bluuebunny/crossref_metadata_2025 huggingface dataset:
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway
Authors: Xiong Feng , Shen Kai , Long Di , Zhou Suqing , Ruan Pinglang , Xin Yue , Peng Weijun , Yang Ming , Wu Haijing , Lu Qianjin
Published: September 2024

Systemic lupus erythematosus (SLE) is an autoimmune disorder that commonly affects the skin, kidneys, joints, and various other systemic tissues, with its development intricately linked to the process of immunosenescence. Quercetin (QC), a phytochemical that occurs naturally, demonstrates many different biological capabilities, such as antibacterial, antioxidant, and anti-inflammatory activities. Our investigation found that QC effectively reduced kidney damage and relieved lymph node swelling (mLNs) in MRL/lpr lupus mice. Moreover, QC has been found to decrease the number of senescent follicular helper T (Tfh) cells, a pivotal kind of T cells that contribute to the progression of SLE. In vitro, QC exhibited the capacity to modulate mRNA expression levels, with the downregulation of IL-6, IL21-AS1, IL-27, BCL6, and BCL2L12, and the upregulation of FOXP1 and BIM. This modulation resulted in the suppression of Tfh cells differentiation and the enhancement of apoptosis in senescent CD4+ T cells. In addition, the HuProtTM Human Proteome Microarray reverled that QC can directly bind to BCL-2 protein and therefore promote the apoptosis of senescent CD4+ T cell. As a result, our investigative elucidate the potent inhibitory action of QC on the ontogeny of Tfh cells, along with its capacity to abrogate the immunosenescent phenotype. This positions QC as a promising therapeutic strategy for treating SLE
A Generative Approach to Generalize Deep Learning Models for Pavement Distress Segmentation
Authors: Prajapati Abhishek Kumar , Guler Ilgin
Published: September 2024

Maintaining safe and reliable roadway infrastructure is a critical challenge that demands constant monitoring and analysis of surface level pavement distresses. Typically, this maintenance involves identifying and quantifying various forms of road damage, such as cracks and potholes, which are indicative of the pavement's overall health and safety. Recently, deep learning (DL) based automated methods have been recognized as the state-of-art for pavement distress analysis. These methods streamline the maintenance process through a two-step procedure: initially localizing areas of distress on the pavement (i.e., through object detection models) and subsequently performing pixel-level segmentation to quantify the severity of the damage (i.e., through an image segmentation model). However, the effectiveness of DL models is significantly hampered by feature-level distribution shift, a common problem where there is significant difference between training data and real-world data in terms of features like brightness, contrast, texture among other statistical features. This issue affects DL model's generalization ability, limiting its accuracy on new or unseen data. This paper introduces an innovative and cost-effective approach to enhance model generalization in the context of pavement distress segmentation. The proposed solution centers around an unsupervised generative data augmentation strategy that transforms features of new or unseen data to align closely with the training dataset before performing distress segmentation. The framework's effectiveness in improving pavement distress segmentation ability, is demonstrated through comparative analysis against traditional methods under varying distribution shift scenarios. Results indicate a significant improvement in segmentation accuracy, highlighting the potential of generative data augmentation strategy to address distribution shift challenges. This paves the way for future advancements in pavement distress analysis and model generalization.
Emotional Self-Regulation and Sociodemographic Factors on Subjective Well- being of Chilean adolescents
Authors: Fuentealba-Urra Sergio , Céspedes-Carreno Cristian , Rubio Andrés , Oyanedel Juan Carlos , Martínez-Líbano Jonathan , Leigh-González Camila , Arellano-Correa Sandra , Urrutia-Díaz Víctor , Val-Martín Pablo , Fuentealba-Martín Cristian
Published: September 2024

The relationship between emotional regulation and the perception of well-being is now well recognized. However, the influence of short-term emotional regulation strategies, together with sociodemographic factors, on subjective well-being has been partially examined, especially in adolescents with socioeconomic vulnerability conditions. The aim of this article is to analyze the influence of emotional regulation and sociodemographic factors on subjective well-being in adolescent students.
This cross-sectional study considered a sample of 917 adolescents from 10 to 19 years of age, students of primary and secondary Publics Schools in the eighth regions of Chile. Emotional regulation and subjective well-being were measured using self-report questionnaires. Socioeconomic vulnerability was established from the school vulnerability index (SVI) of each student's school.
Multiple regression analysis showed that the level of emotional regulation present in the young people together with gender, age and level of vulnerability were significantly associated with the adolescents' perception of well-being. In this sense, a high level of emotional regulation together with male gender predicted higher well-being scores. On the other hand, female gender and a "high" level of school vulnerability were associated with lower levels of perceived well-being in adolescents.
This study highlights the importance of considering emotional regulation as a relevant factor on subjective well-being in adolescents, particularly in adolescents with conditions of school vulnerability. This aspect together with factors such as gender and age should be considered in the generation of programs and public policies to improve well-being in adolescents.
Effect of social support on the subjective well-being among Chinese college athletes: a chain mediation model
Authors: Tan Shilin , Yao Jiawen , Hu Wenyan
Published: September 2024

College athletes in higher education experience unique challenges due to dual pressures from their academic and athletic commitments, which may negatively affect their mental well-being. Social support is acknowledged as a protective factor that contributes to the mental well-being of college athletes. However, the mechanisms mediating this relationship remain largely unexplored. The Person-Environment (P-E) Fit Theory and Basic Psychological Needs Theory (BPNT) provide theoretical insights into the mediating mechanisms that explain how contextual factors influence individual well-being. This study examines the independent and sequential mediating roles of P-E fit and basic needs satisfaction in the relationship between social support and subjective well-being among college athletes. Data were collected through cluster random sampling from 822 college athletes across Jiangsu and Yunnan Provinces, China, averaging 20.33 years of age, with 70.44% being male. Structural equation modeling was adopted to examine the hypothetical model. The results indicate that social support directly enhances subjective well-being. Both P-E fit and needs satisfaction partially mediate this relationship, with adjustments for demographic and sports-related variables. The results showed that college athletes’ subjective well-being was interpreted as 47.2% by the overall mode. This study advances the understanding of how social support impacts college athletes’ well-being through specific mechanisms and suggests methods to strengthen support systems in higher education.
Design, Simulation and Fabrication Analysis of Rectangular Patch Antennas for Enhanced Performance
Authors: N Rashmi , S Lakshmisagar H
Published: September 2024

This research delves deeply into a comprehensive exploration of the utilization of the finite element method (FEM) for the analysis of microstrip antenna configurations such as rectangular patch. An experimental fabrication of the antenna is carried out to evaluate the efficacy of FEM by examining parameters like gain, bandwidth, VSWR, return loss S11, directivity, and radiation patterns at a frequency of 3GHz. A Performance comparison between the existing and proposed microstrip antennas is presented .Notably, a significant correlation is noted between the recommended antenna characteristics and previous research conducted at the same frequency. Furthermore, our compact antenna design demonstrates its suitability for 5G wireless systems. Regardless of their miniature size, these antennas display exceptional radiation efficiency, with a bandwidth of about 204MHz, and a directivity of around 4.004 dB.
Influence of Pusa Hydrogel and Foliar Nutrient Spray on Rainfed Soybean in Northwest Himalayan Region
Authors: Bhat Shabir Ahmad , Bahar Fayaz Ahmed , Raja Waseem , Chesti Majeed Ul Hassan , Sheikh Tahir Ahmad , Wani Faheem , Rasool Khalid , Habib Raihana , qayoom Sameera , Bhat Tauseef , Jan Bisma , Nazir Bisma , Gulzar Marifa
Published: September 2024

Soybean is an important oilseed crop, cultivated all over the world. In India, it is cultivated on an area of 12.2 million hectares with a production of 13.5 million tons and productivity of 1.5 tons ha-1 (Directorate of Economics and Statistics, 2022). The national productivity of soybean (1.5 ton ha-1) is quite lower followed the world average (5.56 ton ha-1). (FOASTAT, 2022). One of the reasons for low productivity in soybean cultivation can also be attributed to insufficient soil moisture and erratic distribution of rainfall being experienced on account of global climate change. The other reason for soybean yield losses is an inadequate supply of nutrients . To provide a solution to the problems of the present dryland Agriculture, water-saving materials need to be used besides being the assured supply of nutrients. Thus, the present study was undertaken to investigate combined effect of Pusa hydrogel (an indigenous product that was created to increase crop productivity per unit of available nutrients and water, especially in agriculture under moisture stress) and foliar nutrient sprays to increase productivity and conserve available soil moisture. Application of Pusa hydrogel level H3 5.0 kg ha-1 and F4 Thiourea 500ppm recorded significantly higher plant height, dry matter accumulation, number of leaves , number of branches , leaf area index (LAI) while with respect to yield and yield attributing characters Pusa hydrogel H3 5.0 kg ha-1 and F5 Vermiwash (1:10) ratio resulted significantly higher seed yield of soybean
Hepatitis B Antibody Trajectories in Medical School Students: An Empirical Comparison of Longitudinal Clustering Methods
Authors: Lu Xinyue , Xu Xingyan , Yang Le , Zheng Liuyan , Guo Jianhui , Zhu Li , Zhou Jungu , Zhang Zhiyu , Wu Siying , Li Huangyuan
Published: September 2024

Introduction:
The trajectory of antibody levels following hepatitis B vaccination (HepB) at various dosages has rarely been explored. This study compares three distinct longitudinal clustering methods to analyse the development of antibodies following HepB to evaluate antibody titres before vaccination, after the first dose, and after the second dose to assess the effectiveness of these clustering techniques.
Methods
The hepatitis B antibody (HBsAb) titres of 312 freshmen at Fujian Medical University in China were analysed to identify clusters in which the antibody level changed over time. Antibody levels were measured at three time points: prevaccination, postfirst dose, and postsecond dose. K-means cluster analysis and latent growth mixture modelling (LGMM) methods were conducted via the R packages kml and lcmm, respectively. Additionally, group-based trajectory modelling (GBTM) was performed with the Stata plugin traj.
Results
K-means clustering and latent growth mixture modelling (LGMM) classified antibody development trajectories into three distinct clusters: high, medium, and low antibody levels. In contrast, the group-based trajectory modelling (GBTM) method identified only two clusters, corresponding to high and low antibody levels. The K-means and LGMM methods demonstrated the highest similarity in cluster shapes and provided a relatively better fit to the data. Conversely, the GBTM method produced more distinct trajectory shapes but did not align as well with the observed data.
Conclusion
After the trajectory analysis packages kml, lcmm, and traj were compared via HBsAb data, it was determined that the kml package offered the most appropriate clustering for antibody data. This finding may help inform strategies to optimize herd immunization.
3D-Printed Skull Model for Enhancing Training in External Ventricular Drainage within Medical Education
Authors: Scheidt Katharina , Kropla Fabian , Winkler Dirk , Möbius Robert , Vychopen Martin , Wach Johannes , Güresir Erdem , Grunert Ronny
Published: September 2024

Background: The importance of reducing error rates in invasive procedures has led to the development of teaching phantoms. In collaboration with surgeons and engineers at the University Hospital of Leipzig, a new 3D-printed simulation model for external ventricular drainage was created. This model includes system-relevant components such as the ventricular system, the surrounding brain tissue and the skull bone to be trephined.
Methods: The data required for analysis were extracted from medical images. The phantom consists of three components: the ventricular system, the brain mass, and the skull bone. The bone component was fabricated via 3D printing using a realistic hard polyamide, PA12. The ventricular system was also 3D printed as a hollow structure using a flexible material, Elastic Resin 50A from Formlabs. The brain tissue was modeled via a cast gelatin mold. The cerebrospinal fluid was a water solution.
Results: The system’s initial tests successfully simulated cerebrospinal fluid flow through the tube into the ventricular system. The skull can be trepanned. Additional materials are required at the drilling sites because of chip formation. A more pointed cannula than usual can puncture the ventricular system. With a concentration of 30 g/l, gelatin is a realistic imitation of brain tissue.
Conclusion: All essential components of the skull, brain and ventricle exhibit a degree of realism that has never been achieved before. In terms of its design and reproducibility, the model is exceptionally well suited for training and consolidating methods and procedures as part of a realistic training program for the placement of external ventricular drainage.
An open-source platform for 3D transcranial Ultrasound Localization Microscopy in awake mice
Authors: Chabouh Georges , Denis Louise , Abioui-Mourgues Myriam , Deloges Jean-Baptiste , Battaglia Jacques , Chavignon Arthur , Heiles Baptiste , Pradier Basile , Bodard Sylvain , Vivien Denis , Orset Cyrille , Couture Olivier
Published: September 2024

We present an open-source code for 3D super-resolution ultrasound imaging. Open-3DULM was applied to transcranial imaging in habituated awake mice. Comparative analysis reveals that isoflurane anesthesia induces significant vasodilation and higher cerebral blood flow compared to the awake state. This method could serve as a reference for developing new types of 3D vascular quantifications, particularly emphasizing the importance of awake and 3D imaging for accurate cerebral blood flow measurement in neuroscience research.
Sedimentary organic carbon burial in marine oxic sediments modulated by anticyclonic eddy
Authors: Bao Rui , Xu Gang , Duan Xiaoyong , Che Yangli , Liu Tongya , Jing Zhiyou , Wan Shiming , Chen Bin , Liu Jian , Liu J. Paul , Yin Ping
Published: September 2024

Anticyclonic eddies (AEs) are a common feature of ocean circulation and play a significant role in influencing the rates of carbon fixation and export. However, the mechanism underlying organic carbon (OC) export and sedimentation modulated by AEs are poorly deciphered. Here, we utilized in-situ observations of dissolved oxygen, chlorophyll, pH, and turbidity in the water column and experimental analyses of molecular biomarkers, OC, and iron trioxide in sediments from the East China Sea, to unravel the processes driving OC sedimentation modulated by AE. Our findings reveal that a significant amount of OC is preserved in oxic sediments, influenced by the presence of an anticyclonic eddy. We suggest that the eddy promotes the accumulation of OC along its periphery, and transports OC downward under the pycnocline. The combination of OC with iron trioxide, facilitated by oxidation, impedes the mineralization of OC in sediments. The accumulation of OC in oxic sediment, modulated by anticyclonic eddies, has significant implications for OC burial in mid-latitude oceans on millennial timescales.
The Relationship Between Sleep Deprivation, Cognitive Function, and Academic Performance among Medical Students: A Cross-sectional Study
Authors: Basharat Ayesha , Abbas Ayesha , Javed Ayesha , Tabba Khush , Ashraf Danish Ali , Fatima Hurmat
Published: September 2024

Objective: To analyze the intensity of sleep deprivation among medical students, understand its effects on cognitive function, and investigate any relationships it may have with academic achievement.
Methods:
A quantitative cross-sectional study was conducted at various medical colleges in Pakistan over 4 months. The sample size of 351 was calculated via OpenEpi software. Data were collected online via a self-generated questionnaire using convenience sampling. The internal consistency of the questionnaire was confirmed with Cronbach’s alpha after a pilot study on 20% of the sample. SPSS 26 was used to analyze the relationships among sleep deprivation, cognitive function, and academic performance using via chi-square test, with significance set at p<0.05.
Results:
Among the 351 medical students, 63.5% reported that more sleep could improve academic outcomes, whereas 8.3% reported poor performance. Over 20% experienced cognitive issues such as forgetfulness, and more than 35% had not experienced major sleep disturbances in the past month. Furthermore, our study revealed weak negative associations between sleep deprivation and both cognitive function and academic performance, with no significant correlation between cognitive function and academic performance.
Conclusion:
Our study revealed weak negative correlations between sleep deprivation and both cognitive function and academic performance, suggesting that poor sleep is only marginally associated with increased cognitive failure and lower self-reported performance. Additionally, no significant link was found between cognitive function and academic performance, indicating that cognitive failure does not have a strong effect on perceived academic success.
Multinacionales mineras en Colombia: extractivismo y conflicto armado en Cerro Matoso, 2000-2013
Authors: Moreno Montenegro Vanessa
Published: September 2024

Este artículo tiene como objetivo principal evidenciar algunos de los impactos que causa la mina de Cerro Matoso y su principal operador BHP Billiton sobre las poblaciones de Montelíbano, Puerto Libertador y San José de Uré, ubicadas en la zona de influencia de la mina, además de mostrar su relación e impactos en el conflicto armado colombiano. Se recurre a la lectura de postulados teóricos que ayudan a la comprensión de la problemática que se aborda en este trabajo.
The intertwining of democracy and economic development. A brief insight for Colombia
Authors: Caicedo Sarralde David
Published: September 2024

The following article will attempt to provide an insight about the relationship between economic development and the democracy of a country. A brief State of the Art revision has been constructed in order to propose a theoretical underpinning for the discussion. In addition, this article includes an interview with Professor Matthew Carnes S.J., in order to enrich the discussion arguments.
His answers make a positive contribution to the debate by displaying alternatives that address the issues of our current political system. During this article, several frameworks will be presented to establish the interconnections between the economic system and the performance of democracy, opening up the door for several authors such as Seymour Martin Lipset, James Robinson, Adam Przeworski, George Akerloff, Robert Shiller, Inglehart, Collier and others, which will be applied to the Colombian case.
Editorial
Authors: Perilla Granados Juan Sebastián
Published: September 2024

El contexto jurídico ha tendido a ser acompañado a través de la historia de un alcance político, pues las normas de rango legal resul- tan en muchas ocasiones como consecuencia de intereses y necesida- des de quienes ostentan el poder para crear el derecho. Esto lleva a que las normas escritas contengan información extra-textual que no necesariamente responden al interés general; quien hace la ley puede beneficiarse de ella en las proporciones hasta donde se le permita. Y aunque se trata de un fenómeno recurrente, la tarea de muchos teó- ricos del derecho ha consistido en matizar esta realidad para dotar al derecho de una aspiración de pureza fundada en legitimaciones que se presentan como lejanas a la voluntad humana. Lo curioso del asunto es que estas escuelas del derecho, generalmente gestadas en el contexto europeo, han guiado en gran medida la formación de los operadores jurídicos desde las Facultades de Derecho y en la práctica profesional misma.
Sustainability Reporting and Corporate Performance: The Moderating Role of Corporate Internationalization
Authors: Yau Josephine Tan-Hwang , Yu Magdalene Sze-Ee , Amidjaya Prihatnolo Gandhi , Liwan Audrey , Kueh Jerome Swee-Hui , Hamdan Rosita
Published: September 2024

This study aims to investigate the relationship between sustainability reporting and corporate performance moderated by the internationalization level of the firms. The sample for this empirical study is collected from the Financial Times Stock Exchange (FTSE)100 firms listed on Bursa Malaysia for a period of nine years from 2011 to 2019. We examine the sustainability reporting based on the Global Reporting Initiative (GRI) standard with the G4 guideline, in which a content analysis method has been employed to obtain the Sustainability Reporting Index (SRI). The moderating variable for this study is the internationalization level, which is proxied by foreign sales generated. The findings demonstrate that sustainability reporting disclosure has no effect on corporate performance. However, internationalization improves corporate performance but serves no moderation role in the relationship between sustainability reporting and corporate performance. We conclude that there is no evidence to substantiate the claim that companies that disclose more in their sustainability reporting perform better, and this may be because Malaysian corporations are still new to non-financial reporting. We believe that although sustainability reporting is costly, sustainability reporting is able to enhance the reputation of firms in the international market. Sequentially, a highly internationalized firm with more sustainability reporting disclosures may bring wealth to the company in the long run.
D-B Mus.ms. Bach P 803, Georg Simon Löhlein, and Surroundings. Part I
Authors:   St. Petersburg State University, Panov Alexei A. , Rosanoff Ivan V. ,   St. Petersburg State University,   Saint Petersburg Rimsky-Korsakov State Conservatory
Published: September 2024

One of the most valuable handwritten folio D-B Mus.ms. Bach P 803, stored in the Staatsbibliothek in Berlin, contains twenty-six layers, which are bound together. It is often associated with the name of Johann Ludwig Krebs, which for a long time gave the impression that the handwritten texts were also done by Krebs. The manuscript was indeed for a long time in Krebs’ house, and J. L. along with his father J. T. Krebs and J. G. Walther, as well as other lesser-known musicians, was one of the copyists. Of the twenty-six attachments, only the second (p. 9–23; further: P 803-II) contained a verbal text and tables with an interpretation of ornaments. It has not been possible to determine who was the copyist of P 803-II to date, and the concept of “anonymous copyist” has become anchored. In 1933, L. Landshoff turned to the tables with the performance of ornaments in P 803-II in connection with the interpretation of keyboard music by J. S. Bach, and forwarded the concept that the author of the text of P 803-II was the famous student of Bach J. L. Krebs. For the first time this myth was partially refuted by D. Wilson in 1979, who discovered the absolute similarity of the ornament Der Pralltriller oder Abzug in P 803-II and in the Clavierschule of G. S. Löhlein. Later Fr. Neumann wrote in more detail on this topic in his work on ornamentation (1978). The author also claimed that the anonymous copyist used the fourth edition of the Löhlein’s Klavierschule (1782) as a model for P 803-II. Thus, the assumption made by H. Zietz that P 803-II was based on the treatise by D. G. Türk (1789) turned out to be erroneous too. Studying these materials, the authors of this article drew attention to the many inaccuracies and false judgments associated with both the handwritten source P 803-II and the peculiarity of the anonymous scribe’s work with Löhlein’s text, as well as with many statements by the above-mentioned authors. It was shown that the third edition of the Löhlein’s manual on clavichord playing (1779) should have served as the primary basis for the anonymous copyist. Special attention was paid to inaccuracies and incorrect recommendations in connection with the interpretation of ornaments. A detailed consideration of the available realizations of ornaments in P 803-II and their interpretation will be established in the following second part of this paper.
Modern Chinese Oil Painting on “Tibetan Themes”
Authors:   St. Petersburg State University, Lu Zairan
Published: September 2024

Chinese fine art has undergone a long and painstaking history of the formation of classical writing techniques. However, the globalization processes, which also affected the spheres of artistic activity, influenced the themes of works, techniques and techniques of oil painting in China. Meanwhile, the existential and religious flavor of Tibetan painting, untouched by world trends, has preserved many unique traditional principles of existentialism and worldview concepts that have absorbed the virginity of the spiritual and semantic identity of the people. This phenomenon has attracted a lot of attention from professional artists and collectors of fine art. At the same time, the storehouse of unique Buddhist values and the foundations of the existence of the people of historical Tibet began to attract researchers and artists relatively recently. Namely, since the middle of the last century, eminent masters of the brush have only discovered this “art residence”, instantly capturing the market of connoisseurs of high culture and lovers of painting with their works, gaining their love for Tibetan chronography reflected in modern Chinese oil paintings. The canvases represent the value potential for the historiography of the ancient people, conglomerating the foundations of ontological, ethnic, regional, national and religious traditions of the original style, which determine the semantic value-forming core of Chinese culture. This phenomenon contributes to its continuity and self-identity, despite the influence of Western artists. The development of Chinese oil painting has undergone many collisions, ranging from Westernization, Russification and the consequences of the war with Japan, ending with the discovery of the value potential of the worldview system of the Tibetan people. The recognition of Chinese sovereignty over Tibet allowed China to integrate into its “art workshop” the spiritual and social perspectives of the national identical Tibetan culture, which conquered the art world with its identity. In the process of the formation of oil painting, artists subjected it to nationalization and Sinification, which, through the prism of depicting the realities of Tibetan life, allowed to form an original style of creating works.
Operа in the Silent Film: The Case of “Der Rosenkavalier”
Authors:   Moscow State Conservatory, Vlasova Natalia O. ,   State Institute for Art Studies
Published: September 2024

The article deals with the production history of the film “Der Rosenkavalier”, shot in 1925 by director Robert Wiene based on the popular opera of the same name by Richard Strauss and Hugo von Hofmannsthal. The peculiarity of the film was that by the time of filming the musical accompaniment for it already existed. Based on an opera score, it was prepared under the supervision of Strauss by composer Otto Singer and conductor Karl Alwin. The music of the opera was shortened and rearranged, supplemented by other works by Strauss (mainly marches intended for military scenes). The film had to adapt to the musical accompaniment, which played a leading role in this film production. The article examines the relationship between opera and film: transformations of the plot, rethinking of characters, changes in the musical score. The film is not an exact reproduction of the opera. Although its main plot motifs are preserved, they are transformed and enriched with new situations. The most noticeable change is the introduction of a new character, Marshall. The film makes extensive use of the possibilities of cinema to show a variety of locations, flashbacks, and outdoor crowd scenes. Both of the most complex characters, Marshall and Baron von Ochs, appear in the film as psychologically more ordinary. The spirit of well-behaved happy ending prevails at the end of the film, where three couples unite. For the film’s score, there is an obvious desire to preserve as much as possible the individual musical characteristics, as well as the most important tonal centers of the opera. Like an opera, a film score is united by leitmotifs, but in the film some of them take on a different meaning: the emphasis shifts from the presentation of character to the affect conveyed by the theme. The changed relationship between music and action in the frame sometimes leads to a rethinking of the characters’ behavior (Ochs). The restoration of a film that was considered lost in the 2000s makes it possible to evaluate it as a one-of-a-kind experiment from the era of early cinema.
Sofonisba Anguissola: “Celebre”, “Forgotten” or “Great”? The Main Problems in the Historiography of Creativity
Authors:   Russian State University for the Humanities, Novikova Ekaterina S.
Published: September 2024

Every year the women’s art becomes more and more relevant issue: interest to the women’s art in common and to its individual representatives is growing. Sofonisba Anguissola, due to a lot of documentary evidences and a fairly large pictorial heritage, is an important figure for understanding the general problems of female creativity in the 16th century. In Russia, the artist is still little known, and information about her in works is mostly very general and often contains inaccuracies and errors, which determines the relevance of the study. The purpose of this article is to analyze the historiography of S. Anguissola’s work, which would allow to define the current state of affairs in the issue of understanding of the topic, as well as to identify problems and prospects related to the consideration of her art, which has been evaluated in different ways since its first mention in the literature. The 16th and 17th centuries biographers talked about her mostly in a rather high tone. Art connoisseurs, without detracting from her skills, noted that she adopted too much from other artists. With the rise of feminist art studies, the perspective of S. Anguissola’s work has changed towards greater appreciation. In modern literature there are scientific works that demonstrate new aspects and approaches to the study of the artist’s art, such as pedagogical view of her works, the degree of influence of various masters, her staying in Spain, the artistic specificity of self-portraits. Comprehensive study of the S. Anguissola’s art allows not only to identify the artistic features of her works, but also to consider the socio-cultural context in which she lived and worked. In the conditions of the development of modern art history, marked by a growing popularity of gender studies, the balanced approach to the artist biography and to her art is a necessary quality for a scientist to correctly understand her place in the history of art.
Wooden Church Architecture of Kargopol and the River Onega Areas in 17th–18th Centuries
Authors:   St. Petersburg State University, Khodakovsky Evgeny V. ,   ANO “Research and Restoration of Wooden Architecture Monuments ‘Tradition’”
Published: September 2024

The article is devoted to the analysis of the typological diversity and artistic and expressive means of wooden church architecture of Kargopol’ area in the 17th–18th centuries — one of the most interesting regions of the Russian North. An examination of the configurations of the roofing of the main volumes demonstrates the widespread existence of various types. The cube-shaped churches of Kargopol’ area represent a significant part of the monuments of this typological subspecies, also localized in the Lower Onega River and southern White Sea region. At the same time, in Kargopol’ area there is a concentration of temples with a wedge roof and a “barrel” top. The research of spatial solutions shows that the octagonal churches of Kargopol’ area stand out noticeably against the background of such universal and extra-regional compositions as “an octagonal structure on a quadrangle with a refectory” or cross-planned churches. Tower-shaped churches, like the six-walled bell towers of Kargopol’ area, can also be seen against the background of the fortification architecture in the Lower Onega River, which received a powerful impetus in the 17th century in connection with the construction of the Kargopol, Ust-Mosh and Turchasovsky forts. Kargopol refectories “with free communication” are also becoming a kind of local phenomenon. The main feature of the ensemble character of Kargopol architecture is the connection between the constituent elements with the help of porches, galleries and passages. Field surveys of monuments and the use of archival sources on the history of temple construction in Kargopol’ area testify to the colossal creative potential that was fully realized during the 17th–18th centuries in the picturesque variety of forms of both individual monuments and general ensemble solutions. No less important is the fact that the Kargopol’ tradition did not remain closed in itself; its spread to adjacent regions and interweaving with the architecture of the Lower Onega River and on the White Sea coasts scales up the architecture of Kargopol’ area and makes it one of the most striking and large phenomena in the wide panorama of wooden architecture monuments throughout the Russian North.
Some Questions of Artistic Design of the “New Testament” of 1702 from the Collection of the State Hermitage
Authors:   State Hermitage Museum, Maltseva Olga N. , Zapadalova Polina V. ,   State Russian Museum
Published: September 2024

This article is devoted to the precious frame of the “New Testament”, which was published in the Moscow Print House in 1702. This book was presented by Stefan Yavorsky to tsarevich Peter Petrovich, who was born on October 28, 1715. After the death of Alexander II (1881), the book was placed in the sacristy of the Great Church of the Winter palace. The small book represents a bright work of the culture of Peter the Great’s time. Its precious decoration should be dated to the time between 1702 and 1715. The gift made to the prince by the Ryazan Metropolitan is connected with the biography of this church hierarch, known primarily as the author of sermons, but also as customer of icons. The date of the presentation of the “New Testament” (November 12, 1715) to Peter Petrovich is close to Stephen’s letter to Peter (November 14), in which the Metropolitan congratulated him on the birth of his son and prayed to let him go to Nizhyn to consecrate the church, “to offer there a sacrifice for the newborn prince”. This is the matter of the main church of the Nizhyn Monastery, founded by Stephen himself. A precious gift, decorated with gems, was supposed to strengthen the petition of the Ryazan Metropolitan. The composition of the frame includes minuscule icons with images of four evangelists and Crucifixion. They were created by one of the best Moscow icon painters from the early 18th century and show him as a great connoisseur of the art of icon painting. Shoulder-mounted images of the evangelists and the Crucifixion of Christ are executed in the traditions of icon painting of the Armory Chamber and belong to the monuments of the leading stylistic trend in Moscow painting of the late 17th — early 18th centuries. The general composition of the decoration of the New Testament frame goes back to the design of the luxurious liturgical Gospels.
Protagonismo Feminino no Rio Grande do Norte
Authors: Crislany da Silva Ferreira Vanderlânia , Carolina Beserra Brasileiro Cyntia , Gislâne Cavalcante Alves Iáscara
Published: September 2024

Este trabalho analisa o cenário eleitoral brasileiro para a disputa ao cargo de governador nas eleições de 2018 e 2022 através do recorte de gênero. Diante de um panorama em que cada vez mais se tem discutido a importância das mulheres e a eficácia de suas gestões para o exercício democrático, lançou-se como questionamentos: Quantas mulheres lançaram candidatura ao cargo de governador nas eleições no período de 1998 a 2022? Quantas mulheres foram eleitas? Como se dá a participação feminina nas eleições majoritárias? E quais são as regiões que mais têm se destacado na efetiva candidatura de mulheres ao referido cargo? A abordagem metodológica baseou-se em dados quantitativos, ao buscar no site do Tribunal Superior Eleitoral (TSE) os números das eleições nos anos supracitados; bem como dados qualitativos, ao direcionar a atenção a jornais, páginas oficiais e entrevistas para traçar o perfil da candidata eleita no RN. Como resultado, conseguimos visualizar que os dois estados que predominam na representação de mulheres como governadoras estão no Nordeste. No caso específico da eleição de Fátima Bezerra, a não existência de um capital familiar ressoa como alternativa aos cidadãos potiguares — mesmo com a dificuldade enfrentada por mulheres — para elegerem-se em cargos mais destacados da política institucional, pois, embora as cotas de gênero existam, elas são destinadas às candidaturas proporcionais, e nada é feito com relação às candidaturas majoritárias.
Bioinformatics Analysis Screening and Identification of Key Biomarkers and Drug Targets in Human Glioblastoma
Authors: Wang Chunlei , Beylerli Ozal , Gu Yan , Xu Shancai , Ji Zhiyong , Ilyasova Tatiana , Gareev Ilgiz , Chekhonin Vladimir
Published: September 2024

Background:

Glioblastoma is the most common type of brain cancer, with a prognosis
that is unfortunately poor. Despite considerable progress in the field, the intricate
molecular basis of this cancer remains elusive.

Aim:

The aim of this study was to identify genetic indicators of glioblastoma and reveal the
processes behind its development.

Objective:

The advent and integration of supercomputing technology have led to a significant
advancement in gene expression analysis platforms. Microarray analysis has gained
recognition for its pivotal role in oncology, crucial for the molecular categorization of tumors,
diagnosis, prognosis, stratification of patients, forecasting tumor responses, and pinpointing
new targets for drug discovery. Numerous databases dedicated to cancer research, including
the Gene Expression Omnibus (GEO) database, have been established. Identifying
differentially expressed genes (DEGs) and key genes deepens our understanding of the initiation
of glioblastoma, potentially unveiling novel markers for diagnosis and prognosis, as well
as targets for the treatment of glioblastoma.

Methods:

This research sought to discover genes implicated in the development and progression
of glioblastoma by analyzing microarray datasets GSE13276, GSE14805, and
GSE109857 from the GEO database. DEGs were identified, and a function enrichment analysis
was performed. Additionally, a protein-protein interaction network (PPI) was constructed,
followed by module analysis using the tools STRING and Cytoscape.

Results:

The analysis yielded 88 DEGs, consisting of 66 upregulated and 22 downregulated
genes. These genes' functions and pathways primarily involved microtubule activity, mitotic
cytokinesis, cerebral cortex development, localization of proteins to the kinetochore, and the
condensation of chromosomes during mitosis. A group of 27 pivotal genes was pinpointed,
with biological process analysis indicating significant enrichment in activities, such as division
of the nucleus during mitosis, cell division, maintaining cohesion between sister chromatids,
segregation of sister chromatids during mitosis, and cytokinesis. The survival analysis
indicated that certain genes, including PCNA clamp-associated factor (PCLAF), ribonucleoside-
diphosphate reductase subunit M2 (RRM2), nucleolar and spindle-associated protein
1 (NUSAP1), and kinesin family member 23 (KIF23), could be instrumental in the development,
invasion, or recurrence of glioblastoma.

Conclusion:

The identification of DEGs and key genes in this study advances our comprehension
of the molecular pathways that contribute to the oncogenesis and progression of
glioblastoma. This research provides valuable insights into potential diagnostic and therapeutic
targets for glioblastoma.
In Silico and In Vitro Evaluation of Bioactive Compounds of Vallisneria spiralis L. against Candida albicans
Authors: Waykar Ravindra , Kumarapillai Srinivasakumar
Published: September 2024

Background

This study focused on the extraction, isolation, characterization, and molecular docking of phytochemicals from Vallisneria spiralis L. to determine its antifungal activity. Natural products and structural analogs have always played an important role in pharmacotherapy, particularly in the treatment of infections and malignancies.

Methods

Vallisneria spiralis L. leaves were pulverized into a fine powder and extracted using a Soxhlet apparatus, and the crude chloroform extract was separated by flash column chromatography. Thin-layer chromatography was used to assess the obtained fractions. Infrared spectra were obtained using a Perkin Elmer spectrometer. NMR spectra were collected using a Bruker spectrometer. Qualitative phytochemical investigations were performed to identify compounds in the extracts. The susceptibility of the test compound to Candida albicans was assessed using disk diffusion. A docking study was conducted to dock the three-dimensional structures of the extracted phytocompounds of Vallisneria spiralis L. into the receptor site of the target proteins using Autodock software. MD simulations were used to study the dynamic behavior, conformational changes, and stability of the proteins using the top three hit chemicals.

Results

These results suggest that Vallisneria spiralis L. extract contains various phytoconstituents, including carbohydrates, tannins, flavonoids, steroids, terpenoids, and glycosides. The distinctive functional groups of the extract were identified using a Fourier-Transform Infrared (FTIR) spectrophotometer. Nuclear Magnetic Resonance (NMR) spectroscopy was used to determine the structures of the isolated and purified extracts. The antifungal activity of Vallisneria spiralis L. extract against Candida albicans was found to be significantly stronger at a concentration of 200 mg/mL.

Conclusion

The findings of the study were obtained using in vitro and in silico methods to investigate the antifungal effect of Vallisneria spiralis L., which highlighted it as a potential natural antifungal treatment for Candida infection, which could be further investigated.
Disputa del método en Economía: monismo vs. pluralismo
Authors:   Universidad Rey San Carlos, Sánchez-Bayón Antonio , Arpi Roberto ,   Universidad Nacional del Altiplano
Published: September 2024

Introducción: Revisión crítica de Economía Política sobre la disputa del método en Economía y la reactualización de su debate para revisar el estado del conocimiento económico y afrontar así, sus retos en curso. Dicha disputa parte de la anterior, relativa a la renuncia teórica y el exceso instrumental y aplicado de la Economía con la Síntesis Neoclásica, alejándose con sus modelizaciones de la realidad y sus cambios, además de generar un malestar estudiantil. Objetivo: Sintetizar el desarrollo de las disputas del método según la Escuela Austriaca, para sacar a la Economía del ámbito de las Ciencias Naturales e Ingenierías, y sus reducciones a modelos de equilibrio y excesos matemáticos. Metodología: se recurre a los marcos teóricos y metodológicos de la Escuela Austriaca, compartidos con otros enfoques heterodoxos de fundamentos (Neoinstitucionalistas), para contrastarlos con los préstamos de Ciencias Naturales e Ingenierías y asumidos por la Síntesis Neoclásica, con la pretensión más predictora que realista. Resultados: se sistematizan los principales problemas del conocimiento económico y cómo corregirlos (científica y docentemente) para transitar a la Economía del conocimiento y la complejidad. Conclusiones: la actual disputa del método no sólo permite recuperar los fundamentos de la Economía (vía giro hermenéutico y revolución copernicana en la ciencia y en su docencia), sino también su reconexión con las Ciencias Sociales y la cambiante realidad social. Se favorece también el tránsito a la Economía del conocimiento y la complejidad, y se evidencia la secular polémica de desarrollistas vs. decrecentistas.
Enhancing antibacterial activity through green synthesis of silver nanoparticles with salvia officinalis extracts
Authors:   Department of Botany and Microbiology, College of Science, Female Campus, King Saud University, Riyadh 11451, Saudi Arabia, Altuwaijri Yara A. , Alshiekheid Maha A. ,   Department of Botany and Microbiology, College of Science, Female Campus, King Saud University, Riyadh 11451, Saudi Arabia, Aldosari Noura S. ,   Department of Botany and Microbiology, College of Science, Female Campus, King Saud University, Riyadh 11451, Saudi Arabia, Alghamdi Mai A. ,   Department of Botany and Microbiology, College of Science, Female Campus, King Saud University, Riyadh 11451, Saudi Arabia, Moubayed Nadine M. S. ,   Department of Botany and Microbiology, College of Science, Female Campus, King Saud University, Riyadh 11451, Saudi Arabia
Published: September 2024

This study aimed to test the effectiveness of water-based extracts and green-synthesized silver nanoparticle extracts from the Salvia officinalis plant in killing bacteria. We used the agar well diffusion method to see how well these extracts could fight against both Gram-positive bacteria (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). To understand the properties of the nanoparticles, we analyzed them using a UV-VIS spectrophotometer and a scanning electron microscope (SEM). The results showed that both types of extracts were effective against the bacteria, with performance similar to the antibiotic chloramphenicol used as a benchmark. An interesting finding was that combining the plant extracts with the antibiotic or the silver nanoparticle extract with the antibiotic significantly enhanced the ability to stop bacterial growth in all tested strains. The Gram-positive bacteria were more affected than the Gram-negative ones, suggesting a potential way to overcome bacterial resistance.