bluuebunny/crossref_metadata_2025 huggingface dataset:
The possibility of provision of hygienically safe residing for the population in residential construction located closely to air transport enterprises
Authors: Gildenskiold R. S. , Tatyanyuk Tatyana K. , Savelyev S. I. , Rekis V. K.
Published: November 2019

Operation of the modern heavy aircraft on the surrounding vast territory is associated with the appearance of high levels of sound pressure generated by the powerful engines, especially during takeoff and landing operations. Currently, the elimination or significant reduction of noise pollution on the environment technically does not yet have a radical solution and the possible reduction of the impact ofnoise pollution on the residents ofnearby settlements is achievedfor residents of building by the optimal location of the runway, changing in conditions for the takeoff and landing of aircrafts, the ordering of the regimen of the airport, the introduction of the package sufficiently effective anti-noise diverse - engineering, planning activities, in some cases, the creation ofprotective noise shield on the border of the residential area and the construction ofprotective awnings over the children’s and sports fields with fencing shields converted in the direction of the runway. An example of a positive decision, taking into account the complexity and variety of aspects of the problem, it is possible to consider the development of the project plan of the new microdistrict «Eletsky» in the Soviet district of the city of Lipetsk, falling under the impact of aircraft noise of plying aircrafts of the military airfield.
Model of the assessment of the risk of conditions of the work with the use of pesticides: results and development
Authors: Rakitsky V. N. , Bereznyak Irina V. , Ilnitskaya A. V.
Published: November 2019

There is implemented the development of the model of assessment of the risk from working conditions/ This model allows to solve the problem of the safe use of pesticides in agricultural production of the Russian Federation. The importance of the parallel assessment of the risk for the specific factor of the external exposure to operators (SF ex.) and absorbed dose (SF int.) is presented. Studies of more than 500 pesticides have shown the following correlation of the SF ex. and SF int.: in 8.3-37.5% cases SF ex. and SF int. were practically equal, in 44.8-85.7% cases SF ex. was higher up to by 10 times and in 8.3-26.3% cases SF int. is higher up to by 30 times. Introduction of the new evaluation criterion SF int. increases reliability of the risk assessment.
Choice of informative laboratory biomarkers for the early identification of changes in neurohumoral regulation and carbohydrate exchange in workers of the mining and mechanical engineering industry
Authors: Lapko Inna V. , Kiryakov V. A. , Pavlovskaya N. A. , Oshkoderov O. A. , Klimkina K. V.
Published: November 2019

The diagnostic significance of hormones and integral indices of pituitary-adrenal, pituitary-thyroid and pituitary-gonadal system and carbohydrate metabolism (ACTH (corticotropin), aldosterone, cortisol, TSH (thyroid-stimulating hormone), free triiodothyronine (fT3), free thyroxine (fT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), total and free testosterone, insulin, integral pituitary-adrenal index (IPAI), the pituitary-thyroid index (PTI), indices of carbohydrate metabolism (Caro and HOMA-IR) was studied for the early diagnostics of disorders of neurohumoral regulation in workers of mining and mechanical engineering industries. The most informative indices, permitting to identify disorders of carbohydrate metabolism are established to be indices of insulin resistance (index Caro and index NOMA-IR) and the determination of insulin in serum. For the identification of changes in pituitary adrenal, pituitary-thyroid and pituitary-gonadal system in patients with vibration disease, sensory-neural hearing loss, comorbidity indexes IGNI, ITI, concentrations of LH and total testosterone are of the most diagnostically significance.
The system of the quality control and the safety of baby food, the prospects of its development
Authors: Georgieva Olga V. , Konovalova L. S. , Kon' I. Ya.
Published: November 2019

In the article there is considered the substantiation of raise demands to the chemical composition of children’s food and indices of their safety, with taking into account the immaturity of metabolic and physiological processes and limitations of “depot” of nutrients in babies. Based on research results of leading experts in the field of children’s nutritiology and according to the recommendations of the Codex Alimentarius of the Commission of FAO/WHO, ESPGHAN Committee on Nutrition, the EFSA recommendations and EUDirectives there were specified requirements for the ingredient composition, content of essential components and indices of the nutritional value of substitutes for human milk and functional products for the nutrition of infants of the first year of life. There are shown stages of the development of the Russian system of hygienic requirements for baby food, and the direction of its harmonization with international and European standards, particularly for substitutes for human milk and products of dietary therapeutic and dietary preventive nutrition for babies. There are considered aspects of the introduction ofproducts and weaning food dishes into the food ration of infants. There is presented the classification ofproducts of children’s food and the assortment of each group of weaning foods. There is provided the modern legislative framework in the field of the quality and safety for infant nutrition. There was shown the difference between domestic legislation and regulatory framework of the EurAsEC Customs Union of the European countries in the field offood products safety for children older three years. There are presented proposals on the creation of the single regulatory base within the framework of the EurAsEC Customs Union for control the quality and safety of all the baby foods
Determination of priority unfavorable environmental factors
Authors: Zaikova Zoya A. , Burdukovskaya A. V. , Belykh A. I.
Published: November 2019

In the Irkutsk region there are recorded high indices of rates of morbidity, disability, mortality rate of the working-age population and low levels of life expectancy of the population, that is confirmed by ranking position levels among the all subjects of the Russian Federation. According to all mentioned indices of health the region is inside the top ten unfavorable regions of Russia. In relation to the problem in the state of health of the adult population the estimation of the causal relationships between environmental factors and certain health indices is actual. The list of studiedfactors included health indices that characterize the harmful working conditions of the working population and basic socioeconomic indices in the region. Estimation of causal-relationship relationships was performed with the use of methods of multivariate analysis - correlation and multiple linear regression. In the selection offactors for the construction of mathematical models of multiple regression there were used methods of the analysis of variables variability, pair correlation coefficients matrix and sequential switching covariates to eliminate the problems of multicollinearity, pre-standardization of indices for the elevation of the numerical stability of regression analysis algorithm. As a result of the execution of the analysis there were constructed statistical models for the dependence in the system variables “environment - public health”, which allowed to identify the most informative regression models for the adult population health according to indices of primary disability of the population, the mortality rate and life expectancy of the working age population. According to results of the analysis there were identified priority factors affecting on the health of the adult population of the Irkutsk region. To these factors there are referred the proportion of workplaces failing to meet sanitary standards for vibration and 8 socio-economic indices of living standards of the population.
Induction of apoptosis in neurons of white rats under exposure of nanobiocomposite based on ag (0) nanoparticles and arabinogalactan
Authors: Sosedova Larisa M. , Novikov M. A. , Titov E. A. , Rukavishnikov V. S.
Published: November 2019

There are presented results of the immunohistochemical study of neural tissue of outbred albino rats exposed for 9 days to the influence of the silver nanobiocomposite consisted of silver nanoparticles encapsulated into a matrix of a natural polymer - arabinogalactan. The research of albino rats was performed in 2 stages: half of the rats in each groups were decapitated immediately after the exposure (early period) and the rest animals - 6 months after the end of exposure (remote period). The impact of the studied substance was proved to cause functional changes in cells of the nervous tissue. After the subacute administration of the nanobiocomposite - argentum-arabinogalactan (nano-Ag-AG) in cells of the nervous tissue of the brain of albino rats the expression of apoptotic and anti-apoptotic protein (caspase-3 and bcl-2) was established to be changed. The number of normal neurons producing protein caspase-3 sharply increases. Herewith the number of immunonegative neurons fairly declines. Along with this there is noted the high level of bcl-2 content, one function ofwhich is the preclusion ofapoptosis. In preparations there is revealed a significant gain in the number of bcl-2 expressing neurons, however, the protective effect of the protein is not fully realized, that leads to the significantly increase in the content of damaged hyperchromatic cells. The evaluation of results of the immunohistochemical study of the nervous tissue of albino rats according to data concerning the proteins caspase-3 and bcl-2 expression permits to make a conclusion about the capability of nanoargentum encapsulated into polymer matrix by passing the blood-brain barrier to induce the triggering apoptosis cascade in neurons of the cerebral cortex.
Medical hydrogeology is an independent interdisciplinary branch of the science about groundwater
Authors: Elpiner Leonid I.
Published: November 2019

The use of groundwater in population water supply systems gains more and more importance because of increasing degradation of the quality of surface water sources. At the same time there are changed concepts on ubiquitous high quality of groundwater. The executed analysis offoreign and domestic literature allowed authors to determine the character and causes of negative changes in the composition of groundwater. In the large body of investigations there were established cause-and-effect relationships between a number of noninfectious (including cardiovascular and cancer) and infectious diseases and anthropogenic pollution and the natural composition of groundwater. In the article there is substantiated the formation of a new interdisciplinary scientific direction - medical hydrogeology. On the basis of current data on the medical and ecological significance of the quality, quantity and regime of the groundwater, geological conditions of the shaping of their composition, there was shown the need of the consideration of the hydrological situation in making water supply management solutions safe for the health of the population. In this regard, there were considered the interrelationship and interdependence of allied disciplines - hygiene, ecological toxicology and epidemiology, hydrogeochemistry, hydrogeology. There was pointed the importance of the acquisition of based on hydrogeology medical specialists of the water supply profile for sharing with hygienists of the effective solution of tasks of the management of groundwater sources.
Study and methodology for research of the life quality in students
Authors: Popov Valery I. , Melikhova E. P.
Published: November 2019

In this article there is reported a comparative analysis of methodological approaches to the assessment of the quality of life. There are present results of studies of quality of life of young students, performed with the use of compared methodological approaches (questionnaires) and allowing to construct the evaluation approach to the study of the quality of life in students.
Laporan Kasus: Patologi Balantidiosis pada Babi
Authors: Purnama Komang Andika , Kardena I Made , Berata I Ketut , Winaya Ida Bagus Oka , Adi Anak Agung Ayu Mirah
Published: November 2019

Balantidium coli (B. coli) adalah salah satu dari parasit protozoa pencernaan yang dapat menginfeksi hewan ternak terutama babi. Hewan yang dijadikan studi kasus adalah seekor babi landrace yang berumur sekitar dua bulan, berasal dari Desa Yeh Gangga Kabupaten Tabanan, Bali. Babi kasus didapatkan dalam keadaan sakit selama tiga hari dengan tanda klinis diare berwarna agak putih dan berlendir, lemas, tidak mau makan, kurus dan akhirnya mati. Perubahan patologi anatomi yang teramati peritonitis, pada kolon dan usus halus mengalami distensi, edema, dan pada mukosa usus perdarahan, terutama pada kolon dan sekum. Pada pemeriksaan histopatologi ditemukan infiltrasi sel radang limfosit dan polimorfonuklear dan ditemukan adanya protozoa B. coli di dalam tunika mukosa sampai tunika sub mukosa kolon. Simpulannya adalah babi terserang penyakit balantidiosis.
O patrimônio industrial no Brasil no século XXI
Authors: Silva Ronaldo André Rodrigues da
Published: November 2019

O cenário de formação de estudos sobre patrimônio industrial no Brasil como foco do trabalho visa apresentar, de maneira preliminar, o atual estágio do estado da arte no País. O envolvimento de acadêmicos, grupos de trabalho e demais pesquisadores determina um conjunto de trabalhos acadêmicos e científicos que tragam a temática à discussão atual e construam um corpus teórico e práticas cuja atenção se centra na temática. A partir dessa ideia constrói-se a base metodológica de pesquisa, como um estudo bibliográfico cujos binômios “patrimônio industrial” e “arqueologia industrial” definem uma rede de correlação e seus preditores. Como campo de pesquisa tem-se os encontros nacionais e internacionais do período de 2004-2018, além das bases de dados de portais acadêmicos no Brasil: o Portal de Periódicos (CAPES/MEC), a Biblioteca Digital Brasileira de Teses e Dissertações (BDTD/IBICT) e o Portal Domínio Público (MEC). O cruzamento das informações determinou uma análise em relação dos campos de pesquisa e áreas pesquisadas ao patrimônio industrial. Assim, busca-se avaliar o campo teórico-prático construído, além de compreender sua inserção em diferentes cenários a partir da segunda década do século XXI. A sua concepção pretende trazer à discussão a importância dos espaços industriais segundo sua importância na formação do patrimônio e da sociedade brasileiros.
Fábrica Wallig do nordeste S.A.
Authors: Melo Alcilia Afonso de Albuquerque
Published: November 2019

Este artigo trata-se de uma análise arquitetônica do complexo industrial que abrigou a Fábrica Wallig Nordeste S.A, localizada no bairro do Distrito Industrial da cidade de Campina Grande, agreste paraibano. Possui como objetivo, refletir sobre a instalação de projetos arquitetônicos oriundos de regiões brasileiras distintas geograficamente, mas que procuraram adaptações aos condicionantes do lugar no qual a obra foi edificada, trabalhando com uma mão de obra local, e procurando soluções construtivas que empregassem materiais e técnicas do território. Na contemporaneidade, observa-se que os acervos modernos e industriais encontram-se em constante risco, e por isso, a importância em refletir sobre a preservação dos mesmos. A edificação/objeto desse artigo- era sede da empresa Wallig Nordeste S.A, uma fábrica de fogões domésticos pertencente ao Grupo Wallig do Rio Grande do Sul. O autor do projeto do grande complexo industrial foi o escritório “Sérgio e Pellegrini Cia Ltda, Estúdio de arquitetura, urbanismo e decorações”, localizado em Porto Alegre, no Rio Grande do Sul e que o apresentou em 1965 para os trâmites legais. A solução projetual denota uma preocupação em resolver os problemas climáticos locais, ao observar-se uma série de soluções que serão abordadas nesse artigo, levando à discussão da estreita relação entre a produção arquitetônica industrial e o lugar. Após o fechamento da fábrica, a edificação manteve-se inutilizada por mais de vinte anos, e somente em 2006, a mesma voltou a ser utilizada, quando foi criado o Condomínio Industrial Wallig que abriga dezesseis microempresas.
PRODUCTIVITY OF HAIRY WATER LILY (Nhymphaea pubescens Will.) SEEDS IN SOUTH KALIMANTAN’S BACKSWAMPS BASED ON LINEAR MODEL
Authors: G Rusmayadi , R Khairina
Published: November 2019

The study on the productivity of water lily seeds in South Kalimantan’s backswamps using Wageningen method and the interview with middle traders could give more information about water lily as food commodity. Rainfall pattern in Tabalong, Hulu Sungai Utara (HSU) and Hulu Sungai Selatan (HSS) regencies is like U letter. U type is sensitive with Monsoon. This Monsoon area is affected by easterly wind and local wind. When the sun is at the south side in October to March, the Monsoon moves from west to south east, and in the other way around in April to September, the wind moves from south east to west. In April, the height of water level in some different areas was the same. The highest water level was in Paharangan subdistrict that could reach more than 100 cm and the lowest was in Hambuku subdistrict, about 80 cm. Based on the interview with middle traders, it was found out that in Hambuku subdistrict and its surrounding area, there was about 1.0 to 1.7 t/ha of water lily seeds each period. In Ampukung, Hambuku and Paharangan subdistricts, the water lily seeds were about 1.121 t/ha, 1.057 t/ha and 0.653 t/ha, respectively. If the paddy fields in Tabalong, HSU and HST regencies are 10,683 ha, 21,2252 ha, and 18,763 ha, respectively, those areas potentially can yield about 11,976.661 t/ha, 224,456.2 t/ha and 12,254.6778 t/ha. Whereas, based on radiation (Rg), the photosynthetically active radiation on very clear days (Ac), in cal cm-2 day-1, and daily gross photosynthesis rate of crop canopies on very clear days (bc) in kg ha-1 day-1 for Pm = 20 kg CH2O ha-1 hr-1, it showed that the yield of hairy water lily seeds in Ampukung, Hambuku and Paharangan subdistricts was 1.1560 t/ha, 1.1425 t/ha and 1.1021 t/ha, respectively. Hairy water lily naturally grows with seeds in soil and water in paddy field, so it can grow, develop, and produce seeds. Therefore, agronomical technique is important for further study.
PLANKTON FERTILITY IN SUPPORTING FISH PRODUCTIVITY IN MONOTONOUS SWAMP IN HULU SUNGAI UTARA REGENCY
Authors: Slamat Slamat
Published: November 2019

This study was carried out in a monotonousswamp in Hulu Sungai Utara Regency, South Kalimantan Province. The purpose was to find out the plankton fertility in supporting fish productivity in the monotonous swamp to build a dynamic waterbody with all of its supporting aspects. The analyses were performed on plankton diversity, water quality parameters and fish production levels from 2009 to 2013. The results of ShannonWiener diversity index analysis for plankton in the swamp approximately exceeded the value (>2), indicating that the water condition was still good and fertile. The water quality parameters in the swamp were specific; blackish brown in color, acid, and having low level of oxygen with high ammonia concentration. The decreasing trends of fish productivity in the swamp were resulted from unselective fish catching, environmental pollutions and land-use changes converting the swamp areas into plantations and housing. Therefore, it is necessary to develop conservation areas to keep the primary productivity of the waterbody in high level, which would affect the increase in the productivity of swamp fish.
MOISTURE RELEASE OF TROPICAL PEAT SOILS AS DECREASING WATER TABLE
Authors: Kurnain Ahmad
Published: November 2019

Hydro-physics of peat soils varied with their peat decomposition degree. One of the important hydro-physics is ability of the peat soil to release water as decreasing water table. Potential of water availabilty to crop growth is evidently related to this behaviour. The present study was conducted to understand modes of moisture release of peat soils as decreasing water table. Water tables were simulated using a hanging column method. The water table was arranged at levels of 0, 10, 20, 30, 50, and 100 cm below peat column surfaces. Potential of moisture release or in oppositely potential of moisture retention could be modelled with the 3 parameter equation. Highly decomposed peat characterized by higher bulk density and lower total porosity stored less water but retained more water.
VARIATION IN VEGETATION COVER OF SHRUB AS A VEGETATION CANDIDATE FOR GREEN OPEN SPACE COMPONENT IN CEMPAKA SUBDISTRICT, BANJARBARU
Authors: Rahmani Dienny Redha , Gunawan Gunawan , Peran Setia Budi
Published: November 2019

Good urban structure and activity require green open space to improve the ecological functions in it, but trees are not fully able to meet the important space in the urban vegetation while woody shrubs have the potential for it. Therefore, the objective of this study was to find out the potential of shrub as the component of urban vegetation so that it can be used as the information regarding the planning for land conversion in Cempaka subdistrict. Three sampling stations with 3 plots of 4x4 m at each station were determined on the basis of green open space data of shrubs in Cempaka subdistrict using a purposive sampling method. The shrub canopy was analyzed and environmental parameters were measured. Data were analyzed using the analysis of canopy volume, Pearson correlation analysis and analysis of Importance Value Index (IVI). The results of shrub vegetation estimation indicated that the volume of shrub vegetation canopy in Cempaka subdistrict was up to 22,462,878.50 m3 while the area with shrubs in the subdistrict was 5,675.116 hectares. Pearson correlation analysis showed that the canopy volume of shrubs in Cempaka subdistrict affected the changes in environmental factors. The most dominant shrub species was Ficus fistulosa Reinw. ex Bl with IVI value of 56.1%. It can be concluded that shrubs have potential as the component of the green space vegetation in urban areas.
SPATIAL DISTRIBUTION OF MANGROVE ECOSYSTEM IN CONSERVATION AREA OF TELUK KELUMPANG NATURE RESERVE
Authors: Asyari Mufidah , Udiansyah Udiansyah
Published: November 2019

Mangrove forest area of 98,494.6 ha (72.86%) is distributed in Kotabaru Regency. Based on the forest status, the mangrove forest consists of a nature reserve zone covering an area of 66,487.5 ha (67.50%), production forests 3,510.4 ha (3.57%), and area for other uses 28,496.7 ha (28.93%) (BKSDA, 2008 the Ministry of Forestry, 2009; Sirang et al., 2010). The purpose of this study was to find out the spatial distribution of mangrove ecosystem in Teluk Kelumpang Nature Reserve. The study was conducted using a remote sensing technology (Landsat 7 ETM + 2012 (Path/Row: 117/063) to obtain data of the extent, and the distribution of mangrove forest species in Teluk Kelumpang nature reserve. The measurement of mangrove vegetation was to find out the potency and characteristics of mangrove forest stands. The results showed that the potential vegetation in the area of Teluk Kelumpang nature reserve was R. apiculata, R. mucronata and B. gymnorhiza. Teluk Kelumpang nature reserve is divided into two zones. The first zone is proximal zone (50 m - 100 m from coastline), a zone dominated by R. apiculata and R. mucronata plants. The second is middle zone, a mixed zone comprising B. gymnorhiza, X. granatum, C. decandra, and N. fruticans, with the area of > 100 m - 500 m from the river line and coastline.
CONTRIBUTION OF FORESTRY SUBSECTOR TO ECONOMIC DEVELOPMENT OF KOTAWARINGIN BARAT REGENCY
Authors: Jumri Jumri , Mayawati Sari
Published: November 2019

Forest as the financial capital for development has important roles in economic development of Kotawaringin Barat Regency. Commonly, forest is a large area of land where flora (trees) and fauna (animals) exist. It can produce woods and other products for human consumption (production function), regulate the water system for human life, prevent flooding and sea water intrusion (protection function), and preserve many species of plants and animals and ecosystem (conservation function). Economically, forest as the source of woods, rattans and other products provided foreign exchange for the country during 1980-1990; this case placed the subsector of forestry as one of the prime movers in Indonesia’s economy. The purpose of this research was to analyze the extent of the foresty’s  contribution to the economic development and social welfare in Kotawaringin Barat Regency. The research methodology was conducted by: a) interview, b) observation / field surveys and c) documentation (supporting data). The results showed that the contribution of forestry subsector in the economic development and social welfare of Kotawaringin Barat reached IDR 38.6 billion in 2011.
PLANKTON COMMUNITY STRUCTURE ON FISH PONDS IN THE RIAM KANAN RIVER OF BANJAR REGENCY
Authors: Ambarwati Rieski , Krisdianto Krisdianto , Slamat Slamat
Published: November 2019

Aquaculture in Riam Kanan river receives watersupply from rivers and Riam Kanan reservoir from upstream to downstream and practices different irrigation and fertilization systems. This study was aimed to compare the plankton community structure, to find out the physicalchemical parameters associated with the abundance of plankton and the fertility of the fish-farming ponds. The research was conducted at Mandiangin Freshwater Aquaculture Center (Balai Budidaya Air Tawar – BBAT), Karang Intan (Balai Benih dan Induk Ikan Air Tawar – BB-IAT) and Cindai Alus Minapolitan area by using the observation method. Water samples were taken by composite of 6 replicates at 12 stations. The parameters measured were temperature, visibility, pH, iron, free ammonia, nitrate, phosphate, DO, BOD and plankton analysis. Data were tested statistically with cluster, Pearson correlation and regression. The result shows that there are differences in plankton community structure in the fish ponds, shown by 5 cluster groups. The abundance of phytoplankton has a significant correlation with pH, temperature, DO, and free ammonia. The abundance of zooplankton also has a significant correlation with pH, DO, BOD, and free ammonia. The seed pond at BBAT Mandiangin is eutrophically dominated by Bacillarophyta and Amoboezoa, while in BB-IAT Karang Intan and Cindai Alus are dominated by Cyanophyta and Rotifera. The inlet channel of BB-IAT Karang Intan and the broodstock pond belong to mesotrophic category, predominance by Cyanophyta, Chlorophyta and Rotifer. BBIAT Karang Intan outlet ponds, BBAT Mandiangin inlet channel and Cindai Alus inlet pond are included in the oligotrophic category, predominance by Cyanophyta and Chlorophyta. Plankton community structure of the fishfarming pond varies even with the same ecological conditions.
Cooperation (Reciprocity) of Transmigration Community with Local Communities in Alur Village, Kecamatan Jorong, Kabupaten Tanah Laut
Authors: Purnomo Purnomo
Published: November 2019

The background of this research is the economic cooperation between the transmigration community and the local community, form of the economic cooperation, and factors driving and inhibiting the economic cooperation between transmigration community and the local community. The purpose of this research is to identify the economic cooperation, to describe the form of the economic cooperation, and to describe factors driving and inhibiting the formation of the economic cooperation between the transmigration community and the local community in Alur Village. This study used qualitative method and techniques of data collection are observation, interviews, and documentation. Through the qualitative approach, the researcher can perceive a social reality which is holistic or as a whole, complex, dynamic and full or meaning. Qualitative method in its use is to examine the condition of a natural object where the researcher works as the key instrument.The result showed that in fact the economy income of the transmigration community comes from agriculture (food crops), plantations (rubber) and corps (grain crops and vegetables) while the income of the local community comes from agriculture (food crop cultivation on dry land), and the nature availability around the village of Alur. The cooperation between the transmigration community and the local community associations in the forms of social gatherings and mutual helps.
Tourism Development Strategy of Mangrove Forest in the Village Langadai Kotabaru Hilir Subdistrict Kelumpang
Authors: Julianti Erni
Published: November 2019

The basic concept of tourism development strategy mangrove forest is reviewing the state of observation in the area of mangrove forests, perceptions and preferences of society and local government, and the use of SWOT analysis. This study aims to determine the development strategy of mangrove forest tour in the village Langadai Kelumpang Hilir Subdistrict, so mangrove well then expected to implement development programs and the development of an integrated strategy between the conservation of natural resouces with economic development in a sustainable society. The application of the concept of travel in the area of mangrove forest ecosystems in general is expected to reduce the rate of destruction of these areas by the public.  Processing method used is the analysis of the potensial landscape and strategy development SWOT analysis. Analysis of the data elements of the landscape each focal point of the model pengharkatan done that is by scoring according to the criteria assessment landscape elements that have been modified. While the SWOT analysis is a technique for identifying problems based on potential or strengths and weaknesses to address and respond to the opportunities and threats. So that the analysis results can be used as a basis for the development of mangrove forest tour in the village Langadai Kelumpang Hilir subdistrict in the future.  Based on the results of the assessment landscape mangrove forest tour in the village Langadai Kelumpang Hilir Subdistrict is in the range of 19-33 which means to have a high quality, so it has the potential to be developed as the natural attractions. Based on the results of this study resulted in several recommendations that include: Completing the supporting infrastructure of natural traveled activities such as: roads, bridges, gazebo, fishing, sanitary facilities, public toilets and others. Promotion to the public both in the region and outside the region. The government should  make the rules tight areas in the preservation of nature and fully supported by the community. Improving the quality of management of natural attractions integrated manner.
Prediction of anthocyanin concentrations during red wine fermentation: development of Fourier transform infrared spectroscopy partial least squares models
Authors: Miramont Clément , Jourdes Michael , Selberg Torben , Vilstrup Juhl Henrik , Nørgaard Lars , Teissedre Pierre-Louis
Published: November 2019

Aim: The aim of the present study was to use Fourier transform infrared (FT–IR) spectroscopy with chemometrics to develop partial least squares (PLS) models to predict the concentrations of various anthocyanins during red wine fermentation.Methods and results: Must and wine samples were collected during fermentation. To maximize diversity, 12 different fermentations, of two different vintages and two different varieties, were followed. The anthocyanin composition of the samples was characterized by using different methods described in the literature: the concentration of free anthocyanins was determined by bisulphite bleaching, the concentration of molecular anthocyanins was determined by high-performance liquid chromatography with ultraviolet–visible detection, and the ratio of monomeric anthocyanins to polymeric anthocyanins was determined using the Adams–Harbertson assay. Finally, the data were analysed statistically by PLS regression to quantify laboratory-determined anthocyanin from FT–IR spectra. The correlations obtained showed good results for a large percentage of parameters studied, with the determination coefficient (R2) for both calibration and cross-validation exceeding 0.8. The models for molecular anthocyanins appeared to overestimate their prediction, owing to intercorrelation with other parameters. Comparison of the data for each vintage indicated no apparent matrix effect per year, and data for other vintages should be compared to validate this hypothesis. The best models were those for monomeric or polymeric pigments and free anthocyanins.Conclusions: By using FT–IR spectroscopy coupled with chemometrics, it is possible to create predictive models to estimate concentrations of anthocyanins and changes in global anthocyanin parameters during winemaking.Significance and impact of the study: These results improve our understanding of anthocyanin prediction using FT–IR spectroscopy with chemometrics and pave the way for its use as a process control tool for the winemaker. They also highlight the propensity of chemometrics to overestimate certain predicted values when close parameters intercorrelate.
S1 Subunit of Spike Protein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus is an Important Determinant of Virulence in Piglets
Authors: Suzuki Tohru , Terada Yutaka , Enjuanes Luis , Ohashi Seiichi , Kamitani Wataru
Published: November 2019

Base on the sequence of S genes, which encode spike proteins, we previously identified three different types (North American, S INDEL and S large-DEL types) of porcine epidemic diarrhea virus (PEDV) that have re-emerged in Japan since 2013. Base on experimental infections with the North American and S large-DEL types, we also hypothesized that PEDV virulence may be linked to the S1 subunit of the S protein. To test this hypothesis, we have now assayed in gnotobiotic piglets various recombinant PEDVs generated by reverse genetics. Piglets inoculated with CV777 maintained in National Institute of Animal Health, along with piglets infected with a recombinant form of the same virus, developed subclinical to mild diarrhea. In contrast, severe watery diarrhea, dehydration, weight loss, astasia, and high mortality were observed in piglets inoculated with recombinant strains in which the S gene was partially or fully replaced with corresponding sequences from the highly virulent Japanese PEDV isolate OKN-1/JPN/2013. Indeed, symptoms resembled those in piglets inoculated with the OKN-1/JPN/2013, and were especially pronounced in younger piglets. Collectively, the data demonstrate that the S1 subunit of the S protein is an important determinant of PEDV virulence, and advance development of new vaccine candidate.
Anticoagulant Therapy as a Tool for the Prevention of Cognitive Impairment Associated with Atrial Fibrillation
Authors: Ostroumova O. D. , Kochetkov A. I. , Korchagina S. P. , Ostroumova T. M. , Chernyaeva M. S. , Kirichenko A. A.
Published: November 2019

Atrial fibrillation (AF) is one of the most common cardiac arrhythmias in clinical practice and important additional risk factor for the development of cognitive impairment (CI) and dementia as it has been shown in recent studies. According to the Diagnostic and statistical manual of mental disorders latest revision CI refers to a decrease of one or more higher cortical functions that provide the processes of perception, storage, transformation and transmission of information compared to the premorbid level. The main hypothesis that explains the relationship between AF and dementia is the assumption that in the presence of this arrhythmia a brain substance is damaged due to microembolism and cerebral microbleeding. The high clinical significance of AF as well as CI served as a background for the development by European experts several consensus documents concerning the problem of the relationships between these conditions. In addition, they emphasize the role of anticoagulant therapy as a preventing tool for the development of stroke, which can be a factor in the CI progression in patients with AF, with particular priority to direct oral anticoagulants (DOACs). In randomized clinical trials, meta-analyses and systematic reviews have been shown that the use of DOACs, as compared to vitamin K antagonists, is a more rational strategy for preventing stroke associated with AF. Among the DOAC class, rivaroxaban is worth noticing as a drug that has a favorable efficacy profile for primary and secondary stroke prevention. Rivaroxaban distinguishing characteristics are a once daily administration as well as a calendar package which is practically important for patients with CI.
Modern Principles of Treatment of Uncontrolled Hypertension
Authors: Podzolkov V. I. , Tarzimanova A. I , Georgadze Z. O.
Published: November 2019

Despite the current possibilities of using different classes of antihypertensive drugs that effectively reduce blood pressure and significantly improve the long-term prognosis of patients, the problem of uncontrolled arterial hypertension has not lost its importance and its solution in a particular clinical situation often remains very difficult. The term "uncontrolled arterial hypertension" can be used in all cases where arterial pressure has not been achieved. The true prevalence of uncontrolled arterial hypertension has not been established, and its study is hampered primarily by the fact that not all patients initially receive antihypertensive therapy that meets generally accepted standards. Currently, the tactics of management of patients with uncontrolled hypertension involves the use of combinations of antihypertensive drugs. Rational combinations, according to the new recommendations for the diagnosis and treatment of arterial hypertension in 2018, remain a combination of blockers of the renin-angiotensin-aldosterone system – angiotensin-converting enzyme inhibitors or receptor blockers to angiotensin with a calcium antagonist or diuretic, preferably in one tablet. With the ineffectiveness of dual therapy needs to be assigned to a third antihypertensive drug. Among the most modern antihypertensive drugs can be considered a triple fixed combination of lisinopril, amlodipine and indapamide. All the components included in the composition of the drug, has proved its high efficiency and safety. Uncontrolled arterial hypertension remains one of the most urgent problems of modern cardiology. Many aspects of it are far from unambiguously interpreted solutions and standards. Until the end, the mechanisms of the formation of uncontrolled course of hypertension remain unexplored, which, in turn, leads to a restriction of the use of drug and non-drug methods in the treatment of this pathology. Rational choice of antihypertensive therapy regimens can significantly improve the quality of treatment of this category of patients.
Adverse Reactions of the Cardiovascular System when Taking Nonsteroidal Anti-inflammatory Drugs and Ways to Reduce Them
Authors: Pyrikova N. V. , Antropova O. N. , Osipova I. V.
Published: November 2019

The most important issue of modern pharmacotherapy is not only efficacy, but also the safety of medicines. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is one of the main methods of treating acute and chronic pain in a wide range of diseases and pathological conditions. However, the prescription of this group of drugs requires consideration of the potential risks of complications, including from the side of the cardiovascular system. The purpose of the review was to assess the adverse reactions of the cardiovascular system when taking NSAIDs and approaches to their reduction. The article presents data on the mutual potential impact of cardiovascular diseases and musculoskeletal system, presents the results of large-scale studies of Russian and foreign authors and meta-analyzes of the NSAIDs effect on blood pressure profile, development of myocardial infarction, stroke and heart failure. The possible pathogenetic mechanisms of the side effects of NSAIDs are reviewed; the complexity of managing comorbid patients is demonstrated; it is shown that symptomatic treatment of pain and inflammatory syndrome should be carried out considering a personalized approach to the patient and rational choice of drugs.

Before the NSAIDs prescription, it is necessary to consider all cardiovascular risk factors with the determination of the total risk of cardiovascular complications. In patients with a very high cardiovascular risk, the use of any NSAIDs should be avoided; with high and moderate risk, the use of NSAIDs with the most favorable cardiovascular safety profile is possible. If the patient belongs to the category of low total coronary risk, the doctor can choose any NSAIDs.
Contribution of aroma compounds to the antioxidant properties of roasted white yam (Dioscorea rotundata)
Authors: Lasekan Ola , Teoh Li Shing
Published: November 2019

Background The aroma chemistry and the contribution of the aroma compounds to the anti-oxidative properties of roasted yam have yet to be characterized. The growing popularity of roasted yam in regions where they are being consumed calls for a concerted effort to elucidate their aroma chemistry as well as their anti-oxidative properties. Results The aroma compounds in roasted white yam (Dioscorea rotundata) were isolated and identified using static headspace-gas chromatography-mass spectrometry (SH-GC-MS) and gas chromatography-olfactometry (GC-O). In addition, the anti-oxidative activities of the most abundant volatile heterocyclic compounds (2 pyrroles, 4 furans and 3 pyrazines) were evaluated on their inhibitory effect towards the oxidation of hexanal for a period of 30 days. Twenty-nine aroma-active compounds with a flavour dilution (FD) factor range of 2-256 and an array of odor notes were obtained. Among them, the highest odor activities (FD ≥ 128) factors were determined for 2-acetyl furan and 2-acetylpyrrole. Other compounds with significant FD factors ≥ 32 were; 2-methylpyrazine, ethyl furfural, and 5-hydroxy methyl furfural. Conclusion Results of the anti-oxidative activity showed that the pyrroles exhibited the greatest antioxidant activity among all the tested heterocyclic compounds. This was followed by the furans and the pyrazines which had the least antioxidant activity.
Prevalence of modifiable cardiovascular risk factors in Yazd inner-city municipalities
Authors: Mirzaei Mohsen , Mirzaei Masoud , Sarsangi Ali Reza , Bagheri Nasser
Published: November 2019

Background:Cardiovascular disease (CVD) is the leading cause of death in the world. With effective intervention and control of cardiovascular risk factors, mortality rates may be reduced. The aim of this study was to investigate the prevalence of modifiable cardiovascular risk factors across five municipalities in Yazd city. Methods:10,000 residents of the Yazd greater area aged 20-69 years were selected using cluster random sampling method. Overall, 200 clusters were randomly selected based on the postcodes of residents who lived in the five municipalities of Yazd. Those who lived in Yazd annexed cities and rural areas were excluded. A valid questionnaire was completed and physical examination was done (94.9% response rate). Instances of self-reported diabetes mellitus, high blood cholesterol, tobacco smoking, and unhealthy diet were recorded. Blood pressure, height, and weight were measured and physical activity was classified by International Physical Activity Questionnaire (IPAQ). A chi-square test was used to analyze the differences in variables across municipalities by SPSS V. 16. Results:We analyzed 8749 participants’ data from Yazd city. The prevalence of diabetes mellitus, hypercholesterolemia, and hypertension in Yazd were 14.1, 16.7 and 18.6%, respectively. One in every four people consumed the recommended five servings of vegetables per day. Fish consumption was less than 5% at least once a week. An unhealthy diet (85.7%); inactivity (52.2%), hypertension (36.7%) and obesity (26.3%) were the most common cardiovascular risk factors. Only 2.1% of adults had no risk factors for CVD, and almost 75% of people had more than one risk factor. The prevalence of risk factors (excluding hypertension) - was significantly different across the municipalities. Residents of region three had the highest prevalence of all risk factors aside from inactivity and unhealthy diet. Conclusion: Unhealthy dietary habits and inactivity are the most common modifiable risk factors of CVD in Yazd city. Spatial variations of cardiovascular risk factors observed. This geographic health inequality requires more attention from policymakers to control CVD risk factors across different municipalities accordingly. Promoting healthy lifestyle is the top priority of health intervention program. It is recommended to increase the appropriate sports space and restrict access to tobacconist in high-risk areas.
Association of sleep quality during pregnancy with stress and depression: a prospective birth cohort study in China
Authors: Gao Ming , Hu Jiajin , Yang Liu , Ding Ning , Wei Xiaotong , Li Lin , Liu Lei , Ma Yanan , Wen Deliang
Published: November 2019

Background: The sleep quality of pregnant women in the third trimester is related to mental health. However, there is still a lack of large-scale cohort research exploring this relationship in the second trimester. Thus, we assessed the associations of sleep quality during the second trimester with antenatal stress and antenatal and postnatal depression. Methods: We examined 1152 pregnant women from a prospective cohort study in China to assess the associations of sleep quality in the second trimester with antenatal stress, antenatal depression, and postnatal depression. We used linear regression models and logistic regression models to examine the associations of sleep quality (Pittsburgh Sleep Quality Index [PSQI]) during pregnancy with perinatal stress (Pregnancy Pressure Scale [PPS]) and depression (Edinburgh Postnatal Depression Scale [EPDS]) status. We further assessed the relationship in groups divided according to maternal age. Results: PSQI scores were positively associated with antenatal PPS scores (β: 1.52, 95% confidence interval [CI]: 1.28, 1.76), antenatal EPDS scores (β: 0.68, 95% CI: 0.58, 0.78), and postpartum EPDS scores (β: 0.51, 95% CI: 0.38, 0.64). Poor sleep quality (PSQI scores ≥ 5) was associated with antenatal stress status (odds ratio [OR]: 2.60, 95% CI: 1.79, 3.77), antenatal depression status (OR: 3.42, 95% CI: 2.48, 4.72), and postpartum depression status (OR: 2.40, 95% CI: 1.58, 3.64) after adjusting maternal age, BMI, gestational age, smoking, educational level, annual household income and social support. The association of poor sleep quality (PSQI scores ≥ 5) in the second trimester with postnatal depression status was significant among women more than or equal to 30 years old (OR: 4.12, 95% CI: 2.18, 7.78) but not among women less than 30 years old after adjusting covariates above. Conclusion: Poor sleep quality in the second trimester among Chinese pregnant women is associated with stress and depression symptoms. Strategies to boost sleep quality should be considered during prenatal health care to improve women’s mental health status.