bluuebunny/crossref_metadata_2025 huggingface dataset:
Epileptic versus neuro-oncological focus of management in pediatric patients with concurrent primary brain lesion and seizures: a systematic review
Authors: Gruber Maxwell D. , Pindrik Jonathan , Damante Mark , Schulz Lauren , Shaikhouni Ammar , Leonard Jeffrey R.
Published: August 2023

OBJECTIVE

Seizures can be a debilitating manifestation of underlying neoplastic intracranial pathology. Existing literature offers a paucity of scientific consensus regarding risk factors, seizure semiology, operative techniques, and tumor characteristics in pediatric patients with a concurrent diagnosis of primary intracranial neoplasm and seizures. To address the limited evidence in current literature, the authors systematically reviewed published literature on current clinical characteristics and management strategies for patients presenting concurrently with seizures and a newly diagnosed brain lesion, while aiming to synthesize a potential management protocol or set of recommendations for these patients.

METHODS

An initial search revealed 792 papers, of which 196 studies were excluded, leaving 596 studies available for abstract review. After further stratification, 546 studies were eliminated, leaving 50 studies for eligibility assessment. Of the 50 studies, 12 met the criteria for outcome extraction.

RESULTS

The results indicate that patients with a mean age of 9 years with a newly diagnosed brain tumor and presenting symptoms of seizure are likely to present with daily seizures of the complex partial subtype, with the most likely primary epileptogenic and neoplastic foci occurring in the temporal lobe. The most common tumor subtypes were low-grade gliomas, ganglioglioma, dysembryoplastic neuroepithelial tumor, or astrocytoma. With the aim of gross-total resection, 77.54% of patients are likely to achieve seizure freedom.

CONCLUSIONS

This study highlights the demographic, clinical, seizure, tumor, and postoperative outcomes for pediatric patients presenting with a primary brain tumor and concurrent seizures. Further prospective multicenter studies are necessary to understand and compare varying treatment approaches and to develop standardized guidelines for these patients, with the goal of optimizing neuro-oncological and seizure-related outcomes.
Association between immunohistochemical markers and tumor progression following resection of spinal chordomas: a multicenter study
Authors: Ghaith Abdul Karim , Akinduro Oluwaseun O. , Perez-Vega Carlos , Bon Nieves Antonio , Abode-Iyamah Kingsley , Patel Naresh , Kalani Maziyar , Clarke Michelle J. , Rose Peter , Bydon Mohamad
Published: August 2023

OBJECTIVE

Chordomas are slow-growing tumors derived from notochord remnants. Despite margin-negative excision and postoperative radiation therapy, spinal chordomas (SCs) often progress. The potential of immunohistochemical (IHC) markers, such as epithelial membrane antigen (EMA), combined with machine learning algorithms to predict long-term (≥ 12 months) postoperative tumor progression, has been understudied. The authors aimed to identify IHC markers using trained tree-based algorithms to predict long-term (≥ 12 months) postoperative tumor progression.

METHODS

The authors reviewed the records of patients who underwent resection of SCs between January 2017 and June 2021 across the Mayo Clinic enterprise. Demographics, type of treatment, histopathology, and other relevant clinical factors were abstracted from each patient’s record. Low tumor progression was defined as more than a 94.3-mm3 decrease in the tumor size at the latest radiographic follow-up. Decision trees and random forest classifiers were trained and tested to predict the long-term volumetric progression after an 80/20 data split.

RESULTS

Sixty-two patients diagnosed with and surgically treated for SC were identified, of whom 31 were found to have a more advanced tumor progression based on the tumor volume change cutoff of 94.3 mm3. The mean age was 54.3 ± 13.8 years, and most patients were male (62.9%) and White (98.4%). The most common treatment modality was subtotal resection with radiation therapy (35.5%), with proton beam therapy being the most common (71%). Most SCs were sacrococcygeal (41.9%), followed by cervical (32.3%). EMA-positive SCs had a postoperative progression risk of 67%. Pancytokeratin-positive SCs had a progression rate of 67%; however, patients with S100 protein–positive SCs had a 54% risk of progression. The accuracy of this model in predicting the progression of unseen test data was 66%. Pancytokeratin (mean minimal depth = 1.57), EMA (mean minimal depth = 1.58), cytokeratin A1/A3 (mean minimal depth = 1.59), and S100 protein (mean minimal depth = 1.6) predicted the long-term volumetric progression. Multiway variable importance plots show the relative importance of the top 10 variables based on three measures of varying significance and their predictive role.

CONCLUSIONS

These IHC variables with tree-based machine learning tools successfully demonstrate a high capacity to identify a patient’s tumor progression pattern with an accuracy of 66%. Pancytokeratin, EMA, cytokeratin A1/A3, and S100 protein were the IHC drivers of a low tumor progression. This shows the power of machine learning algorithms in analyzing and predicting outcomes of rare conditions in a small sample size.
НАПРЯМИ ДОСЛІДЖЕННЯ СТРУКТУРНИХ ЗМІН НА ВНУТРІШНЬОМУ РИНКУ
Authors: ВАСИЛЬЦІВ Тарас , МУЛЬСКА Ольга , ГРЕСЬ Арсен
Published: August 2023

У дослідженні наголошено на об’єктивно існуючій потребі, а також проблематиці забезпечення ефективного державного управління структурними змінами та інституційними реформами на внутрішньому ринку. Метою дослідження визначено наукове обґрунтування напрямів дослідження структурних змін на внутрішньому ринку. Показано, що питання формування й реалізації регіональної економічної політики структурних реформ є критично актуальними, причому за всіх типів та фаз суспільного відтворення, коли за спаду економіки потребуються більш кардинальні зміни в її структурі, а на етапі зростання – орієнтовані на інноваційно-технологічну модернізацію, слідування трендам найбільш конкурентоспроможних і прогресивних лідерів. Визначено компоненти й напрямами структурного реформування регіональної економічної системи, а саме (1) формування оптимальної галузево-продуктової структури регіональної економіки; (2) становлення повноцінного інституційного середовища; (3) забезпечення раціонального й динамічного перебігу відтворювальних процесів; (4) збалансування секторальних пропорцій регіональної соціально-економічної системи; (5) активізація інноваційно-технологічного розвитку та його внеску у зміцнення конкурентоспроможності регіональної економіки.
Peran Perserikatan Bangsa-Bangsa Menangani Pelanggaran HAM dalam Konflik Suriah Tahun 2013-2018
Authors: Lubis Muhammad Rafli , Aswar Hasbi
Published: August 2023

Since 2011 the Syrian conflict has been going on until now and there is no sign that it will end. In the conflict that occurred, there were various violations committed by both rebel groups and the Syrian government itself. Various international actors have contributed to the conflict, whether in the mediation process, sending humanitarian aid, or condemning the violations that have occurred, but this has not been able to stop the conflict from occurring. This paper will try to analyze the role of the United Nations in the Syrian conflict by limiting it to 2013 – 2018. In this paper, the concept carried out in response to the enforcement efforts carried out by the United Nations in the Syrian conflict is to use the role of international organizations or the United Nations in upholding human rights through the monitoring process. , support and implementation of international human rights.
 
 
Sejak tahun 2011 konflik Suriah sampai saat ini dan belum ada tanda – tanda akan selesai. Dalam konflik yang terjadi tersebut, terjadi berbagai pelanggaran yang dilakukan baik kelompok pemberontak maupun pemerintahan Suriah sendiri. Berbagai aktor internasional sudah berkontribusi dalam konflik tersebut, baik dalam proses mediasi, mengirimkan bantuan kemanusiaan atau melakukan kecaman terhadap pelanggaran yang terjadi, namun hal itu tidak bisa menghentikan konflik yang terjadi. Tulisan ini akan mencoba menganalisa peran PBB dalam konflik Suriah dengan membatasi pada tahun 2013 – 2018.  Dalam tulisan ini konsep yang dilakukan dalam menanggapi upaya penegakan yang dilakukan oleh PBB di konflik Suriah adalah menggunakan peranan organisasi internasional atau PBB  dalam penegakan hak asasi manusia melalui proses pengawasan, dukungan, dan implementasi HAM internasional.
Data Rights di Era Surveillance Capitalism: Skandal Data Cambridge Analytica & Facebook dalam Pemilihan Presiden Amerika Serikat 2016
Authors: Bofa Maya , Wawan Budi Darmawan , Sudirman Arifin
Published: August 2023

In 2018, several major British media outlets published the result of a joint investigation which revealed that Cambridge Analytica, a political consulting and data analysis firm, collected about 87 million personal data of Facebook users which was then used without the knowledge of the data owner. This study aims to understand analyze the abuse of data rights involving Cambridge Analytica and Facebook in the 2016 US presidential election. The research method used in this study is descriptive qualitative method. This study found that Cambridge Analytica used personal data of Facebook users for Donald Trump’s digital campaign in the 2016 US presidential election. The data include complete profiles such as name, gender, age, location, status updates, likes, friends, and even personal messages which are then translated into behavioral data. The data collected and analyzed by Cambridge Analytica then became the power in modifying behavior, especially voting behavior. Behavior modification by Cambridge Analytica was possible because the knowledge asymmetry in the use of data.
 
Pada 2018, beberapa media besar Inggris mempublikasikan hasil investigasi bersama yang mengungkap bahwa Cambridge Analytica, sebuah perusahaan konsultan politik dan analisis data, mengoleksi sekitar 87 juta data pribadi pengguna Facebook yang kemudian digunakann tanpa sepengetahuan pemilik data. Penelitian ini bertujuan untuk memahami dan menganalisis penyalahgunaan data rightsyang melibatkan Cambridge Analytica dan Facebook dalam pemilihan presiden Amerika Serikat 2016. Adapun metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif. Penelitian ini menemukan bahwa Cambridge Analytica
menggunakan data pribadi pengguna Facebook untuk kepentingan kampanye digital Donald Trump pada pemilihan presiden Amerika Serikat 2016. Data yang diambil meliputi profil lengkap seperti nama, jenis kelamin, usia, lokasi, pembaruan status, likes, teman, bahkan pesan pribadi yang kemudian diterjemahkan menjadi behavioral data. Data yang dikumpulkan dan dianalisis oleh Cambridge Analytica kemudian menjadipower dalam behavioral modification, khususnya voting behavior. Modifikasi tingkah laku oleh Cambridge Analytica dapat dilakukan sebab adanya knowledge asymmetry dalam penggunaan data.
Perbandingan Sistem Wakaf Sebagai Implementasi Kebijakan Distribusi Sosial (Studi Kasus: Arab Saudi Dan Malaysia)
Authors: Muis Afni Regita Cahyani , Putri Mia Utami , Amalia Zahra , Khalifah Nanda Putri , Faatimah Faatimah
Published: August 2023

This article will explain the comparison of waqf systems in Malaysia and Saudi Arabia. Each country has a different waqf management system that supports social distribution policies. Malaysia is managed by the State Islamic Religious Council, as Malaysia is a federal country and each state has a Waqf Management Committee to manage waqf assets. Saudi Arabia is managed by a special institution called the Higher Waqf Council, chaired by the Minister of Hajj and Waqf, with the authority to distribute waqf assets according to the mandate given by the waqif. This study uses a comparative method by analyzing two objects which then result in similarities and differences in the waqf system to find social distribution policy factors and their implementation. This study uses a qualitative-descriptive method with secondary analysis, namely using secondary data such as journals and official websites. The results of this study show that the management of waqf is different in each organization in their respective countries and has different authorities, but the results still make waqf as one of the policies made by the government for their country.
 
Artikel ini akan menjelaskan perbandingan sistem wakaf di negara Malaysia dan Arab Saudi. Setiap negara memiliki sistem pengelolaan wakaf berbeda yang mendukung kebijakan distribusi sosial. Malaysia dikelola oleh Dewan Agama Islam Negara, karena Malaysia adalah negara federal dan setiap negara memiliki SIRC untuk mengelola wakaf. Arab Saudi yang dikelola oleh lembaga khusus yang disebut Majelis Tinggi Wakaf diketuai oleh Menteri Haji dan Wakaf, dengan kewenangan untuk mendistribusikan aset wakaf sesuai mandat yang diberikan oleh wakif. Penelitian ini menggunakan metode komparatif dengan menganalisis dua objek yang kemudian menghasilkan persamaan dan perbedaan sistem wakaf untuk menemukan faktor-faktor kebijakan distribusi sosial dan implementasinya. Penelitian ini menggunakan metode kualitatif-deskriptif dengan secondary analysis, yaitu menggunakan data sekunder, seperti jurnal-jurnal dan official website. Hasil dari penelitian ini adalah bahwa dalam pengelolaan wakaf yang dikelola oleh masing-masing organisasi di negaranya dan memiliki kewenangan yang berbeda-beda namun hasilnya tetap menjadikan wakaf sebagai salah satu kebijakan yang dibuat oleh pemerintah untuk negaranya.
Strikter Pazifismus oder Wahl Der Besten Alternative? Kommentar zu Pazifismus. Eine Verteidigung
Authors: Lumer Christoph
Published: August 2023

In seinem Buch Pazifismus. Eine Verteidigung verteidigt Olaf Müller einen relativ strikten Pazifismus, der im Ukrainekrieg keine militärische Hilfe an die Ukraine erlaubt ‐ trotz der Anerkennung, dass es sich um einen verbrecherischen Angriffskrieg handelt.
Müller kritisiert die beiden üblichen Begründungen für solch eine Position, den gesinnungsethischen und den verantwortungsethischen Pazifismus, und entwickelt seine eigene Version, den pragmatistischen Pazifismus.Der vorliegende Beitrag diskutiert Müllers Pazifismus
kritisch und gibt einen Ausblick auf eine bessere ethische Alternative, nämlich die wohlfahrtsethische begrenzte Optimierung. Müllers Anliegen ist zutiefst human. Seine Begründung ist differenziert, aber langwierig, verwickelt und unklar. Ein Teil dieses Beitrags besteht darin,
diese Begründung zu rekonstruieren und auf das Wesentliche zu reduzieren, um dann die essentiellen Elemente gezielter kritisch diskutieren zu k??nnen.
Memupuk Motivasi Kewirausahaan bagi Santri di Pondok Pesantren At-Tawasul Desa Mulyasari Cianjur Jawa Barat
Authors: Rifai Muhammad Sayyid , Karmilah Milah
Published: August 2023

Untuk meningkatkan kesejahteraan rakyat Indonesia, pembangunan sumber daya manusia harus dilakukan. Baik pendidikan formal maupun pendidikan informal digunakan untuk membangun sumber daya manusia. Pendidikan yang diberikan di Pondok Pesantren memiliki ciri khas khusus yang memungkinkan tim Pengabdian untuk melakukan kegiatan pelayanan dengan mendorong jiwa kewirausahaan para santri. Kegiatan pengabdian ini dilaksanakan dengan menggunakan metodologi pelatihan kewirausahaan. Pelatihan yang diberikan oleh tim layanan meliputi instruksi dalam mengenakan jilbab dan membuat masker organik. Pondok Pesantren At-Tawassul Cianjur Jawa Barat dipilih sebagai lokasi kegiatan pengabdian tersebut, dan dilakukan secara bertahap selama beberapa hari. Hasil dari kegiatan tersebut adalah motivator bagi siswa untuk memahami berbagai kegiatan kewirausahaan yang dapat mereka lakukan di luar pendidikan formal mereka. Untuk memaksimalkan hasil atau tujuan yang dicapai, tindakan ini harus dilanjutkan terus menerus.
Pengaruh DBH, DAU, DAK Terhadap Bd Di Kota, Provinsi Jawa Timur Tahun 2014-2021
Authors: Wulandari Novita , Hidayat Rahmad Wahyu , Fuddin Moh. Khoirul
Published: August 2023

The purpose of this study was to determine the effect of balancing funds, including revenue-sharing funds (ISF), general allocation funds (GAF), and special allocation funds (SAF) on regional expenditure per city in the city of East Java Province in 2014-2021. The analysis tool used is panel data regression. The results of the study show that the variables of profit-sharing funds, general allocation funds, and special allocation funds have a positive and significant influence on regional spending in the City of East Java Province.
Analisa Pengaruh Partial Media Sosialdanatribut Produk Terhadap Citra Merekserta Keputusan Pembelian “Jamur Mantan”
Authors: Murlinawati Apsari , Daroini Ahsin , Tiyas Ratna Dewi Mulyaning
Published: August 2023

Social media marketing is an online activity and program designed to engage businessman, customers or prospects and directly raise awareness, improve product attributes, establish a brand image, or gain product sales.The objectives of the study were (1) to determine the partial effect of social media (X1) and product attributes (X2) on the brand image (Y) of the “jamur mantan” snack and (2) to determine the partial of social media (X1), product attributes (X2) and brand image (Y) on purchasing decisions (Z) “jamur mantan” snack. Type of research is descriptive research with a quantitative approach. Data collection was carried out by distributing closed questionnaires with 5 Likert scales. Data were analyzed using SPSS, the tests conducted were validity, reliability and t test. Based on the results of the study, it was found that the validity and reliability tests were obtained that the instruments used were valid (rcount ≥ 0,3) and reliable (Cronbach's Alpha value ≥ 0,6. The results of partial hypothesis testing are that brand image is significantly affected by product attributes, while social media has no significant effect. Purchase decisions are significantly influenced by social media. Brand image has an effect on purchasing decisions but is not significant, while product attributes have no effect.
IMPLEMENTASI PEMBIMBINGAN DAN PENGAWASAN PK BAPAS TERHADAP PERUBAHAN PERILAKU KLIEN PEMASYARAKATAN YANG MELAKUKAN PELANGGARAN HUKUM KEMBALI (Studi kasus di Balai Pemasyarakatan Kelas II Kediri)
Authors: Setiasih Idha Wening , Nurbaedah Nurbaedah
Published: August 2023

The purpose of this study was to analyze the implementation of the guidance and supervision of Probation Officer according to Law Number 12 of 1995 concerning Corrections and Regulation of the Government of the Republic of Indonesia Number 31 of 1999 concerning the Coaching and Guidance of Correctional Assisted Citizens  against changes in the behavior of correctional clients who break the law again, to analyze the obstacles faced by the Probation Officer in guiding and supervising correctional clients who break the law again. The location of this study is the Class II Penitentiary (Bapas) Kediri which is located at Penanggungan street, no. 19, Kediri City, East Java, with a total of 13 respondents using the purposive sampling method with qualitative data analysis and data collection techniques using primary data and secondary data obtained by structured interviews, in-depth interviews, observation, and documentation. The result of this study is that the guidance and supervision of Probation Officer on the behavior of correctional clients has been effective as seen from Law Number 12 of 1995 concerning Corrections and Regulation of the Government of the Republic of Indonesia Number 31 of 1999 concerning the Coaching and Guidance of Correctional Assisted Citizens because almost all of these regulations have been carried out and implemented by the Probation Officer, However, when viewed from the behavior of correctional clients, the guidance and supervision of the Probation Officer has not been fully effective because there has been no change in the behavior of correctional clients who are still breaking the law.. The factors that become obstacles for the Penitentiary (Bapas) Kediri in carrying out guidance tasks for correctional clients are a) Penitentiary regulations, b) Penitentiary personnel, c) Infrastructure, d) Personal, from correctional clients and the family., and e) Cost.
TINJAUAN YURIDIS TERHADAP PEMBUKTIAN HARTA BERSAMA DALAM PUTUSAN NOMOR 0133/Pdt.G/2016/PA.Kdr
Authors: Kumala Nirvana Rifka Dian , Fahrazi Mahfud
Published: August 2023

This master thesis is about the joint property’s evidence of the verdict number 0133/Pdt.G/2016/PA.Kdr. The evidences that submitted by defendant counterclaim were an authentic deed and two witnesses who are siblings of the defendant counterclaim, so according to that the judges decided to share the joint property of marriage againts the Compilation of Islam Law Section 97. The purposes of this master thesis are to analyze the validity of the evidences in joint property’s evidence and to analyze the judge’s considerations of the verdict number 0133/Pdt.G/2016/PA.Kdr. This master thesis is a normative research. This master thesis concludes that the validity of the evidences in joint property’s evidence of the verdrict number 0133/Pdt.G/2016/PA.Kdr according to Section 145 of HIR, Section 172 of RBg and Section 1910 of Indonesian Civil Code, plaintiff counterclaim submitted an authentic deed and two witnesses as evidences so both of them were valid as evidences. And then the evidences that submited by defendant counterclaim were an authentic deed and two witnesses who are the siblings of defendant counterclaim, so that the two witnesses that submitted by defendant counterclaim does not fulfill the formal requirement of evidence based on the codes. The verdict does not fulfill the elements of legal certainty.
TINJAUAN YURIDIS TERHADAP PUTUSAN BEBAS VRIJSPRAAK TINDAK PIDANA ASUSILA DI PENGADILAN NEGERI JOMBANG (Studi Putusan Perkara Nomor: 131/Pid.B/2021/Pn.Jbg)
Authors: Ajikirana Shafir Karisma , Karyoto Karyoto
Published: August 2023

Penelitian ini berangkat dari maraknya kasus tindak pidana asusila yang terjadi di kabupaten jombang, terdapat satu kasus tindak pidana asusila yang mana hakim  memberikan putusan bebas terhadap terdakwa. Dari hal ini melahirkan rumusan masalah terkait apa yang menjadi pertimbangan hakim dalam memberikan putusan bebas dan bagaimana aspek keadilan terhadap putusan hakim. adapun metodologi penelitian yang digunakan pada penelitian adalah metode penelitian empiris dengan menggunakan pendekatan normatif, teknik pengumpulan data menggunakan wawancara dan kajian kepustakaan, sedangkan teknik analisis data menggunakan metode Induktif yaitu metode dari khusus ke umum. Hasil penelitian ini menunjukan bahwa jaksa penuntut umum hanya membacakan dakwaan ketiga dari total tiga dakwaan yang didakwakan kepada terdakwa, lalu kuasa hukum terdakwa memberikan pembelaan atau pledoi yang menitik beratkan pada dakwaan jaksa penuntut umum yang mana diperoleh bukti bahwa dalam kasus ini terdakwa tidak bisa didakwa atas dakwaan yang diberikan karna menurut kuasa hukum dakwaan tersebut tidak tepat dan hakim memberikan putusan bebas terhadap terdakwa atas pertimbangan tersebut.
Pengaruh Kepuasan Kerja dan Kompensasi Terhadap Turnover Rate Karyawan Hotel Feodora Airport Palembang
Authors: Arista Putri , Purnamasari Endah Dewi , Darma Putra Mohammad Kurniawan
Published: August 2023

This study aims to determine the effect of job satisfaction and compensation on the employee turnover rate of Hotel Feodora Airport Palembang. This research carried out on all employees using a saturated sample technique of 132 people. The primary data of this study were obtained through questionnaires and processed using a quantitative approach with the SPSS statistical test tool version 25.00 For Windows. based on results the research conducted found that the variable job satisfaction (X₁) and Compensation (X₂) has a negative and significant effect on the turnover rate Employees of Hotel Feodora Airport Palembang (Y). Linear regression test results is obtained the value of the coefficient of job satisfaction (X₁) of -0.786 and the value compensation regression coefficient (X₂) of -0.183 with a significance level of 0.000 < 0.05. T test results variable of job satisfaction (X₁) of -13.853 and compensation (X₂) of -4.113 with a significance level of 0.000 < 0.05 partially job satisfaction and compensation have a negative and significant effect on the turnover rate. The results of the F test obtained F count of 204.419 with the level significance of 0.000 < 0.05 which means that simultaneously job satisfaction (X₁) and compensation (X₂) have a negative and significant effect on the turnover rate.
Analisa Pengaruh Penerapan Absensi Melalui Disiplin Kerja Sebagai Variabel Intervening Terhadap Kinerja Pegawai Penyuluh Keluarga Berencana (Studi Kasus Dinas P3APPKB Kabupaten Blitar)
Authors: Saputro Aang Dwi , Arisyahidin Arisyahidin , Rusandy Deby Satyo
Published: August 2023

The purpose of this study was to determine the effect of implementing absenteeism on employee discipline and the performance of family planning extension workers at the P3APPKB Office of Blitar Regency partially, to determine the effect of work discipline on the performance of family planning extension officers at the P3APPKB Office of Blitar Regency and to determine the effect of implementing absenteeism through discipline. Work as an Intervening Variable on the Performance of Family Planning Extension Officers at the P3APPKB Office of Blitar Regency. The population in this study were all employees of the Blitar Regency P3APPKB Office, totaling 79 employees. Based on the calculation of the number of samples using the slovin formula, a sample of 66 respondents was obtained. The data analysis technique used in this research is SmartPLS-SEM. The results of the study show that 1) Absenteeism has an effect on the Discipline of Family Planning Extension Officers at the P3APPKB Office of Blitar Regency; 2) Absence does not affect the performance of Family Planning Extension Officers at the P3APPKB Office of Blitar Regency; 3) Work Discipline has an impact on the Performance of Family Planning Extension Officers at the P3APPKB Office of Blitar Regency; 4) Application of Absence through Work Discipline as an Intervening variable affects the Performance of Family Planning Extension Employees at the P3APPKB Office of Blitar Regency.
Pengaruh Kepemimpinan Instruksional, Disiplin Kerja dan Konflik Kerja Terhadap Kinerja Guru MTsN 1 Blitar
Authors: Sochifu Eryda , Mutiara Nisa , Askafi Eka
Published: August 2023

In the Decree of the Minister of Religion 633 of 2020 concerning Bureaucratic Reform of the Ministry of Religion, it is stated that one of the programs is Human Resources which aims to create clean, professional and responsible apparatus through employee management by implementing a competency-based Human Resources management system. The research objective is a description of the answer you want to know, Sugiyono revealed that the research objective is so that data can be found, developed, and proven. Meanwhile, the results of the research will obtain new knowledge so that it can be used to understand, solve, and anticipate problems. The purpose of this research is to analyze the simultaneous influence of instructional leadership, work discipline and work conflict on teacher performance at Madrasah Tsanawiyah Negeri 1 Blitar. Based on the problems discussed in this study, the researcher used a quantitative approach, the value of the Anova F Test: 53,286 with Sig F Test: 0.000 <0.05 So there is a simultaneous influence of the independent variables on the dependent variable or H0 is rejected and H1 is accepted. Sig. Value the value of R Square and adjusted R Square, if it is close to 1, the greater it can explain the dependent variable (Y). The R value or multiple correlation is 0.857, the R Square is 0.734 with the Adjusted R Square value: 0.720 > 0.5 indicating that a set of independent variables can strongly explain the dependent variable, and is significant because the simultaneous test rejects H0. The magnitude of the effect is 72%, and the remaining 100% -72% = 28% is explained by other variables outside the model.
Colo Uterino — 1ª parte: notas de nomenclatura conceito de terceira mucosa
Authors: Barcellos José Maria , Freire Nazaré Serra , Castellar Dulce , Borges Virgínia , Nahoum Jean Claude
Published: August 2023

Dispersos na literatura especializada, vários trabalhos vislumbravam muito de errado nos conceitos clássicos de fisiopatologia cervical. Todavia, o conhecimento preciso e a divulgação que renovariam os estudos do colo do útero, deveram-se entre nós, a Duarte (1953-55-58 e 60) e aos autores germânicos HamperI, Ober, Kaufmann & Schneppenheim (1958-59). A noção dinâmica da histologia cervical veio abalar velhos conceitos da patogenia das cervicites e da histogênese dos carcinomas.
Organization of Radiation Medicine
Authors: Gomez-Crespo G.
Published: August 2023

Castigat ridendo mores “Radiation medicine comprises three distinct branches: diagnostic radiology, radiotherapy and nuclear medicine. These three branches have become separate and distinct specialties in medicine but are linked together under the term radiation medicine because they have various features in common. They make use of the diferente properties of ionizing radiations; there are certains hazards which need the same principies of protection and call for the same basic training in the use and hazards of ionizing radiation; they need purpose built accommodation which has some features in common; they need the expert Services of specially trained physicists and of technicians whose training has some common features".
Câncer de Mama: Estudos de Mortalidade
Authors: Laurenti Ruy
Published: August 2023

Por meio das estatísticas oficiais de mortalidade é possível caracterizar os padrões de mortalidade por câncer de mama observados em diferentes países; assim, tem sido verificado que nos Estados Unidos, Canadá e em grande número de países europeus o câncer de mama é a localização mais freqüente, quanto aos tipos de neoplasias malignas mortais, no sexo feminino. A análise da mortalidade por câncer de mama, segundo grupos etários, mostra que aumenta com a idade, porém esse aumento é muito maior até os 40 a 45 anos e a partir desta idade o aumento não é tão acentuado.
Epidemiologia do Câncer de Mama
Authors: Mirra Antônio Pedro
Published: August 2023

Na epidemiologia analítica do câncer de mama procuramos, baseados na observação, examinar as hipóteses formuladas a partir de estudos descritivos.
Pharmacological evaluation and preclinical studies of hypochlorous acid solution
Authors: Brezvyn O. M. , Kotsiumbas I. Ya. , Velichenko O. B. , Shmychkova O. B. , Luk'yanenko T. V. , Girenko D. V. , Dmitrikova L. V.
Published: August 2023

The article presents materials on the electrochemical synthesis of hypochlorous acid and its pharmacological and toxicological evaluation. In the market of veterinary drugs, special attention has been paid to long-known, potent detoxifying antimicrobial agents based on active oxygen obtained by the electrolysis method. In addition to a broad spectrum of antimicrobial action, such drugs have several other advantages, especially the biogenic nature, which causes the absence of allergic reactions. New electrocatalysts were proposed for the electrochemical synthesis of hypochlorous acid, which was produced according to the following method using a combined electrochemical-pyrolytic method. VT1-0 technical titanium was used as a current collector. The current collectors were subjected to several preliminary preparation steps, such as NaOH degreasing and etching in 6 M HCl. Initial nanotubes were obtained by anodizing Ti foil in ethylene glycol with 0.3 wt.% ammonium fluoride and 2 vol.% water for 4 hours. The electrochemical reduction was carried out in 1 M HClO4 by cathodic polarization for 1 hour. Later, a thin discontinuous layer of platinum or consecutive layers of platinum-palladium were applied to the base by electrodeposition. Nitrite electrolytes for platinization and phosphate-palladation were used for this purpose. Depending on the task, platinum, and palladium on the ground's surface varied from 0.1 to 2.0 mg/cm2. The obtained material was heat-treated in an air atmosphere. At this stage, the surface layers of composites were formed due to the oxidation of the base and encapsulation of platinum and palladium particles in titanium oxide. It was established that the solution of hypochlorous acid, obtained by the electrolysis method, is a low-hazard substance that belongs to the fourth class of toxicity. Its half-lethal dose (DL50) is not determined. The fact that, in nature, hypochlorite acid is formed by granulocytes of neutrophils involved in the last link of phagocytosis confirms that the resulting solution is low-toxic, environmentally safe, and incapable of causing side effects and distant consequences. The obtained results proved the perspective of using new technology for producing hypochlorite acid for veterinary medicine; its development is highly relevant, clinically expedient, and economically justified.
The effects of prevention as a competence fixation criterion and its impact on the impartiality of the judge
Authors: Terçarolli André Fini
Published: August 2023

The present study aims to analyze the effects, even if unintentional, arising from the fixation of jurisdiction by precedence in criminal proceedings due to the judge’s connection to the preliminary investigative phase for the criminal action. During the preliminary investigation stage, the judge is called upon to make a series of decisions and comes into contact with unilaterally produced pieces of information without adversarial process, circumstances that lead to a greater predilection for the theory being constructed. Factors that have the potential to impact the subsequent procedural phase due to the judge’s closer proximity to those terms, resulting in a rejection of arguments presented by the opposing party, even if not by their own choice. After analyzing the issues involving precedence and its impact on the impartiality of the judge, an attempt is made to propose a solution to mitigate its negative effects.
Hipertensão pulmonar tromboembólica cronica: revisão de literatura
Authors: Cavalcante Rômulo Coelho , Matos Luís Carlos Vieira , Lima Rodrigo Guimarães , Passos Raphael Lanza e
Published: August 2023

A Hipertensão Pulmonar Tromboembólica Crônica (HPTEC) é uma enfermidade grave e debilitante, a qual gera sequelas que impactam diretamente na qualidade e sobrevida de seus portadores. Causada por oclusão parcial do leito arterial da vasculatura pulmonar, êmbolos hemáticos e travas fibróticas geram um aumento progressivo da Resistência Vascular Pulmonar (RVP) e Pressão Média de Artéria Pulmonar (PmAP). Ademais, acredita-se que o hiperfluxo dessas regiões possam desencadear uma disfunção endotelial, com consequente remodelamento vascular. Como resultante dessas alterações hemodinâmicas, surge a Hipertensão pulmonar e insuficiência de Ventrículo Direito, sendo esta a principal causa de morbimortalidade associada a doença. Desde que diagnosticados precocemente e referenciados a centros especializados, seus portadores estão sujeitos a cura através da Tromboendarterectomia Pulmonar. Aos pacientes com risco proibitivo a cirurgia, outras alternativas como a Angioplastia Pulmonar por Balão estão disponíveis, além do seu tratamento farmacológico. Novos estudos são necessários para solidificar as evidencias e refinar o tratamento de portadores de HPTEC. Esta revisão de literatura tem por objetivo discutir acerca da fisiopatogenia, aspectos clínicos, propedêutica e modalidades terapêuticas disponíveis para HPTEC.
СТРАТЕГІЧНІ ВЕКТОРИ РОЗВИТКУ ЦИФРОВИХ РИНКІВ З ПОЗИЦІЇ АДВОКАЦІЇ ІНТЕРЕСІВ СПОЖИВАЧІВ
Authors: Смерічевський Сергій , Поканевич Юрій
Published: August 2023

У статті проаналізовано стратегічні вектори розвитку цифрових ринків з позиції адвокації інтересів споживачів. Визначено основні тренди, що впливають на трансформацію цифрових ринків. Проаналізовано тенденції зміни основних показників діяльності Антимонопольного комітету України. Визначено, що адвокатування економічної конкуренції націлене на досягнення позитивних аспектів у конкуренції. Проаналізовано основні підходи до визначення сутності поняття «адвокація у конкуренції». Обґрунтовано систему стратегічних заходів в контексті реалізації адвокації у конкуренції в Україні в умовах розвитку цифрових ринків. Визначено стратегічні вектори розвитку цифрових ринків з позиції адвокації інтересів споживачів в умовах інтелектуалізації та цифровізації. Обґрунтовано, що адвокація є важливою ініціативою для забезпечення позитивних наслідків у конкурентному середовищі. Посилення співпраці між державою, бізнесом та науково-технічними установами сприятиме збалансованому розвитку цифрових платформ і підтримці їхнього позитивного впливу на економіку країн світу.
ІННОВАЦІЇ В ТОВАРНІЙ ПОЛІТИЦІ: ВПЛИВ НА МАРКЕТИНГОВІ СТРАТЕГІЇ ТА КОНКУРЕНТОСПРОМОЖНІСТЬ
Authors: Холодний Геннадій , Холодна Юлія
Published: August 2023

У статті розглянуто актуальні проблеми ефективності сфери товарної політики, пов’язані з впровадженням інноваційних рішень та їх впливом на формування маркетингових стратегій та конкурентоспроможності підприємств. Визначено, що інтенсифікація темпів розвитку технологій та динаміки зміни споживацьких уподобань вимагає від суб’єктів господарювання не лише функціональної адаптації до нових умов, але й активного впровадження найновіших інноваційних рішень у власну товарну політику. Розглянуто сучасні інноваційні рішення, що застосовуються в товарній політиці підприємств. Досліджено поняття інновацій у контексті товарів та послуг, розглянуто їх конкретні види та основні характеристики. Визначено ключові переваги застосування інноваційних рішень у сфері формування товарної політики підприємств, такі як покращення якості продукції, забезпечення конкурентних переваг суб’єкта господарювання, залучення нових клієнтів та розширення ринкових можливостей.
Peran Pendidikan Dan Bimbingan Konseling Terhadap Pengembangan Dan Validasi Skala Ketahanan Karir
Authors: Isriyah Mudafiatun , Nurhayati Yanti , Awlawi Addahri Hafidz , Sukatno Sukatno , Isroani Farida
Published: August 2023

This study aims to develop and validate a career resilience scale to measure the level of career resilience in adult workers. The study was conducted through quantitative research methods involving 405 adult workers of Mustikatama factory workers in Lumajang, East Java. The developed scale is called CARE-NP (Courage, Adaptability, Resilience, Efficacy, Networking, Proactive) and was validated through content validity, construct validity, and reliability stages. The collected data were analyzed using statistical techniques such as exploratory factor analysis, confirmatory factor analysis, and correlation coefficient. The results showed that the CARE scale met the expected validity and reliability criteria. This study concludes that the CARE scale can be used to measure the level of career resilience in adult workers with good validity and reliability. This study makes an important contribution in expanding the understanding of career resilience and enabling guidance and counseling professionals to provide more effective services in helping individuals build better career resilience.
The Mechanism of Management of Transport Enterprises on the Basis of the Conception of Lean Production
Authors:   State University of Infrastructure and Technology, Sorokun Yuliia S.
Published: August 2023

The article is aimed at forming a mechanism for managing activity of transport enterprise on the basis of the conception of lean production. In the current economic conditions, the overwhelming majority of managers of domestic transport enterprises are aware that in order to effectively fight for consumers and maintain the desired level of competitiveness, modernization of all aspects of economic activity is necessary, in particular: reducing production costs, improving the level of product quality, reducing the time for the process of mastering new types of technologies, and improving the customer service process. One of the effective management approaches aimed at achieving these goals is the conception of lean production. As result of the study, it is allocated that the leading goal of the conception of lean production is to eliminate all types of losses and efficient use of material, financial and labor resources through continuous improvement of all business processes of enterprise aimed at meeting the needs of consumers by introducing lean production tools. Formation of an effective and market-compliant mechanism for managing the activities of a transport enterprise based on the conception of lean production is an objective need to ensure the effective development of enterprises in the current conditions. The author proposes her own definition of the concept of mechanism of management of activity of transport enterprise on the basis of the conception of lean production): it is a complex system that combines goals, principles, purpose, means and tools of introduction of lean production to increase management efficiency and achieve the effect (result) of creating a culture of continuous improvement of the quality of transport services, as well as improving the indicators of the level of economic efficiency of the transport enterprise. The mechanism of management of the transport enterprise on the basis of the conception of lean production involves the formation of a conception at the enterprise, which defines the goals, principles and purpose that affect the choice of tools for lean production, the use of which will increase the efficiency of management of the transport enterprise, which, in turn, affects the result of activities in general. Prospects for further research in this direction are the assessment of the effect or result of the introduction of the mechanism of management of the transport enterprise, in particular, the quality of transport services and improvement of indicators of the level of economic efficiency of the transport enterprise.
Project Management in a Global Context: The Cultural Aspects and Adaptation
Authors:   Zhytomyr Ivan Franko State University, Kalinichenko Olena O. , Mosiichuk Iryna V. ,   Zhytomyr Ivan Franko State University, Poyta Iryna O. ,   Zhytomyr Ivan Franko State University
Published: August 2023

The article is aimed at considering project management in a global context with a focus on cultural aspects and adaptation, i. e., to emphasize the importance of taking cultural aspects into account when managing projects in a global context. As a result of the study, the latest research and publications on project management in a global context are allocated. The purpose of management and project priorities are defined. The key stages of project management, as well as the main project participants, which can vary depending on its size, complexity and nature, are disclosed. It is substantiated that the successful implementation of the project requires cooperation and interaction of different participants who have their own responsibilities and roles. It is determined that understanding and taking into consideration cultural peculiarities become key factors for the successful implementation of the project in the global environment. The main cultural aspects in project management in a global context are disclosed. As a result of the study, it is proved that some cultures can emphasize individualism and independence, while others can emphasize collectivism and communion. It is found that successful project management requires consideration and adaptation to the diversity of cultures that affect the ways of communication, decision-making, organization of work and interaction with project participants. The article provides key aspects to be taken into account when adapting a project, which will help ensure the successful implementation of the project in a global context, thinking of the specific needs and requirements of the international environment. Prospects for further excursions in the direction of project management in a global context with a focus on cultural aspects and adaptation are important for the further development of this area. One possible direction of research could be to study more deeply the impact of cultural differences on the success of projects in a global context. This may include analyzing the impact of different cultural values, norms and practices on communication, decision-making and cooperation between project participants from different countries.
Accounting similarities, sophisticated investors, relevance and information asymmetry
Authors: Azarberahman Alireza , Pakdelan Saeed , Tohidinia Malihe
Published: August 2023

Information asymmetry is a phenomenon in the capital market that can be caused by various factors. The purpose of this paper is to contribute to the debate on whether information asymmetry can be affected by factors such as accounting comparability, sophisticated investors, and relevance, and therefore, its value-relevance for decision-making. The paper uses three methods criteria for information asymmetry (VOLTRADE, PNSY and bid-ask spread) as well as two methods for measuring accounting comparability (text mining and De-Franco). Therefore, it is feasible   to test and compare different methods of accounting comparability with different methods of information asymmetry. The results of the study indicate that the comparability of accounting practises has a notable adverse impact on information asymmetry. Additionally, it was observed that sophisticated investors have the ability to moderate this relationship. We find that relevance has significant relation with information asymmetry. Furthermore, it has been determined that comparability exerts a substantial influence on information asymmetry within an imperfectly competitive market, as opposed to a market characterised by perfect competition. Therefore, these findings underscore the significance of considering market conditions and competition levels in the issue. Ultimately, our findings indicate that the cash flow component of comparability exerts a notable impact on information asymmetry, in contrast to the accrual component. This study provides new insights regarding the nexus between accounting comparability and financial asymmetry.