bluuebunny/crossref_metadata_2025 huggingface dataset:
Decreased Haemoglobin Level Measured at Admission Predicts Long Term Mortality after the First Episode of Acute Pulmonary Embolism
Authors: Justyna Aleksandra , Dzikowska-Diduch Olga , Pacho Szymon , Ciurzyński Michał , Skowrońska Marta , Wyzgał-Chojecka Anna , Piotrowska-Kownacka Dorota , Pruszczyk Katarzyna , Pucyło Szymon , Sikora Aleksandra , Pruszczyk Piotr
Published: November 2022

Background: Decreased hemoglobin concentration was reported to predict long term prognosis in patients various cardiovascular diseases including congestive heart failure and coronary artery disease. We hypothesized that hemoglobin levels may be useful for post discharge prognostication after the first episode of acute pulmonary embolism. Therefore, the aim of the current study was to evaluate a potential prognostic value of a decreased hemoglobin levels measured at admission due to the first episode of acute PE for post discharge all cause mortality during at least 2 years follow up. Methods: This was a prospective, single-center, follow-up, observational, cohort study of consecutive survivors of the first PE episode. Patients were managed according to ESC current guidelines. After the discharge, all PE survivors were followed for at least 24 months in our outpatient clinic. Results: During 2 years follow-up from the group of 402 consecutive PE survivors 29 (7.2%) patients died. Non-survivors were older than survivors 81 years (40–93) vs. 63 years (18–97) p < 0.001 presented higher sPESI 2 (0–4) vs. 1 (0–5), p < 0.001 driven by a higher frequency of neoplasms (37.9% vs. 16.6%, p < 0.001); and had lower hemoglobin (Hb) level at admission 11.7 g/dL (6–14.8) vs. 13.1 g/dL (3.1–19.3), p < 0.001. Multivariable analysis showed that only Hb and age significantly predicted all cause post-discharge mortality. ROC analysis for all cause mortality showed AUC for hemoglobin 0.688 (95% CI 0.782–0.594), p < 0.001; and for age 0.735 (95% CI 0.651–0.819) p < 0.001. A group of 59 subjects with hemoglobin < 10.5 g/dL showed mortality rate of 16.9% (OR for mortality 4.19 (95% CI 1.82–9.65), p-value < 0.00, while among 79 patients with Hb > 14.3 g/dL only one death was detected. Interestingly, patients in age > 64 years hemoglobin levels < 13.2 g/dL compared to patients in the same age but with >13.2 g/dL showed OR 3.6 with 95% CI 1.3–10.1 p = 0.012 for death after the discharge. Conclusions: Lower haemoglobin measured in the acute phase especially in patients in age above 64 years showed significant impact on the prognosis and clinical outcomes in PE survivors.
Computer-Assisted Differential Diagnosis of Pyoderma Gangrenosum and Venous Ulcers with Deep Neural Networks
Authors: Birkner Mattias , Schalk Julia , von den Driesch Peter , Schultz Erwin S.
Published: November 2022

(1) Background: Pyoderma gangrenosum (PG) is often situated on the lower legs, and the differentiation from conventional leg ulcers (LU) is a challenging task due to the lack of clear clinical diagnostic criteria. Because of the different therapy concepts, misdiagnosis or delayed diagnosis bears a great risk for patients. (2) Objective: to develop a deep convolutional neural network (CNN) capable of analysing wound photographs to facilitate the PG diagnosis for health professionals. (3) Methods: A CNN was trained with 422 expert-selected pictures of PG and LU. In a man vs. machine contest, 33 pictures of PG and 36 pictures of LU were presented for diagnosis to 18 dermatologists at two maximum care hospitals and to the CNN. The results were statistically evaluated in terms of sensitivity, specificity and accuracy for the CNN and for dermatologists with different experience levels. (4) Results: The CNN achieved a sensitivity of 97% (95% confidence interval (CI) 84.2–99.9%) and outperformed dermatologists, with a sensitivity of 72.7% (CI 54.4–86.7%) significantly (p < 0.03). However, dermatologists achieved a slightly higher specificity (88.9% vs. 83.3%). (5) Conclusions: For the first time, a deep neural network was demonstrated to be capable of diagnosing PG, solely on the basis of photographs, and with a greater sensitivity compared to that of dermatologists.
Diurnal Oscillations of Fibrinolytic Parameters in Patients with Acute Myocardial Infarction and Their Relation to Platelet Reactivity: Preliminary Insights
Authors: Boinska Joanna , Koziński Marek , Kasprzak Michał , Ziołkowski Michał , Kubica Jacek , Rość Danuta
Published: November 2022

There is limited information about diurnal changes in fibrinolysis parameters after acute myocardial infarction (AMI) and their relationship with on-treatment platelet reactivity. The aim of this study was to assess tissue plasminogen activator (t-PA), plasminogen activator inhibitor type-1 (PAI-1), α2-antiplasmin (α2-AP) activity, and plasmin–antiplasmin (PAP) complexes in 30 AMI patients taking dual antiplatelet therapy (DAPT), i.e., acetylsalicylic acid and clopidogrel. Fibrinolytic parameters were assessed at four time points (6 a.m., 10 a.m., 2 p.m., and 7 p.m.) on the third day after AMI using immunoenzymatic methods. Moreover, platelet reactivity was measured using multiple-electrode aggregometry, to assess potential differences in fibrinolytic parameters in low/high on-aspirin platelet reactivity and low/high on-clopidogrel platelet reactivity subgroups of patients. We detected significant diurnal oscillations in t-PA and PAI-1 levels in the whole study group. However, PAP complexes and α2-AP activity were similar at the analyzed time points. Our study reveals a potential impact of DAPT on the time course of fibrinolytic parameters, especially regarding clopidogrel. We suggest the presence of diurnal variations in t-PA and PAI-1 concentrations in AMI patients, with the highest levels midmorning, regardless of platelet reactivity. Significantly elevated levels of PAI-1 during the evening hours in clopidogrel-resistant patients may increase the risk of thrombosis.
Myocardial Injury in Hospitalized Patients with Myasthenia Gravis
Authors: Chen Hongxi , Kong Lingyao , Zhang Ying , Lin Xue , Shi Ziyan , Du Qin , Wang Xiaofei , Lang Yanlin , Cai Linjun , Mou Zichao , Luo Wenqin , Li Shuangjie , Zhou Hongyu
Published: November 2022

Objective: To investigate the clinical characteristics and outcome of myocardial injury in patients with myasthenia gravis (MG). Methods: We retrospectively searched medical records to screen hospitalized patients with MG at our hospital. The troponin T (TnT) levels were deemed necessary to be performed based on the patient’s clinical symptoms and were used as biomarkers of myocardial injury. The patients’ demographic and clinical information were collected. Death was the primary outcome. Results: A total of 336 patients with MG measured TnT levels and were included in the final analysis. The male MG patients with elevated TnT levels had a higher prevalence of infection (56.8% vs. 30.0%, p = 0.001) and myasthenic crisis (37.5% vs. 13.3%, p = 0.001) than those with normal TnT levels. Meanwhile, the female MG patients with elevated TnT levels were older (56.0 (16.6) vs. 49.2 (17.2)) years old, p = 0.007] and had a higher prevalence of infection (65.4% vs. 32.1%, p < 0.001), myasthenic crisis (33.6% vs. 17.9%, p = 0.015), and thymoma (38.5% vs. 16.7%, p = 0.001) than those with normal TnT levels. Older age (coef. = 0.004; p = 0.034), infection (coef. = 0.240; p = 0.001), myasthenic crisis (coef. = 0.312; p < 0.001), thymoma (coef. = 0.228; p = 0.001), and ICI therapy (coef. = 1.220; p < 0.001) were independent risk predictors for increasing log TnT levels. Thirty-seven patients died during hospitalization. High log TnT levels (OR = 8.818; p < 0.001), female sex (OR = 0.346; p = 0.023), thymoma (OR = 5.092; p = 0.002), and infection (OR = 14.597; p < 0.001) were independent risk predictors of death. Conclusions: Our study revealed that the surveillance of myocardial injury biomarkers in MG patients might be beneficial.
Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?
Authors: Crimì Alberto , Binitie Odion T. , Crimì Filippo , Letson G. Douglas , Joyce David M.
Published: November 2022

(1) Background: Pelvic Chondrosarcomas (CS) have a poor prognosis. The grade is the most important survival predictor; other factors are periacetabular location and Dedifferentiated CS subtype. The aim of the study is to investigate a series of CS of the pelvis, to analyze the prognostic factors that affect outcomes and to demonstrate how the use of intraoperative navigation can reduce the complications without worse outcomes. (2) Methods: Retrospective study on 35 patients (21 M, 14 F), median age at surgery 54 years (IQR 41–65), with pelvic CS, treated with hemipelvectomy under navigation guidance. (3) Results: 30 high-grade CS and 5 low-grade CS; mean follow-up 51.4 months. There was a positive linear correlation between the tumor volume and the presence of local recurrence at follow-up. The mean survival time of patients with larger chondrosarcoma volume was lower, but not significantly so. Lower MSTS score was associated with significantly lower survival time (p < 0.001). (4) Conclusion: in this series overall survival, LR and distant metastasis were comparable with recent literature, while complication rate was lower compared to similar series without the use of navigation. There was a correlation between tumor volume and local recurrence rate but not with the presence of metastasis at follow up.
Surgical Strategies to Dissect around the Superior Mesenteric Artery in Robotic Pancreatoduodenectomy
Authors: Takagi Kosei , Umeda Yuzo , Yoshida Ryuichi , Fuji Tomokazu , Yasui Kazuya , Kimura Jiro , Hata Nanako , Mishima Kento , Yagi Takahito , Fujiwara Toshiyoshi
Published: November 2022

The concept of the superior mesenteric artery (SMA)-first approach has been widely accepted in pancreatoduodenectomy. However, few studies have reported surgical approaches to the SMA in robotic pancreatoduodenectomy (RPD). Herein, we present our surgical strategies to dissect around the SMA in RPD. Among the various approaches, our standard protocol for RPD included the right approach to the SMA, which can result in complete tumor resection in most cases. In patients with malignant diseases requiring lymphadenectomy around the SMA, we developed a novel approach by combining the left and right approaches in RPD. Using this approach, circumferential dissection around the SMA can be achieved through both the left and right sides. This approach can also be helpful in patients with obesity or intra-abdominal adhesions. The present study summarizes the advantages and disadvantages of both the approaches during RPD. To perform RPD safely, surgeons should understand the different surgical approaches and select the best approach or a combination of different approaches, depending on demographic, anatomical, and oncological factors.
Could Short Stems THA Be a Good Bone-Saving Option Even in Obese Patients?
Authors: Saracco Michela , Fidanza Andrea , Necozione Stefano , Maccauro Giulio , Logroscino Giandomenico
Published: November 2022

Short femoral stems, with preservation of the femoral bone stock, are commonly used in recent years for hip replacement in younger and more active patients. Obesity is increasingly spreading even in the younger population. The aim of this case-series study is to evaluate short stems compared to traditional hip prostheses in the obese population. A total of 77 consecutive patients with a BMI greater than or equal to 30 Kg/m2 were enrolled in this prospective study and were divided into two groups: 49 patients have been implanted with short stems while 28 patients were implanted with traditional stems. All the patients were treated for primary osteoarthritis or avascular necrosis and all the stems were implanted by the same surgeon using a posterior approach. Clinical (Harris Hip Score—HHS, Western Ontario and McMaster Universities Osteoarthritis Index—WOMAC, visual analogue scale—VAS, 12-item Short Form Health Survey—SF-12) and radiographic outcomes were recorded. Radiological evaluations were carried out by three different blinded surgeons. A statistical analysis was performed (chi-square, t-test, Wilcoxon Rank Sum Test, 2-factor ANOVA). At a mean follow-up of 42.6 months both groups showed a marked improvement in pain and in the clinical scores between pre- and post-surgical procedures (p < 0.05) with no significant differences between the two groups at last follow-up (p > 0.05). The radiological evaluations, with high concordance correlation between the three blinded surgeons (ICC consistently >0.80), showed good positioning and osseointegration in all cases, with no significant differences in the restoration of the joint geometry and complications. No revisions were recorded during the follow-up period. In conclusion, short stems appear to be a good option for bone preservation even in obese patients, showing comparable results to traditional implants.
Ageing and Osteoarthritis Synergically Affect Human Synoviocyte Cells: An In Vitro Study on Sex Differences
Authors: Veronesi Francesca , Contartese Deyanira , Borsari Veronica , Pagani Stefania , Fini Milena , De Mattei Monica , Tschon Matilde
Published: November 2022

Osteoarthritis is a chronic inflammatory disease that affects all of the joints, especially those of the elderly. Aging is a natural and irreversible biological process implicated in the pathophysiology of many chronic diseases, such as osteoarthritis. Inflammation and oxidative stress are the main factors involved in osteoarthritis and aging, respectively, with the production of several pro-inflammatory cytokines such as Interleukin 1β (IL1β) and reactive oxygen species. The aim of the study was to set-up an in vitro model of osteoarthritis and aging, focusing on the sex differences by culturing male and female fibroblast-like synoviocytes (FLSs) with IL1β, hydrogen peroxide (H2O2), IL1β+H2O2 or a growth medium (control). IL1β+H2O2 reduced the cell viability and microwound healing potential, increased Caspase-3 expression and reactive oxygen species and IL6 production; IL1β increased IL6 production more than the other conditions did; H2O2 increased Caspase-3 expression and reactive oxygen species production; Klotho expression showed no differences among the treatments. The FLSs from female donors demonstrated a better response capacity in unfavorable conditions of inflammation and oxidative stress than those from the male donors did. This study developed culture conditions to mimic the aging and osteoarthritis microenvironment to evaluate the behavior of the FLSs which play a fundamental role in joint homeostasis, focusing on the sex-related aspects that are relevant in the osteoarthritis pathophysiology.
Thoracic UltrasONOgraphy Reporting: The TUONO Study
Authors: Calamai Italo , Greco Massimiliano , Finazzi Stefano , Savi Marzia , Vitiello Gaia , Garbero Elena , Spina Rosario , Montisci Andrea , Mongodi Silvia , Bertolini Guido
Published: November 2022

Lung ultrasound (LUS) is a validated technique for the prompt diagnosis and bedside monitoring of critically ill patients due to its availability, safety profile, and cost-effectiveness. The aim of this work is to detect similarities and differences among LUS reports performed in ICUs and to provide a common ground for an integrated report form. We collected all LUS reports during an index week in 21 ICUs from the GiViTI network. First, we considered signs, chest areas, and terminology reported. Then, we compared different report structures and categorized them as structured reports (SRs), provided with a predefined model form, and free unstructured text reports (FTRs) that had no predetermined structure. We analyzed 171 reports from 21 ICUs, and 59 reports from 5 ICUs were structured. All the reports presented a qualitative description that mainly focused on the presence of B-lines, consolidations, and pleural effusion. Zones were defined in 66 reports (39%). In SRs, a complete examination of all the regions was more frequently achieved (96% vs. 74%), and a higher impact on therapeutic strategies was observed (17% vs. 6%). LUS reports vary significantly among different centers. Adopting an integrated SR seems to promote a systematic approach in scanning and reporting, with a potential impact on LUS clinical applications.
Case Series of Acute Meconium Peritonitis Secondary to Perforation of the Ileum in the Antepartum Period
Authors: Piccioni Maria , Merlino Lucia , D’Ovidio Giulia , Del Prete Federica , Galli Valerio , Petrivelli Lucia , Vena Flaminia , D’Ambrosio Valentina , Giancotti Antonella , Brunelli Roberto
Published: November 2022

Perforation of the ileum in the antepartum period resulting in meconial peritonitis is a condition that, although rare, is burdened by several complications. In 80–90% of cases, meconial ileus is the first manifestation of a disease, cystic fibrosis. In the remaining 10–20% of cases, it is caused by other situations, such as prematurity. In most cases, the diagnosis of meconial ileus occurs after birth, although in some cases it can be suspected prenatally, with the finding of a hyperechoic intestine on second trimester ultrasound. The prognosis depends on the gestational age, the location of the obstruction and the presence of fetal abnormalities. Mortality is very high and the recovery of intestinal function in the postoperative course is very high risk. In this case series, we describe two meconial peritonitis and our experience at the center.
Formulation and Process Optimization of Rauvolfia serpentina Nanosuspension by HPMC and In Vitro Evaluation of ACE Inhibitory Potential
Authors: Touqeer Syeeda Iram , Jahan Nazish , Abbas Naseem , Ali Ahsan
Published: November 2022

Angiotensin converting enzyme (ACE) overactivation is one of the primary causes of hypertension, which leads to cardiovascular disorders all over the world. In the scientific world, nanosuspension is a novel area of study that could offer an alternative treatment for active pharmaceuticals that are not well soluble in water. Since active compounds’ bioavailability is reduced by their poor solubility, there are eventually fewer applications. Drug solubility, dissolving rate, and bioavailability are improved by nanosuspension, which shrinks medication particle size into the nanoscale range and boosts the surface area to volume ratio of the drug. There is a need to prepare Rauvolfia serpentina’s nanosuspension in order to get around some of the major challenges that it faces because of its poor solubility and wide range of biological activities. Using the antisolvent precipitation approach, a nanosuspension of Rauvolfia serpentina was created with hydroxy propyl methyl cellulose (HPMC). Rouvolfia serpentina nanosuspensions were prepared using a design of expert (DOE) approach, which allowed for the evaluation of key process parameters. To get an optimal sample, the effects of stabilizer concentration and anti-solvent volume on particle size, zeta potential, and PdI using CCD-RSM were investigated. Using the substrate Hippuryl-histidyl-leucine, the in vitro ACE inhibitory potential was assessed. On human erythrocytes, the safety of nanosuspension was evaluated in vitro. The ideal value of independent variables was discovered to be 0.25% w/v in order to achieve the desired response. Using scanning electron microscopy, the morphology of optimized nanosuspension was discovered to be rod-shaped (SEM). Compared to nanoformulation, crude extract had higher ACE inhibitory potential (83.11%). Human erythrocytes were found to be unaffected by nano-sized particles.
Isolation and Characterization of Ruminal Yeast Strain with Probiotic Potential and Its Effects on Growth Performance, Nutrients Digestibility, Rumen Fermentation and Microbiota of Hu Sheep
Authors: Wang Yao , Li Zihao , Jin Wei , Mao Shengyong
Published: November 2022

Yeast strains are widely used in ruminant production. However, knowledge about the effects of rumen native yeasts on ruminants is limited. Therefore, this study aimed to obtain a rumen native yeast isolate and investigate its effects on growth performance, nutrient digestibility, rumen fermentation and microbiota in Hu sheep. Yeasts were isolated by picking up colonies from agar plates, and identified by sequencing the ITS sequences. One isolate belonging to Pichia kudriavzevii had the highest optical density among these isolates obtained. This isolate was prepared to perform an animal feeding trial. A randomized block design was used for the animal trial. Sixteen Hu sheep were randomly assigned to the control (CON, fed basal diet, n = 8) and treatment group (LPK, fed basal diet plus P. kudriavzevii, CFU = 8 × 109 head/d, n = 8). Sheep were housed individually and treated for 4 weeks. Compared to CON, LPK increased final body weight, nutrient digestibility and rumen acetate concentration and acetate-to-propionate ratio in sheep. The results of Illumina MiSeq PE 300 sequencing showed that LPK increased the relative abundance of lipolytic bacteria (Anaerovibrio spp. and Pseudomonas spp.) and probiotic bacteria (Faecalibacterium spp. and Bifidobacterium spp.). For rumen eukaryotes, LPK increased the genera associated with fiber degradation, including protozoan Polyplastron and fungus Pichia. Our results discovered that rumen native yeast isolate P. kudriavzevii might promote the digestion of fibers and lipids by modulating specific microbial populations with enhancing acetate-type fermentation.
Virtual IBAN as a Service in the Law of the European Union and Poland
Authors: Grabowski Michał
Published: November 2022

The purpose of this paper is to present the two existing virtual account models functioning in the European Union, examine their legal validity and identify the legal challenges related to the functioning of these models. The first model, Mass Payment Accounts, which is related to virtual accounts rather than to virtual IBANs, is the model where the licensed financial institution only provides a business payment (settlement) account, with technical subaccounts, to one of their business clients. The functionality of the subaccounts is limited to reflect and distinguish the incoming payments. The second and more complex model is the vIBAN solution, where the licensed payment institution provides, to another licensed financial institution, indirect access to local payment schemes (hereinafter referred to as “vIBAN”). To confirm the legal validity and identify the potential risks of vIBAN services, EU law was analysed with some insights from Polish law. The reason for introducing vIBAN services is the difficulty for certain payment service providers to participate in so-called designated payment systems. Designated payment systems are usually the most widespread local payment systems. The reason for the different treatment of these designated systems is banking systemic risk, understood as a situation where a default by a system participant may result in a default by other participants. Consequently, even if a given payment service provider can obtain its own IBAN number, there is often no possibility for it to participate in designated payment schemes. Bearing in mind the different rules in the case of designated payment systems, the legality of vIBAN services in the EU law is justified by the principle of free movement of services, the principle of equal access to payment schemes and the obligation of the credit institutions to provide banking and non-banking participants with credit institution payment account services on an objective, non-discriminatory and proportionate basis. However, there are various challenges related to the functioning of vIBAN services, such as the overlapping of certain AML/CFT obligations, enforcement of administrative and court seizures, AML-related blocking of vIBANs and consistency of money transfer sender data with the Fund Transfer Regulation. The most pressing challenges requiring prompt regulation on the European level are related to the applicable deposit protection scheme, as well as to specific Member States’ administrative restrictions, which can cause difficulties in offering vIBAN services to business entities.
Modelling Floodplain Vegetation Response to Groundwater Variability Using the ArcSWAT Hydrological Model, MODIS NDVI Data, and Machine Learning
Authors: Muhury Newton , Apan Armando A. , Marasani Tek N. , Ayele Gebiaw T.
Published: November 2022

This study modelled the relationships between vegetation response and available water below the soil surface using Terra’s moderate resolution imaging spectroradiometer (MODIS), Normalised Difference Vegetation Index (NDVI), and soil water content (SWC). The Soil & Water Assessment Tool (SWAT) interface known as ArcSWAT was used in ArcGIS for the groundwater analysis. The SWAT model was calibrated and validated in SWAT-CUP software using 10 years (2001–2010) of monthly streamflow data. The average Nash-Sutcliffe efficiency during the calibration and validation was 0.54 and 0.51, respectively, indicating that the model performances were good. Nineteen years (2002–2020) of monthly MODIS NDVI data for three different types of vegetation (forest, shrub, and grass) and soil water content for 43 sub-basins were analysed using the WEKA, machine learning tool with a selection of two supervised machine learning algorithms, i.e., support vector machine (SVM) and random forest (RF). The modelling results show that different types of vegetation response and soil water content vary in the dry and wet seasons. For example, the model generated high positive relationships (r = 0.76, 0.73, and 0.81) between the measured and predicted NDVI values of all vegetation in the sub-basin against the groundwater flow (GW), soil water content (SWC), and combination of these two variables, respectively, during the dry season. However, these relationships were reduced by 36.8% (r = 0.48) and 13.6% (r = 0.63) against GW and SWC, respectively, in the wet season. Our models also predicted that vegetation in the top location (upper part) of the sub-basin is highly responsive to GW and SWC (r = 0.78, and 0.70) during the dry season. Although the rainfall pattern is highly variable in the study area, the summer rainfall is very effective for the growth of the grass vegetation type. The results predicted that the growth of vegetation in the top-point location is highly dependent on groundwater flow in both the dry and wet seasons, and any instability or long-term drought can negatively affect these floodplain vegetation communities. This study has enriched our knowledge of vegetation responses to groundwater in each season, which will facilitate better floodplain vegetation management.
Experience of Community Resilience in Rural Areas around Heritage Sites in Quanzhou under Transition to a Knowledge Economy
Authors: Shen Jing , Chou Rung-Jiun , Zhu Rong , Chen Shun-He
Published: November 2022

With the transition to a knowledge economy becoming an important aim, this qualitative study examines rural communities (Yongning and Xunpu) near heritage sites in Quanzhou, China. “Pu Jing” and exhibition space are connected with the inheritance and creation of intangible cultural heritage in order to form a knowledge economy with unique local characteristics around these sites. Beliefs and customs that reconstruct social values are integrated with heritage conservation. Economic competition and social capital restructuring strengthen social identification and benefit building community resilience. Combining with the “Local Tourism Alliance” activities organized by local organizations is important when developing innovative education and tourism activities. The innovation-oriented rural revitalization strategy has promoted community resilience in rural areas around the heritage sites, enhanced local area values, and encouraged social and economic efficiency.
Spatial and Temporal Dynamics of Wetlands in Guangdong-Hong Kong-Macao Greater Bay Area from 1976 to 2019
Authors: Liu Kai , Cao Jingjing , Lu Minying , Li Qian , Deng Haojian
Published: November 2022

Wetland ecosystems contain rich natural resources and vital ecological functions, and the investigation of spatial and temporal evolution characteristics of wetlands and their driving factors is critical for the management and conservation of wetlands. This study aimed to explore the spatial and temporal dynamics of wetlands in the Guangdong–Hong Kong–Macao Greater Bay Area (GBA) from 1976 to 2019 using multi-source remote sensing data (DISP KH-9, Landsat, and GaoFen-1), combing with the object-based classification method and landscape invasion index, and further analyze the driving forces affecting the spatial and temporal evolution of wetlands. The results showed that: (1) The total area of wetlands in the GBA showed a trend to first increase and then stabilize from 1976 to 2019. (2) The rapid development of aquaculture led to a continuous increase in aquaculture ponds and offshore aquaculture and a flat change in the middle and late stages, the area of mangroves declined substantially before 2000 and has gradually recovered since then, the invasion of various types of wetlands by built-up land is increasing, and wetlands are becoming increasingly fragmented. (3) The wetland changes in the GBA are the result of a combination of natural factors and human activities. Environmental conditions represent the basis for wetland dynamics, while the population, socio-economics, and policies are important drivers of wetland evolution. The findings will be beneficial to the understanding of wetland dynamic changes in the GBA over the past 40 years, and helpful to the scientific management and sustainable development of wetlands.
Immunomodulatory Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Allergic Airway Disease
Authors: Kim Sung-Dong , Cho Kyu-Sup
Published: November 2022

Mesenchymal stem cells (MSCs) have been reported as promising candidates for the treatment of various diseases, especially allergic diseases, as they have the capacity to differentiate into various cells. However, MSCs itself have several limitations such as creating a risk of aneuploidy, difficulty in handling them, immune rejection, and tumorigenicity, so interest in the extracellular vesicles (EVs) released from MSCs are increasing, and many studies have been reported. Previous studies have shown that extracellular vesicles (EVs) produced by MSCs are as effective as the MSCs themselves in suppression of allergic airway inflammation through the suppression of Th2 cytokine production and the induction of regulatory T cells (Treg) expansion. EVs are one of the substances secreted by paracrine induction from MSCs, and because it exerts its effect by delivering contents such as mRNA, microRNA, and proteins to the receptor cell, it can reduce the problems or risks related to stem cell therapy. This article reviews the immunomodulatory properties of MSCs-derived EVs and their therapeutic implications for allergic airway disease.
Development of Native Essential Oils from Forestry Resources in South Korea
Authors: Park Chanjoo , Woo Heesung
Published: November 2022

South Korea’s forests occupy approximately 70% of the mainland, therefore, there is considerable potential for waste coming from the forest. Extracting essential oils from underutilised biomass is an economic and sustainable method for the production of high-added-value products. These days, countries’ ownership of domestic natural resources is becoming vital, so there is an urgent need for developing the essential oils from native plants. To increase the value of native essential oils in South Korea, the National Institute of Forest Science (NiFoS) established the  to develop the native essential oils as well as develop more research infrastructure by sharing information on native essential oils and enhancing their value. We review the selected essential oils which are listed in the  from the literature on major chemical constituents, biological activity, and potential uses of essential oils. Those utilising forest resources for commercial essential oil production need to consider the stable supply of plant material in terms of forest management and conservation. Therefore, Pinaceae (Larix kaempferi, Pinus densiflora, Pinus koraiensis) and Cupressaceae (Chamaecyparis obtusa and Chamaecyparis pisifera) could be potential candidates for commercial essential oil as their waste materials are easily obtained from the plantation after forest management. With their unique fragrance and the bioactive compounds in their oils, potential candidates can be utilised in various industry sectors.
Twelve-Month Follow-Up of Different Dentinal Hypersensitivity Treatments by Photobiomodulation Therapy, Nd:YAG and Nd:YAP Lasers
Authors: Nammour Samir , El Mobadder Marwan , Namour Melanie , Brugnera Junior Aldo , Zanin Fatima , Brugnera Ana Paula , Geerts Sabine , Namour Amaury
Published: November 2022

In this retrospective study, data for three different laser-assisted approaches for the management of dentinal hypersensitivity (DH) was collected (n = 920 teeth). In total, 387 teeth were treated with photobiomodulation (PBM) therapy with 660 nm red light laser (PBM group), 327 were treated with the Nd:YAG laser (1064 nm) and 206 were treated with the Nd:YAP laser (1340 nm). To assess the effectiveness of each treatment, a visual analogue scale (VAS) was used, where zero represented no pain at all and ten represented the greatest pain. VAS was used before (T0), immediately after (T1), one week after (T2), four weeks after (T3), six months after (T4) and one year after treatment (T5). Means and standard deviations of VAS at different follow-up times were calculated. Values were compared within and between groups. Statistical significance was considered to be achieved when p-value was less than 0.05. Confidence level was proposed to be 99% with a P value lower than 0.001. Within groups, a statistically significant reduction was obtained when the mean value of VAS at T0 was compared with T5. At T5, the PBM group had the highest reduction of VAS (with mean value of 0), while the Nd:YAG and Nd:YAP groups had scores of 1.065 ± 0.674 and 4.665 ± 0.674, respectively. Conclusion: this retrospective study showed that PBM therapy and irradiation with Nd:YAG and Nd:YAP lasers are effective in managing DH pain. However, PBM therapy was the only procedure that showed complete pain relief at six and twelve months after treatment.
Early and Direct Endoscopic Stone Removal in the Moderate Grade of Acute Cholangitis with Choledocholithiasis Was Safe and Effective: A Prospective Study
Authors: Liang Chih-Ming , Chiu Yi-Chun , Lu Lung-Sheng , Wu Cheng-Kun , Sou Fai-Meng , Chiu Shao-Ming , Lee Yu-Chi , Huang Pao-Yuan , Chuah Seng-Kee , Kuo Chung-Mou
Published: November 2022

Background: Evidence supporting the feasibility of single-stage stone removal in patients with a moderate grade of acute cholangitis remains insufficient. The maximal size of a common bile-duct stone suitable for removal during a single-stage ERCP in a moderate grade of acute cholangitis is unknown. Methods: We prospectively enrolled 196 endoscopic retrograde cholangiopancreatography (ERCP)-naïve patients diagnosed with acute cholangitis and choledocholithiasis. For eligible patients, single-stage treatment involved stone removal at initial ERCP. Results: A total of 123 patients were included in the final analysis. The success rate of complete stone extraction was similar between patients with mild and moderate grades of acute cholangitis (89.2% vs. 95.9%; p = 0. 181). Complication rates were comparable between the two groups. In the moderate grade of the cholangitis group, among patients who underwent early single-stage ERCP, the length of hospitalization declined as short as the patients in the mild grade of cholangitis (10.6 ± 6.2 vs. 10.1 ± 5.1 days; p = 0.408). In the multivariate analysis, early ERCP indicated shorter hospitalization times (≤10 days) (odds ratio (OR), 3.981; p = 0.001). A stone size less than 1.5 cm presented a high success rate (98.0%) for complete stone removal. Conclusions: Single-stage retrograde endoscopic stone removal in mild and moderate grades of acute cholangitis may be safe and effective, which can obviate the requirement for a second session, thus reducing medical expenses. ClinicalTrials.gov: NCT03754491.
Temporal Instability, Wildernesses, and the Otherworld in Early Modern Drama
Authors: Rendall Edward B. M.
Published: November 2022

This article shows how temporal disorder diffuses into the wildernesses within early modern English drama. Those areas beyond the walls of cities and castles in—among other plays—The Two Gentlemen of Verona, Titus Andronicus, Romeo and Juliet, and Macbeth thus flit free from the temporal rules that construct a play’s quotidian world, and the conspicuous partitions that enclose an otherworld in medieval iconography no longer seem clear within them. I argue that these spaces enact an unfamiliar and chaotic ‘otherworld’ within quotidian space, and characters’ ventures into these outer regions at certain points resemble movements into an ‘afterlife’. Journeys into a wilderness, then, parallel a shift from one temporal sphere to another, and characters encounter a post-death state of being within the play’s present.
Pandemic, War, Natural Calamities, and Sustainability: Industry 4.0 Technologies to Overcome Traditional and Contemporary Supply Chain Challenges
Authors: Raja Santhi Abirami , Muthuswamy Padmakumar
Published: November 2022

Background: The supply chain ecosystem is becoming fragile and difficult to manage due to the complexities in its interlinked functions such as planning, procurement, production, logistics, distribution, and sales. Recently, organizations have started embarking on “Industry 4.0 technologies”, a name used to denote transformative modern-day technologies such as Artificial Intelligence, Machine Learning, automation and robotics, Internet of Things, Big Data Analytics, Blockchain, and so on to make faster decisions, optimize current practices, provide end-to-end transparency, increased collaboration, and superior warehouse management, which can collectively make it an “Intelligent supply chain”. However, a comprehensive understanding of the subject is required to understand the benefits and challenges of adopting them. Methods: Hence, the article aims to systematically review the literature to identify various challenges associated with supply chain management and provide an overview of the role of Industry 4.0 technologies in addressing them. In addition to traditional complexities, the uncertainties arising from contemporary challenges such as the COVID-19 pandemic, war, natural calamities, and difficulties businesses face in developing and adopting sustainable business practices. Results and Conclusions: The study shows that although it is hard to predict the level of disruptions during any global events, it is possible to be prepared through Industry 4.0 technologies that can give agility, transparency, and resilience to the supply chain.
Reduction in the Volumetric Wear of a Ball Polishing Tool Using Ultrasonic-Vibration-Assisted Polishing Process
Authors: Shiou Fang-Jung , Ding Zhao-Li , Lin Sun-Peng
Published: November 2022

Ultraprecision freeform polishing using a bonnet or a felt ball mounted on a polishing head plays an important role in the mold and lens production industries. The volumetric wear of a bonnet or a felt polishing ball is still a problem to be solved. The objective of this study was to develop an ultrasonic-vibration-assisted ball polishing process on a CNC machining center to improve the surface roughness of a STAVAX mold steel and to reduce the volumetric wear of the polishing ball. The optimal combination of the ultrasonic-vibration-assisted ball polishing parameters for a plane surface was determined by conducting the Taguchi L18 matrix experiments, ANOVA analysis, and verification experiments. The surface roughness of the polished specimens was improved from the burnished surface roughness of Ra 0.122 μm to Ra 0.022 μm. In applying the optimal plane surface ball burnishing and vibration-assisted spherical polishing parameters sequentially to a fine-milled and burnished aspherical lens surface carrier on a five-axis machining center, the surface roughness of Ra 0.014 μm was obtainable. The improvement in the volumetric wear of the polishing ball was about 62% using the vibration-assisted polishing process compared with the nonvibrated polishing process.
Collaborative Viewpoint Adjusting and Grasping via Deep Reinforcement Learning in Clutter Scenes
Authors: Liu Ning , Guo Cangui , Liang Rongzhao , Li Deping
Published: November 2022

For the robotic grasping of randomly stacked objects in a cluttered environment, the active multiple viewpoints method can improve grasping performance by improving the environment perception ability. However, in many scenes, it is redundant to always use multiple viewpoints for grasping detection, which will reduce the robot’s grasping efficiency. To improve the robot’s grasping performance, we present a Viewpoint Adjusting and Grasping Synergy (VAGS) strategy based on deep reinforcement learning which coordinates the viewpoint adjusting and grasping directly. For the training efficiency of VAGS, we propose a Dynamic Action Exploration Space (DAES) method based on ε-greedy to reduce the training time. To address the sparse reward problem in reinforcement learning, a reward function is created to evaluate the impact of adjusting the camera pose on the grasping performance. According to experimental findings in simulation and the real world, the VAGS method can improve grasping success and scene clearing rate. Compared with only direct grasping, our proposed strategy increases the grasping success rate and the scene clearing rate by 10.49% and 11%.
Two-Dimensional Doped Materials
Authors: Liu Junchi , Li Bo , Li Qiuqiu
Published: November 2022

The recently intensified research in atomically thick two-dimensional (2D) materials has been motivated by their unique properties and the possibility of updating the future electronic and optoelectronic technologies. Doping can change the band structure of a semiconductor and regulate its physical and chemical properties. Doping has a significant effect on the electronic structure of 2D materials due to their atomic thickness. Here, we present a tutorial review of 2D doped materials (except graphene), including various doping types and theoretical calculations, the preparation and characterization methods, and its multifunctional application. Finally, we will summarize by stating the current challenges and future opportunities in the development of 2D doped materials.
The Dollar Exchange Rate, Adjustment to the Purchasing Power Parity, and the Interest Rate Differential
Authors: Frömmel Michael , Vukovic Darko B. , Wu Jinyuan
Published: November 2022

This study applies a Markov switching error correction model to describe the single most important real exchange rate (Deutsche mark versus US dollar) over the flexible exchange rates period from 1973 to 2004. We show an alternative way of modelling non-linear adjustment to the purchasing power parity (PPP) besides standard threshold models. The model merges the two possible sources of non-linearity by additionally allowing the probability of a mean-reverting regime to increase with the distance from PPP. The interest rate differential as an additional determinant of real exchange rate behaviour in a Markov switching framework is introduced in the model. The study finds that the real dollar exchange rate during the post-Bretton Woods era is well described by a Markov switching error correction model with (PPP) as long-run equilibrium. There is one mean reversion regime where PPP and the interest parity condition are valid. Contrary, the second regime is characterised by persistent mean aversion, where a regime switch does not become more likely with increasing distance from PPP. The unconditional half-life of shocks is about 1.5 years.
Transient Wave Propagation in Functionally Graded Viscoelastic Structures
Authors: Pshenichnov Sergey , Ivanov Radan , Datcheva Maria
Published: November 2022

Transient wave processes in viscoelastic structures built from functionally graded material (FGM) still remain almost unexplored. In this article, the problem of the propagation of nonstationary longitudinal waves in an infinite viscoelastic layer of a FGM with plane–parallel boundaries is considered. The physical and mechanical parameters of the FGM depend continuously on the transverse coordinate, while the wave process propagates along the same coordinate. The viscoelastic properties of the material are taken into account employing the linear integral Boltzmann–Volterra relations. The viscoelastic layer of the FGM is replaced by a piecewise-homogeneous layer consisting of a large number of sub-layers (a package of homogeneous layers), thus approximating the continuous inhomogeneity of the FGM. A solution of a non-stationary dynamic problem for a piecewise-homogeneous layer is constructed and, using a specific example, the convergence of the results with an increase in the number of sub-layers in the approximating piecewise-homogeneous layer is shown. Furthermore, the problem of the propagation of nonstationary longitudinal waves in the cross section of an infinitely long viscoelastic hollow FGM cylinder, whose material properties continuously change along the radius, is also considered. The cylinder composed of the FGM is replaced by a piecewise-homogeneous one, consisting of a large number of coaxial layers, for which the solution of the non-stationary dynamic problem is constructed. For both the layer and the cylinder composed of a viscoelastic FGM, the results of calculating the characteristic parameters of the wave processes for the various initial data are presented. The influence of the viscosity and inhomogeneity of the material on the dynamic processes is demonstrated.
Why Is Aedes aegypti Moving South in South America?
Authors: Alonso Lucas Ernesto , Romeo Aznar Victoria , Solari Hernán Gustavo
Published: November 2022

Colonies of Aedes aegypti have been reported at increasingly southern locations. Is this feature a manifestation of climate change or the result of the mosquito’s adaptation? Answering the question requires the testing and comparison of results produced under different, competing, hypotheses. We address the problem using “AedesBA”, a detailed model of the mosquito Aedes aegypti that has been under development for about 20 years. The aim of the model is to promote understanding. We incorporate the recently discovered biological behavior of this mosquito: diapause. Namely, this is the laying of resistance eggs when the day light shortens, entering into the unfavorable season for reproduction in temperate climates, as described from laboratory experiments. When the model is challenged to answer the questions posed, it suggests that climate change, as experienced during the time of the field records, does not explain the observations. Furthermore, the standard climate change argument does not support a detailed analysis. In contrast, we find that while diapause is not expected to be a trait that is selected by natural conditions in a subtropical climate (simulations for Resistencia, AR), within temperate climates such as in Buenos Aires city (AR), there is pressure favoring the selection of the trait. As we move southward (the cities of Dolores, Azul, Tandil, and Mar del Plata), the pressure increases, while the probability of Aedes aegypti to become established in them decreases, being in accordance with the field observations. The model shows in addition that the field-observable effects of diapause depend on weather variables, especially precipitation, and the dynamics of the nutritional resources in the breeding sites.