bluuebunny/crossref_metadata_2025 huggingface dataset:
The Public and Medical Staff Understanding of COVID-19: A Large Sample, Multi-Center, Cross-Sectional Study
Authors: Wu Yi-Bo , Liu Si-Tong , He Xi-Zhe , Yu Chun , Huang Xiang-Dong , Shi Lin-Ling , Tang Qin
Published: September 2020

Objective: To understand the cognition condition of the public and medical staff of COVID-19. Method: A cross-sectional study was carried out by giving out online questionnaires. Results: The scores of medical staff and the public are 92.47 ± 5.76 and 89.53 ± 8.27, respectively, the differences between them are statistically significant (p = 0.000). The accuracies of medical staff and the public in etiological characteristics, clinical characteristics, disease definition, disease prevention and treatment and misunderstanding are 91.27 ± 11.60%, 86.73 ± 15.74%, 86.73 ± 15.74%, 98.63 ± 4.23%, 87.84 ± 13.53% and 87.52 ± 14.64%, 84.09 ± 17.49%, 93.63 ± 10.20%, 97.30 ± 8.10%, and 87.43 ± 13.51%, respectively. Residence, region and education background have significant impacts on the scores of medical staff, gender, residence, age, region and education background have significant effects on the scores of the public. Conclusions: The cognition of medical staff and the public of COVID-19 is favorable, and the former is better than the latter, both of them have good grasps of disease prevention and treatment, while have poor grasps of clinical characteristics and misunderstanding of the virus. The demographic characteristics have some effects on the cognition condition of the subjects.
From Pan-African Transpression to Cadomian Transtension at the West African Margin: New U–Pb zircon Ages from the Eastern Saghro Inlier (Anti-Atlas, Morocco)
Authors: Errami Ezzoura , Linnemann Ulf , Hofmann Mandy , Gärtner Andreas , Zieger Johannes , Gärtner Jessica , Mende Katja , El Kabouri Jamal , Gasquet Dominique , Ennih Nasser
Published: September 2020

New U–Pb zircon ages from the Eastern Saghro massif in the Anti-Atlas of Morocco demonstrate a link between Pan-African transpressive collision at
c.
600 Ma and transtension caused by the onset of Cadomian subduction and arc development from
c.
570 Ma onwards. We present new U–Pb laser ablation inductively coupled plasma mass spectrometry ages of detrital and magmatic zircon from the Saghro, M'Gouna, and Ouarzazate Groups. The siliciclastic deposits of the Saghro Group were deposited in a back-arc setting developed on stretched continental crust of the West African margin. Collision with the Atlas–Meseta domain led to the closure of the back-arc basin before 600 Ma. Time of exhumation and surface exposure of the newly formed Pan-African basement is bracketed to
c.
30 Ma owing to the maximum depositional age of 571 ± 4 Ma of the overlying M'Gouna Group. The U–Pb age of 567 ± 4 Ma for the lowermost ignimbrite of the Ouarzazate Group limits the time for the deposition of the M'Gouna Group to less than 4 Ma. The Pan-African orogeny was finished at
c.
600 Ma whereas the onset of transtension related to Cadomian back-arc formation was very much younger from
c.
570 Ma onwards.
Axon Regeneration in the Mammalian Optic Nerve
Authors: Williams Philip R. , Benowitz Larry I. , Goldberg Jeffrey L. , He Zhigang
Published: September 2020

The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual functional defects observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressive optic neuropathies such as from optic glioma. By using optic nerve crush injury models, recent studies have revealed the cellular and molecular logic behind the regenerative failure of injured RGC axons in adult mammals and suggested several strategies with translational potential. This review summarizes these findings and discusses challenges for developing clinically applicable neural repair strategies.
Microglia Activation and Inflammation During the Death of Mammalian Photoreceptors
Authors: Karlen Sarah J. , Miller Eric B. , Burns Marie E.
Published: September 2020

Photoreceptors are highly specialized sensory neurons with unique metabolic and physiological requirements. These requirements are partially met by Müller glia and cells of the retinal pigment epithelium (RPE), which provide essential metabolites, phagocytose waste, and control the composition of the surrounding microenvironment. A third vital supporting cell type, the retinal microglia, can provide photoreceptors with neurotrophic support or exacerbate neuroinflammation and hasten neuronal cell death. Understanding the physiological requirements for photoreceptor homeostasis and the factors that drive microglia to best promote photoreceptor survival has important implications for the treatment and prevention of blinding degenerative diseases like retinitis pigmentosa and age-related macular degeneration.
Minimally Invasive Glaucoma Surgery: A Critical Appraisal of the Literature
Authors: Mathew David J. , Buys Yvonne M.
Published: September 2020

Micro- or minimally invasive glaucoma surgeries (MIGS) have been the latest addition to the glaucoma surgical treatment paradigm. This term refers not to a single surgery, but rather to a group of distinct procedures and devices that aim to decrease intraocular pressure. Broadly, MIGS can be categorized into surgeries that increase the trabecular outflow [Trabectome, iStent (first and second generations), Hydrus microstent, Kahook Dual Blade and gonioscopy-assisted transluminal trabeculotomy], surgeries that increase suprachoroidal outflow (Cypass microstent and iStent Supra), and conjunctival bleb-forming procedures (Xen gel stent and InnFocus microshunt). Compared to traditional glaucoma surgeries, such as trabeculectomy and glaucoma drainage device implantation (Ahmed, Baerveldt, and Molteno valves), MIGS are touted to have less severe complications and shorter surgical time. MIGS represent an evolving field, and the efficacy and complications of each procedure should be considered independently, giving more importance to high-quality and longer-term studies.
Effects of exercise on thoracic blood volumes, lung fluid accumulation, and pulmonary diffusing capacity in heart failure with preserved ejection fraction
Authors: Fermoyle Caitlin C. , Stewart Glenn M. , Borlaug Barry A. , Johnson Bruce D.
Published: September 2020

Patients with heart failure with preserved ejection fraction (HFpEF) experience symptoms of exertional dyspnea that may be related to lung fluid accumulation during exercise. A computed tomography (CT)-based method was used to measure exercise-induced changes in extravascular lung fluid content and thoracic blood volumes and to determine the effect of lung fluid on lung diffusing capacity for carbon monoxide (DLCO) in stable subjects with HFpEF and healthy controls. Nine subjects with HFpEF (age = 68 ± 8 yr; body mass index = 32.1 ± 2.6 kg/m2) and eight healthy controls (62 ± 9 yr, 23.8 ± 2.4 kg/m2) performed triplicate rebreathe DLCO/DLNO (lung diffusing capacity for nitric oxide) tests in a supine position at rest and duplicate measurements during two 5-min submaximal exercise stages (15W and 35W) and recovery. Subjects subsequently performed a 5-min exercise bout (35W) inside a CT scanner, and extravascular lung fluid content and thoracic blood volumes were quantified at rest and immediately following exercise from thoracic and contrast perfusion scans, respectively. Subjects with HFpEF had a higher lung fluid content at rest compared with controls (means ± SD, HFpEF: 14.4 ± 1.7%, control: 12.8 ± 1.7%, P = 0.043) and a higher lung fluid content following exercise (15.2 ± 2.0% vs. 12.6 ± 1.5%, P = 0.009). Higher lung fluid content was associated with a lower DLCO and alveolar-capillary membrane conductance (Dm) in subjects with HFpEF (DLCO: R = −0.57, P = 0.022, Dm: R = −0.61, P = 0.012) but not in controls. Pulmonary blood volume was not altered by exercise and was similar between groups. Submaximal exercise elicited a greater accumulation of lung fluid in subjects with HFpEF compared with in controls, and lung fluid content was negatively correlated with lung diffusing capacity and alveolar-capillary membrane conductance in subjects with HFpEF.
On Using XMC R-CNN Model for Contraband Detection within X-Ray Baggage Security Images
Authors: Zhang Yong , Kong Weiwu , Li Dong , Liu Xudong
Published: September 2020

We present an X-ray material classifier region-based convolutional neural network (XMC R-CNN) model for detecting the typical guns and the typical knives in X-ray baggage images. The XMC R-CNN model is used to solve the problem of contraband detection in overlapped X-ray baggage images by the X-ray material classifier algorithm and the organic stripping and inorganic stripping algorithm, and better detection rate and the miss rate are achieved. The detection rates of guns and knives are 96.5% and 95.8%, and the miss rates of guns and knives are 2.2% and 4.2%. The contraband detection technology based on the XMC R-CNN model is applied to X-ray baggage images of security inspection. According to user needs, the safe X-ray baggage images can be automatically filtered in some specific fields, which reduces the number of X-ray baggage images that security inspectors need to screen. The efficiency of security inspection is improved, and the labor intensity of security inspection is reduced. In addition, the security inspector can screen X-ray baggage images according to the boxes of automatic detection, which can improve the effect of security inspection.
Prevalence and Factors Influencing Eye Injuries among Welders in Accra, Ghana
Authors: Kwaku Tetteh Karl Kafui , Owusu Richard , Axame Wisdom Kudzo
Published: September 2020

Background. Eye injuries are one of the most common work-related injuries among certain occupations, including welders. The aim of this study was to determine the prevalence and factors influencing eye injuries among welders in Accra, Ghana. Methods. In a cross-sectional study, we recruited 382 welders in Accra from two welding sites. Systematic sampling was used to select participants. A pretested semistructured questionnaire was used to collect demographic information, history of eye injuries, ownership, and use of eye protective equipment and workplace characteristics. Bivariate and multivariate logistic regressions at 5% level of significance were used to determine factors influencing eye injuries. Data were entered into Microsoft excel and exported to Stata 16/MP for analysis. Results. We found 59.7% of welders engaged in electric/arc welding and 40.3% in gas welding. Overall prevalence of eye injuries was 47.9%, higher among electric/arc welders (73.7%) compared to gas welders (9.7%). Factors associated with eye injuries were engaging in gas welding [AOR: 0.08, 95% CI: 0.04–0.16], higher monthly income [AOR = 5.26; 95% CI: 1.72–16.09], nonuse of eye PPE while working [AOR = 1.86; 95% CI: 1.02–3.43], and no training on the use of eye personal protective equipment [AOR = 2.17; 95% CI: 1.07–4.38]. Conclusion. There is high prevalence of welding-related eye injuries among electric welders. Gas welding, high monthly income, nonuse of eye protective equipment, and inadequate training on the use of eye protective equipment were significantly associated with eye injuries. Health policies should be implemented to ensure all welders use eye personal protective equipment.
Prediction for Chaotic Time Series-Based AE-CNN and Transfer Learning
Authors: Xin Baogui , Peng Wei
Published: September 2020

It has been a hot and challenging topic to predict the chaotic time series in the medium-to-long term. We combine autoencoders and convolutional neural networks (AE-CNN) to capture the intrinsic certainty of chaotic time series. We utilize the transfer learning (TL) theory to improve the prediction performance in medium-to-long term. Thus, we develop a prediction scheme for chaotic time series-based AE-CNN and TL named AE-CNN-TL. Our experimental results show that the proposed AE-CNN-TL has much better prediction performance than any one of the following: AE-CNN, ARMA, and LSTM.
Neonatal Hypothermia and Associated Factors among Newborns Admitted in the Neonatal Intensive Care Unit of Dessie Referral Hospital, Amhara Region, Northeast Ethiopia
Authors: Yitayew Yibeltal Asmamaw , Aitaye Endashaw Belayhun , Lechissa Helina Wondimu , Gebeyehu Lubaba Oumer
Published: September 2020

Introduction. Neonatal hypothermia is the reduction in the body temperature of the newborn (less than 36.5°C). It is a global problem in neonates born both at hospitals and homes, but it showed a higher prevalence in developing countries (>90%). Although hypothermia is rarely a direct cause of death, it contributes to a substantial proportion of neonatal mortality globally. Objective. To assess neonatal hypothermia and associated factors among newborns admitted in the NICU of Dessie Referral Hospital. Methods and Materials. An institution-based cross-sectional study was conducted from March 15 to May 30, 2018. The data was collected from the mother and the chart of the newborn using a semistructured questionnaire. Data were cleaned, coded, and entered in EPI-info version 7.1.2.0 then exported to Statistical Package for Social Sciences (SPSS) version 20 software for analysis. Descriptive statistics were used to summarize the data. Bivariate and multivariate logistic regression and crude and adjusted odds ratio with their 95% confidence interval were computed. Finally, p value < 0.05 was used to identify variables that had a significant association with neonatal hypothermia. Result. The proportion of neonatal hypothermia in the study area was 66.8%. Preterm delivery (AOR=2.6, 95% CI: 1.1, 6.2), no skin-to-skin contact within 1 hour of delivery (AOR=3.0, 95% CI: 1.3, 7.8), delivered at night time (AOR=2.0, 95% CI: 1.02, 4.0), and neonates who had resuscitation (AOR=2.9, 95% CI: 1.1, 7.2) showed significant association with neonatal hypothermia. Conclusion. In this study, the proportion of hypothermia was high. Preterm delivery, no skin-to-skin contact within 1 hour, night-time delivery, and having resuscitation were significantly associated with neonatal hypothermia. Therefore, special attention is needed for the thermal care of preterm neonates and neonates delivered at night time. Furthermore, there should be strict adherence to cost-effective thermal care recommendations like warm resuscitation and skin-to-skin contact.
Mobile Positioning Techniques and Systems: A Comprehensive Review
Authors: Ramtohul Arvind , Khedo Kavi Kumar
Published: September 2020

The recent developments in mobile positioning technologies and the increasing demands of ubiquitous computing have significantly contributed to sophisticated positioning applications and services. Position information represents a core element in the human-centred activities, assisting in visualising complex environments effectively and providing a representational coordinate for localisation, tracking, and navigation purposes. The emergence of smartphones has accelerated the development of cutting-edge positioning-based systems since they are contained to have more processing, memory, and battery power. Similarly, mobile devices are now equipped with new sensory capabilities, wireless communications, and localisation technologies. This has quadrupled towards new advances on positioning techniques, enhancing the existing ones and brought more value to positioning-based systems. Research studies in positioning techniques have progressed in different directions, and no work has categorised and assessed the various advancements in this area. Accuracy and precision are the two challenging aspects that are crucial to the proper functioning of a positioning system. In practice, there is not a single positioning technique that could be appropriate for different situations. Most of the survey papers have focussed on carrying out their review on conventional positioning techniques. The common positioning technique uses simple technologies and is applied to a single type of environment. Hybrid techniques are the next generation of positioning technique that is supporting the real and com plex environment. This paper presents a comprehensive review on the mobile positioning techniques and systems. A total of 21 positioning systems published between the years 2012 and 2018 in the top 5 most popular indexed databases are reviewed. The positioning techniques are identified and streamlined through a methodical process, and the selected ones are reviewed using derived parameters. This paper provides a significant review of the current state of the mobile positioning techniques and outlines the research issues that require more investigation.
A Deep Learning Approach for a Source Code Detection Model Using Self-Attention
Authors: Meng Yao , Liu Long
Published: September 2020

With the development of deep learning, many approaches based on neural networks are proposed for code clone. In this paper, we propose a novel source code detection model At-biLSTM based on a bidirectional LSTM network with a self-attention layer. At-biLSTM is composed of a representation model and a discriminative model. The representation model firstly transforms the source code into an abstract syntactic tree and splits it into a sequence of statement trees; then, it encodes each of the statement trees with a deep-first traversal algorithm. Finally, the representation model encodes the sequence of statement vectors via a bidirectional LSTM network, which is a classical deep learning framework, with a self-attention layer and outputs a vector representing the given source code. The discriminative model identifies the code clone depending on the vectors generated by the presentation model. Our proposed model retains both the syntactics and semantics of the source code in the process of encoding, and the self-attention algorithm makes the classifier concentrate on the effect of key statements and improves the classification performance. The contrast experiments on the benchmarks OJClone and BigCloneBench indicate that At-LSTM is effective and outperforms the state-of-art approaches in source code clone detection.
The Design of Compact Robotic-Assisted Needle Position System with MPC-Based Remote Control
Authors: Guo Jing , Liu Yi , Wang Jin , Zeng Chao , Huang Jie , Liu Chao
Published: September 2020

This article introduces the design and control performance of a lightweight, flexible, 4-degree-of-freedom (DOF) parallel robot for percutaneous biopsy guided by computed tomography (CT). At present, the CT guidance method allows surgeons to quickly locate the lesion area; however, it is necessary to manually adjust the position of the puncture needle for insertion. In this paper, a three-dimensional assisted method is used to infer the control input required to reach the target point through the kinematic model of the robot. A Kalman filter is designed to estimate model parameters and obtain a more accurate model. To further improve the control performance of the robot system, a model-based control method—the model predictive control (MPC) controller—is used to increase the accuracy of the needle position in the developed robot system. In this way, medical efficiency is improved while reducing the burden on the surgeon.
Utility of the Rose Bengal Test as a Point-of-Care Test for Human Brucellosis in Endemic African Settings: A Systematic Review
Authors: Ekiri Abel B. , Kilonzo Christopher , Bird Brian H. , VanWormer Elizabeth , Wolking David J. , Smith Woutrina A. , Masanja Honorati , Kazwala Rudovick R. , Mazet Jonna A.K.
Published: September 2020

In endemic African areas, such as Tanzania, Brucella spp. cause human febrile illnesses, which often go unrecognized and misdiagnosed, resulting in delayed diagnosis, underdiagnosis, and underreporting. Although rapid and affordable point-of-care tests, such as the Rose Bengal test (RBT), are available, acceptance and adoption of these tests at the national level are hindered by a lack of local diagnostic performance data. To address this need, evidence on the diagnostic performance of RBT as a human brucellosis point-of-care test was reviewed. The review was initially focused on studies conducted in Tanzania but was later extended to worldwide because few relevant studies from Tanzania were identified. Databases including Web of Science, Embase, MEDLINE, and World Health Organization Global Index Medicus were searched for studies assessing the diagnostic performance of RBT (sensitivity and specificity) for detection of human brucellosis, in comparison to the reference standard culture. Sixteen eligible studies were identified and reviewed following screening. The diagnostic sensitivity (DSe) and specificity (DSp) of RBT compared to culture as the gold standard were 87.5% and 100%, respectively, in studies that used suitable “true positive” and “true negative” patient comparison groups and were considered to be of high scientific quality. Diagnostic DSe and DSp of RBT compared to culture in studies that also used suitable “true positive” and “true negative” patient comparison groups but were considered to be of moderate scientific quality varied from 92.5% to 100% and 94.3 to 99.9%, respectively. The good diagnostic performance of RBT combined with its simplicity, quickness, and affordability makes RBT an ideal (or close to) stand-alone point-of-care test for early clinical diagnosis and management of human brucellosis and nonmalarial fevers in small and understaffed health facilities and laboratories in endemic areas in Africa and elsewhere.
NECTAR-An Agent-Based Dynamic Task Allocation Algorithm in the UAV Swarm
Authors: Chen Chao , Bao Weidong , Men Tong , Zhu Xiaomin , Wang Ji , Wang Rui
Published: September 2020

The advancement of UAV technology makes the use of UAVs more and more widespread, and the swarm is the main mode of UAV applications owing to its robustness and adaptability. Meanwhile, task allocation plays an essential role in a swarm to obtain overall high performance and unleash the potential of each UAVs owing to the complexity of the large-scale swarm. In this paper, we pay attention to the real-time allocation problem of dynamic tasks. We design models for the task assigning problem to construct the constraints model and assigning objectives. In addition, we introduce a novel agent-based allocating mechanism based on the auction process, including the design for three kinds of agents and the cooperation mechanism among different agents. Moreover, we proposed a new algorithm to calculate the bidding values of UAVs, by which the messages passed between UAVs can be reduced. On the basis of the assigning mechanism, we put up with a novel agent-based real-time task allocation algorithm named NECTAR for dynamic tasks in the UAV swarm. Furthermore, we conduct extensive experiments to evaluate the performance of our NECTAR, and the results indicate that NECTAR is able to solve the real-time task allocation for dynamic tasks and achieve high performance of the UAV swarm.
Fractal Characteristics, Multiple Bubbles, and Jump Anomalies in the Chinese Stock Market
Authors: Meng Sun , Fang Hairui , Yu Dongping
Published: September 2020

To consider the jump problem of the Chinese stock market, this paper takes the CSI 300 Index from April 2005 to November 2015 as the research object, uses the rescaled range analysis (R/S analysis) method to examine the fractal characteristics of the Chinese stock market in the past ten years, and deduces the possibility of multiple bubbles in the Chinese stock market. Based on this, combined with the log-periodic power law (LPPL) model, the stock market bubbles are identified in different periods. The results show that China’s stock market has some anomalies in terms of positive bubbles, negative bubbles, and reverse bubbles, as well as the cross occurrence of reverse-negative bubbles. Besides, through a comparison with the major foreign stock markets, it is found that the fluctuation range of the Chinese stock market is much larger than that of the Dow Jones Industrial Average and the FTSE 100 indices in the same period and there are also more types of multibubbles, which is a connotative anomaly that makes the Chinese stock market different from other major stock markets. Furthermore, the bubble phenomenon in the Chinese stock market during the periods of 2005/4–2007/10 and 2015/6–2015/11 is studied, and it is found that there is a jump anomaly in the Chinese stock market. Finally, based on the above empirical analysis and the current state of the stock market, this paper provides some suggestions for improving the mechanism of the Chinese stock market.
An Adaptive Model Order Reduction Method Based on the Damage Evolution for Nonlinear Seismic Analysis
Authors: Wang Jian , Fang Ming , Li Hui
Published: September 2020

Nonlinear seismic analysis, an approach to evaluate the seismic performance of a structure, is facing the challenge of computational efficiency for large‐scale and high‐fidelity simulation. This paper proposes an adaptive model order reduction (MOR) method based on the damage evolution among the overall structure to alleviate the computational burden. The damage state of each component during seismic loadings is distinguished as the initial‐elastic phase, the plastic‐damage phase, and the residual‐elastic phase. In order to exploit the potential of model order reduction based on the damage evolution, a duration spectrum analysis is utilized to evaluate the characteristics of the residual‐elastic phase for SDOF systems with bilinear hysteretic behaviour. Thus, an adaptive MOR method has been proposed to handle the nonlinear dynamic analysis of structures during different damage evolution phases. The overall structure is adaptively partitioned into linear substructures and nonlinear substructures on the basis of the time‐varying damage distribution. The model order of linear substructures is reduced using the initial stiffness‐based vibration modes, while nonlinear substructures that keep in the residual‐elastic phase are reduced using the tangent‐stiffness‐based vibration modes. The residual displacements of nonlinear substructures are treated as the initial deformation during the residual‐elastic phase. Compared with the traditional time step integration method, the proposed adaptive MOR method is able to increase the computational efficiency as yielding comparative results.
A Study of the Laws of Abnormal Gas Emissions and the Stability Controls for Coal Mine Walls in Deeply Buried High‐Gas Coal Seams
Authors: Yuan Anying , Hu Hao , Yuan Qiupeng
Published: September 2020

At the present time, it is considered to be of major significance to study the gas emission law and stability controls of coal bodies in deeply buried high‐gas coal seams. For this reason, in view of the specific problems of gas emissions caused by unstable rib spalling in coal mine walls, comprehensive research methods were adopted in this study, in order to conduct an in‐depth examination of micropore structure parameters, gas desorption, diffusion laws, and coal stability levels. The results showed that the development degree of the pores above the micropores, as well as the small pores in soft coal seams, was better than those observed in hard coal seams. In addition, the gas outburst phenomenon was found to have more easily formed in the soft coal seams. The coal body of the No. 6 coal seam in the Xieqiao Coal Mine not only provided the conditions for gas adsorption but also provided dominant channels for gas diffusion and migration. The abnormal gas emissions of the No. 6 coal seam were jointly caused by the relatively developed pores above the small holes in the coal body, rib spalling of coal mine walls, and so on. The research results also revealed the evolution law of mechanical characteristics of the No. 6 coal seam under different water content conditions. It was found that the strength levels of the No. 6 coal seam first increased and then decreased with the increase in water content, and the water content level at the maximum strength of the coal seam was determined to be 7.09%. This study put forward a method which combined the water injection technology of long‐term static pressure water injections in deep coal mining holes and real‐time dynamic pressure water injections in shallower holes. Field experiments were successfully carried out.
Long Noncoding RNA HOTAIR Promotes Epithelial-Mesenchymal Transition and Is a Suitable Target to Inhibit Peritoneal Dissemination in Human Scirrhous Gastric Cancers
Authors: Takei Yoshifumi , Hara Toshifumi , Suzuki Akiko , Mihara Keichiro , Yanagihara Kazuyoshi
Published: September 2020

Objectives: Scirrhous gastric cancer, which accounts for approximately 10% of all gastric cancers, often disseminates to the peritoneum, leading to intractable cases with poor prognosis. There is an urgent need for new treatment approaches for this difficult cancer. Methods: We previously established an original cell line, HSC-60, from a scirrhous gastric cancer patient and isolated a peritoneal-metastatic cell line, 60As6, in nude mice following orthotopic inoculations. In the present study, we focused on the expression of long noncoding ribonucleic acid (RNA) (lncRNA) in the cell lines and investigated the mechanism on peritoneal dissemination. Results: We demonstrated that an lncRNA, HOX transcript antisense RNA (HOTAIR), is expressed significantly more highly in 60As6 than HSC-60 cells. Then, using both HOTAIR knockdown and overexpression experiments, we showed that high-level expression of HOTAIR promotes epithelial-mesenchymal transition (EMT) in 60As6 cells. By luciferase assay, we found that HOTAIR directly targets and binds to miR-217, and that miR-217 directly binds to Zinc finger E-box-binding homeobox 1 (ZEB1). The knockdown of HOTAIR in 60As6 cells significantly reduced the invasion activity and peritoneal dissemination – and significantly prolonged the survival – in the orthotopic tumor mouse model. Conclusion: An EMT-associated pathway (the HOTAIR-miR-217-ZEB1 axis) appears to inhibit peritoneal dissemination and could lead to a novel therapeutic strategy against scirrhous gastric cancer in humans.
Eye Preference for Emotional Stimuli in Sichuan Snub-Nosed Monkeys
Authors: Zhao Dapeng , Wang Yuan , Li Baoguo
Published: September 2020

This study presents the first evidence of effects of applying both positive and negative stimuli simultaneously on visual laterality in Old World monkeys. Thirteen captive individuals of Sichuan snub-nosed monkeys (Rhinopithecus roxellana) were chosen as focal subjects in the monocular box task. In total, 4 emotional categories (the preferred, the novel, the neutral, and the fearful) of visual stimuli were applied, and eye preference was recorded when individuals looked at each stimulus through an observation hole in the box. We found evidence of visual laterality at the individual level, but not at the group level for each stimulus. For the preferred stimulus, 9 individuals showed significant right-eye preference while 4 individuals showed significant left-eye preference. For the other 3 stimuli, 7 individuals displayed significant right-eye preference while 6 individuals displayed significant left-eye preference. Totally, 11 of 13 individuals showed consistency in the visual laterality direction (7 right-eye preference and 4 left-eye preference) across the 4 stimuli. The remaining 2 individuals displayed right-eye preference for the preferred stimulus while they showed left-eye preference for the other 3 stimuli. There was no significant difference among various stimuli regarding the direction of visual laterality. However, there was a significant difference in the strength of visual laterality among various stimulus categories. The strength of visual laterality for the preferred stimulus was significantly lower than that for the other 3 stimuli. The strength of visual laterality for the fearful stimulus was significantly higher than that for the novel stimulus and the neutral stimulus. Furthermore, the looking duration for the preferred stimulus was significantly higher than that for the other 3 stimuli. The looking duration for the novel stimulus was significantly higher than that for the neutral stimulus and the fearful stimulus. The looking duration for the neutral stimulus was significantly higher than that for the fearful stimulus. Our findings indicate emotional valence of stimuli significantly influence eye looking duration and the strength of visual laterality but not for the direction of visual laterality in this species. Taken together, emotional valence of stimuli plays an important role in the eye use of R. roxellana.
A Unified Concept of Acne in the PAPA Spectrum Disorders
Authors: Maitrepierre Flavie , Marzano Angelo Valerio , Lipsker Dan
Published: September 2020

Background:Acne is a common condition. Sometimes acne or acne-like features are a part of autoinflammatory diseases such as PAPA spectrum disorders. Our objective wasto determine whether acne in PAPA spectrum disorders has specific phenotypic traits. Summary: This is aliterature review on reported cases of patients with PAPA, PAMI, PASH, PAPASH, PsAPASH, PAC or PASS syndrome. Acne was classified into four categories: moderate, severe, nodulocystic, acne fulminans.One hundred patients were included. Age of onset of acne and topography were the same as in acne vulgaris. Acne’s phenotype was at least severe (including acne fulminans, nodulocystic and severe) in 83% of cases. Genetic mutations or variants with potential pathological significance were reported in 49 patients. The addition of isotretinoin to biotherapies was required to control acne in several patients.
A Unique Case of Recurrent Upper Gastrointestinal Bleeding Caused by Two Metachronous Dieulafoy’s Lesions: The Role of EUS Evaluation
Authors: Brito Mariana , Nunes Gonçalo , Pinto Marques Pedro , Canhoto Manuela , Proença Ana Luísa , Fonseca Jorge
Published: September 2020

Introduction: Dieulafoy’s lesion (DL) is a rare but important cause of acute, severe, life-threatening, and recurrent upper gastrointestinal bleeding (UGIB). It is frequently difficult to diagnose DL with upper GI endoscopy (UGIE), and endoscopic ultrasonography (EUS) may be valuable. There are only 2 reported bleeding cases caused by two synchronous DL but no reported cases of two metachronous DL. Case Report: A 28-year-old healthy male presented with acute severe UGIB. UGIE was inconclusive. Systematic EUS mapping identified a gastric DL. After several attempts of EUS-guided hemostasis, DL was marked using a through-the-scope clip and the patient underwent successful transcatheter arterial embolization (TAE). Three years later, a new severe UGIB episode was caused by a second gastric DL in a different location, which was identified and marked by EUS and further successfully treated through TAE. The patient maintained follow-up without evidence of further bleeding. Discussion/Conclusion: The authors report a unique case of severe, recurrent UGIB caused by two metachronous gastric DL lesions. The importance of systematic EUS scanning for diagnosis, treatment, and follow-up of DL is emphasized, as well as the potential influence in the outcome of other techniques like angiographic embolization.
A Case of Liver Injury after Exposure to Isopropanol: A Challenging Diagnosis
Authors: Soares Santos Daniela , Nunes Ana Luísa Luísa , Matos Ana Luísa , Lai Ana , Santos Arsénio , Carvalho Armando
Published: September 2020

Drug-induced liver injury is hardly diagnosed, considering not only the wide range of hepatotoxic substances but also the diversity of associated phenotypes and the absence of specific biomarkers. Symptom chronology, drug or toxic exposure, and temporal association help to establish the diagnosis. Exposure to isopropanol has known but rare toxic effects. We report the clinical case of a 33-year-old female hairdresser admitted to the hospital with fatigue, epigastric pain, and jaundice. She presented the following values: aspartate aminotransferase, 485 U/L; alanine transaminase, 908 U/L; ALP, 240 U/L; GGT, 370 U/L; total bilirubin, 3.5 mg/dL; and direct bilirubin, 2.1 mg/dL. Albumin, platelet, and INR values were normal. Structural, infectious, immune, and vascular causes were excluded. Liver biopsy was suggestive of toxic hepatitis. A possible association with ibuprofen intake was considered. The patient resumed professional activity, with fatigue and jaundice relapse, as well as a new liver enzyme increase, despite ibuprofen withdrawal. It was concluded that a new hair product containing isopropanol had recently been introduced. As soon as its professional use was discontinued, there was no recurrence of the symptoms. Given the temporal association between the development of acute hepatitis and the use of an isopropanol-containing product, liver toxicity by exposure to isopropanol was assumed. This substance is metabolized in the liver and toxicity may occur by ingestion, skin exposure, or inhalation, and it is described in cases of occupational or accidental exposure. The treatment is symptomatic and comprises toxic suspension.
Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version
Authors: Yang Bao-Zhu , Wang Liang-Jen , Huang Ming-Chyi , Wang Sheng-Chang , Tsai Meng-Chang , Huang Yu-Chi , Nuñez Yaira Z. , Ng Mei-Hing , Kranzler Henry R. , Gelernter Joel , Chen Chih-Ken
Published: September 2020

The Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) is a polydiagnostic instrument for substance use and psychiatric disorders. We translated the SSADDA English version into Chinese (SSADDA-Chinese) and report here our examination of the diagnostic reliability and validity of DSM-IV substance dependence (SD) diagnoses in a Mandarin-speaking sample in Taiwan. We recruited 125 subjects who underwent an assessment of lifetime SD diagnoses using both the SSADDA-Chinese and the Structured Clinical Interview for DSM-IV, Clinician Version (SCID-Chinese). Thirty-one subjects were retested with the SSADDA-Chinese. Cohen’s κ statistic, which measures chance-corrected agreement, was used to measure the test-retest reliability and concurrent validity of the individual SD diagnoses. There was a high degree of concordance between SD diagnoses made using the SSADDA-Chinese and the SCID-Chinese, including those for dependence on alcohol (κ = 0.83), ketamine (κ = 0.97), methamphetamine (κ = 0.93), and opioids (κ = 0.95). The test-retest reliability of dependence diagnoses for ketamine (κ = 0.95), methamphetamine (κ = 0.80), and opioids (κ = 1.00) obtained using the SSADDA-Chinese was excellent, while that for alcohol dependence (κ = 0.63) and nicotine dependence (κ = 0.65) was good. We conclude that the SSADDA-Chinese is a reliable and valid instrument for the diagnosis of major SD traits in Mandarin-speaking populations.
O Nordeste de Dora e de Tonho: representações cinematográficas sobre o nordeste brasileiro nos filmes “Central do Brasil” e “Abril despedaçado”
Authors: Souza Felipe Cardoso de
Published: September 2020

O presente artigo tem como objetivo analisar as representações construídas sobre o nordeste brasileiro nas obras cinematográficas Central do Brasil (1998) e Abril despedaçado (2001), dirigidos pelo cineasta Walter Salles. Metodologicamente, dialogamos com Hall (1998) para trabalharmos com o conceito de “identidade”; com Chartier (1990) e sua contribuição acerca do conceito de “representações”, considerando o cinema enquanto palco de representações; e com Ellsworth (2011) para trabalharmos com o conceito de “modos de endereçamento”, admitindo que o filme é um produto fabricado e pensado para um determinado público alvo e a partir de determinadas intencionalidades. Os resultados obtidos por meio de nossa análise apontam para reproduções e permanências de uma imagem estereotipada sobre o Nordeste. Portanto, buscamos a partir deste trabalho contribuir com uma narrativa que problematize a construção destes discursos estereotipados sobre esta região brasileira.
“I am not Jasmine; I am Aladdin”: How Youth Challenge Structural Inequity through Critical Hip Hop Literacies
Authors: Leigh Kelly Lauren
Published: September 2020

Previous research on Hip Hop Education has advocated for the inclusion of critical media literacy in schools and for the recognition of Hip Hop music and culture as a central component of young people’s literate and social identities (e.g. Hall, 2017; Kelly, 2020; McArthur, 2016). This article places critical Hip Hop literacy at the intersections of media education, social justice education, and culturally sustaining pedagogies by discussing the role of Hip Hop literature and culture as a form of text that can foster young people’s critical consciousness development in the secondary classroom. Through analysis of data collected in a high school Hip Hop Literature and Culture class, this qualitative case study examines how critical Hip Hop literacy practices can support youth sociopolitical development in racially diverse classrooms and schools. The results of this study reveal the need for schools to support students in identifying, analyzing, and challenging structures of oppression through the development of critical Hip Hop literacies.
Type study of Lachnum japonicum: a new combination proposal with lectotypification

Authors: TOCHIHARA YUKITO , HOSOYA TSUYOSHI
Published: September 2020

Type specimen of Lachnum japonicum Syd. & P. Syd. was discovered in the National Museum of Nature and Science (TNS). Based on the morphological reexamination of it, the species was transferred to the genus Trichopezizella. Trichopezizella japonica comb. nov. was proposed and the specimen was designated as lectotype.
Plant diversity of Khuzestan and dust sources in the southwest of Iran, with a checklist of vascular plants

Authors: DINARVAND MEHRI , JAMZAD ZIBA
Published: September 2020

Khuzestan province covers an area of 64236 square kilometers in the southwest of Iran and the border of Iraq. The area belongs to two regions, Irano-Turanian (IT) in the north and Sahara-Sindian in the south. An area with 349254 ha is the source of dust in Khuz province. We investigated the floristic composition, life-form spectrum and the phytogeography of the area during 2009–2018 by collecting vascular plants to provide an annotated checklist of the plants in Khuz province. In this time about two years focused on the vegetation of the septet areas of the source of dust and dune. Approximately 10,000 vascular plant specimens were collected from 13 types of terrestrial habitats and 15 types of wetlands. A total of 985 species and infraspecific taxa of vascular plants belonging to 487 genera and 93 plant families were recorded as native and naturalized in the study area. The richest families are Asteraceae (62 genera/132 species), Fabaceae (22/79), Poaceae (43/68), Brassicaceae (43/58), Lamiaceae (19/48), and Apiaceae (30/45). The genera Astragalus (20 species) and Convolvulus (14 species) are the most species-rich in Khuz. Raunkiaer’s plant life-form spectrum in the area is dominated by therophytes (33%) and hemicryptophytes (29%). The core flora of Khuz has the Irano-Turanian origin; the widespread elements are also well represented in the study area. The dust sources area includes four types of vegetation: wetland species, hygrophyte plants, terrestrial halophytes, and psammophytic plants. The main sources of dust rise are covered with two classes of vegetation (halophytes and pasmophytes), with 77 dune species, 43 species of salty soil places, and 28 species adapted to both climate and soil of the area.
Revision of the Nearctic species of Gimnomera Rondani (Diptera: Scathophagidae), with morphological phylogeny and DNA barcodes
Authors: CHAGNON MARIE-EVE , SINCLAIR BRADLEY J.
Published: September 2020

The Nearctic species of Gimnomera Rondani are revised and includes eight species, of which three are new to science (G. aquilonia sp. nov., G. cerea (Coquillett), G. cuneiventris (Zetterstedt), G. incisurata Malloch, G. subvittata (Malloch), G. terrywheeleri sp. nov., G. tibialis (Malloch), G. vockerothi sp. nov.). Gimnomera cuneiventris is newly recognized as Holarctic in distribution. Gimnomera fasciventris Malloch is removed and transferred to the genus Acerocnema, comb. nov. An additional Nearctic species is recognized but not described due to lack of male specimens. Species descriptions, diagnoses and distribution maps are presented, including images of the male terminalia as well as additional diagnostic characters. A key to the Nearctic species is also provided. A morphological cladistic analysis of 12 species reveals that the Nearctic and Palearctic species do not form separate monophyletic groups. COI mitochondrial DNA barcode sequences were obtained for eight Nearctic species of Gimnomera.
A new species of Atelopus (Anura: Bufonidae) from southern Peru
Authors: HERRERA-ALVA VALIA , DÍAZ VLADIMIR , CASTILLO ERNESTO , RODOLFO CÉSAR , CATENAZZI ALESSANDRO
Published: September 2020

We describe a new harlequin frog (genus Atelopus) from the cloud forest near Anchihuay (Anco District, Ayacucho Department) from 2000 to 2150 m elevation in southern Peru, representing the first record for the genus in the Department of Ayacucho. The new species has a maximum snout-vent length of 21.5 mm in females and 21.6 mm in males, and resembles A. erythropus in general appearance, small size, and dorsal coloration. The new species can be distinguished from A. erythropus by its unique pattern of ventral coloration, dorsal skin texture, and snout shape. We detected the presence of the pathogenic fungus Batrachochytrium dendrobatidis in individuals of the new species. This pathogen is threatening the survival of harlequin frogs throughout the Neotropics. In addition to chytridiomycosis, habitat loss further threatens the single locality where the new species is known to occur.
Evaluating Climate Models with the CLIVAR 2020 ENSO Metrics Package
Authors: Planton Yann Y. , Guilyardi Eric , Wittenberg Andrew T. , Lee Jiwoo , Gleckler Peter J. , Bayr Tobias , McGregor Shayne , McPhaden Michael J. , Power Scott , Roehrig Romain , Vialard Jérôme , Voldoire Aurore
Published: September 2020

El Niño–Southern Oscillation (ENSO) is the dominant mode of interannual climate variability on the planet, with far-reaching global impacts. It is therefore key to evaluate ENSO simulations in state-of-the-art numerical models used to study past, present, and future climate. Recently, the Pacific Region Panel of the International Climate and Ocean: Variability, Predictability and Change (CLIVAR) Project, as a part of the World Climate Research Programme (WCRP), led a community-wide effort to evaluate the simulation of ENSO variability, teleconnections, and processes in climate models. The new CLIVAR 2020 ENSO metrics package enables model diagnosis, comparison, and evaluation to 1) highlight aspects that need improvement; 2) monitor progress across model generations; 3) help in selecting models that are well suited for particular analyses; 4) reveal links between various model biases, illuminating the impacts of those biases on ENSO and its sensitivity to climate change; and to 5) advance ENSO literacy. By interfacing with existing model evaluation tools, the ENSO metrics package enables rapid analysis of multipetabyte databases of simulations, such as those generated by the Coupled Model Intercomparison Project phases 5 (CMIP5) and 6 (CMIP6). The CMIP6 models are found to significantly outperform those from CMIP5 for 8 out of 24 ENSO-relevant metrics, with most CMIP6 models showing improved tropical Pacific seasonality and ENSO teleconnections. Only one ENSO metric is significantly degraded in CMIP6, namely, the coupling between the ocean surface and subsurface temperature anomalies, while the majority of metrics remain unchanged.