bluuebunny/crossref_metadata_2025 huggingface dataset:
Ovarian reserve does not influence natural conception: insights from infertile women
Authors: Galati Giulia , Reschini Marco , Chine’ Alessandra , Benaglia Laura , Vigano’ Paola , Somigliana Edgardo , Vercellini Paolo , Muzii Ludovico
Published: September 2024

Purpose

There is several albeit not univocal evidence suggesting that ovarian reserve is not related to the chance of natural pregnancy, provided that the remnant follicular pool is sufficient to ensure regular menstrual cycles. Nevertheless, available studies have some methodological limitations, and the issue cannot be considered definitively ascertained.

Methods

To further address this issue, we retrospectively selected infertile women whose infertility diagnostic work-up was unremarkable (unexplained infertility-cases) and matched them by age and study period to a group of infertile women who were diagnosed with severe male infertility (controls). If ovarian reserve impacts on natural fertility, one had to expect lower ovarian reserve among women with unexplained infertility. Tested biomarkers included AMH, AFC and day 2–3 serum FSH. The primary aim was the frequency of women with serum AMH < 0.7 ng/ml.

Results

Two-hundred fifty-two women with unexplained infertility and 252 women with male infertility were included. All biomarkers of ovarian reserve did not differ between the study groups. AMH levels < 0.7 ng/mL were observed in 26 (10%) women with unexplained infertility and 35 (14%) women with male infertility (p = 0.28). The adjusted OR was 0.76 (95% CI: 0.44–1.33). Significant differences did not also emerge when repeating this dichotomous analysis using other biomarkers and other thresholds for the definition of low-ovarian reserve.

Conclusion

This study confirms that ovarian reserve is unremarkable to natural conception. Physicians and patients should be aware of this concept to avoid inappropriate counseling and undue clinical decisions.
Anatomy and connectivity of the Göttingen minipig subgenual cortex (Brodmann area 25 homologue)
Authors: Glud Andreas N. , Zaer Hamed , Orlowski Dariusz , Nielsen Mette Slot , Sørensen Jens Christian H. , Bjarkam Carsten R.
Published: September 2024

Background

The subgenual gyrus is a promising target for deep brain stimulation (DBS) against depression. However, to optimize this treatment modality, we need translational animal models.

Aim

To describe the anatomy and connectivity of the Göttingen minipig subgenual area (sgC).

Materials and methods

The frontal pole of 5 minipigs was cryosectioned into 40 μm coronal and horizontal sections and stained with Nissl and NeuN-immunohistochemistry to visualize cytoarchitecture and cortical lamination. Eight animals were unilaterally stereotaxically injected in the sgC with anterograde (BDA) and retrograde (FluoroGold) tracers to reveal the sgC connectivity.

Results

In homology with human nomenclature (Brodmann 1909), the minipig sgC can be subdivided into three distinct areas named area 25 (BA25), area 33 (BA33), and indusium griseum (IG). BA25 is a thin agranular cortex, approximately 1 mm thick. Characteristically, perpendicular to the pial surface, cell-poor cortical columns separate the otherwise cell-rich cortex of layer II, III and V. In layer V the cells are of similar size as seen in layer III, while layer VI contains more widely dispersed neurons. BA33 is less differentiated than BA25. Accordingly, the cortex is thinner and displays a complete lack of laminar differentiation due to diffusely arranged small, lightly stained neurons. It abuts the IG, which is a neuron-dense band of heavily stained small neurons separating BA33 directly from the corpus callosum and the posteriorly located septal nuclear area.

Due to the limited area size and nearby location to the lateral ventricle and longitudinal cerebral fissure, only 3/8 animals received sgC injections with an antero- and retrograde tracer mixture. Retrograde tracing was seen primarily to the neighbouring ipsilateral ventral- and mPFC areas with some contralateral labelling as well. Prominent projections were furthermore observed from the ipsilateral insula, the medial aspect of the amygdala and the hippocampal formation, diencephalon and the brainstem ventral tegmental area. Anterograde tracing revealed prominent projections to the neighbouring medial prefrontal, mPFC and cingulate cortex, while moderate staining was noted in the hippocampus and adjoining piriform cortex.

Conclusion

The minipig sgC displays a cytoarchitectonic pattern and connectivity like the human and may be well suited for further translational studies on BA25-DBS against depression.
Melanoma genomics – will we go beyond BRAF in clinics?
Authors: Mirek Justyna , Bal Wiesław , Olbryt Magdalena
Published: September 2024

In the era of next-generation sequencing, the genetic background of cancer, including melanoma, appears to be thoroughly established. However, evaluating the oncogene BRAF mutation in codon V600 is still the only companion diagnostic genomic test commonly implemented in clinics for molecularly targeted treatment of advanced melanoma. Are we wasting the collected genomic data? Will we implement our current genomic knowledge of melanoma in clinics soon? This question is rather urgent because new therapeutic targets and biomarkers are needed to implement more personalized, patient-tailored therapy in clinics. Here, we provide an update on the molecular background of melanoma, including a description of four already established molecular subtypes: BRAF+, NRAS+, NF1+, and triple WT, as well as relatively new NGS-derived melanoma genes such as PREX2, ERBB4, PPP6C, FBXW7, PIK3CA, and IDH1. We also present a comparison of genomic profiles obtained in recent years with a focus on the most common melanoma genes. Finally, we propose our melanoma gene panel consisting of 22 genes that, in our opinion, are “must-have” genes in both melanoma-specific genomic tests and pan-cancer tests established to improve the treatment of melanoma further.
Transient MRI changes and neurological deterioration in glioblastoma upon SARS-CoV-2 infection
Authors: Zeyen Thomas , Friker Lea L. , Paech Daniel , Schaefer Niklas , Weller Johannes , Zschernack Valentina , Layer Julian P. , Schneider Matthias , Potthoff Anna-Laura , Bernhardt Marit , Sanders Christine , Kristiansen Glen , Hoelzel Michael , Gkika Eleni , Radbruch Alexander , Pietsch Torsten , Herrlinger Ulrich , Schaub Christina
Published: September 2024

Purpose

Little is known about the effect of SARS-CoV-2 infection on glioblastoma (GBM) growth, metabolism, and prognosis. Immunological changes within GBM tissue are potentially symptomatic, underlining the urgent need for a better understanding of this phenomenon. To date, the complex underlying biology has not been fully elucidated. A decisive role of the tumor microenvironment (TME) and the components of the immune system acting within it is assumed.

Methods

Immunohistochemical staining of SARS-CoV-2 spike protein and immune cell infiltration of TME was performed on the tumor tissue of one patient. This patient developed hemiparesis 14 days after symptomatic SARS-CoV-2 infection, leading to tumor diagnosis. Subsequently and after biopsy, there was an unexpectedly good response to chemotherapy only. In looking for further evidence of the potential of SARS-CoV-2 to influence the course of GBM, two additional adult patients that had transient MRI changes and neurological deterioration following SARS-CoV-2 infection were evaluated.

Results

In the patient for whom neurological deterioration in the course of SARS-CoV-2 led to GBM diagnosis, immunohistochemistry revealed virus-specific protein accumulation in the tumor cells, microglial activation, and the formation of T-cell nodules. In the other two patients, the findings were compatible with symptomatic pseudoprogression that occurred in a temporal relationship with SARS-CoV-2 infection.

Conclusion

The results indicate a possible association between clinically relevant changes in GBM biology and SARS-CoV-2 infection, with histological confirmation of SARS-CoV-2-associated changes within the tumor tissue. The exact pathomechanism and underlying inflammatory pathways require further investigation.
Herbivore kairomones affect germination speed, seedling growth, and herbivory
Authors: Pellegrini Brooke A. , Pintado Lina S. , Souza Paige N. , Bhavanam Santhi P. , Orians Colin M. , Orrock John L. , Preisser Evan L.
Published: September 2024

Seeds and seedlings are particularly vulnerable to herbivory. Unlike mature plants, which can wait until herbivory is experienced to induce defense, seeds and seedlings face mortality if they wait. Slug mucus functions as a kairomone, a non-attack-related substance emitted by consumers that is detected by a prey species (in this case, plants). While snail mucus has been shown to induce defense in seedlings, it is not widely confirmed whether slugs have the same effect and whether seeds can also detect and react to such herbivore cues. We investigated how exposure to Arion subfuscus mucus affected growth and defense in Brassica nigra seeds and seedlings. Seeds exposed to slug mucus germinated 5% faster than control (water only) seeds, but the resulting seedlings weighed 16% less than control seedlings. To test whether this difference results from herbivore-exposed plants allocating energy from growth to defense, we conducted choice bioassays assessing slug preference for control seedlings versus seedlings that were either (A) exposed to mucus only as a seed; or (B) exposed to mucus as a seed and seedling. While slugs did not differentiate between control seedlings and ones exposed to herbivore cues only as a seed, they ate 88% less biomass of seedlings exposed to mucus as both seeds and seedlings. These results suggest that slug mucus induces changes in plant traits related to defense and growth/competitive ability. Future research should determine the chemical mechanisms of this induced defense.
Block Volume and Shape: Comparison of Calculation Methods and Investigation of Possible Relationships
Authors: Taboni Battista , Ferrero Anna Maria , Umili Gessica
Published: September 2024

In dealing with rockfall risk mitigation, a proper assessment of the phenomenon is the key to correctly and precisely managing its possible consequences. In doing so, numerical simulations are an unavoidable step of the assessment process. The proper description of the slope and the falling rock is paramount. Thus, it is highly relevant to accurately assess block size and shape. Block size directly defines the kinetic energy involved in the phenomenon, whilst shape directly influences its trajectory. Tools to properly assess both block size and shape are available, either in analytical form or relying upon Discrete Fracture Network (DFN) models. However, at present, no concrete demonstration of the equivalence of these two methods is provided in the literature. Moreover, block size and shape are always treated separately, while it is likely that a relationship of some sort exists between the two as they derive from the same features of the rock mass (i.e., the 3D geometry of its discontinuities). This paper presents a comprehensive study concerning (1) the comparison between DFN and analytical approaches and (2) the existence and quantification of a shape–size correlation. A modeling campaign consisting of 20 different geometrical structures is performed with both methods, with the aim of obtaining In Situ Block Size Distributions and Shape Distributions. Although the DFN and the analytical approach have different advantages and disadvantages, they have proved to be comparable in terms of results. Both methods identify the existence of a correlation between shape and size of the blocks: the shape distribution changes with reference to block size. This result points out the importance of implementing shape distribution in rockfall numerical simulations. Finally, a suitable case study from the literature has been selected to test the applicability and usefulness of the new findings for the design of rockfall barriers.
‘Watkins’ & ‘Watkins2.0’: Smart phone applications (Apps) for gait-assessment in normal pressure hydrocephalus and decompensated long-standing overt ventriculomegaly
Authors: Tariq Kanza , Thorne Lewis , Toma Ahmed , Watkins Laurence
Published: September 2024

Objective

Gait disturbance is one of the features of normal pressure hydrocephalus (NPH) and decompensated long-standing overt ventriculomegaly (LOVA). The timed-up-and-go (TUG) test and the timed-10-m-walking test (10MWT) are frequently used assessments tools for gait and balance disturbances in NPH and LOVA, as well as several other disorders. We aimed to make smart-phone apps which perform both the 10MWT and the TUG-test and record the results for individual patients, thus making it possible for patients to have an objective assessment of their progress. Patients with a suitable smart phone can perform repeat assessments in their home environment, providing a measure of progress for them and for their clinical team.

Methods

10MWT and TUG-test were performed by 50 healthy adults, 67 NPH and 10 LOVA patients, as well as 5 elderly patients as part of falls risk assessment using the Watkins2.0 app. The 10MWT was assessed with timed slow-pace and fast-pace. Statistical analysis used SPSS (version 25.0, IBM) by paired t-test, comparing the healthy and the NPH cohorts. Level of precision of the app as compared to a clinical observer using a stopwatch was evaluated using receiver operating characteristics curve.

Results

As compared to a clinical observer using a stopwatch, in 10MWT the app showed 100% accuracy in the measure of time taken to cover distance in whole seconds, 95% accuracy in the number of steps taken with an error ± 1–3 steps, and 97% accuracy in the measure of total distance covered with error of ± 0.25–0.50 m. The TUG test has 100% accuracy in time taken to complete the test in whole seconds, 97% accuracy in the number of steps with an error of ± 1–2 steps and 87.5% accuracy in the distance covered with error of ± 0.50 m. In the measure of time, the app was found to have equal sensitivity as an observer. In measure of number of steps and distance, the app demonstrated high sensitivity and precision (AUC > 0.9). The app also showed significant level of discrimination between healthy and gait-impaired individuals.

Conclusion

‘Watkins’ and ‘Watkins2.0’ are efficient apps for objective performance of 10MWT and the TUG-test in NPH and LOVA patients and has application in several other pathologies characterised by gait and balance disturbance.
Don’t jump the gun quite yet: aiming for the true target in plant neurobiology research
Authors: Calvo Paco , Raja Vicente , Segundo-Ortin Miguel
Published: September 2024

In their recent paper, Kingsland and Taiz argue that proponents of plant intelligence and plant neurobiology misuse historical sources to support their claims, suggesting a pattern of bias. They critique the reliance on subjective judgments and the systematic misuse of past literature by notable scientists. This response addresses their criticisms while adhering to Rapoport’s rules to foster constructive academic dialogue. We emphasize the importance of evidence-based research and highlight areas of agreement, including the fallacy of appealing to authority and the necessity for more robust empirical evidence. However, we also challenge their selective citation practices and argue that their narrative itself is subject to the same criticisms they levy. By examining recent works and pointing out overlooked rebuttals, we aim to clarify misconceptions and advocate for a more nuanced understanding of plant intelligence research. This dialogue underscores the need for rigorous, respectful scientific discourse to advance the field.
Direct versus fully digital indirect bracket bonding: a split-mouth randomized clinical trial on accuracy
Authors: Hoekstra-van Hout Pauline M.J. , Hoekstra Jan Willem M. , Bruggink Robin , Bronkhorst Ewald M. , Ongkosuwito Edwin M.
Published: September 2024

Objectives

The primary aim is to assess differences in accuracy of orthodontic bracket positioning between fully digital indirect bracket bonding (IDB) and conventional direct bracket bonding (DBB). The secondary aims are to assess differences in bracket bonding failures, bracket repositioning need, clinician experience and patient satisfaction.

Materials and methods

This prospective study was designed as a split-mouth randomized clinical trial. In total, 35 patients were analyzed with a six month follow-up period. Translational and orientational deviations from the planned bracket position were determined. Clinician experience and patient satisfaction were evaluated by means of a survey.

Results

The difference in translation was 0.34 mm (95% CI: 0.238–0.352, p = 0.017), the difference in orientation was 4.80˚ (95% CI: 3.858–5.727, p < 0.001), both in favour of IDB. IDB showed significantly more immediate (IDB: 3.9%, DBB: 0%) and late (IDB: 5.4%, DBB: 2.5%, p = 0.008) bonding failures. Clinicians and patients experienced a shorter clinical chair time with indirect bonding over direct bonding.

Conclusions

IDB bracket positioning leads to significant smaller translation and orientation deviations from digital IDB planning, than DBB bracket positioning. However, IDB leads to more immediate bonding failures than DBB. The majority of patients preferred IDB over DBB, due to a shorter clinical chair time.

Clinical relevance

This study adds to the knowledge of IDB in orthodontics and contributes to evidence on this technique. This evidence is applicable in everyday orthodontics, with respect to patient satisfaction and technical limits of IDB. The trial was registered in the Dutch Trial Register and the International Clinical Trials Registry Platform (ICTRP) of the World Health Organization (WHO), number NL9411.
Evaluating treatment practices and challenges in systemic Juvenile Idiopathic Arthritis: a comprehensive survey analysis
Authors: Tan Xiaohua , Zhao Xiaozhen , Deng Jianghong , Li Chao , Zhang Junmei , Li Shipeng , Li Caifeng
Published: September 2024

Objective

This study aims to assess current diagnostic and management for systemic Juvenile Idiopathic Arthritis (sJIA) among physicians, evaluate the challenges encountered in diagnosis and treatment, and identify the educational needs and professional development engagements of physicians managing sJIA.

Methods

A nationwide survey was conducted from November 2023 to March 2024 across tertiary and secondary pediatric and general hospitals in China. The survey targeted physicians with at least three years of specialty experience, resulting in 310 valid responses from 25 provinces, autonomous regions, and municipalities. The survey collected data on diagnostic practices, treatment approaches, and professional development related to sJIA. Data collection was facilitated through WeChat, and statistical analysis was performed using descriptive statistics. Ethical approval was obtained from the Ethics Committee of Beijing Children’s Hospital, with informed consent provided electronically by participants.

Results

The survey indicated that all physicians encountered suspected or confirmed cases of sJIA, highlighting its prevalence and the diagnostic challenges associated. Regarding diagnostic standards, 53.9% of physicians used the “Consensus on the Diagnosis and Treatment of sJIA and Macrophage Activation Syndrome,” 18.1% followed the International League of Associations for Rheumatology (ILAR) standards, and 24.8% adhered to the Pediatric Rheumatology International Trials Organization (PRINTO) standards. In treatment strategies, glucocorticoids and IL-6 receptor monoclonal antibodies were extensively used, with the latter receiving “excellent” and “satisfactory” ratings of 46.5% and 36.1%, respectively, demonstrating high efficacy and acceptance. Main challenges included high treatment costs, complexity of diagnosis, patient compliance issues, and potential long-term side effects of biologics. Additionally, 126 doctors (40.7%) actively participated in more than three academic conferences or systematic learning courses related to sJIA, indicating a strong demand for ongoing education, particularly in new treatment developments and diagnostic skills.

Conclusion

The findings emphasize the necessity for standardized diagnosis and customized treatment plans tailored to patient-specific conditions in managing sJIA.

Key Points• The survey highlights the prevalence and clinical challenges of sJIA among physicians, emphasizing the importance of vigilant diagnosis, multi-system involvement, and differential diagnosis to improve treatment outcomes and patient quality of life.
Research progress on the pathogenesis of AKI complicated by ECMO
Authors: Sun Keke , Yao Congcong , Xu Guowu , Wang Jinxiang , Shou Songtao , Jin Heng
Published: September 2024

Background

Extracorporeal membrane oxygenation (ECMO) stands as a pivotal intervention for patients grappling with cardiopulmonary insufficiency. However, alongside its therapeutic benefits, ECMO carries the risk of complications, with acute kidney injury (AKI) emerging as a significant concern. The precise pathophysiological underpinnings of AKI in the context of ECMO remain incompletely elucidated.

Methods

A comprehensive literature review was conducted to explore the epidemiology and pathophysiological mechanisms underlying the utilization of ECMO in the management of AKI.

Results

ECMO initiates a multifaceted cascade of inflammatory reactions, encompassing complement activation, endothelial dysfunction, white blood cell activation, and cytokine release. Furthermore, factors such as renal hypoperfusion, ischemia–reperfusion injury, hemolysis, and fluid overload exacerbate AKI. Specifically, veno-arterial ECMO (VA-ECMO) may directly induce renal hypoperfusion, whereas veno-venous ECMO (VV-ECMO) predominantly impacts pulmonary function, indirectly influencing renal function.

Conclusion

While ECMO offers significant therapeutic advantages, AKI persists as a potentially fatal complication. A thorough comprehension of the pathogenesis underlying ECMO-associated AKI is imperative for effective prevention and management strategies. Moreover, additional research is warranted to delineate the incidence of AKI secondary to ECMO and to refine clinical approaches accordingly.
Intestinal permeability disturbances: causes, diseases and therapy
Authors: Macura Barbara , Kiecka Aneta , Szczepanik Marian
Published: September 2024

Nowadays, a pathological increase in the permeability of the intestinal barrier (the so-called leaky gut) is increasingly being diagnosed. This condition can be caused by various factors, mainly from the external environment. Damage to the intestinal barrier entails a number of adverse phenomena: dysbiosis, translocation of microorganisms deep into the intestinal tissue, immune response, development of chronic inflammation. These phenomena can ultimately lead to a vicious cycle that promotes the development of inflammation and further damage to the barrier. Activated immune cells in mucosal tissues with broken barriers can migrate to other organs and negatively affect their functioning. Damaged intestinal barrier can facilitate the development of local diseases such as irritable bowel disease, inflammatory bowel disease or celiac disease, but also the development of systemic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, hepatitis, and lupus erythematosus, neurodegenerative or psychiatric conditions, or metabolic diseases such as diabetes or obesity. However, it must be emphasized that the causal links between a leaky gut barrier and the onset of certain diseases often remain unclear and require in-depth research. In light of recent research, it becomes crucial to prevent damage to the intestinal barrier, as well as to develop therapies for the barrier when it is damaged. This paper presents the current state of knowledge on the causes, health consequences and attempts to treat excessive permeability of the intestinal barrier.
Bridging MDE and AI: a systematic review of domain-specific languages and model-driven practices in AI software systems engineering
Authors: Rädler Simon , Berardinelli Luca , Winter Karolin , Rahimi Abbas , Rinderle-Ma Stefanie
Published: September 2024

Technical systems are becoming increasingly complex due to the increasing number of components, functions, and involvement of different disciplines. In this regard, model-driven engineering techniques and practices tame complexity during the development process by using models as primary artifacts. Modeling can be carried out through domain-specific languages whose implementation is supported by model-driven techniques. Today, the amount of data generated during product development is rapidly growing, leading to an increased need to leverage artificial intelligence algorithms. However, using these algorithms in practice can be difficult and time-consuming. Therefore, leveraging domain-specific languages and model-driven techniques for formulating AI algorithms or parts of them can reduce these complexities and be advantageous. This study aims to investigate the existing model-driven approaches relying on domain-specific languages in support of the engineering of AI software systems to sharpen future research further and define the current state of the art. We conducted a Systemic Literature Review (SLR), collecting papers from five major databases resulting in 1335 candidate studies, eventually retaining 18 primary studies. Each primary study will be evaluated and discussed with respect to the adoption of (1) MDE principles and practices and (2) the phases of AI development support aligned with the stages of the CRISP-DM methodology. The study’s findings show that language workbenches are of paramount importance in dealing with all aspects of modeling language development (metamodel, concrete syntax, and model transformation) and are leveraged to define domain-specific languages (DSL) explicitly addressing AI concerns. The most prominent AI-related concerns are training and modeling of the AI algorithm, while minor emphasis is given to the time-consuming preparation of the data sets. Early project phases that support interdisciplinary communication of requirements, such as the CRISP-DM Business Understanding phase, are rarely reflected. The study found that the use of MDE for AI is still in its early stages, and there is no single tool or method that is widely used. Additionally, current approaches tend to focus on specific stages of development rather than providing support for the entire development process. As a result, the study suggests several research directions to further improve the use of MDE for AI and to guide future research in this area.
Outcomes of five cases of retinoblastoma with optic nerve invasion on imaging
Authors: Onishi Tamae , Nishina Sachiko , Yokoi Tadashi , Yoshida Tomoyo , Hayashi Shion , Morikawa-Anzai Hazuki , Azuma Noriyuki , Kiyotani Chikako , Terashima Keita , Yoshioka Takako , Ogiwara Hideki , Fuji Hiroshi , Kitamura Masayuki , Tsutsumi Yoshiyuki
Published: September 2024

Purpose

To investigate the timing of enucleation, treatment course, and outcome for retinoblastoma (RB) with optic nerve (ON) invasion on imaging.

Study design

Retrospective clinical study.

Methods

Of the 160 patients with RB who presented to the National Center for Child Health and Development in Japan between 2005 and 2022, ON invasion on imaging at the initial presentation was seen in five patients. The clinical, computed tomography (CT), and magnetic resonance imaging (MRI) findings, and treatment courses were reviewed retrospectively.

Results

MRI showed ON invasion in all five patients (three with unilateral RB, 2 with bilateral RB); in two patients CT detected no invasion. Enucleation was performed in four patients, three of whom underwent neoadjuvant therapy and one had a positive ON resection margin following the enucleation as initial treatment. One patient did not undergo enucleation due to cerebrospinal fluid dissemination. All enucleated patients underwent adjuvant chemotherapy. Four patients underwent radiotherapy. During follow-up (mean, 89.4 months), four patients survived and one died.

Conclusion

MRI is recommended to evaluate ON invasion and determine the timing of enucleation for RB. The appropriate choice of neoadjuvant or adjuvant therapy would be helpful to avoid radiotherapy for RB with ON invasion on imaging.
Management of preoperative hypertension and anxiety based on early monitoring of pulse rate before cataract surgery
Authors: Ono Takashi , Iwasaki Takuya , Tomari Rie , Sakisaka Toshihiro , Mori Yosai , Nejima Ryohei , Miyata Kazunori
Published: September 2024

Purpose

Few studies have addressed the clinical impact of fluctuation in pulse rate before cataract surgery. This study aimed to determine the effectiveness of prior pulse monitoring and intervention to prevent blood pressure changes in patients undergoing cataract surgery under local anesthesia.

Study design

Retrospective study

Methods

Patients who underwent cataract surgery under local anesthesia were included. In the pulse rate (PR) group, intervention was performed on the basis of early monitoring of blood pressure and PR changes. In the conventional group, blood pressure was managed on the basis of blood pressure alone. Systolic blood pressure, diastolic blood pressure, intraoperative nicardipine use, and physician consultation time were retrospectively compared between the groups.

Results

The study included 684 eyes from 684 patients aged 73.5 ± 9.5 years (PR group: 297 eyes, conventional group: 387 eyes). No intergroup differences were found in systolic blood pressure or pulse and heart rates; however, diastolic blood pressure was significantly lower in the PR group than in the conventional group at both the beginning and the end of surgery (P <.001 and P = .0028, respectively). Intravenous nicardipine administration in the operating room was significantly less frequent in the PR group (P = .041), and physician consultation time after entering the operating room and at the beginning of surgery was significantly shorter in the PR group (both P <.001).

Conclusion

Early monitoring of PR with blood pressure and intervention were effective for preventing preoperative hypertension.
Trophic niche of a nonnative invader and environmental drivers of its increasing populations in the coastal Everglades
Authors: Kahmann Grace , Rehage Jennifer S. , Massie Jordan A. , Nelson James A. , Santos Rolando O. , Viadero Natasha M. , Ryan James W. , Boucek Ross E. , Crane Derek P. , Rezek Ryan J.
Published: September 2024

The Florida Everglades is a critically important, but highly threatened ecosystem that is becoming increasingly susceptible to the invasion of non-native species. This study investigated the ecological role of the invasive peacock eel (Macrognathus siamensis) within this ecosystem using 15 years of electrofishing data and stable isotope analysis. We investigated the population trends of peacock eels at the marsh-mangrove ecotone of the Shark River Estuary, the environmental factors contributing to their abundance, and the potential interactions they may have with native fish assemblages and coastal food webs. We used stable isotope analysis to provide insights into the basal resource contribution to peacock eels and hypervolume analysis to determine peacock eel trophic niche size and overlap with native species. Results of this study found that peacock eel abundance has rapidly increased, and their populations are strongly related to hydroclimatic regimes. Peacock eel abundance was positively associated with warmer water temperatures and greater marsh inundation periods. The trophic niche of peacock eels was significantly smaller in volume than that of native sunfishes (Lepomis spp.) indicating lower intraspecific resource use variability and suggesting a limited potential for inter-specific competition with these taxa. However, in recent years, the catch of peacock eels has outnumbered the catch of all native sunfishes combined. The feeding habits and pervasiveness of peacock eels in the coastal Everglades could lead to a decrease in abundance of benthic prey items targeted by peacock eels and alter food web dynamics in the system. Based on these data, peacock eel populations are predicted to continue to increase, highlighting the importance of continued monitoring of their potential impact on native fish assemblages and food webs.
Developing a city-wide, community-engaged cancer disparities research agenda
Authors: Leader Amy E. , Song Yawei , González Evelyn T. , Fortune Thierry , Graciani Nilsa , Zeigler-Johnson Charnita , Glanz Karen
Published: September 2024

Introduction

In response to high levels of cancer disparities in Philadelphia, PA, three NCI-designated clinical cancer centers formed Philadelphia Communities Conquering Cancer (PC3) to bring stakeholders together and establish infrastructure for future cancer reducing initiatives. The PC3 coalition aimed to develop a prioritized cancer disparities research agenda in order to align cancer center resources and research interests with the concerns of the community about cancer, and to ensure that initiatives were patient- and community-centered.

Methods

Agenda development activities culminated in a city-wide cancer disparities conference. The conference, attended by 55 diverse stakeholders, was the venue for small group discussion sessions about cancer concerns related to prevention, early detection, treatment, survivorship, and quality of life. Sessions were guided by a moderator guide and were audiorecorded, transcribed, and analyzed by the PC3 leadership team. Results were reviewed and consensus was achieved with the help of PC3’s Stakeholder Advisory Committee.

Results

Stakeholders identified four thematic areas as top priorities for cancer disparities research and action in Philadelphia: communication between patients, providers, and caregivers; education that reaches patients and community members with tailored and targeted information; navigation that assists people in finding and accessing the right cancer screening or treatment option for them; and representation that diversifies the workforce in clinics, cancer centers, and research offices.

Conclusion

A community-informed, prioritized research agenda provides a road map for the three cancer centers to collaborate on future initiatives that are important to patients and stakeholders, to ultimately reduce the burden of cancer for all Philadelphians.
Children’s perspectives on self-regulated learning: A co-design study on children’s expectations towards educational technology
Authors: Amaefule Chimezie O. , Britzwein Jan , Yip Jason C. , Brod Garvin
Published: September 2024

Self-regulated learning (SRL) involves processes by which learners purposefully direct their cognitions, emotions, and behaviors towards the achievement of personal learning goals. Research has shown that young learners often struggle with SRL. Educational technology could be useful to support their SRL. However, it remains unclear how support mechanisms can be best adapted to the needs of children. Adopting a participatory design (PD) approach involving an intergenerational design team of six children (ages 10–12) and three adult facilitators, we explored children’s perspectives on factors that facilitate or hinder their SRL, and what kinds of support they desire. The study consisted of three in-person co-design sessions (one per week) lasting about 90 min each over three weeks. The sessions centered on brainstorming needs, evaluating existing technology, ideating and designing paper prototypes of study-planner apps. Our findings indicate that children primarily voice the need for support to better organize their study and to keep focused on the learning task at hand. They also make it clear that SRL support systems must be designed to be attractive and fun. Children’s subsequent evaluation of app features and the prototypes which they designed were consistent with these needs. Taken together, our study indicates that children can voice clear and consistent preferences for SRL support with educational technology. By including children in the design process, we can ensure that educational technologies effectively meet their needs, enhance their learning experiences, and promote self-regulation and academic success.
Moderating Factors in the Relationship Between Home Literacy Environment and Early Word Reading Skills: Results from Cantonese–English Bilinguals
Authors: Zhang Anna Jia-Jun , Wong Kelly Chik Wa , Lee Cherry Sze Wing , Inoue Tomohiro
Published: September 2024

We examined the associations between home literacy environment (HLE) and children’s word reading in L1 Cantonese and L2 English and whether the associations were moderated by other child- and family-related factors (children’s grade level, reading interest, and family socioeconomic status [SES]) in Hong Kong Chinese families. Participants were 190 children (Mage = 86.05 months; 54.7% female) in Grades 1 and 2, and they were tested on their word reading skills (accuracy and fluency) in L1 Cantonese and L2 English. One corresponding parent of each child responded to a questionnaire assessing two aspects of HLE (parent teaching and access to literacy resources), family SES, and their child’s reading interest. Results showed that access to literacy resources was associated with L2 English reading but not L1 Cantonese reading, regardless of grade level, parent-rated reading interest, or SES. In addition, whereas parent teaching was positively associated with L2 English reading in Grade 1, it was negatively associated with L2 English reading in Grade 2. These results suggest that whereas access to literacy resources may be positively associated with L2 English reading across different family contexts, the role of parent teaching in L2 English reading may change during this developmental period.
The endogeneity of optimum currency areas in light of pan-European intra-industry trade patterns and business cycle synchronicity
Authors: Steinert Frank Niklas , Althammer Wilhelm
Published: September 2024

The creation of a common European currency has been scrutinized in the context of optimum currency area theory since its origin in Mundell (1961). The debate gained particular prominence in light of the endogeneity hypothesis (Frankel and Rose 1998), which argues that once two countries establish a common currency, their economic structures and cycles increasingly align due to strengthening intra-industry trade. By contrast, the specialization hypothesis (Eichengreen 1992; Krugman and Venables 1996) argues that the creation of a currency union will predominantly increase inter-industry trade, ultimately lowering business cycle correlation. To test these views, we establish several indices of bilateral trade intensity across EU members using input–output data, measuring gross and so-called value-added trade, which also considers the contribution of intermediary goods in the production of final exports. The results of the fixed effect panel data framework indicate a strong and robust empirical relationship between growth correlations and intra-industry trade, much in line with both Mundell’s and Frankel and Rose’s theories. However, we cannot establish a similarly robust relationship between total trade intensity and growth correlations. We reconcile these results by identifying a statistically significant relationship between economic alignment and trade when only considering industrial production, highlighting the importance of pan-European industrial supply chains for European economic integration. Rerunning our regression framework on the subsample of the eurozone indicates that the common currency area displayed even stronger properties of an optimum currency area than the entire European Union.
A data-centric approach for ethical and trustworthy AI in journalism
Authors: Dierickx Laurence , Opdahl Andreas Lothe , Khan Sohail Ahmed , Lindén Carl-Gustav , Guerrero Rojas Diana Carolina
Published: September 2024

AI-driven journalism refers to various methods and tools for gathering, verifying, producing, and distributing news information. Their potential is to extend human capabilities and create new forms of augmented journalism. Although scholars agreed on the necessity to embed journalistic values in these systems to make AI systems accountable, less attention was paid to data quality, while the results’ accuracy and efficiency depend on high-quality data in any machine learning task. Assessing data quality in the context of AI-driven journalism requires a broader and interdisciplinary approach, relying on the challenges of data quality in machine learning and the ethical challenges of using machine learning in journalism. To better identify these, we propose a data quality assessment framework to support the collection and pre-processing stages in machine learning. It relies on three of the core principles of ethical journalism—accuracy, fairness, and transparency—and participates in the shift from model-centric to data-centric AI, by focusing on data quality to reduce reliance on large datasets with errors, making data labelling consistent, and better integrating journalistic knowledge.
Crucible-less Processing of Ti with TiC Heterogeneous Nucleation Site Particles by Electrostatic Levitation
Authors: Watanabe Yoshimi , Takahashi Goro , Saguchi Ryosei , Sato Hisashi , Aoki Hirokazu , Suzuki Shinsuke , Nakano Shizuka , Watanabe Yuki , Koyama Chihiro , Oda Hirohisa , Ishikawa Takehiko
Published: September 2024

In this study, the microstructure, hardness, density, viscosity, and surface tension of molten pure Ti with TiC particles were studied via electrostatic levitation experiments, where the electrostatic levitation experiment involved container-less processing, which can suppress heterogeneous nucleation via crucibles. Microstructural observation revealed long needle-shaped α-grains across the whole area in the pure Ti sample. On the other hand, smaller needle-shaped α-grains were found in the samples with TiC particles. However, the detailed microstructural analysis of Ti + 0.7vo l%TiC sample revealed that the fine α-grains observed in the Ti + 0.7vo l%TiC are transformed from single grain of prior β phase. This is because the TiC particles dissolve into the molten Ti during the electrostatic levitation experiment. Instead, Ti–rich TiC precipitates formed by cooling can act as pinning sites rather than heterogeneous nucleation sites, which results in a finer microstructure for the samples with TiC particles during the electrostatic levitation experiment. The density of the samples is linearly related to the temperature, and it decreases with increasing temperature. In addition, a higher density is observed for the samples with TiC particles. Although linear relationships between the surface tension and temperature were found, the addition of TiC particles had no notable effect on the viscosity of the molten pure Ti.
Family Financial Socialisation and its Impact on Financial Confidence, Intentions, and Behaviours among New Zealand Adolescents
Authors: Agnew Steve , Sotardi Valerie A.
Published: September 2024

This study investigated the impact of family financial socialisation on the financial perceptions and behaviours of adolescents. Drawing from social learning theory, Gudmunson and Danes’ model of family financial socialisation, and the theory of planned behaviour, we examined the influence of family affluence and family financial openness on adolescents’ financial confidence, intentions, and behaviours. The research also explores gender differences and the distinct effects of family socialisation in banking and budgeting contexts. With a large sample of adolescents in New Zealand (n = 5,370), results using structural equation modelling reveal that family affluence corresponds with a higher perception of family financial openness, which influences their confidence in specific financial domains such as banking and budgeting. Our results also highlight a gap between confidence, intentions, and action in financial behaviours, with gender differences also impacting this dynamic. The findings offer insights for parents, policymakers, and financial institutions, emphasising the importance of family financial socialisation in fostering responsible financial practices among young people.
The Association of the Low-Income Housing Tax Credit Program and Intimate Partner Violence Related Emergency Department Visits
Authors: Shanahan Meghan E. , Austin Anna E. , Durrance Christine P. , Martin Sandra L. , Runyan Desmond K. , Runyan Carol W.
Published: September 2024

Purpose

To examine the association of increasing access to affordable housing through the Low-income Housing Tax Credit Program with non-fatal intimate partner violence (IPV) among women.

Methods

We used 2005–2014 data from the State Emergency Department Database (SEDD) and the low-income housing tax credit (LIHTC) program, a federal program providing tax incentives to support the construction of affordable housing units, to examine the association between the number of LIHTC units available and rates of IPV-related emergency department visits. We conducted generalized linear regression comparing state-years with above the median number of LIHTC units (> 28 units per 100,000 population) to those with below the median number of units (≤ 28 LIHTC units per 100,000 population). We adjusted the analyses for time-varying indicators of state median household income, percent population by race/ethnicity, percent population unemployed, violent crime rate, refundable Earned Income Tax Credits, maximum Temporary Assistance for Needy Families benefit for family of 3, and minimum wage.

Results

We found that greater availability of LIHTC units (> 28 vs. ≤ 28 LIHTC units per 100,000 population) was associated with decreased rates of IPV-related emergency department visits among women (RR 0.90; 95% CI 0.84, 0.97).

Conclusions

Increasing access to affordable housing, an important social determinant of health, through the LIHTC program may be an important component of strategies to prevent IPV severe enough to warrant an ED visit.
Integrating philosophy and psychology to enhance creativity and innovation in entrepreneurship: the W.O.M.B. model
Authors: de Almeida Leite Eduardo Manuel , Audretsch David , Leite Ana
Published: September 2024

This study explores the intersection between philosophy, psychology, and entrepreneurship to promote creativity and innovation through the W.O.M.B. model (Well-being, Open-mindedness, Mindfulness, and Brilliance). Utilizing insights from Plato, Spinoza, Schopenhauer, and Winnicott, the model integrates classical theories with contemporary practices. The methodology includes an extensive literature review and the practical application of the model in educational and organizational contexts. The results indicate that the W.O.M.B. model can enhance the generation of innovative ideas and employee satisfaction. Practical implications include creating work environments that foster creativity, implementing mindfulness practices, and providing continuous emotional support to employees.