bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Work Ecosystem on Employee Performance at the Pamekasan Regency Agency
Authors: Kamaroellah R. Agoes , Sufiyanto Mohammad Imam
Published: December 2021

The purpose of this research is to examine the paradigm change of governance implementation. The governance is the implementation of Regional Autonomy which refers to Law No. 32 of 2004 about the performance improvement of autonomous government agencies. It puts the vision, mission, and strategy into actions that confirm the success or failure levels when carrying out activities following the specified programs and policies. There are variables applied to assess the civil servants’ performance achievement. This research focused on the variables that affect the work environment, organizational culture, job satisfaction, and work motivation. The respondents of this research are officials of Echelon III and IV at 14 Autonomous Regional Agencies in the Pamekasan Regency. The number of samples in this study comprised 120 Echelon III and IV officials. Structural Equation Method (SEM) was applied to test the causal relationship between work environment variables, organizational culture, work motivation, job satisfaction, and performance with the aid of the AMOS 20.0 program. The findings indicated (1) the work environment has a significant effect on job satisfaction and performance but has no significant effect on work motivation; (2) organizational culture has a significant impact on job satisfaction and performance but has no significant effect on work motivation; (3) job satisfaction has a significant effect on performance but has no significant effect on work motivation; (4) work motivation has a significant impact on performance but it has no significant effect on work motivation.
Modern Trends in Education in the Era of Digitalization: Task and Prospects of Development
Authors: Gashimov Elchin , Pestova Veronica
Published: December 2021

The article suggests an overall review of modern technological trends in education. The authors aimed to figure out the objectives, benefits and obstacles of their development. The article deals with innovations, which have already been and are being implemented in education system with Industry 5.0 shortly ahead. The main aim is to determine social and cultural impact of rapid digitalization in the sphere of education. Research methods were based on deductive categories. Elements of descriptive and comparative analysis were applied for identification of major patterns and tendencies. The review given by the authors proves that education is one of the main challenges for authorities, teachers and students in terms of digitalization. The results of the research indicate the importance of new paradigm and reconsidering of educational environment in general. It involves technological, social and communicative aspects. Some conventional standards have become obsolete and we need to acknowledge the fact. Modern society is facing not only technological challenges but also the ones concerning attitude and skills. We can conclude that effective agreement between social and technological process can be reached if legal framework and standardized approaches are involved.
Disaster Coverage Model (DCM): Six Dimensions to Confront Activities and Workflows for Journalists and News Departments
Authors: Pellegrini Silvia , Grassau Daniela , Puente Soledad
Published: December 2021

This work aims to identify, classify, and categorize relevant activities regarding professional journalistic work in major disaster coverage, and develop a conceptual model that organizes them theoretically. We conducted a series of empirical data collection stages (background gathering through in-depth interviews and content analysis) and later applied the theory-building block approach that uses concepts to create and operationalize constructs. The main result is a six-dimension model based on the traditional questions of the journalistic process: How, why, who, when, what, and where. It comprehensively addresses the multiple aspects involved in disaster coverage: emotional, logistic, professional, and ethical challenges, as well as timing, key actors/roles, and their needs and demands according to the disaster type and stage they face. The model also brings together a group of potential activities journalists must confront and carry out when covering major disasters or highly significant social crises. Its main contribution is to make a useful theoretical tool available to academia and the media, striving for a versatile matrix management approach.
PRESCHOOL EDUCATION TEACHERS’ EVALUATIONS ABOUT THE PROBLEMS EXPERIENCED IN THE EDUCATION PROCESS AND THEIR SOURCES
Authors: Erişti Bahadır , Avcı Fatma
Published: December 2021

The aim of this research is to reveal the evaluations of preschool teachers’ about the problems experienced in the education process and the sources of the problems. The study was carried out based on the basic qualitative research design. The research participants consist of 19 preschool teachers working in public and private schools providing preschool education in Eskişehir city center. The primary data of the research were obtained through semi-structured interviews with teachers. In addition, the parent demographic information collection forms and the researcher diaries were used. Descriptive analysis and content analysis were used in the analysis of the data. According to the main findings obtained within the scope of the research, the most frequent and common problems experienced by students in the education process are related to attention and maintaining attention, and exhibiting behaviors in accordance with the rules in the classroom. In addition, the problems experienced are observed much more intensely in male students compared to female students. When teachers compare their students from past years with their current students, they are of the opinion that there is a significant increase in the problems experienced in the education process compared to years. Problems experienced in the preschool education process occur more frequently and are more common in public schools compared to private preschool education institutions. The most important sources of problems behind the troubles that arise in the education process; students’ parents, common technology usage habits of students, quality of teachers, quality of educational environments, preschool education program, student characteristics and changing daily life habits of students.
Epidemiological profile of hospitalizations for epilepsy in Northeastern Brazil
Authors: Moraes João Victor Queiroz , Brito Lucas Andrade , Albuquerque Lucas Vieira de , Bezerra Samuel Sales , Oliveira Diego Menezes de , Costa Júnior Antônio Luís Rodrigues
Published: December 2021

Background: Epilepsy is a temporary and reversible change in brain function, which is not caused by fever, drugs or metabolic disorders, and its different symptoms may require hospitalization for seizure control. Objective: To describe the epidemiological profile of patients with epilepsy hospitalized in Northeastern Brazil, from 2011 to 2020. Design and setting: This is an ecological study placed in Northeastern Brazil. Methods: Data were obtained from Brazilian Health Informatics Department - DATASUS (Hospital Information System). Epilepsy was the morbidity selected. Data were collected by year, age, sex and state and processed through Microsoft Excel. Results: There were 108,804 hospitalizations for epilepsy in Northeast Brazil from 2011 to 2020 (mean annual: 10,880.4 ± 1,653.7). There were most hospitalizations for epilepsy in 2019 (12.7%, n=13,806) and the lowest in 2012 (8.1%, n=8,842). An increase was noticed from 2012 to 2019, followed by a 13.8% decrease in 2020 (n=11,803). Males were most hospitalized (58.7%, n=63,900). Children between 0 to 9 years (38.6%, n=41,998) were the most hospitalized, followed by 10 to 19 years (13.8%, n=15,025), whereas eldery aged 80 years or older were the least frequently hospitalized (3.6%, n=3,917). Bahia (27.7%, n=30,120) and Pernambuco (27.6%, n=30,037) showed the highest ratios of hospitalizations, while Sergipe recorded the lowest ratio (2.3%, n=2,499). Conclusion: Hospitalizations for epilepsy in Northeastern Brazil from 2011 to 2020 were most frequently in males, aged 0 to 9 years, living in Bahia.
Neurological manifestations associated with SARS-CoV-2 infection: a narrative review
Authors: Araújo Poliana Rafaela dos Santos , Madruga Kauan Alves Sousa , Rocha Bruna Alves , Braga Lucas Oliveira
Published: December 2021

Background: Coronavirus disease (COVID-19), once identified, soon spread globally, becoming a pandemic. Although patients present mainly with respiratory complaints, several neurological symptoms have been reported. Symptoms range from headache and nonspecific dizziness to seizures and cerebrovascular disease (CVD). It has also been shown that the severity of the infection is directly proportional to the development of neurological symptoms, especially CVD and changes in mental status. Objective: The present study aims to briefly review the neurological manifestations of COVID-19 and discuss the pathogenic mechanisms of Central Nervous System (CNS) involvement. Methods: This is an exploratory narrative review with a descriptive approach, consisting of an active search for scientific articles in the PubMed database. The descriptors “coronavirus infections”, “COVID-19” and “Nervous system” were used, with the Boolean operators “OR” and “AND”. Eighteen articles of systematic review and meta-analysis were included. Results: CNS manifestations included, among others: encephalitis, encephalopathy, consciousness decrease, headache, dizziness, acute myelitis, and stroke. As for the peripheral nervous system, skeletal muscle damage, chemosensory dysfunction, and Guillain-Barré syndrome were observed, with hyposmia being the most common symptom. CNS involvement may be related to a worse prognosis. Conclusion: The clinical involvement of the nervous system in COVID-19 is not uncommon, and can result in several neurological complications, especially in the most critical patients. The pathophysiological mechanisms of these events still need further investigation. In the meantime, physicians should value extra-respiratory symptoms ranging from hyposmia, to potentially fatal manifestations, such as stroke and encephalopathy.
Can depression be associated with the immune response
Authors: Lenhardt Maurício Machado , Schwartz Dauana , Silva Bruna K. de F.
Published: December 2021

Introduction: Depression is a disease of uncertain installation and etiology, the imbalance of neurotransmitters is involved in this process, and stress can be an activator of pro-inflammatory cytokines and trigger depressive symptoms. The organism undergoes modulations due to biochemical changes and these are linked to molecular and biochemical components and by the survival instinct, the human body is stimulated to release substances as a form of protection. The objective of this study is to describe the possible association between a loss of homeostasis of the central nervous system (CNS), changes in the modulation of the immune system, and the development of depressive symptoms. Methods: This is an integrative literature review, available in the virtual health databases: PubMed, MEDLINE, SciELO, and Google Scholar published between the years 2010 to 2020. Results: Studies indicate that cytokines can interfere with the homeostasis of the CNS and that the imbalance of catecholamines and indoleamine is involved in the process of depression. In this sense, studies have focused on neuromodulation by blocking neurotransmitters and neuroreceptors to regulate the immune system. Conclusion: It’s already established that the imbalance in the release and reuptake of neurotransmitters is associated with the onset of the depression, however, current studies show that there may also be an association with the homeostasis of the immune system. Therapeutic protocols aren’t based on the correlation between the immune system and the onset of the disease, so further studies are needed to strengthen this relationship.
Bilateral papillitis secondary to Neurosyphilis in an immunocompetent patient - Case report
Authors: Borges Érico Induzzi , Fernandez André Lopez , Almeida Louis Fernando Marques de , Teixeira Rebecca Vieira , Soares Neto Herval Ribeiro , Silva Sônia Maria Cesar de Azevedo
Published: December 2021

Context: Syphilis is a pleomorphic, insidious disease and an important differential diagnosis of ocular and CNS involvement. Its recognition and treatment are extremely important, given the high morbidity of its natural history. Case report: A 79-years-old woman started bilateral, intermittent and progressive visual turbidity, evolving in 5 months with pain on eye movement and intense throbbing bilateral headache, worse on the right, plus photophobia, and poor painkillers response. After 3 months, she presented fleeting amaurosis and was admitted to our service. On examination: severe low visual acuity, relative afferent pupillary defect, red desaturation and papilla edema. In CSF: hyperproteinorrachia and negative VDRL. Prednisone 60mg/day was started due to papillitis. Blood analysis showed 1/8 reagent VDRL, with other serologies, tumor and rheumatology markers negatives. She received crystalline Penicillin for 14 days, obtaining remission of headache, papilla edema and improved visual acuity. After 12 days, the visual acuity worsened, so Penicillin was extended to 21 days with 7g of methylprednisolone. After 3 days, the patient recovers the visual acuity she had before. Conclusions: The present study describes neuro-ophthalmological manifestation of syphilis in an immunocompetent individual. Although there is still controversy in the literature, in this case, high dose short-term corticoids was chosen, due to the severity of the loss of visual acuity, obtaining a favorable therapeutic response.
Analysis of stroke treatment outcomes in hospital setting in Brazil, between the years 2010 and 2019.
Authors: Sousa Giovanna Carvalho , Barreto Gustavo Bomfim , Loula Lanna Victória , Lordêllo Louise Seixas , Vilas-Boas Gustavo Sampaio , Lima Raíssa Barreto , Oliveira Lara Teixeira de , Azevêdo Beatriz Gusmão , Carvalho Thaís Machado Belitardo de , Oliveira Isadora Abreu , Fonseca Rafaela Sandes , Rios Ana Carolina Pacheco de Menezes , Souza Matheus Campos Ribeiro de
Published: December 2021

Background: Stroke is an important cause of death and is a major cause of serious disability in Brazil and in the world. Therefore, it is fundamental to analyze its treatment in the hospital setting in Brazil. Objectives: To describe the progression of the stroke treatment in the hospital setting in Brazil between the years 2010 and 2019 and the outcomes associated to the disease. Design and Setting: Transversal, retrospective and quantitative study, with secondary data collected in the Hospital Information System of SUS (SIH / SUS) between 2010 and 2019, in Brazil. Methods: Data from number of hospitalizations for stroke treatment, mortality rate and average length of hospital stay were collected and analyzed. A comparison has been made between these data over the selected years. Results: The number of hospitalizations for stroke treatment had a 16,83% growth between 2010 and 2019. In comparison, the average length of hospital stay was 7,7 days in 2010 and 7,6 days in 2019. The mortality rate had a reduction of 10,52% between these years. Conclusions: Despite the growth of hospitalization to stroke treatment, there was a reduction in the average length of hospital stay and in the mortality rate associated to the procedure. It is possible to infer an optimization in the stroke lead in intensive care units in Brazil.
Proportion of male and female professionals in neurosurgery
Authors: Kalkmann Gabriela Ferreira , Floriano Luíza , Menezes Têka Luila Borgo , Zago Sonia Quézia Garcia Marques , Martins Laura Beatriz , Spenazato Júnior Valdecir Boeno , Angelo Isabella Carla Barbosa Lima , Góis Jennifer Tuane Felipe de , Santiago Nathally Marques , Lages Gustavo Veloso , Rossi Thania Gonzalez
Published: December 2021

Introduction: The specialty of neurosurgery over time has become increasingly sought after. Even with the gradual increase in women specialists in neurosurgery, they are still represented by a very small number in comparison to the number of male neurosurgeons. Objectives: Present the gender gap within neurosurgery. Methods: This is a systematic literature review, with the search terms: “gender” AND “women” AND “Neurology” AND “Neurosurgery”, resulting in 645 articles on the Pubmed, Lilacs, Scielo, Cochrane and TripDataBase search platforms. The inclusion criteria were: original studies published in any language. Published articles that prevented full access, as well as systematic reviews or not, were excluded. After applying the inclusion and exclusion criteria, 6 articles were included. Results: The databases of the American Association of Neurological Surgeons (AANS) and American Board of Neurological Surgery (ABNS) revealed that women represent only 12.0% of residents in neurosurgery. Most of them left training in the first 3 years and remained in Medicine, looking for other specialties. In addition, the female conflict rate with the team was 17.0% compared to a 5.3% male rate. The low number of women in neurosurgical residency programs can result in a consequent decrease in female tutors, lack of rise in female professionals and non-adherence of medical students in residency programs. Conclusions: The percentage of women in medicine has increased in recent years, however the number of women who pursue a neurosurgical career is still very small, when compared to the total number of neurosurgeon men.
Reversible brain vasoconstriction syndrome associated with intoxication by marijuana, ether and chloroform
Authors: Rossette Vanessa Moraes , Barreira Raphael Palomo , Torres Thomas Zurga Markus , Correa Beatriz Medeiros , Marques Thiago da Cruz , Miyahira Clara Kimie , Miranda Natalia Figueiredo , Cutolo Natasha Soares , Costa Fernando Pierini
Published: December 2021

Context: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by reversible narrowing of brain vessels. It affects young adults, predominantly female, with acute and self-limited course, initiated with “Thunderclap” headaches associated or not with neurological symptoms, such as seizures and focal deficits. Pathophysiology is the dysfunction in the control of the sympathetic autonomic nervous system through a multifactorial mechanism with a strong association with hormones, immunological, biochemical and other predisposing factors, including drug addiction, with emphasis on marijuana, ether and chloroform. Case report: A 19-year-old female started with an insidious acute clinical condition of severe holocranial headache after using marijuana and “loló” (chloroform and ether narcotic), evolved with behavioral and level of consciousness alterations, admitted in status epilepticus, being orotracheal intubation (OTI) is required. No comorbidities. Neurological examination: OTI and sedated, at RASS-2, slowed trunk reflexes and global weakness (Grade 3). Skull tomography: Hyperdense foci in splenium of the corpus callosum and cingulate gyrus. Cerebral angiography: mild to moderate cerebral vasospasm evident in the P1 and P2 segments of the posterior cerebral arteries, suggestive of RCVS. Conclusion:The diagnosis is clinical and radiological, with cerebral angiography being the gold standard. Vascular involvement such as intraparenchymal hemorrhage, non-aneurysmatic subarachnoid hemorrhage and cerebral infarction are common. Toxicological tests help in the investigation, and the exclusion of the precipitating cause is important, in addition to drug therapy that prevents recurrence of vasospasm. The improvement can occur in up to three months, in our case the evolution with neurological improvement was evident after one month.
Arterial hypertension and cerebrovascular accidents. epidemiological profile of patients attended between 2013 and 2019 in Joinville, Santa Catarina, Brazil
Authors: Daudt Pedro Eugênio Deboni , Jardim Alexandre Grunfeld Starling , Reis Felipe Ibiapina dos
Published: December 2021

Introduction: Cerebrovascular accident (CVA) is the second cause of death in the world, and arterial hypertension (AH) is the main risk factor. Objectives: To evaluate the prevalence of AH and the epidemiological profile of patients who suffered CVA, first and recurrent events, registered at JOINVASC, between 2013 and 2019. Methodology: An observational, descriptive, retrospective study, analyzing demographic data and risk factors, in patients that suffered CVA, first or recurrent event, was done. Results: In the study period, 6057 CVA events were registered, 4402(72.6%) patients were classified as hypertensive, (122 were excluded due to incomplete data), 4387 registers were analyzed. In this group, 2149 (51.2%) were male, mean age was 68.4±14.7(18 a 102 years), BMI was 27.5±5.1(14 a 59), 4330(39.9%) with Diabetes, 2559(58.8%) were smokers or ex-smokers, 3174(7.42%) were sedentary, and 504(11.5%) had controlled AH. In the group with recurrent event (1392-31.7%) (52.3%, p<0.001) were females, mean age was (69.4± 11.5) (p<0.002); BMI was lower (p=0.02). There was more cardiopathy (47.6%) (p<0,001) ,smokers or ex-smokers (66.2)(p<.005), diabetes (46.7%) (p<0.001) and deaths (32.3%)(p<0.001), less physical activity (22.0%)(p<0.001), use of antihypertensive drugs was greater (1.52±0,93)(p<0.001),. Logistic regression showed that female sex, BMI, DM, cardiopathy, physical activity, and more anti- hypertension drugs, were significant predictors for recurrence of neurologic event. Discussion: Despite advances in primary health care and prevention campaigns, the prevalence of AH in patients with CVA is high, and still has lowlevels of control, even in patients with recurrent CVA.
Benefits of post-stroke telerehabilitation
Authors: Granato Maria Julia Filgueiras , Fabri Júlia Campos , Oliveira Maria Luiza Franco de , Rezende Maria Clara Lopes , Campos Leandro Vespoli
Published: December 2021

Introduction: Stroke was responsible for 139.4 million cases of global disability in 2019, many of which require rehabilitation. Telerehabilitation has emerged as a promising remote therapy aimed at improving the deficits resulting from stroke. Objective: To compare the benefits of telerehabilitation with the usual methods of rehabilitation in post-stroke patients. Methodology: In April 2021, a literature review including systematic reviews of studies in humans, available in full and published in the last 5 years was executed on MedLine using the descriptors “stroke”, “telerehabilitation” and their MeSH variations. Results: The first selected article revealed that post-stroke telerehabilitation resulted in less expenses and was associated with comparable improvements to the standard treatment group in the recovery of motor deficits, cortical dysfunction and depression. The second review concluded that telerehabilitation was equal to or greater than usual rehabilitation for improvements in daily living and psychological status and restoration of quality of life and motor performance. The third study found that telerehabilitation achieved similar results to face-to-face therapy and usual care on improving daily life. The fourth article reinforced the benefits of telerehabilitation on several outcomes, although current evidence is limited. Conclusion: Telerehabilitation can be an adequate alternative to the care of post-stroke patients, however, further studies are needed to establish the benefits it provides.
Septic Cavernous Sinus Thrombosis due to Pneumococcal Meningitis in A 6 Months Infant
Authors: Madruga Kauan Alves Sousa , Lima Luiz Fernando Melo , Araújo Pedro Victor Oliveira , Carvalho Vitória Bittencourt de , Borges Bruna Da Cruz Beyruth
Published: December 2021

Context: Septic Cavernous Sinus Thrombosis (CST) is a rare and potentially lethal illness that clinicians still occasionally see. We describe the evolution of a 6 months old infant patient who had a history of delayed vaccination and acquired a Pneumococcal Meningitis, leading to septic CTS. Case report: The patient was admitted with the complaint of constant crying and vomiting. The physical exam noticed: bulging of the bregmatic fontanelle, Glasgow Coma Score = 11, and bad general state. The clinical picture had begun one week before the hospitalization, but the fever had started just three days before. The vaccine neglection plus some pathological signs of meningeal infection guided the clinical thinking to meningitis, later confirmed by the lumbar puncture. Some days later, the patient presented paralysis of the third pair of cranial nerves, conducing to the inability to open the eyes, mydriatic non-photo reagent pupils, and bilateral swelling. A magnetic resonance confirmed thrombosis of traverse sinus along with the transition to the sigmoid one. Bilateral ptosis and exotropia were noticed. Antibiotic therapy resulted in progressive eye-opening and recurrence of photo reagent reflexes. The prognosis was great, pointed by the normotension and normal amplitude of the bregmatic fontanelle. Conclusion: The elimination of the meningeal infection focus was extremely important, since the pathophysiology of CST came from phlebitis of the cavernous sinuses, with consequent thrombus formation from the endothelial lesion. In addition, it is worth mentioning the omission of vaccination, which was concessive to the case.
Analysis of physical activity level and sedentary behavior before and after stroke: A cross-sectional study
Authors: Souza João Victor de Araújo , França Monalisa Silva de , Pereira Nayara Karina Ferreira , Araújo Denise Soares de , Cacho Roberta de Oliveira , Carvalho Adriano Araújo de , Fonseca Adna Karolinne
Published: December 2021

Introduction: Stroke is a major cause of death and mortality worldwide. The sedentary lifestyle is a modifiable risk factor and the regular practice of physical activity can reduce the recurrence of stroke and its symptoms. Objective: To characterize the level of physical activity of post-stroke patients before and after the event. Methodology: This is a cross-sectional, analytical study. The population of the study consisted of patients diagnosed with stroke, in the chronic phase under treatment or that have already been discharged from the Physiotherapy School Clinic of FACISA in Santa Cruz-RN. The individuals were evaluated by the Modified Baecker Questionnaire for the Elderly (QBMI) that classifies the level of physical activity in: sedentary (-9), active (9 to 16), and athletes (+16). The normality of the variables was verified by the Shapiro-Wilk test. Wilcoxon’s test was used for comparative analysis of QBMI before and after stroke. Results: Nineteen patients participated (8 male and 11 female) with a mean age of 63 years, of these, 11 had systemic hypertension. Before, 3 were classified as sedentary (score mean: 5.34), 5 active (score mean: 12.254) and 1 athlete ( score mean: 27.04). After the stroke, 18 were classified as sedentary (score mean: 1.46) (p=0.001). Conclusion: There was a reduction in the participants’ level of physical activity, showing greater sedentariness after stroke, although physical activity is essential for secondary prevention of stroke.
Phantom pain: pathophysiology and therapeutic approaches
Authors: Bernardo Juliana Matos Ferreira , Gomes Artur Bruno Silva , Sá Felipe Jatobá Leite Nonato de , Ferreira Júlia Gonçalves , Silva Maria Rosa da
Published: December 2021

Background: Phantom pain is a mentally debilitating neuropathy that affects post-amputees. It interferes with the independence and performance of activities, therefore affecting the quality of life. Its pathophysiology ranges from lesions in peripheral innervations, to spinal functional changes, modulation of cortical circuits and psychological factors Objectives : Demonstrate new therapeutic approaches and establish a relation with the pathophysiological mechanisms. Methods: Integrative review applying the descriptors: “phantom pain”, “physiopathology”, “post amputation pain”, “treatment”, and the Boolean operator AND. The searches were carried out at PUBMED with 142 results, at BVS with 113, and at Scielo ,showing no results. At the end, 9 papers were selected. No linguistic filters were used and articles published between 2016 and May 2020 were incorporated. Results: (1) Motor images, mental and visual representation of the limb and its function; (2) peripheral interfaces enables prosthetic control; both techniques active cortical reorganization by promoting sensory feedback to motor stimuli. (3) repetitive transcranial magnetic stimulation and (4) direct current, a non-invasive approach, for maladaptive cortical neuromodulation, in addition to stimulate peripheral innervation. In surgical interventions, (5) targeted muscle reinnervation is used in the residual nerves on amputation process to reinnervate the motor terminal of the remaining muscles, promoting nerve growth and organization. Conclusions Physiological investigation applied to treatments enables effective therapeutics, anticipating rehabilitation. The representation of images, peripheral interfaces, brain stimulation and less invasive surgical techniques.
Impact of the COVID-19 pandemic on coping with Leprosy in Sergipe, Brazil, 2020
Authors: Silva Rômulo Rodrigues de Souza , Matos Thais Silva , Silva Tarcísio Fulgêncio Alves da , Carmo Rodrigo Feliciano do , Santos Márcio Bezerra , Correia Divanise Suruagy , Machado Michael Ferreira , Marques Carolinne de Sales , Araújo Amanda Karine Barros Ferreira de , Fernandes Tânia Rita Moreno de Oliveira , Souza Carlos Dornels Freire de
Published: December 2021

Background: The COVID-19 pandemic had an impact on the dynamics of other existing diseases in Brazil, such as Leprosy. Objectives: To analyze the impact of the COVID-19 pandemic on leprosy indicators in the general population and in children under 15 in the state of Sergipe, in 2020. Methods: An ecological time series study was carried out including all new cases of leprosy diagnosed and reported in the state of Sergipe between 2017 and 2020. The variables were analyzed: i. Number of new cases, monthly average and detection coefficient in the general population and in children under 15 years old/ 00 thousand inhabitants, ii. Proportion of ignored / blank / unclassified in the epidemiological variables, iii. Proportion of contacts of new leprosy cases that were examined during the year. A descriptive analysis was conducted. Results: In 2020, there was a 22.2% reduction in the number of new leprosy cases in the general population (325 in 2019; 253 in 2020) and a 44.4% reduction in the general detection coefficient (14.1/100 thousand in 2019; 7.9 cases/100 thousand in 2020). In children under 15 years old, there was a 50.0% decrease in records (22 cases in 2019; 11 cases in 2020) and 49.8% in the detection coefficient (4.2/100 thousand in 2019; 2.1/100 thousand in 2020). The number of municipalities without a record of the disease increased, both in the general population, which went from 25 (33.3%) municipalities in 2019 to 29 (38.6%) in 2020, and in those under 15 years of age, from 63 (84.0%) to 68 (90.7%). There was an increase in the proportion of ignored/ blank/ unclassified fields in the variables race/color, education, clinical form and assessment of physical disability in the diagnosis. The contact examination decreased from 78.7% to 68.9%. Conclusions: The COVID-19 pandemic resulted in a negative impact in the fight against leprosy in Sergipe. The challenges posed by the pandemic must urgently be considered in the development of mitigation plans and or strategies.
Myopathy following statin use
Authors: Carvalho Ana Cláudia Pires , Dias Fernanda Rezende , Costa Luisa Crevelin , Nakao Natália de Castro Fim
Published: December 2021

Introduction: Myopathies can be caused by various drugs, including statins and corticosteroids, and can be toxic or inflammatory, one example being necrotizing myositis triggered by statins. Objectives: Describe the case of a patient with weakness after statin use. Design and setting: Case report Methods: Analysis of medical record, photographic record of the diagnostic methods and literature review. Case description: 69-year-old female, obese, hypertensive, diabetic, dyslipidemic and hypothyroid, taking atorvastatin since 2017, referred by endocrinology for generalized myalgia in 2019, with increased creatine phosphokinase (CPK). Discontinued statin use since then, maintaining symptoms. Neurological examination showed tetraparesis, with proximal predominance. Electroneuromyography (ENMG) showed signs of myopathy. Corticotherapy with deflazacort was initiated, with improvement of symptoms and reduction of CPK levels. Investigation for paraneoplastic syndrome was performed, with negative results. He started using pioglitazone, prescribed by endocrinology, with reduced corticotherapy, for better glycemic control, presenting worsening weakness, frequent falls, and dyspnea on effort. The patient repeated ENMG in one month, without changes. Performed an anti-HMG-CoA reductase autoantibody test, with a positive result, concluding the diagnosis of immune-mediated necrotizing myositis triggered by statins, with a probable toxic myopathy after use of pioglitazone. Azathioprine was introduced, with gradual weaning from corticosteroids, and physical therapy was started. Conclusion: Several medications can cause myopathy, directly (toxic) or indirectly (immune-mediated), and this patient used 3 potentially myopathy-causing drugs (atorvastatin, deflazacort, and pioglitazone). The nonimprovement upon medication withdrawal suggested an immune-mediated inflammatory cause, confirmed in this case by the determination of a specific autoantibody for statin-induced necrotizing myositis.
Sífilis materna no Brasil
Authors: Paiva Daniele , Ramos Amanda , Lima Sérgio , Costa Ilka , Reis Ana Paula
Published: December 2021

Introdução: A sífilis é uma doença sistêmica causada pela bactéria Treponema pallidum, transmitida principalmente pelas vias sexual e vertical. É considerada um grave problema de saúde pública, principalmente nos últimos dez anos. A assistência pré-natal pode proporcionar o rastreamento oportuno e o tratamento eficaz de sífilis em gestantes. Objetivo: Apresentar a taxa de detecção de sífilis em gestantes no Brasil. Métodos: Estudo descritivo, retrospectivo e transversal sobre sífilis em gestantes no Brasil no período de 2010 a 2019, com análise de dados coletados do Sistema de Informações em Saúde do Departamento de Informática do Sistema Único de Saúde. Resultados: O número de casos de sífilis em gestantes apresentou um aumento gradativo no período de 2010 a 2018, demonstrando uma leve redução em 2019. A taxa de detecção de gestantes com sífilis para cada 1.000 nascidos vivos foi de 3,5 em 2010 para 21,5 em 2018 e 20,8 em 2019. No período em estudo, foram notificados 332.951 casos de sífilis em gestantes, sendo a maioria na faixa etária de 20 a 29 anos (52,8%) e parda (48,5%). Em relação à fase clínica, foi observada maior detecção de sífilis primária em 2010 (37,6%), diminuindo para 25,1% em 2019, enquanto a fase latente aumentou de 14,8% em 2010 para 37,8% em 2019. O mesmo transcorreu com o trimestre gestacional do diagnóstico, no qual o primeiro trimestre era o menos frequente em 2010 (21,7%) e tornaou-se o mais frequente em 2019 (38,7%). Conclusão: A sífilis em gestantes apresentou um aumento de sua taxa de detecção no decorrer do período em estudo. A maior frequência do diagnóstico de sífilis nas fases latentes e no primeiro trimestre gestacional pode ser resultante de melhorias do pré-natal, ratificando sua importância na assistência materna.
Reklam Metninde Gerçe(kli)ğin İnşa Süreci: Göstergebilim, İletişim, Sosyoloji ve Felsefe Kuramlarının Düşüngü Ekseninde Kavramsal ve Kuramsal Bir Eleştiri
Authors: TUNCER Esra Saniye
Published: December 2021

Reklamlarda “gerçeğin inşa ideolojisi”nin farklı konumlandırmalarına şahit olmaktayız. Reklam, kurgusal söylemiyle gerçek yaşamı dönüştürmekte, gerçeği yeniden inşa etmektedir. Bu çalışmada temelde, iletişim olgu ve sürecine dahil olan popüler kültür ürünü/üreticisi reklam metinlerinin /iletilerinin kurgusal gerçeklik bağlamında kuramsal bir değerlendirmesi yapılmaktadır. Çalışmada, reklam metinlerinin göstergebilimsel kuram ve reklam söylemi üzerinden gerçeğin inşa ediliş sürecinin görünümlerine ilişkin birtakım tespitlere varılmıştır. Bu tespitlerin, reklam araştırmaları ve göstergebilimsel reklam çözümlemeleri (reklam göstergebilimi) alanında yapılan çalışmalara ışık tutacağını ve alana farklı bir bakış açısı kazandıracağını umut etmekteyiz/amaçlamaktayız. Günümüz patriarkal toplumsal ve kültürel yapıdan doğan mitler ile toplumsal yapılanmaya yansıyan reklam mitleri arasındaki ilişki, gerçekliğin inşa ediminde şekillenmektedir. Bu bakış açısının reklam göstergebilimi alanında süregelecek çalışmalara ivme kazandıracağı kanaati, çalışmanın önemini gözler önüne sermektedir.
Çalışmada, reklam metinlerinde “gerçekliğin ideolojisi” üzerine geleneksel mitlere uygun (s)imgelere yer verildiği ve bu (s)imgelerin reklam metninde gerçeği inşa ettiği / ürettiği ve yeniden inşa ettiği / ürettiği saptanmıştır. Reklamda kurgulanan gerçeklik, tüketiciyi manipüle etmektedir. Diğer bir deyişle, reklamın kurgusal gerçeği içinde işleyen ideoloji, insanın birbirleri ve dünya ile olan ilişkilerini manipülasyona uğratarak yeniden üretmektedir.
Sonuç olarak denilebilir ki; reklamlar, içinde üretildikleri toplumsal ve kültürel yapının değerlerini yansıtırken aynı zamanda onları (gerçeği) yeniden üretmekte, inşa etmektedir.
Öfke Çağ'ında Göçmenin Yolculuğu: Baran, Daha ve Amerika Square Filmlerinde Göçmene Yansıtılan Öfke
Authors: MIZIKACI Müberra
Published: December 2021

Göç hareketlerinin 2000’li yıllardan bu yana kitleselleşmesi, göç alan tüm toplumlar için göçmene karşı duyulan öfke hissinin artmasına neden olmuştur. Bu çalışmanın amacı, göçmene karşı duyulan öfkeyi İran sinemasından Baran (Majid Majidi, 2001), Türk sinemasından Daha (Onur Saylak, 2017) ve Yunan sinemasından Amerika Square (Yannis Sakaridis, 2016) adlı filmler aracılığı ile incelemek ve siyasal yapıdaki söylemin bireyler üzerinden göçmene nasıl yansıtıldığını araştırmaktır. Öfke Çağı terimi kullanılırken Pankaj Mishra’nın Age of Anger – A History of the Present adlı kitabında vurguladığı; kapitalizmin yarattığı düzensizlik ve şiddetin öfkenin kaynağı olduğu varsayımı kabul edilmiş, seçilen filmlerin alt metinlerinde de bu ekonomik düzensizlik gerçeği aranmıştır. Araştırma için göç ile ilgili istatistikler, ilgili ülkelere ait dönemsel göç ve siyasi haberler taranmıştır. Göç olgusu beraberinde getirdiği öfke duygusu ile birlikte artarak devam etmektedir. Baran, Daha ve Amerika Square’deki özneler, ait oldukları, kültürel, ekonomik ve siyasal ortamının bakış açısı ile göçmeni bir öfke nesnesi olarak kullanmaktadır.
Desenvolvimento e validação do sistema Mining_RNA
Authors: Moreira Carlos Renan , Pacheco Christina , Pereira Diógenes Marcos Vinícius , Maia Leite Cicília Raquel
Published: December 2021

O sequenciamento do genoma humano proporcionou o aprofundamento de diversos tipos de estudos e tecnologias de análise biológica, dentre estas, o microarranjo. A necessidade publicar os dados brutos dessas pesquisas impulsionou a criação de bancos de dados públicos onde essas informações pudessem ser indexadas e resgatadas. Essas bases são uma grande fonte de dados transcriptômicos que infelizmente acabam sendo subutilizadas. O objetivo deste trabalho foi o desenvolvimento de um sistema WEB para mineração de dados em estudos transcriptômicos a partir de microarranjos armazenados no banco de dados biológico Gene Expression Omnibus (GEO), o Mining_RNA. Através de uma usabilidade passo-a-passo juntamente com uma série de filtros o sistema possibilita resgatar dados do GEO, calcular a expressão diferencial entre os genes de um estudo, possibilitando ainda análises estatísticas para cada gene do estudo analisado. O sistema foi validado através da comparação com a avaliação dos mesmos dados com o software GEO2R (eficácia aproximada de 98%) e no estudo original (eficácia maior que 90%). Mining_RNA pode ser um forte aliado dos pesquisadores para a reanálise de estudos transcriptômicos, possibilitando uma nova forma de analisar os dados e gerando resultados tão confiáveis quanto ferramentas já consolidadas.
INIȚIATIVE ALE SECRETARILOR GENERALI AI ONU, CA RĂSPUNS LA PROVOCĂRILE MEDIULUI DE SECURITATE INTERNAŢIONAL
Authors: COJAN Nicușor
Published: December 2021

În decursul istoriei sale, Organizația Națiunilor Unite (ONU) s-a dezvoltat și a încercat să se adapteze pentru a putea răspunde provocărilor mediului de securitate internațional. Societatea contemporană este compusă dintr-un complex de entități economice, politice, culturale, religioase etc., aflate într-o continuă evoluție sau transformare, care generează noi și noi provocări la adresa însăși a existenței umane. În acest context, am considerat utilă evidențierea unor inițiative, documente fundamentale și politici întreprinse de ONU, de la apariție și până în prezent, menite să răspundă la cât mai multe dintre provocările din mediul de securitate internațional, în încercarea de a crea o lume mai bună, demonstrând rolul important al secretarilor generali în evoluția și dezvoltarea organizației.
RELATIONSHIP BETWEEN PERCEPTION AND RESPONSIBILITY WITH COMMUNITY PARTICIPATION IN MANAGING COVID 19 IN CIPONDOH DISTRICT, TANGERANG CITY
Authors: M I Suhifatullah  , Widodo  , Yunani  , Edi Mulyadi
Published: December 2021

The results to be obtained in the research are the relationship between public perception and community participation in overcoming Covid 19, the relationship between responsibility and community participation in overcoming Covid 19, as well as the relationship between perception and responsibility together with community participation in overcoming Covid 19. This research is correlational quantitative, involving 100 community members in the RW. 08 Cipondoh Village, Cipondoh District, Tangerang City, which was selected by means of Proportionate Random Sampling. Data were obtained through a calibrated questionnaire. From the research, data obtained: (1) that public perception has a positive and significant relationship with community participation in handling Covid 19, with a value of ry.1 = 0.731 >rtable (rtable = 0.195 at = 0.05 and rtable = 0.256 at = 0.01). (2) that responsibility has a positive and significant relationship with community participation in the response to Covid 19, with a value of ry.1 = 0.661 >rtable (rtable = 0.195 at = 0.05 and rtable = 0.256 at = 0.01). (3) that public perception and responsibility together have a positive and significant relationship with community participation in the prevention of Covid 19, with a value of ry.1 = 0.808 >rtable (rtable = 0.195 at = 0.05 and rtable = 0.256 at = 0.01).
SEMIOTIC ANALYSIS OF THE POLITICAL COMMUNICATION PATTERNS OF JOKO WIDODO AND NAHDLATUL ULAMA IN THE 2019 PRESIDENTIAL ELECTION CAMPAIGN
Authors: Achmad Nafhis Ubaydillah  , Effy ZalfianaRusfian
Published: December 2021

Semiotics is used as the basis for the meaning contained in each message, especially regarding political communication which uses a reference that every message meaning is contained in it. A political communication that uses the interactional communication model carried out by Joko Widodo and Nahdlatul Ulama convinces the public to support Joko Widodo as a candidate for President of Indonesia in 2019. Semiotics has a relationship with the prevailing culture in an area due to signs and patterns of political communication. carried out by Joko Widodo and Nahdlatul Ulama is believed to be a communication process and uses signs and figures of speech through the metaphor of political communication by referring to the communication made between the two actors to participate in seeing the communication process by sending messages to the public. Semiotics is used in a message as well as to be sent to the public. The campaign carried out by Joko Widodo has a close relationship with Nahdlatul Ulama as the two of them did to believe in all Indonesian people with the messages sent by both of them. However, the semiotic element contained in the political communication carried out by Joko Widodo and Nahdlatul Ulama invites the Indonesian people to follow what is done by interpreting the meaning of semiotics in the political messages sent by Joko Widodo and Nahdlatul Ulama to the Indonesian people.
THE ROLE OF SMALL AND MEDIUM ENTERPRISES (SME) ON THE ECONOMY
Authors: Reswita  , Andi Irawan  , Ketut Sukiyono
Published: December 2021

SME is the productive economic activity widely occupied by the people to sustain their household economy, community, and nation's economy. The SME sector can stand firmly as one of the economic prime-movers for many circles within the community, providing and absorbing workforce to decrease unemployment in the society. The presence of SMEs can also provide added value on farming products so that the farming commodity may increase its usefulness value.  This article aims to discuss the role of SMEs in the Indonesian economy. The research method implemented in arranging this study is a literature study by reviewing articles published by the previous writers and examining the abstract of those researches. Based on the literature study, this research concluded that SME presence, either internationally, nationally, or developing economic growth in various regions in Indonesia. The SME has the crucial meaning and roles for developing and increasing the income (PDB and PDRB), provider and employee/workforce, diminishing poverty rate, increasing investment rate, increasing foreign commerce through export, and contributing tax as the state income sources.
Media Language Planning During a Pandemic – the Influence of Covid-19 on Language Recommendations to Swedish Media in Finland
Authors:   University of Helsinki, Stenberg-Sirén Jenny
Published: December 2021

A global crisis, like the Covid-19 pandemic, can change not only societies but also languages by a great input of new terminology. For speakers of a minority language, media is in a key position to provide them with these new words in their own language. In the case of Finland-Swedish, the Swedish media in Finland is helped by professional language advisers in this language planning task. This study analyses the media language management in Finland-Swedish media, through a content analysis of language recommendations published between February 2020 and April 2021, as well as interviews with media language advisers. The analysis shows that about a quarter of the language recommendations published during these 15 months are coronavirus-related. The topics in the recommendations follow the development of the outbreak in Finland, showing how closely the language advisers work with the news organizations. Contrary to normal situations, the Finland-Swedish media language advisers could not fully rely on the language recommendations from Sweden, due to their different Covid-19 strategies. Instead, the norm authorities were experts in ministries and official institutions, illustrating how language planning is done collectively. The Finland-Swedish journalists rely heavily on the media language recommendations, showing a certain linguistic insecurity, which according to Muhr (2012) is typical for speakers of non-dominant varieties of a pluricentric language.