bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of recurrent urinary tract infection (UTI) in University Hospital – approach of antibiotic resistance in clinical isolates
Authors: Alves Danilo Antonini , Guarnieri João Paulo de Oliveira , Bernardes Bruno Gaia , Silva Carlos Fernando Macedo da , Lancellotti Marcelo
Published: July 2022

The fifty-two bacteria were isolated from urinary tract infections in University Hospital in Sumaré, São Paulo State, Brazil.  These isolates were analyzed about their antibiotic resistance and their bacterial characteristics. Around percentage from these isolates were identified as belonging to Escherichia coli strains, followed by Klebsiella pneumoniae and Pseudomonas aeruginosa. The multiresistance profile (resistance profile major than four 4 antibiotic classes) were viewed in thirteen (13) strains of Escherichia coli, sixteen (16) strains in Klebsiella pneumoniae (being two (2) carbapenem resistant suggesting an existence of KPC strain). The results had demonstrated an indiscriminate antibiotic use concentrated in the increase of quinolones resistance (principally in ciprofloxacin use), and also the rise of KPC super bacteria.
Efeitos da aplicação de revestimentos biodegradáveis na conservação pós-colheita de tomate
Authors: Carvalho Samira Abreu , Figueiredo Neto Acácio , Costa Marylia de Sousa , Costa Josenara Daiane de Souza , Pereira Filho Antonio , Aragão Carlos Alberto
Published: July 2022

A cultura do tomate (Solanum lycopersicum L.) tem grande importância econômica e social para o Brasil. Entretanto, o tomate apresenta-se como um fruto de alta perecibilidade com vida de prateleira curta, o que requer métodos para sua conservação pós-colheita, por exemplo, o uso de revestimentos biodegradáveis. Diante disso, objetivou-se com esse trabalho, avaliar o efeito de revestimentos biodegradáveis à base de fécula de mandioca e glicerol, na qualidade pós-colheita do tomate variedade italiano hibrído “TY” à temperatura ambiente. O experimento foi conduzido no Laboratório de Armazenamento de Produtos Agrícolas (LAPA), da Universidade Federal do Vale do São Francisco (UNIVASF). Os tomates foram selecionados, lavados e revestidos com soluções de fécula de mandioca e glicerol nas concentrações de 5% e 1% respectivamente, armazenados à temperatura ambiente por doze dias, avaliando-se a cada dois dias quanto à perda de massa, firmeza do fruto, potencial hidrogeniônico, sólidos solúveis totais, acidez total titulável, relação sólidos solúveis e acidez total titulável e cor da casca. O delineamento experimental foi inteiramente casualizado em esquema fatorial 3 x 7 (revestimentos x tempo de armazenamento), com cinco repetições por tratamento. Os resultados foram submetidos à análise de variância, análise de regressão e as médias comparadas pelo teste de Tukey a 5% de probabilidade. As concentrações utilizadas na elaboração dos revestimentos FEC 5% e FEC 5% + GLIC 1% se destacaram na preservação de alguns atributos de qualidade, como perda de massa, firmeza, acidez e cor da casca. Os revestimentos utilizados foram caracterizados como alternativas possíveis para preservar a qualidade pós-colheita de tomates quando mantidos em condição de temperatura ambiente.
Sinais e sintomas sugestivos de disbiose intestinal na população brasileira: uma revisão de literatura
Authors: Reis Alice Cruz , Carvalho Gildelania da Silva , Sousa Natasha Luísa da Silva , Santos Gleyson Moura dos , Sousa Paulo Víctor de Lima , Barros Nara Vanessa dos Anjos
Published: July 2022

Objetivo: analisar os artigos que abordaram a prevalência de sinais e sintomas sugestivos de disbiose intestinal, na população brasileira, que utilizaram como instrumento o questionário de rastreamento metabólico (QRM) voltado a disbiose. Metodologia: trata-se de uma revisão bibliográfica da literatura científica da forma integrativa, a busca dos artigos foi realizada nas seguintes bases de dados eletrônicas: PubMed, Scielo, Web of Science e Google Acadêmico, utilizando como descritores: Microbiota intestinal, Disbiose intestinal e Hábitos alimentares. Após a estratégia de busca, foram analisados e selecionados estudos originais, desenvolvidos no Brasil, entre os anos de 2016 a 2020. Resultados: foram encontrados 465 artigos, entretanto, após o processo de triagem, 11 artigos foram escolhidos para a confecção do trabalho. Estes se tratavam de estudos transversais e todos utilizaram o QRM, entre outras estratégias para avaliarem a amostra. Os estudos analisados apontaram vários sinais e sintomas sugestivos de disbiose nas suas populações, mas que podem ser corrigidos. Os sintomas mais prevalentes dessa patologia foram: gases intestinais, desconforto abdominal, obesidade, cólicas, diarreias, prisão de ventre e constipação intestinal. Conclusão: O conhecimento produzido demonstrou a importância da utilização de instrumentos padronizados para avaliação do risco de disbiose e indicaram serem necessárias novas investigações sobre a temática.
Fatores que influenciam o reganho ponderal em pacientes pós-cirurgia bariátrica: Revisão Integrativa
Authors: Silva Lucas Hildebrando Sales , Paes Nathalia Comassetto , Brandão Yuri Silva Toledo , Souza Allan Maia Andrade de , Coelho Jorge Artur Peçanha de Miranda , Comassetto Isabel , Gonçalves Andrelina Melo de Lima , Nascimento Gian Carlos Rodrigues do , Malta Guilherme Oliveira de Albuquerque , Silva Raíssa Rafaella Santos Moreno da
Published: July 2022

A obesidade é uma doença crônica considerada como um dos principais problemas de saúde pública do mundo em virtude de seus prejuízos à saúde, dentre os métodos para perda de peso está a cirurgia bariátrica, contudo, apesar do sucesso do procedimento, há alta porcentagem de reganho ponderal no período posterior, impedindo o comprimento de sua meta terapêutica. Objetivo: Identificar e analisar as evidências científicas disponíveis na literatura acerca dos fatores que influem no reganho ponderal de pacientes pós cirurgia bariátrica. Metodologia: Trata-se uma pesquisa de revisão integrativa, atendendo as recomendações PRISMA e desenvolvida em seis etapas: 1) identificação do tema e formulação da questão norteadora; 2) busca na literatura; 3) categorização dos estudos; 4) avaliação dos estudos incluídos; 5) interpretação dos resultados; 6) síntese do conhecimento. A busca foi realizada nas bases de dados Pubmed; Bireme; Cochrane Library; MedLine, LILACS e SciELO. Publicados no período de março de 2016 a maio de 2022. Resultados: Foram encontrados 231.369 artigos, dos quais foram selecionados oito artigos que atenderam aos critérios estabelecidos. Os fatores identificados na literatura foram hábitos e transtornos alimentares, baixa adesão à atividade física, comportamentos e hábitos de vida, metabolismo e fatores psicológicos. Conclusão: Considera-se de extrema importância identificar os fatores que possam vir a influir no reganho ponderal pós-cirurgia bariátrica, de forma a compreender as razões por envolvidas dos desfechos desfavoráveis e alcançar um cuidado multiprofissional no combate a obesidade, cujo foco seja o paciente assistido em toda sua integralidade.
Antimalarial activities of plants with medicinal potential: a systematic review of the literature
Authors: Martinez Leandro do Nascimento , Silva Nairo Brilhante da , Silva Minelly Azevedo da , Fialho Saara Neri , Costa Joana D'Arc Neves
Published: July 2022

Objective: This is a qualitative study, whose objective was to investigate the scientific literature on plant species potentially active against Plasmodium sp. Method: This is a systematic literature review, which aimed to analyze the most recent articles published between the years 2005-2020 in the languages: English and Portuguese. The studies were chosen in an integrative way from the following databases: PubMed (National Library of Medicine), LILACS (Latin American and Caribbean Health Sciences Literature), Science Direct (Explore, scientific and medical) and SciELO (Scientific Electronic Library Online). Results and discussion: 115 species distributed in 50 botanical families were found in antiplasmodial inhibition studies, of which 66 different types of extracts showed action in eliminating these parasites, while 59 of these extracts were inactive. Of this total number, the most studied species belong to the Asteraceae and Fabaceae families. In addition, another 141 botanical species were cited in ethnobotanical surveys in different regions of the world. Aponynaceae and Lamiaceae were the most representative plant families among the studies focused on this topic. The data also allowed us to understand how popular knowledge can help to establish scientific discoveries about plants with antimalarial potential. In addition, environmental conditions were identified as determining factors for the production of chemical constituents in these plants. Conclusion: Efforts to identify plants with active potential in combating the parasite have increased significantly in recent years; however, it is important to emphasize that the preservation of biodiversity needs to be an important aspect of ethnobotanical research in order to guarantee the sustainable use of available resources.
Associação patológica e histórica entre a Síndrome de Guillain-Barré (SGB) e infecção pelo Zika Vírus
Authors: Silva João Felipe Tinto , Medeiros Felipe Lima de , Mello Emmanuella Costa de Azevedo , Sousa Emanuel Osvaldo de , Oliveira Ingrid Mikaela Moreira de , Araújo Emanueli Larice Costa , Soares Gustavo Henrique dos Santos , Lima Tuanny Beatriz dos Santos , Souza Thaís Ferreira Modesto , Leal Elayne Cristina Pereira de Souza , Leitão Darlly Tavares , Andrade Katia Helena Marinho de
Published: July 2022

Introdução: A origem da SGB ainda é desconhecida, contudo, frequentemente é precedida por uma infecção, havendo relatos da sua relação com a infecção pelo Zika Vírus. Objetivo: investigar a relação existente entre a infecção pelo Zika vírus e a Síndrome de Guillain-Barré (SGB). Método: Revisão integrativa da literatura realizada através de bases de dados indexadas na Biblioteca Virtual em Saúde (BVS), utilizando os descritores: “Infecção por Zika Vírus”, “Infecções por Arbovirus” e “Síndrome de Guillain-Barré”. Foram selecionados 06 estudos. Resultados:  Os mecanismos fisiopatológicos subjacentes da SGB ligados ao vírus de Zika são desconhecidos, embora as reações imunológicas descritas com outros micróbios patogênicos poderiam ter o mesmo papel putativo. Além disso, não há nenhuma explicação válida para a emergência desta complicação que não foi relacionada previamente ao Zika vírus. Uma teoria é que o vírus evoluiu geneticamente a um genótipo mais patogênico. Considerações Finais: É relata uma associação entre a SGB e a infecção pelo Zika vírus, existindo algumas hipóteses e estudos realizados que visam investigar a fisiopatologia envolvida nessa associação. Apesar dos estudos recentes, são necessários mais estudos para aprofundar o entendimento completo dos mecanismos envolvidos.
Nitrate availability modulates induced defenses in Phaeocystis globosa against protozoan grazers
Authors: Wang X , Yang F , Wang Y
Published: July 2022

Colony formation by Phaecoystis has been widely considered an induced defense mechanism against various grazers and contributes to the occurrence of algal blooms in nitrate-enriched waters. However, the effects of nitrate availability on these induced defenses against protozoan grazers remain unclear. Four P. globosa strains isolated from 4 off-coast areas of the South China Sea were exposed to grazing cues associated with the ciliate Euplotes vannus and the heterotrophic dinoflagellate Oxyrrhis marina under nitrate-sufficient and nitrate-deficient conditions to evaluate whether nitrate availability modulates the expression and costs of induced defenses. Except for one strain exposed to ciliate cues under nitrate-deficient conditions, all strains expressed defensive responses to grazing cues. Colony numbers consistently increased in the presence of grazing cues regardless of nitrate availability, although the amplitude of the increase was greater under nitrate-deficient conditions. Negative linear relationships were observed between colony numbers and population growth rates for 2 strains under nitrate-deficient conditions, suggesting increased energetic costs of defenses. The other 2 strains that did not exhibit negative relationships between colony numbers and growth nevertheless exhibited decreased cellular particulate organic carbon, particulate organic nitrogen, and chlorophyll a content in addition to smaller cellular diameters, suggesting that P. globosa can save energetic costs by adjusting physiological processes and cell sizes. These results suggest that nitrate availability strongly modulates the expression of induced grazing defenses and substantially influences the partitioning of cells into colonial or solitary forms in Phaeocystis, thereby also modulating their ecological roles in local food webs.
Estimating Pacific walrus abundance and survival with multievent mark-recapture models
Authors: Beatty WS , Lemons PR , Everett JP , Lewis CJ , Taylor RL , Lynn RJ , Sethi SA , Quakenbush L , Citta JJ , Kissling ML , Kryukova N , Wenburg JK
Published: July 2022

Arctic marine ecosystems are undergoing rapid physical and biological change associated with climate warming and loss of sea ice. Sea ice loss will impact many species through altered spatial and temporal availability of resources. In the Bering and Chukchi Seas, the Pacific walrus Odobenus rosmarus divergens is one species that could be impacted by rapid environmental change, and thus, population assessments are needed to monitor changes in the status of this ecologically and culturally important marine mammal. We conducted a 5 yr genetic mark-recapture study to estimate demographic parameters for the Pacific walrus. We developed a Bayesian multievent mark-recapture model to estimate walrus survival and abundance while accounting for age misclassification. We estimated the probability of juvenile annual survival as 0.63 (95% credible interval [CrI]: 0.39-0.87) and adult female annual survival as 0.90 (95% CrI: 0.74-1.00). We estimated total abundance as 256434 (95% CrI: 171047-364659). We provide the first estimate of total Pacific walrus abundance since an aerial survey in 2006, which generated a substantially less precise total population size estimate (129000; 95% CI: 55000-507000). The emerging ecosystem state in the northern Bering and Chukchi Seas will likely result in a decline in Pacific walrus abundance, but there is substantial uncertainty regarding the magnitude of the anticipated decline. Our demographic estimates provide critical information to evaluate future population trends of this subsistence resource vital to communities that border the Bering and Chukchi Seas in the USA and Russia.
A Case Study on Cultural Self-consciousness Education for Pre-service Korean Language Teachers: Focusing on Identity
Authors:   The Korean Society of Culture and Convergence, Park Soyeon
Published: July 2022

This study theoretically considered the identity in terms of 'cultural self-awareness education' in order to cultivate the intercultural communication ability of prospective Korean language teachers. Based on this, as a reflective approach to identity, it was intended to seek specific and practical educational measures for mutual culture awareness. To this end, the concept definition and type of identity were examined. In addition, the correlation between the characteristics of identity, language and identity, and intercultural communication and identity was confirmed. Through this, the plurality, relativity, dynamics, and variability of identity were confirmed. In addition, the characteristics of social identities that act as cultural components were reviewed. In addition, based on the fact that personal identity and social identity appear simultaneously in individual speech, the necessity and importance of considering identity in intercultural communication situations were confirmed. This study specifically presented cultural self-awareness education plans for prospective Korean teachers, which were rarely covered in previous studies, in terms of identity. In addition, there is a difference in that the effect was confirmed based on the actual class case. In particular, it is significant in that reflection on identity is not limited to the theoretical aspect but sought to improve communication skills between cultures in a practical sense.
A Study on The Development of Regular Curriculum-based Class and the Analysis of Academic Achievement for College Students on Academic Probation
Authors:   The Korean Society of Culture and Convergence, Won Serim , Choi Jiyeon
Published: July 2022

This study is to develop the academic strategic class in curriculum-based and analyse the change of academic achievement for the students placed under two times academic probation. This academic strategic class is that the students with two times academic probation are obligatory to participate in the class and take the grade. The academic strategic class is consisted of 15 weeks in regular semester. The students of this class are encouraged to have the interest in academic life and motivate to learn. Therefore, the basic purpose of this class is to prevent students form dropout college. The class was conducted among 62 the students placed under academic probation and the grade, credits and the escaping ratio from the bachelor’s warning was analysed comparing to previous semester’s. The results of the study are as follows. First, the academic strategic class for students on academic probation was designed and developed in regular curriculum-based. The developed class was provided for students on academic probation during 15 weeks with detailed subject. Second, the grade and credits of all the students on academic probation was improved comparing to previous semester’s. Third, 49 out of 62 the students(about 79.03%) placed under academic probation escaped from the bachelor’s warning. Based on the results of these researches, I would like to give some specific suggestions about academic strategic class that operate under the bachelor’s warning system in the university.
A Study on Improvisation Techniques Appearing in Keith Jarrett 《Koln Concert January 24, 1975, Pt. A》
Authors:   The Korean Society of Culture and Convergence, Kim Sujin , Jeon Yoonhan
Published: July 2022

This paper focuses on the characteristics of improvisation among the various musical expression techniques of Keith Jarrett. The field of improvisation, which originated from the European classical tradition, is one of the ever-developing techniques in music history. Used as a tool to show the performer’s technical excellence by the musical styles of many eras, improvisation has been independent of musical structure since the 1960s, and has everything from creation to rhythm to form. It was a new concept that the performer’s will was reflected as it was. This is the 1960s free jazz and 1970s fusion jazz era. This paper focuses on the improvisational form of fusion jazz, and while the style of one’s own is firmly established through the flow of this era, the live performance of artist Keith Jarrett who expresses the improvisational performance of infinite possibilities. I mainly researched Part. II A in the concert album “Koln Concert”. As a result, improvisation is part of the art that goes out of the unconscious, but by no means easy to define. It can be said that it is a noble product of continuous training by researching and repeat over and over again music techniques that human beings have made or can make for each era, involving music from the time it was born to modern music. Through this paper, I emphasize that expressing the overall things that the performer has, such as values, emotions, and philosophies, as well as the latent musicality, is the most important part of improvisation.
A Study on the Structural Relationship between COVID-19 and the Pandemic University Lifelong Education Intention to Continue Learning
Authors:   The Korean Society of Culture and Convergence, Kim Jaekum
Published: July 2022

This study clarified the structural relationship between the quality of non-face-to-face lecture quality, learning immersion, learning satisfaction, and learning continuation intention of university lifelong education adult learners. The results of an online survey of 358 adult learners of lifelong education in Seoul and Gyeonggi-do universities are as follows. First, educational service quality tangibility and empathy had a positive effect on flow, and the influence of tangibility was relatively large. Second, all five factors of educational service quality, tangibility, reliability, responsiveness, certainty, and empathy, had a positive effect on learning satisfaction, but tangibility had a negative effect. Third, between learning flow and learning satisfaction and continuous participation intention, learning satisfaction was found to have an effect on learning flow and continuous participation intention, and learning flow also had an effect on continuous participation intention. Finally, as a result of the mediating effect of university learning flow, a partial mediating effect existed between learning satisfaction and continued participation intention. This study is expected to be generalized as basic data in the establishment of strategies and operation of non-face-to-face lectures for liberal arts for adult learners of lifelong education at university.
A Study on the Selection of Neologism for Professionals and Learning in Advanced Korean: Focusing on the “social” Theme Field
Authors:   The Korean Society of Culture and Convergence, Kang Sujin , Lee Junghyun
Published: July 2022

The purpose of this study is to select and suggest neologism for teaching and learning for advanced Korean learners. For this purpose, 1,040 Neologisms in the topic area of “society” were extracted from the Newly-coined word sourcebook and analyzed how continuously they have been used for 10 years from 2009 to 2019 using the news big data analysis system BIGKINDS. Based on this analysis criteria of this study, 60 neologism were finally selected for teaching and learning. Furthermore, we analyzed the social factors that influenced these retention and the use cases. At the time, the group was divided into four categories: “neologism showing an increasing phase”, “neologism showing a decreasing phase”, “neologism showing high usage at a certain period” and “neologism that is used steadily”. This analysis is significant in that it extracted the neologism needed at the Korean language education field from the Newlycoined words sourcebook published by the prestigious National Institute of Korean Studies and analyzed examples sentence and social cause to supporting this. The Neologism proposed in this study can be used as basic materials in the field of education in that they are analyzed by finding and analyzing the background of the neologism and the possibility of future use.
University Writing Education Plan Based on Flipped Learning: Focusing on the Case of A University in Gyeongbuk
Authors:   The Korean Society of Culture and Convergence, Kim Yeonju
Published: July 2022

This study intends to introduce the operation process of a writing class through flipped learning in a real-time online classroom. I would like to recommend flipped learning as a way to overcome the limitations of existing writing education through real examples. The flipped-learning method operated by the writing class at A University in Gyeongbuk can serve as a starting point for various alternative configurations that can supplement offline lectures. This thesis focused on how the flipped-learning-based writing class could be realized in a new, non-face-to-face online environment, paying attention to the positive effects of flipped learning. In particular, this study intends to confirm the usefulness of flipped learning in a non-face-toface situation triggered by a pandemic. The purpose of this study was to determine whether flipped learning is a means to promote participation and dialogue in learners who have difficulties in interaction. As a result, it was confirmed that flipped learning can contribute to some extent in enhancing and reinforcing learners’ sense of presence and interaction in proportion to the learner’s activity. Of course, flipped-learning cannot be idealized as the sole criterion for a writing class. This is because a writing classroom based on flipped-learning presupposes the activeness of learners who have acquired a certain knowledge of writing. And such active dialogue and participation are necessary parts even in the offline classroom. In the end, the instructor is inevitably faced with the problem of how to elicit the ‘learner’s activity’. This is a task that learners and instructors must solve together as members of the learning community. More diverse methods to create an organic interaction model of online and offline classes should be continuously tested.
Study on the Subject of Animation through Semiotic Analysis  Created by Sylvain Chomet
Authors:   The Korean Society of Culture and Convergence, Kim Sungeun
Published: July 2022

The most of the scenes in  created by Sylvain Chomet is without dialogue and they convey a story through images. This work used advantage of animation to show characters, backgrounds, and situations. Most of the people living in Belleville are overweight and walking with a waddling gait, and there is a character that reminds us of Mickey Mouse. The triplets barely make a living by eating mutant frogs in polluted waters, and there is filled with images that seem to have some meaning, such as the fat Statue of Liberty holding a hamburger in Belleville. Although this work shows a simple heroic narrative structure in which a grandmother who is the main character rescues her grandson kidnapped by the mafia with triplets, the outstanding images make us consider many things deeper rather than just a confrontation between good and evil, or didactic contents. This study analyzes the theme of  using Actantial model of Greimass and semiotic rectangle as analysis tools. It is hoped that this paper is helpful for those who are curious to know about the meaning of the work, which has many meanings with unique images.
Wagner as the Phenomenon and the De-politicization of Music: On Its Own Possibilities and Limitations
Authors:   The Korean Society of Culture and Convergence, Chung Woojin
Published: July 2022

The primary purpose of this study is to consider critically how to make an appropriate response to Richard Wagner as the phenomenon (and his music) in which many different, heterogeneous, sometimes contradictory aspects find so entangled as not to be able to pull them apart and to suggest an answer in its own. For this, the first thing we should do is to make clear it to be meant by the phenomenon of Wagner. As the discussion goes on, it is expected that the attempt called the de-politicization of music as a kind of strategy for rescuing the composer from his anti-Semitism or the abuse by Hitler and Nazi disclose its own possibilites and limitations. The study begins with taking a look into the reason why so many people in almost every areas continue to argue pro and contra Wagner and then in particular why Thomas Mann has been shivered with the music of Wagner twice, reflecting to himself and contemplating on Wagner’s music regarded as the quintessence of the ‘German’ in order to single out the nub of the phenomenon Wagner. Built upon this, it demonstrates that the de-politicization of music based on the aesthetic autonomy is necessary for the relevant reception of the phenomenon of Wagner by examining in detail the (ideologically) incompatible interpretations of Parsifal, Wagner’s last Musikdrama, especially its conclusion. Still, for the purpose of inquiring into the limitations involved in the ‘de-politicization of music’ the study carry out the comparison of the synaesthetic effect aroused by Wagner’s music with the so-called plugging effect in reference to the mechanism in cultural industry, resulting in the emphasis on the necessity or inevitability of a critical way of responding to the Wagner phenomenon.
International Chinese Students’Perception of Korean as a Medium of Instruction in a Korean University: Focusing on the Case of W University
Authors:   The Korean Society of Culture and Convergence, Li Yue , Lee Yongjik
Published: July 2022

This study explores international Chinese students’ experiences of Korean as a Medium of Instruction (KMI) course in a Korean university. This study focuses on the KMI course that allows students to simultaneously learn Korean academic language and content knowledge. Thus, this study examines the effectiveness of the KMI course for Chinese international students and proposes effective teaching methods that will enable international students to perform academic studies in the future successfully. This study is conducted at the graduate school of W University in Korea. The KMI method is applied to two graduate courses with 15 Chinese international students during the 2021 Fall semester. By using mixed-method, the survey is conducted to determine the perception and satisfaction of the international Chinese students’ experiences in the KMI course related to content knowledge, cognitive ability, and multicultural understanding. Among survey participants, interview applicants are selected and conducted in-depth interviews. The results as shown below. First, Chinese international students develop various content knowledge through the KMI course. Second, Chinese international students can improve their Korean language ability through the KMI course. Third, bilingual KMI courses are more effective in learning Korean vocabulary and grammar than monolingual KMI courses. Third, Chinese international students understand Korean culture and university life through the KMI course. Fourth, Chinese international students are generally satisfied with the KMI course. However, Chinese international students face a challenge that quickly improves their Korean academic ability through the KMI. The conclusions as shown below. First, the KMI course positively affects the content knowledge of Chinese international students. Second, the KMI course has a positive effect on improving the Korean ability of Chinese international students. Third, the KMI course positively affects international students’ understanding of multiculturalism. However, the KMI course may not dramatically impact international students’ academic Korean language skills in a short period.
Visual Metaphor Applied to the ‘Portrait’ of SARS-CoV-2: Focusing on Illustrations and Electron Microscope Photos
Authors:   The Korean Society of Culture and Convergence, Kim Hoongi
Published: July 2022

The purpose of this paper is to compare and examine the metaphorical expressions in the visual materials of SARS-CoV-2. The subjects of this study are two illustrations by the US CDC and a researcher David S. Goodsell, and two electronic microscope photos by the US NIAID and Austrian company Nanographics. The metaphorical expressions and meanings were examined in terms of ‘superimposition (transformation, deletion, addition)’ and ‘replacement.’ The first illustration applied superimposition method such as transformation into a full sphere, omission of the number of M proteins, addition of red color to the S protein, and used replacement method treating the background as a black space. The second illustration used superimposition method such as simplifying the end of the S protein, adding various colors, and replacement method describing the background as a space filled with fancy colors. The first photo of the electron microscope applied superimposition and replacement methods by treating various colors on the scenes of viruses and surrounding components. In comparison, the second photo added only minimal colors to show the most realistic appearance, but the background of the black space left the impression of the virus as a fearful object. Identifying the metaphorical devices can contribute to the improvement of visual literacy by critical thinking ability about SARS-CoV-2.
A Study on the Campus Life Experience of Students with Late School Disabilities in the Educational Environment of Covid-19
Authors:   The Korean Society of Culture and Convergence, Kim Junghyun
Published: July 2022

This study intends to examine the lives and the adaptation processes of students with late school disabilities, which consists of the face-to-face and non-face-to-face learning methods under the Covid-19 pandemic and analyzes the changes in their past and present lives through the university classes and learning experiences. Seven students with late school disabilities were sampled through the snowball method, and the data were analyzed through Van Manen method, one of the phenomenological methodologies. Five essential themes were derived from the campus life experiences of students with late school disabilities describing as “repeated daily life in the corona pandemic and opposition from surrounding”, “educational environment unfamiliar than expected”, “un-narrowed Digital Gap”, “pleasure from learning”, and “rediscovery of the self that he can do”. The said five essential themes can be understood as a process of “finding the joy of learning and regaining confidence in life”, however, which can also be summarized as “a change that is being recognized” through the analysis of the non-contact campus life experiences of the student with late school disabilities. Although there are still inconveniences in non-face-to-face campus life, it can be understood as a changing process of discovering themselves positively in an unfamiliar nonface- to-face educational environment. Their campus experiences can be described as follows; first of all, it appeared as an irregular, dreary, lonely lives in which there is freedom, but taking responsibilities for it. Through a comfortable home, friends, and living in a comfortable environment, which brought satisfaction in their lives and positive perception as independent students. Not only that, but it appeared as a process of finding the role for the disabled. This can be understood as having hopes and dreams for the future as the mind and life that were anxious about specific goals and dreams were stabilized, dreams and small hopes for the future and the attitude toward life changes. In the campus life experiences of students with late school disabilities, it was confirmed that the study participants independently changed toward their independent life satisfaction and positive perception of themselves as a process of change in which the self-determination rights and goals and hopes for their lives by seeking the role for the disabled who have not yet been encountered and in the process of positively recognizing themselves.
Mediating Effect of Technological Self-Efficacy on Elementary School Students’ GRIT, Online Learning Satisfaction, and Transfer of Learning
Authors:   The Korean Society of Culture and Convergence, Woo Chaeyoung , Park Jeongsoon
Published: July 2022

This study was conducted to investigate the correlation between technological self-efficacy and GRIT, online learning satisfaction, and transfer of learning perceived by among elementary school students. It also aimed to verify the mediating effect of technological self-efficacy. To this end, a survey was conducted on 300 elementary school students. The collected data was analyzed using the SPSS 28.0 and SPSS Process Macro 4.1 program. The results were as follows; first, persistence in student effort showed a positive correlation with persisted interest, technological self-efficacy, online learning satisfaction, and transfer of online learning. In particular, online learning satisfaction and transfer of learning showed the highest positive correlation. Second, among the sub-factors of GRIT, the mediating effect of technological self-efficacy on persistant effort, online learning satisfaction, and transfer of learning was verified. These results imply that GRIT(perseverance of effort), belief in technology, and learning satisfaction are factors that can lead to a positive effect in online learning. It suggests that a strategy to promote these factors is required. This study is significant in that it verified the factors for enhancing the effectiveness of online learning in elementary schools.
Thermoelectric Performance of Sn and Bi Double-Doped Permingeatite
Authors: Ahn Hee-Jae , Kim Il-Ho
Published: July 2022

In this study, mechanical alloying was performed to synthesize permingeatite Cu3Sb1-x-ySnxBiySe4 (0.02 ≤ x ≤ 0.06 and 0.02 ≤ y ≤ 0.04) doped with Sn and Bi. Hot pressing was subsequently conducted to achieve dense sintered bodies. When the Bi content was constant, the carrier concentration increased with the Sn content, but the mobility decreased owing to the increased carrier concentration. In contrast, when the Sn content was constant, the carrier concentration and mobility were not significantly affected by the Bi content. Higher electrical conductivity was observed in specimens with a higher Sn content or lower Bi content; consequently, Cu3Sb0.92Sn0.06Bi0.02Se4 exhibited the highest electrical conductivity. The Seebeck coefficient increased with temperature, and it is inferred that the permingeatite doped with Sn/Bi does not undergo an intrinsic transition until 623 K. In contrast to the electrical conductivity, a higher Seebeck coefficient was obtained in the specimens with a lower Sn content or higher Bi content; consequently, Cu3Sb0.94Sn0.02Bi0.04Se4 exhibited the highest Seebeck coefficient. Cu3Sb0.92Sn0.06Bi0.02Se4 exhibited the maximum power factor, depending on the electrical conductivity and Seebeck coefficient. The electronic thermal conductivity was not significantly affected by temperature, but the lattice thermal conductivity decreased as the temperature increased. However, the thermal conductivity decreased with increasing temperature. Sn doping effectively reduced the lattice thermal conductivity, whereas Bi doping effectively reduced the electronic thermal conductivity; consequently, Cu3Sb0.94Sn0.02Bi0.04Se4 exhibited the lowest thermal conductivity. Finally, the highest dimensionless figure-of-merit of 0.75 was achieved at 623 K by Cu3Sb0.92Sn0.06Bi0.02Se4.
ANALYSIS OF FACTORS AFFECTING AUDITOR SWITCHING IN INDONESIA
Authors: Wage Sunarto , Harry Mardika Nanda
Published: July 2022

This study's goal is to ascertain the impact of The goal of this study is to identify the factors that affect auditor turnover, including auditor opinion, financial distress, client business growth, and KAP size. The LQ 45 index businesses listed on the Indonesian Stock Exchange for the years 2018 through 2021 made up the study's population. 15 businesses were chosen as a sample using the purposive sampling method. Using Software Reviews, analyze survey data using multiple linear regression analysis 9. The findings of this study indicate that auditors' ability to move firms is influenced by audit opinion and margin size. At the same time, the turnover of auditors is unaffected by client firm development and financial difficulty.
Telemedicine: Benefits for Cardiovascular Patients in the COVID-19 Era
Authors: Ghilencea Liviu-Nicolae , Chiru Maria-Roxana , Stolcova Miroslava , Spiridon Gabriel , Manea Laura-Maria , Stănescu Ana-Maria Alexandra , Bokhari Awais , Kilic Ismail Dogu , Secco Gioel Gabriel , Foin Nicolas , Di Mario Carlo
Published: July 2022

The recent pandemic with SARS-CoV-2 raises questions worldwide regarding telemedicine for housebound patients, including those with cardiovascular conditions. The need for further investigation, monitoring and therapeutic management are advancing practical issues which had not been identified for consideration prior to the pandemic. Using the marketing assessment, we identified the needs of the patients and evaluated the future steps necessary in the short term to meet them. The research found progress made via telemedicine in monitoring and conducting minor decisions (like up-titrating the doses of different medication regimens) in patients with several cardiovascular diseases (heart failure, atrial fibrillation, high blood pressure), as there is a worldwide trend to develop new telemonitoring biosensors and devices based on implantable delivered transcatheter. The worldwide telemedicine trend encourages a switch from small and hesitating steps to a more consistent assessment of the patients, based on high technology and Interventional Cardiology. Cardiovascular telemedicine, although made a sustainable effort in managing patients' health, has many obstacles to overcome before meeting all their needs. Data security, confidentiality and reimbursement are the top priorities in developing remote Cardiology. The regulatory institutions need to play an integrative role in leading the way for defining the framework of future telemedicine activities. The SARS-CoV-2 outbreak with all its tragedy served to reinforce the message that telemedicine services can be life-saving for cardiovascular patients. Once the Covid-19 era will fade away, telemedicine is likely to remain a complementary service of standard care. There is still room to improve the remote identification and investigation of heart disease, provide an accurate diagnosis and therapeutic regimen, and update regulations and guidelines to the new realities of technological progress in the field.
Association of Serum Bilirubin With Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Authors: Liang Chen , Yu Zhiyuan , Bai Li , Hou Wei , Tang Shan , Zhang Wei , Chen Xinyue , Hu Zhongjie , Duan Zhongping , Zheng Sujun
Published: July 2022

Objective

Metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) are the leading chronic diseases worldwide. There are still many controversies about the association between serum bilirubin and MetS or NAFLD. This study aims to evaluate the association of serum total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL) with MetS and NAFLD.

Methods

Multiple databases were searched for relevant studies until November 2021. Randomized controlled trials, cross-sectional and cohort studies evaluating the association between serum bilirubin levels and MetS or NAFLD were included.

Results

Twenty-four cross-sectional and cohort studies with 101, 517 participants were finally analyzed. Fifteen studies and 6 studies evaluated the association between bilirubin and MetS or NAFLD in health screening population, respectively, while 3 studies evaluated the association between bilirubin and non-alcoholic steatohepatitis (NASH) in NAFLD patients. Random effect model analysis showed the inverse association between TBIL and MetS in male (95%CI=0.71-0.96) and gender-neutral (95%CI=0.61-0.91) group. However, no significant association was found in females. Notably, the inverse association between DBIL and MetS was noticed in male (95%CI=0.36-0.75), female (95%CI=0.16-0.58) and gender-neutral population (95%CI=0.67-0.92). IBIL level was inversely associated with MetS in females (95%CI=0.52-0.96), whereas no statistical correlation presented in males. TBIL was not statistically correlated with NAFLD in gender-neutral or male subgroup. Similarly, there were no association between DBIL or IBIL and NAFLD in gender-neutral subgroup. However, the negative correlation between DBIL and NAFLD existed in males (95%CI=0.76-0.96). In NAFLD patients, IBIL analysis showed an inverse association with NASH (95%CI=0.01-0.12).

Conclusion

Serum TBIL and DBIL levels, especially DBIL levels, assume an inverse correlation with MetS in healthy population. Serum IBIL is inversely associated with the onset and degree of NASH in NAFLD patients. Exogenous bilirubin supplement may be a potential strategy to assist in lowering the risk of developing MetS and NAFLD.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42021293349
The Role of AIF-1 in the Aldosterone-Induced Vascular Calcification Related to Chronic Kidney Disease: Evidence From Mice Model and Cell Co-Culture Model
Authors: Chang Xueying , Hao Jianbing , Wang Xingzhi , Liu Jingwei , Ni Jie , Hao Lirong
Published: July 2022

Increasing evidence suggests that aldosterone (Aldo) plays an essential role in vascular calcification which is a serious threat to cardiovascular disease (CVD) developed from chronic kidney disease (CKD). However, the exact pathogenesis of vascular calcification is still unclear. First, we established CKD-associated vascular calcification mice model and knockout mice model to investigate the causal relationship between allograft inflammatory factor 1 (AIF-1) and vascular calcification. Then, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) co-culture experiments were performed to further explore the mechanisms of calcification. The results of the Aldo intervention mice model and transgenic mice model showed that Aldo could cause calcification by increasing the AIF-1 level. The results of in vitro co-culture model of ECs and VSMCs showed that AIF-1 silence in ECs may alleviate Aldo-induced calcification of VSMCs. In conclusion, our study indicated that Aldo may induce vascular calcification related to chronic renal failure via the AIF-1 pathway which may provide a potential therapeutic target.
Immune Evasion and Drug Resistance Mediated by USP22 in Cancer: Novel Targets and Mechanisms
Authors: Guo Jinhui , Zhao Jie , Fu Wen , Xu Qiuran , Huang Dongsheng
Published: July 2022

Regulation of ubiquitination is involved in various processes in cancer occurrence and development, including cell cycle arrest, cell proliferation, apoptosis, invasion, metastasis, and immunity. Ubiquitination plays an important role not only at the transcriptional and post-translational levels but also at the protein level. When ubiquitination is in a pathological state, abnormally activated biological processes will not only induce cancer progression but also induce immune evasion. The main function of deubiquitinases (DUBs) is to remove ubiquitin chains from substrates, changing the biological activity of the substrates. It has great potential to improve the prognosis of cancer by targeting DUB to regulate proteome. Ubiquitin-specific peptidase 22 (USP22) belongs to the ubiquitin-specific protease (USP) family of DUBs and has been reported to be related to various physiological and pathological processes. USP22 is abnormally expressed in various malignant tumors such as prostate cancer, lung cancer, liver cancer, and colorectal cancer, which suggests that USP22 may play an important role in tumors. USP22 may stabilize programmed death ligand 1 (PD-L1) by deubiquitination while also regulating T-cell infiltration into tumors. Regulatory T cells (Tregs) are a unique class of immunosuppressive CD4+ T cells that primarily suppress the immune system by expressing the master transcription factor forkhead box protein 3 (FOXP3). USP22 was found to be a positive regulator of stable FOXP3 expression. Treg-specific ablation of USP22 leads to reduced tumor volume in multiple cancer models. This suggests that USP22 may regulate tumor resistance to immunotherapy. In this article, we review and summarize the biological functions of USP22 in multiple signal transduction pathways during tumorigenesis, immune evasion, and drug resistance. Furthermore, we propose a new possibility of combining USP22 with chemotherapeutic, targeted, and immunosuppressive drugs in the treatment of cancer.