bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterizing Spatiotemporal Complex Patterns from Entropy Measures
Authors: Barauna Luan Orion , Sautter Rubens Andreas , Rosa Reinaldo Roberto , Rempel Erico , Frery Alejandro C.
Published: February 2024

In addition to their importance in statistical thermodynamics, probabilistic entropy measurements are crucial for understanding and analyzing complex systems, with diverse applications in time series and one-dimensional profiles. However, extending these methods to two- and three-dimensional data still requires further development. In this study, we present a new method to classify spatiotemporal processes based on entropy measurements. To test and validate the method, we selected four classes of similar processes related to the evolution of random patterns: dynamic colored noises ((i)~white and (ii)~red); (iii)~weak turbulence from reaction-diffusion; (iv)~hydrodynamic fully developed turbulence, and (v)~plasma turbulence from MHD. Considering seven possible ways to measure entropy from a matrix, we present the method as a parameter space composed of the two best separating measures of the five selected classes. The results highlight better combined performance of Shannon Permutation Entropy ($S^p_H$) and a new approach based on Tsallis Spectral Permutation Entropy ($S^s_q$). Notably, our observations reveal the segregation of reaction terms in this $S^p_H \times S^s_q$ space, a result that identifies specific sectors for each class of dynamic process, and can be used to train machine learning models for automatic classification of complex spatiotemporal patterns.
The Impacts of Climatic Features on Residents and Residences: A UK Study
Authors: ONUS EHIS LAWRENCE , Chinyio Ezekiel , Daniel Emmanuel Itodo
Published: February 2024

Introductions- Liveable housing environments face the menace of global climate change. In-frastructure (including buildings and houses) continuously experiences significant impacts ex-acerbated by natural variability in climate. The study addressed how climate change impacts the resilience of residential buildings, increased maintenance frequency, and the wellbeing and comfort of residents in UK residential buildings.
Design/Methodology/Approach: This study used deductive reasoning and an empirical epis-temological methodology as a data-collecting basis to evaluate primary information obtained via a questionnaire. Regression analysis was ultimately employed to analyse the collected da-ta.
Result/Discussions: The findings show a significant relationship between climate change and the wellbeing of the occupants of UK residential buildings. Also, the results show that social wellbeing is more important to the occupants than mental and physical wellbeing. It reveals that residential buildings in the UK suffer the cost of maintenance due to continuous reduc-tion in the building fabric's resilience to the impacts of climate change; for instance, a recent increase in rainfall/storms results in unprecedented flooding, which continues to damage the UK residential building fabrics.
Experimental and Numerical Study on Flexural Behavior of Concrete Beam With Notch and Repairing Materials
Authors: Khan Waseem , Akhtar Saleem , Rawat Aruna , Basu Anindya
Published: February 2024

In a concrete beam initially crack is generated at the tension side under the effect of flexure, shear and torsional loadings. Accordingly, these weak concrete members require repair and/or strengthening to increase or restore their internal load capacity. In the current experimental and numerical investigations on concrete beam having different width to depth ratio of notch on its ultimate flexural load under one-point loading was considered. Further, the flexural behavior performance of notch concrete beam repaired with the three repair materials cement mortar, bacterial mortar and adhesive was also examined. Consequently, a comparative study is imple-mented between the experimental and numerical results. Concrete Damage plasticity (CDP) model was used for finite element numerical analysis of beam. The differences in numerical and experimental measured results ranges from 0.65 - 22.20 % for the ultimate load carrying capacity. As the notch size increases the ultimate load carrying capacity of beam was reduced. Addition-ally, linear regression model is used to predict the ultimate load values at an interval of 5 mm notch width up to maximum width of notch 100 mm. It can be observed that the ultimate load capacity for repaired beam is increased as compared to the notch beam for all the three repairing materials under consideration. The maximum ultimate load was increased in case of notch beam repaired using adhesive. As compared to the cement mortar the performance of the bacterial mortar in terms of the ultimate load was more. The bacterial mortar is found more sustainable and more durable as a repair material for the concrete structures.
Effectiveness and possibilities of amniotic membrane application in repeat cesarean section
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ishchenko A.I. , Aleksandrov L.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Trifonova N.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Nikonov A.P. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Fedorova E.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ageev M.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Obosyan L.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Kosova D.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

This article presents a new method of uterine closure in repeat cesarean section using absorbable suture anchors and additional sealing of the scar with amniotic membrane. The proposed method is not followed by excessive blood loss, does not prolong the duration of surgical intervention and postoperative hospitalization. This method also reduces the incidence of intra- and postoperative complications and cesarean scar defect, eliminates the need for additional hemostatic suturing of the uterus, and promotes myometrial regeneration. Key words: amnion, amniotic membrane, cesarean section, cesarean scar defect
Association of HLA-G (rs1063320) gene polymorphism with recurrent pregnancy loss
Authors:   University of Basrah, Basrah, Iraq, Al-Ammar N.S. , Aldhahi M.A. ,   University of Basrah, Basrah, Iraq, Al-Badran I.M. ,   Al-Zahraa College of Medicine, Basrah, Iraq, Faraj A.H. ,   Public Health Laboratory, Sulaymaniyah, Iraq
Published: February 2024

Recurrent abortion, or miscarriage, is defined as pregnancy loss before 20 weeks’ gestation and is different from infertility. Commonly two or more pregnancies are lost spontaneously. The human leukocyte antigen (HLA) has been linked to many diseases. The HLA-G gene polymorphism may have an impact on pregnancy outcome. Objective. To study the association between the HLA-G (rs1063320) gene polymorphism and recurrent pregnancy loss (RPL). Patients and methods. This study included 100 women with RPL aged 20 to 45 years (a study group) and 50 age-matched healthy women with at least two successful pregnancies and normal blood pressure (a control group). Women with normal blood pressure, endocrine disorders, infections, and anatomical defects were excluded from the study group. All samples and data related to the studied cases were obtained from private clinics of genealogists between 2019 and 2022. Peripheral blood samples were obtained from patients and healthy controls. DNA extraction was done using the Promega Extraction Kit. PCR was then performed using the Amplification Refractory Mutation System (ARMS) to amplify the gene region specific for the HLA-G (rs1063320) single nucleotide polymorphism (SNP). Results. The frequency of CG, GG, and CC alleles was higher in women with RPL than in healthy controls. The frequency of CG allele in the study group was 18% compared to 8% in the control group, which was statistically significant (p < 0.05). Conclusion. A high association was found between the HLA-G (rs1063320) gene polymorphism and RPL. Key words: HLA-G, polymorphism, recurrent pregnancy loss, SNP, ARMS-PCR
Application of amniotic membranes in clinical medicine
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Kosova D.A. , Aleksandrov L.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ishchenko A.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Trifonova N.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Nikonov A.P. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lavrentyeva K.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ageev M.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Fedorova E.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Zholobova M.N. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Berishvili M.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Proklova G.F. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Zemlina N.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Naumenko N.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lyundup A.V. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation
Published: February 2024

The amniotic membrane (AM), or amnion, is the innermost layer of the placenta; it surrounds the embryo and delimits the amniotic cavity, which is filled with amniotic fluid. The use of AM in various medical areas has been increasing in recent years due to its extracellular matrix structure, presence of stem cells, and biological properties that improve both wound healing and tissue regeneration. The amnion also possesses antimicrobial, anti-inflammatory, antifibrotic, and antiangiogenic properties. It does not cause immune reactions, and its use does not raise ethical concerns. This review describes the application of the membrane in ophthalmology, dermatology, gynecology, and other fields. The membrane can be used as either a whole tissue or a matrix for stem cell culturing in vitro. The review also discusses the results of using amnion epithelial and mesenchymal stem cells in the therapy for Parkinson’s disease, diabetes, and fibrosis due to myocardial infarction. Conclusion. AM has many properties that prevent scar formation, reduce inflammation, and promote wound healing. Due to these properties, AM is used in many fields of medicine, and further studies on its structure, functions and properties will undoubtedly reveal new areas of clinical application. Key words: amnion, amniotic membrane, human amniotic mesenchymal stem cells, human amniotic epithelial stem cells, amniotic membrane transplantation
Psychosomatic disorders associated with functional diseases of the female reproductive system at different ages
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Petelin D.S. , Kondrateva K.K. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Dzhibladze T.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Volel B.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   Mental Health Research Center, Moscow, Russian Federation
Published: February 2024

Psychosomatic disorders, along with other medical, somatic, and socio-economic issues, play an important role in fertility decline worldwide. Research has conclusively shown that there is a two-way relationship between a women’s reproductive function and mental health, necessitating the development of interdisciplinary teams that include gynecologists, reproductive and mental health specialists. Objective. To identify the main forms of psychosomatic disorders related to changes in the female reproductive system. It was shown that psychosomatic disorders can manifest in close connection with the menstrual cycle (stress-induced menstrual disorders, premenstrual dysphoric disorder), during pregnancy and postpartum (perinatal mood disorders, primarily depression), and during the menopausal period (involutional hysteria and involutional melancholia). Data are presented on the prevalence of the disorders discussed, their pathogenesis, clinical presentation, and approaches to diagnosis. Key words: psychosomatics, reproductive health, hypothalamic amenorrhea, premenstrual dysphoric disorder, perinatal depression, climacteric syndrome.
Organoleptic Quality of Egg Chips at Various Types and Levels of Fillers
Authors: Hikmah Hikmah , Kartina Kartina , Nahariah Nahariah
Published: February 2024

Egg chips are not yet common in society; therefore it is necessary to require attention for consumer assessments. Consumer ratings of egg chips indicate that consumers can accept egg chip products. The study aims to determine the effect of adding the types and levels of filler on the organoleptic quality of egg chips. Eighty-one eggs were used in the research. The studies were arranged based on a completely randomized design with a 3 x 3 factorial pattern with 3 replications. The first factor consisted of 3 types of fillers; there are tapioca powder, soybean protein isolate, and porang powder. The second factor was the level of filler (%) 3, 6, and 9 respectively. The parameters measured were egg chips' organoleptic quality (aroma, color, texture, and fondness). The results data indicated that the types and levels of fillers had a highly significant effect (P<0.01) on aroma egg chips. There was an interaction between types and levels of filler on the aroma. There was no significant difference (P>0.05) in color, texture, and fondness for egg chips. Adding the type and level of filler material could improve the organoleptic quality of egg chips. The addition of 9% of tapioca powder can increase the aroma of egg chips.
Keywords: Egg powder, egg chips, organoleptic
Consumption and Digestibility Studies in Goats Fed with Complete Feed Corn Tumpi and Red Dragon Fruit Peel Flour (Hylocereus Sp.)
Authors: Mariam Mariam , Natsir Asmuddin , Syahrir Syahriani
Published: February 2024

Utilization of unconventional materials such as corn tumpi and dragon fruit peel flour as an alternative feed ingredient for ruminants, especially goats. This study aims to examine the effect of providing complete feed containing corn tumpi with dragon fruit peel flour at different levels on consumption and digestibility of goats. This study used 12 local male goats with ages ranging from 1 to 1.5 years which were randomly assigned to metabolic cages. The study used a Randomized Block Design (RBD) method with 3 treatments and 4 groups. The treatments consisted of P1: Complete feed containing 50% corn tumpi, P2: Complete feed containing 45% corn tumpi and 5% dragon fruit peel flour and P3: Complete feed containing 40% corn tumpi and 10% dragon fruit peel flour. The results showed that the treatment of complete feed containing corn tumpi with dragon fruit peel flour at different levels had a significant effect (P<0.05) on dry matter consumption and organic matter consumption. Dry matter consumption ranged from 296.88 – 461.64 g/h/day, and nitrogen consumption was between 265.74 – 407.72 g/h/day. Treatment of complete feed containing corn tumpi with dragon fruit peel flour at different levels had no significant effect (P>0.05) on dry matter digestibility and organic matter digestibility. Dry matter digestibility ranged from 82.75 – 87.50 %, and organic matter digestibility between 84.5 – 88.75 %. It was concluded that based on estimates of dry matter consumption and organic matter consumption, the use of alternative ingredients for corn tumpi with dragon fruit peel flour up to a level of 10% could be used as a complete mix of feed ingredients for ruminants, especially goats.
Reproductive Performance of Bali Cows through Artificial Insemination Program in Polewali Mandar Regency, West Sulawesi Province
Authors: Muslimiah Muslimiah , Priyanto Rudy , Jakaria Jakaria
Published: February 2024

Intensification of artificial insemination (AI) in Bali cattle is a government program to increase the population and productivity of local cattle. The objective of this study was to examine the reproductive performance of Bali cows through the AI program in Polewali Mandar Regency, West Sulawesi. The study was conducted in two different locations, i.e. in the low lands (<300mASL) including Wonomulyo and Campalagian Districs, and high lands (>300mASL) including Limboro and Bulo Districts. Data collection was carried out on farmers and inseminators profiles, and cow’s reproductive parameters including service per conception (S/C), conception rate (CR), calving rate (CvR), calving interval (CI) and Calf Mortality (CM). These data were calculated and analyzed descriptively. The cows in this study were raised by farmers in small-scale farm, mostly under 5 heads. The cattle breeding through AI program was carried out by inseminators with over 10 years of experience. In the lowlands, S/C values were 1.26-1.17 and CI were 360 to 366.31 days, respectively. Bali cows that were inseminated using Bali bull semen had a CvR of 75.69% which were higher than those using Simmental bull semen (CvR 49.69%;). While in the highlands, Bali cows that were inseminated with Bali bull semen tended to have higher S/C (1.30) and CI (356.95 days) values but had CvR of 61.00% and CR 77.00% which was also higher than that of Simmental bull semen (S/C 1,50; CI 412,86 days; CvR 50.00%; CR 66.67%). The high S/C in the highlands (1.50) is due to location constraints or the distance between the livestock and the inseminator's residence which is quite far, so it takes time to carry out AI services and is one of the factors that can cause the provision of AI services for female cows in heat is not optimal. In the highlands, most of the cattle are grazed in the grazing areas, making it difficult for breeders to detect estrus. In general, Bali cattle produced by AI in the low lands of Polewali Mandar district tended to have better reproductive performance than those in the high lands. The S/C in the low lands (1.26 and 1.17) is lower than that in the high lands (1.3 and 1.5).
Keywords: AI, Bali cows, lower land, high land reproductive performance
Strategies for primary health care models.
Authors:   Federal State Budgetary Educational Institution of Higher Education «Samara State Medical University» of the Ministry of Healthcare of the Russian Federation, Arkhipova S. V. , Dvoinikov S. I. ,   Federal State Budgetary Educational Institution of Higher Education «Samara State Medical University» of the Ministry of Healthcare of the Russian Federation
Published: February 2024

At present, primary health care is improved by the new models of organisation’s work. All elements of the transformational change process are based on a patient-centered system of medical care that is sustainable in the long term. The urgent problem for outpatient clinics to become improve effectively using a patient-centered approach. The aim of this study was to describe the strategies on patient-centred outcomes used in primary care in Russian regions. Materials and methods. A systematic literature review was conducted in Google Scholar and Elibrary databases using keywords. According to the inclusion criteria, the studies described the experience of implementing new strategies in the Russian primary health care system between 2017 and 2023, resulted in a total of 2874 articles being found. After reviewing the abstracts of the retrieved articles, 211 were retained for further analysis. Another 175 articles were excluded after reading the full text. Results. In this article, we describe a set of priorities strategies related with a new models in primary health care: expanded role of nurses in primary health care, improvement of Ambulatory complementary technologies, use of new organizational structures of medical care, using remote technologies. Findings. The strategies of new organizational models in primary health care are based on the successful experience of reforms. Factors affecting the expansion of strategies to other health care organizations include: teamwork of medical and non-medical professionals, low level of interprofessional collaboration to ensure effective implementation and delivery of patient-centered care, lack of incentives to improve the Ambulatory complementary technologies, patient routing problem for primary health care services, systematization of experience of telemedicine technologies in outpatient practice.
Experience of providing medical care for patients with stroke in teleconsulted stroke units in the Sverdlovsk region.
Authors:   GAUZ SO «Sverdlovsk Regional Clinical Hospital», Alasheev А. М. , Prazdnichkova Е.V. ,   GAUZ SO «Sverdlovsk Regional Clinical Hospital», Belkin А. А. ,   GAUZ SO «Sverdlovsk Regional Clinical Hospital»
Published: February 2024

Introduction. One of the problems of providing specialized care for ischemic stroke is to achieve high rates of intravenous thrombolytic therapy (IVT) in areas characterized by low population density and large distance from the nearest stroke unit (delivery time more than 1 h). In Sverdlovsk region, in order to solve this problem in such territories, three teleconsulted stroke units equipped with CT scanners and having resuscitation beds were organized in 2021. Objective. To study the dynamics of the rates of intravenous thrombolytic therapy for ischemic stroke in the territories with a teleconsulted stroke units (in addition to the stroke unit). Materials and Methods. We retrospectively analyzed the data of 85 patients treated in three teleconsulted stroke units (teleSU) of the Sverdlovsk region in 2022 and compared the dynamics of the increase in the IVT rate (R parameter,%/year) in these territories in comparison with the rest of the municipalities of the Sverdlovsk region. Results. According to the results of the study, it was found that the rate of IVT in teleSU was 9,0%, which is generally higher than the average value in the Sverdlovsk Region (5,1%) in the analyzed period. The analysis of the statistical data from 2020 to 2022 revealed that establishment of additional teleconsulted stroke units in the territories with low population density in 2022 has led to the increase of the number of procedures of IVT for ischemic stroke. Dynamics of growth of this indicator, became equale of that in the rest of the municipalities of the region. Conclusions. The organization of teleSU in addition to the main SU in the territories with low population density allows to increase the availability of specialized medical care and to increase the IVT rate in patients with ischemic stroke.
Diversidad y composición de anfibios en el valle del río Cimitarra, sur de la serranía de San Lucas, Colombia
Authors: Rojas-Morales Julián A. , González Carvajal Juliett M.
Published: February 2024

La serranía de San Lucas (Colombia) se considera de alto valor para la conservación de la biodiversidad, pero poco se sabe sobre su fauna. Entre finales de 2016 (lluvias) e inicios de 2017 (seca) se realizaron dos salidas de campo para caracterizar la fauna de anfibios y estimar su diversidad taxonómica en el río Cimitarra, al sur de esta serranía. Como resultado, se registraron 183 individuos pertenecientes a 23 especies, 15 géneros y 8 familias. Aunque la riqueza no difirió entre temporadas, la diversidad fue casi el doble en temporada seca que en la de lluvia, siendo el bosque natural fragmentado la cobertura más diversa con 14,2 especies (q1). La composición de anfibios fue diferente entre temporadas y coberturas, con altos valores de diversidad β debido principalmente al anidamiento en el ensamblaje. Los anfibios del río Cimitarra muestran un patrón de similitud con otras localidades dependiendo de su distancia geográfica. Estos resultados contribuyen con información para ser comparada con la diversidad de anfibios en áreas más intervenidas del Magdalena Medio y el bosque húmedo en general. Sin embargo, se debe analizar la dinámica espaciotemporal de los anfibios en una escala de tiempo mayor y evaluar las variaciones interanuales.
Plan de exportación de conserva de tilapia en salsa de cocona hacia el mercado de Barcelona - España, 2023
Authors:   , Espíritu Quincho Josselyn Jakie , Gozar Guerra Cristhofer Renzo , Lopez Yaringaño Mary Luz
Published: February 2024

El principal objetivo del presente plan de exportación fue la comercialización de la conserva de tilapia en salsa de cocona al mercado español debido a la carencia de innovación de insumos dentro de productos finales del sector pesquero y/o acuícola, para ello se analizó la demanda de la ciudad de Barcelona mediante un cuestionario estructurado por 10 ítems bajo la escala de Likert en una muestra significativa de 45 ciudadanos. En esa misma línea, se analizó también el sector para identificar a los principales competidores y evidenciar la viabilidad en el estudio de prefactibilidad de la constitución empresarial de Sweet Ocean S.A.C. contemplando las tendencias de consumo de los usuarios pertenecientes al target establecido. Por ende, el estudio estratégico empleó 6 capítulos, en donde se consideró efectuar un análisis externo e interno a fin de establecer objetivos smart con el propósito de establecer los planes de acción en el ámbito de marketing internacional, logística internacional, comercio internacional y viabilidad económica - financiera; para que posteriormente tras indicadores estos puedan ser medidos así como evaluados dentro de las variaciones del plan. Por último, se concretaron las conclusiones tras el análisis y las recomendaciones.
Capacidad discriminativa de los componentes de la ecografía diafragmática para predecir extubación exitosa en pacientes críticos de un Hospital público peruano
Authors:   , Martinez Davalos Alexandra Katherine
Published: February 2024

La ventilación mecánica, específicamente el momento de la extubación, sigue siendo motivo de preocupación pues tanto una extubación precoz como tardía conllevan riesgos y complicaciones. Es precisa la necesidad de herramientas que orienten la decisión de los médicos de extubar considerando ciertos criterios. Uno de estos es el uso de medidas directas de la función diafragmática, donde la ecografía cumple un papel esencial al demostrar ser de utilidad por su precisión y factibilidad. Objetivos: El objetivo de este trabajo será determinar la capacidad discriminativa de los componentes de la ecografía diafragmática para predecir la extubación exitosa en pacientes atendidos en la unidad de cuidados intensivos del Hospital Nacional Arzobispo Loayza durante el 2022. Metodología: Se trata de un estudio observacional, analítico de caso-control, basado en el análisis secundario de una base de datos. La población estará conformada por pacientes críticos mayores de 18 años con ventilación mecánica prolongada (21 días a más), ingresados en la unidad de cuidados intensivos del Hospital Nacional Arzobispo Loayza, durante el periodo enero a diciembre del 2022. Toda la información será extraída de las historias clínicas. Para evaluar la utilidad de la ecografía diafragmática como predictor del éxito en la extubación, se calculará la sensibilidad, especificidad, el valor predictivo positivo y valor predictivo negativo.
Estimación de la concentración de PM10 y PM2,5 en las estaciones del SENAMHI ubicadas en Lima metropolitana del año 2018
Authors:   , Delgadillo Arredondo Angela Sibel
Published: February 2024

Lima Metropolitana cuenta con 10 estaciones de monitoreo de calidad de aire del Servicio Nacional de Meteorología e Hidrología (SENAMHI) para determinar concentraciones de material particulado (PM) y otros gases. Sin embargo, los equipos de medición no logran registrar todos los datos por diversos motivos, dejando vacíos de información en el registro. Ante ello, el objetivo del estudio fue estimar los valores de concentración de PM10 a partir de valores de PM2,5 y/o viceversa, en las estaciones de monitoreo del SENAMHI en Lima metropolitana, para completar los vacíos de información de concentraciones de PM. Los datos obtenidos fueron de la base de datos del SENAMHI 2018, siendo estas estaciones: Puente piedra (PPD), Carabayllo (CRB), San Martín de Porres (SMP), San Juan de Lurigancho (SJL), Huachipa (HCH), Villa María del Triunfo (VMT), Santa Anita (STA), San Borja (SBJ), Ate (ATE) y Jesús María (CDM). Estos datos fueron analizados mediante el método de regresión lineal simple para correlacionar los datos de concentración de PM10 con PM2,5 para cada estación de monitoreo. Una vez obtenido el modelo para cada estación, se procedió a completar los datos no registrado de PM10 y PM 2,5. Los resultados mostraron un modelo para cada estación y para cada PM (PM10 y PM2,5), siendo la estación con mayor coeficiente de determinación (R2), la estación CDM con 0.781, seguidos de la estación STA y ATE con valores de 0.630 y 0.526, respectivamente; y también se observó que algunas estaciones presentaron un R2 bajo. En conclusión, se generaron ecuaciones a partir de regresión lineal para las 10 estaciones en estudio, siendo la estación Jesús Maria (CDM), la estación que mejor relación tiene entre las variables PM10 y PM2,5, con un mayor valor de R2 que explica el modelo mencionado para completar datos no registrados de PM que...
Impacto del cultivo de cacao en los niveles de pobreza: Evidencia regional, 2008-2019
Authors:   , Tapia Tovar Gibel Andrea , Santos Pintado Sintia Yanela
Published: February 2024

El objetivo de esta investigación es analizar el impacto del cultivo del cacao en los niveles de pobreza de las regiones productoras. Para esto, se utiliza un panel de datos con información de 16 regiones productoras de cacao para el período 2008-2019. La metodología empírica se basa en la estimación de modelos de regresión para datos de panel usando los estimadores OLS para datos agrupados (pooled OLS), efectos fijos y aleatorios. La variable endógena es la variación en la tasa de pobreza y las variables explicativas son la tasa de crecimiento del precio del cacao y el crecimiento de la productividad del cacao (producción per cápita). Para mitigar el efecto por omisión de variables, se incluyen variables de control y se utilizan variables instrumentales a través del estimador 2SLS (OLS en dos etapas). Los resultados muestran que el crecimiento de la productividad del cacao contribuye a reducir la variación de la pobreza, mas no así el crecimiento en el precio del cacao. Específicamente, un aumento de 20 puntos porcentuales (pp) en la tasa de crecimiento de la productividad implica que la variación de la pobreza se reduce en 0.2 pp.
Nivel de conocimiento que tienen los nutricionistas de atención primaria en Lima Metropolitana sobre el método “Baby Led Weaning” en niños de 6 a 24 meses de edad
Authors:   , Espinoza Chacon Daniela Briyith
Published: February 2024

Introducción: El método Baby Led Weaning es como alternativa al método tradicional en la alimentación complementaria, que utiliza la capacidad del lactante para alimentarse por sí mismo con alimentos sólidos en lugar de ser alimentado con pures mediante una cuchara, esto facilita la adaptación del bebé a nuevos sabores y consistencias, favoreciendo la masticación frente a la succión y promueve el desarrollo de la motricidad fina y el desarrollo madurativo del bebé. Objetivo: Determinar el nivel de conocimiento que tienen los nutricionistas de atención primaria en Lima Metropolitana sobre el método de alimentación complementaria Baby Led Weaning en niños de 6 a 24 meses de edad y los factores asociados. Métodos: Esta investigación se diseñó como un estudio transversal analítico en una muestra final de 151 nutricionistas. Se utilizo un cuestionario generado y difundido a través de formularios de Google entre los meses de julio a noviembre de 2022. Los resultados se analizaron mediante el test de Chi-Cuadrado y cálculos de RP mediante el modelo de regresión de Poisson . Resultados: El 22,52% de los nutricionistas habían escuchado alguna vez el método Baby Led Weaning, del cual un grupo minoritario del 17,65% tiene conocimiento suficiente sobre el método, según el análisis de regresión logística bivariado se observa que los nutricionistas del sexo masculino tienen 6% más probabilidades significativas de recomendar una alimentación complementaria tradicional en comparación al sexo femenino. Conclusión: Los nutricionistas que conforman la muestra obtenida, carecen de conocimientos suficientes sobre el método BLW. Asimismo, se identificó asociación significativa entre el método de alimentación complementaria recomendado y el nivel de conocimiento sobre BLW.
Estudio bibliométrico sobre Síndrome de Intestino Corto en pacientes pedátricos 2010 - 2022
Authors:   , Morveli Farroñan Angela Ariane , Iglesias Parra Nicolas Danilo
Published: February 2024

Objetivo del estudio: Establecer características bibliométricas de producción científica sobre síndrome de intestino corto en pacientes pediátricos, desde el período 2010 - 2022. Metodología: Se realizó un análisis bibliométrico en la base de datos Scopus. Se incluyeron los documentos publicados entre el 2010 y 2022. Culminada la recolección de los artículos, se excluyeron los duplicados y posteriormente se hizo una revisión de aquellos que cumplan con los criterios de inclusión y exclusión. Después de este proceso de verificación, se exportaron dichos artículos seleccionados a una base de datos usando el programa Excel 2019 y se usó el programa VOSviewer versión 1.6.18 para poder realizar y visualizar redes bibliométricas. Se realizó un análisis descriptivo con las variables categóricas y cuantitativas. Resultados: Se recuperó un total de 520 documentos, incluidos 160 autores, 108 instituciones, 45 países/regiones. Estados Unidos fue el país contribuyente más destacado, siendo Pakarinen MP el autor más con mayor número de publicaciones. La institución más prolífica fue Boston Children Hospital y el Journal of Pediatric Gastroenterology and Nutrition es la revista principal en este campo. Las palabras clave de mayor frecuencia fueron Síndrome de Intestino Corto, Insuficiencia Intestinal, Niños y Nutrición Parenteral. El autor con más publicaciones es Mikko P. Pakarinen de nacionalidad finlandesa. La institución con mayor número de publicaciones fue Boston Children´s Hospital, así como las entidades que financiaron el mayor número de publicaciones estuvieron relacionadas con los institutos de salud (NIH) de Estados Unidos. Conclusiones: Según los datos recopilados, se observa un aumento en las publicaciones sobre síndrome de intestino corto en pacientes pediátricos en los últimos 12 años, siendo Estados Unidos el país líder en este tema, teniendo a sus…
Diagnosis and medical treatment of otitis externa in a ragdoll cat: A case report
Authors: Usrina Nora , Habibie Maulana , Darmawi Darmawi , Amiruddin Amiruddin , Zulkifli Baidillah , Yusriani Yenni
Published: February 2024

Otitis is a disease that is often found due to the cat's ears being unclean and causing earwax to build up along with fluid. Otitis is caused by inflammation of the epithelium of the ear canal and also surrounding structures such as the external auditory meatus and pinna. A 3-month-old Ragdoll cat, male, with white and black hair on the ears, was examined with complaints of head tilting and frequent head shaking, pus in the ears, and inflammation. Clinical examination revealed erythema. The ear wax swab examination results showed an Otodectes cynotis mite infection. The results of the bacterial culture examination showed the presence of Klebsiella sp bacterial infection. The animal was diagnosed with otitis externa. Treatment for otitis externa is given by Dexamethasone, Erlamycetin® (Chloramphenicol 1%), Ivermectin, and lidocaine. The accumulated earwax is also cleaned using a cotton bud and saline. Five days after therapy the cat showed recovery.
Twin Prime Conjecture Proof
Authors: Thompson Daniel
Published: February 2024

The Twin Prime conjecture first proposed by French mathematician Alphonse de Polignac in the year 1846 remains unproven until now. This paper sets out to prove the Twin Prime conjecture by creating a system of equations and finding both a y element of ℕ, (y ϵ ℕ) and a y element of k, (y ϵ k) to find the twin prime values and then two further values where each will differ by an exact amount. From this proof the method demonstrates that the elements of these phenomena prove that there will be an infinite number of twin primes that differ by two.
MSC: 11-xx
Shaping Long-term Care Insurance Intentions among Chinese Older Adults: Role of Information Interventions in Health Risks
Authors: Leng Anli , Liu Jin , Hao Jiaozhi , Maitland Elizabeth , Nicholas Stephen , Wang Jian
Published: February 2024

Long-term care insurance (LTCI) is an essential system in the context of fast-growing population aging, yet it lacks evidence on how to improve the acceptance and coverage of non-compulsory LTCI in China. Using a survey experiment, we randomly assigned 1025 older adults to control group, disability information group and dementia information group, and explored whether information about the adverse health outcomes would change their willingness to LTCI insure. We found that disability and dementia information significantly changed respondents’ willingness to LTCI insure, and health status had negative moderating effects on the relationship between information interventions and the change of LTCI intentions. Also, we found respondents with lower education and living in non-pilot cities were more sensitive to information interventions. We recommend LTCI information campaigns differentiating information by dementia-related and disability-related risks; by LTCI pilot and non-pilot cities; by education levels and by physical and mental health status.
Protective effect of increased O-GlcNAc cycling against 6-OHDA induced Parkinson's disease pathology
Authors: Han Inn-Oc , Kim Dong Yeol , Kim Sang-Min , Cho Eun-Jeong , Kwak Hyo-Bum
Published: February 2024

This study aimed to elucidate the role of O-GlcNAc cycling in 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD)-like neurodegeneration and the underlying mechanisms. We observed dose-dependent downregulation of O-GlcNAcylation, accompanied by an increase in O-GlcNAcase following 6-OHDA treatment in both mouse brain and Neuro2a cells. Intriguingly, elevation of O-GlcNAcylation through glucosamine (GlcN) injection provided protection against PD pathogenesis induced by 6-OHDA. At the behavioral level, GlcN ameliorated motor deficits induced by 6-OHDA, as determined using the pole, cylinder, and apomorphine rotation tests. Additionally, GlcN alleviated 6-OHDA-induced neuroinflammation and mitochondrial dysfunction. Remarkably, elevated O-GlcNAcylation, achieved through O-GlcNAc transferase (OGT) overexpression in mouse brain, provided protection against 6-OHDA-induced PD pathology encompassing neuronal cell death, motor deficits, neuroinflammation, and mitochondrial dysfunction. Our collective findings imply that O-GlcNAcylation plays a crucial role in the normal functioning of dopamine neurons. Furthermore, enhancement of O-GlcNAcylation through genetic and pharmacological manipulation could effectively alleviate neurodegeneration and motor impairment in an animal model of PD. These results offer a potential strategy for protecting against deterioration of dopamine neurons implicated in PD pathogenesis.
Comparison of the level of growth factors in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis
Authors: Karci Bilge , Savas Hasan Basri
Published: February 2024

Background
This study purposed to assess and compare the concentrations of growth factors, white blood cells (WBCs), and platelets in injectable platelet-rich fibrin (i-PRF) derived from persons with healthy periodontal conditions and those with chronic periodontitis.
Methods
Venous blood samples were obtained from patients diagnosed with chronic periodontitis (test group) and people with healthy periodontal conditions (control group). The I-PRF was acquired from blood that had been centrifuged. The growth factors released from i-PRFs were compared among groups using the ELISA test. Furthermore, the amounts of white blood cells (WBCs) and platelets were also compared.
Results
Comparison was made between the i-PRFs obtained from the test and control groups. No discernible disparity was detected. The test group had a markedly elevated white blood cell (WBC) count compared to the control group (P = 0.025). Nevertheless, the data obtained from the whole-blood analysis, including the platelet count, did not show any statistically significant differences between the groups (P = 0.387). Furthermore, there was no notable link observed between the white blood cells (WBCs) and growth factors in either of the groups (P > 0.05).
Conclusions
The levels of growth factors (VEGF, IGF-1, TGF-β1, PDGF-BB, EGF) in i-PRFs varied significantly among people. Nevertheless, there was no substantial disparity observed between the two groups. This suggests that the levels of growth factors may be unaffected by the periodontal disease state of the participants. These findings provide evidence for the practical application of i-PRFs as a method for delivering autologous growth factors.
Enhanced Recovery After Surgery (ERAS) versus standard recovery after radical cystectomy – a matched-pair analysis
Authors: Fischer Nikita Dhruva , Brandt Maximilian Peter , Epple Stefan , Horn Felix , Haack Maximilian , Duwe Gregor , Sparwasser Peter , Dotzauer Robert , Thomas Anita , Tsaur Igor , Haferkamp Axel , Jäger Wolfgang
Published: February 2024

Background
Radical cystectomy (RC) is marked by a tremendous potential for short and long-term complications. By introduction of Enhanced Recovery After Surgery (ERAS) protocols serious endeavors have been made in order to reduce postoperative morbidity in favor of a fast-track recovery. In this study, we investigated the impact of our in-house ERAS protocol on postoperative complications and hospital stay.
Methods
We identified 106 patients who received standard care of treatment post-surgery (non-ERAS group). After implementation of our ERAS protocol, we prospectively recorded data from 53 patients (ERAS group) up to 90 days post-surgery. Non-ERAS patients were matched with ERAS patients with respect to preoperative clinical characteristics. Statistical analysis was conducted by matched-pair analysis and Wilcoxon-Mann-Whitney-Test.
Results
Altogether 51 patients were matched. Considering patients with a hospital stay of ≤ 30 and ≤ 20 days we noticed a significant difference in favor of ERAS protocol (p = 0.043, p = 0.004) with regards to hospital stay. Removal of single-J stents occurred on day 11 (8–17) in the non-ERAS group and on day 8 (8–15) in the ERAS group post-surgery (p < 0.001). No difference could be identified in overall and 90-day complication rate (p = 0.443).
Conclusion
Adherence to ERAS protocol achieved a significantly shorter hospital stay in patients with a hospital stay of ≤ 30 and ≤ 20 days with no increase in complication rates. Furthermore, early removal of single-J stents did not result in higher rates of postoperative complications and hospital readmission.
Effect of soy isoflavones on measures of estrogenicity: A systematic review and meta-analysis of randomized trials
Authors: Viscardi Gabrielle , Back Songhee , Ahmed Amna , Yang Shuting , Mejia Sonia Blanco , Zurbau Andreea , Khan Tauseef A , Selk Amanda , Messina Mark , Kendall Cyril WC , Jenkins David JA , Sievenpiper John L , Chiavaroli Laura
Published: February 2024

Background
Despite dietary recommendations to consume more plant foods for public and planetary health and the role that soy foods can play in plant-predominant diets, controversies around the effects of soy foods and their components, especially isoflavones, are a barrier to their intake. Given the cardioprotective effects and ability to alleviate menopausal symptoms, addressing this issue is particularly relevant to women. We therefore undertook a systematic review and meta-analysis of randomized controlled trials in postmenopausal women to determine the effect of soy isoflavones on measures of estrogenicity.
Methods
MEDLINE, Embase, and Cochrane Library were searched through July 2023 for randomized controlled trials 3-months investigating soy isoflavones versus non-isoflavone controls in postmenopausal women. The four outcomes included endometrial thickness (ET), vaginal maturation index (VMI), follicle-stimulating hormone (FSH), and estradiol. Independent authors extracted data and assessed risk of bias. GRADE (grading of recommendations assessment, development, and evaluation) was used to assess certainty of evidence.
Results
We included 40 trials (52 trial comparisons, n=3285) assessing the effect of a median daily dose of 75 mg of soy isoflavones in substitution for non-isoflavone control over a median of 24 weeks. Isoflavones had no statistically significant effects on any of the measures of estrogenicity; ET (mean difference, -0.22mm [95% confidence interval, -0.45 to 0.01mm], PMD=0.059), VMI (2.31 [-2.14 to 6.75], PMD=0.310), FSH (-0.02IU/L [-2.39 to 2.35IU/L], PMD=0.987), and estradiol (1.61pmol/L [-1.17 to 4.38pmol/L], PMD=0.256). The certainty of evidence was high-to-moderate for all outcomes.
Conclusion
Current evidence provides a good indication that soy isoflavones do not have an estrogenic effect versus non-isoflavone controls on 4 measures of estrogenicity in postmenopausal women. This synthesis supports the classification of soy isoflavones as selective estrogen receptor modulators and that isoflavones differ clinically from the hormone estrogen where no assumptions about the health effects of soy foods or isoflavones should be based on an understanding of the effects of the hormone estrogen. Addressing public health concerns around soy foods may support their intake as high-quality plant protein foods with low environmental impact and cost, especially relevant for postmenopausal women, and aligning with sustainable dietary patterns and guidelines.
Registration: PROSPERO (CRD42023439239)
The safety and efficacy of subcutaneous negative pressure drainage to close midline epigastric incision: a retrospective case-control study
Authors: Yuan Xie , xu rui , Yang chao , Xiao shuo-meng
Published: February 2024

Background
Incision complications were still a problem of open gastrectomy. Aim of this study was to assess the safety and efficacy of a method of closing incision, named subcutaneous negative pressure drainage.
Methods
A retrospective case-control study was designed to compare the safety and efficacy between subcutaneous suture and subcutaneous negative pressure drainage to close the midline epigastric incision. Clinical data of all the patients underwent open gastrectomy were collected. Characteristics of patients and incision complications were analyzed.
Results
From January 2015 to July 2023, 430 patients underwent subcutaneous suture and 456 patients underwent subcutaneous negative pressure drainage were included. There were not significantly differences between two groups in clinical characteristics. The rates of surgical site infection and non-infection complications were lower in the subcutaneous negative pressure drainage group.
Conclusion
Subcutaneous negative pressure drainage was safe and efficient. This approach should be recommended for closure of midline incision.