bluuebunny/crossref_metadata_2025 huggingface dataset:
Cognitive function and metabolic features in male Sprague-Dawley rats receiving high-fat and low-calorie diets
Authors: Shestakova Ekaterina A. , Stavrovskaya Alla V. , Gushchina Anastasiya S. , Yamshikova Nina G. , Olshansky Artyom S.
Published: March 2019

Background: Obesity is a risk factor for cognitive disorders. However, it is still unknown whether low-calorie diet will improve cognitive function in obese patients.
Aim: To evaluate cognitive function and metabolic features in male Sprague-Dawley rats receiving high-fat and low-calorie diets.
Materials and methods: The work was carried out on Sprague Dawley male rats (n = 32), which were divided into 2 groups with 16 animals in each group: Control (normal / low-calorie diet) and Obesity (high-fat diet). In 90 days the rats of the Control group were transferred to a low-calorie diet, the rats of the Obesity group continued to receive high-fat diet. To assess motor activity and cognitive functions at the end of the study (180 days), following behavioral tests were conducted: "open field", "tapering beam", "elevated plus-maze" (EPM) and "passive avoidance reaction". During the study glucose tolerance test were performed: at baseline (GTT 1) and in 30 days (GTT 2).
Results: Obesity group rats gained weight significantly faster than the control animals (547.69 11.32 g against 442.8 19.8 g at study end, p = 0.0001). GTT 2 showed normal carbohydrate metabolism in control group, postprandial hyperglycemia in obesity group. Testing in the open field showed that the rats of the obesity group moved more actively across the installation area than the control ones: the total distance covered was 9.352 0.932 m against 6.781 0.951 m, p = 0.046.
The results of a tapering beam test showed that the number of hind limb extrusions in obese rats significantly exceeded this parameter in control group (33.7 3 vs. 15.7 2.7, p = 0.0001), test time in both groups did not differ.
When testing in EPM, there was no significant difference in any of the key test parameters between the groups. However, the number of looking out from the closed arms in animals of the obesity group was significantly higher than in the control group (4.19 0.6 vs. 2.30 0.58, p = 0.044). When testing the reproduction of conditional reactions of passive avoidance it was shown that after day 1 of the pain stimulation application the latent period of transition to the dark compartment in the obesity group was significantly higher than that of the control group (180.0 0.0 vs. 128 86 21.45, p = 0.008). This indicates a better preservation of the memorial trail compared to the "control" rats. By the end of the study 30% of animals in the control group died.
Conclusions: Rats on high-fat diet were more active, less anxious and showed better results in training tests comparing to animals on low-calorie diet. Adherence to low-calorie diet may be harmful for cognitive functions.
Hormonal regulation of menstrual function in patients of reproductive age with acromegaly
Authors: Vorotnikova Svetlana Yu. , Dzeranova Larisa K. , Stanoevich Irina V. , Pigarova Ekaterina A. , Andreeva Elena N. , Nikankina Larisa V. , Masenko Valery P.
Published: March 2019

Background: The frequency of menstrual disorders in patients with acromegaly is 4084% and are caused by three main reasons the development of normal or hypogonadotropic hypogonadism due to hyperprolactinemia or a mass effect of the tumor and direct effects of GH and IGF-1 on the reproductive system. Nevertheless the exact mechanisms of reproductive dysfunction are not clear now. Hypothalamic structures play significant role in the regulation of hypothalamic-pituitary-ovary axis, so its important to study key neuropeptides and evaluate their effects to the pathogenesis of ovarian dysfunction during excessive secretion of growth hormone.
Aim: The aim of the work is to study the hormonal regulation of menstrual function in patients of reproductive age with acromegaly in the active stage of the disease.
Material and methods: The study included patients with a confirmed diagnosis of acromegaly and healthy women, comparable in age and BMI. Blood serum samples were taken in the morning (89 hours) on an empty stomach for 35 days of the menstrual cycle or on any day with amenorrhea and frozen at -70C. The hormonal study was carried out by an enzyme immunoassay, in the case of a kisspeptin, with the preliminary extraction of serum samples.
Results: The study included 31 patients with acromegaly and 15 healthy women. Between groups there was a statistically significant decrease in levels of LH (p = 0.001), FSH (p = 0.09), inhibin B (p = 0.003), and kisspeptin (p = 0.00005). The frequency of hyperprolactinemia in the cohort of patients was 51.6%. During the correlation analysis, a negative dependence of kisspeptin on the levels of GH and IGF-1 was detected (r = -0.54, p = 0.002 and r = -0.63, p = 0.0002).
Conclusions: The severity of the central depression of regulation of menstrual function in patients with acromegaly may be due to the degree of disease activity.
Evaluation of relationship between obesity and asthma severity
Authors: Rabieepour Masome , Seyed Mokhtari Seyed Arman , Mamizadeh Hamed
Published: March 2019

Background: The prevalence of both obesity and asthma has risen in recent years. We sought to investigate whether obesity may be related to asthma.
Materials and methods: In this analytical study, 177 patients with asthma were enrolled. Obesity was defined as a body mass index (BMI) greater than 30. Asthma severity was defined by using the National Heart Lung and Blood Institute 1997 guidelines.
Results: Of the 177 patients, there were 80 males and 97 females. 38.4 percent of the sample was obese. There is no significant relationship between BMI and asthma severity (P=0.76) but as established by Pearsons correlation coefficient a positive and significant correlation is present between BMI and FEV1/FVC values (r=0.32 P=0.0001). Females with asthma were significantly more overweight than males (p = 0.001).
Conclusions: In our study, there was a significant correlation between body mass index and sex of patients with asthma. Women had the highest percentages of asthma compared to men, and had a higher body mass index than men.
Advantages and disadvantages of different methods for diagnosis of visceral obesity
Authors: Brel Natalia K. , Kokov Aleksandr N. , Gruzdeva Olga V.
Published: March 2019

This analytical review is devoted to the study of visceral obesity as a risk factor for the development and progression of cardiovascular diseases. The presented review discusses the evolution of methods for diagnosis of visceral obesity, their advantages and limitation for various ectopic fat depots.
Metabolic aspects of the relationship of asthma and obesity
Authors: Kytikova Oxana Y. , Antonyuk Marina V. , Gvozdenko Tatyana A. , Novgorodtseva Tatyana Р.
Published: March 2019

Asthma and obesity are serious medical and social world problems, and their combined course is characterized by a decrease in the quality of life, an increase in the frequency and duration of hospitalization. The present review summarizes the current views on the mechanisms of formation of asthma phenotype combined with obesity, role of leptin and adiponectin imbalance in the development of systemic inflammation in obesity in the pathophysiology of asthma, its interrelations with metabolic syndrome. We present data that shows that syndrome is closely related not only to the debut of asthma, but also to a decrease in its control. Along with obesity, the role of other components of metabolic syndrome, in particular insulin resistance, as a predictor of asthma development is considered. Insulin resistance may be the most likely factor in the relationship between asthma and obesity, independent of other components of the metabolic syndrome. Insulin resistance associated with obesity can lead to disruption of nitric oxide synthesis. We reveal common mechanism of metabolic disorders of nitric oxide and arginine in metabolic syndrome and asthma and show that insulin resistance treatment can be therapeutically useful in patients with asthma in combination with obesity.
Predictors of effectiveness of glucagon-like peptide-1 receptor agonist therapy in patients with type 2 diabetes and obesity
Authors: Tikhonenko Ekaterina V. , Babenko Alina Y. , Shlyakhto Evgeny V.
Published: March 2019

Background: Type 2 diabetes mellitus (DM2), which mainly develops from visceral obesity, is a socially significant disease. Reduction of losses from DM2 is a priority in modern medicine development. Glucagon-like peptide-1 receptor agonists (aGLP-1) present one of few groups of antidiabetic drugs that allows to reduce not only glycemia, but also weight in DM2. Taking into account predictors of response to the therapy will allow to reach trearment targets with the highest probability, maintaining a safety of treatment, to optimize recommendations for administration of aGPP-1 as much as possible.
Aims: To assess dynamics of metabolic parameters, to identify predictors of reduction in blood glucose, body weight and other metabolic parameters on aGLP-1 therapy in patients with DM2 with body mass index (BMI) 35 kg/m2.
Materials and methods: The study involved 33 patients (10 men, 23 women), who had been treated with aGLP-1, the observation period for 24 weeks was planned. 3 patients terminated the participation before the appointed time (1 due to pancreatitis development 2 due to the lack of financial opportunity to purchase the drug). So, 30 patients (10 men, 20 women) were included in the final analysis. Examination consisted of the survey, physical examination with measurement of anthropometric, clinical parameters, filling questionnaires. Data were evaluated at baseline and after 24 weeks of treatment.
Results: The study found that patients who achieved weight loss 5% initially had higher BMI (p = 0.028), lower GLP-1 (p = 0.036), had lower level of ghrelin after standard breakfast test (p = 0.022). There was trend (p = 0.071) to greater decrease in BMI in patients with restrictive type of eating behavior compared to patients who had a mixed type. More pronounced decrease in glycemia was noted in patients who had higher fasting plasma glucose level at inclusion (p = 0.001). Dynamics of HbA1c was better in patients with initially higher GLP-1 (p = 0.016) and higher levels of glycemia (p = 0.001). Also, we revealed the statistically significant decrease in triglycerides level, blood pressure by end of the treatment period.
Conclusions: Results indicate the different predictors for reduction in weight, glycemia and blood pressure on aGLP-1 therapy. In addition to the metabolic parameters, level of orexigenic and anorexigenic hormones and psycho-social characteristics of patients help to estimate an expected effect of aGLP-1 therapy. When being identifying, the predictors of weight loss and the predictors of carbohydrate metabolism compensation should be studied separately. Identification of response predictors is necessary to optimize indications for this group of drugs administration in DM2.
The spermatogenesis and antioxidative activity of an ejaculate in young men with post pubertal visceral obesity and normal andrological anamnesis
Authors: Rozhivanov Roman V. , Kurbatov Dmitriy G.
Published: March 2019

Background: Taking into account a common development of a visceral obesity at men, research of its influence on a spermatogenesis and antioxidative activity of an ejaculate is actual.
Aims: Assessments of spermatogenesis and antioxidative activity of ejaculate in young men with post pubertal visceral obesity and normal andrological anamnesis in comparing with healthy men.
Materials and methods: 80 men with post pubertal and nutritional visceral obesity in the age of until 30 years and 30 healthy men have been included in cross-section research. The assessments of waist circumference, levels of gonadotropins and total testosteron, antioxidant activity of an ejaculate, its electronic-microscopic examination was carried spent. Statistically significant counted differences between groups at p 0.05.
Results: In young men with post pubertal visceral obesity and normal andrological anamnesis the spermatogenesis was significantly worse in comparing with healthy men. These differences were were significant for waist circumference more more then 98 cm. Antioxidative activity of ejaculate in men with visceral obesity also was significantly lower in comparing with healthy men. The maximal expressiveness of sperm pathogenetic disorders was in men with waist circumference more then 102 cm.
Conclusions: In young men with post pubertal visceral obesity and normal andrological anamnesis the spermatogenesis is worse compared to healthy men. If the waist circumference less than 102 cm, the spermatogenesis is normal in most cases, but antioxidant activity of an ejaculate is pathological and mediated through oxidative stress.
Тhe prevalence of metabolically healthy obesity: data from the epidemiological survey in of Novosibirsk
Authors: Mustafina Svetlana V. , Shcherbakova Liliya V. , Kozupeeva Darya A. , Malyutina Sofiya K. , Ragino Yulia I. , Rymar Oksana D.
Published: March 2019

Background: Obesity is associated with numerous metabolic complications, such as type 2 diabetes mellitus (DM2), dyslipidemia, arterial hypertension (AH), cardiovascular diseases and some forms of cancer. Nevertheless, the literature describes a group of obese individuals who are more resistant to the development of metabolic disorders. At present, this phenomenon is known as "Metabolically healthy obesity", "metabolically healthy obesity" (MZO). Despite the presence of excess weight or obesity, a favorable metabolic profile can be observed in this cohort of patients, characterized by preserved insulin sensitivity, absence of arterial hypertension, normal lipid, hormonal profile, absence of inflammation and unchanged hepatic transaminases.
Aims: To study the prevalence of metabolically healthy obesity (MHO) and its characteristics in men and women at the age of 4569 years in Novosibirsk.
Materials and methods: To study covered 3197 persons from the base of the international project HAPPIE. They had a body mass index (BMI 30 kg/m). Metabolically healthy obesity was determined as obesity (BMI 30 kg/m, with 2 and fewer components of metabolic syndrome (MS) by criteria NCEP ATP III, 2001. Statistical analisys SPSS-13.
Results: The prevalence of metabolic healthy obesity (MHO) was 42% (38% for men and 43% for women). The examined people with MHO have reliably more favorable average level of TG, HDL-cholesterol, indicators of blood glucose, systolic arterial pressure and diastolic arterial pressure and less waist circumference. In the groups withMHO and MS abdominal obesity is common in men at 95 and 71%, in women at 99 and 90%; hyperTG in men at 74 and 9%, in women at 72 and 5,5%; lower level HDL-cholesterol in 16 and 1% for men, and in 44,5% and 3% for women; AP in 96 and 77% and 94 and 71% in men and women respectively, the frequency fasting of hyperglycaemia 77 and 21% in men and 60 and 5% in women was markedly different. According to the data obtained by us, the frequency in the sample is high and amounted to 42%. In the subgroup the most commonly found is the MHO phenotype 53%, than in the men -38%, р 0,001
Conclusions: According to our data, the frequency of metabolic healthy obesity in the sample is high and amounted to 42%. In the female subgroup, a metabolically healthy phenotype is more common 43% than in the male 38%, p 0.001. Metabolically healthy obese individuals are characterized by a significantly lower incidence of fasting hyperglycaemia and dyslipidemia.
Exhibiting Moments: Qualla Arts and Crafts Mutual at the Mathers Museum of World Cultures
Authors: Rogers Emily Buhrow
Published: March 2019

In 1973, Indiana University’s Mathers Museum of World Cultures purchased a selection of works from the Eastern Band of Cherokee Indians’ Qualla Arts and Crafts Mutual, one of the oldest Native American-owned art and craft cooperatives in the United States. In this paper, I discuss, from my perspective as co-curator, the development of the museum’s 2015 exhibition of that collection, Cherokee Craft, 1973. Through this project, the curatorial team sought to creatively evoke the Qualla cooperative at the dynamic historical moment these works represented, while also contending with significant resource limitations. What resulted was an exhibit organized around the concept of a moment in time. This alternative presentation strategy gave us an opportunity to explore a variety of important topics and ongoing processes specific to the institution in the early 1970s. In this paper, I discuss how this approach allowed us to present a plurality of voices, while also showcasing many of the cooperative’s most renowned makers. I also position Cherokee Craft, 1973 as an exhibit curated by graduate students for a university audience: it was a site of innovation and representational experimentation for its creators, unique to its institutional type and its own particular moment in time.
X-ray crystal structure of N'-[(1E)-1-(2,4-dihydroxyphenyl)-ethylidene]pyridine-4-carbohydrazide
Authors: Jayaprakash Venkatesan , Timiri Ajay Kumar , Vijayan Viswanathan , Sinha Barij Nayan , Devadasan Velmurugan
Published: March 2019

Schiffâ€™s base of isonicotinyl hydrazide with 2â€™,4â€™-dihydroxy acetophenone (INH-RA) has been designed and synthesized as a part of library enumeration targeting the NS2B-NS3 protease of Dengue virus. Slow evaporation from methanol results in the formation of monoclinic crystalsÂ C2/c space group with eight molecules in the unit cell (a=20.0165(3) Ã…, b=7.7594(10) Ã…, c=19.4809(3) Ã…, Î±=90 Â°, Î²=111.368(1) Â°, Î³=90 Â° and Z=8).Three dimensional X-ray crystallographic structure of the compound has been determined and refined usingÂ SHELXS-97 and SHELXL-2014, respectively to a final R-value of 4.64%
Branched Coverings and Minimal Free Resolution for Infinite-Dimensional Complex Spaces
Authors: Ballico E.
Published: March 2019

We consider the vanishing problem for higher cohomology groups on certain infinite-dimensional complex spaces: good branched coverings of suitable projective spaces and subvarieties with a finite free resolution in a projective space P(V ) (e.g. complete intersections or cones over finitedimensional projective spaces). In the former case we obtain the vanishing result for H
1. In the latter case the corresponding results are only conditional for sheaf cohomology because we do not have the corresponding vanishing theorem for P(V ).
Bi-Hamiltonian Structure as a Shadow of Non-Noether Symmetry
Authors: Chavchanidze G.
Published: March 2019

The correspondence between non-Noether symmetries and bi-Hamiltonian structures is discussed. We show that in regular Hamiltonian systems the presence of the global bi-Hamiltonian structure is caused by the symmetry of the space of solution. As an example, the well-known bi-Hamiltonian realization of the Korteweg–de Vries equation is discussed.
Inchoatives in causative clothing
Authors: Kastner Itamar
Published: March 2019

The “causative” templateheXYiZin Hebrew is the morphological form of verbs which are usually transitive. I discuss cases in which specific roots give rise to the labile alternation, otherwise unattested in the language. A straightforward analysis is suggested for the majority of cases, based on causativeVoice[+D]$\text{Voice}_{\text{[+D]}}$. This analysis is then extended to account for the labile exceptions, which inform how the idiosyncratic meaning of roots influences syntactic computation.
Transcriptome analyses of ovarian stroma: tunica albuginea, interstitium and theca interna
Authors: Hummitzsch Katja , Hatzirodos Nicholas , Macpherson Anne M , Schwartz Jeff , Rodgers Raymond J , Irving-Rodgers Helen F
Published: March 2019

The ovary has specialised stromal compartments, including the tunica albuginea, interstitial stroma and theca interna, which develops concurrently with the follicular antrum. To characterise the molecular determinants of these compartments, stroma adjacent to preantral follicles (pre-theca), interstitium and tunica albuginea were laser microdissected (n = 4 per group) and theca interna was dissected from bovine antral follicles (n = 6). RNA microarray analysis showed minimal differences between interstitial stroma and pre-theca, and these were combined for some analyses and referred to as stroma. Genes significantly upregulated in theca interna compared to stroma includedINSL3,LHCGR,HSD3B1,CYP17A1,ALDH1A1,OGN,POSTNandASPN. Quantitative RT-PCR showed significantly greater expression ofOGNandLGALS1in interstitial stroma and theca interna versus tunica and greater expression ofACDin tunica compared to theca interna.PLNwas significantly higher in interstitial stroma compared to tunica and theca. Ingenuity pathway, network and upstream regulator analyses were undertaken. Cell survival was also upregulated in theca interna. The tunica albuginea was associated with GPCR and cAMP signalling, suggesting tunica contractility. It was also associated with TGF-β signalling and increased fibrous matrix. Western immunoblotting was positive for OGN, LGALS1, ALDH1A1, ACD and PLN with PLN and OGN highly expressed in tunica and interstitial stroma (eachn = 6), but not in theca interna from antral follicles (n = 24). Immunohistochemistry localised LGALS1 and POSTN to extracellular matrix and PLN to smooth muscle cells. These results have identified novel differences between the ovarian stromal compartments.
Çürük belirleme yöntemlerine güncel yaklaşımlar
Authors: BAYRAK Gökçen Deniz , SELVİ-KUVVETLİ Senem
Published: March 2019

Bir çürük lezyonuna erken aşamada tanı
konulması, diş dokusunun olabildiğince korunmasına katkıda bulunabilecek en uygun
tedavi planının oluşturulmasına olanak sağlar. Diş çürüğünün belirlenmesinde ve
kaydedilmesinde kullanılan sistemler arasında tutarsızlıkların olması,
epidemiyolojik ve klinik çalışmalarda elde edilen sonuçların karşılaştırılabilmesini
zorlaştırmaktadır. Bu nedenle; diş hekimliği eğitiminde, klinik uygulamalarda
ve araştırmalarda kullanılabilecek, çürüğün tüm aşamaları ile
değerlendirilmesini sağlamak amacı ile bir klinik çürük skorlama sistemi olan Uluslararası
Çürük Belirleme ve Değerlendirme Sistemi
(ICDAS)
geliştirilmiştir. Yapılan
toplantılar sonucunda ICDAS kriterleri tekrar gözden geçirilmiş ve bazı
değişiklikler yapılarak ICDAS II kriterleri ortaya konulmuştur. ICDAS II baz alınarak çürüğün doğru şekilde tedavi edilebilmesi ve hastanın
çürük risk grubunun belirlenerek ağız hijyeninin en iyi şekilde sürdürülebilmesi
amacıyla da Uluslararası
Çürük Sınıflaması ve Yönetim Sistemi (ICCMS) geliştirilmiştir. Günümüzde bu sistemler yaygın bir şekilde kullanılmaya
başlanmıştır ve bu sayede diş hekimliğinde girişimsel uygulamaların azalacağı
düşünülmektedir. 

Anahtar
kelimeler: diş çürükleri, erken
teşhis, ICDAS, ICCMS
Dev Tükürük Bezi Taşlarının Cerrahi Eksizyonu: İki Vaka Raporu
Authors: DELİLBAŞI Ertan Ali , MAMMADOVA Ulviyya , SİVRİ Damla , GÖKSU Vahit Can , ÖZTÜRK Kübra
Published: March 2019

Özet

Sialolithiazis,
“sialolit” olarak tanımlanan tükürük bezi taşlarının gelişimi ile oluşan bir
rahatsızlıktır. Sialolitiazis  %80
oranında submandibular tükürük bezinin içinde veya duktusunda görülmektedir.
Tükürük bezi hastalıklarının tanısında farklı görüntüleme teknikleri
kullanılabilir.  Bu makalede iki farklı
hastanın submandibular tükürük bezin duktusunda teşhis edilen sialolitlerin
cerrahi eksizyonu rapor edilmektedir.
Konik Işınlı Bilgisayarlı Tomografide Maksiller ve Mandibular Süpernümere Dişlerin Lokalizasyonları, Karakteristikleri ve Komplikasyonları
Authors: MENZİLETOĞLU Dilek , ERDUR Emire Aybüke , BAŞTÜRK Funda
Published: March 2019

Amaç: Süpernümere
dişler, normal diş sayısından fazla olan dişler olarak tanımlanmaktadır. Hem
süt hemde daimi dentisyonda süpernümere dişlere rastlanılmaktadır.
Etiyolojileri tam olarak bilinmemektedir. Genelde gömülüdür ve radyograflarda
tesadüfen görülürler. Bu sunum, süpernümere dişlerin panoramik radyograf ve
konik ışınlı bilgisayarlı tomografi (KBIT) kullanılarak lokalizasyonunu
değerlendirmek ve tedavi yaklaşımlarını sunmaktadır. Gereç ve Yöntemler:Bu retrospektif çalışmada 6273 hastanın
radyografik verileri Necmettin Erbakan Üniversitesi, Diş Hekimliği Fakültesi
Ağız, Diş Çene Cerrahisi ve Ortodonti bölümlerinde incelendi. Süpernümere diş
sayısı, dişin anatomik lokalizasyonu, erüpsiyon durumu panoramik radyografta ve
KBIT’ta incelendi. Bulgular:6273
hastanın 64’ünde (40 erkek,  24 kadın) 66
süpernümere diş teşhis edildi. Hastaların yaş aralığı 9-65 yıl ve yaş ortalaması 22.47 yıldı. 2 hastada  (mandibula premolar ve molar bölge) çift
taraflı süpernümere diş vardı. 43 süpernümere diş gömülüydü. Bu dişlerin 33’ü
konik formda, 10’u da odontoma şeklinde ve 23’ü ise diş şeklindeydi.
Süpernümere dişlerin hepsi çekildi. 44 süpernümere diş ortodontik tedavi için
çekildi.  2 hastada maksilla premolar
bölgede görülen süpernümere diş ile birlikte görülen kist enükle edildi,
patolojik teşhis ile dentigeröz kist tanısı konuldu. 14 süpernümere diş
profilaktik olarak çekildi.  6 hastada
anterior bölgede dolgu ve protez yaptıracağı için dişleri çekildi.Sonuçlar:Süpernümere
dişlerin büyük çoğunluğu gömülü olduğundan rutin klinik muayeneler sırasında
teşhis edilememekte ancak komplikasyona neden olduklarında veya radyografik
incelemeler sırasında saptanabilmektedir. KBIT, süpernümere dişlerin şekli ve
lokalizasyonu ile ilgili 3 boyutlu görüntü sağlamaktadır.  Ortodontik tedavi görecek hastalarda
süpernümere dişler daimi dişlerin hareketine engel olmaktadır. Erken tanı ve tedavi ilişkili komplikasyonların
önlenmesi açısından önemlidir.Anahtar Kelimeler:Süpernümere
dişler, konik ışınlı bilgisayarlı tomografi, ortodontik tedavi
SEGMENTAL KANİN RETRAKSİYONUNDA PREFABRİKE LADANYİ SPRİNG VE REVERSE CLOSİNG LOOP’UN KARŞILAŞTIRILMASI
Authors: KÖK Hatice , GÖYENÇ Yaşar Bedii
Published: March 2019

Çekimli
vakalarda maksiller kaninlerin retraksiyonu ortodontik tedavinin esas
safhalarından birisidir. Retraksiyon sonrasında kaninlerin doğru pozisyonda
olmaları fonksiyon, estetik ve stabilite için önemlidir. Edgewise tekniğinde
kaninler iki yolla retrakte edilmektedir. Birinci yöntem sürtünmeli yöntem
olarak da adlandırılır, devamlı ark teli üzerinde kaninlere kuvvet uygulanması
ile ark üzerinde gerçekleştirilen yöntemdir. İkinci yöntemde ise bölümlü arklar
ve springler yardımıyla sürtünmesiz bir şekilde retraksiyon sağlanmaktadır.
Sürtünmesiz sistem ile boşluk kapama yöntemi; bukkal segmental looplar veya
retraksiyon springlerinin kullanımı yardımıyla bilinen M/F oranları oluşturmaya
dayanmaktadır. Ayrıca optimum büyüklükte, nisbeten sabit ve önceden
belirlenebilen kuvvetlerin salınımı öngörülmektedir. Çalışmanın amacı
prefabrike Ladanyi springin, elde bükümü yapılmış olan reverse closing loop ile
kıyaslanması, ankraj dişler ve kaninler üzerinde meydana gelen değişimleri
değerlendirmektir.

Çalışmaya
yaşları 12,51-16,94 yıl arasında ortalama 15,82 yıl olan 9 kız, 3 erkek toplam
12 hasta dahil edilmiştir. Prefabrike Ladanyi spring hastaların sağ
taraflarına, reverse closing loop ise sol tarafına yerleştirilmiştir. Seanslar
4 haftada bir yapılmıştır. Her hastadan referans telleri yerleştirilerek
sefalometrik radyograflar alınmıştır. Periyotlara göre sağ ve sol fark
karşılaştırılmasında 2-bağımsız örnek testi Mann-Whitney U analizi, periyotlar
arası  kıyaslama için Friedman testi
kullanılmıştır.

Çalışmamızda
kanin retraksiyonu Ladanyi tarafında 5,15±0,75 ay devam etmiştir. Kanin
retraksiyonu sonrasında molar dişlerde ankraj kaybı, sellanasion düzlemine göre
kaninlerde intruzyon-molarlarda ekstruzyon ve overjette spontan düzelme
gözlenmiştir. Ayrıca kaninlerde distale devrilme, molarlarda meziale devrilme
gözlenmiştir.
Enfoques de género e interculturalidad en salud: una metodología para cubrir la necesidad de su apropiación sostenible en el Perú
Authors: Vincx Laura , Geysels Luc
Published: March 2019

En el Perú existen grandes brechas de género e interculturalidad, particularmente en el sector salud. Estas brechas dan lugar a discriminación, muertes maternas e infantiles, maltrato y deshumanización de la atención de salud. Para mejorar la calidad sanitaria, el Programa SISTEC usó como metodología dictar talleres en género e interculturalidad; así, organizó 44 en 5 regiones y capacitó a 837 profesionales en salud. Sistematizando la experiencia, varios factores para mejorar los resultados resaltaron, como la selección de participantes, la adecuación cultural y la metodología utilizada. Los talleres impulsaron cambios socio-culturales en el ámbito laboral y personal, pero su sostenibilidad depende de las estrategias de institucionalización. Se concluye que los talleres pueden ser una metodología útil para impulsar la apropiación sostenible de los enfoques de género e interculturalidad, siempre y cuando forman parte de una estrategia holística y adecuadamente planificada donde los talleres sirvan como el punto de partidapara el cambio.
Prevalencia y factores asociados a conducta suicida en estudiantes de la Universidad Nacional Mayor de San Marcos, Lima-Perú
Authors: Perales Alberto , Sánchez Elard , Barahona Lorenzo , Oliveros Miguel , Bravo Eric , Aguilar William , Ocampo Juan Carlos , Pinto Miguel , Orellana Ivón , Padilla Alberto
Published: March 2019

Introducción. La Organización Mundial de la Salud ha señalado el incremento de riesgo suicida en personas de 15 a 44 años, grupo etario en el que se ubican los estudiantes universitarios. Objetivo. Determinar prevalencias de conducta suicida y variables asociadas en estudiantes de pregrado de la Universidad Nacional Mayor de San Marcos (UNMSM), Lima-Perú. Métodos. Estudio analítico, transversal. La población objetivo fue de 24 118 estudiantes matriculados en 2015. Se aplicaron los instrumentos de conducta suicida de la Encuesta Nacional de Salud Mental en el Perú 2002 y 2012, las escalas de ansiedad y depresión de Zung y el cuestionario CAGE para problemas de alcohol, a una muestra de 1819 estudiantes obtenida mediante muestreo bietápico. Se estimaron prevalencias y se empleó regresión logística para determinar factores asociados. Resultados. Las prevalencias de vida, último año, últimos seis meses y último mes de los componentes de la conducta suicida fueron: deseos de morir (35%; 13,9%; 11% y 5,6%); ideación suicida (22,4%; 8,2%; 6% y 3,3%); plan suicida (17,7%; 4,4%; 3,5% y 1,6%); e intento suicida (11,1%; 3,7%; 2,8% y 1,4%). Los factores de riesgo en términos de odds ratio (OR) ajustados y sus IC 95% fueron: condición de mujer 1,48 (IC 95%: 1,03-2,12), depresión 2,46 (IC 95%: 1,49-4,06), angustia 2,5 (IC 95%: 1,38-4,6), y vivir en hogar no nuclear 2,51 (IC 95%: 1,70-3,72). De los estudiantes que intentaron suicidarse sólo 16% buscó ayuda profesional y 21% pensó repetir el intento. Conclusiones. Los estudiantes de la UNMSM tienen mayor riesgo de conducta suicida que los de la población en general, tanto por razones científicas como por responsabilidad moral se recomienda implementar estrategias de intervención para revertir esta tendencia y proteger a este valioso recurso humano.
Reconstrucción primaria con implantes personalizados después de resección de gran tumoración craneofacial
Authors: Nuñez José , Saenz Gustavo , Chávez-Asmat Roberto , Tejada-LLacsa Paul Jesús
Published: March 2019

Reportamos la reconstrucción inmediata con implantes personalizados en la región craneofacial en una paciente mujer de 22 años con tumoración craneofacial de 12x15 cm en la región fronto orbito cigomático izquierdo que correspondió a fibroma oscificante. Se realizó la reconstrucción con un implante hecho a medida basado en imágenes tomográficas. El implante de polieteretercetona (PEEK) fue seleccionado para reemplazar la pérdida ósea y para restaurar la anatomía facial. No hubo necesidad de ajuste transquirúrgico del implante; ni se presentaron reacciones de rechazo, infección o exposición del implante en el periodo posoperatorio. Aunque el hueso autólogo es preferido para implantes, resulta difícil adecuarlos en situaciones de un compromiso extenso como en el caso presentado; por ello los implantes de PEEK son actualmente una opción en términos de biocompatibilidad, resistencia, duración, conductividad térmica y traslucencia radiográfica.
El sistema nacional de salud del Perú. Entrevista al Dr. David Tejada de Rivero
Authors: Cañizares Fuentes Wilson Ricardo
Published: March 2019

A propósito de mi tesis doctoral: “Evolución del sistema de salud de Perú, 2005-2014. Buenas prácticas de gestión”, de la Facultad de Medicina, Universidad Nacional Mayor de San Marcos, del año 2017, realicé una entrevista a profundidad al Dr. David Tejada de Rivero en junio de 2015. En ocasión anterior ya le había realizado una entrevista sobre la Atención Primaria de la Salud y su rol en la declaración de Alma Ata, disponible en YouTube. La tesis buscaba entender y explicar los avances y desafíos del sistema nacional de salud del Perú, las buenas prácticas y los factores que influyeron en su implementación. Para alcanzar ese propósito, en base a la metodología de investigación cualitativa se consultaron las opiniones, discurso y reflexiones de altos directivos del Ministerio de Salud, expertos de salud pública, académicos y representantes de la sociedad civil peruana, entre los que estaba incluido el Dr. David Tejada. La entrevista fue realizada en su departamento en Miraflores, Lima, grabada y transcrita para realizar su posterior análisis. La entrevista fue previamente consultada y concertada con el entrevistado, así como todas las entrevistas que se hicieron a propósito del estudio. Por considerar de interés académico e histórico se consideró la importancia de publicar la entrevista completa del Dr. David Tejada de Rivero como homenaje y reconocimiento a sus importantes contribuciones a la salud publica peruana y mundial.
Actitud de odontólogos acerca de la atención de pacientes con necesidades especiales
Authors: Cançado Figueiredo Márcia , Nicoli Haas Andressa , Scariot Débora , Luchsinger Lima Geisa , Concha Melgar Ximena
Published: March 2019

Objetivo: Evaluar la actitud de los cirujanos dentistas acerca de la atención odontológica de pacientes con necesidades especiales (PNE). Métodos:Estudio transversal que utilizó el método cuantitativo a través de un cuestionario que fue contestado por 60 cirujanos dentistas (CDs) asistentes a una Jornada Odontológica del estado de Río Grande do Sul, Brasil.Resultados: El 73% de los CDs no atienden este tipo de pacientes, de los cuales: 62,1% por no saber atenderlos; 91,4% por no haber recibido un Curso de Pacientes Especiales durante su formación académica; 25,9% porque requiere mucho tiempo y paciencia y 69% por no poseer las condiciones emocionales. Por otro lado, el 4% de los encuestados respondieron si atenderlos; bajo alguna forma de contención, sedación o de ser el caso referirlos a un especialista. El 23% restante de CDs indicó prestar atención solamente si eran pacientes colaboradores. Conclusiones:La odontología para pacientes con necesidades especiales en el estado de Rio Grande do Sul-Brasil parece no cubrir los requerimientos de estos pacientes, no solo por las dificultades inherentes a los servicios y las especificidades de dichos pacientes, sino debido a los impedimentos relacionados con los propios dentistas, problemas con las técnicas odontológicas y por toda la complejidad que envuelve la atención a personas con deficiencia.
Tratamiento ortodóncico de camuflaje de una maloclusión de Clase III. Reporte de caso
Authors: Ypanaque Ramirez Loidy Liceth , Luque Luque Hugo Javier
Published: March 2019

Desde el punto de vista ortodóncico y maxilofacial, una maloclusión con desarmonía esqueletal compleja, puede ser abordada con un enfoque ortopédico, ortodóncico y/o ortoquirúrgico; sin embargo, en pacientes adultos que rechazan la opción quirúrgica, la ortodoncia de camuflaje es la única opción disponible. Este artículo reporta el tratamiento de camuflaje ortodóncico de un paciente masculino de 21 años y 2 meses con un patrón esquelético de Clase III ángulo bajo, mordida bis a bis y tercio facial inferior disminuido. El uso de un arco utilitario de protrusión, bloques de acrílico posterior, elásticos intermaxilares de clase III, arco multiloops y stripping inferior fueron utilizados. Después de 26 meses de tratamiento, se logró una relación molar y canina de Clase I, overbite y overjet funcional, reducción de la proyección del labio inferior y mayor exposición de incisivos superiores en sonrisa con un perfil facial más agradable. Se realizó un control de 11 meses postratamiento revelando estabilidad de los resultados obtenidos.
Relación miofuncional y tratamiento de ortodoncia en paciente con síndrome de Turner. Reporte de caso
Authors: Leiva Noemi , Fuentes Vanessa , Ayala Francisca , Stange Carolina
Published: March 2019

El síndrome de Turner es un desorden cromosómico, generado por la pérdida parcial o total de un cromosoma X. Las mujeres que lo presentan, pueden tener una serie de alteraciones físicas y funcionales. El objetivo de este estudio es exponer el caso de una paciente con diagnóstico de síndrome de Turner, hipotonía muscular y maloclusión severa que fue tratada con terapia muscular craneofacial, combinada con ortodoncia en la Unidad de Malformación Craneofacial de la Facultad de Odontología de la Universidad de Chile.
Kontrolingo rūšių ir modelių vertinimas, kaip pagrindas kuriant veiksmingą informacinę kontrolingo sistemą įmonėje
Authors: Tamulevičienė Daiva
Published: March 2019

[full article and abstract in Lithuanian; abstract in English]

In order to solve issues of a company’s daily activities and predict further development directions in the current conditions of the ever-changing market environment, it is crucial for managers to have the right information at their disposal. Both the excessive information and the lack of it constitute the basis for inefficient or even disastrous decisions. Controlling is an efficient informative system that can provide managers with data needed for efficient management decisions. A properly designed controlling system can provide various information on all the areas of activity. Thus, when creating such a system, it is important to evaluate the possibilities of a controlling system, which are best revealed by a controlling system analysis and evaluation. The article analyzes the possibilities of information provided by a controlling system in terms of of evaluating controlling types and models. Such an evaluation creates possibilities to perform a cross-cut analysis of the characteristics of the provided information and define what is the content and scope of information that managers receive from a controlling system.

The article reveals that in the context of information provision for a company, strategic and operational controlling are to be considered the most significant ones. Strategic controlling provides information on how to do the right activity, whereas operational controlling – on how an activity can be done right. The goals of a company can be achieved only through both of them. Tactical controlling is what connects strategic controlling to operational controlling; its paradigm can be expressed through two questions: 1) how to do the right activity right? 2) what should be done when a wrong activity is being done or the activity is being done wrongly? Information provision for the answers to these questions would ensure a direct relation and feedback of strategic and operational controlling. After analyzing the typologization of controlling based on its origin, it was identified that the two main schools of controlling practice exist that led to the development of two different models of controlling: the Anglo-Saxon (American) and European (German). An exemplary controlling model adapted for Lithuanian companies was prepared after comparing the American and German controlling models and evaluating them on the basis of the scope of tasks, dominant orientation, the role of the controller, and the information base. On the basis of this adapted model, an individual information provision controlling system can be created for any Lithuanian company. This article analyzes other types of controlling as well, evaluation of which is important when creating an efficient system for controlling information provision in a particular company.
Síndrome de Agotamiento Profesional y Trabajadores Penitenciarios Peruanos. Una Mirada Cualitativa a los Factores Institucionales y Sociales
Authors: Bracco Bruce Lucia , Váldez Oyague Raúl , Wakeham Nieri Andrea , Velázquez Tesania
Published: March 2019

El artículo presenta los resultados de una investigación cualitativa a nivel nacional acerca de los factores institucionales y sociales asociados al Síndrome de Agotamiento Profesional (SAP) y al estrés laboral en trabajadores penitenciarios peruanos. Se realizaron 21 entrevistas a autoridades del Instituto Nacional Penitenciario del Perú (INPE) y 12 grupos focales con 59 trabajadores de las áreas de tratamiento y seguridad, de diez establecimientos penitenciarios (EP) a nivel nacional. Se encuentran como factores institucionales y sociales principales: (a) variables políticas y económicas estructurales de instituciones públicas, (b) relaciones interpersonales laborales, y (c) percepción del interno/a. Finalmente, se enfatiza en la comprensión multidimensional del SAP donde se incorporen en el análisis aspectos políticos, sociales y subjetivos. De manera particular, el artículo aporta en cómo la percepción de los internos, desde los trabajadores penitenciarios, podría estar impactando en la prevalencia del SAP y los objetivos institucionales.
El Capital Psicológico Positivo y su Relación con Comportamientos Discrecionales en Trabajadores de Lima, Perú
Authors: Bayona Hugo Andrés , Guevara Luis
Published: March 2019

Se evaluó la relación existente entre el capital psicológico positivo, las conductas de ciudadanía organizacional y las conductas contraproducentes de trabajo a través de un estudio transversal correlacional. Para esto se contó con una muestra de 137 trabajadores de diversas organizaciones de Lima, con una edad entre los 21 y los 63 años (M=36.51; DE=9.71). Los resultados mostraron relaciones directas entre el capital psicológico y las conductas de ciudadanía organizacional, así como relaciones inversas entre el capital psicológico y las conductas contraproducentes de trabajo. Además, se encontraron diferencias dentro de las variables a nivel de edad y experiencia laboral total. Los resultados aportan evidencia acerca de la importancia del desarrollo del capital psicológico dentro de las organizaciones para la generación de conductas deseables en el entorno de trabajo. Las limitaciones y recomendaciones son incluidas al final del estudio.
Importancia de la Diferenciación de Sí Mismo y el Ajuste Diádico en la Explicación de la Estabilidad Marital
Authors: Cabrera Victoria Eugenia , Herrera Calle Liliana Eloisa , Serrato Vásquez Consuelo
Published: March 2019

El objetivo de esta investigación fue explicar la estabilidad marital a partir de la diferenciación del yo y el ajuste diádico. Se contó con 262 participantes colombianos, hombres y mujeres con matrimonio civil o religioso, a quienes se les informaron las consideraciones éticas del estudio. Se aplicaron los instrumentos de Diferenciación del Sí Mismo, la escala de Ajuste Diádico e Inestabilidad Marital. Se corrieron ANOVAS, análisis de correlación y dos modelos de análisis de regresión lineal múltiple. Los resultados indicaron que los hombres muestran mayor reactividad emocional que las mujeres y que las personas con matrimonio civil se fusionan más y presentan menor nivel de consenso que las de matrimonio religioso. De acuerdo con los resultados de las correlaciones, en cuanto al sexo y tipo de unión, se encontró que a mayor ajuste diádico, mayor estabilidad marital. La cohesión es la dimensión que mejor explica la estabilidad marital, seguida de la satisfacción diádica.
Zarit Caregiver Burden Interview: Evidências de Validade para a População Brasileira de Cuidadores de Idosos
Authors: Queluz Francine Náthalie Ferraresi Rodrigues , Ferreira Campos Camila Rafael , Santis Ligia De , Isaac Letícia , Barham Elizabeth Joan
Published: March 2019

A Zarit Caregiver Burden Interview (ZBI) avalia a sobrecarga de cuidadores de idosos. Porém, ainda carece de evidências de validade para o contexto brasileiro, com cuidadores de idades variadas. Neste estudo, foram verificadas evidências de validade do ZBI –interna e baseadas nas relações com qualidade de vida e depressão–. No Estudo 1, participaram 285 cuidadores de idosos com idades entre 18 e 87 anos, que responderam à ZBI. No Estudo 2, 205 dos cuidadores do Estudo 1 também responderam ao Inventário de Depressão de Beck e à Escala de Qualidade de Vida. No Estudo 1, foram testados três modelos por meio de uma análise fatorial confirmatória e o alfa de Cronbach. No Estudo 2, foram medidascorrelações de escores na ZBI com escores de depressão e qualidade de vida. O modelo de três fatores se mostrou o maisadequado, apresentando bons índices de consistência interna. Foram observadas correlações negativas entre a ZBI e qualidade de vida e positivas com depressão. Portanto, este estudo contribuiu para o processo de validação da ZBI no Brasil, com cuidadores de faixa etária ampla.
Robust trajectory tracking control of omni-mobile robot with slipping of the wheels
Authors: Andreev Aleksandr S. , Peregudova Olga A.
Published: March 2019

In this paper we consider the problem of constructing a robust controller to track the trajectory of a mobile robot with three omni-wheels moving on a horizontal surface. A dynamic model of the robot has been constructed such that the center of mass of the circular platform is offset from its geometric center and the wheel slippage occurs during braking. The motion control of the wheeled robot is carried out by using three independent DC motors. The torques developed by the engines are linear with respect to voltage supplied to the engine and to angular velocity of the rotor. Basing on the Lyapunov function method we construct a bounded controller without velocity measurement that solves the robust trajectory tracking problem. This means that for all initial deviations the robot's trajectory falls into a given neighborhood of the tracked trajectory after some time and remains there forever. Theorem on an ultimate boundedness of a closed system is proved. The results of numerical simulation are presented confirming the effectiveness of the proposed controller.
On the smoothness of the solution of a nonlocal boundary value problem for the multidimensional second-order equation of the mixed type of the second kind in Sobolev space
Authors: Dzamalov Sirojiddin Z.
Published: March 2019

In this paper we prove the unique solvability and smoothness of the solution of a nonlocal boundary-value problem for a multidimensional mixed type second-order equation of the second kind in Sobolev space Wℓ2(Q), (2≤ℓ is an integer). First, we have studied the unique solvability of the problems in the space W22(Q). Solution uniqueness for a nonlocal boundary-value problem for a mixed-type equation of the second kind is proved by the methods of a priori estimates.Further, to prove the solution existence in the space W22(Q), the Fourier method is used. In other words, the problem under consideration is reduced to the study of unique solvability of a nonlocal boundary value problem for an infinite number of systems of second-order equations of mixed type of the second kind. For the unique solvability of the problems obtained, the ``ε-regularization'' method is used, i.e, the unique solvability of a nonlocal boundary-value problem for an infinite number of systems of composite-type equations with a small parameter was studied by the methods of functional analysis. The necessary a priori estimates were obtained for the problems under consideration. Basing on these estimates and using the theorem on weak compactness as well as the limit transition, solutions for an infinite number of systems of second-order equations of mixed type of the second kind are obtained. Then, using Steklov-Parseval equality for solving an infinite number of systems of second-order equations of mixed type of the second kind, the unique solvability of original problem was obtained. At the end of the paper, the smoothness of the problem's solution is studied.