bluuebunny/crossref_metadata_2025 huggingface dataset:
SOME ASPECTS OF LANGUAGE REALIZATION OF TEXTUAL CONCEPTS (based on the material of the new testament leading concepts)
Authors:   The Ukrainian Lingua-Information Fund of NAS of Ukraine, SHEVCHENKO L. L.
Published: February 2023

The article is devoted to the analysis of the leading concepts of the New Testament («Jesus Christ», «faith», «salvation», «sin»), and finding out the means of their forming. The concepts under study appear as multidimensional text formations, complex structural units with large sets of verbalizers, organized by associative and semantic fields. Such conceptual activity of language tools in the creation of conceptual structures is due to the fact that these concepts play an important structural role in revealing the meaning of the text, its important communicative tasks, objectify the main thematic lines, the most important semantic dominants associated with the leading biblical ideas created by the context of the whole. The study of the conceptual fields composition through the clarification of lexicalsemantic and syntactic means of their deployment allows us to reveal the content of the studied concepts, presenting them as multidimensional formations formed by interrelated components that nominate them. Concepts empirically generalize the contexts in which they appear, forming a coherent and structured content space organized by conceptual fields. An important part of the textual concepts study is the analysis of speech phenomena involved in their creation. Language explication of conceptual formations occurs largely at the paradigmatic level, which is a set of identical units, — through the means of synonymy (general, contextual and conditional synonyms) and derivation. Representing objects in a voluminous and diverse way, synonymous and derivational tools develop concepts, giving them a fairly comprehensive description. A significant activity of language tools aimed at creating leading text concepts, at forming the richness and diversity of their interpretive fields, indicates the fact that such concepts are associated with the most communicatively significant text parameters, the study of which opens up opportunities for text interpretation, its essential characteristics identification, leading themes and ideas reproducing.
Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia
Authors: Kayser Sabine , Martínez-Cuadrón David , Rodriguez-Veiga Rebeca , Hänel Mathias , Tormo Mar , Schäfer-Eckart Kerstin , Botella Carmen , Stölzel Friedrich , Del Castillo Teresa Bernal , Keller Ulrich , Rodriguez-Medina Carlos , Held Gerhard , Amigo Maria-Luz , Schliemann Christoph , Colorado Mercedes , Kaufmann Martin , Garcia Manuel Barrios , Krause Stefan W. , Görner Martin , Jost Edgar , Steffen Björn , Zukunft Sven , Platzbecker Uwe , Ho Anthony D. , Baldus Claudia D. , Serve Hubert , Müller-Tidow Carsten , Thiede Christian , Bornhäuser Martin , Montesinos Pau , Röllig Christoph , Schlenk Richard F.
Published: February 2023

We retrospectively studied 97 acute myeloid leukemia patients with trisomy 19 (median age at diagnosis 57 years; range, 17- 83 years) treated between 2001 and 2019 within two multicenter study groups. Trisomy 19 occurred alone in ten (10.5%) patients, with additional abnormalities being present in non-complex karyotypes in eight (8%) patients and in complex karyotypes in 79 (82%) patients. Altogether, karyotypes characterized by trisomies only were present in 27 (28%) patients. Data on response and outcome of intensively treated patients were available for 92 cases. The median follow-up was 6.4 years (95% confidence interval [95% CI]: 2.9-9.0 years). The complete remission (CR) rate after induction therapy was 52% (48 patients); the early death rate was 10% (n=9). Notably, patients with trisomy 19 as the sole abnormality had a CR rate of 89%. Allogeneic hematopoietic stem cell transplantation (allo-HCT) was performed in 34 (35%) patients (CR, n=19; active disease, n=15). Five-year relapse-free and overall survival rates were 26% (95% CI: 16-43%) and 20% (95% CI: 13-31%), respectively. Overall survival rates were significantly higher in patients with trisomy 19 as the sole abnormality or within karyotypes characterized by trisomies only (P=0.05). An Andersen-Gill model including allo-HCT as a time-dependent covariable on overall survival revealed that trisomy 19 as the sole abnormality or within karyotypes characterized by trisomies only was a favorable factor (hazard ratio [HR]=0.47; P=0.021); higher age at diagnosis had an adverse impact (10 years difference; HR=1.29; P=0.002), whereas allo-HCT did not have a beneficial impact (odds ratio=1.45; P=0.21). In our cohort, patients with trisomy 19 as the sole abnormality or within karyotypes characterized by trisomies only had a high CR rate and better clinical outcome.
Desain latihan teknik dasar passing dan kontrol pada sepakbola
Authors: Budiono Budiono , Imawati Veni , Rofiâ€™ah Siti , Makrifah Istina Atul
Published: February 2023

Dalam pelaksanaan penelitian ini bertujuan untuk mengembangkan teknik dasar passing dan controlling bagi pemain di team Rea Reo Fc Kota Blitar. Penelitian ini di latar belakangi dari hasil observasi sekaligus wawancara yang di lakukan oleh peneliti pada pelatih dan pemain di team Rea Reo Fc Kota Blitar. Peneliti menemukan bahwa terdapat permasalahan yang terjadi yaitu kurang efektifnya Teknik Dasar Â Passing dan Controlling pada antar individu di team ini, hal itu disebabkan karena pelatih hanya menggunakan teknik dasar yang sama seperti yang dahulu, sehingga terkesan monoton daan itu â€“ itu saja. Mengakibatkan pemain menjadi kurang bersemangat dengan desain yang lama ini. Pelaksanaan penelitian dengan model penelitian Borg and Gall. Adapun instrumen yang digunakan peneliti untuk mengumpulkan data berikut : (1) Angket Validasi Instrumen, (2) Angket Validasi Ahli Sepakbola, (3) Angket Respon Pemain . Tujuan penelitian ini untuk meningkatkan kemampuan individu pemain dalam Teknik DasarPassing dan Controlling. Hasil penelitian ini menunjukan bahwa hasilpenilaian dari ahli Validitas Instrumen mendapatkan skor 80%, Ahli Sepakbola mendapatkan skor (1) 94%, (2) 90%, Angket respon pemain setelah penerapan 90%. Bedasarkan hasil observasi pelatih dan pemainÂ  saat penerapan desain latihan , juga menunjukan adanya kegiatan timbal balik yang baik antara pemain dan pelatih.Â Desain Latihan Teknik Dasar Passing dan Kontrol pada SepakbolaÂ Abstract: In the implementation of this research,the aim is todevelop basic passing and controlling techniques in the Rea Rea Fc team in Blitar City. This research is based on the results of observations as well as interviews conducted by researchers on coaches and players in the Rea Reo Fc team in Blitar City. The researcher found that there were problems that occurred, namely the ineffectiveness of the Basic Passing and Controlling Techniques between individuals in this team, this was because the trainer only used the same basic techniques as before, so it seemed monotonous and that's all. Resulted in players becoming less excited with this old design. The implementation of the research using the Borg and Gall research model. The instruments used by researchers to collect the following data: (1) Instrument Validation Questionnaire, (2) Football Expert Validation Questionnaire, (3) Player Response Questionnaire. The purpose of this study is to improve the individual skills of players in Basic Passing and Controlling Techniques. The results of this study indicate that the results of the assessment of Instrument Validity experts get a score of 80%, Football Experts get a score of (1) 94%, (2) 90%, Questionnaire player responses after the application of 90%. Based on the results of observations of coaches and players when implementing the exercise design, it also shows that there is a good reciprocal activity between players and coaches.
Tuntutan fisik dan karakteristik kinerja pemain sepakbola berdasarkan posisi bermain
Authors: Sumarno Sumarno , Ristiawan Bayu
Published: February 2023

Sepakbola sebagai olahraga tim sekaligus permainan yang kompleks membutuhkan kemampuan taktis, teknis, dan fisik tingkat tinggi untuk berhasil. Selama pertandingan kompetitif, kombinasi acak dari aktivitas eksplosif dan kuat, bersama dengan gerakan teknis dan taktis, dilakukan secara berselang selama 90 menit. Tujuan dari penulisan ini untuk mendiskusikan tuntutan fisik dan karakteristik dari permainan sepakbola.Â Penulisan artikel ini menggunakan teknik review literatur yang berfokus pada tuntutan fisik dan karakteristik kinerja pemain sepakbola yang secara khusus menyajikan perbedaannya pada masing-masing posisi bermain pada sepakbola tingkat elit. Hasil dari pembahasan ini adalah permainan sepakbola didominasi oleh sistem energi anaerobik yang mencirikan aktivitas intermiten dengan intensitas tinggi. Pada peran pada masing-masing posisi, secara spesifik pemain memiliki tuntutan fisik yang berbeda. Kami menyimpulkan bahwa untuk melakukan analisis performa pemain sepakbola harus memperhatikan masing-masing posisi bermain.Â Physical demands and performance characteristics of football players according to playing positionÂ Abstract: Football, as a team sport as well as a complicated game, requires high levels of tactical, technical, and physical skills to achieve. During competitive matches, random combinations of explosive and powerful activities and technical and tactical moves are performed intermittently over 90 minutes. The purpose of this paper is to discuss the physical demands and characteristics of the game of football. Writing of this article uses a literature review technique that focuses on the physical demands and performance characteristics of football players, which specifically presents the differences in each playing position in elite-level football. The result of this discussion is that football is dominated by an anaerobic energy system that characterizes intermittent activity with high intensity. In the role of each position, players have different physical demands. We conclude that in order to analyze football players' performance, they need to pay attention to each playing position.
Ukrainian Children's Periodicals of the 20s – early 40s of the XX century in the fund of the V. Sukhomlynskyi State Scientific and Pedagogical Library of Ukraine
Authors: Tarnavska Snizhana , Hopta Svitlana , Yakobchuk Nadiia , Vasylenko Svitlana
Published: February 2023

The catalog includes information about Ukrainian children's periodicals of the 1920s – early 1940s of the 20th century, which are stored in the fund of the V. Sukhomlynskyi SSPL of Ukraine. The proposed publication reveals the content of children's magazines that were published in Ukraine during the research period, in particular "Bilshovichenyata", "Be Ready!", "Cheerful Brigade", "Young Octobrist", "Children's Movement", "Pioneria", "Red Flowers" etc. The catalog is addressed to scientific and scientific-pedagogical, pedagogic, library workers and all those interested in the history of education and upbringing, pedagogical science, children's literature.
Организационные аспекты поддержки принятия решений в интересах гражданской обороны
Authors: Бордак Сергей Сергеевич
Published: February 2023

Цель. Провести анализ различных типов организационных структур органов управления в интересах поддержки принятия управленческих решений гражданской обороны.
Методы. В качестве теоретической базы использовались методы теории организации и общенаучные методы (индукции, дедукции, анализа и синтеза).
Результаты. Проведен анализ практики подготовки решений начальника гражданской обороны, выявлены наиболее существенные компоненты структуры органов управления гражданской обороны. Предложены различные типы организационных структур с учетом специфики задач, решаемых должностными лицами органов управления.
Область применения исследований. Результаты работы могут быть использованы в научных исследованиях, связанных с аспектами подготовки и ведения гражданской обороны, поддержки принятия решений, а также в практической деятельности начальников и штабов гражданской обороны.
Effect of moisture, temperature, and maternal influence on the hatching, phenotype, and performance of hawksbill turtles Eretmochelys imbricata
Authors: Flores-Aguirre CD , Díaz-Hernández V , Arenas Moreno D , Méndez delaCruz FR
Published: February 2023

Hawksbill turtles are considered Critically Endangered. An understanding of how nest microenvironment (moisture and temperature) and maternal characteristics can influence embryonic development, hatching success, phenotype, and hatchling performance is needed to ensure effective conservation management. We undertook controlled egg incubations at different temperatures and relative humidities. Additionally, we sampled temperatures at natural nests with data loggers, and relative humidity of the sand at nest depth, to determine the conditions that eggs experienced naturally. We varied relative sand humidity (RSH) percentages (30, 50, 75, and 100%) at a constant incubation temperature of 29.5°C. We also assessed constant temperature incubations at 25, 29.5, and 34°C with 75% RSH. Incubation at 29.5°C resulted in successful hatching (73.3%), whereas temperatures of 25 and 34°C prevented hatching. However, hatching in natural nests occurred even between 34 and 36°C, provided that eggs were exposed to these temperatures <20% of the entire period of incubation, and only towards the end of incubation. Controlled incubation at 30% RSH prevented hatching. RSH linearly affected hatching success, phenotype, and performance of hatchlings: eggs incubated at 100% RSH had the greatest hatching success and produced the heaviest, largest, and fastest hatchlings. RSH correlated positively with sand depth on the beach, so that ≥75% RSH is ensured at the average depth of natural nests (~39.2 cm), resulting in successful hatching (74.3 ± 34.7%). The controlled incubation showed that temperature and hydric conditions had the most significant impact on hatching success, hatchling phenotype (size and weight), and hatchling performance. Maternal characteristics, however, were slightly less important. These results suggest that the impact of moisture should be taken into consideration in hawksbill turtle conservation projects. The thermal and hydric environments experienced by developing embryos should also be considered when evaluating how climate change affects marine turtles.
Protocol for the Conconi Test and Determination of the Heart Rate Deflection Point
Authors: Grazzi G , Casoni I , Mazzoni G , Uliari S , Conconi F
Published: February 2023

Recently Ozcelik and Kelestimur (2004) have assessed the validity of the heart rate deflection point in the power output-heart rate relationship (Conconi test) for estimating the anaerobic threshold in different experimental conditions (normoxia and hypoxia). In their study, the tests were performed with an electromagnetically braked cycle ergometer at constant cadence with increments in power output obtained by increasing the pedalling resistance.
Contributions of the Future Eurocode for the Assessment of Existing Concrete Structures
Authors: Díaz-Pavón Eduardo , Rodríguez Raúl , Ley Jorge , López Pedro
Published: February 2023

This article highlights the most relevant aspects of the new generation of Eurocodes for the assessment of existing structures, and in particular those governing concrete structures. In this respect, Eurocode 0 will include a new section (prEN 1990-2. Basis of assessment and retrofitting of existing structures: general rules and actions) covering the approach and analysis that must be included in this type of assessment, while Eurocode 2 (prEN1992-1-1:2021 Design of concrete structures) includes Annex I: Assessment of existing structures, which is informative and covers particular aspects of the assessment of concrete structures.
The Origins and Some Highlights on the New Proposal for Eurocode 2
Authors: Arrieta José María , Rodríguez Jesús , Ganz Hans
Published: February 2023

This paper presents a summary of the procedures for elaborating the Eurocodes that started in the last two decades of the 20th century with some emphasis in the Eurocode 2 on concrete structures. Besides, a general scope of the technical content of new proposal for Eurocode 2 is commented and the main changes are highlighted.
Correlation Between Neutrophil-Lymphocyte Ratio, Platelets-Lymphocyte Ratio, and High-Resolution CT in Patients with COVID-19
Authors: El Hussini Manal S.H. , El Hussieny Mohamed S. , Heiba Ahmed , Elsayed Enass Sayed M. , Hassan Nayera E. , El-Masry Sahar A.
Published: February 2023

Background: COVID-19 is a highly infectious disease that necessitates simple and rapid methods for recognising severe patients.

Aims: To correlate between chest lesions in CT, neutrophil-lymphocyte ratio (NLR), and platelets-lymphocytes ratio in patients with COVID-19, and to detect their cut-off values as an early warning of severe COVID-19 in Egyptian patients.

Subjects and Methods: A cross-sectional study included 100 adult patients with COVID-19 attending Ahmed Maher Teaching Hospital, Cairo, Egypt. Clinical, laboratory, and radiological assessments were done. They were classified according to their CT grades into three groups: seven patients with a normal chest CT, 45 non-severe cases, and 48 severe cases.

Results: Dyspnoea was the most common symptom among the severe cases (79.2%) and fever among non-severe cases (71.1%), while cough (85.7%) was the most common among cases with a normal CT. The age, NLR, C-reactive protein (CRP), and D-dimer of severe cases were significantly the highest, while the absolute lymphocytes were significantly the lowest. Highly significant positive correlations were found between CT grades with D-dimer, NLR, and CRP; significant positive correlation was found with age; and significant negative correlation with CT. Using receiver operating characteristic analysis, areas under the curve of D-dimer, NLR, age, CRP, ferritin, and platelet-lymphocyte ratio were 0.760, 0.698, 0.640, 0.627, 0.614, and 0.595, respectively. The optimal cut-off value of NLR was 2.50 with 0.74 specificity, 0.61 sensitivity, and 67.5 accuracy.

Conclusion: NLR is a reliable and easy-to-use predictor of COVID-19 severity. NLR (>2.5) should prompt prescription of a chest CT as it could reveal essential lesions that influence further management.
A pitvarfibrilláció diagnosztikájának, antikoaguláns-kezelésének és a betegadherencia fenntartásának modern gyakorlata
Authors: Lukács Réka Alíz , Tornyos Dániel , Tóth Judit , Komócsi András
Published: February 2023

A pitvarfibrilláció (PF) a leggyakoribb tartós szívritmuszavar, azonban az esetek egyharmadában a beteg tünetmentes marad. A nem diagnosztizált és alulkezelt pitvarfibrilláció hozzájárul az ischaemiás stroke kialakulásához, ezért a PF szűrése magában hordozza a korai ritmuskezelés, a stroke és a halálozás megelőzésének lehetőségét. Ennek kapcsán az utóbbi évtizedben jelentős előrelépések tanúi voltunk a mindennapi használatban lévő digitális eszközök fejlődése terén. Ezek új lehetőségeket nyújthatnak a szívritmuszavar időben történő felismerésében. A korai diagnosztikát és az ideális gyógyszeres kezelés beállítását követően a megfelelő terápia elengedhetetlen része a betegadherencia fenntartása. A páciens bevonása a döntési folyamatba és az antikoaguláció lehetőségeinek vele való megbeszélése („közös döntéshozatal”) kulcsfontosságú a beteg szükségleteinek megfelelő felméréséhez és az adherencia növeléséhez. Cikkünk célja, hogy naprakész gyakorlati útmutatást nyújtson a digitális eszközök szívritmuszavar esetén tör­ténő megfelelő alkalmazásához, valamint összefoglaló áttekintést adjon a minden­napi gyakorlatban használt antikoagulánsokkal kapcsolatos adherencia növelésének kihívásairól.
Az életmódváltás és a testsúlykontroll szerepe a terhességi cukorbetegség primer és szekunder prevenciójában
Authors: Sági Veronika
Published: February 2023

A terhességi cukorbetegség az egyik leggyakoribb terhességi szövődmény, napjainkban is intenzív kutatás tárgya. Az állapot kezelése és utánkövetése az elmúlt évtizedekben nagy hangsúlyt kapott. Mindezek ellenére viszonylag kevés információ áll rendelkezésre a terhességi cukorbetegség és az ennek talaján később kialakuló 2-es típusú cukorbetegség megelőzésének lehetőségeiről. A jelen összefoglaló friss szakirodalmi adatokra támaszkodva próbál rávilágítani arra, hogy a kedvezőtlen életmódbeli tényezők nagyobb szerepet játszanak a betegség kialakulásában, mint a genetikai hajlam. Az ideális testsúly elérése és fenntartása, a szervezet inzulinérzékenységének alacsony glykaemiás indexű diétával és aerob mozgással történő javítása az egészség megőrzésének a kulcsa terhességi cukorbetegségen átesett nők esetében.
Hogyan lettek a sebészekből orvosok?
Authors: Balázs Péter
Published: February 2023

Ma természetesnek tekintjük, hogy a sebészek is az orvosi hivatásrend tagjai, de az 1700-as évek végéig valamennyien céhes mesteremberként dolgoztak. Az orvoslásnak az őskortól kezdve létezett egy szellemi (spirituális) és manuális vonulata. Az előbbi a vallási kultuszokhoz társult, és a „rejtett belső” betegségekkel foglalkozott. Hippokratész természettudományos iskolája nyitotta meg az utat az utóbbi betegségek kezeléséhez, és a manuális orvoslást is sajátjának tekintette. A kereszténységnek nincs és nem is volt vallási gyógykultusza, így a keresztény világi orvosok a kezdetektől a hippokratészi medicinát művelték. Sőt, ez az orvoslás az egyház belső szervezetében is berendezkedett, és az 1200-as évek elejére olyan üzleteléssé fajult, hogy teológiai és szolgálati szempontból is cselekvési kényszerhelyzetet teremtett. Az egyháziak eltiltása nyitotta meg az utat a világi orvosképzés előtt, de az egyetemek elzárkóztak az alacsonyabb rendűnek tartott manuális orvoslás elől. A sebészetből így céhes mesteremberi tevékenység lett. Egyes tehetséges mesteremberek azonban az 1700-as években egyetemi orvosi diplomát is szereztek. Végül a magas szintű katonai sebészet iránti igény tette rendszeressé a sebész doktori diploma bevezetését. A durva kétkezi stílustól való megszabadulás 1846-ban az éternarkózissal kezdődött. Semmelweis Ignác már 1847-ben igazolta, hogy mennyire jelentős a manuális orvos kezének fertőtlenítése. Joseph Lister karbolsavas antiszeptikus eljárása tette lehetővé 1867-től, hogy az eleve fertőzött sebek gyorsabban gyógyuljanak. Ezt követte a műtőkben az aszepszis és a fehér színvilág bevezetése. A sebészek doktor­rá válásának utolsó előtti mozzanata az Amerikai Egyesült Államokban Baltimore-hoz kötődik, a gumikesztyű bevezetésével. Végül is a szakma szó szerint tiszta kézzel, bűzös szagoktól mentesen, talpig fehérben, az orvoslás győzteseként lépett át a 20. századba, és tovább folytatta diadalútját.
Prediksi Penjualan Spare Part Mobil Daihatsu Menggunakan Algoritma Apriori
Authors: Ramadhan Mukhlis , Hutagalung Juniar , Dahria Muhammad , Zulkarnain Iskandar , Jaya Hendra
Published: February 2023

Pada masa pandemic covid 19, Perusahaan yang bergerak di bidang spare part mengalami penurunan penjualan produk sparet part mobil dan tidak tepat dalam menentukan strategi promosi yang diberikan ke pelanggan. Banyaknya data transaksi yang digunakan sebagi acuan menjual produk dengan harga modal yang hanya mendapatkan keuntungan kecil. Apabila masih tidak laku terjual, untuk barang masuk tertunda dikarenakan modal belum balik. Oleh karena itu diperlukan suatu sistem untuk mengolah data informasi lebih cepat dan tepat dalam melakukan prediksi pola penjualan spare part mobil dengan menggunakan aplikasi data mining algoritma apriori. Hasil perhitungan dengan menerapkan algoritma apriori menunjukkan bahwa jika konsumen membeli lower arm daihatsu dan ban mobil maka nilai support = 23,33 dan nilai confidence = 77,78 dan jika konsumen membeli lower arm daihatsu dan filter AC maka nilai support = 26,67 dan nilai confidence = 72,72. Tujuan penelitian untuk memprediksi dan menganalisa pola penjualan spare part mobil yang diimplementasikan pada aplikasi berbasis desktop. Hal ini untuk mempermudah dalam melakukan analisa terhadap daya saing produk spare part mobil yang paling laku terjual secara bersamaan. Sebagai rekomendasi dalam pengambil keputusan untuk meningkatkan pemasaran dan promosi produk spare part mobil yang lebih baik.
China Pakistan Economic Corridor: Its Prospects and Implications for Gwadar and Balochistan
Authors: Chohan Dildar Ali , Chandio Amir Ali
Published: February 2023

The China-Pakistan Economic Corridor is a multibillion-dollar project of direct investment in a corridor of energy and infrastructure. Besides, there are good potential prospects like the construction of port and road facilities, airports, and energy corridors. It has implications for Balochistan and Gwadar. Although previous studies have highlighted the problems of Balochistan, this paper presents a theoretical framework with reference to the economic corridor. The study has a hypothesis: Baloch people have some reservations about multi-purpose projects. It has impacted the geographic and demographic profile of Balochistan. Other projects are waiting for consideration, such as those related to the water shortage, technical and vocational centers, and employment opportunities. The purpose of this study is to examine the implications and prospects. Every project should aim to facilitate the local masses. The government should shrink dependency and focus on imports, trade imbalances, and foreign loans to resurface its image for elections. It has been discovered that CPEC will cause social change and stratification, as well as Communist influence on minds and effects on aquatic life at Gwadar Harbor. The study suggests: 7% of Gwadar Port Authority revenue for Gwadar and Balochistan; job quotas; parity; public-private partnerships; etc. Finally, it concludes that Gwadar and Balochistan are not reaping immense benefits from this billionaire project. Under the 18th Amendment, Gwadar should be subject to the Balochistan government, the province should be autonomous, etc. Data was gathered through secondary sources such as printed and electronic media. Besides, theoretical, and conceptual frameworks are present in the paper. This is a qualitative study with deductive reasoning to analyze and interpret the collected data.
Pakistan and Central Asian Relations in the Context of Global Politics
Authors: Akbar Nabeila , Khan Haseeb Qasim
Published: February 2023

Central Asia and South-West Asia have become more important in world politics in recent years, especially when the Soviet Union invaded Afghanistan and after it left at the start of the US-Afghan war. In other words, the closing of the twentieth century and the beginning of the twenty-first century have developed multifaceted political environments in the region, which have involved Pakistan as well. Central Asia is the second largest energy reservoir of oil, gas, and hydrocarbons after the Persian Gulf and is the core region of the Asian continent, whereas Pakistan is located at the convergence of South Asia, Central Asia, and West Asia and provides the shortest access to warm water seas for all landlocked Central Asian states. Pakistan also acts as a junction of multiple corridors of economic cooperation between these three regions in the fields of energy, trade, transportation, and tourism. Pakistan will become an economic centre and spur interregional economic activity as a result of the communication and commercial links that connect South Asia, Central Asia, and West Asia. Most of the research available on Central Asia and Pakistan is focused either on the Great Game and internal instability of Central Asian states or on the historical linkage and cultural association of Pakistan with Central Asia, with a superficial discussion on regional trade between them. No research has been done on the geopolitical and economic position of Pakistan in Central Asia, and the instability in Afghanistan is also affecting the associations between Pakistan and Central Asian States. In this research paper, the emphasis has been laid on why geostrategic and economic relations between Pakistan and Central Asian states are significant. Certain other questions have also been answered, like: what is the geopolitical significance of Pakistan and the CARs in world politics? What are the divergent interests of local and international powers in Central Asia? And how has the conflict of interests among these actors hampered the economic development of Pakistan and the CARs? Descriptive and analytical research methodologies are used to probe into the phenomenon of global politics.
Food Security and Vivacious Circle of Poverty Among Rural Households in Pakistan
Authors: Nawaz Rabbia , Iftikhar Muhammad , Khan Ghazanfar A. , Akhtar Saira
Published: February 2023

Food security and poverty are interrelated as well as important factors for determining the household’s development. We conducted this study in District Muzaffargarh of Punjab Province to analyze the food security and poverty nexus. District Muzaffargarh was selected purposively as a study area because it is food insecure and the poorest district in the Punjab province. The sample was selected using a multistage random sampling technique. A total of 349 respondents were selected from 8 villages. This study was quantitative. Data were analyzed using descriptive statistics, correlation, cost of calorie method, FGT poverty index and logit regression. Results indicated that agriculture was a profound source of income and a heft dependency of families was seen attached to agriculture. This can be deduced that food security in the study area was directly associated with agricultural growth. The majority of the respondents in the study area were food insecure, especially in terms of food accessibility and utilization. The majority of constituents of the sample were poor as their expenditures were found to exceed their earnings. As result, the families were trapped in the vivacious circle of poverty. Households had no proper coping strategies or safety nets to confront poverty and achieve food security. This study established that food insecurity was mainly caused by persisting poverty. Thus, eliminating poverty among households through governmental efforts, subsidies, technical support, training, skill development opportunities and microfinance loaning to initiate micro-level businesses.
PREDIKSI AWAL MUSIM HUJAN DI WAINGAPU PROVINSI NUSA TENGGARA TIMUR MENGGUNAKAN METODE ARIMA
Authors: Eka Putra Rama Dani , Sinardi Amarta
Published: February 2023

The beginning of the rainy season can be predicted by various methods such as the Autoregressive Integrated Moving Average (ARIMA). Occurrence of the onset of the rainy season (AMH), the erratic impact on various sectors, especially in the agricultural sector often results in crop failure. Therefore, the aim of this study is to improve the accuracy of predictions for the start of the rainy season. In this study daily rainfall data, the beginning of the rainy season data is obtained by calculating daily rainfall data using the Liebmann method. The best ARIMA model (3,1,0) with the equation y = 0,3162−1 + 0,1284−2−0,188−3 + 0,7434−4−0,934 is used for July, August and DMI data in August are considered as input and prediction error value ARIMA as a target. The beginning of the rainy season prediction results based on ARIMA, the results of testing and evaluation obtained values ​​of r = 0.14 and RMSE = 32.53.
Analisis Jaringan Intranet Di Universitas Flores Menggunakan Quality Of Service (QoS)
Authors: Witi Ferdinandus Lidang , Mude Anastasia
Published: February 2023

Universitas Flores memanfaatkan fasilitas intranet untuk melaksanakan seluruh kegiatan baik dibidang pendidikan dan pengajaran, kegiatan administrasi akademik dan kemahasiswaan, maupun disemua bidang yang mendukung terlaksananya kegiatan  tridarma perguruan tinggi. Jaringan intranet yang ada di Universitas Flores mengalami peningkatan dari tahun ke tahun, dan di tahun 2018 Universitas Flores kembali meningkatkan layanan jaringan intranet menggunakan Cloud Router Switch dengan Virtual Local Area Network. Universitas Flores juga menyediakan layanan hotspot dan wifi di beberapa titik strategi untuk memudahkan seluruh kegiatan akademik. Metode yang digunakan metode action research dengan model sistem monitoring QoS. Software untuk menguji parameter QoS adalah Axence Nettools. Hasil pengolahan data ditampilkan dalam bentuk tabel untuk memudahkan user dalam menganalisis. Dari hasil penelitian disimpulkan bahwa kualitas layanan jaringan intranet di gedung rektorat merupakan kualitas layanan intranet terbaik dengan nilai throughput terbesar yaitu 80,006%, nilai Packet Loss 0% dan nilai Jitter 0%.
Algoritma Classifier Untuk Menganalisis Faktor Pemilihan Hunian Tempat Tinggal
Authors: Elisa Erlin
Published: February 2023

Batam City is the largest city in the RIAU archipelago, the population is also included in the island with the largest population when compared to other islands. According to data from the Central Statistics Agency (BPS), Batam City recorded the projected population growth in Batam in 2019 as many as 1,376,009 people. The development of the increasing population will gradually start to cause new problems, namely the problem of housing or housing. When viewed from the incident so far, the factors or reasons for choosing a residential place to live are not understood by the community so that when they buy, problems often occur, such as not matching the price or problems with developers such as difficult mortgage management and an unsuitable environment and many problems. other. This study will analyze the choice of residential housing with the C4.5 datamining technique and rapid mining as data testing tools, the results of this study show that the main factors for housing selection are clean water sanitation, accessibility, accessibility and price after testing the accuracy of C4.5 data. 25 sample data obtained 88.00% accuracy of the performance of this algorithm.
Effects of different preservation on the mechanical properties of cortical bone under quasi-static and dynamic compression
Authors: Qiu Jinlong , Liao Zhikang , Xiang Hongyi , Li Haocheng , Yuan Danfeng , Jiang Chengyue , Xie Jingru , Qin Mingxin , Li Kui , Zhao Hui
Published: February 2023

Introduction: Mechanical properties of biological tissue are important for numerical simulations. Preservative treatments are necessary for disinfection and long-term storage when conducting biomechanical experimentation on materials. However, few studies have been focused on the effect of preservation on the mechanical properties of bone in a wide strain rate. The purpose of this study was to evaluate the influence of formalin and dehydration on the intrinsic mechanical properties of cortical bone from quasi-static to dynamic compression.

Methods: Cube specimens were prepared from pig femur and divided into three groups (fresh, formalin, and dehydration). All samples underwent static and dynamic compression at a strain rate from 10−3 s−1 to 103 s−1. The ultimate stress, ultimate strain, elastic modulus, and strain-rate sensitivity exponent were calculated. A one-way ANOVA test was performed to determine if the preservation method showed significant differences in mechanical properties under at different strain rates. The morphology of the macroscopic and microscopic structure of bones was observed.

Results: The results show that ultimate stress and ultimate strain increased as the strain rate increased, while the elastic modulus decreased. Formalin fixation and dehydration did not affect elastic modulus significantly whereas significantly increased the ultimate strain and ultimate stress. The strain-rate sensitivity exponent was the highest in the fresh group, followed by the formalin group and dehydration group. Different fracture mechanisms were observed on the fractured surface, with fresh and preserved bone tending to fracture along the oblique direction, and dried bone tending to fracture along the axial direction.

Discussion: In conclusion, preservation with both formalin and dehydration showed an influence on mechanical properties. The influence of the preservation method on material properties should be fully considered in developing a numerical simulation model, especially for high strain rate simulation.
Long-term cultures of human pancreatic islets in self-assembling peptides hydrogels
Authors: Marchini Amanda , Ciulla Maria Gessica , Antonioli Barbara , Agnoli Alessandro , Bovio Umberto , Visnoviz Virginia , Bertuzzi Federico , Gelain Fabrizio
Published: February 2023

Human pancreatic islets transplantation is an experimental therapeutic treatment for Type I Diabetes. Limited islets lifespan in culture remains the main drawback, due to the absence of native extracellular matrix as mechanical support after their enzymatic and mechanical isolation procedure. Extending the limited islets lifespan by creating a long-term in vitro culture remains a challenge. In this study, three biomimetic self-assembling peptides were proposed as potential candidates to recreate in vitro a pancreatic extracellular matrix, with the aim to mechanically and biologically support human pancreatic islets, by creating a three-dimensional culture system. The embedded human islets were analyzed for morphology and functionality in long-term cultures (14-and 28-days), by evaluating β-cells content, endocrine component, and extracellular matrix constituents. The three-dimensional support provided by HYDROSAP scaffold, and cultured into MIAMI medium, displayed a preserved islets functionality, a maintained rounded islets morphology and an invariable islets diameter up to 4 weeks, with results analogues to freshly-isolated islets. In vivo efficacy studies of the in vitro 3D cell culture system are ongoing; however, preliminary data suggest that human pancreatic islets pre-cultured for 2 weeks in HYDROSAP hydrogels and transplanted under subrenal capsule may restore normoglycemia in diabetic mice. Therefore, engineered self-assembling peptide scaffolds may provide a useful platform for long-term maintenance and preservation of functional human pancreatic islets in vitro.
Bioactive cellulose acetate nanofiber loaded with annatto support skeletal muscle cell attachment and proliferation
Authors: Santos Ana Elisa Antunes dos , Cotta Tiago , Santos João Paulo Ferreira , Camargos Juliana Sofia Fonseca , Carmo Ana Carolina Correia do , Alcântara Erika Gabriele Alves , Fleck Claudia , Copola Aline Gonçalves Lio , Nogueira Júlia Meireles , Silva Gerluza Aparecida Borges , Andrade Luciana de Oliveira , Ferreira Roberta Viana , Jorge Erika Cristina
Published: February 2023

Electrospinning emerged as a promising technique to produce scaffolds for cultivated meat in function of its simplicity, versatility, cost-effectiveness, and scalability. Cellulose acetate (CA) is a biocompatible and low-cost material that support cell adhesion and proliferation. Here we investigated CA nanofibers, associated or not with a bioactive annatto extract (CA@A), a food-dye, as potential scaffolds for cultivated meat and muscle tissue engineering. The obtained CA nanofibers were evaluated concerning its physicochemical, morphological, mechanical and biological traits. UV-vis spectroscopy and contact angle measurements confirmed the annatto extract incorporation into the CA nanofibers and the surface wettability of both scaffolds, respectively. SEM images revealed that the scaffolds are porous, containing fibers with no specific alignment. Compared with the pure CA nanofibers, CA@A nanofibers showed increased fiber diameter (420 ± 212 nm vs. 284 ± 130 nm). Mechanical properties revealed that the annatto extract induces a reduction of the stiffness of the scaffold. Molecular analyses revealed that while CA scaffold favored C2C12 myoblast differentiation, the annatto-loaded CA scaffold favored a proliferative state of these cells. These results suggest that the combination of cellulose acetate fibers loaded with annatto extract may be an interesting economical alternative for support long-term muscle cells culture with potential application as scaffold for cultivated meat and muscle tissue engineering.
ROS production in response to high-power microwave pulses induces p53 activation and DNA damage in brain cells: Radiosensitivity and biological dosimetry evaluation
Authors: Rana Juie Nahushkumar , Mumtaz Sohail , Choi Eun Ha , Han Ihn
Published: February 2023

Background: Pulsed high-power microwave (HPM) has many applications and is constantly being researched to expand its uses in the future. As the number of applications grows, the biological effects and safety level of pulsed HPM become a serious issue, requiring further research.

Objective: The brain is regarded as the most vulnerable organ to radiation, raising concerns about determining an acceptable level of exposure. The effect of nanosecond pulses and the mechanisms underlying HPM on the brain has not been studied. For the first time, we observed the effect of pulsed 3.5 GHz HPM on brain normal astrocytes and cancer U87 MG cells, as well as the likely mechanisms involved.

Methods: To generate 3.5 GHz HPM, an axial virtual cathode oscillator was constructed on pulsed power generator “Chundoong”. The cells were directly exposed to HPM (10, 25, 40, and 60) pulses (1 mJ/pulse), with each pulse delivered after 1 min of charging time to evaluate the dose dependent effects.

Results: A strong electric field (∼23 kV/cm) of HPM irradiation primarily causes the production of reactive oxygen species (ROS), altering cell viability, mitochondrial activity, and cell death rates in U87 and astrocytes at certain dosages. The ROS generation in response to HPM exposure was primarily responsible for DNA damage and p53 activation. The hazardous dosage of 60 pulses is acknowledged as having damaging effects on brain normal cells. Interestingly, the particular 25 pulses exhibited therapeutic effects on U87 cells via p53, Bax, and Caspase-3 activation.

Conclusion: HPM pulses induced apoptosis-related events such as ROS burst and increased oxidative DNA damage at higher dosages in normal cells and specific 25 pulses in cancer U87. These findings are useful to understand the physiological mechanisms driving HPM-induced cell death, as well as the safety threshold range for HPM exposure on normal cells and therapeutic effects on cancer U87. As HPM technology advances, we believe this study is timely and will benefit humanity and future research.
Science, fiction, and Santa Claus: Hollywood creator and consultant perceptions of fictional science in film and television
Authors: Davis Jessica L. , Savoie Gianna , Longnecker Nancy
Published: February 2023

Introduction

From the high-stakes operating room of a Seattle hospital, to the shattered remains of a planet in a galaxy far, far away, Hollywood is often critiqued for its representations of scientific knowledge, methods, and/or technology. Existing research into Hollywood representations of science focuses primarily on those that do not align with expert consensus, and on how audiences engage with these representations — such as how misinformation in fictional narratives influences us. This paper, instead, approaches the matter of fictional science in fictional narratives (FiSci) from the perspectives of the individuals creating Hollywood content. We use the label of “FiSci” for any representation of science within a narrative which does not align with humanity's current knowledge or technological capability.

Methods

Semi-structured interviews were conducted in late 2020 with a purposefully-selected sample of both Hollywood creators (writers, directors, and producers; n = 28) and science experts who have served as consultants (n = 18) across a range of film and television projects. Thematic analysis was used to explore how these creators and consultants perceive FiSci and its role within Hollywood narratives. Three themes were constructed from the interview data.

Results and discussion

Participants primarily spoke of FiSci as: (1) a storytelling tool, perceived either positively or negatively, depending upon how that tool is wielded; (2) a way to play within a constructed storyworld which does not resemble our own; and (3) a source of unrealistic “B.S.” which threatens to break audience suspension of disbelief and can signify a lack of effort in the creative process. This paper contributes to science communication research by providing access to minds behind the representations of science in Hollywood film and television. As such, it can be used to aid the creator-consultant relationship and the implementation of FiSci to the benefit of both groups. It may also inform creators who have yet to work with a consultant, experts looking to become consultants, audiences critiquing FiSci in the content they watch, and experts and science communicators who express concerns about the use of FiSci and the responsibilities of Hollywood.
Prognostic value of forward flow indices in primary mitral regurgitation due to mitral valve prolapse
Authors: Petolat Elisabeth , Theron Alexis , Resseguier Noemie , Fabre Cyprien , Norscini Giulia , Badaoui Rita , Habib Gilbert , Collart Frederic , Zaffran Stéphane , Porto Alizée , Avierinos Jean-François
Published: February 2023

Background

Degenerative mitral regurgitation (DMR) due to mitral valve prolapse (MVP) is a common valve disease associated with significant morbidity and mortality. Timing for surgery is debated for asymptomatic patients without Class I indication, prompting the search for novel parameters of early left ventricular (LV) systolic dysfunction.

Aims

To evaluate the prognostic impact of preoperative forward flow indices on the occurrence of post-operative LV systolic dysfunction.

Methods

We retrospectively included all consecutive patients with severe DMR due to MVP who underwent mitral valve repair between 2014 and 2019. LVOTTVI, forward stroke volume index, and forward LVEF were assessed as potential risk factors for LVEF <50% at 6 months post-operatively.

Results

A total of 198 patients were included: 154 patients (78%) were asymptomatic, and 46 patients (23%) had hypertension. The mean preoperative LVEF was 69 ± 9%. 35 patients (18%) had LVEF ≤ 60%, and 61 patients (31%) had LVESD ≥40 mm. The mean post-operative LVEF was 59 ± 9%, and 21 patients (11%) had post-operative LVEF<50%. Based on multivariable analysis, LVOTTVI was the strongest independent predictor of post-operative LV dysfunction after adjustment for age, sex, symptoms, LVEF, LV end systolic diameter, atrial fibrillation and left atrial volume index (0.75 [0.62–0.91], p < 0.01). The best sensitivity (81%) and specificity (63%) was obtained with LVOTTVI ≤15 cm based on ROC curve analysis.

Conclusion

LVOTTVI represents an independent marker of myocardial performance impairment in the presence of severe DMR. LVOTTVI could be an earlier marker than traditional echo parameters and aids in the optimization of the timing of surgery.