bluuebunny/crossref_metadata_2025 huggingface dataset:
The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes
Authors: Das Rickta Rani , Rahman Md. Atiar , Al-Araby Salahuddin Qader , Islam Md. Shahidul , Rashid Md. Mamunur , Babteen Nouf Abubakr , Alnajeebi Afnan M. , Alharbi Hend Faisal H. , Jeandet Philippe , Rafi Md. Khalid Juhani , Siddique Tanvir Ahmed , Uddin Md. Nazim , Zakaria Zainul Amiruddin
Published: July 2021

The purpose of this study was to look into the effects of green coconut mesocarp juice extract (CMJE) on diabetes‐related problems in streptozotocin‐ (STZ‐) induced type 2 diabetes, as well as the antioxidative functions of its natural compounds in regulating the associated genes and biochemical markers. CMJE’s antioxidative properties were evaluated by the standard antioxidant assays of 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), superoxide radical, nitric oxide, and ferrous ions along with the total phenolic and flavonoids content. The α‐amylase inhibitory effect was measured by an established method. The antidiabetic effect of CMJE was assayed by fructose‐fed STZ‐induced diabetic models in albino rats. The obtained results were verified by bioinformatics‐based network pharmacological tools: STITCH, STRING, GSEA, and Cytoscape plugin cytoHubba bioinformatics tools. The results showed that GC‐MS‐characterized compounds from CMJE displayed a very promising antioxidative potential. In an animal model study, CMJE significantly (P < 0.05) decreased blood glucose, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, uric acid, and lipid levels and increased glucose tolerance as well as glucose homeostasis (HOMA‐IR and HOMA‐b scores). The animal’s body weights and relative organ weights were found to be partially restored. Tissue architectures of the pancreas and the kidney were remarkably improved by low doses of CMJE. Compound‐protein interactions showed that thymine, catechol, and 5‐hydroxymethylfurfural of CMJE interacted with 84 target proteins. Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes‐related kidney disease. The data demonstrate the highly prospective use of CMJE in the regulation of tubulointerstitial tissues of patients with diabetic nephropathy.
Fuzzy Clustering Algorithm-Segmented MRI Images in Analysis of Effects of Mental Imagery on Neurorehabilitation of Stroke Patients
Authors: Su Haoliang , Wang Fang , Zhang Leying , Li Guiyang
Published: July 2021

The study focused on the automatic segmentation of Magnetic Resonance Imaging (MRI) images of stroke patients and the therapeutic effects of Mental Imagery on motor and neurological functions after stroke. First, the traditional fuzzy c-means (FCM) algorithm was optimized, and the optimized one was defined as filter-based FCM (FBFCM). 62 stroke patients were selected as the research subjects and randomly divided into the experimental group and the control group. The control group accepted the conventional rehabilitation training, and the experimental group accepted Mental Imagery on the basis of the control group. They all had the MRI examination, and their brain MRI images were segmented by the FBFCM algorithm. The MRI images before and after treatment were analyzed to evaluate the therapeutic effects of Mental Imagery on patients with motor and nerve dysfunction after stroke. The results showed that the segmentation coefficient of the FBFCM algorithm was 0.9315 and the segmentation entropy was 0.1098, which were significantly different from those of the traditional fuzzy c-means (FCM) algorithm. (

P
<
0.05

), suggesting that the FBFCM algorithm had good segmentation effects on brain MRI images of stroke patients. After Mental Imagery, it was found that the patient’s Function Independent Measure (FIM) score was 99.04 ± 8.19, the Modified Barthel Index (MBI) score was 51.29 ± 4.35, the Fugl-Meyer (FMA) score was 61.01 ± 4.16, the neurological deficit degree in stroke (NFDS) score was 11.48 ± 2.01, the NIH Stroke Scale (NIHSS) score was 10.36 ± 1.69, and the clinical effective rate was 87.1%, all significantly different from those of the conventional rehabilitation training group (

P
<
0.05

). Additionally, the brain area activated by Mental Imagery was more extensive. In conclusion, the FBFCM algorithm demonstrates superb capabilities in segmenting MRI images of stroke patients and is worth promotion in clinic. Mental Imagery can promote the neurological rehabilitation of patients by activating relevant brain areas of patients.
Substituted-Amidine Functionalized Monocyclic β-Lactams: Synthesis and In Vitro Antibacterial Profile
Authors: He Lili , Zhai Lijuan , Sun Jian , Ji Jingwen , Ji Jinbo , Liu Yuanbai , Mu Yangxiu , Gao Yuanyu , Tang Dong , Jiang Rui , Myo Ko Ko , Thu Zaw Min , Yang Haikang , Iqbal Zafar , Yang Zhixiang
Published: July 2021

Background. Owing to the intrinsic stability against common β-lactamases and metallo-lactamases, monobactams gathered special attention in antibiotic drug development. However, so far, aztreonam is the only monobactam approved by FDA for clinical use. We designed new derivatives of aztreonam to enhance its antibacterial efficacy. Methods. We synthesized a series of monocyclic β-lactams by modifying mainly at the C3 position of azetidinone ring. NH2 group at C3 of azetidinone was attached to thiazole and thiadiazole which in turn was linked to nitrogenous heterocyclic rings via amidine moieties. We then investigated the in vitro antibacterial activities of synthesized compounds against ten bacterial strains of clinical interest in comparison to aztreonam and ceftazidime. Results. All compounds showed improved antibacterial activities against tested strains compared to reference drugs. Compounds 14d and 14e were most potent and showed the highest potency against all bacterial strains, with MIC values ranging from 0.25 µg/mL to 8 µg/mL, as compared to aztreonam (MIC 16 µg/mL to >64 µg/mL) and ceftazidime (MIC >64 µg/mL). These compounds (14d and 14e) may be valuable lead targets against multidrug-resistant Gram-negative bacteria.
The Effect of Virtual Reality Training on Anticipatory Postural Adjustments in Patients with Chronic Nonspecific Low Back Pain: A Preliminary Study
Authors: Li Zhicheng , Yu Qiuhua , Luo Haizhen , Liang Wenzhao , Li Xin , Ge Le , Zhang Siyun , Li Le , Wang Chuhuai
Published: July 2021

Objectives. This study is aimed at exploring the effects of virtual reality (VR) training on postural control, measured by anticipatory and compensatory postural adjustments (APAs and CPAs, respectively), in patients with chronic nonspecific low back pain (CNLBP) and the potential neuromuscular mechanism of VR training. Methods. Thirty-four patients were recruited and randomly assigned to the VR group (

n
=
11

), the motor control exercise group (MCE,

n
=
12

) and the control group (CG,

n
=
11

). The VR group received VR training using Kinect Xbox 360 systems and magnetic therapy. Besides magnetic therapy, the participants in the MCE group performed real-time ultrasound-guided abdominal drawing-in maneuver (ADIM) and four-point kneeling exercise. The CG only received magnetic therapy. Surface muscle electromyography (sEMG) was used to record the muscle activities of transverse abdominis (TrA), multifidus (MF), lateral gastrocnemius (LG), and tibialis anterior (TA) during ball-hitting tasks. The muscle activation time and integrals of the electromyography activities (IEMGs) during the APA and CPA stages were calculated and used in the data analysis. The visual analogue scale (VAS) and Oswestry dysfunction index (ODI) scores were also recorded. Results. A significant interaction effect of

time
×
group

was observed on the activation time of TrA (

p
=
0.018

) and MF (

p
=
0.037

). The post-intervention activation time of the TrA was earlier in the VR group (

p
=
0.029

). In contrast, the post-intervention activation time of the MF was significantly delayed in the VR group (

p
=
0.001

). The IEMGs of TrA (

p
=
0.002

) and TA (

p
=
0.007

) during CPA1 significantly decreased only in the VR group after the intervention. The VAS scores of three group participants showed significant decreases after intervention (

p
<
0.001

). Conclusions. Patients with CNLBP showed reciprocal muscle activation patterns of the TrA and MF muscles after VR training. VR training may be a potential intervention for enhancing the APAs of the patients with CNLBP.
IgA Nephropathy in a Patient Treated with Adalimumab
Authors: Mertelj Tonja , Smrekar Nataša , Kojc Nika , Lindič Jelka , Kovač Damjan
Published: July 2021

Immunoglobulin A (IgA) nephropathy (IgAN) is the most common glomerulonephritis worldwide, characterized by IgA deposits in the glomerular mesangium. It has a progressive nature and can eventually lead to end-stage kidney failure. It can occur as a potential side effect of treatment with tumor necrosis factor alpha antagonist that has been used for numerous chronic inflammatory conditions, such as Crohn’s disease. In this study, the case of a 33-year-old man with renal dysfunction, nephrotic proteinuria, and erythrocyturia is described. He had had a history of Crohn’s disease for 8 years and had been treated with adalimumab for the past 7 years. The diagnosis of IgAN was confirmed by kidney biopsy. After discontinuance of adalimumab and the induction of corticosteroid therapy, he made a remarkable recovery. Four years after the first presentation of IgAN and discontinuation of adalimumab, his renal function was normal with no proteinuria and only mild erythrocyturia.
Desmoplastic Small Round Cell Tumor of the Submandibular Gland: A Case Report and Literature Review
Authors: Li Qingjiao , Yuan Xiaolu
Published: July 2021

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressively malignant tumor mostly occurring in the abdominal and pelvic cavity of young patients. However, few cases had been reported concerning DSRCT occurring in the head and neck region. We presented a rare case of DSRCT of the right submandibular in a 25-year-old man. MRI revealed a 3 × 2-cm solid nodule located in the right submandibular, and physical examination showed no other occupying lesion elsewhere. Histologically, the tumor was composed of various-sized small round cell nests, embedded in an abundant desmoplastic stroma. Immunohistochemically, the tumor cells were typically positive for epithelial (CK and EMA), mesenchymal (vimentin and desmin), and neuroendocrine (CD56, NSE, Syn, and CgA) markers, but negative for WT1. Fluorescence in situ hybridization revealed the presence of a break apart involving the Ewing sarcoma (EWS) gene. The patient received chemotherapy and radiotherapy and relapsed after 19 months of follow-up. DSRCT of the submandibular gland is rare, and the diagnosis of this tumor in an uncommon location relies on the histomorphology, immunophenotype, and EWS gene translocation detection. Differential diagnosis including primary salivary gland tumors and the other small round cell tumors needs to be excluded.
Evaluation of the Fetal Therapy Evidence in Lower Urinary Tract Obstruction: Would an ERAS Guideline Improve Outcomes?
Authors: Wilson R. Douglas , Nelson Gregg
Published: July 2021

Background: Pregnancies that are prenatally identified to have fetal anomalies are complex and require expert multidisciplinary care. As many conditions can impact the fetus prenatally and require intervention, an enhanced recovery after surgery (ERAS) for lower urinary tract obstruction (LUTO) is being evaluated to determine the level of evidenced-based data available. Problem: The percutaneous ultrasound-guided fetal surgery procedure for bladder neck obstruction is the focus for elements of preoperative counseling, intraoperative procedure/risk complications, and postoperative management. Methods: A quality improvement review Squire 2.0 (2000–2020) was undertaken for the percutaneous LUTO fetal surgery shunting (lower urinary tract obstruction), process and procedure which require 2 process pathways, one to evaluate the fetal candidate and a second to treat. This structured review is focused on identifying the process elements to allow the determination of the number of evidenced-based elements that would allow for audit and measurement of the clinical element variance for comparative feedback to the individual surgical provider or surgery center. Interventions: Titles and abstracts were screened to identify potentially relevant articles with priority given to meta-analyses, systematic reviews, randomized controlled studies, nonrandomized controlled studies, reviews, and case series. Results: A series of potential clinical elements for the diagnostic fetal evaluation and for the 3 protocol areas of surgical care for the procedures (pre-, intra-, and postoperative care) are identified using an ERAS-like process. Conclusions: The identified clinical elements have the potential for ERAS-LUTO fetal therapy guideline. Multidisciplinary collaboration (surgeon, anesthesia, nursing, imaging, and laboratory) is required for ERAS quality improvement in the pre-, intra-, and postoperative processes. Process elements in each of the operative areas can be audited, evaluated, compared, and modified/improved.
EAU, AUA and NICE Guidelines on Surgical and Minimally Invasive Treatment of Benign Prostate Hyperplasia: A Critical Appraisal of the Guidelines Using the AGREE-II Tool
Authors: Enikeev Dmitry , Misrai Vincent , Rijo Enrique , Sukhanov Roman , Chinenov Denis , Gazimiev Magomed , Taratkin Mark , Azilgareeva Camilla , Morozov Andrey , Herrmann Thomas R.W. , Glybochko Petr
Published: July 2021

Objective: To critically appraise the methodological rigour of the clinical practice guidelines (CPGs) vis-à-vis BPH surgery as used by specialist research associations in the US, Europe and UK, and to compare whether the guidelines cover all or only some of the available treatments. Methods: The current guidelines issued by the EUA, AUA and NICE associations have been analyzed by 4 appraisers using the AGREE-II instrument. We also compared the recommendations given in the guidelines for surgical and minimally invasive treatment to find out which of these CPGs include most of the available treatment options. Results: According to the AGREE II tool, the median scores of domains were: domain 1 scope and purpose 66.7%, domain 2 stakeholder involvement 50.0%, domain 3 rigor of development 65.1%, domain 4 clarity of presentation 80.6%, domain 5 applicability 33.3%, domain 6 editorial independence 72.9%. The overall assessment according to AGREE II is 83.3%. The NICE guideline scored highest on 5 out of 6 domains and the highest overall assessment score (91.6%). The EAU guideline scored lowest on 4 out of 6 domains and has the lowest overall assessment score (79.1%). Conclusions: The analyzed CPGs comprehensively highlight the minimally invasive and surgical treatment options for BPH. According to the AGREE II tool, the domains for clarity of presentation and editorial independence received the highest scores. The stakeholder involvement and applicability domains were ranked as the lowest. Improving the CPG in these domains may help to improve the clinical utility and applicability of CPGs.
Long-Term Amnioinfusion through an Intrauterine Catheter in Preterm Premature Rupture of Membranes before 26 Weeks of Gestation: A Retrospective Multicenter Study
Authors: Goździewicz Tomasz , Rycel-Dziatosz Magdalena , Madziar Klaudyna , Szczapa Tomasz , Kędzia Witold , Szaflik Krzysztof
Published: July 2021

Introduction: The objective of this study was to elucidate the efficacy of long-term amnioinfusion on perinatal outcomes in patients with preterm premature rupture of membranes (PPROM) before 26 weeks’ gestation. Material: A total of 31 patients with PPROM at a periviable gestational age (21 + 0–25 + 0 weeks) were enrolled. Long-term amnioinfusion was performed in 22 patients, and 9 patients did not receive amnioinfusion. Data were collected retrospectively from 2 clinical sites between January 2017 and March 2019. Results: In the medical management group, there was a significantly higher rate of chorioamnionitis compared to the long-term amnioinfusion group (89 vs. 15%, p = 0.001). The latency period between PPROM and delivery was higher in the amnioinfusion group (median, 5.5 vs. 3 weeks, p = 0.04). The frequency of bronchopulmonary dysplasia was higher in the control group compared to the amnioinfusion group (89 vs. 40%, p = 0.03). The rates of other neonatal complications were similar in both groups. Conclusions: Long-term amnioinfusion through an intrauterine catheter in PPROM before 26 weeks’ gestation may improve pregnancy and newborn outcomes.
Isotretinoin Associated Rhabdomyolysis: Monitoring Creatine Kinase and Educating Patients
Authors: Fayiga Folasade F. , Reyes-Hadsall Sophia C. , Sebastiany Ludonir C. , Arutyunyan Sergey , Wong Alan , Duarte Ana M.
Published: July 2021

Monitoring specific values at baseline and throughout treatment is standard of care for isotretinoin therapy; however, creatine kinase (CK) blood monitoring is often excluded. Herein, we describe the importance of CK monitoring during isotretinoin therapy to assess the risk of rhabdomyolysis and potential renal damage, regardless of muscle-related symptom presentation. We present 2 patients with hyperCKemia: a 16-year-old male on isotretinoin whose CK levels were elevated (7,325 U/L) when rhabdomyolysis symptoms were present, and an asymptomatic 18-year-old male with elevated CK levels (35,000 U/L) before starting isotretinoin. Based on our experience, we strongly recommend obtaining CK levels to monitor for and potentially prevent rhabdomyolysis and its associated complications.
Comparative Efficacy and Acceptability of 3 Repetitive Transcranial Magnetic Stimulation Devices for Depression: A Meta-Analysis of Randomized, Sham-Controlled Trials
Authors: Matsuda Yuki , Yamazaki Ryuichi , Kishi Taro , Iwata Nakao , Shigeta Masahiro , Kito Shinsuke
Published: July 2021

Introduction: Repetitive transcranial magnetic stimulation (rTMS) has been employed worldwide for therapy-resistant depression. The Food and Drug Administration has approved a number of therapeutic devices for treating major depressive disorder; however, no studies have examined the differences in efficacy and acceptability among commercially available stimulation devices. The aim of our study was to compare the efficacy and acceptability of 3 stimulation devices (NeuroStar, MagPro, and Magstim) for depressive disorders. Methods: Our study included 31 randomized sham-controlled trials of high-frequency rTMS included in the network meta-analysis by Brunoni. We calculated the risk ratio and 95% confidence intervals, comparing each device with sham for the endpoints of response rate, remission rate, and all-cause discontinuation. We then analyzed the differences among the devices in effect size for those endpoints. Results: After determining the effect sizes for the endpoints, we found no statistically significant subgroup differences in the response rates, all-cause discontinuation, or remission rates among the devices (p = 0.12, p = 0.84, and p = 0.07, respectively). Conclusion: Our results suggest similar efficacy and acceptability for the 3 stimulation devices. Future studies need to perform head-to-head comparisons of the efficacy and acceptability of the stimulation devices for treating depression using the same stimulation protocols.
Challenges Encountered by Junior High School Graduates of the School of Tomorrow Program to Senior High School Program in Capiz: A Case Study
Authors: Panaligan Jan April , Maming Jimmy Bernabe
Published: July 2021

The School of Tomorrow (S.O.T.) having the Accelerated Christian Education (A.C.E.) here in the Philippines promises that they can give the most advanced twenty-first-century educational system available, but the experiences and grievances of S.O.T. graduates stated otherwise. This case study intends to determine the key informant's experiences in transitioning from Accelerated Christian Education (A.C.E.) institution to conventional schools in Capiz. This study utilized interviews, observation, and data reviews in gathering the data while the Mayring (2002) approach was utilized in analyzing the data. Themes came out from the constructs of the interviewees in Capiz, like S.O.T. curriculum is offered in Pre-School to Junior High School only, difficulty in transitioning from S.O.T. school to conventional schools offering Senior High School Program and conventional schools must be adopted and integrated to the S.O.T. Junior High School. The output of the research is the proposed new S.O.T. curriculum model to help address the existing problems.
Serological survey of leptospirosis, brucellosis, and lentivirus in herds of small ruminants in Recôncavo Baiano, Bahia, Brazil
Authors: Carvalho Rodrigo Rezende Mires de , Paz Lucas Nogueira , Dias Carla Silva , Nocera Giselle Almeida , Mesquita Augusto José Pereira de , Pinna Melissa Hanzen
Published: July 2021

A serological survey was carried out to assess the frequency of leptospirosis, small ruminants lentivirus (SRLV), and brucellosis in small ruminant herds in the Recôncavo Baiano, State of Bahia, Brazil, from February to December 2017. In four goat herds, 125 animals were tested for SRLV and leptospirosis, while in five sheep herds, 378 animals were tested for leptospirosis, brucellosis, and SRLV. Regarding leptospirosis, MAT detected 80% of goats and 15.34% of sheep seroreactive. Reactivity was most frequent to serogroups Autumnalis and Grippotyphosa in goats and sheep, respectively. Regarding SRLV, 8.8% of goats and 0.79% of sheep were reactive. Search for anti-B. ovis antibodies revealed 0.52% reactivity. In sheep, three animals showed simultaneous seroreactivity for SRLV and leptospirosis, while one animal had a serological response for brucellosis and leptospirosis. In goats, simultaneous seroreactivity for SRLV and leptospirosis was observed in only one animal. Leptospirosis was the most frequent of the three infectious diseases in investigated herds.
Ascensão, vertigem e queda: correspondências entre Limite e Mundéu
Authors: Novaes Bárbara Bergamaschi
Published: July 2021

Neste artigo traçamos as correspondências “plástico-verbais” entre as escritas poética e cinematográfica de Mário Peixoto (1908-1992), buscando pontos de contato entre essas duas linguagens. Através de um cotejamento entre a decupagem de três cenas do filme Limite e da escansão do poema “A grande curva”, publicado no livro Mundéu, acreditamos ser possível vislumbrar como a poesia e a mise-en-scène de Mário Peixoto obedecem a uma mesma lógica formal de construção. Para tal utilizamos estudos de Mário de Andrade, Paulo Henriques Britto, Flora Süssekind e alguns conceitos operativos da teoria da montagem de Sergei Eisenstein. Em uma via de mão dupla, demonstramos como Peixoto absorveu os debates de seu tempo, transfigurou sua poesia em cinema e, inversamente, como o cinema “enformou” seus poemas. A proposta é pensar a obra de Peixoto para além da teoria estritamente cinematográfica, nos centrando no profícuo intercâmbio entre o cinema, a teoria literária e os estudos da poesia.
Festivais de cinema pós-Covid-19: impactos e perspectivas
Authors: Cirino Nathan Nascimento , Canuto Kleyton Jorge
Published: July 2021

Diante da pandemia de Covid-19, diversos festivais de cinema no Brasil e no mundo tiveram que se adaptar à situação de distanciamento social, o que reconfigurou parte dos eventos para ambientes virtuais. A importância dos festivais como criadores de público e janelas de exibição para obras com menor alcance de distribuição pode estar iniciando um caminho de diferentes fruições para o audiovisual, mais alinhado com a internet, as novas mídias e o consumo individual e residencial. O presente estudo faz um levantamento nos níveis internacional, nacional e regional das adaptações dos festivais de cinema em 2020, apontando a partir daí os possíveis novos rumos do audiovisual.
La mujer sin cabeza: fluxos estéticos e políticos no cinema argentino
Authors: Fischer Sandra , Adams Natália Lago , Vaz Aline
Published: July 2021

O artigo, situado no campo dos estudos contemporâneos de cinema, problematiza questões relativas ao cinema de fluxo tomado da forma como se apresenta no filme La mujer sin cabeza (2008), de Lucrecia Martel. Para tanto, discute e analisa na obra as estratégias adotadas para a colocação em quadro do contexto sociopolítico da Argentina neoliberal pós-ditaduras, verifica os efeitos de sentido produzidos por meio das homologações entre o plano do conteúdo fílmico e o plano da expressão cinematográfica, e trata das consequentes articulações estéticas e estésicas. Considerando o cinema como privilegiado campo do sintoma da sociedade em que se se encontra cronotopicamente inserido, conclui-se que o filme em tela, ao focalizar as miudezas do cotidiano e suas modulações sensíveis, sinaliza a emergência de um suposto Nuevo Cine Argentino – que tanto viabiliza a detecção de angústias e asfixias sociais, quanto oportuniza, potencialmente, revisões de paradigmas e conceitos pré-estabelecidos.
A reinvenção intermidiática do cinema
Authors: Mello Cecília
Published: July 2021

O livro de Ágnes Pethő Cinema and intermediality: the passion for the in-between encara a questão da intermidialidade no cinema com surpreendente profundidade e erudição e, como tal, ilumina e abre novos caminhos na teoria do cinema e da mídia.
Contribuições piagetianas ao ensino de jornalismo
Authors: Ratier Rodrigo Pelegrini
Published: July 2021

El artículo tiene como objetivo presentar contribuciones del pensamiento de Jean Piaget a la enseñanza del periodismo. Se centra principalmente en la necesidad de una participación activa del estudiante en la construcción del conocimiento, según lo recomendado por las Directrices Curriculares Nacionales para el Curso de Periodismo (MEC / CNE, 2013). Aunque el investigador suizo no concibió un "método piagetiano", la aplicación de los preceptos de su teoría a la educación puede ofrecer posibles enfoques para los procesos de enseñanza y aprendizaje inspirados en el constructivismo. En este ensayo, se desarrolla un diálogo entre las Directrices Curriculares Nacionales y los modelos de enseñanza inspirados en Piaget propuestos por Gruber y Vonèche (1977) y actualizados por Macedo (2012).
Dos novos meios às novas mediações: o ensino remoto nos tempos da pandemia
Authors: Rial y Costas Gundo
Published: July 2021

Based on online teaching during the pandemic in Rio de Janeiro, we analyze the use of media and its mediations according to Martín-Barbero in two opposed parts of society. Firstly, and by looking through an educommunication lens with own ethnographic examples, we refer to teaching in the periphery and favelas of the city. In this context, we emphasize the students’ logistic and material problems of access to the new teaching platforms and with reading and understanding the didactic materials provided by the city council. The other side focusses on a private cultural institute by introducing advantages of online teaching, such as convivial solidarity, the virtual coming together of geographically separated people, the benefits of the online platform zoom and the learning about other cultures. In the conclusion we ask if and how these advantages can be reused for general benefit.
Cursos de Jornalismo em perspectiva histórico-geográfica: arranjos locais e regionais no Brasil
Authors: Moreira Sonia Virgínia , Pereira Antonia Alves
Published: July 2021

This paper analyzes the growth of journalism undergraduate courses in public and private universities and the geographic distribution of networks that are established among courses in many urban dimensions. It considers the regional insertions of the courses in different spaces, such as large, medium, and small cities according to the geographical concept of “hierarchy of the cities” formulated by the Brazilian Institute of Geography and Statistics, and on data gathered from the Brazilian Ministry of Education website. The data collected show that affirmative action policies, such as student financing, the unified selection system, and the entry of black and indigenous people and also persons with disabilities, increased the students’ flow between cities and regions. They also reveal that access to higher education contributed to the diversity and social inclusion of youths with low-income in small cities reaching the universities and journalism undergraduate courses.
Keywords: higher education; journalism undergraduate courses, geographic regions, scales; Brazil.
Contratos comunicativos no ensino formal e no jornalismo: uma análise comparativa entre agências socializadoras de conhecimentos
Authors: Meditsch Eduardo , Kronbauer Janaíne
Published: July 2021

This article adopts the perspective of Educommunication of emphasizing the increasing importance of the media as a knowledge socialization agency, parallel to the school, and the potential of the comparative method to elucidate similarities and differences between its gnoseological practices. For such purpose, it observes Formal Education and Journalism as communicational phenomena, and points out some similarities and divergences between the characteristics of both, considering the elements of the Communicative Contract as defined by Patrick Charaudeau. The results, although limited by the space and scope of the study, show the potential of unveiling the characteristics of the knowledge socialization agencies studied in the scope of Educommunication, when it dialogues, in its multidisciplinary perspective, with specialized areas of Communication, in this case, Journalism Studies.
Democratização das mídias e educação
Authors: Costa Maria Cristina Castilho
Published: July 2021

This text approaches the obstacles that prevent the general public from differentiating messages and information from the reality. For such purpose, we work with two basic ideas: on the one hand, the advances of democracy in the Western world and, on the other hand, the development of the media and the establishment of media society. We present the conflict between republican political mechanisms and freedom of speech, and between market interests and information. By historically analyzing different stages of these conflicts, this article proposes, in a globalized society connected by network communication, the fight for the democratization of the media as a way to free the public from Plato’s Cave of the contemporary world.
Explorações teóricas para pensar as inter-relações entre educomunicação e comunicação comunitária
Authors: Saggin Livia Freo , Bonin Jiani Adriana
Published: July 2021

The article explores and articulates the concepts of educommunication and community communication in the perspective of the practices of subjects that produce communication, based on the investigation of proposals by Brazilian and Latin American researchers considered relevant for the treatment of these concepts. The reflections undertaken have as horizon the concrete needs of a research that investigates the educommunicative processes developed in the production of the newspapers Boca de Rua and O Cidadão and their role in the construction of communicative citizenship. The proposals, studied in articulation, dialogue and confrontation with data from empirical explorations, are productive to understand the community educommunication processes developed by the communicating subjects in the investigated contexts.
Substrate Characterization and Outcomes of Ventricular Tachycardia Ablation in
TTN (Titin)
Cardiomyopathy
Authors: Enriquez Andres , Liang Jackson , Smietana Jeffrey , Muser Daniele , Salazar Pablo , Shah Rajan , Badhwar Nitish , Bogun Frank , Marchlinski Francis , Garcia Fermin , Baranchuk Adrian , Tung Roderick , Redfearn Damian , Santangeli Pasquale
Published: July 2021

Background:

Truncating variants of the
TTN
(
titin
) gene are a leading cause of dilated cardiomyopathy and have been associated with an increased risk of ventricular arrhythmias. This study evaluated the substrate distribution and the acute and long-term outcomes of patients with
TTN
-related cardiomyopathy undergoing ventricular tachycardia (VT) ablation.

Methods:

This multicenter registry included 15 patients with dilated cardiomyopathy (age, 59±11 years; 93% men; ejection fraction, 30±12%) and genotypically confirmed truncating variants of the
TTN
gene who underwent VT ablation between July 2014 and 2020.

Results:

All patients presented with sustained monomorphic VT, including electrical storm in 4 of them. A median of 2 VTs per patient were induced during the procedure (cycle length, 318±68 ms), and the predominant morphologies were left bundle branch block with inferior axis (39%) and right bundle branch block with inferior axis (29%). A complete map of the left ventricle was created in 12 patients and showed voltage abnormalities mainly at the periaortic (92%) and basal septal regions (58%). A preprocedural cardiac magnetic resonance imaging was available in 13 patients, and in 11, there was evidence of left ventricular delayed gadolinium enhancement, with predominantly midmyocardial distribution. Sequential ablation from both sides of the septum was required in 47% of patients to target septal intramural substrate, and epicardial ablation was performed in 20%. At the end of the procedure, the clinical VT was noninducible in all patients, while in 3 cases, a nonclinical VT was still inducible. After a follow-up of 26.5±23.0 months, 53% of patients experienced VT recurrence, 20% received transplant or mechanical circulatory support, and 7% died.

Conclusions:

The arrhythmogenic substrate in
TTN
-related cardiomyopathy involves the basal septal and perivalvular regions. Long-term outcomes of catheter ablation are modest, with high recurrence rate, likely related to an intramural location of VT circuits.
Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling
Authors: Mao Chenfeng , Ma Zihan , Jia Yiting , Li Weihao , Xie Nan , Zhao Guizhen , Ma Baihui , Yu Fang , Sun Jinpeng , Zhou Yuan , Cui Qinghua , Fu Yi , Kong Wei
Published: July 2021

Background:

How the extracellular matrix (ECM) microenvironment modulates the contractile phenotype of vascular smooth muscle cells (VSMCs) and confers vascular homeostasis remains elusive.

Methods:

To explore the key ECM proteins in the maintenance of the contractile phenotype of VSMCs, we applied protein-protein interaction network analysis to explore novel ECM proteins associated with the VSMC phenotype. By combining in vitro and in vivo genetic mice vascular injury models, we identified nidogen-2, a basement membrane glycoprotein, as a key ECM protein for maintenance of vascular smooth muscle cell identity.

Results:

We collected a VSMC phenotype–related gene dataset by using Gene Ontology annotation combined with a literature search. A computational analysis of protein-protein interactions between ECM protein genes and the genes from the VSMC phenotype–related gene dataset revealed the candidate gene nidogen-2, a basement membrane glycoprotein involved in regulation of the VSMC phenotype. Indeed, nidogen-2–deficient VSMCs exhibited loss of contractile phenotype in vitro, and compared with wild-type mice, nidogen-2
–/
–
mice showed aggravated post–wire injury neointima formation of carotid arteries. Further bioinformatics analysis, coimmunoprecipitation assays, and luciferase assays revealed that nidogen-2 specifically interacted with Jagged1, a conventional Notch ligand. Nidogen-2 maintained the VSMC contractile phenotype via Jagged1-Notch3 signaling but not Notch1 or Notch2 signaling. Nidogen-2 enhanced Jagged1 and Notch3 interaction and subsequent Notch3 activation. Reciprocally, Jagged1 and Notch3 interaction, signaling activation, and Jagged1-triggered VSMC differentiation were significantly repressed in nidogen-2–deficient VSMCs. In accordance, the suppressive effect of Jagged1 overexpression on neointima formation was attenuated in nidogen-2
–/–
mice compared with wild-type mice.

Conclusions:

Nidogen-2 maintains the contractile phenotype of VSMCs through Jagged1-Notch3 signaling in vitro and in vivo. Nidogen-2 is required for Jagged1-Notch3 signaling.
Determinants of Influenza Vaccine Uptake in Patients With Cardiovascular Disease and Strategies for Improvement
Authors: Bhugra Priyanka , Grandhi Gowtham R. , Mszar Reed , Satish Priyanka , Singh Rahul , Blaha Michael , Blankstein Ron , Virani Salim S. , Cainzos‐Achirica Miguel , Nasir Khurram
Published: July 2021

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Influenza infection is associated with an increased risk of cardiovascular events (myocardial infarction, stroke, and heart failure exacerbation) and mortality, and all‐cause mortality in patients with CVD. Infection with influenza leads to a systemic inflammatory and thrombogenic response in the host body, which further causes destabilization of atherosclerotic plaques. Influenza vaccination has been shown to be protective against cardiovascular and cerebrovascular events in several observational and prospective studies of at‐risk populations. Hence, many international guidelines recommend influenza vaccination for adults of all ages, especially for individuals with high‐risk conditions such as CVD. Despite these long‐standing recommendations, influenza vaccine uptake among US adults with CVD remains suboptimal. Specifically, vaccination uptake is strikingly low among patients aged <65 years, non‐Hispanic Black individuals, those without health insurance, and those with diminished access to healthcare services. Behavioral factors such as perceived vaccine efficacy, vaccine safety, and attitudes towards vaccination play an important role in vaccine acceptance at the individual and community levels. With the ongoing COVID‐19 pandemic, there is a potential threat of a concurrent epidemic with influenza. This would be devastating for vulnerable populations such as adults with CVD, further stressing the need for ensuring adequate influenza vaccination coverage. In this review, we describe a variety of strategies to improve the uptake of influenza vaccination in patients with CVD through improved understanding of key sociodemographic determinants and behaviors that are associated with vaccination, or the lack thereof. We further discuss the potential use of relevant strategies for COVID‐19 vaccine uptake among those with CVD.
Reforming Teacher Pension Plans: The Case of Kansas, the First
Teacher Cash Balance Plan
Authors: Costrell Robert M.
Published: July 2021

The ongoing crisis in teacher pension funding has led states to consider various reforms in plan design to replace the traditional benefit formulas, based on years of service and final average salary (FAS). One such design is a cash balance (CB) plan, long deployed in the private sector, and increasingly considered, but rarely yet adopted, for teachers. Such plans are structured with individual 401(k)-type retirement accounts, but with guaranteed returns. In this paper I examine how the nation's first CB plan for teachers, in Kansas, has played out for system costs, and the level and distribution of individual benefits, compared with the FAS plan it replaced. My key findings are: (1) employer-funded benefits were modestly reduced, despite the surface appearance of more generous employer contribution matches; (2) more importantly, the cost of the pension guarantee, which is off-the-books under standard actuarial accounting, was reduced quite substantially. In addition, benefits are more equitably distributed between short-term teachers and career teachers than under the back-loaded structure of benefits characteristic of FAS plans. The key to the plan's cost reduction is that the guaranteed return approximates a low-risk market return, considerably lower than the assumed return on risky assets.
Nature, the Nonhuman, and the Critique of Representation in Dieter Roth's Biodegradable Work
Authors: Árnadóttir Heiđa Björk
Published: July 2021

The practice of the Swiss-German artist Dieter Roth is distinguished by his pioneering use, since the early 1960s, of biodegradable materials. This essay examines the development of Roth's practice from Concrete Art to process-oriented and biodegradable work in the context of the reconceptualization of the “concrete” within the global artistic network of Fluxus in the postwar period. Highlighting the challenge Roth's biodegradable work poses to the traditional conceptual limits of the spheres of culture and nature, it argues that the profound transformation of Roth's practice in the early 1960s was rooted in the artist's growing discontent with the idealist and ethical premises of modern art and aesthetics, at the heart of which is the distinction between the human and the nonhuman. In this, Roth's biodegradable works precede later preoccupations with how humans relate to the natural environment, both in early earthworks from the late '60s and in contemporary practice. By examining Roth's biodegradable works in the context of Fluxus, this essay points towards aspects of Fluxus work that remain unexamined, most crucially the role of the natural and the nonhuman in Fluxus critiques of representation.
Art Writing and Allegory in the Anthropocene
Authors: Linden Liz , Ballard Susan
Published: July 2021

This essay traces the emergence of a rich and densely layered field of art writing within the Anthropocene. We ask: If the Anthropocene is all around us, where is it in art writing? We identify the emergence of Anthropocenic art writing: writing that is not art writing about the Anthropocene per se but rather art writing that takes its cue from the operations and outcomes of the Anthropocene itself, including its flagrant disregard for boundaries (disciplinary and otherwise), and its agency. We find such strategies already at work, particularly, in writing by artists such as Hito Steyerl, Martha Rosler, and Chris Kraus, as well as in writing that is polyphonic either through the collaboration of multiple writers or through collage. We map art writing's strata (its past and present delineations, some of its cardinal points) in order to identify sites of resistance to the accelerations of the contemporary era, which is to say places where deceleration and deliberation may be possible. Anthropocenic art writing claims such modes as its own. While for scientists the Anthropocene has been marked by the contestation of golden spikes, in art writing these proxy signals go far beyond employing “nature” and the environment as a theme or topic, taking the Anthropocene as an allegorical mode itself.
NFTs, or The Readymade Reversed
Authors: Joselit David
Published: July 2021

Modern and contemporary art have redefined the relationship between information and matter. Whether in the readymade's scrambling of the categories of art and commodity or Conceptual art's translation of matter into information, the artwork is embedded in a dynamic multi-media discourse. The NFT, or non-fungible-token, reverses this long genealogy of contemporary art by hijacking the category of art as nothing more than a tool for designing a new asset class, ripe for exuberant speculation. In short, the readymade—whose purpose was to demonstrate the fungibility of artworks when shifted from one discursive category to another—has been reversed.
Legal Guarantees of Public Participation in Spatial Planning and Development
Authors: Koniuszewska Ewa
Published: July 2021

Residents of self-governing communities, organized in formalized structures, often express the need to articulate their own interests and views or to have influence over the content of adopted legal solutions. They are ready to get involved in public matters and collaborate with local government units in regulating affairs that are important to a given local or regional community. Without a doubt, the issue of spatial planning and development falls under this category. The legislator obliged competent bodies to safeguard public participation in works on the study of conditions and directions of spatial development of a municipality, a local spatial development plan and a voivodship spatial development plan. The aim of this paper is to analyse the applicable legal solutions as guarantees of public participation in the planning procedure. Moreover, it provides a basis for assessing real possibilities of participation of residents of local government units in the process of passing planning acts and of real influence over their content.
Morphological variation in Bessera (Asparagaceae: Brodiaeoideae) allows for the recognition of two new species
Authors: GÁNDARA ETELVINA , ORTIZ-BRUNEL JUAN PABLO , CASTRO-CASTRO ARTURO , RUIZ-SANCHEZ EDUARDO
Published: July 2021

Bessera (Asparagaceae: Brodiaeoideae) is a genus endemic to Mexico. It currently has two described species: B. elegans with a wide geographic distribution from Durango and Sinaloa in the Sierra Madre Occidental, across the Transmexican Volcanic Belt to Oaxaca in the Sierra Madre del Sur, and B. tuitensis which is endemic to the Sierra del Cuale in Jalisco. Most of the morphological variation in Bessera occurs in western Mexico. We measured ten morphological characters for 280 plants from 21 populations, including B. tuitensis, to answer the following questions: Can Moore’s Group B of B. elegans be recognized as a different species? Are the newly included B. elegans s. l. populations from Colima different from B. elegans s. str., and from B. elegans s. l. (Moore’s group B)? Is there a significant relationship between morphological variation and climate variables for these species? The statistical analyses (ANOVA, MANOVA, and discriminant analysis) allowed us to recognize two new Bessera species, described here as B. elegantissima and B. ramirezii. Additionally, we provide a morphological key for Bessera, illustrations, a distribution map, and photographs of all the species.
Updated checklist of the Cerambycidae (Coleoptera: Chrysomeloidea) from Mexico
Authors: PÉREZ-FLORES OSCAR , TOLEDO-HERNÁNDEZ VÍCTOR H. , BEZARK LARRY G. , MONNÉ MIGUEL A.
Published: July 2021

The knowledge of the family Cerambycidae (Coleoptera) from Mexico is updated based on the literature where records of species from Mexico have been published. In addition, Callimoxys sanguinicollis (Olivier, 1800), Laticranium mandibulare Lane 1959, Bellamira scalaris (Say, 1826), and Strangalia opleri Linsley & Chemsak, 1976 are recorded as new records for the country. A total of 1,836 species (including subspecies), 503 genera, 81 tribes, and seven subfamilies are recorded from Mexico. A complete checklist of taxa is provided.
Dorothee, a new genus of Cryptinae (Hymenoptera: Ichneumonidae) from Peru
Authors: HERRERA-FLÓREZ ANDRÉS FABIÁN
Published: July 2021

In this contribution, a new genus (and species) of Ceratocryptina (Hymenoptera: Ichneumonidae, Cryptinae, Cryptini): Dorothee panguanensis n. sp. is described from Peru. A diagnosis and an identification key to that subtribe of Cryptini are provided.
The rare genus Therophilus Wesmael (Braconidae: Agathidinae) in Brazil with description of two new species
Authors: IZA-CAMPOS GIULIA , PENTEADO-DIAS ANGÉLICA
Published: July 2021

Two new species of Therophilus Wesmael (Braconidae: Agathidinae) from Brazil are described: T. shimborii sp. n. and T. onodyi sp. n. Maps with the collection sites of both species are presented.