bluuebunny/crossref_metadata_2025 huggingface dataset:
Fatty Acid Metabolism in Endothelial Cell
Authors: Liu Bin , Dai Zhiyu
Published: September 2022

The endothelium is a monolayer of cells lining the inner of blood and lymphatic vessels. Endothelial cells (ECs) release subtracts that prevent platelet and leukocyte adhesion and aggregation and modulate blood flow, which is essential for the normal function of the vascular system. ECs play indispensable roles in angiogenesis, homeostasis, stimulus or immune response under normal physiological conditions and its dysfunction is closely associated with pathologies such as cancer, diabetes, and pulmonary hypertension. Abnormal EC metabolism, especially fatty acid dysfunctional metabolism, contributes to the leading causes of pulmonary diseases. Expanding the knowledge of ECs’ dysfunctional metabolism in disease could pave a new way for new therapeutic approaches. In this review, we focus on discussing the latest advances in EC fatty acid metabolism in health and disease, with emphasis on its roles in the pathology of pulmonary hypertension (PH).
Current patient safety issues: the role of pharmacovigilance
Authors: Zyryanov S. K. , Zatolochina K. E. , Kazakov A. S.
Published: September 2022

In the current conditions of the pandemic, the burden on the healthcare system, including the pharmacovigilance system monitoring the safety of pharmacotherapy, has significantly increased in all countries. An integral component in ensuring the safety of pharmacotherapy is the identification and prevention of the development of adverse drug reactions (ADR), which are a serious health problem worldwide. One of the modern problems of healthcare, including pharmacovigilance, was the lack of vaccines and drugs for the treatment and prevention of COVID-19 in the first waves of the pandemic, which led to the use of off-label a large number of drugs (hydroxychloroquine, azithromycin, ivermectin) for the treatment of patients with COVID-19 despite the fact that scientific data their benefits were of poor quality and based on in vitro studies. The accelerated approval of drugs and vaccines to combat the COVID-19 pandemic also highlighted the need for rapid data on the safety of drugs in the post-marketing period. However, despite the fact that pharmacovigilance is developing, it still lags behind the impressive scientific and technological achievements achieved in other areas of medicine. Unfortunately, spontaneous reporting does not assess the true prevalence of ADR well, since reporting indicators can vary significantly depending on the motivation, availability of time, qualifications, fear of punishment and similar factors of the sender. Given these known limitations of the spontaneous messaging method, additional strategies for detecting ADR are often used, including trigger tools, manual viewing of medical records and automated monitoring.
Respuesta a: ¿Es incorrecta la prevalencia de síntomas depresivos presentada en el informe de la Ensanut 2018-19?
Authors: Vázquez-Salas Ruth Argelia , Villalobos-Hernández Aremis , Barrientos-Gutiérrez Tonatiuh
Published: September 2022

No disponible
Translation of preclinical findings: The effect of low intensity repetitive Transcranial Magnetic Stimulation (rTMS) on depression score and biomarkers in patients with major depression
Authors: Leggett Kerry , Hennessy Lauren , McAndrew Mark , Price Greg , Rodger Jennifer
Published: September 2022

Background: Major depressive disorder is one of the most prevalent and costly medical conditions, with approximately 280 million people affected worldwide. It is estimated that 30-60% of individuals suffering from this disorder are treatment-resistant, not responding to psychotherapy or antidepressants. Non-invasive brain stimulation in the form of repetitive transcranial magnetic stimulation (rTMS) is often considered an alternative treatment with response rates of up to 60% in this population. However, outcomes are variable suggesting that treatment protocols remain suboptimal. Current clinical guidelines are poorly defined due to a lack of systematic evaluation when techniques were first developed. Our lab has compared a range of brain stimulation protocols in a preclinical model of treatment-resistant depression and has shown that rTMS delivered at a low intensity matches the behavioural effects obtained from the much higher intensities that are currently approved for the treatment of depression in the clinic. Structural brain changes were also observed at the lower intensity, which may lead to longer lasting beneficial effects as in seen in previous animal studies. It is hypothesised that the same outcomes will translate to patients in a clinical setting.
Methods: Participants will be recruited from patients diagnosed with Major Depressive Disorder. The study will consist of 4 to 6 weeks of treatment comprising 20-30 sessions (weekdays-only) of rTMS to the left dorsolateral prefrontal cortex. A “head-to-head trial” has been established due to ethical considerations and the need to retain the current clinical protocol. Patients will be randomly assigned to the FDA-approved standard protocol or standard protocol plus an additional low intensity stimulation group. In addition, patients will undergo psychological testing and a blood test at baseline, post-treatment and again at a 6-month follow up appointment
Discussion: This study will prospectively evaluate the antidepressant efficacy of a new rTMS parameter. Specifically, we will translate a novel low intensity rTMS protocol and compare its long-term effects to the current FDA-accredited standard protocol. We will also test the validity of blood biomarkers, including those identified in our previous animal studies, to objectively monitor individual’s response to rTMS treatment.
Trial registration: Registered with Australian New Zealand Clinical Trials Registry, prospectively registered 20/11/2018, Registration ACTRN12618001889246.
More than one quarter of Africa's tree cover found outside areas previously classified as forest
Authors: Reiner Florian , Brandt Martin , Tong Xiaoye , Skole David , Kariryaa Ankit , Ciais Philippe , Davies Andrew , Hiernaux Pierre , Chave Jerome , Mugabowindekwe Maurice , Igel Christian , Oehmcke Stefan , Gieseke Fabian , Li Sizhuo , Liu Siyu , Saatchi Sassan , Boucher Peter , Singh Jenia , Taugourdeau Simon , Dendoncker Morgane , Song Xiao-Peng , Mertz Ole , Tucker Compton J. , Fensholt Rasmus
Published: September 2022

The consistent monitoring of trees both inside and outside of forests is key to mitigating climate change. Current monitoring systems either ignore trees outside forests or are too expensive to be applied consistently across countries on a repeated basis. Here we make use of the PlanetScope nanosatellite constellation, which delivers global very high-resolution daily imagery, to map both forest and non-forest tree cover for continental Africa using images from a single year. Our prototype map of 2019 demonstrates that a precise assessment of all tree-based systems is possible at continental scale, and reveals that 29% of tree cover is found outside areas previously classified as tree cover, such as in croplands and grassland. Such accurate mapping of tree cover at metric resolution down to the level of individual trees and consistent among countries has the potential to redefine land use impacts, move beyond the need for forest definitions, build the basis for natural climate solutions, and provide a new scientific basis for tree related studies.
Psychological resilience mediates the association between childhood maltreatment and self-harm phenotype in Chinese early adolescents
Authors: Li Yuan , Li Yong-Han , He Yang , Chen Shan-Shan , Chang Jun-Jie , Yuan Meng-Yuan , Cao Lei-Lei , Wang Shao-Jie , Wang Geng-Fu , Su Pu-Yu
Published: September 2022

Self-harm (SH) increases significantly in early adolescence with great variability, and childhood maltreatment (CM) contributes to this increase. Understanding the developmental pathway from CM to SH could provide clues for SH prevention. This study used latent class analysis (LCA) to detect the phenotype of SH and explored the role of psychological resilience in the pathway from CM to SH phenotype among 5724 early adolescents (52.5% male). Three interpretable phenotypes of SH were identified: low SH (57.8%), medium SH (29.0%), and high SH (13.2%). Furthermore, CM was positively associated with the SH phenotype, psychological resilience mediated the association between CM and the SH phenotype (all ps < 0.01), and a larger mediating effect was observed in the medium SH (22.41%). Our findings offer new perspectives that improving psychological resilience can be used as an efficient intervention to reduce the risk of SH among early adolescents who have experienced CM.
Vaccination against Varicella Zoster Virus in the Spanish ophthalmological community survey. Is it time for a paradigm shift?
Authors: Sánchez-Mellado Alberto , Alcaraz-Clemente Luis , RODRIGUEZ-CALVO-DE-MORA MARINA , Ortiz-Perez Santiago , Rocha-de-Lossada Carlos
Published: September 2022

Background: There are currently two authorized vaccines against Varicella Zoster Virus (VZV) that have proved to be safe and effective in the prevention of VHZ. Ophthalmologists commonly treat Herpes Zoster Ophthalmicus (HZO) and its complications. Therefore, ophthalmologists are indeed in a privileged position to advocate for VZV vaccination. Our aim was to find out the current knowledge among Spanish ophthalmologists regarding the effectiveness of the available vaccines against VZV.Methods: A Google-Forms questionnaire was created and used as the survey platform for this study. It was an anonymous online survey of 16 questions, which was shared among Spanish ophthalmologists-in-training and consultants from April 27th, 2022, to May 25th, 2022. Results: The survey was completed by a total of 206 ophthalmology professionals from all subspecialties. We obtained responses from 17 of the 19 regions of Spain. Fifty-five percent of the respondents agreed that VZV is a frequent cause of vision loss. However, 27% of the professionals were unaware of the existence of vaccines against VZV and 71% of them did not know in which cases it could be indicated. Only 9 ophthalmologists (4%) had ever indicated vaccination against VZV in their patients. Despite this, 93% considered important to recommend vaccination against VZV in case it proved to be safe and effective. Conclusions: Considering the sequelae, complications, and the existence of safe and effective vaccines against VZV, vaccination of the target population could be considered an important public health measure. The time has come for ophthalmologists to take an active role in HZO prevention.
Comparison of proximate composition and thermal properties of Hemp and Flax fibres
Authors: Golam Sarwar AKM , Rahman Md. Atiar , Rahman M. Mostafizur , Nemoto Kazuhiro
Published: September 2022

Along with the apparel or clothing industry, diversified uses of natural lignocellulosic fibre are getting popularity in many fields e.g., composites, automotive, marines, aerospace, electronics, civil construction, nanotechnology, biomedical, etc. The property and uses of textiles are determined by their constituent fibre properties. The proximate composition and thermogravimetric analysis (TGA) data of a total of 9 local hemp and flax genotypes (3 and 6, respectively) were carried out to understand their suitability in different applications. A wide variation was observed in the ash content of hemp and flax fibres varied from 1.7 to 17.7%, Crude protein 3.27 to 9.02%, crude fibre 26.51 to 55.32%, ether extract 2.6 to 20.9% and energy value 284.44 to 383.96 kcal 100− 1 g. In TGA analysis, all the fibres showed a similar trend. The flax genotypes contain lower ash and ether extract and higher DM, crude carbohydrate and crude fibre than hemp genotypes. Therefore, flax could be used in the lightweight composite, textile, pulp and cellulose-based industries. The hemp fibre had higher ash which was reflected by a higher residue at 500 0C in TGA analysis. To understand the viability of these flax fibres, further investigations are needed.
Atomized droplet size prediction for supersonic atomized water drainage and natural gas extraction
Authors: Liu Chengting , He Liang
Published: September 2022

In the late stage of natural gas reservoir exploitation, the energy of the gas reservoir decreases sharply, the wellbore pressure decreases, the liquid accumulation is serious, and the natural gas production decreases sharply. The influence of gas working parameters on the atomization effect and liquid carrying rate was established, and the physical model of the new atomizing nozzle was established. Through laboratory experiments, the experimental parameters of gas flow rate, liquid phase flow rate, liquid phase inlet diameter and average droplet diameter SMD were obtained. Then the BP neural network atomization model optimized by genetic algorithm is established, and the Matlab is used to train the 45 groups of data sets before the experiment. After the model training, the normalized atomization parameters are trained for sensitivity analysis. The relationship between the strength and strength of the factors affecting SMD is as follows: gas flow > liquid inlet diameter > liquid phase flow. The last 15 sets of data sets outside the training samples were tested by BP and GA-BP model, and the size of SMD was predicted. The experimental results show that the determination coefficient R2 of the established GA-BP network model to the experimental parameters is 0.979 and the goodness of fit is high; the MSE, MAE and MAPE of the predicted value of GA-BP atomization model and the experimental value are 4.471, 1.811 and 0.031 respectively, the error is small, the prediction accuracy is high, and the establishment of the model is accurate. The GA-BP model plays an important role in setting the working condition parameters and predicting the droplet size, and has a certain guiding significance for solving the problem of wellbore fluid accumulation and improving the drainage efficiency.
SVMs-SKSM: Protein Function Multi-label Classification based on SVM-SVM classifiers Fusion and sequences kernel similarity matrix
Authors: Gao Ruibo , Ye Kang
Published: September 2022

Background: The assignment of function to proteins at a large scale is essential for understanding the molecular mechanism of life. However, in UniProtKB, only a very small percentage of the proteins have Gene Ontology (GO) annotations supported by experimental evidence, and some proteins may be performing different reactions and can hence be directly associated with multiple functions. Methods: To achieve more accurate classification, in this paper, we propose a multilabel classification method based on SVM-SVM classifiers fusion strategy and sequences kernel similarity matrix (named SVMs-SKSM). Firstly, we employ position specific scoring matrix (PSSM) and Gaussian Kernel similarity to get the similarity information between sequences, and introduce deep autoencoders to obtain structures interaction information. Secondly, we obtain the class probabilities features of sequences by the maximum similarity probability, and gain the class probabilities features of structures by SVM classifier. Lastly, we fuse the two class probabilities by the linear combination, and input the fused probabilities into a multi-label SVM to classify. Results: The experimental results indicate that the proposed method achieves superior performance with the accuracy of 40.7%, 34.2% and 44.5% in Level1, Level2and Level3 of yeast networks, and 54.6%, 54.4% and 57.1% in MF[101-300], BP[101-300]and CC[101-300] of human networks.Conclusions: In future work, we will consider improving feature extraction as well as building advanced prediction models to achieve higher prediction accuracy.
Sex differences in pulmonary and systemic vascular function at rest and during exercise in healthy older adults
Authors: Sless Ryan , Wright Stephen , Bentley Robert , Valle Felipe , Mak Susanna
Published: September 2022

Our aim was to conduct a sex-disaggregated analysis of pulmonary and systemic vascular function in healthy individuals both at rest and during submaximal exercise. Healthy individuals underwent right-heart catheterization at rest and during submaximal cycling. Hemodynamic data were collected in a control state and with moderate exercise. Pulmonary and systemic vascular variables including: compliance, resistance, and elastance were calculated, indexed to body surface area (BSA), adjusted for age and compared between male and female sex. Thirty-six individuals (18M/18F; 54±7 vs. 58±6 years, p=0.04) were included. When adjusted for age and indexed to BSA, total pulmonary resistance (TPulmR) (516±73 vs. 424±118 WU•m-2, p=0.03) and pulmonary arterial elastance (PEa) (0.41±0.1 vs. 0.32±0.1 mmHg•mL-1•m2, p=0.03) were higher in females vs. males. Both pulmonary (Cpa) and systemic compliance (Csa) were lower in females vs. males however lost significance with adjustment for age. Systemic arterial elastance (SEa) was higher in females (1.65±0.29 vs. 1.31±0.24 mmHg•mL-1, p=0.05). Secondary analyses demonstrated significant correlations between age and PVR (r=0.33, p=0.05), TPulmR (r=0.35, p=0.04), Cpa (r=-0.48, p<0.01), and PEa (r=0.37, p=0.03). During exercise, there were greater increases in TPulmR (p=0.02) and PEa (p=0.01) in females vs. males. TPulmR and PEa are significantly higher at rest and exercise in females vs. males. Cpa and Csa were lower in females, however this may have been confounded by age. Our results are consistent with the notion that indices of pulmonary and systemic vascular load are increased related to both older age and female sex.
Loss of INI1 inhibits the expression of SIDT1 and promotes tumor progression in skull base chordoma by regulating EZH2-mediated H3K27me3
Authors: Zhang Yazhuo , Shen Yutao , Li Mingxuan , Xiong Yujia , Ma Tianshun , Bai Jiwei , Li Chuzhong
Published: September 2022

Integrase interactor 1 (INI1) loss is associated with a poor prognosis of skull base chordoma, while the molecular mechanism remains generally unclear. Hence, we herein explored the regulatory mechanism underlying INI1 action in skull base chordoma. We exploited transcriptomic sequencing of 48 skull base chordomas to analyze theINI1-correlated genes, and we found thatEZH2was negatively correlated withINI1. As EZH2 regulated the expression of the repressive histone mark H3K27me3, we applied chromatin immunoprecipitation (ChIP) sequencing of H3K27me3 to investigate the downstream molecules involved. ChIP sequencing and ChIP-qPCR revealed that H3K27me3 directly bound to theSIDT1promoter, and qRT-PCR verified that H3K27me3 suppressed the transcription ofSIDT1. The expression of SIDT1 in skull base chordoma was assessed using immunohistochemical staining and its low expression was associated with a poor prognosis in chordoma patients. When the potential tumor-suppressive effects ofSIDT1 were further investigatedby cytologic experiments, our results verified that SIDT1 played a tumor-suppressive role in chordoma both in vitro and in vivo. In conclusion, these findings suggested the INI1-EZH2-H3K27me3-SIDT1 axis as a possible novel therapeutic target in skull base chordoma.
The functional impact of two variants of uncertain significance in TNFAIP3
Authors: Wang Li , Gan Rui , An Yunfei , Zhao Xiaodong , Tang Xuemei , Wu Junfeng
Published: September 2022

Purpose Mutations in TNFAIP3 have recently been recognized as critical cause leading to early-onset autoinflammatory and autoimmune syndrome. And gradually more TNFAIP3 gene mutations were reported, most were frameshift and truncation mutations, and only a few were missense mutations. Here, we reported five Chinese patients manifested with unclassified autoinflammatory syndrome which exhibit two identical novel missense heterozygous variants of uncertain significance (VUS) mutations in TNFAIP3 and verified their pathogenicity.
Methods We analyzed the clinical, genetic, and immunological features of five Chinese patients with two novel missense heterozygous VUS in TNFAIP3, and verified their pathogenicity.
Results We identified two missense heterozygous mutations ( c.208 G>A, p.Asp70Asn and c.770 T>C, p.Phe257Ser), which were located in the highly conserved residue of amino-terminal ovarian tumor (OTU) domain of TNFAIP3. Only the p.Asp70Asn mutation changes the structure of TNFAIP3 but both variants alter the expression of A20 in peripheral blood mononuclear cells (PBMCs). Accordingly, in vitro TNF-α stimulated patients’ PBMCs showed higher levels of p65 NF-kB phosphorylation and increased IkBα degradation, as well as increased production of the proinflammatory cytokines IL-1β, IL-18 and TNF-a after lipopolysaccharide (LPS) stimulation in vitro
Conclusion our data further expands the understanding of the HA20 disease.andhighlights the necessity of functional analysis to evaluate the pathogenicity of VUS in TNFAIP3 for accurate diagnose of HA20.
Identification of an emerging cucumber virus in Taiwan using Oxford nanopore sequencing technology
Authors: Dong Zi-Xuan , Lin Chian-Chi , Chen Yuh-Kun , Chou Chia-Cheng , Chen Tsung-Chi
Published: September 2022

Background
In June 2020, severe symptoms of stunting, leaf mosaic and fruit malformation were observed on greenhouse-grown cucumber plants in Xizhou Township of Changhua County, Taiwan. An unknown virus, designated CX-2, was isolated from a diseased cucumber sample by single lesion isolation on Chenopodium quinoa leaves. Identification of CX-2 was performed. Moreover, the incidence of cucumber viruses in Taiwan was also investigated.
Methods
Transmission electron microscopy was performed to examine virion morphology. The portable MinION sequencer released by Oxford Nanopore Technologies was used to detect viral sequences in dsRNA of CX-2-infected leaf tissue. The whole genome sequence of CX-2 was completed by Sanger sequencing and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) with species-specific primers and indirect enzyme-linked immunosorbent assay (ELISA) with anti-coat protein antisera were developed for virus detection in the field.
Results
Icosahedral particles about 30 nm in diameter were observed in the crud leaf sap of CX-2-infected C. quinoa plant. The complete genome sequence of CX-2 was determined as 4577 nt long and shared 97.0-97.2% of nucleotide identity with that of two cucumber Bulgarian latent virus (CBLV) isolates in Iran and Bulgaria. Therefore, CX-2 was renamed CBLV-TW. In 2020–2022 field surveys, melon yellow spot virus (MYSV) had the highest detection rate of 74.7%, followed by cucurbit chlorotic yellows virus (CCYV) (32.0%), papaya ringspot virus virus watermelon type (PRSV-W) (10.7%), squash leaf curl Philippines virus (SLCuPV) (9.3%), CBLV (8.0%) and watermelon silver mottle virus (WSMoV) (4.0%). Co-infection of CBLV and MYSV could be detected in field cucumbers.
Conclusions
The emerging CBLV-TW was identified by nanopore sequencing. Whole genome sequence analysis revealed that CBLV-TW is closely related, but phylogenetically distinct, to two known CBLV isolates in Bulgaria and Iran. Detection methods including RT-PCR and indirect ELISA have been developed to detect CBLV and to investigate cucumber viruses in central Taiwan. The 2020–2022 field survey results showed that MYSV and CCYV were the main threats to cucumbers, with CBLV, SLCuPV and WSMoV were occasionally occurring. Co-infection of CBLV and MYSV severely affected cucumber plants, suggesting a synergistic effect of CBLV and MYSV.
Genome-wide identification and analysis of glyceraldehyde-3-phosphate dehydrogenase family reveals the role of GmGAPDH14 to improve salt tolerance in soybean (Glycine max L.)
Authors: Zhao Xunchao , Hong Huilong , Wang Jie , Zhan Yuhang , Teng Weili , Li Haiyan , Li Wenbin , Li Yonguang , Zhao Xue , Han Yingpeng
Published: September 2022

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential key enzyme in glycolytic metabolic pathway, and plays an important role in plant growth and stress responses. In this study, sixteen GmGAPDH genes were identified on nine soybean chromosomes, which were classified into three clusters. Meantime, all GmGAPDH gene harbor two highly conserved domain, including Gp_dh_N (PF00044) and Gp_dh_C (PF02800) domain. The qRT-PCR analysis showed that most GmGAPDH genes were significantly responded to multiple abiotic stresses, including NaHCO 3 , PEG, Cold, Salt. Among them, GmGAPDH14, which was extraordinarily induced to salt stress. The GmGAPDH14 gene was cloned and overexpressed in yeast and soybean hair root. We found the GmGAPDH14 overexpressing yeast grew better than the control (pYES3 empty vector) under salt stress. The GmGAPDH14 gene overexpressed transgenic soybean plants also showed better growth than control plants. Moreover, the transgenic plants overexpressing GmGAPDH14 gene had higher activities of peroxidase (POD) and superoxide dismutase (SOD), and higher proline (Pro) level, but lower malonaldehyde (MDA) content than control plants under salt stress. Meantime, four haplotypes were found for GmGAPDH14 gene and haplotype 2, 3 and 4 were beneficial haplotype for soybean resistance to the salt stress. These results suggest that the GmGAPDH14 gene might be involved in the process of soybean tolerance to salt stress in soybean.
Intracranial carotid artery calcification patterns and ischemic stroke: a novel marker for stroke etiology?
Authors: Mazzacane Federico , Bello Beatrice Del , Ferrari Federica , Persico Alessandra , Rognone Elisa , Pichiecchio Anna , Padovani Alessandro , Cavallini Anna , Morotti Andrea , Arba Francesco
Published: September 2022

Intracranial carotid artery calcifications (ICAC) are a common finding on non-contrast computed tomography (NCCT) and have been associated with an increased risk of ischemic stroke. Intimal, medial, and mixed subtypes of ICAC have been recognized, but no data are available about the association between ICAC patterns and stroke etiology. The aim of our study was to investigate the association between ICAC patterns and etiological subtypes of ischemic stroke. We retrospectively analyzed a single center cohort of patients admitted for ischemic stroke with known etiology. Patients with a first ischemic stroke with lacunar, cardioembolic or atherothrombotic large artery disease etiology were included. Each carotid artery was evaluated separately on NCCT scans to define the ICAC pattern. The association of ICAC patterns and stroke etiology was investigated using two logistic regression models adjusting for confounders. A total of 300 patients were included in the analysis, mean age 78 years (+-10), 158 (53%) female, median NIHSS 6 (IQR 9). Prevalence of medial, intimal, and mixed calcification was: 73%, 17% and 11% in cardioembolic stroke, 66%, 25% and 9% in large artery atherosclerosis stroke and 37%, 44% and 19% in lacunar stroke (p < 0.001). After adjustment for confounders, intimal pattern (OR = 2.14; 95%CI = 1.07–4.30), and medial pattern (OR = 0.33; 95CI%=0.16–0.67) remained independently associated with lacunar stroke etiology. In conclusion, our study suggests that intimal ICAC pattern is associated with lacunar stroke, and, if validated in further studies, it may serve as a marker for lacunar stroke etiology.
MVM-LBP: Mean−Variance−Median based LBP for face recognition
Authors: Arora Nitin , Sucharitha G. , Sharma S C
Published: September 2022

This paper proposes a novel descriptor called Mean-Variance-Median based LBP (MVM-LBP). The Median binary pattern (MBP) calculates the difference between median of all the pixels in a 3 × 3 pixel window and respective eight neighbours is used. The main draw back of MBP is that two different pixel windows can have same MBP code which is not appropriate in face recognition systems. To improve the performance of the system, the proposed descriptor (MVM-LBP) involves more statistics and uses the mean, variance, and median values of all the pixels in a 3 × 3 pixel window to get a more robust feature vector. To check the excellence the of the proposed descriptor, the proposed method is applied on two publicly available facial data sets AT&T, and faces94. The outcomes show that the proposed descriptor gives encouraging results.
A Cross-sectional Survey of Public Knowledge of the Monkeypox Disease in Nigeria
Authors: Al-Mustapha Ahmad Ibrahim , Sikiru Nafisah Ayinde , Kolawole Barakat , Oyewo Muftau , Ahmed Hager , Odukoya Adesoji , Ogundijo Olwaseun Adeolu , Asiegbu Emmanuella Chinenye , Nanven Magdalene B , Lawal-Atolagbe Taibat , Lawal-Lah Fatima , Awoyale Oladayo David , Abubakar Ahmed Tijani , Sahabi Kabiru , Babandi Zaharadeen Z
Published: September 2022

Recently named a global health emergency by the World Health Organization, the Monkeypox Disease (MPXD) has gained attention due to its widened geographical distribution outside of Africa and also due to the novel sexual transmission route. The index case in Europe was from a Nigerian traveler. This study assessed public awareness and knowledge of the MPXD by conducting an online, cross-sectional survey of educated Nigerians. The study participants were recruited using the snowball sampling method between the 16 th to 29 th of August 2022. A total of 822 Nigerians were included in this study. More responses were retrieved from the Northeastern geopolitical region (30.1%, n = 220) than other regions. Our study participants had high awareness of MPXD (89%, n = 731/822) but only 58.7% (n = 429/731) of them had good knowledge of MPXD with a mean knowledge score of 5.31 ± 2.09. The main knowledge gaps were in the incubation period of the disease, the signs and symptoms, its mode of transmission, and preventive practices needed to curb the spread of the monkeypox virus (MPXV). Specifically, only 24.48% (n = 179) knew that MPXV can be transmitted via sexual contact. Most of the study participants (79.2%, n = 651) opined that we can prevent the occurrence of public health emergencies in the future. The multivariable logistic regression analysis revealed that the male gender (OR: 1.69; 95% CI: 1.22,2.33); Ph.D. level education (1.44; 95% CI: 0.48,4.23); and being homosexual (OR:1.65; 95% CI: 0.71,3.78) were significantly associated with good knowledge of MPXD. Despite the varying prevalence across the country, the region of residence within Nigeria did not influence the knowledge of MPXD among the respondents. Despite the high educational status of the majority of our respondents, there were key gaps in the public knowledge of the MPXD in Nigeria. Therefore, public health risk communication must be intensified with a focus on modes of transmission and the preventive measures needed to curb the spread of the MPXV using an integrated one-health approach.
A Personalized Short Video Recommendation Method Based on Multimodal Feature Fusion
Authors: Li Hui , Lin Jingchen , Wang Tai , Zhang Li , Wang Peng
Published: September 2022

In order to achieve accurate parsing of multiple elements of short videos, multimodal short video processing with text, image, and speech as the three elements needs to be realized. Specifically, text information is the external marker data presented by short videos, and text information retrieval can currently be achieved by crawler crawling technology. Image information is the frame data extracted from the short video at certain time intervals by means of frame processing, and there are many types of image formats. The frame structure and pixel composition of different types of image files are completely different. Voice information is the stereo background music present in short videos, and this music voice also has different formats. Different voice formats also require different technical processing. Therefore, for short video recommendation techniques, the processing results of the above three text, image, and voice information need to be fully understood and analyzed comprehensively in order to come up with the best recommendation results. In this paper, based on multimodal content analysis techniques, we propose a framework for integrated processing of the three elements of information of short videos to form a unified information representation and to realize the elemental processing of the three elements of multimodal short videos at the semantic level. Multimodal content analysis plays an important role in short video recommendation applications. In this paper, a multimodal data fusion short video recommendation method is proposed, in which the key issue is how to effectively combine information from different modalities in order to provide recommendations to users with target information. The method not only considers user behavior features and short video label features, but also maps video from high-dimensional space to low-dimensional dense space, and extract the short video word vector features. At the same time, we consider that there is a relationship between the user's clicking behavior and the short video cover image and profile. The short video image features and text features are fused with the structured features and trained together to complete the short video recommendation task. The method makes full use of the differences and similarities between different models to increase the model's understanding of user behavior and improve the short video recommendation.
Effect of Container Volume and Planting Density on Ginger and Turmeric Growth and Yield
Authors: Retana-Cordero Marlon , Flores Sofia J. , Fisher Paul R. , Freyre Rosanna , Gómez Celina
Published: September 2022

Domestic production of ginger (Zingiber officinale) and turmeric (Curcuma longa) rhizomes is increasing. The objective of this study was to compare growth and rhizome yield of these crops using different container volumes and planting densities. Two greenhouse experiments that lasted 28 weeks each were conducted. In Expt. I, one sprouted rhizome of a single ginger variety (Bubba Blue) and four turmeric varieties (Hawaiian Red, BKK, White Mango, and Black) were transplanted into either small (1.5 gal) or large (13.3 gal) round containers. In Expt. II, either one or three sprouted rhizomes of two ginger varieties (Bubba Blue and Madonna) and two turmeric varieties (Indira Yellow and Hawaiian Red) were transplanted into either large (13.3 gal) or medium (3.9 gal) round containers. In Expt. I, there were an increase in plant growth and yield with increasing container volume, as both crops produced more than double the shoot, root, and rhizome fresh weight (FW) when grown in large compared with small containers. In Expt. II, rhizome yield of ginger was 44% higher in medium than large containers, and container volume did not affect yield in turmeric. Total dry weight (DW) was higher in plants grown in the larger container volume in both species in Expt. I, and turmeric only in Expt. II. However, ginger in Expt. II had an 18% higher plant DW in the medium compared with the large container. The higher density in Expt. II increased yield and biomass production per container compared with the lower density, regardless of variety and container volume. Overall, net revenue per container was higher in Expt. II than Expt. I because of the higher rhizome yield. In Expt. I, the higher yield of ginger compared with turmeric increased sales revenue of this species, despite a lower sales price per kilogram. In contrast, the higher yield of turmeric in Expt. II resulted in higher sales revenue and net revenue per container compared with ginger. Based on our results, medium containers could be used to minimize material and space costs for ginger and turmeric production under the conditions evaluated in our study.
Preparation and characterization of polyethyleneimine functionalized magnetic graphene oxide as high uptake and fast removal for Hg (II)
Authors: Wang Deqi , Ge Huacai
Published: September 2022

Polyethyleneimine functionalized magnetic graphene oxide adsorbent (PEI-mGO) was synthesized by introducing polyethyleneimine onto Fe3O4/graphene oxide. The structures and morphologies of PEI-mGO was identified by using Fourier-tranform infrared (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and vibrating sample magnetometer (VSM) methods. Quantities of bar-like Fe3O4 nanoparticles were observed on the surfaces of PEI-mGO. The adsorption of PEI-mGO for Cu(II), Pb(II), Hg(II), Co(II) and Cd(II) was compared. The adsorption results indicated that PEI-mGO showed higher uptake for Hg(II) than the other ions. The influence of various variables for the adsorption of Hg(II) on PEI-mGO was explored. The adsorption kinetics and isotherm could be described well by the pseudo-second-order and Langmuir models. The maximal uptake of PEI-mGO for Hg(II) from Langmuir model was 857.3 mg g−1, which was higher than that reported previously. The adsorption removal was a fast and endothermic process governed by the chemical process. The uptake increased with increasing temperature. PEI-mGO showed an excellent performance for removal of Hg(II) with 93.3% removal efficiency from simulated wastewater. Adsorption-desorption cycled experiments indicated that PEI-mGO could be recycled. PEI-mGO could be easily separated from the adsorbed solution by using a magnet. Hence, this novel adsorbent would be promising for the removal of Hg(II) from wastewater.
Characterization Linguistic policies around Peruvian Sign Language (PSL)
Authors: Galloso Cossios Rodrigo Saniel , Candela Tenorio Dallely Alexandra , Vega Vicente Josseline Yanniré
Published: September 2022

The main objective of this article is to analyze the linguistic policies regarding a viso-gestural language: Peruvian Sign Language or LSP. Currently, the Ministry of Culture oversees the linguistic policies of the country’s native languages; however, although LSP could be considered native, it is not and does not fall under the linguistic policies of the Ministry of Culture. On the other hand, the Ministry of Women oversees the LSP language policies; however, it has not worked much in favor of the LSP. The article concludes that if the LSP were considered a native language, many gaps in language policies could be resolved.
Heliotropium, an Ethnomedicinal Plant: Past and Present Uses
Authors: Donoso-Fierro César , Becerra José , Rojas-Leyton Claudio , Pérez Claudia
Published: September 2022

The genus Heliotropium is formed of herbaceous plants belonging to the
family Boraginaceae. In Chile and around the world, many Heliotropium species are
commonly used in traditional and complementary medicine to treat various diseases.
Members of this genus are also recognized for unique biosynthesized phytochemicals,
mainly terpenoids, phenolics and alkaloids. Due to important phyto-constituents, as
well as their therapeutic potential, many Heliotropium species have been subjected to
chemical, biological and pharmacological investigations. This review details the many
ethnomedicinal uses for Heliotropium, with an emphasis on Chilean species, and
analyzes their scientific validation based on the chemical constituents and
pharmacological properties of Heliotropium reported in academic publications. In
addition, we discuss the critical conclusions, as well as some suggestions for future
phytochemical and biological studies with Heliotropium species.
PENDIDIKAN KARAKTER MELALUI PENGEMBANGAN BUDAYA SEKOLAH DI SEKOLAH ISLAM TERPADU SALMAN AL FARISI YOGYAKARTA
Authors: Khairudin Moh. , . Susiwi
Published: September 2022

Abstrak: Penanaman pendidikan karakter sejak dini merupakan harga paling mahal yang perlu dibayar oleh orang tua pada anaknya. Semua karakter yang melekat pada masa anak-anak akan menjadi karakter dan budaya yang kuat dalam sanubari anak. Sekolah Islam Terpadu (SIT) Salman Al Farisi Yogyakarta sebagai salah satu entitas masyarakat menyelenggarakan pendidikan dasar. Metode yang dikembangkan dalam pendidikan karakter adalah melalui penumbuhan budaya sekolah. SIT Salman Al Farisi Yogyakarta melakukan penumbuhan budaya sekolah untuk mendapatkan hasil belajar pada aspek budaya yang memuaskan stakeholder. Nilai budaya yang menjadi trade mark SIT Salman Al Farisi Yogyakarta adalah integratif, produktif, kreatif dan inovatif, qudwah hasanah, kooperatif, ukhuwah, rawat, resik, rapi dan sehat, dan berorientasi mutu. Nilai budaya tersebut telah dituangkan dalam prosedur pelaksanaan sampai dengan petunjuk pelaksanaannya. Hal ini menjadikan SIT Salman Al Farisi siap mengimplementasikan nilai-nilai budaya tersebut pada semua warga sekolah dan orang tua siswa. Kata Kunci: budaya sekolah, Islam terpadu, pendidikan karakter
THE ROLE OF BASIC DESIGN COURSE IN THE INTRODUCTION AND DEVELOPMENT OF LOCAL CULTURE VALUES
Authors: Esa Dora Purnama , G. Poetiray Maria Suzanna
Published: September 2022

Abstract: Indonesia has been known as a country which upholds cultural values and philosophy through artworks media. One of those is presented in batik. No other cloth in the Indonesian archipelago, perhaps in the world as well, contains so many symbols and meanings. But sadly, as the globalization emerges, there is a tendency to exalt developed country’s culture, and our young generation no longer cares about our own country’s cultural values. Batik is considered obsolete, not fancy, and only suitable for the old generation. In the modern design world, basic design subject may be a good tool to introduce local values while the young learn to compose the elements and design principles as design sensitivity training. One of the tasks is making a pattern composition using local content, and batik is a complex local pattern that is commonly used as inspiration. Keywords: basic design, local content, batik
PEMBENTUKAN KARAKTER BANGSA MELALUI PENDIDIKAN NILAI
Authors: Wening Sri
Published: September 2022

Abstrak: Penelitian ini bertujuan untuk (1) mengembangkan nilai-nilai kehidupan sebagai dimensi pembentuk karakter; (2) menelaah perolehan dimensi pendidikan nilai melalui faktor-faktor lingkungan; dan (3) mengungkap pencapaian pembentukan karakter melalui faktor lingkungan dan implementasi pendidikan nilai dalam mata pelajaran/kurikulum. Penelitian ini bersifat deskriptif eksploratif berdasarkan hasil evaluasi reflektif para guru mata pelajaran PKN, IPS, dan PKK dan siswa SMP di DIY. Data dianalisis menggunakan teknik analisis deskriptif, regresi dan t-test. Kesimpulan yang diperoleh adalah (1) guru menemukan 17 nilai-nilai kehidupan (pendidikan nilai) yang terkandung dalam konsep pendidikan konsumen yang merupakan dimensi pembentuk karakter; (2) siswa menjelaskan bahwa pendidikan nilai yang diperoleh dari keluarga, sekolah, teman sebaya, dan media masa cenderung cukup baik; dan (3) pendidikan nilai melalui keluarga, teman sebaya, dan media massa berpengaruh terhadap pembentukan karakter peserta didik, namun melalui sekolah tidak berpengaruh terhadap pembentukan karakter. Pembelajaran dengan menggunakan intervensi buku cerita pembelajaran nilai-nilai kehidupan dapat membentuk karakter siswa. Dalam silabus dan buku ajar terkandung sedikit dimensi pendidikan nilai. Kata Kunci: pendidikan nilai, pembentukan karakter, karakter bangsa THE NATION’S CHARACTER BUILDING THROUGH VALUE EDUCATION Abstract: This research is aimed (1) to develop life values as a dimension of character builder; (2) to study the achievement of value education dimension as a character builder through the environmental factors; (3) to reveal the achievement of character building through environmental factors and the implementation of value education in school subjects/curriculum. This research is explorative descriptive based on the result of reflective evaluation made by junior high school teachers of PKN (civics), IPS (social science), and PKK (family welfare education) and by junior high school students in the Province of Yogyakarta Special Territory. The data were analyzed using the techniques of descriptive analysis, regression and t-test. It was concluded that (1) the teachers found 17 life values (value education) consisted of the concept of consumer education and the dimensions of character builder; (2) the students stated that value education obtained from the family, school, peers, and mass media tend to be good enough; and (3) the value of education through family, peers, and mass media influenced the character formation of the students, but that through the school had no effect on character building. The teaching and learning process using the intervention of story books of life values could develop the students’ character. In addition, there was little dimension of value education in the syllabus and text books. Keyword: value education, character building, nation character
PENDIDIKAN KARAKTER DAN PEMBELAJARAN BAHASA ASING BERWAWASAN INTERKULTURAL
Authors: Santoso Iman
Published: September 2022

Abstrak: Pembelajaran bahasa asing saat ini menduduki posisi yang cukup penting dalam peta pendidikan di Indonesia. Melalui pembelajaran bahasa asing diharapkan akan terbentuk manusia Indonesia yang mampu berkomunikasi dalam bahasa asing dengan berbagai bangsa di dunia. Penguasaan bahasa Asing juga sangat diperlukan, karena akan menjadi pintu bagi bangsa Indonesia untuk menyerap perkembangan ilmu pengetahuan dari negara-negara lain. Salah satu cara agar pembelajaran bahasa Asing dapat menghasilkan output yang mampu berkomunkasi dengan baik dalam bahasa target yang dipelajari adalah melalui pembelajaran bahasa asing yang berwawasan interkultural. Bahasa dan budaya merupakan satu kesatuan yang tak bisa dipisahkan, sehingga keberhasilan pembelajaran bahasa asing juga akan dipengaruhi seberapa jauh unsur budaya dari bahasa target dapat diintegrasikan dalam pembelajaran. Di sisi lain, dalam konteks keindonesiaan, pembelajaran bahasa asing juga terikat untuk menerjemahkan amanah dalam UU No 20 Tahun 2003 tentang SISDIKNAS, yaitu kewajiban untuk turut serta membentuk manusia Indonesia yang berkarakter. Kata Kunci: pendidikan karakter, pembelajaran bahasa asing, pembelajaran interkultural CHARACTER EDUCATION AND INTERCULTURALLY ORIENTED FOREIGN LANGAGE TEACHING AND LEARNING Abstract: Today foreign language teaching and learning plays an important role in the Indonesian education system. By learning foreign languages it is expected that learners are able to communicate in languages of different countries in the world. Acquiring a foreign language also enables them to access knowledge from other countries. One of the ways to achieve this is through interculturaloriented language teaching and learning. Language and culture are inseparable and therefore the success of foreign language teaching and learning is influenced by how cultural aspects are integrated into language teaching. In the Indonesian education system, the foreign language teaching and learning has to meet the requirements set out in the National Education Act, No. 2, 2003. This act requires that the foreign language teaching also support character education. Keywords: character education, foreign language teaching and learning, intercultural learning
MENINJAU KEMBALI HUBUNGAN ANTARA SASTRA DAN BUDI PEKERTI
Authors: Budiman Manneke
Published: September 2022

Abstrak: Hubungan sastra dan budi pekerti telah lama ramai diperbincangkan orang. Ada tuntutan dalam masyarakat bahwa sastra haruslah dapat menjadi sarana pembelajaran moral dan pekerti untuk dapat dinilai sebagai karya sastra yang baik.Timbulnya banyak hujatan pada sejumlah karya sastra, baik di dalam negeri maupun dalam sejarah kesusastraan berbagai bangsa di dunia, mengukuhkan asumsi bahwa sastra yang baik adalah sastra yang diabdikan pada pendidikan moral.Tulisan ini menyoroti berbagai asumsi tersebut dengan memperlihatkan bahwa banyak karya besar dunia justru menggugat hubungan linear dan positif antara sastra dan pendidikan budi pekerti. Tulisan ini juga berargumen bahwa sastra terkadang justru berperan sebagai instrumen untuk menggugat superioritas nilai-nilai moral tertentu, serta menawarkan cara lain untuk memahami wujud hubungan antara sastra dan moralitas. Lewat sejumlah telaah atas karya-karya sastra Indonesia dan dunia, seperti sastra Jerman, dibahas kondisi hubugan antara sastra dan moralitas di Indonesia. Kesimpulan akhir yang diajukan adalah diperlukan perspektif alternatif untuk memahami kembali bentuk-bentuk relasi yang lebih setara antara sastra dan budi pekerti, sehingga sastra bisa ditempatkan secara proporsional dalam kapasitasnya sebagai agen sosialisasi moral ataupun agen perubahan moral. Kata Kunci: pembelajaran moral, sastra Indonesia, sastra dunia, sastra Jerman, hubungan sastra dan budi pekerti