bluuebunny/crossref_metadata_2025 huggingface dataset:
Brief Research Report: A Pilot Study of Cognitive Behavioral Regulation Therapy (CBT-REG) for Young People at High Risk of Early Transition to Bipolar Disorders
Authors: Scott Jan , Meyer Thomas D.
Published: January 2021

Attempts to increase early identification of individuals in the early stages of bipolar disorders (i.e., individuals at high risk of bipolar disorders and/or experiencing a subthreshold syndrome with bipolar symptoms) have highlighted the need to develop high benefit-low risk interventions. We suggest that any new psychological therapy should (i) be acceptable to young people seeking help for the first time, (ii) be applicable to “at risk” conditions and sub-syndromal states and (iii) consider pluripotent factors that may be linked to illness progression not only for bipolar disorders specifically but also for other potential disease trajectories. However, evidence indicates that current interventions for youth with emerging mood disorders mainly represent approaches abbreviated from “disorder-specific” therapies used with older adults and are primarily offered to first episode cases of bipolar disorders who are also receiving psychotropic medication. This brief report discusses empirical findings used to construct core targets for therapeutic interventions that might reduce or delay transition to full-threshold bipolar disorders. We describe an intervention that includes strategies for problem-solving, reducing sleep-wake cycle disturbances, self-management of rumination and that addresses the needs of individuals with “sub-threshold” presentations who are probably at risk of developing a bipolar or other major mental disorders. Outcome data from a case series of 14 youth indicates that the intervention appears to demonstrate a relatively high benefit-to-risk ratio, promising levels of engagement with the therapy modules, and the therapy appears to be acceptable to a wide range of help-seeking youth with early expressions of bipolar psychopathology.
Adaptive Time-Dependent Priors and Bayesian Inference to Evaluate SARS-CoV-2 Public Health Measures Validated on 31 Countries
Authors: Turbé Hugues , Bjelogrlic Mina , Robert Arnaud , Gaudet-Blavignac Christophe , Goldman Jean-Philippe , Lovis Christian
Published: January 2021

With the rapid spread of the SARS-CoV-2 virus since the end of 2019, public health confinement measures to contain the propagation of the pandemic have been implemented. Our method to estimate the reproduction number using Bayesian inference with time-dependent priors enhances previous approaches by considering a dynamic prior continuously updated as restrictive measures and comportments within the society evolve. In addition, to allow direct comparison between reproduction number and introduction of public health measures in a specific country, the infection dates are inferred from daily confirmed cases and confirmed death. The evolution of this reproduction number in combination with the stringency index is analyzed on 31 European countries. We show that most countries required tough state interventions with a stringency index equal to 79.6 out of 100 to reduce their reproduction number below one and control the progression of the pandemic. In addition, we show a direct correlation between the time taken to introduce restrictive measures and the time required to contain the spread of the pandemic with a median time of 8 days. This analysis is validated by comparing the excess deaths and the time taken to implement restrictive measures. Our analysis reinforces the importance of having a fast response with a coherent and comprehensive set of confinement measures to control the pandemic. Only restrictions or combinations of those have shown to effectively control the pandemic.
Epidemic Prevention During Work Resumption: A Case Study of One Chinese Company's Experience
Authors: Zhang Quan , Wu Yijin , Li Meiyu , Li Linzi
Published: January 2021

Background: The COVID-19 epidemic not only brings challenges to the health of people all over the world, but also impacts the global economy, and employment. Therefore, promoting industry and business to resume work safely has become an important step to be taken by all countries in overcoming the economic recession and restarting growth.

Objective: This study aims to elaborate on epidemic prevention measures a Chinese company (Company C) took during work resumption.

Methods: In this study, we used a case study design, with field research method applied to data collection and analysis.

Results: It has been identified that Company C took a range of measures to prevent the outbreak of COVID-19 inside the company, which involve work resumption preparation (information survey, health training, work resumption plan, epidemic prevention plan), facilities management, materials management, employee activity management, and so on.

Conclusion: When the COVID-19 epidemic was initially controlled in February, the Chinese government allowed enterprises to resume work voluntarily, which did not bring about a rebound in the epidemic. One important reason is that Chinese enterprises have taken multiple measures to prevent the spread of the COVID-19 virus. Company C's practices could shed some light on how companies in Western countries resume their work during the COVID-19 pandemic.
Seven Challenges for Communication in Modern Railway Systems
Authors: Yaacoub Elias , Alsharoa Ahmad , Ghazzai Hakim , Alouini Mohamed-Slim
Published: January 2021

To meet the increasing demands for passenger data rates, modern railway communication networks face significant challenges. The advent of 5G communications after the long-term evolution (LTE) and LTE-Advanced (LTE-A) systems provides several technological advances to address these challenges. In this paper, after reviewing the main 5G communication aspects for modern railways, we describe seven main challenges faced by train connectivity, and discuss appropriate solutions. Specifically, we elaborate on techniques for ensuring connectivity and energy efficiency for the passengers' user equipment (UE) through the use of mobile relays (MRs) on top of the train wagons in conjunction with intelligent resource allocation.
Comparative Analysis of the Bibliographic Data Sources Dimensions and Scopus: An Approach at the Country and Institutional Levels
Authors: Guerrero-Bote Vicente P. , Chinchilla-Rodríguez Zaida , Mendoza Abraham , de Moya-Anegón Félix
Published: January 2021

This paper presents a large-scale document-level comparison of two major bibliographic data sources: Scopus and Dimensions. The focus is on the differences in their coverage of documents at two levels of aggregation: by country and by institution. The main goal is to analyze whether Dimensions offers as good new opportunities for bibliometric analysis at the country and institutional levels as it does at the global level. Differences in the completeness and accuracy of citation links are also studied. The results allow a profile of Dimensions to be drawn in terms of its coverage by country and institution. Dimensions’ coverage is more than 25% greater than Scopus which is consistent with previous studies. However, the main finding of this study is the lack of affiliation data in a large fraction of Dimensions documents. We found that close to half of all documents in Dimensions are not associated with any country of affiliation while the proportion of documents without this data in Scopus is much lower. This situation mainly affects the possibilities that Dimensions can offer as instruments for carrying out bibliometric analyses at the country and institutional level. Both of these aspects are highly pragmatic considerations for information retrieval and the design of policies for the use of scientific databases in research evaluation.
The Relationship among Family Business, Corporate Governance, and Firm Performance: An Empirical Assessment in the Tourism Sector
Authors: Leopizzi Rossella , Pizzi Simone , D'Addario Fabrizio
Published: January 2021

Tourism has been the subject of great attention of policy makers. The centrality of the sector derives from multiple factors, including the high number of subjects employed within the supply chain, the contribution to developing nations’ economic growth, and the environmental implications of establishing new productive activities. Under this scenario, family holdings play a central role as the main types of organisations active in the sector. In this sense, an understanding of these companies’ financial performance cannot disregard the understanding of the governance mechanisms that characterize the same given the potential divergence between “family” and “business” objectives. The research aims to encourage the development of new empirical evidence about this business model, providing specific contributions regarding the role of family members in companies’ decision-making mechanisms. For our purposes, an empirical analysis based on the evaluation of 343 Italian hotels was built.
Selection and Micropropagation of an Elite Melatonin Rich Tulsi (Ocimum sanctum L.) Germplasm Line
Authors: Shukla Mukund R. , Kibler Annaliese , Turi Christina E. , Erland Lauren A. E. , Sullivan J. Alan , Murch Susan J. , Saxena Praveen K.
Published: January 2021

Tulsi (Ocimum sanctum L.) is a sacred plant of medicinal and spiritual significance in many cultures. Medicinal properties of Tulsi are ascribed to its phytochemicals with antioxidant capabilities. The current study was undertaken to screen a large seed population of Tulsi to select germplasm lines with high antioxidant potential and to standardize protocols for micropropagation and biomass production to produce a phytochemically consistent crop. A total of 80 germplasm lines were established under in vitro conditions and screened for their antioxidant potential determined with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) bioassay. The micropropagation of a selected line, named Vrinda, was established using nodal cultures grown on Murashige and Skoog medium containing benzylaminopurine (1.1 µM), gibberellic acid (0.3 µM), and activated charcoal (0.6%). The antioxidant phytohormones melatonin and serotonin were quantified in the field and greenhouse grown tissues of Vrinda and melatonin levels were found to be consistent in both conditions with higher serotonin levels under field conditions. This integrated approach combining the in vitro selection and propagation offers potential applications in the development of safe, effective, and novel natural health products of Tulsi, and many other medicinal plant species.
The Impact of Skinsuit Zigzag Tape Turbulators on Speed Skating Performance
Authors: Timmer Nando , Veldhuis Leo
Published: January 2021

At the 1998 Nagano Winter Olympic Games, zigzag tape was introduced on the race suit lower legs and cap of speed skaters. Application of these zigzag devices on live skaters and cylinders in the wind tunnel showed large improvements in the aerodynamic drag. These wind-tunnel results were unfortunately not widely published, and the impact of the zigzag strips in a real skating environment was never established. This paper aims to show the background of the application of the zigzag tape and to establish the impact it may have had on speed-skating performance. From comparisons of 5000 m races just before, during and just after the Nagano Olympics and an analysis of historic world record data of the 1500 m men’s speed skating, the impact of the zigzag tape turbulators on average lap times on 1500 and 5000 m races is calculated to be about 0.5 s.
Stability of Weak Solutions to Parabolic Problems with Nonstandard Growth and Cross–Diffusion
Authors: Erhardt André H.
Published: January 2021

We study the stability of a unique weak solution to certain parabolic systems with nonstandard growth condition, which are additionally dependent on a cross-diffusion term. More precisely, we show that two unique weak solutions of the considered system with different initial values are controlled by their initial values.
Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice
Authors: Finamor Isabela A. , Bressan Caroline A. , Torres-Cuevas Isabel , Rius-Pérez Sergio , da Veiga Marcelo , Rocha Maria I. , Pavanato Maria A. , Pérez Salvador
Published: January 2021

Background: Aspartame is an artificial sweetener used in foods and beverages worldwide. However, it is linked to oxidative stress, inflammation, and liver damage through mechanisms that are not fully elucidated yet. This work aimed to investigate the effects of long-term administration of aspartame on the oxidative and inflammatory mechanisms associated with liver fibrosis progression in mice. Methods: Mice were divided into two groups with six animals each: control and aspartame. Aspartame (80 mg/kg, via oral) or vehicle was administrated for 12 weeks. Results: Aspartame caused liver damage and elevated serum transaminase levels. Aspartame also generated liver fibrosis, as evidenced by histology analysis, and pro-fibrotic markers’ upregulation, including transforming growth factor β 1, collagen type I alpha 1, and alpha-smooth muscle actin. Furthermore, aspartame reduced nuclear factor erythroid 2-related factor 2 (Nrf2) activation and enzymatic antioxidant activity and increased lipid peroxidation, which triggered NOD-like receptor containing protein 3 (NLRP3) inflammasome activation and p53 induction. Furthermore, aspartame reduced peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) levels, possibly through p53 activation. This PGC-1α deficiency could be responsible for the changes in lipid profile in serum, total lipid accumulation, and gluconeogenesis impairment in liver, evidenced by the gluconeogenic enzymes’ downregulation, thus causing hypoglycemia. Conclusions: This work provides new insights to understand the mechanisms related to the adverse effects of aspartame on liver tissue.
Cerebrospinal Fluid Levels of Chromogranin A in Parkinson’s Disease and Multiple System Atrophy
Authors: Kaiserova Michaela , Chudackova Monika , Mensikova Katerina , Vastik Miroslav , Kurcova Sandra , Prikrylova Vranova Hana , Stejskal David , Kanovsky Petr
Published: January 2021

Background: Chromogranin A (CgA) and other peptides from the chromogranin–secretogranin family have been recently studied as potential biomarkers of various neurodegenerative diseases, including Parkinson’s disease (PD). Methods: We measured CgA in the cerebrospinal fluid (CSF) of 119 PD patients, 18 multiple system atrophy (MSA) patients, and 31 age-matched controls. We also correlated the values with disease duration and levodopa dose equivalent. Results: In the PD patients, CSF CgA tended to be lower than the control group (median 124.5 vs. 185.2 µg/L; p = 0.057); however, the results did not reach statistical significance. CSF CgA levels in MSA were significantly lower compared to the control group (median 104.4 vs. 185.2; p = 0.014). There was no significant difference in CSF CgA between PD and MSA patients (p = 0.372). There was no association between CSF CgA and disease duration or levodopa dose equivalent in PD or in MSA. Conclusions: We observed a tendency toward lower CSF CgA levels in both PD and MSA compared to the control group; however, the difference reached statistical significance only in MSA. Based on these results, CgA may have potential as a biomarker in PD and MSA, but further studies on larger numbers of patients are needed to draw conclusions.
TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish
Authors: Campanari Maria-Letizia , Marian Anca , Ciura Sorana , Kabashi Edor
Published: January 2021

The “distal axonopathy” hypothesis in amyotrophic lateral sclerosis (ALS) proposes that pathological changes occur at the neuromuscular junction (NMJ) early in the disease. While acetylcholinesterase (AChE) plays an important role in the functionality of the NMJ, its potential role in ALS remains unexplored. Here, we identified AChE as a limiting factor regulating muscle/motor neuron connection in a vertebrate model of ALS. Knockdown of the TAR DNA-binding protein 43 (TDP-43) orthologue in zebrafish resulted in early defects of motor functions coupled with NMJ disassembly. We found that a partially depleted tdp-43 caused a decrease of ache expression. Importantly, human AChE overexpression reduced the phenotypic defects in the tdp-43 loss of function model, with amelioration of post- and pre-synaptic deficits at the NMJ. In conclusion, our results provide a better understanding of the role of TDP-43 in the NMJ organization and indicate AChE as a contributing factor in the pathology of ALS. In particular, it may be implicated in the early defects that characterize NMJs in this major neurodegenerative disorder.
Influence of Growth Defects on the Oxidation Resistance of Sputter-Deposited TiAlN Hard Coatings
Authors: Panjan Peter , Drnovšek Aljaž , Dražić Goran
Published: January 2021

This paper reports the results of an investigation of the oxidation of a sputter-deposited TiAlN hard coating in air at temperatures of 800 and 850 °C for times ranging from 15 min to 2 h. The study is focused on the role of growth defects in the oxidation process. The mechanism of oxidation at the site of the defect was studied on cross-sections made by the consecutive sectioning of oxidized coatings with the FIB technique. We found that in the early stage of oxidation, the locally intense oxidation always starts at such defects. Although the growth defects reduce the oxidation resistance of the coating locally, we believe that they do not have a decisive influence on the global oxidation resistance of the coating. There are several reasons for this. The first is that the surface area covered by growth defects is relatively low (less than 1%). Secondly, the coating is permeable only at those defects that extend through the entire coating thickness. Thirdly, the permeability at the rim of some defects strongly depends on the density of pores at the rim of defects and how open they are. The size and density of such pores depend on the shape and size of topographical irregularities on the substrate surface (e.g., seeds, pits), which are responsible for the formation of growth defects. We also found that oxidation of the TiAlN coating is accelerated by oxygen and titanium diffusion through the pores formed by crystal grain growth in the outer alumina overlayer. Such pores are formed due to the compressive stresses in the Ti-rich oxide layer, which are caused by the large difference in molar volumes between the oxide and nitride phases.
Impact Performance of Steel Fiber-Reinforced Self-Compacting Concrete against Repeated Drop Weight Impact
Authors: Abid Sallal R. , Gunasekaran Murali , Ali Sajjad H. , Kadhum Ahmed L. , Al-Gasham Thaar S. , Fediuk Roman , Vatin Nikolai , Karelina Maria
Published: January 2021

The self-compacting concrete (SCC) was invented to overcome the compaction problems in deep sections, owing to its perfect workability characteristics. Steel fibers when used with SCC would affect the required fluidity characteristics but improve its impact resistance. In this research, an experimental work was conducted to evaluate the impact response of micro-steel fiber-reinforced SCC, under flexural impact. A 5.47 kg free-falling mass was dropped repeatedly from 100 mm height on the top center of 270 mm-length beam specimens. Eight mixtures with two design grades of 30 and 50 MPa were prepared to distinguish the normal and high-strength SCCs. The distinguishing variable for each design grade was the fiber content, where four volumetric contents of 0%, 0.5%, 0.75%, and 1.0% were used. The test results showed that the impact resistance and ductility were significantly improved due to the incorporation of micro-steel fibers. The percentage improvements were noticeably higher at failure stage than at cracking stage. For the 30 MPa mixtures, the maximum percentage improvements at cracking and failure stages were 543% and 836%, respectively. Weibull’s linear correlations with R2 values of 0.84 to 0.97 were obtained at the failure stage, which meant that the impact failure number followed the Wiebull distribution.
LungINFseg: Segmenting COVID-19 Infected Regions in Lung CT Images Based on a Receptive-Field-Aware Deep Learning Framework
Authors: Kumar Singh Vivek , Abdel-Nasser Mohamed , Pandey Nidhi , Puig Domenec
Published: January 2021

COVID-19 is a fast-growing disease all over the world, but facilities in the hospitals are restricted. Due to unavailability of an appropriate vaccine or medicine, early identification of patients suspected to have COVID-19 plays an important role in limiting the extent of disease. Lung computed tomography (CT) imaging is an alternative to the RT-PCR test for diagnosing COVID-19. Manual segmentation of lung CT images is time consuming and has several challenges, such as the high disparities in texture, size, and location of infections. Patchy ground-glass and consolidations, along with pathological changes, limit the accuracy of the existing deep learning-based CT slices segmentation methods. To cope with these issues, in this paper we propose a fully automated and efficient deep learning-based method, called LungINFseg, to segment the COVID-19 infections in lung CT images. Specifically, we propose the receptive-field-aware (RFA) module that can enlarge the receptive field of the segmentation models and increase the learning ability of the model without information loss. RFA includes convolution layers to extract COVID-19 features, dilated convolution consolidated with learnable parallel-group convolution to enlarge the receptive field, frequency domain features obtained by discrete wavelet transform, which also enlarges the receptive field, and an attention mechanism to promote COVID-19-related features. Large receptive fields could help deep learning models to learn contextual information and COVID-19 infection-related features that yield accurate segmentation results. In our experiments, we used a total of 1800+ annotated CT slices to build and test LungINFseg. We also compared LungINFseg with 13 state-of-the-art deep learning-based segmentation methods to demonstrate its effectiveness. LungINFseg achieved a dice score of 80.34% and an intersection-over-union (IoU) score of 68.77%—higher than the ones of the other 13 segmentation methods. Specifically, the dice and IoU scores of LungINFseg were 10% better than those of the popular biomedical segmentation method U-Net.
Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications
Authors: Tsurusaki Masakatsu , Sofue Keitaro , Hori Masatoshi , Sasaki Kosuke , Ishii Kazunari , Murakami Takamichi , Kudo Masatoshi
Published: January 2021

Dual-energy computed tomography (DECT) is an imaging technique based on data acquisition at two different energy settings. Recent advances in CT have allowed data acquisitions and simultaneous analyses of X-rays at two energy levels, and have resulted in novel developments in the field of abdominal imaging. The use of low and high X-ray tube voltages in DECT provide fused images that improve the detection of liver tumors owing to the higher contrast-to-noise ratio (CNR) of the tumor compared with the liver. The use of contrast agents in CT scanning improves image quality by enhancing the CNR and signal-to-noise ratio while reducing beam-hardening artifacts. DECT can improve detection and characterization of hepatic abnormalities, including mass lesions. The technique can also be used for the diagnosis of steatosis and iron overload. This article reviews and illustrates the different applications of DECT in liver imaging.
Novel Effective Yeast Strains and Their Performance in High Gravity and Very High Gravity Ethanol Fermentations from Sweet Sorghum Juice
Authors: Laopaiboon Lakkana , Suporn Suntaree , Klanrit Preekamol , Phukoetphim Niphaphat , Daengbussadee Chalida , Laopaiboon Pattana
Published: January 2021

Yeasts were isolated from four potential sources, sweet sorghum juice, sugar cane juice, grapes and rambutan. The 27 yeast isolates were tested for their ethanol tolerance (15% v/v of ethanol) and ethanol fermentation performance in a synthetic ethanol production medium (200 g/L of total sugar). Only five isolates, SCJ04KKU, SCJ07KKU, SCJ09KKU, SCJ14KKU and SSJ01KKU could tolerate 15% ethanol and produce ethanol at levels higher than 55 g/L. The ethanol production efficiency from sweet sorghum juice under high gravity (HG, 200 and 240 g/L of total sugar) and very high gravity (VHG, 280 g/L of total sugar) conditions of the five isolates was tested. Saccharomyces cerevisiae NP01 and S. cerevisiae ATCC4132 were used as reference strains. The results showed that the SSJ01KKU isolate gave the highest ethanol production efficiency under all conditions. Ethanol concentration (PE), yield (YP/S) and productivity (QP) values were 98.89 g/L, 0.50 and 1.18 g/L·h, respectively, with sugar consumption (SC) of 98.96% under the HG condition at 200 g/L of total sugar. Under the HG condition at 240 g/L of total sugar, the PE, YP/S and QP values were 118.12 g/L, 0.51 and 1.41 g/L·h, respectively, with the SC of 95.79%. These values were 82.29 g/L, 0.34 and 0.98 g/L·h, respectively, with the SC of 85.59% under the VHG condition. Addition of urea into the sweet sorghum juice under all conditions significantly shortened the fermentation time, resulting in increased QP values. Based on molecular taxonomic analysis of the five isolates using sequence analysis of the D1/D2 domain and the ITS1 and ITS2 regions, SSJ01KKU is S. cerevisiae, whereas SCJ04KKU, SCJ07KKU, SCJ09KKU and SCJ14KKU are Pichia caribbica.
Senescence: The Compromised Time of Death That Plants May Call on Themselves
Authors: Miryeganeh Matin
Published: January 2021

Plants synchronize their life history events with proper seasonal conditions, and as the fitness consequences of each life stage depend on previous and/or subsequent one, changes in environmental cues create cascading effects throughout their whole life cycle. For monocarpic plants, proper senescence timing is very important as the final production of plants depends on it. Citing available literatures, this review discusses how plants not only may delay senescence until after they reproduce successfully, but they may also bring senescence time forward, in order to reproduce in favored conditions. It demonstrates that even though senescence is part of aging, it does not necessarily mean plants have to reach a certain age to senesce. Experiments using different aged plants have suggested that in interest of their final outcome and fitness, plants carefully weigh out environmental cues and transit to next developmental phase at proper time, even if that means transiting to terminal senescence phase earlier and shortening their lifespan. How much plants have control over senescence timing and how they balance internal and external signals for that is not well understood. Future studies are needed to identify processes that trigger senescence timing in response to environment and investigate genetic/epigenetic mechanisms behind it.
The FLA4-FEI Pathway: A Unique and Mysterious Signaling Module Related to Cell Wall Structure and Stress Signaling
Authors: Seifert Georg J.
Published: January 2021

Cell wall integrity control in plants involves multiple signaling modules that are mostly defined by genetic interactions. The putative co-receptors FEI1 and FEI2 and the extracellular glycoprotein FLA4 present the core components of a signaling pathway that acts in response to environmental conditions and insults to cell wall structure to modulate the balance of various growth regulators and, ultimately, to regulate the performance of the primary cell wall. Although the previously established genetic interactions are presently not matched by intermolecular binding studies, numerous receptor-like molecules that were identified in genome-wide interaction studies potentially contribute to the signaling machinery around the FLA4-FEI core. Apart from its function throughout the model plant Arabidopsis thaliana for the homeostasis of growth and stress responses, the FLA4-FEI pathway might support important agronomic traits in crop plants.
Photosynthesis and Related Physiological Parameters Differences Affected the Isoprene Emission Rate among 10 Typical Tree Species in Subtropical Metropolises
Authors: Lyu Junyao , Xiong Feng , Sun Ningxiao , Li Yiheng , Liu Chunjiang , Yin Shan
Published: January 2021

Volatile organic compound (VOCs) emission is an important cause of photochemical smog and particulate pollution in urban areas, and urban vegetation has been presented as an important source. Different tree species have different emission levels, so adjusting greening species collocation is an effective way to control biogenic VOC pollution. However, there is a lack of measurements of tree species emission in subtropical metropolises, and the factors influencing the species-specific differences need to be further clarified. This study applied an in situ method to investigate the isoprene emission rates of 10 typical tree species in subtropical metropolises. Photosynthesis and related parameters including photosynthetic rate, intercellular CO2 concentration, stomatal conductance, and transpiration rate, which can influence the emission rate of a single species, were also measured. Results showed Salix babylonica always exhibited a high emission level, whereas Elaeocarpus decipiens and Ligustrum lucidum maintained a low level throughout the year. Differences in photosynthetic rate and stomatal CO2 conductance are the key parameters related to isoprene emission among different plants. Through the establishment of emission inventory and determination of key photosynthetic parameters, the results provide a reference for the selection of urban greening species, as well as seasonal pollution control, and help to alleviate VOC pollution caused by urban forests.
The History, Efficacy, and Safety of Potential Therapeutics: A Narrative Overview of the Complex Life of COVID-19
Authors: Daou Farah , Abou-Sleymane Gretta , Badro Danielle A. , Khanafer Nagham , Tobaiqy Mansour , Al Faraj Achraf
Published: January 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic posed a serious public health concern and started a race against time for researchers to discover an effective and safe therapy for coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2. This review aims to describe the history, efficacy, and safety of five potential therapeutics for COVID-19, remdesivir, favipiravir, hydroxychloroquine, tocilizumab, and convalescent plasma. A literature review was conducted through October 2020 to identify published studies evaluating the efficacy and safety of these five potential therapeutics. Clinical improvement was used to assess the efficacy, while reported withdrawals from study participation and adverse events were used to evaluate the safety. In total, 95 clinical studies (6 interventional and 89 observational studies) were obtained, of which 42 were included in this review. The evaluation of the efficacy and safety profiles is challenging due to the limitations of the clinical studies on one hand, and the limited number of randomized controlled trials (RCTs) on the other. Moreover, there was insufficient evidence to support repurposing remdesivir, favipiravir, and tocilizumab for COVID-19.
Where to Ride? An Explorative Study to Investigate Potential Risk Factors of Personal Mobility Accidents
Authors: Oh Jihun , Kim Jeongseob
Published: January 2021

As a mobility of future, the popularity of personal mobility vehicles (PMs) is rapidly increasing worldwide. However, this boom in the use of PMs has resulted in a substantial number of accidents involving not only PM users but also other road users including pedestrians, bicyclists, and motor vehicle drivers. This study aims to explore the potential risk factors for the occurrence of PM-related accidents and the resulting injury severity using the Traffic Accident Analysis System (TAAS) of South Korea between 2017 and 2019. We found that PM–pedestrian accidents tend to occur on roads with wider sidewalks and bike lanes, possibly because the pedestrian–PM conflict increases in this road condition. There is still ongoing debate on whether it is appropriate for PMs to share the sidewalk with pedestrians. Some countries, including Korea, prohibit the use of PMs on sidewalks; however, in reality, this regulation is not well-observed because using PMs on roadways involves higher crash risk with motor vehicles. This study suggests one potential solution to ensure safety of PM users: expansion of bike lane infrastructure having physically separated bike lanes and sidewalks/motorways in addition to the formation and strict enforcement of appropriate safety rules for PM users.
Spotting Loneliness at School: Associations between Self-Reports and Teacher and Peer Nominations
Authors: Geukens Flore , Maes Marlies , Cillessen Antonius H. N. , Colpin Hilde , Van Leeuwen Karla , Verschueren Karine , Goossens Luc
Published: January 2021

In two independent studies, we aimed to examine the extent to which teacher and peer nominations of loneliness are associated with children’s and adolescents’ self-reported loneliness, respectively. Additionally, we examined whether loneliness nominations from teachers and peers were informative above and beyond peer status and social behaviors associated with loneliness. In Study 1 (N = 1594, Mage = 9.43 years), teacher nominations of loneliness showed a small to moderate correlation with children’s self-reported loneliness as assessed using the Loneliness and Social Dissatisfaction Questionnaire (LSDQ). The results of a hierarchical regression analysis showed that teacher nominations of loneliness predicted children’s self-reported loneliness above and beyond teacher nominations of peer status and social behaviors. In Study 2 (N = 350, Mage = 13.81 years), peer nominations of loneliness showed a small to moderate correlation with adolescents’ self-reported loneliness as assessed using the peer-related loneliness subscale of the Loneliness and Aloneness Scale for Children and Adolescents (LACA). The results of a hierarchical regression analysis showed that peer nominations of loneliness predicted adolescents’ self-reported loneliness above and beyond peer nominations of peer status and social behaviors. We conclude that loneliness nominations are valuable, but caution is needed when they are used exclusively to identify lonely children and adolescents.
Genetic Scores of eNOS, ACE and VEGFA Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women
Authors: Singh Puneetpal , Singh Monica , Khinda Rubanpal , Valecha Srishti , Kumar Nitin , Singh Surinderpal , Juneja Pawan K. , Kaur Taranpal , Mastana Sarabjit
Published: January 2021

The present study aimed to examine the participation and contribution of endothelial nitric oxide synthase (eNOS), angiotensin converting enzyme (ACE) and vascular endothelial growth factor (VEGFA) genes for the risk of endothelial dysfunction (ED)-associated osteoporosis risk in postmenopausal women of Punjab, India. Women with ED were categorized into women with osteoporosis (n = 346) and women without osteoporosis (n = 330). They were examined for selected SNPs within eNOS, ACE and VEGFA genes. Linear regression analysis revealed a positive association of ED with bone mineral densities (BMDs) at femoral neck (r2 = 0.78, p < 0.001) and lumbar spine (r2 = 0.24, p = 0.001) after Bonferroni correction. Three susceptibility haplotypes were exposed within eNOS (CTAAAT), ACE (ACDG) and VEGFA (GATA) genes. Bearers of CTAAAT (OR 2.43, p = 0.007), ACDG (OR 2.50, p = 0.002) and GATA (OR 2.10, p = 0.009) had substantial impact for osteoporosis after correcting the effects with traditional risk factors (TRD).With uncertainty measure (R2h) and Akaike information criterion (AIC), best fit models showed that CTAAAT manifested in multiplicative mode (β ± SE: 2.19 ± 0.86, p < 0.001), whereas ACDG (β ± SE: 1.73 ± 0.54, p = 0.001) and GATA (β ± SE: 3.07 ± 0.81, p < 0.001) expressed in dominant modes. Area under receiver operating characteristic curve using weighted risk scores (effect estimates) showed substantial strength for model comprising TRD + GATA (AUC = 0.8, p < 0.001) whereas, model comprising TRD + GATA + CTAAAT exhibited excellent ability to predict osteoporosis (AUC = 0.824, p < 0.001)
Navigational Needs and Preferences of Hospital Patients and Visitors: What Prospects for Smart Technologies?
Authors: Ženka Jan , Macháček Jan , Michna Pavel , Kořízek Pavel
Published: January 2021

In this paper, we map navigational needs and preferences of patients and visitors to evaluate the appropriateness of a smartphone navigation application in the hospital in contrast to other, more traditional navigational cues. We test the effects of sociodemographic variables (age, gender, education) on wayfinding strategies and preferences of respondents (using chi2 tests). Empirical research is based on the survey among 928 patients/visitors of the Vítkovice Hospital in Ostrava, Czechia. We found a relatively weak association between gender and wayfinding—no major differences between men and women in navigational preferences were found. Age was the most important predictor of wayfinding. Respondents in the over-60-year age group were characteristic of a lower interest in changes of the navigational system and low willingness to use mobile applications for navigation—people between 41 years and 60 years were the biggest supporters of changes. Correspondingly, demand for improvement of navigation (including a mobile application) was positively correlated with educational level.
Effect of Nurses’ Preceptorship Experience in Educating New Graduate Nurses and Preceptor Training Courses on Clinical Teaching Behavior
Authors: Hong Kyung Jin , Yoon Hyo-Jeong
Published: January 2021

Only few studies have examined the preceptor training courses and their effects on clinical teaching behaviors (CTBs) of preceptors. This study investigated preceptors’ experiences in educating new graduate nurses and the effect they had on clinical teaching behavior (CTB) based on whether they participated in a preceptor training program. A descriptive online survey method was used, and the participants included 180 registered nurses who were preceptors. The Clinical Teaching Behavior Inventory (CTBI-22) was used, and perceptions of teaching experiences were measured by six items. Data were analyzed using multiple linear regression. Preceptors working at general hospitals or hospitals were less likely to have participated in a preceptor training program than those working at tertiary hospitals. The overall mean score of CTB was 89.30, and “guiding inter-professional communication” showed the lowest mean score. Positive perceptions of preceptorship experiences were positively related with CTB, and the number of precepting experiences affected CTB only for nurses having undergone preceptor training courses. The use of role-playing as a method in training courses positively affected preceptors’ CTB. These findings suggest that preceptors need support from nurse managers and colleagues, and preceptor training programs should be developed.
Trends in Pediatric Candidemia: Epidemiology, Anti-Fungal Susceptibility, and Patient Characteristics in a Children’s Hospital
Authors: Piqueras Anabel , Ganapathi Lakshmi , Carpenter Jane F. , Rubio Thomas , Sandora Thomas J. , Flett Kelly B. , Köhler Julia R.
Published: January 2021

Candida bloodstream infections (CBSIs) have decreased among pediatric populations in the United States, but remain an important cause of morbidity and mortality. Species distributions and susceptibility patterns of CBSI isolates diverge widely between children and adults. The awareness of these patterns can inform clinical decision-making for empiric or pre-emptive therapy of children at risk for candidemia. CBSIs occurring from 2006–2016 among patients in a large children’s hospital were analyzed for age specific trends in incidence rate, risk factors for breakthrough-CBSI, and death, as well as underlying conditions. Candida species distributions and susceptibility patterns were evaluated in addition to the anti-fungal agent use. The overall incidence rate of CBSI among this complex patient population was 1.97/1000 patient-days. About half of CBSI episodes occurred in immunocompetent children and 14% in neonatal intensive care unit (NICU) patients. Anti-fungal resistance was minimal: 96.7% of isolates were fluconazole, 99% were micafungin, and all were amphotericin susceptible. Liposomal amphotericin was the most commonly prescribed anti-fungal agent included for NICU patients. Overall, CBSI-associated mortality was 13.7%; there were no deaths associated with CBSI among NICU patients after 2011. Pediatric CBSI characteristics differ substantially from those in adults. The improved management of underlying diseases and antimicrobial stewardship may further decrease morbidity and mortality from CBSI, while continuing to maintain low resistance rates among Candida isolates.
Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Authors: Talapko Jasminka , Juzbašić Martina , Matijević Tatjana , Pustijanac Emina , Bekić Sanja , Kotris Ivan , Škrlec Ivana
Published: January 2021

Candida albicans is a common commensal fungus that colonizes the oropharyngeal cavity, gastrointestinal and vaginal tract, and healthy individuals’ skin. In 50% of the population, C. albicans is part of the normal flora of the microbiota. The various clinical manifestations of Candida species range from localized, superficial mucocutaneous disorders to invasive diseases that involve multiple organ systems and are life-threatening. From systemic and local to hereditary and environmental, diverse factors lead to disturbances in Candida’s normal homeostasis, resulting in a transition from normal flora to pathogenic and opportunistic infections. The transition in the pathophysiology of the onset and progression of infection is also influenced by Candida’s virulence traits that lead to the development of candidiasis. Oral candidiasis has a wide range of clinical manifestations, divided into primary and secondary candidiasis. The main supply of C. albicans in the body is located in the gastrointestinal tract, and the development of infections occurs due to dysbiosis of the residential microbiota, immune dysfunction, and damage to the muco-intestinal barrier. The presence of C. albicans in the blood is associated with candidemia–invasive Candida infections. The commensal relationship exists as long as there is a balance between the host immune system and the virulence factors of C. albicans. This paper presents the virulence traits of Candida albicans and clinical manifestations of specific candidiasis.
UPLC-MS-Based Metabolomics Profiling for α-Glucosidase Inhibiting Property of Parkia speciosa Pods
Authors: Saleh Mohammed S. M. , Jalil Juriyati , Mustafa Nor Hidayah , Ramli Fitri Fareez , Asmadi Ahmad Yusof , Kamisah Yusof
Published: January 2021

Parkia speciosa is a food plant that grows indigenously in Southeast Asia. A great deal of interest has been paid to this plant due to its traditional uses in the treatment of several diseases. The pods contain many beneficial secondary metabolites with potential applications in medicine and cosmetics. However, studies on their phytochemical properties are still lacking. Therefore, the present study was undertaken to profile the bioactive compounds of P. speciosa pods collected from six different regions of Malaysia through ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) and α-glucosidase inhibitory potential. This study applied metabolomics to elucidate the differences between P. speciosa populations found naturally in the different locations and to characterize potential α-glucosidase inhibitors from P. speciosa pods. P. speciosa collected from different regions of Malaysia showed good α-glucosidase inhibitory activity, with a median inhibitory concentration (IC50) of 0.45–0.76 μg/mL. The samples from the northern and northeastern parts of Peninsular Malaysia showed the highest activity. Using UHPLC-QTOF-MS/MS analysis, 25 metabolites were identified in the pods of P. speciosa. The findings unveiled that the pods of P. speciosa collected from different locations exhibit different levels of α-glucosidase inhibitory activity. The pods are a natural source of potent antidiabetic bioactive compounds.
Free Energy of Metals from Quasi-Harmonic Models of Thermal Disorder
Authors: Korzhavyi Pavel A. , Zhang Jing
Published: January 2021

A simple modeling method to extend first-principles electronic structure calculations to finite temperatures is presented. The method is applicable to crystalline solids exhibiting complex thermal disorder and employs quasi-harmonic models to represent the vibrational and magnetic free energy contributions. The main outcome is the Helmholtz free energy, calculated as a function of volume and temperature, from which the other related thermophysical properties (such as temperature-dependent lattice and elastic constants) can be derived. Our test calculations for Fe, Ni, Ti, and W metals in the paramagnetic state at temperatures of up to 1600 K show that the predictive capability of the quasi-harmonic modeling approach is mainly limited by the electron density functional approximation used and, in the second place, by the neglect of higher-order anharmonic effects. The developed methodology is equally applicable to disordered alloys and ordered compounds and can therefore be useful in modeling realistically complex materials.
The Interface and Fabrication Process of Diamond/Cu Composites with Nanocoated Diamond for Heat Sink Applications
Authors: Li Yaqiang , Zhou Hongyu , Wu Chunjing , Yin Zheng , Liu Chang , Huang Ying , Liu Junyou , Shi Zhongliang
Published: January 2021

The coefficients of thermal expansion (CTE) and thermal conductivity (TC) are important for heat sink applications, as they can minimize stress between heat sink substrates and chips and prevent failure from thermal accumulation in electronics. We investigated the interface behavior and manufacturing of diamond/Cu composites and found that they have much lower TCs than copper due to their low densities. Most defects, such as cavities, form around diamond particles, substantially decreasing the high TC of diamond reinforcements. However, the measurement results for the Cu-coated diamond/Cu composites are unsatisfactory because the nanosized copper layer on the diamond surface grew and spheroidized at elevated sintering temperatures. Realizing ideal interfacial bonding between a copper matrix and diamond particles is difficult. The TC of the 40 vol.% Ti-coated diamond/Cu composite is 475.01 W m−1 K−1, much higher than that of diamond/Cu and Cu-coated diamond/Cu composites under equivalent manufacturing conditions. The minimally grown titanium layer retained its nanosized and was consistent with the sintering temperature. Depositing a nanosized titanium layer on a diamond surface will strengthen interfacial bonding through interface reactions among the copper matrix, nanosized titanium layer and diamond particles, reducing the interfacial thermal resistance and exploiting the high TC of diamond particles, even if defects from powder metallurgy remain. These results provide an important experimental and theoretical basis for manufacturing diamond/Cu composites for heat sink applications.