bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of the Target Criterion and Leading Indicators of Regulatory Influence in the Banking Sector
Authors: Osadcha N.V. , Artemenko D.M.
Published: March 2022

The article defines the essence and methods of measuring the target criterion and leading indicators of regulatory influence in the banking sector. It is proposed to supplement prudential banking supervision, based on tracking the economic standards of individual banks, with models of discriminant analysis for a comprehensive assessment of the financial condition and risk of bankruptcy of banks.
The use of the built-in reference matrix of discriminant analysis of the level of financial condition and the degree of risk of bankruptcy of the bank, as leading indicators of regulatory impact, will improve the quality of financial determination of its market value as a target criterion of regulatory impact on banking.
The reference matrix serves as a reliable indicator for informed decisions by owners, managers, customers and national regulators to maintain its effective functioning and further stable development.
The use of a range of values of the level of probability of bankruptcy, which is the inverse of the integral indicator of the financial condition of the bank, allows more differentiated determination of classes of banks by level of financial condition and group of banks at risk of bankruptcy.
The developed reference matrix as a starting point of methodological support of comprehensive assessment of market value of banks avoids mistakes in choosing the methodological approach and methods of calculating the market value of a particular bank and identify potential bankrupt banks for detailed revaluation of their loan portfolios and securities portfolios.
Evaluation of the possibility of detecting microbial contamination of microbial drugs via filtration
Authors: Kuleshova S. I. , Protsak S. A. , Romanyuk G. Yu. , Lisunova S. A. , Semenova E. N.
Published: March 2022

The study considered the possibility of using the membrane filtration method as a way of eliminating the antimicrobial effect upon determination of the microbial quality of antimicrobial medicines for oral administration. Azithromycin and amoxicillin powders for suspension, as well as levomycetin (chloramphenicol) and ciprofloxacin tablets were used as examples. The study demonstrated that in some cases the membrane filtration method precluded reliable results. In case of possible contamination of a medicinal product, suspended particles of the active ingredient deposited on a membrane filter may have an inhibitory effect on certain microorganisms due to the spectrum of action of the antimicrobial medicine. A supernatant facilitates filtration upon determination of the microbial quality; however, microorganisms may sediment on suspended particles of the test medicine in the process of suspension separation. The use of the membrane filtration method for the evaluation of the contamination of oral antimicrobial medicinal products should be based on the method validation, taking into account the solubility of the medicine, the composition of excipients, and experimental data on the absence of adhesion of microorganisms on the particles of excipients.
Understanding Mood of the Crowd with Facial Expressions: Majority Judgment for Evaluation of Statistical Summary Perception
Authors: Ueda Yoshiyuki
Published: March 2022

We intuitively perceive mood or collective information of facial expressions without much effort. Although it is known that statistical summarization occurs even for faces instantaneously, it might be hard to perceive precise summary statistics of facial expressions (i.e., using all of them equally) since recognition of them requires the binding of multiple features of a face. This study assessed which information is extracted from the crowd to understand mood. In a series of experiments, twelve individual faces with happy and neutral expressions (or angry and neutral expressions) were presented simultaneously, and participants reported which expression appeared more frequently. To perform this task correctly, participants must perceive precise distribution of facial expressions in the crowd. If participants could perceive ensembles based on every face instantaneously, expressions presented on more than half of the faces (in a single ensemble/trial) would have been identified as more frequently presented and the just noticeable difference would be small. The results showed that participants did not always report seeing emotional faces more frequently until much more emotional than neutral faces appeared, suggesting that facial expression ensembles were not perceived from all faces. Manipulating the presentation layout revealed that participants’ judgments highly weight only a part of the faces in the center of the crowd regardless of their visual size. Moreover, individual differences in the precision of summary statistical perception were related to visual working memory. Based on these results, this study provides a speculative explanation of summary perception of real distinctive faces. (247 words)
A TERM «METHODS» IN THE CONTEXT OF MODERN LINGUODIDACTICS
Authors: Щукин А.Н.
Published: March 2022

Статья посвящена содержанию термина «методика» и его использованию в преподавании РКИ в контексте современного развития лингводидактики.

The article focuses on the content of the term methodology of foreign language teaching and its use in the field of teaching Russian as a foreign language in the context of modern linguodidactics.
The XXIst century skills in teaching Russian as a foreign language
Authors: Шамонина Г.Н.
Published: March 2022

В статье рассматривается процесс формирования и развития гибких навыков студентов международного профиля в процессе обучения РКИ по проектной технологии. Автор показывает, что для их развития необходимо создание психолого-педагогических условий успеха, применение инновационных технологий и целенаправленная работа в процессе коллективной подготовки различных проектов. Даются практические рекомендации по организации самостоятельной проектной деятельности, предусматривающие коллективную форму работы с целью развития таких гибких навыков, как креативность, сотрудничество, лидерство, коммуникабельность, умение работать с информацией, решение задач межличностного взаимодействия и толерантность.

The article is focused on the process of soft skills formation and development in the students of international relationships majors in the process of teaching Russian as a foreign language (RFL) using project work. The author highlights that their development is closely related to the creation of psychological and pedagogical conditions for success, the use of innovative technologies and purposeful work in the process of collective preparation of various projects. Practical recommendations on the organization of independent project activities are given, providing a collective form of work in order to develop such soft skills as creativity, cooperation, leadership, sociability, the ability to work with information, solving problems of interpersonal interaction and tolerance.
SUBJECT AND NON-SUBJECT CONSTRUCTIONS IN NON-FUNCTIONAL DESCRIPTIVE TEXTS
Authors: Роговнева Ю.В.
Published: March 2022

В статье анализируются предикативные единицы, входящие в нефикциональные тексты – рекламные описания товаров в интернет-каталогах. Типовое значение качества, регулярное для описательных текстов, представляется в моделях как с выраженным, так и с невыраженным субъектом. Говорящий не эксплицирует субъект в тех случаях, когда характеризует описываемый товар в целом, экспликация субъекта представлена в моделях, где описывается часть целого предмета. Востребованность таких моделей в указанных текстах позволяет по-новому взглянуть на закрепившуюся в русистике теорию односоставных и неполных предложений.

The article analyzes predicative units included in non-functional texts – advertising descriptions of goods in online catalogs. A typical quality value, regular for descriptive texts, is represented in models with both a pronounced and an unexpressed subject. The speaker does not explicate the subject in those cases when he characterizes the described product as a whole, the explication of the subject is presented in models where a part of the whole object is described. The relevance of such models in these texts allows us to take a fresh look at the theory of one-part and incomplete sentences that has become entrenched in Russian studies.
RUSSIAN LANGUAGE AS A FACTOR OF PROFESSIONAL EDUCATION OF FOREIGN CITIZENS IN BELARUS
Authors: Короткевич И.И.
Published: March 2022

В учреждениях высшего образования Республики Беларусь в настоящее время для иностранных студентов разработано значительное количество образовательных программ на русском языке. Обучение на русском языке позволяет иностранным выпускникам, получившим дипломы учреждений высшего образования Республики Беларусь, развиваться в профессиональном плане. Русский язык для иностранных студентов в Беларуси становится средством их будущего профессионального развития.

At present, higher education institutions of the Republic of Belarus have developed a significant number of educational programs in Russian for foreign students. Education in Russian allows foreign graduates who have received diplomas from higher education institutions of the Republic of Belarus to develop professionally. The Russian language for foreign students in Belarus is becoming a means of their future professional development.
STRUCTURE AND CONTENT OF MAJORING LANGUAGE TRAINING COMPLEX FOR FOREIGN TECHNICAL PRE-MASTERS
Authors: Горбенко В.Д.
Published: March 2022

Статья посвящена вопросу обучения языку специальности на этапе предвузовской подготовки иностранных слушателей, планирующих учиться в магистратуре. Описываются особенности данного контингента обучающихся, предпосылки разработки специальных предмагистерских программ и основные проблемы их реализации. Отмечается необходимость повышения степени корреляции изучае-мых на занятиях по русскому языку материалов с выбранными магистерскими программами. В качестве возможного способа повышения эффективности учебного процесса предлагается использование учебного комплекса по языку специальности для работы в условиях автономного режима. Описывается структура и содержание данного учебного комплекса, определяются критерии составления текстотеки. Описывается система заданий, представленная в рабочей тетради и направленная на формирование и совершенствование навыков восприятия текстов по специальности (зрительно и на слух), вычленения в них основной информации, ее письменной фиксации и устной передачи основного содержания. Особое внимание уделяется описанию алгоритма самостоятельной работы иностранного слушателя, позволяющего ему построить индивидуальную образовательную траекторию. Предлагается алгоритм действий преподавателя, направленных на контроль полученных учащимся результатов.

The article covers matters of majoring language study at the stage of pre-university training of foreign trainees planning to do the masters. It describes the features of this trainee body, prerequisite for development of special pre-masters programs and main problems of their implementation. The need to increase the degree of correlation of materials studied at Russian language classes with selected master's programs is noted. As a practicable method to improve the effectiveness of educational process, it is proposed to use majoring language training complex to work in standalone mode. The article describes the structure and content of this training complex. Criteria for compiling text library are defined. It describes the system of tasks presented in workbook and aimed at forming and improving skills of (visual and aural) perception of majoring texts, extraction of basic information from them, its written recording and oral communication of main content. Particular attention is paid to description of algorithm of independent work for a foreign trainee, which allows a trainee to build an individual educational path. An algorithm of teacher's actions aimed at monitoring results of the trainees is proposed.
MEMORIAL COLLECTION OF THE OUTSTANDING ACADEMICIAN AND SCIENTIST IN THE FIELD OF LINGUISTICS V.G. KOSTOMAROV: CURRENT STATE, PERSPECTIVES OF STUDY AND PRESENTATION
Authors: Камышева С.Ю. , Филиппова А.А.
Published: March 2022

В статье представлен анализ состава мемориальной коллекции выдающегося лингвиста В.Г. Костомарова и сформулированы первоочередные задачи музея, посвященного биографии и деятельности ученого.

The article is aimed at presenting an analysis of the composition of the memorial collection of the outstanding linguist V.G. Kostomarov. In addition, the authors examine the priority tasks of the museum dedicated to the biography and activities of the scientist.
A benzimidazole derivative as an effective antitumor agent in terms of syngeneic lung tumors and melanoma treatment
Authors: Komarova E. F. , Morkovnik A. S. , Zhukovskaya O. N. , Verenikina E. V. , Shevchenko N. A. , Khodakova D. V. , Kurbanova L. Z. , Mindar M. V. , Zaikina E. V. , Galina A. V.
Published: March 2022

Purpose of the study. Evaluation of the effect of the benzimidazole derivative dihydrobromide‑2-(3,4‑dihydroxyphenyl)- 9‑diethylamino-ethylimidazo-[ 1,2‑a] benzimidazole (RU‑185) on the growth of Lewis lung epidermoid carcinoma and B16-F10 melanoma when administered intragastrically.

Materials and methods. For the experiment, we used female C57Bl/6j mice, which were inoculated subcutaneously with syngeneic tumors: Lewis lung carcinoma (LLC) and B16-F10 melanoma. RU‑185 was administered intragastrically to animals in a volume of 0.3 ml for 10 days, 1 time per day. For both tumors, depending on single doses of the substance for administration, groups were divided: 1st and 4th – 50 mg/kg, 2nd and 5th – 220 and 3rd and 6th – 500 mg/kg. The control groups were injected intragastrically with physiological saline in the same volumes and according to the same scheme. The following parameters were assessed: tumor volume, increase in life expectancy (T/S, %) and tumor growth inhibition index (TGI, %).

Results. For animals with LLC in the 2nd group there is an increase in the indicator of life expectancy (T/S 162.3 %), and in the 3rd group there is a tendency to an increase in the T/S indicator. On the 1st day after the end of treatment in the 2nd and 3rd groups TGI was 73.0 % and 30.1 %, respectively (р < 0.05). On the 7th and 14th days after the end of the use of RU‑185 in the 2nd and 3rd groups the volume of tumors is 3.5 and 1.4 times less (on the 7th day) and 2.3 and 1.3 times (on the 14th day), respectively than in the control group (р < 0.05). At a dose of 220 mg/kg, complete regression of LLC tumors was shown in 20 % of animals.

With the growth of B16-F10, the life expectancy of all groups did not differ. Intergroup differences in the dynamics of tumor growth are provided. Highlighted changes were found in the 5th group (on the 14th day after the end of the administration of RU‑185, TGI was 48.7 %).

Conclusion. The investigated chemical substance dihydrobromide‑2-(3,4‑dihydroxyphenyl)-9‑diethylamino-ethylimidazo- [1,2‑a] benzimidazole showed antitumor efficacy against syngeneic tumors: Lewis lung epidermoid carcinoma and B16-F10 melanoma when administered intragastrically which leads to further testing of RU‑185 as a potential drug for the treatment of malignant neoplasms.
Surgical treatment of retroperitoneal neuroblastoma in children. Clinical experience
Authors: Kuznetsov S. A. , Kolesnikov E. N. , Shevchenko A. N. , Kozel Yu. Yu. , Mkrtchyan G. A. , Starzhetskaya M. V. , Bespalova A. I. , Pak E. E. , Yurchenko D. Yu. , Popovyan O. P.
Published: March 2022

Purpose of the study. Was to analyze our experience of surgical treatment of retroperitoneal neuroblastoma in children and the influence of radical surgical treatment on the disease outcomes.

Materials and methods. The study included 35 patients (14 girls and 21 boys, mean age 3.3 years) receiving treatment for retroperitoneal neuroblastoma at the Department of Pediatric Oncology, National Medical Research Centre for Oncology, in 2016–2018. 32 patients underwent surgical treatment. The disease progression during neoadjuvant polychemotherapy was registered in 3 patients. Initially, surgery was performed in 5 patients; the rest of the patients underwent percutaneous trepan biopsy with immunohistochemical testing and subsequent neoadjuvant polychemotherapy. No patients developed complications in the early postoperative period. In the article, we present our experience in the surgical treatment of pediatric patients with retroperitoneal neuroblastomas.

Results. Patients have been observed during 12 to 24 months. 23 of 28 radically operated patients are alive and have no signs of the disease recurrence or progression. 2 patients developed tumor recurrence and received anti-recurrence PCT and DGT. Currently the patients are in remission. 3 patients showed systemic progression due to primarily advanced disease.

Conclusion. Administration of modern surgical techniques and instrumentation allows radical surgical treatment for a large percentage of patients with locally advanced neuroblastoma.
Markers of structural and cellular renal damage in localized renal cell carcinoma before treatment
Authors: Frantsiyants E. M. , Ushakova N. D. , Rozenko D. A. , Popova N. N. , Rozenko A. D. , Shulga A. V.
Published: March 2022

Purpose of the study. The purpose of the study was to analyze parameters of molecular markers of structural and cellular renal damage in localized renal cell carcinoma (RCC) with determining the nature of the initial abnormalities in the kidney functional state before the treatment.

Patients and methods. The study included 46 patients receiving elective surgical treatment for localized renal cancer in the Department of Oncourology, National Medical Research Centre for Oncology. The comparison group included the clinical and laboratory data of 13 healthy people comparable with the RCC patients in terms of age and gender. Cystatin C, IL‑18, KIM‑1, L-FABP, NGAL were determined in blood and urine in all patients.

Results. Evaluation of the kidney functional state of RCC patients showed that the initial values of serum creatinine and the glomerular filtration rate were similar to the reference levels in healthy people, but statistically significant differences were found in the ratios of cystatin C concentrations in the blood and urine in all patients, compared with normal values. Determination of L-FABP indices in RCC patients showed that their levels were 2.5 times higher than normal values, and the urine concentration of IL‑18 was 1.7 times higher than normal values (p < 0.05). Blood and urine levels of NGAL and KIM‑1 did not differ significantly from the comparison group.

Conclusions. The development of localized RCC is accompanied by the formation of tubulointerstitial dysfunction with impaired renal filtration capacity. All RCC patients showed elevated endogenous markers of structural and cellular renal damage – cystatin C, L-FABP, and IL‑18.
Potential of sonography in diagnosis of tongue tumors
Authors: Maksimova N. A. , Engibaryan M. A. , Ilchenko M. G. , Akopyan L. G. , Gurnak V. V. , Egorova A. S. , Cherkes M. A.
Published: March 2022

Purpose of the study. An analysis of sonography potential in the primary diagnosis and clinical staging of tongue cancer.

Patients and methods. The study included 18 patients aged 40–70 years with tongue tumors. The majority accounted males – 14 (77.7 %). Women were represented by 4 (22.2 %) examinees. Ultrasound examinations were performed using expert-class ultrasound systems with broadband linear multifrequency transducers. Transoral examination with linear transducers required tumor location in the anterior and lateral parts of the oral tongue. During ultrasound examinations we evaluated: tumor shape, tumor invasion depth; tumor sizes – width and thickness; tumor echogenicity and structure; tumor vascularization in Doppler modes. The results were compared with the data of histological examination.

Results. Transoral ultrasound examination of patients with tongue cancer allows clear visualization of the tumor and assessment of it’s spread. The study showed that the round shape of tongue tumors prevailed in 13 (72.2 %) patients, the tumor echo structure in 10 (55.5 %) was heterogeneous, the contours were even and clear in the majority of patients – 13 (72.2 %), all tumors showed a reduced acoustic density, the depth of invasion ranged from 2 to 6 mm in 8 (44.4 %) patients and exceeded 6 mm in 6 (33.3 %) patients, which corresponded to stages III and IV of the diseas. Doppler ultrasonography recorded intense intratumoral blood flow in 100 % of cases. In 8 (44.4 %) cases, metastatic lesions of the cervical lymph nodes were observed.

Conclusion. Transoral ultrasound diagnosis of tongue cancer is a highly informative, safe and modern method providing surgeons with information that helps in choosing the scope of surgical treatment and in determining the disease prognosis at the preoperative stage. The accuracy of the method was 87 %, the sensitivity was 85 %, and the specificity was 86.2 %.
Risk factors for deep vein thrombosis in patients with cerebral hemorrhage: a systematic review and meta-analysis
Authors:   Xiangtan Central Hospital, Hunan Province, Cheng Fangqun , Ye Biyun , Tang Ying , Xiao Zhuo , Liu Dan , Wang Ke , Cheng Peiyu , Zhang Jingping
Published: March 2022

Review question / Objective: To identify the risk factors of deep venous thrombosis in patients with cerebral hemorrhage. Eligibility criteria: Inclusion criteria: ①Comply with the “Guidelines for diagnosis of cerebral hemorrhage in China”[7] or “Guidelines for the management of spontaneous intracerebral hemorrhage in the United States”[37], or be diagnosed as ICH in combination with brain CT, MRI, and cerebral angiography; ②Age ≥18 years old; ③Ultrasonography or color polygraph Pler ultrasonography confirmed DVT; ④ The study type was cohort study or case-control study; ⑤ Newcastle-Ottawa Scale (NOS) [8] score ≥ 6 points; ⑥ The language was limited to Chinese and English. Exclusion criteria: ① Repeated publications; ② Studies without full text, incomplete information, or data extraction impossible.
Los perfiles del derecho de marcas en la posmodernidad
Authors: Cornejo Guerrero Carlos
Published: March 2022

El artículo tiene como objetivo establecer cuáles son los elementos fundamentales que configuran el derecho de marcas en la posmodernidad. Para ello se sigue una perspectiva histórica, llegándose a determinar que dicho perfil está conformado por un derecho de uso exclusivo sobre un signo, en el que, sin importar su naturaleza, evidencia una aptitud distintiva, actúa en un contexto global y se caracteriza por adecuarse a la riqueza de situaciones particulares que pueden darse en el mercado, a fin de evitar un aprovechamiento indebido del signo, sea nacional o internacionalmente.
La sentencia de la Corte Interamericana de Derechos Humanos en el caso del pueblo Saramaka vs. Surinam y el derecho de consulta a los pueblos indígenas
Authors: Bazán Chacón Iván
Published: March 2022

La cuestión planteada es si el derecho de consulta a los pueblos indígenas y tribales es conforme al Derecho internacional. Para solventar la pregunta se examina el marco constitucional peruano y su relación con el Derecho interno y el Derecho internacional en materia de derechos humanos. De esta relación derivan por ejemplo las obligaciones internacionales de nuestro Estado, vinculadas al sistema interamericano de protección de los derechos humanos, incluyendo las emanadas de la jurisprudencia de la Corte Interamericana de Derechos Humanos. A partir del análisis del Caso del Pueblo Saramaka vs. Surinam, se brinda un panorama a través de los fallos del Tribunal Constitucional e informes defensoriales de la Defensoría del Pueblo, ambos peruanos, para formular algunas conclusiones entre las que destaca el derecho de consulta a los pueblos indígenas y tribales conforme al Derecho internacional.
Prevalencia de caries dental en niños con dentición decidua usando índices ceo y el sistema internacional de detección y valoración de caries (ICDAS II)
Authors: Gálvez Ramírez Carlos
Published: March 2022

El propósito de este estudio fue determinar la diferencia entre los registros de prevalencia y los valores de índice de caries obtenidos a través de la utilización de ceo-d, ceo-s (estándar OMS) e ICDAS II. Un investigador previamente calibrado en ambos índices realizó exámenes clínicos para determinar la prevalencia y el índice de caries, en una muestra de 131 niños de 3 a 5 años de edad, aplicando los sistemas de registro señalados. El índice de piezas cariadas según los criterios del ceo-d fue de 4,1 y de 6,3 cuando se aplicaron los criterios ICDAS II. Las 2,2 piezas dentales de diferencia presentaban lesiones no cavitadas o “manchas blancas”. La prevalencia de caries fue de 83,97 % cuando se aplicó el índice ceo-d y de 92,37 % cuando se aplicó ICDAS II (p<0,001), encontrándose una diferencia en el registro de prevalencia de caries dental del 8,4 % y del 53,65 % en el promedio de piezas afectadas. El índice de superficies cariadas según los criterios del ceo-s fue de 7.9 y de 10.1 cuando se aplicaron los criterios ICDAS II; encontrándose una diferencia promedio del índice de 2,2 superficies; equivalente a una diferencia en el registro del promedio de superficies afectadas por caries dental del 27,84 %. Los resultados obtenidos muestran que se están dejando de diagnosticar aproximadamente 2 piezas dentales cariadas y entre 2 a 3 superficies dentales cariadas, las cuales dejan de ser atendidas en la etapa de mayor efectividad de la terapia preventiva.
Estudio comparativo de percepciones entre chilenos y peruanos, 2015. Informe preliminar de resultados de Lima-Perú
Authors: Hernández Lefranc Harold
Published: March 2022

El sentido común aplicado a la realidad, incluido el espacio público, social o político, está signado por criterios de nacionalidad. Es decir, complementariamente, por un lado, la percepción, criterio u opinión de las personas están condicionados históricamente por su nacionalidad, además de otros condicionantes —clase social, edad, sexo, región, profesión, nivel de politización, etc.—; y por otro, los filtros que conscientemente usan los individuos como categorías previas al acercamiento empírico a los otros individuos, suponen criterios de nacionalidad. Estos criterios de nacionalidad son históricamente construidos, y dependen de factores de cuya naturaleza finalmente los actores sociales no tienen una clara consciencia o no tienen ninguna.
COMBINED EFFECT OF YOGA AND NATUROPATHY ON PERCEIVED STRESS AND QUALITY OF LIFE IN UNCOMPLICATED VARICOSE VEINS - A PROSPECTIVE RANDOMIZED CONTROL STUDY
Authors: Chauhan Shweta , Patra Sanjib , Lakhani Jitendra D , Pradhan Balaram
Published: March 2022

Background- Despite of high prevalence, India reported very low incidence of varicose veins due to negligence, no reporting or late reporting. Among the treatment options, Yoga and Naturopathy can be one of the effective tool in managing varicose veins.
Objective- The presenting study evaluates the effectiveness of Yoga and Naturopathy intervention on perceived stress and quality of life in uncomplicated varicose veins (UVV).
Materials and methods- 50 UVV participants were randomized into two groups i.e. Experimental and control. Experimental group had undergone Yoga and Naturopathy interventions, whereas control group performed Passive exercises and Stretching. Data was recorded for EQ-5D-5L, PSS and SF-36 questionnaires at 30, 60 and 120 days of intervention.
Results- PSS- Perceived stress significantly reduced (p<0.001) on Day 30, 60 and 120 in experimental group, whereas the control group showed significant reduction (p<0.001) on Day 60 and 120. EQ-5D-5L- In experimental group, all the domains of descriptive EQ-5D-5L reduced significantly ( p<0.001), except “Usual activities” (p<0.01). EQ-VAS shows significant increase (p<0.001) at all time points. Control group shows no significant changes for any of the domain at day-30. On Day 60, only “pain/discomfort” reduced significantly (p<0.01) whereas on Day 120, significant reduction was observed in all the domains. EQ-VAS significantly improved at Day 60 and 120. SF-36-In experimental group, all the components increased significantly (p<0.001) at all points of time. In control group, no significant changes were observed for any domain at day-30. At Day-60, significant increase was observed in all the components. At Day-120, significant improvement in mean was observed for all the domains (p<0.001).
Conclusion- The results indicates that Yoga and Naturopathy intervention as well as passive exercise with stretching, both are effective in improving perceived stress and quality of life, but Yoga and Naturopathy have shown its efficacy in shorter duration of practice.
MANAGING EMOTIONS THROUGH SELF-TALK: MODERATING EFFECT OF DEMOGRAPHICS
Authors: Singh Vandana , Aggarwal Pooja
Published: March 2022

Regulating emotions has always been of great concern as it impacts mind and body of an individual tremendously. The concern over regulating emotions has become all the more important in the covid pandemic scenario. Current study attempts to address this issue by exploring the effect of self-talk on regulation of emotions among primary school teachers of North India. A sample of 529 primary school teachers represented the study and the study aims at determining the factors of self-talk and confirming them. Exploratory factor analysis run through SPSS 21 software contributed in determining the factors of self-talk and results of confirmatory factor analysis conducted through PLS adequately surpassed the measurement model criterion for self-talk and emotional regulation (ER) at higher order. Further, in order to understand the underlying relationship between self-talk and emotional regulation, structural model analysis was conducted through PLS-bootstrapping, which disclosed that self-talk has a significant positive effect in regulation of emotions with an R-square value of 44.2 per cent and a high effect size of 79.4 per cent. While the existence of moderation effect of selected demographics was checked through PLS-MGA after confirming the invariance among groups through PLS-MICOM. Its result revealed that self-talk is a significant tool in regulating emotions for all teachers irrespective of demographic frontier. Hence, the present study guide particularly teachers and people in general to use self-talk as a tool to overcome with their emotional turbulence and findings also provide direction to counsellor and psychologists to guide people in rerouting their emotions in a right direction.
Effect of Pursed Lip Breathing on Physiological Cost Index and Functional Exercise Capacity in Patients with Chronic Obstructive Pulmonary Disease
Authors:   Research scholar, Lecturer in Physiotherapy. Department of Physical Medicine & Rehabilitation, v, Parkavi K , Umarani R ,   Professor, Department of Medicine, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalai Nagar, Chidambaram, Tamilnadu, India – 608002., Anusha N ,   Department of Physical Medicine & Rehabilitation.  Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalai Nagar, Chidambaram, Tamilnadu, India – 608002., Rashika R ,   Department of Physical Medicine & Rehabilitation.  Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalai Nagar, Chidambaram, Tamilnadu, India – 608002.
Published: March 2022

Background: Pursed lip breathing (PLB) is known to improve oxygenation by controlled ventilation. In COPD, PLB is adopted as a compensatory mechanism to maintain the patency of airways by creating a back pressure in airways. Objective: To find the effectiveness of Pursed lip breathing (PLB) on Physiological cost index (PCI) and functional exercise capacity in patients having COPD. Study design: This experimental study was carried out with one group pre test - post test design. Procedure: Thirty patients aged above 45 years and diagnosed as having mild and moderate COPD (as per GOLD staging) were assessed for their PCI and functional exercise capacity by six- minute walk test after their informed written consent. They were given 30 minutes of PLB training for 5 consecutive days. The post-interventional PCI and functional exercise capacity were reassessed. Results: The pre and post-intervention data of outcome measures was statistically analyzed using paired-t test. The results showed significant improvement in PCI and the functional exercise capacity. Conclusion: Pursed lip breathing was found to be more effective in improving Physiological Cost Index and six-minute walk performance in patients with mild to moderate COPD. Hence, it has been suggested to train pursed lip breathing voluntarily at early stages of COPD before the patient adopts it as compensatory mechanism on advanced stages
The Type Icn SN 2021csp: Implications for the Origins of the Fastest Supernovae and the Fates of Wolf–Rayet Stars
Authors: Perley Daniel A. , Sollerman Jesper , Schulze Steve , Yao Yuhan , Fremling Christoffer , Gal-Yam Avishay , Ho Anna Y. Q. , Yang Yi , Kool Erik C. , Irani Ido , Yan Lin , Andreoni Igor , Baade Dietrich , Bellm Eric C. , Brink Thomas G. , Chen Ting-Wan , Cikota Aleksandar , Coughlin Michael W. , Dahiwale Aishwarya , Dekany Richard , Duev Dmitry A. , Filippenko Alexei V. , Hoeflich Peter , Kasliwal Mansi M. , Kulkarni S. R. , Lunnan Ragnhild , Masci Frank J. , Maund Justyn R. , Medford Michael S. , Riddle Reed , Rosnet Philippe , Shupe David L. , Strotjohann Nora Linn , Tzanidakis Anastasios , Zheng WeiKang
Published: March 2022

We present observations of SN 2021csp, the second example of a newly identified type of supernova (SN) hallmarked by strong, narrow, P Cygni carbon features at early times (Type Icn). The SN appears as a fast and luminous blue transient at early times, reaching a peak absolute magnitude of −20 within 3 days due to strong interaction between fast SN ejecta (v ≈ 30,000 km s−1) and a massive, dense, fast-moving C/O wind shed by the WC-like progenitor months before explosion. The narrow-line features disappear from the spectrum 10–20 days after explosion and are replaced by a blue continuum dominated by broad Fe features, reminiscent of Type Ibn and IIn supernovae and indicative of weaker interaction with more extended H/He-poor material. The transient then abruptly fades ∼60 days post-explosion when interaction ceases. Deep limits at later phases suggest minimal heavy-element nucleosynthesis, a low ejecta mass, or both, and imply an origin distinct from that of classical Type Ic SNe. We place SN 2021csp in context with other fast-evolving interacting transients, and discuss various progenitor scenarios: an ultrastripped progenitor star, a pulsational pair-instability eruption, or a jet-driven fallback SN from a Wolf–Rayet (W-R) star. The fallback scenario would naturally explain the similarity between these events and radio-loud fast transients, and suggests a picture in which most stars massive enough to undergo a W-R phase collapse directly to black holes at the end of their lives.
Compositional Maps of the Lunar Polar Regions Derived from the Kaguya Spectral Profiler and the Lunar Orbiter Laser Altimeter Data
Authors: Lemelin Myriam , Lucey Paul G. , Camon Alex
Published: March 2022

Due to the challenging illumination conditions of the lunar polar regions, mineralogic maps have generally been constrained to within 0°–70°N/S. Here we generate a gridded reflectance data cube from the Kaguya Spectral Profiler measurements for each polar region and calibrate it to absolute reflectance using data from the Lunar Orbiter Laser Altimeter. We use this data set to derive the first quantitative mineral maps of iron oxide (FeO), the optical maturity parameter (OMAT), and nanophase iron poleward of 50°N/S at a spatial resolution of 1 km pixel–1. We evaluate potential latitudinal trends in space weathering and optical maturity and characterize the polar geology, with an emphasis on the Artemis region (84°–90°S). The maps of FeO are in excellent agreement with the abundances measured by the Lunar Prospector and provide an increased level of detail, such as the excavation of high- and low-FeO material by De Forest crater. The OMAT maps offer a fantastic view of both polar regions. They highlight small fresh craters, walls, and central peaks, as well as rays extending through multiple degrees of latitude, such as those from Tycho and De Forest, which extend into the Artemis region. Both polar regions are characterized by the ubiquitous presence of noritic anorthosites and anorthositic norite. Low-calcium pyroxene is largely the dominant mafic mineral present. The Artemis region has relatively homogeneous FeO and plagioclase content at the observed spatial resolution. The lowest FeO values are found near Shackleton, between Shoemaker and Faustini, and on the central peak of Amundsen crater.
Ceftazidime-avibactam plus metronidazole vs. meropenem in complicated intra-abdominal infections: Indian subset from RECLAIM
Authors: Rodgers Prithi , Kamat Shweta , Adhav Charles
Published: March 2022

Introduction: This study analyzes the safety and efficacy results of the Indian population subset from the RECLAIM trial investigating the non-inferiority of Ceftazidime-Avibactam (CAZ-AVI) plus metronidazole to meropenem and interprets its relevance.

Methodology: The study design, subjects inclusion criteria, dosage, safety and efficacy evaluations in Indian patients have been followed as per the RECLAIM trial protocol.

Results: A total of 142 Indian patients with complicated intra-abdominal infection were enrolled across eight centers in India, 125 of them were randomized to either CAZ-AVI + metronidazole (n = 62) or meropenem (n = 63) group. the clinical cure rates in modified intention-to-treat (MITT; all randomized patients who met minimum disease requirements and received any amount of study drug) and clinically evaluable (CE , patients who had an evaluable assessment and no protocol deviations) analysis sets, was numerically comparable to the results of overall population for CAZ-AVI + metronidazole [MITT: 82.5% (Overall, n = 429/520) versus 89.3% (Indian, n = 50/56); CE: 91.7% (Overall, n = 376/410) versus 97.8% (Indian, n = 45/46)] and meropenem [MITT: 84.9% (Overall, n = 444/523) versus 84.7% (Indian, n = 50/59); CE: 92.5% (Overall, n = 385/416) versus 95.5% (Indian, n = 42/44)]. No new safety findings were reported in the Indian population.

Conclusions: CAZ-AVI + metronidazole proved to be an effective option for critical patients with complicated intra-abdominal infection and can be considered as an alternative to carbapenems in the ICU setting for the treatment of resistant pathogens.
Factors associated with prolonged viral detection in asymptomatic and mildly symptomatic patients with SARS-CoV-2 infection
Authors: Lee Yong Hoon , Hong Chae Moon , Lee Taek Hoo , Hwang Yoon Jin , Kim Dae Hyun , Lee Jaetae
Published: March 2022

Introduction: Data on the clinical course and duration of viral RNA detection in patients with mild or asymptomatic coronavirus disease 2019 are limited.

Methodology: In this retrospective analysis, clinical characteristics and serial real-time reverse transcriptase-polymerase chain reaction (RT-PCR) results were reviewed in a cohort of 1186 asymptomatic and mildly symptomatic coronavirus disease 2019 patients in South Korea. Factors associated with prolonged duration of RT-PCR positivity for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) were also evaluated. Patients with two consecutive negative RT-PCR tests ≥ 24 hours apart were considered to be in virologic remission and discharged.

Results: The average virologic remission period, defined as the number of days from diagnosis to virologic remission, was 22.0 ± 9.7 days; patients with longer than 30 days accounted for 21.2% (251/1186) of the population. Patients who took longer than 30 days to achieve virologic remission had a higher frequency of overall symptoms (p < 0.001) and respiratory symptoms (p < 0.001). In multivariate analysis using Cox-proportional hazard regression, it was confirmed that respiratory symptoms (hazard ratio [HR], 0.7372; 95% confidence interval [CI], 0.6540-0.8311) and gastrointestinal symptoms (HR, 0.8213; 95% CI, 0.6970-0.9679) were independent factors associated with prolonged virologic remission. Age and co-morbidity such as diabetes and hypertension were not associated with the prolonged RT-PCR positivity.

Conclusions: A considerable percentage of asymptomatic and mildly symptomatic patients with coronavirus disease 2019 showed prolonged RT-PCR positivity for SARS-CoV-2; which was independently associated with the presence of symptoms, but not with age and co-morbidity.
Sphingomonas paucimobilis infection in subcutaneous abdominal preservation of bone flap after craniotomy
Authors: Rinawati Weny , Kumalawati July
Published: March 2022

Introduction: Sphingomonas paucimobilis, previously known as Pseudomonas paucimobilis, is a Gram-negative rod. It is emerging as an opportunistic pathogen that can infect individuals in community or hospital settings. It is believed that the natural habitat of this organism is soil and water, including water sources in the hospital environment.

Case report: We describe the case of a 46-year-old patient in whom S. paucimobilis was identified in the implanted bone flap after craniotomy. The postoperative bone flap was implanted in the right hypochondria and replaced after 8 weeks. There was a hypochondriac abscess in the area under the bone. Specimens from the thickened fascia and bone flap were cultured. The Gram stain showed Gram-negative rods and these rods were identified as S. paucimobilis. The patient was treated with a combination of Gentamicin 240 mg and Levofloxacin 750 mg once daily because the bacteria were resistant to carbapenem, trimethoprim-sulfamethoxazole, and anti-pseudomonal penicillin.

Conclusions: Although S. paucimobilis characteristically presents low virulence, for better patient management and outcome, the diagnosis should be immediately followed by appropriate antibiotic therapy guided by susceptibility test results of each case.
A case of disseminated BCG infection in a daughter of Italian immigrants in Switzerland
Authors: Colomba Claudia , Rubino Raffaella , Tolomeo Manlio , Lo Porto Davide , Bonura Silvia , Agrenzano Stefano , Cascio Antonio
Published: March 2022

Bacillus Calmette-Guérin (BCG) is a vaccine against tuberculosis and contains a live, attenuated strain of Mycobacterium bovis as its essential constituent. Being a live, attenuated strain with potential pathogenicity, BCG can cause different complications, both near the inoculation site and through blood dissemination, especially in patients with immunodeficiency. IFN-γR1 deficiency is an autosomal recessively inherited immunodeficiency characterized by predisposition to infections with intracellular pathogens, in particular mycobacteria.

We report a rare case of chronic osteomyelitis lasting 30 years due to BCG in a woman with IFN-γR1 deficiency who had previous clinical history of multi-organ BCGitis. Diagnosis of chronic osteomyelitis was confirmed by an 18-fluorine fluorodeoxyglucose positron emission tomography combined with CT scan (18F-FDG PET/CT).

In children with a history of BCG vaccination and chronic unexplained infections, a clinical suspicion of BCG-related disease must arise, and a reason of immunodeficiency should be sought.
The Effectiveness of Pre-operative Bath with 4% Chlorhexidine Gluconate for Prevention of Surgical Site Infection at the Universitas Sumatera Utara Hospital
Authors: Prayugo Bambang , Siregar Afrinayanti , Hutahaean Lenny , Hasibuan Mirzan
Published: March 2022

Introduction: Elective surgery is a type of surgery that can be postponed or planned without endangering the patient's life. Every operation, the slightest, can pose a risk of infection. Surgical site infection (SSI) is still a global problem that can increase morbidity and mortality rates, prolong the time and cost of hospitalization. Chlorhexidine Gluconate (CHG) 4% is an antiseptic with broad-spectrum antimicrobial ability that can be used as an effort to prevent SSI.
Aim: This study aims to analyze the effectiveness of preoperative antimicrobial baths using 4% CHG in an effort to prevent the incidence of SSI in Universitas Sumatera Utara hospitals.
Methods: The design used in this study was a quasi-experimental method with a nonequivalent control group posttest only design method. The total sample in this study was 60 respondents according to the inclusion criteria. Bivariate analysis using Chi-square statistical test.
Results: A total of 60 samples that met the research criteria were then divided into the preoperative bath intervention group with 4% CHG (n = 30) and the control group was not given any treatment (n = 30). In the preoperative bath intervention group with 4% CHG, there was no incidence of SSI, while in the control group, 5 (n=8.3%) respondents experienced SSI. Preoperative bath with 4% CHG was statistically more effective than not given preoperative bath with 4% CHG in preventing the incidence of SSI (p = 0.02).
Conclusion: Preoperative bath with 4% CHG is effective in preventing SSI because 4% CHG is bactericidal, bacteriostatic, lasts a long time on the skin thereby reducing the number of bacterial colonies nine times and increasing the skin's ability to be antiseptic for longer.
Adequate Vitamin A Levels with Stunting Adolescents of Minangkabau Ethnicity in Indonesia: A Case-Control Study
Authors: Usman Elly , Masrul Masrul
Published: March 2022

Background: Stunting is a type of linear growth condition. The release of growth hormone in long bones can be hampered by a lack of micronutrients such as vitamin A. This study was performed to determine adequate vitamin a levels with stunting adolescents of Minangkabau ethnicity in Indonesia.
Methods: A case-control study was used in this study. This study was undertaken at several senior high schools in Padang, Indonesia. Stunting adolescents aged 16 to 18 years of Minangkabau ethnicity were included in the study. Adolescents with stunting were in the case group, whereas those who did not have stunting were in the control group. The age and sex of the cases and controls were matched. There were 42 cases and 42 controls in the research. Vitamin A measurement used SQ-FFQ. The Independent sample T test and the Chi-square test were used to analyze the data. Statistical significance was defined as a two-tailed p-value < 0.05. GraphPad Prism 7.00 program was used to gather and analyze data.
Conclusion: Our research found that stunted adolescent of the Minangkabau ethnic group in Indonesia have low vitamin A levels.
The Consumption of Yellow Watermelon-plantain Juice before Anaerobic Exercise Improves Blood Glucose and Suppresses Oxidative Stress Formation in Rats
Authors: Sulistyaning Afina , Farida Farida , Sari Hesti
Published: March 2022

Food supplementation prior to exercise could supply glucose for energy booster and enhanced performance. Food supplements with potent antioxidant activity could also help alleviate oxidative stress formation during exercise. This study aiming to investigate yellow watermelon-plantain juice administration prior to anaerobic exercise on blood glucose level and its protective effect on markers of oxidative stress formation that is malondialdehyde (mda) serum level. Thirty-five male Sprague Dawley rats were divided into five different groups in which received different treatments. Anaerobic exercise in this study was set as swimming test for three minutes. Blood glucose level were examined as baseline, thirty minutes after juice supplementation, and after exercise test. P2 groups has the highest blood glucose level before and after exercise (111.86 mg/dl and 100.52 mg/dl, respectively). Mda level after exercise differ significantly between groups (p < 0.05) with negative control group has the highest level of Mda (7.68 nmol/ml) and P2 has the lowest level among treatment groups (1.8 nmol/ml). It can be concluded that yellow watermelon-plantain juice supplementation prior to anaerobic exercise is an effective source of energy due to its rapid glucose availability in the serum. Antioxidant content in yellow watermelon-plantain juice could also suppressed malondialdehyde serum level after exercise