bluuebunny/crossref_metadata_2025 huggingface dataset:
10% povidone-iodine versus 2% chlorhexidine gluconate for Periurethral cleansing before catheterization among hospitalized patients: A randomized controlled trial
Authors: vahabi elham , ghafari somayeh , haghighat somayeh
Published: September 2019

Background There are evidences that periurethral cleaning by antiseptics before catheterization decreases the risk of urinary tract infections. The purpose of this study was to Comparing 10% povidone-iodine and chlorhexidine gluconate (CHG) effectiveness in periurethral cleaning before catheterization on bacteriuria and pyuria in hospitalized patients. Methods A randomized controlled trial was used, and subjects were randomly allocated to either the 10% povidone -iodine group or the 2% chlorhexidine gluconate group. Urine specimens for culture and Analyse were collected 3 times for each subject within 5 days. Results Overall, 216 urine samples were collected in 72 subjects .There were no significant difference in results of bacteriuria of two groups immediately, 72 hrs. and 5 days after catheterization (p>0.05). There was no significant difference between two groups regarding positive pyuria immediately after sampling (p>0.05). Although its amount was significantly higher 72 hrs and 5days after catheterization in 10% povidone-iodine group than 2% chlorhexidine gluconate (p<0.05). In order to evaluate average of micro-organism in different time intervals between two groups Mann– Whitney test was used. This test showed that there was no significant difference of number of time intervals (p>0.05). Conclusions The results of this study showed that using 2% chlorhexidine gluconate reduced the amount of bacteriuria in catheterazied patients compared to 10% povidone-iodine. However this difference was not significant. Therefore doing more studies with more number of samples in this field is suggested. Trial registration: Retrospectively registered. IRCT20170712035044N2 Key words: 10% povidone-iodine- 2% chlorhexidine gluconate - Bacteriuria- Periurethral cleansing
IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα- BCa and AR- PCa cells and promotes cell survival
Authors: Nawas Afshan F. , Kanchwala Mohammed , Thomas-Jardin Shayna E. , Dahl Haley , Daescu Kelly , Bautista Monica , Anunobi Vanessa , Wong Ally , Meade Rachel Katherine , Mistry Ragini , Ghatwai Nisha , Bayerl Felix , Xing Chao , Delk Nikki
Published: September 2019

Background: Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Thus, BCa and PCa patients are given therapies that reduce hormone levels or directly blocks HR activity; but most patients eventually develop treatment resistance. We have previously reported that interleukin-1 (IL-1) inflammatory cytokine downregulates ER𝛼 and AR mRNA in HR-positive (HR+) BCa and PCa cell lines, yet the cells can remain viable. Additionally, we identified pro-survival proteins and processes upregulated by IL-1 in HR+ BCa and PCa cells, that are basally high in HR- BCa and PCa cells. Therefore, we hypothesize that IL-1 confers a conserved gene expression pattern in HR+ BCa and PCa cells that mimics conserved basal gene expression patterns in HR- BCa and PCa cells to promote HR-independent survival and tumorigenicity.Methods: We performed RNA sequencing (RNA-seq) for HR+ BCa and PCa cell lines exposed to IL-1 and for untreated HR- BCa and PCa cell lines. We confirmed expression patterns of select genes by RT-qPCR and used siRNA and/or drug inhibition to silence select genes in HR- BCa cell lines. Finally, we performed Ingenuity Pathway Analysis (IPA) to identify signaling pathways encoded by our RNA-seq data set.Results: We identified 350 genes in common between BCa and PCa cells that are induced or repressed by IL-1 in HR+ cells that are, respectively, basally high or low in HR- cells. Among these genes, we identified Sequestome-1 (SQSTM1/p62) and SRY (Sex-Determining Region Y)-Box 9 (SOX9) to be essential for survival of HR- BCa and PCa cell lines. Analysis of publicly available data indicates that p62 and SOX9 expression are elevated in HR-independent BCa and PCa sublines generated in vitro, suggesting that p62 and SOX9 have a role in acquired treatment resistance. We also assessed HR- cell line viability in response to the p62-targeting drug, verteporfin, and found that verteporfin is cytotoxic for HR- cell lines. Conclusions: Our 350 gene set can be used to identify novel therapeutic targets and/or biomarkers conserved among acquired (e.g. due to inflammation) or intrinsic HR-independent BCa and PCa.
Time to Change’s social marketing campaign for a new target population: results from 2017-2019.
Authors: González-Sanguino Clara , Potts Laura C , Milenova Maria , Henderson Claire
Published: September 2019

Background. Since 2009 Time to Change has included among its strategies a social marketing campaign to tackle the stigma surrounding mental health problems. At the start of its third phase (2016-2021) the target group of the campaign was kept as people aged between mid-twenties and mid-forties but changed to middle-low income groups and the content was focused on men. Methods. Participants (n = 3700) were recruited through an online market research panel, before and after each burst of the campaign. They completed an online questionnaire evaluating knowledge [Mental Health Knowledge Schedule (MAKS)]; attitudes [Community Attitudes toward Mental Illness (CAMI)]; and desire for social distance [Intended Behaviour subscale of the Reported and Intended Behaviour Scale (RIBS)]. Socio-demographic data and awareness of the campaign were also collected. Results. For each of the 3 bursts, significant pre-post awareness differences were found (OR=2.83, CI=1.90 to 4.20, p<0.001; OR=1.72, CI=1.22 to 2.42, p=0.002; OR=1.41, CI=1.01 to 1.97, p=0.043), and awareness at the end of the third burst was 33%. Demographic factors associated with awareness for one or more bursts included having children, familiarity with mental illness, male sex, being Black, Asian or other ethnic minorities and living in London or the East Midlands regions. An improvement across bursts in the “living with” subscale item of the RIBS, and in the “recover” and “advice to a friend” MAKS items were found. Familiarity with mental illness had the strongest association with all outcome measures, while the awareness of the campaign was also related with higher scores in MAKS and RIBS. Conclusions. These interim results suggest that the campaign is reaching and having an impact on its target audience. While over the course of Time to Change we have found no evidence that demographic differences in stigma have widened, and indeed those by age group and region of England have narrowed, those for socioeconomic status, ethnicity and sex have so far remained unchanged. By targeting a lower socioeconomic group and creating relatively greater awareness among men and in Black and ethnic minority groups, the campaign is showing the potential to address these persistent differences in stigma.
Fecal microbiota and metabolome characteristics in cirrhotic patients accompanied with hepatic encephalopathy
Authors: wei xiao , Yuan Jing
Published: September 2019

Background Gut microbiota is considered as an important endocrine organ and has remarkable influence on the metabolic phenotype of host, with extensive participation in the cometabolism with host. Significant changes occurred in intestinal microenvironment of cirrhotic patients under the influence of gut-liver axis. Hepatic encephalopathy is one of the common complications of cirrhosis. Methods In this study, four patients of cirrhosis accompanied with hepatic encephalopathy (CHE) were enrolled, with their healthy relatives as the controls, and paired comparison analysis was carried out. Fresh fecal samples were collected from participants, and subjected to Illumina MiSeq high throughput sequencing of 16S rRNA regions, and metabolome analysis was carried out using high-performance liquid phase chromatography and gas chromatography coupled with tandem mass spectrometry (HPLC-GC/MS-MS). Results Both the intestinal microbiota community and metabolome analysis showed distinct differences between CHE patients and the normal. CHE patients contained a remarkably decreased abundance of Bacteroidetes, whereas increased abundances of Firmicutes and Proteobacteria compared with the normal. Metabolome analysis revealed significant changes in metabolites constituents for CHE patients, showing distinct higher concentrations of amine, alanine, glutamic acid, ornithine, and tyrosine, with lower concentrations of cholesterol, myo-inositol, serine, suggesting the metabolic balance of intestinal microbiota was disrupted. The initial equilibrium state of gut microbiota community and metabolism was broken due to CHE. Conclusions Our study illustrated the intestinal microenvironment dysbiosis and dysfunction characteristics, which will be expected to provide guiding significance for intestinal microecological therapy and improvement of patients prognosis clinically.
Serum miR-101-3p combined with pepsinogen contribute to the early diagnosis of gastric cancer
Authors: Zeng Weiwei , Zhang Shuxiang , Yang Lei , Wei Wenchao , Gao Jie , Guo Ni , Wu Fengting
Published: September 2019

Background This study aimed to explore the effect of serum miR-101-3p combined with pepsinogen (PG) on early diagnosis of gastric cancer (GC).Methods The peripheral blood was isolated from patients with atrophic gastritis (AG), GC and healthy individuals respectively. RT-qPCR was used to detect the expression of miR-101-3p. Electrochemiluminescence (ECL) was used to reveal the carcinoembryonic antigen (CEA) expression level. Moreover, the expression of PGI and PGII was detected by ELISA. Furthermore, the area under the receiver operating characteristic (ROC) curve (AUC) was used to analyze the diagnostic efficacy of miR-101-3p and PG in early GC patients, AG patients and healthy individuals.Results There were significant differences in the expression levels of miR-101-3p, PGI and PGI/II ratio among groups (all P < 0.05). Serum miR-101-3p expression was correlated with process of invasion (P = 0.03). The miR-101-3p + PGI/II and miR-101-3p + PGI + PGI/PGII have higher diagnostic value (AUC) in AG (all P < 0.05). Meanwhile, miR-101-3p + PGI, miR-101-3p + PGI/II and miR-101-3p + PGI + PGI/II have higher AUC in GC (all P < 0.05). Moreover, miR-101-3p + PGI + PGI/II significantly (P < 0.05) improved the value of each indicator in individual diagnosis (sensitivity: 80.23, specificity: 77.05)Conclusions The miR-101-3p might take part in the progression of GC via influencing cell invasion. Furthermore, miR-101-3p + PG might be used as a novel marker for clinical diagnosis of GC.
NR2F2 Plays a Major Role in Insulin-induced Epithelial-Mesenchymal Transition in Breast Cancer Cells
Authors: xia Baili , Hou Lijun , Kang Huan , Chang Wenhui , Liu Yi , Zhang Yanli , Ding Yi
Published: September 2019

The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclear receptor subfamily 2, group F member 2 (NR2F2) has been implicated in the development of breast cancer, however its contribution to insulin- induced EMT in breast cancer remains unclear. Overexpression and knockdown of NR2F2 was used in two breast cancer cell lines, MCF-7 and MDA-MB-231 to investigate potential mechanisms by which NR2F2 leads to insulin-mediated EMT. Insulin stimulation of these cells increased NR2F2 expression levels and promoted invasion and cell migration accompanied by alterations in EMT-related molecular markers. Overexpression of NR2F2 and NR2F2 knockdown demonstrated that NR2F2 expression was positively correlated with cell invasion, migration and the expression of N-cadherin and vimentin. In contrast,, NR2F2 had an inverse correlation with E-cadherin expression. In MDA-MB-231, both insulin-induced cell invasion and migration and EMT-related marker alteration were abolished by NR2F2 knockdown. These results suggest that NR2F2 plays a critical role in insulin-mediated breast cancer cell invasion, migration through its effect on EMT.
Tumour necrosis factor-α(-308) polymorphism and the risk of gastric cancer: A meta- analysis and trial sequential analysis
Authors: Naing Cho , Tung Wong Siew , Htet Norah Htet , Palayan Kandasami , Win Thin Thin , Mak Joon Wah
Published: September 2019

Background: Numerous studies have reported that polymorphisms in the tumour necrosis factor-alpha (TNF-a-308) gene are implicated in susceptibility to gastric cancer. However, individual genetic association studies that assessed the relationship between TNF-a- 308 and the risk of gastric cancer showed inconclusive results. The objective of this study was to synthesis evidence on the association between polymorphisms in the TNF-a-308 and gastric cancer risk.
Methods: This is a meta-analysis of genetic association studies. We searched relevant case-control studies, assessing TNF- 308 polymorphisms and gastric cancer in health-related electronic databases. The methodological quality of included studies was assessed by the Newcastle-Ottawa quality assessment scale. The strength of association was calculated as odds ratios (ORs) with its 95% confidence intervals (CIs). Pooled ORs and 95 % CIs were estimated using random-effect model or fixed effect model, based on between-study heterogeneity. We analysed the strength of association under dominant, recessive, additive and allele models. Multiple subgroup analyses including ethnic groups, HWE status, study quality were done for robustness of the estimates. Publication bias was detected by inspection of funnel plot asymmetry.
Results: A total of 33 studies, comprising 7695 patients and 12327 controls were identified. Based on the studies that met HWE, significant association was found between this polymorphisms and gastric cancer risk under dominant model (OR 1.2, 95%CI 1.1-1.3, I 2 :37%), recessive model OR 1.27, 95%CI 1.0-1.62, I 2 :0%) and additive model (OR 1.31, 95%CI 1.08-1.32, I 2 :0%). The TSA plot indicated the analyses was with the required information size. There was no publication bias. In the subgroup analysis by ethnicity, the ethnic groups and the quality of studies had impact on the estimates.
Conclusions: The findings suggest that TNF-α-308 gene polymorphism plays an important role as host genetic factor predisposing to gastric carcinogenesis, and it would be useful for a screening marker.
Ghd8 controls rice photoperiod sensitivity by forming a complex that interacts with Ghd7
Authors: Wang Peng , Gong Rong , Yang Ying , Yu Sibin
Published: September 2019

Background: Flowering time is one of the most important agronomic characteristics that ultimately determine yield potential and eco-geographical adaptation in crops. Ghd8 and Ghd7, two major flowering genes, have similar functions and large pleiotropic effects in controlling the heading date, plant height and grain yield of rice. However, these gene interactions at the genetic and molecular levels have not been determined to date. Results: In this study, we investigated the genetic interaction between Ghd8 and Ghd7 by using a set of near-isogenic lines and a panel of natural germplasm accessions in rice. We found that Ghd8 affected multiple agronomic traits in a functional Ghd7-dependent manner. Both functional Ghd8 and Ghd7 are pivotal for rice photoperiod sensitivity controlled by Hd1 and Hd3a. GHD8 could form a heterotrimeric complex with HD1 and OsHAP5b to activate the transcription of Ghd7 by binding directly to the promoter region of Ghd7, which contains the CCAAT-box motif. Conclusions: The results of this study help to elucidate the genetic and molecular bases of Ghd8 and Ghd7 interactions, indicating that Ghd8 acts upstream of Ghd7 to activate its transcription, which inhibits Hd3a expression and thus affects flowering time and rice adaptation.
Optimum suspension design for non-linear half vehicle model using particle swarm optimization (PSO) algorithm
Authors: Yildiz Ahmet
Published: September 2019

This paper is considered with a non-linear suspension design for half vehicle model by using particle swarm optimization technique. To analyze the ride comfort, a five-degree of freedom system is built, and it is integrated with the Particle Swarm Optimization (PSO) for optimizing the vehicle vibrations. A multi-objective function is proposed as the sum of the minimum seat and vehicle body acceleration, the minimum suspension deflection and the constraints and the design variables of the optimization problem are selected as the spring and damping coefficients of the front and rear suspension and the non-linear spring and the linear damping coefficients of the seat. The simulations are carried out and the results are compared with the non-optimized values. It is demonstrated that the vehicle vibration is decreased significantly with the help of the optimum values of the suspension parameters.
Image defined risk factors in patients with neuroblastoma. Literature review
Authors: Ternovaya E. S. , Kachanov D. Yu. , Shamanskaya T. V. , Shcherbakov A. P. , Varfolomeeva S. R. , Rubtsova N. A. , Tereshchenko G. V.
Published: September 2019

Currently, two staging systems are used: the International Neuroblastoma Staging System (INSS), which relies on surgical staging, and the International Neroblastoma Risk Group Stading System (INRGSS), which relies on preoperative imaging for staging and image-defined risk. The article presents a review of the literature on image defined risk factors (IDRF) determined during radiological studies (computed tomography and magnetic resonance imaging) in patients with neuroblastoma. The article focuses on the definition of IDRFs, their prevalence and their influence on surgical outcomes and prognosis of patients with neuroblastoma.
Cryopreservation of ovarian tissue in girls with oncological diseases: a multidisciplinary approach
Authors: Dinikina Yu. V. , Belogurova M. B. , Govorov I. E. , Gamzatova Z. Kh. , Pervunina T. M. , Komlichenko E. V.
Published: September 2019

The issues concerning quality of life are becoming increasingly important with the improvement of survival rates in children with cancer. The possibility of minimizing the toxicity of antitumor therapy for various organs and systems without reducing the effectiveness of specific therapy, as well as the development of preventive measures, is now an important task of medical specialists. Gonadal toxicity is a frequent adverse event that negatively affects both the somatic and psychological and emotional state of the cured patients. The only prospect of reproductive function preserving in a cohort of prepubertal girls with a high risk of premature ovarian failure is the ovarian tissue cryopreservation. The main goal of this publication is to emphasize the importance of the reproductive health problem of girls with oncological diseases, with a description of the current data of international literature on the prospects of ovarian tissue cryopreservation in order to preserve fertility. Another goal is to present a multidisciplinary strategy for the management of prepubertal age patients with oncological disease within the framework of the Oncological Fertility Project at Almazov National Medical Research Center. Based on the data of Russian and international literature, as well as existing guidelines and recommendations on reproductive health, a single algorithm for selecting patients has been developed, considering the expected gonadal toxicity for the use of the ovarian cryopreservation method in prepubertal girls. Carrying out of all the steps is possible in the optimal terms of antitumor therapy in the conditions of one hospital with observance of the stages of medical aid provision. The developed algorithm will allow to identify patients of prepubertal age, requiring the use of modern possibilities of reproductive technologies. In long-term date we are planning to evaluate the effectiveness of the orthotopic reimplantation technique for cryopreserved ovarian tissue in order to realize the reproductive function. A multidisciplinary team of specialists and the possibilities of the federal center fully allow to realize the Oncofertility Program in daily practice for girls and young women who needs to undertake gonadotoxic treatment.
Case of successful treatment of neuroaspergillosis in oncological patient
Authors: Izmozherova R. I. , Kuleva S. A. , Ivanova S. V. , Faseeva N. D. , Tyatkov S. A.
Published: September 2019

Invasive mycoses caused by fungi of the genus Aspergillus, today remain an urgent clinical problem in oncological patients. In 10–20 % of patients with primary by aspergilloma can be detected in the Central nervous system. The article describes a case of neuroaspergillosis in an immunocompromised patient with choroid carcinoma of the right parietal-occipital lobe of the brain. Correct interpretation of risk factors, clinical symptoms and imaging techniques, early diagnosis with verification the pathological process, the use of fungistatic and fungicidal drugs allowed to avoid the negative consequences of fungal neuroinfection.
Tracking and Predicting Depressive Symptoms of Adolescents Using Smartphone-Based Self-Reports, Parental Evaluations, and Passive Phone Sensor Data: Development and Usability Study
Authors: Cao Jian , Truong Anh Lan , Banu Sophia , Shah Asim A , Sabharwal Ashutosh , Moukaddam Nidal
Published: September 2019

Background

Depression carries significant financial, medical, and emotional burden on modern society. Various proof-of-concept studies have highlighted how apps can link dynamic mental health status changes to fluctuations in smartphone usage in adult patients with major depressive disorder (MDD). However, the use of such apps to monitor adolescents remains a challenge.

Objective

This study aimed to investigate whether smartphone apps are useful in evaluating and monitoring depression symptoms in a clinically depressed adolescent population compared with the following gold-standard clinical psychometric instruments: Patient Health Questionnaire (PHQ-9), Hamilton Rating Scale for Depression (HAM-D), and Hamilton Anxiety Rating Scale (HAM-A).

Methods

We recruited 13 families with adolescent patients diagnosed with MDD with or without comorbid anxiety disorder. Over an 8-week period, daily self-reported moods and smartphone sensor data were collected by using the Smartphone- and OnLine usage–based eValuation for Depression (SOLVD) app. The evaluations from teens’ parents were also collected. Baseline depression and anxiety symptoms were measured biweekly using PHQ-9, HAM-D, and HAM-A.

Results

We observed a significant correlation between the self-evaluated mood averaged over a 2-week period and the biweekly psychometric scores from PHQ-9, HAM-D, and HAM-A (0.45≤|r|≤0.63; P=.009, P=.01, and P=.003, respectively). The daily steps taken, SMS frequency, and average call duration were also highly correlated with clinical scores (0.44≤|r|≤0.72; all P<.05). By combining self-evaluations and smartphone sensor data of the teens, we could predict the PHQ-9 score with an accuracy of 88% (23.77/27). When adding the evaluations from the teens’ parents, the prediction accuracy was further increased to 90% (24.35/27).

Conclusions

Smartphone apps such as SOLVD represent a useful way to monitor depressive symptoms in clinically depressed adolescents, and these apps correlate well with current gold-standard psychometric instruments. This is a first study of its kind that was conducted on the adolescent population, and it included inputs from both teens and their parents as observers. The results are preliminary because of the small sample size, and we plan to expand the study to a larger population.
Development of a Deep Learning Model for Dynamic Forecasting of Blood Glucose Level for Type 2 Diabetes Mellitus: Secondary Analysis of a Randomized Controlled Trial
Authors: Faruqui Syed Hasib Akhter , Du Yan , Meka Rajitha , Alaeddini Adel , Li Chengdong , Shirinkam Sara , Wang Jing
Published: September 2019

Background

Type 2 diabetes mellitus (T2DM) is a major public health burden. Self-management of diabetes including maintaining a healthy lifestyle is essential for glycemic control and to prevent diabetes complications. Mobile-based health data can play an important role in the forecasting of blood glucose levels for lifestyle management and control of T2DM.

Objective

The objective of this work was to dynamically forecast daily glucose levels in patients with T2DM based on their daily mobile health lifestyle data including diet, physical activity, weight, and glucose level from the day before.

Methods

We used data from 10 T2DM patients who were overweight or obese in a behavioral lifestyle intervention using mobile tools for daily monitoring of diet, physical activity, weight, and blood glucose over 6 months. We developed a deep learning model based on long short-term memory–based recurrent neural networks to forecast the next-day glucose levels in individual patients. The neural network used several layers of computational nodes to model how mobile health data (food intake including consumed calories, fat, and carbohydrates; exercise; and weight) were progressing from one day to another from noisy data.

Results

The model was validated based on a data set of 10 patients who had been monitored daily for over 6 months. The proposed deep learning model demonstrated considerable accuracy in predicting the next day glucose level based on Clark Error Grid and ±10% range of the actual values.

Conclusions

Using machine learning methodologies may leverage mobile health lifestyle data to develop effective individualized prediction plans for T2DM management. However, predicting future glucose levels is challenging as glucose level is determined by multiple factors. Future study with more rigorous study design is warranted to better predict future glucose levels for T2DM management.
Valoración de parques, árboles y plantas de ornato en Ciudad de México con datos de calidad de vida
Authors: Flores-Xolocotzi Ramiro
Published: September 2019

El objetivo de la investigación es realizar una valoración económica de dos variables: parques urbanos y árboles y plantas de ornato en Ciudad de México, con datos de la Encuesta de Percepción de Calidad de Vida, de 2012. Se emplearon modelos de calidad de vida, en función de variables sociodemográficas, servicios e ingreso mensual promedio del hogar. Según los resultados, con base en los parámetros estimados, la presencia de parques y árboles y plantas de ornato en el entorno es positiva para la calidad de vida de la población. La limitación del estudio es que los valores calculados pueden ser complementarios a las valoraciones por precios hedónicos, y para saber si es así se requiere investigar más sobre el mercado de vivienda; además de considerar problemas de endogeneidad en el ingreso, que pueden sobreestimar los valores monetarios. Se concluye que estos últimos son indicadores de la incidencia positiva de las dos variables valoradas en la calidad de vida de los citadinos.
EXPEDIENTE
Authors: Keys Eugênia Magna Broseguini
Published: September 2019

Expediente
Ensino Híbrido: aspectos teóricos e análise de duas experiências pedagógicas com Sala de Aula Invertida
Authors: Teixeira Barcelos Gilmara , Cristina Freitas Batista Silvia
Published: September 2019

De forma resumida, considera-se Ensino Híbrido como uma modalidade de ensino formal, na qual atividades presenciais e on-line são combinadas, de forma a contribuir para um ensino mais personalizado. No entanto, não há uma definição única para essa proposta, havendo variações inclusive em relação a que fatores podem ser combinados, de modo que a ação seja caracterizada como Ensino Híbrido. Nesse contexto, o presente trabalho tem por objetivo apresentar uma discussão sobre aspectos relacionados a essa modalidade de ensino. Tal discussão, que inclui considerações sobre a definição e sobre características dessa proposta, é respaldada por revisão bibliográfica e pela análise de duas experiências pedagógicas nas quais a Sala de Aula Invertida, uma forma de vivenciar o Ensino Híbrido, foi adotada. Dada a variedade de concepções e aspectos, considera-se fundamental que cada estudo relacionado ao tema Ensino Híbrido traga explicitamente a definição e a caracterização que o embasa.
Produção e Disponibilização de Recursos Digitais Educacionais na UFRGS – A Experiência do NAPEAD / SEAD
Authors: Trindade Perry Gabriela , Lima Ivana , De Araújo Carvalho Felipe , Ramos Caio , Santos Marlise
Published: September 2019

Neste artigo apresentamos o processo de produção de recursos educacionais do Napead - Núcleo de Produção Multimídia da UFRGS, vinculado à Sead (Secretaria de Educação a Distância) da UFRGS – Universidade Federal do Rio Grande do Sul, descrevendo as modalidades de serviços oferecidas, e como solicitá-las. Este relato serve como ponto de partida para contrastarmos a forma como gerenciamos nosso processo de produção com a que é relatada na literatura acadêmica, em especial a relacionada a vídeos e programas educacionais. Para atender a (crescente) demanda pelos nossos serviços, tivemos que encontrar uma forma de equacionar prazos e qualidade – e envolver professores e bolsistas em equipes interdisciplinares exigiria muito tempo de todas as partes. Também se considera que a diferença entre a experiência que temos e o que é relatado pela literatura deve-se ao fato de sermos um estúdio de produção, e não uma equipe envolvida com um projeto de pesquisa ou extensão – o que facilita o compartilhamento dos saberes pela equipe. Assumindo esta premissa, fica explicada a diferença entre as formas de produzir indicadas nos artigos consultados e a que estamos adotando atualmente.
The Ability of Supplying the Elliptical Items Omitted From a Written Text and its Impact on the Reading Comprehension of 4th Year Libyan University Students Studying EFL
Authors: Annajeh Abdussalam A.
Published: September 2019

This paper investigates the ability of supplying the elliptical items omitted from a written text and its impact on the reading comprehension of Libyan university students studying EFL. Ellipsis can be defined as the omission of one or more lexical items that are understood in the context, but which are required to make the sentence or utterance grammatically correct. An elliptical item could be nominal, verbal or clausal. 4th year English Department students from the English Department- Faculty of ArtsGharian in Al-Jabal Al-Gharbi University completed reading comprehension test. Seventy one out of a hundred and four students accepted to participate in the study. The test was modified to include many elliptical items and the students were asked to supply them. The results, which were statistically analyzed, suggested that the study participants were not able to supply the correct elliptical items and consequently had poor reading comprehension results. The mean marks achieved were only 33.8. This result may have many pedagogical implications.
Using Electronic Interaction as an Educational Support Tool in Higher Education: Studentsâ€™ Perception on using M-Learning and the Lecturersâ€™ Reflections
Authors: Rooyen Hannelie Van
Published: September 2019

Teaching and learning in higher education must be transformed to give support to the new generation of â€œdigital nativeâ€ students. Students depend on their mobile phones to do almost everything. The purpose of this research is to determine the perception of students on using mobile phones as an educational supporting tool and discusses higher education challenges and benefits of using electronic communication as an educational supporting tool. Most students use their mobile phones daily and they enjoy the technology that mobile phones offer them. The research was conducted at Vaal University of Technology (VUT) Ekurhuleni Campus. The findings of the research indicate that electronic communication will have a positive impact. Currently, more students have access to mobile phones than computers. Mobile phones can thus be considered an enabling technology in supporting learning and teaching. This research has provided a basis for VUT and other higher learning institutionsâ€™ academic leaders to start the discussion and the possibility of introducing the use of m-learning in adult education. With the increasing use of electronic communication, the traditional teaching approach and interaction between the lecturer and student(s) is changing and the adoption of friendly electronic communication has become more important.
Relationship between the properties of an interlayer formed by in situ Ti anodization and anaphoretically deposited hydroxyapatite
Authors: Pantovic-Pavlovic Marijana , Pavlovic Miroslav , Erakovic Sanja , Barudzija Tanja , Stevanovic Jasmina , Ignjatovic Nenad , Panic Vladimir
Published: September 2019

The optimization of the anodization process of Ti substrate for in situ synthesis of hydroxyapatite/titanium oxide composite coatings on titanium substrate was accomplished. The anodization was performed under 30, 60 and 90 V cell voltage, and the morphology of treated surface, as well as linear and surface roughness, were analysed by field emission-scanning electron microscopy, atomic force microscopy and roughness tester. It was shown by linear and surface roughness analyses that titanium anodized under 60 V has the highest roughness, whereas at 90 V the flattening of the surface occurs. As the highest surface roughness results emerged at 60 V, the novel process of composite anHAp/TiO2 coating synthesis, which comprises simultaneous processes of TiO2 formation and HAp deposition, as well as HAp impregnation within TiO2 surface layer, was performed at this voltage. Ti substrate surface was completely covered by composite coating, with no visible cracks. The adhesion quantified according to ASTM D3359-02 standard is considerably improved with respect to the coatings obtained by cathaphoretic processes, with no need of subsequent sintering.
Is It a Home Run? Measuring Relative Citation Rates in Accounting Research
Authors: Dechow Patricia M. , Sloan Richard G. , Zeng Jean (Jieyin)
Published: September 2019

SYNOPSIS

We propose a new set of citation metrics for evaluating the relative impact of scholarly research in accounting. Our metrics are based on current practices in bibliometrics and normalize citations by both field (accounting) and year of publication. We show that our normalized citation metrics dominate other commonly used metrics in accounting when predicting the long-term citation impact of recently published research. We conduct our analysis using citations from the Social Science Citation Index for the top six general interest accounting journals. More generally, our metrics can be readily constructed using any citation database and for any subfield of accounting. The metrics simply require the total citation counts for a benchmark set of papers published in the same calendar year. The use of these metrics should enable more informed performance evaluations of junior accounting researchers.
Consequences of Strategic Performance Measurement Systems: A Meta-Analytic Review
Authors: Endrikat Jan , Guenther Thomas W. , Titus Robert
Published: September 2019

About 25 years ago, Kaplan and Norton (1992) introduced the balanced scorecard (BSC) with the aim of remedying the inadequacies of traditional performance measurement approaches. From then on, the adoption of strategic performance measurement systems (SPMS) has steadily increased. While scholars have proposed and empirically tested several beneficial consequences of SPMS, the empirical results are not unequivocally clear and there is still a lack of consensus. This study builds on, complements, and expands current reviews by meta-analytically examining the associations among SPMS and 13 consequences of 67 primary studies, classified into three categories (i.e., people's behavior, organizational capabilities, and performance consequences). Overall, we find positive and significant mean correlations for all examined consequences. However, even after correcting for statistical artifacts, substantial heterogeneity remains. Therefore, we explore the heterogeneity by examining various theoretical and methodological moderators. Subgroup analysis reveals significant influences of (1) national culture (in terms of individualism and power distance), (2) presence or absence of links to the reward system, and (3) industry differences.
Komitmen Profesi dan Komitmen Organisasi sebagai Variabel Intervening dalam Hubungan antara Etika Kerja Islami dan Sikap terhadap Perubahan Organisasi
Authors: Sulistiyo Agung Budi
Published: September 2019

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Analisis Faktor Penentu Struktur Modal (Studi Empiris pada Emiten Syariah di Bursa Efek Jakarta 2001-2004)
Authors: Setyawan Hendri , Sutapa Sutapa
Published: September 2019

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ANALISIS KINERJA KEUANGAN PERUSAHAAN-PERUSAHAAN MANUFAKTUR YANG TERDAPAT DI BURSA EFEK JAKARTA SEBELUM DAN SESUDAH PEMBAYARAN DIVIDEN KAS
Authors: Shanti J.C.
Published: September 2019

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PENINGKATAN AKTIVITAS PEMBELAJARAN BAHASA INGGRIS MELALUI STRATEGI SAVI (SOMATIC, AUDITORY, VISUALIZATION, INTELLECTUALY) DENGAN MEDIA GAMBAR TERHADAP SISWA KELAS IV SD NEGERI 1 SONOREJO BLORA
Authors: Kaltsum Honest Ummi , Wijayanti Noviana
Published: September 2019

This research aims to enhance the activity of learning English, and motivated by the low learning motivation of students at the fourth grade SDN 1 Sonorejo Blora (24 students). The method of data collection is in the form of tests, observation, documentation. Beside, this research applies interactive analysis to analyze the data collected. The results of this research show that there is an enhancement in the 1. Asking activity: first cycle 33.3%, 41.6% the second cycle, the third cycle of 50%; 2. Expressing their ideas 16.6% first cycle, the second cycle 25%, 33.3% the third cycle; 3. Answering the questions: 25% the first cycle, the second cycle 33.3%, 41.6% the third cycle; 4. Discussion activity: the first cycle 33.3%, the second cycle 50%, 66.6% the third cycle; 5. Doing the tasks given: first cycle 75%, the second cycle 83.3%, 91.6% third cycle.
Pengembangan Kompetensi Pedagogik Menuju Sekolah Bermutu
Authors: Khusnan Khusnan , Sutrisno Budi
Published: September 2019

The purpose of this study was to determine the development paedagogical com petence to school quality at SDN Banaran 1 described in two subfocuses, namely: 1) Assess the characteristics of the development of curriculum related to the subject matter teachers, 2) Assessing the educational characteristics of the learning organization. Data were col lected through interviews (indepth interviews), observation and document. Data analysis was carried out in the field before and during the field with Miles and Hubberman models interactively through a process of data reduction, data display and conclusion drawing. Results and discussion concluded that the profiles of development paedagogical competence toward school quality at SDN Banaran 1 is the development of theories that exist in previous studies. The development of the theory can be aware of the characteristics of development paedagogical competence performed SDN Banaran 1 as: placing the school commit tee and education experts as partners, to establish communication with parents / guardians, provide training to teachers in selecting appropriate learning strategies and to develop learning materials, as well as reducing the burden of additional teachers. Moreover, in implementing educational learning, SDN Banaran 1 provides enrichment and improvement as well as the addition of the grade six class hours in particular, carry out learning inter action optimally position the child as a subject of learning, contextual learning materials, learning through small group and the maximum using facility to stimulate student learning.
Pengaruh Strategi Pembelajaran Klarifikasi Nilai Dan Locus of Control Terhadap Kemampuan Berpendapat Mahasiswa
Authors: Sukisno Sukisno
Published: September 2019

This study aimed to examine the effect of VCT instructional strategies (pair group and small groups of 4-7 students) and student’s locus of control on learning outcomes in civics courses. The aim of this study was to determine the main effects and the interaction effect of treatment and moderator variables on Civics Education learning outcomes. This quasi-experimental study used a factorial design with posttest non-equivalent control group design. Subjects of this study were the second semester students, Economic department, 2012-2013 academic year. The subjects were 74 students, consisting of 36 students from class A for the experimental class and 38 students from class B as a control class. The results of this study indicates that 1) there is significant differences of argument ability of the students in Civics between the groups of students studying with the pair group VCT learning strategy and those with VCT small groups of 4-7 students, 2) the argument ability of Civics Education learning students in Civics course, between groups of students with internal locus of control and those with external locus of control, significantly different, and 3) instructional strategies and locus of control shows the interaction effect on arguing ability in Civics.
Prevalence, Antimicrobial Resistance, and Molecular Typing of Thermophilic Campylobacter Spp. in a Greek Poultry Slaughterhouse
Authors: Sakaridis Ioannis , Papadopoulos Theofilos , Boukouvala Evridiki , Ekateriniadou Loukia , Samouris Georgios , Zdragas Antonios
Published: September 2019

Campylobacter species are one of the leading causes of foodborne disease. Poultry is a major reservoir and source of its transmission to humans. The aim of this study was to estimate the prevalence and antimicrobial resistance of Campylobacter spp. isolated from chicken carcasses, the environment, and processing equipment of a poultry slaughterhouse in Greece, to identify the dominant Campylobacter species and to determine if there are clonal relationships among the isolates. Fifty poultry samples and 25 environmental samples were examined using microbial cultures and PCR. Forty-nine of 50 poultry samples (98%) were found to be positive for Campylobacter spp. The environment of the slaughterhouse was also found to be significantly contaminated with Campylobacter spp. Thirty-seven isolates were found to be susceptible to all antimicrobials tested (56.1%) and 29 isolates showed resistance to at least two of the antimicrobials tested (43.9%). We observed 24 different PFGE-types among the 53 isolates with 14 of them isolated only once, while five PFGE-types were represented by two isolates. The remaining 29 isolates were represented by five PFGE-types each consisting of three to 12 isolates. Regarding the relationship of the PFGE types and corresponding resistance profiles, all strains of each PFGE-type shared the same antimicrobial resistance profile. This study reports evidence for Campylobacter spp. cross-contamination among broiler carcasses in a Greek slaughterhouse.
A Case of Lymphocytic Leukemia in a Bearded Dragon (Pogona vitticeps) and a Review of Literature
Authors: Gavazza Alessandra , Galosi Livio , Croce Veronica , Croce Amerio , Genovese Carla , Romano Paolo , Cerquetella Matteo , Rossi Giacomo
Published: September 2019

The present paper reports the case of a 3 years old, female Bearded Dragon (Pogona vitticeps) presenting lethargy, anorexia, weight loss, and anemia and marked leukocytosis at CBC. The majority of leukocytes were lymphocytic/lymphoblastic cells (97%). Immunocytochemical staining of blood smears marked for CD3 (neg) and CD79a (pos) suggested immunophenotype B. The patient died after one month from diagnosis. Histology evidenced lymphoid infiltration in the heart, spleen, liver, kidneys and gut. In addition, in the bone marrow a massive infiltration of lymphoid cells confirmed the diagnosis of leukemia. Immunohistochemistry confirmed the CD79a positivity of a large part of infiltrating lymphoid cells indicating a B cells immunophenotype of the neoplastic population. The presence of lymphocytosis and multiorgan infiltration supported the diagnosis of lymphocytic leukemia. Finally, a revision of the literature has also been made.
The effects of extracurricular physical education classes on gross motor development in primary school children – pilot study
Authors: Skowroński Waldemar , Skowrońska Marianna , Rutkowska Izabela , Bednarczuk Grzegorz , Kaźmierska-Kowalewska Kalina Maria , Marszałek Jolanta
Published: September 2019

Study aim: The aim of the study was to investigate the changes in gross motor skills in children participating and not participating in a project of extracurricular physical education classes in primary schools called “From fun to sport”.

Material and methods: Thirty-one children in the first grade of primary school participated in the study (16 boys and 15 girls). A pedagogical quasi-experiment was applied. Children from the experimental group participated in an additional 45-minute lesson. To assess gross motor skills the TGMD-2 (Test of Gross Motor Development-2) was used.

Results: Statistically significant differences were observed in the level of gross motor skills between children attending extracurricular physical education classes and those who did not participate in such activities (GMDQ: Δ boys = 11.86, p = 0.032; Δ girls = 13.1, p = 0.036).

Conclusion: The experiment revealed large effects of additional activities of the project on increase of children’s motor skills level. Additional time should be included in physical education for the development of gross motor skills in physical education classes at the initial stage of school education.
Frustrating Absences
Authors: Abath André J.
Published: September 2019

Experiences of absence are common in everyday life, but have received little philosophical attention until recently, when two positions regarding the nature of such experiences surfaced in the literature. According to the Perceptual View, experiences of absence are perceptual in nature. This is denied by the Surprise-Based View, according to which experiences of absence belong together with cases of surprise. In this paper, I show that there is a kind of experience of absence—which I call frustrating absences—that has been overlooked by the Perceptual View and by the Surprise Based-View and that cannot be adequately explained by them. I offer an alternative account to deal with frustrating absences, one according to which experiencing frustrating absences is a matter of subjects having desires for something to be present frustrated by the world. Finally, I argue that there may well be different kinds of experiences of absence.
Gender and Absolute ‘I’ of a Person: Scope of Contraposition and New Contexts of Identity
Authors: Zharkimbayeva D. , Imanzhussip R. , Mukatayeva A. , Zhumaxanova M. , Bolyssova K.
Published: September 2019

The aim of the study is to investigate gender and absolute ‘I’ of a person as scope of contraposition and new contexts of identity. The methodological basis of the study of the philosophy of gender is the idea of the Absolute ‘I’ of a person, scope of contraposition of gender and sex, new contexts of gender identification. Person is inseparable from his essence, which determines his gender. As a result, identity is an open system, therefore the process of changing the identity of both men and women is an interdependent change of mindsets complementing and enriching each other and the world around. In conclusion, the male, which is obviously not changeable enough, can be ultimately completed to the female principle. People are attracted to men who prone to dialogue and mercy. But the feminine principle, which constitutes all the beauty in a person, is instant, and cannot have rigidity, totalitarian firm determination, in a word, those qualities that should have a long-term perspective.