bluuebunny/crossref_metadata_2025 huggingface dataset:
Substitution of sesame and peanut defatted-meal milk with egg yolk and evaluation of the rheological and microstructural properties of low-cholesterol mayonnaise
Authors: Karshenas Mahsa , Goli Mohammad , Zamindar Nafiseh
Published: June 2019

Peanut, sesame, and (peanut:sesame (1:1)) meal milk were used as the egg yolk substitute at the levels of 0%, 25%, 50%, 75%, and 100% in mayonnaise. Then, the rheological, textural (hardness, adhesive force, and adhesiveness), and microstructural properties of samples were evaluated on the first day after production. The oscillatory test indicated that all treatments had shear thinning flow behavior and in low-angular frequencies had higher elastic modulus than the viscous modulus (tan δ < 1), but in the P-S50 and P-S100, P75 and S75 in angular frequencies higher than 63 rad.s−1, tan δ was more than one (i.e. G″ > G′) which indicated more viscous modulus (liquid-like flow behavior) than the elastic modulus (gel-like flow behavior). The optical microscopy confirmed that the oil particle size in blank, 25 and 50% of substitution was of smaller size, and the fat droplets had a monotonous and regular form. In 75 and 100% of substitution, the oil particle size was larger and more irregular than the other ones. Therefore, considering the emulsifying characteristic of oilseeds proteins, consumer health aspect (replacing meal protein with egg yolk in producing of low-cholesterol mayonnaise), and economic advantage aspect (reusing the oil-extraction factories by-products i.e., meal) using oilseed meal milk as an emulsifier agent in food industries especially emulsions is purposed.
Online patient feedback: a cross-sectional survey of the attitudes and experiences of United Kingdom health care professionals
Authors: Atherton Helen , Fleming Joanna , Williams Veronika , Powell John
Published: June 2019

Objectives

Online patient feedback is a growing phenomenon but little is known about health professional attitudes and behaviours in relation to it. We aimed to identify the characteristics, attitudes and self-reported behaviours and experiences of doctors and nurses towards online feedback from their patients or their carers.

Methods

We conducted a cross-sectional self-completed online questionnaire of 1001 registered doctors and 749 nurses and midwives involved in direct patient care in the United Kingdom.

Results

Just over a quarter (27.7% or 277/1001) of doctors and 21% (157/749) of nurses were aware that patients/carers had provided online feedback about an episode of care in which they were involved, and 20.5% (205/1001) of doctors and 11.1% (83/749) of nurses had experienced online feedback about them as an individual practitioner. Feedback on reviews/ratings sites was seen as more useful than social media feedback to help improve services. Both types of feedback were more likely to be seen as useful by nurses compared with doctors and by hospital-based professionals compared with those based in community settings. Doctors were more likely than nurses to believe that online feedback is unrepresentative and generally negative in tone. The majority of respondents had never encouraged patients/carers to leave online feedback.

Conclusions

Despite enthusiasm from health policymakers, many health care professionals have little direct experience of online feedback, and rarely encourage it, as they view it as unrepresentative and with limited value for improving the quality of health services. The difference in opinion between doctors and nurses has the potential to disrupt any use of online patient feedback. The findings have implications for policy and practice in how online patient feedback is solicited and acted upon.
Max Weber’s concept of ‘modern politics’
Authors: Fitzi Gregor
Published: June 2019

In a critical approach to Mommsen’s classical thesis, which states the dependence of Weber’s sociology on his political position, the article reconstructs the foundation of Weber’s ‘The Profession and Vocation of Politics’ on his sociological analyses of the political domain in the manuscripts for the posthumous publication of Economy and Society. The first two pages of his 1919 lecture particularly show that Weber can fall back on the definitions of State and politics that he had already developed for his political sociology. Yet, to appreciate the full extent of this theoretical contribution, it is necessary to present Weber’s entire ideal-typical analysis of the political. The article then shows that Weber provides an unlabelled definition of ‘modern politics’ that negates ante litteram Carl Schmitt’s foundation of politics on the idea of enmity. In this context, Weber’s sound plea for parliamentarism and against the fascination of civil war comes to the fore that he wanted to deliver to his audience of young revolutionaries in January 1919.
Experimental characterization of noise radiation from a ducted propeller of an unmanned aerial vehicle
Authors: Malgoezar Anwar MN , Vieira Ana , Snellen Mirjam , Simons Dick G , Veldhuis Leo LM
Published: June 2019

Ducted propellers are an interesting design choice for unmanned aerial vehicle (UAV) concepts due to a potential increase of the propeller efficiency. In such designs, it is commonly assumed that introducing the duct also results in an overall noise reduction. The objective of this work is to experimentally analyze and quantify noise of a ducted propeller suitable to be installed on a medium size UAV (wingspan 5–10 m). A microphone array is used for recording the noise levels at each microphone position and used collectively to localize noise sources with beamforming. Different types of noise sources are considered (an omni-directional source and a propeller). In addition, the effect of the presence of an incoming airflow is assessed. With no incoming airflow, it is found that the duct significantly modifies the noise radiation both in the frequency and the spatial domain. With an incoming airflow, the effect of the duct on the frequency content of the signal is almost eliminated. The fact that for this case the harmonics become lower results in a reduction of the received noise levels. Also the directivity changes. These insights are of importance in efforts towards modeling the effects of ducts for complex noise sources such as propellers.
Upper limb vascular mapping with Doppler ultrasound: Technique precision evaluated in healthy volunteers
Authors: Germano Ana S , Gomes António P , Martins Rita , Sousa Marta , Nunes Vitor
Published: June 2019

Introduction

Doppler ultrasound is recommended by international societies for preoperative vascular mapping in vascular access surgery. Literature is scarce regarding data on Doppler ultrasound-associated errors.

Objectives

Our aim was to evaluate Doppler ultrasound precision for upper limb vascular mapping.

Methods

Fifty-two adult healthy volunteers were evaluated for superficial vein diameter, brachial artery flow and diameter in the lower third of non-dominant arm by a dedicated vascular access radiologist blinded for the identification of the participants. Each participant was scheduled for three evaluations one week apart. Friedman test and multivariate analysis of variance for repeated measures were used.

Results

There were no statistical differences within subjects across the three weeks except for brachial artery flow in participants who had basilic vein as the dominant vein.

Discussion

Repeated anatomical and haemodynamic parameters measured by Doppler ultrasound performed by an experienced medical sonographer, according to our protocol, did not show statistical differences within subjects, independently of age, gender and body mass index.
The effect of cup orientation on stability of trapeziometacarpal total joint arthroplasty: a biomechanical cadaver study
Authors: Brauns Annelien , Caekebeke Pieter , Duerinckx Joris
Published: June 2019

It has been suggested that the cup of a trapeziometacarpal total joint replacement should be positioned parallel with the proximal articular surface of the trapezium to align it with the centre of motion. This would diminish the chance of dislocation. The goal of this study was to test this idea biomechanically. A linked trapeziometacarpal prosthesis was implanted in seven cadaver hands and combined with three-dimensional printed trapezium cups in 17 different orientations. For every combination, stability of the prosthesis was assessed through its entire passive range of motion. Dorsal inclination of the cup relative to the proximal articular surface increased the risk of dislocation with thumb flexion and opposition. The risk of dislocation was also increased with lateral or medial inclination of the cup exceeding 20°. Our results demonstrate that cup orientation is an important factor in prosthetic joint stability. Cup placement parallel to the proximal articular surface is ideal.
The effectiveness of an emotion-focused educational programme in reducing diabetes distress in adults with type 2 diabetes mellitus at 12-month follow-up: a cluster randomized controlled trial
Authors: Chew Boon-How , Vos Rimke C. , Fernandez Aaron , Shariff Ghazali Sazlina , Shamsuddin Nurainul Hana , Ismail Mastura , Rutten Guy E.H.M.
Published: June 2019

Background:

Diabetes distress (DD) is an increasingly important part of clinical medicine, diabetes self-management and research topic in people with diabetes mellitus. The present study evaluated the effectiveness of a value-based emotion-focused educational program in Malay adults with type 2 diabetes (VEMOFIT) at 12-month follow-up compared with a program with systematic attention to participants’ emotions (attention-control).

Methods:

VEMOFIT consisted of four biweekly group sessions and a booster session after 3 months; the attention-control program consisted of three sessions over the same period. Intention-to-treat analysis with multilevel mixed modelling was done to estimate the intervention effect.

Results:

Participants ( n = 124) randomized to VEMOFIT ( n = 53) or attention-control ( n = 71). Mean (SD) age 55.7 (9.7) years, median diabetes duration 7.0 (8.0) years and mean HbA1c level 9.7% (82 mmol/mol). The mean DD (DDS-17 scale) level decreased in both groups (from 3.4 to 3.3 versus 3.1–2.5, respectively), significantly more in the attention-control group [adjusted difference −0.6, 95% confidence interval (CI) −1.1, −0.2]. The VEMOFIT group had a significant improvement in self-efficacy (DMSES, range 0–200; adjusted difference 16.4, 99.4% CI 1.9, 30.9). Other outcomes did not differ.

Conclusions:

Because the attention-control program resulted in a decreased DD 1 year later, its implementation on a larger scale seems justified.

Trial registration:

NCT02730078; NMRR-15-1144-24803
ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model
Authors: Chiang Chi-Ling , Goswami Swagata , Frissora Frank W. , Xie Zhiliang , Yan Pearlly S. , Bundschuh Ralf , Walker Logan A. , Huang Xiaomeng , Mani Rajeswaran , Mo Xiaokui M. , Baskar Sivasubramanian , Rader Christoph , Phelps Mitch A. , Marcucci Guido , Byrd John C. , Lee L. James , Muthusamy Natarajan
Published: June 2019

Chronic lymphocytic leukemia (CLL) occurs in 2 major forms: aggressive and indolent. Low miR-29b expression in aggressive CLL is associated with poor prognosis. Indiscriminate miR-29b overexpression in the B-lineage of mice causes aberrance, thus warranting the need for selective introduction of miR-29b into B-CLL cells for therapeutic benefit. The oncofetal antigen receptor tyrosine kinase orphan receptor 1 (ROR1) is expressed on malignant B-CLL cells, but not normal B cells, encouraging us with ROR1-targeted delivery for therapeutic miRs. Here, we describe targeted delivery of miR-29b to ROR1+ CLL cells leading to downregulation of DNMT1 and DNMT3A, modulation of global DNA methylation, decreased SP1, and increased p21 expression in cell lines and primary CLL cells in vitro. Furthermore, using an Eμ-TCL1 mouse model expressing human ROR1, we report the therapeutic benefit of enhanced survival via cellular reprograming by downregulation of DNMT1 and DNMT3A in vivo. Gene expression profiling of engrafted murine leukemia identified reprogramming of cell cycle regulators with decreased SP1 and increased p21 expression after targeted miR-29b treatment. This finding was confirmed by protein modulation, leading to cell cycle arrest and survival benefit in vivo. Importantly, SP1 knockdown results in p21-dependent compensation of the miR-29b effect on cell cycle arrest. These studies form a basis for leukemic cell–targeted delivery of miR-29b as a promising therapeutic approach for CLL and other ROR1+ B-cell malignancies.
Dynamic dual threshold cooperative spectrum sensing for cognitive radio under noise power uncertainty
Authors: Wan Runze , Ding Lixin , Xiong Naixue , Shu Wanneng , Yang Li
Published: June 2019

The spectrum sensing performance depends on the accuracy of the detection about whether primary users are busy or idle. Previous studies on cognitive radio spectrum sensing have shown that the cooperation between secondary users can improve their spectrum detection performance in real cognitive networks. Aiming at the problem of threshold mismatch of energy detectors under noise power uncertainty, a cooperative spectrum sensing method with dynamic dual threshold is proposed. Firstly, the utility function is defined with the objective of minimizing the error probability of spectrum sensing, and the optimum threshold of energy detector is derived. Secondly, in order to mitigate the influence derived from noise uncertainty, an effective dynamic dual threshold adjustment mechanism is presented, and the optimizing combinative fusion rule is discussed with the prerequisite of the minimum global error probability. In addition, in view of insufficient number of cognitive users whose sensing results lie in decision zones, the parameter of credibility is defined to choose the secondary users with reliable local detection for final fusion. Simulation results show that our proposed method can mitigate the influence of noise uncertainty and increase the spectrum sensing accuracy compared with other existing methods.
Trust-based recommendation systems in Internet of Things: a systematic literature review
Authors: Mohammadi Venus , Rahmani Amir Masoud , Darwesh Aso Mohammed , Sahafi Amir
Published: June 2019

Internet of Things (IoT) creates a world where smart objects and services interacting autonomously. Taking into account the dynamic-heterogeneous characteristic of interconnected devices in IoT, demand for a trust model to guarantee security, authentication, authorization, and confidentiality of connected things, regardless of their functionality, is imperative. However, as far as we know, against the centrality of trust-based recommendation mechanisms in the IoT environment, there is no ambient study for investigating its techniques. In this paper, we present a systematic literature review (SLR) of trust based IoT recommendation techniques so far. Detailed classifications based on extracted parameters as well as investigation existing techniques in three different IoT layers put forth. Moreover, the advantages, disadvantages and open issues of each approach are introduced that can expand more frontier in obtaining accurate IoT recommendation in the future.
Prognostic values and clinical implications of programmed cell death-ligand 1 (PD-L1), fork head transcription factor P-1 (FOXP-1) and signal transducer and activator of transcription-3 (STAT-3) expression in diffuse large B-cell lymphoma (DLBCL); an immunohistochemical study
Authors: Harb Ola A. , Kaf Randa Mohamed , Taha Heba F. , Ahmed Rham Z. , Mandour Doaa , Al Attar Ahmed Z. , Fathy Ayman , Almoregy Abdelwahab S. , Osman Gamal , Gertallah Loay M.
Published: June 2019

Context

PD-L1 is an inhibitory ligand that functions as an essential immune checkpoint.FOXP-1is a member of the FOXP family.STAT-3plays a critical role in regulation of cell proliferation and survival. The detailed expression of the three markers together in DLBCL tissues and their prognostic value in patients with DLBCL were not fully investigated.

Aim was to assess the expression of PD-L1,FOXP-1andSTAT-3in diffuse large B-cell lymphoma (DLBCL) and to correlate their expression with the pathological findings, prognostic parameters and clinical implications of patients.

Methods

PD-L1,FOXP-1andSTAT-3were assessed in DLBCL tissues derived from 50 patients using immunohistochemistry. Patients were followed up for 3 years for response to therapy progression, recurrence and survival.

Results

High PD-L1 expression was associated with bone marrow involvement (p = 0.004), extra-nodal involvement (p = 0.006) and advanced stage (p = 0.003). High FOXP-1 expression was associated with presence of bone marrow involvement and high risk group (p < 0.001). HighSTAT-3expression was associated with older age of the patient (p < 0.001), presence of bone marrow involvement (p = 0.002), extra-nodal involvement (p = 0.009), and high risk group (p = 0.005). High expression of PD-L1, FOXP-1 and STAT-3 was related to poor response to therapy, poor OS rate and RFS rates (p < 0.001).

Conclusion

High expression of PD-L1,FOXP-1andSTAT-3was related poor prognosis in DLBCL patients.
Dental Care in Electroplexy
Authors: Durrant B. W.
Published: June 2019

Electroplexy is widely practised and recognized as a valuable form of treatment in psychiatry. The techniques used have been studied and described, and the complications
listed in detail.
Five-Year Overall Survival for Patients With Advanced Non‒Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study
Authors: Garon Edward B. , Hellmann Matthew D. , Rizvi Naiyer A. , Carcereny Enric , Leighl Natasha B. , Ahn Myung-Ju , Eder Joseph Paul , Balmanoukian Ani S. , Aggarwal Charu , Horn Leora , Patnaik Amita , Gubens Matthew , Ramalingam Suresh S. , Felip Enriqueta , Goldman Jonathan W. , Scalzo Cathie , Jensen Erin , Kush Debra A. , Hui Rina
Published: June 2019

PURPOSE

Pembrolizumab monotherapy has demonstrated durable antitumor activity in advanced programmed death ligand 1 (PD-L1)–expressing non‒small-cell lung cancer (NSCLC). We report 5-year outcomes from the phase Ib KEYNOTE-001 study. These data provide the longest efficacy and safety follow-up for patients with NSCLC treated with pembrolizumab monotherapy.

PATIENTS AND METHODS

Eligible patients had confirmed locally advanced/metastatic NSCLC and provided a contemporaneous tumor sample for PD-L1 evaluation by immunohistochemistry using the 22C3 antibody. Patients received intravenous pembrolizumab 2 mg/kg every 3 weeks or 10 mg/kg every 2 or 3 weeks. Investigators assessed response per immune-related response criteria. The primary efficacy end point was objective response rate. Overall survival (OS) and duration of response were secondary end points.

RESULTS

We enrolled 101 treatment-naive and 449 previously treated patients. Median follow-up was 60.6 months (range, 51.8 to 77.9 months). At data cutoff—November 5, 2018—450 patients (82%) had died. Median OS was 22.3 months (95% CI, 17.1 to 32.3 months) in treatment-naive patients and 10.5 months (95% CI, 8.6 to 13.2 months) in previously treated patients. Estimated 5-year OS was 23.2% for treatment-naive patients and 15.5% for previously treated patients. In patients with a PD-L1 tumor proportion score of 50% or greater, 5-year OS was 29.6% and 25.0% in treatment-naive and previously treated patients, respectively. Compared with analysis at 3 years, only three new-onset treatment-related grade 3 adverse events occurred (hypertension, glucose intolerance, and hypersensitivity reaction, all resolved). No late-onset grade 4 or 5 treatment-related adverse events occurred.

CONCLUSION

Pembrolizumab monotherapy provided durable antitumor activity and high 5-year OS rates in patients with treatment-naive or previously treated advanced NSCLC. Of note, the 5-year OS rate exceeded 25% among patients with a PD-L1 tumor proportion score of 50% or greater. Pembrolizumab had a tolerable long-term safety profile with little evidence of late-onset or new toxicity.
Comprehensive Organizational and Methodical Approaches to Decommissioning of Radwaste Repositories
Authors: Майзик А. , Mayzik A. , Кореньков И. , Korenkov I. , Цовьянов А. , Tsoviyanov A. , Лащенова T. , Laschenova T. , Клочков В. , Klochkov V.
Published: June 2019

Purpose: Development of comprehensive organizational and methodical approaches to decommissioning of shallow radwaste (RW) repositories.

Material and methods: The following researches were conducted during assessment of radiation and hygiene situation:

- assessing the state of physical barriers of repositories (tanks) of solid and liquid RW;

- assessing radiation situation at the repository site before and after remediation;

- measuring specific activity of 90Sr and 137Cs in ground and subsurface water, core sample, soils, building structures.

Methods: on foot gamma survey; gamma-ray spectrometric measurement of radionuclides in environmental samples using a stationary spectrometer; radiochemical extraction of radionuclides and their radiometry.

Results: The surveys were performed in 2014–2016. They delivered data on gamma dose rate at the RW repository site, specific activity of 90Sr and 137Cs in ground and subsurface water, core sample, soils, building structures.

The surveys showed that content of 90Sr in subsurface water varied from 0.25 to 0.4 Bq/kg, while content of 137Cs was below the detection threshold (0.01 Bq per sample). It was founded that distribution of 90Sr and 137Cs in soil (core sample) forming the top layer of the area is highly uneven. In some cases specific activity of soil exceeded 1000 Bq/kg (C-23 well at the depth of 2.75 m and C-24 well at the depth of 5 m). In all other cases specific activity of the core sample did not exceed 10 Bq/kg, and specific activity of soil was up to 50 Bq/kg which is over background values. The ambient dose equivalent rate at the site varied from 0.1 to 0.3 µSv/h.

After remediation activities content of radionuclides in soil and subsurface water was at the levels of background values.

More than 6700 measurements were performed (more than 2400 measurements of the ambient dose equivalent rate, more than 4100 measurements of beta-contamination of work surfaces and equipment, and more than 200 measurements of specific and volumetric activity of environmental samples).

Conclusions: This work allowed to substantiate technical solutions, procedure of RW accounting and control, using of shelters and mobile systems for radiation safety of the personnel and environmental protection.

It was demonstrated that average external radiation doses for the workers involved in decommissioning activities did not exceed 0.7 mSv (variation from 0.16 to 1.7 mSv), while internal radiation doses varied from 0.35 to 3.3 µSv.

Density of beta-contamination of the site did not exceed 38 beta-particles/(cm2∙min) which corresponds to background values. The ambient dose equivalent rate of the site was within 0.09-0.15 µSv/h after the work has been done.
Calculation of the Depth Dependence of Relative Biological Effectiveness For Clinical Proton Beams
Authors: Белоусов А. , Belousov A. , Бахтиозин Р. , Bahtiosin R. , Колыва­нова М. , Kolyvanova M. , Крусанов Г. , Krusanov G. , Шулепова Л. , Shulepova L. , Морозов В. , Morozov V.
Published: June 2019

Purpose: Accurate establishing the value of relative biological effectiveness (RBE) for high energy protons is one of the main challenges of modern radiotherapy. The purpose of the study is to calculate the depth dependence of RBE for proton beams forming a spread-out Bragg peak.

Material and methods: Spatial distributions of absorbed dose and dose-average linear energy transfer (LET) for 50-100 MeV (0.5 MeV energy step) monochromatic proton beams were obtained by Monte-Carlo computer simulation using Geant4 software. A linear dependence of RBE on the dose-average LET was used. Absorbed dose distributions were obtained in a water phantom for monochromatic pencil proton beams of 2.5 mm radius. The absorbed dose and the dose-average LET values were calculated in voxels with dimensions of 2×2×0.2 mm.

Results: Calculations of depth dependencies of absorbed dose and dose-average LET for 50–100 MeV monochromatic proton beams were performed. Depth dependencies of RBE for these beams were established. The weighing coefficients values allowing to generate uniformspread-out Bragg peak (SOBP) were determined. Depth distribution of “RBE-weighted” dose and RBE values for SOBP were found.

Conclusion: The impact of the initial beam energy step on the degree of homogeneity of the modified Bragg curve was investigated. It was shown that a step up to 1.5 MeV is acceptable for generate a smooth Bragg curve. The depth dependence of the average RBE value is a complex function, which rapidly changes especially at the far end of the SOBP. RBE may vary up to 10-30 % compared to current clinical value. The linear model of RBE-LET dependence shown in the study can be easily used in dosimetric planning systems, that may will significantly improve the quality of proton radiotherapy.
Prospects of Proton Therapy Combined Technologies in the Treatment of Cancer
Authors: Бушманов Андрей , Bushmanov Andrey , Шейно И. , Sheino I. , Липенгольц А. , Lipengolts A. , Соловьев А. , Solovev A. , Корякин С. , Koryakin S.
Published: June 2019

Purpose: Evaluating the possibilities to increase proton radiotherapy therapeutic efficacy by means of combined (binary) technologies: simultaneous application of proton radiation and special drugs.

Material and methods: Published studies assessing antitumor efficacy of proton radiation together with simultaneous tumor radiosensitizing chemical compounds administration in treating cancer are being reviewed and analyzed.

Results: Two approaches to increase therapeutic efficacy of proton radiotherapy using drugs, which have abnormally large value of proton interaction cross section comparing to soft tissues, can be outlined recently. They are: 1) utilization of proton induced nuclear reactions producing high LET secondary radiation to increase absorbed dose in tumor; 2) utilization of protons and proton track’s secondary electrons interaction with high-Z nanoparticles (Z>52), that leads to redistribution of released proton energy in soft tissues and its localization in tumor volume.

Limited number of the studies devoted to application of 11B(p,3a) nuclear reaction in proton therapy and contradictoriness of the obtained result do not allow to judge so far about the future prospects of the boron containing drugs utilization in proton therapy to increase its antitumor efficacy. However, this approach looks very attractive because of the already existing boron drugs successfully being applied in boron neutron capture therapy. Analysis of the metal nanoparticle application in radiotherapy showed that despite of the promising results showing impressive tumor suppression increase represented in many scientific papers only three pharmaceuticals based on nanoparticles reached Phase I/II Clinical Trials. Radiosensitizing mechanism of metal nanoparticles in radiotherapy is still unrevealed, unstudied and not formalized thus interfering nanoparticle based pharmaceuticals to be approved for Clinical Trials. Quantitative relationship between nanoparticles’ properties (i.e. chemical composition, shape, surface coating etc.), irradiation parameters and final biological effect (therapeutic efficacy) is still undetermined.

Conclusion: Fundamental and applied studies should be carried out to determine and describe the processes underlying in the basis of combined methods of proton radiotherapy. That would allow to perform both proper treatment planning, similar to conventional radiotherapy, as well as the prognosis of the therapy final outcomes in curing malignant tumors.
Total knee arthroplasty after distal femoral osteotomy long-term survivorship and clinical outcomes
Authors: Chalmers B. P. , Limberg A. K. , Athey A. G. , Perry K. I. , Pagnano M. W. , Abdel M. P.
Published: June 2019

Aims

There is little literature about total knee arthroplasty (TKA) after distal femoral osteotomy (DFO). Consequently, the purpose of this study was to analyze the outcomes of TKA after DFO, with particular emphasis on: survivorship free from aseptic loosening, revision, or any re-operation; complications; radiological results; and clinical outcome.

Patients and Methods

We retrospectively reviewed 29 patients (17 women, 12 men) from our total joint registry who had undergone 31 cemented TKAs after a DFO between 2000 and 2012. Their mean age at TKA was 51 years (22 to 76) and their mean body mass index 32 kg/m2(20 to 45). The mean time between DFO and TKA was ten years (2 to 20). The mean follow-up from TKA was ten years (2 to 16). The prostheses were posterior-stabilized in 77%, varus-valgus constraint (VVC) in 13%, and cruciate-retaining in 10%. While no patient had metaphyseal fixation (e.g. cones or sleeves), 16% needed a femoral stem.

Results

The ten-year survivorship was 95% with aseptic loosening as the endpoint, 88% with revision for any reason as the endpoint, and 81% with re-operation for any reason as the endpoint. Three TKAs were revised for instability (n = 2) and aseptic tibial loosening (n = 1). No femoral component was revised for aseptic loosening. Patients under the age of 50 years were at greater risk of revision for any reason (hazard ratio 7; p = 0.03). There were two additional re-operations (6%) and four complications (13%), including three manipulations under anaesthetic (MUA; 10%). The Knee Society scores improved from a mean of 50 preoperatively (32 to 68) to a mean of 93 postoperatively (76 to 100; p < 0.001).

Conclusion

A cemented posterior-stabilized TKA has an 88% ten-year survivorship with revision for any reason as the endpoint. No femoral component was revised for aseptic loosening. Patients under the age of 50 years have a greater risk of revision. The clinical outcome was significantly improved but balancing the knee was challenging in 13% of TKAs requiring VVC. Overall, 10% of TKAs needed an MUA, and 6% of TKAs were revised for instability. Cite this article: Bone Joint J 2019;101-B:660–666.
The HINTEGRA total ankle arthroplasty
Authors: Yang H-Y , Wang S-H , Lee K-B
Published: June 2019

Aims

The purpose of this study was to determine the functional outcome and implant survivorship of mobile-bearing total ankle arthroplasty (TAA) performed by a single surgeon.

Patients and Methods

We reviewed 205 consecutive patients (210 ankles) who had undergone mobile-bearing TAA (205 patients) for osteoarthritis of the ankle between January 2005 and December 2015. Their mean follow-up was 6.4 years (2.0 to 13.4). Functional outcome was assessed using the Ankle Osteoarthritis Scale, American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, 36-Item Short-Form Health Survey (SF-36) score, visual analogue scale, and range of movement. Implant survivorship and complications were also evaluated.

Results

There were significant improvements in all functional outcome categories between the preoperative and final follow-up assessments (p < 0.001). Patients showed marked improvement in clinical outcomes in terms of pain, function, and quality of life. The overall implant survivorship was 91.7% at a mean follow-up of 6.4 years. In all, 33 major complications were identified with a 15.7% rate, resulting in 12 prosthesis failures (5.7%). Periprosthetic osteolysis (19 cases; 9.0%) was the most frequent complication.

Conclusion

Mobile-bearing TAA resulted in improved functional outcomes, a low major complication rate, and excellent implant survivorship at a mean follow-up of 6.4 years. Cite this article: Bone Joint J 2019;101-B:695–701.
Women on the move: administrative data as a safe way to research hidden domestic violence journeys
Authors: Bowstead Janet Christine
Published: June 2019

Domestic violence against women is a significant social issue within the United Kingdom, across Europe and globally. However, it is often difficult to research given the hidden nature of the violence, and the need for many women to continue to keep their experiences secret. This article presents research on women’s relocation journeys, using administrative data from a funding programme which required England-wide monitoring from 2003 to 2011 on housing-related support services. This provided a sample of approximately 18,000 relocation cases per year – a total of over 140,000 journeys to access services – until the data became unavailable due to the end of the funding programme. The article presents some of the substantive findings on domestic violence journeys: the numerical scale and gendered nature of the journeys, the pattern of spatial churn across the country, the geographical scale and administrative boundary issues, and the evidence that women are often on the move both before and after accessing services. The article concludes that administrative data from services could and should be de-identified and used as a safe way to research women on the move due to domestic violence, and enable services and authorities to make better decisions on meeting their needs.
Periods in emotions history: a next step?
Authors: Stearns Peter N.
Published: June 2019

Emotions history has become a significant subfield in the discipline and also offers abundant opportunities for interdisciplinary discussion about change and continuity in emotional standards and experience. To facilitate wider discussion, this article urges more attention to key periods of emotional change. The impact of the Enlightenment and pre-Romanticism eras certainly highlights the later 18th and early 19th centuries, but a significant cluster of changes also emerge in the early 20th century and, some would argue, again today, particularly with regard to the impact of social media. Periodisation discussions encourage a more systematic approach to emotions history and may facilitate dialogue with other emotions disciplines.
Conspicuous consumption and hospitality at a wine festival in China
Authors: O’Regan Michael , Choe Jaeyeon , Yap Matthew
Published: June 2019

The nature of Chinese consumption and hospitality has evolved rapidly since the post-1980s middle class adopted new lifestyles and consumption choices after the opening up of the economy and society. This study explores the logics underpinning conspicuous consumption of wine in China by way of an exploratory factor analysis of 253 respondents at a wine festival. The study found that conspicuous tendencies manifest themselves with wine consumption, but are affected by culture and traditional values. The study found that social and personal influences mediate how individuals perceive and experience consumption in ways that do not wholly follow western practices. This article contributes to the existing hospitality literature by conceptualizing from a consumer perspective, how a product or brand has the potential to become conspicuous within the Chinese hospitality context and explores implications for hospitality research by generating a thorough understanding of links between conspicuous consumption and hospitality.
Towards a personology of a hospitality professional
Authors: Gebbels Maria , Pantelidis Ioannis S. , Goss-Turner Steven
Published: June 2019

This article provides new insights on what makes hospitality professionals by proposing a new framework: the personology of a hospitality professional. This framework is based on an in-depth analysis of the literature on self-efficacy, career inheritance and career commitment. Understanding the key characteristics of people who choose hospitality as their profession is of great importance to an industry that provides one in ten jobs worldwide, and in the United Kingdom alone employs 4.49 million people. The need for quality employees who consider hospitality a long-term career is of paramount importance. Stakeholders often perceive the hospitality industry as a hardworking and low-paying one. If employers wish to retain existing talent and also attract new talent, they need to have a better understanding of their employees’ key characteristics. The proposed personology will enable hospitality stakeholders to identify key indicators that aid in a deeper understanding of what constitutes a hospitality professional. This can facilitate the interview process and yield better recruitment and selection outcomes whilst contributing to the scarcity of knowledge on what being a hospitality professional entails.
Calling for user-centric VR design research in hospitality and tourism
Authors: Han Dai-In Danny , tom Dieck M. Claudia
Published: June 2019

Virtual reality (VR) has enjoyed a steep growth in awareness in society in recent years and is considered a promising tool for the design and enhancement of experiences. However, as research and use cases in the hospitality context are expanding rapidly, it is crucial to define a clearer research direction that aligns the number of scattered studies across various fields. It is time to overcome the boundaries of the technological dimension and explore methods for purposeful VR design. This research note calls for more user-centric VR studies and developments to define the future direction of VR implementations in the hospitality and tourism industry. To achieve this, the authors recommend the use of design methodology with a focus on the first steps in the design process to clearly identify and understand customers’ needs and desires independent of VR technology.
Book Reviews
Authors: Visser Renske , O’Connor Kaori , Korstanje Maximiliano E.
Published: June 2019

Dying to Eat: Cross-Cultural Perspectives on Food, Death, and the Afterlife, Candi K. Cann (ed.) (2017) Lexington: University Press of Kentucky, 208 pp., ISBN 978-0-81317-471-6, h/bk, $65.00

Royal Events: Rituals. Innovations, Meanings Jennifer Laing and Warwick Frost (2018) Abingdon: Routledge, xi + 250 pp., ISBN 978-1-13811-981-9, h/bk, £105

An Anthropological Study of Hospitality: The Innkeeper and the Guest, Amitai Touval (2017) New York, Palgrave Macmillan, 88 pp., ISBN 978-3-31942-049-3, h/bk, £49.00
Digital access, genre bending: Four Seasons in Havana (Viscarret, 2016) and the Ibero-American audio-visual space
Authors: Alvaray Luisela
Published: June 2019

The rapid flow of digital technologies propels us to consider how they may be modifying film and television production and distribution practices, how media formats are transforming and what kinds of contexts of viewership this may be creating. Using the example of Netflix in Latin America, I reflect upon the ways the company, through its online distribution practices, as much as through its newer role as producer, targets niche markets, while universalizing local products. Fundamentally, it is changing local and regional media environments and the ways we relate to them. Focusing on the miniseries Four Seasons in Havana (Viscarret, 2016), I address how streaming services and their move into original programming promote transnational alliances, which is reflected in the narratives and the loosening of media categories as we know them. Format distinctions between film and other forms of audio-visual media are blurring, and new formats may be qualifying cultural patterns differently, ultimately, contributing to the permanent re-creation of transnational imaginaries.
The perfect spectatorship: Culture and criticism in Mexico’s La dictadura perfecta/The Perfect Dictatorship (2014) and Ingobernable/Ungovernable (2017)
Authors: Zavala Pablo
Published: June 2019

La dictadura perfecta/The Perfect Dictatorship (Estrada, 2014) calls attention to the current state of funding, social criticism and censorship in Mexican cinema, and to the state of the cultural and electoral Mexican Left. To explore present and future distribution and production tendencies, I look at how Netflix might provide an alternative venue for Mexican filmmakers and how its Ingobernable/Ungovernable (2017) caters to a global audience, while simultaneously incorporating a timid social criticism that activates identity sensibilities in a Mexican audience. I argue that Estrada’s film(s) – along with the social and cultural impact of leftist movements on a collective Mexican memory – jointly paved the aesthetic and ideological road to making this incorporation palatable.
Analysis of the sensitivity of viscoelastic parameters at the strain-rate of a thermoplastic
Authors: Saadallah Younès , Derfouf Semcheddine , Guerira Belhi
Published: June 2019

The behavior of thermoplastics depends on several factors, mainly time and temperature. The present work is the a study of the dependence of these materials on time. The material considered in this study is a polyamide 6. The applied behavior model is represented by the Kelvin-Voigt viscoelastic mechanism. the mathematical formulation of the equations of the model is put in place and tensile tests at different strain rates are conducted. The parameters model are then identified. These being sensitive to the strain-rate, the relation which links them with it is established by means of an exponential regression. The results test-model are presented and dicussed.
O papel dos Conselhos de Educação no Brasil / The role of the Education Councils in Brazil
Authors: Costa Esmeralda Maria De Oliveira , Fanego Graciela
Published: June 2019

O objetivo do presente estudo foi discutir o papel dos conselhos escolares à luz do controle social. A formação dos Conselhos Municipais de Educação, devem implicar em uma maior autonomia, nas decisões referentes a educação municipal. Contudo, muitos desses Conselhos, criados no afã de cumprir a legislação, não parecem terem atentado para a importância de articular os profissionais da educação, alunos, pais e a comunidade, juntamente com o poder executivo, de forma a elaborarem um planejamento estratégico que possa garantir seu efetivo funcionamento (dos Conselhos).  Os resultados demonstraram que o processo de conquista da autonomia pelos Conselhos acontece em meio a controvérsias, os Conselhos estão ainda a passos lentos para exercer a gestão democrática nas políticas públicas de educação, porém simbolizam um lugar favorável para a participação da sociedade e o controle social mais legítimo, sendo sem dúvida a direção certa para que se alcance uma educação de qualidade.
Theoretical proposal of steps for the implementation of the Industry 4.0 concept
Authors: Cordeiro Gabrielly Araújo , Ordóñez Robert Eduardo Cooper , Ferro Rodrigo
Published: June 2019

Goal: The purpose of this paper is to present a proposal of steps for the implementation of Industry 4.0 in the industrial context, considering management and operational aspects. The reason is to discuss that technological change is accompanied by many organizational implications, in which it is perceivable that some companies already experience strategic and operational turbulence due to the lack of understanding of the this structure’s complexity.

Design / Methodology / Approach: This study assumes an exploratory character because the subject of analysis is still in the knowledge-structuring phase. In this sense, data was collected from the literature review.

Results: A theoretical proposal for the Industry 4.0 implementation framework is presented in flow format. It is organized in steps that cover the strategic and operational aspects during the implementation flow.

Limitations of the investigation: The limitations of this study are directly related to its theoretical nature and the difficulty of finding tools that help in the execution of each proposed stage.

Practical implications: However, based on theoretical insights, a trajectory of a transformation model is proposed, thus this research intends to show clearly and direct how companies can introduce the aspects of Industry 4.0 to their own benefit.

Originality / Value: In this study, a conceptual model is structured, and it indicates a potential of application because it contributes to support and encourage the adoption of technologies and concepts indicated in the Industry 4.0 literature in a structured way.
Blockchain in manufacturing revolution based on machine to machine transaction: a systematic review
Authors: Martins Geraldo Dolce , Gonçalves Rodrigo Franco , Petroni Benedito Cristiano
Published: June 2019

In the last few years, two technological events emerged. First, the rising of Industry 4.0 concepts and technologies such as IoT allowed the direct link between machines on the shop floor, establishing a machine-to-machine communication (M2M). Second, blockchain enables transactions such payments and contracts without a formal reliable or accreditation institutions, such as banks or government.
Goal: The goal of this paper is to explore the state-of-art of the blockchain technology applied to the manufacture sector. In this sense, the option of the M2M transaction being intermediated by blockchain on the shop floor is a hypothesis to be tested. Moreover, it could be questioned if these subjects are being appreciated by the academia.
Design / Methodology / Approach: a systematic review of the literature was conducted, considering blockchain, the industrial context, and the Industry 4.0 related technologies.
Results: As a result, only 12 papers that were classified according to their application fields and practice stages were obtained.
Limitations of the investigation: this field of application is brand new; thus, the available literature is scarce; only 12 papers were obtained.
Practical implications: As the main result, it was identified that the possibilities of blockchain applications to Industry have been poorly explored by literature.
Originality / Value: The paper addresses the possibility of application of blockchain in M2M-based manufacture, and detaches the research gap in the academic literature related to it.