bluuebunny/crossref_metadata_2025 huggingface dataset:
Drug utilization pattern of analgesics after a surgical procedure in a tertiary care hospital: a prospective observational single centre cohort study
Authors: Sharma Christian S. , Nerurkar Rajan P.
Published: August 2023

Background: the study aimed to understand the prescription pattern of analgesics used in the post-operative period after a general surgical procedure in a tertiary care hospital in India and estimate the severity of post-operative pain up to 48 hours. Such a study was not done in this institute of recent hence it was carried out.
Methods: 266 adults of either gender were recruited and prescription pattern analyzed over a period of 1 year beginning January 2021 to December 2021 from the post-operative general surgery wards of a tertiary care hospital in India. Patient interview and records were used to collect data. Follow ups at 4, 24 and 48 hours were undertaken to assess pain according to the visual analogue scale (VAS) that was analyzed using the Friedman’s test followed by the post hoc Dunn’s test.
Results: an average of 1.52±0.58 analgesics were prescribed per patient. Paracetamol was most commonly used followed by tramadol and diclofenac. All analgesics prescribed were a part of the national list of essential medicines. Effective pain management is feasible as seen by the significant (p<0.0001) reduction in average pain score from 4.75±1.35 to 3.05±1.18 at 24 hours and further to 2.16±1.04 at 48 hours.
Conclusions: Use of analgesics prescribed from a standardized list is effective in majority of patients.
Association of proton pump inhibitors with renal dysfunction: a cross-sectional study
Authors: Singh Mamata , Bala Ritu , Jain Amit , Singh Harminder , Prakash Ajay
Published: August 2023

Background: Proton pump inhibitors are the most frequently prescribed class of medications for prescription and over-the-counter, and the data suggest that comorbidities, polypharmacy, self-medication, no clear indications and duration beyond the recommended guidelines PPIs use are associated with renal dysfunction. Aim was to study the proportion of renal dysfunction among patients using oral PPIs and determine the association between the duration of oral PPIs use and the severity of renal dysfunction.
Methods: The data collection of 250 patients was done at the time of contact, which included demographic profiles, complete medical history, physical examination, and laboratory investigation in this study. For analysis, name of oral PPIs used, duration and dosage of oral PPIs therapy, laboratory values of serum blood urea, serum creatinine, eGFR, and serum electrolytes parameters have been considered.
Results: Amongst 250 patients with PPIs used for a week, 23 patients showed mildly reduced kidney function (p=0.000), PPIs used for >1 to 2 weeks, 29 patients showed grade 2 kidney function (p=0.001), while PPIs used for >2-3 weeks only two patients showed grade 3 kidney function (p=0.44). Patients aged >50 years in all groups showed grade 2 renal function, regardless of the duration of PPIs use. Increasing age, males, rural, smoking, and alcoholics were the risk factors for renal dysfunction. PPIs use significantly impacts eGFR.
Conclusions: Collectively, this study found a significant association between PPIs use and renal dysfunction. PPIs used for >2 weeks in elderly patients have shown a 4−fold increased risk of developing renal dysfunction.
A prospective study on antibiotic resistance pattern in patients with urinary tract infection
Authors: Singh Swastika Raj , Thomas Shibi Mary , Ramaiah Balakeshwa
Published: August 2023

Background: Antibiotics are a blessing to the mankind in the realm of medical treatment. Quite contrary to that fact, they may cause risks in medical treatments of patients if these antibiotics are not taken under medical guidelines. In the current scenario it is a huge challenge for selecting appropriate antibacterial agents for the treatment of UTI. This study aims to evaluate the prescription & resistance pattern of antibiotics in patients with urinary tract infection.
Methods: A prospective observational study was carried out for a period of 1 year. Data on 100 research participants' reports and the results of their tests for antibiotic resistance were taken from the microbiology department's records, evaluated, and represented as percentages. Observations were made and meticulously recorded.
Results: Out of 100 study participants, Escherichia coli was the most common pathogen with a total of (35%) followed by Klebsiella (17%), Enterococcus with (16%). E. coli were highly resistant to Ampicillin (88.6%) and Cefazolin (88.6%), Ceftraixone (85.3%). Klebsiella were highly resistant to Ampicillin (100%) Cefazolin (93.3%), Cefuroxime (85.7%). Enterococcus were highly resistant to Tetracycline (92.9%) Ciprofloxacin (85.7%), Levofloxacin (81.8%). Where, E. coli were highly sensitive to Amikacin, Imipenem, Ertapenam. Klebsiella were highly sensitive to Meropenem, Cefoperazone/Sulbactam, Amikacin. Enterococcus was highly sensitive to Linezolid, Teicoplanin, Vancomycin.
Conclusions: Most of the identified bacteria were resistant to several of the popular antibiotics used in clinical settings. Consequently, it is vital to prescribe antibiotics rationally both before and after culture reports.
Long-COVID versus adverse event following COVID vaccination among students and staff of tertiary care teaching hospital
Authors: Javadekar Tanuja  B. , Barai Bhavin P. , Mistry Chirag B. , Sareen Ishaan , Vaishnav Riya
Published: August 2023

Background: Long COVID is an important public health concern requiring proper defining, quantifying and describing following SARS-CoV infection with differentiation from adverse events due to COVID vaccination. So, this study was planned to analyze adverse effect of COVID19 vaccination or drug for COVID treatment versus consequences of COVID19 infection.
Methods: Self-reported data was collected through questionnaire-based survey by voluntary participation of healthcare staff. Percentage of participant developing various events was analyzed by enlisting sign, symptom, co-morbidity and medication history. Association between COVID-19 infection with number of doses of COVID-19 vaccine taken was analyzed by Chi Square Test with p value <0.05. Association between presence of specific sign, symptom after COVID infection or side effect after COVID vaccination was analyzed by Chi-Square Test with p value <0.05. 
Results: Overall total 985 (59.58%) participants were analyzed and among them maximum number of participants (60.30%) reported as COVID-19 positive during the third wave with history of diagnosed COVID positive twice (57.87%). Participants with presence of co-morbidity were more likely to develop symptoms (p<0.001). On analysis, fever, body ache, headache, sore throat and fatigue were significantly more likely to develop after COVID infection as compared to after COVID vaccination (p<0.001). 
Conclusions: This study by exploratory survey highlights heterogeneity of Long COVID sign or symptom that’s seen predominantly in person with co-morbidity and a few of them were mimicking adverse events after COVID vaccinations.
Pantoprazole induced black hairy tongue: a case report
Authors: Krishnan Divya G. , Keloth Anukesh Vasu , P. Neethu
Published: August 2023

Black hairy tongue (BHT) is characterized by abnormally hypertrophied and elongated filiform papillae, appearing as blackish discoloration on the dorsal surface of the tongue. BHT has been reported as an adverse drug reaction to different categories of drugs. However, pantoprazole induced BHT has been rarely reported. We present the case of a 42-year-old female, admitted in the surgery ward with postoperative wound infection, for which she was prescribed oral clarithromycin and pantoprazole. On the third day of starting medications, she complained of blackish discoloration on the dorsal surface of the tongue with an alteration of taste sensation, which was clinically and microscopically diagnosed as BHT. Suspecting BHT as an adverse drug reaction to pantoprazole, it was stopped, while clarithromycin was continued for the full course. She was also advised to scrape her tongue thrice daily, drink adequate fluids and maintain good oral hygiene. On the third day after stopping pantoprazole, black discoloration and alteration of taste sensation resolved completely. WHO-UMC causality assessment scale showed a ‘probable’ association of the adverse drug reaction with pantoprazole. Physicians should be aware of the possibility of BHT with the use of pantoprazole and that it completely resolves on stoppage of the drug, mechanical debridement and good oral hygiene.
Case report on splenic abscess with pleural effusion caused by enteric fever
Authors: Shaji Shiby Sara , George Shone Padinjarethil , Varughese Mohan , Abraham Thomas Jacob
Published: August 2023

Splenic abscess is an infrequent complication of enteric fever caused by Salmonella typhi. The incidence rate ranges from 0.14-2%. Clinical manifestations are often nonspecific and may be presented as fever with left upper quadrant abdominal pain and a palpable tender mass. Diagnosis is often difficult and splenic abscess management is based on surgical interventions and antibiotic therapy. In this case report we would like to highlight splenic abscess with left reactive pleural effusion as a rare complication of Salmonella typhi infection.
Use of liraglutide in the patient with obesity and type 2 diabetes mellitus: a literature review
Authors: Cancino Jorge A. Diaz , Álvarez Cristian J. Sosa , Ramírez Karen A. Zebadúa
Published: August 2023

Obesity and type 2 diabetes mellitus represent two of the most pressing public health challenges globally. In recent decades, an alarming increase in the prevalence of both conditions has been observed, which has led to a significant increase in the burden of disease and an increased search for effective therapeutic strategies. As evidence accumulates on the efficacy and safety of Liraglutide in this patient population, a comprehensive review of the available scientific literature is necessary. The objective of this literature review is to analyze and synthesize relevant studies investigating the use of liraglutide in patients with obesity and type 2 diabetes mellitus, in order to provide a comprehensive view on its effectiveness, indications, complications and management. In conclusion, the use of liraglutide in patients with obesity and type 2 diabetes mellitus has been shown to be an effective therapeutic option to improve glycemic control, promote weight loss and reduce cardiovascular risk. This drug, as a GLP-1 receptor agonist, stimulates insulin secretion, suppresses excessive glucagon release and delays gastric emptying, which contributes to the improvement in glycemic control.
Formulation and evaluation of herbal hair serum-a review
Authors: R. Anusha , N. Akhila , J. Nikhitha , K. Harish , Shaikh Abdull Rajjak , Y. Sony , . Inamul
Published: August 2023

In the mammalian system the hair follicle is known to the most significant organ that determine, appearance, gender distinction, provides intense temperature protection and plays a role in self-defence. The younger generations have begun to suffer extreme hair loss problem due to many reasons. The hair loss is not temporary in most cases. but it results in alopecia. Many people suffering from hair loss is in search of multiple treatments due to extreme anxiety and tension. To improve hair growth and to prevent hair loss, hair root activation is required. Citrus sinensis is used to antidandruff protection hair care. It’s had antibacterial and anti-inflammatory properties. Nigella sativa improves the shine, strength, volume, and texture of hair. Flax seed is full of fatty acids and antioxidants that tend to remove pollutants and dead cells from the scalp. Coconut oil may help to moisturise and seal hair. They can help to prevent dry, flaky scalp and dandruff. This review article focuses on the materials required for the formulation of hair serum and various evaluation tests to evaluate hair serum.
Fiction contract: its importance in simulation-based medical education
Authors: Sharma Hritika , Patil Anant D. , Baviskar Ajit
Published: August 2023

Simulation-based education has become an integral part of education and training in high-risk professions and disciplines such as aviation, aerospace, military, nuclear power plants, medicine and healthcare. In the last decade, medical simulation has globally emerged as a powerful instructional technique across various specialties and disciplines. Despite its increasing popularity and various advantages, simulation-based medical education (SBME) poses a unique challenge, that is, realism. This is where the concept of fiction contract or suspension of disbelief comes into the picture. In this article we provide an overview of fiction contract in SBME including how can it be effectively addressed during training.
Brief remission of cardiac conduction defect under anaesthesia during trans-sphenoidal pituitary surgery
Authors: Kaur Kirandeep , Kaur Manpreet , Mahajan Shalvi
Published: August 2023

Acromegaly can cause paroxysmal arrhythmia and bundle branch blocks, which may or may not be symptomatic. Physiological stress induced by anaesthesia can exacerbate cardiac problems; nevertheless, reversal of such problems can also occur despite being uncommonly reported. We describe temporary remission of left bundle branch block (LBBB) to normal sinus rhythm under general anaesthesia.
A cross-sectional study of neonatal hearing impairment: understanding its prevalence and risk factors in a tertiary care hospital in Kerala, India
Authors: Raju Aarya S. , Pulimoottil Davis T. , Vithayathil Ancy A. , G. I. Sandhya , Jose Shilpa , Ajith Parvathy , K. B. Ashna , Manu Rhidhiq , Philip Angel C. , Joy Sneha M. , T. G. Krishna
Published: August 2023

Background: Congenital hearing loss is one of the most prevalent sensory impairments with severe consequences when undetected. The objective of neonatal hearing screening is to identify hearing impairments shortly after birth to initiate treatment as soon as possible and to allow affected children to enjoy normal development. The aim of the study was to determine the prevalence and identify the predisposing factors of HI among neonates in a tertiary care centre in Idukki district of Kerala using a universal neonatal hearing screening (UNHS) program, in an attempt to initiate early interventions in affected neonates.
Methods: This was a cross-sectional study conducted in the department of ENT, Al Azhar Medical College and Super Specialty Hospital, Thodupuzha, Kerala over a period of 1 year involving 646 neonates. The study excluded any newborn whose parent/guardian did not give consent for the study, or neonates with microtia grade II and above.
Results: The overall prevalence of HL in neonates in our study was 3.1 in 1000 live births out of which 61% were males and 39% females. The risk factors found in our study were preterm babies, maternal age >35, low birth weight, teenage pregnancy, primigravida, and neonatal jaundice requiring blood transfusion.
Conclusions: In a standard neonatal population, both at-risk and non-at-risk neonates warrant the immediate adoption of a universal hearing screening program for all neonates in India. Hence, we would like to stress the importance of identifying infants with HL, administering early treatment and performing appropriate screening tests in infants at the right time period.
Incidence of phlebitis among children having peripheral intravenous line in selected hospital, Siliguri
Authors: Kumar Primi , Dhar Ankita , Banik Susmita , Saha Anannya , Amrita Banik  , Biswas Prity , Roy Dipika , Mondal Nitushree , Khatun Sabina , Ghosh Aditi , Chanda Riya
Published: August 2023

Background: Vascular access is the most common and widely used medical device in hospital setting especially peripheral intravenous line rather than central venous line and it is more essential in the pediatric and newborn group in accessing and maintaining a safe and reliable venous access for continuous management. Though it is the most common procedure, complication like phlebitis, extravasation, induration, dislodgement related to PIVC are also high.
Methods: A prospective cohort study which included 86 children of age 1-7 years admitted in pediatric ward in selected hospital, Siliguri during the year 2023 in the month of May and June. Objective of the study was to find out the incidence of phlebitis among children admitted in pediatric ward. Observational method was adopted to collect data from the participants. Jackson’s VIP scale and FLACC scale was used to collect data along with demographic variables and peripheral intravenous catheter characteristics.
Results: The study revealed that all the 86 children developed phlebitis where 64% of children developed phlebitis Grade 2 of phlebitis and 19% grade 3 on day 2 from the day of insertion where on day 3 8% had grade 2 and 9% had grade 3. The mean duration of PIVC was 53.11±0.87 hours and the major risk factor associated with phlebitis was site of insertion (OR=33.8, 95% CI-0.5, 207).
Conclusions: By identifying early signs of phlebitis among children, one can manage it at appropriate time and can reduce the further complication related to the PIVC.
Radiolucent metallic foreign body: a case report
Authors: Mir Zahed Hussain , Kamal Osman Hassan  , Issa Mohammad Ridha , Jaiganesh T. T.
Published: August 2023

A 13-year-old boy who accidentally ingested an aluminum beverage can pull tab. Neck and chest radiographs did not reveal any ingested foreign body. This case report illustrates poor negative predictive value of conventional radiographs for a suspected aluminum foreign body and demonstrates superiority of CT for this purpose. In such presentations, it is imperative to have a low threshold for performing further diagnostic evaluation with CT due to the relatively high radiolucency of aluminum.
Neonatal arterial thrombosis at birth
Authors: Makwana Bhavi M. , Rabadia Priyanka J.
Published: August 2023

Neonatal thromboembolism occurs with various predisposition and triggers. Early diagnosis of the thrombosis is challenging and essential for therapeutic interventions. We herein report one newborn who presented with transient patient with arterial thrombosis underwent arterial Doppler and received low molecular weight heparin (LMWH) subcutaneously. Newborns suspected having arterial thrombosis may need urgent surgical intervention along with thrombolytic and anticoagulant therapy to prevent organ ischemia and amputation of extremities.
A rare case report of ovarian ectopic pregnancy – Expect the unexpected sometimes
Authors: Geetha A. Mangala , Natarajan Kalaivani
Published: August 2023

Ectopic pregnancy is implantation of an embryo at sites other than its normal location - the uterine cavity. The most common site for ectopic implantation is the fallopian tube, other rare sites being ovarian ectopic, cervical ectopic and caesarean scar ectopic. Ovarian ectopic pregnancy accounts to around 3% of all ectopics, incidence being 1 in 2000 to 1 in 60,000. In this rare form of ectopic the implantation and development of embryo occurs in the ovary and eventually ends with rupture before the end of first trimester causing catastrophic results due to hemorrhage and hemostatic imbalance and sometimes even death. This case report is of such a rare form of ectopic pregnancy reported at ISO-KGH, Department of Obstetrics and Gynaecology, Government Medical College, Omandurar Government Estate, Chennai.
Engaging Resistance
Authors: Gringle Meredith
Published: August 2023

In this article, I discuss the ways that contending with my own resistance around being a mother while researching mothers/mothering, inspired and shaped a study on maternal self-care. Using Judith Butler’s Gender Trouble (2006) as a beginning guide, I discuss how I developed a poetic hermeneutical phenomenology, which emerged as a way out of my resistance and into a deeper relationship with the texts and substance of my project. The purpose of the article is not to present findings; instead, I express my personal and theoretical rationale for the study, offer up my methodology, and provide examples of the poetic performances that steered my analyses. I also reflect upon the ways that I became folded within this project and how my own positionalities affected, and were affected by, engaging in this work. Lastly, I issue a call for qualitative researchers to make explicit our connections to our research, and to interrogate how these connections relate to our goals and gazes.
Schizo-Poetic Inquiry of a First-Year Doctoral Experience
Authors: Roberts Bucca Kate
Published: August 2023

Undertaking a doctoral program is a significant commitment involving sustained effort as an individual engages in academic work and scholarly identity formation. As a graduate student with a psychiatric disability, I face an added layer of challenge: dealing with symptoms as I navigate an academic system that is not designed for bodyminds like mine. This poetry and visual art collection offers a glimpse into my experience as a first-year doctoral student with schizoaffective disorder1 as I navigated Zoom classrooms, considered academic timelines and campus mental health awareness week, and wrestled with symptoms during the summer session. Through a schizo-poetic and visual inquiry informed by disability poetry and schizo-poetics, I present an embodied, multi-sensory exploration to highlight similarities and differences in the experiences of doctoral students with mental illness and their neurotypical peers, as well as to expand the conversation around disability and academia.
Colour Words (Hand-Made Visualisations of Literature)
Authors: Thompson Karen
Published: August 2023

In her making practice, Colour Words, Thompson represents the words used to describe colour in novels as embroidered squares on paper. In doing so, she creates alternate visualisations of literature, which has led to more questions, discoveries of patterns, and a new way of thinking about and relating to narratives and text/s. In this article, Thompson describes her making practice/process as an example of small data methodology and reflects on the experience to draw out meaning.
Nuts
Authors: Megan Smorschok
Published: August 2023

The following fairy tale is the creative output from an arts-based autoethnographic inquiry created in partial fulfillment for my Master of Arts degree. Inspired by the doctoral work of Lindsay Eales (2018), my main research objective was to challenge, (re)imagine, and transform conventional dance spaces into spaces that were more accessible for Mad bodyminds. I used artistic processes such as painting, dancing, and journaling to examine my own experiences of madness within and outside of dance spaces. I then took my findings and began writing an autoethnographic creative nonfiction piece in the form of a whimsical fairy tale that sought to deconstruct my personal experiences and reconnect them to other Mad works and texts. In doing so, my fairy tale is not only an imagination of the Mad-affirming dance spaces I wish were available to me throughout my dance career, it is an invitation to imagine Mad-affirming worlds beyond.
"The Long Shadow of a Juniper Berry"
Authors: Bartlett Stephanie
Published: August 2023

The purpose of this article is to focus on one land-based, poetic experience at the Blackfoot cultural site Aisinai’pi, Writing on Stone Provincial Park in Alberta, Canada. The focus is on an experience with two participants in the research, the Elder and the artist, who are both working with the school involved on this journey and me, the researcher. To situate the article as part of a research study, I also share the context of the broader qualitative study that works within an Indigenous paradigm to explore the development of kinship between children, the land, and each other. My question in this article is this: How do the poetics of land open new possibilities of how to cultivate a kinship ecology with children? I engage poetic inquiry and life writing to illuminate how this experience on the land gave meaning to and shaped the rest of the research study as it unfolded with children, teachers, an artist, and the Elder who guides the work.
It's All In the Details
Authors: Grimmett Helen
Published: August 2023

Patricia Leavy’s Re/Invention: Methods of Social Fiction presents a highly readable how-to guide to writing social fiction as an accessible and impactful form of research inquiry. Providing extensive background information on the development and purposes of the genre and then discussing examples from her own social fiction novels, Leavy not only teaches readers how to go about writing social fiction but also explains why this is a worthwhile thing to do. This book review creatively puts into practice what I have learnt through reading Re/Invention. Through a fictional recounting of a book club discussion about Leavy’s work, both the form and content of this review illuminate many of the key points, tips, and techniques on offer in this highly recommended primer
Frequency of drug-associated hyperprolactinaemia: a single-center retrospective study
Authors: GÜNEŞ Elif , GÜNEŞ Mutlu
Published: August 2023

Objectives: One of the causes of hyperprolactinaemia (HP) is drug-associated HP (DAHP). In this study, it was planned to investigate the frequency of DAHP.
Methods: In this study, a retrospective review of 296 individuals referred to the endocrinology outpatient clinic between June 2013 and March 2018 due to elevated prolactin (PRL) was performed.
Results: Of the 296 patients included in the study, 140 (47.3%) had HP (+), 80 (27.0%) had HP (-), 27 (9.1%) had DAHP and other causes (16.6%). The causes of DAHP were as follows; sulpiride in 7 (25.9%) patients, risperidone in 6 (22.2%), amisulpride in 4 (14.8%), domperidone in 3 (11.1%), haloperidol in 2 (7.4%), paliperidone, olanzapine, escitalopram, duloxetine and otilonium bromide in one patient each. PRL levels in the DAHP group were higher than in the HP (-) group (respectively; median 114.6 [interquartile range (IQR): 144.0], median 35 [IQR 37.3], p < 0.001). Patients with DAHP had an increased frequency of symptoms compared to the HP (-) group (oligomenorrhoea; 42.3%, 16.4%, p = 0.007, galactorrhoea; 53.8%, 30.1%, p = 0.028, respectively). PRL levels were higher and the frequency of clinical signs was higher in sulpiride than risperidone (PRL; median 195.0 [IQR 99.0], median 72.0 [IQR 57.9], p = 0.022, oligomenorrhoea; 100%, 20%, p = 0.010, respectively).
Conclusions: One of the 3 most common causes of patients referred for HP is DAHP and the most common cause of DAHP is anti-psychotic drugs. Sulpiride causes a higher rate of elevated PRL and frequency of clinical findings compared to other drugs.
NON-ALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH TYPE 2 DIABETES: MODERN IMAGING MODALITIES
Authors: Babenko A. Yu. , Laevskaya M. Yu. , Meltonian A. R. , Savchenkov Yu. N. , Trufanov G. E.
Published: August 2023

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide and one of the most common cause of liver transplantation in developed countries. Type 2 diabetes mellitus (T2DM) is an important risk factor for NAFLD. Additionally, T2DM is believed to accelerate the progression of NAFLD. Therefore, the use of different imaging modalities in this patient cohort appears to be more important than in patients with NAFLD without diabetes mellitus. Moreover, NAFLD is often overlooked in clinical practice. It should be noted that the gold standard for diagnosing NAFLD is still a liver biopsy, however, the method has a number of obvious disadvantages in terms of invasiveness, the impossibility of its frequent use in routine practice, its inapplicability for assessing the dynamics of NAFLD during treatment, and relatively high cost. In this regard, work is underway to find new non-invasive methods for diagnosing NAFLD, especially in the early stages. Radiation diagnosis of NAFLD is based on the use of ultrasound (ultrasound), computed tomography (CT) and magnetic resonance imaging (MRI), the sensitivity and specificity of which vary considerably. Thus, this review summarizes and discusses modern methods of non-invasive diagnosis of different types of NAFLD in patients with T2DM that can potentially have an important prognostic value.
DEVELOPMENT OF THE CONCEPT OF CARDIOVASCULAR RISK FACTORS FROM THE PERSPECTIVE OF TRANSLATIONAL MEDICINE
Authors: Sokolova L. A. , Gorlova I. A. , Omelchenko M. Yu. , Bondarenko B. B.
Published: August 2023

High cardiovascular mortality (CVD) determines the relevance of their effective primary and secondary preventive measures, based on the principles of a clinical-epideomyological approach and the isolation of risk factors (RFs). Until now, CVD have been the leading cause of deterioration in the demographic indicators of the population of all countries. According to WHO, they account for up to 31 % of deaths and up to 59 % of deaths. Adherence to the principles of a healthy lifestyle, a reduction of the main RFs at the population level can prevent up to 80 % of the premature CVD deaths. At the same time, clinical manifestations of atherosclerosis can arise in the absence of “classic” RFs. To improve CVD prediction results the possibility of using additional criteria, the so-called “new” RFs, is being studied. They include the accumulation of final products of glycation, insulin resistance, obesity and hyperhomocysteinemia. Insulin resistance and hyperhomocysteinemia are thougth to be of the most value for their integration in “classic” RFs of atherosclerosis and atherothrombosis in the diagnosis of CVD and assessing individual prognosis.Thus, the risk of CVD increases under the influence of a huge number of different genetic, anatomical, physiological,biochemical, psychoemotional factors, and the identification of markers for the development of CVD is an urgent problem of modern health care.
PECULIARITIES OF THE COURSE OF CARDIOVASCULAR PATHOLOGY IN SUBCLINICAL HYPOTHYROIDISM
Authors: Kuznetsova O. E. , Kruzhalin E. E. , Kutelev G. G. , Cherkashin D. V. , Nikashin A. N.
Published: August 2023

Primary hypothyroidism is one of the most common endocrine pathologies. Subclinical hypothyroidism (SH) is a common disorder diagnosed with elevated levels of thyroid-stimulating hormone (TSH) and normal serum free thyroxine (T4) levels. There are also the difficulties in diagnosing SH due to its low-symptomatic or asymptomatic course and numerous “masks”: cardiological, gastroenterological, rheumatological, hematological, psychiatric. A wide variety of causes also makes timely diagnosis difficult.There are many studies proving the effect of SH on the state of the cardiovascular system (CVS) and its association with a higher risk of cardiovascular events. Diastolic dysfunction and arterial hypertension (AH) are commonly observed. Of note, the issue of prescribing replacement therapy with Levothyroxine sodium is still controversial. It is necessary to conduct further research in order to develop unified algorithms for the treatment of patients with FH, including those with concomitant cardiovascular diseases (CVD).CVD is a frequent companion of hypothyroidism. The studies on FH replacement therapy are of low methodological quality and their conclusions on the outcomes of interest are not consistent. Thus, further studies with a large number of patients are required to identify the effect of FH on the state of the CVS.In this review, the authors summarize and present the available data on the incidence, pathogenetic mechanisms, cardiovascular pathology in HF, as well as its treatment.
Enhancing Teaching Skills: The Principal's Role in Implementing Convergence Clinical Model for Questioning Skills Improvement
Authors: Tiyas Nenin Maining
Published: August 2023

This study aims to describe holistically the role shown by the principal as a supervisor through supervision activities of the convergence clinical model to improve teacher teaching skills, especially questioning skills. This research uses a qualitative approach with a multi-case study design. The subjects of this research were SDN Dukuhklopo and MI Plus Darul Falah Jombang. Data collection instruments in this study used in-depth interview techniques, participant observation, and documentation studies. Data analysis is carried out together with the process of data collection and analysis after data collection is complete. The results of the study show (1) In planning supervision, the supervision program made by the principal of the school/madrasah includes efforts to improve questioning skills or learning competencies in general that need to be improved. Furthermore, the school principal socializes the supervision program with teachers. (2) Implementation of school/madrasah supervision begins with assessing the completeness of teaching tools and to improve questioning skills, supervisors carry out observations using instruments. (3) The follow-up of school/madrasah supervision is carried out, namely the follow-up on the results of the evaluation of teacher teaching tools and the results of supervision of class visits.
ADENOCARCINOME COLIQUE ET CARCINOME RENALE A CELLULES CLAIRES :UNE ASSOCIATION RARE :A PROPOS DUN CAS
Authors:   Service Dhepato-Gastro-Enterologie, CHU TTA, Hopital Mohamed VI, Universite Abdelmalek Saadi., Grihe L. , Meyiz H. ,   Service Dhepato-Gastro-Enterologie, CHU TTA, Hopital Mohamed VI, Universite Abdelmalek Saadi., Eljaadi I. ,   Service Dhepato-Gastro-Enterologie, CHU TTA, Hopital Mohamed VI, Universite Abdelmalek Saadi., Akjay S. Salhani A. ,   Service Dhepato-Gastro-Enterologie, CHU TTA, Hopital Mohamed VI, Universite Abdelmalek Saadi., Mellouki I. ,   Service Dhepato-Gastro-Enterologie, CHU TTA, Hopital Mohamed VI, Universite Abdelmalek Saadi.
Published: August 2023

Lassociation de tumeurs primitives synchrones a un cancer colorectal a fait lobjet de plusieurs publications. Elle peut survenir de maniere sporadique ou rentrer dans le cadre de syndromes cliniques bien definis tel que le syndrome de Lynch. Il sagit dune entite clinique rare mais reelle, dont lincidence est variable. La decouverte du carcinome renale est le plus souvent fortuite au cours du bilan dextension. Letiopathogenie nest pas completement elucidee incluant des facteurs de risques genetiques et environnementaux. Le traitement se base essentiellement sur la resection chirurgical generalement dans un seul temps, mais la decision doit Ãªtre prise dans une reunion de concertation pluridisciplinaire. Letude genetique savere necessaire pour mieux elucider letiopathogenie. Nous rapportons le cas dun homme age de 52 ans qui a simultanement presente un adenocarcinome colique et un carcinome a cellules claires renales, de decouverte fortuite au cours du bilan dextension du carcinome colorectal. Nous discuterons la pathogenie ainsi que le pronostic et le traitement de cette entite rarement decrite.
CALCIPHYLAXIS, ANOTHER FACET OF MASTITIS: A CASE REPORT
Authors: K. Ikouch , O. Wajih , Y. Benchrifi , S. Tossi , M. Benhassou , M. Ennachit , M. El Kerroumi
Published: August 2023

Introduction: Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare but dreaded condition in patients with chronic renal failure (CRF), whether they are on dialysis or not. Case report: A 67-year-old woman with a 10-year history of chronic renal failure, undergoing hemodialysis, presented with bilateral mastitis characterized by severe lancinating pain and non-healing tissue loss despite medical treatment with antibiotics and anti-inflammatory drugs. Mammography provided limited imaging findings. The diagnosis of calciphylaxis was established after bilateral surgical biopsy. Discussion: Calcific uremic arteriolopathy, or calciphylaxis, is a rare but life-threatening disease associated with chronic renal failure. Its diagnosis can be challenging. Skin biopsy is considered the gold standard for establishing the diagnosis, but it is not without risks. Recognizing typical skin lesions is important for initiating appropriate management. The management of these patients is multidisciplinary and involves several aspects. In certain cases, the clinical situation may not allow for a cure, and palliative care options will be proposed. Conclusion: Calcific uremic arteriolopathy is a dreaded condition that primarily occurs in patients with known chronic renal failure, whether they are on dialysis or not. The prognosis is very grim. It relies on a careful examination of the lesions and the exclusion of various differential diagnoses. A multidisciplinary approach is essential to prevent the progression of the lesions and facilitate healing.
LEVERAGING COMPUTER SCIENCE FOR ENHANCED CYBERSECURITY
Authors:   G.D Goenka Public School, Sector 48-Gurgaon., Singh Yajat
Published: August 2023

Currently, the majority of international economic, commercial, cultural, social, and governmental contacts and activitiesâ€”including those of people, non-governmental organizations, governments, and governmental institutionsâ€”are conducted online. Recently, cyberattacks and the risk of wireless communication technology have become issues for many commercial businesses and governmental institutions throughout the world. The modern society is heavily reliant on electronic technology, thus safeguarding this data from cyber-attacks is a difficult problem. The goal of cyberattacks is to financially hurt businesses. Cyberattacks may also serve military or political objectives in other circumstances. PC infections, knowledge gaps, data distribution services (DDS), and other attack vectors are a few examples of these harms. In order to protect harm from cyberattacks, numerous organizations employ a variety of measures. Researchers from all around the world have up till now offered a variety of techniques to stop cyberattacks or lessen the harm they inflict. Some of the approaches are now being used, while others are still being studied. The purpose of this study is to examine and thoroughly analyze the standard advancements made in the area of cyber security as well as to look into the difficulties, advantages, and disadvantages of the suggested approaches. The several new descendant assaults are discussed in depth. The history of early-generation cyber-security techniques are explored together with standard security frameworks. Additionally, new advancements in cyber security, security concerns, and dangers are discussed. It is anticipated that the thorough review study offered to researchers in IT and cyber security will be useful.
TENDENCIAS Y DESAFIOS DEL TRABAJO DESDE CASA EN EL SECTOR AGROPECUARIO POST-COVID-19: UN ENFOQUE EN EL PERSONAL ADMINISTRATIVO
Authors:   Doctor en Gestion Administrativa, Universidad Autonoma de Campeche, Av. Agustin Melgar s/n, Col. Buenavista, Campeche, Mexico., Guillermo Chuc Giselle , Manuel Patron Cortes Roger ,   Doctor en Gestion Administrativa, Universidad Autonoma de Campeche, Av. Agustin Melgar s/n, Col. Buenavista, Campeche, Mexico., Monserrat Llanes Chiquini Charlotte ,   Doctor en Gestion Administrativa, Universidad Autonoma de Campeche, Av. Agustin Melgar s/n, Col. Buenavista, Campeche, Mexico., Alberto Perez Canul Carlos ,   Doctor en Gestion Administrativa, Universidad Autonoma de Campeche, Av. Agustin Melgar s/n, Col. Buenavista, Campeche, Mexico., Manuel de Jesus Mex Alvarez Rafael ,   Doctor en Gestion Administrativa, Universidad Autonoma de Campeche, Av. Agustin Melgar s/n, Col. Buenavista, Campeche, Mexico.
Published: August 2023

With the purpose of establishing a relevant precedent for future situations that require the adoption of remote work, this study focuses on the implementation of tools, guidelines and strategic practices during the COVID-19 pandemic in a company in the agricultural sector. The experience of the administrative staff of the company in the Mexican Southeast in relation to the home office is examined. The main objective of this research is to propose improvements in the guidelines and practices of remote work applied in the administration of the company during the various stages of the contingency. The aim is to optimize the management of work from home and develop effective strategies to face future adversities related to the health and integrity of employees. This study is based on applied research with an exploratory and quantitative approach. A non-experimental and longitudinal design is used to examine the restrictions that the staff faced in terms of infrastructure, equipment and logistics to carry out their functions during the home office. The results present a management and continuous improvement proposal based on the experience acquired during the social isolation caused by the COVID-19 pandemic. This proposal aims to strengthen the control of adversities that may arise in situations of risk to the health and integrity of collaborators. The vision obtained from the employment situation confirms the importance of planning and administrative and economic forecasting in organizations. These processes increase the probability of efficiently and effectively addressing any event that requires modifying or adapting normality, as has been the case with remote work during the COVID-19 pandemic in companies in the agricultural sector.
SAVOIRS ET USAGES LOCAUX DE SCORODOPHLOEUS ZENKERI HARMS (FABACEAE) ET AFROSTYRAX LEPIDOPHYLLUS MILDBR (HUACEAE) EN ZONE FORESTIERE ET SAVANE HUMIDE AU CAMEROUN
Authors:   Faculte dAgronomie et des Sciences Agricoles, Departement de Foresterie, LAFAPSYTEB, Universite de Dschang Cameroun., Fomekong Fabrice Aurelien Nguegang , Marie Louise Avana ,   Faculte dAgronomie et des Sciences Agricoles, Departement de Foresterie, LAFAPSYTEB, Universite de Dschang Cameroun.,   Faculte dAgronomie et des Sciences Agricoles, Universite de Dschang Cameroun., Rene Bikomo ,   Faculte dAgronomie et des Sciences Agricoles, Universite de Dschang Cameroun., Etchike Alex Dong ,   Faculte des Sciences, Universite de Dschang Cameroun.
Published: August 2023

In the forest zone of Central Africa in general and Cameroon in particular, medicinal and food plants constitute the most important category of NTFPs, and many medicinal species contribute to income, cultural identity and improved well-being in rural and peri-urban households. Among these NTFPs, S. zenkeri and A. lepidophyllus, with their multiple uses, remain very useful plants for socio-cultural groups. The aim of this study was to inventory local knowledge and management practices according to ethnic groups and agro-ecological zones in Cameroon. The study was conducted in two agro-ecological zones (Savannah and Forest). Semi-structured individual interviews were conducted with 138 people involved in the S. zenkeri and A. lepidophyllus value chain. The non-parametric Kruskal-Wallis test was used to compare the different variables. Six ethnic groups were surveyed. The organs (S. zenkeri and A. lepidophyllus) used by these ethnic groups were seeds, barks, leaves and roots. Three main categories of use were recorded (food, medicinal, commercial) according to these organs. The seeds were used more for sale and self-consumption, while the barks, leaves and roots of S. zenkeri and A. lepidophyllus were used to treat 17 and 12 illnesses and symptoms respectively, including headaches, stomach ache, toothache, coughs and aches, etc. Despite its many uses by different ethnic groups, the species is subject to various anthropogenic pressures and benefits very little from conservation measures. Previous research should focus on its sylviculture to ensure its domestication.
STANDARD OPERATING PROCEDURE (SOP) OF MOSQUE AND SURAU ACTIVITIES DURING CONDITIONAL MOVEMENT CONTROL ORDER(CMCO)INPENINSULAR MALAYSIA: STUDY IN SELANGOR AND MELAKA
Authors:   Academy of Contemporary Islamic Studies, UniversitiTeknologi MARA., Khurshiah Mohd Mansor Siti , Abd Rahim SyuhaidaIdha ,   Academy of Contemporary Islamic Studies, UniversitiTeknologi MARA., Hidayah Zainal Nur ,   Academy of Contemporary Islamic Studies, UniversitiTeknologi MARA., Shukor Mohd Ali Abdul ,   Academy of Contemporary Islamic Studies, UniversitiTeknologi MARA., Abdullah Akmalizabt ,   Faculty of Social Science and Humanities, UTM Skudai, Johor.
Published: August 2023

The COVID-19 pandemic that hit the world at the end of 2019 has changed peoples lives, including the worship matters for Muslims. To prevent the pandemic that has caused millions of deaths from spreading, the Malaysian government has implemented a series of Movement Control Orders (MCOs) by introducing various Standard Operating Procedures (SOPs) that all Malaysians must adhere to. During this MCO period, the prohibition of worship activities carried out in mosques and Surau involving gatherings of many Muslims has triggered various community reactions. Some of them are dissatisfied when the limit on the number of jamaah allowed to attend is very small and varies by state. Therefore, this study aims to identify the SOP setting method used by two states namely Selangor and Melaka. These two states were selected based on the significant differences between the two states in terms of the limit on the number of jamaah allowed to attend mosques and Surau. Interviews with SS Mufti of Selangor and Melaka were conducted to obtain data on the question of this study. The findings from this study show that the difference between SOPs issued is to look at the situation during the ongoing infection cases. The situation and the level of dharurah (harm)or masyaqqah(hardship)that occurs is the basis of the setting of an SOP so that harm can be prevented and controlled from continuing to be rampant to preserve the maqasid syariah of the protection of human life.