bluuebunny/crossref_metadata_2025 huggingface dataset:
The themes of works of Bessarabian painters between 1888-1917
Authors:   Institute of Cultural Heritage, Republic of Moldova, Stavila Tudor
Published: August 2021

The themes and subjects approached by the plastic artists, in a certain period of time, in a certain geographical space, including the names of the works, indirectly reflect the existing tendencies in the respective epoch. These moments are indisputable, regardless of the evolutions of art in various cultural environments, in the centers of international art or on its peripheries, objectively reflecting the styles and priorities of the time. Thus, realism operates with certain terms that define the options of the current, different from those of impressionism, expressionism, etc. The Bessarabian visual arts are no exception in this case. More refractory and more specific, the evolution of local culture was due to the historical situation of the land, ruled by the Tsarist Empire for a century, with the late emergence of professional art and the direct influences of Russian and Ukrainian itinerants’ realism characterized by special themes. But these trends were also marked by the emergence of non-conformist representatives of Russian art, such as Vladimir Falileev, Alexander Shevchenko, Nathan Altman, participants in Bessarabian salons in the early twentieth century. More eloquently, these renewals of local art occur after the internship of Eugenia Maleshevsci in Europe, the sporadic return to the homeland of Pavel Shilingovschi, but also the appearance in Bessarabia of a true representative of the new currents, such as Auguste Baillayre.
The cultural heritage of Chisinau in 1930–1950
Authors: Ильвицкая Светлана, , Поян Анна
Published: August 2021

One of the trends in the development of tourism is the appearance of open-air museums, which are the hallmark of a museum and tourist destination. On the example of the central quarters of Chisinau, the exhibits of the open-air museum can be architectural monuments of the interwar period – preserved urban villas of 1930-40, which combine the characteristic features of Art Nouveau, functionalism, modernism and Neo-Romanian architecture. As world experience shows, the best results in the popularization of historical and cultural heritage are achieved by specially protected historical territories, where new types of museums are organized – air museums or open-air museums. Such an example is the unrealized projects of the 1980s “The Ethnographic Museum of the Moldavian village” and “The Historical Quarter “Pushkinskaya Gorka”. The article examines the three-axis method of “triluchya” as a cultural heritage of urbanism, which was addressed in the post-war years (1945-1948) by the Academician of Architecture A. Shchusev when working on a project proposal - the scheme of the general plan for the development of the city of Chisinau. His idea of enriching the expressiveness of the city was to synthesize the planning traditions of historical neighborhoods while solving the problem of preserving the plasticity of the existing building and its further development.
From Idea to Realisation: The architecture of Jovan Stefanovsk
Authors: Bianco Lino
Published: August 2021

Although not widely acknowledged, the Republic of North Macedonia boasts a number of prolific architects who were often engaged in architectural education. Jovan Stefanovski, the author of the Millennium Cross and the National Theatre, both in the capital Skopje, is one such personality. Similar to former generations of architects, his design style conceptually recalls the traditional architecture of his homeland. Researching the Jovan Stefanovski Archive, a number of projects were identified – a sample from the case-studies covered in his doctorate thesis – and discussed with respect to the themes of ‘idea’ and ‘realisation’ in architecture. His notion of the former is akin to ‘concept’ as used in architectural design. While an idea is an expression of the unconscious, realisation is the conscious decision to execute the design idea. Stefanovski was a prolific architect and educator. His interest in traditional architecture was in line with the trends which developed in the late 1960s and early 1970s. Furthermore, in line with the architectural approaches being developed by Stefanovski’s teachers, the regionalist idiom which emerged in Macedonia, is contemporaneously evident in his work both in form and function.
Satirical graphics in the creation of the plastic artist Iurie Rumeanțev
Authors:   Technical University of Moldova, Adascalita Lucia
Published: August 2021

d cultural barometer, it highlighted the perception and plastic reflection of events and changes typical of the weather. Quite a few plastic artists contributed to this, among whom the graphic artist Iurie Rumeanțev. The artist showed skill, artistry and originality in the perspective of emphasizing some interesting facets of everyday life. During his creative activity, the artist creates numerous satirical sheets that see the light of day in various publications, including the satire and humor magazine "Chipăruș", the magazine "Femeia Moldovei", the newspaper "Tinerimea Moldovei", etc. Frequently participating in international exhibitions, Iurie Rumeanțev is appreciated with diplomas and medals both for his caricatures and for his book graphics. Artistically reflecting the social life of the era in which he worked, Iurie Rumeanțev managed to create valuable graphic sheets in which, situations, frequently encountered in everyday life, are mirrored in an ironic way. At the same time, the artist excludes distortions of shape and hideousness in the representation of the characters, emphasizing the artistic revelations of the human essence. Simultaneously with the satirical graphics, Iurie Rumeanțev also manages to persevere in book graphics by making reference works.
Some issues on the development of digital art in the Republic of Moldova
Authors:   Institute of Cultural Heritage, Republic of Moldova, Kravcenko Vladimir
Published: August 2021

The paper examines the creative segment of digital art, which has been carried out by professional graphic artists in the independent Republic of Moldova, including finished artworks produced in big and small print runs, and also unique graphic works. Sketches and technical drawings of any kind are excluded from the study. Important data is provided about different images (chiesel works, book illustrations, caricatures, postage stamps, ex-librises), which were rendered digitally both in full and in part. Also, concise information is offered on the professionals practicing the respective type of digital art over the years. There is also contoured the process of nationwide spread of the digital images and the specifity of the digital creative tool. The author also examines the professional attitude towards digital art in the Republic of Moldova in terms of the relationship between mass production, traditional handmade art and digital execution technique. The reasons and conditions for the dissemination of digital images in national art are specified. The dynamics of opinions on the role of the computer in the creation and modification of graphic works at different stages of the evolution of digital and traditional technology in the Republic of Moldova is traced.
Formation of new approaches to the research practice and preservation of architectural and archaeological monuments of the North Black sea area (Comparative castellology and digital technologies)
Authors: Беляева Светлана , Коцюбанская Ольга , Куценко Сергей
Published: August 2021

The article is dedicated to the investigation of the current tasks of the modern study and preservation of the architectural and archaeological heritage of the peoples of Eastern Europe in the North Black Sea area based on comparative castellology and digital technologies. The comparative analysis of two outstanding monuments - the Belgorod fortress in the western part of the region and the Tyagin fortress in the eastern part, which historically go back to the history of the Moldavian and Grand Lithuanian principality of the XIV-XV centuries, is made and general trends and features in the planning structure and the architecture of the monuments are considered. The positive results of the work of scientific teams, representing scientists from different countries of the world united by special projects to study outstanding monuments, the use of modern methods of studying architectural complexes, including modeling individual objects and creating computer models of monuments in general, are presented. Questions were raised about the need for joint efforts for the preservation and tourist use of the cultural heritage, the development of good neighborly relations between the countries of the Black Sea region and Europe as a whole.
Architectural and Historic-Geographical Mystery of the Church of Vasilcau Village
Authors: Нестерова Тамара , Герцен Андрей
Published: August 2021

The article provides a comprehensive architectural and historical-geographical analysis of a unique monument of medieval religious-defensive architecture – the Church of the Assumption of the Virgin in Vasilcau village, located on the banks of the Dniester River, near the state border of the Republic of Moldova and the Ukraine. Vasilcau was the border point between the Principality of Moldavia and the Grand Duchy of Lithuania in the Middle Ages. Its geographical position led to the formation of a fortified border point here, which served as an eastern outpost of the Soroca tsinut (county). The elevated cape with steep slopes, on which a temple with a bell tower, a courtyard, a trading square, as well as an ancient trade road and a river crossing was built, is a vivid example of a natural, historical-cultural complex, the basis of which is a medieval fortified point with a unique cult-defensive monument of architecture. The church represents a widespread type of place of worship, whose architecture combines the planimetric features of wooden architecture with those used in medieval buildings built of stone, highlighted in the found proportions. The solution of the historical-geographical enigmas that envelop the history of the heritage monument in the absence of written sources is carried out on the basis of a complex poly-scale historical and cartographic analysis and the use of modern geoinformation methods.
Alexei Colîbneac’s series of self-portraits
Authors:   Institute of Cultural Heritage, Republic of Moldova, Sibaev Dmitri
Published: August 2021

Alexei Colîbneac is one of the notorious graphic designers of the national art. Many distinctions and the presence of works in important public collections are proof of the artist’s mastery and of the intellectual message of his artistic discourse. In his imposing creation, we notice numerous series of drawings; one of them being the series of self-portraits, which was not exploited in theoretical studies. Researching the history of value appreciation of the artist’s creation, we found an impressive number of periodicals and publications, but too few scientific. In the series of self-portraits, on which the artist worked at different stages of his life, we see the author in a wide variety of states of mind and spirit. Based on these works, we trace the formation of the artist’s personality: from adolescence, youth, to maturity, in which A. Colîbneac fully demonstrates the ability to ask complex questions of an existential nature or to show slight self-irony, drawing some compositions as if joking. The drawings are made in various techniques of graphics, also the artist uses different languages for dealing with form and space, in some works strictly linear, in others using chiaroscuro. When the observer and the subject are the same person, the spectator witnesses an intimate monologue that constitutes an act of self-knowledge through plastic language.
The expression and biological function of DKK1 in oral squamous cell carcinomas by bioinformatics analysis
Authors:   Department of Stomatology, The People’s Hospital of Dongying, Shandong, China, Yu Huijie , Li Tianhua ,   Department of Stomatology, The People’s Hospital of Dongying, Shandong, China, Mao Xuemei ,   Department of Stomatology, The People’s Hospital of Dongying, Shandong, China
Published: August 2021

Objective: To clear the expression of transcription factor Dickkopf-1 (DKK1) in Oral Squamous Cell Carcinoma (OSCC) using the method of bioinformatics analysis. And to clarify the relationship between the expression of DKK1 and the clinicopathological characteristics of OSCC using the method of molecular biology and cytobiology, in order to determine the early diagnosis and significance of OSCC according to the marker of DKK1. Methods: In this study, the expression level of DKK1 in OSCC tissues was analyzed using GEPIA and TCGA databases, and then verified in vitro by qRT-PCR and Western-blot analysis. The correlation between DKK1 gene expression and the clinical pathological parameters of OSCC, and also the impact of DKK1 on prognosis were determined using the Linked Omics database. In addition, DKK1 was knocked down by RNA interference in SCC-4 and SCC-25 OSCC cell lines and the proliferation ability of OSCC cells was assessed by MTT assay. Results: High expression of DKK1 in OSCC is positively correlated with the pathological grade and T stage of OSCC. According to the TCGA results, DKK1 mRNA was highly expressed and it is related to the overall survival rate of OSCC. In addition, the expression level of both DKK1mRNA and protein were significantly raised in the cell line SCC25 and SCC-4. Furthermore, MTT analysis showed that DKK1 knockdown resulted in reduced proliferation of OSCC cells. Conclusions: TCGA database analysis showed that DKK1 was highly expressed in OSCC, and it is closely correlated to the pathological parameters of OSCC, which will provide important theoretical guidance for the subsequent study of oral squamous cell carcinoma.
A sign of spinal cord stroke. Vertebral body ischemia
Authors:   Image Diagnostic Institute, Section of Neuroradiology, Arnau de Vilanova University Hospital, University of Lleida, Lleida, Spain, Mitjana Raquel , Mauri-Capdevilla Gerard ,   Stroke Unit, Department of Neurology, Arnau de Vilanova University Hospital, University of Lleida, Lleida. Spain, Purroy Francisco ,   Stroke Unit, Department of Neurology, Arnau de Vilanova University Hospital, University of Lleida, Lleida. Spain, Vázquez-Justes Daniel Vázquez-Justes ,   Stroke Unit, Department of Neurology, Arnau de Vilanova University Hospital, University of Lleida, Lleida. Spain, Vicente-Pascual Mikel ,   Stroke Unit, Department of Neurology, Arnau de Vilanova University Hospital, University of Lleida, Lleida. Spain
Published: August 2021

Spine cord infarction is a rare neurological disease. The MRI can show T2 hyperintense signals, and these lesions can be associated with a vertebral body lesion, that supports the ischemic etiology. We present a 54 year-old-woman with an acute spinal cord syndrome, with a final diagnosis of spinal cord infarction. The initial MRI showed no abnormalities, but a second MRI showed increased signal intensity in T2 sequences and DWI, with a decreased in ADC maps, all compatible with an ischemic lesion. Moreover, the MRI revealed a T2 hyperintense signal in adjacent vertebral body, compatible with ischemic nature. Spine cord MRI is an important complementary exploration in the diagnostic of myelitis syndrome. Other sequences, such as diffusion, should be included, as well as consider the coexistence of a lesion in the adjacent vertebral body, which can support the ischemic etiology of the symptoms.
Development of bladder plate calculus on missed sutured surgical sponge following primary bladder exstrophy repair
Authors:   Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran, Zolbin Masoumeh Majidi , Matin Leila Moradi ,   Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran, Bitaraf Masoud ,   Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran, Gashti Reza Nejad ,   Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran, Sabetkish Shabnam ,   Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran, Kajbafzadeh Abdol-Mohammad ,   Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Published: August 2021

Bladder Exstrophy (BE) has been considered as a rare congenital malformation of the genitourinary system, with an estimated incidence of approximately 1 per 50,000 live births [1]. The management of this anomaly is complex, involving several surgical reconstructions with numerous challenges to achieve anatomically, functionally, and cosmetically satisfactory outcomes [2]. Furthermore, the management must be early in the first months of life for better functional and cosmetic results [3,4]. Wound dehiscence, urethral outlet obstruction, bladder prolapsed, renal and bladder calculi are among the main complications following failed primary BE closure [5]. Urinary stone formation is estimated to be around 15% following bladder closure, in repaired BE patients, especially in cases living in poor or rural regions [6]. Bladder stone formation may occur following infra-vesical obstruction, neurogenic voiding dysfunction, urinary tract infection, foreign bodies, and metabolic risk factors years after reconstructive surgery [7]. Here, we report a 6-yearold boy with failed BE repair at an early age that was complicated by late surgery outcomes and secondary stone formation on missed sutured surgical sponge post-operatively.
Complicated intra-abdominal focal fat infarction: Emphasis on falciform ligament infarction with abscess formation: A case series
Authors:   Columbia Asia Hospital, Whitefield, Bangalore, India, Monteiro Berton , Joshi Saurabh ,   Columbia Asia Hospital, Yeshwanthpur, Bangalore, India, Gopalan Sunita ,   Columbia Asia Hospital, Yeshwanthpur, Bangalore, India, Hanumaiah Ravikumar ,   SUNY Upstate Medical University, Syracuse, New York, USA
Published: August 2021

The term “Intra-Abdominal Focal Fat Infarction” (IFFI) encompasses a range of conditions where infarction of fatty tissue is the underlying pathological process, including Epiploic appendagitis, omental infarction, fat necrosis related to trauma or pancreatitis as well as rarer entities such as falciform ligament infarction. Uncomplicated IFFI is usually self-limiting and managed conservatively with oral antiinflammatory therapy. Rarely complications such as liquefaction and secondary abscess formation may arise with associated deterioration in symptoms and signs prompting a change in management including Laparoscopic resection or Percutaneous drainage. We present 3 cases of complicated IFFI with emphasis on the rarer Falciform ligament infarction with abscess formation.
Strateji Düşüncesinde Yorum ve Tahrifat: Clausewitz Olayı
Authors: KARAOSMANOĞLU Ali
Published: August 2021

Modern Strateji Teorisinin ortaya çıkması 19.yy’ın ilk yarısında teori ve tarih arasındaki ilişkilerin diyalektik bilim felsefesi zemininde yorumlanması ile ortaya çıkmıştır. Bu dönüşümün askeri ve siyasi alandaki öncüleri Prusyalı askeri reformcular ve Carl von Clausewitz’dir. Fakat söz konusu öncü çalışmalar dikkatle okunarak yorumlanmamış, tahrif edilerek ve okuyucuların önyargıları öne çıkartılarak anlaşılmış ve uygulanmıştır. Hatalı anlayışlar ve kasıtlı yanlış yorumlar İkinci Dünya Savaşı’nın sonuna kadar önemli ölçüde devam etmiştir. Soğuk Savaş’ta doğru ve doğruya yakın yorumlar ve uygulamalar ağırlık kazanmaya başlamıştır. Osmanlı modernleşmesi ve Cumhuriyet Türkiye’si de yanlış yorumların büyük ölçüde etkisinde kalmıştır. Fakat uygulama alanında bunun tek istisnası Mustafa Kemal Atatürk ve arkadaşlarının yönetme ve davranışlarıdır.
Kırım ve Osmanlı-Rus Savaşları Arası Dönemde Canlanan Kültürel Hayat (1853-1878 )
Authors: ÖZCAN Ahmet
Published: August 2021

Türkiye’nin yakınçağ tarihinin yazımı genellikle modernleşme paradigmasından etkilenmiş, reformlara odaklı inkılap tarihçiliğinin etkisi altında kalmıştır. Siyasal aktör ve onların faaliyetlerini önceleyen bu tarih yazımı özellikle kültür tarihi çerçevesinde ele alınabilecek birçok olguyu ve bu olguların ortaya çıktığı süreci dikkate almamış veya aktörleri merkeze alarak açıklamaya çalışmıştır. Dolayısıyla savaşlar ve onların siyasal, toplumsal, kültürel sonuçları da bu merkeze bağlı olarak açıklanmaya çalışılmıştır. Esasında birçok anlamda büyük bir değişim ve fark edilir derecede ilklerin görüldüğü 1860-1880 arası dönem Tanzimat ve Islahat gibi daha çok siyasal dönüşümü çağrıştıran kavramların gölgesinde kalmıştır. Bu kavramlar da kurumsal ve toplumsal değişimin önünü açan reformların yukarıdan aşağıya doğru uygulanmasına işaret etmektedir. Oysa bu çalışmada verilen örneklerden anlaşılacağı üzere resmi alanın dışında kalan ve resmi alanlarda bir ihtiyaç olarak doğan değişimlerin yanı sıra sivil alanların aşağıdan yukarıya doğru değişimi zorlayan etkisi büyüktür. Uluslararası bir ittifakla girişilen ilk harbin merakları cezbeden sürecinin sivil basın ve yayıncılığı zorunlu bir ihtiyaca dönüştüren sonucu olmuştur. Harbin yıkıcı etkilerinin yanı sıra siyasal, toplumsal ve kültürel dinamizm kazandıran ve değişimi zorlayan sonuçları da görünmektedir. Kırım ve Osmanlı-Rus Harbi arasında kalan zaman dilimi bu anlamda dikkate değer birçok örnek içermektedir. Bu dönem birçok anlamda ilklerin yaşandığı bir atmosfer olmuştur.
Nerve lesions during arthroscopic procedure: a literature overview
Authors: Amadei Federico , Basile Giuseppe , Leigheb Massimiliano
Published: August 2021

Arthroscopy is more and more popular. Although minimally-invasive, it’s not completely free of complications as nerves lesions which can be invalidating for the patient and frustrating for the surgeon with significant economic, psychological and medico-legal implications.

The purpose was to review the literature about nerve injuries related to arthroscopy.

A scientific literature review was performed in PubMed/Medline, including articles dealing with cases of iatrogen lesions of the peripheral nerves occurred during arthroscopic procedures.

These lesions are mainly due to direct damage by nerve section while cutting for making the portals or during surgical maneuvers, or indirect damage due to traction or pressure mechanisms especially for errors in patient positioning. Also the tourniquet can lead to compression and ischemic nerve injury. Arthroscopy can cause both transient and permanent neurological lesions manifested with dysesthesia up to paralysis according to Seddon’s classification in neuroapraxia, axonotmesis and neurotmesis. Incidence of complications in general and of nerve injuries during arthroscopy are reported by joint.

A rigorous respect for surgical technique and all perioperative precautions, particularly in relation to the positioning of the patient, greatly reduce the risk of nerve injury.

The suggested waiting time before surgical nerve revision is 6 months. In the meanwhile the patient should perform physiotherapy constantly and improvements should be evaluated with clinical examination and electromyography 15-20 days after the lesion, and thereafter at 3 and 6 months.
Ketamine for the Treatment of Chronic Pain: A Comprehensive Review
Authors: Israel Jacob E. , St Pierre Samantha , Ellis Emily , Hanukaai Josephine S. , Noor Nazir , Varrassi Giustino , Wells Markus , Kaye Alan D.
Published: August 2021

Background

Chronic pain significantly worsens the quality of life. Unlike neuropathic, musculoskeletal, postoperative pain, and cancer pain, chronic primary pain cannot be explained by an underlying disease or condition, making its treatment arduous.

Objectives

This manuscript intends to provide a comprehensive review of the use of ketamine as a treatment option for specific chronic pain conditions.

Study Design

A review article.

Setting

A review of the literature.

Methods

A search was done on PubMed for relevant articles.

Results

A comprehensive review of the current understanding of chronic pain and the treatment of specific chronic pain conditions with ketamine.

Limitations

Literature is scarce regarding the use of ketamine for the treatment of chronic pain.

Conclusion

First-line treatment for many chronic pain conditions includes NSAIDs, antidepressants, anticonvulsants, and opioids. However, these treatment methods are unsuccessful in a subset of patients. Ketamine has been explored in randomized controlled trials (RCTs) as an alternative treatment option, and it has been demonstrated to improve pain symptoms, patient satisfaction, and quality of life. Conditions highlighted in this review include neuropathic pain, fibromyalgia, complex regional pain syndrome (CRPS), phantom limb pain (PLP), cancer pain, and post-thoracotomy pain syndrome. This review will discuss conditions, such as neuropathic pain, fibromyalgia, complex regional pain syndrome, and more and ketamine’s efficacy and its supplementary benefits in the chronic pain patient population. As the opioid crisis in the United States continues to persist, this review aims to understand better multimodal analgesia, which can improve how chronic pain is managed.
Service Quality (SERVQUAL) Dimensions on Customer Satisfaction: Empirical Evidence from Bank Study
Authors: Sugiarto Sigit , Octaviana Vivi
Published: August 2021

This study aims to determine how much influence service quality dimensions have on customers' satisfaction who use BRI services. The model used in this study is observation, interviews, questionnaires, and literature study using a Likert scale. The method of determining the sample used is 96 respondents. The analytical method used is the multi-linear regression method. The results of this study indicate that all variables are simultaneously serviced quality dimensions consisting of Tangible (X1), Reliability (X2), Responsiveness (X3), Assurance (X4), and Empathy (X5) together have a positive influence. Partially found services consisting of Tangible, Reliability, and Empathy have a positive and significant influence on customer satisfaction. At the same time, the quality of service which consists of Responsiveness and Assurance is not supported. Service quality is a critical aspect to satisfying the customers and retaining their loyalty, so they continue to buy from you in the future. Service quality is a comparison of customer expectation and the actual delivery of service. Service quality generally refers to a customer's comparison of service expectations related to a company's performance. A business with a high level of service quality is likely capable of meeting customer needs while also remaining economically competitive in their respective industry.
Protein and peptide research applied to Covid-19 and SARS-Cov-2
Authors: Hélène Gagnière  , Patrick Di Martino
Published: August 2021

The emergence of SARS-Cov-2 remains a challenge for the global scientific community. Many efforts have been made to rapidly develop vaccines against SARS-Cov-2. Currently available vaccines, based on the spike glycoprotein (S), are effective in generating neutralising antibodies to prevent severe acute forms of Covid-19. However, the emergence and spread of SARS-Cov-2 variants with mutations in the S protein raises questions about the need to adapt the vaccine strategy to the evolution of the virus. Proteome analysis of many SARS-Cov-2 clinical isolates suggests the development of vaccines based on peptides corresponding to epitopes located in the constant regions of viral proteins that could be effective despite the appearance of variants or the emergence of new strains of beta coronavirus. Other therapeutic innovations against Covid-19 could come from the development of peptides that inhibit structural and non-structural viral proteins. Beyond the therapeutic aspects, research on Covid-19-related proteins and peptides is also directed towards the development of diagnostic tools. The study of the glycosylation of viral proteins and the ACE-2 receptor is important for the development of therapies and diagnostics.
Mecanismos de la respuesta inmune adaptativa: respuesta específica y de protección a largo plazo
Authors: Ríos-Ríos William de Jesús , Aguilar-Cruz Jair
Published: August 2021

The human immune system has evolvedtoachieveahighlyefficient, specialized and specific immunity against particular molecular structures of each pathogenic microorganism and to develop mechanisms allowing to respond more quickly and efficiently to subsequent encounters with the same invading agent: the adaptive immune response. This paper describes the connection between the innate and adaptive immune response, as well as the cellular and humoral mechanisms of control and long-term protection of the adaptive immune response.
La respuesta inmune en acción contra la invasión de patógenos
Authors: Sosa-Luis Sorely Adelina , Pérez-Buendía Brenda Alín
Published: August 2021

The environment harbors a wide variety of microorganisms such as bacteria, fungi, viruses and parasites; along with toxic agents that could potentially damage the human body. Many microorganisms and their toxins have been responsible for big epidemics around the world. However, the human body is endowed with a protective shield called the immune system, which has evolved alongside microbes in a continuous battle to stop their invasion and the they bring. This paper describes the mechanisms integrated into the innate and adaptive immune responses to prevent, combat, eliminate and mount immune memory to different typesofpathogenicmicroorganisms.
Identificarea și caracterizarea tipurilor de soluri. Modelarea eroziunii solurilor, LS-factor. Studiu de caz Codrii de nord
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Angheluta Viorica
Published: August 2021

Northern Codrii represents a geographic entity in the Codrii Plateau and has a special morphological structure. Also, the wide range of pedological factors determined the formation of a very varied soil cover. Nowadays, a special attention in the soil survey is given to erosion, which is a serious problem both in Northern Codrii as well as on the whole territory of Republic of Moldova. In the current development of Geographical Information Systems, a quantitative assessment and modeling of the process of soil degradation is possible. Thus, LS-factor is a combined indicator of the L -factor, which defines the impact of slope length and S-factor, which measures the effect of the slope angle. Therefore, LS-factor describes the effect of topography on soil erosion, showing areas susceptible to erosion processes.
Studiul structurii peisajelor bazinului hidrografic Nârnova în baza imaginilor satelitare LANDSAT 8
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Stratan Liliana , Bejan Iurie ,   Institutul de Ecologie si Geografie, Republica Moldova
Published: August 2021

The efficient development of remote sensing and geographic information system technology provides more accurate technical support for the quantitative analysis of landscape pattern. In order to effectively reflect the current situation of the landscape pattern of the Nirnova river basin, it is better to understand the interaction between anthropic pressure and landscape elements, and to provide scientific basis and theoretical support for the regional landscape planning.
Considerațiuni privind folosirea polipedonului în aprecierea răspîdirii spațiale a solurilor
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Popov Leonid , Overcenco Aureliu ,   Institutul de Ecologie si Geografie, Republica Moldova, Curcubat Stela ,   Institutul de Ecologie si Geografie, Republica Moldova
Published: August 2021

The specificity of zonal pedogenesis factors and their influence on the horizon thickness in the soil profile contributes to the formation of specific characters for each horizon. A clear example can be observed in the interaction between pedogenesis and hydrology, where the illuvial and spontaneous processes move soil-clay minerals, oxides, soil carbon, carbonates and other compounds into the soil profile. Such reciprocal links allow the application of the statistical analysis to assess the variability of the horizons thickness and the prognosis of their spatial spread in relation to the factors that determine the formation of the horizon thickness.
Variabilitatea interanuală a indicelui termo-higrometric pe teritoriul Republicii Moldova
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Golovitcaia Xenia
Published: August 2021

The main purpose of this paper was to evaluate the climatic comfort and discomfort through one of the most representative bioclimatic indexes – thermo-hygrometric index (THI). The THI was calculated by using the monthly average of air temperature (°C) and relative air humidity (%). The data was obtained from 3 meteorological stations, for a period of 38 years (1980 – 2017). The recorded data at these three stations, represent each geographic region of the country (the north - Briceni, the centre - Chisinau and the south - Cahul) and were studied and presented in more details.
Analiza spaţio-temporară a duratei de strălucire a soarelui
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Cojocari Rodica
Published: August 2021

In temporal aspect, the duration of sunshine shows a general upward trend. In seasonal aspect, spring season demonstrates an increase of about +0.2 hours, summer - about 0.1 hours, in autumn there is a trend of decreasing, according to the trend line, and the oscillation is equal to zero hours. Also we observe the increase in the number of hours in the spatial aspect. For Briceni meteorological station, the annual amount of sunshine duration varies within the limits of 1544 hours (1980) and 2326 hours (2015). The oscillation limits at the Cahul meteorological station are 1880 hours (1976) and 2604 hours (1963). At the Chisinau meteorological station, there's general increasing trend for the number of hours during which the sunshine duration is maintained, and it exhibits oscillations within 1783 hours (1989) and 2498 hours (1963). In the spatial aspect for winter, this increase +1 hour in Cahul, +0.38 hours in Briceni, and + 0.4 hours / season in Chisinau. In spring, the highest value of +2.2 hours is observed at Briceni and the lowest in Chisinau +1.9 hours / season. At Cahul meteorological station the increase was +1.4 hours. The increase in summer is +1.7 hours in Briceni and Chisinau, and only +0.9 hours in Cahul. Autumn trend line is a downward trend with a -0.3 hours decrease registered at Briceni and Chisinau meteorological stations (minimum values), and -0.6 hours in Cahul, maximum value.
Характеристика сезонных изменений ветрового режима на территории Республики Молдова
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Mleavaia Galina
Published: August 2021

The statistical characteristics and identifying the patterns of spatial-temporal variability of the seasons wind mode in response to features of the complex relief conditions on the Republic of Moldova’s territory are presented in this article.
Evaluarea conținutului nutrienților în orizonturile solului nou-format de pe suprafața haldelor de steril în procesul de restabilire naturală a ecosistemului petrofit din cariera de calcar ,,Lafarge ciment”
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Bulimaga Constantin , Certan Corina ,   Institutul de Ecologie si Geografie, Republica Moldova, Burghelea Aureliu ,   Institutul de Ecologie si Geografie, Republica Moldova
Published: August 2021

It has been established that the content of heavy metals in tailings dumps of different ages does not exceed the alert threshold for any component. The content of K2O in the 0-20 cm layer is higher than in the 20-40 cm, which is explained by biogeochemical (phytocenotic) processes. It is demonstrated that the total nitrogen content on the surface of tailings dumps of different ages depends on their age. The highest nitrogen content is contained in the newly formed soil layer on the surface of the 25 year old waste heap in the 0-20 cm layer. This is explained by the fact that the largest number of plant species (63 units) that have produced the largest amount of organic substance (humus) from the mass of biodiversity are growing on this dump.
Educational activities in the management of the biosphere reserve area “Lower Prut” in Moldova
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Drumea Dumitru
Published: August 2021

Articolul elucidează rezultatele studiilor organizate in aria biosferei Prutul Inferior in perioadă 2014-2017. Aspectele educaționale in dezvoltarea ariei biosferei au fost discutate cu diferite autorități din regiune cât și cu representanții organizațiilor internaționale. Programele educaționale trebuie să se dezvolte in baza prevederilor Convențiior internaționale cu atragerea celor mai bune practici de management a ariilor biosferei și elaborării studiillor privind adaptarea la schimbările climatice, protecția biodiversității, dezvoltării sectoriale, atragerea investițiilor și dezvoltării sociale din regiune. Resultatele discuțiilor au fost propuse pentru includerea in agendele locale privind dezvoltarea sectorului educațional la toate nivelele.
Evaluări privind impactul secetei asupra speciilor de stejari (Quercus Robur, Q. Petraea, Q.Pubescens) în condiții de aridizare a climei
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Nedealcov Maria , Donica Ala ,   Institutul de Ecologie si Geografie, Republica Moldova, Grigoras Nicolae ,   Institutul de Ecologie si Geografie, Republica Moldova
Published: August 2021

The growth and survival of forests in the future, especially in the peripheral and transition areas of ecosystems, such as the Moldavian oak forests, depend directly on temperature changes and the amount of atmospheric precipitation. The purpose of this paper is to determine the potential impact of climate aridization on native species - oaks (Quercus robur, Q. petraea, Q.pubescens) in correlation with ecological niche for these species and identifying the vulnerability zones of forests versus the drought (reproduced by various values of the DeMartonne Index). It has been determined that mesophilic oak specie, during the vegetation period, in the central and southern part of the country, under more dry, more arid conditions of development, will feel changes in the sensitivity to water scarcity, changes in the compositional structure of the respective ecosystems and chorological displacements of the species (limiting the growth area of the Quercus robur, Q. petraea and advancing of Q.pubescens to the central part of country).
Mecanismul de reglementare economică a utilizării apelor în bh RĂUT (în limitele RD Centru)
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Bacal Petru , Railean Veronica ,   Institutul de Ecologie si Geografie, Republica Moldova, Burduja Daniela ,   Institutul de Ecologie si Geografie, Republica Moldova
Published: August 2021

The scope of this study is application of economic regulation of water use in the Raut river basin (in the limits of Central Development Region from Republic of Moldova. The main objectives of studies are: 1) the analysis of the costs and tariffs of the water supply and sanitation services; 3) the cost recovery analysis of water of water use of the public water supply and sanitation systems; 3) evaluation of financial performance of water supply companies; 4) financing of water sector the area of study; 5) elaboration of recommendations for reforming of economic mechanism for sustainable use of water resources.
Оценка влияния электромагнтного излучения промышленной частоты на природные и селитебные экосистемы
Authors:   Institutul de Ecologie si Geografie, Republica Moldova, Dragutan Igor , Kolomiet Irina ,   Institutul de Ecologie si Geografie, Republica Moldova, Scurpelo Anatolie ,   Institutul de Ecologie si Geografie, Republica Moldova
Published: August 2021

In the present work, the electromagnetic pollution caused by radiation of industrial frequency (50 Hz) was estimated in Orhei city. Five unfavorable loci were identified in residential areas of the city associated with noncompliance of the sanitary protection zone. Based the biotesting territory, it was found that the most sensitive morphophysiological traits of the test plant Polygonum aviculare L. are the length of the main stem and corolla coloring. It is observed that the greater transmission line voltage the longer of the main stem, and less the intensity of corolla color (from red to white).
Effect of water hyacinth compost on the morpho-physiological parameters of Soybean (Glycine max l.)
Authors: Ogbuehi HC  , Ibe PK
Published: August 2021

A pot experiment was conducted under rainfed condition to study the effect of water hyacinth compost on the morpho-physiological parameters of soybean (Glycine max L.) at the Teaching and Research Farm of Faculty of Agriculture and Veterinary Medicine, Imo State University, Owerri. The treatments were control (T1) 100g (T2), 150g (T3) and 200g (T4) of water hyacinth compost and replicated four times. The treatments were arranged in Complete Randomized Design (CRD). The parameters measured were plant height, number of leaves, leaf area (cm2), leaf area index, relative growth rate (RGR), Net assimilation rate (NAR), shoot dry weight(g), yield and yield components (Number of pods, pods weight, 100 seed weight). The results obtained indicated that T3 significantly produced highest plant height (57.6cm) compare to control. While it was observed that T4 (200g) significantly produced the highest number of leaves (233.25), leaf area (631.80cm2), shoot dry weight (15.445g), number of pods (129.75), pod weights (25.38g) seed weight (7.23g) and yield (0.72kg/ha) relative to control and other treatment levels. Root parameters were also significantly improved by the rates of water hyacinth application compared to control. It will be worthy to note that there was no nodulation perhaps that was why the yield was poor. The results showed that soybean growth can effectively be improved with incorporation of water hyacinth into soil.
Pengaruh Pendidikan Kesehatan Pijat Bayi terhadap Kualitas Tidur Bayi Usia 0-6 Bulan di BPM Dewi Suyanti Tahun 2020
Authors: Saddiyah Rangkuti
Published: August 2021

Pijat bayi adalah pemijatan yang dilakukan dengan usapan-usapan halus pada permukaan kulit bayi, dilakukan dengan menggunakan tangan yang bertujuan untuk menghasilkan efek terhadap syaraf, otot, sistem pernafasan serta sirkulasi darah dan limpha, tujuan penelitian untuk mengetahui apakah terdapat pengaruh pendidikan kesehatan pijat bayi terhadap kwalitas tidur bayi umur 0-6 bln di BPM Dewi Suyanti Tahun 2020. Penelitian ini menggunakan jenis penelitian kuantitatif,  dengan desain crosssectional, Desain penelitian ini menggunakan desain crosssectional, Populasi dalam penelitian adalah seluruh ibu yang memiliki bayi usia 0-6 bulan di klinik bersalin BPM Dewi Suyanti Tahun 2020 yaitu sebanyak 20 orang, sampel dalam penelitian ini total sampling seluruh ibu yang memiliki bayi usia 0-6 bulan sebanyak 20 bayi, dengan teknik penelitian menggunakan uji Chi Kuadrat. Hasil penelitian ini Ada pengaruh yang signifikan pendidikan kesehatan pijat bayi terhadap kualitas tidur pada bayi usia 0-6 bulan di di BPM Dewi Suyanti Tahun 2020, dengan nilai p value = 0,000 (p<0,05). Disarankan Bagi bidan di BPM Dewi Suyanti diharapkan dapat menyebarluaskan metode pemberian pijat bayi ini ke masyarakat, terutama bagi ibu-ibu yang baru melahirkan atau sedang melakukan imunisasi kepada bayinya sehingga ibu dapat melakukan teknik pijat bayi itu sendiri dan sedini mungkin kepada bayinya sebagai salah satu intervensi yang dapat membantu meningkatkan kualitas tidur bayi.
Faktor-Faktor yang Berhubungan dengan Terjadinya Penyakit Infeksi Saluran Pernafasan Akut (ISPA) di Puskesmas Pintupadang Kecamatan Batang Angkola Kabupaten Tapanuli Selatan Tahun 2020
Authors: Siregar Rahmat Rizki
Published: August 2021

ISPA (Infeksi Saluran Pernapasan Akut) adalah penyakit saluran pernapasan akut dengan perhatian khusus pada radang paru (pneumonia) dan bukan penyakit telinga dan tengorokan. Penyakit ISPA merupakan yang dapat menimbulkan kematian pada belita atau anak usia 5 tahun kebawah. Penelitian  ini bersipat deskriptif analitik, metode pengumpulan data dengan mengunakan alat yaitu questioner. Sampel dalam penelitian ini berjumlah 35 orang. Pengolahan data dilakukan dengan beberapa tahapan yaitu: analisis univariat untuk menggambarkan distribusi frekuensi dari masing-masing variabel, analisis bivariat untuk melihat hubungan Pengetahuan, Kebiasaan Merokok dan tingkat Ekonomi dengan penyakit saluran pernapasan akut (ISPA) menggunakan Chi-Square. Hasil uji statistik pengetahuan responden terhadap ISPA diperoleh P =0.97 ( p>0.05) artinya H0 diterima dan Ha ditolak menunjukkan tidak ada hubungan yang signifikan antara faktor pengetahuan terhadap infeksi saluran pernapasan akut (ISPA). Uji statistik Ekonomi responden diperoleh nilai P = 0.20 (P>0.05) artinya H0 diterima dan Ha ditolak ditolak menunjukkan tidak ada hubungan yang signifikan antara faktor ekonomi dengan infeksi saluran pernapasan akut (ISPA), uji statistik kebiasaan merokok responden diperoleh nilai P = 0.01 (P =< 0.05) artinya H0 ditolak dan Ha diterima hal ini menunjukkan terdapat hubungan yang signifikan antara faktor kebiasaan merokok  dengan  kejadian ISPA. Adapun saran program promotif dan preventif terhadap penyakit ISPA yang telah ada hendaknya dilaksanakan sefektif mungkin, agar angka kasus ISPA di Kecamatan Batang Angkola Kabupaten Tapanuli Selatan berkurang.
Hubungan Pengetahuan Ibu Hamil dengan Kecemasan dalam Menghadapi Hiperemesis Gravidarum Kehamilan Trimester I di RSUD Sultan Sulaiman Tahun 2020
Authors: Zuidah
Published: August 2021

Kecemasan pada kehamilan, selain terjadi perubahan fisiologi, psikologis juga memegang peranan yang tidak kalah penting dalam timbulnya mual muntah, Hiperemesis gravidarum yang merupakan komplikasi pada ibu hamil muda bila terjadi terus menerus dapat menyebabkan dehidrasi, tujuan penelitian untuk mengetahui apakah ada hubungan Pengetahuan Ibu Hamil Dengan Kecemasan Dalam Menghadapi Hiperemesis Gravidarum Kehamilan Trimester I di RSUD Sultan Sulaiman Tahun 2020. Penelitian ini menggunakan jenis penelitian kuantitatif,  dengan desain crosssectional, Desain penelitian ini menggunakan desain crosssectional, Populasi dalam penelitian adalah ibu hamil trimester  pertama  yang  melakukan  pemeriksaan  kehamilan  di RSUD Sultan Sulaiman Tahun 2020sebanyak 90 orang, sampel dengan mengunakan Acidental sampling yaitu dimana sampel yang didapat kan pada saat penelitia melakukan penelitian yaitu sebanyak 2 minggu, dengan teknik penelitian menggunakan uji Chi Kuadrat. Hasil penelitian Pengetahuan ibu hamil tentang hiperemesis gravidarum di RSUD Sultan Sulaiman mayoritas dalam kategori cukup sebanyak 16 orang (53,3%), Kecemasan ibu hamil dalam menghadapi hiperemesis gravidarum kehamilan trimester I di RSUD Sultan Sulaiman mayoritas berada pada kategori kecemasan sedang sebanyak 13 orang (43,3%). Kesimpulan Ada hubungan yang signifikan antara pengetahuan ibu hamil dengan kecemasan dalam menghadapi hiperemesis gravidarum kehamilan trimester I di RSUD Sultan Sulaiman Tahun 2020. Disarankan Bagi tempat penelitian, perlunya mengadakan penyuluhan kesehatan kehamilan agar tingkat kecemasan pada ibu hamil dalam menghadapi hyperemesis gravidarum pada kehamilan trimester I dapat diturunkan.