bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Factors of New Vertebral Compression Fracture After Percutaneous Kyphoplasty or Vertebroplasty: A Retrospective Study of 752 Patients
Authors: Zhang Bo-bo , Song Zhong-wei , Wang Ying , Ren Zhi-wei , Yang Wei-zhou , Yang Yi-min
Published: November 2021

Summary Irregularly postoperative anti-osteoporosis treatment (AOT), number of treated vertebrae (NTV) ≥ 2, bone mineral density (BMD) ≤－3.0 SDs, body mass index (BMI) <18.5kg/m2 or BMI ≥ 24kg/m2, vertebral height loss ratio (VHLR)＞20% were strong risk factors associated with new vertebral compression fractures (NVCF) after percutaneous vertebroplasty or kyphoplasty (PVP/PKP) in patients with osteoporotic vertebral compression fractures (OVCF). There was no difference between NVCF occurred adjacent or remote after PKP/PVP intervention.Introduction NVCF have been connected to PVP/PKP surgery for patients with VCF. There are some debates about whether new vertebral body fractures are simply a result of the natural progression of osteoporosis or whether they should be regarded as a consequence of augmentation. We tried to investigate and identify the risk factors which may be relevant to NVCF after PVP/PKP surgery in OVCF patients.Methods The authors retrospectively analyzed the occurrence of NVCF in 752 patients treated with PVP or PKP for OVCF. Possible risk factors, such as age, gender, refracture time (RT), AOT, NTV, BMD, BMI, and VHLR, were assessed.All methods are carried out in accordance with relevant guidelines and regulations.Results Significant differences (P<0.05) were found between the NVCF and control groups with regard to AOT, number of treated vertebrae, BMD, BMI, and VHLR by univariate analysis. And irregularly AOT, NTV ≥ 2, BMD ≤－3.0 SDs, BMI < 18.5 kg/m2 or BMI ≥ 24kg/m2, VHLR＞20% were found to be the significant factors in multivariate analysis. To evaluate a direct and more precise effect of the procedures on untreated vertebrae, the NVCF group was subdivided into adjacent and remote fracture groups. All of factors have no significant difference between two subgroups.Conclusion In the current study, the incidence of NVCF after PVP/PKP is 9.58%. Irregularly AOT, NTV ≥ 2, BMD ≤－3.0 SDs, BMI <18.5kg/m2 or BMI ≥ 24kg/m2, VHLR＞20% were strong risk factors associated with NVCF after PVP/PKP in patients with OVCF. There was no difference between NVCF occurred adjacent or remote after PKP/PVP intervention and that might be the result of the osteoporosis itself. All of those should be addressed during preoperative communication and postoperative management.
Renal Function Improvement Correlates with 3D Echocardiographic Findings: Effect of Surgical Mitral Valve Repair
Authors: Wang Chenchen , Yang Wenbo , Shi Zhongwei , Fang Yuehua
Published: November 2021

Purpose
The relationship between surgical treatment of mitral regurgitation (MR) and renal function is not well described. We sought to evaluate renal function before and after surgical mitral valve repair (SMVR) in degenerative significant MR.
Methods
Patients with primary severe ( 4+) MR and preserved left ventricular ejection fraction (LVEF) who underwent surgical mitral valve repair, evaluated by a cutting-edge 3-dimensional (3D) echocardiographic probe were included in this study. Three CKD-EPI equations were used to calculate estimated glomerular filtration rate (eGFR) before surgery and before patients discharge. Forty patients with baseline lower mean eGFR were studied.
Results
Measurements substantiated statistically remarkable improvements in eGFR (P<0.001), multivariable linear regression modeling demonstrated a strong association between increase of eGFR and reduction of MR (P=0.003), reduction of pulmonary arterial systolic pressure (PASP, P=0.018), as well as increase of forward stroke volume(FSV, P=0.02), regardless of the reduction of LVEF, left ventricular global longitudinal strain (GLS) and left atrial ejection fraction (LAEF).
Conclusion
Renal function improves after surgical mitral valve repair in patients with degenerative severe mitral regurgitation and preserved LVEF, despite of cardiac functional worsening.
Efficient Pressure Sensors Placement for Water Distribution Network Using Flow-Tracking Analysis
Authors: Huang Y.C. , Yang W.L.
Published: November 2021

This letter presents a novel approach for efficient deployment of top pressure sensors in water distribution network. Flow-Tracking analysis using head loss coverage ratio explores a least number of top sensors in network topologies. The following sequence of top sensor plans can be effortlessly determined by simple greedy algorithm. A regular hydraulic model with 33 sensor nodes is to validate the fast and effective feature of flow-tracking method. A top set of 5 sensor nodes selected by head loss coverage ratio Hcr in flow-tracking analysis agree exactly with top set of 5 sensitive nodes selected by objective function f(Xk) by means of Sensitivity Analysis. A linear relationship between objective function f(Xk) and heads loss coverage ratio Hcr of top sensor nodes reveals high accuracy mapping from flow-tracking method to Sensitivity Analysis. Time complexity of searching top sensors node set by flow-tracking analysis is O(m⋅n). Average pressure error can be expected as low as 0.08 m with top-two sensors in sensors layout. As top sensors in deployment plan are all used, minimum error of 0.04 m is achieved. Flow-Tracking analysis has the advantages of little time complexity and accurate top sensors strategy as a new efficient solution for pressure sensors deployment in associated flow network.
Plasma RIPK3 And HMGB1 Predict Severe COVID-19 Progression In ICU Patients: A Single-Center Cohort Study
Authors: Ruskowski Katharina , Neb Holger , Talbot Steven R , Choorapoikayil Suma , Adam Elisabeth H , von Knethen Andreas , Zacharowski Kai , Heinicke Ulrike
Published: November 2021

Background: Severe progression of coronavirus disease 2019 (COVID‑19) causes respiratory failure and critical illness. Recently, these pathologies have been associated with necroptosis, a receptor‑interacting serine/threonine‑protein kinase 3 (RIPK3) dependent regulated form of inflammatory cell death. Investigations of indicator necroptosis proteins like RIPK3, mixed lineage kinase domain‑like pseudokinase (MLKL), receptor‑interacting serine/threonine‑protein kinases 1 (RIPK1), and high‑mobility group box 1 (HMGB1) in clinical COVID‑19 manifestations are lacking.Methods: A prospective prolonged cohort study including 46 intensive care unit (ICU) patients classified with moderate and severe COVID‑19 was conducted with daily measured plasma levels of indicator necroptosis proteins like RIPK3, MLKL, RIPK1, and HMGB1 by enzyme‑linked immunosorbent assay (ELISA). On this basis, a multiple logistic (regression) classification for the prediction of severe COVID‑19 progression was performed. Results: We found significantly elevated RIPK3, MLKL, HMGB1, and RIPK1 levels in COVID‑19 patients admitted to the ICU compared to healthy controls throughout the ongoing disease, indicating necroptotic processes. Above all, with combined measurements of RIPK3 and HMGB1 plasma levels, we were able to time‑independently predict COVID‑19 severity with 84% accuracy, 90% sensitivity, and 76% specificity.Conclusion: We suggest that HMGB1 and RIPK3 are potential biomarkers to identify high‑risk COVID‑19 patients and developed a classifier for COVID‑19 severity.
Effectiveness of Crisis Resolution Home Treatment for the Management of Acute Psychiatric Crises in Southern Switzerland: A Natural Experiment Based on Geography
Authors: Soldini Emiliano , Alippi Maddalena , Zufferey Maria Caiata , Lisi Angela , Lucchini Mario , Albanese Emiliano , Colombo Raffaella Ada , Rossa Simona , Bolla Emilio Carlo , Mellacqua Zefiro Benedetto , Larghi Giuseppina , Cordasco Severino , Kawohl Wolfram , Crivelli Luca , Traber Rafael
Published: November 2021

Background

Crisis Resolution Home Treatment (CRHT) is an alternative to inpatient treatment for acute psychiatric crises management. However, evidence on CRHT effectiveness is still limited. In the Canton of Ticino (Southern Switzerland), in 2016 the regional public psychiatric hospital replaced one acute ward with a CRHT. The current study was designed within this evaluation setting to assess the effectiveness of CRHT compared to standard inpatient treatment.
Methods

CRHT was offered to patients aged 18 to 65 with an acute psychiatric crisis that would have required hospitalization. Exclusion criteria were acute drug/alcohol intoxications, extreme agitation/aggressive behaviour, risk of suicide/self-harm, compulsory hospitalization, being an inmate and, due to practical reasons, living in the southern area of Ticino. We used a natural experiment based on geography, where intervention and control groups were formed according to the place of residence. Primary endpoints were reduction of psychiatric symptoms at discharge, treatment duration in days, and rate and length of readmissions during a two-year follow-up period after discharge. Safety during the treatment period was measured with the number of serious adverse events (suicide/suicide attempts, major self-harm episodes, acute alcohol/drug intoxications, aggressions to caregivers or family members). We used linear, log-linear, logistic and difference-in-differences regression models with propensity scores for the main analysis.
Results

We enrolled 321 patients; 67 were excluded because the treatment period was too short and 17 because they were transferred before the end of the treatment. 237 patients were available for data analysis, 93 in the intervention group and 144 in the control group. No serious adverse event was observed during the treatment period in both groups. Reduction of psychiatric symptoms at discharge (p-value=0.359), readmission rates (p-value=0.563) and length of readmissions (p-value=0.770) during the two-year follow-up period did not differ significantly between the two groups. Treatment duration was significantly higher in the treatment group (+29.6% on average, p-value=0.002)
Conclusions

The effectiveness of CRHT for the management of acute psychiatric crises was comparable to standard hospitalization. Further research is needed to identify relevant implementation elements, processes, and procedures, and the system level integration and scalability of CRHT in mental health services.
Trial registration

ISRCTN38472626 (17/11/2020, retrospectively registered)
Effect of Surgical Resection on Jugular Foramen Tumors: A Retrospective Study
Authors: Weijie Su , Xixi Li , Honglin Wu , Hongxing Tang , Zhong Deng , Lixuan Yang , Nu Zhang , Zhengsong Huang
Published: November 2021

The complex anatomical structure of jugular foramen (JF) makes a challenge for the diagnose and treatment of this region’s tumors. The purpose of the study was to investigate the effect of surgical resection in patients with JF tumors. A total of 77 patients with JF tumors treated with surgical resection between 2012 and 2021 were retrospectively reviewed. General characteristics, tumor classification, surgical approach and outcomes were retrospectively analyzed. The mean follow-up period was 4.5 years (ranging 0.5-8.5 years). Of the enrolled patients, 63 patients (81.82%) were diagnosed with JF schwannomas. 67 cases (87.01%) of the total patients received gross-total resection. Preoperatively, hoarseness and/or dysarthria served as the most complained symptoms (n=41, 53.25%), followed by swallowing disturbance (n = 37, 48.05%), hearing disturbance and/or tinnitus (n = 32, 41.56%). Postoperatively, a total of 52 patients (67.53%) were without significant symptoms. Worsened hoarseness and/or dysarthria symptoms were found in 14 patients (18.18%). Besides, 6 cases (7.79%) of the enrolled patients showed worsened swallowing disturbance. 8 patients (10.39%) presented with facial palsy after operation and 3 of them got improvement during the follow-up. Nine patients (12.68%) had tumor recurrence and there was one death (1.3%) associated with surgery during the perioperative period in the cohort. Therefore, surgical resection was an effective treatment of JF tumors with improvements of symptoms and good control of tumor. However, operation on this region was at the risks of worsening cranial nerve deficits and death, which needed advance in skull base surgery and rich experience.
Comparative And Phylogenetic Analyses of Six Kenya Polystachya (Orchidaceae) Species Based On The Complete Chloroplast Genome Sequences
Authors: Jiang Hui , Tian Jing , Yang Jiaxin , Dong Xiang , Zhong Zhixiang , Zhang Caifei , Hu Guangwan , Wang Qingfeng , Mwachala Geoffrey
Published: November 2021

Background: Polystachya Hook. is a large pantropical orchid genus (c. 240 species) distributed in Africa, southern Asia and the Americas, with the centre of diversity in Africa. Chloroplast (cp) genomes of plants are highly conserved and can provide much more informative DNA sites and generate much better resolution for plant phylogenies. However, for Polystachya, the whole cp genome including its structure features are yet unknown and its phylogenetic placement of the genus within the Orchidaceae is still unclear.Results: In this study, the complete cp genomes of six Polystachya species were assembled based on genome skimming. We subjected them to comparative genomic analyses and reconstructed their phylogenetic relationships. The results exhibited that the cp genomes had a typical quadripartite structure with conserved genome arrangement and moderate divergence. The cp genomes of the six Polystachya species ranged from 145,484 bp to 149,274 bp in length and had almost similar GC content of 36.9%-37.0%. Gene annotation revealed 113 unique genes. In additions, 19 genes are duplicated in the inverted regions, and 17 gene possessed intron. Comparative analysis of the overall sequence identity among six complete cp genomes confirmed that for both coding and non-coding regions in Polystachya, SC regions exhibit higher sequence variation than IRs. Furthermore, there were various amplifications in the IR region among the six Polystachya species. Most of the protein-coding genes of these species had a high degree of codon preference. We screened out specific SSR and found seven relatively highly variable loci. Moreover, 13 genes were discovered with significant positive selection. Phylogenetic analysis suggested that the six Polystachya species formed a monophyletic clade and had more closely related to tribe Vandeae. Phylogenetic relationships of the family Orchidaceae inferred from the 85 cp genome sequences were generally consistent with previous studies and robust. Conclusions: Our study reported the complete cp genomes of the six Polystachya species, and provided detailed structural analysis and comparative analysis results, which can contribute to the development of DNA markers for use in the study of genetic variability and evolutionary studies in Polystachya. In addition, the present results further demonstrate the phylogenetic position of Polystachya.
Insulin-Like Growth Factor 2 (IGF2) and Autophagy Gene Expression Alteration in Parkinson’s Disease: Potential Predictor Markers.
Authors: Sepulveda Denisse , Vidal Alvaro , Grünenwald Felipe , Troncoso-Escudero Paulina , Cisternas-Olmedo Marisol , Villagra Roque , Vergara Pedro , Aguilera Carlos , Nassif Melissa , Vidal Rene L.
Published: November 2021

Insulin-like growth factor 2 (IGF2) and autophagy-related genes have been proposed as interesting biomolecules related to idiopathic Parkinson’s disease (PD). The objective of this study was to determine the IGF2 and IGF1 levels in plasma and peripheral blood mononuclear cells (PBMCs) from patients with moderately advanced PD and explore the potential correlation with autophagy-related genes in the same blood samples. IGF1 and IGF2 levels in patients' plasma were measured by ELISA, and the IGF2 expression levels were determined by real-time PCR and Western blot in PBMCs. The expression of autophagy-related genes was evaluated by real-time PCR. The results show a significant decrease in IGF2 plasma levels in PD patients compared with a healthy control group. We also report a dramatic decrease in IGF2 mRNA and protein levels in PBMCs from PD patients. In addition, we observed a downregulation of key components of the initial stages of the autophagy process. Although IGF2 levels were not directly correlated with disease severity, we found a correlation between its levels and autophagy genes expression from the same samples, in a sex-dependent manner. To further explore this correlation, we treated mice macrophages cell culture with α-synuclein and IGF2. While α-synuclein treatment decreased levels of Beclin1 and Atg5, IGF2 treatment reverted these effects. Our results suggest a relationship between IGF2 levels and the autophagy process in PD and its potential application as a multi-biomarkers to determine the PD patients' stages of the disease.
Association of Plasma Thrombin-Antithrombin Complex and Ischemic Stroke: A Systematic Review and Meta-analysis
Authors: Song Peipei , Xie Jianqin , Li Wei , Zhang Xinying , Sun Zhipeng , You Chongge
Published: November 2021

Background and objectiveThrombin-antithrombin complex (TAT) is a prethrombotic marker, and its application in ischemic stroke is still uncertain. The purpose of this systematic review and meta-analysis is to evaluate the relationship between plasma TAT and ischemic stroke base on the current evidence.MethodsA systematic literature search was conducted for searching the relative studies that investigated the association of TAT and ischemic stroke in PubMed, EMBASE, and Cochrane library databases. Mean difference and 95% confidence interval as the effect sizes were synthesized by random effects model in Review Manager (RevMan) Version 5.4. Then, the heterogeneity was investigated using the Chi-square test and the possible sources of heterogeneity were explored by sensitivity analysis. The publication bias was estimated through Begg’s and Egger’s tests.ResultsA total of 12 eligible studies were included involving 1431 stroke cases and 532 healthy controls, of which six studies were eventually included in the meta-analysis. Plasma TAT in patients with ischemic stroke was significantly higher than that in healthy controls (MD 5.31, 95% CI =4.12-6.51, P<0.0001, I2=97.8 %). There is a difference of TAT level in the same period among cardioembolic, lacunar and atherothrombotic stroke (all P<0.0001), in which the cardioembolic stroke with the highest level. Meanwhile, it is significant of TAT levels among various phases of cardioembolic stroke and the acute phase are markedly elevated (MD 7.75, 95CI%, 6.07-9.43, P<0.001). However, no difference was found in the atherothrombotic (P=0.13) and lacunar stroke (P=0.34). Besides, the higher TAT level is closely related to the poor prognosis of patients with ischemic stroke, including higher recurrence, mortality, unfavorable recovery (modified Rankin scale >2), and poor revascularization.ConclusionsThis study suggested that plasma TAT levels are different in ischemic stroke subtypes, which are closely associated with the progression and might have an effect on the prognosis. PROSPERO CRD: 42021248787
Research On Roundness Error Consistency Model For Crank Journal Cylindrical grinding
Authors: Zeng Xu , Wanli Xiong , Ye Hongyan , Tang Zhiyong
Published: November 2021

Cylindrical grinding is an important way to form the external shape error of the crank journal, and the accuracy consistency directly affects the interchangeability of products. To study the accuracy consistency of crank journal，a dynamic model of the grinding wheel-crankshaft grinding system based on Timoshenko beam is established, and the grinding transition process simulation algorithm with iterative convergence of grinding force-transient grinding amount cycle adapted to the model is proposed, which realizes the simulation of the roundness of the crank journal coupled with the process parameters of the grinding system. Aiming at the grinding position of each crank journal, the grinding roundness of five crank journals is simulated respectively. On this basis, the crank journal roundness consistency prediction model is established, and the effectiveness of the prediction model is verified by field experiments. Finally, the influence of grinding parameters on the consistency of the roundness of crank journal is studied. The research conclusion can provide a reference for the grinding accuracy consistency design of this type of crank journal.
Atypical Presentation and Delayed Diagnosis of Gyrate Atrophy: Case Reports of Two Siblings
Authors: Ceran Tugce Horozoglu , Gediz Berrak Sekeryapan , Sonmez Kenan
Published: November 2021

Gyrate atrophy is a hereditary condition characterized by ornithine amino transferase deficiency related large areas of retinal pigment epithelium and choriocapillaris lobular shaped atrophy in the peripherial retina. In this report, we present a case of atypical presentation of gyrate atrophy. The aim of this report is to present two siblings, one of which was associated with lamellar macular hole and with a history of previous diagnosis of retinitis pigmentosa. The delayed diagnosis of gyrate atrophy was made only after her brother, who was 5 years younger than her was diagnosed with gyrate atrophy. In addition, in this report, we evaluated gyrate atrophy in terms of multimodal imaging findings, differential diagnosis and treatment of macular complications.
Ultra-short Echo Time MR Imaging in Assessing Cartilage Endplate Damage And Association Between Its Lesion and Disc Degeneration For Chronic Low Back Pain Patients
Authors: Ji Zhilin , Dou Weiqiang , Zhu Yaru , Shi Yin , Zou Yuefen
Published: November 2021

Objective: To investigate the feasibility of ultra-short echo time (UTE) MRI in assessing cartilage endplate (CEP) damage and evaluating the relationship between total endplate score (TEPS) and lumbar intervertebral disc (IVD) degeneration.Materials and methods: 35 patients were measured for IVD using UTE imaging at 3T MR. Subtracted UTE images between short and long TEs were obtained to depict anatomy of CEP. The SNR and CNR were calculated to assess the image quality. A new grading criterion for endplate evaluation was developed based on Rajasekarank.S grading in this study. Two radiologists were employed to evaluate CEP and bony vertebral endplates (VEP) using new grading criterion and assess TEPS, independently. Cohen's kappa analysis was applied to evaluate the inter-observer agreement of endplate damage assessment between two radiologists, and the Kendall's TAU-B analysis was employed to determine the relationship between TEPS and IVD degeneration evaluated with Pfirrmann grading.Results: Well structural CEP was depicted on subtracted UTE images and confirmed by high SNR (33.0±2.92) and CNR values (9.4±2.08). Qualified subtracted UTE images were used by two radiologists to evaluate CEP and VEP damage. Excellent inter-observer agreement was confirmed by high value in Cohen's kappa test (0.839,P<0.001). Ensured by this, 138 endplates from 69 IVDs of 35 patients were classified into six grades based on the new grading criterion and TEPS of each endplate was calculated. In addition, the degeneration degree of IVDs were classified into five grades. Finally, using Kendall's TAU-B analysis, significant relationship was obtained between endplate damage related TEPS and IVD degeneration (r= 0.864,P<0.001).Conclusion: Ensured by high image quality, UTE imaging might be considered an effective tool to assess CEP damage. Additionally, further calculated TEPS has shown strong positive association with IVD degeneration, suggesting that the severity of endplate damage is highly linked with the degree of IVD degeneration.
Urine Cellular DNA Point Mutation and Methylation as Potential Biomarkers for the Detection of Urothelial Carcinoma
Authors: Zhang Junjie , Xu Ran , Lu Qiang , Xu Zhenzhou , Liu Jianye , li Pei , Zhang Yaqun , luo Lufeng , zhou Chuanchi , Tang Wei , wang Zhenting , Cao Manman , Xu Genming , Wang Long
Published: November 2021

BackgroundPreviously, our team identified a seven-gene mutation panel in urine sediment to discriminate UBC from benign urological diseases. In the present study, we aimed to validate the panel in an expanded and close to natural population cohort of hematuria. Also, we tried to optimize the panel by incorporating methylation biomarkers. We performed external validation to investigate the robustness and stability of the novel panel.MethodsPatients with urothelial carcinomas and controls were prospectively recruited in clinical trial ChiCTR2000029980. The mutation panel was validated in the expanded cohort(n=333) from Hunan multicenter. Several UBC-specific methylation biomarkers were identified by comprehensive analyses of a series of TCGA, GEO and an independent cohorts, and examined in the expanded cohort. Random Forest algorithm was used to construct an optimal panel. External validation of the optimal panel was carried out in Beijing single center cohort(n=89). NGS technique was used to analyze the DNA point mutations and MS-PCR for methylation.ResultsThe AUC, sensitivity and specificity of the mutation panel in expanded cohort were 0.81, 0.67 and 0.90, respectively. After screening, only cg16966315, cg17945976 and cg24720571 were left for further analysis. The optimal panel consisted of cg24720571 and 8 point mutations, including TERT.chr5_1295228 G_A (TERT 228), FGFR3.chr4_1803568 C_G (FGFR3 568), TERT.chr5_1295250 G_A (TERT 250), FGFR3.chr4_1806099 A_G (FGFR3 099), PIK3CA.chr3_178936091 G_A (PIK3CA 091), PIK3CA.chr3_178952085 A_G (PIK3CA 085), PIK3CA.chr3_178936082 G_A (PIK3CA 082), HRAS.chr11_533874 T_C (HRAS 874). The AUC, sensitivity and specificity of the optimal panel in training group were 0.89, 0.84 and 0.79, respectively, and in test group were 0.95, 0.91 and 0.95, respectively. In the external validation, the AUC, sensitivity and specificity were 0.98, 0.93 and 0.93, respectively.ConclusionsThe optimal panel was obviously superior to previous mutation panel and showed a highly specific and robust performance. The optimal panel may be used as a replaceable approach for early detection of UC.Trial registrationThis research was registered in Chinese Clinical Trial Registry(ChiCTR2000029980).
Bullying, Present Romantic Relationship and Depression as Predictive Factors of Non-Suicidal Self-Injury in Adolescent Psychiatric Patients
Authors: Zhang Ji-Jie , Liu Yin-Du , Zhang Hua , Huang Zhuo-Hui , Wang Fei , Yang Jing-JIng , Wang Shi-Bin , Jia Fu-Jun , Hou Cai-Lan
Published: November 2021

Background: Non-suicidal self-injury (NSSI), as a major public health issue of high complexity, multifactorial causes and great socioeconomic and family impact, affects China now especially after COVID-19. The aim of this study was to explore the clinical and psychological characteristic in adolescent psychiatric patients with or without NSSI.Methods: Adolescent psychiatric patients were recruited from psychiatric outpatient and inpatient unit in Guangdong mental Health Center between October and December 2020. NSSI was evaluated by the modified version of Adolescents Self-Harm Scale. Childhood trauma was assessed by the Childhood Trauma Questionnaire-Short Form (CTQ-SF). Peer bullying experience was evaluated by The Revised Olweus Bully/Victim Questionnaire（BVQ-R). Depression was assessed by the Montgomery–Asberg Depression Rating Scale (MADRS). Clinical data were collected from electronic medical record system.Results: The sample included 157 adolescent psychiatric patients (72.6% female), aged 13-18 years (M=15.39, SD=0.145). NSSI group experienced more peer bullying (t=4.08,P＜0.001), more likely to get into romantic relationship currently(χ2=5.38, P=0.02), more times of hospitalization (t=0.36, P<0.001), receiving more antipsychotic treatment (t=3.58, P<0.001), benzodiazepine treatment (t=3.46, P＜0.001), and mood-stabilizer treatment (χ2 =8.53, P<0.001). The significant predictor of NSSI for the last one year included being in romantic relationship currently (OR =4.27, 95% CI=[1.53,11.93]), outpatient (OR=0.38, 95%CI=[0.16,0.88]), BVQ-R total (OR=1.10, 95% CI=[1.02,1.18])，MARDS total (OR= 1.05, 95% CI=[1.01,1.09]), and benzodiazepine PDD/DDD (OR=5.79, 95% CI=[0.99,33.72]).Conclusions: Adolescent psychiatric patients with NSSI have significantly higher incidences of life event such as peer bulling, childhood trauma experience, and they were more likely to get into a romantic relationship. Meanwhile, patients with NSSI had significantly severe level of depression, being more on benzodiazepine and mood-stabilizer use. This provides a valuable basis for our clinical treatment of adolescent mental patients with NSSI.
Dietary Diversity Practice and its Influencing Factors Among Pregnant Women in Afar Region of Ethiopia: A Cross-sectional Study Design Supplemented by Qualitative Study.
Authors: Wondmeneh Temesgen Gebeyehu
Published: November 2021

Background: Women in low-income countries are frequently malnourished when they become pregnant, and the demands of pregnancy can exacerbate nutritional deficiencies, particularly micronutrient deficiencies, with serious health effects on the fetus. Antenatal nutritional supplements can help to improve birth outcomes and maternal health. As a result, determining the magnitude of dietary diversity and its influencing factors among pregnant women in the pastoral region of Afar, where no study has been conducted, is an essential in order to establish an intervention program in the region. Method: A mixed study comprising 241 pregnant women and six focus group discussions was conducted from October 1 to November 10, 2018. Participants in the quantitative study were selected by a systematic sampling method, whereas those in the focus group discussions were chosen by using purposive sampling method. The data was collected using pretested questionnaires administered via face-to-face interviews. The relationship between dietary diversity practice and its affecting factors was investigated using logistic regression analysis. The strength of the association was determined by odds ratio with a 95 % confidence interval. Thematic framework was used to analyse the qualitative data.Results: Seventy-three percent of pregnant women had poor dietary diversity. Dietary diversity was higher in younger pregnant women who were under the age of 20 years (AOR=5.8; at 95% CI: 1.6-13.5) and aged between 21-25 years (AOR=3.9; at 95 percent CI:1.1-12.2) than in older pregnant women with over the age of 30 years. Those participants with a high average family income (above 4500 birr) had a good dietary diversity when compared to those with family income less than 1500 birr (AOR=0.1:95% 39 CI;0.02-0.7) and between 1500-3000 birr (AOR=0.05:95% CI;0.01-0.2). Pregnant women who had one antenatal care visit practiced less dietary diversity than those who had four or more (AOR=0.18: 95 percent CI; 0.04-0.8). Protein-rich foods (meat and eggs), semisolid foods (porridge and cereal soup), milk, fruit (banana) and vegetable (cabbage) 43 were the most commonly avoided foods by pregnant women. These meals were commonly avoided since they produced large babies and were attached to the fetus's body.Conclusion: The majority of study participants had a poor dietary diversity. Pregnant women with a low family income and only one prenatal care visit were less likely than those with a high family income and four or more antenatal care visits to practice dietary diversity, respectively. Most pregnant women avoided high-protein diets, semi-solid foods, milk, vegetable and fruit. Due to the presumptions of producing large fetus and attached to the fetus's body, these foods were avoided.
Chlorine poisoning caused by improper mixing of household disinfectants during the COVID-19 pandemic
Authors: Guodong Lin , Jieyi Wu , Xiaobo Peng , xiaoxia Lu , zhongying Liu , Zhiguo Pan , zewu Qiu , Jianguang Dong
Published: November 2021

Background

During the coronavirus disease 2019 (COVID-19) pandemic, many people have abused and misused disinfectants, leading to many poisoning incidents. However, there are few clinical case reports of poisoning caused by mixed household disinfectants. This study summarized the clinical characteristics and treatment effects of chlorine poisoning caused by improper mixing of hypochlorite bleach with acidic cleaning agents to improve the understanding of the disease.
Methods

We retrospectively analyzed the basic data, clinical symptoms, treatment methods, imaging, and other clinical data of seven patients with chlorine poisoning, caused by an improper mixture of hypochlorite bleach and acidic cleaning agents, who were admitted to the National Army Poisoning Treatment Center.
Results

The seven patients (three men and four women) had an average age of 48.8 years (18–67 years). The average poisoning time (time from exposure to poison to treatment) was 57 h (4–240 h). All seven patients were involved in cleaning bathrooms during the COVID-19 pandemic. Chest computed tomography scans showed bilateral lung effusions or inflammatory changes in five patients and no obvious exudation or inflammatory changes in two. The partial pressure of oxygen decreased in six patients, and respiratory failure occurred in one. Five patients had different degrees of increase in white blood cell count. For treatment, humidified oxygen therapy, non-invasive mechanical ventilation, intravenous corticosteroids, inhaled hormone, bronchial spasmolytics, antibiotics, and other symptomatic and supportive treatments were provided. The average length of hospital stay was 7 days (4–9 days). All seven patients recovered and were discharged.
Conclusions

Improper mixing of house disinfectants during the COVID-19 pandemic may cause damage to the respiratory system due to chlorine poisoning. Corticosteroids may improve lung exudation in severe cases. Additionally, symptomatic supportive treatment should be performed early.
Identification and Genetic Diversity Analysis of Rickettsia in Dermacentor Nuttalli Within Inner Mongolia, China
Authors: Gui Zheng , Cai Hao , Qi Dong-Dong , Zhang Shun , Fu Shao-Yin , Mao Rui , Yu Jing-Feng , Si Xiao-Yan , Cai Ting
Published: November 2021

Background

The pathogen genus Rickettsia contains the linages spotted fever group, typhus group, transitional group, and the ancestral group, of which the spotted fever group Rickettsia (SFGR) is transmitted by ticks. Dermacentor nuttalli is considered the main vector carrying SFGR. Studying the genetic diversity and population structure of Rickettsia is essential for developing effective control strategies and predicting evolutionary trends of the pathogens.
Methods

We collected 408 Dermacentor nuttalli in the Inner Mongolia Autonomous region in 2019, detected Rickettsia infection, and characterized the haplotypes. The extracted Rickettsia DNA of the gltA and ompA genes were amplified and sequenced.
Result

In this study, 10 haplotypes of the gltA gene and 22 haplotypes of the ompA gene were obtained. In the two resulting phylogenetic trees, the haplotypes G1-G7 and G9 of the gltA gene clustered with Rickettsia raoultii, while G8 and G10 clustered with Rickettsia sibirica. Haplotypes O1-O15, O18 and O20-O22 of the ompA gene clustered with Rickettsia raoultii, while O16 and O19 clustered with Rickettsia sibirica. The average haplotype diversity was 0.3 for gltA and 0.7 for ompA, while the average nucleotide diversity was greater than 0.05. Neutrality tests were insignificant for Tajima’s D results and Fu’s Fs results. The fixation index values (FST) showed that the degree of genetic differentiation between most sampled populations was small (FST<0.05), while others were medium (FST>0.05) and large (FST>0.15). Analysis of molecular variance (AMOVA) revealed that the variation within populations was greater than that between populations. The mismatch analysis of Rickettsia showed double peaks.
Conclusion

We found two genotypes of Rickettsia: Rickettsia raoultii and Rickettsia sibirica. The high genetic diversity of Rickettsia allows for easy adaption to different environments; furthermore, genetic differentiation between populations is small and Rickettsia populations do not show a pedigree geographical structure. The high rates of retention and infestation of Rickettsia in Dermacentor nuttalli together with the animal husbandry exchange in China gradually lead to the genetic characteristics of Rickettsia harmonizing across various regions. Overall, the significant genetic diversity and geographic structure of Rickettsia in Dermacentor nuttalli are critical for SFGR control.
Efficacy of single-dose HPV vaccination among young African women
Authors: Barnabas Ruanne V. , Brown Elizabeth R. , Onono Maricianah A. , Bukusi Elizabeth A. , Njoroge Betty , Winer Rachel L. , Galloway Denise A. , Pinder Leeya F. , Donnell Deborah , Wakhungu Imelda , Congo Ouma , Biwott Charlene , Kimanthi Syovata , Oluoch Lynda , Heller Kate B. , Leingang Hannah , Morrison Susan , Rechkina Elena , Cherne Stephen , Schaafsma Torin T. , McClelland R. Scott , Celum Connie , Baeten Jared M. , Mugo Nelly , Team for the KEN SHE Study
Published: November 2021

Background: Single-dose HPV vaccination, if efficacious, would be tremendously advantageous; simplifying implementation and decreasing costs.Methods: We performed a randomized, multi-center, double-blind, controlled trial of single-dose nonavalent (HPV 16/18/31/33/45/52/58/6/11) or bivalent (HPV 16/18) HPV vaccination compared to meningococcal vaccination among Kenyan women aged 15-20 years. Enrollment and six monthly cervical swabs and a month three vaginal swab were tested for HPV DNA. Enrollment sera were tested for HPV antibodies. The modified intent-to-treat (mITT) cohort comprised participants who tested HPV antibody negative at enrollment and HPV DNA negative at enrollment and month three. The primary outcome was incident persistent vaccine-type HPV infection by month 18.Results: Between December 2018 and June 2021, 2,275 women were randomly assigned and followed; 758 received the nonavalent HPV vaccine, 760 the bivalent HPV vaccine, and 757 the meningococcal vaccine; retention was 98%. Thirty eight incident persistent infections were detected in the HPV 16/18 mITT cohort: one each among participants assigned to the bivalent and nonavalent groups and 36 among those assigned to the meningococcal group; nonavalent Vaccine Efficacy (VE) was 97.5% (95%CI 81.7-99.7%, p=<0.0001), and bivalent VE was 97.5% (95%CI 81.6-99.7%, p=<0.0001). Thirty-three incident persistent infections were detected in the HPV 16/18/31/33/45/52/58 mITT cohort: four in the nonavalent group and 29 in the meningococcal group; nonavalent VE for HPV 16/18/31/33/45/52/58 was 88.9% (95%CI 68.5-96.1%, p<0.0001). The rate of SAEs was 4.5-5.2% by group.Conclusions: Single-dose bivalent and nonavalent HPV vaccines were each highly effective in preventing incident persistent oncogenic HPV infection, similar to multidose regimens.
AstraZeneca COVID-19 vaccine: A possible risk factor for Stroke, Case Series from Sudan
Authors: Siddig Amira , Hussien Abbasher , Ahmed Khabab Abbasher Hussien Mohamed , Haroun Mazin S. Hassan , Ali Mustafa Mohamed Ibrahim , Malekaldar Mohamed , Abbasher AlHussien , Abbasher Mohammed , Abbasher Abubaker Alsedig , Eljack Mohammed Mahmmoud Fadel Allah
Published: November 2021

Cerebrovascular accident (CVA) is one of the commonest neurological deficits. There is a well-known association between COVID-19 and stroke. We present a case series of Sudanese patients who developed CVA after receiving the AstraZeneca COVID-19 vaccine suggesting a relationship between the vaccine and CVA.
Anterior Dislocation After Total Hip Arthroplasty: A Rare Complication
Authors: Keny Swapnil Anil , Mohanty Shubhranshu , Rathod Tushar , Kamble Prashant , Kothari Ronak
Published: November 2021

Anterior dislocation after total hip arthroplasty (THA) is a rare event and its treatment protocol is controversial. The most important factor responsible for this complication is malposition of the components. We present a rare case of early anterior dislocation after THA in a 72-year female due to excessive anteverted position of the acetabulum socket as confirmed by radiological evaluation. Closed reduction was not successful. Revision surgery with correction of acetabulum cup version and inclination within the ‘safe zone’ resulted in excellent stability of prosthesis intra-op which even precluded the use of advanced implant designs such as constrained liners. At one-year follow-up, the patient is mobilized with a walking stick and has no recurrence of dislocation. This highlights the role of proper implant positioning which can reduce the complexity of the surgical procedure and provide good functional outcome in such catastrophic events.
Evaluation of Autofluorescence in Identifying Parathyroid Glands by Measuring Parathyroid Hormone in Fine-Needle Biopsy Washings
Authors: liu Zhen , Ma Run-sheng , Jia Jun-li , Wang Tao , Zuo Dao-hong , Yin De-tao
Published: November 2021

Background: Near-infrared autofluorescence imaging has potentially great value for assisting endocrine surgeons in identifying parathyroid glands and may dramatically change the surgical strategy of endocrine surgeons in thyroid surgery. This study is designed to objectively evaluate the role of near-infrared autofluorescence imaging in identifying parathyroid glands during thyroid surgery by measuring intraoperative parathyroid hormone in fine-needle aspiration biopsy washings.Methods: A case series study was conducted at a tertiary referral teaching hospital in China from September 2019 to April 2020. Patients undergoing total thyroidectomy with or without neck lymph node dissection were consecutively included. The surgeon used near-infrared autofluorescence imaging to identify parathyroid glands during thyroid surgery and confirmed suspicious parathyroid tissues by measuring their intraoperative parathyroid hormone. Nanocarbon was injected into the thyroid gland if the thyroid autofluorescence intensity was too strong. The sensitivity and accuracy of near-infrared autofluorescence imaging and vision for identifying parathyroid glands, and the difference in autofluorescence intensity in various tissues were the main outcomes.RESULTS: Overall, 238 patients completed the trial. Based on the pathological and aIOPTH results, the sensitivity of near-infrared autofluorescence imaging for detecting parathyroid glands（568 of 596 parathyroid glands; 95.30%）was significantly higher than that of vision（517 of 596 parathyroid glands; 86.74%, P<.001). The accuracy of near-infrared autofluorescence imaging (764 of 841 tissues; 90.84%) was significantly higher than that of vision (567 of 841 tissues; 67.42%, P<.001) when the evaluations of certain tissues were inconsistent. There was a significant difference between the autofluorescence intensity of the parathyroid glands and that of the lymph nodes (74.19 ± 17.82 vs 33.97 ± 10.64, P<.001).CONCLUSIONS: The use of near-infrared autofluorescence imaging, along with intraoperative parathyroid hormone and nanocarbon for the identification of parathyroid glands in thyroid surgery may increase the number of confirmed parathyroid glands. Using near-infrared autofluorescence imaging can effectively distinguish lymph nodes and parathyroid glands during lymph node dissection.
Mouthwashes with Plain Water Prevent Oral Mucositis Secondary to Hematopoietic Stem Cell Transplantation in Hematological Cancer Patients: A Retrospective Study
Authors: Du Xinwen , Zhang Chuanli , Chen Fengjiao , Leng Yamei , Zheng Yuhuan
Published: November 2021

Background Oral mucositis (OM) is a common adverse effect in hematological cancer patients who have received hematopoietic stem cell transplantation (HSCT). In this study, we compared mouthwash with nystatin, aloe vera or plain water in OM prevention.Design A retrospective chart review was conducted in participants. The incidence, severity and duration of OM, duration of oral pain, and the use of antalgesics were recorded.Setting/participants Hematological cancer patients who had received HSCT from January 2014 to December 2020 in West China Hospital were included in this study.Results A total of 150 patients were included in our retrospective analysis. The nystatin group had the highest incidence (100.0%) of OM, followed by the aloe vera group (44.8%), the plain water group had the lowest incidence of OM (20.0%), and the nystatin group had the highest severity and the longest duration of oral mucositis. The incidence, severity and duration of pain in the nystatin group were significantly higher than the aloe vera group and plain water group, and the use of analgesic drugs in the nystatin group was also significantly higher than the other two groups (P<0.05).Conclusions In our hospital setting, plain water mouthwash achieves great effect in OM prevention in hematological cancer patients who have received HSCT.
Length and Weight (LW) Related Variations on Haematological Parameters of Hetropneustes Fossilis (Bloch.)
Authors: Mishra Induja , Joshi Namita , Nath Pashupati , Joshi B. D.
Published: November 2021

The paper mainly described the haematological values of a fresh water catfish Hetropneustes fossilis (Bloch.) in relation to its length and weight which are the prime basic factor of the differences in blood parameters of any living creature including fishes. The hematological parameters showed significant differences with increase in length and weight of the fishes. Differential leucocytes count did not showed any significant differences except macrophages and differential erythrocytes count showed significant differences only in macrocytes. All three groups (Length and weight) of fishes showed significant positive correlations for total erythrocytes count, hemoglobin, mean corpuscular hemoglobin and erythrocyte sedimentation rate while negative correlation was noted for mean corpuscular hemoglobin; mean cell volume. Among differential leukocytes count only neutrophil showed positive correlation, while other parameters did not show any significant correlation. In differential erythrocyte count only microcytes showed significant positive correlation.