bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of the number of components in the PARAFAC model with a nonnegative tensor structure: A simulated EEG data study
Authors: Rošťáková Zuzana , Rosipal Roman
Published: November 2021

Parallel factor analysis (PARAFAC) is a powerful tool for detecting latent components in human electroencephalogram (EEG) in the time-space-frequency domain. As an essential parameter, the number of latent components should be set in advance. However, any component number selection method already proposed in the literature became a rule of thumb. Existing studies have demonstrated the methods’ performance on artificial data with a simplified structure, often not mimicking a real data character. On the other hand, the ground-truth latent structure is not always known for real-world data. With the objective to provide a comprehensive overview of component number selection methods and discuss their applicability to EEG, our study focuses on nontrivial and nonnegative simulated data structures resembling real EEG properties as closely as possible. This is achieved through an accurate head model and well-controlled cortical activation sources. By considering different noise levels and disruptions from the optimal structure, the performance of the twelve component number selection methods is closely inspected. Moreover, we validate a new approach for component number selection, which we recently proposed and applied to EEG tasks. We found that methods based on the eigenvalue analysis, variance explained, or presence of redundant components are inappropriate for component number selection in EEG tensor decomposition. On the other hand, three existing methods and the newly proposed approach produced promising results on nontrivial simulated EEG data. Nevertheless, component number selection for PARAFAC analysis of EEG is a complex yet unresolved problem, and new approaches are needed.
Peer‐reviewing geen valide basis voor erkennen en waarderen van onderzoeksprestaties
Authors: Breetvelt Iris
Published: November 2021

Peer-reviewing fungeert als poortwachter voor onderzoeksvoorstellen en wetenschappelijke publicaties. In het statement van de VSNU over Erkennen en Waarderen van wetenschappers (Recognition and Rewards) wordt niet kritisch gereflecteerd op peer-reviewing ter beoordeling van wetenschappelijke prestaties. De kwaliteit van referentenrapporten als beoordeling van onderzoeksvoorstellen is soms twijfelachtig. De referentencommentaren op manuscripten voor publicatie zijn vaak inadequaat, inconsistent en/of vooringenomen. De beoordelingen door vakgenoten missen betrouwbaarheid en validiteit. In het beoordelingsproces zijn auteur(s) en reviewers ongelijkwaardig. Peer-reviewing draagt daardoor bij aan aangeleerde hulpeloosheid en sociale onveiligheid van wetenschappers. Peer reviewing ter beoordeling van onderzoeksprestaties verdient heroverweging.
Origins of vocal-entangled gesture
Authors: Pouw Wim , Fuchs Susanne
Published: November 2021

Humans move their upper limbs for communicative purposes during speaking. They gesture. Such movements interact on multiple levels with speaking. In connection to what is said, gestures meaningfully shape with varying means of representation. Yet, gestures also have non-representational aspects; they quasi-rhythmically pulse with prosodic structure in speech. In explaining how modern human gesturing practices emerge in phylogeny or ontogeny, it is undisputed that gestures proliferated because they provide particularly effective means to refer to absent or distal state of affairs. It suggested that displaced or deictic reference is gestures' most basic proper function. The upshot is that the non-representational pulsing quality of gesture is completely ignored as something a) that requires an explanation or b) something that can elucidate how gesture practices emerged from more basic beginnings shared with other animals. However, recent research provides evidence for direct biomechanical interaction between pulsing manual movements and respiratory-vocal activity. We argue that this physical link is enacted during infant vocal-motor babbling - way before infants learn to represent manually. Further, we argue that gesture-vocal biomechanics directly relates to the cross-species phenomenon of locomotor-respiratory(-vocal) coupling. Given that gesture-speech biomechanics has its roots in locomotor-respiratory coupling, it can be related to bipedalism and respiratory complexification, i.e., an adaptation for the faculty of speech. We conclude that the physical origins of vocal-entangled gesture run much deeper and unfolded more gradually than currently assumed. The entanglement of sound and movement arose out of natural physical coalitions between vocal, respiratory, and limb systems that are forced to interact. We thus invert current argumentation of how gesture and vocalization must have evolved and rethink what is foundational of human gesture. This perspective underlines that a more comprehensive investigation of the physical basis of bodily communication can yield new sources of semiotic significance in human and non-human animals.
Interpersonal, Affective and Compulsive Features of Driven Exercise in Anorexia Nervosa
Authors: Kolar David R. , Kaurin Aleksandra , Meule Adrian , Schlegl Sandra , Dittmer Nina , Voderholzer Ulrich
Published: November 2021

Background: This preregistered (https://osf.io/g9ajb) study sought to integrate the current literature on trait compulsivity into maintenance models of driven exercise in anorexia nervosa (AN). We tested whether compulsivity increases the likelihood of driven exercise via interpersonal and affect-regulatory pathways. Methods: We used multilevel structural equation modeling to test the hypothesis that trait compulsivity predicts a stronger within-person link between affect-regulatory difficulties or interpersonal sensitivity and driven exercise in female adolescents and adults with AN. We used data from five assessments across inpatient treatment and 6-months follow-up of 207 adult and adolescent patients with AN (1036 datapoints).Results: In line with our hypotheses, patients who generally experienced more affect-regulatory difficulties or stronger interpersonal sensitivity tended to engage in more driven exercise. Moreover, high levels of trait compulsivity amplified the effect of interpersonal sensitivity on driven exercise across time. Contrary to our hypotheses, the link between affect regulation and driven exercise was not moderated by compulsivity. Similar effects on general ED psychopathology were found, but no cross-level moderation of compulsivity.Limitations: Due to sample size, potential age- and subtype-dependent effects were not analyzed. Conclusion: Our results suggest that driven exercise coincides with self-reported experiences of interpersonal sensitivity and that this link varies as a function of compulsivity such that the within-person coupling is stronger among those scoring high on compulsivity. To derive clinically useful functional models of driven exercise, future studies might use intensive longitudinal data to investigate its momentary associations with affect and interpersonal sensitivity in the context of compulsive traits.
Imagination and the Prosocial Personality: Mapping the Effect of Episodic Simulation on Helping Across Prosocial Traits
Authors: Campbell Dylan , Tusche Anita , O'Connor Brendan Bo
Published: November 2021

Prior work suggests that imagining helping others increases prosocial intentions and behavior towards those individuals. But is this true for everyone, or only for those who tend towards – or away from – helping more generally? The current study (N=283) used an imagined helping paradigm and a battery of behavioral and self-report measures of trait prosociality to determine whether the prosocial benefits of imagination depend upon an individual’s general tendency to help others. Replicating prior work, we found links between imagination and prosociality and support for a three-factor model of prosociality comprising altruistically, norm-motivated, and self-reported prosocial behaviors. Centrally, the effects of imagination on prosociality were slightly larger for less altruistic individuals but independent of norm-motivated and self-reported prosociality. These results suggest leveraging people’s abilities for episodic simulation as a promising strategy for increasing prosociality in general, and perhaps particularly for those least likely to help otherwise.
Catjects – under reconstruction
Authors: Baecker Dirk
Published: November 2021

Catjects are neither objects nor subjects, yet draw on both. Just as subjects catjects underlie themselves and just as objects they face themselves. They are categorical constructions of realities out of reality. Catjects describe a calculus of distinctions combining observations within their contexts to produce and reproduce phenomena of all kinds, most notably social one. Social phenomena are phenomena which entertain relations of communication (and control) between observations and their distinctions and which rely on communication (and control) as their mechanism to differentiate within an environment and to reproduce in time. The paper draws on George Spencer-Brown's calculus of indications to understand distinctions as connections. Catjects may best be understood as eigen-values of recursive and reflexive functions. Catjects are ways to model, formalize, or symbolize control projects within natural, social, and artificial domains. Among other things they help to understand digitization as a way of systems to code how they draw on their environments and produce their information. – under reconstruction, see https://www.researchgate.net/project/Catjects-Project
Kupiec wenecki
Authors: Shakespeare William
Published: November 2021

The play written by William Shakespeare, in a new translation by Piotr Kamiński. Critical edition with commentary.
Body image self-consciousness, sexting, and sexual satisfaction among midlife Canadians
Authors: Falconer Tasha , Quinn-Nilas Christopher , Milhausen Robin
Published: November 2021

Life circumstances at midlife are often different than those for younger adults (e.g., relationship type and duration, physical health, experience of sexual problems), and these circumstances impact experiences of sexuality and sexual behaviour. Past research on sexual behaviours like sexting, which has been primarily conducted on young people, may not generalize to middle-aged adults. Sexting may be a beneficial activity for midlife adults in long-term relationships who are seeking private and convenient ways to communicate sexual interest. Furthermore, as in younger samples, sexting may be associated with body image and sexual satisfaction. A cross-sectional study with a sample of 640 midlife (40–59 years old) married Canadians was conducted to address these suppositions. Structural equation modelling was used to test the factorial validity of a body image self-consciousness (BISC) scale and to investigate the connections between BISC, sexting frequency (to communicate sexual interest, to initiate sexual activity, and that include a picture), and sexual satisfaction. Almost one-half of participants (43%) reported sexting to communicate sexual interest, 37% sexted to initiate sexual activity, and 18% sexted sexy pictures of themselves. Women with lower levels of BISC were more likely to sext (communicate, initiate, and pictures), and men with lower levels of BISC were more likely to send sexts with pictures. Both men and women with lower levels of BISC and those who engaged in sexting to communicate sexual interest had higher levels of sexual satisfaction. Sexting may be an opportunity for busy marital partners to engage in technology-mediated sexual activity when apart. The current results indicate that technology-mediated sexual communication has similar psychological mechanisms to face-to-face interactions and that sexting may be a beneficial behaviour for sexual satisfaction within midlife marriages.
On the breach: Identifying infringements of section 35 rights
Authors: Wilkins Kerry
Published: November 2021

Section 35 of the Constitution Act, 1982, the Supreme Court of Canada has said, protects existing Aboriginal and treaty rights from unjustified infringement at the hands of federal and provincial legislatures and governments. To give meaningful effect to section 35’s protection, we need, therefore, to understand what counts as infringement of such rights and why. The Supreme Court’s own jurisprudence to date on this question, alas, disappoints; it does not withstand close critical scrutiny. This article calls attention to several shortcomings and inconsistencies in that jurisprudence and proposes for initial consideration a more inclusive approach to infringement identification, one that draws a sharper distinction between the infringement and justification inquiries. Adoption of such an approach, however, could have unwelcome substitution effects, prompting cautious courts to be more selective when asked to authenticate future claims of Aboriginal right, more penurious when construing the constitutionally protected scope of particular treaty or Aboriginal rights and/or more generous to governments during the justification inquiry. If the goal is to optimize the protection that Canadian constitutional law affords to treaty and Aboriginal rights, we shall need to be mindful of the interdependence among the authentication, infringement, and justification inquiries, and we shall need to understand much more clearly than we currently do just where the outer limits are beyond which mainstream Canadian law cannot, or will not, countenance Indigenous ways and why.
Analysis of Difference of Double Lung Ultrasound in Patients with Single Lung Ventilation
Authors: Zheng Xin , Su Yang , Yang Haitao , Zheng Xin
Published: November 2021

Objective: To retrospectively analyse the lung ultrasound images of 60 patients undergoing thoracoscopic partial pneumonectomy and compare the difference of bilateral lung ultrasound images.
Results: B3 lines were predominant in ventilating side lung, B7 lines and atelectasis were predominant in operative side lung.
Conclusion: Short-term lung injury after one-lung ventilation is mainly on the ventilation side, and the main manifestation is pulmonary edema.
Position of the Russian Orthodox Church on the Problems of Juvenile Justice
Authors: Зотин Андрей Александрович
Published: November 2021

Последние два десятилетия ознаменовались попытками введения западных стандартов ювенальной юстиции в российское законодательство, которые вызывают опасения в обществе. Русская Православная Церковь не осталась в стороне и выразила своё мнение по этому вопросу.

The last two decades have been marked by attempts to introduce Western standards of juvenile justice in Russian legislation, which raise concerns in society. The Russian Orthodox Church did not stand aside and expressed her opinion on this issue.
Legal Protection of “Religious Feelings of Believers” in Russian Federation
Authors: Семенова Наталия Сергеевна
Published: November 2021

Введение уголовной и административной ответственности за оскорбление религиозных чувств верующих в Российской Федерации вызвало неоднозначную оценку. В статье рассматривается необходимость введения указанной ответственности, понятие оскорбления религиозных чувств верующих, позиция Русской Православной Церкви, юридического сообщества, а также общества в целом. Статья подготовлена при финансовой поддержке РФФИ в рамках научного проекта №18-011-00292.

The introduction of criminal and administrative liability for insulting the religious feelings of believers in the Russian Federation caused an ambiguous assessment. The article considers the necessity of introducing this responsibility, the concept of insulting religious feelings of believers, the position of the Russian Orthodox Church, the legal community, and society. The article was prepared with the financial support of the Russian Foundation for Basic Research in the framework of the research project No. 18-011-00292.
Comparative Analysis of the Germany and France Approaches to Relations with Russia
Authors: Timofeev Pavel
Published: November 2021

The article presents a comparative analysis of Germany and France’s approaches towards Russia. The authors compared the place of Russia in the official narrative and program documents of Germany and France as well as their positions on the useful practical mechanisms for developing a dialogue with Russia, on main political (Ukraine crisis) and political-economic issues (Nord Stream-2, negotiations on the Sputnik vaccine) in Russia-EU relations. The authors conclude that conceptual solidarity and agreement on political issues do not prevent Germany and France from disagreeing on some economically sensitive issues of relationships with Russia.
Socio-cultural Relations and Communications in the Post-Pandemic World: Global Reversal or Situational Crisis of Postmodernism
Authors: Yevstafiev Dmitriy
Published: November 2021

The world of late globalization is distinguished by duality and internal contradictions in socio-cultural relations and communications, which reflects in the crisis of universal models of social behavior. The only area where the principles of social universality remain relevant is the sphere of communications, where active development of new formats and the emergence of new cultural proto-artifacts continues. The coronavirus pandemic has altered the logic of development in this segment of global interaction, since it affected the very foundations of universal social behavior models. Socio-cultural relations, due to a complex of reasons, are becoming a sphere where tendencies interact and compete as well as institutions associated with the period of late globalization, including those that emerged on the wave of its crisis. At the same time, the communication environment becomes extremely important, since new technologies will make it possible to reflect not only macro-trends, but also the evolution of micro-cultures, which, in the context of a systemic (institutional) crisis of globalization, are becoming more important than usual. This symbiotic socio-cultural-communication phenomenon can become one of the most important factors in determining future models of global development. The article analyzes the most important directions of development of the sphere of socio-cultural communications and their transformation in 2020-2021. The article amplifies whether the trends for socio-cultural developments that formed through the pandemic crisis lead towards the formation of a new model of socio-cultural development or such trends remain within the traditional framework. The major conclusion is that the formation of the model has not started yet though the risk of distraction of global socio-cultural – and probably social universality – became obvious. Conclusions are made regarding further transformation of the sphere of socio-cultural development in the current information environment.
Оперна вокальна інтерпретація як предмет наукового дискурсу
Authors: Борко Ігор
Published: November 2021

Художньо-виражальні засоби творення сценічної образності в оперному мистецтві тісно пов’язані зі стилістикою оперного співу виконавця, невід’ємною складовою якого є вокальна інтерпретація. Мета дослідження – проаналізувати сучасний стан наукових досліджень вокальної інтерпретації як невід’ємної складової оперного мистецтва. Методологія дослідження спирається як на загальнонаукові, так і на спеціальні методи дослідження: аналіз – для з’ясування змісту досліджень з проблем оперної вокально-сценічної інтерпретації; історико-генетичний – для розуміння значення вокальної інтерпретації в історії розвитку оперного мистецтва; дедуктивний – спрямував дослідження від узагальненого розуміння теорії оперного жанру до конкретного, зокрема ролі вокальної інтерпретації як складової оперно-виконавського мистецтва; компаративний – для порівняння характеристик вокальної інтерпретаційної стилістики виконавців. Наукова новизна. Ця робота є спробою осягнути науково-аналітичний досвід у царині сценічної оперно-вокальної інтерпретації. Висновки. Вокально-сценічна, образно-творча діяльність оперного співака як виконавця-інтерпретатора вимагає глибокого аналізу та розуміння виконуваного музичного твору в культурно-історичному контексті епохи поруч із високою майстерністю та яскравістю самовираження під час розв’язання комплексу художньо- виконавських і технічних завдань. Зважаючи на це, оперний виконавець створює власну інтерпретаційну версію вокального твору, яка має бути різноманітною, але визначеною межами традицій. Інтерпретаційні версії визначаються особливостями донесення змісту художнього тексту, емоційного підтексту оперної партії за допомогою різних комплексів експресивних засобів, прийомів вокальної техніки та ступенем занурення в історичний контекст. Чіткість артикуляції та дикція в сукупності з іншими засобами художньої виразності та індивідуальними особливостями звуковидобування визначають оригінальний стиль оперного співака-інтерпретатора. Використання нових і традиційних вокально-інтерпретаційних моделей відкриває широкі можливості для дослідження історико-теоретичного аспекту оперного мистецтва різних періодів, його композиторських шкіл та жанрів. Аналіз наукових досліджень показав, що у них питання оперної вокально-сценічної інтерпретації висвітлювались або дотично, у контексті вивчення інших проблем оперного мистецтва, або на відповідному етапі його історичного розвитку. Наразі перед сучасною науковою думкою постає завдання комплексного осмислення ролі вокальної інтерпретації в процесі створення сценічної образності в оперному мистецтві з визначенням різних вокально-інтерпретаційних
Про характеристику алмазів з давніх осадових товщ крайових частин платформ
Authors: Zinchuk M. M.
Published: November 2021

На підставі проведених комплексних досліджень підтверджено припущення щодо різних особливостей алмазів з кількох перспективних ділянок Тунгуської алмазоносної субпровінції, серед яких найперспективнішими є деякі території Байкітської та Південнотунгуської областей. Істотний вплив на формування тут давніх розсипів алмазів має докембрійська фаза кімберлітового магматизму в Присаянні та інших подібних структурах Сибірської платформи, звідки кристали зносилися в Іркутський амфітеатр. Обґрунтовано гіпотезу про при­урочення областей поширення округлих алмазів до полів розвитку докембрійських теригенних формацій. Це дає змогу прогнозувати виявлення високопродуктивних тіл і в крайових частинах давніх платформ, що вже засвідчено на прикладі Східноєвропейської платформи. Результати вивчення алмазів уможливлюють термальний вплив на кристали в умовах давніх вторинних колекторів магматичних утворень трапової формації, що спричинило перехід зелених плям пігментації в бурі. Судячи з наявності баласів у розсипах басейну р. Нижня Тунгуска, карбонадо в басейні верхньої течії р. Вілюй і баласів тунгуського типу в Середньомархінському алмазоносному районі (СМАР), типових округлих алмазів і тригонтриоктаедрів I різновиду, знесення таких алмазів могло сягнути зони зчленування Тунгуської синеклізи й Анабарської антеклізи (межиріччя Марха — Тюнг). За низкою типоморфних особливостей вивчені алмази близькі до кристалів розсипів Уралу й Середнього Тіману, але на відміну від них, характеризуються вищим (не менш як у 3–5 разів) умістом ламінарних кристалів ряду октаедр-ромбододекаедр, що свідчить про полігенезу їхніх корінних джерел (не менш як двох полів докембрійської фази й одного — мезозойської фази магматизму). Типоморфні особливості алмазів важливі для палеографічних реконструкцій поширення давніх продуктивних відкладів. Проведене мінералогічне районування території розсипної алмазоносності за типоморфними особливостями алмазів відкриває можливості локалізації перспективних площ і пошуку корінних джерел цього мінералу, що є набагато стійкішим в екзогенних умовах, порівнюючи з іншими мантійними утвореннями. Отримані типоморфні особливості алмазів описуваних осадових товщ можна також використати для відновлення екзогенної історії на шляху від їхніх джерел до місць сучасного розміщення в розсипах, що дуже важливо для визначення джерел знесення алмазоносного матеріалу.
Alltägliche Bewältigungspraxen obdachloser Menschen
Authors: Sellner Nora
Published: November 2021

Obdachlosigkeit tritt nicht nur gesellschaftlich, sondern auch in der Forschung als Randthema in Erscheinung. Dieses Buch rückt die Bewältigungspraxis obdachloser Frauen und Männer in den Fokus, indem ein exploratives und rekonstruktives Vorgehen realisiert wird, welches die Eigenlogik ihrer Alltagspraxis thematisiert. Ziel des Buches ist eine mehrperspektivische Betrachtung und Diskussion zur Bedeutung der Erkenntnisse über die Bewältigungspraxen obdachloser Frauen und Männer.
Ökonomische Bildung zwischen fachwissenschaftlicher Abstraktion und lebensweltlicher Konkretion
Authors: Günther Anja
Published: November 2021

Welche Vorstellungen haben Schüler*innen von Ökonomie? Wie schätzen sie den gegenwärtigen Ökonomieunterricht ein, welche Wünsche und Ängste begleiten sie? In der vorliegenden Studie steht der Wirtschaftsunterricht der Sekundarstufe II in Sachsen im Fokus. In Form von Interviews wird die Perspektive der Schüler*innen mit Blick auf das System Wirtschaft erkundet, um ihre Lebenswirklichkeit und ihre Anforderungen in die Konzeption eines Curriculums zur ökonomischen Bildung einfließen zu lassen. Im Ergebnis werden didaktische Implikationen abgeleitet, deren ökonomiedidaktische Spezifikationen in ein allgemeindidaktisches Rahmenmodell implementiert werden.
The relationship of sensorimotor and function with activities of daily living and disease specific parametres in patients with rheumatoid arthritis
Authors: KESKİN KAVAK Songül , SEZER Nebahat , AKTEKİN Lale
Published: November 2021

Objective: To evaluate the level of effect on the sensorimotor functions of the hand in patients with rheumatoid arthritis (RA) and investigate the relationship between this level and patients’ daily life activities and disease-specific parameters.

Material and Method: This case-control study involved the evaluation of 80 patients with RA and 50 healthy volunteers aged 20-65 years. The coarse and fine grip strength of the patients was evaluated with hand dynamometer and pinch meter. The sensory evaluation of the hand was undertaken using the Semmes-Weinstein monofilament test (SWMT). The hand skill level was evaluated with Duru Oz Hand Index (DHI). The daily living activities of the patients were investigated using the Health Assessment Questionnaire (HAQ). The Disease Activity Score 28 (DAS28) was used to evaluate disease activity.

Results: The mean DAS28 score of the RA group was at a mild level (DAS 28
First-line palliative chemotherapy clinical benefit is a key determinant of survival in metastatic uterine leiomyosarcoma
Authors: ERASLAN Emrah , İLHAN Ayşegül , YILDIZ Fatih , DOĞAN Mutlu
Published: November 2021

Aim: To evaluate whether obtaining a clinical benefit with first-line therapy in patients receiving palliative systemic therapy with a diagnosis of metastatic uterine leiomyosarcoma (ULMS) provides a survival benefit and the factors that may predict first-line therapy response.

Material and Method: This study was a retrospective observational single-center analysis conducted with patients diagnosed with metastatic ULMS. Patients who received palliative chemotherapy with an ECOG PS of 0 or 1 at the time of diagnosis of metastatic disease were included in the study. Main patient characteristics, first-line palliative treatment responses, progression-free survival, and overall survival (OS) were reviewed retrospectively. Multivariate analyses were performed to determine the independent predictive factors of first-line palliative treatment response and overall survival.

Results: Of the 36 patients whose medical records were evaluated retrospectively, 24 patients who were eligible for the study were included in the study. Gemcitabine plus docetaxel combination chemotherapy was the most commonly used treatment protocol (n=12, 50%) for first-line palliative treatment. While a complete response as a first-line treatment response could not be achieved, clinical benefit (partial remission and stable disease) and progressive disease were observed in 15 (62%) and 9 (37.5%) patients, respectively. Binary logistic regression analysis failed to detect any independent predictive factors for the clinical benefit of first-line palliative therapy. Median (OS) was 19.7 (95% CI, 4.1-35.3) months for all patients (N=24). Median OS was 25.6 (95% CI, 21.0-30.2) months and 6.9 (95% CI, 1.7-12.2) months for patients with and without the clinical benefit of first-line palliative chemotherapy (p=0.004). Cox-regression analysis revealed that increasing age at diagnosis of metastatic disease (HR=0.929, 95% CI 0.870-0.992, p=0.027), pulmonary metastasectomy (HR=0.162, 95%CI 0.031-0.863, p=0.033), and presence of first-line palliative chemotherapy clinical benefit (HR=0.195, 95% CI 0.063-0.606, p=0.005) were independent predictive factors for a better OS.

Conclusion: In metastatic ULMS, for which the survival benefit is not clear with palliative chemotherapy, prolonged survival can be obtained in patients with clinical benefit with first-line palliative chemotherapy. There is a need for new studies to determine the factors that will predict the clinical benefit of first-line palliative chemotherapy.
Evaluation nutritional status and anthropometric parameters in patients with chronic hepatitis B
Authors: YILMAZ ÖNAL Hülya
Published: November 2021

Introduction: Hepatitis B continues to be a major health problem around the world. 257 million people are estimated to be chronically infected with hepatitis B worldwide. Chronic hepatitis B (CHB) patients are likely to develop various comorbidities, including diabetes, insulin resistance, hyperlipidemia, nonalcoholic fatty liver disease, and obesity. Proper nutrition is essential for the management of both hepatitis B and its associated comorbidities.

Material and Method: The study was completed a total of 105 patients. The universe of the study comprised of CHB patients who were admitted to the nutrition and dietetics outpatient clinic of a public hospital in Turkey between 1 October 2019 and 31 December 2019. Biochemical and ultrasound results, anthropometric measures, demographic characteristics, dietary habits, and 1-day food records were retrospectively recorded from patient files.

Results: Female patients were more likely to consume 2 main meals per day (57.8%) whereas most male subjects (75.6%) consumed 3 meals. Both female and male patients had above-normal Body Mass Index (BMI) (31.2 kg/m2 and 29.2 kg/m2, respectively), and they also had high dietary fat (%) and cholesterol consumption than recommendation. In addition, males had borderline The fasting blood glucose (FBG), total cholesterol, and triglyceride levels, and both sexes were at risk for abdominal obesity. Dietary carbohydrate, fiber, B1, B6, calcium, magnesium, and phosphorus intake were higher in males than in females.

Conclusion: This study was found on above-normal BMI values, and high dietary fat (%), and cholesterol consumption in both males and females. Moreover, males had borderline FBG, total cholesterol, and triglyceride levels, and both sexes were at risk for abdominal obesity. In the setting of CHB, it is crucial to maintain an adequate and balanced diet to control body weight, prevent nutritional disorders, protect the liver, and improve overall well-being. More comprehensive studies are needed to better understand the link between nutrition and hepatitis B.
Is macrocytic erythrocyte a new prognostic parameter in critical COVID-19 disease?
Authors: SOYLU Veysel Garani , GÜLTEN Sedat , YILMAZ Ayşe , TAŞKIN Öztürk , DEMİR Ufuk , ÇATAN İNAN Funda
Published: November 2021

Introduction: In critical COVID- 19 patients, we aimed to examine the relationship mortality between the parameters and the macrocytic/microcytic erythrocyte population that are routinely evaluated in each patient admitted to the intensive care unit.

Material and Method: It is a retrospective cross-sectional study and was conducted in Kastamonu University, Faculty of Medicine, a tertiary hospital intensive care units located in the North of Turkey .198 nonanemic critical COVID-19 patients treated between November 2020 and February 2021 were evaluated. The patients were divided into two groups as survival and non survival. Apache II score, saps II score and routine blood examinations of the patients were evaluated.

Results: Among the groups; APACHE II score (p
Relationship between hope and fatigue levels in cancer patients
Authors: ÇELİK Melike , UĞUR Özlem , KARADAĞ Ezgi
Published: November 2021

Aim: The aim of the present study is; to determine the relationship between fatigue and hope levels in cancer patients.

Material and Method: The study was conducted as a descriptive study. Data were collected using Socio-Demographic Data Qestionnaire, Herth Hope Index, Brief Fatigue Inventory (BFI). The questionnaires were filled outthrough face-to-face interviews.

Results: 213 cancer patients with 50.23% 21-54 years of age were taken into the study. There was no significant relationship between fatigue status of patients and sociodemographic variables. However, a significant correlation was found between the score of hope and the time after diagnosis(KW =2.608; p=0.053). In our study, the difference between mean score of hope level and gender, age,marital status, educational status and employment was not statistically significant.

Conclusions: There was a significant negative correlation between fatigue and hope total scores of the patients. This shows us that the management of fatigue during the illness and treatment positively affects the hope and patients are struggling with their disease. it is suggested that the diagnosis of fatigue and hope levels of the patients from the diagnosis and the planning of the attempts to manage them can be suggested.
The effect of body mass index on osteoporosis and fracture risk in patients with type 2 diabetes mellitus
Authors: ÖTEN Erol , ÇAPRAZ Mustafa
Published: November 2021

Aim: Type 2 diabetes mellitus (DM), osteoporosis and obesity are increasingly common diseases due to the increase in the elderly population and the change in eating habits. However, the relationship between diabetes, obesity and osteoporosis has not been fully clarified in studies in the literature. In our study, it was investigated whether the combination of diabetes and obesity caused osteoporosis and increased fracture risk.

Material and Method: Our study was carried out with a total of 95 patients between the ages of 40 and 80, including 24 males and 71 females, who were tested due to the preliminary diagnosis of osteoporosis and diagnosed with type 2 DM in the physical medicine and rehabilitation outpatient clinic. The demographic characteristics, body mass index (BMI), bone mineral density (BMD) measurements, X-ray imaging, and fracture risk assessment scale (FRAX) calculations of patients were performed. Groups were compared in terms of BMD and FRAX according to the BMI classification.

Results: BMD and FRAX hip values were higher in the obese group according to the BMI classification compared to the pre-obese/normal group (p0.05).

Conclusion: As a result of our study, it was observed that type 2 DM and obesity were associated with increased fracture risk despite high BMD values.
The role of ECG as a mortality predictor in COVID-19 patients treated in the intensive care unit
Authors: AYDEMİR Semih , ŞAHAN Ekrem
Published: November 2021

Background: COVID-19 infection has reached serious morbidity and mortality rates all over the world for a short time. Many studies have investigated the relationship of COVID-19 disease with mortality and morbidity. In this study, we wanted to elucidate the relationship between rhythm character (sinus rhythm vs atrial fibrillation) and QTc and frontal plane QRS-T angle, which parameters are reflecting the depolarization-repolarization kinetics, and mortality, which were not emphasized enough in previous studies.

Material and Method: 259 patients admitted to the intensive care unit due to COVID-19 infection between 01.04.2020 and 01.12.2020 was included in the study. The demographic characteristics of the patients, clinical backgrounds, laboratory values ​​at the time of admission to the intensive care unit, and 12 derivation ECG records were obtained from the patient files. Rhythm, PR distance, QRS duration and morphology, QT interval, T wave morphology, presence of atrioventricular (AV) block, QRS axis, presence of ventricular premature contraction, frontal plane QRS-T (f(QRS-T)) angle degree were determined on 12 derivation ECG records. Patient groups were classified as "deceased patient" and "survivors" and the relationship of these parameters with survival was tried to be elucidated.

Results: the frequency of atrial fibrillation was significantly higher in the "deceased patient" group. For patients in sinus rhythm, there was no difference between the two groups in terms of PR distance and 1st degree AV block. Severe AV block was not observed in either group. There was no difference between the two groups in terms of QRS morphology, T wave inversion, and ventricular premature contractions. QRS duration, corrected QTc duration, and frotal plane QRS-T angle values ​​were found to be statistically significantly higher in in the "deceased patient" group.

Conclusion: Atrial fibrillation, prolonged QTc duration and increased frontal plane QRS-T angle can be considered as mortality predictors in COVID-19 infection whose mortality rate is high all over the world.
A reliable source of information on botulinum toxin injection used in the treatment of spasticity: YouTube
Authors: ARAS Berke , KUZU Ömer
Published: November 2021

Aim: The aim of the study is to assess the quality and reliability of YouTube videos on botulinum toxin injection for the treatment of spasticity.

Material and Method: In this cross-sectional study, a search of YouTube videos was made on 15 September 2020, using the keywords "botulinum toxin and spasticity", "botulinum toxin treatment for spasticity", “spasticity management with botulinum toxin" "treating spasticity with botox". Two experienced reviewers on botulinum toxin injection on spasticity reviewed the first 200 videos. The quality of the videos was evaluated according to the Global Quality Scale (GQS) and three groups were formed: high quality, intermediate quality and low quality. The DISCERN tool was used to evaluate the reliability of the videos.

Results: Of the 77 videos analyzed according to GQS, 36 (46.8%) were high quality, 31 (40.2%) were intermediate quality and 10 (13.0%) were low quality. Most of the videos (44.15%, n=34) uploaded by health professionals (physiatrist, orthopedist etc.) and the majority of the health professional groups had produced high quality videos (67.64%). When the parameters of the videos were compared according to quality levels, no significant differences were found in the number of view, comment, likes, dislikes, video length, days since upload (p>0.05). Significant differences were only found between the groups in respect of the DISCERN scores (p
Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy
Authors: YILMAZ Ebru , ARSLAN Memnune , AKYOL Şefika , ÖZCAN Alper , ZARARSIZ Gökmen , ABDULREZZAK Ümmühan , KONTAŞ Olgun , CANÖZ Özlem , ÜNAL Ekrem , KARAKÜKÇÜ Musa
Published: November 2021

Aim: Hodgkin lymphoma (HL) constitutes 40% of childhood lymphomas and approximately 6% of all childhood cancers. It is tried to achieve cure with combined treatment modalities consisting of chemotherapy, radiotherapy, monoclonal antibodies, and new treatment agents such as nivolumab. Radiotherapy-related infertility, secondary cancer, thyroid dysfunction, cardiovascular diseases, pulmonary fibrosis, and local skin reactions can be seen in the pediatric age group with a long life expectancy. In this article, pediatric patients diagnosed with Hodgkin lymphoma without the use of radiotherapy in the treatment were evaluated retrospectively and the survival results were reported as a single-center experience.

Material and Method: The patients with Hodgkin Lymphoma in the Pediatrics Hematology-Oncology Center at Erciyes University between January 2010 and December 2019 were included in the study and the data of the patients were evaluated retrospectively.

Results: In 68 pediatric patients with a mean age of 10.7 (±4.6) years, the male/female ratio was 1.3. The most detected finding at the time of diagnosis was cervical lymphadenopathy (83.8%). The most common mixed cellular subtype was identified (48.5%). Stage I-II disease was observed in 38.3% of the patients, and stage III-IV disease was observed in 61.7% of the patients. The median follow-up period of the patients was 61 (range, 8.3-161.6) months. Disease-free survival and overall survival were 85.3% and 94.1%, respectively. Treatment modalities to be used in this disease group, which has a high chance of cure after cytotoxic treatment, should be selected considering treatment-related long-term complications.

Conclusion: Acceptable good results obtained without radiotherapy are satisfactory and the chance of curative success will increase with the addition of new target agents to the treatment.
Is there a relationship between the liver SUVmax values in FDG-PET/CT imaging and non-alcoholic fatty liver disease score?
Authors: ALTUNTUZCU Şadiye , GUZEL Fatih , UYAR Ali , KAPLAN İhsan , GÜZEL Yunus , TAŞDEMİR Bekir , YALÇIN Kendal
Published: November 2021

Aim: Non-alcoholic fatty liver disease is one of the most common causes of liver disease worldwide with an estimated prevalence of 20%–30% in adult population. Following the widespread utilization of PET in the evaluation of malignant diseases, F-18 FDG have also been reported to be used in non-malignant processes. The aim of this study is to elucidate whether the FDG SUVmax values determined by PET/CT in different adipose tissue samples and the liver change according to NAFLD score. During our desktop research we did not find any published article therefore, it is the first study in this field.

Materials and Method: A total of 230 patients who applied to Dicle University Faculty of Medicine, Department of Nuclear Medicine between March and April 2020 and who have been conducted FDG PET/CT for diagnosis, staging, restaging and evaluation of response to treatment were included in the study. Patients were divided into three groups according to their NAFLD score as patients with fibrosis score 0.676 (severe fibrosis group) group-3.

Results: Liver SUVmax levels were found to be significantly higher in group-3 than group-1. No significant difference was observed between group-2 and group-3. SUVmax levels measured from supracalvicular region, posterior scapular region and mesentery region were not different from each other in all three groups. Glucose-corrected liver SUVglu levels were found to be significantly lower in group-1 than group-3 (p=0.001). In terms of liver SUVglu levels, group-1 and group-2 and group-2 and group-3 did not differ statistically from each other. Supracalvicular SUVglu, posterior scapular SUVglu and mesenteric SUVglu groups were not different from each other.

Conclusions: The most important result of this study could be elaborated with increased FDG uptake in NAFLD. Liver FDG uptake increases as the severity of NAFLD increases as demonstrated by the NAFLD score.
Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer’s Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated
Authors: Barthélemy Nicolas R. , Toth Balazs , Manser Paul T. , Sanabria-Bohórquez Sandra , Teng Edmond , Keeley Michael , Bateman Randall J. , Weimer Robby M. , Wildsmith Kristin R.
Published: November 2021

Background: Understanding patterns of association between CSF phosphorylated tau (p-tau) species and clinical disease severity will aid Alzheimer’s disease (AD) diagnosis and treatment. Objective: To evaluate changes in tau phosphorylation ratios to brain imaging (amyloid PET, [18F]GTP1 PET, and MRI) and cognition across clinical stages of AD in two different cohorts. Methods: A mass spectrometry (MS)-based method was used to evaluate the relationship between p-tau/tau phosphorylation ratios on 11 sites in CSF and AD pathology measured by tau PET ([18F]GTP1) and amyloid PET ([18F]florbetapir or [18F]florbetaben). Cohort A included cognitively normal amyloid negative (n = 6) and positive (n = 5) individuals, and amyloid positive prodromal (n = 13), mild (n = 12), and moderate AD patients (n = 10); and Cohort B included amyloid positive prodromal (n = 24) and mild (n = 40) AD patients. Results: In this cross-sectional analysis, we identified clusters of phosphosites with different profiles of phosphorylation ratios across stages of disease. Eight of 11 investigated sites were hyperphosphorylated and associated with SUVR measures from [18F]GTP1 and amyloid PET. Novel sites 111, 153, and 208 may be relevant biomarkers for AD diagnosis to complement tau hyperphosphorylation measures on previously established sites 181, 205, 217, and 231. Hypophosphorylation was detected on residues 175, 199, and 202, and was inversely associated with [18F]GTP1 and amyloid PET. Conclusion: Hyperphosphorylated and hypophosphorylated forms of tau are associated with AD pathologies, and due to their different site-specific profiles, they may be used in combination to assist with staging of disease.
Diabetes Mellitus, Elevated Hemoglobin A1c, and Glycated Albumin Are Associated with the Presence of All-Cause Dementia and Alzheimer’s Disease: The JPSC-AD Study
Authors: Noguchi-Shinohara Moeko ,   on behalf of the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group, Yuki-Nozaki Sohshi , Abe Chiemi , Mori Ayaka , Horimoto Mai , Yokogawa Masami , Ishida Natsuko , Suga Yukio , Ishizaki Junko , Ishimiya Mai , Nakamura Hiroyuki , Komai Kiyonobu , Nakamura Hiroyuki , Shibata Mao , Ohara Tomoyuki , Hata Jun , Ninomiya Toshiharu , Yamada Masahito
Published: November 2021

Background: Glucose dysmetabolism is an important risk factor for dementia. Objective: We investigated the associations of diabetes mellitus, the levels of glycemic measures, and insulin resistance and secretion measures with dementia and its subtypes in a cross-sectional study. Methods: In this study, 10,214 community-dwelling participants were enrolled. Hemoglobin A1c (HbA1c), the homeostasis model assessment (HOMA) for insulin resistance (HOMA-IR), the HOMA of percent β-cell function (HOMA-β), and the glycated albumin (GA) was evaluated. The associations of each measure with Alzheimer’s disease (AD) and vascular dementia (VaD) were investigated. Results: The multivariable-adjusted odds ratios (ORs) of AD were significantly higher in participants with diabetes mellitus than in those without diabetes (1.46 [95% CI: 1.08–1.97]). Higher HbA1c levels were significantly associated with AD at diabetes (≥6.5%) and even at prediabetes (5.7 %–6.4 %) levels; multivariable-adjusted ORs for AD in participants at the diabetes level were 1.72 (95% CI: 1.19–2.49), and those in participants at the prediabetes level were 1.30 (95% CI: 1.00–1.68), compared with those in normal participants. Moreover, higher GA levels were associated with AD. No associations were observed between the diabetic status or the levels of glycemic measures and VaD. In addition, no significant relationships were observed between insulin resistance and secretion measurements and AD and VaD. Conclusion: Our findings indicate that diabetes mellitus and hyperglycemia are significantly associated with AD, even in individuals at the prediabetes level.