bluuebunny/crossref_metadata_2025 huggingface dataset:
Delta Challenges and Nature-based Solutions in Dialogue
Authors: Van Nieuwaal Kim , Frantzeskaki Niki , Cohen-Shacham Emmanuelle
Published: October 2023

The delta areas had been significant for human development.The environmental degradation and the climate change are one of the multiple pressures experienced by urban deltas such as groundwater extractions, land subsidence affecting the provision of ecosystem services that pose extra risk in the livelihoods of the local as well on the global populations living in these areas. Nature-based solutions have proved their potential to counteract some of these pressures. The following talk brings to the fore an interdisciplinary take on the potential, the value as well as the challenges encompassed in designing, planning and governing nature-based solutions for urban deltas. 

This dialogue is the transcription of a series of interviews from the guest editors, Veronica Zagare and Diego Sepulveda with the authors, held during October/November 2022.
A karteziánus emberkép megkérdőjeleződésének esetei a jogban
Authors: Molnár András
Published: October 2023

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A házassági vagyonjogi szerződés érvénytelensége és hatálytalansága az ítélkezési gyakorlat tükrében
Authors: Vörös Judit
Published: October 2023

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Az ötlet védelme a joggyakorlatban és jogalapjának deregulációja
Authors: Schultz Márton
Published: October 2023

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Hozzászólás Pokol Béla jogrendszer-kettőződéssel kapcsolatos elgondolásához
Authors: Szmodis Jenő
Published: October 2023

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A hatalommegosztás és a hatalomfelosztás doktrínája
Authors: Balássy Ádám Miklós
Published: October 2023

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Rechtssystem und Digitalgesellschaft. Transformationsmuster im deutschen Recht
Authors: Gyekiczky Tamás
Published: October 2023

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Az alapjogvédelem eszköze: A magyar, német és a spanyol jogrend összehasonlító elemzése
Authors: Varinic Ouk
Published: October 2023

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„Nem álmod-e az, hogy egyszer láthatatlan légy?” A természettel kapcsolatos felfogás változásai és a szuverenitás kizöldítésének esélyei
Authors: Pongrácz Alex
Published: October 2023

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A bírósági végrehajtási eljárásokban előterjeszthető alkotmányjogi panaszok dilemmáinak vázlatos áttekintése
Authors: Egri-Kovács Krisztián
Published: October 2023

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A társadalmi akadálymentesítés. Az akadálymentesség teljesebbé válásának egyik lehetséges útja a bizalmi vagyonkezelés alkalmazásával
Authors: Farkas Jácint , Nagy Erzsébet Györgyi
Published: October 2023

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Role of Geography Education in Raising Environmental Awareness: A Literature Review
Authors: Rakuasa Heinrich , Latue Philia Christi
Published: October 2023

This research is a literature review that aims to explore the significant role of Geography Education in increasing environmental awareness. This research uses a descriptive Qualitative Method by conducting a literature study related to this research. The results of the literature analysis show that geography education provides an important foundation for students to understand the complex relationship between humans and the natural environment, as well as its impact on the sustainability of the Earth. In addition, it helps students identify global and local environmental problems, provides insight into workable solutions, and encourages an environmentally responsible attitude. This study confirms that geography education has great potential in shaping a generation that is environmentally conscious, ready to participate in nature conservation efforts, and address the increasingly pressing environmental challenges of the future.
Influencia de las plataformas virtuales en el aprendizaje de Introducción al Derecho, en la Facultad de Ciencias jurídicas de la Universidad Mayor de San Simón Bolivia
Authors: Berbety Claros Aldo
Published: October 2023

La investigación tuvo como objetivo determinar la influencia de las plataformas virtuales en el aprendizaje de la materia Introducción al Derecho entre estudiantes de primer año de Derecho de la Facultad de Ciencias Jurídicas de la Universidad Mayor de San Simón en el año 2022. La metodología utilizada fue mixta con un diseño transaccional no experimental. Los resultados del estudio llevaron a la implementación de una propuesta estratégica de enseñanza virtual en la carrera de derecho para brindar una experiencia satisfactoria de aprendizaje a través de plataformas. El estudio concluyó que los estudiantes conocen diferentes plataformas virtuales
Poland’s Sham ‘Migration’ Referendum
Authors: Baranowska Grażyna
Published: October 2023

On June 15, 2023, Jarosław Kaczyński, leader of Poland's PiS party, announced a rare referendum, ostensibly to allow the public to weigh in on crucial elements of Polish immigration policy, alongside the general elections. Yet, in reality, the referendum had little to do with migration and the opposition parties largely ignored the referendum's questions to avoid its deployment as an electoral campaign tool. As such, whatever voters will decide on Election day, it will tell us little about the state of Polish migration politics.
Mikrobiyotaya Etki Eden Etmenler
Authors: EMİR Aleyna , TATAR Tuğba
Published: October 2023

Mikrobiyota birçok mikroorganizmayı içerisinde barındıran, immünolojik, hormonal ve metabolik açıdan önemi son dönemlerde daha fazla anlaşılan bir yapıdır. Mikrobiyota immünolojik sisteminin güçlendirilmesi, bazı vitaminlerin sentezlenmesi, sindirim ve emilim faaliyetlerinin gerçekleştirilmesi, bağırsak bütünlüğünün korunması, inflamasyonun önlenmesi, nörolojik faaliyetler, sağlıklı vücut ağırlığına kavuşulması gibi çok farklı metabolik işlevlerin gerçekleşmesinde önemli roller üstlenmektedir. Mikrobiyotanın oluşumunu ve gelişimini etkileyen birçok faktör bulunmaktadır. Bu derlemede bu faktörlerden bazılarına değinilmiştir. Probiyotikler ve prebiyotikler faydalı mikrobiyal yükü artırarak mikrobiyotanın düzenlenmesinde fayda sağlar. Genel itibariyle bitkisel kaynaklı besinlerde bulunan polifenoller mikrobiyotayı olumlu yönde etkilemektedir. Mikrobiyota ile polifenoller arasında karşılıklı bir ilişki bulunmaktadır. Mikrobiyota polifenollerin biyoyararlılığını ve biyolojik aktivitesini artırabilirken, polifenollerin de mikrobiyotanın faydalı mikrobiyal çeşitliliğini artırabildiği gösterilmiştir. Mikrobiyota ilaçların emilim, metabolizma, toksisite gibi mekanizmalarını etkileyerek kimyasal değişikliklere uğraması ve metabolize edilmesinde önemli roller üstlenmektedir. Bununla birlikte antibiyotikler başta olmak üzere bazı ilaçlar mikrobiyom bileşimi, metabolizması ve konak etkileşimini değiştirebilmektedir. Emülgatörler veya yapay tatlandırıcılar gibi gıda katkı maddeleri mikrobiyota bileşimini etkileyebilmektedir. Emülgatörlerin mikrobiyota disbiyozu ile ilişkili hastalıkları artırdığı gösterilmiştir. Yapay tatlandırıcıların da mikrobiyota üzerine olumsuz etkileri nedeniyle obezite ve glukoz intoleransı eğilimini artırdığı düşünülmektedir. Mikrobiyota leptin ekspresyonu üzerinde etkili olabilmekte ve vücut ağırlığı kazanımında rol oynayabilmektedir. Sonuç olarak mikrobiyotanın bileşimi ve mikrobiyal yükün yoğunluğu insan sağlığı üzerinde birçok olumlu veya olumsuz etki oluşturabilmektedir. Önemi gün geçtikçe daha fazla anlaşılan mikrobiyotaya etki eden etmenlerin daha fazla anlaşılması ve altta yatan mekanizmaların bilinmesi sağlıklı bir mikrobiyota oluşumu için önem arz etmektedir. Sağlıklı bir mikrobiyota oluşturmak obezite, inflamasyon, diyabet gibi birçok hastalığın önlenmesinde ve bireylerin genel sağlığının iyileşmesinde aktif olarak rol oynamaktadır.
La importancia del diagnóstico de las imágenes dentomaxilofaciales
Authors: Hidalgo Rivas Alejandro
Published: October 2023

“Los ojos no ven lo que la mente no sabe”. Esta cita atribuida al escritor inglés D.H. Lawrence, aplica muy bien al diagnóstico por imágenes del territorio dentomaxilofacial, ya que no es posible realizar un diagnóstico por imágenes certero, si no tenemos conocimientos que sustenten dicho diagnóstico. El profesional que realiza la interpretación de las imágenes debe tener conocimientos sólidos de anatomía y patología1. Esta es la única forma de poder discriminar entre estructuras anatómicas normales, variantes anatómicas y patología. Además, este profesional debe conocer en profundidad como se forma la imagen a diagnosticar, para discriminar entre alteraciones que efectivamente están presentes en el paciente, de otras que solo están en la imagen pero no pertenecen al paciente2. También, debe contar con la suficiente información clínica, que le permita analizar las posibles manifestaciones que estos antecedentes clínicos muestren en las imágenes3. Sumado a lo anterior, debe realizar la evaluación de las imágenes en condiciones de visualización optimas4, y de forma sistemática5, para extraer el máximo de información de las imágenes.
A Study of the Link Between Individual’s Biographical Variables and Propensity for Entrepreneurial Leadership
Authors: Charity Khuboni Thembisa , Kayambazinthu Msosa Steven , Alson Ntshangase Bhekabantu
Published: October 2023

After graduation, graduates of higher education institutions are faced with a difficult choice: to work for an organisation or to open their own business. A significant role in the decision-making process is played by the personal qualities of the individual, as well as the presence of initiatives in the higher educational institution aimed at fostering among students the desire for their own entrepreneurial activity as an alternative to traditional employment. The purpose of this study is to test the hypothesis that an individual’s propensity for entrepreneurial leadership by starting his own business depends on his biographical data (age, gender, academic level, academic field, race, and nationality). The methodological tools of the research are methods of descriptive, quantitative, and cross-sectional research. The object of the study is a sample of 332 university students in South Africa. The research was carried out in the following logical sequence: at the first stage, 332 respondents − students of a higher educational institution in South Africa – were selected using a random sample. With the help of the answers to the questions, the respondents expressed their attitude towards independent entrepreneurial activity. Data processing and analysis were carried out using SPSS software using descriptive and logical statistics tools. The results of empirical calculations prove the lack of influence of gender, race and entrepreneurial intentions on respondents’ propensity to carry out their own entrepreneurial activities. At the same time, there is a statistically significant difference in the attitude to entrepreneurship depending on the nationality of the respondents, their age and specialty of study: respondents under the age of 24 are more inclined to start their own business, compared to respondents older than 35; South Africans are more likely to start their own business than Zimbabweans. The study empirically confirms and theoretically proves the presence of numerous problems that reduce students’ inclination to entrepreneurial activity as an alternative option for their career development. Based on the results of the research, it was concluded that starting their own business by graduates requires their social support: the government should change tactics and policies regarding the development of entrepreneurship, and higher educational institutions should pay more attention to measures aimed at encouraging students to open their own business. The results of the conducted research can be useful for activating the development of entrepreneurship in developing countries, from the point of view of understanding the motives and attitude of graduates of higher educational institutions to the development of their careers through the implementation of independent entrepreneurial activities.
Leadership of Small and Medium Scale Enterprises (SMEs), Inflation and Economics Development in Nigeria (1981-2021)
Authors: Olajide Olaniyan Samson , Bimpe Adepeju Morakinyo
Published: October 2023

One of the important components of economic development which contributes to the growth of the population employment level is the increase in the country’s export potential, development of domestic market of goods and services and small and medium – sized entrepreneurship. It plays special role in the filling of state budget in countries with low and medium level of economic development. The purpose of this paper is to model the relationship between the level of economic development of the country as an indicator of the functioning of small and medium- sized enterprises, assessment of the impact of inflation on the level of economic development. The information base of the research is the data of the World Bank, National Bureau of Statistics of Nigeria, and annual statistical bulletin of the Central Bank of Nigeria. The object of the study is indicators of the functioning of small and medium-sized enterprises and economic development in Nigeria, the period of study is 1981-2021. As dependent variables characterized by the development of a small and medium- sized enterprise, the volume of income per unit of capital was chosen and the GDP was chosen as an indicator of the country’s economic development. Factor variables are characterized by the relationship between the development of small and medium-sized enterprises and the economic development of Nigeria. These include gross capital formation, interest rate, exchange rate and inflation rate. The methodological tools for researching the relationship between the analyzed indicators are the method of estimating the autoregressive distributed lag, the extended Dickey Fuller test and Granger test. According to the results of econometric modeling, the negative impacts of the growth of the exchange rate and the level of inflation on the development of the Nigerian economy has been proven. Thus, a 1% increase in exchange rate would lead to a 0.01% decrease in GDP, while a 0.01% decrease in inflation would be accompanied by an increase in GDP of about 1%. At the same time, gross capital formation exerts a positive and statistically significant influence on the volume of GDP (an increase of 1% will lead to an increase of GDP by approximately 7%). Based on the results of the research, it was concluded that stimulating the growth of investment in small and medium- sized enterprises by simplifying access to credit resources, infrastructure development and capacity building is a prerequisite for long- term socio- economic development of Nigerians.
The impact of digital education initiatives
Authors: Melnyk Mykola , Blyznyukov Andriy , Cieślik Jakub
Published: October 2023

The article summarizes the arguments and counterarguments of the scientific debate regarding the impact of digital education initiatives on human capital development in Ukraine. The study’s primary goal is to determine the effect of digital educational initiatives on human capital development. The systematization of literary sources and approaches to solving the problem indicates that the debate about the advantages and disadvantages of digital education in Ukraine continues until now. The urgency of solving this scientific problem lies in the fact that digital education is essential for the state’s educational policy and the country’s general development of human capital. The study of the topic in the article is carried out in the following logical sequence: a review of the literature to determine the advantages and disadvantages of digital education in Ukraine and an assessment of the impact of digital education on the development of skills and abilities of education seekers. An in-depth retrospective analysis of scientific works was carried out to obtain a comprehensive understanding of the subject of research. To solve the set goal, the methods of statistical analysis and questionnaires were used in the work. The object of the study is digital education initiatives in Ukraine. The effectiveness of initiatives in improving students’ knowledge, abilities, and employment prospects is analyzed. The study empirically confirms and theoretically proves that digital education initiatives positively affect the development of human capital in Ukraine. Educators who have mastered the skills of working on digital platforms demonstrate improved critical thinking and teamwork skills. The results show that these initiatives improve students’ skills, knowledge and employability. The development of digital education also requires establishing fair access to digital educational materials, especially in rural areas, and improving pedagogical workers’ qualifications in using digital products. The findings contribute to the broader academic discourse on the relationship between digital education and human capital growth, providing ideas for future research.
Third-country economic consequences of Western sanctions on Russia: a thematic analysis of expert opinions in Azerbaijan
Authors: Niftiyev Ibrahim
Published: October 2023

With the beginning of a new phase of military conflict between Russia and Ukraine in 2022, third countries, especially countries of the former Soviet Union (post-Soviet space), are expected to suffer from Western sanctions and Russian countermeasures due to disruption or disruptions in supply chains. The systematization of literary sources on this topic proves that several studies are currently devoted to analysing the impact of international sanctions against Russia on the situation in the Baltic region. At the same time, the issue of the effects of Russian sanctions on the functioning of Azerbaijan in this context has yet to be analyzed. However, close relations between Russia and Azerbaijan and the growing importance of Azerbaijan for European energy security are essential conditions for this case study. This article aims to investigate the economic impact of sanctions on Azerbaijan through a thematic analysis of expert opinions on social media platforms (e.g. Facebook, LinkedIn) and websites dedicated to media coverage of this issue. This study analyzed 134 qualitative sources collected between February and July 2022, of which 84% of the data was in text format, while 16% was in video format. A technical assessment of expert opinion found that international trade, services (such as banking and transport), agriculture, monetary issues (inflation due to rising prices of imported products and the exchange rate) and migrants were the most discussed issues and causes of concern among experts. Significant disruptions in the Russian economy raise severe concerns about Azerbaijan’s fruit and vegetable exports, wheat imports, banking operations, inflation, reduced remittances (from Russia) and labor migration (from Russia to Azerbaijan). This study examines these patterns in light of prior expectations, suggests further research, and theorizes possible reasons for the observed patterns.
Features of the Implementation of a Comprehensive Support Program for Young Children with ASD Based on the Low-intensity Denver ESDM Model
Authors:   Institute of Special Education and Psychology MSPU Moscow, Russia, Karanevskaya Olga V. , Shargorodskaya Liudmila Vyacheslavovna ,   Regional Non-profit Organization “Center for Curative Pedagogics”
Published: October 2023

Withing the framework of project "Scientific and Methodological Center" of Regional Non-profit Organization "Center for Curative Pedagogics", the interim results of a scientific study were analyzed, the purpose of which is to develop a comprehensive model of care for children with ASD and ASD risk at the age of 2 to 4 years. The results of assessment of the experimental group are presented, using the ADOS-2 diagnostic examination plan, the Communication Matrix, as well as the assessment of the functioning of each child in accordance with the List of Target Skills developed in the Denver Early Intervention Model. The main directions for the development of a comprehensive model of care that meet the identified features of the development of children with ASD are described
Influence of Environmental Factors in the Activities of the Playgroup on Communicational Performance of Children with Autism Spectrum Disorders
Authors:   Regional non-profit social organization “Center for Curative Pedagogics”, Moscow, Russia, D. D. , Kazdym Y. , Karanevskaya O. , Kharlamova E.
Published: October 2023

within the framework of the project "Scientific and Methodological Center", implemented by Regional Non-profit Organization "Center for Curative Pedagogics", a model playgroup for children with autism spectrum disorders (ASD) was created. The playgroup pursues goals from different areas of children's development. A complex of individual and group activities is compiled depending on the main tasks and characteristics of a particular child. The purpose of the study was to identify environmental factors in playgroup activities that contribute to the successful use of communication skills by children with ASD and positively influence their development. In developing situations, certain criteria for the organization and impact of the environment have been identified. A limited number of case studies show that children with ASD communicate better in spaces with low noise levels and fewer people. For children with ASD, it is important to be able to manage the interaction and influence the activity of the communicative partner. Further study of environmental factors requires the analysis of more cases
Development of Symbolic Mediation of Subject-Subject Interaction in the Context of the Problem of Socialization of Schoolchildren with Mental Retardation
Authors:   Belarusian State University, Minsk, Republic of Belarus, Polyakov Alexey М.
Published: October 2023

A variety of problems of children and adolescents with mental retardation (MR) associated with the formation of the subject-subject relations in the context of difficulties in developing symbolic mediation of interaction and especially manifested at school age are identified and described. The notions about the structure of the symbolic function of consciousness and the typology of symbolic forms are given, which allow designing the practice of helping children and adolescents with MR to develop symbolic mediation of subject-subject interaction and increase the possibility of their socialization
A Comprehensive System of Vocational Counseling for People with Disabilities through the Activities of Resource Training and Methodological Centers
Authors:   Pushchinsky State Natural Science Institute   Pushchino, Moscow Region, Russian Federation, Bikbulatova A.A.
Published: October 2023

The analysis of the leading trends in the development of modern systems of vocational guidance for people with disabilities in Russia and abroad has been carried out. In order to develop inclusive education, 46 resource educational and methodological centers of secondary vocational education have been created in 42 regions of the Russian Federation. The development of inclusion in the system of higher education is provided by a network of 21 resource educational and methodological centers to support the education of people with disabilities (REMC). The main directions of vocational counseling work of the REMC are described, which made it possible to achieve in 2022 a 12% growth rate in the number of people with disabilities entering universities compared to the previous year
Peculiarities of Choosing the Diagnostic Tools in Work with Children with Severe Multiple Developmental Disorders and Severe Intellectual Disabilities
Authors:   Moscow State University of Psychology and Education Moscow, Russia, Vetrova Maria A.
Published: October 2023

The possibilities of using various diagnostic tools designed to assess the development of children with disabilities in the diagnostics of children with severe multiple developmental disorders are considered. The advantages and disadvantages of these tools are assessed, the need for development and fixation of practical experience in their use is pointed out
The Different as Significant Other: The Ascent to Humanity in the Age of Loss of Face
Authors:   Lomonosov Moscow State University, Asmolov Alexander G.
Published: October 2023

Preface to the Proceedings of the Conference "The Value of Everyone. The Life of a Person with Mental Disorder: Support, Life Arrangements, Social Integration"
Peculiarities of Ophthalmological Examination and Selection of Optical Correction in Children with Complex Concomitant Pathology
Authors:   Charitable Foundation “Doroga Zhizni”, Vasilyeva Raisa S. ,   Federal Budgetary State Institution “Scientific and Medical Research Center for Obstetrics, Gynecology and Perinatology n.a. Academic Kulakov V.I.”
Published: October 2023

The main objectives and special techniques of ophthalmological examination and optical correction in children with complex concomitant pathology, including disorders of mental and speech development, are described. The importance of identifying and correcting pathologies of the visual analyzer at an early age of a child is emphasized. Particular attention is paid to the children living in orphanages for children with disabilities
Four-Dimensional Symptom Questionnaire (4DSQ) in the Primary Healthcare Practice of Therapists
Authors: Klabbers Gert A.
Published: October 2023

The importance of clinimetrics is ever-increasing. The government, health insurance companies and clients demand more and more visibility of the quality of healthcare. In the framework of the multidisciplinary consultation of (para)medical and psychological disciplines it is necessary to be able to communicate about this in a clear-cut manner. As a haptotherapist and a general physiotherapist I work with Marga Hoeksema (psychomotor therapist) and Christa van Meerten (psychosomatic physiotherapist) in our therapy center in Apeldoorn, the Netherlands.

During meetings it struck me that due to our different areas of expertise and different work methods we communicate with each other in a specific jargon. We also use a variety of measuring instruments, which is not always practical when exchanging client information. Sometimes it is practical, because clearly for instance the range of motion (ROM) of the knee joint is better measured with a goniometer than with a questionnaire, a person's weight is measured with weighing scales and their height is measured with a height measure – all this is clear. However, when it comes to measuring psychological symptomatology there are several questionnaires available, and that diversity can be unpractical for communication.

As a supporting instrument for communication within the practice the Four-Dimensional Symptom Questionnaire (4DSQ) stands out for me, partly because the 4DSQ is used a lot by primary physicians and also because of the convenience with which in merely ten minutes one can gain an impression of Distress, Depression, Anxiety and Somatization. For a scientific comparison of the 4DSQ with other questionnaires I refer to the article "What does the Four-Dimensional Symptom Questionnaire Measure compared to other Measuring Instruments" (Terluin, 1998, in Dutch)

In this article "Four-Dimensional Symptom Questionnaire (4DSQ) in the Primary Healthcare Practice of Therapists" is more of a vision document that reports on the pilot "4DSQ Research Haptotherapy" ii and pleads for experimenting with the Four Dimensional Symptom Questionnaire as an instrument to measure the effect of therapeutic interventions.
Sociodemographic factors associated with depression in people living with epilepsy in Kano, Nigeria
Authors: Owolabi SD
Published: October 2023

Background: A high level of co-morbidity exist between epilepsy and depressive disorder, and in fact it has been found to be the commonest psychiatric disorder in people with epilepsy, with consequence of huge psychosocial burden and poor quality of life. Sociodemographic factors that have been implicated in the association between depression and epilepsy include age, female gender, unemployment, low level of education amongst others.

Objective: To determine the sociodemographic factors associated with depression in people living with epilepsy (PWE) in Kano, Nigeria.

Materials and Methods: In this cross- sectional study, two hundred and fifty- five consecutive patients with epilepsy attending the outpatient epilepsy clinics of Kumbotso Health Centre and Neurology/Psychiatry clinics of Aminu Kano Teaching Hospital, Kano were recruited.

Inclusion criteria were age above 18years and being seizure free for two weeks. Patients with severe neurological and cognitive deficits were excluded. Sociodemographic characteristics were obtained using a structured proforma. Diagnosis of depression was made using the M.I.N.I. International Neuropsychiatric Interview.

Results: The age range of participants was 18-76 years with a mean of 32 years (SD=1.31). Majority of participants (57.6%) were males. Prevalence of depression was 20.4%. There was no difference in the mean age of depressed and non-depressed participants. Females had a higher frequency of depression (32%) and association between gender and depression was statistically significant (p ˂ 0.001). Being divorced/widowed and having tertiary level of education were more associated with depression.

Conclusion: Depression is common in PWE with being female a significantly associated factor.
Programas de Exercício e Prevenção de Quedas: Um estudo piloto para identificar necessidades dos idosos a residir na comunidade
Authors: Correia Martins Anabela
Published: October 2023

As quedas são a maior causa de acidentes e de compromisso da condição de saúde das pessoas idosas, representando a principal razão na admissão aos serviços de urgência, morte prematura, problemas de saúde sérios e incapacidade, imobilidade, disfunção psicológica e institucionalização, estimando-se que 30% das pessoas com 65 ou mais anos caiam, pelo menos, uma vez por ano (Gillespie et al., 2012; NICE, 2013). Por este motivo, têm sido desenvolvidos vários programas, que vão desde o exercício à educação, para prevenir as quedas e suas consequências. Objetivos: Caracterizar a capacidade funcional (velocidade da marcha, equilíbrio, levantar e sentar numa cadeira), a história de quedas, o medo de cair, a autoeficácia para o exercício e a existência de polimedicação de pessoas com idade igual ou superior a 60 anos, a residir na comunidade; e perceber a relação entre esses fatores para, posteriormente, delinear estratégias de abordagem para a prevenção de quedas. Metodologia: Estudo descritivo e exploratório, com 64 participantes (71,9% mulheres) com idade média de 70 anos (DP=7,91), a residir na comunidade; 1/4 com história de queda, 37,5% medo de cair, cerca de metade, polimedicados e 23,4% com dificuldades a levantar e a sentar numa cadeira. Velocidade da marcha ≤1,2 m/s em cerca de 1/3 dos participantes, o ponto de corte para risco na travessia de ruas (M=1,41 m/s, DP=0,37); equilíbrio M=53,9%, DP=25,31 e autoeficácia para o exercício M=14,18, DP=4,38. Resultados: Tanto a velocidade da marcha como o equilíbrio são mais elevados nos participantes que não acusam medo de cair, que não estão polimedicados e que não precisam de ajuda para se levantar de uma cadeira. A autoeficácia para o exercício diminui com a idade e correlaciona-se positivamente com melhores perfis funcionais (equilíbrio e velocidade da marcha). Conclusões: Os resultados indiciam que a população idosa apresenta características funcionais, psicológicas (medo de cair e autoeficácia para o exercício) ou clínicas (história de quedas e medicação) distintas, sendo fundamental conhecê-las para tomar decisões em relação ao programa de prevenção de quedas, nomeadamente a prescrição de exercício (níveis e formatos de prescrição, tipo de atividade, contexto em que os diferentes agentes poderão atuar, de acordo com as suas competências e responsabilidades, e aspetos motivacionais para melhorar a adesão) e educação, centradas em abordagens individualizadas, que devem ser monitorizadas e revistas regularmente, capacitando a pessoa a lidar com adversidades e minimizando os riscos de queda e incapacidade.
THE IMPORTANCE OF DIGITIZATION IN THE POST-WAR RECOVERY OF THE ECONOMY
Authors:   Simon Kuznets Kharkiv national university of economics, Kharkiv, Ukraine, Matviienko-Biliaieva Galyna
Published: October 2023

Ukraine has made significant progress in developing digital technologies in recent years, with an average of 289% improvement in Internet access in all regions over the past decade. However, Russiaâ€™s large-scale aggression against Ukraine is causing severe problems in this area. There is also a digital divide in providing regions of Ukraine with Internet access. As a result of the conflict in Ukraine, attention has been drawn to the need for digital identification solutions: displaced persons often lose access to their physical documents. At the same time, there is an urgent need to confirm their identification data in host countries. If the war continues, the focus must be on keeping businesses and citizens connected to the Internet and modernizing the communications and infrastructure of public services. Digital technologies should become a critical factor in Ukraineâ€™s post-war recovery. The study aims to analyze the characteristics of digitalization in terms of infrastructure, public services, and the digital economy. Thus, the study confirms that the reduction in the level of digital inequality has a high correlation with the growth of digitalization. In addition, the development of the level of digitalization is directly proportional to the efficiency of the IT industry. Thus, the IT sector in the first quarter of 2022 provided export revenue of 2 billion US dollars, which is 28% more compared to the previous year. The war caused significant disruptions to the sector, but increased international attention could open substantial opportunities for future development.
THE ASSOCIATION BETWEEN NATURAL DISASTERS - TRADE: LITERATURE REVIEW
Authors:   İstanbul Mineral and Metals Exporters’ Association (İMMİB), İstanbul, Turkey, Seven Furkan , Uslu Meral ,   İstanbul Mineral and Metals Exporters’ Association (İMMİB), İstanbul, Turkey, Guney Sahan Bulut ,   İstanbul Mineral and Metals Exporters’ Association (İMMİB), İstanbul, Turkey
Published: October 2023

In this study, a literature review has been conducted to understand the association between natural disasters and trade. The hypothesis of the study is that although natural disasters have a significant impact on trade, they have not been extensively examined in academic literature. The purpose of the study is to determine the accuracy of the claim presented in the hypothesis. Various publications published in the last 12 years, containing pre-defined related keywords, have been analyzed. Studies have been grouped according to the years of publication, sources of disaster data used, level of analysis, methods/ models employed, and the results they reached. As a result of this review, the aim is to find the gap in the literature regarding the association between natural disasters and trade, and consequently recommend a road map for future studies. The findings of this review indicate that most studies concluded that natural disasters negatively affect international trade. However, divergent results emerged in studies using different econometric models or focusing on specific contexts. The review highlights the need for diversifying studies in the literature at a micro-level and with different models. To achieve more specific and clear results, future research should examine the factors determining the impact of natural disasters on international trade data separately and increase the diversity in the econometric approaches used. Increasing research on regional and national levels is important for policymakers in high-risk areas. Raising the number of studies is extremely crucial for reducing the impact of natural disasters and developing effective strategies.
DIAGNOSTICS OF CRISIS SITUATIONS IN THE MANAGEMENT OF FINANCIAL SECURITY: AN EXAMPLE OF FOOD INDUSTRY ENTERPRISES
Authors:   West Ukrainian National University, Ternopil, Ukraine, Zhukevych Svitlana , Zhuk Natalia ,   National Academy of the Security Service of Ukraine, Kyiv, Ukraine
Published: October 2023

Food industry enterprises play an important role in the economy. They provide the population with food, create jobs, and make a significant contribution to the production of the gross domestic product. However, competition and an unstable market situation lead to crisis situations. Therefore, for the financial security of the enterprise, it is necessary to determine and analyze the probability of bankruptcy in advance and diagnose the reasons for its occurrence. The methods of discriminant analysis and economic and statistical forecasting create opportunities for determining the probability of the occurrence of crisis phenomena. The purpose of the study is to compare approaches and methods of forecasting the probability of crisis phenomena and to determine the factors that cause them. The article, based on the example of a leading Ukrainian company in the food industry, provides the results of the application of various models for determining the probability of bankruptcy by Beaver, E. Altman, Tafler, K. Springate, and domestic models. Thus, the study confirms the possibility and expediency of using the above-mentioned models to predict the probability of bankruptcy of enterprises. The key factors that affect the companyâ€™s activity and can be the causes of crisis situations are identified. The implementation of forecasting models in management activities makes it possible to predict the onset of crisis phenomena and generate measures to prevent bankruptcy and ensure financial security in competitive conditions of instability and uncertainty of the market environment.
PERANCANGAN PRODUK PLAKAT TIMAH MENGGUNAKAN METODE TAGUCHI DI CV. MITRA GLOBAL PROMOSI
Authors: Theodore Reyhan Aldorino
Published: October 2023

Masalah yang ditemukan dalam penelitian pada proses produksi timah di CV. Mitra Global Promosi adalah kesulitan untuk mengidentifikasi faktor sehingga tidak diketahui komposisi terbaik dari faktor yang mempengaruhi kualitas produk dan tidak diketahui nilai kerugian untuk memproduksi plakat berbahan timah jika tidak sesuai dengan kualitas yang diharapkan. Dengan menggunakan metode taguchi tujuan penelitian dalam penulisan tugas akhir dengan menekan jumlah percobaan semaksimal mungkin, sehingga menghemat biaya dan sumber daya yang digunakan untuk mendapatkan hasil yang optimal. Faktor yang mempengaruhi kualitas produk berupa suhu, waktu, dan antimon. Dengan melakukan percobaan menggunakan metode taguchi didapatkan hasil faktor pada kondisi optimal berupa suhu 235,7oC, waktu 10 menit, dan antimon 20 gram. Hasil perhitungan nilai kerugian pada percobaan aktual didapatkan hasil Rp.112,822 dan hasil pada percobaan kondisi optimal didapatkan hasil Rp.87,328.
Hamdard Institute of Pharmaceutical Sciences, Hamdard University, Pakistan
Authors:   School of Pharmacy, Institute of Technology Bandung, West Java, Indonesia, Utami Ratna Annisa
Published: October 2023

Tablet production is a very intricate process influenced by numerous process variables or parameters. This study aimed to identify the critical processing variables that affect Critical Quality Attributes (CQAs) of vitamin C film-coated caplets utilizing a statistical experimental design. A two-level complete factorial design with two central points was used to examine the process parameters that posed the greatest risk to CQAs. The process variables investigated included mesh size and duration for the lubrication process, as well as speed and main thickness for compression. Statistical results showed that mesh number, lubrication time, and their interaction significantly affect flow rate, Hausner ratio, and compressibility index. Higher mesh number and longer duration improved flow properties; lower main thickness significantly increased core caplet hardness; and lower dissolution rates were observed at higher compression speeds. Based on this study, it can be concluded that mesh number and lubrication time only significantly affected the bulk quality attributes but did not have a significant impact on the quality attributes of vitamin C caplets. On the other hand, the parameters of the compression process, such as speed and main thickness, greatly impacted the quality attributes of vitamin C caplets. In this study, the use of mesh number 20 with 7 minutes of lubrication, and a speed of 17 rpm with a main thickness scale of 2.00 were determined as the optimal process parameters. The optimal process parameters for the lubrication and compression processes were obtained from statistical analysis of the response data.
New approaches of (q,k)-Fibonacci–Pell sequences via linear difference equations. Applications
Authors:   Mathematics Department, Universidade Federal da Grande Dourados, Craveiro Irene Magalhães , Pereira Spreafico Elen Viviani ,   Institute of Mathematics, Universidade Federal de Mato Grosso do Sul, Rachidi Mustapha ,   Institute of Mathematics, Universidade Federal de Mato Grosso do Sul
Published: October 2023

In this paper we establish some explicit formulas of (q,k)-Fibonacci–Pell sequences via linear difference equations of order 2 with variable coefficients, and explore some of their new properties. More precisely, our results are based on two approaches, namely, the determinantal and the nested sums approaches, and their closed relations. As applications, we investigate the q-analogue Cassini identities and examine a pair of Rogers–Ramanujan type identities.
Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development
Authors: Yuan Tian , Wang Yifan , Jin Yuchen , Xu Shuai , Zhang Heng , Chen Qian , Li Na , Ma Xinyue , Song Huifang , Peng Chao , Yang Hui , Geng Ze , Dong Jie , Duan Guifang , Sun Qi , Yang Yang , Yang Fan , Huang Zhuo
Published: October 2023

Quinidine has been used as an anticonvulsant to treat patients with KCNT1-related epilepsy by targeting gain-of-function KCNT1 pathogenic mutant variants. However, the detailed mechanism underlying quinidine’s blockade against KCNT1 (Slack) remains elusive. Here, we report a functional and physical coupling of the voltage-gated sodium channel Na
V
1.6 and Slack. Na
V
1.6 binds to and highly sensitizes Slack to quinidine blockade. Homozygous knockout of Na
V
1.6 reduces the sensitivity of native sodium-activated potassium currents to quinidine blockade. Na
V
1.6-mediated sensitization requires the involvement of Na
V
1.6’s N- and C-termini binding to Slack’s C-terminus, and is enhanced by transient sodium influx through Na
V
1.6. Moreover, disrupting the Slack-Na
V
1.6 interaction by viral expression of Slack’s C-terminus can protect against Slack
G269S
-induced seizures in mice. These insights about a Slack-Na
V
1.6 complex challenge the traditional view of “Slack as an isolated target” for anti-epileptic drug discovery efforts, and can guide the development of innovative therapeutic strategies for KCNT1-related epilepsy.
Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis
Authors: Patel K , Barter MJ , Soul J , Clark P , Proctor CJ , Clark IM , Young DA , Shanley DP
Published: October 2023

Changes in chondrocyte gene expression can contribute to the development of osteoarthritis (OA), and so better understanding of the regulative processes during chondrogenesis can highlight potential drug targets for OA. microRNAs (miRNAs) have been a focus of chondrogenesis/ OA research and we have used a combined experimental, bioinformatic, and systems biology approach to explore multiple miRNA-mRNA interactions that regulate chondrogenesis. We identified paralogues miR-199a-5p and miR-199b-5p as pro-chondrogenic regulators of chondrogenesis through bioinformatic analysis. Experimental work demonstrated alteration of miR-199a-5p or miR-199b-5p expression led to significant inverse modulations of chondrogenic biomarkers:
ACAN
,
COL2A1
,
SOX9
and glycosaminoglycan levels. Potential miR-199a/b-5p targets were then identified using RNAseq combined with bioinformatic analysis to identify
FZD6, ITGA3
and
CAV1
as highly likely candidates. Through knockdown experiments we indicated a strong antagonistic relationship between miR-199a/b-5p and
FZD6
,
ITGA3
and
CAV1
. Luciferase assays using
FZD6
and
ITGA3
3’UTRs luciferase assays indicated both mRNAs to be targets of
miR-199a-5p.
The experimental work was used to generate and parameterize a multi-miRNA 14-day chondrogenesis kinetic model to be used as a repository for the experimental work and as a resource for further investigation of this system. This is the first multi-miRNA model of a chondrogenesis-based system, and it highlights complex relationships between regulatory miRNAs, and predicted indirect miRNA-miRNA interactions, via modulation of miR-140-5p by knockdown of miR-199a/b-5p.
Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase
Authors: Colin Léonard , Reyes Céline , Berthezene Julien , Maestroni Laetitia , Modolo Laurent , Toselli Esther , Chanard Nicolas , Schaak Stephane , Cuvier Olivier , Gachet Yannick , Coulon Stéphane , Bernard Pascal , Tournier Sylvie
Published: October 2023

The localization of condensin along chromosomes is crucial for their accurate segregation in anaphase. Condensin is enriched at telomeres but how and for what purpose had remained elusive. Here we show that fission yeast condensin accumulates at telomere repeats through the balancing acts of Taz1, a core component of the shelterin complex that ensures telomeric functions, and Mit1, a nucleosome-remodeler associated with shelterin. We further show that condensin takes part in sister-telomere separation in anaphase, and that this event can be uncoupled from the prior separation of chromosome arms, implying a telomere-specific separation mechanism. Consistent with a cis-acting process, increasing or decreasing condensin occupancy specifically at telomeres modifies accordingly the efficiency of their separation in anaphase. Genetic evidence suggests that condensin promotes sister-telomere separation by counteracting cohesin. Thus, our results reveal a shelterin-based mechanism that enriches condensin at telomeres to drive in cis their separation during mitosis.
Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies
Authors: Lu Xiuyuan , Hayashi Hiroki , Ishikawa Eri , Takeuchi Yukiko , Dychiao Julian Vincent Tabora , Nakagami Hironori , Yamasaki Sho
Published: October 2023

SARS-CoV-2 vaccines have been used worldwide to combat COVID-19 pandemic. To elucidate the factors that determine the longevity of spike (S)-specific antibodies, we traced the characteristics of S-specific T cell clonotypes together with their epitopes and anti-S antibody titers before and after BNT162b2 vaccination over time. T cell receptor (TCR) αβ sequences and mRNA expression of the S-responded T cells were investigated using single-cell TCR– and RNA-sequencing. Highly expanded 199 TCR clonotypes upon stimulation with S peptide pools were reconstituted into a reporter T cell line for the determination of epitopes and restricting HLAs. Among them, we could determine 78 S epitopes, most of which were conserved in variants of concern (VOCs). In donors exhibiting sustained anti-S antibody titers (designated as “sustainers”), S-reactive T cell clonotypes detected immediately after 2nd vaccination polarized to follicular helper T (Tfh) cells, which was less obvious in “decliners”. Even before vaccination, S-reactive CD4
+
T cell clonotypes did exist, most of which cross-reacted with environmental or symbiotic bacteria. However, these clonotypes contracted after vaccination. Conversely, S-reactive clonotypes dominated after vaccination were undetectable in pre-vaccinated T cell pool, suggesting that highly-responding S-reactive T cells were established by vaccination from rare clonotypes. These results suggest that
de novo
acquisition of memory Tfh cells upon vaccination contributes to the longevity of anti-S antibody titers.