bluuebunny/crossref_metadata_2025 huggingface dataset:
CONFRONTING UNCERTAINTY AND AMBIGUITY: THE POWER OF ORGANIZATIONAL IMMUNE SYSTEMS (AN EMPIRICAL STUDY ON MIDDLE EAST TOURISM COMPANIES)
Authors:   Faculty of Business, King Khalid University, Abha, Saudi Arabia, HAASAN Fatimah ,   Faculty of Commerce, Suez University, Suez, Egypt, HADDADI Essa ,   Faculty of Business, King Khalid University, Abha, Saudi Arabia
Published: June 2024

The contemporary tourism work environment faces several persistent challenges that limit its growth and competitiveness. This study examines the influence of organizational immune systems by focusing on three dimensions (organizational learning, organizational memory, and organizational DNA) on the ability of tourism companies in the Middle East to confront uncertainty and ambiguity in the tourism work environment. This study used a questionnaire and structural equation modeling (PLS-SEM) to analyze data from 438 employees in 68 tourism companies across nine countries. A comprehensive analysis of several important reports from international tourism organizations and related organizations was conducted for the sector from 2019 to the first quarter of 2024 to identify opportunities and threats. The discussions clarified the importance and impact of the dimensions of organizational immunity and their impact on enhancing the ability of tourism companies to face uncertainty, the challenges and rapid changes they face. The study also provides insights in to potential opportunities and threats for companies to capitalize on. By submitting a proposal, a practical strategic development model is developed as a major contribution to this study.
DIGITAL LEADERSHIP AND CREATIVE PERFORMANCE IN TOURISM AND HOTEL ENTERPRISES: LEVERAGING STRATEGIC AGILITY AND ORGANIZATIONAL LEARNING CULTURE
Authors:   Department of Economics of Investment and Business Management, Faculty of Business Economics, Alnahrain University, Baghdad, Iraq, JASIM Tarik Ali , KHAIRY Hazem Ahmed ,   Hotel Management Department, Faculty of Tourism and Hotels, University of Sadat City, Sadat City, Egypt, FAYYAD Sameh ,   Hotel Management Department, Faculty of Tourism and Hotels, University, Giza, Egypt; Hotel Studies Department, Faculty of Tourism and Hotels, Suez Canal University, Ismailia, Egypt, AL-ROMEEDY Bassam Samir ,   Tourism Studies Department, Faculty of Tourism and Hotels, University of Sadat City, Sadat City, Egypt
Published: June 2024

The aim of this study is to explore the effect of digital leadership (DL) on creative performance (CP) by investigating the mediating roles of strategic agility (SA) and organizational learning culture (OLC) in tourism and hospitality industry. The study analyzed 320 responses from middle-level management at five-star hotels and category-A travel agencies in Egypt using the PLS-SEM technique and WarpPLS statistical software 7.0. Findings reveal that digital leadership positively affects creative performance, strategic agility, and organizational learning culture. In addition, CP is positively affected by SA and OLC. Moreover, findings confirm the mediation effects of strategic agility and organizational learning culture in the DL→CP relationship. The study provides practical insights for tourism and hospitality enterprises using Dynamic Capabilities Theory to enhance performance and agility in the digital age.
VOLCANO TOURISM: HOW DO DESTINATION AWARENESS AND CREDIBILITY DEVELOP VISIT INTENTION FOR MOUNT BROMO IN INDONESIA
Authors:   Faculty of Economics, Universitas Negeri, Jakarta, Indonesia, SUHUD Usep , ALLAN Mamoon ,   Faculty of Archaeology and Tourism, University of Jordan, Amman, Jordan, HOO Wong Chee ,   Faculty of Business and Communications, INTI International University, Nilai, Malaysia
Published: June 2024

This study investigates the impact of destination awareness, credibility, reputation, and association on visit intention. The study was conducted at Mount Bromo, in Indonesia’s East Java Province, which has become a popular destination for domestic and international tourists. The study involved 227 participants selected through the convenience sampling method, and the collected data were analysed using exploratory and confirmatory factor analysis and structural equation models. The study found that destination awareness and credibility significantly influenced destination reputation and association, which, in turn, had a significant impact on visiting intentions. These research findings are essential in advancing volcano tourism studies and provide a deeper understanding of the factors influencing tourist intention to visit such destinations. The implications of these research findings can guide tourism industry practitioners and decision -makers in developing more effective marketing strategies, and this study contributes significantly to volcano tourism literature.
HÉRNIA INTERNA ATRAVÉS DO FORAME DE WINSLOW: RELATO DE CASO
Authors:   Universidade Estadual de Maringá, Rodrigues Fontes Carlos Edmundo , Jordana de-Mello Bruna , Shehadeh Imad , Rossato Chrun Lucas
Published: June 2024

Introdução:A hérnia em forame de Winslow é uma condição extremamente rara frequentemente associada a sintomas gastrointestinais, como obstrução intestinal e dor abdominal difusa. Apesar de rara, quando ocorre, devido atraso no diagnóstico e tratamento, pode resultar em complicações severas e altas taxas de mortalidade. Na maioria dos casos, os sintomas são inespecíficos e variam de acordo com o conteúdo herniado e grau de evolução da afecção. O diagnóstico pré-operatório é infrequente. Relato de caso: Apresentamos um caso de paciente, 61 anos, sexo feminino, admitida com diagnóstico sindrômico de abdome agudo obstrutivo. O exame de imagem realizado na ocasião direcionou a necessidade de laparotomia exploradora, concluindo, no intra-operatório, o diagnóstico de hérnia interna em forame de Winslow. Conclusão: o diagnóstico da hérnia interna de Winslow é raro e sua apresentação inespecífica torna o diagnóstico um desafio para os cirurgiões. Palavras-chave: Laparotomia. Hérnia Interna. Abdome Agudo
HÉRNIA PULMONAR TRAUMÁTICA APÓS FRATURA DE ESTERNO E ARCOS COSTAIS À DIREITA: RELATO DE CASO
Authors:   Faculdade de Medicina de São José do Rio Preto, Cardoso da Silva Ana Caroline , Ignacio Cunha Laura , Silvério da Paixão Filh Adriano o , Yumi Takaoka Laís , de Almeida Marques Paula , Espada Paulo César ,   Hospital de Base de São José do Rio Preto
Published: June 2024

Introdução: O presente estudo tem por finalidade realizar um relato de caso sobre hérnia pulmonar traumática, como forma de ampliar o conhecimento sobre o tema entre profissionais de saúde, visto sua baixa incidência e controvérsias sobre manejo terapêutico. Relato de caso: Paciente de 43 anos, condutor de motocicleta, com trauma versus veículo, ocasionando fratura de esterno e arcos costais com herniação pulmonar imediata e necessidade de manejo cirúrgico para correção do defeito de parede. Conclusão: A terapêutica adequada para o caso é controversa, porém, há consenso na necessidade de maiores estudos e atualizações a fim de alcançar o diagnóstico e tratamento precoces, com melhora na sobrevida do paciente. Palavras-chave: Traumatismos Torácicos. Tórax Fundido. Fraturas das Costelas. Fixação Interna de Fraturas.
CARCINOMA PAPILÍFERO SURGINDO EM STRUMA OVARII: RELATO DE CASO
Authors:   Faculdades Pequeno Príncipe, Wolff Barretto Julia , Costa Linhares Júlia , Bayer Battistotti Renata , Massumi Kozonoe Milena , Hamad Mehanna Samya ,   Hospital Erasto Gaertner
Published: June 2024

Introdução: Struma ovarii é um tipo raro de tumor de ovário com comportamento usualmente benigno; apesar disto, uma minoria pode sofrer malignização, sendo que quando isto ocorre, o mais comum é que se dê na forma de carcinoma papilífero de tireoide. O curso clínico costuma ser insidioso, e ao exame histopatológico, observa-se tecido tireoidiano maduro associado à coexistência de carcinoma papilífero de tireoide com características nucleares típicas. Relato de caso: O presente relato descreve caso de struma ovarii maligno em paciente do sexo feminino de 77 anos, com quadro clínico de distensão e dor abdominal inespecífica, com aumento dos níveis sérios de CA125 e presença de nódulos benignos na tireoide. Conclusão: A doença aqui retratada afeta mais mulheres em idade fértil, podendo se apresentar de forma assintomática ou de forma inespecífica. Para o correto diagnóstico, além da exclusão da possibilidade de neoplasia primária de tireoide com metástase para ovário, é necessário exame anatomopatológico que demonstra o padrão típico de carcinoma papilífero de tireoide. Palavras-chave: Neoplasias Ovarianas. Estruma Ovariano. Carcinoma Papilífero da Tireoide.
CUTANEOUS METASTASIS AND RENAL CELL CARCINOMA: CHALLENGES AND PERSPECTIVES
Authors:   Universidade Potiguar, Barbalho de Melo Luis Eduardo , Batista do Rêgo Marina Mayara , Costa de Carvalho Sofia , Lima Barbalho de Mello Maria Eduarda , Pires Cavalcante Giovanna , Cidrão Castelo Ribeiro Duarte Maria Raquel , Loyola da Silva Thais Cristina , Araújo Filho Irami
Published: June 2024

Introdução: As metástases cutâneas originadas do carcinoma de células renais (CCR) são ocorrências incomuns que, frequentemente, sinalizam estágios avançados e agressivos da doença. Relato de caso: Neste relato de caso, explorou-se a apresentação singular de um paciente que teve as metástases cutâneas como sua primeira manifestação do CCR. As lesões tumorais na pele, notáveis por seu caráter vascular, subcutâneo, múltiplas e de crescimento acelerado, especialmente no couro cabeludo e na face, levantaram a suspeita de metástases secundárias de origem renal. Além do caso clínico em destaque, os autores conduziram uma revisão detalhada da literatura sobre o tema. Conclusão: O presente estudo facilita a compreensão das metástases cutâneas do CCR, uma vez que, em geral, quando o envolvimento cutâneo é evidenciado, a doença já está disseminada, com prognóstico reservado. Portanto, um exame meticuloso da pele desempenha um papel crucial na formulação do diagnóstico e na determinação do plano de tratamento nesse cenário clínico complexo. Palavras-chave: Carcinoma de Células Renais. Metástase Neoplásica. Neoplasias Primárias Desconhecidas. Pele.
HÉRNIA DE AMYAND COM APENDICITE AGUDA: UM RELATO DE TRATAMENTO CIRÚRGICO COM USO DE TELA
Authors:   Santa Casa de Franca, Malaquias Vidal Heloísa , Alkmin Lopes de Lima Roberta Denise , Silva Almeida Gustavo Henrique , Carvalho da Silva Júnior Ronald , Monteiro Piassa João Pedro , Poli Leonel Felipe
Published: June 2024

Introdução: devido à raridade da hérnia de Amyand, seu manejo cirúrgico pode representar um desafio para os cirurgiões gerais, já que a maioria é diagnosticada no intra-operatório. A recomendação clássica na literatura para correção do defeito da parede posterior diante de uma hérnia de Amyand com apendicite aguda é realizar apendicectomia e herniorrafia. Contudo, atualmente existe uma dificuldade em padronizar a técnica cirúrgica, ficando geralmente a critério do cirurgião. Relato de caso: paciente do sexo masculino, 63 anos, diagnosticado no pré-operatório com hérnia de Amyand complicada com apendicite aguda perfurada, cujo tratamento cirúrgico teve sucesso com uso de tela. Conclusão: o reparo com uso de tela nos casos em que há apendicite aguda restrita ao saco herniário sem sepse intraperitoneal demonstrou ser uma abordagem viável e segura. Em nosso relato, foi observada melhora clínica completa do quadro infeccioso, além da ausência de infecção de sítio cirúrgico e menor risco de recidiva da hérnia. Palavras-chave:Apendicite. Hérnia Inguinal. Abdome Agudo. Apendicectomia. Herniorrafia.
PIELONEFRITE XANTOGRANULOMATOSA COM PIONEFROSE VOLUMOSA EM UMA PRIMIGESTA: MANEJO CLÍNICO-CIRÚRGICO
Authors:   Universidade Federal do Paraná, Biasi da Cunha Fernanda , Lopes Lange Paulo Afonso , Rios Rodriguez Juan Eduardo , Souza Smanioto Caio Cesar , Mitsue Kishi Nathália , Cavalheiro Cavalli Alexandre
Published: June 2024

Introdução: A Pielonefrite xantogranulomatosa (PXG) é uma infecção renal crônica de baixa prevalência e alta morbidade, com apenas oito casos conhecidos relatados em gestantes. O objetivo deste artigo é descrever o caso de uma gestante no terceiro trimestre com PXG, discutindo as opções para seu manejo. Relato de caso: Primigesta de 29 anos de idade, 31 semanas de idade gestacional, com histórico de infecções do trato urinário de repetição e nefrolitíase buscou atendimento por dor lombar. Os exames físico e laboratorial eram indicativos de pielonefrite, com exames de imagem sugestivos de PXG e pionefrose volumosa à esquerda. Foi realizado manejo inicial com antibioticoterapia e conduta expectante até o parto. No puerpério, realizou-se implante de cateter duplo J e nefrostomia, com posterior nefrectomia videolaparoscópica, sem complicações maternofetais. Conclusão: Destaca-se no trabalho a efetividade do tratamento: manejo clínico até o parto- com boa resposta à antibiotiterapia, seguido de drenagem por nefrostomia que possibilitou a nefrectomia pós-parto – sem risco fetal e com menor dificuldade técnica. Ainda, foi possível remover o órgão pela incisão da cesárea. Este relato reforça que a antibioticoterapia aliada a nefrostomia prévia parece ser uma abordagem eficaz, que facilita o tratamento definitivo e diminui as taxas de complicações. Palavras-chave: Pielonefrite Xantogranulomatosa. Pionefrose. Gravidez.
Explicar más para comprender mejor: neurociencias y narratividad
Authors: Delpech María Beatriz
Published: June 2024

En el diálogo entre Paul Ricoeur y Jean-Pierre Changeux, publicado como La naturaleza y la norma (2001), se discute la relación entre la narrativa, la neurociencia y la filosofía. Ricoeur defiende un dualismo semántico que separa los discursos sobre el cerebro y el cuerpo propio, mientras que Changeux busca una intersección entre ambos. Aunque aún no se haya logrado una conexión definitiva entre el conocimiento narrativo y los procesos neuronales, la modelización explicativa enriquece nuestra comprensión del fenómeno narrativo. Ricoeur sostiene que la narrativa es fundamental para la formación de la identidad personal, argumentando que esta se construye a través de historias sobre uno mismo. Sin embargo, reconoce que estas historias no son totalmente controladas por el individuo, sino que están influenciadas por diversos factores. Haremos un breve repaso de los pilares de la teoría narrativa ricoeuriana para poner de manifiesto que se corresponden con los intereses de las investigaciones actuales en el campo de la neurociencia. Asimismo, recorreremos ciertos trabajos dedicados a la teoría narrativa desde la neurociencia de la última década para actualizar el estado de la cuestión y poder renovar el diálogo entre hermenéutica y “neuro-narrativa”. Mostraremos que la adopción por parte de la neurobiología del vocabulario, así como de los intereses de ciertos humanismos filosóficos y literarios, por un lado redimensiona las expectativas de las neurociencias y, por otro lado, tienden hacia la interdisciplinariedad. La narratología y la neurociencia encuentran puntos de encuentro en la cognición narrativa, que emerge de procesos neurobiológicos y es incompatible con una visión estática e inflexible del ser humano. La conexión entre el plano neurofisiológico y el plano filosófico permite una interpretación más amplia y profunda de la experiencia humana y la formación de la identidad personal.
En resumen, el diálogo entre la narrativa, la neurociencia y la filosofía revela la complejidad del ser humano y su identidad, destacando la importancia de una perspectiva interdisciplinaria para abordar estos temas. Aunque aún existen desafíos para establecer una conexión definitiva entre el conocimiento narrativo y los procesos neuronales, se han identificado vínculos que enriquecen nuestra comprensión del fenómeno narrativo y la formación de la identidad personal. En conclusión, sugeriremos que no tiene sentido en este contexto actual, más de veinte años después del diálogo entre Ricoeur y Changeux, sostener un dualismo de ningún tipo.
Multiplier Effect Pengembangan Wisata Pasar Papringan Ngadiprono Desa Ngadimulyo Kecamatan Kedu terhadap Kondisi Ekonomi Masyarakat
Authors: Sovi Puji Utami  , Lorentino Togar Laut  , Jalu Aji Prakoso
Published: June 2024

Pasar Papringan Ngadiprono yang berada di Dusun Ngadiprono, Desa Ngadimulyo, Kecamatan Kedu, Kabupaten Temanggung turut berkontribusi terhadap kesejahteraan masyarakat. Penelitian ini bertujuan untuk mengetahui potensi, dampak langsung, dampak tidak langsung dan dampak induce wisata Pasar Papringan Ngadiprono terhadap masyarakat sekitar. Data yang digunakan merupakan data primer berupa kuesioner dengan teknik pengambilan sampel menggunakan rumus slovin dan diambil sampel kelompok wisatawan terdiri dari responden wisatawan, kelompok pertama terdiri dari responden penjual kuliner, kelompok kedua terdiri dari responden pengelola, responden tenaga kerja lokal (kebersihan) yang, responden tenaga kerja lokal (Penukaran uang bambu), responden tenaga kerja lokal (tim asah-asah), dan responden penjual kemasan dan kerajinan, dan kelompok ketiga terdiri dari responden petani, responden masyarakat sekitar, responden tukang parkir, responden penginapan, dan responden pemilik toilet. Hasil analisis deskriptif menunjukkan bahwa potensi pariwisata Pasar Papringan Ngadiprono yang menarik dengan beragam kuliner tradisionalnya, tempat pasar yang berada di bawah rumpunan bambu dan sangat asri, ketersediaan fasilitas yang memadai dan menarik namun kondisinya masih kurang, ketersediaan moda transportasi yang cukup dan kualitas jalan yang sedang. Berdasarkan hasil perhitungan multiplier effect, nilai Ratio Income Multiplier tipe I di kawasan wisata Pasar Papringan Ngadiprono sebesar 1.57, dan berdasarkan hasil perhitungan Multiplier Effect, nilai Ratio Income Multiplier tipe II di kawasan wisata Pasar Papringan Ngadiprono sebesar 2.19.
Kata kunci: Multiplier Effect, Dampak Ekonomi, Wisata
Persepsi Wisatawan Terhadap Dampak Pengembangan Pariwisata Berkelanjutan di Desa Wisata Nglanggeran, Kabupaten Gunungkidul
Authors: Wisnu Pramudya  , Syahrul Hidayat
Published: June 2024

Program Sertifikasi Desa Wisata Berkelanjutan merupakan salah satu upaya pemerintah Indonesia dalam mengakselerasi pembangunan pariwisata berkelanjutan pada tingkat mikro. Salah satu desa wisata yang sudah berhasil menerima sertifikasi tersebut adalah Desa Wisata Nglanggeran yang berlokasi di Kabupaten Gunungkidul, Provinsi DIY. Berbagai penelitian telah menunjukkan secara empiris, khususnya dari sudut pandang masyarakat lokal, bahwa upaya pembangunan pariwisata berkelanjutan dapat meminimalisir dampak negatif pariwisata dan memberikan manfaat dalam berbagai aspek kehidupan masyarakat lokal. Meskipun demikian, penelitian yang membahas persepsi wisatawan terhadap dampak pengembangan pariwisata berkelanjutan masih relatif sedikit, khususnya pada konteks destinasi berskala mikro seperti desa wisata sehingga terdapat research gap dalam kajian pariwisata berkelanjutan. Persepsi wisatawan dapat membentuk citra suatu destinasi baik secara positif dan negatif sehingga menjadi penting untuk diketahui. Penelitian ini bertujuan untuk mengisi adanya gap tersebut dengan melakukan kajian terhadap dampak pembangunan desa wisata berkelanjutan di Nglanggeran dari perspektif wisatawan. Pengumpulan data dilakukan dengan cara menyebar survei berbasis kuesioner. Data yang sudah dikumpulkan kemudian dianalisis secara deskriptif dengan menggunakan statistik. Hasil penelitian menunjukkan bahwa wisatawan menganggap pengembangan Desa Wisata Nglanggeran sudah sesuai dengan prinsip pembangunan pariwisata berkelanjutan. Dengan demikian, keberadaan desa wisata berdampak positif terhadap keberlanjutan aspek lingkungan, kelembagaan, sosial budaya dan ekonomi. Pemerintah daerah dan pengelola desa wisata diharapkan dapat terus menjaga kolaborasi yang sudah dilakukan dengan baik selama ini dan secara berkelanjutan melakukan monitor terhadap pengelolaan desa wisata.
Kata kunci: Pembangunan berkelanjutan, Pariwisata berkelanjutan, Dampak pariwisata, Perspektif wisatawan, Desa wisata
Los ayudantes de cátedra en Argentina tienen mayores intenciones de migrar al extranjero como médicos que otros estudiantes de Medicina
Authors: Pereyra Victoria , Díaz Julio César , Casin Fijtman Gustavo , Zerega Pablo Juan , Politi Maria Teresa
Published: June 2024

Introducción: La fuga de cerebros de médicos de países de ingresos medianos- bajos a países de ingresos altos es un fenómeno creciente que contribuye a las desigualdades mundiales en salud. Las estrategias de retención son difíciles de implementar localmente y de dirigir específicamente a la población en riesgo de migrar. Hipotetizamos que los estudiantes de Medicina que son ayudantes tienen mayores intenciones de migrar para ejercer la Medicina en el extranjero.
Métodos: Estudiantes de Medicina de Argentina fueron invitados a una encuesta online de 22 preguntas de opción múltiple basada en la encuesta de la Red LIRHUS, previamente utilizada en América Latina.
Resultados: Se enrolaron 2.301 estudiantes de Medicina. La mayoría eran jóvenes (23 [20-25] años), solteras (90%) y mujeres (79%). La mayoría estudiaba en universidades públicas (87%). La intención de migrar para ejercer la Medicina en el extranjero fue más frecuente entre los ayudantes (36% vs 31%; χ2 = 4,4982; p = 0,0339). Después de ajustar por sexo y edad, ser ayudante se asoció con la intención de migrar para ejercer la Medicina (OR = 1,26; IC 95% 1,02 - 1,55; p = 0,002).
Conclusiones: Los ayudantes argentinos tienen mayor riesgo de migrar para ejercer la Medicina en el exterior. Dado su alto perfil académico, se trata de recursos humanos valiosos formados con la financiación pública de un país de ingresos medianos-bajos, cuya pérdida puede contribuir a las desigualdades en salud. Es un subgrupo fácilmente identificable y accesible hacia el que se pueden dirigir políticas de retención locales.
Plant species in recreational spaces of Initial Education Establishments of Bahía Blanca District (Buenos Aires, Argentina): Analysis of its diversity and educational role.
Authors: Pérez Cuadra Vanesa , Verolo Magali , Cambi Vivina
Published: June 2024

Introduction and aims: The plant species grown in Educational Establishments are diverse, reflecting the customs of the local population. Their presence couldcontribute to the revaluation of local flora, acting as pedagogical triggers and fulfilling an ornamental function simultaneously. The objectives of this study are to inventory the plant species in recreational spaces of the kindergartens of the Bahía Blanca District and to collect information related to the presence of these species, as well as the general knowledge that managers/teachers have about them.M&M: A floristic census was carried out in recreational spaces of 85 public and private kindergartens. Directors/teachers were surveyed/interviewed to recordcomplementary information about the species and their role in the institution.Results: Two hundred seventy-two species belonging to 86 botanical families were identified. 88% were found to be exotic, and 12% were native, with 1.45% being endemic to Argentina. 100% of all kindergartens that present plants have exotic species, 43% 43% native species and 10% endemic species. The teachers recognize a need for knowledge of the botanical environment and mention aninterest in training on the subject.Conclusions: The diversity of plant species in the recreational spaces of kindergartens is high, most of them being exotic. It is important to plan plant species in these institutions so that they can be used as teaching resources.
Differential histopathological response of pepper (Solanaceae) cultivars to Nacobbus celatus (Nematoda) populations
Authors: Cabrera Verónica A. , Doucet Marcelo E. , Lax Paola
Published: June 2024

Background and aims: The false-root knot nematode (Nacobbus spp.) comprises polyphagous species, with pepper (Capsicum annuum) being one of the most affected crops. Due to the lack of resistant pepper genotypes, we compared the responses of different commercial cultivars to identify possible plant defence mechanisms against N. celatus.
M&M: Nematodes from Río Cuarto (Córdoba Province) and Lisandro Olmos (Buenos Aires Province) were inoculated on pepper cultivars: California Wonder (control), Fyuco INTA, Yatasto, and Fenomeno RZ. Plants were grown under a greenhouse and galls were analysed by histopathological techniques.
Results: The roots of the commercial cultivars showed the typical morpho-anatomical alterations induced by N. celatus: gall formation, hyperplasia reactions, development of syncytia in the central cylinder and disorganisation of vascular tissues. Syncytial cells in contact with females of nematodes from Lisandro Olmos showed a defence reaction by Fyuco INTA, whereas feeding sites in Fenomeno RZ did not denote high metabolic activity in nematodes of both origins.
Conclusions: The different responses observed between populations and/or hosts demonstrate the importance of considering nematodes from different geographical origins when testing plant material for tolerance and/or resistance to N. celatus. Studies of this nature are necessary since they facilitate a more in-depth understanding of the parasite-plant interaction.
Exploring Programmed Cell Death-Related Biomarkers and Disease Therapy Strategy in Nasopharyngeal Carcinoma Using Transcriptomics
Authors: Yan Jiangyu , Wu Linrong , Zheng Mengmeng , Pan Fangfang
Published: June 2024

Background: Uncontrolled cellular proliferation may result in the progression of diseases such as cancer that promote organism death. Programmed cell death (PCD) is an important mechanism that ensures the quality and quantity of cells, which could be developed as a potential biomarker for disease diagnosis and treatment. Methods: RNA-seq data and clinical information of nasopharyngeal carcinoma (NPC) patients were downloaded from the Gene Expression Omnibus (GEO), and 1548 PCD-related genes were collected. We used the “limma” package to analyze differentially expressed genes (DEGs). The STRING database was used for protein interaction analysis, and the least absolute shrinkage and selection operator (Lasso) and support vector machines (SVMs) regression analyses were used to identify biomarkers. Then, the timeROC package was used for classifier efficiency assessment, and the “CIBERSORT” package was used for immune infiltration analysis. Wound healing and transwell migration assay were performed to evaluate migration and invasion. Results: We identified 800 DEGs between our control and NPC patient groups, in which 59 genes appeared to be PCD-related DEGs, with their function closely associated with NPC progression, including activation of the PI3K–Akt, TGF-β, and IL-17 signaling pathways. Furthermore, based on the STRING database, Cytoscape and six algorithms were employed to screen 16 important genes (GAPDH, FN1, IFNG, PTGS2, CXCL1, MYC, MUC1, LTF, S100A8, CAV1, CDK4, EZH2, AURKA, IL33, S100A9, and MIF). Subsequently, two reliably characterized biomarkers, FN1 and MUC1, were obtained from the Lasso and SVM analyses. The Receiver operating characteristic (ROC) curves showed that both biomarkers had area under the curve (AUC) values higher than 0.9. Meanwhile, the enrichment analysis showed that in NPC patients, the FN1 and MUC1 expression levels correlated with programmed cell death-related pathways. The enrichment analysis and cellular experimental results indicated that FN1 and MUC1 were overexpressed in NPC cells and associated with programmed cell death-related pathways. Importantly, FN1 and MUC1 severely affected the ability of NPC cells to migrate, invade, and undergo apoptosis. Finally, medroxyprogesterone acetate and 8-Bromo-cAMP acted as drug molecules for the docking of FN1 and MUC1 molecules, respectively, and had binding capacities of –9.17 and –7.27 kcal/mol, respectively. Conclusion: We examined the PCD-related phenotypes and screened FN1 and MUC1 as reliable biomarkers of NPC; our findings may promote the development of NPC treatment strategy.
Bifidobacterium longum-Derived Extracellular Vesicles Prevent Hepatocellular Carcinoma by Modulating the TGF-β1/Smad Signaling in Mice
Authors: Li Bin , Chi Xiaochen , Huang Ying , Wang Weitong , Liu Zhuo
Published: June 2024

Background: The involvement of gut microbiota in carcinogenesis has gradually been highlighted in past decades. Bacteria could play its role by the secretion of extracellular vesicles (EVs); however, interrelationship between bacterial EVs and hepatocellular carcinoma (HCC) development has not been investigated much. Methods: Diethylnitrosamine (DEN) was utilized to produce HCC model in mice, of which fecal was collected for detecting Bifidobacterium longum (B.longum) with real-time polymerase chain reaction (PCR). EV isolated from B.longum (B.longum-EV) with ultracentrifugation were stained with PKH26 to investigate the cellular uptake of murine hepatocytes (AML12). After treatment with B.longum-EV, TGF-β1-induced AML12 cells were subjected to morphological observation, fibrosis- and apoptosis-related marker detection with western blot, apoptotic ratio and reactive oxygen species (ROS) level analysis with flow cytometry, and oxidative stress biomarker assessment with enzyme-linked immunosorbent assay (ELISA); meanwhile, animal studies including liver function, tumor formation rate, and histological analysis, were also performed to investigate the role of B.longum-EV in the fibrosis, apoptosis, oxidative stress, and carcinogenesis of the liver in vivo. Results: The levels of B.longum were significantly reduced in HCC model mice. B.longum-EV could enter AML12 cells and effectively attenuate TGF-β1-induced fibrosis, apoptosis, and oxidative stress in AML12 cells. In vivo studies showed that B.longum-EV administration alleviated DEN-induced liver fibrosis, apoptosis, and oxidative stress at the early stage. Moreover, B.longum-EV administration also effectively reduced the tumor formation rate and liver function injury in DEN-induced mice and down-regulated TGF-β1 expression and Smad3 phosphorylation of mouse liver. Conclusions: B.longum-EVs protect hepatocytes against fibrosis, apoptosis, and oxidative damage, which exert a potential of preventing HCC development.
The Development of Cardiac Rehabilitation in China: Current Status and Future Perspectives
Authors: Li Siwei , Xu Hao
Published: June 2024

In recent years, significant progress has been made in China in the field of cardiac rehabilitation by raising awareness among the Chinese public, scholars, hospitals, and government regarding the substantial benefits of cardiac rehabilitation/secondary prevention of cardiovascular diseases. Cardiac rehabilitation encompasses a comprehensive intervention strategy for cardiovascular diseases, integrating multiple disciplines, such as cardiology, sports medicine, rehabilitation medicine, nutriology, psychology, behavioral medicine, and preventive medicine. Standardized and systematic cardiac rehabilitation therapy can help patients with cardiovascular diseases restore their physical and mental health and reduce the risk of recurrences and deaths from cardiovascular diseases. This article provides an overview of the historical development, existing clinical practice modes, and the latest clinical research findings on cardiac rehabilitation, focusing on the current clinical modes and clinical research results of cardiac rehabilitation in China. It aims to offer a systematic perspective for international peers to know and understand cardiac rehabilitation in China, along with an objective analysis and future prospects for advancing this field.
In the Catheterization Laboratory, Most Iatrogenic Cardiac Tamponades Require Only Pericardiocentesis: A Single-Center Experience
Authors: Luo Hong , Wang Guangxia , Qin Chunchang , Jia Fengpeng , Shao Xiangsen
Published: June 2024

Background: Cardiac tamponade (CT) is a rare but life-threatening complication of cardiac interventions, requiring immediate pericardial cavity pressure relief. While pericardiocentesis often suffices, and some cases necessitate open-chest surgery. This decision is frequently based on individual physician’s experience. This study aims to identify high-risk CT patients following cardiac intervention, advocating for early, decisive surgical intervention. Methods: A retrospective analysis was conducted on 51 patients who developed iatrogenic CT at our center between October 2013 and October 2023. Patients were classified based on the necessity for open-chest surgery. The study evaluated a variety of factors, including baseline characteristics, therapeutic approaches, and outcomes. Results: Of the 51 patients with iatrogenic CT, 49 patients were successfully treated without open-chest surgery, with an average immediate drainage volume of 208.2 ± 173.8 mL. In contrast, the two patients requiring open-chest surgery had significantly higher drainage volumes, exceeding 500 mL, with over 300 mL drained in the first hour, indicating laceration injuries. Patients not requiring open-chest surgery demonstrated favorable outcomes. Conclusions: The majority of patients with iatrogenic CT and non-lacerated injuries experienced a favorable prognosis following pericardiocentesis. However, in cases of lacerated injuries with drainage volume was above 300 mL per hour, pericardiocentesis alone could not stabilize the hemodynamics due to persistent bleeding. Immediate surgery may be needed in these cases.
Five-Year Outcomes of Bioresorbable Stent Therapy for Coronary Heart Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Yang Fei-fei , Song Hui , Qin Wei-bin , Tang Wei-zhi , Zhan Ling-jun , Zhang Li-wen , He Gui-xin
Published: June 2024

Background: The efficacy of bioresorbable vascular scaffolds (BVS) compared to metallic stents for the treatment of coronary heart disease remains controversial. The analysis of clinical outcomes at five years following the initial treatment has yet to be reviewed. This study sought to assess the five-year outcomes in randomized controlled trials of BVS in the treatment of coronary heart disease using a systematic review and meta-analysis. Methods: A systematic database search was conducted from their inception to June 30th, 2023 using various Medical Subject Headings (MeSH) terms including: “Coronary Disease”, “Bioresorbable stent”, “Randomized controlled trials”. Results: After a rigorous selection process, a total of five high-quality articles were finally included in this study. Each trial demonstrated a low risk of bias. After 5 years, bioresorbable stents showed outcomes similar to conventional metal stents in terms of cardiac mortality. However, they were inferior in terms of lesion revascularization rates, in-stent thrombosis rates, target lesion failure, target vessel failure, and myocardial infarction. Conclusions: While bioresorbable stents are comparable to metallic stents in terms of cardiac mortality rates, they exhibit significant drawbacks that warrant clinical consideration.
The Impact of Geopolitical Tensions on International Capital Flows
Authors:   MGIMO University, Moscow, Russian Federation, Petrov M.V.
Published: June 2024

The study examines the impact of geopolitical tensions, which have increased sharply in recent times, on international capital flows. It shows that geopolitical tensions affect cross-border investment flows through three main channels: increased geopolitical risks that encourage international investors to reduce investments in countries with different foreign policies; tighter controls on incoming FDI in many countries to ensure national security; and financial sanctions imposed by Western countries to put pressure on other states. Based on the analysis of investment relations between the United States and China, the contradictions between which are the main source of geopolitical tension in the world, the author confirms the conclusion that the influence of geopolitical factors on capital flows between the countries has increased since the second half of the 2010s. However, the study substantiates that the emerging fragmentation of cross-border capital flows can have not only negative, but also positive consequences for the global economy and finance. The compression of capital flows between the countries of the global North and South may push the latter to establish closer integration ties in the financial sector, create financial infrastructure independent of the West, focused on the needs of developing countries, and accelerate the internationalization of their currencies. As a result, these processes could weaken the dominance of Western countries in the global financial system and facilitate its transition to a more equitable multipolar configuration.
Paradoxes of the Anti-crisis Role of Fiscal Federalism: Analytical Review of Studies
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russian Federation, Kireyeva A.F. , Rudy K.V. ,   Belarusian State Economic University, Minsk, Republic of Belarus
Published: June 2024

The analytical review of studies of the anti-crisis role of fiscal federalism during economic, ecological, epidemic challenges and territorial conflicts in 1950–2024 reveals four paradoxes. The first of them indicates the scientific validity of the positive anti-crisis effect of fiscal decentralization. But when crises arise in practice, decentralization turns out to be unclaimed, and preference is given to centralization. The second paradox is related to the nonlinear positive effect of fiscal decentralization on economic growth, natural resources consumption, and carbon emissions. For example, the nonlinear positive effect of decentralization is achieved when the institutional context is improved. The third paradox is the relatively weak methodological elaboration of fiscal federalism during pandemic challenges, although it had the greatest practical relevance compared to more in-depth econometric studies of economic and environmental challenges. The fourth paradox is that fiscal federalism can both resolve the territorial conflict and create the preconditions for its resumption in the future. The peacemaking conditions of fiscal federalism are transparency and stability of inter-budget transfers, as well as insured access of the conflict region to its natural resources.
Research on the Influence of Self-Efficacy, Training Motivation, and Training Outcomes on the Employment Intentions of Unemployed Youth in Taiwan Government Vocational Training Programs
Authors: Liu Che-Hung , Xiao Ru-Yi
Published: June 2024

This study originates from the observation of youth unemployment in Taiwan society and explores whether unemployed youth can successfully transition to the workplace through participation in Taiwan government vocational training. It examines the effects of individual self-efficacy, training motivation, and training effectiveness on employment intentions. The research method utilized a questionnaire survey, with a total of 121 questionnaires collected. SmartPLS and SPSS were used as statistical analysis software to conduct descriptive statistics, reliability and validity analysis, and regression analysis. The empirical results are as follows: self-efficacy has a significant positive impact on training effectiveness: a significant positive impact between self-efficacy and employment intentions; training motivation has a significant positive impact on training effectiveness; training motivation does not have a significant impact on employment intentions; and training effectiveness has a significant positive impact on employment intentions. In addition to the five hypotheses within the research framework, this study also conducted independent sample T-tests, one-way ANOVA, mediation effects, and moderation effects analyses, and got several empirical results as follows: training effectiveness partially mediates the impact of self-efficacy on employment intentions; males generally have higher self-efficacy than females; trainees who attempted to seek employment before training generally have higher employment intentions than those who did not; and trainees aged 25-29 generally have higher employment intentions than those aged 15-19.
Relationships between intimacy, passion, commitment and the level of stress in people in stable relationships.
Authors: Baryś Julia
Published: June 2024

The aim of the study was to examine the impact of intimacy, passion, commitment, and the number of children on stress levels in relationships. Correlation and linear regression analyses were conducted on a sample of 60 participants. The results indicate that intimacy has a significant negative impact on stress levels, while passion and commitment do not show a significant correlation with stress. The length of the relationship has a significant positive impact on the number of children with the current partner. The findings highlight the importance of building intimacy in a relationship as a crucial factor in reducing stress.
Penggunaan Teknologi dalam Mendukung Pendidikan Inklusif
Authors: Mutaalimah Nabilah
Published: June 2024

Sekolah inklusif adalah sekolah yang mengalokasikan semua anak tanpa terkecuali dalam satu ruangan tidak menghiraukan perbedaan kondisi fisik, intelektual, social, emosional dan kondisi lainya. Hal ini termasuk bagi anak yang cacat/berkelainan, anak yang malas belajar, anak yang tidak berbakat, anak jalanan dan anak yang berada di golongan bawah. Teknologi Pendidikan inklusi memberikan ruang yang sangat luas, terbuka, serta ramah tamah dalam pembelajaran, system pendidikan inklusi selalu mengutamakan perilaku saling menghargai atas perbedaan. Karena itu system teknologi pendidikan inklusi bertujuan untuk menghilangkan hambatan-hambatan dan memecahkan masalah serta mendukung pelaksanaan Pendidikan inklusi terhadap anak yang berkebutuhan khusus. Layanan ini bermaksud untuk tidak membeda-bedakan anak yang satu dangan yang lainya, tidak memandang latar belakangnya, ekonomi dan budaya, sehingga mereka bisa berkembang, belajar seperti anak-anak pada umumnya. Salah satu yang menjadi hal yang terpenting dari suksenya sebuah pendidikan inklusi yakni meningkatkannya kualitas dari tenaga pendidik
Prevalence of questionable health behaviors in Serbia and their psychological roots: Protocol for a nationally representative survey
Authors: Knezevic Goran , Lazarevic Ljiljana B. , Purić Danka , Zupan Zorana , Zezelj Iris
Published: June 2024

We will launch a national survey in Serbia to document the prevalence of two types of questionable health behaviors: 1) intentional non-adherence to medical recommendations (iNAR) and 2) use of traditional, complementary and alternative medicine (TCAM) practices, as well as the relation between the two. We will also investigate their psychological roots, including a. “distal” predictors such as HEXACO personality traits (plus Disintegration) and thinking dispositions (rational/experiential thinking and cognitive reflexivity), and b.“proximal” predictors under the umbrella “irrational mindset” (set of unfounded beliefs consisting of conspiratorial thinking, superstition, magical health beliefs as well as selected cognitive biases), which have more content-wise overlap with the health behaviors.Methods and AnalysisIn this cross-sectional study, a research agency will collect data from a nationally representative sample (N=1043; age 18–75 years; estimated start/end—June/November 2021) recruited online (approximately, 70% of the sample, aged 18–54;11 years) and face-to-face (approximately, 30% of the sample, aged 55–75 years). Participants will complete a battery of tests assessing questionable health behaviors, basic personality traits, thinking dispositions, irrational mindset, socio-political beliefs, socio-demographic and health-related variables. Prevalence rates will be calculated using descriptive statistics. To explore the relation between (psychological) predictors and questionable health behaviors we will use hierarchical regression and partial mediation models (path analysis or full SEM models).Ethics and DisseminationEthical Committees of the Faculty of Philosophy in Belgrade (#935/1), Faculty of Special Education and Rehabilitation (#139/1) and Faculty of Media and Communications (#228) approved the protocol. Only participants that provide informed consent will participate in the study. A research report based on the study results will be submitted to peer-reviewed journals and results will be made available to stakeholders through reports on the project website https://reasonforhealth.f.bg.ac.rs/en/ and disseminated via social media. The first and the second author equally contributed to the manuscript and share the first authorship.Trial registration number: NCT05808660
Mindfulness and Cognitive-Behavioral Strategies for Psychological Detachment: Comparing Effectiveness and Mechanisms of Change
Authors: Reis Dorota , Hart Alexander , Krautter Kai , Prestele Elisabeth , Lehr Dirk , Friese Malte
Published: June 2024

Recovering from work is essential for maintaining occupational well-being, health, motivation, and performance, but recovery is often difficult to achieve. In this study, we evaluated and compared the effectiveness of two (parallel) interventions aimed at promoting recovery: one based on mindfulness and one involving applying cognitive-behavioral strategies. Both interventions were embedded in a measurement burst design, which allowed us to examine the mechanisms underlying change or intervention success. To explore mechanisms of change, we used the stressor detachment model as a theoretical framework. We operationalized the interventions' effects in three ways: as changes from pretest to posttest, as changes in daily states, and as changes in daily associations. To this end, we used intensive longitudinal data to examine the roles that daily negative activation plays in detachment and strain. In a randomized controlled trial (N = 393), we administered three assessments of traits: pretest, posttest (8 weeks later), and follow-up (3 months after the posttest). We also administered 2 work weeks of experience sampling questionnaires (preintervention and postintervention). Latent change models and Bayes factor equivalence tests revealed that both interventions substantially—and to a similar extent—increased detachment. Bayesian multilevel path models showed improvements in all state variables, including improvements in negative activation, and provided some evidence that mindfulness-based and cognitive-behavioral approaches might tackle different processes at the daily level. We discuss theoretical implications for the literature on recovery from work and specifically for the stressor detachment model.
Commonly Used Statistical Models in Psychology are Not Equipped to Deal with Real-World Conditions: A Simulation
Authors: Sladekova Martina , Field Andy Peter
Published: June 2024

Ordinary Least Square (OLS) linear models produce non-optimal parameter estimates and biased hypothesis tests when their statistical assumptions are violated. In a recent study, we mapped out the extent to which OLS models in psychology meet the assumption of normal and homoscedastic errors reporting that violations are to be expected in practice. Here we simulated the conditions typical for psychology research and evaluated the performance of OLS models, bias-corrected and accelerated bootstrap, t-bootstrap, heteroscedasticity-consistent standard errors (HCSE), MM-estimator, Design Adaptive Scale Estimator, and robust trimming methods. We varied the level of skewness and kurtosis, heteroscedasticity, sample size, sample size ratio for group designs, effect size, type and number of predictors, and model design. We found that OLS outperformed other methods only in a narrow set of conditions. M-type estimators and trimming provided more accurate parameter estimates, while bootstrapping methods and HCSE outperformed other methods in light-tailed symmetrical distributions with heteroscedasticity. We discuss the utility of applying robust methods in conditions that are common is psychology research.