bluuebunny/crossref_metadata_2025 huggingface dataset:
Biogas Production from Excess Sludge Oxidized with Peracetic Acid (PAA)
Authors: Zawieja Iwona , Worwąg Małgorzata
Published: June 2021

Human functioning related to living and economic activity involves generating an increasing amount of sewage and sludge, which needs to be subjected to advanced processes of treatment, neutralization, and management. The deterioration in the susceptibility of excess sludge to biochemical decomposition observed under anaerobic conditions leads to the development and application of highly effective methods of wastewater treatment based on the removal of biogenic compounds using activated sludge, with a high degree of sludge thickening obtained in mechanical facilities. The concentration of volatile fatty acids, being an important intermediate product of anaerobic stabilization, directly determines biogas production efficiency. This study aimed to determine the effect of chemical disintegration with peracetic acid on biogas production efficiency using methane fermentation of pretreated sludge. Intensification of the hydrolysis phase is an important determinant of the efficiency of biochemical sludge decomposition under anaerobic conditions. The association of excess sludge oxidation, initiated by peracetic acid with biological hydrolysis, which is the first phase of methane fermentation, led to an increase in sludge digestion degree and biogas production efficiency. The compound of STERIDIAL W-10, which is an aqueous solution of 10% peracetic acid, 10% acetic acid, and 8% hydrogen peroxide, was used. The disintegration of excess sludge with a reactant dose of 3.0 mL of STERIDIAL W-10/L yielded a specific biogas production of 0.52 L/g VSS and a 74% degree of sludge digestion.
Understanding the Environmental Study Life Cycle in the United States Hydropower Licensing and Federal Authorization Process
Authors: Aldrovandi Matthew S. P. , Parish Esther S. , Pracheil Brenda M.
Published: June 2021

We analyzed United States Federal Energy Regulatory Commission (FERC) documents prepared for 29 recently licensed hydropower projects and created two novel datasets to improve understanding of the environmental study life cycle, defined here as the process that begins with an environmental study being requested by a hydropower stakeholder or regulator, and ends with the study either being rejected or approved/conducted. Our two datasets consisted of summaries of information taken from (1), study determination letters prepared by FERC for 23 projects that were using the integrated licensing process, and (2), environmental study submittals and issuances tracked and attributed to seven projects using the FERC record. Our objective was to use the two resulting environmental life cycle datasets to understand which types of environmental studies are approved, rejected, and implemented during FERC licensing, and how consistently those types of studies are required across multiple hydropower projects. We matched the requested studies to a set of 61 river function indicators in eight categories and found that studies related to the category of biota and biodiversity were requested most often across all 29 projects. Within that category, studies related to river function indicators of presence, absence, detection of species and habitat/critical habitat were the most important to stakeholders, based on the relative number of studies requested. The study approval, rejection, and request rates were similar within each dataset, although the 23 projects with study determination letters had many rejected studies, whereas the dataset created from the seven projects had very few rejected studies.
Does Investor Sentiment Affect Clean Energy Stock? Evidence from TVP-VAR-Based Connectedness Approach
Authors: Liu Tiantian , Hamori Shigeyuki
Published: June 2021

We investigated the connectedness of the returns and volatility of clean energy stock, technology stock, crude oil, natural gas, and investor sentiment based on the time-varying parameter vector autoregressive (TVP-VAR) connectedness approach. The empirical results indicate that the average total connectedness is higher in the volatility system than in the return system. The investor sentiment has a weak impact on clean energy stock. Our results show that the dynamic total connectedness across assets in the system varies with time. Furthermore, the dynamic total connectedness increases significantly during financial turmoil. Dynamic total volatility connectedness is more sensitive to financial turmoil. By comparing the connectedness estimated by the TVP-VAR model with the rolling-window VAR model, we find the dynamic total return connectedness of the TVP-VAR model is similar to the estimated results of a 200 day rolling-window VAR model.
Synergistic Modes and Enhanced Oil Recovery Mechanism of CO2 Synergistic Huff and Puff
Authors: Hou Ganggang , Ma Xiaoli , Zhao Wenyue , Diwu Pengxiang , Liu Tongjing , Hou Jirui
Published: June 2021

With the gradual declining of oil increment performance of CO2 huff-and-puff wells, the overall oil exchange rate shows a downward tendency. In this regard, CO2 synergistic huff-and-puff technologies have been proposed to maintain the excellent effect and extend the technical life of such wells. However, there is no specific research on the mechanism and synergistic mode of CO2 huff and puff in horizontal wells. This study aims to establish the synergistic mode and determine the adaptability and acting mechanism of CO2 synergistic huff and puff. Three synergistic huff-and-puff modes are proposed based on the peculiarity of the fault-block reservoir’s small oil-bearing area and broken geological structure. We establish three typical CO2 synergistic huff-and-puff models and analyze the influence of different geological and development factors on the huff-and-puff performance with numerical simulation. Each factor’s sensitivity is clarified, and the enhanced oil recovery (EOR) mechanism of CO2 synergistic huff and puff is proposed. The sensitivity evaluation results show that the reservoir rhythm, inter-well passage, well spacing, high-position well liquid production rate, and middle-well liquid production rate are extremely sensitive factors; the stratum dip and injection volume allocation scheme are sensitive factors; and the relationship with structural isobaths is insensitive. The EOR mechanism of synergistic huff and puff includes gravity differentiation, supplementary formation energy, CO2 forming foam flooding, and coupling effect of production rate and oil reservoirs. The implementation conditions of the two-well cooperative stimulation mode are the simplest. The two-well model is suitable for thick oil layers with a positive rhythm and large formation dip. The single-well mode requires no channeling between the wells, and the multi-well mode requires multi-well rows and can control the intermediate well’s fluid production rate. Field application at C2X1 block shows a good performance with a total oil increment of 1280 t and an average water-cut reduction of 57.7%.
A Mixed Methods Exploration of Surf Therapy Piloted for Youth Well-Being in Post-Conflict Sierra Leone
Authors: Marshall Jamie , Kamuskay Sallu , Samai Michaella Margaedah , Marah Isha , Tonkara Fanta , Conteh Josephine , Keita Sullayman , Jalloh Oullematu , Missalie Mohamed , Bangura Mohamed , Messeh-Leone Olufemi , Leone Messeh , Ferrier Brendon , Martindale Russell
Published: June 2021

Young people in post-conflict and post-epidemic contexts such as Sierra Leone face a range of mental health challenges as part of their daily life. An innovative approach to Sport for Development that could offer support to youth mental health is surf therapy. This research used an uncontrolled mixed methods approach to explore surf therapy pilots run by five youth-focused and community development organizations around Freetown. Four sites provided useable pre/post data using the Stirling Children’s Well-Being Scale (n = 58, average age = 12.9). Three sites were associated with significant (p < 0.017) large effects (r = 0.65–0.84) on participant well-being. One site was associated with a non-significant (p < 0.380) small negative effect (r = −0.22). A synthesis of qualitative data within the five evaluations triangulated with quantitative findings and provided important context in terms of challenges to service delivery. This included low attendance as a plausible mediator for why one site saw very different results than other sites. Combined, these processes highlight the need for future research exploring possible dose-response relationships in surf therapy. This study also provides a foundation for more rigorous research in the future. These promising findings support continued and optimized delivery of surf therapy in Sierra Leone to support youth mental health.
Environmental Preferences and Concerns of Recreational Road Runners
Authors: Schuurman Nadine , Rosenkrantz Leah , Lear Scott A.
Published: June 2021

Recreational road running is growing in popularity and has been linked to numerous mental and physical health benefits. However, we know little about what environmental preferences or concerns runners have regarding participation in the sport, and whether differences exist across age and gender. We conducted a cross-sectional survey on recreational road runners to investigate the type of built and natural environments road runners prefer, as well as the safety and health concerns that may affect runners’ choice of environment. Responses were analyzed by age and gender. A total of 1228 road runners responded to the survey; 59.6% of respondents were women and 32.1% of respondents were men. Most respondents preferred to run on asphalt or sidewalk surfaces, and preferred well-lit, tree-lined routes. Major concerns for both men and women include animals and dangerous road conditions. Men and women differed significantly in their responses to the importance of running around others and their primary concerns while running. Results of this study serve to deepen our understanding of recreational road runners’ environmental preferences and concerns, providing valuable information for public health officials and city planners alike. This information must be considered if we are to continue to encourage uptake of running as a sport and reap its health effects.
Validation of the Emotional Literacy Program in Croatian Elementary Schools
Authors: Mohorić Tamara , Takšić Vladimir , Ćosić Pilepić Ana
Published: June 2021

Emotional Literacy (EL) is a well-designed, field-tested curriculum that enhances social, emotional, and academic learning. A total of 565 students, 53% female, from 17 elementary schools, participated in the study. Approximately half of the students participated in the eight-week-long EL program, while the other half was in control conditions. Both the experimental and control group fulfilled the same set of trait and ability emotional intelligence measures in three timepoints: pre-, immediately after, and six months after the program. The effect of the EL program was different for girls and boys at different measurement points. Boys placed in experimental group improved their scores at both post-treatment measurements, meaning that they rated themselves and felt more emotionally competent after being a part of the EL program. Emotional understanding improved consistently with time, measured with both the Vocabulary of Emotions Test (VET) and Test of Emotional Understanding (TEU), regardless of the participation in the EL program. The effect of maturation was slightly more visible in girls, and girls had consistently better scores on the VET and TEU tests than boys. The feedback from school psychologists working with children was positive; they agreed that the children responded well to the activities and willingly participated.
The Role of Adolescents’ Personal and Social Resources in Achieving Desired Emotional and Behavioral Outcomes during an Anxiety-Provoking Pandemic Outbreak
Authors: Bukchin-Peles Shira , Ronen Tammie
Published: June 2021

Considering adolescents’ developmentally driven stressors and social needs, they may be particularly vulnerable to the anxiety associated with the public health and economic crises due to the COVID-19 pandemic. Furthermore, they may have difficulty following the mandated contagion prevention directives. The current study focused on the role of adolescents’ positive personal resources (self-control, hope) and environmental resources (peer support) in two desired outcomes during the COVID-19 outbreak: wellbeing (i.e., maintaining/increasing positivity ratio) and contagion prevention behaviors (i.e., increasing handwashing). Path analysis was conducted using online survey data collected from a representative sample of 651 Israeli adolescents (ages 13–17). Positive resources were found to be both positively intercorrelated and negatively correlated with pandemic-related anxiety and positively with increased handwashing. Self-control correlated positively with social support, which, in turn, correlated positively with the positivity ratio (i.e., more positive than negative affects) and pandemic-related anxiety. Self-control and pandemic-related anxiety both correlated positively with increased prevention behavior. This study highlights the vital role of positive resources in achieving desired psychological and behavioral outcomes for adolescents during the anxiety-provoking pandemic. Beyond its theoretical innovation, this study offers practical value by focusing on malleable variables that could be the focus of dedicated interventions.
Video-Based Communication and Its Association with Loneliness, Mental Health and Quality of Life among Older People during the COVID-19 Outbreak
Authors: Bonsaksen Tore , Thygesen Hilde , Leung Janni , Ruffolo Mary , Schoultz Mariyana , Price Daicia , Østertun Geirdal Amy
Published: June 2021

The aim of the study was to examine the use of video-based communication and its association with loneliness, mental health and quality of life in older adults (60–69 years versus 70+ years) during the COVID-19 pandemic. A cross-sectional online survey was conducted in Norway, UK, USA and Australia during April/May 2020, and 836 participants in the relevant age groups were included in the analysis. Multiple regression analyses were conducted to examine associations between the use of video-based communication tools and loneliness, mental health and quality of life within age groups, while adjusting by sociodemographic variables. Video-based communication tools were found to be more often used among participants aged 60–69 years (60.1%), compared to participants aged 70 or above (51.8%, p < 0.05). Adjusting for all variables, the use of video-based communication was associated with less loneliness (β = −0.12, p < 0.01) and higher quality of life (β = 0.14, p < 0.01) among participants aged 60–69 years, while no associations were observed for participants in the oldest age group. The use of video-based communication tools was therefore associated with favorable psychological outcomes among participants in their sixties, but not among participants in the oldest age group. The study results support the notion that age may influence the association between the use of video-based communication tools and psychological outcomes amongst older people.
Sources of Sleep Disturbances and Psychological Strain for Hospital Staff Working during the COVID-19 Pandemic
Authors: Abdoli Nasrin , Farnia Vahid , Jahangiri Somayeh , Radmehr Farnaz , Alikhani Mostafa , Abdoli Pegah , Davarinejad Omran , Dürsteler Kenneth M. , Brühl Annette Beatrix , Sadeghi-Bahmani Dena , Brand Serge
Published: June 2021

Hospital staff members reported increased stress-related workload when caring for inpatients with COVID-19 (“frontline hospital staff members”). Here, we tested if depression, anxiety, and stress were associated with poor sleep and lower general health, and if social support mediated these associations. Furthermore, we compared current insomnia scores and general health scores with normative data. A total of 321 full-time frontline hospital staff members (mean age: 36.86; 58% females) took part in the study during the COVID-19 pandemic. They completed a series of questionnaires covering demographic and work-related information, symptoms of depression, anxiety, stress, social support, self-efficacy, and symptoms of insomnia and general health. Higher symptoms of depression, anxiety, and stress were associated with higher symptoms of insomnia and lower general health. Higher scores of depression, anxiety, and stress directly predicted higher insomnia scores and lower general health scores, while the indirect effect of social support was modest. Compared to normative data, full-time frontline hospital staff members had a 3.14 higher chance to complain about insomnia and a significantly lower general health. Symptoms of insomnia and general health were unrelated to age, job experience, educational level, and gender. Given this background, it appears that the working context had a lower impact on individuals’ well-being compared to individual characteristics.
Factor Structure of the Edinburgh Postnatal Depression Scale in a Sample of Postpartum Slovak Women
Authors: Škodová Zuzana , Bánovčinová Ľubica , Urbanová Eva , Grendár Marián , Bašková Martina
Published: June 2021

Background: Postpartum depression has a negative impact on quality of life. The aim of this study was to examine the factor structure and psychometric properties of the Slovak version of the Edinburgh Postnatal Depression Scale (EPDS). Methods: A paper and pencil version of the 10-item EPDS questionnaire was administered personally to 577 women at baseline during their stay in hospital on the second to fourth day postpartum (age, 30.6 ± 4.9 years; 73.5% vaginal births vs. 26.5% operative births; 59.4% primiparas). A total of 198 women participated in the online follow-up 6–8 weeks postpartum (questionnaire sent via e-mail). Results: The Slovak version of the EPDS had Cronbach’s coefficients of 0.84 and 0.88 at baseline (T1) and follow-up, respectively. The three-dimensional model of the scale offered good fit for both the baseline (χ2(df = 28) = 1339.38, p < 0.001; CFI = 0.99, RMSEA = 0.02, and TLI = 0.99) and follow-up (χ2(df = 45) = 908.06, p < 0.001, CFI = 0.93, RMSEA = 0.09, and TL = 0.90). A risk of major depression (EPDS score ≥ 13) was identified in 6.1% in T1 and 11.6% in the follow-up. Elevated levels of depression symptoms (EPDS score ≥ 10) were identified in 16.7% and 22.7% of the respondents at baseline and follow-up, respectively. Conclusions: The Slovak translation of the EPDS showed good consistency, convergent validity, and model characteristics. The routine use of EPDS can contribute to improving the quality of postnatal health care.
Selective Inhibitory Control in Middle Childhood
Authors: Rincón-Pérez Irene , Sánchez-Carmona Alberto J. , Arroyo-Lozano Susana , García-Rubio Carlos , Hinojosa José Antonio , Fernández-Jaén Alberto , López-Martín Sara , Albert Jacobo
Published: June 2021

The main aim of this study was to investigate the development of selective inhibitory control in middle childhood, a critical period for the maturation of inhibition-related processes. To this end, 64 children aged 6–7 and 56 children aged 10–11 performed a stimulus-selective stop-signal task, which allowed us to estimate not only the efficiency of response inhibition (the stop-signal reaction time or SSRT), but also the strategy adopted by participants to achieve task demands. We found that the adoption of a non-selective (global) strategy characterized by stopping indiscriminately to all stimuli decreased in older children, so that most of them were able to interrupt their ongoing responses selectively at the end of middle childhood. Moreover, compared to younger children, older children were more efficient in their ability to cancel an initiated response (indexed by a shorter SSRT), regardless of which strategy they used. Additionally, we found improvements in other forms of impulsivity, such as the control of premature responding (waiting impulsivity), and attentional-related processes, such as intra-individual variability and distractibility. The present results suggest that middle childhood represents a milestone in the development of crucial aspects of inhibitory control, including selective stopping.
A Descriptive Analysis of Transitions from Smoking to Electronic Nicotine Delivery System (ENDS) Use: A Daily Diary Investigation
Authors: Conner Tamlin S. , Zeng Jiaxu , Blank Mei-Ling , He Vicky , Hoek Janet
Published: June 2021

Objectives: We aimed to examine patterns in smoking and electronic nicotine delivery system (ENDS) use over an extended period of time (up to 20 weeks) in people who smoked and who had never previously made a successful quit attempt using an ENDS. Design and setting: We conducted a longitudinal mixed-methods study in Dunedin, New Zealand, during 2018 and 2019. Participants: Purposively selected participants (N = 45; age (≥18 years), gender, ethnicities, cigarettes/day) who wished to quit smoking. Interventions: Participants were provided with a second-generation ENDS device (vape pen or starter “tank” device) at the start of their quit attempt, and asked to complete smartphone-based daily diary surveys assessing smoking and ENDS use. Outcome measures: Sunburst plots and a sequence plot were used to describe weekly and daily patterns of smoking and ENDS use (smoking only, ENDS use only, dual use, abstinent). Results: The most frequently reported movements among participants, classified according to their study week behaviour, occurred between dual use and exclusive ENDS use (and vice versa). A smaller group reported moving from dual use to exclusive smoking (and often back to dual use), and a small number reported moving between abstinence and different ENDS and smoked tobacco usage behaviours. Data visualisations focussing on those participants who had provided data during each of weeks 9–12 indicate that only a minority reported sustained dual use; instead, most participants indicated varied smoked tobacco and ENDS use, which included periods of dual use. Conclusions: The considerable variety observed within and between study participants suggests that high variability is typical rather than exceptional. Transitions from smoking to ENDS use may involve considerable periods of dual use, which is likely to be dynamic and potentially sustained over several months.
Estimating Need for Glasses and Hearing Aids in The Gambia: Results from a National Survey and Comparison of Clinical Impairment and Self-Report Assessment Approaches
Authors: Boggs Dorothy , Hydara Abba , Faal Yaka , Okoh John Atta , Olaniyan Segun Isaac , Sanneh Haruna , Ngett Abdoulie , Bah Isatou , Aleser Mildred , Denis Erima , McCormick Ian , Bright Tess , Bell Suzannah , Kim Minjung , Foster Allen , Kuper Hannah , Burton Matthew J. , Mactaggart Islay , Polack Sarah
Published: June 2021

Few estimates are available of the need for assistive devices (ADs) in African settings. This study aimed to estimate population-level need for glasses and hearing aids in The Gambia based on (1) clinical impairment assessment, and (2) self-reported AD awareness, and explore the relationship between the two methods. The Gambia 2019 National Eye Health Survey is a nationally representative population-based sample of 9188 adults aged 35+ years. Participants underwent standardised clinical vision assessments including the need for glasses (distance and near). Approximately 25% of the sample underwent clinical assessment of hearing and hearing aid need. Data were also collected on self-reported awareness, need and access barriers to vision and hearing ADs. Overall, 5.6% of the study population needed distance glasses (95% CI 5.0–6.3), 45.9% (95% CI 44.2–47.5) needed near glasses and 25.5% (95% CI 22.2–29.2) needed hearing aids. Coverage for each AD was very low (<4%). The agreement between self-report and clinical impairment assessment for AD need was poor. In conclusion, there is high prevalence and very low coverage for distance glasses, near glasses and hearing aids in The Gambia. Self-report measures alone will not provide an accurate estimate of AD need.
Potential Improvement in Rehabilitation Quality of 2019 Novel Coronavirus by Isometric Training System; Is There “Muscle-Lung Cross-Talk”?
Authors: Nobari Hadi , Fashi Mohamad , Eskandari Arezoo , Pérez-Gómez Jorge , Suzuki Katsuhiko
Published: June 2021

The novel Coronavirus Disease 2019 (COVID-19) crisis is now present in more than 200 countries. It started in December 2019 and has, so far, led to more than 149, 470,968 cases, 3,152,121 deaths, and 127,133,013 survivors recovered by 28 April 2021. COVID-19 has a high morbidity, and mortality of 2%, on average, whereas most people are treated after a period of time. Some people who recover from COVID-19 are left with 20 to 30% decreased lung function. In this context, exercise focused on skeletal muscle with minimal lung involvement could potentially play an important role. Regular exercise protects against diseases associated with chronic low-grade systemic inflammation. This long-term effect of exercise may be ascribed to the anti-inflammatory response elicited by an acute bout of exercise, which is partly mediated by muscle-derived myokines. The isometric training system seems to have this feature, because this system is involved with the skeletal muscle as the target tissue. However, no studies have examined the effect of exercise on the treatment and recovery of COVID-19, and, more importantly, “muscle–lung cross-talk” as a mechanism for COVID-19 treatment. It is suggested that this theoretical construct be examined by researchers.
Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine Upregulation in Multiple Organs of Lipopolysaccharide-Induced Endotoxemic Mice via Reducing the Interaction between β-Catenin and NF-κB
Authors: Jang Jaewoong , Song Jaewon , Sim Inae , Kwon Young V. , Yoon Yoosik
Published: June 2021

Sepsis is characterized by multiple-organ dysfunction caused by the dysregulated host response to infection. Until now, however, the role of the Wnt signaling has not been fully characterized in multiple organs during sepsis. This study assessed the suppressive effect of a Wnt signaling inhibitor, Wnt-C59, in the kidney, lung, and liver of lipopolysaccharide-induced endotoxemic mice, serving as an animal model of sepsis. We found that Wnt-C59 elevated the survival rate of these mice and decreased their plasma levels of proinflammatory cytokines and organ-damage biomarkers, such as BUN, ALT, and AST. The Wnt/β-catenin and NF-κB pathways were stimulated and proinflammatory cytokines were upregulated in the kidney, lung, and liver of endotoxemic mice. Wnt-C59, as a Wnt signaling inhibitor, inhibited the Wnt/β-catenin pathway, and its interaction with the NF-κB pathway, which resulted in the inhibition of NF-κB activity and proinflammatory cytokine expression. In multiple organs of endotoxemic mice, Wnt-C59 significantly reduced the β-catenin level and interaction with NF-κB. Our findings suggest that the anti-endotoxemic effect of Wnt-C59 is mediated via reducing the interaction between β-catenin and NF-κB, consequently suppressing the associated cytokine upregulation in multiple organs. Thus, Wnt-C59 may be useful for the suppression of the multiple-organ dysfunction during sepsis.
S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity
Authors: Zaręba-Kozioł Monika , Bartkowiak-Kaczmarek Anna , Roszkowska Matylda , Bijata Krystian , Figiel Izabela , Halder Anup Kumar , Kamińska Paulina , Müller Franziska E. , Basu Subhadip , Zhang Weiqi , Ponimaskin Evgeni , Włodarczyk Jakub
Published: June 2021

Although sex differences in the brain are prevalent, the knowledge about mechanisms underlying sex-related effects on normal and pathological brain functioning is rather poor. It is known that female and male brains differ in size and connectivity. Moreover, those differences are related to neuronal morphology, synaptic plasticity, and molecular signaling pathways. Among different processes assuring proper synapse functions are posttranslational modifications, and among them, S-palmitoylation (S-PALM) emerges as a crucial mechanism regulating synaptic integrity. Protein S-PALM is governed by a family of palmitoyl acyltransferases, also known as DHHC proteins. Here we focused on the sex-related functional importance of DHHC7 acyltransferase because of its S-PALM action over different synaptic proteins as well as sex steroid receptors. Using the mass spectrometry-based PANIMoni method, we identified sex-dependent differences in the S-PALM of synaptic proteins potentially involved in the regulation of membrane excitability and synaptic transmission as well as in the signaling of proteins involved in the structural plasticity of dendritic spines. To determine a mechanistic source for obtained sex-dependent changes in protein S-PALM, we analyzed synaptoneurosomes isolated from DHHC7-/- (DHHC7KO) female and male mice. Our data showed sex-dependent action of DHHC7 acyltransferase. Furthermore, we revealed that different S-PALM proteins control the same biological processes in male and female synapses.
Uremic Toxins and Frailty in Patients with Chronic Kidney Disease: A Molecular Insight
Authors: Chao Chia-Ter , Lin Shih-Hua
Published: June 2021

The accumulation of uremic toxins (UTs) is a prototypical manifestation of uremic milieu that follows renal function decline (chronic kidney disease, CKD). Frailty as a potential outcome-relevant indicator is also prevalent in CKD. The intertwined relationship between uremic toxins, including small/large solutes (phosphate, asymmetric dimethylarginine) and protein-bound ones like indoxyl sulfate (IS) and p-cresyl sulfate (pCS), and frailty pathogenesis has been documented recently. Uremic toxins were shown in vitro and in vivo to induce noxious effects on many organ systems and likely influenced frailty development through their effects on multiple preceding events and companions of frailty, such as sarcopenia/muscle wasting, cognitive impairment/cognitive frailty, osteoporosis/osteodystrophy, vascular calcification, and cardiopulmonary deconditioning. These organ-specific effects may be mediated through different molecular mechanisms or signal pathways such as peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), mitogen-activated protein kinase (MAPK) signaling, aryl hydrocarbon receptor (AhR)/nuclear factor-κB (NF-κB), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), Runt-related transcription factor 2 (RUNX2), bone morphogenic protein 2 (BMP2), osterix, Notch signaling, autophagy effectors, microRNAs, and reactive oxygen species induction. Anecdotal clinical studies also suggest that frailty may further accelerate renal function decline, thereby augmenting the accumulation of UTs in affected individuals. Judging from these threads of evidence, management strategies aiming for uremic toxin reduction may be a promising approach for frailty amelioration in patients with CKD. Uremic toxin lowering strategies may bear the potential of improving patients’ outcomes and restoring their quality of life, through frailty attenuation. Pathogenic molecule-targeted therapeutics potentially disconnect the association between uremic toxins and frailty, additionally serving as an outcome-modifying approach in the future.
Reusing Jet Grouting Waste as Filler for Road Asphalt Mixtures of Base Layers
Authors: Russo Francesca , Veropalumbo Rosa , Biancardo Salvatore Antonio , Oreto Cristina , Scherillo Fabio , Viscione Nunzio
Published: June 2021

Secondary raw materials consist of production waste or material resulting from recycling processes, currently in large quantities, which can be injected back into the economic system as new raw materials. This study proposes jet grouting waste (JGW) as filler for hot and cold asphalt mixtures applied as base layers of road pavements and investigates the physical and mechanical properties. JGW is derived from soil consolidation performed during underground roadway tunnel construction. The research compares three asphalt mixtures: (a) hot mixture containing limestone aggregate-filler (HMA), (b) HMA containing JGW (HMAJ), (c) cold recycled asphalt mixture containing JGW (CRAJ). Leaching tests of JGW and reclaimed asphalt pavement (RAP) were conducted; the best configurations of the three mixtures were determined by using the volumetric method through gyratory compaction. Three mastics with filler-to-binder ratios reflecting those of the asphalt mixtures were investigated through delta ring and ball test and frequency sweep test at 0.05% stress by using a dynamic shear rheometer. The morphology of each mixture was further investigated by scanning electron microscopy. The results showed that CRAJ with 28 days of curing time reached the indirect tensile strength (ITS) of HMA (0.73 MPa) within 14 days and, among all studied mixtures, returned the lowest cumulative strain, which was on average 30% lower than that of HMA and HMAJ. The results of this study have shown that the cold alternative mixture, CRAJ, promotes the reuse of two types of waste, RAP and JGW, as it fully meets the reference Italian Technical Standard and ensures good mixture performance in addition to conserving natural resources.
Prediction Model of Concrete Initial Setting Time Based on Stepwise Regression Analysis
Authors: Liu Wei-Jia , Niu Xu-Jing , Yang Ning , Tan Yao-Shen , Qiao Yu , Liu Chun-Feng , Wu Kun , Li Qing-Bin , Hu Yu
Published: June 2021

Mass concrete is usually poured in layers. To ensure the interlayer bonding quality of concrete, the lower layer should be kept in a plastic state before the upper layer is added. Ultimately, it will lead to the prediction of concrete setting time as a critical task in concrete pouring. In this experiment, the setting time of concrete in laboratory and field environments was investigated. The equivalent age of concrete at the initial setting was also analyzed based on the maturity theory. Meanwhile, factors affecting the setting time in the field environment were studied by means of multiple stepwise regression analysis. Besides, the interlayer splitting tensile strength of concrete subjected to different temperatures and wind speeds was determined. The results of laboratory tests show that both setting time and interlayer splitting tensile strength of concrete decrease significantly with the increase of air temperature and wind speed. In addition, the equivalent age of concrete at initial setting remains the same when subjected to different temperatures, while it decreases obviously with the increase of wind speed. In the field environment, the equivalent age of concrete at initial setting is greatly different, which is related to the variability of relative humidity and wind speed. The average air temperature and maximum wind speed are the main factors affecting the initial setting time of concrete. Furthermore, a prediction model is established based on the stepwise regression analysis results, which can predict the actual setting state in real-time, and hence controlling the interlayer bonding quality of dam concrete.
Ultrasonically Processed WSe2 Nanosheets Blended Bulk Heterojunction Active Layer for High-Performance Polymer Solar Cells and X-ray Detectors
Authors: Liu Hailiang , Hussain Sajjad , Lee Jehoon , Vikraman Dhanasekaran , Kang Jungwon
Published: June 2021

Two-dimensional (2D) tungsten diselenide (WSe2) has attracted considerable attention in the field of photovoltaic devices owing to its excellent structure and photoelectric properties, such as ordered 2D network structure, high electrical conductivity, and high mobility. For this test, we firstly prepared different sizes (NS1–NS3) of WSe2 nanosheets (NSs) through the ultrasonication method and characterized their structures using the field emission scanning electron microscope (FE-SEM), Raman spectroscopy, and X-ray powder diffraction. Moreover, we investigated the photovoltaic performance of polymer solar cells based on 5,7-Bis(2-ethylhexyl)benzo[1,2-c:4,5-c′]dithiophene-4,8-dione(PBDB-T):(6,6)-phenyl-C71 butyric acid methyl ester (PCBM) with different WSe2 NSs as the active layer. The fabricated PBDB-T:PCBM active layer with the addition of NS2 WSe2 NSs (1.5 wt%) exhibited an improved power conversion efficiency (PCE) of 9.2%, which is higher than the pure and NS1 and NS3 WSe2 blended active layer-encompassing devices. The improved PCE is attributed to the synergic enhancement of exciton dissociation and an improvement in the charge mobility through the modified active layer for polymer solar cells. Furthermore, the highest sensitivity of 2.97 mA/Gy·cm2 was achieved for the NS2 WSe2 NSs blended active layer detected by X-ray exposure over the pure polymer, and with the NS1 and NS2 WSe2 blended active layer. These results led to the use of transition metal dichalcogenide materials in polymer solar cells and X-ray detectors.
Debunking the Concept of Dentinal Tubule Penetration of Endodontic Sealers: Sealer Staining with Rhodamine B Fluorescent Dye Is an Inadequate Method
Authors: Donnermeyer David , Schmidt Sina , Rohrbach Arno , Berlandi Johannes , Bürklein Sebastian , Schäfer Edgar
Published: June 2021

The aim of this study was to investigate the suitability of rhodamine B dye staining of an epoxy resin sealer (AH Plus) and calcium-silicate-based sealers (Total Fill BC Sealer, BioRoot RCS) to represent the penetration depth of the sealers into dentinal tubules after root canal obturation. In a three-step process, (1) leaching of rhodamine B from sealers into a buffer solution, (2) passive penetration of leached rhodamine B into dentinal tubules, and (3) conformity of rhodamine B penetration assessed by confocal laser scanning microscopy (CLSM), and sealer penetration assessed by scanning electron microscopy (SEM), in root-canal-filled teeth, were evaluated. Rhodamine B dye massively leached out of Total Fill BC Sealer and BioRoot RCS into the phosphate-buffered saline (PBS). A pinkish coloration of AH Plus was found after contact with PBS. Leached rhodamine B dye passively penetrated dentinal tubules from all three sealers when placed on root dentin. No correlation was observed between sealer penetration in SEM and rhodamine B penetration in CLSM. Staining of sealers using rhodamine B is an inadequate method with which to evaluate sealer penetration depth into dentinal tubules, as it overestimates the penetration of sealers into root dentin tubules.
Formulation of Ocular In Situ Gels with Lithuanian Royal Jelly and Their Biopharmaceutical Evaluation In Vitro
Authors: Perminaite Kristina , Marksa Mindaugas , Stančiauskaitė Monika , Juknius Tadas , Grigonis Aidas , Ramanauskiene Kristina
Published: June 2021

Royal jelly is a natural substance produced by worker bees that possesses a variety of biological activities, including antioxidant, anti-inflammatory, antibacterial, and protective. Although fresh royal jelly is kept at low temperatures, to increase its stability, it needs to be incorporated into pharmaceutical formulations, such as in situ gels. The aim of this study was to formulate in situ ocular gels containing Lithuanian royal jelly for topical corneal use in order to increase the retention time of the formulation on the ocular surface and bioavailability. Gels were evaluated for physicochemical characteristics (pH, rheological properties, refractive index) and in vitro drug release measuring the amount of 10-hydroxy-2-decenoic acid (10-HDA). An ocular irritation test and cell viability tests were performed using the SIRC (Statens Seruminstitut Rabbit Cornea) cell culture line. Results indicated that all the in situ gels were within an acceptable pH and refractive index range close to corneal properties. Rheology studies have shown that the gelation temperature varies between 25 and 32 °C, depending on the amount of poloxamers. The release studies have shown that the release of 10-HDA from in situ gels is more sustained than royal jelly suspension. All gel formulations were non-irritant according to the short-time exposure test (STE) using the SIRC cell culture line, and long-term cell viability studies indicated that the formulations used in small concentrations did not induce cell death. Prepared in situ gels containing royal jelly have potential for ocular drug delivery, and they may improve the bioavailability, stability of royal jelly, and formation of non-irritant ocular formulations.
Measurement and 3D Visualization of the Human Internal Heat Field by Means of Microwave Radiometry
Authors: Sidorov Igor Alexandrovich , Gudkov Alexsandr Grigorevich , Leushin Vitalij Yurievich , Gorlacheva Eugenia Nikolaevna , Novichikhin Eugenij Pavlovich , Agasieva Svetlana Victorovna
Published: June 2021

The possibility of non-invasive determination of the depth of the location and temperature of a cancer tumor in the human body by multi-frequency three-dimensional (3D) radiothermography is considered. The models describing the receiving of the human body’s own radiothermal field processes are presented. The analysis of the possibility of calculating the desired parameters based on the results of measuring antenna temperatures simultaneously in two different frequency ranges is performed. Methods of displaying on the monitor screen the three-dimensional temperature distribution of the subcutaneous layer of the human body, obtained as a result of data processing of a multi-frequency multichannel radiothermograph, are considered. The possibility of more accurate localization of hyperthermia focus caused by the presence of malignant tumors in the depth of the human body with multi-frequency volumetric radiothermography is shown. The results of the study of various methods of data interpolation for displaying the continuous intrinsic radiothermal field of the human body are presented. Examples of displaying the volumetric temperature distribution by the moving plane method based on digital models and the results of an experimental study of the thermal field of the human body and head are given.
Assessment of small water bodies Sergiev Posad district on the taxonomic diversity of green, blue-green and diatom algae
Authors: Gorbunov Alexander Viacheslavovich , Gorbunov Oleg Viacheslavovich , Kochetkov Nikita Il’ich , Nikiforov-Nikishin Dmitry Lvovich
Published: June 2021

The purpose of the study was to determine the degree of saprobity of the artificial extension of the Vytravki riverbed (left tributary of the Dubna river) in the Sergiev Posad district of the Moscow region, based on the taxonomic composition of the pelagial and littoral algal flora. For this purpose, the systematic position of algae was determined using a number of domestic and foreign sources, as well as using the electronic database AlgaeBase. The most attention was paid to common indicator types, according to the literature data. Algological samples were taken in accordance with generally accepted methods; the main part of the samples was processed immediately after collection on site, the rest of the material was fixed with a formalin solution and Prat medium for detailed study in laboratory conditions under a microscope. According to the results of the study of hydrobiological samples, the composition of algal flora in the summer-autumn period was determined. There is a large species diversity of algae, represented by most of the divisions characteristic of the Central part of Russia. The green, diatomaceous, and blue-green algae divisions were the most represented. Maximum species diversity was observed for the genera Scenedesmus (9 species) and Pediastrum (10 species). Diatoms are the second group in terms of frequency of occurrence of species that live both in standing water and in rheophilic conditions. Blue-green algae were represented by pelagic forms, with a small frequency of occurrence. Among them, the genera Anabaena (5 species) and Microcystis (3 species) are notable for their high species diversity. The algal flora of the pond was marked divisions, dinophyceae and kropotova, typical for oligotrophic and distrophic reservoirs, indicating a high quality water environment. The established hydrochemical parameters of the reservoir were normal and were similar to the reservoirs of Central Russia at the end of the growing season, which were not exposed to anthropogenic impact.
Theoretical and practical aspects of domestication of common catfish (Silurus glanis, L.)
Authors: Rozumnaya Lyubov Anatolyevna , Pronina Galina Iozepovna , Petrushin Alexander Borisovich , Shishanova Elena Ivanovna
Published: June 2021

The article discusses some aspects of the domestication of common catfish (Silurus glanis) in the conditions of cyprinid fish farms. Under the pressure of selection and directed cultivation in pond conditions of carp fish farms, changes in ethological, morphological, and physiological indicators are observed. The variability of the majority of morphological indicators and development indices (8–14%) indicates a high degree of consolidation of the resulting breeding offspring and indicates the completion of the first stage of domestication in the conditions of fish-breeding carp farms. Physiological and biochemical assessment of different age categories of catfish showed low variability of physiological indicators. it Can be assumed that the decrease in the coefficient of variability is a consequence of domestication. Studies of the immunological status have shown its optimal level, which allows us to accept the obtained indicators as indicative standards for evaluating brood flocks and their offspring. There was a significant increase in the body weight of commercial three-year-olds of the 4th breeding generation, compared with the first generation. It is established that the reproduction of catfish planted in carp summer-fallow ponds is more successful than in natural reservoirs, since ponds of this category are often small, well-warmed, which contributes to the rapid maturation of producers and the development of caviar. When growing in pond conditions for 2–3 generations, changes in behavioral reactions were noted — there was a decrease in aggressiveness and the development of conditioned reflexes to the specified food objects. The level of food availability affects the metabolism and maturation period, so along with the use of the natural feed base of the pond, it is recommended to use additional feeding and directed formation of the natural feed base.
Forecasting oceanfront shoreline position to evaluate physical vulnerability for recreational and infrastructure resilience at Cape Hatteras National Seashore
Authors: Flynn Michael , Hallac David
Published: June 2021

The Cape Hatteras National Seashore (Seashore) is located along the Outer Banks of eastern North Carolina, and is renowned for its prominent historical landmarks and world-class recreation. Seashore managers maintain hundreds of assets that support visitor use. Additionally, and primary to the mission of the National Park Service (NPS), managers steward natural and cultural resources located on public and protected lands. The portfolio of assets managed by NPS within the Seashore carries a high level of risk due to its exposure to both coastal erosion and storm surge inundation. The impacts of Hurricane Dorian demonstrated the importance of examining the physical vulnerability of the entire portfolio managed by NPS within the Seashore. The purpose of this study was to 1) evaluate the functionality of the beta forecast tool available in the Digital Shoreline Analysis System (v 5.0); and 2) explore options for using the output to assess the potential physical vulnerability of NPS assets. The study determined that using the 10- and 20-year oceanfront shoreline position forecast provides decision makers with a first order screening tool that can be used to prioritize mitigation and adaptation strategies given the unpredictable nature of tropical and extra-tropical cyclones and uncertainty associated with sea level rise.