bluuebunny/crossref_metadata_2025 huggingface dataset:
Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo
Authors: Moniot Aurélie , Braux Julien , Bour Camille , Guillaume Christine , Lamret Fabien , Allart-Simon Ingrid , Audonnet Sandra , Renault Sarah , Rédini Francoise , Laronze-Cochard Marie , Sapi Janos , Gangloff Sophie C. , Gérard Stéphane , Velard Frédéric
Published: November 2021

Osteosarcoma is a rare primary bone cancer that mostly affects children and young adults. Current therapeutic approaches consist of combining surgery and chemotherapy but remain unfortunately insufficient to avoid relapse and metastases. Progress in terms of patient survival has remained the same for 30 years. In this study, novel pyridazinone derivatives have been evaluated as potential anti-osteosarcoma therapeutics because of their anti-type 4 phosphodiesterase activity, which modulates the survival of several other cancer cells. By using five—four human and one murine osteosarcoma—cell lines, we demonstrated differential cytotoxic effects of four pyridazinone scaffold-based compounds (mitochondrial activity and DNA quantification). Proapoptotic (annexin V positive cells and caspase-3 activity), anti-proliferative (EdU integration) and anti-migratory effects (scratch test assay) were also observed. Owing to their cytotoxic activity in in vitro conditions and their ability to limit tumor growth in a murine orthotopic osteosarcoma model, our data suggest that these pyridazinone derivatives might be hit-candidates to develop new therapeutic strategies against osteosarcoma.
Filtration Efficiency and Regeneration Behavior in a Catalytic Diesel Particulate Filter with the Use of Diesel/Polyoxymethylene Dimethyl Ether Mixture
Authors: Chen Hao , Su Xin , Wang Xiaochen , Sun Fengyu , Zhang Peng , Geng Liming , Wang Haifeng
Published: November 2021

Polyoxymethylene dimethyl ether (PODEn) is a promising diesel additive, especially in particulate matter reduction. However, how PODEn addition affects the filtration efficiency and regeneration process of a catalytic diesel particulate filter (cDPF) is still unknown. Therefore, this experimental work investigated the size-dependent particulate number removal efficiency under various engine loads and exhaust gas recirculation (EGR) ratios when fueling with diesel (D100) and diesel/PODEn mixture (P10). In addition, the regeneration behavior of the cDPF was studied by determining the breakeven temperatures (BETs) for both tested fuels. The results showed that the cDPF had lower removal efficiencies in nucleation mode particles but higher filtration efficiencies in accumulation mode particles. In addition, the overall filtration efficiency for P10 particles was higher than that for D100 particles. Positioning the upstream cDPF, increasing the EGR ratio slightly decreased the number concentration of nucleation mode particles but greatly increased that of accumulation mode particles. However, increasing the EGR ratio decreased the removal efficiency of nanoparticles, and this effect was more apparent for the P10 case. Under the same period of soot loading, the pressure drop of P10 fuel was significantly lower than that of diesel fuel. In addition, a significantly lower BET was observed for the P10 fuel, in comparison with D100 fuel. In conclusion, adopting cDPF is beneficial for fueling with P10 in terms of the overall filtration efficiency in the particulate number and the lower input energy requirement for active regeneration. However, with the addition of EGR, the lower filtration efficiencies of nanoparticles should be concerned, especially fueling with diesel/PODEn mixture.
Understanding the Surface Characteristics of Biochar and Its Catalytic Activity for the Hydrodeoxygenation of Guaiacol
Authors: Adilina Indri Badria , Widjaya Robert Ronal , Hidayati Luthfiana Nurul , Supriadi Edi , Safaat Muhammad , Oemry Ferensa , Restiawaty Elvi , Bindar Yazid , Parker Stewart F.
Published: November 2021

Biochar (BCR) was obtained from the pyrolysis of a palm-oil-empty fruit bunch at 773 K for 2 h and used as a catalyst for the hydrodeoxygenation (HDO) of guaiacol (GUA) as a bio-oil model compound. Brunauer–Emmet–Teller surface area analysis, NH3 and CO2-temperature-programmed desorption, scanning electron microscope–dispersive X-ray spectroscopy, CHN analysis and X-ray fluorescence spectroscopy suggested that macroporous and mesoporous structures were formed in BCR with a co-presence of hydrophilic and hydrophobic sites and acid–base behavior. A combination of infrared, Raman and inelastic neutron scattering (INS) was carried out to achieve a complete vibrational assignment of BCR. The CH–OH ratio in BCR is ~5, showing that the hydroxyl functional groups are a minority species. There was no evidence for any aromatic C–H stretch modes in the infrared, but they are clearly seen in the INS and are the majority species, with a ratio of sp3–CH:sp2–CH of 1:1.3. The hydrogen bound to sp2–C is largely present as isolated C–H bonds, rather than adjacent C–H bonds. The Raman spectrum shows the characteristic G band (ideal graphitic lattice) and three D bands (disordered graphitic lattice, amorphous carbon, and defective graphitic lattice) of sp2 carbons. Adsorbed water in BCR is present as disordered layers on the surface rather than trapped in voids in the material and could be removed easily by drying prior to catalysis. Catalytic testing demonstrated that BCR was able to catalyze the HDO of GUA, yielding phenol and cresols as the major products. Phenol was produced both from the direct demethoxylation of GUA, as well as through the demethylation pathway via the formation of catechol as the intermediate followed by deoxygenation.
Single-Layer MoS2-MoO3-x Heterojunction Nanosheets with Simultaneous Photoluminescence and Co-Photocatalytic Features
Authors: Saadati Maryam , Akhavan Omid , Fazli Hossein
Published: November 2021

Single-layer MoS2-MoO3-x heterojunction nanosheets with visible-light-sensitive band gap energy and average lateral dimensions of ~70 nm were synthesized by using a two-step combined exfoliation method. The exfoliation was initiated from pristine MoS2, while some sulfur sites in expanded MoS2 sheets during exfoliating were substituted by ambient non-thermal oxygen, resulting in formation of α-MoO3-x crystalline domains. The morphological features, crystalline structure, phase formation, number of layers, and optical properties of the MoS2-MoO3-x nanosheets were determined by atomic force microscopy; X-ray diffraction; field emission electron microscopy; transmission electron microscopy; and Raman, UV–visible–NIR, diffuse transmittance, and photoluminescence spectroscopies. The produced α-MoO3-x domains displayed a narrower indirect band gap energy (~1.95 eV) than that of stoichiometric MoO3 (~3 eV), and a broad light absorption range from visible to near-infrared region can act as a plasmonic material facilitating the separation of the photoinduced carriers and enhancing the photocatalytic activity of the MoS2 domain, having ~1.75(2.16) eV indirect (direct) band gap energy. In this regard, the MoS2-MoO3-x heterojunction nanosheets showed single-layer-based excitation-dependent luminescence emissions and visible-light-induced photocatalytic features, at the same time. This study can contribute to promising applications of sheet-like nanomaterials for purposes requiring simultaneous photoluminescence and photocatalytic features, such as in-vivo monitoring and targeting.
Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation
Authors: Yang Meng-Yin , Liu Bai-Shuan , Huang Hsiu-Yuan , Yang Yi-Chin , Chang Kai-Bo , Kuo Pei-Yeh , Deng You-Hao , Tang Cheng-Ming , Hsieh Hsien-Hsu , Hung Huey-Shan
Published: November 2021

Tissue repair engineering supported by nanoparticles and stem cells has been demonstrated as being an efficient strategy for promoting the healing potential during the regeneration of damaged tissues. In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul–Col, Pul–Au, Pul–Col–Au, and Col–Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments. The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis. The biocompatibility results demonstrated Pul–Col–Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation. Pul–Col–Au also induced the lowest cell apoptosis and facilitated the MMP activities. Moreover, we evaluated the efficacy of Pul–Col–Au in the enhancement of neuronal differentiation capacities for MSCs. Our animal models elucidated better biocompatibility, as well as the promotion of endothelialization after implanting Pul–Col–Au for a period of one month. The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
Neural Stem Cells: Promoting Axonal Regeneration and Spinal Cord Connectivity
Authors: de Freria Camila Marques , Van Niekerk Erna , Blesch Armin , Lu Paul
Published: November 2021

Spinal cord injury (SCI) leads to irreversible functional impairment caused by neuronal loss and the disruption of neuronal connections across the injury site. While several experimental strategies have been used to minimize tissue damage and to enhance axonal growth and regeneration, the corticospinal projection, which is the most important voluntary motor system in humans, remains largely refractory to regenerative therapeutic interventions. To date, one of the most promising pre-clinical therapeutic strategies has been neural stem cell (NSC) therapy for SCI. Over the last decade we have found that host axons regenerate into spinal NSC grafts placed into sites of SCI. These regenerating axons form synapses with the graft, and the graft in turn extends very large numbers of new axons from the injury site over long distances into the distal spinal cord. Here we discuss the pathophysiology of SCI that makes the spinal cord refractory to spontaneous regeneration, the most recent findings of neural stem cell therapy for SCI, how it has impacted motor systems including the corticospinal tract and the implications for sensory feedback.
Improving Cardiac Reprogramming for Heart Regeneration in Translational Medicine
Authors: Liu Liu , Guo Yijing , Li Zhaokai , Wang Zhong
Published: November 2021

Direct reprogramming of fibroblasts into CM-like cells has emerged as an attractive strategy to generate induced CMs (iCMs) in heart regeneration. However, low conversion rate, poor purity, and the lack of precise conversion of iCMs are still present as significant challenges. In this review, we summarize the recent development in understanding the molecular mechanisms of cardiac reprogramming with various strategies to achieve more efficient iCMs. reprogramming. Specifically, we focus on the identified critical roles of transcriptional regulation, epigenetic modification, signaling pathways from the cellular microenvironment, and cell cycling regulation in cardiac reprogramming. We also discuss the progress in delivery system optimization and cardiac reprogramming in human cells related to preclinical applications. We anticipate that this will translate cardiac reprogramming-based heart therapy into clinical applications. In addition to optimizing the cardiogenesis related transcriptional regulation and signaling pathways, an important strategy is to modulate the pathological microenvironment associated with heart injury, including inflammation, pro-fibrotic signaling pathways, and the mechanical properties of the damaged myocardium. We are optimistic that cardiac reprogramming will provide a powerful therapy in heart regenerative medicine.
MicroRNA Bta-miR-24-3p Suppressed Galectin-9 Expression through TLR4/NF-ĸB Signaling Pathway in LPS-Stimulated Bovine Endometrial Epithelial Cells
Authors: Oladejo Ayodele Olaolu , Li Yajuan , Shen Wenxiang , Imam Bereket Habte , Wu Xiaohu , Yang Jie , Ma Xiaoyu , Lv Yanan , Jiang Wei , Ding Xuezhi , Wang Shengyi , Yan Zuoting
Published: November 2021

Endometritis is a major infectious disease affecting dairy development. MicroRNAs are recognized as critical regulators of the innate immune response. However, the role and mechanism of Bta-miR-24-3p in the development of endometritis are still unclear. This study aimed to investigate the effect of Bta-miR-24-3p on the inflammatory response triggered by lipopolysaccharide (LPS) and to clarify the possible mechanism. LPS-treated bovine endometrial epithelial cells (BEECs) were cultured to investigate the role of Bta-miR-24-3p. The expression levels of Bta-miR-24-3p were downregulated, and galectin-9 (LGALS9) were measured by quantitative real-time polymerase chain reaction. The LPS-induced inflammatory response was assessed by the elevated secretion of inflammatory cytokines measured by using enzyme-linked immunosorbent assay and quantitative real-time polymerase chain reaction. Activation of nuclear factor-κB (NF-κB) and TLR4 pathway was assessed by Western blot. The interaction between Bta-miR-24-3p and LGALS9 was validated by bioinformatics analysis and a luciferase reporter assay. LPS-induction in BEECs with Bta-miR-24-3p was overexpressed leads inhibition of pro-inflammatory cytokines, LGALS9 expression, and TLR4/NF-ĸB pathway deactivation. Knockdown of LGALS9 inhibited the LPS-induced inflammatory response in BEECs. LGALS9 was validated as a target of Bta-miR-24-3p. Cloned overexpression of LGALS9 failed to alter the effect of Bta-miR-24-3p on the inflammatory response in BEECs. Overall, Bta-miR-24-3p attenuated the LPS-induced inflammatory response via targeting LGALS9. The immunotherapeutic stabilisation of Bta-miR-24-3p could give a therapeutic option for endometritis and other disorders commonly associated with endometritis, suggesting a novel avenue for endometritis treatment.
Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis
Authors: Sultan Muthanna , Wilson Kiesha , Abdulla Osama A. , Busbee Philip Brandon , Hall Alina , Carter Taylor , Singh Narendra , Chatterjee Saurabh , Nagarkatti Prakash , Nagarkatti Mitzi
Published: November 2021

Acute respiratory distress syndrome (ARDS) is a serious lung condition characterized by severe hypoxemia leading to limitations of oxygen needed for lung function. In this study, we investigated the effect of anandamide (AEA), an endogenous cannabinoid, on Staphylococcal enterotoxin B (SEB)-mediated ARDS in female mice. Single-cell RNA sequencing data showed that the lung epithelial cells from AEA-treated mice showed increased levels of antimicrobial peptides (AMPs) and tight junction proteins. MiSeq sequencing data on 16S RNA and LEfSe analysis demonstrated that SEB caused significant alterations in the microbiota, with increases in pathogenic bacteria in both the lungs and the gut, while treatment with AEA reversed this effect and induced beneficial bacteria. AEA treatment suppressed inflammation both in the lungs as well as gut-associated mesenteric lymph nodes (MLNs). AEA triggered several bacterial species that produced increased levels of short-chain fatty acids (SCFAs), including butyrate. Furthermore, administration of butyrate alone could attenuate SEB-mediated ARDS. Taken together, our data indicate that AEA treatment attenuates SEB-mediated ARDS by suppressing inflammation and preventing dysbiosis, both in the lungs and the gut, through the induction of AMPs, tight junction proteins, and SCFAs that stabilize the gut-lung microbial axis driving immune homeostasis.
Senescent Cells in Cancer: Wanted or Unwanted Citizens
Authors: Niklander Sven E. , Lambert Daniel W. , Hunter Keith D.
Published: November 2021

Over recent decades, the field of cellular senescence has attracted considerable attention due to its association with aging, the development of age-related diseases and cancer. Senescent cells are unable to proliferate, as the pathways responsible for initiating the cell cycle are irreversibly inhibited. Nevertheless, senescent cells accumulate in tissues and develop a pro-inflammatory secretome, known as the senescence-associated secretory phenotype (SASP), which can have serious deleterious effects if not properly regulated. There is increasing evidence suggesting senescent cells contribute to different stages of carcinogenesis in different anatomical sites, mainly due to the paracrine effects of the SASP. Thus, a new therapeutic field, known as senotherapeutics, has developed. In this review, we aim to discuss the molecular mechanisms underlying the senescence response and its relationship with cancer development, focusing on the link between senescence-related inflammation and cancer. We will also discuss different approaches to target senescent cells that might be of use for cancer treatment.
DUX4 Role in Normal Physiology and in FSHD Muscular Dystrophy
Authors: Mocciaro Emanuele , Runfola Valeria , Ghezzi Paola , Pannese Maria , Gabellini Davide
Published: November 2021

In the last decade, the sequence-specific transcription factor double homeobox 4 (DUX4) has gone from being an obscure entity to being a key factor in important physiological and pathological processes. We now know that expression of DUX4 is highly regulated and restricted to the early steps of embryonic development, where DUX4 is involved in transcriptional activation of the zygotic genome. While DUX4 is epigenetically silenced in most somatic tissues of healthy humans, its aberrant reactivation is associated with several diseases, including cancer, viral infection and facioscapulohumeral muscular dystrophy (FSHD). DUX4 is also translocated, giving rise to chimeric oncogenic proteins at the basis of sarcoma and leukemia forms. Hence, understanding how DUX4 is regulated and performs its activity could provide relevant information, not only to further our knowledge of human embryonic development regulation, but also to develop therapeutic approaches for the diseases associated with DUX4. Here, we summarize current knowledge on the cellular and molecular processes regulated by DUX4 with a special emphasis on FSHD muscular dystrophy.
Impact of the Main Cardiovascular Risk Factors on Plasma Extracellular Vesicles and Their Influence on the Heart’s Vulnerability to Ischemia-Reperfusion Injury
Authors: Majka Miłosz , Kleibert Marcin , Wojciechowska Małgorzata
Published: November 2021

The majority of cardiovascular deaths are associated with acute coronary syndrome, especially ST-elevation myocardial infarction. Therapeutic reperfusion alone can contribute up to 40 percent of total infarct size following coronary artery occlusion, which is called ischemia-reperfusion injury (IRI). Its size depends on many factors, including the main risk factors of cardiovascular mortality, such as age, sex, systolic blood pressure, smoking, and total cholesterol level as well as obesity, diabetes, and physical effort. Extracellular vesicles (EVs) are membrane-coated particles released by every type of cell, which can carry content that affects the functioning of other tissues. Their role is essential in the communication between healthy and dysfunctional cells. In this article, data on the variability of the content of EVs in patients with the most prevalent cardiovascular risk factors is presented, and their influence on IRI is discussed.
Paper-Based Vapor Detection of Formaldehyde: Colorimetric Sensing with High Sensitivity
Authors: Liao Chenglong , Zhang Miao , Gao Nan , Tian Qingyun , Shi Jiangfan , Chen Shuai , Wang Chuanyi , Zang Ling
Published: November 2021

We report on a novel colorimetric sensor system for highly sensitive detection of formaldehyde (FA) in the gas phase. The sensor is constructed with paper towel as a substrate coated with the sulfuric acid salt of hydroxylamine ((NH2OH)2·H2SO4) together with two pH indicators, bromophenol blue and thymol blue. Upon exposure to FA, the hydroxylamine will react with the absorbed FA to form a Schiff base (H2C=N-OH), thus releasing a stoichiometric amount of sulfuric acid, which in turn induces a color change of the pH indicator. Such a color change was significantly enriched by incorporating two pH indicators in the system. With the optimized molar ratio of the two pH indicators, the color change (from brown to yellow, and to red) could become so dramatic as to be visible to the eye depending on the concentration of FA. In particular, under 80 ppb of FA (the air quality threshold set by WHO) the color of the sensor substrate changes from brown to yellow, which can even be envisioned clearly by the naked eyes. By using a color reader, the observed color change can be measured quantitatively as a function of the vapor concentration of FA, which produces a linear relationship as fitted with the data points. This helps estimate the limit of detection (LOD), to be 10 ppb under an exposure time of 10 min, which is much lower than the air quality threshold set by WHO. The reported sensor also demonstrates high selectivity towards FA with no color change observed when exposed to other common chemicals, including solvents and volatile organic compounds. With its high sensitivity and selectivity, the proposed paper-based colorimetric sensor thus developed can potentially be employed as a low-cost and disposable detection kit that may find broad application in detecting FA in indoor air and many other environments.
Emotion Dysregulation as a Mediator of the Relationship between Anxiety, Compulsive Exercise and Eating Disorder Symptoms in Adolescents
Authors: Cuesta-Zamora Cristina , González-Martí Irene , García-López Luis Miguel , Ros Laura , Plateau Carolyn R. , Ricarte Jorge Javier
Published: November 2021

Anxiety has been suggested to be a key contributing factor for compulsive exercise, however, existing literature has demonstrated contradictory relationships between anxiety and compulsive exercise among adolescents. According to the Emotional Cascade Model (ECM), factors such as rumination and emotional suppression may mediate the association between affect and exercise. The current study therefore aimed to investigate whether rumination and emotional suppression mediate the relationship between anxiety and compulsive exercise in predicting ED symptoms in adolescents. Questionnaires assessing compulsive exercise, anxiety, depressive rumination, emotional suppression, and ED symptoms were completed by 212 adolescent males (Mage = 13.39, SD = 1.22) and 189 adolescent females (Mage = 13.64, SD = 1.29). The structural equation model showed indirect effects between anxiety and compulsive exercise through rumination and emotional suppression in males but not in females. Moreover, anxiety had an indirect effect on eating disorder symptoms through rumination, emotional suppression and compulsive exercise in both males and females. In line with ECM, the results suggest that rumination and emotional suppression may have a key role in the association between anxiety, compulsive exercise and eating disorder symptoms in adolescents. These findings suggest that compulsive exercise may be used as a dysfunctional coping mechanism to escape from a negative emotional cascade generated by the interaction of anxiety, rumination and emotional suppression. Future longitudinal studies to test the role of compulsive exercise as a dysfunctional behaviour in the ECM are needed.
Microstructure and Mechanical Properties of Carbide Reinforced TiC-Based Ultra-High Temperature Ceramics: A Review
Authors: Mao Haobo , Shen Fuqiang , Zhang Yingyi , Wang Jie , Cui Kunkun , Wang Hong , Lv Tao , Fu Tao , Tan Tianbiao
Published: November 2021

TiC ceramics have become one of the most potential ultra-high temperature structural materials, because of its high melting point, low density, and low price. However, the poor mechanical properties seriously limit its development and application. In this work, this review follows PRISMA standards, the mechanism of the second phase (particles, whiskers, and carbon nanotubes) reinforced TiC ceramics was reviewed. In addition, the effects of the second phase on the microstructure, phase composition and mechanical properties of TiC ceramics were systematically studied. The addition of carbon black effectively eliminates the residual TiO2 in the matrix, and the bending strength of the matrix is effectively improved by the strengthening bond formed between TiC; SiC particles effectively inhibit the grain growth through pinning, the obvious crack deflection phenomenon is found in the micrograph; The smaller grain size of WC plays a dispersion strengthening role in the matrix and makes the matrix uniformly refined, and the addition of WC forms (Ti, W) C solid solution, WC has a solid solution strengthening effect on the matrix; SiC whiskers effectively improve the fracture toughness of the matrix through bridging and pulling out, the microscopic diagram and mechanism diagram of SiC whisker action process are shown in this paper. The effect of new material carbon nanotubes on the matrix is also discussed; the bridging effect of CNTs can effectively improve the strength of the matrix, during sintering, some CNTs were partially expanded into GNR, in the process of crack bridging and propagation, more fracture energy is consumed by flake GNR. Finally, the existing problems of TiC-based composites are pointed out, and the future development direction is prospected.
Synergetic Design of Transparent Topcoats on ITO-Coated Plastic Substrate to Boost Surface Erosion Performance
Authors: Zhang Xuan , Chen Yuandong , Zhang Wenqiao , Zhong Yanli , Lei Pei , Hao Changshan , Yan Yue
Published: November 2021

Transparent conductive films (TCFs) have received much research attention in the area of aeronautical canopies. However, bad wear, corrosion resistance and weak erosion performance of TCFs dramatically limit their scalable application in the next-generation aeronautical and optoelectronic devices. To address these drawbacks, three types of optically transparent coatings, including acrylic, silicone and polyurethane (PU) coatings were developed and comparatively investigated ex situ in terms of Taber abrasion, nanoindentation and sand erosion tests to improve the wear-resistance and sand erosion abilities of ITO-coated PMMA substrates. To elucidate the sand erosion failure of the coatings, the nanoindentation technique was employed for quantitative assessment of the shape recovery abilities under probe indentation. Results show that the PU topcoats can greatly enhance the sand erosion properties, which were superior to those of acrylic and silicone topcoats. This result can be attributed to the good toughness and self-healing properties of PU topcoats. Additionally, high hardness and good Taber abrasion properties of the ITO films and silicone topcoats did not have an obvious or affirmatory effect on the sand erosion abilities, based on their brittleness and irreparable properties under sand erosion.
Synergic Effect of Microorganism and Colloidal Biochar-Based Organic Fertilizer on the Growth and Fruit Quality of Tomato
Authors: Gu Shiguo , Lian Fei , Yang Hanyue , Han Yaru , Zhang Wei , Yang Fan , Gao Jie
Published: November 2021

It is well known that carbon-based organic fertilizer can effectively promote crop growth and improve nutrient utilization efficiency. However, little is known about the effect of microorganisms on the nutrient availability of carbon-based organic fertilizer. To elucidate the contribution of microorganisms to the agricultural benefit of colloidal biochar-based fertilizer, a 5-month pot experiment was conducted to study the effect of different combinations of Methyltrophic bacillus, colloidal biochar, and organic fertilizer on physical–chemical properties of soil, plant growth, physiological-biochemical reactions, yield, and quality of tomato. The results show that the addition of Methyltrophic bacillus effectively promoted the availability of soil nutrients (such as nitrate nitrogen and available potassium) and increased soil cation exchange capacity; meanwhile, it significantly increased the content of chlorophyll-a (9.42–27.41%) and promoted the net photosynthetic rate (10.86–13.73%) and biomass of tomato fruit (17.84–26.33%). The contents of lycopene, vitamin C, total sugar, and soluble sugar in the fruits treated by the ternary combination of Methyltrophic bacillus, colloidal biochar, and organic fertilizer increased by 58.40%, 46.53%, 29.45%, and 26.65%, respectively. The above results demonstrate that the addition of beneficial microorganisms could further improve the performance of biochar-based fertilizer on plant growth, yield, and fruit quality of tomato. This information provides evidence for the promising performance of microorganism-supported biochar organic fertilizer in agricultural applications.
Defect Formation Mechanism and Performance Study of Laser Cladding Ni/Mo Composite Coating
Authors: Sun Min , Pang Ming
Published: November 2021

In order to improve the wear resistance of Cu, a Ni/Mo composite coating was applied on the surface of Cu alloy by means of laser cladding. The laser power was 6000 W, the scanning speed was 5 mm/s and the feed rate was 10 g/min. The transition layer of the Ni layer had three layers, and the surface layer of the Mo layer had two layers. The results showed that the surface of the cladding layer was pure Mo. Due to the fluidity and non-equilibrium solidification of Mo in the molten state, pores and cracks along the grain boundary were observed in the Mo layer. The results showed that the cross-section of cladding layer was divided into a pure Mo layer, Mo-Ni-Cu mixed layer and an Ni-Cu mixed layer. The surface hardness of the Mo layer was 200~460 HV. Ni3Mo was formed at the interface of Mo and Ni. The hardness was improved by Ni3Mo; the maximum hardness was 750 HV. Under the same load and wear time, the wear rate of Cu was three times that of the surface layer.
Hybrid ZnO Flowers-Rods Nanostructure for Improved Photodetection Compared to Standalone Flowers and Rods
Authors: Al-Enizi Abdullah M. , Shaikh Shoyebmohamad F. , Tamboli Asiya M. , Marium Afifa , Ijaz Muhammad Fazal , Ubaidullah Mohd , Moydeen Abdulhameed Meera , Ekar Satish U.
Published: November 2021

Different Zinc Oxide (ZnO) morphologies have been used to improve photodetector efficiencies for optoelectronic applications. Herein, we present the very novel hybrid ZnO flower-rod (HZFR) morphology, to improve photodetector response and efficiency when compared to the prevalently used ZnO nanorods (NRs) and ZnO nanoflowers (NFs). The HZFR was fabricated via sol-gel microwave-assisted hydrothermal methods. HZFR achieves the benefits of both NFs, by trapping a greater amount of UV light for the generation of e-h pairs, and NRs, by effectively transporting the generated e-h pairs to the channel. The fabricated photosensors were characterized with scanning electron microscopy, X-ray diffraction, photoluminescence, and a Keithley 4200A-SCS parameter analyzer for their morphology, structural characteristics, optical performance, and electrical characteristics, respectively. The transient current response, current-voltage characteristics, and responsivity measurements were set as a benchmark of success to compare the sensor response of the three different morphologies. It was found that the novel HZFR showed the best UV sensor performance with the fastest response time (~7 s), the highest on-off ratio (52), and the best responsivity (126 A/W) when compared to the NRs and NFs. Hence, it was inferred that the HZFR morphology would be a great addition to the ZnO family for photodetector applications.
Impact of a Transparent Coating on the Reflectance of a Line Halftone Pattern
Authors: Dailliez Fanny , Hébert Mathieu , Blayo Anne , Chagas Lionel , Fournel Thierry
Published: November 2021

Many prints are coated to increase their resistance or to enhance their appearance. Applying a smooth transparent layer on a print darkens and saturates its color, an easily observable effect which can be predicted in order to obtain better color management of coated surfaces and ink saving. A model was thus developed which describes the reflectance of a single-ink line halftone in optical contact with a transparent smooth coating. It is based on the peculiar way light diffuses inside the coating layer, a phenomenon called the “halo effect”. The model was compared to two experiments conducted at different scales where line halftones were coated with different coating thicknesses. The experiments enabled us to identify and measure the darkening effect caused by a coating layer, and validated the model.
Survey of Mura Defect Detection in Liquid Crystal Displays Based on Machine Vision
Authors: Ming Wuyi , Zhang Shengfei , Liu Xuewen , Liu Kun , Yuan Jie , Xie Zhuobin , Sun Peiyan , Guo Xudong
Published: November 2021

Liquid crystal display (LCD) is a display device based on liquid crystal electro-optic effect, and LCDs have gradually appeared and have become an indispensable part of people’s lives. In the development of LCD technology, the detection of Mura defects is a key concern in the manufacturing process. The Mura defect is a kind of display defect with low contrast and an irregular shape. This study first explains the mechanism of Mura defects in the LCD manufacturing process and classifies typical Mura defects. Then, three main purposes for the defect detection of LCDs are compared, and the advantages and disadvantages are conducted. Following that, this research examines reviews the linked literature on image preprocessing, feature extraction, dimension reduction, and classifiers of Mura defects. Finally, the future development trend and research direction of Mura defect detection based on machine vision can be drawn by this study.
Study and Analysis of Simple and Precise of Contact Resistance Single-Transistor Extracting Method for Accurate Analytical Modeling of OTFTs Current-Voltage Characteristics: Application to Different Organic Semiconductors
Authors: Alghamdi Noweir Ahmad
Published: November 2021

Contact resistance (Rc) characterizes the interface of source-drain electrodes/organic semiconductors and controls the injection efficiency of carriers in organic thin-film transistors (OTFTs). This research paper presents and assesses two methods for extracting the value of the contact resistance from the measured current-voltage characteristics of OTFTs made with various p-type organic semiconductors as active layers. These two methods are the transition voltage method (TVM) and the transfer line method (TLM). The obtained Rc values by the TVM method are in fair agreement with those obtained by TLM, with a maximum percentage of difference around 10%, demonstrating the accuracy of the used transition-voltage method. An analytical model was employed to calculate output characteristics in the linear regime of OTFTs made with various organic semiconductors using the contact resistance values obtained by the transition voltage method. The calculated results are in reasonably good agreement with the experimental ones of each fabricated device, which affirms the ability of the used model to characterize the charge transport correctly in these types of devices. It can be concluded that the used TVM method is not only an easy and practical method, but also a precise way for extracting Rc in OTFTs produced using different organic semiconductor materials.
A Study on Fabrication Process of Gold Microdisk Arrays by the Direct Imprinting Method Using a PET Film Mold
Authors: Potejanasak Potejana
Published: November 2021

In this study, an efficient nanofabrication process of metal microdisk arrays using direct imprinting was developed. This process was comprised of three steps; sputter etching on the quartz glass substrate, gold thin film deposition on an etched surface of a substrate, and transfer imprinting using a polyethylene terephthalate (PET) film mold on the Au thin film. A new idea to utilize a PET film mold for disk patterning by the nano transfer imprinting was examined. The PET film mold was prepared by thermally embossing the pillar pattern of a master mold on the PET film. The master mold was prepared from a silicon wafer. The PET film mold was used for transfer imprinting on a metal film deposited on a quartz substrate. The experimental results revealed that the PET film mold can effectively form gold micro-disk arrays on the Au film despite the PET film mold being softer than the Au film. This method can control the distribution and orientation of the nano-arrays on the disk. The plasmonic properties of the gold micro-disk arrays are studied and the absorbance spectrum exhibit depends on the distribution and orientation of gold micro-disk patterns. The nano-transfer imprinting technique is useful for fabricating metallic microdisk arrays on substrate as a plasmonic device.
Thermoplastic Extrusion Additive Manufacturing of High-Performance Carbon Fiber PEEK Lattices
Authors: Santiago Carolyn Carradero , Yelamanchi Bharat , Diosdado De la Peña Jose Angel , Lamb Jeffrey , Roguski Krzysztof , Turzyński Filip , Faruqui Ron , Choo Kyosung , Du Plessis Anton , Sillani Francesco , MacDonald Eric , Cortes Pedro
Published: November 2021

Polyetheretherketone (PEEK) has been the focus of substantial additive manufacturing research for two principal reasons: (a) the mechanical performance approaches that of aluminum at relatively high temperatures for thermoplastics and (b) the potential for qualification in both the aerospace and biomedical industries. Although PEEK provides outstanding strength and thermal stability, printing can be difficult due to the high melting point. Recently, high-temperature soluble support has enabled the printing of lattices and stochastic foams with overhanging features in these high-performance carbon fiber thermoplastics, in which density can be optimized to strike a balance between weight and strength to enhance performance in applications such as custom implants or aerospace structures. Although polymer powder bed fusion has long been capable of the combination of these geometries and materials, material extrusion with high-temperature sacrificial support is dramatically less expensive. This research provides a comprehensive mechanical analysis and CT-scan-based dimensional study of carbon fiber PEEK lattice structures enabled with high-temperature support and including model validation.
Effect of Curing Conditions on the Strength Development of Alkali-Activated Mortar
Authors: Kong Lijuan , Fan Zirui , Ma Wenchen , Lu Jiatao , Liu Yazhou
Published: November 2021

In this study, the strength development and microstructure evolution of alkali-activated fly ash (AAF), granulated blast furnace slag (AAG), and metakaolin (AAM) mortars under standard curing, steam curing, and oven curing conditions were investigated. The results show that 80 °C steam curing was more suitable for AAF mortar. Although oven curing was not as good as steam curing under the same temperature, the water evaporation increased the volume density of the N-A-S-H gel and refined the pore structure. For AAG mortar, the strength developed according to a Boltzmann function with time under steam curing conditions, which increased rapidly in the first 8 h, but grew little after about 15 h. Moreover, the strength development was severely limited by steam curing at 60 °C, and decreased under oven curing conditions due to the formation of microcracks that were induced by temperature stress and chemical shrinkage. For AAM mortar, the strength developed according to an Allometric power function with time under steam curing conditions, and the N-A-S-H gel formed in AAM had a higher polymerization degree and denser structure compared to that in AAF. The compressive strength of AAM mortar was 31.7 MPa after 80 °C steam curing for 4 h, and the standard curing time required to reach the same strength was less than 24 h, indicating that the standard curing was more suitable.
Modeling and Simulation of Hafnium Oxide RRAM Based on Oxygen Vacancy Conduction
Authors: Lin Jinfu , Liu Hongxia , Wang Shulong , Zhang Siyu
Published: November 2021

The resistive memory has become one of the most promising new memory types because of its excellent performance, and HfO2 resistive material has attracted extensive attention. The conduction mechanism based on oxygen vacancy is widely recognized in the research of new nonvolatile memory. An RRAM electrothermal coupling model based on the oxygen vacancy conduction mechanism was constructed using COMSOL. The resistance process of the device is simulated by solving the coefficient partial differential equation, and the distribution of oxygen vacancy concentration, temperature, electric field, electric potential and other parameters in the dielectric layer at different voltages are obtained. The effects of temperature, dielectric layer thickness, top electrode thermal conductivity and conductive wire size on the resistance characteristics of the device are studied. It has guiding significance to further study the RRAM mechanism.
Numerical Modeling of High Conversion Efficiency FTO/ZnO/CdS/CZTS/MO Thin Film-Based Solar Cells: Using SCAPS-1D Software
Authors: Zyoud Samer H. , Zyoud Ahed H. , Ahmed Naser M. , Prasad Anupama R. , Khan Sohaib Naseem , Abdelkader Atef F. I. , Shahwan Moyad
Published: November 2021

The numerical modeling of a copper zinc tin sulfide (CZTS)-based kesterite solar cell is described in detail in this article. To model FTO/ZnO/CdS/CZTS/MO structured solar cells, the Solar Cell Capacitance Simulator-one-dimension (SCAPS-1D) program was utilized. Numerical modeling was used to estimate and assess the parameters of various photovoltaic thin film solar cells. The impact of different parameters on solar cell performance and conversion efficiency were explored. Because the response of a solar cell is partly determined by its internal physical mechanism, J-V characteristic characteristics are insufficient to define a device’s behavior. Regardless of the conviction in solar cell modeling, variable attributes as well as many probable conditions must be handled for simulation. Promising optimized results were obtained with a conversion efficiency of (η% = 25.72%), a fill factor of (FF% = 83.75%), a short-circuit current of (JSC  = 32.96436 mA/cm2), and an open-circuit voltage of (VOC = 0.64 V). The findings will aid in determining the feasibility of manufacturing high-efficiency CZTS-based solar cells. First, in the SCAPS-1D environment, the impacts of experimentally constructed CZTS solar cells were simulated. The experimental data was then compared to the simulated results from SCAPS-1D. After optimizing cell parameters, the conversion efficiency of the improved system was observed to rise. The influence of system factors, such as the thickness, acceptor, and donor carrier concentration densities of the absorber and electron transport layers, and the effect of temperature on the efficiency of CZTS-based photovoltaic cells, was explored using one-dimensional SCAPS-1D software. The suggested findings will be extremely useful to engineers and researchers in determining the best method for maximizing solar cell efficiency, as well as in the development of more efficient CZTS-based solar cells.
Study on Micro-Structure and Tensile Mechanical Properties of Dissimilar Metal Weld Joint Connecting Steam Generator Nozzle and Safe-End
Authors: Qi Shuang , Xiang Wenxin , Cai Lixun , Liu Xiaokun , Wang Yonggang , Ning Fangmao , Qi Lei , Yu Weiwei , Shi Jinhua
Published: November 2021

The safe-end of a steam generator (SG) nozzle dissimilar metal weld (DMW) for pressurized water reactors (PWRs) is the weakest point of failure which is crucial for the safe operation of a nuclear power station. Related to materials micro-structures, a uniaxial stress–strain relationship is the basic input parameter for nuclear power plant design, safety evaluation, and life management. In this paper, the micro-structure and tensile mechanical properties of a DMW of a European pressurized water reactor (EPR) were studied. Vickers hardness tester, optical microscope, and electron back scatter diffraction were used to analyze the micro-structure of the DMW joint. In addition, the residual strain of the DMW joint base material, heat-affected zone, weld metal, and fusion boundary region were studied. Based on digital image correlation (DIC) technology, tensile mechanical properties of the DMW joint were obtained. The results show that an accurate tensile stress–strain relationship of dissimilar metal welded joints can be obtained by using the DIC technique, the weld is the relatively weak link, and the residual strain is concentrated in the heat-affected zone. This study provides valuable engineering information regarding nuclear power plant design, in-service performance testing, and structural analysis and evaluation of welds containing defects.
Contact-Mediated Nucleation of Subcooled Droplets in Melt Emulsions: A Microfluidic Approach
Authors: Kaysan Gina , Rica Alexander , Guthausen Gisela , Kind Matthias
Published: November 2021

The production of melt emulsions is mainly influenced by the crystallization step, as every single droplet needs to crystallize to obtain a stable product with a long shelf life. However, the crystallization of dispersed droplets requires high subcooling, resulting in a time, energy and cost intensive production processes. Contact-mediated nucleation (CMN) may be used to intensify the nucleation process, enabling crystallization at higher temperatures. It describes the successful inoculation of a subcooled liquid droplet by a crystalline particle. Surfactants are added to emulsions/suspensions for their stabilization against coalescence or aggregation. They cover the interface, lower the specific interfacial energy and form micelles in the continuous phase. It may be assumed that micelles and high concentrations of surfactant monomers in the continuous phase delay or even hinder CMN as the two reaction partners cannot get in touch. Experiments were carried out in a microfluidic chip, allowing for the controlled contact between a single subcooled liquid droplet and a single crystallized droplet. We were able to demonstrate the impact of the surfactant concentration on the CMN. Following an increase in the aqueous micelle concentrations, the time needed to inoculate the liquid droplet increased or CMN was prevented entirely.
The Principle of Maximal Simplicity for Modular Inorganic Crystal Structures
Authors: Krivovichev Sergey V.
Published: November 2021

Modularity is an important construction principle of many inorganic crystal structures that has been used for the analysis of structural relations, classification, structure description and structure prediction. The principle of maximal simplicity for modular inorganic crystal structures can be formulated as follows: in a modular series of inorganic crystal structures, the most common and abundant in nature and experiments are those arrangements that possess maximal simplicity and minimal structural information. The latter can be quantitatively estimated using information-based structural complexity parameters. The principle is applied for the modular series based upon 0D (lovozerite family), 1D (biopyriboles) and 2D (spinelloids and kurchatovite family) modules. This principle is empirical and is valid for those cases only, where there are no factors that may lead to the destabilization of simplest structural arrangements. The physical basis of the principle is in the relations between structural complexity and configurational entropy sensu stricto (which should be distinguished from the entropy of mixing). It can also be seen as an analogy of the principle of least action in physics.