bluuebunny/crossref_metadata_2025 huggingface dataset:
#083 Avaliação da má-oclusão (Baby-ROMA) na população pré-escolar do Distrito de Lisboa
Authors:   Faculdade de Medicina Dentária da Universidade de Lisboa, Leite Carina , Mendes Sónia ,   Faculdade de Medicina Dentária da Universidade de Lisboa, Bernardo Mário ,   Faculdade de Medicina Dentária da Universidade de Lisboa
Published: January 2025

Objetivos: Avaliação da necessidade de tratamento ortodôntico e do risco de má-oclusão na dentição decídua na população pré-escolar do Distrito de Lisboa, pela aplicação do índice Baby-ROMA (Risk Of Malocclusion Assessment). Métodos: Foi realizado um estudo transversal numa amostra aleatória e representativa da população-alvo, em 25 jardins- -de-infância do Distrito de Lisboa. Foram incluídas todas as crianças das escolas selecionadas com idades entre os 3 e os 6 anos, com dentição decídua exclusiva e com autorização dos responsáveis legais. A informação relativa ao Índice Baby-ROMA foi obtida através da aplicação de um questionário aos pais e de uma observação oral. O Baby-ROMA permite avaliar o risco de má-oclusão e a necessidade de tratamento ortodôntico na dentição decídua. Avalia parâmetros sistémicos, craniofaciais, dentários e funcionais que podem representar fatores de risco para o crescimento e desenvolvimento da região orofacial. Foi realizada uma análise estatística descritiva. Resultados: A amostra final incluiu 426 crianças com uma idade média de 4,2 anos. Verificou-se que 81% das crianças apresentavam um alto risco de má-oclusão, 10% um risco moderado e 9% um baixo risco. A necessidade de tratamento revelou-se ´Alta” em 28% da amostra, “Moderada” em 5% e “Baixa” em 67%. Os itens do índice Baby- ROMA mais frequentes foram os relacionados com problemas respiratórios, hábitos de sucção não-nutritivos, bruxismo e presença de cárie. Conclusões: A proporção de crianças com alto risco de má-oclusão verificou-se bastante elevada, principalmente devido à presença de situações preveníveis. Por este motivo, as necessidades de tratamento ortodôntico revelaram-se comparativamente mais baixas. Estes resultados enfatizam a importância da identificação dos fatores de risco modificáveis e implementação de medidas preventivas e intercetivas.
#107 Avaliação da Fluorescência de cinco resinas impressas em comparação com o dente natural
Authors:   Faculdade de Medicina Dentária da Universidade de Lisboa, Morgado Mariana , Correia Margarida ,   Faculdade de Medicina Dentária da Universidade de Lisboa, Lourenço Fábio ,   Faculdade de Medicina Dentária da Universidade de Lisboa, Duarte Inês ,   Faculdade de Medicina Dentária da Universidade de Lisboa, Viegas Diogo ,   Faculdade de Medicina Dentária da Universidade de Lisboa, Mourão João ,   Faculdade de Medicina Dentária da Universidade de Lisboa
Published: January 2025

Objetivos: Avaliar a fluorescência de cinco tipos de resinas híbridas impressas, comparando-as com a fluorescência do dente natural. Métodos: Foram produzidas 200 amostras de resinas híbridas, divididas em cinco grupos de 40 amostras, de acordo com as seguintes marcas: Freeprint Crown, Saremco Print Crowntec, VarseoSmile TriniQ, VarseoSmile Crown Plus e V- Print CB Temp, com recurso a uma impressora 3D da marca Asiga (Max UV). Após a impressão, as amostras foram lavadas, fotopolimerizadas e polidas. As amostras preparadas foram fotografadas com auxílio de um filtro de fluorescência e os valores de L*a*b foram registados no software Adobe Photoshop Lightroom. Após a determinação dos valores de L*a*b do dente natural selecionado e de todas as amostras, foi calculado o Delta E para cada amostra em relação ao dente natural. A análise dos dados foi realizada com o auxílio do software SPSS e os resultados foram comparados através de testes paramétricos. Resultados: Foram observadas diferenças significativas nos valores de Delta E de todas as resinas, exceto entre os grupos Freeprint Crown e VarseoSmile Crown Plus. Em relação ao dente natural, a resina Freeprint Crown apresentou o menor valor de Delta E, seguida por VarseoSmile Crown Plus, VarseoSmile TriniQ, V- Print CB Temp e por último Saremco Print Crowntec. Conclusões: As resinas Freeprint Crown e VarseoSmile Crown Plus apresentaram os menores valores de Delta E, aproximando-se mais da fluorescência natural do dente. Esta propriedade favorece significativamente o seu desempenho estético enquanto material restaurador.
#071 Terapia anti-inflamatória e edema facial após extração de terceiros molares – Estudo 3D
Authors:   Faculdade de Medicina Dentária Universidade de Lisboa, Pinto Ana , Caramês João ,   Faculdade de Medicina Dentária Universidade de Lisboa, Marques Duarte ,   Faculdade de Medicina Dentária Universidade de Lisboa, Pinto Ricardo ,   Faculdade de Medicina Dentária Universidade de Lisboa, Alves Rita ,   Faculdade de Medicina Dentária Universidade de Lisboa, Francisco Helena ,   Faculdade de Medicina Dentária Universidade de Lisboa
Published: January 2025

Objetivos: Comparar o efeito de duas terapias anti-inflamatórias no edema pós-operatório(2 e 7 dias) após cirurgia de extração de terceiros molares(3M) inclusos, através da utilização de um scanner facial. Métodos: Ensaio clínico aleatório cego como estudo piloto. Após aprovação pela comissão de ética e consentimento informado, foram incluídos 12 pacientes de acordo com critérios previamente definidos, com indicação para extração de 3M inclusos e distribuídos aleatoriamente ao grupo A(AINE-Ibuprofeno 600mg 8/8h 5 dias) ou grupo B(CORT AINE-Metilprednisolona 8mg 12/12h 3 dias Ibuprofeno 600mg 8/8h 5 dias). As intervenções foram realizadas pelo mesmo cirurgião, seguindo um protocolo cirúrgico padronizado. Os pacientes receberam os cuidados pós-operatórios, de forma verbal e escrita. Foram obtidos os dados demográficos dos pacientes( género e idade), duração da cirurgia(minutos) e a necessidade de osteotomia e/ou odontosecção.Os modelos faciais foram obtidos com o scanner RAYFace(RFS200,Ver. 2.1.13.2, RayCo.,Ltd,Korea), imediatamente antes, 2 e 7 dias após cirurgia( t0, t2 e t7, respetivamente), e sobrepostos pelo algoritmo de best fit por métodos previamente descritos(Geomagic Control X (3DSystems, USA).
Foram obtidos média e intervalo de confiança 95% de Root Mean Square (RMS) em micrómetros da zona intervencionada para edema pós-operatorio aos 2 dias (t0t2) e redução do edema pós-operatório aos 7 dias (t2t7), tendo sido realizados testes não paramétricos (amostras independentes de teste U de Mann-Whitney). Foi estabelecido o nível de significância a 0,05. Resultados: 12 pacientes com média de idades de 22,8 anos[17-39] foram submetidos a cirurgia com duração média de 19minutos[8-30]. Em t0t2 obtiveram-se valores médios de RMS de 1,51 /-0,64 para o grupo A e 1,71 /-0,61 para o grupo B, e em t2t7 de 1,14 /-0,47 para o grupo A e de 1,33 /-0,50 para o grupo B. Não foram detetadas diferenças estatisticamente significativas entre os grupos A e B para as variáveis em estudo (t0t2; t2t7 e percentagem de redução do edema). Detetou-se uma correlação positiva entre a duração da cirurgia e o tamanho do edema, embora sem diferença estatística (0,17). Após 7 dias verificou-se uma redução do edema de cerca de 75% e 78% nos grupos A e B, respetivamente. Conclusões: Neste estudo piloto não foram detetadas diferenças no edema pós-cirúrgico entre as duas terapêuticas anti-inflamatórias propostas. De forma a validar os resultados obtidos deve considerar-se aumentar a amostra.
The impact of phototherapy on quality of life in patients with chronic skin conditions: a systematic review
Authors: Aldayel Mohammad , Alosaimi Fahad , Alkathiri Saif , Alanazi Salman
Published: January 2025

Phototherapy is a cornerstone in the management of various dermatological conditions, including psoriasis, atopic dermatitis (AD), and vitiligo. Its impact extends beyond clinical improvements, significantly enhancing patients' quality of life (QoL). However, comparative data on different phototherapy modalities and their broader effects remain limited. This review evaluated the effectiveness of phototherapy in improving QoL, addressing disease severity, and reducing psychological burden across various dermatological conditions. A review of 11 studies conducted between the years 2016 and 2024 was performed to assess the impact of phototherapy, including narrowband ultraviolet B (NB-UVB), psoralen plus ultraviolet A (PUVA), and medium-dose UVA1, on QoL. The included studies encompassed diverse populations and settings, employing standardized tools such as the Dermatology Life Quality Index (DLQI), Psoriasis Area Severity Index (PASI), and other validated scales for severity and psychological assessment. Phototherapy demonstrated significant improvements in QoL across all included studies. A meta-analysis showed a significant reduction in the DLQL score by 8.586 (95% CI: 7.394-9.778, p< 0.001). Symptom-specific relief, particularly for pruritus, further enhanced QoL, as evidenced by a 7.3-point improvement in itch-related QoL scores. Comparative analyses revealed that biological therapies had superior QoL benefits; however, phototherapy remained an effective and accessible alternative. Phototherapy significantly improved QoL in patients with chronic dermatological conditions by addressing physical symptoms, psychological burden, and disease severity. It remains a cost-effective and accessible treatment, particularly in resource-limited settings. Future research should focus on long-term outcomes, standardization of QoL assessments, and comparative cost-effectiveness with biologic therapies to optimize patient care.
Mössbauer spectroscopy of ore-forming chromium spinels of the Polar Urals
Authors: Shiryaev P. B. , Vakhrusheva N. V.
Published: January 2025

Research subject. The work studied the heterogeneity of the chemical and phase composition of chromitites and ore-forming chromium spinels of the Polar Ural massifs Rai-Iz and Voikaro-Syninsky. Its influence on the value of the oxidation state of iron (Fe# = Fe3+/(Fe3+ + Fe2+)), determined by the calculation method, from the stoichiometric formula of the mineral, and using Mössbauer spectroscopy, is analyzed. The purpose of the study is to determine the degree of influence of various manifestations of the heterogeneity of the chemical composition of spinel on the results of determining Fe3+/(Fe3+ + Fe2+) using Mössbauer spectroscopy. Methods and materials. Monofractions of ore-forming chromium spinels were studied by Mössbauer spectroscopy (SM2201 spectrometer). The study of the heterogeneity of chromium spinel grains was carried out using microprobe analysis (electron probe microanalyzer Cameca SX-100) in polished sections and blocks, as well as X-ray phase analysis (powder diffractometer SHIMADZU XRD-6000) in samples analyzed on a Mössbauer spectrometer. Results. The studied ore-forming spinels exhibit three types of compositional heterogeneity, which determine the Fe#Möss– Fe#stoich discrepancy and influence its value: 1) chemical zoning of grains; 2) multiphase, associated with the presence of two generations of mineral grains with varying degrees iron oxidation; 3) hidden multiphase, manifested in broadening of diffraction peaks. In all cases, there is variability in the degree of iron oxidation in the mineral grains. Conclusions. The studied ore-forming spinels of the main ore bodies of the Rai-Iz massif and the northern part of the Voykar-Synya massif have a normal, unconverted structure, and the distribution of cations over its positions corresponds to the crystal chemical formula. Deviations in the distribution of iron cations, established during the study of the mineral by Mössbauer spectroscopy, are associated with the chemical heterogeneity of its grains and the presence in the ore of several spinel phases of different compositions.
Mineralogy and genesis of apocarbonate serpentinites of the Pitkäranta mining district, Northern Ladoga region. Part 1. Ophicalcite of the Hopunvaara ore field
Authors: Bulakh M. O. , Baksheev I. A. , Yapaskurt V. O.
Published: January 2025

Research subject. Serpentinites of the apocarbonate type in the contact aureole of the Salmi Batholith. Aim. Mineralogical and genetic description of the calcite-serpentine rocks of the Hopunvaara ore field. Materials and methods. Thirty samples of ophicalcite were studied using scanning electron microscopy, electron probe analysis, powder X-ray diffraction, FTIR and Raman spectroscopy, as well as differential thermal analysis. Results. The ophicalcite of the Hopunvaara ore field is represented by two types. The first variety was studied on samples from the Izvestkovyi quarry (“Lime Break”). It consists of thin-fibrous aggregates of clinochrysotile and lizardite (or only lizardite) intergrowing with calcite, with subordinate amounts of phlogopite and fluorapatite, as well as with veins of magnetite. Serpentine contains a small amount of impurities – up to 1.0 wt % FeO, up to 0.7 wt % Al2O3 and not more than 0.1 wt % MnO. Calcite is chemically pure. Ophicalcite of the second type, described in the Klara mining, is composed mainly of lizardite, which forms complete pseudomorphs after crystals of forsterite and/or minerals of the humite group enclosed among a carbonate matrix. Serpentine contains 0.4–2.5 wt % FeO, 0.0–1.6 wt % Al2O3, 0.1–0.2 wt % MnO, and 0.9–2.1 wt % F. In the carbonate matrix, along with almost pure calcite, there is dolomite containing 1.4 wt % MnO. Minor minerals are represented by fluorite, phlogopite and sphalerite. Such a rock is sectioned by antigorite-carbonate-fluorite-hematite veins with cassiterite, the formation temperature of which is estimated at 300–350°C. Conclusions. The formation of ophicalcite of the first type occurred through the interaction of dolomite with acidic SiO2-rich 200–300°C hydrothermal solutions. The microfiber structure of apodolomite serpentine aggregates is due to the mechanism of their crystallization in a porous medium that occurs during carbonate leaching. Ophicalcite of the second type was formed as a result of serpentinization of forsterite calciphyres at the regressive stage of skarnification process at T < 370°C.
Subduction and rifting ‒ reflect of oscillatory tectonic processes on boundaries of the lithosphere segments in the probable-deterministic gravity models
Authors: Petrishchevsky A. M.
Published: January 2025

Research subject. Convergent boundaries of the Euroassian, North American, Pacific lithosphere plates and protooceanic plate of the South China Sea on the Eastern Asia. Aim. On the base of tectonic analysis of 3D rheological gravity models compared with another geologic-geophysical data to study deep structures in zones of joint of lithosphere plates and to define space-time relations between subducton and rift structures. Material and Methods. Land and seas gravity measurements on the Russian territory and Land Gravity Data.bgi.omp.obs-mip.fr, model: EGM08_CBA_global_2190_2.5m on the territories of South East China and Sea of Japan were used. Main method of research is the gravity method for modeling of rheological properties of the crust and upper mantle by distributions of the density contrast (differentiation) of geological media (authors method). Results. Analysis of 3D distributions of density inhomogeneities in a tectonosphere of the North East Russia, Japan Sea Region, Sikhote Alin and South East China is carried out, as a result of which in the Eastern margin of Asia identical traces of tectonic processes on boundaries of the lithosphere plates, reflected their directed-oscillatory character are revealed. Traces of the subduction processes has been founded in a shape of inclined rigid sheets (slabs) reflected by maximums of the density contrast and moved under continental margin and island arcs. However the subduction was not constant in time and periodically was interrupted by kickbacks and gaps of subducting slabs under influence of rifting and transform-shift processes. In time the rifts and attendant their shifts have been displaced in a direction from autochthonous to allochthonous segments: in the North East Asia from North Asian Craton to North American plate, on the Eastern Asia – from the continent to Pacific, and on the South East Asia – from the South China Sea Plate to Yangtze plate. Conclusions. Revealed features of a structure and geodynamic evolution of convergent zones are universal characteristics of upper rigid layers of the Earth (crust and lower lithosphere) moved above subcrustal viscous layer and astenosphere under influence of the oscillation tensions, caused, most likely, by deviation of the Earth rotation parameters. In all of four areas identical sequence of subductional and rifting processes has been revealed. A subduction accompanied by thrusting of the upper crust layer over autochthonous segments was repeatedly interrupted by gaps of crustal and lithosphere sheets and a formation of stretch-shift structures. Sudduction is not main and defining process in the convergent boundaries of lithosphere plate, bat represents a privet element of the oscillatory tectogenesis.
New Early Frasnian stratas on the Middle Timan (Tsil’ma River basin)
Authors: Shumilov I. Kh. , Telnova O. P.
Published: January 2025

Research subject. Rocks and paleontological fossils (spores of higher plants) of early Frasnian sedimentation within the Tsil’ma area (Middle Timan). Material and methods. The lithological and biostratigraphical methods were used to identify and describe lithological stratons, determine the composition of spore complexes of higher plants characteristic of each straton in the early Frasnian outcrops of the Tsil’ma area, as well as to correlate the latter with the zonal patterns of the Devonian of the East European Platform. Results. In the Middle Timan, within the Tsil’ma area, new stratons were described in various structural and facies zones, i.e., the Brusnichnaya, Rudyanskaya, and Paladinskaya formations, characterizing the early Frasnian period of sedimentation. The identified stratons have distinct lithological and palynological characteristics. A description of limitotypes and composite stratotypes was carried out. Conclusions. At present, the Brusnichnaya, Rudyanskaya, and Paladinskaya formations are the most complete sequence of early Frasnian sedimentation in the European North-East of Russia. Here, regional responses to the global events of Frasnes (soluta conodont zone) and Genundewa (rugosa conodont zone) are recorded. The formations are characterized by spore complexes; palynozones are correlated with conodont zones. This allowed correlation between the continental and marine early Frasnian deposits in the European North-East of Russia, along with establishment of their exact position in the Devonian stratigraphic scheme.
Depositional environment of the Middle- and Upper-Holocene sediments in the North-West of the Bol’shezemel’skaya tundra (in the Kuya river valley)
Authors: Golubeva Yu. V. , Marchenko-Vagapova T. I. , Isakov V. A.
Published: January 2025

Research subject. The Holocene alluvium, lake-bog and oxbow-lake sediments in the lower reaches of the Kuya river valley, the right tributary of the Pechora river (Nenets Autonomous Okrug, northwest of the Bol`shezemel`skaya tundra). Aim. Investigation of the morphological types of fluvial formations, their lithostratigraphic subdivision, and reconstruction of the environmental conditions of sedimentation. Materials and methods. The sediments texture and structure features of the floodplain-channel complex were studied by granulometric and mineralogical analyses. The morphostructural features of the relief were identified by high-resolution satellite imagery and an ArcticDEM digital relief model. The spore-pollen and diatom analyses and radiocarbon dating results are presented. Results. The lithotypes of Holocene sediments that make up the valley in the lower reaches of the Kuya River are distinguished, and the chronology of paleogeographic events in the study area is presented. A geological and geomorphological scheme of the floodplain-channel complex of the Kuya River valley is constructed. The geological profile of alluvium and underlying sediments is constructed. Reconstructions of vegetation and climate dynamics in the mid- and late-Holocene based on the palynostratigraphic subdivision of alluvium sediments is carried out. The lower boundary of the late Sub-Atlantic period, correlated with the Little Ice Age, is clarified. Conclusions. The formation of the floodplain-channel complex occurred in four stages, with its constituent deposits being attributed to the channel, lacustrine, bog, and floodplain facies. According to morphometric features in the geomorphological structure of the river valley, an erosion-accumulative relief of the above-floodplain terraces of high and low floodplains is identified. The following stages of vegetation changes are traced: from tundra communities in the coldest conditions of the early Subboreal, which were replaced by forests of the middle taiga type to the Subboreal thermal maximum, dated 3360 ± 70 years ago (3602 cal. BP) to modern forest-tundra and south-tundra communities. The formation fluvial plain sediments occurred in shallow, slightly mineralized, and waterlogged reservoirs.
Depenalization of Medical Personnel Practicing Without a Practice License After the Enactment of the 2023 Health Law
Authors: Manuaba Ida Ayu Lidya Nareswari , Potabuga Siska Dewi Indriani , Lamawatu Nuril F.
Published: January 2025

The background of this research is that a doctor, as a medical professional, plays a crucial role in the healing process of patients based on knowledge and competence. The issue of doctors practicing without a valid practice license (SIP) has often been heard before the enactment of Law Number 17 of 2023 concerning Health, where the regulation on criminal sanctions for doctors practicing without an SIP was found in Law Number 29 of 2004 concerning Medical Practice. However, after the enactment of Law Number 17 of 2023 concerning Health, the regulation on criminal sanctions has been removed, leaving only administrative sanctions in effect. This research aims to explore the concept of depenalization for medical personnel practicing without a valid practice license after the enactment of Law Number 17 of 2023 concerning Health. The type of research used in this study was normative research, employing both a statutory approach and a conceptual approach. The findings of the study indicate that if the actions of the doctor can be proven in a factual judgment (judex facti), the concept of depenalization with the imposition of criminal sanctions should be considered, while setting aside the principle of economic deterrence.
Effect of Magnesium Sulfate (MgSO4) Administration on Nitric Oxide and Prostacyclin Levels in Preeclampsia
Authors: Pangkahila Evert , Kade Yudi Saspriyana  , Clara Amanda  , Winty Septiani
Published: January 2025

Introduction :  Preeclampsia is a pregnancy-related syndrome with significant maternal and neonatal risks, affecting 4.6% of pregnancies globally. Its pathophysiology, linked to an imbalance between prostacyclin (a vasodilator) and thromboxane (a vasoconstrictor), remains poorly understood. Magnesium sulfate (MgSO4) is widely used for seizure prophylaxis in preeclampsia, but its effect on nitric oxide (NO) and prostacyclin levels is still debated.
Methods: This quasi-experimental study included 30 pregnant women diagnosed with severe preeclampsia. Baseline serum levels of NO and prostacyclin were measured before MgSO4 administration and re-evaluated after 24 hours of treatment. Changes in biomarker levels were assessed using paired t-tests, with a significance threshold of p < 0.05.
Results: The mean NO level increased from 35.2 ± 5.6 µmol/L before treatment to 49.8 ± 6.3 µmol/L after MgSO4 administration, showing a statistically significant difference (p < 0.001). Similarly, prostacyclin levels rose from a baseline of 42.1 ± 4.8 pg/mL to 58.7 ± 5.2 pg/mL post-treatment (p < 0.001). These findings suggest a robust enhancement of vasodilatory activity, supporting the role of MgSO4 in improving vascular endothelial function.
Conclusion: MgSO4 administration significantly increases NO and prostacyclin levels, demonstrating its efficacy in reducing vascular resistance in preeclamptic pregnancies. These results reinforce its clinical utility, offering a mechanistic insight into its vasodilatory and anti-convulsive properties.
Keywords: Preeclampsia, magnesium sulfate, nitric oxide, prostacyclin, vascular biomarkers
Genital Ambiguity in a 46, XY individual : a Rare Case
Authors: Zata Yuda Amaniko  , Yuad Haviz
Published: January 2025

Introduction: Ambiguous genitalia/disorders of sexual development (DSD) is a disorder of sexual development that is atypical chromosomally, gonadally and anatomically, which is generally characterized by the presence of unclear external genitalia, which can cause biological, social and psychological problems in the patient. as well as family.
Objective: To report a rare case of 46 XY disorders of sexual development.
Case Report: A 20 years old patient was reported with complaints of primary amenorrhea, breasts that had not yet grown and genitals resembling male genitals. Through physical examination, fine hair appeared above the lips, acne, prominent thyroid cartilage, mammary tanner stage M1, and a structure resembling a penis on the genitalia. The patient was examined according to the algorithm for patients with DSD, namely an ultrasound examination with the result that no gonads were found, then the patient underwent a karyotyping examination with results of 46 XY. In the investigation, it revealed LH: 58.45 mIU/ml, FSH: 57.74 mIU/ml, testosterone: 228 ng/dl. Next, the patient is planned for further imaging examinations.
Conclusions: DSD is genetically heterogeneous and careful assessment by a multidisciplinary team is essential to accurately diagnose DSD. Many forms of DSD go undiagnosed. It is important for physicians to have a clear decision-making pathway in evaluating patients with DSD
Keywords: Disorders of Sexual Development, Ambiguous Genitalia, 46 XY
The Role of Endothelial Nitrit Oxide in Preeclampsia Onset
Authors: Ramya Sausan  , Yusrawati Yusrawati , Karmia Hudila Rifa
Published: January 2025

Background: Preeclampsia is a pregnancy-specific hypertensive disorder associated with significant maternal and fetal morbidity and mortality. Endothelial dysfunction plays a critical role in the pathogenesis of preeclampsia, with nitric oxide (NO) being a key regulator of vascular tone and endothelial function. This study aims to investigate the relationship between endothelial nitric oxide (eNOS) levels and the onset of preeclampsia.
Methods: A cross-sectional study was conducted on pregnant women diagnosed with severe preeclampsia and receive treatment at Dr. M. Djamil Hospital, Padang. After met the inclusion criteria and do not have exclusion criteria, demographic and clinical data was taken. Maternal plasma concentrations of eNOS were determined by ELISA. Non-parametric statistics were used for analysis.
Results: The study evaluated the levels of endothelial nitric oxide synthase (eNOS) in two groups of preeclampsia patients: those with Early Onset Preeclampsia (EOP) and Late Onset Preeclampsia (LOPE). The median eNOS levels were 50.43 pg/ml for the EOP group (range: 28.72 - 232.78 pg/ml) and 54.76 pg/ml for the LOPE group (range: 15.39 - 235.70 pg/ml). A Mann-Whitney U test revealed a p-value of 0.303, indicating no statistically significant difference in eNOS levels between the two groups. This suggests that the timing of preeclampsia onset does not significantly influence eNOS levels, providing insights into the disease's mechanisms.
Conclusion: eNOS levels in the early preeclampsia (EOP) group were found to be lower compared to the late preeclampsia (LOPE) group. Although there was a difference in eNOS levels between the two groups, the difference was not statistically significant.
Keywords: Preeclampsia, endothelial dysfunction, nitric oxide; pregnancy, hypertensive disorders
Clinical Profiles and Outcomes of Patients With Placenta Accreta Spectrum at Dr. M. Djamil Hospital, Padang During 2019 –2022
Authors: Sriyanti Roza , Sri Rahayu MK
Published: January 2025

Objective: Placenta accreta spectrum (PAS) is one of the severe obstetric complications which can cause serious morbidity and mortality to both maternal and neonatal. The incidence of PAS increases globally because of the increasing rate of cesarean deliveries (CS). The aim of this study was to describe the clinical profiles and outcomes of patients with PAS during 2019-2022 at Dr. M. Djamil Hospital, Padang.
Method: This study was a retrospective descriptive study that had women with PAS who gave birth and referred to Dr. M. Djamil Hospital Padang, from January 2019-December 2022 as study participants. This study described clinical profiles, PAI score and USG findings and maternal neonatal outcomes of patients with PAS.
Result: One hundred eighty-seven cases were involved in this study. Most women with PAS aged ≥ 35 years (45%), parity 2 (47%), previous CS (96%), ≥ 2 times CS history (59%). A PAI score ≥ 5 has the higher proportion (66%) than a PAI score <5. There were still 53 patients (28%) who were admitted in intrapartum and postpartum. Most of the participants underwent hysterectomy (74%).
Conclusion: Advanced maternal age, multiparity, previous CS, and placenta previa were risk factors for PAS. PAI score, which combines previous CH hostory and USG findings in antenatal care, can assist in determining whether pregnant women have a high risk of PAS. Antenatal diagnosis and proper perioperative management in PAS are needed to optimize maternal and neonatal outcomes.
 Keywords: Placenta accreta spectrum, clinical profiles, Outcomes
Judges’ Considerations in Deciding Mangrove Timber Smuggling Cases
Authors: Ramadhani Deaf Wahyuni
Published: January 2025

Mangrove forests in Indonesia constitute 23% of the world’s mangrove ecosystem. This has an impact on the high rate of mangrove production in Indonesia which triggers export smuggling. In fact, the prohibition on export smuggling has been regulated in Article 102A letter e of the Customs Law. Accordingly, this study aims to analyze the judges’ considerations in deciding mangrove export smuggling cases. This doctrinal legal research applied a case approach and used secondary data obtained from library materials through literature study. The collected data were then analyzed deductively. Analysis of the verdict on mangrove export smuggling cases found that the judges’ considerations had paid attention to the preservation of natural resources, but were not yet oriented towards the preservation of mangrove ecosystem, and the penalties applied were still minimum.
Marine Plastic Pollution Handling Based on International and Indonesian Law to Support Sustainable Development Goals
Authors: Yuliantiningsih Aryuni , Suherman Ade Maman , Jati Baginda Khalid Hidayat
Published: January 2025

Due to the increasing level of marine plastic pollution, the handling to preserve and protect the sea is urgently needed. Accordingly, this study discusses about the handling of marine plastic pollution based on international and Indonesian law. The normative juridical research method with a statute and analytical approach was used to analyze the secondary data descriptively. Based on the analysis, it was known that the prevention and handling of marine plastic pollution have not been specifically regulated in international law, both in hard law and soft law. Yet, there was a UNEA Resolution 4/15 of 2022 promoting the formation of international agreements to handle plastic pollution. Meanwhile, in Indonesian law, the handling of marine plastic pollution is generally regulated in the Law of the Sea. Specifically, it was regulated in Presidential Regulation No. 2018 on Marine Debris Management which is complemented by a National Plan of Action from 2018-2025 to reduce up to 70% of plastic debris in the sea. Efforts to prevent and handle marine plastic pollution at international and national levels are in line with the 14th SDGs target to protect the sea from pollution
Green Investment as a Guarantee to Protect the Indigenous People’s Rights
Authors: Listyani Ajeng Aditya
Published: January 2025

Investment opportunities are opened as widely as possible to achieve community welfare, including land use mechanisms. However, this endangers the existence of Indigenous People's rights. Indigenous People have limited access to their lives and livelihoods through land use. Therefore, measures are needed to ensure the protection of Indigenous People's rights in line with investment implementation. This research aimed to identify and analyze the concept of green investment and the implementation of green investment as an effort to ensure the protection of the rights of Indigenous People. This research was normative juridical research with a statutory approach and concept approach. The data used was secondary data obtained from a literature study. The results showed that green investment focuses on how environmental balance is maintained amidst the implementation of investments. The concept of green investment in the land sector was realized by the division of land functions, the use of land in line with regional spatial plans, and the application of environmental insight in land use. In addition, the application of green investment could be a method to protect the rights of indigenous people and ensure the sustainability of economic growth
Legal Consequences of Abuse of Circumstances in Sale and Purchase Binding Agreement on Land and Building
Authors: Susilowardani Susilowardani
Published: January 2025

This study aims at understanding the legal consequences of abuse of circumstances (misbruik van omstandigheden) in sale and purchase binding agreement on land and building. This study used a descriptive-analytical method including the description, explanation, and analysis of the issues occurred, followed by drawing conclusions to find the correct answers as solutions to the problems being analyzed. The results showed that, in practice, incidents indicating a defect of will, such as fraud and duress, are often encountered. This can be referred to as abuse of circumstances or misbruik van omstandigheden, leading to the issue of the legal consequences of abuse of circumstances in sale and purchase binding agreement on land and building. Yet, regulation on misbruik van omstandigheden (abuse of circumstances) has not been established in law. The legal consequence of the transfer of land rights carried out based on abuse of circumstances is a violation of the subjective condition of the agreement, namely the agreement of the parties, so the agreement can be annulled. Considering the numerous cases of abuse of circumstances, the authorities are required to consider and formulate applicable law to further strengthen the doctrine of abuse of circumstances used by judges.
Впровадження принципів циркулярної економіки в контексті розвитку України на засадах сталості
Authors:   Національний університет «Чернігівська політехніка», Холодницька Алла , Кичко Ірина ,   Національний університет «Чернігівська політехніка», Дерій Жанна ,   Національний університет «Чернігівська політехніка»
Published: January 2025

У статті обґрунтовано необхідність впровадження концепції циркулярної економіки. Доведено доцільність переходу до 10 базових принципів циркулярної економіки, що сприятиме ефективному використанню ресурсів, декарбонізації, впровадженню енергоощадних технологій, створенню нових робочих місць, підтримці місцевих виробників, утилізації відходів та зменшенню їх утворення. Авторами опрацьовані результати опитування експертів, що було проведене в межах Всесвітнього економічного форуму щодо сприйняття глобальних ризиків (GRPS) та імовірності їх виникнення. Систематизовані основні ризики для України. Запропоновані кроки для поступового переходу до циркулярної економіки, зокрема: мінімізація відходів, раціональне використання природних ресурсів та зменшення забруднення довкілля, адаптація до зміни клімату, інвестування в розвиток відновлювальних джерел енергії, створення умов для зменшення соціальної поляризації та створення здорового середовища для життя.
Механізм державного регулювання розвитку людського потенціалу в умовах четвертої промислової революції
Authors:   Університет митної справи та фінансів, Саричев Володимир , Плавкова Дар’я ,   Університет митної справи та фінансів
Published: January 2025

У статті розглянуто ключові аспекти формування та реалізації механізмів державного регулювання розвитку людського потенціалу в умовах четвертої промислової революції (Індустрії 4.0). Окреслено вплив цифровізації, автоматизації та штучного інтелекту на сучасний ринок праці, включаючи зміну структури зайнятості та виникнення нових професій. Особлива увага приділяється ролі держави в підтримці населення в умовах технологічних змін, зокрема через політики соціального захисту, перекваліфікації та навчання протягом життя. Проаналізовано нові виклики для системи освіти та необхідність переходу до моделей, що забезпечують розвиток як технічних, так і соціальних навичок.

Актуальність дослідження визначається швидкими змінами, спричиненими четвертою промисловою революцією, що характеризується широким впровадженням цифрових технологій, автоматизації та штучного інтелекту. У цих умовах людський потенціал стає ключовим фактором конкурентоспроможності держави та суспільства, адже лише наявність висококваліфікованих кадрів може забезпечити стале економічне зростання. Однак для адаптації населення до нових умов необхідне ефективне державне регулювання, спрямоване на розвиток навичок та компетенцій, необхідних у цифровій економіці.
Evaluation of Clinical Characteristics and Predictors for Outcomes of In-Hospital Cardiac Arrest
Authors: Polyak Alexander , Tacon Phillip Ryan , Krom Zachary , Friedman Oren , Mirocha James , Matusov Yuri
Published: January 2025

Objectives:

In-hospital cardiac arrest (IHCA) is a common event for hospitalized patients with high rates of morbidity among survivors. The goal of this study was to evaluate clinical characteristics and compare expected versus observed outcomes of IHCA.

Material and Methods:

This was a retrospective study. Patient characteristics, IHCA outcome (return of spontaneous circulation [ROSC]), and neurologic outcomes (favorable outcome defined as cerebral performance category [CPC] score of 1 or 2 at discharge) were collected. The Good Outcomes Following Attempted Resuscitation (GO-FAR) score was applied retrospectively to patients preceding cardiac arrest and compared to actual outcomes.

Results:

There was a significant association between GO-FAR score and survival to discharge (P = 0.001) and GO-FAR score and CPC score (P = 0.0001). There was also an association of shorter IHCA duration and CPC score (P = 0.03). There was no association between GO-FAR score and likelihood of ROSC (P = 0.30).

Conclusion:

The GO-FAR score has an association with favorable outcomes after IHCA and may help inpatient physicians prognosticate expected outcomes before IHCA.
The diagnostic value of NR2 antibodies level in patients with chronic cerebral ischemia
Authors: Voznyuk Igor A. , Ponomarev Grigory V. , Kharitonova Tatyana V. , Gogoleva Ekaterina A. , Ovdienko Oksana A. , Sergeeva Tatyana V. , Lipatova Lyudmila V. , Sivakova Natalia A. , Dambinova Svetlana A. , Skoromets Alexander A.
Published: January 2025

Introduction. Hypertension, diabetes mellitus, atherosclerosis, and other risk factors for cardiovascular disease (CVD) contribute to the development of cerebral hypoperfusion and neurotoxicity, leading to recurrent transient ischemic attacks and cerebral infarctions. These processes are accompanied by the release of the NR2 peptide into the bloodstream and the production of antibodies to it. The use of NR2 antibodies to identify and assess the severity of chronic cerebral ischemia (CCI) and the risk of stroke can improve the quality of care for patients with risk factors for CVD.
Aim of the study. To examine the NR2 antibody levels in patients with different CVD risk factors and CCI of varying severity.
Materials and methods. In 107 patients (mean age 60.1 7.9 years, 62 women and 45 men), 1.5T magnetic resonance imaging in the T1, T2, and T2 FLAIR sequences was performed. White matter hyperintensity was assessed using the Fazekas scale, and the size of individual hyperintensity lesions was also estimated. Enzyme immunoassay was used to measure the serum level of NR2 antibodies.
Results. In patients with signs of CCI, serum NR2 antibody levels were significantly higher compared to the patients without cerebrovascular brain disease (p 0.05). That trend was observed both in compensated cerebral ischemia (p = 0.005) and in decompensated cerebral ischemia (p = 0.001).
Conclusion. The study results indicate that elevated NR2 antibody levels (2 ng/ml) can be considered a marker associated with the development and progression of cerebral ischemia in patients with risk factors for CVD. Further study of the NR2 peptide and NR2 antibodies in patients with CCI will help optimize the indications for magnetic resonance imaging and improve the interpretation of its results.
Autosomal recessive spastic paraplegias types 7 and 76
Authors: Rudenskaya Galina E. , Kadnikova Varvara A. , Ryzhkova Oksana P. , Dyomina Nina A. , Sharkova Inna V. , Polyakov Alexander V.
Published: January 2025

Introduction. Since 2017, the Research Centre for Medical Genetics has been conducting the first clinical and molecular study in Russia of a heterogeneous spastic paraplegia group based on the MPS high throughput sequencing method. Our group of molecularly diagnosed SPGs (types with known genes) includes 122 families with 22 SPG types. This article continues the publication series on the study results.
The study aimed to determine the proportion and analyze the clinical, molecular, and genetic characteristics of two autosomal recessive forms, SPG7 and SPG76, in a group of identified SPGs.
Materials and methods. We assessed three non-inbred Russian families: two with SPG7 (a non-familial and a familial case) and one with SPG76 (a non-familial cases). Molecular genetic methods included massive parallel sequencing (MPS) panel for spastic paraplegia, Sanger sequencing, and multiplex ligation-dependent probe amplification (MLPA)).
Results. SPG7 was detected in 2 families and accounted for 1.6% of the entire SPG group and 8.7% of the autosomal recessive subgroup (less than in several other studies). The compound heterozygous genotypes in both families included the most frequent mutation in the SPG7 gene, c.1529CT (p.Ala510Val); the allelic mutation in one case was a 4-exon deletion not previously described, while the other was a known mutation, c.228TC (p.Ile743Thr). Despite a similar age at onset (end of the 3rd4th decade), the symptoms were different: uncomplicated spastic paraplegia in the non-familial case, while in the affected brothers prevailed ataxia; in both families, brain MRI showed cerebellar atrophy. The SPG76 case is a rare one, especially in a non-inbred family, and the first in Eastern Europe. A total of 28 families, mostly inbred, have been described worldwide. Two new mutations were found in the CAPN1 gene in the compound heterozygous state: c.398_399insAGTGGTTCCGCCGGCC (p. Arg133Glnfs*39) and c.1535GA (p.Arg512His). Clinical features of the 30-year-old patient were typical, with onset at 20 years of age, spastic paraplegia and ataxia, and without brain MRI abnormalities.
Conclusion. The range of autosomal recessive SPGs in Russian patients includes both common and very rare forms occurring in non-inbred families. Of the 5 mutations found in the SPG7 and CAPN1 genes, 3 have not been previously described. Our observations demonstrate the close relationship between spastic paraplegia and ataxia and the significance of MPS and MLPA technologies in the diagnostics of SPG.
Clinical cases of endoscopic removal of endobronchial tumors
Authors:   MD, Professor, Head of the Department of Hospital Surgery and radiation diagnosis, M.K. Ammosov North- Eastern Federal University, Tobokhov A.V. , Pavlov I.E. ,   Head of the Endoscopy Department of the Clinical Diagnostic Center of the SAI RS(Y) Clinical Center at RH No. 1, M.E. Nikolaev Yakutsk National Medical Center, Fedotov V.N. ,   endoscopist, department of endoscopy, clinical diagnostic center of the SAI RS(Y) Clinical Center at RH No. 1, M.E. Nikolaev Yakutsk National Medical Center, Sleptsov K.N. ,   head of the surgical department No. 2 of the clinical center of the SAI RS(Y) Clinical Center at RH No. 1, M.E. Nikolaev Yakutsk National Medical Center, Sleptsov A.P. ,   PhD, doctor of cardiovascular surgery, Head of the Vascular surgery Department of the SAI RS(Y) Clinical Center at RH No. 1, M.E. Nikolaev Yakutsk National Medical Center, Nikolaev V.N. ,   associate professor of hospital surgery and radiation diagnosis, M.K. Ammosov North-Eastern Federal University
Published: January 2025

Endoscopic removal of 2 cases of benign tumors and 1 malignant tumor of the bronchus was performed in the endoscopy department of the Republican Hospital No. 1 – National Center of Medicine named after M.E. Nikolaev. The choice of the technique was based on the histological conclusion and videobronchoscopy materials. 2 formations were removed by loop electroexcision and 1 by argonoplasmic coagulation. All patients, without exception, had airway clearance restored with adequate ventilation of previously switched-off lung sections. Endoscopic methods are highly effective in the treatment of patients with bronchial tumors.
Keywords: benign tumors, lung cancer, endoscopic treatment, bronchial recanalization, diagnosis of neoplasms, tracheobronchial tree.
Asynchronous Swarm-Based Global Optimisation: Overcoming Premature Convergence to Produce Realistic Pt Nanoparticle Ensembles
Authors: Holland Julian , Makos Malgorzata , Zhang Difan , Kollias Loukas , Lee Mal-soon , Rousseau Roger , Glezakou Vanda , Skylaris Chris-Kriton
Published: January 2025

Swarm intelligence-based algorithms have proven successful in exploring a potential energy surfaces (PESs) of chemical systems. One of the major limitations to recent implementations of these algorithms is that they have been implemented serially. To overcome this limitation we present our asynchronously parallel global optimisations (GO) artificial bee colony (ABC) methodology: pyGlobOpt. Furthermore, we demonstrate methodologies to properly tune and enhance pyGlobOpt for system specific character by developing assessment criteria that could be applied to any form of ensemble generation. Using this criteria we were able to demonstrate how to overcome premature convergence, an issue pervading the GO of some systems with the ABC algorithm, using a clustering-based methodology. We demonstrate that the inclusion of our clustering methodology and properly tuned pyGlobOpt parameters can lead to a 5-fold increase in the number of unique low-energy structures found as well as more than halving the average energetic distance from the global minimum. we apply our refined methods to Pt nanoparticles, an important catalytic material for the evolution and reduction of hydrogen. We produce ensembles of thermodynamically relevant structures at different degrees of hydrogenation and compare to carefully selected experimental metrics. We culminate in demonstrating the potential of our software to be leveraged by exascale high performance computers by performing linear-scaling DFT calculations within the pyGlobOpt framework.