bluuebunny/crossref_metadata_2025 huggingface dataset:
Emergency Flight Control Based on the Fan Wing
Authors: Meng Lin , Wang Shuo , Chen Ye , Gao Yang
Published: November 2021

FanWing has been taken to the visual field because of its performance combination of fixed-wing aircraft and helicopter. Its flight mode is currently limited mainly by a remote control, while the research of automated flight control is on the rise. The fan wing could offer lift, thrust, and the additional pitch moment for longitudinal control. At the same time, the roll moment and the yaw moment can be generated by the differential rotation of the cross-flow fan to realize the lateral control. It provides the possibility for its emergency flight control when the aerodynamic control becomes inefficient at a low speed. The difficulties in designing the emergency control system in both the longitudinal and lateral controls are analyzed. And it emphasizes the importance of selecting its center of gravity and the emergency control method of longitudinal control in engineering. The simulation results show that as an emergency flight control system, fan wing control is feasible. The study of the fan wing control will provide a reference solution for its further engineering applications.
A Study Using Power Cycling on the Affective Responses of a Low-Volume High-Intensity Interval Training to Male Subjects with Type 2 Diabetes in Different Physical Activity Status
Authors: Li Jun , Jiang Ruichen , Cheng Wei , Ma Haifeng
Published: November 2021

High-intensity interval training (HIIT) has been shown in studies to enhance glucose management and cardiovascular well-being in patients with type 2 diabetes. In this study, we used power cycling to assess the physical activity levels of men with type 2 diabetes during a single low-volume HIIT session. First, fifty-six men with type 2 diabetes volunteered to take part in the study, and they were split into two groups based on the International Physical Activity Scale Short Form (IPA). To the first 1–4 labor bouts, both the sufficiently physically active and insufficiently physically active groups exhibited equal positive emotional reactions (

p
>
0.05

). However, over time (about 5–10 times), both of them showed reduced emotional reactions, with a significant difference (

p
<
0.01

). The insufficiently physically active group had lower mean emotional response, lowest effective response, and maximum effective response values than the sufficiently physically active group (

p
<
0.001

), while the difference in RPE between the two groups was not statistically significant (

p
>
0.05

). From the standpoint of emotional response, the proposed model shows that HIIT or reduced volume HIIT exercise prescriptions should be utilized with caution in physical activity programs for novices and less active and chronically sick persons. The frequency, intensity, and effects of low-volume HIIT on individuals’ emotional reactions and health conditions in the T2DM group are also investigated. Furthermore, this low-volume HIIT program can be successfully applied in the real-world setting of people who are not physically active enough or who are chronically unwell.
Estimates of Prevalence of Pulmonary Hypertension according to Different International Definitions
Authors: Tyagi Richa , Kant Surya , Pradhan Akshyaya , Wakhlu Anupam , Bajaj Darshan Kumar , Bajpai Jyoti
Published: November 2021

Background. Pulmonary hypertension is a dreaded disease associated with considerable morbidity and mortality. The pulmonary hypertension developing due to chronic respiratory disease is a unique subset with symptoms often getting masqueraded by the underlying respiratory condition. The importance of early detection of this complication has been realized worldwide, and recently, the definition of pulmonary hypertension was revised to set the cutoff of mean pulmonary artery pressure (mPAP) at 20 mmHg instead of 25 mmHg at rest. In our study, we have tried to estimate the difference this new definition brings to the prevalence of pulmonary hypertension among interstitial lung disease patients at our centre. Methods. This was a cross-sectional study in which all the patients of ILDs (n = 239) attending the outdoor and indoor Department of Respiratory Medicine, King George’s Medical University, India, for the duration of one year were subjected to transthoracic echocardiography along with measurement of serum pro-B-type natriuretic peptide (BNP) and troponin T values. The data were analyzed using the different definitions, and the prevalence was compared. Result. Incidence of pulmonary hypertension among ILD patients at mPAP cutoff ≥ 25 was 28.9%, while that at value ≥20 mmHg, incidence of pulmonary hypertension increased to 46.0%. An increment of 15–20% in incidence of pulmonary hypertension was observed among different types of ILD when cutoff of mPAP was changed. Conclusion. The new definition helps in a significant increase in the detection of pulmonary hypertension, which certainly helps in earlier detection and better management of patients.
Ultrasound Guided Percutaneous Nephrolithotomy in Mesh-Repaired Incisional Hernia
Authors: Inanloo Seyed Hassan , Nikoobakht Mohammad Reza , Akhavizadegan Hamed , Karbakhsh Mojgan
Published: November 2021

Objectives. To describe our technique of percutaneous nephrolithotomy (PNL) in patients with mesh-repaired flank incisional hernia. Polypropylene mesh which is used for fascia strengthening in hernia repair elicits intense inflammatory reaction and the consequent fibrosis alters the characteristics of abdominal wall. Thus, prior history of flank hernia repair with mesh may result in percutaneous nephrolithotomy failure. Materials and Methods. Demographic data, renal stones characteristics, and any complication during surgery and follow-up of patients who were treated by PNL during 2011 to 2020 and had mesh in their flank region were collected. Results. Percutaneous nephrolithotomy was performed without any problem in 8 patients with guide of ultrasonography. Conclusion. Based on our experience, ultrasound-guided PNL is feasible and hypothetically superior to fluoroscopy in such circumstances.
Electromagnetic Scattering Analysis of the Sea Surface with Single Breaking Waves
Authors: Wang Jingjing , Guo Lixin , Wei Yiwen , Chai Shuirong , Li Ke , Wang Anqi
Published: November 2021

A new electromagnetic (EM) scattering model of the sea surface with single breaking waves is proposed based on the high-frequency method in this paper. At first, realistic breaking wave sequences are obtained by solving the fluid equations which are simplified. Then, the rough sea surface is established using the linear filtering method. A new wave model is obtained by combining breaking waves with rough sea surface using a 3D coordinate transformation. Finally, the EM scattering features of the sea surface with breaking waves are studied by using shooting and bouncing rays and the physical theory of diffraction (SBR-PTD). It is found that the structure that is similar to a dihedral corner reflector between the breaking wave and rough sea surface exhibits multiple scattering, which leads to the sea-spike phenomenon that the scattering result of horizontal (HH) polarization is larger than that of vertical (VV) polarization, especially at low-grazing-angle (LGA) incidents with upwind. The sea-spike phenomenon is also closely related to the location of strong scattering.
Oncological Outcomes in Patients with Appendicular Myxofibrosarcomas: A Retrospective Study
Authors: Lee Yonghoon , Guertin Michael P. , Summers Spencer , Conway Sheila A. , Al Maaieh Mothasem , Yechieli Raphael , Trent Jonathan , Rosenberg Andrew E. , Pretell-Mazzini Juan
Published: November 2021

Background. Myxofibrosarcoma (MFS) is notorious for its infiltrative growth pattern, making wide excisions difficult to achieve. Our objective was to assess the impact of surgical margins and other factors that affected rates of local recurrence (LR), distant metastasis (DM), and overall survival (OS) of individuals undergoing resection for MFS. Methods. We retrospectively reviewed the medical records of 209 patients with appendicular soft tissue sarcomas between January 2012 and June 2018. Of these, 29 patients (14%) were diagnosed with myxofibrosarcoma. These patients underwent a total of 33 resections. The pathological analyses were conducted by an experienced musculoskeletal (MSK) pathologist. Demographics data, operative details, adjuvant therapy, and oncological outcomes were assessed. Results. Of the 29 patients (33 resections), the overall LR rate was 24% (7/29) and the 2-year LR rate was 17% (5/29). Factors associated with negative oncological outcomes were as follows: tumor size ≤10 cm (2-year local recurrence-free rates (LRFRs), 65%; 95% CI, 44–86%;

p
=
0.02

) and positive surgical margins grouped with surgical margins ≤0.1 cm (hazard ratio (HR), 11.74; 95% CI, 1.41–97.74;

p
=
0.02

). Chemotherapy and radiotherapy together increased the 2-year LRFR (LRFR, 100%; 95% CI, 100%,

p
=
0.001

). Two-year DM and OS rates were 15% and 79%, respectively. Female gender was a predictor of distant metastasis. Local recurrence had a negative impact on overall survival. Intraoperative analysis of resection margin accuracy was 75% (12/16) when non-MSK pathologists were involved but 100% accurate (12/12) when analyzed by an MSK pathologist. Conclusion. Myxofibrosarcomas showed high LR rates after treatment. Close margins (≤0.1 cm) should be considered as a risk factor for LR, and LR is associated with negative overall survival. Neoadjuvant therapy in terms of combined chemotherapy and radiation therapy associates with decreased LR rates. If intraoperative assessment of margins is to be done, it should be performed by an experienced MSK pathologist.
Properties and Applications of the Modified Kies–Lomax Distribution with Estimation Methods
Authors: Alsubie Abdelaziz
Published: November 2021

The present study introduces a new three-parameter model called the modified Kies–Lomax (MKL) distribution to extend the Lomax distribution and increase its flexibility in modeling real-life data. The MKL distribution, due to its flexibility, provides left-skewed, symmetrical, right-skewed, and reversed-J shaped densities and increasing, unimodal, decreasing, and bathtub hazard rate shapes. The MKF density can be expressed as a linear mixture of Lomax densities. Some basic mathematical properties of the MKF model are derived. Its parameters are estimated via six estimation algorithms. We explore their performances using detailed simulation results, and the partial and overall ranks are provided for the measures of absolute biases, mean square errors, and mean relative errors to determine the best estimation method. The results show that the maximum product of spacings and maximum likelihood approaches are recommended to estimate the MKL parameters. Finally, the flexibility of the MKL distribution is checked using two real datasets, showing that it can provide close fit to both datasets as compared with other competing Lomax models. The three-parameter MKL model outperforms some four-parameter and five-parameter rival models.
Serum Vitamin D Level and Risk of Community-Acquired Pneumonia: A Case-Control Study
Authors: Liyanage Guwani , Kaneshapillai Anusha , Kanthasamy Suthesan
Published: November 2021

Introduction. Recent research has shown conflicting evidence on the connection between vitamin D deficiency and community-acquired pneumonia (CAP) in children. Thus, we hypothesized that vitamin D deficiency could be a risk factor for CAP. Methods. Hospitalized children between 2 and 60 months with physician-diagnosed, radiologically confirmed severe community-acquired pneumonia (CAP) were enrolled as cases. Age-matched controls were enrolled from immunization and weighing clinics. A blood sample was collected to assess serum 25-(OH)D concentration. Unconditional logistic regression was done to examine the independent association of vitamin D level with community-acquired pneumonia. Results. Seventy-four children (females: 68%) were included. Overall, 27% had vitamin D deficiency (<20 ng/mL) and 37.8% had insufficiency (20–29 ng/mL). The vitamin D level ranged from 8.67 to 46.2 ng/mL. There was no statistically significant difference in 25(OH)D levels in controls and cases (

p
=
0.694

). In unconditional logistic regression, 25(OH)D concentration was not a determinant of CAP (OR: 0.99, CI: 0.937–1.044,

p
=
0.689

). This lack of association remained after adjustment for age, gender, income, crowding, and exposure to passive smoke (OR: 0.99, CI: 0.937–1.065,

p
=
0.973

). Household income was significantly associated with CAP (OR: 0.11, 95% CI: 0.021–0.567,

p
=
0.008

). Conclusion. Two-thirds of the children with CAP had vitamin D deficiency/insufficiency. In comparison with healthy controls, vitamin D level was not a significant determinant of community-acquired pneumonia. It informs that further multisite research is required using more rigorous scientific methods for conclusive evidence on the relationship between vitamin D and CAP.
Study on Damage Evolution Model of Sandstone under Triaxial Loading and Postpeak Unloading Considering Nonlinear Behaviors
Authors: Zhou Tianbai , Qin Yueping , Cheng Jian , Zhang Xiaoyu , Ma Qiufeng
Published: November 2021

Conventional triaxial loading and unloading tests were carried out on sandstone samples in the Zigong area, of Sichuan Province, China. The changes in the elastic modulus of the unloading curves under different confining pressures were calculated, and the evolution law of the nonlinear properties of rock was analyzed. The results show that the rock is subjected to nonlinear damage during initial compaction, the elastic phase, destruction, and postpeak unloading. Moreover, the nonlinear behaviors of rock are restrained by the confining pressures. On this basis, a nonlinear stress-strain relationship affected by the average stress is proposed to describe nonlinear behaviors in the initial compaction stage. According to the test data, the evolution laws of various energies inside the rock during loading and unloading cycles are obtained. The results show that the external work is transformed into elastic energy and damage dissipated energy. Based on the energy analysis, the energy balance equation is established according to the law of energy conservation. By deriving the energy balance equation, the damage evolution equation of sandstone under triaxial loading is solved to establish a continuous constitutive model. The calculation results of the model are compared with the test results from two aspects of loading and postpeak unloading. The comparison results show that the proposed model, which reflects the whole stress-strain process and nonlinear properties of rock, could also describe the stress-strain relationship at the postpeak unloading stage to some extent.
The Responses of Injection Pressure and Fracture Width during Height Extension in Sand-Mud Interbed Reservoirs in the Dongsheng Gas Field
Authors: Wang Di , Wang Haibo , Li Fengxia , Chen Fuhu , Zhu Xinchun
Published: November 2021

The Dongsheng gas field is characterized by low porosity and low permeability. Its principal producing reservoir is the H-1 zone, belonging to the Lower Shihezi Formation. Sand is the main lithology in the H-1 zone, while mud interlayers are also well developed in a vertical direction. As a result, the reservoir is a sand-mud interbed, which brings difficulty to fracture height extension. In order to understand the process of fracture height growth in a sand-mud interbed reservoir and obtain the responses of injection pressure and fracture width during a hydraulic fracturing, a hydromechanical-coupled model is established. Mud interlayers are fully considered and a cohesive zone model is adopted to deal with fracture propagation. Numerical results show that the fracture extends quickly to the sand-mud interface after initiation and breaks through rather than propagating along the interfaces. Pressure and width both increase continuously when fracture propagates in the mud interlayer. High-viscosity and high-injection rates are helpful for the fracture to break through the mud interlayer, especially at an early period. When the mud interlayers are asymmetric, pressure and width fluctuate several times once fracture propagates inside and breaks through the mud interlayer. Perforations close to the thinner mud interlayer can increase the fracture width and reduce fracturing risks.
Prediction of Road Network Traffic State Using the NARX Neural Network
Authors: Song Ziwen , Sun Feng , Zhang Rongji , Du Yingcui , Li Chenchen
Published: November 2021

To provide reliable traffic information and more convenient visual feedback to traffic managers and travelers, we proposed a prediction model that combines a neural network and a Macroscopic Fundamental Diagram (MFD) for predicting the traffic state of regional road networks over long periods. The method is broadly divided into the following steps. To obtain the current traffic state of the road network, the traffic state efficiency index formula proposed in this paper is used to derive it, and the MFD of the current state is drawn by using the classification of the design speed and free flow speed of the classified road. Then, based on the collected data from the monitoring stations and the weighting formula of the grade roads, the problem of insufficient measured data is solved. Meanwhile, the prediction performance of NARX, LSTM, and GRU is experimentally compared with traffic prediction, and it is found that NARX NN can predict long-term flow and the prediction performance is slightly better than both LSTM and GRU models. Afterward, the predicted data from the four stations were integrated based on the classified road weighting formula. Finally, according to the traffic state classification interval, the traffic state of the road network for the next day is obtained from the current MFD, the predicted traffic flow, and the corresponding speed. The results indicate that the combination of the NARX NN with the MFD is an effective attempt to predict and describe the long-term traffic state at the macroscopic level.
The Complex Relations between Organization and Disorganization and Their Conceptual System
Authors: Wu Kun , Zhang Shan , Wu Tianqi
Published: November 2021

For improving and developing self‐organization theory in contemporary complex information systems theory, it is necessary to reinterpret related concepts and their relations and construct a conceptual system related to self‐organization theory. Based on the latest research results, this article specifically discusses concepts of organization and disorganization, static organization and dynamic organization, static disorganization and dynamic disorganization, organizing and disorganizing, self‐organization and other‐organization, self‐disorganization and other‐disorganization, and their relations. Further, it explores the mechanism of organization and disorganization, the compatibility of organization and disorganization, feedback and mutual other‐disorganization in interaction, constraint and freedom of organization and disorganization, complexity of restraint and external factors, and relations between “the good” and “the evil” in restraint and freedom. On this basis, a diagram of the conceptual system of organization and disorganization, including four levels and their relations, is presented.
An Empirical Study of Software Metrics Diversity for Cross-Project Defect Prediction
Authors: Zhong Yiwen , Song Kun , Lv ShengKai , He Peng
Published: November 2021

Cross-project defect prediction (CPDP) is a mainstream method estimating the most defect-prone components of software with limited historical data. Several studies investigate how software metrics are used and how modeling techniques influence prediction performance. However, the software’s metrics diversity impact on the predictor remains unclear. Thus, this paper aims to assess the impact of various metric sets on CPDP and investigate the feasibility of CPDP with hybrid metrics. Based on four software metrics types, we investigate the impact of various metric sets on CPDP in terms of F-measure and statistical methods. Then, we validate the dominant performance of CPDP with hybrid metrics. Finally, we further verify the CPDP-OSS feasibility built with three types of metrics (orient-object, semantic, and structural metrics) and challenge them against two current models. The experimental results suggest that the impact of different metric sets on the performance of CPDP is significantly distinct, with semantic and structural metrics performing better. Additionally, trials indicate that it is helpful for CPDP to increase the software’s metrics diversity appropriately, as the CPDP-OSS improvement is up to 53.8%. Finally, compared with two baseline methods, TCA+ and TDSelector, the optimized CPDP model is viable in practice, and the improvement rate is up to 50.6% and 25.7%, respectively.
Combined Metabolomics and Network Toxicology to Explore the Molecular Mechanism of Phytolacca acinose Roxb-Induced Hepatotoxicity in Zebrafish Larvae in Vivo
Authors: Cao Dan , Zhao Chongjun , Li Zhiqi , Fan Qiqi , Chen Meilin , Jiang Yangyu , Wang Haiyan , Ning Hanjun , Lin Ruichao , Li Jian
Published: November 2021

Phytolacca acinosa Roxb (PAR), a traditional Chinese medicine, has been widely used as a diuretic drug for a long period of time for the treatment edema, swelling, and sores. However, it has been reported that PAR might induce hepatotoxicity, while the mechanisms of its toxic effect are still unclear. In this study, network toxicology and metabolomic technique were applied to explore PAR-induced hepatotoxicity on zebrafish larvae. We evaluated the effect of PAR on the ultrastructure and the function of the liver, predictive targets, and pathways in network toxicology, apoptosis of liver cells by PCR and western blot, and metabolic profile by GC-MS. PAR causes liver injury, abnormal liver function, and apoptosis in zebrafish. The level of arachidonic acid in endogenous metabolites treated with PAR was significantly increased, leading to oxidative stress in vivo. Excessive ROS further activated the p53 signal pathway and caspase family, which were obtained from KEGG enrichment analysis of network toxicology. The gene levels of caspase-3, caspase-8, and caspase-9 were significantly increased by RT-PCR, and the level of Caps3 protein was also significantly up-regulated through western blot. PAR exposure results in the liver function abnormal amino acid metabolism disturbance and motivates hepatocyte apoptosis, furthermore leading to liver injury.
Application and Comparative Study of Optimization Algorithms in Financial Investment Portfolio Problems
Authors: Liu Shuai , Xiao Chenglin
Published: November 2021

Portfolio theory mainly studies how to optimize the allocation of assets under the premise of maximizing expected returns and minimizing investment risks. In view of the instability of the financial market, a diversified investment portfolio can help control the loss of the investment portfolio. In addition to paying attention to the safety and return of asset allocation, we cannot ignore the liquidity of assets, that is, their liquidity. Adding high-liquidity products to asset allocation, such as equity investment, can better control the financial cash flow in response to emergencies. One of the ways to make assets flow is to securitize assets and sell them to the market. In order to revitalize the stock assets, good investment efficiency is a necessary choice for financial investment. Various financial products and their derivatives continue to enter people’s vision. There are many financial products in reality, and optimizing the investment portfolio can bring high economic benefits. The purpose of this paper is to study the application of optimization algorithms in financial portfolio problems. (1) Monetary policy remains prudent and neutral. It is not easy to expect flooding, but flexibility is required in complex situations. (2) Financial resources are tilted towards innovation and transformation and capital markets, which is beneficial to the development of capital markets in the medium and long term. (3) Unblocking the transmission mechanism is conducive to lenient credit and tapping the wrong killing opportunities in private enterprise debt. (4) Banks and other financial institutions have moderate pressure to give benefits to entities, but in the long run, the interests of the two are consistent. (5) Finance risk prevention will continue, orderly breaking the rigid exchange and reshaping the financial structure and ecology. (6) The pace of opening up of the financial industry has accelerated, and the bond market investor structure has improved. In this paper, we establish different optimization schemes to compare and study the portfolio problem and then use MATLAB to solve the modeling and programming problem, calculate the highest return rate and the lowest risk value before and after optimization, and then make a comparative analysis to get a better optimization scheme. The results show that the genetic algorithm model is superior to the quadratic programming method in terms of risk control. The minimum risk of portfolio optimization through genetic algorithm has been reduced by about 40%, and the maximum return has increased by about 25%. The comprehensive optimization effect is better than the quadratic planning method and ultimately can obtain higher economic benefits. It can be seen that the optimization algorithm is of great significance for the comparative study of financial portfolio problems.
LncRNA PTPRG-AS1 Promotes the Metastasis of Hepatocellular Carcinoma by Enhancing YWHAG
Authors: Chen Gaoyang , Zhang Zhisheng , Li Yan , Wang Lu , Liu Yanqing
Published: November 2021

Objectives. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. LncRNA PTPRG-AS1 (PTPRG-AS1) has been confirmed to function as a regulator in various cancers, whose function during HCC tumorigenesis is still not clear now. Thus, we aim to dig out the biological function and its mechanisms of PTPRG-AS1 in HCC. Methods. PTPRG-AS1 relative expression in tissues and cells was detected and analyzed using real-time quantitative PCR (qRT-PCR). Subcellular distribution of PTPRG-AS1 was examined by FISH experiments. The effects of PTPRG-AS1 in the growth of HCC were studied by in vitro CCK-8 experiments, transwell invasion experiments, and in vivo xenograft tumor experiments. Dual-Luciferase reporter assay was performed to verify the interaction between PTPRG-AS1 and miR-199a-3p or miR-199a-3p and its target gene, YWHAG. Results. PTPRG-AS1 was upregulated in HCC tissues compared with adjacent normal tissues. We identified PTPRG-AS1 mainly localized in the cytoplasm of HCC cells. Downregulation of PTPRG-AS1 suppressed HCC progression, while overexpression of PTPRG-AS1 showed the opposite effects. Furthermore, PTPRG-AS1 served as a miR-199a-3p sponge and positively regulated YWHAG expression. Besides, PTPRG-AS1 could promote HCC through miR-199a-3p/YWHAG axis. Conclusions. Taken together, we demonstrated PTPRG-AS1 may serve as a ceRNA and reversely regulates the expression of miR-199a-3p, thus facilitating HCC tumorigenesis and metastasis, which is expected to provide new clues for the treatment of HCC.
Anthelmintic Potential of Medicinal Plants against Ancylostoma caninum
Authors: Ekawardhani Savira , Anggoro Utari T. , Krissanti Ita
Published: November 2021

Ancylostoma caninum is one of the most important hookworms in dogs. A study revealed that the prevalence of ancylostomiasis in Indonesia is relatively high. However, cases of persistent ancylostomiasis in dogs were reported, indicating the possibility of anthelmintic resistance. The aim of this review is to provide an overview of the anthelmintic potential of plants preclinically against A. caninum based on related research articles. This review retrieved 14 articles from 2001 to 2021 investigating 19 different plants. Momordica charantia, Diospyros anisandra, and Citrus aurantiifolia hold a promising prospect as anthelmintic against A. caninum. This review found aspects of those medicinal plants that need to be investigated deeper to improve our understanding of the matter. In vitro results in this review have not yet been tested in in vivo trials, which are essential in determining the efficacy and safety of the use of these medicinal plants and also to justify its clinical application.
Correlations of mRNA Levels among Efflux Transporters, Transcriptional Regulators, and Scaffold Proteins in Non-Small-Cell Lung Cancer
Authors: Zhang Xieyi , Liu Wangyang , Edaki Kazue , Nakazawa Yuta , Kamioka Hiroki , Fujita Atsushi , Onozato Ryoichi , Iijima Misa , Tsuchida Shigeru , Arai Takahiro , Fujita Yukiyoshi , Mizoi Kenta , Ogihara Takuo
Published: November 2021

Multidrug resistance (MDR) due to enhanced drug efflux activity of tumor cells can severely impact the efficacy of antitumor therapies. We recently showed that increased activity of the efflux transporter P-glycoprotein (P-gp) associated with activation of Snail transcriptional regulators may be mediated mainly by moesin in lung cancer cells. Here, we aimed to systematically evaluate the relationships among mRNA expression levels of efflux transporters (P-gp, breast cancer resistance protein (BCRP), and multidrug resistance-associated protein 2 (MRP2)), scaffold proteins (ezrin (Ezr), radixin (Rdx), and moesin (Msn); ERM proteins), and SNAI family members (Snail, Slug, and Smac) in clinical lung cancer and noncancer samples. We found high correlations between relative (cancer/noncancer) mRNA expression levels of Snail and Msn, Msn and P-gp, Slug and MRP2, and Smuc and BCRP. These findings support our previous conclusion that Snail regulates P-gp activity via Msn and further suggest that Slug and Smuc may contribute to the functional regulation of MRP2 and BCRP, respectively, in lung cancer cells. This trial is registered with UMIN000023923.
Bayesian Analysis of Trends in Utilization of Maternal Healthcare Services in Pakistan during 2006-2018
Authors: Feroze Navid , Ziad Muhammad Ajmal , Fayyaz Rabia , Gaba Yaé Ulrich
Published: November 2021

Objectives. This study is aimed at investigating the time trends and disparities in access to maternal healthcare in Pakistan using Bayesian models. Study Design. A longitudinal study from 2006 to 2018. Methods. The detailed analysis is based on the data from Pakistan Demographic and Health Survey (PDHS) conducted during 2006-2018. We have proposed Bayesian logistic regression models (BLRM) to investigate the trends of maternal healthcare in the country. Based on different goodness-of-fit criteria, the performance of proposed models has also been compared with repeatedly used classical logistic regression models (CLRM). Results. The results from the analysis suggested that BLRM perform better than CLRM. The access to antenatal healthcare increased from 61% to 86% during years 2006-18. The utilization of medication also improved from 44% in 2006 to 60% in 2018. Despite the improvements from 2006 to 2018, every three out of ten women were not protected against neonatal tetanus, neither delivered in the health facility place nor availed with the skilled health provider at the time of delivery during 2018. Similarly, two-fifth mothers did not received any skilled postnatal checkup within two days after delivery. Additionally, the likelihood of MHS provided to mothers is in favor of mothers with lower ages, lower birth orders, urban residences, higher education, higher wealth quintiles, and residents of Sindh and Punjab. Conclusions. The gaps in utilization of MHS in different socioeconomic groups of the society have not decreased significantly during 2006-2018. Any future maternal health initiative in the country should focus to reduce the observed disparities among different socioeconomic sectors of the society.
Sanse Powder Essential Oil Nanoemulsion Negatively Regulates TRPA1 by AMPK/mTOR Signaling in Synovitis: Knee Osteoarthritis Rat Model and Fibroblast-Like Synoviocyte Isolates
Authors: Li Mingchao , Zhang Li , Liu Zixiu , Zhang Li , Xing Runlin , Yin Songjiang , Li Xiaochen , Zhang Nongshan , Wang Peimin
Published: November 2021

Synovitis is the primary driving factor for the occurrence and development of knee osteoarthritis (KOA) and fibroblast-like synoviocytes (FLSs) and plays a crucial role during this process. Our previous works revealed that transient receptor potential ankyrin 1 (TRPA1) ion channels mediate the amplification of KOA synovitis. In recent years, essential oils have been proved to have blocking effect on transient receptor potential channels. Meanwhile, the therapeutic effect of Sanse Powder on KOA synovitis has been confirmed in clinical trials and basic studies; although, the mechanism remains unclear. In the present study, Sanse Powder essential oil nanoemulsion (SP-NEs) was prepared, and then chemical composition, physicochemical properties, and stability were investigated. Besides, both in MIA-induced KOA rats and in LPS-stimulated FLSs, we investigated whether SP-NES could alleviate KOA synovitis by interfering with AMP-activated protein kinase- (AMPK-) mammalian target of rapamycin (mTOR), an energy sensing pathway proved to negatively regulate the TRPA1. Our research shows that the top three substances in SP-NEs were tumerone, delta-cadinene, and Ar-tumerone, which accounted for 51.62% of the total, and should be considered as the main pharmacodynamic ingredient. Less inflammatory cell infiltration and type I collagen deposition were found in the synovial tissue of KOA rats treated with SP-NEs, as well as the downregulated expressions of interleukin (IL)-1β, IL-18, and TRPA1. Besides, SP-NEs increased the phosphorylation level of AMPK and decreased the phosphorylation level of mTOR in the KOA model, and SP-NEs also upregulated expressions of peroxisome proliferator-activated receptor-gamma (PPARγ) and PPARγ coactivator-1α and downstream signaling molecules of AMPK-mTOR in vivo and in vitro. To conclude, a kind of Chinese herbal medicine for external use which is effective in treating synovitis of KOA was extracted and prepared into essential oil nanoemulsion with stable properties in the present study. It may alleviate synovitis in experimental KOA through the negative regulation of TRPA1 by AMPK-mTOR signaling.
A Study of Piano Timbre Teaching in the Context of Artificial Intelligence Interaction
Authors: Wei Cui
Published: November 2021

This paper provides an in‐depth analysis and research on piano timbre teaching in the context of artificial intelligence interaction, a bold vision of piano teaching, proposes a feasible solution in terms of teaching modules in intelligent piano teaching for senior teachers, and proposes an implementation path for the integration of intelligent piano and piano teaching from the four main blocks of piano teaching. Based on the multiplicative harmonic model of monophonic signal, combined with the variability of timbre characteristics, an audio synthesis model with editable timbre is proposed, and the experimental results show that editing the timbre parameters in the model can realize timbre modification, and the synthesized timbre conforms to the piano timbre characteristics. Based on the timbre analysis and the timbre synthesis model, a piano timbre library generation system is designed. The detailed design of the software modules such as audio file reading and writing, audio information analysis, timbre parameter acquisition, timbre synthesis, and simulated performance is given. The system can generate piano timbre libraries of different qualities flexibly and meet the requirements of timbre realism. The teaching experiment designed for teaching practice from solo teaching, and the practice target is first‐year undergraduate students in the university, and the practice period is six weeks, and finally, the feasibility of intelligent piano teaching application is analysed by combining the experimental results. Through the teaching objectives, teaching content, and teaching methods, teaching environment reflects intelligent piano teaching to make up for the limitations of traditional piano teaching. Analyse the development trend of intelligent piano teaching in the context of artificial intelligence interaction, and explore the value of intelligent piano teaching.
Fetal Malnutrition and Associated Factors among Term Newborn Babies at Birth in South Gondar Zone Hospitals, Northwest Ethiopia
Authors: Tesfa Desalegn , Teshome Fentaw , Ambaw Birhanie
Published: November 2021

Background. Undernutrition contributes to almost half of all under-five deaths. Fetal malnutrition (FM) has been implicated in both short- and long-term consequences among fetal, neonatal, and adult life. Currently, Ethiopia lacks information on the prevalence of fetal malnutrition and its associated factors. This study, therefore, is aimed at assessing the prevalence of FM at birth and its associated factors in South Gondar zone hospitals, northwest Ethiopia. Methods. A cross-sectional study was carried out from November 1, 2019, to April 30, 2020, among four hospitals of South Gondar zone. All women with their live newborns who met the eligibility criteria were included. Clinical assessment of nutritional status including other anthropometric measurements was done immediately after delivery. The newborn was declared as fetal malnourished if the clinical assessment of nutritional status cut-off point is less than 25. Data were collected by trained clinical midwives. Besides bivariate regression analysis, a multivariable logistic regression analysis was done to identify associations. Results. A total of 1592 mothers with their live newborns participated in this study. The prevalence of fetal malnutrition was 21.7% (95% CI: 19.7-23.9). Intimate partner violence (AOR: 1.97, 95% CI: 1.52-2.56), placental weight less than 512 grams (AOR: 2.76, 95% CI: 2.13-3.57), and small for gestational age (AOR: 1.96, 95% CI: 1.46-2.62) were significantly associated with fetal malnutrition. Conclusions. The prevalence of fetal malnutrition was a public health problem in this study. Intimate partner violence, placental weight, and small for gestational age were found the most significant variables. To avert fetal malnutrition, positive family relation and additional or balanced nutritional supplementation during pregnancy are critical. We recommend researchers do clinical follow-up research which comprises a detailed investigation of placental, maternal, and fetal factors including genes.
Alkannin Inhibits the Development of Ovarian Cancer by Affecting miR-4461
Authors: Wang Yaowen , Zhang Jingfang , Wang Feipeng , Chen Wenping , Ma Jie , Wang Honggang
Published: November 2021

Background. Previous studies have shown that alkannin has anticancer, anti-inflammatory, and antibacterial effects. However, the effect of alkannin in the development of ovarian cancer (OC) remains unknown. Therefore, this study aims to elucidate the function of alkannin in OC progression. Methods. RT-qPCR and western blot analysis were used to measure mRNA and protein expression. Cell viability and metastasis were detected by the CCK-8 assay, flow cytometry analysis, and transwell assay. Results. Alkannin had no cytotoxicity toward normal ovarian cells, but alkannin can inhibit cell proliferation and induce apoptosis in OC cells. In addition, alkannin inhibited cell migration and invasion and blocked EMT in OC. Besides, upregulation of miR-4461 was found in OC tissues and cells, which was regulated by alkannin. More importantly, miR-4461 can inverse the effects of alkannin on cell viability and metastasis in OC cells. Conclusion. Alkannin restrains cell viability, metastasis, and EMT in OC by downregulating miR-4461 expression.
Aberrant Brain Functional Connectivity Strength and Effective Connectivity in Patients with Type 2 Diabetes Mellitus
Authors: Guo Xi , Wang Su , Chen Yu-Chen , Wei Heng-Le , Zhou Gang-Ping , Yu Yu-Sheng , Yin Xindao , Wang Kun , Zhang Hong
Published: November 2021

Alterations of brain functional connectivity in patients with type 2 diabetes mellitus (T2DM) have been reported by resting-state functional magnetic resonance imaging studies, but the underlying precise neuropathological mechanism remains unclear. This study is aimed at investigating the implicit alterations of functional connections in T2DM by integrating functional connectivity strength (FCS) and Granger causality analysis (GCA) and further exploring their associations with clinical characteristics. Sixty T2DM patients and thirty-three sex-, age-, and education-matched healthy controls (HC) were recruited. Global FCS analysis of resting-state functional magnetic resonance imaging was performed to explore seed regions with significant differences between the two groups; then, GCA was applied to detect directional effective connectivity (EC) between the seeds and other brain regions. Correlations of EC with clinical variables were further explored in T2DM patients. Compared with HC, T2DM patients showed lower FCS in the bilateral fusiform gyrus, right superior frontal gyrus (SFG), and right postcentral gyrus, but higher FCS in the right supplementary motor area (SMA). Moreover, altered directional EC was found between the left fusiform gyrus and bilateral lingual gyrus and right medial frontal gyrus (MFG), as well as between the right SFG and bilateral frontal regions. In addition, triglyceride, insulin, and plasma glucose levels were correlated with the abnormal EC of the left fusiform, while disease duration and cognitive function were associated with the abnormal EC of the right SFG in T2DM patients. These results suggest that T2DM patients show aberrant brain function connectivity strength and effective connectivity which is associated with the diabetes-related metabolic characteristics, disease duration, and cognitive function, providing further insights into the complex neural basis of diabetes.
Intelligent Analysis of Core Identification Based on Intelligent Algorithm of Core Identification
Authors: Zhu Xiaolin , Lv Wei
Published: November 2021

The communication recognition of mobile phone core is a test of the development of machine vision. The size of mobile phone core is very small, so it is difficult to identify small defects. Based on the in-depth study of the algorithm, combined with the actual needs of core identification, this paper improves the algorithm and proposes an intelligent algorithm suitable for core identification. In addition, according to the actual needs of core wire recognition, this paper makes an intelligent analysis of the core wire recognition process. In addition, this paper improves the traditional communication image recognition algorithm and analyzes the data of the recognition algorithm according to the shape and image characteristics of the mobile phone core. Finally, after constructing the functional structure of the system model constructed in this paper, the system model is verified and analyzed, and on this basis, the performance of the improved core recognition algorithm proposed in this paper is verified and analyzed. From the results of online monitoring and recognition, the statistical accuracy of mobile phone core video recognition is about 90%, which has higher accuracy in mobile phone core image recognition than traditional recognition algorithms. The core line recognition algorithm based on deep learning and machine vision is effective and has a good practical effect.
Brucellosis in Camels and Humans: Seroprevalence and Associated Risk Factors in Amibara District of Afar Region, Ethiopia
Authors: Wegi Fekadu Gutema , Amenu Kebede , Chalchisa Adugna , Mamo Gezahegne
Published: November 2021

Brucellosis is an important neglected zoonotic disease caused by infection with bacteria of the genus Brucella affecting different mammalian species including humans. A cross-sectional study was conducted to estimate the seroprevalence of brucellosis in camels and humans and its associated risk factors in Amibara District of Afar Region in Northeast Ethiopia, from October 2019 to May 2020. A total of 250 camel and 120 human sera were serially tested using the Rose Bengal plate test (RBPT) and complement fixation test (CFT). The overall seroprevalence of camel brucellosis in this study was 7.6% (95% CI: 4.9–11.56) by RBPT and 3.2% (95% CI: 1.63–6.2) by combined RBPT and CFT. In humans, twelve (10%) of the collected sera were positive by RBPT among which only four of them (3.33%) were positive by CFT. The risk factor analysis indicated that age, body condition, number of parity, and abortion history were significantly associated with Brucella seropositivity in camel (P ≤ 0.05). In humans, occupation and nonprotective handling of dystocia cases showed an apparent association with Brucella seropositivity. The results of this study indicated that brucellosis is a common health problem in camels and humans in Amibara District of Afar Region. The public health importance of this disease is associated with raw milk consumption and close contact with the animals having history of recent abortion. Therefore, controlling the risk factors, establishing Brucella diagnostic service in human clinics and hospitals, continuous social training with feedback assessments, and overall implementing of One Health approach framework to attain optimal health for people and domestic animals in area are recommended to safeguard the health of society.
A Study of Instantaneous Shear Mechanical Properties on the Discontinuity of Rock Mass Based on 3D Morphological Properties
Authors: Zhang Qingzhao , Luo Zejun , Jang Bo-An , Wang Qiuyi , Zhong Zhen , Jiang He
Published: November 2021

In order to study the instantaneous mechanical properties of rock mass discontinuities with different 3D morphologies during the shear process, the Brazilian splitting method is used to prepare natural rock mass discontinuities, and the high-precision 3D scanning test of discontinuities is carried out. The

Z

2

is selected as the evaluation parameter of the discontinuities. Based on the graded cyclic shear test results of discontinuities, the influence of the morphology characteristics on the strength and deformation characteristics is analyzed. With the increase of shear times, the 3D morphology characteristic parameters of the structural plane decrease steadily after the graded cyclic shear. Based on the test curve, the graded cyclic shear characteristics of rock mass discontinuities are analyzed from the shear deformation, and the shear process of the discontinuities is finely divided by combining with the variation characteristics of shear stiffness. Combined with the 3D morphology parameters, an empirical formula for the shear strength of discontinuities is proposed. Through verification, the effect of the new model is better than that of the classical JRC-JCS model.