bluuebunny/crossref_metadata_2025 huggingface dataset:
Digitalization of hydraulic rotary drilling process for continuously mechanical profiling of siliciclastic sedimentary rocks
Authors: Wang X. F. , Zhang Z. J. , Yue W. V. , Yue Z. Q.
Published: March 2023

Hydraulic rotary drilling can offer the essential information and core samplesa for the researches on solid earth. Recording the factual field drilling data and analyzing the hydraulic rotary coring process are challenging yet promising to utilize the massive drilling information in geophysics and geology. This paper adopts the drilling process monitoring (DPM) technique and records the four parameters of displacement, thrust pressure, upward pressure, and rotation speed in real-time series for profiling the siliciclastic sedimentary rocks along 108 m deep drillhole. The digitalization results with 107 linear zones represent the spatial distribution of drilled geomaterials including superficial deposits (fill, loess, gravelly soil), mudstone, silty mudstone, gritstone, and fine sandstone. The constant drilling speeds varying from 0.018 to 1.905 m/min present the in-situ coring resistance of drilled geomaterials. Furthermore, the constant drilling speeds can identify the strength quality of soils to hard rocks. The thickness distributions of the six basic strength quality grades are presented for all the sedimentary rocks and each individual type of the seven soil and rocks. The in-situ strength profile determined in this paper can be used to assess and evaluate the in-situ mechanical behavior of geomaterial along the drillhole and can provide a new mechanical-based assessment for determining the spatial distribution of geological strata and structures in subsurface. They are important since the same stratum at different depths can have different mechanical behavior. The results provide a novel quantitative measurement for continuously in-situ mechanical profiling by digital drilling data. The findings of the paper can offer a new and effective method for refinement and upgrading of in-situ ground investigation, and can provide researchers and engineers with a novel tool and valuable reference to digitize and utilize factual data of current drilling projects.
Near-field sensor array with 65-GHz CMOS oscillators can rapidly and comprehensively evaluate drug susceptibility of Mycobacterium
Authors: Kikuchi Shojiro , Yamashige Yoshihisa , Hosoki Ryosuke , Harata Masahiko , Ogawa Yuichi
Published: March 2023

Multidrug-resistant tuberculosis (MDR-TB) is a major clinical problem. Because Mycobacterium, the causative agent of tuberculosis, are slow-growing bacteria, it takes 6–8 weeks to complete drug susceptibility testing, and this delay contributes to the development of MDR-TB. Real-time drug resistance monitoring technology would be effective for suppressing the development of MDR-TB. In the electromagnetic frequency from GHz to THz regions, the spectrum of the dielectric response of biological samples has a high dielectric constant owing to the relaxation of the orientation of the overwhelmingly contained water molecule network. By measuring the change in dielectric constant in this frequency band in a micro-liquid culture of Mycobacterium, the growth ability can be detected from the quantitative fluctuation of bulk water. The 65-GHz near-field sensor array enables a real-time assessment of the drug susceptibility and growth ability of Mycobacterium bovis (BCG). We propose the application of this technology as a potential new method for MDR-TB testing.
Characterizing the top-down sequencing of protein ions prior to mobility separation in a timsTOF
Authors: Graham Katherine A. , Lawlor Charles F. , Borotto Nicholas B.
Published: March 2023

Here, we demonstrate that protein ions can be dissociated prior to mobility analysis in a trapped ion mobility spectrometry device. Generated product ions are mobility separated enabling facile assignment of near isobaric ions.
Mobile multi-configuration clinical translational Raman system for oral cancer application
Authors: Maryam Siddra , Konugolu Venkata Sekar Sanathana , Ghauri M. Daniyal , Fahy Edward , Nogueira Marcelo Saito , Lu Huihui , Beffara Flavien , Humbert Georges , Ni Riordain Richeal , Sheahan Patrick , Burke Ray , Wei Kho Kiang , Gautam Rekha , Andersson-Engels Stefan
Published: March 2023

Early diagnosis of oral cancer is critical to improve the survival rate of patients.
C-Terminal modification of polytheonamide B uncouples its dual functions in MCF-7 cancer cells
Authors: Xue Yun-Wei , Miura Kensuke , Itoh Hiroaki , Inoue Masayuki
Published: March 2023

Polytheonamide B is a large natural product that forms an ion channel in the plasma and lysosomal membranes. Herein, we report the uncoupling of the dual functions of polytheonamide B by synthetically incorporating a tertiary amine at the C-terminus.
Oxoammonium salt-promoted diverse functionalization of saturated cyclic amines with dinucleophiles
Authors: He Yan , Liu Qimeng , Yang Jintao , Liu Yunfei , Zhang Xinying , Fan Xuesen
Published: March 2023

A facile strategy for the tunable preparation of difunctionalized alicyclic amines and 2-alkylquinoxalines through oxoammonium salt-promoted cascade reactions of saturated cyclic amines with 1,3/1,4-dinucleophiles is presented.
Recent progress in polyaniline-based composites as electrode materials for pliable supercapacitors
Authors: Shanmuganathan Mohanraj Alias Ayyappan , Raghavan Akshaya , Ghosh Sutapa
Published: March 2023

This review outlines the significance of recent findings regarding PANI-based composites, the corresponding synthetic strategies, and their role as electrode materials in the enhancement of the electrochemical performance of flexible supercapacitors.
Metacognitive regulation in organic chemistry students: how and why students use metacognitive strategies when predicting reactivity
Authors: Blackford Katherine A. , Greenbaum Julia C. , Redkar Nikita S. , Gaillard Nelson T. , Helix Max R. , Baranger Anne M.
Published: March 2023

Problem solving is a key component of authentic scientific research and practice in organic chemistry. One factor that has been shown to have a major role in successful problem solving in a variety of disciplines is metacognitive regulation, defined as the control of one's thought processes through the use of planning, monitoring, and evaluation strategies. Despite the growing interest in assessing and promoting metacognition in the field of chemical education, few studies have investigated this topic in the context of organic chemistry students. To gain a deeper understanding of how and why students make use of strategies related to metacognitive regulation in their approaches to solving problems, we conducted interviews with Organic Chemistry I, Organic Chemistry II, and graduate organic chemistry students and used multiple measures to examine students’ metacognition. As a part of these interviews, students verbalized their thoughts as they worked on complex predict-the-product problems and completed a self-report instrument indicating which planning, monitoring, and evaluation strategies they had used while completing each problem. Think-aloud protocols were analyzed for the presence of each of the behaviors included on the self-report instrument, and students’ use of metacognitive strategies was compared to identify differences between students with different levels of experience and between students who generated more and less successful solutions to the problems. Students who generated more successful solutions to the problems tended to report using a greater number of metacognitive strategies. When asked why they did or did not use certain metacognitive strategies, students indicated a number of factors, such as not feeling able to use these strategies effectively or believing that using these strategies was unnecessary. The results of this study support the importance of teaching metacognitive problem-solving strategies in organic chemistry courses and suggest several methods for the assessment and instruction of metacognition.
An analytical method for the determination of glyphosate and aminomethylphosphoric acid using an anionic polar pesticide column and the application in urine and serum from glyphosate poisoning patients
Authors: Zhang Hao , Dou Jianrui , Miao Runfeng , Hu Jiacai , Huo Zongli , Zhang Feng , Ji Wenliang
Published: March 2023

The concentration of glyphosate and aminomethylphosphoric acid in serum and urine from intoxication patients was measured by the established method, and the downward trend of the two compounds during treatment was analyzed.
Polarized coherent emission outside high-symmetry points of dye-coupled plasmonic lattices
Authors: Piccotti Diego , Trevisani Mirko , Pirruccio Giuseppe , Kalinic Boris , Cesca Tiziana , Mattei Giovanni
Published: March 2023

Off-normal polarized lasing emission can be obtained from dye-coupled hexagonal Au nanodome arrays made by nanosphere lithography.
Three-body interaction effects in heterolytic hydrogen splitting by frustrated Lewis pairs
Authors: Szczȩśniak Małgorzata M. , Chałasiński Grzegorz
Published: March 2023

The reaction of heterolytic dihydrogen splitting by frustrated Lewis pairs P(R)3 and B(C6F5)3 (where R = t-butyl and 1-adamantene) is driven by strong three-body contributions which originate from the induction and charge transfer effects.
Reactant conversion–intercalation strategy toward interlayer-expanded MoS2 microflowers with superior supercapacitor performance
Authors: Wang Jingwei , Zheng Xuejun , Dong Yaoyong , Chen Longyuan , Chen Lijuan , He Wenyuan
Published: March 2023

A novel reactant conversion–intercalation strategy is proposed to synthesize interlayer-expanded MoS2 with superior supercapacitor performance, which avoids the complicated control associated with foreign species in conventional synthesis strategies.
Active foam: the adaptive mechanics of 2D air–liquid foam under cyclic inflation
Authors: Kroo L. A. , Bull Matthew Storm , Prakash Manu
Published: March 2023

We study how cyclic activity (inflation–deflation) in foam effects its surrounding passive structure. The structure adapts and locally strengthens over 5–10 cycles, while propagating a subtle long-range “swirl” signal in the confined material.
The interplay between lytic polysaccharide monooxygenases and glycoside hydrolases
Authors: Sørlie Morten , Keller Malene Billeskov , Westh Peter
Published: March 2023

In nature, enzymatic degradation of recalcitrant polysaccharides such as chitin and cellulose takes place by a synergistic interaction between glycoside hydrolases (GHs) and lytic polysaccharide monooxygenases (LPMOs). The two different families of carbohydrate-active enzymes use two different mechanisms when breaking glycosidic bonds between sugar moieties. GHs employ a hydrolytic activity and LPMOs are oxidative. Consequently, the topologies of the active sites differ dramatically. GHs have tunnels or clefts lined with a sheet of aromatic amino acid residues accommodating single polymer chains being threaded into the active site. LPMOs are adapted to bind to the flat crystalline surfaces of chitin and cellulose. It is believed that the LPMO oxidative mechanism provides new chain ends that the GHs can attach to and degrade, often in a processive manner. Indeed, there are many reports of synergies as well as rate enhancements when LPMOs are applied in concert with GHs. Still, these enhancements vary in magnitude with respect to the nature of the GH and the LPMO. Moreover, impediment of GH catalysis is also observed. In the present review, we discuss central works where the interplay between LPMOs and GHs has been studied and comment on future challenges to be addressed to fully use the potential of this interplay to improve enzymatic polysaccharide degradation.
Research and development suggestions on the coordinated development of green cities based on spss data processing basis
Authors: Lv Chaoqi
Published: March 2023

Based on extensive reading of domestic and international research on green city development, this paper uses a combination of qualitative and quantitative methods to conduct an in-depth study of the interactive and coordinated development of a city PRED and its model from the perspective of systemic analysis based on grey correlation theory, and then evaluate the green city development of a city. Based on PRED system theory, we analyze the deep meaning of green city and clarify the interaction between them and the guiding significance of PRED system theory for green city development. Design a city green city evaluation index system, use gray correlation analysis method, and build a gray correlation evaluation model of green city coordination ability of a city based on PRED system analysis. This paper has researched and thought about the coordinated development of green cities based on the basic data processing. The optimization and re-planning study was carried out on the development strategy of the previous period. The future urban development of Wei has laid some research theoretical foundation.
Evaluation of Urban Vitality in Shandong Based on Multi-source Data
Authors: Xu Zhen , Lu Ping
Published: March 2023

This paper focuses on the new problem of urban vitality development, and designs 32 link indicators from 6 dimensions, including economy, talent, innovation, industry, people’s livelihood and international, to measure urban vitality by using comprehensive evaluation method. The results of the study show that (1) from the overall index, Jinan and Qingdao have been steadily ranked in the top two in the province; (2) from the time dimension of 2018-2022, cities such as Heze and Linyi have made the most obvious progress; Yantai and Weifang have performed more stable over the years. Based on the results of the study, the paper goes on to make a number of recommendations to provide a strategic basis for further improving urban vitality in Shandong.
Research on the Interaction Space Evaluation of Aged Care Architecture in Villages and Towns from the Perspective of Inclusiveness: Take Wuyang County as an Example
Authors: Zhou Min , Wu Fan , Zhu Nana
Published: March 2023

As China’s population keeps aging, the hollowing-out problem in villages and towns gradually becomes prominent, accompanied by the increasing number of residents in aged care architecture. As one social occasion, the interaction space of aged care architecture is of great significance for the elderly. The present study, therefore, collects and analyzes relevant evaluation indicators from the perspective of inclusiveness. The AHP-Fuzzy comprehensive evaluation method was adopted to construct an evaluation system for the interaction space of aged care architecture in villages and towns in China. In order to verify the system’s accuracy and effectiveness, the evaluation of Xin’an Town in Wuyang County was carried out. The research is helpful for the design of interaction space of future aged care architecture in China and the improvement of the existing buildings, providing a certain reference for the inclusive evaluation of the interaction space of aged care architecture in villages and towns.
On the role and value of rural planning management in rural construction
Authors: Gu Yaqing , Huang Sizhong , Guan Baihui , Bai Yu , Yan Zhao
Published: March 2023

Rural planning is to make the countryside neat and tidy through planning, including farmland planning and sewage discharge planning. All individual buildings shall not be built outside the planned area or the construction land at will, and shall not be built in the demolition area with incomplete infrastructure. The planning and construction of pits and ponds shall be implemented to control agricultural pollution. The overall deployment of long-term social, economic, scientific and technological development is the basic basis for guiding rural development and construction.
Research on the development path of characteristic village B&B in Tongzhou District Based on Qualitative Comparative Analysis
Authors: Liu Xiaoxi , Peng Kaiyu , Ma Jing
Published: March 2023

Village B&B is an important format of rural tourism, and it is one of the important ways to promote rural economic growth and revitalization in an all-round way. Tongzhou District, based on the Universal Theme Park and the Grand Canal as the promenade, has a material and cultural environment suitable for incubating boutique village B&B, and is an important experimental field to realize the high-quality development of rural village B&B. In this paper, qualitative comparative analysis method (QCA) is introduced to make a comparative analysis between the 10 cases selected for the first batch of village B&B in Tongzhou District and the other 10 cases that were not selected. The analysis is mainly based on the evaluation indicators summarized in the Basic Requirements and Evaluation of Tourist Homes (LB/T 065-2019), related literature and case studies of boutique village B&B, and the index configuration of selected cases is studied. The research is supposed to provide feasible suggestions for shaping the characteristics of villagers’ lodge in other townships in Tongzhou District, and further to realize the goal of creating a “golden business card” for quality village B&B in Tongzhou District.
Research on the path of artificial intelligence to empower intelligent port upgrading and transformation
Authors: Du Xinke
Published: March 2023

As the key nodes of the global comprehensive transportation network, ports play a pivotal role in global trade and shipping. With the progress of artificial intelligence technology and the promotion of intelligent port development concept, intelligent port will be the inevitable trend and choice of all countries in the world. This paper analyzes the application status and problems of artificial intelligence in promoting the construction of smart ports, discusses the typical application of artificial intelligence in the intelligent port upgrading, and details the practical application of artificial intelligence in the construction of intelligent port, including container electronic tags, unmanned driving technology, intelligent ship stowage, and intelligent port scheduling. Finally, the corresponding optimization countermeasures of intelligent port are put forward.
Optimization of Green Space Form Assessment in Beijing-Tianjin-Hebei Cities under “Carbon Reduction - Quality Improvement” Green Innovation
Authors: Wan Yunshan , Zhu Sihan
Published: March 2023

Under the background of the “two-carbon” goal, balancing the demand for land for economic development and ensuring the ability of urban green ecological carbon sink is the key issue of urban sustainable development. Based on the synergy theory, this paper uses the morphological spatial pattern analysis (MSPA) method to calculate the area ratios of seven landscape types in 13 cities within the BeijingTianjin-Hebei urban agglomeration, and forms an assessment system (factor evaluation) for green space forms of cities that are not carbon neutral, near carbon neutral and already carbon neutral based on relevant indexes, and then gives optimization suggestions: First, the larger the proportion of the area of urban construction land intersecting or contacting with natural patches and corridors, the easier it is to improve the carbon storage capacity of green space. Second, on the basis of ensuring a certain proportion of development space after, landscape types with a high degree of aggregation have a certain effect on the score improvement of the urban innovation index. Fourth on the basis of ensuring a certain proportion of development space, a reasonable ratio of green space between the core area and the fringe area is beneficial to the realization of the coordinated development mode of economy and ecology.
Pricing and inventory Decision Optimization under subscription mode in Supply chain management
Authors: Hu Kefan
Published: March 2023

This paper investigates the current situation of subscription mode, applies it to the joint management of pricing and inventory in supply chain management, builds the product pricing and inventory model under subscription mode, and verifies the model derivation and results based on the joint decision model of pricing and inventory, and simulates the decision-making process of the model by computer programming. By comparing the difference between the theoretical model of joint decision of pricing and inventory under uncertain supply and demand conditions and the model of joint decision of pricing and inventory under subscription mode, analyzing the influencing factors and exploring the optimization method of product pricing and inventory model algorithm under subscription mode. The results show that: (1) in supply chain management, it is necessary to solve the problem of supply and demand balance through effective joint decision of pricing and inventory, and effectively improve the competitiveness of logistics enterprises.(2) The introduction of subscription mode in the joint management of pricing and inventory can reduce the uncertainty of both sides, so as to better solve the problem of inventory replenishment strategy and pricing decision under the condition of supply and demand uncertainty than the traditional decision-making model, so as to achieve the coordination of supply chain under the uncertain environment.
Study on flexural resistance and hydration mechanism of magnesium phosphate cement
Authors: Ding Benzhe , Teng Fei , Liu Zhiyin
Published: March 2023

Based on a large number of research data at home and abroad, this paper designed an experiment to complete the research on the mechanical properties and durability of magnesium phosphate cement by the ratio of magnesium phosphorus, fly ash content and pH value. On this basis, the effects of curing methods and different concentrations of hydrochloric acid on hydration products of magnesium phosphate cement were studied, and the mechanism of action was analyzed. Finally, when the M/P ratio was 4, with the increase of curing time, the strength of MPC increases gradually. When M/P is greater than 4, the flexural strength of MPC all shows a certain degree of shrinkage. In addition, fly ash can reduce the shrinkage of magnesium phosphate cement-based materials; The content of K-type struvite (KMgPO4ꞏ6H2O) in MPC can be increased under acid curing (pH=2) and water curing conditions.
Air Pollution Control in Ha-Chang City Cluster - Empirical analysis of social networks based on inter-city and inter-governmental perspectives
Authors: Kang Wei , Li Nuolin
Published: March 2023

Atmospheric pollution has always been an intractable regional problem that requires the cooperation of various cities and departments within a city cluster to achieve good results. As one of the key urban agglomerations in China, the Ha-Chang urban agglomeration is also plagued by the problem of air pollution. With the help of institutional collective action theory and social network analysis, we analyze the current situation of air pollution cooperation in the Ha-Chang urban agglomeration from two perspectives: inter-city cooperation network and inter-governmental cooperation network, and put forward suggestions for improving the strategic height and precision of treatment by calculating indicators such as network density and network centrality.
Research on Dynamic Evaluation of Metro Passenger Credit
Authors: Li Zhaojun , Zhu Ming , Zhang Ning
Published: March 2023

With the expansion of metro network, the large passenger flow in peak hours has brought great challenges to metro operation. While upgrading the security inspection, the traffic efficiency of passengers in metro stations has also been affected. Considering public security and security inspection efficiency, using the method of passenger credit rating to establish a differentiated security inspection mode has become the development direction of intelligent security inspection in the future. It is necessary to study the passenger credit evaluation system due to a lack of research on metro passenger credit scoring. However, previous research focused on static credit evaluation rather than dynamic credit evaluation. This paper introduces motivation factor, time weight and night safety reduction coefficient to conduct dynamic passenger credit evaluation.
Akute Extremitätenischämie – was gibt es Neues?
Authors: Steiner Sabine , Schmidt Andrej
Published: March 2023

Was ist neu?

Aktueller Stand und Wahl der Revaskularisationsstrategie. Rezente Studien zeigen bei Patienten mit peripherer arterieller Verschlusskrankheit eine Inzidenz der akuten Extremitätenischämie von 0,8 pro 100 Patientenjahre. Aktuelle Leitlinien betonen die Notwendigkeit einer raschen Behandlung im Gefäßzentrum mit einer Option der offen-chirurgischen und interventionellen Revaskularisierung unter situativer Anpassung der Strategie. Im Vergleich zur offenen Operation zeigte sich in einer schwedischen Analyse mit Propensity score Matching ein Benefit für ein endovaskuläres Vorgehen bei ALI im Hinblick auf die Sterblichkeitsrate nach 30 Tagen und einem Jahr. Ähnliche Ergebnisse wurden in einer US-Analyse gezeigt, da hier die Sterblichkeitsrate während des stationären Aufenthalts bei endovaskulär behandelten Patienten ebenfalls geringer war. In manchen Fällen kann eine Kombination aus offenen und endovaskulären Techniken im Sinne eines Hybrideingriffes erforderlich sein.

Endovaskuläre perkutane Interventionsoptionen bei ALI. Die endovaskulären Revaskularisierungsoptionen bei akuter Extremitätenischämie konzentrieren sich zunehmend auf ein breites Spektrum mechanischer Thrombektomiegeräte, basierend auf unterschiedlichen Funktionsprinzipien. Als Vorteil können mit manchen Systemen auch organisierte, subakute Thromben entfernt werden, die durch eine Lysetherapie häufig nicht ausreichend behandelt werden können. Eine lokale Thrombolyse kann so oft eingespart werden oder ist nur für kurze Zeit erforderlich, was das Blutungsrisiko deutlich reduziert.

Akute Extremitätenischämie und COVID-19. Die bei Patienten mit COVID-19-Erkrankung gehäuft beobachteten Gerinnungsstörungen und damit verbundenen thrombotischen Komplikationen spielen auch eine Rolle für das Auftreten einer akuten Extremitätenischämie bei COVID-19. Zwar zeigen die meisten betroffenen Patienten typische Risikofaktoren für ALI, aber auch bislang weitgehend gesunde Patienten ohne typische Risikofaktoren oder Vorerkrankungen können betroffen sein. Vergleichende Analysen zeigen hohe Sterblichkeits- und niedrige technische Erfolgsraten bei Revaskularisation.
Patient access – Zugang zu Innovationen in der Onkologie
Authors: Berger-Thürmel Karin , Westphalen C. Benedikt , von Bergwelt-Baildon Michael
Published: March 2023

Was ist neu?

Innovative onkologische Diagnostik und Therapien Im Vergleich zu anderen europäischen Ländern steht in Deutschland eine Vielzahl an innovativen Therapieoptionen für die Behandlung von Patienten mit Krebs zur Verfügung. Aktuell besteht die Herausforderung in der Versorgung vor allem darin, allen Patienten, die einen Nutzen von innovativen Therapien erfahren könnten, unabhängig vom Wohnort und Behandlungsumfeld diese Optionen zum richtigen Zeitpunkt anzubieten zu können.

Zugang über klinische Studien, molekulare Tumorboards Klinische Studien sind häufig die erste Möglichkeit für einen kontrollierten Zugang zu onkologischer Innovation. Der Abbau von bürokratischen Prozessen sowie die Steigerung der Transparenz über aktuell rekrutierende Studien ist zwingend notwendig, um mehr Patienten den frühen Zugang über Sektorengrenzen hinweg zu ermöglichen. Auch das Konzept dezentraler klinischer Studien und (virtueller) molekularer Tumorboards ist geeignet, um mehr Patienten einen potenziellen Studieneinschluss zu ermöglichen.

Kosten innovativer onkologischer Therapie Der bestmögliche Einsatz einer wachsenden Zahl innovativer und kostenintensiver Diagnostik- und Therapiemöglichkeiten für unterschiedlichste, patientenindividuelle Situationen erfordert den niederschwelligen transsektoralen Austausch, d.h. Kommunikation zwischen (zertifizierten) onkologischen Kompetenzzentren und Ärzten in der Breite der medizinischen Versorgung, die im Versorgungsalltag gleichzeitig die Großzahl der deutschen Krebspatienten behandeln und die gesamte Bandbreite der immer komplexeren onkologischen Therapielandschaft abdecken sollen.

Innovative Therapien: unterschiedlicher Zugang in den Regionen Die überfällige Implementierung von digitalen Möglichkeiten für die sektorenübergreifende Zusammenarbeit ist unbedingte Voraussetzung, um Patienten mit räumlich größerer Entfernung zu einem Kompetenz- bzw. Studienzentrum Zugang zu Innovation zu ermöglichen, die am Wohn- bzw. Behandlungsort nicht vorgehalten wird.

Neue Versorgungsformen: optimierter Zugang zu innovativer Versorgung Zur Entwicklung und Erprobung neuer Versorgungsformen ist die Beteiligung aller am Versorgungsprozess beteiligten Verantwortlichen notwendig, um strukturelle Voraussetzungen gemeinschaftlich zu verbessern, nachhaltige Anreize zu schaffen und entsprechend notwendige Kapazitäten vorzuhalten. Grundlage hierfür ist eine fortlaufende, konzertierte Bereitstellung von Evidenz zur Versorgungssituation, z.B. im Kontext der gesetzlichen Krebsregistrierung und klinischer Register an onkologischen Zentren.
Übersicht über die klinischen Merkmale des Li-Fraumeni Syndroms und die aktuelle europäische Leitlinie des ERN GENTURIS
Authors: Kratz Christian Peter , Steinke-Lange Verena , Spier Isabel , Aretz Stefan , Schröck Evelin , Holinski-Feder Elke
Published: March 2023

Patienten mit einem Tumor-Risiko-Syndrom haben ein deutlich erhöhtes Risiko, im Laufe des Lebens an Krebs zu erkranken. Hinweise auf ein Tumor-Risiko-Syndrom können eine positive Familienanamnese für Tumorerkrankungen oder ein ungewöhnlich frühes Erkrankungsalter geben. Die Diagnose eines Tumor-Risiko-Syndroms ermöglicht die Empfehlung eines risikoangepassten Tumor-Früherkennungs-Programms für den Patienten und die (asymptomatischen) Risikopersonen in der Familie. Hierdurch können mögliche Tumoren früh erkannt und somit fortgeschrittene Tumorerkrankungen häufig verhindert werden. Das Li-Fraumeni Syndrom geht mit einem deutlich erhöhten Risiko insbesondere für Sarkome und Brustkrebs einher, häufig wird es bei den Betroffenen jedoch klinisch nicht diagnostiziert. Dieser Artikel gibt einen Überblick über das klinische Bild, die genetischen Ursachen sowie die Besonderheiten in der Diagnostik und Versorgung der Patienten mit einem Li-Fraumeni Syndrom. Die Initiative resultiert aus dem europäischen Referenznetzwerk GENTURIS, das sich die Verbesserung der Erfassung und Versorgung von Patienten mit Tumor-Risiko-Syndromen zur Aufgabe gemacht hat. Ein erster Schritt ist die aktuelle Veröffentlichung einer europäischen Leitlinie für das Li-Fraumeni Syndrom, die hier zusammengefasst und im Kontext bestehender Empfehlungen diskutiert wird.
Evidenzbasierte und strukturierte Diagnostik in der MR-Mammografie anhand des Kaiser-Score
Authors: Baltzer Pascal Andreas Thomas , Krug Kathrin Barbara , Dietzel Matthias
Published: March 2023

Hintergrund Die MR-Mammografie (MRM) ist als sensitivstes Verfahren zur Detektion von Brustkrebs integraler Bestandteil der modernen Mammadiagnostik. Aufgrund umfangreicher multiparametrischer Bildinformationen gilt die Befundung der MRM jedoch als schwierig. Klinische Entscheidungsregeln kombinieren diagnostische Kriterien in einem Algorithmus. Damit unterstützen sie Radiologen dabei, objektive und exakte sowie weitgehend von der Untersuchererfahrung unabhängige MRM-Diagnosen zu stellen.

Methodik Narrativer review. Der Kaiser-Score (KS) als klinische Entscheidungsregel für die MRM wird eingeführt. Befundkriterien werden erläutert, Strategien zur klinischen Entscheidungsfindung diskutiert und illustriert.

Ergebnisse Entwickelt mit Methoden des maschinellen Lernens wurde der Kaiser-Score in internationalen Studien unabhängig validiert. Dabei ist der KS unabhängig von der Untersuchungstechnik. Anhand von auf T2w- und kontrastangehobenen T1w-Aufnahmen fassbaren diagnostischen BI-RADS-Kriterien ermöglicht der KS die objektive und genaue Differenzialdiagnose von benignen und malignen Befunden in der MRM. Ein Flowchart leitet den Leser über maximal 3 Zwischenschritte zu einem Punktwert, entsprechend einer Malignomwahrscheinlichkeit. Damit lässt sich der KS direkt einer konkreten BI-RADS-Kategorie zuordnen. Individuelle Managemententscheidungen sollten dabei auch den klinischen Kontext berücksichtigen, was anhand von typischen Beispielen dargestellt wird.

Kernaussagen: 

Zitierweise
Verletzungen in der 1. Inline-Skaterhockey-Bundesliga
Authors: Breves Florian , Wegner Alexander , Jäger Marcus , Mayer Constantin
Published: March 2023

Inline-Skaterhockey ist eine aus dem Eishockey entstandene Sportart, die in Deutschland von ca. 6000 Sportlern ausgeübt wird. Es gibt allerdings einige Unterschiede zum Eishockey, die zu einem besonderen Risikoprofil der Athleten führen.

Alle 315 aktiven Spieler der deutschen Inline-Skaterhockey-Bundesliga 2018 und 2019 wurden online mittels eines anonymisierten Fragebogens über Verletzungen, Trainingshäufigkeit, Trainingsinhalte und Sportausrüstung angeschrieben. 178 Athleten antworteten und 116 Fragebögen konnten ausgewertet werden (100 Männer, 8 Frauen, 8 keine Angabe/16 Goalie, 55 Stürmer, 44 Verteidiger).

Die Gesamtverletzungsinzidenz lag bei 36,98 pro 1000h. Unter den leichten Verletzungen (Wunden, Prellungen und stumpfe Muskelverletzungen) waren Beinverletzungen (9,4/1000h) und Armverletzungen (7,2/1000h) am häufigsten. Relevante Verletzungen (Frakturen, Luxationen und Bandverletzungen) waren am häufigsten am Fuß (2,4/1000h) (n=147) sowie am Kopf (1,9/1000h) (n=140) und am Knie (1,7/1000h) (n=126). Von 76 Frakturen entstanden 48 (63,2%) durch direkten oder indirekten Körperkontakt. Torhüter haben im Vergleich zu Feldspielern mehr Knieverletzungen, allerdings haben Feldspieler mehr Schulterverletzungen. Kopfverletzungen (Frakturen, Zahnverletzungen, Schädelhirntraumata) zeigten sich bei Spielern ohne Gesichtsschutz signifikant häufiger (3,0/1000h vs. 1,8/1000h). Spieler, welche kein zusätzliches Fitnesstraining durchführten, zeigten signifikant mehr relevante Verletzungen. Auch Knieverletzungen waren in dieser Gruppe häufiger(4,2/1000h vs. 1,3/1000h). Die Dauer der Dehnübungen zeigt eine negative Korrelation mit der Gesamtverletzungsinzidenz (0min: 53,5/1000h, 1–4min: 55,8/1000h, 5–9min: 23,5/1000h, ≥10min: 21,5/1000h, p<0,05). Insbesondere leichte Verletzungen werden durch Dehnübungen hochsignifikant seltener. Inline-Skaterhockey in der 1. Bundesliga zeichnet sich durch ein hohes Verletzungsrisiko aus, welches mit dem professionellen Eishockey verglichen werden kann. Schwerwiegende Verletzungen entstehen im Inline-Skaterhockey am häufigsten durch Körperkontakt. Relevante Verletzungen kommen am häufigsten am Kopf und an der unteren Extremität vor. Die Durchführung von Fitnesstraining zeigte einen positiven Einfluss auf die Verletzungshäufigkeit. Im Rahmen der weiterführenden Professionalisierung des Sportes können diese Erkenntnisse zur Prävention von Verletzungen im Inline-Skaterhockey beitragen.
Positionspapier: ICD-Codierung der chronischen Rhinosinusitis mit Nasenpolypen (CRSwNP) im ICD-10-GM als Grundlage für eine Therapie mit Biologika
Authors: Becker S. , Laudien M. , Förster-Ruhrmann U. , Olze H. , Rudack C. , Chaker A. M. , Hagemann J. , Huppertz T. , Hoffmann T. K. , Dazert S. , Deitmer T. , Strieth S. , Wrede H. , Schlenter W. , Welkoborsky H. J. , Wollenberg B. , Bärhold F. , Klimek F. , Kianfar R. , Zuberbier J. , Cuevas M. , Hintschich C. A. , Guntinas-Lichius O. , Stöver T. , Bergmann C. , Werminghaus P. , Gröger M. , Beutner C. , Weber R. K. , Hildenbrand T. , Hoffmann A. S. , Klimek L.
Published: March 2023

Hintergrund Die chronische Rhinosinusitis mit Nasenpolypen (CRSwNP) ist eine multifaktorielle entzündliche Erkrankung der Schleimhäute von Nase und Nasennebenhöhlen. In Deutschland sind 3 verschiedene monoklonale Antikörper für die Indikation „Zusatztherapie zu intranasalen Glukokortikosteroiden für die Behandlung Erwachsener mit schwerer chronischer Rhinosinusitis mit Nasenpolypen“ zugelassen. Um die Verordnung in der zugelassenen Indikation (In-Label) zu dokumentieren, ist neben einer Dokumentation zahlreicher medizinischer Parameter die korrekte Auswahl der ICD-10-GM-Codierung entscheidend. Hierfür existieren in Deutschland bislang keine konsentierten Empfehlungen.

Methoden Basierend auf der internationalen Literatur und bisherigen Erfahrungen werden von einem Expertengremium von AeDA, DGHNO-KHC und Deutschem CRS-Register Codierungsmöglichkeiten von CRS und CRSwNP analysiert und auf dieser Basis eine konsentierte Empfehlung für die ICD-10-GM-Codierung in Deutschland ausgesprochen.

Ergebnis Die Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme ICD-10-GM (International Classification of Diseases, 10. Revision, German Modification) ist die amtliche Klassifikation zur Verschlüsselung von Diagnosen in der ambulanten und stationären Versorgung in Deutschland. Der ICD-10-GM unterscheidet nicht adäquat zwischen heute anerkannten klinischen und immunologischen Differenzierungen der CRSsNP und der CRSwNP. Dennoch wird insbesondere bei indiziertem Einsatz von Biologika in der Therapie der schweren CRSwNP eine möglichst exakte Verschlüsselung mit den Codes J33.8 (im Einzelfall J33.1 oder J33.9) empfohlen.

Schlussfolgerungen Das Verständnis über die immunologischen Grundlagen der CRSwNP eröffnet neue Behandlungsansätze mit monoklonalen Antikörpern für Patienten mit schwerer, unkontrollierter Erkrankung. Hier geben wir Empfehlungen für eine adäquate ICD-10-GM-Codierung in Deutschland.
Imaging Recommendations for Diagnosis, Staging, and Management of Pancreatic Cancer
Authors: Shetty Nitin Sudhakar , Agarwal Ujjwal , Choudhari Amit , Gupta Anurag , PG Nandakumar , Bhandare Manish , Gala Kunal , Chandra Daksh , Ramaswamy Anant , Ostwal Vikas , Shrikhande Shailesh V. , Kulkarni Suyash S.
Published: March 2023

Pancreatic cancer is the fourth most prevalent cause of cancer-related death worldwide, with a fatality rate equal to its incidence rate. Pancreatic cancer is a rare malignancy with a global incidence and death ranking of 14th and 7th, respectively. Pancreatic cancer cases are divided into three categories without metastatic disease: resectable, borderline resectable, or locally advanced disease. The category is determined by the tumor's location in the pancreas and whether it is abutting or encasing the adjacent arteries and/or vein/s.

The stage of disease and the location of the primary tumor determine the clinical presentation: the pancreatic head, neck, or uncinate process, the body or tail, or multifocal disease. Imaging plays a crucial role in the diagnosis and follow-up of pancreatic cancers. Various imaging modalities available for pancreatic imaging are ultrasonography (USG), contrast-enhanced computed tomography (CECT), magnetic resonance imaging (MRI), and 18-fluoro-deoxy glucose positron emission tomography (FDG PET).

Even though surgical resection is possible in both resectable and borderline resectable non-metastatic cases, neoadjuvant chemotherapy with or without radiotherapy has become the standard practice for borderline resectable cases as it gives a high yield of R0 resection.
Corifollitropin Alfa for Controlled Ovarian Stimulation in Assisted Reproductive Technologies: State of the Art
Authors: Carvalho Bruno Ramalho de
Published: March 2023

Physical and emotional burdens during the journey of infertile people through assisted reproductive technologies are sufficient to justify the efforts in developing patient-friendly treatment strategies. Thus, shorter duration of ovarian stimulation protocols and the need for less injections may improve adherence, prevent mistakes, and reduce financial costs. Therefore, the sustained follicle-stimulating action of corifollitropin alfa may be the most differentiating pharmacokinetic characteristic among available gonadotropins. In this paper, we gather the evidence on its use, aiming to provide the information needed for considering it as a first choice when a patient-friendly strategy is desired.
Imaging Recommendations for Diagnosis, Staging, and Management of Gastric Cancer
Authors: Chatterjee Argha , Shah Diva , Roy Bipradas , Ghosh Joydeep , Ray Soumendranath , Patra Anurima , Gehani Anisha , Gupta Bharat , Ghosh Priya , Mukhopadhyay Sumit , Chandra Aditi , Lingegowda Dayananda , Sen Saugata
Published: March 2023

Gastric cancer is the second most common cause of cancer-related death in Indian men and women aged between 15 and 44 years. Most patients present at an advanced stage of disease. Surgically resectable disease usually requires a standard gastric resection and D2 lymphadenectomy. Imaging, especially with computed tomography scan of abdomen as well as thorax, is necessary for localization, nodal mapping, and metastatic workup of gastric cancer. In this review, we discuss current imaging recommendations for gastric carcinoma.
Multisystem Imaging Recommendations/Guidelines: In the Pursuit of Precision Oncology
Authors: Mahajan Abhishek , Chakrabarty Nivedita , Majithia Jinita , Ahuja Ankita , Agarwal Ujjwal , Suryavanshi Shubham , Biradar Mahesh , Sharma Prerit , Raghavan Bagyam , Arafath Rasheed , Shukla Shreya
Published: March 2023

With an increasing rate of cancers in almost all age groups and advanced screening techniques leading to an early diagnosis and longer longevity of patients with cancers, it is of utmost importance that radiologists assigned with cancer imaging should be prepared to deal with specific expected and unexpected circumstances that may arise during the lifetime of these patients. Tailored integration of preventive and curative interventions with current health plans and global escalation of efforts for timely diagnosis of cancers will pave the path for a cancer-free world. The commonly encountered circumstances in the current era, complicating cancer imaging, include coronavirus disease 2019 infection, pregnancy and lactation, immunocompromised states, bone marrow transplant, and screening of cancers in the relevant population. In this article, we discuss the imaging recommendations pertaining to cancer screening and diagnosis in the aforementioned clinical circumstances.
Meta-analysis and Construction of Core Indicator Field of Pediatric Bronchitis Treated by Chinese Herbs Acupoint Application Therapy
Authors: Qian Zhenzhen , Li Rui , Duan Juan , Jing Zhiwei , Gao Rui
Published: March 2023

Objective Our objective was to explore the commonly used herbs, acupoints, and efficacy evaluation indicators of Chinese herbs acupoint application therapy in the treatment of pediatric bronchitis, screen and construct the core index field, and systematically evaluate the efficacy and safety of Chinese herbs acupoint application therapy in the treatment of this disease.

Methods Chinese periodical databases such as China National Knowledge Infrastructure, Wanfang database, VIP Information, and Chinese Biomedical Literature database were searched, and the literature information was extracted manually to establish data tables for data analysis and the key efficacy evaluation index field. The quality of the included studies was assessed using the Cochrane Systematic Bias Risk Assessment Tool and the relevant efficacy indicators were meta-analyzed using RevMan 5.3 software.

Results The most commonly used herbs in acupoint application therapy were wind-cold dispersing herbs and cough-asthma relieving herbs. Feishu (BL 13), Danzhong (RN 17), and Tiantu (RN 22) were the main acupoints. The core indicators were effective rate, improvement of main symptoms/signs, onset time, disappearance time, traditional Chinese medicine (TCM) syndrome score, and symptom score. Meta-analysis results showed that the total effective rate was 0.11 (0.08, 0.33) (Z = 8.64, p < 0.00001), I
2 = 39%; due to the heterogeneity of cough, expectoration, asthma, and other indicators, the meta-analysis was abandoned.

Conclusion In terms of total efficiency, Chinese medicine acupoint application therapy is superior to conventional Western medicine in efficacy and shortening the time of symptoms of pediatric asthmatic bronchitis. However, as the quality of the evidence included in the study is medium and low, and in the selection of indicators, there are more composite and relatively subjective indicators such as total effective rate, TCM syndrome score, and symptom score. Therefore, it is necessary to further standardize the efficacy indicators in this field and carry out high-quality and detailed Chinese medicine clinical randomized controlled trials.
Cervical Cancer Screening with DNA-HPV Testing and Precancerous Lesions Detection: A Brazilian Population-based Demonstration Study
Authors: Teixeira Julio Cesar , Vale Diama Bhadra , Discacciati Michelle Garcia , Campos Cirbia Silva , Bragança Joana Froes , Zeferino Luiz Carlos
Published: March 2023

Objective To evaluate the rates of precancerous lesions, colposcopy referral, and positive predictive value (PPV) by age groups of a population-based screening with DNA-HPV testing.

Methods The present demonstration study compared 16,384 HPV tests performed in the first 30 months of the program with 19,992 women tested in the cytology screening. The colposcopy referral rate and PPV for CIN2+ and CIN3+ by age group and screening program were compared. The statistical analysis used the chi-squared test and odds ratio (OR) with 95% confidence interval (95%CI).

Results The HPV tests were 3.26% positive for HPV16-HPV18 and 9.92% positive for 12 other HPVs with a 3.7 times higher colposcopy referral rate than the cytology program, which had 1.68% abnormalities. Human Papillomavirus testing detected 103 CIN2, 89 CIN3, and one AIS, compared with 24 CIN2 and 54 CIN3 detected by cytology (p < 0.0001). The age group between 25 and 29 years old screened by HPV testing had 2.4 to 3.0 times more positivity, 13.0% colposcopy referral, twice more than women aged 30 to 39 years old (7.7%; p < 0.0001), and detected 20 CIN3 and 3 early-stage cancer versus 9 CIN3 and no cancer by cytology screening (CIN3 OR= 2.10; 95%CI: 0.91–5.25; p = 0.043). The PPV of colposcopy for CIN2+ ranged from 29.5 to 41.0% in the HPV testing program.

Conclusion There was a significant increase in detections of cervix precancerous lesions in a short period of screening with HPV testing. In women < 30 years old, the HPV testing exhibited more positivity, high colposcopy referral rate, similar colposcopy PPV to older women, and more detection of HSIL and early-stage cervical cancer.