bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review
Authors: Torre María F. , Martinez-Ferran María , Vallecillo Néstor , Jiménez Sergio L. , Romero-Morales Carlos , Pareja-Galeano Helios
Published: February 2021

Muscle damage induced by exercise may have several consequences such as delayed-onset muscle soreness, a side-effect of the release of free radicals during oxidative stress. To mitigate the oxidative stress cascade, the oral intake of antioxidants has been assessed by several research groups. This review examines whether supplementation with vitamin C and/or vitamin E is able to prevent or attenuate delayed-onset muscle soreness after eccentric exercise. The PubMed, Web of Science, Medline, and Embase databases were searched to identify studies meeting the inclusion criteria: primary randomized control trials, healthy male and female participants aged 16–80 years, and an intervention consisting of the intake of vitamin C and/or vitamin E without other supplements plus a controlled eccentric exercise regimen. Further requirements were the measurement of muscle soreness or markers of delayed-onset muscle soreness. All original full-text articles in English or translated into English published from January 2000 to June 2020 were considered for this review. Fourteen studies were finally identified, including 280 participants, 230 men, and 50 women aged 16–30 years. All participants were healthy individuals with different starting levels of physical activity. Supplementation was acute in two studies and chronic in 12, and its consisted of vitamin C in eight studies, vitamin E in two studies, and both in four studies. Only in 3 of the 14 studies was muscle soreness found to be significantly reduced in response to vitamin C and/or vitamin E supplementation at all time points when compared to the placebo group. Despite some studies showing the beneficial effects of chronic supplementation with these vitamins on muscle soreness manifesting 24–72 h after eccentric exercise, the evidence is so far insufficient to confirm that the intake of antioxidant vitamins is able to minimize delayed-onset muscle soreness in this context.
Protective Effect of Cocoa Bean Shell against Intestinal Damage: An Example of Byproduct Valorization
Authors: Rossin Daniela , Barbosa-Pereira Letricia , Iaia Noemi , Sottero Barbara , Danzero Alice Costanza , Poli Giuseppe , Zeppa Giuseppe , Biasi Fiorella
Published: February 2021

Background: Cocoa bean shell (CBS), a main byproduct of cocoa processing, represents a source of components such as polyphenols and methylxanthines, which have been associated with a reduced risk of several diseases. Therefore, CBS has potential application as a food ingredient. Intestinal mucosa is exposed to immune and inflammatory responses triggered by dietary agents, such as oxysterols, which derive from cholesterol oxidation and are pro-oxidant compounds able to affect intestinal function. We aimed at investigating the capability of the Forastero cultivar CBS, added or not added to ice cream, to protect against the intestinal barrier damage induced by a dietary oxysterol mixture. Methods: Composition and antioxidant capacity of in vitro digested CBS and CBS-enriched ice cream were analyzed by high-performance liquid chromatography and 1,1-diphenyl-2-picryl-hydrazyl radical-scavenging assay, respectively. CaCo-2 cells differentiated into enterocyte-like monolayer were incubated with 60 µM oxysterol mixture in the presence of CBS formulations. Results: The oxysterol mixture induced tight junction impairment, interleukin-8 and monocyte chemoattractant protein-1 cell release, and oxidative stress-related nuclear factor erythroid 2 p45-related factor 2 response Nrf2. Both CBSs protected cells from these adverse effects, probably thanks to their high phenolic content. CBS-enriched ice cream showed the highest antioxidant capacity. Theobromine, which is in high concentrations of CBS, was also tested. Although theobromine exerted no effect on Nrf2 expression, its anti-inflammatory cooperating activity in CBS effect cannot be excluded. Conclusions: Our findings suggest that CBS-enriched ice cream may be effective in the prevention of gut integrity damage associated with oxidative/inflammatory reactions.
The Application of an Impedance-Passivity Controller in Haptic Stability Analysis
Authors: Chen Ping-Nan , Chen Yung-Te , Hsiu Hsin , Chen Ruei-Jia
Published: February 2021

This paper proposes a passivity theorem on the basis of energy concepts to study the stability of force feedback in a virtual haptic system. An impedance-passivity controller (IPC) was designed from the two-port network perspective to improve the chief drawback of haptic systems, namely the considerable time required to reach stability if the equipment consumes energy slowly. The proposed IPC can be used to achieve stability through model parameter selection and to obtain control gain. In particular, haptic performance can be improved for extreme cases of high stiffness and negative damping. Furthermore, a virtual training system for one-degree-of-freedom sticking was developed to validate the experimental platform of our IPC. To ensure consistency in the experiment, we designed a specialized mechanical robot to replace human operation. Finally, compared with basic passivity control systems, our IPC could achieve stable control rapidly.
The Role of Biomarkers in Adrenocortical Carcinoma: A Review of Current Evidence and Future Perspectives
Authors: Mizdrak Maja , Tičinović Kurir Tina , Božić Joško
Published: February 2021

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy arising from the adrenal cortex often with unexpected biological behavior. It can occur at any age, with two peaks of incidence: in the first and between fifth and seventh decades of life. Although ACC are mostly hormonally active, precursors and metabolites, rather than end products of steroidogenesis are produced by dedifferentiated and immature malignant cells. Distinguishing the etiology of adrenal mass, between benign adenomas, which are quite frequent in general population, and malignant carcinomas with dismal prognosis is often unfeasible. Even after pathohistological analysis, diagnosis of adrenocortical carcinomas is not always straightforward and represents a great challenge for experienced and multidisciplinary expert teams. No single imaging method, hormonal work-up or immunohistochemical labelling can definitively prove the diagnosis of ACC. Over several decades’ great efforts have been made in finding novel reliable and available diagnostic and prognostic factors including steroid metabolome profiling or target gene identification. Despite these achievements, the 5-year mortality rate still accounts for approximately 75% to 90%, ACC is frequently diagnosed in advanced stages and therapeutic options are unfortunately limited. Therefore, imperative is to identify new biological markers that can predict patient prognosis and provide new therapeutic options.
Natural Progression of Non-Alcoholic Steatohepatitis to Hepatocellular Carcinoma
Authors: Ramai Daryl , Tai Waqqas , Rivera Michelle , Facciorusso Antonio , Tartaglia Nicola , Pacilli Mario , Ambrosi Antonio , Cotsoglou Christian , Sacco Rodolfo
Published: February 2021

Non-alcoholic steatohepatitis (NASH) is a chronic and progressive form of non-alcoholic fatty liver disease (NAFLD). Its global incidence is increasing which makes NASH an epidemic and a public health threat. Due to repeated insults to the liver, patients are at risk for developing hepatocellular carcinoma (HCC). The progression of NASH to HCC was initially defined according to a two-hit model which involved the development of steatosis, followed by lipid peroxidation and inflammation. However, current research defines a “multi-hit” or “multi-parallel hit” model which synthesizes several contributing pathways involved in progressive fibrosis and oncogenesis. This perspective considers the effects of cellular, genetic, immunologic, metabolic, and endocrine pathways leading up to HCC which underscores the complexity of this condition. This article will provide an updated review of the pathogenic mechanisms leading from NASH to HCC as well as an exploration of the role of biomarkers and screening.
The Determination of the Minimum Anaesthetic Concentration of Halothane in the Rock Dove (Columba livia) Using an Electrical Stimulus
Authors: Lehmann Heidi S. , Beausoleil Ngaio J. , Kongara Kavitha , Singh Preet M. , Chambers John Paul , Musk Gabrielle C. , Johnson Craig
Published: February 2021

This study aims to determine the minimum anaesthetic concentration (MAC) of halothane in the Rock Dove using electrical stimulus. Seven Rock Doves are anaesthetised with halothane, and the MAC is determined using the bracketing method. An electrical stimulus (two single pulses and two five-second stimuli, all separated by five-second pauses; 30 Hz, 30 V, 7.5 ms) is applied to the legs via subcutaneous electrodes. A maximum of eight periods of electrical stimulation, each with a preceding 15 min stable phase, is applied to each bird. If the non-reflexive movement occurred following stimulation, the end-tidal halothane (Fe’Hal) is increased by 10% before the next stimulus delivery. If no movement occurred, Fe’Hal is decreased by 10%. The MAC is the average of the highest concentration that allowed movement and the lowest that prevented movement. Physiological variables and ventilatory settings are recorded every five minutes. The current delivered is calculated offline. The mean ± SD MAC of halothane is 1.62 ± 0.29%, calculated from five birds. During the entire anaesthesia, all birds had cardiac arrhythmias —with three having sporadic recurrent periods of prolonged ventricular standstill followed by marked sinus tachycardia. The mean recorded voltage and calculated current and resistance are 27.6 ± 2.7 V, 20.3 ± 7.3 mAmp and 1.6 ± 0.9 kΩ, respectively. The advantage of halothane for prolonged anaesthesia in Rock Doves may be limited when noxious stimulation is used, due to the development of severe ventricular arrhythmias.
Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice
Authors: Crawford Kerryanne , Oliver Peter L. , Agnew Thomas , Hunn Benjamin H. M. , Ahel Ivan
Published: February 2021

Adenosine diphosphate ribosylation (ADP-ribosylation; ADPr), the addition of ADP-ribose moieties onto proteins and nucleic acids, is a highly conserved modification involved in a wide range of cellular functions, from viral defence, DNA damage response (DDR), metabolism, carcinogenesis and neurobiology. Here we study MACROD1 and MACROD2 (mono-ADP-ribosylhydrolases 1 and 2), two of the least well-understood ADPr-mono-hydrolases. MACROD1 has been reported to be largely localized to the mitochondria, while the MACROD2 genomic locus has been associated with various neurological conditions such as autism, attention deficit hyperactivity disorder (ADHD) and schizophrenia; yet the potential significance of disrupting these proteins in the context of mammalian behaviour is unknown. Therefore, here we analysed both Macrod1 and Macrod2 gene knockout (KO) mouse models in a battery of well-defined, spontaneous behavioural testing paradigms. Loss of Macrod1 resulted in a female-specific motor-coordination defect, whereas Macrod2 disruption was associated with hyperactivity that became more pronounced with age, in combination with a bradykinesia-like gait. These data reveal new insights into the importance of ADPr-mono-hydrolases in aspects of behaviour associated with both mitochondrial and neuropsychiatric disorders.
Maternal Tobacco and Alcohol Use in Relation to Child Malnutrition in Gauteng, South Africa: A Retrospective Analysis
Authors: Modjadji Perpetua , Pitso Mpinane
Published: February 2021

Tobacco and alcohol use among mothers is associated with numerous adverse consequences for affected offspring, including poor growth and development. This study determined the association between maternal tobacco and alcohol use, and malnutrition, among infants aged ≤ 12 months (n = 300), in selected health facilities situated in Gauteng, South Africa. Data on alcohol and tobacco use were collected using a validated questionnaire, in addition to mothers’ socio-demographic characteristics and obstetric history. Stunting (low height/length-for-age), underweight (low weight-for-age) and thinness (low body mass index-for-age) were calculated using z-scores based on the World Health Organization child growth standards. The association of tobacco and alcohol use with stunting, underweight and thinness was analysed using logistic regression analysis. The results showed a mean age of 29 years (24.0; 35.0) for mothers and 7.6 ± 3 months for infants, and over half of the mothers were unemployed (63%). Approximately 18.7% of mothers had used tobacco and 3% had used alcohol during pregnancy. The prevalence of current tobacco and alcohol use among mothers were estimated at 14.3% and 49.7%, respectively, and almost three-quarters (67.3%) of them were still breastfeeding during the study period. Stunting (55%) was the most prevalent malnutrition indicator among infants, while underweight was 41.7%, and thinness was 22%. Current tobacco use was associated with increased odds of being thin [OR = 2.40, 95% CI: 1.09–5.45), and after adjusting for confounders, current alcohol use was associated with the likelihood of being underweight [AOR = 1.96, 95% CI: 1.06–3.63] among infants. Future prospective cohort studies that examine growth patterns among infants who are exposed to maternal tobacco and alcohol use from the intrauterine life to infancy are necessary to inform, partly, the public health programmes, to reduce malnutrition among children.
Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review
Authors: Kappou Kalliopi , Ntougia Myrto , Kourtesi Aikaterini , Panagouli Eleni , Vlachopapadopoulou Elpis , Michalacos Stefanos , Gonidakis Fragiskos , Mastorakos Georgios , Psaltopoulou Theodora , Tsolia Maria , Bacopoulou Flora , Sergentanis Theodoros N. , Tsitsika Artemis
Published: February 2021

Background: Anorexia nervosa (AN) is a serious, multifactorial mental disorder affecting predominantly young females. This systematic review examines neuroimaging findings in adolescents and young adults up to 24 years old, in order to explore alterations associated with disease pathophysiology. Methods: Eligible studies on structural and functional brain neuroimaging were sought systematically in PubMed, CENTRAL and EMBASE databases up to 5 October 2020. Results: Thirty-three studies were included, investigating a total of 587 patients with a current diagnosis of AN and 663 healthy controls (HC). Global and regional grey matter (GM) volume reduction as well as white matter (WM) microstructure alterations were detected. The mainly affected regions were the prefrontal, parietal and temporal cortex, hippocampus, amygdala, insula, thalamus and cerebellum as well as various WM tracts such as corona radiata and superior longitudinal fasciculus (SLF). Regarding functional imaging, alterations were pointed out in large-scale brain networks, such as default mode network (DMN), executive control network (ECN) and salience network (SN). Most findings appear to reverse after weight restoration. Specific limitations of neuroimaging studies in still developing individuals are also discussed. Conclusions: Structural and functional alterations are present in the early course of the disease, most of them being partially or totally reversible. Nonetheless, neuroimaging findings have been open to many biological interpretations. Thus, more studies are needed to clarify their clinical significance.
Intensity Modulated and Three-Dimensional Conformal Radiation Therapy Plans for Oropharyngeal Cancer: A Comparison of Their Sensitivity to Set-Up Errors and Uncertainties
Authors: Ploquin N. , Lau H. , Dunscombe P.
Published: February 2021

We compared the effect of set-up error and uncertainty on two radiation therapy treatment plans for head and neck cancer: one using intensity modulated radiation therapy (IMRT) and one using conventional three-dimensional conformal radiation therapy (3D-CRT). We used a Pinnacle3 (Philips Medical Systems, Markham, Ontario) system to create the two treatment plans (7-beam IMRT and 5-beam 3D-CRT) for the same volumetric data set, based on the objectives and constraints defined in the Radiation Therapy Oncology Group H-0022 protocol. In both plans, the dose–volume constraints for the targets and the organs at risk (OARS) were met as closely as the beam geometries would allow. Monte Carlo–based simulations of set-up error and uncertainty were performed in three orthogonal directions for 840 simulated “courses of treatment” for each plan. A systematic error (chosen from distributions characterized by standard deviations ranging from 0 mm to 6 mm) and random uncertainties (2 mm standard deviation) were incorporated. We used a probability approach to compare the sensitivities of the IMRT and the 3D-CRT plans to set-up error and uncertainty in terms of equivalent uniform dose (EUD) to targets and OARS. Based on the EUD analysis, the targets and OARS showed considerably greater sensitivity to set-up error with the IMRT plan than with the 3D-CRT plan. For the IMRT plan, target EUDS were reduced by 4%, 7.5%, and 10% for 2-mm, 4-mm, and 6-mm set-up errors respectively. However, even with set-up error, the mandible, spinal cord, and parotid EUDS always remained lower with the IMRT plan than with the 3D-CRT plan. We conclude that, when quantified by EUD, IMRT plan doses to OARS and targets are more sensitive to set-up error than are 3D-CRT-plan doses. However, as judged by the differences between target and OAR doses, IMRT retains its superiority over 3D-CRT, even in the presence of set-up error.
Impact of Geometric Uncertainties on Dose Distribution During Intensity Modulated Radiotherapy of Head-and-neck Cancer: The Need for a Planning Target Volume and A Planning Organ-at-Risk Volume
Authors: Ballivy O. , Parker W. , Vuong T. , Shenouda G. , Patrocinio H.
Published: February 2021

We assessed the effect of geometric uncertainties on target coverage and on dose to the organs at risk (OARS) during intensity-modulated radiotherapy (IMRT) for head-and-neck cancer, and we estimated the required margins for the planning target volume (PTV) and the planning organ-at-risk volume (PRV). For eight headand- neck cancer patients, we generated IMRT plans with localization uncertainty margins of 0 mm, 2.5 mm, and 5.0 mm. The beam intensities were then applied on repeat computed tomography (CT) scans obtained weekly during treatment, and dose distributions were recalculated. The dose–volume histogram analysis for the repeat CT scans showed that target coverage was adequate (V100 ≥ 95%) for only 12.5% of the gross tumour volumes, 54.3% of the upper-neck clinical target volumes (CTVS), and 27.4% of the lower-neck CTVS when no margins were added for PTV. The use of 2.5-mm and 5.0-mm margins significantly improved target coverage, but the mean dose to the contralateral parotid increased from 25.9 Gy to 29.2 Gy. Maximum dose to the spinal cord was above limit in 57.7%, 34.6%, and 15.4% of cases when 0-mm, 2.5-mm, and 5.0-mm margins (respectively) were used for PRV. Significant deviations from the prescribed dose can occur during IMRT treatment delivery for headand- neck cancer. The use of 2.5-mm to 5.0-mm margins for PTV and PRV greatly reduces the risk of underdosing targets and of overdosing the spinal cord.
The Role of Entropy in Construct Specification Equations (CSE) to Improve the Validity of Memory Tests
Authors: Melin Jeanette , Cano Stefan , Pendrill Leslie
Published: February 2021

Commonly used rating scales and tests have been found lacking reliability and validity, for example in neurodegenerative diseases studies, owing to not making recourse to the inherent ordinality of human responses, nor acknowledging the separability of person ability and item difficulty parameters according to the well-known Rasch model. Here, we adopt an information theory approach, particularly extending deployment of the classic Brillouin entropy expression when explaining the difficulty of recalling non-verbal sequences in memory tests (i.e., Corsi Block Test and Digit Span Test): a more ordered task, of less entropy, will generally be easier to perform. Construct specification equations (CSEs) as a part of a methodological development, with entropy-based variables dominating, are found experimentally to explain (r=R2 = 0.98) and predict the construct of task difficulty for short-term memory tests using data from the NeuroMET (n = 88) and Gothenburg MCI (n = 257) studies. We propose entropy-based equivalence criteria, whereby different tasks (in the form of items) from different tests can be combined, enabling new memory tests to be formed by choosing a bespoke selection of items, leading to more efficient testing, improved reliability (reduced uncertainties) and validity. This provides opportunities for more practical and accurate measurement in clinical practice, research and trials.
Computational Abstraction
Authors: Turner Raymond
Published: February 2021

Representation and abstraction are two of the fundamental concepts of computer science. Together they enable “high-level” programming: without abstraction programming would be tied to machine code; without a machine representation, it would be a pure mathematical exercise. Representation begins with an abstract structure and seeks to find a more concrete one. Abstraction does the reverse: it starts with concrete structures and abstracts away. While formal accounts of representation are easy to find, abstraction is a different matter. In this paper, we provide an analysis of data abstraction based upon some contemporary work in the philosophy of mathematics. The paper contains a mathematical account of how Frege’s approach to abstraction may be interpreted, modified, extended and imported into type theory. We argue that representation and abstraction, while mathematical siblings, are philosophically quite different. A case of special interest concerns the abstract/physical interface which houses both the physical representation of abstract structures and the abstraction of physical systems.
The Entropy Universe
Authors: Ribeiro Maria , Henriques Teresa , Castro Luísa , Souto André , Antunes Luís , Costa-Santos Cristina , Teixeira Andreia
Published: February 2021

About 160 years ago, the concept of entropy was introduced in thermodynamics by Rudolf Clausius. Since then, it has been continually extended, interpreted, and applied by researchers in many scientific fields, such as general physics, information theory, chaos theory, data mining, and mathematical linguistics. This paper presents The Entropy Universe, which aims to review the many variants of entropies applied to time-series. The purpose is to answer research questions such as: How did each entropy emerge? What is the mathematical definition of each variant of entropy? How are entropies related to each other? What are the most applied scientific fields for each entropy? We describe in-depth the relationship between the most applied entropies in time-series for different scientific fields, establishing bases for researchers to properly choose the variant of entropy most suitable for their data. The number of citations over the past sixteen years of each paper proposing a new entropy was also accessed. The Shannon/differential, the Tsallis, the sample, the permutation, and the approximate entropies were the most cited ones. Based on the ten research areas with the most significant number of records obtained in the Web of Science and Scopus, the areas in which the entropies are more applied are computer science, physics, mathematics, and engineering. The universe of entropies is growing each day, either due to the introducing new variants either due to novel applications. Knowing each entropy’s strengths and of limitations is essential to ensure the proper improvement of this research field.
Computational Complexity Reduction of Neural Networks of Brain Tumor Image Segmentation by Introducing Fermi–Dirac Correction Functions
Authors: Tai Yen-Ling , Huang Shin-Jhe , Chen Chien-Chang , Lu Henry Horng-Shing
Published: February 2021

Nowadays, deep learning methods with high structural complexity and flexibility inevitably lean on the computational capability of the hardware. A platform with high-performance GPUs and large amounts of memory could support neural networks having large numbers of layers and kernels. However, naively pursuing high-cost hardware would probably drag the technical development of deep learning methods. In the article, we thus establish a new preprocessing method to reduce the computational complexity of the neural networks. Inspired by the band theory of solids in physics, we map the image space into a noninteraction physical system isomorphically and then treat image voxels as particle-like clusters. Then, we reconstruct the Fermi–Dirac distribution to be a correction function for the normalization of the voxel intensity and as a filter of insignificant cluster components. The filtered clusters at the circumstance can delineate the morphological heterogeneity of the image voxels. We used the BraTS 2019 datasets and the dimensional fusion U-net for the algorithmic validation, and the proposed Fermi–Dirac correction function exhibited comparable performance to other employed preprocessing methods. By comparing to the conventional z-score normalization function and the Gamma correction function, the proposed algorithm can save at least 38% of computational time cost under a low-cost hardware architecture. Even though the correction function of global histogram equalization has the lowest computational time among the employed correction functions, the proposed Fermi–Dirac correction function exhibits better capabilities of image augmentation and segmentation.
Locally Adapted and Organically Grown Landrace and Ancient Spring Cereals—A Unique Source of Minerals in the Human Diet
Authors: Johansson Eva , Prieto-Linde Maria Luisa , Larsson Hans
Published: February 2021

Consumer interest in local and organic produce, sustainability along the production chain and food products contributing to health, are laying the foundation for local and organic-based diets using nutrient-dense food. Here, we evaluated 25 locally adapted landrace and ancient spring cereal genotypes per location over four locations and three years, for mineral content, nutritional yield and nutrient density. The results showed a large variation in minerals content and composition in the genotypes, but also over cultivation locations, cultivation years and for genotype groups. Highest minerals content was found in oats, while highest content of Zn and Fe was found in ancient wheats. The wheat Diamant brun, the wheat landrace Öland and naked barley showed high mineral values and high content of Zn and Fe when grown in Alnarp. Nutritional yield, of the cereals evaluated here, was high related to values reported internationally but lower than those found in a comparable winter wheat material. The nutrient density was generally high; less than 350 g was needed if any of the evaluated genotype groups were to be used in the daily diet to reach the recommended value of Zn and Fe, while if the suggested Novel Nordic Diet mix was used, only 250 g were needed. A transfer from currently consumed cereals to those in the present study, along the New Nordic Diet path, showed their potential to contribute as sustainable and nutrient-rich sources in the human diet.
Nondestructive Detection of the Gel State of Preserved Eggs Based on Dielectric Impedance
Authors: Li Cheng-Han , Hsieh Chun-Hung , Hung Cheng-Chu , Cheng Ching-Wei
Published: February 2021

After completing the production of preserved eggs, traditionally, the degree of gelling is judged by allowing workers to tap the preserved eggs with their fingers and sense the resulting oscillations. The amount of oscillation is used for the quality classification. This traditional method produces varying results owing to the differences in the sensitivity of the individual workers, who are not objective. In this study, dielectric detection technology was used to classify the preserved eggs nondestructively. The impedance in the frequency range of 2–300 kHz was resolved into resistance and reactance, and was plotted on a Nyquist diagram. Next, the diagram curve was fitted in order to obtain the equivalent circuit, and the difference in the compositions of the equivalent circuits corresponding to gelled and non-gelled preserved eggs was analyzed. A preserved egg can be considered an RLC series circuit, and its decay rate is consistent with the decay rate given by mechanical vibration theory. The Nyquist diagrams for the resistance and reactance of preserved eggs clearly showed that the resistance and reactance of gelled and non-gelled eggs were quite different, and the classification of the eggs was performed using Bayesian network (BN). The results showed that a BN classifier with two variables, i.e., resistance and reactance, can be used to classify preserved eggs as gelled or non-gelled, with an accuracy of 81.0% and a kappa value of 0.62. Thus, a BN classifier based on resistance and reactance demonstrates the ability to classify the quality of preserved egg gel. This research provides a nondestructive method for the inspection of the quality of preserved egg gel, and provides a theoretical basis for the development of an automated preserved egg inspection system that can be used as the scientific basis for the determination of the quality of preserved eggs.
The Impact of Optical Berry Sorting on Red Wine Composition and Sensory Properties
Authors: Bruce Robert C. , Lestringant Pauline , Brenneman Charles A. , Heymann Hildegarde , Oberholster Anita
Published: February 2021

The impact of optical berry sorting was investigated using Grenache, Barbera, and Cabernet Sauvignon grapes from Yolo County, California in 2016. Optical sorting parameters were adjusted to remove underripe berries and material other than grapes using color parameters. Wines were made from three treatments, control (no sorting), sort (accepted material), and reject (material rejected by the optical sorter). The rate of rejection was approximately 14.9%, 3.9%, and 1.5% (w/w) for Grenache, Barbera, and Cabernet Sauvignon, respectively. Chemical composition in the finished wines was analyzed by the Adams-Harbertson assay and reversed-phase high-performance liquid chromatography for phenolics, and head-space solid-phase microextraction gas chromatography mass spectrometry for aroma profiling. In general, optical sorting was successful in removing underripe berries and material other than grapes as evidenced by lower ethanol levels and higher concentrations of total phenolics and tannin (due to the inclusion of material other than grapes) in wine made from rejected material. Despite this, no difference in final ethanol content and minimal differences in phenolic composition were observed between control and sort treatment wines for the three varieties studied. Differences were observed in the aroma profiles of the reject treatments for all three varieties compared to sort and control; however, few compounds differed significantly between the sort and control treatments. Descriptive sensory analysis revealed that panelists had difficulty distinguishing aroma, taste, mouthfeel, and color parameters among wines made from different treatments for all three varieties. Thus, optical sorting had minimal impact on wine sensory properties using the varieties and vineyards studied. Optical sorting may be used to differentiate and sort for different ripeness levels using color as a primary criterion; however, the impact on the resulting wine is likely dependent on the initial variability in grape ripeness.
Dynamics of the Degradation of Acetyl-CoA Carboxylase Herbicides in Vegetables
Authors: Jursík Miroslav , Hamouzová Kateřina , Hajšlová Jana
Published: February 2021

(1) Background: Aryloxyphenoxy-propionates and cyclohexanediones are herbicides most widely used in dicot crops worldwide. The main objective of the study was to determine the dynamics of herbicide residues in carrot, lettuce, cauliflower, and onion in order to suggest a low level of residues in harvested vegetables. (2) Methods: Small plot field trials were carried out in four vegetables in the Czech Republic. The samples of vegetables were collected continuously during the growing season. Multiresidue methods for the determination of herbicide residues by LC-MS/MS were used. Non-linear models of degradation of individual herbicides in vegetables were calculated using the exponential decay formula. Action GAP pre-harvest intervals for the 25% and 50% maximum residue limit (MRL) and 10 µg kg−1 limit (baby food) were established for all tested herbicides. (3) Results: The degradation dynamics of fluazifop in carrot, onion, and cauliflower was significantly slower compared to quizalofop and haloxyfop. The highest amount (2796 µg kg−1) of fluazifop residues was detected in cauliflower 11 days after application. No residue of propaquizafop and cycloxydim was detected in any vegetable samples. (4) Conclusions: Aryloxyphenoxy-propionate herbicide (except propaquizafop) could contaminate vegetables easily, especially vegetables with a short growing season. Vegetables treated with fluazifop are not suitable for baby food. Lettuce and cauliflower treated by quizalofop are not suitable for baby food, but in onion and carrot, quizalofop could be used. Propaquizafop and cycloxydim are prospective herbicides for non-residual (baby food) vegetable production.
Developing an Integrated Caregiver Patient-Portal System
Authors: Longacre Margaret L. , Keleher Cynthia , Chwistek Marcin , Odelberg Michelle , Siemon Mark , Collins Molly , Fang Carolyn Y.
Published: February 2021

We have developed an integrated caregiver patient-portal system (i.e., patient–caregiver portal) that (1) allows a patient to identify their primary caregiver and their communication preferences with that caregiver in the healthcare setting; (2) connects the caregiver to a unique portal page to indicate their needs; and (3) informs the healthcare team of patient and caregiver responses to aid in integrating the caregiver. The purpose of this manuscript is to report on the formative phases (Phases I and II) of system development. Phase I involved a pre-assessment to anticipate complexity or barriers in the system design and future implementation. We used the non-adaption, abandonment, scale-up, spread, and sustainability (NASSS) framework and rubric to conduct this pre-assessment. Phase II involved exploring reactions (i.e., concerns or benefits) to the system among a small sample of stakeholders (i.e., 5 palliative oncology patients and their caregivers, N = 10). The purpose of these two phases was to identify system changes prior to conducting usability testing among patient/caregiver dyads in palliative oncology (phase III). Completion of the NASSS rubric highlighted potential implementation barriers, such as the non-uniformity of caregiving, disparities in portal use, and a lack of cost–benefit (value) findings in the literature. The dyads’ feedback reinforced several NASSS ratings, including the benefits of connecting caregivers and allowing for caregiver voice as well as the concerns of limited use of patient-portals by the patients (but not the caregivers) and the need for user assistance during stressful health events. One change that resulted from this analysis was ensuring that we provided research participants (users) with detailed guidance and support on how to log in and use a patient–caregiver portal. In future iterations, we will also consider allowing more than one caregiver to be included and incorporating additional strategies to enable caregivers to interact in the system as part of the care team (e.g., via email).
Does Employee Care Trigger Innovation Under a Healthy and Safe Working Environment? Evidence from the Pharmaceutical Industry in China
Authors: Yang Minghui , Lin Qian , Maresova Petra
Published: February 2021

Sustainability of the workforce becomes a crucial issue, of which responsible care for employees can increase job satisfaction and human capital that impact corporate ability to absorb and generate new knowledge. Firms are obligated to provide a healthy and safe working environment for their employees, but it may in turn hinder innovation due to rigid and structured institutional regulations. Drawing on data of 308 China’s pharmaceutical firms from 2010 to 2017, we investigated whether employee care can trigger innovation under corporate adoption of the occupational health and safety management system (OHSMS). Our results suggest that both employee care and OHSMS adoption have a positive impact on innovation. Moreover, the positive relationship between employee care and innovation was more pronounced in firms that had adopted the OHSMS certification. These findings are valuable to policymakers and corporate managers in emerging economies through corroborating the important role of workforce sustainability in facilitating firm innovation.
Panic and Trust during COVID-19: A Cross-Sectional Study on Immigrants in South Korea
Authors: Yoon Myeong Sook , Feyissa Israel Fisseha , Suk So-Won
Published: February 2021

In the COVID-19 pandemic, marginalized groups like migrants are disproportionately affected. As panic, fear of neglect, and mistrusting institutions in these groups are presumed to be apparent, their detachment to health services still needs to be investigated. This study comparatively analyzed the level of panic and trust between South Koreans and immigrants who are living within highly affected areas of South Korea. Mann–Whitney-U-Test and Pearson correlation showed panic is more pronounced in the Korean group while having a similar panic display pattern with the immigrants. The immigrant group appears to highly trust the Korean health system, health institutions, local media, and the local native community. Beyond conventional expectations, participant’s average panic score showed a statistically significant positive correlation with items of the trust scale, indicating a level of individual reliance amid the pandemic panic. Thus, ascertaining institutional trust and matured citizenry are identified as factors for effective public health outcomes. During such a pandemic, this study also reminded the public health needs of immigrants as secondary citizens, and presumptions of immigrants’ mistrust in such settings might not always be true.
On the Transmission Dynamics of SARS-CoV-2 in a Temperate Climate
Authors: Kioutsioukis Ioannis , Stilianakis Nikolaos I.
Published: February 2021

An epidemiological model, which describes the transmission dynamics of SARS-CoV-2 under specific consideration of the incubation period including the population with subclinical infections and being infective is presented. The COVID-19 epidemic in Greece was explored through a Monte Carlo uncertainty analysis framework, and the optimal values for the parameters that determined the transmission dynamics could be obtained before, during, and after the interventions to control the epidemic. The dynamic change of the fraction of asymptomatic individuals was shown. The analysis of the modelling results at the intra-annual climatic scale allowed for in depth investigation of the transmission dynamics of SARS-CoV-2 and the significance and relative importance of the model parameters. Moreover, the analysis at this scale incorporated the exploration of the forecast horizon and its variability. Three discrete peaks were found in the transmission rates throughout the investigated period (15 February–15 December 2020). Two of them corresponded to the timing of the spring and autumn epidemic waves while the third one occurred in mid-summer, implying that relaxation of social distancing and increased mobility may have a strong effect on rekindling the epidemic dynamics offsetting positive effects from factors such as decreased household crowding and increased environmental ultraviolet radiation. In addition, the epidemiological state was found to constitute a significant indicator of the forecast reliability horizon, spanning from as low as few days to more than four weeks. Embedding the model in an ensemble framework may extend the predictability horizon. Therefore, it may contribute to the accuracy of health risk assessment and inform public health decision making of more efficient control measures.
Do the Green Credit Guidelines Affect Corporate Green Technology Innovation? Empirical Research from China
Authors: Hong Min , Li Zhenghui , Drakeford Benjamin
Published: February 2021

Green technology innovation is regarded as an important means to achieve sustainable development. Countries all over the world mainly implement green technology innovation policies from the aspects of environmental regulation and financing constraints. The effect of financing constraint policy on enterprise green technology innovation remains to be investigated. Based on the event of “green credit guidelines” issued by China Banking Regulatory Commission in 2012, this paper collects the panel data of China’s 2825 listed companies from 2007 to 2018, constructs a difference-in-difference model, and studies the impact of green credit guidelines on corporate green technology innovation and its mechanism. The empirical results show: First, green credit guidelines can promote corporate green technology innovation on the whole. Second, the mechanism of green credit on enterprise green technology innovation is identified. Green credit guidelines mainly limited green technology innovation through reducing debt financing, rather than through financing constraints. Third, the impact of green credit guidelines on green technology innovation is heterogeneous. Green credit guidelines have a significant effect on the green technology innovation of state-owned and large enterprises, but have no effect on the green technology innovation of non-state-owned and small ones.
How Did Italian Adolescents with Disability and Parents Deal with the COVID-19 Emergency?
Authors: Faccioli Silvia , Lombardi Francesco , Bellini Pierantonio , Costi Stefania , Sassi Silvia , Pesci Maria Cristina
Published: February 2021

The COVID-19 emergency has imposed distanced education and has interrupted most rehabilitation services. Adolescents with disabilities have been isolated, and the burden on their families has been exacerbated. A cross-sectional survey was administered to adolescents with disability and to parents of disabled children to describe their experience during lockdown and their concerns or expectations about rehabilitation. A sample of 53 adolescents and 239 parents completed the survey. Adolescents were ages 13–18 years old (45.3% female). Most parents were between 35 and 55 years old (84.9% female). While 53.6% of the parents reported no positive effects of the lockdown, 92.5% of the adolescents expressed favorable consequences. The increased time spent with family members was judged positively by 27.2% of parents and by 64.2% of adolescents. Concern for their child’s disability was expressed by 47.3% of parents, while 73.6% of adolescents expressed concerns regarding the ban on meeting friends. In both groups, anxiety symptoms were correlated with the fear of contracting COVID-19 and with financial problems. Parents would have liked even more remote support from school and healthcare professionals, which was available for most participants. Thus, socioeconomic support, assistive technology and telerehabilitation strategies might help families with disabilities during a lockdown.
Psychosocial Characteristics by Weight Loss and Engagement in a Digital Intervention Supporting Self-Management of Weight
Authors: Mitchell Ellen S. , Yang Qiuchen , Behr Heather , Ho Annabell , DeLuca Laura , May Christine N. , Michaelides Andreas
Published: February 2021

There is substantial variability in weight loss outcomes. Psychosocial characteristics underlying outcomes require better understanding, particularly on self-managed digital programs. This cross-sectional study examines differences in psychosocial characteristics by weight loss and engagement outcome, and which characteristics are most associated with weight loss, on a self-managed digital weight loss program. Some underexplored psychosocial characteristics are included, such as flourishing, or a sense of meaning and purpose in life. A questionnaire was emailed to a random sample of 10,000 current users at week 5 in the program and 10,000 current users at week 17. The questionnaire was completed by 2225 users, and their self-reported weight and recorded program engagement data were extracted from the program’s database. Multiple comparison tests indicated that mental health quality of life, depression, anxiety, work-life balance, and flourishing differed by weight loss outcome at program end (week 17; ≥5%, 2–5%, below 2%) and by engagement tertile at program beginning and end (weeks 5 and 17). Only anxiety was associated with weight loss in a backward stepwise regression controlling for engagement and sociodemographic characteristics. Flourishing did not predict weight loss overall but predicted the weight loss outcome group. Our findings have implications for creating more effective interventions for individuals based on psychosocial characteristics and highlight the potential importance of anxiety in underexplored self-managed digital programs.
Association Between PM2.5 Exposure Level and Primary Open-Angle Glaucoma in Taiwanese Adults: A Nested Case–control Study
Authors: Sun Han-Yin , Luo Ci-Wen , Chiang Yun-Wei , Li Kun-Lin Yeh Yi-Ching , Ho Yung-Chung , Lee Shiuan-Shinn , Chen Wen-Ying , Chen Chun-Jung , Kuan Yu-Hsiang
Published: February 2021

Primary open-angle glaucoma (POAG) is the most common type of glaucoma. However, little is known about POAG in adults and exposure to air pollution. The current study aims to investigate whether exposure to particulate matter with a mass median aerodynamic diameter of ≤2.5 μm (PM2.5) is associated with POAG diagnosis. Patient data were obtained from the Longitudinal Health Insurance Database 2010 (LHID2010) of Taiwan for the 2008–2013 period. PM2.5 concentration data, collected from the Ambient Air Quality Monitoring Network established by the Environmental Protection Administration of Taiwan, were categorized into four groups according to World Health Organization (WHO) exposure standards for PM2.5. We estimated the odds ratios (ORs) and 95% CIs for risk factors for POAG with logistic regression. The OR of per WHO standard level increase was 1.193 (95% CI 1.050–1.356). Compared with the normal level, the OR of WHO 2.0 level was 1.668 (95% CI 1.045–2.663, P < 0.05). After excluding confounding risk factors for POAG in this study, we determined that increased PM2.5 exposure is related to POAG risk (ORs > 1, P < 0.05). In this study, PM2.5 was an independent factor associated with open-angle glaucoma. Further research is required to better understand the mechanisms connecting PM2.5 and open-angle glaucoma.