bluuebunny/crossref_metadata_2025 huggingface dataset:
A Causal Framework for Cross-Cultural Generalizability
Authors: Deffner Dominik , Rohrer Julia M. , McElreath Richard
Published: September 2021

Behavioral researchers increasingly recognize the need for more diverse samples that capture the breadth of human experience. Current attempts to establish generalizability across populations focus on threats to validity, constraints on generalization and the accumulation of large cross-cultural datasets. But for continued progress, we also require a framework that lets us determine which inferences can be drawn and how to make informative cross-cultural comparisons. We describe a generative causal modeling framework and outline simple graphical criteria to derive analytic strategies and implied generalizations. Using both simulated and real data, we demonstrate how to project and compare estimates across populations. We conclude with a discussion of how a formal framework for generalizability can assist researchers in designing more informative cross-cultural studies and thus provides a more solid foundation for cumulative and generalizable behavioral research.
Phytochemical Properties and In-vitro Antimicrobial Potency of Wild Edible Mushrooms (Pleurotus ostreatus) obtained from Yenagoa, Nigeria
Authors: Ogidi Odangowei Inetiminebi , Oguoma Lilian Maureen Oluchi , Adigwe Patrick Chukwudi , Anthony Blessing Bumein
Published: September 2021

Microorganism resistance to synthetic antibiotics is an increasing public health challenge, therefore, new antimicrobial agents from different plant and biological sources are sought-after. This research was aimed at evaluating the phytochemical properties and antimicrobial potency of wild edible mushrooms. Qualitative and quantitative phytochemical analysis was done using the standard method of Association of Official Analytical Chemist and agar well diffusion method was used for antimicrobial analysis. Phytochemical results of wild edible mushroom Pleurotus ostreatus obtained from Yenagoa, shows varying quantities of tannins, terpenoids, alkaloids, flavonoids, saponins, glycosides and steroids. The methanol and aqueous extracts of the samples reveals different degree of inhibition on both bacteria and fungi (Shigella sp., Staphylococcus sp., Vibrio sp., Escherichia coli, Penicillium sp., Yeast and Moulds). Aqueous extracts were more effective on the test organisms when compared to methanol extracts. P. ostreatus showed good antimicrobial potency against all the microorganisms tested. The findings from this study show the efficacy of wild edible mushroom as a potent antimicrobial agent.
A mini review on Calotropis procera and tapping its phytochemical and pharmacological potential
Authors: Kundu Satyabrata
Published: September 2021

Calotropis procera is considered as a medicinal plant belonging to the Asclepiadaceae family, surrounded throughout India and in other tropical areas. The common names of C. procera are Arka, Akanal, Madar, and Akanda. Based on the morphological characteristics, the leaves of C. procera is characterized as ovate, obovate, ovate-oblong or elliptical. The medicinal value or pharmacological properties of this plant are associated with its latex. C. procera leaves is said to be important antidote against snake bite, burning, rheumatism, mumps and bacterial infections. The phytochemical composition of leaf powder composed of cardenolides, steroids, tannins, glycosides, terpenoids, flavonoids, alkaloids and saponins. Phytochemical screening of bark also showed the presence of several secondary metabolites. Latex mainly contains calotropaine (cardiotoxic), a proteolytic enzyme and also contains a small percentage of nontoxic proteolytic enzyme, calotropin. The plant has several ecological importance including natural phytoremediation, improvement in soil quality. Mainly, C. procera has great importance throughout world for its great value.
The Effect of Grape Seed Extract Supplementation on Delayed Onset Muscle Soreness (DOMS) in Young Healthy Female Students
Authors:   Department of Physical Education, University of Mohaghegh-Ardabili, Ardabil, Iran, Sadati Jilla Raees- , Roohi Babak Nakhostin- ,   Department of Physical Education & Sports Science, Ardabil Branch, Islamic Azad University, Ardabil, Iran, Siahkouhian Marefat ,   Department of Physical Education & Sports Science, Ardabil Branch, Islamic Azad University, Ardabil, Iran
Published: September 2021

Background: Delayed onset muscle soreness (DOMS) is a common experience after unusual activities particularly eccentric exercises. The aim of the present study was to investigate the effect of grape seed extract (GSE) on some factors of DOMS on non-athletic female students. Method: Twenty young healthy female students were randomly allocated into two experimental (GSE=10n) and placebo (PLC=10n) groups. T produce DOMS, a forty-five repetition of eccentric elbow curl in three sets was performed. Venous blood samples were obtained before and after supplementation, immediately, 24h, and 48h after exercise for analysis of creatine kinase (CK), lactate dehydrogenase (LDH). The pain was assessed by visual analogue scale (VAS). Results: There was a significant increase in CK activity after exercise compared with before exercise in both groups (P<0.05)‚ but no significant differences between two groups at any time (P>0.05). Furthermore, The VAS scores were significantly lower in GSE compared with PLC group 24h and 48h after exercise (P<0.05). Conclusion: Although GSE supplementation has not been able to affect the CK and LDH activity, it seems that its anti-inflammatory or analgesic effects have been reduced the pain caused by DOMS.
The Perception of the Teachers Towards Virtual Class and Obstacles During Covid-19 Lockdown Phase
Authors: Rai Uttam Sing , Basnet Hom Bahadur
Published: September 2021

Virtual class uses computer software and internet to deliver instruction to the students. This eliminates needs for teachers and students to share the physical classroom. Virtual learning is an emerging educational paradigm which is transforming the way students learn. However, this virgin field of research has not been studied rigorously in the context of Nepal. Considering this, the research was carried out to identify the perception of the teacher of Bhojpur Multiple Campus towards virtual class during COVID-19 lockdown phase. The research adopted quantitative design which is based on the teachers who were involved in virtual teaching during COVID-19 lockdown phase. The study applied non-random purposive sampling process to select the sample for gathering data. The researcher found out that the teachers had the positive perception towards virtual class as 68% teachers agreed with the statement that virtual class is suitable solution during COVID-19 lockdown phase because it saves time and effort. The study may contribute to the educators and the teachers who are thinking to formulate policy for applying virtual class during luck down phase when pandemic is overwhelmed across the country like COVID-19.
Periferija i margina – značenja i konteksti
Authors: Pycia-Košćak Paulina
Published: September 2021

The article explores semantics and the use of two lexemes: periphery and margin. Both lexemes in dictionaries are explicitly or implicitly defined in opposition to the center and denote the surface, the area, the space that is away from it, which is ‘outside’. The first part analyzes their definitions in Croatian language dictionaries, primary and secondary meanings and similarities and differences in meanings. The second part covers the study of contexts in which they have been recorded and the correspondence of lexical meaning with a specified situation. The analyzed lexemes have similar range of meaning, so the article also questions their possible substitutability. Both lexemes are of foreign origin and in the original languages they refer to neutral categories, they have a denotative meaning. However, in the Croatian language, they also have a secondary, marked meaning, therefore the research takes into account (in)direct evaluation that indicates how these lexemes work in the mind of language user. The searching covers the problem of their marking and tries to answer the question whether they are always stigmatized as a negative sign of concepts that indicate what Croatian phrases can suggest (for example to be on / at the periphery of something, to be on the margins) or they can also be relied to positive features and affirm certain phenomena. The analysis is carried out on examples from the Croatian Language Corpus and the Croatian National Corpus, which allowed an overview of different types of discourses and texts.
Hrvatski jezik u Bosni i Hercegovini – život na rubu (egzistencija i perspektive)
Authors: Baković Matijas
Published: September 2021

The paper will consider the position of the Croatian language in Bosnia and Herzegovina and attempt to answer the question whether Croats living in Bosnia and Herzegovina should be using Standard Croatian as prescribed by the authorities in Zagreb or if they should insist upon their own peculiarities resulting from specific social and political circumstances as well as a hundred years of separation from the homeland. What position should be taken with regards to numerous words of Turkish, Arabic and Persian origin making up the vocabulary of Croats living in Bosnia and Herzegovina, considering the wide variety of words of German, Italian and Hungarian origin characteristic of the language spoken in different parts of Croatia? There are those who believe that the Croatian language in Bosnia and Herzegovina should and must be separate in some of its language solutions from the Croatian language as standardised by the authorities in Zagreb. They subscribe to the view that the Croatian language in Bosnia and Herzegovina, as well as the Croats themselves, are systematically neglected by the homeland, being used only for political point-scoring. On the other hand, the University of Mostar is the only university in Bosnia and Herzegovina teaching in the Croatian language as prescribed by the authorities in Croatia, invoking the unity of the Croatian people and language used by all Croats, regardless of their country of residence. The paper will try and clarify which position is the correct one, whether there can be only one correct position or the solution for Croats in Bosnia and Herzegovina lies in a different direction.
Labin ili izvedba undergrounda kao jedan od modusa otpora izolaciji/periferiji
Authors: Marjanić Suzana
Published: September 2021

Using the example of the town of Labin in Istria, I demonstrate how isolation, the so-called periphery, can also serve as an expression of resistance in a cultural niche. The collective Labin Art Express (L.A.E., initiated by Dean Zahtila, late Krešimir Farkaš, Graziano Kršić) is the initiator of the fundamental L.A.E. project Underground City XXI ‒ independent underground Labin cultural city as an alternative to the existing above-ground, heteronomous Labin, i.e. the creation of a real city 150 m below the earth’s surface ‒ in underground halls and tunnels, carved in solid rock, connecting Labin, Raša, Plomin and Rabac, with streets, bars, galleries, swimming pools, playgrounds for children, shops, restaurants, the Museum of Mining and Industry of Istria. Thereby we can compare Labin in terms of urbanity and anthropology with the town of Katowice, which in 2018 was selected to host the most significant UN Climate Change Conference, following the 2015 Paris Agreement. Katowice were chosen as one of Europe’s most polluted sites due to the exploitation of coal i.e. the transition of the aforementioned town from a mining and industrial site to a modern industrial, economical, technological and cultural centre.
Atlantoaxial Rotary Subluxation in Marfan Syndrome
Authors: Wei John Ong Ying , Chan Tin , Lo William , Wimalachandra Buddhika
Published: September 2021

Atlantoaxial rotary subluxation (AARS) is a rare condition that may cause persistent torticollis if not treated appropriately. AARS is associated with ligamentous abnormalities, which may result from acquired or congenital disorders. We report the case of a paediatric patient with congenital Marfan syndrome and AARS due to a minor traumatic head injury. A 9-year-old boy with a known diagnosis of Marfan syndrome (and extensive family history) encountered a traumatic head injury that presented as torticollis with a typical “cock-robin” head and neck orientation. AARS was diagnosed through a head and neck CT scan. He underwent initial conservative treatment involving a muscle relaxant (diazepam) and Miami-J collar. This was followed up with manipulation under anaesthesia (MUA) and further cervical traction, which resolved the subluxation without more invasive treatment. To the best of our knowledge, AARS associated with Marfan syndrome has been rarely reported in literature. It is postulated that the ligamentous laxity associated with Marfan syndrome would increase the patient’s predisposition to AARS and more importantly, the propensity to require more invasive treatment (internal fixation). However, our patient unexpectedly responded well to conservative management, namely MUA and cervical traction. This illustrates that despite the increased ligamentous laxity in Marfan syndrome, it is still advisable to conservatively manage AARS before deciding to perform invasive internal fixation.International Journal of Human and Health Sciences Supplementary Issue-2: 2021 Page: S15
A Healthy Young Lady with ‘Unprovoked’ Persistent Bilateral Pulmonary Embolism - Why?
Authors: Bin Mohd Fauad Muhammad Farid , Baharuddin Hazlyna , Mohd Zim Mohd Arif , Johari Bushra
Published: September 2021

Pulmonary embolism (PE) was reported in about 9% patients with antiphospholipid syndrome (APS). Seronegative APS is an entity which demonstrates clinical manifestations highly suggestive of APS but persistently negative APS antibodies. A 31-year-old lady presented with a two-month history of exertional dyspnoea. She had two consecutive miscarriages at 12 and 14 weeks, previously. Physical examination revealed a thin lady who was tachycardic, tachypneic, hypoxic but normotensive. There was a loud P2 without signs of heart failure. Investigations revealed a type 1 respiratory failure, sinus tachycardia with right ventricular strain pattern, cardiomegaly with normal lung fields, and dilated right atrium and right ventricle with increased in pulmonary arterial pressure of 70mmHg from echocardiography. CT pulmonary angiography (CTPA) confirmed the presence of PE over bilateral pulmonary arteries. She continued to have exertional dyspnoea and was readmitted 9 months later with worsening dyspnoea. APS antibodies performed during both admissions were negative. Seronegative APS was diagnosed. Interestingly, two CTPAs performed at 6 months and 9 months after initial presentation revealed persistent bilateral pulmonary embolism. The provoking factors for PE should be sought because ‘unprovoked’ PE especially in young individuals need further attention. APS, including seronegative APS, should be considered. Persistence of symptoms of PE also warrants further attention as chronic thromboembolic pulmonary hypertension (CTEPH) may be the cause. Currently, there are available medical and surgical treatment of CTEPH, therefore establishing its diagnosis is important and it is best performed in pulmonary hypertension expert centre.International Journal of Human and Health Sciences Supplementary Issue-2: 2021 Page: S25
Structural and thermodynamic properties for the BaMn(Fe=V)F7 Fluoride glass system by using the Hybrid Reverse Monte Carlo simulation
Authors: Mesli Sidi Mohammed , Heddar S. , Habchi M. , Kotbi M. , Ziane M.
Published: September 2021

The Hybrid Reverse Monte Carlo (HRMC) simulation has been widely used as a very useful method for displaying the pair partial distribution functions (PDFs) g(r) eliminating as soon as possible the artificial satellite peaks appear by the RMC simulation. The HRMC is an extension of the RMC algorithm, which introduces an energy penalty term (potential) in the acceptance criteria.The glass retains the structure presented by the liquid at the glass transition temperature Tg, and the thermodynamic properties are influenced by these structural modifications. We are interested in this study to apply the structural parameters g(r), obtained from HRMC simulation, to determine some structural and thermodynamic properties for the BaMn(Fe=V)F7 Fluoride glass.The calculated structural properties such as the running coordination number n(r) were in good agreement with coordination constraint. We suggest also that the structural parameters g(r) is a good tool to determine the thermodynamic properties as the energy of the system.
Susceptibilities of invasive Neisseria meningitidis strains to agents used for prophylaxis and to penicillin G
Authors: Phillips Carrie , Haldane David JM
Published: September 2021

Background: The antimicrobial susceptibility of isolates of Neisseria meningitidis to agents used for chemoprophylaxis and to penicillin G was determined. Methods: Fifty N. meningitidis strains detected in Nova Scotia between 2004 and 2018 were included. The isolates were originally isolated from sites that might prompt chemoprophylaxis (27 blood, 18 cerebrospinal fluid [CSF], 3 CSF–blood, and 2 conjunctiva). Minimal inhibitory concentrations (MICs) were determined to azithromycin, ciprofloxacin, minocycline, rifampin, trimethoprim–sulfamethoxazole, and penicillin G, using a diffusion gradient strip on Mueller–Hinton agar with 5% sheep blood in 5% CO2 for 20–24 hours. Results: All isolates remained susceptible to azithromycin, ciprofloxacin, minocycline, and rifampin, but there was 26% resistance to trimethoprim–sulfamethoxazole. There was a rise in penicillin MIC of the isolates over the study period. Conclusion: In our province, N. meningitidis isolates causing invasive infection remain susceptible to commonly used antimicrobial agents used for chemoprophylaxis. Significant resistance to trimethoprim–sulfamethoxazole is present and the degree of susceptibility to penicillin G is lessening.
Presentación
Authors: Valdés Dávila Ma. Guadalupe , Díaz Barriga Frida
Published: September 2021

Dos son los acontecimientos significativos de la historia de la educación que permiten entender la instauración de la homogeneidad como racionalidad organizadora de las instituciones educativas. El primero de ellos corresponde a los sistemas educativos que se organizaron en Prusia en 1787 a partir de que Federico Guillermo II promulgara un código escolar en el que quitaba al clero el gobierno de las escuelas y lo encomendaba a un ministerio de educación que estaba organizado en oficinas desde las cuales los inspectores administraban y vigilaban el funcionamiento de las escuelas (Esteve, 2003, p. 37). El segundo hace referencia a la enseñanza universal como conquista de los pensadores e ideólogos de la Revolución francesa (Gadotti, 2003), desde la cual se instaura el sistema escolar de masas y, con ello, se impone un “igualitarismo” en función de un tipo ideal de alumno (González-Barrau, 2012). Esto marcará la historia de la educación en la modernidad y su traslado a los países coloniales que comienzan a pugnar por su independencia, pero que adoptan el contrato social y las premisas de los sistemas educativos europeos.
The Wolf in the Woods
Authors: Lantz Derek
Published: September 2021

A close reading of the cause and treatment of lycanthropy in Cherie Dimaline's Empire of Wild is used to discuss differences between Indigenous and Western views on justice, community, monstrosity, and human nature. Utilizing Rupert Ross's Returning to the Teaching: Exploring Aboriginal Justice to provide first-hand understanding of Indigenous justice concepts, Empire of Wild uses myth to provide a moral impetus for community-driven justice models. This paper looks at how myth is integrated into the story, how it differs from other lycanthrope myths, and what the ramifications of that difference means for both the plot and message of Empire of Wild.
Efficiency of Liposomal Gelcoat with Dihydroquercetin Flamena in Therapy of Vulvar Lichen Sclerosus
Authors:   Moscow Scientific and Practical Centre for Dermatovenereology and Cosmetology of the Moscow Department of Health, Moscow, Russian Federation, Chernova N.I. , Zadorozhnaya I.S. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health, Moscow, Russian Federation
Published: September 2021

Study Objective: To assess the therapeutic efficiency of liposomal gelcoat with dihydroquercetin Flamena in combination therapy of vulvar lichen sclerosus (VLS). Study Design: open comparative perspective study. Materials and Methods. The study included 52 patients with VLS aged 22 to 65 years. Patients were randomised into two therapeutic groups: 27 patients in group 1 had a standard course of therapy with ultrapotent topic glucocorticosteroids (tGCS) for 3 months; 25 patients in group 2 had a standard intermittent 3-month therapy with Flamena gel for 1.5 month. Therapy efficiency was evaluated using the Dermatological Symptom Scale, visual analogue scale, and Dermatological Quality of Life Index (DQoLI). Therapeutic manipulations were assessed during 6 visits. Study Results. Flamena gel facilitated clinical remission maintenance and prolongation. Starting from visit 4, there were differences between group 1 and group 2 values. By visit 5, group 2 patients demonstrated stable regression or reduction in white spots and papules/plaques (not more than 0.8 ± 0.35 and 0.5 ± 0.26 points, respectively). At the same time, group 1 had clinical symptoms intensity rising to 1.6 ± 0.87 points (white spots) and 1.2 ± 0.9 points (papules/plaques), correlating with subjective symptoms aggravation. Effects of therapy on DQoLI were demonstrated with reduction in mean values to 4.2 ± 2.6 points (group 1) and 3.2 ± 1.4 points (group 2) by visit 2. In group 2, the values remained at 3.3 ± 0.6 points by day 60 (visit 6) of follow-up, whereas in group 1 the VLS impact over quality of life increased from mild (4.2 ± 2.6 points — visit 2) to moderate (7.1 ± 2.3 points — visit 6) in a majority of study subjects. Conclusion. A comparative study demonstrated a marked therapeutic effect and high safety profile of Flamena gel in a combination therapy of VLS patients. It improves disease prognosis due to antiinflammatory, antiseptic and regenerative action, thus allowing reducing the frequency and amount of tGCS use. Keywords: vulvar lichen sclerosus, Flamena gel, vulvar itching
Association Between Pre-delivery Proteinuria and Pregnancy and Delivery Outcome in Patients with Preeclampsia
Authors:   V.I. Vernadsky Crimea Federal Institute, Simpheropol, Crimea, Pylaeva N.Yu. , Shifman E.M. ,   M.F. Vladimirsky Moscow Regional Clinical Research Institute, Moscow, Russian Federation, Kulikov A.V. ,   Ural State Medical University of the Ministry of Health of the Russian Federation, Ekaterinburg, Russian Federation, Pylaev A.V. ,   N.A. Semashko National Clinical Hospital, Simpheropol, Crimea
Published: September 2021

Study Objective: To assess the association between pre-delivery proteinuria (PU) in patients with preeclampsia and pregnancy/ delivery outcomes for mother and child. Study Design: retrospective study. Materials and Methods. We have conducted a retrospective study of 149 labour and delivery medical records of patients with PU diagnosed before delivery, who had preeclampsia during their pregnancy. Patients were divided into two groups depending on PU severity: moderate and significant PU. We studied the rate of complications for mother and foetus, pregnancy/delivery outcomes for foetus, and anthropometric and demographic parameters of mothers, their somatic conditions, and obstetric history. Study Results. Women with significant PU diagnosed before delivery demonstrated higher statistically and clinically significant risk of HELLP syndrome, as well as increased AAT and ALT activity vs. patients with moderate PU. As for outcomes for newborns, there was a clear statistically significant association between respiratory disorders in child and rate of pre-delivery PU in mother. This complication was recorded more frequently in newborns born to mothers with significant PU vs. moderate PU. Conclusion. An absolute PU quantification before delivery is a method to forecast unfavourable outcomes for mother and child. Keywords: preeclampsia, moderate proteinuria, severe proteinuria, pregnancy and delivery outcomes
Obstetric Complications and Pregnancy Outcomes in Patients with Endometriosis
Authors:   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation, Borisova A.V. , Konnon S.R.D. ,   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation, Plotnikova A.I. ,   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation, Khallyeva O.N. ,   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation
Published: September 2021

Objective of the Review: To study the impact of endometriosis on the course and outcomes of pregnancy; to propose methods for prevention of obstetrics complications in pregnant women with endometriosis. Key Points. Pregnant women with endometriosis are at a high risk of miscarriage, preterm delivery, preeclampsia, placental disorders, intranatal and postnatal bleeding, still birth, high rates of caesarean section; and at a risk of acute complications from endometriosis, e.g., spontaneous hemoperitoneum. Endometriosis is associated with progesterone resistivity, impaired endometrium receptivity; therefore, prescription of progesterone to pregnant women with endometriosis can be a key to prevention of not only miscarriages and preterm delivery, but also of preeclampsia and placental disorders. Folic acid has favourable effect for placenta formation. Low doses (75–150 mg/day) of acetylsalicylic acid prevent placentation disorders. Conclusion. In order to prevent impaired implantation, placentation, cytotrophoblastic invasion, and uteroplacental perfusion with a high risk of obstetric complications, pregnant women with endometriosis should take progesterone, folic and acetylsalicylic acids. Keywords: endometriosis, obstetric complications, pregnancy follow-up
Analysis of Risk Factors and Perinatal Mortality Structure in Pregnant Patients with Diabetes Mellitus
Authors:   Scientific and Research Institute of Obstetrics, Gynaecology and Reproductive Medicine named after D.O. Ott, St. Petersburg, Russian Federation, Kapustin R.V. ,   St. Petersburg State University, St. Petersburg, Russian Federation, Kopteeva E.V. ,   St. Petersburg State University, St. Petersburg, Russian Federation, Alexeenkova E.N. ,   Scientific and Research Institute of Obstetrics, Gynaecology and Reproductive Medicine named after D.O. Ott, St. Petersburg, Russian Federation, Tsybuk E.M. ,   St. Petersburg State University, St. Petersburg, Russian Federation, Arzhanova O.N. ,   Scientific and Research Institute of Obstetrics, Gynaecology and Reproductive Medicine named after D.O. Ott, St. Petersburg, Russian Federation,   St. Petersburg State University, St. Petersburg, Russian Federation
Published: September 2021

Study Objective: To analyse risk factors and perinatal mortality structure in patients with various types of diabetes mellitus (DM) over the last 30 years in specialised settings. Study Design: retrospective single-site cohort study. Materials and Methods. We have studied 42 medical records containing cases of perinatal death of foetus or newborn in 1988–2018 in patients with DM1 (n = 20), DM2 (n = 10), gestational DM (n = 12). Study Results. The most common complication in pregnancy was preeclampsia combined with chronic placental insufficiency (47.6%). The most common risk factors of perinatal death were inadequate glycemic control in 1st trimester (69.0%), absence of preconception preparations (66.7%), preconception overweight and obesity (42.8%), and chronic arterial hypertension (28.6%). There were 38.1% antenatal deaths, 16.7% intranatal deaths, and 45.2% cases of postnatal mortality. The major causes of perinatal foetal mortality in 26.2% cases were placental disorders, 16.7% were associated with foetus growth retardation, diabetic fetopathy and respiratory distress syndrome. Conclusion. DM during pregnancy was associated with a higher risk of perinatal death. Timely preconception preparation, BMI normalization and a consolidated approach to term and mode of delivery can reduce the risk of perinatal mortality in women with various types of DM. Keywords: diabetes mellitus, gestational diabetes mellitus, perinatal mortality, stillbirth, obesity, preeclampsia
Impaired Expression of Estrogen and Progesteron Receptors During the Implantation Window in Eutopic Endometrium of Infertile Women Associated with Endometriosis Genitalis Externa
Authors:   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation, Radzinsky V.E. , Orazov M.R. ,   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation, Mikhaleva L.M. ,   Scientific and Research Centre of Human Morphology, Moscow, Russian Federation, Volkova S.V. ,   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation, Khovanskaya T.N. ,   Scientific and Research Centre of Human Morphology, Moscow, Russian Federation, Shustova V.B. ,   MedInService LLC — Centre for Reproduction and Genetics Nova Clinic, Moscow, Russian Federation
Published: September 2021

Study Objective: To study impaired expression of estrogen (ER) and progesteron (PR) receptor isoforms during the implantation window in eutopic endometrium of infertile women associated with endometriosis genitalis externa (EGE). Study Design: open perspective comparative study. Materials and Methods. The study included 32 patients with endometriosis-associated infertility and implantation failures within the scope of assisted reproductive technology programme (study group), and 33 fertile women with EGE rAFS (stages I to IV) (comparison group). We performed morphological and immunohistochemical examination of endometrium biopsy samples (pipelle biopsy) during an expected implantation window. Study Results. Eutopic endometrium of women with EGE and infertility during the implantation window demonstrated statistically higher (р < 0.05) expression of ERα (19-fold), ERβ (2.3-fold) in stroma and PR-B in glands (1.7-folds) as compared to fertile women win EGE with lower PR-A expression in stroma (2.5-fold). Conclusion. The morphofunctional condition of endometrium and its receptive properties during the implantation window in women with endometriosis-associated infertility reflect the nature of ER (α and β) and PR (А and В) isoforms expression, the abnormalities underlying the endometrium receptivity disorders, with clinical manifestations being absent pregnancy. Keywords: endometriosis-associated infertility; implantation window; endometrium receptivity
Pathogenesis of Implantation Incompetence of Endometrium in Endometriosis-Associated Infertility
Authors:   Scientific and Research Centre of Human Morphology, Moscow, Russian Federation, Mikhaleva L.M. , Orazov M.R. ,   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation, Volkova S.V. ,   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation, Khamoshina M.B. ,   Peoples’ Friendship University of Russia (a Federal Government Autonomous Educational Institution of Higher Education), Moscow, Russian Federation, Khovanskaya T.N. ,   Scientific and Research Centre of Human Morphology, Moscow, Russian Federation, Shustova V.B. ,   MedInService LLC — Centre for Reproduction and Genetics Nova Clinic, Moscow, Russian Federation
Published: September 2021

Study Objective: To expand the idea of the pathogenesis of implantation incompetence of endometrium in women with endometriosis-associated infertility. Study Design: open perspective comparative study. Materials and Methods. The study enrolled 78 women. The study group included 32 patients with endometriosis genitalis externa (EGE) and infertility; the comparison group included 33 patients with EGE who used their reproductive function not more than 3 years before the study and who were not diagnosed with infertility; the group of morphological control made 13 fertile women without EGE. The subject of the study was endometrium biopsy material obtained on day 5–7 of menstruation, following the peak blood concentration of luteinizing hormone during the expected implantation window. Study Results. When patients with endometriosis-associated infertility were compared to fertile women with EGE, we noted increased expression of GATA2 — 1.6-fold, GATA6 — 1.7-fold, SF-1 — 1.5-fold and reduced HOXA10 expression by 2.9 times (p < 0.05 in all cases) in stroma of infertile women. When patients with endometriosis-associated infertility were compared to fertile women without EGE, we recorded statistically significant (р < 0.05) increase in expression of GATA2 in stroma (2.5-fold) and glands (2.2-fold), GATA6 and SF-1 in stroma (2-fold in both cases), and reduced HOXA10 expression both in stroma (3.6-fold) and glands (2.8-fold). Conclusion. Pathogenesis of implantation incompetence of endometrium in endometriosis-associated infertility is caused by impaired endometrium receptivity because of aberrant expression of transcription factor affecting local hormonal balance. Keywords: endometriosis-associated infertility, implantation incompetence of endometrium
Metformin Efficiency in Genital Endometriosis Management
Authors:   Scientific and Research Institute of Obstetrics, Gynaecology and Reproductive Medicine named after D.O. Ott, St. Petersburg, Russian Federation, Yarmolinskaya M.I. , Florova M.S. ,   I.I. Mechnikov Northwestern State Medical University, Russian Ministry of Health, St. Petersburg, Russian Federation
Published: September 2021

Study Objective: To assess clinical efficiency of combination therapy with Metformin and Metformin monotherapy in the management of endometriosis genitalis externa (EGE). Study Design: perspective randomised singe-arm study in parallel groups. Materials and Methods. 146 patients with pain syndrome associated with endometreosis were treated with one therapy option for 6 months: Dienogest 2mg/d (group 1, n = 32); Dienogest 2mg/d + Metformin 1,500mg/d (group 2, n = 61); Dienogest 2mg/d + Metformin 750mg/d (group 3, n = 29); Metformin 1,500 mg/d (group 4, n = 24). The intensity and prevalence of dysmenorrhea, dyspareunea, chronic pelvis pain (CPP) before and after treatment were evaluated. Study Results. In group 2, pain syndrome became less intensive in 85.2% of EGE patients. Dysmenorrhea reduction was statistically more frequent (p = 0.031), CPP was less intensive (p = 0.027), as compared to the standard Dienogest therapy. 75.9% of group 3 patients and 66.7% of group 4 patients had less intensive pain syndrome. There were no statistically significant differences in therapy results between group 3 and group 4 and Dienogest monotherapy. Conclusion. Combination of Dienogest (2mg/day) and Metformin (1,500mg/d) allows boosting the efficiency of therapy of endometreosis-associated pain syndrome. Personification of pathogen-specific EGE management with individualised selection of a drug combination and Metformin dose is a promising option. Keywords: endometreosis, pain syndrome, Dienogest, Metformin
Between Uterine Fibroid and High Cardiovascular Risk in Premenopausal Women
Authors:   Kuban State Medical University of the Ministry of Health of the Russian Federation, Krasnodar, Russian Federation, Bolotova E.V. , Dudnikova A.V. ,   Kuban State Medical University of the Ministry of Health of the Russian Federation, Krasnodar, Russian Federation, Krutova V.A. ,   Kuban State Medical University of the Ministry of Health of the Russian Federation, Krasnodar, Russian Federation, Pirozhnik E.G. ,   Kuban State Medical University of the Ministry of Health of the Russian Federation, Krasnodar, Russian Federation, Konchakova E.A. ,   Kuban State Medical University of the Ministry of Health of the Russian Federation, Krasnodar, Russian Federation
Published: September 2021

Study Objective: To assess the association between major factors of cardiovascular risk and uterine fibroid in premenopausal women. Study Design: full prospective study. Materials and Methods. The study included 296 patients (mean age: 44.76 (5.65) years old). Patients were divided into two groups: study group — 160 women with confirmed uterine fibroid, and controls — 136 women without uterine fibroid, of similar age (44.36 (6.78) and 45.17 (5.23) years, respectively). Study Results. As compared to controls, women with fibroid had statistically higher rate of arterial hypertension (AH) (33.1% vs 10.3%, respectively, χ2 = 21.8, p = 0.001), metabolic disorders (7.5% vs 2.2%, χ2 = 4.283, р = 0.03), hypercholesterolemia (37.5% vs 18.3%, χ2 = 18.524, р = 0.001), overweight (35% vs 23.5%; χ2 = 4,.63, p = 0.03), and mean waist/ hip circumference ratio (р = 0.02). Regression analysis demonstrated independent positive correlations between uterine fibroid and AH (OR = 2.02; 95% CI: 1.25–3.27, р = 0.004), hypercholesterolemia (OR = 2.51; 95% CI: 1.82–3.79, р = 0.001), abdominal obesity (OR = 2.98; 95% CI: 1.95–4.19; р = 0.004), metabolic disorders (OR = 2.43; 95% CI: 1.23–4.79; р = 0.01). There were no statistically significant differences in the rate of smoking, anaemia, body mass index, main reproductive parameters between groups. Conclusion. Available information shows that the cardiovascular risk profile in premenopausal women is worse than in controls. A comprehensive study of metabolic and cardiovascular risk profiles and their association with uterine fibroid is required; it will allow mitigating the cardiovascular risk in this group of women by the time they enter the menopause. Keywords: cardiovascular risk factors, uterine fibroid
Comprehensive Approach to Rehabilitation of Women with Postradiation Complications as a Result of Prior Endometrial Cancer (Case Report)
Authors:   V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynecology and Perinatal Medicine of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Kazakova S.N. , Teterina T.A. ,   V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynecology and Perinatal Medicine of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Apolikhina I.A. ,   V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynecology and Perinatal Medicine of the Ministry of Health of the Russian Federation, Moscow, Russian Federation,   I.M. Sechenov First Moscow State Medical University (Sechenov University) (a Federal Government Autonomous Educational Institution of Higher Education), Russian Federation Ministry of Health, Moscow, Russian Federation, Ischuk M.P. ,   Voronezh State Medical University named after N.N. Burdenko of the Ministry of Health of the Russian Federation, Voronezh, Russian Federation
Published: September 2021

Objective of the Paper: To assess the efficiency of a comprehensive approach to the management of pelvic postradiation complications in women. Key Points. Pelvic damages from radiation (postradiation proctitis, cystitis, urethritis) are the most common complications following pelvic radiation in women. According to various authors, the rate of late pelvic complications can reach 30%. A third of survivors are diagnosed with a new disease, which significantly deteriorates the quality of life and required long-lasting therapy. The article describes a case report of successful therapy in a patient with postradiation pelvic complications. Conclusion. The conservative treatment of postradiation pelvic complications makes it possible to improve the quality of patients’ life, especially if initiated immediately after surgery and radiation. The most efficient mode is a combination of local, drug and physical therapy. Keywords: postradiation cystitis, endometrial cancer, rehabilitation of endometrial cancer survivors, ammonium dermatitis, Ingaron
Adolescent Internet Gaming Disorder: A Narrative Review
Authors: Field Tiffany
Published: September 2021

This narrative review is based on a literature search on PsycINFO and PubMed that involved entering the terms adolescent internet gaming for papers published during the last five years. Following exclusion criteria, 72 papers could be classified as internet gaming or internet gaming disorder/addiction studies including research on the prevalence, effects/comorbidities, risk factors and interventions for those problems. The prevalence of both internet gaming and internet gaming disorder has varied by culture. The effects/comorbidities have included hyperactivity, inattentiveness, cyberbullying, depression, anxiety and substance use. The risk factor studies have focused on impulsivity, sensation-seeking, and aggressivity. Altered autonomic and central nervous system function have also been notable including decreased heart rate variability and fMRI data showing less activation of the prefrontal cortex, ventral striatum and amygdala (areas that are involved in modulating impulsivity, reward-seeking and aggression respectively) as well as reduced gray and white matter. Surprisingly, given the prevalence and severity of internet gaming disorder, very little prevention/intervention research appears in this recent literature. Research is also missing on peer relationships/rejection as potential risk factors. Like other literature on adolescent problems, this research is limited by primarily deriving from self–report and parent report and by the absence of longitudinal data that might inform whether the behavioral and brain data being reported are effects of or risk factors for internet gaming addiction.
Aleyrodes borchsenii Danzig, 1966 is a junior synonym of A. lonicerae Walker, 1852 (Homoptera: Aleyrodidae)
Authors: Danzig E.M.
Published: September 2021

Aleyrodes borchsenii Danzig, 1966 is placed in synonymy with A. lonicerae Walker, 1852.
ANALYSIS OF TRAFFIC CONGESTION AT TRANSPORT TRANSFER HUBS USING DRONES
Authors:   Saint Petersburg State University of Aerospace Instrumentation, Kostin A. S.
Published: September 2021

This article considers the possibility of using drones to identify and analyze the congestion of traffic-transfer hubs in the urban environment. The article substantiates the need to analyze the congestion of traffic-transfer hubs, due to the unevenness of traffic congestion. Classical models of congestion estimation do not allow taking into account the dynamics of the process. The data obtained by manual calculations contain errors and require lengthy processing. Using the data from cameras allows solving the problem of congestion analysis, but it is not possible to solve this problem with high accuracy during peak hours. The use of data obtained from drones (from an unmanned aerial system) is proposed to solve the congestion analysis problem. To implement this solution, the article presented a list of necessary components that a drone should have, an example of the source code for the implementation of an autonomous flight, an example of the implementation of the traffic-transfer hubs overflight scheme using special software.
ANALYSIS OF HARDWARE SYSTEMS FOR THE DELIVERY OF PARTICULARLY IMPORTANT CARGO USING UNMANNED AIRCRAFT SYSTEMS
Authors:   Saint Petersburg State University of Aerospace Instrumentation, Silin Y. A.
Published: September 2021

The article briefly discusses the possibilities of using quadrocopters for fast delivery of especially important goods and provides examples of possible hardware systems that can provide this. The given examples were analyzed and compared with each other, as a result of which a conclusion was made about the optimality of choosing the design of the hardware complex for each type of cargo.
Deformations of the Russian labor market inthe context of the use of cheap foreign labour: re-immigration and labor standards
Authors: Sedlov Aleksey
Published: September 2021

The algorithms of re-immigration in recipient and donor countries are considered by the author in the global context. The author maintains that in Russia cheap labor resources from the CIS countries are the reason for the low price of labor, and re-immigration has not become a starting point for the revision of the norms of minimum labor standards and preferences for national personnel. It is noted that re-immigration has increased the shortage of workers, and the migration policy, under the pressure of business, has fixed the course towards attracting additional working hands from the poor countries of Central Asia. The assessment methodology is proposed and calculations of the demand and supply of foreign labor in the Russian labor market are made, taking into account its conjuncture, illegal migration and the possibility of replacing foreigners with Russians.
The competitiveness of industry in the northern regions of Russia: from profits to people
Authors: Styrov Maxim
Published: September 2021

The article presents a new approach to assessing the competitiveness of economic activities. The author proposes a calculation of all the main indicators per employee in order to analyze the internal integrity of the economic system. The homogeneity of economic subsystems is analyzed in a new dynamics through the coefficient of variation in three aspects - interregional, interindustry and between indicators. On the example of the industry of the northern regions of Russia, ultra-high intersectoral and interregional disparities are revealed. The thesis is put forward about the need to overcome the existing problems.
Chemical Contamination in Packaging Material of Pharmaceutical Use
Authors:   University of Agronomic Science and Veterinary Medicine, Bucharest, Romania, Clotea D. , Ungureanu E. ,   University of Agronomic Science and Veterinary Medicine, Bucharest, Romania, Mustatea G. ,   National Research & Development Institute for Food Bioresources, Bucharest, Romania, Popa M. ,   University of Agronomic Science and Veterinary Medicine, Bucharest, Romania
Published: September 2021

The use of packaging materials is important in the pharmaceutical industry. The pharmaceutical industry uses, as primary packaging materials, glass bottles, blister packs, caps, and closures, glass vials, sealed tubes. The aim of this study is to perform global component migration analyses on these types of packaging, to see if there is a possibility of migration of components from the pharmaceutical package into the drug, so as not to alter in any way its therapeutic properties. The results obtained from the processing of the extracts obtained were below the maximum limits allowed for each category of packaging, respectively, plastic, paper and cardboard, glass.
New fixed point results about F-contractions in a complete metric space
Authors:   Transilvania University of Brasov, Romania, Proca Alexandrina Maria
Published: September 2021

In this paper, we extend the results of Wardowski by applying some new conditions on the self map on a complete metric space, concerning the Fcontractions defined by Wardowski. We present some fixed point results of Wardowski type. An example is given to demonstrate the novelty of our work.
On representation of a first degree spline function
Authors:   Transilvania University of Brasov, Romania, Scheiber Ernest
Published: September 2021

A presentation of related global representations for the first degree spline function is given, revisiting some known results. The given global representations are deduced one from another by simple transformations.