bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, Optimization and Evaluation of Intranasal Nanotherapeutic of Atypical Antipsychotic Drug
Authors: PONDURI TEJA KUMAR , GUNTUPALLI CHAKRAVARTHI , JEGANATHAN BALAMURUGAN
Published: December 2023

Objective: The current study manifests the successful optimization and delivery of chitosan nanoparticles utilizing the nasal route to overcome inherent issues of ziprasidone hydrochloride, an atypical antipsychotic drug to curtail its bioavailability problems.Materials & Methods: Chitosan nanoparticles were prepared by ionic gelation technique and optimized using Box–Behnken design. In vitro drug release kinetics and ex vivo nasal permeation potential were determined.Results & Discussion: Chitosan nanoparticles exhibited a mean particle size of 153.8 ± 13.3 nm, a mean polydispersity index of 0.433 ± 0.15; an Entrapment Efficiency of 87.3 ± 3.62%, and a Drug loading capacity of 8.7 ± 0.25%. Transmission electron microscopy examinations revealed spherical particle size with uniform drug distribution. The physicochemical stability of nanoparticles was evaluated for 12 weeks, and they showed good stability at 25 ± 2°C/60 ± 5% RH. In vitro release studies established the supremacy of nanoparticles compared to drug suspension with cumulative drug release of 89.93% in pH 6.4 and 87.16% in pH 7.4. Ex vivo nasal permeation studies revealed a 5.26-fold increment in nasal permeation by nanoparticles, and the cumulative amount of drug permeated through nasal mucosa from nanoparticles was 2.58 ± 0.13 µg/cm2 × 10–2 compared to 1.02 ± 0.091 µg/cm2 × 10–2 from the drug suspension.Conclusion: Thus, in vitro and ex vivo results from nanoparticles showed remarkable potential in improving solubilization fate and nasal permeation of ziprasidone, thereby leading to prospective in vivo fate in enhancing brain delivery of ziprasidone.
A Walker’s paradise ain’t a driver’s hell: Evaluating the causal effect of temporary road pedestrianization on traffic conditions of surrounding roads
Authors: Parady Giancarlos , Chikaraishi Makoto , Oyama Yuki
Published: December 2023

This study uses a natural experiment approach to evaluate the causal effect of three regular road pedestrianization schemes in Central Tokyo on traffic conditions in surrounding areas. Cross-sectional traffic flow data collected by the Metropolitan Police Department via traffic counters was used as the dependent variable and causal effect evaluation was done via a difference-in-differences (DID) approach, where the temporal pedestrianization of a street was used as the treatment of interest. We take advantage of (1) the variability in pedestrianization execution days and (2) the seasonal variability in pedestrianization time periods, to define the natural experiments. Furthermore, three different buffer areas of 500m, 750m and 1000m were used to evaluate the sensitivity of effect estimates to the definition of the impact area. Results suggest that irrespective of buffer size, the impact of temporal road pedestrianization on cross-sectional traffic flow of surrounding roads is negligible. Point estimates of treatment effect magnitudes across all models are small (ranging from − 4.8–6.9%) and estimated with high degrees of uncertainty, with most confidence intervals including zero. As such, results do not show evidence of practically important increases in traffic flow in the surrounding areas of pedestrianized roads and point to some degree of “traffic evaporation” likely resulting from drivers’ behavioral adaptation.
‹Ich machʼ mir die Welt, widdewidde wie sie mir gefällt›
Authors: Knaus Thomas , Schmidt Jennifer
Published: December 2023

Kommunikation ist grundlegende Voraussetzung für gesellschaftliche Handlungsfähigkeit. Aufgrund des digitalen Wandels kommunizieren Individuen nicht nur vermehrt mit und innerhalb digitaler Medien, sondern können sich auch zunehmend mittels der Gestaltung medialer und digitaler Artefakte artikulieren. In diesem Beitrag widmen wir uns dem Gestalten von Medien und Technik als erweiterte Form menschlicher Artikulation. Im Rahmen einer medienethnografischen Studie auf Basis des Frankfurt-Dreiecks als Referenzrahmen spürten wir den neuen Artikulationsformen nach, die digitale Medien und Technik anbieten. Die Auswertung zeigt, dass diese neuen Artikulationsformen von den meisten Proband:innen (noch?) nicht umfänglich genutzt werden – zumindest nicht in allen möglichen Dimensionen. Technische Artikulationsfähigkeit als Erweiterung individueller Handlungskompetenz ist offenbar keine ‹angeborene› menschliche Befähigung, sondern eine Kompetenz, die erlernt werden kann – etwa wie eine Sprache oder ein Musikinstrument. Wie auch Medienbildung können technische Artikulationsfähigkeiten pädagogisch gefördert werden – gleichermassen sollten sie es auch. Denn in einer digitalen Welt dient die pädagogisch angeleitete Ausprägung von Artikulationsfähigkeiten nichts Geringerem als dem Erhalt gesellschaftlicher Handlungsfähigkeit. In der praktischen Arbeit in Makerspaces konnten wir beobachten, dass gerade die handlungsorientierten Ansätze Tinkering, Coding, Making oder Hacking zur gezielten Förderung der in diesem Beitrag exemplarisch identifizierten Artikulationsformen beitragen können.
BioTinkering – Biologie als faszinierendes Making-Thema in den Naturwissenschaften
Authors: Furrer Florian , Schläpfer-Miller Juanita , Spieler Bernadette , Dahinden Manuela
Published: December 2023

BioTinkering als Making-Aktivität in der Biologie begeistert Schüler:innen für die Pflanzenwelt und kann den naturwissenschaftlichen Unterricht durch überfachliche, digitale, prozessbasierte und produktorientierte Projektarbeiten bereichern. Dieser Artikel stellt Making-Aktivitäten im Themenbereich Pflanzenbiologie vor und diskutiert deren Kompetenzorientierung im Rahmen des Schweizerischen Lehrplan 21. Da sich BioTinkering anhand verschiedener Bereiche konstituiert, kann damit eine Vielzahl von Kompetenzen geschult werden. Im Artikel werden zur Vermeidung von Missverständnissen aufgrund der Multidisziplinarität eingangs Begriffsklärungen gegeben. Darauf folgend stellen wir Vorteile und Herausforderungen in Form von drei Thesen vor. Diese beinhalten (1) den Bezug von BioTinkering zum traditionellen naturwissenschaftlichen Unterricht, (2) die Thematisierung der Komplexität und des Zeitbedarfs sowie (3) die Förderung überfachlicher Kompetenzen. Im Anschluss diskutieren wir die Entwicklung und Erprobung von BioTinkering-Aktivitäten durch das CreativeLabZ des Zürich-Basel Plant Science Centers und stellen einen Leitfaden zur Anleitung von BioTinkering-Aktivitäten vor. Die Evaluationsresultate zeigen, dass BioTinkering sowohl für Lehrpersonen als auch für Schüler:innen interessant und kompetenzerweiternd ist.
Typological Features of Historical Myth
Authors: Artiukh Vyacheslav
Published: December 2023

The article constructs an image of the modern historical myth based on the ideas about the constant presence of mythical structures in human consciousness and experience. It is noted that the historical myth is well fixed at the level of perception of the past by non-specialized forms of consciousness of the average person, i.e. at the level of his/her historical memory. The very image of the historical myth appears as a set of such structures of mythical experience as mythical substance, sacrum, mythical arche, mythical time, and mythical space.
Mythical substance (essence) is the very phenomenon of the national, which is identically "poured" throughout the entire temporal existence of the nation.
Mythical arche is the origins, beginnings, and history of the origin of phenomena, objects, and customs. Any myth, in fact, speaks of the origins or what was in the beginning.
The model of mythical time is when, on one plane, it is profane time and it is perceived as flowing from the past to the future through the present, that is, it has a direction. On another plane, this time is sacred. This is the First Time when the archaea were created, and therefore it precedes the beginning of the counting of profane, empirical time. Sacred time can penetrate profane time as arche, for example, through the staging of the events of the sacred First Age.
The sacred is the experience of the sacred through which significant historical objects are perceived; then, while retaining their own nature, they appear fundamentally different from other historical objects of the everyday profane world.
Mythical space is not imagined in the abstract; it is combined with its content, i.e. historical events and facts. In addition, space in mythical perception is not a continuous unity; on the contrary, it is discontinuous. It consists of sacred objects and places.
Stages of the Life and Work of Anna Zatyrkevich-Karpynska
Authors: Lobko Nataliia , Kartava Karina
Published: December 2023

The article examines the main stages of the life and work of the outstanding Ukrainian artist, teacher, and theater actor Hanna Petrivna Zatyrkevich-Karpynska. The sources of writing the article are materials from periodicals, memories of her contemporaries, and materials from the Romny Museum of Local History.
Hanna Petrivna was born on February 20, 1855, in the noble family of the Kovtunenkos in the town of Srybny, Prylutsky District. At first, she participated in amateur performances. Since 1883, Hanna Petrivna Zatyrkevich began to perform with luminaries of the Ukrainian theater and their colleagues. She worked in professional Ukrainian theaters under the leadership of M. Kropyvnytskyi, M. Starytskyi, M. Sadovskyi, M. Starytskyi, P. Saksaganskyi, and I. Kavaleridze.
It was found that the factors that influenced her development as an actress, in particular, were her environment – a serf nanny and peasants with whom she communicated all her life. Her parents and studies at the Kyiv Institute of Noble Girls contributed to her interest in the theater. During her almost forty years of work in the theater, H. Zatyrkevich-Karpynska played about 130 roles and created a whole gallery of the most diverse and unsurpassed stage images. She was famous as a comical, characteristic actress. Her work and talent contributed to the formation of the Ukrainian National Theater.
The outstanding actress educated a whole constellation of students, most of whom became leading masters of the Ukrainian theater.
She spent the last years of her life in the city of Romny, where she took an active part in the theater created there. H. Zatyrkevich-Karpynska is buried in Romny Central Cemetery.
Hydropriming improves seed germination in horned melon (Cucumis metuliferus E. Mey. Ex Naudin) landraces
Authors: Mutetwa Moses , Chaibva Paul , Chagonda Ignatius , Makuvaro Veronica , Mtaita Taurira , Ngezimana Wonder , Masaka Johnson , Manjeru Pepukai
Published: December 2023

The global popularity of horned melon highlights the need of sound crop establishment processes, since uniform and quick seed germination has a substantial influence on crop yield and quality. Using a Completely Randomised Design (CRD) with a factorial structure, the effects of hydro priming durations (0, 8, 16, 24, 32, and 40 h) on seeds of two horned melon landrace (L1&L2) were investigated. Hydro priming had significant (P>0.05) influence on several germination indices (germination percentage, relativized percentage, mean germination rate, germination index, synchronization, duration to 50 % germination, mean daily germination, peak value, and germination value). Among the germination indicators tested, landrace (L2) exhibited a considerably stronger germination response than L1. The findings also reveal a curvilinear relationship between priming length and germination percentage, with 24 hours being greatest proportionately. The mean germination rate, germination index, mean daily germination, peak value of germination, and germination value all rose as the hydro priming duration increased. Primed seeds germinated more quickly than unprimed ones. With increasing priming duration, the synchronization index fell linearly. The interaction between landraces and hydro priming was not significant (P>0.05) for final seed germinated, relativized germination, and synchronization indices, but it had a significant impact on all other indices. Because the efficacy of hydro priming tends to lessen with extended soaking, we recommend using it for a maximum of 32 hours. Future study should concentrate on alternative priming chemicals and the applicability of various priming solutions for various agroecosystems
Chemical composition of summer truffle (Tuber aestivum Vittad.) from Bosnia and Herzegovina
Authors: Ljubojević Srđan , Vasilišin Ladislav , Vučić Goran , Velemir Ana
Published: December 2023

Ascocarps of summer truffle (Tuber aestivum Vittad.) were found in natural oak and beech forests on calcareous soils, at altitude of 840–850 m, near the town of Šipovo in Bosnia and Herzegovina (B&H), with the help of trained dogs.

 Until now, no one in B&H has researched the chemical composition of summer truffle. The aim of the work is to analyze nutritional value, elemental composition, and the assortment of fatty acids in the freshly collected ascocarps and to compare achieved results with the results from the literature related to the summer truffle ascocarps found in some other locations, then with the ascomata of other species of truffles, and with the fruiting bodies of some above-ground edible mushrooms.

Chemical analysis showed that Tuber aestivum contains about 75.5 % water and about 25.5 % dry matter. The most common group of compounds were carbohydrates, followed by proteins, while the mineral component and fats were much less presented. Among analyzed elements, the most prevalent was potassium with an average concentration of 26,409 mg/kgDW and the least represented was lead with an average concentration of 0.45 mg/kgDW. The main part of the mineral spectrum consisted of three elements: K, P and Ca, with a share of 95.3 %. In ascocarps of summer truffle, 24 fatty acids were detected, of which 13 were saturated and 11 unsaturated. The ratio of saturated to unsaturated fatty acids was 58.34 % to 41.66 %. The most common among saturated fatty acids was palmitic with a share of 25.89 %, while the most common unsaturated fatty acid was elaidic with a share of 28.17 %. No ingredients have been found in the fruiting bodies that would make them unfit for human consumption in any way
Veterinarian as an expert advisor: improving the quality of veterinary services and scientific research
Authors: ANDRZEJ CDZIKOWSKI
Published: December 2023

Veterinary surgeons often provide professional veterinary advice to both their colleagues, scientists, and lay clients. A number of them give advice unwittingly, and are unaware of the legal consequences of their actions. This analysis investigates veterinary advisorship from a comparative perspective. Ethical and legal analysis, and interpretation is performed. Essential types of veterinary counseling are indicated: advice provided by a veterinarian to another veterinarian, and provided by a veterinarian to a lay client. Veterinary advice in scientific research is a mixed type. Legal and deontological relevant factors of counseling, and consultants’ liability are identified. The wide range of responsibility, and liability of veterinary consultants is demonstrated. A veterinary counselor may be subject to various types of civil liability in relation to the person seeking advice, as well as to third parties. It is argued that an explicit, or implicit advisory clause in a contract, or an independent consulting agreement may be concluded, with the special regime of liability for veterinary advisorship. The conclusion is that – despite the fact that scope and liability differ in the discussed types of advisorship – the connecting factors are: specialist knowledge, which as advice or information is provided by a specialist in relation to a non-specialist, as well as the obligation to respect professional veterinary ethics.
SUBAŞI, Ömer, (2021), Moğollarda Kadın, Evlilik ve Dış Siyaset, Selenge Yayınları, İstanbul. ISBN: 978-625-74-5926-6, 1. Baskı, 344 s.
Authors: KÖSE Bayram Arif
Published: December 2023

Yazarın tanıtıma konu olan eseri de yine kadın temalı olup okuyucuyu orta çağın kadîm milletlerinden olan Moğollar dönemine götürmektedir. Kadına ayrı bir değer verdiğini gördüğümüz bu sıra dışı topluluk özellikle Cengiz Han döneminden beri çıkardığı yasalarla kadının toplumsal statüsünü ve siyasi mevkiini belli bir seviyeye çıkarmıştır. Genelde çok eşli bir aile yapısı benimsemelerine rağmen eşlerine gösterdikleri ilgi dikkate şayandır. Giyimleri, ziynetleri, süs eşyaları, aile içindeki konumu, göç esnasındaki rolü, savaşlardaki fedakarlıkları ve belki de en ilginci dış politikadaki etkileri Moğol kadınını günümüz de dahi ilgi odağı yapmaktadır. Bu ilgiden yola çıkılarak hazırlanan “Moğollarda Kadın, Evlilik ve Dış Siyaset” adlı eser sadece Moğol kadını hakkında bilgi vermekle kalmamış, orta çağ boyunca çeşitli devlet, hanedan hatta klanların kadına bakışı hakkında dahi zengin içerikli malumatları kapsamıştır.
Yaşam Çiçeği ve Osmanlı Cami Mimarisine Yansımaları
Authors: GÖKLER Burak Muhammet
Published: December 2023

İnsanoğlu duygusunu, düşüncesini veya bir nesneyi tanımlaması için yaşadığı süreç içerisinde çeşitli semboller kullanmıştır. Yaşanılan her dönemde farklı kültür ve amaçları yansıtmak amacıyla tercih edilen semboller, dünya sanatında önemli bir yer teşkil etmektedir. Kullanılan bu semboller bazen inancı temsil ederken bazen gücü veya kutsiyet atfedilen unsurları kapsamaktadır. Bu doğrultuda tarihsel süreç içerisinde var olan devletler kendilerine özgü semboller oluşturduğu gibi dünya sanatı için ortak semboller de benimsenmiştir. Hayat ağacı dünya sanatında ortak sembollerden birisi olarak kabul edilmektedir. Farklı varyasyonları söz konusu olsa da hayat ağacı olarak karşımıza çıkmaktadır. Benzer bir husus gücün simgesi konumunda olan aslan, kartal gibi yırtıcı hayvanlar ve ejder gibi fantastik figürlerde göstermektedir. Bu motifler de işleniş açısından kültürden kültüre farklılıklar ortaya koyabilir. Belirtilen semboller dışında Asya, Afrika ve Avrupa kıtasında karşılaşılan, verilişi, ortaya konuluşu ve işlenişi bakımından değişlik yapılamayan simgelerin başında “Yaşam Çiçeği” gelmektedir. Evrenin ve sonsuzluğun, kusursuzluğun, yaratılışın simgesi olan geometrik kurgu dünyanın ortak motiflerinden birisidir. Türk-İslam Sanatı süslemesinde rozet, çiçek, gülbezek, yıldız gibi farklı isimler ile adlandırılan “yaşam çiçeği” motifinin manası, ortaya çıkışı, hangi medeniyetlerde görüldüğü değerlendirilerek Osmanlı mimarisine nasıl yansıdığı ve işlendiği konusu aydınlatılmaya çalışılacaktır.
Doğu Türkistan’dan 1949 Büyük Göçü ve Erkin Alptekin’in Kısa Tercüme-i Hâli
Authors: KUL Ömer
Published: December 2023

949 yılında Çin’de Mao Ze-dong liderliğinde Komünistler iktidara gelince Doğu Türkistanlı ileri gelenler ülkeden ayrılmak zorunda kalmıştır. Zikredilen dönemde henüz 12 yaşında olan Erkin Alptekin ise göçe ailesinden önce başlamış, Türkiye’ye yerleşmesi sonucunda ise kendisini zorluklarla geçecek bir hayat mücadelesinin içerisinde bulmuştur. Bu çalışma ile Erkin Alptekin’in ailesi, doğumu, çocukluğu, evlenmesi, göç yolculuğu, Türkiye’ye yerleşmesi, eğitimi, mesleki yaşantısı yanında Doğu Türkistan davasını Batı ülkelerinde tanıtma mücadelesi ortaya konulmaya çalışmıştır. Bununla birlikte Erkin Alptekin’in kurduğu veya kurulmasında etkin rol aldığı sivil toplum kuruluşları yanında kaleme aldığı kitap, makale, katıldığı konferanslar ve hakkında yazılanlar bu çalışma ile değerlendirilme gayretinde olunmuştur. Bu çalışmada ayrıca, Erkin Alptekin ile yapılan görüşmeler esas alınarak 85 yıllık hayatı ve 1949 yılında Doğu Türkistan’dan göçü genel hatlarıyla değerlendirilmiştir.
Türk Edebiyatında Nur-ı Muhammedî Konulu Eserler ve Çağatayca Nur-name – 2
Authors: ÖLKER Perihan
Published: December 2023

Nur-ı Muhammedî ya da Hakikat-i Muhammediye olarak bilinen kavram tasavvufta ilk yaratılan varlığa işaret etmektedir. Felsefi ekollerin etkisiyle ortaya çıkan bu anlayışa göre kâinat bu nurdan yaratılmıştır. Bu nur, peygamberden peygambere intikal etmiş, asıl olarak Hz. Muhammed (s.a.v.)’de vücut bulmuş, velâyet yoluyla aktarılagelmiştir ve sayesinde de evren varlığını sürdürmektedir. Tasavvufi eserlerde sıklıkla bu kavram ele alınmaktadır ancak 17. yüzyıldan itibaren adı Nur-name olan ve sadece Nur-ı Muhammedî kavramının anlatıldığı mensur eserler görülmektedir. Bugüne kadar Osmanlı sahasında Cafer Iyanî Bey ve Mustafa Takî Efendi tarafından yazılan Nur-nameler tespit edilmiş ve yayımlanmıştır. Ancak Çağatay sahasında son dönem Çağatay Türkçesiyle yazılmış çok sayıda mensur Nur-name karşımıza çıkmaktadır. Bilhassa Çağatay sahasında meslek risalelerinin yer aldığı mecmualar, fütüvvetnameler, içerisinde tespit edilen Nur-nameler ahilik kültürünün önemli bir parçası olarak yerini bulmuştur. Bu çalışmada Nur-ı Muhammedî kavramı ele alınmış; Osmanlı Türkçesi ve Çağatay Türkçesiyle yazılmış Nur-nameler tanıtılarak Koyunoğlu Şehir Müzesi ve Kütüphanesi’nde 13758 arşiv numaralı Çağatayca Nur-name üzerinde durulmuştur. Mensur eserin çeviri yazıyla aktarımının yanı sıra Türkiye Türkçesine aktarımı yapılmış, dikkati çeken dil ve yazım unsurlarına değinilmiş ve bu doğrultuda eserin klasik dönem sonrası Çağatay Türkçesiyle yazıldığı da ortaya konmuştur.
Language Policy in Turkic States and Societies Historical Aspect
Authors: İBRAHİMOV Elçin
Published: December 2023

The roots of the communication history of the Turkic language, which has a history of at least 1300 years as a written language, are, of course, much older. If we take into account the features of the words in the language of the Orhon-Yenisey monuments, which are the first written sources, and the similarities of words in other languages, we see that the Turkic language has a history of four to five millennia as a language of communication. The Turkic language, whose origin goes back thousands of years, has been influenced by many languages as a result of the cultural, social, and political relations of Turks with other nations. The settling of large territories by Turks, leading a sedentary and nomadic life, constantly migrating for new lands, and coming into contact with many peoples against the background of these events led to the contact of the Turkic language (the languages of the Turkic-speaking peoples and tribes) with many related and unrelated languages. As a result of these relations, sometimes the Turkic language influenced these languages from the lexical and even grammatical aspects, and sometimes, on the contrary, it borrowed words from those languages. In this research article, we will try to talk about the language policy in the Turkic state and societies and the developments in the historical process.
Gülten Akın’ın Mevsimsel Döngüyü İşlediği Şiirlerinde Toplumcu Gerçekçi Poetikanın İzleri
Authors: DURMUŞ Gökay
Published: December 2023

Gülten Akın üretken bir şairdir. Bununla birlikte, yaklaşık 60 yıl süren sanat yaşamında Akın, üretmekle kalmamış; genelde sanat, özelde edebiyat ve şiir konusunda poetik düşünceler belirlemiş, bunları savunmuş ve genç şairler üzerinde etkili olmuştur. Söz konusu etki şairin toplumcu gerçekçi poetikaya bağlandığı süreçte daha yoğundur. Akın’ın mevsimsel döngüyü işlediği şiirleri bu konuda başlangıç noktası kabul edilmektedir. Çalışmada toplumcu gerçekçi poetikanın tarihçesi ve ilkeleri tahlil edildikten sonra, Akın’ın yaşamı ve şiiri üzerinde durulmuştur. Her iki başlık, Akın’ın çalışmaya konu olan şiirlerinde işlediği olgu ve durumlar için arka plan unsuru durumundadırlar. Daha sonra mevsimsel döngünün resmedildiği dört şiir ekseninde, Akın’ın bahsi geçen unsurları ne şekilde şiirleştirdiği belirlenmişti
Estudio arqueológico de la restauración del puente de Puente de Arco (Laviana, Asturias, España)
Authors: Carrocera Fernández Elías , Blanco Vázquez Luis
Published: December 2023

En este trabajo mostramos los resultados del estudio arqueológico realizado durante la restauración del puente de Puente de Arco (Laviana, Asturias). Como dato importante, podemos referirnos a que el puente actual es reflejo de la reconstrucción llevada a cabo a principios del siglo XIX, ya que desde 1795 se encontraba colapsado completamente. Asimismo, la actuación arqueológica nos permitió documentar un pequeño tramo del pavimento original de la primera fase de dicha reconstrucción.
Ética e integridade na pesquisa científica
Authors: Ribeiro Márcia Cristina Lacerda
Published: December 2023

A discussão sobre ética e integridade na pesquisa científica vem ganhando força no cenário mundial. Alguma engrenagem da máquina chamada ciência parece ter ruído, algo está fora do lugar. Avolumam-se os mais diferentes tipos de denúncias de más práticas dentro da comunidade científica, e a ciência é colocada sob suspeição. As entidades científicas levantam-se para coibir os abusos, criar regras claras e educar seus membros. Nosso objetivo é situar o debate e refletir sobre algumas questões que estão na ordem do dia: a inserção de informações falsas no currículo, especialmente aquele inserido na Plataforma Lattes, a autoria e coautoria, as retratações de artigos e seus correlatos, a pesquisa envolvendo seres humanos e as práticas de plágio. Partimos de uma investigação nos debates que têm movido a comunidade científica, utilizamos manuais de ética e conduta de instituições de pesquisa. Nós também analisamos algumas notas que nos chamaram a atenção em relação às infrações cometidas por pesquisadores, além de referências gerais sobre a temática. O resultado mostra um quadro preocupante, que aponta para uma necessária e urgente reflexão sobre o fazer da pesquisa nos mais diferentes cenários onde ela acontece.
Prevalence of Moderate to Severe Depressive Symptoms among Adults in the
UAE: A Cross-sectional Study
Authors: Salman Salman Mohamad , Alkhdour Abdel Rahman , Alsyouti Tala , Haddad Mohammad , Sharbatti Shatha Al
Published: December 2023

Objective::

The objectives of the study were to assess the prevalence of moderate to severe depressive symptoms among adults aged 18 years or older, assess
the relationship between the severity of depression and selected socio-demographic, psycho-social, lifestyle, and health-related factors, and identify
the determinants of moderate-to-severe depressive symptoms in the adult population of 18 years and older in the United Arab Emirates (UAE).

Methods::

This was a cross-sectional study conducted in the United Arab Emirates that targeted residents above 18 years of age. A research questionnaire was
developed and approved by three specialists in the field, along with the Patient Health Questionnaire-9 (PHQ9). The Chi-square test was used to
assess the association between variables, and multiple logistic regression analysis was used to find the predictive risk factors for moderate to severe
depressive symptoms.

Results::

The study encompassed a group of 562 participants, achieving a response rate of 97.33%. Initially, a Google Form was distributed electronically to
the entire participant pool; however, 15 individuals declined to participate, resulting in a final sample size of 547 (n). Amongst the variables that
showed significant prevalence of moderate to severe depressive symptoms were age (P <0.001), sex (P <0.001), marital status (P <0.001),
occupation classification (P <0.001), religiosity (P <0.001), education level (P <0.001), job stress (P <0.001), domicile and residence (P <0.001),
responsibility towards family (P <0.001), post-traumatic stress disorder (PTSD) (P <0.001), consumption of alcohol (P <0.001), coronavirus
disease pandemic (P <0.001), employment status (P = 0.002), family size (P = 0.001), and smoking (P = 0.004). Amongst the variables, the subgroups
that showed significant predictive factors of moderate to severe depressive symptoms were the ages between 18 and 25 years old (P = 0.01),
the female gender (P <0.001), and low levels of religiosity (P <0.001).

Conclusion::

The prevalence of moderate-to-severe depressive symptoms was 48% (n=260). In our study on the prevalence of depression, we have investigated
several predictive factors, including age, gender, religiosity, and a history of prior depression diagnosis. While numerous factors contribute to
depression, additional research is imperative to identify and validate additional predictive factors.
Global Epidemiology, Clinical Features, Diagnosis and Current Therapeutic
Novelties in Migraine Therapy and their Prevention: A Narrative Review
Authors: Ali Mohammad Daud , Gayasuddin Qur Fehmida , Alam Md. Sarfaraz , M. Alotaibi Nawaf , Mujtaba Md. Ali
Published: December 2023

Introduction::

The current article reviews the latest information on epidemiology, clinical features,
diagnosis, recent advancements in clinical management, current therapeutic novelties, and the prevention of
migraines. In a narrative review, all studies as per developed MeSH terms published until February 2023, excluding
those irrelevant, were identified through a PubMed literature search.

Methods::

Overall, migraine affects more than a billion people annually and is one of the most common neurological
illnesses. A wide range of comorbidities is associated with migraines, including stress and sleep disturbances.
To lower the worldwide burden of migraine, comprehensive efforts are required to develop and enhance
migraine treatment, which is supported by informed healthcare policy. Numerous migraine therapies
have been successful, but not all patients benefit from them.

Results::

CGRP pathway-targeted therapy demonstrates the importance of translating mechanistic understanding
into effective treatment. In this review, we discuss clinical features, diagnosis, and recently approved
drugs, as well as a number of potential therapeutic targets, including pituitary adenylate cyclase-activating
polypeptide (PACAP), adenosine, opioid receptors, potassium channels, transient receptor potential ion channels
(TRP), and acid-sensing ion channels (ASIC).

Conclusion::

In addition to providing more treatment options for improved clinical care, a better understanding
of these mechanisms facilitates the discovery of novel therapeutic targets.
Theoretical Evaluation of Oleocanthal Reactive Centers
Authors: Asgarshamsi Mohammad Hossein , Dehkordi Mehrdad Mohammadpour , Reza Nazifi Seyed Mohamad , Zborowski Krzysztof K.
Published: December 2023

Background:

Decarboxymethyl ligstroside aglycone (oleocanthal) is an essential component of olive
oil. It is therefore interesting to study its metabolism in the human body. In order to find the best possible starting
point for this metabolism, a theoretical study was carried out using DFT calculations and docking studies.

Methods:

The DFT, B3LYP/6-311++G** and the PCM solvation model calculations were used to study the initial
process of oleocanthal metabolism by the CYP1A2 enzyme. Structures of radicals formed by homolytic dissociation
of hydrogen atoms from the oleocanthal structure were obtained and their properties were studied. Several
parameters such as HOMO and LUMO energy gaps, Bond Dissociation Energy (BDE), hardness, and spin density
of possible oleocanthal radicals were taken into account. Docking of oleocanthal into an enzyme binding pocket
was also performed to locate the most probably metabolic site. Detailed analysis of the theoretical results allows
the determination of the most likely reaction sites in oleocanthal. The mode of binding of oleocanthal to the
CYP1A2 enzyme was also predicted.

Results:

The results of the molecular docking studies are in agreement with the calculated quantum parameters.
The theoretical predictions were compared with experimental data available in the scientific literature. A high
correlation between theoretical calculations and experimental data was observed. The most likely site of oleocanthal
metabolism was identified.

Conclusion:

The results of our research support the usefulness of theoretical calculations in predicting metabolic
pathways.
Liposomal Doxorubicin In vitro and In vivo Assays in Non-small Cell Lung
Cancer: A Systematic Review
Authors: Redruello-Guerrero Pablo , Córdoba-Peláez Paula , Láinez-Ramos-Bossini Antonio Jesús , Rivera-Izquierdo Mario , Mesas Cristina , Ortiz Raul , Prados Jose , Perazzoli Gloria
Published: December 2023

Background:

Liposomal Doxorubicin (Doxil®) was one of the first nanoformulations approved
for the treatment of solid tumors. Although there is already extensive experience in its use for
different tumors, there is currently no grouped evidence of its therapeutic benefits in non-small cell
lung cancer (NSCLC). A systematic review of the literature was performed on the therapeutic effectiveness
and benefits of Liposomal Doxil® in NSCLC.

Methods:

A total of 1022 articles were identified in publications up to 2020 (MEDLINE, Cochrane,
Web of Science Core Collection and Scopus). After applying inclusion criteria, the number was restricted
to 114, of which 48 assays, including in vitro (n=20) and in vivo (animals, n=35 and humans,
n=6) studies, were selected.

Results:

The maximum inhibitory concentration (IC50), tumor growth inhibition rate, response and
survival rates were the main indices for evaluating the efficacy and effectiveness of Liposomal DOX.
These have shown clear benefits both in vitro and in vivo, improving the IC50 of free DOX or untargeted
liposomes, depending on their size, administration, or targeting.

Conclusion:

Doxil® significantly reduced cellular proliferation in vitro and improved survival in vivo
in both experimental animals and NSCLC patients, demonstrating optimal safety and pharmacokinetic
behavior indices. Although our systematic review supports its benefits for the treatment of NSCLC,
additional clinical trials with larger sample sizes are necessary to obtain more precise clinical data on
its activity and effects in humans.
The Effect of Remote Ischemic Postconditioning on Quality of Life and Clinical Events after an Ischemic Stroke
Authors: Kerstens Thijs P. , Landman Thijs R.J. , Schoon Yvonne , Meijer Frederick J.A. , Warlé Michiel C. , de Leeuw Frank-Erik , Thijssen Dick H.J.
Published: December 2023

Objectives:

Repeated remote ischemic postconditioning (rIPostC) may be an easily
applicable treatment following ischemic stroke to improve quality of life (QoL) and clinical outcomes.
rIPostC consists of repeated, brief periods of limb ischemia (through inflation of a blood
pressure cuff), followed by reperfusion. This study investigated the 1-year follow-up of rIPostC
on QoL and clinical events.

Methods:

As part of a randomized controlled trial, adult patients with an ischemic stroke within
24 hours after onset of symptoms were randomized to repeated rIPostC or sham-conditioning.
rIPostC was applied twice daily during hospitalization (maximum of 4 days). QoL and patientreported
outcome measures (PROMs) were assessed at 12-week and 1-year follow-ups. Additionally,
we explored the effect of repeated rIPostC on clinical events (recurrent cerebrovascular
events, hospitalization, and mortality).

Results:

The trial was preliminarily stopped due to limitations in recruitment after the inclusion
of 88 patients (rIPostC: 40; sham-conditioning: 48) (70 years, 68% male). Questionnaires were
returned by 69 (78%) and 63 (72%) participants after 12 weeks and 1 year, respectively. The
median difference of the stroke-specific QoL between rIPostC and sham-conditioning was 0.05
(p =0.986) and -0.16 (p =0.654) after 12 weeks and 1-year, respectively. No significant effect of
rIPostC on the different domains of PROMs was detected. We observed no between-group differences
in recurrent cerebrovascular events, hospitalization, or all-cause mortality (Hazard Ratios
p >0.05).

Conclusion:

In this exploratory analysis, we observed no significant difference between repeated
rIPostC and usual care on QoL and clinical outcomes at 12 weeks and 1 year in patients with
an ischemic stroke.

Clinical Trial Registration Number:

NTR6880.
Albumin-Globulin Ratio and Common Carotid Artery Intima-Media Thickness in Patients with Ischemic Stroke
Authors: Han Qiao , You Shoujiang , Miao Mengyuan , Zheng Danni , Du Huaping , Sun Yaming , Zhai Wanqing , Zhong Chongke , Cao Yongjun , Liu Chun-Feng
Published: December 2023

Background:

The relationships between serum albumin, albumin-globulin (A/G) ratio,
globulin and atherosclerosis in acute ischemic stroke (AIS) remain uncertain. We investigated
the associations between serum albumin, A/G ratio, globulin levels and carotid atherosclerosis
in patients with AIS.

background:

The relationships between serum albumin, albumin-globulin (A/G) ratio, globulin and atherosclerosis in the setting of ischemic stroke are unclear.

Methods:

A total of 1,339 AIS patients were enrolled. Admission A/G ratio was divided into
quartiles, and serum albumin and globulin levels were also categorized. Carotid atherosclerosis
was detected through the assessment of common carotid artery intima-media thickness (cIMT),
and abnormal cIMT was characterized by mean and maximum cIMT values of ≥1 mm. We evaluated
the relationships between A/G ratio, albumin, globulin and abnormal cIMT, using multivariable
logistic regression models.

objective:

We aimed to evaluate the associations between serum albumin, A/G ratio, globulin levels and carotid atherosclerosis in patients with ischemic stroke.

Results:

In the multivariable-adjusted analysis, the highest A/G ratio quartile (Q4) was linked to
a 59% decreased risk of abnormal mean cIMT (OR 0.41; 95% CI 0.29-0.60) and a 58% decreased
risk of abnormal maximum cIMT (OR 0.42; 95% CI 0.30-0.60) when compared to the
lowest quartile (Q1), respectively. Moreover, decreased albumin and elevated globulin levels
were also associated with abnormal mean cIMT and maximum cIMT. In addition, the A/G ratio
provided supplementary predictive capability beyond the already established risk factors, and the
C-statistic of the A/G ratio for abnormal cIMT is larger than globulin (P <0.01).

Conclusion:

Decreased serum A/G ratio, albumin and elevated serum globulin were independently
associated with abnormal cIMT in AIS patients. Moreover, the A/G ratio appeared to
be a better predictor of abnormal cIMT.

result:

In the multivariable-adjusted analysis, the highest A/G ratio quartile (Q4) was associated with a 59% (OR 0.41; 95% CI 0.29-0.60) decreased risk of having abnormal mean cIMT and 58% (OR 0.42; 95% CI 0.30-0.60) decreased risk of having abnormal maximum cIMT in comparison to Q1, respectively. Moreover, decreased albumin and increased globulin levels were associated with abnormal mean cIMT and maximum cIMT. In addition, the A/G ratio provided incremental predictive capacity beyond established risk factors, and the C-statistic of A/G ratio for abnormal cIMT is larger than globulin (P<0.01).

conclusion:

Decreased serum A/G ratio, albumin and elevated serum globulin were independently associated with abnormal cIMT in patients with ischemic stroke. Moreover, the A/G ratio appeared to be a better predictor of abnormal cIMT.

other:

No
Association between Peripheral Arterial Lactate Levels and Malignant Brain Edema Following Endovascular Treatment for Ischemic Stroke
Authors: Wang Huiyuan , Yuan Ruozhen , Shen Panpan , Yu Xinyue , Chen Xinyi , Shang Yafei , Xu Jie , Tan Mingming , Zhang Sheng , Geng Yu
Published: December 2023

Aims:

To investigate the factors of postoperative malignant brain edema (MBE) in
patients with acute ischemic stroke (AIS) treated with endovascular treatment (EVT).

Background:

MBE is a severe complication following EVT for AIS, and it is essential to identify
risk factors early. Peripheral arterial lactate (PAL) levels may serve as a potential predictive
marker for MBE.

Objective:

To determine whether immediate postoperative PAL levels and the highest PAL level
within 24 hours of EVT are independently associated with MBE development in AIS patients.

Methods:

We retrospectively analyzed patients with AIS who underwent EVT from October
2019 to October 2022. Arterial blood was collected every 8 h after EVT to measure PAL, and
record the immediate postoperative PAL and the highest PAL level within 24 h. Brain edema
was evaluated using brain computed tomography scans within 7 days of EVT.

Results:

The study included 227 patients with a median age of 71 years, of whom 59.5% were
male and MBE developed in 25.6% of patients (58/227). Multivariate logistic regression analysis
showed that the immediate postoperative PAL (odds ratio, 1.809 [95% confidence interval (CI),
1.215-2.693]; p = 0.004) and the highest PAL level within 24 h of EVT (odds ratio, 2.259 [95%
CI, 1.407-3.629]; p = 0.001) were independently associated with MBE. The area under the curve
for predicting MBE based on the highest PAL level within 24 hours of EVT was 0.780 (95% CI,
0.711-0.849).

Conclusion:

Early increase in PAL levels is an independent predictor of MBE after EVT in AIS patients.
Diagnostic Concordance and Discrepancies in 3D TVUS and MRI of Congenital
Uterine Malformations across the ASRM 2016, ASRM 2021, ESHRE/ESGE
2016, and CUME 2018
Authors: Gürses Cemil , Kılıç Koray
Published: December 2023

Background::

The classification of Congenital Uterine Malformations (CONUTA) relies on coronal imaging of the uterus using 3D TVUS and MRI. In everyday
practice, radiologists and gynaecologists often struggle to confidently categorize CONUTA due to varying classification systems and the lack of
worldwide consensus.

Objectives::

The aim of this study was to evaluate the diagnostic concordance and discrepancies between two imaging techniques within the context of the
ASRM, ESHRE/ESGE, and CUME systems.

Methods::

Ninety-four patients suspected of having CONUTA underwent evaluation: 67 underwent 3D TVUS, 53 had MRI scans, and 34 were examined
using both imaging techniques.
An initial cross-listing table of ASRM, ESHRE/ESGE, and CUME was created, and a flowchart schema was used to define the type of congenital
uterine anomaly for each system
The prevalence of anomalies in each system was calculated, and Fleiss’ Kappa was used to assess and determine the level of agreement.

Results::

Class VI arcuate uterus was the most common form in ASRM 2016 and 2021, while the partially septate uterus predominated in the CUME 2018
and ESHRE/ESGE 2016 classification systems.

Conclusion::

There is no discordance between classification systems for all fusion defects and complete septate type of absorption defects. In the ESHRE/ESGE
system, nearly half of the abnormal uteruses were categorized as partially septate. However, the CUME system proved less effective in
distinguishing between normal and arcuate uteruses.
Inclusive Exploration of Harmonizing and Alternative Treatments for
Hypothyroidism
Authors: Lagah Jaspreet , Pal Rashmi Saxena , Lalitha Chaitanya Motamarri Venkata Naga , Pal Yogendra , Morya Sonia
Published: December 2023

:

A clinical syndrome known as hypothyroidism occurs due to a shortage of thyroid hormone
as a result of decreased production, abnormal distribution, or no action of thyroid hormones. The
most typical clinical symptoms included are dry skin, hair loss, weight gain, painful-prolonged periods,
infertility, balance problems, slow speech, bradycardia, hypothermia, fatigue, anxiety & depression,
joint pain, and indigestion. Basically, age, gender, the severity of the ailment, and a few other
factors affect the various signs and symptoms of hypothyroidism. The limitations of allopathic modalities
necessitate the investigation of alternative treatment options. Future healthcare initiatives for
the poor world will increasingly depend on CAM approaches to these concerns because lifestyle, diet,
obesity, lack of exercise, and stress are significant contributing factors to the development of hypothyroidism.
This review's objective is to provide information on herbs as well as complementary and
alternative medications which are grouped into five major domains: Biologically Based therapies,
Manipulative body-based therapies, Mind body-based therapies, and the whole Medical system.
These have traditionally been used to treat thyroid dysfunction. The distribution of diseases in emerging
nations is altering as a result of globalization. Hence the existing and potential roles of CAM
techniques in the general practice of medicine are illustrated in these approaches. Scientists are being
compelled to consider traditional herbal medical treatments and CAM therapy in order to combat
adverse medication occurrences, high treatment costs, and compliance problems thus described in
this review paper.
A Quantum-assisted Diagnostics Method for Intelligent Manufacturing
Authors: Sharma Vishal
Published: December 2023

 Present manufacturing machines have few methods to investigate machine
health. To minimize issues and enhance the correctness of machine decisions and
automation, machine health conditions require to be investigated. Therefore, the
evolution of a fresh investigating and diagnostics approach for additive manufacturing
machines is needed for better productivity in Industry 4.0. In the current chapter, an
intelligent technique for the condition monitoring of additive manufacturing (AM) is
described, where an accelerometer fitted on the extruder assembly is used to receive
vibration signals. The process errors with the printer were the worn-out timing belts
driving the extruder assembly. Quantum-based Support Vector Machine was simulated
to identify the 3D-printer status. The simulation outcomes presented here show that this
approach has better correctness as compared to the previous Support Vector Machine
techniques.
Harnessing Agro-based Biomass for Sustainable Thermal Energy Storage with Biochar Polymer Nanocomposites
Authors: Rao Kode Venkateswara
Published: December 2023

Food loss due to wastage is a severe issue for the entire world. Wastage
accounts for up to one-third of lost food output globally. Although there are various
ways to turn food waste into useful functional materials, landfilling is still a frequent
practice. This results in greenhouse gas emissions, which increase the already
significant greenhouse gas emissions linked to the agriculture sector. In this review, we
start by identifying multiple biomass sources and synthesis methods for biochar made
from biomass. This contains methods for the characterization of phase change polymer
nanocomposite materials impregnated with biochar. In order to compare the thermal
properties of phase change materials and gain an understanding of the various
biowastes, a comprehensive methodology was used.