bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of pulmonary vein anatomy on cryoballoon isolation results
Authors: Chichkova T. Yu. , Mamchur S. E. , Khomenko E. A. , Romanova M. P. , Kokov A. N.
Published: January 2020

Aim. To estimate the efficacy of pulmonary veins (PV) cryoballoon isolation in its different anatomical variants.

Methods. 230 patients 57 (53; 62) years of age were enrolled in the study in approximately equal proportion of males and females. Up to 1/3 of patients suffered from isolated AF, most of them belonged to the category of high risk of thromboembolic complications. To evaluate the PV anatomical variant, a modified classification of E. Marom et al was used. In groups of cryoballoon and radio-frequency isolation, subgroups of typical and variant anatomy were distinguished. Evaluation of the effectiveness of the intervention was based on the identification of any (symptomatic and asymptomatic) documented episodes of atrial arrhythmias lasting more than 30 seconds during the observation period of 12 months.

Results. Comparison of efficacy in typical PV anatomy did not reveal significant differences between cryo and RFA groups, regardless of the type of device used. Subgroup I of generation of cryoballoons showed freedom from AF 83.2%, II generation – 87.5%, RFA group – 82.7% at p = 0.82. At the same time, with PV variant anatomy, the efficiency of cryo isolation with the use of II generation devices was 52.2 versus 85.7% in the RFA group (OR = 0.25; 95% CI 0.09–0.71; p = 0, 02). When analyzing long-term results in cryo and RFA groups depending on the anatomical variant, it was found that with RFA, the presence of a left PV common trunk (collector / vestibule), as well as the presence of additional veins, showed results comparable with the group of typical anatomy. At the same time, in the cryoablation group, the presence of a left common trunk was accompanied by a decrease in efficiency to 23.1 versus 84.9% for typical anatomy (OR = 0.14; 95% CI 0.03–0.6; p = 0.02) and 90% in the presence of additional veins (OR = 0.1; 95% CI 0.01–0.64; p = 0.02). In the presence of a left common trunk, the efficiency of cryoablation using second-generation cylinders was 23.1 versus 82.4% in the RFA group (OR = 0.16; 95% CI 0.05–0.5).

Conclusion. The presence of a left PV common trunk leads to a decrease in the effectiveness of cryoablation in the long-term observation period relative to the group of typical anatomy to 23.1 versus 84.9% (OR = 0.14; 95% CI 0.03–0.6) and 82.4% for radiofrequency ablation (OR = 0.16; 95% CI 0.05–0.5). The presence of additional veins of right-sided localization does not affect the effectiveness of the intervention.
Educação Ambiental na Modalidade EAD: Um Estudo Bibliométrico
Authors: Oliveira Macsuel Miranda de , Rodrigues Denise Celeste Godoy de Andrade
Published: January 2020

O propósito do presente estudo foi descrever a produção científica sobre Educação Ambiental na modalidade a distância (EaD). Para tanto, foi realizada uma busca no Portal de Periódicos Capes com três argumentos de busca, com base nos quais foram encontrados doze artigos relacionados com Educação Ambiental na modalidade EaD. A pesquisa pode ser classificada, quanto ao seu objetivo, como descritiva. O procedimento técnico adotado foi a pesquisa bibliométrica, a partir da qual foi possível verificar que os estudos relacionados ao tema, em sua maioria, apresentam relatos de ações e práticas relacionados a Educação Ambiental em cursos de extensão. Também foram observados levantamentos, pesquisas documentais, bibliográficas, estudos de caso e observação participante. As instituições que mais se destacaram com pesquisas sobre o tema foram a Universidade Federal de Santa Maria, Universidade Federal do Ceará e Universidade Federal do Rio Grande.
Palavras-chave: Educação a distância. Educação ambiental. Bibliometria.
Effect of mechanical pressure on c-fos and on the mitotic activity of epidermal cells.
Authors: Tsanev R , Yaneva J , Vaptzarova K , Markov D
Published: January 2020

A dosed mechanical pressure of 12.5 kg/cm2 applied for 1 min on depilated mouse skin did not cause cellular death or visible alterations of the cellular ultrastructures. However, it had a strong effect on the mitotic cycle of the epidermal cells-stimulating the cells to enter the mitotic cycle and temporarily blocking the G1-->S transition. This effect was strictly limited to the pressed area of the skin. The proto-oncogene c-fos was induced within the first 2 min following application of the pressure. The level of c-fos mRNA showed two peaks during the next 24 h. The first slight peak was preceded by a rapid increase in the cAMP level in the pressed skin, the second-by a fall in the cAMP concentration. A model is suggested to explain the observed effects by reversible functional damage of the cellular membrane affecting the enzymes maintaining the steady state level of cAMP.
Interference between DNA binding activities of AP-1 and GR transcription factors in rat thymocytes undergoing dexamethasone-induced apoptosis.
Authors: Sikora E , Rossini G P , Grassilli E , Bellesia E , Salomoni P , Franceschi C
Published: January 2020

The early molecular events of glucocorticoid-induced apoptosis have been investigated by studying glucocorticoid receptor levels, as well as binding activities to GRE and AP-1 sequences, using nuclear extracts from dexamethasone (Dex)-treated rat thymocytes. When the time-course of glucocorticoid-receptor complexes in nuclei of thymocytes was evaluated by binding studies using the tritiated ligand, we found that nuclear accumulation of radioactive complexes occurred in the first hour of incubation, and was followed by a progressive decline. This trend was confirmed by immunoblotting of nuclear proteins using a monoclonal anti-glucocorticoid receptor antibody. When the kinetics of binding activity to AP-1 and GRE sequences were studied, using nuclear extracts prepared from Dex-treated thymocytes in gel shift assays, we found peaks at 1 and 2 h after Dex treatment, and a return to basal levels in the following hours. Binding specificity was proved by competition studies using non-radioactive sequences, including mutated AP-1. Unexpectedly, however, protein binding to GRE was better competed for by AP-1 sequence than by GRE itself. Data obtained using the super gel shift assay suggested that AP-1/Jun can be responsible for the high affinity for the GRE sequence. Thus, we report here for the first time that an interference between AP-1 and GR in the binding to DNA consensus sequences-previously described in other biological systems-also occurs during apoptosis induced by glucocorticoids in lymphoid cells.
Uridine phosphorylase from Hymenolepis diminuta (Cestoda): kinetics and inhibition by pyrimidine nucleoside analogs.
Authors: Drabikowska A K
Published: January 2020

A single pyrimidine nucleoside phosphorylase was found in the cytoplasmic extract from Hymenolepis diminuta. This enzyme preferentially cleaves uridine and, to a much lesser extent, thymidine. Its presence directly indicates the existence of pyrimidine nucleoside salvage pathway in this parasite. Detailed kinetic studies in the phosphorolytic and synthetic direction pointed to the sequential mechanism of these reactions. For phosphorolysis, Kurd = 33 microM and Kp = 806 microM. For synthesis of uridine, Kura = 204 microM and K1-P-rib. = 50 microM. Over six times higher K(m) for uracil than for uridine indicates that phosphorolysis is the favoured reaction in this tapeworm. Well known inhibitors of mammalian uridine phosphorylase: 2,2'-anhydro-5-ethyluridine and 1-(1,3-dihydroxy-2-propoxymethyl)-5-benzyluracil (DHPBU), both with Ki = 0.07 microM were potent competitive inhibitors of the enzyme from H. diminuta. The newly synthesized 2,3'-anhydro-5-ethyluridine (K. Felczak, unpublished) showed only moderate inhibitory activity (Ki = 14 microM) similarly as 1-(1,3-dihydroxy-2-propoxy-methyl)-5-benzyluracil. The same order of Ki values obtained for the investigated inhibitors vs uridine phosphorylase, irrespective whether the enzyme was isolated from rat intestinal mucosa (Drabikowska et al., 1987, Biochem. Pharmacol. 36, 4125-4128) or H. diminuta may point to a great similarity between binding sites on the parasite and the host enzyme.
Evidence for the presence of different alpha-1-proteinase inhibitor genes products in mouse plasma.
Authors: Dubin A , Mak P , Travis J
Published: January 2020

The plasma alpha-1-proteinase inhibitor (API) of three mouse species Mus domesticus, M. caroli and M. pahori was isolated. Each of the species isoforms were then separated by chromatofocusing; however, no significant differences in association rate constants toward human neutrophil elastase and bovine chymotrypsin were observed. The amino-acid sequence of the P'1-P'15 C-terminal fragments of the API variants indicate that mouse plasma contains at least two different active API isoforms in the case of M. domesticus (five API genes) but only one active API isoform in M. pahori and M. caroli (one API gene).
3' Noncoding sequences of the CTA 1 gene enhance expression of the recombinant serine protease inhibitor, CPTI II, in Saccharomyces cerevisiae.
Authors: Stankiewicz M , Rempoła B , Fikus M
Published: January 2020

Expression of the gene coding for the recombinant trypsin inhibitor, CPTI II, was enhanced tenfold when yeast transcription terminating sequences were added to the expression cassette of the pJK6 yeast vector. The yield was further increased about 20% in the BJ5464 yeast strain, defective in vacuolar proteases.
Dampers of Pressure Fluctuations in the Pipeline Systems of Power Plants and Production Machines
Authors: Chernov N.S.
Published: January 2020

Problems and ways to reduce pressure fluctuations in the piping systems of power plants and production machines are considered. The theoretical foundations of vibration damping are described. The developed device designs are given to reduce pressure fluctuations in pipeline systems. Studied and experimentally tested their effectiveness in comparison with foreign counterparts. The use of designed and implemented dampers to reduce noise and vibration, increase the efficiency, reliability and service life of industrial equipment, prevent fire hazard.
The Use of Frozen Colloidal Sediments of Sludge-Lignin of OJSC "Baikal Pulp and Paper Mill" as Soil
Authors: Bogdanov A.V. , Fedotov K.V. , Shatrova A.S. , Popova G.G.
Published: January 2020

A series of industrial experimental tests on the freeze treatment of colloidal sludge lignin precipitates was carried out under natural conditions. Changes in the physical and chemical properties of the precipitates were studied. It is established that three fractions are formed following the freeze treatment of colloidal sludge lignin precipitates, including demineralized water (up to 25 %), mineralized water (up to 15 %) and a restructured colloidal precipitate (up to 60 %). The total volume of the precipitate is shown to decrease to 40 %. Freezing precipitation of colloidal lignin slurry of "the Baikal Pulp and Paper Mill" leads to a decrease in toxicity from the third to the fifth class of danger. On the basis of frozen sediments, the lignin sludge of OJSC Baikal Pulp and Paper Mill with the addition of other waste from the Baikal region, a fertile soil was obtained that corresponds to GOST R 54651-2011 "Organic fertilizers on the basis of sewage sludge. Specifications".
Justification for the Reclamation of Rock Dumps and Reclaimed Ore Deposits in the Yakutia Diamond Deposits
Authors: Zen’kov I.V. , Kiryushina E.V. , Morin A.S. , Vokin V.N. , Mironova Zh.V. , Kondrashov P.M. , Fedorov A.B. , Veretenova T.A.
Published: January 2020

The results of remote monitoring of the ecological state of waste dumps and storages of processed diamond-bearing rock are presented. Low rates of restoration of vegetation cover at these objects of the mining landscape, formed during the development of kimberlite pipes, were revealed. To accelerate the restoration of vegetation on the territory of disturbed lands, a set of special works on technical and biological reclamation is proposed.
Assessment of the Suitability of Vegetation Indices to Identify Soil and Ecological Condition of the Surface of Anthracite Deposits Dumps
Authors: Sokolova N.A. , Gossen I.N. , Sokolov D.A.
Published: January 2020

The plant and soil cover of the dumps of strongly metamorphic rocks of the Gorlovsky anthracite deposit (Novosibirsk region) has been studied. The link between calculated bonite points and the NDVI and SAVI research indices has been revealed. It has been established that the soilecological state of man-made landscapes, composed by highly metamorphic rocks, has a significant impact on the way of surface formation. It is shown that the young planned areas of dumping dense rocks are characterized by an unsatisfactory soil-environmental condition.
A Study and Evaluation of the Opinions of Seyyid Abul-Fazl Burqe’i
Authors: Mohammadi-Fam Fereydun , Ehsani Keyvan , Nabavi Seyyedmajid
Published: January 2020

Sayyid Abul-Fadl Burge’i is one of the Shiite clerics who was born in 1287 and died in 1372. His life has two phases, in the first stage, until the age of 45, there are seen less materials written by him against the Shia, but in the second stage, after about 45, he has expressed very harsh things against the Shia. In this article, the views of Burge’i are evaluated. He denied this Shiite belief that God Himself has appointed the Imam and introduced him to people by the Prophet (peace be upon him). According to Qur'anic reasons and traditions, his opinions are incorrect. He rejected recourse (Tavassul), intercession (Shifa’at), and pilgrimage (ziyarat), but there are many verses and reasons to prove them which are mentioned in the present article. He wrote a book titles “Scientific Studies on the Hadiths about Mahdi” and in it rejected the hadiths this is while the Prophet (peace be upon him) has said that the one who denies Mahdi has denied me. Finally, it should be said that after investigations we conclude that Burge’i’s views are incorrect and the Shiites do not accept his views.
Technological Perspective for Reducing Emissions from Marine Engines
Authors: Hoang Anh Tuan , Pham Van Viet
Published: January 2020

Climate change and adverse impacts on the ocean environment have recently received much attention in the shipping and marine economic sectors. Preventing pollution of the marine environment from land sources through the river or atmospheric water is only possible by applying clean industrial technologies without waste and methods for rational use of natural resources. Main technical facilities to protect the sea environment from the current pollution are used to remove toxic substances from waste sources of ships. The International Maritime Organization increasingly tightens regulations on emissions with marine transport fleets, especially emissions of NOx and SOx. Therefore, many countries in the world continually improve and develop marine diesel engines in the direction of reducing emissions with different technologies. It is a tremendous necessary to enrich the technological knowledge to select new energy equipment in shipbuilding because they play a vital role in ensuring emission standards throughout the life of the ship. Indeed, technology development orientation in coastal countries' marine industry with the initial study results on the use of extraction optimization measures, alternative fuels, and output emission control solutions, it shows that we can implement some technologies to achieve NOx and SOx reduction according to IMO regulations. This paper summarizes the most important recent development technologies in the world in the field of marine engines. Also, the authors assessed the possibility of applying these new technologies to fleets of coastal countries to meet environmental requirements.
The Application of Clay Pot for Moisture Reduction of Geniotrigona thoracica Stingless Bee Honey
Authors: Mohamad Ghazali Nashratul Shera , Yusof Yus Aniza , Nyuk Ling Chin , Othman Siti Hajar , Abdul Manaf Yanty Noorzianna , Mohd Baroyi Syahrul Anis Hazwani
Published: January 2020

Geniotrigona thoracica (G. thoracica) stingless bee honey contained high moisture that can easily lead to fermentation process. The high moisture content of stingless bee honey could lead to unwanted fermentation and crystallization form. Hence, it will affect the quality of honey in terms of acidic taste and undesirable appearance.  To make sure stingless bee honey meets the standard set by IHC, some methods have been carried out to reduce its moisture content.  This study investigates the moisture reduction during storage of G. thoracica stingless bee honey in a clay pot. The G. thoracica honeys were stored in clay pot with the inner volume of 75.4cm3 and glass bottle (as control) at 25ËšC for 21 days. Physicochemical analysis of honey such as moisture content, total soluble solid, water activity, viscosity, pH, free acidity, electrical conductivity, colour (L*, a* and b*) and colour intensity were investigated during storage. The result obtained indicated that the honey stored in a clay pot was significantly reduced the moisture content from 28.03% to 16.51%. The water activity (aw) of honey in a clay pot was also reduced from 0.779 to 0.601. The free acidity of honey stored in a glass bottle increased significantly compared to honey stored in a clay pot, which was initially 106.7meq/kg to 146.3meq/kg and 121.7meq/kg, respectively. In conclusion, the application of clay pot as a storage medium was capable to reduce water content and preserved the quality of honey from G. thoracica.
Dipeptidyl Peptidase IV (DPP-IV) Inhibitory Activity of Ultrafiltration and Gel Filtration Fraction of Gelatin Hydrolyaste Derived from Bone of Fish for Antidiabetes
Authors: Atma Yoni , Lioe Hanifah Nuryani , Prangdimurti Endang , Seftiono Hermawan , Taufik Moh. , Mustopa Apon Zaenal
Published: January 2020

Bioactive peptides have been investigated largely for many biofunctional properties. The aim of this research was to determine the inhibitory activity of ultrafiltration (UF) and gel filtration (GF) fractions of gelatin derived from bone of Pangasius catfish against dipeptidyl peptidase IV (DPP-IV). Previous studies have shown that gelatin from skins of salmon, hake, halibut, milkfish, tilapia and bone of pangasius catfish have the activity in DPP-IV inhibition. While, as inhibitor, most of previous and recent studies shown that separation and fractination of gelatin hydrolysate increase their activity. This research was conducted in three stages including gelatin hydrolysates fractination by ultrafiltration (UF), UF fraction loaded into gel filtration (GF) and DPP-IV inhibition measurement. The fish bone gelatin was hydrolyzed using flavourzyme at three enzyme/substrate ratios (E/S of 3%, 6% and 9%) with incubation times 4, 6, and 8 h. Then, the hydrolysates fractioned by ultrafiltration with 3 kDa cutoff membrane continued with Superfine G-25 sephadex column (65 cm x 3 cm, flow rate 1 mL/min). The result shown that both group of fractions i.e UF and GF have inhibitory activity regarding their capacity to inhibit DPP-IV.  The UF fraction >3 kDa derived from 9% (E/S) ratio for hdyrolysis were superb as DPP-IV inhibitor than other fractions, the highest one also has bioactivity higher than other previous fish gelatin fractions.
Construction Industry Ignorance to Disaster Risk Reduction
Authors: Prihantony Des Indri , Afrizal - , Hadiguna Rika Ampuh , Ophiyandri Taufika
Published: January 2020

Although experts have identified ignorance as one of the problems in implementing disaster risk reduction, studies on this subject are still relatively small. This paper aims to explore the concept of ignorance about disaster management and construction project management. Ignorance arises as a result of differences in characteristics between disaster management and infrastructure project management about disasters. Disaster management focuses on the issue of uncertainty while construction project management is accustomed to ensuring everything through detailed calculations to optimize limited resources. In contrast, construction project management handles problems through short or medium term solutions while disaster management usually talks about long-term and continuous programs. These differences lead to different perspectives and create mental-blocked for construction industry players to implement disaster risk reduction. Ignorance is also influenced by personal factors, namely motivation and intention. Motivation can be either internal or external. The internal motivation is related to personal pleasure, interest, comfort, and satisfaction while the external one is related to somebody’s efforts to achieve specific goals, getting awards, avoiding punishment or other negative consequences. This paper shows that currently the relationship between the construction industry management and disaster management focuses more on technical and policy aspects. That is the reason why this paper suggests that construction industry player also needs to learn about human behaviors in order to understand the conflicts that might arise between the two due to the personal factors of the actors. These three subjects are similarly essential and complementary to each other. Ignorance to disaster risk reduction is a product of human behavior. Therefore, ignoring the human-interest subject will make the construction industry player having difficulties in implementing disaster risk reduction concept.
Petrological Characteristic and Whole Rock Geochemistry of Metamorphic Rocks in Melangè Complex of Ciletuh Area, West Java, Indonesia
Authors: Ikhram Rinaldi , Syafri Ildrem , Rosana Mega Fatimah
Published: January 2020

Melangí¨ Complex of Ciletuh Area, West Java, Indonesia is located at 106 ° 23 '38.9 "- 106 ° 25' 27.6" E  and 7 ° 14 '27.6 "- 7 ° 12' 46.2" S. This area has unique geological features where the Early Cenozoic uplifted subduction rocks such as ophiolites and metamorphic rocks are exposed. This study aimed to determine the condition of the stratigraphic position and geological structure of metamorphic rock unit in the field, to find out the metamorphic facies and their evolution, to know the parental rocks (protoliths) of metamorphic rocks, and to interpret tectonic environments for the formation of metamorphic rocks based on stratigraphy, geological structure, petrography, and geochemistry. Study of literatures, geological mapping, petrology and geochemical analyses were used as methods of this research. The entire analysis is combined as a guidance in interpretation of petro-tectonic environment. Distribution of metamorphic rock outcrops found in several places, such as, Citisuk River, Cikopo River and Cikarikil River. Based on petrography analysis, metamorphic rocks types consist of schistose amphibolite, various type of greenschist, phyllite and quartzite. The protolith of metamorphic rocks in Ciletuh is quite diverse, namely metasediments such as pelitic, psammitic, calc-silicate sediment, and meta-igneous such as gabbro and basalt. The presence of epidote, chlorite, and calcite in schistose amphibolite show retrograde metamorphism process in lower temperature-pressures condition. The occurance of quartz and calcite vein in several samples was shown as an indication of hydrothermal alteration. Based on geochemical characteristics, the result showed that sedimentary source of metasedimentary rocks were derived from the volcanic arc environment. While, metabasalt rocks were originated from the Island Arc tectonic environment. According to the association, these metamorphic rocks were formed by regional metamorphism, as the result of subduction process and orogenic event. Thus, retrograde metamorphism indicates the lifting or accretion process that caused by subsecuent tectonic activity.
Research and Development of Feature Extraction from Myanmar Palm Leaf Manuscripts for the Myanmar Character Recognition System
Authors: Soe Nwe Nwe , Htay Win
Published: January 2020

This paper proposed Myanmar palm leaf manuscript handwriting OCR system. Each text area in the Myanmar palm-leaf manuscript is segmented. This segmented character text image is needed to be recognized to transform to Myanmar handwritten characters which express Myanmar’s precious historical and invaluable information. This paper involves two essential steps: preprocessing and feature extraction. The preprocessing is carried out to extract the attractive palm-leaf manuscript region from the Images automatically are taken by the camera and to support the enhanced images for subsequence processes of Myanmar character recognition from Myanmar palm leaves. The one-dimensional segmentation approach is used to crop leaf area in the image which is taken with high resolution. Line count analysis is also done to extract the region for using enough line count. After that, line segmentation is carried out using Object Frequency Histogram along the horizontal lines which can find the best optimal points between the lines. Similarly, the same technique but vertically is used to get each character or smallest group of characters. Totally 18 features are extracted to recognize the Myanmar palm-leaf manuscript characters. Although the experimental results are good enough but some difficulties are still needed to take account related to the connected components.
Measuring the Substitution of Vegetable Waste Fermented Rumen Fluid with Tofu Waste in Vannamei Shrimp Feed
Authors: Murni - , Haryati - , Sonjaya Herry , Aslamyah Siti
Published: January 2020

Vannamei shrimp cultivation in Indonesia deals with the complication at high feed fees as a result of raw material feed protein sources. Rumen fluid fermented vegetable waste has the potential to substitute tofu in feed Litopenaues vannamei. This study aims to determine the substitution of vegetable waste with the rumen fluid fermented tofu is best to improve the performance of vannamei shrimp growth. Research carried out for 60 days with evaluation substitution levels of rumen fluid fermented vegetable waste with tofu in vannamei shrimp feed. designed using a completely randomized design (CRD) with 4 treatments each with 3 replications, thus totaling 12 experimental units. Feed treatment tested is A) 0 (control), B) 33.33, C) 66.67, D) 100% rumen fluid fermented vegetable waste.  The results showed that the substitution of tofu with fermented vegetable waste rumen fluid in vannamei shrimp feed a significant effect (P <0.05) on digestive enzyme activity, total and nutrient digestibility, growth, and survival rate of vannamei shrimp. The research shows that the tofu substitution more than sixty percent of fermented vegetable waste could improve feed efficiency to more than a quarter of vannamei shrimp growth. Tofu substitution of rumen fluid fermented vegetable waste in feed could increase the activity of digestive enzymes, total digestibility, nutrient digestibility, growth, and survival of juvenile vannamei shrimp.
A Fuzzy Case-Based Reasoning Model for Software Requirements Specifications Quality Assessment
Authors: Mostafa Salama A. , Gunasekaran Saraswathy Shamini , Khaleefah Shihab Hamad , Mustapha Aida , Jubair Mohammed Ahmed , Hassan Mustafa Hamid
Published: January 2020

Different software Quality Assurance (SQA) audit techniques are applied in the literature to determine whether the required standards and procedures within the Software Requirements Specification (SRS) phase are adhered to. The inspection of the Software Requirements Specification (iSRS) system is an analytical assurance tool which is proposed to strengthen the ability to scrutinize how to optimally create high-quality SRSs. The iSRS utilizes a Case-Based Reasoning (CBR) model in carrying out the SRS quality analysis based on the experience of the previously analyzed cases. This paper presents the contribution of integrating fuzzy Logic technique in the CBR steps to form a Fuzzy Case-Based Reasoning (FCBR) model for improving the reasoning and accuracy of the iSRS system. Additionally, for efficient cases retrieval in the CBR, relevant cases selection and nearest cases selection heuristic search algorithms are used in the system. Basically, the input to the relevant cases algorithm is the available cases in the system case base and the output is the relevant cases. The input to the nearest cases algorithm is the relevant cases and the output is the nearest cases. The fuzzy Logic technique works on the selected nearest cases and it utilizes similarity measurement methods to classify the cases into no-match, partial-match and complete-match cases. The features matching results assist the revised step of the CBR to generate a new solution. The implementation of the new FCBR model shows that converting numerical representation to qualitative terms simplifies the matching process and improves the decision-making of the system.
Object Detection in X-ray Images Using Transfer Learning with Data Augmentation
Authors: Galvez Reagan L. , Dadios Elmer P. , Bandala Argel A. , Vicerra Ryan Rhay P.
Published: January 2020

Object detection in X-ray images is an interesting problem in the field of machine vision. The reason is that images from an X-ray machine are usually obstructed with other objects and to itself, therefore object classification and localization is a challenging task. Furthermore, obtaining X-ray data is difficult due to an insufficient dataset available compared with photographic images from a digital camera. It is vital to easily detect objects in an X-ray image because it can be used as decision support in the detection of threat items such as improvised explosive devices (IED’s) in airports, train stations, and public places. Detection of IED components accurately requires an expert and can be achieved through extensive training. Also, manual inspection is tedious, and the probability of missed detection increases due to several pieces of baggage are scanned in a short period of time. As a solution, this paper used different object detection techniques (Faster R-CNN, SSD, R-FCN) and feature extractors (ResNet, MobileNet, Inception, Inception-ResNet) based on convolutional neural networks (CNN) in a novel IEDXray dataset in the detection of IED components. The IEDXray dataset is an X-ray image of IED replicas without the explosive material. Transfer learning with data augmentation was performed due to limited X-ray data available to train the whole network from scratch. Evaluation results showed that individual detection achieved 99.08% average precision (AP) in mortar detection and 77.29% mAP in three IED components.
Notas sobre a trajetória do decrescimento: origens, concepções e proposições
Authors: Do Nascimento Elimar Pinheiro , Tasso João Paulo Faria
Published: January 2020

Há quase meio século discute-se a finitude dos recursos naturais e a irracionalidade de sua exploração pelo modelo econômico vigente que resultou na presente crise ecológica. Este artigo discute o Decrescimento, uma das saídas propostas à esta crise. Nome propositalmente antipático para que o establishment não se aproprie, como ocorre com o Desenvolvimento Sustentável. O objetivo é desenhar a trajetória do Decrescimento para identificar as possibilidades e limites. Pesquisaram-se as principais publicações que sustentam a proposição. As origens do Decrescimento são múltiplas, tanto de caráter econômico como cultural e as proposições são variadas. Contudo, há três certezas: a ideologia do crescimento, que rege o presente modelo econômico, caso não seja modificado, nos levará a uma catástrofe; medidas paliativas, como as propugnadas pelo Desenvolvimento Sustentável, não conduzem a uma solução da crise ecológica; a saída possível é quebrar a lógica da ideologia do crescimento, buscando uma vida mais simples, com relações sociais mais agradáveis e melhor distribuição, e redução, dos bens materiais. O artigo finaliza perguntando-se sobre a possibilidade de as propostas do Decrescimento serem levadas a cabo, e quais os seus obstáculos.Palavras-chave: Desenvolvimento Sustentável. Decrescimento. Crise Ambiental.
Gül Yetiştiricilerinin Sosyo-ekonomik Nitelikleri ve Kullandıkları Bilgi Kaynakları: Isparta İli Örneği
Authors: ÇELİK ATEŞ Hacer , DOĞUTAŞ Ahmet Umut
Published: January 2020

Amaç: Bu çalışmada gül
yetiştiricilerinin sosyo ekonomik özelliklerini belirleyerek , yetiştiricilerin
yararlandıkları bilgi kaynaklarını ortaya koymak amaçlanmıştır.

Materyal ve Metot: Isparta
İlinde en yüksek
üretim alanı ve yetiştirici sayısına sahip Keçiborlu, Gönen ve Merkez İlçeleri
araştırma bölgesi olarak ele alınmıştır. Örnek hacminin belirlenmesinde ise
basit tesadüfi örnekleme yöntemi kullanılmış ve
örnek hacmi 152 olarak bulunmuştur. Verilerin analizinde oransal dağılımlar, khi kare ve Multiple
Correspondence Analizleri (çoklu uyum analizleri) kullanılmıştır.

Bulgular : Gül
yetiştiricilerinin yaş ortalamalarının 45.7, büyük bir çoğunluğu erkek (%92.1),
eğitim seviyesi lise ve üniversitedir (%54.9). Hane halkı sayılarının
ortalaması 3.1’dir. Gül yetiştiricilerinin meslek dağılımında ilk sırayı çiftçi grubu (%32.9)
almaktadır. Bunu sırasıyla serbest meslek (%20.4), işçi (%19.7) ve memurlar (%14.5)
izlemektedir. Gül ile ilgili en işe yarar bilgiyi  yetiştiricilerin %67.8’inin aile büyükleri,
akraba veya komşu üreticilerden, %20.4’ünün zira ilaç bayilerinden, %7.2’sinin
tarım il/ilçe müdürlüklerinden ve %4.6’sının özel danışmanından aldığı tespit
edilmiştir.MCA analizine göre gül yetiştirmeye devam edecek yetiştiriciler,
lise mezunu ve 31-45 yaş aralığındadır.

Sonuç: Araştırma sonucuna göre,
gül yetiştiricilerinin bir sorunla karşılaştıklarında ilk başvurdukları bilgi
kaynağı zirai ilaç bayileri olmaktadır. Ancak en yararlı bilgi kaynağı olarak
ilk sırada aile büyükleri/akraba/komşuyu, ikinci sırada zirai ilaç bayilerini, üçüncü
sırada ise Tarım il/ilçe müdürlüklerini görmektedir. Zirai ilaç bayilerinden  edindikleri bilginin beklenen faydayı
göstermediği ve yetiştiricileri tatmin etmediği, ayrıca kamunun bilgi kaynağı
olarak gerilere düştüğü ortaya çıkmıştır.
The Unusual Presentation of Acute Pericarditis Mimicking Acute Coronary Syndrome
Authors: Intan Ryan Enast , Octora Tan Nicko , Alkaff Firas Farisi , Balti Dimas Rio
Published: January 2020

Pericarditis is a common disorder that might present in various settings, including primary-care and emergency department. However, the clinical features in some cases did not match with the written theory, which could lead to a misdiagnosis. A 46-year-old man presented to the emergency room with progressive tightness chest pain, epigastric pain, nausea, and vomiting in the past 2 days. Based on the clinical, electrocardiograph (ECG), and laboratory evaluation, the patient was diagnosed with unstable angina pectoris and treated accordingly but did not showed an improvement. Clinical re-examination and echocardiography evaluation showed a pathognomonic finding of pericarditis feature. Combination therapy of colchicine and ibuprofen was given for 3 weeks. One-month follow-up evaluation showed normal ECG and echocardiography result without any remaining symptoms. Acute pericarditis does not always show typical finding. Therefore, clinician must always aware with other differential diagnosis of chest pain and ECG variation of acute pericarditis.
Cognitive flexibility and problem-solving in patients with bipolar disorder
Authors: Nugroho Maria Yosepha Safira , Daeng B. Handoko , Waworuntu Gladdy L.
Published: January 2020

Introduction: This study focuses on the cognitive impairment in patients with bipolar disorder and also the distribution of cognitive flexibility and problem-solving by degree of education, chronicity, and episode of patient is in at the time of evaluation.Methods: This was a cross sectional descriptive study with purposive sampling method. The population was the Harmony in Diversity Group in Surabaya, Indonesia. Twenty-two patients agreed to be subjects and each of them finished the Wisconsin Card Sorting Test (WCST) to measure cognitive flexibility and the Tower of London (TOL) to measure problem-solving. Results: The WCST score are below normal for 90.9% of the patients. Higher cognitive flexibility is found in patients with bachelor’s degree and euthymic patients, while lower cognitive flexibility is found in patients in depression episode, manic episode, and mixed episode. No patients could finish the TOL within the minimum required steps. Better problem-solving is found in patients in manic episode and euthymic patients while lower problem-solving is found in mixed episode and depressive episode.Conclusion: The cognitive flexibility and problem-solving in patients with bipolar disorder are lower than the normal cut off. The type of episode and chronicity are contributing factors. Euthymic patients tend to have better cognitive flexibility and manic patients tend to have better problem-solving ability.
Association Between Neopterin Levels and Outcome in 30 Day HIV/AIDS Naive Patients
Authors: Juanita Lydia , Hadi Usman , Arfijanto Vitanata
Published: January 2020

Introduction: HIV/AIDS is still a major problem throughout the world even in Indonesia. Some markers can provide information regarding the description of immune activity in HIV/AIDS. Neopterin produced by macrophages as a catabolic result of Guanosine Triphosphate (GTP) is one of them. Neopterin has been widely studied as a prognostic indicator of the course in HIV/AIDS. Until now there have been no studies examine the association between neopterin levels and outcomes in 30 days of HIV/AIDS patients.Methods: A prospective longitudinal analytic study involved 56 samples of HIV/AIDS naive patients from January to April 2019. Serum neopterin levels were measured by the Enzyme Linked Immunosorbent Assay (ELISA) method. Outcome is a living condition or death within the first 30 days of the patient being treated. Discriminant function analysis was used to determine the association between variable and controlling confounding factors using the "R" program. Outputs of p value was significant if <0.05.Results: The average age of the study subjects was 39.7 ± 11 years old with predominantly male gender (71.4%). The median serum neopterin level of the study subjects was 168.13 nmol/L with the lowest levels of 11.78 nmol/L and the highest level of 196.95 nmol/L. Outcomes were grouped live and died, each group at 50%. There was a significant positive association between serum neopterin levels and outcomes in 30 days (p=0.02)Conclusion: Role of neopterin levels still need to be proven as a prognostic factor by evaluating other factors that influence the outcome of HIV/AIDS patients.
Correlation between Serum IL-6 Level and Th17/Treg Ratio with Systemic Lupus Erythematosus Disease Activity
Authors: Familia Adidia Carina , Yuliasih Yuliasih , Rahmawati Lita Diah
Published: January 2020

Introduction: SLE pathophysiology shifted to a new paradigm which emphasizing the imbalance between Th17 and Treg. IL-6 is the main cytokine believed as the regulator of the balance between Th17 and Treg which play a big part in SLE pathophysiology and disease activity. The aim of this study was to determining the correlation between serum IL-6 level and Th17/Treg ratio with SLE disease activity on SLE inpatients of RSUD Dr. Soetomo Surabaya.Methods: This cross sectional study included newly diagnosed SLE patients based on American College of Rheumatology (ACR) 1997 revised criteria and confirmed by rheumatologist. All subjects underwent the same examination and assessment such as  SLE disease activity was scored according to SLAM score, serum IL-6 level measured using ELISA, and Th17/Treg ratio where the expression Th17-Treg detected by flowcytometry method.Results: Thirty female subjects with active SLE had mean age 31,3 ± 10,46 years. The most frequent clinical manifestations were hematologic disorders and arthritis. Serum IL-6 level was significantly elevated in SLE patients compare to healthy subjects (200,61 pg/ml versus 45,9 pg/ml, p =0,028). Th17/Treg ratio were also significantly higher in SLE patients compared to healthy subjects (2,49 versus 1,20, p = 0,31). Th17/Treg ratio significantly correlated with SLE disease activity (r = 0,988; p<0,05). There were no significant correlation between serum IL-6 level with Th17/Treg ratio (r = -0,095; p>0,05) or even SLE disease activity (r = 0,066 ; p>0,05). Conclusion: Serum IL-6 level had no significant correlation with Th17/Treg ratio or SLE disease activity. We found significant correlation between Th17/Treg ratio with SLE disease activity.
Effect of combination of pectin substances on viscosity of their aqueous solutions
Authors: Khatko Z. N. , Titov S. A. , Ashinova A. A. , Kolodina E. M.
Published: January 2020

Viscosity is one of the characteristic properties of pectin substances, as well as other lyophilic colloids. Pectin molecules are easily associated with each other or with large molecules of related substances. This article contains the results of the study of dynamic viscosity, internal friction, thixotropic index of aqueous solutions (1 % and 4%) of various types of pectin substances and their combinations. The article presents the results of the study of the influence of different types of pectin substances and their combinations on the dynamic viscosity of pectin solutions and their internal friction. The analysis of values of dynamic viscosity and friction force depending on the type of pectin substances and their combinations is given. It is established that in cases where information on dissipative processes in pectin structures at low speeds and shear loads is required, it is necessary to rely on data on internal friction, in others - on the given information on their viscosity. The thixotropic index is calculated. It is established that the internal friction in pectin solutions and their dynamic viscosity depend on the type of pectin substances and their combinations. In pectin solutions, the internal friction is maximum for Apple pectin, and the dynamic viscosity – for a combination of citrus pectins with beet. When combining pectins, both indicators are most important for the combination of citrus with beet. The obtained data on the viscosity, internal friction and thixotropic index of solutions of different types and combinations of pectins make it possible to regulate the rheological properties of food systems with the addition of pectin substances.
Modern methods for regulation nicotine containing products
Authors: Gnuchih E. V. , Shkiduk M. V. , Mirgorodskaya A. G. , Matyuhina N. N. , Don T. A.
Published: January 2020

Issues of assessing the content of carbonyl compounds in the aerosol of innovative nicotine-containing products: nicotine delivery systems of various designs (LUXLITE, VON ERL My, iKuu i200) and electric tobacco heating system iQOS, by high-performance liquid chromatography/mass spectrometry. At the international level (CORESTA, ISO/TC 126), a lot of work is being done to create methods for quality control of nicotine-containing products. Requirements for nicotine-containing products are not regulated within the EAEU. The monitoring of world studies to determine the content of toxic and conditionally toxic components of aerosol NSP, carried out using the method of machine Smoking. Vniitti IS developing a methodology for comprehensive evaluation of innovative nicotine-containing products on the basis of modern methods of product quality control. Of particular interest is the determination of the content of carbonyl compounds in the aerosol generated by SDN and ESNT, which started in the laboratory of tobacco production technology within the Eurasian Economic Union. The results of machine Smoking according to the canadian intensive method, ISO method, VNIITTI method, standard and experimental CORESTA methods are analyzed. Developed testing methodology and collection of aerosol-nicotine produce using a laboratory five-CERULEAN Smoking machines SM 405. The technique of quantitative determination of carbonyl compounds using high-performance liquid chromatomass spectrometry LCMS/MS by detection at an electrospray source in the negative polarity mode on analytical equipment was validated: chromatograph Thermo Scientific Dionex UltiMate 3000 and mass spectrometer TSQ Quantiva. Validation of methods for collecting and determining the content of carbonyl compounds (formaldehyde, acetaldehyde and acrolein) in the aerosol of nicotine-containing products of various types allowed to obtain reliable data to establish the potential of innovative products to reduce the risk compared with traditional cigarettes. Experimental data on the quantitative determination of carbonyl compounds in the NSP aerosol were obtained. Further research will focus on the development of evidence-based safety requirements for innovative types of nicotine-containing products.
Study of the effectiveness of supplementary feeding in patients with inherited enzyme deficiency
Authors: Ulyanova L. V. , Ledneva V. S. , Burdina N. S. , Talykova M. I. , Ivannikova A. S. , Kolomackaya V. V.
Published: January 2020

The successful provision of optimal nutrition in children with serious diseases depends on the right diet, as well as the addition of specialized mixtures for its correction. The aim of the study was to study the effectiveness of supplemental nutrition in hereditary fermentopathy (cystic fibrosis) in children. The work included a three-year follow-up of 69 children aged 3 to 15 years suffering from cystic fibrosis. Patients were divided into two groups: 37 patients with cystic fibrosis group 1, receiving a modified version of treatment with additional enteral nutrition and 32 patients with cystic fibrosis group 2, receiving traditional treatment. The study conducted a comparative analysis of changes in trophic status in patients using nutritional support mixture produced in the Russian Federation – "Nutrien-standard"in diet therapy. Laboratory, functional and anthropometric parameters were monitored once a month. A significant increase in the physical development of patients was obtained only in the second year of use in the diet of supplementary nutrition, p<0.05. At the 3rd year of treatment, the results of positive dynamics of nutritional status in both groups were confirmed, while the increase in body mass index in the main group was 6.7%, and in the control group-only 1% (p<0.05). It is noted that the use of this mixture allows to achieve positive dynamics of nutritional status in 27% of patients and in 73% of cases to completely eliminate it. The obtained results prove the expediency of additional use of "Nutrient-standard" mixture in the complex therapy of patients with hereditary pancreatic enzyme deficiency, cystic fibrosis
Features of obtaining the catalyst for the synthesis of carbon nanotubes
Authors: Burakova E. A. , Besperstova G. S. , Neverova M. A. , Tkachev A. G. , Orlova N. V. , Dyachkova T. P.
Published: January 2020

In this paper, the features of obtaining a Co-Mo/Al2O3 catalyst to synthesize carbon nanotubes (CNTs) by thermal decomposition were studied. It was revealed that the duration of the pre-catalyst thermal decomposition stage in the process of developing a metal oxide system has a significant impact on its activity in the synthesis of carbon nanostructured materials by chemical vapor deposition (CVD). It was proved that an effective catalyst for CNTs synthesis can be obtained by through thermal decomposition of the pre – catalyst, without calcination of the metal oxide system. The use of the Co-Mo/Al2O3 catalyst, synthesized in such a way, in the CVD process makes it possible to reduce the cost of synthesized CNTs. Using scanning electron microscopy, it was shown that the size of the grains, and specific surface area of the formed Co-Mo/Al2O3 catalyst depend on the thermal treatment conditions of the pre-catalyst. Under the conditions for the implementation of the pre-catalyst thermal decomposition stage (temperature, volume, duration, etc.), it is possible to contro not only the characteristics of the resulting catalyst (specific surface area, efficiency), but also the characteristics of the CNTs (diameter, degree of defectiveness). In the course of experiments, the optimal modes of implementation of the method for obtaining the Co-Mo/Al2O3 catalyst allowed forming a system with a specific surface area of ~ 108 m2/g. The use of the resulting catalyst in the synthesis of nanostructured materials provides a high specific yield of multi-walled CNTs with a diameter of 8-20 nm and a degree of defectiveness of 0.97.