bluuebunny/crossref_metadata_2025 huggingface dataset:
OLIVER ARAUJO, Joan (2017). Las barreras electorales. Gobernabilidad versus representatividad. Valencia: Tirant lo Blanch
Authors: Belda Pérez-Pedrero Enrique
Published: October 2023

Recensión de la obra: OLIVER ARAUJO, Joan (2017). Las barreras electorales. Gobernabilidad versus representatividad. Valencia: Tirant lo Blanch.
Comentario a las Sentencias del Tribunal Supremo de los últimos cinco años sobre menores extranjeros no acompañados
Authors: Asensio Velasco María
Published: October 2023

Sumario: I. INTRODUCCIÓN.—II. VALIDEZ DE LA DOCUMENTACIÓN QUE PORTAN LOS MENORES.—III. PRESUNCIÓN DE MINORÍA DE EDAD.—IV. PRUEBAS MÉDICAS DE DETERMINACIÓN DE LA EDAD.—V. PROTOCOLO MARCO SOBRE DETERMINADAS ACTUACIONES EN RELACIÓN CON LOS MENORES EXTRANJEROS NO ACOMPAÑADOS.—VI. REFLEXIÓN FINAL.
CASTAÑÓN JIMÉNEZ, Carmen (2017). Régimen jurídico y práctica del juramento en España. Madrid: Centro de Estudios Políticos y Constitucionales
Authors: González Hernández Esther
Published: October 2023

Recensión de la obra: CASTAÑÓN JIMÉNEZ, Carmen (2017). Régimen jurídico y práctica del juramento en España. Madrid: Centro de Estudios Políticos y Constitucionales.
Una necesaria reforma legislativa: La designación de Senadores en representación de la Comunidad de Madrid
Authors: Marañón Gómez Raquel
Published: October 2023

El artículo pone de manifiesto la conveniencia de llevar a cabo lo que se considera una necesaria reforma de una regulación excesivamente simple y que no sirve a los efectos de potenciar la figura de los senadores de designación madrileños como instrumentos de información e integración. Partiendo del análisis de las regulaciones existentes en derecho comparado se proponen modificaciones en aspectos tales como plazos en su elección y duración del mandato entre otros.
Consideraciones sobre el principio del carácter presencial de la Actividad Parlamentaria Comentarios a la STC 19/2019, de 12 de febrero y STC 45/2019, de 27 de marzo
Authors: Marañón Gómez Raquel
Published: October 2023

Reflexión sobre: Consideraciones sobre el principio del carácter presencial de la Actividad Parlamentaria Comentarios a la STC 19/2019, de 12 de febrero y STC 45/2019, de 27 de marzo.
CASTELLS, Manuel (2018), Ruptura. La crisis de la democracia liberal. Madrid: Alianza Editorial
Authors: Álvarez Rodríguez Ignacio
Published: October 2023

Recensión de la obra: CASTELLS, Manuel (2018), Ruptura. La crisis de la democracia liberal. Madrid: Alianza Editorial.
PÉREZ-SERRANO JÁUREGUI, Nicolás (2021). El día que Godzilla tomó el Congreso. Madrid: Congreso de los Diputados
Authors: Marañón Gómez Raquel
Published: October 2023

Recensión de la obra: PÉREZ-SERRANO JÁUREGUI, Nicolás (2021). El día que Godzilla tomó el Congreso. Madrid: Congreso de los Diputados.
Consideraciones sobre la Ley de Presupuestos Generales del Estado a la luz de la doctrina del Tribunal Constitucional.
Authors: González Escudero M.ª Teresa
Published: October 2023

La especial naturaleza de la ley de presupuestos generales del Estado, en cuanto que es el reflejo de una de las concretas funciones de las Cortes Generales que se enumeran en el artículo 66 CE, ha propiciado innumerables pronunciamientos del Tribunal Constitucional que, a lo largo de más de cuarenta años, han ido precisando una amplia y muy interesante doctrina en relación con el ejercicio por las Cortes Generales -y por los Parlamentos autonómicos- de la que podríamos llamar la función presupuestaria. El análisis de esta doctrina permite ver las especialidades de una norma que, si bien es ley, es una ley que goza de una singularidad tal, que su contenido, procedimiento de aprobación y vigencia son peculiares, y requieren de una constante delimitación jurisprudencial, cuya sistematización se pretende en el presente trabajo.
El derecho a la información de los parlamentarios en la jurisprudencia contencioso-administrativa reciente.
Authors: Recoder Vallina Tatiana
Published: October 2023

El derecho de solicitar información por los diputados para poder ejercer las demás funciones que tienen encomendadas es fundamental. En los últimos tiempos su garantía se ha visto reforzada al poder recurrirse presuntos incumplimientos de este derecho ante la jurisdicción contencioso–administrativa lo que, además, permite que se vaya perfilando el contenido de este derecho de forma más detallada.
ROVIRA VIÑAS, Antonio (2020). Escritos de Derecho Constitucional. Madrid: Centro de Estudios Políticos y Constitucionales.
Authors: López González José Luis
Published: October 2023

Recensión de la obra: ROVIRA VIÑAS, Antonio (2020). Escritos de Derecho Constitucional. Madrid: Centro de Estudios Políticos y Constitucionales.
El control de la discrecionalidad en el ejercicio de la potestad reglamentaria a partir de los principios generales del Derecho y buena regulación: nec magis nec minus
Authors: Herce Maza José Ignacio
Published: October 2023

En una dinámica de regulación motorizada, que afecta directamente a los derechos e intereses legítimos de los ciudadanos, conviene reflexionar sobre los instrumentos de control de la potestad normativa de la Administración como poder discrecional. Entre todos los mecanismos de supervisión destaca el papel de los principios generales del Derecho y el novedoso control mediante los principios de buena regulación, que ha de calar hondo en los tribunales para garantizar el control jurisdiccional pleno de los poderes públicos. En este trabajo se reflexionará sobre el uso y abuso de la potestad normativa por parte de los poderes públicos y sus instrumentos de control.
Cuarenta años de Derecho parlamentario autonómico: a propósito del nuevo Reglamento de la Junta General del Principado de Asturias
Authors: Fernández Gutiérrez Marco
Published: October 2023

La aprobación del nuevo Reglamento de la Junta General es motivo suficiente para abordar los cuarenta años de Derecho parlamentario autonómico. Además de explorar los principios cardinales y el recorrido histórico desde 1982, con las primeras manifestaciones de la autonomía reglamentaria y las reformas posteriores, se examina detalladamente el nuevo Reglamento, tanto en lo que tiene que ver con su forma de elaboración como con sus principales contenidos. También se lleva a cabo un intento de abstracción y sistematización en torno a las condiciones necesarias para poder afrontar una reforma reglamentaria. El trabajo concluye con una reflexión sobre los retos y oportunidades que se plantean en el Parlamento contemporáneo.
Improving the Quality of Electronic Stories Used in Kindergarten Curricula
Authors: Gaber Karima
Published: October 2023

The scientific change that the current era is witnessing in the field of informatics and informational development and the implications of that progress in all branches of knowledge imposed new variables that affected all aspects of life, and changed many of its patterns and methods to which society must respond. The future requires people with multiple abilities and skills to be able to communicate with others and interact with the changes of the times through advanced modern technical means until it reaches e-learning, which has become an urgent necessity through which the future is predicted. E-learning aims to provide multiple and disparate sources of information that provide opportunities for comparison, discussion, analysis, and evaluation using electronic media in linking and interacting with the educational system while providing the opportunity for learners to interact instantly electronically with each other on one hand, and between them and the teacher on the other hand through modern technological resources/media. The problem with the research is that the institutions that produce the electronic stories for the kindergarten stage do not adhere to the standards necessary to produce these stories for the kindergarten stage. Therefore, the importance of the research stands out in developing a proposed model for the design and production standards of the electronic story for the kindergarten stage.
The Impact of Social Media Use on Family Relationships: A Case Study of Jazan Region, Saudi Arabia
Authors: Basihi Muhammad
Published: October 2023

This study aimed to identify the reality of family relationships resulting from social media from the point of view of parents of students in Jazan, Saudi Arabia, during the second semester of the academic year (2021/2022 AD). The sample of the study was (489) randomly selected families (5%) of the study population of (9799) parents. The researcher used a questionnaire with (27) paragraphs. A paragraph was divided into three areas, and the validity and stability of the study tools were verified, as the value of the (alpha) coefficient for the overall stability of the questionnaire was (0.88). To identify the results of the study, the following statistical treatments were used: T-test for independent samples, one-way analysis of variance, and calculating frequencies for the reality of family relationships. The study showed several results, the most important of which is: the presence of statistically significant differences according to the income variable, in favor of higher income, and the study did not find differences due to the variables of gender, qualification, age, and number of family members. The researcher recommended the need to remove the barriers between fathers and children, which helps children from the experiences of their fathers in life and guides them, in order to overcome the psychological difficulties that they face in their daily lives.
Serum zinc and calcium level in patients with psoriasis
Authors: Baria Kaniz Fatima , Salamb Md. Tahsin , Tufael  , Hasand Sayed Eqramul , Sunnye Atiqur Rahman
Published: October 2023

The purpose of this study was to measure the serum zinc and calcium levels in psoriatic individuals. The Dhaka Medical College's Biochemistry Department conducted a cross-sectional study from 2021 to 2022, involving 110 participants aged 20-55. Group A included 55 diagnosed psoriasis patients and group B included 55 healthy individuals. Serum zinc and calcium measurements were made using a colorimetric technique. Statistical analysis was conducted using the study's data, using unpaired Student's 't' test for continuous variables, Chi-square test for categorical variables, and Spearman's rank correlation coefficient test for correlation (p> 0.5). When compared to healthy subjects, psoriatic patients' mean SD serum zinc and calcium levels (57.488.86 and 7.600.58, respectively) were substantially lower (p 0.001) than those of healthy subjects (79.427.37 and 8.750.45, respectively). Psoriasis and serum zinc and calcium showed a significant inverse relationship (r = -0.769, p0.001 and r = -0.736, p0.001, respectively). Only low serum zinc (p0.066) and considerably low serum calcium (p0.006) were identified in patients with long-term psoriasis (>5 years). It can be inferred from this study that psoriasis patients had lower serum levels of calcium and zinc. Thus, regular evaluation of these biomarkers may be useful in preventing worse outcomes brought on by hypozincemia and hypocalcemia.
English Vocabulary Board Game for Upper Primary School Students in Small and Medium-Sized Schools
Authors: Jeenpracha Chayakorn , Pongtornvivan Chayanin , Wongsatit Nattanan , Ketmuni Montchatry
Published: October 2023

The objectives of this research were 1) to study the results of using board game to improve English vocabulary for upper primary school students in small and medium-sized schools, and 2) to study the students’ satisfaction after using board game. There were a total of 100 students: 50 students from small-sized schools, and 50 students from a medium-sized school. The samples were selected by using multi-stage sampling method. The research instruments were the English vocabulary board game, pre- and post-tests, a behavior observation form, an interview form, and a satisfaction evaluation form. Frequency, mean, percentage, standard deviation, and t-tests, were used to analyze the data.
The research findings indicated that both small and medium-sized school students' scores were increased after using the board game at the statistically significant level of .001. Additionally, students’ satisfaction was at a high level supported by the observation data and interview results.
Impact of educational technology policies in higher education improvements, challenges and perspectives
Authors: Paredes Bermeo Rosa Olivia , Arteaga Alcívar Yamileth
Published: October 2023

The purpose of this research is to evaluate the impact of educational technology policies in the field of higher education, covering both the progress achieved and the challenges faced, as well as future perspectives. In order to carry out this study, a qualitative methodology has been selected based on the analysis of documents related to information and communication technology (ICT) policies and programs in the educational system, as well as on the research of innovative practices of ICT integration in the teaching and learning process. The results obtained show that, although ICTs have had a substantial impact on the transformation of higher education, significant challenges remain, such as the need to promote greater digital inclusion and to design and implement policies and programs more effectively. Regarding future perspectives, the importance of strengthening ICT-related policies and programs, as well as promoting innovative practices for the integration of these technologies in education, in order to achieve inclusive and high-quality education, is emphasized.
Cybersecurity in 5G networks: challenges and solutions
Authors: Basurto Guerrero Mario Oswaldo , Guaña Moya Javier
Published: October 2023

In the context of the increasing adoption of 5G networks, cybersecurity emerges as a crucial challenge that requires innovative solutions. The objective of this study is to analyze the challenges and propose solution approaches in the field of cybersecurity in 5G networks. To achieve this purpose, a comprehensive methodology was adopted that combined an exhaustive review of the existing literature with a qualitative approach to analysis. The research focused on identifying advanced threats facing 5G networks, the vulnerability of IoT devices, data privacy, and the shortage of cybersecurity experts. The results of this study highlight the need to implement advanced detection and response systems to counter sophisticated threats, as well as the development of specific security standards for IoT devices, including strong authentication and data encryption. In addition, the adoption of end-to-end encryption techniques and data management policies are proposed to address privacy concerns in 5G networks. Collaboration between governments, industry and regulators is positioned as an essential factor in establishing strong regulatory frameworks that balancecybersecurity with privacy rights. Likewise, training and education in cybersecurity, together with the use of automated tools, are presented as strategies to overcome the shortage of experts in the field.
Multiple Intelligences in the students of Secondary Basic Education, from the Guaranda School, Pujilí-Cotopaxi canton
Authors: Sandoval Cárdenas Diana Maricela
Published: October 2023

The study of multiple intelligences within the educational field is important, because it helps students enhance those intelligences that predominate or put into practice others that benefit their integral development. This study aims to determine the level of presence of multiple intelligences in the Middle Basic Education students of the “Guaranda” School in Pujilí canton, in the 2020–2021 academic period. The methodology is framed in the quantitative paradigm, descriptive level and quasi-experimental design, through the application of the Multiple Intelligences Questionnaire for Mackenzie (1999), adapted by Lobo (2011), with the participation of three teachers and 39 fifth grade students, sixth and seventh year. From this, a teaching guide was generated to promote the development of multiple intelligences in students and after its implementation it was found that motivation, their participation in the educational process, their self-esteem and academic performance improved, which significantly benefited tothe learners.
THE ROLE OF THE COST AND QUALITY IN ADDITIVE MANUFACTURING
Authors: Malbašić Slobodan , Nedić Bogdan , Đorđević Aleksandar , Živković Srđan
Published: October 2023

Global competition demands faster and more economically production process, products to be more personalized with modern design, sophisticated and of higher quality. Companies are looking for new solutions and production technologies to achieve these requirements. Although they have been on the market for almost 30 years, it is only in the last decade that additive manufacturing (AM) technologies have reached a certain level of maturity to be accepted in the wide industry. Currently additive manufacturing is in a period of transition from its initial purpose for the rapid prototyping and small series to the serial production of parts. On that path, there are still obstacles that slow it down in the form of costs associated with the production process (machines, materials), the lack of advance process control, traditional approach to R&D, education of engineers and the lack of software integration from design stage to post processing. Main focus of this paper is cost analysis in AM. In this regard paper will give brief overview of some developed cost models which brought significant novelties in the cost models considering the economics of AM and quality. Based on this analysis the paper will present suggestions what should be included in new cost model for production of end usable metal parts produced by PBF technology. Also, some quality inspection methods for AM will be briefly explained.
THE EFFECT OF COMPANY SIZE AND CORPORATE GOVERNANCE MECHANISMS ON PROFIT MANAGEMENT ACTIVITIES IN INDUSTRY 4.0
Authors: Setya Gamaliel Fandy , Nursida Nina , Amalia Nida , Shaddiq Syahrial , Rudi Alhempi R. , Supardin Lalu
Published: October 2023

The purpose of the research is to examine whether firm size, managerial ownership, institutional ownership, independent board of commissioners, and audit committee have an effect on earnings management. The population in this study is coal sub-sector mining companies listed on the Indonesia Stock Exchange for the 2019-2021 periods. The data used is secondary data. The data collection method used is the method of literature study and documentation. The analysis used is multiple regression analysis. The results showed that: 1) the size of the partial variables had no effect and had no significant effect on earnings management; 2) partial managerial ownership, institutional ownership and significant effect on Earnings Management in a positive direction; 3) the partial variable of the audit committee has no effect on Earnings Management.
FOOD PRODUCTS DEFILEMENT ANALYZER USING IOT
Authors: Sakthivel M. , Buvisa D. , GokulaVani B. , Jeyapriya M. , Nithya Sri R.
Published: October 2023

In order to make additional, quick profits, shopkeepers frequently adulterate food today. Foods are adulterated by adding things like ripening mangoes, chalk powder to turmeric, starch to curry powder, papaya seeds to black pepper, and other things. Adulteration is a common practise to increase profits, but it can have extremely harmful effects on people. The qualitative spectroscopic method offers a better way to identify the toxic components in milk and other things. The goal of this research is to develop a low-cost, portable, AI-based, non-destructive sensor system that can be used to detect the adulterant in real-time in order to solve this problem. The users can access a dedicated site with an Iot platform from anywhere to view the adulterant that has been found.In this study, the conductivity and pH meter methods were used to examine the food products in order to determine the degree of adulteration present.
LEADERSHIP IN A YOUTH MOVEMENT AS A TRANSFORMATIVE EXPERIENCE
Authors: Farah Adham
Published: October 2023

This study discusses the social leadership of counselors in youth movements in Israel and its contribution to social engagement, both for themselves and the members of the movements. The study method is qualitative, in which six senior counselors (branch managers) from two major youth movements in Israel participated: The Scouts and BneiAkiva. The study provides a glimpse into the world of youth in Israel who participate in youth movements. The study shows how the quality of leadership of the counselors, empowers and advances social goals and contributes to community engagement from which everyone benefits. The study can contribute to the field of education by perceiving the leader as both a teacher and an educator.
MODEL OF DEVELOPMENT AND IMPLEMENTATION OF IMS
Authors: Sofranac Jovan , Zahar Djordjevic Marija , Petronijevic Vuk , Abadic Nebojsa
Published: October 2023

This paper analyzes how a systemic approach to management can be used to facilitate the development and implementation of an integrated management system (IMS) within an organization. It is argued that every solution for integrating management systems requires two elements: a conceptual model and a supporting methodology. While research on IMS modeling is quite extensive, the development of methodologies for achieving fully integrated systems is still not at a satisfactory level. In the IMS acronym, particular emphasis is placed on the I (path to integration). The label M (Management) refers to the desired level of quality, while S (System) represents the methods and activities necessary to achieve the desired goal. It should be noted that all three concepts are directly related. From the above, it can be concluded that the development of IMS represents a broad field of diverse approaches. The paper presents an original model for the development and implementation of IMS systems, thus providing an approach and a set of criteria for selecting the most appropriate IMS model.
EXPECTATIONS TOWARDS SUPPLIERS IN TERMS OF ENSURING AND IMPROVING THE QUALITY OF PRODUCTS AND PROCESSES
Authors: Urbaniak Maciej , Zimon Dominik
Published: October 2023

The aim of the article is to present current trends in the expectations of producers operating on the B2B market towards suppliers in the field of ensuring and improving the quality of products and processes. The analysis of the literature allows to conclude that the fulfillment of these expectations by suppliers is largely achieved through the implementation of guidelines contained in international organizational standards in the field of quality and environmental management, as well as elements of the Toyota Production System (such as Kaizen, 5S, TPM) or the based on the concept of Lean Management. The results of the empirical research (with the use of the CATI technique) indicate that manufacturing companies that are buyers in their expectations towards suppliers focus mainly on improving the technical quality of products, shortening the time of order fulfillment, reducing operating costs.
THE SUSTAINABILITY TRANSITION FROM QUALITY 4.0 TO QUALITY 5.0. A ROLE OF SUSTAINABLE SPIRITUAL AND INTELLIGENT LEADERSHIP IN THE CREATION OF INTANGIBLE CAPITAL FOR FUTURE
Authors: Arsovski Slavko
Published: October 2023

A world is in process of rapid changing in all areas of living. In all of them exists old and new problems with urgent needs for solving. Transition from Industry 3.0 to Industry 4.0 changed view on industry in 21st century and also there are challenges based on Quality 3.0 and Quality 4.0 concept. In last ten years is developed concept of Japan's „Society 5.0“ which needs Quality 5.0 concept. This is main motive for researching possibility for transition quality into Quality 5.0 concept.In the paper are presented basic information about Industry 4.0 and Quality 4.0 based on new challenges in 21st century. Based on literature and own research is defined concept of Quality 5.0 and ways of transition to Quality 5.0, specially in transition counties as Serbia in next 30 years. The first analysis pointed out that it is possible with using intanagle capital-including smart technologies, smart leadership, smart people and other smart „things“ for achieving smart/integrated quality, quality of life, resilience and all human-centric achivities.The new concept of Quality 5.0 needs new role of leadership (Sustainable, Spiritual, Intelligent Leadership), the new model of the efective transition from Quality 4.0 to Quality 5.0 and creating quality capital needed for the future.
Foundry Coatings - Review
Authors: Milanova Gergana
Published: October 2023

The main purpose of this publication is to present the founding stages of the foundry industry and its fundamental importance to the engineering sector. The second focus is to examine the technology of casting in sand molds and more specifically those based on no-bake process(chemically hardening). The auxiliary materials used for the production of sand molds and their importance for the quality of the final part-casting are examined in detail. Special attention is paid to refractory coatings, and in particular those with graphite filler, because of their wide application. The main chemical parameters are presented and the need to study their geometric and tribological characteristics and their influence on the quality of manufactured castings is emphasized. Until now, the author of the publication has studied the micro hardness, roughness, friability and gas permeability of refractory coatings, for which parameters no previous information on similar tests has been found. The research carried out was financed under phd project No. 222ПД0005-05 – TU Sofia, Bulgaria.
Increase of Wear and Heat Resistance of the AISI 304 Steel Surface Layer by Multi-Pass Nanostructuring Burnishing
Authors: P. Kuznetsov Viktor , V. Kosareva Anna
Published: October 2023

The paper presents the results of experimental studies of the AISI 304 steel disc surface after finishing turning, electropolishing and nanostructuring burnishing after one and five passes of the tool with a natural diamond tip with a radius of 2 mm. It is shown that surface layer nanocrystallization provides for almost complete decomposition of austenite in a layer up to 100 µm thick, an increase in microhardness up to 400...450 HV0.025 and a 3.3-fold reduction in the wear intensity on hardened AISI 1045 steel under conditions of lubrication with industrial oil compared with electropolishing. The content of residual austenite in the surface layer is not more than 5% when the temperature rises to 400°C.
Fostran till svenskhet?
Authors: Dahlstedt Magnus
Published: October 2023

Föräldrarnas aktiva roll i relation till både skolan och elevernas skolutveckling har under senare år lyfts fram som en avgörande fråga i svensk skolpolitisk debatt. Föreliggande artikel handlar om hur tjänstemän och skolpersonal i en mångetnisk stadsdel i Stockholm talar om skolans samverkan med föräldrar. Deras tal domineras i stort av två argumentationslinjer, den ena med fokus på föräldrars språk och kultur, den andra med fokus på föräldrars utanförskap. Dessa argumen- tationslinjer tillhandahåller till synes olika sätt att förstå föräldrar i relation till skolan, men tenderar, sist och slutligen, att förenas i tanken om familjen som orsak till en rad allvarliga samhällsproblem. En slutsats i artikeln är att den “föräldraaktivering” som efterlyses i samtida svensk politik sammantaget tycks äga rum på högst ojämlika villkor. Samverkan mellan skola och föräldrar är i flera avseenden villkorad. Inte bara i den meningen att samverkan många gånger sker på skolans villkor snarare än föräldrarnas. Den bygger dessutom på ett, oftast implicit, antagande om att det med självklarhet är “vi svenskar” som ska “aktivera invandrare”.
La jurisprudence de la Cour interaméricaine des droits de l’homme et les luttes autochtones : le cas des communautés du Chaco paraguayen
Authors: Brunet-Bélanger Andréanne
Published: October 2023

L’auteure s’interroge sur le rôle de la jurisprudence de la Cour interaméricaine des droits de l’homme (CIDH) sur les luttes sociales, en prenant comme cas d’étude le Paraguay et les trois communautés autochtones du Chaco qui ont mobilisé la CIDH pour la récupération de leurs terres ancestrales. L’auteure estime que, malgré les lacunes dans la mise en oeuvre des réparations prévues par les jugements, la jurisprudence de la CIDH demeure essentielle pour les communautés. En effet, dans le cas paraguayen, la jurisprudence de la CIDH fournit des outils juridiques qui peuvent être mobilisés légalement par les communautés, dans un contexte où le droit paraguayen ne permet pas de garantir la protection des droits de la personne. La jurisprudence constitue ainsi un outil dont se saisissent les acteurs de ces luttes pour faire reconnaître leurs droits — tant au niveau matériel (en exigeant que l’État applique les jugements) qu’au niveau symbolique (en donnant une légitimité à leurs discours et actions).
A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis
Authors: Lin Jiamin , Zhang Pingping , Liu Wei , Liu Guorong , Zhang Juan , Yan Min , Duan Yuyou , Yang Na
Published: October 2023

Lipid metabolism plays a critical role in cancer metastasis. However, the mechanisms through which metastatic genes regulate lipid metabolism remain unclear. Here, we describe a new oncogenic-metabolic feedback loop between the epithelial-mesenchymal transition (EMT) transcription factor ZEB2 and the key lipid enzyme ACSL4 (long-chain acyl-CoA synthetase 4), resulting in enhanced cellular lipid storage and fatty acid oxidation to drive breast cancer metastasis. Functionally, Depletion of ZEB2 or ACSL4 significantly reduced lipid droplets (LD) abundance and cell migration. ACSL4 overexpression rescued the invasive capabilities of the ZEB2 knockdown cells, suggesting that ACSL4 is crucial for ZEB2-mediated metastasis. Mechanistically, ZEB2 activated ACSL4 expression by directly binding to the ACSL4 promoter. ACSL4 binds to and stabilizes ZEB2 by reducing ZEB2 ubiquitination. Notably, ACSL4 not only promotes the intracellular lipogenesis and lipid droplet accumulation but also enhances fatty acid oxidation (FAO) and ATP production by upregulating the FAO rate-limiting enzyme CPT1A (carnitine palmitoyltransferase 1 isoform A). Finally, we demonstrated that ACSL4 knockdown significantly reduced metastatic lung nodes in vivo. In conclusion, we reveal a novel positive regulatory loop between ZEB2 and ACSL4, which promotes LD storage to meet the energy needs of breast cancer metastasis, and identify the ZEB2-ACSL4 signaling axis as an attractive therapeutic target for overcoming breast cancer metastasis.ZEB2 activates FAO through transcription of ACSL4ACSL4 regulates lipid metabolism through FAO, promoting breast cancer metastasis Targeting ZEB2-ACSL4 signaling axis inhibits breast cancer metastasisWe describe a novel positive feedback loop between ZEB2 and ACSL4 that results in enhanced cellular lipid storage and FA oxidation to drive breast cancer metastasis.
Neuronal NPR-15 controls the interplay between molecular and behavioral immune responses through the amphid sensory neuron-intestinal axis in C. elegans
Authors: Otarigho Benson , Butts Anna Frances , Aballay Alejandro
Published: October 2023

The survival of hosts during infections relies on their ability to mount effective molecular and behavioral immune responses. Despite extensive research on these defense strategies in various species, including the model organism
Caenorhabditis elegans
, the neural mechanisms underlying their interplay remain poorly understood. Previous studies have highlighted the role of neural G protein-coupled receptors (GPCRs) in regulating both immunity and pathogen avoidance, which is particularly dependent on aerotaxis. To address this knowledge gap, we conducted a screen of mutants in neuropeptide receptor family genes. We found that loss-of-function mutations in
npr-15
activated immunity while suppressing pathogen avoidance behavior. Through further analysis, NPR-15 was found to regulate immunity by modulating the activity of key transcription factors, namely GATA/ELT-2 and TFEB/HLH-30. Surprisingly, the lack of pathogen avoidance of
npr-15
mutant animals was not influenced by oxygen levels. Moreover, our studies revealed that the amphid sensory neuron ASJ is involved in mediating the immune and behavioral responses orchestrated by NPR-15. Additionally, NPR-15 was found to regulate avoidance behavior via the TRPM gene, GON-2, which may sense the intestinal distension caused by bacterial colonization to elicit pathogen avoidance. Overall, this study expands our knowledge of how neuronal GPCRs can simultaneously modulate immunity and behavior. Given the conserved nature of the GPCR and immune signaling pathways studied, the findings contribute to a broader understanding of host defense strategies and mechanism underlining the interplay between immunity and behavior across species.
Escolhas contábeis para o reconhecimento de planos de pensão de benefício definido: uma abordagem das entidades brasileiras
Authors: De Almeida Neirilaine Silva , Lemes Sirlei
Published: October 2023

O objetivo do estudo foi identificar as características corporativas associadas com as escolhas contábeis no reconhecimento dos planos de pensão de benefício definido. Identificou-se três escolhas contábeis (taxa de desconto das obrigações dos planos de pensão, taxa esperada de retorno dos ativos dos planos de pensão e taxa para o aumento de salários dos funcionários) nas demonstrações financeiras de 2010 a 2016, de 50 companhias abertas brasileiras com planos de pensão de benefício definido. Os achados sugerem que as entidades mais endividadas tendem a optar por maiores taxas para o desconto das obrigações dos planos de pensão de benefício definido e que aquelas com maiores índices de MTB tendem a adotar menores taxas de desconto e de retorno para os cálculos atuariais. As evidências indicam que o endividamento e o MTB contribuem para o entendimento das escolhas contábeis utilizadas para o reconhecimento dos planos de pensão de benefício definido das entidades brasileiras.
Research - based technology education – the EDURES partnership experience
Authors:   Rzeszów University of Technology, Faculty of Mechanical Engineering and Aeronautics, Rzeszów, Poland, Wdowik Roman , Magdziak Marek , Dzierwa Andrzej , Ciecińska Barbara , Podulka Przemysław , Litwin Jolanta , Bełzo Artur , Borowiec Artur , Nazarko Piotr , Wiater Agnieszka , Markopoulos Angelos , Hojati Faramarz , Azarhoushang Bahman , Pushchak Iryna , Romanini Mariaelena
Published: October 2023

The paper presents the state regarding practices in teaching at partner universities of the EDURES project and current approaches supporting research-based education. It also presents the needs of various groups of stakeholders formulated on the basis of survey results. Moreover, the paper proposes new methodologies which are useful if research results are implemented in teaching programmes at technical universities (research-based lectures, e-learning, web portal methodologies, wizards, etc). It is finally stated that research-results implementation into teaching processes is possible by the use of various tools and approaches proposed by the EDURES partnership and has a potential to be appreciated by students, academics and external stakeholders.
Exploring the Role of Artificial Intelligence for Augmentation of Adaptable Sustainable Education
Authors: Aggarwal Deepshikha , Sharma Deepti , Saxena Archana B.
Published: October 2023

Artificial intelligence (AI) plays a pivotal role in augmenting adaptable sustainable education in numerous ways, transforming the learning experience for students, educators, and institutions. AI can analyze each student's learning style, pace, and strengths and weaknesses to provide personalized learning pathways and recommendations. Adaptive learning systems can adjust the difficulty level of content in real-time, ensuring that students are challenged appropriately. AI can help institutions adapt their curricula to changing industry needs and societal demands by analyzing labor market trends and adjusting educational offerings accordingly. AI has the potential to revolutionize adaptable sustainable education by tailoring learning experiences, improving educational outcomes, supporting educators, and contributing to the sustainability of educational operations. However, it's important to use AI ethically and thoughtfully, addressing privacy concerns and ensuring that technology complements human teaching rather than replacing it entirely. This paper explores the role of artificial intelligence for augmentation of adaptable sustainable education.
Temperature Induction Response: A Rapid Screening Technique for Thermotolerance in Plants
Authors: Raviteja Doddaghatta H. , Dhanoji M. M. , Kuchnur P. H. , Amaregouda A.  , Begum Yasmeen
Published: October 2023

Global warming is a never-ending disastrous threat to the world and the existence of life. For many years, researchers have been cautioning about the disastrous results on the climate if the world touches average temperatures of 1.5ºC above the pre-industrial levels. High-temperature stress affects the growth and development of crops, Reduced photosynthesis and transpiration lead to lower biomass and increased respiration, leading to faster depletion of stored carbohydrates and reduced growth. Altered mineral nutrition and enzyme activity leads to nutrient imbalance and oxidative stress and eventually lowers yields to significant levels. Thermotolerance is a complex trait, and along with agronomic practices, there is a need for the identification and characterization of genotypes for heat tolerance, which is a prerequisite for crop improvement. Temperature Induction Response (TIR) is a high-throughput means successfully employed for assessing, identifying, and screening crop plants for thermotolerance in different crop species. TIR is based on the principle of the LD50 concept and acquired thermotolerance, which is crop-specific in nature. Hence, this review focuses on the relevance, methodology, standardization, mechanism, utilisation and significance of the TIR technique for crop improvement in different crop species to combat heat stress.
Integrative Weed Management Tactics for Rice (Oryza sativa L.) under Direct-Seeding in Kymore Plateau and Satpura Hills
Authors: Tiwari Shivangi , Mondal Triptesh , Soni Rajul , Naj Iram , Tomar Anamika , Upadhyay V. B.
Published: October 2023

Aims: Weed infestation is the major problem in wide adoption of direct-seeding technology by rice farmers. Integration of herbicides with different manual and mechanical methods only can be a permanent solution of weed problem in direct-seeded rice.

Study Design: Randomized block design was taken with three replications for this field experiment.

Place and Duration of Study: The experiment was carried out during kharif, 2019 at the Experimental Farm of Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur, Madhya Pradesh.

Methodology: The treatments were comprised of eight post-emergence weed management treatments including hand weeding twice at 20 days after sowing (DAS) and 40 DAS, respectively and weedy check treatment. All the treatments were allocated randomly in each replication.

Results: Spraying of bispyribac sodium 10% SC at 25 g a.i. ha-1 at 20 DAS + conoweeder at 40 DAS was best in decreasing the infestation of grassy weeds such as Eleusine indica and Echinochloa colona and a sedge weed, Cyperus rotundus during the crop growing period except hand weeding. But broadleaved weeds such as Alternanthera sessilis and Ludwigia parviflora were controlled more effectively with metsulfuron methyl 10% WP + chlorimuron ethyl 10% WP at 4 g a.i. ha-1 at 20 DAS + conoweeder at 40 DAS than the earlier treatment. Highest grain yield (3155.67 kg ha-1), gross monetary return (Rs 57736 ha-1), net monetary return (Rs 1140 ha-1) and benefit-cost ratio (1.91) were registered under the spraying of bispyribac sodium 10% SC at 25 g a.i. ha-1 at 20 DAS + use of conoweeder at 40 DAS among the chemical and integrative weed control options.

Conclusion: The spraying of bispyribac sodium 10% SC at 25 g a.i. ha-1 at 20 DAS followed by use of conoweeder at 40 DAS could be the best sustainable option to control the weed infestation in direct-seeded rice.
Influence of Seed Cake as Organic Fertilizer on Growth, Dry Matter Production and Root Development of Two Cultivars of C4 Plant, Maize (Zea mays) under Lab Conditions
Authors: Nahar Kamrun , Nitu Sadia Afroz
Published: October 2023

A pot culture experiment was conducted with the C4 plant (Zea mays) in the lab during the period of vegetative growth to evaluate the influence of organic fertilizer in the form of mustard oil seed cake on growth, biomass yield and root development of two maize cultivars, hybrid yellow and hybrid purple. The seed cake fertilizer treatments imposed in the experiment were control (T0), others at 2.6%, 3.5% and 4.4% of soil weight respectively against T1, T2 and T3 treatment. The results indicated moderately elevated seed cake application showed considerable improvement in vegetative growth and the plant biomass components including height and other morphological parameters as leaf numbers, length of leaves, number of node and internodal distance per plant, root yield, fresh weight and dry matter production including the root to shoot ratio of the plants, in both the cultivars and in most of the cases found highest in hybrid yellow compared to hybrid purple. Among the plant components, shoot, root dry weight and root to shoot ratio had the greatest decrease under fertilizer deficiency at control (T0) treatment. Among the different  doses of seed cake applications, the highest values recorded at moderate treatments for  most of the parameters, both at vegetative growth and post harvesting after three months of experiment.

The result shows that morphological parameters, biomass yield and its components of the plant were maximum when fertilized with seed cake at 2.6 % and 3.5% of soil weight in treatments T1 and T2, found to be the perfect doses of fertilizer for the maize vegetative growth and biomass yield compared to T0 and other treatments. So, based on the result it can be concluded that T1 and T2 treatment is the best fertilizer treatment for the hybrid yellow maize yield.
Evaluation of the Antibacterial Activity and Toxicity Properties of Funtumia elastica (Preuss) Stapf. (TSN 30176), Used in Traditional Medicine in Nigeria
Authors: Iloka Brendan C. , Igbokwe Christopher O. , Ike Williams E. , Mahady Gail B. , Adeniyi Bolanle A.
Published: October 2023

Background: The urgent need for new and novel antibacterial chemotherapy to combat the worrisome emergence of antimicrobial resistance necessitated the exploration of medicinal plants such as Funtumia elastica. This study was designed to evaluate the antibacterial activity, acute and sub-acute toxicity studies of Funtumia elastica which is used in the ethnomedical treatment of infections.

Methods: The leaves and stem bark of F. elastica were collected, pulverized, extracted using soxhlet extractor and evaluated phytochemically. Antibacterial activities and Minimum Inhibitory Concentrations (MIC) of the crude extracts were investigated on clinical isolates using agar well diffusion. Bioactive fractions of the dichloromethane extract were obtained through column chromatography and thin layer chromatography. Acute and subacute toxicity studies were evaluated on the dichloromethane extract (DCM) using female Swiss albino mice.

Results: The leaves contain tannins, flavonoids, alkaloids, steroids, saponins, and glycosides while the stem contains tannins and steroids.  The hexane extracts lack activities while DCM and ethylacetate extracts of F. elastica were found to have some degree of activities on tested clinical isolates. Bioactivity guided fractionation of the DCM extract yielded only fraction 2 been active on the clinical isolates at 3.5625mg/mL. There were no signs of acute toxicity at the maximum dose of 5000mg/kg body weight. Biochemical parameters showed no significant changes in the liver enzymes. This infers that the extract might not have any negative impact on the liver with regards to metabolism.

Conclusion: The moderate antibacterial activities of Funtumia elastica extracts justified its ethnomedicinal uses and potential to furnish new antimicrobials.
Fibromyalgia in Patients With Hidradenitis Suppurativa
Authors: Aarts Pim , Aitken Jessie J. , van Straalen Kelsey R.
Published: October 2023

This case-control study compares the prevalence of fibromyalgia between adults with hidradenitis suppurativa and adults with non–pain-related conditions.
Mental Health in a Changing Planet
Authors: Lugo-Candelas Claudia
Published: October 2023

This Viewpoint discusses climate change and its effect on mental health.
Individual-Level Risk Prediction of Return to Use During Opioid Use Disorder Treatment
Authors: Luo Sean X. , Feaster Daniel J. , Liu Ying , Balise Raymond R. , Hu Mei-Chen , Bouzoubaa Layla , Odom Gabriel J. , Brandt Laura , Pan Yue , Hser Yih-Ing , VanVeldhuisen Paul , Castillo Felipe , Calderon Anna R. , Rotrosen John , Saxon Andrew J. , Weiss Roger D. , Wall Melanie , Nunes Edward V.
Published: October 2023

Importance

No existing model allows clinicians to predict whether patients might return to opioid use in the early stages of treatment for opioid use disorder.

Objective

To develop an individual-level prediction tool for risk of return to use in opioid use disorder.

Design, Setting, and Participants

This decision analytical model used predictive modeling with individual-level data harmonized in June 1, 2019, to October 1, 2022, from 3 multicenter, pragmatic, randomized clinical trials of at least 12 weeks’ duration within the National Institute on Drug Abuse Clinical Trials Network (CTN) performed between 2006 and 2016. The clinical trials covered a variety of treatment settings, including federally licensed treatment sites, physician practices, and inpatient treatment facilities. All 3 trials enrolled adult participants older than 18 years, with broad pragmatic inclusion and few exclusion criteria except for major medical and unstable psychiatric comorbidities.

Intervention

All participants received 1 of 3 medications for opioid use disorder: methadone, buprenorphine, or extended-release naltrexone.

Main Outcomes and Measures

Predictive models were developed for return to use, which was defined as 4 consecutive weeks of urine drug screen (UDS) results either missing or positive for nonprescribed opioids by week 12 of treatment.

Results

The overall sample included 2199 trial participants (mean [SD] age, 35.3 [10.7] years; 728 women [33.1%] and 1471 men [66.9%]). The final model based on 4 predictors at treatment entry (heroin use days, morphine- and cocaine-positive UDS results, and heroin injection in the past 30 days) yielded an area under the receiver operating characteristic curve (AUROC) of 0.67 (95% CI, 0.62-0.71). Adding UDS in the first 3 treatment weeks improved model performance (AUROC, 0.82; 95% CI, 0.78-0.85). A simplified score (CTN-0094 OUD Return-to-Use Risk Score) provided good clinical risk stratification wherein patients with weekly opioid-negative UDS results in the 3 weeks after treatment initiation had a 13% risk of return to use compared with 85% for those with 3 weeks of opioid-positive or missing UDS results (AUROC, 0.80; 95% CI, 0.76-0.84).

Conclusions and Relevance

The prediction model described in this study may be a universal risk measure for return to opioid use by treatment week 3. Interventions to prevent return to regular use should focus on this critical early treatment period.