bluuebunny/crossref_metadata_2025 huggingface dataset:
The coherence function and lithospheric elastic thickness of the Zagros fold and thrust belt
Authors: Ghalehnovi Samira , Ardestani Vahid E , Pysklywec Russell N , Balouch Mehrdad
Published: April 2023

This study derives the spatial variation of the elastic thickness (Te) and its implications for understanding the structure, geodynamic and seismicity of the lithosphere for the Zagros fold and thrust belt region of the Arabia–Eurasia collision zone. Te is calculated using the coherence function in the fan wavelet domain based on recent terrestrial Bouguer gravity and topography data as input signals. Utilizing the load deconvolution method and Brent's method of 1-D minimization, the final Te for the survey region is estimated for each grid node of the studied area. To illustrate the mass distribution in the studied area, the subsurface loading fraction (F) is calculated simultaneously with Te in the inversion. The crust thickness and density from three different global crustal models are tested and the results obtained for these input models do not yield substantially different Te patterns. The final results are in accord with the global Te models as well as previous rheological, geodynamical and flexural studies, however, this study establishes much more detailed regional information. The calculations yield a mean value of Te of 61 km for the Zagros, with a mean estimated error of about 5 km. The high-Te values (>70 km) are observed in the southeast of the studied area (some parts of the Sanandaj–Sirjan zone, Urumieh–Dokhtar magmatic arc and most of the Central Iranian blocks); while over most of the northwest of the studied area, the value of Te is about 58 km. The Te results are consistent with the lithospheric structure of the study area and also support the idea of the crust–mantle decoupling. Further, there is a positive and negative correlation between the surface wave velocity and surface heat flow, respectively. The mean value estimated for the internal loading friction (F) of 0.4 means in most of the studied areas we may consider that the surface loading is dominant, or at least the ratio of the surface and subsurface loading can be assumed equal. Based on earthquake distribution in the period 1900–2020, seismicity is more likely to occur in areas with a relatively low value of Te.
On performance of vertical gravity gradient determined from CryoSat-2 altimeter data over Arabian Sea
Authors: Zhou Ruichen , Liu Xin , Li Zhen , Sun Yu , Yuan Jiajia , Guo Jinyun , Ardalan Alireza A
Published: April 2023

High-precision and high-resolution satellite altimetry data from CryoSat-2 are widely utilized for marine gravity inversion. The vertical gravity gradient is a crucial parameter of the Earth's gravity field. To evaluate the performance of vertical gravity gradient determined from CryoSat-2 altimeter data, the pre-processed along-track sea surface heights (SSHs) are obtained through error correction. The study area focused on the Arabian Sea and its surrounding region, where the along-track geoid was derived by subtracting the mean dynamic topography of the ocean from the along-track SSH of CryoSat-2. The residual along-track geoidal gradients were obtained by adjusting the along-track geoid gradients calculated from CryoSat-2 altimeter data using the remove-restore method. This was done by subtracting the geoid gradients calculated by the gravity field model XGM2019e_2159. After obtaining the residual along-track geoidal gradients, the residual gridded deflections of the vertical (DOV) are calculated using the least-squares collocation (LSC) method. The residual gridded DOV are then used to compute the residual gridded gravity anomaly gradients in the study area using the finite-difference method. After restoring the gravity anomaly gradients computed by the XGM2019e_2159 model, a high-resolution gravity anomaly gradient model with a resolution of 1′ ×1′ is obtained for the Arabian Sea and its surrounding area. To evaluate the accuracy of the gravity anomaly gradient model derived from CryoSat-2, it was compared with the SIO V32.1 gravity anomaly gradient model released by the Scripps Institution of Oceanography. The comparison showed that the root mean square (RMS) of the differences between the two models is 7.69E, demonstrating the high accuracy and precision of the vertical gravity gradient determined from CryoSat-2 altimeter data.
Re-imagining Reproduction: The Queer Possibilities of Plants
Authors: Subramaniam Banu , Bartlett Madelaine
Published: April 2023

Synopsis

How did plant sexuality come to so hauntingly resemble human sexual formations? How did plant biology come to theorize plant sexuality with binary formulations of male/female, sex/gender, sperm/egg, active males and passive females—all of which resemble western categories of sex, gender, and sexuality? Tracing the extant language of sex and sexuality in plant reproductive biology, we examine the histories of science to explore how plant reproductive biology emerged historically from formations of colonial racial and sexual politics and how evolutionary biology was premised on the imaginations of racialized heterosexual romance. Drawing on key examples, the paper aims to (un)read plant sexuality and sexual anatomy and bodies to imagine new possibilities for plant sex, sexualities, and their relationalities. In short, plant sex and sexuality are not two different objects of inquiry but are intimately related—it is their inter-relation that is the focus of this essay. One of the key impulses from the humanities that we bring to this essay is a careful consideration of how terms and terminologies are related to each other historically and culturally. In anthropomorphizing plants, if plant sexuality were modeled on human sexual formations, might a re-imagination of plant sexuality open new vistas for the biological sciences? While our definitions of plant sexuality will always be informed by contemporary society and culture, interrogating the histories of our theories and terminologies can help us reimagine a biology that allows for new and more accurate understandings of plants, plant biology, and the evolution of reproduction.
Evaluating The Precocial-altricial Axis of Motor Skill at Birth in A Preterm Pig Model
Authors: Young Jesse W , Mayerl Christopher J , Mannava Alekhya , Lewis Claire , Fan Tianhui , Nair Manas , Mamone Christopher , Schapker Nicole M , Mossor Angela M , German Rebecca Z
Published: April 2023

The pace of locomotor development is a critical component of lifetime evolutionary fitness. Developmental researchers often divide species into two broad categories based on functional competence at birth: precocial infants who can independently stand and locomote soon after birth versus altricial infants who are either incapable of independent movement or can only do so in a rudimentary manner. However, investigating the lower level neuromotor and biomechanical traits that account for perinatal variation in motor development is complicated by the lack of experimental control inherent to all comparative analyses. Precocial and altricial animals often differ along a host of dimensions that can obfuscate the specific factors controlling motor development per se. Here, we propose an alternative approach of examining locomotor development in a nominally precocial species—the domestic pig (Sus scrofa)—in which gestation length has been experimentally manipulated, thereby creating “functionally altricial” cohorts for comparison. We have used standard biomechanical testing to evaluate balance and locomotor performance in preterm pigs born at 94% full-term gestation (N = 29 individuals) and compared these data to a similar dataset on age-matched full-term piglets (N = 15 individuals). Static balance tests showed that preterm pigs were characterized by increased postural sway, particularly in the fore-aft (anteroposterior) direction. Locomotor analyses showed that preterm piglets tended to take shorter, more frequent strides, use higher duty factors, and preferentially choose gait patterns that ensured they were supported by at least three limbs during most of the stride cycle, though differences between preterm and full-term animals were often modulated by variation in locomotor speed. Morphometric analysis showed no differences in relative extensor muscle mass between preterm and full-term animals, suggesting that neurological immaturity might be more determinant of preterm piglet motor dysfunctions than musculoskeletal immaturity per se (though much work remains to be done to fully document the neuromotor phenotype of the preterm infant pig model). In many ways, the postural and locomotor deficits shown by the preterm piglets paralleled the locomotor phenotype of altricial mammals. Overall, our study demonstrates the utility of a “within-species” design for studying the biomechanical correlates and neuromotor basis of evolutionary variation in motor skill at birth.
Is the “sailing-ship effect” misnamed? A statistical inquiry of the case sail vs steam in maritime transportation
Authors: De Liso Nicola , Arima Serena , Filatrella Giovanni
Published: April 2023

Improvements experienced by incumbent “old” technologies when threatened by new ones, potentially supplanting them, are often addressed as the “sailing-ship effect.” The latter phrase points to the eponymous case that consists of the 60-year or so technological battle between sail and steam in ships’ propulsion during the 19th century, which led to unexpected large advancements in sail technology. Paradoxically, until today, the only work which addressed quantitatively that technological battle actually found a lack of evidence of the occurrence of the sailing-ship effect. In this paper, through fresh statistical analysis, we find instead confirmation of the existence of the effect in the original case. This finding contributes to the theoretical debate that explains technological persistence through mechanisms such as path dependence, cumulativeness, localized technical progress, competence and cognitive traps, the presence of complementary assets and tributary innovations, as well as institutional features. Policy dimensions are considered in Section 7 of the work.
A four-drug standardized short regimen for highly resistant TB in South-West Nigeria
Authors: Fadeyi Muse O , Decroo Tom , Ortuño-Gutiérrez Nimer , Ahmed Bolaji , Jinadu Aderonke , El-Tayeb Osman , Adebola Wasiu , Kehinde Aderemi , Lynen Lutgarde , Gils Tinne
Published: April 2023

Background

Patients with TB resistant to rifampicin (Rr-TB), and those with additional resistance to fluoroquinolones (pre-XDR-TB), should be treated with bedaquiline-pretomanid-linezolid-moxifloxacin and bedaquiline-pretomanid-linezolid, respectively. However, pretomanid is not yet widely available.

Methods

This is a pragmatic prospective single-arm study investigating the efficacy and safety of 9 mo of bedaquiline-delamanid-linezolid-clofazimine in patients with pre-XDR-TB or Rr-TB unresponsive to Rr-TB treatment in Nigeria.

Results

From January 2020 to June 2022, 14 of 20 patients (70%) successfully completed treatment, five died and one was lost-to-follow-up. No one experienced a treatment-emergent grade three/four event. Treatment success was higher compared with global pre-XDR-TB treatment outcomes.

Conclusions

While pretomanid is unavailable, highly resistant TB can be treated with bedaquiline-delamanid-linezolid-clofazimine.
Enzymatic breakdown of biofilm matrix to allow flow cytometry viability analysis ofClostridium beijerinckiicells
Authors: Carrié Maxime , Gabelle Jean-Christophe , Lopes-Ferreira Nicolas , Velly Hélène
Published: April 2023

Aims

Flow cytometry (FC) is a good way to enumerate the number of viable cells in suspension but is not adapted to mature biofilm analysis. The aim of this study is to investigate the effect of mechanical treatment coupled with enzymatic hydrolysis of biofilm matrix on FC viability analysis of biofilm cells.

Methods and results

Biofilm was grown for 300 h of continuous fermentation on polyurethane foams. Fermentation was stopped, and the biofilm was detached by agitating the foams in PBS buffer with vortex agitation for 2 min. The best enzymatic hydrolysis consisted of sequential use of DNase I and proteinase K incubated for 1 h at 34°C. Biofilm cells detached from polyurethane foams were stained with both propidium iodide (PI) and carboxyfluoresceine diacetate and analyzed by FC. FC analysis performed after vortex agitation revealed the presence of high non-fluorescent events (78.9% ± 3.3%). After enzymatic treatment, a cell population was extracted from background noise and could be observed on FSC-SSC profile. The non-fluorescent events of this cell population decreased drastically to 41.9% ± 6.6%, and the percentage of viable cells was enhanced from 2.6% ± 0.9% to 38.2% ± 4.0% compared to analysis performed after mechanical treatment alone.

Conclusions

Consequently, protease and nuclease activity are essential to hydrolyze extra polymeric substances prior to FC viability analysis in mature biofilm formed by Clostridium beijerinckii.
Azole and 5-nitroimidazole based nanoformulations are potential antiamoebic drug candidates against brain-eating amoebae
Authors: Akbar Noor , Hussain Kashif , Khalid Maria , Siddiqui Ruqaiyyah , Shah Muhammad Raza , Khan Naveed Ahmed
Published: April 2023

Aim

Herein, the anti-parasitic activity of azoles (fluconazole and itraconazole) and 5-nitroimdazole (metronidazole) against the brain-eating amoebae: Naegleria fowleri and Balamuthia mandrillaris was elucidated.

Methods and results

Azoles and 5-nitroimidazole based nanoformulations were synthesized and characterized using a UV-visible spectrophotometer, atomic force microscopy, and fourier transform infrared spectroscopy. H1-NMR, EI-MS, and ESI-MS were performed to determine their molecular mass and elucidate their structures. Their size, zeta potential, size distribution, and polydispersity index (PDI) were assessed. Amoebicidal assays revealed that all the drugs and their nanoformulations, (except itraconazole) presented significant anti-amoebic effects against B. mandrillaris, while all the treatments indicated notable amoebicidal properties against N. fowleri. Amoebicidal effects were radically enhanced upon conjugating the drugs with nanoparticles. The IC50 values for KM-38-AgNPs-F, KM-20-AgNPs-M, and KM-IF were 65.09, 91.27, and 72.19 µg.mL-1, respectively, against B. mandrillaris. Whereas against N. fowleri, the IC50 values were: 71.85, 73.95, and 63.01 µg.mL-1, respectively. Additionally, nanoformulations significantly reduced N. fowleri-mediated host cell death, while nanoformulations along with fluconazole and metronidazole considerably reduced Balamuthia-mediated human cell damage. Finally, all the tested drugs and their nanoformulations revealed limited cytotoxic activity against human cerebral microvascular endothelial cell (HBEC-5i) cells.

Conclusion

These compounds should be developed into novel chemotherapeutic options for use against these distressing infections due to free-living amoebae, as currently there are no effective treatments.
Identification of 11-nor-∆8-Tetrahydrocannabinol-9-Carboxylic Acid in Postmortem Urine
Authors: Crosby Michele M , Truver Michael T , Chronister Chris W , Hoyer Jennifer L , Kinsey Amy M , Brogan Sara C , Goldberger Bruce A
Published: April 2023

Laws concerning the growing, selling and consuming of cannabis and its related products have been changing considerably over the last few years. The legalization of hemp in 2018 sparked an interest in ∆9-tetrahydrocannabinol (∆9-THC) isomers and analogs that are derived from hemp and sold with minimal oversight. One example is ∆8-tetrahydrocannabinol (∆8-THC). Although less potent than ∆9-THC, ∆8-THC is gaining popularity and can easily be found where cannabis-related products are sold. The Forensic Toxicology Laboratory at the University of Florida routinely tested decedents for 11-nor-∆9-tetrahydrocannabinol-9-carboxylic acid (∆9-THC-acid), the primary metabolite of ∆9-THC. Urine samples from ∼900 decedents were received by the laboratory between mid-November 2021 and mid-March 2022 and subjected to CEDIA™ immunoassay testing. Subsequent confirmation of 194 presumptive positive samples was performed by gas chromatography--mass spectrometry. A peak eluting immediately after ∆9-THC-acid was identified as 11-nor-∆8-tetrahydrocannabinol-9-carboxylic acid (∆8-THC-acid), a metabolite of ∆8-THC, in 26 of those samples (13%). Six of the samples were positive for ∆8-THC-acid only. Other toxicological findings were consistent with poly-drug use including fentanyl/fentanyl analogs, ethanol, cocaine and methamphetamine. There has been an emergence of ∆8-THC use as indicated by the presence of ∆8-THC-acid in 26 of 194 presumptive positive cases during a four-month period. The majority of individuals were White males with a history of drug and/or alcohol use. ∆9-THC-acid, as well as other drugs, was often present. Given the psychoactive potential and availability of ∆8-THC, monitoring ∆8-THC-acid in decedents is important to characterize the risk and prevalence of ∆8-THC use.
Topology optimization for additive manufacturing with strength constraints considering anisotropy
Authors: Zou Jun , Xia Xiaoyu
Published: April 2023

Combining topology optimization and additive manufacturing (AM) is a promising approach to breaking through the limitations of conventional design and developing innovative structures with high performance. However, the unique manufacturing constraints in AM should be considered when developing the topology optimization algorithms for AM. Material anisotropy is one of the common characteristics of AM materials due to the layer-by-layer manufacturing techniques. This work proposes a topology optimization approach for AM with strength constraints considering anisotropy. The Hoffman failure criterion is adopted to represent the anisotropic strength behaviors of AM materials. Based on the Hoffman failure criteria and the p-norm measure aggregation function, a global strength constraint formulation is established. Under the framework of solid isotropic material with penalization, we develop a topology optimization methodology to minimize the structural weight or volume fraction subject to structural stiffness and strength constraints. Several two-dimensional (2D) or 3D numerical test cases are performed to validate the effectiveness and performance of the developed method. The results indicated that the proposed method could make full use of material properties by considering anisotropic strength. Besides, the topological optimization considering strength anisotropy could be combined with build direction optimization to further reduce the structural weight.
Blood meal source identification and RNA virome determination in Japanese encephalitis virus vectors collected in Ishikawa Prefecture, Japan, show distinct avian/mammalian host preference
Authors: Faizah Astri Nur , Kobayashi Daisuke , Matsumura Ryo , Watanabe Mamoru , Higa Yukiko , Sawabe Kyoko , Isawa Haruhiko
Published: April 2023

In Asia, Culex mosquitoes are of particular interest because of their role in maintaining endemic mosquito-borne viral diseases, including the Japanese encephalitis virus (JEV). Nonetheless, host-feeding preferences, along with naturally infecting RNA viruses in certain Culex species, remain understudied. In this study, selected blood-fed mosquitoes were processed for avian and mammalian blood meal source identification. Concurrently, cell culture propagation and high-throughput sequencing (HTS) approaches were used to determine the RNA virome of Culex mosquitoes collected in Ishikawa Prefecture, Japan. The identification of blood meal sources from wild-caught Culex spp. revealed that Culex (Culex) tritaeniorhynchus Giles, 1901, has a robust preference toward wild boar (62%, 26/42), followed by heron (21%, 9/42). The other two species, Culex (Oculeomyia) bitaeniorhynchus Giles, 1901, and Culex (Culex) orientalis Edwards, 1921, showed a distinct preference for avian species, including migratory birds. From the HTS results, 34 virus sequences were detected, four of which were newly identified virus sequences of unclassified Aspiviridae, Qinviridae, Iflaviridae, and Picornaviridae. The absence of observable cytopathic effects in mammalian cells and phylogenetic analysis suggested that all identified virus sequences were insect-specific. Further investigations involving other mosquito populations collected in different areas are warranted to explore previously unknown vertebrate hosts that may be linked to JEV dispersal in nature.
Democratic Stakeholder Representativeness
Authors: Jastram Sarah Margaretha , Berberyan Zara
Published: April 2023

Stakeholder theory has been advocating the inclusion of affected parties in organizational processes to increase the legitimacy and effectiveness of organizational governance. However, organizations can fail to achieve these objectives if there is no systematic link between stakeholders and their constituency. Based on democratic notions of representation, we argue that democratic stakeholder representativeness is an essential virtue of stakeholder governance processes. We conceptually derive authorization and accountability as normative elements of stakeholder representativeness and operationalize the construct by proposing empirical indicators of stakeholder representativeness as well as procedural guidance on their adoption in a practical governance context. By doing so, we contribute to the advancement of practical stakeholder governance as well as to the public management and organizational theory literature by specifying and operationalizing a construct that had previously been only vaguely defined.
The pleiotropic effects of statins in rheumatoid arthritis
Authors: Aminifar Elham , Tavakkol Afshari Haleh Sadat , Sathyapalan Thozhukat , Abbasifard Mitra , Sahebkar Amirhossein
Published: April 2023

Objectives

Rheumatoid arthritis (RA) is an inflammatory and autoimmune disease. Studies over the past two decades suggest that statins have a beneficial impact on the complications associated with RA. These complications include RA disease activity and risk for cardiovascular diseases (CVD). This review aims to discuss the efficacy of statin therapy in RA.

Key findings

The current evidence suggests that statins' immunomodulatory and antioxidant properties significantly reduce disease activity and inflammatory response in patients with RA. In RA patients, the risk of CVD is reduced by statin treatment, and statin discontinuation is associated with an increased cardiovascular disease risk.

The combined effect of statins on improving vascular function, lowering lipid levels, and reducing inflammation in RA patients is responsible for the decreased all-cause mortality in statin users. Further clinical studies are needed to ensure the therapeutic efficacy of statins in patients with RA.
Astronomical seeing and wind speed distributions with ERA5 data at Lenghu site on the Tibetan Plateau
Authors: Zhu Liming , Zhang Hanjiu , Sun Gang , Li Xuebin , Yang Fan , He Fei , Weng Ningquan , Deng Licai
Published: April 2023

In this paper, we present comprehensive night-time seeing statistics at the Lenghu site using data collected between 2018 and 2021 using a differential image motion monitor. The results show that the median seeing is 0.80 arcsec, which slightly larger than that previously reported due to climate change. Additionally, we investigated the annual, seasonal, and monthly seeing statistics, as well as possible hourly seeing trends in each season. The results demonstrate that the seeing at the Lenghu site is very stable, with monthly median seeing varying from 0.6 to 0.95 arcsec. The seasonal dependence of seeing shows obvious variations over different years. The best year of seeing was 2019 (0.74 arcsec), and the best seeing occurred in spring (0.68 arcsec) to early summer (June, 0.63 arcsec), while the worst seeing occurred in winter (0.80 arcsec). The minimum seeing value throughout the night is at approximately three hours before dawn. Furthermore, wind speed profiles, especially V200 (particularly the wind speed at 200 mbar), are important parameters for evaluating astronomical sites in terms of their suitability for adaptive optics. We first show the complete monthly average behaviours of the wind speed profile and V200 using the European Center for Medium-Range Weather Forecast reanalysis data sets. The results demonstrate the annual periodicity and variability of V200, and the yearly V200 modulation function is also provided. V200 maintains large values throughout the autumn (average: 35.01 m s−1) and winter (average: 34.33 m s−1), while the minimum V200 occurs in spring (average: 27.93 m s−1).
Modelling the cosmological Lyman–Werner background radiation field in the early Universe
Authors: Incatasciato Andrea , Khochfar Sadegh , Oñorbe Jose
Published: April 2023

The Lyman–Werner (LW) radiation field is a key ingredient in the chemothermal evolution of gas in the early Universe, as it dissociates H2 molecules, the primary cooling channel in an environment devoid of metals and dust. Despite its important role, it is still not implemented in cosmological simulations on a regular basis, in contrast to the ionizing UV background. This is in part due to uncertainty in the source modelling, their spectra and abundance, as well as the detailed physics involved in the propagation of the photons and their interactions with the molecules. The goal of this work is to produce an accurate model of the LW radiation field at z ≥ 6, by post-processing the physics-rich high-resolution FiBY simulation. Our novelties include updated cross-sections for H2, $\rm {H^-}$ and $\rm {H^+_2}$ chemical species, IGM absorption by neutral Hydrogen and various spectral models for Population III and Population II stars. With our fiducial set of parameters, we show that the mean LW intensity steadily increases by three orders of magnitude from z ∼ 23 to z ∼ 6, while spatial inhomogeneities originate from massive star-forming galaxies that dominate the photon budget up to a distance of ∼100 proper kpc. Our model can be easily applied to other simulations or semi-analytical models as an external radiation field that regulates the formation of stars and massive black hole seeds in high-z low-mass haloes.
The large-scale structure of globular clusters in the NGC 1052 group
Authors: Buzzo Maria Luisa , Forbes Duncan A , Brodie Jean P , Janssens Steven R , Couch Warrick J , Romanowsky Aaron J , Gannon Jonah S
Published: April 2023

Prompted by the many controversial claims involving the NGC 1052 group, including that it hosts two dark matter-free galaxies with overluminous and monochromatic globular cluster (GC) systems, here, we map out the large-scale structure (LSS) of GCs over the entire group. To recover the LSS, we use archival optical CFHT imaging data. We recover two GC density maps, one based on universal photometric properties of GCs from simple stellar population models, and one based on the properties of spectroscopically confirmed GCs in DF2 and DF4 (the two dwarf galaxies with overluminous GC populations). Both selection methods reveal overdensities around the massive galaxies in the group, as well as around NGC 1052 itself, that are coincident with the positions of previously identified stellar streams and tidal features. No intragroup GCs are found connecting these structures to any of the dwarf galaxies. We find, however, two other dwarfs in the group hosting GC systems. These include RCP32 with two GCs with ages equivalent to the GCs around NGC 1052 and DF9 with three GCs with ages similar to the GCs around DF2 and DF4. We conclude that the GC distribution in the group does not strongly support any formation scenario in particular. It favours, none the less, scenarios relying on galaxy–galaxy interactions and on the coeval formation of GCs around the DM-free dwarf galaxies. These may include the recently proposed bullet-dwarf formation, as well as high-redshift tidal dwarf galaxy models.
Assessing stellar yields in Galaxy chemical evolution: Observational stellar abundance patterns
Authors: Liang Jinning , Gjergo Eda , Fan XiLong
Published: April 2023

One-zone Galactic chemical evolution (GCE) models have provided useful insights on a great wealth of average abundance patterns in many environments, especially for the Milky Way and its satellites. However, the scatter of such abundance patterns is still a challenging aspect to reproduce. The leading hypothesis is that dynamics is a likely major source of the dispersion. In this work, we test another hypothesis, namely, that different assumptions on yield modelling may be at play simultaneously. We compare whether the abundance patterns spanned by the models are consistent with those observed in Galactic data. First, we test the performance of recent yield tabulations, and show which of these tabulations best fit Galactic stellar abundances. We then group the models and test if yield combinations match the data scatter and standard deviation. On a fixed Milky Way-like parametrization of NuPyCEE, we test a selection of yields for the three dominant yield sets: low-to-intermediate mass stars, massive stars, and Type Ia supernovae. We also include the production of r-process elements by neutron star mergers. We explore the statistical properties spanned by such yields. We identify the differences and commonalities among yield sets. We define criteria that estimate whether an element is in agreement with the data, or if the model overestimates or underestimates it in various redshift bins. While it is true that yields are a major source of uncertainty in GCE models, the scatter of abundances in stellar spectra cannot be explained by a simple averaging of runs across yield prescriptions.
uGMRT observations of the hot-Saturn WASP-69b: Radio-Loud Exoplanet–Exomoon Survey II (RLEES II)
Authors: Narang Mayank , Oza Apurva V , Hakim Kaustubh , Manoj P , Tyagi Himanshu , Banerjee Bihan , Surya Arun , Nayak Prasanta K , Banyal Ravinder K , Thorngren Daniel P
Published: April 2023

Exomoons have so far eluded ongoing searches. Several studies have exploited transit and transit timing variations and high-resolution spectroscopy to identify potential exomoon candidates. One method of detecting and confirming these exomoons is to search for signals of planet-moon interactions. In this work, we present the first radio observations of the exomoon candidate system WASP-69b. Based on the detection of alkali metals in the transmission spectra of WASP-69b, it was deduced that the system might be hosting an exomoon. WASP-69b is also one of the exoplanet systems that will be observed as part of JWST cycle-1 GTO. This makes the system an excellent target to observe and follow up. We observed the system for 32 h at 150 and 218 MHz using the upgraded Giant Metrewave Radio Telescope (uGMRT). Though we do not detect radio emission from the systems, we place strong 3σ upper limits of 3.3 mJy at 150 MHz and 0.9 mJy at 218 MHz. We then use these upper limits to estimate the maximum mass-loss from the exomoon candidate.
Pulse profile modelling of thermonuclear burst oscillations − I. The effect of neglecting variability
Authors: Kini Yves , Salmi Tuomo , Watts Anna L , Vinciguerra Serena , Choudhury Devarshi , Fenne Siem , Bogdanov Slavko , Meisel Zach , Suleimanov Valery
Published: April 2023

We study the effects of the time-variable properties of thermonuclear X-ray bursts on modelling their millisecond-period burst oscillations. We apply the pulse profile modelling technique that is being used in the analysis of rotation-powered millisecond pulsars by the Neutron Star Interior Composition Explorer to infer masses, radii, and geometric parameters of neutron stars. By simulating and analysing a large set of models, we show that overlooking burst time-scale variability in temperatures and sizes of the hot emitting regions can result in substantial bias in the inferred mass and radius. To adequately infer neutron star properties, it is essential to develop a model for the time-variable properties or invest a substantial amount of computational time in segmenting the data into non-varying pieces. We discuss prospects for constraints from proposed future X-ray telescopes.
Cosmological constraints from galaxy clusters and groups in the eROSITA final equatorial depth survey
Authors: Chiu I-Non , Klein Matthias , Mohr Joseph , Bocquet Sebastian
Published: April 2023

We present the first cosmological study of a sample of eROSITA clusters, which were identified in the eROSITA Final Equatorial Depth Survey (eFEDS). In a joint selection on X-ray and optical observables, the sample contains 455 clusters within a redshift range of 0.1 < z < 1.2, of which 177 systems are covered by the public data from the Hyper Suprime-Cam (HSC) survey that enables uniform weak-lensing cluster mass constraints. With minimal assumptions, at each cluster redshift we empirically model (1) the scaling relations between the cluster halo mass and the observables, which include the X-ray count rate, the optical richness, and the weak-lensing mass, and (2) the X-ray selection in terms of the completeness function $\mathcal {C}$. Using the richness distribution of the clusters, we directly measure the X-ray completeness and adopt those measurements as informative priors for the parameters of $\mathcal {C}$. In a blinded analysis, we obtain the cosmological constraints $\Omega _{\mathrm{m}}= 0.245^{+0.048}_{-0.058}$, $\sigma _{8}= 0.833^{+0.075}_{-0.063}$, and $S_{8}\equiv \sigma _{8}\left(\Omega _{\mathrm{m}}/0.3\right)^{0.3}= 0.791^{+0.028}_{-0.031}$ in a flat ΛCDM cosmology. Extending to a flat wCDM cosmology leads to the constraint on the equation of state parameter of the dark energy of w = −1.25 ± 0.47. The eFEDS constraints are in good agreement with the results from the Planck mission, the galaxy–galaxy lensing and clustering analysis of the Dark Energy Survey, and the cluster abundance analysis of the SPT-SZ survey at a level of ≲ 1σ. With the empirical modelling, this work presents the first fully self-consistent cosmological constraints based on a synergy between wide-field X-ray and weak lensing surveys.
Multi-wavelength aperture polarimetry of debris disc host stars
Authors: Marshall Jonathan P , Cotton Daniel V , Bott Kimberly , Bailey Jeremy , Kedziora-Chudczer Lucyna , Brown Emma L
Published: April 2023

Debris discs around main sequence stars have been extensively characterized from infrared to millimetre wavelengths through imaging, spectroscopic, and total intensity (scattered light and/or thermal emission) measurements. Polarimetric observations have only been used sparingly to interpret the composition, structure, and size of dust grains in these discs. Here, we present new multiwavelength aperture polarization observations with parts-per-million sensitivity of a sample of twelve bright debris discs, spanning a broad range of host star spectral types, and disc properties. These measurements were mostly taken with the HIgh Precision Polarimetric Instrument on the Anglo-Australian Telescope. We combine these polarization observations with the known disc architectures and geometries of the discs to interpret the measurements. We detect significant polarization attributable to circumstellar dust from HD 377 and HD 39060, and find tentative evidence for HD 188228 and HD 202628.
A search for thermal gyro-synchrotron emission from hot stellar coronae
Authors: Golay Walter W , Mutel Robert L , Lipman Dani , Güdel Manuel
Published: April 2023

We searched for thermal gyro-synchrotron radio emission from a sample of five radio-loud stars whose X-ray coronae contain a hot ($T_e\gt 10^7\,$K) thermal component. We used the JVLA to measure Stokes I and V/I spectral energy distributions (SEDs) over the frequency range 15 – 45 GHz, determining the best-fitting model parameters using power-law and thermal gyro-synchrotron emission models. The SEDs of the three chromospherically active binaries (Algol, UX Arietis, HR 1099) were well-fit by a power-law gyro-synchrotron model, with no evidence for a thermal component. However, the SEDs of the two weak-lined T Tauri stars (V410 Tau, HD 283572) had a circularly polarized enhancement above 30 GHz that was inconsistent with a pure power-law distribution. These spectra were well-fit by summing the emission from an extended coronal volume of power-law gyro-synchrotron emission and a smaller region with thermal plasma and a much stronger magnetic field emitting thermal gyro-synchrotron radiation. We used Bayesian inference to estimate the physical plasma parameters of the emission regions (characteristic size, electron density, temperature, power-law index, and magnetic field strength and direction) using independently measured radio sizes, X-ray luminosities, and magnetic field strengths as priors, where available. The derived parameters were well-constrained but somewhat degenerate. The power-law and thermal volumes in the pre-main-sequence stars are probably not co-spatial, and we speculate they may arise from two distinct regions: a tangled-field magnetosphere where reconnection occurs and a recently discovered low-latitude poloidal magnetic field, respectively.
Why the observed spin evolution of older-than-solar-like stars might not require a dynamo mode change
Authors: Kotorashvili Ketevan , Blackman Eric G , Owen James E
Published: April 2023

The spin evolution of main-sequence stars has long been of interest for basic stellar evolution, stellar ageing, stellar activity, and consequent influence on companion planets. Observations of older-than-solar late-type main-sequence stars have been interpreted to imply that a change from a dipole-dominated magnetic field to one with more prominent higher multipoles might be necessary to account for the data. The spin-down models that lead to this inference are essentially tuned to the Sun. Here, we take a different approach that considers individual stars as fixed points rather than just the Sun. We use a time-dependent theoretical model to solve for the spin evolution of low-mass main-sequence stars that includes a Parker-type wind and a time-evolving magnetic field coupled to the spin. Because the wind is exponentially sensitive to the stellar mass over radius and the coronal base temperature, the use of each observed star as a separate fixed point is more appropriate and, in turn, produces a set of solution curves that produces a solution envelope rather than a simple line. This envelope of solution curves, unlike a single line fit, is consistent with the data and does not unambiguously require a modal transition in the magnetic field to explain it.
Getting in shape with minimal energy: a variational principle for protohaloes
Authors: Musso Marcello , Sheth Ravi K
Published: April 2023

In analytical models of structure formation, protohaloes are routinely assumed to be peaks of the smoothed initial density field, with the smoothing filter being spherically symmetric. This works reasonably well to identify a protohalo’s centre of mass, but not its shape. To provide a more realistic description of protohalo boundaries, one must go beyond the spherical picture. We suggest that this can be done by looking for regions of fixed volume, but arbitrary shape, that minimize the enclosed energy. Such regions are delimited by surfaces over which (a slightly modified version of) the gravitational potential is constant. We show that these equipotential surfaces provide an excellent description of protohalo shapes, orientations, and associated torques.
exFINDER: identify external communication signals using single-cell transcriptomics data
Authors: He Changhan , Zhou Peijie , Nie Qing
Published: April 2023

Cells make decisions through their communication with other cells and receiving signals from their environment. Using single-cell transcriptomics, computational tools have been developed to infer cell–cell communication through ligands and receptors. However, the existing methods only deal with signals sent by the measured cells in the data, the received signals from the external system are missing in the inference. Here, we present exFINDER, a method that identifies such external signals received by the cells in the single-cell transcriptomics datasets by utilizing the prior knowledge of signaling pathways. In particular, exFINDER can uncover external signals that activate the given target genes, infer the external signal-target signaling network (exSigNet), and perform quantitative analysis on exSigNets. The applications of exFINDER to scRNA-seq datasets from different species demonstrate the accuracy and robustness of identifying external signals, revealing critical transition-related signaling activities, inferring critical external signals and targets, clustering signal-target paths, and evaluating relevant biological events. Overall, exFINDER can be applied to scRNA-seq data to reveal the external signal-associated activities and maybe novel cells that send such signals.
Dietary pattern, food, and nutritional supplement effects on cognitive outcomes in mild cognitive impairment: a systematic review of previous reviews
Authors: Andrews Victoria , Zammit Gabrielle , O’Leary Fiona
Published: April 2023

Context

Nutritional interventions may benefit cognition in people with mild cognitive impairment (MCI). However, evidence is yet to be synthesized in a way that can inform recommendations for clinical and public health settings.

Objective

To systematically review evidence on the effect of dietary patterns, foods, and nutritional supplements on cognitive decline in individuals with MCI.

Data Sources

Guided by the Preferred Reporting items for Systematic Review and Meta-Analysis Protocols 2015 statement, the Medline, EMBASE, and CINAHL databases, the JBI Database of Systematic Reviews and Implementation Reports, Cochrane Database of Systematic Reviews, and Database of Abstracts of Reviews of Effects were searched (publication years 2005 to 2020). Included studies were English-language systematic reviews and meta-analyses of randomized controlled trials and cohort studies reporting on the effectiveness of nutritional interventions on cognition of individuals with MCI.

Data Extraction

Two reviewers independently selected studies and extracted data on cognitive outcomes and adverse events. Review quality was assessed using AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews–2). Primary study overlap was managed following Cochrane Handbook guidelines.

Data Analysis

Of the 6677 records retrieved, 20 reviews were included, which, in turn, reported on 43 randomized controlled trials and 1 cohort study that, together, addressed 18 nutritional interventions. Most reviews were limited by quality and the small number of primary studies with small sample sizes. Reviews were mostly positive for B vitamins, omega-3 fatty acids, and probiotics (including 12, 11 and 4 primary studies, respectively). Souvenaid and the Mediterranean diet reduced cognitive decline or Alzheimer’s disease progression in single trials with <500 participants. Findings from studies with a small number of participants suggest vitamin D, a low-carbohydrate diet, medium-chain triglycerides, blueberries, grape juice, cocoa flavanols, and Brazil nuts may improve individual cognitive subdomains, but more studies are needed.

Conclusions

Few nutritional interventions were found to convincingly improve cognition of individuals with MCI. More high-quality research in MCI populations is required to determine if nutritional treatments improve cognition and/or reduce progression to dementia.

Systematic review registration

Open Science Framework protocol identifier DOI:10.17605/OSF.IO/BEP2S.
External Validity of Two Scores for Predicting the Risk of Chemotherapy Toxicity Among Older Patients With Solid Tumors: Results From the ELCAPA Prospective Cohort
Authors: Frelaut Maxime , Paillaud Elena , Beinse Guillaume , Scain Anne-Laure , Culine Stéphane , Tournigand Christophe , Poisson Johanne , Bastuji-Garin Sylvie , Canoui-Poitrine Florence , Caillet Philippe
Published: April 2023

Background

Severe chemotherapy-related toxicities are frequent among older patients. The Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) and the Cancer and Aging Research Group Study (CARG) score were both developed to predict these events.

Patients and Methods

The objective of this study was to evaluate the scores’ predictive performance in a prospective cohort, which included patients aged 70 years and older referred for a geriatric assessment prior to chemotherapy for a solid tumor. The main endpoints were grades 3/4/5 toxicities for the CARG score and grades 4/5 hematologic toxicities and grades 3/4/5 non-hematologic toxicities for the CRASH score.

Results

A total of 248 patients were included, of which 150 (61%) and 126 (51%) experienced at least one severe adverse event as defined respectively in CARG and CRASH studies. The incidence of adverse events was not significantly greater in the intermediate and high-risk CARG groups than in the low-risk group (odds ratio (OR) [95% CI] = 0.3 [0.1-1.4] (P = .1) and 0.4 [0.1-1.7], respectively). The area under curve (AUC) was 0.55. Similarly, the incidence of severe toxicities was no greater in the intermediate-low, intermediate-high, and high-risk CRASH groups than in the low-risk CRASH group (OR [95%CI] = 1 [0.3-3.6], 1 [0.3-3.4], and 1.5 [0.3-8.1], respectively). The AUC was 0.52. The type of cancer, performance status, comorbidities, body mass index, and MAX2 index were independently associated with grades 3/4/5 toxicities.

Conclusion

In an external cohort of older patients referred for a pretherapeutic GA, the CARG and CRASH scores were poor predictors of the risk of chemotherapy severe toxicities.
Bipolar Androgen Therapy Followed by Androgen Receptor Inhibition as Sequential Therapy for Prostate Cancer
Authors: Denmeade Samuel R , Sena Laura A , Wang Hao , Antonarakis Emmanuel S , Markowski Mark C
Published: April 2023

Inhibition of androgen receptor (AR) signaling has been the mainstay of treatment of advanced prostate cancer (PCa) for the past 80 years. Combination and sequential AR-inhibiting therapies are highly effective palliative therapy, but they are not curative. All patients eventually develop resistance to primary castrating therapy [ie, castration-resistant PCa (CRPC)]. At this point, they are treated with subsequent lines of secondary AR inhibitory therapies. However, resistance to these agents also develops and patients progress to a state we have termed complete androgen inhibition-resistant PCa. This phase of the disease is associated with poor prognosis. At this point, treatment shifts to non-hormonal cytotoxic therapies (eg, chemotherapy and radiopharmaceuticals). However, the majority of PCas remain addicted to signaling through AR throughout the course of the disease. Resistant PCa cells adaptively upregulate AR activity, despite castration and AR inhibitors, via mechanisms such as AR overexpression, gene amplification, mutation, and expression of ligand-independent variants to permit sustained liganded and non-liganded AR signaling. Studies dating back nearly 30 years indicate that high expression of AR induced by prolonged castration becomes a vulnerability of CRPC cells in vitro and in mouse xenografts to supraphysiologic androgen (SPA), which induces cell death and growth arrest in this context. Based on these studies, we developed a counterintuitive treatment called bipolar androgen therapy (BAT) for patients with CRPC, in which SPA is administered intermittently to result in cycling of serum testosterone from the polar extremes of supraphysiologic to near-castrate levels. This rapid cycling is intended to disrupt the adaptive of AR regulation associated with chronic exposure to high or low levels of testosterone, while simultaneously targeting the spectrum of AR expression present in heterogeneous CRPC tumors. We have now tested BAT in >250 patients with CRPC. Here we present a review of these clinical studies, which have demonstrated collectively that BAT can be safely given to men with CRPC, improves quality of life, and produces therapeutic responses in ~30% of patients. As expected, resistance to BAT is associated with adaptive downregulation of AR expression. Intriguingly, this downregulation is associated with restoration of sensitivity to subsequent AR inhibitor therapies.