bluuebunny/crossref_metadata_2025 huggingface dataset:
SAÚDE DA CRIANÇA: Experiências adversas na infância e o seu impacto no desenvolvimento da vida adulta
Authors: Silva Ana Paula de Siqueira , Lima Dayane Chaves de , Ribeiro Jessica Dias
Published: December 2024

Prezados autores, esta pesquisa buscou apresentar informações da literatura com relação as experiências adversas adquiridas na infância e seu impacto na vida adulta, a fim de identificar na literatura o processo de construção e desenvolvimento do indivíduo adulto a partir do impacto gerado pelas Experiências Adversas adquiridas na infância. Para isso, esta obra trata de uma revisão integrativa de literatura, através dessa sistematização foi possível coletar novas informações sobre a temática proposta para obter as informações necessárias para realização da pesquisa.
Entre os principais achados, destaca-se que foi possível detectar as consequências derivadas das adversidades da infância na vida adulta no qual predominou as doenças psicológicas com 41% da amostra, seguido das consequências sistêmicas com 23% e em empate com as consequências hormonais que apresentaram um índice de 23%. Posteriormente a diminuição de capacidade e clareza retratou 7% e, por fim, as doenças cardiovasculares, hipertensão arterial e supressão e dificuldade de repressão em consonância onde cada uma apresentou 6% da amostra.
Ademais, os sinais e os sintomas perceptíveis mais mencionados estão com o mesmo índice, sendo eles ansiedade, estresse e depressão obtendo 30% da amostra em cada fator pesquisado. Entretanto foi possível identificar outro fator, porém apresentou apenas 10% da amostra, sendo ele a ideação suicida. Perante o exposto, e por meio da intensificação do estudo, foi possível evidenciar as influências que as adversidades na infância proporcionam mediante ao comportamento social, tendo destaque o abuso de bebidas alcóolicas com 37% da amostra possuindo a mesma relação com o índice do abuso de substâncias ilícitas que obteve 37% da amostra.
Além desses outros comportamentos foram identificadas outras condutas, sendo elas atividades criminosas e conduta sexual agressiva com, respectivamente, 13% dos resultados. Portanto, o conceito de saúde engloba várias esferas e não se limita somente em doenças físicas, mas também em doenças psicológicas que prejudicam de várias formas a saúde de uma pessoa. Ainda por cima, mediante ao desenvolvimento e resultados percebe-se que as consequências não se limitam apenas à rede da saúde, mas também ao âmbito social, ao desenvolvimento profissional e estudantil, trazendo problemas de saúde pública a problemas sociais e econômicos.
OS PRINCÍPIOS FUNDAMENTAIS DA REPÚBLICA FEDERATIVA DO BRASIL
Authors: Loiola Gleydson Siqueira
Published: December 2024

O trabalho traz como temática “Os Princípios Fundamentais da República Federativa do Brasil”. Estes princípios estão previstos constitucionalmente, e, em virtude deles, é que se tem um Estado Democrático de Direito baseado em direitos humanos, em garantias individuais e coletivas, em igualdade, em solidariedade, em respeito ao próximo, e em uma sociedade livre, justa, pluralista e pacífica, dentre outras formas de uma visão de bem estar humano, social e justo. A pesquisa tem como objetivo geral analisar esses princípios em uma ótica constitucional, compreendendo-se como se efetuam direta, ou, indiretamente, na vida de cada uma das pessoas residentes, ou, não, na República Federativa do Brasil, de modo a podermos refletir sobre as consequências, desdobramentos, gerados apartir da sua aplicação por meio das diversas políticas públicas, através do nosso ordenamento jurídico pátrio, em nossa sociedade, pelos nossos governantes. Quanto a forma da pesquisa, trata-se de pesquisa qualitativa, tendo como método o dedutivo e de procedimento técnico bibliográfico e documental. Como será analisado na pesquisa, é garantido à aplicação deles(os princípios) ao máximo possível em nossa sociedade brasileira, através de mecanismos constitucionais, pelas nossas autoridades, tendo previsão constitucional a sua fiscalização, execução, e adequação ao caso concreto em possíveis conflitos entre eles.
Unveiling Spectatorship: Exploring Audience Engagement and Cultural Discourses in Hamlet's 'Mousetrap' and Haider's 'Bismil’
Authors: Jaffar Nosheen , Mohammed Lubna Ali , Saleem Muhammad
Published: December 2024

This study investigates the dynamic interplay of spectatorship and performance in Vishal Bhardwaj's Haider and Shakespeare's Hamlet, focusing on the concept of the play-within-the-play to explore intersecting political and cultural discourses. In Hamlet, the “Mousetrap” scene serves as a pivotal metatheatrical moment that reveals hidden truths and assigns guilt, drawing the audience into a profound examination of justice and morality. By contrast, Haider reimagines this metatheatrical device through the “Bismil” sequence, an act of political resistance set against the fraught socio-political landscape of Kashmir. Bhardwaj transforms Shakespeare's classic into a critique of political oppression, aligning it with postcolonial concerns and regional narratives. This adaptation actively subverts Western cultural dominance, urging audiences to engage critically with both the source text and its recontextualized meanings. Situating Haider within a broader tradition of audience-centric reinterpretations of Hamlet, the study highlights how Bollywood melodrama reshapes Shakespearean drama’s emotional and analytical dimensions. The use of music, dance, and symbolism in Haider intensifies its political resonance, making the “Bismil” sequence not just a narrative device but a powerful critique of systemic violence. By emphasizing metatheatrical elements, this paper explores their role in advancing political commentary, fostering cultural hybridization, and disrupting dominant narratives. Ultimately, Haider exemplifies the transformative potential of adaptations, revealing how they can deepen audience engagement and broaden the political scope of classic texts, illuminating new possibilities for resistance and critique within contemporary frameworks.
Long Term Variability of Extreme Sea Surface Temperature in the Gulf of Tonkin, China
Authors: Yichun Lin  , Osinowo Adekunle
Published: December 2024

Till date, no study on trends in extreme sea surface temperature (SST) for different return periods has been done over the Gulf of Tonkin (GoT). Based on a 84-year (1940-2023) ERA5 Reanalysis data sets, this study for the first time, examined the spatio-temporal pattern in extreme SST for different return periods. Findings showed that more significant moderate to fast warming trends (0.1-0.16 °C per decade (dec-1)) only existed for the 2 year return period. Temporal trends in the 99th percentile SST are insignificant for all return periods. By using the linear regression method, the variability in extreme SST was obtained. Results showed that moderate warming trends dominated a large portion of GoT. Stronger trends, up to 0.018°C yr-1 are noticed near Guangdong, Haikou and southern Sanya in south China. Extreme SST exhibited a slow warming trend of 0.008 °C per year (yr-1) all through the study years. The SST is most stable in most waters in the southern GoT and few waters surrounding Dongfang. Temporal warming rates of SST revealed that 1940-1958, 1976-1994 and 2003-2012 were years of more coastal upwelling and could affect aquatic lives. The strongest warming rate of 0.07°C dec-1 occurred during 1994-2003. The GoT appeared warmer during spring. Spatial decadal variability of SST revealed that moderate warming trends occurred in few regions in the southern GoT and in larger portion of the central and northern GoT. The rise in SST between 1980 and 2020 in the GoT is not limited to increased anthropogenic activities.
From mechanisms to application: Exploring Pickering emulsions stabilized by nanocellulose with eucalyptus oil for enhanced seed germination
Authors: Dhaval B Kadam  , Vinaykumar J Barai  , Swapnaja R Kamble  , Nikhil P Powale  , Dipali S Raut  , Guruprasad R Mavlankar  , Prajkta P Baikar  , Deepa S Rangdal  , Minakshi N. Bhatu  , Shubhangi P Patil
Published: December 2024

This study comprehensively explores Pickering emulsions, their stabilization mechanisms, and the potential of nanocellulose in agricultural applications. Initially, the fundamental principles and mechanisms of Pickering emulsions are reviewed, highlighting their ability to form stable, particle-stabilized emulsions. The focus then shifts to cellulose nanocrystals (CNCs), extracted from sugarcane bagasse, as stabilizing agents in emulsions containing eucalyptus oil, with the aim of enhancing seed germination in mung beans. CNCs were characterized using X-ray diffraction (XRD), infrared spectroscopy (IR), and scanning electron microscopy (SEM), confirming their suitability for forming stable emulsions. Results demonstrate that CNC-stabilized Pickering emulsions with eucalyptus oil create a conducive microenvironment for seed germination, offering an eco-friendly and sustainable agricultural innovation. The utilization of sugarcane bagasse-derived CNCs emphasizes the valorization of agricultural waste, aligning with principles of circular economy and sustainability. While the findings are promising, further research is needed to elucidate the mechanisms by which CNC-stabilized emulsions enhance germination, evaluate their broader applicability to other crops, and examine long-term effects on plant growth and development. This work bridges fundamental research on Pickering emulsions and practical applications, showcasing the potential of nanotechnology and agricultural waste valorization in driving sustainable agricultural practices.
Smart agriculture as a driving technology for sustainability in intensive greenhouse production within smart manufacturing systems
Authors: Shuvo Kumar Mallik  , M Abeedur Rahman
Published: December 2024

This essay investigates the link between smart agriculture and sustainability in the context of intensive greenhouse farming in Bangladesh. This qualitative data analysis combines a literature review with expert interviews to acquire a full picture of the topic under inquiry. The findings highlight three key areas of technology that have a big impact on this type of agriculture. The first category concentrates on soil and water conservation, sensor utilization, and environmental enhancement. The second group focuses on robot utilization, labor reduction, cost reductions, and economic sustainability. Finally, the third group considers economic sustainability. In summary, smart agriculture is expected to improve economic and environmental sustainability while reducing the social dimension to a remote level. The imbalance suggests that immediate benefits may take precedence over social and ethical considerations. Future investments may lead to polarization.
Future cities and sustainable development: Integrating renewable energy, advanced materials, and civil engineering for urban resilience
Authors: Rasheed O. Ajirotutu  , Abiodun Benedict Adeyemi  , Gil-Ozoudeh Ifechukwu  , Obinna Iwuanyanwu  , Tochi Chimaobi Ohakawa  , Baalah Matthew Patrick Garba
Published: December 2024

This review focuses on the integration of renewable energy, advanced materials, and civil engineering to foster urban resilience in future cities. As urban populations continue to grow, the demand for sustainable solutions to mitigate environmental impact and enhance quality of life becomes increasingly urgent. This review explores how the convergence of renewable energy sources, innovative materials, and civil engineering practices can contribute to the development of resilient cities capable of meeting the challenges of the 21st century. The integration of renewable energy sources, such as solar, wind, and hydroelectric power, offers opportunities to reduce dependence on fossil fuels and mitigate greenhouse gas emissions. Advancements in renewable energy technologies allow for the generation of clean, reliable energy within urban environments, promoting energy independence and reducing carbon footprints. Additionally, the utilization of advanced materials in urban infrastructure can enhance durability, efficiency, and sustainability. Nanotechnology, for example, enables the development of high-performance materials with superior strength, flexibility, and resilience. These materials can be used in construction, transportation, and water management systems to improve infrastructure resilience and longevity. Furthermore, civil engineering plays a crucial role in designing and implementing sustainable urban infrastructure. From green building practices to resilient urban planning, civil engineers are instrumental in creating cities that can withstand environmental hazards and adapt to changing conditions. By integrating renewable energy, advanced materials, and innovative engineering solutions, cities can enhance their resilience to climate change, natural disasters, and other challenges. This review examines case studies and examples of successful integration of renewable energy, advanced materials, and civil engineering in urban development projects worldwide. It also discusses the challenges and opportunities associated with implementing these solutions, including technological barriers, financial considerations, and policy frameworks. The integration of renewable energy, advanced materials, and civil engineering is essential for building resilient and sustainable cities of the future. By embracing innovation and collaboration across disciplines, cities can enhance their capacity to thrive in the face of environmental, social, and economic challenges, ultimately improving the quality of life for urban residents while preserving the planet for future generations.
Use of waste clay brick powder as a partial replacement binder in geo-polymer concrete
Authors: Pallavi Prasanth Kartha
Published: December 2024

Geopolymer concrete is gaining as a sustainable alternative to traditional concrete due to its lower carbon footprint and use of industrial by-products. This study thoroughly examines the effectiveness of incorporating waste clay brick as a partial replacement binder in geopolymer concrete, specifically aiming to reduce environmental impact and improve mechanical and durability properties. Various geopolymer concrete formulations were methodically developed, with the inclusion of waste clay brick as a supplementary binder material at different replacement levels. Compressive strength, flexural strength, and split tensile strength exhibit promising results, with certain mix proportions showing enhanced performance compared to the control mix. Based on waste clay brick samples tested, the compressive strengths for both 20% and 30% binder samples remained between 25 MPa and 27 MPa. The flexural strength and the split tensile strength of the binder specimens showed nearly maximum higher strength. The reduction in water absorption also signifies enhanced long-term durability which was found to have 2 – 3%. Compared to GPC, the binder proportions investigated here showed much higher strength. Using 30% of the waste clay brick as a partial replacement binder in geopolymer concrete presents a promising avenue for sustainable construction practices.
Data analysis and model development for sulphate attack strength loss index in Chikoko blended concrete
Authors: Overo Kenneth Ejukonemu  , Joshua Odudu
Published: December 2024

Sulphate attack poses a significant durability challenge for concrete, particularly in environments with high sulphate concentrations. This study explores the efficacy of Chikoko, a natural pozzolan from the Niger Delta region, as a supplementary cementitious material to enhance concrete's sulphate resistance. The objective is to develop a predictive model for the strength loss index (SLI) of Chikoko-blended concrete exposed to sulphate attack. Concrete samples incorporating various Chikoko contents (0%, 5%, 10%, 15%, 20%) were immersed in a 5% sodium sulphate solution for durations of 7, 21, 28, 90, and 120 days, and subjected to different calcination temperatures. Compressive strength tests were conducted, followed by data analysis using ANOVA and regression techniques to identify significant factors and construct the predictive model. Results reveal that Chikoko substantially enhances sulphate resistance, with a 20% Chikoko replacement demonstrating the least strength loss. The predictive model developed from this study accurately estimates the SLI, providing a valuable tool for engineers to design durable concrete structures in sulphate-rich environments. These findings suggest that Chikoko is an effective and sustainable supplementary cementitious material, contributing to improved concrete durability and performance in aggressive sulphate conditions.
Review on poultry automation using IoT and machine learning
Authors: Bindushree G T  , Sreedevi M T
Published: December 2024

The poultry industry is undergoing a transformative technological revolution through the strategic integration of Internet of Things (IoT) and Machine Learning (ML) technologies. This comprehensive review explores the current state of poultry automation, examining innovative approaches that leverage advanced sensor networks, data analytics, and intelligent algorithms to address critical challenges in agricultural productivity. By synthesizing emerging research, the paper demonstrates how IoT and ML technologies are revolutionizing poultry farming through enhanced environmental monitoring, predictive health management, and precision resource optimization. These technological interventions offer unprecedented insights into animal welfare, operational efficiency, and sustainable farming practices, enabling real-time tracking of physiological parameters, early disease detection, and intelligent decision-making frameworks. The review critically analyzes the potential of these technologies to transform traditional agricultural methods, highlighting their capacity to improve farm productivity, reduce manual labor, and implement more targeted and responsive management strategies. As global food security demands increasingly sophisticated agricultural solutions, the convergence of IoT and ML represents a pivotal advancement in creating more intelligent, efficient, and responsive poultry production systems.
High-performance near-memory processing architecture for data-intensive applications
Authors: Rashmitha Reddy Vuppunuthula
Published: December 2024

Near-memory processing (NMP) offers a transformative approach to computing architecture by positioning processing units close to memory, thereby reducing data transfer delays and minimizing energy consumption. This paper introduces an innovative NMP architecture designed to bridge the gap between data storage and computation, significantly enhancing system performance for data-intensive applications. By embedding processing elements directly within memory arrays, the proposed design achieves notable improvements in key performance metrics. Experimental results demonstrate a latency reduction of over 40%, with matrix multiplication latency decreasing from 120.5 ms in traditional architectures to 70.4 ms. Energy consumption is reduced by nearly 50%, with workloads like matrix multiplication showing a drop from 25.6 J to 12.8 J. Additionally, the architecture achieves throughput gains of up to 100%, as seen in data analytics workloads where throughput increases from 48.1 GOPS to 96.5 GOPS. These results emphasize the architecture's ability to enhance computational efficiency and scalability, making it particularly advantageous for applications in artificial intelligence, scientific research, and big data analytics. This study underscores the potential of NMP to redefine high-performance computing by restructuring traditional data processing paradigms.
AI and machine learning-driven optimization for physical design in advanced node semiconductors
Authors: Rashmitha Reddy Vuppunuthula
Published: December 2024

As semiconductor technology advances toward smaller nodes, optimizing physical design has become a critical challenge in achieving high performance, efficiency, and scalability. Traditional design methods often fall short of meeting the demands of advanced node technology due to their limited adaptability and efficiency. This paper explores artificial intelligence (AI) and machine learning (ML) techniques tailored for physical design optimization in advanced node semiconductors. By leveraging AI-driven algorithms, including deep learning, reinforcement learning, and hybrid models, this study aims to streamline critical design processes such as placement, routing, and power optimization. The results demonstrate that AI-driven methods significantly outperform traditional techniques, achieving improvements of 13.5% in area efficiency, with a utilization rate of 89.1%, and a total power reduction of 18.8%. Furthermore, signal integrity, measured by Signal-to-Noise Ratio (SNR), improves by 40.8%, reaching 21.4 dB, while routing congestion is reduced to 7.2%. These findings highlight the transformative potential of AI and ML methodologies in addressing the complexities of advanced node design, offering scalable, efficient, and high-performance solutions for modern semiconductor technologies.
Leveraging data analytics to optimize government interventions for homelessness, substance abuse, and mental health: A case study in evidence-based policy design
Authors: Lateef Olawale Fatai  , Olayinka Farouk Salau  , Lawrencia Yaa Kakra Gaisie  , Ken Muchira
Published: December 2024

Introduction: Vulnerable groups facing the overlapping challenges of homelessness, substance abuse, and mental health issues form intricate social systems that require thoughtful analytical methods. Systematic barriers’ existence significantly contributes to inefficient healthcare and social services leading to complex problems that require complex response solutions. To understand how all these issues are interlinked, it becomes important to use some advanced analytical tools to determine what impacts such populations.
Materials and Methods: A systematic review methodology was used, incorporating different methods of analysis for existing literature as well as empirical research. By adapting synthesis multiple types, it was possible to obtain useful information from interdisciplinary fields of research through the use of complex bibliometric analyses. We used rationalism paradigms in this process erecting a literature review and meta-analysis paradigms alongside comparative case study analysis. For improved evidence quality and to minimize research bias we undertook a thorough scrutiny of diverse databases. All of these factors were tried out on the participants.
Results: Statistical analysis on the study's findings highlighted the intricate link between structural risk factors and intervention strategies. These investigations eventually revealed that the problems are complex and require multifaceted and connecting approaches. More precisely, we focused at the impact contexts of technology-based interventions and determined the multifaceted relations between social conditions, technological advancements and health care results. Theoretical models were explored more closely in order to gain more insight into the processes that lead to marginalization.
Discussion: Results on the study's findings highlighted the intricate link between structural risk factors and intervention strategies. Having analyze showed that there are always deeper aspects of the problems that require a complex, concurrent approach. More precisely, this work involved a review of literature towards identifying contextual factors that influence the effectiveness of the given intervention and how social determinants, technological advancement, and healthcare interplay. In light of this, theoretical models were analysed more thoroughly to provide insight into the processes that contribute to marginalization.
Conclusion: Addressing such social issues requires having a strategy and using all the available information. Technological, social, and empirical approaches, which are inclusive in the delivery of services, have promising potential in transforming service delivery. Applying technology-based collectively, it is possible to make the social equality actual and improve the condition of people living in poor environments.
Effectiveness of in-stent restenosis treatment using drug-eluting stents, paclitaxel-coated balloons, and sirolimus-coated balloons in managing complications after PCI in atherosclerosis patients
Authors: Felicia Kristianti  , Abdul Khairul Rizki Purba
Published: December 2024

Introduction: Coronary artery disease (CAD) is one of the leading causes of death worldwide. One of the primary causes of CAD is atherosclerosis. One of the management strategies for atherosclerosis is Percutaneous Coronary Intervention (PCI) using drug-eluting stents (DES). This procedure involves the insertion of a catheter to place a stent that opens narrowed blood vessels due to plaque accumulation. However, this procedure may be repeated due to complications such as in-stent restenosis (ISR), which is the re-narrowing of the arterial lumen after stent placement, caused by intimal hyperplasia. Two endovascular interventions that can be options for treating ISR are re-implantation of a DES or the use of drug-coated balloons (DCB). DCB presents an alternative to re-stenting. There are two DCB treatment options: Paclitaxel Coated Balloon (PCB) and Sirolimus Coated Balloon (SCB), whose effectiveness will be compared.
Methods: This literature review is written as a result of various interrelated literature studies, supported by analytical discussions. Literature search sources used six databases namely PubMed, Web of Science, Scopus, CINAHL, Proquest, and Cochrane with published years 2014-2024. The types of studies included are full text articles, systematic review, meta-analysis, randomized controlled trials, and case-control study.
Summary: Both DCBs showed nearly identical angiographic courses with very low lumen narrowing in this high-risk group in the treatment of DES restenosis after 6 months. This is the first indication that SCB is as effective as the best-in-class PCB.
Correlation Between Serum CA-125 Levels and Age in Advanced-Stage Epithelial Ovarian Cancer Patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia (2021-2022)
Authors: Yunia Santi Assabila  , Puspa Wardhani  , Hari Nugroho
Published: December 2024

Ovarian cancer is a gynecological malignancy that originates in the ovaries. Symptoms of ovarian cancer often remain unnoticed in its early stages, leading to a diagnosis at an advanced stage. CA-125 is a widely recognized biomarker used in ovarian cancer for diagnosis, monitoring treatment response, and predicting prognosis. Research has shown that CA-125 levels can vary with age and are influenced by multiple biological factors, including hormonal changes and the progression of ovarian cancer. Age-related factors can influence CA-125 levels, which may affect the interpretation of such examination results. This study aims to determine the correlation between serum CA-125 levels and ages in advanced-stage epithelial ovarian cancer patients. This research is a retrospective study using the comparative analytic research method by taking the medical record data of epithelial ovarian cancer with advanced-stage patients treated in oncology clinic of Dr. Soetomo General Hospital Surabaya for January 1, 2021 – December 2022. Based on the analysis of 61 patient subjects categorized into three age groups, the median serum CA-125 levels for patients aged <40 years were 172.85 U/mL, for those aged 40-50 years the median was 261 U/mL, and for patients aged >50 years the median was 116.2 U/mL. The Kruskal-Wallis test (p-value) yielded a result of 0.518, indicating that there was no statistically significant relationship between serum CA-125 levels of patients and patients’ age (p = 0.518). In addition, there is no correlation between serum CA-125 levels and age in advanced-stage epithelial ovarian cancer patients at Dr. Soetomo General Hospital, Surabaya.
Deontological ethics as moderating the relationship between trust determinations and taxpayer intentions on taxpayer compliance
Authors: Ni Luh Gede Mahayu Dicriyani  , Ni Luh Putu Sandrya Dewi
Published: December 2024

Taxpayer compliance is influenced by the level of trust that arises from within each individual, thus showing obedience to their obligations as taxpayers. The purpose of this study was to examine the relationship between trust and taxpayer intentions on taxpayer compliance by moderating deontological ethics. The object of this research is MSME actors in Bali. The results showed that trust and intention had a significant effect on taxpayer compliance. The effect of trust is considered higher with a path coefficient (0.471) than intention (0.298), although intention is also still seen by respondents as providing benefits in encouraging compliance with tax obligations. The Deontological Ethics variable is considered to significantly moderate / strengthen the effect of trust and intention on Taxpayer Compliance. The higher and better the Deontology Ethics attitude grows in respondents, the stronger the influence of respondents' understanding of trust is higher (path coefficient 0.273) and intentions (0.157) on taxpayer compliance.
The association of angular cheilitis and HIV patients
Authors: Reiska Kumala Bakti  , Yasmin Kamila Putri  , Indah Alya Zahra  , Dhea Rima Rohita Zulfa
Published: December 2024

Angular cheilitis (AC), an inflammatory condition affecting the corners of the mouth, is commonly observed in HIV-positive populations and has potential as a clinical marker of immune suppression. This scoping review systematically examined studies to assess the association between AC HIV-positive individuals, with a particular focus on CD4+ cell counts and viral loads. A literature search across PubMed, ScienceDirect, and Google Scholar identified relevant studies, emphasizing the clinical characteristics, prevalence, and immunological indicators associated with AC. Findings indicate that AC prevalence increases as CD4+ counts decline, suggesting its utility as an early marker of HIV progression. The data also reveal a high co-occurrence of AC with oral candidiasis, further supporting its association with advanced immunosuppression. Statistical analyses from reviewed studies demonstrated significant correlations between low CD4+ levels and increased risk of AC, reinforcing the potential of AC as a diagnostic cue for immune decline. This review highlights AC as a non-invasive and cost-effective marker that could support early diagnosis and intervention in resource-limited settings, thereby improving HIV management outcomes.
Contributions and significance of women professionals in maritime clusters
Authors: Rose A Arceño
Published: December 2024

Maritime clusters, encompassing industries like shipping, logistics, and marine energy, are pivotal to global economic growth. Despite their contributions, women remain underrepresented in these sectors, holding less than 5% of leadership roles and only 1% of seafaring positions globally. This paper examines the contributions of women in maritime clusters, exploring their roles in governance, sustainability, and innovation. Drawing on global case studies from Norway, Japan, and Singapore, the study highlights strategies for advancing gender equity through the Gender-Responsive Maritime Strategies (GReMS) framework. By integrating inclusivity policies and leveraging digitalization, the maritime sector can unlock significant economic potential, aligning with United Nations Sustainable Development Goal 5 (gender equality) and the global transition to Industry 5.0.
Variability studies and value addition in Gomphrena (Gomphrena globosa L.)
Authors: Supritha T  , Amreen Taj  , Munikrishnappa PM  , Shivapriya M  , Sangeetha CG
Published: December 2024

The present experiment was carried out in COH, Bengaluru. Twelve genotypes of Gomphrena were evaluated for growth, flowering and yield attributes to study their genetic parameters such as variability, heritability, genotypic coefficient of variation (GCV) and phenotypic coefficient of variation (PCV). All traits showed significant difference among the genotypes. The maximum value of GCV and PCV were recorded for individual flower weight, flower petiole length, secondary branches. The highest broad sense heritability was recorded for individual flower weight, secondary branches, primary branches, duration of flowering, plant spread in N-S direction, plant height, and flower petiole length. High heritability and genetic advance as percent mean are due to additive type of gene action. In value addition Two genotypes of Gomphrena namely Gomphrena globosa L.‘white’ and Gomphrena globosa L.‘magenta’ were exposed to air drying and hot air oven drying. The data recorded on fresh weight, dry weight, moisture loss and duration of drying were analyzed by following factorial CRD. With respect to drying methods hot air oven drying retains colour and took minimum time for drying Gomphrena flowers. Hence this method is advantageous over air drying. The interaction effect showed that Gomphrena globosa L.‘magenta’ with oven drying achieved maximum score with respect to colour (20.53), texture (16.78), shape (20.98) and overall acceptability (20.33).
Adverse health effects of heavy metal pollution in the Enugu Area, Southeastern Nigeria
Authors: Fagbemi Oluwaseyi Ajibola  , Ikemefuna Nnamdi Onyeyili  , Maryann Seyram Adabra  , Chekwube Martin Obianyo  , David Joseph Ebubechukwu  , Abdussalam Muhammad Auwal  , Edeh Chinenye Justina
Published: December 2024

Heavy metal pollution in Southeastern Nigeria’s Enugu area presents a severe environmental and public health hazard, with specific locations such as Emene Industrial Area, Ngwo Mechanic Village, and Abakpa experiencing particularly high contamination levels. The primary contaminants—lead, cadmium, arsenic, mercury, and chromium—originate from industrial operations, mining activities, and unregulated waste disposal. In Emene Industrial Area, soil and water samples reveal arsenic and manganese levels significantly above safety thresholds, impacting local residents, especially children and pregnant women. Ngwo Mechanic Village exhibits dangerously high concentrations of lead and chromium due to persistent automobile emissions and industrial effluents, leading to respiratory and neurological health risks for workers and nearby communities. Additionally, agricultural zones like Abakpa are impacted by cadmium from fertilizers, resulting in contamination of crops and local water sources, which poses long-term health risks to consumers. This review examines the sources, pathways, and adverse health effects of heavy metal pollution across these high-risk locations in Enugu, while also recommending mitigation strategies, including stricter environmental regulations, sustainable agricultural practices, and community education to reduce exposure and protect public health.
Analysis of the quality of dental clinic services in increasing patient satisfaction and interest in Re-Treatment at Ali Dental Care Tebing Tinggi
Authors: Muhammad Hisyam Ali Harahap  , Ermi Girsang  , Sri Lestari Ramadhani Nasution
Published: December 2024

Dental and oral health is an essential aspect of overall health. However, quality dental health services in Indonesia, especially in remote areas, still face many challenges. The quality of service in dental clinics significantly affects patient satisfaction and interest in re-treatment. This study uses a quantitative approach with a cross-sectional analytical design to examine the influence of dental clinic service quality on patient satisfaction at Ali Dental Care Tebing Tinggi. Data was collected through a questionnaire distributed to 290 respondents who were incidentally selected from the patient visit population. Data analysis used the Chi-Square test to identify relationships between variables and logistic regression to measure the influence of variables on patient satisfaction. The results showed that variables such as reliability (p-value = 0.015), assurance (p-value = 0.010), display (p-value = 0.020), responsiveness (p-value = 0.012), and empathy (p-value = 0.025) had a significant relationship with patient satisfaction, with a p-value ≤ 0.05. The reliability variable had the highest odds ratio of 3.202, which suggests that an improvement in this aspect can increase patient satisfaction by up to 3.2 times. These findings emphasize the importance of improving the quality of services through coordination between the government, educational institutions, and the community. This research is expected to provide helpful input for clinic management in improving service and patient satisfaction and contributing to developing science in dental health.
Parental health education and its influence on early childhood learning
Authors: Topeola Balkis Awofala  , Lateef Adeola Bilikis
Published: December 2024

Parental health education significantly impacts early childhood learning by shaping children's physical, emotional, and cognitive development. Educated parents can make informed decisions about nutrition, health, and emotional well-being, fostering an environment conducive to early learning. This paper explores the relationship between parental health education and early childhood learning outcomes, identifying key mechanisms, analyzing evidence from diverse socio-economic contexts, and highlighting challenges and limitations. Recommendations for enhancing parental health education programs are proposed, emphasizing inclusive approaches and multi-sectoral collaboration. The study underscores the critical role of empowering parents in fostering sustainable developmental outcomes and achieving global educational goals.
Avances terapéuticos en el abordaje de las fisuras anales: explorando la sinergia entre Farmacología y Nanotecnología
Authors: Pazmiño-Chiluiza Carlos Ostwaldo , González Rodríguez María Luisa
Published: December 2024

Introducción: La fisura anal es una patología proctológica frecuente, cronificante, caracterizada por la presencia de lesiones dolorosas ocasionadas por la hipertonía del musculo liso del esfínter anal interno. A pesar de su impacto, los tratamientos convencionales disponibles pueden ser limitados en términos de reproducibilidad, eficacia y tolerabilidad a largo plazo. Debido a ello, la exploración de nuevas terapias farmacológicas, en sincronía con nanovehículos que permitan su direccionamiento específico al lugar de acción, ofrecen una alternativa potencial para mejorar su tratamiento.
Método: Se plantea como un estudio de tipo retrospectivo y longitudinal.
Resultados: Se aplican diferentes abordajes terapéuticos, desde medidas higiénico-sanitarias, tratamientos farmacológicos no invasivos, hasta la cirugía, la mayoría de ellos dirigidos a disminuir la hipertonía. Los fármacos habituales a nivel hospitalario son lidocaína, diltiazem, nifedipino, nimodipino, nitrato de isosorbide y la toxina botulínica. Aprovechando las ventajas de la nanotecnología farmacéutica en la mejora de la eficacia terapéutica, disminuyendo los efectos adversos generados en la administración sistémica y aumentando la tasa de curación, se han encontrado estudios sobre la aplicación de nanopartículas poliméricas, vesiculares y micro-nano emulsiones para vehiculizar fármacos para el tratamiento sintomático de la fisura anal. Algunas formulaciones cuentan con autorización sanitaria y otras se encuentran en fase de investigación.
Conclusiones: Se ha evidenciado que las nuevas formulaciones, especialmente aquellas basadas en nanotecnología, muestran un potencial significativo para mejorar la cicatrización de las fisuras en comparación con los tratamientos convencionales. No obstante, son necesarios estudios sobre el uso seguro de estos sistemas antes de su implementación clínica generalizada.
Vasculitis cutánea secundaria a tratamiento con levamisol en el síndrome nefrótico en pediatría
Authors: Sánchez Bernaldo Félix , Bravo Mancheño Beatriz , Gómez Mª Amelia , Ortega Morales Ana María , Sevilla Pérez Maria Belén , Gómez Llorente Maria Amelia
Published: December 2024

Introducción: El síndrome nefrótico (SN) es un enfermedad glomerular frecuente en la infancia, siendo la forma más frecuente el SN idiopático (SNI). El tratamiento con levamisol es eficaz en el SNI de recaídas frecuentes y corticoide dependiente. Los estudios describen efectos secundarios leves y en raras ocasiones graves, remitiendo tras la retirada del tratamiento.
Resultados: Se describen dos casos clínicos de SNI de recaídas frecuentes tratados con levamisol que presentaron vasculitis con anticuerpos anti-citoplasma del neutrófilo positivos. En ambos casos se presentaron lesiones cutáneas que tras la retirada del fármaco desaparecieron, evitando el uso de otros tratamientos como corticoides, inmunomoduladores e incluso amputaciones por necrosis cutánea.
Conclusiones: Es importante conocer las posibles complicaciones del tratamiento con levamisol en pacientes pediátricos con SIN para proceder a la retirada del fármaco para su resolución.
La búsqueda de información y su asociación con la producción científica: Obesidad, dieta y salud laboral
Authors: Melián Fleitas Liliana , Franco Pérez Álvaro Moisés , Sanz Valero Javier , Wanden-Berghe Carmina
Published: December 2024

Introducción: Analizar la asociación entre la búsqueda de información sobre obesidad, dieta y seguridad y salud laboral a través de Google, y la producción científica sobre estas materias para conocer si el interés poblacional se relaciona con la actividad investigadora.
Método: Los datos se obtuvieron de la consulta directa, online, a Google Trends (GT) con los términos obesidad, dieta y seguridad y salud laboral y en MEDLINE (vía PubMed), utilizando los Medical Subject Headings “Obesity”, “Diet, Food, and Nutrition” y “Occupational Health”. Las variables estudiadas fueron: volumen de búsqueda relativo (VBR), VBR mensual medio (VBRm), referencias (REF), volumen de referencias relativo (VRR) y Variabilidad.
Resultados: Las tendencias obtenidas (VBRm) en GT fueron en los tres casos decrecientes: obesidad (R2=0,33; p=0,009), dieta (R2=0,68; p<0,001); salud laboral (R2=0,41; p=0,002). Para los VRR obtenidos de MEDLINE fueron crecientes para obesidad y dieta (R2=0,85; p<0,001 y R2=0,85; p<0,001); para salud laboral la tendencia fue no significativa (R2=0,03; p=0,509). La variabilidad obtenida para el VRR frente al VBRm (valor igual a 100) dio: obesidad -18,71, dieta -1,18 y salud laboral 63,65.
Conclusiones: Se constató un interés creciente de la comunidad científica, medido por su producción, sobre obesidad, dieta y salud laboral, mientras que el interés poblacional, sobre estos temas, fue decreciendo a lo largo del periodo estudiado, por lo que la relación producción científica versus búsquedas fue inversa. Por otro lado, se pudo observar un notorio desinterés, de la población e investigadores, en la importancia del lugar de trabajo como vector para la prevención y tratamiento de la obesidad.
Nanobots: The future of drug delivery
Authors: Tadikonda Rama Rao , Aditya Anand
Published: December 2024

Introduction: Since the introduction of nanorobotics, the discipline of medicinal chemistry has seen an exponential development in the uses of nanotechnology. One of the most potential uses of nanotechnology is in the creation of nanobots, which can be applied to a variety of industries such as medicine delivery, medical imaging, and even the benefits of nanobots include their small size, light weight, great flexibility, high sensitivity, and big thrust-to-weight ratio. Nanobots have several uses and are being investigated in many domains. This review’s objective is to provide an overview of the rapidly developing field of medicinal chemistry’s nanorobotics and its potential applications in disease detection, treatment, and prevention.
Method: Several articles and newsletters are considered and used as a reference to collect information regarding nano and microbots and a brief information was written in accordance to use in medicine delivery.
Results: Various review articles were taken into consideration to provide a deep knowledge on the utilization of nano and microbots in drug delivery and treatment therapy of several diseases.
Conclusions: The main parts of the robots and the many kinds of nanobots are covered separately. The future perspective and initiatives that can help us realize our dreams of creating small robots that can move around inside our bodies, administering medication with previously unattainable precision, locating and eliminating infected cells, and most importantly making science fiction, a reality is finally covered.
The influence of principal's leadership, discipline, and teacher motivation on the performance of public elementary school teachers
Authors: Herni Herni , Hidayat Saleh , Fatmasari Rhini
Published: December 2024

How well teachers do their jobs in the classroom has a direct bearing on how well their pupils do in school. In order to determine whether pupils are ready to join the commercial and industrial sector, the efficacy of their teachers is essential. Improving the efficiency of educators has a bearing on the quality of the human capital developed via schools. In order to better understand how teacher motivation affects performance, how discipline affects performance, and how principal leadership affects performance, this research will examine all three of these factors. Furthermore, the research evaluates the impact of principal leadership, teacher motivation, and disciplinary measures on student outcomes. The participants in this quantitative study were 295 educators from Banyuasin I District's State Elementary School. We used a simple random selection strategy to identify 75 instructors for our sample. Data collection was conducted through the administration of questionnaires, which were subsequently subjected to analysis via multiple linear regression methodologies. The influence of principal leadership exhibited a partial positive correlation with teacher performance, while teacher discipline also demonstrated a partial positive correlation with teacher performance; conversely, teacher motivation revealed no discernible partial impact on teacher performance. Furthermore, it was determined that principal leadership, discipline, and motivation collectively exerted a significant influence on student achievement.
Development of digital modules for English subjects for fourth grade elementary school students
Authors: Pratiwi Syahnaz Nabila Anjani , Nurhikmah Nurhikmah , Anwar Citra Rosalyn
Published: December 2024

The study aims to develop a digital module for English subjects in elementary schools. The development follows the flow of the ADDIE model. The study subjects were 2 validators and 9 students during the small group trial and 31 during the large group trial. Data collection used a needs identification questionnaire, a validation questionnaire for material experts and design experts, a small group trial questionnaire, and a test. Data were calculated by calculating scores and percentages for validity and student responses, while the effectiveness test used the Wilcoxn and n-gain tests. The study results found that identifying student needs was in the required qualifications. The results of the validity level of the digital module from the assessment of the material expert validator were 89% and the media/design expert 94% (very valid). The results at the level of practicality obtained from the analysis of the small group response questionnaire were 97 (very practical). Furthermore, the level of effectiveness of the digital module was 0.8 (high), with significant test results showing a significant difference before and after learning. It was concluded that the product can be used in the classroom learning process to teach students English.