bluuebunny/crossref_metadata_2025 huggingface dataset:
A Drug Safety Concept (I) to Avoid Polypharmacy Risks in Transplantation by Individual Pharmacotherapy Management in Therapeutic Drug Monitoring of Immunosuppressants
Authors: Wolf Ursula
Published: September 2023

For several, also vital medications, such as immunosuppressants in solid organ and hematopoietic stem cell transplantation, therapeutic drug monitoring (TDM) remains the only strategy for fine-tuning the dosage to the individual patient. Especially in severe clinical complications, the intraindividual condition of the patient changes abruptly, and in addition, drug-drug interactions (DDIs) can significantly impact exposure, due to concomitant medication alterations. Therefore, a single TDM value can hardly be the sole basis for optimal timely dose adjustment. Moreover, every intraindividually varying situation that affects the drug exposure needs synoptic consideration for the earliest adjustment. To place the TDM value in the context of the patient’s most detailed current condition and concomitant medications, the Individual Pharmacotherapy Management (IPM) was implemented in the posttransplant TDM of calcineurin inhibitors assessed by the in-house laboratory. The first strategic pillar are the defined patient scores from the electronic patient record. In this synopsis, the Summaries of Product Characteristics (SmPCs) of each drug from the updated medication list are reconciled for contraindication, dosing, adverse drug reactions (ADRs), and DDIs, accounting for defined medication scores as a second pillar. In parallel, IPM documents the resulting review of each TDM value chronologically in a separate electronic Excel file throughout each patient’s transplant course. This longitudinal overview provides a further source of information at a glance. Thus, the applied two-arm concept of TDM and IPM ensures an individually tailored immunosuppression in the severely susceptible early phase of transplantation through digital interdisciplinary networking, with instructive and educative recommendations to the attending physicians in real-time. This concept of contextualizing a TDM value to the precise patient’s condition and comedication was established at Halle University Hospital to ensure patient, graft, and drug safety.
Combining MSC Exosomes and Cerium Oxide Nanocrystals for Enhanced Dry Eye Syndrome Therapy
Authors: Tian Ying , Zhang Yiquan , Zhao Jiawei , Luan Fuxiao , Wang Yingjie , Lai Fan , Ouyang Defang , Tao Yong
Published: September 2023

Dry eye syndrome (DES) is a prevalent ocular disorder involving diminishe·d tear production and increased tear evaporation, leading to ocular discomfort and potential surface damage. Inflammation and reactive oxygen species (ROS) have been implicated in the pathophysiology of DES. Inflammation is one core cause of the DES vicious cycle. Moreover, there are ROS that regulate inflammation in the cycle from the upstream, which leads to treatment failure in current therapies that merely target inflammation. In this study, we developed a novel therapeutic nanoparticle approach by growing cerium oxide (Ce) nanocrystals in situ on mesenchymal stem cell-derived exosomes (MSCExos), creating MSCExo-Ce. The combined properties of MSCExos and cerium oxide nanocrystals aim to target the “inflammation-ROS-injury” pathological mechanism in DES. We hypothesized that this approach would provide a new treatment option for patients with DES. Our analysis confirmed the successful in situ crystallization of cerium onto MSCExos, and MSCExo-Ce displayed excellent biocompatibility. In vitro and in vivo experiments have demonstrated that MSCExo-Ce promotes corneal cell growth, scavenges ROS, and more effectively suppresses inflammation compared with MSCExos alone. MSCExo-Ce also demonstrated the ability to alleviate DES symptoms and reverse pathological alterations at both the cellular and tissue levels. In conclusion, our findings highlight the potential of MSCExo-Ce as a promising therapeutic candidate for the treatment of DES.
Three-Dimensionally Printed Vaginal Rings: Perceptions of Women and Gynecologists in a Cross-Sectional Survey
Authors: Junqueira Laura Andrade , Raposo Francisco José , Vitral Geraldo Sérgio Farinazzo , Tabriz Atabak Ghanizadeh , Douroumis Dennis , Raposo Nádia Rezende Barbosa , Brandão Marcos Antônio Fernandes
Published: September 2023

Three-dimensional printing technologies can be implemented for the fabrication of personalized vaginal rings (VRs) as an alternative approach to traditional manufacturing. Although several studies have demonstrated the potential of additive manufacturing, there is a lack of knowledge concerning the opinions of patients and clinicians. This study aimed to investigate the perception of women and gynecologists regarding VRs with personalized shapes. The devices were printed with different designs (traditional, “Y”, “M”, and flat circle) by Fused Deposition Modeling for a cross-sectional survey with 155 participants. Their anticipated opinion was assessed through a questionnaire after a visual/tactile analysis of the VRs. The findings revealed that most women would feel comfortable using some of the 3D-printed VR designs and demonstrated good acceptability for the traditional and two innovative designs. However, women presented multiple preferences when the actual geometry was assessed, which directly related to their age, previous use of the vaginal route, and perception of comfort. In turn, gynecologists favored prescribing traditional and flat circle designs. Overall, although there was a difference in the perception between women and gynecologists, they had a positive opinion of the 3D-printed VRs. Finally, the personalized VRs could lead to an increase in therapeutic adherence, by meeting women’s preferences.
Waveform Selection Based on Discrete Prolate Spheroidal Sequences for Near-Optimal SNRs for Photoacoustic Applications
Authors: Sun Zuwen , Baddour Natalie
Published: September 2023

Waveform engineering is an important topic in imaging and detection systems. Waveform design for the optimal Signal-to-Noise Ratio (SNR) under energy and duration constraints can be modelled as an eigenproblem of a Fredholm integral equation of the second kind. SNR gains can be achieved using this approach. However, calculating the waveform for optimal SNR requires precise knowledge of the functional form of the absorber, as well as solving a Fredholm integral eigenproblem which can be difficult. In this paper, we address both those difficulties by proposing a Fourier series expansion method to convert the integral eigenproblem to a small matrix eigenproblem which is both easy to compute and gives a heuristic view of the effects of different absorber kernels on the eigenproblem. Another important result of this paper is to provide an alternate waveform, the Discrete Prolate Spheroidal Sequences (DPSS), as the input waveform to obtain near optimal SNR that does not require the exact form of the absorber to be known apriori.
Chinee Apple (Ziziphus mauritiana): A Comprehensive Review of Its Weediness, Ecological Impacts and Management Approaches
Authors: O’Brien Ciara J. , Campbell Shane , Young Anthony , Vogler Wayne , Galea Victor J.
Published: September 2023

Ziziphus mauritiana Lam. (Rhamnaceae) (Chinee Apple, Indian Jujube, or Ber) is a significant woody weed in the drier tropics of northern Queensland, Western Australia, and the Northern Territory. Throughout these regions, its densely formed thickets influence the structure, function, and composition of rangeland ecosystems by outcompeting native pasture species. Despite this, the recent literature is heavily focused on the horticultural value of domesticated Ziziphus species in South Asia (China, India, and Pakistan), particularly its potential for poverty alleviation in arid or semi-arid areas. In fact, there has been comparatively little research undertaken on its invasiveness or associated ecological factors in pastoral contexts. Currently, the management of Z. mauritiana is limited to the application of synthetic herbicides or mechanical clearing operations. There is also considerable interest in the exploitation of host-specific, natural enemies (biological control agents, herbivorous insects, fungi, bacteria, or viruses) for limiting the vigour, competitiveness, or reproductive capacity of Z. mauritiana in northern Australia. The development of a “bioherbicide” in lieu of synthetic counterparts may foster a more resilient coexistence between agricultural systems and the natural environment owing to its reduced environmental persistence and increased target specificity. This review summarises the current literature on the weediness, ecological impacts, and current management of this problematic weed, thereby identifying (i) opportunities for further research and (ii) recommendations for improved management within its invasive range.
Genome-Wide Identification and Expression Analysis of MTP (Metal Ion Transport Proteins) Genes in the Common Bean
Authors: Yilmaz Hilal , Özer Göksel , Baloch Faheem , Çiftçi Vahdettin , Chung Yong , Sun Hyeon-Jin
Published: September 2023

MTP/CDF carriers, called metal ion transport proteins, act as substrates for the transmission of micronutrients such as iron (Fe), zinc (Zn), and manganese (Mn) to membrane carriers in plants. In this study, genome-wide analysis of the MTP gene family in the common bean genome, expression analysis of the PvMTP4, PvMTP5, and PvMTP12 genes after Fe and Zn treatments, and the effects of Fe and Zn applications on iron and zinc content were investigated. This study used common bean genotypes assumed to have high or low Fe and Zn accumulation ability. PvMTP genes were defined as containing conserved catalytic domains with molecular weights and protein lengths ranging from 41.35 to 91.05 kDa and from 369 to 813 amino acids (aa), respectively. As a result of the phylogenetic analysis, three main clusters containing seven subgroups were formed. In this study, the first characterization of the MTP gene family of beans was performed, and the responses of three different PvMTP genes in the Zn-CDF group to Fe and Zn applications were revealed. The obtained findings are thought to constitute pioneering resources for future research on common bean biofortification studies, plant breeding related to Fe and Zn, and the functional characterization of the MTP gene family.
Floral Aroma and Pollinator Relationships in Two Sympatric Late-Summer-Flowering Mediterranean Asparagus Species
Authors: Llorens Leonardo , Tomàs Joan , Ferriol Pere , García María Trinitat , Gil Lorenzo
Published: September 2023

This research delves into plant–pollinator relationships within the Mediterranean region, focusing on two synchronous and sympatric asparagus species: A. acutifolius and A. albus. For the first time, the floral scents of the genus Asparagus are reported. We investigate the volatile organic compounds (VOCs) present in their floral scents and their impact on pollinator attraction. Captured flower-emitted VOCs underwent solid-phase microextraction of headspace (SPME-HS) and gas chromatography and mass spectrometry (GC-MS) analysis. The investigation confirms distinctive aroma profiles for each species. A. albus predominantly emits benzene derivatives and sesquiterpenes, while A. acutifolius is characterized by carotenoid derivatives, monoterpenes, and sesquiterpenes. The only shared compounds between the two species are the sesquiterpenes (Z,E)-α-farnesene and (E,E)-α-farnesene. A positive correlation links peak floral aroma intensity (benzenoids in A. albus and ionones in A. acutifolius) with a higher pollinator visit frequency, emphasizing the critical role of intense floral scents in pollinator attraction. The study of reproductive aspects reveals almost complete gynodioecy in A. acutifolius, influencing unique dynamics for the two species. These adaptations hold significant importance within the Mediterranean ecosystem, particularly during the late dry summer period, when a limited number of plant species vie for a shared primary pollinator.
Early Detection of Phenotypic Diversity of Alfalfa (Medicago sativa L.) in Response to Temperature
Authors: Escobar-Gutiérrez Abraham J. , Ahmed Lina Q.
Published: September 2023

Climate change may have important consequences on plant distribution because local environments could change faster than the pace of natural selection and adaptation of wild populations and cultivars of perennial forages. Temperature is a primary factor affecting seed germination and primary heterotrophic growth processes. Medicago sativa (L.) is the most important forage legumes globally. The accelerated breeding of alfalfa cultivars adapted to new ranges of temperature could be necessary under most future climate scenarios. This work aims to explore the genetic diversity of a sample of accessions for responses to temperature during seed germination and seedling heterotrophic growth. Seeds or seedlings were placed in the dark under eight constant temperatures in the range of 5 °C to 40 °C. Germinated seeds were manually counted, while hypocotyl and radicle growth were estimated by using image analysis and curve fitting. Multivariate analyses highlighted links between responses and the origin of accessions. Variability was high, within and between accessions, for all the response variables. Accessions showed significant differences in their non-linear response curves in terms of germinability, germination rates and relative elongation rates. Nevertheless, differences were more noticeable in germination rations and rates compared to seedling heterotrophic growth. Consequently, these could be easier to use as early markers for alfalfa selection and breeding for the future.
The Potential Role of bZIP55/65 in Nitrogen Uptake and Utilization in Cucumber Is Revealed via bZIP Gene Family Characterization
Authors: Hua Bing , Liang Fei , Zhang Wenyan , Qiao Dan , Wang Peiqi , Teng Haofeng , Zhang Zhiping , Liu Jiexia , Miao Minmin
Published: September 2023

The bZIP (basic leucine zipper) proteins play crucial roles in various biological functions. Nitrogen (N) is an essential element for plant growth, especially in cucumber (Cucumis sativus) due to its shallow roots. However, the regulation of bZIP genes in cucumber nitrogen metabolism has not been studied yet. In this study, we identified a total of 72 bZIP genes (CsbZIPs) in the cucumber genome that could be classified into 13 groups. These genes were unevenly distributed on seven chromosomes, and synteny analysis showed that the CsbZIP genes were expanded in a segmentally duplicating manner. Furthermore, our genome-wide expression analysis suggested that CsbZIP genes had different patterns and that five CsbZIP genes were regulated by nitrogen treatment in both leaves and roots. Consistent with CsNPF, CsbZIP55 and CsbZIP65 were regulated by nitrogen treatment in leaves and roots. Moreover, the subcellular localization showed that CsbZIP55 and CsbZIP65 were specifically located in the nucleus, and the transcriptional activation assay showed that CsbZIP55 and CsbZIP65 have transcriptional activation activity. Additionally, in the CsbZIP55 and CsbZIP65 overexpression plants, most nitrogen-regulated CsNPF genes were downregulated. Taken together, our comprehensive analysis of the bZIP gene family lays a foundation for understanding the molecular and physiological functions of CsbZIPs.
Drought Resistant Resting Cysts of Paraphysoderma sedebokerense Preserves the Species Viability and its Virulence
Authors: Alors David , Boussiba Sammy , Zarka Aliza
Published: September 2023

The blastocladialean fungus P. sedebokerense is a facultative parasite of economically important microalgae and for this reason it has gained a lot of interest. P. sedebokerense has a complex life cycle which includes vegetative and resting stages. The resting cysts were assumed to play an essential role in survival by resisting drought, but this ability was never tested and the factors that trigger their formation were not evaluated. This study was aimed to induce resting cyst formation and germination in P. sedebokerense. At first, we tested the survival of P. sedebokerense liquid cultures and found that infectivity is retained for less than two months when the cultures were stored on the bench at room temperature. We noticed that dry cultures retained the infectivity for a longer time. We, thus, developed a method, which is based on dehydration and rehydration of the biomass, to produce, maintain, and germinate resting cysts of P. sedebokerense in both saprophytic and parasitic modes of growth. When the dry cultures were rehydrated and incubated at 30 °C, resting cysts asynchronously germinated after 5 h and the “endosporangium” was protruding outside of the cyst. Our method can be used to preserve P. sedebokerense for research purposes with the advantage of no need for expensive equipment.
Development and Characterization of a Molecularly Imprinted Polymer for the Selective Removal of Brilliant Green Textile Dye from River and Textile Industry Effluents
Authors: Luna Quinto Miguel , Khan Sabir , Vega-Chacón Jaime , Mortari Bianca , Wong Ademar , Taboada Sotomayor Maria Del Pilar , Picasso Gino
Published: September 2023

In this paper, we present an alternative technique for the removal of Brilliant Green dye (BG) in aqueous solutions based on the application of molecularly imprinted polymer (MIP) as a selective adsorbent for BG. The MIP was prepared by bulk radical polymerization using BG as the template; methacrylic acid (MAA) as the functional monomer, selected via computer simulations; ethylene glycol dimethacrylate (EGDMA) as cross-linker; and 2,2′-azobis(2-methylpropionitrile) (AIBN) as the radical initiator. Scanning electron microscopy (SEM) analyses of the MIP and non-molecularly imprinted polymer (NIP)—used as the control material—showed that the two polymers exhibited similar morphology in terms of shape and size; however, N2 sorption studies showed that the MIP displayed a much higher BET surface (three times bigger) compared to the NIP, which is clearly indicative of the adequate formation of porosity in the former. The data obtained from FTIR analysis indicated the successful formation of imprinted polymer based on the experimental procedure applied. Kinetic adsorption studies revealed that the data fitted quite well with a pseudo-second order kinetic model. The BG adsorption isotherm was effectively described by the Langmuir isotherm model. The proposed MIP exhibited high selectivity toward BG in the presence of other interfering dyes due to the presence of specific recognition sites (IF = 2.53) on its high specific surface area (112 m2/g). The imprinted polymer also displayed a great potential when applied for the selective removal of BG in real river water samples, with recovery ranging from 99 to 101%.
Experimental Analysis and Application of a Multivariable Regression Technique to Define the Optimal Drilling Conditions for Carbon Fiber Reinforced Polymer (CFRP) Composites
Authors: Molina-Moya Miguel Ángel , García-Martínez Enrique , Miguel Valentín , Coello Juana , Martínez-Martínez Alberto
Published: September 2023

Carbon fiber reinforced polymers (CFRPs) are interesting materials due to their excellent properties, such as their high strength-to-weight ratio, low thermal expansion, and high fatigue resistance. However, to meet the requirements for their assembly, the drilling processes involved should be optimized. Defects such as delamination, dimensional errors and poor internal surface finish can lead to the premature failure of parts when bolt-joined or rivet-connected. In addition, the characteristic anisotropy and heterogeneity of these materials, and the issues related to the temperature reached during drilling, make it difficult to obtain optimal cutting parameters or to achieve high material removal rates. This research focuses on the optimization of the CFRPs drilling process by means of experimental analysis—varying the feed and spindle speed—for two different types of commercial drills—a twist tool and a dagger tool. An automatic image processing methodology was developed for the evaluation of the dimensional accuracy and delamination of the holes. The optimization was carried out using a multi-objective regression technique based on the dimensional deviations, delamination and surface finish. The areas with favorable machining conditions have been delimited for both tools and the results indicate that the twist tool allows one to achieve more productive cutting conditions than the dagger tool, when the combination of low feeds and high spindle speeds are the conditions to be avoided.
Strategy for Constructing Phosphorus-Based Flame-Retarded Polyurethane Elastomers for Advanced Performance in Long-Term
Authors: Luo Yuxin , Geng Zhishuai , Zhang Wenchao , He Jiyu , Yang Rongjie
Published: September 2023

Polyurethane elastomer (PUE), which is widely used in coatings for construction, transportation, electronics, aerospace, and other fields, has excellent physical properties. However, polyurethane elastomers are flammable, which limits their daily use, so the flame retardancy of polyurethane elastomers is very important. Reactive flame retardants have the advantages of little influence on the physical properties of polymers and low tendency to migrate out. Due to the remarkable needs of non-halogenated flame retardants, phosphorus flame retardant has gradually stood out as the main alternative. In this review, we focus on the fire safety of PUE and provide a detailed overview of the current molecular design and mechanisms of reactive phosphorus-containing, as well as P-N synergistic, flame retardants in PUE. From the structural characteristics, several basic aspects of PUE are overviewed, including thermal performance, combustion performance, and mechanical properties. In addition, the perspectives on the future advancement of phosphorus-containing flame-retarded polyurethane elastomers (PUE) are also discussed. Based on the past research, this study provides prospects for the application of flame-retarded PUE in the fields of self-healing materials, bio-based materials, wearable electronic devices, and solid-state electrolytes.
Hydrogen Permeability of Polyamide 6 Used as Liner Material for Type IV On-Board Hydrogen Storage Cylinders
Authors: Dong Chufeng , Liu Yitao , Li Jiepu , Bin Guangfu , Zhou Chilou , Han Wulin , Li Xiang
Published: September 2023

As a commonly used liner material for fully reinforced, carbon-fiber-composite hydrogen storage cylinders, polyamide 6 (PA6) needs to meet the required hydrogen permeation index during use; otherwise, it may adversely affect the safe use of hydrogen storage cylinders. The hydrogen permeability of PA6 under different temperatures and pressures was tested, and the variations in its hydrogen permeability were investigated. Additionally, the hydrogen permeability of PA6, polyamide 11 (PA11), and high-density polyethylene (HDPE) at a temperature of 288 K and a pressure of 70 MPa was tested, and the differences in hydrogen permeability among these commonly used liner materials for type IV on-board hydrogen storage cylinders were studied. The results reported herein indicate that both the hydrogen permeability and diffusion coefficient of PA6 increase with rising test temperature but decrease with increasing pressure. The solubility coefficient of PA6 shows no significant change with varying test temperatures and pressures. At a test temperature of 288 K and a pressure of 70 MPa, among the three materials, PA6 has slightly stronger hydrogen permeation resistance than PA11, while HDPE has the least resistance. These research findings can serve as valuable reference data for evaluating the hydrogen permeability of liner materials.
Characterization of Polymeric Composites for Hydrogen Tank
Authors: Gul Waseem , Xia Yu En , Gérard Pierre , Ha Sung Kyu
Published: September 2023

Carbon neutrality has led to a surge in the popularity of hydrogen tanks in recent years. However, designing high-performance tanks necessitates the precise determination of input material properties. Unfortunately, conventional characterization methods often underestimate these material properties. To address this limitation, the current research introduces alternative designs of ring tensile specimens, which enable accurate and reliable characterization of filament-wound structures. The advantages and disadvantages of these alternative designs are thoroughly discussed, considering both numerical simulations and experimental investigations. Moreover, the proposed ring tensile methods are applied to characterize thermoplastic composites for hydrogen storage tanks. The results indicate that the mechanical strengths and stiffness of carbon fiber-reinforced thermoplastic Elium® 591 composites closely match those of epoxy-based composites. This newfound accuracy in measurement is expected to contribute significantly to the development of recyclable hydrogen tanks.
Tracking Resistance in Polymeric Insulation Materials for High-Voltage Electrical Mobility Applications Evaluated by Existing Test Methods: Identified Research Needs
Authors: Riba Jordi-Roger , Moreno-Eguilaz Manuel , Bogarra Santiago
Published: September 2023

With the increasing electrification of the transportation and mobility sectors, polymer insulation materials are inevitably exposed to harsher environments, including exposure to contamination, wide temperature ranges, operation at higher voltages and switching frequencies, and low-pressure environments. This paper reviews the tests to characterize the polymeric materials used in insulation systems for electric mobility applications, focusing on resistance to tracking. This paper also reports on the limitations of existing standard test methods and identifies the challenges and research needs to meet the increasing demands of the electric mobility industry. To this end, an evaluation of the scientific and technological state of the art is carried out through the analysis of theses, research articles, technical reports, manufacturers’ datasheets, international standards, and white papers.
Microstructure and Water Retention Kinetics in Autogenous Cured Self-Compacting Concrete Blends Using Super Absorbent Polymer
Authors: Laila Lija Rajamony , Karmegam Aarthi , Avudaiappan Siva , Flores Erick I. Saavedra
Published: September 2023

This research aimed to determine how a super absorbent polymer affects the microstructural characteristics and water retention kinetics of a new composite made by substituting granite pulver (GP) and fly ash (FA) for cement. Understanding the mechanics of water movement is crucial for comprehending the effectiveness of autogenous curing. Several experiments were conducted to analyze the water mitigation kinetics of super absorbent polymer (SAP) in the hydrating cement paste of autogenous cured self-compacting concrete (GP-ACSSC) mixtures. In the first hours following casting, water sorptivity, water retention, and hydration tests were carried out. The effects of various concentrations of SAP and GP, which was utilized as an alternative cement for the production of sustainable concrete that leads to reduction in carbon footprint, on the autogenous cured self-compacting concrete with reference to the abovementioned properties were explored. The investigation showed that releasing the curing water at a young age, even around the beginning of hydration, allowed homogenous and almost immediate distribution of water across the full cured paste volume, which improved the water retention kinetics. Compared to the control mixtures, the addition of SAP up to 0.6% and the substitution of cement with GP up to 15% had favorable impacts on all water kinetics parameters.
Polymer and Hybrid Optical Devices Manipulated by the Thermo-Optic Effect
Authors: Xie Yuqi , Chen Liguo , Li Haojia , Yi Yunji
Published: September 2023

The thermo-optic effect is a crucial driving mechanism for optical devices. The application of the thermo-optic effect in integrated photonics has received extensive investigation, with continuous progress in the performance and fabrication processes of thermo-optic devices. Due to the high thermo-optic coefficient, polymers have become an excellent candidate for the preparation of high-performance thermo-optic devices. Firstly, this review briefly introduces the principle of the thermo-optic effect and the materials commonly used. In the third section, a brief introduction to the waveguide structure of thermo-optic devices is provided. In addition, three kinds of thermo-optic devices based on polymers, including an optical switch, a variable optical attenuator, and a temperature sensor, are reviewed. In the fourth section, the typical fabrication processes for waveguide devices based on polymers are introduced. Finally, thermo-optic devices play important roles in various applications. Nevertheless, the large-scale integrated applications of polymer-based thermo-optic devices are still worth investigating. Therefore, we propose a future direction for the development of polymers.
Fused-Deposition Modeling 3D Printing of Short-Cut Carbon-Fiber-Reinforced PA6 Composites for Strengthening, Toughening, and Light Weighting
Authors: Sun Bin , Mubarak Suhail , Zhang Guocun , Peng Kangming , Hu Xueling , Zhang Qia , Wu Lixin , Wang Jianlei
Published: September 2023

Additive manufacturing of carbon-fiber-reinforced polymer (CFRP) has been widely used in many fields. However, issues such as inconsistent fiber orientation distribution and void formation during the layer stacking process have hindered the further optimization of the composite material’s performance. This study aimed to address these challenges by conducting a comprehensive investigation into the influence of carbon fiber content and printing parameters on the micro-morphology, thermal properties, and mechanical properties of PA6-CF composites. Additionally, a heat treatment process was proposed to enhance the interlayer bonding and tensile properties of the printed composites in the printing direction. The experimental results demonstrate that the PA6-CF25 composite achieved the highest tensile strength of 163 MPa under optimal heat treatment conditions: 120 °C for 7.5 h. This corresponds to a significant tensile strength enhancement of 406% compared to the unreinforced composites, which represents the highest reported improvement in the current field of CFRP-fused deposition 3D printing. Additionally, we have innovatively developed a single-layer monofilament CF-OD model to quantitatively analyze the influence of fiber orientation distribution on the properties of the composite material. Under specific heat treatment conditions, the sample exhibits an average orientation angle μ of 0.43 and an orientation angle variance of 8.02. The peak frequency of fiber orientation closely aligns with 0°, which corresponds to the printing direction. Finally, the study explored the lightweight applications of the composite material, showcasing the impressive specific energy absorption (SEA) value of 17,800 J/kg when implementing 3D-printed PA6-CF composites as fillers in automobile crash boxes.
Mechanical Properties, Radiation Resistance Performances, and Mechanism Insights of Nitrile Butadiene Rubber Irradiated with High-Dose Gamma Rays
Authors: Luo Rongrong , Kang Daoan , Huang Chao , Yan Tengfei , Li Pengyuan , Ren Hongxi , Zhang Zhiyuan
Published: September 2023

The radiation effect of materials is very important and directly related to the safety and reliability of nuclear reactors. Polymer materials, one of the indispensable materials in nuclear power equipment, must withstand the ordeal of high-energy ionizing rays. In this work, through screening different γ-ray dose irradiation conditions, we systematically and comprehensively study the changes in the structure and properties of nitrile butadiene rubber (NBR) before and after γ-ray static irradiation at a high dose rate, and master the rule and mechanism of the γ-ray static irradiation effect of these polymer materials. The mapping relationship between the macroscopic properties, microstructure, and irradiation dose of NBR is accurately characterized. With an increase in total irradiation dose, the C=C double bond reaction occurs, and the C≡N bond, C=C, and C=O participate in the hyper crosslinking reaction. The glass transition temperature (Tg) increases with the cumulative irradiation amount. With the increased total irradiation amount, the degree of rubber cross-linking increases, causing an increased crystallinity and decomposition temperature. A growing amount of gamma irradiation causes the mechanical properties of the rubber to degrade simultaneously, increasing the shore hardness while decreasing the tensile strength and ultimate elongation at break. When the cumulative amount reaches 1 MGy, the ultimate elongation at break decreases significantly. A cumulative dose of radiation resistance of 4 MGy can be achieved by the samples. This work can provide theoretical and experimental support for the long-term stability of nitrile butadiene rubber and its derivatives in nuclear radiation fields and space radiation conditions.
Aqueous Cationic Fluorinated Polyurethane for Application in Novel UV-Curable Cathodic Electrodeposition Coatings
Authors: Chen Junhua , Zeng Zhihao , Liu Can , Wang Xuan , Li Shiting , Ye Feihua , Li Chunsheng , Guan Xiaoxiao
Published: September 2023

Aqueous polyurethane is an environmentally friendly, low-cost, high-performance resin with good abrasion resistance and strong adhesion. Cationic aqueous polyurethane is limited in cathodic electrophoretic coatings due to its complicated preparation process and its poor stability and single performance after emulsification and dispersion. The introduction of perfluoropolyether alcohol (PFPE-OH) and light curing technology can effectively improve the stability of aqueous polyurethane emulsions, and thus enhance the functionality of coating films. In this paper, a new UV-curable fluorinated polyurethane-based cathodic electrophoretic coating was prepared using cationic polyurethane as a precursor, introducing PFPE-OH capping, and grafting hydroxyethyl methacrylate (HEMA). The results showed that the presence of perfluoropolyether alcohol in the structure affected the variation of the moisture content of the paint film after flash evaporation. Based on the emulsion particle size and morphology tests, it can be assumed that the fluorinated cationic polyurethane emulsion is a core–shell structure with hydrophobic ends encapsulated in the polymer and hydrophilic ends on the outer surface. After abrasion testing and baking, the fluorine atoms of the coating were found to increase from 8.89% to 27.34%. The static contact angle of the coating to water was 104.6 ± 3°, and the water droplets rolled off without traces, indicating that the coating is hydrophobic. The coating has excellent thermal stability and tensile properties. The coating also passed the tests of impact resistance, flexibility, adhesion, and resistance to chemical corrosion in extreme environments. This study provides a new idea for the construction of a new and efficient cathodic electrophoretic coating system, and also provides more areas for the promotion of cationic polyurethane to practical applications.
Embedded Living HER2+ Cells in a 3D Gelatin–Alginate Hydrogel as an In Vitro Model for Immunotherapy Delivery for Breast Cancer
Authors: De Dios-Figueroa G. Tonantzin , Aguilera-Márquez Janette del Rocío , García-Uriostegui Lorena , Hernández-Gutiérrez Rodolfo , Camacho-Villegas Tanya A. , Lugo-Fabres Pavel H.
Published: September 2023

Epidermal growth factor receptor 2 (HER2) is the second target molecule most commonly used in breast cancer treatment. Both recurrence and metastasis are still deadly for HER2+ breast cancer patients. Hydrogels can be an option for developing three-dimensional (3D) cell culture systems that resemble tumor features better than monolayer cultures and could be used for preclinical screening for new biotherapeutics. Biopolymers (gelatin and alginate) were used to develop a hydrogel capable of encapsulating living HER2+ breast cancer cells BT-474/GFP. The hydrogel was physicochemically characterized, and the viability of embedded cells was evaluated. The hydrogel developed had suitable physical properties, with swelling of 38% of its original mass at 20 h capacity and pore sizes between 20 and 125 µm that allowed cells to maintain their morphology in a 3D environment, in addition to being biocompatible and preserving 90% of cell viability at 10 days. Furthermore, encapsulated BT-474/GFP cells maintained HER2 expression that could be detected by the Trastuzumab-fluorescent antibody, so this hydrogel could be used to evaluate new HER2-targeted therapies.
Advancements in Performance Optimization of Electrospun Polyethylene Oxide-Based Solid-State Electrolytes for Lithium-Ion Batteries
Authors: Li Xiuhong , Deng Yichen , Li Kai , Yang Zhiyong , Hu Xinyu , Liu Yong , Zhang Zheng
Published: September 2023

Polyethylene oxide (PEO)-based solid-state electrolytes for lithium-ion batteries have garnered significant interest due to their enhanced potential window, high energy density, and improved safety features. However, the issues such as low ionic conductivity at ambient temperature, substantial ionic conductivity fluctuations with temperature changes, and inadequate electrolyte interfacial compatibility hinder their widespread applications. Electrospinning is a popular approach for fabricating solid-state electrolytes owing to its superior advantages of adjustable component constitution and the unique internal fiber structure of the resultant electrolytes. Thus, this technique has been extensively adopted in related studies. This review provides an overview of recent advancements in optimizing the performance of PEO solid-state electrolytes via electrospinning technology. Initially, the impacts of different lithium salts and their concentrations on the performance of electrospun PEO-based solid-state electrolytes were compared. Subsequently, research pertaining to the effects of various additives on these electrolytes was reviewed. Furthermore, investigations concerning the enhancement of electrospun solid-state electrolytes via modifications of PEO molecular chains are herein detailed, and lastly, the prevalent challenges and future directions of PEO-based solid-state electrolytes for lithium-ion batteries are summarized.
Microstructure and Tensile Properties of Melt-Spun Filaments of Polybutene-1 and Butene-1/Ethylene Copolymer
Authors: Li Jianrong , Qiao Yongna , Zhang Hao , Zheng Yifei , Tang Zheng , Zeng Zhenye , Yao Pingping , Bao Feng , Liu Huichao , Yu Jiali , Zhu Caizhen , Xu Jian
Published: September 2023

Polybutene-1 with form I crystals exhibits excellent creep resistance and environmental stress crack resistance. The filaments of polybutene-1 and its random copolymer with 4 mol% ethylene co-units were produced via extrusion melt spinning, which are expected to be in form I states and show outstanding mechanical properties. The variances in microstructure, crystallization–melting behavior, and mechanical properties between homopolymer and copolymer filaments were analyzed using SEM, SAXS/WAXD, DSC, and tensile tests. The crystallization of form II and subsequent phase transition into form I finished after the melt-spinning process in the copolymer sample while small amounts of form II crystals remained in homopolymer filaments. Surprisingly, copolymer filaments exhibited higher tensile strength and Young’s modulus than homopolymer filaments, while the homopolymer films showed better mechanical properties than copolymer films. The high degree of orientation and long fibrous crystals play a critical role in the superior properties of copolymer filaments. The results indicate that the existence of ethylene increases the chain flexibility and benefits the formation of intercrystalline links during spinning, which contributes to an enhancement of mechanical properties. The structure–property correlation of melt-spun PB-1 filaments provides a reference for the development of polymer fibers with excellent creep resistance.
Thermal Reflow Simulation for PMMA Structures with Nonuniform Viscosity Profile
Authors: Sidorov Fedor , Rogozhin Alexander
Published: September 2023

This paper presents a new approach to the simulation of the thermal reflow of e-beam-exposed polymethyl methacrylate (PMMA) taking into account its nonuniform viscosity profile. This approach is based on numerical “soapfilm” modeling of the surface evolution, processed by the free software “Surface Evolver” in area normalization mode. The PMMA viscosity profile is calculated via the simulation of the exposed PMMA number average molecular weight distribution using the Monte-Carlo method and empirical formulas. The relation between the PMMA viscosity and the mobility of PMMA surface vertices was determined via the thermal reflow simulation for uniform PMMA gratings using analytical and numerical approaches in a wide viscosity range. The agreement between reflowed profiles simulated with these two approaches emphasizes the applicability of “soapfilm” modeling in the simulation of polymer thermal reflow. The inverse mobility of PMMA surface vertices appeared to be proportional to the PMMA viscosity with a high precision. The developed approach enables thermal reflow simulations for complex nonuniform structures, which allows the use of predictable reflow as a stage of 3D microfabrication.
Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials
Authors: Chelu Mariana , Musuc Adina Magdalena
Published: September 2023

Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.
Investigation of Natural Weak Interface Properties and Their Impact on Fracture Propagation in Shale Reservoirs
Authors: Chen Qi , Huang Zhiqiang , Ling Xingjie , Xu Pengju , Tu Lanke , Liao Wenjing , Xie Jun , Wang Meng , Chen Yijing , Li Lingli
Published: September 2023

Horizontal well multi-cluster fracturing technology is crucial for the economic development of fractured shale reservoirs. The abundance of natural fractures in shale reservoirs significantly influences the propagation path of hydraulic fractures and determines the formation of complex fracture networks. To investigate the impact of natural weak planes on the geometric parameters of fractures in shale reservoirs, we first conducted tests on the mechanical characteristics of core samples from outcropping shale in the Weiyuan area using the indoor three-point bending method and digital image correlation (DIC) technology, providing data validation for subsequent numerical models. Secondly, considering the interaction between hydraulic and natural weak planes in three-dimensional space, we established a three-dimensional numerical model for horizontal well fracturing to simulate the synchronous competition and expansion of fractures in multi-cluster fracturing. Based on this foundation, we analyzed the influence of formation parameters and engineering parameters on the formation patterns of complex fracture networks. The results indicate that the difference in in situ stress is a significant factor affecting the selection of fracture propagation paths. As the in situ stress difference increases, it becomes more challenging to open natural fractures, leading to a reduced probability of activation of natural weak interfaces. When the cohesive strength of natural fractures is smaller, they are more likely to open and capture hydraulic fractures, thereby increasing shear slip length and fracture network area. Each fracturing stage has an optimal perforation density combination, where a higher density of perforations leads to reduced perforation pressure drop and weaker ability to mitigate inter-cluster stress interference. To achieve a comprehensive and balanced development of multi-clusters, the inter-cluster stress interference can be alleviated by increasing the perforation pressure drop. For dense perforation clusters, higher injection rates and viscosity can be employed to ensure the uniform development of multiple perforation clusters. This study provides new insights into predicting the formation of complex fracture networks in shale reservoirs and offers valuable guidance for optimizing hydraulic fracturing designs.
Amomum subulatum Fruit Extract Mediated Green Synthesis of Silver and Copper Oxide Nanoparticles: Synthesis, Characterization, Antibacterial and Anticancer Activities
Authors: Dhir Sarika , Dutt Rohit , Singh Rahul Pratap , Chauhan Mahima , Virmani Tarun , Kumar Girish , Alhalmi Abdulsalam , Aleissa Mohammed S. , Rudayni Hassan A. , Al-Zahrani Mohammed
Published: September 2023

This research presents a straightforward, effective, and eco-friendly method for the production of silver nanoparticles (AgNPs) and copper oxide nanoparticles (CuONPs) using the dried fruit of Amomum subulatum as a reducing, stabilizing, and capping agent. The formation of AgNPs and CuONPs is supported by the presence of a surface plasmon resonance band (SPR) at 440 nm for AgNPs and 245 nm for CuONPs. Additionally, the identification of specific biomolecules responsible for the synthesis of AgNPs and CuONPs was confirmed through FTIR spectra analysis. The Transmission electron microscope (TEM) images demonstrated that AgNPs and CuONPs had spherical shapes, with mean particle diameters of 20.6 nm and 24.7 nm, respectively. X-ray diffraction and selected area electron diffraction (SAED) analyses provided evidence of the crystalline nature of the synthesized AgNPs and CuONPs. Additionally, the presence of silver and copper elements was observed through energy-dispersive X-ray spectroscopy (EDS) analysis. Furthermore, the antibacterial activity of AgNPs was found to be superior to that of CuONPs against human pathogens such as Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The cytotoxic activity of the biosynthesized nanoparticles (NPs) was evaluated in vitro against human cervical cells (HeLa) and human breast cells (MCF-7). In MCF-7 cells, the IC50 value for AgNPs was estimated to be 39.79 µg/mL, while that of CuONPs was 83.89 µg/mL. In HeLa cells, the IC50 value for AgNPs was 45.5 µg/mL, and for CuONPs, it was 97.07 µg/mL. For the first time, an eco-friendly method for the synthesis of AgNPs and CuONPs from fruit extract of Amomum subulatum has been discussed along with their comparative evaluation study. These results highlight the promising applications of the eco-friendly synthesized AgNPs and CuONPs as effective agents against microbial infections and potential candidates for cancer therapy.