bluuebunny/crossref_metadata_2025 huggingface dataset:
On-Bottom Stability of Umbilicals and Power Cables for Offshore Wind Applications
Authors: Ji Guomin , Ong Muk Chen
Published: September 2019

With the increase in offshore wind farms, the demands for umbilicals and power cables have increased. The on-bottom stability of umbilicals and power cables under the combined wave and current loading is the most challenging design issue, due to their light weight and the complex fluid–cable–soil interaction. In the present study, the methodology for dynamic lateral stability analysis is first discussed; and the reliable hydrodynamic load model and cable–soil interaction model based on large experimental test data are described in detail. The requirement of the submerged weight of a cable w s to obtain on-bottom stability is investigated for three types of soil (clay, sand and rock), using the finite element program PONDUS, and the results are w s , r o c k > w s , c l a y > w s , s a n d under the same load conditions. Several different aspects related to optimization design of the on-bottom stability are explored and addressed. There is a significant benefit for the on-bottom stability analysis to consider the reduction factors, due to penetration for clay and sand soil. The on-bottom stability is very sensitive to the relative initial embedment z 0 / D for clay and sand soil, due to the small diameter of the cables, and therefore, reliable prediction of initial embedment is required. In the energy-based cable–soil interaction model, the friction coefficient μ and the development of penetration affect each other and the total effect of friction force F f and passive resistance F r is complicated. The effect of the friction coefficient μ on the on-bottom stability is different from engineering judgement based on the Coulomb friction model. The undrained shear strength of clay is an important parameter for the on-bottom stability of umbilicals and cables. The higher the undrained shear strength of the clay, the larger the lateral displacement. Meanwhile, the submerged weight of sand has a minor effect on the lateral displacement of cables. The method used in the present study significantly improves the reliability of the on-bottom stability analysis of umbilicals and power cables for offshore wind application.
Design Optimization of a Permanent-Magnet Flux-Switching Generator for Direct-Drive Wind Turbines
Authors: Dmitrievskii Vladimir , Prakht Vladimir , Kazakbaev Vadim
Published: September 2019

Due to the increasing need for direct-drive wind turbines, a large number of papers are dedicated to the optimization of low-speed wind generators. A permanent-magnet flux-switching machine can be a valuable option to use in such applications. This paper describes the optimization procedure of a direct-drive flux-switching wind generator. The average losses, the required converter power, and the cost of permanents magnets were chosen as the optimization objectives. To reduce the calculation efforts during the optimization, a method to construct the substituting load profiles is proposed. Two-mode and three-mode substituting profiles were constructed on the basis of the nine-mode initial profile. The losses calculated under the two-mode, three-mode, and nine-mode profiles accurately coincided, which supported the use of the low-mode substituting profiles instead of the initial one. During the optimization, the average losses decreased by 30%, which corresponded to an increase in the average efficiency by almost 6%. The required converter power was decreased by 10%. The total active material mass, cogging torque, and torque ripple were also slightly decreased.
The Vulnerability of the Power Sector to Climate Variability and Change: Evidence from Indonesia
Authors: Handayani Kamia , Filatova Tatiana , Krozer Yoram
Published: September 2019

The power sector is a key target for reducing CO2 emissions. However, little attention has been paid to the sector’s vulnerability to climate change. This paper investigates the impacts of severe weather events and changes in climate variables on the power sector in developing countries, focusing on Indonesia as a country with growing electricity infrastructure, yet being vulnerable to natural hazards. We obtain empirical evidence concerning weather and climate impacts through interviews and focus group discussions with electric utilities along the electricity supply chain. These data are supplemented with reviews of utilities’ reports and published energy sector information. Our results indicate that severe weather events often cause disruptions in electricity supply—in the worst cases, even power outages. Weather-related power outages mainly occur due to failures in distribution networks. While severe weather events infrequently cause shutdowns of power plants, their impact magnitude is significant if it does occur. Meanwhile, transmission networks are susceptible to lightning strikes, which are the leading cause of the networks’ weather-related failures. We also present estimates of financial losses suffered by utilities due to weather-related power disruptions and highlights their adaptation responses to those disruptions.
A Mixed-Integer Convex Programming Algorithm for Security-Constrained Unit Commitment of Power System with 110-kV Network and Pumped-Storage Hydro Units
Authors: Lin Shunjiang , Fan Guansheng , Lu Yuan , Liu Mingbo , Lu Yi , Li Qifeng
Published: September 2019

The secure operation of 110-kV networks should be considered in the optimal generation dispatch of regional power grids in large central cities. However, since 110-kV lines do not satisfy the premise of R << X in the direct current power flow (DCPF) model, the DCPF, which is mostly applied in the security-constrained unit commitment (SCUC) problem of high-voltage power grids, is no longer suitable for describing the active power flow of regional power grids in large central cities. Hence, the quadratic active power flow (QAPF) model considering the resistance of lines is proposed to describe the network security constraints, and an SCUC model for power system with 110-kV network and pumped-storage hydro (PSH) units is established. The analytical expressions of the spinning reserve (SR) capacity of PSH units are given considering different operational modes, and the SR capacity of PSH units is included in the constraint of the SR capacity requirement of the system. The QAPF is a set of quadratic equality constraints, making the SCUC model a mixed-integer nonlinear non-convex programming (MINNP) model. To reduce the computational complexity of solving the model when applied in actual large-scale regional networks, the QAPF model is relaxed by its convex hull, and the SCUC model is transformed into a mixed-integer convex programming (MICP) model, which can be solved to obtain the global optimal solution efficiently and reliably by the mature commercial solver GUROBI (24.3.3, GAMS Development Corporation, Guangzhou, China). Test results on the IEEE-9 bus system, the PEGASE 89 bus system and the Shenzhen city power grid including the 110-kV network demonstrate that the relaxed QAPF model has good calculation accuracy and efficiency, and it is suitable for solving the SCUC problem in large-scale regional networks.
Modeling of a PCM TES Tank Used as an Alternative Heat Sink for a Water Chiller. Analysis of Performance and Energy Savings
Authors: Real-Fernández Antonio , Navarro-Esbrí Joaquín , Mota-Babiloni Adrián , Barragán-Cervera Ángel , Domenech Luis , Sánchez Fernando , Maiorino Angelo , Aprea Ciro
Published: September 2019

Phase change materials (PCMs) can be used in refrigeration systems to redistribute the thermal load. The main advantages of the overall system are a more stable energy performance, energy savings, and the use of the off-peak electric tariff. This paper proposes, models, tests, and analyzes an experimental water vapor compression chiller connected to a PCM thermal energy storage (TES) tank that acts as an alternative heat sink. First, the transient model of the chiller-PCM system is proposed and validated through experimental data directly measured from a test bench where the PCM TES tank is connected to a vapor compression-based chiller. A maximum deviation of 1.2 °C has been obtained between the numerical and experimental values of the PCM tank water outlet temperature. Then, the validated chiller-PCM system model is used to quantify (using the coefficient of performance, COP) and to analyze its energy performance and its dependence on the ambient temperature. Moreover, electrical energy saving curves are calculated for different ambient temperature profiles, reaching values between 5% and 15% taking the experimental system without PCM as a baseline. Finally, the COP of the chiller-PCM system is calculated for different temperatures and use scenarios, and it is compared with the COP of a conventional aerothermal chiller to determine the switch ambient temperature values for which the former provides energy savings over the latter.
A Neural Network-Based Model Reference Control Architecture for Oscillation Damping in Interconnected Power System
Authors: Uddin Waqar , Zeb Nadia , Zeb Kamran , Ishfaq Muhammad , Khan Imran , Ul Islam Saif , Tanoli Ayesha , Haider Aun , Kim Hee-Je , Park Gwan-Soo
Published: September 2019

In this paper, a model reference controller (MRC) based on a neural network (NN) is proposed for damping oscillations in electric power systems. Variation in reactive load, internal or external perturbation/faults, and asynchronization of the connected machine cause oscillations in power systems. If the oscillation is not damped properly, it will lead to a complete collapse of the power system. An MRC base unified power flow controller (UPFC) is proposed to mitigate the oscillations in 2-area, 4-machine interconnected power systems. The MRC controller is using the NN for training, as well as for plant identification. The proposed NN-based MRC controller is capable of damping power oscillations; hence, the system acquires a stable condition. The response of the proposed MRC is compared with the traditionally used proportional integral (PI) controller to validate its performance. The key performance indicator integral square error (ISE) and integral absolute error (IAE) of both controllers is calculated for single phase, two phase, and three phase faults. MATLAB/Simulink is used to implement and simulate the 2-area, 4-machine power system.
Emerging Stakeholder Relations in Participatory ICT Design: Renegotiating the Boundaries of Sociotechnical Innovation in Forest Biosecurity Surveillance
Authors: Grant Andrea , Pawson Stephen M. , Marzano Mariella
Published: September 2019

Research Highlights: This research advanced understanding of stakeholder relations within the context of innovation using citizen science in a biosecurity sociotechnical system (STS) in Aotearoa, New Zealand. Background and Objectives: It draws on recent experiences in the United Kingdom, where analysis of stakeholder engagement in the development of biosecurity surveillance technologies and citizen science initiatives have occurred to support understanding and development of forest and tree health biosecurity. Early detection technologies are essential as biosecurity risks to the primary sectors increase with the expansion of global trade and shifting pest dynamics that accompany a changing climate. Stakeholder engagement in technology development improves the chances of adoption but can also challenge the mental models of users in an existing STS. Materials and Methods: Two conceptual models that embed stakeholder relations in new information and communications technology (ICT) design and development were applied: (i) a future realist view of the general surveillance system incorporating citizen experts as species identifiers; (ii) a social construction of the ICT platform to surface mental models of the system in use creating the groundwork for evolution of stakeholder relations within STS innovation. A case study demonstrating how we addressed some of the practical limitations of a proposed systems change by applying sociotechnical innovation systems (STIS) theory to the development and adoption of new technologies for surveillance in the existing biosecurity system was presented. Results: Opportunities to enhance the capacity for early detection were considered, where the needs of diverse factors within a central government biosecurity authority and the wider citizenry are supported by the development of a general surveillance network (GSN).
The Prevalence and Clinical Characteristics of TECTA-Associated Autosomal Dominant Hearing Loss
Authors: Yasukawa Rika , Moteki Hideaki , Nishio Shin-ya , Ishikawa Kotaro , Abe Satoko , Honkura Yohei , Hyogo Misako , Mihashi Ryota , Ikezono Tetsuo , Shintani Tomoko , Ogasawara Noriko , Shirai Kyoko , Yoshihashi Hiroshi , Ishino Takashi , Otsuki Koshi , Ito Tsukasa , Sugahara Kazuma , Usami Shin-ichi
Published: September 2019

TECTA is well known as a causative gene for autosomal dominant mid-frequency hearing loss observed in various populations. In this study, we performed next-generation sequencing analysis of a large Japanese hearing loss cohort, including eight hundred and twelve (812) subjects from unrelated autosomal dominant hearing loss families, to estimate the prevalence and phenotype-genotype correlations in patients with TECTA mutations. The prevalence of TECTA mutations in Japanese autosomal dominant sensorineural hearing loss families was found to be 3.2%. With regard to the type of hearing loss, the patients with mutations in the nidogen-like domain or ZA domain of TECTA showed varied audiograms. However, most of the patients with mutations in the ZP domain showed mid-frequency hearing loss. The rate of hearing deterioration in TECTA-associated hearing loss patients and in the normal hearing Japanese control population were the same and regression lines for each group were parallel. We carried out haplotype analysis for four families which had one recurring missense variant, c.5597C>T (p.Thr1866Met). Our results revealed four different haplotypes, suggesting that this mutation occurred independently in each family. In conclusion, TECTA variants represent the second largest cause of autosomal dominant sensorineural hearing loss in Japan. The hearing loss progression observed in the patients with TECTA mutations might reflect presbycusis. The c.5597C>T mutation occurred in a mutational hot spot and is observed in many ethnic populations.
A Qualitative Study Examining Parental Involvement in Youth Sports over a One-Year Intervention Program
Authors: Lisinskiene Ausra , Lochbaum Marc
Published: September 2019

The purpose of this 12-month intervention program was to examine parent–child relationship changes within the sports context. A qualitative interpretative phenomenological analysis was used for the study design. Ten families consented to in-depth interviews. The participants were 10 youth sport parents who had one child each aged 5–6 years. The intervention program involved the participation of all the parents and children. The program integrated psychological, educational, and sports skills into pre-organized sports training sessions. The study results revealed that the intervention program had a positive impact on the parent–child relationship in the sports context. Additionally, the study results suggest that parental involvement in the intervention program positively affected parent–child attachment, the quality of interpersonal relationships between the parent and the child, and effective parenting strategies. Future intervention programs should include both parent and children dyads.
From Physical to Spiritual: A Qualitative Study of Jakartans Health & Sickness
Authors: Sokang Yasinta Astin , Westmaas Alvin Henry , Kok Gerjo
Published: September 2019

Understanding the perceptions of health and sickness can help the government, health providers and health promoters encourage individuals to participate in healthy behaviors and to follow a healthy lifestyle. Jakarta, the capital city of Indonesia, is a culturally, socially and financially diverse city, with complex health care needs. As yet, there is no published data available about Jakartans’ (i.e., the citizens of Jakarta city) perceptions on health and sickness. This study aimed to describe what health and sickness mean to Jakartans. To this means, we collected data using an open-ended survey about the meanings of health and sickness from 640 Jakartans. Five main themes of health and sickness emerged. The five themes of health were health as a physical condition, a psychological condition, a spiritual condition, a capability to carry out daily activities, and a healthy lifestyle. The themes regarding sickness were sickness as a physical condition, a psychological condition, an abnormal circumstance or bad situations, a spiritual condition, and an inability to carry out daily activities. We discussed how the above-mentioned perceptions might influence the daily health-related behaviors of Jakartans. In contrast to the typical biomedical approach, we found that, in Jakarta, health was not merely seen as a causal effect of the physical world. Further details are discussed.
Owners’ Attitudes toward Their Companion Dogs Are Associated with the Owners’ Depression Symptoms—An Exploratory Study in South Korea
Authors: Min Kyung-Duk , Kim Woo-Hyun , Cho Seongbeom , Cho Sung-il
Published: September 2019

Background: Various health benefits from the ownership of companion dogs have been studied from a One Health perspective. However, the preventive effects on depression are unclear, with inconsistent results across studies. We hypothesized that heterogeneity among owners would be related to the mixed results. Specifically, the difference in the strength of the bond between the owners and their companion dogs would modify the effect of dog ownership. As an exploratory study, we compared the depression symptoms of the owners with favorable attitudes toward their dogs, with those of the owners with unfavorable attitudes, to investigate the potential effect modification of owners’ attitudes on the association between the ownership and depression symptom. Methods: We conducted a web-based questionnaire survey of 654 19- to 39-year-old adults who had companion dogs in Seoul, South Korea, where a major health burden is depression among young adults. We measured the owners’ attitudes toward their dogs using the modified Pet Attitude Scale (PAS-M) and their depression symptoms using the short version of the Center for Epidemiologic Studies depression scale (CESD-10). Demographic and socioeconomic factors were measured to adjust for the association between attitude and depression symptoms. Multivariate logistic regression models were used in this study. Results: The owners who had less favorable attitudes toward their dogs (lower PAS-M scores) tended to have depression symptoms. The direction and significance were maintained either when the PAS-M variable was used as a continuous variable (odds ratio (OR) for one score increase in PAS-M was 0.95 (95% confidence interval (CI) = 0.94–0.96)) or as a categorical variable (OR for lower PAS-M was 3.19 (95% CI = 2.28 –4.47)). Conclusion: We found a positive significant association between owners’ depression symptoms and unfavorable attitudes toward their dogs, although causal direction could not be determined. Future studies should investigate the potential causal link.
Incidence and Risk Factors of Pre-Eclampsia in the Paropakar Maternity and Women’s Hospital, Nepal: A Retrospective Study
Authors: Das Seema , Das Rupesh , Bajracharya Rashmita , Baral Gehanath , Jabegu Bina , Odland Jon Øyvind , Odland Maria Lisa
Published: September 2019

This study aims to determine the incidence of pre-eclampsia and distribution of risk factors of pre-eclampsia at Paropakar Maternity and Women’s Hospital, Kathmandu, Nepal. A retrospective study included 4820 pregnant women from 17 September to 18 December 2017. Data were obtained from the medical records of the hospital’s Statistics Department. Associations between the risk factors and pre-eclampsia were determined using logistic regression analysis and expressed as odds ratios. The incidence rate of pre-eclampsia in the study population was 1.8%. Higher incidence of pre-eclampsia was observed for women older than 35 years (Adjusted Odds Ratio, AOR)= 3.27; (Confidence Interval, CI 1.42–7.52) in comparison to mothers aged 20–24 years, primiparous women (AOR = 2.12; CI 1.25–3.60), women with gestational age less than 37 weeks (AOR = 3.68; CI 2.23–6.09), twins pregnancy (AOR = 8.49; CI 2.92–24.72), chronic hypertension (AOR = 13.64; CI 4.45–41.81), urinary tract infection (AOR = 6.89; CI 1.28–36.95) and gestational diabetes (AOR = 11.79; CI 3.20–43.41). Iron and calcium supplementation appear to be protective. Age of the mothers, primiparity, early gestational age, twin pregnancy, chronic hypertension, urinary tract infection and gestational diabetes were the significant risk factors for pre-eclampsia. Iron and calcium supplementation and young aged women were somewhat protective.
DNA Copy Number Variations as Markers of Mutagenic Impact
Authors: Hovhannisyan Galina , Harutyunyan Tigran , Aroutiounian Rouben , Liehr Thomas
Published: September 2019

DNA copy number variation (CNV) occurs due to deletion or duplication of DNA segments resulting in a different number of copies of a specific DNA-stretch on homologous chromosomes. Implications of CNVs in evolution and development of different diseases have been demonstrated although contribution of environmental factors, such as mutagens, in the origin of CNVs, is poorly understood. In this review, we summarize current knowledge about mutagen-induced CNVs in human, animal and plant cells. Differences in CNV frequencies induced by radiation and chemical mutagens, distribution of CNVs in the genome, as well as adaptive effects in plants, are discussed. Currently available information concerning impact of mutagens in induction of CNVs in germ cells is presented. Moreover, the potential of CNVs as a new endpoint in mutagenicity test-systems is discussed.
Comparative Proteomics of Salt-Tolerant and Salt-Sensitive Maize Inbred Lines to Reveal the Molecular Mechanism of Salt Tolerance
Authors: Chen Fenqi , Fang Peng , Peng Yunling , Zeng Wenjing , Zhao Xiaoqiang , Ding Yongfu , Zhuang Zelong , Gao Qiaohong , Ren Bin
Published: September 2019

Salt stress is one of the key abiotic stresses that causes great loss of yield and serious decrease in quality in maize (Zea mays L.). Therefore, it is very important to reveal the molecular mechanism of salt tolerance in maize. To acknowledge the molecular mechanisms underlying maize salt tolerance, two maize inbred lines, including salt-tolerant 8723 and salt-sensitive P138, were used in this study. Comparative proteomics of seedling roots from two maize inbred lines under 180 mM salt stress for 10 days were performed by the isobaric tags for relative and absolute quantitation (iTRAQ) approach. A total of 1056 differentially expressed proteins (DEPs) were identified. In total, 626 DEPs were identified in line 8723 under salt stress, among them, 378 up-regulated and 248 down-regulated. There were 473 DEPs identified in P138, of which 212 were up-regulated and 261 were down-regulated. Venn diagram analysis showed that 17 DEPs were up-regulated and 12 DEPs were down-regulated in the two inbred lines. In addition, 8 DEPs were up-regulated in line 8723 but down-regulated in P138, 6 DEPs were down-regulated in line 8723 but up-regulated in P138. In salt-stressed 8723, the DEPs were primarily associated with phenylpropanoid biosynthesis, starch and sucrose metabolism, and the mitogen-activated protein kinase (MAPK) signaling pathway. Intriguingly, the DEPs were only associated with the nitrogen metabolism pathway in P138. Compared to P138, the root response to salt stress in 8723 could maintain stronger water retention capacity, osmotic regulation ability, synergistic effects of antioxidant enzymes, energy supply capacity, signal transduction, ammonia detoxification ability, lipid metabolism, and nucleic acid synthesis. Based on the proteome sequencing information, changes of 8 DEPs abundance were related to the corresponding mRNA levels by quantitative real-time PCR (qRT-PCR). Our results from this study may elucidate some details of salt tolerance mechanisms and salt tolerance breeding of maize.
In Vitro Evaluation of Novel Hybrid Cooperative Complexes in a Wound Healing Model: A Step Toward Improved Bioreparation
Authors: D’Agostino Antonella , Maritato Rosa , La Gatta Annalisa , Fusco Alessandra , Reale Sabrina , Stellavato Antonietta , Pirozzi Anna , De Rosa Mario , Donnarumma Giovanna , Schiraldi Chiara
Published: September 2019

The effectiveness of hyaluronic acid (HA), also called as hyaluronan, and its formulations on tissue regeneration and epidermal disease is well-documented. High-molecular-weight hyaluronan (HHA) is an efficient space filler that maintains hydration, serves as a substrate for proteoglycan assembly, and is involved in wound healing. Recently, an innovative hybrid cooperative complex (HCC) of high- and low-molecular-weight hyaluronan was developed that is effective in wound healing and bioremodeling. The HCC proposed here consisted of a new formulation and contained 1.6 ± 0.1 kDa HHA and 250 ± 7 kDa LHA (low molecular weight hyaluronic acid). We investigated the performance of this HCC in a novel in vitro HaCaT (immortalized human keratinocytes)/HDF (human dermal fibroblast) co-culture model to assess its ability to repair skin tissue lesions. Compared to linear HA samples, HCC reduced the biomarkers of inflammation (Transforming Growth Factor-β (TGF-β), Tumor Necrosis Factor receptor-α (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8)), and accelerated the healing process. These data were confirmed by the modulation of metalloproteases (MMPs) and elastin, and were compatible with a prospectively reduced risk of scar formation. We also examined the expression of defensin-2, an antimicrobial peptide, in the presence of hyaluronan, showing a higher expression in the HCC-treated samples and suggesting a potential increase in antibacterial and immunomodulatory functions. Based on these in vitro data, the presence of HCC in creams or dressings would be expected to enhance the resolution of inflammation and accelerate the skin wound healing process.
Effect of Saliva Collection Methods on the Detection of Periodontium-Related Genetic and Epigenetic Biomarkers—A Pilot Study
Authors: Han Pingping , Ivanovski Sašo
Published: September 2019

Different collection methods may influence the ability to detect and quantify biomarker levels in saliva, particularly in the expression of DNA/RNA methylation regulators of several inflammations and tissue turnover markers. This pilot study recruited five participants and unstimulated saliva were collected by either spitting or drooling, and the relative preference for each method was evaluated using a visual analogue scale. Subsequently, total RNA, gDNA and proteins were isolated using the Trizol method. Thereafter, a systematic evaluation was carried out on the potential effects of different saliva collection methods on periodontium-associated genes, DNA/RNA epigenetic factors and periodontium-related DNA methylation levels. The quantity and quality of DNA and RNA were comparable from different collection methods. Periodontium-related genes, DNA/RNA methylation epigenetic factors and periodontium-associated DNA methylation could be detected in the saliva sample, with a similar expression for both methods. The methylation of tumour necrosis factor-alpha gene promoter from drooling method showed a significant positive correlation (TNF α, r = 0.9) with clinical parameter (bleeding on probing-BOP). In conclusion, the method of saliva collection has a minimal impact on detecting periodontium-related genetic and epigenetic regulators in saliva. The pilot data shows that TNF α methylation may be correlated with clinical parameters.
Arabidopsis NDL-AGB1 modules Play Role in Abiotic Stress and Hormonal Responses Along with Their Specific Functions
Authors: Katiyar Arpana , Mudgil Yashwanti
Published: September 2019

Arabidopsis N-MYC Downregulated Like Proteins (NDLs) are interacting partners of G-Protein core components. Animal homologs of the gene family N-myc downstream regulated gene (NDRG) has been found to be induced during hypoxia, DNA damage, in presence of reducing agent, increased intracellular calcium level and in response to metal ions like nickel and cobalt, which indicates the involvement of the gene family during stress responses. Arabidopsis NDL gene family contains three homologs NDL1, NDL2 and NDL3 which share up to 75% identity at protein level. Previous studies on NDL proteins involved detailed characterization of the role of NDL1; roles of other two members were also established in root and shoot development using miRNA knockdown approach. Role of entire family in development has been established but specific functions of NDL2 and NDL3 if any are still unknown. Our in-silico analysis of NDLs promoters reveled that all three members share some common and some specific transcription factors (TFs) binding sites, hinting towards their common as well as specific functions. Based on promoter elements characteristics, present study was designed to carry out comparative analysis of the Arabidopsis NDL family during different stages of plant development, under various abiotic stresses and plant hormonal responses, in order to find out their specific and combined roles in plant growth and development. Developmental analysis using GUS fusion revealed specific localization/expression during different stages of development for all three family members. Stress analysis after treatment with various hormonal and abiotic stresses showed stress and tissue-specific differential expression patterns for all three NDL members. All three NDL members were collectively showed role in dehydration stress along with specific responses to various treatments. Their specific expression patterns were affected by presence of interacting partner the Arabidopsis heterotrimeric G-protein β subunit 1 (AGB1). The present study will improve our understanding of the possible molecular mechanisms of action of the independent NDL–AGB1 modules during stress and hormonal responses. These findings also suggest potential use of this knowledge for crop improvement.
Photonic Therapy in Periodontal Diseases an Overview with Appraisal of the Literature and Reasoned Treatment Recommendations
Authors: Giannelli Marco , Lasagni Massimo , Bani Daniele
Published: September 2019

Recent reviews and meta-analyses of the literature over the past quarter-century have failed to provide enough evidence to prove or disprove the actual utility of photonic therapy in periodontitis, alone or adjunctive to conventional approaches. This apparent paradox has been explained by the many physical, molecular, biological, anatomical, and technical variables of photonic treatments, which can differ in light-emitting devices (laser or LED), wavelengths, irradiation power and modes, clinical objectives, follow-up times, disease grading, and assessment methods. This multi-faceted, controversial scenario has led practitioners to underestimate the actual potential of photonic therapy in periodontal diseases. In this critical appraisal of the literature, we have briefly summarized the main photonic therapies and instruments used in Periodontology, highlighting their main characteristics and limitations. Then, we have tried to identify and discuss the key methodological issues which can have an impact on the outcome of photonic therapies. Our main goal was to identify the best parameters, settings, and methodologies to perform effective periodontal photonic treatments and to extrapolate some recommendations for clinical use. Should these recommendations find a consensus among periodontologists and be adopted in future clinical studies, they will hopefully contribute to dissipate the present confusion and uncertainty on this complex matter.
Evaluation of Monitoring Traps and Lures for Drosophila suzukii (Diptera: Drosophilidae) in Berry Plantings in Florida
Authors: Harmon Dasia S. , Haseeb Muhammad , Kanga Lambert H. B. , Liburd Oscar E.
Published: September 2019

Drosophila suzukii (Diptera: Drosophilidae) is an invasive insect pest that was detected in Florida in August 2009 in Hillsborough County. Very limited information is available for berry growers to properly detect and monitor this serious pest in southern highbush blueberry (hybrids of Vaccinium corymbosum L. × V. darrowi Camp), rabbiteye blueberry (Vaccinium virgatum L.), and blackberry (Rubus fruticosus L.) production systems. We compared several D. suzukii traps and lures/baits at two sites in Florida. The traps evaluated included Trécé, Scentry, and a standard homemade cup trap. These traps were compared with various baits and lures, including Trécé lure, Scentry lure, yeast bait, and Suzukii trap, under Florida production systems. Early detection is important to develop an effective monitoring system so management action can be taken before economic damage occurs. Data were recorded as overall trends, as well as in 4–5 trapping periods from early to late season. Overall, the Scentry trap baited with Scentry lure, the Trécé trap baited with Trécé lure + yeast, and the Trécé trap baited with Scentry lure were the best performing traps. Yeast-based traps were also attractive to D. suzukii early in the season, but they did not provide consistent captures as the season progressed. The Scentry trap with yeast bait, the Scentry trap with Scentry lure, the Trécé trap with Trécé lure + yeast bait, and a cup trap with yeast bait caught most of the flies during the first trapping period in 2015 and 2016 in the rabbiteye blueberry. In the southern highbush blueberry, the population of D. suzukii was much lower than in the rabbiteye blueberry planting, and the Scentry trap with Scentry lure captured the highest number of flies during the first trapping period in 2016. In the blackberry, the Scentry trap with Scentry lure numerically had the highest captures during the first trapping period, but this was not significantly different from the cup trap with yeast bait, the Trécé trap baited with Suzukii trap, and the Trécé trap with Trécé lure. Overall, the Scentry trap with Scentry lure was the most consistent trap that captured D. suzukii flies throughout the season in the three production systems—rabbiteye blueberry, southern highbush blueberry, and blackberry. Growers in low pressure systems that are similar to Florida can use the Scentry trap with Scentry lure to monitor D. suzukii populations.
General Anesthetic Agents and Renal Function after Nephrectomy
Authors: Lee Ho-Jin , Bae Jinyoung , Kwon Yongsuk , Jang Hwan Suk , Yoo Seokha , Jeong Chang Wook , Kim Jin-Tae , Kim Won Ho
Published: September 2019

The association between the choice of general anesthetic agents and the risk of acute kidney injury (AKI) and long-term renal dysfunction after nephrectomy has not yet been evaluated. We reviewed 1087 cases of partial or radical nephrectomy. The incidence of postoperative AKI, new-onset chronic kidney disease (CKD) and CKD upstaging were compared between general anesthetic agent groups (propofol, sevoflurane, and desflurane). Four different propensity score analyses were performed to minimize confounding for each pair of comparison (propofol vs. sevoflurane; propofol vs. desflurane; sevoflurane vs. desflurane; propofol vs. volatile agents). Study outcomes were compared before and after matching. Kaplan-Meier survival curve analysis was performed to compare renal survival determined by the development of new-onset CKD between groups up to 36 months after nephrectomy. Propofol was associated with a lower incidence of AKI (propofol 23.2% vs. sevoflurane 39.5%, p = 0.004; vs. propofol 21.0% vs. desflurane 34.3%, p = 0.031), a lower incidence of CKD upstaging (propofol 27.2% vs. sevoflurane 58.4%, p < 0.001; propofol 32.4% vs. desflurane 48.6%, p = 0.017) and better three-year renal survival after nephrectomy compared to sevoflurane or desflurane group (Log-rank test propofol vs. sevoflurane p < 0.001; vs. desflurane p = 0.015) after matching. Propofol was also associated with a lower incidence of new-onset CKD after nephrectomy compared to sevoflurane after matching (p < 0.001). There were no significant differences between sevoflurane and desflurane. However, subgroup analysis of partial nephrectomy showed a significant difference only in CKD upstaging. In conclusion, propofol, compared to volatile agents, could be a better general anesthetic agent for nephrectomy to attenuate postoperative renal dysfunction. However, limitations of the retrospective study design and inconsistent results of the subgroup analysis preclude firm conclusions.
The Ethical Consumer and Codes of Ethics in the Fashion Industry
Authors: Cerchia Rossella Esther , Piccolo Katherine
Published: September 2019

Sustainability is a central challenge of the fashion industry. In an era where Internet and social networks allow information to spread quickly, more consumers are familiar with the call for “ethical fashion” as disasters such as Rana Plaza resound worldwide. However, consumers interested in buying “ethical” clothing could have a hard time orienting themselves amongst the abundance of brands claiming to be ethical on the market. Consumers might make purchasing decisions based on their knowledge of a brand. In this context, it is imaginable that corporate social responsibility (CSR) communications, including codes of ethics, could constitute one way a consumer can learn more about a company’s values. These codes may serve a variety of purposes—they are undoubtedly one of the ways a brand communicates its commitment to ethical principles. Indeed, by analyzing the codes of ethics of some of the industry’s well-known brands, it is evident that they primarily focus on employment and workers’ rights (including equality and discrimination issues), labor safety standards, bribery and anti-corruption, counterfeiting and unfair business practices, as well as respect for (and sometimes improvement of) the environment. A company’s code of ethics is also a powerful tool for improving brand image by adopting a code that responds to the issues that consumers care about. It is therefore necessary to distinguish between companies that are truly ethical and those that merely appear so. In order to protect consumer confidence in such documents, a fil rouge across legal systems may be found (although the specific characteristics may vary greatly) in the laws that protect consumers from misleading advertising.
Bacterial Adhesion on Femtosecond Laser-Modified Polyethylene
Authors: Schwibbert Karin , Menzel Friederike , Epperlein Nadja , Bonse Jörn , Krüger Jörg
Published: September 2019

In this study, femtosecond laser-induced sub-micrometer structures are generated to modify polyethylene (PE) surface topographies. These surfaces were subjected to bacterial colonization studies with Escherichia coli and Staphylococcus aureus as test strains. The results reveal that the nanostructures do not influence S. aureus coverage, while the adhesion of E. coli is reduced.
Design and Manipulation of Ferroic Domains in Complex Oxide Heterostructures
Authors: Strkalj Nives , Gradauskaite Elzbieta , Nordlander Johanna , Trassin Morgan
Published: September 2019

The current burst of device concepts based on nanoscale domain-control in magnetically and electrically ordered systems motivates us to review the recent development in the design of domain engineered oxide heterostructures. The improved ability to design and control advanced ferroic domain architectures came hand in hand with major advances in investigation capacity of nanoscale ferroic states. The new avenues offered by prototypical multiferroic materials, in which electric and magnetic orders coexist, are expanding beyond the canonical low-energy-consuming electrical control of a net magnetization. Domain pattern inversion, for instance, holds promises of increased functionalities. In this review, we first describe the recent development in the creation of controlled ferroelectric and multiferroic domain architectures in thin films and multilayers. We then present techniques for probing the domain state with a particular focus on non-invasive tools allowing the determination of buried ferroic states. Finally, we discuss the switching events and their domain analysis, providing critical insight into the evolution of device concepts involving multiferroic thin films and heterostructures.
Study of Optical Properties of Surface Layers Produced by Laser Surface Melting and Laser Surface Nitriding of Titanium Alloy
Authors: Lisiecki Aleksander
Published: September 2019

This study measured optical properties, such as specular, diffuse, and total reflection for 808 nm wavelength, characteristic for high power diode lasers radiation, from the surface of titanium alloy Ti6Al4V at delivery conditions, polished, and oxidized. Moreover, the optical properties of surface layers produced by high power direct diode laser (HPDDL) melting and nitriding were determined. Additionally, a methodology for determining the value of absorption for 808 nm wavelength of the HPDDL radiation on the surface of a melt pool during laser surface melting and nitriding of titanium alloy was proposed. The results show that the distinct differences in absorption affect the heat transfer, thermal conditions of laser heating and thereby the penetration depth during laser melting and nitriding of the titanium alloy.
Evaluation of the Immunomodulatory Effects of Fucoidan Derived from Cladosiphon Okamuranus Tokida in Mice
Authors: Tomori Makoto , Nagamine Takeaki , Miyamoto Tomofumi , Iha Masahiko
Published: September 2019

Okinawa mozuku (Cladosiphon okamuranus Tokida) is an edible seaweed classified as brown algae and is a native species of the Ryukyu Islands in Japan. In recent years, the genomic decoding of Okinawa mozuku has been completed. Previous studies on the anti-inflammatory, antiviral, and antitumor properties of Okinawa mozuku have suggested that it affects the regulation of cellular and humoral immunity. The aim of the present study was to examine the immunoregulatory effect of fucoidan derived from Okinawa mozuku in mice. A product containing fucoidan (purity, 88.3%; molecular weight, 49.8 kDa) was developed from Okinawa mozuku and tested for its immunoregulatory effects in mice. The experimental animals were 8-week-old female BALB/c mice to which fucoidan (0, 102.5, 205.0, 410.0, and 1025.0 mg/kg) was administered orally continuously for six weeks. Immune cell proliferation, cytokine production, macrophage phagocytosis, and serum antibody concentration were measured. We found that immune cell proliferation, interleukin (IL)-2, macrophage phagocytes, and serum antibodies (IgM, -G, -A) increased significantly, but IL-4, -5, and IgE decreased significantly. These results indicated that fucoidan modulated cellular and humoral immunity.
Leaching and Selective Recovery of Cu from Printed Circuit Boards
Authors: Sethurajan Manivannan , van Hullebusch Eric D.
Published: September 2019

Printed circuit boards (PCBs), a typical end-of-life electronic waste, were collected from an E-waste recycling company located in the Netherlands. Cu and precious metal concentration analyses of the powdered PCBs confirm that the PCBs are multimetallic in nature, rich, but contain high concentrations of Cu, Au, Ag, Pd, and Pt. Ferric sulfate concentration (100 mM), agitation speed (300 rpm), temperature (20 °C), and solid-to-liquid ratio (10 g·L−1) were found to be the optimum conditions for the maximum leaching of Cu from PCBs. The ferric sulfate leachates were further examined for selective recovery of Cu as copper sulfides. The important process variables of sulfide precipitation, such as lixiviant concentration and sulfide dosage were investigated and optimized 100 ppm of ferric sulfate and (copper:sulfide) 1:3 molar ratio, respectively. Over 95% of the dissolved Cu (from the multimetallic leachates) was selectively precipitated as copper sulfide under optimum conditions. The characterization of the copper sulfide precipitates by SEM-EDS analyses showed that the precipitates mainly consist of Cu and S. PCBs can thus be seen as a potential secondary resource for copper.
Balancing Porosity and Mechanical Properties of Titanium Samples to Favor Cellular Growth against Bacteria
Authors: Civantos Ana , Beltrán Ana M. , Domínguez-Trujillo Cristina , Garvi Maria D. , Lebrato Julián , Rodríguez-Ortiz Jose A. , García-Moreno Francisco , Cauich-Rodriguez Juan V. , Guzman Julio J. , Torres Yadir
Published: September 2019

Two main problems limit the success of titanium implants: bacterial infection, which restricts their osseointegration capacity; and the stiffness mismatch between the implant and the host cortical bone, which promotes bone resorption and risk of fracture. Porosity incorporation may reduce this difference in stiffness but compromise biomechanical behavior. In this work, the relationship between the microstructure (content, size, and shape of pores) and the antibacterial and cellular behavior of samples fabricated by the space-holder technique (50 vol % NH4HCO3 and three ranges of particle sizes) is established. Results are discussed in terms of the best biomechanical properties and biofunctional activity balance (cell biocompatibility and antibacterial behavior). All substrates achieved suitable cell biocompatibility of premioblast and osteoblast in adhesion and proliferation processes. It is worth to highlighting that samples fabricated with the 100–200 μm space-holder present better mechanical behavior—in terms of stiffness, microhardness, and yield strength—which make them a very suitable material to replace cortical bone tissues. Those results exposed the relationship between the surface properties and the race of bacteria and mammalian cells for the surface with the aim to promote cellular growth over bacteria.
The Microenvironment in Immobilized Enzymes: Methods of Characterization and Its Role in Determining Enzyme Performance
Authors: Bolivar Juan M. , Nidetzky Bernd
Published: September 2019

The liquid milieu in which enzymes operate when they are immobilized in solid materials can be quite different from the milieu in bulk solution. Important differences are in the substrate and product concentration but also in pH and ionic strength. The internal milieu for immobilized enzymes is affected by the chemical properties of the solid material and by the interplay of reaction and diffusion. Enzyme performance is influenced by the internal milieu in terms of catalytic rate (“activity”) and stability. Elucidation, through direct measurement of differences in the internal as compared to the bulk milieu is, therefore, fundamentally important in the mechanistic characterization of immobilized enzymes. The deepened understanding thus acquired is critical for the rational development of immobilized enzyme preparations with optimized properties. Herein we review approaches by opto-chemical sensing to determine the internal milieu of enzymes immobilized in porous particles. We describe analytical principles applied to immobilized enzymes and focus on the determination of pH and the O2 concentration. We show measurements of pH and [O2] with spatiotemporal resolution, using in operando analysis for immobilized preparations of industrially important enzymes. The effect of concentration gradients between solid particle and liquid bulk on enzyme performance is made evident and quantified. Besides its use in enzyme characterization, the method can be applied to the development of process control strategies.