bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of congenital heart disease in neonates: clinical profile, diagnosis, immediate outcome and short-term follow-up
Authors: Ravilala Vinod Kumar , Kotla Sreenivas , T. Radhakishan , Malava Ranjeet
Published: June 2018

Background: Congenital heart disease (CHD) occurs in approximately 0.8% of live births. Early recognition of CHD is important for appropriate management and decision making regarding referral. The purpose of this study was to document the common presenting symptoms and signs in the neonates with CHD, definitive diagnosis and short-term follow-up for six months.Methods: Sixty full term neonates with suspected CHD admitted in neonatal intensive care unit (NICU) at Niloufer Hospital, Hyderabad during the period December 2016 to May 2017 were included in the study.Results: Of the 60 neonates, most common age of presentation was for first week (45%, n = 27). Of the 60 neonates, 32 (54%) were males and 28 (46%) were females. The commonest presentation was hurried respiration (68%), followed by feeding problem (63%) and only eight neonates were asymptomatic with clinically significant murmur. 40% (n = 24) of the babies were born of consanguineous marriage. 72% (n = 43) of babies presented with murmur and 6 babies had extra-cardiac manifestations. Babies with acyanotic CHD were 38 (63%) of which ventricular septal defect (VSD) was the commonest. Cyanotic CHD were 22 (37%) of which transposition of great arteries (TGA) was the commonest. 25 babies (42%) expired during neonatal period. Of the remaining babies during follow-up, 29 % of babies thrived well, 35% presented with repeated respiratory tract infections, 21% with failure to thrive and 15% with congestive heart failure (CHF).Conclusions: Neonates with CHD have a unique presentation and they carry poor outcome unless diagnosed early and managed appropriately. Babies presenting with multiple anomalies should be screened for any underlying structural heart disease.
A Evaluation On Training Program Candidates For Head Of School Library to Teachers in Bengkulu Province
Authors: Adi Adisel , . Suryadi , Eko Widodo Suparno
Published: June 2018

Abstract

 

This study is aimed to evaluate the legal basis and goal of the training program, the training program resources, the implementation process of training program, and the result of the training program for candidate of school library head to the teachers in elementary school, junior high school, senior high school and vocational high school in Bengkulu Province. The quantitative method using Context, Input, Process, and Product (CIPP) is as the evaluation model. The method is performing by using several approaches including the observations, interviews, and documentations. The results show that the training program is consistent with the standard and criteria of the training program. The resultsreveal that the program has a clear basis and purpose. The training program resources also have also qualified with the standard and criteria. In addition the implementation of education and training program has been run in accordance with the objectives of training program. The result of the training program in improving the competence of candidate head of school library in general in the "good" category. Specifically the products of the training program must be maintained and should be increased as much as possible.

 

Key Words: Implementation process of training program.
Effects of Unmanaged Sports-Related Conflicts among Colleges of Education Students in Ghana.
Authors: Sorkpor Richmond Stephen , Araba Forson Emily , Tsorhe Bismark
Published: June 2018

The purpose of the study was to unravel and analyze effects of sports-related-conflicts in the Central-Western Zone of Colleges of Education in Ghana. Quantitative descriptive survey was used to unravel the effects of sports-related-conflicts among students in the Colleges of Education in the Central Western zone. A questionnaire was administered to 369 respondents. Data collected was analyzed using descriptive statistics. It was revealed that the effects of sports-related-conflicts assumed different forms including; creation of state of chaos, destruction of property, retaliation, sowing seeds of bitterness, rough play action, suspicion, unnecessary tensions, blackmailing among others. It was recommended that conflicts in sports at the Colleges of Education in Ghana should be properly managed by the organizers of the sporting activities
The Effect of Emotional Intelligence, Quality of Work Life, and Stress on Job Satisfaction and Turnover Intention Among The Employees
Authors: Aryanto Tossy , Asmawi Moch. , Ramly Mansyur
Published: June 2018

This study was conducted to find out the information about the effect of emotional intelligence, quality of work life, and stress on job satisfaction and turnover intention among the employees of IPC Port Equipment in Indonesia. The study uses a sample of 175 employees from headquarter and 11 branches of IPC Port Equipment. The empirical testing indicated that both emotional intelligence and quality of work life have positive effect on job satisfaction and have negative effect on turnover intention; stress has negative effect on job satisfaction and has positive effect on turnover intention; job satisfaction has negative effect on turnover intention.
A Correlational Study On Internal Control System Efficiency And Operational Sustainability Of Selected Savings And Credit Cooperatives In The Camanava Area Of Metropolitan Manila
Authors: Miniano Carl Mark B. , Concepcion Maria Christina P.
Published: June 2018

The research delved on determining the relationship between internal control system efficiency and operational sustainability of selected savings and credit cooperatives in CAMANAVA Area, Metropolitan Manila, Philippines. The descriptive research method was utilized employing both quantitative and qualitative approaches. Survey questionnaires, in-depth personal interview, and focused group discussions (FGDs) were used to gather relevant data from selected employees/staff, committee members and executive officers of the subject savings and credit cooperatives. Quantitative data were statistically processed using Analysis of Variance (ANOVA) and Pearson Correlation Coefficient (Pearson’s r). Qualitative data were coded, patterns and relationships analyzed, and findings summarized into themes. The result of the study revealed that the internal control system of savings and credit cooperatives specifically in terms of the control environment, risk assessment, information and communication, control activities, and monitoring have a strong relationship with the cooperatives’ operational sustainability, particularly in political, economic, social, technological, and legal aspects. The study further revealed that the cooperatives face certain problems in the areas of employee recruitment and selection, innovation, credit investigation, and complaints handling.
Librarian’s Perception on Marketing of Information Resources and Services in Academic Libraries with Special Reference to Amhara Region, Ethiopia
Authors: Ramadevi Dr. V.
Published: June 2018

In the present scenario, information and communication technology plays a very important role. Due to the development of technology, internet has brought out some of the opportunities and challenges which provide the effective way of use the library information resources and services. Users can access the required information online irrespective of visiting the place and collecting the information as like ancient days. To improve some of the problems of information and communication technology resulting in underutilization of academic libraries, effort directed to promoting and creating awareness of library services is very important. Library staff can promote the use of the library through other means such as marketing of library services to its users. The role of academic libraries and information centres is to provide necessary information. The objectives of the study were why libraries should market their information resources and services; ways in which libraries market their information resources and services also impacts of marketing information resources and services in the academic Library. The study target population was 120 which comprised of library staff members. The study sample consisted to twenty members of the target group.
Correlates Corelates of Performance of Athletes in Eastern Samar State University
Authors: Lacaba Alvin Bituaran , Lacaba Teresita Villa Golosino
Published: June 2018

ABSTRACT

Title of Research : Correlates with the Performance of Athletes in the Eastern Samar Samar State University- GuiuanResearcher : Alvin B. LacabaCo-Author : Teresita Villa G. Lacaba

Keywords; Performance, Coaching skills, Technical skills, Competency, Professional preparation. This study was conducted to Correlates with the Performance of Athletes in the Eastern Samar State University, Guiuan, Specifically, this study answered the following:1. What is the level of competency of the faculty-coaches in terms of:2.1 Professional preparation2.2 Coaching skill 2.3 Technical skill? 2. What is the level of performance of athletes in the sports competition? 3. Is there a significant relationship between : 3.1. level of competency of faculty-coaches, and level of performance of athletes? This study employed descriptive-correlation which involved 30 faculty-coaches in the Eastern Samar Samar State University- Guiuan. Data were retrieved using a survey questionnaire. These were tallied and analyzed using appropriate statistical tools such as percentage, mean, Pearson product-moment correlation.Findings of the study revealed the following information: The competency of the faculty-coaches in terms of professional preparation, coaching skill, and technical skill of the faculty-coaches were all significantly associated to the performance of athletes. Hence, it was deduced that faculty-coaches who rated themselves higher in these criteria can motivate and train better athletes. Based on the findings of this study, the following conclusions are drawn:The faculty-coaches were regarded competent since they were professionally prepared for sports, with very good coaching skill and technically capable to handle their respective event or game. From the findings of the study, the following recommendations are offered:An organized sports training program should be implemented in the school or division so that all faculty-coaches will be given the chances to be trained especially the new ones.Further studies maybe conducted to validate the findings of this study.
Proposiciones teóricas de base para una concepción de Sistemas de Información de Marketing
Authors: Gómez García Luis Demetrio
Published: June 2018

El concepto Sistema de Información de Marketing (sim) surge en los años 60 del siglo xx como respuesta al avance experimentado en esa década por las Tecnologías de la Información y la Comunicación (tic). Sin embargo, en la actualidad, nuevas denominaciones de Sistemas de Información de soporte al marketing de las organizaciones parecen haber desplazado el concepto original. En este artículo, el autor analiza 17 modelos de sim y, a partir de sus aportes y limitaciones, establece 4 proposiciones teóricas de base para una concepción general, útiles para la adopción del concepto en la actualidad.
La caída de los precios del petróleo y los salarios de eficiencia en Barrancabermeja – Colombia
Authors: Gutiérrez Mejía Diana Patricia , Nauzan Ceballos Víctor Hugo , Duarte Ballén Brandon Stiven , Galeano Cortés Joan David
Published: June 2018

El presente artículo de reflexión pretende dar cuenta de la posible relación entre la caída de los precios del petróleo y el desempleo inherente a la teoría de salarios de eficiencia, los cuales se pagan en el sector petrolero en Barrancabermeja. Para esto, se parte de la pregunta: ¿Fue la caída de los precios del petróleo o el tipo de salarios pagados en el sector petrolero los que afectaron la economía en Barrancabermeja después de 2014? Para responderla, se realiza un análisis descriptivo apoyado en la investigación realizada en 2017 sobre este tema por Gutiérrez, Nauzan y García, presentando diferentes evidencias sobre las altas tasas de desempleo y los cambios en los precios del petróleo.
PROPHETIC VALUES IN POST-REFORM MODERN JAVANESE NOVELS
Authors: Sulaksono Djoko , Waluyo Budi , Said Dewi Pangestu
Published: June 2018

This study aims to describe the prophetic value in post-reform modern Javanese novels. This was a qualitative study. The analysis technique used is content analysis. The results showed that post-reform modern Javanese novels contain many prophetic value. Nowadays, many societies abandoned the understanding of prophetic values. The character of society has shifted to become more individualistic and only concerned with the welfare of him-self. It’s due to inappropriate outer cultural filtration. People find a difficulty to sort foreign cultures that are compatible with Indonesian characteristics (especially Javanese Moslem). It needs to get a community guidance to return to his nature as an individual, social, and aware of his position as a servant of Allah swt. This research can be used as a medium to educate people about positive values in life. The prophetic values taught are divided into three dimensions: humanization dimension (ammar ma›ruf), liberation (nahi munkar), and transcendence (tu›minu billah). Meanwhile, theoretically this research can enrich the treasury of knowledge in the field of literature, provide input in noble learning through the medium of literature, and it can be used as a basis for more in-depth research. The character of society has changed to become more individualistic and only concerned with the welfare of him-self. Meanwhile, this research also enriches the treasury of knowledge in the field of literature, as an alternative in moral education through literary media, and can be used as a basis for more in-depth research.

Penelitian ini dilaksanakan dengan tujuan mendeskripsikan nilai-nilai profetik dalam novel-novel Jawa modern pascareformasi. Penelitian ini merupakan penelitian kualitatif. Teknik analisis yang digunakan adalah teknik analisis isi. Hasil dari penelitian ini menunjukkan bahwa novel-novel modern pascareformasi banyak mengandung nilai-nilai profetik. Dewasa ini, pemahaman mengenai nilai-nilai profetik banyak ditinggalkan. Karakter masyarakat telah bergeser menjadi lebih individualis dan mementingkan kesejahteraan dunia belaka. Hal ini disebabkan karena filtrasi budaya luar yang kurang maksimal. Masyarakat kurang dapat memilah budaya-budaya yang sesuai dengan karakteristik Indonesia (khususnya muslim Jawa). Perlu adanya upaya pembinaan kepada masyarakat agar kembali kepada fitrahnya sebagai mahluk individu, sosial, dan menyadari posisinya sebagai seorang hamba Allah swt. Penelitian ini dapat digunakan sebagai sarana mendidik masyarakat perihal nilai-nilai positif dalam hidup. Nilai-nilai profetik yang diajarkan terbagi dalam tiga dimensi yaitu dimensi humanisasi (ammar ma’ruf), liberasi (nahi munkar), dan transendensi (tu’minu billah). Sementara itu, secara teoretis penelitian ini dapat memperkaya khazanah pengetahuan pada bidang sastra, memberi masukan dalam pembelajaran aklak mulia melalui media sastra, serta dapat digunakan sebagai landasan penelitian yang lebih dalam lagi.
SERAT CABOLEK, SUFISM BOOK OR IDEOLOGY DOCUMENTS OF JAVANESE PRIYAYI?
Authors: Fauzan Pepen Irpan , Fata Ahmad Khoirul
Published: June 2018

Many researches concern with the dialectic between Islam and tradition of Java. One of them is Soebardi studying Serat Cabolek, a manuscript that illustrated the dialectic between Islam and Javanese tradition in 18/19th century. Through philological studies Soebardi has produced a PhD thesis at The Australia National University (1967), and published in 1975 under title “The Book of Cabolek”. This book should be appreciated for having presented an important study on Islam and Java. Yet, it also needs to be studied more deeply through historical studies in order to obtain clearer information about the context. This article attempts to give a short review about the content of the book, and gives a critical explanation based on its socio-historical perspective. The result is that the story in Serat Cabolek is a construction of Javanese Priyayi on their history. It is an upscale historical document, to strengthen the king’s position as Panatagama.

Dialektika Islam dan tradisi Jawa menarik perhatian banyak peneliti. Salah satunya adalah Soebardi yang mengkaji Serat Cebolek, sebuah naskah yang dianggap menjadi gambaran dialektika Islam-Jawa abad 18/19 M. Melalui kajian filologis Soebardi menghasilkan karya disertasi di Australia National University tahun 1967, dan diterbitkan dengan judul “The Book of Cabolek” pada 1975. Buku ini patut diapresiasi karena telah menyajikan satu teks yang penting bagi studi Islam dan Jawa. Namun juga perlu ditelaah melalui penelusuran sejarah untuk memahami konteksnya agar informasi yang didapat lebih lengkap. Tulisan ini berusaha memberikan ikhtisar tehadap isi buku tersebut dengan disertai penjelasan kritis berdasarkan perspektif sosio-historisnya. Hasil kajian menunjukkan bahwa kisah yang terdapat dalam Serat Cebolek merupakan konstruksi priyayi mengenai realitas sejarah. Serat ini adalah dokumen sejarah sosial kelas atas, sebagai simbol peneguhan kepentingan raja sebagai panatagama.
El pensamiento político maya en el Yucatán del siglo XVI: reflexiones sobre 'can' y 'than', “la plática”, “la palabra”
Authors: Cunill Caroline
Published: June 2018

Si bien en los últimos años se ha adelantado mucho en el análisis de la estructura política maya de las tierras bajas del norte de Yucatán –principales cargos, linajes gobernantes y entidades políticas–, todavía se puede ahondar en la comprensión de los conceptos en que estuvo fundamentado el orden político maya en víspera de la conquista española. A partir del cotejo de distintos textos coloniales tempranos escritos en lengua maya por autoridades autóctonas y de definiciones de voces mayas yucatecas contenidas en uno de los primeros diccionarios coloniales, el Calepino de Motul, el presente trabajo tiene el objetivo de identificar nociones claves en el pensamiento político de los mayas y de acercarse a su propia concepción de la justicia. Se plantea la hipótesis de que la idea de “palabra concertada” fue central en la visión maya del buen gobierno y de la justicia.
Identification of odorant characters using GC-MS/O in biosolids emissions from aerobic and anaerobic stabilisation
Authors: Fisher Ruth M. , Barczak Radoslaw J. , Stuetz Richard M.
Published: June 2018

Malodorous emissions from biosolids limit potential re-use opportunities. Emissions from anaerobically stabilised biosolids have been widely studied. In contrast, emissions from aerobically stabilised biosolids have not been well documented. Individual odorants in complex emissions can be detected using sensorial analysis methods, such as gas chromatography mass spectroscopy coupled with an odour detection port (GC-MS/O) where assessors sniff the GC effluent to identify odorants present. In this study, GC-MS/O was used to study and compare emissions from biosolids produced from aerobically and anaerobically stabilised biosolids from different wastewater treatment plants (WWTPs). The WWTPs varied in size, catchments and dewatering technology. Three GC-MS/O assessors were used for the sensorial analysis. The identified odorants varied significantly between the two sites using aerobic stabilisation, in number of odour characters detected, as well as their intensity. Different odour characters were noted from biosolids generated at the aerobic digestion sites compared to characters from biosolids generated at the anaerobic digestion site. Biosolids from the aerobic digestion sites had medicinal, acrid or putrid type odours not noted from the anaerobic site. However, descriptors of biosolids emissions were commonly noted as: rotten vegetables, seaweed, garbage, garlic, or bad-breath. Many of the descriptors were associated with the presence of sulfur-type compounds. The importance of assessor variability was also highlighted in the paper where certain characters were not detected or were described differently by assessors.
Three-dimensional multi-species mathematical model of the aerobic granulation process based on cellular automata theory
Authors: Zheng Guoqiang , Su Kuizu , Zhang Shuai , Wang Yulan , Wang Weihong
Published: June 2018

Aerobic granular sludge is a kind of microbial polymer formed by self-immobilization under aerobic conditions. It has been widely studied because of its promising application in wastewater treatment. However, the granulation process of aerobic sludge is still a key factor affecting its practical application. In this paper, a three-dimensional (3D) multi-species mathematical model of aerobic granular sludge was constructed using the cellular automata (CA) theory. The growth process of aerobic granular sludge and its spatial distribution of microorganisms were studied under different conditions. The simulation results show that the aerobic granules were smaller under high shear stress and that the autotrophic bacterial content of the granular sludge interior was higher. However, the higher the dissolved oxygen concentration, the larger the size of granular sludge and the higher the content of autotrophic bacteria in the interior of the granular sludge. In addition, inhibition of toxic substances made the aerobic granule size increase more slowly, and the spatial distribution of the autotrophic bacteria and the toxic-substance-degrading bacteria were mainly located in the outer layer, with the heterotrophic bacteria mainly existing in the interior of the granular sludge.
Controle interno na percepção dos gestores: estudo nas fundações de apoio às instituições federais de ensino superior do Brasil
Authors: Oliveira Synara Lia Bezerra de , Marques Maria Aparecida do Nascimento Cavalcanti , Penha Roberto Silva da
Published: June 2018

O terceiro setor é composto por organizações sem fins lucrativos, formado exclusivamente de organizações não governamentais. Nesse segmento se enquadram as fundações de apoio às instituições de ensino, instituições criadas para dar apoio no gerenciamento administrativo e financeiro na execução de projetos de pesquisa, ensino e extensão e de desenvolvimento institucional, científico e tecnológico, e para uma administração eficiente dessas instituições faz-se necessários mecanismos que auxiliem na sua gestão. O presente trabalho tem como objetivo verificar a percepção dos gestores em relação ao controle interno nas fundações de Apoio às Instituições Federais de Ensino Superior do Brasil. Essa pesquisa caracterizou-se como descritiva; para coleta dos dados foi aplicado um questionário com escala Likert às 102 fundações associadas ao Conselho Nacional das Fundações de Apoio às Instituições de Ensino Superior e de Pesquisa Científica e Tecnológica (Confies), para análise dos resultados utilizou-se a métrica do raking médio e a ferramenta de tabela de contingência. Dentre os resultados, vale destacar que 58% das fundações possuem um órgão de controle interno, quanto aos funcionários na percepção dos gestores, estes possuem conhecimento das responsabilidades de forma prática em 92,3%, em contraponto que o conhecimento via manuais de controle interno teve apenas 30,7% de concordância. 84,6% concordam que os procedimentos de controle interno são utilizados para atender obrigações legais. Percebe-se que as instituições possuem noção sobre o que é o controle interno, contudo, as entidades que afirmam possuir esse órgão apresentam falhas nas suas atuações.
Contratos de gestão com organizações sociais: o papel dos sistemas de controle interno como ferramenta de acompanhamento e fiscalização
Authors: Silva Girlando Gomes da , Cruz Vera Lucia , Santos Ramon Rodrigues dos , Leone Rodrigo J.Guerra
Published: June 2018

Este estudo teve como objetivo apresentar os resultados do controle interno do órgão supervisor no acompanhamento e fiscalização dos contratos de gestão. Quanto à metodologia, tomou-se como base o estudo da doutrina, artigos científicos e periódicos sobre a temática, análise de documentos apresentados pelas organizações sociais no período de janeiro a dezembro de 2016 no estado da Paraíba, como: prestações de contas, notas fiscais, contratos de serviços de terceiros, guias de recolhimento de tributos e outras que se fizeram necessárias no decorrer na análise. Foram identificadas 11 (onze) irregularidades na execução dos contratos analisados, como também se indicou as medidas corretivas a serem adotadas, bem como as implicações dessas irregularidades para a continuidade dos contratos. Com base nos dados, foram identificadas diferenças com os estudos de Babatunde e Dandago (2014) e semelhanças com a auditoria realizada por Brasil (2015). Por fim, conclui-se com a pesquisa que os contratos de gestão analisados pelo controle interno do órgão supervisor, denominados de A, B, C e D, apresentaram inconformidades como: despesas insuficientemente comprovadas; despesas com desvio de finalidade; demonstrativos contábeis inconsistentes; ausência de rotinas e procedimentos para controle patrimonial; não observância do princípio da unidade de tesouraria e omissão de registros contábeis
Eficiência e eficácia organizacional em instituições de ensino superior da rede privada brasileira
Authors: Andrade Aline Alves de , Quel Luiz Felipe
Published: June 2018

As mudanças recorrentes na área educacional imputam a associação do binômio qualidade-resultado ao desempenho organizacional, tais como produtividade, lucratividade e competitividade, de forma que diligenciem saber e indicadores de eficiência e eficácia. A partir disso, essa pesquisa objetivou identificar os elementos que definem a eficiência e a eficácia para as esferas estratégicas das instituições de ensino superior da rede privada brasileira, tendo como problema de pesquisa os fatores elencados pelos executivos e demais profissionais com poder de decisão das IES brasileiras que apontam para a constituição da eficiência e eficácia dessas organizações. O referencial teórico apresenta as definições de eficiência e eficácia transitando, inclusive, pelo âmbito educacional. O método foi uma pesquisa empírica de caráter exploratório, centrada em uma abordagem qualitativa e apoiada por metodologia de análise de discurso com técnica de entrevista semiestruturada voltadas a identificar percepção acerca dos “n” fatores de eficiência e eficácia nas decisões estratégicas, tendo como objeto de pesquisa a instituição de ensino superior da rede privada brasileira, representada por organizações da cidade de São Paulo. Como resultado, foi possível identificar que custo, resultado e impacto são fatores de eficiência e eficácia elencados pelos executivos para tomada de decisão, alicerçados pela capacidade de fazer algo da melhor forma possível, fomentando o desenvolvimento institucional e de seus indicadores de qualidade administrativa e acadêmica.
Contrariando os fundamentos de finanças corporativas: análise da destruição de valor na Petrobras a partir de 2010
Authors: Godoi Alexandre Franco de , Santos José Odálio dos
Published: June 2018

Esta pesquisa de abordagem qualitativa é desenvolvida para explorar e entender a destruição de valor ocorrida na Petrobras S.A. – este um dos casos mais intrigantes envolvendo uma empresa de capital aberto no país. Os objetivos da pesquisa, de natureza exploratória, buscam identificar os principais fatores que contribuíram para a expressiva perda de valor de mercado ocorrida na empresa a partir de 2010. Utilizando-se do método de estudo de caso, é possível explicar ainda as variáveis causais preponderantes da destruição de valor promovida na companhia. Os resultados da pesquisa indicam que a Petrobras S.A. esteve submetida nos últimos anos a más decisões estratégicas que contrariaram os fundamentos de finanças corporativas. Além disso, a exposição a riscos sistêmicos e não sistêmicos e problemas de governança corporativa foram outros fatores determinantes para queda no preço das ações da companhia e para sua destruição de valor. Com a empresa no centro de um dos maiores escândalos de corrupção e fraudes envolvendo políticos e empresários deste país, o descrédito no mercado financeiro e o cenário de expectativas futuras pouco otimistas projetado pelos potenciais investidores, foram aspectos adicionais que intensificaram o cenário de destruição de valor e que levaram a perdas financeiras significativas para seus acionistas. Embora algumas medidas estratégicas para recuperação do valor de mercado da companhia venham sendo adotadas pela administração da empresa desde 2015, o interesse pelo tema de destruição de valor em uma das maiores empresas brasileiras de capital aberto merece ser analisado com o devido rigor metodológico pelas pesquisas acadêmicas.
Ponto de equilíbrio contábil na pecuária leiteira de Bubalinos: um estudo de caso da viabilidade econômico financeira Em uma propriedade do estado de Mato Grosso do Sul
Authors: Vieira Eloir Trindade Vasques , Itavo Luis Carlos Vinhas , Aranha Jose Carlos Moura
Published: June 2018

Por meio de abordagem qualitativa, com base em pesquisa exploratória e bibliográfica, foi realizada um estudo de campo em uma propriedade rural localizada no município de Bandeirantes, interior do estado de Mato Grosso do Sul – MS que cria búfalas para produção leiteira. As análises realizadas por meio de entrevistas e de dados coletados possibilitaram conferir características da avaliação econômica da propriedade, apresentando as receitas, os custos e as despesas provenientes desse segmento no ano de 2015, o que até então a propriedade não possuía. Identificaram-se os custos de produção, o custo médio do leite e o ponto de equilíbrio de uma propriedade que trabalha especificamente com bubalinos, sendo um total de 98 matrizes das raças Murrah e Mediterrâneo. Os resultados destacaram a produção necessária em litros de leite de búfalas para se chegar ao ponto de equilíbrio. Sendo necessária a produção de 130.682 litros de leite por ano pelo custo histórico e 92.635 litros de leite/ano pelo valor justo. Por mês, 10.890 litros pelo custo histórico e 7.719 litros pelo valor justo. Por animal/vaca de 3,65 litros pelo custo histórico, e 2,59 litros pelo valor justo. Os valores de custos por litro de leite foram de R$ 1,67, considerando mensuração pelo custo histórico e, R$ 1,45 considerando o método de valor justo. Dessa maneira, os resultados por ambos os métodos apresentaram índices de lucratividade atrativos, superiores à rentabilidade e aos ativos financeiros no mercado financeiro, sendo de 15,12% pelo custo histórico e 26,43% pelo valor Justo, considerando que este último apresentou melhor taxa de atratividade. Com a mensuração apresentada o gestor tem real noção do que ocorre na empresa, inclusive sendo fator de auxílio à gestão futura, confirmando a viabilidade da atividade.
Hybrid Imaging in Evaluation of Abdominal Sarcoidosis
Authors: Milojevic Isidora Grozdic , Sobic-Saranovic Dragana , Petrovic Nebojsa , Beatovic Slobodanka , Tadic Marijana , Artiko Vera M.
Published: June 2018

Objective: To determine the prevalence of abdominal involvement, distribution pattern and evaluate role of hybrid molecular imaging in patients with abdominal sarcoidosis.

Methods:

Between January 2010 and December 2011, 98 patients with chronic sarcoidosis and presence of prolonged symptoms or other findings suggestive of active disease were referred to FDG PET/CT examination. Active disease was found in 82 patients, and they all were screened for the presence of abdominal sarcoidosis on FDG PET/CT. All patients also underwent MDCT and assessment of serum ACE level. Follow up FDG PET/CT examination was done 12.3±5.4 months after the baseline.

Results:

Abdominal sarcoidosis was present in 31/82 patients with active sarcoidosis. FDG uptake was present in: retroperitoneal lymph nodes (77%), liver (26%), spleen (23%), adrenal gland (3%). Majority of patients had more than two locations of disease. Usually thoracic disease was spread into the extrathoracic localizations, while isolated abdominal sarcoidosis was present in 10% of patients. After first FDG PET/CT examination therapy was changed in all patients. Eleven patients came to the follow up examination where SUVmax significantly decreased in the majority of them. Three patients had total remission, three had absence of abdominal disease but discrete findings in thorax and others had less spread disease. ACE levels did not correlate with SUVmax level.

Conclusion:

FDG PET/CT can be a useful tool for detection of abdominal sarcoidosis and in the evaluation of therapy response in these patients. Awareness of the presence of intra-abdominal sarcoidosis is important in order to prevent long-standing unrecognized disease.
Synthesis and Anticonvulsant Activity of α-Amino Acid Amide Derivatives
Authors: Currier Valerie , Molki Maryam , Fryman Katelyn , Rodgers Lacey D. , Crider A. Michael
Published: June 2018

Background:

Epilepsy is a disease of the central nervous system that affects approximately
50 million individuals worldwide. Although several new drugs have been marketed in the last 25 years,
almost one-third of patients are not protected. In many cases, currently available drugs produce undesirable
side effects. As a result, a need exists for novel anticonvulsants with unique mechanisms of action
and minimal side effects.

Methods:

A mixed anhydride coupling procedure and standard deprotection procedures were utilized to
prepare 36 α-amino acid amides. All final products were evaluated in mice and rats utilizing a standard
battery of anticonvulsant tests.

Results:

α-Amino acids containing a 2,6-dimethylanilide group exhibited anticonvulsant activity in the
maximal electroshock seizure test and 6 Hz test in mice and rats. A small, branched-chain on the α-
carbon generally maintained or enhanced anticonvulsant activity in the maximal electroshock seizure
test. The (R)-α-amino acid amides were typically more potent and slightly more neurotoxic than the
corresponding (S)-enantiomers. The valine dimethylanilide (R)-42 was highly active in the MES test in
mice (ED50 = 3.6mg/kg) and rats (ED50 = 3.8 mg/kg). (R)-42 also demonstrated excellent anticonvulsant
activity in the 6 Hz, picrotoxin, and corneal kindled mouse tests. Furthermore, (R)-42 did not lower
seizure threshold when evaluated in the intravenous metrazol seizure test.

Conclusion:

α-Amino acid 2,6-dimethylanilides exhibited potent activity in a variety of anticonvulsant
tests in mice and rats. The valine derivative (R)-42 represents a promising compound for potential use in
complex partial seizures.
Quantification and Evaluation of Glycyrrhizic Acid-loaded Surface Decorated Nanoparticles by UHPLC-MS/MS and used in the Treatment of Cerebral Ischemia
Authors: Ahmad Niyaz , Ahmad Rizwan , Alam Md Aftab , Ahmad Farhan Jalees , Rub Rehan Abdur
Published: June 2018

Background:

Glycyrrhizic Acid (GRA), a potent antioxidant triterpene saponin glycoside
and neuroprotective properties exhibits an important role in the treatment of neurological disorders i.e.
cerebral ischemia. GRA is water soluble, therefore it’s have low bioavailability in the brain.

Objective:

To enhance brain bioavailability for intranasally administered Glycyrrhizic Acidencapsulated-
chitosan-coated-PCL-Nanoparticles (CS-GRA-PCL-NPs).

Methods:

Chitosan-coated-PCL-Nanoparticles (CS-PCL-NPs) were developed through double emulsification-
solvent evaporation technique and further characterized for particle size, zeta potential, size
distribution, encapsulation efficiency as well as in vitro drug release. UPLC triple quadrupole Qtrap
MS/MS method was developed to evaluate brain-drug uptake for optimized CS-GRA-PCL-NPs and to
determine its pharmacokinetic in rat’s brain as well as plasma.

Results:

Mean particles size (231.47±7.82), polydispersity index (PDI) i.e. (0.216±0.030) and entrapment
efficiency (65.69±5.68) was determined for developed NPs. UPLC triple quadrupole Qtrap MS/MS
method study showed a significantly high mucoadhesive potential of CS-GRA-PCL-NPs and least for
conventional and homogenized nanoformulation; elution time for GRA and internal standard (IS) Hydrocortisone
as 0.37 and 1.94 min at m/z 821.49/113.41 and 363.45/121.40 were observed, respectively. Furthermore,
intra and inter-assay (%CV) of 0.49-5.48, %accuracy (90.00-99.09%) as well as a linear dynamic
range (10.00 ng/mL -2000.0 ng/mL), was observed. Pharmacokinetic studies in Wistar rat brain
exhibited a high AUC0-24 alongwith an amplified Cmax (p** < 0.01) as compared to i.v. treated group.

Conclusion:

Intranasal administration of developed CS-coated-GRA-loaded-PCL-NPs enhanced the
drug bioavailability in rat brain along with successfully UPLC-MS/MS method and thus preparation of
GRA-NPs may help treat cerebral ischemia effectively. The toxicity studies performed at the end
revealed safe nature of optimized nanoformulation.
A Facile Synthesis of Cu2O and CuO Nanoparticles Via Sonochemical Assisted Method
Authors: Botsa Sathish Mohan , Dharmasoth Ramadevi , Basavaiah Keloth
Published: June 2018

Background:

During past two decades, functional nanomaterials have received great attention
for many technological applications such as catalysis, energy, environment, medical and sensor
due to their unique properties at nanoscale. However, copper oxide nanoparticles (NPs) such as
CuO and Cu2O have most widely investigated for many potential applications due to their wide
bandgap, high TC, high optical absorption and non-toxic in nature. The physical and chemical properties
of CuO and Cu2O NPs are critically depending on their size, morphology and phase purity.
Therefore, lots of efforts have been done to prepare phase CuO and Cu2O NPs with different morphology
and size.

Method:

The synthesis of cupric oxide (CuO) and cuprous oxide (Cu2O) NPs using copper acetate as
a precursor by varying the reducing agents such as hydrazine sulphate and hydrazine hydrate via
sonochemical method. The phase, morphology and crystalline structure of a prepared CuO and Cu2O
NPs were investigated by X-ray diffraction (XRD), Fourier transform infrared (FTIR), Field emission
scanning electron microscopy (FESEM), Energy dispersive X-ray (EDS) and UV-Visible Diffuse
reflectance spectroscopy (DRS).

Results:

The phase of NPs was tuned as a function of reducing agents.XRD patterns confirmed the
formation of pure phase crystalline CuO and Cu2O NPs. FTIR peak at 621 cm-1 confirmed Cu(I)-O
vibrations, while CuO vibrations confirmed by the presence of two peaks at 536 and 586 cm-1. Further
investigation was done by Raman, which clearly indicates the presence of peaks at 290, 336, 302
cm-1 and 173, 241 cm-1 for CuO and Cu2O NPs, respectively. The FESEM images revealed rod-like
morphology of the CuO NPs while octahedral like shape for Cu2O NPs. The presence of elemental
Cu and O in stoichiometric ratios in EDS spectra confirms the formation of both CuO and Cu2O NPs.

Conclusion:

In summary, CuO and Cu2O NPs were successfully synthesized by a sonochemical
method using copper acetate as a precursor at different reducing agents. The bandgap of CuO and
Cu2O NPs was 2.38 and 1.82, respectively. Furthermore, the phase purity critically depends on reducing
agents.
Processo interativo de formação docente: uma perspectiva emancipatória na constituição do currículo escolar, de Eva Teresinha Boff e José Claúdio Del Pino
Authors: Ravasio Marcele Homrich , Daronco Leandro Jorge
Published: June 2018

.
Knowledge, Attitude, and Practices of Food Handlers on Food Safety and Personal Hygiene During Arbaeenia Mass Gathering, Baghdad, Iraq, 2014: Cross-Sectional Study (Preprint)
Authors: Lami Faris , Radhi Firas , Al Dahhan Safauldeen , Hashim Rana Adel , Mahmood Hussein , Araj Rawan , Arbaji Ali
Published: June 2018

BACKGROUND

Millions of pilgrims attend Arbaeenia mass gathering (MG) in Iraq each year. Thousands of individuals work voluntarily at temporary rest areas (locally called Mawakib), distributed in most of Iraq governorates, to provide food and other services to the MG attendees. The potential for improper handling of food at Mawakib increases the risk of waterborne and foodborne diseases.

OBJECTIVE

This study was aimed to assess the knowledge, attitude, and practices (KAP) of food handlers in Mawakibs in Baghdad city during Arbaeenia MG.

METHODS

A random sample of 100 Mawakibs was selected in Baghdad, 50 from the eastern side (Rusafa) and 50 from the western side (Kerkh), and five food handlers were randomly selected from each Mawakib. A questionnaire was used to collect demographic data and KAP for food safety and personal hygiene. The questionnaire included 25 questions addressing knowledge, 10 addressing attitudes, and 14 addressing practices of the food handlers with respect to food safety and personal hygiene. Questions on knowledge and attitudes were answered through direct interview with the food handlers, whereas the questions on practices were answered through direct observation while handling or serving the food. SPSS version 20 (IBM SPSS Statistics 20) was used for data analysis and describing proportions.

RESULTS

There was a varied knowledge of food safety practices among the individuals interviewed. On a scale of 3, the overall average score for both the attitude and practices for food safety and personal hygiene was 2, which corresponds to fair attitude and practices. The attitudes varied significantly by location, age group, and education, whereas the practices varied by location, age groups, employment, and previous experiences.

CONCLUSIONS

The food handlers had unsatisfactory attitudes and practices toward food handling and personal hygiene. Their participation in food handling at Mawakib carries a potential risk of spreading foodborne and waterborne diseases. All individuals intending to serve in Mawakib as food handlers should be licensed from the Ministry of Health after completing a formal training in food safety and personal hygiene.
Desorption and Re-Adsorption of Procion Red MX-5B Dye on Alumina-Activated Carbon Composite
Authors: Fatma Fatma , Hariani Poedji Loekitowati , Riyanti Fahma , Sepriani Wiwin
Published: June 2018

The alumina-activated carbon has the ability to adsorb and desorb the procion red MX-5B. The research evaluated the influence of desorption agent, contact time, and temperature on desorption process of procion red MX-5B dye with alumina-activated carbon composite and the adsorption capacity of the composite after desorption process. The desorption agents used in desorption process were solution with pH 2−10, H2O2 30 % (v/v), methanol 70% (v/v) and ethanol 70% (v/v). The variation of contact time was in the range from 30 to 270 min and the temperature was set between 30−75 °C. The result concluded that the highest desorption efficiency up to 98.56% was achieved using ethanol 70% (v/v) for 240 min at 45 °C. The desorption kinetic followed the pseudo-first-order with the release constant (kdes) of 6.56 × 10-2 min-1. The SEM micrograph showed there is a more porous surface on the composite after the desorption compared to before the desorption. The EDX analysis indicated that alumina content in the composite was reduced after desorption process. FTIR spectra of the composite before and after desorption process showed a peak of Al−O at 592 and 590 cm-1 which was proved that alumina still exists in the composite after the desorption process. The alumina-activated carbon composite was re-used to adsorb procion red MX-5B dye. After three times of desorption and re-adsorption process, the capacity adsorption was decreased from 12.38 to 7.38 mg/g.
FORMULATION AND EVALUATION OF COMPRESSION COATING FLOATING TABLETS OF CARVEDILOL PHOSPHATE ONCE DAILY DOSE
Authors: Panda Subhranshu , Kumari C. H. Surya , Puniya G.
Published: June 2018

Objective: The rationale for the study was to develop a once-daily dose of immediate as well as a gastro-retentive form of carvedilol phosphate by compression coating floating technique.Methods: In the presented study the core tablet was containing half the quantity of the drug formulated as floating drug delivery using different controlled release polymers blend in various proportions like ethyl cellulose, carbopol, hydroxypropyl methylcellulose (HPMC) K4, K15, and K100 by direct compression method. Outer coat layer was formulated with rest of the drug with the blend of different super disintegrants in various proportions like crospovidone, croscarmellose sodium (CCS), sodium starch glycolate (SSG) for the immediate release of the drug. Both the immediate and controlled formulation was separately formulated from sf1 to sf9 and f1 to f9 respectively. Based on the evaluation parameters finally, formulation F1 to F9 were formulated by applying compression coating floating method. These formulations were characterized for their tablet density, disintegration time, floating lag time, in vitro drug release, drug-excipients interaction and accelerated stability studies etc.Results: The result revealed formulation sf9 containing SSG of 15% was able to 97.2% of drug release within 15 min towards the achievement of immediate release. Similarly, the formulation f9 containing 0.5:0.5:4.5 ratios of ethyl cellulose, carbopol and HPMC K15 was able to 95.3% of drug release within 16h. From compressed coat tablets batches of F1 to F9, based on the dissolution data F9 was considered as an optimized formulation which was able to release 48.6% of drug release within 15 min and cumulatively controlled the release up to 96.4% for 16 h, followed zero-order kinetics and Higuchi pattern.Conclusion: The results obtained in this research work clearly indicated that the compression coating floating tablet of carvedilol phosphate was the best dosage form for the treatment of hypertension. Results of the evaluation of prepared batches indicate that the batch F9 is a promising formulation for both a quick onset of action as well as gastro-retentive dosage form to maintain the constant drug action which would improve the maximum therapeutic efficacy and patient compliance.
LIQUISOLID COMPACTS: AN INNOVATIVE APPROACH FOR DISSOLUTION ENHANCEMENT
Authors: Anil Anjana , Thomas Litha , Sudheer Preethi
Published: June 2018

The challenge faced by the majority of the pharmaceutical products is the poor solubility of the drug candidates which leads to low bioavailability. Liquisolid compact is one of the emerging techniques that enhances the dissolution of poorly water soluble drugs. Liquisolid system mentions to the formulation made by the transforming the liquid drug, either in the form of suspension or solution in non volatile solvents into a dry, non-sticky, free-flowing and compactable powder mixtures. This is achieved by mixing the suspension or solution of the drug with appropriate carriers and coating agents. The technology has the ability to increase aqueous solubility, rate of dissolution and absorption of poorly soluble drug by keeping it in molecularly dispersed form leading to its improved bioavailability when compared to conventional tablets. Liquisolid technology is the impending approach for enhancing the solubility of poorly water-soluble drug by adopting simple manufacturing process and low production cost.