bluuebunny/crossref_metadata_2025 huggingface dataset:
Electronic nose homogeneous data sets for beef quality classification and microbial population prediction
Authors: Wijaya Dedy Rahman , Sarno Riyanarto , Zulaika Enny , Afianti Farah
Published: July 2022

Objectives

In recent years, research on the use of electronic noses (e-nose) has developed rapidly, especially in the medical and food fields. Typically, e-nose is coupled with machine learning algorithms to detect or predict multiple sensory classes in a given sample. In many cases, comprehensive and complete experiments are required to ensure the generalizability of the predictive model. For this reason, homogeneous data sets are important to use. Homogeneous data sets refer to the data sets obtained from different observations in almost similar environmental condition. In this data article, e-nose homogeneous data sets are provided for beef quality classification and microbial population prediction.

Data description

This data set is originated from 12 type of beef cuts. The process of beef spoilage is recorded using 11 Metal-Oxide Semiconductor (MOS) gas sensors for 2220 min. The formal standards, issued by the Meat Standards Committee, are used as a reference in labeling beef quality. Based on the number of microbial populations, meat quality was grouped into four classes, namely excellent, good, acceptable, and spoiled. The data set is formatted in "xlsx" file. Each sheet represents one beef cut. Moreover, data sets are good cases for feature selection algorithm stability test, especially to solve sensor array optimization problems.
Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report
Authors: Arabadjief Melissa A. , Elsayed Omar H. , Bashir Sabina , Gundumalla Meenakshi R. , Menefee Derek S. , Bergman Cody L. , Moulana Nayeem Z. , El-Mallakh Rif S.
Published: July 2022

Background

Ethanol dependence is associated with a discontinuation withdrawal delirium. Chlordiazepoxide is frequently successfully used in its treatment.

Case presentation

A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration.

Conclusions

Worsening of delirium appears to be related to the specific use of chlordiazepoxide, but the mechanism of this effect is not clear. While this case does not alter the standard care of ethanol dependence, it does alert clinicians that our treatment approach may not be fully benign.
Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway
Authors: Xiong Yuyan , Tang Ruijie , Xu Junyan , Jiang Wenyang , Gong Zhaoting , Zhang Lili , Ning Yu , Huang Peisen , Xu Jun , Chen Guihao , Li Xiaosong , Hu Mengjin , Xu Jing , Wu Chunxiao , Jin Chen , Li Xiangdong , Qian Haiyan , Yang Yuejin
Published: July 2022

Background

Bone marrow cells (BMCs), especially mesenchymal stem cells (MSCs), have shown attractive application prospects in acute myocardial infarction (AMI). However, the weak efficacy becomes their main limitation in clinical translation. Based on the anti-inflammation and anti-apoptosis effects of a Chinese medicine-Tongxinluo (TXL), we aimed to explore the effects of TXL-pretreated MSCs (MSCsTXL) in enhancing cardiac repair and further investigated the underlying mechanism.

Methods

MSCsTXL or MSCs and the derived exosomes (MSCsTXL-exo or MSCs-exo) were collected and injected into the infarct zone of rat hearts. In vivo, the anti-apoptotic and anti-inflammation effects, and cardiac functional and histological recovery were evaluated. In vitro, the apoptosis was evaluated by western blotting and flow cytometry. miRNA sequencing was utilized to identify the significant differentially expressed miRNAs between MSCsTXL-exo and MSCs-exo, and the miRNA mimics and inhibitors were applied to explore the specific mechanism.

Results

Compared to MSCs, MSCsTXL enhanced cardiac repair with reduced cardiomyocytes apoptosis and inflammation at the early stage of AMI and significantly improved left ventricular ejection fraction (LVEF) with reduced infarct size in an exosome-dependent way. Similarly, MSCsTXL-exo exerted superior therapeutic effects in anti-apoptosis and anti-inflammation, as well as improving LVEF and reducing infarct size compared to MSCs-exo. Further exosomal miRNA analysis demonstrated that miR-146a-5p was the candidate effector of the superior effects of MSCsTXL-exo. Besides, miR-146a-5p targeted and decreased IRAK1, which inhibited the nuclear translocation of NF-κB p65 thus protecting H9C2 cells from hypoxia injury.

Conclusions

This study suggested that MSCsTXL markedly facilitated cardiac repair via a new mechanism of the exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway, which has great potential for clinical translation.
One Health—One Biofilm
Authors: Jacques Mario , Malouin François
Published: July 2022

Bacterial biofilms are structured clusters of bacterial cells enclosed in a self-produced polymer matrix that are attached to a biotic or abiotic surface. This structure protects bacteria from hostile environmental conditions. There are also accumulating reports about bacterial aggregates associated but not directly adherent to surfaces. Interestingly, these bacterial aggregates exhibit many of the same phenotypes as surface-attached biofilms. Surface-attached biofilms as well as non-attached aggregates are ubiquitous and found in a wide variety of natural and clinical settings. This strongly suggests that biofilm/aggregate formation is important at some steps in the bacterial lifecycle. Biofilm/aggregate formation might therefore be important for some bacterial species for persistence within their host or their environment, while for other bacterial species it might be more important for persistence in the environment between infection of different individuals or even between infection of different hosts (humans or animals). This is strikingly similar to the One Health concept which recognizes that the health and well-being of humans, animals and the environment are intricately linked. We would like to propose that within this One Health concept, the One Biofilm concept also exists, where biofilm/aggregate formation in humans, animals and the environment are also intricately linked. Biofilm/aggregates could represent the unifying factor underneath the One Health concept. The One Biofilm concept would support that biofilm/aggregate formation might be important for persistence during infection but might as well be even more important for persistence in the environment and for transmission between different individuals/different hosts.
Masked multi-center angular margin loss for language recognition
Authors: Ju Minghang , Xu Yanyan , Ke Dengfeng , Su Kaile
Published: July 2022

Language recognition based on embedding aims to maximize inter-class variance and minimize intra-class variance. Previous researches are limited to the training constraint of a single centroid, which cannot accurately describe the overall geometric characteristics of the embedding space. In this paper, we propose a novel masked multi-center angular margin (MMAM) loss method from the perspective of multiple centroids, resulting in a better overall performance. Specifically, numerous global centers are used to jointly approximate entities of each class. To capture the local neighbor relationship effectively, a small number of centers are adapted to construct the similarity relationship between these centers and each entity. Furthermore, we use a new reverse label propagation algorithm to adjust neighbor relations according to the ground truth labels to learn a discriminative metric space in the classification process. Finally, an additive angular margin is added, which understands more discriminative language embeddings by simultaneously enhancing intra-class compactness and inter-class discrepancy. Experiments are conducted on the APSIPA 2017 Oriental Language Recognition (AP17-OLR) corpus. We compare the proposed MMAM method with seven state-of-the-art baselines and verify that our method has 26.2% and 31.3% relative improvements in the equal error rate (EER) and Cavg respectively in the full-length test (“full-length” means the average duration of the utterances is longer than 5 s). Also, there are 31.2% and 29.3% relative improvements in the 3-s test and 14% and 14.8% relative improvements in the 1-s test.
Virtual classes during COVID-19 pandemic: focus on university students’ affection, perceptions, and problems in the light of resiliency and self-image
Authors: Assi Elham , Rashtchi Mojgan
Published: July 2022

Although online learning has been studied extensively over the last two decades, students’ feedback toward such classes during the COVID-19 pandemic seems essential due to their effects on the education systems. The present exploratory sequential mixed methods study aimed to address university students’ affection, perception, and problems in online courses during the pandemic considering their resiliency and self-image. A 37-item virtual class Affection Perceptions, Problems, Resiliency, and Self-image Questionnaire (APPRSQ) was developed, validated, and administered online to 252 university Translation and TEFL-major students. The results demonstrated that the APPRSQ is a valid and reliable data gathering instrument. The participants’ answers to APPRSQ indicated that they were resilient and could adapt to the new learning mode. However, they preferred face-to-face classes, though they believed online courses were inevitable during the pandemic. Such courses had some advantages, such as enhancing students’ technological knowledge and helping them become autonomous. The triangulated data obtained from interviews with 20 students were analyzed. The results could provide a further understanding of APPRSQ factors. The study suggests that teachers and educational authorities improve the quality of online classes.
First record and morphological contributions of Procyrnea leptoptera (Rudolphi, 1819) (Nematoda: Habronematidae) in the kestrel Falco tinnunculus Linnaeus (Falconiformes: Falconidae) from Egypt
Authors: Haroun Sahar H. , Taha Rania G.
Published: July 2022

Background

The kestrelFalco tinnunculus, Linnaeus, 1758 is widely distributed in Europe, Asia, Africa, and East coast of North America. It is a predator species that belongs to family Falconidae. Nematode species of the genusProcyrneainfects the proventriculus and gizzard of the birds and may cause serious health hazards including inflammation, erosions, and ulcers for the infected gastric mucosa, general weakness and may lead to death. The present study aimed to improve the limited information regarding the endoparasites ofFalco tinnunculusin Egypt.

Results

Nine males and twenty-one female nematodes were identified asProcyrnea leptoptera, Rudolphi 1819, Chabaud 1958, isolated from the proventriculus of common kestrel;Falco tinnunculusgathered from El-Faiyum governorate, Cairo, Egypt, as a new geographical record. The isolated species has been studied morphologically by light and scanning electron microscopy. It was revealed that it is characterized by two lateral pseudolabia with dorsal and ventral labia. The pseudolabium is divided into 2 lobes at the internal side, a number of medium-size teeth (4–6) in the buccal cavity on the interior border of pseudolapia, in addition to the presence of transverse striations. Also, the histopathological effects of the isolated nematode on the liver of the infected host revealed severe damage in the bird's tissues and morphological alterations including infiltration of inflammatory cells, congestion, focal necrosis, and degeneration of hepatic cells.

Conclusions

Raptors likeFalco tinnunculusare infected with parasites via prey ingestion, so they are serving as intermediate hosts for many species of parasites. Due to the scarcity of studies for the helminth parasites of raptors in Egypt, further studies are needed to get additional precise data on the helminthic infection of raptors and their histopathological effects.
Undervalued and overlooked: the importance of private space in liaison psychiatry
Authors: Booker James , Cleak Victoria
Published: July 2022

Access to private space for psychiatric assessments is crucial to facilitate the effective gathering of salient information while preserving the dignity of patients. In this article, we discuss the current availability of private space for liaison psychiatry services on in-patient wards in general hospitals and reflect on how this affects communication with patients. Additionally, we propose solutions for healthcare trusts in addressing this issue.
Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma
Authors: Warde Kate M , Lim Yi Jan , Ribes Martinez Eduardo , Beuschlein Felix , O’Shea Paula , Hantel Constanze , Dennedy Michael Conall
Published: July 2022

Introduction

Adrenocortical carcinoma (ACC) is a rare aggressive cancer with low overall survival. Adjuvant mitotane improves survival but is limited by poor response rates and resistance. Mitotane’s efficacy is attributed to the accumulation of toxic free cholesterol, predominantly through cholesterol storage inhibition. However, targeting this pathway has proven unsuccessful. We hypothesize that mitotane-induced free-cholesterol accumulation is also mediated through enhanced breakdown of lipid droplets.

Methodology

ATCC-H295R (mitotane-sensitive) and MUC-1 (mitotane-resistant) ACC cells were evaluated for lipid content using specific BODIPY dyes. Protein expression was evaluated by immunoblotting and flow cytometry. Cell viability was measured by quantifying propidium iodide-positive cells following mitotane treatment and pharmacological inhibitors of lipolysis.

Results

H295R and MUC-1 cells demonstrated similar neutral lipid droplet numbers at baseline. However, evaluation of lipid machinery demonstrated distinct profiles in each model. Analysis of intracellular lipid droplet content showed H295R cells preferentially store cholesteryl esters, whereas MUC-1 cells store triacylglycerol. Decreased lipid droplets were associated with increased lipolysis in H295R and in MUC-1 at toxic mitotane concentrations. Pharmacological inhibition of lipolysis attenuated mitotane-induced toxicity in both models.

Conclusion

We highlight that lipid droplet breakdown and activation of lipolysis represent a putative additional mechanism for mitotane-induced cytotoxicity in ACC. Further understanding of cholesterol and lipids in ACC offers potential novel therapeutic exploitation, especially in mitotane-resistant disease.
The Legacies of Empire in Nwaubani's I Do Not Come to You by Chance and Mengestu's All Our Names
Authors: Musila Grace A.
Published: July 2022

While the Black Lives Matter movement is widely recognized and supported in Africa, its framing prioritizes experiences of anti-Blackness in the United States and the Black diaspora. This is partly owing to the movement's genesis as a direct response to domestic forms of anti-Blackness, including police brutality, disproportionate Black incarceration, and systemic inequalities, but also because, as Jemima Pierre argues, Africa is often perceived as “the site of racial otherness,” making engagements with racialization in Africa appear redundant. This paper considers how two contemporary African writers—Nigerian Adaobi Tricia Nwaubani and Ethiopian American Dinaw Mengestu—comment on anti-Blackness in Africa. This article views Nwaubani's I Do Not Come to You by Chance and Mengestu's All Our Names as using trickster figures to critique the racially inflected narratives of modernity, Euro-American imperialism, and neoliberal capital in Africa. In the process, they invite us to join the dots between domestic patterns of anti-Black violence in the Black diaspora and Euro-American destruction of African lives through the debilitating systems of slavery, colonialism, the Cold War, and neoliberal capital in Africa. The two novels’ portraits challenge the Black Lives Matter movement's thin engagement with anti-Blackness in Africa by demonstrating how historic and ongoing dehumanization of Africans serves to normalize similar dehumanization of Afro-descended people across the globe.
Form and the Anticolonial Novel: William Gardner Smith'sThe Stone Face
Authors: McCarthy Jesse
Published: July 2022

The category of the postcolonial novel is familiar, but what makes a novel anticolonial? This article attempts to answer this question by reconstructing a genealogy of anticolonial fiction. I argue that these novels are preeminently the product of a social and intellectual class that inherits Franco Moretti's novel of bourgeois subject formation with all the attendant problems and opportunities of traditional bourgeois realism, while seeking to replace the privileged place of irony in those texts with a partisan spirit of conviction. One consequence of this is a deeper investment in allegory and metonym, pressed into the service of a totalizing metaphor for the wholesale corruption of a society that must be entirely dissolved. Drawing on the work of Anne-Lise François, the article suggests that, more specifically, the history of decolonization and the literature that it engenders repeatedly figure torture, and scenes of torture, as the “open secret” that reveals the peculiar nature of social relations under colonialism. Examining these scenes closely reveals a set of problems for literary form that are inherent to the anticolonial novel of the postwar years of decolonization, recurring problematics that nonetheless make the case for its existence as a distinct genre. No novel better emblematizes this genre than William Gardner Smith's The Stone Face (1963). Smith's novel is read as an attempt to narrativize the problem of intersectionality for a revolutionary internationalism and to push back against some critiques of the novel, such as Paul Gilroy's, that have questioned the limits of its conception of solidarity and the function of racial blackness in its politics. The novel exemplifies, the article argues, both the greatest qualities and the greatest limitations of the anticolonial novel as a genre and offers an unromantic and ultimately sobering account of the ethical and aesthetic costs of revolutionary conviction.
High-Resolution Spinal Motor Mapping Using Thoracic Spinal Cord Stimulation in Patients With Chronic Pain
Authors: Telkes Ilknur , Hadanny Amir , DiMarzio Marisa , Chitnis Girish , Paniccioli Steven , O'Connor Katherine , Grey Rachael , McCarthy Kevin , Khazen Olga , McLaughlin Bryan , Pilitsis Julie G.
Published: July 2022

BACKGROUND:

High-resolution spinal cord stimulation (HR-SCS) paddle can stimulate medial-dorsal columns and extend stimulation coverage to the laterally positioned spinal targets.

OBJECTIVE:

To investigate the medio-lateral selectivity of an HR-SCS paddle in patients with chronic pain.

METHODS:

During standard-of-care spinal cord stimulation (SCS) placement, epidurally evoked electromyography and antidromic dorsal column–evoked potentials were recorded in 12 subjects using an HR-SCS paddle with 8 medio-lateral sites spanning the full epidural width at thoracic T9-12 and a commercial paddle consecutively.

RESULTS:

Recruitment maps were aligned with respect to physiological midline which was overlapping with anatomic midline in 10 of 11 cases. Overlapping contacts between the HR-SCS and commercial paddles exhibited similar patterns while HR-SCS demonstrated higher precision targeting of certain dermatomes. Spinal motor maps showed that the lateral contacts triggered stronger responses in medial gastrocnemius, adductor magnus, and tibialis anterior while the medial contacts triggered stronger responses in gluteus maximus and adductor hallucis. The time-locked popliteal fossa responses indicated ipsilateral activation by HR-SCS at the lateral contacts and bilateral activation at the medial contacts with stronger ipsilateral responses.

CONCLUSION:

This study is the first to perform high-resolution medio-lateral SCS mapping in patients with chronic pain. These results show promise that HR-SCS may provide additional ipsilateral recruitment within the extremities which improve targeting of focal pain in the lower extremities. Furthermore, this study supports the functional use of intraoperative neuromonitoring as a decision tool to determine physiological midline in thoracic SCS surgeries and provides a full methodological framework.
Enantioselective C–H Functionalization Using High-Valent Group 9 Metal Catalysts
Authors: Yoshino Tatsuhiko
Published: July 2022

Group 9 transition metals with a cyclopentadienyl-type ligand are highly reactive catalysts for directed C–H functionalization reactions. In this review, we summarize our recent work on the development of enantioselective C–H functionalization reactions using achiral Rh(III) or Co(III) catalysts in combination with an external chiral source such as chiral sulfonates, a Lewis base, or carboxylic acids.
Μελέτη της παρουσίας γηρασμένων κυττάρων στο μεσοσπονδύλιο δίσκο
Authors: Χαμηλός Χρήστος
Published: July 2022

Γενικό μέρος: H εκφύλιση του μεσοσπονδύλιου δίσκου συνδέεται άρρηκτα με τις βιοχημικές διαδικασίες γήρανσης των χονδροκυττάρων του δίσκου. Σε αυτή τη μελέτη γίνεται ανασκόπηση και μελέτη των μηχανισμών πρόκλησης εκφυλισμού - γήρανσης μεσοσπονδύλιου δίσκου. Επίσης αναλύονται και οι διάφοροι τρόποι θεραπευτικής προσέγγισης. Πειραματικό μέρος: Η πλειοψηφία των μελετών που αξιολογούν την παρουσία γερασμένων κυττάρων σε μεσοσπονδύλιους δίσκους in vivo έχουν βασιστεί στον ευρέως χρησιμοποιούμενο βιοδείκτη της κυτταρικής γήρανσης SA-β-gal που αφορά μόνο φρέσκα κύτταρα και ιστούς. Παρουσιάζεται για πρώτη φορά μία νέα διαδικασία αναγνώρισης γερασμένων κυττάρων GL13 που αφορά και τους σταθεροποιημένους ιστούς. Το ωσμωτικό στρες είναι σημαντικός παράγοντας γήρανσης – εκφύλισης του μεσοσπονδύλιου δίσκου. Μελετήθηκε για πρώτη φορά σε ανθρώπινο μεσοσπονδύλιο δίσκο η αντλία CLCA2 (calcium actvated chloride channel protein) που σχετίζεται με αυτό και φαίνεται να υπερεκφράζεται στους γερασμένους – εκφυλισμένους δίσκους. Χρειάζεται περεταίρω μελέτη και θα μπορούσε να αποτελέσει στο μέλλον φαρμακολογικό στόχο.
Μοναρχία
Authors: Αθανασίου Μιχάλης
Published: July 2022

Με την εργασία αυτή παρέχω μία ολοκληρωμένη εικόνα της θείας μοναρχίας στην αρχαιότητα, αναδεικνύοντας το φιλοσοφικό και θεολογικό της υπόβαθρο, αφενός, και τις πολιτικο-κοινωνικές προεκτάσεις της, αφετέρου. Συλλέγοντας από τη διεθνή βιβλιογραφία όλα τα δεδομένα της επιστημονικής προβληματικής σχετικά με τη μοναρχία στον ελληνορωμαϊκό κόσμο, παρακολουθώ συστηματικά την ανέλιξή της ως πολιτικής ιδέας, κατ’ αρχήν, και, κατόπιν, ως φιλοσοφικο-θρησκευτικής αρχής από την ομηρική εποχή έως τις παρυφές του Βυζαντίου. Δεν περιορίζομαι, μάλιστα, στην έκθεση των απόψεων των Ελλήνων και ξένων ερευνητών επί του θέματος αλλά τις σχολιάζω και τις αξιολογώ με βάση το πηγαίο υλικό που συγκεντρώνω. Πέραν τούτου, όμως, η σημαντικότερη συνεισφορά της παρούσας εργασίας στη σύγχρονη έρευνα έγκειται στο γεγονός ότι για πρώτη φορά διεθνώς υπογραμμίζεται σε μία επιστημονική εργασία ο νευραλγικός ρόλος που διαδραματίζει η μοναρχία στις δογματικές έριδες του 4ου αιώνα μ.Χ. ως ‘’μήλον της έριδας’’ μεταξύ Αρειανών και Ορθοδόξων. Συνεκδοχικά, το ζήτημα της διαφορετικής κατανόησης του όρου μοναρχία από τα αντίπαλα στρατόπεδα που συγκρούονται μεταξύ τους για τον καθορισμό του εκκλησιαστικού δόγματος την εποχή μετά τον Κωνσταντίνο, αφήνει ανοικτό το ερώτημα, κατά πόσον ο αρειανόφρων Ευσέβιος Καισαρείας συνιστά πράγματι τον θεμέλιο λίθο της πολιτικής φιλοσοφίας των Βυζαντινών, όπως επαναλαμβάνεται κατά κόρον στη ξενόγλωσση βιβλιογραφία από ειδικούς ποικίλων κλάδων της αρχαιογνωστικής επιστήμης – ιστορικούς, θεολόγους ή φιλόλογους. Τέλος, με τις μαρτυρίες που ανασύρω από την πατερική γραμματεία και τον σχολιασμό τους, δίνω αφορμή για μια ‘’φρέσκια ματιά’’ στη μοναρχία ως όρο της ορθόδοξης δογματικής θεολογίας για την περιγραφή των σχέσεων μεταξύ των προσώπων της Αγίας Τριάδας τόσο στο επίπεδο της θεολογίας όσο και της οικονομίας.
აგამემნონის სახე ბერძნულ ლიტერატურაში ჰომეროსიდან იანის რიცოსამდე
Authors: Δημοπούλου Γεωργία
Published: July 2022

Στόχος της παρούσας διδακτορικής διατριβής είναι η διερεύνηση του μύθου του Αγαμέμνονα σε ποιητικά κείμενα της αρχαίας ελληνικής και νεοελληνικής γραμματείας, η παρουσίαση της ιδιαίτερης μορφής του και η εξέτασή της από τον Όμηρο μέχρι και τον Γιάννη Ρίτσο. Μας ενδιαφέρει αφενός να φωτιστούν οι διαφορετικές πλευρές της προσωπικότητάς του, τα κίνητρα που τον οδηγούν στις εκάστοτε ενέργειες και αφετέρου να ανιχνευτούν οι λόγοι για τους οποίους, ενδεχομένως, επιλέγει ο κάθε δημιουργός να τον σκιαγραφήσει με συγκεκριμένο τρόπο. Σκοπός της εργασίας είναι να παρακολουθήσει πώς παρουσιάζεται στην αρχαία ελληνική γραμματεία ο Αγαμέμνονας· πώς επανακάμπτει η μορφή του στη νεότερη δραματουργία· σε ποια επίπεδα εντοπίζεται η σύγχρονη διαφορετικότητά του. Απώτερος στόχος είναι να ανιχνευτούν τα ιδεολογήματα εκείνα που πλαισιώνουν το συγκεκριμένο πρόσωπο και εκφράζουν τις ιδιαιτερότητες, τις επιλογές και τους προσανατολισμούς των σύγχρονων Ελλήνων δραματουργών.Πιο συγκεκριμένα, ο πρώτος στόχος της παρούσας μελέτης είναι η αποσαφήνιση κάποιων πληροφοριών σχετικά με τη μορφή του Αγαμέμνονα στα ποιητικά κείμενα της αρχαιοελληνικής γραμματείας, γιατί συχνά εμφανίζονται αντικρουόμενες πληροφορίες π.χ. για την καταγωγή του, τα μέλη της οικογένειάς του, τις συνθήκες του θανάτου του κ.α. Μάλιστα από τη μελέτη των κλασικών κειμένων είναι δύσκολη οποιαδήποτε ρητή απάντηση στα ερωτήματα της ενοχής και της αναγκαιότητας του τόσο φρικτού τέλους του Αγαμέμνονα, έχει ενδιαφέρον να δούμε τη θέση των κειμένων της νεοελληνικής λογοτεχνίας στα ερωτήματα αυτά και στην παρουσίαση ενός τόσο αμφιλεγόμενου χαρακτήρα. Ένας δεύτερος στόχος είναι ο εντοπισμός των κειμένων της νεοελληνικής λογοτεχνίας, στα οποία φιλοξενείται ο Αγαμέμνονας στη νεοελληνική διαδρομή του. Με εργαλεία τη θεματική ανάλυση και τη διακειμενικότητα θα γίνει προσπάθεια να ανιχνευτούν τα μοτίβα και τα μυθήματα και πώς αυτά σμιλεύτηκαν, ανασημασιοδοτήθηκαν και μεταγράφηκαν από τους δημιουργούς στα έργα τους. Είναι ζητούμενο της μελέτης αυτής να δούμε πώς συγκροτείται το ήθος του Αγαμέμνονα στα κείμενα, με δεδομένη την αρχή ότι ο λόγος είναι «η λεξική κρυστάλλωση του ήθους».
Realizacja charyzmatu trynitarskiego w Polsce
Authors: Kowalski Maciej J.
Published: July 2022

REALISATION OF TRINITARIAN CHARISM IN POLAND The publication presents the ways of realisation of Trinitarian charism in Poland on the basis of analysis of Church documents concerning charism and the basic elements of Trinitarian charism. The research also included source material on the history and symptoms of Trinitarian charism, including in particular documents testifying to the history and activity of Trinitarians in Poland. In the treatise, the following methods have been used: analytical, historical and comparative. Furthermore, the author’s considerations are divided into four chapters. In the first chapter, the notion of monastic life charism as well as the genesis and development of Trinitarian charism, especially in Polish lands, have been discussed. The next three chapters present two essential elements of Trinitarian charism, i.e. the worship of the Holy Trinity and the service of redemption and mercy, as well as the idea of a community based on equality and brotherhood, in which this charism is manifested. According to the accepted methodology, a starting point for these considerations included each time a reference to the teachings of the Church on a given subject, and later the discussion concerned the development of particular elements of Trinitarian charism over the centuries was presented. The forms of their realisation in Poland are discussed as well.
Coupling Theory and Advising Systems: A New Perspective for Advising Leadership
Authors: Kapinos Brian , Kyncl Rhonda Dean
Published: July 2022

Coupling is a concept used within education, business, and organizational management literature. Its application to organizational management literature allows researchers to understand how organizations function. This article argues that coupling theory can be applied to advising systems' technical (practice) and authoritative (coordination and supervision) aspects. Using coupling theory as a lens to view advising structures and as a language for communicating that assessment can provide profound lessons for more responsive and effective advising practices on college campuses. Additionally, coupling theory may broaden perspectives and deepen advising leaders' communicative vocabulary and allow them to become more skilled and effective administrators in applying these insights to higher education and their institutions.
What can healthcare managers learn from marketing managers? Marketing theory concepts with implications for healthcare
Authors: Voyer Benjamin G
Published: July 2022

Healthcare managers are increasingly relying on advances in management science to improve service organisation, operations and delivery, with the aim of better serving patients. Acknowledging the unique and specific nature of healthcare, and the associated constraints, this article argues that healthcare managers can learn from recent developments in the field of marketing in order to better understand and serve patients. Theories and concepts in the service marketing and consumer behaviour literature emphasise the need to take the perspective of consumers and co-construct meaningful experiences with them. In addition, marketing theories and concepts such as service-dominant logic, the ‘jobs-to-be-done’ approach and the duality of mind carry implications both in terms of understanding how to interact with patients and how to approach healthcare management in the modern world. Adopting these principles in healthcare management practices can result in a better understanding of the patient journey throughout their healthcare experience.
Cell and body tissue physiology
Authors: Elbourne Scott
Published: July 2022

This article discusses cell and tissue physiology and provides a basic review of their structure, function, and life cycle. Altered physiology is explored using clinical scenarios to give context to the aetiology of tumorigenesis.
Missed nursing care: a snapshot case study in a medical ward in Australia
Authors: Albsoul Rania Ali , FitzGerald Gerard , Alshyyab Muhammad Ahmed
Published: July 2022

Background:

Missed nursing care is a global issue in acute healthcare settings. It is a complex phenomenon that refers to nursing care that is required by patients but left undone or significantly delayed.

Aim:

To investigate the nature of missed nursing care and influencing factors in a general medical ward in an acute care hospital in Brisbane, Australia.

Method:

This is a descriptive case study. The study was carried out in a 29-bed inpatient general medical/cardiology/telemetry ward in an acute care tertiary hospital.

Results:

The study ward has been identified as a high complexity unit. The survey data found that the most frequent nursing care elements missed, as reported by the patients, were oral care, response to machine beep, and response to call light. The most frequent nurse-reported missed care items were ambulation, monitoring fluid intake/output and attendance at interdisciplinary conferences.

Conclusion:

Despite mandating nurse-to-patient ratios in the study ward, inadequate staffing was still perceived as being problematic and one of the most frequent reasons leading to missed nursing care. This possible disconnect between mandated staffing ratios and the persistence of perceived missed care suggests a more complex relationship than can be managed by macro (large-scale) resourcing formulas alone.
Patient safety, choice and the law: news round-up
Authors: Tingle John
Published: July 2022

John Tingle, Lecturer in Law, Birmingham Law School, University of Birmingham, discusses some reports on patient admission and discharge that have important patient safety and legal implications
A matter of taste: alteration in patients with cancer
Authors: Donald Mhairi
Published: July 2022

Taste alteration (dysgeusia) is a common nutritional impact symptom in people affected by cancer, as a result of either the cancer itself or its treatments. It can have a significant impact on oral intake and nutritional status. Taste alteration can also have a negative impact on food behaviours and quality of life. There is a paucity of evidence both on how the problem is assessed in patients and on strategies and guidelines to manage it. This article gives an overview of taste alterations in cancer, highlights recent reviews and summarises some key practical management themes.
A multidisciplinary approach to providing blended diet within the acute setting
Authors: Bremner Sarah , Brooks Michelle
Published: July 2022

Background:

Due to advances in medical care, including nutrition and hydration, children with neurological impairment are surviving longer. Many of these children are fed using a commercial formula via an enteral feeding tube. However, families are now becoming more interested in administering blended diet via their child's gastrostomy in a bid to reduce often significant gastrointestinal symptoms including reflux, constipation, gagging and retching post fundoplication.

Aims:

To describe the process undertaken by the authors' short-life working group to create safe, robust pathways to enable children to have access to blended diet while in the acute hospital setting.

Methods:

A multidisciplinary team short-life working group was established, which consisted of representatives from nursing, dietetics and catering. Following this a scoping exercise was undertaken to assess what practices were carried out in other health boards, prior to the creation of documentation.

Conclusion:

In conjunction with senior management and the Central Legal Office, the authors' short life working group has created safe, robust documentation and pathways to enable children in a large tertiary paediatric centre to access blended diet while in the acute setting. Due to the recent COVID-19 pandemic the pilot study to trial these documents within the neurology ward was delayed, however this work is ongoing. Furthermore, the authors will be looking to train nursing staff within ward areas to administer blended diet within the ward setting.
The complex nature of caries prevention
Authors: Matthew Charmaine
Published: July 2022

Charmaine Matthew discusses the factors which impact tooth decay.
Reflecting on the 2021 inaugural conference
Authors: Tait Sally , Dainton Marissa
Published: July 2022

Sally Tait and Marissa Dainton reflect upon the Association of Nephrology Nurses' inaugural conference, which included a wide range of talks and workshops from experts within renal care
Research roundup
Authors: Welyczko Nikki
Published: July 2022

In this section, Nikki Welyczko presents a brief synopsis of a range of recently published articles that may be of interest to nurses working in the renal setting. The aim of this roundup is to provide an overview, rather than a detailed summary and critique, of the research papers selected. Should you wish to look at any of the papers in more detail, a full reference is provided.
The home dialysis Special Interest Group
Authors: Williams Gail , Rhodes Carol , Thompson Laura
Published: July 2022

Gail Williams, Carol Rhodes and Laura Thompson provide an update on the home dialysis Special Interest Group
Nourishing the soul with food and keeping well in the depths of winter
Authors: Duval Deborah
Published: July 2022

Deborah Duval describes her experience of building a positive relationship with food
A national renal nursing course
Authors: Dainton Marissa
Published: July 2022

Marissa Dainton provides an update on the national renal nursing course that the Association of Nephrology Nurses has been working towards
Just the job: supporting kidney patients in employment matters
Authors: Docherty Liz
Published: July 2022

Liz Docherty details the issues that kidney patients often experience at work and provides some advice on how these can be overcome
‘I didn't have any option’: experiences of people receiving in-centre haemodialysis during the COVID-19 pandemic
Authors: Danton Ian , Kapadi Romaana , Elander James , Louth Charlotte , Selby Nicholas M , Taal Maarten W , Stalker Carol , Mitchell Kathryn
Published: July 2022

Background/Aims:

People receiving in-centre haemodialysis (ICHD) during the COVID-19 pandemic had to adjust to more challenging treatment conditions. This article aims to explore people's experiences of adjustment to ICHD during the pandemic.

Methods:

Thematic analysis of in-depth, semi-structured interviews with 14 adult UK ICHD patients.

Findings:

A total of four themes were identified: perceptions of the threat, impacts on treatment, impaired communication and coping and positive adjustment. These themes described participants' experiences of vulnerability to COVID-19; the ways the pandemic affected dialysis and clinical care; the impact that measures to reduce viral transmission had on communication and interaction within dialysis units; and ways that participants coped and made positive adjustments to the adversities imposed by the pandemic.

Conclusions:

The findings give insights into adjustment during extreme adversity. They also help to identify how support for ICHD patients could be improved as pandemic conditions recede and ways that dialysis units could prepare for future outbreaks of infectious illness.
Establishing peer support services for renal patients: a Welsh experience
Authors: Popham Joanne , O'Leary Catherine , Mikhail Ashraf
Published: July 2022

Patients with chronic kidney disease would benefit from peer support. The authors describe their experience in establishing the service in Wales. The essential requirements for establishing the service are explained. In addition to identifying suitable staffing, a structured and accredited training program for mentors is essential for the success and maintenance of the service. Formal training enables peer mentors to develop their listening skills, communicate effectively and clearly with mentees and identifies ways to deal with any challenging scenarios the mentor may face while providing their peer support. Policies to retain and reward mentors for their contribution are essential to sustain the service, develop the mentor's skills and expand the service that is not currently recognised or funded by healthcare providers. This article provides an outline of the process required to establish an active and long-term peer support programme, based on our local experience in south west Wales. The authors conclude by providing some quotes from their current mentors, describing how rewarding their involvement in the support process has been and summarising key elements needed to sustain an active peer support service and vision for future development.
Antimicrobial effects of bacterial binding to a dialkylcarbamoyl chloride-coated wound dressing: an in vitro study
Authors: Husmark Johanna , Morgner Bianka , Susilo Yusak Budi , Wiegand Cornelia
Published: July 2022

Objective:

Wound dressings that inactivate or sequestrate microorganisms, such as those with a hydrophobic, bacteria-binding dialkylcarbamoyl chloride (DACC) surface, can reduce the risk of clinical infections. This ‘passive’ bioburden control, avoiding bacterial cell wall disruption with associated release of bacterial endotoxins aggravating inflammation, is advantageous in hard-to-heal wounds. Hence, the full scope of DACC dressings, including the potential impact of higher inoculum densities, increased protein load and different pH on antibacterial activity, needs to be evaluated.

Method:

The Japanese Industrial Standard (JIS) L 1902 challenge test was used to evaluate the antimicrobial activity of the DACC-coated dressing against several World Health Organization (WHO)-prioritised wound pathogens (e.g., meticillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, microorganisms with extended-spectrum beta-lactamases and Acinetobacter baumannii), the effect of repeated bacterial challenge in an adverse wound environment, and antimicrobial performance at wound-related pH.

Results:

High antibacterial activity of the DACC-coated dressing against the WHO-prioritised bacteria strains by its irreversible binding and inhibition of growth of bound bacteria was confirmed using JIS L 1902. At increased inoculation densities, compared to standard conditions, the DACC-coated dressing still achieved strong-to-significant antibacterial effects. Augmenting the media protein content also affected antibacterial performance; a 0.5–1 log reduction in antibacterial activity was observed upon addition of 10% fetal calf serum. The pH did not influence antibacterial performance. The DACC-coated dressing also sustained antibacterial activity over subsequent reinfection steps.

Conclusion:

It can be assumed that the DACC-coated dressing exerts beneficial effects in controlling the wound bioburden, reducing the overall demand placed on antibiotics, without using antimicrobial substances.
Interprofessional learning within a non-medical prescribing module
Authors: McTaggart Gillian , Moore Kim
Published: July 2022

Multidisciplinary working/prescribing as part of a team is a key competence within the Royal Pharmaceutical Society (2021) prescribing competency framework. Interprofessional learning within an academic setting can improve multidisciplinary working within clinical practice. This article aims to demonstrate that Interprofessional learning can be successfully introduced into a non-medical prescribing module which has the potential to improve clinical practice. The authors outline the professional academic experiences of prescribers and make future recommendations. Discussion points included: interprofessional learning within an academic setting can improve multidisciplinary working within clinical practice, why multidisciplinary working is important to prescribing practice, how the benefit of Interprofessional within a non-medical prescribing module has not previously been explored, how Interprofessional can be introduced into a non-medical prescribing module and how benefits could be wide ranging. Interprofessional learning within a non-medical prescribing module is a useful approach with wide-ranging benefits, however, further research in this area is required.
The Effects of A-site Doping on Crystal Structure, Microstructure and Electrical Properties of (Ba0.85Ca0.15) Zr0.1Ti0.9O3 Ceramics
Authors:   Faculty of Science, Energy and Environment, King Mongkut’s University of Technology North Bangkok, Rayong Campus, Rayong 21120, Thailand, Jaiban Panupong ,   Research Center for Quantum Technology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand, Theethuan Thanakrit ,   Faculty of Science, Energy and Environment, King Mongkut’s University of Technology North Bangkok, Rayong Campus, Rayong 21120, Thailand,   Research Center for Quantum Technology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand, Khumtrong Saryrung ,   Faculty of Science, Energy and Environment, King Mongkut’s University of Technology North Bangkok, Rayong Campus, Rayong 21120, Thailand,   Research Center for Quantum Technology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand, Lokakaew Sirintra ,   Faculty of Science, Energy and Environment, King Mongkut’s University of Technology North Bangkok, Rayong Campus, Rayong 21120, Thailand,   Research Center for Quantum Technology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand, Kongchana Patharacha ,   Faculty of Science, Energy and Environment, King Mongkut’s University of Technology North Bangkok, Rayong Campus, Rayong 21120, Thailand,   Research Center for Quantum Technology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand, Watcharapasorn Anucha ,   Research Center for Quantum Technology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand,   Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand,   Center of Excellence in Materials Science and Technology, Materials Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
Published: July 2022

(Ba0.85Ca0.15) Zr0.1Ti0.9O3 (BCZT) ceramics with donor (La3+ and Bi3+ ions) and acceptor (Na+ ions) doping at the A-site were fabricated in this study. The effects of crystal structure, microstructure, and chemical defects on all samples’ dielectric properties and piezoelectric coeffi cient (d33) were observed. Bi3+ ions decreased grain size, decreased phase transition temperature, and caused the diffuse dielectric spectrum, resulting in a low d33 value. Na+ ions induced abnormal grain growth, leading to enhancement in maximum dielectric constant; meanwhile, the phase transition temperature increased. The d33 value of Na-doped BCZT was comparable with BCZT ceramic. The addition of La3+ ions increased the phase transition temperature and decreased grain size. The d33 value of La-doped BCZT was lower than BCZT ceramic. The result suggested that BCZT, BCZT-Na, and BCZT-La ceramics could be alternative materials for piezoelectric energy harvesting devices.
Meaningful values in the Short Form Health Survey-36 after total knee arthroplasty – an alternative to the EuroQol five-dimension index as a measure for health-related quality of life
Authors: Clement Nick D. , Weir David , Deehan David
Published: July 2022

Aims

To identify the responsiveness, minimal clinically important difference (MCID), minimal clinical important change (MIC), and patient-acceptable symptom state (PASS) thresholds in the 36-item Short Form Health Survey questionnaire (SF-36) (v2) for each of the eight dimensions and the total score following total knee arthroplasty (TKA).

Methods

There were 3,321 patients undergoing primary TKA with preoperative and one-year postoperative SF-36 scores. At one-year patients were asked how satisfied they were and “How much did the knee arthroplasty surgery improve the quality of your life?”, which was graded as: great, moderate, little (n = 277), none (n = 98), or worse.

Results

Physical function, role limitations due to physical problems (‘role physical’), bodily pain, and the total score SF-36 scores demonstrated the greatest effect sizes (> 0.9). The MCID for each of SF-36 dimensions ranged from 1.7 for role emotional to 6.4 for bodily pain. The MICs for a cohort of patients ranged from -1.0 for general health to 11.1 for bodily pain. The MICs for an individual patient were marginally greater (one to two points) compared to those for a cohort, and ranging from 0.0 for general and mental health to 13.5 for physical function. The lowest PASS score threshold was associated with physical function (> 34 points) whereas the greatest threshold (> 69 points) was associated with mental health.

Conclusion

The SF-36 is a responsive tool, and the estimates for MCID, MIC, and PASS thresholds that can be used to power studies, assess whether there has been a meaningful change in patients’ health-related quality of life, and can be used as a marker of achieving patient satisfaction following TKA. Cite this article: Bone Joint Res 2022;11(7):477–483.