bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study of a Specialised American Police Discourse Genre: Probable Cause Affidavits
Authors: Cartron Audrey
Published: November 2023

This paper focuses on the analysis of a specialised American police discourse genre and is based on a corpus of 115 probable cause affidavits. A probable cause affidavit is a sworn statement written by American police officers to state that there is probable cause to believe the defendant has committed (or is committing) a criminal offence and that legal action is required. After briefly presenting the methodological framework for this study, the paper intends to show how the police use specific linguistic, discursive and rhetorical strategies to serve a specialised purpose, which is to present the existence of probable cause to the relevant legal authorities. The findings indicate that officers use various discursive devices to inform but also—and perhaps more importantly—to convince their audience by means of a chronological and structured narrative of events that follows a prototypical three-fold internal organisation (exposition, investigation, resolution) signalled by specific linguistic markers. Finally, the paper intends to go beyond the objective description of events in order to highlight the assertive nature of this discourse genre and the additional rhetorical strategies used by PCA writers. It studies the emphasis placed on the expertise of the author, as well as the police classification of the offence and the progressive elaboration of the burden of proof.
Titanium-Dioxide-Nanoparticle-Embedded Polyelectrolyte Multilayer as an Osteoconductive and Antimicrobial Surface Coating
Authors: Rothpan Matthew , Chandra Teja Dadi Nitin , McKay Geoffrey , Tanzer Michael , Nguyen Dao , Hart Adam , Tabrizian Maryam
Published: November 2023

Bioactive surface coatings have retained the attention of researchers and physicians due to their versatility and range of applications in orthopedics, particularly in infection prevention. Antibacterial metal nanoparticles (mNPs) are a promising therapeutic, with vast application opportunities on orthopedic implants. The current research aimed to construct a polyelectrolyte multilayer on a highly porous titanium implant using alternating thin film coatings of chitosan and alginate via the layer-by-layer (LbL) self-assembly technique, along with the incorporation of silver nanoparticles (AgNPs) or titanium dioxide nanoparticles (TiO2NPs), for antibacterial and osteoconductive activity. These mNPs were characterized for their physicochemical properties using quartz crystal microgravimetry with a dissipation system, nanoparticle tracking analysis, scanning electron microscopy, and atomic force microscopy. Their cytotoxicity and osteogenic differentiation capabilities were assessed using AlamarBlue and alkaline phosphatase (ALP) activity assays, respectively. The antibiofilm efficacy of the mNPs was tested against Staphylococcus aureus. The LbL polyelectrolyte coating was successfully applied to the porous titanium substrate. A dose-dependent relationship between nanoparticle concentration and ALP as well as antibacterial effects was observed. TiO2NP samples were also less cytotoxic than their AgNP counterparts, although similarly antimicrobial. Together, these data serve as a proof-of-concept for a novel coating approach for orthopedic implants with antimicrobial and osteoconductive properties.
Inspection of Spot Welded Joints with the Use of the Ultrasonic Surface Wave
Authors: Ulbrich Dariusz , Psuj Grzegorz , Wypych Artur , Bartkowski Dariusz , Bartkowska Aneta , Stachowiak Arkadiusz , Kowalczyk Jakub
Published: November 2023

Spot welded joints play a crucial role in the construction of modern automobiles, serving as a vital method for enhancing the structural integrity, strength, and durability of the vehicle body. Taking into account spot welding process in automotive bodies, numerous defects can arise, such as insufficient weld nugget diameter. It may have evident influence on vehicle operation or even contribute to accidents on the road. Hence, there is a need for non-invasive methods that allow to assess the quality of the spot welds without compromising their structural integrity and characteristics. Thus, this study describes a novel method for assessing spot welded joints using ultrasound technology. The usage of ultrasonic surface waves is the main component of the proposed advancement. The study employed ultrasonic transducers operating at a frequency of 10 MHz and a specially designed setup for testing various spot welded samples. The parameters of the spot welding procedure and the size of the weld nugget caused differences in the ultrasonic surface waveforms that were recorded during experiments. One of the indicators of weld quality was the amplitude of the ultrasonic pulse. For low quality spot welds, the amplitude amounted to around 25% of the maximum value when using single-sided transducers. Conversely, for high-quality welds an amplitude of 90% was achieved. Depending on the size of the weld nugget, a larger or smaller amount of wave energy is transferred, which results in a smaller or larger amplitude of the ultrasonic pulse. Comparable results were obtained when employing transducers on both sides of the tested joint, as an amplitude ranging from 13% for inferior welds to 97% for superior ones was observed. This research confirmed the feasibility of employing surface waves to assess the diameter of the weld nugget accurately.
Interaction Mechanism between Slags and Alkali Silicate Activators: An Approach Based on the Al Phases
Authors: Jin Yu , Feng Weipeng , Zheng Dapeng , Dong Zhijun
Published: November 2023

In this study, we examined the early-stage interaction of three types of slag and six activators with different chemical compositions. To determine the degree of hydration (DOH) and hydrate assemblage in alkali-activated slag (AAS), we employed EDX, XRD, and NMR analyses. We found that with increasing silicate concentration in the activator, the DOH in the AAS varied, whereas the proportion of C-(N)-A-S-H increased and the other Al-containing phase decreased. When examining the impact of the activator on glass dissolution, it is apparent that an index based on the degree of depolymerization of the glass structure correlates with the DOH and the proportion of hydrotalcite in the AAS. Coupled with the activator’s modulus, this index can be utilised to elucidate the dissolution–reprecipitation mechanism that governs the interaction between the activator and slag.
Superiorization with a Projected Subgradient Algorithm on the Solution Sets of Common Fixed Point Problems
Authors: Zaslavski Alexander J.
Published: November 2023

In this work, we investigate a minimization problem with a convex objective function on a domain, which is the solution set of a common fixed point problem with a finite family of nonexpansive mappings. Our algorithm is a combination of a projected subgradient algorithm and string-averaging projection method with variable strings and variable weights. This algorithm generates a sequence of iterates which are approximate solutions of the corresponding fixed point problem. Additionally, either this sequence also has a minimizing subsequence for our optimization problem or the sequence is strictly Fejer monotone regarding the approximate solution set of the common fixed point problem.
A Mechanistic Model for Long COVID Dynamics
Authors: Derrick Jacob , Patterson Ben , Bai Jie , Wang Jin
Published: November 2023

Long COVID, a long-lasting disorder following an acute infection of COVID-19, represents a significant public health burden at present. In this paper, we propose a new mechanistic model based on differential equations to investigate the population dynamics of long COVID. By connecting long COVID with acute infection at the population level, our modeling framework emphasizes the interplay between COVID-19 transmission, vaccination, and long COVID dynamics. We conducted a detailed mathematical analysis of the model. We also validated the model using numerical simulation with real data from the US state of Tennessee and the UK.
Tolerated Re-Challenge of Immunotherapy in a Patient with ICI Associated Myocarditis: A Case Report and Literature Review
Authors: Shalata Walid , Attal Zoé Gabrielle , Shhadi Rajeh , Abu Salman Amjad , Abu Jama Ashraf , Shalata Sondos , Halumi Kais , Yakobson Alexander
Published: November 2023

Many different types of cancer can be treated with immunotherapy drugs called immune checkpoint inhibitors (ICIs). These drugs have altered the landscape of cancer treatment options since they function by triggering a stronger immune response to malignancy. As expected, ICIs’ modification of immune regulatory controls leads to a wide range of organ/gland-specific immune-related side effects. These adverse effects are uncommonly deadly and typically improve by discontinuing treatment or administering corticosteroid drugs. As a result of a number of factors—including a lack of specificity in the clinical presentation, the possibility of overlap with other cardiovascular and general medical illnesses, difficulties in diagnosis, and a general lack of awareness—the true incidence of ICI-associated myocarditis is likely underestimated. Currently, protocols for the surveillance, diagnosis, or treatment of this condition are unclear. Several questions remain unanswered, such as how to best screen for this rare toxin, what tests should be run on patients who are suspected of having it, how to treat myocarditis once it has developed, and who is at most risk. In this article, we provide a case study of ICI-associated myocarditis and explain its key characteristics and treatment options.
The Microstructural Refinement of the A356 Alloy Using Semi-Solid and Severe Plastic-Deformation Processing
Authors: Gebril Mohamed Abdelgawad , Omar Mohd Zaidi , Mohamed Intan Fadhlina , Othman Norinsan Kamil , Aziz Ahmad Muhammad , Irfan Osama M.
Published: November 2023

Improving the engineering properties of A356 alloy is an appealing option for the automotive industry. This study aimed at refining and redistributing Si particles and the eutectic phase by applying T6 heat treatment to a semi-solid A356 alloy, followed by severe plastic deformation (SPD). Using a cooling-slope technique, the as-cast and rheocast samples were subjected to heat treatment prior to being processed using equal-channel angular pressing (ECAP) and high-pressure torsion (HPT) at room temperature. The results show that the brittle Si particles were effectively fragmented and redistributed in the homogenous microstructure. The grain size reduced from 170 μm to 23 μm in the as-cast sample after combining heat treatment and the cooling-slope. This was followed by the ECAP sample after six passes through route A (where the sample is not rotated between each pass), while it reduced to 160 nm after five turns of the HPT process in a heat-treated cooling-slope sample. The hardness of the heat-treated cooling-slope casting samples increased with the ECAP process; there was an increase from 61 HV to 134 HV for the as-cast alloy after six passes through route A. The hardness of the heat-treated cooling-slope sample improved with the HPT process to 211 HV after five turns.
Analysis of 4-Hydroxyphenyllactic Acid and Other Diagnostically Important Metabolites of α-Amino Acids in Human Blood Serum Using a Validated and Sensitive Ultra-High-Pressure Liquid Chromatography-Tandem Mass Spectrometry Method
Authors: Sobolev Pavel D. , Burnakova Natalia A. , Beloborodova Natalia V. , Revelsky Alexander I. , Pautova Alisa K.
Published: November 2023

The profile of and dynamic concentration changes in tyrosine, phenylalanine, and tryptophan metabolites in blood are of great interest since they could be considered potential biomarkers of different disorders. Some aromatic metabolites, such as 4-hydroxyphenyllactic, 4-hydroxyphenylacetic, phenyllactic, and 4-hydroxybenzoic acids have previously demonstrated their diagnostic significance in critically ill patients and patients with post-COVID-19 syndrome. In this study, a sensitive method, including serum protein precipitation with methanol and ultra-high-pressure liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) detection, was developed and validated for six phenyl- and five indole-containing acids in human serum. The liquid–liquid extraction was also examined, but it demonstrated unsatisfactory results based on analyte recoveries and the matrix effect. However, the recoveries for all analytes reached 100% and matrix effects were not observed using protein precipitation. This made it possible to use deionized water as a blank matrix. The lower limits of quantitation (LLOQs) were from 0.02 to 0.25 μmol/L. The validated method was used for the analysis of serum samples of healthy volunteers (n = 48) to reveal the reference values of the target analytes. The concentrations of the most clinically significant metabolite 4-hydroxyphenyllactic acid, which were revealed using UPLC-MS/MS and a previously developed gas chromatography-mass spectrometry method, were completely comparable. The proposed UPLC-MS/MS protocol can be used in the routine clinical practice of medical centers.
Copper Complexes with N,N,N-Tridentate Quinolinyl Anilido-Imine Ligands: Synthesis and Their Catalytic Application in Chan−Lam Reactions
Authors: Zhou Xiaoyu , Yang Jiaxin , Hao Zhiqiang , Han Zhangang , Lin Jin , Lu Guo-Liang
Published: November 2023

The treatment of 2-(ArNC(H))C6H4-HNC9H6N with n-BuLi and the subsequent addition of CuCl2 afforded the anilido-aldimine Cu(II) complexes 1-5 Cu[{2-[ArN=C(H)]C6H4}N(8-C9H6N)]Cl (Ar = 2,6-iPr2C6H3 (1), 2,4,6-(CH3)3C6H2 (2), 4-OCH3C6H4 (3), 4-BrC6H4 (4), 4-ClC6H4 (5)), respectively. All the copper complexes were fully characterized by IR, EPR and HR-MS spectra. The X-ray diffraction analysis reveals that 2 and 4 are mononuclear complexes, and the Cu atom is sitting in a slightly square-planar geometry. These Cu(II) complexes have exhibited excellent catalytic activity in the Chan–Lam coupling reactions of benzimidazole derivatives with arylboronic acids, achieving the highest yields of up to 96%.
Cloning and Functional Characterization of NADPH-Cytochrome P450 Reductases in Aconitum vilmorinianum
Authors: Cheng Jingping , Li Guodong , Wang Xue , Yang Congwei , Xu Furong , Qian Zigang , Ma Xiaohui
Published: November 2023

Diterpenoid alkaloids (DAs) are major pharmacologically active ingredients of Aconitum vilmorinianum, an important medicinal plant. Cytochrome P450 monooxygenases (P450s) are involved in the DA biosynthetic pathway, and the electron transfer reaction of NADPH-cytochrome P450 reductase (CPR) with P450 is the rate-limiting step of the P450 redox reaction. Here, we identified and characterized two homologs of CPR from Aconitum vilmorinianum. The open reading frames of AvCPR1 and AvCPR2 were found to be 2103 and 2100 bp, encoding 700 and 699 amino acid residues, respectively. Phylogenetic analysis characterized both AvCPR1 and AvCPR2 as class II CPRs. Cytochrome c and ferricyanide could be reduced with the recombinant proteins of AvCPR1 and AvCPR2. Both AvCPR1 and AvCPR2 were expressed in the roots, stems, leaves, and flowers of A. vilmorinianum. The expression levels of AvCPR1 and AvCPR2 were significantly increased in response to methyl jasmonate (MeJA) treatment. The yeasts co-expressing AvCPR1/AvCPR2/SmCPR1 and CYP76AH1 all produced ferruginol, indicating that AvCPR1 and AvCPR2 can transfer electrons to CYP76AH1 in the same manner as SmCPR1. Docking analysis confirmed the experimentally deduced functional activities of AvCPR1 and AvCPR2 for FMN, FAD, and NADPH. The functional characterization of AvCPRs will be helpful in disclosing molecular mechanisms relating to the biosynthesis of diterpene alkaloids in A. vilmorinianum.
Adsorption of Chromium and Nickel Ions on Commercial Activated Carbon—An Analysis of Adsorption Kinetics and Statics
Authors: Lach Joanna , Okoniewska Ewa
Published: November 2023

The adsorption of nickel Ni(II) and chromium Cr(III) ions on the commercial activated carbons WG-12, F-300 and ROW 08, which differ in their pore structure and the chemical nature of their surfaces, were analyzed. The nickel ions Ni2+ were best adsorbed on the WG-12 activated carbon, which had the largest number of carboxyl and lactone groups on the surface of the activated carbons, and the largest specific surface area. Chromium, occurring in solutions with pH = 6 in the form of Cr(OH)2+ and Cr(OH)2+ cations, was best adsorbed on the ROW 08 Supra activated carbon, which is characterized by the highest values of water extract. The precipitation of chromium hydroxide in the pores of the activated carbon was the mechanism responsible for the high adsorption of Cr(III) on this carbon. For the other sorbents, the amount of carboxyl and lactone groups determined the amount of Cr(III) and Ni(II) adsorption. The adsorption kinetics results were described with PFO, PSO, Elovich and intraparticle diffusion models. The highest correlation coefficients for both the Cr(III) and Ni(II) ions were obtained using the PSO model. Among the seven adsorption isotherm models, very high R2 values were obtained for the Toth, Temkin, Langmuir and Jovanovic models. The Cr(III) ions were removed in slightly larger quantities than the Ni(II) ions. The capacities of the monolayer qm (calculated from the Langmuir isotherm) ranged from 55.85 to 63.48 mg/g for the Cr(III), and from 40.29 to 51.70 mg/g for the Ni(II) ions (pH = 6). The adsorption efficiency of Cr(III) and Ni(II) cations from natural waters with different degrees of mineralization (spring, weakly and moderately mineralized) was only a few percent lower than that from deionized water.
Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers
Authors: Yang Wei , Wang Wenping , Cai Song , Li Peng , Zhang Die , Ning Jinhua , Ke Jin , Hou Anguo , Chen Linyun , Ma Yunshu , Jin Wenbin
Published: November 2023

Malignant cardiac arrhythmias with high morbidity and mortality have posed a significant threat to our human health. Scutellarein, a metabolite of Scutellarin which is isolated from Scutellaria altissima L., presents excellent therapeutic effects on cardiovascular diseases and could further be metabolized into methylated forms. A series of 22 new scutellarein derivatives with hydroxyl-substitution based on the scutellarin metabolite in vivo was designed, synthesized via the conjugation of the scutellarein scaffold with pharmacophores of FDA-approved antiarrhythmic medications and evaluated for their antiarrhythmic activity through the analyzation of the rat number of arrhythmia recovery, corresponding to the recovery time and maintenance time in the rat model of barium chloride-induced arrhythmia, as well as the cumulative dosage of aconitine required to induce VP, VT, VF and CA in the rat model of aconitine-induced arrhythmia. All designed compounds could shorten the time of the arrhythmia continuum induced by barium chloride, indicating that 4′-hydroxy substituents of scutellarein had rapid-onset antiarrhythmic effects. In addition, nearly all of the compounds could normalize the HR, RR, QRS, QT and QTc interval, as well as the P/T waves’ amplitude. The most promising compound 10e showed the best antiarrhythmic activity with long-term efficacy and extremely low cytotoxicity, better than the positive control scutellarein. This result was also approved by the computational docking simulation. Most importantly, patch clamp measurements on Nav1.5 and Cav1.2 channels indicated that compound 10e was able to reduce the INa and ICa in a concentration-dependent manner and left-shifted the inactivation curve of Nav1.5. Taken together, all compounds were considered to be antiarrhythmic. Compound 10e even showed no proarrhythmic effect and could be classified as Ib Vaughan Williams antiarrhythmic agents. What is more, compound 10e did not block the hERG potassium channel which highly associated with cardiotoxicity.
Improved Separation in Horizontal Protein SDS-PAGE with Double-Deck Flat Electrodes and a Field Inversion Gel Electrophoresis Module
Authors: Lim Dong Woo , Yoon Tae-Sung , Han Kyung Ho , Sajjad Saba , Shin Heung-Seon , Kang Sunghyun
Published: November 2023

The horizontal flatbed electrophoresis method is employed to separate protein samples, providing greater flexibility for various electrophoretic applications and easier sample loading compared to its vertical counterpart. In the currently available equipment setup, cathode and anode electrodes are positioned on top of a gel at each end. Since an electric field enters the gel from the top, its strength gradually weakens from the top to the bottom of the gel. When examining the interior of gels following electrophoretic separation, the uneven electric field causes the protein bands to lie down forward in the direction of migration, leading to an increase in bandwidth. This issue has remained unaddressed for several decades. To address this problem, new clamp-shaped and double-deck electrodes were developed to apply an electric field simultaneously from both the top and bottom of the gel. Both of these new electrodes facilitated the formation of perpendicular protein band shapes and enhanced resolution at a comparable level. Due to their ease of use, double-deck electrodes are recommended. By combining these new electrodes with the field inversion gel electrophoresis (FIGE) technique, the protein bands could be focused and aligned nearly vertically, resulting in the highest level of electrophoretic resolution. Our electrodes are compatible with polyacrylamide gels of varying sizes, buffer systems, and sample well formats. They can be easily manufactured and seamlessly integrated into existing laboratory instruments for practical use.
In Vivo Evaluation of a Gastro-Resistant Enprotect® Capsule under Postprandial Conditions
Authors: Grimm Michael , Rump Adrian , Kromrey Marie-Luise , Morof Felix , Dumont Camille , Jannin Vincent , Tzvetkov Mladen Vassilev , Weitschies Werner
Published: November 2023

Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness against postprandial intake needed to be proven. In this study, the capsules were administered to 16 healthy young subjects after intake of a light meal. The Enprotect® capsules were labelled with 5 mg black iron oxide and 25 mg 13C3-caffeine. Magnetic Resonance Imaging was used to identify the localization and visual dispersion of the capsule filling. The salivary appearance of caffeine was considered a second independent and sensitive marker for the initial release. Whereas the fasted gastric residence time of the capsules amounted to 43 ± 32 min, it was increased to 158 ± 36 min after postprandial intake. Therefore, the mean dispersion time according to MRI and the mean caffeine appearance time were increased to 196 ± 37 min and 189 ± 37 min, respectively. But, similar to fasted administration, no capsule disintegration or leakage was observed in the stomach and 38% of the capsules disintegrated in the jejunum and 62% in the ileum. The mean dispersion time after gastric emptying and the mean caffeine appearance time after gastric emptying amounted to 38 ± 21 min and 31 ± 17 min, respectively. Both did not relevantly change compared to the fasted intake. Only the absolute dispersion time and caffeine appearance were prolonged due to the increased gastric residence and no relevant influence of the light meal was observed on the disintegration or release behavior of Enprotect® capsules after gastric emptying. The capsules also showed robust enteric properties after postprandial administration.
Rapid and Widespread Distribution of Intranasal Small Extracellular Vesicles Derived from Mesenchymal Stem Cells throughout the Brain Potentially via the Perivascular Pathway
Authors: Shen Weiwei , You Tongyao , Xu Wenqing , Xie Yanan , Wang Yingzhe , Cui Mei
Published: November 2023

Intranasal administration is a promising strategy to enhance the delivery of the sEVsomes-based drug delivery system to the central nervous system (CNS). This study aimed to explore central distributive characteristics of mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) and underlying pathways. Here, we observed that intranasal MSC-sEVs were rapidly distributed to various brain regions, especially in the subcortex distant from the olfactory bulb, and were absorbed by multiple cells residing in these regions. We captured earlier transportation of intranasal MSC-sEVs into the perivascular space and found an increase in cerebrospinal fluid influx after intranasal administration, particularly in subcortical structures of anterior brain regions where intranasal sEVs were distributed more significantly. These results suggest that the perivascular pathway may underlie the rapid and widespread central delivery kinetics of intranasal MSC-sEVs and support the potential of the intranasal route to deliver MSC-sEVs to the brain for CNS therapy.
Physiologically Based Pharmacokinetics Modeling in the Neonatal Population—Current Advances, Challenges, and Opportunities
Authors: Dinh Jean , Johnson Trevor N. , Grimstein Manuela , Lewis Tamorah
Published: November 2023

Physiologically based pharmacokinetic (PBPK) modeling is an approach to predicting drug pharmacokinetics, using knowledge of the human physiology involved and drug physiochemical properties. This approach is useful when predicting drug pharmacokinetics in under-studied populations, such as pediatrics. PBPK modeling is a particularly important tool for dose optimization for the neonatal population, given that clinical trials rarely include this patient population. However, important knowledge gaps exist for neonates, resulting in uncertainty with the model predictions. This review aims to outline the sources of variability that should be considered with developing a neonatal PBPK model, the data that are currently available for the neonatal ontogeny, and lastly to highlight the data gaps where further research would be needed.
An Optical Micro/Nano Fiber Sensor for Monitoring Respiration
Authors: Chen Tuo , Song Yuxia , Zhang Shiya , Li Mingyu
Published: November 2023

In the field of clinical medicine, the real-time monitoring of carbon dioxide (CO2) gas exhaled by the human body is of great significance. At present, the detection devices on the market mainly work by sucking a small amount of gas from the nasal cavity into the detection device, and they present some problems such as overly long sampling tubes, easy blockage or distortion, and an abnormal gas dispersion. In this paper, a micro/nano optical fiber sensor that can directly detect respiration is proposed and is characterized by the relative change in CO2 concentration. The measurement is achieved by using the principle of high evanescent field absorption, and the operating band is 2.004 μm. The sensing effects of micro/nano fibers with different diameters are compared, and the experiment proves that a micro/nano fiber with a diameter of 1 μm can be measured. The light intensity change over 30 s was measured, and the breathing rate was 10–11 times/min. The sensor can achieve a rapid real-time response to CO2 gas detection and is small in size, low-cost, and easy to replace. It has a great application potential in clinical scenarios such as in gastrointestinal endoscopes that require real-time monitoring of human respiration.
Mesoscale Modeling of Polymer Concrete Dynamic Properties
Authors: Dunaj Paweł
Published: November 2023

There is a constant need to predict the dynamic properties of composite materials already at the design stage. A particularly attractive tool for achieving this goal is mesoscale finite element modeling. This paper presents the mesoscale modeling of the dynamic properties of polymer concrete. The method is based on finite element modeling and substructural identification. Substructural identification is a model updating technique based on frequency response functions. It enables the identification of model dynamic properties considering damping. The presented method is used to model the dynamic properties of a polymer concrete beam. In the first step, the mesoscale finite element model is built and then it is decoupled into substructures: a polymer matrix, aggregates, and an interfacial transition zone (ITZ). Next, the dynamic properties of the polymer matrix substructure are updated, and the model is reassembled. Then, second-stage updating takes place, which consists of determining the parameters of the aggregates and the ITZ. The use of substructural identification made it possible to determine the parameters of substructures that do not exist in an independent, isolated form like the ITZ. Moreover, it allows for determining the amount of damping that ITZ brings to the structure.
Asphaltenes from Heavy Crude Oil as Ultraviolet Stabilizers against Polypropylene Aging
Authors: Melekhina Viktoria Y. , Vlasova Anna V. , Ilyin Sergey O.
Published: November 2023

The destruction of polymers under the influence of ultraviolet (UV) radiation is the cause of their aging and deterioration of strength properties. Asphaltenes are low-value waste products after the refining and deasphalting of heavy crude oil, which absorb UV radiation well. Asphaltenes require rational utilization, which suggests their use as UV stabilizing agents for polymers. In this work, asphaltenes were used to prevent UV aging of polypropylene (PP) by adding them in a mass fraction from 5% to 30% within an asphaltene/PP composite material. Rheometry, calorimetry, X-ray diffraction analysis, and tensile strength of PP films containing asphaltenes were performed before and after their intense UV irradiation for accelerated aging. Asphaltenes slightly reduce the viscosity, crystallinity, and mechanical strength of the initial PP due to their plasticizing effect. However, this deterioration in properties is more than compensated when studying UV-aged samples. Intense UV aging causes multiple catastrophic drops in the viscosity and strength of pure PP with the preservation of crystallinity due to the break of polymer chains and a decrease in molecular weight by approximately eight times. Asphaltenes suppress the destruction of PP, which is expressed in a significantly smaller decline in its viscosity and strength due to UV aging. The most optimal content of asphaltenes is 20%, which suppresses UV destruction by six times and best preserves the strength properties of PP.
Electrospun SnO2/WO3 Heterostructure Nanocomposite Fiber for Enhanced Acetone Vapor Detection
Authors: Lin Ting-Han , Chang Yin-Hsuan , Hsieh Ting-Hung , Huang Yu-Ching , Wu Ming-Chung
Published: November 2023

Volatile organic compounds (VOCs), often invisible but potentially harmful, are prevalent in industrial and laboratory settings, posing health risks. Detecting VOCs in real-time with high sensitivity and low detection limits is crucial for human health and safety. The optical sensor, utilizing the gasochromic properties of sensing materials, offers a promising way of achieving rapid responses in ambient environments. In this study, we investigated the heterostructure of SnO2/WO3 nanoparticles and employed it as the primary detection component. Using the electrospinning technique, we fabricated a sensing fiber containing Ag NPs, poly(methyl methacrylate) (PMMA), and SnO2/WO3 (PMMA-Ag-SnO2/WO3) for acetone vapor detection. Following activation via UV/ozone treatment, we observed charge migration between WO3 and SnO2, resulting in a substantial generation of superoxide radicals on SnO2 nanoparticles. This phenomenon facilitates structural deformation of the fiber and alters the oxidation state of tungsten ions, ultimately leading to a significant change in extinction when exposed to acetone vapor. As a result, PMMA-Ag-SnO2/WO3 fiber achieves a detection limit of 100 ppm and a response time of 1.0 min for acetone detection. These findings represent an advancement in the development of sensitive and selective VOC sensing devices.
Fundamentals or Icing on Top of the Cake? A Narrative Review of Recovery Strategies and Devices for Athletes
Authors: Driller Matthew , Leabeater Alana
Published: November 2023

The sport and athletic performance industry has seen a plethora of new recovery devices and technologies over recent years, and it has become somewhat difficult for athletes, coaches, and practitioners to navigate the efficacy of such devices or whether they are even required at all. With the increase in recovery devices and tools, it has also become commonplace for athletes to overlook more traditional, well-established recovery strategies. In this narrative review, we discuss recovery strategies in relation to the hierarchy of scientific evidence, classifying them based on the strength of the evidence, ranging from meta-analyses through to case studies and reports. We report that foam rolling, compression garments, cryotherapy, photobiomodulation, hydrotherapy, and active recovery have a high level of positive evidence for improved recovery outcomes, while sauna, recovery boots/sleeves, occlusion cuffs, and massage guns currently have a lower level of evidence and mixed results for their efficacy. Finally, we provide guidance for practitioners when deciding on recovery strategies to use with athletes during different phases of the season.
Saccharide-Derived Zinc Oxide Nanoparticles with High Photocatalytic Activity for Water Decontamination and Sanitation
Authors: Sultana Kazi Afroza , Hernandez Ortega Javier , Islam Md Tariqul , Dorado Zayra N. , Alvarado-Tenorio Bonifacio , Galindo-Esquivel Ignacio Rene , Noveron Juan C.
Published: November 2023

Zinc oxide nanoparticles (ZnO NPs) with a high photocatalytic performance were prepared by using the aerobic combustion of saccharides such as glucose, fructose, dextrin, and starch with zinc nitrate. The ZnO NPs were characterized by using transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray scattering spectroscopy (EDX), X-ray powder diffraction (XRPD), and UV-vis spectroscopy. The TEM images revealed that the ZnO NPs have sizes ranging from ~20 to 35 nm with a bandgap of ~3.32 eV. The XRPD pattern revealed the hexagonal wurtzite crystalline structure of the ZnO NPs. The photocatalytic properties of the ZnO NPs were studied by the photocatalytic degradation of methyl orange (MO) in deionized water (DIW) and simulated fresh drinking water (FDW) under ultraviolet light (UV-B) and sunlight illumination. The terephthalic acid photoluminescence technique was also used to study the generation of a hydroxyl radical (•OH) by ZnO NPs. The saccharide-derived ZnO NPs exhibited higher photocatalytic activity than the nonsaccharide-derived ZnO NPs. Varying the type of saccharides used during the calcination had some effect on the degree of the catalytic enhancement.
Evaluation of Process Indicators and Challenges of the Elimination of Mother-to-Child Transmission of HIV, Syphilis, and Hepatitis B in Bali Province, Indonesia (2019–2022): A Mixed Methods Study
Authors: Armini Luh Nik , Setiawati Elsa Pudji , Arisanti Nita , Hilmanto Dany
Published: November 2023

Background: This study was conducted to describe the prevalence of and evaluate the processes and challenges in implementing the elimination of HIV, syphilis, and hepatitis B transmission from mother to child in Bali Province, Indonesia. Methods: The research method used is a descriptive approach using indicators and a set of processes by the WHO, quantitative methods using descriptive analysis, and qualitative methods using phenomenological paradigms through in-depth interviews and FGD with healthcare professionals involved in the elimination of mother-to-child transmission (EMTCT) program. Results: The indicators that have successfully met the target for 4 years are antiretroviral therapy (ART) coverage in Badung District (≥95%) and ANC coverage (at least one visit) in Buleleng District (≥95%). The study found low prevalence rates of HIV, syphilis, and hepatitis B among pregnant women in the three districts. There are some indicators that show improvement from 2019 to 2022, namely, syphilis (60.44% to 86.98%) and hepatitis B (29.03% to 95.35%) screening coverage showed improvements, with increasing screening rates observed in Buleleng District. However, adequate treatment coverage for pregnant women with syphilis decreased in Denpasar City in 2022 compared to 2019 (100% to 71.28%). Despite data on hepatitis B treatment being unavailable, hepatitis B vaccination coverage exceeded the WHO target in all three districts. The utilization of the information system is not yet optimal, and there is a lack of ability to track cases. Furthermore, there is insufficient involvement of the private sector, particularly in screening, and a lack of standardized procedures in the management of referrals for pregnant women with hepatitis B. Conclusion: The prevalence of HIV, syphilis, and hepatitis B among pregnant women has consistently remained below the Ministry of Health’s target for four years. Despite this, there are a lot of targets, and the indicator EMTCT process has yet to reach the WHO target. The challenges for each district in reaching the WHO target include providing syphilis and hepatitis B reagents and benzatine penicillin; increasing private sector involvement; and strengthening information systems, policies, and guidelines for the management of hepatitis B among pregnant women in line with WHO recommendations to achieve EMTCT.
Design of a Fuel Cell/Battery Hybrid Power System for a Micro Vehicle: Sizing Design and Hydrogen Storage Evaluation
Authors: Aslam Zayd , Felix Adrian , Kalyvas Christos , Chizari Mahmoud
Published: November 2023

This work focuses on the design of a hybrid proton exchange membrane fuel cell (PEMFC) solution for any micro vehicle such as an unmanned aerial vehicle (UAV). A hydrogen fuel cell can provide extended operation, low emissions, and a highly efficient form of energy storage compared with alternative methods, while a battery can be used as an additional energy storage system to support the transient and higher loads required by the UAV, which are not suitable for normal fuel cell operation. The choice of hydrogen storage is one of the main challenges in using hydrogen as an energy carrier. The current study discusses a range of hydrogen storage technologies and provides a methodology for selection for a given application. A sizing design methodology for a hybrid fuel cell system is proposed. Then, it is applied to a case study to demonstrate its implementation.
Spatial and Temporal Variation Characteristics of Stable Isotopes in Precipitation and Their Relationships with Meteorological Factors in the Shiyang River Basin in China
Authors: Lan Xin , Jia Wenxiong , Zhu Guofeng , Zhang Yue , Yu Zhijie , Luo Huifang
Published: November 2023

Stable isotopes of precipitation play an important role in understanding hydrological and climatic processes of arid inland river basins. In order to better understand the difference of regional water cycle and precipitation patterns, precipitation samples were collected in Shiyang River Basin from June 2018 to May 2020, and spatial and temporal variation characteristics of stable isotopes in precipitation and their relationships with meteorological factors were discussed. The results showed that stable isotopes in precipitation showed seasonal variation characteristics, that δ2H and δ18O values were higher in summer and autumn and lower in winter and spring, and d-excess values were higher in spring and autumn and lower in winter and summer. Slopes and intercepts of the local meteoric water lines gradually increased with elevation increasing. δ18O significantly showed a positive correlation with temperature but a negative correlation with precipitation in summer. Contrary to below 15 hPa, δ18O significantly showed a negative correlation with water vapor pressure above 15 hPa. Due to the influence of meteorological factors, there are significant differences in stable isotopes of precipitation in arid inland river basins, which were more influenced by local moisture recycling in upstream area but by below-cloud secondary evaporation in mid-downstream area.
Susceptibility of Iberia to Extreme Precipitation and Aridity: A New High-Resolution Analysis over an Extended Historical Period
Authors: Claro André M. , Fonseca André , Fraga Helder , Santos João A.
Published: November 2023

The susceptibility to precipitation extreme events (PEEs) and aridity in the Iberian Peninsula (IP) were assessed over a long historical period (1950–2022). Eight extreme precipitation and two aridity indices were calculated. Furthermore, two newly developed composite and principal component-based susceptibility indices were applied. For this purpose, we applied a quantile mapping bias correction of the ERA5-Land reanalysis using the Iberia01 observational dataset in their overlapping period (1971–2015). A trend analysis for 1950–2022 revealed an annual and seasonal drying over the southwestern, central, and northeastern regions, accompanied by annual wetting over the southeast. The PEE contribution to the total precipitation, which was higher over the eastern IP (24 to 28%), increased in several coastal regions during winter, and in the north-central regions during summer and annually. High to very high susceptibility areas, corresponding to ~50% of the IP, were located on the mountains’ Atlantic/Mediterranean-facing side, whereas the inner plateaus revealed a low to moderate susceptibility. Apart from agreeing with previous studies, our results showed with high detail the susceptibility to PEEs and the recent past trends for all the IP regions, which is a novelty among similar studies and allows for improvements in e.g., crop management, urban planning, or risk mitigation.
A Finite Volume Method for a 2D Dam-Break Simulation on a Wet Bed Using a Modified HLLC Scheme
Authors: Salamttalab Mohammad Milad , Parmas Behnam , Mustafa Alee Hedi , Hooshyaripor Farhad , Danandeh Mehr Ali , Vosoughifar Hamidreza , Hosseini Seyed Abbas , Maghrebi Mohsen , Noori Roohollah
Published: November 2023

This study proposes a numerical model for depth-averaged Reynolds equations (shallow-water equations) to investigate a dam-break problem, based upon a two-dimensional (2D) second-order upwind cell-centre finite volume method. The transportation terms were modelled using a modified approximate HLLC Riemann solver with the first-order accuracy. The proposed 2D model was assessed and validated through experimental data and analytical solutions for several dam-break cases on a wet and dry bed. The results showed that the error values of the model are lower than those of existing numerical methods at different points. Our findings also revealed that the dimensionless error parameters decrease as the wave propagates downstream. In general, the new model can model the dam-break problem and captures the shock wave superbly.
Numerical Study on the Influence of Combined Rectification Facilities on the Flow in the Forebay of Pumping Station
Authors: Zheng Xiaobo , Zhang Pengli , Zhang Wenjing , Yu Yue , Zhao Yaping
Published: November 2023

The flow pattern of the forebay of the pumping station has a considerable effect on the operating efficiency and stability of the pump unit. A good forebay flow pattern can enable the pump unit to improve efficiency and operating conditions. This study takes a large pumping station as the research object and considers two rectification schemes, namely, a single bottom sill and a “bottom sill + diversion pier”. Without rectification facilities under different start-up schemes, the forebay flow pattern after the addition of rectification facilities is calculated, and the influence of single and combined rectification facilities is analyzed. Results show large-scale undesirable flow structures such as backflow and vortex in the forebay of the original design that without rectification facilities and uneven flow distribution occurs in the operating unit. The addition of a bottom sill in the forebay can control the central water beam from the water diversion pipe. The flow is divided to spread to both sides of the forebay and can be rectified twice after installing the diversion piers. The combined rectifier facility of “bottom sill + diversion pier” is beneficial to disperse incoming flow and make the flow distribution of each unit more uniform. The backflow and vortex inside the forepond are basically eliminated, and the flow state of the forepond is significantly improved.
Century-old experience of land management and formation of new agricultural landscapes in the Central Chernozem Region
Authors:   Land Management and Cadastre Faculty, Land Cadastre Department , Voronezh State Agrarian University named after Peter the Great, Voronezh, Kharitonov A.A. , Nedikova E.V. ,   Land Management and Landscape Design Department, Voronezh State Agrarian University named after Peter the Great, Voronezh
Published: November 2023

To the 100th anniversary of the Land Management and Landscape Design Department of the Voronezh State Agrarian University/ The anniversary article is devoted to the history of the formation and development of the Department of Land Management and Landscape Design of the Faculty of Land Management and Cadastre of the Voronezh State Agrarian University. The analysis of 100-years experience in land management and the formation of new agricultural landscapes in the Central Black Earth region is presented in this paper. The authors also propose the measures to improve land management at the present stage.
Prerequisites and Criteria for the Development of a Foreign Trade Classifi er of the Eff ectiveness of Government Support Measures for the Export Activities
Authors:   Russian Presidential Academy of National Economy and Public Administration (RANEPA), Institute of Applied Economic Research, Moscow, Shapor M. A. , Gevorgyan R. R. ,   Russian Presidential Academy of National Economy and Public Administration (RANEPA), Moscow
Published: November 2023

The presented work opens a series of articles devoted to the development of a classifier of measures of state support for exports, distributed by industry. The fi rst part of this section of this work includes a review of approaches, methods and results of assessing the export potential of states and mechanisms of state support for the country’s exports. To this end, this work reviewed studies that presented approaches to increasing the export potential of states, as well as the mechanism for their application. In addition, this section of this work examines the structure of exports of a number of countries, which also forms the necessary prerequisites for the formation of approaches to assessing the export potential presented in the sectoral context. The second part of the work is devoted to mechanisms of state support for exports. The third part of this work presents an overview of foreign experience. This article examined the theoretical aspects of the study of mechanisms of state support for the country’s exports, which made it possible to formulate the following prerequisites for the formation of a classifi er of measures of state support for the country’s exports: 1. The presented classifi er must be highly specialized, which will allow, based on the patterns formulated in the context of individual product groups, to describe promising areas of export and import supplies, taking into account the mechanisms of state support for exports proposed for each group of countries. 2. The proposed classifier must have not only qualitative, but also quantitative certainty, which will allow assessing the effectiveness of government support mechanisms for exports in the context of the product groups under study. 3. As indicators used within the proposed model of state support for exports, it is planned to use groups of indicators presented in the study by P. Cavers in the form of filters.