bluuebunny/crossref_metadata_2025 huggingface dataset:
Political Stability and Performance of Financial Institutions in Pakistan
Authors: Usman Muhammad , Ali Shoukat , Ul Hassan Waseef , Irfan Muhammad , Nadeem Ayyaz , Aslam Shoaib
Published: March 2024

The purpose of the present study is to analyze the impact of political stability on the performance of financial Institutions in Pakistan. This is the first study in the context of Pakistan that analyzes the performance of financial institutions during the period of political stability. The study's sample period was from 2008 to 2017 because, for the first time in Pakistan, two pure political governments completed their electoral term since the country's independence in 1947. The data is collected from the balance sheet analysis provided by the State Bank of Pakistan on its official website. For the data analysis, the study used the CAMEL analysis technique. The CAMEL analysis technique was also used by the IMF in 2020 to analyze the performance of underdeveloped and developing countries of the world. The results show that the performance of locally owned financial institutions (MCB Bank, United Bank Limited, and Allied Bank) in Pakistan increased during this period. Still, foreign-owned bank's performance is not good even if they cannot fulfill the minimum requirement established by the State Bank of Pakistan. The results contribute to the efficiency theory of financial institutions. Further, the study suggests that the researchers can test the significance of the results by changing sectors to confirm, modify, accept, or reject the results.
Exploring Eco-tourism Treasure of North-eastern States of India: A Sustainability Perspective
Authors: Chaudhury Dr. Suman Kalyan , Sarkar Dr. Sukanta , Patra Dr. Manaswini
Published: March 2024

The North-eastern states of India are blessed with beautiful natural landscapes, flora and fauna, folk music, mountains, mysterious clouds, cuisines, and tribal culture, making it unique for eco-tourism. The region has enormous scope for the growth of eco-tourism, with many wildlife sanctuaries and national parks, local arts and crafts, and fairs and festivals that can attract more tourists from home and abroad. This beautiful region abounds with adventurous activities like jungle safari, trekking, pilgrimage tours, mountaineering, tea garden tours, and ornithological tours are also available. However, transportation, accessibility, security threats, tourist facilities, hygienic food, accommodation, tourist information systems, system of permission, and brand image are the basic challenges before its tourism sector. Through a descriptive analysis, this paper discusses the opportunity and scope of sustainable eco-tourism in the North-Eastern states of India.
Genocide and Ecological Ruin in Amitav Ghosh’s The Nutmeg’s Curse: Parables for a Planet in Crisis
Authors: Sharma Kamal
Published: March 2024

Writing against the backdrop of the global pandemic of COVID- 19, Amitav Ghosh in his latest non-fiction text The Nutmeg’s Curse: Parables for a Planet in Crisis (2021), traces the contemporary planetary crisis back to a historical event popularly known as the Dutch Massacre that occurred in 1621. This massacre resulted in the ruthless exploitation of humans and the natural world by Western imperialism. Ghosh observes that the Banda islands were rich sources of nutmegs and this is the reason why Bandalese was attacked by European settlers to own nutmeg plantations. Dutch officials viewed that there could be no trade without war. The remaining Bandalese who survived the massacre went towards the forests to hide and started living with the spirits of woods, animals, and nature. For Bandalese, nature, as Carolyn Merchant claims, was a mother. The trade and business that the European settlers started along with the genocide of Bandalese continued in different forms and prepared a ground for the ecological crisis. The current predicament is the outcome of a mechanical view of the world in which nature is viewed as a resource for humans to exploit for their purposes. Drawing on the concepts of ecological theorists, this paper claims that the entire relationship of humans to non-human kind such as rivers, mountains, woods, animals, and the spirits of land should be based on reciprocity, ethics, and egalitarian concepts. The transfer of nutmeg from the original islands to the economic centers reveals a wider colonial mindset that justifies the exploitation of the entire ecology, which continues to lead to geopolitics, and functions as a source of planetary crisis. As the paper is qualitative, the ecocritical perspective has been applied to the primary text to conclude that the environmental crisis, seen or unseen, is rooted in colonial practices and capitalism.
The Influence of Digital Marketing Content on Purchase Intention Mediated by Trust Variables in Erigo Fashion Products
Authors: I Ilmi Nati , Wiryawan Driya , Asri Siti Ambarwati Dwi
Published: March 2024

The development of social media, e-commerce platforms, and online advertising technology has opened new opportunities and transformed the way companies interact with consumers. Digital marketing has evolved beyond being merely a promotional tool; it also significantly influences overall purchasing decisions. This research aims to examine the impact of digital marketing content on purchase intention, mediated by the variable of trust. The study's population consists of individuals who have viewed Erigo's marketing content. Using a non-probability sampling method to determine the sample size, 100 respondents were selected. As a quantitative study, primary data were collected through the distribution of questionnaires using Google Forms. The data were analyzed descriptively using SEM PLS software. The research findings indicate that digital marketing content influences trust, trust affects purchase intention, and digital marketing content does not directly impact purchase intention. This signifies that trust, as a mediating variable, plays a crucial role in the relationship between these variables.
Improving the Profitability of Public Transport by Daily Forecasting of Passenger Loads and Bus Trip Distribution
Authors: Siarhei Azemsha
Published: March 2024

The degree of utilization of passenger vehicle capacity affects the economic component of public transport operation. This is due to the fact that it depends on the number of passengers transported, as well as on the capacity of the passenger vehicle used for transportation. One of the tasks formulated in the state program of transport development of the Republic of Belarus is to achieve full self-sufficiency of public transport operation. One of the ways to achieve this goal can be maximizing the degree of use of passenger vehicle capacity by ensuring its compliance with the existing parameters of passenger flow. In this paper, based on the values of passenger flows in one of the cities of Belarus, obtained as a result of field observations in 2019 and 2024, we calculate an indicator that assesses the degree of utilization of passenger vehicle capacity, the factors that determine it, and the regularities of its change. Based on such calculations, the feasibility of creating a new public transport management technology based on daily forecasting of passenger traffic and distribution of passenger vehicles of different capacity to the routes taking this into account is shown.
Global Markets and Tech: Navigating Consumer Dynamics
Authors: Pasupuleti Murali Krishna
Published: March 2024

Abstract: This book chapter, titled "Global Markets and Tech: Navigating
Consumer Dynamics," delves into the intricate relationship between technological
advancements and their profound impact on global consumer markets. It explores how
digital transformation, through the advent of e-commerce, mobile technologies, and
social media, has reshaped consumer behaviors and expectations worldwide. The chapter
examines the role of emerging technologies such as artificial intelligence (AI), the
Internet of Things (IoT), and blockchain in personalizing consumer experiences and
enhancing market efficiencies. It also addresses the challenges and opportunities
businesses face in adapting to these rapid changes, emphasizing the importance of
agility, ethical considerations, and a consumer-centric approach for success in the
global marketplace. The discussion extends to the ethical implications and policy needs
that arise from technology-driven consumer dynamics, underscoring the significance of
privacy, data security, and bridging the digital divide. The chapter concludes by
offering insights into future consumer trends influenced by technological innovation and
global market shifts, highlighting the potential impacts of virtual reality, augmented
reality, and the metaverse on consumer markets. Through a comprehensive analysis, this
chapter provides valuable perspectives for businesses, policymakers, and scholars
interested in understanding and navigating the evolving dynamics of global consumer
behavior in the digital age. Keywords/Index Terms: Global Markets,Consumer
Dynamics,Technological Advancements,Digital Transformation,E-commerce,Mobile
Technologies,Social Media,Artificial Intelligence (AI),Internet of
Things(IoT),Blockchain Technology,Consumer Behavior,Personalization,Ethical
Considerations,Data Privacy,Digital Divide,Virtual Reality (VR),Augmented Reality
(AR),Metaverse,Market Segmentation and Predictive Analytics.
Neuromarketing en empresas publicitarias. Estudio de los cuadrantes de Herrmann
Authors: Ulloa Romero Yuri Vladimir
Published: March 2024

In this article about neuromarketing, an analysis is carried out of the predominance of the brain in consumers between 20 and 35 years old in the southern area of ​​the city of La Paz, as a potential market to carry out market studies aimed at advertising companies. The study carried out is quantitative, non-experimental and transectional and the data collection technique was the survey. The results of the research show that a significant percentage of consumers between 20 and 35 years old in the southern area of ​​the city of La Paz present a cerebral predominance governed by their inclination to make purchases intuitively and emotionally, which makes it possible for neuromarketing studies will be carried out in the future by advertising companies. It is concluded that the study of Herrmann's quadrants in neuromarketing is a useful tool to improve communication and persuasion of advertising companies, as well as to generate value and satisfaction in consumers.
La psoriasis y la calidad de vida del paciente en Iquitos, Perú
Authors: Zamora Perea Hugo Percy
Published: March 2024

The objective to determine the relationship of Psoriasis with the quality of life in patients of the Loreto regional hospital in Iquitos, Peru. Methodology: Confirmatory research with non-experimental design, cross-sectional field; the non-probabilistic sample of 80 patients with psoriasis, older than 18 years, who are cared for at the Regional Hospital of Loreto and agreed to participate in the study. Results: 67.5% of the patients present a severe level of severity and 86.3% present a moderate level of magnitude of the disease. The severity of psoriasis is significantly (0.01) related to quality of life in a degree (0.28) of moderate correlation. The magnitude of psoriasis is verified to be not significantly related (0.43) with quality of life by one degree (0.08) with almost zero correlation. Conclusion. The quality of life of patients with psoriasis and the degree of affectation has a moderate correlation; psoriasis minimizes and deteriorates the quality of life of the person, although this can generate a coping mechanism to live in society.
Implementation of A Contemporary Model Between Trading Volume, Bid-Ask Spreads, And Stock Return Volatility (Case Study : The Business-27 Index)
Authors: Andi Agung Andik , Zaqiyah Arfatuz , Rozikin Muhammad , Wafa Moh. Shohibul , Nuha Agusyarif Rezka
Published: March 2024

Artikel ini memuat analisis hubungan antar variabel perdagangan saham yakni volume perdagangan, bid-ask spreads, dan volatilitas return saham dalam ruang lingkup dua hipotesis utama yakni the mixture of distribution hypothesis (MDH) dan the sequential information arrival hypothesis (SIAH). Hasil perhitungan mengidentifikasi bahwa pada sebagian besar saham terdapat hubungan kontemporer positif antara volume perdagangan terhadap voltilitas return tidak cukup bukti mendukung teori MDH.
Impact of Online Sales on The Sustainability of Conventional Traders in Sekupang District, Batam City
Authors: Harahap Diana Sari , Betricia Jesicca , Rahayu Sri , Jonathan Steven , Sihombing Urianto , Handayani Vitri Aprilla , Handayani Lilies
Published: March 2024

Pedagang konvensional adalah individu atau kelompok yang sedang berada di suatu lokasi terbuka terjadi kegiatan transaksi jual beli dengan memungkinkan proses tawar-menawar. Dengan zaman yang semakin modern keberlanjutan pedagang konvensional dapat dipengaruhi dengan adanya penjualan online. Oleh karena itu penulis tertarik untuk melakukan penelitian untuk mengetahui seberapa besar pengaruh adanya penjualan online terhadap keberlanjutan pedagang konvensional di kecamatan Sekupang kota Batam. Metode penelitian yang digunakan adalah metode kuantitatif dengan teknik pengambilan data yaitu data primer melalui kuisioner. Metode analisa data dilakukan dengan menggunakan uji statistik regresi linear sederhana. Berdasarkan analisis data yang telah dilakukan diketahui adanya penjualan online mempengaruhi keberlanjutan pedagang konvensional di kecamatan Sekupang kota Batam.
Life Expectancy Prediction Using Decision Tree, Random Forest, Gradient Boosting, and XGBoost Regressions
Authors: Chairunisa Ghevira , Najib Mohamad Khoirun , Nurdiati Sri , Imni Salsabila F. , Sanjaya Wardah , Andriani Rizka D. , Henriyansah  , Putri Renda S. P. , Ekaputri Dhea
Published: March 2024

Angka harapan hidup menggambarkan rata-rata lamanya waktu seseorang hidup sejak lahir di dunia. Angka harapan hidup menjadi salah satu aspek dalam menentukan indeks pembangunan manusia. Semakin tinggi Angka harapan hidup maka akan semakin tinggi nilai IPM. Tujuan penelitian ini adalah memprediksi angka harapan hidup melalui model yang paling akurat dengan menggunakan model decision tree regression, random forest regression, gradient boosting regression, dan XGBoost regression, serta analisis variabel penjelas yang paling mempengaruhi angka harapan hidup. Data yang digunakan dalam penelitian ini adalah dataset Global Country Information Dataset 2023. Data diperoleh dari situs Kaggle. Berdasarkan analisis diperoleh bahwa model random forest regression menunjukkan kinerja yang lebih unggul dalam memprediksi hasil, yang ditunjukkan dengan nilai RMSE yang lebih rendah dan nilai R² yang lebih tinggi. Kematian bayi dan rasio kematian ibu secara konsisten diidentifikasi sebagai prediktor yang signifikan di semua model, sedangkan populasi merupakan prediktor yang kurang memprengaruhi angka harapan hidup.
PENGARUH PENGGUNAAN MEDIA PAPAN KOTAK DALAM MENINGKATKAN HASIL BELAJAR MATEMATIKA PADA MATERI SATUAN PANJANG
Authors: Wijayanti Arini , Firdaus Andi Mulawakkan
Published: March 2024

The problem in this research is whether the checkerboard media affects improving mathematics learning outcomes in long unit material for class III UPTD students at SDN 104 Inpres Makkaraeng. This type of research is experimental research. The population in this study were all class III students at UPTD SDN 104 Inpres Makkaraeng. Meanwhile, the researcher used a random sample for sampling, namely class III a with 23 students as the control class and class III b as the experimental class. The data collection techniques used by researchers are 1) Observation, 2) Pre-test and post-test given to students to determine student learning outcomes, and whether the results have improved or not. The results of the study are: In the control class, it can be seen that student learning outcomes have improved. The pretest result of the control class (III a) students was that students got an average score of 48.91. In the posted results of control class students (Class III a), the average data was 73.91 and was included in the category of incomplete KKM. The pretest result of experimental class students (III b) is that students get an average score of 53.21. As for the posted results of control class students (Class III b), the average data was 85.86. So the checkerboard media had an effect in improving the results learn mathematics in length unit material. The hypothesis put forward, namely, that the checkerboard media affects improving mathematics learning outcomes in long unit material for class III UPTD SDN 104 Inpres Makkaraeng, has been proven to be true.
PENGGUNAAN MEDIA PEMBELAJARAN SEDOTAN (DRINGKING STRAWS) DAN KANTONG DALAM MENINGKATKAN HASIL BELAJAR
Authors: An Nisa Winni
Published: March 2024

In learning mathematics, teachers only use book media and lecture methods, namely the teacher explains then students take notes. Especially in the numerical material, the teacher has not used the maximum learning media, therefore making students unable to understand the numerical material as a whole. As for this research, formulating the problem "The use of media straws (Drinking Strawss) and number bags in improving mathematics learning outcomes in class IV UPTD SDN 104 Inpres Makkaraeng This type of research is a class action research (PTK). This class action research is an observation of learning activities in the form of an action, which is deliberately raised and occurs in a class together. The action is given by the teacher or with direction from the teacher carried out by students. During the implementation of cycle 2, observations on students were carried out using a previously prepared format or student observation sheet, which aims to determine the extent to which the Numbers Bag media can improve student learning outcomes. Reflection, At this stage of cycle 1, there were several students whose scores were still below the KKM, because students also did not fully understand the media directly exemplified by the researcher. In cycle 2, student learning outcomes have improved better than in cycle 1. This can be seen from the results of the post-test given as a benchmark for assessing the final results of the application of the number bag media on the learning outcomes of grade IV students. It is concluded that the use of straw media in mathematics learning can improve the learning outcomes of grade IV students of UPT SDN No.141 Makkaraeng. This is evidenced by the activities of grade IV students in learning mathematics using straw media have increased. This can be seen from the percentage of student activity in cycle I of 18,5% and increased by 62% to 81% in cycle II (3) the learning outcomes of grade IV students at UPT SDN No. 141 Inpres Makkaraeng on mathematics learning have increased from cycle I and cycle II. In cycle II, student learning outcomes have reached the success indicator.
The Influence of Tangible, Reliability, Responsiveness, Assurance, and Emphaty on Customer Satisfaction at PT PLN Persero
Authors: Tuzahra Siti Mutia , Megawati Megawati
Published: March 2024

This study aims to analyze the effect of Tangible, Reliability, Responsiveness, Assurance, and Empathy on Customer Satisfaction at PT PLN Persero. This study uses quantitative methods and a sample of 100 respondents. Methods of data analysis using non-probability sampling, purposive sampling and multiple regression with the SPSS ver 26 test tool. Based on the results of the study, it shows that only the Reliability variable has a partial effect on Customer Satisfaction at PT PLN Persero and the Tangible, Responsiveness, Assurance, and Empathy variables have no partial effect on Customer Satisfaction at PT PLN Persero. Simultaneously each variable, namely Tangible, Reliability, Responsiveness, Assurance, and Empathy has an positive effect on Customer Satisfaction at PT PLN Persero.
Geles poliméricos. 1. algunos conceptos básicos y reología de geles
Authors: Echeverría Coro , Mijangos Carmen
Published: March 2024

Los geles poliméricos están constituidos por polímero y disolvente y poseen tanto las propiedades cohesivas de los sólidos como las propiedades de transporte de los líquidos. Esta dualidad permite modular la actividad de los geles de forma controlada y elucidar aspectos estructurales de los mismos. Los geles abarcan un gran espectro de diferentes polímeros (sintéticos y de origen natural), disolventes (el agua es el más común: hidrogeles), tamaños (macro-, micro- y nanogeles) y propiedades específicas, muy atractivas de cara a sus aplicaciones. El estudio de las propiedades viscoelásticas y la aplicación de distintos modelos permite conocer su organización estructural. Los geles han demostrado su utilidad como sistemas eficaces de almacenaje/incorporación de disolventes y otros componentes, liberación de fármacos y en hipertermia magnética, entre otros. Este trabajo resume muy brevemente algunos conceptos y se centra en las propiedades reológicas donde se han recogido los modelos y teorías más relevantes aplicadas tanto a geles como a microgeles poliméricos.
CONSENSUS AS A TECHNOLOGY FOR MANAGING CHANGES IN TERRITORIAL COMMUNITIES OF UKRAINE
Authors: PETRENKO Viktor , MARYCH Volodymyr , SMOLII Volodymyr
Published: March 2024

The article demonstrates that a key condition for the development of territorial communities (TC) formed in the process of decentralization in Ukraine is the ability of their local self-government bodies to ensure the social consent of their population in the communities regarding the purpose, goals and objectives of joint development with the observance of social justice for all members of the communities. However, due to the fact that most of the known recommendations on the management of TC activities are focused only on the personnel of local self-government bodies of the TC, and the population as a plurality of members of households, personnel of small and medium-sized businesses, institutions and organizations, various associations of citizens to Recently, they have not been considered as participants in the management process, the methods of their involvement in this process with the effective use of the intellectual resources of the community remain insufficiently studied.

Based on the analysis of well-known models of management of the behavior of human resources in change processes, the expediency of their combined use to manage the achievement of consensus by both management bodies and the population of the TC in the processes of making, making and implementing decisions on important issues of its socio-economic development is substantiated. A combined formula of the energy of change with characteristic conditions for reaching a consensus, formed by the results of managerial influences, recommended for implementation by managers and functionaries of the governing body, is proposed.
THE ARCTIC: THE STRUGGLE FOR RESOURCES AND INFLUENCE IN THE REGION
Authors: SHARYI Viacheslav
Published: March 2024

Modern climate changes caused by the processes of global warming are clearly reflected in the geopolitical interests of various states of the world in relation to the Arctic region. Accordingly, the relevance of the study of this issue is caused by the formation in the last decade of a number of opportunities that may be open to a state that will establish its influence in the Arctic. This is due to a combination of economic and political advantages expressed in the extraordinary amount of resources that characterize this region, the development of rational sea routes, the satisfaction of commercial goals and even the protection of the sovereignty of coastal countries. Thus, the purpose of the work was to define the Arctic as a political arena, in particular, to reveal the interests and plans of various countries regarding its territory and resources. For this, the research used the method of analysis and synthesis, comparison, deduction, generalization, as well as historical. As a result, it was established that active climatic changes in the world cause the formation and development of new economic opportunities in the Arctic. Accordingly, the role of this region was determined for such countries as Canada, Russia, United States of America, Norway, Denmark, Iceland, Sweden and Finland. It was possible to establish that their interests are to a greater extent caused by the desire to control the operation of the Northern Sea Route. In addition, the work described the advantages of the Arctic region, which describe the priority of establishing control over this territory by the relevant state. In particular, it is beneficial for the development of economic activity, the protection of the territories of coastal countries, it is characterized by a significant number of deposits of natural resources and other minerals, as well as wide transit opportunities. Thus, it was proved that it is appropriate to consider the Arctic as a socio-cultural, ethnic, socio-economic, geopolitical space around the North Pole, the resources of which provoke world states to compete with each other. The practical value of the work is revealed in the possibility of using its results for further scientific research, as well as educational material for those studying the Arctic and its role in international relations.
A COMPARISON OF THE THREE TECHNIQUES IN PREDICTING BREAKING STRENGTH OF COTTON AND BLENDED WOVEN FABRICS
Authors: Berkhan Kastaci Bilge , Özek Hikmet Ziya , Özhan Erkan
Published: March 2024

With the development of technology, artificial intelligence applications in the textile industry are increasing. The uses of these methods present very good results in cases where statistical methods are lacking in the accurate evaluation and analysis of the past data of the enterprises and the estimation of their future situations. In this study, some models are developed, based on this relationship, to estimate the breaking strength of cotton woven fabrics and polyester/viscose blended woven fabrics separately. Breaking strength is considered one of the most important performance characteristics of woven fabrics. It is mostly determined by the structural elements of the fabric. Multiple linear regression, artificial neural networks and random forest algorithms are employed to perform statistical and stochastic analyses on these elements by using industrial data. A total of 147 fabric data sets in warp and weft directions were used for training and test data in cotton fabrics, and 53 fabric data sets in warp and weft directions in blended fabrics. Appropriate models are generated by using Minitab Statistics and Matlab software. Yarn linear densities, yarn production methods, twist amounts, fabric densities, crimp ratios, unit area weights, various weave factors and fabric structure factors were selected as variables of the models estimating the breaking strength of fabrics in both warp and weft directions. These factors were included in the models separately, and the subset that gave the best results was selected and the models were revised. For the three models created, it was seen that the regression models and models based on artificial neural networks performed well in both cotton fabrics and blended fabrics, while random forest algorithms were not very accurate in estimating the breaking strength.
Flexible and Stretchable Printable Conductive Inks for Wearable Textile Applications
Authors: Baysal Gülçin
Published: March 2024

As wearable electronic devices become increasingly integrated into our daily routines, there is a growing demand for soft, flexible, and comfortable devices that can seamlessly deliver electronic functionalities. Electronic textiles (e-textiles) combine the electronic capabilities of devices such as sensors, actuators, energy storage, and communication tools with the comfort and flexibility inherent in traditional textiles. The rising interest in E-textile and sensor applications has thrust the field of printed electronics (PE) into the spotlight. Printed electronics is a rapidly expanding technology that allows the construction of electronic devices on affordable, flexible substrates, including paper and textiles. This is achieved through printing techniques, such as screen printing, 3D printing, gravure printing, offset printing, flexography, and inkjet printing, which are traditionally used in various industries like graphic arts, textiles, and polymers. This paper provides a comprehensive overview of printable conductive inks, with a focus on their role in designing textile-based wearable conductive devices for E-textile applications. Within this scope, it was examined the properties of conductive inks, presented the various printing methods used to fabricate wearable textile materials for potential use in wearable textile devices, and analyzed their performance characteristics. Lastly, it was addressed the key challenges faced in this field and identify future research directions. The aim of this paper is to contribute to the advancement of cost-effective functional conductive inks and formulations, promoting their integration into E-textile applications.
VERIFICATION AND ASSESSMENT OF THE MEASUREMENT UNCERTAINTY OF THE HPLC METHOD FOR DETERMINING THE AMOUNT OF HISTAMINE IN FISH AND FISHERY PRODUCTS
Authors: ANIČIĆ Jelena , GOLIĆ Milijana , PEĆANAC Biljana
Published: March 2024

The aim of the study is to present the experimental results obtained during the verification of the HPLC method for determining the histamine content in fish and fishery products for three types of fish and fishery products and to estimate measurement uncertainty of the method. The method for determining the amount of histamine in fish and fishery products is verified according to BAS EN ISO 19343:2017. The following parameters of the verification method were evaluated: influence of the matrix/linearity, limit of quantification, accuracy and precision. Measurement uncertainty of the method was estimated for three types of fish (tuna, mackerel and sardines). Linearity was confirmed in the concentrations range from 0 mg kg-1 to 500 mg kg-1 with correlation coefficients from 0.9925 to 0.9999. The limit of quantification for all three types of fish is 10 mg kg-1. The accuracy was evaluated by analyzing the control materials through recovery and the average value is 96.61%. The precision was evaluated in terms of repeatability and reproducibility at three concentration levels for three types of fish and was expressed as the repeatability limit r and the reproducibility limit R. The reproducibility limits R for tuna are 15.96 to 24.89%, for mackerel 12.80 to 23.04%, and for sardines from 10.25 to 32.17%. The measurement uncertainty was estimated at three concentration levels 25 mg kg-1, 100 mg kg-1 and 220 mg kg-1 and was 17.78 mg kg-1, 11.40 mg kg-1 and 13.88 mg kg-1 for tuna, 16.46 mg kg-1, 12.56 mg kg-1 and 9.14 mg kg-1 for mackerel and 22.98 mg kg-1, 12.70 mg kg-1 and 7.32 mg kg-1 for sardines. The obtained results of the verification parameters are in accordance with the prescribed and recommended acceptance criteria, and confirm that the test method is sufficiently reliable and the laboratory can use it in routine work.
ВЕКТОРСКЕ ЗООНОЗЕ КОЈЕ МОГУ ДА УГРОЗЕ РЕГИОН ЈУГОИСТОЧНЕ ЕВРОПЕ
Authors: ВАЛЧИЋ Мирослав , ВАСИЋ Ана , НЕДИЋ Драго
Published: March 2024

Први Факултет ветеринарске медицине основан је у Француској (Лион) 1762. године, у намери да се спрече циклични таласи појављивања куге говеда почетком 18. века у Европи. Три века касније сведоци смо да инфективне болести и у оквиру њих зоонозе, не само да не могу да се искорене у регионима где се појављују ензоотски већ и да њихово ширење представља реалну претњу и за удаљене регионе света. Посебан сегмент науке о заразним болестима чини група зооноза које се преносе векторима. Ради се о бројним инфективним болестима животиња и људи, чији се узрочници преносе инсектима и артроподама при чему се у неким случајевима, вектори појављују као прави домаћини и резервоари изазивача зооноза. До пре две деценије појава грознице Западног Нила (West Nile fever) у регионима света где се ова зооноза појаљивала ензоотски и ендемски (на пример Афрички континент), није заокупљала пажњу епизоотиолога и епидемиолога. Међутим, ова заразна болест је у протеклих двадесетак година у нашем региону изазвала обољевање значајног броја људи, а у неким случајевима исход је био фаталан. Аналогно примеру грознице Западног Нила, може да се претпостави да већи број зооноза које се преносе векторима, практично „куца на врата“ региона југоисточне Европе. Тај регион може да се сматра пуфер зоном где са стране југа и истока постоје мање или више удаљени региони где се ензоотски појављују до сада „егзотичне“ зоонозе и из ког правца може да се очекује продор вектора, а са њима и изазивача инфективних обољења које преносе. Потенцијал трансмисије векторских зооноза се пре свега односи на обољења која преносе инсекти и артроподе. У случају инсеката могао би да се очекује нагли продор на пример, грознице Рифтске долине (Rift valley fever), инфекције Chikungunya вирусом (Chikungunya), јапанског енцефалитиса (Japanese encephalitis) или жуте грознице (Yellow fever). Борба са оваквим зоонозама пре свега треба да се заснива на контроли вектора. За неке од ових зооноза већ постоје развијене вакцине за употребу у хуманој (на пример Јапански енцефалитис) и ветеринарској (на пример грозница Западног Нила) медицини. У случају да се ради о зоонозама које се преносе артроподама (Конго-Кримска хеморагична грозница, крпељски енцефалитис), очекује се да се зараза шири полако али стабилно, при чему већи значај имају дијагностичка испитивања и примена метода присмотре и надзора присуства у врстама животиња које могу да буду индикатори присуства обољења. У раду су приказани основни механизми у трансмисији векторских зооноза као и поједине заразне болести које се преносе инсектима и артроподама, а које имају значајан потенцијал да угрозе регион југа и истока Европе.
Features of the formation of patriotism in the course of teaching humanitarian academic disciplines of the Department of Psychology and Pedagogy of the Krasnodar University of the Ministry of Internal Affairs of Russia
Authors: Kipreev Sergei Nikolaevich
Published: March 2024

This author discusses the features of the research of the sense of patriotism among the cadets of the educational organization of the Ministry of Internal Affairs, conducted at the Department of Psychology and Pedagogy of the Krasnodar University of the Ministry of Internal Affairs of Russia. The purpose of the study was to determine the effectiveness of the introduction of methods to supplement the content of academic disciplines in the educational process. For this purpose, the author conducted experimental work on the formation of a sense of patriotism among police cadets at the Department of Psychology and Pedagogy. The article describes the types of information elements directly introduced into the content of educational material or indirectly used during training sessions, reveals the specifics of their use for patriotic education. The specifics of the education of patriotism in the course of teaching humanitarian academic disciplines are revealed. The description of promising areas of further research on the topic of education of patriotism is given, and recommendations for improving the system of patriotic education in a departmental university are proposed. The transformation of the content of humanitarian disciplines is described in order to form a sense of patriotism among cadets. The researcher gives the author's typology of the feeling of patriotism, actualizes the question of the need to improve the process of patriotic education in new information and political conditions. The paper managed to show the peculiarities of the formation of patriotism in educational practice, in the process of teaching academic disciplines of the humanities cycle at the Department of Psychology and Pedagogy in the educational system of the Ministry of Internal Affairs of Russia.
Integrating molecular docking and molecular dynamics simulations to evaluate active compounds of Hibiscus schizopetalus for obesity
Authors: Yuli Astuti Purnama Dewi , Fadilah Fadilah , Promsai Saran , Bahtiar Anton
Published: March 2024

The group screened and identified the content of Hibiscus schizopetalus by protein–protein interaction, molecular docking, and dynamics as a potential therapy for obesity through pancreatic lipase (PNLIP) as a protein target. First, the group collected all active ingredients of H. schizopetalus from an online database [http://www.knapsackfamily. com/ and http://ijah.apps.cs.ipb.ac.id/] to identify and isolate active compounds. The 3-D structures and canonical of the active compound were taken from the PubChem database, and then all compounds were analyzed by pkCSM and Tox-Protox II to get pharmacokinetics and physical-chemistry properties. The protein target of obesity was identified using the Open Target Platform. After the protein targets of plant extract and obesity were collected, the group analyzed them using Cytoscape. Protein–protein interaction was analyzed using String, Gene ontology, and KEGG pathway. Virtual screening was done by Pyrx software, and visualization was done by Discovery Studio Biovia, proceed by molecular docking using AutoDockTools-1.5.7, and finally, molecular dynamics (MDs) was done using YASARA software. The group collected 70 compounds from a research journal and found 196 protein targets. The target of obesity was 165 protein targets. The 196 protein targets of H. schizopetalus and 165 protein targets were analyzed and merged using Cytoscape and 11 proteins targeting H. schizopetalus and obesity. After that, the group analyzed which compound of H. schizopetalus affected 11 protein targets by Pyrx with the highest binding affinity. PNLIP has the highest binding affinity compared to other proteins, so the group analyzed this PNLIP protein with its relationship to obesity. The group found that three proteins that work on PNLIP are beta-sitosterol, kaempferol, and gallocatechin gallate. After docking these three proteins, the group found only one active compound has the highest binding affinity compared to the commercial drug Orlistat. Then, the process ended by performing MDs of the active compound as a candidate drug for anti-obesity. In this study, the group found that gallocatechin gallate, as an active compound of H. schizopetalus, can inhibit PNLIP enzymes for obesity therapy by bio-informatics study.
Anticancer activity of ex vitro established Achillea thracica Velen. water extracts
Authors: Koleva Vanya , Dragoeva Asya , Dimitrova Zheni , Toshkova Stefani , Rogova Mariya
Published: March 2024

Ex situ conservation of Bulgarian endemic species Achillea thracica offers a chance for development of a new antitumor drug. This study aimed to evaluate the anticancer effects of water extracts of ex vitro established A. thracica grown in Bulgaria against fibrosarcoma cells. Our preliminary study determined the cytotoxicity of hot and cold water extracts using Triticum root elongation test and Allium cepa assay. In vitro cytotoxicity and pro-apoptotic activity of hot extract (HE) were estimated using HT1080 cell line fibrosarcoma cells. The change in the cell number, the cell viability, and the cell population growth determined cytotoxicity. The pro-apoptotic activity was assessed by the score of cell nuclei with morphological changes. The result of the root elongation test showed that the HEs exerted a stronger inhibitory effect than the cold extracts (CEs). Respectively, the EC50 value of the hot water extract is 9.85 g/l and of the CE – 12.71 g/l. The extracts tested at a concentration equal to ½ ??50 and EC50 values showed a significant mitodepressive effect on A. cepa meristematic cells. The in vitro tests revealed a significant negative impact on cancer cell viability and a promising pro-apoptotic activity of hot water extract.
In silico design of new ketorolac bioisosteres as anti-inflammatory agents
Authors: Gamarra-Sánchez César D. , Rodriguez Cristhian N. -Silva , Cordova-Muñoz Angella , Asmad-Cruz Lucero , Silva-Correa Carmen R. , Torre Víctor E. Villarreal-La
Published: March 2024

Nonsteroidal anti-inflammatory drugs (NSAIDs) are over-the-counter drugs and one of the most widely used pharmacological groups worldwide, their chronic use is limited due to their adverse effects, with gastrointestinal effects being the most relevant. Ketorolac is one of the most consumed NSAIDs worldwide, the use of which has been increasing in the treatment of acute and chronic pain; however, its use has been limited by its gastrointestinal adverse effects. Modifications in the structure of ketorolac may help the search for new chemical entity candidates for anti-inflammatory analgesic drugs with less gastric effects. Forty-two ketorolac-derived bioisosteres were designed, using in silico techniques, their physicochemical parameters (molecular weight, polar surface area, and lipophilicity) were determined with SwissADME, the Way2Drug server was used to predict the activity, a 2D quantitative structure-activity relationship (QSAR) analysis was performed to quantify the anti-inflammatory activity of the derivatives, using the ChemBL database and the R language; and the molecular modeling for the prediction of the positioning in the active site and the ligand efficiency (LE), for which the 5IKR file of the protein data bank database was used, and the molecular coupling was carried out under the parameters of AutoDock Vina. Of the 42 ketorolac derivatives, 12 molecules demonstrated good predictive oral absorption, of which only 8 molecules showed less gastro-injurious effects with Way2Drug and, under 2D QSAR analysis, 3 demonstrated excellent anti-inflammatory activity. Using the molecule modeling techniques, the LE was verified, and it was determined that molecules 32 and 34 adequately inhibited the cyclooxygenase-2 enzyme; however, the pKa of molecule 34 is not greater than that of ketorolac, molecule 32 being the one that meets with all the parameters proposed in the present study, so it would be a candidate to continue in preclinical phase studies to corroborate the findings made in this investigation.
The association of ACE gene polymorphism and serum ACE levels with diabetic nephropathy-a cross-sectional study
Authors: Pai Divya , Adiga Sachidananda , Suresh G. , Adiga Usha , Chaitra D. , Honalli Neha Martha
Published: March 2024

Diabetic nephropathy (DN) is the microvascular complication of type-2 diabetes that leads to end-stage renal disease. The angiotensin-converting enzyme gene that is a part of the renin-angiotensin-aldosterone system is considered one of the candidate genes responsible for the genetic predisposition of DN. To compare serum angiotensin converting enzyme (ACE) levels, the pattern of ACE gene polymorphism in patients with type-2 diabetes with or without nephropathy, to find the association between ACE gene polymorphism and various stages of DN, the association between serum ACE levels and various stages of DN. We enrolled 108 patients diagnosed with type-2 diabetes and 108 DN patients. Serum levels were estimated by ELISA and gene polymorphism was performed with gene sequencing. It was found that the serum ACE levels were higher in DN patients than in type-2 diabetics although the p-value was not significant. There was no significant association between serum ACE levels and various stages of nephropathy. The wild (GG genotype) distribution was more predominant in type-2 diabetic patients than in DN patients. There was a significant difference in the frequency of genotype with various stages of nephropathy and estimated glomerular filtration rate which was statistically significant (p = 0.0018). In summary, the study did not find a significant association between serum ACE levels and DN, nor did it observe a substantial impact of ACE gene polymorphism on serum ACE levels in DN patients. The findings also indicated that the ACE gene polymorphism might not have a direct influence on albuminuria stages. However, the wild-type genotype showed a trend toward protection against albuminuria development, while the carrier patients had a higher prevalence of severe albuminuria. Further research with larger sample sizes and longitudinal studies may provide deeper insights into the role of serum ACE levels and ACE gene polymorphism in the development and progression of DN.
Effects of noise and metabolic cost on cortical task representations
Authors: Stroud Jake Patrick , Wojcik Michal , Jensen Kristopher Torp , Kusunoki Makoto , Kadohisa Mikiko , Buckley Mark J , Duncan John , Stokes Mark G , Lengyel Mate
Published: March 2024

Cognitive flexibility requires both the encoding of task-relevant and the ignoring of task-irrelevant stimuli. While the neural coding of task-relevant stimuli is increasingly well understood, the mechanisms for ignoring task-irrelevant stimuli remain poorly understood. Here, we study how task performance and biological constraints jointly determine the coding of relevant and irrelevant stimuli in neural circuits. Using mathematical analyses and task-optimized recurrent neural networks, we show that neural circuits can exhibit a range of representational geometries depending on the strength of neural noise and metabolic cost. By comparing these results with recordings from primate prefrontal cortex (PFC) over the course of learning, we show that neural activity in PFC changes in line with a minimal representational strategy. Specifically, our analyses reveal that the suppression of dynamically irrelevant stimuli is achieved by activity-silent, sub-threshold dynamics. Our results provide a normative explanation as to why PFC implements an adaptive, minimal representational strategy.
More than just a simple barrier
Authors: Velazquez-Miranda Erandi , He Ming
Published: March 2024

Endothelial cell subpopulations are characterized by unique gene expression profiles, epigenetic landscapes and functional properties.
Advertisement design in dynamic interactive scenarios using DeepFM and long short-term memory (LSTM)
Authors: Zeng Lingling , Asif Muhammad
Published: March 2024

This article addresses the evolving landscape of data advertising within network-based new media, seeking to mitigate the accuracy limitations prevalent in traditional film and television advertising evaluations. To overcome these challenges, a novel data-driven nonlinear dynamic neural network planning approach is proposed. Its primary objective is to augment the real-time evaluation precision and accuracy of film and television advertising in the dynamic interactive realm of network media. The methodology primarily revolves around formulating a design model for visual advertising in film and television, customized for the dynamic interactive milieu of network media. Leveraging DeepFM+long short-term memory (LSTM) modules in deep learning neural networks, the article embarks on constructing a comprehensive information statistics and data interest model derived from two public datasets. It further engages in feature engineering for visual advertising, crafting self-learning association rules that guide the data-driven design process and system flow. The article concludes by benchmarking the proposed visual neural network model against other models, using F1 and root mean square error (RMSE) metrics for evaluation. The findings affirm that the proposed model, capable of handling dynamic interactions among images, visual text, and more, excels in capturing nonlinear and feature-mining aspects. It exhibits commendable robustness and generalization capabilities within various contexts.