bluuebunny/crossref_metadata_2025 huggingface dataset:
GENOTYPE BY ENVIRONMENT INTERACTION OF ADVANCED SOYBEAN BREEDING LINES IN LAMPUNG UPLAND SOILS
Authors: Arsyad Darman M. , Purwantoro ,
Published: February 2019

Availability of adapted cultivars is needed for the development of soybean cultivation in upland soil in Lampung, Sumatra. Twelve advanced soybean breeding lines and two check varieties (Tanggamus and Wilis) were tested on upland soils of Lampung Province. The trials were conducted in the District of Tulangbawang, Central Lampung, East Lampung and South Lampung during the late rainy season of 2003/2004. Two sites were selected per district for a total of eight sites for the four districts. A split plot design with three replications was used within each location. Plot size was 2.4 m x 4.5 m, plant spacing of 40 cm between rows and 15 cm within a row, and two plants per hill. The mainplot was fertilizer: A= Low inputs (22.5 kg N, 27 kg P2O5, and 40 kg K2O per ha), and B=Medium inputs (22.5 kg N, 36 kg P2O5, 53 kg K2O and 0.56 t CaO per ha). The fertilizers were applied before planting. The subplots were 12 soybean breeding lines together with two check soybean varieties. Results showed that soybean yields were affected significantly by locations, fertilizers, breeding lines, location x fertilizer and location x breeding line interactions. Plant height was affected siginificantly by locations, fertilizers, breeding lines and location x breeding interaction. Pods per plant  were affected by locations, fertilizers, location x fertilizer and location x breeding line interactions. All breeding lines and varieties were responsive to changing environments. Based on the smallest Pi parameter (the distance mean square between the cultivar’s response and the maximum response averaged over all locations), and the highest frequency of rank, three breeding lines, namely W3465-27-2 (released in 2004 as cv. Ratai), cv. Tanggamus and D3578- 3/K3911-66-3 were identified as wide adaptability genotypes with the yield potential of more than 2.4 t/ha with an average of 1.6 t/ha.
STABILITAS DAN ADAPTABILITAS HASIL JAGUNG HIBRIDA DR UNPAD DI TIGA LOKASI PADA DUA MUSIM TANAM DI JAWA TIMUR, INDONESIA
Authors: Aprilianti R. , Ruswandi D. , P. Anggia E. , Hastini Tri , Suhada A. , Istifadah N. , Ismail A. , Suryadi E. , Ruswandi S. , Rostini N.
Published: February 2019

Study adaptability is an important step to select superior hybrids which have wide adaptability or specific adaptability. Fifhteen of DR Unpad hybrids have purpose to know about stability and adaptability for yield characters (yield ton/ha), ear weight of plot (kg), ear weight of sample (kg), and grain weight of sample (kg) of DR Unpad hybrids in East Java and to determine GxE interaction on two plant seasons for build up superior variety in Indonesia. Three location and each location two seasons, fifhteen hybrids and four tester cultivar were tested and randomized complete block design with three replications. Data were analysis of variance, complete analysis variance, and AMMI. The results indicated that there was GxE interaction  for yield character. Thus, for yield performance, hybrids Var R showed high stability and high yield. Var R, C, and Var G have a wide adaptability for yield. Var C and R had specific  adaptation in marginal location in Sidoarjo  on second season. And hybrids Var F and Var B specific for Ngronggot on second season which that location was a good environment.
Hubungan Produksi dan Kandungan Protein Padi Populasi F3 Hasil Persilangan G39 x Milky Rice dan G39 x Ciherang
Authors: Fitriyani , , Riyanto Agus , Susanti Dyah , H. Totok Agung D.
Published: February 2019

Rice is one of the commodity that is very important as a staple food for more than 95% of the population in Indonesia. Rice production should be increase continously in line with the increasing population of Indonesia. Therefore, it is important to improve the quality and quantity of the production of rice. Improvement in terms of quality through development of rice with high protein content, beside of its production. Protein content in rice grain be important because it serves as an essential nutrient that can be used in the growth and cell recovery. This research be conducted in the village Sokawera, district Baturaden, Banyumas Regency. The material used is a population of F3 results of crossing with G39 x Milky Rice and G39 x Ciherang. The results showed the highest protein content in population of crossing G39 x Milky Rice is amount 13.42%. and a crossing G39 x Ciherang is amount 13.05%. The value of the correlation of protein content with component output is -0.36. There is no relations between production rice and its protein content.
Phenotypic appearance the yield character of five genotypes of cayenne pepper at Sukamantri, Ciamis
Authors: Oktaviani Eva , Rostini Neni , Karuniawan Agung
Published: February 2019

The purpose of this experiment is to evaluate the phenotypic appearance the yield character of five genotypes of cayenne pepper at Sukamantri, Ciamis region. The experiment used a randomized block design, with five replications. The experiment material consists of five genotypes of cayenne pepper, namely Unpad Ratuni, CR8873, Dewata, Taruna, and Rabani. The experiment was conducted at Sukamantri, Ciamis with altitude of 983 m above sea level (asl.) from August 2017 to February 2018. Data observed included fruit length, fruit diameter, fruit weight per fruit, fruit weight per plant, fruit weight per plot, and fruit weight per hectare. The experiment results show that there are differences in phenotypic characters among the five genotypes tested. Genotypes of the Gods, CR8873, and Ratuni Unpad show the highest potential yield (10.961 ton/ha, 0.345, and 10.232), with fruit weight of fruit per 1.382 gram, 0.911 grams, and 1.311 grams.Keywords: cayenne pepper, phenotypic character, yield
Evaluasi Program Supervisi Akademik di PAUD Swasta
Authors: Kurniawan Daniel , Dwikurnaningsih Yari , Sulasmono Bambang Suteng
Published: February 2019

This study was designed to evaluate academic supervision program at PAUD Tunas Kasih, Magelang, using Context, Input, Process, Product (CIPP) evaluation model. The results of the study were expected to provide inputs to decision-makers for subsequent programs. The respondents of this descriptive-qualitative research included the school principal, six teachers, and a school managerial staff. Data collection was done through interviews, observation and document studies. Triangulation of data sources and methods validated the data, subsequently analysed through data condensation, data display, conclusion drawing and verification. Findings indicated the context evaluation revealed a need for academic supervision based on the condition and the need for teacher’s quality improvement. The input evaluation described the well-planned program—using different techniques, involving the teachers in their readiness, supported by available budget and infrastructure. The process evaluation reported the implementation of the planned techniques, with some adjustments based on the on-going condition, supported by the teachers’ readiness as well as participation and how they handle the constraints. The product evaluation found out that the academic supervision program had positive impacts and achieved the planned goals. It also discovered teachers’ positive responses and some follow-up plans. Lastly, this study gave recommendations to improve the local supervision programs, inputs to the school management, and ideas for future researches.
Penyegaran Tentang Metode Penelitian Ilmiah Untuk Widyaiswara
Authors: Sitanggang Yuliana Ria Uli
Published: February 2019

Producing a scientific article is one of the requirements that must be met by the Widyaiswara (civil servants who are responsible for doing education and training for other civil servas) to be able achieve higher level of rank and positions. This paper is intended to motivate the Widyaiswara in conducting scientific research. This article briefly discusses about the relevance of knowledge and research, the research processes, the hypothetical example of scientific research and scientific research ethics.
Solution of a mathematical model for the treatment of rheumatoid arthritis
Authors: Matteucci L. , Nucci M. C.
Published: February 2019

Rheumatoid arthritis is an autoimmune disease of unknown etiology that manifests as a persistent inflammatory synovitis and eventually destroys the joints. The immune system recognizes synovial cells as not self and consequently causes lymphocyte and antibody proliferation that is promoted by the pro-inflammatory cytokines, the most significant being tumor necrosis factor TNF-α. In the treatment of rheumatoid arthritis either monoclonal antibodies or soluble receptors are used to neutralize the TNF-α bioactivity, such as sTNFR2, Etanercept and Infliximab. In [M. Jit et al. Rheumatology 2005;44:323-331] a mathematical model that represents the TNF-α dynamics in the inflamed synovial joint within which locally produced TNF-α can bind to cell-surface receptors was proposed. It consists of four coupled ordinary differential equations, that were integrated numerically assuming a range of estimates of the key parameters. In this paper we complement the previous work by determining the general solution of those equations for specific conditions on the parameters. Then we characterize the behavior of TNF-α in the presence of different inhibitors and also evaluate the inhibitors effectiveness in the treatment of rheumatoid arthritis.
Snow-bed communities with dominant Salix herbacea in the Julian Alps
Authors: Martinčič Andrej , Wraber Tone , Dakskobler Igor
Published: February 2019

In the alpine belt of the Julian Alps (glacial cirque Na Jezerih under Mt. Veliki Rokav, Jarečica, the Mangart Saddle and Prodi under Mt. Mangart as well as Mt. Plešivec in the rock wall of Loška Stena) we studied the phytosociology and ecology of snow-bed vegetation with dominating flowering plants Salix herbacea, Luzula alpinopilosa, Gnaphalium supinum, Soldanella pusilla and Salix retusa, and numerous moss species. Based on the comparison with similar snow-bed communities in the Central, Eastern and Southern Alps we described a new association Salicetum retuso-herbaceae and classified it into the alliance Salicion herbaceae and class Salicetea herbaceae. We determined several successional stages of snow-bed vegetation on mixed calcareous-silicate bedrock that we treat as variants, in two relevés also the initial association Polytrichetum sexangularis.
Population genetic structure and genetic diversity study in Lallemantia royleana (Benth.) Benth.: identification of potential gene pools in Iran
Authors: Koohdar Fahimed , Sheidai Masoud , Talebi Seyed Mehdi
Published: February 2019

Lallemantia royleana (Benth.) Benth. (Family Lamiaceae), is one of the most popular medicinal plants in Iran. It is an herbaceous pant that is commonly known as “Lady mantle”. The vernacular name of Lallemantia royleana’s seed is Balangu or Balangu Shirazi that is used as a source of medicine. Medicinal plants are very important from economic point of view in Iran and several large industries are focused on medicinal plants cultivation, extraction and export. Therefore, providing data on the biology of these plants is important for the country. Lallemantia royleana grows in different parts of Iran and forms several local populations. Genetic, morphological and biochemical divergence of geographical populations are well known in plant species. We have no report on population genetic structure, genetic fragmentation, local adaptation and gen flow of Lallemantia royleana populations in the country. Therefore, the present population genetics investigation was programmed to produce data on above said questions. Randomly collected plants of 7 geographical regions were studied by ISSR molecular markers. This information can be used in hybridization and gene conservation of this medicinal plant in Iran.
Mining Activity and its Remains - The Possibilities of Obtaining, Analysing and Disseminating of Various Data on the Example of Miedzianka, Lower Silesia, Poland
Authors: Kawiecka R. , Krawczyk A. , Lewińska P. , Pargieła K. , Szombara Stanisław , Tama A. , Adamek K. , Lupa M.
Published: February 2019

The article presents comprehensive documentation of the situation of post-mining Miedzianka village (former town), which is located in Lower Silesia, in south-western Poland. Due to the long-term expansive mining exploitation since the 14th century, over time Miedzianka was completely destroyed and depopulated, thus nowadays, only a few inhabitants live there. The basis for the conducted research area were changes in land and urban structure that have been occurring for centuries in connection with mining operation of copper and uranium. The authors focused on presenting the changes using archival cartographic documentation, land surveying measurements and 3D modelling. That data allowed to determine on the ground specific sites related to mining operations, discover old urban buildings, performing their 3D models and finding places potentially threatened by continuous and discontinuous deformations. The combination of all the data allowed to present the full situation that occurred in Miedzianka.
Forests and Climate Change in Czechia: an Appeal to Responsibility
Authors: Fanta Josef , Petřík Petr
Published: February 2019

Forests cover more than one third of the area of Czechia and provide many environmental, economic, social and cultural benefits. Only a small part of the country´s forested area is left to nature. Most Czech forests are managed, with Norway spruce as the main tree species. The ongoing climate change progressively creates new conditions for the functioning of forests as important components of the landscape and providers of ecosystem services for society. Until recently, Czech forestry policy makers had not paid enough attention to climate change. As a result, Czech forests grapple with increasing instability caused by repeated windstorms, droughts and insect plagues. Traditionally applied management methods and rigid business models are not suitable for resolving the situation. Czech forestry thus takes an exceptional position within Europe. The responsibility for the development of the adaptation strategy and sustainable management policy lies in the hands of forestry policy makers. In order to restore stability and to ensure multifunctionality of forests under new climatic conditions, it will be necessary to introduce a new model of forest management. Compared to the traditional forestry model based on age classes, the new management model must be more flexible and better adapted to the new environmental situation. The principles of the new forestry policy should stem from agreement and cooperation of the forestry sector with scientific and nature protection institutions, as well as from an active discussion within society.

The starting point of the change are the documents Strategy of Adaptation to Climate Change under the Conditions of the Czech Republic and National Action Plan, elaborated in 2016 and 2017 by the Ministry of the Environment, and the Strategic Framework Czech Republic, approved by the Czech government. The chosen adaptation strategy and its implementation must not only restore the stability of forests, but also improve the future position of the Czech forestry sector among European countries.
Development and Present State of Close-to-Nature Silviculture
Authors: Remeš Jiří
Published: February 2019

Close to nature silviculture is an alternative to a forest management system based on the clear cutting regeneration and cultivation of even-aged coniferous monocultures. The history of close to nature silviculture dates back to the second half of the 19th century, when the first attempts were made in Central Europe for more sophisticated silvicultural practices based on natural small-scale regeneration and management of mixed stands. These activities also affected the Czech lands, where the ideas of close to nature silviculture were successfully developed by the end of the 1960s. For the next twenty years, however, under the influence of central planning, forest management has been inclined towards large-scale clear cutting system. The renaissance of close to nature forest management took place only after 1989. At present, close to nature silviculture being established not only in Central Europe, but also more and more in the boreal part of Europe as well as in North America. Currently, there is a discussion about suitability of close-to-nature silviculture for adapting temperate forests to climate change.
Invasion of Schrader’s Bromegrass (Bromus catharticus) and Expansion of the Cairo Suburban Land: are they in Coincidence?
Authors: Kovář Pavel
Published: February 2019

Set of phytocoenological records obtained in nineties of the twentieth century from extensively farmed patches and/or grasslands dominated by invasive grass Bromus catharticus in suburban area of Cairo, Egypt, is related to running and perspective expansion of this vegetation formation in the “city ecotone” at the metropolitan boundry.
Arianism in English Nonconformity, 1700-1750
Authors: Moga Dinu
Published: February 2019

During the time of English Nonconformity, Arianism was not only embraced, but openly acknowledged by most of the Presbyterian ministers. That generation of ministers, who contended so zealously for the orthodox faith, had finished their labours, and received from their Lord a dismissal into eternal rest. Those champions among the laity who, at the beginning of the controversy, stood up so firmly for the truth, had entered as well into the joy of their Lord. Though their children continued Dissenters, too many of them did not possess the same sentiments or spirit. Among those who succeeded these ministers were too many who embraced the Arian creed. To this unhappy change contributed the example and conversation as well of many from the younger Presbyterian ministers. In consequence Arianism spread far and wide in the Presbyterian congregations, both among the ministers and the people. This unhappy controversy proved the grave of the Presbyterian congregations, and of those of the General Baptists. The effects of Arianism, though at first scarcely visible, gradually produced desolation and death.
Age-Related Differences in Fitness Performance and Technical Skills of Young Soccer Players
Authors: Lipecki Krzysztof
Published: February 2019

Introduction
. The aim of the study was to identify differences in the level of fitness and technical skills of young soccer players depending on age.

Material and methods
. The study examined 140 male elite soccer players from the Polish Sport Academy aged 12 to 18 years. Body mass, body height, fitness abilities (5-m, 10-m, and 30-m sprint; envelope run; standing long jump; pull-ups; and beep test) and technical skills (ball handling, juggling alternately with the leg and the head, short passes, and long passes) were measured.

Results
. Statistically significant (p < 0.05) differences indicating improvement with age were found in older players in speed (15.5%-18.8%), agility (5.7%), lower limb explosive power (39.4%), upper limb strength (254.3%), and cardiorespiratory endurance (31.9%). With regards to technical skills, the greatest progress was documented for long shots (passes) with the internal instep from the ground (140.6% for the dominant leg, DL, and 730.3% for the non-dominant leg, NDL). Slightly lower results were obtained for short shots (passes) with the central instep from the air (128% for DL and 103.6% for NDL) and short shots (passes) with the medial part of the foot (52.1% for DL and 82.8% for NDL), and the lowest were recorded for ball handling with direction change (32.3% for DL and 29.9% for NDL).

Conclusions
. In the process of talent identification and monitoring of training effects, coaches should take into account the differences in the rate of the development of fitness and technical skills of young athletes.
Correlates and Predictors of Self-Assessments of Health and Physical Fitness Among Female Participants of University of the Third Age Classes
Authors: Krynicki Bartłomiej , Guszkowska Monika , Kozdroń Ewa , Niedzielska Ewa , Piotrowska Joanna , Leś Anna
Published: February 2019

Introduction
. We tested how female University of the Third Age (U3A) attendees evaluated their health, physical fitness, and satisfaction with health. We also examined various factors potentially underlying those self-assessments, that is objective indicators of health and physical fitness, their potential determinants (age and financial situation), and potential modifiers of self-assessment (mood, perceptive ability, and education).

Material and methods
. A total of 116 female participants attending U3A classes in Warsaw aged 50-88 years evaluated their health and fitness on a 100-level visual scale and their satisfaction with their health on a five-level Likert scale. Each participant completed the UWIST mood adjective checklist (UMACL) by Matthews, Chamberlain, and Jones and Yesavage’s geriatric depression scale, underwent the Fullerton fitness test, a hand grip strength test, Romberg’s test, and Ciechanowicz and Stanczyk’s attention and perception test, as well as filling out a specially designed questionnaire.

Results
. Self-assessments of health were found to correlate with aggravated symptoms of depression and certain components of physical fitness, but not with age or financial situation. Self-assessments of physical fitness, in turn, were strongly correlated with objective indicators of physical health and depression and less strongly with dexterity test results. General satisfaction levels, in turn, were found to be associated with long-term conditions, aggravated symptoms of depression, and financial situation.

Conclusions
. Overall, our results confirm that self-assessments are a moderately accurate indicator of the general health and physical fitness of elderly people: they correlated to a certain degree with more objective indicators of health/fitness but were influenced by modifying factors, particularly cognitive ones.
Influence of Wavelength of Light on Growth, Yield and Nutritional Quality of Greenhouse Vegetables
Authors: Olle Margit , Alsiņa Ina
Published: February 2019

All previous reviews of research on light-emitting diodes (LEDs) have been focused on how different light spectra generally influence plant yield and quality. There are no or almost no reviews on the effect of spectra on sugars or pigment concentration, or yield and growth etc. The role of visible light in food production, as in agriculture and horticulture, is obvious, as light drives photosynthesis, which is crucial for plant growth and development. Solid state lighting using LEDs represents a fundamentally different technology from gaseous discharge-type lamps currently in use. LEDs are important lamp types because the concentration of the light spectrum they emit can be changed to provide plants at various developmental stages with the light spectrum needed. A great deal of studies have been done on the effect of wavelengths of light on growth, yield and nutritional quality of greenhouse vegetables. However, little is known about the mechanisms by which the spectra affect sugar and pigment concentration, and yield, and growth. This article provides a list of how spectra influence the yield, growth, and nutritional quality of greenhouse-grown vegetables. Based on the given information we can conclude that blue, green, and red light are the main light colours that influence positively plant yield, growth and nutrient quality. Sometimes in specific situations, some other light colours are also beneficial, like far red light, orange light and UVA light. Future work on light colour manipulation has potential for producing lamps and greenhouse covers that better support plant yield, growth, and nutrition.
HLA Class II-DRB,-DQA and –DQB Genotypes in Peripheral Blood Shows Shifts During the Course of Sepsis
Authors: Bāra Linda , Eglīte Jeļena , Ošs Pēteris , Cauce Vinita , Lietuvietis Vilnis , Vīksna Ludmila , Hagina Elvīra , Krūmiņa Angelika
Published: February 2019

Undeniably, sepsis is still a profoundly damaging and life-threatening condition for many individuals. With multiple changes in sepsis patients it is difficult to precisely classify an individual’s response in sepsis as proinflammatory or immunosuppressed. The aim of this study was to investigate genetically determined predisposition to developed sepsis by analysis of distribution of human leukocyte antigen (HLA) class II genes. Samples from patients with sepsis were collected at Pauls Stradiņš Clinical University Hospital, Latvia, in an intensive care unit between October 2016 and May 2017. The study group included 62 patients with sepsis, who were genotyped for HLA-DR; DQ using real time polymerase chain reaction – sequence specific primer (RT PCR-SSP). As a control group, data of 100 individuals were taken from the genetic bank of RSU Joint Laboratory of Clinical Immunology and Immunogenetics. The summarised results showed that the frequency of alleles DRB1*04:01 (OR = 5.54; 95% CI = 1.88–16.29); DRB1*07:01 (OR = 19.03; 95% CI = 2/37–152.82); DQA1*05:01 (OR = 14.17; 95% CI = 5.67–35.4); and DQB1*02:01 (OR = 50.00; 95% CI = 2.90–861.81) were significantly increased in patients with sepsis compared to the control group patients. The frequency of DRB1*16:01 (OR = 0.17, 95% CI = 0.04–0.59); DRB1*17:01 (OR = 0.04; 95% CI = 0.00–0.69); DQA1*01:01 (OR = 0.04; 95% CI = 0.00–0.31); DQA1*01:02 (OR = 0.03; 95% CI = 0.00–0.23); DQB1*02:02 (OR = 0.12; 95% CI = 0.03–0.42) alleles was lower in sepsis patients than in control subjects. The most frequent HLA-DRB1/DQA1/DQB1 haplotypes that was significantly increased in patients with sepsis were: DRB1*01:01/DQA1*05:01/DQB1*03:01 (OR = 12.6; 95% CI = 1.51–105.0; p < 0.003). Sepsis patients with pneumonia and alleles and DRB1 04:01; 07:01, DQB1 02:01 had the highest mortality rate. Undoubtedly, our preliminary data showed that development of sepsis can be associated with alleles and haplotypes of HLA class II genes. For more precise conclusion the research should be continued to include a larger patient group.
Ultrastructural Changes of Organelles in Root Cap Cells of Tobacco Under Salinity
Authors: Baranova Ekaterina N. , Chaban Inna A. , Kononenko Neonila V. , Gulevich Alexander A. , Kurenina Ludmila V. , Smirnova Elena A.
Published: February 2019

We investigated how an abiotic factor, i.e. salinity, affects specific intracellular organelles of cells of the root cap. We focused on: 1) amyloplasts, which are specific plastids of the cap that perform important metabolic and sensory functions; and 2) mitochondria, which protect cells from ROS damage by changing their ultrastructure. In our work we studied the ultrastructural changes of these organelles in different areas of the root cap under NaCl and Na2SO4 impact. We showed that the amyloplasts (statoliths) and mitochondria of the columella and the peripheral zone of the cap change their structural organisation in the presence of NaCl. Under action of Na2SO4, in plastids of columella the number of starch grains decreases dramatically, the cells of the peripheral part of the cap do not contain the amyloplasts, and the proplastids that do not store or store a little starch grains, which is attributed to leucoplasts with typical lamellae characteristic for root cortex cells. Thus, Na2SO4 influence has the most significant effect on the plastids of the root cap, and plastids of the cells of the peripheral zone of the cap are subjected to the most significant changes under salinity stress.
Role and Room for Social Broadcaster With Radio Fara as an Example
Authors: Wilk Dorota
Published: February 2019

The broadcaster, who uses the possibility of functioning in the broadcasting media space as asocial broadcaster, ensures not only independence from power centres, political parties and com-mercial entities, but also full control over the broadcast content. He consciously directs ithe messageto a specific group of recipients, often a niche group, providing content that commercial and publicstations avoid, considering it to be unattractive. The type of programmes broadcast is strictly definedby the role it has to fulfil, the requirements set by the legislator for social broadcasters and the pos-sibilities resulting from having such status. This has a significant impact on the place it occupies inthe media radio market.
Impact of Indian Drama Serials on Bangladeshi Culture: A Qualitative Study Based on Perceived Situation and Risk Factors in Urban Setting
Authors: Razu Shaharior Rahman
Published: February 2019

This study investigates how Indian TV serials are affecting Bangladeshi culture through chang-es in lifestyle, family and intimate relationship, and forms of art and literature. The qualitative re-search was conducted on 60 respondents from Khulna and Dhaka city of Bangladesh who were se-lected through purposive sampling method. Findings suggest that Indian TV serials have a significantimpact on the day-to-day life of people living in Bangladesh. It influences the lifestyle of people asthey spend a considerable time watching these TV serials. Alongside, the indigenous art, literature,language, customs and rituals are being shaped due to heavy dependency on Indian TV serials. Suchinclination raises concern for some potential risks including family conflicts, crime, psychologicaldisorder and even suicide.
Using the New Media by Companies From the Sme Sector in Podkarpackie Province
Authors: Masłyk Justyna
Published: February 2019

The main purpose of this article is to present the results of research concerning the use ofsocial media by companies from the SME sector in Podkarpackie Province. The article includes dataobtained in the first stage of the study, which is a part of a research project on the use of social mediain the area of creating the image of an organization / company as an employer.The survey coveredthe entire population of companies from the SME sector, which are registered in Podkarpackie Prov-ince (REGON database). The research phase, the results of which are presented in this article, mainlyinvolved the analysis of data on companies from the SME sector in Podkarpackie Province in termsof their presence on the Internet (having an individual website, having company profiles on selectedsocial networks).The results of the first stage of the study confirm that the companies see the potential of theonline presence / functioning in social media (more and more companies have their own website,Facebook profiles). The dynamics of changes in this area is definitely not adequate to the pace ofnew media development. On the basis of preliminary results of further stages of the research, it canalso be concluded that in the vast majority of cases, however, these are non-strategic and non-sys-tematic activities.
Giant Basal Cell Carcinoma – a Case Report
Authors: Kapetanović Igor , Reljić Vesna , Bosić Martina , Popadić Svetlana
Published: February 2019

Basal cell carcinoma is the most common form of cutaneous cancer. In majority of cases it is locally invasive with slow growth, ranging in size from a couple of milimeters to a couple of centimeters and located primarily on sun-exposed regions. Giant basal cell carcinoma, defined as a tumor that is larger than 5 cm in diameter, is a very rare type of cutaneous malignancy accounting for 0.5-1% of all basal cell carcinomas. We present a case of a 74-year-old man with a 17 x 14 cm giant basal cell carcinoma in the right supraclavicular region. Detailed history revealed that the lesion had started as a papule 15 years before presentation. Despite its growth, the lesion was neglected until admission. Histological examination of skin lesion confirmed superficial and focally infiltrative types of basal cell carcinoma. Electron radiotherapy was administered with 54 Gy total dose delivered in 20 daily fractions which resulted in healing of lesions and adequate response. Thus, definitive radiotherapy can be just as effective as excision when the criteria are met.
Genotyping of Mycobacterium leprae in a Son-and-Father Pair of Patients Indicated the Possible Mode of Leprosy Transmission: a Case Report
Authors: Gunawan Hendra , Fakhrosa Irma , Saraswati Nia Ayu , Sasmojo Muljaningsih , Hindritiani Reti , Suwarsa Oki
Published: February 2019

One of the success indicators of the World Health Organization (WHO) leprosy eradication program is the decreasing number of new cases of pediatric leprosy with a grade 2 disability. A case of borderline lepromatous (BL) leprosy with partial claw hand in a 13-year-old boy was reported. On physical examination, we found claw fingers on the fourth and fifth fingers of the left hand accompanied by hypoesthetic erythematous plaques on both cheeks. The patient also presented with the enlargement of bilateral great auricular, ulnar, and peroneal nerves. The bacteriological examination showed the bacterial index 3+ and morphological index 35%. The results of histopathological and serological anti-phenolic glycolipid-I examinations supported the diagnosis of BL type of leprosy. Genotyping of Mycobacterium leprae by variable number tandem repeat of the patient showed 24 copies thymine-thymine-cytosine that were similar to his father, who had been diagnosed with leprosy 12 years before, without adequate therapy. The result indicated the possibility of leprosy transmission from the father to a son. This case report revealed the presence of leprosy in children with a multibacillary infection who have been living with leprosy family members. Genotyping seems to be feasible for epidemiological analysis of leprosy transmission.
SURVIVE: let the dead help the living—an autopsy-based cohort study for mapping risk markers of death among those with severe mental illnesses
Authors: Banner Jytte , Høyer Christian Bjerre , Christensen Martin Roest , Gheorghe Alexandra , Bugge Anne , Ottesen Gyda Lolk , Boel Lene Warner Thorup , Thomsen Jørgen Lange , Kruckow Line , Jacobsen Christina
Published: February 2019

Background: Forensic autopsy strategies may improve differential diagnostics both post-mortem and ante-mortem and aid in clinical settings concerning preventive efforts for premature mortality. Excess mortality and reduced life expectancy affect persons with severe mental illnesses (SMI) for multi-faceted reasons that remain controversial. Somatic conditions, medical treatment and lifestyle diseases, which are primarily examined in the living, contribute to premature deaths. The underlying pathophysiological mechanisms are unclear, though, and the benefits of a focused, standardised autopsy remain unproven. We have developed and implemented an optimised molecular–biological autopsy for deceased persons with SMI. Our aim is to map the occurrence of 1) somatic diseases and organ changes; 2) metabolic syndrome; 3) use and abuse of alcohol, pharmaceuticals and psychoactive substances; 4) pharmacokinetic and pharmacodynamic factors in the metabolism of pharmaceuticals; and 5) genetic variations (acquired and/or congenital) in sudden cardiac death. Additionally, we hope to contribute to diagnostic treatments and preventive measures to benefit those living with SMI. Methods: SURVIVE: let the dead help the living is a prospective, autopsy-based study on 500 deceased persons with SMI subjected to forensic autopsies under the Danish Act on Forensic Inquests and Autopsy. The autopsies followed an extended, standardised autopsy protocol comprised of whole-body computed tomography scanning, magnetic resonance imaging of the heart and brain and an extended forensic autopsy, including a wide panel of analyses (toxicology, microbiology, genetics, histology and biochemical analysis). Additionally, post-mortem data were linked to ante-mortem health data extracted from Danish national health registers.

Discussion: The SURVIVE autopsy procedure, including tissue sampling and bio banking, has been shown to be effective. We expect that the SURVIVE study will provide unique opportunities to unravel the mechanisms and causes of premature death in persons with SMI. We also expect that identifying prognostic biomarkers for comorbidities will contribute to prevention of premature deaths and comorbidities in persons with SMI.
Helminths of Exotic Even-Toed Ungulates (Artiodactyla) in the Askania-Nova Biosphere Reserve, Ukraine
Authors: Zvegintsova N. S. , Kharchenko V. A. , Kuzmina T. A.
Published: February 2019

More than 30 species of exotic ungulates are currently kept in the Askania-Nova Biosphere Reserve (Kherson Region, Ukraine). During the years 1978–2014, 146 ungulates of 24 species (16 species of Bovidae, 4 — Cervidae, 4 — Camelidae) were examined by partial helminthological dissection; more than 402,700 specimens of helminths were collected and identified. The purpose of the present study was to summarize these data and analyze the species diversity in exotic ungulates. Totally, 38 species of helminths: 3 species of Trematoda, 6 — Cestoda, 29 — Nematoda were found. Ungulates from the family Bovidae were the most infected; they harbored 36 species of helminths, 1–18 species per host. In Camelidae, 15 species were found; 3–10 species per host. Cervidae harbored 9 species; 1–6 species per host. The highest species diversity was detected in the ungulates introduced from regions with climatic conditions similar to those in southern Ukraine: saiga antelope (19 species), European mouflon (18), Barbary sheep (18), and markhor (17). Ten species typical for domestic ruminants (Haemonchus contortus, Nematodirus sp., Aonchotheca bovis, Moniezia expansa, Oesophagostomum venulosum, Ostertagia circumcincta, Trichostrongylus axei, T. colubriformis, T. probolurus and Trichuris ovis) dominated in the parasite communities. Our results indicated reduction in the species diversity and alteration of the parasite community structures in these exotic ungulates kept in the Askania-Nova Reserve compared to their natural habitats.
EDUCAÇÃO NAO ESCOLAR. ESTRATÉGIAS PEDAGÓGICAS ALTERNATIVAS.
Authors: Zucchetti Dinora Tereza , Moura Eliana Perez Gonçalves de , Lacerda Miriam Pires de
Published: February 2019

A temática da educação no campo social tratada neste artigo, em um sentido amplo, advém de análises de pesquisas sobre experiências produzidas no interior de projetos socioeducativos e cuja a metodologia das investigações é qualitativa, de tipo descritiva com característica longitudinal.  Neste artigo defendemos que práticas de educação não escolar constituem estratégias pedagógicas alternativas que, em certa medida, enfrentam o processo de exclusão social de crianças, adolescentes e jovens constituindo práticas sociais de produção de novos saberes.  O texto visa ressaltar o caráter central da figura do educador quando se empenha em encontrar formas de interagir e de se deixar transformar pelo Outro. Neste processo apontamos outro modo de educar, enquanto campo de possibilidades, se não como vetor de transformação social como experiência que repercute sobre a educação.Palavras-chave: Educação não escolar. Movimentos pedagógicos alternativos. Educadores sociais.ABSTRACTThe theme of education in the social field comes from research on experiences produced within socio-educational projects and whose qualitative methodology is descriptive and characteristically longitudinal. We argue that non-school education practices are alternative pedagogical strategies that, to a certain extent, face the process of social exclusion of children, adolescents and young people, and constitute social practices for the production of new knowledge. This article aims to emphasize the central character of educators when they strive to find ways of interacting and being transformed by the Other. In this process we point to another way of educating, as a field of possibilities that challenges academic formation as a vector of intensification and social transformation.Keywords: Non-school education. Alternative pedagogical movements. Social educators. Academic education.
CONSTRUCTION OF EQUATIONS OF MOTION OF MULTIBODY SYSTEMS AND COMPUTER MODELING
Authors: Hroncová Darina
Published: February 2019

Urgency of the research. Computer models mean new quality in the knowledge process. Using a computer model, the properties of the subject under investigation can be tested under different operating conditions. By experimenting with a com-puter model, we learn about the modelled object. We can test different machine variants without having to produce and edit prototypes.
Target setting. The development of computer technology has expanded the possibility of solving mathematical models and allowed to gradually automate the calculation of mathematical model equations. It is necessary to insert appropriate inputs of the mathematical model and monitor and evaluate the output results through the computer output device The target was to describe the mathematical apparatus required for mathematical modeling and subsequently to compile a model for computer modeling.
Actual scientific researches and issues analysis. When formulating a mathematical model for a computer, the laws and the theory we use are always valid under more or less idealized conditions, and operate with fictitious concepts such as, material point, ideal gas, intangible spring, and the like. However, with these simplifications, we describe a realistic phenomenon where the initial assumptions are only met to a certain extent. In order for the results not to be different from the modeled reality, it is to be assumed that a good computer model arises gradually, by verifying and modifying it, which is one of the advantages of MSC Adams.
Uninvestigated parts of general matters defining. The question of building a real manipulator model. Based on the above simulation, it is possible to build a real model.
The research objective. Using MSC Adams to simulate multiple body systems and verify its suitability for simulating ma-nipulator and robot models. In various versions of the assembled model we can monitor its behavior under different operating conditions.
The statement of basic materials. In computer simulation, MSC Adams-View is used to simulate mechanical systems. It has an interactive environment for automated dynamic analysis of parameterized mechanical systems with an arbitrary struc-ture of rigid and flexible bodies with geometric or force joints, in which act gravity, inertia, experimentally designed contact, friction, aerodynamic, hydrodynamic or electromechanical forces and have integrated control, hydraulic, pneumatic or elec-tromechanical circuits.
Conclusions. Working with a mathematical model on a computer opens space for specific synthesis of empirical and ana-lytical method of scientific knowledge. Working with the computer model carries the characteristic features of classical experi-mentation. It represents a qualitatively new way of solving tasks that can not be experimented with on a real object. The result is the equivalence of the computer model and the object being investigated with the features and expressions chosen as essen-tial, with accuracy sufficient to the exact purpose.
Synthesis, Characterization, and Post-Synthetic Modification of a Micro/Mesoporous Zirconium-Tricarboxylate Metal-Organic Framework: Towards the Addition of Acid Active Sites
Authors: Ardila-Suárez Carolina , Díaz-Lasprilla Ana María , Díaz Vaca Laura Alejandra , Balbuena Perla B , Baldovino Medrano Víctor Gabriel , Ramírez-Caballero Gustavo E
Published: February 2019

Zr-MOFs are characterized by their high thermal and chemical stability which may facilitate their application in heterogeneous catalysis. However, these well-known microporous materials could see restricted their applications in heterogeneous catalysis if large reactants exceed their pore sizes leading to unavailable surface areas. In this work, we studied the effect of acetic acid concentration, used as the modulator, on the formation of micro/mesoporous materials. This inclusion of a modulator during synthesis and its removal by activation process generate materials with missing linker defects. We showed that an increase in the concentration of modulator leads to an improvement of calculated apparent surface area and a modification of MOF-808 pore structure by producing mesopores at the expense of micropores. Furthermore, we performed a post-synthetic modification of the MOF-808. We observed the expected sulfation of the zirconium oxo-cluster but also the sulfonation of the organic ligand. Also, we found that only the families of mesopores and the larger micropores are interconnected within the material, and the ultramicropores seems to be isolated from the porous structure. The PSM process led to the addition of Lewis and Brønsted acid sites to the MOF-808. Experimental results were complemented by theoretical calculations using Density Functional Theory (DFT) and Ab Initio Molecular Dynamics (AIMD) simulations. The rationalization of the synthesis conditions effect and the post-synthetic sulfation process on final properties presented in this paper can serve as a basis for engineering of defects towards the synthesis of solid acid catalysts from MOF 808.
Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction
Authors: Lipp Benjamin , Kammer Lisa Marie , Kucukdisli Murat , Luque Adriana , Kühlborn Jonas , Pusch Stefan , Matulevičiūtė Gita , Schollmeyer Dieter , Šačkus Algirdas , Opatz Till
Published: February 2019

Simultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox-catalyzed three-component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene-functionalized biomolecules. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination.
From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1(MCL1)
Authors: Papatzimas James , Gorobets Evgueni , Maity Ranjan , Muniyat Mir Ishruna , MacCallum Justin L. , Neri Paola , Bahlis Nizar J. , Derksen Darren
Published: February 2019

Here we show the development of heterobifunctional small molecules capable of selectively targeting MCL1 using a Proteolysis Targeting Chimera (PROTAC) methodology leading to successful degradation. We have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon (CRBN) ubiquitination pathway, making these PROTACs a first step toward a new class of anti-apoptotic BCL-2 family protein degraders.
Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid-beta M1-42
Authors: Prakash Priya , Lantz Travis , Jethava Krupal P. , Chopra Gaurav
Published: February 2019

Amyloid plaques found in the brains of Alzheimer’s disease (AD) patients primarily consists of amyloid beta 1-42 (Ab42). Commercially, Ab42 is synthetized using peptide synthesizers. We describe a robust methodology for expression of recombinant human Ab(M1-42) in Rosetta(DE3)pLysS and BL21(DE3)pLysS competent E. coli with refined and rapid analytical purification techniques. The peptide is isolated and purified from the transformed cells using an optimized set-up for reverse-phase HPLC protocol, using commonly available C18 columns, yielding high amounts of peptide (~15-20 mg per 1 L culture) in a short time. The recombinant Ab(M1-42) forms characteristic aggregates similar to synthetic Ab42 aggregates as verified by western blots and atomic force microscopy to warrant future biological use. Our rapid, refined, and robust technique to purify human Ab(M1-42) can be used to synthesize chemical probes for several downstream in vitro and in vivo assays to facilitate AD research.