bluuebunny/crossref_metadata_2025 huggingface dataset:
A new Lower Triassic (Induan) Jerus Limestone locality in northwest Pahang, Peninsular Malaysia: Conodont fauna, depositional and tectonic settings
Authors: Metcalfe Ian
Published: April 2016

Limestones exposed north of Raub, Pahang, Malaysia, and sandwiched between the Bentong‐Raub Suture Zone and the westernmost margin of the Sukhothai Arc terrane, yield a late Dienerian (late Induan) conodont fauna. The co‐occurrence of Neospathodus dieneri Sweet (morphotypes 1, 2 and 3) and Neospathodus pakistanensis Sweet represents the Neospathodus dieneri morphotype 3 sub‐zone of the Neospathodus dieneri Zone. The sampled limestones are interpreted as the northwards extension of the Jerus Limestone which crops out near Cheroh and Jerus villages, significantly extending the known outcrop of the Jerus Limestone northwards. The Jerus Limestone is interpreted as hemipelagic and formed in a foredeep or forearc setting on top of the accretionary complex formed by eastwards subduction of the Palaeo‐Tethys during the Lower to Middle Triassic.
Petrogenesis and geodynamic significance of the Ganhe Formation lavas, eastern Great Xing'an Range, China: Evidence from geochemistry and geochronology
Authors: Gu A‐lei , Sun Jing‐gui , Bai Ling‐an , Zhang Yong , Cui Pei‐long , Chai Peng , Zhao Ke‐qiang , Sun Qing‐long , Ren Liang , Chen Yan‐jun , Zhu Jun‐quan
Published: April 2016

Mesozoic volcanic rocks are widespread throughout the Great Xing'an Range of northeastern China. However, there has been limited investigation into the age and petrogenesis of the Mesozoic volcanics in the eastern Great Xing'an Range. According to our research, the volcanic rocks of the Dayangshu Basin, eastern Great Xing'an Range are composed mainly of trachybasalt, basaltic andesite, and basaltic trachyandesite, with minor intermediate–basic pyroclastic rocks. In this study, the geochemistry and geochronology of the Mesozoic volcanic rocks are presented in order to discuss the petrogenesis and tectonic setting of the Ganhe Formation in the Dayangshu Basin. Zircon U–Pb dating by laser ablation inductively coupled plasma–mass spectrometry indicates that the Mesozoic lavas formed during the late Early Cretaceous (114.3–108.8 Ma). This suite of rocks exhibits a range of geochemical signatures indicating subduction‐related genesis, including: (i) calc‐alkaline to high‐K calc‐alkaline major element compositions; (ii) enrichment of large ion lithophile elements (e.g. Rb, Ba, K) and light rare earth elements (LREEs/HREEs =7.33–9.85); and (iii) weak depletion in high field strength elements (e.g. Nb, Ta, Ti). Furthermore, Sr–Nd–Pb isotopic data yield initial 87Sr/86Sr values of 0.70450–0.70463, positive εNd(t) values of +1.8 to +3.3, and a mantle‐derived lead isotope composition. Combined with the regional tectonic evolution, the results of this study suggest that the Ganhe Group lavas are derived from decompression melting of a metasomatized (enriched) lithospheric mantle, related to asthenospheric upwelling, which resulted from lithospheric mantle delamination and produced extension of the continental margin following the subduction of the Paleo‐Pacific Plate.
Post‐ischemic salubrinal treatment results in a neuroprotective role in global cerebral ischemia
Authors: Anuncibay‐Soto Berta , Pérez‐Rodríguez Diego , Santos‐Galdiano María , Font Enrique , Regueiro‐Purriños Marta , Fernández‐López Arsenio
Published: April 2016

This study describes the neuroprotective effect of treatment with salubrinal 1 and 24 h following 15 min of ischemia in a two‐vessel occlusion model of global cerebral ischemia. The purpose of this study was to determine if salubrinal, an enhancer of the unfolded protein response, reduces the neural damage modulating the inflammatory response. The study was performed in CA1 and CA3 hippocampal areas as well as in the cerebral cortex whose different vulnerability to ischemic damage is widely described. Characterization of proteins was made by western blot, immunofluorescence, and ELISA, whereas mRNA levels were measured by Quantitative PCR. The salubrinal treatment decreased the cell demise in CA1 at 7 days as well as the levels of matrix metalloprotease 9 (MMP‐9) in CA1 and cerebral cortex at 48 h and ICAM‐1 and VCAM‐1 cell adhesion molecules. However, increases in tumor necrosis factor α and nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) inflammatory markers were observed at 24 h. Glial fibrillary acidic protein levels were not modified by salubrinal treatment in CA1 and cerebral cortex. We describe a neuroprotective effect of the post‐ischemic treatment with salubrinal, measured as a decrease both in CA1 cell demise and in the blood–brain barrier impairment. We hypothesize that the ability of salubrinal to counteract the CA1 cell demise is because of a reduced ability of this structure to elicit unfolded protein response which would account for its greater ischemic vulnerability. Data of both treated and non‐treated animals suggest that the neurovascular unit present a structure‐dependent response to ischemia and a different course time for CA1/cerebral cortex compared with CA3. Finally, our study reveals a high responsiveness of endothelial cells to salubrinal in contrast to the limited responsiveness of astrocytes.

image

The alleviation of ER stress by enhancing UPR with salubrinal treatment reduces the ischemic damage. This effect varies across the different neurovascular unit cell types. The salubrinal neuroprotective effect on CA1 supports differences in neurovascular unit for different brain regions and involves the inflammatory response and its time course. Thus, UPR modulation could be a therapeutic target in cerebral ischemia.
Water Buffalo (Bubalus bubalis) as a spontaneous animal model of Vitiligo
Authors: Singh Vijay Pal , Motiani Rajender K. , Singh Archana , Malik Garima , Aggarwal Rangoli , Pratap Kunal , Wani Mohan R. , Gokhale Suresh B. , Natarajan Vivek T. , Gokhale Rajesh S.
Published: April 2016

Vitiligo is a multifactorial acquired depigmenting disorder. Recent insights into the molecular mechanisms driving the gradual destruction of melanocytes in vitiligo will likely lead to the discovery of novel therapies, which need to be evaluated in animal models that closely recapitulate the pathogenesis of human vitiligo. In humans, vitiligo is characterized by a spontaneous loss of functional melanocytes from the epidermis, but most animal models of vitiligo are either inducible or genetically programmed. Here, we report that acquired depigmentation in water buffalo recapitulates molecular, histological, immunohistochemical, and ultrastructural changes observed in human vitiligo and hence could be used as a model to study vitiligo pathogenesis and facilitate the discovery and evaluation of therapeutic interventions for vitiligo.
Draft Genome Sequence of
Burkholderia cenocepacia
Strain CEIB S5-2, a Methyl Parathion- and
p
-Nitrophenol-Degrading Bacterium, Isolated from Agricultural Soils in Morelos, Mexico
Authors: Martínez-Ocampo Fernando , Fernández López Maikel Gilberto , Lozano-Aguirre Beltrán Luis Fernando , Popoca-Ursino Elida Carolina , Ortiz-Hernández M. Laura , Sánchez-Salinas Enrique , Ramos Quintana Fernando , Villalobos-López Miguel A. , Dantán-González Edgar
Published: April 2016

Burkholderia cenocepacia
is an opportunistic pathogen that belongs to
Burkholderia cepacia
complex (BCC).
Burkholderia cenocepacia
strain CEIB S5-2 was isolated from agricultural soils in Morelos, Mexico, and previously has shown its abilities for bioremediation. In this study, we report the draft genome sequence of
Burkholderia cenocepacia
strain CEIB S5-2.
Wheezes, crackles and rhonchi: simplifying description of lung sounds increases the agreement on their classification: a study of 12 physicians' classification of lung sounds from video recordings
Authors: Melbye Hasse , Garcia-Marcos Luis , Brand Paul , Everard Mark , Priftis Kostas , Pasterkamp Hans
Published: April 2016

Background

The European Respiratory Society (ERS) lung sounds repository contains 20 audiovisual recordings of children and adults. The present study aimed at determining the interobserver variation in the classification of sounds into detailed and broader categories of crackles and wheezes.

Methods

Recordings from 10 children and 10 adults were classified into 10 predefined sounds by 12 observers, 6 paediatricians and 6 doctors for adult patients. Multirater kappa (Fleiss' κ) was calculated for each of the 10 adventitious sounds and for combined categories of sounds.

Results

The majority of observers agreed on the presence of at least one adventitious sound in 17 cases. Poor to fair agreement (κ<0.40) was usually found for the detailed descriptions of the adventitious sounds, whereas moderate to good agreement was reached for the combined categories of crackles (κ=0.62) and wheezes (κ=0.59). The paediatricians did not reach better agreement on the child cases than the family physicians and specialists in adult medicine.

Conclusions

Descriptions of auscultation findings in broader terms were more reliably shared between observers compared to more detailed descriptions.
When rheumatologists report that they agree with a guideline, does this mean that they practise the guideline in clinical practice? Results of the International Recommendation Implementation Study (IRIS)
Authors: Gvozdenović Emilia , Allaart Cornelia F , van der Heijde Désirée , Ferraccioli Gianfranco , Smolen Josef S , Huizinga Tom W J , Landewé Robert
Published: April 2016

Introduction

The European League Against Rheumatism (EULAR) recommendations for the management of rheumatoid arthritis (RA) and the treat-to-target (T2T) principles have been developed in order to improve the treatment outcome of patients with RA, and have received broad attention. It is not clear, though, whether these recommendations are indeed followed up in clinical practice.

Objective

To investigate if rheumatologists that report to agree with existing guidelines indeed follow them up in clinical practice.

Methods

The International Recommendation Implementation Study (IRIS) included 132 participating rheumatologists from 14 countries. Participating rheumatologists received a questionnaire measuring their awareness/commitment with the EULAR/T2T recommendations and followed a dedicated educational programme. Subsequently, they were asked to enrol 5–10 patients with new-onset RA in the online IRIS database and monitor disease activity and treatment for a period of 1–2 years. Four recommendations (3 from the EULAR recommendations and one from the T2T recommendations) were selected on the basis of testability, and analysed with regard to compliance by participating rheumatologists.

Results

In total, 72 of the 132 participating rheumatologists contributed 378 patients to the database. Of these participants, 70 (98%) agreed upfront with the recommendation that disease-modifying antirheumatic drug (DMARD) therapy should be started as soon as possible after diagnosis in every patient; 69 (96%) of the rheumatologists agreed with the recommendation that methotrexate (MTX) should be part of the first treatment strategy. When measuring the actual performance, it was found that the recommendation on early DMARD start was met in 253 (67%) of the recorded patients, and the recommendation on MTX in 225 (60%) of the recorded patients. Of the participants, 60 (83%) agreed that composite measures should be recorded regularly, but only in 134(54%) of the patients were composite scores actually recorded in ≥50% of patient visits.

Conclusion

Reporting to be compliant with EULAR recommendations and T2T principles, even after dedicated education does not mean they actually comply with it in clinical practice.
A passenger strand variant in miR-196a2 contributes to asthma severity in children and adolescents: A preliminary study
Authors: Hussein Mohammad H. , Toraih Eman A. , Aly Nagwa M. , Riad Eman , Fawzy Manal S.
Published: April 2016

There is emerging evidence to support the role of microRNAs in allergic airway diseases and inflammation. Genetic variants in microRNA genes might affect microRNA-mediated cell regulation. This preliminary study was designed to investigate the association of the microRNA-196a2 rs11614913 (C/T) polymorphism with susceptibility to asthma and clinical outcomes in children and adolescents. Genotyping of rs11614913 polymorphism was determined in 96 patients with bronchial asthma (6–18 years of age) and 96 unrelated controls, using real-time polymerase chain reaction technology. In-silico target prediction and network core analyses were performed. The asthmatics did not show significant differences in genotype distribution (p = 0.609) and allele frequencies (p = 0.428) compared with the controls. There were also no associations with disease duration, age at onset, asthma phenotype, asthma control, therapeutic level, airway hyper-responsiveness, or biochemical parameters in the blood. However, the CC genotype was associated with a more severe degree of asthma (p = 0. 023) and higher frequency of nocturnal asthma (p = 0.002). Carriers for CC were 17 times more likely to develop nocturnal asthma, and had a more than 2.5-fold increased risk for poor disease outcome compared with CT and TT individuals. In conclusion, microRNA-196a2 rs11614913 polymorphism might be associated with asthma severity in our sample of the Egyptian population. Further investigations in studies with a larger sample size and functional tests are needed to validate our findings and to explore the detailed biological mechanisms.
Point-contact Andreev reflection spectroscopy on Bi2Se3 single crystals
Authors: Granstrom C. R. , Fridman I. , Lei H.-C. , Petrovic C. , Wei J. Y. T.
Published: April 2016

To study how Andreev reflection (AR) occurs between a superconductor and a three-dimensional topological insulator (TI), we use superconducting Nb tips to perform point-contact AR spectroscopy at 4.2 K on as-grown single crystals of Bi2Se3. Scanning tunneling spectroscopy and scanning tunneling microscopy are also used to characterize the superconducting tip and both the doping level and surface condition of the TI sample. The point-contact measurements show clear spectral signatures of AR, as well as a depression of zero-bias conductance with decreasing junction impedance. The latter observation can be attributed to interfacial Rashba spin-orbit coupling, and the presence of bulk bands at the Fermi level in our samples suggests that bulk states of Bi2Se3 are involved in the observed AR.
CULTURAL CONTINGENCIES OF OPEN INNOVATION STRATEGIES
Authors: HECKER ACHIM
Published: April 2016

This study draws on a sample of 49,919 firms from 13 countries to investigate the impact of national culture on the performance of inbound open innovation strategies. The study first validates the curvilinear relationships of external search breadth and depth with innovation performance, as first established by Laursen and Salter (2006) [Laursen, K and A Salter (2006). Open for innovation: The role of openness in explaining innovation performance among U.K. manufacturing firms. Strategic Management Journal, 27(2), 131–150] controlling for a number of country-specific factors including culture and the institutional environment. The study then draws on Hofstede’s cultural framework to theoretically and empirically investigate the influence of a country’s culture on the effectiveness of firms’ search strategies. The results show that cultural factors not only directly impact innovation performance, but also interact with search breadth and depth, thereby moderating the success of inbound open innovation strategies.
Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon
Authors: Asghar M. Nadeem , Priyamvada Shubha , Nyström Joel H. , Anbazhagan Arivarasu Natarajan , Dudeja Pradeep K. , Toivola Diana M.
Published: April 2016

Keratins (K) are intermediate filament proteins important in protection from stress. The roles of keratins in the intestine are not clear, but K8 knockout (K8−/−) mice develop a Th2-type colonic inflammation, epithelial hyperproliferation, and mild diarrhea caused by a keratin level-dependent decrease in short-circuit current and net sodium and chloride absorption in the distal colon. The lack of K8 leads to mistargeting or altered levels of membrane proteins in colonocytes; however, the main transporter responsible for the keratin-related ion transport defect is unknown. We here analyzed protein and mRNA levels of candidate ion transporters CFTR, PAT-1, NHE-3, and DRA in ileum, cecum, and proximal and distal colon. Although no differences were observed for CFTR, PAT-1, or NHE-3, DRA mRNA levels were decreased by three- to fourfold and DRA protein was almost entirely lost in K8−/−cecum and proximal and distal colon compared with K8+/+, whereas the levels in ileum were normal. In K8+/−mice, DRA mRNA levels were unaltered, while decreased DRA protein levels were detected in the proximal colon. Immunofluorescence staining confirmed the loss of DRA in K8−/−distal colon, while K8+/−displayed a similar but more patchy apical DRA distribution compared with K8+/+. DRA was similarly decreased when K8 was knocked down in Caco-2 cells, confirming that K8 levels modulate DRA levels in an inflammation-independent manner. Taken together, the loss of DRA in the K8−/−mouse colon and cecum explains the dramatic chloride transport defect and diarrheal phenotype after K8 inactivation and identifies K8 as a novel regulator of DRA.
Primeras conversaciones sobre estudios organizacionales en Chile: LAEMOS 2016
Authors: Mandiola Marcela
Published: April 2016

La Conferencia LAEMOS, Latin American and European Meeting in Organization Studies, se ha orientado a promover y difundir la investigación académica en el campo de los estudios organizacionales desarrollada primordialmente en América Latina y Europa. Su principal contribución ha sido el incentivar el trabajo interdisciplinario en el estudio de lo organizacional que vincule el nivel más micro del análisis de casos, con el nivel más amplio de lo institucional y las fuerzas globales que dan cuenta de sus procesos y estructuras, considerando siempre los enfoques históricos y contextuales que les dan sentido
In vivo Raman Microspectroscopy: Intra- and Intersubject Variability of Stratum Corneum Spectral Markers
Authors: Quatela Alessia , Miloudi Lynda , Tfayli Ali , Baillet-Guffroy Arlette
Published: April 2016

Background: In vivo Raman spectroscopy is a powerful tool for real-time analysis and in situ evaluation of tissues such as the skin. The efficiency of this technique has been widely demonstrated as a label-free method for in vivo evaluation of the skin. The aim of this study is to gather information about inter- and intra-individual variations in the spectral descriptors of water content and structure, organization of the lipid barrier and structure of proteins in the stratum corneum (SC). Methods: In vivo SC measurements were performed on 17 female volunteers aged 20-30 years (phototypes I and II). For intra-individual variability, spectral collection was performed on 5 successive days per volunteer. Shapiro-Wilk and Cochran tests were applied to check the normality and the homoscedasticity of variances. ANOVA was then applied to evaluate intra- and intergroup variability. Results: ANOVA was performed on the spectral descriptors of water content and structure, organization of the lipid barrier and secondary structure of proteins in the SC. No significant intra- and interday variability was observed for all volunteers. Despite the low value of the total relative standard deviation, a highly significant variation was observed between volunteers. Conclusion: Interindividual variability for Raman measurements is significant for a set of volunteers with normal nondiseased SC and close phototypes. This variability should be taken into consideration as a threshold for significant variance when working in vivo.
Prescription Rates of Cardiovascular Medications in a Large UK Primary Care Chronic Kidney Disease Cohort
Authors: Major Rupert , Shepherd David , Warwick Graham , Brunskill Nigel
Published: April 2016

Background and Aims: Chronic kidney disease (CKD) is associated with increased cardiovascular (CV) risk. Guidelines have suggested the universal use of statins in CKD but aspirin's role is less well defined. The aim of this study was to determine prescription rates for statins and aspirin in a UK-based CKD cohort and to establish factors that influenced prescription rates. Methods: We used data from a UK primary care CKD cohort to study rates of prescription of statins and aspirin. Simple rates were initially calculated. Binary logistic regression was utilized with either statin or aspirin prescription as the outcome variable and covariates including demographic details and comorbidities. Results: There were 31,056 individuals in the cohort with at least one estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73 m2, and 65.1% individuals had 2 eGFR results <60 ml/min/1.73 m2 more than 3 months apart. Mean eGFR at baseline was 51.1 ml/min/1.73 m2 (SD 9.1), and 64.9% had a diagnosis of hypertension (HTN), 18.8% had diabetes mellitus (DM) and 29.8% a history of CV disease. Statins were prescribed to 14,972 (48.2%) and aspirin to 11,023 (35.5%). The regression model suggested that CV disease, HTN and DM influenced the prescriptions of statins and aspirin but overall CKD stage, calculated by either eGFR or proteinuria, did not. Conclusions: Prescriptions of statins and aspirin in CKD is based more on the presence of comorbidities than the CKD severity. Further physician and patient education of the increased CV risk associated with CKD and its suitability for CV medication intervention is required.
Patch Grafting Using a Cryopreserved Descemet Stripping Automated Endothelial Keratoplasty Flap for Treating Corneal Perforation
Authors: Okada Arisa , Sano Ichiya , Ikeda Yoshifumi , Fujihara Etsuko , Tanito Masaki
Published: April 2016

A 73-year-old woman with a corneal perforation of undetermined etiology was treated with corneal patch grafting. A residual partial-thickness corneal button obtained during a previous Descemet stripping automated endothelial keratoplasty (DSAEK) surgery and stored at –80°C in Optisol GS for 3 months was used as a patch graft. Five days postoperatively, the anterior chamber was reformed and the perforation was masked by the donor cornea. During the next several weeks, gradual displacement of the anterior edge of the donor cornea in the limbal direction occurred. Seven weeks postoperatively, further displacement of the donor cornea resulted in unmasking of the perforated area. At this time, the corneal defect was closed by stromal scar tissue and corneal epithelium. Five months postoperatively, best corrected visual acuity was 1.0 without marked astigmatism and intraocular pressure was 9 mm Hg in the left eye. From this case, we learned that cryopreserved DSAEK flaps stored longer than reported previously can be used as patch grafts to treat emergency conditions. Scar tissue can fill a corneal stromal defect 1 mm in diameter during temporary patch grafting for less than 2 months.
Use of Volume Rendered, Maximum Intensity Projection Images to Assess Whether the Medial Calyx Synonymous with the Posterior Calyx
Authors: Pradeepa M.G. , Sinha Maneesh , Krishnamoorthy Venkatesh
Published: April 2016

Introduction: This paper attempts to verify the anatomical veracity of the belief that in order to enter into a posterior calyx one must aim for the medial calyx during a percutaneous nephrolithotomy (PCNL). Methods: Volume rendered and maximum intensity projection reconstructions of normal pelvicalyceal systems were assessed in various rotational planes. An experienced urologist decided the appropriate access for PCNL in the upper, interpole and lower calyx on each side. The selected calyx was then viewed on anteroposterior sections to decide whether they were projecting laterally or medially. Results: Of the 508 calyces studied, the posterior calyx was projecting laterally in 72% and medially in 28%. In the upper calyx, the posterior calyx was projecting laterally in a majority of cases, 94% on the right and 89% on the left. In the right lower calyx, the posterior calyx was pointing laterally in 86%, whereas the distribution on the left was 64%. Conclusion: Our results refute the belief that the medial calyx is always synonymous with the lateral calyx.
A Case of Sustained Intraocular Pressure Elevation after Multiple Intravitreal Injection of Ranibizumab and Aflibercept for Neovascular Age-Related Macular Degeneration
Authors: Matsubara Hisashi , Miyata Ryohei , Kobayashi Maki , Tsukitome Hideyuki , Ikesugi Kengo , Kondo Mineo
Published: April 2016

Intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents are widely used to treat neovascular age-related macular degeneration (nAMD). Although these treatments are effective, multiple injections have recently been recommended to ensure that there is a good long-term prognosis. However, sustained intraocular pressure (IOP) elevations have been reported to develop after multiple injections of anti-VEGF agents. We present our findings of a case of uncontrolled and persistent IOP elevation after switching from intravitreal ranibizumab injections to intravitreal aflibercept injections. A 74-year-old Japanese man without a history of glaucoma underwent 22 ranibizumab injections for nAMD and suddenly developed an elevated IOP after the 22nd injection. Although the subsequent medical treatment led to normalization of his IOP, the subretinal fluid under the central fovea remained even after the 25th injection of ranibizumab. Thus, ranibizumab treatment was switched to bimonthly intravitreal aflibercept injections in conjunction with glaucoma medications. His IOP recovered to within the normal range; however, after the 11th aflibercept injection, there was a sudden elevation of his IOP in spite of the continued glaucoma medications. Due to this sustained IOP elevation, his aflibercept injections were suspended for 16 weeks. Because his IOP could not be normalized by a full glaucoma medication regimen, the patient underwent trabeculotomy, which resulted in a lowering of the IOP to normal levels. We conclude that patients who receive serial intravitreal injections of anti-VEGF agents need to be closely monitored because severe and sustained ocular hypertension can develop.
Laparoscopic Nephron Sparing Surgery Assisted with Laparoscopic Ultrasonography on Centrally Located Renal Tumor - Single Center Experience
Authors: Dong Dexin , Ji Zhigang , Li Hanzhong , Yan Weigang , Zhang Yushi
Published: April 2016

Objective: To investigate the clinical value of laparoscopic nephron sparing surgery (LNSS) assisted with laparoscopic ultrasonography (LUS) on centrally located renal tumors. Materials and Methods: Clinical data of 19 patients who underwent LNSS on centrally located renal tumors assisted with LUS were retrospectively analyzed. LUS was used to confirm the location, size, blood supply, and boundary of renal tumors, and to confirm that the tumor was removed completely with negative margin. Results: The 19 centrally located renal tumors were deep in renal parenchyma without obvious convex. Eleven cases were in the middle of the kidney, 3 cases were in the upper pole, and 5 cases were in the inferior pole. The tumor size was in the range 1.0-3.9 cm, with an average of 2.46 cm. The pathological results were 13 cases of renal clear cell carcinoma, 1 case of reninoma, 1 case of renal cyst, and 3 cases of angioleiomyolipoma. The surgical margins were negative in all 19 cases. Conclusions: LUS has a high clinical value in LNNS on centrally located renal tumors and it helps to determine the location of centrally located tumors and guarantee negative margins.
Plural: atuação dinâmica e transversal do gestor cultural
Authors: Ribeiro Ludmila Ferreira
Published: April 2016

O presente artigo tem como proposta refletir sobre o processo de profissionalização do campo da cultura, considerando a importância da área para o desenvolvimento sustentável e a necessidade de reunir na prática técnicas e conhecimentos transversais que favoreçam a dinâmica de atuação dos profissionais na cadeia produtiva da cultura. Tendo como base a produção contemporânea especificamente sobre a organização da cultura, gestão e produção e a formação dos profissionais da área, são apresentados desafios e responsabilidades do gestor cultural em contexto de globalização, diversidade cultural e estruturação de políticas públicas para a cultura.
Cartas ex-votivas: histórias de vidas, memórias social e comunicação
Authors: Oliveira José Cláudio Alves de
Published: April 2016

O intuito do artigo é analisar alguns aspectos dos bilhetes e cartas ex-votivos, encontrados em salas de milagres dos santuários do Brasil e México. O trabalho parte de dados coletados no Projetos Ex-votos do Brasil e Ex-votos das Américas, em andamento, que objetiva identificar, catalogar e iconografar a rica tipologia dos ex-votos no Brasil e Américas. Aqui, o recorte tem por objetivo falar das cartas e bilhetes ex-votivos como fontes para a informação e a memória social, por serem ricas fontes para o estudo da história local, regional e nacional. No curso do texto alguns exemplos que ilustrarão o potencial desse documento, media ou simplesmente testemunho social. Como base, estão autores dos campos da memória, como Bérgson e Jacques Le Goff, da comunicação, a exemplo de Luiz Beltrão e José Marques de Melo, e da Museologia, a pesquisadora Maria Augusta da Silva. Orlandi, traz uma base para a argumentação sobre a análise do discurso, que faz parte das narrativas dos denominados “ex-votos bibliográficos”. Busca-se situar algumas questões relativas à gramática da escrita e aos suportes, que trazem características marcantes de uma rica tradição latina de longa duração, que almeja a relação entre o crente e o ente superior.
WWE: Um Universo de Lutas que Invadiu o Brasil
Authors: Amaral Carlos Cézar Domingos do , Chiarioni Bruno
Published: April 2016

A WWE, World Wrestling Entertainment é um show de lutas ligadas ao entretenimento. A empresa foi fundada nos EUA na decáda de 1950. No início o respectivo nome era bem distinto do atual. A empresa era denominada por NWA Capitol Wrestling. O grande salto da empresa acontece em 1997, com a WWFATTITUDE, a epóca mais lembrada e criticada da companhia, pois é até hoje lembrada com grandes combates e lutadores que depois foram para o cinema como Hulk Hogan e The Rock, mas também pelas bebidas alcoolicas e depredamento dos bons costumes americanos. Em 2002, o nome definitivo é criado e assim nasce a WWE, mas o intuito das lutas continuava, mas bem diferente da Era da Atitude da WWF. As lutas da WWE estão enquadradas no estilo pro-wrestling que no Brasil é conhecida como Luta Livre Catch. Então esse estudo pretende mostrar um pouco do histórico da empresa, a vontade em crescer no Brasil, pesquisa bibliografica sobre o tema e entrevistas com fãs sobre a transmissão da WWE em nosso país, respostas sobre o porque da tradução dos golpes e como fazer sucesso em território dominado pelo futebol.
O Lugar da televisão é no Museu?
Authors: Andreoni Renata , Borges Márcia , Gomes Victor Márcio Laus Reis
Published: April 2016

Este trabalho busca possíveis relações entre a televisão e o museu, através de uma abordagem de convergência transmidiática. A reflexão é construída sobre uma narrativa ficcional televisiva, a telenovela.
A Opinião do Leitor: o Discurso do Sujeito Coletivo no jornal Diário Catarinense
Authors: Golembiewski Carlos
Published: April 2016

Este artigo analisa a opinião do leitor sobre as Políticas Públicas existentes no país e em Santa Catarina. A análise ocorreu no material publicado durante 10 dias do mês de setembro na coluna Diário do Leitor do jornal Diário Catarinense. Utilizamos como referencial teórico as seguintes noções: Carta (Melo, 1995), Estado (Bauman, 2013), Leitor (Wolton, 2009), Mídia (Maffesoli,2003) e Políticas Públicas (Secchi, 2012). Como método usamos os preceitos do Discurso do Sujeito Coletivo propostos por Lefévre & Lefévre (2003). Sobre as conclusões, percebe-se um leitor atento e preocupado com os problemas nacionais e com a sua vida cotidiana nos municípios. Os temas mais recorrentes foram: a Política, a Infraestrutura das cidades e a Segurança Pública.
O grotesco na era virtual: Navegando na Web com o barqueiro da morte
Authors: R. Santos Darlan
Published: April 2016

Em A divina comédia, de Dante Alighieri, Flégias é o barqueiro, responsável por fazer a travessia das almas no inferno, pelo rio Estige. Gil Vicente, em sua “trilogia das barcas”, também evoca o soturno comandante, responsável pela navegação derradeira. Atualmente, o vocábulo “navegar” adquire nova acepção, referindo-se ao acesso à Internet. Neste sentido, pretende-se desenvolver a metáfora do barqueiro da morte que conduz a navegação virtual, em nossos dias, ao investigarmos a fetichização dos crimes, das aberrações e do insólito, na Web, relacionando-a, em linhas gerais, ao grotesco.
A Miramax no campo da indústria cinematográfica norte-americana: Uma análise das disputas pela consagração e pelas bilheterias na temporada de premiações de 1998
Authors: Félix André , Brito Karina , Teixeira Wanderley
Published: April 2016

A construção da noção de campo da produção de bens simbólicos por Pierre Bourdieu, ao longo de sua trajetória, parte do princípio de que ele é um espaço de oposições e disputas internas protagonizadas por seus agentes. Ao mesmo tempo, esses integrantes do campo estabelecem relações de recusas e aderências ao modus operandi de outros campos, especialmente o campo econômico que apresenta-se, em muitos casos, como dominante na relação com os demais, todos inseridos no mesmo espaço social.
Association of falls, fear of falling, handgrip strength and gait speed with frailty levels in the community elderly
Authors: Silveira Tatiana , Pegorari Maycon S. , Castro Shamyr S. de , Ruas Gualberto , Novais-Shimano Suraya G. , Patrizzi Lislei J.
Published: April 2016

Introduction: The Frailty Syndrome is not synonymous with disability, but may be a precursor of etiological and physiological dysfunction, which affects mobility before causing reduced functional capacity, explaining conditions of weakness, weight loss, and abnormal gait. Study design: This is an analytical, observational, cross-sectional study. Objective: To verify the association of handgrip strength, gait speed, fear of falling, and falls with the level of frailty. Methods: Study consisting of 54 participants, aged 65 and older, enrolled in a health care and monitoring government program in the municipality of Uberaba, Minas Gerais, Brazil. The volunteers were assessed for frailty, – non-frail group (NG), pre-frail group (PG), and frail group (FG) – according to the Fried criteria, and based on the outcomes of handgrip strength, gait speed, fear of falling, and falls. An inferential descriptive statistical analysis followed, with Chi-square and KruskallWallis tests performed by the Stata11.0 software. Results: In the comparative analysis between the groups studied there was statistical significance relative to handgrip strength (FG and NG), gait speed (NG and FG / NG and PG), and fear of falling (NG and FG). There was no significant difference between the levels of frailty and falls. Conclusions: Frailty is associated with reduced muscle strength, decreased gait speed, and greater fear of falling in elderly people of the community
A questão do popular na música da Amazônia paraense da primeira metade do século XX
Authors: Costa Antonio Maurício Dias da
Published: April 2016

O presente estudo aborda a ativi­dade musical de artistas paraenses da primei­ra metade do século XX, centrado na reflexão sobre os sentidos de “popular” ensejados na repercussão da atuação intelectual e artística desses sujeitos. As pistas investigadas no tra­balho foram coletadas em periódicos, regis­tros memorialísticos e ensaios de folcloristas, dentro do recorte cronológico selecionado. Os dados indicam a conformação de dois campos de atuação musical nesse período, em que se inseriram músicos-folcloristas e músicos po­pulares profissionais. O texto analisa a invoca­ção de diferentes sentidos nas criações destes músicos, no contexto amazônico, em torno de classificações como música folclórica, música popular e música artística.
Micro–RNA-126 Reduces the Blood Thrombogenicity in Diabetes Mellitus via Targeting of Tissue Factor
Authors: Witkowski Marco , Weithauser Alice , Tabaraie Termeh , Steffens Daniel , Kränkel Nicolle , Witkowski Mario , Stratmann Bernd , Tschoepe Diethelm , Landmesser Ulf , Rauch-Kroehnert Ursula
Published: April 2016

Objective—

Diabetes mellitus involves vascular inflammatory processes and is a main contributor to cardiovascular mortality. Notably, heightened levels of circulating tissue factor (TF) account for the increased thrombogenicity and put those patients at risk for thromboembolic events. Here, we sought to investigate the role of micro-RNA (miR)–driven TF expression and thrombogenicity in diabetes mellitus.

Approach and Results—

Plasma samples of patients with diabetes mellitus were analyzed for TF protein and activity as well as miR-126 expression before and after optimization of the antidiabetic treatment. We found low miR-126 levels to be associated with markedly increased TF protein and TF-mediated thrombogenicity. Reduced miR-126 expression was accompanied by increased vascular inflammation as evident from the levels of vascular adhesion molecule-1 and fibrinogen, as well as leukocyte counts. With optimization of the antidiabetic treatment miR-126 levels increased and thrombogenicity was reduced. Using a luciferase reporter system, we demonstrated miR-126 to directly bind to the
F3
-3′-untranslated region, thereby reducing TF expression both on mRNA and on protein levels in human microvascular endothelial cells as well as TF mRNA and activity in monocytes.

Conclusions—

Circulating miR-126 exhibits antithrombotic properties via regulating post-transcriptional TF expression, thereby impacting the hemostatic balance of the vasculature in diabetes mellitus.
Systematics of small Gehyra (Squamata: Gekkonidae) of the southern Kimberley, Western Australia: redescription of G. kimberleyi Börner & Schüttler, 1983 and description of a new restricted range species
Authors: OLIVER PAUL M. , BOURKE GAYLEEN , PRATT RENAE C. , DOUGHTY PAUL , MORITZ CRAIG
Published: April 2016

Ongoing fieldwork and molecular research continues to reveal that the monsoonal tropics of northern Australia contain more vertebrate species than currently recognised. Here we focus on two morphologically distinctive, yet unrecognised forms in the genus Gehyra from the southern Kimberley region and surrounding deserts. We base our descriptions on a combination of unpublished genetic data and a morphological examination of voucher specimens. We recognise and redescribe G. kimberleyi, a species with a broad distribution extending over most of the south-west Kimberley, across the Great Sandy Desert and into the far northern Pilbara. This species has been previously assigned to G. pilbara owing to its frequent occurrence on termite mounds and short snout, but can be distinguished from G. pilbara and other regionally sympatric Gehyra by its moderate body size, moderate number of pre-cloacal pores in males (12–17) and aspects of dorsal colouration. We also describe G. girloorloo sp. nov., a small rock-dwelling species with a short snout, low number of pre-cloacal pores in males (8–11) and pinkish-grey dorsal colouration with alternating series of indistinct pale spots and irregular transversely-aligned dark blotches. The new species appears to be restricted to a relatively small region of exposed limestone karst in the south-west Kimberley and is entirely circumscribed by morphologically similar congeners.
First record of the tribe Phlepsiini (Hemiptera: Cicadellidae: Deltocephalinae) from China, with description a new genus and species
Authors: DAI REN-HUAI , QU LING , YANG MAO-FA
Published: April 2016

The tribe Phlepsiini Zahniser & Dietrich, 2013 is reported from China for the first time based on a new genus and species, Brevivalvala melanosticta gen. et sp. nov., here described and illustrated from Yunnan Province. This new genus can be distinguished from other genera in this tribe by the short valve and subgenital plate without macrosetae.
Sensitivity of Tornado Dynamics to Soil Debris Loading
Authors: Bodine David J. , Maruyama Takashi , Palmer Robert D. , Fulton Caleb J. , Bluestein Howard B. , Lewellen David C.
Published: April 2016

Past numerical simulation studies found that debris loading from sand-sized particles may substantially affect tornado dynamics, causing reductions in near-surface wind speeds up to 50%. To further examine debris loading effects, simulations are performed using a large-eddy simulation model with a two-way drag force coupling between air and sand. Simulations encompass a large range of surface debris fluxes that cause negligible to substantial impact on tornado dynamics for a high-swirl tornado vortex simulation.

Simulations are considered for a specific case with a single vortex flow type (swirl ratio, intensity, and translation velocity) and a fixed set of debris and aerodynamic parameters. Thus, it is stressed that these findings apply to the specific flow and debris parameters herein and would likely vary for different flows or debris parameters. For this specific case, initial surface debris fluxes are varied over a factor of 16 384, and debris cloud mass varies by only 42% of this range because a negative feedback reduces near-surface horizontal velocities. Debris loading effects on the axisymmetric mean flow are evident when maximum debris loading exceeds 0.1 kg kg−1, but instantaneous maximum wind speed and TKE exhibit small changes at smaller debris loadings (greater than 0.01 kg kg−1). Initially, wind speeds are reduced in a shallow, near-surface layer, but the magnitude and depth of these changes increases with higher debris loading. At high debris loading, near-surface horizontal wind speeds are reduced by 30%–60% in the lowest 10 m AGL. In moderate and high debris loading scenarios, the number and intensity of subvortices also decrease close to the surface.
Reconstructed Regional Mean Climate with Bayesian Model Averaging: A Case Study for Temperature Reconstruction in the Yunnan–Guizhou Plateau, China
Authors: Zhang Xianliang , Yan Xiaodong , Chen Zhenju
Published: April 2016

A method was developed, based on Bayesian model averaging (BMA), to reconstruct regional mean temperature. Different from the arithmetic mean, which gives equal weight to each chronology, BMA weights the chronologies according to their contributions to the actual temperature variances. Thus, BMA holds advantages in integrating chronologies to reconstruct the regional mean temperature. The regional mean temperature for the Yunnan–Guizhou Plateau was reconstructed for the past four centuries (1628–2005) using BMA, which performed better than the simple arithmetic mean. The reconstruction explained 41.33% of total observed temperature variances during the period of 1961–2005. The warmest decade was found to be 1840–50 and the coldest 1810–20 prior to the instrumental period. The reconstructed temperature showed a high correlation (r > 0.7, p < 0.001) with gridded observed temperatures in most grid cells of the Yunnan–Guizhou Plateau, suggesting that the regional temperature changes were captured well by the reconstruction.
An Evaluation of Snow Initializations in NCEP Global and Regional Forecasting Models
Authors: Dawson Nicholas , Broxton Patrick , Zeng Xubin , Leuthold Michael , Barlage Michael , Holbrook Pat
Published: April 2016

Snow plays a major role in land–atmosphere interactions, but strong spatial heterogeneity in snow depth (SD) and snow water equivalent (SWE) makes it challenging to evaluate gridded snow quantities using in situ measurements. First, a new method is developed to upscale point measurements into gridded datasets that is superior to other tested methods. It is then utilized to generate daily SD and SWE datasets for water years 2012–14 using measurements from two networks (COOP and SNOTEL) in the United States. These datasets are used to evaluate daily SD and SWE initializations in NCEP global forecasting models (GFS and CFSv2, both on 0.5° × 0.5° grids) and regional models (NAM on 12 km × 12 km grids and RAP on 13 km × 13 km grids) across eight 2° × 2° boxes. Initialized SD from three models (GFS, CFSv2, and NAM) that utilize Air Force Weather Agency (AFWA) SD data for initialization is 77% below the area-averaged values, on average. RAP initializations, which cycle snow instead of using the AFWA SD, underestimate SD to a lesser degree. Compared with SD errors, SWE errors from GFS, CFSv2, and NAM are larger because of the application of unrealistically low and globally constant snow densities. Furthermore, the widely used daily gridded SD data produced by the Canadian Meteorological Centre (CMC) are also found to underestimate SD (similar to GFS, CFSv2, and NAM), but are worse than RAP. These results suggest an urgent need to improve SD and SWE initializations in these operational models.
A Simple Model of the Ice Shelf–Ocean Boundary Layer and Current
Authors: Jenkins Adrian
Published: April 2016

Ocean-forced basal melting has been implicated in the widespread thinning of Antarctic ice shelves, but an understanding of what determines melt rates is hampered by limited knowledge of the buoyancy- and frictionally controlled flows along the ice shelf base that regulate heat transfer from ocean to ice. In an attempt to address this deficiency, a simple model of a buoyant boundary flow, considering only the spatial dimension perpendicular to the boundary, is presented. Results indicate that two possible flow regimes exist: a weakly stratified, geostrophic cross-slope current with upslope flow within a buoyant Ekman layer or a strongly stratified, upslope current with a weak cross-slope flow. The latter regime, which is analogous to the steady solution for a katabatic wind, is most appropriate when the ice–ocean interface is steep. For the gentle slopes typical of Antarctic ice shelves, the buoyant Ekman regime, which has similarities with the case of an unstratified density current on a slope, provides some useful insight. When combined with a background flow, a range of possible near-ice current profiles emerge as a result of arrest or enhancement of the upslope Ekman transport. A simple expression for the upslope transport can be formed that is analogous to that for the wind-forced surface Ekman layer, with curvature of the ice shelf base replacing the wind stress curl in driving exchange between the Ekman layer and the geostrophic current below.