bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Using Digital Tools (Metaverse, Blender, PPT) for Digital Storytelling Activities in General Education Classes on Learner's Happiness and Learning Motivation: Focusing on Poster and Video Creation Activities
Authors:   The Korean Society of Culture and Convergence, Kim Suyeon
Published: November 2023

The purpose of this study is to investigate the impact of digital storytelling activities using digital tools (Metaverse, Blender, PPT) in a university-required general education course, A.C.T. (Action, Communication, Teamwork), on learners' happiness and learning motivation. The study involved 90 learners who took the A.C.T. course in the first semester of 2022 at a C university in the Seoul metropolitan area. Happiness and learning motivation were analyzed using pre-post tests and paired-samples t-tests. The analysis results revealed that both happiness and learning motivation significantly improved in the post-test compared to the pre-test. Therefore, it can be concluded that digital storytelling activities using digital tools have an impact on learners' happiness and learning motivation. Based on these findings, this study aims to provide implications and foundational data for the educational utilization and effective application of digital tools in teaching.
Solutions-Based Approach to Urban Cat Management—Case Studies of a One Welfare Approach to Urban Cat Management
Authors: Crawford Caitlin , Rand Jacquie , Rohlf Vanessa , Scotney Rebekah , Bennett Pauleen
Published: November 2023

Urban free-roaming cats create concern about their impacts on wildlife and human health, leading to the use of trap–adopt–kill methods to manage these populations. This method is ineffective at decreasing the free-roaming cat population and has a negative impact on cat caregivers’ well-being. Using semi-structured interviews, this study explored the relationship that semi-owners (people who feed cats but do not perceive ownership) and owners of multiple cats have with the cats they care for, and the social and psychological impacts of an alternative assistive-centered approach to urban cat management. This approach to semi-owned and owned cats provided free sterilization and preventative healthcare. Our findings demonstrate that the caregivers had a strong emotional bond with the cats they cared for. The caregivers also experienced a positive impact on their quality of life, and indicated an improvement in the cats’ welfare after having the cats sterilized through this program. Additionally, the cat caregivers indicated that they had a negative view of agencies, such as the municipal council. It is recommended that an assistive-centered approach to urban cat management be prioritized by local councils and welfare agencies to improve caregivers’ quality of life and psychological well-being, whilst also improving cat welfare. The implementation of this assistive-centered management approach could improve the relationship between communities and the agencies involved, leading to the continuous reporting of free-roaming cats for sterilization. This assistive-centered approach has the potential to reduce the free-roaming cat population, their effects on wildlife, nuisance complaints, and council impoundments, and is aligned with the One Welfare philosophy.
In Situ Investigation of the Dynamic Response and Settlement in the Expressway Culvert–Subgrade Transition Section Using a Vibration Exciter
Authors: Lu Zhiqiang , Xu Linrong , Chen Yunhao , Li Yongwei , Su Na , Yan Zixuan , Ding Kui
Published: November 2023

During the operational phase of the expressway, a significant challenge arises concerning substantial differential settlement in the transition zone connecting the culvert and the general subgrade, affecting its smoothness. In order to address the issue of abrupt stiffness variations within the transition section and to mitigate the occurrence of differential settlement, a gradient pile–reinforced-concrete slab composite foundation was implemented for the first time within an expressway culvert–subgrade transition section. At the same time, an in situ vibration test was conducted through the SBZ30 vibration exciter to comprehensively understand the vertical dynamic responses in the culvert–subgrade transition section under various axle loads and speed conditions. Furthermore, continuous monitoring was conducted to track the long-term settlement of the roadbed. The findings indicate that the utilization of gradient pile–reinforced-concrete slab composite foundations can significantly mitigate the amplitude of the dynamic response parameters. Moreover, dynamic parameters and attenuation coefficients exhibit a gradual reduction as the depth increases. Dynamic stresses, acceleration, and displacements on the roadbed surface exhibited positive correlations with both the axle weight and vehicle speed. However, at deeper depths, the load weight exerted a more pronounced influence. As the speed rose, acceleration decayed faster, affecting a shallower depth. Conversely, the increased load slowed the acceleration decay. The cumulative deformation of the roadbed and the number of excitations followed exponential function characteristics. Settlement values progressively increased while the settlement rate gradually diminished, eventually reaching a stable state, ultimately stabilizing within 4.7 mm. These research outcomes offer valuable guidance and serve as a reference for the implementation of gradient pile–reinforced-concrete slab composite foundations within the culvert–subgrade transition section.
GP-Net: Image Manipulation Detection and Localization via Long-Range Modeling and Transformers
Authors: Peng Jin , Liu Chengming , Pang Haibo , Gao Xiaomeng , Cheng Guozhen , Hao Bing
Published: November 2023

With the rise of image manipulation techniques, an increasing number of individuals find it easy to manipulate image content. Undoubtedly, this presents a significant challenge to the integrity of multimedia data, thereby fueling the advancement of image forgery detection research. A majority of current methods employ convolutional neural networks (CNNs) for image manipulation localization, yielding promising outcomes. Nevertheless, CNN-based approaches possess limitations in establishing explicit long-range relationships. Consequently, addressing the image manipulation localization task necessitates a solution that adeptly builds global context while preserving a robust grasp of low-level details. In this paper, we propose GPNet to address this challenge. GPNet combines Transformer and CNN in parallel which can build global dependency and capture low-level details efficiently. Additionally, we devise an effective fusion module referred to as TcFusion, which proficiently amalgamates feature maps generated by both branches. Thorough extensive experiments conducted on diverse datasets showcase that our network outperforms prevailing state-of-the-art manipulation detection and localization approaches.
Comparing the Effects of Wildfire and Hazard Reduction Burning Area on Air Quality in Sydney
Authors: Storey Michael A. , Price Owen F.
Published: November 2023

Landscape fires emit smoke that contains particulate matter (PM) that can be harmful to human health. Prescribed fires or hazard reduction burns (HRBs) and wildfires can substantially reduce air quality in populated areas. While HRBs reduce the size and PM output of future wildfires, they also produce PM. There is a critical question of whether conducting HRBs adds to or reduces the total PM (prescribed + wildfire PM) exposure of populations, which has important community health implications. We modelled mean 24 h PM2.5 in Sydney from fire type, 24 h active regional fire area and weather predictors. We compared HRB and wildfire area effects via an interaction between fire area and fire type, and we found that a non-linear effect of fire area was most appropriate. We conducted a trade-off analysis by using the model to predict increased HRB area scenarios and calculated the number of HRB and wildfire days with ‘Fair’ or worse air quality under each scenario. Regional HRBs and wildfire areas had similar effects on PM2.5 in Sydney. Increasing regional HRB area produced substantial increases in HRB exceedance days (>12.5 µgm−3) in Sydney but only a small reduction in wildfire exceedance days. Our results indicate that small fires in the region have a higher per-hectare impact on PM levels in Sydney, and consequently, increasing regional HRB area would result in more poor air quality days overall (HRB + wildfire days) in Sydney.
Correlation between Neutrophil-to-Lymphocyte Ratio and Cerebral Edema in Children with Severe Diabetic Ketoacidosis
Authors: Scutca Alexandra-Cristina , Nicoară Delia-Maria , Mang Niculina , Jugănaru Iulius , Brad Giorgiana-Flavia , Mărginean Otilia
Published: November 2023

Diabetic ketoacidosis (DKA), a common onset modality of type 1 diabetes mellitus (T1DM), can lead, in rare instances, to the development of cerebral edema, which is the leading cause of mortality in T1DM. Aside from the identification of several demographic and clinical risk factors for cerebral edema, attention has also been drawn to the possible link between systemic inflammation and neuroinflammation. This single-center retrospective study of 98 children with severe DKA aimed to investigate the possible relationship between neutrophil-to-lymphocyte ratio NLR) levels and the presence of cerebral edema. Patients were classified into three groups: alert (n = 28), subclinical cerebral edema (n = 59), and overt cerebral edema (n = 11). Lower blood pH and elevated NLR and blood urea were correlated with the presence of cerebral edema (p < 0.001). After a multivariable risk adjustment for possible confounding factors, such as age, pH, corrected sodium, and BUN, the NLR remained positively associated with cerebral edema (p = 0.045). As such, NLR may be an additional instrument to help practitioners target patients with a higher risk of severe cerebral edema. These patients would benefit from more rigorous neurologic surveillance, enabling the prompt identification of early signs of cerebral edema.
Alexithymia, Burnout, and Hopelessness in a Large Sample of Healthcare Workers during the Third Wave of COVID-19 in Italy
Authors: De Berardis Domenico , Ceci Anna , Zenobi Emanuela , Rapacchietta Dosolina , Pisanello Manuela , Bozzi Filippo , Ginaldi Lia , Marasco Viviana , Di Giosia Maurizio , Brucchi Maurizio , Graffigna Guendalina , Santambrogio Jacopo , Ventriglio Antonio , Mazza Marianna , Muttillo Giovanni
Published: November 2023

In the present study, we aimed to assess the frequency of and the relationships between alexithymia, burnout, and hopelessness in a large sample of healthcare workers (HCWs) during the third wave of COVID-19 in Italy. Alexithymia was evaluated by the Italian version of the 20-item Toronto Alexithymia Scale (TAS-20) and its subscales Difficulty in Identifying Feelings (DIF), Difficulty in Describing Feelings (DDF), and Externally Oriented Thinking (EOT), burnout was measured with the scales emotional exhaustion (EE), depersonalisation (DP), and personal accomplishment (PA) of the Maslach Burnout Test (MBI), hopelessness was measured using the Beck Hopelessness Scale (BHS), and irritability (IRR), depression (DEP), and anxiety (ANX) were evaluated with the Italian version of the Irritability‚ Depression‚ Anxiety Scale (IDA). This cross-sectional study recruited a sample of 1445 HCWs from a large urban healthcare facility in Italy from 1 May to 31 June 2021. The comparison between individuals that were positive (n = 214, 14.8%) or not for alexithymia (n = 1231, 85.2%), controlling for age, gender, and working seniority, revealed that positive subjects showed higher scores on BHS, EE, DP IRR, DEP, ANX, DIF, DDF, and EOT and lower on PA than the not positive ones (p < 0.001). In the linear regression model, higher working seniority as well as higher EE, IRR, DEP, ANX, and DDF scores and lower PA were associated with higher hopelessness. In conclusion, increased hopelessness was associated with higher burnout and alexithymia. Comprehensive strategies should be implemented to support HCWs’ mental health and mitigate the negative consequences of alexithymia, burnout, and hopelessness.
Radical Hysterectomy or Total Mesometrial Resection—Two Anatomical Concepts for Surgical Treatment of Cancer of the Uterine Cervix
Authors: Kostov Stoyan , Sorokin Pavel , Rezende Bruno , Yalçın Hakan , Selçuk Ilker
Published: November 2023

A radical hysterectomy is the standard method of surgical treatment for patients with early-stage cancer of the uterine cervix. It was first introduced more than 100 years ago. Since then, various and many different radical procedures, which diverge in terms of radicality, have been described. Inconsistencies are clearly seen in practical anatomy, which were defined as surgically created artifacts. Moreover, the disparity of the procedure is most notable regarding the terminology of pelvic connective tissues and spaces. Despite these controversies, the procedure is widely performed and implemented in the majority of guidelines for the surgical treatment of cancer of the uterine cervix. However, a different and unique concept of surgical treatment of cervical cancer has been reported. It is based on ontogenetic anatomy and maps any tissue in the mature organism according to its embryologic development. The clinical implementation of this theory in the context of early cervical cancer is total mesometrial resection. The present article aims to describe and compare the anatomical and surgical basics of a radical hysterectomy (type C1/C2) and total mesometrial resection. Discrepancies regarding the terminology, resection lines, and surgical planes of both procedures are highlighted in detail. The surgical anatomy of the pelvic autonomic nerves and its surgical dissection is also delineated. This is the first article that compares the discrepancy of classic anatomy and ontogenic anatomy regarding surgical treatment of cancer of the uterine cervix. Clinical data, oncological outcome, and neoadjuvant and adjuvant treatment regarding both procedures are not the topic of the present article.
Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features
Authors: Guerra Adalgisa , Alves Filipe Caseiro , Maes Kris , Maio Rui , Villeirs Geert , Mouriño Helena
Published: November 2023

Objectives: This study aimed to assess the impact of the covariates derived from a predictive model for detecting extracapsular extension on pathology (pECE+) on biochemical recurrence-free survival (BCRFS) within 4 years after robotic-assisted radical prostatectomy (RARP). Methods: Retrospective data analysis was conducted from a single center between 2015 and 2022. Variables under consideration included prostate-specific antigen (PSA) levels, patient age, prostate volume, MRI semantic features, and Grade Group (GG). We also assessed the influence of pECE+ and positive surgical margins on BCRFS. To attain these goals, we used the Kaplan–Meier survival function and the multivariable Cox regression model. Additionally, we analyzed the MRI features on BCR (biochemical recurrence) in low/intermediate risk patients. Results: A total of 177 participants with a follow-up exceeding 6 months post-RARP were included. The 1-year, 2-year, and 4-year risks of BCR after radical prostatectomy were 5%, 13%, and 21%, respectively. The non-parametric approach for the survival analysis showed that adverse MRI features such as macroscopic ECE on MRI (mECE+), capsular disruption, high tumor capsular contact length (TCCL), GG ≥ 4, positive surgical margins (PSM), and pECE+ on pathology were risk factors for BCR. In low/intermediate-risk patients (pECE− and GG < 4), the presence of adverse MRI features has been shown to increase the risk of BCR. Conclusions: The study highlights the importance of incorporating predictive MRI features for detecting extracapsular extension pre-surgery in influencing early outcomes and clinical decision making; mECE+, TCCL, capsular disruption, and GG ≥ 4 based on pre-surgical biopsy were independent prognostic factors for early BCR. The presence of adverse features on MRI can assist in identifying low/intermediate-risk patients who will benefit from closer monitoring.
Surgical Phase Duration in Robot-Assisted Partial Nephrectomy: A Surgical Data Science Exploration for Clinical Relevance
Authors: De Backer Pieter , Peraire Lores Maria , Demuynck Meret , Piramide Federico , Simoens Jente , Oosterlinck Tim , Bogaert Wouter , Shan Chi Victor , Van Regemorter Karel , Wastyn Aube , Checcucci Enrico , Debbaut Charlotte , Van Praet Charles , Farinha Rui , De Groote Ruben , Gallagher Anthony , Decaestecker Karel , Mottrie Alexandre
Published: November 2023

(1) Background: Surgical phases form the basic building blocks for surgical skill assessment, feedback, and teaching. The phase duration itself and its correlation with clinical parameters at diagnosis have not yet been investigated. Novel commercial platforms provide phase indications but have not been assessed for accuracy yet. (2) Methods: We assessed 100 robot-assisted partial nephrectomy videos for phase durations based on previously defined proficiency metrics. We developed an annotation framework and subsequently compared our annotations to an existing commercial solution (Touch Surgery, Medtronic™). We subsequently explored clinical correlations between phase durations and parameters derived from diagnosis and treatment. (3) Results: An objective and uniform phase assessment requires precise definitions derived from an iterative revision process. A comparison to a commercial solution shows large differences in definitions across phases. BMI and the duration of renal tumor identification are positively correlated, as are tumor complexity and both tumor excision and renorrhaphy duration. (4) Conclusions: The surgical phase duration can be correlated with certain clinical outcomes. Further research should investigate whether the retrieved correlations are also clinically meaningful. This requires an increase in dataset sizes and facilitation through intelligent computer vision algorithms. Commercial platforms can facilitate this dataset expansion and help unlock the full potential, provided that the phase annotation details are disclosed.
Diagnostic Performance of an Artificial Intelligence Model Based on Contrast-Enhanced Ultrasound in Patients with Liver Lesions: A Comparative Study with Clinicians
Authors: Urhuț Marinela-Cristiana , Săndulescu Larisa Daniela , Streba Costin Teodor , Mămuleanu Mădălin , Ciocâlteu Adriana , Cazacu Sergiu Marian , Dănoiu Suzana
Published: November 2023

Contrast-enhanced ultrasound (CEUS) is widely used in the characterization of liver tumors; however, the evaluation of perfusion patterns using CEUS has a subjective character. This study aims to evaluate the accuracy of an automated method based on CEUS for classifying liver lesions and to compare its performance with that of two experienced clinicians. The system used for automatic classification is based on artificial intelligence (AI) algorithms. For an interpretation close to the clinical setting, both clinicians knew which patients were at high risk for hepatocellular carcinoma (HCC), but only one was aware of all the clinical data. In total, 49 patients with 59 liver tumors were included. For the benign and malignant classification, the AI model outperformed both clinicians in terms of specificity (100% vs. 93.33%); still, the sensitivity was lower (74% vs. 93.18% vs. 90.91%). In the second stage of multiclass diagnosis, the automatic model achieved a diagnostic accuracy of 69.93% for HCC and 89.15% for liver metastases. Readers demonstrated greater diagnostic accuracy for HCC (83.05% and 79.66%) and liver metastases (94.92% and 96.61%) compared to the AI system; however, both were experienced sonographers. The AI model could potentially assist and guide less-experienced clinicians to discriminate malignant from benign liver tumors with high accuracy and specificity.
Image Encryption Using a New Hybrid Chaotic Map and Spiral Transformation
Authors: Jiang Mingfang , Yang Hengfu
Published: November 2023

Image encryption based on chaotic maps is an important method for ensuring the secure communication of digital multimedia on the Internet. To improve the encryption performance and security of image encryption systems, a new image encryption algorithm is proposed that employs a compound chaotic map and random cyclic shift. First, a new hybrid chaotic system is designed by coupling logistic, ICMIC, Tent, and Chebyshev (HLITC) maps. Comparison tests with previous chaotic maps in terms of chaotic trajectory, Lyapunov exponent, and approximate entropy illustrate that the new hybrid chaotic map has better chaotic performance. Then, the proposed HLITC chaotic system and spiral transformation are used to develop a new chaotic image encryption scheme using the double permutation strategy. The new HLITC chaotic system is used to generate key sequences used in the image scrambling and diffusion stages. The spiral transformation controlled by the chaotic sequence is used to scramble the pixels of the plaintext image, while the XOR operation based on a chaotic map is used for pixel diffusion. Extensive experiments on statistical analysis, key sensitivity, and key space analysis were conducted. Experimental results show that the proposed encryption scheme has good robustness against brute-force attacks, statistical attacks, and differential attacks and is more effective than many existing chaotic image encryption algorithms.
Coupled Effects of Lorentz Force, Radiation, and Dissipation on the Dynamics of a Hybrid Nanofluid over an Exponential Stretching Sheet
Authors: Zahid Muhammad , Basit Abdul , Ullah Tariq , Ali Bagh , Liśkiewicz Grzegorz
Published: November 2023

The flow and heat transfer induced by an exponentially shrinking sheet with hybrid nanoparticles are investigated comprehensively in this paper. Nanoparticles are considered due to their unusual characteristics such as extraordinary thermal conductivity, which is significant in advanced nanotechnology, heat exchangers, material sciences, and electronics. The main objective of this research is to enhance heat transportation. The flow model is first transformed and simplified to a system of ordinary differential equations utilizing non-dimensional quantities and similarity functions. Then, the desired system is solved with the help of the Runge–Kutta numerical method and the shooting technique in MATLAB script. The results show that a stronger porosity parameter raises the temperature while diminishing the velocity. Additionally, they emphasize that augmentations in the magnetic parameter, Eckert number, radiation parameter, and the volume fractions of titanium dioxide and silver nanoparticles are all proportional to the temperature profile.
Promoting Universal Equitable Accessibility: An Overview on the Impact of Assistive Technology in the UN, UNICEF, and WHO Web Portals
Authors: Simeoni Rossella , Pirrera Antonia , Meli Paola , Giansanti Daniele
Published: November 2023

The number of people with disabilities and frailties who need support and assistance is increasing. Assistive technologies (ATs) are increasingly playing a central role in supporting people with disabilities and frailties. The study investigated the impact of the ATs on the websites of the UN, UNICEF, and WHO in terms of proposed activities and actions. The methodology proposed was based on two points of view: (1) A formal process to directly select elements in the institutional webs of the UN, UNICEF, and WHO. (2) A formal process for a complementary literature narrative review based on an umbrella review of Pubmed and Scopus. A standard checklist and a qualification process were applied. The outcome reported 35 documents from the direct search on the web and 19 systematic reviews for the complimentary literature overview. The direct search returned documents related to initiatives focused on the following: The tailoring of the ATs to a person based on international guidelines and specific monitoring initiatives of the AT introduction/access based on surveys both at the population and system/government level with the publication of the data/metadata in an observatory. Dissemination initiatives of both the culture of ATs (e.g., catalog, guidelines, reports, congresses) and of recommendations. The literature overview contributed more specifically to the use and effectiveness of categories of ATs. Both direct research and the literature overview have shown a consistent growth in interest in ATs. The initiatives of the UN, UNICEF, and WHO have been consistent with the institutional role and aimed at improving the diffusion of ATs through capillary monitoring, which is not free from obstacles, and a diffusion of the culture and rational use of ATs. The narrative review shows also the important role of research in monitoring the development, use, and effectiveness of devices, strategies, and support of international institutional initiatives. Important initiatives have been launched internationally on AT in terms of monitoring, dissemination, and improvement in access. However, it is necessary to consider and face the obstacles that limit these initiatives.
Telomere Checkpoint in Development and Aging
Authors: Kalmykova Alla
Published: November 2023

The maintenance of genome integrity through generations is largely determined by the stability of telomeres. Increasing evidence suggests that telomere dysfunction may trigger changes in cell fate, independently of telomere length. Telomeric multiple tandem repeats are potentially highly recombinogenic. Heterochromatin formation, transcriptional repression, the suppression of homologous recombination and chromosome end protection are all required for telomere stability. Genetic and epigenetic defects affecting telomere homeostasis may cause length-independent internal telomeric DNA damage. Growing evidence, including that based on Drosophila research, points to a telomere checkpoint mechanism that coordinates cell fate with telomere state. According to this scenario, telomeres, irrespective of their length, serve as a primary sensor of genome instability that is capable of triggering cell death or developmental arrest. Telomeric factors released from shortened or dysfunctional telomeres are thought to mediate these processes. Here, we discuss a novel signaling role for telomeric RNAs in cell fate and early development. Telomere checkpoint ensures genome stability in multicellular organisms but aggravates the aging process, promoting the accumulation of damaged and senescent cells.
Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells
Authors: Zhang Ying , Zheng Huanyu , Xu Ming , Maeda Noriko , Tsunedomi Ryouichi , Kishi Hiroko , Nagano Hiroaki , Kobayashi Sei
Published: November 2023

Metastasis is the leading cause of death in breast cancer patients due to the lack of effective therapies. Elevated levels of paxillin expression have been observed in various cancer types, with tyrosine phosphorylation shown to play a critical role in driving cancer cell migration. However, the specific impact of the distinct tyrosine phosphorylation events of paxillin in the progression of breast cancer remains to be fully elucidated. Here, we found that paxillin overexpression in breast cancer tissue is associated with a patient’s poor prognosis. Paxillin knockdown inhibited the migration and invasion of breast cancer cells. Furthermore, the phosphorylation of paxillin tyrosine residue 31 (Tyr31) was significantly increased upon the TGF-β1-induced migration and invasion of breast cancer cells. Inhibiting Fyn activity or silencing Fyn decreases paxillin Tyr31 phosphorylation. The wild-type and constitutively active Fyn directly phosphorylate paxillin Tyr31 in an in vitro system, indicating that Fyn directly phosphorylates paxillin Tyr31. Additionally, the non-phosphorylatable mutant of paxillin at Tyr31 reduces actin stress fiber formation, migration, and invasion of breast cancer cells. Taken together, our results provide direct evidence that Fyn-mediated paxillin Tyr31 phosphorylation is required for breast cancer migration and invasion, suggesting that targeting paxillin Tyr31 phosphorylation could be a potential therapeutic strategy for mitigating breast cancer metastasis.
Disruption of Intranasal GnRH Neuronal Migration Route into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo Rodent Models
Authors: Sharova Viktoria , Ignatiuk Vasilina , Izvolskaia Marina , Zakharova Liudmila
Published: November 2023

Maternal immune activation results in altered levels of cytokines in the maternal–fetal system, which has a negative impact on fetal development, including the gonadotropin-releasing hormone (GnRH) system, which is crucial for the reproduction. Suppression of GnRH–neuron migration may be associated with cytokine imbalances, and primarily with proinflammatory cytokine interleukin (IL)-6. This study aimed to determine the effects of IL-6 and monoclonal antibody to IL-6 or IL-6R or polyclonal IgG on the formation of migration route of GnRH–neurons in ex vivo and in vivo rodent models on day 11.5 of embryonic development. The increased level of IL-6 in mouse nasal explants suppressed peripherin-positive fiber outgrowth, while this led to an increase in the number of GnRH–neurons in the nose and olfactory bulbs and a decrease in their number in the fetal brain. This effect is likely to be realized via IL-6 receptors along the olfactory nerves. The suppressive effect of IL-6 was diminished by monoclonal antibodies to IL-6 or its receptors and by IgG.
Distinctive Electric Properties of Group 14 Oxides: SiO2, SiO, and SnO2
Authors: Guerreiro Antonio Nuno , Costa Ilidio B. , Vale Antonio B. , Braga Maria Helena
Published: November 2023

The oxides of group 14 have been widely used in numerous applications in glass, ceramics, optics, pharmaceuticals, and food industries and semiconductors, photovoltaics, thermoelectrics, sensors, and energy storage, namely, batteries. Herein, we simulate and experimentally determine by scanning kelvin probe (SKP) the work functions of three oxides, SiO2, SiO, and SnO2, which were found to be very similar. Electrical properties such as electronic band structure, electron localization function, and carrier mobility were also simulated for the three crystalline oxides, amorphous SiO, and surfaces. The most exciting results were obtained for SiO and seem to show Poole–Frankel emissions or trap-assisted tunneling and propagation of surface plasmon polariton (SPP) with nucleation of solitons on the surface of the Aluminum. These phenomena and proposed models may also describe other oxide-metal heterojunctions and plasmonic and metamaterials devices. The SiO2 was demonstrated to be a stable insulator interacting less with the metals composing the cell than SnO2 and much less than SiO, configuring a typical Cu/SiO2/Al cell potential well. Its surface charge carrier mobility is small, as expected for an insulator. The highest charge carrier mobility at the lowest conduction band energy is the SnO2’s and the most symmetrical the SiO’s with a similar number of electron holes at the conduction and valence bands, respectively. The SnO2 shows it may perform as an n-type semiconductor.
Chitinase 3-like-1 Expression in the Microenvironment Is Associated with Neutrophil Infiltration in Bladder Cancer
Authors: Xiao Ling-Yi , Su Yu-Li , Huang Shih-Yu , Chen Yi-Hua , Hsueh Po-Ren
Published: November 2023

Bladder cancer is a common cancer with well-established therapeutic strategies. However, recurrence occurs in 50% of patients with non-muscle-invasive bladder cancer, and 20% of patients progress to muscle-invasive bladder cancer. The 5-year survival rate for muscle-invasive bladder cancer patients is disappointingly low, ranging from 36% to 48%. A molecular marker of interest is chitinase 3-like-1 (CHI3L1), which is elevated in various cancers, including bladder cancer. In addition to its role in cancer cells, CHI3L1 also has regulatory abilities in immune cells. Neutrophil infiltration has been shown to positively correlate with overall survival, progression-free survival, and relapse-free survival in bladder cancer patients. However, the relationship between CHI3L1 and neutrophils remain poorly understood. Therefore, this study investigated the relationship between CHI3L1 level and protumor neutrophil infiltration in bladder cancer. We analyzed the GSE128959 dataset and the data of a bladder cancer cohort undergoing chemotherapy. We observed higher expression of CHI3L1 in bladder cancer patients with invasive or chemotherapy-resistance. Our results revealed a positive correlation between CHI3L1 expression and protumor neutrophil infiltration. Elevated CHI3L1 expression was associated with genes which were related to the recruitment and infiltration of neutrophils. Consequently, CHI3L1 may serve as a novel evaluation factor for the degree of neutrophil infiltration in advanced bladder cancer in those scheduled for chemotherapy.
EACH-COA: An Energy-Aware Cluster Head Selection for the Internet of Things Using the Coati Optimization Algorithm
Authors: Somula Ramasubbareddy , Cho Yongyun , Mohanta Bhabendu Kumar
Published: November 2023

In recent years, the Internet of Things (IoT) has transformed human life by improving quality of life and revolutionizing all business sectors. The sensor nodes in IoT are interconnected to ensure data transfer to the sink node over the network. Owing to limited battery power, the energy in the nodes is conserved with the help of the clustering technique in IoT. Cluster head (CH) selection is essential for extending network lifetime and throughput in clustering. In recent years, many existing optimization algorithms have been adapted to select the optimal CH to improve energy usage in network nodes. Hence, improper CH selection approaches require more extended convergence and drain sensor batteries quickly. To solve this problem, this paper proposed a coati optimization algorithm (EACH-COA) to improve network longevity and throughput by evaluating the fitness function over the residual energy (RER) and distance constraints. The proposed EACH-COA simulation was conducted in MATLAB 2019a. The potency of the EACH-COA approach was compared with those of the energy-efficient rabbit optimization algorithm (EECHS-ARO), improved sparrow optimization technique (EECHS-ISSADE), and hybrid sea lion algorithm (PDU-SLno). The proposed EACH-COA improved the network lifetime by 8–15% and throughput by 5–10%.
Comparison of Impairments, Activity Limitations, Balance, and Quality of Life between Patients with and without Meniscus Repair or Partial Meniscectomy Post-ACL Reconstruction
Authors: Asiri Faya Ali , Assiri Abdullah Hassan , Alqhtani Abdulrhman Abdullh , Alqahtani Mohammed Hassan , Motlag Dhuha Saeed , Tedla Jaya Shanker , Reddy Ravi Shankar , Alwadai Saad Ali
Published: November 2023

(1) Background: The anterior cruciate ligament (ACL) is a crucial ligament in the knee joint. This study compares the differences in knee range of motion (ROM), knee proprioception error, balance, function, and quality of life (QOL) among participants with and without meniscus repair or partial meniscectomy nine months post ACL reconstruction. (2) Methods: In this cross-sectional study, 57 male participants were selected through convenience sampling from a tertiary care hospital. Knee flexion and extension ROM were assessed using a digital goniometer; a digital inclinometer was used to assess knee proprioception error; the Y balance test was used to evaluate balance; the lower extremity functional scale (LEFS) was used to assess activity; and QOL was assessed using the ACLQOL questionnaire. (3) Results: There were no significant differences in outcomes except balance. The YB composite score had a moderate negative correlation with knee proprioception error with an R-value of −0.372 **. (4) Conclusions: Nine to 12 months post ACL reconstruction, the isolated ACL reconstruction participants had better lower-quarter single-leg balance than those who underwent ACL reconstruction and meniscal repair or partial meniscectomy. The remaining parameters, like knee ROM, knee proprioception error, LEFS score, and ACLQOL scores, were similar between these two groups.
Analysis of Typhoon-Induced Wave Overtopping Vulnerability Due to Sea Level Rise Using a Coastal–Seawall–Terrestrial Seamless Grid System
Authors: Suh Seung-Won , Lee Myeong-Hee
Published: November 2023

The vulnerability to coastal disasters resulting from storm surges and wave overtopping (WOT) during typhoon intrusions is significantly escalating due to rising sea levels. In particular, coastal seawalls constructed along the coast through engineered assessments are experiencing an increase in the frequency of WOT and associated flooding in proportion to the reduction in freeboard due to rising sea levels. This study employed a unified modeling system that combines an empirical formula for estimating WOT volumes with a numerical model simulating tides, waves, and storm surges. The analysis was conducted across the Northwest Pacific (NWP) Ocean, encompassing coastal seawalls and terrestrial regions, using an integrated seamless grid system, which utilized ADCIRC + SWAN + EurOtop, for the present day, 2050, 2070, and 2100 to investigate how vulnerability to WOT changes with sea level rise. The maximum envelope of WOT inundation results for three historical and two 100-year return period synthetic typhoons confirms that vulnerability to WOT intensifies with rising sea levels. The single-process integrated model applied in this study can serve not only for long-term coastal seawall protection design but also for the short-term early warning system for storm surges and WOT, contributing to immediate preparedness efforts.
Listeria monocytogenes ST37 Distribution in the Moscow Region and Properties of Clinical and Foodborne Isolates
Authors: Voronina Olga L. , Kunda Marina S. , Ryzhova Natalia N. , Aksenova Ekaterina I. , Kustova Margarita A. , Karpova Tatiana I. , Melkumyan Alina R. , Klimova Elena A. , Gruzdeva Olga A. , Tartakovsky Igor S.
Published: November 2023

Listerias of the phylogenetic lineage II (PLII) are common in the European environment and are hypovirulent. Despite this, they caused more than a third of the sporadic cases of listeriosis and multi-country foodborne outbreaks. L. monocytogenes ST37 is one of them. During the COVID-19 pandemic, ST37 appeared in clinical cases and ranked second in occurrence among food isolates in the Moscow region. The aim of this study was to describe the genomic features of ST37 isolates from different sources. All clinical cases of ST37 were in the cohort of male patients (age, 48–81 years) with meningitis–septicemia manifestation and COVID-19 or Influenza in the anamnesis. The core genomes of the fish isolates were closely related. The clinical and meat isolates revealed a large diversity. Prophages (2–4/genome) were the source of the unique genes. Two clinical isolates displayed pseudolysogeny, and excided prophages were A006-like. In the absence of plasmids, the assortment of virulence factors and resistance determinants in the chromosome corresponded to the hypovirulent characteristics. However, all clinical isolates caused severe disease, with deaths in four cases. Thus, these studies allow us to speculate that a previous viral infection increases human susceptibility to listeriosis.
Microstructure and Wear Resistance of Fe3Al Coating on Grey Cast Iron Prepared via Direct Energy Deposition
Authors: Rajaei Hossein , Amirabdollahian Sasan , Menapace Cinzia , Straffelini Giovanni , Gialanella Stefano
Published: November 2023

In this study, the potential of Fe3Al coating material as an environmentally friendly alternative to coatings containing critical elements for brake discs was investigated. A buffer layer of Cr–Mo steel (Ferro 55) that was about 500 µm thick was applied on a gray cast iron disc to enhance the coating quality and prevent the formation of hot cracks during solidification. The microstructural analysis of the cross-section of the coating showed that the buffer layer diffused into the Fe3Al coating, forming a combination of Fe3Al, Fe, and Fe3AlC0.5 phases. The tribological properties of the Fe3Al-coated disc were evaluated using pin-on-disc tests against two different copper-free friction materials extracted from commercial brake pads. The wear results show a coefficient of friction comparable to that of an uncoated disc (≈0.55), but with a reduction in particulate matter (PM) emissions, which decreased from 600 to 476 #/cm3. The last issue is an interesting aspect that is gaining increasing importance in view of the upcoming international standards.
Tensile and Tearing Properties of a Geocomposite Mechanically Damaged by Repeated Loading and Abrasion
Authors: Carneiro José Ricardo , Almeida Filipe , Carvalho Filipa , Lopes Maria de Lurdes
Published: November 2023

The behaviour of geosynthetics can be affected by many agents, both in the short and long term. Mechanical damage caused by repeated loading or abrasion are examples of agents that may induce undesirable changes in the properties of geosynthetics. The research conducted in this work complemented previous studies and consisted of submitting a geocomposite, isolated and successively, to two degradation tests: mechanical damage under repeated loading and abrasion. The geocomposite (a nonwoven geotextile reinforced with polyethylene terephthalate filaments) was tested on both sides (with or without filaments) and directions (machine and cross-machine). The impact of the degradation tests on the geocomposite was quantified by monitoring changes in its tensile and tearing behaviour. The results showed that, in most cases, the degradation tests caused the deterioration of the tensile and tearing behaviour of the geocomposite, affecting its reinforcement function. The decline in tensile strength correlated reasonably well with the decline in tearing strength. Changing the side and direction tested influenced, in some cases (those involving abrasion), the degradation experienced by the geocomposite. The reduction factors (referring to tensile and tearing strength) for the combined effect of the degradation agents tended to be lower when determined by using the common method (compared to those resulting directly from the successive exposure to both agents).
High-Precision Optical Excited Heaters Based on Au Nanoparticles and Water-Soluble Porphyrin
Authors: Povolotskiy Alexey V. , Smirnova Oksana S. , Soldatova Diana A. , Povolotckaia Anastasia V. , Lukyanov Daniil A.
Published: November 2023

Gold nanoparticles are widely used as local heaters under optical excitation. Hybrid molecular-plasmon nanostructures based on gold nanoparticles and water-soluble porphyrin have been developed. A colloidal solution of gold nanoparticles was obtained by laser ablation of metallic gold in water, ensuring its highest chemical purity. The hybrid nanostructures formation was performed due to the Coulomb interaction of cationic porphyrin and gold nanoparticles. The revealed functional properties of hybrid nanostructures make them promising for controllable nano-heater applications (for example, photothermal therapy). Gold nanoparticles act as heaters, whereas porphyrin serves as a fluorescent thermometer with a single optical excitation.
The Dynamic Tunability of Memristor-Based Active Filters
Authors: Marković Ivo , Potrebić Ivaniš Milka , Tošić Dejan
Published: November 2023

When the memristor was fabricated for the first time, it launched an entirely new field of research. Many of the published papers regarding memristors are primarily theoretical and are based on computer simulations. Some recent papers analyze the memristor’s programming circuits, but to the best of the authors’ knowledge, no memristor has been embedded into a commercial analog circuit. This paper is practically oriented and it is based on the experimental results obtained by measurements on the circuit prototype. We present a solution for automated programming of a commercially available memristor and its implementation in tunable active bandpass filter design. The novelty of this paper is that the active bandpass filter’s central frequency could be programmed during the filter operation, so a pause for memristor state-switching is not required. The experimental results are promising, and open up possibilities for the memristor’s application in analog systems.
Prevalence of Eating Disorders and Their Association with Social Media Addiction among Youths
Authors: Mushtaq Tehreem , Ashraf Seemab , Hameed Huma , Irfan Ali , Shahid Maria , Kanwal Rabbia , Aslam Muhammad Arslan , Shahid Hijab , Koh-E-Noor  , Shazly Gamal A. , Khan Mahtab Ahmad , Jardan Yousef A. Bin
Published: November 2023

Eating disorders and excessive attachment to social media are a matter of great concern among youths. This study assessed the prevalence of eating disorders and their association with social media addiction among youths. A descriptive cross-sectional study was conducted on 350 participants aged 14–25 years. Two pre-validated tools were used, i.e., the Eating Attitude Test and the Social Networking Addiction Scale. SPSS was used to analyze the data. Out of the 350 students, 42% had probable eating disorders, and 41.7% had social media addictions. The findings revealed that the chances of having eating disorders were significantly higher among youths who lived in separate places, smoked, and had a family history of eating disorders (p ≤ 0.05). Furthermore, the dieting domain displayed notably higher scores for youths living separately (p ≤ 0.05) and smokers (p ≤ 0.01). Moreover, the scores for bulimia and food preoccupation were significantly higher among participants who were married (p = 0.038), were smokers (p = 0.027), and had a family history of eating disorders (p = 0.001). Higher scores in the oral control domain were reported by females (p ≤ 0.05) and severely obese youths (p ≤ 0.01). Moreover, social media addiction was significantly higher among students aged 18–21 (p ≤ 0.01). Spearman’s correlation revealed that social media addiction has a weak positive relationship with eating disorders (r = 0.133, p ≤ 0.01), particularly bulimia and food preoccupation (r = 0.173, p ≤ 0.001). This reflects the need to address the harmful consequences of social media addiction that might raise the likelihood of developing eating disorders, particularly bulimia nervosa.
Targeting 7KCh-Induced Cell Death Response Mediated by p38, P2X7 and GSDME in Retinal Pigment Epithelium Cells with Sterculic Acid
Authors: Pariente Ana , Peláez Rafael , Ochoa Rodrigo , Pérez-Sala Álvaro , Villanueva-Martínez Ángela , Bobadilla Miriam , Larráyoz Ignacio M.
Published: November 2023

Age-related macular degeneration (AMD) is the main cause of blindness in developed countries. AMD is characterized by the formation of drusen, which are lipidic deposits, between retinal pigment epithelium (RPE) and the choroid. One of the main molecules accumulated in drusen is 7-Ketocholesterol (7KCh), an oxidized-cholesterol derivative. It is known that 7KCh induces inflammatory and cytotoxic responses in different cell types and the study of its mechanism of action is interesting in order to understand the development of AMD. Sterculic acid (SA) counteracts 7KCh response in RPE cells and could represent an alternative to improve currently used AMD treatments, which are not efficient enough. In the present study, we determine that 7KCh induces a complex cell death signaling characterized by the activation of necrosis and an alternative pyroptosis mediated by P2X7, p38 and GSDME, a new mechanism not yet related to the response to 7KCh until now. On the other hand, SA treatment can successfully attenuate the activation of both necrosis and pyroptosis, highlighting its therapeutic potential for the treatment of AMD.