bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH UMUR PANEN TERHADAP PRODUKSI DAN AKTIVITAS ANTIOKSIDAN ANGGUR LAUT (Caulerpa racemosa) DENGAN METODE TANAM RIGID QUADRANT NETS
Authors: Firda Hasdinar , Junaidi Muhammad , Setyono Bagus Dwi Hari
Published: July 2022

Anggur laut Caulerpa racemosa merupakan salah satu jenis rumput laut yang memiliki prospek cerah untuk diproduksi dan dikembangkan, karena memiliki keunggulan dapat menghasilkan metabolit sekunder, memiliki keunggulan di bidang farmasi seperti aktivitas antioksidan, anti koagulan, anti mutagenik, anti bakteri, anti kanker, dan aktivitas anti tumor. Namun, mutu produksi dan kandungan bahan aktif pada tanaman salah satunya dipengaruhi oleh umur panen, agar tidak terjadi penurunan mutu dan kandungan bahan aktif tetap terjaga, diperlukan upaya untuk dapat menghambat kerusakannya. Tujuan dari penelitian ini untuk mengetahui pada umur panen berapakah anggur laut dapat menghasilkan mutu produksi yang tinggi dan aktivitas antioksidan. Metode yang digunakan pada penelitian ini adalah metode eksperimental dengan Rancangan Acak Lengkap (RAL). Terdapat 5 perlakuan, P1 anggur laut dipanen pada umur 20 hari, P2 anggur laut dipanen pada umur 25 hari, P3 anggur laut dipanen pada umur 30 hari, P4 anggur laut dipanen pada umur 35 hari dan P5 anggur laut dipanen pada umur 40 hari dilakukan 3 kali ulangan. Hasil penelitian menunjukkan bahwa umur panen anggur laut Caulerpa racemossa yang berbeda dan dibudidayakan menggunakan media tanam rigid quadrant nets berpengaruh  nyata terhadap pertumbuhan mutlak, namun tidak berpengaruh nyata terhadap laju  pertumbuhan  spesifik dan  tidak berpengaruh  nyata  terhadap kadar antioksidan, untuk memperoleh  kadar antioksidan, pertumbuhan bobot mutlak dan laju pertumbuhan spesifik yang optimal dalam budidaya anggur laut Caulerpa racemossa, digunakan umur panen 30-40 hari.
OS DESAFIOS DA OBRIGAÇÃO ALIMENTAR EM TEMPOS DE CRISE: REFLEXÕES DE UM (QUASE) PÓS-PANDEMIA
Authors: Ferreira Jardel Ribeiro , FRANCO KARINA BARBOSA
Published: July 2022

Introdução

As relações sociais e jurídicas foram profundamente transformadas em razão da pandemia imposta pela disseminação do SARS-CoV-2 (COVID-19). Embora não há muito tempo tenhamos vivenciado o i
A hybrid deep learning model to forecast air quality data based on COVID-19 outbreak in Mashhad, Iran
Authors: Maryam Zare Shahne , Amir Sezavar , Fatemeh Najibi
Published: July 2022

The SARS-CoV-2 (COVID-19) pandemic outbreak has led to some lockdowns and changed human mobility and lifestyle in this country. Mashhad, one of the most polluted cities in Iran has experienced critical air pollution conditions in recent years. In the present study, the potential relationships between air quality conditions (such as popular index and criteria air pollutant concentration) and COVID-19 cases and deaths were investigated in Mashhad, Iran. To do that, the Long Short-Term Memory (LSTM) based hybrid deep learning architecture was implemented on AQI, meteorological data (such as temperature, sea level pressure, dew points, and wind speed), traffic index and impact number of death, and active cases COVID-19 from March 2019 to March 2022 in Mashhad. The results reveal the LSTM model could predict the AQI accurately. The lower error between the real and predicted AQI, including MSE, MSLE, and MAE is 0.0153, 0.0058, and 0.1043, respectively. Also, the cosine similarity between predicted AQI and real amounts of it is 1. Moreover, in the first peak of the pandemic (Aug 2021), we have the minimum amount of AQI. Meanwhile, by increasing the number of active cases and death and by starting lockdown, because the traffic is decreased, the air quality is good and the amount of AQI related to PM2.5 is 54.68. Furthermore, the decrease the active cases and death in pandemic causes a significant increase in AQI, which is 123.52 in Nov 2021, due to a decline in lockdowns, resumption of human activities, and probable temperature inversions.
Successful use of IFN-γ for refractory systemic infection with Candida tropicalis in a child with AML and CARD9 mutation
Authors: Katharina Kleinschmidt , Anja Troeger , Juergen Foell , Marcus Jakob , Selim Corbacioglu
Published: July 2022

Infectious complications remain major causes of treatment-related morbidity and mortality in children with acute myelogenous leukemia (AML) due to the intensive chemotherapeutic regimens needed to treat this disease. Invasive fungal infections (IFI) represent a particularly severe condition that affects 5% - 13% of AML patients with a persistently unacceptable mortality rate of 40%.
A Missão Profética da Igreja nos Tempos Atuais
Authors: Comblin José
Published: July 2022

Na atualidade estamos assistindo a um renascimento do tema do profetismo na consciência que a Igreja toma de si mesma. Na eclesiologia dos séculos anteriores pouco se falava dos profetas, para não dizer que a questão do profetismo nem se colocava. Falava-se dos profetas do Antigo Testamento na apologética. Pois o argumento das profecias vinha reforçar o argumento dos milagres. Milagres e profecias eram provas da credibilidade de Jesus Cristo. Os profetas interessavam naqueles trechos que enunciavam de antemão o que se realizou na vida e na morte de Jesus. O fato de a vida de Jesus ter sido anunciada desse modo vários séculos antes dos acontecimentos aparecia como milagre. Portanto, Jesus merecia confiança: Só Deus podia conhecer a vida de Jesus e anunciá-la antecipadamente. Os profetas eram homens do passado que tinham sido instrumento de Deus para manifestar esse milagre. O resto não parecia fornecer assunto para reflexão teológica...
Teologia e Ciências no Diálogo Interdisciplinar
Authors: Taborda Francisco
Published: July 2022

Refletir sobre a relação interdisciplinar tornou-se nos últimos anos cada vez mais frequente. Dentro do programa de «diálogo com o mundo moderno» instaurado pelo Concílio Vaticano II não é de estranhar que o tema tenha também granjeado a atenção da Teologia, o que, aliás, é muito natural, se se tem cm vista a larga experiência interdisciplinar que a Teologia cristã traz desde suas origens...
O que Significa Propriamente o Sacramento?
Authors: Boff Leonardo
Published: July 2022

Atualmente, mais do que em outros tempos, os sacramentos são questionados. Para recuperar o sentido originário do sacramento precisamos descer a um nível mais profundo da reflexão e da realidade. Aí aparece o sacramento como a corporificação de um modo de pensar, pelo qual se tenta exprimir, numa unidade tensa, realidades que tomadas em si parecem se contraporem: o divino e o humano, o visível e o invisível, o temporal e o eterno. O sacramento traduz a comunhão destas realidades polares; faz uma presente na outra; encarna o divino e transfigura o humano. Neste nível, o sacramento não emerge tanto como gestos e coisas sagradas da religião, mas como o modo pelo qual Deus se comunica e se faz presente no mundo. O sacramento é a mediação pela qual e na qual Deus, Jesus Cristo, sua graça, a Igreja etc. atingem os homens...
Deputy editor-in-chief’s preface to Issue 3, 2022
Authors: Rychkova L. V.
Published: July 2022

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Predicting the severity of viral bronchiolitis in children
Authors: Bochkareva L. S. , Miromanova N. A. , Miromanov A. M.
Published: July 2022

Acute viral bronchiolitis is one of the common causes of hospitalization and mortality, especially among children in the first year of life who have risk factors (prematurity, congenital heart defects, bronchopulmonary dysplasia, immunosuppression). As factors associated with the severe course of bronchiolitis, along with the traditional ones, single nucleotide polymorphisms of the genes of the immune response molecules can be considered.The aim. Based on the analysis of clinical, laboratory and molecular genetic parameters, to identify prognostic criteria for the severe course of acute viral bronchiolitis in children.Materials and methods. The study included 106 children with acute viral bronchiolitis (severe course – 34, mild course – 72), the etiology of which in 67.9 % was respiratory syncytial virus. Forty-seven anamnestic, clinical, traditional laboratory and molecular genetic parameters were assessed as prognostic criteria. Determination of SNP genes of cytokines IL-4 (C-589T), IL-10 (G-1082A), IL-10 (C-592A), IL-10 (C-819T), TNF-α (G-308A), IL-17A (G197A), IL-17F (His161Arg), TLR2-753ArgGln, TLR6-Ser249Pro in venous blood was carried out by the polymerase chain reaction method.Results. An additional criterion for the risk of developing a severe course of bronchiolitis can be the mutant genotype (AA) SNP of the IL-10 gene (C-592A), which was detected exclusively in the group of patients with severe bronchiolitis, increasing the risk of developing a severe disease by 16.11 times (OR = 16.11; 95 % CI: 0.81–121.22, p = 0.02) in conjunction with already established modifying factors: the presence of congenital heart disease, bronchopulmonary dysplasia, prematurity, birth weight < 1500 g. Based on a comprehensive assessment of the established risk factors, a method has been developed that allows calculate the likelihood of developing a severe course of acute viral bronchiolitis. Conclusion. The use of the developed prediction method will not only increase the likelihood of developing severe acute viral bronchiolitis in children, but also determine the priority group among children with predictors of severe viral bronchiolitis for priority immunoprophylaxis against RS-virus infection.
Antibiotic resistance of enterobacteria isolated from freshwater bodies of different climatic zones
Authors: Zatsarinnaya E. A. , Kolupaeva N. V. , Kolupaeva L. V.
Published: July 2022

An important problem of our time is the resistance of bacteria to antimicrobial drugs. Surface water bodies accumulate all kinds of antibiotic-resistant bacteria found in the catchment area.The aim. To compare the antibiotic resistance of enterobacteria isolated from freshwater ecosystems of the Murmansk and Ryazan regions.Methods. Isolation was performed by the disk-diffusion method. For species identification, the “Rapid-entero 200 M” test system was used. Sensitivity was determined to 19 antibacterial drugs by the disk diffusion method in accordance with the requirements of MUK 4.2.1980-04 and Clinical guidelines (2014). Data interpretation was carried out using EUCAST v. 7.0 (2017) criteria and the WHONET software package.Results. In 2016, 771 isolates of enterobacteria were isolated from the water bodies of the Ryazan region, 323 isolates from the Murmansk region. The results showed that enterobacteria were found in all surveyed surface water bodies. Citrobacter (36 %), Escherichia coli (21 %) and Providencia (21 %) dominated in the Ryazan region, while Citrobacter (35 %) and Enterobacter (21 %) dominated in the Murmansk region. Enterobacteria resistant to one or more antimicrobials dominate in both regions. The phenotype of multiple drug resistance (MDR) was found in 82.62 % of isolates in Ryazan and 95.98 % in Murmansk regions. The extreme resistance phenotype (XDR) was more common among enterobacteria isolated from water bodies of the Ryazan region. In both districts, there was a fairly high level of resistance to beta-lactam antibiotics. In both regions, the quinolones were the most effective group for inhibiting the growth of enterobacteria.Conclusion. The results of the study show that the spread of antibiotic-resistant isolates of enterobacteria in freshwater ecosystems occurs everywhere, but in northern waters this process is slower.
Role of alarmone (p)ppGpp in the regulation of indole formation depending on glucose content in  Escherichia coli
Authors: Kashevarova N. M. , Akhova A. V. , Khaova E. A. , Tkachenko A. G.
Published: July 2022

Signaling molecules such as indole (product of tryptophan catabolism) and (p)ppGpp (stringent response regulator) are involved in regulation of physiological processes in bacterial cells aimed to adapt to antibiotics and stresses. However, question of existence of relationship between the stringent response and indole signaling requires more detailed investigation.The aim. To study effect of stringent response regulator (p)ppGpp on indole production in Escherichia coli depending on glucose content.Materials and methods. In this work, we studied the dynamics of indole accumulation in batch cultures of parent E. coli BW25141 ((p)ppGpp+ strain) and deletion mutant BW25141∆relA∆spoT ((p)ppGpp0 strain) in glucose-mineral tryptophan-free M9 medium, as well as with 2 mM tryptophan addition. In order to study effect of starvation stress on bacterial cell ability to synthesize indole, we used a model of growth limitation by carbon substrate at two glucose concentrations, 0.1 % and 0.4 %.Results. We have shown here that (p)ppGpp absence in E. coli cells reduces their ability to produce indole in the tryptophan-free medium and significantly slows down the rate of its accumulation in the tryptophan-containing one. Low glucose concentration (0.1 %) leads to decrease in indole production by (p)ppGpp+ cells in the tryptophan-free medium. The presence of indole synthesis precursor, tryptophan, in growth medium, on the contrary, increases the production of indole at lower glucose concentration in both (p)ppGpp+ and (p)ppGpp0 strains demonstrating direct dependence of delay time for onset of indole formation on glucose content, which is more pronounced in the culture of deletion mutant unable of synthesizing (p) ppGpp. The data obtained can be interpreted as result of complex regulatory effect of catabolic repression and the stringent response caused by alarmone (p)ppGpp action on expression level of tnaCAB operon responsible for indole biosynthesis.
Gene expression in farm poultry under the influence of T-2 toxin and the use of biological preparations
Authors: Yildirim E. A. , Grozina A. A. , Ilina L. A. , Filippova V. A. , Laptev G. Y. , Ponomareva E. S. , Dubrowin A. V. , Kalitkina K. A. , Molotkov V. V. , Akhmatchin D. A. , Tiurina D. G.
Published: July 2022

Background. Feed-borne T-2 toxin may inhibit innate immune system function in birds.The aim. To evaluate the effect of T-2 toxin, artificially introduced with feed, on the expression level of a number of immunity-related genes in the tissues of the broiler digestive system.Materials and methods. The experiments were carried out in the vivarium of the FSC “VNITIP” RAS broilers of the Smena 8 cross from 33 to 47-day old. Experimental contamination of feed T-2 toxin was performed. The birds were divided into 4 groups of 5 animals each: I – control, receiving a diet without the introduction of T-2 toxin, II experimental – receiving a diet with the addition of T-2 toxin, III experimental – receiving a diet with the addition of T-2 toxin and the sorbent Zaslon2+, IV experimental – receiving a diet with the addition of T-2 toxin, the same sorbent Zaslon2+and Axtra Pro enzyme. The level of mRNA expression was analyzed by quantitative reverse transcription PCR.Results. The data obtained indicated the impact of T-2 toxin contamination of broiler feed on the modulation of the level of expression of genes associated with the functioning of the immune system in the cecum and pancreas. Exposure to T-2 toxin (group II) led to an increase in the expression of the pro-inflammatory gene IL-6 in the tissues of the caecum by 10.8 times and IL-8 in the pancreas by 3.89 times (p ≤ 0.05) compared with control group I. The effect of the sorbent, as well as the complex, including the sorbent and the enzyme, on the expression of broiler genes was positive. The sorbent without the enzyme showed greater efficiency than with the additional introduction of the enzyme.
Features of dynamics of identity in women with polycystic ovarian syndrome and their socio-demographic determinants
Authors: Kuzmin M. Yu. , Marianian A. Yu. , Suturina L. V.
Published: July 2022

With a significant prevalence of polycystic ovary syndrome (PCOS), the question of its impact on the identity of women, the specifics of such identity, as well as its dynamics remain debatable.The aim. To study the features of identity dynamics in women with PCOS and the socio-demographic factors that determine these features.Research methods. A retrospective cohort study was conducted using the SEI-test methods and the Russian language versions of the Life Line, Twenty Statements Test methods on a sample of 110 women of reproductive age (58 women with PCOS, 52 women without PCOS; two surveys during the year).Results. Had been shown that women diagnosed with PCOS show fewer signs of an identity crisis than women without such diagnosis, but their identity is more variable. Such women are less likely to characterize themselves with the help of concepts related to gender and family spheres in favor of personality traits. An analysis of the influence of socio-demographic factors showed that their identity determines a greater number of external factors than in women without PCOS. The ego-identity of such women depends on marital status and place of residence.Conclusion. The identity of women diagnosed with PCOS is more variable, but shows fewer signs of a crisis. It seems necessary to take into account the presence or absence of children when planning further research. The results obtained can be used in the consultation of women with PCOS.
The role of obstetric pessary and micronized progesteron in early preterm birth prevention in patients with multiple pregnancy
Authors: Belinina A. A. , Barinov S. V. , Kadtsyna T. V. , Kolyado O. V. , Molchanova I. V.
Published: July 2022

Background. Multiple pregnancy is a well-established risk factor for preterm birth. Prevention of early termination of pregnancy is a priority problem in obstetric practice.The aim. To evaluate the role of an obstetric pessary and micronized progesterone in the prevention of early preterm labor in patients with multiple pregnancies.Materials and methods. A prospective controlled study was conducted with the inclusion of 146 pregnant women with multiple pregnancies, which, depending on the methods of treatment, were divided into three groups: Group I (n = 67) – pregnant women who received micronized progesterone in combination with an obstetric pessary; Group II (n = 57) included women who received micronized progesterone; Group III (n = 22) consisted of patients with multiple pregnancies without therapy.Results. In Group I, the complex of an obstetric pessary and micronized progesterone allowed to reduce the frequency of preterm birth by 2.3 times (p = 0.008) in comparison with Group III, the frequency of births at gestational age ≤ 34 weeks – by 8.1 times (p = 0.005) in compared with Group III and 2.7 times (p < 0.01) compared with Group II. In 70.4 % of pregnant women, the use of a complex of an obstetric pessary with micronized progesterone made it possible to prevent the formation of isthmiccervical insufficiency, which, according to sonography, was expressed in the dynamics of the utero-cervical angle towards a more obtuse one.Conclusion. The use of an obstetric pessary with micronized progesterone made it possible to reduce the risks of isthmic-cervical insufficiency by 7.7 % compared with patients who received only micronized progesterone therapy, and by 17.1 % compared with pregnant women who did not receive therapy.
Comparison of the composition and metabolic potential of the reindeer’s rumen microbiome in the Yamal-Nenets and Nenets autonomous district of the Russian Arctic
Authors: Ponomareva E. S. , Yildirim E. A. , Filippova V. A. , Ilina L. A. , Dubrowin A. V. , Laptev G. Y. , Kalitkina K. A. , Dunyashev T. P. , Tiurina D. G.
Published: July 2022

The adaptive ability of reindeer to the harsh conditions of the Russian Arctic is not determined solely by the genome of the macroorganism and, of course, includes an extensive genetic and metabolic repertoire of the microbiome.The aim. To compare the taxonomic and predicted metabolic profiles of the rumen microbiome of adult reindeer living in the natural pastures of the Yamalo-Nenets and Nenets Autonomous districts of the Russian Federation.Materials and methods. Expeditions to the Yamal-Nenets and Nenets Autonomous districts of the Russian Arctic in 2017 were carried out to take samples of the rumen. The contents of the rumen were taken from clinically healthy reindeer individuals (at least 3 times repetition). To analyze the animal scar microbiota and determine metabolic profiles, 16S rRNA NGS sequencing was performed on a MiSeq device (Illumina, USA). Bioinformatic data analysis was performed using QIIME2 software ver. 2020.8. The noise sequences were filtered by DADA2. Silva 138 reference database was used for taxonomy analysis. Reconstruction and prediction of the functional content of the metagenome was carried out using the software complex PICRUSt2 (v. 2.3.0).Results. During NGS sequencing, a total of 223 768 sequences of the 16S rRNA gene of the reindeer scarring microbiome were studied. Significant (p ≤ 0.05) differences between the groups in 10 bacterial phyla and superphyla were revealed: Actinobacteriota, Spirochaetes, Chloroflexi, Verrucomicrobia, Bdellovibrionota, Synergistetes, Fusobacteriota, Myxococcota, Cyanobacteria, Campilobacterota. The results of the reconstruction and prediction of the functional content of the metagenome using the PICRUSt2 bioinformatic analysis made it possible to identify 328 potential metabolic pathways. Differences between the groups were revealed in 16 predicted metabolic pathways, among which the pathways of chlorophyllide and amino acid biosynthesis dominated.
The effect of Anavidin on  Rhodococcus qingshengii VKM Ac-2784D depending on the carbon source in the cultivation medium
Authors: Markova Yu. A. , Belovezhets L. A. , Morits A. S.
Published: July 2022

Background. Microorganisms have significant plasticity, therefore, the effectiveness of the use of disinfectants is due to the conditions of their use. This is because microorganisms, depending on their habitat, may have different resistance to the same active substance.The aim. To study the effect of Anavidin-Complit on the growth and biofilm formation of Rhodococcus qingshengii VKM Ac-2784D, depending on the carbon source in the cultivation medium.Materials and methods. R. qingshengii VK MAc-2784D was used in the work, the studies were carried out on a mineral nutrient medium 8E, into which 0.5 % glucose, inositol or naphthalene was added as a carbon source. Anavidin was used at a final concentration of 0.08, 0.04, 0.02, 0.01 and 0.005 %. Growth and biofilm formation were evaluated by standard microbiological methods.Results. The disinfecting effect of Anavidin-Complit on the growth of the planktonic form of R. qingshengii VKM Ac-2784D depends on the carbon source. If in a starvation cultivation medium, all concentrations of Anavidin-Complit had an adverse effect on bacteria throughout the experiment, then in the presence of glucose, the adverse effect of low concentrations of Anavidin-Complit decreased by the end of the experiment. In the medium with naphthalene, on the contrary, on the first or second day of cultivation, low concentrations of Anavidin-Complit had a stimulating effect. Anavidin-Complit, depending on the concentration, suppressed the formation of a biofilm on all cultivation media. Microscopy of the biofilm in some cases revealed dense rounded formations consisting of several layers of cells.Conclusion. Thus, in order to increase the effectiveness of disinfectants, a deeper study of the physiological response of microorganisms is necessary, taking into account their living conditions.
The Feel of the Guitar in Popular Music Performance
Authors: Shea Nicholas
Published: July 2022

Popular-music guitarists frequently reference the physicality of the fretboard when discussing songwriting and performance. Brittany Howard, for example, advocates that the feel of her guitar and physical gestures — chord shapes, licks, and riffs — are more critical to her craft than theoretical knowledge regarding pitch and harmony. However, in-depth gestural perspectives on musical organization are underrepresented in popular-music scholarship. This video article responds by investigating the relationship between fretboard gestures and popular music’s features in two contexts. First is a close analysis of “Short and Sweet” that focuses on how Howard coordinates chord voicings and larger left-hand shifts with important rhetorical moments reflected in the song’s lyrics. A following motion-capture study then surveys how similar gestural trends might generalize to performances by other guitarists. Data from performances by 14 local practicing guitarists demonstrate that the musicians typically prefer to articulate moments of formal transition with the largest physical gestures. Such findings suggest a degree of gestural intentionality and strategy amongst guitarists and clarify the contexts in which a guitarist might choose to maintain or abandon fretboard affordances.
Acting and Behaving: The Philosopher in Ancient Greece and Late Modernity
Authors: La Matina Marcello
Published: July 2022

Around the world scientific output has reached ungovernable levels; far more is written than can possibly be read. Also, there are increasingly clear signs of rampant conformity within the scientific community. Where does philosophy stand in all this? Can we continue to claim that the role of knowledgeable persons and the discourse with which they impart their knowledge are (free, individual) ways of acting? Or should both role and discourse be considered mere modes of (conformist, impersonal) behavior? By comparing modern practices to models of ancient Greek philosophy, philosophy of language enables us to reflect (especially historically) on the meaning of a life in theory, the role of logos, and the praxis within current discursive and philosophical practices. Our thesis is that the doing of the ancient philosopher (his form of life) works as a discourse, and that this discourse is also a discourse on the limits of language.
λεκτόν and Use
Wittgenstein and the Incorporeal
Authors: Cimatti Felice
Published: July 2022

Any theory of language – ancient or contemporary, philosophical or cognitive – faces the same problem, i.e. how to reconcile the unequivocally corporeal character of the speakers and the world they speak of with the somewhat ‘incorporeal’ character of the meanings of linguistic expressions. It is for this reason, for example, that direct-reference theories of language (Stroll 1999) seek to eliminate the Fregean notion of 'sense' (Sinn) from semantics. What is at stake is a completely corporeal account of language. However, such an attempt clashes with the fact that the vast majority of linguistic expressions do not refer either to any objects in the world or to the pre-scientific intuition that words have an autonomous 'meaning' (that is, that the 'sense' of a word does not coincide with the referent, Bedeutung).
To solve such a problem, the Stoics introduced in their theory of language the notion of lekton, i.e. what is 'said' or is 'sayable'. Even if the lekton is, properly speaking, incorporeal, at the same time it is the corporeal product of what human speakers do when they utter a verbal utterance. In this paper I propose to compare the notion of lekton to the similar notion of 'use' (Gebrauch), much debated in Ludwig Wittgenstein’s Philosophical Investigations. The thesis of this paper is not that there exists a direct philological connection between the Stoic notion of lekton and the notion of linguistic 'use' in Wittgenstein (even if this cannot be excluded either). Instead, the idea is that when one wants to propose an adequate theory of language, one cannot but introduce a notion such as that of lekton or 'use'.
Evidence of geosystems transformation during Medieval development of South Primorye: Steklyanukha-2 fortress
Authors:   Pacific Institute of Geography of the Far Eastern Branch of RAS, Kornyushenko T.V. , Razjigaeva N.G. ,   Pacific Institute of Geography of the Far Eastern Branch of RAS, Ganzey L.A. ,   Pacific Institute of Geography of the Far Eastern Branch of RAS, Grebennikova T.A. ,   Pacific Institute of Geography of the Far Eastern Branch of RAS, Kudryavtseva E.P. ,   Pacific Institute of Geography of the Far Eastern Branch of RAS, Piskareva Ya.E. ,   Institute of History, Archaeology and Ethnology of the Peoples of the Far East of the Far Eastern Branch of RAS, Prokopets S.D. ,   Institute of History, Archaeology and Ethnology of the Peoples of the Far East of the Far Eastern Branch of RAS
Published: July 2022

We analyzed human impact on landscapes on the example of Steklyanukha-2 Medieval fortress, which is a multi-layered archaeological site, and adjacent territories. Buried soils, rampart matrix, cultural layer and surface soils were sampled within the fortress. Along with the material sampled at the site, two sections of the Upper Holocene deposits of the high floodplain of the Steklyanukha River were studied. The results of studying the sporo-pollen spectra and diatoms are presented. The paleo-landscapes during the formation of various archaeological cultures have been restored and the signs of anthropogenic impact on vegetation have been identified. The buried soil in the section of the high floodplain is a natural archive for the environment history during the appearance of the people of the Yankovskaya Culture on this territory. The soil was formed under conditions of decreasing watering in the valley; the age is estimated at more than 2 ka. Oxbow lake deposits had been accumulated from 1.6 to 0.5 ka, when the valley was actively developed in the Middle Ages. Floodplain deposits at the top of the sections indicate that the valley has been heavily watered during the Little Ice Age. Pollen signs of settlements of the lower part of the valley in the Early Iron Age, Mohe and Late Middle Ages were found. Signals of the development of secondary birch and oak forests are identified. Ambrosia and Xanthium pollen, which are reliable evidence of agricultural activity in the valley, was found in the cultural layer and sediments that formed in the Middle Ages. The pollen of plants common in anthropogenically disturbed territories was also found. The study of diatoms in a depression within the fortress confirmed the archaeologists’ assumption that it was used to store water reserves. The pollen spectra from the surface soils in the fortress and the high floodplain reflect the active agricultural development of the nearby river valleys since the second half of the 19th century. The largest amount of pollen of alien and synanthropic plants and weeds, as well as spores of pathogenic fungi (pathogens of soybeans and rice) and fire indicators were found here.
Scrum in Project Risk Management in Cultural Institutions
Authors: Krawczyńska Alicja
Published: July 2022

Cultural animation and education is one of the goals of cultural institutions. In practical terms, this goal
is often implemented through projects, which are also a way to obtain additional financial resources.
Hence, projects are part of the work of cultural institutions. Agility understood as flexibility in management,
is, therefore, becoming a necessity in cultural institutions, and project risk management as an
important part of the management process. This resulted to the proposal to apply the Scrum approach
to risk management in projects implemented by cultural institutions. Empiricism, adaptation, and iteration
are inherent in Scrum. In this respect, they correspond to both the mission of cultural institutions
and the need to adapt activities to the changeability of the environment. Pilot research carried out in
three cultural projects indicates that the proposed model of risk management using the Scrum approach
allows to manage project risk thanks to systemised work of the project team, transparency of activities,
and adaptation of the project to the variability of the environment in subsequent iterations resulting
from the Scrum approach. This article presents the results of the research and their implications for
project management in cultural institutions.
Green Marketing – a New Norm: a Qualitative Evidence of Green Marketing
Challenges and Future Perspectives
in High-Low Context Communication
Cultures
Authors: Skackauskiene Ilona , Vilkaite-Vaitone Neringa
Published: July 2022

This study aimed to explore current challenges and future perspectives of green marketing. The researchers
interviewed nine marketing managers from arts, energy, hospitality, telecommunications,
digital printing, cosmetics, and windows XXABSTRACT doors enterprises in Lithuania, which belongs to high-context
communication culture, and Norway, which is a low-context culture. The interviewed marketing professionals
who represented organizations with an environmentally conscientious cultural value identified
many green marketing challenges, such as greenwashing, great resource demand, COVID-19, lack of
society and employee awareness, insufficient or malfunctioning government support, shortage of ideas,
and lack of supply. The findings indicated that the challenges of green marketing vary across industries
and enterprises that differ in the number of employees. The study also found that increasing society’s
awareness, promoting inspiring cases, recycling incentives, digitalization, and packaging innovations
could be valuable inspirations to overcome these challenges. The research findings will be helpful for
academics and marketing managers interested in understanding, implementing, and developing green
marketing solutions for achieving business sustainability in high- and low-context communication cultures.
Remote Work and Other Effects of the COVID-19 Pandemic in Enterprises and Cultural Management
Authors: Horváthová Petra , Mokrá Kateřina , Štverková Hana
Published: July 2022

Due to the COVID-19 pandemic, companies, not only in the cultural management, and their employees
had to cope with a number of changes, and people faced new challenges, not only in the workplace.
However, remote work has become a pandemic phenomenon. The aim of the article was to analyse the
experience with remote work during the COVID-19 pandemic in 2020 and 2021 in Enterprises on the
examples of Czech Republic and in worldwide cultural management, i.e. to prepare the state-of-the-art
report and, based on the report, to present recommendations for remote work in the future. The methodology
process was that at first, the secondary data were obtained by selection and content analysis
of 475 quantitative and qualitative print and virtual information published on the topic of pandemic
impact. Then through search, comparison and synthesis, an insight into the major changes that have
occurred in working life due to the pandemic has been gained. Based on induction, deduction and the
authors' own experience, recommendations were then made for the future use of remote work.
Amongst the findings of the article is a comprehensive view of the experience with the remote work
phenomenon, its positives and negatives, as well as a description of particular effects of coronavirus
pandemics on both employers and employees. The discussion then covers the recommendations on
how to better face and cope with these situations in the future, not only in our conditions but also in
conditions of similar economies.
Classification of VOC Vapors Using Machine Learning Algorithms
Authors: AKSOY Serra , ÖZAVSAR Muttalip , ALTINDAL Ahmet
Published: July 2022

Detection of volatile organic compound (VOC) vapors, which are known to have carcinogenic effects, is extremely important and necessary in many areas. In this work, the sensing properties of a cobalt phthalocyanine (CoPc) thin film at six different VOC vapors (methanol, ethanol, butanol, isopropyl alcohol, acetone, and ammonia) concentrations from 50 to 450 ppm are investigated. In this sense, it is observed that the interaction between the VOC vapors and the CoPc surface is not selective. It is shown that using machine learning algorithms the present sensor, which is poorly selective, can be transformed into a more efficient one with better detection ability. As a feature, 10 seconds of responses taken from the steady state region are used without any additional processing technique. Among classification algorithms, k-nearest neighbor (KNN) reaches the highest accuracy of 96.7%. This feature is also compared with the classical steady state response feature. Classification results indicate that the feature based on 10 seconds of responses taken from the steady state region is much better than that based on the classical steady state response feature.
Kinematics of Hooke’s Joint
Authors: Podrigalo Mikhail , Peregon Volodymyr , Boboshko Oleksandr , Bogdan Dmitrij , Koriak Oleksandr
Published: July 2022

Problem. An analysis of the literature has shown that some issues of the kinematics and dynamics of the Hooke’s joint are not fully covered. In particular, this applies to the determination of the kinematic characteristics of the relative movements of the links in the movable joints of the crosspieces and cardan yokes, as well as the acceleration of the crosspiece in the study of the hinge. These kinematic characteristics are the basis for dynamic analysis of the cardan transmission; they are used at research of operation of the bearings of a cardan joint cross; they are necessary to determine the energy expended to overcome the forces of friction in these kinematic pairs; they form the basis for evaluating transmission efficiency. Goal. The goal of this work is to determine the kinematic characteristics of the cross in its absolute and relative motions. Methodology. The research is based on the graphical and analytical method of kinematic analysis of spherical motion of a rigid body. At the initial stage, the calculated dependences for determining the angular velocity of the cross in its absolute and relative motions were obtained. The relative angles of rotation of the links in the movable joints of the crosspiece and cardan yokes were determined by integrating the corresponding differential equations. To determine the angular acceleration of the crosspiece, the theorem on the addition of angular accelerations of a rigid body rotating around two non-parallel axes was used. Results. The study of the kinematics of the cardan joint made it possible to identify and eliminate ambiguities in determining the relative angular velocities of the elements of the kinematic pairs of the cross and cardan yokes. Functional dependences for determination of angular acceleration of a crosspiece in absolute and relative movements, and also relative angles of rotation of links in kinematic pairs of a crosspiece and cardan yokes were received. It was shown that the angular acceleration of the crosspiece is a periodic function of the angle of rotation of the input link. During the operation of the hinge, the crosspiece creates insignificant periodic dynamic loads, which should be taken into account in accurate calculations of high-speed cardan transmissions. Practical value. The work is devoted to the study of the kinematics of the asynchronous hinge, which is the foundation for its dynamic analysis and ultimately aimed at improving the output performance of the cardan transmission. The research method combines mathematical calculations with simplicity and clarity of graphic constructions, which contributes to a deeper understanding of the kinematic features of a hinge of uneven angular velocities. The obtained results can be used in the design and study of motor-transmission units, which include the Hooke’s joint.
A New Admission System in Chile and Its Foreseen Moderate Impact on Access for Low-Income Students
Authors: Honey Ngaire , Carrasco Alejandro
Published: July 2022

Chile is known for universal school choice policies and a high level of economic segregation. In part, segregation has been linked to selective school admission policies. Chile implemented a centralized school admission system (New School Admission System), where PK–12 schools must accept any applicant, and lottery assignment is used for oversubscription. We exploit a natural experiment due to the phased implementation across grades and regions to attempt to detect any effects of this policy on access for and representation of low-income students using grade-within-school and year fixed effects. Eliminating admissions barriers may contribute to increased educational opportunity, but the impact may be limited by the multiple structural factors shaping inequality in Chile. We find little short-term change in access for low-income students.
Jell-O: Analisis Model Bisnis Kuliner dengan Pendekatan BMC & VPC
Authors: Zahra Tabina Litarachma
Published: July 2022

Bisnis makanan Jell-O seperti Instant pudding, Jello shot dan Jeli ada di mana-mana mengalami kenaikan (rise). Namun sejak tahun 2022, industri makanan ini mengalami penurunan (fall). Studi ini bertujuan untuk mengetahui alasan penurunan (fall) dan kenaikan (rise) pada bisnis makanan. Studi ini menggunakan studi kasus tunggal pada bisnis Jell-o yang bergerak di bidang makanan dengan analisis business model canvas, business pattern, business environment & value proposition canvas Bisnis makanan pernah tren pertumbuhan dan sukses karena memiliki value proposition produk yang mudah untuk dibuat, mudah untuk disajikan, dan terjangkau. Namun, bisnis makanan mengalami penurunan karena key activities tidak melakukan innovasi produk baru dan hanya melakukan innovasi pada variasi rasa saja. Studi merekomendasikan key activities membust produk Gelatin lembut seperti agar-agar tetapi lebih lembut dengan rasa yang manis dan terdapat berbagai variasi Jell-O dan juga melakukan marketing dengan cara membuat iklan yang strategis dan sukses sehingga bisa menarik para customer.
RÁC THẢI NHỰA Ở VIỆT NAM VÀ GIẢI PHÁP KHẮC PHỤC
Authors: TKLV QLKT
Published: July 2022

Rác thải nhựa Việt Nam và giải pháp khắc phục
Phase flow and surface solution
Authors: Vit Bytynaev
Published: July 2022

Phase flow and surface solution
Analisa pendekatan kebijakan pemerintahan daerah
Authors: Sunarti
Published: July 2022

Tulisan ini bertujuan untuk mengetahui gambaran penataan kelembagaan pada pemerintah daerah. Hasil tulisan ini menunjukkan bahwa penataan kelembagaan yang dilakukan oleh pemerintah daerah guna mewujudkan Good Governance masih relevan dengan pelaksanaan dan pembagian kewenangan dalam pola strukturisasi hal ini bisa dilihat dan dikaji dari hasil analisis dan pembahasan sebelumnya yang menurut sebahagian besar responden. Kemudian dalam hal penerapan dan pengadaan fasilitas teknologi mendapat perhatian responden bahwa masih layak dan mampu menjadi penunjang dalam operasional. Sementara dalam hal penempatan personil bisa dijadikan sebagai acuan bahwa personil sudah mampu bersinerji dengan tugas dan tanggungjawabnya, begitu pula dalam melakukan kerja sama sebagai satu kesatuan organisasi (team work). Faktor-faktor yang mempengaruhi pola restrukturisasi birokrasi yang dilakukan oleh pemerintah daerah guna mewujudkan Good Governance dapat dikaji dari berbagai segi, diantaranya masalah kepastian hukum. Menurut sebagian responden bahwa hal itu sudah dilakukan berdasarkan keadilan dan pemberlakuan hak dan kewajiban yang sama. Dalam ranah transparansi dan akuntabilitas pemerintah daerah telah berhasil menjadikan sebagai pola yang terbuka dan dapat diakses juga mengedepankan bentuk manajemen yang terbuka sebagai bentuk pertanggung jawaban moral. Dan juga mengenai hal-hal yang bersangkutan dengan pendekatan kebijakan pemerinta daerah adapun juga membahas mengenai pendekatan kebijakan pemerintah atau yang berhubungan dengan pemerinah daerah
Reducing the translational gap: Analytic Network Process to assess the link between collaborative practices and innovation in rare diseases
Authors: González-Urango Hannia , Poveda-Bautista Rocío , Díaz-Faes Adrian A. , Llopis Oscar , D'Este Pablo
Published: July 2022

Delivering quality healthcare relies on well-functioning research and innovation processes in biomedicine. New treatments, diagnostic methods and prevention protocols have expanded the capacity of health systems to meet urgent and chronic health needs. However, medical innovation does not flow automatically from basic and clinical research to medical practitioners and patients. Indeed, policy initiatives aimed to foster collaborative research networks in biomedicine, which bring together multiple stakeholders, have permeated the policy agendas of public funding agencies worldwide. Despite these policy efforts, there is little systematic analysis of how research and collaborations processes work in practice. Accordingly, the aim of this study is to develop an integrated multi-criteria analysis and qualitative approach to assess the extent to which different types of research collaboration activities contribute to medical innovation. This paper presents a methodological approach that allows to measure the impact of collaboration activities on healthcare performance in the context of a biomedical research networks in rare diseases. The results demonstrate how the stakeholder management carried by a research group leads to the achievement of outputs prioritized by the research group.
Howard Walter Florey – Wikipedia tiếng Việt
Authors: Nguyen Van-Quang
Published: July 2022

Howard Walter Florey, Nam tước Florey (24 tháng 9 năm 1898 - 21 tháng 2 năm 1968) là một nhà dược lý học và bệnh học người Úc. Ông đoạt Giải Nobel Sinh lý và Y khoa năm 1945 cùng Ernst Boris Chain và Alexander Fleming cho công trình chiết xuất penicillin. Các phát hiện của Florey được ước lượng đã cứu sống khoảng 80 triệu người trên thế giới. Florey được coi là một trong những nhà khoa học lỗi lạc nhất của Australia. ***** Chỉ dành cho mục đích lưu trữ thông tin *****
A guide for calculating study-level statistical power for meta-analyses
Authors: Quintana Daniel S
Published: July 2022

Meta-analysis is a popular approach in the psychological sciences for synthesizing data across studies. However, the credibility of meta-analysis outcomes depends on the evidential value of studies included in the body of evidence used for data synthesis. One important consideration for determining a study’s evidential value is the statistical power of the study’s design and statistical test combination for detecting hypothetical effect sizes of interest. Studies with a design/test combination that cannot reliably detect a wide range of effect sizes are more susceptible to questionable research practices and exaggerated effect sizes. Therefore, determining the statistical power for design/test combinations for studies included in meta-analyses can help researchers make decisions regarding confidence in the body of evidence. As the one true population effect size is unknown when hypothesis testing, an alternative approach is to determine statistical power for a range of hypothetical effect sizes. This tutorial introduces the metameta R package and web app, which facilitates the straightforward calculation and visualization of study-level statistical power in meta-analyses for a range of hypothetical effect sizes. Readers will be shown how to re-analyze data using information typically presented in meta-analysis forest plots or tables and how to integrate the metameta package when reporting novel meta-analyses. A step-by-step companion screencast video tutorial is also provided to assist readers using the R package.