bluuebunny/crossref_metadata_2025 huggingface dataset:
The emergence of three-dimensional chiral domain walls in polar vortices
Authors: Susarla Sandhya , Hsu Shang-Lin , Gómez-Ortiz Fernando , Garcia-Fernandez Pablo , Savitzky Benjamin , DAS SUJIT , Behera Piush , Junquera Javier , Ercius Peter , Ramesh Ramamoorthy , Ophus Colin
Published: February 2023

Chirality or handedness of a material can be used as an order parameter to uncover emergent electronic properties for quantum information science. Conventionally, chirality is found in naturally occurring biomolecules and magnetic materials. Chirality can be engineered in a topological polar vortex ferroelectric/dielectric system via atomic-scale symmetry-breaking operations. We use four-dimensional scanning transmission electron microscopy (4D-STEM) to map out topology-driven three-dimensional domain walls, where the handedness of two neighbor topological domains change or remain the same. The nature of the domain walls is governed by the interplay of local perpendicular (lateral) and parallel (axial) polarization with respect to the tubular vortex structures. Unique symmetry-breaking operations and the finite nature of domain walls results in a triple point at the junction of chiral and achiral domain walls. The unconventional nature of the domain walls with triple point pairs may result in unique electrostatic and magnetic properties potentially useful for quantum sensing applications.
Prognostic Factors and Outcomes of Kasai Portoenterostomy (KPE): Nine Year Experience from a Lower Middle-Income Country
Authors: Wickramasekara Nipun , Ignatius Jenosha , Lamahewage Ananda
Published: February 2023

Purpose
Outcome data after Kasai Portoenterostomy (KPE) reported worldwide shows considerable regional and institutional variation. It is not known whether the same standards of outcomes reported in western world can be replicated in resource-poor countries.
Methods
We reviewed 79 patients of which 43 had completed a 2-year minimum follow-up. Two cohorts were based on age at KPE. Median age at surgery was 60 days.
Results
Clearance of jaundice (COJ) at 3 months was 20.93% and was not affected by age at surgery (p = 0.295). Four patients (9.3%) received liver transplant and 16 patients (37.21%) were recorded dead at a median age of 7 months. Native liver survival (NLS) was 53.49% and Overall survival (OS) was 62.79%. Kaplan-Meier estimated 4- and 6-year NLS were 55.8% and 49.6% respectively. There was a significant difference in the NLS between early and late surgery groups.
Conclusion
Whilst causes for low COJ need to be explored, this data reaffirm that early surgery has a significant favorable effect on survival. NLS was comparable with data from the developed world whereas low OS is explained by limited access to transplant. Thus, where the survival depends on native liver longevity, emphasis should be on as early KPE as possible.
The Effectiveness of Implementing Augmented Reality to Enhance Trainees’ Achievements
Authors: Alnajdi Sameer
Published: February 2023

The AR technology provides a view of the actual universe while coordinating with the simulated objects and the powerful tools, increasing trainees' performance and motivation. This paper examined trainees' performance after adopting AR in the e-training. These trainees enrolled in a First-Aid training course offered online by the Saudi Red Crescent Authority. Results have been analyzed and investigated to find the effectiveness of AR in a learning environment against a traditional learning environment. The finding showed that the trainees in the experimental group with the AR technology attained a more excellent score with a significantly higher mean (M = 87, SD = 1.87) than the trainees in the control group (M = 77, SD = 1.78). Moreover, trainees showed positive perceptions toward adopting AR in the e-training. Those who had AR in training for the first time were excited and wanted to have the same experiment again.
Aneuploid circulating endothelial cells with prognostic value in locally advanced breast cancer patients after neoadjuvant chemotherapy
Authors: Li Minghui , Liu Yuelin , Han Xu , Li Tao , Zhang Zhizheng , Xue Ningyi , Liang Mengdi , Ma Ge , Xia Tiansong
Published: February 2023

Background: Aneuploid circulating endothelial cells (CECs) are an indicator in breast cancer (BC). Significant changes of aneuploid CECs occurred during neoadjuvant chemotherapy (NCT). The aim of this study was to explore the predictive and prognostic value of aneuploid CECs in locally advanced breast cancer (LABC) patients with different NCT responses.
Methods: Breast cancer patients received an EC4-T4 NCT regimen. A novel subtraction enrichment and immunostaining fluorescence in situ hybridization (SE-iFISH) strategy was applied for detection of CECs (CD45–/CD31+/DAPI+). Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive value of aneuploid CEC counts in distinguishing NCT-resistant patients from sensitive ones. All patients were observed for progression-free survival (PFS) and overall survival (OS).
Results: The CEC counts at any time point did not show the ability to predict the efficacy of NCT. The difference of the CECs between post-chemotherapy level and baseline could be sufficient to distinguish chemotherapy-resistant cases from other cases in Hormone+Her-2-/+ (HR+) BC patients. Patients with reduction of CECs after all courses of NCT were associated with higher probability of PFS.
Conclusion: Variation of aneuploid CECs during NCT may have some ability to predict chemotherapy response in patients with HR+ breast cancer. The decrease of aneuploid CECs number after all courses of NCT indicate better treatment outcomes in LABC patients.
Optimal Control Strategy for PEM Electric Vehicle using Matlab Simulink
Authors: Ahuja Ajay , Waghole D R , Ramdasi Sushil S
Published: February 2023

The conventional fossil fuels are being replaced by alternate energy sources very fast. This is mainly due to the limited resources left in the Nature and the polluting characteristic of fossil fuel. Only thirty additional years are left for the supply of fossil fuels. The extreme climate change is largely attributed to automotive fossil fuel burning. The advent of pure Electric vehicles has resulted in reduction of harmful greenhouse gas emissions. It addresses the answer to the concerns of oil resource depletion, air pollution and climate changes. The benefit of using electric power in automotive sector is immense. However, the outcome of hybrid EVs can surpass pure EVs due to its capability of charging on the go, hence no extra charging time. In absence of any moving parts in a fuel cell, the maintenance and noise are also minimal. PEM fuel cell is a most eligible power source having reduced emissions and high efficiency characteristics. The efficiency of hybrid vehicle is a result of charging effectiveness. Control Strategy plays an important role in conservating and elevating energy whenever required. These are the energy power banks to optimize battery sizing and minimize losses. This paper explains a control strategy to enhance efficiency of FCHV system along with reduction of hydrogen consumption. This is achieved by maximising fuel cell efficiency by balancing the power split between battery and fuel cell. The rule based strategy results in maximising fuel cell system efficiency by sustaining the state of charge (SOC) of the battery. The SOC is aimed to be kept around a value which can address extremely low charge and high charge condition of the battery. At the same time, load on fuel cell is switched in a manner so as not to have a sudden ascent or descent of power, which helps in preventing the terminal deterioration in the fuel cell.
Predicting heart failure symptoms in breast cancer patients receiving Trastuzumab using cardiovascular magnetic resonance strain assessment
Authors: Yeo Jian L , Taha Ahmed H , Mahjob Mayada , Sosin Michael D
Published: February 2023

Purpose: To assess the ability of global longitudinal strain (GLS) with cardiovascular magnetic resonance imaging (CMR) to detect cancer therapy-related cardiac dysfunction (CTRCD) and predict heart failure symptoms.
Methods: Breast cancer patients who had undergone CMR for monitoring of left ventricular (LV) function while receiving Trastuzumab were retrospectively recruited. Baseline LV volumes and GLS before commencement of Trastuzumab were compared with follow-up scans at 3, 6, 9, and 12 months. CTRCD was determined using either the GLS criteria (defined as >5% absolute reduction or >12% relative reduction of GLS) or ejection fraction (EF) criteria (defined as >10% absolute reduction to <50% or >20% absolute reduction from baseline values). The primary outcome was patient reported heart failure symptoms within one year.
Results: Thirty female breast cancer patients with a mean age of 64±10 years were recruited. Both GLS (20.2±3.1% vs 23.0±3.0%, p<0.001) and EF (61.9±5.7% vs 66.0±6.0%, p<0.001) declined at 3 months compared to baseline and remained low until 12 months. Nine participants (30%) developed heart failure symptoms within one year. More CTRCD was diagnosed using GLS compared to EF criteria (67% vs 10%, p<0.001). The sensitivity and specificity to predict HF symptoms at 1-year were 78% and 35% for GLS, and 11% and 91% for EF, respectively.
Conclusion: Both GLS and EF declined as early as 3 months after receiving Trastuzumab. GLS has greater sensitivity than EF to predict heart failure symptoms at 1-year. GLS assessment in cardiac CMR surveillance during chemotherapy may provide earlier detection of subclinical heart failure than using EF alone.
Total Arch Replacement for Aortic Arch Aneurysm with Cold Agglutinin Disease after Rituximab and Plasmapheresis
Authors: Mitsuishi Atsuyuki , Miura Yujiro , Saeki Kyosuke , Nomura Yoshinori , Yoshifumi Katsumata , Yoshida Keisuke
Published: February 2023

Background:
Cold agglutinin disease can lead to significant complications, specifically for patients undergoing arch repair requiring hypothermic circulatory arrest. Rituximab and plasmapheresis are treatments for cold agglutinin disease; therefore, we used them under consultation of hematologists before mild hypothermic aortic arch surgery maintaining the body temperature above thermal altitude.
Case presentation:
We describe an 86-year-old male with acute Type A aortic dissection who had been treated for rheumatoid arthritis and a 55-mm thoracic aortic aneurysm as an outpatient. The patient was scheduled to undergo urgent surgery for a Type A intramural hematoma and progressive aortic aneurysm; however, blood clotting was observed on a laboratory test and cold agglutinin was detected. Consequently, we rescheduled the urgent surgery. Under consultation of hematologists, rituximab was initiated 3 months before surgery, and plasmapheresis was performed 2 days before surgery for cold agglutinin disease. Then, total arch replacement under mild hypothermia with the frozen elephant trunk technique was performed by maintaining cerebral and lower body perfusion. The postoperative course was uneventful. On the 42nd postoperative day, the patient was discharged without any neurological deficits.
Conclusions:
We report a case of total arch replacement with mild hypothermia for aortic arch aneurysm with cold agglutinin disease after rituximab treatment and plasmapheresis.
Comparison of the effect of the generative model on the performance of deep neural networks and transformer in contextual social bot detection
Authors: Sadeghi Niki , Riahi Noushin
Published: February 2023

considering the important role of social networks and the affectability of people on different issues by these networks, the presence of various types of bots in them is a security risk for the networks. There are many types of bot detection techniques, but the structure of social bots is constantly changing and updating, which makes them run away from bot detection techniques, and finding a sustainable approach to this problem has become a new issue. In addition, in the real world, social bots, despite the important role they have, are far fewer than real users, and the available data set reflects this. In certain social media, we can collect a million real profiles with an easy crawl, but finding a bot account is not that easy. Facing this problem, some bot detection methods, including supervised/unsupervised machine learning methods and neural networks, do not work accurately or are dysfunctional. The proposed method in this paper is to detect Twitter bots based on the content of tweets, which means the text of each tweet, and not using the highly updatable profile information. In this regard, recommended applying algorithms proper to analyze text data, one of which is based on a deep neural network, att_BiLSTM, which is a two-directional LSTM with an attention mechanism, and BERT, which is a transformer. It was also shown that by using the attention layer in BiLSTM, the model's accuracy would be near to the accuracy of BERT's transformer, which is an algorithm based on context. Also, with the presence of the attention layer in att_BiLSTM, the number of LSTM units in BILSTM can be less, and the same accuracy as BILSTM with a larger number of LSTM units is achieved. To reduce the imbalance of data and improve the accuracy of the bot detection, samples have been increased in a set of bots with a special type of Generative Adversarial Networks algorithm called Seq-GAN, which is suitable for discrete and sequential data. Then the difference performance in deep neural networks and transformer showed after using generative model.
Blood Cadmium and Lead Levels and Bone Mineral Density Are Negatively Correlated in Adult Women in U.S
Authors: Hu Chaotao , Li Chengyuan , Lv Jinchang , Hou Biao , Xie Songlin
Published: February 2023

The aim of this study was to investigate the association between blood cadmium levels (BCL) and blood lead levels (BLL) and bone mineral density (BMD) in people aged 20 to 59 years. Using data from the 2011–2018 National Health and Nutrition Examination Survey (NHANES), the researchers used multiple logistic regression models to examine the associations between BCL, BLL, and lumbar BMD. Fitting smooth curves and generalized summation models were also used. In subgroup analyses stratified by sex, the negative correlation between BCL, BLL, and lumbar BMD remained negative in women but not significant in men. In a subgroup analysis stratified by race, an inverse association between blood cadmium and lumbar BMD was observed only in whites. The negative association between BLL and lumbar BMD remained negative among whites, blacks, and Mexican Americans, and showed a U-shaped curve among other races.
Achieving energy transformation: Metal intensity for the development of China's photovoltaic roadmap towards 2060
Authors: Gómez Moisés , Xu Guochang , Li Yan , Liao Junlin , Lu Xi , Li Jinhui , He Kebin , Liu Lili , Zeng Xianlai
Published: February 2023

The target to achieve carbon neutrality is to enforce explosive growth of the global solar photovoltaic (PV) industry. This may involve severe resource constraints to meet their future metal demands. Herein, we consider different scenarios for the latest Chinese solar PV roadmaps and mature photovoltaic sub-technologies that may dominate. We estimate metal intensities, supply material risks, end-of-life photovoltaic modules, energy intensity, and costs associated with deploying PV panels and analyze dynamic processes from 2000 to 2060. Results show that the strength of metals varies widely between scenarios and dominant sub-technologies, ranging from 30% to 1300%. Annual supply pressures suggest metal demand will be challenging, peaking in 2040-2045. According to priorities, domestic production of gallium, tellurium, indium, selenium, and silver is likely in short supply in 2020, while production of aluminum, copper, tin, and silicon is under moderate supply pressure, suggesting that China could be at risk of missing out on its future PV roadmaps. To mitigate future demand for metals and assess future energy security, efforts should be made to implement regulations, policies, and investments in circular economy strategies.
The Usage of Arbuscular Mycorrhizal Fungi (Amf) as a Biofertilizer
Authors: jha Subhesh saurabh , Songachan L. S.
Published: February 2023

Arbuscular Mycorrhizal Fungi (AMF) are a group of soil-borne fungi that form symbiotic relationships with the roots of most plants, including crops. In this relationship, the fungus provides the plant with nutrients, such as phosphorous, in exchange for carbohydrates produced by the plant through photosynthesis. The use of AMF as a biofertilizer involves the application of these fungi to soil to enhance plant growth and improve nutrient uptake. Studies have shown that AMF can increase plant growth, drought tolerance, and nutrient uptake, leading to improved crop yields. The fungi form a network of hyphae in the soil, which helps to increase the soil's water-holding capacity, as well as its ability to retain nutrients. This can lead to improved plant growth and health, even in nutrient-poor soils. In addition, the use of AMF as a biofertilizer can help to reduce the dependence on synthetic fertilizers, which can have negative environmental impacts. AMF can help to improve soil fertility, increase plant nutrient uptake, and reduce soil erosion, leading to more sustainable agriculture practices. However, it is important to note that the effectiveness of AMF as a biofertilizer can vary depending on several factors, including the species of AMF used, the type of crop being grown, and the conditions of the soil. Additionally, the proper application and management of AMF is important to ensure its effectiveness. In conclusion, the use of AMF as a biofertilizer has the potential to enhance plant growth, improve nutrient uptake, and promote sustainable agriculture practices.
How Significant is Trade, Macroeconomic Management, and Economic Integration for Foreign Indebtedness in West African Countries?
Authors: Aladejare Samson Adeniyi
Published: February 2023

The implications of trade, macroeconomic management, and economic integration for external debt have rarely been researched in public debt studies. Hence, the novelty of this study’s contribution to the literature hinges on identifying the significance of these factors in external debt accumulation for West African countries from 1981 to 2020. Methodologically, the study applied pooled mean group analytical approach due to its significance in identifying short-term heterogeneous effects. Empirical deductions from the study indicated that trade and economic integration would trigger external debt accumulations in the short term, while the implication of macroeconomic management is neutral. However, the long-term impacts of trade and economic integration demonstrate a diminishing effect on external debt, while macroeconomic management has weak significance. The individual country short-term results indicated that trade enhanced the volume of external debt in almost all countries examined. Also, macroeconomic management and economic integration were revealed to have moderate and insignificant effects on external debt accumulation. Furthermore, the role of financial sector uncertainty, political imbalance, insurgency, and disease outbreaks was affirmed as accompanying exacerbating factors for foreign indebtedness in West African countries.JEL Classification:E6, F34, H63.
A standard convention for particle-level Monte Carlo event-variation weights
Authors: Bothmann Enrico , Buckley Andy , Gütschow Christian , Prestel Stefan , Schönherr Marek , Skands Peter , Andersen Jeppe R. , Bhattacharya Saptaparna , Butterworth Jonathan , Singh Chahal Gurpreet , Corpe Louie , Gellersen Leif , Gignac Matthew , Höche Stefan , Kar Deepak , Krauss Frank , Kretzschmar Jan , Lönnblad Leif , McFayden Josh , Papaefstathiou Andreas , Plätzer Simon , Schumann Steffen , Seymour Michael H. , Siegert Frank , Siódmok Andrzej
Published: February 2023

Streams of event weights in particle-level Monte Carlo event
generators are a convenient and immensely CPU-efficient approach to
express systematic uncertainties in phenomenology calculations,
providing systematic variations on the nominal prediction within a
single event sample. But the lack of a common standard for labelling
these variation streams across different tools has proven to be a major
limitation for event-processing tools and analysers alike. Here we
propose a well-defined, extensible community standard for the naming,
ordering, and interpretation of weight streams that will serve as the
basis for semantically correct parsing and combination of such
variations in both theoretical and experimental studies.
Impact of personnel policy on human resources management: Empirical evidence from Vietnamese enterprises
Authors: Quoc Thinh Tran , Tran Mai Uoc , Anh Tuan Dang , Chi Danh Luu
Published: February 2023

Human resources have an essential meaning in stability and sustainability of business activities. The quality of human resources contributes to increasing intelligence and thinking, as well as productivity and efficiency in all activities of an enterprise. The study aims to determine the influence of different factors on Vietnamese enterprises’ human resources management, including staffing plans, personnel selection, employee use, resource training, employee rating, and bonus policies. Exploratory factor analysis is employed to test the factors related to the research model. The sample comprises 417 leaders working at Vietnamese enterprises surveyed in 2021. The paper uses panel data to test the regression using OLS method. The selected enterprises are diverse in industry and size to ensure representativeness and are based in Ho Chi Minh City. The results elicit that staffing plans and bonus policies are two of the six factors that positively affect the human resources management of Vietnamese enterprises. The findings also show that staffing plans are the factor that has the most substantial impact on human resources management. Finally, the paper has proposed some policy suggestions to stabilize human resources management at Vietnamese enterprises to attract quality talent.
Skrajny indywidualizm jako źródło dysfunkcji wspólnotowych w nauczaniu papieża Franciszka
Authors: Szulist Janusz
Published: February 2023

Papież Franciszek odnosi się w swoim nauczaniu do sytuacji współczesnego człowieka, który jest przedmiotem oddziaływania przeróżnych trendów kulturowych, ekonomicznych czy spo-łecznych. Sytuacja jednostki jest współcześnie determinowana przez skrajny indywidualizm, będący przedmiotem analiz niniejszego artykułu. Koncentrowanie się tylko i wyłącznie na so-bie podważa istnienie więzi wspólnotowej, sprzyja również narzędziowemu interpretowaniu sytuacji drugiego człowieka. Skrajny indywidualizm stwarza także korzystne uwarunkowania dla utopii odrealniających rzeczywistość. Skutkami ulegania skrajnemu indywidualizmowi są acedia i pesymizm w działalności duszpasterskiej Kościoła oraz konsumpcjonizm w aspekcie stosunków społecznych. Skrajny indywidualizm skłania do materializmu, a także przyczynia się do pogarszania kwestii ekologicznej. Bazę źródłową tekstu stanowi nauczanie papieża Fran-ciszka. W artykule wykorzystano metodę analityczno-syntetyczną.
John Ray: “Divinity is my Profession”
Authors: Drozdek Adam
Published: February 2023

Summary. John Ray was primarily interested in his work as a naturalist. However, prompted by his conscience and the sense of his priestly obligation, he authored three books of religious character: one on physico-theology, one on sacred physics, and one on practical theology. The article presents some of his views expressed in these books.
Polysaccharide and Cyclodextrin-Based Monolithic Chiral Stationary
Phases and its Application to Chiral Separation
Authors: Aboul-Enein Hassan Y. , Kannappan Valliappan , Kanthiah Selvakumar
Published: February 2023

The recent development of monolithic chiral stationary phases (CSPs) for liquid chromatography
(LC) is mainly focused on reducing backpressure, maximizing flow rates, faster run
time, column efficiency, and stability. This review paper emphasizes recent progress in the development
of polysaccharide and cyclodextrin-based monolithic CSPs. Further the paper draws attention
to competing techniques, like non-porous particle-packed columns, core-shell and monoliths
as chromatographic support matrix, available for achieving fast and efficient chromatographic separation.
A brief discussion on the three main classes of chiral monolithic stationary phase viz. silica,
organic polymer and hybrid-based monolithic stationary phases is also presented. In addition,
the paper highlights various studies on the application of monolith chiral CSPs in LC and capillary
electrochromrography separation and analysis of chiral compounds.
Revealing the Role of the Arg and Lys in Shifting Paradigm from BTK Selective Inhibition to the BTK/HCK Dual Inhibition - Delving into the Inhibitory Activity of KIN-8194 against BTK, and HCK in the Treatment of Mutated BTKCys481 Waldenström Macroglobulinemia: A Computational Approach
Authors: Elamin Ghazi , Aljoundi Aimen , Alahmdi Mohamed I. , Abo-Dya Nader E. , Soliman Mahmoud E.S.
Published: February 2023

Background:

Despite the early success of Bruton's tyrosine kinase (BTK) inhibitors in the treatment of
Waldenström macroglobulinemia (WM), these single-target drug therapies have limitations in their clinical applications,
such as drug resistance. Several alternative strategies have been developed, including the use of dual inhibitors,
to maximize the therapeutic potential of these drugs.

Objective:

Recently, the pharmacological activity of KIN-8194 was repurposed to serve as a ‘dual-target’ inhibitor of
BTK and Hematopoietic Cell Kinase (HCK). However, the structural dual inhibitory mechanism remains unexplored,
hence the aim of this study.

Methods:

Conducting predictive pharmacokinetic profiling of KIN-8194, as well as demonstrating a comparative
structural mechanism of inhibition against the above-mentioned enzymes.

Results:

Our results revealed favourable binding affinities of -20.17 kcal/mol, and -35.82 kcal/mol for KIN-8194 towards
HCK and BTK, respectively. Catalytic residues Arg137/174 and Lys42/170 in BTK and Arg303 and
Lys75/173/244/247 in HCK were identified as crucial mediators of the dual binding mechanism of KIN-8194, corroborated
by high per-residue energy contributions and consistent high-affinity interactions of these residues. Prediction of
the pharmacokinetics and physicochemical properties of KIN-8194 further established its inhibitory potential, evidenced
by the favourable absorption, metabolism, excretion, and minimal toxicity properties. Structurally, KIN-8194
impacted the stability, flexibility, solvent-accessible surface area, and rigidity of BTK and HCK, characterized by
various alterations observed in the bound and unbound structures, which proved enough to disrupt their biological
function.

Conclusion:

These structural insights provided a baseline for the understanding of the dual inhibitory activity of KIN-
8194. Establishing the cruciality of the interactions between the KIN-8194 and Arg and Lys residues could guide the
structure-based design of novel dual BTK/HCK inhibitors with improved therapeutic activities.
A DMA-WSN Based Routing Strategy to Maximize Efficiency and Reliability
in a Ship to Communicate Data on Coronavirus
Authors: Sethi Deepak , Anand Jyoti , Shukla Meenu , Tripathi Ankita
Published: February 2023

Background:

The Sensor Nodes (SNs) are deployed in an environment where human
beings are not able to perform the tasks. Wireless Sensor Network (WSN) is used for applications in
security, military surveillance, habitat monitoring, agriculture, etc. All these applications require
SNs to have good battery backup so that they can perform for a long duration. Recent research
shows that agent-based strategies increase the efficiency of WSN in comparison to conventional
WSN in which every SN is static. During the current pandemic of Covid-19, various public resources,
such as train, bus, hotels, etc., were used for isolating the Covid-19 patients. In a similar
way, the ship helps to keep humans away from each other.

Methods:

In the current work, WSN has been deployed on a ship to monitor the health of Covid-19
patients. A 109 m long ship with 12.8 m altitude and 23 m width along with 6 decks has been considered.
The SNs have been deployed on different floors of the modern ship. Six decks have been
considered, and on each deck, 50 SNs have been deployed. A Drone-driven Mobile Agent (DMA)
routing strategy has been proposed. DMA is a software program that moves across the network
around the SNs and collects information from wearable sensors, such as body temperature, SpO2,
etc. DMA is capable of aggregating and delivering the data packets to the base station for further
processing. DMA performs information processing, local processing, and collaborative signaling.
DMA can move randomly or in fixed locations.

Results:

Results have been compared with multi-sink and mobile sink strategies, which reveal that
the proposed and simulated technique enhances the life span and throughput of the network to monitor
Covid-19 patients effectively.

Conclusion:

Results revealed the proposed technique to enhance the lifetime (DMA-fixed: 11633
rounds and DMA-random: 11740 rounds) and throughput (DMA-fixed: 148788 packets sent and
DMA-random: 150008 packets sent) of the network.
Global Value Chains and the Slowing Down of Globalisation
Authors: Della Posta Pompeo
Published: February 2023

Global value chains (GVCs) have been a major feature of the phase of economic globalisation that began after the 1980s. After the global financial crisis of 2007-08, however, this phase has come to an end, being replaced by one characterized by a significant slowdown in the degree of international economic openness, due to not only economic but also geopolitical reasons.. GVCs have also shown a slowing growth trend after then.

The future scenarios for GVCs, however, suggest the possibility that they may be more resilient than expected.

A first theoretical explanation provided in the literature argues that the reshoring of foreign intermediate production would be prevented by the high sunk costs that would have to be incurred.

However, an additional possible reason for GVCs resilience - this is the main theoretical contribution of this article - is due to the option of friendshoring or nearshoring, rather than reshoring. Moving the production to more suitable foreign destinations, characterized by a political or geographical proximity with the domestic one, would avoid the newly perceived strategic and geopolitical costs, while retaining the economic benefits of offshoring, thereby making GVCs resilient.
The Legal Nature of New Generation Free Trade Agreements: Lessons from the CETA Saga
Authors: Pereira Coutinho Francisco
Published: February 2023

The Comprehensive Economic and Trade Agreement (CETA) is a “new generation” bilateral “mixed” free trade agreement signed on 30 October 2016 between Canada and the European Union alongside its Member States. In the European Union, “mixed” trade agreements follow an adoption procedure that determines, in the best-case scenario, a substantial delay to their entry into force, and, in the worst, a veto by Member States that damages the international standing of the European Union. The European Com­mission bowed to Member States’ pressure and decided to qualify CETA as a “mixed agreement” instead of an “EU-only agreement”. That the “guardian of the Treaties” had no constitutional leeway on the choice of CETA’s approval form became clear after the decision of the Court of Justice on the free trade agreement nego­tiated between the European Union and Singapore (Opinion 2/15). CETA’s “mixed” nature determines that its application is limited and provisional, and under a permanent Damocles sword existential threat.
Green horizons – Towards more sustainable trade after the TSD Review
Authors: Blot Eline
Published: February 2023

All eyes are on the European Commission following the communication on a new approach to Trade and Sustainable Development (TSD) Chapters in EU Free Trade Agreements (FTAs). The focal point of EU trade policy recently shifted back towards bilateral trade agreements with a greater scrutiny on the sustainability objectives embedded in the TSD Chapters such as tackling global emergencies including the climate crisis, deforestation, and biodiversity loss. But what does this new approach entail, and how effective will it be at improving the monitoring and enforceability of the TSD Chapters? This article reviews the new TSD Chapter approach and assesses its overall objective to address sustainability concerns linked to international trade. The article discusses missed opportunities for enhancing sustainability in EU trade agreements and reflects what the new TSD approach could mean for newly concluded and ongoing trade agreements.
Perkembangan Kognitif Peserta Didik Dalam Proses Pembelajaran Tematik Di Madrasah Ibtidaiyah (Studi Kasus di MIN 1 Bantul)
Authors: Badriah Laelatul , Andi Khamdan Nur
Published: February 2023

The development of a student's ability to understand the material taught in the learning process is greatly influenced by the cognitive abilities of students. The ability of students in the thematic learning process really needs to pay attention to cognitive development which is closely related to the development and growth of students. MIN 1 Bantul strives to implement the learning process by paying attention to the development of students. MIN 1 Bantul strives to implement the learning process by paying attention to the development of students. In addition, one of the efforts made is the preparation of thematic learning in MIN 1 Bantul paying attention to the standards of the educational process, the learning process that adheres to Piaget's theory of cognitive development, and the thematic learning process using and holding cognitive theory. According to Piaget the learning process at the age of 7-12 is called the concrete operational stage. This research to determine whether cognitive development can have an impact on the progress of student learning outcomes. This type of research is qualitative research. The population of this study was MIN 1 Bantul teachers, the data collection method in this study used observation, interviews and documentation. The population of this study was MIN 1 Bantul teachers, the data collection method in this study used observation, interviews and documentation. The technical data analysis used in this study is qualitative descriptive analysis. The results showed that the cognitive development of students will have a good effect on the progress of student learning outcomes, both the learning process and the final results of student learning outcomes. In this case, the minimum age that is standardized to be able to start basic education is 7 years old, citing the child's mature and cognitive readiness to receive teaching materials has matured
Keyword: Cognitive Development, Thematic Learning, Student
The relationship between breastfeeding contact with breastfeeding self-efficacy in Wangaya Hospital Denpasar City
Authors: Suartiningsih Sang Ayu Kompiang , Astiti Ni Komang Erny , Ningtyas Listina Ade Widya , Sriasih Ni Gusti Kompiang , Wirata I Nyoman
Published: February 2023

Background :Breastfeeding is the best care for babies in early life. Lack of self- confidence of mothers is one of the causes of breastfeeding failure. Breastfeeding self-efficacy can be used to see or identify mothers who are at hight risk for stopping the breastfeeding process prematurely. Interventions that can improve breastfeeding self-efficacy care providing support and counseling during antenatal, perinatal and postnatal management. To achieve successful breastfeeding, WHO has set a special time for contact with lactation counselor orlactation clinic known as Breastfeeding contact.

Objectives :This study aims to analyze the relationship between breastfeeding contact and breastfeeding self- efficacy in Wangaya Hospital, Denpasar City.

Methods :The study was designed with an observational analytic approach with a crosssectional approach, in Februari-April 2022. The data were collected from breastfeeding mothers who bring their babies control for the first time and or 7 days old. The sampel was obtained by total sampling method, data analysis using bivariate and statistical testing using Chi-square test.

Results :The results showed that of 38 respondents, were 73.68% had good breastfeeding contact and 57.89% had a good of breastfeesing self-efficacy.The results of cross tabulation, respondents who had good breastfeeding contacts and had a good breastfeesing self-efficacy were 55.26%. The results of this study indicate that there is a significant relationship between breastfeeding contact and breastfeeding self- efficacy in Wangaya Hospital Denpasar City with ρ-value is 0.001.

Conclusions : Having regular breastfeeding contact can increase the breastfeeding self-efficacy.
Effectiveness of pelvic rocking exercise on length and pain in delivery women: A Meta-Analysis
Authors: Navelia Zesika Intan , Kasjono Heru Subaris , Virahaju Mahindria Vici
Published: February 2023

Background: Anxiety about prolonged and painful labor processes encourages the mother to do a section cesarean ( SC ), which is becoming one of the indications SC incidents increase globally. Pelvic rocking exercise using a birth ball has several benefits in helping mothers give birth, especially in the first stage. The movement by sitting on the ball and rocking using gravity can increase the release of endorphins that provide comfort and enhance duration in labor.

Objectives: To analyze the effectiveness of the pelvic rocking exercise using a birth ball on the duration of labor and reducing pain in the first stage of labor.

Methods: A systematic review and meta-analysis by conducting an article search strategy using an electronic database according to the PICO method by eliminating articles according to the inclusion criteria includes articles with a period of 2011 – 2021, in Indonesian or English, using the RCT or Quasy experimental method, and the respondents used are pregnant women with gestational age of 30 weeks and above..

Results: PRE using birth ball obtained statistically proven results to shorten the length and reduce labor pain than the control group. The experimental group had a significant effect in reducing labor duration and pain after intervention -1.13 [95% CI: -1.57, -0.09] p<0.00001 and -1.19 [95% CI: -1.48, -0.90] p <0.00001.
Conclusions: There is an effect of pelvic rocking exercise using a birth ball on decreasing length of labor and pain in the first stage phase. It is expected that this research can be a complementary therapy option with good benefits and easy procedures for independent and collaborative midwifery practice in providing comprehensive midwifery care
Effect of banana blossom vegetables for speed up recovery of perineal wounds
Authors: Zulaikha Layla Imroatu , Yunita Emi , A'yun Qurratul
Published: February 2023

Background: The process of delivery through the birth canal has a risk of experiencing perineal tears, perineal tears can occur spontaneously or tear through episiotomy. The presence of perineal wounds can be one of the predisposing factors for infection during the puerperium. Based on the Indonesian Health Profile in 2018, post-partum wounds are still a common cause of infection, reaching 80-90%. Complementary therapy is the right solution to overcome health problems. One type of biodiversity that can be used as herbal therapy to speed up recovery process of perineal wounds is banana blossom which contains iron which is needed for hydroxylation of proline, lysine, vitamins, flavonoids, and proteins. antioxidant effect which is indispensable in the wound healing process

Objectives: This study aims to determine the effectiveness of consuming banana flower vegetables to accelerate perineal wound healing.

Methods: This research is a quasi-experimental study with a Posttest Only Control Group design and then analyzed using a non-parametric test, namely the Mann Whitney test and a significance level of 0.05, to see the difference in perineal wound healing time between the control group and the experimental group

Results: Based on the results of statistical tests using the Mann Whitney U-Test, a p value of 0.000 <0.05 (α) was obtained which indicated that H1 was accepted and H0 was rejected, meaning that there was a difference in the duration of perineal wound healing between respondents who consumed banana flower vegetables and respondents who did not consume banana heart

Conclusions: Banana flower has a high antioxidant content which makes the process of joining the tissues on both sides of the wound due to tearing to take place more quickly. With the results of this study, it is hoped that all postpartum women who experience perineal tears can continue to consume banana flower vegetables until the perineal wound heals.
A STUDY ON AWARENESS OF ROLE PHYSIOTHERAPY IN LIFESTYLE MODIFICATION OF DIABETIS MELLITUS IN RURAL AREA (Preprint)
Authors: Pawar 4th Rutuja
Published: February 2023

BACKGROUND

There is a rise in diabetes prevalence in India due to a combination of factors such as poor diet, lack of exercise, and a disturbed sleep cycle and genetics. It is very important to be aware and educated about the diabetic diet and the importance of physical exercise in order to reduce the complications caused by diabetes, which reduces mortality and morbidity.

OBJECTIVE

To evaluate awareness of role of Physiotherapy in lifestyle modification in Diabetes mellitus in rural area.

METHODS

The study was conducted in subjects with type 2 diabetes mellitus who were clinically diagnosed with type 2 Diabetes mellitus. The study population was composed of 163 individuals which were above the age group of 30 years, further subdivided into 2 groups: 31 – 50 and 51 – 70 years. The validated questionnaire provided through which the level of awareness about role physiotherapy in lifestyle modification of diabetes mellitus were determined.

RESULTS

A total of 163 participants participated in this study. In the male and female participants included 67.4% of male and 32.5% of female Diabetic subjects respectively. Age group between 31 to 70 years is included in this study. The result revealed that 65% of people with poor knowledge about the role of physiotherapy in lifestyle modification of Diabetes mellitus, while 32% people had fair knowledge. The result also showed that, only a 3% people with good knowledge about the roles of physiotherapy in lifestyle modification of Diabetes mellitus.

CONCLUSIONS

The study revealed that, there is superficial knowledge about the roles of physiotherapy in lifestyle modification of diabetes mellitus in rural area. A very small amount of people was however found to be more knowledgeable about the roles of physiotherapy in lifestyle modification of diabetes mellitus when compared to other people from rural area.

CLINICALTRIAL

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Sacroiliac Joint Dysfunction in Endurance Runners Using Wearable Technology as a Clinical Monitoring Tool: Systematic Review (Preprint)
Authors: Evans Stuart
Published: February 2023

BACKGROUND

In recent years, researchers have delved into the relationship between the anatomy and biomechanics of sacroiliac joint (SIJ) pain and dysfunction in endurance runners to elucidate the connection between lower back pain and the SIJ. However, the majority of SIJ pain and dysfunction cases are diagnosed and managed through a traditional athlete-clinician arrangement, where the athlete must attend regular in-person clinical appointments with various allied health professionals. Wearable sensors (wearables) are increasingly serving as a clinical diagnostic tool to monitor an athlete’s day-to-day activities remotely, thus eliminating the necessity for in-person appointments. Nevertheless, the extent to which wearables are used in a remote setting to manage SIJ dysfunction in endurance runners remains uncertain.

OBJECTIVE

This study aims to conduct a systematic review of the literature to enhance our understanding regarding the use of wearables in both in-person and remote settings for biomechanical-based rehabilitation in SIJ dysfunction among endurance runners. In addressing this issue, the overarching goal was to explore how wearables can contribute to the clinical diagnosis (before, during, and after) of SIJ dysfunction.

METHODS

Three online databases, including PubMed, Scopus, and Google Scholar, were searched using various combinations of keywords. Initially, a total of 4097 articles were identified. After removing duplicates and screening articles based on inclusion and exclusion criteria, 45 articles were analyzed. Subsequently, 21 articles were included in this study. The quality of the investigation was assessed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) evidence-based minimum set of items for reporting in systematic reviews.

RESULTS

Among the 21 studies included in this review, more than half of the investigations were literature reviews focusing on wearable sensors in the diagnosis and treatment of SIJ pain, wearable movement sensors for rehabilitation, or a combination of both for SIJ gait analysis in an intelligent health care setting. As many as 4 (19%) studies were case reports, and only 1 study could be classified as fully experimental. One paper was classified as being at the “pre” stage of SIJ dysfunction, while 6 (29%) were identified as being at the “at” stage of classification. Significantly fewer studies attempted to capture or classify actual SIJ injuries, and no study directly addressed the injury recovery stage.

CONCLUSIONS

SIJ dysfunction remains underdiagnosed and undertreated in endurance runners. Moreover, there is a lack of clear diagnostic or treatment pathways using wearables remotely, despite the availability of validated technology. Further research of higher quality is recommended to investigate SIJ dysfunction in endurance runners and explore the use of wearables for rehabilitation in remote settings.