bluuebunny/crossref_metadata_2025 huggingface dataset:
Parenting among Settled Migrants from Southern Africa: A Qualitative Evidence Synthesis
Authors: Machaka Ruvimbo , Barley Ruth , Serrant Laura , Furness Penny , Dunham Margaret
Published: July 2021

The Global North has over the years been a popular destination for migrants from the Global South. Most of the migrants are in their reproductive ages who go on to bear and raise children. The differences and subjectivity in the context of their experiences may have an impact on how they ensure that their children have the best possible health and well-being. This paper synthesises 14 qualitative research papers, conducted in 6 Global North countries. We gathered evidence on settled Southern African migrants experiences of bearing and raising children in Global North destination countries and how they conceptualise sustaining children’s health and well-being. Results of the review indicated a concerning need for support in sustaining children’s health and well-being. Cultural and religious beliefs underpin how the parents in these studies raise their children. More research is needed which engages with fathers and extended family.
Household Debt, Maternal Well-Being, and Child Adjustment in Germany: Examining the Family Stress Model by Family Structure
Authors: Heintz-Martin Valerie , Recksiedler Claudia , Langmeyer Alexandra N.
Published: July 2021

The amount of household debt tripled globally over the last decades and a sizable share of individuals and families are overindebted due to mortgages, credit cards, or consumer debt. Yet research on the distribution of debt across families, and potential ripple effects of the psychological burden related to debt on well-being and family relations, remains sparse. Our study aims to fill these gaps by examining the socio-demographic profiles of families that have accumulated household debt and the unique role that the psychological burden related to debt plays on associations between mothers’ well-being, parental dynamics, and child adjustment based on the Family Stress Model (FSM). We used representative survey data collected in 2019 from Germany (N = 3271), which is one of the richest economies worldwide, yet about 10% of adults reported to be overindebted. Logistic regression results showed that single mothers were less likely to have debt compared to mothers in two-parent families. However, both single mothers and mothers in stepfamilies with high levels of perceived economic strain were particularly likely to report having debt. Structural equation modeling yielded that the links between the psychological burden of debt, maternal well-being, parental dynamics, and child adjustment were largely in line with the FSM, except for single mothers. We conclude that persisting financial disparities by family structure may be partially fostered by unique characteristics of the German welfare state, such as promoting more a traditional two-parent norm, and discuss our findings in light of practical implications.
Interactions of BRCA1-mutated Breast Cancer Cell Lines with Adipose-derived Stromal Cells (ADSCs)
Authors: Plangger Adelina , Haslik Werner , Rath Barbara , Neumayer Christoph , Hamilton Gerhard
Published: July 2021

Lipofilling may constitute a technique to assist reconstruction of breasts following prophylactic mastectomy for patients with mutated BRCA1 or BRCA2 genes. However, to date it is not clear whether adipose-derived stromal cells (ADSCs) increase the risk of tumor initiation and progression in this situation. Therefore, the interactions of BRCA1 mutated breast cancer cell lines with normal ADSCs were investigated in the present study. Characteristics of MDA-MB-436 (BRCA1 c.5277 + 1G > A) and HCC1937 (BRCA1 p.Gln1756.Profs*74) were compared to MDA-MB-231 and T47D BRCA1/2 wild-type breast cancer cell lines. ADSCs were cultivated from lipoaspirates of a panel of BRCA1/2- wildtype patients. Interactions of conditioned medium (CM) of these cells with the breast cancer lines were studied using proliferation and migration assays as well as adipokine expression western blot arrays. CM of ADSCs exhibit a dose-dependent stimulation of the proliferation of the breast cancer cell lines. However, of the ADSC preparations tested, only 1 out of 18 samples showed a significant higher stimulation of BRCA1-mutated MDA-MB-436 versus wildtype MDA-MB-231 cells, and all CM revealed lower stimulatory activity for BRCA1-mutated HCC1937 versus wildtype T47D cells. Additionally, migration of breast cancer cells in response to CM of ADSCs proved to be equivalent or slower for BRCA1/2 mutated versus nonmutated cancer cells and, with exception of angiopoietin-like 2, induced expression of adipokines showed no major difference. Effects of media conditioned by normal ADSCs showed largely comparable effects on BRCA1-mutated and wildtype breast cancer cell lines thus advocating lipofilling, preferentially employing allogeneic non-mutated ADSCs.
Nonlinear reduced-order model for vertical sloshing by employing neural networks
Authors: Pizzoli Marco , Saltari Francesco , Mastroddi Franco , Martinez-Carrascal Jon , González-Gutiérrez Leo M.
Published: July 2021

The aim of this work is to provide a reduced-order model to describe the dissipative behavior of nonlinear vertical sloshing involving Rayleigh–Taylor instability by means of a feed forward neural network. A 1-degree-of-freedom system is taken into account as representative of fluid–structure interaction problem. Sloshing has been replaced by an equivalent mechanical model, namely a boxed-in bouncing ball with parameters suitably tuned with performed experiments. A large data set, consisting of a long simulation of the bouncing ball model with pseudo-periodic motion of the boundary condition spanning different values of oscillation amplitude and frequency, is used to train the neural network. The obtained neural network model has been included in a Simulink®  environment for closed-loop fluid–structure interaction simulations showing promising performances for perspective integration in complex structural system.
Pituitary society expert Delphi consensus: operative workflow in endoscopic transsphenoidal pituitary adenoma resection
Authors: Marcus Hani J. , Khan Danyal Z. , Borg Anouk , Buchfelder Michael , Cetas Justin S. , Collins Justin W. , Dorward Neil L. , Fleseriu Maria , Gurnell Mark , Javadpour Mohsen , Jones Pamela S. , Koh Chan Hee , Layard Horsfall Hugo , Mamelak Adam N. , Mortini Pietro , Muirhead William , Oyesiku Nelson M. , Schwartz Theodore H. , Sinha Saurabh , Stoyanov Danail , Syro Luis V. , Tsermoulas Georgios , Williams Adam , Winder Mark J. , Zada Gabriel , Laws Edward R.
Published: July 2021

Purpose

Surgical workflow analysis seeks to systematically break down operations into hierarchal components. It facilitates education, training, and understanding of surgical variations. There are known educational demands and variations in surgical practice in endoscopic transsphenoidal approaches to pituitary adenomas. Through an iterative consensus process, we generated a surgical workflow reflective of contemporary surgical practice.

Methods

A mixed-methods consensus process composed of a literature review and iterative Delphi surveys was carried out within the Pituitary Society. Each round of the survey was repeated until data saturation and > 90% consensus was reached.

Results

There was a 100% response rate and no attrition across both Delphi rounds. Eighteen international expert panel members participated. An extensive workflow of 4 phases (nasal, sphenoid, sellar and closure) and 40 steps, with associated technical errors and adverse events, were agreed upon by 100% of panel members across rounds. Both core and case-specific or surgeon-specific variations in operative steps were captured.

Conclusions

Through an international expert panel consensus, a workflow for the performance of endoscopic transsphenoidal pituitary adenoma resection has been generated. This workflow captures a wide range of contemporary operative practice. The agreed “core” steps will serve as a foundation for education, training, assessment and technological development (e.g. models and simulators). The “optional” steps highlight areas of heterogeneity of practice that will benefit from further research (e.g. methods of skull base repair). Further adjustments could be made to increase applicability around the world.
The Ethics of Automated Vehicles: Why Self-driving Cars Should not Swerve in Dilemma Cases
Authors: Lawlor Rob
Published: July 2021

In this paper, I will argue that automated vehicles should not swerve to avoid a person or vehicle in its path, unless they can do so without imposing risks onto others. I will argue that this is the conclusion that we should reach even if we start by assuming that we should divert the trolley in the standard trolley case (in which the trolley will hit and kill five people on the track, unless it is diverted onto a different track, where it will hit and kill just one person). In defence of this claim, I appeal to the distribution of moral and legal responsibilities, highlighting the importance of safe spaces, and arguing in favour of constraints on what can be done to minimise casualties. My arguments draw on the methodology associated with the trolley problem. As such, this paper also defends this methodology, highlighting a number of ways in which authors misunderstand and misrepresent the trolley problem. For example, the ‘trolley problem’ is not the ‘name given by philosophers to classic examples of unavoidable crash scenarios, historically involving runaway trolleys’, as Millar suggests, and trolley cases should not be compared with ‘model building in the (social) sciences’, as Gogoll and Müller suggest. Trolley cases have more in common with lab experiments than model building, and the problem referred to in the trolley problem is not the problem of deciding what to do in any one case. Rather, it refers to the problem of explaining what appear to be conflicting intuitions when we consider two cases together. The problem, for example, could be: how do we justify the claim that automated vehicles should not swerve even if we accept the claim that we should divert the trolley in an apparently similar trolley case?
Small firms and the COVID-19 insolvency gap
Authors: Dörr Julian Oliver , Licht Georg , Murmann Simona
Published: July 2021

COVID-19 placed a special role on fiscal policy in rescuing companies short of liquidity from insolvency. In the first months of the crisis, SMEs as the backbone of Germany’s economy benefited from large and mainly indiscriminate aid measures. Avoiding business failures in a whatever-it-takes fashion contrasts, however, with the cleansing mechanism of economic crises: a mechanism which forces unviable firms out of the market, thereby reallocating resources efficiently. By focusing on firms’ pre-crisis financial standing, we estimate the extent to which the policy response induced an insolvency gap and analyze whether the gap is characterized by firms which were already struggling before the pandemic. With the policy measures being focused on smaller firms, we also examine whether this insolvency gap differs with respect to firm size. Our results show that the COVID-19 policy response in Germany has triggered a backlog of insolvencies that is particularly pronounced among financially weak, small firms, having potential long-term implications on entrepreneurship and economic recovery.

Plain English Summary This study analyzes the extent to which the strong policy support to companies in the early phase of the COVID-19 crisis has prevented a large wave of corporate insolvencies. Using data of about 1.5 million German companies, it is shown that it was mainly smaller firms that experienced strong financial distress and would have gone bankrupt without policy assistance. In times of crises, insolvencies usually allow for a reallocation of employees and capital to more efficient firms. However, the analysis reveals that this ‘cleansing effect’ is hampered in the current crisis as the largely indiscriminate granting of liquidity subsidies and the temporary suspension of the duty to file for insolvency have caused an insolvency gap that is driven by firms which were already in a weak financial position before the crisis. Overall, the insolvency gap is estimated to affect around 25,000 companies, a substantial number compared to the around 16,300 actual insolvencies in 2020. In the ongoing crisis, policy makers should prefer instruments favoring entrepreneurs who respond innovatively to the pandemic instead of prolonging the survival of near-insolvent firms.
Solidarity of the shaken: from the experience (Erlebnis) to history
Authors: Belejkaničová Michaela
Published: July 2021

In his Heretical Essays, Jan Patočka introduces the concept of the solidarity of the shaken. He argues that it emerges in the conditions of political violence—the frontline experience (Fronterlebnis). Moreover, Patočka brings into discussion the puzzling concepts of day, night, metanoia and sacrifice, which only further problematise the idea. Researching how other thinkers have examined the phenomenon of the frontline experience, it becomes obvious that Patočka did not invent the obscure vocabulary ex nihilo. Concepts such as frontline experience, sacrifice and the metaphors of the day and night were commonly used by thinkers in the inter-war and post-war eras in their examination of community (Gemeinschaft). This study aims to reconstruct the idea of the solidarity of the shaken as contextualized within a broader scholarly debate on the concept of community (Gemeinschaft). Through the critical dialogue between Patočka’s works and the works of Ernst Jünger and Pierre Teilhard de Chardin, this study will portray how Patočka, in his discourse on the frontline experience, follows the usual pattern of overcoming one’s individuality, transcending and opening up to the constitution of solidarity. This paper will argue that Patočka defined the solidarity of the shaken in an attempt to revive the positive aspects of a community and break with the regressive (if not sinister) uses to which it was put in the twentieth century.
Models, structures, and the explanatory role of mathematics in empirical science
Authors: Leng Mary
Published: July 2021

Are there genuine mathematical explanations of physical phenomena, and if so, how can mathematical theories, which are typically thought to concern abstract mathematical objects, explain contingent empirical matters? The answer, I argue, is in seeing an important range of mathematical explanations asstructural explanations, where structural explanations explain a phenomenon by showing it to have been an inevitable consequence of the structural features instantiated in the physical system under consideration. Such explanations are best cast as deductive arguments which, by virtue of their form, establish that,giventhe mathematical structure instantiated in the physical system under consideration, the explanandumhadto occur. Against the claims of platonists such as Alan Baker and Mark Colyvan, I argue that formulating mathematical explanations as structural explanations in this way shows that we can accept that mathematics can play an indispensable explanatory role in empirical science without committing to the existence of any abstract mathematical objects.
Removing politics from innovations that improve food security
Authors: Smyth Stuart J. , McHughen Alan , Entine Jon , Kershen Drew , Ramage Carl , Parrott Wayne
Published: July 2021

Genetically modified (GM) organisms and crops have been a feature of food production for over 30 years. Despite extensive science-based risk assessment, the public and many politicians remain concerned with the genetic manipulation of crops, particularly food crops. Many governments have addressed public concern through biosafety legislation and regulatory frameworks that identify and regulate risks to ensure human health and environmental safety. These domestic regulatory frameworks align to international scientific risk assessment methodologies on a case-by-case basis. Regulatory agencies in 70 countries around the world have conducted in excess of 4400 risk assessments, all reaching the same conclusion: GM crops and foods that have been assessed provide no greater risk to human health or the environment than non-GM crops and foods. Yet, while the science regarding the safety of GM crops and food appears conclusive and societal benefits have been globally demonstrated, the use of innovative products have only contributed minimal improvements to global food security. Regrettably, politically-motivated regulatory barriers are currently being implemented with the next genomic innovation, genome editing, the implications of which are also discussed in this article. A decade of reduced global food insecurity was witnessed from 2005 to 2015, but regrettably, the figure has subsequently risen. Why is this the case? Reasons have been attributed to climate variability, biotic and abiotic stresses, lack of access to innovative technologies and political interference in decision making processes. This commentary highlights how political interference in the regulatory approval process of GM crops is adversely affecting the adoption of innovative, yield enhancing crop varieties, thereby limiting food security opportunities in food insecure economies.
Low endogenous testosterone levels are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection
Authors: Porcaro Antonio Benito , Cerrato Clara , Tafuri Alessandro , Bianchi Alberto , Gallina Sebastian , Orlando Rossella , Amigoni Nelia , Rizzetto Riccardo , Gozzo Alessandra , Migliorini Filippo , Zecchini Antoniolli Stefano , Monaco Carmelo , Brunelli Matteo , Cerruto Maria Angela , Antonelli Alessandro
Published: July 2021

Objective

To investigate clinical factors associated to lymphnodal metastasis load in patients who underwent to radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND).

Materials and methods

Between November 2014 and December 2019, ET was measured in 617 consecutive patients not under androgen deprivation therapy who underwent RP and ePLND. Lymphnode invasion (LNI) was codified as not present (N = 0) or with one (N = 1) or more than one metastatic node (N > 1). The risk of multiple pelvic lymph node metastasis (N > 1, mPLNM) was assessed by comparing it to the other two groups (N > 1 vs. N = 0 and N > 1 vs. N = 1). Then, we assessed the association between ET and lymphnode invasion for standard predictors, such as PSA, percentage of biopsy positive cores (BPC), tumor stage greater than 1 (cT > 1) and tumor grade group greater than two (ISUP > 2).

Results

Overall, LNI was detected in 70 patients (11.3%) of whom 39 (6.3%) with N = 1 and 31 (5%) with N > 1. On multivariate analysis, ET was inversely associated with the risk of N > 1 when compared to both N = 0 (odds ratio, OR 0.997; CI 0.994–1; p = 0.027) as well as with N = 1 cases (OR 0.994; 95% CI 0.989–1.000; p = 0.015).

Conclusions

In clinical PCa, the risk of mPLNM was increased by low ET levels. As ET decreased, patients had an increased likelihood of mPLNM. Because of the inverse association between ET and mPLNM, higher ET levels were protective against aggressive disease. The influence of locally advanced PCa with high metastatic load on ET levels needs to be explored by controlled trials.
Sedimentology and sediment geochemistry of the pelagic Paryab section (Zagros Mountains, Iran): implications for sea level fluctuations and paleoenvironments in the late Paleocene to middle Eocene
Authors: Azami Seyed Hamidreza , Wagreich Michael , Mehrizi Maryam Mortazavi , Gharaie Mohamad Hosein Mahmudy , Gier Susanne , Leckie R. Mark
Published: July 2021

Sedimentological and geochemical records are presented for an upper Paleocene to middle Eocene deep-water pelagic succession of the Pabdeh Formation in the Paryab section, Zagros Mountains, NW, Iran. In this study, grain-size statistical parameters, cumulative curves, and bivariate analysis on twenty-five sediment samples were used to decipher depositional processes and paleoenvironments. XRD analysis of the fine-grained silt to clay sediments indicates that quartz, calcite, ankerite/dolomite, and clay minerals such as illite, chlorite, and kaolinite constitute the main minerals within these sediments. Elemental and isotopic chemostratigraphies are used to infer depositional conditions and sea level trends through time. TOC-CaCO3 trends of the samples are used to interpret the type of deposition and sediment accumulation rates, rhythmic bedding, and identification of regressional and transgressional phases. In the studied section, the manganese contents exhibit a declining trend along the lowstand systems tract that terminates in a sea level lowstand and the subsequent start of a transgressive trend. Some geochemical parameters such as Mn values and δ13C contents of sediments along a sequence can be used as potential sea level proxies that are tested in this study. The Paleocene-Eocene Thermal Maximum (PETM) interval of the Pabdeh Formation coincides with increasing Mn contents and Mn/Al ratios. Ti/Al and Si/Al ratios show contrasting trends to Mn values and Mn/Al ratios. Generally, elemental and isotopic results of the Pabdeh Formation confirm the presence of a long-term three-stage sea level cycle in the studied interval that is related to the PETM event. Based on elemental analyses such as Co, Mo, Ni, V, and Cr contents, the Pabdeh Formation sediments were deposited in suboxic to slightly anoxic conditions.
Trait profile of maize varieties preferred by farmers and value chain actors in northern Ghana
Authors: Adu Gloria Boakyewaa , Badu-Apraku Baffour , Akromah Richard , Amegbor Isaac Kodzo , Adogoba Desmond Sunday , Haruna Alidu , Manigben Kulai Amadu , Aboyadana Paulina Abanpoka , Wiredu Alexander Nimo
Published: July 2021

Plant breeders’ knowledge of precise traits preferred by variety users would accelerate varietal turnover and widen adoption of newly developed maize varieties in Ghana. The objective of this research was to provide empirical evidence of trait preferences of farmers and other actors in the maize value chain in northern Ghana, based on which research strategies for maize improvement could be formulated. Participatory rural appraisal was conducted in 2016 to determine key traits preferred by maize value chain actors across the three regions in northern Ghana. A total of 279 maize value chain actors were interviewed. Different scoring and ranking techniques were used to assess the maize traits preferred by the different actors. Participatory variety selection trials were also conducted in the Tolon, West Gonja, Binduri, and Sissala East districts in northern Ghana from 2014 to 2016. The mother-baby trial approach was used to evaluate eight hybrids with 3000 farmers. Data on yield and agronomic performance of the hybrids and farmer’s selection criteria were collected. Data analyses were performed using GenStat Edition 16 and SPSS Edition 20 statistical packages. The participatory rural appraisal method identified farmers, input dealers, traders, and processors as the primary maize value chain actors in the study areas. Trait preferences of the different actors overlapped and revolved around grain quality including nutritional value, and stress tolerance and grain yield. Results of the participatory variety selection study revealed that across districts, farmers preferred high-yielding varieties with multiple cobs per plant, white grain endosperm color, and bigger and fully filled cobs. For the first time, our holistic assessment of the trait preferences of key actors of the maize value chain in northern Ghana revealed a comprehensive list of traits, which could be used by breeders to develop varieties that may be preferred by all value chain actors in northern Ghana.
Equal Protection by Race with Stop and Frisk: a Risk-Adjusted Disparity (RAD) Index for Balanced Policing
Authors: Sherman Lawrence W. , Kumar Sumit
Published: July 2021

Research Question

Can racial equity in crime and policing be measured with the use of a Risk-Adjusted Disparity (RAD) Index of the degree to which policing across racial categories is “balanced” in its ratios of preventive police actions per 100 serious crimes committed against members of each racial category?

Data

Office of National Statistics (ONS) reports on crime and policing in England and Wales, and Dorset Police data on violent crime victimization and stop-search by race of suspect across the 452 Lower-Layer Super-Output Levels in Dorset.

Methods

We conceptualize the problem of equal protection under law as fundamentally protecting the lives and liberties of each citizen from criminal harms, as well as from disproportionately intrusive policing. We combine these dimensions into a single metric that defines proportionality of policing in relation to risk of violent crime victimization, such that whatever intrusion on liberty is applied for the aim of protection can be equalized across racial groups.

Findings

The use of a Risk-Adjusted Disparity (RAD) Index to measure reliably the equality of police intrusions across racial groups based on victimization rates can be illustrated by adjusting for homicide. In the past decade, the population-based disparity rate shows that Blacks are stopped by police nine times more often than whites. When that rate is adjusted for the differential risk of homicide in the two groups, the disparity estimate drops from 800% to 58%. Other changes of major magnitude result from using the RAD Index.

Conclusions

We conclude that an index of proactive policing using victimizations by race is more likely to lead to equal protection of law than a residential population-based metric of proactive police actions, as is commonly used in official reporting. A victim-based, Risk-Adjusted (RAD) Index for measuring racial disparity might focus police efforts on the 5% of local areas where serious violence is concentrated, and deflect stops away from the vast majority of areas that have little serious crime.
Parametric oscillation and amplification with gate controlled capacitor-within-capacitor
Authors: Grebel H.
Published: July 2021

Parametric oscillators and parametric amplifiers are known for their ‘quiet’ operation and find new applications in quantum circuitry. A Capacitor-within-Capacitor (CWC) is a nested electronic element that has two components: the cell (e.g., the outer capacitor) and the gate (e.g., the inner capacitor). Here we provide analysis and experiments on diode-interfaced, CWC that exhibit parametric oscillations and parametric amplifications. By replacing the diode with a doped nano-graphene junction, we demonstrated a new structure whose doping may be electronically and chemically controlled. Advantages of these elements are in their simplicity, large relative capacitance change (of the order of 50%), separation of pump and signal channels and possibility for large integration.
Comparison between SARIMA and Holt–Winters models for forecasting monthly streamflow in the western region of Cuba
Authors: Alonso Brito Gustavo Reinel , Rivero Villaverde Anaily , Lau Quan Andrés , Ruíz Pérez María Elena
Published: July 2021

The present study aims to compare SARIMA and Holt–Winters model forecasts of mean monthly flow at the V Aniversario basin, western Cuba. Model selection and model assessment are carried out with a rolling cross-validation scheme using mean monthly flow observations from the period 1971–1990. Model performance is analyzed in one- and two-year forecast lead times, and comparisons are made based on mean squared error, root mean squared error, mean absolute error and the Nash–Sutcliffe efficiency; all these statistics are computed from observed and simulated time series at the outlet of the basin. The major findings show that Holt–Winters models had better performance in reproducing the mean series seasonality when the training observations were insufficient, while for longer training subsets, both models were equally competitive in forecasting one year ahead. SARIMA models were found to be more reliable for longer lead-time forecasts, and their limitations after being trained on short observation periods are due to overfitting problems.

Article Highlights

Comparison based on rolling cross-validation revealed the models forecasts sensibility to available observations amount.

HW and SARIMA models perform better when limited observations or long-view forecasting, respectively, otherwise they do similar.

HW models were superior modeling less variable monthly flows while SARIMA models better forecast the highly variable periods.
Advances in Genetic Diagnosis of Kallmann Syndrome and Genetic Interruption
Authors: Liu Yujun , Zhi Xu
Published: July 2021

Kallmann syndrome (KS) is a rare hereditary disease with high phenotypic and genetic heterogeneity. Congenital hypogonadotropic hypogonadism and hyposmia/anosmia are the two major characterized phenotypes of KS. Besides, mirror movements, dental agenesis, digital bone abnormalities, unilateral renal agenesis, midline facial defects, hearing loss, and eye movement abnormalities can also be observed in KS patients. Because of the phenotypic heterogeneity, genetic diagnosis become increasingly valuable to distinguish KS from other disorders including normosmic congenital hypogonadotropic hypogonadism, constitutional delay of growth and puberty, CHARGE syndrome, and functional hypogonadotropic hypogonadism. Application of next-generation sequencing has promoted the discovery of novel pathogenic genes in KS pedigrees. Prenatal diagnosis is an effective method in clinical settings to decrease birth defects and block transmission of genetic disorders. However, pregnant women may suffer from physical and psychological distress when fetuses are diagnosed with congenital defects. Preimplantation genetic testing (PGT) is a prospective approach during the in vitro fertilization process that helps to interrupt transmission of hereditary diseases to offspring at an early stage. Thus, genetic testing and counseling are recommended to KS patients with family histories, prenatal diagnosis and PGT are considered to be useful options.
Cytogenetic Influence on Prognosis in Acute Promyelocytic Leukaemia
Authors: Vu Minh Phuong , Nguyen Cuc Nhung , Vu Hoang
Published: July 2021

Objective/Background:

To analyse the influence of chromosomal aberrations in addition to t(15;17)(q22;q21) in acute promyelocytic leukaemia (APL) on clinical characteristics and treatment outcomes.

Methods:

Fifty-seven patients with new APL diagnoses underwent conventional cytogenetic analysis; fluorescence in situ hybridization for t(15;17)(q22;q21) and reverse transcriptase–polymerase chain reaction detected PML/RARα in two forms: L (length) and S (short) and accepted treatment with all-trans retinoic acid and chemotherapy. Patients with additional chromosome aberrations were designated as the complex karyotype group and were compared with patients with only t(15;17), who were designated as the simple karyotype group.

Results:

Additional chromosome aberrations was observed in 18/57 patients (31.6%) at initial diagnosis. Outcome was significantly different between the simple karyotype group and the complex karyotype group for complete remission (92.3% vs. 66.7% respectively, p = .025), overall survival at 3 years (92.3% vs. 65.0%, respectively, p = .017), and progression-free survival at 3 years (81.4% vs. 44.4%, respectively, p = .024).

Conclusions:

Additional chromosome aberrations had adverse effects on the prognosis in APL.
Duhem and Holism
Authors: Ivanova Milena
Published: July 2021

The holistic thesis developed by Pierre Duhem challenges the idea that our evidence can conclusively falsify a theory. Given that no scientific theory is tested in isolation, a negative experiment can always be attributed to components other than the theory we test – to the auxiliary hypotheses and background assumptions. How do scientists decide whether the experimental result undermines the theory or points at an error in the underlying assumptions? Duhem argues that we cannot offer a rule that directs when the scientist should employ a radical or conservative strategy in light of a negative result, and ultimately they will appeal to their intuition. More recently philosophers have offered a number of strategies of how to locate error and justify the abandonment of a theory or an auxiliary hypothesis. This Element analyses Duhem's response to holism and subsequent accounts of how the problem can be resolved.
Narrative coherence inDigenes Akrites(G)
Authors: Kulhánková Markéta
Published: July 2021

This article argues that coherence in medieval narratives was perceived differently than it is in modern literature, offering an analysis of coherence principles inDigenes Akriteswhich seem to have been more relevant for its original audiences. Drawing on contemporary narratology and recent research on comparable western works, the author does not search for one sole superordinate principle, but rather for so-called structures of mid-range coherence. The article contains some examples of such ‘centres of gravity’ – the schema, the scene and the meaning – in the G version.
The EU Digital COVID Certificate: A Preliminary Data Protection Impact Assessment
Authors: GSTREIN Oskar Josef
Published: July 2021

On 20 May 2021, the European Commission, Council and Parliament announced a breakthrough in the trialogue negotiations to establish the European Union (EU) Digital COVID Certificate. Originally, this standardisation effort was labelled as “Digital Green Certificate” and – “[i]n view of the urgency” – presented without a data protection impact assessment. It should allow citizens and residents of Member States to prove that they are either vaccinated against COVID-19, have recently tested negative or are currently immune against the virus. This article considers the proposal from a privacy perspective, taking into account the opinion of EU data protection authorities, ongoing negotiations in the EU institutions and relevant developments on the national and international level. While the European Parliament and others tried to improve the original Commission proposal, questions around the appropriateness and effectiveness of the framework remain. The technological and organisational implementation is essentially left to Member States, who already have started to develop their own tracing and identification systems.
Spatiotemporal supraglacial pond and ice cliff changes in the Bhutan–Tibet border region from 2016 to 2018
Authors: Taylor Caroline Jane , Carr Joanne Rachel , Rounce David Robert
Published: July 2021

Supraglacial ponds and ice cliffs can dramatically enhance ablation rates on debris-covered glaciers. Supraglacial ponds can also coalesce, forming moraine-dammed lakes at risk of glacial lake outburst flood (GLOF). Given Bhutanese glaciers have some of the highest ice loss rates in the Himalaya and GLOF vulnerability is high, we seek to advance our understanding of the spatial distribution and evolution of supraglacial ponds and ice cliffs. Here, we use high-resolution (3 m) Planet Labs satellite imagery to provide the first short-term, high-resolution dataset of supraglacial pond and ice cliff evolution for three glaciers along the Bhutan–Tibet border from 2016 to 2018. A total of 5754 ponds and 2088 ice cliffs were identified. Large intra-annual changes were observed, with ponded area changes and drainage events coinciding with the seasonality of the Indian Summer Monsoon. On average, ~19% of the total number of ponds had a coincident ice cliff. Pond spatial distribution was driven by ice-surface velocities, with higher numbers of ponds found in areas of low velocity (<8 m a−1). Our study provides the first detailed, quantitative investigation of supraglacial ponds and ice cliffs in Bhutan, providing a framework for further monitoring in this understudied, yet important, region of the Himalaya.
Militarization and Perceptions of Law Enforcement in the Developing World: Evidence from a Conjoint Experiment in Mexico
Authors: Flores-Macías Gustavo , Zarkin Jessica
Published: July 2021

Although a growing body of research suggests that the constabularization of the military for domestic policing is counterproductive, this increasingly prevalent policy has nonetheless enjoyed widespread support in the developing world. This study advances our understanding of the consequences of militarization for perceptions of law enforcement: whether visual features shape perceptions of effectiveness, respect for civil liberties, proclivity for corruption and acceptance of militarization in one's own neighborhood. Based on a nationally representative, image-based, conjoint experiment conducted in Mexico, the authors find that military weapons and uniforms enhance perceptions of effectiveness and respect for civil liberties, and that the effect of military uniform becomes greater with increased military presence. The study also finds that gender shapes perceptions of civil liberties and corruption, but detects no effect for skin color. The findings suggest that a central feature of militarization linked to greater violence – military weapons – is paradoxically a key factor explaining favorable attitudes, and that women can play a crucial role in improving perceptions of law enforcement.
QUANTITATIVE ESTIMATE FOR THE MEASURE OF A SET OF REAL NUMBERS
Authors: BUDARINA NATALIA
Published: July 2021

Abstarct

An effective estimate for the measure of the set of real numbers for which the inequality |P(x)| {3 \over 2}n + 1$ has a solution in integral polynomials P of degree n and of height H(P) at most $Q \in {\rm{\mathbb N}}$ is obtained.
Social Positioning and International Order Contestation in Early Modern Southeast Asia
Authors: Chia Colin
Published: July 2021

Identities and ideas can lead to international order contestation through the efforts of international actors to socially position themselves and perform their identities. International actors try to shape the world to suit who they want to be. To substantiate this argument, I examine the contestation of international orders in early modern Southeast Asia. The prevailing view portrays a Confucian international order which formed a consensual and stable hierarchy in East Asia. However, instead of acquiescing to hegemonic leadership, both Siam and Vietnam frequently sought to assert their equality and even superiority to the Chinese dynasties. I argue that both polities engaged in political contention to define their places in relation to other polities and the broader social context in which they interacted. I examine how international order contestation emerged from efforts to define and redefine background knowledge about social positioning, social categorization, and the political ontologies and beliefs about collective purpose on which they are based. I claim that agents seek to interact with others in ways that reify their sense of self, and challenge the background knowledge embedded in performances of other actors that threaten their ability to perform their identity. I also argue against theories that attribute international order contestation to hegemonic decline or the breakdown of a tacit bargain, which assume that orders are held together by a dominant power. One implication is that hegemony and hierarchy are based on dominant ideas, not dominant states.
Ban Chiang, Northeast Thailand, Volume 2: Metals
Authors: Welch David J.
Published: July 2021

These three volumes, along with the forthcoming Volume 2D, the catalogue of metal and metal-related finds, present the results of a thorough, detailed study of the metals recovered during archaeological investigations in 1974 and 1975 at the village of Ban Chiang and three smaller sites in the northern part of northeast Thailand. At a time when little was known of Southeast Asian prehistory, the finding of very elaborately painted earthenware pottery vessels, probably prehistoric, at Ban Chiang stirred the interest not only of archaeologists, but also, unfortunately, from the standpoint of scientific investigation of the past, that of looters, dealers, and collectors of antiquarian art. In order to recover a sample of these vessels in their original depositional context, the Thailand Fine Arts Department and the University of Pennsylvania undertook one of the largest excavations of a prehistoric site carried out in Southeast Asia at the time. What subsequently caused added excitement in the media and the scientific community was the recovery of artefacts of iron that appeared to date to the second millennium BCE and of copper or bronze associated with dates in the fourth millennium BCE, perhaps as early as 3600 BCE, seeming to confirm similar early dates for bronze working from the nearby site of Non Nok Tha. Such early dates suggested the possibility of an independent development of metallurgy in Southeast Asia. Because of the importance of the excavation at Ban Chiang as a milestone in Thai and Southeast Asian archaeology, the site was later placed on the UNESCO World Heritage List.
Transcranial direct current stimulation (tDCS) combined with cognitive training in adolescent boys with ADHD: a double-blind, randomised, sham-controlled trial
Authors: Westwood Samuel J. , Criaud Marion , Lam Sheut-Ling , Lukito Steve , Wallace-Hanlon Sophie , Kowalczyk Olivia S. , Kostara Afroditi , Mathew Joseph , Agbedjro Deborah , Wexler Bruce E. , Cohen Kadosh Roi , Asherson Philip , Rubia Katya
Published: July 2021

Background

Transcranial direct current stimulation (tDCS) could be a side-effect-free alternative to psychostimulants in attention-deficit/hyperactivity disorder (ADHD). Although there is limited evidence for clinical and cognitive effects, most studies were small, single-session and stimulated left dorsolateral prefrontal cortex (dlPFC). No sham-controlled study has stimulated the right inferior frontal cortex (rIFC), which is the most consistently under-functioning region in ADHD, with multiple anodal-tDCS sessions combined with cognitive training (CT) to enhance effects. Thus, we investigated the clinical and cognitive effects of multi-session anodal-tDCS over rIFC combined with CT in double-blind, randomised, sham-controlled trial (RCT, ISRCTN48265228).

Methods

Fifty boys with ADHD (10–18 years) received 15 weekday sessions of anodal- or sham-tDCS over rIFC combined with CT (20 min, 1 mA). ANCOVA, adjusting for baseline measures, age and medication status, tested group differences in clinical and ADHD-relevant executive functions at posttreatment and after 6 months.

Results

ADHD-Rating Scale, Conners ADHD Index and adverse effects were significantly lower at post-treatment after sham relative to anodal tDCS. No other effects were significant.

Conclusions

This rigorous and largest RCT of tDCS in adolescent boys with ADHD found no evidence of improved ADHD symptoms or cognitive performance following multi-session anodal tDCS over rIFC combined with CT. These findings extend limited meta-analytic evidence of cognitive and clinical effects in ADHD after 1–5 tDCS sessions over mainly left dlPFC. Given that tDCS is commercially and clinically available, the findings are important as they suggest that rIFC stimulation may not be indicated as a neurotherapy for cognitive or clinical remediation for ADHD.
The non-specific nature of mental health and structural brain outcomes following childhood trauma
Authors: Haidl Theresa K. , Hedderich Dennis M. , Rosen Marlene , Kaiser Nathalie , Seves Mauro , Lichtenstein Thorsten , Penzel Nora , Wenzel Julian , Kambeitz-Ilankovic Lana , Ruef Anne , Popovic David , Schultze-Lutter Frauke , Chisholm Katharine , Upthegrove Rachel , Salokangas Raimo K. R. , Pantelis Christos , Meisenzahl Eva , Wood Stephen J. , Brambilla Paolo , Borgwardt Stefan , Ruhrmann Stephan , Kambeitz Joseph , Koutsouleris Nikolaos
Published: July 2021

Background

Childhood trauma (CT) is associated with an increased risk of mental health disorders; however, it is unknown whether this represents a diagnosis-specific risk factor for specific psychopathology mediated by structural brain changes. Our aim was to explore whether (i) a predictive CT pattern for transdiagnostic psychopathology exists, and whether (ii) CT can differentiate between distinct diagnosis-dependent psychopathology. Furthermore, we aimed to identify the association between CT, psychopathology and brain structure.

Methods

We used multivariate pattern analysis in data from 643 participants of the Personalised Prognostic Tools for Early Psychosis Management study (PRONIA), including healthy controls (HC), recent onset psychosis (ROP), recent onset depression (ROD), and patients clinically at high-risk for psychosis (CHR). Participants completed structured interviews and self-report measures including the Childhood Trauma Questionnaire, SCID diagnostic interview, BDI-II, PANSS, Schizophrenia Proneness Instrument, Structured Interview for Prodromal Symptoms and structural MRI, analyzed by voxel-based morphometry.

Results

(i) Patients and HC could be distinguished by their CT pattern with a reasonable precision [balanced accuracy of 71.2% (sensitivity = 72.1%, specificity = 70.4%, p ≤ 0.001]. (ii) Subdomains ‘emotional neglect’ and ‘emotional abuse’ were most predictive for CHR and ROP, while in ROD ‘physical abuse’ and ‘sexual abuse’ were most important. The CT pattern was significantly associated with the severity of depressive symptoms in ROD, ROP, and CHR, as well as with the PANSS total and negative domain scores in the CHR patients. No associations between group-separating CT patterns and brain structure were found.

Conclusions

These results indicate that CT poses a transdiagnostic risk factor for mental health disorders, possibly related to depressive symptoms. While differences in the quality of CT exposure exist, diagnostic differentiation was not possible suggesting a multi-factorial pathogenesis.
Investigating the Mechanisms Driving Referent Selection and Retention in Toddlers at Typical and Elevated Likelihood for Autism Spectrum Disorder
Authors: GLIGA Teodora , SKOLNICK Alex , LIERSCH Ute , CHARMAN Tony , JOHNSON Mark H , BEDFORD Rachael ,   The BASIS Team
Published: July 2021

It was suggested that children's referent selection may not lay memory traces sufficiently strong to lead to retention of new word-object mappings. If this was the case we expect incorrect selections to be easily rectified through feedback. Previous work suggested this to be the case in toddlers at typical likelihood (TL) but not in those at elevated likelihood (EL) for autism spectrum disorder (ASD) (Bedford et al., 2013). Yet group differences in lexical knowledge may have confounded these findings. Here, TL (N = 29) and EL toddlers (N = 75) chose one of two unfamiliar objects as a referent for a new word. Both groups retained the word-referent mapping above chance when their choices were immediately reinforced but were at chance after corrective feedback. The same pattern of results was obtained when children observed another experimenter make the initial referent choice. Thus, children's referent choices lay memory traces that compete with subsequent correction; these strong word-object associations are not a result of children actively choosing potential referents for new words.