bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest China
Authors: Li Qingqing , Bai Huili , Pan Yan , Liao Yuying , Pei Zhe , Wu Cuilan , Ma Chunxia , Chen Zhongwei , Li Changting , Gong Yu , Liu Jing , Yin Yangyan , Teng Ling , Wang Leping , Zhang Ezhen , Wei Tianchao , Peng Hao
Published: January 2025

The global epidemic of bovine coronavirus (BCoV) has caused enormous economic losses. The characterisation and genetic composition of endemic strains in Southwest China remain elusive. This study aimed to fill this gap by isolating three BCoV strains from this region and sequencing their whole genomes. To elucidate the genetic evolution and characterisation of the prevalent strains, the results of BCoV sequences were compared in GenBank, with a focus on genetic evolution, mutation, and recombination patterns. The results showed close homology between strains NN190313 and NN230328, while strain NN221214 showed less similarity to these two strains but clustered with the French strain of the European branch. Intriguingly, NN190313 and NN230328 were grouped with goat-derived BCoV strains from Jiangsu Province in Eastern China in the Asian–American branch. In addition, recombination analyses revealed significant signals between NN230328 and either a Chinese goat-derived strain (XJCJ2301G) or a Shandong strain (ShX310). This study highlights the importance of monitoring cross-species transmission between cattle and goats, especially in the mountainous areas of Southwest China where mixed farming occurs, and thus, the monitoring of cross-species transmission between cattle and goats is important for preventing new public health challenges, providing important insights for research on cross-species transmission, early prevention, and control measures, with potential applications in vaccine development.
Thoracic Ultrasound in Cattle: Methods, Diagnostics, and Prognostics
Authors: Feitoza Luis F. B. B. , White Brad J. , Larson Robert L.
Published: January 2025

Thoracic ultrasonography (TUS) has emerged as a critical tool in the diagnosis and management of respiratory diseases in cattle, particularly bovine respiratory disease (BRD), which is one of the most economically significant health issues in feedyard operations. The objective of this review is to explore TUS in veterinary medicine, including the historical development, methodologies, and clinical applications for diagnosing and prognosing respiratory diseases. This review also emphasizes the importance of operator training, noting that even novice operators can achieve diagnostic consistency with proper instructions. Ultrasound was introduced in the mid-20th century for back-fat thickness measurements; TUS has evolved to offer a non-invasive, real-time imaging modality that allows for the detection of lung and pleural abnormalities such as consolidations, pleural effusions, and B-lines. These features are vital indicators of respiratory disease, and their early identification through TUS can significantly improve clinical outcomes. Compared to traditional diagnostic methods like auscultation or radiography, TUS provides superior accuracy in detecting both subclinical and advanced respiratory conditions, particularly in high-risk populations. Furthermore, TUS has demonstrated strong prognostic value, with studies showing that the extent of lung consolidation correlates with higher relapse risk, reduced growth performance, and increased mortality.
Application of Geophysical Methods for Hydrogeology
Authors: Sendrós Alex , Cabrera María del Carmen , Casas-Ponsatí Albert
Published: January 2025

Groundwater is considered essential in the world’s current water supply [...]
A Review of Sources, Hazards, and Removal Methods of Microplastics in the Environment
Authors: Meng Xingang , Yuan Juan , Huang Qian , Liu Ruiqi , Yang Yi , Yang Xi , Wang Kaiqi
Published: January 2025

The prevalence of microplastics in a wide range of environmental media has attracted increasing attention worldwide. This review article provides a comprehensive and systematic review of the nature, sources, hazards, and removal methods of microplastics in the environment. In contrast to previous studies focusing on the sources and risks of microplastics in a single environment, this article comprehensively analyses atmospheric, terrestrial runoff, marine and freshwater sources of microplastics and explores the hazards they pose to the environment and the health of humans and other organisms. Microplastics cause multiple adverse effects on aquatic and terrestrial organisms through accumulation, including growth inhibition, oxidative stress, inflammation, organ damage, and germ cell abnormalities. They may also enter the food chain and affect human health. This article summarizes the latest research progress on microplastic removal technologies from biological, physical, and chemical perspectives, with high efficiency, sustainability, and degradability for biological removal and adsorption and filtration being more effective for physical removal. This provides valuable information for future research related to microplastics. We advocate for a reduction in the use of microplastics and provide references for solving the problem of microplastic pollution.
A Journey in Servant-Leadership
Authors: Spears Larry C.
Published: January 2025

A Journey in Servant-Leadership
Preface to Song’s “Persuasion vs. Coercion or Persuasion and Coercion”
Authors: Ferch Shann Ray
Published: January 2025

Preface to Song’s “Persuasion vs. Coercion or Persuasion and Coercion”
Devoted to Healing the Heart of the World
Authors: Ferch Shann Ray
Published: January 2025

Devoted to Healing the Heart of the World
The Practice of Servant-Leadership in Academic Advising
Authors: McClellan Jeffrey L.
Published: January 2025

Servant-leadership and academic advising are closely related concepts. Both are concerned with supporting the growth and development of others through intentional influence processes. While some research has been done to explore the conceptual connections between them, little has been done to identify the specific practices of servant-advisors. This article examines the principles and practices of servant-leadership and offers insight regarding specific practices of servant-leadership that relate to academic advising. These include managing one’s motives, relationship building, compassionate communication, and positive coaching.
Tourism and Recreation Preferences in River Environments:
Authors: Arsyul Salam Dicky , Rahmanda Putra Rifki
Published: January 2025

This study investigates the preference and motviations of Generation Z tourist in river enviromnets, with focul on West Java, Indonesia. Using a structured survey approach targeting 140 respondents, the research findings indicate that recreational motivations and connection with nature are central to visitor satisfaction, complemented by infrastructure quality and tranquility. Statistical analysis revealed strong interconnections between the factors influencing activity choices and the quality of visitor experiences, providing deeper insight into what drives satisfaction in river environments.. The study underscores the potential of river-based tourism to integrate environmental, cultural, and economic objectives while addressing sustainability challenges. Future research should explore longitudinal studies and expanded cultural contexts to further optimize tourism strategies.
Timbers Response to Phelan
Authors: Timbers Veronica
Published: January 2025

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O uso, desuso e o uso inadequado de equipamentos de proteção individual por profissionais de enfermagem em unidades hospitalares
Authors: Almeida Nádia Barboza Santana de
Published: January 2025

O uso de Equipamentos de Proteção Individual (EPIs) é essencial para garantir a segurança e a saúde dos profissionais de enfermagem e dos pacientes em unidades hospitalares. No entanto, o desuso ou uso inadequado desses equipamentos continua sendo uma prática comum, o que gera consequências significativas para a saúde ocupacional e a segurança dos envolvidos. Este estudo tem como objetivo geral analisar as práticas relacionadas ao uso, desuso e uso inadequado de EPIs pelos profissionais de enfermagem em unidades hospitalares. Especificamente, busca-se identificar as causas que levam ao desuso e uso inadequado desses equipamentos, assim como avaliar as repercussões dessas práticas para os profissionais, pacientes e instituições de saúde. A pesquisa questiona: Quais são as consequências para os profissionais de enfermagem e para a qualidade do cuidado prestado, decorrentes do desuso ou uso inadequado de EPIs? A metodologia utilizada foi uma revisão bibliográfica baseada em publicações obtidas nas bases de dados MEDLINE, LILACS, SCIELO, além de artigos completos disponíveis online. Os resultados indicaram duas principais temáticas: Saúde do Trabalhador e Biosegurança, e as vulnerabilidades da equipe de enfermagem no ambiente hospitalar. Conclui-se que o uso correto dos EPIs não apenas protege os trabalhadores e pacientes, mas também promove a conscientização e a reflexão sobre a importância contínua da segurança e saúde no ambiente hospitalar, ressaltando o papel transformador que os profissionais de saúde podem ter em seus locais de trabalho.
Os impactos da pandemia de COVID-19 no desenvolvimento dos estudantes sob perspectiva dos professores do Vale Do Caí – RS
Authors: Roriz João Pedro , Grabowski Gabriel
Published: January 2025

Durante a pandemia, a transição do ensino presencial para o remoto gerou dificuldades de adaptação e resultou em um aumento significativo na evasão escolar, especialmente na rede pública, devido diversos impactos e fatores enfrentados pelas famíliase seus filhos. Esta pesquisa buscou identificar e compreender como os professores de educação do ensino fundamental perceberam as mudanças cognitivas, comportamentais, sociais e psicológicas de seus estudantes no retorno às aulas presenciais em 2022. A abordagem metodológica da pesquisa foi qualitativa e baseou-se na escuta de 12 professores de quatro cidades do Vale do Caí (RS), ou seja, três professores por cidade. A pesquisa destacou que a saúde mental dos estudantes foi afetada, com aumento nas dificuldades emocionais e interação social, gerando ansiedade, depressão e evasão escolar. Os professores, apesar de desempenharem um papel fundamental, enfrentaram a falta de apoio dos gestores públicos, o que prejudicou seu trabalho e protagonismo. Assim, entendemos que para abordar esses desafios, são necessárias estratégias educacionais e de apoio emocional e material, o que inclui investimento em tecnologia educacional acessível e formação continuada para os professores. Reconhecer e valorizar o papel fundamental dos professoresinvestindo condições de trabalho adequadas é crucial para a qualidade da educação e da aprendizagem dos estudantes.
Economia solidária, geração de renda e cuidados em saúde: relato de uma experiência em saúde mental
Authors: Cruz Patrícia Nassif da , Amarante Paulo Duarte de Carvalho , Guljor Ana Paula Freitas
Published: January 2025

Um dos principais instrumentos da reforma psiquiátrica é a potencialização do trabalho como forma de inclusão social de pessoas em sofrimento psíquico e geração de renda e trabalho. A economia solidária (ES) vem se destacando enquanto possibilidade de combate ao estigma da loucura, evidenciando o protagonismo social dos sujeitos por meio da solidariedade, autogestão, cooperação e geração de renda pelo trabalho. Diante disso, o problema da pesquisa foi: como são realizadas as atividades no cotidiano do Programa “Arte, Horta & Cia” – geração de vida e renda (PGRT), desenvolvido no Museu Bispo do Rosário Arte Contemporânea (MBRAC) na cidade do Rio de Janeiro, pelos usuários para ter acesso ao trabalho, renda e cuidados em saúde? Objetiva-se, verificar no contexto da reforma psiquiátrica brasileira, como funcionam os processos de geração de trabalho e renda e o funcionamento cotidiano deste programa à luz dos princípios da ES. Para tanto, procedeu-se à metodologia de pesquisa qualitativa, exploratória, revisão bibliográfica, documental, estudo de caso. O tratamento dos dados a partir da aplicação das entrevistas semiestruturadas foi usada na análise de conteúdo, com base em Bardin na modalidade temática, por meio da categorização dos temas decorrentes das falas dos participantes nas entrevistas. Desse modo, observou-se que a ES é o caminho para inclusão social, geração de renda e cuidados em saúde, o que permite concluir que o PGRT reafirma a capacidade que tem, como mecanismo para o protagonismo social pelo trabalho dos sujeitos em sofrimento psíquico.
Efeitos cardiovasculares do uso indiscriminado de esteroides anabolizantes androgênicos: uma revisão integrativa da literatura
Authors: Júnior Eduardo Abrão , Lima João Felipe Gonçalves de , Xavier Igor Silvestre , Azevedo Thayná Alves de , Silva Rogério Teodoro da , Filho Denis Aguiar de Souza , Soares Nayane Peixoto , Ghazale Poliana Peres
Published: January 2025

O uso indiscriminado de Esteroides Anabolizantes Androgênicos (EAA) tem aumentado significativamente, não apenas entre atletas, mas também em indivíduos que buscam melhorar sua aparência física devido ao paradigma da imposição estética. No entanto, a literatura recente sugere que o uso impróprio dessas substâncias pode acarretar uma série de efeitos adversos, especialmente no sistema cardiovascular. Este estudo tem como objetivo identificar e analisar os efeitos cardiovasculares mais prevalentes advindos do uso indiscriminado de EAA. Trata-se de uma revisão integrativa de literatura realizada a partir das bases de dados Google Acadêmico, Scielo, Biblioteca Virtual em Saúde (BVS) e PubMed, com artigos selecionados de 2019 a 2024. Os critérios de inclusão foram artigos escritos em inglês e português, disponibilizados gratuitamente, sendo excluídos aqueles que não respondiam ao objetivo proposto. A discussão baseou-se em 21 artigos selecionados, os quais tiveram suas informações extraidas e analisadas. Dessa maneira, as consequências cardiovasculares advindas do uso indiscriminado dos anabolizantes podem ser classificadas em eventos diretos e eventos indiretos, como dislipidemia, aterosclerose, disfunção miocárdica, homocisteinemia, coagulopatia, isquemia cardíaca, infarto agudo do miocárdio, doença arterial coronariana, alterações morfológicas, calcificação vascular, cardiomiopatia, hipertensão arterial, e Doença Arterial Coronariana.
Reganho de peso após cirurgia bariátrica: causas, desafios e abordagens terapêuticas
Authors: Guirardelli Laura Perussi , Oliveira Júlia Quemel , Prytulak Leticia Silva , Moretti Lívia Faria , Santos Pedro Henrique Teixeira Marques dos , Florenciano Sara Fernanda , Reis Vinícius Emmerich , Peixoto Fábio Henrique da Silveira
Published: January 2025

Este artigo tem como objetivo revisar as principais causas do reganho de peso após a cirurgia bariátrica e discutir as abordagens terapêuticas disponíveis. A cirurgia bariátrica é uma das intervenções mais eficazes para o tratamento da obesidade severa e suas comorbidades, proporcionando perda de peso significativa e melhora na qualidade de vida. No entanto, o reganho de peso após o procedimento é uma preocupação comum, afetando entre 20% e 30% dos pacientes a longo prazo. O fenômeno é multifatorial, envolvendo aspectos comportamentais, psicológicos, fisiológicos, como adaptações metabólicas e alterações hormonais; e técnicos, relacionados ao tipo de procedimento e possíveis falhas anatômicas. O tratamento exige uma abordagem multidisciplinar, combinando reeducação alimentar, prática de exercícios físicos, suporte psicológico e intervenções farmacológicas. Em casos específicos, revisões cirúrgicas podem ser necessárias. A compreensão aprofundada das causas e o desenvolvimento de estratégias integradas são essenciais para prevenir e tratar o reganho de peso, contribuindo para a sustentabilidade dos resultados pós-bariátricos e a melhoria da saúde dos pacientes.
A Vascularized Multilayer Chip Reveals Shear Stress-Induced Angiogenesis in Diverse Fluid Conditions
Authors: Yue Tao , Yang Huiying , Wang Yue , Jiang Ning , Yin Hongze , Lu Xiaoqi , Liu Na , Xu Yichun
Published: January 2025

Tissues larger than 400 μm in size lacking microvascular networks cannot survive for long periods of time in vitro. The development of microfluidic technology provides an efficient research tool for constructing microvascular models in vitro. However, traditional single-layer microfluidic chips faced the limitation of spatial layout and could not provide diverse fluidic environments within a single chip. In this paper, we present a novel microfluidic chip design with a 3-layer configuration that utilizes a polycarbonate (PC) porous membrane to separate the culture fluid channels from the tissue chambers, featuring flexibly designable multitissue chambers. PC porous membranes act as the capillary in the vertical direction, enabling precise hydrogel patterning and successfully constructing a microfluidic environment suitable for microvascular tissue growth. The chip demonstrates the ability to build microvascular networks of different shapes such as triangle, rectangle, and inverted triangle on a single chip for more than 10 days. The microvascular networks cultured for 12 days were successfully perfused with 70-kDa fluorescein isothiocyanate, which indicated that the generated networks had good barrier properties. A correlation between tissue chamber shape and shear stress was demonstrated using COMSOL, and a preliminary validation of the flow direction of interstitial flow and the important effect of shear stress on microvascular growth was demonstrated by vascularization experiments. This flexible and scalable design is ideal for culturing multiple vascularized organ tissues on a single microfluidic chip, as well as for studying the effects of different fluidic factors on microvascular growth.
Recent Advances in Asymmetric Wettability Dressings for Wound Exudate Management
Authors: Wang Fang , He Wenqing , Dai Bing , Zhang Xueji , Wen Yongqiang
Published: January 2025

The management of wound exudate is of vital importance for wound healing. Exudate accumulation around wound prolongs inflammation and hinders healing. Although traditional dressings can absorb wound exudate, they are unable to drain exudate in time, often resulting in a poor feature with wound healing. In recent years, the appearance of asymmetric wettability dressings has shown great potential in exudate management. Here, we summarize the latest progress of 3 kinds of asymmetric wettability wound dressings in exudate management, including Janus structure, sandwich structure, and gradient structure. The most common Janus structural dressing among asymmetric wettability dressings is highlighted from 2 aspects: single-layer modified Janus structure and double-layer Janus structure. The challenges faced by asymmetric wettability wound dressings are discussed, and the developing trends of smart wound dressings in this field are prospected.
PPID em equinos: abordagem diagnóstica e terapêutica - Relato de caso
Authors: Silva Thayná da Cruz Paduan
Published: January 2025

A disfunção da pars intermédia da hipófise (PPID), ou síndrome de Cushing equina, é uma endocrinopatia progressiva que afeta principalmente equinos geriátricos e é subdiagnosticada no Brasil. Este estudo apresenta o caso de uma égua Mangalarga, de 18 anos, com sinais clínicos de PPID, incluindo emagrecimento progressivo, hirsutismo e letargia, além de alterações metabólicas e sistêmicas. A investigação inicial apontou anemia normocítica e normocrômica, leucocitose com neutrofilia segmentada e indícios de um processo inflamatório. O diagnóstico foi confirmado por meio do teste de supressão com dexametasona. O tratamento incluiu o uso de mesilato de pergolida e medidas de manejo clínico. Após dois meses, observou-se melhora significativa dos parâmetros clínicos e laboratoriais, com redução dos níveis de cortisol para valores normais e melhora do escore corporal. Este relato destaca os desafios no diagnóstico da PPID, especialmente em regiões onde o conhecimento sobre a doença ainda é limitado, e reforça a importância do uso de abordagens terapêuticas integradas. A relevância do caso reside em ampliar a compreensão clínica dessa endocrinopatia e promover a conscientização sobre sua ocorrência e manejo em equinos no Brasil.
Assessement of plasma total protein and protein fractions during peripartum period in ewes
Authors: Haffaf Samia , Djaalab Imene , Zemmouri Laatra , Djaalab-Mansour Hadria
Published: January 2025

The aim of this study was to determine the blood protein changes during different physiological stages and to compare with pregnancy and dairy period in ewes. A total of 120 blood samples were taken from thirty Ouled Djellal ewes (the native sheep breed in Algeria) at the beginning of pregnancy (on 30 days), at the late of pregnancy (on 120 days) and on days 7 and 30 postpartum.
The mean concentrations of total proteins, albumin, globulins (in gram per litre) and urea (in mmol/l were measured. A significant decrease (p<0.05) in total protein, urea, and albumin levels occurred at the 120th day of pregnancy compared to the beginning of pregnancy. While, globulins concentrations were higher (p<0.05) on late pregnancy. It was concluded that blood protein levels declined during late gestation when the nutrient demands of the fetus were maximal. Moreover, the results of the study showed a significant increase (p<0.01) in albumin concentrations during the post partum period. There were however, during this period a significant reduction (p<0.01) in the plasma concentrations of globulins.
Autofagia: mecanismo de sobrevivencia y/o muerte cellular
Authors: Boyer Francehuli Dagger
Published: January 2025

La autofagia es un proceso omnipresente en todos los eucariotas, donde se ha descubierto una maquinaria genética adaptada para diferentes linajes celulares. Han sido descritos varios tipos de autofagia, involucrados en numerosos procesos fisiológicos donde funciona como un mecanismo protector; sin embargo, se ha descrito también que puede actuar en determinadas circunstancias como un mecanismo de muerte celular. En el proceso de diferenciación in vitro de Leishmania mexicana de la forma promastigote a la forma amastigote, hemos reportado un nuevo proceso selectivo parecido a autofagia dirigido a degradar complejos de membrana–microtúbulos redundantes, en respuesta a la elevación de la temperatura y acidificación del medio, imitando así los cambios que sufre el parásito durante la invasión del macrófago. Este proceso de diferenciación es importante para la sobrevivencia del parásito dentro del macrófago y la virulencia. Puede ser un modelo útil para estudiar el efecto de drogas dirigidas a bloquear la diferenciación y sobrevivencia del parásito, como nueva estrategia para combatir la enfermedad.
Qualidade da água das praias do Farol e Paraíso, ilha de Mosqueiro, Belém/PA
Authors: Baldez Matheus Vieira , Melo Emile Louise de Sousa , Monteiro Mateus Henrique de Jesus , Plautz Junior Hélio Longoni , Ribeiro Karla Tereza Silva , Ribeiro Sheyla Mara de Almeida
Published: January 2025

As praias são importantes áreas de recreação, sendo necessário avaliar a qualidade das águas desses locais, para que possam assegurar a saúde dos banhistas. Assim, este estudo objetivou analisar as condições de balneabilidade das praias do Farol e Paraíso, ilha de Mosqueiro, Belém/PA. As praias foram divididas em três pontos de amostragem, nos quais foram realizadas análises físico-químicas e microbiológicas. Os resultados físico-químicos demonstraram alteração apenas nos parâmetros de oxigênio dissolvido, estando os demais parâmetros dentro dos padrões estabelecidos pela legislação. A análise microbiológica mostrou valores elevados de coliformes termotolerantes no terceiro ponto da praia do Farol, o qual foi considerado impróprio para banho. Os demais pontos estavam de acordo com os padrões estabelecidos pela legislação e foram considerados próprios para banho. A praia do Paraíso foi considerada de excelente qualidade, provavelmente por ser uma praia mais afastada do centro urbano, o que diminui os riscos de contaminação pelas atividades antrópicas. Já a praia do Farol é bastante frequentada, ficando mais sujeita a impactos ambientais. Por isso, é necessário que haja um monitoramento e planejamento sanitários desses locais, com a finalidade de prevenir doenças de veiculação hídrica, de forma que assegure o uso dessas importantes áreas de recreação e garanta a saúde pública e ambiental.
PENGARUH KEPEMIMPINAN MANDOR DAN PEKERJA (TUKANG DAN KENEK) TERHADAP KESELAMATAN DAN KESEHATAN KERJA (K3) PADA RUSUN PONPES AL MUSLIMUN BENGKULU TENGAH
Authors: Rewa Rewa Arbi Wicaksono
Published: January 2025

Kumpulan kontruksi yang melaksanakan tugas sesuai dengan bidangnya masing-masing. Dipimpin oleh seorang kepala yang mengatur semua kegiatan yang dijalankan oleh setiap pekerja. Peran ketua dalam pekerjaan ini menjadi seseorang yang berdampak pada anggotanya. Untuk itu setiap ketua harus selalu mematuhi atturan yang telah dibuat dan bertanggungjawab penuh pada para anggotanya. Bukan hanya itu, seorang ketua juga harus mengutamakan keselamatan dan Kesehatan kerja (K3) agar sebuah pekerjaan bisa berjalan sesuai dengan target yang telah ditetapkan. Tujuan dilakukannya penelitian ini agar dapat mengetahui dampak seorang ketua tentang aturan yang dibuat pada pembangunan Rusun Ponpes Al-muslimun Bengkulu Tengah. Untuk informasi diperoleh melalui penyebaran berbagai pertanyaan diberikan kepada informan yang bekerja. Untuk sampel diperoleh menggunakan cara non- probability sampling (purposive). Untuk reesponden yang akan digunakan yaitu 50 orang pekerja melalui terjun langsung ke objek penelitian. Kemudian melalui cara regresi linear berganda agar bisa menghasilkan data menggunakan Y 22,109 + 0,144X1 – 0,104X2, menjelaskan bahwa (X1) dan (X2) memberikan dampak pada (Y) sebesar 0,000 0,050 dan nilai Adjusted R Square sebesar 0,692 atau 69,2 % yang dipengaruhi dari variabel (X1) dan (X2) terhadap variabel (Y). Setelah melakukan penelitian bahwa ketua dan aturan yang dibuat akan memberikan dampak pada keselamtanan dan kesehatan kerja (K3).Kata Kunci:Kepemimpinan, Kedisplinan, K3
REDESIGN STRUKTUR GEDUNG TATA USAHA TOWER PUSDIKLAT PENGAWASAN BPKP CIAWI BOGOR
Authors: Nugraha Wiratna Tri , Anindhita Shopia Putri
Published: January 2025

Redesign Struktur Gedung Tata Usaha Tower Pusdiklat Pengawasan BPKP Ciawi, Bogor dengan Sistem Rangka Pemikul Momen Khusus (SRPMK). Gedung ini memiliki 10 lantai dilengkapi lift room dan machine room dengan tinggi bangunan 42,95 m, tinggi lantai dasar 3,6 m. Mutu beton yang digukana f’c 45 MPa serta mutu baja tulangan fy 420 MPa. Dari hasil analisa dan perhitungan struktur diperoleh dimensi balok induk BI 400/650 mm dengan tulangan tumpuan atas 6D22, bawah 5D22, tulangan torsi 4D13, sengkang 4D10-100 dan tulangan lapangan atas 3D22, bawah 3D22, tulangan torsi 2D13, sengkang 3D1-100 serta selimut beton 40 cm. Dimensi balok induk BI 250/450 mm dengan tulangan tumpuan atas 3D19, bawah 3D19, sengkang 2D10-150 dan tulangan lapangan atas 2D19, bawah 2D19, sengkang 2D-150 serta selimut beton 40 cm. Dimensi kolom K1 yaitu 700/700 mm dengn dengan konfigurasi 16D22, 800/800 mm dengn dengan konfigurasi 20D22, 850/850 mm dengn dengan konfigurasi 24D22. Dimensi pada Hubungan Balok Kolom mencukupi dan dipasangan sengkang 6D13-100. Dimensi pelat tangga dan bordes tumpuan D13-150 dan lapangan D13-150. . Dimensi pelat lantai tumpuan D10-200 dan lapangan D10-200. Dimensi pelat atap tumpuan ?8-150 dan lapangan ?8-200 Sedangkan dimensi balok tangga yaitu 250/400 dengan tulangan tumpuan dan lapangan sama yaitu tulangan atas 4D13, bawah 3D13 serta sengkang 2D10-150. Dimensi balok penggantung lift yaitu 250/400 dengan tulangan tumpuan dan lapangan sama yaitu tulangan atas 5D13, bawah 4D13 serta sengkang 2D10-150.  Kata Kunci:Perencanaan Struktur Atas, Sistem Rangka Pemikul Momen, Struktur Tahan Gempa
ANALISIS KUALITAS KONTEN MEDIA SOSIAL TERHADAP KEPUTUSAN PEMBELIAN STUDI KASUS PADA INSTAGRAM OLIVIA INGES
Authors: Larasati Alifa Azanisa , Selva Selva , Hafis Abdul
Published: January 2025

Saat ini penggunaan internet dan sosial media untuk berbagai keperluan telah merambat kepada pengguna individu maupun ke segala industri. Tujuan Dari Penelitian Ini Adalah Kualitas Konten Media Sosial TerhadapKeputusan Pembelian  Studi Kasus Pada Instagram Olivia Inges. Metode penelitian yang digunakan adalah kualitatif  deskriptif dan mengumpulkan data melalui wawancara dan observasi dengan terjun langsung ke lapangan menemui informan. Hasil Penelitian menunjukkan Nilai konten Instagram Olivia Inges berkualitas standar karna kurangnya membangun interaksi kepada calon pelanggan/pelanggan dan juga konten yang dibuatnya terlihat biasa saja sehingga calon pelanggan/pelanggan menjadi bosan dan kurang tertarik lagi untuk melihatnya. Hal itu bisa menghambat dalam mempengaruhi keputusan pembelian.Dalam memberikan informasi, konten Olivia Inges belum optimal karena terdapat beberapa konten Instagram yang diposting tidak menerangkan informasi harga produk/barang. Kemudian keterbacaan dalam postingan kontennya kurang jelas dan tidak konsisten, karena terdapat 2 atau 3 model dalam satu postingan konten tanpa keterangan yang menjelaskan satu per satu produk/barang tersebut, ini akan membuat calon pelanggan/pelanggan menjadi bingung dan dapat mempengaruhi prilaku konsumen dalam memutuskan pembelian, ciri khas konten Olivia Inges yaitu sederhana dan aesthetic, konten yang diposting seperti foto dan video yang hanya ditambahkan music trend pada saat itu, namun dari awal berdiri akun Instagram Olivia Inges hingga kini belum ada pembaharuan konten yang dibuat Olivia Inges masih sama saja semuanya, sehingga beberapa pelanggan yang telah lama mengikuti Olivia Inges menjadi bosan dan kurang tertarik lagi melihat postingan konten Olivia Inges, oleh karena itu akan mempengaruhi dalam keputusan pembelian kedepannya
STRATEGI PENGEMBANGAN BISNIS MENGGUNAKAN PENDEKATAN BMC DAN ANALISIS SWOT DALAM UPAYA MENINGKATKAN DAYA SAING (STUDI KASUS PADA CV KEMBAR PROMOSI)
Authors: Dwijayati Gita Nofieka
Published: January 2025

Industri manufaktur masih menjadi pendorong utama perekonomian nasional di Indonesia. Hal ini tercermin dari konsistensi industri pengolahan non migas yang memberikan kontribusi paling besar terhadap PDB (Produk Domestik Bruto) nasional yang dapat mencapai pertumbuhan sebesar 16,30 persen pada triwulan II tahun 2023. Perkembangan industri manufaktur juga ditandai dengan meningkatnya kebutuhan masyarakat terhadap produk-produk hasil industri manufaktur yang sangat beragam dan telah menjadi kebutuhan hampir di semua bidang kehidupan sehari-hari. Persaingan bisnis dalam bisnis manufaktur saat ini semakin ketat, oleh karena itu, perusahaan membutuhkan strategi agar dapat tetap bertahan atau unggul dalam persaingan, termasuk CV Kembar Promosi. CV Kembar Promosi merupakan salah satu UMKM di Kota Cianjur yang bergerak di bidang manufaktur aksesoris yaitu produk tali lanyard. Perusahaan ini berdiri pada tahun 2022. Sebagai perusahaan yang relatif baru CV Kembar Promosi dihadapkan pada persaingan yang cukup tinggi karena semakin banyaknya penjual produk yang sejenis Penelitian ini bertujuan untuk menganalisis pengembangan strategi bisnis dengan menggunakan pendekatan BMC (Business Model Canvas) dan analisis SWOT yaitu IFAS, EFAS, dan Matriks SWOT. Penelitian ini menggunakan metode deskriptif kualitatif dengan teknik pengambilan data melalui observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bisnis berada di kuadran I yang berarti mengarah pada “Growth Oriented Strategy” yaitu mendukung strategi agresif yang kemudian hasil ini menjadi masukan untuk perbaikan Business Model Canvas. Dari implementasinya, terlihat bahwa perbaikan direkomendasikan pada kesembilan elemen Business Model Canvas, dengan strategi yang dihasilkan menjadi masukan bagi pihak manajemen
ANALISIS SALURAN DAN EFISIENSI PEMASARAN JAGUNG DI KECAMATAN PUJUT KABUPATEN LOMBOK TENGAH
Authors: Septiadi Dudi
Published: January 2025

Investigasi rantai pemasaran komoditas pertanian merupakan isu krusial bagi transparansi keuntungan yang diperoleh pelaku dalam sistem agribisnis, khususnya dalam sistem agribisnis jagung. Tujuan penelitian ini adalah untuk; 1) Menganalisis saluran pemasaran jagung di Kecamatan Pujut Kabupaten Lombok Tengah; 2) Menganalisis efisiensi pemasaran jagung di Kecamatan Pujut Kabupaten Lombok Tengah; Penelitian dilakukan di Desa Mertak, Kecamatan Pujut, Kabupaten Lombok Tengah.  Penelitian ini dilakukan menggunakan metode kualitatif-deskriptif. Teknik pengambilan data menggunakan wawancara dengan responden yang dipandu dengan kuesioner terhadap lembaga pemasaran. Responden petani jagung yang menjual hasil panen kepada lembaga pemasaran sebanyak 44 responden jagung yang ditentukan dengan pendekatan rumus dari Slovin. Sedangkan responden lembaga pemasaran ditentukan secara snow-ball sampling. Analisis data yang digunakan adalah analisis saluran pemasaran dan analisis efisiensi pemasaran menggunakan pendekatan marjin pemasaran, farmer share dan distribusi keuntungan. Hasil menunjukkan terdapat 4 saluran pemasaran. Saluran pemasaran I dinyatakan sebagai saluran yang paling efisien dibanding 3 saluran lainnya, baik dari segi marjin pemasaran, farmer's share, maupun distribusi keuntungan. Hal ini menunjukkan penjualan langsung dari petani ke pedagang antar daerah (PAD) merupakan saluran yang paling menguntungkan bagi petani jagung. Hanya saja akses informasi dan transportasi yang dimiliki petani relatif terbatas untuk menjalankan skema saluran I.
Implementasi Jaringan Dengan Load Balancing Dengan Metode Pcc Dan Recursive Route Failover Mikrotik
Authors: Kristanto Lian , Raharjo Mugi
Published: January 2025

Untuk Seiring dengan semakin majunya teknologi dibidang telekomunikasi maka pelayanan terhadap masyarakat juga sudah berbasis online, seperti halnya yang terjadi di kantor cabang PT. Pelni. Namun, terkadang pelayanan terhambat dikarenakan gangguan koneksi internet yang tiba-tiba terganggu, maka dengan menggunakan system failover dibantu dengan modem yang berfungsi sebagai ISP 2 yang merupakan solusi dalam membackup koneksi internet dari ISP 1 apabila mengalami offline secara tiba-tiba. Pada penelitian ini kami melakukan analisis penlitian dengan metode teknik pengumpulan data dan analisa penelitian yang dilakukan pada PT. Pelayaran Nasional Indonesia. Pada penelitian ini seluruh client dan user yang terkoneksi ke ISP 1 akan diarahkan ke ISP 2 menggunakan sistem failover dan hasilnya seluruh client atau user dapat terbackup dengan baik dan juga kita lakukan load balancing digunakan untuk mendistribusikan beban lalu lintas jaringan secara merata pada dua jalur koneksi, sehingga kinerja internet menjadi lebih seimbang dan stabil. MikroTik berperan dalam menandai paket data yang mengakses internet dan menentukan jalur ISP yang akan digunakan, serta mendistribusikan beban pada kedua ISP. Dengan diterapkannya implementasi ini menjadikan jairngan di PT.Pelayaran Nasional Indonesia mendjadi optimal dan realtime selama 24 jam bisa terjamin penggunaan jaringan internetnya secara optimal
Smart Tax – The Concept of Gamification, Board Game & Metaverse Inside Tax Profiling To Make Taxpayers Comfortable
Authors: Novianto Sendi , Gamayanto Indra , Sundjaja Arta Moro , Mailangkay Adele B L
Published: January 2025

Tax is one of the essential pillars in the development of a country, where taxes can have a positive impact on changing people's lives. This research will focus on how gamification, board games, and metaverse can increase the ease of paying taxes, create a more effective and efficient organizational structure to generate business for state financial institutions, implement tax incentives appropriately, and provide fair solutions for taxpayers. Convenience for the community is an essential focus in this research because it is a fundamental thing that must be built and implemented so that when paying taxes, people feel that it is no longer an obligation but a lifestyle. Furthermore, applying technology such as gamification, board games, and metaverse will improve services to the community. Several concepts, such as building a business in a financial institution, will generate profits for the country. Finally, after these things can be implemented, institutions can provide right-on-target incentives to the community that really should get them, including incentives that fall into the correct category. The results of this study are a framework for compiling a smart tax profile (level of maturity in compiling a tax profile) that combines all types of incentives to be used as essential guidelines and applied in the long term. In this conceptual research, gamification is a link with taxpayers to make it more interesting and increase positive bonds; board games are game boards that are useful for carrying out manual simulations by sitting together and discussing, while metaverse and AI can be used for tax simulations so that taxpayers can understand more deeply about taxes.
CHEMICAL AND ORGANOLEPTIC QUALITY CHARACTERISTIC OF SNACK BARS WITH THE ADDITION CONCENTRATION OF SOYBEAN PULP (Glycine max L.) AND MARGARINE
Authors: Yudo Wandoko Sungkowo , Kurnia Hartati Fadjar , Handarini Kejora
Published: January 2025

Snack bar is a ready-to-eat product in the form of  bar that contains good nutrients for the body which if viewed functionally can be used as emergency food consumption. Soybean pulp (Glycine max L.) contains high nutrients that are 28.36% protein, 7.6% crude fiber, and 5.52% fat. Margarine can be used to make processed products tender. The purpose of this study was to determine the effect and what is the concentration of the addition soybean pulp flour and margarine that produces the best chemical and organoleptic quality of snack bars. This research method uses laboratory experimental methods and Complete Randomized Design (RAL) research design with the addition of soybean pulp concentration (20%, 30%, 40%, 50%) and margarine (40%, 30%, 20%, 10%). Based on the results of fingerprint analysis (ANSIRA) using statistical product and service solution (SPSS), the addition of different concentrations of soybean pulp flour and margarine has a significant effect on the water content and protein content of snack bars, has a very real effect on fat content, fiber content, taste, color, and tenderness of snack bars, and there is no real effect on the aroma of snack bars. The determination the best results using the effectiveness test showed that snack bar treatment (T2M2) was the best treatment with  yield value (NH) of 0.61% with parameter criteria were protein content of 17.43%, crude fiber content of 4.37%, fat content of 30.83%, crude fiber content of 4.37%, taste 4.1 (like), tenderness 4 (like), color 4 (like), and smell 4 (like).
KARAKTERISTIK ORGANOLEPTIK COOKIES DENGAN PENAMBAHAN BAHAN BAKU BUAH LABU MADU DAN TEPUNG DAUN KELOR
Authors: Yuliani Yuliani , Syamsiah Melissa , Rizki Fauzi Muhammad
Published: January 2025

Cookies merupakan makanan ringan yang digemari semua orang, terutama anak anak, dibutuhkan inovasi baru untuk membuat cookies yang lebih bergizi dengan menggunakan buah dan sayuran. Cookies dengan penambahan buah labu madu dan tepung daun kelor diharapkan memiliki kandungan gizi yang tinggi, menjadikannya makanan selingan yang lebih baik untuk anak anak yang menderita stunting, serta dapat memenuhi kebutuhan energi, protein, lemak, dan zat besi pada anak anak. Tujuan penelitian ini untuk mengetahui pengaruh penambahan buah labu madu dan tepung daun kelor terhadap karakteristik organoleptik supaya menjadi olahan yang dapat digemari oleh semua kalangan, dilaksanakan di Laboratorium Fakultas Sains Terapan Universitas Suryakancana Cianjur, dengan waktu pelaksanaan pada bulam Maret 2024. Data diolah menggunakan metode RSM (Response Surface Method) dengan 28 panelis biasa dan 2 orang panelis ahli dengan parameter uji yang dilakukan yakni meliputi tekstur, warna, aroma dan rasa. Masing-masing panelis diberikan 5 sampel berbeda pada setiap formulasinya. Hasil terbaik dengan nilai rata-rata pada parameter rasa (6,20), aroma (5,96), tekstur (5,76) dan warna (6,36), diperoleh pada formulasi F3, dengan penambahan buah labu madu 40% tepung daun kelor 0%.
The Influence of Image on Staycation Intention at Dusun Bambu Ecolodge
Authors: Humaira Cyrilla Pratania , Novianti Syifaa
Published: January 2025

The image of a destination significantly impacts tourists' experiences and intentions, particularly in the hospitality and tourism industry. This study examines how the image of Dusun Bambu Ecolodge influences tourists' intention to engage in staycations. Using a quantitative approach, data were collected through questionnaires distributed to 105 respondents who had experienced a staycation at the ecolodge. The analysis employed descriptive and verification statistical techniques, including simple linear regression. The findings reveal that image positively and significantly influences staycation intention, with a correlation coefficient of 0.662 and a determination coefficient of 41%. This indicates that the image variable can explain 41% of the variation in staycation intention, while other factors influence the rest. These results underscore the importance of maintaining and enhancing a positive image to boost staycation intentions. The study highlights practical strategies, including optimizing digital marketing and leveraging social media to promote engaging content and positive visitor experiences. This research contributes to understanding how destination image drives tourist behaviour, offering valuable insights for ecolodge operators and stakeholders in the sustainable tourism sector.
Sustainability and Environmental Care: Social Responsibility
Authors: Lira-Mejía María Carmen , Landeros-Guerra Martha Soledad , Villegas-Torres María del Sagrario , Ortiz-Rayas Ana María
Published: January 2025

The climate crisis is worsening as greenhouse gas emissions continue to increase; the availability of drinking water for the population; “Day 0” makes it more present; you practice it in agriculture and other economic activities; As the growth of the national population increases in urban areas where water conditions are overexploited, all of this compromises the availability of natural resources for future generations. The challenge we face to transform environmental conditions with individual activities is not impossible, political leaders and public institutions should unite all stakeholders to focus on the SDGs to strengthen collaboration, while building trust and accountability. In search of actions that make course, government institutions at state and federal level has the Legislative Strategy for the 2030 Agenda, the awareness of citizens in the state of Guanajuato and in the municipalities was given the installation and implementation of the Bodies for Monitoring and Implementation of the 2030 Agenda (OSI), clear actions, now is not the time for analysis and diagnosis, we must be aware respectful with us and with future generations.
Immunoinflammatory Reponse In Periodontal Disease
Authors: Wagh Dr. Bharti T , M. Asrani Dr. Diksha , S. Jadhav Dr. Shalaka
Published: January 2025

The body has developed defense mechanisms to
control and to cope up with the constant attack of
microorganisms. Host response to the bacterial
challenge presented by subgingival plaque is the
most important determinant of disease severity. Periodontitis is multifactorial infectious disease of
the supporting structures of the teeth, characterized
by destruction of the bone and connective tissue.
Specific periodontopathic bacteria and their
virulence factors are the primary etiologic agents.
However, interaction of host defense mechanisms
and these etiological agents plays an important role
in the onset and progression of the disease
Formulation and Evaluation of Amoxicillin Oral Tablets for Suspension for Pediatric Patients
Authors: saha Dr Nansri
Published: January 2025

The formulation and evaluation of amoxicillin oral
tablets for suspension aimed at pediatric patients
involves the development of an innovative dosage
form that ensures ease of administration, accurate
dosing, and improved therapeutic efficacy.
Amoxicillin, a broad-spectrum antibiotic, is
commonly used to treat bacterial infections in
children; however, pediatric patients often face
difficulties with swallowing conventional tablets.
The primary objective of this study was to design
and evaluate an oral tablet that can be reconstituted
into a suspension for easier administration in
younger patients. Various excipients were selected
for their suitability in tablet formulation,
considering factors like stability, taste-masking,
and ease of dispersion in water. The formulation
was designed to allow easy reconstitution into a
stable suspension. Key factors evaluated included
the physical characteristics (hardness, friability,
disintegration time), chemical stability (amoxicillin
content), and in vitro release profile of the tablets.
The suspension's pH, viscosity, and microbial
stability were also assessed to ensure safety and
efficacy. Results indicated that the optimized
formulation of amoxicillin oral tablets for
suspension met the required quality standards,
demonstrating appropriate reconstitution
properties, acceptable taste masking, and stable
drug release. The formulation was also shown to be
safe for pediatric use, with minimal side effects and
high patient compliance. This study demonstrates
the potential of reconstitutable tablet formulations
as a reliable dosage form for pediatric patients,
providing an alternative to liquid suspensions while
maintaining the therapeutic benefits of amoxicillin
Determination of Mesalamine in Human Plasma by using Ultra Performance Liquid Chromatography – Mass Spectrometry/ Mass Spectrometry
Authors: Sumithra M Sumithra M , Aanandhi M. Vijey , Abinaya J Abinaya J
Published: January 2025

AIM: To develop and validate Mesalamine in
human plasma for bio availability and bio
equivalence studies by using LC-MS/MS.
MATERIALS AND METHODS: The
Mesalamine D3 as internal solution (IS).
Separation was achieved by liquid-liquid extraction
on Phenomenex Luna 5u, C18 (150 mm x 4.6 mm).
The mixture of Acetonitrile: 0.1% Formic Acid
(60:40), v/v is used as a mobile phase 1.2 ml/min
with splitter 50% flow will go inside used as a flow
rate.
RESULTS: Ulcerative colitis is an idiopathic
inflammatory colon disease that causes widespread
friability and superficial erosions on the colonic
wall, as well as bleeding. Mesalamine, a 5-
aminosalicylic acid molecule (5-aminosalicylate, or
5-ASA), is the most often prescribed treatment for
mild to severe ulcerative colitis. Around 80% of NAc-5-ASA is bound to plasma proteins, while 40%
of mesalamine is protein bound. Mesalamine is an
aminosalicylate with an atomic load of 153.1g/mol.
CONCLUSION: The calibration curve is linear
and plotted. The developed method is accurate,
precise, sensitive method for determination of
mesalamine from human plasma solution. The
reported method is suitable for bioequivalence and
pharmacokinetic studies.