bluuebunny/crossref_metadata_2025 huggingface dataset:
POSTMODERN GİYİM MODASINDA PARODİ KAVRAMI
Authors: Demir Parlak Sevda
Published: June 2022

Postmodern süreçte sanat ve tasarım alanında yapılan çalışmalarla, toplumsal değerler sistemi sorgulanarak yeni bir görsel etik benimsenmiş ve keskin sınırlar azalmaya başlamıştır. Yüksek kültür ve kitle kültürü arasındaki mevcut hiyerarşik ayrımın kaybolmasıyla, diğer sanat disiplinlerindeki gibi moda tasarımında da yeniden üretim etkin olmuş ve eklektizmle harmanlanan kodlar, üslup melezliği yaratmıştır. Moda çalışmalarında, eklektik ögelerin kullanımıyla farklı disiplinlerde de kendisine geniş bir uygulama alanı bulan parodi kavramının öne çıktığı görülmektedir. Postmodern dönemde yapılan giyim modası alanındaki tasarımlarla, tarz eklektizminin dinamik ögeleri arasında yer alan parodi terimine yeni anlamlar yüklenmiş ve moda tarihinde yer edinen spesifik formlar, yeniden üretimle işlevlendirilmiştir. Bu makalede, günümüz giyim modasında öne çıkan parodi kavram ve üslubunun araştırılması amaçlanmıştır. Çağdaş giyim modası tarihinde bu yaklaşımı benimseyen tasarımcılar ve çalışmaları tespit edilerek, kullanım amaçları sorgulanmış ve karakteristik örnekleri irdelenmiştir. Seçilen örnekler, atıfta bulunulan öncel kaynakla birlikte değerlendirilmiş, tasarımcıların tasarım felsefeleri ve parodi üslubunun kullanım nedenlerinden doğan sonuçlar belirtilmiştir.
Ohmic heating application in food processing: Recent achievements and perspectives
Authors: Jafarpour Dornoush , Hashemi Seyed Mohammad Bagher
Published: June 2022

Food processing is an important operation in the food industry that converts fresh foods into final products with desirable characteristics for consumption and storage. Ohmic heating is an emerging technique for food processing that seems to be a suitable alternative to conventional heat treatment. Recently, there has been a lot of research into ohmic heating applications in processing various foods.

This review highlights the findings of studies conducted in 2018–2022 on the impact of ohmic heating on the physical, chemical, and sensory properties of foodstuffs during processing. We found that this technology provides more reliable process control compared to the traditional technique, namely conventional heating. Although ohmic heating has a positive effect on the quality of foods, its efficiency is limited by certain food components, including acid and fat, that markedly affect the electrochemical attributes of foods.

Therefore, to achieve optimal results, ohmic heating conditions should be set in accordance with the properties of food materials. There is a need for further in-depth studies on the performance of ohmic heating in food processing on a large, rather than a lab scale.
Effects of spray-drying parameters on physicochemical properties of powdered fruits
Authors: Pui Liew Phing , Lejaniya Abdul Kalam Saleena
Published: June 2022

This review features different powdered fruits with optimal storage stability and physiochemical parameters. Spray-drying parameters, such as temperatures and flow rate, can affect the physical properties of powders. Carrier agents provide powders with various favorable qualities, e.g. good flow rate. Commercial spray-drying of fruit juice knows different carrier agents.

The review involved scientific and methodological publications, conference papers, patents, regulatory papers, and Internet resources. They were subjected to grouping, categorization, comparative analysis, and consolidation.

Inlet temperature, maltodextrin concentration, and air flow rate of spray-drying increased the powder yield but decreased the moisture content. Inlet temperature, maltodextrin concentration, and feed flow rate affected the solubility. Effects of atomization rate, air flow rate and free flow rate were assessed in terms of yield, moisture content, hygroscopicity, and solubility.

The article introduces the fundamentals of spray-drying and describes the effect of each spray-drying parameter on the powder quality. The list of parameters included inlet air temperature, atomization rate, air flow, and feed flow rate. We also evaluated the impacts of various carrier agents on the powder quality. The article contributed to a better understanding of how variable parameters affect the quality of food powders. The results provide the food industry with better choice options to adopt certain parameters for specific production needs.
Effect of rigid, bank vegetation on velocity distribution and water surface profile in open channel
Authors: Eraky Ola Mohamed , Eltoukhy Mahmoud Ali R. , Abdelmoaty Mohamed S. , Farouk Elzahry
Published: June 2022

The effects of rigid ditch bank vegetation on velocity distribution and water surface profile in trapezoidal open channels were investigated. Forty-eight tests were used to study the impacts of different vegetation densities. Tests were run for three vegetation densities (1,600, 400, and 178 stems/m2) along a fixed, 4.00 m reach, against four different discharges, each with three different depths. The measured water levels and velocities were analyzed and it was found that increasing the vegetation density increased the water depth upstream of the vegetated reach. while lowering it within it, when compared to the unvegetated case. The water's velocity profile as a ratio to the unvegetated case (V/u) is sigmoid, i.e., the maximum velocity (V/u) max occurs in the lower half of the water column, increasing shear stress near the bed, and, in turn, the likelihood of bed erosion along the vegetated channel's centerline. V/u increased with increasing vegetation density and Fro. A multiple regression analysis was done to assess the impact of ditch bank vegetation density on flow parameters.
ALGUNAS OBSERVACIONES SOBRE EL PROBLEMA DE LA UNIÓN DEL CUERPO Y EL ALMA EN DE ANIMA, DE ARISTÓTELES
Authors:   Universidad San Sebastián, Concepción, Chile, García Larraín Federico
Published: June 2022

Si se consideran el alma y el cuerpo como dos entidades de naturaleza diversa, surge el problema de cómo pueden estar unidas. Aristóteles intenta resolver este problema aplicando su distinción entre materia y forma al cuerpo vivo; el alma sería la forma que da el ser a la sustancia que es el cuerpo material. Sin embargo, para el caso del alma humana surge una dificultad: pareciera que, por sus operaciones, el alma humana tiene cierta independencia de la materia. Esto acercaría a Aristóteles a la posición dualista (platónica) que intentaba refutar. En este trabajo proponemos que, aunque Aristóteles no logra resolver el problema de la unión alma-cuerpo para el caso del hombre, su filosofía se hace cargo de todos los datos observables sin reducirlos a su teoría, y eso constituye un avance en la comprensión del problema.
Hsa_circ_0000437 Inhibits the Development of Endometrial Carcinoma
through miR-626/CDKN1B Axis
Authors: Li Xiaojuan , Liu Yahong
Published: June 2022

Background:

Circular RNAs (circRNAs) are pivotal in cancer biology. Nevertheless, the biological functions of circular RNA hsa_circ_0000437 (circ_0000437) have not yet been elucidated.

Introduction:

In the present study, we studied the expression characteristics of circ_0000437 in endometrial carcinoma (EC) and explored the roles and potential mechanisms of circ_0000437 in EC progression.

Methods:

Quantitative real-time polymerase chain reaction (qRT-PCR) was adopted to detect the expressions of circ_0000437, microRNA-626 (miR-626) and cyclin-dependent kinase inhibitor 1B (CDKN1B) in EC tissues and cells. 5-Ethynyl-2'-deoxyuridine (EdU), cell counting kit-8 (CCK-8) and Transwell assays were performed to evaluate EC cell proliferation and invasion. The expressions of CDKN1B and epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin and N-cadherin) were detected by Western blot. Moreover, the targeted relationship between miR-626 and circ_0000437 or CDKN1B was determined by dual-luciferase reporter and RNA immunoprecipitation (RIP) assays.

Results:

Circ_0000437 expression was reduced in EC tissues, and the low expression of circ_0000437 was positively correlated with the lymph node metastasis and high TNM stage of EC patients. Knocking down circ_0000437 promoted the proliferation, invasion and EMT of EC cells. Circ_0000437 directly targeted miR-626 and negatively modulated miR-626 expression in EC cells. CDKN1B was identified as the downstream target of miR-626 in EC cells. Besides, CDKN1B overexpression or miR-626 knockdown reversed the effects of knocking down circ_0000437 on EC cells.

Conclusion:

Circ_0000437 regulates the miR-626/CDKN1B pathway to suppress the proliferation, invasion and EMT of EC cells. This indicates that circ_0000437 may be a promising biomarker and therapy target for EC.
Microbiota-Gut-Brain Axis in Neurological Disorders: From Leaky Barriers
Microanatomical Changes to Biochemical Processes
Authors: Boschetti Elisa , Neri Irene , Follo Matilde Yung , De Giorgio Roberto , Cocco Lucio Ildebrando , Manzoli Lucia , Ratti Stefano
Published: June 2022

Background:

The gastrointestinal tract and the central nervous system are distinct because
of evident morpho-functional features. Nonetheless, evidence indicates that these systems
are bidirectionally connected through the gut-brain axis, defined as the signaling that takes place
between the gastrointestinal tract and central nervous system, which plays in concert with the gut
microbiota, i.e., the myriad of microorganisms residing in the lumen of the human intestine. In
particular, it has been described that gut microbiota abnormalities, referred to as dysbiosis, may
affect both central nervous system development and physiology.

Objective:

Starting from the possible mechanisms through which gut microbiota variations were
found to impact several central nervous system disorders, including Autism Spectrum Disorder
and Alzheimer’s Disease, we will focus on intriguing, although poorly investigated, aspects such
as the epithelial and vascular barrier integrity. Indeed, several studies suggest a pivotal role of gut
microbiota in maintaining the efficiency of both the intestinal barrier and blood-brain barrier. In
particular, we report evidence indicating an impact of gut microbiota on intestinal barrier and
blood-brain barrier homeostasis and discuss the differences and the similarities between the two
barriers. Moreover, to stimulate further research, we review various tests and biochemical markers
that can be used to assess intestinal and blood-brain barrier permeability.

Conclusion:

We suggest that the evaluation of intestinal and blood-brain barrier permeability in
neurological patients may not only help to better understand central nervous system disorders but
also pave the way for finding new molecular targets to treat patients with neurological impairment.
Recent Developments in Nano-Formulations Against Diabetes
Authors: Patra Prasun , Choudhury Swaralipi
Published: June 2022

Diabetes mellitus (DM) is a life-threatening metabolic syndrome, but patient compliance is poor due to the pain and inconvenience caused by the subcutaneous injection of insulin and other macromolecular diabetic therapies. Current challenges in DM management are to optimize the use of available therapies and reduce complications. For clinical improvements, future therapies need to be easier to use, achieving tighter glycemic control, better safety profiles, and reduced manufacturing costs. The medical applications of nanotechnology are enormous and have been proven to be the best approach to improve compliance and clinical efficacy by overturning biopharmaceutical obstacles. Nanoformulations enhance the properties of conventional drugs and are specific to the targeted delivery site. The aim of the present review is to provide an overview of the application of nano-formulations in diabetes management. We analyze the current state of most of the available approaches which are in various stages of research and development. Herein, we review the developing role of nanotechnology in diabetes management and focus on the technologies that we feel are most likely to have an impact.
Formulation Optimization and Evaluation of Nanocochleate Gel of
Famciclovir for the Treatment of Herpes Zoster
Authors: Kanugo Abhishek , Deshpande Ashwini , Sharma Rahul
Published: June 2022

Background:

Herpes zoster is a viral infection triggered due to the reactivation of the varicella-
zoster virus in the posterior dorsal root ganglion. Herpes zoster infections occur mostly in the facial,
cervical and thoracic regions of the body, beginning with pain and resulting in the vesicular eruption.
Recently, this infection was observed during the Covid-19 pandemic and also after the induction
of mRNA-based vaccine for coronavirus at an extended level. Nanocochleates are cylindrical (cigarshape)
microstructure lipid-based versatile carriers for drug delivery systems. Famciclovir is an antiviral
agent employed for the treatment of Herpes zoster infections.

Objective:

The current research aims to develop a novel nanocochleate gel of Famciclovir for the
treatment of herpes zoster infections with higher efficacy.

Methods:

The interaction studies using FTIR were carried out and indicated no such interactions between
the drug and lipids. The nanocochleates were developed using hydrogel, trapping, liposome before
cochleate dialysis, direct calcium dialysis and binary aqueous-aqueous emulsion methods, respectively.
The 32 Box-Behnken design was applied by considering the concentration of lipids (phosphatidylcholine
and cholesterol) and speed of rotation as independent factors, whereas particle size and entrapment
efficiency as dependable factors.

Results:

The developed nanocochleates were estimated for the particle size (276.3 nm), zeta potential
(-16.7 mV), polydispersity index (0.241), entrapment efficiency (73.87±0.19 %) and in-vitro diffusion
release (>98.8 % in 10 h). The optimized batch was further converted into the topical gel using carbopol
940 as a gelling agent. The prepared gel was smooth, rapidly spreadable with a viscosity (5998.72
cp), drug content (95.3 %) and remained stable during stability studies.

Conclusion:

A novel nanocochleate gel of Famciclovir was successfully developed for the treatment of
infections associated with Herpes Zoster with sustained release action.
Influence of Solid Particles on Wellbore Parameters in Solid Fluidization Production Process
Authors: Tang Liang , Liu Yang
Published: June 2022

Objective:

To efficiently exploit the hydrate reservoir, based on the problem of a large
amount of sand production in the current hydrate reservoir exploration process, combined with the solid
fluidization well testing and production method.

Methods:

A gas-liquid-solid three-phase flow model is established and hydrate decomposition is taken
into consideration. The changes in parameters of wellbore pressure, gas volume fraction, liquid volume
fraction, temperature and the decomposition rates of wellbore hydrate under the conditions of different
rates of sand production are analyzed.

Results:

The results show that with the increasing rate of sand production during the solid fluidization
well testing and production, the pressure of the wellbore is lifted, gas volume fraction declines, liquid
volume fraction declines, and the temperature of the wellbore does not change. Moreover, increasing
the rate of sand production also leads to the delay of the position where hydrate begins to decompose.

Conclusion:

With the decrease in hydrate saturation, the pressure of the wellbore goes up, gas volume
fraction is lifted, solid volume fraction rises, and decomposition rate of hydrate declines.
Fashioning ‘Belgian’ Literature and Cultural Mediatorship in the Journal littéraire et politique des Pays-Bas autrichiens (1786)
Authors: Vanacker Beatrijs , van Hooijdonk Charlotte , Van Puyvelde Vanessa , Verschaffel Tom
Published: June 2022

The present study re-examines the underexplored region of the eighteenth-century Southern Netherlands as a multilingual contact zone, one that is open to and affected by numerous transfers from neighbouring, more established cultures through the mediation of various actors. Embedded in a larger project on (literary) journals and their role in the shaping of a proto-Belgian literature before 1830, this article presents the case study of a short-lived Brussels periodical, founded by the French émigré Jean-Baptiste Lesbroussart (1747–1818). With his Journal littéraire et politique des Pays-Bas autrichiens (1786), Lesbroussart created a literary journal that presented itself as fundamentally reader-oriented. By taking into consideration Lesbroussart’s agency as a cultural mediator, we lay bare three levels of mediation informing his Journal: (1) his institutional mediatorship, or the entanglement of the networks in which he was involved, his intended readership, and the didactic goals of his journal; (2) his aesthetic and ideological mediatorship, meaning the structure and composition of his journal as well as the editorial strategies revealing a reader-oriented strategy; and (3) his cultural mediatorship, or his self-defined role as translator and the emphasis he puts on transfer and translation as means of cultural identity construction. By doing so, our case-study provides a first stepping-stone towards a more encompassing study, and thus it enables new insights into the circulation, production, and networks of eighteenth-century literary culture in the Southern Netherlands.
Tracing the European roots of the news about Walter Scott published in the Italian gazettes. A preliminary survey
Authors: Penso Andrea
Published: June 2022

Since the beginning of their capillary diffusion in the Italian peninsula, gazettes contained multitudes of articles about the prominent writers of the time, and were one of the most effective tools for spreading knowledge and information. Nevertheless, the role played by the Italian gazettes in the reception of foreign culture has not been sufficiently investigated. This paper focuses on a particular case study, namely the reception of Walter Scott and his work in the gazzette published in Milan, Turin, Parma, Florence and Naples. The choice of Scott as a case study is not arbitrary: a preliminary reading on the corpus shows that no other foreign author is mentioned as many times as the Scottish novelist. The aim of this article is primarily to show how the Italian gazettes recurrently selected and republished articles about the writer taken from many sources belonging to the British and French press, and explain the attitude the Italian journalists had towards them; secondarily, the study will demonstrate how this crosscultural and polycentric approach favoured the wide spread of information about Scott across the peninsula, which contributed to designing a portrait of the writer even without being in close contact with him or his cultural context.
From Marginalia to Bookends: Industrialization, Capitalism, and Advertising in Hungary’s Modern Literary Journal, Nyugat
Authors: Lo Bello Maya J.
Published: June 2022

[1],this paper examines Nyugat [‘West’], the premier journal ofmodern Hungarian literature published from 1908 to 1941 and edited by ErnőOsvát (1876-1929), Ignotus (1869-1949), and Miksa Fenyő (1877-1972) until 1917.Although Hungarian scholarship has detailed the role played by Osvát andIgnotus, Fenyő’s contribution to this triumvirate has received less attention,a lack that may have hindered literary historians’ understanding of the morewidespread, sociological reasons underlying Nyugat’s long-lastingpresence in a highly competitive book market. Rather than rely exclusively uponthe sources (correspondence, personal journals, memoirs, reports bycontemporaries, etc.) commonly used to investigate the editorial decisionsunderpinning a journal’s trajectory, I argue that examining Fenyő’s editorial positiondemands the inclusion of marginalia, the term this study utilises to denotethe factory advertisements, banking-related notifications, military supplyannouncements, railway schedules, and eulogies that display Fenyő’s ties to theindustrial lobby organisation GyOSz [‘National Association of HungarianIndustrialists’, also referred to as ‘the Association’] within the pages of ajournal dedicated to promoting fin-de-siècle aestheticism. Although the connectionbetween GyOSz and Nyugat has been examined from the perspective ofpublishing strategies or patronage systems, it has not been detailed within thecontext of the era’s expanding market economy. Exploring what Bernard Lahire woulddescribe as Fenyő’s ‘double life’[2] therebypaves the way to theorising what beliefs and ‘rules of the game’ (illusio)may have determined the connection between Hungary’s wealthiest industrialistsand Nyugat during a period when the journal’s editors and authors soughtto attain both authorial and financial autonomy.[1][2] Bernard Lahire, ‘The Double Lifeof Writers’, New Literary History, 41.2 (2010), 443‒465.
From Pure Art to Sheer Luxury: Magazines as Ornamental Constellations and the Emergence of Aesthetic Capitalism in the Early Twentieth Century
Authors: Gretz Daniela , Krause Marcus
Published: June 2022

The concept of ‘ornamental constellations’ introduced in the following article highlights the structural relationships of decorative elements and miscellaneous content in magazines and the importance of the reader’s perspective for their interpretation. ‘Ornamental constellations’ are considered one of the most important media devices of emerging aesthetic capitalism, as they produce economies of attention and affect and establish a visual connection between the basic concept of a magazine, its individual contributions, and the readership addressed, thus promoting a specific aesthetic lifestyle. Their respective staging value is illustrated by analysing two complementary magazines and their constellation techniques: the elitist art magazine Blätter für die Kunst with its ‘strategic arrangement’ of literary and programmatic contributions and the creation of ‘resonances’ between them and the popular sports and society magazine Sport im Bild with its hybridizing flow of texts, images, and advertisements. Despite all the differences, it becomes clear that these are two quite compatible projects within the framework of an emerging aesthetic capitalism: whereas the Blätter für die Kunst staged and materialized the idea of pure art as an exclusive aesthetic lifestyle, the Sport im Bild made the desired aesthetic way of life also attainable by non-artists (with enough money) by associating it with the idea of an aesthetic capitalism.
Status gizi berdasarkan dialysis malnutrition score (DMS) dengan kualitas hidup pasien hemodialisis
Authors: Hayati Dina Maulina , Widiany Fery Lusviana , Nofiartika Fera
Published: June 2022

Nutritional status based on the dialysis malnutrition score (DMS) with hemodialysis patients' quality of lifeBackground: Chronic kidney disease (CKD) is a disorder of the kidney organs characterized by abnormalities in the structure or function of the kidneys. Patients suffering from end-stage CKD require renal replacement therapy in the form of hemodialysis. However, hemodialysis on a routine basis can decrease nutritional status, which will result in malnutrition patients. Malnutrition is associated with morbidity and mortality rates, such as prolonged weakness, susceptibility to infectious diseases, and impaired wound healing that can affect the quality of life. Objective: This study aims to determine the correlation between nutritional status based on the Dialysis Malnutrition Score (DMS) with the quality of life of hemodialysis patients. Methods: The research design was cross-sectional with an observational research design. This research was conducted from 02 September 2019 until 11 September 2019 in the hemodialysis unit at RSUD Panembahan Senopati Bantul with 182 subjects of all chronic kidney disease patients undergoing hemodialysis from 2009 until April 2019. The researcher assessed nutritional status data based on the DMS. In addition, the quality of life was based on Kidney Disease Quality of Life (KDQoL) which researchers for elderly subjects assisted, and some parts filled directly by the subject. The statistical analysis used for this study was the Chi-square test. Results: Based on the Chi-square test, there is a correlation between nutritional status based on the DMS and the quality of life of hemodialysis patients (p-value=0.009). Most subjects had good nutritional status based on the DMS and had good quality on the KDQoL. Conclusions: There is a correlation between the risk of malnutrition based on the Dialysis Malnutrition Score (DMS) and hemodialysis patients' quality of life (KDQoL).
Chemical composition of Bryophyllum pinnatum (Lam.) Oken
Authors: Dogara Abdulrahman Mahmoud
Published: June 2022

Natural chemicals with medicinal qualities are an endless source of chemical molecules, making them a valuable source of pharmacologically active molecules. Humans have always looked for these plants, not only for food but also for medicinal purposes. Bryophyllum pinnatum is a succulent perennial herb native to Africa and Asia. The plants is traditionally used in northern Nigeria for the treatment and management of various ailments. To date, no studies have been carried out on the chemical composition of B. pinnatum in Northern, Nigeria. The study examine the chemical composition of B. pinnatum leaves in Northern, Nigeria. Hydrodistillation was used to extract the essential oil using three different solvents (dichloromethane, hexane and hexane-acetone). The chemical composition of the essential was identified with Gas chromatography coupled with mass spectrometry. Thirty five compounds were identified from the essential oil extracted with dichloromethane, twenty five compounds from the essential oil extracted with hexane and twenty three compounds from essential oil extracted hexane-acetone. But the three solvents were found to be dominant by Bis(2-ethylhexyl) phthalate. The study provides the first chemical composition of B. Pinnatum which can be fully utilised industry and pharmaceutical companies. Further studies is needed to ascertain the pharmacological and industrial usage of each identified compound.
Medication Persistence to Lipid-lowering Agents As A Cost-saving Opportunities on Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention in Indonesia
Authors: Kristin Erna , Krisdinarti Lucia , Yasmina Alfi , Pratiwi Woro Rukmi , Febrinasari Ratih Puspita , Mahati Endang , Indra Jaya Sudi
Published: June 2022

Medication persistence is known to reduce acute coronary syndrome (ACS) disease mortality. As much as 13% of Indonesia's budget on national health insurance programs was used for cardiovascular disease. The number of population-based studies discussing the cost-saving opportunities of medication persistence in ACS patients undergoing percutaneous coronary syndrome (PCI) is still minimal. This study aimed to investigate the estimated cost saving of persistence to lipid-lowering agents in patients with ACS after their first PCI. Hospital-based, retrospective cohort study with 2 years of follow-up was conducted with 367 patients. Patients were deemed as having medication persistence if the gap between prescriptions was ≤ 30 days. Persistence assessment was done for lipid-modifying agents (WHO ATC Code: C10). The main outcome is cost-saving opportunities assessed by dividing the difference in total costs resulting from medication persistence with the difference in the proportion of major adverse cardiovascular events (MACE) and major adverse cardiovascular and cerebrovascular events (MACCE) prevented by medication persistence. The study found that direct medical costs incurred by persistent patients were significantly lower than non-persistent patients with lipid-lowering agents (IDR 9,535,209.76 versus IDR 15,933,959.28). Persistence to lipid-lowering therapy can prevent one MACE incident with cost-saving of IDR 996,192.41 when compared to non-persistence patients, while one MACCE incident can be prevented with cost-saving of IDR 733,103.02. Our study indicates that among ACS patients who underwent their first PCI, medication persistence with lipid-lowering agents can contribute to cost-saving in preventing one MACE or MACCE event. These data will be useful for policymakers to help budget allocation and reemphasize the important role of medication persistence with lipid-lowering therapy in the management of ACS after PCI.
Cyclooxygenase (COX) and 15-Lipoxygenase (15-LOX) Inhibitory Activity and HPTLC Profile of Asplenium Nidus, Diplazium Esculentum, and Drynaria Quercifolia in Bukidnon, Philippines
Authors: Ang Aileen May G. , Sabesaje Roxan D. , Barbosa Gina B. , Cruz Reggie Y. dela , Mendez Rainear A. , Enot Melania M.
Published: June 2022

Diplazium esculentum, Drynaria quercifolia, and Asplenium nidus are among the fern species found in Bukidnon, Philippines which are used as traditional herbal medicines.  The HPTLC profile and the anti-inflammatory properties against cyclooxygenase (COX) and 15-lipoxygenase (15-LOX) of the frond ethanolic extracts of D. esculentum, D. quercifolia, and A. nidus were determined.  The High-Performance Thin Layer Chromatography (HPTLC) profile was obtained using ethyl acetate: formic acid: water (16:2:2) as mobile phase and Natural Products (NP) as derivatizing reagent.  The HPTLC profile of the D. esculentum, D. quercifolia, and A. nidus extracts showed 10 (Rf = 0.02-0.97), 13 (Rf = 0.03-0.90), and 14 (Rf = 0.02-0.99) bands, respectively. The profiles for each fern species may be used as marker for quality evaluation and standardization of herbal formulations containing these plants.  For the anti-inflammatory properties, D. esculentum and D. quercifolia extracts which inhibited more than 50% of the COX enzymes showed significantly higher activity than A. nidus and were considered active against COX-2 and COX-1. D. esculentum, however, gave a selectivity ratio (COX-2/COX-1) of 1.03 making its inhibitory activity selective against COX-2.  The percent 15-LOX inhibitory activity of D. quercifolia (58.62%) is significantly higher than that of A. nidus (38.70%) but statistically comparable to D. esculentum (51.19%).  Among the extracts, D. quercifolia and D. esculentum which inhibited more than 50% of the 15-LOX were considered active. D. esculentum and D. quercifolia can therefore be potential sources of anti-inflammatory lead compounds for future drug development.
VIOLENCE AGAINST PERSONS WITH DISABILITIES: THE “DARK NUMBER” OF CRIME
Authors: Mirić Filip , Nikolajević Aleksandra
Published: June 2022

People with disabilities are a particularly vulnerable to victimization by violence. This risk increases due to their dependence on other family members. This negative phenomenon has to be observed not only from the criminological perspective but also from the sociological perspective because violence does not happen outside the society. In this paper, the authors will indicate the “dark number” of crime of violence against people with disabilities, with specific reference to violence against people with mental disabilities in residential institutions. The aim of this paper is to point out to possible social responses to violence against people with disabilities.
Synthesis, Characterization and Invivo Evaluation of Poly Sulfoxy Amine Grafted Xanthan Gum
Authors: Rahul Laxman Jadhav  , Manisha Vyankatrao  Patil  , Shaikh Siraj N
Published: June 2022

Natural  polymers  are  hydrophilic  in  nature,  economic,  chemically  inert,  easily  available,  biodegradable,  and  non-toxic.  Following problems associated with the use of gums include uncontrolled  rates of hydration, pH dependent solubility, thickening, drop in viscosity on storage, and  the  possibility  of  microbial  contamination.  Chemical  modification  of  gums  not  only  minimizes  these  drawbacks  but  also  alter  their physicochemical  properties.  Recently,  researchers  have  been  modifying  properties  of natural  gums  to explore  its more  applicability.  Aim of the current study was to explore Xanthan gum’s applicability in mucoadhesive  and other property by doing its Chemical modification. Sulfoxy amine modification  of xanthan  gum was carried  out by reacting  xanthan  gum with thionyl  chloride  and further  treated  with ammonia.  FTIR, elemental DSC,  XRD  and SEM  were  studied  for confirmation  of the modification.  The modified  xanthan  gum showed  improvement  in the mucoadhesion, water uptake capacity, gelling property as well as viscosity as compared to unmodified  xanthan gum. The results of X-ray diffraction  study confirms the finding of DSC study. X-ray diffractogram  confirmed XG is typical of amorphous  substance while that of MXG is typical of crystalline substance with the characteristic  peak appearing  at 14.79, 25.66, 29.63 and 31.82 2θ.   The 0.6% w/v of modified  xanthan  gum showed gelling property.  The 0.6% w/v of modified Xanthan Gum showed gelling property where as Xanthan Gum required more than 1% w/v , it indicate that gelling property of Xanthan  Gum has improved  due to its modification.  Mucoadhesive  strength  of modified  xanthan  gum was found to be 4±0.56 gm which is more than xanthan gum i.e. 1.5±0.94 gm. The ionic interactions  may be taken place in between negatively charged mucus with cationic modified polymer and superior mucoadhesion  can be achieved. Rapid and constant swelling behavior was observed by modified Xanthan gum. The SEM image of MXG showed that the grafting of Polysulfoxyamine  onto XG brings about the change in the shape and size of the XG particles.  The enhanced  viscosity and gelling capacity of modified  xanthan  gum were also observed  as compared  to xanthan  gum. In vivo acute toxicity study of Poly sulfoxy amine grafted xanthan gum was performed.  The toxicological  effects were observed in terms of mortality and expressed as LD50.  Results of Acute toxicity study  shows  LD50   value  was  more  than  2 gm/kg  indicating  the low  toxicity.  These  findings  proved  that modified  xanthan  gum  may  be used  as promising excipient in various drug delivery systems.
Anticipation Guides: A Tool to Highlight Knowledge and Promote Reflection on Learning
Authors: Evans D. Reid , Kodela Jennifer , Khan Amna
Published: June 2022

Introduction: Anticipation guides (AGs) are an active learning tool with broad benefit for both learners and instructors. Though AGs have been more extensively studied in the primary and secondary education contexts, their development and implementation, as well as the benefits that they offer to medical education are not as well understood. The objective of this study was to explore the benefits that AGs afford to resident learners and instructors in the resident-led didactic conference setting.
Methods: We performed a qualitative study of the use of anticipation guides in the resident-led didactic conference setting. Participants included 47 resident learners and three chief resident instructors. Data included learner response sheets, instructor reflective journals, and field notes from nonparticipant observation. Data analysis followed guidelines for content analysis.
Results: Results indicate that AGs highlight changes in knowledge and thinking, prompt learners to reflect on their learning, and offer valuable insight into learner achievement and uncertainty to instructors. This input promotes formative assessment of learners and encourages instructors to improve their practice.
Conclusions: Anticipation guides are an easy-to-implement active learning strategy with multiple benefits in the resident didactic conference setting. Their use helps learners recognize strengths and weaknesses and identify gaps in knowledge—behaviors consistent with the goals of residency as espoused by the Accreditation Council for Graduate Medical Education. Including AGs in instruction also benefits instructors in that they provide insight into learners' thinking and knowledge development and allow educators to assess the efficacy of their instruction.
Customer governance and segmentation using database algorithm
Authors: Biberaj Aleksandër , Shurdi Olimpjon , Balliu Lorena , Xhaferllari Sonila , Imami Julian
Published: June 2022

The primary goal of any business is to maximize its profits. The company must have the right customers to ensure its continuous existence. This paper aims to help a company identify the right customers by developing a flow that enables them to easily do so. Customers for sure progress from one loyalty stage to the next in time, and marketing actions can help them to do so (Ngobo, 2017). The focus is on the problem of identifying the right customers based on what the company needs at that moment (the best-performing ones, the new ones, the ones who will retain, etc.). The methodology will include an analysis of data previously stored by the company. It will give technical details of how this flow is created and how is practically implemented. The existing data, is manipulated more appropriately and then passed and stored in a dedicated PostgreSQL database. This kind of database offers important techniques such as advanced indexing and high availability to build scalable, reliable, and fault-tolerant database applications (Schönig, 2020). In conclusion, the paper will give the effects of the actions taken based on the lists generated by the created logic.
Successful Ablation of a Wide Complex Tachycardia with Distinct Intra-Cardiac Electrograms
Authors: konstantino yuval , Buturlin Kirill , Westreich Roi , Bereza Sergiy , Levitas Aviva , Slanovic Leonel , Haim Moti
Published: June 2022

A 13-year-old boy was hospitalized after a syncopal episode that
occurred during exercise. He suddenly felt chest tightness, sweating and
palpitations, followed by a transient loss of conciseness. Upon
emergency medical team arrival, he was awake and oriented. Baseline ECG
showed sinus rhythm at a rate of 98 bpm, with narrow QRS, and no signs
of long QT, Brugada, or pre-excitation. Physical examination, blood
tests, 24 hours Holter monitoring, transthoracic echocardiography and
stress test were all within normal limits. Eight days later he
experienced a second episode of palpitations while walking to school.
ECG revealed regular wide complex tachycardia (WCT) at a rate of 200
bpm, with LBBB morphology that terminated with Adenosine (Figure 1). The
clinical tachycardia was easily induced by programmed electrical
stimulation (Figure 2A). Diagnostic electrophysiological maneuver
(Figure 2B) was followed by successful ablation, during which a unique
phenomenon was noted (Figure 3). What is the diagnosis of the
tachycardia and what are the unique findings noted during and after
ablation?
I livsens lundar. Debutromanen til Matias Orheim
Authors: Sørbø Jan Inge
Published: June 2022

This article presents the first novel by the Norwegian songwriter and preacher Matias Orheim (1884–1958). Orheim was an important figure in the laymen movement during his lifetime. He was also a famous singer and musician (playing violin and glass harmonica). A lesser-known fact is that he wrote a number of novels during the period 1911 to 1938. While his books of religious songs and hymns were very successful, with sales numbers up to 65,000 for one book, his novels were less popular. The article argues that the novel I livsens lundar (In Life’s Groves) provides an accurate depiction of the different cultural and religious groups in rural Norway in the early 20th century. There was a tension between the Grundtvig-inspired national movement and the low church evangelical movement. The former was very concerned with national language and tradition (folklore, folk dance), while the latter was more explicitly concerned with religious conversion and personal piety. Orheim tried to make a kind of compromise – a low church religion open to national and cultural impulses – and his novel is an example of this; it is written in the form the Grundtvig groups used in their meetings, with a lot of verse, small dramas and use of Norse mythology.
Ordmusikken. Ivar Mortensson-Egnund som bibelomsetjar
Authors: Aschim Anders
Published: June 2022

As a journalist, poet, playwright and Bible translator, the Norwegian theologian Ivar Mortensson-Egnund (1857–1934) was an important figure in the Norwegian nynorsk language movement. Mortensson translated about a third of the Old Testament from Hebrew into nynorsk, but most of this work remained unpublished and is probably lost. The article documents the extent of his Bible translations and discusses his translation practice. Mortensson is seen as a proponent of a romantic hermeneutics in the tradition of Schleiermacher. Translations of Bible passages are also important elements in his literary works, both in an early “anarchist” period and in a later “mystical” period.
Pengembangan Model Pembelajran PJOK Tematik Terintegratif Tema Diriku (Subtema 3: Aku Merawat Tubuhku) Untuk Peserta Didik Kelas 1 SD Di Kecamatan Buleleng
Authors: Mahaditya Ida Bagus Gede Indra , Parwata I Gusti Lanang Agung , Dartini Ni Putu Dwi Sucita
Published: June 2022

This study aims, 1) to develop an integrated thematic-based PJOK learning module with the theme myself sub-theme 3: I take care of my body for 1st-grade elementary school students in Buleleng District. 2) knowing the results of the expert validity test on the integrated thematic PJOK game module, sub-theme 3: I take care of my body for 1st-grade elementary school students in Buleleng District. This type of research is research on the development of R&D methods using the Borg and Gall design. The data collection instrument used was a questionnaire. The data analysis technique used is descriptive quantitative and qualitative. The results of the study show that 1) the design of the learning module uses three stages, namely: research and information gathering, planning, and developing a preliminary form of the product. These three stages resulted in an integrated thematic PJOK game module, sub-theme 3: I take care of my body for 1st-grade elementary school students. 2) validation of teaching materials in terms of content aspects with a total percentage of 91.76% being in the very good category. The media aspect with a percentage of 90% is in the very good category. The aspect of field practitioners with a percentage of 85% is in a good category. Based on the results of the study, it can be concluded that the development of an integrated thematic PJOK learning module with the theme of myself sub-theme 3: I take care of my body for 1st-grade elementary school students in Buleleng District is feasible to use.
Persepsi Wisatawan Tentang Wahana Olahraga Underwater di desa Bangsring Kabupaten Banyuwangi
Authors: Hanafi Rahma , Wahjoedi Wahjoedi , Semarayasa I ketut
Published: June 2022

AbstrakPenelitan ini bertujuan untuk mengetahui persepsi wisatawan tentang wahana olahraga underwater di Desa Bangsring Kabupaten Banyuwangi. Jenis penelitain ini adalah jenis penelitian deskriptif kuantitatif, dengan menggunakan metode survey dengan teknik pengambilan data observasi, kuisioner dan dokumentasi. Populasi dalam penelitian ini adalah wisatawan yang berkunjung di wisata bangsring underwater dimana mereka yang telah menikmati wahana olahraga underwater. Analisis data yang digunakan dalam penelitian ini yaitu deskriptif kualitatif dengan persentase. Hasil dari penelitian ini menunjukkan bahwa (1) sumber informasi dan tujuan  berkunjung memiliki persentase baik dengan 85%. (2) sarana dan prasarana pariwisata olahraga underwater memiliki persentase yang baik dengan 89%. (3) keunikan wahana olahraga underwater di desa bangsring memiliki persentase sangat baik yaitu 91,4%. (4)Jenis layanan wisata memiliki persentase cukup baik dengan 84%. (5) pengelolaan tempat wisata memiliki persentase cukup baik juga dengan 87,5%. Berdasarkan hasil dari analisis data dalam penelitian ini, maka dapat disimpulkan bahwa persepsi wisatawan tentang wahana olahraga underwater khususnya snorkeling dan diving di Desa Bangsring Kabupaten Banyuwangi dengan keseluruhan dapat dikatakan baik. Penelitian ini diharapkan menjadi acuan pengelola wisata bangsring underwater agar meningkatkan kualitas pengelolaan, pelayanan dan penambahan wahana baru agar menambah daya tarik wisatawan untuk berkunjung.
Motivasi Siswa Mengikuti Ekstrakurikuler Bola Voli di SMPN se-Kecamatan Selemadeg Timur Kabupaten Tabanan
Authors: Prihanto Arimbawa Komang Agus , Sudiana I Ketut , Sudarmada I Nyoman
Published: June 2022

Tujuan penelitian ini adalah untuk mengetahui seberapa tinggi motivasi intrinsik dan ekstrinsik yang melandasi keikutsertaan siswa dalam kegiatan ekstrakurikuler bola voli di SMPN se-Kecamatan Selemadeg Timur Kabupaten Tabanan. Instrumen yang digunakan berupa angket/kuesioner dan analisis deskriptif kualitatif dengan persentase. Populasi penelitian ini adalah seleuruh siswa yang mengikuti kegiatan ekstrakurikuler bola voli di SMPN se-Kecamatan Selemadeg Timur Kabupaten Tabanan. Sampel yang diambil sebanyak 90 siswa. Variabel yang diteliti adalah motivasi mengikuti ekstrakurikuler bola voli yang terbagi atas motivasi intrinsik dan motivasi ekstrinsik. Berdasarkan hasil penelitian dapat diambil kesimpulan bahwa motivasi siswa mengikuti ekstrakurikuler bola voli di SMPN se-Kecamatan Selemadeg Timur Kabupaten Tabanan dapat dikategorikan tinggi, dimana 89 atau 98,8% orang responden dapat dikategorikan memiliki motivasi tinggi sedangkan 1 atau 1,1% orang responden dapat dikategorikan cukup tinggi. Secara spesifik motivasi siswa dapat dikategorikan menjadi motivasi intrinsik dan ekstrinsik. Motivasi intrinsik siswa dikategorikan tinggi dimana 90 atau 100% orang responden berada dalam kategori tinggi. Pada motivasi ekstrinsik 87 atau 96,6% orang responden dikategorikan memiliki motivasi ekstrinsik yang tinggi sedangkan 3 atau 3,3% orang responden dikategorikan cukup tinggi. Saran bagi para guru terutama guru pendidikan jasmani dan kesehatan dapat mempertahankan motivasi siswa dalam mengikuti ekstrakurikuler bola voli. Pihak sekolah dan guru pembina dapat mempertahankan bahkan meningkatkan aspek-aspek eksternal yang mempengaruhi motivasi yakni saran dan prasarana penunjang ekstrakurikuler bola voli.
Pelaksanaan Pembelajaran Pendidikan Jasmani Olahraga Dan Kesehatan Pada Masa Pandemi Covid-19 Tingkat SMA Negeri Se-Kabupaten Gianyar Bali
Authors: Nadi Ni Kadek Merta
Published: June 2022

Penelitian ini bertujuan untuk mengetahui pelaksanaan pembelajaran pendidikan jasmani olahraga dan kesehatan pada masa pandemi Covid-19 tingkat SMA Negeri se-Kabupaten Gianyar Bali. Populasi dalam penelitian ini adalah semua guru mata pelajaran PJOK di SMA Negeri se-Kabupaten Gianyar yang berjumlah 26 orang. Sampel dalam penelitian ini adalah 26 orang guru PJOK. Teknik analisis data pada riset ini adalah penelitian deskriptif. Sedangkan untuk menganalisa kuesioner digunakan Skala Likert untuk menghitung data kuesioner yang diisi oleh responden. Hasil riset menunjukkan bahwa Pelaksanaan pembelajaran PJOK pada masa pandemi COVID-19 se-Kabupaten Gianyar telah berjalan dengan baik dengan nilai rata-rata sebesar 4,20 dengan kategori baik. Tanggapan guru PJOK dalam pembelajaran PJOK pada masa pandemi Covid-19 menyatakan bahwa peserta didik dapat dengan baik mengikuti pembelajaran daring dengan bantuan media yang telah disepakati bersama-sama.