bluuebunny/crossref_metadata_2025 huggingface dataset:
Can local agroforestry systems survive for rural development and sustainable ecosystems in dryland areas? A case study in Timorese Mamar systems
Authors: Moata M R S , Rosario P , Berg T V D , Sinlae D V , Rua Ora Y A N , Wardhana L D W , Takalapeta A , Benu Y
Published: February 2022

Mamar is a traditional agroforestry system established many years ago on Timor Island. It can maintain water reservoirs, natural habitat, and ecology conservation to support the livelihoods of local people. Although, Mamar is a symbol of heritage, “people will not leave it, but also do not want to see it” an unmanaged system. This study aims to understand the challenges and potential developments of the Mamar. A study on ecosystem services and the potential sustainability of Mamar was conducted in Ponain village using four sampling locations. Data was collected from observation, focus group discussion, laboratory analysis, and secondary data. The results showed that the change of land use from agroforestry to monoculture had reduced the quality of topsoil, water, and the biodiversity of local plants. Mamar could provide good services for the ecosystem, but we are unsure if it can be sustained because the youth tend to leave the Mamar. However, it seems likely this heritage can survive with strong partnership from Pentahelix collaboration (government, education, business, community, and media), applying multifunctional ecosystem (Agro ecotourism and community-based tourism), and eventually creating a business model. This collaboration will help to improve ecosystem and economic services, as well as rural development.
Potential of sago products supporting local food security in South Sulawesi
Authors: Dewayani W , Suryani  , Arum R H , Septianti E
Published: February 2022

Indonesia still relies on rice as a staple food, while at this time to meet the people’s needs for rice, the government still has to import it. Sago is one of the local foods that can meet the needs of the community as a food. This review aims to gather information on the current status of sago production in South Sulawesi, including the advantages and disadvantages of sago as a staple and the type of food technology required to produce the staple food. The advantage of sago compared to other carbohydrate sources is that the sago plant or sago forest is ready to be harvested if desired. Sago can be used for food or non-food purposes. One of the uses of sago for food is sago flour, starch, and various processed food products.

Meanwhile, for non-food needs, sago can be used as bioethanol and single-cell protein. Sago has disadvantages as a staple food due to lacking other nutrients such as protein and fat. Thus, in sago processing, the addition of other ingredients must be considered to meet these deficiencies.
Evaluation of azodicarbonamide (ADC) on density, expansion ratio and closed cell properties of natural rubber foam
Authors: Hanifarianty S , I Fathurrohman M.
Published: February 2022

Natural rubber foams were made with a one-step foaming process, the effect of density, expansion ratio, and closed-cell properties via microscope were investigated. This research aims to investigate novel half vulcanization and full vulcanization process with three various blowing agents by compression moulding to fabricate natural rubber and carbon black foams. Closed cells of natural rubber used as shoe soles were formed by azodicarbonamide (ADC) and organic blowing agents. The experimental design used three blowing agent of Azodicarbonamide (ADC) A, B C, and control. The data analysis for images was performed in ImageJ software to get more quantitative results. Experimental data were created to perform a full (AF; BF; and CF) and half vulcanization (AH; BH; and CH) process. The different structure model based on digital microscope images was shown. The AH, BH, and CH with half vulcanisation process revealed a higher expansion ratio and cell number value. The microscope showed that rubber foam with the highest expansion ratio and cell number has a more homogenous structure with more cell connection of AH, causing a lower density value of 0.6480. In addition, AH and CH with ADC showed higher values than BH with an organic blowing agent, respectively.
Local-adapted and high-yield varieties for sustainable Robusta coffee farming: Evidence from South Sumatera, Indonesia
Authors: Hasibuan A M , Randriani E , Wicaksono I N A , Dani  , Santoso T J
Published: February 2022

Climate change causes an adverse impact on the coffee plantation as it directly influences the productivity and quality of coffee products. For the adaptation strategy, using superior variety is often considered an important step because it has potential attributes such as high yield and quality, and is more tolerant to certain environmental shocks. This study aims to analyze the environmental adaptability and financial feasibility of local Robusta coffee varieties. This study used data from field observations, surveys, and interviews of key informants in Ogan Komering Ulu Regency, South Sumatera, Indonesia from 2018-2021. Data were analyzed descriptively. Results showed that three local clones have high adaptability in the study site, even in a high precipitation rate. The varieties are financially feasible to be adopted by farmers, even though on a small scale. Sensitivity analysis with the scenario of decreasing the yield or increasing operational cost as the impact of climate variability about 10 percent showed the lower feasibility indicators (NPV, IRR, and Net B/C), but still higher than the minimum threshold so that still feasible and profitable for farmers. Hence, the three local clones are the potential to be developed for sustainable Robusta coffee plantations.
Some coefficient estimates on real kernel 𝛼-harmonic mappings
Authors: Long Bo-Yong , Wang Qi-Han
Published: February 2022

We call the solution of a kind of second order homogeneous partial differential equation as real kernel

α
−

\alpha -

harmonic mappings. For this class of mappings, we explore its Heinz type inequality. Furthermore, for a subclass of real kernel

α
−

\alpha -

harmonic mappings with real coefficients, we estimate their coefficients. At last, we study the extremal function of Schwartz type lemma for the class of real kernel

α
−

\alpha -

harmonic mappings.
Bilinear maximal functions associated with surfaces
Authors: Chen Jiecheng , Grafakos Loukas , He Danqing , Honzík Petr , Slavíková Lenka
Published: February 2022

We obtain

L
2

×

L
2

→

L
1

L^2\times L^2\to L^1

boundedness for bilinear maximal functions associated with general compact hypersurfaces. Our method is based on the strategy introduced by Barrionuevo et al. [Math. Res. Lett. 25 (2018), pp. 69–1388] and a new multiplier result established by Grafakos, He, and Slavíková [Math. Ann. 376 (2020), pp. 431–455].
Criminology Towards the Metaverse: Cryptocurrency Scams, Grey Economy and the Technosocial
Authors: Mackenzie Simon
Published: February 2022

Online markets in cryptocurrency represent a sprawling and eclectic alternative financial system, selling cutting edge techno-investment schemes that are complex and high risk. Crime control is almost entirely absent from this new crypto economy, and it is full of scams. This paper draws on an ethnography of crypto trading to review the main types of scam, suggesting that the grey economy of cryptocurrency trading is part of a wider evolution of society towards the technosocial, and beyond that perhaps towards the metaversal.
Willing but Unable: How Resources Help Low-Income Mothers Care for their Children and Minimise Child Protection Interventions
Authors: Kuskoff Ella , Parsell Cameron , Plage Stefanie , Ablaza Christine , Perales Francisco
Published: February 2022

Low-income mothers face disproportionately high risks of engaging with statutory child protection systems. Whilst this is often perceived as a result of poor or irresponsible parenting practices, an increasing body of scholarship foregrounds the role of structural issues—such as poverty and homelessness—that constrain mothers’ agency and impact their ability to care for their children. In this article, we examine Australia’s first permanent Supportive Housing for Families (SHF) programme, which offers low-income mothers practical resources to minimise the risk of statutory child protection intervention. Our research aims to understand low-income mothers’ willingness and ability to care for their children, and how mothers engaged with and made meaning of their experiences residing in SHF. Using a qualitative research design, we analyse interview data with programme mothers (n = 17), programme support workers (n = 10) and statutory child protection officers (n = 7). We find that the resources provided through the programme enabled mothers to care for their children in ways that aligned with their parenting beliefs and aspirations. We conclude that SHF programmes may be an effective means through which low-income mothers can overcome the structural barriers that keep them engaged with statutory child protection systems.
Anal Cancer Screening and Prevention: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infection Guidelines
Authors: Barroso Luis F , Stier Elizabeth A , Hillman Richard , Palefsky Joel
Published: February 2022

In June 2019 the Centers for Disease Control and Prevention (CDC) convened an advisory group to assist in development of the 2021 CDC sexually transmitted infections (STI) guidelines. The advisory group on anal cancer screening and prevention met to formulate key questions in this field. The group examined published literature and abstracts to assess evidence and give recommendations for development of the CDC guidelines. This article summarizes key questions, evidence, recommendations, and areas for further research for the screening, diagnosis, and prevention of anal cancer.
Prenatal Influenza Vaccination or Influenza Infection and Autism Spectrum Disorder in Offspring
Authors: Becerra-Culqui Tracy A , Getahun Darios , Chiu Vicki , Sy Lina S , Tseng Hung Fu
Published: February 2022

Background

As prenatal vaccinations continue to be given more frequently, it is important to assess long-term safety events. We investigated the association between prenatal influenza vaccination or infection and autism spectrum disorder (ASD) in offspring.

Methods

A retrospective cohort study of mother–child pairs with deliveries between 1 January 2011 and 31 December 2014 at Kaiser Permanente Southern California was performed. Children aged >1 year were followed through 31 December 2018. Maternal influenza vaccination or infection during pregnancy was obtained from electronic health records. ASD was defined by International Classification of Diseases, Ninth or Tenth Revisions, Clinical Modification, codes after age 1 year. Cox proportional hazard models estimated the crude and inverse probability of treatment weighted (IPTW) hazard ratios (HR) for the association between maternal influenza vaccination or infection and ASD.

Results

There were 84 739 mother–child pairs included in the final analytic sample. Of the 46 257 women vaccinated, 32.4% were vaccinated during the first trimester, 41.8% during the second trimester, and 25.8% during the third trimester. ASD was diagnosed in 1930 (2.3%) children. The IPTW analyses showed no association between prenatal influenza vaccination or infection and ASD in offspring (HR, 1.04; 95% confidence interval [CI], .95–1.13; HR, 1.12; 95% CI, .66–1.89, respectively).

Conclusions

Prenatal influenza vaccination or infection was not associated with ASD risk in offspring. The findings support recommendations to vaccinate pregnant women to protect themselves and their infants, both of whom are vulnerable to severe morbidity following infection.
Right ventricular longitudinal strain in the clinical routine: a state-of-the-art review
Authors: Muraru Denisa , Haugaa Kristina , Donal Erwan , Stankovic Ivan , Voigt Jens Uwe , Petersen Steffen E , Popescu Bogdan A , Marwick Thomas
Published: February 2022

Myocardial deformation imaging is a very attractive clinical tool for the assessment of right ventricular (RV) systolic performance, providing incremental diagnostic and prognostic information over the traditional indices of RV function. Among various imaging modalities, echocardiography is currently the method of choice for clinical assessment of RV longitudinal strain (RVLS). The methodology of 2D speckle-tracking echocardiography to obtain RVLS has been recently standardized and demonstrated to be feasible, accurate, and robust for clinical use. Inter-technique and inter-vendor comparability and reliability of RVLS are improving. RVLS is advantageous because it is more sensitive to subtle changes in myocardial function than conventional parameters used to assess RV function (i.e. tricuspid annular plane systolic excursion, tissue Doppler systolic velocity, fractional area change, or RV ejection fraction) representing a sensitive tool for the long-term follow-up of patients. Proper interpretation of measurements requires a deep understanding of RV mechanics and pathologic tissue characteristics in different cardiovascular conditions, as well as the influence of loading conditions, image properties, and tracking algorithms on RVLS measurements.
A potential future Fontan modification: preliminary in vitro data of a pressure-generating tube from engineered heart tissue
Authors: Köhne Maria , Behrens Charlotta Sophie , Stüdemann Tim , Bibra Constantin von , Querdel Eva , Shibamiya Aya , Geertz Birgit , Olfe Jakob , Hüners Ida , Jockenhövel Stefan , Hübler Michael , Eschenhagen Thomas , Sachweh Jörg Siegmar , Weinberger Florian , Biermann Daniel
Published: February 2022

OBJECTIVES

Univentricular malformations are severe cardiac lesions with limited therapeutic options and a poor long-term outcome. The staged surgical palliation (Fontan principle) results in a circulation in which venous return is conducted to the pulmonary arteries via passive laminar flow. We aimed to generate a contractile subpulmonary neo-ventricle from engineered heart tissue (EHT) to drive pulmonary flow actively.

METHODS

A three-dimensional tubular EHT (1.8-cm length, 6-mm inner diameter, ca. 1-mm wall thickness) was created by casting human-induced pluripotent stem cell-derived cardiomyocytes (0.9 ml, 18 mio/ml) embedded in a fibrin-based hydrogel around a silicone tube. EHTs were cultured under continuous, pulsatile flow through the silicone tube for 23 days.

RESULTS

The constructs started to beat macroscopically at days 8–14 and remained stable in size and shape over the whole culture period. Tubular EHTs showed a coherent beating pattern after 23 days in culture, and isovolumetric pressure measurements demonstrated a coherent pulsatile wave formation with an average frequency of 77 ± 5 beats/min and an average pressure of 0.2 mmHg. Histological analysis revealed cardiomyocytes mainly localized along the inner and outer curvature of the tubular wall with mainly longitudinal alignment. Cell density in the center of the tubular wall was lower.

CONCLUSIONS

A simple tube-shaped contractile EHT was generated from human-induced pluripotent stem cells and developed a synchronous beating pattern. Further steps need to focus on optimizing support materials, flow rates and geometry to obtain a construct that creates sufficient pressures to support a directed and pulsatile blood flow.
A growth area
Authors: Decrausaz Sarah-Louise , Cameron Michelle E
Published: February 2022

Studies of living children demonstrate that early life stress impacts linear growth outcomes. Stresses affecting linear growth may also impact later life health outcomes, including increased cardiometabolic disease risk. Palaeopathologists also assess the growth of children recovered from bioarchaeological contexts. Early life stresses are inferred to affect linear growth outcomes, and measurements of skeletal linear dimensions alongside other bioarchaeological information may indicate the types of challenges faced by past groups. In clinical settings, the impacts of stress on growing children are typically measured by examining height. Palaeopathologists are limited to examining bone dimensions directly and must grapple with incomplete pictures of childhood experiences that may affect growth. Palaeopathologists may use clinical growth studies to inform observations among past children; however, there may be issues with this approach. Here, we review the relationship between contemporary and palaeopathological studies of child and adolescent growth. We identify approaches to help bridge the gap between palaeopathological and biomedical growth studies. We advocate for: the creation of bone-specific growth reference information using medical imaging and greater examination of limb proportions; the inclusion of children from different global regions and life circumstances in contemporary bone growth studies; and greater collaboration and dialogue between palaeopathologists and clinicians as new studies are designed to assess linear growth past and present. We advocate for building stronger bridges between these fields to improve interpretations of growth patterns across human history and to potentially improve interventions for children living and growing today.
Metabolic/bariatric surgery protects against cardiovascular disease
Authors: Mingrone Geltrude , Castagneto-Gissey Lidia , Bornstein Stefan R
Published: February 2022

This editorial refers to ‘Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis', by S. L. van Veldhuisen et al., https://doi.org/10.1093/eurheartj/ehac071.
Seismic anisotropy beneath the Kumaun–Garhwal Himalaya using core-refracted shear wave phases
Authors: Kumar V Pavan , Gupta Sandeep , Borah Kajaljyoti , Prakasam K S , Rai S S
Published: February 2022

We investigate the nature of seismic anisotropy in the Kumaun–Garhwal Himalaya by analysing the core-refracted shear wave splitting phases (SK(K)S, PKS) recorded at 42 broad-band seismic stations. The mean fast anisotropy directions are mostly in ∼E–W and a few in the ∼NE–SW directions. The mean delay time decreases progressively from ∼1.0 s beneath the Sub Himalaya to ∼0.5 s at the Higher Himalaya. The observed seismic anisotropy suggests that the ongoing deformation beneath the Kumaun–Garhwal Himalaya has a large contribution by the relative rotation of the asthenospheric flow by the compression along the Indian Plate motion direction in this collision zone. Also, the southward transportation of the mid-crustal flow is probably responsible for the reduction in the delay times in the Main Central Thrust zone and further north than in the Sub-to-Lower Himalaya. The splitting parameters indicate a complex pattern of deformation beneath the Kumaun–Garhwal Himalaya with contribution from crust, lithospheric mantle and asthenospheric mantle.
Influence of PRKCE non-synonymous variants on protein dynamics and functionality
Authors: Khan Khushbukhat , Shah Hania , Rehman Areeba , Badshah Yasmin , Ashraf Naeem M , Shabbir Maria
Published: February 2022

Novel protein kinase C (nPKC) family member, protein kinase C epsilon (PKCε) is an AGC kinase superfamily member. It is associated with neurological and metabolic diseases as well as human cancers. No study so far has been conducted to identify genetic variations and their effect on PKCε folding and functioning. The present study aimed to identify mutational hotspots in PKCε and disease-causing non-synonymous variants (nsSNPs) along with the investigation of nsSNP impact on protein dynamics. Twenty-nine in silico tools were applied to determine nsSNP deleteriousness, their impact on protein dynamics and disease association, along with the prediction of PKCε post-translational modification (PTM) sites. The present study’s outcomes indicated that most nsSNPs were concentrated in the PKCε hinge region and C-terminal tail. Most pathogenic variants mapped to the kinase domain. Regulatory domain variants influenced PKCε interaction with molecular players whereas kinase domain variants were predicted to impact its phosphorylation pattern and protein–protein interactions. Most PTM sites were mapped to the hinge region. PKCε nsSNPs have an association with oncogenicity and its expression dysregulation is responsible for poor overall survival. Understanding nsSNP structural impact is a primary step necessary for delineating the relationship of genetic level differences with protein phenotype. The obtained knowledge can eventually help in disease diagnosis and therapy design.
Surgical Apgar score could predict complications after esophagectomy: a systematic review and meta-analysis
Authors: Zheng Chao , Luo Chao , Xie Kai , Li Jiang-Shan , Zhou Hai , Hu Li-Wen , Wang Gao-Ming , Shen Yi
Published: February 2022

OBJECTIVES

Esophagectomy is the most effective treatment for oesophageal cancer, although the incidence of postoperative complications remains high. Severe major complications, such as intrathoracic anastomotic leakage, are costly and life-threatening to patients. Therefore, early identification of postoperative complications is essential. The surgical Apgar score (SAS) was introduced by Gawande and colleagues to predict major complications after oesophagectomy. Several studies were carried out with inconsistent results.

METHODS

PubMed, Embase, Web of Science, ClinicalTrials.gov and the Cochrane Library were searched for studies regarding SAS and oesophagectomy. Forest plots were generated using a random-effects model to investigate the actual predictive value of SAS in identifying major complications after oesophagectomy.

RESULTS

Nine retrospective cohort studies were finally identified from selected electronic databases. The meta-analysis demonstrated that SAS could forecast the incidence of postoperative complications (odds ratio = 1.82, 95% confidence interval: 1.43–2.33, P < 0.001). Subgroup analysis validated the predictive value of SAS whether as continuous or discrete variables. In addition, a meta-analysis of 4 studies demonstrated that SAS could predict the incidence of pulmonary complications (odds ratio = 2.32, 95% confidence interval: 1.61–3.36, P < 0.001). Significant heterogeneity but no publication bias was found.

CONCLUSIONS

Lower SAS scores could predict the incidence of major morbidities and pulmonary complications after oesophagectomy. Significant heterogeneity limits the reliability of the results, even if publication bias is not observed. More high-quality prospective research should be conducted to verify the findings. PROSPERO registration ID: CRD42020209004.
Ambient air pollution, healthy diet and vegetable intakes, and mortality: a prospective UK Biobank study
Authors: Wang Mengying , Zhou Tao , Song Qiying , Ma Hao , Hu Yonghua , Heianza Yoriko , Qi Lu
Published: February 2022

Background

Recent studies suggest potential interactions of air pollutants with dietary factors and genetic susceptibility on mortality risk; however, evidence from prospective studies is still lacking. We aimed to assess the association between air pollution and mortality, and investigate the modification effects of a healthy diet and genetic susceptibility.

Methods

A total of 386 937 participants were enrolled from 2006 to 2010 and followed up to 2018 in the UK Biobank study. The annual average air pollutant concentrations of particulate matter (PM) with diameters ≤2.5 (PM2.5), ≤10 (PM10) and between 2.5 and 10 µm (PM2.5–10) and nitrogen oxides (NO2 and NOx) were calculated and linked to participants’ residential addresses. Healthy dietary patterns were evaluated by a healthy diet score (HDS) based on intakes of vegetables, fruit, fish, unprocessed red meat and processed meat. We also calculated genetic risk score (GRS) of the lifespan. We examined potential interactions by setting variable cross-product terms of air pollutants with diets or GRS in the models.

Results

We identified 11 881 deaths [2426 from cardiovascular diseases (CVD), 1211 from coronary heart disease (CHD) and 466 from stroke] during a median follow-up of 8.9 years. We found that PM2.5 [hazard ratio (HR), 1.27; 95% CI, 1.05–1.55], PM10 (HR, 1.18; 95% CI, 1.04–1.34), NO2 (HR, 1.05; 95% CI, 1.01–1.08), and NOx (HR, 1.02; 95% CI, 1.01–1.03) were associated with all-cause mortality. PM2.5 was also associated with increased risks of CVD mortality (HR, 1.68; 95% CI, 1.10–2.56) and CHD mortality (HR, 2.08; 95% CI, 1.16–3.75). In addition, we found that adherence to healthy dietary patterns modified associations of PM2.5, NO2 and NOx with all-cause mortality (P-interaction = 0.006, 0.006 and 0.02, respectively). Among the individual dietary components, vegetable intakes showed interactions with PM2.5, NO2 and NOx (P-interaction = 0.007, 0.004 and 0.02, respectively). The associations between air pollutants and increased risks of all-cause mortality were attenuated among participants with higher vegetable intakes. We did not observe interactions between air pollutants and HDS on CVD, CHD or stroke mortality (P-interaction > 0.05). Besides, we did not find interactions between air pollutants and genetic risk for lifespan on mortality risk.

Conclusion

This study provides evidence linking long-term exposure to various air pollutants to the risk of all-cause, CVD and CHD mortality, and the potential attenuation of a healthy diet, especially high vegetable intakes, on such relations. Our findings highlight the importance of adherence to a healthy diet in lowering ambient air-pollution-related mortality risk.
Interventions developed to reduce secondary care utilisation in patients with type 2 diabetes mellitus: a narrative review
Authors: Khayyat Sarah M , Walters Philippa A , Whittlesea Cate , Nazar Hamde
Published: February 2022

Objectives

To identify, describe and critically appraise the quality of studies of interventions developed to reduce the rate of secondary care utilisation and investigate interventions’ impact on patients with type 2 diabetes mellitus (T2DM).

Method

Using a systematic approach, five databases were searched between 01 January 1995 and 01 February 2021 (MEDLINE, EMBASE, PsycINFO, CINAHL and Cochrane database). Inclusion criteria were studies (published in English) in adults with T2DM offered intervention(s) involving medicines/services/educational programmes in any country or setting, with investigated outcomes including the rate of hospital admission/re-admission/accident and emergency visits. Validated tools were used to assess the quality and accuracy of reporting the interventions. A narrative synthesis was used to frame the findings.

Key findings

A total of 4670 papers were identified, which yielded a final 53 studies after screening against the inclusion criteria. Identified interventions were complex interventions (n = 21) including at least two interventions (e.g. improving medication adherence and patient education), medication management (n = 15), patient education programmes (n = 8), lifestyle interventions (n = 5) and other interventions (n = 4; e.g. dental care). After assessing for quality and effectiveness of interventions, 15 studies remained; 7 were medication management interventions (e.g. use of insulin pen) and 8 were complex interventions (e.g. pharmaceutical care and telehealth systems). Complex interventions showed significant improvement in clinical outcomes and reduction in secondary care utilisation.

Conclusions

This narrative review identified potential elements of an effective complex intervention to reduce healthcare utilisation in patients with T2DM. These results could inform the development of interventions to be tested for feasibility, before piloting to assess for outcomes that improve diabetic care, reduce diabetes-related complications and minimise healthcare utilisation.
Advances in understanding the mechanisms of repairing damaged nuclear envelop
Authors: Kamikawa Yasunao , Imaizumi Kazunori
Published: February 2022

The nuclear envelope (NE) separates genomic DNA from the cytoplasm in eukaryotes. The structure of the NE is dynamically altered not only in mitotic disassembly and reassembly but also during interphase. Recent studies have shown that the NE is frequently damaged by various cellular stresses that degenerate NE components and/or disrupt their functional interactions. These stresses are referred to as ‘NE stress’. Accumulating evidence has demonstrated that NE stress potentially causes severe cellular dysfunctions, such as cell death and genome instability. In this review, the concept of NE stress, the processes repairing damage of the NE caused by NE stress, and the molecular mechanisms by which NE stress contributes to disease pathogenesis are introduced.
Distribution patterns of South American mustelids (Carnivora: Mustelidae)
Authors: Schiaffini Mauro Ignacio
Published: February 2022

Climate has long been recognized as one of the main determinants of the geographical distribution of species. Variations associated with primary productivity in temperature, rainfall, and photoperiod can affect survival and reproduction, affecting the peripheries of geographical distributions. The importance of graphical visualization of these distributions lies in conservation, management, and environmental research. With respect to the South American species of mustelids, 37% are threatened according to the IUCN Red List, and the limits of distributions and their determinants are poorly known for the majority of species. Here, complete and updated databases and maps of geographical and temporal distribution are presented for the 12 species of mustelids inhabiting South America. Museum specimens and recorded localities were gathered based on an online search. Geographic limits of distributions were assessed, as were environmental values for all localities. Comparison with IUCN maps was undertaken to determine the need for updating. Finally, sympatry and syntopy among species analyzed were examined using Geographic Information Systems. The most complete and updated database of geographic distributions of South American mustelids to date was assembled for all species, encompassing 9,826 localities. New areas with recorded localities not present in IUCN maps were documented in many species, indicating the need to update current maps for conservation efforts. Areas of sympatry and syntopy were found among many species, indicating that patterns of coexistence between them are not well known. This study will serve as a framework for ensuing efforts in species distribution modeling, conservation decisions, and field studies, among others.
Metastatic renal cell carcinoma presenting as chronic bleeding from the stomach: a rare case report
Authors: Tapasak Brandon , Mcguirt Aron
Published: February 2022

Renal cell carcinoma (RCC) most commonly metastasizes to the lung, adrenals, brain and pancreas, but metastasis to the stomach is uncommon. We present a 77-year-old male who underwent left nephrectomy 9 years previously for RCC with known metastatic disease to the lungs, diaphragm and stomach, and required multiple transfusions for acute blood loss anemia. A previous esophagogastroduodenoscopy revealed a large, friable, ulcerated mass at the gastric cardia. Biopsies of the mass demonstrated clear-cell carcinoma compatible with metastatic RCC. After multiple attempts at endoscopic, procedures and embolization were unsuccessful at controlling bleeding, the patient was treated with palliative total gastrectomy with Roux-en-Y gastric bypass. At discharge, the patient had been hemodynamically stable and tolerating a liquid diet. This case report highlights the presenting symptomology of RCC, explores the rarity of gastric metastases, and reviews current literature on management strategies for these patients.
Spectrums of in/formality and il/legality: Negotiating business and migration-related statuses in arrival spaces
Authors: Biehl Kristen Sarah
Published: February 2022

Across global cities of the world, urban spaces of arrival tend to be characterized by a multiplicity of informal practices, and therefore also marginality, being most prevalent in relation to local economic practices, and increasingly more the legal status of foreigner migrants residing in such spaces. This article aims to understand these dynamics in arrival spaces at the margins by exploring both domains in a unique manner. Over recent decades, urban and migration studies have separately given rise to new research that is critical of the pervasive binary views around formal versus informal economies and legal versus illegal migrations. Drawing on this literature, and ethnographic fieldwork carried out in an Istanbul locality that has served as a zone of arrival for varying migration flows over several decades, this article examines how both business proprietors and migrants working and/or residing in the locality actively and continuously re-negotiate their positions within spectrums of in/formality and il/legality. It shows that arrival spaces at the margins are places of intense calculation and that the chosen direction along these spectrums depends on an evaluation of all kinds of social, political, spatial, and temporal factors transpiring at a particular moment and place. In focusing on this processual nature of in/formalities and il/legalities, the article also suggests reconsidering various other dualities, including margins versus center, exclusion versus inclusion, and arrival versus settlement, and argues that the intensity of having to manage one’s experiences of these dualities is what really distinguishes inhabiting arrival spaces at the margins in today’s global cities.
Cosmicflows-4: the baryonic Tully–Fisher relation providing ∼10 000 distances
Authors: Kourkchi Ehsan , Tully R Brent , Courtois Hélène M , Dupuy Alexandra , Guinet Daniel
Published: February 2022

The interstellar gas in spiral galaxies can constitute a significant fraction of the baryon mass and it has been demonstrated that the sum of stellar and gas components correlates well with the kinematic signature of the total mass content, the widths of H i line profiles. The correlation of baryonic mass with H i linewidths is used here to obtain distances for 9984 galaxies extending to ∼0.05c. The sample is H i flux limited and a correction is required to account for an H i selection bias. The absolute scale is established by 64 galaxies with known distances from studies of Cepheid variables and/or the magnitudes of stars at the tip of the red giant branch. The calibration of the baryonic relationship results in a determination of the Hubble constant of H0 = 75.5 ± 2.5 km s−1 Mpc−1. The error estimate is statistical. This material will be combined with contributions from other methodologies in a subsequent paper where systematic uncertainties will be investigated.
Strong-lensing source reconstruction with variationally optimized Gaussian processes
Authors: Karchev Konstantin , Coogan Adam , Weniger Christoph
Published: February 2022

Strong-lensing images provide a wealth of information both about the magnified source and about the dark matter distribution in the lens. Precision analyses of these images can be used to constrain the nature of dark matter. However, this requires high-fidelity image reconstructions and careful treatment of the uncertainties of both lens mass distribution and source light, which are typically difficult to quantify. In anticipation of future high-resolution data sets, in this work we leverage a range of recent developments in machine learning to develop a new Bayesian strong-lensing image analysis pipeline. Its highlights are (a) a fast, GPU-enabled, end-to-end differentiable strong-lensing image simulator; (b) a new, statistically principled source model based on a computationally highly efficient approximation to Gaussian processes that also takes into account pixellation; and (c) a scalable variational inference framework that enables simultaneously deriving posteriors for tens of thousands of lens and source parameters and optimizing hyperparameters via stochastic gradient descent. Besides efficient and accurate parameter estimation and lens model uncertainty quantification, the main aim of the pipeline is the generation of training data for targeted simulation-based inference of dark matter substructure, which we will exploit in a companion paper.
AstroSat observation of X-ray dips and state transition in the black hole candidate MAXI J1803–298
Authors: Jana Arghajit , Naik Sachindra , Jaisawal Gaurava K , Chhotaray Birendra , Kumari Neeraj , Gupta Shivangi
Published: February 2022

We present the results obtained from broad-band X-ray timing and spectral analysis of black hole (BH) candidate MAXI J1803–298 using an AstroSat observation on 2021 May 11–12. Four periodic absorption dips with a periodicity of 7.02 ± 0.18 h are detected in the light curve. AstroSat observe the source when it was undergoing a transition from hard-intermediate state to soft-intermediate state. Our timing analysis reveals the presence of a sharp Type-C quasi-periodic oscillation (QPO) in the power-density spectra (PDS) with an evolving QPO frequency ranging from 5.31 ± 0.02 to 7.61 ± 0.09 Hz. We investigate the energy dependence of the QPO and do not find this feature in the PDS above 30 keV. The combined 0.7–80 keV SXT and LAXPC spectra are fitted with a model consisting of thermal multi-colour blackbody emission and Comptonized emission components. We perform time-resolved spectroscopy by extracting spectra during the dip and non-dip phases of the observation. A neutral absorber is detected during the dip and non-dip phases though a signature of an ionized absorber is also present in the dip phases. The spectral and temporal parameters are found to evolve during our observation. We estimate the mass function of the system as f(M) = 2.1–7.2 M⊙ and the mass of the BH candidate in the range of MBH ∼ 3.5–12.5 M⊙.
Modelling the gamma-ray morphology of HESSJ1804−216 from two supernova remnants in a hadronic scenario
Authors: Feijen K , Einecke S , Rowell G , Braiding C , Burton M G , Wong G F
Published: February 2022

HESS J1804−216 is one of the brightest yet most mysterious TeV γ-ray sources discovered to date. Previous arc-minute scale studies of the interstellar medium (ISM) surrounding this TeV γ-ray source revealed  HESS J1804−216 is likely powered by a mature supernova remnant (SNR) or pulsar, hence its origin remains uncertain. In this paper, we focus on the diffusive escape of cosmic ray protons from potential SNR accelerators. These cosmic rays interact with the ISM to produce TeV γ-rays. We utilize the isotropic diffusion equation solution for particles escaping from a shell, to model the energy-dependent escape and propagation of protons into the ISM. This work is the first attempt at modelling the spatial morphology of γ-rays towards  HESS J1804−216, using arc-minute ISM observations from both Mopra and the Southern Galactic Plane Survey. The spectral and spatial distributions of γ-rays for the two nearby potential SNR counterparts, SNR G8.7−0.1 and the progenitor SNR of PSR J1803−2137, are presented here. We vary the diffusion parameters and particle spectrum and use a grid search approach to find the best combination of model parameters. We conclude that moderately slow diffusion is required for both candidates. The most promising candidate to be powering the TeV  γ-rays from HESS J1804−216 in a hadronic scenario is the progenitor SNR of PSR J1803−2137.
Simulations of 60Fe entrained in ejecta from a near-Earth supernova: effects of observer motion
Authors: Chaikin Evgenii , Kaurov Alexander A , Fields Brian D , Correa Camila A
Published: February 2022

Recent studies have shown that live (not decayed) radioactive 60Fe is present in deep-ocean samples, Antarctic snow, lunar regolith, and cosmic rays. 60Fe represents supernova (SN) ejecta deposited in the Solar system around $3 \, \rm Myr$ ago, and recently an earlier pulse ${\approx}7 \ \rm Myr$ ago has been found. These data point to one or multiple near-Earth SN explosions that presumably participated in the formation of the Local Bubble. We explore this theory using 3D high-resolution smooth-particle hydrodynamical simulations of isolated SNe with ejecta tracers in a uniform interstellar medium (ISM). The simulation allows us to trace the SN ejecta in gas form and those eject in dust grains that are entrained with the gas. We consider two cases of diffused ejecta: when the ejecta are well-mixed in the shock and when they are not. In the latter case, we find that these ejecta remain far behind the forward shock, limiting the distance to which entrained ejecta can be delivered to ≈100 pc in an ISM with $n_\mathrm{H}=0.1\,\, \rm cm^{-3}$ mean hydrogen density. We show that the intensity and the duration of 60Fe accretion depend on the ISM density and the trajectory of the Solar system. Furthermore, we show the possibility of reproducing the two observed peaks in 60Fe concentration with this model by assuming two linear trajectories for the Solar system with 30-km s−1 velocity. The fact that we can reproduce the two observed peaks further supports the theory that the 60Fe signal was originated from near-Earth SNe.
Comparison of genome architecture at two stages of male germline cell differentiation inDrosophila
Authors: Ilyin Artem A , Kononkova Anna D , Golova Anastasia V , Shloma Viktor V , Olenkina Oxana M , Nenasheva Valentina V , Abramov Yuri A , Kotov Alexei A , Maksimov Daniil A , Laktionov Petr P , Pindyurin Alexey V , Galitsyna Aleksandra A , Ulianov Sergey V , Khrameeva Ekaterina E , Gelfand Mikhail S , Belyakin Stepan N , Razin Sergey V , Shevelyov Yuri Y
Published: February 2022

Eukaryotic chromosomes are spatially segregated into topologically associating domains (TADs). Some TADs are attached to the nuclear lamina (NL) through lamina-associated domains (LADs). Here, we identified LADs and TADs at two stages of Drosophila spermatogenesis – in bamΔ86 mutant testes which is the commonly used model of spermatogonia (SpG) and in larval testes mainly filled with spermatocytes (SpCs). We found that initiation of SpC-specific transcription correlates with promoters’ detachment from the NL and with local spatial insulation of adjacent regions. However, this insulation does not result in the partitioning of inactive TADs into sub-TADs. We also revealed an increased contact frequency between SpC-specific genes in SpCs implying their de novo gathering into transcription factories. In addition, we uncovered the specific X chromosome organization in the male germline. In SpG and SpCs, a single X chromosome is stronger associated with the NL than autosomes. Nevertheless, active chromatin regions in the X chromosome interact with each other more frequently than in autosomes. Moreover, despite the absence of dosage compensation complex in the male germline, randomly inserted SpG-specific reporter is expressed higher in the X chromosome than in autosomes, thus evidencing that non-canonical dosage compensation operates in SpG.
Mass spectrometry-based technologies for probing the 3D world of plant proteins
Authors: Blackburn Matthew R , Minkoff Benjamin B , Sussman Michael R
Published: February 2022

Over the past two decades, mass spectrometric (MS)-based proteomics technologies have facilitated the study of signaling pathways throughout biology. Nowhere is this needed more than in plants, where an evolutionary history of genome duplications has resulted in large gene families involved in posttranslational modifications and regulatory pathways. For example, at least 5% of the Arabidopsis thaliana genome (ca. 1,200 genes) encodes protein kinases and protein phosphatases that regulate nearly all aspects of plant growth and development. MS-based technologies that quantify covalent changes in the side-chain of amino acids are critically important, but they only address one piece of the puzzle. A more crucially important mechanistic question is how noncovalent interactions—which are more difficult to study—dynamically regulate the proteome’s 3D structure. The advent of improvements in protein 3D technologies such as cryo-electron microscopy, nuclear magnetic resonance, and X-ray crystallography has allowed considerable progress to be made at this level, but these methods are typically limited to analyzing proteins, which can be expressed and purified in milligram quantities. Newly emerging MS-based technologies have recently been developed for studying the 3D structure of proteins. Importantly, these methods do not require protein samples to be purified and require smaller amounts of sample, opening the wider proteome for structural analysis in complex mixtures, crude lysates, and even in intact cells. These MS-based methods include covalent labeling, crosslinking, thermal proteome profiling, and limited proteolysis, all of which can be leveraged by established MS workflows, as well as newly emerging methods capable of analyzing intact macromolecules and the complexes they form. In this review, we discuss these recent innovations in MS-based “structural” proteomics to provide readers with an understanding of the opportunities they offer and the remaining challenges for understanding the molecular underpinnings of plant structure and function.
Antiracism without Races: How Activists Produce Knowledge about Race and Policing in France
Authors: Boutros Magda
Published: February 2022

Scholars have argued that anti-racialist ideologies – which deem racial categorization dangerous and racist – are an obstacle to antiracism, because they make race and its effects invisible, and obscure institutional and structural racism. This paper reexamines this argument empirically, by analyzing how activists resist “racial ignorance” and produce knowledge about race in anti-racialist contexts. Drawing on race scholarship, social movement theory, and sociology of knowledge, I ask: How do social movements produce knowledge about the role of race in policing in France? What are the implications of different epistemic practices for activists’ racial conceptualizations and political practice? The article is based on an ethnography of three mobilizations contesting policing in France. The comparative methodology reveals that epistemic practices play a role in shaping how mobilizations reach a shared understanding of race and racism. Specifically, how knowledge projects determine racial difference, the methodologies used to capture racial inequality/oppression, and the level of analysis, all matter for the understanding of racism that activists are able to substantiate. Mobilization’s epistemic approaches provide some activists with additional resources to promote their preferred racial conceptualizations and can produce the evidence needed to change the mobilization’s dominant discourse, from individualistic to structural and systemic conceptualizations of racism.