bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosis of dizziness in the emergency department: A 1-year prospective single-center study
Authors: Nouini Adrâa , Mat Quentin , Van Nechel Christian , Bostan Alionka , Dachy Bernard , Ourtani Anissa
Published: March 2023

BACKGROUND: The management of dizziness and vertigo can be challenging in the emergency department (ED). It is important to rapidly diagnose vertebrobasilar stroke (VBS), as therapeutic options such as thrombolysis and anticoagulation require prompt decisions. OBJECTIVE: This study aims to assess the rate of misdiagnosis in patients with dizziness caused by VBS in the ED. METHODS AND RESULTS: The cohort was comprised of 66 patients with a mean age 56 years; 48% were women and 52% men. Among dizzy patients, 14% had VBS. We used Cohen’s kappa test to quantify the agreement between two raters –namely, emergency physicians and neurologists –regarding the causes of dizziness in the ED. The Kappa value was 0.27 regarding the final diagnosis of central vertigo disorders and VBS, thus showing the low agreement. We used the χi2 test to show the association between the presence of two or more cardiovascular risk factors and admission to the stroke unit (p = 0.015). CONCLUSION: There is a substantial rate of misdiagnosis in patients with dizziness caused by VBS in the ED. To reduce the number of missing diagnoses of VBS in the future, there is a need to train emergency physicians in neurovestibular examinations, including the HINTS examination for acute vestibular syndrome (AVS) and the Dix-Hallpike (DH) maneuver for episodic vestibular syndrome. Using video head impulse test could help reduce the rate of misdiagnosis of VBS in the ED.
O custo médico das faltas dos utentes da USF Ramada
Authors:   Médico Interno de Medicina Geral e Familiar USF Ramada, Pedrosa Bruno Ferreira
Published: March 2023

Objetivos: Correlacionar as faltas dos utentes da USF Ramada às consultas médicas programadas no ano de 2019 e o custo associado. Tipo de estudo: Observacional retrospetivo. Local: USF Ramada. População: Consultas médicas programadas da USF Ramada em 2019. Métodos: A amostra foi calculada a partir do total de vagas para consultas médicas programadas em 2019 da USF Ramada. Uma amostra de 1.000 consultas foi selecionada de forma aleatória simples. Foi realizada uma análise descritiva dos dados, um teste binomial para correlacionar as variáveis biossociais com o número de faltas e tempo de consulta atribuído e uma análise bivariada e das variâncias para estabelecer a homogeneidade entre os grupos de utentes de cada médico. Foi calculado o custo médico das faltas. Resultados: Encontraram-se 128 faltas (12,8%). A média de idades foi de 45,09 anos (DP=21,6), sendo 57% por utentes do sexo feminino. Não se verificou diferença estatisticamente significativa entre os dois sexos para o número de faltas (p=0,133) ou para o tempo de consulta perdido (p=0,500). A média de faltas para cada médico foi de 13,2% (DP=3,89). O tempo total de consulta perdido foi de 2.440 minutos, o que em média corresponde a 271,11 minutos (DP=18,87) por médico e a 19,06 minutos (DP=5,67) por consulta. Foi estabelecida a homogeneidade entre os grupos de doentes faltosos de cada médico para o sexo (p=0,471), idade (p=0,778) e tempo de consulta perdido (p=0,609). O custo médico calculado das faltas dos utentes foi de 770,20 euros. Conclusões: Estimou-se, para o ano de 2019 na USF Ramada, um custo médico evitável entre 18.418,82 e 32.169,42 euros por faltas dos utentes a consultas programadas.
Uma fratura femoral atípica: relato de caso
Authors:   USF Nova Via, ACeS Espinho/Gaia, Vaz Teresa Raquel , Sá Luísa ,   USF Nova Via, ACeS Espinho/Gaia
Published: March 2023

Introdução: A osteoporose é a doença metabólica mais comum do osso e os bifosfonatos são o seu tratamento de primeira linha. Apesar de eficazes a reduzir o risco de fraturas osteoporóticas têm surgido relatos de fraturas atípicas do fémur aparentemente relacionadas com a terapêutica prolongada com estes fármacos. Descrição do caso: Apresenta-se o caso de uma doente de 78 anos, diagnosticada há 21 anos com osteoporose. Ao diagnóstico foi medicada com ácido ibandrónico 150mg mensal. Em 2007 foi feito switch terapêutico para ácido alendrónico 70mg + colecalciferol 2800 U.I., semanal, o qual mantém desde então, perfazendo treze anos de terapêutica com esse fármaco. Foi transportada ao serviço de urgência de ortopedia na sequência de um trauma de baixa energia, do qual resultou uma fratura subtrocantéria do fémur esquerdo. Comentário: A relação causal entre o uso prolongado de bifosfonatos e as fraturas atípicas do fémur ainda não está estabelecida. Contudo, esta associação não deve ser ignorada, sendo essencial avaliar os riscos e benefícios antes de iniciar o tratamento, bem como promover uma vigilância ativa dos pacientes sob terapêutica prolongada com bifosfonatos. Os estudos reportam que mais de metade dos doentes que sofrem uma fratura atípica do fémur têm pródromos de dor na coxa ou na virilha, o que ocorreu no caso relatado, pelo que são sintomas que devem ser valorizados e ativamente questionados, sobretudo nos doentes medicados com bifosfonatos. Independentemente deste risco potencial, os bifosfonatos continuam a ser os fármacos de primeira linha para a prevenção de fraturas osteoporóticas, devendo a duração do tratamento ser individualizada.
Referenciação aos cuidados de saúde secundários em idade adulta: protocolo de estudo coorte retrospetivo
Authors:   USF Tondela, Ferraz Rui , Rosário Frederico ,   USF Tondela
Published: March 2023

Objetivos: estimar a taxa de referenciação à consulta externa do Centro Hospitalar Tondela Viseu (CHTV), na idade adulta; avaliar a qualidade das referenciações realizadas pelos médicos de família (MF), com base no “Guia de Referenciação do ACeS Dão Lafões à Consulta Externa do Centro Hospitalar Tondela-Viseu” (GR); comparar referenciações entre as unidades funcionais participantes; analisar os tempos de resposta do CHTV às referenciações; avaliar a existência de informação de retorno para o MF após a alta. Métodos: Este protocolo de estudo coorte retrospetivo multicêntrico será implementado em 6 unidades do ACeS Dão Lafões, bem como no CHTV e terá como população estudada os utentes inscritos nas unidades envolvidas, com 18 ou mais anos de idade em janeiro de 2018. Será selecionada aleatoriamente uma amostragem de 8000 observações. Serão avaliadas as referenciações realizadas para o CHTV no ano de 2018. Os dados serão colhidos por consulta do processo clínico das USFs e do CHTV. Variáveis estudadas: sexo, idade, unidade funcional, utilizador, número de referenciações, taxa de referenciação por consulta, taxa de utilizadores referenciados, taxa de referenciação por utente utilizador, consulta pedida, qualidade das cartas, tempo até à resposta, caracterização da resposta, avaliação das respostas, tempo até à consulta hospitalar, informação de retorno. O estudo será realizado no último trimestre de 2021. Discussão: Os resultados deste estudo irão contribuir para um melhor conhecimento do processo e qualidade da referenciação por parte dos Cuidados de Saúde Primários (CSP), e da qualidade da resposta dada pelos Cuidados de Saúde Secundários no que respeita aos tempos de resposta e à transferência de cuidados após a alta hospitalar. Ao nível dos CSP poderá ainda contribuir para avaliar se existem ou não discrepâncias no processo de referenciação entre diferentes modelos de unidades e servir de ponto de partida para um ciclo de melhoria contínua da qualidade
Multimorbilidade: impacto no exercício da medicina centrada na pessoa e no distress médico em medicina geral e familiar
Authors:   FMUC - Faculdade de Medicina da Universidade de Coimbra, Regatia Rita , Santiago Luiz Miguel ,   FMUC - Faculdade de Medicina da Universidade de Coimbra
Published: March 2023

Introdução: A multimorbilidade (MM) é muito prevalente. A sua gestão origina sobrecarga em medicina geral e familiar (MGF) com implicações negativas na prática da medicina centrada na pessoa (MCP) e baixa os níveis de saúde mental (ansiedade e depressão) nos médicos de MGF, com impacto nos resultados em saúde. A MCP, reconhecendo holísticamente o doente, promove adesão ao tratamento, melhoria das consequências em saúde e bem-estar na saúde mental dos médicos, importante para melhor desempenho profissional. Objetivos: Avaliar se a sobrecarga pela gestão da MM está associada à menor autoperceção da prática de MCP e a sintomas de distress psicológico nos médicos de MGF. Métodos: Estudo observacional, transversal em amostra de conveniência de médicos de MGF aplicando um questionário online com o fator «Gestão da Consulta», do Questionário de Avaliação da Sobrecarga da Gestão da Multimorbilidade em MGF (SoGeMM-MGF), a dimensão «Compreender a pessoa como um todo», do Questionário de Autoperceção do Desempenho da Medicina Centrada na Pessoa em MGF, o Patient Health Questionnaire-4 (PHQ-4) e quatro perguntas de contexto. O estudo decorreu em agosto de 2021. Nas escalas, uma maior pontuação significa melhor estado. Resultados: Amostra de n=151, 72% feminina, 45% com idade inferior a 35 anos. Verificou-se correlação negativa entre a pontuação «Gestão da Consulta» e «Compreender a pessoa como um todo» (ρ=-0,220; p=0,007) e correlação positiva entre a pontuação «Gestão da Consulta» e PHQ-4 (ρ=0,320; p<0,001). Conclusões: Nesta amostra a sobrecarga pela gestão da MM associou-se a menor autoperceção da realização da MCP e a piores níveis e saúde mental nos médicos de MGF.
National newborn screening for sickle cell disease and communication of carrier status
Authors:   CHUSJ, Rocha Diogo Fernandes da , Vilarinho Laura ,   Médico de Família, Louro Pedro ,   Médico de Família
Published: March 2023

Portugal is currently implementing a pilot project to screen for sickle cell disease during national newborn screening. This project started in the region of Lisbon and the Tagus valley where there is a higher frequency of African population. Anticipating the expansion of this screening to the rest of the national territory, a question arises: how to deal with cases of identified sickle cell trait carriers?
Síndroma ARCAPA: o papel do médico de família na gestão de uma doença rara
Authors:   USF do Minho - ACeS Cávado I Braga, Castro Carlos Rocha , Fachado Francisco ,   USF do Minho - ACeS Cávado I Braga
Published: March 2023

Introdução: A síndroma ARCAPA (origem anómala da artéria coronária direita a partir da artéria pulmonar) é uma cardiopatia congénita rara. Pode cursar com enfarte agudo do miocárdio ou morte súbita, embora a maioria dos doentes não apresente sintomas, sendo o diagnóstico realizado acidentalmente. O médico de família (MF) é o profissional que melhor pode compreender a perspetiva do utente face à doença, integrando-a no seu contexto biopsicossocial. Descrição: Sexo masculino, 48 anos. Antecedentes de perturbação da ansiedade generalizada. Praticante regular de exercício físico de alta intensidade. Em fevereiro/2019, por intercorrência febril e suspeita de pneumonia, realizou TC-tórax, que revelou “ectasias vasculares pericárdicas extensas”, tendo sido referenciado à consulta de cardiologia pelo MF. Realizou angioTC, que evidenciou “síndrome ARCAPA”. Encontrava-se assintomático do ponto de vista cardiovascular. Pelo risco de morte súbita foi proposta cirurgia e recomendada a suspensão do exercício físico. A descoberta acidental desta síndroma, numa fase de ausência de sintomas, gerou sentimentos de incompreensão no doente, agudizando a patologia ansiosa. Através de uma abordagem centrada na pessoa, o MF procurou compreender as expectativas, sentimentos e medos do doente, bem como envolver a família na tomada de decisão. O doente, por sua iniciativa, manteve a prática de exercício, afirmando que a suspensão iria contribuir negativamente para a sua saúde mental. Rejeitou também a proposta cirúrgica. Atualmente mantém consultas de seguimento regulares com o MF e cardiologista para vigilância de sintomas. Comentário Para além da sua raridade, o caso descrito reflete a importância da prática de uma medicina centrada na pessoa, sobretudo após o diagnóstico de uma patologia grave, com tamanho impacto na vida do doente. É fulcral que o MF tenha o conhecimento científico necessário para a gestão da doença e que a integre no contexto psicossocial e familiar do utente, aconselhando-o e apoiando-o na partilha das suas decisões.
Diabéticos sem semaglutido: qual o verdadeiro problema?
Authors:   ACeS Lisboa Ocidental e Oeiras, João Sara , Melícia André ,   ACeS Cascais, Lisboa, Leite Raquel Baptista ,   ACeS Cascais, Lisboa
Published: March 2023

Diabéticos sem semaglutido: qual o verdadeiro problema?
Impact of entrepreneurial orientation on business performance: Analysis of small-medium sized corn enterprises
Authors: Christi Areyne , Sukri Urbanus , Widyaningtyas Ester , Budiwaluyo Hari
Published: March 2023

This article aims to examine the impact of entrepreneurial orientation on the performance of small and medium enterprises in the corn business to encourage the improvement of the performance of SMEs in East Java. This study uses an entrepreneurial management science approach, especially for research on the effect of entrepreneurial orientation with dimensions of autonomy, innovation, proactiveness, risk-taking, and competitive aggressiveness on company performance with measurements of financial perspective, market perspective, and quality perspective. This study uses a cross-sectional method approach. The results showed that entrepreneurial orientation affected company performance. Owner involvement in the business can improve business performances.
There is high prevalence of overnutrition among married and cohabiting women in Nigeria: Findings from the 2018 Nigeria Demographic and Health Survey
Authors: Badru Oluwaseun , Adeyemo Alabi Tunde
Published: March 2023

Overweight and obesity are currently an epidemic affecting both developed and developing countries. Sub-Saharan Africa has a double burden of being underweight and obese and has recently been battling an alarming increase in the prevalence of overweight. This study investigates the predictors of overnutrition among married women of reproductive age in Nigeria using the socioecological model (SEM) as a framework, and hypothesized that the Southern region will have higher burden of overnutrition compared to the Northern region.The cross-sectionalstudy design was adopted using the 2018 Nigeria Demographic and Health Survey. A total of 8531 non-pregnant married women met the inclusion criteria. Bivariate logistic regression and hierarchical multilevel logistic regression models were fitted, which were informed by the socioecological model framework.The prevalence of overnutrition was 31%. When all covariates were fitted in a model, being older, being a Christian, having tertiary education, having an older partner with tertiary education, being wealthy, and living in a rural area were predictors of overnutrition at multivariate analysis. The predictive power increases as one moves from a lower to a higher level in the SEM - 24.9%, 25.5%, and 25.7% at the individual, interpersonal, and community/societal levels, respectively. Theprevalence of overnutrition among Nigerian married women is high, especially in the Southern region. Predictors of overweight are at all the SEM levels; however, it is better to consider all the levels when planning public health interventions.
МОДЕЛЬ ФОРМУВАННЯ ГОТОВНОСТІ МАЙБУТНІХ ОФІЦЕРІВ-ПРИКОРДОННИКІВ ДО ЗАСТОСУВАННЯ ІНФОРМАЦІЙНИХ ТЕХНОЛОГІЙ У ПРОФЕСІЙНІЙ ДІЯЛЬНОСТІ
Authors: ДЗЮБА Петро
Published: March 2023

Статтю присвячено дослідженою актуальності формування готовності майбутніх офіцерів-прикордонників застосовувати інформаційні технології у професійній діяльності. Реалії та виклики нашого часу висувають нові вимоги щодо рівня професійних якостей, навичок, вмінь та розвитку майбутніх офіцерів-прикордонників, так як процес підготовки повинен рухатись з розвитком суспільства та у відповідності до сучасних світових стандартів. Особливий акцент необхідно зробити на якості знань із застосуванням інформаційних технологій, що забезпечують формування програмних результатів навчання та відповідають процесу інформатизації освіти. У статті розглядаються елементи освітнього процесу, що впливають на інформаційний розвиток майбутніх офіцерів-прикордонників. Сформовано модель, що базується на окремих логічних, взаємопов’язаних блоках, які є основою процесу формування готовності майбутніх офіцерів-прикордонників до застосування інформаційних технологій у професійній діяльності. Це концептуально-цільовий блок, блок програмних результатів навчання, інноваційно-діяльнісний та аналітичний блок. Окрему увагу приділено формуванню класифікації програмного забезпечення, що супроводжує освітній процес у військовому закладі вищої освіти. Для досягнення високих показників інформаційного розвитку майбутніх офіцерів-прикордонників при викладанні загальновійськових дисциплін впроваджено розділену класифікацію програмного забезпечення, що складається з професійно-активного та спеціалізованого. Кожна складова класифікації програмного забезпечення в процесі навчання надає можливість інформаційного розвитку та забезпечує професійними якостями в процесі інформаційного розвитку особистості. Окремо визначено роль викладача при побудові освітнього процесу із застосуванням інформаційних технологій, що базується на реалізації принципу самоосвіти на основі інформаційних технологій. На цьому етапі доцільно застосовувати найрізноманітніше програмне забезпечення, яке реалізує принцип інформаційної креативності особистості.
ФОРМУВАННЯ КОМПЕТЕНТНОСТІ МАЙБУТНЬОГО ОФІЦЕРА У ВИРІШЕННІ ПРОБЛЕМНИХ ПЕДАГОГІЧНИХ СИТУАЦІЙ
Authors: МОТИКА Сергій
Published: March 2023

У статті обґрунтовано технологію формування компетентності майбутнього офіцера у вирішенні проблемних педагогічних ситуацій. Під проблемними педагогічними ситуаціями розуміються порушення у логіці розвитку військово-педагогічного процесу, зумовлені суперечностями у відносинах учасників цього процесу, неадекватністю вибору педагогічних засобів та відсутністю прогнозу наслідків їхнього застосування. Результати аналізу власного досвіду автора дозволяють вважати, що на становлення професійної компетентності офіцера у вирішенні проблемних педагогічних ситуацій впливають спрямованість на педагогічну діяльність, установка на роботу з особовим складом, інтерес до предмета і потреба у самоосвіті, розвинене професійне мислення, володіння базовими педагогічними категоріями. Ці та інші якості необхідно розглядати у структурі професійної компетентності офіцера у вирішенні проблемних педагогічних ситуацій як одного з напрямків розвитку його професійної готовності. Професійна компетентність офіцера у вирішенні проблемних педагогічних ситуацій є його інтегральною професійно-особистісною характеристикою, що проявляється в його здатності до сприйняття педагогічних колізій як природного стану навчально-виховногопр оцесу та службово-бойової діяльності, що вимагає компетентних дій з аналізу, ідентифікації, розроблення та реалізації плану вирішення проблемної педагогічної ситуації. До складу професійної компетентності майбутнього офіцера у вирішенні проблемних педагогічних ситуацій входять мотиваційна готовність до адекватного прийняття цієї ситуації, володіння методологічними та теоретичними основами аналізу проблемних педагогічних ситуацій, вміння проєктувати та реалізовувати способи вирішення різноманітних проблем у педагогічному процесі. Основним засобом формування професійної компетентності майбутнього офіцера у вирішенні проблемних педагогічних ситуацій є система ситуацій, що містить: прийняття суперечності як проблеми, яка потребує цілеспрямованих дій офіцера щодо педагогічнодоцільного вирішення суперечності; набуття досвіду аналізу та вирішення ситуації за заданою схемою та відомого з практики методу; творчого підходу до виниклої суперечності та пошуку самостійного рішення на основі застосування проектно-дослідницької методології; самовизначення у проблемі, що виникла, моральної оцінки дій учасників ситуації, вироблення та практичної реалізації власного рішення.
КОМУНІКАТИВНА КУЛЬТУРА МАЙБУТНЬОГО КЕРІВНИКА ОРКЕСТРОВОГО КОЛЕКТИВУ: ЗМІСТ І СУТНІСТЬ ПОНЯТТЯ
Authors: ПОТАПЧУК Тетяна , ОНИЩУК Володимир , МІРОШНІЧЕНКО Валентина
Published: March 2023

У статті зазначено, що культура спілкування є складовою культури людини в цілому. Вона, як і будь-яка інша, містить у собі певну суму знань. Подано, що культурі спілкування майбутнього керівника оркестрового колективу притаманна нормативність, яка визначається станом суспільства, його історією, традиціями, національною своєрідністю, загальнолюдськими цінностями. Для досягнення високого рівня професійно-педагогічної комунікативної культури майбутньому керівнику оркестрового колективу необхідно знати індивідуально-психологічні особливості своїх вихованців, адекватно реагувати на їх поведінку і психологічний стан, добирати для кожної людини у відповідній ситуації такий спосіб спілкування, який не вступав би у протиріччя із загальнолюдськими цінностями, мораллю суспільства, гуманністю, і в той же час мав би відповідати індивідуальним особливостям конкретної особистості. З’ясовано, що комунікативна культура майбутнього керівника оркестрового колективу є однією з визначальних властивостей сучасної людини, оскільки займає провідне місце в загальнокультурному і професійному становленні особистості. Авторами встановлено, що комунікативна культура майбутніх керівників оркестрового колективу є складовою їхньої професійної компетентності та забезпечується впорядкованістю знань, норм, цінностей і зразків поведінки, прийнятих в суспільстві та вміння органічно, природно і невимушено реалізувати їх у професійній діяльності. Водночас вона є сукупністю спеціальних комунікативних знань, навичок і умінь, за допомогою яких фахівець запобігає виникненню психологічних ускладнень, долає можливі труднощі, бар’єри та прогнозує результативність міжособистісної та ділової професійної взаємодії.
Outcomes and Complications of Incomplete Spinal Cord Injury in the Thoracolumbar Region
Authors:   Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran AND Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Rehanian Zoheir , Hamzei Arman ,   Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Yousefzadeh-Chabok Shahrokh ,   Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran, Jafari Seifollah ,   Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Emamhadi Mohammdreza ,   Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Behzadnia Hamid ,   Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Keihanian Fatemeh ,   Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran
Published: March 2023

Background and Aim: Improvement of neurological disorders in patients with incomplete spinal cord injury (SCI) remains an important issue worldwide. This study aimed to explore the outcomes and complications of patients with incomplete SCI in the thoracolumbar region within one year after trauma. Methods and Materials/Patients: In this longitudinal prospective study, patients with traumatic incomplete SCI were studied. The demographic and clinical variables including age, sex, site of injury, motor force, sensory disorder, and sphincter dysfunction were recorded on admission and 3, 6, 9, and 12 months after discharge. SPSS software, version 28 was used for data analysis. Results: Out of 120 patients with incomplete SCI, 100 patients were included. The mean age of the participants was 32.39±7.47 years and the mean duration of hospitalization was 14.78±3.81 days. The most common injury site was T12-L1 (43%). Over time, the average motor force of patients increased. The lowest and highest averages were observed during hospitalization and 12 months after discharge, respectively. No significant difference was observed in the paired comparison of motor force at 3, 6, 9, and 12 months after discharge. The frequency of sensory disorders decreased over time. The highest and lowest frequencies belonged to the hospitalization time (81%) and 12 months after discharge (9%). No significant difference was observed between the time intervals of 6, 9, and 12 months, as well as the time of hospitalization and discharge. Over time, the frequency of sphincter dysfunction decreased. Pulmonary infection (12%) and bed sores (9%) were the complications observed during hospitalization. Complications observed 12 months after admission were bed sores (21%) and venous thrombosis (17%). Conclusion: The highest recovery rate of motor force was recorded within the first three months. The frequency of sensory and sphincter disturbances in patients decreased over time with the highest recovery rate during the first six months after the injury.
The Cytotoxic Effect of the Tarragon (Artemisia dracunculus L.) Hydroalcoholic Extract on the HT-29, MKN45, and MCF-7 Cell Lines
Authors:   Medicinal Plants Research Center, Mazandaran University of Medical Sciences, Sari, Iran., Motafeghi Farzaneh , Habibi Emran ,   Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran., Firozjaei Maryam ,   Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran., Eghbali Mohammad ,   Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran., Mortazavi Parham ,   Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran., Salmanmahiny Amirhossein ,   Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran., Shokrzadeh Mohammad ,   Medicinal Plants Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Published: March 2023

Background::Cancer is one of the problems facing societies today and despite new advances in chemotherapy and cancer treatment, there are still many cancers that do not respond to today’s treatments. Tarragon with the scientific name of Artemisia dracunculus L. has various flavonoid and polyphenolic compounds and many therapeutic effects. Objectives: This study aimed to investigate the cytotoxicity of this plant on different categories of cancer cels. Methodes: After collecting the shoots of tarragon and extracting them by the maceration method, the weight of the extract with a yield of 22.25% was 12.9 g. After examining the presence of flavonoids and total phenol, the extract’s antioxidant activity was examined using DPPH and FRAP methods. Finally, MTT tests on three cancer cell lines, MCF-7, HT-29, and MKN45, were done using different concentrations of tarragon extract (100, 200, 500, and 1000 μg/mL). Results: Total flavonoids were detected at 24±1.18 mg of quercetin per gram of extract, and total phenols were detected at 59±2.21 mg of gallic acid per gram of extract. Examining the inhibitory effect of DPPH compared to vitamin C, it was found that the hydroalcoholic extract of tarragon has a 50% inhibitory effect. According to the standard curve, the amount of iron reduced by tarragon hydroalcoholic extract is equal to 405±0.11 μg/ml. The cytotoxic effect of tarragon hydroalcoholic extract on MCF7, MKN45, and HT-29 cell lines was investigated, and their IC50 values were 1065.669, 881.19, and 743.870 μg/mL, respectively. The A. dracunculus L extract inhibits the growth of cancer cells in various cell lines.
Comparison of Biochemical and Hematological Parameters Among COVID-19 Patients With and Without Vaccination in a Tertiary Care Hospital: A Retrospective
Authors:   KAHER’s JGMM Medical College, Hubblli-580028, Karnataka, India., Petimani Mahalaxmi S , Adake Prabhakar ,   KAHER’s JGMM Medical College, Hubblli-580028, Karnataka, India., H Pavithra ,   Department of Community Medicine, Yenepoya Medical College, Yenepoya (Deemed to be University), Karnataka, India., Kaladharan Drisya ,   Department of Biochemistry, Yenepoya Medical College, Yenepoya (Deemed to be University), Karnataka, India.
Published: March 2023

Background: The availability of the COVID-19 vaccine during the pandemic has changed the disease course in the entire world. The current study aimed to compare various hematological parameters among COVID-19 patients with and without vaccination. Methods: The present retrospective study included 26 vaccinated and 26 non-vaccinated COVID-19 patients. Various clinical and biochemical parameters of RT-PCR-positive patients were collected. The values are expressed in Mean±SD or median values IQR. Mann-Whitney U test was used for comparison between the groups. Results: Among the vaccinated individuals, 17 cases (65.4%) were asymptomatic, one patient (3.8%) had moderate, eight cases (30.8%) had mild COVID-19 infection and all 26 patients were completely recovered. Among non-vaccinated COVID-19 patients, 25 cases (96.2%) had severe, one case (3.8%) had moderate COVID-19, and 16 patients (61.5%) recovered but ten cases succumbed to COVID-19. There were statistically significant differences in SpO2, total leucocyte count, and differential counts of neutrophils, lymphocytes, eosinophils, monocytes, and basophils between vaccinated and non-vaccinated patients (P<0.001). The neutrophil/lymphocyte ratio was found to be at a higher level (P<0.01) among non-vaccinated patients [10.9(4.28-23.63)] compared to vaccinated [1.55(1.09-2.28)]. The blood urea, total and direct bilirubin, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and inflammatory markers, like C-reactive protein (CRP), D-dimer, ferritin, and lactate dehydrogenase (LDH) were highly elevated in non-vaccinated patients (P<0.001). Moreover, lower values of total protein, serum albumin, and albumin and globulin (A/G) ratio were noted in the non-vaccinated compared to vaccinated individuals (P<0.001). Conclusion: Vaccinated patients had milder disease with fewer derangements of hematological parameters compared to non-vaccinated patients. It can be concluded that vaccine has played a vital role during the COVID-19 pandemic in reducing mortality.
Bioassay-guided Antidiabetic Study of Chromatographic Fractions of Boswellia Dalzielii Hutch. Leaf Extract
Authors:   Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, PMB, Maiduguri, Borno State, Nigeria, Yakubu James , Amos Charity ,   Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Borno State, Nigeria, Ndai Medugu Asinamai ,   Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Florida, USA., Dawa Samuel Ibrahim ,   Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, Maiduguri,Nigeria., Abdulrahman Fanna Inna ,   Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, PMB, Maiduguri, Borno State, Nigeria, Adebola Sodipo Olufunke ,   Department of Clinical Pharmacology and Therapeutics, College of Medical Science, University of Maiduguri, Maiduguri, Borno State, Nigeria, Wampana Bitrus ,   Department of Pharmacology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria.
Published: March 2023

Background: Boswellia dalzielli Hutch. (Burseraceae) is a medicinal plant, which is used locally by the local dwellers for the management and treatment of microbial-related diseases, neurological conditions, stomach spasms, diabetes, etc. Objectives: This study aimed at isolating a phytochemical of anti-diabetic potentials from the leaf of Boswellia dalzielii in alloxan-induced diabetic rats. Methods: The n-butanol fraction of the leaf of B. dalzielii was fractionated using column chromatography. Fractions obtained were screened phytochemically and by antidiabetic study. Results: Encoded column fraction B4 (150 mg/kg) produced a maximum reduction (72.45%) in fasting blood glucose (FBG) of animals after 7 hours, which was significantly (P<0.05) different from the controls (alloxan-induced diabetic rats) and was better than glibenclamide (52.67%). The re-column fractions obtained from fraction B4 were pooled based on similar Rf values and encoded B41-B48, and subjected to further antidiabetic evaluation on alloxan-induced mice. Eight sub-fraction with doses of 50 mg/kg each were administered to all the groups. Fraction B44 had the highest reduction of FBG by 65.63%, whose effect was significantly higher than the non-treated diabetic mice (negative control) and glibenclamide (52.68%) at 2.0 mg. Further purification of sub-fraction B44 with Sephadex LH-20 yielded encoded fractions A, B, and C. Isolate C showed the highest inhibition of glycemia (22.85%) when the dose of 10 mg/kg was administered (p.o). Conclusion: The antidiabetic effect of the plant in laboratory animals (rats and mice) may be due to the presence of the isolated phenolic compounds.
Effects of Dioxin on DNA Damage in the Testes of Adult Male Mice
Authors: Mohammadi Shabnam , Jalilvand Narjes ,   Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Esfandiari Fatemeh ,   Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Attari Seyed Saleh ,   Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Published: March 2023

Background: Given the importance of environmental factors and the impact of environmental pollutants, such as dioxins, on organ systems, especially the reproductive system, it is necessary to study these issues and the mechanisms of their effects. Objectives: This study aimed to investigate the effects of different doses of dioxins on DNA damage in the testes of adult male mice. Methods: In this experimental study, 32 male Naval Medical Research Institute (NMRI) rats were randomly divided into four groups: The control group received normal saline, and the dioxin groups were treated with different doses (0.1, 0.5, and 1 µg/kg) for two weeks. Apoptosis in the testes was then examined using a TUNEL assay kit. Results: The mean number of TUNEL-positive spermatogonia cells was 5.91±5.28 in the dioxin group 1, 7.20±10.03 in the dioxin group 2, and 8.73±4.63 in the dioxin group 3, which was higher than that in the control group (0.16±0.40; P=0.073, P=0.034, and P=0.007, respectively). The mean number of TUNEL-positive spermatocyte cells was 5.16±1.99 in the dioxin group 1, 2.50±4.62 in the dioxin group 2, and 3.33±2.94 in the dioxin group 3, which was higher than that in the control group (P=0.034, P=0.14, and P=0.037, respectively). The mean number of TUNEL-positive spermatocyte cells in the dioxin group 1 was significantly higher than that in the dioxin group 2 (2.50±4.62, P=0.047). The average number of TUNEL-positive spermatid cells was 11.58±6.90 in the dioxin group 1, 11.10±12.19 in the dioxin group 2, and 10.20±7.32 in the 3-dioxin group, which was higher than that in the control group (0.16±0.40; P=0.008, P=0.014, and P=0.015, respectively). Conclusion: The results of the present study showed that dioxin caused dose-dependent apoptosis in the testes.
Specific Features of Designing Microwave Photonic Receiving and Transmitting Channels of Onboard Systems for Communication, Radar and Radio Monitoring
Authors: Unchenko I. V. , Emelyanov A. A.
Published: March 2023

Introduction. Designers of modern on-board systems for communication, radar, and radio monitoring face the problem of improving their qualitative characteristics, including the operating frequency, instantaneous bandwidth, receiver sensitivity, and electromagnetic compatibility. In addition, the dimensions, weight, and power of such systems, as well their cost, should be minimized. However, the current semiconductor microwave electronics has reached its limits in terms of frequency and dynamic characteristics. A possible solution consists in the implementation of microwave photonic transmission lines in the design of on-board systems for communication, radar, and radio monitoring on the basis of modulation of laser radiation by means of electro-absorption.

Aim. To study the transfer characteristics and noise figure of a microwave photonic transmission line realized based on the modulation of laser radiation by means of electro-absorption. To compare the results of theoretical calculations and experimental investigations.

Materials and methods. The research methodology involved external modulation using an electro-absorption modulator (EAM), mathematical representation of the transmission coefficient, as well as comparison of the theoretical and practical results.

Results. Theoretical values of the transmission coefficient and noise figure for a microwave photonic transmission line based on the external modulation method using an EAM were obtained. Experimental values of the transmission coefficient and noise figure for a microwave photonic line in the frequency range from 100 MHz to 16 GHz were presented. The obtained data were compared with those of the nearest mass-produced products of foreign production and those presented in domestic publications on microwave photonic signal transmission lines.

Conclusion. The use of an EAM, whose main advantage consists in the possibility of integration with a laser emitter, allowed the authors to design and manufacture a small-sized industrial prototype of a radio-photonic transceiver, capable of transmitting a radio signal over tens of kilometers in the frequency range from 100 MHz to 12 GHz with a transmission coefficient of at least −3 dB and a noise figure no more than 36 dB at the upper operating frequency. At the same time, the closest analogue manufactured by Emcore with similar dimensions has a transmission coefficient of −30 dB and uses direct modulation of laser radiation as a transmission method, which significantly reduces the transmission range of the microwave signal.
Formation of Probing Signals of Piezoelectric Transducers for Ultrasonic Testing
Authors: Konovalov S. I. , Yuldashev Z. M.
Published: March 2023

Introduction. Reducing the duration of the probing pulse at the output of a multilayer radiator is an urgent task of acoustic non-destructive testing. This not only improves the resolution of the system and the accuracy of determining the coordinates of defects, but also reduces the length of the dead zone. The most versatile method for achieving short signal duration is mechanical damping. The use of RL circuits connected to the electrical side of a piezoelectric transducer (PET) for this purpose has been studied to a lesser extent. Of interest is a comparative study of the potential possibilities of the two indicated methods for obtaining a short signal.

Aim. To carry out a comparative study of two options for reducing the duration of the probing signal in order to establish their preferential use in the practice of ultrasonic testing.

Materials and methods. To determine the boundaries of the preferred application of one of the methods in comparison with the other, a mathematical apparatus is used based on the use of integral calculus, as well as numerical calculation methods. When constructing a mathematical model of piezoelectric transducers operating in a pulsed mode, the method of analog circuits is used in combination with the spectral method based on Fourier transforms. Numerical calculations were performed in the MathCad environment.

Results. It was established that the use of an electrical corrective circuit with optimal parameters makes it possible, across a wide range of changes in the values of the specific acoustic resistance of the protector, to achieve a shorter duration of probing signals at the output of the probe than in the case of using a damped probe with values of the specific acoustic resistance of the damper zд latitude 10⋅106 Pa⋅s/m. At zд >10⋅106 Pa⋅s/m, preference should be given to mechanical damping of the piezoelectric element. It was found that the amplitude of the signals at the output of the PET with a corrective circuit connected thereto exceeds the amplitude of the signal when the piezoelectric element is damped.

Conclusion. The results obtained allow an a-priori evaluation and comparison of PET capabilities using two methods for creating a short probing signal, as well as a justified selection of materials for creating a protector across a wide range of specific acoustic resistances. The correctly selected parameters of the structural elements of the probe makes it possible to improve the resolution of radiation-reception systems, reduce the length of the dead zone, and increase the accuracy of determining the coordinates of defects. This ultimately improves the quality of acoustic testing of materials and products.
Frequency Response Extension of a Pulsed Magnetic Field Meter Based on an RL Integrator
Authors: Romantsov V. N. , Romantsov S. V. , Romantsova N. V.
Published: March 2023

Introduction. Measurements of the amplitude-time characteristics of pulsed magnetic fields are required in various research and technology areas. Such measurements are carried out during pulsed magnetic field immunity testing, with the magnetic field pulse rise time being hundreds of ns, and the pulse duration to its half initial value (halfdroop) being hundreds of µs.

Aim. To develop a meter of magnetic field strength with a linear conversion characteristic for measuring the pulse rise time, the pulse duration to its half-droop, and the peak value of the pulsed magnetic field strength.

Materials and methods. Among several available methods for measuring pulsed magnetic field parameters, the induction method was selected. To obtain a signal proportional to the pulsed magnetic field strength, a signal from the induction transducer is integrated using a self-integrating induction transducer (RL integration) or by using an external RC integrator. The former method shows good results when measuring signals with a duration of hundreds of ns; however, this method is inefficient when measuring the parameters of longer-duration pulses. The latter method is used to determine the parameters of signals with a duration of hundreds of µs and ms; however, this method gives a large error when measuring the parameters of signals with a duration of hundreds of ns and less. The consecutive use of the two integration methods leads to an additional error in the measurement of the pulse duration to its half-drop.

Results. A setup for determining the required magnetic field pulse parameters using a pulse magnetic field meter based on an RL integrator was developed. The relative measurement errors comprised 10, 10, and 9 %, respectively. The developed setup eliminates the error caused by losses in the active resistance of an induction transducer, thus enabling the pulse duration to its half-droop to be measured without additional errors under the pulse rise time of hundreds of ns and the pulse droop time of hundreds of µs.

Conclusion. The development of a functional converter made it possible to extend the frequency response of a pulsed magnetic field meter based on an RL integrator to the low-frequency region.
Pengaruh Tax Avoidance, Firm Size Terhadap Earnings Management Dengan Financial Performance Sebagai Pemoderasi
Authors: Arianti Baiq Fitri
Published: March 2023

The purpose of research is to empirically prove the effect of tax avoidance and firm size as independent variables, on earnings management as the dependent variable. The study also examines the role of the financial performance in moderating the relationship between these variables. The population in this study are mining sector companies listed on the Indonesia Stock Exchange for the period 2016 to 2020 totaling 193 companies. The sample in this study amounted to 28 companies with purposive sampling method, the data that were successfully processed were 140 observations. The type of research used is descriptive quantitative research. The data analysis method uses panel data regression with the help of E-views 10 software. The results showed that tax avoidance has a positive and insignificant effect on earnings management, while firm size has a negative and significant effect on earnings management, financial performance variables cannot moderate the influence of tax avoidance and financial performance variables can moderate the influence of firm size on earnings management.
Pengaruh Pertumbuhan Penjualan, Leverage Operasi, Dan Struktur Aktiva Terhadap Struktur Modal
Authors: Novianti Lely , Budyastuti Triyani
Published: March 2023

The purpose of the research is to analyze the influence sales growth, operating leverage, and asset tangibility of the capital structur. The method used in this study is purposive sampling. The population in this study is the mining sector companies listed on the Stock Exchange as many as 47 companies. The number of samples studied in this study was as much as 132 samples. The collection of data used in this study of secondary data came from the 33 financial statements of the mining company in the period 2017-2020. Analysis of data from this study uses multiple linear regression. Based on the results of the study concluded that sales growth and operating leverage has no influence on the capital structure, while the asset tangibility has influence on the capital structure.
Kajian Pelaksanaan Pendampingan Serta Pemeriksaan Pengelolaan Keuangan SMA/SMK Negeri Oleh Auditor Inspektorat Daerah Guna Meminimalisir Penyimpangan Pengelolaan Keuangan
Authors: Pakasi Novrabella Clarashinta
Published: March 2023

The purpose of research to find out the implementation of mentoring and financial management audits for SMA/SMK Negeri in North Sulawesi Province by regional inspectorate auditors in order to minimize financial management irregularities. This research was conducted at the Provincial Government of North Sulawesi. The data analysis techniques are data reduction, data display and conclusion drawing/verification which are carried out interactively and take place continuously until complete, so that the data reaches saturation. The results of this study indicate that financial management assistance for SMA/SMK by the Regional Inspectorate auditor is sufficient to minimize financial management irregularities. With the assistance of the regional inspectorate auditor, the school gets additional knowledge that can be used in the implementation of school financial management. 2) Examination of SMA/SMK Financial Management by the Regional Inspectorate auditor is sufficient to minimize financial management irregularities. With the examination of SMA/SMK financial management from the regional Inspectorate auditor, the school gets suggestions for improvement that can be used to correct mistakes.
Tingkat Ketergantungan Keuangan Daerah
Authors: Abdullah Julie , Hasan Wahyudin
Published: March 2023

The purpose of writing this article is to determine the level of regional financial dependence in the North Bolaang Mongondow Regency using the method of financial ratio analysis.  The results showed that over 5 years the government of North Bolaang Mongondow Regency relied heavily on transfer funds from external parties to finance regional expenditures with an average percentage of financial dependence of 93.29 percent.  This high percentage rate shows that the contribution of local original income to the total regional income of the North Bolaang Mongondow Regency is still minimal.