bluuebunny/crossref_metadata_2025 huggingface dataset:
POTENSI OVERKRIMINALISASI PADA PENGATURAN TINDAK PIDANA KOHABITASI DALAM KITAB UNDANG – UNDANG HUKUM PIDANA: PERSPEKTIF FAIR TRIAL
Authors: Prawira M. Rizki Yudha
Published: January 2025

Tindak pidana kohabitasi diatur dalam Pasal 412 KUHP yang melarang setiap individu untuk hidup bersama sebagaimana suami istri, kendatipun hubungan tersebut dilakukan di luar perkawinan. Adapun ancaman bagi setiap orang yang terbukti melanggar ketentuan ini adalah sanksi pidana penjara paling lama enam bulan atau pidana denda paling banyak kategori II (sepuluh juta rupiah). Pengaturan mengenai tindak pidana kohabitasi telah menimbulkan berbagai kekhawatiran, khususnya mengenai potensi kriminalisasi yang berlebihan atau dikenal dengan istilah overkriminalisasi. Menggunakan hukum pidana untuk mengatasi sebuah permasalahan haruslah menjadi upaya terakhir, sebagaimana diartikulasikan dalam prinsip ultima ratio. Douglas Husak telah memperingatkan bahaya overkriminalisasi, dimana negara diberikan wewenang yang terlalu luas untuk mengontrol individu di wilayah yurisdiksinya dengan menggunakan hukum pidana. Kriminalisasi suatu perbuatan harus mempertimbangkan pembatasan internal dan eksternal. Pembatasan internal berfokus pada tingkat kerusakan, kerugian dan niat jahat yang diakibatkan oleh sebuah tindakan, yang menjamin klasifikasinya sebagai tindak pidana. Selanjutnya, pembatasan eksternal juga menjadi faktor lainnya yaitu fokusnya pada kepentingan negara dan bagaimana kriminalisasi suatu tindakan dapat berkontribusi terhadap tujuan tersebut. Selain itu, terdapat kekhawatiran mengenai potensi terjadinya overkriminalisasi akibat dimasukkannya kohabitasi ke dalam KUHP, yang dapat bertentangan dengan prinsip-prinsip hak asasi manusia, khususnya hak atas peradilan yang adil. Di balik tujuan kriminalisasi tindakan kohabitasi dimana pendekatannya merujuk pada moral dan norma umum, diperlukan sebuah penelitian untuk mengkritisi pandangan tersebut sebagai bentuk sumbangan pemikiran baru khususnya kepada perkembangan hukum pidana di Indonesia.
ACCEPTANCE OF INTERACTIVE MULTIMEDIA LEARNING SOFTWARE i-TUTOR BAHASA MELAYU (i-TUTOR BM): INSIGHTS FROM RURAL SECONDARY SCHOOLS IN MALAYSIA
Authors: Robin Kenneth , Sharif Sabariah , Shaafi Nur Farha , Tan Choon Keong
Published: January 2025

The integration of technology in education has become increasingly vital, particularly in enhancing learning experiences in rural areas. Therefore, the aim of this study is to investigate the acceptance of an interactive multimedia learning software known as i-Tutor Bahasa Melayu (i-Tutor BM) among secondary school students in rural Malaysia. A questionnaire was adapted from Lewis (2019) to assess the software's usability (PU) and ease of use (PEU); distributed to 30 students who participated in the experimental study. The findings revealed high levels of both usability and ease of use, with average scores of 5.79 and 5.78 respectively. These results suggest that i-Tutor BM software is effective and user-friendly, indicating its potential to enhance learning outcomes in rural educational settings.
EXPLORING GAMIFICATION ELEMENTS IN EDUCATION: A BIBLIOMETRIC STUDY
Authors: Zakaria Nor Zaitul Shahira , Mahat Hanifah
Published: January 2025

This bibliometric study examines the integration of gamification elements within educational contexts, highlighting trends, influential research, and collaborative networks in the field. Gamification, increasingly recognized for its potential to enhance student engagement and motivation, has become a focal point in educational research. However, there remains a need for a comprehensive analysis to map its development, identify key contributors, and evaluate its impact. This study addresses these gaps by analyzing 1,637 documents from the Scopus database, focusing on publications related to gamification in education. Methodologically, Scopus Analyzer was used to identify publication trends, while VOSviewer software facilitated keyword mapping and co-authorship network analysis. The results reveal a steady increase in research activity, particularly since 2020, reflecting a growing acceptance of gamification as a viable educational tool. Key findings reveal that "gamification," "engagement," and "motivation" are frequently occurring keywords, indicating core themes within the field. The United States, Spain, and the United Kingdom emerged as the leading contributors in terms of publications and collaborations, highlighting significant international interest. Additionally, prominent authors have contributed substantially to advancing theoretical and practical knowledge on gamification's application in diverse educational settings. Despite this progress, gaps remain in standardized frameworks and longitudinal studies assessing gamification's long-term impact. In conclusion, the study underscores the extensive research interest in gamification within education, its established benefits, and the collaborative efforts across countries. Thus, future research should focus on addressing identified gaps by developing structured frameworks and conducting studies that evaluate the sustained effectiveness of gamified interventions across various educational contexts. This bibliometric analysis provides a foundation for educators, researchers, and policymakers to understand the evolving landscape of gamification in education.
Perancangan dan Implementasi Sistem Informasi Berbasis Website pada Toko Sembako Sayur Amanah
Authors: Rayhan Radhita , Fajri Ika Nur
Published: January 2025

In the midst of the rapid development of digital technology, various business sectors, including the trade sector, have begun to adopt digital-based information systems to improve operational efficiency and effectiveness. Toko Sembako Sayur Amanah currently still relies on a manual system for recording transactions, managing stock items, and financial reporting using a cash book. This manual system causes the sales process to be inefficient, time-consuming, and prone to errors such as misrecording or data loss. In addition, the manual system is unable to meet the needs of customers who have limited time and makes it difficult to manage transactions and stock items effectively. To overcome these problems, this research aims to design and implement a website-based information system using the Waterfall method, which includes requirements analysis, system design, implementation, and system testing. Testing is carried out with a Black-box Testing approach to ensure the suitability of system functionality with predetermined needs. The test results show that the developed system has succeeded in increasing the efficiency of managing categories and goods by the admin and making it easier for customers to place orders and make payments online. This research is expected to be a reference for the development of similar systems in other grocery stores with the potential to increase competitiveness in an increasingly competitive market. As a follow-up, this research opens up opportunities for further development, such as integration with mobile applications or more sophisticated inventory management systems.
The Effect of Social Support for Career Adaptability on Final-year Students at State University of Manado
Authors: Veronika Tiara
Published: January 2025

This research is based on the assumption that career adaptability is very important for final year students to be able to cope with the challenges of the transition from university to work. The aim of this study is to investigate the effect of social support on career adaptability. Quantitative regression analysis tests were used as the research method. The population selected were final year students at the State University of Manado using a simple random sampling technique and a total sample of 51 students. The adaptability career scale (α = 0,90) and the social support scale (α = 0,91) were the instruments used in this study. Based on the results of the regression analysis test, there is a negative effect of social support on adaptability to work. The researchers suggest that the conditions caused by social support that are received too often will, in fact, make it more difficult for students to make decisions about their careers. Social support offers knowledge and strategies for experiencing career change. This situation is not compatible with the careers of the new economy.
The Relationship Between Self Esteem and Impulsive Buying of Fashion Product Through Online Shopping Among Early Adult Women
Authors: Sinaga Bestin Julyan , Rahayu Maria Nugraheni Mardi
Published: January 2025

Online shopping is an activity that is often found today. This makes it easier for people to shop because it can be done at home. The ease of shopping online makes people often do it without considering the uses or benefits of the products purchased; this can refer to impulsive buying. This study aims to determine the relationship between self-esteem and impulsive buying of fashion products through online shopping among early adult women in Banjarnegara. The method used in this study is quantitative with a correlational design. Participants in this study were 121 early adult women in Banjarnegara who shopped online and made random purchases. The technique used is incidental sampling. The research measurement used the self-esteem scale and the impulse buying scale, and questionnaires were distributed online. Data analysis was performed using parametric statistical analysis, namely Pearson correlation analysis. The results showed that there was no relationship between self-esteem and impulsive buying of fashion products through online shopping among early adult women, with a value of r = -0,12 (p = 0,09). This means that self-esteem is not a major factor for early adult women in Banjarnegara in making impulsive purchases.
Achievement motivation and work procrastination of lecturers
Authors: Komalasari Shanty
Published: January 2025

This study aims to determine the achievement motives and work procrastination of civil servant lecturers at UIN Antasari Banjarmasin with 147 subjects. The sampling technique used purposive sampling. The data collection instrument used a scale of achievement motive and work procrastination Likert model and analysis using the Correlation Product Moment with the help of SPSS 21 for Windows. The study shows that the achievement motive level and work procrastination are moderate. The correlation test shows a significant negative relationship between the two variables (p < 0.05), with a value of Pearson Correlation -0.631, which means a strong relationship exists. So, the higher the achievement motive, the lower the work procrastination and vice versa. Individuals with high achievement motives will not be overwhelmed by doubts when completing tasks and will make serious efforts to complete the work.
Protocolos de rehabilitación para pacientes con artroplastia total de cadera, Corrientes-Argentina y Araranguá-Brasil en los años 2022 al 2024
Authors: Agustina Elizabeth Honfi  , Lorena Ruth Acosta  , Karina Irupé Lescano
Published: January 2025

Hip arthroplasty is a widely used type of surgery, recognized as well as pre and post-surgical kinesiological rehabilitation to restore functionality and mobility to the person, reduce pain and allow the individual to return to daily life and work activities in an early manner. Objective: To know the protocols used in Argentina and Brazil for the rehabilitation of patients with total hip arthroplasty. Methodology: A retrospective cross-sectional descriptive research was carried out on clinical histories of 15 patients who attended the University Service of Kinesiology UNNE Corrientes (Arg.) and 15 patients attended at the Regional Hospital of Araranguá, Santa Catarina (Brazil). An anonymous registration form with data on age, gender, occupation and type of rehabilitation treatment received after hip arthroplasty was used as an instrument for data collection. Results: Most of the patients were women (63.3%), 50% of the total were between 60 and 69 years of age, the care in both registries consisted of a physiotherapeutic and kinesitherapy module, that is, the patients had a moment where they were treated with physical agents and then they were taken to the gym. A total of 33.3% were rehabilitated only with kinesitherapy techniques, and 16.7% only with physical agents (physiotherapy). Conclusion: Rehabilitation protocols are adjusted and combined to the patient’s own needs.
Salud digital en adolescentes de primer grado de secundarias públicas y privadas del estado de San Luis Potosí en el año 2023
Authors: Omar Medina de la Cruz  , Francisca Angélica Hernández Torres  , Lucía Gabriela Rosales Ortuño  , Tania Jasso-Reyes  , Pedro Pablo Govea González  , Elisa Gosh de la Garza  , Verónica Gallegos García
Published: January 2025

Objective: To identify digital health habits in first-grade adolescents from public and private high schools in the state of San Luis Potosí. Methodology: A quantitative, descriptive, cross-sectional research was conducted. A total of 21,044 first-year adolescents from 245 public and private high schools in the 58 municipalities of San Luis Potosí participated. The 'Answer with the Net' survey, validated and reliable with 65 items (16 on digital health), was applied in May 2023. Statistical analysis was performed using STATA version 16 to estimate averages and proportions. Results: Among participants, 50.4% were women, and 49.6% were men. The predominant age was 13 years (89.53%). The most used social network was Facebook (56.56%). Only 11.14% engage in sports during free time, 23.57% feel irritated when a video game malfunctions, 25.65% accept friend requests from unknown persons, and 76.52% shared personal data on social networks. Conclusion: This is one of the first studies revealing behavioral patterns regarding the state of digital health in adolescents from San Luis Potosí. Findings highlight the need for educational strategies addressing the conscious and safe use of social networks.
La evaluación en los procesos didácticos educativos y su impacto en la enseñanza del inglés
Authors: Ángel Carmelo Prince Torres
Published: January 2025

El sistema educativo está conformado por diversos procesos y entre ellos, se encuentra la evaluación como una forma de visualizar los aspectos para potenciar toda la práctica, lo cual incide en las ramas del conocimiento incluido el aprendizaje de lenguas. En este artículo el propósito general fue comprender la importancia de la evaluación de los aprendizajes en el contexto didáctico, así como su interrelación con la enseñanza del inglés. La metodología empleada fue la implementación de un diseño documental bajo enfoque cualitativo con apoyo en la hermenéutica y la reflexividad, aplicando técnicas para el manejo de fuentes bibliográficas como la lectura o el resumen. Se determinó como resultado que la evaluación genera cambios educacionales, debe ser diversificada en la enseñanza del inglés y el docente es un agente fundamental en su configuración. Se concluyó que la evaluación es multidimensional y por ello, debe contar con personal capacitado para aplicarla especialmente dentro del aprendizaje del inglés a modo que pueda provocar el desarrollo de las personas involucradas e incluso de la sociedad.
Unilateral or Bilateral Percutaneous Endoscopic Debridement and Drainage for Thoracolumbar Infections: A Systemic Review and Meta-analysis
Authors: Ye Zhou
Published: January 2025

BACKGROUND: Unilateral percutaneous endoscopic debridement and drainage (UPEDD) and bilateral PEDD (BPEDD) are commonly implemented, and have consistently yielded favorable clinical outcomes. Nevertheless, there is a scarcity of literature contrasting the advantages and disadvantages between these 2 procedures.

OBJECTIVE: The goal of this research was to conduct a meta-analysis to compare the clinical effects of UPEDD and BPEDD.

STUDY DESIGN: A systematic review and meta-analysis.

METHODS: A systematic review of studies reporting outcomes following UPEDD and/or BPEDD procedures was performed. The extracted data were used for meta-analysis. Pooled event rates for positive bacteria culture, pain control satisfaction, reoperation, and complications were estimated. The pooled operation time and blood loss were also calculated.

RESULTS: Among 764 retrieved articles, 28 studies with 661 patients met the inclusion criteria and were used for our meta-analysis. A total of 21 studies (462 patients) investigated UPEDD outcomes and 7 studies (199 patients) investigated BPEDD outcomes. For the UPEDD group, the pooled event rates for positive bacteria culture, pain control satisfaction, reoperation, and complications were 72%, 91%, 9% and 4%, respectively; the pooled operation time and blood loss were 89.90 minutes and 59.77 mL. For the BPEDD group, these were 79%, 92%, 4%, 8%, 93.23 minutes and 64.93 mL, respectively.

LIMITATIONS: First, all included studies were retrospective series, limiting our study design to a single-arm meta-analysis. Second, there was a limited amount of studies that were determined to be fitting, particularly on BPEDD; the sample size was also small. Third, the clinical effects of UPEDD and BPEDD needed to be compared in greater detail, such as the time it took for inflammatory markers to return to normal, the incidence of local kyphosis, and whether the duration of antibiotic use could be shortened after adequate debridement with BPEDD. Lastly, further studies are necessary to compare the clinical outcome of PEDD and percutaneous endoscopic interbody debridement and fusion.

CONCLUSIONS: Both UPEDD and BPEDD can provide a relatively reliable causative-pathogen identification and satisfactory clinical outcome. The 2 techniques are not significantly different in terms of positive bacteria culture rate, pain control satisfaction rate, complication rate, and reoperation rate.

KEY WORDS: Percutaneous endoscopic debridement and drainage, unilateral, bilateral, spinal infection
Effectiveness of Radiofrequency Ablation for Treatment of Glossopharyngeal Neuralgia: A Systematic Review of the Current Literature
Authors: Zhitny Vladislav
Published: January 2025

BACKGROUND: Glossopharyngeal neuralgia (GPN) is a rare cause of facial pain that has an incidence of less than one per 100,000 people. The excruciating stabbing pain experienced by patients with GPN can be debilitating, leading to difficulties in activities of daily living, such as eating and speaking. As a result, there has been a recent increase in research on the effectiveness of radiofrequency ablation (RFA) for treating GPN.

OBJECTIVE: The objective of our study was to evaluate the effectiveness of (RFA for treating GPN while examining its impact on patients’ quality of life and assesses for any associated side effects.

STUDY DESIGN: The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) model was employed to identify articles from 2 comprehensive medical databases. The patient outcomes and numbers from each article were aggregated and calculated in order to determine the percent efficacy of RFA for treating pain associated with GPN.

METHODS: In this systematic review, the PRISMA review model was utilized to search through the PubMed and EMBASE databases. A comprehensive literature review was conducted. Of the initial 1,580 articles identified, 18 articles were included for analysis. Studies included in this systematic review encompassed idiopathic cases and secondary causes, such as an elongated styloid process, oropharyngeal cancers, and postsurgical/traumatic pain.

RESULTS: Of the 288 patients treated with RFA, 231 experienced relief or complete resolution of pain, yielding an efficacy rate of 80.2%. Most of the patients experienced immediate pain relief after RFA; however, some patients reported numbness, dysphagia, and changes in taste. Our study examines the potential use of RFA as a minimally invasive and effective treatment for GPN.

LIMITATIONS: Limitations of our study include the absence of comparisons between different types, modes, and settings of RFA procedures. The use of only 2 medical databases is another limitation. Finally, our systematic review does not include any randomized controlled trials.

CONCLUSION: RFA is efficacious in treating GPN with over 80% of patients experiencing postprocedure pain relief. However, further research in the form of clinical and controlled trials is needed to contribute to a better understanding of RFA’s long-term outcomes for patients with GPN.

KEY WORDS: Glossopharyngeal neuralgia, facial pain, radiofrequency ablation, facial pain, chronic pain management, pain measurement
Pulsed Radiofrequency Therapy at Different Voltages on Dorsal Root Ganglia Using Multifunctional Catheter to Treat Low Back Pain: A Comparative Retrospective Study
Authors: Nosella Paola
Published: January 2025

BACKGROUND: Applying pulsed radiofrequency (PRF) to the dorsal root ganglion (DRG) is an electrical neuromodulation technique, a valid complementary therapeutic treatment for failed back surgery syndrome (FBBS). Peridurolysis, when applied to vertebral canal adhesions, can be performed with dedicated catheters, providing patients with the benefits of mechanical, electrical, and pharmacological techniques.

OBJECTIVES: The aim of this study was to evaluate PRF’s effects on the DRG as part of FBSS treatment at different follow-up times, comparing 2 groups of patients exposed to distinct levels of voltage (100 V vs. 45 V) from a PRF generator.

STUDY DESIGN: A retrospective observational study was performed.

SETTING: The study was conducted on a sample of patients from an Italian hospital.

METHODS: PRF’s effects on the DRG as part of FBSS treatment were evaluated through the Numeric Rating Scale (NRS) and the monitoring of 155 patients’ opioid consumption at 3, 6, and 9 months. A Cosman® G4 model PRF generator was used. During follow-up periods, the Friedman test was applied to detect differences in outcomes between the 2 groups of patients, who were treated with different levels of voltage.

RESULTS: The most frequent diagnosis (61.29%) was FBBS in patients at a mean age of 64 (± 11.8) years old. All patients were treated with PRF on the dorsal ganglion, with the addition of a drug mixture. Most were treated with 100 V (62%). A statistically significant decrease (P < 0.001) in the NRS score emerged both as a whole and in the 2 distinct groups. Moreover, the group of 100 V patients showed a significant (P = 0.0360) reduction in the use of opioids.

LIMITATIONS: This observational retrospective study was based on a convenience sampling that involved a limited number of patients.

CONCLUSIONS: E-field technology is the only way to generate a constant 38°/42° PRF and 100 V level throughout surgical interventions (respecting the exposure times “set” by the operator). The patient will not feel any pain or electric current because the generated milliamperes will be greatly reduced.

KEY WORDS: Pulsed radiofrequency, dorsal root ganglion, different voltage, high voltage, Cosman G4 PRF generator, e-field, failed back surgery syndrome, neuromodulation, peridurolysis
Unintentional Injection Into the Retrodural Space of Okada During Transforaminal Epidural Steroid Injection
Authors: Choi Yun Suk
Published: January 2025

BACKGROUND: Transforaminal epidural steroid injection (TFESI) is commonly used for radicular pain, but can lead to an unintentional injection into the retrodural Space of Okada (RSO), an extradural space located dorsal to the ligamentum flavum, instead of the epidural space.

OBJECTIVES: To determine the prevalence and describe the fluoroscopic imaging features of an unintentional injection into the RSO during a TFESI and to review the history of injections into the RSO.

STUDY DESIGN: Observational study and original research.

SETTING: This work was conducted at Jeju National University School of Medicine, Jeju, Republic of Korea.

METHODS: A total of 5,429 lumbar TFESIs performed from the September 1, 2018 through October 31, 2021 were analyzed for unintentional RSO injections using fluoroscopic-guided contrast medium patterns.

RESULTS: The rate of unintentional injection into the RSO was 0.20% (11 incidents). Contrast medium patterns in the RSO had a sigmoid or ovoid shape confined to the affected facet joint, or a butterfly-shaped pattern extending into the contralateral facet joint, but rarely extending beyond the upper or lower level.

LIMITATION: The rarity of unintentional injection into the RSO prevented a randomized controlled study design.

CONCLUSIONS: Careful fluoroscopic examination of contrast medium patterns during lumbar TFESI is crucial to identify needle placement in the RSO. If detected, the procedure can be corrected by slightly advancing the needle into the foramen.

KEY WORDS: Contrast pattern, epidural space, facet joint, fluoroscopy, Space of Okada, transforaminal epidural steroid injection
PERLINDUNGAN DAN JAMINAN KEPASTIAN HUKUM TERHADAPBUKTI SURAT KEPEMILIKAN TANAH NON SERTIFIKAT (STUDI KASUS KEPEMILIKAN TANAH DI KABUPATEN SORONG)
Authors: Fikri Rizal Haedar , Sutikno Aldilla Yulia Wiellys , Azis Mariya
Published: January 2025

Kepastian hukum peralihan hak atas tanah diseluruh wilayah Indonesia harus didaftarkan ke kantor pertanahan setempat. Kebijakan pelaksanaan pendaftaran tanah yang dilakukan di wilayah Kabupaten Sorong Provinsi Papua Barat tidak dapat terlepas dari eksistensi, dan peran Lembaga Masyarakat Adat (LMA) Malamoi yang merupakan perwakilan dari masyarakat adat. Penelitian ini dilakukan dengan menggunakan pendekatan penelitian yuridis empiris atau penelitian hukum mengenai pemberlakuan serta implementasi ketentuan hukum normatif secara in action pada setiap peristiwa hukum yang terjadi dalam masyarakat. Sebagai salah satu bentuk syarat pelengkap dalam pendaftaran tanah. Setelah diterbitkannya sertifkat maka pemegang sertifikat wajib mengelola dan mandayagunakan tanah tersebut agar tanah yang dihakinya terpelihara dan meminimalisir adanya klaim dari pihak lain atau tetangga batas, karena sistem hukum tanah di Papua sini khususnya dikabupaten sorong mensyaratkan adanya kebenaran materil dan formil dalam kepemilikan tanah, bukti materilnya adalah penguasaan fisik, sedangkan bukti formilnya adalah sertifikat tanah, sehingga terjadi kepastian hukum.
Penyelesaian Tindak Pidana Perzinaan Secara Hukum Positif, Hukum Islam Dan Hukum Adat Kedang Lembata
Authors: Rahayu Denada Galuh Thampyana , Rumlus Muhamad Hasan
Published: January 2025

Dalam pandangan Islam, zina merupakan perbuatan kriminal (jarimah) yang dikatagorikan hukuman hudud. Yakni sebuah jenis hukuman atas perbuatan maksiat yang menjadi hak Allah SWT, sehingga tidak ada seorang pun yang berhak memaafkan kemaksiatan tersebut, baik oleh penguasa atau pihak berkaitan dengannya. Hukum pidana positif yang diatur dalam Kitab Undang-undang Hukum Pidana (KUHP) memang memberikan ancaman pidana terhadap kejahatan yang secara selektif ditetapkan sebagai perbuatan pidana sesuai dengan perkembangan politik hukum pidana. perzinaan menurut hukum positif dan menurut Hukum Islam, tampak adanya perbedaan yang cukup jelas, yaitu di dalam hukum positif, tindak pidana perzinaan hanya untuk orang yang sudah ada ikatan perkawinan baik salah satu atau pun kedua- duanya dan hanya mendapatkan hukuman yang ringan serta hanya dapat diancam hukuman penjara kalau ada yang melaporkan perbuatan zina tersebut. Hukum adat dalam menyelesaikan tindak pidana zina adalah dengan membayar denda atau sesuai hukum atau aturan yang berlaku di suatu daerah tertentu. Dalam artikel ini penyelesaian tindak pidana zina yang terjadi di kabupaten Lembata (NTT) sesuai Hukum adat kedang.
Kata kunci: Zina, Hukum, Islam, NTT, Adat.
Analysis of the association of influenza clinical course with single nucleotide polymorphisms in genes affecting the interferon-λ3 production
Authors: Nikolaeva Lyudmila I. , Stuchinskaya Maya D. , Telepenina Kristina P. , Shevchenko Nadezhda G. , Kuprianov Victor V. , Krasnoslobodtsev Kirill G. , Mukasheva Evgenya A. , Trushakova Svetlana V. , Khlopova Irina N. , Kruzhkova Irina S. , Kisteneva Lidya B. , Kolobukhina Lyudmila V. , Burtseva Elena I.
Published: January 2025

Introduction. Predisposition to different courses of the infectious process is largely associated with the polymorphisms in human genome, especially in genes encoding proteins of the immune system. In the early stages of influenza infection such components of innate immunity as interferons I (α/β) and III (λ) type play a significant role in limiting virus replication.
The aim of the work was to investigate associations of single nucleotide polymorphism in IFNL3 (rs8099917 T/G) and IFNL4 (rs12979860 C/T) genes with different course of influenza, and identify genetic markers of influenza complicated by community-acquired pneumonia. The genes noted above affect the production of interferon-λ3, which is involved in restriction of the viral replication.
Materials and methods. Samples from 456 patients with mild (n = 150), moderate (n = 173), and severe (n = 133) influenza were studied. The viral RNA was detected by reverse transcription and polymerase chain reaction (RT-PCR). Polymorphisms in IFNL3 (rs8099917 T/G) and IFNL4 (rs12979860 C/T) genes was detected by PCR. Statistical analysis was performed using SNPStats software.
Results. Patients with the C/T or T/T genotype of IFNL4 gene (rs12979860 C/T) were more likely to have pneumonia than those with the C/C genotype (OR 2.47 (1.31–4.63); p = 0.0044; q = 0.0059). The presence of one T allele increased the risk of developing pneumonia (OR 2.02 (1.05–4.02); p = 0.006; q = 0.008). In the presence of the T/T genotype, the risk increased more than twofold: OR 2.14 (1.31–3.48). Analysis of the SNP of IFNL3 gene (rs8099917 T/G) revealed a weak association of the G allele with pneumonia (OR 1.86 (1.04–3.31); p = 0.03; q = 0.045).
Conclusion. Genetic markers of increased risk of community-acquired pneumonia in influenza include the presence of the T allele in IFNL4 gene (rs12979860 C/T) and, to a lesser extent, the G allele in IFNL3 gene (rs8099917 T/G). Patients carrying these alleles have an increased risk of developing pneumonia, especially in old age.
Pre-clinical safety studies of intranasal virus-like particles based vaccine for prevention of COVID-19
Authors: Chernoryzh Yana Y. , Kondratieva Valeria M. , Malkova Аnastasia P. , Savochkina Tatyana E. , Eliseeva Olesya V. , Latyshev Oleg E. , Yakunin Dmitriy Y. , Zaykova Olga N. , Sludnyakova Ekaterina S. , Grebennikova Tatyana V.
Published: January 2025

Introduction. The large-scale and prolonged pandemic of the novel coronavirus disease (COVID-19) has demonstrated the need for effective vaccination. Along with immunogenicity, safety is a critical issue for vaccines, as public trust can contribute to the success or failure of immunization programs. In preclinical studies, we assessed the safety of an intranasal Virus-like particle (VLP)-based vaccine in mice and rats.
The aim of the study is to conduct preclinical acute and subchronic toxicity studies assessing local tolerability of an intranasal VLP vaccine against COVID-19 in accordance with good laboratory practice.
Materials and methods. Study was performed on adult outbreed mice (30 males, 30 females) and rats (45 males, 45 females). Physiological, morphometric and histological parameters, as well as general and biochemical blood tests and urine analysis were assessed.
Results. No deaths or intoxication were recorded in the acute toxicity study on mice, all parameters were within the physiological norm. In the subchronic toxicity study on rats, no changes in the general condition, behavior, or death of animals were noted. The structure of internal organs, blood and urine tests, hemostasis did not differ significantly between the groups. No local irritant effect was detected at the injection site during visual assessment, cytological and histological analysis.
Conclusion. The VLP vaccine is safe, as evidenced by the results of preclinical studies, does not negatively affect the function of various organs, the level of cellular and biochemical biomarkers in the blood and urine of mice and rats. Visual assessment, cytology and histology of the vaccine injection site did not reveal any local irritant effect.
Therapeutic Management of Giant Ameloblastomas
Authors: Mourabit Fadwa , Boukhani Meriem El , Aziz Zakaria , Mansouri Nadia
Published: January 2025

Ameloblastoma is a benign tumor but rapidly extensive and prone to recurrence. It affects young people and especially males. Radiological examination is essential as well as biopsy to confirm the diagnosis, the treatment is surgical which consists of an exeresis with safety margins. The reconstruction constitutes a real challenge in the face of giant ameloblastomas.
A Study to Assess the Knowledge Regarding Prevention of Micro and Macrovascular Complications of Type II Diabetes Mellitus among the Patients Attending the Diabetic Club of BVVS HSK Hospital and Research Center, Bagalkot with a View to Prepare an Information Guide Sheet
Authors: Habalakatti Kususma F. , D Prafulla Kumar, , Natekar Deelip S.
Published: January 2025

Background of the Study: Type II Diabetes is an impairment in the way the body regulates and uses sugar (glucose) as a fuel. This long-term (chronic) condition results in too much sugar circulating in the bloodstream. Eventually, high blood sugar levels can lead to disorders of the circulatory, nervous and immune systems. Aim: The aim of the study was a study to assess the knowledge regarding prevention of micro and macrovascular complications of Type II Diabetes mellitus among the patients attending the diabetic club of BVVS HSK Hospital and research center, Bagalkot with a view to prepare an information guide sheet. Methodology: This was non experimental descriptive research design. The population involved in this study was the Type II Diabetes mellitus patients who are attending the diabetic club of BVVS HSK Hospital and Research Center, Navanagar, Bagalkot and 80 subjects were selected using convenient sampling technique for the study. Data was collected from internet, review of literature, journals, articles and discussing with guide and subject experts. Data were analyzed by using descriptive and inferential statistics. Results: The research hypothesis H2 “There will be significant association between the level of knowledge and selected socio-demographic variables” as stated by the investigator earlier was rejected in the case of demographic variable religion and accepted in the case of other socio-demographic variables such as age, gender, educational status, type of family, residential background, diet and habit. Conclusion: The knowledge scores of the study shows that maximum of type II diabetes mellitus patients had in-adequate knowledge level, moderate type II diabetes mellitus had satisfactory knowledge and minimum type II diabetes mellitus patients were had adequate knowledge out of the selected sample of Type II Diabetes Mellitus patients. There was a significant association between the level of knowledge and almost all the selected ....
The Imperative of Exploratory Data Analysis in Machine Learning
Authors: Dhummad Sukhdevsinh
Published: January 2025

Exploratory Data Analysis (EDA) is a systematic approach to explore data through visualizations, statistical summaries, and identifying underlying patterns. It helps uncover data insights such as outliers, relationships within the dataset, and trends. EDA reveals information that influences the design and implementation of machine learning models. EDA insights provide a strong foundation for pipeline development and model deployment. Exploratory data analysis is generally the first step in any data analytics workflow. It allows analysts to detect dependencies and connections between factors. The results form a foundation for advanced activities like statistical analysis and help reduce potential failures by validating initial dataset assumptions.
Numerical Simulations of Shock Wave Turbulent Boundary Layer Interaction over a Flat Plate at Mach 6
Authors: Mehta R. C.
Published: January 2025

Unsteady numerical simulation is carried out for shock wave turbulent boundary layer interaction (SWTBLI) at wedge shock angle θw = 10o over a flat plate at freestream Mach 6 for freestream Reynolds number varying from 17.2 × 106, 37.3 × 106 and 72.8 × 106/m and wall to stagnation temperature ratio Tw/T = 0.56. A preliminary investigation is presented to analyse the fluid-surface interaction and to determine the sound pressure level. Spectral analysis is carried out using Fast Fourier Transform. The maximum shock wave frequency is about 645 Hz. The maximum sound pressure level of 110 dB is found near the separation points. The pressure and the heat flux fluctuations are found to be strongly, especially near the separation and reattachment points.
Mucoepidermoid Carcinoma of the Tracheobronchial Tree: A Rare and Challenging Case in Interventional Pulmonology
Authors: Rayhan Mohammad Zannatul , Sarker Md Zakir Hossain , Khair M Murtaza , Alam Most Mehenaz , Sadi Md Rokib
Published: January 2025

Mucoepidermoid carcinoma of the tracheobronchial tree is extremely rare and presented as similar to other respiratory diseases. In our case, a 19-year-old lady presented with cough with mucoid sputum production, wheezing, and breathlessness for 6 months. She also complained of low-grade fever for 1 month. Initially treated with antibiotics and bronchodilators but treatment was not satisfactory. Then after further workup, it showed tracheal growth covering 80% of the lumen. An urgent bronchoscopic debulking was done by Snare and Argon plasma coagulation. A complete resection was done and no subsequent surgical excision was required. Histopathology showed that it was mucoepidermoid carcinoma. After 1 year of follow up showed an excellent prognosis and no further growth was seen. Interventional pulmonology can play a big role shortly. A good expertise in interventional pulmonology is a prerequisite.
Analisis Risiko Kegagalan Proses Produksi Bakpia Menggunakan Metode FMEA Di Rumah Produksi Bakpia AS Sidoarjo
Authors: Abdussalam Isa , Dwi Sukma Donoriyanto Dwi Sukma Donoriyanto
Published: January 2025

The bakpia production process, which consists of various stages, starting from selecting raw materials, mixing dough, baking, to packaging, has the potential risk of failure at each stage. These risks, if not managed properly, can reduce product quality, reduce customer satisfaction, and even cause business losses. The method used in the study was FMEA and proposed improvements with 5W + 1H. Based on the FMEA analysis, the risk with the highest Risk Priority Number (RPN) value was incorrect temperature settings (240). The 5W + 1H analysis revealed the main causes of this risk, namely uncalibrated ovens, uneven heat distribution, and lack of temperature monitoring during baking, which was carried out in the production area by workers. To reduce the risk, periodic oven calibration, use of temperature monitoring devices, worker training, and standardization of operational procedures are recommended. This study proves that the combination of FMEA and 5W + 1H methods is effective in helping MSMEs such as Bakpia AS in identifying, analyzing, and mitigating risks in order to improve product quality and operational efficiency
Sarcoma cardíaco indiferenciado/no clasificado de alto grado
Authors: Herrera-Martínez Daniel Alejandro , Mestre-Sequeda Epitafio Rafael , Saad-Cure Carlos Enrique , Pérez-García Jesús Antonio
Published: January 2025

La rara presentación de las neoplasias cardiacas primarias representa importantes desafíos clínicos, diagnósticos y terapéuticos. Aproximadamente el 75% de los tumores primarios son benignos y un 25% son malignos. Presentamos el caso de una paciente de 79 años con clínica de dolor torácico y disnea, en quien se evidencia masa cardiaca por ecocardiografía, con estudio histopatológico de sarcoma pleomórfico indiferenciado de alto grado. Este caso resalta la importancia de la poca frecuencia y su manifestación asociada con el compromiso de la válvula mitral.
Enfermedad de Still del Adulto severo
Authors: Cumpa-Quiroz Ebert Robert , Camaiora-Calderon Allegra , Salinas-Laos Arantza , Moya-Ayon Maria Jimena , Flores-Sanz Flavio Nicolás
Published: January 2025

Mujer de 67 años con historia de seis meses de fiebre, asociada a odinofagia, rash y artralgias. A través de resultados laboratoriales, imagenológicos y tras excluir enfermedades endocrinológicas, infecciosas y hematológicas, se confirmó estar frente a un cuadro de Enfermedad de Still del Adulto, apoyado en niveles significativamente elevados de ferritina y evolucionando con serositis, hepatoesplenomegalia y compromiso hematológico severo de tipo activación macrofágica. Se obtuvo respuesta favorablemente a terapia inmunosupresora con resolución de síntomas y reversión del compromiso sistémico.
Ruptured Pseudoaneurysm in a Renal Angiomyolipoma: Case Report and Literature Review
Authors: Mostafa Mostafa M. , Kamel Mostafa , Zarzour Mohamed , Mahdy Ayman
Published: January 2025

Pseudoaneurysm formation in angiomyolipoma (AML) is a rare complication of the disease that can be fatal in the case of improper management. Options for diagnosis and treatment depend on how quickly you proceed in management. We present a case of a 46-year-old female with a ruptured pseudoaneurysm in the right renal AML. The rapid diagnosis with color Doppler ultrasound and contrast-enhanced computed tomography, together with the urgent management with selective angioembolization, were very effective. However, the development of an infected perinephric hematoma made subsequent open drainage and concomitant partial nephrectomy a must. We are also presenting a literature review on the condition using three databases and a random search to reflect on the incidence and associations of that condition with different management and experience. Pseudoaneurysm formation in AML occurs more frequently in young females and is mostly associated with the tuberous sclerosis complex. The rupture of the pseudoaneurysm is a serious complication and can occur spontaneously or with minor trauma. The risk of rupture of pseudoaneurysm is unpredictable; however, a large pseudoaneurysm with a large tumor in a female patient should represent an alarming sign of the need for more intensive follow-up. The gold standard in treatment is selective angioembolization after stabilization of the patient’s general condition.
Outcomes of segmentectomy versus lobectomy in adults with non-cystic fibrosis bronchiectasis
Authors: de Sá Moraes Neto1 José , Alves Chirichela1 Isabele , Wasum Mariani1 Alessandro , Mingarini Terra1 Ricardo , Manuel Pêgo Fernandes1 Paulo
Published: January 2025

Objective: Surgical resection remains the gold standard treatment for bronchiectasis in patients who present with hemoptysis or suppuration, as well as in those who do not respond to clinical treatment. We sought to investigate the efficacy of sublobar resection (segmentectomy) and compare it with that of lobar resection (lobectomy) in patients with non-cystic fibrosis bronchiectasis. Methods: Patients undergoing lobectomy or segmentectomy between 2019 and 2023 were included in the study. We analyzed intraoperative complications and postoperative outcomes, including length of hospital stay, length of ICU stay, and disease recurrence. Results: There was no significant difference between the lobectomy and segmentectomy groups regarding the occurrence of intraoperative complications such as bleeding > 1000 ml, cardiogenic shock, and ventilatory instability (p > 0.999). However, the frequency of complications was significantly lower in the segmentectomy group than in the lobectomy group (p = 0.016). Hospital stays were longer in the lobectomy group than in the segmentectomy group (16 days vs. 5 days; p = 0.027), as were ICU stays (7 days vs. 1 day; p = 0.006). There was no significant difference between the lobectomy and segmentectomy groups regarding the recurrence rate (p = 0.541). Conclusions: Early identification of bronchiectasis patients who are candidates for surgical resection is essential because those who are identified as such early on are candidates for parenchyma-sparing resections, which are similar to lobar resections in terms of disease control and lead to shorter hospital stays and better postoperative outcomes.
ATAF@15 : Perspectives d’une organisation fiscale africaine
Authors: Parry Richard , Marais Lincoln
Published: January 2025

L’Afrique est à la fois le berceau de l’humanité et le continent le plus jeune sur le plan démographique. Son avenir passionnant repose sur les talents et l’innovation de sa jeunesse, soutenus par des institutions indépendantes, telles que le Forum des administrations fiscales africaines, et l’utilisation efficace des ressources du continent. Dans ce livre, des voix africaines explorent l’évolution de l’ATAF, son impact sur l’efficacité de la fiscalité et son rôle dans l’amélioration de la vie des citoyens africains.
Elles décrivent les idées qui animent les hommes et femmes de l’ATAF dans le renforcement de la coopération et la réponse aux contraintes à travers le continent, et alimentent le rôle mondial de l’ATAF dans l’établissement de normes en matière de fiscalité. Ce récit est non seulement porteur d’espoir, mais offre également la perspective d’un avenir meilleur pour l’Afrique, tant au niveau fiscal qu’au-delà.
La force de l’ATAF réside, à l’instar du continent lui-même, dans ses hommes et femmes. Cette publication raconte leurs histoires... elle est le son de nombreuses voix africaines.
Dr Aboubakar Nacanabo, ministre de l’Économie, des Finances et de la Prospective, Burkina Faso
Ce livre rend hommage à une organisation très respectée, courageuse et fièrement africaine, et donne un aperçu de son parcours. L’ATAF est connue et appréciée pour sa vision, sa passion, sa détermination et son intégrité. Sous la direction inspirée de Logan Wort, l’ATAF s’est assuré la place qui lui revient à la table des discussions internationales sur la fiscalité et la politique, ce qui n’est pas une mince affaire. Ce livre est une oeuvre d’amour et une très bonne lecture.
Lazelle Terblanche, responsable de la fiscalité de MultiChoice Group et présidente de Africa Industry Tax Association (AITA)
...à travers cette publication passionnante, Richard Parry et Lincoln Marais ont illustré l’impact transformateur de l’ATAF sur la mobilisation des ressources intérieures. Sous la direction visionnaire de Logan Wort, l’ATAF a contribué à donner aux nations africaines les moyens de redéfinir leur rôle en tant qu’architectes de leur propre développement économique, sans dépendre uniquement de l’aide extérieure.
Alvin Mosioma, directeur associé - Prospérité économique et climatique, Open Society Foundations.
L’Afrique est le continent des récits. Les histoires racontées ici nous rappellent qui nous sommes et nous donnent le pouvoir de changer l’avenir.
Logan Wort, Secrétaire exécutif de l’ATAF
Sosialisasi Undang-Undang Nomor 7 Pasal 2 Tahun 2021 Tentang Harmonisasi Peraturan Perpajakan Untuk Siswa dan Siswi Jurusan IPS di SMAN 6 Cimahi
Authors: Setiani Tia , Maryana Diana , Casmadi Yohanes , Ramadhan Noor Surya
Published: January 2025

Pajak merupakan salah satu sumber penerimaan negara yang terbesar. Pajak terkumpul dalam APBN sebagai sumber penerimaan Negara yang digunakan untuk biaya pembangunan. Undang-Undang Nomor 7 Pasal 2 Tahun 2021 tentang Harmonisasi Peraturan Perpajakan bertujuan untuk meningkatkan pertumbuhan perekonomian serta meningkatkan kepatuhan sukarela wajib pajak. Sosialisasi Undang-Undang ini penting untuk memberikan pemahaman kepada masyarakat, termasuk siswa mengenai kewajiban perpajakan. SMAN 6 Cimahi merupakan sekolah menengah atas yang ada di kota Cimahi. Metode yang digunakan dalam sosialisasi Undang-Undang perpajakan ini yaitu dengan ceramah, diskusi, dan tanya jawab. Siswa diberikan pre test terkait dengan aturan perpajakan kemudian siswa diberikan handout berisi materi perpajakan serta dilakukan diskusi dan tanya jawab atas permasalahan perpajakan. Adapun hasil dari sosialisasi ini yaitu siswa lebih memahami aturan perpajakan, hal ini dapat terlihat dari hasil post test, siswa dapat menjawab pertanyaan dengan benar terkait materi yang disampaikan. sosialisasi Undang-Undang Nomor 7 Pasal 2 Tahun 2021 tentang Harmonisasi Peraturan Perpajakan kepada siswa adalah langkah yang baik dalam mempersiapkan generasi muda untuk memahami peraturan perpajakan dalam melaksanakan kewajiban sebagai warga negara yang bertanggung jawab.