bluuebunny/crossref_metadata_2025 huggingface dataset:
Action Rules of Lowest Cost and Action Set Correlations
Authors: Tzacheva Angelina A. , Shankar Ramya A. , Ramachandran Sridharan , Bagavathi Arunkumar
Published: February 2020

A knowledge discovery system is prone to yielding plenty of patterns, presented in the form of rules. Sifting through to identify useful and interesting patterns is a tedious and time consuming process. An important measure of interestingness is: whether or not the pattern can be used in the decision making process of a business to increase profit. Hence, actionable patterns, such as action rules, are desirable. Action rules may suggest actions to be taken based on the discovered knowledge. In this way contributing to business strategies and scientific research.

The large amounts of knowledge in the form of rules presents a challenge of identifying the essence, the most important part, of high usability. We focus on decreasing the space of action rules through generalization. In this work, we present a new method for computing the lowest cost of action rules and their generalizations. We discover action rules of lowest cost by taking into account the correlations between individual atomic action sets.
Morphisms in Binary Rough Set Theory
Authors: Zheng Tingting
Published: February 2020

Some scholars have proposed homomorphisms between information systems based on consistent functions. However, the binary relations in the codomain induced by consistent functions thoroughly depend on the binary relations induced by the original domain systems. This paper introduces the concept of core knowledge to analyze the intrinsical topology structures of binary approximation spaces, binary knowledge bases and binary information systems. Because of the three different categories, we use the term “morphism” from category theory to depict the communication into the three categories. A morphism can be regarded as the composition of a natural projection induced by core knowledge and an embedding, which are more general than homomorphisms. What’s more, this paper proposes the notion of isomorphism and shows that the two isomorphic categories can be seen as one category based on the topological invariance. Considering that the reduction of knowledge and attributes should be based on the premise of maintaining the structure of core knowledge, isomorphisms will provide the theoretical basis of the reduction.
Higher-Order Rank Functions on Directed Graphs
Authors: Kashiwabara Kenji , Horie Ikumi , Yamaguchi Kazunori
Published: February 2020

We introduce a new higher-order rank function with the capability to completely discriminate non-equivalent nodes. We review the partition lattice and rank functions and situate the existing rank functions and higher-order rank functions within the formalization. We propose a new refining operator and a new rank function that are better than the existing ones in some applications. We also show that the entire topology (graph) can be reconstructed from only our higher-order ranks making it possible to compare nodes in different graphs and to update the equivalence of nodes when an edge is added. Finally, we briefly describe the use of our higher-order rank function in analyzing web pages as a possible application in different domains.
Flash-Aware Storage of the Column Oriented Databases
Authors: Macyna Wojciech , Kukowski Michal
Published: February 2020

Solid state disks become the very popular storage devices. Nonetheless, their architecture based on flash memory has some limitations. They suffer from poor random write performance, as the flash memory blocks must be erased before write. Nowadays, among many database models, the column-oriented databases have attracted the attention. In this model, the data from the particular columns of the database table are stored separately in the memory blocks. As a consequence, only such columns are derived from the memory which are necessary for query execution. In this way, I/O number is reduced, what drastically increases the database performance. This paper proposes a new storage method for the column oriented databases on solid state disks. In this method, the data from each column is stored as a separated structure, called Column-Flash tree (CF-tree). The table is always sorted by a particular column (or a set of columns). Due to utilizing fractional cascading and tree-like structure, the efficiency of update and search is obtained. The storage may be adjusted to the altering query pattern and disk characteristics by changing the height of the CF-tree and the capacity of its levels. In contrast to the other models, the approach may be applied to both read and write optimized databases.
Apolipoprotein E Facilitates Amyloid-β Oligomer-Induced Tau Phosphorylation
Authors: Hou Ting-ting , Han Yun-Dan , Cong Lin , Liu Cui-cui , Liang Xiao-Yan , Xue Fu-zhong , Du Yi-feng
Published: February 2020

Hyperphosphorylated tau is one of the key characteristics of Alzheimer’s disease (AD), and tau pathology correlates with cognitive impairment in AD better than amyloid-β (Aβ) pathology. Thus, a complete understanding of the relevant factors involved in tau phosphorylation is important for AD treatment. APOE ɛ 4, the strongest genetic risk factor for AD, was found to be involved in tau pathology in frontotemporal dementia. This result indicated that apolipoprotein E (ApoE) may also participate in tau phosphorylation in AD. In the present study, we injected Aβ oligomer (AβO) into the lateral ventricles of wild-type (WT) mice and apoE-/- mice to test the process of tau phosphorylation in the acute phase. We found that the phosphorylated tau and phosphokinase levels were higher in WT mice than in apoE-/- mice. These phenomena were also confirmed in vitro. ApoE ɛ4-treated apoE-/- neurons exhibited more phosphorylated tau than ApoE ɛ2- and ApoE ɛ3-treated neurons. We also found that AβO induced more serious inflammation in WT mice and in ApoE-positive cultured neurons. Anti-inflammatory treatment reduced the phosphorylated tau level induced by AβOs in ApoE-positive neurons. These results suggest that ApoE may facilitate the phosphorylation of tau induced by AβO via inflammation.
How Accurately Do Patients and Their Care Partners Report Results of Amyloid-β PET Scans for Alzheimer’s Disease Assessment?
Authors: James Hailey J. , Van Houtven Courtney Harold , Lippmann Steven , Burke James R. , Shepherd-Banigan Megan , Belanger Emmanuelle , Wetle Terrie Fox , Plassman Brenda L.
Published: February 2020

Background:

Amyloid-β PET scans will likely become an integral part of the diagnostic evaluation for Alzheimer’s disease if Medicare approves reimbursement for the scans. However, little is known about patients’ and their care partners’ interpretation of scan results.

Objective:

This study seeks to understand how accurately patients with mild cognitive impairment (MCI) or dementia and their care partners report results of amyloid-β PET scans and factors related to correct reporting.

Methods:

A mixed-methods approach was used to analyze survey data from 1,845 patient-care partner dyads and responses to open-ended questions about interpretation of scan results from a sub-sample of 200 dyads.

Results:

Eighty-three percent of patients and 85% of care partners correctly reported amyloid-β PET scan results. Patients’ higher cognitive function was associated with a small but significant decrease in the predicted probability of not only patients accurately reporting scan results (ME: –0.004, 95% CI: –0.007, –0.000), but also care partners accurately reporting scan results (ME: –0.006, 95% CI: –0.007, –0.001), as well as decreased concordance between patient and care partner reports (ME: –0.004, 95% CI: –0.007, –0.001). Content analysis of open-ended responses found that participants who reported the scan results incorrectly exhibited more confusion about diagnostic terminology than those who correctly reported the scan results.

Conclusion:

Overall, patients with MCI or dementia showed high rates of accurate reporting of amyloid-β PET scan results. However, responses to questions about the meaning of the scan results highlight the need for improved provider communication, including providing written explanations and better prognostic information.
Sleep-Wake Cycle in Alzheimer’s Disease Is Associated with Tau Pathology and Orexin Dysregulation
Authors: Liguori Claudio , Spanetta Matteo , Izzi Francesca , Franchini Flaminia , Nuccetelli Marzia , Sancesario Giulia Maria , Di Santo Simona , Bernardini Sergio , Mercuri Nicola Biagio , Placidi Fabio
Published: February 2020

Background:

Alzheimer’s disease (AD) is the most common form of dementia. It is mainly characterized by a progressive deterioration of cognition, but sleep-wake cycle disturbances frequently occur. Irregular sleep-wake cycle, insomnia, and daytime napping usually occur in patients with AD in the course of the disease.

Objective:

The aim of the present study was to verify the sleep-wake cycle in mild to moderate AD patients compared to controls, and to evaluate the relationship between the sleep-wake cycle impairment and the neuropsychological testing, CSF AD biomarkers, and CSF orexin concentrations.

Methods:

Mild to moderate AD patients were enrolled and underwent 14-day actigraphic recording, sleep diary, neuropsychological testing, and CSF biomarkers analysis. All patients were compared to controls.

Results:

Eighteen AD patients were compared to ten controls. AD patients showed the alteration of the sleep-wake cycle, featured by sleep dysregulation and daytime wake fragmentation, with respect to controls. Considering the correlation analysis, we documented the correlation between tau proteins and orexin CSF levels and sleep-wake cycle dysregulation.

Conclusion:

This study confirmed the dysregulation of sleep-wake cycle in AD patients, as reflected by the daytime wake fragmentation, irregular sleep-wake rhythm, and nocturnal sleep impairment. This sleep-wake cycle disorder correlates with AD neuropathological in vivo features and brain orexin activity. Hence, we suppose that a more marked AD pathology coupled with orexinergic system dysregulation may promote sleep-wake cycle impairment in AD patients.
Cerebellar White Matter Disruption in Alzheimer’s Disease Patients: A Diffusion Tensor Imaging Study
Authors: Toniolo Sofia , Serra Laura , Olivito Giusy , Caltagirone Carlo , Mercuri Nicola Biagio , Marra Camillo , Cercignani Mara , Bozzali Marco
Published: February 2020

The cognitive role of the cerebellum has recently gained much attention, and its pivotal role in Alzheimer’s disease (AD) has now been widely recognized. Diffusion tensor imaging (DTI) has been used to evaluate the disruption of the microstructural milieu in AD, and though several white matter (WM) tracts such as corpus callosum, inferior and superior longitudinal fasciculus, cingulum, fornix, and uncinate fasciculus have been evaluated in AD, data on cerebellar WM tracts are currently lacking. We performed a tractography-based DTI reconstruction of the middle cerebellar peduncle (MCP), and the left and right superior cerebellar peduncles separately (SCPL and SCPR) and addressed the differences in fractional anisotropy (FA), axial diffusivity (Dax), radial diffusivity (RD), and mean diffusivity (MD) in the three tracts between 50 patients with AD and 25 healthy subjects. We found that AD patients showed a lower FA and a higher RD compared to healthy subjects in MCP, SCPL, and SCPR. Moreover, higher MD was found in SCPR and SCPL and higher Dax in SCPL. This result is important as it challenges the traditional view that WM bundles in the cerebellum are unaffected in AD and might identify new targets for therapeutic interventions.
Screening for Lifetime History of Traumatic Brain Injury Among Older American and Irish Adults at Risk for Dementia: Development and Validation of a Web-Based Survey
Authors: Gardner Raquel C. , Rivera Ernesto , O’Grady Megan , Doherty Colin , Yaffe Kristine , Corrigan John D. , Bogner Jennifer , Kramer Joel , Wilson Fiona
Published: February 2020

Background:

Traumatic brain injury (TBI) is an established risk factor for dementia but mechanisms are uncertain. Accurate TBI exposure classification is critical for cognitive aging research studies seeking to discover mechanisms and treatments of post-TBI dementia. Brief TBI screens, commonly used in epidemiological studies of cognitive aging, are insensitive, leading to exposure mis-classification. Comprehensive TBI interviews, while more sensitive, may be impractical.

Objective:

We aimed to develop and validate a scalable, self-administered, comprehensive, web-based, TBI exposure survey for use in international cognitive aging research.

Methods:

We adapted a gold-standard comprehensive TBI interview (the Ohio State University TBI Identification Method; OSU TBI-ID) into a self-administered web-based survey for older adults (Older Adult modification of the OSU TBI-ID; OA OSU TBI-ID). We assessed reliability of our web-based survey versus the gold-standard interview among 97 older adults with normal cognition and mild cognitive impairment (MCI). In addition, we assessed sensitivity of the National Alzheimer’s Coordinating Center Uniform Data Set (NACC UDS) brief TBI screen versus the interview among 70 older adults with normal cognition.

Results:

Our OA OSU TBI-ID web-based survey had good to excellent reliability versus the interview ( κ 0.66–0.73; ICCs 0.68–0.81) even among the sub-set with MCI ( κ 0.74–0.88; ICCs 0.76–0.85), except for several age-at-injury variables. The NACC UDS brief TBI screen missed 50% of TBI exposures identified using the OSU TBI-ID interview.

Conclusion:

The OSU TBI-ID interview and web-based survey may facilitate more accurate TBI exposure classification in cognitive aging research thereby accelerating discovery of targetable mechanisms of post-TBI dementia.
Working Towards a Blood-Derived Gene Expression Biomarker Specific for Alzheimer’s Disease
Authors: Patel Hamel , Iniesta Raquel , Stahl Daniel , Dobson Richard J.B. , Newhouse Stephen J.
Published: February 2020

Background:

The typical approach to identify blood-derived gene expression signatures as a biomarker for Alzheimer’s disease (AD) have relied on training classification models using AD and healthy controls only. This may inadvertently result in the identification of markers for general illness rather than being disease-specific.

Objective:

Investigate whether incorporating additional related disorders in the classification model development process can lead to the discovery of an AD-specific gene expression signature.

Methods:

Two types of XGBoost classification models were developed. The first used 160 AD and 127 healthy controls and the second used the same 160 AD with 6,318 upsampled mixed controls consisting of Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, bipolar disorder, schizophrenia, coronary artery disease, rheumatoid arthritis, chronic obstructive pulmonary disease, and cognitively healthy subjects. Both classification models were evaluated in an independent cohort consisting of 127 AD and 687 mixed controls.

Results:

The AD versus healthy control models resulted in an average 48.7% sensitivity (95% CI = 34.7–64.6), 41.9% specificity (95% CI = 26.8–54.3), 13.6% PPV (95% CI = 9.9–18.5), and 81.1% NPV (95% CI = 73.3–87.7). In contrast, the mixed control models resulted in an average of 40.8% sensitivity (95% CI = 27.5–52.0), 95.3% specificity (95% CI = 93.3–97.1), 61.4% PPV (95% CI = 53.8–69.6), and 89.7% NPV (95% CI = 87.8–91.4).

Conclusions:

This early work demonstrates the value of incorporating additional related disorders into the classification model developmental process, which can result in models with improved ability to distinguish AD from a heterogeneous aging population. However, further improvement to the sensitivity of the test is still required.
Glucose Fluctuations Are Linked to Disrupted Brain Functional Architecture and Cognitive Impairment
Authors: Xia Wenqing , Luo Yong , Chen Yu-Chen , Chen Huiyou , Ma Jianhua , Yin Xindao
Published: February 2020

Background:

Type 2 diabetes mellitus (T2DM) accelerates cognitive decline, which is believed to be triggered by aberrant neural activity.

Objective:

To explore how glucose fluctuations impact brain functional architecture and cognition in T2DM patients.

Methods:

T2DM patients were divided according to glycemic variability, forming two categories: patients with fluctuating glucose levels and patients with stable glucose levels. Degree centrality (DC) was calculated within the cerebral gray matter of each participant and was compared among the two patient groups and a healthy control group. The relationships between glucose fluctuations and aberrant DC and cognitive performance, as well as the relationship between aberrant DC and cognitive performance, were further explored.

Results:

Compared with T2DM patients with stable glucose levels, T2DM patients with fluctuating glucose levels exhibited significantly worse performance on the Montreal Cognitive Assessment, Trail Making Test-B (TMT-B), and verbal fluency test (VFT), as well as significant decreases in DC in certain regions, most of which were within the default mode network. In the combined T2DM group, the mean amplitude of glycemic excursions (MAGE) was positively correlated with TMT-B scores and negatively correlated with VFT scores. Moreover, the MAGE was negatively correlated with DC in the left medial prefrontal cortex (mPFC). In addition, TMT-B scores were negatively correlated with reduced DC in the left mPFC.

Conclusion:

These findings further contribute to the mounting evidence of the effects of glycemic variability on the diabetic brain. Tightened control of glucose fluctuations might prevent cognitive decline and changes in brain functional architecture in T2DM individuals.
Myocardial Infarction Predisposes Neurodegenerative Diseases
Authors: Zhang Wei , Luo Peng
Published: February 2020

Cardiovascular disorders, e.g., atherosclerosis and hypertension, increase susceptibility to neurodegenerative diseases, like dementia and Alzheimer’s disease (AD), with undetermined mechanisms. Moreover, whether myocardial infarction (MI) may similarly increases occurrence of AD is unknown. In the current study, we performed a MI model in wild-type and AD-prone APP/PS1 mice and assessed the development of AD in these mice. We found that MI-treated mice of both wild-type and APP/PS1 behaved poorer in a social recognition test, the Morris water maze, and the plus-maze discriminative avoidance task, compared to sham-treated controls. Mechanistically, MI significantly increased the levels of reactive oxygen species, as well as increased deposition of amyloid-β peptide aggregates and phosphorylation of tau protein in mouse brain, two signature pathological features for AD. Moreover, the microglia in the MI-mice appeared to alter polarization to a more proinflammatory phenotype. Together, our data suggest that MI may be a predisposing factor for AD development.
Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer’s Disease
Authors: Cipollari Eleonora , Szapary Hannah J. , Picataggi Antonino , Billheimer Jeffrey T. , Lyssenko Catherine A. , Ying Gui-Shuang , Shaw Leslie M. , Kling Mitchel A. , Kaddurah-Daouk Rima , Rader Daniel J. , Praticò Domenico , Lyssenko Nicholas N. ,   for the Alzheimer’s Disease Metabolomics Consortium
Published: February 2020

Background:

Basic research has implicated intracellular cholesterol in neurons, microglia, and astrocytes in the pathogenesis of Alzheimer’s disease (AD), but there is presently no assay to access intracellular cholesterol in neural cells in living people in the context of AD.

Objective:

To devise and characterize an assay that can access intracellular cholesterol and cholesterol efflux in neural cells in living subjects.

Methods:

We modified the protocol for high-density lipoprotein cholesterol efflux capacity (CEC) from macrophages, a biomarker that accesses cholesterol in macrophages in atherosclerosis. To measure cerebrospinal fluid (CSF) CECs from neurons, microglia, and astrocytes, CSF was exposed to, correspondingly, neuronal, microglial, and astrocytic cholesterol source cells. Human neuroblastoma SH-SY5Y, mouse microglial N9, and human astroglial A172 cells were used as the cholesterol source cells. CSF samples were screened for contamination with blood. CSF CECs were measured in a small cohort of 22 individuals.

Results:

CSF CECs from neurons, microglia, and astrocytes were moderately to moderately strongly correlated with CSF concentrations of cholesterol, apolipoprotein A-I, apolipoprotein E, and clusterin (Pearson’s r = 0.53–0.86), were in poor agreement with one another regarding CEC of the CSF samples (Lin’s concordance coefficient r c = 0.71–0.76), and were best predicted by models consisting of, correspondingly, CSF phospholipid (R2 = 0.87, p < 0.0001), CSF apolipoprotein A-I and clusterin (R2 = 0.90, p < 0.0001), and CSF clusterin (R2 = 0.62, p = 0.0005).

Conclusion:

Characteristics of the CSF CEC metrics suggest a potential for independent association with AD and provision of fresh insight into the role of cholesterol in AD pathogenesis.
The Problem of the Church and the Nation as Two Forms of the Organization of Humanity in Arsen Richinsky's Scientific Works
Authors: Yushchyshyn O.
Published: February 2020

Acquaintance with the work of "Problems of Ukrainian Religious Consciousness" by Arsen Richinsky showed that the questions raised by the researcher at the beginning of XX century. even more actualized at the beginning of the XXI century. - in the period of Ukrainian Independent Nation's approval, when with the adoption of the Law of Ukraine "On Freedom of Conscience and Religious Organizations", in 1991 the influence of religious factor on the consciousness of Ukrainian society increased. This research, without exaggeration, is a tremendous contribution to the Ukrainian theoretical and practical religious studies. Also important is the scientific editing and streamlining of its leading contemporary scholars in the field of national-religious issues A. Kolodny, O. Sagan, and A. Goodyma, without which it would remain unknown to the reader and history as a whole, and would not be an incomplete component of the Christian factor - universal perception of the gospel doctrine through the prism of national color.
Pagan traditions in the formation of Ukrainian ethno-confessional spirituality according to A.Richinsky
Authors: Sheretyuk Ruslana M.
Published: February 2020

The study of religious and ideological features of Ukrainian ethno-confessional spirituality occupies an important place in the study of the process of Christianization of Rus-Ukraine. During the spread of Christianity in Russia, deep pagan traditions were synthesized with it. This phenomenon is called religious-pagan syncretism or the court.
Christianity of modern Ukraine: views through the prism of A.Richinsky's ethnological heritage
Authors: Pavlenko Pavlo Yuriyovych
Published: February 2020

Arseniy Rychinsky, unfortunately, belongs to the cohort of Ukrainian geniuses whose names have long been erased on the tables of Ukrainian history. Not widely known and therefore not popular in Ukraine, they still are. And it is unlikely that any of them would ever mind if it was already in an independent Ukraine - the one for which such patriots, including Arsen Rychynsky, only dreamed in their prayerful aspirations, the names and affairs of the great Ukrainian patriots, who by their martyrdom sacrificed themselves to the pantheon of apostles of Ukrainian custom, they will not be properly honored. The reason for this is too simple: such genius-patriots, like Captain Arsen and their creativity, are not particularly needed for this Ukraine, since they wrote about the greatness of the Ukrainian spirit, talked about Ukraine's special dreaming role in the world. In their faith in her divine destiny, they ignited the hearts of Ukrainians, turning them into prometheus of Ukrainian patriotism, plowmen of the field of Ukrainian national construction.
Ukrainian Orthodoxy from the View of A.Richinsky
Authors: Kolodnyi Anatolii M.
Published: February 2020

In printed editions and reports at scientific conferences there is sometimes a discussion about the legitimacy of the use of the term "Ukrainian Orthodoxy". It is said, in particular, that the term "Ukrainian Church" should be used, and not "Ukrainian Orthodoxy", because the former is allegedly used by Metropolitan Hilarion (Ogienko) and the latter is not. Some consider the use of the term "Ukrainian Orthodoxy" as another manifestation of "Ukrainian nationalism", because, see, Orthodoxy is a universal phenomenon and cannot be stretched "across national apartments" (though the authors of such considerations have long drawn it on its Russian nation and its Church as the sole savior of Orthodoxy). There were also warnings that in the Eastern Slavic territories there was no "proper Ukrainian Orthodoxy" there, but there was "Orthodoxy Russkoe" ("Russian", not "Russian"). agree with Arsen Rychinsky's opinion that every nation has its own separate path to God, and only in this way will he find happiness and justification that, by adopting "even one and the same religion, each nation finds in it something most relevant, closest ".
الإشكالیة في الحدیث “إن الله خلق آدم على صورتھ”: أسبابھا وحلولھا
Authors: Ramli Angraini binti
Published: February 2020

Hadith Innallāha khalaqa Adam ‘alā ṣūratih, is one of hadith that has isykāl (difficulties) or problems involving debates among scholars. Firstly, There are some scholars who argued that the problems in this hadith is because the pronunciation of ‘alā ṣūratih in this hadith is contrary to the Islamic faith. Secondly, Others argued that this hadith has a similarity with isrā’iliyāt because in the Torah and the Gospel also found similar things in the creation of Adam. Thirdly, some scholars accept this hadith textually but interpreted it to another meaning in order fit with holiness of Allah. The fourth,opinion argue that damiror pronoun of words on ‘alā ṣūratih refer to Allah, either as interpretation the word of rahman or as an iḍāfah taṣrīfiyah and ikhtiṣāṣiyah to Allah. The fifth, opinion argue that this damir refer to Adam. The sixth, opinion said that this damir returned to the owner face who was beaten as mentioned in the hadith is refer to the object which was hit, namely the face itself
RUMUS-RUMUS DALAM KITAB HADIS DAN RIJAL AL - HADIS
Authors: Husna Arinal
Published: February 2020

Buku saku ini menyajikan rumus-rumus dalam kitab hadis dan rijal al-hadis bagi para pembaca khususnya para mahasiswa, siswazah serta dosen-dosen universitas yang berkecimpung dalam bidang Ilmu Hadis yang ingin mengkaji kitab-kitab hadis. Didalam buku ini rumus-rumus tersebut disusun dalam bentuk bab per bab kemudian disetiap bab nya, rumus tersebut diklasifikasikan lagi menjadi beberapa macam.Untuk memudahkan pembaca dalam membedakan antar rumus-rumus tersebut, makarumus-rumus tersebut dimuat dalam bentuk tabel, dalam tabel tersebut penulis juga menjelaskan maksud serta penggunaan rumus tersebut. Tidak hanya itu, penulis terkadang juga menjelaskan hal-hal tertentu seperti kata kata istilah maupun sumber buku yang didapat dalam bentuk footnote.
Developing English Material of Agriculture for 7th Grade Students of SMP Plus Al-Mubarak Kalisat, Jember
Authors: Mahmud Mohammad , Sugiyono Sugiyono
Published: February 2020

A lot of seventh grade students of SMP Plus Al-Mubarak found many problems in understanding their English instructional materials. Designing English Materials of Agriculture for students in SMP Plus Al-Mubarak Kalisat, Jember can motive them in learning English better. Concerning these problems, a set of suitable instructional materials of English for the students of SMP Plus Al-Mubarak needed to be developed. In addition, instructional materials should facilitate the students to enrich their experience, build their knowledge, and construct their comprehension. The instructional materials should consider where the student’ life, culture, background, interest, and their ability. The procedures being employed in this study were RD (Research and Development); collecting information, developing instructional materials, conducting expert validation, revising the materials, finishing the submitted product. (Adapted from Borg and Gall’s Model, 1983). To collect relevant information for a basis of developing materials, the interview with the teacher and students and classroom observation were carried out to complete the information provided in the existing materials. The product of this research is five units of English materials of agriculture which focuses on second semester.
STUDENTS’ PERCEPTION ON ONLINE GAME MOBILE LEGENDS FOR VOCABULARY DEVELOPMENT
Authors: Dananjaya Adil , Kusumastuti Dyah
Published: February 2020

The purpose of this research is to discover the level of EFL students’ perception of online game Mobile Legends in their vocabulary development. The researcher used questionnaire and interview as the instrument to collect the data and took 20 respondents for the questionnaire and 5 interviewees that are taken from 8th semester students of English Education Department on 2018/2019 academic year in Universitas Muhammadiyah Purwokerto. This study got a positive result with 74%, therefore can be categorized as positive perception. Moreover, it was supported by the interview result where the interviewees agreed that their vocabulary knowledge is expanding when playing Mobile Legends.
Analysis of Matric Product Matching Between Cosine Similarity with Term Frequency-Inverse Document Frequency (TF-IDF) and Word2Vec in PT. Pricebook Digital Indonesia
Authors: Kusniyati Harni , Nugraha Arie Aditya
Published: February 2020

Consumers today have the option to purchase products from thousands of e-commerce. However, the completeness of the product specifications and taxonomies used to organize products differently in different electronic shop differently. To improve the consumer experience, Pricebook approach for integration of the product through the website to find the cheapest price from various platforms. In our writing, we do approach by using a model of neural language such as TF-IDF (term frequency-inverse document frequency) as well as Word2vec by using the method of cosine similarity. TF-IDF is a way to give the relationship a word weighting (term) against the document. Semantic vector or word embedding is one way to represent the structure of a sentence will be in align with manipulating sentences into vector shapes with Word2Vec. Cosine similarity method is a method to calculate the similarity between two objects that is expressed in two vectors by using keywords (keywords) of a document as the size so that it leads to more products matching good performance and categorization. In addition, we compare the results of the representation of the TF-IDF with Word2vec against a number of the data.
Expert System for Poultry Management
Authors: N. D. Oye , N. Jemimah
Published: February 2020

This research is aimed at developing a Software Framework for poultry management with the objectives: To provide poultry farmers with expert knowledge from the comfort of their homes. The system is developed using generic iterative waterfall model as methodology, HTML, CSS, JavaScript and Bootstrap for graphical user interface. PHP is used as programming language and MySQL as DBMS and normalization technique. The system is hosted locally for validation and testing on Xampp local host. The researchers recommended Poultry farmers to adopt and use the software framework because it can give knowledge on how to manage poultry expert system of different categories in poultry farming.
A Review Extended Release Oral Drug Delivery System and Multiparticulate Drug Delivery Systems (MDDS)
Authors: Khambat Swapnil B. , A. Kale. Shubham
Published: February 2020

The extended release product will optimize therapeutic effect and safety of a drug at the same time improving the patient convenience and compliance. By incorporating the dose for 24 hrs into one tablet/capsule from which the drug is released slowly. The concept of multiple unit dosage form was initially introduced in the early 1950’s.These forms play a major role in the design of solid dosage form processes because of their unique properties and the flexibility found in their manufacture. These forms can be defined as oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some desired characteristics. The release of drug from pellets depends on a variety of factors including the carrier used to form pellets and the amount of drug contained in them. Consequently, pellets provide tremendous opportunities for designing new controlled and extended release oral formulations, thus extending the frontier of future pharmaceutical development. The possible mechanism for drug release includes solution/diffusion through the continuous polymer phase or plasticizer channels, diffusion through aqueous pores and osmotically driven release through aqueous pores. To distinguish between these mechanisms, the release rate was studied as a function of coating thickness, plasticizer content and osmotic pressure in the dissolution medium.
Prenatal diagnosis of Jacobsen syndrome with cystic hygroma
Authors: Suzuki Toshifumi , Hayashi Takashi , Itakura Atsuo
Published: February 2020

Jacobsen syndrome (JBS) is a rare, contiguous genetic deletion syndrome caused by partial deletion of chromosome 11q. It is difficult to diagnose JBS by ultrasonography during the prenatal period because it has atypical clinical findings. Although nuchal thickening is associated with JBS, cystic hygroma has not been previously reported in conjunction with this syndrome. We describe the first prenatal diagnosis of JBS with cystic hygroma, which was clinically diagnosed at 13 weeks gestation in a Japanese woman, although it had not been detectable at the 11th week of gestation. In addition, a single ventricle fetal heart defect was suspected. Amniocentesis was performed, and G-banded karyotype evaluation revealed 46,XX,del(11)(q23), which is consistent with JBS. Cystic hygroma and congenital heart malformation have been reported to be associated with chromosomal anomalies. The present case indicates that a fetal cystic hygroma without increased nuchal thickness might be associated with JBS.
A First Record of Metal Fractionation in Coastal Sediment from Ambon Bay, Moluccas, Indonesia
Authors: Lestari Lestari , Budiyanto Fitri , Manullang Corry Yanti
Published: February 2020

Five metals in sediment samples at seven sites from the Ambon Bay were analyzed with BCR sequential extraction procedure to determine chemical fractionation of metals and to assess bioavailability of metals with Risk Assessment Code (RAC). The result showed that the percentages of cadmium (100%), lead (82.6-97.08%) and zinc (41.68-76.33%) were mostly accumulated in the non-residual (F1+F2+F3) fraction of the total concentrations. While the copper percentages (44.74-78.91%) and nickel (59.71-74.16%) were mostly accumulated in residual (F4) fraction of the total concentrations. The Risk Assessment Code (RAC) reveals that cadmium, copper, nickel and zinc at locations exist in acid soluble (exchangeable) fraction and therefore, they are in low until very high risk category meanwhile there is no Pb at locations exist in acid soluble (exchangeable) fraction.
Right to Water as a (Fundamental) Human Right
Authors: Đuras Ivana
Published: February 2020

Right to water as a fundamental human right
A History dedicated to Mehmed II? Kritoboulos of Imbros and the enshrining of a Superior's memory after the conquest of Constantinople in 1453
Authors: Szill Rike
Published: February 2020

This article examines the perception and productive acquisition of historical realities thereby questioning the imperative applicability of terms like "victory" or "defeat". This complex matter will be exemplified by an extremely controversial source: the ξυγγραΦή ίστοίων, the History of Kritoboulos of Imbros, an author who is notorious for being a biased admirer of Mehmed II. It will be argued that his work is not a mere product of Ottoman panegyric but a productive and innovative attempt to come to terms with the historical events on a broader scope. In this respect, it offers both an alternative explanatory approach and an innovative counter concept to Christian eschatology contributing to the literary discourse on the perception, interpretation and evaluation of the outcome of events. Hence, focal passages of Kritoboulos’ History such as the introductory letter of dedication and the general assault on Constantinople are analyzed.
Hemovigilância e a atuação da enfermagem em projeto de extensão: Relato de experiência
Authors: Carneiro Shayanna Mickaela Duque , Lima Maria Juraci de Oliveira
Published: February 2020

Objetivo: relatar as práticas vivenciadas pela acadêmica de enfermagem durante sua participação no projeto de extensão com foco em Hemovigilância. Método: estudo descritivo, tipo relato de experiência, onde o transcurso do projeto é descrito por meio de tópicos, compreendido entre outubro de 2018 a maio de 2019. Resultados: o projeto desenvolve –se com a finalidade de busca permanente na qualidade da assistência em hemoterapia através do fortalecimento da Hemovigilância no complexo da Universidade Federal do Rio Grande do Norte. Conclusão: entende-se que a construção de uma política de desenvolvimento instrucional atendendo as recomendações da Agência Nacional de Vigilância Sanitária, a realização de treinamentos periódicos, checklist, fluxogramas, criação de protocolos operacionais, entre outros, consolidam o papel da equipe multiprofissional quanto a hemovigilância
Correlation between certain rhythms of the body in osteopathic patients
Authors: Chernikova A. E. , Potekhina Yu. P.
Published: February 2020

Introduction.The time organization of the body is a set of biorhythms that have different periods, but are consistent with each other over time. Any pathology is an inconsistency of rhythms in the body. To date, the problem of the relationship between different rhythms of the human body is poorly studied. The largest number of publications is devoted to the connection between respiratory and heart rhythms. The goal of research — to identify the correlation between some rhythms of the body in osteopathic patients and the effect of osteopathic correction (OC) on them.

Materials and methods.100 patients of an osteopathic physician aged 8 to 81 years were examined (37 men and 63 women). All patients underwent a general osteopathic examination. The frequency of the cranial rhythm, the respiration rate (RR), the heart rate (HR), the neural process mobility (NPM) and the «connective tissue motility» were assessed before and after the OC session. Statistical processing of the results was carried out using nonparametric methods and the Statistica 10.0 program. The correlation coeffi cient between the frequencies of different rhythms was calculated by the Spearman method.

Results.On the whole, only one statistically signifi cant correlation was found in the group of examined patients — between RR and NPM (r =–0,33, p<0,05). After OC, the number of statistically signifi cant connections increased, which may indicate a benefi cial effect of OC on the rhythmic integrity of the patient′s body. In the group of children (8–15 years old) and young people (18–34 years old), three correlations between rhythms that can be considered as «normal» were revealed: negative correlation link between heart rate and PNP (r =–0,36, p<0,05), negative correlation link between HR and NPM (r =–0,58, p<0,05), positive correlation link between HR and RR (r =0,68, p<0,05). With age, these correlation links decrease, which can be explained by the alteration of regulatory processes and increase of desynchronosis. The higher is the level of dominant somatic dysfunction (local–regional–global), the lower are statistically signifi cant correlations between biorhythms. This means that the severity of desynchronosis increases. In global somatic dysfunctions and regional somatic dysfunctions of the head and dura mater there are no correlations between biorhythms, i. e. the most pronounced desynchronosis is observed in these groups of patients.

Conclusion.The correlation between some rhythms of the body in osteopathic patients was studied. The most pronounced desynchronosis is observed in global somatic dysfunctions and in regional somatic dysfunctions of the head and dura mater. After OC, the number of statistically signifi cant links between biorhythms increased.
Utjecaj e-komunikacije na podizanje razine učinkovitosti turističke destinacije grada Zagreba
Authors: Bilić Dinko
Published: February 2020

Svrha je
rada utvrditi važnost pristupa i zastupljenosti informacijskih i
komunikacijskih medija za turiste na turističkoj destinaciji Zagreb te
prevladava li i u kolikoj mjeri takva vrsta komunikacije u odnosu na neposrednu
komunikaciju s nositeljima
turističke ponude i građanima. Sastavni dio rada
čini provedeno kvantitativno istraživanje putem anketnog
upitnika među turistima na turističkoj destinaciji Zagreb u
razdoblju od rujna 2017. do veljače 2018. godine. U istraživanje su uključeni
turisti koji su boravili u svim gradskim četvrtima turističke destinacije grada
Zagreba, a popunjena su 202 anketna upitnika, od čega je 188 pravilno
popunjenih. Ispitanici su, među ostalim, ocjenjivali informiranost o postojećim
sadržajima destinacije, mogućnosti komuniciranja
na destinaciji te važnost i zastupljenost informacijsko-komunikacijskog
medija. Rezultati deskriptivne statističke analize pokazali su da turisti
pozitivno ocjenjuju informiranost i mogućnosti komuniciranja na destinaciji s
nositeljima ponude, no u ocjeni važnosti informativno-komunikacijskog medija
najvažnija je dostupnost interneta u smještajnim kapacitetima, restoranima i
drugim ugostiteljskim objektima za prehranu, kao i u kafićima i drugim
ugostiteljskim objektima. Rezultati istraživanja ukazali su na dodatna
promišljanja u definiranju mogućnosti koje u komunikaciji
nudi određena destinacija i uvođenja inovacija u postojeći komunikacijski
sustav.
Forming of source data for hydrodynamic model of lower Volga
Authors: Kizyaev Boris , Borodychev Victor , Buber Alina , Talyzov Alexey
Published: February 2020

The article describes methods for collecting and processing source data for building a computer model of the delta of river Volga and zones of western substeppe lakes (ilmens). With the help of the computer model being created, the calculated data describing the movement of water in a rivers and channels will be obtained. This information will be used to justify measures to improve the watering of the studied areas.
Analytical Study on the Effective Flange Width for T-shaped Shear Walls
Authors: Lu Nan , Li Weibin
Published: February 2020

This study was organized to derive simplified expressions to estimate the effective flange width for T-shaped shear walls at different loading stages. For that purpose, the variation in the effective flange width was explored by introducing dimensionless effective flange width coefficient. According to the principle of minimum potential energy, the theoretical expression of the effective flange width coefficient in the elastic stage was obtained. Furthermore, a parametric study considering the axial load ratio, height-width ratio of flange and width-thickness ratio of the flange, as well as the section aspect ratio was conducted to determine the effective flange width using verified nonlinear finite-element models. In light of the parametric analysis results, a formula model was proposed depending on the axial load ratio and height-width ratio of flange. Finally, the predictions of the proposed simplified formulas were verified with the theoretical solutions or finite element (FE) results, which indicated that the proposed formulas can accurately capture the effective flange width at the elastic, yield and limit state.
Правове регулювання ринку косметологічних послуг: порівняльно-правовий аналіз
Authors: Чеховська І. В. , Білоусюк В. В.
Published: February 2020

Стаття присвячена дослідженню правового регулювання ринку косметологічних послуг у країнах ЄС, США, Канаді й Україні. Виокремлено та узагальнено позитивний досвід такого правового регулювання в зарубіжних країнах. Доведено доцільність його запровадження в Україні, розроблено пропозиції щодо удосконалення вітчизняного законодавства, що регулює ринок косметологічних послуг.
Контролюючі суб’єкти у сфері бюджетного процесу: розмежування компетенційних повноважень
Authors: Мацелик Т. О. , Стріяшко Г. М.
Published: February 2020

У статті розглядаються проблеми розмежування компетенційних повноважень суб’єктів бюджетного контролю, зважаючи на соціально-економічні перетворення, які відбуваються в Україні. Наголошується, що необхідність та доцільність здійснення реформування контролю публічних фінансів безпосередньо пов’язані з адміністративними й адміністративнотериторіальними реформами, які перманентно відбуваються в Україні понад двадцять років. Зміни, що відбулися в країні в результаті зазначених реформ, вимагають кореляційних перетворень контролю у сфері публічних фінансів. Звертається увага на те, що окремі зміни в законодавстві щодо удосконалення контролю у сфері публічних фінансів носять несистемний характер та в цілому не сприяють підвищенню його ефективності. Акцентується увага на нагальній потребі формування ефективно взаємодіючої системи органів контролю у сфері публічних фінансів з єдиним координуючим органом, який забезпечуватиме нормативно-методологічну основу діяльності, належний інформаційний обмін та узгодженість дій органів контролю у сфері публічних фінансів з метою усунення дублювань заходів фінансового контролю та зменшення навантаження на підконтрольні суб’єкти. Запропоновані напрями вдосконалення системи органів бюджетного контролю.
Щодо модернізації вітчизняної системи управління податковими ризиками у контексті світового досвіду
Authors: Стародуб Д. М.
Published: February 2020

Система управління податковими ризиками передусім повинна забезпечувати якісний аналіз об’єктивних та суб’єктивних чинників податкових ризиків, ідентифікувати ризики, встановлювати взаємозв’язок між джерелами та видами податкових ризиків, оцінювати податкові ризики, а також мати належні засоби зменшення впливу податкових ризиків. Розбудова такої системи неможлива без врахування міжнародного досвіду
Поняття та значення управління публічними фінансами
Authors: Шолкова Т. Б.
Published: February 2020

Статтю присвячено визначенню такого методу фінансової діяльності держави, як управління публічними фінансами, окресленню його специфічних ознак, принципів його застосування, встановленню спільних та відмінних рис методу управління публічними фінансами у фінансовому праві з управлінням в адміністративному праві та державним управлінням з метою кращого розуміння правової природи цих процесів.
Підтримання державного обвинувачення як функція прокуратури в Україні та країнах ЄС
Authors: Антонюк А. Б. , Редчиць О. В.
Published: February 2020

Статтю присвячено висвітленню проблеми підтримання державного обвинувачення в Україні та деяких країнах ЄС на основі національного законодавства та міжнародних правових документів. Розкривається питання щодо обов’язків прокуратури під час реалізації функції обвинувачення та етапи цього процесу.
Тактичні операції, спрямовані на подолання протидії розслідуванню кримінальних правопорушень, вчинених з використанням сучасних інформаційних технологій
Authors: Завидняк І. О.
Published: February 2020

У статті розглядаються проблемні питання, які виникають у сфері протидії розслідуванню кримінальних правопорушень, вчинених з використанням сучасних інформаційних технологій. Звертається увага на методику розслідування цієї категорії правопорушень та форми протидії їх розслідуванню. Вказується на необхідність визначення завдань щодо подолання та нейтралізації протидії під час досудового розслідування кримінальних правопорушень, вчинених з використанням сучасних інформаційних технологій.