bluuebunny/crossref_metadata_2025 huggingface dataset:
Nurses’ rationale for underreporting of patient and visitor perpetrated workplace violence: a systematic review
Authors: Spencer Cara , Sitarz Jamie , Fouse June , DeSanto Kristen
Published: April 2023

Background

Patient and visitor perpetrated workplace violence (WPV) is a problem within healthcare and is known to be underreported by nurses and other healthcare workers. However, there are multiple and diverse reasons identified in the literature as to why nurses do not report. This systematic review aimed to investigate nurses’ reasons and rationale related to underreporting of violence that occurs in the workplace.

Methods

Following PRISMA guidelines for systematic review reporting, studies conducted between 2011 and early 2022 were identified from MEDLINE, CINAHL, APA PsychInfo, and Psychological and Behavioral Sciences Collection via EBSCOHost. Quantitative studies related to patient and visitor perpetrated violence containing explanations, reasons, or rationale related to underreporting were included.

Results

After quality appraisals, 19 studies representing 16 countries were included. The resulting categories identified nursing, management, and organizational factors. The most prominent nursing factors included nurses’ fear of consequences after reporting, nurses’ perceptions, and their lack of knowledge about the reporting process. Common management factors which contributed to nursing underreporting included lack of visible changes after reporting, non-supportive culture in which to report, and the lack of penalties for perpetrators. Organizational factors included the lack of policies/procedures/training for WPV, as well as a lack of an efficient and user-friendly reporting system. Supportive interventions from management, organizations, and community sources were summarized to provide insight to improve nurse reporting of WPV events.

Conclusion

Underreporting of WPV is a complex and multi-faceted problem. An investigation into the rationale for underreporting a workplace violent event illustrates nurses, management, and organizations contribute to the problem. Clear and actionable interventions such as educational support for staff and the development of a clear and concise reporting processes are recommended to encourage staff reporting and to help address WPV in healthcare.
Effects of BOPPPS combined with TBL in surgical nursing for nursing undergraduates: a mixed-method study
Authors: Li Zhiying , Cai Xiaoyan , Zhou Kebing , Qin Jieying , Zhang Jiahui , Yang Qiaohong , Yan Fengxia
Published: April 2023

Background

Surgical Nursing is a core subject for nursing undergraduates that requires active and effective learning strategies to cultivate students’ autonomous learning competencies and critical thinking. The effects of BOPPPS (Bridge-in, Objectives, Pretest, Participatory Learning, Post-test and Summary) model combined with team-based learning (TBL) have rarely been explored in Surgical Nursing courses.

Objective

To explore the effects of BOPPPS combined with TBL in Surgical Nursing for nursing undergraduates.

Methods

A mixed research method of quasi-experimental study design and descriptive qualitative research was used. The control group included 27 nursing undergraduates who had finished the Surgical Nursing course using traditional learning. The experimental group included 36 nursing undergraduates were enrolled in to receive the Surgical Nursing course in the teaching mode of BOPPPS combined with TBL. The quantitative data of students’ Surgical Nursing final scores, autonomous learning competencies and critical thinking ability of the two groups were collected and compared by t-test. Qualitative results were obtained through semi-structured interviews and data were analyzed by thematic analysis method.

Results

Compared with the traditional learning mode, BOPPPS combined with TBL significantly improved nursing students’ final examination scores, autonomous learning competencies and critical thinking ability (p < 0.05). Qualitative results from 14 undergraduate nursing students’ interviews were summarized into five themes: (1) stimulating learning interest; (2) improving autonomous learning ability; (3) improving the sense of teamwork; (4) exercising critical thinking; and (5) suggestions for improvement.

Conclusions

The combination of BOPPPS and TBL positively impacted nursing students by improving their autonomous learning competencies and critical thinking ability. The study suggests BOPPPS combined with TBL learning as an effective, alternative learning mode.
Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss
Authors: Yoon Dong Suk , Choi Yoorim , Lee Kyoung-Mi , Ko Eun Ae , Kim Eun-Ji , Park Kwang Hwan , Lee Jin Woo
Published: April 2023

Background

Although mRNA dysregulation can induce changes in mesenchymal stem cell (MSC) homeostasis, the mechanisms by which post-transcriptional regulation influences MSC differentiation potential remain understudied. PUMILIO2 (PUM2) represses translation by binding target mRNAs in a sequence-specific manner.

Methods

In vitro osteogenic differentiation assays were conducted using human bone marrow-derived MSCs. Alkaline phosphatase and alizarin red S staining were used to evaluate the osteogenic potential of MSCs. A rat xenograft model featuring a calvarial defect to examine effects of MSC-driven bone regeneration. RNA-immunoprecipitation (RNA-IP) assay was used to determine the interaction between PUM2 protein and Distal-Less Homeobox 5 (DLX5) mRNA. Ovariectomized (OVX) mice were employed to evaluate the effect of gene therapy for postmenopausal osteoporosis.

Results

Here, we elucidated the molecular mechanism of PUM2 in MSC osteogenesis and evaluated the applicability of PUM2 knockdown (KD) as a potential cell-based or gene therapy. PUM2 level was downregulated during MSC osteogenic differentiation, and PUM2 KD enhanced MSC osteogenic potential. Following PUM2 KD, MSCs were transplanted onto calvarial defects in 12-week-old rats; after 8 weeks, transplanted MSCs promoted bone regeneration. PUM2 KD upregulated the expression of DLX5 mRNA and protein and the reporter activity of its 3'-untranslated region. RNA-IP revealed direct binding of PUM2 to DLX5 mRNA. We then evaluated the potential of adeno-associated virus serotype 9 (AAV9)-siPum2 as a gene therapy for osteoporosis in OVX mice.

Conclusion

Our findings suggest a novel role for PUM2 in MSC osteogenesis and highlight the potential of PUM2 KD-MSCs in bone regeneration. Additionally, we showed that AAV9-siPum2 is a potential gene therapy for osteoporosis.
Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking
Authors: Gleave Katherine , Guy Amy , Mechan Frank , Emery Mischa , Murphy Annabel , Voloshin Vitaly , Towers Catherine E. , Towers David , Ranson Hilary , Foster Geraldine M. , McCall Philip J.
Published: April 2023

Background

The success of insecticide treated bed nets (ITNs) for malaria vector control in Africa relies on the behaviour of various species of Anopheles. Previous research has described mosquito behavioural alterations resulting from widespread ITN coverage, which could result in a decrease in net efficacy. Here, behaviours were compared including timings of net contact, willingness to refeed and longevity post-exposure to two next-generation nets, PermaNet® 3.0 (P3 net) and Interceptor® G2 (IG2 net) in comparison with a standard pyrethroid-only net (Olyset Net™ (OL net)) and an untreated net.

Methods

Susceptible and resistant Anopheles gambiae mosquitoes were exposed to the nets with a human volunteer host in a room-scale assay. Mosquito movements were tracked for 2 h using an infrared video system, collecting flight trajectory, spatial position and net contact data. Post-assay, mosquitoes were monitored for a range of sublethal insecticide effects.

Results

Mosquito net contact was focused predominantly on the roof for all four bed nets. A steep decay in activity was observed for both susceptible strains when P3 net and OL net were present and with IG2 net for one of the two susceptible strains. Total mosquito activity was higher around untreated nets than ITNs. There was no difference in total activity, the number, or duration, of net contact, between any mosquito strain, with similar behaviours recorded in susceptible and resistant strains at all ITNs. OL net, P3 net and IG2 net all killed over 90% of susceptible mosquitoes 24 h after exposure, but this effect was not seen with resistant mosquitoes where mortality ranged from 16 to 72%. All treated nets reduced the willingness of resistant strains to re-feed when offered blood 1-h post-exposure, with a more pronounced effect seen with P3 net and OL net than IG2 net.

Conclusion

These are the first results to provide an in-depth description of the behaviour of susceptible and resistant Anopheles gambiae strains around next-generation bed nets using a room-scale tracking system to capture multiple behaviours. These results indicate that there is no major difference in behavioural responses between mosquito strains of differing pyrethroid susceptibility when exposed to these new ITNs under the experimental conditions used.
The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma
Authors: Chen Mengke , Fang Yi , Liang Meinong , Zhang Ning , Zhang Xinyue , Xu Lixia , Ren Xuxin , Zhang Qingfeng , Zhou Yufeng , Peng Sui , Yu Jun , Zeng Judeng , Li Xiaoxing
Published: April 2023

Background

Both dysregulation of mechanistic target of rapamycin (mTOR) signalling and DNA methylation patterns have been shown to be closely associated with tumor progression and serve as promising targets for hepatocellular carcinoma (HCC) therapy. Although their respective roles in HCC have been extensively revealed, the existence of molecular interactions between them remains largely unknown.

Methods

The association of DNA methylation and mTOR signalling in HCC tissues and cell lines was assessed. A Kaplan‒Meier analysis was applied to estimate the overall survival (OS) and recurrence-free survival (RFS) of HCC patients. The modulation of DNMT1 by mTOR in HCC cell lines was determined. The effect of the drug combination in cell lines and mouse models was examined.

Results

The results showed that the DNA methylation level was positively associated with the activation of mTOR signalling in HCC tissues and cell lines. Moreover, HCC patients with higher DNA methylation levels and enhanced activation of mTOR signalling exhibited the worst prognosis. Then, we screened methylation-related enzymes and found that the activation of mTOR signalling increased DNMT1 expression and activity. In addition, mTOR enhanced the translational efficiency of DNMT1 in a 4E-BP1-dependent manner, which is based on the pyrimidine rich translational element (PRTE)-containing 5′UTR of DNMT1. Moreover, we demonstrated that the combined inhibition of mTOR and DNMT synergistically inhibited HCC growth in vitro and in vivo.

Conclusions

In addition to some already identified pro-cancer downstream molecules, the activation of mTOR signalling was found to promote DNA methylation by increasing the translation of DNMT1. Furthermore, combined targeting of mTOR and DNMT1 has been demonstrated to have a more effective tumor suppressive function in HCC.
Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats
Authors: Cary Chelsea M , Seymore Talia N , Singh Dilpreet , Vayas Kinal N , Goedken Michael J , Adams Samantha , Polunas Marianne , Sunil Vasanthi R , Laskin Debra L , Demokritou Philip , Stapleton Phoebe A
Published: April 2023

Background

Exposure to micro- and nanoplastic particles (MNPs) in humans is being identified in both the indoor and outdoor environment. Detection of these materials in the air has made inhalation exposure to MNPs a major cause for concern. One type of plastic polymer found in indoor and outdoor settings is polyamide, often referred to as nylon. Inhalation of combustion-derived, metallic, and carbonaceous aerosols generate pulmonary inflammation, cardiovascular dysfunction, and systemic inflammation. Additionally, due to the additives present in plastics, MNPs may act as endocrine disruptors. Currently there is limited knowledge on potential health effects caused by polyamide or general MNP inhalation.

Objective

The purpose of this study is to assess the toxicological consequences of a single inhalation exposure of female rats to polyamide MNP during estrus by means of aerosolization of MNP.

Methods

Bulk polyamide powder (i.e., nylon) served as a representative MNP. Polyamide aerosolization was characterized using particle sizers, cascade impactors, and aerosol samplers. Multiple-Path Particle Dosimetry (MPPD) modeling was used to evaluate pulmonary deposition of MNPs. Pulmonary inflammation was assessed by bronchoalveolar lavage (BAL) cell content and H&E-stained tissue sections. Mean arterial pressure (MAP), wire myography of the aorta and uterine artery, and pressure myography of the radial artery was used to assess cardiovascular function. Systemic inflammation and endocrine disruption were quantified by measurement of proinflammatory cytokines and reproductive hormones.

Results

Our aerosolization exposure platform was found to generate particles within the micro- and nano-size ranges (thereby constituting MNPs). Inhaled particles were predicted to deposit in all regions of the lung; no overt pulmonary inflammation was observed. Conversely, increased blood pressure and impaired dilation in the uterine vasculature was noted while aortic vascular reactivity was unaffected. Inhalation of MNPs resulted in systemic inflammation as measured by increased plasma levels of IL-6. Decreased levels of 17β-estradiol were also observed suggesting that MNPs have endocrine disrupting activity.

Conclusions

These data demonstrate aerosolization of MNPs in our inhalation exposure platform. Inhaled MNP aerosols were found to alter inflammatory, cardiovascular, and endocrine activity. These novel findings will contribute to a better understanding of inhaled plastic particle toxicity.
Triggers of self-focused attention: an ecological momentary assessment study
Authors: Nanamori Mao , Tomita Nozomi , Kametani Chiaki , Matsuda Naomi , Kumano Hiroaki
Published: April 2023

Background

Self-focused attention (SFA) is a major maintenance factor of social anxiety disorder. The two types of SFA, the observer perspective and self-focus on body sensation, increase anxiety in individuals with high levels of social anxiety. However, the triggers of each SFA remain unclear. This study used ecological momentary assessment to identify the factors that elicit SFA in real-life social scenarios.

Methods

The study obtained 316 samples from 22 Japanese university students (4 male:18 female) with high social anxiety who completed momentary measures of stimulus perception and two types of SFA for 10 days. Links to online questionnaires were sent to the participants via e-mails 3 times a day. First, multilevel single regression analyses were used to identify the stimuli that induced the two types of SFA. Between-level interaction with gender was done to determine the effect of gender biasing on the female participants. Next, for the variables that were significantly predictive in these analyses, multilevel multiple regression analyses were conducted with fear of each stimulus as a control variable.

Results

Perception of gaze, evaluation, and authority predicted SFA from the observer perspective. Perception of gaze also predicted self-focus on body sensation. In addition, the perception of positive response and that of stranger predicted self-focus on body sensation depended on gender, implying that the positive response perception of female participants predicted self-focus on body sensation. After controlling for corresponding fear, gaze perception predicted both SFAs, and the perception of authority predicted SFA from the observer perspective. In addition, after controlling for relevant fear, the perception of positive response of female participants predicted self-focus on body sensation. In contrast, the fear of evaluation but not the perception of evaluation predicted SFA from the observer perspective.

Conclusions

The perception of gaze is the most powerful trigger of the two types of SFA, even after controlling for fear of gaze in real-life social scenarios for individuals with social anxiety. SFA from the observer perspective is also triggered by the perception of authority and fear of evaluation. The role of perception of positive responses or strangers should be re-evaluated after correcting for gender imbalance. (350 words / 350 words)
IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism
Authors: Liu Tian-yue , Hu Chen-chen , Han Chen-ying , Mao Si-yi , Zhang Wen-xin , Xu Yi-ming , Sun Yuan-jie , Jiang Dong-bo , Zhang Xi-yang , Zhang Jia-xing , Wang Jing , Qiao Xu-peng , Pan Jing-yu , Yang Shu-ya , Yang Kun
Published: April 2023

Background

Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, ranking third for morbidity and mortality worldwide. At present, no effective control method is available for this cancer type. In tumor cells, especially iron metabolization, is necessary for its growth and proliferation. High levels of iron are an important feature to maintain tumor growth; however, the overall mechanism remains unclear.

Methods

We used western blotting, immunohistochemistry (IHC) and real-time quantitative PCR to analyze the expression of IGF2BP2 in cell lines and tissues. Further, RNA-sequencing, RNA immunoprecipitation and methylated RNA immunoprecipitation experiments explored the specific binding of target genes. Moreover, the RNA stability assay was performed to determine the half-life of genes downstream of IGF2BP2. In addition, the Cell Counting Kit-8, colony formation assay, 5-ethynyl-2’-deoxyuridine assay and flow cytometry were used to evaluate the effects of IGF2BP2 on proliferation and iron metabolism. Lastly, the role of IGF2BP2 in promoting CRC growth was demonstrated in animal models.

Results

We observed that IGF2BP2 is associated with iron homeostasis and that TFRC is a downstream target of IGF2BP2. Further, overexpression of TFRC can rescue the growth of IGF2BP2-knockdown CRC cells. Mechanistically, we determined that IGF2BP2 regulates TFRC methylation via METTL4, thereby regulating iron metabolism and promoting CRC growth. Furthermore, using animal models, we observed that IGF2BP2 promotes CRC growth.

Conclusion

IGF2BP2 regulates TFRC mRNA methylation via METTL4, thereby regulating iron metabolism and promoting CRC growth. Our study highlights the key roles of IGF2BP2 in CRC carcinogenesis and the iron transport pathways.
Consensus on the management of united airways disease with type 2 inflammation: a multidisciplinary Delphi study
Authors: Blanco-Aparicio Marina , Domínguez-Ortega Javier , Cisneros Carolina , Colás Carlos , Casas Francisco , del Cuvillo Alfonso , Alobid Isam , Quirce Santiago , Mullol Joaquim
Published: April 2023

Background

Scientific evidence on patients with multimorbid type 2 asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) from a united airways disease (UAD) perspective remains scarce, despite the frequent coexistence of these entities. We aimed to generate expert consensus-based recommendations for the management of UAD patients.

Methods

Using a two-round Delphi method, Spanish expert allergists, pulmonologists and otolaryngologists expressed their agreement on 32 statements (52 items) on a 9-point Likert scale, classified as appropriate (median 7–9), uncertain (4–6) or inappropriate (1–3). Consensus was considered when at least two-thirds of the panel scored within the range containing the median.

Results

A panel of 30 experts reached consensus on the appropriateness of 43 out of the 52 (82.7%) items. The usefulness of certain biomarkers (tissue and peripheral blood eosinophil count, serum total IgE, and fraction of exhaled nitric oxide [FeNO]) in the identification and follow-up of type 2 inflammation, and assessment of the response to biologics, were agreed. Some of these biomarkers were also associated with disease severity and/or recurrence after endoscopic sinus surgery (ESS). Consensus was achieved on treatment strategies related to the prescription of anti-IL-4/IL-13 or anti-IgE agents, concomitant treatment with systemic corticosteroids, and combining or switching to biologics with a different mechanism of action, considering a number of UAD clinical scenarios.

Conclusion

We provide expert-based recommendations to assist in clinical decision-making for the management of patients with multimorbid type 2 asthma and CRSwNP. Specific clinical trials and real-world studies focusing on the single-entity UAD are required to address controversial items.
Parental alienation in Lebanon: a case report
Authors: Fares Rabih , Najem Roudna , Hallit Souheil , Pelissolo Antoine , Haddad Georges , Naja Wadih J.
Published: April 2023

Background

Parental alienation is a relatively newly described disorder, with a growing prevalence, as divorce and custody battles are becoming more and more complex with increased difficulty of joint custody. In parental alienation, one parent, the alienating parent, forms an alliance with the child involved in the custody dispute and manages to effectively alienate the targeted parent completely. The child and the alienating parent manifest a form of folie à deux and, hence, are in complete synchrony in the hatred and denigration of the targeted parent. Issues, such as potentially false allegations of sexual, physical, and emotional abuse of the child by the targeted parent, arise. The child and the alienating parent become mutually convinced of the targeted parent’s transgressions. Consequently, it becomes difficult for the courts and psychiatric professionals to differentiate true abuse from parental alienation.

Case presentation

In this case study, we aimed to conduct an in-depth psychological and psychiatric evaluation of a Lebanese family (white race) where a father was wrongly accused by the mother and his 11-year-old white boy of both physical and sexual abuse. The data for this study were collected through unstructured and semi-structured interviews, observations, and psychological tests (Rorschach test for the parents and Blacky test for the child), and through the analysis of documented evidence presented in the trial.

Conclusion

This case manifested most criteria set forth for the diagnosis of parental alienation and created serious doubt regarding the validity of the allegations set forth by the mother and the child. Uncovered parental alienation often misleads mental health professionals at the expense of the child’s mental health .
In-silico target prediction by ensemble chemogenomic model based on multi-scale information of chemical structures and protein sequences
Authors: Yang Su-Qing , Zhang Liu-Xia , Ge You-Jin , Zhang Jin-Wei , Hu Jian-Xin , Shen Cheng-Ying , Lu Ai-Ping , Hou Ting-Jun , Cao Dong-Sheng
Published: April 2023

Identification and validation of bioactive small-molecule targets is a significant challenge in drug discovery. In recent years, various in-silico approaches have been proposed to expedite time- and resource-consuming experiments for target detection. Herein, we developed several chemogenomic models for target prediction based on multi-scale information of chemical structures and protein sequences. By combining the information of a compound with multiple protein targets together and putting these compound-target pairs into a well-established model, the scores to indicate whether there are interactions between compounds and targets can be derived, and thus a target prediction task can be completed by sorting the outputted scores. To improve the prediction performance, we constructed several chemogenomic models using multi-scale information of chemical structures and protein sequences, and the ensemble model with the best performance was used as our final model. The model was validated by various strategies and external datasets and the promising target prediction capability of the model, i.e., the fraction of known targets identified in the top-k (1 to 10) list of the potential target candidates suggested by the model, was confirmed. Compared with multiple state-of-art target prediction methods, our model showed equivalent or better predictive ability in terms of the top-k predictions. It is expected that our method can be utilized as a powerful computational tool to narrow down the potential targets for experimental testing.

Graphical Abstract
Loss of Stat3 in Osterix+ cells impairs dental hard tissues development
Authors: Chan Laiting , Lu Jiarui , Feng Xin , Lin Lichieh , Yao Yichen , Zhang Xiaolei
Published: April 2023

Background

Mutations in the signal transducers and activators of transcription 3 (STAT3) gene result in hyper-IgE syndrome(HIES), a rare immunodeficiency that causes abnormalities in immune system, bones and teeth. However, the role of Stat3 in development of dental hard tissues was yet to investigate.

Methods

In this study, a transgenic mouse of conditional knockout of Stat3 in dental mesenchymal cells (Osx-Cre; Stat3fl/fl, Stat3 CKO) was made. The differences of postnatal tooth development between control and Stat3 CKO mice were compared by histology, µCT and scanning electron microscopy.

Result

Compared with the control, Stat3 CKO mice were presented with remarkable abnormal tooth phenotypes characterized by short root and thin dentin in molars and incisors. The enamel defects were also found on mandibular incisors. showed that Ki67-positive cells significantly decreased in dental mesenchymal of Stat3 CKO mice. In addition, β-catenin signaling was reduced in Hertwig's epithelial root sheath (HERS) and odontoblasts of Stat3 CKO mice.

Conclusions

Our results suggested that Stat3 played an important role in dental hard tissues development, and Stat3 may regulate dentin and tooth root development through the β-catenin signaling pathway.
Perceived barriers to seeking treatment for alcohol use disorders among the general Danish population – a cross sectional study on the role of severity of alcohol use and gender
Authors: Finn Sara Wallhed , Mejldal Anna , Nielsen Anette Søgaard
Published: April 2023

Background

A minority of all individuals with alcohol use disorders (AUD) seek treatment. Since the suffering from AUD has severe consequences for both the individual and for society, it is important to improve the understanding of barriers to seeking treatment. Most studies of barriers thus far have been conducted in the United States of America or the United Kingdom. There is a need for studies from other contexts. The overall aim is to investigate barriers to treatment seeking for AUD. The specific aims are to: 1) describe barriers to AUD treatment at different levels of alcohol use. 2) compare gender differences regarding barriers to AUD treatment.

Methods

Study design: Cross-sectional. Participants: 1594 representative Danish adults from the general population aged 30–65 years. An online questionnaire was administrated by a market research company. The questionnaire covered demographic data, barriers to treatment and level of alcohol use. Analyses were performed by means of chi-2 test and logistic regression.

Results

The most common barriers were related to stigma and shame: admitting to others of having a problem, being labelled, fear of the consequences and that others would find out. Participants with higher severity of alcohol use were more likely to endorse a wish to handle alcohol problems themselves and to report barriers related to treatment services. Women with high severity of alcohol use, endorsed higher level of fear of the consequences than men.

Conclusions

There is an urgent need to reduce stigma around AUD. Individuals with higher severity of alcohol use report a lower willingness to seek professional treatment if a problem occurs. Especially among individuals with high severity of alcohol use there is a need to address gender specific barriers.
Properties of Concrete and Structural Behaviour of Reinforced Concrete Beam Containing Shredded Waste Paper as An Additive
Authors: Solahuddin B. A. , Yahaya F. M.
Published: April 2023

This research uses WP to investigate the effect of two types of Shredded Waste Paper (SWP) comprising Shredded Copier Waste Paper (SCPWP) and Shredded Cardboard Waste Paper (SCBWP) as additives on the properties of concrete and the structural behaviour of Reinforced Concrete Beam (RCB). The slump, compressive, flexural, and splitting tensile strengths increase by 4–13% for 5–10% addition of SCPWP and decrease by 16–23% for 15% addition of SCPWP compared to 0% addition. For SCBWP, the slump, compressive, flexural and splitting tensile strengths increase by 10–23% for 5–10% addition and decrease by 15–21% for 15% addition compared to 0% addition. 15% of SCPWP and SCBWP addition records the highest effect in water absorption and efflorescence, showing 11% and 10.28% increases with 15% addition of SCBWP and SCPWP. Scanning electron microscope (SEM) analysis reveals that the crack is repaired, and the presence of calcium hydroxide (Ca(OH)2) and calcium–silicate–hydrate (C–S–H) links enhances the concrete strength. The addition of 10% SCPWP and 10% SCBWP in the concrete mixtures improves the structural behaviour of RCB with stirrup spacing (SS) = 100 mm (full), 150 mm and 200 mm (reduced) by increasing the load and reducing the deflection. Apart from that, the concrete bending and shear strains also increase by 44.17% and 34.9%. The failure mode of the RCB changes from shear to bending. This study indicates that SCPWP and SCBWP can be used as additives in concrete at 5% and 10%, and 10% for RCB with significant strength and structural improvement.
Comparison of LSM indexing techniques for storing spatial data
Authors: Mao Qizhong , Qader Mohiuddin Abdul , Hristidis Vagelis
Published: April 2023

In the pre-big data era, many traditional databases supported spatial queries via spatial indexes. However, modern applications are seeing a rapid increase of the volume and ingestion rate of spatial data. Log-structured Merge (LSM) tree is used by many big data systems as their storage structure in order to support write-intensive large-volume workloads, which are usually only optimized for single-dimensional data. Research has studied how spatial indexes can be supported on LSM systems, but focused mainly on the local index organization, that is, how data is organized inside a single LSM component. This paper studies various aspects of LSM spatial indexing, including spatial merge policies, which determine when and how spatial components are merged. Three stack-based and one leveled merge policies have been studied, which have been implemented on a common big data system Apache AsterixDB. The write and read performance on various workloads is evaluated, and our findings and recommendations are discussed. A key finding is that Leveled policies underperform other stack-based merge policies for most types of spatial workloads.
Longitudinal structures of zonal wind in the thermosphere by the ICON/MIGHTI and the main wave sources
Authors: Li Dan , Gao Hong , Xu Jiyao , Zhu Yajun , Xu Qiuyu , Liu Yangkun , Liu Hongshan
Published: April 2023

In this study, the neutral wind observations from the Michelson Interferometer for Global High-resolution Thermospheric Imaging (MIGHTI) instrument onboard Ionospheric CONnections (ICON) are used to investigate the longitudinal structure of zonal wind between 100 and 300 km during daytime. The four-peaked structure in the longitudinal distribution between June and August is visually clear in the whole altitudinal range. The longitudinal wavenumber 1–4 patterns (WN1–WN4) are extracted, and the altitude–month distributions of WN1–WN4 and their contributions to the longitudinal structure are compared. The amplitudes of WN3 and WN4 show seasonal dependence, and the amplitude of WN4 exhibits obvious vertical propagation from the mesosphere and lower thermosphere (MLT) to the upper thermosphere in summer and autumn. WN1 is an important contributor to the longitudinal structure, WN4 is the primary contributor in the lower altitude ranges in summer and autumn at three latitudes. The contributions of WN3 (WN1) increase holistically with latitude in summer (spring, autumn, and winter). And the main wave sources of WN1–WN4 are further investigated in the 100–106 km and 210–300 km altitude regions. The main wave sources of WN1 and WN2 have complex variations with altitude, latitude, and season, while WN3 (WN4) is clearly influenced by DE2 (DE3 and SE2).

Graphical Abstract
Strong ground motion simulations of the 2016 Kumamoto earthquakes using corrected empirical Green’s functions: methods and results for ESG6 blind prediction Steps 2 and 3 with improved parameters
Authors: Nagasaka Yosuke
Published: April 2023

This paper describes the methods and results of the strong ground motion simulations for three earthquakes from the 2016 Kumamoto earthquake sequence using corrected empirical Green’s functions. The target earthquakes were an aftershock (Mw 5.5), the largest foreshock of the sequence (Mw 6.1), and the mainshock (Mw 7.1). The corrected empirical Green’s function method was used in the simulations. This simulation method combines simple source and path factors with empirical site amplification and phase factors to generate realistic site-specific strong motions. Simulations were originally conducted to participate in blind prediction exercises in ESG6. Although the simulations performed in this study were based on the models submitted to the blind prediction committee, several modifications were made after the blind prediction exercise. First, the observed records at the target site of the blind prediction called KUMA were used to compare observed and synthetic strong ground motions. In addition, a regional spectral inversion was conducted to obtain a more appropriate Q-value and site amplification factor. Synthetic strong motions were found to explain the observed strong ground motions at KUMA and other stations. Comparisons with predictions by other methods and the sensitivity to the rupture scenario were also discussed. These results provide useful information for applying the corrected Green’s function method to strong ground motion simulations.

Graphical Abstract
Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: a systematic review and meta-analysis
Authors: Minkove Samuel , Dhamapurkar Rhea , Cui Xizhong , Li Yan , Sun Junfeng , Cooper Diane , Eichacker Peter Q. , Torabi-Parizi Parizad
Published: April 2023

Background

Extensive animal investigation informed clinical practice regarding the harmful effects of high fractional inspired oxygen concentrations (FiO2s > 0.60). Since questions persist whether lower but still supraphysiologic FiO2 ≤ 0.60 and > 0.21 (FiO2 ≤ 0.60/ > 0.21) are also harmful with inflammatory lung injury in patients, we performed a systematic review examining this question in animal models.

Methods

Studies retrieved from systematic literature searches of three databases, that compared the effects of exposure to FiO2 ≤ 0.60/ > 0.21 vs. FiO2 = 0.21 for ≥ 24 h in adult in vivo animal models including an inflammatory challenge or not were analyzed. Survival, body weight and/or lung injury measures were included in meta-analysis if reported in ≥ 3 studies.

Results

More than 600 retrieved reports investigated only FiO2s > 0.60 and were not analyzed. Ten studies with an inflammatory challenge (6 infectious and 4 noninfectious) and 14 studies without, investigated FiO2s ≤ 0.60/ > 0.21 and were analyzed separately. In seven studies with an inflammatory challenge, compared to FiO2 = 0.21, FiO2 ≤ 0.60/ > 0.21 had consistent effects across animal types on the overall odds ratio of survival (95%CI) that was on the side of harm but not significant [0.68 (0.38,1.23), p = 0.21; I2 = 0%, p = 0.57]. However, oxygen exposure times were only 1d in 4 studies and 2–4d in another. In a trend approaching significance, FiO2 ≤ 0.60/ > 0.21 with an inflammatory challenge consistently increased the standardized mean difference (95%CI) (SMD) in lung weights [0.47 (− 0.07,1.00), p = 0.09; I2 = 0%, p = 0.50; n = 4 studies] but had inconsistent effects on lung lavage protein concentrations (n = 3), lung pathology scores (n = 4) and/or arterial oxygenation (n = 4) (I2 ≥ 43%, p ≤ 0.17). Studies without an inflammatory challenge had consistent effects on lung lavage protein concentration (n = 3) SMDs on the side of being increased that was not significant [0.43 (− 0.23,1.09), p = 0.20; I2 = 0%, p = 0.40] but had inconsistent effects on body and lung weights (n = 6 and 8 studies, respectively) (I2 ≥ 71%, p < 0.01). Quality of evidence for studies was weak.

Interpretation

Limited animal studies have investigated FiO2 ≤ 0.60/ > 0.21 with clinically relevant models and endpoints but suggest even these lower FiO2s may be injurious. Given the influence animal studies examining FiO2 > 0.60 have had on clinical practice, additional ones investigating FiO2 ≤ 0.60/ > 0.21 appear warranted, particularly in pneumonia models.
Prepancreatic postduodenal portal vein: a case report and literature review
Authors: Akashi Masanori , Miyazaki Daiki , Hashimoto Kazuaki , Fukutomi Shogo , Arai Shoichiro , Goto Yuichi , Sato Toshihiro , Sakai Hisamune , Hisaka Toru
Published: April 2023

Background

Among congenital anomalies of the portal venous system, prepancreatic postduodenal portal vein (PPPV) is very rare and has only been reported to date. Herein, we report a case of PPPV identified in preoperative examinations for hepatocellular carcinoma and a literature review.

Case presentation

A 63-year-old man was admitted to our hospital for treatment of a liver tumor. After examination, he was diagnosed with hepatocellular carcinoma with a diameter of 40 mm in segment 8. Contrast-enhanced computed tomography scan showed a portal vein passing between the duodenum and pancreas, hence called PPPV. At the hepatic hilus, the portal vein branched off in a complicated course with some porto-portal communications. We determined that anatomical resection with manipulation of the hepatic hilum in this case resulted in major vascular injury. Therefore, we performed partial liver resection, and the patient was discharged uneventfully on postoperative day 14.

Conclusions

Although PPPV is an extremely rare congenital vascular variant, it is important to carefully identify vascular patterns preoperatively and to recognize the possibility of such an anomaly to avoid misidentification and inadvertent injuries during surgery.
Six-month stability following extensive alveolar bone augmentation by sausage technique
Authors: Kim Kang-min , Choi Soo-young , Park Jung-Hyun , Kim Heon-Young , Kim Sun-Jong , Kim Jin-Woo
Published: April 2023

Background

Resorption of alveolar bone is a common sequela of tooth loss and presents a clinical problem, especially in the esthetic zone. When ridge resorption occurs, adequate bone augmentation is essential to obtain satisfactory esthetic results. The purpose of this study was to determine the increase and retention rate of bone height or width in patients who received extensive bone augmentation and to analyze factors affecting its prognosis and stability.

Methods

This study was performed on patients who received extensive bone augmentation by sausage technique at the Department of Oral and Maxillofacial Surgery at Ewha Womans University Mok-dong Hospital from January 1, 2018, to February 28, 2022. CBCT images were taken before and 6 months after surgery to compare the amount of increase in bone height or width at the graft site. They were measured using reliable points such as adjacent implants or cephalometric landmarks, inferior alveolar nerve canals as reference points.

Results

A total of 8 patients underwent extensive bone grafting during the given period (mean age was 53.75 years, 2 males and 6 females). Four patients received horizontal augmentation, and 4 received vertical augmentation. When divided by surgical site, 4 patients are in maxilla and 4 in mandible. The average amount of increase in bone width or bone height was 5.38 mm, and the retention rate was about 79.9% after 6 months. The retention rate of horizontal augmentation was 88.8%, which was higher than that of vertical augmentation, which was 74.5%. The maxillary area accounted for 92.2%, and the amount of bone resorption was lower than that of the mandibular area, which was 72.6%. The average stitch out period was about 2.4 weeks, and postoperative dehiscence was observed about 37.5% of the total, more frequently in the mandible (50.0%) than in the maxilla (25.0%).

Conclusion

In conclusion, extensive bone augmentation achieved significant horizontal or vertical bone height or width increase, and the retention rate after 6 months was also high. In addition, surgery in the maxillary region showed a more successful bone augmentation than in the mandible, with a higher maintenance rate and fewer cases of dehiscence.
A holistic view of maritime navigation accidents and risk indicators: examining IMO reports from 2011 to 2021
Authors: Dominguez-Péry Carine , Tassabehji Rana , Corset Franck , Chreim Zainab
Published: April 2023

This paper investigated the risk indicators in maritime accidents and how they are considered within the reporting of maritime accidents, drawing on ten years of International Maritime Organisation (IMO) (2011–2020) accident reports. It highlighted the lack of consistent findings in studies exploring the role of vessel characteristics in maritime accidents, which often result from different methods, databases, techniques and motivations used by each respective study for gathering and analysing data. Furthermore, as human error continues to be highlighted as the top-cited cause of accidents, this study examined the qualitative content of IMO accident reports in-depth to broaden our understanding of maritime accident risk factors. Using a data-driven approach, statistical (ANOVA) and advanced text-mining techniques (using IRAMUTEQ software) were applied to extract meaning from the semi-structured and unstructured narrative descriptions that constitute most of the national administrations’ investigation reports to the IMO. Building on the text analysis of the IMO accident data, we proposed the Accident Maritime Ecosystem framework, which incorporates individuals, the ship organisation (on board), the internal ship ecosystem (on board and onshore), the external ship ecosystem (external factors) and the global maritime ecosystem (policies and regulations); moreover, it identifies these entities as risk factors in maritime accidents. The findings illustrate how accident reporting is largely human-centric and that as maritime transportation is becoming increasingly complex, there is a need for policy and organisational decision-makers to incorporate a broader scope of actors when considering maritime risk factors, which can be achieved by using the AME framework as a guideline.
Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients
Authors: Shahin Dina A. , Hegazy Khaled M. F. , Elsherif Mohammed , Sayed-Ahmed Nagy A. , Elwasify Mohamed , Helmy Eman , Abdel Razek Ahmed Abdel Khalek , Tharwat Samar
Published: April 2023

Background

Neuropsychiatric manifestations of lupus (NPSLE) are considered one of the major and most devastating lupus manifestations. The aim of this study was to assess the neuropsychiatric manifestations in systemic lupus erythematosus (SLE) patients and estimate the effectiveness of brain magnetic resonance spectroscopy (MRS) and anti-ribosomal P antibody test in early detection of NPSLE. This cross-sectional study was carried out on 50 SLE patients. Demographic, clinical, and therapeutic data were assessed. All patients were subjected to thorough rheumatological and neuropsychiatric evaluation. Serologic tests included antinuclear antibodies, anti-double-stranded DNA, and anti-ribosomal P protein antibodies. Radiologic evaluation included brain MRS.

Results

The mean age was 26.9 ± 98.9 years; the median disease duration was 18 (0–108) months. Headache was the most common neurological symptom (40%). Depression was not detected in 29 patients (58%), mild in 15 patients (30%), and moderate in 6 patients (12%). Anti-ribosomal P antibody titer was significantly elevated in patients with active in comparison with those with inactive lupus disease (p= 0.026). Brain MRS showed a statistically significant reduction in N-acetylaspartate creatine ratio (NAA/Cr) among patients with active lupus disease (p= 0.015) with a statistically significant increase in choline creatine ratio (Cho/Cr) among patients with inactive lupus disease (p= 0.049). There was a statistically significant negative correlation between the level of NAA/Cr and anti-ribosomal P antibody titer among patients with active lupus disease (p< 0.001).

Conclusions

Headache is the most common neurological manifestation among SLE patients. Anti-ribosomal P antibody titer is elevated in active SLE patients. The changes of NAA/Cr and Cho/Cr in brain MRS can be of help to differentiate between the active and inactive SLE.
Clinical profile of duplex kidneys in children and its association with vesicoureteric reflux
Authors: Perveen K Athiya , Mathews Shirbin Joe , Varghese Thomas P
Published: April 2023

Background

Duplex kidney is a relatively common renal anomaly with a wide array of associations. With routine antenatal screening it is increasingly diagnosed these days. With this study, we aim to assess the clinical profile, prevalence of vesicoureteric reflux and highlighting the need for aggressive workup and management in selected cases to prevent further renal damage.

Results

Fifty-three children with duplex kidneys who attended the department of pediatric surgery at our institution from December 2016 to December 2021 were included in the study. The most common mode of presentation was urinary tract infection (58%). Fifty-three percent had an antenatally detected renal anomaly (out of these 46% were asymptomatic, 33% had UTI and 11% had other symptoms like straining, incontinence and abdominal mass). Sixty-one percent of patients were conservatively managed and 19 patients needed surgical intervention. Ureterocele was the most common condition necessitating surgery. Prevalence of vesicoureteric reflux was 60% and was comparable with other studies. Thirty-six percent of patients had renal scarring. Among the patients with scarring, 84% had VUR and 63% had febrile UTI.

Conclusion

Duplex kidney though a common congenital anomaly, requires a systematic evaluation to detect its various associations and a structured management protocol according to the associations. It has a high incidence of VUR which is a potentially hazardous condition which can affect the renal function if not evaluated and managed appropriately. Duplex can also be associated with obstructive conditions like PUJO, ureterocele, and ectopic megaureter which can cause rapid deterioration of renal function if not managed early enough. Though majority of the patients need only follow-up and antibiotic prophylaxis, there may be a certain sub group of patients who develop early scarring and need aggressive management. Our study aims to highlight the need to detect such patients early enough to reduce the morbidity.