bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Study on Numerical Flow Simulations of a Centrifugal Electronic Cooling Fan Using Four Different Turbulence Models
Authors: Kirchhofer Martin , Krieger Michael , Hofer Dominik
Published: December 2023

In this study the flow field of a centrifugal electronic cooling fan operating at an off-design point of 0 Pa static fan pressure is investigated by means of Computational Fluid Dynamics. The results obtained by four different turbulence models, the realizable k-ϵ model, the SST k-ω model, a Reynolds Stress Model, and Scale-Adaptive Simulation are analyzed and compared. The focus lies on describing how the flow through impeller and volute influences the fan outlet flow field, and velocity profiles and velocity fluctuations at the outlet are compared to previously published measurements. All models tend to underpredict the measured outlet flow rate, but are capable of producing the characteristic C-shaped profile of high velocities, previously determined in Constant Temperature Anemometry measurements. However, the realizable k-ϵ model is significantly too diffusive, leading to blurred velocity contours. The other models exhibit reasonable agreement with the measured flow field, but show differences in a number of aspects. The SST k-ω model, for instance, even produces local inflow in a confined area. The SAS approach overpredicts the length of the lower lobe of the C-shape. The research is relevant to improve simulation results of impingement cooling and heat sink optimization using centrifugal fans.
A Deep Learning Approach to Improve the Control of Dynamic Wireless Power Transfer Systems
Authors: Bertoluzzo Manuele , Di Barba Paolo , Forzan Michele , Mognaschi Maria Evelina , Sieni Elisabetta
Published: December 2023

In this paper, an innovative approach for the fast estimation of the mutual inductance between transmitting and receiving coils for Dynamic Wireless Power Transfer Systems (DWPTSs) is implemented. To this end, a Convolutional Neural Network (CNN) is used; an image representing the geometry of two coils that are partially misaligned is the input of the CNN, while the output is the corresponding inductance value. Finite Element Analyses are used for the computation of the inductance values needed for CNN training. This way, thanks to a fast and accurate inductance estimated by the CNN, it is possible to properly manage the power converter devoted to charge the battery, avoiding the wind up of its controller when it attempts to transfer power in poor coupling conditions.
Hydraulic Radial Drilling Using a Rotary Hydraulic Nozzle Aimed at Increasing the Exploitation of Deposits
Authors: Toczek Przemyslaw , Wisniowski Rafal , Zlotkowski Albert , Teper Wojciech
Published: December 2023

The exploration and development of new hydrocarbon deposits face increasing challenges, primarily driven by the shift away from hydrocarbons towards renewable energy sources like shallow geothermal deposits, wind farms, and photovoltaics. This shift necessitates finding solutions that minimize environmental impact and enable increased energy extraction from existing or decommissioned fields and wells. This paper explores the possibility of excavating from potentially depleted fields, where a significant portion (up to 85%) of the reservoir’s resources remain unrecoverable due to low reservoir energy. To address this, secondary and tertiary exploitation methods are proposed involving the supply of external energy to increase the pressure in the reservoir layer, thereby enhancing resource exploitation. One of the suggested tertiary methods involves reaming the deposit with multiple small-diameter radial holes using a hydraulic drilling nozzle. The entire process comprises several key components, including the coiled tubing unit (CTU), high-pressure flexible hose, window drilling kit for casing pipe, kit for positioning the exit of the hydraulic drilling head from the casing pipe, anchor, and hydraulic drilling head attached to the end of the high-pressure flexible hose. This method aims to increase the contact between the reservoir layer and the wellbore, potentially leading to an increase in or initiation of exploitation in certain deposit scenarios. The described method presents an environmentally friendly approach, eliminating the need for drilling new boreholes and offering cost-effective access to resources in decommissioned deposits with insufficient reservoir energy for self-exploitation. The applicability of this method to extract methane from coalbed seams is also mentioned in this article. In a separate article, the authors detail the design of a hydraulic drilling nozzle specifically for reaming the reservoir layer.
Time Reversal vs. Integration of Time Reversal with Convolution Neural Network in Diagnosing Partial Discharge in Power Transformer
Authors: Sekatane Permit Mathuhu , Bokoro Pitshou
Published: December 2023

Partial discharge (PD) is a common issue in power transformers that can lead to catastrophic failures if left undetected. Time reversal (TR) is a well-known technique in signal processing that can reconstruct signals by reversing the direction of time. The paper investigates the use of time reversal and the integration of time reversal with convolution neural networks (CNNs) for diagnosing PD in power transformers. We compare the performance of these techniques on a dataset of PD signals collected from power transformers. We propose a novel method of using time reversal as a pre-processing step to improve the accuracy of CNNs on noisy or distorted signals. Our experimental results demonstrate that this approach can significantly enhance the performance of CNNs on various datasets, including speech, audio, and image datasets. This paper provides a novel approach to signal processing and demonstrates the potential of time reversal as a pre-processing step in CNNs.
Determinants of the Efficiency of Electricity Generation in Latin America and Caribbean Countries Using a Cragg’s Regression Model
Authors: Cuadros Sebastian , Rodríguez Yeny E. , Contreras Javier
Published: December 2023

Measuring and understanding the evolution of the electricity generation efficiency sector is a relevant task for policymakers. This study focuses on assessing the determinants of electricity generation efficiency across 24 countries in Latin America and the Caribbean between 2000 and 2020. A hurdle model was employed to account for the censored nature of the dependent variable. The findings show a positive impact of opening up the electricity sector in fully efficient countries. Market liberalization and the involvement of privately owned power plants contribute to efficiency gains in inefficient countries. Additionally, the tariff protectionism level exhibits positive effects for completely efficient and inefficient countries. These results provide valuable insights, as less-efficient countries can glean strategies from their more efficient counterparts to enhance their electricity generation efficiency.
New Reference Current Calculation Method of a Hybrid Power Filter Based on Customer Harmonic Emission
Authors: Herman Leopold , Špelko Aljaž
Published: December 2023

This paper presents a novel reference current calculation method for harmonics mitigation and reactive power compensation in power systems. This method was applied to a unique hybrid power filter topology. The motivation for this study comes from the increasing power quality issues, such as harmonic distortion and resonances, caused by the widespread integration of converter-interfaced generation (CIG) and modern nonlinear loads into the power system in recent years. The goal of this study is to propose a cost-effective and practical solution for current harmonics filtering and power factor correction by combining the advantages of passive and active filters into a hybrid solution. The developed reference current calculation method, which is based on customer current harmonic emissions, enables effective reference current calculation. Theoretical analyses along with simulation results obtained from a medium-voltage benchmark model in PSCAD verify the effectiveness of the proposed solution in harmonics filtering and show a substantial reduction in filter current ratings across various harmonic components. In addition, the simulation results were evaluated by comparison with the results obtained from a real-time simulator.
Short-Term Load Forecasting Using an LSTM Neural Network for a Grid Operator
Authors: Caicedo-Vivas Joan Sebastian , Alfonso-Morales Wilfredo
Published: December 2023

Electricity is crucial for daily life due to the number of activities that depend on it. To forecast future electric load, which changes over time and depends on various factors, grid operators (GOs) must create forecasting models for various time horizons with a high degree of accuracy because the results have a huge impact on their decision-making regarding, for example, the scheduling of power units to supply user consumption in the short or long term or the installation of new power plants. This has led to the exploration of multiple techniques like statistical models and Artificial Intelligence (AI), with Machine-Learning and Deep-Learning algorithms being the most popular in this latter field. This paper proposes a neural network-based model to forecast short-term load for a Colombian grid operator, considering a seven-day time horizon and using an LSTM recurrent neural network with historical load values from a region in Colombia and calendar features such as holidays and the current month corresponding to the target week. Unlike other LSTM implementations found in the literature, in this work, the LSTM cells read multiple load measurements at once, and the additional information (holidays and current month) is concatenated to the output of the LSTM. The result is used to feed a fully connected neural network to obtain the desired forecast. Due to social problems in the country, the load data presents a strange behavior, which, in principle, affects the prediction capacity of the model. Still, it is eventually able to adjust its forecasts accordingly. The regression metric MAPE measures the model performance, with the best predicted week having an error of 1.65% and the worst week having an error of 26.22%. Additionally, prediction intervals are estimated using bootstrapping.
Total and Free Hydrogen Cyanide Content and Profile of Bioactive Amines in Commercial Tucupi, a Traditionally Derived Cassava Product Widely Consumed in Northern Brazil
Authors: Brito Brenda de Nazaré do Carmo , Martins Mayara Galvão , Chisté Renan Campos , Lopes Alessandra Santos , Gloria Maria Beatriz Abreu , Pena Rosinelson da Silva
Published: December 2023

Tucupi is a broth derived from cassava roots which is produced after the spontaneous fermentation of manipueira (the liquid portion obtained by pressing cassava roots), followed by cooking. This product is widely consumed along with traditional dishes in the Brazilian Amazonia and is already used in different places worldwide. In this study, tucupi obtained from the markets of Belém (Pará, Brazil) and produced using agroindustrial (11 samples) and non-agroindustrial (11 samples) units were investigated to determine their physicochemical characteristics, total and free HCN contents, and free bioactive amine profiles. Most of the samples showed significant variations (p ≤ 0.05) in pH (2.82–4.67), total acidity (0.14–1.36 g lactic acid/100 mL), reducing sugars (up to 2.33 g/100 mL), and total sugars (up to 4.35 g/100 mL). Regarding the amines, four biogenic amines (0.5–4.2 mg/L tyramine, 1.0–23.1 mg/L putrescine, 0.5–66.8 mg/L histamine, and 0.6–2.9 mg/L tryptamine) and one polyamine (0.4–1.7 mg/L spermidine) were identified in the tucupi samples. Even in the tucupi produced using the agroindustrial units, which had quality seals provided by the local regulatory agency, high levels of biogenic amines (4.4–78.2 mg/L) were observed, as well as high dosages of total (8.87–114.66 mg/L) and free (0.80–38.38 mg/L) HCN. These facts highlight the need for better knowledge regarding the product manufacturing process to establish standardization and high-quality conditions for tucupi processing since high contents of biogenic amines and HCN are commonly associated with adverse health effects.
Microencapsulation of Juniper and Black Pepper Essential Oil Using the Coacervation Method and Its Properties after Freeze-Drying
Authors: Napiórkowska Alicja , Szpicer Arkadiusz , Wojtasik-Kalinowska Iwona , Perez Maria Dolores Torres , González Herminia Dominguez , Kurek Marcin Andrzej
Published: December 2023

Essential oils are mixtures of chemical compounds that are very susceptible to the effects of the external environment. Hence, more attention has been drawn to their preservation methods. The aim of the study was to test the possibility of using the classical model of complex coacervation for the microencapsulation of essential oils. Black pepper (Piper nigrum) and juniper (Juniperus communis) essential oils were dissolved in grape seed (GSO) and soybean (SBO) oil to minimize their loss during the process, and formed the core material. Various mixing ratios of polymers (gelatin (G), gum Arabic (GA)) were tested: 1:1; 1:2, and 2:1. The oil content was 10%, and the essential oil content was 1%. The prepared coacervates were lyophilized and then screened to obtain a powder. The following analyses were determined: encapsulation efficiency (EE), Carr index (CI), Hausner ratio (HR), solubility, hygroscopicity, moisture content, and particle size. The highest encapsulation efficiency achieved was within the range of 64.09–59.89%. The mixing ratio G/GA = 2:1 allowed us to obtain powders that were characterized by the lowest solubility (6.55–11.20%). The smallest particle sizes, which did not exceed 6 μm, characterized the powders obtained by mixing G/GA = 1:1. All powder samples were characterized by high cohesiveness and thus poor or very poor flow (CI = 30.58–50.27, HR = 1.45–2.01).
Evaluations of NSAIDs and Opioids as Analgesics in Pediatric Oncology
Authors: Leal Eduardo Ladeia , Santos Paulo Caleb Júnior Lima , Gonçalves Thuane Sales , Nascimento Mariana Martins Gonzaga do , Cruz Fábio Cardoso , Nascimento Flávia Borelli Gomes do , Kasa Carolina Paula Jesus
Published: December 2023

As one of the leading causes of death in childhood, cancer also causes discomfort to pediatric patients. Even with guidelines for pain management, more than half of hospitalized children have intense and unrelieved pain. The present work aims to describe the intensity of pain and its pharmacological management in a pediatric oncology population. Patients aged 0 to 17 years old, diagnosed with cancer, who were admitted to a children’s oncology hospital and had well-documented data on pain management in their medical records were included. A total of 333 patients were included, mostly male (55.8%) with a mean age of 7.9 years. A substantial portion of the patient cohort (51.4%) initially reported experiencing pain of moderate intensity during the first assessment. Subsequently, following the pharmacological intervention, a significant proportion of patients (90.1%) reported complete alleviation of pain. The predominant pharmaceutical agents utilized for pain management encompassed metamizole (76.6%) and morphine (10.2%). All pharmacological interventions used were able to significantly reduce patients’ pain. This study underscores the utilization of different pharmacological classes to achieve notable reductions in pain intensity among patients grappling with severe pain.
Moving on from a Diesel Mindset—Understanding Enablers and Challenges for Electrifying Road Freight Using Stakeholder Engagement
Authors: Jha Sourabh , Davies Huw , Pandey Mukesh , Deniz Özcan , Jones Perry
Published: December 2023

Achieving net zero by 2050 requires the decarbonisation of road transport. Electrification is recognised as a market-ready solution for certain transport segments, but it still poses a considerable challenge when applied to road freight. Any consensus on the technology choice for road freight electrification has still not been established. Embedding stakeholder input in the approach to address the technology adoption challenge has proven useful in uncovering various perspectives, which can provide useful insights into managing such transitions. This review paper hence took a three-step approach where the findings from the initial step of the literature search were taken up for the second step of stakeholder validation and feedback. The third step involved an analysis of the input gathered and the subsequent literature review to arrive at the conclusions. The outcome from the stakeholder engagement suggests that any specific technology can only support the transition to electrified road freight if enabled by system changes around policy, infrastructure, user behaviour, and the societal setup A follow-up literature review validated the need for a sociotechnical approach to such transitions where system changes are involved. The review also found gaps in the literature when it comes to embedding such sociotechnical approaches to technology adoption for road freight transport.
Agarose Gel Characterization for the Fabrication of Brain Tissue Phantoms for Infrared Multispectral Vision Systems
Authors: Albor-Ramírez Efraín , Reyes-Alberto Miguel , Vidal-Flores Luis M. , Gutierrez-Herrera Enoch , Padilla-Castañeda Miguel A.
Published: December 2023

Synthetic phantoms that recreate the characteristics of biological tissues are valuable tools for systematically studying and comprehending physiologies, pathologies, and biological processes related to tissues. The reproduction of mechanical and optical properties allows for the development and evaluation of novel systems and applications in areas such as imaging, optics, ultrasound, or dosimetry, among others. This paper proposes a methodology for manufacturing agarose-based phantoms that mimics the optical properties of healthy brain tissue within the wavelength infrared range of 800 to 820 nm. The fabrication of such phantoms enables the possibility of testing and experimentation in controlled and safe environments toward the design of new near-infrared multispectral imaging systems in neurosurgery. The results of an experimental optical characterization study indicate the validity and reliability of the proposed method for fabricating brain tissue phantoms in a cost-effective and straightforward fashion.
Neglected Dislocation in Adults: A New Therapeutic Strategy for an Uncommon Condition
Authors: García de la Blanca Juan Carlos , Cuarental García Javier , Luengo Gonzalo , Martí Rafael , Ramos Luis Rafael
Published: December 2023

(1) Background: Neglected hip dislocation is an uncommon condition, especially in developed countries because dislocations are considered trauma emergencies and thus are treated early. They are usually treated with methods used in commonly occurring dislocations. The aim of this study is to detail a two-stage strategy for neglected hip dislocations in adults applied in a complicated case. (2) Case presentation: We present a complicated case of neglected hip dislocation in a patient with an associated neurological condition. Two-stage open reduction was performed combined with arthrodiastasis and Ilizarov external fixators. After complications requiring a third intervention, the joint was stabilized, and the patient has presented no more episodes to date. (3) Conclusions: Arthrodiastasis has been used to treat these conditions. Comparing it with the other methods described in the literature, it seems to be a good therapeutic strategy, especially in elderly patients. Because of the limited number of studies, we cannot establish the most efficient therapeutic method, but we believe that the described strategy can be useful for patients with this condition.
Effects of Different Protocols of Moderate-Intensity Intermittent Hypoxic Training on Mental Health and Quality of Life in Brazilian Adults Recovered from COVID-19: The AEROBICOVID Double-Blind Randomized Controlled Study
Authors: Merellano-Navarro Eugenio , Camacho-Cardenosa Marta , Costa Gabriel Peinado , Wiggers Ester , Marcolino Putti Germano , Evandro Nogueira Jonatas , Aparecida da Silva Lizzi Elisangela , Trapé Átila Alexandre
Published: December 2023

The aim of this study was to investigate the effects of different protocols of moderate-intensity intermittent hypoxic training in patients who had recovered from COVID-19 on quality of life (QoL) and mental health. The sample of this clinical trial-controlled double-blind study consisted of 67 participants aged 30–69 years, who were organized randomly according to Normoxia, Hypoxia, Hypoxia Recovery or Control Group. Eight weeks of cycle ergometer training were performed with a frequency of three training sessions per week in normoxic or hypoxic conditions (with or without hypoxic recovery). Health-related QoL and Mental Health Status were evaluated by 12-Item Short Form Survey and Depression Anxiety and Stress Scale instruments, respectively. All training groups improved the QoL’s physical dimensions (Baseline–Post: Normoxia Group 42.1 (11.0)–48.7 (7.0), Hypoxia Group 46.9 (11.8)–53.5 (6.6) and Hypoxia Recovery Group 45.8 (9.2)–51.1 (5.3)) and mental dimensions (Baseline–Post: Normoxia Group 48.8 (7.9)–54.6 (4.6), Hypoxia Group 45.2 (7.7)–53.2 (3.8) and Hypoxia Recovery Group 46.5 (9.7)–52.0 (9.9)). Regarding mental health outcomes, all training groups decreased depressive symptoms (66.7% Normoxia, 31.2% Hypoxia Recovery and 31% Hypoxia groups), anxiety symptoms (46.5% Normoxia, 45.9% Hypoxia Recovery and 39.5% in the Hypoxia groups) and stress symptoms (40.6% Normoxia, 36.3% Hypoxia Recovery and 22.1% Hypoxia groups). Significant statistical difference was not found between groups. Normoxic and hypoxic training showed a similar effect on QoL and the mental health of Brazilian adults who had recovered from COVID-19.
Zinc Oxide Nanoparticles in Leather Conservation: Exploring the Potential of Hydroxypropyl Cellulose/Zinc Oxide Nanocomposite as a Leather Consolidation Agent
Authors: Koochakzaei Alireza , Ghane Zahra , Mohammadi Achachluei Mohsen
Published: December 2023

This research presents a comprehensive study on the application of hydroxypropyl cellulose/zinc oxide nanocomposite (HPC/ZnO NC) as an effective consolidant in leather conservation. The critical focus is to prevent photooxidative degradation, a significant challenge in preserving historical leather artifacts. The nanocomposite was evaluated for its protective capabilities against environmental stressors like UV radiation and moisture, mechanical robustness, and potential to stabilize acid-damaged leather. The uniform dispersion of ZnO NPs in the HPC matrix was revealed as crucial for improving leather properties, which was confirmed through SEM imaging. The HPC/ZnO NC coating effectively prevented UV-induced microcracks, surface degradation and collagen denaturation. It also demonstrated enhanced mechanical resistance, inhibiting the reduction in leather’s maximum tolerable force and increasing the elongation index, even after aging. Additionally, it exhibited improved water-repellent properties and increased the pH of the leather, offering potential benefits for the treatment of acid-degraded leathers. Overall, the findings affirm that the application of HPC/ZnO NC significantly augments the physical and mechanical properties of leather, providing enhanced resistance to environmental degradation.
Early-Onset Ovarian Cancer <30 Years: What Do We Know about Its Genetic Predisposition?
Authors: Horackova Klara , Janatova Marketa , Kleiblova Petra , Kleibl Zdenek , Soukupova Jana
Published: December 2023

Ovarian cancer (OC) is one of the leading causes of cancer-related deaths in women. Most patients are diagnosed with advanced epithelial OC in their late 60s, and early-onset adult OC diagnosed ≤30 years is rare, accounting for less than 5% of all OC cases. The most significant risk factor for OC development are germline pathogenic/likely pathogenic variants (GPVs) in OC predisposition genes (including BRCA1, BRCA2, BRIP1, RAD51C, RAD51D, Lynch syndrome genes, or BRIP1), which contribute to the development of over 20% of all OC cases. GPVs in BRCA1/BRCA2 are the most prevalent. The presence of a GPV directs tailored cancer risk-reducing strategies for OC patients and their relatives. Identification of OC patients with GPVs can also have therapeutic consequences. Despite the general assumption that early cancer onset indicates higher involvement of hereditary cancer predisposition, the presence of GPVs in early-onset OC is rare (<10% of patients), and their heritability is uncertain. This review summarizes the current knowledge on the genetic predisposition to early-onset OC, with a special focus on epithelial OC, and suggests other alternative genetic factors (digenic, oligogenic, polygenic heritability, genetic mosaicism, imprinting, etc.) that may influence the development of early-onset OC in adult women lacking GPVs in known OC predisposition genes.
Viral Diversity in Samples of Freshwater Gastropods Benedictia baicalensis (Caenogastropoda: Benedictiidae) Revealed by Total RNA-Sequencing
Authors: Butina Tatyana V. , Zemskaya Tamara I. , Bondaryuk Artem N. , Petrushin Ivan S. , Khanaev Igor V. , Nebesnykh Ivan A. , Bukin Yurij S.
Published: December 2023

Previously, the main studies were focused on viruses that cause disease in commercial and farmed shellfish and cause damage to food enterprises (for example, Ostreavirusostreidmalaco1, Aurivirus haliotidmalaco1 and Aquabirnavirus tellinae). Advances in high-throughput sequencing technologies have extended the studies to natural populations of mollusks (and other invertebrates) as unexplored niches of viral diversity and possible sources of emerging diseases. These studies have revealed a huge diversity of mostly previously unknown viruses and filled gaps in the evolutionary history of viruses. In the present study, we estimated the viral diversity in samples of the Baikal endemic gastropod Benedictia baicalensis using metatranscriptomic analysis (total RNA-sequencing); we were able to identify a wide variety of RNA-containing viruses in four samples (pools) of mollusks collected at three stations of Lake Baikal. Most of the identified viral genomes (scaffolds) had only distant similarities to known viruses or (in most cases) to metagenome-assembled viral genomes from various natural samples (mollusks, crustaceans, insects and others) mainly from freshwater ecosystems. We were able to identify viruses similar to those previously identified in mollusks (in particular to the picornaviruses Biomphalaria virus 1 and Biomphalaria virus 3 from the freshwater gastropods); it is possible that picorna-like viruses (as well as a number of other identified viruses) are pathogenic for Baikal gastropods. Our results also suggested that Baikal mollusks, like other species, may bioaccumulate or serve as a reservoir for numerous viruses that infect a variety of organisms (including vertebrates).
RNA and Single-Stranded DNA Phages: Unveiling the Promise from the Underexplored World of Viruses
Authors: Nguyen Huong Minh , Watanabe Shinya , Sharmin Sultana , Kawaguchi Tomofumi , Tan Xin-Ee , Wannigama Dhammika Leshan , Cui Longzhu
Published: December 2023

RNA and single-stranded DNA (ssDNA) phages make up an understudied subset of bacteriophages that have been rapidly expanding in the last decade thanks to advancements in metaviromics. Since their discovery, applications of genetic engineering to ssDNA and RNA phages have revealed their immense potential for diverse applications in healthcare and biotechnology. In this review, we explore the past and present applications of this underexplored group of phages, particularly their current usage as therapeutic agents against multidrug-resistant bacteria. We also discuss engineering techniques such as recombinant expression, CRISPR/Cas-based genome editing, and synthetic rebooting of phage-like particles for their role in tailoring phages for disease treatment, imaging, biomaterial development, and delivery systems. Recent breakthroughs in RNA phage engineering techniques are especially highlighted. We conclude with a perspective on challenges and future prospects, emphasizing the untapped diversity of ssDNA and RNA phages and their potential to revolutionize biotechnology and medicine.
On the Origin of Cultivated Roses: DNA Authentication of the Bourbon Rose Founding Pedigree
Authors: Alioua Abdelmalek , Heitzler Pascal
Published: December 2023

Rose flowers have been cultivated for their fragrance and their garden value since ancient times. Very ancient cultivars became famous locally for their specific use, and competitive horticultural activities progressively established, leading, with time, to landraces with limited polymorphism. The most famous examples are the oil-bearing Damask roses from Iran and the Yueyue Fen garden strain from China. In 1817, a new rose, allegedly a hybrid from the two previous lineages, was discovered at Reunion. From this plant, as early as the 1820s, a new founder group, the Bourbon roses, was developed in France, which immediately stirred up deep passions among botanists and skilled enthusiasts. Today, more than 30,000 named cultivars have been raised either as garden and landscape plants for the cut rose market or as indoor pot plants. The market handles billions of euros a year, making the rose the most economically important crop worldwide. Following the inheritance of SSR DNA markers, we here propose a reconstitution of the very early lineage of Bourbon roses, clarifying one of the major steps, if not the major one, that links these very ancient heritage roses to modern roses.
Exercise Capacity and Clinical Outcomes in Chronic Heart Failure Patients with Mild Tricuspid Regurgitation
Authors: Nakamura Kosuke , Ishizaka Suguru , Omote Kazunori , Yasui Yutaro , Mizuguchi Yoshifumi , Takenaka Sakae , Shimono Yui , Motoi Ko , Aoyagi Hiroyuki , Tamaki Yoji , Kazui Sho , Takahashi Yuki , Saiin Kohei , Naito Seiichiro , Tada Atsushi , Kobayashi Yuta , Sato Takuma , Kamiya Kiwamu , Nagai Toshiyuki , Anzai Toshihisa
Published: December 2023

Aim: The present study aimed to investigate the impact of mild tricuspid regurgitation (TR) on the exercise capacity or clinical outcomes in patients with chronic heart failure (CHF). Methods and Results: The study enrolled 511 patients with CHF who underwent cardiopulmonary exercise testing (CPET) between 2013 and 2018. The primary outcome was a composite of heart failure hospitalization and death. Patients with mild TR (n = 324) or significant TR (moderate or greater; n = 60) displayed worse NHYA class and reduced exercise capacity on CPET than those with non-TR (n = 127), but these were more severely impaired in patients with significant TR. A total of 90 patients experienced events over a median follow-up period of 3.3 (interquartile range 0.8–5.5) years. Patients with significant TR displayed a higher risk of events, while patients with mild TR had a 3.0-fold higher risk of events than patients with non-TR (hazard ratio (HR) 3.01; 95% confidence interval (CI), 1.50–6.07). Multivariate Cox regression analysis showed that, compared with non-TR, mild TR was associated with increased adverse events, even after adjustment for co-variates (HR 2.97; 95% CI, 1.35–6.55). Conclusions: TR severity was associated with worse symptoms, reduced exercise capacity, and poor clinical outcomes. Even patients with mild TR had worse clinical characteristics than those with non-TR.
Molecular Genetic Diversity of Local and Exotic Durum Wheat Genotypes and Their Combining Ability for Agronomic Traits under Water Deficit and Well-Watered Conditions
Authors: Galal Ahmed A. , Safhi Fatmah A. , El-Hity Mahmoud A. , Kamara Mohamed M. , Gamal El-Din Eman M. , Rehan Medhat , Farid Mona , Behiry Said I. , El-Soda Mohamed , Mansour Elsayed
Published: December 2023

Water deficit poses significant environmental stress that adversely affects the growth and productivity of durum wheat. Moreover, projections of climate change suggest an increase in the frequency and severity of droughts, particularly in arid regions. Consequently, there is an urgent need to develop drought-tolerant and high-yielding genotypes to ensure sustained production and global food security in response to population growth. This study aimed to explore the genetic diversity among local and exotic durum wheat genotypes using simple sequence repeat (SSR) markers and, additionally, to explore the combining ability and agronomic performance of assessed durum wheat genotypes and their 28 F1 crosses under normal and drought stress conditions. The investigated SSRs highlighted and confirmed the high genetic variation among the evaluated parental durum wheat genotypes. These diverse eight parental genotypes were consequently used to develop 28 F1s through a diallel mating design. The parental durum genotypes and their developed 28 F1s were assessed under normal and drought stress conditions. The evaluated genotypes were analyzed for their general and specific combining abilities as well as heterosis for agronomic traits under both conditions. The local cultivar Bani-Suef-7 (P8) is maintained as an effective combiner for developing shortened genotypes and improving earliness. Moreover, the local cultivars Bani-Suef-5 (P7) and Bani-Suef-7 (P8) along with the exotic line W1520 (P6) demonstrated excellent general combining ability for improving grain yield and its components under drought stress conditions. Furthermore, valuable specific hybrid combinations, W988 × W994 (P1 × P2), W996 × W1518 (P3 × P5), W1011 × W1520 (P4 × P6), and Bani-Suef-5 × Bani-Suef-7 (P7 × P8), were identified for grain yield and its components under drought stress conditions. The assessed 36 genotypes were grouped according to tolerance indices into five clusters varying from highly drought-sensitive genotypes (group E) to highly drought-tolerant (group A). The genotypes in cluster A (two crosses) followed by thirteen crosses in cluster B displayed higher drought tolerance compared to the other crosses and their parental genotypes. Subsequently, these hybrids could be considered valuable candidates in future durum wheat breeding programs to develop desired segregants under water-deficit conditions. Strong positive relationships were observed between grain yield and number of grains per spike, plant height, and 1000-grain weight under water-deficit conditions. These results highlight the significance of these traits for indirect selection under drought stress conditions, particularly in the early stages of breeding, owing to their convenient measurability.
The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation
Authors: Malkawi Dima , Savsani Kush , Alfonso Anjelica , Lee Seung Duk , James Nicholas , Sarkar Devanand , Imai Daisuke , Khan Aamir , Sharma Amit , Kumaran Vinay , Bruno David , Cotterell Adrian , Levy Marlon F.
Published: December 2023

Despite improvements in short-term and long-term outcomes of liver transplant patients, the discrepancy between the number of available livers and transplant candidates continues to increase. The use of expanded criteria donors is one strategy that can be used to address donor shortages. In recent years, preservation strategies such as normothermic machine perfusion (NMP) have been explored to improve the preservation of organs and test their viability before transplantation. We reviewed the recent literature and trials assessing the use of NMP in the setting of liver transplantation. Multiple feasibility trials have demonstrated the clinical prospect of NMP and proved its numerous advantages compared to conventional static cold storage. These advantages include preservation and viability assessment of high-risk donor allografts and grafts that would have otherwise been discarded. This review aims to address the topic of liver NMP in the setting of current and future applications in the setting of extended criteria donor grafts.
New Third-Order Finite Volume Unequal-Sized WENO Lagrangian Schemes for Solving Euler Equations
Authors: Tan Yan , Lv Hui , Zhu Jun
Published: December 2023

In this paper, new third-order finite volume unequal-sized weighted essentially non-oscillatory (US-WENO) Lagrangian schemes are designed to solve Euler equations in two and three dimensions. The spatial reconstruction procedures are implemented by using a convex combination of a quadratic polynomial with several linear polynomials specified on unequal-sized stencils, so the new US-WENO Lagrangian schemes can achieve the designed third-order accuracy and maintain an essentially non-oscillatory property near strong discontinuities in multi-dimensions. Unlike the traditional WENO reconstruction procedures specified on unstructured meshes, the linear weights of these new two-dimensional and three-dimensional US-WENO spatial reconstructions can be selected as any positive numbers as long as their summation equals one and they are not related to the local mesh topology or the location of quadrature points. Moreover, the linear weights do not have to be recalculated even if the grid moves with the fluid, avoiding the appearance of negative linear weights, thus improving computation efficiency and robustness in multi-dimensional Lagrangian numerical simulations. Finally, extensive benchmark numerical cases are employed to display the excellent capability of the presented US-WENO Lagrangian schemes.
Anticipated BSDEs Driven by Fractional Brownian Motion with a Time-Delayed Generator
Authors: Zhang Pei , Ibrahim Adriana Irawati Nur , Mohamed Nur Anisah
Published: December 2023

This article describes a new form of an anticipated backward stochastic differential equation (BSDE) with a time-delayed generator driven by fractional Brownian motion, further known as fractional BSDE, with a Hurst parameter H∈(1/2,1). This study expands upon the findings of the anticipated BSDE by considering the scenario when the driver is fractional Brownian motion rather instead of standard Brownian motion. Additionally, the generator incorporates not only the present and future but also the past. We will demonstrate the existence and uniqueness of the solutions to these equations by employing the fixed point theorem. Furthermore, an equivalent comparison theorem is derived.
A Multifaceted Computational Approach to Understanding the MERS-CoV Main Protease and Brown Algae Compounds’ Interaction
Authors: Gattan Hattan S. , Mahmoud Alawi Maha , Bajrai Leena H. , Alandijany Thamir A. , Alsaady Isra M. , El-Daly Mai M. , Dwivedi Vivek Dhar , Azhar Esam I.
Published: December 2023

Middle East Respiratory Syndrome (MERS) is a viral respiratory disease caused b a special type of coronavirus called MERS-CoV. In the search for effective substances against the MERS-CoV main protease, we looked into compounds from brown algae, known for their medicinal benefits. From a set of 1212 such compounds, our computer-based screening highlighted four—CMNPD27819, CMNPD1843, CMNPD4184, and CMNPD3156. These showed good potential in how they might attach to the MERS-CoV protease, comparable to a known inhibitor. We confirmed these results with multiple computer tests. Studies on the dynamics and steadiness of these compounds with the MERS-CoV protease were performed using molecular dynamics (MD) simulations. Metrics like RMSD and RMSF showed their stability. We also studied how these compounds and the protease interact in detail. An analysis technique, PCA, showed changes in atomic positions over time. Overall, our computer studies suggest brown algae compounds could be valuable in fighting MERS. However, experimental validation is needed to prove their real-world effectiveness.
Simplified Synthesis of Renieramycin T Derivatives to Target Cancer Stem Cells via β-Catenin Proteasomal Degradation in Human Lung Cancer
Authors: Ei Zin Zin , Racha Satapat , Yokoya Masashi , Hotta Daiki , Zou Hongbin , Chanvorachote Pithi
Published: December 2023

Cancer stem cells (CSCs) found within cancer tissue play a pivotal role in its resistance to therapy and its potential to metastasize, contributing to elevated mortality rates among patients. Significant strides in understanding the molecular foundations of CSCs have led to preclinical investigations and clinical trials focused on CSC regulator β-catenin signaling targeted interventions in malignancies. As part of the ongoing advancements in marine-organism-derived compound development, it was observed that among the six analogs of Renieramycin T (RT), a potential lead alkaloid from the blue sponge Xestospongia sp., the compound DH_32, displayed the most robust anti-cancer activity in lung cancer A549, H23, and H292 cells. In various lung cancer cell lines, DH_32 exhibited the highest efficacy, with IC50 values of 4.06 ± 0.24 μM, 2.07 ± 0.11 μM, and 1.46 ± 0.06 μM in A549, H23, and H292 cells, respectively. In contrast, parental RT compounds had IC50 values of 5.76 ± 0.23 μM, 2.93 ± 0.07 μM, and 1.52 ± 0.05 μM in the same order. Furthermore, at a dosage of 25 nM, DH_32 showed a stronger ability to inhibit colony formation compared to the lead compound, RT. DH_32 was capable of inducing apoptosis in lung cancer cells, as demonstrated by increased PARP cleavage and reduced levels of the proapoptotic protein Bcl2. Our discovery confirms that DH_32 treatment of lung cancer cells led to a reduced level of CD133, which is associated with the suppression of stem-cell-related transcription factors like OCT4. Moreover, DH_32 significantly suppressed the ability of tumor spheroids to form compared to the original RT compound. Additionally, DH_32 inhibited CSCs by promoting the degradation of β-catenin through ubiquitin–proteasomal pathways. In computational molecular docking, a high-affinity interaction was observed between DH_32 (grid score = −35.559 kcal/mol) and β-catenin, indicating a stronger binding interaction compared to the reference compound R9Q (grid score = −29.044 kcal/mol). In summary, DH_32, a newly developed derivative of the right-half analog of RT, effectively inhibited the initiation of lung cancer spheroids and the self-renewal of lung cancer cells through the upstream process of β-catenin ubiquitin–proteasomal degradation.
NanoBubble-Mediated Oxygenation: Elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies
Authors: Viafara Garcia Sergio M. , Khan Muhammad Saad , Haidar Ziyad S. , Acevedo Cox Juan Pablo
Published: December 2023

Worldwide, hypoxia-related conditions, including cancer, COVID-19, and neuro-degenerative diseases, often lead to multi-organ failure and significant mortality. Oxygen, crucial for cellular function, becomes scarce as levels drop below 10 mmHg (<2% O2), triggering mitochondrial dysregulation and activating hypoxia-induced factors (HiFs). Herein, oxygen nanobubbles (OnB), an emerging versatile oxygen delivery platform, offer a novel approach to address hypoxia-related pathologies. This review explores OnB oxygen delivery strategies and systems, including diffusion, ultrasound, photodynamic, and pH-responsive nanobubbles. It delves into the nanoscale mechanisms of OnB, elucidating their role in mitochondrial metabolism (TFAM, PGC1alpha), hypoxic responses (HiF-1alpha), and their interplay in chronic pathologies including cancer and neurodegenerative disorders, amongst others. By understanding these dynamics and underlying mechanisms, this article aims to contribute to our accruing knowledge of OnB and the developing potential in ameliorating hypoxia- and metabolic stress-related conditions and fostering innovative therapies.
The Effect of Conductive Additive Morphology and Crystallinity on the Electrochemical Performance of Ni-Rich Cathodes for Sulfide All-Solid-State Lithium-Ion Batteries
Authors: Choi Jae Hong , Choi Sumyeong , Embleton Tom James , Ko Kyungmok , Saqib Kashif Saleem , Ali Jahanzaib , Jo Mina , Hwang Junhyeok , Park Sungwoo , Kim Minhu , Hwang Mingi , Lim Heesoo , Oh Pilgun
Published: December 2023

Sulfide electrolyte all-solid-state lithium-ion batteries (ASSLBs) that have inherently nonflammable properties have improved greatly over the past decade. However, determining both the stable and functional electrode components to pair with these solid electrolytes requires significant investigation. Solid electrolyte comprises 20–40% of the composite cathode electrode, which improves the ionic conductivity. However, this results in thick electrolyte that blocks the electron pathways in the electrode, significantly lowering the electrochemical performance. The application of conductive carbon material is required to overcome this issue, and, hence, determining the carbon properties that result in the most stable performance in the sulfide solid electrolyte is vital. This study analyzes the effect of the cathode conductive additive’s morphology on the electrochemical performance of sulfide electrolyte-based ASSLBs. Carbon black (CB) and carbon nanotubes (CNTs), which provide electron pathways at the nanoscale and sub-micron scale, and carbon nanofiber (CNF), which provides electron pathways at the tens-of-microns scale, are all tested individually as potential conductive additives. When the CNF, with its high crystallinity, is used as a conductive material, the electrochemical performance shows an excellent initial discharge capacity of 191.78 mAh/g and a 50-cycle capacity retention of 83.9%. Conversely, the CB and the CNTs, with their shorter pathways and significantly increased surface area, show a relatively low electrochemical performance. By using the CNF to provide excellent electrical conductivity to the electrode, the polarization is suppressed. Furthermore, the interfacial impedance across the charge transfer region is also reduced over 50 cycles compared with the CB and CNT composite cells. These findings stringently analyze and emphasize the importance of the morphology of the carbon conductive additives in the ASSLB cathode electrodes, with improvements in the electrochemical performance being realized through the application of long-form two-dimensional crystalline CNFs.
Nutritional Balance Matters: Assessing the Ramifications of Vitamin A Deficiency on Poultry Health and Productivity
Authors: Shastak Yauheni , Pelletier Wolf
Published: December 2023

Vitamin A, a critical micronutrient, plays a vital role in maintaining poultry health and maximizing productivity. This comprehensive review paper conducts a thorough analysis of the consequences of vitamin A deficiency in domestic fowl. It delves into the physiological functions of vitamin A and investigates how hypovitaminosis A impacts growth, immune function, reproduction, and overall poultry performance. Additionally, the review explores effective strategies for preventing and managing vitamin A deficiency, such as dietary adjustments and supplementation, while addressing the specific requirements for vitamin A intake. The implementation of these strategies holds immense importance in optimizing poultry management practices and achieving peak performance in poultry production. A profound understanding of the prevalence and factors contributing to clinical and subclinical vitamin A deficiency in domestic fowl is essential for ensuring the efficiency of poultry farming operations. Recognizing the pivotal role of vitamin A and applying the appropriate measures empowers poultry farmers to enhance the health outcomes and overall performance of their flocks.
Chlorophyll Sensitization of TiO2: A Mini-Review
Authors: Fuziki Maria E. K. , Tusset Angelo M. , dos Santos Onélia A. A. , Lenzi Giane G.
Published: December 2023

Recent studies have shown that chlorophyll sensitization can improve the performance of semiconductors like TiO2 in photocatalytic reactions and light-harvesting technologies, such as solar cells. Faced with the search for renewable energy sources and sustainable technologies, the application of this natural pigment has been gaining prominence. The present work addresses some of the main possibilities of chlorophyll-TiO2 combination, presenting the most relevant aspects affecting chlorophyll extraction and TiO2 sensitization.