bluuebunny/crossref_metadata_2025 huggingface dataset:
Bariatric surgery and obesity: the intersection of theory and practice
Authors: Kunitskaya N.A. , Poliakova V.V. , Tokareva T.P. , Chistiakova A.V.
Published: July 2024

Bariatric surgery is the main method of treating pathological conditions associated with obesity. However, at present, there is still a frequent recurrence of obesity, a large number of complications, and lifelong monitoring and correction of emerging metabolic disorders are required. The article analyzes the results of modern bariatric surgery and provides a clinical example.
Design Website for the Laboratory of Communication Science Department, University of Mataram
Authors: Ida Ayu Sutarini Ida Ayu Sutarini , Safitri Baiq Vira , Novita Maulida  , Putra Muhammad Firdaus Julianda
Published: July 2024

The website is an information technology system that makes transactions easier for us nowadays. Utilization of the website at the Multimedia Laboratory in the Communication Science Study Program at Mataram University to replace the manual system in the process of borrowing equipment, calculating equipment stock, and creating reports. Systems that are still manual often cause problems in data accuracy and transparency. So a website-based information system is needed to overcome this problem. The aim of this research is to design a User Interface and User Experience for the Multimedia Laboratory website at the Communication Science Study Program, University of Mataram. This research method uses the User Cantered Design (UCD) model which consists of four stages, namely: (1) specify the context of use; (2) specify user and organizational requirements; (3) produce design solution; and 4) evaluate design against user requirements. Based on interviews with five informants, they produced a solution for displaying the user interface of the Multimedia Laboratory website, Communication Science Study Program, Mataram University. The UI design was designed based on user concerns about renting tools and items manually. The solution offered is in the form of data availability for laboratory equipment, updated item data, and responsive customer service.
Communicating Climate Change Through Local Traditions of Bayan Village, North Lombok Regency
Authors: Miharja Dian Lestari , Baiq Vira Savitri  , Diyah Indiyati  , Eka Putri Paramita  , Aj Aditya , Ningrum Bq Aulia Anita
Published: July 2024

Disasters are events that are difficult for science to predict. There are many types of disasters that occur, especially in the Bayan area, North Lombok Regency. One of the disasters that occurs is a disaster due to climate change. Many parties are paying attention to this situation, giving rise to various forms of training and technical guidance related to disaster mitigation. Various forms of mitigation knowledge are accepted by the community. One of them is community knowledge and adaptation to disasters based on local knowledge which can be said to be part of the disaster communication process. If linked to local knowledge in disaster studies, this communication is characterized by symbolic language reflected in dances, games, rituals, etc. This communication symbol has been formulated from generation to generation based on prevailing traditions. So it is in this context that traditional traditions as local knowledge emerge as an alternative source of knowledge. It is possible for this knowledge to have an integrative nature and influence each other with global knowledge. Starting from this point, researchers feel it is important to know in depth how to communicate awareness of disaster mitigation related to climate change through local traditional traditions. This research uses a qualitative descriptive method through in-depth interviews and FGD strategies, and then the validity of the data is analyzed through data triangulation. So the results show that there are several efforts to communicate climate change to the indigenous people of Bayan village, namely: Preserving Traditions Related to Nature, Establishing Traditional Schools to Build Knowledge Related to Traditional Traditions, and Building Awareness Through Awig-Awig. There are inhibiting and supporting factors in efforts to preserve the environment through traditional rituals. Inhibiting factors are the limited distance between residents' houses and communicators, supporting factors are culture, family background, and norms.
Use of Gamification in Teaching Vocabulary of 11th Grade Students at SMAN 4 Mataram
Authors: Aisyah Baiq , Muhaimi Lalu , Arafiq
Published: July 2024

This study delves into the transformative potential of integrating gamification principles into vocabulary learning for 11th-grade students at SMAN 4 Mataram. Vocabulary acquisition is critical for academic progress, especially in preparation for standardized exams and college admissions, yet conventional methods often lack student engagement. Gamification, defined as the incorporation of game elements into non-gaming contexts, emerges as a promising strategy. The research explores how English teachers at SMAN 4 Mataram employ gamification, addressing questions about the types used, advantages gained, and obstacles faced. Using a qualitative descriptive approach, the study identifies two principal gamification classifications: content gamification, involving modifications to educational materials, and structural gamification, integrating game elements without altering content. Teachers utilize diverse gamification methodologies, fostering interactive learning environments. Challenges include accommodating diverse student abilities and aligning with evolving curriculum requirements. Theoretical implications span educational gamification, cognitive processes in vocabulary acquisition, and motivation theories. Practically, the study aims to enhance students' vocabulary skills, academic performance, and engagement, offering valuable insights for educators and policymakers in leveraging gamification for improved language learning outcomes.
KONSTRUKSI DAN KLONING GEN CelE PENYANDI ENZIM SELULASE SEBAGAI KANDIDAT ENZIM BAGI INDUSTRI PANGAN DAN AGROINDUSTRI
Authors: Sukarne Sukarne , Hasma Hasma , Jannah Raudatul , Suryadi Muhammad Aidil Fitriyan Fadjar , Unsunnidhal Lalu
Published: July 2024

Penelitian konstruksi dan kloning gen CelE, yang merupakan penyandi enzim selulase dari Ruminococcus plavefaciens, muncul sebagai respons terhadap kebutuhan mendesak akan sumber daya enzim yang efisien dalam industri pangan dan agroindustri. Enzim selulase, dengan fokus pada CelE, memiliki peran vital dalam proses degradasi selulosa, sebuah komponen utama dalam dinding sel tanaman. Keberadaan Ruminococcus plavefaciens sebagai sumber gen CelE menarik perhatian karena mikroorganisme ini terdapat dalam sistem pencernaan hewan ruminansia dan memiliki potensi besar untuk menghasilkan enzim selulase yang efisien. Tujuan dari penelitian ini adalah untuk membuat dan mengkloning plasmid pET15b dengan gen CelE. Konfirmasi gen CelE pada DNA rekombinan dilakukan dengan metode identifikasi resistensi bakteri host pada media dengan antibiotik dan koloni PCR. Penelitian ini dilaksanakan dengan menerapkan metode sebagai berikut: Pelaksanaan Optimasi Kodon dan Konstruksi Plasmid Rekombinan (CelE), Persiapan Sel Kompeten, Transformasi Sel, Uji PCR Koloni Transforman Hasil penelitian menunjukkan bahwa penelitian ini telah berhasil mendapatkan bakteri transforman yang diharapkan dengan hasil Uji PCR Koloni Transforman mendapatkan product size yang sesuai yaitu 205 bp, sehingga dapat disimpulkan plasmid pET15b dengan gen CelE yang telah dioptimasi berhasil dikonstruksi dan dikloning.
Pengaruh Lama Pengeringan Terhadap Sifat Kimia dan Fisik Daun Salam (Syzgium polyanthum)
Authors: Anggraini Ines Marisya Dwi , Mulachela Fathiyah , Zainuri Zainuri , Handito Dody
Published: July 2024

Salam (Syzygium polyanthum) merupakan tanaman rempah-rempah asal Indonesia yang bisa dimanfaatkan untuk berbagai tujuan medis maupun non medis. Daun Salam mengandung berbagai senyawa bioaktif. Salah satu cara untuk memperpanjang umur simpan daun Salam adalah dengan pengeringan. Proses pengeringan dapat merusak kandungan nutrisi produk pascapanen, terutama komponen bioaktif. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh lama pengeringan dengan metode oven pada sifat kimia dan fisik daun Salam. Pengeringan dilakukan menggunakan oven yang dilengkapi blower dengan suhu untuk semua perlakuan yaitu 50oC dan waktu pengeringan 50 menit, 70 menit, 90 menit, 110 menit, 130 menit, dan 150 menit. Parameter yang diamati dalam penelitian ini yaitu aktivitas antioksidan, kadar air, kadar abu, warna dan rendemen daun Salam kering. Data hasil pengamatan dianalisis keragaman (Analysis of Variance) dengan taraf nyata 5% dengan menggunakan software Costat. Jika terdapat perbedaan yang nyata antar perlakuan, maka diuji lanjut dengan uji Beda Kecenderungan atau Metode Ortogonal Polynomial (MOP) pada taraf 5%. Lama waktu pengeringan  memberikan pengaruh yang bebeda nyata terhadap aktivitas antioksidan, kadar air dan rendemen, namun tidak berbeda nyata terhadap kadar abu dan warna. Semakin lama waktu pengeringan akan menurunkan aktivitas antioksidan, kadar air dan rendemen daun Salam.
Optimasi Proses Ekstraksi Propolis dari Limbah Perasan Madu Trigona dengan Penggunaan Pelarut Air
Authors: Rahayu Tri Isti , Sinaga Yesica Marcelina Romauli , Perdhana Firman Fajar , Zuhdia Lulu Diani
Published: July 2024

Propolis merupakan zat resin alami yang dihasilkan oleh lebah dan memiliki berbagai manfaat kesehatan yang telah banyak diteliti. Ekstraksi propolis dari limbah perasan madu Trigona umumnya masih menggunakan pelarut organik. Propolis dapat diekstraksi menggunakan pelarut air dengan beberapa perlakuan tertentu Penelitian ini bertujuan untuk mendapatkan ekstraksi propolis yang optimal dengan menggunakan pelarut air yang diketahui aman dan murah. Optimasi proses ekstraksi air dipadukan dengan berbagai metode ekstraksi seperti maserasi dingin, maserasi panas (suhu 60°C), Ultrasound-Assisted Extraction (UAE), dan Microwave-Assisted Extraction (MAE), dibandingkan dengan kontrol pelarut organik dan propolis komersial. Parameter yang diamati dari ekstrak yang diperoleh adalah pH, skrining fitokimia (alkaloid, fenolik, saponin, steroid, dan flavonoid), warna, aktivitas antioksidan, dan aktivitas antibakteri. Data dianalisis menggunakan analisis varians dengan taraf signifikansi 5%. Hasil pengujian menunjukkan bahwa ekstraksi air dengan MAE menghasilkan ekstrak propolis dengan kandungan antioksidan tertinggi dan mampu menghambat pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus.
The Effect of Mocaf And Seaweed Pulp (E. cottonii) Ratio on The Characteristics of Brownies Chips
Authors: Soewondo Galuh Ayuningtyas , Basuki Eko , Cicilia Siska
Published: July 2024

Brownie chips are one of the brownie innovations with a crunchy texture and are made from wheat flour. An alternative substitute for wheat in making brownies is mocaf and seaweed pulp is added to improve its characteristics. This study aimed to determine the effect of the ratio of mocaf and seaweed pulp (E. cottonii) on the nutritional value, physical, and organoleptic properties of brownie chips. This study used a completely randomized design (CRD) with 5 treatments, namely ratio of mocaf and seaweed pulp (E. cottonii) P1 (100%:0%), P2 (90%:10%), P3 (80%:20%), P4 (70%:30%), P5 (50%:50%). Parameters observed were moisture content, crude fiber content, protein content, baking powder and organoleptic (aroma, taste, texture and color). Observations were analyzed using analysis of variance (Analysis of Variance) at the level of 5% using the application Co-State. Further test was carried out using the Least Significant Difference (LSD) for significant difference data. The results showed that the ratio of mocaf and seaweed pulp (E. cottonii) gave significantly different effect on moisture content, crude fiber, protein, breaking power and organoleptic tests (hedonics and scoring) texture and taste, but not significantly different on organoleptic tests (hedonics and scoring) aroma and color.The best treatment was obtained in P3 treatment (80%: 20%) with 4,03% moisture content, 3,37% crude fiber content, 4,92% protein content, 3,75N fracture power; and all organoleptic parameters including aroma, taste, texture and color were accepted by the panelists based on the hedonic test with a like level of preference.
How to Make Future Cities Smart in the Realm of Environmentally Friendly Healthy Cities? Looking from the Perspective of Ease of Living Index
Authors: Gupta Sakshi , Neeraja Lugani Sethi
Published: July 2024

Rapid urbanization and environmental issues have led the Government of India to implement urban development initiatives like Heritage City Development and Augmentation Yojana, Atal Mission for Rejuvenation and Urban Transformation, Smart Cities Mission, Deen Dayal Antyodaya Yojana-National Urban Livelihood Mission, and Swachh Bharat Mission-Urban to improve citizens' quality of life. The Ease of Living Index (EOL), developed to assess the outcomes of these initiatives, is a data-driven assessment tool aligned with the Sustainable Development Goals that enables cities to adopt evidence-based planning and execution. It assesses the well-being of citizens in 111 cities, including cities under the Smart Cities Mission, capital cities, and cities with populations over one million. The concept of healthy cities gained popularity in the South-east Asian Region of the World Health Organization, with the Healthy City Network Assessment Tool being introduced in 2021 to help cities assess their health profile in its eleven member countries, including India. In view of NITI Aayog's 2021 recommendation for the development of 500 healthy cities by 2030, there is a need to expand the scope of the existing EOL Index (2020). This research aims to integrate the healthy city evaluation criteria from WHO's South-east Asia Regional Guidelines with the EOL Index 2020 to develop an integrated tool for data-driven assessment of India's proposed healthy cities program. The study based on literature review and comparative analysis identifies 8 determinants, 28 sub-determinants and 112 indicators, enhancing the comprehensiveness of the EOL Index to promote smart, environmentally friendly, healthy, and sustainable urban development.
The analysis of the role of Indonesia naval base to support national logistic supplies with a dynamic system approach (A Conceptual Review)
Authors: Mukhlis  , Yoyok Nurkarya Santosa  , Adi Bandono  , Okol Sri Suharyo
Published: July 2024

The strategic position of Indonesia, an archipelagic country, necessitates efficient and reliable naval logistics to support national security and economic stability. This paper analyzes the role of Indonesia's naval bases in supporting national logistic supplies using a dynamic system approach. By integrating various factors affecting naval logistics, this study provides insights into optimizing logistics operations and ensuring the effectiveness of naval bases in supporting national supply chains. The objectives of this study are to Identify the key factors influencing the efficiency of naval logistics. Develop a dynamic system model to analyze these factors. Propose strategies for optimizing logistics operations through naval bases. This study offers a comprehensive approach to understanding and improving the logistics support provided by naval bases. The findings will help policymakers and military planners enhance logistics operations and ensure a reliable supply chain. This study presents a system dynamics approach to analyzing the role of Indonesia's naval bases in supporting national logistic supplies. The model provides a comprehensive framework for understanding and optimizing naval logistics operations.
Policy approaches for bioenergy development in response to climate change: A conceptual analysis
Authors: Jephta Mensah Kwakye  , Darlington Eze Ekechukwu  , Olorunshogo Benjamin Ogundipe
Published: July 2024

This review paper explores policy approaches for integrating bioenergy into agricultural practices to address climate change. It examines existing national and international policy frameworks, analyzes the potential synergies between bioenergy and agriculture, and identifies challenges and opportunities for bioenergy development. A conceptual model for policymakers is proposed, emphasizing policy instruments, stakeholder engagement, and monitoring frameworks to optimize bioenergy outcomes. The model underscores the importance of holistic approaches tailored to specific contexts. By prioritizing sustainability, equity, and inclusivity, policymakers can unlock the transformative potential of bioenergy to mitigate greenhouse gas emissions, enhance climate resilience, and promote sustainable development.
Prediction of post-covid-19 using supervised machine learning techniques
Authors: Sunday Akinwamide  , Rashidat Idris-Tajudeen  , Titilope Helen Akin-Olayemi
Published: July 2024

The COVID-19 pandemic has had a profound impact on global health, necessitating the development of predictive models to manage and mitigate its effects. Early diagnosis is crucial for preventing the progression of diseases that can significantly endanger human life. This study explores the application of supervised machine learning techniques to predict Post-COVID-19 outcomes, including long-term health complications and recovery trajectories. In this study, we utilized 10 advanced supervised machine learning algorithms, including both stand-alone models (Decision Tree, Random Forest, Logistic Regression, K-Nearest Neighbors, Support Vector Machine, and Gaussian Naive Bayes) and ensemble learning techniques (Bagging Decision Tree Ensemble, Boosting Decision Tree Ensemble, Voting Ensemble, and Stacked Generalization – Stacking Ensemble). These models were applied to analyze and predict the presence of COVID-19 using the COVID-19 Symptoms and Presence dataset from Kaggle. The performance of each model was evaluated using an 80:20 train-test split as well as 5, 10, 15, 20, and 25-fold cross-validation. Evaluation metrics included accuracy, precision, recall, F1-score, and the confusion matrix. The results indicate that the Decision Tree algorithm outperformed the other models, achieving an accuracy of 98.81%, a precision of 1.00, a recall of 0.98, and an F1-score of 0.99. Our results indicate that machine learning models can effectively predict Post-COVID-19 conditions, providing valuable insights for healthcare providers and policymakers.
PENGARUH MODEL PEMBELAJARAN PEER LED TEAM LEARNING (PLTL) BERBANTUAN SOAL HOTS DALAM MENINGKATKAN LITERASI NUMERASI MATEMATIKA SISWA KELAS X SMA NEGERI 1 DOBO
Authors: Nurwijaya Sugian , Purba Pratiwi Bernadetta
Published: July 2024

Kurikulum di Indonesia saat ini adalah kurikulum Merdeka Belajar dan yang menjadi salah satu fokusnya yakni keterampilan literasi numerasi. Oleh karena itu, tujuan dari penelitian ini yaitu untuk mengetahui pengaruh model pembelajaran Peer Led team Learning (PLTL) berbantuan soal HOTS dalam meningkatkan literasi numerasi siswa kelas X SMA Negeri 1 Dobo. Adapun Metode penelitian yang digunakan yaitu eksperimen dengan desain pre-eksperimen. Penelitian ini dilakukan di SMA Negeri 1 Dobo di Kabupaten Kepulauan Aru. Penelitian ini melibatkan semua siswa kelas X, dengan rincian kelas: X1, X2, dan X3, totalnya 75 siswa. Selanjutnya hasil penelitian berdasarkan hasil uji-t berpasangan diketahui nilai Sig. (2-tailed) 0,000 di mana kurang dari taraf signifikan 5% (0,000 < 0,05) sehingga H0 ditolak yang artinya ada perbedaan rata-rata kemampuan literasi numerasi peserta didik dalam menyelesaikan soal HOTS sebelum dan setelah diberikan perlakuan. Berdasarkan analisis penelitian maka dapat disimpulkan penerapan model pembelajaran Peer Led Team Learning (PLTL) berbantuan soal HOTS memberikan pengaruh terhadap kemampuan literasi numerasi peserta didik X SMA Negeri 1 Dobo
PERBANDINGAN SELF-EFFICACY MATEMATIS ANTARA SISWA YANG BERMINAT TINGGI DAN RENDAH DALAM PEMBELAJARAN MATEMATIKA DI SEKOLAH MENENGAH ATAS
Authors: Nur Al Fariana  , Nur Hardiani  , Habibi Ratu Perwira Negara  , Habib Ratu Perwira Negara  , Kiki Riska Ayu Kurniawati  , Syaharuddin
Published: July 2024

Penelitian ini menggunakan metode kuantitatif dengan melibatkan 53 responden dari berbagai jenis Sekolah Menengah Atas (SMA/MA/SMK), dengan 9 siswa laki-laki dan 44 siswa perempuan. Instrumen utama yang digunakan adalah angket yang difokuskan pada dua variabel utama, yakni self-efficacy matematis dan minat belajar matematika. Penelitian bertujuan untuk mengumpulkan data yang representatif dan relevan mengenai self-efficacy matematis dan minat belajar matematika di tingkat SMA. Setelah proses pengumpulan data, dilakukan analisis menggunakan regresi linier berganda untuk mengidentifikasi korelasi antara self-efficacy matematis dan minat belajar siswa. Hasil penelitian menunjukkan adanya perbedaan yang signifikan dalam self-efficacy matematis antara siswa dengan minat belajar matematika tinggi dan rendah. Implikasi penelitian ini menyoroti pentingnya mempertimbangkan faktor-faktor seperti pengalaman awal, dukungan orang tua, dan strategi pembelajaran dalam merancang strategi efektif untuk meningkatkan self-efficacy dan hasil belajar siswa dalam mata pelajaran matematika di SMA. Dengan demikian, penelitian ini diharapkan memberikan kontribusi dalam pemahaman dan perbaikan proses pembelajaran matematika di tingkat SMA.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF PADA MATERI BUNGA TUNGGAL MAJEMUK DAN ANUITAS SISWA KELAS XI KULINER SMK NEGERI 6 PADANG
Authors: Marten Delvi , Delyana Hafizah , Edriati Sofia
Published: July 2024

Permasalahan  belajar yang terjadi pada siswa salah satunya yaitu  kurangnya daya tarik siswa dalam belajar, pemahaman terhadap materi rendah dan nilai ulangan harian yang masih tergolong rendah  dikarenakan siswa kurang memahami materi pembelajaran dan siswa kurang tertarik untuk belajar dengan proses pembelajaraqn yang masih bersifat konvensnal. Bahan ajar yang disajikan secara konvensional akan membuat siswa cenderung malas untuk belajar karena tidak dapat menarik perhatian siswa dalam belajar. Penelitian ini dilaksanakan di SMK Negeri 6 Paang Jenis penelitian ini adalah penelitian pengembangan dengan model pengembangan ADDIE. Tahapan pada model pengembangan ini terdiri atas lima tahapan, yaitu analisis (analyze), perancangan (design), pengembangan (development), implementasi (implementation), dan evaluasi (evaluation). Berdasarkan hasil analisis data diperoleh bahwa media pembelajran interaktif yang dikembangkan memperoleh hasil validitas materi dan media sebesar 82,95% dan 88% dengan kategori sangat tinggi . Hasil nilai akhir  nilai praktikalitas guru  sebesar 87.83% dengan kategori sangat praktis dan nilai praktikalisasi siswa sebesar 83.43% dengan kategori sangat praktis. Berdasarkan hasil penelitian dapat disimpulkan bahwa media pembelajaran interaktif pada materi bunga tunggal, majemuk dan anuitas di SMK Negeri 6 Padang dinyatakan valid dan praktis untuk di gunakan pendidik dan peserta didik dalam kegiatan pembelajaran.
DESKRIPSI KEMAMPUAN REPRESENTASI MATEMATIS SISWA KELAS VIII SMP/MTS DITINJAU DARI GAYA KOGNITIF VISUALIZER
Authors: RIO RIO FABRIKA PASANDARAN
Published: July 2024

Kemampuan representasi matematis merupakan salah satu kemampuan dasar yang harus dimiliki oleh tiap siswa dalam menelaah, mengungkapkan, dan menggali sebuah ide-ide matematika baik berupa permasalahan, informasi, definisi, dan lain-lain untuk menemukan sebuah solusi yang tepat sesuai hasil representasinya, baik berupa gambar, kata-kata, tabel, simbol, grafik, maupun pola dalam matematika. Alasan terbesar yang menjadi penghambat ide-ide cemerlang siswa muncul yakni lemahnya kemampuan representasi matematis siswa sehingga menghambat siswa dalam menentukan penyelesaian permasalahan matematika bahkan kurang cermat dalam membaca soal cerita, lemah dalam analisis masalah, kurang teliti, dan kesulitan menghubungkan antar konsep. Subjek penelitian ini adalah siswa kelas VIII di salah satu MTs yang berada di kecamatan Angkona yang berjumlah dua siswa. Instrumen yang digunakan untuk penelitian ini adalah Visualizer Verbalizer Questionnaire (VVQ). Soal tes kemampuan represesentasi matematis dan wawancara. Penelitian ini menggunakan metode deskriptif kualitatif. Berdasarkan analisis data, dapat disimpulkan bahwa kemampuan representasi siswa dengan gaya visualizer dan verbalizer cukup baik ada beberapa hal yang menarik dari kedua subjek penelitian tersebut yakni subjek Visualizer (SVi) dalam menyeleseikan sebuah permasalahan mengedepankan aspek visual dalam menelaah tiap pertanyaan dan informasi yang dituangkan ke dalam bentuk lebih sederhana dalam merepresentasikan sebuah gambar dan ilustrasi bangun datar.
Kata Kunci: Kemampuan Represesntasi Matematis; Visualizer
Rare forms of thyrotoxicosis: thyrotropin-secreting pituitary adenomas
Authors: Telegina M. A. , Belaya Zh. E.
Published: July 2024

Thyrotoxicosis most often occurs due to autoimmune diseases of the thyroid gland or a multi-nodular toxic goiter, but it can also be caused by TSH-secreting pituitary adenomas. In the presence of these adenomas, the levels of circulating free T3 and T4 increase in the absence of suppression, even with elevated TSH levels. Incorrect interpretation of results from studies that only measure TSH can lead to erroneous diagnoses and management strategies for patients, including unnecessary surgery or radioactive iodine therapy. This can contribute to the growth of pituitary tumors. Various tests have been used to try to diagnose them, but none have proven to be eff ective. Only laboratory tests in combination with MRI of the pituitary can accurately diagnose and prescribe treatment. When choosing a treatment for TSH-producing pituitary adenomas, preference is given to the surgical method of transsphenoidal adenomectomy. If surgery is not possible or eff ective, the method used to normalize TSH levels is to prescribe somatostatin analogs. In some cases, it is possible to use somatostatin analog therapy before neurosurgery. In exceptional circumstances, radiation therapy may be used, as with other types of adenomas.
Gut microbiome: new diagnostic and treatment options
Authors: Mayev I. V. , Lyamina S. V.
Published: July 2024

The gut microbiome is of undeniable contribution to the functioning of numerous human organ systems, including higher nervous activity and behavioral reactions, and largely determines the activity of the immune system. To date, a large amount of knowledge has been accumulated about the importance of the composition, diversity and functional properties of the gut microbiota both for maintaining the human body in a state of health and for the development of pathology. Changes in the human organism are inevitably accompanied by changes in species composition and microbiome diversity. Certain patterns of changes in the human gut microbiome throughout life, as well as changes in its functional activity under the infl uence of external factors and food preferences. This research is based on search results in databases and electronic libraries PubMed (MEDLINE), Embase, Cochrane Library, Google Scholar, eLibrary in the period from 2012 to 2023. The review is devoted to the analysis of gut microbiome as a marker and predictor of chronic socially signifi cant non-communicable diseases, as well as an integral component of health gain in the context of a personalized approach of modern therapeutic strategies.
Hemorrhagic complications of emergency endovascular interventions
Authors: Sukovatykh B. S. , Bolomatov N. V. , Sidorov D. V. , Sukovatykh M. B.
Published: July 2024

The article provides a systematic review of data from domestic and international literature on the issue of hemorrhagic complications that can occur during emergency endovascular interventions. It provides a generalized classifi cation of these complications and highlights the frequency of major and minor hemorrhages in diff erent locations, depending on their underlying cause. Various factors, causes, and mechanisms related to the development of hemorrhaging are discussed, including those associated with surgical access, vessel dissection, rupture, anticoagulation, anti-platelet therapy, and thrombolysis. Methods for preventing and treating these complications following endovascular procedures are also described in detail.
A decrease in the concentration of free blood glutathione in the acute phase of coronavirus infection
Authors: Kolevatova L. A. , Ovchinnikov Yu. V. , Gulyaev N. I. , Prokhorchik A. A. , Euro L. L.
Published: July 2024

Aim of the study: to investigate the dynamics of glutathione metabolite concentrations in the blood of patients during the acute phase of coronavirus infection, as well as their dependencies on each other, on NAD⁺ metabolites, the severity of the infl ammatory response, and pre-existing conditions. Materials and methods. Changes in the concentration of oxidized and reduced forms of glutathione and their ratio, as well as clinical and biochemical parameters, including NAD⁺ and NADPH⁺ metabolites, were analyzed in patients with new coronavirus infection COVID-19 during the acute phase. Results. A signifi cant decrease in the concentration of both reduced and oxidized forms of glutathione and an increase in the ratio of reduced to oxidized forms compared to the control were demonstrated. A positive correlation was noted between the severity of respiratory failure and the oxidized form of glutathione and NADPH⁺. The reduced form of glutathione had a positive correlation with the concentration of NAD⁺ and NADPH⁺ and a negative correlation with the presence of obesity and ferritin concentration. Conclusion. For the fi rst time, a decrease in the concentration of key components of the cell’s antioxidant defense system — glutathione system — has been shown in patients with COVID-19, opening up prospects for the development of treatment methods for patients in the active phase using sulfhydryl group donors.
Tuberous sclerosis. Clinical observation of a 10-year-old girl
Authors: Shiralieva R. K. , Asadova U. A.
Published: July 2024

Aim. Informing readers about the achievements of genetics, molecular biology, as well as the development of non-genetic diagnostic criteria for tuberous sclerosis, which reliably allow for a correct and timely diagnosis. Materials and methods. A retrospective analysis of our own 10-year observation of a girl suff ering from tuberous sclerosis is presented. Anamnestic data, conclusions of laboratory and neuroimaging methods of research, diagnostic criteria from 2012 (TSC Clinical Consensus Conference) were used to confi rm the diagnosis. Results and discussion. The clinical observation conducted represents a case of tuberous sclerosis, a rare genetically determined disease from the group of phacomatoses, observed for 10 years. The diagnosis was facilitated by the presence of speech and psychomotor development delay, pyramidal symptoms, and frequent seizures. The detected mutation in the gene (TSC1 or TSC2) with an autosomal dominant inheritance phenotype without fl uctuations would confi rm the established diagnosis, however, the patient’s mother refused examination. It was necessary to resort to another, no less reliable option to confi rm this diagnosis: the recommendations of the TSC Clinical Consensus Conference 2012 and based on the identifi ed primary (facial angiofi bromas, hypopigmented spots, cortical nodes, brain tubers, subependymal nodes) and secondary (numerous enamel pits in teeth, multiple kidney cysts) clinical signs present in our patient to establish the diagnosis. Conclusions. The presented clinical observation indicates the possibility of diagnosing tuberous sclerosis without genetic testing.
Implementasi Kebijakan Peraturan Bupati Gunungkidul No. 33 Tahun 2022 tentang Pengarusutamaan Gender dalam Pembangunan Daerah
Authors: Hapu Ndamayilu Wilfridus , Koja Marlince Tara , Lani Daghu Daniel , Mangutu Ndamu Namu Antonius
Published: July 2024

The Indonesian government affirms its commitment to gender equality, providing equal opportunities for women and men in national development, with the main aim of protecting the Indonesian nation and improving general welfare. Gunungkidul Regency, DIY, is facing serious cases of violence, especially sexual violence against minors. The government not only formulates policies, but also takes concrete steps in responding to these cases. Yogyakarta has a high risk of sexual violence, and regional regulations are an instrument for implementing gender equality in the public and private sectors. In the context of public policy, stakeholder involvement is considered important. Stakeholder analysis aims to identify the parties involved in implementing Gunungkidul Regent Regulation Number 33 of 2022. Qualitative research using the Institutional Analysis and Development (IAD) method concludes that the roles of stakeholders can be grouped into four categories. DPRD as contestants, Regional Government, Bappeda, and Police as players, society as subjects with high interests but limited power, and NGOs as supporting groups through campaigns. Stakeholder synergy is considered key to the success of policies to overcome gender gaps in Gunungkidul, ensuring the active participation of all parties to achieve the goals of gender equality and combat violence.
Mapmaking and Cartography as Philosophical Matters. An Introduction
Authors: Ragazzi Francesco
Published: July 2024

This issue of the Journal for the Philosophy of Language, Mind and the Arts perhaps stems from what might be an excess of ­presentism. It originates, that is, from the consideration of several unrelated events or processes, all of which occurred after the beginning of this century, that have to do with a renewed relevance of cartography and its expressive forms.
Ryle’s Conceptual Cartography
A Brief Introduction
Authors: Tanney Julia
Published: July 2024

Conceptual Cartography is a style of philosophical investigation, named and championed by Gilbert Ryle and somewhat akin to, but independent from, Wittgenstein’s examination of ‘language games’ in Philosophical Investigations. This study examines the impetus for this method which includes difficulties with the traditional approaches to conceptual analysis initiated by Plato’s Socrates and encouraged by later work in formal logic.
The ethno-mythological motif as a resource in the modern visual art of Siberia
Authors: Gerasimenko Darina Evgenevna
Published: July 2024

The article explores how the mythological beliefs of the indigenous peoples of Siberia have influenced the creation of artistic images in the work of contemporary Siberian artists. The goal of this study is to understand the role and presence of ethno-mythological motifs in the art of Siberia in the 21st century. The article briefly outlines the main stages of how these motifs have developed in Siberian art. It also examines the images that artists commonly use and classifies them. The scientific novelty of this research lies in introducing the names of new artists into scholarly discourse. As a result, it has been discovered that the imagery in many works is rooted in universal symbolism, which is characteristic of various world cultures. A significant portion of these images includes depictions of spirits who are the guardians of the land, animals, and anthropomorphic figures found on Neolithic artworks from the region, as well as in shamanic symbols, ethnic, mythological representations of the Siberian peoples, and folklore texts. In essence, traditional culture serves as a framework that gives shape to the semantic content of these artistic creations.
Development and implementation of video tutorials as a means of optimizing the independent work of students of a non-linguistic university in English
Authors: Zakharova Olga Olegovna
Published: July 2024

The purpose of the article is to substantiate the possibilities of developing and using video tutorials in the process of organizing independent work of generation Z students in a non–linguistic university in the discipline "Foreign language". The article clarifies the concept of "independent work of a student" within the framework of his foreign language training at a university, defines the features of its organization in the digital educational space. The novelty of the article lies in clarifying the methodological and technical features of creating educational video materials, on the basis of which a series of video tutorials has been developed and tested in the process of organizing independent work of students in the discipline "Foreign language". As a result of an experiment conducted with first-year students of the Trekhgorny Institute of Technology studying in the specialty "Application and operation of automated special purpose systems", the effectiveness of using video tutorials as a modern way of developing students' independent work skills during their foreign language training was confirmed.
Features of the use of chatbots in teaching foreign languages to students of a non-linguistic university (using the example of English)
Authors: Didenko Elvira Nikolaevna , Egorova Maia Aleksandrovna , Lagutkina Margarita Dmitrievna
Published: July 2024

The purpose of the study is to determine the possibilities of using chatbots when teaching foreign languages to students of a non–linguistic university using the example of English. The article examines the features of the use of information and communication technologies on the example of chatbots in the formation of communicative competence in English among students studying English as a foreign language in a non-linguistic university. The scientific novelty of the study is that it proves that chatbots can be customized to the individual needs of each student, which provides a personalized approach to learning and helps students achieve better results. As a result of the study, it was found that chatbots communicate with users in a "live" language, they play an important role in the methodology of teaching a foreign language and create a quasi-conversation. The architecture of chatbots combines a language model and computational algorithms to simulate informal communication. Using the example of two chatbots, algorithms for using artificial intelligence are shown in terms of their methodological potential.
Rhythmic and sound organization as the principle of structural integrity of I. Gogolev's poem "The Glade of Poetry"
Authors: Efremova Ekaterina Mikhailovna
Published: July 2024

The results are revealed based on the analysis of the poem by the national poet of Yakutia I. M. Gogolev "The Glade of Poetry" (1979), which played a significant role in the formation of an individual author's style. The choice of material is dictated by the desire for a more in-depth study of the poetics of poems, as well as insufficient knowledge of the author's poetry. The article deals with the problem of poetic integrity of the text from the point of view of rhythmic and sound organization. The purpose of the study is to identify some features of rhythmic and sound organization as the fundamental principles of verse structuring. Scientific novelty is determined by the possibility of establishing the specifics of I. Gogolev's individual style in the aspect of the problem of the integrity of the poetic text. As a result of the study, it was found that rhythmic composition is one of the basic principles of verse structuring. I. Gogolev consciously adheres to the model of symmetrical structure, which, according to our assumptions, is associated with the narrative course of the presentation of the system of thoughts.
Translation transformations in Russian translation studies: A theoretical and analytical review from the middle of the 20th century to the beginning of the 21st century
Authors: Lekomtseva Irina Alekseevna , Kuraleva Tatiana Vladimirovna
Published: July 2024

The purpose of the study is to present a theoretical and analytical review of works on the topic of translation transformations in Russian translation studies within the framework of a scientific discussion. The article discusses various approaches to the definition of translation transformations in Russian translation studies: linguistic approach, logical-formal approach; functional-communicative approach; information approach; semiotic approach. The material of this article demonstrates different, contradictory views on the development of scientific ideas about translation transformations, and also indicates the difficulty of defining a single metalanguage of translation theory in general and translation transformations in particular. The scientific novelty of the work consists in a comprehensive diachronic presentation of various approaches to the study of the problems of translation transformations in Russian translation studies from the middle of the 20th century to the beginning of the 21st century. According to the results of the review, it can be concluded that there is still no consensus in Russian translation studies on the essence of the concept of translation transformations. There is also no single typology of translation transformations. If earlier works are of a fundamental theoretical nature, then the works of recent years are distinguished by a more practice-oriented, applied orientation.
Comparative specificity of the original and translations of W. E. Henley's poem “Invictus”
Authors: Bolshakova Iustina Denisovna , Vlavatskaya Marina Vitalyevna
Published: July 2024

The purpose of the study is to identify the similarities and differences between the original and translations of W. E. Henley's poem “Invictus” from English into Russian in graphic, discursive, phonetic and linguistic forms, including semantic equivalence and poetic communication with the reader. The scientific novelty lies in the identification of the comparative specificity of the original and two translations of the above-mentioned work, performed by D. Magula and M. Shengaut. As a result of the study, it was found that in graphic, discursive and phonetic forms, the original and the translations, despite some differences, largely coincide. There are significant differences in the linguistic form at the morphological level, for example, in the usage of parts of speech. Word formation is almost identical in nature in all poems. The syntax of the translated versions is somewhat similar to that of the original text. At the lexical level, both similarities and differences were found in the vocabulary used. These words mostly correspond to the original text in terms of meaning. Generally speaking, the idea of the lyrical hero's strength is preserved in both translations. The emotional message is almost the same as in the original, which suggests that all authors have successfully communicated their poetry to the reader.
Teaching the means of professional communication (subject area – history of literature) to foreign philology students
Authors: Markov Vladimir Timofeevich , Markova Valentina Alekseevna
Published: July 2024

The purpose of the study is to create a technology for teaching foreign philology students to perceive and use the means of professional communication characteristic of the history of literature. The article characterizes the features of the text on the history of literature. Its typical content aspects are established, typical lexical and grammatical structures are identified – the means expressing these aspects. A system of exercises has been developed to teach the perception and use of text structures in the history of literature. The novelty of the undertaken research is determined by the fact that for the first time it provides a systematic linguodidactic description of a text on the history of literature. The identified specifics are linked to the nature of the exercises. As a result of the study, a technology for teaching means of professional communication in the field of literary history was compiled. Dominant (presented for active use) and non-dominant (intended for reception) structures expressing the main semantic aspects of a text in the history of literature were identified, a system of exercises was developed that teaches means of professional communication in the field history of literature.
Treatment of Localized Infections in Hard-to-Heal Wounds: An Integrative Review
Authors: Oliveira Letícia Maria de , Castro Larissa Carvalho de , Lucena Olga Luísa , Cortez Daniel Nogueira , Dantas Sônia Regina Perez Evangelista , Moraes Juliano Teixeira
Published: July 2024

Objective: To identify the knowledge production on the treatment of localized infections in hard-to-heal wounds. Method: An integrative literature review was conducted in the Virtual Health Library, Nursing Database, Scientific Electronic Library Online, Web of Science, Cochrane Library, Catalog of Theses and Dissertations of the Coordination for the Improvement of Higher Education Personnel, and PubMed. The selected articles had no time limit. The studies were exported to the Rayyan application and subjected to double-blind evaluation through title and abstract reading, based on inclusion and exclusion criteria. The information was analyzed and synthesized according to the level of evidence. Results: A total of 19 publications were fully analyzed. The evidence obtained on the topic includes wound hygiene, cleaning with 1% acetic acid, identification and treatment of biofilms, the use of dressings, and solutions with antimicrobial action. Conclusion: Localized wound infections have been the subject of various research studies, and the recommended practices refer to topical treatments.
A Narrative exploration of life transitions experienced by seasoned travelers during travel immersion
Authors: Lee Eunjoo , Du Kyunghee , Lee Yoon Jung ,   Korean Association for Qualitative Inquiry
Published: July 2024

This study aimed to deeply understand the influence of travel experiences on individuals’ identity and life. To achieve this, a purposive sampling method was employed to select three experienced travelers who had taken an average of three or more trips annually from 2015 to 2019, prior to the COVID-19 pandemic. Following Clandinin & Connelly’s (2000) narrative inquiry method, participants were invited to narrate their experiences, reflecting on the changes in their lives and psyche due to travel. The findings revealed that through travel, participants examined themselves, others, and the balance between work and life, thereby enhancing their social understanding. They developed an open-minded and proactive attitude towards life. Travel also acted as a significant resource for strengthening agency and expanding life experiences. Moreover, through these processes, participants underwent transitions in their work and attitudes, indicating that travel extends beyond mere relaxation to profoundly impact personal development and social interaction. Furthermore, the accumulated changes in identity and psyche resulting from travel suggest a potential for shifts in values and life trajectories. This study provides academic insights into understanding the impact of travel on individuals’ social interaction and development. It offers new perspectives in fields related to human psychology, including tourism studies. Additionally, it lays a foundation for developing meaningful approaches to planning and executing travel, thereby aiding in the development of travel-related policies and educational programs.