bluuebunny/crossref_metadata_2025 huggingface dataset:
S-Figure-3 from Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma
Authors: Liu Yan , Li Yuyang , Wang Xiaoen , Liu Feiyang , Gao Peng , Quinn Max M. , Li Fei , Merlino Ashley A. , Benes Cyril , Liu Qingsong , Gray Nathanael S. , Wong Kwok-Kin
Published: April 2023

MRI images of of Kras/p53/Lkb1 lung tumors
Supplemental information from Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination
Authors: Jiang Hong , Rivera-Molina Yisel , Gomez-Manzano Candelaria , Clise-Dwyer Karen , Bover Laura , Vence Luis M. , Yuan Ying , Lang Frederick F. , Toniatti Carlo , Hossain Mohammad B. , Fueyo Juan
Published: April 2023

Supplemental materials and methods
Figure 3 from Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination
Authors: Jiang Hong , Rivera-Molina Yisel , Gomez-Manzano Candelaria , Clise-Dwyer Karen , Bover Laura , Vence Luis M. , Yuan Ying , Lang Frederick F. , Toniatti Carlo , Hossain Mohammad B. , Fueyo Juan
Published: April 2023

PD-L1 expression in mouse glioma GL261-EGFP cells.
Supplementary Data from Akt Signaling Is Sustained by a CD44 Splice Isoform–Mediated Positive Feedback Loop
Authors: Liu Sali , Cheng Chonghui
Published: April 2023

This supplemental file contains data that support the claims and results described in the main manuscript. Supplementary Figure S1. HAS2 is upregulated in response to CD44s overexpression. Supplementary Figure S2. TCGA data analysis of CD44v and HAS2 expression in breast cancer. Supplementary Figure S3. TCGA data analysis of CD44 isoforms and HAS2 expression. Supplementary Figure S4. HAS2/HA activates Akt signaling in a CD44s-dependent manner. Supplementary Figure S5. CD44s-mediated Akt activation is attenuated by depletion of HA or addition of CD44 antibodies. Supplementary Figure S6. Effects of FOXO family proteins on HAS2 promoter activity. Supplementary Figure S7. Inhibition of HAS2 reduces mammosphere forming ability.
Supplementary Figures from A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers
Authors: Guo Theresa , Sakai Akihiro , Afsari Bahman , Considine Michael , Danilova Ludmila , Favorov Alexander V. , Yegnasubramanian Srinivasan , Kelley Dylan Z. , Flam Emily , Ha Patrick K. , Khan Zubair , Wheelan Sarah J. , Gutkind J. Silvio , Fertig Elana J. , Gaykalova Daria A. , Califano Joseph
Published: April 2023

SFigure 1. Distribution of ASEs present within each tumor. SFigure2. AKT3 splice variant expression by qRT-PCR in a panel of 20 cell lines. SFigure 3. Western blot analysis of canonical AKT1 pathway after transient knockdown of AKT3 splice variant. SFigure 4. Correlation of AKT3 splice variant with other PI3K/AKT pathway mutations in TCGA.
Supplementary figure legends from PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma
Authors: Yoshino Hirofumi , Nohata Nijiro , Miyamoto Kazutaka , Yonemori Masaya , Sakaguchi Takashi , Sugita Satoshi , Itesako Toshihiko , Kofuji Satoshi , Nakagawa Masayuki , Dahiya Rajvir , Enokida Hideki
Published: April 2023

Supplementary figure legends
Supplemental Table 2 from A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers
Authors: Guo Theresa , Sakai Akihiro , Afsari Bahman , Considine Michael , Danilova Ludmila , Favorov Alexander V. , Yegnasubramanian Srinivasan , Kelley Dylan Z. , Flam Emily , Ha Patrick K. , Khan Zubair , Wheelan Sarah J. , Gutkind J. Silvio , Fertig Elana J. , Gaykalova Daria A. , Califano Joseph
Published: April 2023

Summary of sample cohort clinical data in tumors and normal samples including age, gender, race, smoking history, TNM stage, recurrence, follow up time, survival and HPV status
Supplementary Table 2 from PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma
Authors: Yoshino Hirofumi , Nohata Nijiro , Miyamoto Kazutaka , Yonemori Masaya , Sakaguchi Takashi , Sugita Satoshi , Itesako Toshihiko , Kofuji Satoshi , Nakagawa Masayuki , Dahiya Rajvir , Enokida Hideki
Published: April 2023

metabolites infomation
Supplemental Table 1 from A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers
Authors: Guo Theresa , Sakai Akihiro , Afsari Bahman , Considine Michael , Danilova Ludmila , Favorov Alexander V. , Yegnasubramanian Srinivasan , Kelley Dylan Z. , Flam Emily , Ha Patrick K. , Khan Zubair , Wheelan Sarah J. , Gutkind J. Silvio , Fertig Elana J. , Gaykalova Daria A. , Califano Joseph
Published: April 2023

Designed primer sequences for wild type AKT3 and variant AKT3 for qRT-PCR analysis as well as custom siRNA sequences
Figure S3 from PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma
Authors: Yoshino Hirofumi , Nohata Nijiro , Miyamoto Kazutaka , Yonemori Masaya , Sakaguchi Takashi , Sugita Satoshi , Itesako Toshihiko , Kofuji Satoshi , Nakagawa Masayuki , Dahiya Rajvir , Enokida Hideki
Published: April 2023

In vitro experiments
Supplementary figure legends from Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence
Authors: Bainor Anthony J. , Deng Fang-Ming , Wang Yu , Lee Peng , Cantor David J. , Logan Susan K. , David Gregory
Published: April 2023

This file contains the figure legends for each of the supplementary figures 1-5. Figure S1: Deletion of Sin3b does not impair loss of PTEN-driven AKT activation in the prostate anterior lobe. IHC stainings for SIN3B, PTEN, and pAKT of the anterior lobe of prostates taken from 3-month-old mice of each genotype. Figure S2: Images of 12-month-old prostates from each genotype before removal from the mouse. Sin3bpc-/- Ptenpc-/- tumors originate from the prostate epithelium as evidenced by their positive staining for both AR and CK18. Figure S3: SIN3B protects against loss-of-PTEN-induced proliferation. KI67 staining using the dorsolateral lobe of prostates taken from 6- and 12-month-old mice. Figure S4: SIN3B has no effect on immune cell infiltration. Quantification of immune cell infiltration by flow cytometry. Figure S5: The SIN3B complex is differentially regulated in human PCa. Oncoprint plot of SIN3B, SIN3A, and significantly co-occurring SIN3B target genes. Survival curves of six SIN3B target genes that are upregulated in PCa which demonstrate a decreased disease-free survival rate.
Figure S2 from Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding
Authors: Lv Deguan , Jia Feng , Hou Yanli , Sang Youzhou , Alvarez Angel A. , Zhang Weiwei , Gao Wei-Qiang , Hu Bo , Cheng Shi-Yuan , Ge Jianwei , Li Yanxin , Feng Haizhong
Published: April 2023

Effects of KAT6B and KAT5 on AKT phosphorylation and PIK3CA expression.
Figure S4 from Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence
Authors: Bainor Anthony J. , Deng Fang-Ming , Wang Yu , Lee Peng , Cantor David J. , Logan Susan K. , David Gregory
Published: April 2023

SIN3B has no effect on immune cell infiltration. Quantification of immune cell infiltration by flow cytometry.
Figure S4 Tumour growth upon ATRi and Gemcitabine Treatment in Allografts model from ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage
Authors: Perkhofer Lukas , Schmitt Anna , Romero Carrasco Maria Carolina , Ihle Michaela , Hampp Stephanie , Ruess Dietrich Alexander , Hessmann Elisabeth , Russell Ronan , Lechel André , Azoitei Ninel , Lin Qiong , Liebau Stefan , Hohwieler Meike , Bohnenberger Hanibal , Lesina Marina , Algül Hana , Gieldon Laura , Schröck Evelin , Gaedcke Jochen , Wagner Martin , Wiesmüller Lisa , Sipos Bence , Seufferlein Thomas , Reinhardt Hans Christian , Frappart Pierre-Olivier , Kleger Alexander
Published: April 2023

Tumour growth upon ATRi and Gemcitabine Treatment in Allografts model
Figure S3 Tumour growth upon Olaparib and Gemcitabine Treatment in Allografts model from ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage
Authors: Perkhofer Lukas , Schmitt Anna , Romero Carrasco Maria Carolina , Ihle Michaela , Hampp Stephanie , Ruess Dietrich Alexander , Hessmann Elisabeth , Russell Ronan , Lechel André , Azoitei Ninel , Lin Qiong , Liebau Stefan , Hohwieler Meike , Bohnenberger Hanibal , Lesina Marina , Algül Hana , Gieldon Laura , Schröck Evelin , Gaedcke Jochen , Wagner Martin , Wiesmüller Lisa , Sipos Bence , Seufferlein Thomas , Reinhardt Hans Christian , Frappart Pierre-Olivier , Kleger Alexander
Published: April 2023

Tumour growth upon Olaparib and Gemcitabine Treatment in Allografts model
Supplemental Table 1 from Nuclear CD24 Drives Tumor Growth and Is Predictive of Poor Patient Prognosis
Authors: Duex Jason E. , Owens Charles , Chauca-Diaz Ana , Dancik Garrett M. , Vanderlinden Lauren A. , Ghosh Debashis , Leivo Mariah Z. , Hansel Donna E. , Theodorescu Dan
Published: April 2023

List of 304 genes which were found to have statistically significant differential expression between UMUC13 cells expressing NLS-CD24 and Wt-CD24.
Supp Figure 4 from Nuclear CD24 Drives Tumor Growth and Is Predictive of Poor Patient Prognosis
Authors: Duex Jason E. , Owens Charles , Chauca-Diaz Ana , Dancik Garrett M. , Vanderlinden Lauren A. , Ghosh Debashis , Leivo Mariah Z. , Hansel Donna E. , Theodorescu Dan
Published: April 2023

Inhibiting nuclear export with Leptomycin B leads to nuclear accumulation of CD24 protein.
Supplementary Table 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Authors: Vandyke Kate , Zeissig Mara N. , Hewett Duncan R. , Martin Sally K. , Mrozik Krzysztof M. , Cheong Chee Man , Diamond Peter , To L. Bik , Gronthos Stan , Peet Daniel J. , Croucher Peter I. , Zannettino Andrew C.W.
Published: April 2023

GSEA for genes upregulated by overexpression of HIF-2alpha in LP-1 cells
Supplementary Figure Legends from Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine
Authors: Goto Norihiro , Ueo Taro , Fukuda Akihisa , Kawada Kenji , Sakai Yoshiharu , Miyoshi Hiroyuki , Taketo Makoto Mark , Chiba Tsutomu , Seno Hiroshi
Published: April 2023

Supplementary Figure Legends
Supplemental table 4 from Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies
Authors: Bui Mai H. , Lin Xiaoyu , Albert Daniel H. , Li Leiming , Lam Lloyd T. , Faivre Emily J. , Warder Scott E. , Huang Xiaoli , Wilcox Denise , Donawho Cherrie K. , Sheppard George S. , Wang Le , Fidanze Steve , Pratt John K. , Liu Dachun , Hasvold Lisa , Uziel Tamar , Lu Xin , Kohlhapp Fred , Fang Guowei , Elmore Steven W. , Rosenberg Saul H. , McDaniel Keith F. , Kati Warren M. , Shen Yu
Published: April 2023

Apoptosis induction by MS417 across cancer cell lines
Supplemental table 3 from Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies
Authors: Bui Mai H. , Lin Xiaoyu , Albert Daniel H. , Li Leiming , Lam Lloyd T. , Faivre Emily J. , Warder Scott E. , Huang Xiaoli , Wilcox Denise , Donawho Cherrie K. , Sheppard George S. , Wang Le , Fidanze Steve , Pratt John K. , Liu Dachun , Hasvold Lisa , Uziel Tamar , Lu Xin , Kohlhapp Fred , Fang Guowei , Elmore Steven W. , Rosenberg Saul H. , McDaniel Keith F. , Kati Warren M. , Shen Yu
Published: April 2023

Apoptosis induction by ABBV-075 across cancer cell lines
Figure S4 from β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy
Authors: Bucsek Mark J. , Qiao Guanxi , MacDonald Cameron R. , Giridharan Thejaswini , Evans Lauren , Niedzwecki Brian , Liu Haichao , Kokolus Kathleen M. , Eng Jason W.-L. , Messmer Michelle N. , Attwood Kristopher , Abrams Scott I. , Hylander Bonnie L. , Repasky Elizabeth A.
Published: April 2023

This figures shows that at endpoint, the MDSC burden is significantly reduced in 4T1 tumor-bearing mice treated with propranolol compared with PBS controls.
Figure S1 from β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy
Authors: Bucsek Mark J. , Qiao Guanxi , MacDonald Cameron R. , Giridharan Thejaswini , Evans Lauren , Niedzwecki Brian , Liu Haichao , Kokolus Kathleen M. , Eng Jason W.-L. , Messmer Michelle N. , Attwood Kristopher , Abrams Scott I. , Hylander Bonnie L. , Repasky Elizabeth A.
Published: April 2023

This figure shows that CD4+ depletion does not influence the effects of propranolol, unlike CD8+ depletion, supporting the fact that our observations are CD8+ T cell dependent.
Figure S3 from Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Authors: Wang Li-Ting , Chiou Shyh-Shin , Chai Chee-Yin , Hsi Edward , Yokoyama Kazunari K. , Wang Shen-Nien , Huang Shau-Ku , Hsu Shih-Hsien
Published: April 2023

Figure S3, A, Western blotting analysis of ISX, IDO1, TDO2, KYNU, and CYP1B1proteins in hepatocytes of AhR-null mice with treated proinflammatory cytokine IL-6 (10 ng/ml) B, The levels of kynurenine in hepatocytes of AHR+/+, AHR+/â^'and AHR-/â^' mice were determined by ELISA. C, Western blotting analysis of ISX, IDO1 and TDO2 proteins in tumors of mice transplanted with AHR or ISX-knockdown cells. D, Hepatoma cell (Huh 7) transfected with ISX-GFP showed to increase the concentration of kynurenine and PD-L1 in the culture medium when co-cultured with cytotoxic CD8+ T cells (1x104). The opposite effect was observed when Huh 7 cells transfected with ISX-specific shRNAi. E, ISX expression in Huh 7 cells significantly suppressed the proliferation of cytotoxic CD8+ T cells induced by anti-CD3 antibody. F, Huh 7 cells (1x104) overexpressing ISX-GFP significantly abolished cell apoptotic activity of spleen cytotoxic CD8+ T cell and the opposite effects were observed when Huh 7 cells were treated with anti-PD-1 monoclonal antibody or IDO inhibitor (INCB-024360). G, Huh 7 cells (1x104) overexpressing ISX-GFP significantly abolished cell apoptotic activity induced by co-cultured spleen cytotoxic CD8+ T cell and the opposite effects were observed when Huh 7 cells were treated with anti-PD-1 monoclonal antibody or IDO inhibitor (INCB-024360). a, p<0.001.
Supplemental figure 13 from Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies
Authors: Bui Mai H. , Lin Xiaoyu , Albert Daniel H. , Li Leiming , Lam Lloyd T. , Faivre Emily J. , Warder Scott E. , Huang Xiaoli , Wilcox Denise , Donawho Cherrie K. , Sheppard George S. , Wang Le , Fidanze Steve , Pratt John K. , Liu Dachun , Hasvold Lisa , Uziel Tamar , Lu Xin , Kohlhapp Fred , Fang Guowei , Elmore Steven W. , Rosenberg Saul H. , McDaniel Keith F. , Kati Warren M. , Shen Yu
Published: April 2023

Restoration of Myc expression under BET inhibitor treatment failed to rescue cells from apoptosis or cell cycle arrest
Figure S1 from Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Authors: Wang Li-Ting , Chiou Shyh-Shin , Chai Chee-Yin , Hsi Edward , Yokoyama Kazunari K. , Wang Shen-Nien , Huang Shau-Ku , Hsu Shih-Hsien
Published: April 2023

Figure S1. ISX activated transcription of IDOs, AHR, CD86, and PD-L1 in hepatoma cells by binding to the promoter region. a, p < 0.001. A, ISX transcriptionally activated luciferase activity driven by IDO1, TDO2 B, PD-L1 and CD86 C, and AHR D, promoter in Huh7 and SK-Hep1 cells. Indicated deletion luciferase mutants were constructed as described in the Materials and Methods. E, ChIP analysis of ISX''s binding to the promoters of IDO1, TDO2 and AHR in SK-Hep1 cells as described in Supplemental Materials and Methods. a, p<0.001, by comparing different experimental conditions as indicated by lines across various groups. F, ChIP analysis of ISX''s binding to the promoters of CD86 and PD-L1 in SK-Hep1 cells. p<0.001
Supplemental figure 1 from Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies
Authors: Bui Mai H. , Lin Xiaoyu , Albert Daniel H. , Li Leiming , Lam Lloyd T. , Faivre Emily J. , Warder Scott E. , Huang Xiaoli , Wilcox Denise , Donawho Cherrie K. , Sheppard George S. , Wang Le , Fidanze Steve , Pratt John K. , Liu Dachun , Hasvold Lisa , Uziel Tamar , Lu Xin , Kohlhapp Fred , Fang Guowei , Elmore Steven W. , Rosenberg Saul H. , McDaniel Keith F. , Kati Warren M. , Shen Yu
Published: April 2023

BRD4 binding to Myc regulatory region
Supplementary Fig. 6 from HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas
Authors: Sun Mianen , Tong Pan , Kong Wen , Dong Baijun , Huang Yiran , Park In Young , Zhou Lijun , Liu Xian-De , Ding Zhiyong , Zhang Xuesong , Bai Shanshan , German Peter , Powell Reid , Wang Quan , Tong Xuefei , Tannir Nizar M. , Matin Surena F. , Rathmell W. Kimryn , Fuller Gregory N. , McCutcheon Ian E. , Walker Cheryl L. , Wang Jing , Jonasch Eric
Published: April 2023

Working model.
Table S2 from Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells
Authors: Rohira Aarti D. , Yan Fei , Wang Lei , Wang Jin , Zhou Suoling , Lu Andrew , Yu Yang , Xu Jianming , Lonard David M. , O'Malley Bert W.
Published: April 2023

Table S2 lists the primer sequences used for amplification in ChIP qPCR
Table S1 from Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells
Authors: Rohira Aarti D. , Yan Fei , Wang Lei , Wang Jin , Zhou Suoling , Lu Andrew , Yu Yang , Xu Jianming , Lonard David M. , O'Malley Bert W.
Published: April 2023

Table S1 lists the primer sequences used for qPCR
Supplementary figures from STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway
Authors: Jin Lin , Vu Trung , Yuan Guandou , Datta Pran K.
Published: April 2023

This file contains six figures where the data implicated that silencing STRAP sensitized CRC cells to drug and diminished the subpopulation of CSC by epigenetically regulating NOTCH signals.
Supplementary Tables from STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway
Authors: Jin Lin , Vu Trung , Yuan Guandou , Datta Pran K.
Published: April 2023

This file includes two lists of primers for qPCR and ChIP. Other two tables support Figure 4.
Supplementary Table 1 from Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint
Authors: Green Abby M. , Budagyan Konstantin , Hayer Katharina E. , Reed Morgann A. , Savani Milan R. , Wertheim Gerald B. , Weitzman Matthew D.
Published: April 2023

Raw data and analysis of RNA-sequencing and qPCR evaluation of APOBEC3 expression in AML.
Figure S1 from Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription
Authors: Jin Ke , Zhou Wen , Han Xiaoqing , Wang Zhiqiang , Li Bin , Jeffries Shawn , Tao Wensi , Robbins David J. , Capobianco Anthony J.
Published: April 2023

p300 is required for NACK localization on the HES1 promoter, but not for Notch1 and Maml1 occupancy
Supplementary Table 1 from MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway
Authors: Tripathi Satyendra C. , Fahrmann Johannes F. , Celiktas Muge , Aguilar Mitzi , Marini Kieren D. , Jolly Mohit K. , Katayama Hiroyuki , Wang Hong , Murage Eunice N. , Dennison Jennifer B. , Watkins D. Neil , Levine Herbert , Ostrin Edwin J. , Taguchi Ayumu , Hanash Samir M.
Published: April 2023

Proteins identified in Total Cell Extract (TCE) and on Surface by mass spectrometery in SCLC cell lines using 5% and 1% FDR.
Table S4. from Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells
Authors: Zarei Mahsa , Lal Shruti , Parker Seth J. , Nevler Avinoam , Vaziri-Gohar Ali , Dukleska Katerina , Mambelli-Lisboa Nicole C. , Moffat Cynthia , Blanco Fernando F. , Chand Saswati N. , Jimbo Masaya , Cozzitorto Joseph A. , Jiang Wei , Yeo Charles J. , Londin Eric R. , Seifert Erin L. , Metallo Christian M. , Brody Jonathan R. , Winter Jordan M.
Published: April 2023

Table S4. List of Enzymes directly involved in the anti-oxidant defense response.
Supplementary Data and Methods from Modulation of Bax and mTOR for Cancer Therapeutics
Authors: Li Rui , Ding Chunyong , Zhang Jun , Xie Maohua , Park Dongkyoo , Ding Ye , Chen Guo , Zhang Guojing , Gilbert-Ross Melissa , Zhou Wei , Marcus Adam I. , Sun Shi-Yong , Chen Zhuo G. , Sica Gabriel L. , Ramalingam Suresh S. , Magis Andrew T. , Fu Haian , Khuri Fadlo R. , Curran Walter J. , Owonikoko Taofeek K. , Shin Dong M. , Zhou Jia , Deng Xingming
Published: April 2023

Figure S1. Bak BH3 peptide position in Bak protein. Figure S2. Dephosphorylation of Bax by lambdaPPase in vitro. Figure S3. Bax activators CYD-2-11 and SMBA1 failed to induce Bak oligomerization. Figure S4. Analysis of CYD-2-11 toxicity in vivo. Figure S5. CYD-2-11 has no significant effect on total Bax expression in SCLC PDX models. Figure S6. Toxicity analysis of CYD-2-11 in 2 PDX models. Figure S7. Bax phosphorylation is up-regulated in KRAS driven lung cancer. Figure S8. Quantification of tumor burden. Figure S9. H&E staining of normal tissues from various organs after CYD-2-11 treatment of KL mice. Figure S10. The dual PI3K/mTOR inhibitor BEZ235 inhibits ATK activity leading to down-regulation of Bax phosphorylation. Figure S11. CYD-2-11 synergizes with RAD001 to reverse rapalog resistance of lung cancer cells. Figure S12. RAD001 and CYD-2-11 did not affect total Bax in A549 xenografts. Figure S13. Toxicity analysis following treatment with RAD001, CYD-2-11 or in combination in A549 xenografts. Figure S14. CYD-2-11 synergizes with RAD001 against lung cancer in PDX model.
Table S1. from Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells
Authors: Zarei Mahsa , Lal Shruti , Parker Seth J. , Nevler Avinoam , Vaziri-Gohar Ali , Dukleska Katerina , Mambelli-Lisboa Nicole C. , Moffat Cynthia , Blanco Fernando F. , Chand Saswati N. , Jimbo Masaya , Cozzitorto Joseph A. , Jiang Wei , Yeo Charles J. , Londin Eric R. , Seifert Erin L. , Metallo Christian M. , Brody Jonathan R. , Winter Jordan M.
Published: April 2023

Table S1: Nomenclature used throughout manuscript to describe genetically modified cell lines.
Supplemental Information from Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells
Authors: Zarei Mahsa , Lal Shruti , Parker Seth J. , Nevler Avinoam , Vaziri-Gohar Ali , Dukleska Katerina , Mambelli-Lisboa Nicole C. , Moffat Cynthia , Blanco Fernando F. , Chand Saswati N. , Jimbo Masaya , Cozzitorto Joseph A. , Jiang Wei , Yeo Charles J. , Londin Eric R. , Seifert Erin L. , Metallo Christian M. , Brody Jonathan R. , Winter Jordan M.
Published: April 2023

Supplemental Methods and Supplemental Figure Legends
Supplementary Table S4 from Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6
Authors: Choudhury Atish D. , Schinzel Anna C. , Cotter Maura B. , Lis Rosina T. , Labella Katherine , Lock Ying Jie , Izzo Francesca , Guney Isil , Bowden Michaela , Li Yvonne Y. , Patel Jinal , Hartman Emily , Carr Steven A. , Schenone Monica , Jaffe Jacob D. , Kantoff Philip W. , Hammerman Peter S. , Hahn William C.
Published: April 2023

Genes downregulated by castration and upregulated by NEK6 expression in vivo.
Supplementary Table S2 from A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer
Authors: Kloosterman Wigard P. , Coebergh van den Braak Robert R.J. , Pieterse Mark , van Roosmalen Markus J. , Sieuwerts Anieta M. , Stangl Christina , Brunekreef Ronne , Lalmahomed Zarina S. , Ooft Salo , van Galen Anne , Smid Marcel , Lefebvre Armel , Zwartkruis Fried , Martens John W.M. , Foekens John A. , Biermann Katharina , Koudijs Marco J. , Ijzermans Jan N.M. , Voest Emile E.
Published: April 2023

Annotated list of predicted gene fusions that passed all filtering steps.
Supplementary Table 3 from Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer
Authors: Wali Vikram B. , Langdon Casey G. , Held Matthew A. , Platt James T. , Patwardhan Gauri A. , Safonov Anton , Aktas Bilge , Pusztai Lajos , Stern David F. , Hatzis Christos
Published: April 2023

List of direct and indirect targets of agents from each drug category.
Conflict of Interest Form from MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma
Authors: Lu Xinyuan , Peled Nir , Greer John , Wu Wei , Choi Peter , Berger Alice H. , Wong Sergio , Jen Kuang-Yu , Seo Youngho , Hann Byron , Brooks Angela , Meyerson Matthew , Collisson Eric A.
Published: April 2023

Conflict of Interest Form
Tables S1-4, Figures S1-6 from Utility of Genomic Analysis In Circulating Tumor DNA from Patients with Carcinoma of Unknown Primary
Authors: Kato Shumei , Krishnamurthy Nithya , Banks Kimberly C. , De Pradip , Williams Kirstin , Williams Casey , Leyland-Jones Brian , Lippman Scott M. , Lanman Richard B. , Kurzrock Razelle
Published: April 2023

Supplementary data: Supplemental Table 1. 54-70 gene panels. Supplemental Table 2. Genomic alterations in patients with carcinoma of unknown primary (N = 442) Supplemental Table 3. Summary of examples of possible cognate targeted therapies and relevant references. Supplemental Table 4. Complete list of genetic alterations found in 442 patients with carcinoma of unknown primary. Supplemental Figure 1. Frequency distribution of somatic SNVs and germline SNPs. Supplemental Figure 2. Oncoprint of 442 patients with carcinoma of unknown primary Supplemental Figure 3. Analysis of potentially actionable genomic alterations among 442 patients with carcinoma of unknown primary. Supplemental Figure 4. Number of characterized genomic alterations and number of potentially actionable genomic alterations per patient. Supplemental Figure 5. Fraction of ctDNA among frequently altered genes in patients with carcinoma of unknown primary. Supplemental Figure 6. Comparison of molecular alterations between current report using ctDNA and previous reports using tumor tissues from CUP patients.
Supplementary Tables and Figures from Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors
Authors: Miao Lei , Liu Qi , Lin C. Michael , Luo Cong , Wang Yuhua , Liu Lina , Yin Weiyan , Hu Shihao , Kim William Y. , Huang Leaf
Published: April 2023

Supplementary Table S1. Antibodies Used in the Study Supplementary Table S2. Characterization of LPD NPs Supplementary Table S3. Primers Used in the Study Supplementary Table S4. Blood Chemistry after Treatments Supplementary Figure S1. Morphology and in vivo biodistribution of LPD NPs. Supplementary Figure S2. Histology (H&E, left; IF, right; adjacent sections) of mice bearing UMUC3/3T3 tumors. Supplementary Figure S3. Calculation of DiI positive cells in each cell population within UMUC/3T3 xenograft tumors by flow cytometry (n=4). Supplementary Figure S4. In vitro transfection efficiency of sTRAIL or TRAIL loaded LPD on UMUC3 bladder cancer cell line. Supplementary Figure S5. Neighboring tumor-suppressive effect of the secreted TRAIL protein. Supplementary Figure S6. qPCR quantitation of relative mRNA levels of sTRAIL in the UMUC3/3T3 tumors after different treatments. Supplementary Figure S7. ELISA quantification of the expression and secretion of sTRAIL protein in the UMUC3/3T3 tumors after different treatments. Supplementary Figure S8. Collagen remodeling during the dose escalation of sTRAIL LPD. Supplementary Figure S9. Remodeling of tumor microenvironment after sTRAIL LPD treatment. Supplementary Figure S10. Histology (both fibroblast staining and collagen staining) of orthotopic BXPC3-Luc2 mouse xenograft. Supplementary Figure S11. sTRAIL LPD inhibited the metastasis of BXPC3-Luc2 tumors Supplementary Figure S12. Expression of GFP within different cell populations of BXPC3-Luc2 tumors after 3 doses of sTRAIL or TRAIL NPs (co-expressing GFP). Supplementary Figure S13. Collagen staining of tumors from mice treated with PBS and sTRAIL LPD NP, respectively. Supplementary Figure S14. In vivo cytotoxicity evaluation and organ distribution of sTRAIL or TRAIL LPD. Supplementary Figure S15. Apoptosis of neighboring tumor cells reduces the activation of fibroblasts.
Table S2 from Restoration of Natural Killer Cell Antimetastatic Activity by IL12 and Checkpoint Blockade
Authors: Ohs Isabel , Ducimetière Laura , Marinho Joana , Kulig Paulina , Becher Burkhard , Tugues Sonia
Published: April 2023

Expression levels of immune-regulatory genes in lung NK cells isolated from Ctrl- or IL-12-treated mice
Supplemental Figures from SMYD5 Controls Heterochromatin and Chromosome Integrity during Embryonic Stem Cell Differentiation
Authors: Kidder Benjamin L. , He Runsheng , Wangsa Darawalee , Padilla-Nash Hesed M. , Bernardo M. Margarida , Sheng Shijie , Ried Thomas , Zhao Keji
Published: April 2023

Figure S1. Altered differentiation and formation of transformed cells during EB formation of SMYD5 depleted ES cells Figure S2. LTR and LINE repeats are enriched at CNA regions in shSmyd5 cancer cells Figure S3. Expression of G9a in SMYD5-depleted ES cells and embryoid bodies. Figure S4. Expression of ERVK and L1 repeat subfamilies in shSmyd5 cancer cells Figure S5. Depletion of SMYD5 in human ES cells leads to transformation during differentiation Figure S6. SMYD5-depleted MCF10A cells exhibit altered 3D growth characteristics Figure S7. Depletion of SMYD5 leads to altered gene expression of breast cancer cells
Supplemental Table S1 from PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1
Authors: Lacey Alexandra , Rodrigues-Hoffman Aline , Safe Stephen
Published: April 2023

Antibodies, oligonucleotides and primers.
Supplementary Table 4 from New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
Authors: Wilson Leah J. , Linley Adam , Hammond Dean E. , Hood Fiona E. , Coulson Judy M. , MacEwan David J. , Ross Sarah J. , Slupsky Joseph R. , Smith Paul D. , Eyers Patrick A. , Prior Ian A.
Published: April 2023

Kinome copy number alterations and mutation frequency in cancer.
Supplementary Table 2 from New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
Authors: Wilson Leah J. , Linley Adam , Hammond Dean E. , Hood Fiona E. , Coulson Judy M. , MacEwan David J. , Ross Sarah J. , Slupsky Joseph R. , Smith Paul D. , Eyers Patrick A. , Prior Ian A.
Published: April 2023

Kinome responses to FDA approved kinase inhibitors
Supplementary figures S1 to S10 from Genetic Manipulation of Helicobacter pylori Virulence Function by Host Carcinogenic Phenotypes
Authors: Suarez Giovanni , Romero-Gallo Judith , Sierra Johanna C. , Piazuelo M. Blanca , Krishna Uma S. , Gomez Martin A. , Wilson Keith T. , Peek Richard M.
Published: April 2023

Supplemental Western blot analysis, cagY and cagPAI RFLPs, cagPAI sequence alignment, and strains nomenclature.
Fig S6 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Authors: Bakst Richard L. , Xiong Huizhong , Chen Chun-Hao , Deborde Sylvie , Lyubchik Anna , Zhou Yi , He Shizhi , McNamara William , Lee Sei-Young , Olson Oakley C. , Leiner Ingrid M. , Marcadis Andrea R. , Keith James W. , Al-Ahmadie Hikmat A. , Katabi Nora , Gil Ziv , Vakiani Efsevia , Joyce Johanna A. , Pamer Eric , Wong Richard J.
Published: April 2023

CCL3 ELISA performed on nerve lysates.
Fig S1 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Authors: Bakst Richard L. , Xiong Huizhong , Chen Chun-Hao , Deborde Sylvie , Lyubchik Anna , Zhou Yi , He Shizhi , McNamara William , Lee Sei-Young , Olson Oakley C. , Leiner Ingrid M. , Marcadis Andrea R. , Keith James W. , Al-Ahmadie Hikmat A. , Katabi Nora , Gil Ziv , Vakiani Efsevia , Joyce Johanna A. , Pamer Eric , Wong Richard J.
Published: April 2023

Nerve mediated inflammatory monocyte recruitment in perineural invasion.
Supplementary Figure Legends from Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition
Authors: Yaeger Rona , Yao Zhan , Hyman David M. , Hechtman Jaclyn F. , Vakiani Efsevia , Zhao HuiYong , Su Wenjing , Wang Lu , Joelson Andrew , Cercek Andrea , Baselga Jose , de Stanchina Elisa , Saltz Leonard , Berger Michael F. , Solit David B. , Rosen Neal
Published: April 2023

Supplementary Figure Legends: Supplementary Figure 1 - validation and characterization of acquired genomic alterations, Supplementary Figure 2 - RAS amplification leads to increased RAS-GTP and dimerization of RAF, Supplementary Figure 3 - Increase in NRAS expression is sufficient to cause resistance to RAF/EGFR inhibition in vitro in CRC, Supplementary Figure 4 - Increase in NRAS expression does not cause resistance to RAF inhibition in melanoma, Supplementary Figure 5 - Combined EGFR and RAF dimer inhibitors lead to better inhibition of signaling and tumor growth than RAF dimer inhibitor alone in BRAF V600E CRC.
Supplementary data legends from Cervical Cancer Growth Is Regulated by a c-ABL–PLK1 Signaling Axis
Authors: Yang Xu , Chen Gang , Li Wei , Peng Changmin , Zhu Yue , Yang Xiaoming , Li Teng , Cao Cheng , Pei Huadong
Published: April 2023

Supplementary data legends
Supplementary Figure S1. Identification of Protein Interaction Regions of PLK1 and c-ABL. from Cervical Cancer Growth Is Regulated by a c-ABL–PLK1 Signaling Axis
Authors: Yang Xu , Chen Gang , Li Wei , Peng Changmin , Zhu Yue , Yang Xiaoming , Li Teng , Cao Cheng , Pei Huadong
Published: April 2023

A, GST pull-down assay of PBD domain with c-ABL. Both input and pull-down samples were subjected to immunoblotting. B-C, Mapping the regions of c-ABL required for PLK1 binding. Indicated mutants (SH2, SH3 or PTKs) of c-ABL were used in GST-pull down assays.
Supplementary Table S1 from Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve–Dependent Regulation of NKG2D and CCR5
Authors: Song Yanfang , Gan Yu , Wang Qing , Meng Zihong , Li Guohua , Shen Yuling , Wu Yufeng , Li Peiying , Yao Ming , Gu Jianren , Tu Hong
Published: April 2023

Primers used in quantitative real-time PCR analysis.
Supplementary Figure S6 from Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve–Dependent Regulation of NKG2D and CCR5
Authors: Song Yanfang , Gan Yu , Wang Qing , Meng Zihong , Li Guohua , Shen Yuling , Wu Yufeng , Li Peiying , Yao Ming , Gu Jianren , Tu Hong
Published: April 2023

EE decreases serum leptin levels in wild-type and Beige mice.
Figure S2 from Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer
Authors: Cejalvo Juan M. , Martínez de Dueñas Eduardo , Galván Patricia , García-Recio Susana , Burgués Gasión Octavio , Paré Laia , Antolín Silvia , Martinello Rosella , Blancas Isabel , Adamo Barbara , Guerrero-Zotano Ángel , Muñoz Montserrat , Nucíforo Paolo , Vidal María , Pérez Ramón M. , Chacón López-Muniz José I. , Caballero Rosalía , Peg Vicente , Carrasco Eva , Rojo Federico , Perou Charles M. , Cortés Javier , Adamo Vincenzo , Albanell Joan , Gomis Roger R. , Lluch Ana , Prat Aleix
Published: April 2023

Figure
Supplementary Figure S4 from Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion
Authors: Ohishi Tomokazu , Yoshida Haruka , Katori Masamichi , Migita Toshiro , Muramatsu Yukiko , Miyake Mao , Ishikawa Yuichi , Saiura Akio , Iemura Shun-ichiro , Natsume Tohru , Seimiya Hiroyuki
Published: April 2023

TNKS1BP1-CapZA2 interaction and effects of siRNAs on cell viability.
Supplemental Figures and Legends from HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells
Authors: Zhu Shan , Zhang Qiuhong , Sun Xiaofan , Zeh Herbert J. , Lotze Michael T. , Kang Rui , Tang Daolin
Published: April 2023

This file contains supplemental figures of clonogenic cell survival assay.
Supplementary Figure S2 from Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion
Authors: Ohishi Tomokazu , Yoshida Haruka , Katori Masamichi , Migita Toshiro , Muramatsu Yukiko , Miyake Mao , Ishikawa Yuichi , Saiura Akio , Iemura Shun-ichiro , Natsume Tohru , Seimiya Hiroyuki
Published: April 2023

TNKS1BP1 depletion induces cofilin phosphorylation in HTC75 cells.
Supplemental Information from Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases
Authors: Ross Michael H. , Esser Alison K. , Fox Gregory C. , Schmieder Anne H. , Yang Xiaoxia , Hu Grace , Pan Dipanjan , Su Xinming , Xu Yalin , Novack Deborah V. , Walsh Thomas , Colditz Graham A. , Lukaszewicz Gabriel H. , Cordell Elizabeth , Novack Joshua , Fitzpatrick James A. J. , Waning David L. , Mohammad Khalid S. , Guise Theresa A. , Lanza Gregory M. , Weilbaecher Katherine N.
Published: April 2023

Supplemental Figure Legends
Supplemental Figure S4 from Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases
Authors: Ross Michael H. , Esser Alison K. , Fox Gregory C. , Schmieder Anne H. , Yang Xiaoxia , Hu Grace , Pan Dipanjan , Su Xinming , Xu Yalin , Novack Deborah V. , Walsh Thomas , Colditz Graham A. , Lukaszewicz Gabriel H. , Cordell Elizabeth , Novack Joshua , Fitzpatrick James A. J. , Waning David L. , Mohammad Khalid S. , Guise Theresa A. , Lanza Gregory M. , Weilbaecher Katherine N.
Published: April 2023

Integrin avb3-­targeting ligand and micelle nanoparticle localization within tumor-­free bone
Supplementary Figure S7. HuR silencing enhances olaparib efficacy in PDA xenografts from Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Authors: Chand Saswati N. , Zarei Mahsa , Schiewer Matthew J. , Kamath Akshay R. , Romeo Carmella , Lal Shruti , Cozzitorto Joseph A. , Nevler Avinoam , Scolaro Laura , Londin Eric , Jiang Wei , Meisner-Kober Nicole , Pishvaian Michael J. , Knudsen Karen E. , Yeo Charles J. , Pascal John M. , Winter Jordan M. , Brody Jonathan R.
Published: April 2023

Doxycycline induction of HuR silencing in MIA PaCa-2 cells (sh290) downregulates PARG expression in vitro and tumor growth in vivo.
Supplementary Figure S1. HuR expression regulates sensitivity to PARPi in pancreatic cancer cells from Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Authors: Chand Saswati N. , Zarei Mahsa , Schiewer Matthew J. , Kamath Akshay R. , Romeo Carmella , Lal Shruti , Cozzitorto Joseph A. , Nevler Avinoam , Scolaro Laura , Londin Eric , Jiang Wei , Meisner-Kober Nicole , Pishvaian Michael J. , Knudsen Karen E. , Yeo Charles J. , Pascal John M. , Winter Jordan M. , Brody Jonathan R.
Published: April 2023

HuR expression regulates short-term cell survival and long-term anchorage-independent growth in PDA cells, irrespective of DDR proficiency. PARPi stress induces HuR translocation in a time-dependent manner.
Supplementary Figure S5 from FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4–GSK3β–Nrf2 Signaling
Authors: Teng Yong , Zhao Huakan , Gao Lixia , Zhang Wenfa , Shull Austin Y. , Shay Chloe
Published: April 2023

FGF19/FGFR4 axis is essential for the effects of H2O2 in HCC cells. (A, B) FGFR4 knockout (FGFR4 KO) and wildtype (WT) MHCC97L cells were treated with 50 ÃŽÂ¼M of H2O2 for 24 hours. Cell viability was determined by MTS assays (A), and cellular release of O2Ã¢Â,¬Â¢- was determined by electrochemical analysis (B). (C, D) FGFR4 knockout MHCC97L cells were transfected with empty vector (EV) or vector containing full-length of FGF19 (FGF19 O/E), followed by treatment with 1 ÃŽÂ¼M of TG for 24 hours. Cell viability was determined by MTS assays (C), and cellular release of O2Ã¢Â,¬Â¢- was determined by electrochemical analysis (D). *P<0.05, N.S. indicates no significant difference.
Supplementary Figure S4 from FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4–GSK3β–Nrf2 Signaling
Authors: Teng Yong , Zhao Huakan , Gao Lixia , Zhang Wenfa , Shull Austin Y. , Shay Chloe
Published: April 2023

High expression of FGF19 reduces the sensitivity of HCC cells to H2O2. (A, B) MHCC97L cells transfected with empty vector (EV) or vector containing full-length of FGF19 (FGF19 O/E) were treated with H2O2 for 24 hours. Cell viability was determined by MTS assays (A), and cellular release of O2Ã¢â,¬â¢- was determined by electrochemical analysis (B). (C, D) MHCC97H cells transfected with shRNA targeted against GFP (shNC) or FGF19 (shFGF19-1 and shFGF19-2) were treated with H2O2 for 24 hours. Cell viability was determined by MTS assays (C), and cellular release of O2Ã¢â,¬â¢- was determined by electrochemical analysis (D). *P<0.05, **P<0.01.
Supplementary Tables from CBX8 Exhibits Oncogenic Activity via AKT/β-Catenin Activation in Hepatocellular Carcinoma
Authors: Zhang Chris Zhiyi , Chen Shi-Lu , Wang Chun-Hua , He Yang-Fan , Yang Xia , Xie Dan , Yun Jing-Ping
Published: April 2023

Supplementary Tables contain the following contents: siRNA and primers (Table S1), antibodies (Table S2), correlation of CBX8 and clinical features (Table S3), multivariate analyses of CBX8 (Table S4), data of heatmap in Figure 6A (Table S5), prediction of targets of miR-365a-3p (Table S6), and microRNAs targeting CBX8 (Table S7).
Supplementary Table 1 from Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer
Authors: Goldstein Jonathan T. , Berger Ashton C. , Shih Juliann , Duke Fujiko F. , Furst Laura , Kwiatkowski David J. , Cherniack Andrew D. , Meyerson Matthew , Strathdee Craig A.
Published: April 2023

Chemical structures of compounds used in study
Supplemental Fig. 3 from Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains
Authors: Peng Hongzhuang , Prokop Jeremy , Karar Jayashree , Park Kyewon , Cao Li , Harbour J. William , Bowcock Anne M. , Malkowicz S. Bruce , Cheung Mitchell , Testa Joseph R. , Rauscher Frank J.
Published: April 2023

Introduced mutations in BAP1 that are predicted to disrupt the helix structure of the BAP1-ULD domain dramatically disassociate its binding to the ASXL2-AB box. The GST-UCH association assay was performed with highly purified recombinant ULD-WT, L-P, or F-P mutant proteins and/or ASXL2-AB box proteins.
Supplemental tables 4-5 from Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment
Authors: San Martin Rebeca , Pathak Ravi , Jain Antrix , Jung Sung Yun , Hilsenbeck Susan G. , Piña-Barba María C. , Sikora Andrew G. , Pienta Kenneth J. , Rowley David R.
Published: April 2023

Primer and siRNA sequences
Figure S3 from Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements
Authors: Seo Jae Ho , Agarwal Ekta , Bryant Kelly G. , Caino M. Cecilia , Kim Eui Tae , Kossenkov Andrew V. , Tang Hsin-Yao , Languino Lucia R. , Gabrilovich Dmitry I. , Cohen Andrew R. , Speicher David W. , Altieri Dario C.
Published: April 2023

SNPH ubiquitination in tumor chemotaxis and bioenergetics
Supplementary Table 2 from CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma
Authors: Ravindran Menon Dinoop , Luo Yuchun , Arcaroli John J. , Liu Sucai , KrishnanKutty Lekha Nair , Osborne Douglas G. , Li Yang , Samson Jenny Mae , Bagby Stacey , Tan Aik-Choon , Robinson William A. , Messersmith Wells A. , Fujita Mayumi
Published: April 2023

Nano String analysis data. Related to Figure 2
Table S1 from TIP: A Web Server for Resolving Tumor Immunophenotype Profiling
Authors: Xu Liwen , Deng Chunyu , Pang Bo , Zhang Xinxin , Liu Wei , Liao Gaoming , Yuan Huating , Cheng Peng , Li Feng , Long Zhilin , Yan Min , Zhao Tingting , Xiao Yun , Li Xia
Published: April 2023

Leukocyte signature matrix (LM14), including gene expression matrix and source data.
supplementary figure 6 from Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming
Authors: Sánchez-Paulete Alfonso R. , Teijeira Álvaro , Quetglas José I. , Rodríguez-Ruiz María E. , Sánchez-Arráez Álvaro , Labiano Sara , Etxeberria Iñaki , Azpilikueta Arantza , Bolaños Elixabet , Ballesteros-Briones María Cristina , Casares Noelia , Quezada Sergio A. , Berraondo Pedro , Sancho David , Smerdou Cristian , Melero Ignacio
Published: April 2023

Expression of immunomodulatory antibody targets on tumor infiltrating lymphocytes following SFV-XF treatment.
Supplementary Materials from Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy
Authors: Zhao Yang , Zhang Chenran , Gao Liquan , Yu Xinhe , Lai Jianhao , Lu Dehua , Bao Rui , Wang Yanpu , Jia Bing , Wang Fan , Liu Zhaofei
Published: April 2023

The Supplementary Materials file contains the following: 1) Supplementary Methods; 2) Supplementary Fig. S1: structure and characterizations of GO(HPPH)-PEG; 3) Supplementary Fig. S2: in vitro stability of GO(HPPH)-PEG; 4) Supplementary Fig. S3: singlet oxygen sensor green assay for free HPPH and GO(HPPH)-PEG; 5) Supplementary Fig. S4: in vivo NIRF imaging of free HPPH and GO(HPPH)-PEG; 6) Supplementary Fig. S5: in vivo PDT efficiency of free HPPH and GO(HPPH)-PEG; 7) Supplementary Fig. S6: in vivo NIRF imaging of 4T1 tumor-bearing mice after intratumoral injection of IRDye800-labeled F4/80+ macrophages; 8) Supplementary Fig. S7: ex vivo microdistribution analysis of CM-DiI-labeled F4/80+ macrophages in tumor tissues; 9) Supplementary Fig. S8: ex vivo NIRF imaging of GO(HPPH)-PEG; 10) Supplementary Fig. S9: flow cytometric analysis of integrin β6 for 4T1 tumor cells; 11) Supplementary Fig. S10: in vivo NIRF imaging of GO(HPPH)-PEG in control and CTX-treated 4T1 tumor-bearing mice; 12) Supplementary Fig. S11: immunofluorescence analysis of integrin β6 and F4/80 in 4T1 tumor tissues; 13) Supplementary Fig. S12: the synthetic scheme of IRDye800-αF4/80-Fab and 99mTc-αF4/80-Fab; 14) Supplementary Fig. S13: SDS-PAGE and in vitro NIRF imaging of IRDye800-αF4/80-Fab and αF4/80-Fab; 15) Supplementary Fig. S14: in vitro macrophage-specific binding of IRDye800-αF4/80-Fab; 16) Supplementary Fig. S15: in vivo specific targeting of IRDye800-αF4/80-Fab; 17) Supplementary Fig. S16: in vitro macrophage-specific binding of 99mTc-αF4/80-Fab.
Table S1 from Long Noncoding RNA AB074169 Inhibits Cell Proliferation via Modulation of KHSRP-Mediated CDKN1a Expression in Papillary Thyroid Carcinoma
Authors: Gou Qiheng , Gao Linbo , Nie Xinwen , Pu Wenchen , Zhu Jingqiang , Wang Yichao , Liu Xuesha , Tan Shuangyan , Zhou Jian-Kang , Gong Yanqiu , He Juan , Wu Ke , Xie Yuxin , Zhao Wanjun , Dai Lunzhi , Liu Lunxu , Xiang Rong , Wei Yu-Quan , Zhang Lin , Peng Yong
Published: April 2023

primer and oligo sequences
Figure S1-S4 from Long Noncoding RNA AB074169 Inhibits Cell Proliferation via Modulation of KHSRP-Mediated CDKN1a Expression in Papillary Thyroid Carcinoma
Authors: Gou Qiheng , Gao Linbo , Nie Xinwen , Pu Wenchen , Zhu Jingqiang , Wang Yichao , Liu Xuesha , Tan Shuangyan , Zhou Jian-Kang , Gong Yanqiu , He Juan , Wu Ke , Xie Yuxin , Zhao Wanjun , Dai Lunzhi , Liu Lunxu , Xiang Rong , Wei Yu-Quan , Zhang Lin , Peng Yong
Published: April 2023

Supplementary figures and lncAB sequences