bluuebunny/crossref_metadata_2025 huggingface dataset:
CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC
Authors: Zhang Shuzhen , Wang Jingjing , Chen Yang , Liang Weilian , Liu Hanzhe , Du Ruixue , Sun Yunqing , Hu Chuanyu , Shang Zhengjun
Published: November 2024

Background

Cancer-associated fibroblasts (CAFs), a predominant stromal cell type in the tumor microenvironment, significantly affect the progression of oral squamous cell carcinoma (OSCC).

Results

The specific mechanisms through which CAFs influence the cancer stem cell phenotype in OSCC are not fully understood. This study explored the effects of lactic acid produced by CAFs on the cancer stem cells (CSCs) phenotype of OSCC cells. Our results demonstrated that CAFs exhibit increased glycolysis and lactic acid production. Lactic acid treatment enhances CSCs-related markers expression, sphere formation, and clonogenic ability of OSCC cells. RNA sequencing revealed that lactic acid treatment elevates Discs Large Homolog 5 (DLG5) expression and markedly affects the Hippo pathway. Further investigation revealed that DLG5 mediates the effects of lactic acid on the CSCs phenotype. DLG5 knockdown results in elevated expression of E3 ubiquitin ligase Cullin 3, which can promote the ubiquitination and degradation of MST1, but the expression of phosphorylated MST1 remains unchanged. This leads to enhanced binding of phosphorylated MST1 to YAP1, increasing YAP1 phosphorylation and activating the Hippo pathway.

Conclusion

Collectively, our findings suggest that lactic acid from CAFs promotes the CSCs phenotype in OSCC through the DLG5/CUL3/MST1 axis. Therefore, targeting lactic acid exchange between CAFs and tumor cells may provide a novel therapeutic approach to suppress the CSCs phenotype in OSCC.
Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals
Authors: Alldred Melissa J. , Ibrahim Kyrillos W. , Pidikiti Harshitha , Chiosis Gabriela , Mufson Elliott J. , Stutzmann Grace E. , Ginsberg Stephen D.
Published: November 2024

Selective vulnerability of neuronal populations occurs in both Down syndrome (DS) and Alzheimer’s disease (AD), resulting in disproportional degeneration of pyramidal neurons (PNs) affecting memory and executive function. Elucidating the cellular mechanisms underlying the selective vulnerability of these populations will provide pivotal insights for disease progression in DS and AD. Single population RNA-sequencing analysis was performed on neurons critical for executive function, prefrontal cortex Brodmann area 9 (BA9) layer III (L3) and layer V (L5) excitatory PNs in postmortem human DS and age- and sex-matched control (CTR) brains. Data mining was performed on differentially expressed genes (DEGs) from PNs in each lamina with DEGs divergent between lamina identified and interrogated. Bioinformatic inquiry of L3 PNs revealed more unique/differentially expressed DEGs (uDEGs) than in L5 PNs in DS compared to CTR subjects, indicating gene dysregulation shows both spatial and cortical laminar projection neuron dependent dysregulation. DS triplicated human chromosome 21 (HSA21) comprised a subset of DEGs only dysregulated in L3 or L5 neurons, demonstrating partial cellular specificity in HSA21 expression. These HSA21 uDEGs had a disproportionally high number of noncoding RNAs, suggesting lamina specific dysfunctional gene regulation. L3 uDEGs revealed overall more dysregulation of cellular pathways and processes, many relevant to early AD pathogenesis, while L5 revealed processes suggestive of frank AD pathology. These findings indicate that trisomy differentially affects a subpopulation of uDEGs in L3 and L5 BA9 projection neurons in aged individuals with DS, which may inform circuit specific pathogenesis underlying DS and AD.
The spatial differentiation mechanism of intangible cultural heritage and its integration with tourism development based on explainable machine learning and coupled coordination models: a case study of the Jiang-Zhe-Hu in China
Authors: Shao Dandan , Zoh KyungJin , Xie Yanzhao
Published: November 2024

As a vital carrier of traditional culture, Intangible Cultural Heritage (ICH) not only preserves historical value but also fosters cultural identity and confidence. This study utilizes explainable machine learning and coupled coordination models to analyze the spatial distribution and formation mechanisms of ICH resources in the Jiangsu-Zhejiang-Shanghai (Jiang-Zhe-Hu). The results indicate that (1) ICH resources in the Jiang-Zhe-Hu exhibit a clustered distribution pattern characterized by “three primary cores and two secondary cores.” The primary core areas are Shanghai, Hangzhou, and Suzhou, while the secondary core areas are Yangzhou and Nanjing. (2) Population, number of religious places, and GDP have a significant positive impact on the distribution of ICH in the Jiang-Zhe-Hu. NDVI and road mileage have relatively minor effects on ICH distribution. (3) In terms of ICH resources, Zhejiang Province overall has a higher level than Jiangsu Province, with Lishui having the highest evaluation value and the most abundant resources. Regarding the level of tourism industry development, Shanghai has the highest comprehensive evaluation value, followed by Suzhou, Nanjing, Hangzhou, Wuxi, and Changzhou, all of which have relatively high levels of tourism development. (4) According to the coupled coordination model analysis, Shanghai demonstrates the best coupling degree between ICH resources and the tourism industry, achieving a good coordination level. In Jiangsu Province, the integration of ICH resources and the tourism industry is relatively better in the southern (e.g., Nanjing, Suzhou), but there are still imbalances in development in the northern. Zhejiang Province has an overall higher degree of integration between ICH and the tourism industry compared to Jiangsu, with more balanced development. However, there is still room for improvement in the deep integration of ICH resources with the tourism industry.
Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation
Authors: Karnik Varun , Colombo Sebastiano Maria , Rickards Leah , Heinsar Silver , See Hoe Louise E. , Wildi Karin , Passmore Margaret R. , Bouquet Mahe , Sato Kei , Ainola Carmen , Bartnikowski Nicole , Wilson Emily S. , Hyslop Kieran , Skeggs Kris , Obonyo Nchafatso G. , McDonald Charles , Livingstone Samantha , Abbate Gabriella , Haymet Andrew , Jung Jae-Seung , Sato Noriko , James Lynnette , Lloyd Benjamin , White Nicole , Palmieri Chiara , Buckland Mark , Suen Jacky Y. , McGiffin David C. , Fraser John F. , Li Bassi Gianluigi
Published: November 2024

Open-lung ventilation during cardiopulmonary bypass (CPB) in patients undergoing heart transplantation (HTx) is a potential strategy to mitigate postoperative acute respiratory distress syndrome (ARDS). We utilized an ovine HTx model to investigate whether open-lung ventilation during CPB reduces postoperative lung damage and complications. Eighteen sheep from an ovine HTx model were included, with ventilatory interventions randomly assigned during CPB: the OPENVENT group received low tidal volume (VT) of 3 mL/kg and positive end-expiratory pressure (PEEP) of 8 cm H20, while no ventilation was provided in the NOVENT group as per standard of care. The recipient sheep were monitored for 6 h post-surgery. The primary outcome was histological lung damage, scored at the end of the study. Secondary outcomes included pulmonary shunt, driving pressure, hemodynamics and inflammatory lung infiltration. All animals completed the study. The OPENVENT group showed significantly lower histological lung damage versus the NOVENT group (0.22 vs 0.27, p = 0.042) and lower pulmonary shunt (19.2 vs 32.1%, p = 0.001). In addition, the OPENVENT group exhibited a reduced driving pressure (9.6 cm H2O vs. 12.8 cm H2O, p = 0.039), lower neutrophil (5.25% vs 7.97%, p ≤ 0.001) and macrophage infiltrations (11.1% vs 19.6%, p < 0.001). No significant differences were observed in hemodynamic parameters. In an ovine model of HTx, open-lung ventilation during CPB significantly reduced lung histological injury and inflammatory infiltration. This highlights the value of an open-lung approach during CPB and emphasizes the need for further clinical evidence to decrease risks of lung injury in HTx patients.
Simplified technique in total pancreatectomy with islet cell autotransplantation after Frey’s procedure: a case report
Authors: Oikawa Ryo , Takemura Nobuyuki , Shimoda Masayuki , Nakamura Mai , Mihara Fuminori , Inagaki Fuyuki , Kokudo Norihiro
Published: November 2024

Background

The selection of the surgical approach for chronic pancreatitis (CP) is determined by various factors including inflammatory location, presence of pancreatic duct dilatation, or possibility of cancer. Total pancreatectomy (TP), with or without islet cell autotransplantation, is considered for patients with refractory CP after the failure of other surgical treatments. Considering the increasing incidence of CP requiring surgical treatment, the number of cases in which TP is performed after previous surgical treatment is expected to increase.

Case presentation

We reported a case of TPIAT in a patient with alcoholic CP who had previously undergone Frey’s procedure. During the operation, the sufficient length of the elevated jejunal loop for pancreaticojejunostomy in Frey’s procedure allowed it to be used directly for biliary jejunostomy during TP. In addition, jejunojejunostomy from the previous operation could be used, and these methods contributed to simplifying the operative procedure. We need open hemostasis on post-operative day (POD) 1and a percutaneous drainage tube replacement for an intraperitoneal abscess on POD 24. The patient was discharged from the hospital on POD 37 with normal serum C-peptide level, which suggests favorable insulin secretion from transplanted islets, and the epigastric pain that suffered her preoperatively resulted in a dramatic improvement.

Conclusions

When performing the Frey’s procedure, the elevated jejunal loop and Y-anastomosis jejunal loop with sufficient length allow them to be used directly for the reconstructions in the possible subsequent TP.
Red, green, and blue model assessment and AQbD approach to HPTLC method for concomitant analysis of metformin, pioglitazone, and teneligliptin
Authors: Prajapati Pintu , Patel Pooja , Naik Dhrumi , Haque Anzarul , Shah Shailesh
Published: November 2024

Background

The CDSCO of India has authorized a combination of metformin hydrochloride, teneligliptin hydrochloride, and pioglitazone hydrochloride for the treatment of insulin-independent diabetes. For the purpose of estimating metformin, teneligliptin, and pioglitazone combinations as well as individual commercial formulations, there are a plethora of publicly accessible chromatographic techniques. More importantly, the development of these chromatographic procedures has included the use of chemical solvents that are dangerous to both animals and the environment.

Objectives

However, to date, there has been no documented chromatographic technique that can concomitantly estimate various commercial formulations of drugs under study employing a uniform chromatographic condition and environmentally friendly solvents. In order to concomitantly estimate drugs under study utilizing unified chromatographic conditions, a green HPTLC method was developed.

Method

The AQbD approach was used to carry out the method development. To determine the most important method parameters and response variables, the analytical risk assessment was conducted using the risk priority number ranking and screening approach. Critical method parameters and response variables were modeled using the response surface modeling approach, which relies on the central composite design. Optimal ranges for the intended method operable design region were determined, and control strategy was framed. The chromatographic separation was carried out on preparative TLC plate precoated with silica gel G-60 F254 using 1.0%W/V ammonium acetate in ethanol: water: triethylamine (6.5:0.4:0.6, V/V) as mobile phase. The detection of the anti-diabetic drugs under study was carried out at 267 nm wavelength.

Results

The linearity of metformin, teneligliptin, and pioglitazone was found to be 5000–25000 ng/band, 200–1000 ng/band, and 150–750 ng/band, respectively. The %RSD for robustness and precision study was found to be less than 2.0%. The %recovery of method was found to be 98–102%. The assay results were shown to be in compliance with respective labeled claims of anti-diabetic medications when the suggested method was used for concurrent analysis of several formulations and combinations of drugs under study.

Conclusion

The suggested technique was evaluated utilizing red–green–blue model scoring tools. The suggested technique was determined to be precise, accurate, rapid, cost-effective, and easy to apply for the estimation of drugs under study.
Diversity and Inclusivity Considerations Are Key When Choosing a Global Oncology Conference Location
Authors: El Bairi Khalid , Wondimagegnehu Abigiya , Khan Shah Zeb , Trapani Dario , Abdihamid Omar
Published: November 2024

we propose equity in representation on who hosts cancer related conferences! It's time for Low and middle income to also rent their academic spaces!, this unfortunately is one of the ways to sort the visa injustices for cancer care providers in LMICs
The Sovereignty of Chance
Authors: Urbinati Nadia
Published: November 2024

In the context of the ongoing Common Knowledge symposium “Antipolitics,” this article responds skeptically to the numerous contributions calling for the supplanting of elections by sortition. While lottocracy is proposed as a solution to the flaws of electoral democracy — notably, corruption and violent partisanship — this response focuses on a single theoretical issue: the logic of chance or randomness, which, according to its proponents, should rid politics of corruption and relieve representation of partisanship so as to ultimately prevent the formation of a ruling class separate from the rest of society. The problem with the solution, according to this essay, is that, however useful in many ways, the lottery system of lawmaking is not democratic.
K-line guided approach selection and outcomes assessment for Cervical Ossification of Posterior Longitudinal Ligament (OPLL): A case series with literature review from Pakistan
Authors: Qadri Haseeb Mehmood , Khan Manal , Ansari Nasruddin , Khizar Ahtesham , Bukhari Syed Ahmad Faizan , Bashir Asif
Published: November 2024

Objectives: To analyze the efficacy of K-line in surgical planning of approach selection for ossification of posterior longitudinal ligament (OPLL) and outcomes assessment by Nurick grading and Modified Japanese Orthopaedic Association (mJOA) scores.
Methods: This is a retrospective case series study conducted at the Departments of Neurosurgery, Punjab Institute of Neurosciences, Lahore in the months of January and February 2024. Patients with complete records were considered. Google Form was used for data. Nurick grading and Modified Japanese Orthopaedic Association (mJOA) scores were calculated for each patient pre- and post-operatively. K-line assessment was done on computerized tomography (CT). Data analysis was performed using Microsoft excel in terms of frequency and percentages.
Results: This study included ten patients with the mean age at presentation was 48.20 ± 9.37 years. Preoperative Nurick grading in our patients was Grade-V (five patients), Grade-IV (two patients) and Grade-III (three patients) with mean of 4.2 ± 0.91 SD whereas six months follow-up Nurick grading was Grade-V (three patients), Grade-IV (three patients) and Grade-III (four patients) with the mean of 3.90 ± 0.87 SD, which indicates neurological improvement. Types of OPLL present in our patients were segmental (4, 40%), continuous (3, 30%), mixed (2, 20%) and localized/others (1, 10%). There were 2 (20%) K-line (+) and 8 (80%) K-line (-) cases. Anterior approach was used in 2 (20%) cases whereas posterior approach was used for the rest of 8 (80%) cases. Mean preoperative mJOA was 10.30 ± 2.45 and mean postoperative mJOA was12.40 ± 2.01 at 6-month follow up, which indicates improvement in our cases.
Conclusion: K-line is a useful radiological indicator in selecting anterior versus posterior approach for patients with cervical OPLL in terms of Nurick grading and mJOA scores.
List of Abbreviations:
OPLL: Ossified Posterior Longitudinal Ligament, DISH: Diffuse Idiopathic Skeletal Hyperostosis, CT: Computed Tomography, mJOA: Modified Japanese Orthopaedic Association, BMP: Bone Morphogenetic Protein, TGF-b: Transforming Growth Factor Beta, ACCF: Anterior Cervical Corpectomy and Fusion.
doi: https://doi.org/10.12669/pjms.40.12(PINS).11094
How to cite this: Qadri HM, Khan M, Ansari N, Khizar A, Bukhari SFA, Bashir A. K-line guided approach selection and outcomes assessment for Cervical Ossification of Posterior Longitudinal Ligament (OPLL): A case series with literature review from Pakistan. Pak J Med Sci. 2024;40(12):S63-S68.  doi: https://doi.org/10.12669/pjms.40.12(PINS).11094
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Radiometric and Morphologic Analysis of Arnold Chiari Type-I Malformation and Idiopathic Syringomyelia: A Case Series from Pakistan
Authors: Khan Muhammad Tahir , Kaleem Muhammad , Qadri Haseeb Mehmood , Manzoor Hamza , Shoaib Mahwish
Published: November 2024

Background and Objective: Chiari I Malformation-associated syringomyelia (CM) and idiopathic syringomyelia (IS) are often confused together. They require different diagnostic approach and treatment modalities; it is important to distinguish between the two. We aimed to evaluate the radiological and morphologic characteristics of CM and IS in adult and pediatric patients in Pakistani population.
Methods: Our retrospective case series was conducted at the Department of Radiology, Punjab Institute of Neurosciences assessing the operated cases of CM and IS cases from January 2022 to December 2023. Preoperative morphologic and radiological data was collected for adult and pediatric patients.
Results: Out of 16 patients, 75% were adults and four were children. Twelve patients were male. The mean age of adult patients at presentation was 30.50 ± 9.20 years. There were nine cases of Chiari I Malformation and seven cases of idiopathic syringomyelia. Craniocervical junction (CCJ) was the most common site of syrinx formation in adults (41.66%) in both Chiari I and IS groups. The mean size of syrinx in adults in IS was 7.842 ± 1.93 and in CM was 4.740 ± 0.45. Mean size of syrinx in children was 4.84 ± 0.48 mm. Moniliform shape was the most common form of syrinx in patients in both CM and IS groups.
Conclusion: In the Pakistani population, this study focuses on the radiological characteristics of idiopathic syringomyelia (IS) and Chiari I Malformation (CM), both of which commonly exhibit a moniliform syrinx. The craniocervical junction was frequently involved in CM, but IS exhibited a wider, bigger syrinx. Accurate diagnosis as well as treatment depend on imaging.
doi: https://doi.org/10.12669/pjms.40.12(PINS).11095
How to cite this: Khan MT, Kaleem M, Qadri HM, Manzoor H, Shoaib M. Radiometric and Morphologic Analysis of Arnold Chiari Type-I Malformation and Idiopathic Syringomyelia: A Case Series from Pakistan. Pak J Med Sci. 2024;40(12):S69-S74. doi: https://doi.org/10.12669/pjms.40.12(PINS).11095
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Complexity of arachnoid adhesions dictating the outcome of microvascular decompression for trigeminal neuralgia
Authors: Khokhar Tariq Imran , Cheema Zulqarnain Akram , Fatima Ibreeza , Qadri Haseeb Mehmood , Bashir Raahim , Bashir Asif
Published: November 2024

Objective: Multiple techniques have been used to treat trigeminal neuralgia (TGN), including pharmacotherapy, radiosurgery, rhizotomy and microvascular decompression (MVD). Blood vessels are considered to be the most common cause of offense and compression to trigeminal nerve. We aimed to determine the causes of classic TGN and efficacy of MVD.
Methods: This retrospective, cross-sectional study assessed the data of 53 patients, who underwent MVD at the Department of Neurosurgery, Punjab Institute of Neurosciences, Lahore, Pakistan, from May, 2022 to December, 2023. Information regarding patient demographics, clinical presentation, Barrow Neurological Institute Facial Pain Score (BNI–FPS), intra-operative findings, and postoperative complications were analyzed.
Results: The mean age at presentation was 44.33±11.71 years. Unilateral facial pain was the consistent clinical presentation among all patients, with right-sided involvement in 67.92% patients. All patients had involvement of at least two divisions of trigeminal nerve; maxillary and mandibular nerve in 84.91% and 71.70% cases, respectively. BNI–FPS Grade-IVb was found among 49.09% patients on presentation. Arachnoid adhesions, superior cerebellar artery and superior petrosal vein were the most common causes of compression in 71.70%, 50.94% and 43.40% cases, respectively. About 94% patients were discharged home on first post-operative day without complications and with BNI–FPS Grade-I.
Conclusions: Microvascular decompression is highly advocated in classic cases of TGN. In the absence of grossly visible offending vascular structure, arachnoid adhesions should be the thorough focus of address.
doi: https://doi.org/10.12669/pjms.40.12(PINS).11128
How to cite this: Khokar TI, Cheema ZA, Fatima I, Qadri HM, Bashir R, Bashir A. Complexity of arachnoid adhesions dictating the outcome of microvascular decompression for trigeminal neuralgia. Pak J Med Sci. 2024;40(12):S15-S19. doi: https://doi.org/10.12669/pjms.40.12(PINS).11128
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The domino effect and emotional dysregulation in neurosurgeons
Authors: Fatima Shahar Bano
Published: November 2024

doi: https://doi.org/10.12669/pjms.40.12(PINS).11130
How to cite this: Fatima SB. The domino effect and emotional dysregulation in neurosurgeons. Pak J Med Sci. 2024;40(12):S130. doi: https://doi.org/10.12669/pjms.40.12(PINS).11130
Γιώργος Θεοτοκάς και χριστιανισμός
Authors: Ψάλτης Ηρακλής
Published: November 2024

Η διδακτορική διατριβή εξετάζει τη σχέση του Γιώργου Θεοτοκά με τον Χριστιανισμό και την Ορθόδοξη Εκκλησία. Πρόκειται για μια σχέση που εξελίσσεται και διαμορφώνεται σταδιακά· ξεκινά από την αρνησιθρησκία των νεανικών του χρόνων (1927-1940), προχωρά στη θρησκευτική επανεκτίμηση (1941-1959), και καταλήγει στη βαθύτερη θρησκευτική γνωριμία (1960-1966), η οποία διακόπτεται από τον απρόσμενο θάνατό του. Παρουσιάζεται περιληπτικά, επίσης, και το ευρύτερο κοινωνικοπολιτικό και πνευματικό πλαίσιο της εποχής.
Μελέτη του οξειδωτικού στρες σε ασθενείς με μυελοδυσπλαστικά σύνδρομα
Authors: Τσιάρα Ελένη
Published: November 2024

Εισαγωγή: Μελέτες έχουν δείξει ότι το οξειδωτικό στρες μπορεί να επιδράσει στην αναγέννηση, τον πολλαπλασιασμό και τη διαφοροποίηση των αιμοποιητικών βλαστικών κυττάρων. Αυξημένα επίπεδα οξειδωτικού στρες επηρεάζουν λειτουργίες βασικών βιομορίων όπως το DNA, οι πρωτεΐνες και τα λιπίδια, σχετίζονται με την παθογένεση ενός ευρέως φάσματος ασθενειών. Μια τέτοια κατηγορία ασθενειών αποτελούν τα μυελοδυσπλαστικά σύνδρομα (ΜΔΣ) στα οποία το οξειδωτικό στρες μπορεί να επηρεάσει τα κύτταρα του αίματος, όπως ερυθροκύτταρα (RBCs), αιμοπετάλια και ουδετερόφιλα, επιδεινώνοντας την αναιμία και προκαλώντας επαναλαμβανόμενες λοιμώξεις και θρομβωτικά συμβάντα, αντίστοιχα. Σκοπός: Η παρούσα μελέτη επικεντρώθηκε σε ασθενείς με επιβεβαιωμένο Μυελοδυσπλαστικό Σύνδρομο και σκοπός της αποτέλεσε η διερεύνηση του ρόλου του οξειδωτικού στρες στο συγκεκριμένο σύνδρομο. Υλικά και μέθοδοι: Στη μελέτη συμπεριελήφθησαν 51 ασθενείς με ΜΔΣ, 28 άντρες και 23 γυναίκες με διάμεση ηλικία τα 70 έτη (εύρος 55-86 έτη), οι οποίοι νοσηλεύθηκαν ή επισκέφτηκαν στα εξωτερικά ιατρεία του Αιματολογικού Τμήματος του Πανεπιστημιακού Γενικού Νοσοκομείου Λάρισας (ΠΠΓΝΛ) και 44 υγιείς μάρτυρες με απουσία διαταραχών της μυελικής σειράς, (24 άνδρες και 20 γυναίκες) και με διάμεση ηλικία τα 71 έτη (εύρος 64-77 έτη). Σε δείγματα αίματος μετρήθηκαν φασματοφωτομετρικά, 5 βιοδείκτες προσδιορισμού των επιπέδων οξειδωτικού στρες. Οι βιοδείκτες αυτοί ήταν τα πρωτεϊνικά καρβονύλια, ένας δείκτης οξείδωσης πρωτεϊνών (CARB), οι ουσίες που αντιδρούν με το θειοβαρβιτουρικό οξύ, δείκτης οξείδωσης λιπιδίων (TBARS), η ολική αντιοξειδωτική ικανότητα του πλάσματος (TAC), τα επίπεδα της ανηγμένης γλουταθειόνης (GSH), και ο ρυθμός αποικοδόμησης του H2O2, μέσω δράσης του ενζύμου της καταλάσης (CAT). Τα επίπεδα των βιοδεικτών των ασθενών με ΜΔΣ συγκρίθηκαν και συσχετίστηκαν με τα αντίστοιχα δεδομένα από τους 44 υγιείς μάρτυρες. Αποτελέσματα: Από τα αποτελέσματα των βιοδεικτών που μελετήθηκαν προέκυψε ότι η δραστικότητα της καταλάσης και τα επίπεδα της πρωτεϊνικής οξείδωσης δεν επηρεάστηκαν σημαντικά στους ασθενείς με ΜΔΣ σε σχέση με την ομάδα ελέγχου. Από την άλλη, τα επίπεδα των TBARS και της TAC παρουσίασαν στατιστικώς σημαντική αύξηση, με ταυτόχρονη σημαντική μείωση των επιπέδων της GSH στην ομάδα των ασθενών με ΜΔΣ σε σχέση με τους υγιείς. Συμπέρασμα: Στην παρούσα διπλωματική εργασία παρατηρήθηκε διαταραχή της οξειδωτικής ομοιόστασης στους ασθενείς με ΜΔΣ, σε σχέση με τα υγιή άτομα που συμμετείχαν στη μελέτη. Φαίνεται ότι το οξειδωτικό στρες εμπλέκεται στην ανάπτυξη του μυελοδυσπλαστικού συνδρόμου και οι ασθενείς με ΜΔΣ δεν έχουν επαρκώς ανεπτυγμένους τους αντιοξειδωτικούς μηχανισμούς τους.
Η προστασία της οικογενειακής ζωής των αλλοδαπών
Authors: Παπάλα Βαλεντίνη
Published: November 2024

Η μετανάστευση ως μείζον κοινωνικό φαινόμενο, απασχολεί σήμερα τις περισσότερο αναπτυγμένες χώρες του κόσμου, δεδομένου ότι στο πλαίσιο της παγκοσμιοποίησης και της βιομηχανικής ιδίως ανάπτυξης των μεγάλων αστικών κέντρων, διευκολύνονται οι μαζικές μετακινήσεις πληθυσμών. Οι θεσμοί της Ε.Ε έχουν μεριμνήσει ώστε να πλαισιωθούν νομοθετικά αλλά και να προασπιστούν τα θεμελιώδη δικαιώματα των προσφύγων και μεταναστών. Η Ελλάδα, προέχοντος λόγω της ανάπτυξης της, όσο και της γεωγραφικής της θέσης, γνώρισε τη διόγκωση του μεταναστευτικού φαινομένου που παρατηρήθηκε και στις υπόλοιπες χώρες – ενδεχομένως και σε μεγαλύτερο βαθμό- και μετατράπηκε σταδιακά από χώρα αποστολής σε χώρα υποδοχής μεταναστών, γεγονός που καθιστά αναγκαία την υιοθέτηση μέτρων ορθολογικής διαχείρισης του φαινομένου αυτού. Οι μελέτες διεθνών οργανισμών καταδεικνύουν ότι η Ελλάδα είναι η Ευρωπαϊκή χώρα με την μεγαλύτερη σχετική αύξηση του ποσοστού αλλοδαπών υπηκόων επί του συνολικού πληθυσμού κατά τα τέλη του 20ου αιώνα. Η Ελλάδα, ως χώρα υποδοχής πολιτών τρίτων χωρών, κλήθηκε να ανταπεξέλθει στην προάσπιση αλλά και εφαρμογή του δικαιώματος για οικογενειακή επανένωση, κυρίως τα τελευταία πέντε χρόνια λόγω της ραγδαίας αύξησης των προσφυγικών και μεταναστευτικών ροών. Στο πλαίσιο της διδακτορικής διατριβής ασχολήθηκα με το δικαίωμα της οικογενειακής ζωής των αλλοδαπών στους οποίους συμπεριλαμβάνονται οι μετανάστες, πρόσφυγες, οι αιτούντες άσυλο και η ειδική κατηγορία ευάλωτης ομάδας ασυνόδευτοι ανήλικοι. Το εν λόγω δικαίωμα είναι για ποικίλους λόγους ιδιαίτερης σημασίας στο πεδίο του δικαίου, που αφορά τις ανωτέρω ευπαθείς ομάδες της κοινωνίας. Η απρόσκοπτη συνύπαρξη του αλλοδαπού μετανάστη αλλά και του δικαιούχου διεθνούς προστασίας με την οικογένεια του στην χώρα υποδοχής, δεν συνιστά απλώς ένα δικαίωμα του. Είναι ταυτόχρονα ένας καταλύτης για την ομαλή ένταξη και συμμετοχή του στην κοινωνία που τον υποδέχεται, καθώς πρόκειται για ένα κοινωνικό, υπό ευρεία έννοια δικαίωμα, που συνδέεται άμεσα με το ατομικό δικαίωμα της ελεύθερης ανάπτυξης της προσωπικότητας κάθε ατόμου. Για τον λόγο αυτό η οικογένεια του αλλοδαπού ανεξαρτήτως της ιδιότητας του ως μετανάστη ή δικαιούχου διεθνούς προστασίας ή και αιτούντος διεθνή προστασία τυγχάνει προστασίας σε διεθνές, ενωσιακό και εθνικό επίπεδο. Οι θεσμοί της Ε.Ε έχουν μεριμνήσει ώστε να πλαισιωθούν νομοθετικά αλλά και να προασπιστούν τα θεμελιώδη δικαιώματα των προσφύγων και μεταναστών. Η εργασία γύρω από την δημιουργία νομοθετικών και μη κειμένων αποτέλεσε χρονοβόρα διαδικασία της οποίας την ανάγκη ανέδειξαν οι συνθήκες στο εσωτερικό της ένωσης αλλά και στο διεθνές επίπεδο. Η παρούσα διατριβή αποτελείται από τις κάτωθι ενότητες:- Η επιταγή της προστασίας της οικογένειας,- Η προστασία των οικογενειών των αλλοδαπών στο διεθνές δίκαιο,- Η προστασία της οικογένειας στο πεδίο του δικαίου της διεθνούς προστασίας- Λοιπές περιπτώσεις επανένωσης οικογενειών,- Πρόσφατες νομολογιακές εξελίξεις του Ευρωπαϊκού δικαστηρίου Ανθρωπίνων δικαιωμάτων,- Συζήτηση , Συμπεράσματα
Corporate Volunteering. Mapping the Conceptual and Intellectual Structure of the Research Field
Authors: Glińska-Neweś Aldona , Hatami Akram , Hermes Jan
Published: November 2024

The book focuses on humanistic aspects of contemporary management, generating win-win-win opportunities for companies, their employees and societies the companies operate in. Corporate volunteering is one of the ways to navigate for sustainable future in the unpredictable world in which various forces such as global pandemics, wars, unsustainable business practices, and uncertainty play a major role. Corporate volunteering refers to employees’ engagement in company-sponsored volunteering activities, i.e. giving employee time, knowledge, or skills without additional compensation or remuneration, during a planned activity encouraged and supported by a company, in favor of external beneficiaries. Together with donations, strategic philanthropy and community-driven development, corporate volunteering is regarded among modes through which companies support communities with financial or material resources and human skills.

The aim of the book is to map the thematic coverage and intellectual structure in research on corporate volunteering in order to identify leading research streams in the field. To achieve the aim of the study, the combination of research methods was employed, including science mapping methods (i.e. co-word analysis, bibliographic coupling, and direct citation analysis) and a systematic literature review. Mapping of the research field conceptual and intellectual structures provides valuable contribution for all researchers interested in theory and practice of corporate volunteering. A comprehensive map of the field is to allow them to navigate more consciously through a variety of themes, topics and core publications, and their mutual relationships, delivering guidelines to follow one of leading streams of research or to discover a research gap.
Efficient repair of the flexor digitorum profundus tendon at the insertion site using the loop suture technique: a case series
Authors: Kim Jae Woo , Kim Jin Soo , Roh Si Young , Lee Kyung Jin , Lee Dong Chul
Published: November 2024

Purpose: This study presents the outcomes of a modified loop-locking suture technique for repairing complete flexor digitorum profundus (FDP) tendon divisions at the terminal level. Traditional methods, such as pullout sutures or tendon fixation, are commonly used; however, this paper explores the reliability of the loop-locking suture technique.Methods: From June 2011 to January 2024, the modified loop-locking suture technique was performed in 21 cases of FDP tendon division in which the distal stump was less than 1 cm in length. Core and epitendinous sutures were made using polydioxanone 4-0 and poliglecaprone 25 4-0. The study focused on 13 patients aged 24 to 68 years, with an average tendon stump length of 0.61 cm. Ten cases necessitated microsurgical repair involving both arterial and nerve repair. A dorsal protective splint was used for an average of 5 weeks. The outcomes measured included active and passive range of motion, grip strength, and key and pulp pinch.Results: The mean follow-up period was 12 months. No re-ruptures occurred, although two cases required tenolysis. The average active range of motion at the distal interphalangeal joint was 61.5°. Grip strength and pulp pinch averaged 95.3% and 86.8%, respectively, compared to the contralateral side. Flexion contracture was observed in three cases, with no quadriga effect.Conclusion: The modified loop-locking suture technique provides sufficient functional recovery for FDP tendon divisions in Zone 1a and distal Zone 1b, even with a short tendon stump.
Not All Lines Are Skipped Equally: An Experimental Investigation of Line-Sitting and Express Lines
Authors: Althenayyan Abdullah , Ülkü Sezer , Yang Luyi , Cui Shiliang
Published: November 2024

Problem definition: In this paper, we investigate how line-sitting and express lines affect customers’ satisfaction and fairness perception about queues. In line-sitting, customers skip the wait by hiring others to stand in line on their behalf. In express lines, customers skip the wait by purchasing priority. Because both schemes disrupt the first-in-first-out (FIFO) rule, they may be perceived to be unfair and lead to customer dissatisfaction. Methodology/results: In three experiments, we find that customers are more satisfied with the overall queueing experience when they encounter a line-sitter than when they encounter an express-line customer, even when the wait time is held constant. We also find that customers perceive express lines as less fair than line-sitting, which has a significant influence on their satisfaction. A key operational difference between line-sitting and express lines is that line-sitting involves a one-to-one swap between a line-sitter doing a fair share of waiting and their client, whereas express lines insert a new priority customer into the queue without an existing surrogate in the queue. We show that if line-sitting includes an insertion by letting a line-sitter hold a spot for more than one customer, then line-sitting is perceived to be just as unfair and unsatisfying as express lines. Managerial implications: Our results imply that express lines can engender a lower fairness perception, thus harming future business through both more negative word of mouth and a higher customer churn. Therefore, service providers should beware of customer backlash against express lines and yet be more open-minded about line-sitting, provided that one-to-one swaps can be enforced.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0338 .
Donde hubo monte, ratones espinosos mexicanos quedan
Authors: Aguilar Montiel Fernando , Rodríguez-Martínez María Luisa , Aguilera-Miller Eduardo Felipe
Published: November 2024

En los últimos sesenta años, el paisaje rural ha cambiado drásticamente. Donde nuestros abuelos contemplaban importantes extensiones de bosque, ahora nuestros hijos observan interminables campos de cultivo, terreno sin vegetación original o fragmentado. Es en este paisaje donde ha prosperado el ratón espinoso mexicano.
¡Del campo al plato! Carne de monte y zoonosis
Authors: Rodríguez-Luna César R. , Espinal-Palomino Román , Ibarra-Cerdeña Carlos N.
Published: November 2024

La cacería de subsistencia se refiere al aprovechamiento de fauna silvestre para obtener proteína animal para autoconsumo. Aunque esta práctica representa una solución para incorporar proteína en la dieta básica, también expone a las personas a riesgos significativos para la salud.
Murciélagos del sureste de Coahuila
Authors: Olivera-Triste M. Aylin , Ramírez-Albores Jorge E. , Encina-Domínguez Juan E.
Published: November 2024

La percepción humana de los murciélagos varía mucho según las culturas y creencias populares. A lo largo de la historia, estos mamíferos han sido parte de mitos, supersticiones y simbolismos que influyen en cómo se les percibe, desde la asociación con la oscuridad, vampirismo, hasta portadores de rabia y enfermedades.
Las focas de puerto del Pacífico mexicano
Authors: Ortega-Borchardt José Ángel , Heckel Gisela , Schramm Yolanda
Published: November 2024

Observar y estudiar a las focas de puerto del Pacífico en su hábitat natural es una experiencia única y poco común. Aunque la apariencia física de las focas de puerto es familiar para la mayoría, su historia natural sigue siendo, en muchos aspectos, un misterio.
Córdoba y sus mamíferos: tradición, cacería y conservación
Authors: Racero-Casarrubia Javier
Published: November 2024

El departamento de Córdoba ubicado al sur de la región Caribe se convierte en un sitio de interés para la conservación de los mamíferos por su gran diversidad. Sin embargo, muchas especies presentan peligros de conservación por fenómenos como la destrucción de los ecosistemas, transformaciones del territorio y la cacería sobre algunos medianos y grandes mamíferos.
Bitácoras callejeras y noches de murciélagos
Authors: Alanis-Hernández Luis A.
Published: November 2024

Danzando en el cielo de noches oscuras se encuentran aquellos seres casi imperceptibles, recorriendo millas y cobrando tarifas por los servicios que prestan al ecosistema, en busca de su preciado tesoro. “Vendería mi alma por ti y por dinero para gastar contigo, te daré todo hasta quedarme sin nada solo por tenerte a mi lado”, a media noche dijo el murciélago a la flor.
Os Novos Contornos Legais Da Possibilidade De Prorrogação Do Stay Period Na Recuperação Judicial Após A Reforma Pela Lei 14.112/2020
Authors: Baptista da Silva Neto João , Da Silva Sant’Anna Leonardo
Published: November 2024

O presente trabalho tem como objetivo analisar a possibilidade de prorrogação do stay period no curso do processo de recuperação judicial por período superior ao estabelecido na lei nº 11.101/2005 com a redação que lhe foi dada pela lei nº 14.112/2020. Não obstante a positivação da possibilidade de prorrogação do stay period, de forma excepcional e limitada, para que no total compreenda o período máximo de 360 dias, empiricamente se observa que esse prazo ainda é insuficiente para que haja deliberação do plano apresentado pelo devedor. Portanto, considerando o transplante ao ordenamento nacional da faculdade de os credores apresentarem versão alternativa do plano de recuperação judicial na hipótese de superação do stay period e a ocorrência de renovação do prazo de blindagem na hipótese, mostra-se relevante pesquisar a possibilidade da concessão judicial de novas prorrogações após o esgotamento do prazo autorizado na norma. O estudo foi realizado adotando-se o método indutivo com a realização de análise documental e bibliográfica, promovendo pesquisa de julgados proferidos pelo Superior Tribunal de Justiça e pelo Tribunal de Justiça do Estado do Rio de Janeiro sobre a matéria, partindo do marco referencial que decorre da pesquisa realizada por Guilherme Bonato Campos Caramês e Marcia Carla Pereira Ribeiro. Ao fim, constatou-se que a possibilidade de prorrogação do stay period, após a reforma promovida pela lei nº 14.112/2020 é medida excepcional a ser adotada exclusivamente nas hipóteses legalmente estabelecidas na norma em razão dos objetivos e ferramentas jurídicas instituídas pelo legislador reformista.
A formação em um curso de licenciatura em educação do campo na área ciências da natureza:
Authors: Alencar dos Santos Luana , Leite dos Santos Silva Alexandre , Gomes Lopes Suzana
Published: November 2024

A educação do campo surgiu a partir das lutas dos movimentos sociais por uma educação de qualidade, assegurando dignidade de trabalho e ensino aos povos do campo. Com essa preocupação, foram criados os cursos de licenciatura em educação do campo, que precisam propiciar, na perspectiva histórico-crítica, conteúdos culturais-cognitivos, além do preparo pedagógico-didático para a formação de professores. Considerando essas especificidades, o objetivo deste trabalho foi discutir a formação em um curso de licenciatura em educação do campo, na área de ciências da natureza, da Universidade Federal do Piauí. Os dados foram coletados entre 2018 e 2019 por meio de pesquisa documental e entrevistas semiestruturadas. Os resultados mostraram que a maior parte da carga horária do curso é dedicada às ciências da natureza, principalmente à biologia. Mais de 90% dos participantes da pesquisa afirmaram se sentirem preparados para lecionarem a disciplina de biologia, porém menos de 50% se sentem preparados para ensinar química e física, evidenciando a fragilidade na formação voltada para o ensino dessas duas disciplinas. Dentre os motivos apontados pelos sujeitos da pesquisa para não se sentirem preparados, a grade curricular do curso analisado foi o mais citado.
Concepções sobre educação sexual de professores da educação de jovens e adultos de uma escola do campo do município de Antônio Cardoso (BA)
Authors: De Oliveira Cerqueira Cristiane , Pereira de Lima Mendes Maricleide
Published: November 2024

Este artigo tem como objetivo compreender as concepções sobre sexualidade de docentes da Educação de Jovens e Adultos (EJA) de uma escola do campo do município de Antônio Cardoso (BA). Para tanto, partimos do pressuposto de que tais concepções contribuem para a constituição das práticas pedagógicas. O estudo caracterizou-se como descritivo e exploratório, com abordagem qualitativa e as informações foram obtidas por meio da aplicação de um questionário com cinco questões abertas para 12 (doze) professores que atuam na EJA Campo e analisadas com base na análise de conteúdo temática. O referencial teórico norteador da pesquisa foi o dos estudos da sexualidade. Como resultados, identificamos que as concepções de sexualidade são baseadas em discursos preventivistas e heteronormativos, que produzem diferentes efeitos na prática docente. Concluímos que a inclusão da temática sexualidade na formação de professores, a partir de uma perspectiva posicionada contra a patologização e a ações heteronormativas, é um ato político voltado à garantia dos direitos humanos e que o desafio de trabalhar a Educação Sexual dentro de questões não só biológicas, mas, também, histórica, social e cultural é urgente e atual.
Concepção de ensino-aprendizagem da leitura do programa Tempo de Aprender:
Authors: Monteiro Vieira Costa Dania , Mendes Gontijo Cláudia Maria
Published: November 2024

Este artigo tem por objetivo analisar como o programa de formação de professores alfabetizadores Tempo de Aprender, proposto pela Política Nacional de Alfabetização (PNA), lançada em 2019, articula a relação ensino-aprendizagem da leitura no contexto de sua proposta formativa. Adota, como metodologia de estudo, a pesquisa documental, pois analisa os vídeos que compõem os sete módulos do programa, os textos explicativos de cada vídeo e as fichas de estratégias de ensino. Assume a perspectiva enunciativo-discursiva de linguagem conforme proposta por Mikhail Bakhtin, que compreende que essa concepção, atrelada aos conceitos de alfabetização e de leitura, permite, ao mesmo tempo, reivindicar, a despeito do programa, uma alfabetização crítica. Conclui que, apesar de o programa apregoar que se fundamenta em práticas inovadoras por meio da denominada “alfabetização baseada em evidências científicas”, retoma, a partir dos pressupostos bloomfieldianos, antigas práticas relacionadas com as metodologias fônicas para o ensino da leitura e da escrita.
Inclusão educacional e TDIC:
Authors: Dos Santos Souza Evaneyde , Alilma Silva Souza Ferrete Anne , Melo de Andrade Joanna Angélica
Published: November 2024

O presente artigo é oriundo de uma das etapas da pesquisa intitulada “Mediação Docente e Tecnologia Digital de Informação e Comunicação (TDIC) na Perspectiva da Educação Inclusiva”, a qual visa discutir a atuação docente e estratégias pedagógicas inclusivas. Alicerçamos o referido estudo sob a análise dos trabalhos científicos depositados no Banco de Teses e Dissertações da Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) e no catálogo de teses e dissertações do Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) com o objetivo de analisar como a articulação entre a temática da inclusão educacional e as práticas docentes por meio das TDIC são apresentadas em pesquisas acadêmicas e tomando como marco o ano de 2015, quando foi instituída a Lei Brasileira da Inclusão de Pessoas com Deficiência. Esta fase de levantamento bibliográfico foi de suma importância para o reconhecimento das aproximações e distanciamentos dos atuais trabalhos com o objetivo da pesquisa em analisar as mediações pedagógicas, a partir dos recursos digitais, tendo em vista a educação inclusiva. Os dados mostraram uma tendência às discussões sobre a inclusão no aspecto das políticas públicas e também às tecnologias assistivas. Poucos estudos se referiram à inclusão e atuação docente tendo os recursos da TDIC como estratégias pedagógicas – em que se insere, portanto, o foco deste artigo.
Análise das metas de valorização docente do Plano Nacional de Educação (2014-2024) e perspectivas para novo decênio (2024-2034)
Authors: Heitich da Silva Farias Beatriz , Wagner Flávia
Published: November 2024

Este artigo investiga as metas 15, 16, 17 e 18 do Plano Nacional de Educação (PNE) 2014-2024, que tratam da valorização dos profissionais da educação. O objetivo é analisar os avanços e desafios dessas metas, especialmente no contexto de planejamento do novo PNE 2024-2034. Foram revisados o documento final da Conferência Nacional de Educação (CONAE, 2024) e os Relatórios do 4º e 5º Ciclo de Monitoramento das Metas do PNE 2014-2024. A análise fundamenta-se nos trabalhos de Evangelista e Shiroma (2007), Libâneo (2015), Oliveira (2015) e Silva e Santos (2022). O estudo adota uma abordagem qualitativa, com análise bibliográfica e documental, e utiliza o método de análise de Bardin (2020). Conclui-se que, apesar de avanços significativos na formação inicial de professores e na ampliação da oferta de cursos de pós-graduação (Metas 15 e 16), persistem desafios substanciais na equiparação salarial e na implementação de planos de carreira (Metas 17 e 18). A desigualdade regional e a falta de infraestrutura adequada continuam a ser barreiras críticas, destacando a necessidade de políticas mais eficazes e de um monitoramento rigoroso para o próximo decênio.