bluuebunny/crossref_metadata_2025 huggingface dataset:
An Andrographolide from Helichrysum caespitium (DC.) Sond. Ex Harv., (Asteraceae) and Its Antimicrobial, Antiquorum Sensing, and Antibiofilm Potentials
Authors: Bassey Kokoette , Mamabolo Patience , Cosa Sekelwa
Published: November 2021

Helichrysum caespititium (DC.) Sond. Ex Harv., (Asteraceae) is a medicinal plant indigenous to South Africa. Its non-polar extracts exhibit significant antimicrobial and, in particular, antigonorrheal activity. This study aimed at isolating and purifying the active antigonorrheal compound from its chloroform extract and validating its inhibition potential on quorum sensing (QS) and biofilm formation of multi-drug resistant (MDR) pathogens. Phytochemical investigation of aerial parts of H. caespititium afforded a diterpene lactone (CF6). The effect of CF6 on violacein production and biofilm formation was studied using in vitro quantitative violacein inhibition (Chromobacterium violaceum) and biofilm formation (Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Neisseria gonorrhoeae, and Pseudomonas aeruginosa). The structure of CF6 was characterized using FTIR, NMR, and UPLC-MS data accordingly, as 10-methyl-8-(propan-17-ylidene)naphthalen-9-yl)-11-vinyl-14-hydroxyfuran-16-one. The susceptibility testing of the pathogens against CF6 revealed Neisseria gonorrhoeae was noticeably susceptible with a MIC value of 60 µg/mL, while Streptococcus pyogenes and Staphylococcus aureus showed MIC of 125 µg/mL. All gram-negative pathogens, Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa were inhibited at 250 µg/mL. CF6 also inhibited the production of violacein by 51.88% at 250 µg/mL and prevented cell attachment by 40.76–81.18%, with N. gonorrhoeae being highly prohibited from forming biofilm. In conclusion, 10-methyl-8-(propan-17-ylidene)naphthalen-9-yl)-11-vinyl-14-hydroxyfuran-16-one is the first of its kind to be isolated from the non-polar (chloroform) extract of South African Helichrysum caespititium with antigonorrheal, antimicrobial, antiquorum sensing, and antibiofilm properties. The compound may serve as a drug candidate against MDR pathogens.
Alkaloid Escholidine and Its Interaction with DNA Structures
Authors: Jarošová Petra , Hannig Pavel , Kolková Kateřina , Mazzini Stefania , Táborská Eva , Gargallo Raimundo , Borgonovo Gigliola , Artali Roberto , Táborský Petr
Published: November 2021

Berberine, the most known quaternary protoberberine alkaloid (QPA), has been reported to inhibit the SIK3 protein connected with breast cancer. Berberine also appears to reduce the bcl-2 and XIAP expression-proteins responsible for the inhibition of apoptosis. As some problems in the therapy with berberine arose, we studied the DNA binding properties of escholidine, another QPA alkaloid. CD, fluorescence, and NMR examined models of i-motif and G-quadruplex sequences present in the n-myc gene and the c-kit gene. We provide evidence that escholidine does not induce stabilization of the i-motif sequences, while the interaction with G-quadruplex structures appears to be more significant.
The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs
Authors: Belvedere Raffaella , Morretta Elva , Novizio Nunzia , Morello Silvana , Bruno Olga , Brullo Chiara , Petrella Antonello
Published: November 2021

The pyrazolyl-urea Gege3 molecule has shown interesting antiangiogenic effects in the tumor contest. Here, we have studied the role of this compound as interfering with endothelial cells activation in response to the paracrine effects of annexin A1 (ANXA1), known to be involved in promoting tumor progression. ANXA1 has been analyzed in the extracellular environment once secreted through microvesicles (EVs) by pancreatic cancer (PC) cells. Particularly, Gege3 has been able to notably prevent the effects of Ac2-26, the ANXA1 mimetic peptide, and of PC-derived EVs on endothelial cells motility, angiogenesis, and calcium release. Furthermore, this compound also inhibited the translocation of ANXA1 to the plasma membrane, otherwise induced by the same ANXA1-dependent extracellular stimuli. Moreover, these effects have been mediated by the indirect inhibition of protein kinase Cα (PKCα), which generally promotes the phosphorylation of ANXA1 on serine 27. Indeed, by the subtraction of intracellular calcium levels, the pathway triggered by PKCα underwent a strong inhibition leading to the following impediment to the ANXA1 localization at the plasma membrane, as revealed by confocal and cytofluorimetry analysis. Thus, Gege3 appeared an attractive molecule able to prevent the paracrine effects of PC cells deriving ANXA1 in the tumor microenvironment.
Sex-Specific ADHD-like Behaviour, Altered Metabolic Functions, and Altered EEG Activity in Sialyltransferase ST3GAL5-Deficient Mice
Authors: Strekalova Tatyana , Veniaminova Ekaterina , Svirin Evgeniy , Kopeikina Ekaterina , Veremeyko Tatyana , Yung Amanda W. Y. , Proshin Andrey , Tan Shawn Zheng Kai , Khairuddin Sharafuddin , Lim Lee Wei , Lesch Klaus-Peter , Walitza Susanne , Anthony Daniel C. , Ponomarev Eugene D.
Published: November 2021

A deficiency in GM3-derived gangliosides, resulting from a lack of lactosylceramide-alpha-2,3-sialyltransferase (ST3GAL5), leads to severe neuropathology, including epilepsy and metabolic abnormalities. Disruption of ganglioside production by this enzyme may also have a role in the development of neuropsychiatric disorders. ST3Gal5 knock-out (St3gal5−/−) mice lack a-, b-, and c-series gangliosides, but exhibit no overt neuropathology, possibly owing to the production of compensatory 0-series glycosphingolipids. Here, we sought to investigate the possibility that St3gal5−/− mice might exhibit attention-deficit/hyperactivity disorder (ADHD)-like behaviours. In addition, we evaluated potential metabolic and electroencephalogram (EEG) abnormalities. St3gal5−/− mice were subjected to behavioural testing, glucose tolerance tests, and the levels of expression of brain and peripheral A and B isoforms of the insulin receptor (IR) were measured. We found that St3gal5−/− mice exhibit locomotor hyperactivity, impulsivity, neophobia, and anxiety-like behavior. The genotype also altered blood glucose levels and glucose tolerance. A sex bias was consistently found in relation to body mass and peripheral IR expression. Analysis of the EEG revealed an increase in amplitude in St3gal5−/− mice. Together, St3gal5−/− mice exhibit ADHD-like behaviours, altered metabolic and EEG measures providing a useful platform for better understanding of the contribution of brain gangliosides to ADHD and associated comorbidities.
BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity
Authors: Martins Airton C. , López-Granero Caridad , Ferrer Beatriz , Tinkov Alexey A. , Skalny Anatoly V. , Paoliello Monica M. B. , Aschner Michael
Published: November 2021

BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.
Scarring Alopecias: Pathology and an Update on Digital Developments
Authors: Cummins Donna M. , Chaudhry Iskander H. , Harries Matthew
Published: November 2021

Primary cicatricial alopecias (PCA) represent a challenging group of disorders that result in irreversible hair loss from the destruction and fibrosis of hair follicles. Scalp skin biopsies are considered essential in investigating these conditions. Unfortunately, the recognised complexity of histopathologic interpretation is compounded by inadequate sampling and inappropriate laboratory processing. By sharing our successes in developing the communication pathway between the clinician, laboratory and histopathologist, we hope to mitigate some of the difficulties that can arise in managing these conditions. We provide insight from clinical and pathology practice into how diagnoses are derived and the key histological features observed across the most common PCAs seen in practice. Additionally, we highlight the opportunities that have emerged with advances in digital pathology and how these technologies may be used to develop clinicopathological relationships, improve working practices, enhance remote learning, reduce inefficiencies, optimise diagnostic yield, and harness the potential of artificial intelligence (AI).
Abstract Action Language Processing in Eleven-Year-Old Children: Influence of Upper Limb Movement on Sentence Comprehension
Authors: Balduin-Philipps Larissa S. , Weiss Sabine , Schaller Franziska , Müller Horst M.
Published: November 2021

Regarding the embodiment of language processing in adults, there is evidence of a close connection between sensorimotor brain areas and brain areas relevant to the processing of action verbs. This thesis is hotly debated and has therefore been thoroughly studied in adults. However, there are still questions concerning its development in children. The present study deals with the processing of action verbs in concrete and abstract sentences in 60 eleven-year-olds using a decision time paradigm. Sixty-five children mirrored arm movements or sat still and rated the semantic plausibility of sentences. The data of the current study suggest that eleven-year-olds are likely to misunderstand the meaning of action verbs in abstract contexts. Their decision times were faster and their error rates for action verbs in concrete sentences were lower. However, the gender of the children had a significant influence on the decision time and the number of errors, especially when processing abstract sentences. Females were more likely to benefit from an arm movement before the decision, while males were better if they sat still beforehand. Overall, children made quite a few errors when assessing the plausibility of sentences, but the female participants more often gave plausibility assessments that deviated from our expectations, especially when processing abstract sentences. It can be assumed that the embodiment of language processing plays some role in 11-year-old children, but is not yet as mature as it is in adults. Especially with regard to the processing of abstract language, the embodied system still has to change and mature in the course of child development.
Local Retrofit of Reinforced Concrete Structures by the ACM System
Authors: Sorace Stefano , Terenzi Gloria , Fuso Elena
Published: November 2021

During the last decades, low architectural impact strategies have been increasingly adopted in the seismic retrofit of reinforced concrete structures. Among the emerging technologies in this field, the active lateral confinement of columns, beams, and beam-to-column joints is gaining growing attention thanks to the localization of the interventions only on the members in unsafe conditions, the resulting small increase in size, and the limited demolition required for installation. The study presented herein is focused on the application of a highly performing confinement technology, named as ACM (Active Confinement of Masonry), which was conceived more than twenty years ago in Italy for masonry structures, and then successfully applied to reinforced concrete ones. A representative case study is examined in detail herein, i.e., a school built in the early 1960s in the Friuli Venezia Giulia area in Italy. A seismic assessment analysis of the building is carried out in its current state, also supported by preliminary diagnostic investigations, which highlights several seismic deficiencies, especially in terms of shear response of columns and beams. Thus, a retrofit hypothesis based on the installation of the ACM system is proposed, which allows attaining a substantial improvement in the seismic response capacities, while maintaining limited architectural intrusion. A detailed description of the case study characteristics and a synthesis of the time-history seismic analyses developed in original conditions are presented in this article, along with the design criteria, drawings of the interventions, and an evaluation of the resulting performance enhancement in retrofitted configuration.
Renal Safety Profile of EGFR Targeted Therapies: A Study from VigiBase® the WHO Global Database of Individual Case Safety Reports
Authors: Crosnier Alexandre , Abbara Chadi , Cellier Morgane , Lagarce Laurence , Babin Marina , Bourneau-Martin Delphine , Briet Marie
Published: November 2021

Kidney EGFR expression together with reported cases of glomerular diseases in the context of anti-EGFR drug administration raise concerns about the renal safety profile of these drugs. This issue is addressed in a case/non-case study carried out on VigiBase®, the WHO global database of individual case safety reports (ICRS). Disproportionality analysis of renal adverse effects related to the selected anti-EGFR drugs, erlotinib, gefitinib, afatinib, osimertinib, cetuximab and panitumumab, was assessed using the reporting odds ratio (ROR). Nine hundred and eighty-nine ICRSs were included. A signal of disproportionate reporting (SDR) was found for afatinib (ROR = 2.70; 95% CI [2.22–3.29]) and erlotinib (ROR = 1.73; 95% CI [1.46–2.04]) with acute kidney injury, and for afatinib (ROR = 2.41; 95% CI [1.78–3.27]), cetuximab (ROR = 1.42; 95% CI [1.14–1.78]) and erlotinib (ROR = 2.23; 95% CI [1.80–2.77]) with renal failure. The preferred term “diarrhoea” was frequently reported in the included cases. An SDR was found for erlotinib with haemolytic and uremic syndrome (ROR = 4.01; 95% CI [1.80–8.94]) and thrombotic microangiopathy (ROR = 4.94; 95% CI [2.80–8.72]). No SDR was seen for glomerular or tubule-interstitial diseases. This study showed that the anti-EGFR drug renal toxicity is mainly related to renal failure in the context of digestive toxicity.
A Novel Prognostic Biomarker Panel for Early-Stage Colon Carcinoma
Authors: Azcue Pablo , Guerrero Setas David , Encío Ignacio , Ibáñez-Beroiz Berta , Mercado María , Vera Ruth , Gómez-Dorronsoro María Luisa
Published: November 2021

Molecular characterization of colorectal cancer has helped us understand better the biology of the disease. However, previous efforts have yet to provide significant clinical value in order to be integrated into clinical practice for patients with early-stage colon cancer (CC). The purpose of this study was to assess PD-L1, GLUT-1, e-cadherin, MUC2, CDX2, and microsatellite instability (dMMR) and to propose a risk-panel with prognostic capabilities. Biomarkers were immunohistochemically assessed through tissue microarrays in a cohort of 144 patients with stage II/III colon cancer. A biomarker panel consisting of PD-L1, GLUT-1, dMMR, and potentially CDX2 was constructed that divided patients into low, medium, and high risk of overall survival or disease-free survival (DFS) in equally sized groups. Compared with low-risk patients, medium-risk patients have almost twice the risk of death (HR = 2.10 (0.99–4.46), p = 0.054), while high-risk patients have almost four times the risk (HR = 3.79 (1.77–8.11), p = 0.001). The multivariate goodness of fit was 0.756 and was correlated with Kaplan–Meier curves (p = 0.002). Consistent results were found for DFS. This study provides a critical basis for the future development of an immunohistochemical assessment capable of discerning early-stage CC patients as a function of their prognosis. This tool may aid with treatment personalization in daily clinical practice and improve survival outcomes.
Reduction in Standard Cancer Screening in 2020 throughout the U.S.
Authors: Dennis Leslie K. , Hsu Chiu-Hsieh , Arrington Amanda K.
Published: November 2021

Cancer screening is an important way to reduce the burden of cancer. The COVID-19 pandemic created delays in screening with the potential to increase cancer disparities in the United States (U.S.). Data from the 2014–2020 Behavioral Risk Factor Surveillance System (BRFSS) survey were analyzed to estimate the percentages of adults who reported cancer screening in the last 12 months consistent with the U.S. Preventive Services Task Force (USPSTF) recommendation for cervical (ages 21–65), breast (ages 50–74), and colorectal cancer (ages 50–75) prior to the pandemic. Cancer screening percentages for 2020 (April–December excluding January–March) were compared to screening percentages for 2014–2019 to begin to look at the impact of the COVID-19 pandemic. Screening percentages for 2020 were decreased from those for 2014–2019 including several underserved racial groups. Decreases in mammography and colonoscopy or sigmoidoscopy were higher among American Indian/Alaskan Natives, Hispanics, and multiracial participants, but decreases in pap test were also highest among Hispanics, Whites, Asians, and African-Americans/Blacks. Decreases in mammograms among women ages 40–49 were also seen. As the 2020 comparison is conservative, the 2021 decreases in cancer screening are expected to be much greater and are likely to increase cancer disparities substantially.
A Ubiquitous Clinic Recommendation System Using the Modified Mixed-Binary Nonlinear Programming-Feedforward Neural Network Approach
Authors: Lin Yu-Cheng , Chen Toly
Published: November 2021

Most of the existing ubiquitous clinic recommendation (UCR) systems adopt linear mechanisms to aggregate the attribute-level performances of a clinic to evaluate the overall performance. However, such linear mechanisms may not be able to explain the choices of all patients. To solve this problem, the modified mixed binary nonlinear programming (MMBNLP)–feedforward neural network (FNN) approach is proposed in this study. In the proposed methodology, first, the existing MBNLP model is modified to improve the successful recommendation rate using a linear recommendation mechanism. Subsequently, an FNN is constructed to fit the relationship between the attribute-level performances of a clinic and its overall performance, thereby providing possible ways to further enhance the recommendation performance. The results of a regional experiment showed that the MMBNLP–FNN approach improved the successful recommendation rate by 30%.
Os discursos sobre as diferenças na educação: da negação à utopia freiriana da comunhão na escola
Authors: Marques Luciana Pacheco , Gusmão Luka de Carvalho , Jesus Alan Willian de
Published: November 2021

Na Atualidade, ganham cada vez mais corpo as reflexões críticas acerca dos múltiplos modos de exclusão na sociedade, bem como sobre os reais sentidos das políticas de inclusão em diversos espaços de convivência, entre eles o escolar. No presente ensaio, objetivamos dar nossa contribuição a essas reflexões, discutindo os sentidos atribuídos às diferenças humanas no âmbito educacional e ressignificando-os à luz do pensamento de Paulo Freire. Adotando a escrita ensaística, percorremos uma trajetória de pensamento na qual primeiramente destacamos a existência de três diferentes formações ideológicas que caracterizam as atitudes humanas diante das diferenças: a da negação, a da marcação e a da comunhão, sendo que cada uma delas implica num olhar sobre o processo pedagógico. Em seguida, depois de denunciar os discursos da negação e da marcação, desenvolvemos e advogamos em favor da perspectiva da comunhão com as diferenças apoiando-nos nas categorias freirianas de inconclusão, conscientização e diálogo. Por fim, concluímos que a comunhão com as diferenças a partir da leitura freiriana é uma utopia não só possível, como necessária para a concretização de uma educação efetivamente inclusiva.
escola e os movimentos sociais: experiências freireanas na educação fundamental
Authors: Cruz Edilson da Silva , Oliveira Alexandre César Gilsogamo Gomes de
Published: November 2021

Este artigo descreve o projeto “Nós fazemos a História: a escola e os movimentos sociais”, realizado em uma escola municipal de São Paulo entre 2019 e 2020, e o analisa a partir do referencial teórico de Paulo Freire, em especial os conceitos de dialogicidade, problematização e conscientização. O projeto consistiu em receber na escola ativistas de movimentos sociais e populares que militam em diferentes causas (terra, trabalho, direitos de mulheres, povos indígenas, LGBTs, negra etc.) para rodas de diálogo com os estudantes. Tomando como referência as falas dos envolvidos, compiladas em documentário elaborado a respeito, buscamos responder as seguintes questões: em que ambiente escolar idealizou-se o projeto? Como o conhecimento foi construído ao longo do percurso? Quais os resultados alcançados segundo os sujeitos envolvidos? Concluímos que, além de promover aprendizagens significativas, o projeto foi construído a partir da dialogicidade, permitiu a problematização da realidade e despertou consciência crítica, criatividade e capacidade de intervenção no mundo por parte dos educandos. O arcabouço teórico freireano, mobilizado para compreender esta prática escolar, mostra-se pertinente como ferramenta para compreender os processos de transformação e aprimorá-los na escola, contribuindo para construir uma escola pública democrática e emancipatória.
Paulo Freire e o Ensino de Língua Portuguesa em perspectiva
Authors: Ortiz Júlia Mergen , Elias Vanda Maria da Silva
Published: November 2021

O presente artigo tem como tema um estudo sobre o pensamento de Paulo Freire e sua repercussão no e para o ensino de língua. É objetivo da pesquisa refletir sobre como a educação  problematizadora/libertadora de Paulo Freire se faz presente no ensino de Língua Portuguesa orientado por pressupostos de estudos do texto de base sociointeracional. Para alcançar o objetivo descrito, o artigo organiza a reflexão em dois momentos. No primeiro instante, deixa em evidência alguns dos pressupostos da pedagogia de Paulo Freire, como apresentados pelo autor em suas publicações, e por outros estudiosos do pensamento do educador. No segundo instante, amplia o diálogo e promove uma articulação entre o pensamento de Paulo Freire e o pensamento de estudiosos da língua e do texto, que vem servindo de orientação ao ensino de Língua Portuguesa no contexto brasileiro, principalmente a partir de 1980.  No diálogo estreito entre o pensamento de Paulo Freire e o dos linguistas elencados, observa a repercussão e o impacto da pedagogia de Paulo Freire para o ensino de Língua Portuguesa que, compreendendo a língua como forma de ação, visa a promover práticas situadas e significativas de escrita e leitura, por meio da reflexão, da crítica, da problematização e do questionamento por parte dos sujeitos aprendizes, protagonistas desse processo.
Paulo Freire, bell hooks e a construção de uma Pedagogia feminista crítica
Authors: Mariz Silviana Fernandes
Published: November 2021

O presente artigo reflete sobre como bell hooks (1984; 1994) incorporou e transformou o pensamento de Paulo Freire em base teórico­metodológica para a construção e o fortalecimento de uma pedagogia crítica engajada numa perspectiva feminista, antirracista e decolonial. Para tanto, considerando o pensamento freireano como teoria itinerante (SAID, 1983; 2006), realizamos pesquisa em diferentes fontes, bibliográficas e audiovisuais, físicas e virtuais, publicadas principalmente nos Estados Unidos, a fim de estabelecer os marcos de aproximação entre Freire e hooks. Por outro lado, adotamos a prosopografia como método de investigação das características comuns compartilhadas por Freire e hooks em suas trajetórias como intelectuais públicos, situados no campo da Pedagogia Crítica Radical, com a finalidade de identificar conexões e zonas de contato em suas histórias de vida. Com isto, foi possível confirmar a teoria freireana como teoria itinerante, tendo em hooks uma potente leitora e articuladora de sua expansão para os estudos feministas.
Pedagogia(s) da infância, pensamento Freiriano e a busca de um projeto educativo democrático
Authors: Pecoits Sariane da Silva , Kremer Claines , Barbosa Maria Carmen Silveira
Published: November 2021

Este ensaio discute as concepções educativas das Pedagogias da Infância na Educação Infantil (EI) e tem como objetivo articular o pensamento freiriano a essa perspectiva na busca de sustentação de projeto educativo democrático para a primeira infância. A fundamentação teórica que orienta este trabalho tem como base autores da Educação Infantil e os pressupostos teóricos elaborados pelo educador Paulo Freire. O estudo tem como indicativo que as críticas tecidas às Pedagogias da Infância em especial a sugestão de fragilidade pedagógica a ela conferida no que diz respeito à centralidade das crianças e organização do trabalho docente, podem ser reexaminadas a partir desse diálogo. Depreende-se que as concepções de educação e democracia freirianas podem ser valiosos aportes na discussão de processos educativos na EI para sustentação da garantia da participação das crianças em seu processo de aprendizagem.
Estudantes jovens e adultos com deficiência e a prática docente na perspectiva freiriana
Authors: Nogueira Marcela Fontão , Campos Juliane Aparecida de Paula Perez
Published: November 2021

O presente estudo traz como principal questionamento a maneira como professores da sala de aula regular constroem sua prática docente junto aos estudantes jovens e adultos com deficiência. Tem por objetivo analisar as narrativas dos professores sobre sua prática pedagógica, percepções e reflexões sobre a atuação junto a esses estudantes. Trata-se de um estudo de caso realizado em um Centro Integrado de Educação de Jovens e Adultos (CIEJA) no município de São Paulo. Esse estudo contou com a participação de quatorze professores do ensino fundamental I e II. O instrumento utilizado para coleta de dados foi um questionário, e a análise dos dados foi estruturada a partir de ciclos de codificação. Os resultados apresentados indicaram que os professores: flexibilizaram o currículo por meio da reflexão sobre a sua própria prática; foram dialógicos no planejamento e na prática, valorizando os saberes dos educandos; e, finalmente, o fizeram de maneira colaborativa, construindo sua prática docente em parceria com outros professores e com os próprios estudantes.
Aprendendo a sonhar com CIEJA Campo Limpo: a inclusão escolar através de uma metodologia na perspectiva freiriana
Authors: Carvalho Martha Milene Fontenelle , Gueudeville Rosane Santos
Published: November 2021

É necessário pensar as práticas educativas com foco em ações mais humanas, democráticas e equitativas, que ultrapassem os muros ainda resistentes de uma educação bancária e homogênea, que não valoriza a diversidade e liberdade humana. O cenário exige transformação. Diante disso, fazem-se necessárias atitudes que promovam a inclusão educacional, possibilitando que todas as pessoas participem da vida em sociedade, assegurando o acolhimento à diversidade humana e aceitação das diferenças e peculiaridades dos educandos público-alvo da Educação Especial. Assim, o objetivo desta investigação foi compreender as práticas pedagógicas no CIEJA Campo Limpo que dialogam com uma perspectiva freiriana e inclusiva. Tratou-se de um estudo de avaliação do Estado do Conhecimento (ou Estado da Arte). Do ponto de vista do corpus empírico, tratou-se de uma pesquisa documental, alicerçada metodologicamente na Análise de Conteúdo.  Os resultados foram obtidos através do levantamento sistematizado de literatura, realizado por meio do Catalogo de teses e Dissertações da CAPES, através dos descritores: CIEJA e inclusão. Foi encontrado um total de 24 dissertações, utilizando-se como critérios de inclusão estudos que apresentassem como campo empírico o CIEJA Campo Limpo e/ou tivessem a inclusão como eixo de discussão; e como critérios de exclusão, estudos que não tivessem sido realizados no Centro Integrado mencionado. Após a leitura inicial dos respectivos resumos e das descrições metodológicas (em capítulos específicos) apenas 4 (quatro) tratavam diretamente do CIEJA Campo Limpo. Os resultados apontaram que as práticas pedagógicas ancoradas nas concepções freirianas conduzem para a libertação e para uma educação emancipatória e possibilitam pensar o processo de transformação da realidade, tão indispensável ao contexto atual.
Battal Gazi Destanı'nda Kahraman ve Kozmos İlişkisi Üzerine Bir İnceleme
Authors: BAYSAL Nagihan
Published: November 2021

İnsanoğlu varlığının ilk gününden bugüne dek kendini ve çevresini özel hissetmek, kendine özel alan yaratmak ve doğa üzerinde hakimiyet elde edebilmek için yaratıcı güçle arasında bir yakınlık ve bağ kurmak istemiştir. Düzenli ve refah içerisindeki hayatın yaratıcı gücün lütfuyla mümkün olduğu inanması, ilkel dönemlerden günümüze kadar gelmiştir. Bu inanma sonucunda insanoğlunun kutsanma ihtiyacı ortaya çıkmıştır. Bu ihtiyaç nedeniyle kendine kutsal bir alan yaratma çabasında olan insanın meydana getirdiği ben ve öteki kavramları sosyal ve edebi hayat içerisine yerleşmiş ve bütün yaşam bu kavramların üzerine inşa edilmiştir. Makalede ilk olarak ben ve öteki kavramlarından hareketle doğan kaos ve kozmos olgusu açıklanmış, Türk kültüründe ve inanç sisteminde bu kavramların birlikte işleyişine değinilmiştir. Sonraki bölümde Türk kültüründe kahraman kavramı ile bu kavramın yarattığı algı ve kahraman ile kozmos arasındaki bağ ortaya konmuştur. Makalenin ana inceleme kısmında ise Battal Gazi Destanı örnekleminde, bu anlatmada yer alan olaylar üzerinden kahramanın kozmosun yaratılmasındaki rolü ve yeri üzerinde durulmuştur.
Curcumin-mediated photodynamic antimicrobial chemotherapy (PACT): a systematic review / Quimioterapia fotodinâmica antimicrobiana (PACT) mediada por curcumina: uma revisão sistemática
Authors: Silva Eduardo Cândido da , Vasconcelos Ulrich
Published: November 2021

Light energy is known to be used to combat microbial growth. Photodynamic antimicrobial chemotherapy (PACT) has the potential to use different naturally-occurring compounds, such as photosensitizers. Curcumin is an example of a molecule of interest in different areas under different optics. This systematic review surveys the aims and scope of research on curcumin-mediated PACT published between January 2011 and December 2020. The search was carried out in MEDLINE, PubMed, EMBASE and Periódicos CAPES databases employing the keywords “Photodynamic antimicrobial chemotherapy”, “photosensitizer”, “curcumin” and the descriptor “Light-Emitting Diode”. It was observed that in the last decade little material meeting these criteria was published. Brazilian institutions concentrated most of their studies on cytotoxic activity. The most recent work, however, focused on antibiofilm activity. Gram-positive bacteria are more sensitive to curcumin-mediated PACT over a short wavelength range. Different concentrations and exposure time of the photosensitizer were evaluated, but the amount of information is still insufficient to establish the best treatment condition as the number of tested pathogens is still poor.
GREEN AREAS ON THE TERRITORY VORONEZH CITY DISTRICT
Authors: Dunaeva A. , Dedenko Tat'yana
Published: November 2021

The article is devoted to the problem of adverse changes in the environment and the aggravation of environmental problems in megacities. The article deals with the analysis of green areas of the Voronezh city district. Using the method of systematization, generalization and statistical processing, the assessment of the availability of green spaces in the city district is given. The total area of green areas of general use on the territory of the city district of Voronezh is 958.8 hectares. The landscaping area is unevenly distributed across the city districts. The largest area of landscaping falls on the Soviet district, the smallest-on the Leninsky district. The total area of the greened territory of Voronezh and the norms of greening the territory for 1 person still do not correspond to the accepted indicators. The total availability of public green spaces in the city is currently 9.0 m2/person. There is a shortage of comfortable places of recreation for the population in certain administrative districts of the city.
CONDITION OF FIELD PROTECTIVE STRIPS IN CONDITIONS OF STEPPE ZONE OF VORONEZH REGION
Authors: Zamiusskaya E. , Koza V. , Kramareva Tat'yana
Published: November 2021

The paper presents the results of studies of protective strips located in the Voronezh region in the Rossoshansky district. The characteristic of biometric data of forest belts of the same age and their dependence on the density of planting, width of strips and row spacing is given. The comparison of the soil, its impact on the growth and development of trees is displayed. The influence of the design of protective forest stands on the temperature of the surface air layer is also shown. The state of the plantings and the factors that adversely affect it are determined: the lack of care measures, deforestation, clutter and the presence of a large number of diseases and pests.
THE STATE OF THE HERBACEOUS VEGETATION OF THE ROSSOSHANSKY DISTRICT OF THE VORONEZH REGION
Authors: Zamiusskaya E. , Koza V. , Tolbina I.
Published: November 2021

This article presents information about the state of the herbaceous vegetation of the Rossoshansky district of the Voronezh Region. The studies were conducted on 2 trial sites. For this purpose, the eye — measuring method of ground cover accounting was used- accounting for the abundance of individual representatives of the ground cover on the Drude scale and on the Zh. Brown-Blanquet scale. Thanks to this, it was possible to identify plant species that predominate in this area, and species that occur only in a single instance.
ASSESSMENT OF THE CONDITION OF PINE PLANTATIONS ALONG URBAN ROADS OF VORONEZH CITY
Authors: Lykov Igor' , Matveev Sergey
Published: November 2021

We have studied the state of pine phytocenoses in the city of Voronezh, along highways with different traffic intensities. A general degradation in the state of forest stands, a decrease in productivity, damage to radial growth were established. At a distance of 25-30 m from the highways, there is a decrease in the density and stock of forest stands at both sites, due to a decrease in lateral illumination, while the intensity of pollution decreases slightly. At a distance of 185-195 m from the highway at both sites, the height and growing stock reach their maximum values. Density and average diameter vary in different directions due to the presence of a concomitant recreational impact at the ―Prigorodnoye lesnichestvo‖ facility.
FEATURES OF GROWTH OF PETIOLATE OAK IN ARTIFICIAL LINEAR PLANTINGS OF THE CENTRAL FOREST-STEPPE
Authors: Mihina Viktoriya , Kharchenko Nikolay
Published: November 2021

The formation of artificial linear plantations with the participation of pedunculate oak is predetermined by agrotechnical and silvicultural methods of cultivation. Its share among the used other breeds is about 25%. At the age of 33, with the placement of planting places 5.0 x 3.0 m, the pedunculate oak has a high preservation (by 33.9%) in a three-row plantation, in relation to crops from four rows. The protective height in a narrower artificial linear plantation is 10.2 m, which is 1.24 times higher with a width of 20.0 m. In mixed oak-ash crops at the age of 45 years, the best growth and preservation of pedunculate oak is noted in relation to oak plantations pure in composition. For birch-oak crops, the influence of a fast-growing breed is characteristic. At the age of 54, the safety of pedunculate oak is 23.1%, the wind protection height is 19.1 m. Differences in the growth of species are one class of bonitet. In the central rows of pedunculate oak at the age of 30-49 years, the average height has a greater value and a smaller diameter in relation to the indicators of the edging rows (by 7.5-19.9%). A convex transverse profile of the plantation is formed, which is predetermined by the physiological characteristics of the development of the tree species.
INTRODUCTION OF KARELIAN BIRCH TO THE CULTURE IN VITRO
Authors: Isakov Igor , Bokareva Nadezhda
Published: November 2021

At present, the biological diversity of tree species is drying up. One of the main reasons for extinction is the destructive anthropogenic impact. According to the latest data, it became known that the Karelian birch was included in the Red Book of the Republic of Karelia as an endangered and diminishing species. The in vitro clonal micropropagation technology can help to quickly restore the population of Karelian birch. And also the technology under consideration will help to massively produce seedlings and seedlings of Karelian birch for both decorative and silvicultural purposes.
CONSIDERING THE ROLE OF BOTANIC GARDENS AND ARBOTETUM FOR THE DEVELOPMENT OF ECOLOGICAL EDUCATION
Authors: Serebryakov O. , Prokhorova Nadezhda
Published: November 2021

Today, the question of the need for environmental education is of particular importance. It is necessary to restore harmonious ties between man and nature, and this is possible only in contact with the natural environment itself. The irrational use of natural resources, the progressing economic activity of man, which does not take into account the laws of the development of natural systems, lead to a change in natural processes, a violation of the balance of the biosphere. Analysis of various approaches to educational activities in the field of environmental culture revealed the importance of specially protected natural areas in environmental education. They have unique benefits for biodiversity education by providing visual illustrations of the diversity of natural ecosystems.
DISTRIBUTION OF SPECIES OF CYNIPOIDEA IN EARLY AND LATE PHENOFORM QUERCUS ROBUR
Authors: Rad'kova Evgeniya , Popova Anna
Published: November 2021

The object of the study was forest insects that live in the oak forests of Voronezh and the Voronezh region on the Quercus robur of early and late phenological forms. They belong to the order Hymenoptera, the suborder Apocrita, and the subfamily Cynipoidae. The analysis of the presence of various types of Cynipoidae and their association with a certain PHENOFORM in oak stands located directly in the city of Voronezh on Timiryazev and Moskovsky Prospekt streets, in the Shilovo and Zadonye microdistricts, as well as in the Semiluki nursery was carried out. Each type of Cynipoidae causes the formation of only its characteristic galls. Thanks to this, we were able to determine the presence of such types of Cynipoidae: Neuroterus numismalis, Cynips quercusfolii, Andricus inflator, Neuroterus quercusbaccarum. We have identified that the presence of these types of Cynipoidae differ in different oak stands of Voronezh region.
INFLUENCE OF RECREATIONAL LOAD ON ORNITOFAUNA OF THE CITY OF VORONEZH
Authors: Serebryakov O. , Turchaninova E.
Published: November 2021

In this work, we determined the number and systematic affiliation of the most common bird species of the Voronezh upland oak forest in the territories exposed to anthropogenic impact. Field studies were carried out from 2019 to 2020 on the territory of the Voronezh upland oak forest. At the sites selected for the survey, a route counting of birds by voices was carried out. The species composition of the avifauna was supplemented by an analysis of information about the habitat of birds and their nesting sites in areas with constant recreational impact. At the selected sites, birds were counted by voices (mating song). From the results of counts in the studied areas, one can see the diversity of the species composition of the avifauna during the reproductive period. Analysis of the data obtained makes it possible to determine the ecological belonging of the species and compare the quantitative indicators of the birds encountered.
MODERN FLORAL DESIGN IN THE FACE OF CLIMATE CHANGE
Authors: Bakumenko A. , Leontieva E. , Lukina I.
Published: November 2021

This paper substantiates the relevance of using a mix of shrubs and resistant perennials, in particular, cereals and drought-resistant ground cover plants in modern urban flower decoration. An analysis was made of the modern floral decoration of urban social facilities in Voronezh and a search for the current assortment of perennials for mixborders and container compositions. When selecting the assortment, the authors were guided by the ecological requirements of plants and the main purpose of flower beds - to create color dominants of landscape compositions. Particular attention in the work is paid to container gardening. Some of the compositions have already been tested in practice last season on the example of the campus of the Voronezh State Forestry University named after G.F. Morozov. After a year, some adjustments were made to the range of plants. There is an opportunity to extend this experience to other social facilities of the city.
THE CITY AS A SUSTAINABLE ECOSYSTEM
Authors: Bokareva Nadezhda , Dmitrieva A.
Published: November 2021

The city is a multi functional system that combines the entire system of socio-ecological and economic development to fall territorial entities. In this regard, the formation of the principles of sustainable development of the city in modern conditions is one of the most important tasks. The article provides an understanding of the concept of sustainable urban development. The role of environmental planning in achieving sustainable urban development is justified. The principles of urban sustainability management are revealed.
Pengaturan Energy Hybrid Tenaga Surya dan PLN pada Pompa Aerasi Tambak Udang Berbasis PID Control
Authors: Nuryanti Nuryanti , Dwiartomo Bolo , Hikmah Amalia Nur
Published: November 2021

Pengaturan Energy Hybrid Tenaga Surya dan PLN pada Pompa Aerasi Tambak Udang Berbasis PID Control
Pengendalian Tegangan pada Simulator Plant Orde Dua dengan Metode PID Berbasis PLC-HMI WinCC
Authors: Aziz Muhammad Hafiz , Jadmiko Sarjono Wahyu , Yahya Sofian
Published: November 2021

Pengendalian Tegangan pada Simulator Plant Orde Dua dengan Metode PID Berbasis PLC-HMI WinCC
Rancang Bangun Penghitung Jumlah Orang dalam Suatu Ruangan menggunakan Protokol MQTT pada Internet of Things berbasis Raspberry Pi
Authors: Suryatini Fitria , Rifai Afaf Fadhil , Bhaskoro Susetyo Bagas
Published: November 2021

Rancang Bangun Penghitung Jumlah Orang dalam Suatu Ruangan menggunakan Protokol MQTT pada Internet of Things berbasis Raspberry Pi
Perancangan Konsep Sistem Pencampuran FiO2 Pada Mesin GLP HFNC-01 Secara Otomatis dengan Menggunakan Metode Pahl and Beitz
Authors: Rasyiid Refi Amirul , Subardjah Adri Maldi
Published: November 2021

Perancangan Konsep Sistem Pencampuran FiO2 Pada Mesin GLP HFNC-01 Secara Otomatis dengan Menggunakan Metode Pahl and Beitz
MODIFIKASI MEDIA TANAM UNTUK MENINGKATKAN MUTU BIBIT HANDEULEUM (Graptophyllum pictum L. (Griff.)) DARI BEBERAPA MACAM ASAL STEK
Authors: Rahayu Tri , Ihsan Mohamad , Pamujiasih Tri
Published: November 2021

The research titled "Modification of Planting Media to Improve the Quality of Handeuleum (Graptophyllum Pictum L.) Seedling from Several Kinds of Cuttings Source", was conducted in Sukoharjo, Central of Java. The first treatment was the kind of cuttings source, namely: cuttings from the shoot (S1), cuttings from the second section (S2), and cuttings from the third section (S3). The second treatment factor is the kind of media: sandy soil media (M1), rockwool media (M2), and cocopeat media (M3). The data obtained were analyzed by using the F test at 5% and 1% significantly levels, while the follow-up test was carried out using Duncan's multiple range test at the 5% significantly level. The results obtained indicated that the S treatment (kind of cuttings source) had a significant effect on the variables of the number of branches, number of leaves, and leaf area of ​​each seedling. The highest number of branches and leaves was achieved in the S3 treatment (third section cuttings), followed by S2 (second section cuttings) and S1 (shoot cuttings) treatments. There were a significant difference between the treatments. In leaf area variables, the highest yield was achieved at S1 (shoot cuttings), followed by S2 and S3 which were significantly different between each other. Treatment S showed no significant effect on variables the appearance time of the buds, fresh weight of leaves and dry weight of leaves. The treatment of various media had a significant effect on the leaf area variables of each seedling. Cocopeat media (M3) produced the highest leaf area, followed by M1 (sand media), and M2 (rockwool media) treatments. There was no interaction between treatments of kind of cuttings source and types of media for all observed variables.
PERAN REFUGIA SEBAGAI MEDIA KONSERVASI ARTHROPODA DI LAHAN PADI DESA DELIKSUMBER
Authors: Wijayanti Ari , Windriyanti Wiwin , Rahmadhini Noni
Published: November 2021

Rice is basic neet for Indonesia people. East Java experienced decrease rice production 2% in 2014, the problem was insect pest. Insecticides are dangerous that replaced use refugia attracting biological agens. Purpose of the research to discover the role of refugia as conservation medium in suppressing pets attacks and increasing the diversity arthropod populations in rice fields.  This study uses a direct insect sampling method and uses traps such as sweep nets, yellow traps, pitfall traps and light traps. Identification of insects using an introduction to the study insect and iNaturalist. Analysis of the observational data quantitatively by calculating the species diversity index (H’), evenness index (E), Richness index (R) and dominance index (C) then tabulated using excel. observations indicate the number of insects found on land A (rice with refugia) was 5661 individuals consisting of 12 ordo, 61 family and 94 species. Meanwhile on land B (rice without refugia) was 3,198 individuals consisting of 11 ordo, 43 family and 56 species. Refugia affected the population of biological agens more on land A was 2707 individuals than on land B was 1215 individuals. While the pest population on land A much less as 364 individuals than on land B as 763 individuals. Tabulation from the calculation of the species diversity index as 0.142 and 0.118, the species evenness index as 0.030  and 0.025, the dominance index of 0.0004 and 0.0013 is classified as low, while the species richness index of 10.76 and 6.82 is classified as high.
PGPR, PEMUPUKAN AN ORGANIK DAN VERMIKOMPOST TERHADAP PANJANG BATANG & DIAMETER TEBU (Saccharum officinarum L.) DI SCREENHOUSE
Authors: Pitaloka Dyah , Sudiarso Sudiarso , Yudo Triasmoro Setyono , Prayogo Cahyo
Published: November 2021

Combine between fertilizer vermicompos, inorganic fertilizer and PGPR is a breakthrough in the development of agricultural technology to increase the growth of persistent vegetative state and the results of production plant cane.  This researsh aims to determine the effect of a combination of organic fertilizers (vermicompost), inorganic and PGPR on the growth of the length and diameter of plant cane. Vegetative growth studycondukted in screenhouse Brawijaya university poor starts in August 2019 until january 2020. Treatment such as 1). PGPR 5 ml per liter or 10 ml per liter combined with fertilizer inorganic 100% (7 kw ZA + 3 kw SP 36 + 3 kw kcl 2). PGPR 5ml per liter or 10 ml per liter combined with vermikompos 10 ton/ha mixed with 50% inorganic fertilizer the research was compiled using random design comlplete factorial. Repeated three times result showing that the PGPR 10 ml per liter proved to be able to increase long stalks of, the provision of a mixture of fertilizer and inorganic vermikompos 50% able to ancrease growth of plant in the trunk dameter, sugar cane, a combination pgpr and vermikompos mixed inorganic fertilizers able to enlarge the diameter of a plant stem sugar cane.