bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 3 from FANCJ Localization by Mismatch Repair Is Vital to Maintain Genomic Integrity after UV Irradiation
Authors: Guillemette Shawna , Branagan Amy , Peng Min , Dhruva Aashana , Schärer Orlando D. , Cantor Sharon B.
Published: March 2023

PDF file - 228K, Supplemental Figure 3. FANCJ localizes to UV induced LUDs predominantly in S-Phase and contributes to the UV induced checkpoint
Supplementary Figure 4 from Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S
Authors: Weng Hengyou , Huang Huilin , Dong Bowen , Zhao Panpan , Zhou Hui , Qu Lianghu
Published: March 2023

PDF file - 32KB, Effects of miRNA inhibitors of the miR-17-19b cluster on the expression of BIM-S.
Supplementary Figure 3 from Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S
Authors: Weng Hengyou , Huang Huilin , Dong Bowen , Zhao Panpan , Zhou Hui , Qu Lianghu
Published: March 2023

PDF file - 55KB, Response of miRNAs to drug treatment in multiple leukemia cell lines.
Supplementary Figure 2 from Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S
Authors: Weng Hengyou , Huang Huilin , Dong Bowen , Zhao Panpan , Zhou Hui , Qu Lianghu
Published: March 2023

PDF file - 56KB, Overexpression of BIM induces apoptosis in K562 cells.
Supplementary Figures 1 - 6 from Tumor Suppressor VHL Functions in the Control of Mitotic Fidelity
Authors: Hell Michael P. , Duda Maria , Weber Thomas C. , Moch Holger , Krek Wilhelm
Published: March 2023

PDF file - 515K, Supplemental Figure 1: Reintroduction of full-length pVHL rescues mitotic defects in Vhl-negative MREC cells. Supplemental Figure 2: Further characterization of kidney injury surgery. Supplemental Figure 3: Characterization of Vhl Knockout Status and proliferation and apoptosis rate in Kidneys. Supplemental Figure 4: Characterization of the spindle angle determination and discrimination of proximal and distal kidney tubules. Supplemental Figure 5: Scoring system of chromosome missegregation errors. Supplemental Figure 6: Assessment of proliferation and apoptotic response in kidneys 4 months post ischemic injury.
Supplementary Figure Legend from Tumor Suppressor VHL Functions in the Control of Mitotic Fidelity
Authors: Hell Michael P. , Duda Maria , Weber Thomas C. , Moch Holger , Krek Wilhelm
Published: March 2023

PDF file - 110K
Supplementary Figure 1 from Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S
Authors: Weng Hengyou , Huang Huilin , Dong Bowen , Zhao Panpan , Zhou Hui , Qu Lianghu
Published: March 2023

PDF file - 33KB, Oridonin induces BIM-S in multiple leukemia cell lines.
Supplementary Figures 1 - 5 from Vemurafenib Cooperates with HPV to Promote Initiation of Cutaneous Tumors
Authors: Holderfield Matthew , Lorenzana Edward , Weisburd Ben , Lomovasky Lisa , Boussemart Lise , Lacroix Ludovic , Tomasic Gorana , Favre Michel , Vagner Stephan , Robert Caroline , Ghoddusi Majid , Daniel Dylan , Pryer Nancy , McCormick Frank , Stuart Darrin
Published: March 2023

PDF file - 507K, Koilocyte-like cells observed in an HPV negative verrucous papilloma (S1); H&E and pERK staining of gastric epithelium from mice treated for 60 days with 60 mg/kg Vemurafenib (S2); pERK staining of Vemurafenib and vehicle treated cSCC (S3); Reduced hyperkeratosis and improved grooming of K14-HPV16 mice treated with PD0325901 (S4); cSCC tumor response after treatment with 3 mg/kg PD0325901 (S5).
Supplementary Figures 1 - 9 from High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development
Authors: Lin Dong , Wyatt Alexander W. , Xue Hui , Wang Yuwei , Dong Xin , Haegert Anne , Wu Rebecca , Brahmbhatt Sonal , Mo Fan , Jong Lina , Bell Robert H. , Anderson Shawn , Hurtado-Coll Antonio , Fazli Ladan , Sharma Manju , Beltran Himisha , Rubin Mark , Cox Michael , Gout Peter W. , Morris James , Goldenberg Larry , Volik Stanislav V. , Gleave Martin E. , Collins Colin C. , Wang Yuzhuo
Published: March 2023

PDF file - 1579K, Supplementary Figure 1: Histopathological similarity between tumor lines and matched patient tumors. Supplementary Figure 2: Growth curves, host plasma PSA levels and response to castration/Bicalutmide in the tumor lines. Supplementary Figure 3: Similarity of genome copy number between tumor lines and matched patient tumors. Supplementary Figure 4: Conservation of genome copy number after multiple generations of serial passaging. Supplementary Figure 5: Molecular characteristics of transplantable tumour lines. Supplementary Figure 6: Androgen withdrawal leads to the development of castrate-resistant lines. Supplementary Figure 7: Characterization of the neuroendocrine prostate cancer phenotype in LTL331R. Supplementary Figure 8: Evidence of adaptive response to castration in LTL331. Supplementary Figure 9: Genes potentially predisposing LTL331 to neuroendocrine transdifferentiation represent candidate molecular markers for risk stratification.
Supplementary Figure 4 from Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2
Authors: Lopez-Rivera Esther , Jayaraman Padmini , Parikh Falguni , Davies Michael A. , Ekmekcioglu Suhendan , Izadmehr Sudeh , Milton Denái R. , Chipuk Jerry E. , Grimm Elizabeth A. , Estrada Yeriel , Aguirre-Ghiso Julio , Sikora Andrew G.
Published: March 2023

PDF file - 67K, A375 cells were treated with L-NIL (300 μM and 1000 μM) or the NO scavenger PTIO (300 μM) for 24 hours prior to harvest and preparation of protein lysates. Western Blot analyses of AKT phosphorylation at serine 473 and total AKT demonstrated lack of downregulation of AKT phosphorylation under conditions which strongly reduce downstream mTOR pathway activation.
Supplementary Figure 1 from Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation
Authors: Lallet-Daher Hélène , Wiel Clotilde , Gitenay Delphine , Navaratnam Naveenan , Augert Arnaud , Le Calvé Benjamin , Verbeke Stéphanie , Carling David , Aubert Sébastien , Vindrieux David , Bernard David
Published: March 2023

PDF - 2893KB, Screening and cellular model of oncogenic stress induce senescence hallmarks.
Supplementary Figure 2 from NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells
Authors: Kottakis Filippos , Foltopoulou Parthena , Sanidas Ioannis , Keller Patricia , Wronski Ania , Dake Benjamin T. , Ezell Scott A. , Shen Zhu , Naber Stephen P. , Hinds Philip W. , McNiel Elizabeth , Kuperwasser Charlotte , Tsichlis Philip N.
Published: March 2023

PDF file - 867KB, NDY1/KDM2B is required for cellular transformation by RAS-G12V.
Supplementary Table S1 from HMGB1 Enhances Immune Suppression by Facilitating the Differentiation and Suppressive Activity of Myeloid-Derived Suppressor Cells
Authors: Parker Katherine H. , Sinha Pratima , Horn Lucas A. , Clements Virginia K. , Yang Huan , Li Jianhua , Tracey Kevin J. , Ostrand-Rosenberg Suzanne
Published: March 2023

Supplementary Table S1. Quantitation of HMGB1 secreted by cultured tumor cells, ex vivo macrophages and MDSC, in vivo grown tumors, and cultures of MDSC differentiated from bone marrow progenitor cells.
Supplementary Figure 5 from Activation of the NOTCH Pathway in Head and Neck Cancer
Authors: Sun Wenyue , Gaykalova Daria A. , Ochs Michael F. , Mambo Elizabeth , Arnaoutakis Demetri , Liu Yan , Loyo Myriam , Agrawal Nishant , Howard Jason , Li Ryan , Ahn Sun , Fertig Elana , Sidransky David , Houghton Jeffery , Buddavarapu Kalyan , Sanford Tiffany , Choudhary Ashish , Darden Will , Adai Alex , Latham Gary , Bishop Justin , Sharma Rajni , Westra William H. , Hennessey Patrick , Chung Christine H. , Califano Joseph A.
Published: March 2023

PDF file - 68K, Growth effects of HEY1 siRNA inhibition in HNSCC cells with wildtype NOTCH1 status. HEY1 was downregulated in UPCI-SCC090 and SCC61 by siRNA as described in methods. The effect of siHEY1 on the expression of HEY1 is shown on the left. The effect of HEY1 downregulation on cell proliferation for these two cell lines is shown on the right. Note, there is over 90% transfection efficiency of HEY1 downregulation for each cell line, however the strong growth inhibition effect was shown only for NOTCH1 wildtype 090 cell line.
Supplementary Figure 7 from HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2
Authors: Cheng Guangcun , Sun Xueqing , Wang Jinglong , Xiao Gang , Wang Xiumin , Fan Xuemei , Zu Lidong , Hao Mingang , Qu Qing , Mao Yan , Xue Yunjing , Wang Jianhua
Published: March 2023

PDF file - 132K, LCN2 does not affect PTEN activity.
Supplementary Figure 6 from HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2
Authors: Cheng Guangcun , Sun Xueqing , Wang Jinglong , Xiao Gang , Wang Xiumin , Fan Xuemei , Zu Lidong , Hao Mingang , Qu Qing , Mao Yan , Xue Yunjing , Wang Jianhua
Published: March 2023

PDF file - 142K, The AKT signaling pathway is partly inactivated after NGALR knockdown.
Video S4 from The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development
Authors: Venkateswaran Amudhan , Sekhar Konjeti R. , Levic Daniel S. , Melville David B. , Clark Travis A. , Rybski Witold M. , Walsh Alexandra J. , Skala Melissa C. , Crooks Peter A. , Knapik Ela W. , Freeman Michael L.
Published: March 2023

AVI file 79712K, circulation in embryo treated with VJ11
Supplementary Figure 2 from HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2
Authors: Cheng Guangcun , Sun Xueqing , Wang Jinglong , Xiao Gang , Wang Xiumin , Fan Xuemei , Zu Lidong , Hao Mingang , Qu Qing , Mao Yan , Xue Yunjing , Wang Jianhua
Published: March 2023

PDF file - 131K, LCN2 does not affect ERK and NF-kB pathways.
Fig S3 from The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development
Authors: Venkateswaran Amudhan , Sekhar Konjeti R. , Levic Daniel S. , Melville David B. , Clark Travis A. , Rybski Witold M. , Walsh Alexandra J. , Skala Melissa C. , Crooks Peter A. , Knapik Ela W. , Freeman Michael L.
Published: March 2023

PDF file 3827K, Characterization of Enox1 morphants
Dataset S4 from The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development
Authors: Venkateswaran Amudhan , Sekhar Konjeti R. , Levic Daniel S. , Melville David B. , Clark Travis A. , Rybski Witold M. , Walsh Alexandra J. , Skala Melissa C. , Crooks Peter A. , Knapik Ela W. , Freeman Michael L.
Published: March 2023

XLSX file 11K, Expression of transcription factors and membrane receptors critical for vascular development
Data Supplement from Osteopontin Shapes Immunosuppression in the Metastatic Niche
Authors: Sangaletti Sabina , Tripodo Claudio , Sandri Sara , Torselli Ilaria , Vitali Caterina , Ratti Chiara , Botti Laura , Burocchi Alessia , Porcasi Rossana , Tomirotti Andrea , Colombo Mario P. , Chiodoni Claudia
Published: March 2023

Supplemental Methods.
Data Supplement from Osteopontin Shapes Immunosuppression in the Metastatic Niche
Authors: Sangaletti Sabina , Tripodo Claudio , Sandri Sara , Torselli Ilaria , Vitali Caterina , Ratti Chiara , Botti Laura , Burocchi Alessia , Porcasi Rossana , Tomirotti Andrea , Colombo Mario P. , Chiodoni Claudia
Published: March 2023

Supplemental Table 1. Clinical parameters of human breast cancer cases.
Supplementary Figure and Table Legends from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Authors: Kim Jae-Hwan , Sharma Amrish , Dhar Shilpa S. , Lee Sung-Hun , Gu Bingnan , Chan Chia-Hsin , Lin Hui-Kuan , Lee Min Gyu
Published: March 2023

PDF file - 102KB
Supplementary Figure 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells
Authors: Kim Jae-Hwan , Sharma Amrish , Dhar Shilpa S. , Lee Sung-Hun , Gu Bingnan , Chan Chia-Hsin , Lin Hui-Kuan , Lee Min Gyu
Published: March 2023

PDF file - 155KB, UTX knockdown had no effect on cell migration, whereas MLL4 depletion moderately decreased cell migration.
Supplementary Table 2 from Identification of a Cyclin D1 Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint
Authors: Ju Xiaoming , Casimiro Mathew C. , Gormley Michael , Meng Hui , Jiao Xuanmao , Katiyar Sanjay , Crosariol Marco , Chen Ke , Wang Min , Quong Andrew A. , Lisanti Michael P. , Ertel Adam , Pestell Richard G.
Published: March 2023

XLSX file - 118K, Functional annotation clustering of cyclin D1 induced genes.
Supplementary Figure 5 from Identification of a Cyclin D1 Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint
Authors: Ju Xiaoming , Casimiro Mathew C. , Gormley Michael , Meng Hui , Jiao Xuanmao , Katiyar Sanjay , Crosariol Marco , Chen Ke , Wang Min , Quong Andrew A. , Lisanti Michael P. , Ertel Adam , Pestell Richard G.
Published: March 2023

PDF file - 131K, Endogenous cyclin D1 maintains prostate cancer stem cell population.
Supplementary Figure 3 from YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway
Authors: Zhao Yulei , Khanal Prem , Savage Paul , She Yi-Min , Cyr Terry D. , Yang Xiaolong
Published: March 2023

PDF file - 2248KB, Cdk1 phosphorylation of YAP is essential for Taxol-induced disruption of YAP-TEAD interaction.
Supplementary Figure 5 from NUP98 Fusion Oncoproteins Promote Aneuploidy by Attenuating the Mitotic Spindle Checkpoint
Authors: Salsi Valentina , Ferrari Silvia , Gorello Paolo , Fantini Sebastian , Chiavolelli Francesca , Mecucci Cristina , Zappavigna Vincenzo
Published: March 2023

PDF - K, Supplementary Figure 5. Interference of NUP98-fusions with APC/C activity involves primarily CDC20. HEK293 cells were transfected with a control siRNA or with siRNAs against the indicated proteins (CDC20 or CDH1), together with the expression constructs for NUP98 or NUP98-fusion proteins (indicated on the left). Immunoblot analysis shows Securin (SEC) or CyclinB1 (CCNB1) levels after Nocodazole treatment for the indicated time points. Anti-betaactin (betaACT) was used as a loading control.
Supplemental Tables S1-S2 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: March 2023

IHC scores of ADAR1 in 136 matched pairs of primary ESCCs and (NT) tissues (S1); The positive correlation between the tumoral overexpression of ADAR1 and tumoral genomic amplification of ADAR1 (S2).
Supplementary Movie 4 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: March 2023

MP4 file - 1786K, Supplementary movie S4: time-lapse video-microscopy with a 10x magnification objective, of Lu1205 cells plated on plastic 48 hr after ICAT transfection.
Supplementary Figure 5 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: March 2023

PDF file - 147K, Exogenous ICAT expression does not affect the morphology of Mel501 and Skmel3 cells.
Supplementary Figures 1 - 3 from Immunosurveillance by Antiangiogenesis: Tumor Growth Arrest by T Cell–Derived Thrombospondin-1
Authors: Schadler Keri L. , Crosby Erika J. , Zhou Alice Yao , Bhang Dong Ha , Braunstein Lior , Baek Kwan Hyuck , Crawford Danielle , Crawford Alison , Angelosanto Jill , Wherry E. John , Ryeom Sandra
Published: March 2023

PDF file - 706K, Supplemental Figure 1- TSP-1 suppresses tumor growth and is cleaved after immune activation. Supplemental Figure 2 - LCMVa infection inhibits B16F10 melanoma growth long term and does not change the number of macrophages or neutrophils in the tumor. Supplemetal Figure 3- Tumor suppression is T cell dependent.
Supplementary Figure Legends from Distinct Functions of Epidermal and Myeloid-Derived VEGF-A in Skin Tumorigenesis Mediated by HPV8
Authors: Ding Xiaolei , Lucas Tina , Marcuzzi Gian P. , Pfister Herbert , Eming Sabine A.
Published: March 2023

Supplementary Figure Legends. Legends for Supplementary Figures S1-S3.
Data Supplement from Loss of NF1 in Cutaneous Melanoma Is Associated with RAS Activation and MEK Dependence
Authors: Nissan Moriah H. , Pratilas Christine A. , Jones Alexis M. , Ramirez Ricardo , Won Helen , Liu Cailian , Tiwari Shakuntala , Kong Li , Hanrahan Aphrothiti J. , Yao Zhan , Merghoub Taha , Ribas Antoni , Chapman Paul B. , Yaeger Rona , Taylor Barry S. , Schultz Nikolaus , Berger Michael F. , Rosen Neal , Solit David B.
Published: March 2023

Supplementary Figures S1-S8. Levels of RAS-GTP in melanoma cell lines (S1); Changes in pERK and cyclin D1 levels as function of time in cells treated with the MEK inhibitor PD0325901 (S2); Sk-Mel-113 (NF1 null) melanoma cells are resistant to AKT inhibition (S3); Variability in induction of pMEK levels following exposure to four allosteric MEK inhibitors (S4); Exon-capture deep sequencing via IMPACT of the NF1 gene in M308 shows a nonsense Q1070* mutation (S5); Expression of activated RAS is sufficient to confer resistance to vemurafenib in Sk-Mel-239 (BRAF V600E) cells (S6); Sensitivity of A375 (BRAF V600E) cells to vemurafenib (S7); The MAPK pathway and the inhibitors used in the study of NF1-null cells (S8).
Supplementary FIgure S2 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: March 2023

Figure. S2. Treatment with MDV3100 could inhibit RCC cells migration, invasion and proliferation.
Supplementary Figure Legends from IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Authors: Ma Shoubao , Cheng Qiao , Cai Yifeng , Gong Huanle , Wu Yan , Yu Xiao , Shi Liyun , Wu Depei , Dong Chen , Liu Haiyan
Published: March 2023

PDF file - 136KB
Supplementary Figure 3 from Dramatic Antitumor Effects of the Dual MET/RON Small-Molecule Inhibitor LY2801653 in Non–Small Cell Lung Cancer
Authors: Kawada Ichiro , Hasina Rifat , Arif Qudsia , Mueller Jeffrey , Smithberger Erin , Husain Aliya N. , Vokes Everett E. , Salgia Ravi
Published: March 2023

PDF file - 94K, Figure S3. Analysis of immunohistochemistry staining and evaluation. A. Scoring system is shown. A pathologist coded MET, p-MET, RON, and p-RON expression as the percentage of positive tumor cells (scale 0%-100%) with staining intensity from 0 to 3+. Positive IHC expression is defined as Scoring System. B. Phosphorylated MET was decreased modestly in LY2801653-treated mice in both A549 and H1993 studies. Moreover, in the treated arms of H1993, Phosphorylated RON was slightly decreased in LY2801653-treated mice.
Supplementary Figure 2 from Dramatic Antitumor Effects of the Dual MET/RON Small-Molecule Inhibitor LY2801653 in Non–Small Cell Lung Cancer
Authors: Kawada Ichiro , Hasina Rifat , Arif Qudsia , Mueller Jeffrey , Smithberger Erin , Husain Aliya N. , Vokes Everett E. , Salgia Ravi
Published: March 2023

PDF file - 124K, Figure S2. Sub-network 'Calmodulin, c-Cbl, MET, PI3K reg class IA (p85), PDGF-R-beta' of Mitogenic signaling (Supplementary Table S1 No.1). Sub-network is made using 'Analyze network, Build Network' of GeneGo from the significant gene lists associated with H1993 treatment with LY2801653 (3 nM). STAT3 serves as both the divergence and convergence hub. Underexpressed genes (highlighted as blue targets) are significant genes from PamGene data. Eight out of 9 blue targets are represented. CD3Z was excluded from the network to simplify visualization because CD3Z is not related to NSCLC directly. The network objects to be placed in specific sectors of the network according to their sub-cellular localization. The localization sectors are Nucleus, Cytoplasm, Membrane, and Extracellular. Arrow between nodes describes positive (green), negative (red), and unspecified (black) interactions.
Supplementary Figure 1 from Dramatic Antitumor Effects of the Dual MET/RON Small-Molecule Inhibitor LY2801653 in Non–Small Cell Lung Cancer
Authors: Kawada Ichiro , Hasina Rifat , Arif Qudsia , Mueller Jeffrey , Smithberger Erin , Husain Aliya N. , Vokes Everett E. , Salgia Ravi
Published: March 2023

PDF file - 62K, Figure S1. The protein tyrosine kinase activity profile obtained by using H1993 lysates treated with LY2801653 (10 nM) as tested on PamChip microarrays. For each of the 144 protein tyrosine kinase peptides on the array, treatment response was calculated as the log-transformed ratio of phosphorylation. 47 significant tyrosine kinase substrate modulation by LY2801653 (10 nM) treatment is shown (*: p-value <0.05, paired-two-tailed Student's t test).
Supplementary Figure 7 from IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Authors: Ma Shoubao , Cheng Qiao , Cai Yifeng , Gong Huanle , Wu Yan , Yu Xiao , Shi Liyun , Wu Depei , Dong Chen , Liu Haiyan
Published: March 2023

PDF file - 99KB, Depletion of MDSCs by gemcitabine treatment reduces tumor growth.
Supplementary Figure 6 from IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Authors: Ma Shoubao , Cheng Qiao , Cai Yifeng , Gong Huanle , Wu Yan , Yu Xiao , Shi Liyun , Wu Depei , Dong Chen , Liu Haiyan
Published: March 2023

PDF file - 112KB, IL-17R is mainly expressed on myeloid derived cells in tumor microenvironment.
Supplementary Tables 1, 2, 4, 6, 9 - 12 from Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair
Authors: Halvey Patrick J. , Wang Xiaojing , Wang Jing , Bhat Ajaz A. , Dhawan Punita , Li Ming , Zhang Bing , Liebler Daniel C. , Slebos Robbert J.C.
Published: March 2023

PDF file - 121K, Table S1. Genetic features of cell lines. Table S2. Summary of standard search results. Table S4. Summary of customized search results. Table S6. SelTarBase gene list. Table S9. Parameters for MRM analyses. Table S10. Detailed co-expression module results. Table S11. Observed variant peptides Table S12. Mapping of co-expression cluster results.
Supplementary Figure 5 from IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Authors: Ma Shoubao , Cheng Qiao , Cai Yifeng , Gong Huanle , Wu Yan , Yu Xiao , Shi Liyun , Wu Depei , Dong Chen , Liu Haiyan
Published: March 2023

PDF file - 89KB, IL-17A does not directly affect CD8+ T cells proliferation and cytokine production in vitro.
Supplementary Figure 4 from IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
Authors: Ma Shoubao , Cheng Qiao , Cai Yifeng , Gong Huanle , Wu Yan , Yu Xiao , Shi Liyun , Wu Depei , Dong Chen , Liu Haiyan
Published: March 2023

PDF file - 119KB, The effect of in vivo Vgamma4 gammadelta T cell depletion and the purity of in vitro expanded Vgamma4 gammadelta T cells.
Supplementary Table 5 from Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair
Authors: Halvey Patrick J. , Wang Xiaojing , Wang Jing , Bhat Ajaz A. , Dhawan Punita , Li Ming , Zhang Bing , Liebler Daniel C. , Slebos Robbert J.C.
Published: March 2023

PDF file - 945K, Customized search spectral table.
Supplementary Figures 1 - 2 from Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair
Authors: Halvey Patrick J. , Wang Xiaojing , Wang Jing , Bhat Ajaz A. , Dhawan Punita , Li Ming , Zhang Bing , Liebler Daniel C. , Slebos Robbert J.C.
Published: March 2023

PDF file - 909K, Figure 1A. Spectra obtained from the customized dataset (Observed) and from a synthetic GPATCH4 peptide (Synthetic ) Figure 1B. Spectra obtained from the customized dataset (Observed) and from a synthetic CCT8 peptide (Synthetic ) Figure 1C. Spectra obtained from the customized dataset (Observed) and from a synthetic ANXA11 peptide (Synthetic ) Figure 1D. Spectra obtained from the customized dataset (Observed) and from a synthetic SRSF9 peptide (Synthetic ) Figure 1E. Spectra obtained from the customized dataset (Observed) and from a synthetic CEACAM1 peptide (Synthetic ) Figure 1F. Spectra obtained from the customized dataset (Observed) and from a synthetic EBP41L1 peptide (Synthetic ) Figure S2. Comparison of spectral count results with MRM results for selected proteins. Panel A, HSP90AB1; Panel B, HSP90AA1; Panel C, BAG3; Panel D, TNOP1; Panel E, FECH; Panel F, TTC19; Panel G, CAND1; Panel H, CARM1; Panel I, NARS ; Panel J, PAICS; Panel K, PFAS; Panel L, EEF2; Panel M, CPD; Panel N, DSTN; Panel O, ESRP1; Panel P, ERAP1, Panel Q, KRT8; Panel R, KRT18; Panel S, KRT19; and Panel T, CDH1.
Supplementary Table 4 from The Niacin/Butyrate Receptor GPR109A Suppresses Mammary Tumorigenesis by Inhibiting Cell Survival
Authors: Elangovan Selvakumar , Pathania Rajneesh , Ramachandran Sabarish , Ananth Sudha , Padia Ravi N. , Lan Ling , Singh Nagendra , Martin Pamela M. , Hawthorn Lesleyann , Prasad Puttur D. , Ganapathy Vadivel , Thangaraju Muthusamy
Published: March 2023

XLSX file - 43K, Supplementary Table 4 contains the top 100 down regulated genes that are differentially expressed in MB231-pCDH and MB231-GPR109A stable clones in the presence and absence of niacin.
Supplementary Table 1 from A Sequence Polymorphism in miR-608 Predicts Recurrence after Radiotherapy for Nasopharyngeal Carcinoma
Authors: Zheng Jian , Deng Jieqiong , Xiao Mang , Yang Lei , Zhang Liyuan , You Yonghe , Hu Min , Li Na , Wu Hongchun , Li Wei , Lu Jiachun , Zhou Yifeng
Published: March 2023

PDF file - 70K, All SNPs located in the mature miRNA sequence.
Supplementary Table 3 from The Niacin/Butyrate Receptor GPR109A Suppresses Mammary Tumorigenesis by Inhibiting Cell Survival
Authors: Elangovan Selvakumar , Pathania Rajneesh , Ramachandran Sabarish , Ananth Sudha , Padia Ravi N. , Lan Ling , Singh Nagendra , Martin Pamela M. , Hawthorn Lesleyann , Prasad Puttur D. , Ganapathy Vadivel , Thangaraju Muthusamy
Published: March 2023

XLSX file - 42K, Supplementary Table 3 contains the top 100 upregulated genes that are differentially expressed in MB231-pCDH and MB231-GPR109A stable clones in the presence and absence of niacin.
Supplementary Figure Legends from Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
Authors: Nagathihalli Nagaraj S. , Beesetty Yugandhar , Lee Wooin , Washington M. Kay , Chen Xi , Lockhart A. Craig , Merchant Nipun B.
Published: March 2023

PDF file - 81KB
Supplementary Figure 1 from Overexpression of the Transcription Factor MEF2D in Hepatocellular Carcinoma Sustains Malignant Character by Suppressing G2–M Transition Genes
Authors: Ma Leina , Liu Jia , Liu Limei , Duan Guangjie , Wang Qingliang , Xu Yanmin , Xia Feng , Shan Juanjuan , Shen Junjie , Yang Zhi , Bie Ping , Cui Youhong , Bian Xiu-Wu , Prieto Jesus , Avila Matías A. , Qian Cheng
Published: March 2023

PDF file - 195K, Supplementary Figures S1: Expression of MEF2D and miR-122 in HCC cell lines and patient-derived primary HCC cultures of tumor cells.
Supplementary Figure S4 from 5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell–like Cells in Acute Myeloid Leukemia
Authors: Roos Jessica , Oancea Claudia , Heinssmann Maria , Khan Dilawar , Held Hannelore , Kahnt Astrid S. , Capelo Ricardo , la Buscató Estel , Proschak Ewgenij , Puccetti Elena , Steinhilber Dieter , Fleming Ingrid , Maier Thorsten J. , Ruthardt Martin
Published: March 2023

Effect of CJ-13,610 on Wnt-target genes in the PML/RARα-positive cell line NB4.
Supplementary Figure 2 from Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
Authors: Nagathihalli Nagaraj S. , Beesetty Yugandhar , Lee Wooin , Washington M. Kay , Chen Xi , Lockhart A. Craig , Merchant Nipun B.
Published: March 2023

PDF file - 106KB, AREG and TGF-alpha shedding in CRC and PDAC cells.
Supplementary Figure S3 from 5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell–like Cells in Acute Myeloid Leukemia
Authors: Roos Jessica , Oancea Claudia , Heinssmann Maria , Khan Dilawar , Held Hannelore , Kahnt Astrid S. , Capelo Ricardo , la Buscató Estel , Proschak Ewgenij , Puccetti Elena , Steinhilber Dieter , Fleming Ingrid , Maier Thorsten J. , Ruthardt Martin
Published: March 2023

Effect of Zileuton on stem cell capacity in PML/RARα positive HSPCs.
Supplementary Figure S1 from 5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell–like Cells in Acute Myeloid Leukemia
Authors: Roos Jessica , Oancea Claudia , Heinssmann Maria , Khan Dilawar , Held Hannelore , Kahnt Astrid S. , Capelo Ricardo , la Buscató Estel , Proschak Ewgenij , Puccetti Elena , Steinhilber Dieter , Fleming Ingrid , Maier Thorsten J. , Ruthardt Martin
Published: March 2023

Pharmaceutical inhibition of all three major arachidonic acid pathways and its effect on replating efficiency of PML/RARα-expressing murine HSPCs.
Supplementary Figure Legends from 5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell–like Cells in Acute Myeloid Leukemia
Authors: Roos Jessica , Oancea Claudia , Heinssmann Maria , Khan Dilawar , Held Hannelore , Kahnt Astrid S. , Capelo Ricardo , la Buscató Estel , Proschak Ewgenij , Puccetti Elena , Steinhilber Dieter , Fleming Ingrid , Maier Thorsten J. , Ruthardt Martin
Published: March 2023

Supplementary Figure Legends
Supplementary Methods from The CXCL7/CXCR1/2 Axis Is a Key Driver in the Growth of Clear Cell Renal Cell Carcinoma
Authors: Grépin Renaud , Guyot Mélanie , Giuliano Sandy , Boncompagni Marina , Ambrosetti Damien , Chamorey Emmanuel , Scoazec Jean-Yves , Negrier Sylvie , Simonnet Hélène , Pagès Gilles
Published: March 2023

PDF file - 73K
Supplementary Table 3 from Glioblastoma Cell Enrichment Is Critical for Analysis of Phosphorylated Drug Targets and Proteomic–Genomic Correlations
Authors: Mueller Claudius , deCarvalho Ana C. , Mikkelsen Tom , Lehman Norman L. , Calvert Valerie , Espina Virginia , Liotta Lance A. , Petricoin Emanuel F.
Published: March 2023

XLSX file - 23K, Spearman's Rho correlation of (phospho)protein levels between LCM and non-LCM samples.
Supplementary Materials and Methods, Figure Legends from Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis
Authors: Kim Seaho , Yao Jiahong , Suyama Kimita , Qian Xia , Qian Bin-Zhi , Bandyopadhyay Sanmay , Loudig Olivier , De Leon-Rodriguez Carlos , Zhou Zhen Ni , Segall Jeffrey , Macian Fernando , Norton Larry , Hazan Rachel B.
Published: March 2023

PDF file - 98KB
Supplementary Figure 2 from Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
Authors: Gomez German G. , Volinia Stefano , Croce Carlo M. , Zanca Ciro , Li Ming , Emnett Ryan , Gutmann David H. , Brennan Cameron W. , Furnari Frank B. , Cavenee Webster K.
Published: March 2023

PDF file - 99KB, Mesenchymal GBMs show an overall decrease in miR-9 expression.
Supplementary Figure 1 from Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay
Authors: MacArthur Kelly M. , Kao Gary D. , Chandrasekaran Sanjay , Alonso-Basanta Michelle , Chapman Christina , Lustig Robert A. , Wileyto E. Paul , Hahn Stephen M. , Dorsey Jay F.
Published: March 2023

PDF file - 103KB, Supplementary Figure 1. Lack of effect of probe on control blood from healthy volunteers.
Supplementary Figure S5 from ERBB3-Independent Activation of the PI3K Pathway in EGFR-Mutant Lung Adenocarcinomas
Authors: Song Xiaoling , Fan Pang-Dian , Bantikassegn Amlak , Guha Udayan , Threadgill David W. , Varmus Harold , Politi Katerina
Published: March 2023

Supplementary Figure S5. ERBB3 knockdown partially affects the viability of EGFR mutant lung cancer cell lines.
Supplementary Table 3 from The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation
Authors: Raha Debasish , Wilson Timothy R. , Peng Jing , Peterson David , Yue Peng , Evangelista Marie , Wilson Catherine , Merchant Mark , Settleman Jeff
Published: March 2023

XLSX file - 41KB, IC50 values for kinase inhibitors used in the study.
Supplemental Figure and Movie Legend from Novel Paracrine Modulation of Notch–DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas
Authors: Nandhu Mohan S. , Hu Bin , Cole Susan E. , Erdreich-Epstein Anat , Rodriguez-Gil Diego J. , Viapiano Mariano S.
Published: March 2023

Legends for Supplemental Figures S1-S5 and Supplemental Movie S1.
Supplementary Figure 4 from Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Authors: Ostenfeld Marie Stampe , Jeppesen Dennis K. , Laurberg Jens R. , Boysen Anders T. , Bramsen Jesper B. , Primdal-Bengtson Bjarke , Hendrix An , Lamy Philippe , Dagnaes-Hansen Frederik , Rasmussen Mads H. , Bui Khan H. , Fristrup Niels , Christensen Erik I. , Nordentoft Iver , Morth Jens P. , Jensen Jørgen B. , Pedersen Jakob S. , Beck Martin , Theodorescu Dan , Borre Michael , Howard Kenneth A. , Dyrskjøt Lars , Ørntoft Torben Falck
Published: March 2023

Effect of RAB27A, RAB27B, and NSMASE2 inhibition on cellular migration and invasion. Bioinformatic analysis of mRNA target sites, AGO2 immunoprecipitation. Analysis of genomic alterations in the miR23b locus and correlation between expression and methylation of selected miRNAs (TCGA dataset).
Supplementary Figure S2 from Sentinel Lymph Node Biopsy Revisited: Ultrasound-Guided Photoacoustic Detection of Micrometastases Using Molecularly Targeted Plasmonic Nanosensors
Authors: Luke Geoffrey P. , Myers Jeffrey N. , Emelianov Stanislav Y. , Sokolov Konstantin V.
Published: March 2023

MAPS allow differentiation of delivery and molecular interactions.
Supplementary Figure S3 from BET Protein Inhibitor JQ1 Attenuates Myc-Amplified MCC Tumor Growth In Vivo
Authors: Shao Qiang , Kannan Aarthi , Lin Zhenyu , Stack Brendan C. , Suen James Y. , Gao Ling
Published: March 2023

Supplementary Figure S3. JQ1 exerts no effect on mTOR pathway and MCC cells express characteristic MCC makers, including a Merkel cell specific transcription factor Math1.
Supplemental Figure S6 from Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer
Authors: Tran Hung D. , Luitel Krishna , Kim Michael , Zhang Kun , Longmore Gregory D. , Tran David D.
Published: March 2023

Supplemental Figure S6. Related to Figure 5D: SNAIL1 is not expressed by lung metastases in mice overexpressing SNAIL1 in primary breast tumors
Figure S4. The combination of BSO and rapamycin induces mitochondrial ROS and alters mitochondrial morphology from mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress
Authors: Li Jing , Shin Sejeong , Sun Yang , Yoon Sang-Oh , Li Chenggang , Zhang Erik , Yu Jane , Zhang Jianming , Blenis John
Published: March 2023

mitochondrial ROS levels measurement in Tsc2-/- MEFs and WT MEFs treated with indicated compounds
Supplementary Figures 1 - 7, Table 1 from EGFR Blockade Enriches for Lung Cancer Stem–like Cells through Notch3-Dependent Signaling
Authors: Arasada Rajeswara Rao , Amann Joseph M. , Rahman Mohammad A. , Huppert Stacey S. , Carbone David P.
Published: March 2023

Supplementary Figure 1. ALDH assay time course in HCC827 cells and gating based on DEAB and DMSO controls. Supplementary Figure 2. Erlotinib treatment of H1650, EGFR mutant lung cancer cells but resistant to erlotinib. Supplementary Figure 3. Erlotinib treatment of EGFR wild type lung cancer cells increases the fraction of ALDH+ cells. Supplementary Figure 4. Related to Figure 3. EGFR mediated negative regulation of Notch3 transcriptional activity in a tyrosine kinase-dependent manner. Supplementary Figure 5 Validation of Notch1 and 3 expression upon transfection with siRNAs. Supplementary Figure 6. Validation of EGF-mediated association between EGFR and Notch 3 receptors in HCC2429 cells. Supplementary Figure 7. EGFR kinase activity is necessary for the tyrosine phosphorylation of the Notch3 receptor. Supplementary Table 1. Treatment with erlotinib increases ALDH+ cells in HCC827 cells.
Supplementary Figure 1 from A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Authors: Fujimura Ken , Wright Tracy , Strnadel Jan , Kaushal Sharmeela , Metildi Cristina , Lowy Andrew M. , Bouvet Michael , Kelber Jonathan A. , Klemke Richard L.
Published: March 2023

Contains additional biochemical and immunohistochemical data.
Supplementary Methods from Distinct Subpopulations of Head and Neck Cancer Cells with Different Levels of Intracellular Reactive Oxygen Species Exhibit Diverse Stemness, Proliferation, and Chemosensitivity
Authors: Chang Ching-Wen , Chen Yu-Syuan , Chou Shiu-Huey , Han Chia-Li , Chen Yu-Ju , Yang Cheng-Chieh , Huang Chih-Yang , Lo Jeng-Fan
Published: March 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: March 2023

Supplementary Figure S6. Validating immunodepletion of NK cells and basophils in RAG1-/- mice.
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Authors: von Roemeling Christina A. , Radisky Derek C. , Marlow Laura A. , Cooper Simon J. , Grebe Stefan K. , Anastasiadis Panagiotis Z. , Tun Han W. , Copland John A.
Published: March 2023

Supplementary Figure 3. (A) QPCR for GluR4 mRNA in A498 cells infected with one of four lentiviral constructs against GluR4 (sh925, sh1676, sh2145, sh2285) as compared to NT control. (B) Western blot analysis for GluR4 expression in all four A498 GluR4 shRNA clones compared to NT control. Protein expression level quantitation is normalized to β-actin. (C) Proliferation of A498 GluR4 shRNA clones compared to NT control.
Figure S7 from Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Authors: Tao Shasha , Wang Shue , Moghaddam Seyed Javad , Ooi Aikseng , Chapman Eli , Wong Pak K. , Zhang Donna D.
Published: March 2023

Figure S7. The average number of lesions (AHH+adenomas vs. adenocarcinomas).
Figure S5 from Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Authors: Tao Shasha , Wang Shue , Moghaddam Seyed Javad , Ooi Aikseng , Chapman Eli , Wong Pak K. , Zhang Donna D.
Published: March 2023

Figure S5. Larger images of the IHC analysis shown in Figure 5D, left panel.
Supplementary Figure Legends from Paclitaxel Therapy Promotes Breast Cancer Metastasis in a TLR4-Dependent Manner
Authors: Volk-Draper Lisa , Hall Kelly , Griggs Caitlin , Rajput Sandeep , Kohio Pascaline , DeNardo David , Ran Sophia
Published: March 2023

Legend for Supplementary Figures S1-S4.
Figure S4 from Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Authors: Tao Shasha , Wang Shue , Moghaddam Seyed Javad , Ooi Aikseng , Chapman Eli , Wong Pak K. , Zhang Donna D.
Published: March 2023

Figure S4. Larger images of the IHC analyses shown in Figure 2B.
Data Supplement from TRIB1 Supports Prostate Tumorigenesis and Tumor-Propagating Cell Survival by Regulation of Endoplasmic Reticulum Chaperone Expression
Authors: Mashima Tetsuo , Soma-Nagae Taeko , Migita Toshiro , Kinoshita Ryoko , Iwamoto Atsushi , Yuasa Takeshi , Yonese Junji , Ishikawa Yuichi , Seimiya Hiroyuki
Published: March 2023

Supplementary Materials and Methods, Supplementary Reference, Supplementary Figure Legends
Figure S1 from Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Authors: Tao Shasha , Wang Shue , Moghaddam Seyed Javad , Ooi Aikseng , Chapman Eli , Wong Pak K. , Zhang Donna D.
Published: March 2023

Figure S1. siRNA#3 and siRNA#5 specifically reduce the protein levels of Nrf2 and HMOX1 without affecting ERK and p53.
Supplementary Table S2 from Transcriptional Dynamics in Colorectal Carcinogenesis: New Insights into the Role of c-Myc and miR17 in Benign to Cancer Transformation
Authors: Ben-David Eyal , Bester Assaf C. , Shifman Sagiv , Kerem Batsheva
Published: March 2023

Functional enrichment in modules.
Data Supplement from Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells
Authors: Izumi Hideki , Kaneko Yasuhiko
Published: March 2023

Supplementary Figure S12. Cotransfection of Trim32/3A and MYCN shRNA increased the percentage of neuroblastoma cells showing NuMA-ACD. A, Immunoblot of Trim32/3A and MYCN expressing SK-N-DZ cells transfected with both Trim32/3A expression vector and control shRNA or MYCN shRNA. Immunoblot of γ-tubulin served as a loading control. B, Percent of SK-N-DZ cells in NuMA-, sympatric, or complete ACD transfected with both Trim32/3A expression vector and control shRNA or MYCN shRNA. Error bars represent SEM from three experiments. NuMA-ACD was more frequent in SK-N-DZ cells treated with Trim32/3A and MYCN shRNA than in those treated with Trim32/3A shRNA only (P=0.0068).
Data Supplement from FLT3 Kinase Inhibitor TTT-3002 Overcomes Both Activating and Drug Resistance Mutations in FLT3 in Acute Myeloid Leukemia
Authors: Ma Hayley S. , Nguyen Bao , Duffield Amy S. , Li Li , Galanis Allison , Williams Allen B. , Brown Patrick A. , Levis Mark J. , Leahy Daniel J. , Small Donald
Published: March 2023

Supplemental Table 1. Proliferation IC50 for treatment of FLT3 activating mutant cells. Supplemental Table 2. FLT3 mutational status and proliferation IC50 of AML patient samples. Supplemental Table 3. Phospho-FLT3 IC50 in plasma culture conditions. Supplemental Figure 1. TTT-3002 inhibits downstream targets of FLT3 signaling in Ba/F3-D835Y/ITD cells. Supplemental Figure 2. TTT-3002 and CEP-701 demonstrate minimal protein binding interference due to human serum albumin.
Data Supplement from AXL Mediates Resistance to Cetuximab Therapy
Authors: Brand Toni M. , Iida Mari , Stein Andrew P. , Corrigan Kelsey L. , Braverman Cara M. , Luthar Neha , Toulany Mahmoud , Gill Parkash S. , Salgia Ravi , Kimple Randall J. , Wheeler Deric L.
Published: March 2023

Supplemental Materials and Methods. Supplemental materials and methods including qPCR primers and in vivo PDX establishment and characterization.
Supplementary Figures 1 - 3 from Reducing CD73 Expression by IL1β-Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors
Authors: Chatterjee Shilpak , Thyagarajan Krishnamurthy , Kesarwani Pravin , Song Jin H. , Soloshchenko Myroslawa , Fu Jianing , Bailey Stefanie R. , Vasu Chenthamarkshan , Kraft Andrew S. , Paulos Chrystal M. , Yu Xue-Zhong , Mehrotra Shikhar
Published: March 2023

Supplementary Figure 1: Differential cytolytic potential and activation of Th17IL-1β cells in culture. Supplementary figure 2: Ectonucleotidase expression and persistence of different Th17 cells. Supplementary figure 3: Schematic summary highlighting the effect of different Th17 programming conditions on anti-tumor function.
Supplementary Table 2 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling
Authors: Schoumacher Marie , Hurov Kristen E. , Lehár Joseph , Yan-Neale Yan , Mishina Yuji , Sonkin Dmitriy , Korn Joshua M. , Flemming Daisy , Jones Michael D. , Antonakos Brandon , Cooke Vesselina G. , Steiger Janine , Ledell Jebediah , Stump Mark D. , Sellers William R. , Danial Nika N. , Shao Wenlin
Published: March 2023

XLSX file - 243KB, This table summarizes all significant genetic features that differentiate sensitive versus insensitive cell lines for TNKSi/MEKi combination. The first sheet lists all cell lines for each group. The second sheet lists all genetic features that are enriched in the sensitive group, using a False Discovery Rate (FDR) p-value lower than 0.25.
Supplementary Figure 1 from Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis
Authors: Gopinathan Lakshmi , Tan Shawn Lu Wen , Padmakumar V. C. , Coppola Vincenzo , Tessarollo Lino , Kaldis Philipp
Published: March 2023

PDF file - 432KB, Generation of cyclin A2 conditional knockout mice.
Data Supplement from Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Authors: Yori Jennifer L. , Lozada Kristen L. , Seachrist Darcie D. , Mosley Jonathan D. , Abdul-Karim Fadi W. , Booth Christine N. , Flask Chris A. , Keri Ruth A.
Published: March 2023

Supplementary Figure S5. Animal monitoring of mouse weight and ex-vivo tumor weights for drug toxicity.
Supplementary Table S6 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

Levels of mRNA expression for 13 CRC cell lines analyzed using RNA-Seq. Transcript levels are given as reads per kilobase per million mapped (RPKM) values.
Supplemental Dataset 3 from AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
Authors: Wilson Catherine , Ye Xiaofen , Pham Thinh , Lin Eva , Chan Sara , McNamara Erin , Neve Richard M. , Belmont Lisa , Koeppen Hartmut , Yauch Robert L. , Ashkenazi Avi , Settleman Jeff
Published: March 2023

Supplemental Dataset 3. Tumor cell line profile of docetaxel in combination with R428
Supplementary Table 8 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

XLSX file - 15KB, Intersecting top 5% of mutated genes based on the proportion of affected samples between CRC cell lines and TCGA-analyzed primary cancers for non-hypermutated and hypermutated MSI-H samples.
Supplementary Table 6 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

XLSX file - 7438KB, Levels of mRNA expression for 13 CRC cell lines analyzed using RNA-Seq. Transcript levels are given as reads per kilobase per million mapped (RPKM) values.
Supplementary Methods from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

PDF file - 91KB