bluuebunny/crossref_metadata_2025 huggingface dataset:
CURRENCY WAR- REASONS AND REPERCUSSIONS
Authors: Bahri Pranjal  .
Published: February 2023

Currency war or competitive devaluation is a situation in which countries try to gain a trade advantage over other countries by causing the exchange rate of the domestic currency to fall in relation to other currencies. Every country would want to prosper, but why does it depreciate its currency? There are 3 reasons: Firstly, to boost the exports. Secondly, to reduce the trade balance deficit and thirdly to reduce the debt burdens. It is a global phenomenon and has various positive and negative impacts. For developing countries, it is a loss situation at the time of implementation of currency and loss of competitiveness as well as removal. It might sound different, but a strong currency necessarily does not serve in a nation's best interests. Today value of one dollar is equal to seventy rupees. If India wants it could bring down the value of dollar in comparison to rupees by tweaking its economic policies, but this will reduce India’s profit which it earns from various sources such as IT exports, FDI, Tourism etc. Therefore, India does not appreciate its currency and likewise every country has its system. This paper with through light on why currency war is there and what will be its repercussions on us
CONTRIBUTIONS OF ROYAL MUGHAL WOMEN IN ECONOMIC FIELD
Authors: Kumar Dinesh , Mandot Dinesh
Published: February 2023

Women occupy a critical place in every stratum and society. Royal Mughal ladies played a considerable role in the economic field during the Mughal period. The Mughal age was marked by overall prosperity and growth in all the spheres of life. There was hectic economic activity in the country, which led to growth of trade and commerce. India commodities like textiles, spices, and exotic products like opium and dyes were in great demand in the countries of west Asia and North Africa. The items of import were gold, silver, ivory, pearls, precious gems, horses etc. Mughal women made a fairly large but little appreciated contribution to the development of trade and commerce in the country. Besides participating in economic activities, Mughal royal ladies saw to the construction of markets and caravan sarais. Therefore, encouraging and faciliating trade conditions in the country. The present article deals with contribution of the royal Mughal ladies in economic property of the Mughal empire which occupies a unique place in the annals of India.
A STUDY OF SOCIAL MEDIA ADDICTION AND ITS INFLUENCE ON PSYCHO-SOCIAL BEHAVIOR AMONG B.ED TRAINEES
Authors: Bhatt Deepika . , Upreti Prakash Chandra
Published: February 2023

With rapid digitalization, the use of social -media is increasing in our lives. It has become fourth meal of the day. Young or old no one is left behind who may not have used any of the social media platforms. This study was set out to determine social media addiction and it’s influence on parent- child interaction and social-interaction and behaviour among B.Ed. trainees. The study was conducted with 70 students enrolled in B.Ed. training programme of Government colleges in Kumaun University. For the data collection a structured interview schedule on social media addiction, parent-child interaction and social interaction and behaviour were used. The results showed that students have a moderate to high level of addiction. 56% of them usually spend 5-7 hours each day on social media. They check their phones while at study or work as well. 78% accepted, they keep on checking social media account when they talk with friends and colleagues. Only 50% of them spend 3-5 hours with parents daily and carry phone while having meal with their family. And when in stress 45% prefer to spend time alone than to have time with friends and 30% use social media to hang upon. Most of them use social media for their leisure and personal socialization and when they get free time are pre-occupied with phones.
PROJECTION OF WOMEN IN NAIPAUL’S INDIAN TRAVELOGUES
Authors: Chaudhary Ankita  . , Sharma Gaurav .
Published: February 2023

This paper seeks to represent the Indian women in V.S. Naipaul’s Indian travelogues – An Area of Darkness, India: A Wounded Civilization, and India: A Million Mutinies Now. Naipaul’s three books on India are not only a discourse of a diasporic individual who returns to his ancestral land to re-establish the severed ties with the homeland, but it is also a cultural, social, political, and economic representation of India towards the end of the nineteenth century. While portraying the lives of Indians in these three books, Naipaul has also portrayed how Indian women cope with the changing society. Through years of discrimination and subjugation holding them back, Indian women gradually stand up against the patriarchal society, and Naipaul’s on his three books on India record how these women cope with the changing societal norms.
आधुनिक संप्रेषण ; सूचना कौशलद्ध के विकास में सांवेगिक बुद्धि की उपादेयता
Authors: सिंह उम्मेद  .
Published: February 2023

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FEMALE GENITAL MUTILATION: A SOCIO-LEGAL PERSPECTIVE IN INDIAN CONTEXT
Authors: Sahebrao Ghadge Snehal
Published: February 2023

Youngsters and also the ladies have been exploited everywhere around the globe in one way or another, several ways in which are overtly followed against them whereas some are deeply coated behind the curtains, feminine reproductive organ Mutilation(FGM) is one such grotesque method of exploitation of young women. The practice refers to the forceful cutting or manipulation of the private parts of young girls in the name only of cultural and spiritual beliefs. It reflects the deep-seated difference between the sexes and constitutes an extreme kind of discrimination against women. This paper is aimed toward explaining the meaning and therefore the} procedures and techniques concerned during this derogative follow together with the harmful effects that it's on the life and dignity of the people and the reasons behind its prevalence within the society. The paper also deals with the position of this practice in Asian countries and internationally. it's nearly continuously administrated on minors so may be a violation of the rights of children. The practice is aimed at gender inequality and tries to manage women's sexuality, and concepts concerning purity, modesty, and beauty. This paper is an endeavor to spotlight the hidden existence of this life-threatening practice behind the curtain of culture and faith in India.
झारखंड के पत्रकारिता का इतिहास
Authors: कुमार चंदन  .
Published: February 2023

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REVIEW ON CYANIDE POISONING
Authors: Dhanvijay Snehankita V. , Gawali Vaibhav . , Dhanvijay Nivedita .
Published: February 2023

Cyanide is one of the most lethal poison. It leads to death within a few minutes to a few hours sometimes. Depending upon the dose and route of administration or exposure the symptoms develop. The area of exposure is manufacturing and industrial sources such as insecticides, photographic solution, fumigation and electroplating work, plastic manufacturing and jewelry cleaners etc. History shows the common use of cyanide poisoning in suicidal and homicidal cases and also use as chemical warfare agent for terrorist attack. Incidence of cyanide poisoning is rare but the occurrence of death is seen instant in some cases. It causes histotoxic anoxia and inhibits oxidative phosphorylation, a process where oxygen is utilized for the production of essential cellular energy sources in the form of ATP. It does so by binds to the enzyme cytochrome C oxidase and blocks mitochondrial transport chain. This results in cellular hypoxia and the depletion of ATP occur, leading to metabolic acidosis. Symptoms such as headache, dizziness, vertigo, spasmodic closure of jaw and clawing of hands, tonic type of convulsions of the limb and trunk, muscular weakness and flaccidity, muscular paralysis, intense cyanosis, hypertension followed by hypotension, coma etc leads to death. Death is mainly due to cardiovascular failure and respiratory failure. Thus, rapid treatment to be started in such patients. The 100 % oxygen support and rapid therapy of antidotal treatment is necessary for life saving. Very efficient antidote is Hydroxocobalamin and other antidotes are also important in cyanide poisoning in the treatment as life saver. Survivors of cyanide poisoning may develop neuropathies.
INVESTIGATION ON SMARTPHONE ADDICTION LEVEL AMONG STUDENT-TEACHERS
Authors: Shantha G. , Saila T. Sahaya
Published: February 2023

This study aimed to examine Smartphone addiction level, and the predictive factors of the Smartphone addiction in B.Ed. Programme student-teachers in Chennai. Survey method is used to select a sample of 300 students at the student-teachers. The research tools used are Smartphone addiction scale, developed and standardized by Dr. Vijayshri and Dr. Masaud Ansari is used for this study. This scale consists 23 items divided into six dimensions namely, Compulsion, Forgetfulness, Lack of Attention, Depression and Anxiety, Disturbed Hunger/Sleep and Social Withdrawal. The results of the statistical analyses show there is no significant difference between male and female student-teachers in the level of Smartphone addiction. There is significant difference between the student-teachers based on their educational level and internet access in Smartphone addiction. This study suggests that the student-teachers should reduce the intense use of Smartphone for smoothly doing their daily-life activities.
भारत में माध्यमिक शिक्षा प्रणाली एक विश्लेषण
Authors: सिंह मनोज  कुमार
Published: February 2023

प्रस्तुत लेख भारत में माध्यमिक शिक्षा प्रणाली पर किये गए शोध पर आधारित है। यह लेख माध्यमिक शिक्षा प्रणाली पर शिक्षा आयोगों द्वारा दिये गये सुझावों को ध्यान में रखते हुए उसकी कार्य प्रणाली तथा प्रणाली में सुधार को लेकर केंद्रित हैं ।
IMPACT OF PARENTING STYLE AND PEER PRESSURE ON CRIMINAL PROPENSITY AMONG MALE AND FEMALE YOUNG ADULTS
Authors: Fahim Aquamsha , Dangwal Pragyan
Published: February 2023

This paper attempts to study the effect of Parenting Style and Peer Pressure on Criminal Propensity of Young Adults and also attempts to explore whether there exists a gender difference. The research design used is Ex-Post Facto Research Design, Correlational in nature. The study consisted of 150 young adults, 83 males and 67 females, between the age ranges of 17 to 24 years belonging to Lucknow city. The results reveal that Authoritarian Parenting Style is significantly associated with high criminal propensity and Peer Pressure had no significant effect on criminal propensity of Young adults. However, none the variables predicted criminal propensity. The study found no significant gender difference on criminal propensity, parenting style or peer pressure.
ACADEMIC ACCESSIBILITY, AN IMMERGING CONCEPT
Authors: Bhole Dhananjay , Sonawane Sanjeev
Published: February 2023

Inclusion of persons with disabilities and other marginalized section of human society in education is increasingly gaining importance in all part of globe. Access to Academic program, Services and activities is Crucial part of inclusive education. Academic accessibility is one of the important concept of inclusive education which is needed to be understood by all the stakeholders of academics who are conducting research in the area of Inclusive Education and Accessibility of education system for persons with disabilities. Need is being realized to study all the aspects of accessibility of education system that includes Accessibility of Academic web services, Accessibility of Academic built environment, Accessibility of Academic course content and Accessibility of course delivery mechanism. This paper presents concept of Academic accessibility in detail. All the components of Academic accessibility are presented systematically with its relevance on each other. It also covers Laws, Standards, guidelines and policies related to academic accessibility. The paper concludes with the presentation of institutional cases on academic accessibility and usability of the concept in Inclusive education.
INTERPRETATION OF SOCIAL SCIENCE TEXTS: TEACHER AND THE CLASSROOM
Authors: Dedhwal Nisha
Published: February 2023

The given work is an attempt to analyze how social science textbooks based on NCF 2005 with the proposed epistemic shift in the approach of teaching of social sciences have been able to represent a scope for change. More specifically the given paper analyzes the interpretation 0f social science texts to bring in the importance of text book analyses with the purpose of exploring textbook as tool for change. It suggests how the interpretation of social science texts may provide a scope for understanding the changing role of textbooks in classroom teaching learning process. Keeping the proposed epistemic shift in mind, analysis of the concept of citizenship in the series of Social Political Life NCERT textbooks in comparison to colonial Civics, the given paper attempts to give new insights in the vision of pedagogy of Social Science.
भारत में ग्रामीण विकास कार्यक्रमों का जीवन की सामाजिक-आथर््िाक गुणवत्ता पर प्रभाव (उ0 प्र0 के जनपद मैनपुरी के विषेश संदर्भ में)
Authors: यादव तेश  कुमार , रंजन कुमार  राजीव
Published: February 2023

ग्रामीण एवं निम्न वर्ग के जीवन की सामाजिक-आर्थिक गुणवत्ता में सुधार लाने के लिये भारत सरकार ने सम्पूर्ण राष्ट्र में विभिन्न योजनाओं का शुभारम्भ किया गया है। वर्श 2018 में एम.एस.डी.आई. ने प्रधान मंत्री कौषल केन्द्र , पी.एम.क.ेवी.वाई. के अन्तर्गत कौषल विकास प्रषिक्षण के लिए उद्योग मानकीकृत बुनियादी ढांचों के निर्माण के लिए बडे पैमाने पर ध्यान केन्द्रित किया। प्राथमिक तथ्यों के विष्लेशण से ज्ञात हुआ है कि ग्रामीण विकास के अन्तर्गत ग्रामीण क्षेत्रों के बहुमुखी विकास (शिक्षा, रोजगार, कृषि, निर्धनता, स्वच्छता, स्वास्थ्य) एवं जीवन की गुणवत्ता सुधार के लिए भी इन योजनाओं का आषातीत सहयोग रहा है। सरकारी विकास योजनायें; निर्बल वर्ग के जीवन की गुणवत्ता एवं षिक्षित बेरोजगारों के सामाजिक आर्थिक उत्थान में सहायक हैं।.
STUDIES ON ANTIMICROBIAL ACTIVITY OF MEDICINAL PLANTS AGAINST HUMAN PATHOGENS
Authors: R. Sontakke M. , Bodke S. S.
Published: February 2023

The Indian folk medicine practice is based on the use of plant extracts. Many phytochemicals like alkaloids,flavonoids,steroids, phenolics, terpenoids and saponins are isolated from the roots of medicinal plants like Ruellia tuberosa L. and Alangium salvifolium (L.F.) Wang. The plant and plant products are known for their therapeutic uses from thousands of years. In folk medicine it has been used as diuretic, Antipyretic, antidiabetic and analgesic agent. The plants are being used as medicinal plants as it is effective against many infectious diseases. The Ruellia tuberosa L. of family Acanthaceae and Alangium salvifolium (L.F.) of family Alangiaceae were studied for its antibacterial properties against pathogenic bacteria . During the present study Aqueous and Methanolic extract of roots of Ruellia tuberosa L. and root extract of Alangium salvifolium (L.F.) are used. Root extracts were evaluated for their antibacterial activity. The antibacterial study was carried out by disc diffusion method against the pathogens Klebsiella pneumoniae, Staphylococcus auerus, Salmonella typhi, Proteus vulgaris and Pseudomonas aeruginosa, and Escherichia coli. To evaluate the antibacterial activity methanol and aqueous extracts were used. The maximum zone of inhibition was observed in methanol extract as compared to aqueous extract for each bacterium was as Methanolic extract of roots of medicinal plants showed the zone of inhibition against the studied bacteria were S.typhi (12 mm), K. pneumoniae (15 mm), Proteus vulgaris (22 mm), Pseudomonas aeruginosa (18 mm) and Staphylococcus aureus(14 mm), and Escherichia coli.(12 mm).The present study demonstrates that the selected medicinal plants have antibacterial potential.
A STUDY ON EMPLOYEE ENGAGEMENT PRACTICES: A CASE APPROACH
Authors: Khan Tanaaz
Published: February 2023

Employee Engagement is just as critical for both workers and additionally the business. All real associations concur that there is an association between employee engagement and productivity increment through engaging employees in the workplace which prompts increment in yield, expanded deals, purchaser joy, and representative maintenance. Employee engagement is imperative keeping in mind the end goal to shape an enthusiastic association in the middle of representatives and the organization which affects their state of mind towards the organization's customers, and along these lines, it also enhances consumer loyalty and administration levels. This paper attempts to understand the concept and significance of Employee engagement. It further aims to present the case of Sidmak Laboratories (I) Pvt. Ltd. with reference to the Employee Engagement Practices. A Case study approach was conducted with the help of an independent study done at Sidmak Laboratories by the Researcher as an Internship project. Employee Engagement is pretty essential for Human Resources, an engaged employee potentially performs better than a non-engaged employee. Various engagement practices at the Organisation helps the Human Resources to engage further and contribute better.
MORNING ASSEMBLY AS AN IMPORTANT PART OF CURRICULUM
Authors: Parry Shabir Ahmad , Wani Umar Iqbal
Published: February 2023

The school's morning assembly provides a cool and disciplined beginning to the day's usually busy programme. It might be a way to convey and transform significant knowledge and ideals to the pupils. It provides a time of meditation before the workday begins, the school community gathers, and the assembly turns into a vehicle for addressing significant things to one another. The aim of this study is to emphasise the importance of morning assembly and the role of head masters, physical teachers in organising and maintain morning assemblies in schools. The concept of morning assembly is mentioned at the start of the article followed by importance, role of headmaster and physical education teacher and then suggestions how to conduct morning assembly.
HEALTH CARE FACILITIES AND INFRASTRUCTURE FOR PUBLIC HEALTH CARE SERVICES (AN OVERVIEW OF MUNICIPAL CORPORATION AREA DISTRICT AGRA, U.P.)
Authors: Gupta Anshul , Ranjan Kumar Rajeev
Published: February 2023

Health is directly connected with the welfare of the human being as this sector is the most important social service sector. The key focus of this sector is to reap the demographic dividend to produce healthy workforce and do social welfare of a State. The JandK performed very well in providing medical and health amenities to the people, but it is still below the satisfaction level. The development of health infrastructure in the state is measured through health infrastructure i.e., availability of dispensaries, doctors and hospitals. The State shows good outcomes in Crude Birth Rate, Institutional Births, life expectancy and Infant Mortality Rate. Government is running various programs to ensure the health care facilities and infrastructure for public health care but there is lack of the resources and manpower as per requirements. The population of India is the main hindrance on the way to ensure public health cares.
STUDY OF SOCIAL COMPETENCE IN RELATION TO SELF ESTEEM AMONG SCHOOL STUDENTS
Authors: . Jyoti , Devi Sharmila
Published: February 2023

Education is a lifelong process which is attained by an individual from its immediate surroundings. It helps a person, not only in professional success but also in social adjustments. These adjustments or adaptations are an integral part of human development, known a social competence. A socially competent person tries to understand the needs of self, others and further leads to the upkeep of a civilization. In today’s world, people are more engaged in themselves and hence, social relationships have become imperative for their own growth and happiness. Social competence ability might boost up multiple traits such as self confidence, motivation, cooperation, conflict resolution, and self esteem among children in their developing years. Therefore, the present study aimed to study the relationship between social competence and self esteem of senior secondary school students. Results revealed that senior secondary school students do not differ significantly in the scores of social competence and self esteem in terms of their gender. A positive and significant correlation was found in social competence and self esteem of senior secondary school students.
Hypoglycemia Detection Using Hand Tremors: Home Study of Patients With Type 1 Diabetes
Authors: Jahromi Reza , Zahed Karim , Sasangohar Farzan , Erraguntla Madhav , Mehta Ranjana , Qaraqe Khalid
Published: February 2023

Background

Diabetes affects millions of people worldwide and is steadily increasing. A serious condition associated with diabetes is low glucose levels (hypoglycemia). Monitoring blood glucose is usually performed by invasive methods or intrusive devices, and these devices are currently not available to all patients with diabetes. Hand tremor is a significant symptom of hypoglycemia, as nerves and muscles are powered by blood sugar. However, to our knowledge, no validated tools or algorithms exist to monitor and detect hypoglycemic events via hand tremors.

Objective

In this paper, we propose a noninvasive method to detect hypoglycemic events based on hand tremors using accelerometer data.

Methods

We analyzed triaxial accelerometer data from a smart watch recorded from 33 patients with type 1 diabetes for 1 month. Time and frequency domain features were extracted from acceleration signals to explore different machine learning models to classify and differentiate between hypoglycemic and nonhypoglycemic states.

Results

The mean duration of the hypoglycemic state was 27.31 (SD 5.15) minutes per day for each patient. On average, patients had 1.06 (SD 0.77) hypoglycemic events per day. The ensemble learning model based on random forest, support vector machines, and k-nearest neighbors had the best performance, with a precision of 81.5% and a recall of 78.6%. The results were validated using continuous glucose monitor readings as ground truth.

Conclusions

Our results indicate that the proposed approach can be a potential tool to detect hypoglycemia and can serve as a proactive, nonintrusive alert mechanism for hypoglycemic events.
Technology, Training, and Task Shifting at the World’s Largest Mass Gathering in 2025: An Opportunity for Antibiotic Stewardship in India
Authors: Chan Isaac H Y , Gofine Miriam , Arora Shitij , Shaikh Ahmed , Balsari Satchit
Published: February 2023

The role of antibiotic overuse in intensifying selection pressures and contributing to the emergence of antimicrobial resistance is well established. The Kumbh Mela, a religious festival that occurs in 4 Indian cities of spiritual significance, is the world’s largest mass gathering, attracting over 80 million pilgrims in 2013. Digital syndromic surveillance from the 2013 and 2015 Melas demonstrated a consistent pattern of antibiotic overuse, with an antibiotic prescribing rate of up to 31% for all patient encounters. As preparations for the 2025 Kumbh Mela begin, task shifting, point-of-care diagnostic and digital tools, robust clinician training, and community awareness can promote the restrained and evidence-based use of antibiotics, minimizing the potential for the emergence of antimicrobial resistance at the world’s largest mass gathering.
Barriers to and Facilitators of Older People’s Engagement With Web-Based Services: Qualitative Study of Adults Aged >75 Years (Preprint)
Authors: Money Annemarie , Hall Alex , Harris Danielle , Eost-Telling Charlotte , McDermott Jane , Todd Chris
Published: February 2023

BACKGROUND

The COVID-19 pandemic has accelerated the shift toward the digital provision of many public services, including health and social care, public administration, and financial and leisure services. COVID-19 services including test appointments, results, vaccination appointments and more were primarily delivered through digital channels to the public. Many social, cultural, and economic activities (appointments, ticket bookings, tax and utility payments, shopping, etc) have transitioned to web-based platforms. To use web-based public services, individuals must be digitally included. This is influenced by 3 main factors: access (whether individuals have access to the internet), ability (having the requisite skills and confidence to participate over the web), and affordability (ability to pay for infrastructure [equipment] and data packages). Many older adults, especially those aged >75 years, are still digitally excluded.

OBJECTIVE

This study aims to explore the views of adults aged >75 years on accessing public services digitally.

METHODS

We conducted semistructured qualitative interviews with a variety of adults aged ≥75 years residing in Greater Manchester, United Kingdom. We also interviewed community support workers. Thematic analysis was used to identify the key themes from the data.

RESULTS

Overall, 24 older adults (mean age 81, SD 4.54 y; 14/24, 58% female; 23/24, 96% White British; and 18/24, 75% digitally engaged to some extent) and 2 support workers participated. A total of five themes were identified as key in understanding issues around motivation, engagement, and participation: (1) “initial motivation to participate digitally”—for example, maintaining social connections and gaining skills to be able to connect with family and friends; (2) “narrow use and restricted activity on the web”—undertaking limited tasks on the web and in a modified manner, for example, limited use of web-based public services and selected use of specific services, such as checking but never transferring funds during web-based banking; (3) “impact of digital participation on well-being”—choosing to go to the shops or general practitioner’s surgery to get out of the house and get some exercise; (4) “the last generation?”—respondents feeling that there were generational barriers to adapting to new technology and change; and (5) “making digital accessible”—understanding the support needed to keep those engaged on the web.

CONCLUSIONS

As we transition toward greater digitalization of public services, it is crucial to incorporate the perspectives of older people. Failing to do so risks excluding them from accessing services they greatly rely on and need.
‘A pretty sublime mix of WTF and OMG’. Four explorations into the practice of evaluation on online book reviewing platforms
Authors: Boot Peter
Published: February 2023

The article uses a corpus workbench (Sketch Engine) to investigate practices of evaluation in online book reviews. The reviews were taken from Goodreads, Amazon, bol.com and a number of Dutch online book discussion platforms. We look at tools that have been used to study online book reviews. Then we investigate our own collection of reviews. Findings suggest (1) that online reviews are not just centred on the reviewers’ experiences but include solid discussion of the merits of books; (2) that reviewers of suspense prefer plot and character while reviewers of literary books prefer style and story; (3) that literal and metaphorical phrases referring to the body are often used in describing positive reading experiences; and (4) that positive reviews recount parts of the story, while negative reviews try to explain why the book was a disappointment.
Crypto Using Web 3.0
Authors: Nannware Shubhangi , Mahajan Dhiraj , Pingale Shrikrishna , Jadhav Neha , Goplani Prof. Shuchi
Published: February 2023

Abstract: Web 2.0 and now Web 3.0 has created great heights in the face of the Internet industry. The distance from Web 1.0 to Web 2.0 has been covered for almost a decade. But soon after Web 2.0 a new Web 3.0 evolved which has not only raised the level of interest but also many questions among developers, users, and regulators. Do we need it at this stage, what are the forcing factors, how it is different from Web 2.0 and the Semantic Web, what are its social, moral, and security implications, is it only about personalization, all these questions have made Web 3.0 popular among its stakeholders. In this paper, the primary focus will be on the relationship between Web 2.0, Web 3.0, and the Semantic Web while the second will be on the rising security concerns about rapid and sequential Web developments. However, the changing business models in the future of Web 3.0 will also be highlighted
Non-Extendability of Special DIO 3-Tuples Involving Nonaganal Pyramidal Number
Authors: Vidhya S , Gokila T
Published: February 2023

Abstract: This paper concerns with the construction of three distinct polynomials with integer coefficients (a1, a2, a3) such that the product of any two contribution of the set subtracted to their sum and improved by a non-zero integer (or a polynomial with integer coefficients) is a perfect square and this shows the non-extendability of Special Dio Quadruple
Community Space using WebRTC
Authors: Ansari Mohd Ilmaan , Junaid Mohd
Published: February 2023

Abstract: Human interaction is important in today's internet-based world. To effortlessly approach each other to communicate people can use the new technology i.e. web real-time communication (WebRTC). Our real-time communication system will provide virtual voice rooms to users to audio chat in groups or peer to peer using technologies like WebRTC, Node.js, Web Sockets and React.js. On the basis of a range of topics, users can create public/private rooms and join them as well. The implications of this study are better than the previous projects
Characterization, antibacterial and anticancer study of silk fibroin hydrogel
Authors: Singh Vandana , Srivastava Devika , Pandey Prashant , Kumar Mukesh , Yadav Sachin , Kumar Dinesh , Venkatesh Kumar R.
Published: February 2023

Purpose: Protein-based hydrogels such as silk fibroin hydrogel, are used in tissue engineering and regenerative medicine applications as they showed striking characteristics like biocompatibility and offered various benefits as biomaterials. The current study sought to prepare silk fibroin hydrogel and characterise it in order to assess its antibacterial and anticancer activity.

Methodology: Silk fibroin hydrogel was prepared and characterized by using different microscopy methods, namely Scanning Electron Microscopy (SEM), Phase Contrast Electron (PCM) microscopy, and foldscope analysis. Further, it was characterized through 1H-NMR analysis, Fourier Transform Infrared spectroscopy (FTIR) analysis, and swelling properties. A Current study also covers an antimicrobial and anticancer analysis of silk fibroin hydrogel by disk diffusion method and SRB (Sulforhodamine B) assay respectively.

Results: The antibacterial study confirmed that SF hydrogel has a moderate antibacterial activity for Streptococcus mutans, and Salmonella typhi. Additionally, the SRB assay test showed that silk fibroin hydrogels had moderate anticancer activity against the human lung cancer cell line (A549).

Conclusion: The current study unequivocally demonstrates that silk fibroin hydrogel has antibacterial and anti-cancerous properties, making it a suitable scaffold for future studies that seek to target a specific drug delivery site.

Keywords: Silk fibroin; Swelling behaviour; Anticancer; Drug carrier; Wound healing
Assessment of the Physico-Chemical Conformity of an Antiseptic Solution: Case of Polyvidone - Iodine 10%
Authors: CISSE Mody , BADIAGA Mamadou , DEMBELE Ousmane , OUATTARA K. Ibrahim , SANGARE Coumba Dite Astan , COULIBALY S. Moussa , SANGARE Modibo , TRAORE Nah , KOUMARE Y. Bénoit
Published: February 2023

Introduction: Antiseptics have been used for many years in human and veterinary medicine. Over the years, the lengthening of surgical procedures in human surgery and the increasingly frequent use of inert material has increased the risk of infections. This was why skin antisepsis has become very important in the prevention of infections of the surgical wound and resulting complications. In Mali, at the Gabriel Touré University Hospital, the most prescribed family of antiseptics was the halogenated ones, in particular 10% povidone iodine for wound and surgical site antisepsis. This study was aimed to control the quality of 10% povidone iodine used in the hospital. Methodology: We conducted at the Medicines Quality Control Service of the National Health Laboratory of Mali (LNS) a retrospective analytical study on the quality control of 10% povidone iodine. We obtained 10% povidone iodine samples from the Pharmacie Populaire du Mali (PPM). We analyzed 48 batches of samples in regards of visual inspection, average volume, titrimetry, colorimetric test and pH control. Results: All 48 analyzed batches were compliant, i.e. contained the active ingredient and could be used in health facilities or at home as an antiseptic. Conclusion: All analyzed batches of 10% povidone iodine samples did not show any cases of inconsistency and therefore could be used in the management of wound dressings. Future Direction: Use other analytical methods like HPLC to test the quality control of povidone and other types of antiseptics.

Keywords: antiseptic, povidone-iodine 10%, compliance, quality control
Transdermal Drug Delivery Systems
Authors: Pasupuleti Prakash , Bandarapalle Kishore , Sandhya Cherlopalli , Neeraja Gundam , Afzal Chilakala , Venkataramana Chithrala , VenkatSai Golla
Published: February 2023

A transdermal patch is a medicated adhesive patch that is applied to the skin that contains medication that is intended to be absorbed into the bloodstream. This frequently encourages the healing of a body part that has been hurt. Transdermal medication delivery allows for regulated drug release into the patient, resulting in less systemic side effects and, in certain cases, increased efficacy over other dose forms. This is an advantage of transdermal drug delivery over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. Transdermal medication delivery allows for a constant blood level profile, a regulated drug release into the patient, fewer systemic side effects, and other benefits.

Keywords: Transdermal patch, Blood stream, Systemic side effects.
Effect of the combination of Silybrum marianum and Lycopodium clavatum on some biological markers for monitoring chronic hepatitis B virus patients
Authors: ZEMO FOKOU Thierry Anicet , KANIA Dramane , TCHAKOUNTE Constantin , NYEGUE Ascension Maximilienne
Published: February 2023

Viral hepatitis B is a disease for which no curative treatment is available to date. The objective of this study is to evaluate the effect of Silybrum marianum and Lycopodium clavatum preparations on the biological parameters of viral hepatitis B follow-up.

Material and methods: This was a longitudinal study of a period of 5 months. The study population consisted of consenting chronic hepatitis B patients. A questionnaire was used to collect sociodemographic information and medical history of the patients. One Step Rapid Test HBV-2210305 and Biolabo kits were used to test for serological parameters and transaminases. The viral load was determined using the real-time PCR technique. The decoctions were made from the leaves and rhizomes of Sylibum marianum associated with the floral juice of Lycopodium clavatum. The evaluation of the effect of the decoction was done by comparing the values of parameters between the beginning and after 3 months of treatments.

Results: Seven out of nine patients were chronically infected with the hepatitis B virus in active phase. After 90 days of treatment, we noted the persistence of AgHbs in all patients but a disappearance of AgHbe in 75% of patients.  Mean transaminase activity and viral load decreased significantly after treatment (P=0.045).

Conclusion: The preparation of a decoction of Silybrum marianum and Lycopodium clavatum leads to normalization of Alanine Amino transferase activities (AAT), loss of HBe antigen and decrease of viral load after three months of treatment.

Keywords: Chronic hepatitis B, Silybrum marianum, Lycopodium clavatum, decoctions, transaminase activity and viral load.
A Case Report on Pulmonary Tuberculosis Associated with Deep Vein Thrombosis
Authors: Behera Sunil Kumar , Ali Syed Shoeb , Kummari Apoorva , Ahamad Shaik Khadeer , Shreya Arvini
Published: February 2023

Public health problems such as tuberculosis remain a major concern, especially in developing countries. According to WHO (World Health Organization), for every second someone gets infected with tuberculosis. India is the second most populated nation in the world contributes to 23% of TB incident cases annually out of 9.6 million worldwide. The overall morbidity and mortality associated with TB are reduced with early initiation of anti-TB treatment. In India, most antituberculosis regimens are Rifampicin-based under the Revised National Tuberculosis Control Program (RNTCP). Despite its rarity, deep venous thrombosis (DVT) should be considered especially in those with severe disseminated or pulmonary tuberculosis. This case report describes a 31-year-old female with pulmonary tuberculosis initiated on rifampicin-based antituberculosis treatment presented with deep vein thrombosis.

Keywords: Tuberculosis, Deep vein thrombosis, pulmonary tuberculosis
Effect of Hydromethanolic Extract of Stem Bark of Lannea kerstingii on Anemia and Hepcidin Production
Authors: Magnang Hèzouwè , Kueviakoé Messanh Délagnon Irénée , Togbenou Komlatsè , Agbonon Amegnona
Published: February 2023

Introduction: Stem bark of Lannea kerstingii is used in Togo for its anti-anemic effect. The aim of this study was to verify the efficacy of extracts of L. kerstingii’s bark in the treatment of anemia and to explore its mechanism of action. Materials and Method: L. kerstingii stem bark was collected in the city of Kpalimé, located at 120 km northwest of Lomé. Hydromethanolic extract was obtained by evaporation. Two protocols were carried out and 20 twelve-week-old rats that had an average weight of 175.17±16.8 grams were used. The first protocol consisted of inducing anemia in rats by intraperitoneal injection of phenylhydrazine, then force-feeding them with L. kerstingii extract and measuring the effect of this extract on their hemoglobin levels.  The second protocol investigated the effect of the extract on the serum hepcidin level, after oral administration of carbon tetrachloride to rats. Hepcidin levels were measured by the ELISA technique. Results: L. kerstingii stem bark extract significantly corrected the anemia induced by phenylhydrazine use: in fact, the anemia of rats that received L. kerstingii extracts was corrected. Control rats that received folic acid had a correction of their anemia too. But, rats that received only saline remained anemic. However, no correlation between the level of extract consumption and the level of hepcidin was established. Conclusion: L. kerstingii bark hydroethanolic extracts increase hemoglobin levels in anemic rats. The main challenge that needs to be solved is determining the minimum dose to be consumed to ensure its effectiveness.

Keywords: Lannea kerstingii, anemia, hepcidin, wistar rat.
Estimations of Serum Creatinine, Urea, and Some Urine Parameters among Patients with Type 2 Diabetes Mellitus after More than Ten Years Disease Onset
Authors: Ahmed Mohammed Abdelsalam , Elmukashfi Salman Taha Ahmed , Ahmed Najah Abdelwahab
Published: February 2023

Background: Assessment of a patient’s renal function may be used for two different purposes. One is to diagnose impaired renal function, and the other is to detect the presence of a progressive loss of renal function over time 1. In Sudan according to our knowledge there is lack of information regarding the impact of prolong type 2 diabetes mellitus on the renal function.

Objective: This study aims to assess renal function described as serum creatinine, urea and some urine parameters in type 2 diabetics after more than ten years onset. To detect impact of patient age and the duration on renal function.

Materials and methods: This study was designed as case control study, carried out in Northern State, Al Dabbah, during the period from Februarys to June 2014. Include 100 samples (57 males and 43 females), 50 samples collected from patient with more than ten years type 2 diabetic (27 males and 23 females) and 50 samples collected from healthy volunteers as pre described by physical examination and medical history (30 males and 20 females). 

Results: The results showed statistically significant increase in the serum levels of creatinine and urea in diabetic compared to their copartner with p.value 0.000 and mean ± SD (3.29±2.25, 1.28±0.35) mg/dl and (63.88±3.38, 21.28±5.48) mg/dl for diabetic and non-diabetic respectively. urine parameters showed elevation and presence of albumin 35% in diabetic and 1% in non-diabetic, sugar 99% for diabetic and 0% in non-diabetic, acetone 60% for diabetic and 0% for non-diabetic, pus 55% for diabetic and 5% for non-diabetic, calcium oxalate 66% for diabetic and 1% for non-diabetic, RBCs 5% for diabetic and 2% for non-diabetic, yeast cells 2% for diabetic and 1% for non-diabetic, epithelial cells 11% for diabetic and 1% for non-diabetic. 

Conclusion: There were significant increase in serum levels of creatinine and urea. And urine albumin, sugar, acetone, pus and calcium oxalate. Positive correlation between duration and urea and no correlation between duration and creatinine in case group. There were no significant changes in RBCs, yeast cells and epithelial cells. Patients should have regular screening renal function tests.
O/W Pickering emulsion stabilized by magnesium carbonate particles for drug delivery systems
Authors: Sy Papa Mady , Dieng Sidy Mouhamed , Djiboune Alphonse Rodrigue , Soumboundou Mamadou , Cisse Fatou Diop , Dieme Mouskeba Sire , Ndong Boucar , Diouf Louis Augustin Diaga , Mbaye Gora , Mbodj Mamadou , Diarra Mounibé
Published: February 2023

This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing particles composed of magnesium carbonate particles. Pickering oil-in-water emulsions stabilized with magnesium carbonate particles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of magnesium carbonate particles on the physicochemical properties of Pickering emulsions. The O/W Pickering emulsion was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by magnesium carbonate particles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and magnesium carbonate particles allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.

Keywords: emulsion -Pickering-magnesium carbonate- ibuprofen-oral bioavailability
Prophylactic aspects and therapeutic potential of Turbud (Operculina turpethum L) in Unani medicine: An evidence-based appraisal
Authors: Bashir Fouzia
Published: February 2023

Abstract

Turbud (Operculina turpethum L.) belongs to the family Convolvulaceae, a potent and well-known medicinal herb, used in Unani system of medicine to treat several diseases. It is a large perennial twinner with milky juice. Roots are long, slender, fleshy, and much branched. In classical text it is mentioned that the Turbud which is white in colour, light weighted and having resin on both ends is of good quality. In Unani system of medicine, its main actions are expectorant and laxative and used in several diseases like arthritis, ascites, gout, hemiplegia etc. According to Ibn Sina use of Turbud along with zanjabeel is more effective. It has been used as an important component in many compound formulations such as Itrifal Ustu-khud’dus, Itrifal Zamani, Itrifal Muqil, Itrifal Mulaiyyin. The major chemical constituents present are turpethin, glucoside, jalapine, convolvulin etc. Operculina turpethum L. is validated for its different pharmacological actions like anti-inflammatory effect, and ulcer protective etc. The present review comprehensively embodied its phytochemical, pharmacological and pharmacognostic description.
A Pilot study on thyroid status, lipid profile creatine kinase in human cardiac patients
Authors: Pancholi Boskey , Gautam Manish
Published: February 2023

Background: The progression of Coronary Heart Disease (CHD) is linked to a multitude of comorbidities, such as thyroid dysfunction, dyslipidemia. Objectives were to determine the thyroid and serum lipid profile, cholesterol, triglycerides and creatin kinase profile of CHD patients and to establish correlation between severity of cardiac disease with these two metabolic parameters.

Methods: This was a prospective study conducted among 55 CHD patients over 1 year admitted in the department of cardiology, General Government Hospital, Bikaner.

Results: There are 66% male and 36% female patients among the 55 study cases. Majority of the patients (54/55) exhibited higher T3 concentration, whereas one patient has low T4 value accompanied by 14 patients with high TSH value. Three patients have higher value of cholesterol with 17 patients of higher triglycerides levels. Among the patients eleven demonstrated higher creatine kinase values. 

Conclusions: The numbers of patients increasing with decreasing T3 and increasing thyroid stimulating hormone (TSH) proportionate to the severity of the cardiac failure. In addition, hypothyroidism is becoming more common in people with chronic cardiac disease. Serum triglycerides, LDL and HDL levels rise statistically significantly in CHD patients.

Keywords: Dyslipidemia, CHD, Cholesterol, triglycerides, TMB.
Transferosomes: A Novel Topical Approach
Authors: Kodi Shruti Rao , Reddy M. Sunitha
Published: February 2023

Transdermal drug delivery technologies have gained attention in recent years due to their advantages over conventional drug delivery systems. Transdermal drug delivery is limited because the stratum corneum functions as a barrier. Transferosomes are ultradeformable vesicles consisting of a lipid bilayer with phospholipids and an edge activator. After topical treatment, transferosomes can deliver larger quantities of active ingredients to deeper skin layers than liposomes. Generally, molecules with a molecular weight of more than 500 Daltons cannot penetrate through skin. As a result, this route can only be used to give a few medications. Therefore, this issue can be solved by encapsulating the medicine in a transferosome. Drugs that are hydrophilic, lipophilic or amphiphilic can be enclosed in transferosomes, which have a bilayer structure and a higher penetration efficiency than traditional liposomes. The most prevalent lipid found in a cell membrane, phosphatidylcholine, is found in high concentrations in the majority of transferosomes. Surfactants including sodium deoxycholate, Tween 80, and span 80 are frequently utilized as edge activators since they increase skin tolerance and reduce the chance of unfavorable effects. Due to their elastic nature, transferosomes can bend and squeeze themselves as a complete vesicle through tiny pores that are much smaller than their size.

Keywords: Transferosomes, Transdermal drug delivery, stratum corneum