bluuebunny/crossref_metadata_2025 huggingface dataset:
Probiotic Lactobacillus plantarum GUANKE effectively alleviates allergic rhinitis symptoms by modulating functions of various cytokines and chemokines
Authors: Han Haijun , Chen Guoliang , Zhang Bin , Zhang Xuewen , He Jingmin , Du Wenjuan , Li Ming D.
Published: January 2024

Background

Currently, the prevalence of allergic rhinitis (AR) remains high and there is a great need to develop better and safer ways to alleviate AR symptoms. The Lactobacillus plantarum GUANKE probiotic was reported as an immunomodulator through maintaining Th1/Th2 balance. This study aimed to determine the efficacy of GUANKE in AR subjects.

Methods

Adults aged from 18 to 60 years old and previously suffered from AR were recruited and received GUANKE probiotics treatment for 4 weeks. The questionnaires of Total nasal symptom scores (TNSS), total non-nasal symptom score (TNNSS), and rhinitis control assessment test (RCAT) were used to assess the effectiveness before and after treatment. The serum allergen-specific IgE and cytokines were also determined at baseline and after 4 weeks of probiotics administration.

Results

The results showed that TNSS and TNNSS were significantly reduced and the RCAT score was significantly increased compared to baseline. The sub-symptom score of rhinorrhea, itching, sneezing, and tearing in each questionnaire also showed significant changes, and the serum IgE level was markedly decreased. We further measured inflammatory-related proteins in serum and found that a total of 20 proteins (6 upregulated and 14 downregulated) were significantly changed compared to baseline, including IL-4, IL-7, IL-20, IL-33, CXCL1, CXCL5, CXCL6, CXCL11, CCL4, CCL23, TGF-alpha, LAP-TGF-beta-1, MMP-1, MMP-10, AXIN1, NT-3, OSM, SCF, CD6, and NRTN. Enrichment analysis showed that these significantly altered proteins were mainly enriched in cytokine and chemokine-related signaling pathways.

Conclusion

Taken together, this study demonstrated the Lactobacillus plantarum GUANKE can serve as an effective immunobiotic for the treatment of AR, which is realized through maintaining the Th1/Th2 balance by modulating the functions of various cytokines and chemokines.
Cannabidiol and brain function: current knowledge and future perspectives
Authors: Schouten Moniek , Dalle Sebastiaan , Mantini Dante , Koppo Katrien
Published: January 2024

Cannabidiol (CBD) is a naturally occurring non-psychoactive cannabinoid found in Cannabis sativa, commonly known as cannabis or hemp. Although currently available CBD products do not meet the safety standards of most food safety authorities to be approved as a dietary supplement or food additive, CBD has been gaining widespread attention in recent years due to its various potential health benefits. While primarily known for its therapeutic effects in managing epileptic seizures, psychosis, anxiety, (neuropathic) pain, and inflammation, CBD’s influence on brain function has also piqued the interest of researchers and individuals seeking to enhance cognitive performance. The primary objective of this review is to gather, synthesize, and consolidate scientifically proven evidence on the impact of CBD on brain function and its therapeutic significance in treating neurological and mental disorders. First, basic background information on CBD, including its biomolecular properties and mechanisms of action is presented. Next, evidence for CBD effects in the human brain is provided followed by a discussion on the potential implications of CBD as a neurotherapeutic agent. The potential effectiveness of CBD in reducing chronic pain is considered but also in reducing the symptoms of various brain disorders such as epilepsy, Alzheimer’s, Huntington’s and Parkinson’s disease. Additionally, the implications of using CBD to manage psychiatric conditions such as psychosis, anxiety and fear, depression, and substance use disorders are explored. An overview of the beneficial effects of CBD on aspects of human behavior, such as sleep, motor control, cognition and memory, is then provided. As CBD products remain largely unregulated, it is crucial to address the ethical concerns associated with their use, including product quality, consistency, and safety. Therefore, this review discusses the need for responsible research and regulation of CBD to ensure its safety and efficacy as a therapeutic agent for brain disorders or to stimulate behavioral and cognitive abilities of healthy individuals.
The adverse events of CDK4/6 inhibitors for HR+/ HER2- breast cancer: an umbrella review of meta-analyses of randomized controlled trials
Authors: Pu Dongqing , Wu Yue , Xu Debo , Shi Guangxi , Chen Hanhan , Feng Dandan , Zhang Mengdi , Li Jingwei
Published: January 2024

Background: The clinical selection of three CDK4/6 inhibitors presents a challenging issue, owing to the absence of distinct clinical case characteristics, biomarkers, and their comparable clinical benefits in progression-free survival and overall survival To inform clinical treatment decisions, we conducted a comprehensive evaluation of the adverse events associated with CDK4/6 inhibitors in combination with endocrine therapy for hazard ratio+/HER2-breast cancer.

Methods: We searched Cochrane, PubMed, Embase, and Web of Science databases from their inception until 1 August 2022. The results were summarized narratively, and we assessed the methodological quality, reporting quality, and evidence quality of AEs by AMSTAR-2, PRISMA, and GRADE.

Results: Our analysis included 24 meta-analyses systematic reviews that evaluated the quality of AEs in 13 cases of early breast cancer (EBC) and 158 cases of advanced breast cancer The addition of CDK4/6 inhibitors was found to significantly increase AEs of any grade and AEs of grade 3 or higher in early breast cancer, along with a significant increase in the risk of treatment discontinuation. In advanced breast cancer, high and moderate-quality evidence indicated that CDK4/6 inhibitors significantly increased AEs across all grades, including grade 3/4 AEs, leucopenia, grade 3/4 leucopenia, neutropenia, grade 3/4 neutropenia, anemia, grade 3/4 anemia, nausea, grade 3/4 constipation, fatigue, pyrexia, venous thromboembolism abdominal pain, and cough. However, they did not significantly elevate the incidence of grade 3/4 diarrhea. Subgroup analysis revealed that palbociclib primarily increased hematologic toxicity, particularly grade 3/4 neutropenia, anemia, and thrombocytopenia. Ribociclib was mainly associated with grade 3/4 neutropenia, prolonged QT interval, and alopecia. Abemaciclib was closely linked with diarrhea and elevated blood creatinine levels.

Conclusion: The AEs associated with CDK4/6 inhibitors vary, necessitating individualized and precise clinical selection for optimal management. This approach should be based on the patient’s medical history and the distinct characteristics of different CDK4/6 inhibitors to improve the patient’s quality of life.

Systematic Review Registration: [https://systematicreview.gov/], identifier [CRD42022350167]
Structure of human GPR119-Gs complex binding APD597 and characterization of GPR119 binding agonists
Authors: Li Ruixue , Qian Yuxia , Wang Jiening , Han Zhen , Ye Sheng , Wu Shan , Qiao Anna
Published: January 2024

The rhodopsin-like receptor GPR119 plays a crucial role in glucose homeostasis and is an emerging target for the treatment of type 2 diabetes mellitus. In this study, we analyzed the structure of GPR119 with the agonist APD597 bound and in complex with the downstream G protein trimer by single particle cryo-electron microscopy (cryo-EM). Structural comparison in combination with function assay revealed the conservative and specific effects of different kinds of GPR119 agonists. The activation mechanism of GPR119 was analyzed by comparing the conformational changes between the inactive and active states. The interaction between APD597 derivatives and synthetic agonists with GPR119 was analyzed by molecular docking technique, and the necessary structural framework was obtained. The above conclusions can provide structural and theoretical basis for the development of therapeutic drugs for type 2 diabetes mellitus.
Why do democracies respond differently to COVID-19? A comparison of the United States and South Korea
Authors: Mao Yexin
Published: January 2024

Background

COVID-19 has posed severe challenges to crisis management in democracies. Different democracies respond to the crisis differently. This article proposes an analytical framework to explain why democracies respond differently to the public health crisis and how different contextual factors affect crisis response in democracies.

Methods

By comparing COVID-19 responses in the US and South Korea, this article conducts a comparative case study with a most similar system design. The two countries have been selected as cases because they are both developed democracies with a robust healthcare system. However, different contextual factors in the two countries have created different crisis responses by shaping different crisis leadership and political and social solidarity. This study collected data from different sources, including government documents, official websites, leaders’ speeches, research reports, academic articles and news media. We tried to enhance the reliability of the data by comparing different data sources.

Results

We found that individual, institutional and cultural dimensions of contextual factors can influence different crisis responses of democratic countries by shaping crisis leadership and political and social solidarity. On the individual and institutional dimensions, leadership style and governance structure shape crisis leadership (sense making, decision making and coordinating, and meaning making), which in turn influences crisis management. On the cultural dimension, political and social solidarity measured by political polarization and social cooperation are shaped by cultural and social norms.

Conclusion

Our findings indicate that democracies require strong crisis leadership and a high degree of political and social solidarity to tackle public health crises. A centralized and coordinated system, as well as a political elite leadership style shaped by rich crisis response experience, expertise and high sensitivity to crises are conducive to crisis management. Fostering a cultural and social norm that facilitates state–society collaboration can promote crisis management. These findings provide valuable insights for decision-makers to effectively respond to future pandemics.
Community health nurses' concerns about infant regulatory problems are predictive of mental disorders diagnosed at hospital: a prospective cohort study
Authors: Pant Sofie Weber , Holstein Bjørn Evald , Ammitzbøll Janni , Skovgaard Anne Mette , Pedersen Trine Pagh
Published: January 2024

Introduction

Regulatory problems of eating, sleeping, and crying in infancy may index mental health vulnerability in older ages, and knowledge is needed to inform strategies to break the developmental trajectories of dysregulation in early childhood. In this study, we examined the prospective associations between infant regulatory problems at the age of 8–10 months identified by community health nurses (CHN) and mental disorders diagnosed in hospital settings in children aged 1–8 years.

Methods

From a cohort of all newborn children in 15 municipalities in the Capital Region of Copenhagen (N = 43,922) we included all children who were examined by CHNs at the scheduled home visit at the age of 8–10 months (N = 36,338). Outcome measures were ICD-10 mental disorders diagnosed at public hospitals and reported to the National Patient Register. Logistic regression included data on child and family covariables obtained from population registers.

Results

The CHNs reported concerns regarding sleep in 7.7% of the study population, feeding and eating in 19.1%, combined sleeping and eating problems in 3.6%, and incessant crying in 0.7%. A total of 1,439 children (4% of the study population) were diagnosed in hospital settings with an ICD-10 mental disorder between the ages of 11 months and 8 years. Analyses adjusted for a range of perinatal and family adversities showed an increased risk of any neurodevelopmental disorder among children with CHN concerns of feeding and eating (odds ratio (OR) 1.36 (95% confidence interval (CI) 1.14–1.63)) and co-occurrent problems of feeding and eating and sleep (OR 1.60 (95% CI 1.14–2.26)). For autism-spectrum disorders, an increased risk was seen among children with co-occurrent problems of both feeding and eating and sleep (OR 1.73 (95% CI 1.07–2.79)). Concern about feeding and eating was also associated with an increased risk of behavioral and emotional disorders (OR 1.27 (95% CI 1.03–1.56)). Concern about incessant crying at the age of 8–10 months was not associated with a diagnosed mental disorder, but findings may reflect low statistical power due to low frequency of concern.

Discussion

CHN concerns mirror a group of developmentally vulnerable children. Further research is needed to explore the possibilities of preventive intervention within the general child health surveillance to address the developmental psychopathology of dysregulation in early ages.
The magnitude of correlation between deadlift 1RM and jumping performance is sports dependent
Authors: Schiemann Stephan , Keiner Michael , Wirth Klaus , Lohmann Lars H. , Wagner Carl-Maximilian , Behm David G. , Warneke Konstantin
Published: January 2024

Introduction

Based on the assumption of maximal strength as a basic ability, several studies show a high influence of maximum strength on jumping performance in several sport athletes. However, there is a wide range of correlations from r = 0.17–0.9 between squat 1RM and jumping performance in different sports. Additionally, there are only a few studies investigating the influence of deadlift one repetition maximum (1RM) on jumping performance. Thus, this study aimed to investigate the correlations between 1RM in the deadlift on jumping performance using the countermovement jump height (CMJ) and squat jump height (SJ) considering different sports.

Methods

103 athletes with experience in the deadlift from soccer, basketball, American football, powerlifting as well as participants from different sports without any deadlift experience (control group) were included to this study.

Results

Overall statistics showed a significant moderate influence of deadlift 1RM (r = 0.301–0.472) on jumping performance. However, subgroup analysis showed no significant correlation between deadlift 1RM and jumping performance in control participants, while moderate correlations could be detected in powerlifters (r = 0.34–0.39), soccer players (r = 0.437–0.46), American football players (0.584–0.62) and high correlations in basketball players (r = 0.809–0.848) showing significant influence of type of sport on correlations between deadlift maximum strength and jumping performance.

Discussion

Presented results underline movement velocity- and task specificity of strength training routines which is discussed in the light of the respective sports.
Does sedation with AQUI-S® mitigate transport stress and post transport mortality in ballan wrasse (Labrus bergyltae)?
Authors: Calabrese Sara , Jonassen Thor Magne , Steigum Endre , Åsnes Helga Øen , Imsland Albert Kjartan Dagbjartarson , Saude Carolina Serra , Wergeland Truls , Höglund Erik
Published: January 2024

Ballan wrasse (Labrus bergylta) are commonly used as cleaner fish in salmon farms as a biological treatment to mitigate sea lice infestation. Improved welfare for cleaner fish both during production of these fish and when in sea-cages with salmon is crucial for the industry’s development. A common operational procedure in ballan wrasse production is transporting juveniles from one land-based farm to another for further on-growing. Episodes of increased mortality have been reported after such transportations. In this study, the relationship between transport stress and post-transport mortality at the on-growing facility was examined. It was also investigated if light sedation with AQUI-S®can mitigate stress during transport. Stress was quantified by measuring cortisol release rate to the tank water during transport. This was investigated in 10 commercial live carrier truck transports (6 without AQUI-S®sedation and 4 with sedation during loading and transport). The total time of transport varied between 12 and 21 h. In general, mortality was significantly higher (1.0 ± 0.6% day−1) the first five days post-transport compared to 15–20 days post transport (0.5% day−1). There was also a strong relationship between fish weight at transport and post-transport mortality, where higher mean weight at transport reduced mortality. In contrast to what was expected, AQUI-S®treatment during transport procedures increased cortisol excretion rate, suggesting a stimulating effect of AQUI-S®on the stress axis in ballan wrasse. Considering these results, the value of using AQUI-S®to reduce stress during transport of juvenile ballan wrasse might be questioned. However, there was no relationship between cortisol release rate during transport and post-transport mortality. Furthermore, this study emphasizes that water cortisol measurements can be used as a none-invasive tool for monitoring stress and can be integrated into the welfare evaluation during commercial fish transports.
A Systematic Approach to Identify and Manage Interface Risks between Project Stakeholders in Construction Projects
Authors: Okika Michael C. , Vermeulen Andre , Pretorius Jan-Harm C.
Published: January 2024

Interface risks are inherent in every construction project from start to finish. Identifying and managing these risks effectively in every project phase is crucial for actualising project objectives. This paper shows a comprehensive framework showing several relationships between project stakeholders and how the interface risks between them that influence project execution are identified and managed for the overall construction project success. Firstly, a literature review on interfaces and interface risks and a discussion on how organisations managed interface risks were carried out, and secondly, the collection of quantitative data was conducted by means of structured online questionnaires. The sample consisted of 205 construction project professionals who were selected randomly. This group included individuals with various roles in the construction industry. The data were analysed using descriptive statistical methods, including factor analysis, reliability assessment, and calculations of frequencies and percentages. The results showed all the factors, work cultures, and organisational approaches that influence interface risk management and ways to identify and manage interface risks effectively. Effective stakeholder management is crucial for effective interface risk management since many interface risks are created by the numerous stakeholders involved in the project and the proposed frameworks will effectively mitigate the consequences and causes of interface risks. Effectively mitigating these risks involves effective stakeholder management, building information modelling volume strategy, and creating a virtual construction model during the construction phase; in addition, construction supply chain risks must be carefully identified during the interfaces establishment stages; interface risks must be carefully identified during the conceptualisation; and the planning, construction, and execution stages and standard methods and procedures must be defined to effectively identify and manage interface risks as the occur in the project lifecycle plus implementing the proposed risk mitigation frameworks.
The Effect of Laser-Cladded Co6, T400, and Ni-Based 30WC Coatings on the Wear Resistance of H13 Steel
Authors: Zhang Haibo , Zhuang Jingyu , Li Juncheng
Published: January 2024

To enhance the wear resistance of H13 steel (4Cr5MoSiV1), Co6, T400, and Ni-based 30WC coatings were applied to the surface of H13 steel using laser cladding technology. The microstructures and phase compositions of the three coating types were analyzed using SEM and XRD methods. The high-temperature friction and wear performance of the three coated samples and H13 steel were measured through high-temperature friction wear tests, and the friction wear types of the four samples were analyzed. A comparative analysis of experimental data led to the following conclusions: (1) Among the four samples, the Ni-based 30WC-coated sample exhibited the best self-lubricating properties. (2) The average wear area of H13 steel was 0.059 mm2, and the wear volume was 0.29 mm3; the average wear area of Co6-coated samples was 0.050 mm2, and the wear volume was 0.25 mm3; the average wear area of T400-coated samples was 0.002 mm2, and the wear volume was 0.01 mm3; and the average wear area of the Ni-based 30WC-coated sample was 0.035 mm2, and the wear volume was 0.17 mm3. In terms of wear resistance, the ranking from highest to lowest was: T400-coated sample > Ni-based 30WC-coated sample > Co6-coated sample > H13 steel. (3) Based on the classification of friction wear types, H13 steel primarily exhibited adhesive wear and oxidized wear; the Co6- and T400-coated samples primarily showed adhesive wear, abrasive wear and oxidized wear; and the Ni-based 30WC-coated sample mainly exhibited abrasive wear and oxidized wear.
Experimental Characterization of an AC–DC Boost for Energy Harvesting Device Based on Magnetostrictive Materials
Authors: Clemente Carmine Stefano , Davino Daniele , Iannone Immacolato , Loschiavo Vincenzo Paolo
Published: January 2024

Magnetostrictive alloys hold great promise for Energy Harvesting applications due to their inherent durability. However, their implementation often results in usable voltage ranges that fall significantly below common electronic standards like 1.6, 3.3, and 5 volts. Consequently, the utilization of electronic circuits becomes essential to amplify the voltage and enhance energy conversion efficiency. Over the past few decades, numerous conversion techniques have been devised for other intelligent materials, such as piezoelectrics, some of which have even made their way into commercial products. Surprisingly, there is a dearth of specialized techniques, if not a complete absence, tailored to magnetostrictive devices. Among potential solutions, a suitable AC–DC Boost converter stands out as a highly promising candidate for addressing this challenge, but this solution has never been fully characterized. Then, this paper presents thorough experimental validations of such a converter, driven by a real-time Arduino board equipped to measure source time periods and operate under various conditions. We present several cases demonstrating the circuit’s substantial potential for enhancing energy harvesting from magnetostrictive materials.
A State-of-the-Art Review on Computational Modeling of Dynamic Soil–Structure Interaction in Crash Test Simulations
Authors: Yosef Tewodros Y. , Faller Ronald K. , Fang Chen , Kim Seunghee
Published: January 2024

The use of nonlinear, large-deformation, dynamic finite element analysis (FEA) has become a cornerstone in crash test simulations, playing a pivotal role in evaluating the safety performance of critical civil infrastructures, including soil-embedded vehicle barrier systems. This review paper offers a detailed examination of numerical modeling methodologies employed for simulating dynamic soil–structure interactions in crash test simulations, with a particular focus on dynamic impact pile–soil interaction. This interaction is a critical determinant in assessing the effectiveness of soil-embedded barrier systems during vehicular impacts. Our extensive review methodically categorizes and critically evaluates four prevalent modeling methodologies: the lumped parameter method, the subgrade reaction method, the modified subgrade reaction approach, and the direct or mesh-based continuum method. We explore each methodology’s underlying philosophy, strengths, and shortcomings in accurately simulating the dynamic interaction between soil and piles under impact loading. This technical review aims to provide a thorough understanding of the critical and distinctive aspects of modeling soil’s dynamic responses under impact loading conditions. Moreover, this paper is envisioned to serve as a foundational reference for future research endeavors, steering the advancement of innovative simulation techniques for tackling the dynamic impact soil–structure interaction problem.
Validation of the Lithuanian Version of the Walking Impairment Questionnaire in Patients with Peripheral Arterial Disease
Authors: Baltrūnas Tomas , Medelis Karolis , Melaikaitė Augustė , Račytė Austėja , Pikturnaitė Gabija , Baltušnikas Rokas , Laucevičienė Ieva , Ručinskas Kęstutis
Published: January 2024

Background and Objectives: The Walking Impairment Questionnaire (WIQ) is a short and simple tool to measure walking impairment for patients with peripheral arterial disease requiring no special equipment or trained staff. The aim of this study was to assess the validity and reliability of the culturally adapted Lithuanian WIQ version in patients with intermittent claudication. Materials and Methods: In total, 40 patients with intermittent claudication and ankle–brachial index < 0.90 participated in this study. Reliability and internal consistency of the questionnaire were assessed by the intra-class correlation coefficient (ICC) and Cronbach’s alpha (α), respectively. Validity was determined by correlations between the WIQ scores and a subjective test (Quality of Life 5 Dimension Questionnaire 3 Level Version (EQ-5D-3L)) and objective tests (6 min walk test (6MWT), treadmill test, and ankle–brachial index). Results: The test–retest reliability was assessed as excellent with an intraclass correlation coefficient of 0.90. The values of Cronbach’s alpha were 0.957 (I time) and 0.948 (II time) and indicated an excellent internal consistency. Statistically significant Spearman correlations were detected between the WIQ and walking distances on the 6MWT (rho 0.514, p < 0.001) and treadmill test (rho 0.515, p < 0.001). Higher WIQ scores were associated with longer walking distances and duration. Moderate negative and low negative correlations were found between the WIQ and EQ-5D-3L scores. Conclusions: The Lithuanian version of culturally adapted WIQ demonstrates reliability and validity for patients with intermittent claudication, supported by two different walking tests showing statistically significant moderate Spearman correlations.
Artificial intelligence in healthcare
Authors:   Department Ministry of Science and Higher Education of the Russian Federation, Ustinovich Elena Stepanovna
Published: January 2024

Research on the issues and problems of the introduction of artificial intelligence into various spheres of life of a modern individual, the society, and the state are in the trend of scientific research at the present stage of information technology development. Artificial intelligence (AI) is being used now more than ever before, especially in the healthcare sector. Artificial intelligence has provided a more efficient way to automate routine work and other daily tasks, as well as manage patients and medical resources. The system can perform most of the tasks previously performed by humans, making it faster and cheaper. This significant advantage has facilitated the activities of interacting parties in the healthcare sector, doctors and patients. Artificial intelligence continues to gain momentum. Currently, there are modern machine learning solutions that can act, learn, understand, and predict. This is a step forward compared to robotic assistants in surgical interventions and the binding of genetic codes previously controlled by artificial intelligence. The article demonstrates that the development of artificial intelligence in healthcare involves some risks and problems — artificial intelligence systems expose patients to the risk of injury, and patient data for use in artificial intelligence systems involve the risk of privacy invasion. The article shows the advantages and disadvantages of the introduction of artificial intelligence in the field of healthcare, and the necessary conclusions are drawn.
HUBUNGAN DUKUNGAN KELUARGA DENGAN TINGKAT KECEMASAN PADA PENYINTAS COVID-19 DI RW 007 DESA CILEUNGSI KIDUL
Authors: Jilani Upra , Istiqomah Istiqomah
Published: January 2024

Pendahuluan Covid-19 memberikan dampak psikis bagi masyarakat Indonesia khususnya di daerah Cileungsi Desa Cileungsi Kidul RW 007. Salah satu dampak psikis yang dialami adalah kecemasan. Para penyintas covid-19 sangat rentan mengalami kecemasan. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara dukungan keluarga dengan tingkat kecemasan pada penyintas covid-19 di RW 007 Desa Cileungsi Kidul. Metode Penelitian yang digunakan adalah deskriptif korelasi. Sampel diambil dengan teknik Total Sampling sebanyak 30 responden. Teknik analisa penelitian menggunakan analisa univariat dan bivariat menggunakan Chi-Square α=5%. Hasil penelitian menunjukan hasil univariat dukungan keluarga mayoritas baik sebanyak 25 (83,3%) dan tingkat kecemasan tidak cemas sebanyak 16 (53,3%). Hasil analisis bivariat diperoleh nilai p Chi-Square 0,213 nilai ini lebih besar dari α = 5% maka H0 diterima. Simpulan tidak ada hubungan dukungan keluarga dengan tingkat kecemasan pada penyintas covid-19 di RW 007 Desa Cileungsi Kidul. Saran agar masyarakat dapat memberikan informasi yang jelas dan penting mengenai covid-19 yang membuat penyintas covid-19 selalu merasa tenang dan tidak merasakan cemas serta memberikan semangat, support atau motivasi, serta memberikan perasaan yang nyaman, sehingga dapat menekankan tingkat kecemasan dan firasat buruk yang mungkin dialami oleh penyintas covid-19.
HUBUNGAN POLA ASUH ORANG TUA DENGAN PERKEMBANGAN EMOSIONAL ANAK USIA PRSEKOLAH (4 -6 TAHUN) DI TK NEGERI PENGGILINGAN JAKARTA TIMUR
Authors: Wahyuni Salvirah Eko , Meilita Zuhriya
Published: January 2024

Perkembangan emosional pada anak merupakan bentuk komunikasi perasaan anak sehingga perlu mendapatkan stimulasi yang baik agar tidak menimbulkan ketegangan emosi seperti anak sulit bergaul, hiperaktif, tantrum, mudah menangis, dan memiliki perilaku agresif sehingga berakibat pada mental di masa anak, remaja hingga dewasa kelak. Salah satu faktor yang mempengaruhi perkembangan emosional anak adalah pola asuh orang tua yang mencangkup pola asuh demokratis, otoriter dan permisif. Metode Penelitian deskriptif korelatif dengan teknik probability sampling dengan metode total sampling. Jumlah sampel 60 orang tua di TK Negeri Penggilingan Jakarta Timur. Analisis yang digunakan univariat dan bivariat menggunakan chi-square a= 5% . Hasil penelitian Orang tua anak di TK Negeri Penggilingan Jakarta Timur menerapkan pola asuh demokratis 41 (68,3%), otoriter 14 (23,3%)

dan permisif 5 (8,3%). Perkembangan emosional anak 37 (61,7%) anak dalam kategori normal, 18 (30%) anak dalam kategori borderline dan 5 (8,3%) anak dalam kategori abnormal. Hasil chi-square didapatkan nilai Asymp.Sig (2-sided) sebesar 0.000 (p<5%). Simpulan terdapat hubungan pola asuh orang tua dengan perkembangan emosional anak yang kuat dengan nilai keeratan 0,768. Saran diharapkan adanya kerjasama oleh TK Negeri Penggilingan dalam memberikan penyuluhan kepada orang tua mengenai pola asuh yang tepat guna menunjang perkembangan emosional anak agar dapat berkembang dengan baik.
HUBUNGAN KOPING STRES DENGAN MOTIVASI BELAJAR PADA MAHASISWA S1 KEPERAWATAN DI FAKULTAS ILMU KESEHATAN UNIVERSITAS ISLAM AS-SYAFI’IYAH
Authors: Purwanti Tri , Seniwati Seniwati
Published: January 2024

Koping stres merupakan suatu proses yang dinamis individu mengubah secara konstan pikiran dan perilaku mereka dalam merespon perubahan-perubahan dalam penilaian terhadap kondisi stres dan tuntutan-tuntutan, World Health Organization mencatat 27% di Asia tenggara yang mempunyai kasus stres terbanyak, dan dapat meningkatkan resiko kematian hingga 43%. Tujuan Penelitan ini untuk menganalisis hubungan koping stres terhadap motivasi belajar. Metode Penelitian deskriptif kuantitatif dengan cross sectional (potong lintang). Jumlah populasi 200 responden. Sampel yang dipilih sebanyak 133 responden. Pengumpulan data menggunakan Kuesioner selanjutnya dianalisis menggunakan Chi-Square. Hasil Penelitian koping stres sebanyak 71 responden (53.4%) mendapatkan koping stress yang baik, 62 responden (46.6%) mendapatkan koping stres yang buruk, dan 72 mahasiswa (54.1%) mendapatkan motivasi belajar tinggi, 61 mahasiswa (45.9%) mendapatkan motivasi belajar yang rendah, hasil Penelitian dari Chi-Square didapatkan bahwa nilai Asymp. Sig. (2-sided) : 0.003 nilai ini lebih besar a=5% maka hipotesis H1 diterima dan H0 ditolak. Kesimpulan terdapat hubungan koping stres dengan motivasi belajar pada mahasiswa S1 Keperawatan Di Fakultas Ilmu Kesehatan Universitas Islam As-Syaf’iyah dengan nilai 0,003 terdapat kategori rendah. Ini menunjukan tingkat hubungan koping stress dengan motivasi belajar yang rendah.  Saran diharapkan pada peneliti selanjutnya dapat melakukan penelitian dengan variabel lain yang dapat mempengaruhi motivasi belajar contohnya kemampuan belajar, kondisi lingkungan dan unsur-unsur dinamis belajar.
PENDIDIKAN KESEHATAN DALAM PEMBERIAN MPASI DAPAT MERUBAH PERILAKU IBU DALAM MENCEGAH STUNTING DI WILAYAH KERJA PUSKESMAS SINGOTRUNAN KABUPATEN BANYUWANGI
Authors: Indriani Ninis , Nazmi Annisa Nur
Published: January 2024

Stunting merupakan bentuk kegagalan pertumbuhan akibat akumulasi ketidakcukupan nutrisi yang berlangsung lama mulai dari kehamilan sampai usia 24 bulan. Salah satu penyebab stunting adalah praktik pemberian MPASI yang kurang tepat pada bayi dibawah 2 tahun. Tujuan penelitian ini adalah Untuk mengetahui pengaruh Pendidikan kesehatan tentang pemberian MPASI terhadap pengetahuan dan perilaku ibu dalam upaya pencegahan stunting di wilayah kerja puskesmas singotrunan Kabupaten Banyuwangi tahun 2022. Metode Penelitian menggunakan penelitian kuantitatif dengan populasi sebanyak 45 responden dan menggunakan tekhnik purporsive sampling dengan sample 30 responden, analisis yang digunakan univariate dan bivariat dengan wilcoxon sign rank  p> α = 0,05. Hasil Penelitian diperoleh nilai signifikan p<0,5 maka 0,000 < 0,05 yang bermakna Ho ditolak dan Ha diterima yang artinya ada pengaruh yang signifikan Pendidikan kesehatan tentang pemberian MPASI terhadap pengetahuan dan perilaku ibu dalam upaya pencegahan stunting di wilayah kerja Puskesmas Singotruna Kabupaten Banyuwangi Tahun 2022.
INFLUENCE OF MECHANOCHEMICAL SYNTHESIS DURATION ON STRUCTURAL AND MORPHOLOGICAL CHARACTERISTICS OF CALCIUM SILICATE DISPERSION
Authors: Shoshin E. , Babajanyan A. , Glivenko I. , Kovalev D.
Published: January 2024

Mechanochemical synthesis of sucrose-modified calcium hydrosilicates as precursors of calcium silicate dispersions – polyfunctional additives for cement systems was carried out on a fine grinding vibromill VM-20. The influence of duration of mechanochemical synthesis of modified hydrosilicates on the phase composition of calcium silicate dispersions, morpho-structural characteristics of the nanostructured calcium silicate xerogel particles, as well as technological features of the reaction mass of mechanochemical synthesis was studied. It was found that the viscosity of the reaction mass of mechanochemical synthesis changes non-monotonically during synthesis: in the first 2 hours of mechanochemical synthesis, the viscosity decreases; subsequently, the viscosity of the mixture increases slightly; the reaction mass maintains high fluidity throughout the entire synthesis process; the presence of raw mineral materials in the reaction mass continues to be fixed throughout the synthesis (up to 7 hours); recrystallization processes of synthesized weakly crystallized phases are activated after 6 hours of grinding.

The volume of the synthesized xerogel was estimated from the specific surface area of the calcium silicate dispersion. It was found that the processes of recrystallization of weakly crystallized phases synthesized during mechanochemical synthesis do not affect the volume of xerogel in the composition of calcium silicate dispersion, the specific surface area of the calcium silicate dispersion increases in proportion to the duration of the mechanochemical synthesis of modified calcium hydrosilicates. The duration of mechanochemical synthesis does not affect the morpho-structural characteristics of coagulation xerogel particles.
Fen Bilimleri Öğretmenlerinin Elektriğin İletimi Ünitesinin Öğretiminde Kullanılabilecek Bağlam Bilgisi Önerilerinin Belirlenmesi
Authors: ACET İlyas , KURNAZ Mehmet Altan
Published: January 2024

Araştırma, elektriğin iletimi ünitesinde fen bilimleri öğretmenlerinin bağlam önerilerini tespit etmek amacıyla yapılmıştır. Tarama çalışması olarak yürütülen bu araştırmanın çalışma grubunu, Türkiye’nin 7 coğrafi bölgesinde görev yapan 178 fen bilimleri öğretmeni oluşturmaktadır. Araştırmanın verileri 6.sınıf fen bilimleri dersi öğretim programındaki ilgili üniteye ait her bir kazanım için hazırlanan açık uçlu sorular ile toplanmıştır. Veriler içerik analizine tabi tutulmuştur. Elde edilen bulgulara göre öğretmenler 6.sınıf elektrik konusunda en çok “iletken ve yalıtkan maddeler, elektriğin taşınmasında iletkenlerin kullanımı, değişken direnç, benzeşim (analoji), enerji dönüşümü” içeriklerini bağlam olarak önermektedir. Bunun yanı sıra fen bilimleri öğretmenlerinin öğretim programına uygun olmayan (kazanımla ilişkisiz) bağlam önerdikleri ve kazanımları bağlamlaştırmada zorlandıkları tespit edilmiştir. Elektriğin iletimi ünitesi için ülke geneline yönelik öğretim materyali tasarlayacak ilgili paydaşların, bulgulardan hareketle, fen bilimleri öğretmenleri tarafından sunulan bağlam örneklerini dikkate almaları önerilmektedir.
Müzik Öğretmeni Adaylarının Beş Büyük Kişilik Özelliklerinin Çalgı Öz Yeterlik Durumlarını Yordaması
Authors: BÖLEK Aze , COŞKUN ŞENTÜRK Gülce
Published: January 2024

Bu araştırmanın amacı, müzik öğretmeni adaylarının beş büyük kişilik özelliklerinin çalgı öz yeterlik durumlarını yordama durumunu incelemektir. Araştırmanın amacı doğrultusunda ilişkisel tarama modeli kullanılmıştır. Araştırmanın evrenini; Türkiye’nin Ege Bölgesinde bulunan müzik eğitimi anabilim dallarında öğrenim gören öğrenciler oluşturmaktadır. Araştırmanın örneklemi, Ege Bölgesinde yer alan Muğla, Denizli, Aydın, İzmir illerindeki müzik eğitimi anabilim dallarında öğrenim gören 378 öğrenci ile gerçekleştirilmiştir. Araştırmadan elde edilen sonuçlarda, müzik öğretmeni adaylarının çalgı öz yeterlik durumları 10 puan üzerinden 5.54 olarak tespit edilmiş ve çalgı öz yeterlik ölçeği ile çalgı solo performans ve çalgı genel not ortalaması değişkeni arasında pozitif yönde anlamlı ilişkiler olduğu saptanmıştır. Diğer taraftan dışa dönüklük, öz disiplin ve açıklık kişilik özelliği ile solo performans arasında p
Counselor candidates’ experiences regarding counselling supervision
Authors: APAYDIN Seval , ÇAKIR ÇELEBİ S. Gülfem
Published: January 2024

Supervision process, which plays a critical role in the professional development of counselor candidates, is an important part of counselor education. In this sense, an increasing number of studies have focused on understanding the supervision process in recent years. Thus, this research, designed as a case study, aimed to investigate counselor candidates’ experiences during individual counseling supervision process. The study group included ten female and five male senior students in guidance and counseling undergraduate program. The participants carried out six to eight individual counseling sessions with their clients under supervision. During the supervision process, both individual and group supervision sessions were carried out and the supervisees took feedback from the supervisors and their peers. Study data were collected with an evaluation form containing 11 open-ended questions to obtain student experiences. Content analysis results yielded four themes: a) challenges, b) facilitative elements, c) professional and personal development, and d) suggestions. The findings were discussed in the light of existing literature and recommendations for counseling supervision were presented.
Mathematics Homework View from the Perspective of Primary School Students' Parents
Authors: KAYGISIZ İsmail
Published: January 2024

This research was carried carried to reveal the opinions of the parents of primary school students about mathematics homework. The research was designed with the case study model, which is one of the qualitative research methods. The study group of the research consists of 26 parents whose children are studying in a primary school in the central of Konya, Provincial Directorate of National Education in the 2022-2023 academic year. Care was taken in the selection of an equal number of participants from each grade level. The parents were selected using criterion sampling, one of the purposive sampling methods. The research data were collected with a semi-structured interview form and the interviews were recorded on a voice recorder. The semi-structured interview form prepared by the researcher consists of five questions aiming to reveal the views of the parents of primary school students on mathematics homework. Content analysis method was used in the analysis of the data. Parents participating in the research define mathematics homework as reinforcement and repetition. Parents are involved in mathematics homework as control or direct support. Although students usually allocate half an hour for their math homework, this time is less in the 1st and 2nd grades, and more in the 3rd and 4th grades. According to the parents, teachers check the homework constantly and in detail. It has been concluded that the students love to do short-term homework using technological tools, made with concrete materials, and they do not like to do long-term homework that requires writing.
Metaphorical Perspectives of Art Educators and Students on the Concept of Art Studio in Distance Education
Authors: ÇAĞLAYAN Evrim
Published: January 2024

As old as the history of humanity, art has been practiced in various places throughout the ages. The concept of art studio, which is generally associated with artistic activities, is also associated with many craft branches. Woodworking and carpentry, blacksmithing, pottery, carpet making, etc. professions are also practiced in studios. Art educators and students using art studios in education have had to leave these spaces during the Coronavirus (Covid-19) pandemic. The transition to distance education after the pandemic has left the art studios empty. This abandonment undoubtedly caused transformations in their perceptions. The main subject of this research is the metaphors produced about the concept of art workshop in distance education. This research aims to reveal the metaphorical perspectives of higher education art educators and students about the concept of 'art studio' in distance education. Metaphor analysis, one of the qualitative research methods, was used in conducting this research. It is seen that art educators and students created a total of 27 types of metaphors under seven categories for the concept of art studio. The metaphors that the participants stated the most were listed as house, life, kitchen, factory, and pal. It can be suggested that similar studies can be conducted with younger age groups of students studying at different educational levels.
Diferentes métodos de motivação no tratamento periodontal – revisão de literatura
Authors: Schussler Eliezer Canabarro , Picoli Adrielen Henrique , Dias Jose Roberto da Silva
Published: January 2024

Por muito tempo pensou-se que o controle de placa era de responsabilidade única do paciente, contudo, atualmente sabe-se que essa responsabilidade é dividida entre profissional/paciente. Cabendo ao profissional motivar o paciente para que tenha uma melhora na sua condição de higiene bucal.  O objetivo do presente estudo foi buscar na literatura técnicas diferenciadas de motivação ao paciente periodontal, buscar resultados obtidos em estudos e discutir a respeito da motivação na doença periodontal. Para isso foi feita uma busca bibliográfica em Pubmed e Bireme, entre outros. Foram buscados trabalhos principalmente a partir do ano de 2000. Os resultados encontrados evidenciam a importância da motivação ao paciente peridontal. Técnicas empregadas como palestras ministradas pelos profissionais, vídeos, visualização de folders explicativos sobre a doença peridontal, explicação em macro modelo da higienização correta entre outras. Os artigos aqui apresentados, de uma maneira geral, discutem a importância em diferenciar os métodos de motivação aplicados, nos quais os pacientes que tiveram essa motivação extra, apresentaram os melhores níveis de higiene bucal em relação aqueles que não participaram de forma direta do método do grupo de motivação. Conclui-se que o profissional deve motivar o paciente para que ele se sinta seguro em relação ao tratamento, fazendo com que ele tenha a convicção que é uma peça fundamental. Profissional e paciente motivados, pode juntos chegar ao sucesso do tratamento.
Análise das principais complicações em pacientes no pós-operatório de fratura de tornozelo: uma revisão
Authors: De Carvalho Cainã Durans , Dos Santos Filho Douglas Terra , Borges João Victor Correa , Vieira Bruna Mirelly Simões , De Oliveira Thompson
Published: January 2024

A articulação do tornozelo possui estabilidade específica, além de estarem relacionadas ao suporte de cargas. As fraturas de tornozelo geralmente acometem pacientes com maiores valores de índice de massa corporal, idosos e aqueles com alguma comorbidade específica, como osteoporose. O tratamento cirúrgico para fratura de tornozelo, assim como cirurgias no geral, pode evoluir com complicações pós-operatórias. O presente trabalho busca analisar a epidemiologia das complicações após o tratamento cirúrgico de pacientes com fratura de tornozelo. Trata-se de um estudo observacional e transversal caracterizado como uma revisão bibliográfica. As complicações tardias, como artrose pós-traumática, foram mais comuns em fraturas de alta energia, especialmente as do tálus. As complicações dependem dos grupos de pacientes e das lesões, sendo que as mais frequentes foram Infecção de Ferida Operatória, Pseudoartrose, Trombose Venosa Profunda, Falência do material de síntese e Síndrome compartimental (minoria dos casos). Segundo análise dos estudos, conclui-se que as fraturas de tornozelo acometem principalmente pacientes entre 40 e 50 anos, sendo o principal mecanismo de trauma a entorse decorrente da queda da própria altura, sendo a fratura exposta constatada em 28% dos casos. De acordo com a análise também se constatou que as principais complicações foram infecção de ferida operatória, pseudoartrose, trombose venosa profunda e falência do material de síntese.
Avanços em cirurgia cardíaca minimamente invasiva: uma análise crítica das inovações em técnicas endovasculares e resultados clínicos
Authors: Moura Francisco Maximiano Nunes , De Araújo Atílio Fontinele Castro , Ximenes Eloide de Sousa Duarte , Barbosa Emanuelle Sales , De Alcântara João Pedro , Da Silva Marcia Freitas Lima Castro , Pinto Marco Antônio França , Almeida Priscila Nascimento de Barros , Costa Rosângela Maria Monteiro , Araújo Victoria Souza
Published: January 2024

Este artigo apresenta uma revisão meticulosa e detalhada dos avanços em cirurgia cardíaca minimamente invasiva, focando particularmente nas técnicas endovasculares, que se destacam como um marco na evolução da cardiologia e cirurgia vascular. Examinando uma série de estudos recentes, exploramos como essas inovações revolucionárias estão remodelando o campo da cirurgia cardíaca. A adoção dessas técnicas endovasculares tem sido associada a um declínio significativo no trauma cirúrgico, evidenciando uma mudança na abordagem de tratamento de doenças cardíacas. Com as técnicas endovasculares, os pacientes agora têm acesso a procedimentos que não só reduzem o tempo de recuperação, mas também diminuem drasticamente as complicações pós-operatórias. Essa transformação é fundamental para melhorar a eficiência dos cuidados de saúde e a qualidade de vida dos pacientes após a cirurgia.