bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Efficiency of Preparations Based on Medical Plant Raw Materials in the Treatment of Urolithiasis
Authors: Н. А. Цубанова  , О. В. Барська  , Е. С. Чернявські
Published: September 2019

The article provides an overview of scientific publications on preclinical and clinical research. plant extracts of highlander grass (Polygonum aviculare L .), birch leaves (Betula pendula Roth. (B. Verrucose Ehrh.), Rhizomes of creeping creeper (Agropyron repens L .), parsley root (Petroselinum crispum), grass of horsetail (Equisetum arvense L .), roots of lovage (Levisticum officinale L .), herbs of goldenrod (Solidago virgaurea L .) are part of the naturopathic preparation Fitolysin Nefrokapsuly (Pharmaceutical Plant Polfarma SA). Overview contains generalized results and estimates of accumulated scientific material on studied data phytopreparations. The expediency of using «Fitolysin Nefrokapsuly» in the treatment of urolithiasis has been substantiated.
Integrated Assessment of the Quality of Medical Care at the Primary Level in Patients with Chronic Dermatoses by General Practitioners-family Medicine
Authors: Л. В. Черкашина
Published: September 2019

With the use of information-entropy analysis, an integrated quality assessment (IEC) of medical care for patients with chronic dermatosis (CD) was performed by general practitioners-family medicine. It is proved that the level of adequacy of the clinical and anamnestic examination for CD varies from 62.7±4.3% to 59.1±3.6%, and the IEC of this component of the diagnostic process is in the range of 3.543÷4.349 bytes with an improvement reserve without additional material costs (due to the standardization of anamnestic examination). It was determined that the adequacy of the use of clinical and laboratory examination of patients with CHD ranges from 58.3±4.4% to 68.0±5.3% if there are reserves of improvement, primarily due to simple and accessible for primary care laboratory diagnostic procedures. It has been demonstrated that pharmacotherapeutic correction has the greatest contribution to IPO in CD: with psoriatic disease – 60.5±3.4%, with chronic eczema – 53.9±2.3%, while the use of non-medicaments in the period between exacerbations of CD remains additional reserve of improvement of medical care at the primary level of its provision.
Past Experience in the Formation Communication Skills of Future Doctors: «Knowing the Past a Doctor Should to Foresights the Future»
Authors: О. О. Воронцов  , Л. С. Бабінець
Published: September 2019

The article is dedicated to the experience of forming and strengthening the motivation of future specialists in the field of primary health care, prevention and rehabilitation through the formation and using of topical content of aphorisms of the great philosophers and doctors of ancient times. The urgency and scale of the problems of reforming the medical sector and medical education persist for many years. The latest high-tech and expensive methods of teaching are supplemented by classical teaching methods with the appropriate professional level of scientific and pedagogical teams. Professional success, in addition to knowledge, skills and clinical skills, is based on the communicative skills that highlight the attitude of the future doctor to the chosen profession. It’s not necessary to look for new words to prove the role of communication skills. Specially selected statements of the most authoritative specialist – the ancient Greek physician Hippocrates, which were exhaustively formulated in the fourth century BC, amaze by their persuasiveness. We recommend to use the topical content of the aphorisms of the great doctors and philosophers as an additional pedagogical method for optimizing the training of students to perform their practical work in the clinic.
Obesity and Arterial Hypertension: Modern View on Pathogenesis, Diagnosis and Treatment
Authors: О. Ю. Горопко
Published: September 2019

The article deals with questions of pathogenesis of obesity and hypertension, features of fat metabolism, anthropometric and morphometric examination by bioelectric impedance analysis method in patients with arterial hypertension and obesity.
Difficult Differential Diagnosis of Hemorrhagic Vasculitis in the Practice of General Physician-family Practitioner: Own Clinical Observations and Literature Data
Authors: А. М. Пілецький  , Н. В. Снігир  , В. М. Рудіченко  , В. О. Кривець  , М. Г. Маслій
Published: September 2019

The article is dedicated to the problem of differential diagnosis of hemorrhagic vasculitis on the level of primary medicine. Current classification of systemic vasculitides, namely International Chapel Hill Consensus Conference of 2012 is present. Clinical features of the often form of vasculitis – Henoch-Schönlein purpura and the less common form of vasculitis of the small vessels – leukocytoclastic vasculitis (hypersensitivity vasculitis) are analyzed. Material is given basing on scientific literature data and own clinical observations of skin vasculitis.
Clinical Approaches to Therapy of Arterial Hypertension in Women’s Postmenopaceus
Authors: В. М. Ждан  , Є. М. Кітура  , О. Є. Кітура  , М. Ю. Бабаніна  , М. В. Ткаченко
Published: September 2019

The problem of hypertension in females is becoming increasingly urgent, since more than half of women over the age of 60 is recording steady increase in blood pressure (BP). At the same time, the effectiveness of antihypertensive therapy (AGT) in women after 50 years is reduced. The article presents the main features of the course of arterial hypertension in women in the postmenopausal period, as well as the features of antihypertensive therapy.
Methodical, Diagnostic and Prognostic Aspects Using Transmitral Blood Flow Indicators as Markers of Diastolic Dysfunction During the Progression of Chronic Heart Failure
Authors: О. С. Коміссарова  , Г. П. Сябренко  , С. Х. Салех Нажар  , Г. М. Сухомлин
Published: September 2019

The objective: to evaluate changes in transmitral blood flow indices asmarkers of myocardial diastolic function using Doppler echocardiography with an increase in the severity of chronic heart failure (CHF).Materials and methods. 84 patients with CHF II-III FC were examined. Evaluation of left ventricular (LV) diastolic function was carried out by the Doppler-echocardiography method in pulsed mode on a Toshiba SSH-160A apparatus (Japan) using a 3.5 MHz transducer based on transmitral diastolic blood flow.Results. The analysis showed that if in patients with CHF II FC,LV myocardial hypertrophy dominates in the pathogenesis, then in patients with CHF III FC there is systolic dysfunction. The main pathogenetic factor in the increase in the severity of CHF from II to III FC is diastolic dysfunction.Conclusion. In patients with CHF II FC in an intact left atrium, impaired transmitral diastolic blood flow occurs in the «slow relaxation» mode. Patients with CHF II FC against the background of an increased size of the left atrium, especially in the presence of post-infarction cardiosclerosis and arrhythmias, are diagnosed with a «pseudonormal» type of transmitral blood flow. The majority of patients with CHF III FC are diagnosed with a «restrictive» type of transmitral blood flow.
Reproductive Health of Women with the Combined Pathology of Uterus and Mammary Glands
Authors: О. А. Полюлях
Published: September 2019

The objective: depression of disturbances of reproductive function and gestational complications at women with combined pathology of uterus and mammary glands on the basis of studying of new aspects of pathogenesis of sterility and development of obstetric and perinatal pathology, and also improvement and introduction of algorithm of diagnostic and treatment-and-prophylactic actions depending on options of the combined pathology of uterus and mammary glands.Materials and methods. Sterility treatment at all patients at 1 stage was carried out by use of auxiliary reproductive technologies. 1 group was made by 90 women with diffuse diplasya of mammary glands. Three subgroups were distinguished from them taking into account existence of accompanying genital pathology. At the 2nd stage of researches by us it was carried out complex clinical-laboratory and functional inspection 210 women who depending on existence of the combined pathology of uterus and mammary glands were divided into groups and subgroups. In complex of the conducted researches were included clinical, ekhografical, dopplerometrical, cardiotocografical, morphological, endocrinological, biochemical and statistical.Results. Use of algorithm of diagnostic and treatmentand-prophylactic actions allows to reduce the frequency of spontaneous abortion by 4.5%; premature births – for 3.3%; placental dysfunction – for 14.3%; preeclampsias – for 7.8%; anomalies of patrimonial activity – for 11.1%; fetus distress – for 7.8%; the cesaraen sections – for 10.0%; asphyxias of newborns of average degree – for 14.8%; the serious – for 7.3%; post-hypoxemic encephalopathy – for 7.3%; realization of fetal becoming infected – for 6.8% and perinatal losses – for 3.5% respectively.Conclusion. Use of advanced algorithm of treatment-and-prophylactic actions at women with the combined pathology of uterus and mammary glands allows to reduce significantly frequency not reproductive losses, but also obstetric and perinatal complications that is the solution of an important problem of modern obstetrics.
Systemic Lupus erythematosus and Multiple Sclerosis: Two Diseases or One?
Authors: Л. В. Хіміон  , І. В. Климась
Published: September 2019

The article described modern literature data on the diagnosis of the nervous system lesions in patients with systemic lupus erythematosus. There described the differential diagnosis of neurolupus and multiple sclerosis. There described common features and differences of manifestations of the nervous system lesions in patients with systemic lupus erythematosus and multiple sclerosis, as well as the treatment strategy of both diseases. Additionally, we described own data from two observable clinical cases. One of which demonstrates the clinical and diagnostic similarity of neurolupus and multiple sclerosis. The second clinical case shows the possibility of combining the two described diseases in one patient.
Anxiety Disorders in General Practice
Authors: Л. А. Дзяк  , О. С. Цуркаленко
Published: September 2019

Anxiety disorders are a variant of borderline mental pathology belonging to the group of neurotic disorders, that is, to psychogenically caused by painful conditions characterized by a variety of clinical manifestations. Timely diagnosis and early start of adequate treatment of anxiety spectrum disorders can significantly improve the quality of life of patients.The article discusses the phenomenological aspects of anxiety disorders, especially the diagnosis and treatment in the general medical network, in particular, the currently recommended regimens for using the drug Eglonil and the advantages of this drug are described. Eglonil demonstrates the possibility of widespread use in various types of anxiety disorders, which gives the drug a special status among other psychotropic compounds.
Chronotropic Incompetence As Pathophysiological Mechanism Reduction of Exercise Tolerance in Patients with Arterial Hypertension and Clinical Signs of Heart Failure with Preserved Left Ventricular Ejection Fraction
Authors: К. М. Амосова  , О. В. Василенко  , Ю. В. Руденко  , А. Б. Безродний  , Г. В. Мостбауер  , К. І. Черняєва  , К. П. Лазарєва  , І. В. Прудкий  , І. І. Бурлаченко  , Ю. О. Сиченко  , А. В. Саблін  , Н. В. Мельніченко
Published: September 2019

The objective: to determine the contribution of chronotropic incompetence (CI) , as one of the mechanisms for reducing exercise tolerance (ET) in patients with heart failure and preserved ejection fraction (HFpEF) of the left ventricle (LV).Materials and methods. AT prospective study we consistently enrolled 39 patients with hypertension in conjunction with clinical signs and symptoms of heart failure, left ventricular ejection fraction ≥ 50% and symptoms of DD according to Doppler ECG, and compared with 30 patients with heart failure and LVEF 40–49%. Patients were determined level of NTproBNP, except standard laboratory indicators. Pulsed wave velocity (carotid-femoral) was determined using aplanation tonometry Using ECG, standard indicators were determined, and a diastolic stress test was performed when determining the E/e’ index in the range of 9–13. According to the levels of NTproBNP and LVEF patients were divided into three groups. Group 1 with NTproBNP level less than 125 pg/ml included 11 to group 2 (NTproBNP ≥125 pg/ml) – 28 to a group of 3–30 patients.Results. According to the test results of diastolic stress test, 72,7% of patients group 1 achieved submaximal heart rate compared to 39,2% in group 2 and 10% in group 3 (p<0,05 and p<0,01). Time of work and executed load in patients of group 1 were higher compared to groups 2 and 3 (p<0,05 and p<0,01). Assessing the heart rate at an intermediate stage (50 W), there was a statistical difference between patients in groups 1 and 2 (p<0,01). CI and double product at the peak of exercise in patients of group 1 higher than in patients of groups 2 and 3 (p<0,01), according to comparable values of 2 and 3 groups. According to the results of the correlation analysis, these indicators in patients of group 2 correlated directly with the load performed (r=0,665; p<0,01 and r=0,665; p<0,02) and the load time (r=0,587; p<0,01 and r=0,477; p<0,01) and DT – with the time of the work performed (r=0,435; p<0,01). E/e’ with exercise inversely correlated with the load performed (r=–0,419; p<0.01).Conclusions. In patients with hypertension signs of HF and preserved LV EF with a NTproBNP level ≥125 pg/ml, the value of chronotropic reserve and double work at maximum exercise is less than those with NTproBNP level <125 pg/ml and comparable to those in patients with HF with intermediate (40–49%) LV EF. Patients with hypertension symptoms of heart failure with preserved ejection fraction with a level NTproBNP ≥125 pg/ml value of chronotropic reserve and double product at peak of exercise directly proportionally correlated to the applied load and operating time, and E/E’ at exercise inversely correlated with the performance of the load.
Nonspecific Ulcerative Colitis in Practice of Family Doctor
Authors: Л. В. Хіміон  , С. В. Данилюк  , Н. В. Кіча  , Т. М. Будько
Published: September 2019

The article presents the main diagnostic criterias and management of patients with ulcerative colitis in the conditions of primary care. An algorithm has been formulated for the action of the general practitioner-family doctor in the diagnosis and treatment of this category of patients.
A New Index of Comorbidity in Patients with Non-alcoholic Fatty Liver Disease on the Background of Diabetes Mellitus and Concomitant Hypothyroidism
Authors: С. В. Фейса  , І. В. Чопей
Published: September 2019

The objective: to study the informativeness of the use of well-known comorbidity indices for assessing the status of patients with nonalcoholic fatty liver disease (NADH) and associated pathology, to substantiate the feasibility of developing and applying a new method for such patients.Materials and methods. 114 patients with NAFLD on type 2 diabetes mellitus background were been examed, the concomitant hypothyroidism were diagnosed in 47 of them (32 – subclinical, 15 – clinically expressed). The clinical severity of diseases was been evaluated using Charlson index, Caplan-Feinstein index, CIRS system, and a new Comorbidity Index (CI).Results. The benefits of Comorbidity Index (IVPKZ) are possibility of assessing the presence such diseases: non-alcoholic fatty liver disease, concomitant thyroid dysfunction, anemia and dyslipidemia. It makes possible to correct the patient’s management, taking into account the dominant concomitant diseases and cardiovascular risk.Conclusions. The index of the severity of the course of comorbid diseases can be used in practical medicine to assess the severity of the concomitant pathology in patients with diabetes mellitus.
Determination of Urinary Lithogenic Factors for Predicting Complications with Contact Ureterolitotripsy in Persons with Single Kidney
Authors: О. Л. Мороз
Published: September 2019

The aim of the study was to increase the effectiveness of the results of minimally invasive treatment in patients with single kidney ureterolithiasis by determining the salt profiles in the urine of patients. Patients with a single kidney tend to form calculous recurrence, and the determination of bacteriuria and urine pH with certain parameters of the exchange of prolitogenic substances is a relevant diagnostic measure, which at the preoperative stage can make it possible to predict the effectiveness of treatment after minimally invasive ureterolithotripsy techniques.
The Study of the Effect of Low Doses of Androgens on the Ovarian Reserve, Biochemical and Hormonal Parameters
Authors: Г. В. Стрелко
Published: September 2019

The objective: justification of the use of low doses of androgens in women with a reduced ovarian reserve. Study of the safety and effectiveness of their use in laboratory experiments involving laboratory animals.Materials and methods. Specific efficacy has been investigated in repeated doses of Dehydroepiandrosterone (DHEA) for 90 days in female Wistar rats. The drug was administered in therapeutic and triple therapeutic doses. Biochemical and hormonal indices were studied. A histological examination of female ovaries after a treatment cycle was also conducted.Results. There were no significant changes in haematological parameters when using a therapeutic and three-fold dose; none of them exceeded the norm, which indicates the safety of prescribing drugs and the absence of adverse effects on hematological parameters. In the study of biochemical parameters of peripheral blood, one can notice a slight increase in glucose, creatinine and alkaline phosphatase levels in the group that used a three-dose dose, and, nevertheless, they did not go beyond the norm. Morphological and histological changes in ovaries of rats indicate an increase in the number of follicles at all stages of development; the effect was dose-depending.Conclusion. Thus, the use of therapeutic doses of the drug can be considered completely safe. The results of the study may be useful in the development of therapeutic approaches in women with a reduced ovarian reserve.
Application of Native Plasma to the Treatment of Knee Joint Injury
Authors: Г. О. Гаврилюк
Published: September 2019

One of the most common injuries in the structure of joint injuries is trauma of the knee joint, which is largely due to its anatomical features. At the present stage of a knee joint injury treating, as a rule, is the use of surgical methods of correction. However, even surgical intervention is not a guarantee of complete recovery of such patients.The objective: to investigate the efficacy and safety of PAP as part of integrated treatment early in the post-traumatic knee joint surgery in younger patients compared with standard treatment.Materials and methods. The study was conducted on the basis of the KZ KOR «Kyiv Regional Clinical Hospital» and included 60 patients in the early post-traumatic period of the knee joint. The patients were divided into two groups. All patients included in the study received standard treatment (NSAIDs, complex physiotherapy) for 10 days. In agreement with the patients, 30 patients (Gr.1) received 3 intraarticular injections of PAP in addition to standard treatment. Within each group, the patients did not differ significantly in their age, sex, and duration of the disease. All patients included in the study had a comprehensive clinical and laboratory examination before treatment, after 2 and 4 weeks, as well as 6 and 12 months.Results. During the treatment period, the patients of both groups showed a positive result both in the general index of KOOS and in the indices of all subscales, with statistically significant differences between the groups. Moreover, the most revealing changes in each group were for the two subchalates – sport and activity on rest and assessment of quality of life. The analysis of the safety of complex therapy with the use of PAP in the form of intra-articular injections in knee joint injuries did not reveal any case of development of undesirable events, except for a temporary painful sensation at the injection site.Conclusions. The use of PAP in the treatment of knee joint injuries reduce pain, stiffness, improves the function of the knee joint, and also reduces the need for use of NSAIDs.
Thinking on the Poisson-esque simple differential equations using the elementary symmetric polynomial differential operators
Authors: Tahara Hiroki
Published: September 2019

本稿では、多変数関数に対する各変数の一階偏微分作用素の基本対称式として定義される作用素に関して、それを用いたPoisson方程式と似た極めて単純なかたちで定義される微分方程式を提唱し、それについていろいろ考える。
An Accurate Solution for Credit Valuation Adjustment (CVA) and Wrong Way Risk
Authors: Xiao Tim
Published: September 2019

This paper presents a Least Square Monte Carlo approach for accurately calculating credit value adjustment (CVA). In contrast to previous studies, the model relies on the probability distribution of a default time/jump rather than the default time itself, as the default time is usually inaccessible. As such, the model can achieve a high order of accuracy with a relatively easy implementation. We find that the valuation of a defaultable derivative is normally determined via backward induction when their payoffs could be positive or negative. Moreover, the model can naturally capture wrong or right way risk. https://arabixiv.org/2cqbg/download
An Accurate Solution for Credit Valuation Adjustment (CVA) and Wrong Way Risk
Authors: Xiao Tim
Published: September 2019

This paper presents a Least Square Monte Carlo approach for accurately calculating credit value adjustment (CVA). In contrast to previous studies, the model relies on the probability distribution of a default time/jump rather than the default time itself, as the default time is usually inaccessible. As such, the model can achieve a high order of accuracy with a relatively easy implementation. We find that the valuation of a defaultable derivative is normally determined via backward induction when their payoffs could be positive or negative. Moreover, the model can naturally capture wrong or right way risk. https://frenxiv.org/2rtya/download
Karakteristik sistem aliran sungai bawah tanah di kawasan Karst Jonggrangan dengan tracer test
Authors: Adji Tjahyo Nugroho , Agniy Romza Fauzan , Cahyadi Ahmad , Haryono Eko , Nurkholis Afid
Published: September 2019

Karakteristik hidrogeologi bawah permukaan di kawasan karst penting untukdiketahui guna mendukung pengelolaan sumber daya airnya. Namun demikian, lorong-lorongperguaan di daerah karst tidak semuanya dapat diakses karena berbagai kendala sepertipenyempitan lorong yang mengakibatkan manusia tidak dapat memasukinya serta adanyalorong gua yang penuh dengan air sehingga pendefinisian sistem hidrogeologi bawahpermukaan karst sulit untuk dilakukan. Penelitian ini dilakukan di 3 lokasi yang terletak diKawasan Karst Jonggrangan, Kabupaten Kulon Progo (Jawa Tengah) dan KabupatenPurworejo (DIY). Lokasi yang dikaji adalah Mata air Mudal, Gua Kiskendo, dan Gua Anjani.Tujuan penelitian ini adalah : (1) Mengetahui sistem aliran bawah permukaan di 3 lokasitersebut; dan (2) Menganalisis kurva hasil uji tracer di 3 lokasi tersebut. Metode yangdigunakan pada penelitian ini menggunakan metode survai yang terbagi dalam beberapa tahapmeliputi tahap persiapan, tahap kerja lapangan, dan tahap pasca lapangan. Tahap persiapanmeliputi pemilihan lokasi penelitian dan pemilihan lokasi untuk dilakukan injeksi zat tracer.Tahap kerja lapangan meliputi pemasangan fluorometer di 3 lokasi penelitian, serta injeksi zattracer. Tahap pasca lapangan adalah analisis hidrokemograf uji tracer. Hasil penelitianmenunjukkan bahwa : (1) terdapat konektivitas aliran bawahtanah antara gua-gua disekitar 3lokasi penelitian, yakni sistem Kali Cebong-Anjani dan Jumbleng Sawah – Anjani, sistem GuaSemar – Gua Kiskendo, sistem Gua Nguwik – Mata air Mudal. Hasil uji tracer menunjukkansingle peak di 3 lokasi penelitian yang mencerminkan bahwa tidak adanya cabang aliran darilokasi penuangan zat perunut hingga lokasi pemantauan. Karakteristik lain yang mampudianalisis dari hasil uji tracer antara lain time of first detection, time to peak, maximumconcentration, distance, dan peak velocity.
Credit Valuation Adjustment Study
Authors: Xiao Tim
Published: September 2019

This paper presents a model for calculating credit value adjustment (CVA) by taking wrong way risk into account. Many people believe that the cash flows of a defaultable financial contract can be priced independently and then be summed up to give the final risky price of the contract. We emphasize here that this conclusion is only true of the financial contracts whose payoffs are always positive. In the cases where the promised payoffs could be positive or negative, the valuation requires not only a backward recursive induction procedure, but also a strategic selection of different discount factors according to the market value in time. This coupled valuation process allows us to capture correlation between counterparties and market factors.
KARAKTERISTIK NEGARA INDONESIA
Authors: Siregar Ainun Mardiyah
Published: September 2019

salah satu yang menjadi karakteristik negara Indonesia dikenal dengan sebutan identitas negara Indonesia, yang dapat membedakannya dengan negara lain.
Belajar, Perguruan Tinggi, dan Tradisi Akademik: Melangkah ke Bangku Kuliah
Authors: Wekke Ismail Suardi
Published: September 2019

Artikel ini pengantar perkuliahan dalam mata kuliah bahasa Arab. Termasuk mengemukakan arah perjalanan perkuliahan dan juga hasil yang akan dicapai selama berlangsungnya perkuliahan. Bagian dari artikel, dikemukakan tradisi akademik dalam kaitan belajar di perguruan tinggi.
DATABASE KOMODITAS TEMBAKAU DAN PABRIK ROKOK DI KABUPATEN TULUNGAGUNG TAHUN 2012
Authors: Prabowo Rachmad Gesah Mukti
Published: September 2019

Maksud dari kegiatan Penyusunan Data Base Komoditi Tembakau dan Industri Rokok di Kabupaten Tulungagung ini adalah tersusunnya peta kawasan tembakau dan pabrik rokok sebagai acuan baku dalam perencanaan pengembangan tembakau rakyat dan industri rokok, serta kebijakan yang dapat berfungsi efektif dalam pembangunan perekonomian secara umum pada masa mendatang.
The neural representation of self is recapitulated in the brains of friends: A round-robin fMRI study
Authors: Chavez Robert , Wagner Dylan D.
Published: September 2019

Humans continually form and update impressions of each other’s identities based on the disclosure of thoughts, feelings, and beliefs. At the same time, individuals also have specific beliefs and knowledge about their own self-concept. Over a decade of social neuroscience research has shown that retrieving information about the self and about other persons recruits similar areas of the medial prefrontal cortex (MPFC), however it remains unclear if an individual’s neural representation of self is reflected in the brains of well-known others or if instead the two representations share no common relationship. Here we examined this question in a tight-knit network of friends as they engaged in a round-robin trait evaluation task in which each participant was both perceiver and target for every other participant and in addition also evaluated their self. Using functional magnetic resonance imaging and a multilevel modeling approach, we show that multivoxel brain activity patterns in the MPFC during a person’s self-referential thought are correlated with those of friends when thinking of that same person. Moreover, the similarity of neural self/other patterns was itself positively associated with the similarity of self/other trait judgments ratings as measured behaviorally in a separate session. These findings suggest that accuracy in person perception may be predicated on the degree to which the brain activity pattern associated with an individual thinking about their own self-concept is similarly reflected in the brains of others.
Citation counts and journal impact factors do not capture some indicators research quality in the behavioral and brain sciences
Authors: Dougherty Michael R , Horne Zachary
Published: September 2019

Citation data and journal impact factors are important components of faculty dossiers and figure prominently in both promotion decisions and assessments of a researcher's broader societal impact. Although these metrics play a large role in high-stakes decisions, the evidence is mixed about whether they are strongly correlated with indicators of research quality. We use data from a large-scale dataset comprising 45,144 journal articles with 667,208 statistical tests and data from 190 replication attempts to assess whether citation counts and impact factors predict three indicators of research quality: (1) the accuracy of statistical reporting, (2) the evidential value of the reported data, and (3) the replicability of a given experimental result. Both citation counts and impact factors were weak and inconsistent predictors of research quality, so defined, and sometimes negatively related to quality. Our findings raise the possibility that citation data and impact factors may be of limited utility in evaluating scientists and their research. We discuss the implications of these findings in light of current incentive structures and discuss alternative approaches to evaluating research.
There is No Meta-Analytic Evidence of Blueberries Improving Cognitive Performance or Mood
Authors: Brydges Christopher , Gaeta Laura
Published: September 2019

Submitted as a Letter to the Editor in Brain, Behavior, and Immunity
Screening for ovarian cancer: Evidences
Authors: Shrestha Binuma , Acharya Bijaya Chandra
Published: September 2019

Cancer of the ovary is a leading cause of death among women. Early stage disease are not evident for the incumbent nature of disease in the abdominal cavity. When ovarian cancer is detected and treated while it is still confined to the ovary (stage I), the 5-year survival rate is approximately 90%, but 33% when the disease is diagnosed at stage III or IV. So screening had role in down staging the disease and improve survival. Evidence still does not support screening in average risk women but annual gynecologic examination with pelvic examination is recommended for preventive healthcare. Screening in women with increased risk and inherited risk result in a decrease in the number of deaths in women. For women with mutations in BRCA2, ovarian cancer screening should be initiated between ages 35 and 40.
The Molecular Mechanisms of Human Osteosarcoma Cell Apoptosis Induced by Arsenic Trioxide and Vincristine
Authors: Yao Xiao-Guang , Zhang Wei-Hua , Zhao Gui-Song , Yao Jia-Chen , Wu Peng-Huan , Song Shu-Xia , Liu Su-Yuan , Arun Sigdel
Published: September 2019

Background: Arsenic trioxide (As2O3) and vincristine (VCR) have been used for the treatment of tumors. But little is known about the mechanisms and whether they induce apoptosis of human osteosarcoma MG-63 cells.

Methods: MG-63 cells were treated with As2O3 and VCR, respectively. Their effects on cell apoptosis and cell cycle arrest were evaluated by MTT assay and flow cytometry. Their effects on the expressions of apoptosis-related proteins PCNA, Bcl-2, Bax, caspase-3, cyclin D1 and cyclin E were investigated by Western-blot.

Results: Both As2O3 and VCR have time- and dose-dependent effects on apoptosis and cell arrest of MG-63 cells. As2O3 induces MG-63 cell arrest in S phase, whereas VCR induces MG-63 cell arrest in G2/M phase. Both As2O3 and VCR suppress the expression of PCNA, cyclin D1, cyclin E and Bcl-2, and increase the expression of Bax and casepase-3.
Salvage robot-assisted radical prostatectomy (sRARP) for radiation resistant prostate cancer in a group of initially high risk patients
Authors: Lamichhane Nirmal , Dowrick Adam S. , Axcrona Ulrika , Brennhovd Bjørn , Fosså Sophie D. , Axcrona Karol
Published: September 2019

Introduction: Salvage robot-assisted radical prostatectomy (sRARP) is seen as an attractive option for salvage treatment of radiation therapy -recurrent prostate cancer (PC), thanks in part to the good visualisation that is possible using this modality. However, the results of fewer than 200 salvage sRARPs have been published in the literature. We report the outcomes in a cohort of initially high risk patients of robot-assisted radical prostatectomy as salvage local therapy for radiation-resistant PC in a Scandinavian healthcare setting.

Materials and methods: A retrospective review of the charts of all patients who underwent sRARP for biochemical failure (BCF) after primary radiation treatment for localised PC at a single institution was performed.

Results: Twenty-two patients, median age 67 years (range 57 to 72), had sRARP performed between June 2008 to July 2013. A median follow-up of 26 months (range 2 to 63) was observed. Perioperative complications occurred in 4 patients (18%), with one patient sustaining a rectal injury. Histo-pathological diagnosis was pT2 in three, pT3a in five, pT3b in twelve and pTx in one patient. Ten patients (45%) had a positive surgical margin (PSM). At follow-up, 54 % of patients were free of biochemical progression and 41% were continent.

Conclusions: We showed that salvage RARP is technically feasible in a cohourt of patients with predominantly high risk disease. This study adds to the limited data already in the literature, demonstrating the high frequency of locally advanced (pT3b) PC, a patient group that is usually not included in salvage treatments, as e.g. high frequency ultrasound or salvage brachytherapy. Further, given that the historical barriers to salvage RP with higher rates of rectal injury and poor urinary control no longer seem to be applicable in the modern era, we think that more patients should be considered candidates for this potentially curative salvage treatment of radiation-resistant PC. However, long-term follow-up is needed to confirm if the additional burden on these patients confers to oncological control following the procedure.
Intubating Conditions with three different doses of Rocuronium in surgery of cancer patients
Authors: Wagle Bhawana , Regmi Yogesh
Published: September 2019

Background: This is a prospective randomized, double blind study to determine the doses of rocuronium that would give 90% and 95% probabilities of successful tracheal intubation within 60s after administration. This study evaluated intubating conditions and duration of action of 0.4 mg, 0.8 mg and 1.2 mg of rocuronium, administered intravenously in patients undergoing elective surgical procedures. Goal in this study is to define doses level of rocuronium that would provide optimal relaxation for tracheal intubation in patients in whom succinylcholine was relatively contraindicated.

Methods: Sixty patients both male and female, ASA I & II, age between 18–60 years, with BMI of less that 30 who were planned for elective surgical procedures were randomized into three groups. Group A received 0.4 mg (n=20), Group B received 0.8 mg (n=20) and Group C received 1.2 mg (n=20) of rocuronium. At 60 seconds after injection of the rocuronium, laryngoscopy was initiated, with the goal being endotracheal tube passed through the patient's vocal cords and the cuff inflated within the trachea in 20s. Intubating conditions was graded excellent, good or poor according to Cooper scoring system criteria. When the patient lost consciousness, train-of-four (TOF) stimulation (at 2 Hz and repeated every 12s) were recorded. Immediately after tracheal intubation and every 5 min thereafter the investigator counted the number of tactile TOF responses. The duration of action of rocuronium was defined as the time from the end of injection of rocuronium until reappearance of first tactile response to TOF stimulation.

Results: There were twelve patients in the 0.4mg/kg rocuronium group, two in the 0.8mg/kg group, and one in the 1.2mg/kg rocuronium group with an unacceptable intubation grade caused by sustained coughing at intubation. The D90 and D95 doses were 0.83(0.59 -1.03) and 1.04 (0.76-1.36) mg/kg, respectively. Estimated time until first tactile train-of-four response after D50 and D95 doses were 43min and 52 min, respectively.

Conclusion: After induction with pethedine and sodium thiopentone, rocuronium in a dose of 0.8mg/kg produces equivalent intubating conditions as that of 1.2mg/kg after 60 seconds of administration
Community Screening of Prostate Cancer in Eastern Nepal
Authors: Belbase Narayan , Agrawal C.S.
Published: September 2019

Background: Prostate cancer incurs a substantial incidence and mortality burden, and it ranks among the top ten specific causes of death in males.

Objectives: To explore the situation of prostate cancer in a cohort of healthy population in Eastern Nepal.

Methods: This study was conducted in the Department of General surgery at B. P. Koirala Institute of Health Sciences, Dharan, Nepal in the department of surgery from July 2010 to June 2011. Males above 50 years visiting Surgical Outpatient Department in BPKIHS were enrolled in the study. Screening camps were organized in four Teaching district hospitals of BPKIHS in Eastern Nepal. Digital rectal examination (DRE) was done by the trained professionals after collecting blood for serum prostatic specific antigen (PSA). Trucut biopsy was done for all individuals with abnormal PSA, DRE or both findings.

Results: A total of 1521 males more than 50 years of age were assessed and screened after meeting inclusion criteria. Maximum individuals 1452 (96.2% ) had PSA ≤ 4.0 ng/ml. Abnormal PSA ( > 4 ng/ml) was found in 58 (3.8%) individuals. Abnormal DRE was found in 26 (1.72%) individuals. Both DRE and PSA was abnormal in 26 (1.72%) individuals. On the basis of raised PSA or abnormal DRE 58 (3.84%) individuals were subjected to digitally guided trucut biopsy. Biopsy report revealed Benign Prostatic Hyperplasia in 47 (3.11%) individuals and adenocarcinoma prostate in 11 (0.73%) individuals. The specificity of DRE was 65.95% sensitivity 90.9% and positive predictive value 38.46%. The sensitivity of PSA more than 4ng/ml in detecting carcinoma prostate was 100% and the positive predictive value for serum PSA was 18.96%.

Conclusion: The overall cancer detection rate in this study was 0.73% and those detected were locally advanced. Larger community-based studies are highly warranted specially among high-risk groups.
Melanoma of Urinary Bladder presented as acute urine retention
Authors: Lamichhane Nirmal , Dhakal Hari P.
Published: September 2019

This report is of a 50-year-old man with a rare urinary bladder melanoma. He presented with hematuria followed by bladder outlet obstruction at the time of presentation. Ultrasonogram of the pelvis revealed a mass in the bladder outlet, suggestive of enlarged prostate. Suprapubic cystostomy was then performed. Subsequent transvesical exploration revealed a dark coloured mass at the outlet of bladder, which on histopathology confirmed to be melanoma. After ruling out other possible primary sites, he underwent radical cysto-urethrectomy with urinary diversion. Disease was confirmed with immunohistochemistry. Patient died after 3 months with bilateral lung metastasis.
Anesthetic challenge in removing foreign body mimicking cancer in bronchus from a child
Authors: Wagle Bhawana , Regmi Yogesh
Published: September 2019

We describe a case of 12 years old boy who had recurrent pneumonia for 1 year, under investigation for bronchogenic malignancy. He was found to have foreign body in his bronchus, that was successfully removed with a 11 mm gastroscope.
Video endoscopic inguinal lymphadenectomy and open inguinal lymphadenectomy for penile cancer in China: a systematic review
Authors: Du Jiang-Ping , Lamichhane Nirmal
Published: September 2019

Background: To evaluate the effect between video endoscopic inguinal lymphadenectomy (VEIL) and open inguinal lymphadenectomy (OIL) for penile cancer to provide the evidence-based basis for the selection of the clinical therapy schemes.

Methods: The related clinical controlled trial literatures on the effective comparison of VEIL and OIL were retrieved from the databases of CNKI and Wanfang database. The screening was independently performed by reviewer according to the including and excluding criteria. The related data were extracted and the meta-analysis performed by the RevMan 5.3 software.

Results: A total of 9 trials were included. There were 335 cases of inguinal lymphadenectomies, in which 151 cases were VEIL and 184 cases were OIL. The meta-analysis results showed that there were no statistical differences between the two types of operations in terms of the operative time (WMD=28.74, 95% CI-4.12~61.60, P=0.09), but the difference between VEIL and OIL in term of intra-operative blood loss (WMD=-29.24, 95% CI–55.24~- 22.89, P<0.01), postoperative hospital stays (WMD=-3.43, 95%CI–5.07~-1.80, P<0.01), postoperative drainage time (WMD=-3.81, 95%CI–5.38~-2.23, P<0.01), surgical complications (Number of sides OR=0.53, 95% CI0.34~0.81, P<0.01; Number of cases OR=0.36, 95% CI0.24~0.54, P<0.01).

Conclusion: VEIL has approximately the same time of operation to OIL, but has less intra-operative blood loss, hospital stay, postoperative drainage time and surgical complications.
3D-printed moulds facilitate making an anatomically matched cement spacer for reconstruction long bone defection after resection of tumors of humerous
Authors: Zhao Haltao , Sigdel Arun , Hou Xizhi , Zhang Ting , Zhang Guochuan , Sun Tao
Published: September 2019

Background: A nail and cement spacer is one of the option for the reconstruction of the proximal humerus after tumor resection among prosthesis unaffordable patients. However, making the cement spacer anatomically match its replacement remains challenging.

Presentation of case: A 12-year-old boy was diagnosed with osteosarcoma in the right proximal humerus by core needle biopsy. After preoperative neo-adjuvant chemotherapy, a wide resection was performed, and the defect was reconstructed with an anatomically matched cement spacer. The cement spacer was fabricated using 3D-printed moulds, which were made according to the mirror image of the left humerus based on CT data. The post-operative course was uneventful, and at the 12-month follow-up, the patient is able to move with only some restriction in abduction and upward lift. The MSTD score was 21.

Conclusion: Fabrication of an anatomically matched cement spacer using 3D-printed moulds is a simple, inexpensive, and reproducible procedure for reconstruction complex bone defect.
Bilateral lungs uptake of 99mTc-HDP in a post treated patient with breast carcinoma
Authors: Yadav Ajay Kumar , Ray Raj Narayan , Joshi Swechchha , Ansari Quamrul Haque , Gengbiao YUAN
Published: September 2019

99mTc-HDP radiopharmaceuticals uptake has been reported at various sites and it is known to be induced by various causes. Bilateral lungs uptake of 99mTc-HDP in a post treated patient with breast carcinoma can be a cause of poor renal function as chemotherapy affects renal function. Here we report on a post treated patient with Ca Breast in which rarely having 99mTc-HDP uptake in bilateral lungs. After full cycle of chemotherapy treatment, some patient suffer with poor renal function although it will improve along with time but due to poor renal function there is chance of 99mTc-HDP uptake in lungs during bone Scintigraphy. So Bilateral lungs uptake of 99mTc-HDP in a post treated patient with breast carcinoma on bone scan may suggest rare but due to poor renal function which some time develop after full cycle chemotherapy treatment.
Leukaemia with pregnancy managed at B. P. Koirala Memorial Cancer Hospital
Authors: Pariyar J , Shrestha B , Acharya BC , Sharma KS , Shrestha J , Shrestha S , Sundas S , Panthee S
Published: September 2019

Abstract: Leukaemia during pregnancy is rare, occurring approximately one in every 75,000 to 100,000 pregnancies annually. Chemotherapeutic agents may have harmful effects to the developing baby though leukaemia itself rarely harms the baby. There is no evidence that pregnancy accelerates the progression of disease or affects the outcome. However, treatment dilemmas often occur.

Aims: To study the clinical presentation, treatment and outcome of leukaemia with pregnancy managed at B. P. Koirala Memorial Cancer Hospital (BPKMCH).

Methods: Descriptive study was conducted at BPKMCH. Case records of women with cancer and pregnancy from January 2006 to February 2013 were analyzed regarding their clinical details, treatment, follow-up and feto-maternal outcome.

Results: Six women, of 20 to 28 years had leukaemia with pregnancy among which four were chronic myeloid leukaemia (CML), one was acute lymphocytic leukaemia (ALL) and acute myeloid leukaemia (AML) each. All four cases of CML had conceived while on oral Imatinib; the three case diagnosed in the first trimester opted for immediate termination of pregnancy while the fourth one diagnosed at 22 weeks of pregnancy continued pregnancy and delivered at 34 weeks by emergency caesarean section for severe oligohydramnios. The ALL case diagnosed at 26 weeks of pregnancy wanted termination of pregnancy and immediate induction chemotherapy. The AML case diagnosed at 32 weeks of pregnancy desired to undergo induction chemotherapy with pregnancy but she defaulted treatment and had intrauterine fetal death and died due to postpartum haemorrhage. The baby, delivered to a mother exposed to Imatinib throughout pregnancy, till date has normal growth and development. Five mothers are in remission.

Conclusions: Leukaemia with pregnancy, more common in younger women is rare and posed treatment challenges. Definitive treatment should be individualized according to the desire of the pregnant woman and should include a multi- disciplinary team. Termination of pregnancy in favour of definitive chemotherapy to mother is better and easier during the first trimester of pregnancy. Because of teratogenic effects of chemotherapy, effective contraception be used during therapy to prevent pregnancy.
Biodiesel dari Minyak Goreng Sawit Bekas dengan Katalis Heterogen CaO: Studi Penentuan Rasio Mol Minyak/Metanol dan Waktu Reaksi Optimum
Authors: Haryono Haryono , Rahayu Iman , Yulyati Yati B.
Published: September 2019

Keterbatasan daya dukung bahan bakar fosil terhadap pemenuhan kebutuhan energi yang berkelanjutan dan ramah lingkungan, telah mengarahkan masyarakat pada upaya-upaya untuk menemukan dan mengembangkan sumber-sumber energi alternatif yang bersifat baru dan terbarukan. Salah satunya jenis energi terbarukan tersebut adalah biodiesel. Penelitian ini bertujuan untuk mensintesis biodiesel dengan memanfaatkan limbah minyak goreng sawit bekas. Penelitian dikhususkan pada penentuan rasio mol minyak/metanol dan waktu reaksi transesterifikasi dengan katalis basa heterogen CaO. Rasio mol minyak/metanol dipelajari pada variasi 1/5, 1/10, 1/15, dan 1/20. Sedangkan waktu reaksi divariasikan selama 1, 1,5, 2, 2,5, dan 3 jam. Reaksi dilakukan pada suhu 65oC dan kadar katalis CaO sebanyak 3%. Hasil penelitian menunjukkan bahwa kondisi optimum reaksi dicapai pada saat sintesis biodiesel dilakukan pada rasio mol minyak/metanol sebesar 1/15 dengan lama reaksi 2,5 jam. Pada kondisi reaksi tersebut diperoleh biodiesel dengan beberapa parameter kualitas yang diuji telah sesuai dengan SNI untuk Biodiesel (SNI-04-7182-2006), yaitu: densitas 0,867 g/cm3, viskositas 5,28 mm2/s (pada suhu 40oC), titik kilat 182oC, angka asam 0,28 mg KOH/g, gliserol bebas 0,014%, gliserol total 0,10%, kadar ester 97,8%, dan angka iod 31,62%, serta yield biodiesel sebesar 86,0%.