bluuebunny/crossref_metadata_2025 huggingface dataset:
Inferencia del origen del bovino criollo cubano a través del análisis de patri- y matrilinajes
Authors: Lirón J. P. , Acosta A. , Rogberg-Muñoz A. , Uffo O. , Posik D. M. , García J. , Peral García P. , Giovambattista G.
Published: March 2019

Antes de descubrimiento, no existían bovinos en América. Los primeros, fueron introducidos en la Antillas Mayores (La Española, Puerto Rico, Jamaica y Cuba), y desde allí trasladados al resto de Latinoamérica. Actualmente, existen en Cuba alrededor de 1300 bovinos Criollos, concentrados principalmente en la región oriental. Con el objetivo de analizar el origen materno de esta raza y detectar eventos contemporáneos de flujo génico por vía paterna, se analizó un fragmento de 240 pb del D-loop mitocondrial (mtADN) y 5 microsatélites del cromosoma Y (BTY), en 36 hembras y 21 machos respectivamente. La diversidad genética se estimó mediante el número de haplotipos, el número de sitios polimórficos, el número de diferencias nucleotídicas entre pares de secuencias y el índice de diversidad nucleotídica, mientras que el análisis filogenético se realizó utilizando el método de median joining network. Dicho análisis permitió detectar 15 haplotipos mitocondriales (10 del haplogrupo europeo T3, 3 del africano T1, 1 del cercano oriente T2 y 1 ambiguo T1-T3) y 3 haplotipos en el BTY, ambos del haplogrupo cebuíno Y3. En el mtADN se detectaron 23 sitios polimórficos con una diversidad nucleotídica de 0,014 y 3,36 diferencias medias entre pares de secuencias. En conclusión, la población de bovinos Criollos Cubanos presentó una composición haplotípica mitocondrial comparable a la de otras razas criollas y mediterráneas, hecho que concuerda con su origen histórico. El BTY evidenció altos niveles de introgresion paterna de genes del zebú.
Características de produção do capim-buffel submetido a intensidades e freqüências de corte
Authors: Edvan R. L. , Santos E. M. , Da Silva D. S. , De Andrade A. P. , Costa R. G. , Vasconcelos W. A.
Published: March 2019

Objetivou-se avaliar características morfogê-nicas, estruturais e a produção de biomassa do capim-buffel sob intensidades e freqüências de corte. Utilizou-se um pasto já implantado de capim-buffel, cultivar Molopo. A área total utilizada foi dividida em 20 parcelas de 8 m2 cada com linha de bordadura de 1 m entre as parcelas. Foi utilizado um esquema de parcelas subdivididas no tempo, tendo nas parcelas um arranjo fatorial 2x2 referente a combinações entre duas alturas de corte (60 e 80 cm) e duas alturas de resíduo (20 e 40 cm), em delineamento experimental de blocos completos ao acaso, com cinco repetições, totalizando 20 unidades experimentais, que receberam as denominações 20-60, 20-80, 40-60, 40-80. Houve efeito (p
Caracterización sanitaria y nutricional de colonias de abejas melíferas en forestaciones de Eucalyptus grandis
Authors: Invernizzi C. , Santos E. , García E. , Daners G. , Di Landro R. , Saadoun A. , Cabrera C.
Published: March 2019

En Uruguay muchos apicultores trasladan sus colonias a las forestaciones de Eucalyptus grandis al final del verano y en otoño obteniendo importantes cosechas de miel. Sin embargo, cuando finaliza la floración las colonias se encuentran muy debilitadas, sobreviniendo una elevada mortalidad. Problemas nutricionales y sanitarios podrían explicar el debilitamiento de las colonias. Para averiguar las causas del debilitamiento se llevaron colonias de igual tamaño a una forestación de E. grandis, separadas en tres grupos diferenciados por la disponibilidad de polen. A lo largo del periodo de floración se registró: el origen botánico y el contenido de proteína cruda del polen que ingresaba en las colmenas, la proteína corporal de las abejas, la infección por Nosema ceranae y la infestación por Varroa destructor, el área de cría y la producción de miel. Los resultados más importantes hallados fueron: i) la sostenida disminución de la diversidad botánica del polen a medida que transcurría el periodo de floración de E. grandis hasta quedar únicamente el polen de esta especie; ii) el polen de E. grandis presentó valores de proteína bruta cercanos al 30%, pero fue disminuyendo paulatinamente hasta alcanzar un valor inferior a 20% al final de la floración; iii) las colonias que contaban inicialmente con reservas de polen presentaron abejas con mayor proteína corporal pocos días después de llegar a la forestación y menor infestación de N. ceranae durante la mayor parte del periodo de floración; iv) la disponibilidad de polen no incidió en la infestación de V. destructor, el área de cría y la producción de miel. El déficit nutricional de las abejas durante la floración de E. grandis podría generar las condiciones adecuadas para la multiplicación de N. ceranae. Al final de la floración del eucalipto las colonias presentaron promedialmente más del 90% de las abejas pecoreadoras infectadas con N. ceranae y 12% de V. destructor en las abejas adultas. La incidencia de ambos patógenos sobre las abejas debilitadas podría explicar la pérdida de colonias.
Integridad de membrana y cromatina espermática en caprinos con y sin bipartición escrotal
Authors: Salviano M. B. , Souza J. A. T. , Vidigal K. F. , Cavalcante T. V. , Sarria-Perea J. A. , Lopes F. B.
Published: March 2019

Se cree que el escroto bipartido de caprinos de regiones áridas y semiáridas mejora la calidad del semen al contribuir a la regulación térmica intratesticular. Se evaluó la calidad del semen y de los espermatozoides de cuatro machos cabríos con escroto entero y tres con escroto bipartido, por medio de análisis convencionales, membrana plasmática y cromatina de los espermatozoides. Los espermatozoides de animales con escroto bipartido presentan mejor calidad física y morfológica, lo cual sugiere mejor adaptación a climas áridos y semi-áridos.
Tasa de ovulación sincronizada con PGF2A y dinámica folicular en vacas criollo lechero tropical
Authors: Guerrero H. L. J. , Pérez-Hernández P. , López-Ortiz S. , Montiel Palacios F. , Estrella-García A. , Ahuja Aguirre C.
Published: March 2019

Se sincronizó el estro en 36 vacas Criollo Lechero Tropical (CLT) cíclicas y lactantes utilizando PGF2a y se determinó el momento de inicio y final del estro, y el tiempo (TO) y tasa de ovulación (TAO). Posteriormente, durante el ciclo estrual natural siguiente al sincronizado se determinó la dinámica folicular (DF) y la duración del ciclo (DC). El TO después del final del estro sincronizado fue 16,5±3,6 h y la TAO 100%. En el ciclo estrual natural, 93% de vacas presentó tres ondas foliculares y 7% dos ondas, y la DC fue 22 y 19 días, respectivamente. Las vacas CLT mostraron buena respuesta a la sincronización con PGF2a, y la DF y DC fueron similares a otras razas Bos taurus productoras de carne y lecheras.
Petrophysical Evaluation of Organic Richness and Brittleness of Shale for Unconventional Hydrocarbon Prospecting: A Case Study on Vadaparru Shale, Krishna Godavari Basin, India
Authors: Sahu Arijit , Das Milan Kanti
Published: March 2019

Objective

Shale has been a major destination for unconventional hydrocarbon resources for its wide stratigraphic coverage as well as high volumetric hydrocarbon potential. Contemporary success in North American shale plays has intrigued operators worldwide in shale exploration. Organic richness has been a key factor to determine the potential of shale as it is proportional to the amount of hydrocarbon likely to be generated and stored in available spaces within the shale. The other important factor in this context is shale brittleness as it indicates how fracable the potential shale is. Attempts are made here by strategically using standard wireline logs in order to evaluate potential of Eocene Vadaparru Shale in Krishna Godavari Basin, India qualitatively and quantitatively.

Methods

The technique used in this study involves identification of organic lean ‘clean shale’ interval and establishing a ‘clean shale’ relation of resistivity as a function of compressional sonic transit time in the study wells, as both the logs respond comparably to shale and its organic content. Using this relation a proxy ‘clean shale’ resistivity log is generated in shale and compared with measured wireline resistivity. A positive separation between calculated and measured resistivity is then assessed as proportionate shale organic richness, owing to the presence of relatively less dense (corresponding to longer sonic transit time) and more resistive organic content. Shale brittleness is predicted from Young's modulus and Poisson's ratio using compressional, shear and Stoneley wave velocities obtained from sonic measurements, assuming transversely isotropic nature of Vadaparru Shale.

Results

The Eocene marine transgressive Vadaparru Shale is a dominant stratigraphy in KG basin as evident from seismics and drilling. Petrophysical analyses in study wells indicated appreciable brittleness within Vadaparru Shale. The organic richness i.e. amount of positive separation between calculated and measured resistivity combined with brittleness quantitatively indicate fair to excellent unconventional potential of Vadaparru Shale. Considerable thickness, Type-II, III kerogen content and geochemical measurements support the study and highlight it as a promising ‘shale reservoir’ destination. In the context of rapidly growing energy demand of India Vadaparru Shale can be considered as serious unconventional player.

Novelty

Overall this study presents quick strategy for shale potential quantification, thus allowing operators to focus spatially in the quest of unconventional hydrocarbon resources.
Cytokine profiling reveals increased serum inflammatory cytokines in idiopathic choroidal neovascularization
Authors: Guo Shenchao , Yin Houfa , Zheng Mingjie , Tang Yizhen , Lu Bing , Chen Xinyi , Fu Qiuli , Qin Zhenwei , Lyu Danni , Tang Qiaomei , Zhang Lifang , Ma Jian , Zhang Li , Fang Xiaoyun
Published: March 2019

Background: The exact pathogenesis of idiopathic choroidal neovascularization (ICNV) remains unclear. Cytokine-mediated inflammation has been thought to be involved in the pathophysiology of ICNV. The purpose of this study was to investigate serum cytokine profiles in patients with ICNV and to explore the relationship between serum cytokine levels and ICNV severity.
Methods: This case-control study was conducted in 32 ICNV patients and 30 healthy volunteers. Clinical and demographic information was obtained from the medical data platform and the serum was analysed with a multiplex assay to determine the levels of seven cytokines: interleukin (IL)-2, IL-10, IL-15, IL-17, basic fibroblast growth factor (basic FGF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF).
Results: Serum levels of IL-2, IL-10, IL-17, basic FGF, and VEGF were elevated in ICNV patients compared to controls. Serum GM-CSF levels were positively related to central retinal thickness, and serum IL-17 levels were positively related to CNV lesion area.
Conclusion: Serum inflammatory cytokines were significantly elevated in ICNV patients compared to controls. This suggests that systemic inflammation may play a critical role in the physiopathology of ICNV.
Patient reported outcome after stemmed versus stemless total shoulder arthroplasty for glenohumeral osteoarthritis: a patient-blinded randomized clinical trial
Authors: Issa Zaid , Rasmussen Jeppe Vejlgaard , Petersen John Kloth , Schantz Kim , Brorson Stig
Published: March 2019

Background
Stemless shoulder arthroplasty systems with uncemented metaphyseal fixation have been used in Europe for glenohumeral osteoarthritis since 2004 [1]. The stemless design has several theoretical advantages compared with the stemmed shoulder arthroplasty systems: restoring patients’ anatomy, preserving humeral bone stock, and few complications in component removal if the need for a revision arthroplasty arises. The purpose of the study is to compare the short-term, patient-reported outcome of stemless and stemmed total shoulder arthroplasty.

Materials and methods
A randomized clinical trial will be conducted. Eighty patients with clinical and radiological signs of primary or posttraumatic glenohumeral osteoarthritis, computerized tomography (CT) scan-verified adequate glenoid bone stock, and no total rupture of rotator cuff tendons verified by a magnetic resonance imaging (MRI) scan will randomly be allocated to a stemless or stemmed total shoulder arthroplasty (TSA). The primary outcome will be the Western Ontario Osteoarthritis Shoulder (WOOS) score at 12 months. Secondary outcomes are the WOOS score at three months and the Oxford Shoulder Score (OSS) and EQ-5D at 3 and 12 months. All complications, including glenoid and humeral component loosening, instability, rotator cuff tear, intraoperative and postoperative periprosthetic fracture, nerve injury, infection, deltoid injury, and symptomatic deep venous thrombosis, will be reported.

Discussion
Findings will provide patients with better information about the potential benefits and harms of stemless and stemmed total shoulder arthroplasty and will assist shoulder surgeons and patients in decision-making.
Assessing the Response of Tomato Yield, Fruit Composition, Nitrogen Absorption, and Soil Nitrogen Fractions to Different Fertilization Management Strategies in the Greenhouse
Authors: Duan Pengpeng , Sun Ying , Zhang Yuling , Fan Qingfeng , Yu Na , Dang Xiuli , Zou Hongtao
Published: March 2019

A greenhouse field experiment involving tomato (Solanum lycopersicum) was performed using different nitrogen (N) management regimes: sole application of differing rates of chemical N fertilizer (SC) (SC treatments: N0, N1, N2, and N3) and combined application of manure and chemical N fertilizer (MC) (MC treatments: MN0, MN1, MN2, and MN3). These were used to understand the relationship between comprehensive fruit composition, yield, and N fractions (soil mineral N; soil soluble organic N; soil microbial biomass N, and soil fixed ammonium) under greenhouse conditions. The results showed that the MC treatments significantly increased vitamin C and soluble sugar content compared with SC treatments. In addition, the MN2 treatment produced a high yield and had a positive effect on fruit composition. The N3 (563 kg N/ha) and MN3 (796 kg N/ha) treatments resulted in a high loss of N below the root zone (0–30 cm), consequently reducing N use efficiency. Soil mineral N, soil soluble organic N, and soil fixed ammonium tended to be higher during the first fruiting period, whereas soil microbial biomass N tended to be higher during the second fruiting period. MC treatments significantly increased the N fraction in the 0- to 30-cm soil layer; N fractions tended to be higher with the MN2 treatment. According to an optimum regression equation, soil fixed ammonium during the first fruiting period and soil microbial biomass N during the second fruiting period had a more significant influence on tomato yield and fruit composition. Overall, application MC at an appropriate rate (MN2: 608 kg N/ha) is a promising approach to achieving high yields and optimum taste, and it offers a more sustainable fertilizer management strategy compared with chemical N fertilization.
GIBBERELLIN INSENSITIVE DWARF1 Plays an Important Role in the Growth Regulation of Dwarf Apple Rootstocks
Authors: Hao Suxiao , Lu Yanfen , Liu Jing , Bu Yufen , Chen Qi , Ma Nan , Zhou Zhiqin , Yao Yuncong
Published: March 2019

Dwarfing rootstocks can improve the plant architecture of apple trees and increase production. Gibberellins (GAs) are crucial for plant growth and dwarfing traits. The receptor, GIBBERELLIN INSENSITIVE DWARF1 (GID1), plays an important role in the regulation pathway. However, the growth regulatory mechanism of GID1 in dwarf apple rootstock seedlings is not clear. In this study, we selected dwarf apple rootstock ‘SH6’ and its cross parents as materials to clone the GA receptor gene GID1c. There were two different sites in the alpha/beta hydrolase domain. The expression of GID1c in ‘SH6’ was lower than that in Malus domestica cv. Ralls Janet, with the decrease of GA content. We further conducted GA3 treatment and overexpression of GID1c in tissue culture seedlings of ‘SH6’, and the results showed that the expression of GID1c and biosynthesis genes increased and promoted the accumulation of hormone contents, which ultimately regulates the growth of ‘SH6’ dwarf apple rootstock seedlings. Our results suggest that GID1c may affect the plant architecture and dwarf traits of dwarfing rootstock and accelerate its application in orchards.
Management of hypochlorite solutions used for water treatment in small drinking water systems
Authors: Coulombe Louis , Legay Christelle , Sérodes Jean , Rodriguez Manuel J.
Published: March 2019

Hypochlorite solutions (HSs), also called liquid chlorine, are widely used as disinfectants during drinking water treatment and distribution. However, the decomposition of the hypochlorite ion results in the formation of undesirable inorganic contaminants such as chlorite, chlorate, bromate and perchlorate. While HS decomposition cannot be completely avoided, it can be minimized through applying adequate practices during the purchasing, handling and storage of such solutions. This article presents the results of an investigation of the management of HS in water treatment plants (WTPs) in small municipalities. The data concerning HS management were acquired through field visits and semi-structured interviews with operators and managers of the small WTPs. The information gathered about HS management practices was compared to best management practice guidelines. Results show that practices involving HS differ between WTPs and that there are important gaps in the application of the existing HS management guidelines. The research revealed that the implementation of specific guidelines for the purchasing, handling and storage of HS is difficult for small WTPs due to the lack of human resources, expertise, and education, as well as a lack of infrastructure capacity.
DO ESQUADRINHAMENTO AO BATE-PAPO
Authors: Sampaio Fabrício de Sousa
Published: March 2019

A paquera pode ser definida como um processo de busca por alguém com intenção amorosa ou sexual. Atualmente, o ato de paquerar entre homens do “off-line” é mediado e modificado pelas mídias digitais. A discussão que constitui este artigo parte do princípio de que a paquera de forma geral se constitui em um continuum off/online articulado e independente característico do mundo social na atualidade. E no tocante aos enlaces homossexuais, a paquera não é algo impetuoso, voluntarista e desregrado. Ao contrário, no decorrer da etnografia ela se mostrou ritualística. Assim, o presente artigo é constituído pelas reflexões preliminares de uma etnografia em andamento no contexto “on-line” do Facebook, cujo objetivo principal é analisar os rituais da paquera entre homens e os seus significados socialmente constituídos. Ritual, performances de gênero, corpo e sexo constituem as chaves de interpretação do objeto em estudo.
PATRÕES E CATIVOS
Authors: Alencar Edna F.
Published: March 2019

O artigo analisa as relações de trabalho e formas de resistência nos seringais da região do Alto Solimões, Amazonas, a partir das narrativas de pessoas que residem nessa região. O objetivo é compreender como os sujeitos administram os “espólios de memórias” para compor uma narrativa sobre o passado onde se destacam os seringalistas, agentes da modernidade e da violência; e os seringueiros situados nos estratos mais baixos da hierarquia social, trabalhando na condição de cativos. A análise evidencia como sujeitos situados em diferentes posições da estrutura social percebem e examinam os fatos do passado. Os ex-seringueiros denunciam a violência perpetrada pelos patrões que marcou o trabalho e a vida na sociedade do seringal, as resistências cotidianas e silenciosas a essa dominação. Os herdeiros dos seringalistas valorizam seu papel como agentes do desenvolvimento econômico e social. Conclui-se mostrando que as estratégias de resistência adotadas pelos seringueiros para realizar o projeto familiar fundavam-se na sabotagem, ao adicionar impurezas à borracha ou vender parte da produção para comerciantes concorrentes dos seringalistas, os regatões, que lhes forneciam as condições para resistir ao domínio dos patrões.
GÉNERO-GRAFÍAS SANITARIAS ALGUNAS REFLEXIONES EN TORNO A UNA INTERVENCIÓN PERFORMÁTICA EN BAÑOS PÚBLICOS
Authors: Fernández Daniel Fernández , Arias Mariangela Pluchino
Published: March 2019

El baño constituye una instancia privilegiada para el marcaje de los cuerpos y la segregación espacial del género; la normativización que rige nuestra actuación continuamente en esos higiénicos recintos, opera sobre una base que anula cualquier signo de ambigüedad, que se ve reforzada por una serie de arreglos espaciales y normativas institucionales, así como de acuerdos implícitos, es decir, de lo dicho y lo no dicho. Siguiendo la analítica foucaultiana del discurso, nos dedicaremos a abordar algunas de las diﬁcultades que conllevan ese estamento público que supone el baño, así como sus arreglos tácitos. El presente texto busca identiﬁcar y analizar estos elementos en el contexto costarricense, para lo cual se utilizará la experiencia que tuvimos las personas sustentantes de la presente propuesta en el marco del día por la despatologización de las identidades trans (25/10/13), en el cual se llevó a cabo una intervención directa en baños públicos de la Universidad de Costa Rica, generando todo tipo de reacciones adversas que dan pie a algunas de las reﬂexiones aquí compiladas.
A ECLOSÃO DO COLONIAL EM NOSSO COTIDIANO
Authors: Oliveira João Pacheco de
Published: March 2019

Transcrição da Conferência de João Pacheco de Oliveira na Semana de Antropologia UFRN 2017, realizada por Cristina Diógenes Souza Bezerra, revisada por Angela Facundo e pelo autor.
UMA ANTROPOLOGIA TRAÇADA PELA PAIXÃO
Authors: Assunção Luiz
Published: March 2019

O presente memorial é uma versão resumida do texto apresentado em novembro de 2014 ao Centro de Ciências Humanas, Letras e Artes da UFRN como parte dos requisitos para a ascensão à classe de professor titular na carreira do magistério superior.
Integrons and Antiseptic Resistance Genes Mediate Resistance of Acinetobacter baumannii and Pseudomonas aeruginosa Isolates from Intensive Care Unit Patients with Wound Infections
Authors: Elkhatib Walid F. , Khalil Mahmoud A.F. , Ashour Hossam M.
Published: March 2019

Background:

Acinetobacter baumannii and Pseudomonas aeruginosa are of major concern for hospitalized patients.

Methods:

We evaluated antibiotic and antiseptic resistance of A. baumannii (n = 29) and P. aeruginosa (n = 37) isolates recovered from 66 intensive care unit (ICU) patients and determined the prevalence of qacE, qacEΔ1, and integrons in these clinical isolates. Antibiotic and antiseptic susceptibility testing was performed via Kirby Bauer disk diffusion and broth microdilution methods, respectively. The resistance genes and integrons were detected by PCR. A. baumannii and P. aeruginosa ICU isolates showed 100% and 70.3% antibiotic multiple drug resistance patterns, respectively.

Results:

The isolates also revealed high levels of resistance (MIC ≥ 16 µg/ml) against antiseptics commonly used in Egyptian hospitals (Benzalkonium, Benzethonium, and Chlorhexidine). The qacEΔ1 gene showed higher levels of prevalence in both A. baumannii and P. aeruginosa isolates (93.5% and 78%, respectively) as compared to that of qacE gene (52.0% and 33.0%, respectively). The intI1 was more prevalent among A. baumannii isolates (65.5%) compared to P. aeruginosa isolates (37.8%). P. aeruginosa resistance genotypes were significantly associated with antibiotic and antiseptic resistance patterns. A. baumannii resistance genotypes were associated with antiseptic-resistance patterns.

Conclusion:

The excessive usage of antiseptics may escalate bacterial resistance, especially with high prevalence of intI1 integron in these pathogens.
Therapeutic Strategies Targeting Amyloid-β in Alzheimer’s Disease
Authors: Pinheiro Lídia , Faustino Célia
Published: March 2019

Alzheimer’s disease (AD) is a neurodegenerative disorder linked to protein misfolding and aggregation. AD is pathologically characterized by senile plaques formed by extracellular Amyloid-β (Aβ) peptide and Intracellular Neurofibrillary Tangles (NFT) formed by hyperphosphorylated tau protein. Extensive synaptic loss and neuronal degeneration are responsible for memory impairment, cognitive decline and behavioral dysfunctions typical of AD. Amyloidosis has been implicated in the depression of acetylcholine synthesis and release, overactivation of N-methyl-D-aspartate (NMDA) receptors and increased intracellular calcium levels that result in excitotoxic neuronal degeneration. Current drugs used in AD treatment are either cholinesterase inhibitors or NMDA receptor antagonists; however, they provide only symptomatic relief and do not alter the progression of the disease. Aβ is the product of Amyloid Precursor Protein (APP) processing after successive cleavage by β- and γ-secretases while APP proteolysis by α-secretase results in non-amyloidogenic products. According to the amyloid cascade hypothesis, Aβ dyshomeostasis results in the accumulation and aggregation of Aβ into soluble oligomers and insoluble fibrils. The former are synaptotoxic and can induce tau hyperphosphorylation while the latter deposit in senile plaques and elicit proinflammatory responses, contributing to oxidative stress, neuronal degeneration and neuroinflammation. Aβ-protein-targeted therapeutic strategies are thus a promising disease-modifying approach for the treatment and prevention of AD. This review summarizes recent findings on Aβ-protein targeted AD drugs, including β-secretase inhibitors, γ-secretase inhibitors and modulators, α-secretase activators, direct inhibitors of Aβ aggregation and immunotherapy targeting Aβ, focusing mainly on those currently under clinical trials.
Cardiac Murmurs in Children: A Challenge For The Primary Care Physician
Authors: Kostopoulou Eirini , Dimitriou Gabriel , Karatza Ageliki
Published: March 2019

:

Congenital heart disease is present in almost 1% of live births and despite current progress in prenatal screening a significant percentage has delayed diagnosis or remain undiagnosed. A cardiac murmur may be the first or unique clinical sign of congenital heart disease in childhood, however, less than 1% of auscultated murmurs are of an organic cause.

:

Distinguishing between an innocent and a pathologic murmur can be challenging and the experience of the examiner is crucial for identifying the distinctive properties of an innocent murmur. Timely diagnosis of underlying cardiovascular pathology is of great significance so that prompt management is provided and morbidity or mortality are restricted. Of similar importance is the avoidance of unnecessary anxiety for the parents and unreasonable referrals to Paediatric Cardiologists. Indications for referral include a medical history suggestive of a cardiac abnormality, such as the presence of relevant symptoms, the identification of abnormal findings on clinical examination, auscultatory findings suggestive of an organic murmur, and very young patient age. ECG and a chest X-ray are not usually part of the diagnostic approach of a child with a cardiac murmur, as they do not increase the success rate of diagnosing heart disease, as compared to a detailed medical history accompanied by a thorough physical examination.

:

In conclusion, the recognition of suspicious distinctive features of cardiac murmurs is crucial and requires skills based on sufficient training and experience.
Dinuclear Copper(II) 3,4,5-Tri-O-benzylgallate
Authors: Mikuriya Masahiro , Yamakawa Chihiro , Masuda Naoyuki , Yoshioka Daisuke , Yamaguchi Sayuri , Yamada Hidetoshi , Mizuta Tsutomu , Kawata Naomi , Tanaka Hidekazu , Handa Makoto
Published: March 2019

Background:

Ellagitannins have attracted much attention because of the biological and pharmacological activities. In the total synthesis of ellagitannins, 3,4,5-tri-O-benzylgallic acid has been a key compound to introduce the protected galloyl group. From the perspective of coordination chemistry, 3,4,5-tri-O-benzylgallic acid is an interesting carboxylate ligand which might be capable of dinuclear carboxylate complex. Such a dinuclear carboxylate complex might be interesting as a new example of copper acetate type complexes.

Objectives:

The objective of the work is to synthesize a copper acetate type complex by using 3,4,5-tri-O-benzylgallic acid and to see a new feature of copper acetate compounds, by elucidating the crystal structure, magnetic property, and adsorption property for N2gas.

Methods:

Copper(II) 3,4,5-tri-O-benzylgallate has been synthesized by a reaction of 3,4,5-tri-O-benzylgallic acid and copper(II) nitrate at pH=9 condition. The isolated complex was characterized using single-crystal X-ray structure analysis, XRD analysis, UV-visible spectroscopy, IR spectroscopy, and temperature dependence of magnetic susceptibility.

Results:

The crystal structure shows a crystallographically centrosymmetric dinuclear molecule with four carboxylato-bridges and axial dimethylformamide molecules and crystal dmf molecules [Cu···Cu 2.6345(12) Å]. In the crystal, 1D supramolecular assembly by π-π interaction between the benzyl aromatic rings of dinuclear molecules was observed. Temperature dependence of magnetic susceptibilities showed a considerable antiferromagnetic interaction between the two copper(II) ions (2J = –214 cm–1). Type-II gas-adsorption property was observed for N2.

Conclusion:

A key-compound for the total synthesis of ellagitannins, 3,4,5-tri-O-benzylgallic acid (Htbng), was shown to be a new ligand for the synthesis of dinuclear copper acetate analogue with a lantern-type core, extending the realm of copper acetate clusters.
Co-Delivery Nanosystems for Cancer Treatment: A Review
Authors: Eftekhari Reza Baradaran , Maghsoudnia Niloufar , Samimi Shabnam , Zamzami Ali , Dorkoosh Farid Abedin
Published: March 2019

Massive data available on cancer therapy more than ever lead our mind to the general concept that there is no perfect treatment for cancer. Indeed, the biological complexity of this disease is too excessive to be treated by a single therapeutic approach. Current delivery systems containing a specific drug or gene have their particular opportunities and restrictions. It is worth noting that a considerable number of studies suggest that single- drug delivery systems result in insufficient suppression of cancer growth. Therefore, one of the main ideas of co-delivery system designing is to enhance the intended response or to achieve the synergistic/combined effect compared to the single drug strategy. This review focuses on various strategies for co-delivery of therapeutic agents in the treatment of cancer. The primary approaches within the script are categorized into co-delivery of conventional chemotherapeutics, gene-based molecules, and plant-derived materials. Each one is explained in examples with the recent researches. In the end, a brief summary is provided to conclude the gist of the review.
REVISITING THE DETERMINANTS OF STUDENTS’ SUCCESS IN CONDUCTING CREATIVITY PROGRAM
Authors: Sumaryanto Sumaryanto , Kasse Tchello , Putro Nur Hidayanto Pancoro Setyo
Published: March 2019

This study investigated the determinants of students’ success in completing creativity programs. A survey design was used in this study. A total of 351 respondents completed a survey on the factors that theoretically were related to students’ creativity. Exploratory factor analysis (EFA) was then conducted to explore the factors that emerge as the correlates of students self-efficacy in completing the creativity program. Subsequently, confirmatory factor analysis (CFA) was performed to confirm the pattern proposed in the EFA. Finally, Structural Equation Modelling with Mplus was conducted to explore how the factors are related to students self-efficacy in completing the creativity program. The results showed that students’ self-efficacy are strongly related to the role of their advisors, supports from their research community, and supports from the university. Comprehensive discussions on these factors are provided throughout this paper.
ISPARTA KILIÇ ÖREN MEVKİİNDE BİR KAÇAK KAZI ALANINDA ELEKTRİK ÖZDİRENÇ TOMOGRAFİ ARAŞTIRMASI
Authors: YILMAZ Sedat , ÖKSÜM Erdinç , ÇAKMAK Olcay
Published: March 2019

Isparta Kılıç Ören mevkiinde kaçak kazı sonucu Roma
dönemi mimarisine ait olduğu düşünülen gömülü anıtsal bir kalıntı ortaya
çıkmıştır. Bu kalıntının sürekliliğini ve kazı etrafında gömülü olası
kalıntıları belirlemek için iki bölgede toplam 20 profilde Wenner-Schlumberger
dizilimine göre elektrik özdirenç tomografi ölçümleri gerçekleştirilmiştir.
Ölçülen saha verilerini değerlendirmede kullanılan yazılım iki farklı ters
çözüm yöntemi seçeneği sunmaktadır. Bu iki yöntemin yeterliliği yaygın elektrot
dizilimleri için sentetik arkeolojik modeller kullanılarak test edilmiştir.
Kullanılan arkeolojik modeller (blok ve yatay silindir), gömülü yapı
kalıntılarına karşılık gelen duvarları ve sütunları temsil etmektedir. Sentetik
model sonuçları, arkeoloji sahasından ölçülen özdirenç verilerin yorumlanmasına
katkılar sağlamıştır.
TEMEL OTURMA HESAPLARINDA GELENEKSEL YÖNTEM VE SONLU ELEMANLAR YÖNTEMİNİN KARŞILAŞTIRILMASI
Authors: KESKİN Sıddıka Nilay , CENGİZHAN Akten
Published: March 2019

Bu
çalışmada, farklı zemin profilleri ele alınarak temellerin oturma hesabı için
gerekli tüm laboratuvar deneyleri yapılmıştır. Bu deneyler sonucunda zemin
profillerinin oluşturulmasından sonra temelde geleneksel yöntemle konsolidasyon
oturması hesapları yapılmıştır. Aynı veriler kullanılarak PLAXIS 3D üç boyutlu sonlu
eleman paket programı ile sayısal analizler gerçekleştirilmiştir. Geleneksel
yöntemle ve sonlu elemanlar analizlerinden elde edilen sonuçlar birbirleriyle
karşılaştırılmış grafik olarak sunulmuştur. Bu karşılaştırmaların sonucunda
temellerin oturma miktarının hesaplanmasında geleneksel yöntem yollarıyla sonlu
elemanlar paket programı analizleri birbirine çok yakın sonuçlar vermiştir. Bu
sonuçlara bakılarak hata payının %1’den az olduğu gözlemlenmiştir.
KÜRESEL EYLEYİCİNİN ROTOR MIKNATIS MALZEMESİ VE STATOR SARGI GEOMETRİSİNİN EYLEYİCİ TORKUNA ETKİSİ
Authors: DALCALI Adem
Published: March 2019

Klasik elektrik motorları tek serbestlik derecesinde hareket kabiliyetine sahip motorlardır. Çok serbestlik derecesinde hareket gerçekleştirmek istendiğinde birden çok klasik motorun kullanımı söz konusudur. Bu durumda toplam verimin azalması ile sonuçlanmaktadır. Birden fazla serbestlik derecesine sahip olan küresel eyleyiciler çok serbestlik dereceli hareketlerin yapılmasında tercih edilebilirler. Bu çalışmada, yüksek tork yoğunluğuna sahip sabit mıknatıslı bir küresel eyleyicinin 3 boyutlu tasarımı ve sonlu elemanlar metodu kullanılarak manyetostatik analizi gerçekleştirilmiştir. Eyleyiciden düşük hacimde yüksek tork elde edilmesi amacıyla, rotor mıknatıs malzemesi ve stator sargısının fiziksel yapısının optimize çalışmaları yapılmıştır. Yapılan optimizasyon çalışmaları sonucunda mıknatıs malzemesi olarak N50m tipi mıknatıs malzemesi tercih edilmiştir.
ROBOTIC SURFACE MATERIAL RECOGNITION SYSTEM USING SENSOR NETWORK
Authors: GÖKCAN Salih Ertuğrul , KAHRAMAN Nihan
Published: March 2019

Object recognition usually includes colour, shape and material types. This paper presents a methodology for surface material recognition by a tool which is tapped on an object for robotic applications. Recognition of a surface material can be explored by scratching the tip of the tool over the surface. To classify surface types, many different sensors such as acceleration, force, reflectance, image and audio were used via automated robot movements. For this purpose, 28 different surface materials including such as metals and papers were used. It should be emphasized that the properties of surface materials are also different. 22 different classifiers were trained with these surfaces using Matlab Classification Learner Application. The data which is collected ten times from sensors were examined also in different combinations. First, all data (combination of acceleration, force and reflectance) except image and audio data was observed. Then; only image, only audio and dual combinations of all data subsets were evaluated. In the end, classification accuracy of fused data including all sensors was compared to the rest of the results. The proposed fusion of all features provides a classification accuracy of 98.2% in our experiments when combined with a Bagged Trees classifier.
YANSIMALI ODA İÇERİSİNE BİR KARIŞTIRICI EKLENMESİNİN VE KARIŞTIRICI KONUMUNUN ELEKTRİK ALAN DÜZGÜNLÜĞÜNE ETKİSİNİN İNCELENMESİ
Authors: URUL Bülent , TÜTÜNCÜ Bilal , HELHEL Selçuk
Published: March 2019

Yansımalı odalar görece çok ucuza gerçeklenebilmeleri nedeni ile son yıllarda elektromanyetik uyumluluk testleri için kullanılan yeni ve etkili bir test ortamıdır. Ön uyumluluk test aşamalarında (sonuca ilişkin yüksek yaklaşıklıkta cevap vermeleri nedeni ile) tam yansımasız test ortamları için bir alternatif olarak görülmektedir. Yansımalı oda test ortamları, çalışma hacimlerinin büyüklüğüne rağmen tam yansımasız odalara göre çok daha ucuz kurulum maliyetine sahiptir. Bu çalışmada, elektromanyetik benzetim programı yardımıyla gerçek boyutlarda bir yansımalı oda tasarlanmıştır. Daha sonra tasarlanan bu yansımalı oda içerisine karıştırıcı eklenerek bu karıştırıcının ve karıştırıcının oda içerisindeki konumunun alan düzgünlüğüne olan etkisi incelenmiştir. Gözlemlenen sonuçlara göre oda içerisine karıştırıcı eklenmesinin elektrik alanların standart sapmasına yani elektrik alan düzgünlüğüne olan etkisi ortalama 1 dB’dir. Bunun yanında oda içerisindeki karıştırıcı konumun elektrik alan düzgünlüğüne oldukça az bir etkisi olmasına rağmen Uluslararası Elektroteknik Komisyon standartının(IEC 61000-4-21) önerdiği limitleri elde etmek için karıştırıcı konumun belirlenmesinin önemli ölçüde bir etkiye sahip olduğu gözlemlenmiştir.
FARKLI METODLARLA ELDE EDİLEN NANO GÜMÜŞ PARÇACIKLI/BAKTERİYEL SELÜLOZ (AG/BS) NANOKOMPOZITIN ANTİBAKTERİYEL ÖZELLİĞİNİN BELİRLENMESİ
Authors: SOFU Aytül
Published: March 2019

Nano kompozit yapısı ağsı bir oluşum gösteren bakteriyel selüloz (BS), son zamanlarda biyomedikal alanlarda kullanımı artmış hafif, toksik olmayan su tutma kapasitesi oldukça yüksek, biyouyumlu ve ekolojik olması yönüyle oldukça avantajlı bir materyaldir. Bu çalışma, sirke bakterileri tarafından üretilen BS nin gümüşü nanoboyutta absorbe ederek antibakteriyel bir etki göstermesine örnek teşkil etmektedir. İki farklı metodla oluşturulan gümüş/bakteriyel selüloz Ag/BS nanokompozit agar difüzyon yöntemi ile antibakteriyellik testleri ve su tutma kapasiteleri belirlenmiştir. Antibakteriyellik testi patojen özellik gösteren 4 farklı bakteri kültürü ile yapılmıştır. Ag/BS nanokompozit tüm patojen bakterilere karşı antibakteriyel inhibisyon zon oluşumu göstermiş, özellikle E. coli bakterisine karşı daha kuvvetli etki göstermiştir.
ADSORPTION ISOTHERMS OF KIWIFRUIT DRIED BY DIFFERENT DRYING METHODS
Authors: KIZMAZ Ayşe , ALTIOK Duygu , BARUTÇU MAZI Işıl
Published: March 2019

The aim of this study was to
determine the moisture adsorption isotherms of kiwifruit dried by hot air,
vacuum and freeze drying methods. Equilibrium moisture contents (EMC) of dried
kiwifruits were obtained by using the standard gravimetric method at two different
temperatures (25 and 45°C) within a range of water activities from 0.112 to
0.936. The adsorption isotherms of dried kiwifruits decreased with increasing
temperature and exhibited type III behavior. Six different isotherm equations
(GAB (Guggenheim-Anderson-de Boer), BET (Brunauer-Emmett-Teller), Oswin,
Henderson, Halsey and Peleg) were employed to describe the experimental adsorption
isotherm data. Adsorption data obtained at both 25 and 45°C for vacuum dried
samples and data obtained at 45°C for hot air and freeze dried samples were
best represented by Peleg equation. For the samples dried by hot air and freeze
drying, GAB equation gave the best description of the experimental data
obtained at 25°C.
Comparison between porous tantalum metal implants and autograft in anterior cervical discectomy and fusion: a meta-analysis
Authors: Li Na , Hu Wen-qing , Xin Wen-qiang , Li Qi-feng , Tian Peng
Published: March 2019

Aim:
The objective of this study was to systematically compare the safety and efficacy of porous tantalum metal (TM) implants and autograft in single-level anterior cervical discectomy and fusion.
Methods:
Potential academic articles were acquired from the Cochrane Library, Medline, PubMed, Embase, Science Direct and other databases. The time range used was from the inception of the electronic databases to March 2018. Gray studies were identified from the references of included literature reports. STATA version 11.0 (Stata Corporation, TX, USA) was used to analyze the pooled data.
Results:
Four randomized, controlled trials (RCTs) were identified according to the retrieval process. There were significant differences in operation time (mean difference [MD]: -28.846, 95% confidence interval [CI: -47.087, -10.604], p = 0.002) and satisfaction rate (odds ratio [OR]: 2.196, 95% CI: [1.061–4. 546]; p = 0.034). However, no significant difference was detected in blood loss (MD: -73.606, 95% CI: [-217.720, 70.509], p = 0.317), hospital stay (MD: -0.512, 95% CI [-1.082, 0.058]; p = 0.079), fusion rate (OR: 0.497, 95% CI [0.079, 3.115]; p = 0.455), visual analog scale (MD: -0.310, 95% CI [-0.433, -0.186]; p < 0.001) or complication rate (risk difference [RD]: -0.140, 95% CI: [-0.378, 0.099]; p = 0.251).
Conclusion:
Porous TM implants are equally as effective and safe as autograft in anterior cervical discectomy and fusion processes. In addition, porous TM implants could reduce operation time and improve clinical satisfaction significantly.
FINANCIAL PERFORMANCE OF SHARIA BANKS BEFORE AND AFTER SPIN-OFF
Authors: Naomi Prima
Published: March 2019

This research aimed at identifying whether Bank Umum Syariah (BUS), as the result of spin-off of Unit Usaha Syariah  (UUS), has better performance compared to the period when they were still in the form of UUS. There are 4 out of 5 BUSes as a result of spin-off us as samples. The results indicate that: 1) the spin-off of UUS to become BUS has successfully increased the market share of each BUS; 2) there is no significant difference in the profitability before and after spin-off in most sample; 3) no significant difference related to the operational efficiency.
No Individual Creativity, No Organizational Innovation
Authors: Hulpke John Francis
Published: March 2019

Innovation is important. Creativity is a necessary prelude to innovation. Academics and professionals need to pay more attention to creativity. One reason for inadequate innovation is the lack of attention to creativity. A related issue appears to be systematic stifling of creativity. Business schools should be preparing tomorrow’s leaders for an exciting, stimulating, challenging and changing future. Too often universities train people to approach questions by looking at what has been done in the past. One confounding issue has to do with possible lack of clarity about terminology. Some confuse the two terms “innovation” and “creativity.” They are not the same although some use the terms interchangeably. This leads to possible confusion regarding “levels of analysis.” Creativity is an individual level factor. The term innovation is best applied at an organizational level of analysis. To foster and encourage organizational innovation, a recommended first step would be to encourage individual creativity.
Uso de ultrasonido en fístulas arteriovenosas de difícil canulación en hemodiálisis
Authors: Villanueva Bendek Ignacio , Ruiz Mauricio , Vega Lia
Published: March 2019

El acceso vascular en hemodiálisis constituye uno de los pilares de éxito del programa. Por tanto, los esfuerzos se deben encaminar a lograr en primera instancia el mayor número de accesos vasculares tipo fístulas Arterio-venosas, y en segundo lugar a disminuir las complicaciones relacionadas con la canulación del acceso para preservar funcionalmente el mismo.
Calcifilaxis en terapia de sustitución renal
Authors: Mendoza Panta Diego Alexander , Huertas Garzón Jorge Washington , Osorio Chuquitarco Washington Xavier
Published: March 2019

La calcifilaxis es una de las complicaciones menos comunes de la enfermedad renal crónica avanzada, sobretodo en terapia de sustitución renal, se desconoce la fisiopatología exacta de aparición, pero se cree, que es por una alteración en el metabolismo óseomineral.
Carga, acceso y disparidades en enfermedad renal
Authors: Crews Deidra C. , Bello Aminu K. , Saadi Gamal;
Published: March 2019

La enfermedad renal es un problema global de salud pública que afecta a más de 750 millones de personas alrededor de todo el mundo. La carga de la enfermedad renal varía sustancialmente a lo largo del planeta, al igual que su detección y tratamiento. A pesar de que la magnitud y el impacto de la enfermedad renal está mejor definida en los países desarrollados, evidencia reciente sugiere que los países en desarrollo tienen una carga de la enfermedad similar o incluso mayor que los primeros.
ANALYSIS OF THE READINESS TOWARDS THE IMPLEMENTATION OF ISO STANDARD 9001: 2015 IN THE COMPANY OF HEAVY EQUIPMENT
Authors: Suhendris Suhendris , Saroso Dana Santoso
Published: March 2019

Heavy equipment market in Indonesia is very large, the opportunity to increase heavy equipment business is wide open, and all competitors provide the best products and services for their customers. For this reason, companies need to develop an international standard system. The system is known as Quality Management System (QMS) and developed in ISO 9001: 2015 standard certification. ISO 9001 is a standard that contains the requirements of the Quality Management System issued by the International Organization for Standardization (IOS). Companies that become the object of research is heavy equipment company engaged in the sale of heavy equipment and after-sales service. The problem that is going on in this company is that there is a lot of down payment for the purchase of units and spare parts that cannot be billed due to the documents that are related to the purchase process, many of which are non-existent and also missing, besides that there are also many complaints regarding the availability of spare parts and service, this is one of the indirect impacts of not implementing QMS ISO 9001: 2015. The research objective is to evaluate the current condition of the Heavy Equipment Company and assess the readiness of the Company in meeting ISO 9001: 2015 standards. The method used is Gap Analysis requirements of ISO 9001: 2015. Calculation on Gap Analysis uses a checklist made based on the requirements of ISO 9001: 2015, and the results will show how much the readiness of the Heavy Equipment Company meets the ISO 9001: 2015 standard.