bluuebunny/crossref_metadata_2025 huggingface dataset:
Desempenho ocupacional nas atividades de vida diária de pacientes pós revascularização do miocárdio
Authors: Lourenço Priscila Barros , Maciel Marly Lobato , Barbosa Ivone Soares , Castro Ana Paula de Souza Pedrosa , Corrêa Roberta de Oliveira
Published: March 2024

Objetivo: Analisar o desempenho ocupacional nas Atividades de Vida Diária (AVD’s) pós ReVascularização do Miocárdio (RVM) de pacientes internados em um hospital de referência do estado do Pará. Métodos: Trata-se de estudo transversal, descritivo e quanti-qualitativo. Realizado com 20 pacientes, de ambos os sexos, com idade média = 61,1 anos, que passaram por cirurgia de RVM em um hospital de referência, no período de setembro a outubro de 2023. Resultados: No desempenho ocupacional todos os pacientes apresentaram leve dependência nas AVD’s pós RVM, as atividades mais comprometidas nesse período de recuperação foram: banho, atividades rotineiras, vestir-se, uso do toilet, transferência e mobilidade e quanto aos motivos que o levam a dependência sendo os mais citados, dor, medo e orientações profissionais. Conclusão: Conclui-se que temos dois perfis de paciente pós RVM, o menos e o mais ativo e que todos apresentaram dependência, em pelo menos, duas atividades, assim sendo imprescindível a atuação do terapeuta ocupacional junto a equipe multiprofissional para as orientações desses pacientes tanto no pré, quanto no pós cirúrgico e retorno domiciliar, para adaptar suas atividades e a fim de melhor desempenho ocupacional nas suas AVD’s.
Sobretratamento excisional ambulatorial do colo uterino: histologia negativa para atipias
Authors: Pereira Nathana Cristina Freitas , Souza Sádia Martins de Paula , Souza Nádia Martins de Paula
Published: March 2024

Objetivo: Avaliar o perfil epidemiológico das pacientes submetidas a eletrocirurgia do colo uterino cujo resultado histológico foi negativo e investigar as indicações de EZT e os fatores que favoreceram tais resultados, reduzindo, assim, procedimentos desnecessários e superestimação da citologia e da biópsia. Métodos: Foi realizado um estudo retrospectivo, quantitativo, transversal, descritivo e observacional envolvendo pacientes que apresentaram histologia negativa para atipias após realizar EZT do colo uterino no período de janeiro de 2021 a dezembro de 2022, em um hospital público do Distrito Federal. Resultados: Foram incluídas no estudo 76 pacientes que atenderam aos critérios de inclusão. A maioria delas tinha entre 30 e 49 anos e 50% eram multíparas. A alteração citológica mais frequente foi ASCH, seguida de HSIL. A colposcopia mostrou que 30,3% apresentaram achados maiores. Cerca de 32% das pacientes realizaram biópsia incisional. Conclusão: Conclui-se que novas estratégias diagnósticas antes da EZT devem ser implementadas no serviço na tentativa de reduzir o tratamento excessivo.
Perspective: Operate on lumbar synovial cysts and avoid ineffective percutaneous techniques
Authors: Epstein Nancy E. , Agulnick Marc A.
Published: March 2024

Background:

Lumbar synovial cysts (LSC), best diagnosed on MR studies, may cause symptoms/signs ranging from unilateral radiculopathy to cauda equina compressive syndromes. Attempts at percutaneous treatment of LSC typically fail. Rather, greater safety/efficacy is associated with direct surgical resection with/without fusion.

Methods:

Treatment of LSC with percutaneous techniques, including cyst aspiration/perforation, injection (i.e., with/without steroids, saline/other), dilatation, and/or disruption/bursting, classically fail. This is because LSCs’ tough, thickened, and adherent fibrous capsules cause extensive thecal sac/nerve root compression, and contain minimal central “fluid” (i.e., “crank-case” and non-aspirable). Multiple percutaneous attempts at decompression, therefore, typically cause several needle puncture sites risking dural tears (DT)/cerebrospinal fluid (CSF) leaks, direct root injuries, failure to decompress the thecal sac/nerve roots, infections, hematomas, and over the longer-term, adhesive arachnoiditis.

Results:

Alternatively, many studies document the success of direct or even partial resection of LSC (i.e., partial removal with marked cyst/dural adhesions with shrinking down the remnant of capsular tissue). Surgical decompressions of LSC, ranging from focal laminotomies to laminectomies, may or may not warrant additional fusions.

Conclusions:

Symptomatic LSC are best managed with direct or even partial operative resection/decompression with/without fusion. The use of varying percutaneous techniques classically fails, and increases multiple perioperative risks.
Korelasi Penguasaan Kosakata dengan Keterampilan Menulis Teks Berita Siswa Kelas VIII SMP Kartika Pekanbaru
Authors: Lestari Febby Nabila , Septyanti Elvrin , Zulhafizh Zulhafizh
Published: March 2024

This study aims to determine the relationship between vocabulary skills and news text writing skills. The study involved a sample of class VIII students at SMP Kartika 1-5 Pekanbaru. The research is quantitative, using correlation as the method. The data used consists of objective tests and performance evaluations. The results of the data analysis indicate that the student's vocabulary mastery level was classified as good, with an average of 74.636, while their ability to write news texts was also classified as good, with an average of 77.634. The data analysis reveals a significant relationship between vocabulary skills and news text writing skills. This relationship is evident from the correlation coefficient value tested using the Pearson product-moment correlation formula. The calculations demonstrate that the value of the count is 0.962, which is greater than r table (0.2681), indicating a genuine correlation between variable X and variable Y. According to the interpretation table for correlation levels, this falls into the high category, within the scale of 0.80-1.00. Hypothesis testing using the t-test and f-test, with a 95% confidence level and degrees of freedom (dk) = n-2, yielded values of 4.761 > 1.675 and 653.343 > 4.02, respectively. Therefore, H0 is rejected, and H1 is accepted, as the hypothesis testing results prove a significant positive correlation of 96.2% between vocabulary skills and news text writing skills among class VIII students of SMP Kartika 1-5 Pekanbaru. Keywords: ability, vocabulary, writing news text.
Pengembangan Bahan Ajar Apresiasi Puisi Berbasis Pendidikan Karakter dalam Syair Nasib Melayu Karya Tenas Effendy
Authors: Rahayu Sri , Ningsih Rika , Andika Zaldi , Sukmawati Rina
Published: March 2024

This research is motivated by the importance of increasing character education for students. The decline in character or morals in students is of great concern to the world of education. There are lots of deviant or immoral behaviors being carried out by students today including the use of illegal drugs/narcotics, free sex and many other deviant behaviors that can put a black mark on the world of education. Improving character education can be done through the development of poetry appreciation teaching materials on aspects of the poetic genre in the form of poetry. The purpose of this research is to find out whether teaching materials for poetry appreciation, especially poetry, are oriented towards improving character education for students. The research approach used in this research is a qualitative approach with a research method that is descriptive analytic. As a qualitative research, it is descriptive in nature as data analysis and the results of the analysis are in the form of phenomena from all the wealth of information about the implementation of learning poetry appreciation. The level of success will be measured by the assessment matrix from the results of tests and interviews. Character values ​​are taken from eighteen values ​​from the results of the Ministry of National Education's study.
Tutur Kata Penonton Piala Dunia 2022
Authors: Andi Saadillah  , Saputra M Muhammad Randi , Satria Yunan Mahastra
Published: March 2024

2022 World Cup international event. Furthermore, the context of the audience's speech while watching together provides an overview of how Indonesian people express themselves through speech when watching World Cup matches. The purpose of this study is to explore the forms of speech acts by the public during collective World Cup viewing. The research was conducted in the city of Kolaka, Southeast Sulawesi, using qualitative research methods. Data collection techniques included observation, recording, note-taking, and interviews. Based on the described research results, the identified forms of speech acts tend to be expressive and emotional. Declarative speech acts accounted for 6 instances, imperative speech acts for 4 instances, and interrogative speech acts for 4 instances. The audience's speech patterns were influenced by factors such as the atmosphere, gender, and age. The study findings illustrate the dynamic nature of the audience's response, as the unpredictable World Cup matches often exceeded the audience's expectations. Consequently, people's words when watching the 2022 World Cup together could change depending on the ongoing match situation and conditions. Emotions such as joy, disappointment, sadness, annoyance, and disbelief were common expressions witnessed during these matches.
Tindak Tutur dalam Iklan Lebaran Mr.Diy 2022 “Kembali Ke Pangkuan”
Authors: Wibisono Yudhi Kurniawan
Published: March 2024

Advertising is one of the strategies employed by producers to promote their products or services. The purpose of this research is to analyze the discourse in the MR.DIY 2022 Eid advertisement "Kembali ke Pangkuan" available on the MR DIY Indonesia YouTube channel. The study aims to describe and identify the types of discourse and their functions in the advertisement. This research adopts a qualitative approach, and the research data consist of speech fragments that reflect illocutionary speech acts. The data source for this study is a video recording of the advertisement. Data collection was conducted using observation and note-taking techniques (advanced techniques). Data analysis was performed using a qualitative data analysis model according to Miles and Huberman, which involved data reduction, data presentation, and data inference. The findings of this study indicate the presence of 22 illocutionary speech acts in the MR.DIY 2022 Eid advertisement "Kembali ke Pangkuan". The types of utterances include: (1) 4 instances of assertive speech acts, (2) 7 instances of directive speech acts, (3) 7 instances of expressive speech acts, (4) 3 instances of commissive speech acts, and (5) 1 instance of declaration speech act.
Kasus Argumen Inti Verba Bahasa Muna di Sulawesi Tenggara
Authors: Alu La , Sarmadan Sarmadan
Published: March 2024

The Muna language serves as both a social language and a means of communication within the Muna sociocultural area, actively used and mastered by its speakers. The objective of this study is to uncover linguistic facts, specifically those related to the core argument cases of verbs in the Muna language. The research employs a descriptive method aimed at providing an accurate description of the data, characteristics, and relationships of the phenomena under investigation. The research findings reveal various verb core argument cases in the Muna language, including: (a) Stative verb core argument cases, which encompass (i) basic stative verb core argument cases, (ii) stative experiential verb core argument cases, (iii) stative verb core argument cases involving ownership, and (iv) core argument cases of locative stative verbs. (b) Core argument cases for process verbs, which consist of (i) basic process verb core argument cases, (ii) process experience verb core argument cases, (iii) process verb core argument cases involving ownership, and (iv) core argument cases of locative process verbs. (c) Action verb core argument cases, which include (i) basic action verb core argument cases, (ii) action experience verb core argument cases, (iii) action verb core argument cases involving possession, and (iv) core argument cases of locative action verbs.
Rekonstruksi Religiositas Etnik Melayu Dimensi Keyakinan pada Kitab dalam Puisi Melayu Tradisional
Authors: Roziah Roziah
Published: March 2024

The nature of being open to immigrants makes ethnic Malays exposed to various crimes such as fraud, physical violence, sexual violence, murder, theft, corruption,  and the use of illegal drugs involving perpetrators who are Malay nationals or perpetrators who live in the Malay area, which continues to increase every year. the year. the year. This increase in crime rates shows that people in the Malay area are experiencing a decline in character. There have been various speculations that cultural customs, teachings, and advice on trust are no longer respected, or perhaps those who live in the Malay area have not been given teachings regarding the noble values of Malay culture, which are based on the Koran. Therefore, the dimension of religiosity related to Malay ethnic beliefs in the book needs to be reconstructed and internalized with the aim of strengthening Malay ethnic beliefs, and people living in Malay areas believe in the Koran as a guide to life. A descriptive qualitative study was completed through stylistic, semiotic, and hermeneutic approaches to traditional Malay poetry. The research data is in the form of rhymes, poetry, and expressions contained in Tenas Effendy's works. The data sources for the study come from four books. (1) Tunjung Ajar Melayu in Pantun Gurindam and Seloka; (2) Pantun Nasihat; (3) Syair Nasib Melayu; and (4) Tangkat Ajar Melayu: Details of Riau Malay Culture. Data was collected through reading, noting, and interpreting techniques, then coded to count the number of occurrences using the AnCont application. The validity of the data goes through a verification and validation process by experts in the fields of literature, Malay, and religion. Malay ethnic faith in the Koran appears in several categories, namely: (1) knowing God by devoutly reading the Koran; (2) Ethnic Malays use the Koran as Imam; (3) encouraging children to honor the Koran; (4) customary lines that are based on syarak and syarak based on the Book of Allah; (5) diligently listening to the reading of the Koran is believed to expand knowledge; (6) making the Koran a guide for life; and (7) diligently studying the Koran as a sign of Malay luck. The reconstruction of the religiosity dimension of belief in books shows that traditional Malay poetry is a literary work that contains a call to amar maruf nahi mungkar. It is hoped that this study can have implications for learning. Riau Malay culture in schools and oral literature in universities.
Reduplikasi Bahasa Melayu Riau Subdialek Pangean
Authors: Aulia Niken , Charlina Charlina , Septyanti Elvrin
Published: March 2024

This research aims to identify the form and meaning of reduplication in the Riau Malay language, the Pangean subdialect. This research is descriptive research with data collection techniques by fishing, listening, engaging, speaking, recording, and taking notes. The data analysis technique used is listening again to the recording during the research, then continuing to present the data, and drawing conclusions from the analysis that has been carried out on the data. Based on the research results, 103 data were obtained with the classification of full form reduplication, partial form, affixed form, and phoneme change form. As for meaning, namely stating many meanings, stating unconditional meaning, stating similar meanings, stating that actions are carried out repeatedly, stating that actions are done at will, stating that actions are carried out by two parties regarding each other, stating things related to work, stating somewhat meaning, expressing the highest level meaning, expressing the meaning of intensity of feeling.
Refleksi Pesan Kesehatan Mental Dalam Lagu “Satu Kali” Karya Tulus: Analisis Wacana Kritis
Authors: Raudha Farhania Amama , Abrian Rizky
Published: March 2024

This research aims to analyze the song "Satu Kali" by Tulus using discourse analysis methods to understand messages related to mental health in the lyrics. The method used is a qualitative approach with a note-taking approach. In this study, researchers analyzed the lyrics of the song "Satu Kali" in depth, focusing on verses related to mental health. A note-taking approach is used to note down and understand the meaning contained in the lyrics. Researchers looked for the messages that Tulus wanted to convey and analyzed how the lyrics could provide an in-depth understanding of maintaining mental health. The research results show that the song "Satu Kali" by Tulus succeeded in conveying mental health messages well through its lyrics. In the six verses analyzed, the lyrics of this song contain important messages about overcoming life's stresses, self-acceptance, and maintaining emotional balance.
Memanifestasi Deiksis dalam Film “Ngeri-Ngeri Sedap” Karya Bene Dion Rajagukguk: Analisis Pragmatik
Authors: Amaniyah Dita Zuaimatul , Rumilah Siti
Published: March 2024

This research aims to analyze the use of deixis in the film "Ngeri-Ngeri Sedap" from a pragmatic perspective. Deixis is an important aspect in linguistic studies which is related to the use of signs that refer to the context of space and time. The film text analysis method is used to identify and analyze the use of deixis in the context of situations involving characters, location, time, and interactions between characters. The research results show that the use of deixis in this film aims to create a communicative effect and build relationships between the characters and the audience, by using personal, time, place, atmosphere, and social deixis. The use of pointing signs, such as body gestures and the placement of objects in scenes, is used to clarify the spatial relationships between characters and objects in the story. Pronouns are also often used to replace previously introduced references, maintaining cohesion in the narrative. In addition, the effective use of time-telling words helps the audience understand the sequence of events and establish chronology in the story. This research provides deeper insight into the use of language in communicative situations in the context of films, as well as a contribution to the development of pragmatic theory and an understanding of the audience's experience.
Mariah Dalam Novel Terusir Karya Buya Hamka dengan Kajian Analisis Wacana Kritis Sara Mills
Authors: Juliana,  S. Juliana , Charlina Charlina , Burhanudin Dudung
Published: March 2024

This research aims to describe the subject-object position and the writer-reader position regarding the position of women in the novel Terusir by Buya Hamka. This research is qualitative descriptive research. The subject position in this research is the author who tells the reader about a weak and deluded woman. The position of object of this research is the position of a character named Mariah who was divorced and thrown out by her husband because of slander from her husband's family, so she became a prostitute. The data for this research were obtained from an analysis of the novel published by Gema Insani in 2016. The results of this research show the position of a subject-object in the story, where women are weak objects have no power in the household, and are not strong enough to maintain their identity because conditions are increasingly cruel. Meanwhile, the subject position leads readers to sympathize with weak women who should be allowed to defend themselves from the slander they receive, so that they do not have to be divorced and thrown out by their husbands.
Grammatical Cohesion in Joe Biden’s Speech: An Analysis
Authors: Nurul Candra Eva , Martiarini Elyza , Reknosari Reknosari
Published: March 2024

The aim of this research is to analyze the use of grammatical cohesion in Joe Biden’s victory speech as well as to find out the use of the most dominant type of grammatical cohesion in Jo Biden’s victory speech. The research method used is descriptive qualitative method. The data source was obtained from downloading a video in the form of a text transcript of Joe Biden’s victory speech, then identifying the use of grammatical cohesion. The types of grammatical cohesion which are the focus of this research are reference, substitution and conjunction. From the results of the analysis found the use of grammatical cohesion namely reference (174), substitution (22), Ellipsis (0) and conjunction (101). Thus, from this data, it can be concluded that in Joe Biden’s victory speech there was a lot of grammatical cohesion
Games in Acquiring First and Second Language Skills
Authors: Leztiyani Indirawati , Nuryani Nuryani
Published: March 2024

Humans are born with tremendous potential in the ability to think. The development of this thinking is a gradual process, with the most critical period occurring during childhood, often referred to as "The Golden Age" During this time, the ability to think develops rapidly, but keep in mind that this development must be maintained so that it is not inhibited or atrophied. In the early stages of a child's thinking development, the most striking abilities are speech and walking. Speaking, in particular, is heavily influenced by the environment and the role of parents in shaping the child's first language. A child's second language, on the other hand, is often acquired during the school years with the guidance of teachers. To develop first and second language skills, games are an effective and fun method. Games such as drawing, singing, word scramble, gardening, word puzzles, finding missing letters, counting and storytelling can be used. After analyzing various games by involving parents and teachers as assessment subjects, it was found that counting and singing games are very effective and preferred. Both games provide many benefits, including ease of implementation, motor development, increased thinking power, child confidence, and support from various musical and mathematical instruments. The counting and singing games can also be adapted to different languages, which supports children in their learning.
The Effect of Discovery Learning on Students' Essay Writing Skills
Authors: Martin Yuliani Olvi , Sri Hartati Yulia , Pebriani Yulia
Published: March 2024

The purpose of this study was to find out how the discovery learning paradigm affects the ability to write essays for class XI students of SMA Negeri 9 Padang. The methodology used in this research is explorative. One group participated in the pretest-posttest design selected for this investigation. The sample of this research was F4 class students of SMA Negeri 9 Padang, which consisted of 36 students. The educational tool consists of several sections, such as training modules, workbooks specifically designed to help students improve their essay writing skills, and performance tests to measure students' specific essay writing skills. By using the SPSS 25 for Windows program, data analysis was carried out to find out how the discovery learning paradigm influences student learning outcomes. This distribution is in accordance with the normal distribution, according to the findings of the normality test performed on the pretest data. The average value is calculated to be 60.94, and this result is based on the fact that the significance value (0.078 0.05) is greater than a predetermined threshold. The findings of the posttest data normality test confirm that the distribution is normal. The mean value of 77.77 and a significance level of 0.094, which is higher than the intended cutoff of 0.05, indicates this. The results of the significance test showed that the application of the discovery learning strategy had a statistically significant effect on the ability of class XI students of SMA Negeri 9 Padang in composing essays. This conclusion is reached using a significance level of 0.05 (p 0.05). Thus, it can be stated that the use of discovery learning methodology in eleventh grade students of SMA Negeri 9 Padang has a significant effect on their writing ability.
Repetition of Epizeuksis in the Poetry Collection the Road to Your Home The Work of Acep Zamzam Noor
Authors: Armet Armet
Published: March 2024

This research is motivated by the fact that poetry is one of the most popular forms of literary works presented in beautiful and imaginative language. Even poetry is considered as a series of words that describe the feelings of the author. Furthermore, the frequent use of repetition in poetry written by poets. This type of research is qualitative research. The method used in this research is descriptive analysis method. The data collection technique used in this study uses the listening method with note taking techniques. The results of the study found a form of epizeuksis repetition in the poetry collection Jalan To Rumahmu which can be seen in various poetry titles including “Di Sini”, “Lagu Fajar”, “Corso Garibaldi 138, “Senza Titolo”, “Disebuah Basilica, Assisi”, “Di Negeri Air”,“Menanti Kelahiran”, “Cerita Buat Imana Tahira”, “Montmarte”, and  “Buat Malika Hamoudi”.
Bioinspired Synthesis of (–)-Hunterine A: Deciphering a Unique Deconstructive Route
Authors: Zsigulics Bálint , Angyal Péter , Mészáros Bence Balázs , Daru János , Varga Szilárd , Soós Tibor
Published: March 2024

A short, bioinspired, and enantioselective synthesis of (–)- hunterine A, an odd 6/7/6/6/5 pentacyclic natural product, is described. The key step in the synthesis of this daunting structure is the 6-exo selective epoxide ring-opening reaction, which is interwoven with a deconstructive step of the indolenine part to create the unusual 7-membered azepine bridge motif. Our work also reveals the possible mechanism and stereochemical prerequisite of this unique skeletal rearrangement, which provides a vantage point for understanding how (–)-hunterine A is likely to be generated in nature.
In situ formation of robust nanostructured Cobalt oxyhydroxide / Cobalt oxide oxygen evolution reaction electrocatalysts
Authors: Zhao Yupeng , Gao Dandan , Biskupek Johannes , Kaiser Ute , Liu Rongji , Streb Carsten
Published: March 2024

The design of efficient and stable oxygen evolution reaction (OER) catalysts-based earth-abundant metal precursors is crucial for large-scale energy conversion and storage. To-date, many catalyst materials are limited by poor stability in harsh oxidative conditions. Thus, much research is targeted at developing materials that can operate under demanding OER conditions. One promising approach is the in-situ formation of catalysts which are inherently stable under the oxidizing, alkaline conditions often used in OER studies. Here, we report how mixed metal sulfide precursors (i.e. CoMo2S4 and FeS2) which give the low overpotentials (307 mV at j = 10 mA·cm-2) at the beginning of catalysis, are converted in-situ to give a highly stable composite OER catalyst under alkaline OER conditions (1 M aqueous KOH solution, pH = 13.8). Mechanistic studies reveal that under operation, the precursor materials are converted to γ-CoOOH nanofibers and Co2O3 nanoparticles, both well-known prototype OER catalysts. The report demonstrates that the presence of crystalline mix metal sulfide precursors is critical for the simultaneous in-situ formation of the active catalysts, highlighting that use of these earth-abundant minerals might offer an economically and chemically viable route for scalable catalyst development.
Linking structure to function at the solid electrolyte interphase: Insights from NMR spectroscopy
Authors: Svirinovsky-Arbeli Asya , Juelsholt Mikkel , May Richard , Kwon Yongbeom , Marbella Lauren
Published: March 2024

The performance of Li metal batteries is tightly coupled to the composition and properties of the solid electrolyte interphase (SEI). Even though the role of the SEI in battery function is well understood (e.g., it must be electronically insulating and ionically conductive, it must enable uniform Li+ flux to the electrode to prevent dendrite growth, it must accommodate the large volume changes of Li electrodeposition), the challenges associated with probing this delicate composite layer have hindered the development of Li metal batteries for practical applications. In this review, we detail how nuclear magnetic resonance (NMR) spectroscopy can help bridge this gap in characterization due to its unique ability to describe local structure in conjunction with ion dynamics while connecting these properties to electrochemical behavior. By leveraging NMR, we can gain molecular-level insight to aid in the design of Li surfaces that enable reactive anodes for next generation, high energy density batteries.
Identification of Novel Smyd1 Inhibitors for Cardiovascular Disease Treatment through Molecular Modelling
Authors: Chen Yonghui , Schaller David , Berkholz Janine , Volkamer Andrea
Published: March 2024

Smyd1 (SET And MYND Domain Containing 1) plays a crucial role in cardiomyocyte differentiation and cardiac morphogenesis, offering promising potential for the treatment of cardiovascular disease. However, the lack of human crystal structures and published inhibitors for Smyd1 has hindered progress in developing effective therapeutics. To address this gap, our study employs computational methods to identify novel Smyd1 inhibitors. We first generated a reliable human Smyd1 homology model and conducted an in-depth analysis of the compound binding modes within the Smyd family. Subsequently, we developed and executed a virtual screening pipeline, integrating pharmacophore screening, molecular docking, and molecular dynamics simulations, to search for potential hit compounds with inhibitory activity against Smyd1. Experimental testing of the 15 most promising compounds identified three novel compounds with promising inhibitor activity, comparable or even higher to that of Sinefungin, a ligand known to bind to the Smyd1 cofactor pocket. These findings provide valuable insights into the binding mode of Smyd1 hit compounds, suggesting their potential as lead candidates. In conclusion, we present a rational approach for the discovery of potential therapeutic agents, laying the foundation for future investigations into optimizing novel Smyd1 inhibitors.
A simple software program for sorting biological sequences into unique groups.
Authors: Bassa Babu
Published: March 2024

In this communication the author describes a software tool named "ChameleonSort". The software program, developed by the present author is useful in the sorting of biological sequence variants like those accumulating mutations while diverging from the common ancestors. Examples include viral protein variants, protein isomers, protein orthologs and polynucleotide sequences like DNA and RNA (1, 2). The program sorts the query sequences into unique groups. The output includes groups of sequences with unique permutation of the monomer units (amino acids and nucleotides) where the sequences of each group are identical but different from the sequences of every other group at least at one amino acid position or different in length by at least one monomeric unit. The algorithm has been implemented in the Visual Basic language which is a component of Microsoft’s Visual Studio (3). The entire code is made available as part of supplementary data in this communication. The user friendly program is available free of cost at Github.com (4), for downloading onto Windows-10 or higher operating systems.
Oxide Encapsulated Ruthenium Oxide Catalysts for Selective Oxygen Evolution in Unbuffered pH Neutral Seawater
Authors: Bushiri Daniela , Baxter Amanda , Odunjo Onaolapo , Fraga Alvarez Daniela , Yuan Yong , Chen Jingguang , Esposito Daniel
Published: March 2024

Direct seawater electrolysis is a promising approach to producing green hydrogen in water-scarce environments using renewable energy. However, the undesirable chlorine evolution reaction (CER) and hypochlorite evolution reaction (HCER) compete with the desired oxygen evolution reaction (OER) at the anode electrocatalyst. This issue is most pronounced in unbuffered pH neutral solutions due to local acidification resulting from the OER. To overcome this challenge, this study explores the use of silicon oxide (SiOx) and titanium oxide (TiOx) nanoscale overlayers coated on metallic ruthenium (Ru) and ruthenium oxide (RuOx) thin film electrodes to block chloride ions from reaching active sites during operation in unbuffered 0.6 M NaCl electrolyte. Using a combination of (electro)analytical techniques, encapsulated RuOx anodes are shown to effectively suppress Cl- transport to buried catalyst active sites while allowing for the desired OER to occur, leading to increases in OER faradaic efficiency at moderate overpotentials. Evidence for the ability of SiOx overlayers to block Cl- ions from reaching the active buried interface was obtained by monitoring the OH stretching mode of OH adsorbates using in situ Raman spectroscopy. This study also reports trade-offs between the activity, selectivity, and stability of bare and encapsulated Ru and RuOx electrocatalysts, finding that the magnitude of these trade-offs strongly depends on the nature of both the catalyst and overlayer material. The most promising anode electrocatalyst is RuOx encapsulated by 4 nm of SiOx, which gives the largest improvement in OER faradaic efficiency while demonstrating a relatively stable operating current and minimal increases in overpotential.
Micro-alloying of Zn and Ca in Vacuum Induction Casted Bioresorbable Mg System: Perspectives on Corrosion Resistance, Cytocompatibility, and Inflammatory Response
Authors: Behera Manisha , Denys Agnes , Shabadi Rajashekhara , Allain Fabrice , Gruescu Cosmin
Published: March 2024

There is an increasing interest in biodegradable materials, such as magnesium, for orthopedic implants. This is driven by their potential to address challenges like stress shielding and the need for secondary removal surgery. In this study, biodegradable magnesium alloys were produced using the Vacuum Induction Casting technique. The impact of micro-alloying Zn and Ca in Mg-xZn-0.2Ca (x= 0.1, 0.2, 0.3, and 0.4 wt%) alloys on corrosion resistance, cytocompatibility, and early-stage inflammatory response was investigated. XRD and SEM-EDS analysis confirmed the presence of Ca2Mg6Zn3 secondary phases in all alloys. The Mg-0.3Zn-0.2Ca alloy exhibited the lowest corrosion rate and an elastic modulus of 33.7 GPa, resembling that of natural bone. Electrochemical measurements indicated a correlation between grain size and secondary phase volume fraction in explaining corrosion behaviour. In vitro degradation in simulated body fluid (SBF) for 21 days showed hydroxyapatite formation on alloy surfaces, aligning with electrochemical studies. In vitro cytotoxicity tests demonstrated the cytocompatibility of all alloys, with Mg-0.3Zn-0.2Ca having the highest cell viability over a 6-day cell culture. Investigation into the inflammatory response with RAW-Blue macrophages revealed the anti-inflammatory properties of Mg-0.3Zn-0.2Ca alloys. Micro-alloying with 0.3 wt% Zn and 0.2 wt% Ca enhanced mechanical properties, corrosion resistance, cytocompatibility, and immunomodulatory properties. This positions the Mg-0.3Zn-0.2Ca alloy as a promising biodegradable implant for bone fixation applications.
Analisis Smart Governance di Kota Makassar
Authors: Affandi Akhmad , Nawawi Juanda , Syamsu Suhardiman
Published: March 2024

This study aims to examine and analyze smart governance in Makassar City and the factors that affect it. This research was a qualitative research method using descriptive data. Data collection techniques used were observation, interview and documentation, and the data were analyzed using qualitative descriptive analysis. The results of the study show that smart governance in Makassar City has not been maximized so far. The dimensions of smart governance include smart use of ICT, smart collaboration and participation, smart decision-making, and smart administration. Meanwhile, the factors affecting it include supporting factors and inhibiting factors. Supporting factors involve the support of technology and human resources as well as the support of stakeholders and social conditions of the community, while the inhibiting factors include less supportive service facilities and service systems as well as the changes of regulation.
Pengaruh Motivasi Terhadap Kinerja Tenaga Kesehatan di Puskesmas Sinjai Barat Kabupaten Sinjai
Authors: Syam Andi Armayudi , Afdal Andi Ahmad Malikul
Published: March 2024

The study's goal was to determine how motivation affected the performance of healthcare professionals at the Tengngalembang Community Health Centre in the West Sinjai Subdistrict of the Sinjai District. In terms of the research methodology, a quantitative approach was utilised, along with a descriptive research design and methods for gathering data through questionnaires and observation. In addition to pulling the sample using saturation sampling approach, there were 35 nurses and midwives in the health centre of Tengngalembang Community West Sinjai Subdistrict of Sinjai district who were all included in this study. The findings demonstrate that motivation is the end result of a variety of internal and external processes that lead to the development of passion and perseverance in carrying out particular tasks. The results of the study show the influence of motivation on the performance of health workers in the health centre of Tengngalembang community in Sinjai subdistrict west of Sinjai district. The motivation variable can have a positive influence on the performance of health workers in the Tengngalembang community health centre in Sinjai subdistrict.
Peningkatan Kualitas Pelayanan Administrasi Melalui Penyusunan Standar Pelayanan Di Kantor Desa Kalebentang Kecamatan Galesong Selatan Kabupaten Takalar
Authors: Asmarianti Asmarianti , Mubaraqah Muhammad Ikram
Published: March 2024

Pelayanan publik oleh birokrasi masih banyak menghadapi beberapa permasalahan seperti adanya calo, prosedur yang membingungkan, serta ketidakpastian terkait waktu dan biaya yang membuat akses pelayanan sangat sulit dan tidak merata bagi masyarakat. Penelitian ini bertujuan untuk menyusun Standar Pelayanan (SP) di Kantor Desa Kalebentang guna meningkatkan kualitas pelayanan kepada masyarakat. Metode yang diterapkan dalam penelitian ini ialah pendekatan kualitatif dengan mengumpulkan informasi melalui observasi, wawancara, studi dokumentasi, dan fokus grup diskusi (FGD). Hasil penelitian ini menghasilkan enam (6) Standar Pelayanan yang akan diterapkan di Kantor Desa Kalebentang, termasuk pelayanan Surat Keterangan Tidak Mampu (SKTM), Surat Pengantar Catatan Kepolisian, Surat Keterangan Usaha (SKU), Surat Pengantar Kartu Keluarga, Surat Pengantar Kartu Tanda Penduduk, dan Surat Keterangan Jual Beli Tanah. Setelah dilakukan kegiatan fokus grub diskusi (FGD) bersama aparat desa dan masyarakat, dilanjutkan pada tahap penetapan dan penerapan Standar Pelayanan dengan melakukan sosialisasi untuk memberikan pemahaman di lingkungan Kantor Desa Kalebentang, dan terakhir yaitu penetapan maklumat pelayanan yang berisi pernyataan kesanggupan para pelaksana untuk menjalankan pelayanan sesuai dengan Standar Pelayanan yang telah ditetapkan bersama.
Raw material economy. Oil boom in Galicia (the second half of the 19th – the first half of the 20th century)
Authors: Moshenskyi S.Z.
Published: March 2024

With the beginning of the oil era in the world, Galicia with its oil fields got a chance to take part in the processes of globalization, and foreign capital along with technological innovations flowed into this previously unknown region. And many new jobs appeared in the oil industry for those Galician peasants who wanted to change their lives. However, even during the biggest oil boom at the beginning of the 20th century, the economy of Galicia could not go beyond the closed circle of the resource raw material model. One of the first oil entrepreneurs was Ignatius Lukasevich, who invented a way to obtain kerosene from oil, which was used for lighting. And one of the most famous oil tycoons was Stanislav Shchepanovskyi, the author of books on the economy of Galicia. His enterprises were located in Sloboda Rungurska, which became one of the main centers of oil production along with Drohobych and Boryslav. Moisei Hartenberg from Drohobych became another oil tycoon. Galician Ukrainians were not leaders in the oil business, they owned about 10 % of the deposits, and the rest were transferred to foreigners after the beginning of the oil boom. In general, during the oil boom, more than three hundred joint-stock companies related to this industry were founded in Galicia. Most of these were small-scale, and 15 major companies accounted for three-quarters of all oil production. Large companies were created by foreign investors. After all, the profit from investments reached at the end of the 19th century 10–12 % (in Western Europe it did not exceed 3–4 % at the time) due to low wages, as well as intensive development of deposits to obtain maximum income in a short time. The maximum level of oil production was reached in 1909 – but only 5,2 % of the world (in the USA at that time – 63 %). In general, the oil reserves in Galicia were not very large, and after the First World War, when most of the oil wells were destroyed, they were no longer restored.
Tourist product in the segment of ecological tourism in Ukraine in today's conditions
Authors: Liubchenko V.V.
Published: March 2024

The article deals with the state of development of ecological tourism in Ukraine. The resource potential for the development of ecological tourism in Ukraine is highlighted and the competitive advantages of ecological tourism in Ukraine are highlighted. An overview of existing ecological tourism products in Ukraine was carried out and new promising places for the development of ecological tourism were identified. Proposals for improving the ecological tourism product were provided.

Ukraine has sufficient natural resources for the development of ecological tourism (ecotourism), which became popular among domestic tourists in the context of the COVID-19 pandemic and gained special importance with the beginning of a full-scale invasion of Ukraine by Russia in 2022. The main feature of ecological tourism is the obligation to preserve natural heritage and biological diversity, which is mercilessly destroyed by Russian aggression. 257 cases of ecocide, which causes irreparable damage to the environment in the long term, have been established.

When authoring the article, general scientific research methods and approaches were used: analysis, synthesis, induction, and deduction.
Exploring the Significance and Implementation Strategies of Mental Health Education for College Students
Authors: Xu Chang , Qu Xiaoyi , Yang Bining , Wang Kaidi
Published: March 2024

College students are influenced by diverse cultures in the new era, thus their inner world is rich and changingrapidly. The acceleration of social rhythm can easily lead to different kinds of psychological problems. Mental health education is people-oriented, using scientific methods and means to train high-quality talents with all-round development across the world. A healthy psychological state can promote the sound development of students, make them establish correct core social values, and realize self-value. At present, there are some problems in university mental health education, such as single form and imperfect system. At the same time, college education plays an important role in the formation of ideas for college students’ ideological values. As a front-line student worker, college counselors should cooperate with the school’s psychological departments to improve the college psychological education system, rationally plan the psychological teaching program, and pay attention to the college students’ mental health education. The government should also take into account the need to ensure that the education system is not undermined by the lack of a comprehensive and effective education system.
Cultivating Youth Interest in Badminton
Authors: Li Shunjiao
Published: March 2024

Conducting an investigation and analysis using literature review methods, the current state of interest cultivation among young badminton players was examined. The findings indicate a less optimistic situation regarding interest development among these young athletes: the initial interest motivation of young badminton players is significantly influenced by parents, with parental focus more on sporting achievements than the child’s happiness, neglecting the emotional well-being of children; coaches prioritize fundamental technical skills over interest cultivation, and the methods used to stimulate interest still exhibit traditional tendencies, overlooking the application of game-based and competitive approaches; there is a lack of practical implementation in interest cultivation; the majority of coaches create an unfavorable classroom atmosphere, easily overlooking students’ emotional experiences. Understanding the current development status and trends in interest cultivation for youth badminton, this study analyzed data on interest cultivation methods. It wasfound that the majority of badminton teaching tends to focus on scientific technical training and physical fitness for young players. While many coaches and parents express affirmation for interest cultivation methods, they are not widely applied in practice at present. Incorporating game-based teaching into badminton instruction has the potential to enhance students’ interest in badminton learning, especially for novice young players, facilitating the early establishment of a love for badminton.
The Effectiveness of Peer Feedback on Second Language Writing
Authors: Chen Yijun
Published: March 2024

Peer feedback is a widely utilized practice in writing classrooms for second languages (L2) that has drawna lot of attention. While some support the practice because of the clear advantages that peer feedback offers students, others doubt its efficacy. Comparing various forms of feedback is therefore necessary, as is determining the effects that peer feedback has on students and the variables that might affect how successful peer feedback is. This paper focuses on the usefulness of peer feedback for L2 writing, based on a review of studies on the subject. The findings imply that the functions of peer and teacher feedback are distinct, and that peer feedback is advantageous to both parties, particularly to the supplier. The attitudes and cultural backgrounds of the students are among the other factors that affect how effective peer feedback is. Lastly, some implications for future research and education are presented.
Research on the Course of Principles of Concrete Structure Design
Authors: Shi Yuhuan , Hu Jinping , Lin Xue , Jiang Zhinan , Qi Jialian
Published: March 2024

Nowadays, education and teaching have become a hot topic, and teaching in colleges and universities is facinga brand-new development direction. Principles of Concrete Structure Design, as one of the main courses, transmits professional knowledge for students, enhances the students’ professional ability, and further carries out in-depth research on the course to bring a better teaching effect for students. The article mainly focuses on the research of the principles of concrete structure design course, conducts an analysis of the teaching characteristics of the principles of concrete structure design course, and reasonably sets the teaching content from the optimization of the course teaching objectives; innovative course teaching methods can deepen the effect of knowledge understanding; reform of experimental practice teaching can lay down the effect of the internalization of knowledge, etc. The in-depth description and discussion of the relevant aspects of the research aim to provide guidelines for related research.