bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Image Processing Technology in the Visual Design of Motion Health under the Background of Wireless Communication: Take Swimming as an Example
Authors: Wang Juan , Liu Xu
Published: July 2022

Exercise is an active means to improve the body’s immune function, resist disease invasion, and prolong life. Research data shows that healthy people who exercise regularly have better cellular and humoral immunity than ordinary people. Although physical exercise can strengthen the body, unscientific physical exercise can also cause harm to the body. Contingencies in sports add to the complexity of medical care. In recent years, people pay more and more attention to sports health, and the development of information technology can enable experts to use sports health visualization technology to carry out scientific physical exercise, reduce medical accidents, and ensure sports health, which has become a consensus. As an important technology in the field of sports health visualization, image processing technology has attracted more and more attention. Image processing technology is realized with the help of computer vision technology. It uses cameras, computers, collectors, and other equipment instead of human eyes to monitor and identify the catalogue, collect images, and then process and analyze the images. Image processing technology has played a very important role in sports emergencies. This paper studies the image processing technology in the field of sports health visualization and takes swimming as an example to illustrate the role of image processing technology in sports health visual design. Using scientifically designed sensors, data analysis is performed on various images of athletes while swimming, and exercise recommendations are continued based on the principles of exercise science. According to the test results, the visual target recognition rate during swimming has reached a high level, which also greatly improves the scientificity of athletes during exercise.
[Retracted] Expression of Long Nonencoding Ribonucleic Acid SNHG20 in Colon Cancer Tissue in Its Influences on Chemotherapeutic Sensitivity of Colon Cancer Cells
Authors: Cao Wenbin , Zhang Bo , Liu Yang
Published: July 2022

Noncoding RNA (ncRNA) is a kind of RNA that plays a key role in a variety of biological processes, illnesses, and tumours despite the fact that it cannot be translated into proteins. The HT29 colon cancer cell line was utilized to create a 5‐FU drug‐resistant cell strain (control group), a lentivirus SNHG20 carrier (OE‐SNHG20 group), and an SNHG20 shRNA carrier (SNHG20 shRNA carrier group) (SE‐SNHG20 group). To determine the expression of cell SNHG20, a real‐time quantitative reverse transcription‐polymerase chain reaction (RT‐qPCR) was utilized, and cholecystokinin‐octapeptide (CCK‐8) was used to detect the difference in 5‐FU inhibitory concentration 50. The goal of the study was to see how variations in long nonencoding ribonucleic acid (lncRNA) SNHG20 expression affect colon cancer cell 5‐fluorouracil (5‐FU) chemotherapeutic sensitivity by collecting colon cancer and normal para cancer tissues and analysing the differences in SNHG20 expression. The ability of cell cladogenesis was tested using platform cladogenesis. Cell apoptosis was detected using flow cytometry. Western blots revealed the presence of protein phosphatidylinositol kinase (PI3K), protein kinase B (AKT), caspase‐3, e‐cadherin, and matrix metalloproteinase 9 (MMP‐9) enzymes. The findings revealed that SNHG20 expression was considerably upregulated (P < 0.05) in colon cancer tissue and 5‐FU drug‐resistant colon cancer cells. Cell 5‐FU IC50, cell cladogenesis, cell survival rate, and MMP‐9, P‐PI3K, and P‐AKT expression were all significantly improved. Cell apoptosis and expressions of E‐cadherin and caspase‐3, on the other hand, were considerably decreased (P < 0.05). Cell 5‐FU IC50, cell cladogenesis, cell survival rate, and the expressions of MMP‐9, P‐PI3K, and P‐AKT were all significantly lower in the SE‐SNHG20 group, although cell apoptosis and the expressions of E‐cadherin and caspase‐3 were significantly higher (P < 0.05). The results revealed that lncRNA SNHG20 could inhibit the chemotherapeutic sensitivity of colon cancer cells to 5‐FU by regulating PI3K/AKT pathways. The inhibition of lncRNA SNHG20 expression could promote the apoptosis and proliferation of 5‐FU‐resistant colon cancer cells.
Intelligent Application of Raw Material Supply Chain Planning System Based on Genetic Algorithm
Authors: Xu Feng , Zhang Yu-Meng , Su Yi , Li Jia , Zhu Jia-Ming
Published: July 2022

For the ordering and transportation of raw materials of production enterprises, an intelligent supply chain planning system based on genetic algorithms has been researched and developed. Based on the consideration of multicycle and multiraw materials, by constructing a multiobjective function, taking into account the optimal supplier, the optimal economic ordering scheme, and the minimum loss transshipment scheme, an optimal supply planning model based on genetic algorithm is proposed, and the optimal supply chain combination of the next 24 cycles is predicted by using the model, and its applicability is verified. The study shows that the supply chain planning system has good operation convenience, fast, intuitive, practical application effect of the function and can adapt to modern intelligent logistics and transportation.
Effect of Acupuncture along Meridians on Pain Degree and Treatment of Acute Lumbar Sprain
Authors: Li Yi , Chen Xiaokai , Li Lvping , Zeng Feixiang , Li Juntao , Lu Lan
Published: July 2022

Aim. This study is aimed at investigating the effect of acupuncture along meridians on pain degree and treatment of acute lumbar sprain. Methods. A total of 96 patients with acute lumbar sprain from May 2019 to March 2021 in our hospital were selected and divided into the study and control groups. The patients in the control group were administered conventional western medicine and massage therapy, while the study group underwent acupuncture along meridians based on the control group. The therapeutic effect, visual analogue scale (VAS), Roland-Morris Disability Questionnaire (RMDQ), and lumbar range of motion (ROM) scores, emG inversion times, emG amplitude of the sacrospinalis muscle, and the serum TNF-α and IL-6 levels were determined. Results. The total effective rate of the study group was significantly higher than that of the control group. After treatment, the VAS, RMDQ, and ROM scores of the study group were significantly lower than those of the control group. Before the intervention, the EMG inversion times and the EMG amplitude of the spinous process muscle in the study group were not significantly different from those in the control group. After the intervention, the number and amplitude of EMG reversal in the study group were significantly higher than those in the control group. After the intervention, the serum levels of TNF-α (pg/ml) and IL-6 (pg/ml) in the study group were significantly lower than those in the control group.

C
o
n
c
l
u
s
i
o
n

. Meridian acupuncture for acute lumbar sprain can effectively improve body function, relieve pain, regulate serum inflammatory factors, and improve the overall therapeutic effect.
Data Collection and Evolution Modeling of Fitness Running Based on Digital Information Technology
Authors: Ren Jianchang , Xiao Haili
Published: July 2022

With the development of the times, traditional fitness running data collection methods have shown a series of problems, such as low data accuracy, slow collection speed, and insufficient search ability of modeling algorithms. These problems have led to a sharp rise in the difficulty of building a more accurate fitness running data model. Therefore, this study proposed a set of methods for fitness running data collection and evolution modeling based on digital information technology. First, it filters out the impulse noise during the transmission of the three-dimensional acceleration signal caused by the accidental state change of the technology, by using the data collection method for fitness running based on the digital information platform, relying on a multisensor and median filter algorithm. Second, it filters out the gravitational component of this platform based on the orientation sensor. Then, according to the results of the first step, an algorithm is constructed for the model of fitness running data evolution. The purpose is to expand the search range so that the fitness running data model with better performance can be obtained more effectively. The experimental results show that the method based on digital information technology designed in this study has an overwhelming advantage over the traditional acquisition method, the constructed model is more accurate, and the efficiency of data acquisition is increased by 88%. Therefore, with the aid of digital information technology, the design of the data model can reduce the probability of mold repair and the time consumption of mold trials and reduce the design cost.
Application of Virtual Image Technology in Badminton Teaching in Colleges and Universities
Authors: Dai Jianghong , Shi Yilong
Published: July 2022

Virtual image refers to the unreal image projected by projector, mobile phone, and other projection equipment. Through virtual images, we can explore some scenes that are difficult to observe directly with the naked eye or express fictional images in our minds. At present, the technology is widely used in construction industry, tourism industry, and medical system. At present, after the development of efficient physical education in China, schools generally do not pay attention to the specific application of virtual image technology in badminton teaching in colleges and universities in China. This paper analyzes the representative badminton events in China’s physical education, improves the traditional algorithm, optimizes the effective segmentation and recognition algorithm of virtual image technology in motion capture, combines the improved virtual image technology with virtual reality glasses, and compares the accuracy of the virtual image technology proposed in this paper with that of the traditional image technology. The accuracy of the virtual image technology proposed in this paper always remains the first. The practical application in badminton teaching in colleges and universities has achieved good results.
[Retracted] Analysis of the Diagnostic Efficacy of DOTATATE Imaging Combined with CGA and BSP Detection Mode for NEN Patients with Bone Metastasis
Authors: Lei Lei , Du Tao , Yang Jianbo , Cai Liang , Liu Huipan , Chen Yue
Published: July 2022

In order to explore the clinical efficacy of DOTATATE imaging combined with CGA and BSP in the diagnosis of bone metastasis in patients with NENs, a total of 100 NEN patients treated in our hospital from January 2021 to January 2022 were analyzed. All patients are divided into bone metastasis group and nonmetastasis group according to pathological examination results. The differences of DOTATATE imaging, CGA, and BSP are compared, and ROC curves are obtained to analyze the clinical efficacy of the three indicators in single application and combined diagnosis. The results show that AUC, sensitivity, and specificity of DOTATATE, BSP, and CGA combined diagnosis are higher than those of single diagnosis (P < 0.05). It is clearly evident that DOTATATE test, BSP, and CGA can obtain accurate results in the diagnosis of bone metastasis in NEN patients, and those combined diagnosis can improve the diagnostic efficiency.
Low-Intensity Focused Ultrasound Alleviates Chronic Neuropathic Pain-Induced Allodynia by Inhibiting Neuroplasticity in the Anterior Cingulate Cortex
Authors: Wang Bin , Chen Mo-Xian , Chen Shao-Chun , Feng Xiang-Jun , Liao Ye-Hui , Zhao Yun-Xin , Tie Jin-Shan , Liu Yao , Ao Li-Juan
Published: July 2022

Low-intensity focused ultrasound (LIFU) is a potential noninvasive method to alleviate allodynia by modulating the central nervous system. However, the underlying analgesic mechanisms remain unexplored. Here, we assessed how LIFU at the anterior cingulate cortex (ACC) affects behavior response and central plasticity resulting from chronic constrictive injury (CCI). The safety of LIFU stimulation was assessed by hematoxylin and eosin (H&E) and Fluoro-Jade C (FJC) staining. A 21-day ultrasound exposure therapy was conducted from day 91 after CCI surgery in mice. We assessed the 50% mechanical withdrawal threshold (MWT50) using Von Frey filaments (VFFs). The expression levels of microtubule-associated protein 2 (MAP2), growth-associated protein 43 (GAP43), and tau were determined via western blotting (WB) and immunofluorescence (IF) staining to evaluate the central plasticity in ACC. The regions of ACC were activated effectively and safely by LIFU stimulation, which significantly increased the number of c-fos-positive cells (P<0.05) with no bleeding, coagulative necrosis, and neuronal loss. Under chronic neuropathic pain- (CNP-) induced allodynia, MWT50 decreased significantly (P<0.05), and overexpression of MAP2, GAP43, and tau was also observed. After 3 weeks of treatment, significant increases in MWT50 were found in the CCI+LIFU group compared with the CCI group (P<0.05). WB and IF staining both demonstrated a significant reduction in the expression levels of MAP2, GAP43, and tau (P<0.05). LIFU treatment on ACC can effectively attenuate CNP-evoked mechanical sensitivity to pain and reverse aberrant central plasticity.
Aerobic Exercise and Human Visual Cortex Neuroplasticity: A Narrative Review
Authors: Abuleil Dania , Thompson Benjamin , Dalton Kristine
Published: July 2022

There is compelling evidence from animal models that physical exercise can enhance visual cortex neuroplasticity. In this narrative review, we explored whether exercise has the same effect in humans. We found that while some studies report evidence consistent with exercise-induced enhancement of human visual cortex neuroplasticity, others report no effect or even reduced neuroplasticity following exercise. Differences in study methodology may partially explain these varying results. Because the prospect of exercise increasing human visual cortex neuroplasticity has important implications for vision rehabilitation, additional research is required to resolve this discrepancy in the literature.
Numerical Investigation of Hydraulic Fracture Propagation Morphology in the Conglomerate Reservoir
Authors: Xu Zehao , Liu Xiangjun , Liang Lixi
Published: July 2022

The random distribution of gravels makes the conglomerate reservoir highly heterogeneous. A stress concentration occurs at the gravel-matrix interfaces owing to the embedded gravel and affects the local mechanical response significantly, making it difficult to control and predict hydraulic fracture (HF) propagation. The mechanism of HF propagation in conglomerate reservoirs remains unclear; thus, it is difficult to effectively design and treat hydraulic fracturing. Based on the global pore-pressure cohesive zone element (GPPCZ) model method, a two-dimensional (2D) fracture propagation model with flow-stress-damage (FSD) coupling was established to investigate HF nucleation, propagation, and coalescence in conglomerate reservoirs. This model was experimentally verified, and fractal theory was introduced to quantify the complexity of fracture morphology. The microscale interactions of the gravel, matrix, and interface have been taken into consideration during simulating HF propagation accurately in macroscale. The influence of the mechanical properties of gravel, matrix, matrix-gravel interface, and reservoir stress distribution state, on HF morphology (HF length, stimulated reservoir square, and HF complexity morphology), was investigated. Finally, the main factors affecting fracture propagation were analyzed. It was revealed that the difference between the mechanical properties of the gravel and the matrix in the conglomerate rock will affect the geometry of HF to varying degrees. The local behavior of fracture propagation is obviously dominated by the elastic modulus, tensile strength, and the strength for the matrix-gravel interface. However, the propagation of HF at the whole scale is mainly dominated by the horizontal stress state, including the minimum horizontal stress and horizontal stress difference. In addition, the difference in horizontal stress significantly affects the fracturing patterns (deflection, bifurcation, and penetration) when HF encounters gravel. In this study, a simulation method of HF propagation in conglomerate reservoirs is introduced, and the results provide theoretical support for the prediction of HF propagation morphology and plan design of hydraulic fracturing in conglomerate reservoirs.
Mechanical Stretch Promotes Macrophage Polarization and Inflammation via the RhoA‐ROCK/NF‐κB Pathway
Authors: Tu Peng-cheng , Pan Ya-lan , Liang Zhong-qing , Yang Guang-lu , Wu Cheng-jie , Zeng Liang , Wang Li-ning , Sun Jie , Liu Meng-min , Yuan Yong-feng , Guo Yang , Ma Yong
Published: July 2022

Macrophages play an essential role in the pathogenesis of most inflammatory diseases. Recent studies have shown that mechanical load can influence macrophage function, leading to excessive and uncontrolled inflammation and even systemic damage, including cardiovascular disease and knee osteoarthritis. However, the molecular mechanism remains unclear. In this study, murine RAW264.7 cells were treated with mechanical stretch (MS) using the Flexcell‐5000T Tension System. The expression of inflammatory factors and cytokine release were measured by RT‐qPCR, ELISA, and Western blotting. The protein expression of NF‐κB p65, Iκb‐α, p‐Iκb‐α, RhoA, ROCK1, and ROCK2 was also detected by Western blotting. Then, Flow cytometry was used to detect the proportion of macrophage subsets. Meanwhile, Y‐27632 dihydrochloride, a ROCK inhibitor, was added to knockdown ROCK signal transduction in cells. Our results demonstrated that MS upregulated mRNA expression and increased the secretion levels of proinflammatory factors iNOS, IL‐1β, TNF‐α, and IL‐6. Additionally, MS significantly increased the proportion of CD11b+CD86+ and CD11b+CD206+ subsets in RAW264.7 macrophages. Furthermore, the protein expression of RhoA, ROCK1, ROCK2, NF‐κB p65, and IκB‐α increased in MS‐treated RAW264.7 cells, as well as the IL‐6 and iNOS. In contrast, ROCK inhibitor significantly blocked the activation of RhoA‐ROCK and NF‐κB pathway, decreased the protein expression of IL‐6 and iNOS, reduced the proportion of CD11b+CD86+ cells subpopulation, and increased the proportion of CD11b+CD206+ cell subpopulation after MS. These data indicate that mechanical stretch can regulate the RAW264.7 macrophage polarization and enhance inflammatory responses in vitro, which may contribute to activation the RhoA‐ROCK/NF‐κB pathway.
Configuration Generation Method of Ship End Program for Ship Energy Efficiency Management Platform
Authors: Wu Zhongyuan
Published: July 2022

In order to solve the problem of collecting necessary data affecting fuel consumption and building an intelligent energy efficiency system, this paper makes an in-depth study on the management of cross ship energy efficiency on the basis of program configuration generation. Firstly, this paper studies three methods: technology-driven analysis, support vector machine method, and energy efficiency evaluation method. In order to improve the functions of energy management, energy efficiency analysis, and auxiliary decision-making, this paper constructs a comprehensive intelligent scheme for the best ship navigation energy efficiency from the aspects of ship operation guidance, navigation performance evaluation suggestions, and shipping management decision-making, so as to meet the higher-level management needs of interested parties for ship energy efficiency. Among them, energy efficiency online monitoring can collect energy efficiency data and serve the other three functions, mainly monitoring ship energy consumption, environment, navigation, and other parameters. Energy efficiency evaluation is based on the data collected by online monitoring, and the results of ship energy consumption are obtained by using data mining technology. Through experiments and research, under the background of green, efficient, and intelligent ships, ship shore collaboration is an effective way to improve the ship’s energy efficiency management ability. Intelligent ships provide a new development path for strengthening the application service of ship energy efficiency management system.
Recurrent Hypoglycemia Impaired Vascular Function in Advanced T2DM Rats by Inducing Pyroptosis
Authors: Luo Minghao , Hu Yu , Lv Dingyi , Xie Lingyun , Yang Shenglan , Zuo Deyu , Xue Yuzhou , He An
Published: July 2022

Background. Hypoglycemia is a dangerous side effect of intensive glucose control in diabetes. Even though it leads to adverse cardiovascular events, the effects of hypoglycemia on vascular biology in diabetes have not been adequately studied. Methods. Aged Sprague-Dawley rats were fed a high-fat diet and given streptozotocin to induce type 2 diabetes mellitus (T2DM). Acute and recurrent hypoglycemia were then induced by glucose via insulin administration. Vascular function, oxidative stress, and pyroptosis levels in aortic tissue were assessed by physiological and biochemical methods. Results. Hypoglycemia was associated with a marked decrease in vascular function, elevated oxidative stress, and elevated pyroptosis levels in the thoracic aorta. The changes in oxidative stress and pyroptosis were greater in rats with recurrent hypoglycemia than in those with acute hypoglycemia. Conclusions. Hypoglycemia impaired vascular function in aged rats with T2DM by inducing pyroptosis. The extent of injury increased with the duration of blood glucose fluctuation.
[Retracted] Deep Learning‐Based Networks for Detecting Anomalies in Chest X‐Rays
Authors: Badr Malek , Al-Otaibi Shaha , Alturki Nazik , Abir Tanvir
Published: July 2022

X‐ray images aid medical professionals in the diagnosis and detection of pathologies. They are critical, for example, in the diagnosis of pneumonia, the detection of masses, and, more recently, the detection of COVID‐19‐related conditions. The chest X‐ray is one of the first imaging tests performed when pathology is suspected because it is one of the most accessible radiological examinations. Deep learning‐based neural networks, particularly convolutional neural networks, have exploded in popularity in recent years and have become indispensable tools for image classification. Transfer learning approaches, in particular, have enabled the use of previously trained networks’ knowledge, eliminating the need for large data sets and lowering the high computational costs associated with this type of network. This research focuses on using deep learning‐based neural networks to detect anomalies in chest X‐rays. Different convolutional network‐based approaches are investigated using the ChestX‐ray14 database, which contains over 100,000 X‐ray images with labels relating to 14 different pathologies, and different classification objectives are evaluated. Starting with the pretrained networks VGG19, ResNet50, and Inceptionv3, networks based on transfer learning are implemented, with different schemes for the classification stage and data augmentation. Similarly, an ad hoc architecture is proposed and evaluated without transfer learning for the classification objective with more examples. The results show that transfer learning produces acceptable results in most of the tested cases, indicating that it is a viable first step for using deep networks when there are not enough labeled images, which is a common problem when working with medical images. The ad hoc network, on the other hand, demonstrated good generalization with data augmentation and an acceptable accuracy value. The findings suggest that using convolutional neural networks with and without transfer learning to design classifiers for detecting pathologies in chest X‐rays is a good idea.
Network‐Based Pharmacology and Bioinformatics Study on the Mechanism of Action of Gujiansan in the Treatment of Steroid‐Induced Avascular Necrosis of the Femoral Head
Authors: Ren Guo-wu , Wen Shuai-bo , Han Jie , Xu Zhi-wei , Qi Wen , Shang Yu-zhi , Wu Yu-kun
Published: July 2022

Objective. To investigate the main pharmacological basis and mechanism of action of Gujiansan in the treatment of steroid‐induced avascular necrosis of the femoral head (SANFH). Methods. The active constituents and targets of Gujiansan were screened by using TCMSP and other databases, and relevant disease targets were obtained by analyzing the microarray of SANFH in the GEO database. The intersection of the two was taken to obtain the potential targets of Gujiansan for the treatment of SANFH, and key active constituents were screened with the “active constituent‐target” network constructed by the Cytoscape software; then, the STRING database was used to construct the protein interaction network to screen the key targets. The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses of key targets were performed by the DAVID database, and the relationship between the “key active constituent‐key target‐key signaling pathway” was explored. Finally, the molecular docking between key active constituents and key targets was verified. In addition, qPCR detection technology was used to evaluate the preventive and therapeutic effects of key active constituents of Gujiansan in a rat osteoblast model of SANFH to verify the possible mechanism of the effect of Gujiansan in the treatment of SANFH. Results. (1) 106 active constituents and 55 targets were obtained for the treatment of SANFH. (2) Quercetin, luteolin, kaempferol, cryptotanshinone, and naringenin were the key active constituents for the treatment of SANFH. (3) IL1B, STAT3, CAT, PTGS2, and MAPK3 were the key targets for the treatment of SANFH. (4) IL1B, STAT3, CAT, PTGS2, MAPK3, and HMOX1 are key targets in the protein interaction network. (5) DAVID enrichment analysis mainly covers the regulation of DNA‐binding transcription factor activity, positive regulation of cytokine production, and response to oxidative stress and other biological processes, involving IL‐17, AGE‐RAGE, C‐type lectin receptor, and other signaling pathways. (6) Gujiansan is a multitarget and multisignaling pathway for the treatment of SANFH. (7) Good binding activity exists between key active constituents and key targets. Conclusion. This study analyzes the potential mechanism of action of Gujiansan in the treatment of SANFH with network pharmacology, which can provide a reference for the further study of its pharmacological basis and targets.
Effects of Roflumilast on Patients with Chronic Obstructive Pulmonary Disease Treated with Inhaled Corticosteroid/Long-Acting β2 Agonist: A Meta-analysis
Authors: Zeng Shasha , Bai Haibing , Zou Mi
Published: July 2022

Objective. Roflumilast is a novel therapeutic drug for chronic obstructive pulmonary disease (COPD). This study was designed to evaluate the efficacy and safety of roflumilast combining inhaled corticosteroid (ICS)/long-acting β2 agonist (LABA) in treating COPD patients through the meta-analysis. Methods. Randomized controlled trials of roflumilast combining ICS/LABA in treating patients with severe and profound COPD were searched from PubMed, Cochrane Library, and Embase databases from their establishment to February 2022. The quality of included studies was assessed by Cochrane risk bias assessment tool. The main outcomes of these studies should include at least one of the following clinical outcome indicators: forced expiratory volume in one second (FEV1), exacerbation rate, and adverse events (AEs) such as diarrhea, nasopharyngitis, and headache. Results. Six articles were included in the study, including 9,715 patients. Meta-analysis revealed that compared with placebo, roflumilast gained superiority for severe COPD patients treated with ICS/LABA combinations in FEV1 before bronchodilator administration (

MD
=
46.62

, 95% CI (30.69, 62.55),

P
<
0.00001

), FEV1 after bronchodilator administration (

MD
=
45.62

, 95% CI (34.95, 56.28),

P
<
0.00001

), and COPD exacerbation rate (

RR
=
0.90

, 95% CI (0.87, 0.94),

P
=
0.001

). In terms of safety, the incidence of diarrhea, headache, nausea, weight loss, back pain, loss of appetite, and insomnia was notably higher in the roflumilast group than in the placebo group. Conclusion. Roflumilast is suggested to be significantly effective for severe COPD patients with ICS/LABA combination therapy, which reduces the exacerbation rate but also leads to PDE4 inhibitor-related adverse reactions.
A Novel Tool to Predict the Overall Survival of High-Grade Osteosarcoma Patients after Neoadjuvant Chemotherapy: A Large Population-Based Cohort Study
Authors: Huang Zhangheng , Wang Yu , Wu Ye , Guo Chuan , Li Weilong , Kong Qingquan
Published: July 2022

Background. The goal of this study was to discover clinical factors linked to overall survival in patients with high-grade osteosarcoma who had received neoadjuvant therapy and to develop a prognostic nomogram and risk classification system. Methods. A total of 762 patients with high-grade osteosarcoma were included in this study. In the training cohort, Cox regression analysis models were used to find prognostic variables that were independently linked with overall survival. To predict overall survival at 3, 5, and 8 years, a nomogram is created. In addition, in both the internal and external validation cohorts, receiver operating characteristic curves, calibration curves, and decision curve analysis (DCA) were utilized to assess the prediction model’s performance. Results. The age, size of the tumor, and the stage of the disease are all important predictive variables for overall survival. The training and validation cohorts have C-indexes of 0.699 and 0.669, respectively. At the same time, the area under the curve values for both cohorts also showed that the nomogram had good discriminatory power. The calibration curve demonstrated the good performance and predictive accuracy of the model. The DCA results suggest that the nomogram has a wide range of therapeutic applications. Furthermore, a new risk classification system based on the nomogram was established, which allows all patients to be classified into three subgroups as high, middle, and low risk of death. Conclusion. The prognostic nomogram constructed in this study may provide a better precise prognostic prediction for patients with high-grade osteosarcoma after neoadjuvant chemotherapy.
Cultivation of College English Network Autonomous Learning Ability Based on the Multisource Information Fusion Algorithm
Authors: Liu Wenjun
Published: July 2022

With the rapid development of science and technology, the new century has entered an era of ever-changing information. Lifelong learning and lifelong education have become the dominance of a new round of educational concepts. Therefore, it is urgent to cultivate learners’ autonomous learning ability. Self-directed learning has been a major focus of foreign language education in recent years. This research mainly explores the cultivation of college English online autonomous learning ability based on the multisource information fusion algorithm. This research will use a multisource information fusion algorithm to collect factors such as motivation, learning time, and other factors of students’ English learning from multiple dimensions and then evaluate the college English online self-learning ability. The questionnaire on the self-learning ability of college students in the network environment includes five dimensions: understanding of teachers’ teaching objectives and requirements, formulation and planning of learning objectives, effective use of learning strategies, monitoring of the use of learning strategies, and monitoring and evaluation of the learning process. The results of the study found that the highest score of the control class was 96 and the highest score of the experimental class was 86. The average score of the control class was 73.6 and the average score of the experimental class was 78.4, indicating that the average score of the experimental class was 4.8 points higher than that of the control class, and the standard deviations of the two classes were, respectively, 8.05 and 6.51. High-level students are better at using the network for effective learning than low-level students. High-level students are better at choosing learning strategies that suit them than lower level students. The value of sig (2-tailed) in the t-test is 0.004, which is less than 0.05. Therefore, we conclude that there is a significant difference in the posttest results of the two classes, showing a significant difference. This research will help to promote the cultivation of college English online self-learning ability.
Application Value of Nutrition Support Team in Chemotherapy Period of Colon Cancer Based on Internet Multidisciplinary Treatment Mode
Authors: Chen Jianfeng , Wang Bo , Yin Xiaobin , Liang Qifei , Li Yucheng , Xie Xingjiang , Zeng Xuehui
Published: July 2022

Objective. To explore the application value of the nutrition support team in chemotherapy period of colon cancer based on the internet multidisciplinary treatment mode. Methods. For the method of retrospective study, 90 patients with colon cancer admitted to our hospital from August 2018 to August 2020 were selected as the study subjects. They were equally divided into the experimental group (

n
=
45

) and the control group (

n
=
45

) according to the order of initials and the method of parity group. The control group was given conventional nutrition support, and the experimental group was given the nutrition support under the internet multidisciplinary treatment mode. The serum tumor marker levels (CEA and CA19-9), immune function indexes, nutrition indicators, and the incidence of adverse reactions were compared between the two groups before and after intervention. Results. The serum tumor marker levels in the experimental group after intervention were significantly lower than those in the control group (

P
<
0.001

). The immune function indexes in the experimental group after intervention were significantly better than those in the control group (

P
<
0.001

). The nutrition indicators in the experimental group after intervention were significantly better than those in the control group (

P
<
0.001

). The incidence of gastrointestinal adverse reactions above grade 2 in the experimental group was significantly lower than that in the control group (

P
<
0.05

). There were 20 patients with myelosuppression, 2 patients with neurotoxicity, and 1 patient with hand and foot syndrome in the experimental group, while 22 patients with myelosuppression, 4 patients with neurotoxicity, and 2 patients with hand and foot syndrome in the control group, with no significant difference in the incidence of adverse reactions between the two groups (

P
>
0.05

). Conclusion. The nutrition support team under the internet multidisciplinary treatment mode can improve the immune function of chemotherapy patients with colon cancer and enhance their nutritional level, thereby reducing the incidence of adverse reactions and improving the chemotherapy effects.
Investigation of the Effects of Adhesive Materials of Different Types and Thicknesses on Dental Tissue Stress via FEM Analysis
Authors: Yasin Gönder Hakan , Mohammadi Reza , Harmankaya Abdulkadir , Burak Yüksel İbrahim , Seda Gültekin Didem
Published: July 2022

The aim of this study was to investigate the types and thicknesses of adhesive materials used in restorative treatment in dentistry in class I occlusal and class II disto‐occlusal cavities and to examine the effects of stress distribution on enamel, dentin, restoration material, and adhesive material using the finite element stress analysis method. A 3‐dimensional geometry of the tooth was obtained by scanning the extracted 26 numbered upper molar tooth with dental tomography. The 3D geometry obtained by using the Geomagic Design X 2020.0 software was divided into surfaces, and necessary arrangements were made. With the Solidworks 2013 software, 2 different cavity modeling, class I occlusal and class II disto‐occlusal, with a cavity angle of 95 degrees on the 3D model, as well as 10, 30, and 50 micrometers thick, four types of adhesive materials and the modeling of the bulk‐fill composite material on it were made. With finite element stress analysis, the stress distribution was analyzed using the Abaqus software. The materials used in the study are included in the simulation as isotropic linear elastic. Periodontal ligament and jawbone were not included in the analysis. A total of 600 N pressure was applied on the models. In our study, it was observed that the amount of stress on the tooth structures changed when the thickness, elastic modulus, and Poisson ratios of the adhesive material were changed. In addition, when all models are examined, it is seen that when the thickness is increased, more stress is placed on the adhesive material compared to the restoration, while when 50‐micrometer‐thick adhesive material is used, more stress is placed on the restoration compared to the adhesive material.
Antiplasmodial, Antitrypanosomal, and Cytotoxic Effects of Anthonotha macrophylla, Annickia polycarpa, Tieghemella heckelii, and Antrocaryon micraster Extracts
Authors: Dofuor Aboagye Kwarteng , Kumatia Emmanuel Kofi , Chirawurah Jersley Didewurah , Ayertey Frederick
Published: July 2022

Malaria and trypanosomiasis are protozoan diseases which pose a devastating challenge to human health and productivity especially, in Africa where their respective vectors (female Anopheles mosquito and tsetse fly) abound. Various medicinal plants are used to treat these parasitic diseases. However, the scientific basis of their use and toxicological profiles have not been assessed. We have, therefore, evaluated the antiplasmodial, antitrypanosomal, and cytotoxic activities of four African medicinal plant extracts namely, Anthonotha macrophylla leaf (AML), Annickia polycarpa leaf (APLE), Tieghemella heckelii stem bark (THBE), and Antrocaryon micraster stem bark (AMSBE) extracts in vitro against P. falciparum (W2mef laboratory strain), T. brucei (GUTat 3.1 strain), and mammalian RAW 264.7 macrophage cell line, respectively. The most active antiplasmodial extract was AML (IC50 = 5.0 ± 0.08 μg/mL with SI of 21.9). THBE also, produced the most effective antitrypanosomal activity (IC50 = 11.0 ± 0.09 μg/mL and SI of 10.2) among the extracts. In addition, none of the extracts produced toxic effect in the RAW 264.7 macrophage cell line except APLE which was moderately cytotoxic and also produced the least SI in both antitrypanosomal and antiplasmodial assays. These results suggest that AML and THBE could offer safe and alternative therapy for malaria and trypanosomiasis. This is the first study to report the antitrypanosomal and in vitro antiplasmodial activities of these four plants/plant parts. The cytotoxicity of the plant parts used is also being reported for the first time except for the T. heckelii stem bark.
Design of Active Display Stand Combing the Pressure Sensor and Kinematics Algorithm
Authors: Ma Minhai , Yong Lei
Published: July 2022

To solve the trouble of cervical vertebra disease caused by long working hours, this work is aimed at designing an active monitor stand to achieve the best dynamic trajectory planning. The stand operation system consists of image input, face positioning, and robotic arm. According to the user’s face positioning, the inverse kinematics method is used to calculate the steering angle in each direction, and the height and angle are adjusted to make the corresponding selection for the user’s display position on the screen. The C++ is used to program the algorithm, and its core is to control the rotation speed of the motor to ensure that the display screen will not cause any interference to the normal work of the user when the bracket moves. In the inverse operation, the Piper method is used to solve the inverse kinematics issues. After testing, the sliding wedge stroke of the developed active display stand is 0.6 mm, and the height position difference at the reference zero point after the display stand is measured with a digital altimeter is 7.12 mm, which indicates that the stand shows a large deformation after being mounted. This work is of important reference value for realizing the movement of active display stand.
Analysis of Security Operational Characteristics of Distribution Network considering Electric Vehicle Load Access Forecast
Authors: Sun Lei , Ma Yong , Zhu Jinsong , Li Xiaohan , Wu Peng , Bao Xiangyu
Published: July 2022

In recent years, electric vehicles have been widely promoted by virtue of environmental protection and pollution-free advantages. In the future, they are expected to become a mainstream means of transportation. However, as new services and business models become more and more closely related to the distribution network, the traditional AC distribution district has limited ability to respond to the large-scale access of electric vehicles. Therefore, it is becoming increasingly important to improve the ability to respond to electric vehicle access, reduce the negative impact of large-scale electric vehicle access on the grid, and predict and calculate the uncertainty caused by electric vehicle load access. Therefore, this paper proposes the concept of flexible distribution district, constructs the security operational boundary model for flexible distribution district, and uses “security margin percentage” as the measurement mechanism to provide dispatchers with an intuitive system operating status. In addition, this paper also proposes an effective uncertainty quantification method for the problem that it is difficult to measure the changes of bus voltage and line current at network nodes when large-scale electric vehicles are connected to the network. Numerical results demonstrate both the extensibility and the practicality of the proposed security operational boundary. In addition, the proposed uncertainty quantification method can reflect the impact of load changes on the characteristics of the power grid, which is helpful to study the improvement significance of adjusting electric vehicle load changes to distribution network optimization.
Study on the Influence of Initial Water Content on One-Dimensional Freezing Process of the Qinghai-Tibet Silty Clay by Using Digital Image Technology
Authors: Wang Yongtao , Wang Boyuan , Pang Shoude , Hua Weihang , Ji Zhiqiang , Wang Dayan
Published: July 2022

The water content of the foundation soil will change dynamically as a result of rainfall, snowfall, and ground surface evaporation, leading to a significant change in frost heave properties of the foundation soil in cold regions. One-dimensional freezing tests of the Qinghai-Tibet silty clay with three different initial water contents in an open system were carried out using CCD image acquisition technology and computed tomography (CT) scanning technology in combination with the traditional soil freeze-thaw test system. The heat conduct process, cryostructure formation, frost heave development, unfrozen zone consolidation, ice segregation, water migration, and redistribution during soil freezing are studied comprehensively. The results show that increasing the sample’s initial water content will lead to the increase of frozen depth, ladder-like cryostructures in vertical sections, more structural polygons in horizontal sections, and also more obvious ice lens segregation, unfrozen zone consolidation, and water migration during the freezing of soil samples.
Angiographic Predictors of Outcomes After Balloon Test Occlusion
Authors: Mendez Aldo A. , McCarthy David J. , Tonetti Daniel A. , Desai Shashvat M. , Mountz James M. , Gardner Paul A. , Jovin Tudor G. , Jadhav Ashutosh P.
Published: July 2022

Background

Balloon test occlusion (BTO) with adjunctive single‐photon emission computed tomography has been used to predict tolerance after permanent internal carotid artery occlusion. Anatomic characteristics of the cerebral circulation might predict BTO outcomes and identify patients susceptible to test failure.

Methods

We performed a single‐center retrospective analysis of patients who underwent internal carotid artery BTO from July 2013 to June 2020. Patients who passed the clinical BTO underwent single‐photon emission computed tomography imaging; technetium‐99m‐ethyl cysteinate dimer was injected intravenously after 15 to 30 minutes of occlusion and induced hypotension. The diameter of the vessels of the circle of Willis was measured angiographically. Single‐photon emission computed tomography imaging hypoperfusion severity was classified as none, mild, low intermediate, high intermediate, and severe. A threshold vessel diameter with most predicted accuracy for BTO failure was created using the Youden index. The threshold value was tested in a logistic regression for prediction of BTO failure and accuracy as represented with a receiver operator curve.

Results

Fifty‐seven patients underwent BTO. Neoplasia was the most common indication (n=43, 75%). Twelve (21.1%) patients failed the clinical BTO. Contralateral dominant vertebral artery (
P
=0.02), smaller anterior communicating artery (ACom;
P
=0.002), and ipsilateral posterior communicating artery (
P
=0.03) diameters were correlated with clinical BTO failure. Smaller ACom was most predictive with an area under the curve of 0.907. The Youden index identified an ACom diameter threshold of 1.1 mm, with a sensitivity of 91.7% and specificity of 77.8% (odds ratio, 0.026 [95% CI, 0.003–0.226]; receiver operating characteristic, 0.847) for predicting BTO failure. Patients with severe single‐photon emission computed tomography asymmetry had significantly smaller‐caliber ACom arteries (ACom median diameter, 0.95 versus 1.4 mm;
P
=0.0073).

Conclusions

Angiographic findings can be used to predict BTO results. A small ipsilateral posterior communicating artery, and more significantly, a small ACom (<1.1 mm) can be used to identify patients who are likely to fail BTO.
Transition to the Fourth Industrial Revolution: Africa’s Science, Technology and Innovation Framework and Indigenous Knowledge Systems
Authors: Oguamanam Chidi
Published: July 2022

Despite elaborate efforts at Science Technology and Innovation (STI) policy enunciation, Africa has yet to optimally engage with how best to locate and position Indigenous or traditional knowledge (IK/TK) and its stakeholders in the new and emergent technological dynamics often designated as the fourth industrial revolution (4IR) and its bioeconomy components. Given the disconnect over IK/TK systems in African STI policy instruments, the paper argues for a deliberate Indigenous knowledge sensitive continental STI strategy without excluding integral opportunities in other realms such as intellectual property. Such approach to STI is necessary to ensure that Africa is well positioned to leverage and optimise its factor endowments in Indigenous knowledge and underlying systems for its production. Indigenous knowledge is crucial for continental Africa’s participation and ability to benefit from all facets of knowledge production under the 4IR innovation ecosystem. The significance of Indigenous knowledge and its ramification for STI in Africa continues to resonate in the context of the push for equitable access to the benefits of science, technology and innovation especially taking into account the bioeconomy adjunct of the 4IR.