bluuebunny/crossref_metadata_2025 huggingface dataset:
Thermoreversible Gelation with Two-Component Mixed Cross-Link Junctions of Variable Multiplicity in Ternary Polymer Solutions
Authors: Tanaka Fumihiko
Published: July 2021

Theoretical scheme is developed to study thermoreversible gelation interfering with liquid–liquid phase separation in mixtures of reactive f-functional molecules R{Af} and g-functional ones R{Bg} dissolved in a common solvent. Formed polymer networks are assumed to include multiple cross-link junctions containing arbitrary numbers k1 and k2 of functional groups A and B of each species. Sol-gel transition lines and spinodal lines are drawn on the ternary phase plane for some important models of multiple cross-link junctions with specified microscopic structure. It is shown that, if the cross-link structure satisfies a certain simple condition, there appears a special molar ratio of the two functional groups at which gelation takes place with a lowest concentration of the solute molecules, as has been often observed in the experiments. This optimal gelation concentration depends on f and g (functionality) of the solute molecules and the numbers k1 and k2 (multiplicity) of the functional groups in a cross-link junction. For cross-links which allow variable multiplicity, special attention is paid on the perfectly immiscible cross-links leading to interpenetrating polymer networks, and also on perfectly miscible cross-links leading to reentrant sol-gel-sol transition. Results are compared with recent observations on ion-binding polymer solutions, polymer solutions forming recognizable biomolecular complexes, polymer/surfactant mixtures, hydrogen-bonding polymers, and hydrophobically-modified amphiphilic water-soluble polymers.
Development of an Early Alert System for an Additional Wave of COVID-19 Cases Using a Recurrent Neural Network with Long Short-Term Memory
Authors: Stevenson Finn , Hayasi Kentaro , Bragazzi Nicola Luigi , Kong Jude Dzevela , Asgary Ali , Lieberman Benjamin , Ruan Xifeng , Mathaha Thuso , Dahbi Salah-Eddine , Choma Joshua , Kawonga Mary , Mbada Mduduzi , Tripathi Nidhi , Orbinski James , Mellado Bruce , Wu Jianhong
Published: July 2021

The impact of the still ongoing “Coronavirus Disease 2019” (COVID-19) pandemic has been and is still vast, affecting not only global human health and stretching healthcare facilities, but also profoundly disrupting societal and economic systems worldwide. The nature of the way the virus spreads causes cases to come in further recurring waves. This is due a complex array of biological, societal and environmental factors, including the novel nature of the emerging pathogen. Other parameters explaining the epidemic trend consisting of recurring waves are logistic–organizational challenges in the implementation of the vaccine roll-out, scarcity of doses and human resources, seasonality, meteorological drivers, and community heterogeneity, as well as cycles of strengthening and easing/lifting of the mitigation interventions. Therefore, it is crucial to be able to have an early alert system to identify when another wave of cases is about to occur. The availability of a variety of newly developed indicators allows for the exploration of multi-feature prediction models for case data. Ten indicators were selected as features for our prediction model. The model chosen is a Recurrent Neural Network with Long Short-Term Memory. This paper documents the development of an early alert/detection system that functions by predicting future daily confirmed cases based on a series of features that include mobility and stringency indices, and epidemiological parameters. The model is trained on the intermittent period in between the first and the second wave, in all of the South African provinces.
“If You Don’t See the Dog, What Can You Do?” Using Procedures to Negotiate the Risk of Dog Bites in Occupational Contexts
Authors: Owczarczak-Garstecka Sara C. , Christley Robert M. , Watkins Francine , Yang Huadong , Westgarth Carri
Published: July 2021

Dog bites are a health risk in a number of workplaces such as the delivery, veterinary and dog rescue sectors. This study aimed to explore how workers negotiate the risk of dog bites in daily interactions with dogs and the role of procedures in workplace safety. Participants who encounter dogs at work were recruited using snowball sampling. Ethnographic methods (interviews, focus group discussions, participant-observations) were used for data collection. All data were coded qualitatively into themes. Six themes describing dog bite risk management were identified: ‘Surveillance of dogs’; ‘Communicating risk; ‘Actions taken to manage perceived risk’; ‘Reporting bites and near-misses’, ‘Investigating bites and near-misses’, and; ‘Learning and teaching safety’. While the procedures described dog bite risk as objective, when interacting with dogs, participants drew on experiential knowledge and subjective judgment of risk. There was a discrepancy between risks that the procedures aimed to guard against and the risk participants were experiencing in the course of work. This often led to disregarding procedures. Paradoxically, procedures generated risks to individual wellbeing and sometimes employment, by contributing to blaming employees for bites. Dog bite prevention could be improved by clarifying definitions of bites, involving at risk staff in procedure development, and avoiding blaming the victim for the incident.
Stress and Associated Factors among Frontline Healthcare Workers in the COVID-19 Epicenter of Da Nang City, Vietnam
Authors: Nguyen Nhan Phuc Thanh , Le Duong Dinh , Colebunders Robert , Siewe Fodjo Joseph Nelson , Tran Trung Dinh , Vo Thang Van
Published: July 2021

Frontline healthcare workers (HCWs) involved in the COVID-19 response have a higher risk of experiencing psychosocial distress amidst the pandemic. Between July and September 2020, a second wave of the COVID-19 pandemic appeared in Vietnam with Da Nang city being the epicenter. During the outbreak, HCWs were quarantined within the health facilities in a bid to limit the spread of COVID-19 to their respective communities. Using the stress component of the 21-item Depression, Anxiety and Stress Scale (DASS-21), we assessed the level of stress among HCWs in Da Nang city. Between 30 August and 15 September 2020, 746 frontline HCWs were recruited to fill in an online structured questionnaire. Overall, 44.6% of participants experienced increased stress and 18.9% severe or extremely severe stress. In multivariable analysis, increased stress was associated with longer working hours (OR = 1.012; 95% CI: 1.004–1.019), working in health facilities providing COVID-19 treatment (OR = 1.58, 95% CI: 1.04–2.39), having direct contact with patients or their bio-samples (physicians, nurses and laboratory workers; OR = 1.42, 95% CI: 1.02–1.99), low confidence in the available personal protective equipment (OR = 0.846; 95% CI: 0.744–0.962) and low knowledge on COVID-19 prevention and treatment (OR = 0.853; 95% CI: 0.739–0.986). In conclusion, many frontline HCWs experienced increased stress during the COVID-19 outbreak in Da Nang city. Reducing working time, providing essential personal protective equipment and enhancing the knowledge on COVID-19 will help to reduce this stress. Moreover, extra support is needed for HCWs who are directly exposed to COVID-19 patients.
Trunk Posture during Manual Materials Handling of Beer Kegs
Authors: Brents Colleen , Hischke Molly , Reiser Raoul , Rosecrance John
Published: July 2021

Craft brewing is a rapidly growing industry in the U.S. Most craft breweries are small businesses with few resources for robotic or other mechanical-assisted equipment, requiring work to be performed manually by employees. Craft brewery workers frequently handle stainless steel half-barrel kegs, which weigh between 13.5 kg (29.7 lbs.) empty and 72.8 kg (161.5 lbs.) full. Moving kegs may be associated with low back pain and even injury. In the present study, researchers performed a quantitative assessment of trunk postures using an inertial measurement unit (IMU)-based kinematic measurement system while workers lifted kegs at a craft brewery. Results of this field-based study indicated that during keg handling, craft brewery workers exhibited awkward and non-neutral trunk postures. Based on the results of the posture data, design recommendations were identified to reduce the hazardous exposure for musculoskeletal disorders among craft brewery workers.
Computer Education and Third Age Universities: A Systematic Review
Authors: Sobral Sónia Rolland , Sobral Margarida
Published: July 2021

An aging population and a digital society are realities. There is a need to equip older people with knowledge and computer skills so that they can participate in society, without feeling excluded or being marginalized. Third age universities are organizations around the world that specialize in teaching and learning for senior students in a more informal and more integrated way than other educational institutions. The objective of this study was to identify the existing quality publications that deal with the subject of computer education at senior universities. The SCOPUS and Web of Science databases were used, and 18 records were found according to the adopted criteria. It was found that these articles, depending on their focus, can be divided into four groups: educators, organizations/directors, students, and conceptual/review papers. Through these articles, it was possible to draw a picture of what older people’s computer learning is like, what barriers exist for students to not be able to attend these classes, as well as tips on how courses should be organized and the pedagogical methodologies that must be adopted. It is intended that this article is used as a good tool for people who work in teaching information technology to the elderly, and especially for course directors who intend to create or reformulate courses of this type for this specific age group.
Analysis of Parenting Attitude Types and Influencing Factors of Korean Parents by Using Latent Transition Analysis
Authors: Lee Hanna , Han Jeong-Won
Published: July 2021

This study aimed to classify the latent class of parenting attitude for parents with preschool children and school-age children, identify the pattern of transition in the type of parenting attitude over time, and determine the influencing factors associated with the transition. A total of 1462 households were the subjects of this longitudinal study that used latent profile analysis, latent transition analysis, and logistic regression analysis. The parenting attitude in the preschool year was classified into a model of three latent classes of ‘parent uninvolved’, ‘maternal authoritative and paternal authoritarian’, and ‘maternal authoritarian and paternal authoritative’, and the parenting attitude in the school year was classified into a model of four latent classes of ‘parent weak uninvolved’, ‘parent strong uninvolved’, parent authoritative’, and ‘maternal authoritarian and paternal authoritative.’ All latent class subjects with preschool children showed an attitude transition to maternal authoritarian and paternal authoritative when their children were in school years. It was confirmed that a mother’s depression and father’s parenting stress were the most influential factors in the parenting attitude transition. This study lay in identifying the patterns of parenting attitude and the transition in attitude according to the developmental stage of children.
Corporate Social Responsibility Disclosure: Responding to Investors’ Criticism on Social Media
Authors: Zhang Yuming , Yang Fan
Published: July 2021

Companies use corporate social responsibility (CSR) disclosures to communicate their social and environmental policies, practices, and performance to stakeholders. Although the determinants and outcomes of CSR activities are well understood, we know little about how companies use CSR communication to manage a crisis. The few relevant CSR studies have focused on the pressure on corporations exerted by governments, customers, the media, or the public. Although investors have a significant influence on firm value, this stakeholder group has been neglected in research on CSR disclosure. Grounded in legitimacy theory and agency theory, this study uses a sample of Chinese public companies listed on the Shanghai Stock Exchange to investigate CSR disclosure in response to social media criticism posted by investors. The empirical findings show that investors’ social media criticism not only motivates companies to disclose their CSR activities but also increases the substantiveness of their CSR reports, demonstrating that companies’ CSR communication in response to a crisis is substantive rather than merely symbolic. We also find that the impact of social media criticism on CSR disclosure is heterogeneous. Non-state-owned enterprises, companies in regions with high levels of environmental regulations, and companies in regions with local government concern about social issues are most likely to disclose CSR information and report substantive CSR activities. We provide an in-depth analysis of corporate CSR strategies for crisis management and show that crises initiated by investors on social media provide opportunities for corporations to improve their CSR engagement.
Innovations in Social and Emotional Learning Research and Practice: Building from Evidence and Applying Behavioral Insights to the Design of a Social and Emotional Learning Intervention in Northeast Nigeria
Authors: Bailey Rebecca , Raisch Natasha , Temko Sonya , Titus Britt , Bautista Jonah , Eniola Tahirat Omolara , Jones Stephanie M.
Published: July 2021

Recent studies suggest that social and emotional learning (SEL) programming has the potential to be effective in conflict-affected regions, yet evidence is limited, and findings to date are mixed. One hypothesis about why SEL interventions in education in emergencies (EiE) settings have not generated the anticipated results is that the SEL content and materials have not been sufficiently localized to the context, leading to poor cultural relevance or fit. A second hypothesis is that SEL program demands tend to be high and capacity for implementation is low, undermining sustainability and impact. The current study addresses these challenges by investing in locally driven SEL content and design as a way to ensure that SEL materials are grounded in local values and needs, culturally appropriate, relevant to the specific context, and feasible to implement. The study draws on the developmental and prevention sciences as well as the field of behavioral insights to test evidence-based interventions intended to encourage desired behaviors around uptake and implementation. This paper documents the activities conducted during the project’s design phase, including landscape research, creation of initial prototypes, design workshops and rapid prototyping, and field testing. Findings suggest that using local values, practices, and framing in SEL programming increases relevance and appropriateness for the Northeast Nigeria setting. Furthermore, targeted behavioral insights interventions increased the uptake, habitual and regular use, as well as correct implementation of SEL activities. The findings contribute to the emerging literature on the cultural variability of SEL and the need to consider the context when designing and implementing programs in any setting.
Influence of Face Masks on the Use of Contact Lenses
Authors: Martinez-Perez Clara , Monteiro Bruno , Soares Mafalda , Portugues Fatima , Matos Sonia , Ferreira Ana , Alvarez-Peregrina Cristina , Sánchez-Tena Miguel Ángel
Published: July 2021

Background: The COVID-19 epidemic is largely controlled by the use of face masks. The use of a face mask has been indicated as a strong cause of dry eye, although it is not yet described in the literature. This study aims to compare the impact of the use of masks on the visual quality of patients. The symptoms in the human eye intensified during the pandemic versus the symptoms before the pandemic, in a Portuguese population. Methods: A fifteen-question questionnaire was conducted to find out what changes occurred in the use of soft contact lenses during the pandemic in relation to the use of masks. Statistical analysis was performed with SPSS 27.0 software (SPSS Inc., Chicago, IL, USA). Results: The use of contact lenses decreased compared with before the pandemic (p < 0.001). The number of hours of wear decreased significantly compared with before the pandemic (p < 0.001). The sensation of dry eyes was found to be worse in those using monthly replacement contact lenses (p = 0.034), and the need to remove contact lenses was more frequent in women (p = 0.026) after using a mask. Conclusions: Mask use increases dry eye symptoms in contact lens wearers, negatively impacting visual quality.
Subjective Well-Being and Parenthood in Chile
Authors: Novoa Consuelo , Bustos Claudio , Bühring Vasily , Oliva Karen , Páez Darío , Vergara-Barra Pablo , Cova Félix
Published: July 2021

Being a parent plays an important role in people’s life trajectory and identity. Though the general cultural perception is that having children is a source of subjective well-being, there is evidence that, at least in some societies, the subjective well-being of those who are parents is worse, in some aspects, than that of those who are not. This gap has been the object of interest and controversy. The aim of this study was to compare Chilean adults with and without children in a broad set of well-being indicators, controlling for other sociodemographic variables. A public national probabilistic database was used. The results show that, in terms of positive and negative affect, those who are not parents achieve greater well-being than those who have children. Other results also pointed in that direction. The implications of the social context and gender, which are aspects that pose a burden for the exercise of parenthood in Chile, are discussed.
How Can We Develop an Efficient eHealth Service for Provision of Care for Elderly People with Balance Disorders and Risk of Falling? A Mixed Methods Study
Authors: Gaspar Andréa Gomes Martins , Escada Pedro , Lapão Luís Velez
Published: July 2021

This study aimed to identify relevant topics for the development of an efficient eHealth service for elderly people with balance disorders and risk of falling, based on input from physicians providing healthcare to this patient group. In the quantitative part of the study, an open multiple-choice questionnaire was made available on the website of the Portuguese General Medical Council to assess the satisfaction with electronic medical records regarding clinical data available, the time needed to retrieve data and the usefulness of the data. Of the 118 participants, 55% were dissatisfied/very dissatisfied with data availability and 61% with the time spent to access and update data related to the focused patient group. Despite this negative experience, 76% considered future e-Health solutions as pertinent/very pertinent. Subsequently, these findings were further explored with eight semi-structured interviews. The physicians confirmed the reported dissatisfactions and pointed out the lack of comprehensive data and system interoperability as serious problems, causing inefficient health services with an overlap of emergency visits and uncoordinated diagnostics and treatment. In addition, they discussed the importance of camera and audio monitoring to add significant value. Our results indicate considerable potential for e-Health solutions, but substantial improvements are crucial to achieving such future solutions.
Going “Up” to Move Forward: S-1 Bifactor Models and the Study of Neurocognitive Abilities in Psychopathology
Authors: Haywood Darren , Baughman Frank D. , Mullan Barbara A. , Heslop Karen R.
Published: July 2021

Recently, structural models of psychopathology, that address the diagnostic stability and comorbidity issues of the traditional nosological approach, have dominated much of the psychopathology literature. Structural approaches have given rise to the p-factor, which is claimed to reflect an individual’s propensity toward all common psychopathological symptoms. Neurocognitive abilities are argued to be important to the development and maintenance of a wide range of disorders, and have been suggested as an important driver of the p-factor. However, recent evidence argues against p being an interpretable substantive construct, limiting conclusions that can be drawn from associations between p, the specific factors of a psychopathology model, and neurocognitive abilities. Here, we argue for the use of the S-1 bifactor approach, where the general factor is defined by neurocognitive abilities, to explore the association between neurocognitive performance and a wide range of psychopathological symptoms. We use simulation techniques to give examples of how S-1 bifactor models can be used to examine this relationship, and how the results can be interpreted.
Tropical Coastal Land-Use and Land Cover Changes Impact on Ecosystem Service Value during Rapid Urbanization of Benin, West Africa
Authors: Tiando Damien Sinonmatohou , Hu Shougeng , Fan Xin , Ali Muhammad Rashid
Published: July 2021

West African coastal areas including the Beninese coastal zones have undergone an intensification of socio-economic activity in the last few decades that has been strongly driven by the effects of rapid urbanization. This has led to land-use and land cover changes that represent threats to the sustainability of various ecosystem functions. Such dynamics of land use and land cover changes pose challenges to coastal zone management. Correct assessment is vital for policymakers and planners to ensure efficient and sustainable use of the coastal ecosystem services, and it remains crucial to achieving sustainable coastal zone management. This study examines changes in land-use and land cover (LULC) and their impacts on ecosystem services value (ESV) fluctuations in the tropical coastal region of Benin, West Africa. We employed Globe Land 30 image data for the years 2010 and 2020, and the ESV fluctuations during the study period were evaluated using the benefit transfer approach (BTA) with corresponding local coefficients values and the GIS techniques. The results reveal that (1) in the current urbanizing coastal area, the LULC types have changed significantly, with obvious reductions in forest land and waterbodies and a considerable increase in artificial surfaces; (2) the total ESV decreased by 8.51% from USD 7.1557 million in 2010 to USD 6.5941 million in 2020; (3) the intensity of LULC in the coastal region has increased over the last 10 years; (4) regions with high land-use intensity have a high rate of ESV change; and (5) provisioning services are the greatest contributors of ESV (51% in 2010; 41% in 2020), followed by supporting services (37% in 2010; 35% in 2020) and regulating services (25% in 2010; 30% in 2020). Uncontrolled changes in LULC from forest land and waterbodies are the main causes of the loss in total ESV, necessitating urgent measures to improve the coastal ecosystem sustainability through effective planning and policies.
Perceiving Residents’ Festival Activities Based on Social Media Data: A Case Study in Beijing, China
Authors: Wang Bingqing , Meng Bin , Wang Juan , Chen Siyu , Liu Jian
Published: July 2021

Social media data contains real-time expressed information, including text and geographical location. As a new data source for crowd behavior research in the era of big data, it can reflect some aspects of the behavior of residents. In this study, a text classification model based on the BERT and Transformers framework was constructed, which was used to classify and extract more than 210,000 residents’ festival activities based on the 1.13 million Sina Weibo (Chinese “Twitter”) data collected from Beijing in 2019 data. On this basis, word frequency statistics, part-of-speech analysis, topic model, sentiment analysis and other methods were used to perceive different types of festival activities and quantitatively analyze the spatial differences of different types of festivals. The results show that traditional culture significantly influences residents’ festivals, reflecting residents’ motivation to participate in festivals and how residents participate in festivals and express their emotions. There are apparent spatial differences among residents in participating in festival activities. The main festival activities are distributed in the central area within the Fifth Ring Road in Beijing. In contrast, expressing feelings during the festival is mainly distributed outside the Fifth Ring Road in Beijing. The research integrates natural language processing technology, topic model analysis, spatial statistical analysis, and other technologies. It can also broaden the application field of social media data, especially text data, which provides a new research paradigm for studying residents’ festival activities and adds residents’ perception of the festival. The research results provide a basis for the design and management of the Chinese festival system.
Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis
Authors: Amor López Ana , Mazariegos Marina S. , Capuano Alessandra , Ximénez-Embún Pilar , Hergueta-Redondo Marta , Recio Juan Ángel , Muñoz Eva , Al-Shahrour Fátima , Muñoz Javier , Megías Diego , Doliana Roberto , Spessotto Paola , Peinado Héctor
Published: July 2021

Several studies have demonstrated that melanoma-derived extracellular vesicles (EVs) are involved in lymph node metastasis; however, the molecular mechanisms involved are not completely defined. Here, we found that EMILIN-1 is proteolyzed and secreted in small EVs (sEVs) as a novel mechanism to reduce its intracellular levels favoring metastasis in mouse melanoma lymph node metastatic cells. Interestingly, we observed that EMILIN-1 has intrinsic tumor and metastasis suppressive-like properties reducing effective migration, cell viability, primary tumor growth, and metastasis. Overall, our analysis suggests that the inactivation of EMILIN-1 by proteolysis and secretion in sEVs reduce its intrinsic tumor suppressive activities in melanoma favoring tumor progression and metastasis.
The Role of Dietary Nutrients in Peripheral Nerve Regeneration
Authors: El Soury Marwa , Fornasari Benedetta Elena , Carta Giacomo , Zen Federica , Haastert-Talini Kirsten , Ronchi Giulia
Published: July 2021

Peripheral nerves are highly susceptible to injuries induced from everyday activities such as falling or work and sport accidents as well as more severe incidents such as car and motorcycle accidents. Many efforts have been made to improve nerve regeneration, but a satisfactory outcome is still unachieved, highlighting the need for easy to apply supportive strategies for stimulating nerve growth and functional recovery. Recent focus has been made on the effect of the consumed diet and its relation to healthy and well-functioning body systems. Normally, a balanced, healthy daily diet should provide our body with all the needed nutritional elements for maintaining correct function. The health of the central and peripheral nervous system is largely dependent on balanced nutrients supply. While already addressed in many reviews with different focus, we comprehensively review here the possible role of different nutrients in maintaining a healthy peripheral nervous system and their possible role in supporting the process of peripheral nerve regeneration. In fact, many dietary supplements have already demonstrated an important role in peripheral nerve development and regeneration; thus, a tailored dietary plan supplied to a patient following nerve injury could play a non-negotiable role in accelerating and promoting the process of nerve regeneration.
Saccharomyces cerevisiae, a Powerful Model for Studying rRNA Modifications and Their Effects on Translation Fidelity
Authors: Baudin-Baillieu Agnès , Namy Olivier
Published: July 2021

Ribosomal RNA is a major component of the ribosome. This RNA plays a crucial role in ribosome functioning by ensuring the formation of the peptide bond between amino acids and the accurate decoding of the genetic code. The rRNA carries many chemical modifications that participate in its maturation, the formation of the ribosome and its functioning. In this review, we present the different modifications and how they are deposited on the rRNA. We also describe the most recent results showing that the modified positions are not 100% modified, which creates a heterogeneous population of ribosomes. This gave rise to the concept of specialized ribosomes that we discuss. The knowledge accumulated in the yeast Saccharomyces cerevisiae is very helpful to better understand the role of rRNA modifications in humans, especially in ribosomopathies.
Modern Urban Transport Infrastructure Solutions to Improve the Safety of Children as Pedestrians and Cyclists
Authors: Cieśla Maria
Published: July 2021

This article presents the issues and needs for modern solutions in building urban infrastructure, based on the smart city idea to improve the living standards of residents. Particular attention is paid to one of the most important aspects of life, related to road safety of children as pedestrians and cyclists. Pedestrian sidewalks and bicycle paths with high pedestrian traffic are classified as dangerous areas in many countries. More than 3% of the injuries and fatalities among pedestrian road users that are victims of accidents occur due to crossing the road. Therefore, it is necessary to apply various technical infrastructure solutions to improve the safety of this group of inhabitants. The scientific purpose of this article is the assessment of the safety level of children in pedestrian and bicycle traffic and the analysis of road solutions supporting the maintenance of high-level city safety. The research was based on the analysis of statistical data of accidents and the diagnostic survey method determining the safety of the inhabitants of southern Poland. As a result, an analysis of the level of child safety in urban traffic was developed, as well as key factors affecting the levels of road safety, based on the opinions of respondents. Potential places with the greatest risk of collision with minors have also been identified. There are also proposals for infrastructure solutions aimed at minimising accident risk levels in designated areas.
Increased Mortality in Elderly Patients Admitted with Hyponatremia: A Prospective Cohort Study
Authors: Ioannou Petros , Panagiotakis Symeon , Tsagkaraki Emmanouela , Tsioutis Constantinos , Fragkiadakis Konstantinos , Gikas Achilleas , Filippatos Theodosios D.
Published: July 2021

Hyponatremia is the most common electrolyte disorder, commonly affecting older hospitalized individuals; however, the literature is not clear regarding its effect on mortality. The aim of this 2-year observational prospective cohort study was to evaluate the mortality and re-admission rates, the clinical and laboratory characteristics and the causes of hyponatremia in patients older than 65 years admitted with a corrected serum sodium of 130 mEq/L or less in an internal medicine ward of a tertiary Greek university hospital. During the observation period, 138 patients (mean age 80.5 years, 36.2% male) fulfilled the inclusion criteria and were prospectively followed for 1 year after admission. Symptoms of hyponatremia were present in 59.4% of patients. Hypovolemia was the main sole cause of hyponatremia, but in about one third of patients, hyponatremia was multifactorial. Only a low proportion of patients (12.3%) fulfilled the criteria of the syndrome of inappropriate antidiuresis (SIAD) at admission according to the current guidelines. The re-admission rates at 3- and 12-months following discharge was 34.2% and 51.8%, respectively. Mortality during hospitalization was 17.4% and was higher compared to non-hyponatremic admitted older patients, while the total mortality at 1 year after admission was 28.3%, indicating that hyponatremia at admission is a marker of significant mortality during and after hospitalization in elderly patients.
Dysregulated Tear Film Proteins in Macular Edema Due to the Neovascular Age-Related Macular Degeneration Are Involved in the Regulation of Protein Clearance, Inflammation, and Neovascularization
Authors: Winiarczyk Mateusz , Winiarczyk Dagmara , Michalak Katarzyna , Kaarniranta Kai , Adaszek Łukasz , Winiarczyk Stanisław , Mackiewicz Jerzy
Published: July 2021

Macular edema and its further complications due to the leakage from the choroidal neovascularization in course of the age-related macular degeneration (AMD) is a leading cause of blindness among elderly individuals in developed countries. Changes in tear film proteomic composition have been reported to occur in various ophthalmic and systemic diseases. There is an evidence that the acute form of neovascular AMD may be reflected in the tear film composition. Tear film was collected with Schirmer strips from patients with neovascular AMD and sex- and age-matched control patients. Two-dimensional electrophoresis was performed followed by MALDI-TOF mass spectrometry for identification of differentially expressed proteins. Quantitative analysis of the differential electrophoretic spots was performed with Delta2D software. Altogether, 11 significantly differentially expressed proteins were identified; of those, 8 were downregulated, and 3 were upregulated in the tear film of neovascular AMD patients. The differentially expressed proteins identified in tear film were involved in signaling pathways associated with impaired protein clearance, persistent inflammation, and neovascularization. Tear film protein analysis is a novel way to screen AMD-related biomarkers.
Ultrasound-Guided Near-Nerve Needle Sensory Technique for the Diagnosis of Tarsal Tunnel Syndrome
Authors: Vega-Zelaya Lorena , Iborra Álvaro , Villanueva Manuel , Pastor Jesús , Noriega Concepción
Published: July 2021

Background: Tarsal tunnel syndrome (TTS) is one of the most common entrapment syndromes. Although diagnosis is supported by imaging tests, it has so far been based on clinical findings. Neurophysiological tests are not effective for providing an accurate diagnosis. The objective of this study was to analyze the efficacy of the ultrasound-guided near-nerve needle sensory technique (USG-NNNS) for the diagnosis of TTS Methods: The study population comprised 40 patients referred for a neurophysiological study owing to clinical suspicion of TTS. Routine neurophysiological tests were performed and compared with the results of USG-NNNS. Results: The diagnosis of TTS was achieved in 90% of cases. We found significant differences between lateral plantar sensory recordings with surface electrodes and USG-NNNS techniques for amplitude, nerve conduction velocity (NCV), and duration. As for the medial plantar sensory recordings, differences were found only for duration. No responses were obtained with surface electrode studies in 64.8% of cases. In addition, we observed normal sensory NCV with surface electrodes in 20 patients, although this decreased when the NNNS technique was used. Conclusions: This is the first report of the efficacy of the USG-NNNS technique for confirming the diagnosis of TTS.
Bicuspid Aortic Valve Is Associated with Less Coronary Calcium and Coronary Artery Disease Burden
Authors: Feuchtner Gudrun , Bleckwenn Sven , Stoessl Leon , Plank Fabian , Beyer Christoph , Bonaros Nikolaos , Schachner Thomas , Senoner Thomas , Widmann Gerlig , Gollmann-Tepeköylü Can , Holfeld Johannes , Dichtl Wolfgang , Barbieri Fabian
Published: July 2021

(1) Background. Bicuspid aortic valve (BAV) is associated with genetic defects (NOTCH 1, GATA 5) and aortopathy. Differences in the flow patterns and a genetic predisposition could also affect coronary arteries. The objective was to assess the coronary artery calcium score (CACS) and coronary artery disease (CAD) burden by coronary computed tomography angiography (CTA) in patients with BAV stenosis, as compared to stenotic tricuspid aortic valves (TAV). (2) Methods. A retrospective case–control study. A total of 47 patients with BAV stenosis (68.9 years ± 12.9, 38.3% females) who underwent CTA were matched with 47 TAV stenosis patients for age, gender, smoking, arterial hypertension, dyslipidemia, diabetes, body-mass-index and chronic kidney disease. (3) Results. The coronary artery calcium score (CACS) was lower in BAV (237.4 vs. 1013.3AU; p < 0.001) than in TAV, and stenosis severity was less (CAD-RADTM: p < 0.001). More patients with BAV had CACS zero (27.7% vs. 0%; p < 0.001). The majority (68.1%) of patients with BAV had no or non-obstructive CAD but only 25.5% of TAV (p < 0.001). Obstructive CAD (>50% stenosis) by CTA was more frequently observed in patients with TAV (68.1%; p < 0.001). (4) Conclusions and Relevance. Patients with BAV stenosis have markedly less coronary calcium and less severe coronary stenosis. CTA succeeds to rule out obstructive CAD in the majority of BAV, with adherent implications for TAVR planning.
Effects of Electron Beam Irradiation on 3D-Printed Biopolymers for Bone Tissue Engineering
Authors: Mastalerz Conrad , Vroman Isabelle , Coqueret Xavier , Alix Sébastien
Published: July 2021

Implanting scaffolds designed for the regeneration or the replacement of bone tissue damaged by diseases and injuries requires specially designed biomaterials that promote cell adhesion. However, the biodegradation rate of these scaffolds based on a single material is uniform. Four-dimensional printing appears to be a promising method to control this aspect by changing the shape and/or the intrinsic properties of 3D-printed objects under the influence of external stimuli. Two main classes of biomaterials and biocomposites based on biopolyesters, namely poly(lactic acid) (PLA) and poly(caprolactone) (PCL), were used in this study. Each of them was mixed with the inorganic filler hydroxyapatite (HA), which is a component of natural bone. The biocomposites and biomaterials were prepared using the melt extrusion process and then shaped using a 3D printer. Three-dimensional specimens showed a decrease in elongation at break and breaking strain due to variations of crystallinity. The crystallinity of irradiated samples increased slightly with irradiation and a new crystalline phase was observed in the case of the PLA. Four-dimensional printing of biomaterials using electron radiation shows great promise for bone tissue engineering based on biocomposite scaffolds and other medical applications.
No-Reference Image Quality Assessment with Multi-Scale Orderless Pooling of Deep Features
Authors: Varga Domonkos
Published: July 2021

The goal of no-reference image quality assessment (NR-IQA) is to evaluate their perceptual quality of digital images without using the distortion-free, pristine counterparts. NR-IQA is an important part of multimedia signal processing since digital images can undergo a wide variety of distortions during storage, compression, and transmission. In this paper, we propose a novel architecture that extracts deep features from the input image at multiple scales to improve the effectiveness of feature extraction for NR-IQA using convolutional neural networks. Specifically, the proposed method extracts deep activations for local patches at multiple scales and maps them onto perceptual quality scores with the help of trained Gaussian process regressors. Extensive experiments demonstrate that the introduced algorithm performs favorably against the state-of-the-art methods on three large benchmark datasets with authentic distortions (LIVE In the Wild, KonIQ-10k, and SPAQ).
FTSMAC: A Multi-Channel Hybrid Reader Collision Avoidance Protocol for RFID Network
Authors: Mafamane Rachid , Ait Mansour Asmae , Ouadou Mourad , Minaoui Khalid
Published: July 2021

Due to the emergence of the Internet of Things, the need for effective identification and traceability has increased. Radio-frequency identification (RFID), a simple and cheap approach for gathering information, has therefore drawn the attention of research communities. However, this system suffers from problems caused by high density, such as collisions and duplication. Thus, the deployment of RFID is more effective in a dense environment where it may improve overage and delays. A wide range of solutions have been proposed; however, the majority of these are based on the application context. In this paper, we propose a general MAC layer protocol FTSMAC (Frequency Time Scheme MAC) in which the spectrum frequency is efficiently used by dividing the signal into different time slots via a messaging mechanism used by RFID readers. This limits the collisions in high-density RFID deployment that affect the performance of the system. Thus, our solution allows the communication system to converge to a stable state within a convenient time.
Urban versus Rural? Conflict Lines in Land Use Disputes in the Urban–Rural Fringe Region of Schwerin, Germany
Authors: Fienitz Meike , Siebert Rosemarie
Published: July 2021

Land use conflicts can present major obstacles to sustainable land management. An accurate understanding of their actor constellations and conflict lines is therefore crucial in developing tools for successful landscape governance. In this context, actors from cities and actors from rural areas are often seen as typical opponents. Hence, the objective of this paper is to analyze the extent to which empirical conflict lines indeed run between urban and rural actors. We applied qualitative text analysis to examine 124 land use conflicts in the urban–rural fringe of Schwerin, Germany, which were identified through semistructured interviews with key land use actors in the region. Results showed that actors from the city and the rural fringe were on opposing sides in almost half of the conflicts. However, they were also frequently in conflict among themselves, and many actor constellations involved actors from other regions or administrative levels. In conclusion, the narrative of the urban–rural dichotomy appears in the empirical data but does not appropriately convey the complexity of the actual conflict lines. The findings of this paper therefore emphasize that it is important to empirically identify the actor constellations in land use conflicts rather than rely on preconceived ideas about typical conflict lines.
Preparation and Characterization of Physicochemical Properties of Spruce Cone Biochars Activated by CO2
Authors: Jedynak Katarzyna , Charmas Barbara
Published: July 2021

In this study the pyrolysis of Norway spruce cones, a lignocellulosic biomass was made. The biochar product was obtained by means of the physical activation method. CO2 was used as the activating gas. The surface properties of biochars were characterized by the nitrogen adsorption/desorption isotherms, scanning electron microscopy (SEM/EDS), X-ray fluorescence energy dispersion spectroscopy (ED-XRF), thermal analysis (TGA/DTA), infrared spectroscopy (ATR FT-IR), Raman spectroscopy and the Boehm’s titration method as well as the point of zero charge (pHpzc). The adsorption capacity and the possibility of ammonia desorption (TPD) were also examined. It has been shown that spruce cones can be successfully used as a cheap precursor of well-developed surface biochars, characterized by a large pore volume and good sorption properties. All obtained activated biochars exhibit a largely microporous structure and an acidic character surface. The investigated activated materials have the specific surface areas from 112 to 1181 m2 g−1. The maximum NH3 adsorption capacity of the activated biochar was determined to be 5.18 mg g−1 (88.22 mmol g−1) at 0 °C. These results indicate the applicability of spruce cones as a cheap precursor for the sustainable production of the cost-effective and environmentally friendly biochar adsorbent.
New Biocomposite Electrospun Fiber/Alginate Hydrogel for Probiotic Bacteria Immobilization
Authors: Grzywaczyk Adam , Zdarta Agata , Jankowska Katarzyna , Biadasz Andrzej , Zdarta Jakub , Jesionowski Teofil , Kaczorek Ewa , Smułek Wojciech
Published: July 2021

Biotechnological use of probiotic microorganisms involves providing them with appropriate conditions for growth, but also protection against environmental changes caused by an exchange of the medium, isolation of metabolites, etc. Therefore, the research on effective immobilization of probiotic microorganisms should be focused in this direction. The present study aimed to evaluate the effectiveness of an innovative hybrid immobilization system based on electrospun nanofibers and alginate hydrogel. The analyses carried out included the study of properties of the initial components, the evaluation of the degree and durability of cell immobilization in the final material, and their survival under stress conditions. Effective binding of microorganisms to the hydrogel and nanofibers was confirmed, and the collected results proved that the proposed biocomposite is an efficient method of cell protection. In addition, it was shown that immobilization on electrospun nanofibers leads to the preservation of the highest cell activity and the least cell growth restriction as compared to free or lyophilized cells only. The completed research opens new perspectives for the effective immobilization of microorganisms of significant economic importance.
Applying Mixture of Municipal Incinerator Bottom Ash and Sewage Sludge Ash for Ceramic Tile Manufacturing
Authors: Lin Deng-Fong , Wang Wei-Jhu , Chen Chia-Wen , Lin Kuo-Liang
Published: July 2021

Municipal incinerator bottom ash (MIBA) and sewage sludge ash (SSA) are secondary wastes produced from municipal incinerators. Landfills, disposal at sea, and agricultural use have been the major outlets for these secondary wastes. As global emphasis on sustainability arises, many have called for an increasing reuse of waste materials as valuable resources. In this study, MIBA and SSA were mixed with clay for ceramic tile manufacturing in this study. Raw materials firstly went through TCLP (Toxicity Characteristic Leaching Procedure) to ensure their feasibility for reuse. From scanning electron microscopy (SEM), clay’s smooth surface was contrasted with the porous surface of MIBA and SSA, which led to a higher water requirement for the mixing. Specimens with five MIBA mix percentages of 0%, 5%, 10%, 15%, and 20% (wt) and three SSA mix percentages of 0%, 10%, and 20% (wt) were made to compare how the two waste materials affected the quality of the final product and to what extent. Shrinkage tests showed that MIBA and SSA contributed oppositely to tile shrinkage, as more MIBA reduced tile shrinkage, while more SSA encouraged tile shrinkage. However, as the kiln temperature reached 1150 °C, the SiO2-rich SSA adversely reduced the shrinkage due to the glass phase that formed to expand the tile instead. Both MIBA and SSA increased water tile absorption and reduced its bending strength and wear resistance. Increasing the kiln temperature could effectively improve the water absorption, bending strength, and wear resistance of high MIBA and SSA mixes, as SEM showed a more compact structure at higher temperatures. However, when the temperature reached 1100 °C, more pores appeared and seemingly exhausted the benefit brought by the higher temperature. Complex interactions between kiln temperature and MIBA/SSA mix percentage bring unpredictable performance of tile shrinkage, bending strength, and water absorption, which makes it very challenging to create a sample meeting all the specification requirements. We conclude that a mix with up to 20% of SSA and 5% of MIBA could result in quality tiles meeting the requirements for interior or exterior flooring applications when the kiln temperature is carefully controlled.