bluuebunny/crossref_metadata_2025 huggingface dataset:
Theoretical calculations and molecular design of novel dioxoisoindoline derivatives as anticonvulsant agents
Authors:   Department of Chemistry, College of Education for Pure Sciences, University of Anbar, Ramadi, Anbar, Iraq, Ahmed Rawaa Mohammed , Ezza Mohammed Oday ,   Department of Chemistry, College of Education for Women, University of Anbar, Ramadi, Anbar, Iraq
Published: May 2024

Our study discusses the need for the development of alternative treatments for antiepileptic drugs. It proposes a theoretical chemical study using dioxoisoindoline derivatives and molecular docking in order to find potential alterna¬tive drugs. Three compounds (S1, S3, and S4) exhibited distinct activity against specific proteins related to epilepsy treatment. Our study also describes a DFT study that analysed the energy levels of the derivatives. Furthermore, we employed Lipinski’s rule and drug likeness predictions in order to assess the suitability of the derivatives as medicines. The results indicate that the molecular mass, log P, hydrogen bonding donors, and acceptors of the compounds fall within acceptable ranges. Overall, our study emphasizes the importance of finding new treatments for epilepsy, and presents a preliminary investigation into the potential of dioxoisoindoline derivatives.
Inorganic polymers as drug carriers: opportunities and challenges
Authors:   Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Divband Baharak ,   Inorganic Chemistry Department, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
Published: May 2024

Innovative methods and significant developments in designing new synthetic inorganic materials have been used to overcome limitations of current drug delivery systems. Inorganic polymers are widely used in the field of biomedicine, imaging, tissue engineering and drug delivery because of their bioactivity, biocompatibility, and stability. A few of the more well-known wholly inorganic polymers are portland cement, silicon dioxide, polyanionic glasses (including titania- and aluminosilicate glasses), poly(sulphur nitride), polycrystalline diamond, graphite, poly(sulphur nitride), and alumi¬num-silicate materials. Inorganic polymers, especially those possessing significant porosity, are good potential candi¬dates for the delivery of several drugs (anticancer, antibiotics, and anti-inflammatories), providing advantages such as encapsulation, controlled delivery, and improved targeting of drugs. Choosing a suitable drug carrier with a selec¬tive targeting potential also seems to be a very promising way for improving stability as well as selectivity. Despite all the advances, developing homogeneous inorganic polymers with narrow molecular weight distributions is a multidis¬ciplinary challenge. The current keynote speech provides a review of the opportunities and challenges of using inor¬ganic polymers as drug carriers.
Preparation and characterization of nanoparticles loaded with dimethyl fumarate for the treatment of multiple sclerosis
Authors:   Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Malaysia, A. Alhussein Abdulazeez Basim , Gaaz Tayser Sumer ,   Prosthetics and Orthotics Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Babylon, Iraq, Jaaz Ahed Hameed ,   Medical Physics Department, College of Science, Al-Mustaqbal University, Babylon, Iraq
Published: May 2024

When nanotechnology is used in medicine, it makes it easier to find and treat a wide range of diseases. One of the oral options for treating multiple sclerosis (MS) is dimethyl fumarate (DMF). DMF has been shown to be effective in lowering inflammatory diseases; nevertheless, it is characterized by several undesirable side effects that reduce pa¬tient compliance and add financial obstacles. The aim of this study was to use platelet membranes and platelet na¬noparticles to generate a drug delivery system that works like a cell, so as to treat MS. During the experiments, there is a chance that the DMF solution might harden at room temperature. Therefore, in order to produce solid lipid nano¬particles (SLNs), DMF was combined with biocompatible lipids. The creation of SLNs involved the use of hot emulsion and ultrasonication. These DMF-SLNs were characterized by means of scanning electron microscopy, and Fourier-transform infrared spectroscopy. The herein demonstrated enhanced qualities of the devised SLNs suggest that the formulation may be a potential, longer-acting formulation for the improved management of MS. SLNs could change the way many illnesses are treated in a big way, if they are used for the delivery of medicines.
Applications of quartz crystal microbalance with dissipation in nanomedicine (QCM-D): a personal experience
Authors:   School of Pharmacy and Pharmaceutical Sciences & School of Medicine, Trinity College Dublin, The University of Dublin, Ireland, Santos-Martinez Maria J.
Published: May 2024

Due to their unique physical and chemical properties, the potential application of nanomaterials in medicine is partic¬ularly attractive. Despite the many advantages that nanomaterials can offer as diagnostic and therapeutic tools, their transition from the bench to clinical practice is extremely challenging. One of the many barriers that nanomedicines may encounter is their toxicological effect. In fact, the development of novel nanomaterials / nanoparticles must pro¬ceed always in tandem with the assessment of any potential toxicological effects associated to them. Once nano¬materials reach the systemic circulation, they interact with endothelial cells, plasma proteins, and other blood compo¬nents. There is no doubt that the study of nanomaterials-blood interactions is crucial to warrant the biocompatibility of nanomaterials developed for human use.
Chronic nutritional deficit resulting in multiorgan disease presentations in remote Pakistan: case reviews from natural disaster settings
Authors:   Disaster Medicine and Dentistry Consultancy and Training Organization, Bradford, England, UK, Aslam Hadia
Published: May 2024

The aftermath of monsoon rains that fell in Pakistan from June to November 2022 were catastrophic as millions of people were affected, water systems were damaged, and agricultural production was affected. The floods aggravated the already existing nutrition crisis which largely increased children’s vulnerability. Disaster Medicine and Dentistry (DMD), a UK-registered consultancy organization, provided support to the affected households in Dera Ismail Khan through the provision of water pumps, food rations, and climate-resistant houses. It also established a mobile medical unit that provided medical services to affected households. All the children that came for consultation were far below the expected height or weight range for their age, thus showing signs of chronic malnutrition. They also presented with multiorgan diseases as a result of the chronic malnutrition, and DMD’s onsite and remote consultants managed them all. We took a wholistic approach to managing the nutrition crisis and the floods, which significantly improved the health outcomes of the affected individuals and households.
Preparation and characterization of azelnidipine-loaded D-α-tocopheryl polyethylene glycol succinate (TPGS) / solutol micelles
Authors:   Babylon Health Directorate, Hillah, Iraq, Ala Allah Ali Kathem , Abd Alhammid Shaimaa Nazar ,   Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq
Published: May 2024

Azelnidipine is a calcium-channel antagonist classified as a “class 2” drug with high permeability and low aqueous solubility. It is used in the treatment of angina pectoris and hypertension without reflex tachycardia. Improvement of the solubility of azelnidipine and increasing drug’s bioavailability can be achieved through the drug encapsulation in solutol / D-α-tocopheryl polyethylene glycol succinate (TPGS) micelles. Six formulas were prepared by direct disso¬lution after using different amounts of solutol and TPGS. TPGS and solutol act as solubilizers, permeation enhancers, and P-glycoprotein inhibitors. The particle size, particle size distribution, zeta potential, and entrapment efficiency were determined. Depending on particle size and entrapment efficiency, formula #6 was selected and subjected to in vitro dilution stability and in vitro release studies. The results obtained showed that formula #6 was the best formula, with a high entrapment efficiency percentage equal to 86.5%±0.58% and a small particle size equal to 21.9±7.75 nm that did not change significantly after dilution up to 100-fold; a fact that reveals the high thermodynamic and kinetic stability of the optimum formula. The formula #6 release profile showed a controlled release of the drug from micelles when compared to plain drug release. Based on these results, polymeric nanomicelles are regarded as a promising delivery system for azelnidipine.
Tackling obesity from a nanomedicine perspective
Authors:   School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin and Trinity St. James’s Cancer Institute, St James’s Hospital, Dublin, Ireland, Gobbo Oliviero L.
Published: May 2024

Obesity is a worldwide issue that is progressively worsening. It can result in significant co-morbidities, including type 2 diabetes, cardiovascular disease, and obesity-related cancers. Current treatment options for obesity have several limitations, and the connection between obesity and cancer development is not well comprehended. We examine the current state and future prospects of obesity therapy, with a focus on the potential application of nanomedicine. The presentation emphasizes the necessity for further research in this field and how developments in cancer therapy using nanomedicines could be applied for the treatment of obesity, thereby providing a safe and effective treatment with reduced side-effects for those patients.
The interaction of choline and one-carbon / folate metabolism derangements on the cardiac remodeling process with or without diabetes
Authors:   College of Pharmacy, University of Babylon, Hillah, Iraq, Liapi Charis ,   Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Published: May 2024

Proper nutrition helps protect from illness and disease. Choline (Ch), an essential molecule of substantial importance for the optimal development and function of several biological systems, plays a crucial role in the pathway of one-carbon metabolism. On the other hand, Ch-deprivation (CD) has been linked with abnormal fat metabolism, insulin resistance, and myocardial dysfunction. The Ch-deficiency setting is an established experimental model of non-alco¬holic steatohepatitis that resembles the human non-alcoholic fatty liver disease (NAFLD); a disease with constantly increasing incidence and prevalence. NAFLD, commonly associated with metabolic comorbidities such as obesity and type 2 diabetes mellitus, consists a high risk for cardiovascular disease. Experimental data of dietary CD through the administration of a Ch-deficient diet to rodents have revealed myocardial monocyte infiltration along with cardiac interstitial oedema and fibrosis, as well as a deleterious effect on cardiac valves that could lead to impaired heart mechanical properties which resemble to a restrictive pattern of cardiomyopathy characterised mainly by diastolic dysfunction. In a Ch-deprived diabetic experimental model, the diastolic heart failure has been characterized by a concentric hypertrophied myocardium, a left ventricular cavity with a thinner wall, and an increased left ventricular diastolic diameter, in addition to a left atrial dilatation that could also exert functional derangement and provoke arrhythmogenesis, thereby jeopardising cardiac output.
Assessment of antifungal drugs’ activity against some Candida albicans isolates in the presence or absence of human albumin: a study employing an in vitro pharmacokinetics / pharmacodynamics model
Authors:   Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon, Hillah, Iraq, Abdalwahd Noor ,   Department of Pharmacology, College of Medicine, University of Babylon, Hillah, Iraq, Al-Saigh Rafal J. ,   Department of Clinical Laboratory Sciences, College of Pharmacy, University of Babylon, Hillah, Iraq, Al-Humadi Hussam W. ,   College of Pharmacy, University of Babylon, Hillah, Iraq
Published: May 2024

Invasive candidiasis associated with the dissemination of endogenous Candida species is a fatal condition linked to high rates of morbidity and mortality. Progressive drug resistance necessitates the need for prompt and effective therapy. Therefore, choosing a specific and effective treatment is crucial. A two-compartment in vitro pharmacokinetics (PK) / pharmacodynamics (PD) model has been used for this purpose, and the PD behaviours of amphotericin B (AMB; at 2.5 and 5 mg/L), voriconazole (VOR; at 1.5 and 3 mg/L), and itraconazole (ITR; at 1.5 and 3 mg/L) were assessed against two Candida albicans isolates (a sensitive and resistant one; ATCC-90028 and ATCC-10231, re¬spectively) with or without the addition of human albumin (2%). PK were simulated as time-concentration profiles, while the PD susceptibility of all drug doses has been assessed through the minimum inhibitory concentration (MIC), the relative optical density of fungal growth, and the exposure - effect relationship (fAUC0–24/MIC). A fungicidal activity without the presence of albumin was seen against both isolates of C. albicans at the highest dose of VOR, while the addition of albumin potentiated the efficacies of AMB and of VOR against both isolates, with no effect for ITR. Finally, human albumin exerted a variable and dose-dependent effect on the activities of some antifungal agents.
The off-target NHE1 inhibitory effect of SGLT2 inhibitors in cardiac remodeling
Authors:   Department of Pharmacology, Faculty of Medicine & Dentistry, College of Health Sciences, University of Alberta, Edmonton, Canada, Mraiche Fatima
Published: May 2024

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors, approved for the treatment of diabetes mellitus, have gained attention for their cardioprotective effect. The exact mechanism by which SGLT-2 inhibitors exert their cardioprotective effect remains unclear. Recent studies have suggested that empagliflozin (EMPA), an SGLT inhibitor, exerts its car¬dioprotective effect by inhibiting the Na+/H+ exchanger (NHE); a group of membrane proteins that regulate intracel¬lular pH and cell volume. Increased activity and expression of NHE isoform 1 (NHE1), the predominant isoform ex¬pressed in the heart, leads to cardiac hypertrophy. Our research group investigates the indirect mechanisms by which SGLT inhibitors exert their cardioprotective effect and have demonstrated that angiotensin II (ANG)-induced hyper¬trophy of H9c2 cardiomyoblasts is accompanied with increased SGLT-1 and NHE1 protein expression; an effect which is reversed in the presence of EMPA. In addition, we demonstrated that dapagliflozin improved survival of transgenic mice expressing cardiac-specific NHE1.
The translational aspects of glucocorticoid biorhythmicity in modern therapeutics
Authors:   Faculty of Medicine & Dentistry (Malta campus), Queen Mary University of London, Victoria, Malta, Kalafatakis Konstantinos
Published: May 2024

Glucocorticoids are a class of steroid hormones, vital for mammalian life. They have a plethora of biological effects, mainly supporting metabolic, cognitive, and immunological functions. The pharmacological use of glucocorticoids makes them one of the most frequently prescribed drugs across all continents, and in all types of forms. Nevertheless, a number of serious adverse effects accompany the prolonged treatment with high doses of glucocorticoids. Research developments over the last 20 years have gradually reshaped the way we think about glucocorticoid-based therapeu¬tics. Aside their circadian rhythm and their delayed regulatory influence over an extensive number of sensitive genes, glucocorticoids also possess an underlying, ultradian rhythm, and also exert rapid, non-genomic effects. The notion that chronicity of glucocorticoid stimulation may differentially modulate the type of biological effects of the hormone brings various chronopharmacological concepts on the table of modern glucocorticoid-based therapeutics.
Antibiotic resistance of Bacillus species isolated in foodstuff samples that were collected in Babylon (Iraq)
Authors:   Department of Biology, College of Science, University of Babylon, Hillah, Iraq, Aladeli Hutham Abdulilah Amer , Althahab Azhar O. ,   Department of Biology, College of Science, University of Babylon, Hillah, Iraq, Jabuk Sura I. A. ,   Department of Biology, College of Science, University of Babylon, Hillah, Iraq
Published: May 2024

A total of 164 food samples were collected from various supermarkets and farmers in various areas of Babylon, were placed in plastic containers, and were transported to the laboratory. The isolation of Bacillus species was performed by culture in blood agar, chromogenic agar, and the absence of growth on McConkey agar, by staining with Gram stain, and through molecular identification of the species’ 16SrRNA gene and sequencing. The antibiotic susceptibility test used eight types of antibiotics. The undertaken sequencing identified the Bacillus isolates to belong to the follow¬ing species: B. subtilis (2), B. cereus (6), B. thuringiensis (1), B. anthracis (1), and B. spizizenii (1). The susceptibility test of the six B. cereus isolates revealed that 5 (83.3%), 4 (66.6%), 3 (50%), 2 (33.3%), 2 (33.3%), 2 (33.3%), 1 (16.6%), and 0 (0%) were resistant to rifampicin, clindamycin, erythromycin, tetracycline, trimethoprim, nitrofurantoin, gentamicin, and ciprofloxacin, while the respective resistance numbers for the two isolates of B. subtilis were 2 (100%), 2 (100%), 2 (100%), 0 (0%), 1 (50%), 0 (0%), 0 (0%), and 0 (0%). One isolate of B. thuringiensis presented resistance to erythromycin, erythromycin, trimethoprim, and rifampicin, while one isolate of B. anthracis was found to be resistant to gentamicin, erythromycin, nitrofurantoin, and rifampicin. The B. spizizenii isolate was resistant to all antibiotics except gentamicin and trimethoprim.
Network pharmacology speaking to ethnopharmacology: new data on an ancient remedy
Authors:   School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland, Liu Junying
Published: May 2024

Network pharmacology as a “green approach”, predicting metabolite behaviours chemically and biologically and guid¬ing biological experimental design, is a new strategy aiming to uncover the mechanism of action of natural products as drug candidates. It provides a powerful way to identify novel mechanisms of natural products with potential thera¬peutic effects. This approach has emerged as a powerful tool to overcome the limitations of traditional methods, such as the ability to predict the adverse effects of a drug and the likelihood of failure during clinical trials, by applying systems biology principles to the field of pharmacology. This method combines the multi-omics dataset, computer modeling, and chemical biology so as to reveal pharmaceutical actions and guide drug discovery. Therefore, computer-aided drug design combined with network pharmacology can be viewed as a novel in silico screening ap¬proach to drug discovery, by utilising chemoinformatics, bioinformatics, structure biology, and chemical biology. This strategy includes target-based virtual screening - molecular docking, ligand similarity-based virtual screening, and inverse screening (Inver-dock), providing a powerful tool for target identification of drug candidates, multitarget dis¬covery, and natural bioactive product profiling. It can also be used for selectivity profiling of drugs, drug repositioning, safety profiling, and metabolism profiling prediction (ADMET).
Exploring Titanium Dioxide Nanotubes: Pioneering Advanced Applications in Efficient Water Splitting and Sustainable Hydrogen Generation
Authors: Jeslin Jebish G P
Published: May 2024

This interdisciplinary study synthesizes findings from diverse fields including materials science, psychology, and environmental sustainability to explore the multifaceted challenges and opportunities associated with titanium dioxide (TiO2) nanotubes and social media use. In the realm of materials science, TiO2 nanotubes have garnered attention for their potential applications in sustainable energy generation, particularly in water splitting for hydrogen production. Synthesis methods such as hydrothermal synthesis and nitrogen doping have been investigated to enhance the photocatalytic performance and stability of TiO2 nanotubes. Concurrently, the proliferation of social media platforms has transformed communication patterns and behaviors worldwide, shaping individuals' interactions, perceptions, and mental health outcomes. While social media offers opportunities for connectivity and self-expression, excessive use has been associated with adverse mental health outcomes, including symptoms of depression, anxiety, and loneliness. Additionally, social media engagement has been linked to body image dissatisfaction, sleep disturbances, and academic performance, highlighting the complex interplays between online behaviors and psychological well-being. This study integrates insights from a comprehensive review of peer-reviewed literature, encompassing experimental research, observational studies, and survey-based investigations. The synthesis underscores the need for interdisciplinary collaboration and targeted interventions to address the complex societal challenges posed by TiO2 nanotubes and social media use. Recommendations include further research to optimize synthesis methods, enhance regulatory oversight, and promote responsible digital citizenship. By fostering dialogue and collaboration between researchers, policymakers, and practitioners, this study aims to inform evidence-based interventions and policy initiatives to promote sustainability, well-being, and equity in the digital age.
ROLE OF MODERATION OF THE INTERNAL CONTROL SYSTEMS OF THE GOVERNMENT TO STRENGTHEN THE IMPACT OF REGULATIONS ON THE SECURITY OF GOVERNMENT'S WORK AND SERVICES (LKPPS) TO THE ACCOUNTABILITY OF GOODS AND SERVICES (STUDY AT THE PROCUREMENT OFFICE OF BANTEN PROVINCE)
Authors: Elnanda Putri Elen , Zulfikar Rudi , Mulyadi Roza
Published: May 2024

The aim of this research is to determine the influence of regulations on the accountability of goods and services procurement at the Goods and Services Procurement Bureau in Banten Province and to find out whether the Government's Internal Control System can moderate regulations on the accountability of goods and services procurement at the Goods and Services Procurement Bureau in Banten Province. The analytical method used in this research is a quantitative method. The data collection method used a questionnaire with a total of 60 respondents. Data analysis in this research uses Partial Least Square analysis via SmartPLS 3.0 software. The results of statistical tests show that there is a positive and significant influence of Government Goods and Services Procurement Policy Institution Regulations on accountability, the Government Internal Control System can moderate and significant influence of Government Goods and Services Procurement Policy Institution regulations on accountability.
NON-CYCLICAL INDUSTRIAL PERFORMANCE IN INDONESIA: THE MODERATION OF AUDIT QUALITY
Authors: Hakim Mohamad Zulman , Daniel Rahandri  , Mochammad Farid Fadillah  , Siti Nurhaliza  , Aisyah Sholikhati  , Ika Wulandini
Published: May 2024

This study aims to analyze the factors of hexagon fraud in detecting financial statement fraud in non-cyclical sector companies listed on the Indonesia Stock Exchange (IDX) for the 2020-2022. Based on the purposive sampling method, the number of companies sampled in this study was 33 research criteria of non-cyclical companies with a total of 66 observations. The results of this study found that the element of pressure proxied by government projects had a significant effect on fraudulent financial statements. Meanwhile, financial targets, financial stability, changes in directors, ineffective monitoring, change in auditors, frequent number of CEO's pictures, political connections, state-owned enterprises, and audit opinions have no significant effect on fraudulent financial reports in non-cyclicals sector companies listed on the IDX 2020-2021.
FACTORS RELATED TO HYPERTENSION CONTROL IN THE ELDERLY AT PUSKESMAS BANTEN GIRANG YEAR 2024
Authors: Nita Nofita  , Ismarina  , Lukman Waris
Published: May 2024

Hypertension is still the most common health problem experienced by the world's population. Hypertension is a condition of a person who has systolic blood pressure ≥140 mmHg and diastolic pressure ≥90 mmHg. The high prevalence of hypertension in the elderly group is caused because with age, resulting in a decrease in physiological functions of the body, so that non-communicable diseases begin to appear. Hypertension control behavior is the main thing to prevent complications, such as stroke, coronary heart disease, and kidney failure. This study aims to determine the factors associated with elderly behavior in controlling hypertension. This type of research is quantitative with a cross sectional design. Independent variables are gender, education level, lifestyle. While the dependent variable is the control behavior of hypertension in the elderly. The population of all hypertensive patients recorded in the Banten Girang Health Center work area in 2023. The sample number of 100 people was selected by purposive random sampling. Statistical test using Chi square test with 95% CI and logistic regression test. The results of statistical tests showed that sex and education variables did not have a significant relationship with hypertension control behavior in the elderly (p > 0.05), while lifestyle variables with p = 0.003 OR = 4,902, and family support variables with p = 0.010 OR = 3,778 which means they have a meaningful relationship with hypertension control behavior in the elderly.
THE RELATIONSHIP BETWEEN THE PHYSICAL CONDITION OF THE HOME ENVIRONMENT AND HISTORY OF DISEASE WITH THE INCIDENCE OF TUBERCULOSIS IN THE WORKING AREA OF THE RANGKASBITUNG HEALTH CENTER IN 2023
Authors: Windarti  , Ismarina  , Marthia Ikhlasiah
Published: May 2024

This study aims to determine the relationship between the physical condition of the home environment and history of disease with the incidence of tuberculosis or pulmonary tuberculosis in the work area of the Rangkasbitung Health Center in 2023. This study is a descriptive correlation study with cross sectional design, which is research that explores the relationship between the physical condition of the house and the behavior of residents towards the incidence of tuberculosis. The type of data used is primary data, from the results of questionnaires and secondary data obtained from recording and reporting TB patient visit data at the Rangkasbitung Health Center. Data analysis in the study, using univariate analysis with positive TB incidence results (69.2%); Bivariate analysis showed a relationship between home air circulation and the incidence of tuberculosis (P<0.028), occupancy density (P<0.011), lighting (P<0.015), humidity (P<0.020), education (P<0.002), employment (P<0.006), and smoking (P<0.009); and humidity factor being the dominant factor with the largest OR (OR=28.579). The results of the cross-sectional test in the study, showed a significant relationship between the physical condition of the home environment and the history of disease with the incidence of tuberculosis in the work area of the Rangkasbitung Health Center. Suggestions in this study are the need for education related to environmental factors and behaviors that cause tuberculosis, such as counseling about healthy homes with qualified ventilation, good lighting, good humidity, occupancy in an adequate place, and reducing cigarette use habits. Other factors that need to be improved, in order to support the reduction in TB prevalence rates, namely education and employment factors. Patients with pulmonary tuberculosis must also be given understanding, related must always be tried to be in a place that has adequate air ventilation and good humidity, in order to reduce the risk of the severity of TB disease which can lead to death or the duration of the treatment process.
FACTORS RELATED TO THE INCIDENCE OF MEASLES IN CHILDREN AGED 12 – 59 MONTHS IN THE WORKING AREA OF THE TIRTAYASA HEALTH CENTER, SERANG REGENCY IN 2023
Authors: Ratnasati  , Lukman Waris  , Rita Ramayulis
Published: May 2024

This thesis aims to determine the factors related to the incidence of measles in the working area of the Tirtayasa Health Center, Serang Regency in 2023. The variables used consisted of independent variables consisting of: child factors (gender, measles immunization status, nutritional status, complete basic immunization status, status of high-dose vitamin A supplements), maternal factors (education level, level of knowledge, employment status, attitude), father factors (education level, employment status), environmental factors (occupancy density, house ventilation) and economic socialization factors (family income). The sample was mothers who had children aged 12 months to 59 months as many as 100 people and data was collected by distributing questionnaires. The results showed factors that were not associated with the incidence of measles: the sex of the child with a Pvalue of 0.427, the status of high-dose vitamin A supplementation with a Pvalue of 0.982, the employment status of the mother with a Pvalue of 0.950, and the employment status of the father with a Pvalue of 0.878. While the factors that are significantly related to the1 incidence of measles include: measles immunization status with Pvalue 0.000, nutritional status with Pvalue 0.026, maternal education level with Pvalue 0.000, maternal knowledge level with Pvalue 0.017, maternal attitude with Pvalue 0.006, father's education level towards with a Pvalue of 0.044,  a density of a house with a Pvalue of 0.02, home ventilation with  a Pvalue of 0.035 and family income against the incidence of measles Pvalue of 0.001. In accordance with the results of the study, the researchers' suggestions are: puskesmas officers to increase counseling, puskesmas to collaborate with other parties to improve the living environment and explore other variables for further researchers.
DISCLOSURE OF SUSTAINABILITY REPORT LEGITIMACY THEORY PERSPECTIVE
Authors: Filbert Kusuma Deharlie  , Aminah
Published: May 2024

This study aims to empirically ascertain how the Sustainability Report is influenced by company size, profitability, audit committee, and institutional shareholding. Sustainability Report internal and external responsibility of stakeholders to the performance of the organization in achieving sustainable development goals. This study determines the population of companies included in the List of Rating – Asia Sustainability Reporting Rating (ASRRAT) awards in 2022. Purposive sampling was used for the sampling process, resulting in 11 companies and 44 observations in total. Testing research results using multiple linear regression, classical assumption testing, descriptive statistical analysis, and hypothesis testing are all part of the data analysis approach. The findings show how the disclosure of the Sustainability Report is positively influenced by company size, profitability, audit committee, and institutional shareholding.
ANALYSIS OF MANAGEMENT STRATEGY IN FACING BUSINESS COMPETITION (CASE STUDY AT PT. TRIPUTRA LESTARI BANDAR LAMPUNG)
Authors: Dina Monika  , Habibburahman
Published: May 2024

By looking at the competition that occurs in the business industry today, in addition to prices, competition also occurs in services. This led to the management of the company PT. Triputra Lestari Bandar Lampung is challenged to strive competitively in the face of competitors. One of them is by analyzing the company's strategy. Strategy is a set of decisions and actions that result in the formulation and implementation of plans designed to achieve company goals. With information services through effective and efficient management able to offer to the market at competitive prices. This study aims to determine the analysis of strategy management in facing business competition and the implementation of its strategy. This research is qualitative research with a descriptive approach. The method used is a case study. While descriptive analysis is used to analyze data because the author of this study analyzed management methods at PT. Triputra Lestari Bandar Lampung in order to face business competition. The result achieved is that the company must contribute to local market research through the development of custom demineralizers, chemical watermen and sterilizer machines to ensure success and success in future business competition. There must be efforts to reduce environmental impact and comply with regulations that can improve the company's image in the eyes of consumers and other interested parties.
ANALYSIS OF CATFISH FARMING BUSINESS DEVELOPMENT STRATEGY IN FISH FARM AGRIBUSINESS KARANG SARI VILLAGE SOUTH LAMPUNG
Authors: Novan Ardiansyah  , Selfia Alkemega
Published: May 2024

Indonesia is one of the countries that has abundant resources both from capture fisheries production and aquaculture fisheries. Catfish farming has profitable potential because the demand from the community is very high, while judging from the cultivation technique is relatively simple and quite easy. This research was conducted by analyzing how the catfish farming business development strategy in the Fish Farm Fisheries Agribusiness business of Karang Sari Village, South Lampung. The purpose of this study is to find out the catfish business development strategy in the Fish Farm Fisheries Agribusiness, this analysis method uses a qualitative analysis method using SWOT analysis in SWOT analysis divided into two groups, namely internal factors (IFAS) consisting of strengths and weaknesses and external factors (EFAS) consisting of opportunities and Threat. Based on the Internal Factor Analysis Summary (IFAS), the completeness score of all internal components (Quality and deficiency) is 3.13, while for the External Factor Analysis Summary (EFAS), it is known that from each external factor (Openings and Hazards) is 3.14. The results of the study of the SWOT analysis diagram produced are that the growth strategy is in quadrant 1, then the strategy applied is a growth strategy (Growth).
Thriving or Declining? Unraveling Corruption, Environmental Quality, Energy Consumption, and Economic Growth in ASEAN Countries
Authors: Rehman Shafiq Ur
Published: May 2024

The current study is carried out to explore the link between Corruption,Environment quality. Energy consumption and economic growth in selectedAsean countries. In addition to that, the present study aims to highlight thedirect impacts of corruption upon environmental degradation, energyconsumption, and economic progress. For this purpose, the analyticalframework has been particularly used. Theoretically, environmental quality isexpected to be directly influenced by corruption using taxation andregulations, while corruption affects economic growth which in turn affectsthe quality of environment. Therefore, economic growth is negativelyinfluenced by the levels of corruptions. The higher the levels of corruption thelower will be the GDP level of an economy. This lower GDP level theninfluences the environmental quality, and thus confirms the EKC hypothesis.This paper has employed cointegration model for analyzing the associationbetween environmental quality, energy consumption, corruption, andeconomic growth for the data involving 5 ASEAN countries i.e. Malaysia,Thailand, Singapore, Philippines, and Indonesia for the years 1960-2021. Theliterature review has shown no empirical study that have employedcointegration model for examining the effects of corruption on energyconsumption, environmental quality, and economic growth. The findings ofthe study are in line with the proposed hypothesis. The study which is amongthe pioneering studies will be helpful for policymakers and researchers.
Optimalisasi Kemandirian dan Jiwa Interpeunership Santri: Inovasi Manajemen Peserta Didik di Pesantren Terpadu
Authors: Ridwan Mohammad , Nurrobiyanto Nurrobiyanto , Jahari Jaja , Erihadiana Mohamad
Published: May 2024

Penelitian ini mengeksplorasi optimalisasi kemandirian dan semangat kewirausahaan di kalangan santri pesantren melalui manajemen inovatif peserta didik. Penelitian ini menggunakan metodologi kualitatif dengan pendekatan studi kasus yang dilakukan di Pesantren Riyadlul 'ulum Wadda'wah Tasikmalaya. Pesantren yang dipilih memberdayakan para santri dengan memberikan kesempatan untuk mengelola berbagai usaha di lingkungan pesantren. Strategi keuangan ini tidak hanya melindungi stabilitas keuangan institusi, tetapi juga menumbuhkan rasa kepemilikan dan otonomi di kalangan santri. Penelitian ini memberikan kontribusi penting terhadap pemahaman pembangunan kemandirian dan semangat kewirausahaan di pesantren. Hasil menunjukkan bahwa melibatkan santri dalam manajemen usaha internal dapat meningkatkan keterampilan kewirausahaan dan tanggung jawab keuangan mereka. Dengan demikian, model manajemen inovatif ini bukan hanya melibatkan santri secara aktif dalam kegiatan ekonomi pesantren, tetapi juga menciptakan lingkungan yang merangsang perkembangan kemandirian dan semangat kewirausahaan di kalangan peserta didik. Temuan ini memiliki implikasi penting dalam meningkatkan relevansi pesantren sebagai lembaga pendidikan yang tidak hanya fokus pada aspek keagamaan tetapi juga mempersiapkan santri untuk menjadi individu mandiri dan berwawasan bisnis.
Analisis Proses Administrasi Pendidikan di Indonesia: Mengidentifikasi Distorsi dan Implikasinya
Authors: Pusvitasari Lina , Rahmatullah Ahmad , Hoer Uus Husni , Hasny Achmad Syihab , Al-Haedari Muhammad Rifki
Published: May 2024

Administrasi pendidikan di Indonesia berperan penting dalam menciptakan sistem pendidikan yang efisien dan efektif, menjamin pemanfaatan sumber daya dan kegiatan pendidikan secara optimal. Namun, realitas di lapangan menunjukkan bahwa administrasi pendidikan tidak luput dari distorsi, baik yang bersifat internal maupun eksternal, yang mungkin terjadi akibat manipulasi atau miskonsepsi, disengaja atau tidak. Distorsi ini dapat mengurangi efektivitas dan efisiensi proses pendidikan, merusak integritas sistem, dan menghambat pencapaian tujuan pendidikan yang berkualitas. Penelitian ini mengadopsi pendekatan kualitatif dengan menggunakan studi literatur dan wawancara untuk mengidentifikasi dan menganalisis distorsi yang terjadi dalam administrasi pendidikan di Indonesia. Studi literatur memberikan kerangka teoretis, sementara wawancara dengan berbagai stakeholder pendidikan memberikan insight empiris tentang manifestasi distorsi serta dampaknya terhadap sistem pendidikan. Temuan penelitian menunjukkan bahwa distorsi administrasi pendidikan mempengaruhi alokasi sumber daya, implementasi kebijakan, dan kualitas layanan pendidikan. Berbagai faktor yang berkontribusi pada distorsi ini termasuk kurangnya transparansi, akuntabilitas, dan standarisasi dalam proses administratif. Untuk mengatasi distorsi ini, diperlukan reformasi dalam sistem administrasi pendidikan yang mencakup peningkatan transparansi, akuntabilitas, dan pengadopsian praktik terbaik administrasi. Dengan mengidentifikasi dan mengatasi distorsi dalam administrasi pendidikan, diharapkan dapat menciptakan sistem pendidikan yang lebih adil, transparan, dan efektif, yang pada akhirnya akan meningkatkan kualitas pendidikan di Indonesia.
Pengembangan Modul Berbasis Life-Skill dalam Pembelajaran Matematika Materi Kecepatan pada Siswa Kelas V di SDN Mranggon Lawang 1 Probolinggo
Authors: Farihah Firna Nahwa , Sriwijayanti Ribut Prastiwi , Jannah Faridahtul , Wardana Ludfi Arya
Published: May 2024

Penelitian ini bertujuan untuk mengembangkan modul pada materi kecepatan untuk kelas V di SDN Mranggon Lawang Probolinggo dengan menggunakan pendekatan life skill. Modul ini dirancang secara sistematis dan mendukung pembelajaran mandiri. Jenis penelitian yang digunakan yaitu Research and Development (R&D). Instrumen yang digunakan pada penelitian ini yaitu, angket validasi ahli materi, dan ahli media serta angket respon guru dan siswa. Pembelajaran menggunakan Modul berbasis Life Skill materi kecepatan yang mana konsepnya sering dijumpai dalam kehidupan sehari-hari, sangat valid dan layak diterapkan pada kegiatan pembelajaran. Hasil validasi pada penelitian ini berdasarkan tingkat perolehan hasil kualifikasi valid/sangat valid yaitu ahli materi mendapat skor 90,6%, ahli media mendapatkan skor 87,5%. Dalam uji coba skala kecil angket kepraktisan guru mencapai  87,5% dan angket kemenarikan siswa mencapai 89%. Sedangkan untuk uji coba skala besar tingkat kepraktisan modul mencapai 94%, tingkat kemenarikan 91% .Uji coba lapangan dilakukan untuk mengukur kepraktisan Modul ini dalam meningkatkan pemahaman materi kecepatan dan kemampuan pemecahan masalah peserta didik. Berdasarkan hasil penilaian tersebut menunjukkan bahwa media yang dikembangkan oleh peneliti valid dan praktis dengan sedikit revisi, Modul yang dikembangkan oleh peneliti dapat dikatakan valid, praktis dan memudahkan siswa dalam proses belajar yang berlangsung
Peran Pendidikan Islam dalam Mendorong Perdamaian dan Toleransi di Masyarakat Multikultural
Authors: Ansyori Ahmad
Published: May 2024

Artikel ini mendalami peran strategis pendidikan Islam dalam menumbuhkan nilai perdamaian dan toleransi di tengah-tengah keragaman masyarakat multikultural. Mengadopsi pendekatan kualitatif, kajian ini menelusuri pengaruh kurikulum dan strategi pengajaran dalam pendidikan Islam terhadap pembinaan sikap toleran dan pengertian lintas budaya. Penelitian ini mengarahkan lensanya pada sejumlah institusi pendidikan Islam yang, menguraikan berbagai metode yang diterapkan oleh para pendidik untuk menyemai nilai perdamaian dan hidup berdampingan secara harmonis. Temuan penelitian menandai bahwa pendidikan Islam berperan vital dalam menanamkan keterampilan interkultural, memupuk empati, serta menggalang kolaborasi, yang semuanya esensial untuk menciptakan masyarakat yang damai dan toleran. Kajian ini menggarisbawahi perlunya suatu kurikulum yang inklusif dan merangkul, yang mendukung dialog dan pertukaran pemahaman antarkomunal, sebagai kunci untuk memperkuat efektivitas pendidikan Islam dalam memajukan toleransi dan koeksistensi dalam keragaman. Selanjutnya, analisis ini menegaskan bahwa pendidikan Islam tidak hanya berkontribusi pada pengembangan karakter individu tetapi juga memainkan peranan penting dalam memfasilitasi integrasi dan harmoni sosial. Dengan demikian, artikel ini menawarkan perspektif baru mengenai potensi pendidikan Islam sebagai pilar pendukung perdamaian dan toleransi, memperkaya wacana seputar pendidikan dalam konteks multikultural serta menawarkan arah baru untuk penelitian dan praktik pendidikan di masa depan.
Internalisasi Lima Nilai Karakter Budaya Sunda dalam Pendidikan Kewirausahaan
Authors: Ruswandi Yudi
Published: May 2024

Data tentang Tingkat Pengangguran Terbuka (TPT) di wilayah Kota Sukabumi menunjukkan bahwa secara berturut-turut dari tahun 2020-2022, yaitu: 11,15%, 7,07%, dan 7,39%. Angka tersebut merupakan angka yang masih cukup besar. Di mana sebagian besar di antaranya merupakan pengangguran intelektual yang berasal dari Sekolah Menengah Kejuruan (SMK) dan Perguruan Tinggi Vokasi. Tingginya tingkat pengangguran berakar pada kurangnya ketersediaan lapangan kerja dan kualitas lulusan lembaga pendidikan. Oleh karena itu, data tersebut merupakan alasan rasional dan pentingnya dilakukan penelitian. Berdasarkan pada akar permasalahan, dirumuskan dua masalah yaitu: 1) bagaimana proses penanaman lima nilai karakter budaya Sunda?; 2) bagaimana pelaksanaan pendidikan kewirausahaan yang diintegrasikan dengan internalisasi lima nilai karakter budaya Sunda?. Diharapkan penelitian ini dapat mendeskripsikan proses proses penanaman lima nilai karakter budaya Sunda melalui proses pendidikan kewirausahaan secara terintegrasi di Pondok Pesantren Dzikir Al-Fath Sukabumi. Pendekatan yang digunakan yaitu kualitatif naturalistik dengan metode kualitatif. Data digali dan dikumpulkan menggunakan teknik observasi, wawancara, dan studi dokumentasi, kemudian dianalisis dalam tiga tahap (mereduksi data, memvisualisasikan data dan menarik kesimpulan/verifikasi data). Sesuai dengan hasil penelitian, bahwa proses internalisasi lima nilai karakter yang berakar dari budaya Sunda di Pondok Pesantren Dzikir Al-Fath dilaksanakan secara terprogram dan terpadu dalam pendidikan kewirausahaan melalui jalur formal dan informal.
Pengaruh Literasi Keuangan Syariah Terhadap Preferensi Masyarakat Memilih Produk Bank Syariah Indonesia Cabang Garut
Authors: Hera Susanti Keuis
Published: May 2024

Dalam era keuangan yang semakin kompleks, literasi keuangan menjadi unsur kritis dalam membentuk preferensi masyarakat terhadap produk perbankan syariah. Penelitian ini mendalami dampak Literasi Keuangan terhadap Preferensi Masyarakat terhadap Produk Bank Syariah Indonesia di Cabang Garut. Fokus penelitian ditempatkan pada pemahaman masyarakat terkait dengan konsep dan manfaat produk perbankan syariah serta sejauh mana tingkat literasi keuangan mereka memengaruhi preferensi terhadap layanan tersebut. Penelitian ini menggunakan pendekatan kuantitatif dengan menyebarkan kuesioner kepada responden di Cabang Garut. Data yang terkumpul mencakup aspek literasi keuangan, pemahaman produk perbankan syariah, dan faktor-faktor yang mempengaruhi preferensi. Analisis statistik, terutama regresi, digunakan untuk mengukur sejauh mana literasi keuangan berkontribusi pada pembentukan preferensi masyarakat terhadap produk perbankan syariah. Melalui pendekatan ini, penelitian ini bertujuan memberikan wawasan mendalam tentang hubungan kompleks antara literasi keuangan dan preferensi masyarakat. Hasil yang diharapkan dapat menjadi landasan bagi Bank Syariah Indonesia untuk merancang program literasi keuangan yang sesuai dengan kebutuhan masyarakat Garut. Pemahaman mendalam tentang preferensi masyarakat ini tidak hanya meningkatkan partisipasi mereka dalam produk perbankan syariah tetapi juga memberikan arah bagi inovasi produk yang lebih sesuai dengan kebutuhan dan ekspektasi lokal. Penelitian ini memiliki implikasi penting dalam konteks pemberdayaan ekonomi masyarakat, di mana literasi keuangan dapat menjadi alat efektif dalam mengakselerasi pertumbuhan perbankan syariah di tingkat lokal. Sehingga, dapat memberikan kontribusi positif terhadap inklusivitas keuangan dan perkembangan ekonomi di Garut dan sekitarnya.
Perbankan Syariah dalam Ekonomi Global: Analisis Prinsip, Implementasi, dan Dampaknya
Authors: Susanti Illa
Published: May 2024

Penelitian ini menyelidiki kontribusi perbankan syariah dalam konteks ekonomi global. Fokus utama adalah pada prinsip-prinsip dasar perbankan syariah, implementasinya di berbagai negara, dan dampak yang ditimbulkannya terhadap ekonomi global. Perbankan syariah, yang beroperasi sesuai dengan hukum syariah Islam, menawarkan alternatif bagi sistem perbankan konvensional. Prinsip utamanya adalah larangan bunga (riba), praktik bagi hasil, dan investasi pada transaksi yang etis dan halal. Penelitian ini menggunakan pendekatan kualitatif dengan analisis data sekunder dari berbagai laporan keuangan dan studi akademis. Implementasi perbankan syariah telah meluas ke berbagai negara, tidak terbatas pada negara-negara mayoritas Muslim. Hasil penelitian menunjukkan bahwa perbankan syariah memberikan dampak signifikan terhadap inklusi keuangan, khususnya di negara berkembang. Lebih lanjut, praktik bagi hasil telah terbukti mengurangi risiko dan meningkatkan kestabilan dalam sistem keuangan. Penelitian ini juga mengeksplorasi tantangan yang dihadapi oleh perbankan syariah, termasuk masalah standarisasi dan persepsi publik. Secara keseluruhan, hasil penelitian menunjukkan bahwa perbankan syariah memiliki potensi untuk berkontribusi secara positif terhadap ekonomi global, terutama dalam konteks stabilitas keuangan dan inklusi sosial. Kedepannya, perbankan syariah dapat menjadi pemain kunci dalam perekonomian global, seiring dengan peningkatan kesadaran dan pemahaman terhadap prinsip syariah.