bluuebunny/crossref_metadata_2025 huggingface dataset:
Peer Group Support Application in Overcoming Depression in the Elderly: A Narrative Review
Authors: Yuniartika Wachidah , Pandin Moses Glorino Rumambo , Yusuf Ah
Published: December 2024

Depression in the elderly is a public health problem that is often significantly undetected and untreated which can lead to increased use of health facilities and even death, social support also plays an important role in behavioral change and self-management in the elderly in dealing with depression. This review aims to explore the effectiveness of peer group support applications in overcoming depression in the elderly. The narrative review approach with the Arksey and O'Malley methodological framework and the PRISMA 2020 diagram formulates how peer group interventions can help reduce depression levels in the elderly. The articles reviewed were selected using inclusion criteria such as elderly population, focus on older adults, depression, treatment, peer group interventions, social support, and using a randomized controlled trial (RCT) design. Data sources include databases such as PubMed, ScienceDirect, Scopus, Google Scholar, Sage, Crossref, and Ebscohost with a publication year range of 2020-2024. A total of 10 articles that met the criteria were obtained through strict selection from 520 initial articles. Based on the systematic review that has been conducted, the results obtained show that there is effectiveness of peer support-based approaches in various contexts, ranging from sports, education, to Cognitive Behavioral Therapy training. Differences in results indicate the diversity of intervention designs and subject populations, but the majority of studies show significant benefits in reducing depression in the elderly, in addition to the results of the narrative review there are also benefits to the quality of life, cognitive function and mental health of the elderly.
A Survey On Automation of Local Government Services using Retrieval-Augmented Generation
Authors: M Nair Athul , George Jacob Noel , V Gopika , Krishna Rao M Vimal , S Nair Manju
Published: December 2024

The Local Self Government Department (LSGD) of Kerala provides a wide array of essential services to the public, but accessing these services can be complex and time-consuming. This ideology proposes the development of a chatbot designed to automate the basic services offered by the LSGD website, with additional features such as complaint generation and local language support. By leveraging Large Language Models (LLM) and Retrieval-Augmented Generation (RAG), the chatbot will enable users to easily access and interact with government forms, schemes, and services. This technology ensures rapid adaptation to newly introduced forms and services within the government database. The chatbot is designed to simplify access to local government functions, enhance the efficiency of complaint handling, and provide multilingual support for broader accessibility. Key features include automation of services, streamlined complaint generation, and local language integration for userfriendly interactions.
Reintroduction of Brook Lamprey (Lampetra planeri) in a Lowland Stream and Evaluation of Its Success
Authors: Schiphouwer Martijn E. , Spikmans Frank , Groen Mark , Scheepens Mark , Bruns Maarten
Published: December 2024

Brook lamprey (Lampetra planeri) became extinct in much of its former range in the south of the Netherlands. A reintroduction project from 2014 until 2018 aimed at the reestablishment of a population in the Reusel stream. Every year just over 1000 individuals (96% larvae, 4% adults) were translocated from the nearest population. Monitoring reveals that donor population was not jeopardized. The new population reproduces, larvae densities increased to >2 individuals per square meter in (sub) optimal habitat, larvae occur in different age groups and the distribution range expanded to 5 km. In 2024 the population is at the point of self-sustaining through natural reproduction. The new population judged by size, range and demographics is currently estimated to be ‘Vulnerable’, based on IUCN criteria. Due to a high probability of impact of droughts and therefore an increased extinction risk, the best available integrated estimate of population status would be ‘Endangered’. Monitoring remains essential to keep track of the development of the brook lamprey population and in steering ‘post reintroduction management’. The water system showed to be highly sensitive to progressive impacts from climate change and intensive land use. Further restoration of the watershed is extremely important to both nature and agriculture.
Effects of Light Crystal Display 3D-Printing Technology, Storage Time and Steam Sterilization on Dimensional Stability of a Photopolymer Resin for Surgical Guides: An In-Vitro Study
Authors: Pranno Nicola , Franchina Alessio , De Angelis Francesca , Bossù Maurizio , Salucci Alessandro , Brauner Edoardo , Cristalli Maria Paola , La Monaca Gerardo
Published: December 2024

Background: Implant surgical guides manufactured in-house using 3D- printing technology are widely used in clinical practice to transfer virtual planning to the operative field.
Aim: The present in-vitro study investigated the dimensional changes of 3D-surgical guides printed in-house using the Shining 3D surgical guide resin (SG01).
Materials and methods: Five test bodies, different in shapes and dimensions, were designed using a computer-aided design (CAD) software program and manufactured by the three Light Crystal Display (LCD) 3D- printers. Specific printing and post-processing parameters of SG01 resin were set to manufacture 25 test bodies from each printer. Dimensional changes of 75 samples were evaluated using a digital calliper at four different time points: immediately after printing (T0), one month after storage (T1), immediately after sterilization (T2), and one month after sterilization (T3).
Results: All test bodies showed deviations from the overall CAD reference value of 12.25 mm after printing and post-processing (T0) and following steam sterilization (T2). Similar trends were observed for the effect of storage times at T1 and T3. The AccuFab prints demonstrated better dimensional stability than the Elegoo and Zortrax samples.
Conclusions: LCD-3D printers, sterilization, and storage times influenced the dimensional stability of test bodies made with SGO1 resin.
Effect of the Position of a Phenyl Group on the Luminescent and TNP-Sensing Properties of Cationic Iridium(III) Complexes
Authors: Yang Xiaoran , Du Jiahao , Cai Rui , Liu Chun
Published: December 2024

Three cationic Ir(III) complexes 1, 2, and 3 were successfully synthesized and characterized by tuning the position of a phenyl group at the pyridyl moiety in 2-phenylpyridine. All three complexes exhibit typical aggregation-induced phosphorescence emission (AIPE) properties in CH3CN/H2O. The AIPE property was further utilized to achieve highly sensitive detection of 2,4,6-trinitrophenol (TNP) in aqueous media with low limits of detection (LOD) of 164, 176, and 331 nM, respectively. This suggests that the different positions of the phenyl group influence the effectiveness of 1, 2, and 3 in the detection of TNP. In addition, 1, 2, and 3 showed superior selectivity and anti-interference for the detection of TNP and the potential to detect TNP in practical applications. Taking 1 as an example, the changes in the luminescent lifetime and UV-Vis absorption spectra of 1 before and after the addition of TNP, indicate that the quenching process is a combination of static and dynamic quenching. Additionally, the proton nuclear magnetic resonance spectra and spectral studies show that the detection mechanism is photo-induced electron transfer (PET).
Conservation of Tiger Nut Tubers with Natural Biofilm Formulated with Thymus zygis Essential Oil
Authors: Santamarina María Pilar , Gimenez-Santamarina Silvia , Santamarina Cristina , Larran Silvina , Caselles Josefa Roselló
Published: December 2024

Cyperus esculentus L. var sativus is cultivated in Spain only in the L´Horta Nord in the Valencia region. In this country, tubers are consumed fresh to make a popular beverage in the Valencia region called “horchata de chufa” (chufa milk). This drink is considered beneficial for human health for its high nutritional value and medicinal importance in several treatments. This work evaluates the antifungal potential of the Thymus zygis essential oil against fungi found in tiger nut warehouses to preserve tubers under the best conditions. The analyzed commercial thyme es-sential oil belongs to the thymol/p-cymene/γ-terpinene chemotype. Thymol was found in larger quantities (51.34%), followed by the identified biogenetic precursors p-cymene (35.16%) and γ-terpinene (3.53%). Carvacrol also appeared, but in small quantities (3.53%). During "in vitro" tests, the T. zygis EO showed strong inhibition (98.85% to 91.81% MGI) against fungi Alternaria al-ternata, Fusarium andiyaci, Fusarium incarnatum and Fusarium oxysporum at 300 µg/mL. It totally inhibited their growth (100% MGI) at 400 µg/mL, and did so strongly (75.94%, 72.16% and 70.78%) with fungi Podospora australis, Penicillium commune and Cladosporium subuliforme, respectively. Under “in vivo” conditions, formulated as a protective biofilm, and by forcing the environmental con-ditions of temperature and humidity to the maximum for fungus F. andiyazi growth on tiger nut tubers, the created film acted as a strong protector against fungal attack.
Patients with Adult-onset Still’s Disease in Germany: A Retrospective Analysis of Clinical Characteristics and Treatment Practices Ahead of the German Recommendations
Authors: Schoenau Verena , Wendel Sarah , Henes Joerg , Feist Eugen , Baerlecken Niklas Thomas , Popp Florian , Schmidt-Haendle Matthias , Hellmich Bernhard , Kötter Ina , Andreica Ioana , Rech Jürgen
Published: December 2024

Background/Objectives: Adult-onset Still’s disease (AOSD) is an autoinflammatory disorder that can be challenging to diagnose and manage. The goal of this study was to analyze retrospective data to provide insights into the clinical presentation, disease activity, and treatment outcomes of AOSD during routine clinical care. Methods: This retrospective database analysis included adult patients (≥18 years) with a diagnosis of AOSD who had a clinical visit between January 1, 2010, and December 31, 2020. Evaluated outcomes included demographic characteristics, symptoms, disease activity, and treatment. Results: Our study included 120 patients (55.8% female) diagnosed with AOSD at ten German rheumatology centers. The mean (standard deviation [SD]) age was 51 (16) years and the mean (SD) time from diagnosis was 9 (7) years. Approximately half (55.0%) had a polycyclic disease course. The most frequent symptoms at initial diagnosis were arthralgia (87.5%) and fever (71.7%), and these symptoms continued in a substantial proportion of patients at the current visit (29.2% and 18.3%, respectively). High neutrophil and ferritin levels were also common. Mean disease activity scores improved from initial diagnosis to current visit (from 4.66 to 1.97 for the Still Activity Score). The treatments most frequently used at some point in the disease course were glucocorticoids (95.8%), interleukin (IL)-1 inhibitors (74.2%), and methotrexate (70.8%). The most common current treatments were IL-1 inhibitors (45.8%) followed by methotrexate (24.2%) and glucocorticoids (23.3%). Conclusions: Patients with AOSD seen at German rheumatology clinics show strong improvements in symptoms and disease activity from initial diagnosis, but a high burden of disease remains in some patients. Future studies will be needed to document the impact of new guidelines on treatment patterns.
A New Mortality Score in Preterm Infants: The Vasoactive Inotropic Score
Authors: Özalkaya Elif , Arifoğlu, İlker , Yarış Emre , Topçuoğlu Sevilay , Sancak Selim , Dinçer Emre , Alkan Özge , Karatekin Guner
Published: December 2024

Background: Can vasoactive inotropic score (VIS) be a new mortality score in preterm infants weighing less than 1000 grams? Method:This study was designed as a retrospective study. A total of 280 preterm infants under 1000 grams admitted to the neonatal intensive care unit over a five-year period were included in the study. For each patient, CRIB-II score and VIS were calculated, and their ability to predict mortality was compared. To predict and compare the accuracy of the scoring systems, Receiver Operating Characteristic (ROC) analysis was used, and the area under the curve (AUC) was calculated. Results:In infants who died within the first 28 days postnatally, CRIB-II Score (p=0.0001) and VISmax (p=0.0001) were higher compared to those who survived. The AUC for CRIB-II and VIS in predicting mortality were 0.86/0.81, with cutoffs of >12/>5, sensitivity 79/70, specificity 82/87, positive predictive value (PPV) 81/85, and negative predictive value 80/75, respectively. There was no statistically significant difference between the AUC values of the CRIB-II Score and VIS variables (p=0.160). Conclusion: VIS can predict mortality in very low birth weight preterm infants as accurately as the CRIB-II score.
Evaluating the Effectiveness of Commonly Used Sentiment Analysis Models for the Second Indochina War
Authors: Chakraborty Arijit
Published: December 2024

Sentiment analysis, a subfield of Natural Language Processing (NLP), is widely used to analyze public opinion, yet its application to historical and political nuanced events are unexplored. This study evaluates the effectiveness of two popular open-source sentiment analysis models—VADER, a lexicon-based approach, and DistilBERT, a transformer-based deep learning model—in analyzing texts related to a historical and politically nuanced event: The Second Indochina War, commonly known as the Vietnam War. Using a dataset categorized into Pro-Vietnamese, Pro-American, and Civilian perspectives, the models were assessed for their ability to capture emotional and ideological nuances. While VADER proved efficient for informal texts, it oversimplified complex narratives. DistilBERT captured subtle context but struggled with ideological undertones. Results highlight the challenges of applying existing sentiment models to historically significant data. The study emphasizes the need for hybrid approaches combining automated tools with human analysis to improve accuracy. Future work could expand datasets and incorporate advanced models for a deeper understanding of politically charged texts.
Improving Web Platform Performance Through Predictive Cloud Resource Management
Authors: Fujii Aya , Tanaka Hiroshi
Published: December 2024

Optimizing resource management is essential for improving the performance of web platforms in dynamic cloud environments. This paper introduces a predictive cloud resource management framework that integrates Long Short-Term Memory (LSTM) neural networks for workload forecasting with a dynamic resource scaling mechanism. The framework proactively allocates cloud resources, addressing challenges such as latency, cost inefficiency, and under-utilization. Experimental evaluations on a benchmark dataset demonstrated significant performance improvements over traditional methods. The proposed framework achieved a mean squared error (MSE) of 0.012 in workload prediction, a 28% reduction in response time, and a 23% increase in cost savings. These results highlight the effectiveness of predictive resource management in managing dynamic workloads and optimizing distributed web systems. The findings provide a scalable and cost-efficient solution, contributing to advancements in cloud-based resource management. Future work will explore hybrid models to further enhance adaptability and address real-time anomalies. This research lays a foundation for developing innovative and sustainable strategies in distributed computing environments.
Can AI-Driven Plagiarism Detection Tools Uphold Academic Integrity Without Ethical Compromises? A Comprehensive Analysis of False Positives, Contextual Misunderstandings, and Dependency Issues
Authors: Eslit Edgar
Published: December 2024

The rapid advancement of digital technologies has significantly impacted academic practices, particularly in the area of plagiarism detection. As universities and research institutions adopt tools to safeguard academic integrity, concerns arise about their effectiveness and potential limitations. This study investigates the role of automated plagiarism detection tools in higher education, examining how they influence academic practices and the detection of both traditional and AI-generated plagiarism. Despite the sophistication of tools like Turnitin, PlagScan, GPTZero, and QuillBot, the research finds that these systems often struggle with accurately interpreting context, resulting in false positives and overlooked instances of plagiarism. The study underscores the necessity of combining technology with human judgment, recognizing that such tools should be seen as supplementary rather than definitive measures of originality. Grounded in theoretical frameworks such as Technological Determinism, Actor-Network Theory (ANT), and Socio-Technical Systems Theory (STS), the research highlights the complex relationship between technology, academia, and societal expectations. Through a qualitative analysis of existing literature, the study identifies key challenges and suggests that hybrid approaches, blending technological tools with human oversight, may offer a more balanced and effective approach to plagiarism detection. The findings encourage further exploration into the ethical implications of reliance on automated systems in education and their broader impact on academic integrity.
Functional RNA-Seq Profiling of the Tumor Suppressor Gene OPCML in Ovarian Cancers: The Multifunctional, Pleiotropic Impacts of Having Three Ig Domains
Authors: Marsh Adam , Gortler Franziska , Hafizi Sassan , Gabra Hani
Published: December 2024

The IgLON Family of Tumor Suppressor Genes (TSG) impact a variety of cellular processes involved in cancer and non-cancer biology. OPCML is a member of this family and as a potent TSG it is commonly silenced in many human cancers and thus an important control point in oncogenesis and tumor growth. Here, we analyze RNA-Seq expression ratios in ovarian cancers from The Cancer Genome Atlas (TCGA) to identify gene sets that exhibit a synergistic survival difference in patients in association with loss of OPCML expression. Using enrichment analyses, we reconstruct functional associations revealing broad secondary cross-talk impacts of OPCML. These results emphasize the role of OPCML's regulation of Receptor Tyrosine Kinase (RTK) signaling pathways (PI3K/AKT and MEK/ERK) while identifying three new potential RTK transcriptomic linkages to KIT, TEK and ROS1 in ovarian cancers. In addition, we show that many other known extracellular signaling receptor ligands are also transcriptionally linked to OPCML. Considering the range of cell surface and signaling pathway impacts of OPCML evident here, we expand the understanding of OPCML's broad cellular influences and conclude that OPCML is a multi-functional, pleiotropic, Tumor Suppressor.
Exploring Narrative Ability in Greek-Speaking Children with High-Functioning ASD: Associations with Memory and Attention
Authors: Zarokanellou Vasiliki , Gryparis Alexandros , Papanikolaou Katerina
Published: December 2024

Background/Objectives: Narration is a sensitive tool for the assessment of language in children with high-functioning autism spectrum disorder (HF-ASD) since mild language deficits beyond the sentential level are not always noticeable through the administration of standardized language tests targeting the lexical or sentential level. This study investigated the narrative ability of monolingual Greek-speaking HF-ASD children in comparison to that of their typically developing (TD) peers and explored the associations between narrative variables and ADHD symptomatology, and memory skills in the participants on the autistic spectrum. Methods: Participants were 39 children aged 7 to 12 years, 19 with HF-ASD, and 20 age-matched, vocabulary-matched, and cognitively matched TD peers. Results: The two groups were similar in most microstructural and macrostructural variables, but differed significantly in syntactic complexity and subordination indices, implying that the HF-ASD group presented syntactic delay in comparison to their TD peers. HF-ASD participants showed significantly higher heterogeneity in the amount of information generated for the story’s main character in comparison to TD peers. Significant associations were observed between verbal and visual memory, and complex syntactic structures and Theory of Mind-related internal state terms. ADHD symptomatology was negatively correlated with the generation of simple and coordinated clauses. Finally, complex syntax and delayed vSTM were correlated with retelling total scores, indicating that language ability and verbal memory compensate for narrative competence in HF-ASD children. Conclusions: The findings highlight the impact that language skills, memory ability, and ADHD symptomatology have on narrative competence in children with HF-ASD.
Do What You Say – Computing Personal Values Associated with Professions Based on the Words They Use
Authors: Jha Aditya , Gloor Peter A
Published: December 2024

Members of a profession frequently show similar personality characteristics. In this research we leverage recent advances in NLP to compute personal values using a moral values framework, distinguishing between four different personas that assist in categorizing different professions by personal values: "fatherlanders" - valuing tradition and authority, "nerds" - valuing scientific achievements, "spiritualists" - valuing compassion and non-monetary achievements, and "treehuggers" - valuing sustainability and the environment. We collected 200 youtube videos and podcasts for each professional category of lawyers, academics, athletes, engineers, creatives, managers, and accountants, converting their audio to text. We also categorize these professions by team player personas into "bees" - collaborative creative team players, "ants" - competitive hard workers, and "leeches" - selfish egoists , using pre-trained models. We find distinctive personal value profiles for each of our seven professions computed from the words that members of each profession use.
Electrochemical and Optical Carbon Quantum Dots and Glassy Carbon Biosensors: A Review on Their Development and Applications in Early Cancer Detection
Authors: López Juana G. , Muñoz Mariana , Arias Valentina , García Valentina , Calvo Paulo C. , Ondo-Méndez Alejandro O. , Rodríguez-Burbano Diana C. , Fonthal Faruk
Published: December 2024

Cancer remains one of the leading causes of mortality worldwide, making early detection a critical factor in improving patient outcomes and survival rates. Developing advanced biosensors is essential for achieving early detection and accurate cancer diagnosis. This review offers a comprehensive overview of the development and application of carbon dots (CDs) and glassy carbon (GC) biosensors for early cancer detection. It covers the synthesis of CDs and GC, electrode fabrication methods, and electrochemical and optical transduction principles. The review explores various biosensors, including enzymatic and non-enzymatic, and discusses key biomarkers relevant to cancer detection. It also examines characterization techniques for electrochemical and optical biosensors, such as electrochemical impedance spectroscopy, cyclic voltammetry, UV-vis, and confocal microscopy. The findings highlight the advancements in biosensor performance, emphasizing improvements in sensitivity, selectivity, and stability, and underscore the potential of integrating different transduction methods and characterization approaches to enhance early cancer detection.
Long‐Term Exposure to Lambda‐Cyhalothrin Reveals Novel Genes Potentially Involved in Aedes aegypti Insecticide Resistance
Authors: Mejía Alejandro , Mejía-Jaramillo Ana Maria , Fernandez Geysson Javier , Granada Yurany , Lowenberger Carl , Triana-Chávez Omar
Published: December 2024

Insecticide resistance in Aedes aegypti populations hinders vector control programs. Many studies have focused on the classical mechanisms, kdr mutations, and metabolic enzymes to understand the development of insecticide resistance. In this study, we subjected a strain of Ae. aegypti to selective pressure for 13 consecutive generations to understand the development and extent of insecticide resistance. We delved into the transcriptomics of this pressured strain to gain insights into the molecular changes underlying insecticide resistance in Ae. aegypti. Our data suggest mosquito resistance is influenced by additional mechanisms that are difficult to explain using only classical mechanisms. The response by mosquitoes varies depending on the exposure time. Initially, when mosquitoes are in contact with insecticides, they modulate the expression of metabolic enzymes and gain some point mutations in the sodium channel genes. After long-time exposure, the mosquitoes respond to insecticides by expressing different proteins involved in the cuticle, energetic metabolism, and synthesis of proteases. We propose a model that includes these novel mechanisms found after prolonged insecticide exposure, which work in conjunction with established mechanisms (kdr and metabolic resistance) but have a different timeline in terms of expression and appearance.
PREVALENCE AND TRANSMISSIBILITY OF NONTUBERCULOUS MYCOBACTERIA IN HUMANS AND ANIMALS IN NOVOSIBIRSK OBLAST
Authors:   Novosibirsk Tuberculosis Research Institute, GUSELNIKOVA ELENA P.
Published: December 2024

Abstract. Introduction. Nontuberculous mycobacteria are found everywhere in the environment, including in various
ecological reservoirs among wild and domestic animals, birds, fish, in human life, in soil, dust particles, in natural
reservoirs, and in water distribution systems. Aim. To study the prevalence of various types of nontuberculous
mycobacteria in humans and farm animals in Novosibirsk Oblast and assess the correlation of the prevalence of
mycobacteriosis foci detected in medical and veterinary care systems. Materials and Methods. 219 samples of animal
biomaterial consisting of lymph nodes of cattle and pigs, cattle lungs and small intestine, and the internal organs of pigeons from the farms of Novosibirsk Oblast were analyzed. The study included 50 cultures of nontuberculous
mycobacteria obtained from pathomorphological material of animals, 54 samples from environmental objects, such
water from various sources, manure, soil from pastures and grazing, and foods (silage, straw, and haylage). Species
of cultures were further identified on the basis of Novosibirsk Tuberculosis Research Institute using the time-of-flight
mass spectrometry method and on microchips. Results and Discussion. Among the pathogenic fast-growing non-
tuberculous mycobacteria in Novosibirsk Oblast, M. abscessus, M. fortuitum, M. chelonae, and less often M. magerity
and M. mucogenicum were found most frequently. Among non-pathogenic slow-growing species, M. septicum, M.
perigrinum, M. duvalii, M. senegalense, and M. monacense were found. M. gordonae was more common, in addition to
Novosibirsk, in the Kochenevsky, Ordynsky, Iskitim, and Toguchinsky districts. M.chelonae/M.abscessus complex was
found in Novosibirsk and the Vengerovsky district, M. perigrinum in the Suzunsky district, while M. nonchromogenicum
and M. fortuitum only in Novosibirsk. Among the samples obtained from animals, representatives of MAComplex were
most often found: M. avium and M. intracellulare. M.avium was more common than M. intracellulare and was found in
Vengerovsky, Karasuksky, Krasnozersky, Kochkovsky, Chulymsky, and Orda districts and in Novosibirsk. Conclusions.
3 possible foci were found in which cases of infection with mycobacteria of both humans and animals were detected.
Therefore, humans and animals are able to create reservoirs of infection that increase the cross-infection likelihood.
INQUIRY INTO THE CAUSES OF THE POSTRESECTION RECURRENCES OF PULMONARY TUBERCULOSIS IN SIBERIA AND THE FAR EAST
Authors:   Novosibirsk Tuberculosis Research Institute, MOROZOV PAVEL S. , GRISCHENKO NIKOLAY G. ,   Novosibirsk Tuberculosis Research Institute, SKVORTSOV DMITRY A. ,   Novosibirsk Tuberculosis Research Institute
Published: December 2024

Introduction. Relapsing pulmonary tuberculosis after medication and after surgical treatment is one of the
most pressing problems in phthisiology. The frequency of respiratory tuberculosis relapses is one of the indicators
characterizing the intensity of the epidemiological situation regarding tuberculosis. Therefore, the problem of relapses is
most relevant in territories that are epidemically unfavorable for tuberculosis, such as the Siberian and the Far Eastern
Federal Districts of Russia. Aim is to define the clinical determinants of pulmonary tuberculosis relapses after radical
surgery in the Siberian and the Far Eastern Federal Districts of Russia. Materials and Methods. In total, clinical cases
of 122 patients were analyzed, who had been re-operated at Novosibirsk Tuberculosis Research Institute in the period
of 2018-2022. Results and Discussion. In the studied cohort of patients, 58% of patients were found clinically cured
after surgical treatment of tuberculosis, and a relapse developed in 42% of cases, respectively. The proportion of re-
lapses that developed within 5 years after surgery in the analyzed cohort of patients was 65% of cases, while thosedeveloped within 5 to 10 years amounted to half as much. The predominant type of surgical intervention (80% of cases)
performed initially was an atypical resection. An unreasonably selected area of the initial surgical intervention led to
the development of relapse. This study has found that the proportion of concomitant immunodeficiency conditions (HIV
infections) is represented in 4% of cases. Positive clinical success was achieved mainly due to repeated resections
with minimal postoperative complications (3% of cases). Conclusions. The main clinical determinants of tuberculosis
relapse development in previously operated patients were the fibrous-cavernous form of tuberculosis, chronic obstruc-
tive pulmonary disease as a concomitant disease, the unreasonable strategies of the initial surgical interventions, such
as insufficient resection area, complicated postoperative course, inadequate anti-tuberculosis therapy, and withdrawal
of patients from treatment.
USING CALCULATIONS IN THE RECONSTRUCTIVE SURGERY OF STATIC FOREFOOT DEFORMITY (case report)
Authors:   Irkutsk Science Centre of Surgery and Traumatology, LEONOVA SVETLANA N. , USOLTSEV IVAN V. ,   Irkutsk Science Centre of Surgery and Traumatology, KOSAREVA MARIYA A. ,   Irkutsk Science Centre of Surgery and Traumatology, VASILEV VAYCHESLAV Y. ,   Irkutsk Science Centre of Surgery and Traumatology
Published: December 2024

Introduction. Studying the matters of surgically treating various forefoot static deformities and their poor
outcomes revealed the shortcomings of correction methods using metatarsal osteotomies, one of which is the lack of
preoperative calculations of the necessary reconstruction. The aim is to demonstrate how to use calculations necessary
for the forefoot reconstruction, exemplified by treating a female patient with a combination of the first- and second-toe
deformities. Materials and Methods. A clinical case is presented demonstrating the successful application of a new
surgical technique to correct the second hammer toe combined with hallux valgus, including the exact calculations of
the required values of shortening the metatarsal bone and of laterally displacing its head towards the toe deviation.
Results and Discussion. In a 63-year-old female patient, based on clinical and X-ray examinations, a mobile hammer
toe deformity was determined, accompanied by a lateral toe deviation in the metatarsophalangeal joint and metatarsalgia
under the head of the second metatarsal bone, and a deformity of the first toe, i.e., hallux valgus. Surgery was
recommended and performed. To correct the first toe deformation, the proprietary technology was successfully used.
Correction of the second toe deformation included preoperative calculations of the values required for shortening the
second metatarsal bone and displacing its head, marking two parallel lines at a distance of the shortening calculated,
and performing osteotomies of the second metatarsal at different angles with the removal of a free bone fragment,
comparison of distal and proximal fragments, lateral displacement of the metatarsal head, and screw fixation. Using
accurate preliminary calculations that allow reducing the metatarsal bone length by the required value and laterally shifting
its head towards the toe deflection in the metatarsophalangeal joint ensures the correction of the second hammer toe
and the release of the toe flexion position in the proximal interphalangeal joint, the toe extensor position and external
deviation in the metatarsophalangeal joint, and the amelioration of metatarsalgia. Conclusions. Using a new surgical
technique for the treatment of the second hammer toe, including calculations and the performance of two osteotomies
along the marked lines, allows achieving a good result and a normal ratio of metatarsal lengths, optimally redistributing
the loads on the metatarsal heads, eliminating forefoot pain and metatarsalgia manifestations, and preventing from the
development of transitional metatarsalgia and deformation recurrence.
MOBILE CLAW TOE SYNDROME (CHECKREIN DEFORMITY): a clinical case
Authors:   Irkutsk Science Centre of Surgery and Traumatology, USOLTSEV IVAN V. , LEONOVA SVETLANA N. ,   Irkutsk Science Centre of Surgery and Traumatology, GUBAR ILIYA E. ,   Irkutsk Science Centre of Surgery and Traumatology, VASILEV VAYCHESLAV Y. ,   Irkutsk Science Centre of Surgery and Traumatology
Published: December 2024

Introduction. The syndrome of mobile claw toes or, as it is commonly called in the English-language
scientific literature, checkrein deformity is a rare dynamic deformity of toes that develops secondary to any traumatic
factor at the level of the ankle joint and foot. A special aspect of the clinical example presented is that the pathology
developed without any direct impact on the above-mentioned anatomical areas. We have not found any references to or descriptions of such a clinical observation in the literature available. The aim of the publication was to demonstrate
the clinical observation of a patient with the spontaneously developed syndrome of mobile claw toes. Materials and
Methods. The article presents the outcomes of the surgical treatment of this pathology in a 52-year-old female patient
and evaluates the resulting functional changes using pedobarometric and stabilometric tests. Results and Discussion.
A 52-year-old female patient, four months after the planned surgical intervention (augmentation mammoplasty), drew
attention to the restriction of movements in the I and II metatarsophalangeal joints in a certain left foot position, which
progressed and made it difficult to walk and stand on tiptoes. No preceding injury facts have been established.
Conservative treatment did not produce the desired effect. Surgical intervention was performed, which consisted in the
release and Z-shaped elongation of the tendons of the long flexor of the first finger and the long flexor of the toes. After
the surgery, the operated foot was immobilized for 6 weeks with a posterior plaster splint at an angle of 90 degrees.
During the treatment, there were no abnormalities in the patient’s condition or in clinical and laboratory parameters.
The stitches were removed on the fourteenth day. Six weeks after the operation, immobilization was discontinued, and
walking was allowed with a gradual loading increase. The surgical intervention resulted in the relief of manifestations
of the claw toes syndrome and the restoration of foot support, which allowed the patient to return to her usual lifestyle
without any restrictions, and the objective criterion of effectiveness was the improvement of basic pedobarometric and
stabilometric indicators. Conclusions. The patient treatment outcome obtained regarding the syndrome of mobile claw
toes allows us to conclude that surgical treatment is acceptable and encourages further search for the causes of this
syndrome and possible options of preventing it.
СХЕМА МАРШРУТИЗАЦИИ ПАЦИЕНТОВ СО ЗЛОКАЧЕСТВЕННЫМИ НОВООБРАЗОВАНИЯМИ В ЧАСТНОЙ МЕДИЦИНСКОЙ ОРГАНИЗАЦИИ
Authors:   Polyclinic on Zeleny Prospekt of JSC Medsi Group of Companies, Moscow, MINAEVA ANNA K. , LISAEV DMITRY A. ,   JSC Medsi Group of Companies, KONOVALOV OLEG E. ,   Medical Institute, Peoples’ Friendship University of Russia (RUDN University), SHULAEV ALEKSEY V. ,   Kazan State Medical University, PAK VITALY I. ,   N.A. Semashko National Research Institute of Public Health
Published: December 2024

Introduction. Key factors affecting the quality and timeliness of detecting malignant diseases, as well as the
prognosis of the disease, are the correctly performed early diagnostics and correct approach to patient routing. Aim. To
analyze the algorithm for routing patients with malignant neoplasms, exemplified by a large private medical organization.
Materials and Methods. A sociological survey of 412 oncologists, surgeons, proctologists and obstetricians/gynecologists
employed in the clinics of JSC Medsi Group of Companies in Moscow and the Moscow Region was conducted using a
specially developed questionnaire. Sociological, analytical, and mathematical-statistical research methods were used for
the study. Results and Discussion. According to the survey outcomes, 72.7% of the doctors surveyed were informed
about the further routing of patients with newly diagnosed malignant neoplasms, who left the contour of JSC Medsi
Group of Companies. At the same time, a similar ratio was noted regardless of the special fields of the respondents.
The frequency of positive responses in general also did not depend on the respondents’ work experience. At the same
time, only 38.3% of doctors had feedback with patients with malignant neoplasms who left the contour of JSC Medsi
Group of Companies. It was found that, in the respondents’ opinion, the chief specialist for the Oncology Project, senior
oncologist of the medical group, or heads of departments could effectively control the route of a patient with a malignant
neoplasm when they leave the contour of this medical organization. JSC Medsi Group of Companies has developed and
implemented an effective plan (algorithm) for routing patients with suspected malignant neoplasms. When the malignant
neoplasm diagnosis is morphologically confirmed in a patient, this information is automatically displayed on the oncology
desktop and sent to the work e-mail of the doctor who has performed the biopsy, as well as of the head of the relevant
department. When a patient moves to each of the subsequent stages of treatment or refuses to continue treatment,
it is recorded on the oncology desktop of the Medialog MIS, which minimizes the likelihood of losing control over the
route of the patient with a malignant neoplasm. Conclusions. Implementing the task of monitoring the correctness of
routing a patient with a malignant neoplasm outside the scope of JSC GC Medsi will allow each patient with suspected
oncological pathology and with an established diagnosis to timely receive medical care.
MORPHOLOGICAL PICTURE OF ACUTE KIDNEY INJURY IN YOUNG CHILDREN AFTER CARDIAC SURGERY
Authors:   Republican Specialized Scientific and Practical Center of Surgery named after Academician V. Vakhidov, Tashkent, KHAYDAROV ALISHER E. , MARDONOV JAMSHD N. ,   Republican Specialized Scientific and Practical Center for Surgery named after Academician V. Vakhidov, Tashkent, SOBIROV DONIYOR M. ,   Republican Specialized Scientific and Practical Center for Surgery named after Academician V. Vakhidov, Tashkent, KHALIKULOV KHUSAN G. ,   Republican Specialized Scientific and Practical Center for Surgery named after Academician V. Vakhidov, Tashkent, IRMATOV SARVAR KH. ,   Republican Specialized Scientific and Practical Center for Surgery named after Academician V. Vakhidov, Tashkent
Published: December 2024

Introduction. The most common complication in young children after cardiac surgery is perioperative acute
kidney injury. This condition is associated with a high mortality risk and significant morphological changes in the kidneys,
which require complex and timely treatment. Aim: To improve the outcomes of combined postoperative treatment in
young children with acute kidney injury by assessing the morpho-functional structures of the kidneys, as well as the
effectiveness of early peritoneal dialysis. Materials and Methods: Clinical and anatomical analysis was performed on
the material of 23 young children who died after cardiac surgery that had included correction of congenital heart defects.
Morphological studies included investigation of their medical histories, post-mortem examinations, and histological
examinations of renal tissues. Results and Discussion. Hemodynamic disturbances were recorded on the 1st and
2nd days after surgery, including a decrease in hourly diuresis and an increase in serum creatinine levels. The main
morphological changes included necrosis of convoluted tubule nephrocytes in 48.6% of cases and dystrophic changes
in 51.3% of cases, which was accompanied by multiple organ failure. Conclusions. After the use of cardiotropic and
nephroprotective therapy, including early peritoneal dialysis, some children showed restoration of nephrons with the
formation of cellular cylinders and fixation of osmolar dialysate in the loop of Henle.
STAGED LIVER RESECTION USING ALPPS TECHNOLOGY: AN INNOVATIVE SURGICAL TECHNIQUE FOR THE TREATMENT OF MULTIPLE COLORECTAL LIVER METASTASES
Authors:   Kazan (Volga Region) Federal University, ANISIMOV ANDREY YU. , МAVLONOV FAYZALY B. ,   National Scientific Center for Transplantation of Human Organs and Tissues, Tajikistan
Published: December 2024

Introduction. Postoperative acute liver failure is a life-threatening companion of extensive liver resection
in patients with colorectal liver metastases. A surgical technique called Associating Liver Partition and Portal Vein
Ligation for Staged Hepatectomy (ALPPS) has been proposed to induce hyperplasia of the planned liver remnant. Aim.
The aim of the study is to analyze our own clinical experience of staged liver resection using the ALPPS technique in
the complex surgical treatment of multiple colorectal liver metastases to the liver and compare it with other authors’
results. Materials and Methods. In this clinical observation, two-stage liver resection using the ALPPS technique was
successfully used in the complex treatment of a male patient with multiple liver metastases of low-differentiated sigmoid
colon adenocarcinoma, stage IIIA (T2N1M0). Upon prior chemotherapy, the planned liver remnant volume was less
than 25%. Results and Discussion. Duration of the first stage of surgery was 210 minutes, and intraoperative blood
loss was 450 ml. By the eighth day of the postoperative period, the volume of the planned liver remnant increased by
9%, reaching 38%. The second stage of intervention was performed nine days after the first one. Its duration was 75
minutes, and blood loss was 150 ml. On the 16th day after the second stage of the surgery, the patient was discharged
from the hospital in satisfactory condition. A control CT scan performed three months after discharge revealed a 54%
increase in the liver remnant compared to its initial size and no new metastatic foci. The patient subsequently received
adjuvant polychemotherapy. Unfortunately, 31 months after performing the ALPPS surgery, the patient died. The death
was caused by cancer recurrence. Conclusions. The presented clinical observation demonstrates the successful and
complete completion of extensive bilobar liver resection with achievement of R0-resection in a patient with multiple
colorectal liver metastases. Despite the favorable surgical outcome, cancer recurrence was fatal.
Boletín de Noticias "Entre Patologos" de Alconpat Internacional (V6N2, 2024)
Authors:   Alconpat Internacional, Soria Castro Montserrat , Zozaya Ortíz Alexia Xiomara ,   Alconpat Internacional, Castro Borges Pedro ,   Alconpat Internacional
Published: December 2024

Esta edición del boletín de ALCONPAT Internacional recopila los principales logros y actividades de la asociación y sus delegaciones nacionales en los últimos meses. Incluye avances en educación, investigación y vinculación, destacando el trabajo de las Direcciones de Recomendaciones Técnicas y Educación, así como iniciativas como el nombramiento del nuevo Director de Jóvenes y el lanzamiento del nuevo número de la Revista ALCONPAT. El boletín también resalta eventos significativos como el VI CONPAT-Ve 2024 en Venezuela, el Seminario Internacional de Durabilidad del Concreto en Colombia, la refundación de la delegación colombiana, y las actividades PRE-CONPAT en Brasil. Asimismo, celebra los 20 años de congresos nacionales de Alconpat México, reafirmando el compromiso con la calidad, durabilidad y sostenibilidad en el sector de la construcción. Cerramos con un mensaje navideño, invitando a la reflexión y renovación de esfuerzos para continuar fortaleciendo nuestra comunidad técnica y humana en el próximo año. Este boletín es un testimonio de los retos superados y las metas alcanzadas, alentando a todos los miembros a seguir participando activamente en 2025.
A teoria do constitucionalismo democrático para a legitimação do fluxo dialógico no Brasil
Authors: Freitas Daniel Castanha de , Uessler Danielle
Published: December 2024

The theory of democratic constitutionalism idealized by American doctrine claims that the powers that form the State should promote, among themselves, movements and reciprocal interactions capable of fostering a healthy dialogical flow for the development of democracy and constitutionalism, improving constitutional jurisdiction. Conformed to a democratic rule of law, Brazil has characteristics that fully conform to this scenario of necessary search for the improvement of the branches of power. Thus, based on hypothetical-deductive methodology and bibliographic research, the work discussed, at first, the theory of democratic constitutionalism and its most correct position in relation to dichotomous and Manichaean views that advocate the “last word” of the interpretation of Constitution by the Legislative or Judiciary. Then, it was exemplified the institutional dialogue that took place between the powers based on the development of the discussion about the marriage and stable unions between same-sex couples and in bills on the subject. Finally, it was concluded that, specifically in relation to the application of the studied theory, the powers have been shown to be emancipatory and with adequate representativeness nowadays, promoting dialogues that comply with the rules of the democratic game.