakit tanaman. Variabel iklim seperti suhu, curah hujan, kelembaban, dan atmosfer gas akan berinteraksi dengan makhluk hidup/tanaman dengan berbagai cara dengan mekanisme yang beragam. Perubahan suhu dan konsentrasi CO2 mempengaruhi mahkluk hidup/tanaman secara langsung dalam hal jaringan dan alokasi fotosintesis organ spesifik dan secara tidak langsung melalui perubahan distribusi geografis dan dinamika populasi hama penyakit tanaman. Peningkatan suhu akan menyebabkan serangga/hama menjadi lebih berlimpah, ada kaitan kuat antara ledakan (outbreak) hama penyakit tanaman dengan variabiltas iklim. Model hubungan parameter iklim dengan serangan hama penyakit tanaman dapat digunakan sebagai teknologi adaptasi peringatan dini untuk mencegah terjadinya serangan hama penyakit tanaman, agar kehilangan hasil tanaman dapat ditekan. Konsep tulisan ini adalah pentingnya membangun peringatan dini serangan OPT berbasis model persamaan iklim dengan serangan OPT, sehingga data prediksi iklim dapat dimanfaatkan, dan kehilangan hasil akibat serangan OPT dapat ditekan. Selain itu agar sistem dapat berkembang dan berkisinambungan pembangunan sistem peringatan dini perlu integrasi beberapa instansi terkait, yaitu Kementerian Pertanian dan Universitas sebagai penyusun model prediksi dan BMKG sebagai penyedia data prediksi iklimnya.
Estimation of the Hidden Population with COVID-19 Disease
Authors: Soltanian Ali Reza , Bashirian Saeid , Basti Shahin Akhondzadeh , Karami Manoochehr , Ostovar Afshin , Khazaei Salman
Published: June 2020

The population with emerging diseases such as COVID-19, which is used to calculate the basic reproduction number of epidemic outbreak (R0) cannot be simply observed. In this article, we have proposed a method for estimating the hidden population of people with COVID-19 disease. Knowing the number of people with COVID-19 disease is very important for health policy. The provision of medical equipment (e.g., masks, alcohol, ventilators, medication, etc.), the reopening of schools and universities, the start of tourism and public gatherings, the provision of medical staff and preventive planning depend on the number of patients with the disease. Therefore, it is very important to estimate the number of patients.

Key words: • Corona virus • Covid-19 • Epidemiology • Hidden population • Attack rate

 

Copyright © 2020 Soltanian et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
PERLINDUNGAN HUKUM DIREKSI BANK BUMN TERHADAP KREDIT MACET BANK BUMN BERDASARKAN PRINSIP BUSISNES JUDGMENT RULE
Authors: Wijayanti Nova
Published: June 2020

AbstrakPeranan perbankan dalam pembangunan ekonomi suatu bangsa adalah sangat vital layaknya sebuah jantung dalam tubuh manusia. Pembangunan ekonomi oleh perbankan dilakukan dengan salah satunya melalui kredit. Pemberian kredit perbankan terutama Bank BUMN dilakukan dengan prinsip 5 C, akan tetapi sekalipun pemberian kredit bank BUMN dilakukan dengan kehati- hatian dan penerapan prinsip 5C tidak dapat dihindari kegagalan bayar oleh debitor. Kegagalan bayar ini disebut kredit macet. Kredit macet tentu merugikan bank BUMN dan Negara sebagai pemilik modal, kerugian tersebut tidak serta merta dapat disebut kerugian Negara yang berimplikasi terjadinya tindak pidana korupsi bagi manajemen bank dalam hal ini Direksi Bank BUMN. Berdasarkan Putusan MK Nomor 62/PUU-IX/2013 menegaskan bahwa kekayaan Negara pada BUMN tetap tidak dipisahkan. Akan tetapi didalam putusan MK Mahkamah Konstitusi Nomor 62 / PUU –IX / 2013 mengakui prinsip Business Judgment Rule. Business Judgment Rule ini yang menjadi dasar atau perlindungan hukum direksi Bank BUMN untuk melindungi dari kriminalisasi keputusan bisnis dalam BUMNKata Kunci : Bank BUMN, Kredit Macet, Direksi
Iniciación a los fundamentos teóricos para la educomunicación en la radio universitaria
Authors:   Universidad Miguel Hernández, Ponce López M. Carmen
Published: June 2020

La Educomunicación puede entenderse como una disciplina que abarca el estudio de dos áreas de conocimiento que tradicionalmente han estado bien diferenciadas, la Educación y la Comunicación, pero que se complementan de manera intrínseca e inevitable porque para educar hay que comunicar y cuando comunicamos, podemos estar educando. La radio universitaria surge como instrumento de formación del alumnado de los centros de enseñanza superior pero también de aproximación a la sociedad que le rodea. En este contexto, este medio de comunicación cercano y accesible para el oyente y, más concretamente, este tipo de emisora puede resultar adecuado para la educomunicación, tanto de sus estudiantes como de otros colectivos de su entorno. Este artículo pretende, a través de la revisión bibliográfica sobre el tema, recopilar, en un único documento, argumentos esgrimidos por teóricos y estudiosos para relacionar educación y comunicación y para considerar a la radio universitaria un lugar idóneo para trabajarlas de manera conjunta.
Comunicación Parlamentaria 2.0: El Debate de la Moción de Censura en Twitter
Authors:   Universidad CEU-Cardenal Herrera, Pérez Gabaldón Marta , Nicasio Varea Blanca
Published: June 2020

Los días 31 de mayo y 1 de junio de 2018 tuvo lugar la cuarta moción de censura de la historia de nuestra democracia. En esta, al igual que sucedió durante la celebrada en junio de 2017, las redes sociales van a adquirir un protagonismo en la difusión y transmisión de la información, la opinión y el análisis por parte de los principales actores involucrados, así como del conjunto de la sociedad española. Esto es así por cuanto las redes sociales son ya un instrumento consolidado en el desarrollo de la comunicación y el debate político, ya que favorecen la participación ciudadana, la comunicación instantánea y la interacción del político con los usuarios. Es por ello que la presente investigación tiene por objeto examinar los mensajes publicados en twitter tanto por los líderes de los Partidos Políticos de ámbito nacional con representación parlamentaria, como por los propios partidos. Con ello se pretende identificar, en términos cuantitativos, el impacto de los mensajes y las tendencias en la actividad de la red social durante los días del debate y, en términos cualitativos, el contenido de los mismos en base a una serie de variables preestablecidas.
Doble pantalla todo el año: Interacción en torno a las cuentas de Twitter de periodistas televisivos en México.
Authors:   Universidad Autónoma de Coahuila, Corona Antonio
Published: June 2020

El presente trabajo recuperó un año natural de actividad en torno a las cuentas personales de 20 periodistas con alta presencia televisiva en México, con la intención de esclarecer si dicha actividad se relaciona con la aparición de los periodistas en medios tradicionales, lo cual indicaría prácticas de doble pantalla como las que se han estudiado durante momentos de alta mediatización política. Se categorizó la actividad de acuerdo a horas del día, y se graficó comparativamente la distribución porcentual de la actividad de envío y recepción, teniendo en cuenta los horarios de aparición mediática de los periodistas. Se encontró que la interacción del público con los periodistas fue consecuencia de la aparición de los mismos en medios tradicionales, más que de su actividad en Twitter. Los resultados nos indican que la actividad en Twitter alrededor de los periodistas no existe en un vacío, sino que es parte de un ambiente mediático híbrido en el cual Twitter es utilizado como una herramienta de contestación de las enunciaciones en los noticieros televisivos. Se concluye que las prácticas de doble pantalla son un fenómeno de la cotidianeidad, y no sólo de momentos de alta mediatización como los debates electorales, y que esto debe reflejarse en la investigación sobre el fenómeno.
MHCJ, diez años difundiendo resultados de investigación en el ámbito de la comunicación científica
Authors:   Universidad Miguel Hernández de Elche, Jurado Martín Montserrat
Published: June 2020

Llegamos al cierre del número de julio del volumen 10 de la revista. Una década trabajando para la divulgación de los trabajos científicos de investigadores y profesores en ciernes y otros consagrados en el ámbito de la comunicación desde diferentes facetas, cinematográfica, fotográfica, especialización periodística y del entorno del mundo audiovisual. Para aquellos familiarizados con la edición de las revistas académicas universitarias, empatizarán con nosotros cuando afirmamos que nos sentimos satisfechos de nuestro esfuerzo y limitados en nuestro deseo de llegar más lejos. La competencia en la edición de revistas es grande y al mismo tiempo pocas las denominadas tops. Sentimos satisfacción por el número de artículos publicados, su calidad y variedad, pero igualmente sentimos pesar por no haber podido cumplir con nuestro anunciado monográfico especializado en radio. Sabemos que este campo de investigación es interesante, pero nuestros esfuerzos no han sido suficientes para llegar a un número mínimo de textos que conformen un monográfico, por lo que definitivamente éste no verá la luz.
Construcción de la realidad y prensa en el proceso penal
Authors:   Universidad de Córdoba (Argentina), Trimano Luciana
Published: June 2020

En la sociedad contemporánea, los medios de comunicación adquieren un papel protagónico en la construcción de conocimiento social. De aquí surge la responsabilidad que les es otorgada. La investigación emerge al observar la falta de conocimiento jurídico en los profesionales de la comunicación y en el afán por obtener nuevos saberes. A partir de reconocer la tensión existente entre Medios de Comunicación y Justicia se recorta el campo a la prensa y se indaga en los modos de construir la noticia sobre el proceso penal. En este sentido, se especifican las herramientas que utilizan los periodistas y cada una de ellas se aborda desde el análisis de contenido y la entrevista. Se trata de comprender e interpretar el significado de las prácticas periodísticas en la cultura en la que se producen. Así, se analiza ilustrativamente el caso Spedale en la ciudad de Córdoba (Argentina), por ser un juicio oral y público con la particularidad de efectuarse -al mismo tiempo- a puertas cerradas. De la aplicación de cada técnica y su análisis se elaboran las conclusiones que se presentan en este artículo.
Las dimensiones narrativas del comentario radiofónico en el magacín deportivo
Authors:   Universidad de Sevilla, Romero Bejarano Hilario José
Published: June 2020

El comentario se ha consolidado como uno de los géneros de mayor relevancia en el actual panorama radiofónico. La visión personal que imprime su autor y la capacidad que posee para albergar un amplio número de elementos y figuras expresivas lo convierten en uno de los principales referentes desde el punto de vista formal y de contenido. El magacín deportivo combina el éxito asociado a su formato de programa con la trascendencia que adquiere el deporte en la sociedad. Esta convergencia pone de manifiesto la doble dimensión informativa-espectacular de la radio deportiva, al tiempo que adquieren especial protagonismo su ubicación en la franja de la medianoche y el amplio número de géneros y registros radiofónicos diferentes que contiene. El objetivo de esta investigación es analizar los aspectos narrativos que definen al comentario deportivo en radio. Para ello se ha elaborado una muestra de 105 programas pertenecientes a las emisoras Cadena SER, COPE, Onda Cero y Abc Punto Radio. Se trata de valorar qué rol adquiere este género radiofónico en la programación deportiva, y de comparar su identidad como modelo de representación con respecto a los comentarios emitidos en los programas informativos de actualidad y que ya han sido estudiados previamente dentro de la comunidad científica. Los resultados obtenidos permitirán determinar el nivel de homogeneidad existente y las nuevas tendencias estéticas de la radio española.
Pluralismo informativo, injerencia política y representación ideológica en el programa Informe Semanal de RTVE
Authors:   Universidad Rey Juan Carlos (URJC), Muñoz Guerrero Daniel
Published: June 2020

En abril de 2012 se aprueba el Real Decreto-ley 15/2012 que modifica el régimen de administración de la Corporación RTVE y que permite al Gobierno designar sin consenso político al Presidente de la televisión pública española. Este cambio legislativo permite al partido en el Gobierno nombrar a Leopoldo González-Echenique presidente de RTVE. A los pocos meses González-Echenique sustituye al director de los Servicios Informativos de TVE Fran Llorente por Julio Somoano, y comienza a destituir a numerosos profesionales de reconocida trayectoria periodística para conformar un nuevo equipo. Pronto los índices de audiencia comienzan a descender y la oposición política, el Consejo de Informativos de TVE y el Consejo de Europa denuncian a la nueva dirección de la entidad pública por manipular ideológicamente los contenidos informativos. El objetivo de la presente investigación consiste en comprobar mediante el análisis científico de las emisiones del programa Informe Semanal si existen evidencias significativas de que el Gobierno, tras el cambio de dirección de TVE, influye ideológicamente en los contenidos informativos. Para completar el análisis estudiamos las sesiones de la Comisión Mixta de Control Parlamentario de la Corporación RTVE y sus Sociedades, los índices de audiencia y el cumplimiento de los principales mecanismos de autorregulación del ente público. Finalmente ofrecemos una serie de recomendaciones para aumentar el grado de independencia política de los Servicios Informativos de TVE.
Tratamiento de las noticias de Valencia en la prensa gratuita
Authors: Gironés Bolinches Ana
Published: June 2020

La prensa gratuita de periodicidad diaria, tal y como la conocemos en la actualidad, es un fenómeno social poco estudiado y relativamente ‘nuevo’ en España, especialmente en Valencia. El principal objetivo del presente trabajo es conocer qué importancia y qué peso tienen las noticias valencianas (noticias locales) en la prensa gratuita que se reparte en la ciudad. Paraello se han utilizado tres métodos de investigación: entrevistas y encuestas; análisis de contenido y la observación participante. Para conocer el tratamiento que reciben las noticias valencianas se ha seguido "el análisis de contenido" y la clasificación de Bardin en el que se tienen en cuenta unas variables previamente definidas como: el número de noticias locales frente a las noticias nacionales e internacionales, su ubicación, extensión, si lleva o no foto, etcétera. Es decir, si realmente las noticias de Valencia son una parte importante del periódico o simplemente son un pretexto para conseguir publicidad regional y local. Es decir, si el motivo o transfondo es informativo o puramente económico. Los resultados obtenidos demuestran que el peso de la información valenciana es escaso no sólo en número, desde el punto de vista de la cantidad, sino también desde el punto de vista de la calidad, por el tratamiento que reciben las noticias de Valencia. Se puede decir que el principal objetivo de los gratuitos es más comercial que informativo. Las empresas lanzan a la calle un producto "informativo" como pretexto para conseguir publicidad local y entrar en las grandes campañas nacionales justificando que su periódico se reparte en las principales ciudades españolas. El periodo de estudio es de 2007, año de mayor proliferación de gratuitos en Valencia (20 Minutos, Qué!, Metro, ADN y Mini Diario) a 2009 y su comparación con 2014. El objeto a estudiar en el presente trabajo es por una parte innovador, ya que se trata de un fenómeno social relativamente nuevo y poco estudiado. Pero ello entraña también una dificultad y es la escasa bibliografía existente.
Análisis sobre el uso de Twitter en las administraciones locales de la provincia de Castellón
Authors:   Universitat Jaume I de Castelló, Pardo Baldeón Ramón Serafín
Published: June 2020

El importante impacto del uso de las tecnologías digitales en las relaciones sociales, y en especial de las redes sociales, hace que políticos y administraciones estén presentes en ellas. La aparición de la web 2.0 facilita el acceso de los ciudadanos a la gestión de la administración y permite la interactuación, algo que convierte a estas redes en plataformas de comunicación política que cambian el concepto de espacio público y cuestionan la hegemonía de los medios tradicionales sobre la información. Por ello, desde 2011, los gabinetes de comunicación de la Diputación de Castellón y de los ayuntamientos con mayor peso socioeconómico de la provincia han pasado de compatibilizar la emisión de comunicados en la web institucional a crear perfiles corporativos en las redes sociales, en especial en Twiter. Este trabajo tiene como objeto de estudio el análisis de la evolución y cambios de la estrategia relacional de los gabinetes de comunicación para acercarse a los ciudadanos y recuperar su confianza. Se hace a partir de la consulta de datos secundarios como la emisión de comunicados de prensa desde 2011 hasta 2013 y del análisis de los mensajes institucionales en Twiter con las herramientas Metricspot y Brandtweet. Se constata el aumento de información institucional en sus websites y redes sociales sin apenas opciones al dialogo público con los ciudadanos.
Vaccine Design against Coronavirus Spike (S) Glycoprotein in Chicken: Immunoinformatic and Computational Approaches
Authors: Awadelkareem Eman Ali , Ali Sumaia Awad Elkariem
Published: June 2020

Background: Infectious bronchitis (IB) is a highly contagious respiratory disease in chickens and produces economic loss within the poultry industry. This disease is caused by a single stranded RNA virus belonging to Cronaviridae family. This study aimed to design a potential multi-epitopes vaccine against Infectious bronchitis virus spike protein (S). Protein characterization was also performed for IBV spike protein.Methods: The present study used various tools in Immune Epitope Database (IEDB) to predict conserved B and T cell epitopes against IBV spike (S) protein that may perform a significant role in provoking the resistance response to IBV infection. Results: In B cell prediction methods, three epitopes (1139KKSSYY1144, 1140KSSYYT1145, 1141SSYYT1145) were selected as surface, linear and antigenic epitopes. Many MHCI and MHCII epitopes were predicted for IBV S protein. Among them 982YYITARDMY990 and 983YITARDMYM991 epitopes displayed high antigenicity, no allergenicity and no toxicity as well as great linkage with MHCI and MHCII alleles. Moreover, docking analysis of MHCI epitope produced strong binding affinity with BF2 alleles. Conclusion: Five conserved epitopes were expected from spike glycoprotein of IBV as the best B and T cell epitopes due to high antigenicity, no allergenicity and no toxicity. In addition, MHC epitopes showed great linkage with MHC alleles as well as strong interaction with BF2 alleles. These epitopes should be designed and incorporated and then tested as multi-epitope vaccine against IBV.
Simulation in Physiotherapy Students for Clinical Decisions During Interaction with People with Low Back Pain. Randomized Controlled Trial
Authors: Sandoval-Cuellar Carolina , Acosta-Otalora Martha Lucia , Villarraga-Nieto Angélica del Pilar , Goyeneche-Ortegón Ruth Liliana , Castellanos-Garrido Adriana Lucia , Castellanos-Vega Rocio del Pilar , Cobo-Mejía Elisa Andrea , Alfonso-Mora Margareth Lorena
Published: June 2020

Background: Low back pain (LBP) is a symptomatology with a high global prevalence; health professionals, including physiotherapists, must have the skills to create professional interaction plans that permit a better quality of life for consultants. Clinical simulation can be a pedagogic setting that facilitates in students adequate training to acquire skills that improve professional reasoning in this clinical situation. The objective of this study was to compare the effects of clinical simulation with simulated patient (SP) versus simulation with role playing (RP) in physiotherapy students for decision-making in clinical skills while caring for a person with LBP. Methods. Experimental study, with 42 participants from two Colombian universities, randomized into two groups (SP n = 21, RP n = 21). The clinical skill was evaluated during the interaction with a person with LBP for which the Objective Structured Clinical Examination (OSCE-ML) was validated for individuals with low back pain; thereafter, a pedagogical method was conducted that included clinical simulation and, finally, the OSCE-ML was applied again to compare both groups. Results. Changes occurred in the OSCE-ML among both groups of students: the scores increased (0.66 and 0.59 in RP and SP, respectively), and neither of the two was superior (difference 0.01 95%CI -0.21 to 0.23). Conclusion. Both types of simulation favour decision-making in professional reasoning in physiotherapy students during interaction with individuals with LBP. Trial Registration: https://clinicaltrials.gov/ct2/show/NCT04428892 Identifying number: NCT04428892. Retrospectively registered.
Confirmed or Unconfirmed Cases of 2019 Novel Coronavirus Pneumonia in Italian Patients: A Retrospective Analysis of Clinical Features
Authors: De Angelis Giulia , Posteraro Brunella , Biscetti Federico , Ianiro Gianluca , Verme Lorenzo Zileri Dal , Cattani Paola , Franceschi Francesco , Sanguinetti Maurizio , Gasbarrini Antonio
Published: June 2020

This study was aimed to compare clinical features of 165 Italian patients with laboratory confirmed or unconfirmed 2019-nCoV (also termed SARS-CoV-2) pneumonia. On March 31 2020, hospitalized patients who presented with fever and/or respiratory symptoms, exposures, and presence of lung imaging features consistent with 2019-nCoV pneumonia, were included. Before admission to a hospital ward, patients underwent RT-PCR based SARS-CoV-2 RNA detection in their nasopharyngeal swab samples. Of 165 patients studied, 119 had positive RT-PCR results and 46 were RT-PCR negative for two days or longer (i.e., when the last swab sample was obtained). The median age was 70 years (IQR, 58–78), and 123 (74.6%) of 165 patients had at least one comorbidity. The majority of patients (101/165, 61.2%) had a mild pneumonia, and the remaining patients (64/165, 38.8%) a severe/critical pneumonia. We did not find any substantial difference in symptoms, incubation periods, and radiographic/CT abnormalities as well as in many of the biological abnormalities recorded. However, at multivariable analysis, higher concentrations of hemoglobin (OR, 1.34; 95% CI, 1.11‒1.65; P = 0.003) and lactate dehydrogenase (OR, 1.00; 95% CI, 0.99‒1.01; P = 0.05), and lower counts of leukocytes (OR, 0.81; 95% CI, 0.72‒0.90; P <0.001) were independently associated with confirmed COVID-19 diagnosis. While mortality rates were similar, patients with confirmed diagnosis were more likely to receive antivirals (95% vs 19.6%, P <0.001) and to develop ARDS (63% vs 37%, P = 0.003) than those with unconfirmed COVID-19 diagnosis. In conclusion, our findings suggest that unconfirmed 2019-nCoV pneumonia cases may be actually COVID-19 cases and that clinicians should be cautious when managing patients with presentations compatible with COVID-19.
Establishment of an immune-related gene pairs model to predict colon adenocarcinoma prognosis
Authors: Luo Jihang , Liu Puyu , Wang Leibo , Huang Yi , Wang Yuanyan , Geng Wenjing , Chen Duo , Bai Yuju , Yang Ze
Published: June 2020

Background. Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma(COAD) is the main pathological type of colon cancer. There is a lot of evidence describing the correlation between the prognosis of COAD and the immune system. The objective of the current study was the development of a robust prognostic immune-related gene pairs (IRGPs) model for estimating overall survival of COAD. Methods. The gene expression profiles and clinical information of patients with colon adenocarcinoma come from TCGA and GEO databases and are divided into training and validation cohorts. Immune genes were selected which show significantly association with prognosis. Results. Among 1647 immune genes, a 17 IRGPs model was built which was significantly associated with OS in the training cohort. In the training and validation data set, the IRGPs model divided patients into high-risk groups and low-risk groups, and the prognosis of the high-risk group was significantly worse(P＜0.001). Univariate and multivariate Cox proportional hazard analysis confirmed the feasibility of this model. Functional analysis confirmed that multiple tumor progression and stem cell growth-related pathways in high-risk groups were up-regulated. T cells regulatory and Macrophage M0 were significantly highly expressed in the high-risk group. Conclusion. We successfully constructed an IRGPs model that can predict the prognosis of COAD, which provides new insights into the treatment strategy of COAD.
Unveiling the SEI Formation in a Potassium Ion Battery Using Distribution of Relaxation Time
Authors: Chen Yuhui , Sheng Chuanchao , Yu Fengjiao , Li Chunmei , Zhang Heng , Huang Jun , Wu Yuping , Armand Michel
Published: June 2020

Understanding of solid electrolyte interphase (SEI) formation process in novel battery systems is of primary importance. Alongside increasing powerful in-situ techniques, searching for readily-accessible, non-invasive, and low-cost tools to probe battery chemistry is highly demanded. Here, we applied distribution of relaxation time (DRT) analysis to interpret in-situ electrochemical impedance spectroscopy results during cycling, which is able to distinguish various electrochemical processes based on their time constants. By building direct link between SEI layer and the cell performances, it allows us track the formation and evolution process of SEI layer, diagnose the failure of cell, and unveil the reaction mechanism. For instance, in a K-ion cell using SnS2/N-doped reduced graphene oxide (N-rGO) composite electrode, we found that the ion-transport in the electrolyte phase is the main reason of cell deterioration. In the electrolyte with potassium bis(fluorosulfonyl)imide (KFSI), the porous structure of the composite electrode was reinforced by rapid formation of a robust SEI layer at SnS2/electrolyte interface and thus the KFSI-based cell delivers a high capacity and good cycleability. This method lowers the barrier of in-situ EIS analysis, and helps public researchers to explore high-performance electrode materials.
Molten Carbonate Fuel Cell Power Generation Technology and its Challenges
Authors: Li Hao , Zhang Ruiyun , Lu Chengzhuang , Cheng Jian , Xu Shisen , Yang Guanjun , Huang Hua
Published: June 2020

As a clean and efficient power generation device, molten carbonate fuel cell(MCFC)can directly convert chemical energy into electrical energy at the operating temperature of 650 degrees, avoiding the heat loss caused by the Carnot cycle, and effectively reducing the emission of CO2 and other pollutants. This paper introduces the background, basic principle, system design and current situation of fused carbonate fuel cell at home and abroad, and explains the technical problems that molten carbonate power generation technology is facing. At the same time, the cost of the molten carbonate power generation system is analyzed, and the present cost and the cost after industrialization are compared and evaluated to provide a reference for the economy of the molten carbonate fuel cell power generation system.
The Waveform Inversion of Mainshock and Aftershock Data of the 2006 M6.3 Yogyakarta Earthquake
Authors: Saputra Hijrah , Wahyudi Wahyudi , Suardi Iman , Suryanto Wiwit
Published: June 2020

This research was examines the focal mechanism associated with the mainshock and three aftershocks of the magnitude 6.3 Yogyakarta earthquake on May 27, 2006. This study, therefore, aims to provide a cleareranswer on the source mechanism of the earthquake, which has been debated. Data were obtained from the mainshock and aftershock sources, on June 8, 9, and 16, 2006. The mainshock and three aftershocks were used to conduct waveform inversion by calculating the Green's functions through the extended reflectivity method of the near-field and the far-field signal component. The mainshock's focal mechanism has a strike, dip, and range angle of 243.40o, 77.50o, and -28.30o, respectively.Furthermore, the mainshock is not a pure strike-slip as previously hypothesized. The focal mechanism for the aftershock earthquake source on Mw 4.4, obtained on June 8, had a strike, dip, rake, and variance of 192.20o, 29.70o, -48.30o and 0.22, respectively. This aftershock had a different segment from the mainshock event and those obtained on the 9 and 16 of June with the same type of faulting as the mainshock with variance values of 0.195 and 0.243. These results showed that the mainshock of May 27, 2006, activated the aftershock on June 8, with a different type of fault.
A Phase 2 Study of Combined Chemo-Immunotherapy with Cisplatin-Pembrolizumab and Radiation for Unresectable Vulvar Squamous Cell Carcinoma
Authors: Yeku Oladapo , Russo Andrea L , Lee Hang , Spriggs David
Published: June 2020

Purpose: Unresectable or metastatic vulva cancer has relatively poor outcomes despite chemotherapy-sensitized radiation therapy and combination cytotoxic therapy. Despite the virus-associated and immunogenic nature of this disease, novel immunotherapy options that exploit this advantage are currently lacking. Platinum agents such as cisplatin have been shown to prime dendritic cells for T-cell costimulation, promote downregulation of inhibitory checkpoint molecules, and sensitize tumor cells to cytotoxic T-cell killing. Radiation therapy has also been shown to promote immunogenetic cell death as monotherapy and in combination with cisplatin. In combination with pembrolizumab, cisplatin-sensitized radiation is hypothesized to increase overall response rates and recurrence-free survival in patients with vulva cancer, via induction of an anti-tumor inflammatory response.Methods: We propose a single-arm phase II clinical trial of pembrolizumab combined with cisplatin-sensitized radiation therapy for women with unresectable, locally advanced, or metastatic vulva cancer. The first three patients with locally advanced or unresectable disease will receive cycle 1 of pembrolizumab followed by a break and resumption of pembrolizumab at cycle 4 and as part of a safety cohort. All other patients, including the fourth patient with locally advanced/unresectable disease, will receive weekly cisplatin and pembrolizumab every 3 weeks, concurrently with daily radiation therapy. Following the completion of Cis-RT, patients will continue pembrolizumab maintenance for a total of 12 cycles. Archived tissue will be used for HPV status, MSI status, PD-L1, and TIL stratification post-hoc. Imaging will be performed at baseline and every 3 cycles (21-day cycles) as per standard-of-care. Laboratory analysis will occur on the first day of each cycle. Discussion: The combination of cisplatin-sensitized radiation and immune checkpoint blockade has not been evaluated in the upfront setting for vulvar cancer. In this rare malignancy, there are limited interventional clinical trials. This trial is designed to be as accessible as possible by allowing patients to receive cisplatin and radiation locally according to accepted standard-of-care while receiving pembrolizumab and adverse event monitoring at a centralized site. A robust suite of translational correlative studies has also been built into the trial to evaluate tumor-directed immune activation. Trial registration: NCT04430699
Coronavirus Pandemic: Opportunities or Challenges for Energy Transition?
Authors: Cui Lianbiao , Zhang Xiaobing , Duan Hongbo , Zhu Lei
Published: June 2020

The coronavirus pandemic greatly shocked the global energy market, which could be clearly demonstrated by the recent collapse in crude oil prices. Using a dynamic multi-regional computable general equilibrium model, we explored the influences of the COVID-19 pandemic on energy production and consumption. The associated impacts on the macroeconomy as well as on carbon emissions are also examined. The results of this paper indicate dramatic negative shocks of the COVID-19 pandemic to energy consumption at both global and national levels, particularly for oil and oil products. However, the energy transition to renewables will be paused, as other non-oil fossil fuels can still play significant roles in economic activity. The epidemic may also temporarily terminate the more than ten-year increasing trend of the world’s total CO2 emissions, despite its limited contribution to the mitigation of global warming. However, there are still many opportunities worthy of use to promote short- or mid-term low-carbon energy transitions.
Advantage of pars plana vitrectomy combined with penetrating keratoplasty and transscleral-sutured intraocular lens implantation in complex eyes: a case series
Authors: Hayashi Takahiko , Ida Yasutsugu , Shimizu Toshiki , Kuroki Tsubasa , Kobashigawa Yuji , Iijima Yasuhito , Yuda Kentaro
Published: June 2020

Background The aim of this study was to evaluate the clinical outcomes of pars plana vitrectomy (PPV) combined with penetrating keratoplasty (PKP) and transscleral-sutured intraocular lens (IOL) implantation (IOL-suture) in complex eyes.

Methods In this prospective, consecutive interventional case series, patients who underwent PKP combined with PPV and IOL implantation from July 2014 to Mar 2017 at Yokohama Minami Kyosai Hospital were enrolled. The postoperative best corrected visual acuity (BCVA) (converted to logarithm of the minimal angle of resolution [logMAR] units), intraocular pressure (IOP, mmHg), endothelial cell density (ECD, cells/mm2), graft survival, complications, astigmatism, and spherical equivalent (dioptres [D]) were evaluated.

Results This study included 11 eyes of 11 patients (three females and eight males; mean age, 61.8 ± 13.9 years) with an injury (n = 6) or bullous keratopathy (n = 5). The BCVA significantly improved from 1.50 ± 0.66 logMAR preoperatively to 0.78 ± 0.59 logMAR (p < 0.001) postoperatively. The baseline ECD significantly decreased from 2396 ± 238 cells/mm2 preoperatively to 1132 ± 323 cells/mm2 (p < 0.001) postoperatively. Despite two rejection episodes, graft survival rates were 100%. The mean follow-up period was 38.0 ± 20.5 months. Two patients required combined glaucoma surgery, and three patients underwent subsequent glaucoma surgery. Postoperative astigmatism and the spherical equivalent were 3.9 ± 3.2 D and 0.29 ± 2.18 D, respectively.

Conclusion The combination of PKP, PPV, and IOL-suture implantation could be a safe and effective approach for eyes requiring anterior segment surgery; however, these eyes are associated with a higher incidence of glaucoma surgery.
Musculo-skeletal phenotype of Costello syndrome and cardio-facio-cutaneous syndrome: insights on the functional assessment status
Authors: Leoni Chiara , Romeo Domenico M , Michele Pelliccioni , Mariangela Di Già , Roberta Onesimo , Valentina Giorgio , Elisabetta Flex , Tartaglia Marco , Rigante Donato , Valassina Antonio , Zampino Giuseppe
Published: June 2020

BackgroundCostello syndrome (CS) and cardio-facio-cutaneous syndrome (CFCS) belong to the RASopathies, a group of neurodevelopmental disorders with skeletal anomalies as associated features. Due to their rarity, the characterization of the musculo-skeletal phenotype in both CS and CFCS has been poorly characterized compared to other RASopathies. Patients and methodsHerein we assessed a thorough evaluation of orthopedic findings in CS and CFCS in a monocentric cohort of patients, including information about their functional status. A total of 34 patients with molecularly confirmed diagnosis of CS (N=17) and CFCS (N=17) were recruited. Data on orthopedic findings were collected by filling in a comprehensive checklist of 100 items assessment. Functional and disability evaluations were performed by assessing the 6-minute walking test (6MWT) in patients with independent walking and Pediatric Outcomes Data Collection Instrument (PODCI). Genotype/phenotype correlations were assessed taking into account available data in the literature. ResultsOrthopedic manifestations are highly prevalent in CS and CFCS, and do overlap in the two disorders. Overall, patients with CS harboring the recurrent HRAS Gly12Ser substitution show a more severe skeletal phenotype compared to patients carrying the Gly12Ala and Gly13Cys variants. Among CFCS patients, those with MAP2K1/2 mutations show different skeletal characteristics compared to BRAF variants, with a higher prevalence of orthopedic abnormalities. Generalized muscular hypotrophy is detected in most recruited patients. Functional assessment demonstrates that patients with CS and CFCS reach lower values compared to the general population with CFCS patients showing the lowest scores.ConclusionsOrthopedic manifestations appear universal features of CS and CFCS and they can evolve along patients’ life. Longitudinal assessment of disability status by using 6MWT and PODCI could be useful to evaluate the functional impact of orthopedic and neurological manifestations on patients’ outcome, and help monitoring planning a tailored treatment of these comorbidities.
The Inhibitor of DNA Binding Family Regulates the Prognosis of Ovarian Cancer
Authors: Zhou Quan , Mei Ye-dong Mei , Huai-jie Yang , Ya-ling Tao
Published: June 2020

Background: The inhibitor of DNA binding or differentiation (ID) protein family contributes to the carcinogenesis and progression of various cancers. However, its mechanistic role in tumor initiation and progression of ovarian cancer (OC) has remained unclear. Methods: We used the Oncomine, GEPIA, Kaplan-Meier plotter, cBioPortal, SurvExpress, PROGgene V2 server, TIMERdatabase, and FunRich to evaluate the expression and predictive prognostic value of individual IDs members’ mRNA in patients with OC. Results: Our results revealed that the mRNA transcripts of all ID family members were markedly downregulated in OC compared to normal tissue. Aberrant expression of ID 1/3/4correlated with cancer aggressiveness and clinical in OC patients. The prognostic value of ID members was also explored within the subtypes, pathological stages, clinical stages, and TP53 mutational status. The group with a low risk IDs showed a relatively good overall survival (OS) in comparison to the high-risk group. In contrast, the expression level of IDs was significantly associated with the levels of inﬁltrating B cells and macrophages. Finally, enrichment analysis showed that ID co-expressed genes were involved in ID-, c-MYC, TNF-, and Wnt signaling pathways. Conclusion: These results indicate that ID1/3/4 may be exploited as promising prognostic biomarkers and therapeutic targets in OC patients.