bluuebunny/crossref_metadata_2025 huggingface dataset:
Flaying the sheep: the 1657 assessment tax and the problems of government in Cromwellian Ireland
Authors: Little Patrick
Published: May 2023

The assessment tax on land, which paid the occupying army, increased steadily during the 1650s, and soon out-stripped the capacity of the Irish economy, slowly recovering from over a decade of war. Matters came to a head in 1657, when there were efforts by Irish M.P.s at Westminster to reduce the rate, and also pressure from Protestant landowners on the Dublin government to change the way in which the tax was administered. These initiatives brought together landowners from very different backgrounds and from all four provinces, in a coordinated campaign of lobbying which achieved considerable gains in Dublin but was less successful in London. This article uses new evidence to explore the problems endemic within the assessment system, the way in which influence could be brought to bear, and the difficulties encountered by those trying to change policies imposed from across the Irish Sea.
‘Many attend chiefly in search of pleasure’: the Great National Horse Show at the Royal Dublin Society, 1868–80
Authors: Murphy Sherra
Published: May 2023

This paper explores the foundation of the Dublin Horse Show from 1868–80, when it was held at the Royal Dublin Society's (R.D.S.) headquarters on Merrion Square. Early iterations were intended to address the depletion of the equine population in the mid-nineteenth century, a matter of concern for agriculture and industry, but also for those with an interest in sport and horses as opportunities for leisure. Horse shows arose nearly simultaneously in Ireland and England as intersections between associational culture, agricultural improvement and a burgeoning middle-class leisure sphere established animal shows as instruments for improving breeding, but also as forms of entertainment. The popular success of horse shows fostered the development of economic clusters, as local businesses began to depend on them as reliable sources of annual income. They also reflected equestrian sport's migration from largely elite pursuits into popular recreation, including competitions that would eventually lead to the modern sport of showjumping. The events established at the early R.D.S. Horse Show are still recognisable today in their combination of improvement and leisure based in the promotion of Irish horses as exemplars of sporting excellence.
Revolution and nationalism in Treatyite political thought, 1891–1924
Authors: Donnelly Seán
Published: May 2023

The last fifty years have witnessed the production of a large body of scholarship exploring the political and social history of the Irish Civil War and its aftermath. Debate has focused principally on the administrative abilities and democratic credentials of the Free State government and the extent to which revolutionary ideals were expressed institutionally following the ratification of the Anglo-Irish Treaty in 1921. However, there has been strikingly little attempt to contextualise, rather than appraise, the lineage of the moral and ideological assumptions embedded in the executive council's public professions of political conviction, or to understand Treatyite policy-making on its own terms. In particular, historians have tended to weigh and measure the performance of the Cumann na nGaedheal government against anachronistic and moralising definitions of what the Irish revolution stood for at the expense of any systematic attempt to reconstruct the manner in which relevant historical actors understood this relationship. Focusing on the heterodox intellectual firmament of the Irish-Ireland movement, this paper demonstrates that the Cumann na nGaedheal government never abandoned the political languages of the revolution; rather, they constructed an ideology to support the new state rooted in their own interpretation of what they considered revolutionary ideals of Irish-Ireland nationalism.
Racial resentment and support for COVID-19 travel bans in the United States
Authors: Gadarian Shana Kushner , Goodman Sara Wallace , Pepinsky Thomas
Published: May 2023

Travel bans were a globally prevalent policy response to the COVID-19 pandemic. In the United States, travel bans against China and European countries proved a broadly popular mitigation tool among Americans. Why did Americans support COVID-19 travel bans? We fielded two novel survey experiments, surveying 3000 American citizens across five waves (between March 2020 and March 2021). In randomizing the country of origin of those potentially subject to travel ban measures, we find consistent evidence that racial attitudes drive support for travel bans. The strength of this relationship varies across political parties and across hypothetical target countries but is not explained by objective caseloads that change across countries and over the course of the pandemic.
Stenting of native right ventricular outflow tract obstructions in symptomatic infants: histological work-up of explanted specimen
Authors: Happel Christoph M. , Bertram Harald , Kretschmar Oliver , Eildermann Katja , Schmiady Martin O. , Sigler Matthias
Published: May 2023

Background:

Stenting of stenotic right ventricular outflow tract is a palliative measure for severely impaired small babies with Tetralogy of Fallot or similar pathologies. Little is known about the histopathological fate of the stents in the right ventricular outflow tract.

Methods:

Eight samples of surgically removed right ventricular outflow tract stents were histologically analysed according to a predefined protocol.

Results:

The most frequent diagnosis was Tetralogy of Fallot in four patients, pulmonary atresia with ventricular septal defect in two patients, double outlet right ventricle with pulmonary obstruction in one patient, and muscular obstruction of the right ventricular outflow tract in one patient with a syndromic disease with hypertrophic cardiomyopathy. Stents mean implantation duration was 444 days ranging from 105 to 1117 days (median 305.5 days). Histology revealed a variable degree of pseudointima formation consisting of fibromuscular cells surrounded by extracellular matrix. Four of the specimen contained adjacent myocardial tissue fragments, which showed regressive changes. Neither myocardium nor pseudointima tissue or tissue parts locally related to stent struts were infiltrated by inflammatory cells.

Conclusions:

Histological analysis after explantation of early-in-life implanted right ventricular outflow tract stents revealed predominantly pronounced neo-intimal proliferation with a visible endothelial layer, no signs of inflammation, and no prolapse of muscular tissue through the stent struts. Thus, implantation of stents in early life seems to interfere little with the hosts’ immune system and might help to open up the right ventricular outflow tract by mechanical forces and regressive changes in adjacent muscular tissue.
Socio-economic and agricultural factors associated with stunting of under 5-year children: findings from surveys in mountains, dry zone and delta regions of rural Myanmar (2016–2017)
Authors: Htet Min Kyaw , Do Tran Thanh , Wah Thet , Zin Thant , Hmone Myat Pan , Raihana Shahreen , Kirkwood Elizabeth , Hlaing Lwin Mar , Dibley Michael J
Published: May 2023

Objective:

The study’s objective was to investigate multiple underlying social, economic and agricultural determinants of stunting among under-five children in three distinct ecological areas in rural Myanmar.

Design:

Repeated cross-sectional surveys in three states of Myanmar.

Setting:

Rural households in Chin (mountainous), Magway (plains) and Ayeyarwady (delta).

Participants:

From two purposively selected adjacent townships in each state, we randomly selected twenty villages and, in each village, thirty households with under-five children. Households in the first survey in 2016 were revisited in late 2017 to capture seasonal variations.

Results:

Stunting increased from 40·4 % to 42·0 %, with the highest stunting prevalence in Chin state (62·4%). Univariate Poisson regression showed factors contributing to child stunting varied across the regions. Adjusted Poisson regression models showed that child’s age and short maternal stature (aRR = 1·14 for Chin, aRR = 1·89 for Magway and aRR = 1·86 for Ayeyarwady) were consistently associated with child stunting across three areas. For Chin, village-level indicators such as crop consumption (aRR = 1·18), crop diversity (aRR = 0·82) and land ownership (aRR = 0·89) were significantly associated with stunting. In Magway, the number of household members (aRR = 1·92), wealth status (aRR = 0·46), food security status (aRR = 1·14), land ownership (aRR = 0·85) and in Ayeyarwady, women’s decision-making (aRR = 0·67) and indicators related to hygiene (aRR = 1·13) and sanitation (aRR = 1·45) were associated with stunting.

Conclusions:

Area-specific factors were associated with stunting. Maternal short stature and child age were consistent determinants of stunting. A multi-sectoral local approach, including improvements in transport, is needed to address the intergenerational malnutrition problem.
Amigos de Fibro (Fibro Friends): validation of an e-book to promote health in fibromyalgia
Authors: Antunes Mateus Dias , Schmitt Ana Carolina Basso , Pasqual Marques Amélia
Published: May 2023

Background:

Educational strategies are necessary for the care of patients with fibromyalgia. The objective was to develop and validate an e-book to promote the health of individuals with fibromyalgia.

Methods:

Methodological research in which, initially, through a bibliographic survey, the available publications on the subject were analyzed. Then, this knowledge was used to build the theoretical content addressed, and the art and layout of the e-book were elaborated. In the third phase, validation of the constructed material, content specialists (n = 23), technicians (n =  23) and design specialists (n = 23), and individuals with fibromyalgia (n = 45) evaluated the e-book through the Delphi technique. For data collection, different questionnaires were used, according to the evaluation focus of each participant group, analyzed for reliability using Cronbach’s Alpha (αC) and agreement using the Content Validity Index (CVI).

Results:

In the global assessment of agreement from all groups of judges, the CVI presented a considerable minimum: content (0.79), technical (0.89), design (0.92), and target audience (0.97). Regarding reliability, all groups also had a αC within the acceptable range: content (0.960), technical (0.963), design (0.977), and target audience (1.08).

Conclusions:

The e-book was developed and validated in terms of content and relevance and can be used to promote the health of individuals with fibromyalgia.
High-efficiency broadband power amplifier with split-ring resonator second harmonic output matching network
Authors: Song Yu , Liu Guohua , Cheng Zhiqun
Published: May 2023

In this paper, a realization method for high-efficiency broadband power amplifier (PA) based on split-ring resonator (SRR) second harmonic output matching network (SHOMN) is presented. The SRR is composed of double rectangular rings, and it can flexibly match the second harmonic components to the high-efficiency impedance region in the Smith chart in a wide frequency band. Besides, the impedance transformation characteristic of SRR is derived, and the optimal output impedance is converted from the transistor drain to the output of SHOMN for accurate fundamental matching. For validation, a PA operating in 1.2–3.0 GHz is designed and fabricated for a 10-W GaN transistor. The measurement results show that the maximum efficiency can reach 78.3%; meanwhile, the average saturated output power is 41.0 dBm.
Shift in Peaks of PAH‐Associated Health Risks From East Asia to South Asia and Africa in the Future
Authors: Lou Sijia , Shrivastava Manish , Ding Aijun , Easter Richard C. , Fast Jerome D. , Rasch Philip J. , Shen Huizhong , Massey Simonich Staci L. , Smith Steven J. , Tao Shu , Zelenyuk Alla
Published: May 2023

Lung cancer risk from exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is expected to change significantly by 2050 compared to 2008 due to changes in climate and emissions. Integrating a global atmospheric chemistry model, a lung cancer risk model, and plausible future emissions trajectories of PAHs, we assess how global PAHs and their associated lung cancer risk will likely change in the future. Benzo(a)pyrene (BaP) is used as an indicator of cancer risk from PAH mixtures. From 2008 to 2050, the population‐weighted global average BaP concentrations under all RCPs consistently exceeded the WHO‐recommended limits, primarily attributed to residential biofuel use. Peaks in PAH‐associated incremental lifetime cancer risk shift from East Asia (4 × 10−5) in 2008 to South Asia (mostly India, 2–4 × 10−5) and Africa (1–2 × 10−5) by 2050. In the developing regions of Africa and South Asia, PAH‐associated lung cancer risk increased by 30–64% from 2008 to 2050, due to increasing residential energy demand in households for cooking, heating, and lighting, the continued use of traditional biomass use, increases in agricultural waste burning, and forest fires, accompanied by rapid population growth in these regions. Due to more stringent air quality policies in developed countries, their PAH lung cancer risk substantially decreased by ∼80% from 2008 to 2050. Climate change is likely to have minor effects on PAH lung cancer risk compared to the impact of emissions. Future policies, therefore, need to consider efficient combustion technologies that reduce air pollutant emissions, including incomplete combustion products such as PAH.
The Contribution of Microrefugia to Landscape Thermal Inertia for Climate‐Adaptive Conservation Strategies
Authors: Thorne J. H. , Boynton R. M. , Hollander A. D. , Flint L. E. , Flint A. L. , Urban D.
Published: May 2023

Current temperatures in microrefugia may persist longer than in nearby areas as temperatures warm. However, locating and measuring the contribution of microrefugia to thermal inertia in a landscape is challenging. We measured the thermal buffering capacity of microrefugia across a 40,000 km2 region of complex mountain topography by quantifying environmental lapse rate and solar radiation effects on air temperature in 0.1 km2 hexagons, a resource management‐relevant scale for climate adaptation. The greatest buffering capacity is −1.62°C, and only 2.8% of the region can buffer 1°C or greater. Historical loss of local cooling capacity is low, but by 2069 only 6.9%–11% of the region retains baseline temperature conditions. This thermal buffer index can find the most climate change‐buffered areas in lands identified as high priority for habitat conservation, wildlife corridors, and forest preservation. Other processes such as cold air pooling can complement our approach but depend on additional factors.
Buried Alive: Imaging the 9 November 2022, Mw 5.5 Earthquake Source on the Offshore Adriatic Blind Thrust Front of the Northern Apennines (Italy)
Authors: Maesano F. E. , Buttinelli M. , Maffucci R. , Toscani G. , Basili R. , Bonini L. , Burrato P. , Fedorik J. , Fracassi U. , Panara Y. , Tarabusi G. , Tiberti M. M. , Valensise G. , Vallone R. , Vannoli P.
Published: May 2023

The prompt identification of faults responsible for moderate‐to‐large earthquakes is fundamental for understanding the likelihood of further, potentially damaging events. This is increasingly challenging when the activated fault is an offshore buried thrust, where neither coseismic surface ruptures nor GPS/InSAR deformation data are available after an earthquake. We show that on 9 November 2022, an Mw 5.5 earthquake offshore Pesaro ruptured a portion of the buried Northern Apennines thrust front (the Cornelia thrust system [CTS]). By post‐processing and interpreting the seismic reflection profiles crossing this thrust system, we determined that the activated fault (CTS) is an arcuate 30‐km‐long, NW‐SE striking, SW dipping thrust and that older structures at its footwall possibly influenced its position and geometry. The activation of adjacent segments of the thrust system is a plausible scenario that deserves to be further investigated to understand the full earthquake potential of this offshore seismogenic source.
Evapotranspiration of Residential Lawns Across the United States
Authors: Grijseels Noortje H. , Litvak Elizaveta , Avolio Meghan L. , Bratt Anika R. , Cavender‐Bares Jeannine , Groffman Peter M. , Hall Sharon J. , Hobbie Sarah E. , Lerman Susannah B. , Morse Jennifer L. , Narango Desiree L. , Neill Christopher , O'Neil‐Dunne Jarlath , Padullés Cubino Josep , Trammell Tara L. E. , Pataki Diane E.
Published: May 2023

Despite interest in the contribution of evapotranspiration (ET) of residential turfgrass lawns to household and municipal water budgets across the United States, the spatial and temporal variability of residential lawn ET across large scales is highly uncertain. We measured instantaneous ET (ETinst) of lawns in 79 residential yards in six metropolitan areas: Baltimore, Boston, Miami, Minneapolis‐St. Paul (mesic climates), Los Angeles and Phoenix (arid climates). Each yard had one of four landscape types and management practices: traditional lawn‐dominated yards with high or low fertilizer input, yards with water‐conserving features, and yards with wildlife‐friendly features. We measured ETinst in situ during the growing season using portable chambers and identified environmental and anthropogenic factors controlling ET in residential lawns. For each household, we used ETinst to estimate daily ET of the lawn (ETdaily) and multiplied ETdaily by the lawn area to estimate the total volume of water lost through ET of the lawn (ETvol). ETdaily varied from 0.9 ± 0.4 mm d1 in mesic cities to 2.9 ± 0.7 mm d−1 in arid cities. Neither ETinst nor ETdaily was significantly influenced by yard landscape types and ETinst patterns indicated that lawns may be largely decoupled from regional rain‐driven climate patterns. ETvol ranged from ∼0 L d−1 to over 2,000 L d−1, proportionally increasing with lawn area. Current irrigation and lawn management practices did not necessarily result in different ETinst or ETdaily among traditional, water‐conserving, or wildlife‐friendly yards, but smaller lawn areas in water‐conserving and wildlife‐friendly yards resulted in lower ETvol.
Optimizing the Implementation Plan of Watershed Best Management Practices With Time‐Varying Effectiveness Under Stepwise Investment
Authors: Shen Shen , Qin Cheng‐Zhi , Zhu Liang‐Jun , Zhu A‐Xing
Published: May 2023

Optimizing the spatial configuration of diverse best management practices (BMPs) can provide valuable decision‐making support for comprehensive watershed management. Most existing methods focus on selecting BMP types and locations but neglect their implementation time or order in management scenarios, which are often investment‐restricted. This study proposes a new simulation‐optimization framework for determining the implementation plan of BMPs by using the net present value to calculate the economic costs of BMP scenarios and the time‐varying effectiveness of BMPs to evaluate the environmental effectiveness of BMP scenarios. The proposed framework was implemented based on a Spatially Explicit Integrated Modeling System and demonstrated in an agricultural watershed case study. This case study optimized the implementation time of four erosion control BMPs in a specific spatial configuration scenario under a 5‐year stepwise investment process. The proposed method could effectively provide more feasible BMP scenarios with a lower overall investment burden with only a slight loss of environmental effectiveness. Time‐varying BMP effectiveness data should be gathered and incorporated into watershed modeling and scenario optimization to better depict the environmental improvement effects of BMPs over time. The proposed framework was sufficiently flexible to be applied to other technical implementations and extensible to more actual application cases with sufficient BMP data. Overall, this study demonstrated the basic idea of extending the spatial optimization of BMPs to a spatiotemporal level by considering stepwise investment, emphasizing the value of integrating physical geographic processes and anthropogenic influences.
Pore‐Scale Determination of Residual Gas Remobilization and Critical Saturation in Geological CO2 Storage: A Pore‐Network Modeling Approach
Authors: Moghadasi Ramin , Foroughi Sajjad , Basirat Farzad , R. McDougall Steven , Tatomir Alexandru , Bijeljic Branko , Blunt Martin J. , Niemi Auli
Published: May 2023

Remobilization of residually trapped CO2 can occur under pressure depletion, caused by any sort of leakage, brine extraction for pressure maintenance purposes, or simply by near wellbore pressure dissipation once CO2 injection has ceased. This phenomenon affects the long‐term stability of CO2 residual trapping and should therefore be considered for an accurate assessment of CO2 storage security. In this study, pore‐network modeling is performed to understand the relevant physics of remobilization. Gas remobilization occurs at a higher gas saturation than the residual saturation, the so‐called critical saturation; the difference is called the mobilization saturation, a parameter that is a function of the network properties and the mechanisms involved. Regardless of the network type and properties, Ostwald ripening tends to slightly increase the mobilization saturation, thereby enhancing the security of residual trapping. Moreover, significant hysteresis and reduction in gas relative permeability is observed, implying slow reconnection of the trapped gas clusters. These observations are safety enhancing features, due to which the remobilization of residual CO2 is delayed. The results, consistent with our previous analysis of the field‐scale Heletz experiments, have important implications for underground gas and CO2 storage. In the context of CO2 storage, they provide important insights into the fate of residual trapping in both the short and long term.
Uncertainty in Projected Critical Soil Moisture Values in CMIP6 Affects the Interpretation of a More Moisture‐Limited World
Authors: Hsu Hsin , Dirmeyer Paul A.
Published: May 2023

Evaporation is controlled by soil moisture (SM) availability when conditions are not extremely wet. In such a moisture‐limited regime, land‐atmosphere coupling is active, and a chain of linked processes allow land surface anomalies to affect weather and climate. How frequently any location is in a moisture‐limited regime largely determines the intensity of land feedbacks on climate. Conventionally this has been quantified by shifting probability distributions of SM, but the boundary between moisture‐limited and energy‐limited regimes, called the critical soil moisture (CSM) value, can also change. CSM is an emergent property of the land‐atmosphere system, determined by the balance of radiative, thermal and kinetic energy factors. We propose a novel framework to separate the contributions of these separate effects on the likelihood that SM lies in the moisture‐limited regime. We confirm that global warming leads to a more moisture‐limited world. This is attributed to reduced SM in most regions: the moisture effect. CSM changes mainly due to shifts in the surface energy budget, significantly affecting 27.7% of the globe in analyzed climate change simulations. However, consistency among Earth system models regarding CSM change is low. The poor agreement hints that variability of CSM in models and the factors that determine CSM are not well represented. The fidelity of CSM in Earth system models has been overlooked as a factor in water cycle projections. Careful assessment of CSM in nature and for model development should be a priority, with potential benefits for multiple research fields including meteorology, hydrology, and ecology.
Obesity-related complications, healthcare resource use and weight loss strategies in six European countries: the RESOURCE survey
Authors: Evans Marc , de Courcy Joanna , de Laguiche Elisabeth , Faurby Mads , Haase Christiane Lundegaard , Matthiessen Kasper Sommer , Moore Adam , Pearson-Stuttard Jonathan
Published: May 2023

Background

Obesity-related complications (ORCs), such as type 2 diabetes (T2D) and cardiovascular disease, contribute considerably to the clinical and economic impacts of obesity. To obtain a holistic overview of health and weight management attempts for people with obesity in Europe, we designed the cross-sectional RESOURCE survey to collect data on comorbidities, healthcare resource use (HCRU) and weight loss strategies from people with obesity in France, Germany, Italy, Spain, Sweden and the UK.

Methods

Adults (≥18 years old) with self-reported body mass index (BMI) ≥30 kg/m2 who reported interacting with primary or secondary healthcare services in the past 12 months, but had not been pregnant during this time, were recruited from an existing consumer research panel. All data were self-reported via an online survey (May–June 2021). Weight changes over the past year were calculated from participants’ estimated weights.

Results

Of the 1850 participants in the survey, 26.3% reported that they had ≥3 ORCs from a set of 15 conditions of interest. The most frequently reported ORCs were hypertension (39.3% of participants), dyslipidaemia (22.8%) and T2D (17.5%). Participants in obesity class III (BMI 40 to <70 kg/m2) were more likely to report multiple ORCs than those in lower obesity classes. The presence of multiple ORCs was linked to various types of HCRU, including a significantly increased chance of reporting hospitalization in the past year. Most participants (78.6%) had attempted to lose weight in the past year, but of those who also reported estimated weight changes, 73.4% had not experienced clinically meaningful weight loss of ≥5%.

Conclusions

ORCs are common in people with obesity, and are linked to increased HCRU. Together with the low reported success rate of weight loss attempts, this highlights an unmet need in Europe for enhanced weight management support for people with obesity.
Highly stable integration of graphene Hall sensors on a microfluidic platform for magnetic sensing in whole blood
Authors: Shah Nishal , Iyer Vasant , Zhang Zhiping , Gao Zhaoli , Park Juhwan , Yelleswarapu Venkata , Aflatouni Firooz , Charlie Johnson A. T. , Issadore David
Published: May 2023

The detection and analysis of rare cells in complex media such as blood is increasingly important in biomedical research and clinical diagnostics. Micro-Hall detectors (μHD) for magnetic detection in blood have previously demonstrated ultrahigh sensitivity to rare cells. This sensitivity originates from the minimal magnetic background in blood, obviating cumbersome and detrimental sample preparation. However, the translation of this technology to clinical applications has been limited by inherently low throughput (<1 mL/h), susceptibility to clogging, and incompatibility with commercial CMOS foundry processing. To help overcome these challenges, we have developed CMOS-compatible graphene Hall sensors for integration with PDMS microfluidics for magnetic sensing in blood. We demonstrate that these graphene μHDs can match the performance of the best published μHDs, can be passivated for robust use with whole blood, and can be integrated with microfluidics and sensing electronics for in-flow detection of magnetic beads. We show a proof-of-concept validation of our system on a silicon substrate and detect magnetic agarose beads, as a model for cells, demonstrating promise for future integration in clinical applications with a custom CMOS chip.
Risk-reducing surgery for individuals with cancer-predisposing germline pathogenic variants and no personal cancer history: a review of current UK guidelines
Authors: McCarthy Rebecca L. , Copson Ellen , Tapper William , Bolton Helen , Mirnezami Alex H. , O’Neill J. Robert , Patel Nimesh N. , Tischkowitz Marc , Cutress Ramsey I.
Published: May 2023

Identifying healthy carriers of germline pathogenic variants in high penetrance cancer susceptibility genes offers the potential for risk-reducing surgery. The NHS England National Genomic Test Directory offers germline and somatic testing to patients with certain cancers or rare and inherited diseases, or, in some cases, to their relatives. This review summarises current UK guidelines for risk-reducing surgical interventions available for individuals with no personal history of cancer, who are determined to carry germline pathogenic variants. An electronic literature search of NICE guidelines and PubMed citable articles was performed. NICE guidelines are available for bilateral mastectomy and are currently in development for risk-reducing bilateral salpingo-oophorectomy. Guidelines developed with affiliation to, or through relevant British Surgical Societies or international consensus, are available for risk-reducing hysterectomy, polypectomy, gastrectomy, and thyroidectomy. There is a disparity in the development and distribution of national guidelines for interventions amongst tumour types. Whilst we are focusing on UK guidelines, we anticipate they will be relevant much more generally and so of interest to a wider audience including where there are no national guidelines to refer to. We suggest that, as genetic testing becomes rapidly more accessible, guideline development for interventions should be more closely aligned to those for testing.
Demographics, clinical presentation and risk factors of ocular surface squamous neoplasia at a tertiary hospital, South Africa
Authors: Hӧllhumer Roland , Michelow Pamela , Williams Susan
Published: May 2023

Aims

The aim of this study is to describe the demographic, presenting features and associated risk factors of ocular surface squamous neoplasia (OSSN) at a tertiary eye hospital in Johannesburg, South Africa.

Methods

An interventional prospective study of patients presenting with conjunctival masses was conducted. An electronic questionnaire was completed to document demographic data, presenting history, and associated risk factors. A slit lamp examination and photos were used to document and describe the clinical features at presentation. Cases (OSSN) and controls (benign lesions) were determined by histology.

Results

There were 130 cases and 45 controls. Median age was 44 years (IQR: 35–51) with an equal gender distribution in cases. The prevalence of HIV in cases was 74% and was strongly associated with OSSN (p < 0.001). Vascularisation, leukoplakia and pigmentation were clinical features that distinguished cases from controls. A fibrovascular morphology was strongly associated with a benign histology (p < 0.001), whereas leukoplakic and gelatinous morphologies were associated with OSSN. Conjunctival intra-epithelial neoplasia made up 82% of cases.

Conclusion

Our study describes a sample of OSSN that is young and has no gender predisposition. The majority of cases presented with CIN lesions, rather than SCC reported in other African countries. HIV was the most significant risk factor in this study population.
Digital health, digital medicine, and digital therapeutics in cardiology: current evidence and future perspective in Japan
Authors: Nomura Akihiro
Published: May 2023

Ten years passed since Japan set out the Action Plan of Growth Strategy that declared the initiatives of digitalization for medicine, nursing care, and healthcare to achieve the world’s most advanced medical care. The initiatives formed the foundation of the Japanese national strategy and have been continuously refined, resulting in the current environment of digital health and digital medicine. Digital health–related terminologies are organized, such as “digital health,” “digital medicine,” and “digital therapeutics” (DTx), as well as several common digital technologies, including artificial intelligence, machine learning, and mobile health (mHealth). DTx is included in mHealth and is a novel disease treatment option. Also, this article thoroughly describes DTx in Japan and compares it with those in the US and Germany, the leading countries in digital health–related policies, regulations, and their development status. In Japan, two of three DTx applications that have been approved and reimbursed by the Ministry of Health, Labor, and Welfare are explained in detail in relation to cardiovascular medicine. When added to a standard smoking cessation program, the DTx system for nicotine dependence significantly improved the continuous abstinence rate. Moreover, the DTx for hypertension together with the guideline-based hypertension management was effective in patients aged 65 years or younger who were diagnosed with essential hypertension without antihypertensive agents, and it was also found to be cost-effective. DTx in cardiovascular medicine, with consideration on safety, efficacy, and cost-effectiveness, could be widely used not only through basic experiments and clinical studies but also through social implementation.
Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation
Authors: Pagliuca Simona , Gurnari Carmelo , Hercus Colin , Hergalant Sébastien , Hong Sanghee , Dhuyser Adele , D’Aveni Maud , Aarnink Alice , Rubio Marie Thérèse , Feugier Pierre , Ferraro Francesca , Carraway Hetty E. , Sobecks Ronald , Hamilton Betty K. , Majhail Navneet S. , Visconte Valeria , Maciejewski Jaroslaw P.
Published: May 2023

Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia, whereby donor T- effector cells recognize leukemia neoantigens. However, a substantial fraction of patients experiences relapses because of the failure of the immunological responses to control leukemic outgrowth. Here, through a broad immunogenetic study, we demonstrate that germline and somatic reduction of human leucocyte antigen (HLA) heterogeneity enhances the risk of leukemic recurrence. We show that preexistent germline-encoded low evolutionary divergence of class II HLA genotypes constitutes an independent factor associated with disease relapse and that acquisition of clonal somatic defects in HLA alleles may lead to escape from GvL control. Both class I and II HLA genes are targeted by somatic mutations as clonal selection factors potentially impairing cellular immune responses and response to immunomodulatory strategies. These findings define key molecular modes of post-transplant leukemia escape contributing to relapse.
Hydrogenase-based oxidative biocatalysis without oxygen
Authors: Al-Shameri Ammar , Siebert Dominik L. , Sutiono Samuel , Lauterbach Lars , Sieber Volker
Published: May 2023

Biocatalysis-based synthesis can provide a sustainable and clean platform for producing chemicals. Many oxidative biocatalytic routes require the cofactor NAD+ as an electron acceptor. To date, NADH oxidase (NOX) remains the most widely applied system for NAD+ regeneration. However, its dependence on O2 implies various technical challenges in terms of O2 supply, solubility, and mass transfer. Here, we present the suitability of a NAD+ regeneration system in vitro based on H2 evolution. The efficiency of the hydrogenase-based system is demonstrated by integrating it into a multi-enzymatic cascade to produce ketoacids from sugars. The total NAD+ recycled using the hydrogenase system outperforms NOX in all different setups reaching up to 44,000 mol per mol enzyme. This system proves to be scalable and superior to NOX in terms of technical simplicity, flexibility, and total output. Furthermore, the system produces only green H2 as a by-product even in the presence of O2.
Cryo-EM structure of the folded-back state of human β-cardiac myosin
Authors: Grinzato Alessandro , Auguin Daniel , Kikuti Carlos , Nandwani Neha , Moussaoui Dihia , Pathak Divya , Kandiah Eaazhisai , Ruppel Kathleen M. , Spudich James A. , Houdusse Anne , Robert-Paganin Julien
Published: May 2023

To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’ state when exertion is increased. The ‘off’ state is equated with a folded-back structure known as the interacting-heads motif (IHM), which is a regulatory feature of all class-2 muscle and non-muscle myosins. We report here the human β-cardiac myosin IHM structure determined by cryo-electron microscopy to 3.6 Å resolution, providing details of all the interfaces stabilizing the ‘off’ state. The structure shows that these interfaces are hot spots of hypertrophic cardiomyopathy mutations that are thought to cause hypercontractility by destabilizing the ‘off’ state. Importantly, the cardiac and smooth muscle myosin IHM structures dramatically differ, providing structural evidence for the divergent physiological regulation of these muscle types. The cardiac IHM structure will facilitate development of clinically useful new molecules that modulate IHM stability.
Palladium-catalyzed regiodivergent hydrochlorocarbonylation of alkenes for formation of acid chlorides
Authors: Wu Fei , Wang Bo , Li Na-Qi , Yang Hui-Yi , Ren Zhi-Hui , Guan Zheng-Hui
Published: May 2023

Novel strategy for acid chlorides formation that do not use carboxylic acids is particularly attractive in chemical synthesis but remains challenging. Herein, we reported the development of a highly effective Pd-catalyzed hydrochlorocarbonylation of alkenes with CO for the formation of alkyl acid chlorides. Chlorosilane and AcOH were found as a mild HCl source for the reaction. The reaction shows broad substrate scope and produces both branched and linear alkyl acid chlorides in good to high yields upon different ligands and solvents. Cooperating with follow-up acylation reactions, the Pd-catalyzed hydrochlorocarbonylation offers a complementary platform for the synthesis of diverse carbonyl compounds from alkenes. Mechanistic investigations suggested that the reaction proceeded though a palladium hydride pathway, and CO prompted reductive elimination of the acyl-Pd-Cl intermediate.
Thermal disruption of a Luttinger liquid
Authors: Cavazos-Cavazos Danyel , Senaratne Ruwan , Kafle Aashish , Hulet Randall G.
Published: May 2023

The Tomonaga–Luttinger liquid (TLL) theory describes the low-energy excitations of strongly correlated one-dimensional (1D) fermions. In the past years, a number of studies have provided a detailed understanding of this universality class. More recently, theoretical investigations that go beyond the standard low-temperature, linear-response TLL regime have been developed. While these provide a basis for understanding the dynamics of the spin-incoherent Luttinger liquid, there are few experimental investigations in this regime. Here we report the observation of a thermally induced, spin-incoherent Luttinger liquid in a 6Li atomic Fermi gas confined to 1D. We use Bragg spectroscopy to measure the suppression of spin-charge separation and the decay of correlations as the temperature is increased. Our results probe the crossover between the coherent and incoherent regimes of the Luttinger liquid and elucidate the roles of the charge and the spin degrees of freedom in this regime.
CASPI: collaborative photon processing for active single-photon imaging
Authors: Lee Jongho , Ingle Atul , Chacko Jenu V. , Eliceiri Kevin W. , Gupta Mohit
Published: May 2023

Image sensors capable of capturing individual photons have made tremendous progress in recent years. However, this technology faces a major limitation. Because they capture scene information at the individual photon level, the raw data is sparse and noisy. Here we propose CASPI: Collaborative Photon Processing for Active Single-Photon Imaging, a technology-agnostic, application-agnostic, and training-free photon processing pipeline for emerging high-resolution single-photon cameras. By collaboratively exploiting both local and non-local correlations in the spatio-temporal photon data cubes, CASPI estimates scene properties reliably even under very challenging lighting conditions. We demonstrate the versatility of CASPI with two applications: LiDAR imaging over a wide range of photon flux levels, from a sub-photon to high ambient regimes, and live-cell autofluorescence FLIM in low photon count regimes. We envision CASPI as a basic building block of general-purpose photon processing units that will be implemented on-chip in future single-photon cameras.
Curvature-controlled band alignment transition in 1D van der Waals heterostructures
Authors: Zhao Shu , Yang Chunxia , Zhu Ziye , Yao Xiaoping , Li Wenbin
Published: May 2023

The effect of curvature on the band alignment of one-dimensional (1D) van der Waals (vdW) transition metal dichalcogenide (TMDC) heterostructures is studied by comprehensive first-principles calculations. We find that, as the diameter of a TMDC nanotube decreases, the combined effect of curvature-induced flexoelectricity and circumferential tensile strain causes a rapid lowering of the conduction band minimum, whereas the valence band maximum exhibits an initial lowering before rising. As individual TMDC nanotubes form coaxial heterostructures, the concerted effect of diameter-dependent band-edge levels and intertube coupling via flexovoltage can result in a transition of intertube band alignment from Type II to Type I in multiple heterostructural systems, including large-diameter MoSe2@WS2, MoTe2@MoSe2, and MoTe2@WS2 heterostructures. These results lay down a foundation for the rational design of 1D vdW heterostructures.
Identification of PLOD3 and LRRN3 as potential biomarkers for Parkinson’s disease based on integrative analysis
Authors: Guo Xing , Hu Wenjun , Gao Zijie , Fan Yang , Wu Qianqian , Li Weiguo
Published: May 2023

Parkinson’s disease (PD) is one of the most prevalent movement disorders and its diagnosis relies heavily on the typical clinical manifestations in the late stages. This study aims to screen and identify biomarkers of PD for earlier intervention. We performed a differential analysis of postmortem brain transcriptome studies. Weighted Gene Co-expression Network Analysis (WGCNA) was used to identify biomarkers related to Braak stage. We found 58 genes with significantly different expression in both PD brain tissue and blood samples. PD gene signature and risk score model consisting of nine genes were constructed using least absolute shrinkage and selection operator regression (LASSO) and logistic regression. PLOD3 and LRRN3 in gene signature were identified to serve as key genes as well as potential risk factors in PD. Gene function enrichment analysis and evaluation of immune cell infiltration revealed that PLOD3 was implicated in suppression of cellular metabolic function and inflammatory cell infiltration, whereas LRRN3 exhibited an inverse trend. The cellular subpopulation expression of the PLOD3 and LRRN3 has significant distributional variability. The expression of PLOD3 was more enriched in inflammatory cell subpopulations, such as microglia, whereas LRRN3 was more enriched in neurons and oligodendrocyte progenitor cells clusters (OPC). Additionally, the expression of PLOD3 and LRRN3 in Qilu cohort was verified to be consistent with previous results. Collectively, we screened and identified the functions of PLOD3 and LRRN3 based the integrated study. The combined detection of PLOD3 and LRRN3 expression in blood samples can improve the early detection of PD.
Hole-type superconducting gatemon qubit based on Ge/Si core/shell nanowires
Authors: Zhuo Enna , Lyu Zhaozheng , Sun Xiaopei , Li Ang , Li Bing , Ji Zhongqing , Fan Jie , Bakkers E.P.A.M. , Han Xiaodong , Song Xiaohui , Qu Fanming , Liu Guangtong , Shen Jie , Lu Li
Published: May 2023

We demonstrate that superconducting gatemon qubits based on superconductor-semiconductor-superconductor Josephson junctions can be constructed on hole-type Ge/Si core/shell nanowires. The frequency of the qubit can be set firstly by controlling the diffusion of Al in the nanowire via thermal annealing, which yields a suitable critical supercurrent allowing the qubit frequency to be within the experimentally accessible range, and then by fine tuning of a gate voltage, by which an accurate adjustment of the frequency can be realized. On the resulted qubit, Rabi oscillation with an energy relaxation time $${T}_{1} \sim 180\,{\rm{ns}}$$

T

1

~
180

ns

was observed in the time domain, an average decoherence time $${T}_{2}^{* } \sim 15\,{\rm{ns}}$$

T

2

*

~
15

ns

was obtained, and the gate voltage dependence of both $${T}_{1}$$

T

1

and $${T}_{2}^{* }$$

T

2

*

was investigated. Such a hole-type superconducting gatemon qubit, based on materials with strong spin-orbit coupling and potentially the absence of hyperfine interaction after isotope purification, could be used for exploring the quantum coherence phenomena of hole-gas and even Majorana physics in Ge-based quantum devices.
Realization of practical eightfold fermions and fourfold van Hove singularity in TaCo2Te2
Authors: Rong Hongtao , Huang Zhenqiao , Zhang Xin , Kumar Shiv , Zhang Fayuang , Zhang Chengcheng , Wang Yuan , Hao Zhanyang , Cai Yongqing , Wang Le , Liu Cai , Ma Xiaoming , Guo Shu , Shen Bing , Liu Yi , Cui Shengtao , Shimada Kenya , Wu Quansheng , Lin Junhao , Yao Yugui , Wang Zhiwei , Xu Hu , Chen Chaoyu
Published: May 2023

Space groups describing the symmetry of lattice structure allow the emergence of fermionic quasiparticles with various degeneracy in the band structure. Theoretical efforts have predicted many materials hosting fermions with the highest degeneracy, i.e., eightfold fermions, yet lacking experimental realization. Here, we explore the band degeneracies in TaCo2Te2 crystals. Through systematic experimental and theoretical analyses, we establish TaCo2Te2 as a nonsymmorphic crystal with negligible spin–orbit coupling (SOC) and long-range magnetic order. These critical properties guarantee the realization of practical eightfold fermions and fourfold van Hove singularity, as directly observed by photoemission spectroscopy. TaCo2Te2 serves as a topological quantum critical platform, which can be tuned into various magnetic, topologically trivial, and nontrivial phases by adding strain, magnetic field, or SOC. The latter is demonstrated by our first-principles calculations, which show that enhancing SOC in TaCo2Te2 will promote the experimental observation of bulk hourglass fermions. Our results establish TaCo2Te2 as a platform to explore the interplay between symmetry and band topology.