bluuebunny/crossref_metadata_2025 huggingface dataset:
Digital transformation of the Russian media business in the face of uncertainty
Authors: Druzhinin A. M.
Published: January 2022

The article is of a theoretical nature, and all reasoning is based on qualitative research methods on the controversial issues of the digital transformation of the domestic media business. The conditions of uncertainty, within which the decision-makers in this socio-economic sphere of activity act today, are the key feature of digital transformation process. The reasons, impeding the implementation of innovations in the media industry, have been analysed. The factors, under which the organisation avoids risky experiments in management of media production, have been highlighted.

It has been concluded that modern media players have to adapt to changing environmental conditions faster than their competitors, and the adaptation process is the basis for developing a competitive advantage in the market. Platforms, technologies and algorithms are implemented into media production, in no small part, in the context of an understanding of the infosphere and technosphere processes within the framework of actor-network theory. They perform work on an equal level with the subjects. This process introduces significant amendments to the structures, business processes, and financial models of the media industry. Finding ways to make the best changes is a key dilemma for media organisations. On the one hand, it is beneficial for them to exploit existing capabilities, resources, and competencies. On the other hand, renewal and adaptation are dictated by such organisations by the external environment, while simultaneously increasing costs and risks.
Coadsorption of NRR and HER intermediates determines the performance of Ru-N4 towards electrocatalytic N2 reduction
Authors: Wu Tongwei , Melander Marko , Honkala Karoliina
Published: January 2022

Electrochemical N2 reduction (NRR) to ammonia is seriously limited by the competing hydrogen evolution reaction (HER) but atomic-scale factors controlling HER/NRR competition are unknown. Herein we unveil the mechanism, thermodynamics, and kinetics determining the HER/NRR efficiency on the state-of-the-art NRR electrocatalyst, Ru-N4, using grand canonical ensemble density functional theory (GCE-DFT). We show that NRR/HER intermediates coadsorb on the catalyst where NRR intermediates suppress HER and selectivity is determined by the initial step forming *NNH or *H. Our results provide crucial insight into the complex NRR/HER competition, show the necessity of using GCE-DFT calculations, and suggest ways to improve NRR selectivity.
Women in science: Towards a copper-azophloxine inorganic complex for the selective naked-eye detection of pyrophosphate in water
Authors: Rossel Thibaud , Bieri Aria
Published: January 2022

Indicator displacement assay is a well-known methodology reported for the detection of analytes. It is very easy to perform, especially with high school students. Since the methodology is simple, wide libraries can be generated with such a strategy. Potentially, it could provide interesting chemosensors never reported in the literature for the naked-eye detection of a specific analyte of interest. Here for a maturity work, we investigated the possibility to detect pyrophosphate with an indicator displacement assay. In first instance, we combined copper with azophloxine to form an inorganic complex in water. The chemosensor is not reported in the literature and is able to detect pyrophosphate at micromolar concentration with a concomitant color change. In second instance, we screened a collection of anions in order to investigate the selectivity of our chemosensor. Our results showed that our sensor is very specific to pyrophosphate and doesn’t suffer from interactions with phosphate or carbonate. Taken together our results indicates that real research with socially relevant results can be conducted at high school by using smart methodologies and very modest resources.
Visible-light enabled C(sp3)–C(sp2) cross-electrophile coupling via synergistic nickel and halogen-atom transfer (XAT) catalysis
Authors: Yedase Girish Suresh , Jha Avishek Kumar , Yatham Veera Reddy
Published: January 2022

We herein report the first visible-light-mediated cross-coupling of unactivated alkyl iodides with aryl bromides through synergistic nickel and halogen atom transfer (XAT) catalysis. This simple protocol operates under mild reaction conditions and tolerates variety of functional groups affording C(sp3)–C(sp2) cross-coupling products in good to moderate yields.
Revealing the Influence of Diverse Secondary Metal Cations on Redox-Active Palladium Complexes
Authors: Golwankar Riddhi , Kumar Amit , Day Victor , Blakemore James
Published: January 2022

Incorporation of redox-inactive metals into redox-active complexes and catalysts attracts attention for engendering new reactivity modes, but this strategy has not been extensively investigated beyond the first-row of the transition metals. Here, the isolation and characterization of the first series of heterobimetallic complexes of palladium with mono-, di-, and tri-valent redox-inactive metal ions are reported. A Reinhoudt-type heteroditopic ligand with a salen-derived [N2,O2] binding site for Pd and a crown-ether-derived [O6] site has been used to prepare isolable adducts of the Lewis acidic redox-inactive metal ions (Mn+). Comprehensive data from single-crystal X-ray diffraction analysis reveal distinctive trends in the structural properties of the heterobimetallic species, including an uncommon dependence of the Pd•••M distance on Lewis acidity. The reorganization energy associated with reduction of the heterobimetallic species is strongly modulated by Lewis acidity, with the slowest heterogeneous electron transfer kinetics associated with the strongest incorporated Lewis acids. This hitherto unexplored reorganization energy penalty for electron transfer contrasts with prior thermodynamic studies, revealing that kinetic parameters should be considered in studies of reactivity involving heterobimetallic species.
Bioinspired Asymmetric Total Synthesis of Emeriones A–C
Authors: Jänner Sven , Isak Daniel , Miller Aubry
Published: January 2022

We report an asymmetric bioinspired total synthesis of the fungal metabolites emeriones A–C via stereoselective late-stage epoxidation or endoperoxidation of two bicyclo[4.2.0]octadiene diastereomers. The central bicyclic scaffold is synthesized in an 8pi/6pi electrocyclization cascade of a stereodefined (E,E,Z,Z,E)-pentaene, which contains the fully assembled and unprotected side chains of the natural products. The pentaene is constructed convergently through Stille cross-coupling of two similarly complex polyenes. The anti-aldol side chain of the emeriones is made using a Paterson-aldol approach, and the epoxide of the dioxobicyclo[3.1.0] side chain is synthesized via an unusual ring-closure onto an oxidized para-methoxyphenyl acetal. Our total synthesis has enabled the revision of the structure of emerione C and the synthesis of a “missing” family member, which we hereby call emerione D.
Decorating beads with paramagnetic rings: synthesis of inorganic-organic [10^14]rotaxanes as shown by spin counting
Authors: Asthana Deepak , Thomas Dean , Lockyer Selena J. , Brookfield Adam , Timco Grigore A. , Vitorica-Yrezabal Iñigo J. , Whitehead George F. S. , McInnes Eric J. L. , Collison David , Leigh David A. , Winpenny Richard E.P.
Published: January 2022

Polymer beads have been used as the core of magnetic particles for around twenty years. Here we report studies to attach polymetallic complexes to polymer beads for the first time, producing beads of around 115 microns that are attached to 10^14 hybrid inorganic-organic [2]rotaxanes. The bead is then formally a [10^14] rotaxane. The number of complexes attached is counted by including TEMPO radicals within the thread of the hybrid [2]rotaxanes, and then performing spin-counting using EPR spectroscopy.
Energetic Competition in the Complexation Affinity of Paracetamol with Water and Oxalic Acid
Authors: Studinger Amanda , Valenzano-Slough Loredana
Published: January 2022

The intermolecular interactions of active pharmaceutical ingredients (APIs) are the driving forces of API molecular activity in solid crystal structure and stability, in vivo receptor binding, and in environmental transport and persistence. In API manufacturing, complexation of the API with another molecule (cocrystal conformer) to create stable crystalline structures can be a useful tool, but the possibility of more energetically stable complexes forming instead of the target conformation can lead to undesired changes to the properties of the final product. Natural complexation of the API to cocrystal conformers in the environment can cause undesirable accumulation of the API. Using Density Functional Theory (DFT), the paracetamol and oxalic acid (PCA-OXA) cocrystal was studied to determine how hydrogen bonding dictates complex formation. Five different functionals were employed: B3LYP-D3, B3LYP-D3-BJ, M06-2X, M06-2X-D3, and B97-XD in combination with the aug-cc-pVDZ Dunning basis set. The hydrogen bonding sites of PCA-OXA were investigated to determine strength and overall contribution/competition of H-bonding formation during the initial stages of the nucleation process by relaxing the geometries and evaluating structural and energetic changes. Complexation and configuration energies were calculated for 1:1 PCA-OXA, PCA-Water, and OXA-Water complexes. Calculations were performed both in vacuum and in water environment (explicit and implicit solvation). Results showed significant shortening of the hydrogen bonds within the PCA-OXA complex with large changes in energy during complexation of oxalic acid with paracetamol. An overall analysis of all of the results collected for the PCA-OXA complexes indicates that sites 2 and 4 play the largest roles in the initial steps of the nucleation process with position 2 showing the most stable intermolecular interactions. It is expected that in an aqueous environment, there would be little to no energetic competition for PCA to form hydrogen bonds with other molecules.
CAUCASUS - BLACK SEA - CRIMEA PRACTICE: HISTORY, ORGANISATION, EXPERIENCE
Authors: Дорофеев Александр Александрович
Published: January 2022

В статье описаны история, опыт проведения комплексных дальних практик по географии и туризму студентов факультета Географии и Геоэкологии ТвГУ на территории Западного Кавказа, Крыма и российского Причерноморья. Раскрыты главные методические особенности организации практик. Указан состав участников, названы факторы, способствовавшие практикам, описаны логистика, маршруты и посещаемые объекты. Отмечены люди, помогавшие проведению практик.

The article gives history, experience of conducting comprehensive long-distance practices on geography and tourism with the students of the faculty of Geography and Geoecology of TSU on the territory of West Caucasus, Crimea and Russian Black Sea region. The main methodological features of the organization of practices are revealed. The list of participants is indicated, the factors contributing to the practices are named, logistics, routes and visited objects are described. People who helped to conduct practices are named.
CHANGES IN AIR TEMPERATURE AND THE QUANTITY OF PRECIPITATION IN THE TERRITORY OF THE CENTRAL FOREST STATE NATURAL BIOSPHERE RESERVE IN THE LAST 30 YEARS
Authors: Сергеев Антон Романович , Прокофьева Наталья Борисовна
Published: January 2022

Цель исследования - выявить климатические тенденции, возникающие в условиях минимального антропогенного влияния в пределах заповедной территории. Научная новизна исследования - в выборе «чистой» природоохранной территории, для которой выполнен анализ динамики температуры воздуха и количества осадков за многолетний и среднесезонный периоды.

The purpose of the study is to identify climatic trends that arise under conditions of minimal anthropogenic influence within the protected area. The scientific novelty of the research lies in the choice of a “clean” nature conservation area, for which the analysis of the dynamics of air temperature and precipitation amount for long-term and mid-season periods has been carried out.
TO THE 80TH ANNIVERSARY OF THE LIBERATION OF KALININ. RECOGNITION OF THE DEAD 81 SOLDIERS 243 SD ACCORDING TO THE SPATIO-TEMPORAL DATA OF ARCHIVAL DOCUMENTS
Authors: Щекотилов Владимир Геннадьевич , Лазарев Олег Евгеньевич , Шалаева Мария Владимировна , Щекотилова Светлана Николаевна
Published: January 2022

Представлены результаты практической апробации предложенной методики подготовки обоснования для признания погибшими воинов, пропавших без вести. Методика основывается на использовании ГИС с архивными и современными картами, а также архивных материалов из базы данных системы «Память народа» и Центрального архива Министерства обороны. Около четверти из общего числа воинов, признанных погибшими, воевала в 243 сд[54], которая вела оборонительные и наступательные бои в 1941-1942 гг. в районе г. Ржев и г. Калинин.

The results of the practical approbation of the proposed methodology for the preparation of a justification for the recognition of dead missing soldiers are presented. The methodology is based on the use of GIS with archival and modern maps, as well as archival materials from the database of the system "Memory of the People" and the Central Archive of the Ministry of Defense. About a quarter of the soldiers recognized as dead fought in 243 sd, which conducted defensive and offensive battles in 1941-1942 in the area of Rzhev and Kalinin.
Challenges in Music Education from the Aspect of Inclusion of Student with Visual Impairments / Izzivi glasbenega izobraževanja z vidika slabovidnega učenca
Authors: Cvrtila Tomislav , Bačlija Sušić Blaženka , Lapat Goran
Published: January 2022

This research aimed to collect and combine all data on working with a highly visually impaired student in individual piano lessons and to determine a way of adopting new compositions and communication and cooperation between students and teachers. The qualitative method of case study, in which the methods of non-participatory observation and semi-structured interview were applied, concluded that the success of making music depends mostly on the approach and competencies of teachers in teaching such a student and that there are ways to overcome low vision as an obstacle in playing a musical instrument.
PERFORMANCE EVALUATION OF ETHYLENE-VINYL ACETATE MODIFIED BITUMEN AND MIXTURES
Authors: Marjan Hamza
Published: January 2022

Interconnectivity necessitates the use of transportation facilities and infrastructure. All highway design agencies seek acceptable, long-lasting, and cost-effective strategies while designing these facilities. The traffic demands on roads are much higher than they have been in the past. Increased traffic loads, larger traffic volumes, and insufficient maintenance have all contributed to serious road surface distress (e.g., rutting and cracking) due to rapid development. As conventional asphalt combinations are unable to withstand high axle loads and tire pressures, interest in polymer-modified asphalt has grown. Polymer modification of asphalt is one of the most effective ways to improve asphalt qualities. The practical temperature range of binders is greatly expanded by polymers. The inclusion of the polymer can considerably improve the binder qualities by increasing the stiffness of the bitumen and enhancing its temperature susceptibility, enabling the building of safer roads and lower maintenance costs. This research presents a laboratory investigation of the Ethylene Vinyl Acetate (EVA) polymer-modified bitumen. NHA-B gradation, PARCO 60/70 grade bitumen, and EVA polymer of TPI Polene Public Company Limited were used. Penetration, softening point, ductility, and viscosity tests were used to evaluate the conventional properties of the asphalt binders. Three different percentages of polymers were used i.e., 2%, 4%, and 6%. The impact of the EVA polymer on permanent deformation and moisture susceptibility was investigated. A double wheel tracker (DWT) was used to quantify permanent deformation (rutting), and a Universal Testing Machine (UTM) was used to examine moisture susceptibility using an Indirect Tensile Strength (ITS) test. For different percentages of bitumen volumetric properties according to Marshall Mix Design procedure were measured, and then Optimum Bitumen Content (OBC) was evaluated. Performance tests were performed using above mentioned percentages of EVA. The rutting potential of mixes was improved by the addition of EVA as compared to control asphalt mixes. The same effect of the polymer was on the moisture susceptibility of the prepared samples. This showed that EVA polymer can be used in flexible pavements to reduce permanent deformation and high-temperature problems.
LOCAL STABILITY ANALYSIS OF A PREDATOR-PREY DYNAMICS INCORPORATING BOTH SPECIES DENSITY INCREASING FUNCTIONAL RESPONSE
Authors: Samaddar Shilpa
Published: January 2022

Most of the functional responses which have been incorporated to formulate mathematical biology consider individual contact or predator cooperation. In this study, we have introduced a different functional response that describes the prey-predator system when predators form a line and cooperatively attack a group of predators. We have also described the effect of prey on this system. Additionally, we find all the equilibrium points and their local stability behaviour.
Investigation of Innovation in Wine Industry via Meta-Analysis
Authors: Dogru Ali , Peyrefitte Joseph
Published: January 2022

This study provides a systematic review of 76 relevant wine business studies published in the last 30 years. Our meta-analysis investigates six commonly used variables to explain wine innovation: absorptive capacity, technology adoption, sustainable practices, export orientation, firm size, and firm age. We also investigate the association between innovation and financial performance, using the reported effect sizes in the literature. Our meta-analysis reveals that absorptive capacity, technology adoption, sustainable practices, export orientation, and firm size positively correlate with innovation efforts, and innovation is positively associated with financial performance. However, we find no correlation between firm age and innovation. In addition to the meta-analysis, we apply basic text analytics and narrative review methodologies to identify a taxonomy of wine industry innovation according to four types of innovation. Based on our systematic literature review results, we make a series of managerial and policy recommendations for wine firms. Finally, we identify gaps in the literature and suggest future research directions.
Concepções do Transtorno do Espectro Autista - TEA: uma análise de trabalhos acadêmicos na perspectiva do ensino e da aprendizagem de Matemática
Authors: Canassa Veridiana , Borges Fábio Alexandre
Published: January 2022

Com esta pesquisa, objetivou-se identificar e analisar as concepções acerca do Transtorno do Espectro Autista presentes nas pesquisas sobre o ensino e a aprendizagem de Matemática para esses estudantes. Realizou-se uma Pesquisa Bibliográfica sistematizada com busca por publicações na Biblioteca Digital Brasileira de Teses e Dissertações, no período de 2010 a 2020. Como método de análise, trabalhamos com unidades de análise, segundo os pressupostos da Análise de Conteúdo. Identificou-se as seguintes concepções: o autista está dentro de um espectro; estudantes autistas possuem potencial de desenvolvimento para a aprendizagem de Matemática, quando consideradas suas especificidades; estudantes autistas podem aprender por meio das relações sociais; as especificidades do estudante autista se constituem como desafios para os processos de ensino e de aprendizagem de Matemática. Considera-se que as concepções encontradas nos textos se traduzem em parte da realidade, visto que há uma pluralidade de constituições de sujeitos autistas e das múltiplas realidades.
Tecnologia de apoio ao ensino e aprendizagem de programação em graduações tecnológicas profissionais: Juiz On-line
Authors: Giordano Carlos Vital , Lira Lucio Nunes de , Langhi Celi , Feitosa Marcelo Duduchi
Published: January 2022

As disciplinas de programação de computadores se posicionam entre as com maior índice de reprovação em graduações em computação. Porém, existem tecnologias com potencial para apoiar o processo de ensino e aprendizagem, permitindo aos discentes estudar extraclasse com uma abordagem diferente da tradicional, de aulas expositivas, tendo em seguida um feedback imediato por meio de resolução de problemas e avaliação automática das soluções construídas. A tecnologia Juiz On-line possui características fundamentadas na abordagem de ensino comportamental. A presente investigação objetiva analisar e discutir características da tecnologia, conectando-a com a abordagem comportamentalista, e propor sua aplicação em cursos superiores tecnológicos de computação.
Trabalho, conhecimento e educação: tributo a Mike Rose
Authors: Novelino Barato Jarbas
Published: January 2022

Este artigo foi escrito para lembrar Mike Rose, conselheiro do BTS, falecido dia 15 de agosto de 2021. O texto apresenta informações sobre a vida do homenageado, filho de garçonete, primeiro da família a chegar à universidade. A vida de Mike, criado numa área pobre de Los Angeles, já introduz para o leitor a obra dele. Percalços na universidade e a decisão de educar os desprivilegiados explicam as elaborações acadêmicas deste professor da UCLA. Nas partes seguintes do artigo, aparecem algumas das ideias desenvolvidas por Rose acerca de educação pública, erro, redação, testes, inteligência, pobreza. O desfecho é uma entrevista em que Mike Rose fala sobre o saber dos trabalhadores. Nessa fala ele destaca alguns dos pontos do The Mind at Work: Valuing the Intelligence of the American Worker, livro em que desenvolve ideias sobre o saber do fazer numa direção que pode ajudar instituições e especialistas em educação profissional a valorizar o conhecimento em ação dos trabalhadores manuais.
Formação profissional e certificação
Authors: Sant'Anna Tomás , Navarro Natalia
Published: January 2022

Nesta edição, a assessora técnica da Gerência de Prospecção e Avaliação Educacional do Departamento Nacional do Senac, Natalia Navarro, conversa com o professor Tomás Dias Sant´'Anna, secretário de Educação Profissional e Tecnológica (SETEC) do Ministério da Educação (MEC). O fio condutor da entrevista foi a relação entre formação profissional e certificação de trabalhadores, assim como a requalificação dos mesmos, abordando programas como a Plataforma Monitor das Profissões e o Sistema Nacional de Reconhecimento e Certificação de Saberes e Competências Profissionais (Re-Saber), recém-lançados pelo MEC.
Docência para a educação profissional
Authors: De Moares Francisco
Published: January 2022

Francisco de Moares resenha os livros Oficinas e conhecimento: um desafio para a atuação e a capacitação de docentes em educação profissional e tecnológica, do professor Jarbas Novelino Barato, e Didática profissional: princípios e referências para a educação profissional, organizado por Crislaine Gruber, Olivier Allain e Paulo Wollinger.
Perancangan Alat Pemupukan Jenis Pupuk Kristal Untuk Tanaman Palawija Berbasis Metode Rasional Dengan Memperhatikan Aspek Keergonomian
Authors: Zaenal Muttaqien  , Dody Mahendra
Published: January 2022

Industri pertanian merupakan salah satu penopang tata kehidupan masyarakat Indonesia. Dalam realita mayoritas petani di Indonesia masih menggunakan tata kerja dan peralatan tradisional dalam melakukan aktivitas pertanian mereka. Dengan kondisi itulah, para petani banyak mengalami kesulitan dalam mencapai produktivitas yang tinggi dalam hasil pertaniannya. Selain masalah produktivitas, tata cara kerja yang tidak mengikuti kaidah K3 (Keselamatan dan Kesehatan Kerja) di kalangan para petani telah menyebabkan potensi cedera pada bagian tubuh tertentu. Kegiatan pemupukan tanaman dengan menggunakan pupuk kimia berbentuk kristal seperti : urea, NPK, KCI, dll. pada umumnya masih dilakukan secara manual atau menggunakan peralatan seadanya. Sementara itu posisi badan ketika bekerja adalah membungkuk sehingga hal tersebut akan menimbulkan cedera ototpinggang.

Berdasarkan uraian di atas maka perlu dirancang suatu alat pemupukan jenis pupuk kristal untuk tanaman palawija yang dapat mengurangi potensi cedera otot pinggang. Dalam penelitian ini digunakan pendekatan metode rasional (Nigel Cross, 2008) dan konsep ergonomi. Variabel perancangan mengacu pada dimensi kualitas produ yaitu : performance, feature, reliabilitv, conformance, serviceability, durability, aesthetic, perceveid guality.

Solusi alternatif yang dihasilkan dalam penelitian ini ada 3 alternatif produk. Ada pun alternatif terpilih adalah alternatif ke 2 dengan nilai 3,706 sebagai solusi yang akan â€œmengakomodasi tujuan perancangan.
ANÁLISE CLIMÁTICA DOS MUNICÍPIOS DE PORTALEGRE/RN E FRANCISCO DANTAS/RN
Authors: Amorim José Robson , Medeiros Jacimaria Fonseca de
Published: January 2022

Inserido em um continente extenso e com diferentes agentes atmosférico vigentes, o Nordeste Brasileiro (NEB) se caracteriza por ser uma área com especificidades climáticas, possuindo temperaturas elevadas e precipitações irregulares. Ainda neste contexto está o Rio Grande do Norte (RN) e, consequentemente, a área de estudo desse trabalho. Realizou-se uma análise climática, num período de 30 anos (1973 – 2002), dos munícipios de Portalegre e Francisco Dantas, localizados na mesorregião Oeste Potiguar e onde se evidenciam exceções no tocante a clima. Para a metodologia, utilizou-se o arcabouço metodológico de Medeiros (2016) e como referência bibliográfica, foram empregados conceitos trabalhados por Schmidt (2014), Mendonça e Danni-Oliveira (2007), Ayoade (2016), Reboita et al. (2012), entre outros. Quanto os dados, os pluviométricos foram disponibilizados pela EMPARN e os de temperatura foram estimados em software, seguindo modelo de Cavalcanti e Silva (1994), denominado de Estima_T e que disponibiliza as médias, máximas e mínimas com base em dados de latitude, longitude e altitude. Após a tabulação dos dados, o balanço hídrico climatológico foi gerado, conforme modelo proposto por Thornthwaite e Mather (1955). Para Portalegre a média pluviométrica evidenciada foi de 929,52 mm e 23,22 ºC como média térmica. Já Francisco Dantas o valor médio de precipitação encontrado foi de 823,73 mm e sua média térmica é de 26,61 ºC. A partir dos dados gerados no balanço hídrico, tem-se as formulas C1wA’ (Megatérmico Subúmido Seco, com excedente hídrico moderado no verão) para Portalegre e C1dA’ (Megatérmico Subúmido Seco com pequeno ou nenhum excedente hídrico) para Francisco Dantas.
Surveillance of leishmaniasis cases from 15 European centres, 2014 to 2019: a retrospective analysis
Authors: Van der Auwera Gert , Davidsson Leigh , Buffet Pierre , Ruf Marie-Thérèse , Gramiccia Marina , Varani Stefania , Chicharro Carmen , Bart Aldert , Harms Gundel , Chiodini Peter L. , Brekke Hanne , Robert-Gangneux Florence , Cortes Sofia , Verweij Jaco J , Scarabello Alessandra , Karlsson Söbirk Sara , Guéry Romain , van Henten Saskia , Di Muccio Trentina , Carra Elena , van Thiel Pieter , Vandeputte Martin , Gaspari Valeria , Blum Johannes ,   LeishMan Surveillance network
Published: January 2022

Background

Surveillance of human leishmaniasis in Europe is mostly limited to country-specific information from autochthonous infections in the southern part. As at the end of 2021, no integrated analysis has been performed for cases seen across centres in different European countries.

Aim

To provide a broad perspective on autochthonous and imported leishmaniasis cases in endemic and non-endemic countries in Europe.

Methods

We retrospectively collected records from cutaneous, mucosal and visceral leishmaniasis cases diagnosed in 15 centres between 2014 and 2019. Centres were located in 11 countries: Belgium, France, Germany, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom. Data on country of infection, reason for travelling, infecting species, age and sex were analysed.

Results

We obtained diagnostic files from 1,142 cases, of which 76%, 21% and 3% had cutaneous, visceral, and mucosal disease, respectively. Of these, 68% were men, and 32% women, with the median age of 37 years (range: 0–90) at diagnosis. Visceral leishmaniasis was mainly acquired in Europe (88%; 167/190), while cutaneous leishmaniasis was primarily imported from outside Europe (77%; 575/749). Sixty-two percent of cutaneous leishmaniasis cases from outside Europe were from the Old World, and 38% from the New World. Geographic species distribution largely confirmed known epidemiology, with notable exceptions.

Conclusions

Our study confirms previous reports regarding geographic origin, species, and traveller subgroups importing leishmaniasis into Europe. We demonstrate the importance of pooling species typing data from many centres, even from areas where the aetiology is presumably known, to monitor changing epidemiology.
Editorial Motricidades (v. 5, n. 3)
Authors: Mizuno Fábio
Published: January 2022

Editorial Motricidades (v. 5, n. 3)
NIPPLE-SPARING MASTECTOMY WITH IMMEDIATE IMPLANT-BASED RECONSTRUCTION FOR PATIENTS WITH PURE DUCTAL CARCINOMA IN SITU
Authors: Frasson Antônio Luiz , Falcone Ana Beatriz , Miranda Isabela , Vollbrecht Betina , Frasson Mônica Adriana Rodriguez Martinez
Published: January 2022

Introduction: The presence of extensive intraductal component is strongly associated to the increasing risk of nippleareola complex (NAC) relapse. Most of the studies focusing on the outcomes of patients diagnosed with pure ductal carcinoma in situ (DCIS) who underwent nipple-sparing mastectomy (NSM) available in the literature performed immediate breast reconstruction using prosthetic implants (saline-filled implant or tissue expander) and autologous tissue flap. Objectives: The aim of our study was to evaluate the outcomes of patients diagnosed with DCIS who underwent NSM with immediate implant-based breast reconstruction. Methods: We retrospectively analyzed complication rates and oncological safety of 67 breast cancer patients diagnosed with pure DCIS who underwent NSM with immediate implantbased breast reconstruction between 2004 and 2018. Patients who underwent risk reduction NSM with accidental finding of DCIS were included in the study, and all patients were operated by the lead author. Tumor-nipple distance and tumor size were not exclusion criteria. Results: The indications of NSM were risk reduction breast surgery with accidental finding of DCIS (n=4. 6%), multifocal disease (n=16, 23.9%), compromised margins after breast-conserving surgery (n=11, 16.4%), tumors > 40 mm (n=16, 23.9%) and unfavorable relationships between tumor size and breast size or patient preference (n=20, 29.8%). The mean age of the patients was 46.8 years (range 30–75). Of the 69 procedures performed for DCIS, a total of three complications occurred, including two hematomas (2.9%) and one partial nipple necrosis (1.4%). After a mean follow-up of 60 months (range 3–183 months) the local recurrence rate was 8.9%. We observed a tendency of tumor multifocality being a risk factor for local relapse. The disease-free survival (DFS) rate was 90% and none of the patients died during the follow-up. Conclusions: Despite the local recurrence rate, we showed that NSM with immediate breast reconstruction using prosthetic implant is a feasible surgical approach with low complication rates and good disease-free and overall survival rates for patients with pure DCIS when BCS is not an option.
THORACIC DUCT INJURY AFTER MASTECTOMY - CASE REPORT AND LITERATURE REVIEW
Authors: Lima Juliana Ferreira de , Anderson Bruna , Nisida Antônio Carlos Toshihiro , Engel Fabiano Cataldi , Gebrim Luiz Henrique
Published: January 2022

Introduction: In adults, the thoracic duct carries about four liters of lymph per day, and its injury can lead to rapid accumulation in the pleural cavity, causing acute and chronic changes in lung dynamics. Thoracic duct injuries are uncommon and occur during surgical procedures in the thoracic region and trauma, such as esophagectomy, mediastinal and pleuro-pulmonary surgical procedures. Surgical injuries have been described after almost all types of thoracic surgical procedures, especially those performed in the upper left thoracic strait. The clinical diagnosis is based most often on the high output of the introduced chest drain, accompanied by a milky aspect. In addition, computed tomography, lymphoscintigraphy and lymphanangiography are possible methods for diagnosis. Clinical series on duct injuries after thoracic surgery report that in approximately 25% to 50% of cases spontaneous closure of the fistula occurs with conservative measures, after the introduction of parenteral nutrition or enteral diet with medium chain triglycerides. The other cases needed clinical and surgical treatment. Operative treatment consists of performing videothoracoscopy or right thoracotomy with identification of the lymphatic duct, followed by ligation. Case report: A 48-year-old woman, born in Santana do Parnaíba, state of São Paulo, with a diagnosis of breast cancer on the left, histological type of invasive breast carcinoma Luminal B, who underwent a modified radical mastectomy (Madden technique) on the left with immediate breast reconstruction. In the intraoperative period, important involvement of the left axillary lymph nodes was evidenced, which may have distorted lymphatic vessels and ducts. It evolved in the late postoperative period with high milky drainage in a suction drain in the left axillary region. Then, a hypothesis of thoracic duct injury was raised as a post-surgical complication. Biochemical analysis of milky secretion showed a high concentration of triglycerides and cytology describes the presence of proteinaceous material and macrophages. A conservative approach was adopted with adjustment of a hyperproteic, hypoglycidic and rich in medium chain triglyceride parenteral diet. The patient underwent lymphoscintigraphy, twenty days after the diagnostic hypothesis, but the fistula was not detected. Progressed with a decrease in the flow gradually until the drain was removed and she was discharged from the hospital in good condition. At the moment, the patient is undergoing adjuvant treatment for breast cancer.
Application Effect of PhET Virtual Laboratory and Real Laboratory on the Learning Outcomes of Class XI Students on Elasticity and Hooke's Law
Authors: Zulkifli Zulkifli , Azhar Azhar , Syaflita Dina
Published: January 2022

Physics is a scientific field that studies a lot of abstract concepts which in the learning process demands a lot of ability to do mental depictions of something being studied. This study aims to describe the cognitive learning outcomes of students who apply PhET virtual laboratory and Real Laboratory on elasticity and Hooke's law. The subjects of this study were two classes totaling 70 students of class XI MIPA SMA Negeri 2 Pekanbaru. This research uses quasi-experimental research with a quantitative approach and tests (pre-test and post-test) as data collection methods. To analyze the data, several analyzes were used, namely descriptive analysis (Absorption Power, Learning Effectiveness and Normal Gain Test) and Inferential analysis (t-test). The results showed that the average value of the pre-test class that implemented the PhET virtual laboratory was 44.40 and the post-test score was 76.20, while the average value of the pre-test class that implemented the Real Laboratory was 43.80 and the score was 43.80, post-test was 84.20. The absorption category achieved by the two classes is in the same category, namely good and the effectiveness of the learning used is in the effective category. This shows that the learning outcomes of the two classes have increased with the average gain test being classified in the moderate criteria, namely 0.54 and 0.70. In summary, the use of PhET Virtual Laboratory and Real Laboratory has a significant effect on students' cognitive physics learning outcomes. PhET Virtual Laboratory and Real Laboratory are effective for teaching Elasticity and Hooke's Law as an alternative to physics experimental activities.
Pengaruh Self-Efficacy Terhadap Setres Mahasiswa Dalam Pembelajaran Jarak Jauh Selama Pandemi
Authors:   STKIP PGRI Jombang, Anggoro Saputro Arnaz
Published: January 2022

Distance learning during the Covid-19 pandemic has several advantages and disadvantages. These constraints then become stressors that cause academic stress for students so that self-efficacy beliefs are needed in each individual to be able to face and resolve all these demands. This study aims to determine the effect of self-efficacy on student academic stress in distance learning during the Covid-19 pandemic. This research was conducted on 252 S1 Physical Education students of STKIP PGRI Jombang aged 18-21 years who were doing distance learning during the Covid-19 pandemic. Data collection tools are in the form of Student-Life Stress Inventory and General Self-efficacy (GSE) adaptation questionnaires. Data analysis in this study used a simple linear regression test technique. The results of this study indicate that self-efficacy has an effect on academic stress in students (R = 0.169; p = 0.000). This indicates that self-efficacy has a significant influence on the academic stress of S1 Physical Education students at STKIP PGRI Jombang.
Predicting COVID-19 cases, deaths and recoveries using machine learning methods
Authors:   Department of Agro-veterinary Science, Faculty of Natural and Life Sciences, University of Ziane Achour, BP 3117, Road of Moudjbara, Djelfa 17000, Algeria, Lounis Mohamed , Khan Farhan Mohammad ,   Department of Civil Engineering, BITS Pilani, Pilani Campus, India
Published: January 2022

In the presented work we applied three machine learning techniques to forecast and predict COVID-19 cases, deaths ad recoveries numbers in Algeria for the next six months using data from February 25th, 2020 to April 26th , 2021. These models are represented by the Gaussian process regression (GPR), the support vector machine (SVM) and the decision tree (DT). The plotting results and parameters evaluation pointed out that the Gaussian Process Regression (GPR) has the best performance. Prediction with this model showed that the number of cases, deaths and recoveries will increase in the next months Algeria recording a peak in the month of August and the curve will tend to decrease later.
Topological optimization processes
Authors: Michal Holdy  , Juraj Beniak
Published: January 2022

The method of topological optimization is based on a mathematical algorithm, which is based on the distribution and intensity of detail stress on the investigated component. It was developed using the Rhino-Grasshopper theory. This is a complicated FEM analysis with the help of the Nastran solver in the Siemens NX software environment. The topology detail is controlled by the degree of iteration of the algorithm, changing the size and distribution of the elements in relation to the incoming force stresses of the FEM simulation. The goal of topological optimization is a clearly defined shape of the component for a given design solution.
Role of nitric oxide in prevention diabetic nephropathy in females after menopause
Authors: Arwa Ahmed Abdel-Raheem  , Heba Ibrahim Hamed  , El-Sayed Fahim  , Ayman Saber Mohamed
Published: January 2022

Background: Type 2 diabetes mellitus (T2DM) is a complex disease, which affects many organs besides the pancreas such as the liver, brain, eye, stomach, and kidney. Purpose: The current study aimed to evaluate role of nitric oxide in prevention diabetic nephropathy in females after menopause. Methods: Our study was carried out on 90 females and 90 males with T2DM aged over 45 years, randomly selected from the outpatient clinic of the National Institute for Diabetes and Endocrinology (NIDE). T2DM patients were divided into 3 subgroups; subgroup 1: patients without any complications, subgroup 2: patients with nephropathy complications (DN), and subgroup 3: patients with cardiovascular compactions (CVD). Results: Result showed that dyslipidemia and oxidative stress was more pronounced in females rather than in male. While, kidney function markers was worse in male than female. Conclusion: The current study shows that diabetic females are more susceptible to cardiovascular disease than males due to the depletion of estrogen in postmenopausal women, causing oxidative stress. On the other hand, diabetic males are more susceptible to diabetic nephropathy than females due to a decrease in nitric oxide level, which is considered a kidney protective factor.
Condominium Hotel (Condotel) marketing and buying regulations in Indonesia
Authors: Zulfina Susanti  , Sri Endah Wahyuningsih  , Gunarto
Published: January 2022

The arrangement of the condotel agreement in Law Number 20 of 2011 concerning Flats is not yet clear, as shown by the absence of a dictum governing hotel condos. Hotels, while Condominiums or flats are only related to the ownership of flats that are more in the context of private settlements, the absence of a clear Condotel arrangement makes Condotel owners often lose money. The purpose of this study is to analyze the current Condominium Hotel (CONDOTEL) arrangement in Indonesia and analyze the weaknesses of the current Condominium Hotel (CONDOTEL) arrangement in Indonesia; the research paradigm in this dissertation is constructivism with non-doctrinal research methods with a sociological juridical approach. The results of existing research state that the implementation of hotel condominium agreements so far does not have a juridical footing in Indonesia, this has resulted in many developers and builders who often seek big profits without heeding the principles of good ethics in buying and selling agreements and managing hotel condominiums. The weakness in the hotel condominium agreement policy is the weakness of the legislation in the form of not regulating the contents of the hotel condominium agreement and the position of the hotel condominium in Law Number 20 of 2011, the weakness of law enforcement in the form of no supervision related to the sale and purchase agreement and hotel condominium management. , and the habitual factor of hotel condominium development and construction actors who seek profit through sale and purchase agreements and hotel condominium management by excluding consumers or hotel condominium owners.
Analisis Kelayakan Usaha Budidaya Burung Murai Batu di Desa Binangun Kecamatan Singgahan Kabupaten Tuban
Authors: Hirawan Dwi Bambang , Badriyah Nuril , Yatma Alfian Adi
Published: January 2022

Budidaya burung berkicau serta burung hias merupakan salah satu kegemaran   masyarakat Indonesia. Burung kicau atau burung hias sangat digemari oleh masyarakat sebab lahan yang dibutuhkan lahan yang cukup luas serta tidak menimbulkan pencemaran lingkungan yang secara signifikan di lingkungan. Burung berkicau juga dapat berkicau dengan indah, sehingga dapat dijadikan hiburan bagi masyarakat. Apabila hal tersebut dikelola dan dapat dimanfaatkan secara optimal, maka dapat mendapatkan keuntungan secara ekonomis, mampu meningkatkan pendapatan masyarakat,bahkan memiliki peluang yang cukup besar sebagai ajang bisnis. Tujuan dari enelitian ini ialah untuk mengetahui profil peternak Burung Murai Batu serta menganalisis kelayakan usaha budidaya Burung Murai Batu di Desa Binangun. Total biaya yang dikeluarkan oleh peternak pada usaha budidaya Burung Murai Batu sebesar Rp 110.164.000 pendapatan dari usaha budidaya Burung Murai Batu diperoleh dari hasil penjualan anakan burung serta indukan afkir. Total penerimaan yang di terima oleh peternak sebesar Rp. 10.237.792 /bulan. Dari hasil penelitian total keuntungan yang diterima selama 1 tahun adalah Rp. 122.853.500. Hasil analisis kelayakan usaha yang dilakukan dapat diketahui dengan menghitung total biaya modal dibagi keuntungan bersih per bulan, demikian biaya pengembalian modal dapat tercapai selama 10 bulan 8 hari. Dari hasil penelitian yang telah dilakukan, bahwa usaha budidaya But=rung Murai Batu sangat mengutungkan serta layak untuk dikembangkan.
Pengaruh Penambahan Level Gula Merah pada Air Minum terhadap Konsumsi Pakan, Konsumsi Air, dan Pertambahan Bobot Badan Itik Pedaging Fase Starter
Authors: Winata Adi , Dahlan Mufid , Fadlilah Anik
Published: January 2022

Itik peking merupakan satu dari temak unggas penghasil daging yang sangat berpotensi selain ayam. Gula merah merupakan sumber tambahan energi cepat tersedia bagi itik karna mudah diserap. Penambahan gula merah dalam air minum pada itik akan memperbaiki pertumbuhan maupun daya hidup, dan bertujuan memperbaiki konsumsi pakan, konsumsi air serta pertambahan bobot badan. Materi pada penelitian yakni day old duck (DOD) Peking pedaging berjumlah 80 ekor yang berjenis kelamin tidak dibedakan (Unsex). Metode pada penelitian yakni Rancangan Acak Lengkap (RAL) pola searah dengan 4 perlakuan serta 4 ulangan. Penambahan level gula merah pada air minum itik diberikan secara berturut-turut yakni P0 = (ransum basal + air minum dengan pemberian gula merah 0%), P1 = (ransum basal + air minum dengan pemberian gula merah 5%),  P2 = (ransum basal + air minum dengan pemberian gula merah 10%) dan P3 = (ransum basal + air minum dengan pemberian gula merah 15%) pada itik berumur 0 hari sampai 14 hari. Hasil analisis ragam (ANOVA) memperlihatkan bahwa penambahan level gula merah pada air minum memiliki pengaruh nyata (P<0,05) terhadap konsumsi pakan serta pertambahan bobot badan, namun penambahan level gula merah pada air minum tidak berpengaruh nyata (P>0,05) terhadap konsumsi air. Hasil penelitian menunjukkan bahwa nilai rerata konsumsi pakan pada P0 (33,632 gr/ekor/hari), P1 (37,666 gr/ekor/hari), P2 (32,201 gr/ekor/hari) dan P3 (28,938 gr/ekor/hari). Nilai rataan konsumsi air pada P0 (209,393 ml/ekor/hari), P1 (194,955 ml/ekor/hari), P2 (192,670 ml/ekor/hari) dan P3 (196,607 ml/ekor/hari). Nilai rataan pertambahan bobot badan pada P0 (19,905 gr/ekor/hari), P1 (19,658 gr/ekor/hari), P2 (17,256 gr/ekor/hari) dan P3 (16,708 gr/ekor/hari). Berdasarkan uji DUNCAN kesimpulan pada penelitian ini bahwa perlakuan yang memberikan nilai terbaik terhadap konsumsi pakan dan pertambahan bobot badan adalah P1 yaitu dengan memberikan 5% gula merah dalam air minum  itik.
Pengaruh Umur terhadap Pola Pertumbuhan Kambing Boerka Jantan di UPT. Agri Science Technopark Universitas Islam Lamongan
Authors: Karlinda Afrilian Norma , Badriyah Nuril , Dewi Ratna Kumala
Published: January 2022

Tujuan penelitian untuk mengetahui pengaruh umur terhadap pola pertumbuhan kambing Boerka jantan di UPT. Agri Science Technopark Universitas Islam Lamongan. Materi yang dipakai yakni kambing boerka jantan berjumlah 17 ekor (3 ekor kambing prasapih, 9 ekor lepas sapih, dan 5 ekor kambing dewasa). Variabel yang diamati meliputi berat badan, lingkar dada, tinggi pundak, serta panjang badan. Data yang didapat ditabulasi dan dianalisis secara kuantitatif dengan analisis regresi polynomial. Hasil penelitian menunjukkan bahwa pola pertumbuhan kambing boerka jantan mengikuti kurva sigmoid (S) dengan persamaan regresi polinomial berganda berturut-turut, yaitu :  bobot badan y = 0,003x3 - 0,1226x2 + 2,748x + 2,1532;  lingkar dada y = -0,1095x² + 3,8853x + 39,898; tinggi pundak y = -0,0358x² + 2,1436x + 41,699; dan panjang badan y = -0,0431x2 + 2,1206x + 43,398. Dengan nilai koefisien determinasi berturut-turut : bobot badan 98,47%,  lingkar dada 89,25%, tinggi pundak 92,32%, dan panjang badan 59,88%. Pola pertumbuhan bobot badan serta ukuran tubuh lainnya pada kambing Boerka jantan di UPT. Agri Science Techopark UNISLA mengalami pertumbuhan yang terus meningkat mulai dari umur 0-18 bulan. Hal ini terjadi karena ternak belum mencapai usia tua. Apabila umur ternak semakin tinggi maka bobot badan maupun ukuran tubuh lainnya juga akan bertambah. Nilai koefisien determinasi paling tinggi pada bobot badan 98,47% dan terendah pada panjang badan 59,88%. Perihal ini menunjukkan bahwa adanya pengaruh umur terhadap pola pertumbuhan kambing Boerka jantan di UPT. Agri Science Techopark UNISLA.