bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing the Effects of a Herbal Drug based on Echium Amoenum With Fluvoxamine in the Treatment of Adolescents with Obsessive-compulsive Disorder
Authors: Abrishami Maryam Hosseini , Noras Mohamad Reza , Soltanifar Atefeh , Salari Roshanak , Jarahi Lida
Published: June 2022

Background:

Obsessive-compulsive disorder (OCD) is a severe and debilitating neuropsychiatric condition. Although selective serotonin reuptake inhibitors, tricyclic antidepressants, and cognitive- behavioral therapy are the first-line medication and treatment for OCD, an estimated 30% of patients are treatment-resistant, and complete functional recovery is rare. Natural products as adjuvant or alternative therapies should be examined to find safer and more effective ways to manage OCD.

Objective:

To investigate the potential benefits of a combined herbal drug based on Echium amoenum in treating OCD.

Methods:

Design and Setting: In the psychiatric clinics of Mashhad University of Medical Sciences, 40 patients who met the criteria for the obsessive-compulsive disorder based on DSM-5 were studied in a parallel, double-blind, randomized clinical trial.

Intervention:

Subjects were randomly assigned to receive Echium amoenum-Melissa officinalis syrup and fluvoxamine or placebo syrup and fluvoxamine for 8 weeks.

Outcome Measures:

The efficacy of treatment and recurrence of disease were surveyed and compared according to the Yale-Brown Obsessive Compulsive Scale at weeks 0, 4, and 8.

Results:

Evaluation at the 4th and 8th week showed no significant differences between the two groups (p-value = 0.11, p-value = 0.445, respectively). At the 8th week of treatment, patients in the intervention group showed a remarkable reduction in scores on the Yale-Brown Obsessive-Compulsive Scale questionnaire (p- value= 0.003), and patients in the control group didn’t ((p- value= 0.180). This study showed that the E.amoneum-M.officinalis syrup was not significantly more efficacious than the fluvoxamine tablet, but the intervention group showed a significant improving trend (p-value= 0.001).

Conclusion:

While monotherapy is usually the gold standard methodology, combination or augmentation therapy may also be of merit. Consequently, studies with larger sample sizes and the inclusion of para-clinical assessments such as serologic tests can further shed light on the mechanism of action of the E. amoneum- M. officinalis syrup and deepen our understanding of its effects.

Clinical Trial Registration Number:

We registered this trial in the Iranian Registry of Clinical Trials (registration ID: IRCT20191127045521N1).
Beta Thalassemia Carrier Rate: Problem Burden among High School Children
Authors: Sherief Laila M. , El-Shanshory Mohamed R. , Yahia Sohier , Ragab Seham M. , Mansour Ahmed K. , Hassab Hoda M. , Hesham Mervat A. , Ahmed Adel S. , Beshir Mohamed R. , El Fotoh Wafaa M. Abo , El Naby Sameh A. Abd , Alllah Ahmed M. Gad , Khalifa Naglaa A. , Soliman Mohamed A. , El-Dahtory Faeza , El-Farahaty Reham M. , Osman Engy , Elhabyan Abdelazeem , El-Lateef Amal E. Abd , Kamal Naglaa M. , Kabbash Ibrahim A. , Saied Shimaa M. , Eid Abdel-Rahman
Published: June 2022

Background & Aim of the work:

β-Thalassemia (βT) is highly prevalent in some countries like Egypt. Accurate data about actual disease prevalence and heavily prevalent geographic locations are essential to help in early detection and in setting up effective preventive programs. We aim for screening of βT carriers among Egyptian high school students in the Delta region.

Subjects and Methods:

A cross-sectional multicenter study was carried on 4320 randomly selected students from four governorates of the Nile Delta region, Egypt. All patients were to be tested for their complete blood count. Those with microcytic hypochromic anemia not caused by iron deficiency were tested for βT carrier status using high-performance liquid chromatography.

Results:

The total prevalence of βT carrier rate was 6.13%. The highest prevalence was detected in Al-Sharkia Governorate, reaching 7.89%, followed by 6.90% in Al-Gharbia Governorate. Al-Dakahilia and Al-Menoufia showed lower rates of 4.86% and 3.73%, respectively.

Conclusions:

Despite the premarital national screening program for βT in Egypt, the carrier rate is still high. More effort should be done for the proper implementation of national prevention programs.
Human Umbilical Cord Mesenchymal Stem Cells' Cultivation and Treatment
of Liver Diseases
Authors: Zhu Zihe , Zhang Qianqian , Liu Lixin , Xu Jun
Published: June 2022

Background:

Over the past few years, mesenchymal stem cells (MSCs) have been regarded as
effective for treating various diseases. Among the types of MSCs, human umbilical cord mesenchymal
stem cells (hUC-MSCs) have been widely studied because of their advantages in non-invasive damage to
donors and the wide range of sources.

Main body:

This article reviews three aspects of hUC-MSCs. Foremost are the latest advances in the
cultivation and preparation methods of hUC-MSCs. Furthermore, the treatments mechanism of hUCMSCs
in organ transplantation and liver diseases. Finally, a summary of their use in clinical trials in liver
diseases. The first part of this paper emphasizes the differences between the selection area and culture
factors, including the separation method, long-term culturing in vitro, medium composition, serum, and
three-dimensional (3D) skeleton system training, which could affect the characteristics of hUC-MSCs and
the treatment of diseases. The second section mainly stresses the mechanisms of hUC-MSCs in the treatment
of diseases, including immunoregulation and transdifferentiation into hepatocyte-like cells. Many
new technologies mark and track cells in vivo and their safety. Briefly mention its role in the treatment of
other diseases and vaccine preparation. In the third part, to accelerate the application of hUC-MSCs in the
treatment of clinical diseases, it is necessary to expand the sample size of clinical trials to ensure their
safety in the human body and determine the most effective infusion method and volume. Conclusion:
hUC-MSCs have a substantial potential to become a more effective treatment for liver diseases. Clinical
trials and mechanisms have laid the foundation for the normalization of clinical hUC-MSCs delivery.
Design, Synthesis and Biological Evaluation of Novel Quinoline Derivatives as Potential
Anti-Proliferative Agents Against PC-3 and KG-1 Cells
Authors: Zhang Wei , Ma Peizhi , Li Kun , Xu Yuanbo , Sun Jun
Published: June 2022

Background:

Cancer is a major public health problem worldwide, and is the leading cause of death.
The discovery and development of cancer therapeutic drugs have become the most urgent measure, which significantly
benefited from the usage of small molecule compounds. The quinoline core possessed a vast number
of biological activities that were found to be imperative.

Objective:

The aim is to design, synthesize and perform the biological evaluation of novel quinoline derivatives
as potential anti-proliferative agents.

Methods:

Quinoline as a privileged scaffold was adopted to introduce diverse effective nitrogen heterocycles
through different linkers. The synthesized compounds were spectroscopically characterized and evaluated for
their anti-proliferative activity using the CCK8 assay. The mechanism of action was investigated by flow cytometry
and the inhibitory activity against Pim-1 kinase was measured by mobility shift assay. Molecular docking
analysis was performed to rationalize biochemical potency as well.

Results:

The majority of these quinolines displayed potent growth inhibitory effects, among which compounds
13e, 13f and 13h were the most effective ones, with GI50 values of 2.61/3.56, 4.73/4.88 and 4.68/2.98 μM, respectively.
Structure-activity relationships indicated that both appropriate heterocycles at the C4 position of pyridine
and suitable substituent at quinoline had a significant impact on improving activity. Compounds 13e and
24d exhibited moderate Pim-1 kinase inhibitory activity.

Conclusion:

In this study, three series of novel molecules bearing quinoline scaffold were designed, synthesized
and evaluated for their in-vitro anti-proliferative activity. The most promising candidate, 13e, caused cell cycle
arrest in a concentration-dependent manner and further induced apoptosis, which might represent a novel antiproliferative
agent working through Pim-1 kinase inhibition to a certain extent.
The Prevalence of Early Toxoplasmosis after Bone Marrow Transplantation
Using PCR: A Study in Iranian Patients
Authors: Abolghasemi Sara , Khederzadeh Sepideh , Salari Sina , Mardani Masoud , ArabMazar Zahra , Ettefaghi Mona , Kamrani Ramiz , Ghorbi Mahmoud Dehghani
Published: June 2022

Background:

In immuno-compromised organ transplant recipients, toxoplasmosis can be
caused by either an infected graft or a latent infection, during which transformation from a chronic
state to an active infection (reactivation) is observed. PCR is an accurate and sensitive molecular
method widely used in medical sciences, especially in diagnostic procedures.

Objective:

The aim of this study was to determine the prevalence of early toxoplasmosis infection in
bone marrow transplant patients by PCR.

Methods:

The blood samples of 50 patients with hematological disorders who had received bone marrow
transplants were collected using a standard phlebotomy technique. To evaluate antitoxoplasma
antibodies, we utilized the enzyme-linked immunosorbent assay (ELISA) method using a specific
commercial kit (Akon) based on the manufacturer’s instructions. Genomic DNA extracted from toxoplasma
tachyzoite was used as the template for PCR.

Results:

22 (44%) patients were women, and 28 (56%) were men. There were no significant differences
in the distribution of genders and age groups in patients with various cancers. Antitoxoplasma
IgG was positive in 39 patients, while none of them were IgM positive.
According to PCR results, 5 patients were positive for toxoplasmosis. All of the PCR-positive cases (2
with AML, 2 with HL, and 1 with AA) had successful engraftment at 40 days post-transplantation.

Conclusion:

Because of the higher efficacy of PCR in the diagnosis of toxoplasmosis, using this method
along with other routine diagnostic modalities in this condition is recommended. PCR-based techniques
can also be utilized to periodically determine parasite load in blood after transplantation.
The Role of Soluble ACE2 as a Prognostic Marker in Severe COVID-19: A
Brief Meta-Analysis
Authors: Rahimzadeh Mahsa , Naderi Nadereh
Published: June 2022

Background:

The recently emerged novel coronavirus, severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), has posed a serious threat to public health, and there is an
urgent need to establish tools that can aid the clinician in the evaluation and management of highrisk
patients. This meta-analysis aimed to investigate the potential of sACE2 (soluble angiotensinconverting
enzyme 2) as a prognostic biomarker in COVID-19.

Method:

A comprehensive search of PubMed/MEDLINE, Cochrane, and Google Scholar, was
performed until May 26, 2021. Data extraction and quality assessment of the study were independently
conducted by the authors. Finally, 6 studies were included in this meta-analysis.

Results:

ACE-2 serum or plasma levels were compared between COVID-19 patients and healthy
controls. ACE-2 level was not significantly different between severe COVID-19 patients and
healthy controls (SMD = 1.2; 95% CI: -1.3-1.5; P = 0.86), severe and non-severe COVID-19 patients
(SMD = 0.3; 95% CI: -0.06-0.7; P = 0.1), and severe COVID-19 patients and healthy controls
(SMD = 0.6; 95% CI: -1.1-2.3; P = 0.5).

Conclusions:

We cautiously propose that circulating levels of ACE2 cannot be used as a biomarker
to assess disease severity in COVID-19 patients.
Preparation and Photocatalytic Properties of Zn Doped Ba Germanate Nanorods
Authors: Pei L. , Liu H. , Lin N. , Wang S. , Yu H. , Nam-Trung Nguyen
Published: June 2022

Zn doped Ba germanate nanorods have been prepared by the hydrothermal process and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and solid UV-vis diffuse reflectance spectroscopy. XRD analysis shows that the Zn doped Ba germanate nanorods consist of hexagonal Ba2Ge5O12 and rhombohedral ZnGeO3 phases. The size and band gap of the Zn doped Ba germanate nanorods depend on the Zn doping mass percentage. The band gap of the 1wt.% Zn doped Ba germanate nanorods is 4.07 eV which is smaller than that of undoped and Zn doped Ba germanate nanorods with the Zn doping mass percentage of 3%, 5% and 10%. The role of the irradiation time and content of the nanorods in aqueous solution has been analyzed. The 1wt.% Zn doped Ba germanate nanorods show the highest photocatalytic activity under UV light irradiation. The photocatalytic activity has been greatly enhanced by the Zn doping.
PENGARUH RASIO PROFITABILITAS DAN RASIO SOLVABILITAS TERHADAP NILAI PERUSAHAAN YANG DIMODERASI OLEH AUDIT DELAY
Authors:   Department of Accounting, Faculty of Economics and Business. Universitas Pendidikan Ganesha, Dewi Luh Gede Kusuma
Published: June 2022

This research aims to identify the effect of profitability ratio (Return on Assets-ROA) and solvency ratio (Debt to Equity Ratio-DER) on the value of a company, and to identify audit delay expertise in moderating the effect of ROA and DER on firm value. The population in this research is a variety of industries listed on the IDX in 2015-2019 totaling 44 listed on the IDX in 2015-2019. The data sampling used is a purposive side method. The dependent variable of this research is the value of the company as measured by Tobins'q. The independent variables of this research are return on assets and debt to equity ratio. The moderating variable for this research is audit delay. The research results show (a) ROA does not af-fect firm value, (b) DER affects firm value, (c) Audit delay strengthens ROA's effect on firm value, and (d) Audit delay weakens DER's effect on firm value.
La ciudad sustentable: una aproximación a su conceptualización
Authors: Castillejos Moguel Daniela Itsabe
Published: June 2022

Para conceptualizar la ciudad sustentable, debemos analizarla desde sus orígenes y su transformación en el tiempo, debido a cambios sociales, económicos y ambientales. A partir de la entrada del capitalismo y la industrialización, se han transformado las ciudades en metrópolis. Esto ocasiona problemas sociales y ambientales, como la generación de contaminación, al igual que la explotación de recursos naturales, y una falta de responsabilidad social ambiental. Por tanto, se presenta la necesidad de tomar estrategias para que se logre integrar los ámbitos económico, social, ambiental y territorial, y, de igual manera, crear una consciencia social para poder preservar a la ciudad de una manera sustentable.
Subjek Pasca Pandemi Covid-19 dalam Perspektif Filsafat Politik Michel Foucault
Authors: Simon Untara , Hendrawan Datu , Yuniarto Antonius
Published: June 2022

Tujuan artikel ini adalah untuk menunjukkan bahwa pada masa pandemi covid 19, berbagai upaya yang dilakukan setiap organisasi sosial untuk menjaga keselamatan warganya menghasilkan berbagai strategi kuasa yang mengatur tindakan individu. Bagi setiap individu, proses politik ini menempatkan kebebasan dalam risiko. Dengan alasan demi keselamatan bersama, tiap orang dikondisikan untuk tidak menjadi subjek yang bereksistensi dan mengejar tujuannya sendiri. Oleh karena itu, artikel ini ingin menjawab pertanyaan dasar soal bagaimana strategi kuasa dijalankan dan mengarahkan tindakan individu pada masa pandemi dan bagaimana individu bisa menjadi subjek yang menentukan diri dan subjektivitasnya. Metode yang digunakan dalam penelitian ini adalah meta-analisis dan hermeneutika dengan menggunakan kerangka teori filsafat politik Michel Foucault. Dalam penelitian ini, peneliti menemukan bahwa dalam masa pandemi covid-19 ini, strategi kuasa terhadap individu dilakukan untuk mencapai tujuan politik komunitas/masyarakat yang dianggap lebih penting daripada tujuan pribadi individual. Situasi ini menantang eksistensi subjektivitas. Meski demikian, belajar dari Foucault, peneliti menemukan bahwa eksistensi subjek tetap bisa dibentuk sekalipun individu berada dalam situasi kontrol politis. Pembentukan subjek ini terjadi jika seseorang mampu menentukan tujuan hidup yang ingin dicapai, memahami hal-hal mendasar dalam hidupnya yang harus diubah untuk mencapai tujuan hidup, menentukan bagaimana ia berelasi dengan hal-hal mendasar serta mampu mempraktekkan teknik atau strategi konkret.
El Tractatus al rescate de Principia Mathematica: Ramsey y los fundamentos logicistas de las matemáticas
Authors: Méndez Pinto Emilio
Published: June 2022

Mi objetivo es discutir las principales dificultades que Frank P. Ramsey encontró en Principia Mathematica y la solución que, vía el Tractatus Logico-Philosophicus, propuso al respecto. Sostengo que las principales dificultades que Ramsey encontró en Principia Mathematica están, todas, relacionadas con que Russell y Whitehead desatendieron la forma lógica de las proposiciones matemáticas, las cuales, según Ramsey, deben ser tautológicas.
The Influence of Operational Settings on the Tensile Strength of an FDM-Printed Abs Component
Authors: Singh Arpit , Anas Mohd
Published: June 2022

Abstract: This paper’s purpose is to investigate tensile strength of FDM-print ABS components. FDM has evolved beyond rapid prototyping to rapid manufacturing in recent years, allowing items manufactured using the FDM process to be used immediately. Poor and anisotropic mechanical qualities, on the other hand, had a substantial influence on the use of fused model manufactured components. By carefully selecting framework, the automated qualities often FDM components can be improved. There will be three parameters on which the research is going through, angle of raster, height of layer, and breadth of raster, were chosen in this work to investigate their impact in the tensile samples. The components are manufactured to the ASTM D638 Type 4 standard. The inflated tensile strength was found with a angle of raster of 0 degrees. Because of the larger bonding surface between the layers, a lower layer height is associated with better tensile strength. The strength of a tensile component improves up to a point when the raster width is increased, after which the existence of void diminishes and tells how strong a material is when it is stretched.
Design and Construction of Vertical Axis Wind Turbine Blades
Authors: Meena Himanshu
Published: June 2022

Abstract: This study aims to check the Vertical Axis Wind Turbines blades and their different types and their feasibility. Increase in energy demand results in need of clean energy like wind energy. This project is done to design and construct the vertical axis wind turbine blade for small scale usage. The vertical axis wind turbine is having axis of rotation vertically and that’s why yaw motor is eliminated. The demand of renwable energy sources is increasing day by day as the fossil fuel is limited and will end one day as well as it has adverse effect in environment and which leads to green house effect, etc
Single Phase Prepaid Smart Energy Meter System Using an RFID AND Arduino Nano
Authors: Gabane Shubham
Published: June 2022

Abstract: In the present day scenario, the energy consumption awareness plays an important role as its demand is growing day by day. Huge differences in energy production and consumption urges the need to reduce the power wastage. The prepaid electricity system proposed in this paper aims at reducing the wastage of power due to its theft and control its usage on the consumer side. This increases the overall efficiency of the power system. The RFID card enables a consumer to utilize the energy for which he has paid. A microcontroller continuously checks if his balance is within the threshold limit and he is notified when his balance goes below the limits. Once it exceeds the threshold value, the supply is automatically cut off. The user can then recharge by making an online payment whenever necessary. The LCD continuously shows the units of energy consumed.
Building Crack Detection Using Deep Learning Techniques
Authors: Maheskumar Mr. V.
Published: June 2022

Abstract: Reliability, performance, and life cycle costs are real concerns for almost all in-service massive structures, such as buildings, bridges, nuclear facilities, hydroelectric structures, and dams. Cracks on these structures are a common phenomenon associated with various internal and external forces, including the corrosion of embedded reinforcement, chemical deterioration of concrete, and the application of adverse loading to the structure. In comparison to the traditional manual inspection-based crack detection system, computer vision and machine learning-based approaches are quickly becoming an integral part of the modern segmentation of civil infrastructures to automate crack detection and identification systems. The project is about the construction and application of a device that uses image processing to detect cracks. The system has a graphical user interface for initializing the device, viewing real time image, taking pictures of a crack, measuring its width, and evaluating if safe or unsafe.
Blockchain, AI & Web3.0 in Metaverse of Madness
Authors: Jadhav Omkar Dinesh
Published: June 2022

Abstract: As our world moves forward we have gone from reading books and papers to scrolling through endless instagram feeds. And the metaverse is exactly what the next-gen social media would look like. Anything that we do in the real world e.g. Hanging out with friends, visiting the art gallery, watching a soccer game can now be done in a living, shared, everlasting virtual world. The impact of artificial intelligence and blockchain technology on the metaverse is discussed in this research paper.
Colour Detecting and Sorting Robot
Authors: Sonavane Ms. Shivani Bhagwan
Published: June 2022

Abstract: In this digital world, color processing in numerous industries gives us more leverage to unravel the consistency problem of continuous manual sorting. This document are a replacement approach to continuously detect and classify objects and keep them in a very specific place. Color processing attracts plenty of attention since the assistance of contemporary technology results in the likelihood of expanding the scope of its application in various areas. The Arduino Nano microcontroller, TCS3200 colour sensor, servo motor, and other electronic components are wont to study, develop, and build a color sorter. This work involves sensors that detect the colour of the item and send the signal to the Arduino. The microcontroller sends a proof to the circuitry that drives the varied motors to activate the thing and place it within the specified location. supported the detection, everything moves to the required position releases the thing, and returns to the first position. The system is in a position to quickly classify the article supported its color at the respective color station. Sorting objects is an essentially mechanical process that needs difficult work. The chronically manual layout ends up in consistency problems. Above all, machines can do boring tasks that humans are superior to. Worker burnout in sequential production structures can result in reduced execution and purpose issues in maintaining the article. Recognize the colour of the article but in no way a machine. during this article, a compact registration near the arrangement of things supported color was implemented using the TCS3200 color sensor with servo motors in conjunction with Arduino Nano.
Detection of Online Employment Scam Through Fake Jobs Using Random Forest Classifier
Authors: Madhavi Dr. D.
Published: June 2022

Abstract: To avoid fraudulent post for job in the internet, an automated tool using machine learning based classification techniques. Different classifiers are used for checking fraudulent post in the web and the results of those classifiers are compared for identifying the best employment scam detection model. It helps in detecting fake job posts form an enormous number of posts. Two major types of classifiers, such as single classifier and ensemble classifiers are considered for fraudulent job posts detection. However, experimental results indicate that ensemble classifiers are the best classification to detect scams over the single classifiers.
Wireless Sensor Networks Master Slave based Farm Monitoring
Authors: Ramaswami T.
Published: June 2022

Abstract: There are many tough situations where in it becomes harder to monitor our farm area manually. To check the water supply and wetness of soil, to detect occurrence of a fire accident, internist of light etc. Sometimes manual inspection may not be very precise, humans generally not intentionally do overlook. So instead of checking out manually we use Wireless Sensor Networks (WSN), that monitor our farm and update data on to the server, which can be monitored by sitting at home. This also helps us in continuous monitoring of our farm without any inconvenience. To achieve this, we are using wireless sensor networks Master Slave model. Where in, both master and slave are equipped with the sensors to measure the environment. Each master and slave are equipped with the smoke sensor, soil moisture sensor, LDR, DTH11 to monitor the surrounding environment. Mater node acts as a gate way i.e, (all) the slave nodes communicate to or transfer information to the master node. Mater node transmits the information on to the server. This communication between slave to master is done using ZigBee HC12 modules and Bluetooth module is used for the communication between master and the server. Here we are using a mobile application, Arduino Bluetooth controller to show the received data.
Indoor Localization for Intrusion Detection and Monitoring RSSI Based
Authors: Baliyan Sudhanshu
Published: June 2022

Abstract: A real time machine for Intrusion detection & monitoring primarily based on wireless sensor network technology is designed by using the use of the mote that's developed & designed in as the communication module inside the network. This dissertation tells tool-free Passive Localization with RSSI. Primary objective of this dissertation is to layout D.F.P Localization that can be redeployable, reconfigurable, smooth to apply, & operates in actual time. The embedded intrusion detection algorithm is designed so that it may cope with the limited assets, in terms of computational energy & available memory area, of the microcontroller unit (MCU) determined inside the nodes & various demanding situations & problem confronted during the real check mattress deployment & additionally proposed solutions to conquer. We come up with an opportunity algorithm primarily work on minimum Euclidean distance classifier the output suggests that localization accuracy of the method is accelerated while usage of the proposed algorithm.
Design of Novel Parking Shed
Authors: Sawarkar Dr. Sameer S.
Published: June 2022

Abstract: This project's essential reason is to produce Novel Parking Shade. A graph that is both budget-friendly and visually appealing. Changing the structural appear of a everyday parking facility with a creative format approach. Make certain there are no misunderstandings and that the whole thing is visible. Pedestrians and vehicles are both safe. It need to be aligned with parking rows that run parallel to the pedestrian crossing and supply handy parking (parking region orientation). The shape carries solely one column, which is supported with the aid of cable and enables for a extra cost effective construction by lowering the variety of columns.
Chatbot Application for Tourism Using Deep Learning
Authors: K R Trisha
Published: June 2022

Abstract—Chatbot is broadly known now a days which is intended to expand the communication and connection with human users. Generally, it works by question from the user and response by a software program. The user can enter the question by means of text. When the user enters the query, the bot uses TensorFlow’s tokenizer to assign a unique token to each distinct word and send it to RNN layer. This chatbot will essentially respond to the queries and relevant information on all the tourist places and facilities in Andaman and Nicobar island.
Of the People, By the People, For the People? Quebec's Bill 60, Representative Bureaucracy, and National Identity-Building
Authors: Lye Matt
Published: June 2022

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Confronting Caligula: Toward an Effective Ethical Infrastructure for Local Governments in Ontario
Authors: Dicker Jacob L.
Published: June 2022

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Celso Sánchez Capdequi (ed.). Surcos de trascendencia en la modernidad secular. Madrid: La Catarata, 2021
Authors: Tirapu Intxaurrondo Xabier
Published: June 2022

No procede
FORMATION OF COMPUTATIONAL SCHEMES OF ADDITIONAL TARGETED CONSTRAINTS THAT REGULATE THE FREQUENCY SPECTRUM OF NATURAL OSCILLATIONS OF ELASTIC SYSTEMS WITH A FINITE NUMBER OF DEGREES OF MASS FREEDOM, THE DIRECTIONS OF MOVEMENT OF WHICH ARE PARALLEL, BUT D
Authors: Lyakhovich Leonid , Akimov Pavel
Published: June 2022

For some elastic systems with a finite number of degrees of freedom of masses, in which the directions of mass movement are parallel and lie in the same plane (for example, rods), special methods have been developed for creating additional constraints, the introduction of each of which purposefully increases the value of only one natural frequency and does not change any from the natural modes. The method of forming a matrix of additional stiffness coefficients that characterize such targeted constraint in this problem can also be applied when solving a similar problem for elastic systems with a finite number of degrees of mass freedom, in which the directions of mass movement are parallel, but do not lie in the same plane (for example, plates). At the same time, for such systems, only the requirements for the design schemes of additional targeted constraints are formulated, and not the methods for their creation. The distinctive paper proposes an approach that allows researcher to create computational schemes for additional targeted constraints for such systems. A variant of the computational scheme, represented by a rod system with one degree of activity, is considered. Some special properties of such targeted constraints are revealed. When forming the computational scheme, the material consumption for creating a constraint is minimized, and design restrictions are taken into account. Particular attention is paid to the modification of the computational scheme of the constraint, when, during its formation, rods appear that “pass” through the original system.
THE TRANSMISSION AND CIRCULATION OF WESTERN OPERA IN THE NETHERLANDS EAST INDIES, 1835-1869: PRELIMINARY OBSERVATIONS
Authors: Sugiyama Akiko
Published: June 2022

In October-November 1835 eight French professional performers directed by Ferdinand Minard completed six vaudeville shows in Batavia. The shows were highly acclaimed as they enlivened Batavia’s cultural life dominated by productions and performances by amateur artists. Inspired by the novel experience, local dilettantes were now calling for more professional shows, especially opera. Much to their delight, Minard and his ten some performers returned to Batavia in October 1836, specifically for operas. The second residency of Minard and his troupe marked the first known season of Théâtre-Français (French Theatre) that would continue into the 1860s and beyond under the successor series Théâtre Français de Batavia (French Theatre of Batavia). The arrival of Minard and his performers was a catalyst for a few important shifts in Batavia’s cultural life among European residents. It set in motion a tradition of annual professional and commercial productions by visiting performing artists. Minard’s engagement in 1836 included select performances of Italian opera, which placed Batavia within the emerging world culture of Italian opera. The journeys of Minard and his performers also saw early uses of steamboat and hotels that were antecedent to the age of steam to usher in globally with the opening of the Suez Canal in 1869. By focusing on Batavia, this article makes a fresh contribution to the global study on the transmission and circulation of Western opera in Southeast Asia.
FUNCTIONAL CAPACITY and quality of life IN CHILDREN AND ADOLESCENTS WITH SICkLE CELL ANEMIA
Authors: Silva Jonathan Luiz da , Soares Bruno Alvarenga , Silva Jaksoel , Blum Patrícia Belintani , Reimberg Mariana Mazzuca , Corso Simone Dal , Lanza Fernanda
Published: June 2022

Objective: To evaluate the functional capacity, pulmonary
function and quality of life of children and adolescents with sickle
cell anemia (SCA) and to test the reproducibility of functional capacity
tests in this population. Method: Cross-sectional study with
 volunteers with SCA genotype Hb-SS (SCAG), aged 6 to 18 years matched
in age and  gender to the control group (CG). Spirometry, 5-repetition
sit-to-stand test (5STS-test),  modified shuttle walk test (MSWT), and
Pediatric Quality of Life Questionnaire (PedsQL) were performed. The
reproducibility of 5STS-test and MSWT was evaluated:   Results:
48 volunteers of SCAG and 48 of CG were evaluated. Pulmonary function of
SCAG (FVC: 92 ± 15% pred.; FEV 1 /FVC: 84 ± 8% pred.) was worse than
the CG (104 ± 15% pred.; FEV 1 /FVC: 90 ± 6% pred.) p <
0.05. SCAG had worse functional capacity registered by distance walked:
576m (515-672m) and 5STS-test: 8 seconds (7.4-8.9seconds) compared to
the CG who showed distance walked: 1010m (887- 1219m) and 5STS-test: 7
seconds (7.0-8.1seconds), p < 0.001. SCAG had worse quality
compared to CG, p < 0.05. The reproducibility was good of MSWT
(ICC 0.99 (0.98-0.99 IC-95%)) and 5STS-test (ICC 0.80 (0.69 – 0.88), p
< 0.001 . Conclusion: Children and adolescents with
sickle cell anemia showed worse capacity to walk or run, and to perform
sit-to-stand test. Additionally, they have poor quality of life when
compared with their control peers. The MSWT and 5STS-test showed
reproducible to be applied in pediatric individual with SCA.
Análisis intrarregional de la estructura económica en la región Centro-norte de México
Authors: Castillo Dieguez Roberto Yoan , Climent Hernández José Antonio , Rincón García Ma. Benilde , Peña Estrada Claudia Cinthya
Published: June 2022

Problemática: la necesidad de un análisis intrarregional de la región Centro-norte de México, al ser la región de mayor crecimiento económico en el país, que permita dar respuesta al interrogante de investigación: ¿cómo se distribuyen las actividades económicas los estados de la región Centro-norte de México? Objetivos: realizar un análisis intrarregional para conocer cómo los estados de la región Centro-norte de México distribuyen sus actividades económicas y la manera en la que emplean sus recursos. Materiales y métodos: para el desarrollo de la investigación se utilizaron las técnicas de análisis intrarregional. La primera fue el coeficiente de localización para evaluar el nivel de concentración de los sectores de la economía de la región, la segunda técnica es el coeficiente de asociación territorial que ayuda a realizar comparaciones desde la perspectiva de la distribución geográfica. Resultados: se muestran los principales resultados en la región en cuanto a la concentración dentro de la economía en el período 2015-2019, además de las disparidades existentes en lo referente a la asociación territorial en ese período. Discusión: en la investigación se resalta la necesidad del análisis de las disparidades a nivel territorial y la necesidad del uso de herramienta de análisis de los gobiernos locales, así como la importancia de aplicar las técnicas de análisis regional en la evaluación de los territorios. Conclusiones: las técnicas de análisis intrarregional representan un instrumento esencial en el diagnóstico y evaluación de los estados de la república mexicana y pueden ser aplicadas a diversos indicadores que permitan mejorar el análisis de la situación de cada territorio. Contribución / originalidad: la contribución de la investigación radica en obtener la descripción que tiene el comportamiento del valor agregado bruto de los sectores primario, secundario y terciario de la región Centro-norte de México. Además, a partir del cálculo de coeficientes se puede analizar la concentración de las actividades económicas en la región.
Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin
Authors: Ito Yoshihiro , Sun Runan , Yagimuma Hiroshi , Taki Keigo , Mizoguchi Akira , Kobayashi Tomoko , Sugiyama Mariko , Onoue Takeshi , Tsunekawa Taku , Takagi Hiroshi , Hagiwara Daisuke , Iwama Shintaro , Suga Hidetaka , Konishi Hiroyuki , Kiyama Hiroshi , Arima Hiroshi , Banno Ryoichi
Published: June 2022

Leptin, a hormone secreted by adipocytes, exhibits therapeutic potential for the treatment of type 1 diabetes (T1D). Protein tyrosine phosphatase 1B (PTP1B) is a key enzyme that negatively regulates leptin receptor signaling. Here, the role of PTP1B in the treatment of T1D was investigated using PTP1B-deficient (knockout [KO]) mice and a PTP1B inhibitor. T1D wild-type (WT) mice induced by streptozotocin showed marked hyperglycemia compared with non-T1D WT mice. KO mice displayed significantly improved glucose metabolism equivalent to non-T1D WT mice, whereas peripheral or central administration of leptin partially improved glucose metabolism in T1D WT mice. Peripheral combination therapy of leptin and a PTP1B inhibitor in T1D WT mice improved glucose metabolism to the same level as non-T1D WT mice. Leptin was shown to act on the arcuate nucleus in the hypothalamus to suppress gluconeogenesis in liver and enhance glucose uptake in both brown adipose tissue and soleus muscle through the sympathetic nervous system. These effects were enhanced by PTP1B deficiency. Thus, treatment of T1D with leptin, PTP1B deficiency, or a PTP1B inhibitor was shown to enhance leptin activity in the hypothalamus to improve glucose metabolism. These findings suggest a potential alternative therapy for T1D.
Album Kolei Lwowsko-Czerniowieckiej i jego autor — Adolf Schoon von Corbitzthal (1830–1904)
Authors: Bednarek Anna
Published: June 2022

Kolej Lwowsko-Czerniowiecka otwarta została w 1866 r., a najważniejsze elementy jej infrastruktury, takie jak dworce i mosty, oraz tabor zostały udokumentowane w albumie fotograficznym, który powstał najprawdopodobniej na zamówienie dyrekcji Kolei na krótko po otwarciu linii, zapewne w 1867 r. Egzemplarze albumu w różnym stopniu kompletności zachowały się w kilku kolekcjach europejskich i amerykańskich. Autorem zdjęć jest Adolf Schoon von Corbitzthal (1830–1904), żołnierz armii austriackieji urzędnik kolejowy, zatrudniony na Kolei Lwowsko-Czerniowieckiej w latach 1866–1871. Album jest jednym z licznych zespołów zdjęć o tej tematyce, które powstały w drugiej połowie XIX w. głównie na zlecenie spółek budujących nowe linie i służyły przede wszystkim celom reprezentacyjnym.
Klimaklubbkvaler
Authors: Dokk Smith Ida , Lahn Bård , Øverland Indra
Published: June 2022

Norges internasjonale klimapolitikk har alltid hatt som målsetting å oppnå et mest mulig enhetlig globalt klimaregime. Parisavtalen reflekterer i stedet – og bidrar til å forsterke – et fragmentert klimaregime med et mylder av nye samarbeidsformer mellom land. I denne artikkelen trekker vi frem tre trender som preger det nye klimaregimet: et skifte fra klima- til grønn industripolitikk; økende spenning mellom klima- og handelspolitikk; og tettere sammenkobling mellom klima- og petroleumspolitikk. Vi viser hvordan nye klimaklubber både lager nye spilleregler og oppstår som motsvar til disse. Vi ønsker med dette å vise hvordan et fragmentert klimaregime fører til nye rammevilkår og utfordringer for norsk klimapolitikk. Klimaklubbkvalene omfatter både problemstillinger knyttet til hvem Norge skal samarbeide med og hvordan slikt samarbeid skal formaliseres, men også konsekvensene av å samarbeide med noen fremfor andre.
Abstract in English:Norway’s Climate Club QuandaryNorway’s international climate policy has always aimed at building a unitary global climate regime. However, the Paris Agreement reflects and accelerates the fragmentation of the climate regime and has been accompanied by the emergence of a myriad of new climate initiatives between countries. This article highlights three trends that characterize the emerging climate regime: a shift from climate to green industrial policy; rising tension between climate and trade policy and pressure to merge climate and petroleum policy. We illustrate how climate clubs both create new rules within the climate regime and are formed in response to such rules. Navigating this new international landscape will be a central challenge for Norwegian climate policy moving forward. Norway’s climate club quandary in this context implies choices between different political strategies and competing interests and with possible consequences for what type of climate regime Norway will contribute to. The climate club quandary is both related whom Norway seeks to collaborate with and the formalization of such collaboration, but also the consequences of collaborating with some countries and not with others.
PENANGGULANGAN ANARKISME SUPORTER MELALUI KEBIJAKAN HUKUM PIDANA (STUDI KASUS PERSIB BANDUNG DAN PERSIJA JAKARTA)
Authors: Astuti Laras , Purwanto Heri
Published: June 2022

ABSTRAK

Anarkisme suporter sebagai salah satu permasalahan klasik dalam penyelenggaraan liga sepakbola di Indonesia akan terus terjadi di setiap tahunnya, apabila tidak ada pola penyelesaian yang baik. Terakhir, anarkisme tersebut menewaskan suporter Persija Jakarta (Haringga Sirila) dalam pertandingan antara Persija Jakarta dan Persib Bandung di Stadion Gelora Bandung Lautan Api. Penanggulangan anarkisme suporter perlu dilakukan dengan serius agar tidak ada lagi suporter yang menjadi korban. Salah satu upaya yang dapat dilakukan dengan menggunakan kebijakan hukum pidana dalam menanggulangi anarkisme supporter. Tulisan ini merupakan hasil penelitian normatif dengan didasarkan pada inventarisasi dan identifikasi data sekunder secara deskriptif kualitatif melalui pendekatan analisis kasus. Berdasarkan hasil penelitian, penanggulangan anarkisme suporter dapat dilihat dari dua pendekatan. Pertama, upaya penal mengedepankan penghukuman kepada terdakwa pengeroyokan Haringga Sirila, tiga belas orang divonis penjara sedangkan satu orang di vonis bebas. Kedua, upaya non penal mengedepankan proses pencegahan dengan mengidentifikasi faktor penyebab terjadinya anarkisme suporter yang dapat dilakukan dengan kebijakan penanaman nilai-nilai sportivitas dan fairplay serta pembinaan suporter.

Kata kunci: anarkisme; hukum pidana; kebijakan; suporter.

 

ABSTRACT

Anarchism of supporters as one of the classic problems in organizing the football league in Indonesia which always occurs every year if it is not resolved properly. Latest, anarchism caused the death of Persija Jakarta supporters (Haringga Sirila) in a match between Persija Jakarta and Persib Bandung at the Gelora Bandung Lautan Api Stadium. Resolving anarchism of supporters needs to be taken seriously, so that no more supporters become victims. Criminal law policy can be used as an alternative in resolving anarchism of supporters. This paper is the result of normative research based on an inventory and identification of secondary data in a descriptive qualitative manner through a case analysis approach. Based on the research results, the resolving anarchism of supporters can be seen from two approaches. First, the penal approaches made the conviction of the defendant beatings Haringga Sirila, thirteen people were sentenced to prison while one person was sentenced to be acquitted. Non-penal approaches to prioritize the prevention process by identifying the factors causing the occurrence anarchism of supporters which can be carried out with a policy of forming the values of sportsmanship, fair play, and as well as fostering supporters.

Keywords: anarchism; criminal law; policy; supporters.
PENGAKUAN PUTUSAN PENYEDIA LAYANAN PENYELESAIAN SENGKETA NAMA DOMAIN ASING
Authors: Hassanah Hetty , Wahyudi Wahyudi
Published: June 2022

ABSTRAK

Pendaftaran dan putusan merupakan dasar hukum terbitnaya nama domain. Dalam Undang-Undang ITE hanya mengakui eksistensi Nama Domain (ND) hasil pendaftaran pada Registrar Asing (Ps. 24 ayat 3).  Teknologi informasi membuka ruang baru yang dinamakan cyberspace. Nama domain termasuk dalam cyberspace yang kepentingannya melibatkan seluruh pengguna internet akan tetapi tidak semua negara mempunyai regulasi yang sesuai dengan perkembangan teori dunia maya. Metode yuridis normatif yang digunakan dalam penelitian ini dengan spesifikasi yang bersifat deskriptif analitis. Teori “Code” atau “Architecture” Lawrence Lessig dapat diterapkan terkait pengakuan dan pelaksanaan putusan penyedia layanan penyelesaian sengketa nama domain yang melibatkan pihak Warga Negara Indonesia. Konsep pengaturan hukum terkait pengakuan dan pelaksanaan putusan penyedia layanan penyelesaian sengketa nama domain asing di Indonesia, adalah yang mampu mengikuti perkembangan best practices pada masyarakat TIK terkait kepemilikan nama domain berikut sistem penyelesaian sengketa secara online yang diatur oleh ICANN dalam UDRP dan dalam Perjanjian Registri dan Perjanjian Registrar  sesuai dengan teori “Code” atau “Architecture” dari Lawrence lessig.

Kata kunci: putusan arbitrase asing; nama domain; sengketa kepemilikan

 

ABSTRACT

Registration and sentence are the legal basis for issuing domain names. In the ITE Law, it only recognizes the existence of domain names  as a result of registration at the Foreign Registrar (Art. 24 paragraph 3). Domain names are included in cyberspace whose interests involve all internet users but not all countries have regulations that are in accordance with the development of cyber theory. juridical normative used in this research with descriptive analytical specifications. Lawrence Lessig's "Code" or "Architecture" theory can be applied regarding the recognition and implementation of decisions of domain name dispute resolution service providers involving Indonesian citizens. The concept of legal arrangements related to recognition andimplementation of decisions of foreign domain name dispute resolution service providers in Indonesia, are those that are able to follow the development of best practices in the ICT community related to domain name ownership and the online dispute resolution system regulated by ICANN in the UDRP and in the Registry Agreement and Registrar Agreement in accordance with the theory of "Code Or “Architecture” by Lawrence lessig.

 Keywords: foreign arbitration judgement; domain name; ownership disputes