bluuebunny/crossref_metadata_2025 huggingface dataset:
Ankara Celal Bayar Bulvarı’nın karayolu gürültüsü açısından eski ve yeni düzenlemesinin karşılaştırılması
Authors: ÖZÇETİN Zuhal , DEMİREL Füsun
Published: November 2020

Gürültü, insan sağlığını fizyolojik ve psikolojik olarak etkilediği gibi, iş ve eğitim yaşamında da performansı olumsuz etkilemektedir. Gürültünün insan sağlığı üzerindeki etkisinin 55–60 dB düzeyinde oluşmaya başladığı ve 65 dB düzeyinden sonra sağlık sorunları ve davranış bozuklukları meydana getirdiği bilinmektedir. Gürültü problemi tüm Dünya’da mevzuat kapsamına alınarak, önemli denetimler getirilmiştir. Bu kapsamda çalışmada; Ankara’nın en işlek caddelerinden biri olan Celal Bayar Bulvarı’nın alan ölçümleri aracılığı ile eski ve yeni düzenlemesi arasındaki fark ortaya konularak, trafik gürültüsünün analizi yapılmıştır. Seçilen örnek çalışma alanında; 2016 yılına kadar alt geçit olmadan kullanım mevcut olup, 2017 yılında trafik, alt geçit aracılığı ile düzenlenmiştir. Araştırmada; her iki zaman periyodunun belirli aralıklarında, mevzuatlara uygun olarak çevresel gürültü ölçümleri (Lgündüz, Lakşam, Lgece) yapılarak, araç sayımları gerçekleştirilmiş ve elde edilen veriler ile hesaplamaları (Lgag) yapılmıştır. Bu bağlamda, karayolunun alt geçit uygulama öncesi (Mayıs 2016) ve sonrası (Mayıs 2017) mevcut durumu, çevresel gürültü ölçümleri bağlamında değerlendirilerek, analiz edilmiştir.

Celal Bayar Bulvarı üzerindeki mevcut durum değerlendirmesi ile iki noktada (9. ve 10. noktalar) yapılan ölçüm analizleri ışığında; karayolu çevresel gürültü düzeyinin, alt geçit çalışması öncesinde elde edilen sonuçlara göre; azaldığı görülmekle birlikte, her iki zaman diliminde de (2016 ve 2017) gürültü düzeyinin sınır değerlerin üzerinde olduğu tespit edilmiş ve bu bağlamda öneriler geliştirilmiştir.
Asimetrik düz dişli dövme işleminin üst sınır enerji metodu ile analizi
Authors: EYERCİOĞLU Ömer , TAŞ Gülağa , ALADAĞ Mehmet
Published: November 2020

Asimetrik dişliler özellikle tek yönlü güç ve hareket iletiminin olduğu uygulamalarda simetrik dişlilere göre daha üstün performansları nedeniyle tercih edilmektedirler. Asimetrik dişlilerin imalatında, hassas dövmecilik teknolojisinin kullanılması ile profilden kaynaklanan imalat sınırlandırmaların ortadan kaldırılması ve yüksek mukavemete sahip dişlilerin verimli bir şekilde üretilmesi mümkün olacaktır. Bu çalışmada, asimetrik düz dişlilerin hassas dövme işleminde, üst sınır enerji metodu (ÜSEM) kullanılarak dövme yükü ve malzeme akışının belirlenmesi için bir analiz sunulmuştur. Bu analizde, asimetrik dişin süren ve sürülen tarafları 12 şekil değiştirme bölgesine ayrılmıştır. Yapılan analizde, iş parçası malzemesinin isotropik ve homojen olduğu, dövme sırasında pekleşmediği, simetri ekseni boyunca malzeme geçişi olmadığı ve simetri ekseni üzerinde malzeme akış hızlarının eşit olduğunu varsayılmıştır. Bölgesel malzeme akış hızlarının hesaplanması ve enerji denklemlerinin çözümü, Python programlama dilinde geliştirilen bir yazılımla gerçekleştirilmiş ve interaktif bir kullanıcı arayüzü sunulmuştur. Prototip bir asimetrik dişli için dövme deneyleri yapılarak elde edilen sonuçlar üst sınır enerji analizi (ÜSEA ) sonuçlarıyla karşılaştırılmıştır. ÜSEA ile elde edilen dövme yükü değişimi ve malzeme akışı, deneysel sonuçlarla benzer olup maksimum dövme yükü göre %10’un altında bir sapma göstermiştir. Geliştirilen yazılım ile dövme yükü kısa bir süre içerisinde hesaplanabilmektedir. Hesaplanan maksimum dövme yükünün deneysel olarak belirlenenden daha yüksek olması, üst sınır enerji metodunun özelliğinden kaynaklanmakta olup, kalıp tasarımı ve pres kapasitesinin belirlenmesinde emniyetli bölgede kalmak için uygundur.
An Industrial Perspective on Robot Learning
Authors: Wahrburg Arne , Listmann Kim , Enayati Nima , Kirsten René
Published: November 2020

Das Thema „Robot Learning“ erfährt in der akademischen Welt zurzeit große Aufmerksamkeit, insbesondere die Anwendungvon Reinforcement Learning in der Robotik. Aus industrieller Sicht versprechen die rasanten Fortschritte im Bereich Robot Learning verkürzte Inbetriebnahmezeiten, vereinfachte  Programmierung, höhere Produktivität und Kostenreduktionen. In diesem Beitragwird das Potenzial der Technologie hinsichtlich industrieller Anwendungen beleuchtet. Es werden wesentliche Herausforderungen herausgestellt und mögliche Ansätze diskutiert, wie Ergebnisse aus dem Bereich Robot Learning in Richtung industrieller Anwendbarkeit getrieben werden können.
Robotergestützte dermatologische In-vivo-Messungen
Authors: Van de Sand Ron , Szymanski Mateusz , Riekmann Olaf , Stolpmann Alexander
Published: November 2020

Dermatologische In-vivo-Messungen werden bislang größtenteils händisch durchgeführt und unterliegen somit großen statistischen Abweichungen, was die Wiederholgenauigkeit negativ beeinflusst. Eine mögliche Lösung des Problems stellt die Einbindungvon kollaborierender Robotik zur automatisierten Durchführung der Messreihen dar. Allerdings können durch die Vielfalt der verschiedenen Körperoberflächen herkömmliche Robotersteuerungen nur bedingt eingesetzt werden. Daher schlägt dieser Beitrag ein Bildverarbeitungsmodell mit optimierter Regressionsfunktion für die Rekonstruktion von Körperoberflächen vor und zeigt, wie diese bei der robotergestützten Durchführung von In-vivo-Messungen nutzbar gemacht werden können.
Eine Online-Plattform für Digitale Zwillinge
Authors: Scheifele Christian , Verl Alexander , Tekouo William , Belgharda Samir , Mauderer Timo
Published: November 2020

Zunehmend suchen Komponentenhersteller nach Lösungen zur Bereitstellung von digitalen Abbildern ihrer realen Komponenten. Ziel ist es, dass Kunden damit ihre Automatisierungskonzepte virtuell validieren und Steuerungssysteme im  Entwicklungsprozess anhand einer virtuellen Inbetriebnahme eingehend testen und optimieren können. Simulationswerkzeuge für die virtuelleInbetriebnahme bieten mittlerweile vielfältige Schnittstellen zur Einbindung bestehender Teilmodelle bei der Modellierung eines digitalen Zwillings einer Maschine oder Anlage. In diesem Beitrag wird die Online-Plattform „TwinStore“ für den Austausch von Simulationsmodellen zur virtuellen Inbetriebnahme vorgestellt.
Activismo ambiental en los Pedregales de Coyoacán (México)
Authors: Sierra-Martínez Andrés
Published: November 2020

En la actualidad son innegables las consecuencias del deterioro ambiental urbano, teniendo como correlato la emergencia de la protesta social. Este trabajo reflexiona sobre las implicaciones de la protesta y el activismo ambiental urbano en las ciudades. Se utiliza metodología cualitativa para analizar el caso de la Asamblea General de los Pueblos, Barrios, Colonias y Pedregales de Coyoacán (AGPC). El activismo ambiental urbano produce una actualización y reconfiguración del significado de la ciudadanía y del arraigo territorial, contribuyendo a la construcción de alternativas con expectativas de justicia ambiental.
El sistema brasileño de gestión del agua y la participación pública: el caso de la cuenca del río Paraíba
Authors: Alves Oliveira Silva Jose Irivaldo , Melo Ana Paula
Published: November 2020

Millones de personas sufren de escasez de agua en Brasil, lo que puede dar lugar a conflictos por la falta de una adecuada participación pública de los usuarios en la toma de decisiones. El Proyecto de Integración del río São Francisco (PISF) tiene como función principal aumentar el suministro de agua en las ciudades y en las áreas rurales. Este trabajo pretende analizar la participación del Comité de la Cuenca del río Paraíba (CBH-PB) y la gestión de cuencas con la llegada del trasvase, a través del estudio documental, así como verificar el desempeño de los actores que participan en el proceso de discusión dentro del Comité, identificando sus impactos ambientales. Los documentos analizados abarcan un período de tiempo comprendido entre 2007 y 2016. Concluyéndose que no hubo una participación efectiva del Comité en el proceso de toma de decisiones con respecto a las obras del trasvase y del saneamiento.
Resistencias urbanas al cambio climático: Consumo crítico, agroecología y defensa del territorio en Guadalajara, Jalisco, México.
Authors: Regalado Santillán Jorge , Rodríguez Guerrero Rodrigo
Published: November 2020

En el presente artículo se muestra cómo —ante escenarios de crisis— las organizaciones sociales generan resistencias ante aquello que provoca un deterioro ambiental y afecta a la vida de las colectividades, sobre todo en las grandes urbes. Mediante acciones creativas de hacer política, los colectivos aquí presentados logran mantener las posibilidades de una vida digna y sana. Enfocamos nuestro estudio en organizaciones urbanas orientadas al consumo crítico, la agroecología y la defensa del territorio, que actúan en la ciudad de Guadalajara México, y que con sus acciones coadyuvan a disminuir el cambio climático ocasionado por el deterioro ambiental. Al acercarnos a las prácticas de estos colectivos, encontramos que, además de sus acciones concretas, existe un impacto simbólico, con potencial prefigurativo de otros mundos posibles, incluyendo a grupos sociales que han sido marginados y opacados en las grandes urbes.
El activismo urbano frente a la crisis socioambiental y climática
Authors: Gravante Tommaso , Poma Alice
Published: November 2020

Presentación y justificación de la necesidad de este dossier
ASPECTOS RELACIONADOS À INTERNAÇÃO HOSPITALAR EM ADULTOS PORTADORES DE HIV/AIDS
Authors: Silva Cícera Eugenia Pereira , Dolce de Lemos Ligia Mara , Silva Juliana Oliveira Musse , Lima Lidiane de Souza , Teles Maria Josiene Menezes , Guimarães Maria Alzira D’ávila Nery
Published: November 2020

Resumo

Objetivo: analisar aspectos relacionados à internação hospitalar em portadores de HIV/aids. Método: trata-se de um estudo transversal, realizado no Hospital Universitário de Aracaju/SE, no setor de infectologia. Resultados: a amostra foi composta por 40 adultos HIV reagentes. Dos 40 participantes, 24 (60,0%) eram homens, 20 (50,0%) possuíam faixa etária abaixo de 40 anos e 27(67,5%) com menos de oito anos de estudo. Quanto à internação hospitalar 31 (77,5%) apresentaram diagnóstico tardio do HIV, com doenças relacionadas à aids, a exemplo de pneumonia 2 (5,0%) e tuberculose 4 (10,0%). Conclusão: os dados deste estudo permitem afirmar que homens, população jovem e com pouca escolaridade são aspectos que corroboram para a internação hospitalar. A predominância entre os pacientes que apresentaram diagnóstico tardio é preocupante, principalmente por revelar falhas nos processos do cuidado à saúde.

Palavras- chave: HIV; Aids; Hospitalização; Terapia Antirretroviral de Alta Atividade.
COVID-19: UM PANORAMA COM ÊNFASE EM MEDIDAS RESTRITIVAS DE CONTATO INTERPESSOAL
Authors: Garrido Rodrigo Grazinoli , Garrido Fabiola de Sampaio Rodrigues Grazinoli
Published: November 2020

Buscou-se oferecer uma visão geral da pandemia de COVID-19, enfatizando os impactos das medidas de saúde pública restritivas de contato interpessoal propostas pela OMS. Desenvolveu-se pesquisa exploratória, a partir da revisão sistemática de artigos de grande impacto internacional nas ciências médicas, publicados após a decretação pela OMS da COVID-19 como Emergência de Saúde de Âmbito Internacional, em janeiro de 2020. Além disso, buscou-se discutir a problemática gerada por governantes, ao contrariarem as propostas da OMS para interrupção da transmissão. Assim, foi possível reunir e apresentar informações atualizadas sobre a COVID-19 e, principalmente, reconhecer o papel inequívoco no controle da pandemia pelas medidas clássicas de saúde pública.
VARIAÇÃO SAZONAL DE PARÂMETROS FÍSICO-QUÍMICOS NA PORÇÃO ESTUARINA DO MUNICÍPIO DE RAPOSA – MA
Authors: Ferreira do Nasicmento José Elias , Do Nascimento Farias Caíque Matheus , Torres Pires Maria Luiza , Eschrique Samara Aranha , Da Silveira Paula Cilene Alves
Published: November 2020

O sistema estuarino se destaca de outros da zona costeira por sua alta produtividade biológica, sendo um ambiente aberto, que está dominado por processos físicos, químicos e biológicos. A área de estudo abrange uma porção estuarina do Município de Raposa, da qual recebe influência das baías de São José e São Marcos, que compõem o Golfão Maranhense. O objetivo deste trabalho foi determinar a distribuição dos parâmetros físicos e químicos da água, relacionando com os períodos sazonais. As amostras das águas foram coletadas na superfície, realizadas em duas campanhas, abrangendo os períodos de chuva (maio/2017) e estiagem (novembro/2017), com sete pontos de coleta por campanha, totalizando 14 amostras de água, obtidas pela garrafa de van Dorn. Foram determinados os seguintes parâmetros hidroquímicos: profundidade local, temperatura, salinidade e condutividade; a transparência da água; o oxigênio dissolvido e a saturação do oxigênio; pH, totais de sólidos suspensos (TSS) e turbidez. Os valores medianos nos períodos de chuva e estiagem, respectivamente, para os parâmetros medidos, foram: transparência de 3,4 e 4,5 m; temperatura 28,2 e 30°C; salinidade 25,3 e 36,7 g kg-1; pH 7,8 e 8,1; oxigênio dissolvido 2,5 e 5,0 mg L-1; saturação de OD 54,5 e 112,2%; turbidez 13,1 e 36,0 UNT; TSS 42,4 e 136,3 mg L-1. A distribuição dos parâmetros físicos e químicos mostraram diferenças entre os períodos sazonais, principalmente relacionados com os aportes de água doce e marinha, com exceção da temperatura, que foi praticamente constante nos dois períodos.
AVALIAÇÃO INTEGRADA DE ESCORES DE QUALIDADE DE VIDA E ESTRESSE EM PRÉ-VESTIBULANDOS
Authors: Almeida-Santos Marcos Antonio , Carvalho Iza Fontes , Vargas Marlizete Maldonado
Published: November 2020

Este trabalho teve como escopo elaborar uma análise combinada de escores de estresse e qualidade de vida em jovens estudantes de curso preparatório para universidades, mediante a aplicação de modelos de equações estruturais. Foi utilizado o Inventário de Estresse de Lipp (ISSL) para obter os níveis de estresse e o WHOQOL-Bref para mensurar os índices de qualidade de vida. Os resultados revelaram estresse positivo em 68,75% dos sujeitos. Em relação à qualidade de vida, a maior média encontrada foi na autoavaliação (14,13) e a menor foi no domínio ambiental (11,70). Obteve-se uma correlação negativa entre níveis de estresse e qualidade de vida (coeficiente estandardizado = -0.65) para a amostra analisada.
ANÁLISE DAS CAUSAS DA DESATIVAÇÃO DO SISTEMA CURURUCA DE CAPTAÇÃO SUPERFICIAL EM PAÇO DO LUMIAR, MARANHÃO
Authors: Monteiro Fábio Henrique Bezerra , Santos Júnior Moisés Silva , Gonçalves Pollyanna Pedrosa , Vieira Larissa Kelly Nogueira , Silva Neto Manoel Cariolano da , Lindoso Thalissa Cantanhede , Guterres Camila Everton , Pinheiro Nathalia Cunha Almeida
Published: November 2020

A problemática relacionada ao abastecimento de água tem sido amplamente destacada no cenário mundial. Essas dificuldades podem ocorrer devido a inúmeros motivos, por exemplo, os resultados do processo intenso e desorganizado de urbanização e industrialização, de gestões ineficientes e mau planejamento dos recursos hídricos e da infraestrutura inadequada do sistema de abastecimento de água. Diante disso, o presente trabalho indagou por meio de pesquisas realizar um levantamento das possíveis causas que resultaram na desativação do sistema de captação de água do Rio Cururuca, o qual pertence à bacia Santo Antônio, localizado na Ilha do Maranhão nos municípios de São José de Ribamar e Paço do Lumiar. Por meio desse sistema de captação de água que na época contribuía com 312m³.h-1 de água para abastecer o conjunto Maiobão, o mesmo continha 4.666 residências e com uma população acima dos 20.000 habitantes, esse sistema foi interrompido em consequência de sua quantidade e qualidade do recurso hídrico que deixou de serem suficientes para atender às demandas da população que habita a região citada. Através do auxílio do geoprocessamento, foi possível observar através da análise de dados de uma escala temporal que o uso e ocupação do solo de forma desordenada teve uma grande contribuição para o problema abordado.
DESENVOLVIMENTO DE PRIMERS IN SILICO DE Mycobacterium tuberculosis DA REGIÃO 16S PARA O DIAGNÓSTICO DA TUBERCULOSE
Authors: Muniz Herison Victor Lima , Silva Neto Antonio Fialho da , Sales Luiz Alfredo Torres , Soares Thalita Rodrigues , Alves Matheus Silva
Published: November 2020

Mycobacterium tuberculosis é uma bactéria agente causadora responsável por grande parte dos casos de tuberculose (TB), mostrando-se como um grande problema de saúde pública. A TB é uma doença infectocontagiosa que atinge principalmente os pulmões, além de outros órgãos como rins, intestinos e meninges. O objetivo deste estudo foi desenhar e analisar primers de M. tuberculosis strain H37Rv da região 16S do rDNA para fins de diagnóstico molecular da tuberculose pela Reação em Cadeia da Polimerase (PCR). Foi utilizado a plataforma NCBI para obter a sequência completa do gene específico de M. tuberculosis, em seguida, cinco primers foram desenhados pela ferramenta BLAST do NCBI e analisados pela IDT integrated DNA Technologies, utilizando a ferramenta OligoAnalyzer. A partir da análise e desenho in silico dos cinco primers, foi observado que todos eles estavam dentro dos parâmetros estabelecidos. Sendo assim, os primers em teoria são eficientes para amplificar pares de bases e ser útil para o diagnóstico da tuberculose.
PRECARIZAÇÃO DO TRABALHO: ASPECTOS CONJUNTURAIS, FUNDAMENTOS DE SUA GÊNESE E TENDÊNCIAS CONTEMPORÂNEAS
Authors: Barros Albani
Published: November 2020

Este artigo é um estudo teórico a respeito da precarização do trabalho no contexto histórico contemporâneo. Inicialmente, partimos de uma análise que prioriza o aspecto conjuntural como fundamento da precarização. Essa intepretação encontra-se, principalmente, nas obras dos autores Robert Castel e Guy Standing. Em seguida, buscamos examinar a partir de uma perspectiva marxista quais os elementos que estão na gênese da precarização, dando ênfase a explicação contida no capítulo XXIII de O capital, na Lei geral da acumulação capitalista. Por último, apresentamos uma síntese das atuais tendências presentes nas relações de produção, em que a precarização aparece como uma realidade crescente em todo mundo e nos diferentes setores econômicos, manifestada sob diferentes formas de inserção dos trabalhadores em relações marcadas pela fragilidade de vínculos e pela incerteza.
A (IM)POSSIBILIDADE DE RELATIVIZAR O PRINCÍPIO DA RECIPROCIDADE NOS CASOS DE PRESTAÇÃO ALIMENTÍCIA DOS FILHOS COM RELAÇÃO AOS PAIS TENDO EM VISTA O ABANDONO AFETIVO E MATERIAL PRATICADO PELOS GENITORES
Authors: Werle Caroline Cristiane , Goldenberg Stephanie
Published: November 2020

Este trabalho tem como objetivo principal verificar a viabilidade jurídica da relativização da obrigação alimentar dos filhos com relação aos pais nos casos de abandono material e afetivo. Assim, o artigo pretende responder o seguinte problema: é possível relativizar o principio da reciprocidade nos casos de prestação de alimentos dos filhos aos pais em caso de abandono afetivo e material? Trata-se de uma pesquisa bibliográfica e jurisprudencial, desenvolvida através do metodo dedutivo de abordagem. Dessa forma, num primeiro ensejo o artigo fará breves apontamentos históricos sobre o direito de família e a prestação de alimentos. Na sequência, será analisada a obrigação alimentar no ordenamento jurídico Brasileiro. Por fim, o trabalho irá verificar a visão jurisprudencial sobre o abandono material e afetivo e a possibilidade de relativização da obrigação alimentar dos filhos com relação aos pais em face do abandono praticado pelos genitores. Com relação ao objetivo principal do trabalho, este é voltado para demostrar de forma clara o assunto em questão, especialmente porque houveram diversas mudanças no ordenamento jurídico com o passar do tempo no que diz respeito à obrigação alimentar, a qual sofreu influxos dos mais diversos ramos da sociedade.
POLÍTICA PARA MULHERES: UMA ANÁLISE SOBRE AS COTAS ELEITORAIS DE GÊNERO NO BRASIL
Authors: De Souza Azevedo Mariana , Monteiro de Castro Bianca Gomes da Silva Muylaert , Pavan de Souza Frank
Published: November 2020

As cotas consistem em modalidade de ação afirmativa que almeja reduzir as desigualdades sociais existentes. No campo da política, percebe-se majoritariamente a presença masculina, ainda que os debates sobre representatividade feminina nos espaços públicos tenham avançado ao longo do tempo. O presente artigo propõe uma análise sobre a experiência brasileira com as cotas eleitorais de gênero, buscando compreender a escassez de representatividade feminina que ainda existente no cenário atual da política brasileira. O objetivo desse estudo é verificar a eficácia das cotas eleitorais quanto ao crescimento do número de mulheres ocupando o Congresso Nacional. Desse modo, realizou-se análise documental e pesquisa bibliográfica, considerando as contribuições de autores como Miguel (2000), Araújo (1998) e SOUZA (2016), entre outros. Concluiu-se que somente a implementação das cotas eleitorais de gênero não é suficiente para garantir o acesso das mulheres aos cargos políticos, tendo em vista que o histórico de exclusão das mulheres do espaço público ainda persiste, principalmente, nos processos políticos.
A TUTELA DOS DIREITOS DA PERSONALIDADE NA ALEMANHA
Authors: ZANINI LEONARDO ESTEVAM DE ASSIS
Published: November 2020

O presente artigo realiza um breve estudo sobre o regime jurídico dos direitos da personalidade no direito alemão. Trata-se de pesquisa que utiliza metodologia descritiva, baseada fundamentalmente na investigação bibliográfica e jurisprudencial. Os temas mais relevantes da matéria são analisados, como a proteção dada pelo § 823, I do Código Civil alemão (BGB), o direito geral da personalidade, bem como as relações existentes entre o direito geral da personalidade e as previsões relativas aos direitos especiais da personalidade. O estudo deixa claro ao leitor a ideia de cooperação existente entre o direito geral da personalidade e os direitos especiais da personalidade, estes considerados como desdobramentos daquele. Merece ainda destaque a análise dos principais direitos especiais da personalidade: direito à voz, direito à imagem, direito ao nome, direito à honra, direito à privacidade e direito à autodeterminação informacional. Assim sendo, o objetivo desse trabalho não é uma pesquisa histórico e evolutiva dos direitos da personalidade na Alemanha, mas apresentar um breve panorama atual de proteção desses direitos naquele país.
A Didactic Engineering in the Research Process of the Generalization of the Padovan Sequence: An Experience in a Pre-Service Teacher Training Course
Authors: Machado Vieira Renata Passos , Alves Francisco Regis Vieira , Catarino Paula Maria Machado Cruz
Published: November 2020

Background: Obstacles are found during the epistemological construction of mathematical concepts research, aiming to contribute to the Didactics of Mathematics through a study of Padovan sequence.  Objectives: describe elements of a systematic study, based on Didactic Engineering in conjunction with the Theory of Didactic Situations. I addition, referring to the generalization model of Padovan sequence and promoting a historical-evolutionary understanding and its mathematical properties. Design: it presents the most representative data of an investigation supported by the foundations of Didactic Engineering research design, in association with the Theory of Didactic Situations teaching methodology. Setting and Participants: the research was developed in 2019 and applied in a Pre-Service Mathematics Teacher Training Course in the History of Mathematics discipline, with the eight students enrolled. Data collection and analysis: data validation occurred internally due to the short period of the research. Results: it describes an investigation around the object of study, the Padovan sequence, focusing on the generalization process of this sequence and its properties. Thus, three problem situations are elaborated and analyzed based on the assumed research and teaching methodologies, seeking to examine their properties and the student's intuitive thinking, before the insertion of a historical-epistemological conception of this investigation. Conclusions: the research makes it possible to extract repercussions, suggest and promote research scripts aiming at the formation of teachers (initial) in the context of the teaching of History of Mathematics.
Efficacy and safety of cisplatin and paclitaxel (PlaTax regimen) in the neoadjuvant treatment of patients with stage II–III triple-negative breast cancer
Authors: Gordeeva O. O. , Kolyadina I. V. , Zhukova L. G. , Ganshina I. P. , Vyshinskaya G. V. , Kazantseva M. A. , Sukhova M. V. , Ryabishina O. E. , Lubennikova E. V. , Filonenko D. A. , Chichikov E. I. , Polushkina I. N. , Borisova E. I. , Lud A. N. , Meshcheryakov A. A.
Published: November 2020

Background. Treatment results for the patients with stage II–III triple negative breast cancer (TN BC) have to be improved. Not only the new treatment regimens, but new predictive and prognostic factors should to be developed.

Materials and methods. We included 98 patients with stage II–III TN BC in our study. We studied efficacy and safety of PlaTax regimen (cisplatin 75 mg / m2 day 1 + paclitaxel 80 mg / m2 days 1, 8, 15, course every 4 weeks) in this cohort of patients. We assessed pathologic response, survival and factors, which were relevant for predicting response and prognose survival.

Results. PlaTax regimen is characterized by high efficacy and tolerable toxicity. Clinical efficacy was 85.8 %, pCR achievement was 60.5 %, tpCR achievement was 58.1 %. The regimen has low haematological toxicity (neutropenia III–IV grades – 4.1 %); the most frequent adverse events were polyneuropathy (18.5 %) and decreased renal function (24.5 %). 3-year progression-free survival was 68.4 %, most of the relapses (92 %) occurred during first 2 years. 3 year overall survival was 77.6 %. The most relevant predictive factor was level of Ki-67 ≥50 % (pCR 38.5 % vs. 68.7 %, p = 0.038). pCR achievement was the most important prognostic factor, resulting in improved 3-year progressionfree survival (44.3 % vs. 89.1 %, p <0.0001), and 3-year overall survival (61.5 % vs. 91.6 %, p = 0.001). Not only the residual disease, but also the size of residual tumor was important from prognostic point of view. Other important prognostic factors were size of the tumor, status of regional lymph nodes, grade. Delay in surgical treatment more than a month lead to decreased 3-year progression-free survival: 87.1 % vs. 62.5 % (p = 0.047).

Conclusions. Our data suggest that studied regimen could be an option for patients with stage II–III TN BC. The assessment of the predictive and prognostic factors will help improve the treatment results for patients with stage II–III TN BC.
Radio-induced breast angiosarcoma: features of diagnostics and treatment (a clinical case and literature review)
Authors: Kolyadina I. V. , Kometova V. V. , Bikeev Yu. V. , Khokhlova S. V. , Rodionov V. V.
Published: November 2020

Breast angiosarcoma (BAS) is an extremely rare and poorly studied neoplasm, the etiology of primary BAS remains controversial, and secondary BAS is most often radio-induced. Radio-induced breast tumors usually appear 10–20 years after the initial treatment; however, for BAS this period is much shorter and is about 4–7 years. This review presents literature data on the features of the clinic, diagnosis and treatment of BAS, as well as own clinical case observation of radio-induced sarcoma of the left breast, that developed 4 years after the primary breast cancer treatment.
Parathyroid carcinoma. The experience of treatment of 15 patients and a review
Authors: Severskaya N. V. , Ilyin A. A. , Chebotareva I. V. , Zhelonkina N. V. , Polkin V. V. , Isaev P. A. , Derbugov D. N. , Podvyaznikov S. O.
Published: November 2020

Background. Parathyroid cancer (PC) is extremely rare, usually diagnosed after surgery, there are no clinical recommendations for the treatment of metastatic PC.

The study objective is to present the results of a clinical examination and treatment of patients with PC.

Materials and methods. Retrospective analysis of 15 PC patients treated from 2001 to 2019. The results of laboratory tests, the surgical approach, the results of treatment, the rate of metastasis and relapse within 19 months (3 months – 11.6 years) after surgery are presented.

Results. Tumor size is 35 mm (20–45 mm). Lymph node metastases – 1 (6.7 %), distant metastases – 2 (13 %). The median initial parathyroid hormone (PTH) is 735 pg/mL, calcium 3.22 mmol/L. Severe hyperparathyroidism with osteitis fibrosa cystica – in 6 (40 %). The surgical approach was parathyroidectomy in 10 (67 %), en bloc resection in 5 (33 %). Normalization of PTH and calcium after surgery – 13 (87 %). In two patients with distant metastases, the PTH and calcium remained high. A patient with Th6 vertebral metastasis was successfully operated on, with normalization of PTH and calcium, and 1.5 years was without relapse. A patient with lung and liver metastases received sorafenib after surgery, with decrease in calcium level. She died of progression 12 months after operation. Among patients with normalization of postoperative PTH, one had local relapse after 4 years. The patient was re-operated and 1 year after the second operation without relapse. The remaining patients are without relapse/progression.

Conclusion. At the time of diagnosis, lymph node metastases are in 6.7 %, distant metastases – 13 %. Normalization of PTH and calcium after surgery suggests a good prognosis, but does not exclude the recurrence in the future, which requires long-term follow-up. Repeated surgery for local recurrence or solitary distant metastases can provide stable remission. Sorafenib in metastatic PC has managed to control hypercalcemia in the short term, however, antitumor efficacy requires further study.
Does morphology have real impact on local and distant recurrences in head and neck cutaneous melanoma?
Authors: Mudunov A. M. , Pak M. B. , Demidov L. V. , Baryshnikov K. A.
Published: November 2020

Introduction. The term “local recurrence” is usually understood as regrowth of a tumor after surgical treatment. The regrowth appears within 3–5 cm from postoperative cicatrix. The causes for such prolonged tumor growth or recurrence of patients with cutaneous melanoma are nonradical surgical treatment as well as satellite or transit metastases that were not removed in-block with primary tumor. A great number of clinical researches, aimed at examination of melanoma, its patterns, anatomical criteria and features of clinical course, gave an opportunity to separate satellite or transit metastases into an independent group. Such metastases are realized inside or subdermally, up to 2 cm or more than 2 cm from the primary tumor, yet, not reaching the location of the first regional barrier.

The aim of the study is to define influence of the main prognostic factors such as tumor thickness according to Breslow, the level of invasion according to Clark and the presence of ulceration on the frequency of local recurrence with cutaneous melanoma of head and neck.

Materials and methods. The research involved 174 patients with cutaneous melanoma of head and neck (1995–2014). According to our index of contraction of a skin flap (median 30 %) the true borders of resection were clearly defined within all the patients. Thereby, 3 groups were identified with the following resection margin: 1.0 cm, where followed-up treatment results were analyzed.

Results. Progression-free survival didn’t correlate with the size of surgical resection margins. The survival rates were the best with the lowest resection margin under 0.5 cm (77.3 %) and the worst with the highest resection margin more then 1.0 cm (38.7 %). That means that the treatment results don’t depend on the width increase of tumor resection margin.

Conclusions. We consider that clear surgical margins for any thickness of cutaneous melanoma of head and neck should be as follows: 4 mm – 0.72 mm (p = 0.016). In our work, the influence of the main prognostic factors, such as tumor thickness according to Breslow, level of invasion according to Clark and ulceration on the frequency of head and neck cutaneous melanoma local recurrences had no impact.
Survival of patients with salivary gland malignancies depending on the molecular profile of the tumor
Authors: Kutukova S. I. , Imyanitov E. N. , Raskin G. A. , Ivaskova Yu. V. , Belyak N. P. , Yaremenko A. I. , Razumova A. Ya. , Baykalova P. M.
Published: November 2020

Introduction. Standard methods of drug or radiation therapy administration for salivary gland cancer is the least successful for now. Therefore, the identification of new markers with morphological features is extremely necessary to improve the effectiveness of treatment and increase the survival rates of patients with this pathology.

The study objective is to assess the prevalence of expression of HER2/neu, PD-L1, and RET mRNA in salivary gland malignancies and assess their impact on overall and disease-free survival.

Materials and methods. Fifty-nine patients with a confirmed diagnosis of salivary gland cancer (stages II–IVA) were examined in the period from 2012 to 2014 at Saint Petersburg City Clinical Oncology Dispensary. All materials were subjected to immunohistochemical research to determine the expression of HER2, PD-L1 in tumor and immune cells, the CPS index was calculated, and the frequency of the mRNA gene RET expression using a real-time polymerase chain reaction was detected.

Results. The overall survival of patients with mild and high HER2 expression was 41 months (95 % confidence interval (CI) 4.50–72.00), which is more than 4 time less than in patients with low or no expression (p = 0.00715). Significant differences were also received in the progression-free survival in the group of patients with negative or insignificant expression of HER2 receptors. The overall survival of patients with CPS >1 was 72 months (95 % CI 19.5–72.00) and significantly differed from the group of patients with CPS <1, where it was not yet achieved (p = 0.0124). mRNA expression of the RET gene was detected in 13 out of 48 cases, which was 27.08 %. The expression level ranged from 0 to 0.205. The progression-free survival in the group of patients with mRNA expression was 168 months (95 % CI 16.00–168.00) and tended to increase in the group of patients who did not have this expression.

Conclusion. When analyzing the obtained data, it was proved that knowledge of the salivary glands malignant tumors receptor status become one of the factors in determining the prognosis of the disease, as well as a predictive factor of targeted drugs effectiveness (after сonducting prospective randomized studies).
MODERN APPROACHES TO THE STATE AND DEVELOPMENT OF HISTORICAL HERMENEUTICS: PEDAGOGICAL ASPECT
Authors: Vanovska I.
Published: November 2020

The article is devoted to the definition of the features of historical hermeneutics, the development of the concept of "understanding" within the pedagogical hermeneutic method; the inseparable connection of the theory of understanding and hermeneutics is shown; the path of the formation of hermeneutics as a direction of history has been followed and the vision of understanding by different researchers is considered. The question of the expediency of expanding the traditional means and methods of historical science at the expense of hermeneutics was violated. Such hermeneutical arsenal was used as attention to the historical text, the disclosure of its meaning (explicit and implicit), the use of practical hermeneutic knowledge in the process of studying the evolution of historical hermeneutics, pedagogical conditions and technologies that provide this understanding are considered. The role of pedagogical culture of teachers as the main factor of understanding is given. The relationship between education, personality and socio-cultural environment and its influence on the processes of understanding are considered. The survey makes it possible to conclude that the process of understanding is a complex methodological problem that is studied from different sides by hermeneutics, pedagogy, semiotics, history, psychology, sociology, and a number of other sciences. At the same time, the task is not to contrast all of these methods and approaches, but to reasonably combine and supplement them in order to obtain as the most accurate, complete and comprehensive understanding of the various aspects of the problem of understanding. The profound transformations that have taken place in modern society have put science and history in particular, in the face of the obvious fact of rethinking a large number of issues raised by the current needs of a new state of socio-economic and socio-cultural relations.
THE RELEVANCE OF FORMING THE IMAGE OF THE ARMED FORCES OF UKRAINE
Authors: Motyka S.
Published: November 2020

The image of the Armed Forces of Ukraine is a complex and multifaceted socio-psychological and political phenomenon. A professionallycreated image functions as the most adequate informational object, creating public affection and recognition assuring the adequate perception of the Armed Forces as the power institution of the state. Thus, there's a relevant national challenge to form the positive image of the Armed Forces of Ukraine, and the numerous and versatile definitions of the term "image", the existence of a great number of approaches aimed at interpreting this definition, prove the multilateral aspects, the multidimensional categories and the significant scientific interest to this particular challenge.The Armed Forces of Ukraine is one of the most important elements of the political system of both state and society. In accordance with the Law of Ukraine "On the Armed Forces of Ukraine", the purpose of their existence is the protection of national interests, territorial integrity and inviolability of state borders. Considering the current state of development of the Ukrainian society, the state and its Armed Forces which is determined by the permanent increase of importance of the spiritual component, the issues of patriotic education and forming the image of the Armed Forces, are becoming the top state priority.The realities of modern life determine the objective necessity to develop a clear concept and the generic PR-strategy of the informativecommunication policy of the Armed Forces at a national level, with the aim to establish their positive image, based on the scientific approach and prominent world experience, yet taking into account the modern Ukrainian realities.The international experience has a variety of examples when the implementation of image technologies happens to play a significant role in solving a number of internal state developing tasks, namely: harmonizing the military-civil relations; increasing the level of the military-patriotic education and the general awareness of society in terms of task and activity of the Armed Forces, establishing firmness and sustainability of the moral-psychological state of the subordinated personnel, reinforcing military discipline etc.The information on the Armed Forces of Ukraine is to reflect the actual state of affairs. It is the irrelavance and the disproportion of theinformational material about the Armed Forces of Ukraine and the realities of life that has promoted the lack of trust in the course of the years of Independence, not only to the military command in particular, but to the state authorities as a whole.The article presents an analysis of the relevance of forming the image of the Armed Forces of Ukraine.
THEORETICAL ESSENCE AND PRACTICE OF IMPLEMENTATION OF THE SYSTEM
APPROACH IN FORMATION OF PROFESSIONAL RELIABILITY OF FUTURE OFFICERS IN
THE ARMED FORCES OF UKRAINE
Authors: Ryzhykov V. , Horiacheva K.
Published: November 2020

The methodology of systematic approach of guaranteeing the quality of training for military specialists in higher military educational institutions is disclosed in the article. It was determined that the process of education and upbringing takes place under conditions of change of pedagogical goals in any pedagogical system. This process is accompanied by the emergence of new tasks in the field of education and education as society develops. There is a constant updating of scientific information, in the conditions of improvement of existing ones and creation of new methods of teaching and upbringing. There is a constant update of the student and teacher contingent throughout the learning and upbringing process. The systematic approach as a methodological basis for the development of quality assurance systems for the training of military specialists in higher military educational institutions is revealed. It is found that the systematic approach does not exist in the form of a clear methodology with a defined logical concept. This system, formed from a set of logical techniques, methodological rules and principles of theoretical research, thus performs a heuristic function in the general system of scientific knowledge. The functioning of the system is the process of professional training of future military specialists in higher military educational establishments. An important result of the functioning of the system is the high level of readiness of future military specialists for practical activity. This can be achieved by ordering the system based on certain principles. These principles include: the principle of objectivity, completeness, specific-historical (genetic) approach, systematic, contradictory pedagogical experience.
THE PROACTIVE ENGAGEMENT OF YOUTH AS AN IMPORTANT FIELD IN TERMS OF ESTABLISHING A POSITIVE IMAGE OF THE ARMED FORCES OF UKRAINE
Authors: Sokolina O.
Published: November 2020

The article provides an analysis for the engagement of youth as an important field in terms of establishing the positive image of the Armed Forces of Ukraine. The social-psychological peculiarities of youth have been determined. It has been pointed out that in the process of establishing a positive image of the Armed Forces of Ukraine it is of crucial importance to fall back on the up-to-date needs and values of the youth.It has been stated, that currently the mass-media in Ukraine as well as civil and volunteer organizations are conducting activities on establishing the positive image of the Armed Forces of Ukraine. The example of the Military institute at the Kyiv National Taras Shevchenko University demonstrates the activities performed by a civil organization aimed at engaging and involving the youth, the prior tasks of which are the following: the establishment of a system of interaction with youth (civil) military organizations, the provision of practical knowledge, abilities and skills to cadets in accordance with the abovementioned spheres of activity, the training of cadets to be able to provide first medical aid under extreme conditions, the training of cadets to be able to act mutually as a part of a stainable group under extreme conditions intensifying the patriotic education.The main results of the educative efforts is to be the readiness of a young individual to perform military-patriotic activity as an internally integral phenomenon, which includes the five main elements − the educational, physical, psychological, social and spiritual that is demonstrate d by a positive attitude towards the military service in the Armed Forces of Ukraine.It has been pointed out that the establishment and the development of the system of national-patriotic education will facilitate the fortification of principles of love and honor to the Motherland, its history, language, culture, science sports, national and universal human values.
THE PECULIARITIES OF MAPS IN NATO
Authors: Goncharenko O. , Kukol V. , Mikheli S.
Published: November 2020

The article describes basic data about the features of creating and operating of NATO maps. The article provides informationabout scale standards for NATO topographic maps. The structure of topographic maps, the order of their creation, mainpurposes, tasks, requirements according to NATO standards are considered. Topographic maps at scales of 1:25 000, 1:50 000and 1: 100 000 are created by NATO countries in accordance with national requirements while maintaining their traditionaltransition to the creation of topographic maps, but adhering to a single NATO standard for mandatory mapping of WGS -84 andUTM grids, the printing of explanation symbols and abbreviations in English and application of geographical names in Latin. Atpresent, there is a coherent NATO geopolitics for the creation of topographic special maps (including digital maps), the basicprinciple of which is that each NATO member is responsible for providing the necessary cartographic materials to its troops andNATO forces on its territory and to the globe. for planning and conducting military operations. A 1: 250,000 scale map is used tostudy and evaluate in detail individual, relatively small but important areas, when crossing water obstacles, during hostilities inlarge settlements, as well as when designing and constructing large engineering structures. Projections of topographic maps ofscale 1: 250 000 are considered, specifics of delineation and designations adopted for the map, features of the content of th etopographic map according to NATO standards. The maps are created in the Universal Transversal Mercator Projection (UTM),the Universal Polar Stereographic Projection (UPS) and the Lambert Conformal Conic Projection. The article presents a system ofgraphic symbols and symbols of NATO.
MAP SEMIOTICS AND THE CONCEPT OF «FIELD» IN THE ATLAS OF UNIVERSITY (Atlas of HEIs) EDUCATIONAL – MANAGERIAL TYPE
Authors: Molochko N.
Published: November 2020

Map semìotiсs formed at the junction of cartography and semiotics, linguistic science, which investigates the properties ofcharacters and iconic systems as language structures. The importance of the consideration of its provisions for the newmethods and different way of spatial analysis applications and in the used to modern techniques and methods of spatial analysisand determination of the features of the state and development of material objects, processes and phenomena and their changesin time, is conditioned by the widespread use in different areas of public activity of the object language of cartography, therequirements for which are constantly increasing. In particular, this applies to the field of science, where the concept of "field"defines the transition from "discrete to continual" in which the map semiotics provisions of cartographic modeling are essential.Examples of maps of the "fields" of density of the manifestation (spreading) of natural, social and man-made phenomenadeveloped in different directions of scientific and practical implementation, consider the essence of the application of thenormalized structure of the semiotic sides of maps content, as a reference of requirements, to justify the methodology of suchresearch, including for institutions of the Higher Education System of Ukraine (HEIs).The work explores the possibility of using the concept of "field" in atlas mapping modeling. On the basis of this concept, thedensity (thickness) of the placement (spatial organization) of the structural units Taras Shevchenko National University of Kievwithin the borders of Kiev is justified. Its mapping, in the form of developments of the interactive atlas of the university, locallevel, educational - managerial type, because of the dispersed territorial structure and thematic content of its main sections iscarried out for the first time.