bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetics of Nonalcoholic Fatty Liver Disease: From Pathogenesis to Therapeutics
Authors: Sookoian Silvia , Pirola Carlos
Published: March 2019

Here, the authors review the remarkable genetic discoveries that have illuminated the biology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The authors integrate genes associated with NAFLD and NASH into regulatory pathways to elucidate the disease pathogenesis. They review the evidence for molecular mediators of chronic liver damage, which suggests that convergent pathophenotypes, including inflammation and fibrosis, share common genetic modifiers. They further demonstrate that genes involved in the genetic susceptibility of NAFLD and NASH participate in cross-phenotype associations with diseases of the metabolic syndrome, including type 2 diabetes, obesity, and cardiovascular disease. However, immune-related loci associated with NAFLD and NASH exhibit some level of pleiotropy influencing disparate phenotypes, such as premature birth or sepsis. They finally focus on the translation of current genetic knowledge of NAFLD and NASH toward precision medicine. They provide evidence of genetic findings that can be leveraged to identify therapeutic targets.
D-Dimer Measured at Diagnosis of Venous Thromboembolism is Associated with Risk of Major Bleeding
Authors: Johnsen Håkon , Hindberg Kristian , Bjøri Esben , Brodin Ellen , Brækkan Sigrid , Morelli Vânia , Hansen John-Bjarne
Published: March 2019

Identification of patients at risk of major bleeding is pivotal for optimal management of anticoagulant therapy in venous thromboembolism (VTE). Studies have suggested that D-dimer may predict major bleeding during anticoagulation; however, this is scarcely investigated in VTE patients. We aimed to investigate the role of D-dimer, measured at VTE diagnosis, as a predictive biomarker of major bleeding. The study population comprised 555 patients with a first community-acquired VTE (1994–2016), who were identified among participants from the Tromsø study. Major bleeding events were recorded during the first year after VTE and defined according to the criteria of the International Society on Thrombosis and Haemostasis. Cox-regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for age, sex, and duration of anticoagulant therapy. In total, 29 patients experienced major bleeding (incidence rate: 5.7/100 person-years, 95% CI: 4.0–8.2). The major bleeding risk was highest during the first 3 months, especially in patients with D-dimer ≥8.3 µg/mL (upper 20th percentile), with 28.8 major bleedings/100 person-years (95% CI: 13.7–60.4). Patients with D-dimer ≥8.3 µg/mL had a 2.6-fold (95% CI: 1.1–6.6) higher risk of major bleeding than patients with D-dimer ≤2.3 µg/mL (lower 40th percentile). Major bleeding risk according to D-dimer ≥8.3 versus ≤2.3 µg/mL was particularly pronounced among those with deep vein thrombosis (HR: 4.6, 95% CI: 1.3–16.2) and provoked events (HR: 4.2, 95% CI: 1.0–16.8). In conclusion, our results suggest that D-dimer measured at diagnosis may serve as a predictive biomarker of major bleeding after VTE, especially within the initial 3 months.
Incidence and Outcomes of Severe Anaphylaxis in Paediatric Patients in Atlantic Canada
Authors: Krmpotic Kristina , Weisser Caroline , O'Hanley Alexandra , Soder Christian
Published: March 2019

Little is known about severe anaphylaxis in the pediatric population. In this retrospective cohort study, we aimed to describe the characteristics of children who required admission from an outpatient setting to one of two Pediatric Intensive Care Units in Atlantic Canada with a primary diagnosis of anaphylaxis. During the 10-year study period, there were 12 admissions (58% females) for a population incidence of 2.4 per 100,000 children. Both patients who died were adolescents with a witnessed anaphylaxis event, immediately recognized as such after exposure to a known allergen, with immediate access to epinephrine that was not administered until after cardiorespiratory arrest occurred. This study highlights the high mortality associated with severe anaphylaxis and the ongoing need for education surrounding the early administration of intramuscular epinephrine.
Patient Management Strategies and Long-Term Outcomes in Isolated Distal Deep-Vein Thrombosis versus Proximal Deep-Vein Thrombosis: Findings from XALIA
Authors: Ageno Walter , Mantovani Lorenzo , Haas Sylvia , Kreutz Reinhold , Monje Danja , Schneider Jonas , Bugge Jörg-Peter , Gebel Martin , Turpie Alexander
Published: March 2019

Background Overall, 30 to 50% of lower-limb deep-vein thrombosis (DVT) cases are isolated distal DVT (IDDVT). The recurrent venous thromboembolism (VTE) risk is unclear, leaving uncertainty over optimal IDDVT treatment. We present data on patients with IDDVT and proximal DVT (PDVT) from the prospective, noninterventional XALIA study of rivaroxaban for acute and extended VTE treatment.

Methods Patients aged ≥18 years scheduled to receive ≥3 months' anticoagulation with rivaroxaban or standard anticoagulation were eligible, with follow-up for ≥12 months. We describe baseline characteristics, management strategies, and incidence proportions of VTE recurrence, major bleeding, and all-cause mortality in patients with IDDVT or PDVT, with or without distal vein involvement.

Findings Overall, 1,004 patients with IDDVT and 3,098 with PDVT were enrolled; 641 (63.8%) and 1,683 (54.3%) received rivaroxaban, respectively. Patients with IDDVT were younger and had lower incidences of renal impairment, cancer, and unprovoked VTE than those with PDVT. On-treatment recurrence incidences for IDDVT versus PDVT were 1.0 versus 2.4% (adjusted hazard ratio [HR]: 0.56; 95% confidence interval [CI]: 0.29–1.08), and incidences posttreatment cessation were 1.1 versus 2.1% (adjusted HR: 0.65; 95% CI: 0.32–1.35), respectively. On-treatment major bleeding incidences were 0.9 versus 1.4% and mortality was 0.8 versus 2.2%, respectively. Median treatment duration in patients with IDDVT was shorter than in those with PDVT (102 vs. 192 days, respectively).

Interpretation Patients with IDDVT had fewer comorbidities and were more frequently treated with rivaroxaban than those with PDVT. On-treatment and posttreatment recurrences were less frequent in patients with IDDVT.

Trial registration number: NCT01619007.
Two Cases of Pediatric AQP4-Antibody Positive Neuromyelitis Optica Spectrum Disorder Successfully Treated with Tocilizumab
Authors: Breu Markus , Glatter Sarah , Höftberger Romana , Freilinger Michael , Kircher Karl , Kasprian Gregor , Seidl Rainer , Kornek Barbara
Published: March 2019

B cell depletion with the anti-CD20-antibody rituximab is widely considered treatment of choice for long-term immunotherapy in aquaporin-4 (AQP4)-antibody positive neuromyelitis optica spectrum disorder (NMOSD). However, up to 30% of patients suffer from relapses despite complete B cell depletion. In these cases, the IL6 (interleukin-6)-receptor blocking antibody tocilizumab has been suggested as an alternative. We report two female adolescents with AQP4-antibody positive NMOSD who relapsed under rituximab treatment and clinically stabilized after switching to monthly administrations of tocilizumab. Our data suggest that early escalation of therapy with tocilizumab may lead to stabilization of disease activity in pediatric NMOSD patients who relapse under B cell depletion.
Bridging to Action Requires Mixed Methods, Not Only Randomised Control Trials
Authors: Olsen Wendy
Published: March 2019

Development evaluation refers to evaluating projects and programmes in development contexts. Some evaluations are too narrow. Narrow within-discipline impact evaluations are weaker than multidisciplinary, mixed-methods evaluations. A two-step process leads toward profoundly better arguments in assessing the impact of a development intervention. The first step is setting out the arena for discussion, including what the various entities are in the social, political, cultural and natural environment surrounding the chosen problem. The second step is that, once this arena has been declared, the project and triangulation of data can be brought to bear upon logical arguments with clear, transparent reasoning leading to a set of conclusions. In this second step, we do need scientific methods such as peer review, data and so on, but, crucially, the impact evaluation process must not rest upon a single data type, such as survey data. It is dangerous and undesirable to have the entire validity of the conclusions resting upon randomised control trials, or even a mixture of data types. Different contributions to knowledge exist within the evaluation process, including the interaction of people during action research, ethnography, case-study methods, process tracing and qualitative methods. The cement holding my argument together is that multiple logics are used (retroductive, deductive, and inductive, in particular). Deductive mathematics should not dominate the evaluation of an intervention, as randomised controlled trials on their own lend themselves to worrying fallacies about causality. I show this using Boolean fuzzy set logic. An indicator of high-quality development evaluation is the use of multiple logics in a transparent way.
A non-dimensional parameter for classification of the flow in intracranial aneurysms. I. Simplified geometries
Authors: Asgharzadeh Hafez , Borazjani Iman
Published: March 2019

Non-dimensional parameters are routinely used to classify different flow regimes. We propose a non-dimensional parameter, called Aneurysm number (An), which depends on both geometric and flow characteristics, to classify the flow inside aneurysm-like geometries (sidewalls and bifurcations). The flow inside aneurysm-like geometries can be widely classified into (i) the vortex mode in which a vortex ring is formed and (ii) the cavity mode in which a stationary shear layer acts similar to a moving lid of a lid-driven cavity. In these modes, two competing time scales exist: (a) a transport time scale, Tt, which is the time scale to develop a shear layer by transporting a fluid particle across the expansion region, and (b) the vortex formation time scale, Tv. Consequently, a relevant non-dimensional parameter is the ratio of these two time scales, which is called Aneurysm number: An = Tt/Tv. It is hypothesized, based on this definition, that the flow is in the vortex mode if the time required for vortex ring formation Tv is less than the transport time Tt (An ≳ 1). Otherwise, the flow is in the cavity mode (An ≲ 1). This hypothesis is systematically tested through numerical simulations on simplified geometries and shown to be true through flow visualizations and identification of the main vortex and shear layer. The main vortex is shown to evolve when An ≳ 1 but stationary when An ≲ 1. In fact, it is shown that the flows with An ≲ 1 (cavity mode) are characterized by much smaller fluctuations of wall shear stress and oscillatory shear index relative to flows with An ≳ 1 (vortex mode) because of their quasi-stationary flow pattern (cavity mode) compared to the evolution and breakdown of the formed vortex ring (vortex mode).
Nanostructured carriers as innovative tools for cancer diagnosis and therapy
Authors: Martinelli Chiara , Pucci Carlotta , Ciofani Gianni
Published: March 2019

Cancer accounts for millions of deaths every year and, due to the increase and aging of the world population, the number of new diagnosed cases is continuously rising. Although many progresses in early diagnosis and innovative therapeutic protocols have been already set in clinical practice, still a lot of critical aspects need to be addressed in order to efficiently treat cancer and to reduce several drawbacks caused by conventional therapies. Nanomedicine has emerged as a very promising approach to support both early diagnosis and effective therapy of tumors, and a plethora of different inorganic and organic multifunctional nanomaterials have been ad hoc designed to meet the constant demand for new solutions in cancer treatment. Given their unique features and extreme versatility, nanocarriers represent an innovative and easily adaptable tool both for imaging and targeted therapy purposes, in order to improve the specific delivery of drugs administered to cancer patients. The current review reports an in-depth analysis of the most recent research studies aiming at developing both inorganic and organic materials for nanomedical applications in cancer diagnosis and therapy. A detailed overview of different approaches currently undergoing clinical trials or already approved in clinical practice is provided.
Energy-resolved neutron imaging options at a small angle neutron scattering instrument at the Australian Center for Neutron Scattering
Authors: Tremsin A. S. , Sokolova A. V. , Salvemini F. , Luzin V. , Paradowska A. , Muransky O. , Kirkwood H. J. , Abbey B. , Wensrich C. M. , Kisi E. H.
Published: March 2019

Energy-resolved neutron imaging experiments conducted on the Small Angle Neutron Scattering (SANS) instrument, Bilby, demonstrate how the capabilities of this instrument can be enhanced by a relatively simple addition of a compact neutron counting detector. Together with possible SANS sample surveying and location of the region of interest, this instrument is attractive for many imaging applications. In particular, the combination of the cold spectrum of the neutron beam and its pulsed nature enables unique non-destructive studies of the internal structure for samples that are opaque to other more traditional techniques. In addition to conventional white beam neutron radiography, we conducted energy-resolved imaging experiments capable of resolving features related to microstructure in crystalline materials with a spatial resolution down to ∼0.1 mm. The optimized settings for the beamline configuration were determined for the imaging modality, where the compromise between the beam intensity and the achievable spatial resolution is of key concern.
On two-dimensional self-similar axisymmetric vortices
Authors: Sutyrin G. G.
Published: March 2019

Superpositions of Lamb-Oseen axisymmetric vortices with Gaussian vorticity having zero net circulation and finite kinetic energy in unbounded domain are considered. Their evolution is described by self-similar solutions depending on a certain combination of space, time, and viscous diffusion. It is shown that the structure of a popular self-similar solution for a shielded vortex with Gaussian fluid rotation rate corresponds to two Lamb-Oseen vortices with opposite sign and nearly the same spatial scale. The radial structure of a combined vortex with different spatial scales is well suited for characterization of realistic vortical structures like atmospheric hurricanes. The linear stability of the combined vortex is investigated. The results have important implications for better understanding of vortex structures in two-dimensional flow.
Nut Grower's Guide
Authors: Wilkinson Jennifer
Published: March 2019

Nut growing has become more popular and technology has developed significantly over the last 5 years. This book is the starting point for prospective commercial nut growers – large or small scale, for farmers who want to diversify and also for gardeners interested in growing nut trees in their back yards.
Nut Grower's Guide is the first comprehensive book to growing almonds, cashews, chestnuts, hazelnuts, macadamias, pecans, pistachios and walnuts. All aspects of site selection are covered, from soil and climate to aspect and topography through to previous land use and local pest species. Soil preparation, irrigation, planting and propagating trees are also covered. It covers the cultivation and processing of each of the major nut species and also provides guidance on packaging and the wholesale and retail marketing of nuts in Australia and overseas.
Tropical Dairy Farming
Authors: Moran John
Published: March 2019

Tropical Dairy Farming is a manual designed for use by dairy production advisors working in tropical areas, especially in South-East Asia. It aims to increase the productivity of small holder dairy farmers in the humid tropics by improving the feeding management of their livestock. It shows how to provide dairy cows with cost-effective feeds that match small holder farming systems and discusses the major obstacles to improving feeding management in the humid tropics.
The author shows the benefits and drawbacks of various feed components and the calculation of balanced diets based mainly on forages combined with some supplementary feeding. Diseases and problems associated with unbalanced diets are also covered, as well as important information on growing and conserving quality forages as silage.
The book draws on examples from a variety of countries including Indonesia, Malaysia, Thailand, Vietnam, China, East Timor and the Philippines.
Producing Table Olives
Authors: Kailis Stan , Harris David
Published: March 2019

Australia has the ideal conditions for growing and processing table olives. In a climate where the majority of table olives eaten by Australians are imported, real opportunities exist for a domestic table olive industry. Attention to quality and safety will ensure that Australian table olive producers are in a position to tackle and make inroads into the international export market.
The aim of this manual is to provide olive growers and processors with internationally based guidelines for ensuring the quality and safety of processed table olives. This manual covers all aspects essential for the production of safe, nutritious and marketable table olives including site selection, recommended varieties, pest and disease control, primary and secondary processing, and quality and safety testing.
Working Sheep Dogs
Authors: Williams Tully
Published: March 2019

Working Sheep Dogs examines and illuminates every aspect of the high-quality working dog. It provides a detailed discussion of the principles behind the training of working dogs, and reveals little-known methods for training and handling sheep dogs in the most effortless manner.
The text is divided into six major sections covering the instincts of the working dog, breeding, principles of training, methods of training, handling livestock and sheep dog trials. Photographs and line drawings help to illustrate best techniques when training dogs, such as how to teach dogs to cast, muster and drive.
Containing the first comprehensive breakdown and analysis of the instincts of the working dog, and discussing the various principles and methods of their breeding, this book is a practical reference for farmers and stockmen, hobby and lifestyle farmers, sheep dog trial competitors and breeders of working dogs.
Breeding Stud Sheep
Authors: Long Murray
Published: March 2019

Breeding Stud Sheep shows how to establish and manage a successful sheep stud. All aspects of stud breeding are covered, including where and how to buy your sheep, selecting the right breeding stock for your stud, flock management, nutrition, disease control, lambing problems, showing sheep, promotion and marketing, and selling stud genetics. The detailed step-by-step strategies will give the reader the ability to develop alternative approaches that best suit their situation.
It also explains how new initiatives such as performance recording, DNA testing and modern reproductive techniques can be integrated with the old, time-honoured traditions of sheep breeding.
Profiles of highly recognised stud breeders are included, detailing how they started and the strategies they have used to grow their stud sheep operations over many years.
This book will help new breeders avoid the pitfalls and mistakes that can occur when starting a new stud venture, and show how to succeed in what is ultimately a tough but very rewarding industry.
Internal representation of hippocampal neuronal population spans a time-distance continuum
Authors: Haimerl Caroline , Angulo-Garcia David , Villette Vincent , Reichinnek Susanne , Torcini Alessandro , Cossart Rosa , Malvache Arnaud
Published: March 2019

The hippocampus plays a critical role in episodic memory: the sequential representation of visited places and experienced events. This function is mirrored by hippocampal activity that self organizes into sequences of neuronal activation that integrate spatiotemporal information. What are the underlying mechanisms of such integration is still unknown. Single cell activity was recently shown to combine time and distance information; however, it remains unknown whether a degree of tuning between space and time can be defined at the network level. Here, combining daily calcium imaging of CA1 sequence dynamics in running head-fixed mice and network modeling, we show that CA1 network activity tends to represent a specific combination of space and time at any given moment, and that the degree of tuning can shift within a continuum from 1 day to the next. Our computational model shows that this shift in tuning can happen under the control of the external drive power. We propose that extrinsic global inputs shape the nature of spatiotemporal integration in the hippocampus at the population level depending on the task at hand, a hypothesis which may guide future experimental studies.
Isotopes from fossil coronulid barnacle shells record evidence of migration in multiple Pleistocene whale populations
Authors: Taylor Larry D. , O’Dea Aaron , Bralower Timothy J. , Finnegan Seth
Published: March 2019

Significance

Migration has long been hypothesized to have played a critical role in baleen whale evolution, but fossil constraints on the history of migration are sparse. Here we provide evidence that the oxygen isotope composition of modern whale barnacle shells reliably records migration pathways. We also analyze fossil whale barnacle shells from three Pleistocene localities and show that they display isotope profiles similar to those of modern specimens. Our results indicate the presence of migration among all three ancient whale populations studied and point to the possibility of reconstructing changes in migratory behaviors from the Pliocene to the present.
Earthquake swarms and slow slip on a sliver fault in the Mexican subduction zone
Authors: Fasola Shannon L. , Brudzinski Michael R. , Holtkamp Stephen G. , Graham Shannon E. , Cabral-Cano Enrique
Published: March 2019

Significance

We provide an interpretation for the interaction of crustal faults, clusters of earthquakes (swarms), and slow slip (a slower form of fault rupture) in southern Mexico. Our observations indicate that swarms and slow slip are occurring on a sliver fault in the overriding plate that allows the oblique plate convergence to be separated into a trench-perpendicular and -parallel motion on the subduction interface and sliver fault, respectively. We propose the sliver fault provides a natural pathway for buoyant fluids attempting to migrate upward after being released from the downgoing plate. Thus, sliver faults could be responsible for the downdip end of the seismogenic zone by creating drier conditions on the subduction interface trenchward of the sliver fault.
Crowd wisdom enhanced by costly signaling in a virtual rating system
Authors: Tchernichovski Ofer , Parra Lucas C. , Fimiarz Daniel , Lotem Arnon , Conley Dalton
Published: March 2019

Costly signaling theory was developed in both economics and biology and has been used to explain a wide range of phenomena. However, the theory’s prediction that signal cost can enforce information quality in the design of new communication systems has never been put to an empirical test. Here we show that imposing time costs on reporting extreme scores can improve crowd wisdom in a previously cost-free rating system. We developed an online game where individuals interacted repeatedly with simulated services and rated them for satisfaction. We associated ratings with differential time costs by endowing the graphical user interface that solicited ratings from the users with “physics,” including an initial (default) slider position and friction. When ratings were not associated with differential cost (all scores from 0 to 100 could be given by an equally low-cost click on the screen), scores correlated only weakly with objective service quality. However, introducing differential time costs, proportional to the deviation from the mean score, improved correlations between subjective rating scores and objective service performance and lowered the sample size required for obtaining reliable, averaged crowd estimates. Boosting time costs for reporting extreme scores further facilitated the detection of top performances. Thus, human collective online behavior, which is typically cost-free, can be made more informative by applying costly signaling via the virtual physics of rating devices.
Scale-dependent interactions between tree canopy cover and impervious surfaces reduce daytime urban heat during summer
Authors: Ziter Carly D. , Pedersen Eric J. , Kucharik Christopher J. , Turner Monica G.
Published: March 2019

As cities warm and the need for climate adaptation strategies increases, a more detailed understanding of the cooling effects of land cover across a continuum of spatial scales will be necessary to guide management decisions. We asked how tree canopy cover and impervious surface cover interact to influence daytime and nighttime summer air temperature, and how effects vary with the spatial scale at which land-cover data are analyzed (10-, 30-, 60-, and 90-m radii). A bicycle-mounted measurement system was used to sample air temperature every 5 m along 10 transects (∼7 km length, sampled 3–12 times each) spanning a range of impervious and tree canopy cover (0–100%, each) in a midsized city in the Upper Midwest United States. Variability in daytime air temperature within the urban landscape averaged 3.5 °C (range, 1.1–5.7 °C). Temperature decreased nonlinearly with increasing canopy cover, with the greatest cooling when canopy cover exceeded 40%. The magnitude of daytime cooling also increased with spatial scale and was greatest at the size of a typical city block (60–90 m). Daytime air temperature increased linearly with increasing impervious cover, but the magnitude of warming was less than the cooling associated with increased canopy cover. Variation in nighttime air temperature averaged 2.1 °C (range, 1.2–3.0 °C), and temperature increased with impervious surface. Effects of canopy were limited at night; thus, reduction of impervious surfaces remains critical for reducing nighttime urban heat. Results suggest strategies for managing urban land-cover patterns to enhance resilience of cities to climate warming.
Salmonella
SiiE prevents an efficient humoral immune memory by interfering with IgG
+
plasma cell persistence in the bone marrow
Authors: Männe Christian , Takaya Akiko , Yamasaki Yuzuru , Mursell Mathias , Hojyo Shintaro , Wu Tsung-Yen , Sarkander Jana , McGrath Mairi A. , Cornelis Rebecca , Hahne Stefanie , Cheng Qingyu , Kawamoto Tadafumi , Hiepe Falk , Kaufmann Stefan H. E. , Yamamoto Tomoko , Radbruch Andreas , Tokoyoda Koji
Published: March 2019

Significance

Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE of
Salmonella
is required to prevent an efficient humoral immune response against the pathogen by selectively reducing the number of IgG-secreting plasma cells in the BM. Attenuated SiiE-deficient
Salmonella
induces high titers of specific
Salmonella
-specific IgG and qualifies as an efficient vaccine against
Salmonella
. A SiiE-derived peptide with homology to laminin β1 is sufficient to ablate IgG-secreting plasma cells from the BM, identifying laminin β1 as a component of niches for IgG-secreting plasma cells in the BM.
Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers
Authors: Ji Zhe , He Lizhi , Regev Aviv , Struhl Kevin
Published: March 2019

Using an inducible, inflammatory model of breast cellular transformation, we describe the transcriptional regulatory network mediated by STAT3, NF-κB, and AP-1 factors on a genomic scale. These proinflammatory regulators form transcriptional complexes that directly regulate the expression of hundreds of genes in oncogenic pathways via a positive feedback loop. This transcriptional feedback loop and associated network functions to various extents in many types of cancer cells and patient tumors, and it is the basis for a cancer inflammation index that defines cancer types by functional criteria. We identify a network of noninflammatory genes whose expression is well correlated with the cancer inflammatory index. Conversely, the cancer inflammation index is negatively correlated with the expression of genes involved in DNA metabolism, and transformation is associated with genome instability. We identify drugs whose efficacy in cell lines is correlated with the cancer inflammation index, suggesting the possibility of using this index for personalized cancer therapy. Inflammatory tumors are preferentially associated with infiltrating immune cells that might be recruited to the site of the tumor via inflammatory molecules produced by the cancer cells.
Ancient trash mounds unravel urban collapse a century before the end of Byzantine hegemony in the southern Levant
Authors: Bar-Oz Guy , Weissbrod Lior , Erickson-Gini Tali , Tepper Yotam , Malkinson Dan , Benzaquen Mordechay , Langgut Dafna , Dunseth Zachary C. , Butler Don H. , Shahack-Gross Ruth , Roskin Joel , Fuks Daniel , Weiss Ehud , Marom Nimrod , Ktalav Inbar , Blevis Rachel , Zohar Irit , Farhi Yoav , Filatova Anya , Gorin-Rosen Yael , Yan Xin , Boaretto Elisabetta
Published: March 2019

Significance

Historians have long debated the role of climate in the rise and fall of empires of the 1st millennium CE. Drastic territorial contraction of the Byzantine Empire, societal decline, and beginning of the European Middle Ages have generally been linked to the Islamic conquests of the seventh century. This multidisciplinary archaeological investigation of trash mounds in the Negev Desert establishes the end date of organized trash management in the Byzantine-period city of Elusa and demonstrates urban collapse a century before the Islamic transition. Our findings, taken together with other evidence for Byzantine urban dysfunction, the Justinianic Plague, and recent research on the Late Antique Little Ice Age, flesh out the impact of the sixth century on broad historical trajectories.
Anticipating and designing for policy effectiveness
Authors: Bali Azad Singh , Capano Giliberto , Ramesh M
Published: March 2019

The new design orientation in the policy sciences has placed renewed emphasis on problem-solving and developing effective public policies. In this paper, we contribute to this scholarship by presenting a policy framework on anticipating effective policies. We argue that anticipation – that is, foreseeing the future and preparing for it – must be central to how a policy is designed, executed and assessed. Anticipating policy effectiveness requires a careful understanding of the problem and its root causes, as well as selection and utilization of the most ‘appropriate’ policy instrument(s) to solve it. We consider ‘appropriateness’ along three dimensions – analytical, political and operational – in two different respects: choice of policy tools and the capacity of the implementing agency.
Melodrama
Authors: Rooney Monique
Published: March 2019

Melodrama is a mixed or transmedial artform that, having migrated from stage to film, television and digital screens, typically combines plastic arts (tableau, mise en scène, filmic close-up, sculptural poses) with performative arts (stage and screen acting, declamation, singing, orchestral or other music). It emerged first in the 18th century when Jean-Jacques Rousseau wrote and composed his “scène lyrique” Pygmalion, a formally innovative and experimental adaptation of the story from Ovid’s Metamorphoses. In the context of the speculative and neoAristotelian ideas that Rousseau contributed to public debate about the significance of imitation or mimesis in the development of language, Rousseau’s foundational melodrama represented the coming-to-life of Pygmalion’s beloved statue, Galatea, as a mimetic scene in which metamorphosis takes place through the statue’s responsiveness to the artist and vice versa. More than simply a theme, imitation is intrinsic to the musical-dramatic and, thus, transmedial structure of the ur-melodrama, through which the alternation of spoken lyric with musical phrasing was intended to draw attention to the mimetic role of vocal accent within the arrangement. This aesthetic structure opened the possibility of representing a diversity of voices on the metropolitan stage and beyond. Since its Enlightenment-era beginnings, the mixed form of melodrama has persisted even as it has been transformed in its itinerary from the 18th century to the early 21st century, transmedially adapting to new modalities and formats as it has moved from stage to print formats and then to film, television, and digital platforms. The transmedial form and reach of melodrama is discernible in latter-day performance and film, in which the mixed form—particularly vocal accent, melody, and gesture—continue to disrupt normative identities and hegemonic systems.
The Influence of English Literature and Language on Ōe Kenzaburō, Murakami Haruki, and other Japanese Novelists
Authors: Abe Masahiko
Published: March 2019

Ōe Kenzaburō and Murakami Haruki are known for their persistent interests in various authors of world literature, especially those writing in English. From their early days, they read novels in English, a custom that helped them to distance themselves from traditional Japanese literature; they thus cultivated modes of writing free from the aesthetics and ways of thinking cherished by their predecessors. Several authors had great impacts on their literary views; in Ōe’s case it was William Blake, in Murakami’s F. Scott Fitzgerald. The styles of both Japanese authors were influenced by their encounters with the English language. The issue is not purely linguistic; alternative modes of writing inevitably bring about changes in narrative styles, moods, characterization, and even a fundamental sense of values that underlies the fictional world. Ōe and Murakami unmistakably played definitive roles in postwar Japanese literature. Their responses to the world that surrounded Japan after the war offer a way to understand the psyche of the Japanese people in the 20th and 21st centuries.

American influence can be observed in many other novelists writing after the 1980s, too, including Yasuo Tanaka’s Somewhat Crystal (Nantonaku Kurisutaru), together with Murakami Ryu and Yamada Eimi. The novel is often seen to mark the onset of postmodernism in Japan, as it presents an extreme case of consumption-oriented life, which, combined with fascination with imported cultural icons, typifies Japanese reception of the West, particularly America. Significantly, Tanaka’s novel was endorsed by the conservative critic Jun Etō and led to the nullification of the border between traditional and popular literatures.
Humanitarian Journalism
Authors: Bunce Mel , Scott Martin , Wright Kate
Published: March 2019

Humanitarian journalism can be defined, very broadly, as the production of factual accounts about crises and issues that affect human welfare. This can be broken down into two broad approaches: “traditional” reporting about humanitarian crises and issues, and advocacy journalism that aims to improve humanitarian outcomes. In practice, there is overlap between the two approaches. Mainstream journalists have long helped to raise awareness and funds for humanitarian crises, as well as provide early emergency warnings and monitor the treatment of citizens. Meanwhile, aid agencies and humanitarian campaigners frequently subsidize or directly provide journalistic content.

There is a large research literature on humanitarian journalism. The most common focus of this research is the content of international reporting about humanitarian crises. These studies show that a small number of “high-profile” crises take up the vast majority of news coverage, leaving others marginalized and hidden. The quantity of coverage is not strongly correlated to the severity of a crisis or the number of people affected but, rather, its geopolitical significance and cultural proximity to the audience. Humanitarian journalism also tends to highlight international rescue efforts, fails to provide context about the causes of a crisis, and operates to erase the agency of local response teams and victims. Communication theorists have argued that this reporting prevents an empathetic and equal encounter between the audience and those affected by distant suffering. However, there are few empirical studies of the mechanisms through which news content influences audiences or policymakers. There are also very few production studies of the news organizations and journalists who produce humanitarian journalism. The research that does exist focuses heavily on news organizations based in the Global North/West.
Science Journalism
Authors: Guenther Lars
Published: March 2019

Science journalism is a specialized form of journalism predominantly covering issues such as science, medicine, and technology; it only professionalized in the second half of the 20th century. For many people, print, audiovisual and online media are the main source they use to get to know something about these fields; hence, science journalism has an important role for the society. However, when looking at science journalism and the research in that area more closely, then a variety of different approaches paint a rather dark picture. Firstly, there is a lot of research criticizing science journalism and science journalists. What these studies focus on is science journalists’ work and role for the society, their routines and practices, their reporting on specific scientific issues, as well as the relationship between journalists and scientists. Secondly, in some countries, science journalism seems to be in a crisis due to increasing digitization and changing media landscapes. Science journalism is declining in these countries and many journalists have lost their jobs. However, assessing the quality and appropriateness of science journalism should be based on journalistic and not on scientific criteria, and these criteria should be used when trying to describe what science journalism is and what not, how science journalism operates and how not, and how best to describe the role science journalism has for the society. In addition, although increasing digitization may change routines and practices of science journalists, these specialized journalists may be able to adapt to new media landscapes and still maintain their important role for the society as the most disinterested source that informs about science, medicine, and technology.
Communicating About Water Security Under a Changing Climate
Authors: Hurlimann Anna , Bell Sarah
Published: March 2019

Some of the most significant impacts of climate change are likely to be felt in water resources management, but climate change is not the only uncertainty facing water managers and policymakers. The concept of water security has emerged to address social, economic, political, and environmental factors, as well as the physical determinants of water availability. There are significant challenges for communicating about water security under a changing climate. Water security shares many of the characteristics of climate change with regards to communication. It is a complex concept involving interactions between dynamic human and natural systems, requiring public deliberation and engagement to inform political debate and to facilitate behavioral and cultural change. Knowledge and values about water and climate change are communicated through material experiences as well as through language. Communication about water security and climate change takes many forms, which can be characterized as five key modes—policy, communication campaigns, media, cultures, and environments. More effective communication about climate change and water is needed across these different modes to support meaningful participation and deliberation in policy decisions by a wide range of stakeholders. Integrating climate change into communication campaigns about water security provides opportunities to challenge and reframe traditional formulations of the role of water in society and culture and how to manage water in human settlements, the economy, and the environment. The central challenge for communicating the impacts of climate change on water scarcity lies in the complex interactions between society, policy, technology, infrastructure, the economy, and the environment in modern water systems. Different modes of communication are useful to enable public and stakeholder engagement in understanding the issues and making decisions about how to ensure water security in a changing society and environment.
HIV and AIDS in Africa: Global Politics and Domestic Consequences
Authors: Whiteside Alan
Published: March 2019

AIDS is a new disease that was first recorded in 1981. In the 1980s and early 1990s, there were concerns that it would decimate populations; prevention was slow to take hold, and there was no cure. By the mid-1990s it was clear, in the developed world, that it would be mostly contained to specific populations. Effective but expensive treatment was unveiled in 1996. However, in Africa there were fears of a continent-wide epidemic. AIDS emerged in central Africa (HIV1) and west Africa (HIV2) and spread from there. In the 1990s it reached southern Africa, the current epicenter.

It has become evident that AIDS has not meant the collapse of economies and nations or the hollowing out of populations. Treatment options mean people can live normally provided they adhere to the drug regime, but they are costly. The worst epidemic is in the southern cone of Africa. Here it continues to have political consequences, although causality is hard to ascribe.

Unique features of the disease are that the modes of transmission include its geographic location and the excessive involvement of donors in the response; the lack of African ownership makes it a global political problem. At the moment the lives of millions of Africans depend on the generosity of the West, and that future is uncertain. AIDS is a greater challenge to southern and eastern African states than anywhere in Africa and indeed the world. The international engagement particularly in the provision of treatment means the disease has global political ramifications.
Trade and Culture
Authors: Chase Kerry A.
Published: March 2019

Government policies to protect and promote national culture are a perennial issue in the trading system. Controversy over trade and culture, in almost every instance, swirls around entertainment media—mainly movies, television, video, and music. The object of contention is that many states employ an assortment of financial, trade, and regulatory measures to subsidize locally produced entertainment, restrict imports, and favor national content over foreign content. Such measures often impede trade, pitting commercial interests in open markets and free choice against calls for state action to mitigate trade’s social repercussions.

Differing perspectives on the motives behind these policies typify disputes over trade and culture. In one view, state regulation of entertainment media is cultural policy, an essential means of preserving a nation’s identity, culture, and way of life. From another vantage point, these policies are backdoor protectionism, a handout to local business and labor under the guise of cultural preservation. The problem of trade and culture therefore raises basic questions about politics: Why do states subsidize production and restrict imports? What drives political demands for trade protection and government aid? How can variation in policy responses be understood?

In the World Trade Organization (WTO), disputes over trade and culture center on two related issues. The first is inclusion of a “cultural exception” in trade rules to green-light, on cultural grounds, state actions that interfere with trade in entertainment media. Although there is no cultural exception in the WTO, pressure to accommodate the “specificity” of entertainment media as a cultural phenomenon has complicated trade negotiations and at times required give and take to placate the opposing sides. The second issue is policy liberalization in entertainment media, which has lagged behind market opening in many other goods and services. Deadlock over trade and culture has inspired some WTO members to explore other options: the European Union (EU) and Canada spearheaded the push for a Convention on Cultural Diversity, and the United States has pursued policy liberalization in a series of free trade agreements. Important political questions again crop up: Why has culture stalemated the WTO, and why haven’t trade linkages like those for health safety standards been institutionalized for trade and culture? Why do international political alignments on this problem form as they do? What explains the design of trade rules for entertainment media, and what is the trade regime’s impact on state policy? The age-old conflict over trade and culture continues to play out and shows no signs of abating.
Globalization and Regionalism in Africa
Authors: Carmody Pádraig
Published: March 2019

Globalization, or increased interconnectedness between world regions, is a dialectical and recursive phenomenon that consequently tends to deepen through time as one set of flows sets off other related or counterflows. This is evident in the history of the phenomenon in Africa, where transcontinental trade, and later investment, were initially small but have grown through different rounds including slavery, colonialism, neocolonialism, and the early 21st-century era of globalization. However, globalization on the continent, as in other places, is not unilinear and has generated a variety of “regional responses” in terms of the construction of organizations such as the African Union and other more popularly based associations. The phenomenon of globalization on the continent is deepening through the information technology “revolution,” which also creates new possibilities for regional forms of association.