bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Proteogenomics to Urine Analysis towards the Identification of Novel Biomarkers of Prostate Cancer: An Exploratory Study
Authors: Lima Tânia , Barros António S. , Trindade Fábio , Ferreira Rita , Leite-Moreira Adelino , Barros-Silva Daniela , Jerónimo Carmen , Araújo Luís , Henrique Rui , Vitorino Rui , Fardilha Margarida
Published: April 2022

To identify new protein targets for PCa detection, first, a shotgun discovery experiment was performed to characterize the urinary proteome of PCa patients. This revealed 18 differentially abundant urinary proteins in PCa patients. Second, selected targets were clinically tested by immunoblot, and the soluble E-cadherin fragment was detected for the first time in the urine of PCa patients. Third, the proteogenome landscape of these PCa patients was characterized, revealing 1665 mutant protein isoforms. Statistical analysis revealed 6 differentially abundant mutant protein isoforms in PCa patients. Analysis of the likely effects of mutations on protein function and PPIs involving the dysregulated mutant protein isoforms suggests a protective role of mutations HSPG2*Q1062H and VASN*R161Q and an adverse role of AMBP*A286G and CD55*S162L in PCa patients. This work originally characterized the urinary proteome, focusing on the proteogenome profile of PCa patients, which is usually overlooked in the analysis of PCa and body fluids. Combined analysis of mass spectrometry data using two different software packages was performed for the first time in the context of PCa, which increased the robustness of the data analysis. The application of proteogenomics to urine proteomic analysis can be very enriching in mutation-related diseases such as cancer.
The Simpson Grading: Is It Still Valid?
Authors: Chotai Silky , Schwartz Theodore H.
Published: April 2022

The Simpson Grade was introduced in the era of limited resources, outdated techniques, and rudimentary surgical and imaging technologies. With the advent of modern techniques including pre- and post-operative imaging, microsurgical and endoscopic techniques, advanced histopathology and molecular analysis and adjuvant radiotherapy, the utility of the Simpson Grade scale for prognostication of recurrence after meningioma resection has become less useful. While the extent of resection remains an important factor in reducing recurrence, a subjective naked-eye criteria to Grade extent of resection cannot be generalized to all meningiomas regardless of their location or biology. Achieving the highest Simpson Grade resection should not always be the goal of surgery. It is prudent to take advantage of all the tools in the neurosurgeons’ armamentarium to aim for maximal safe resection of meningiomas. The primary goal of this study was to review the literature highlighting the Simpson Grade and its association with recurrence in modern meningioma practice. A PubMed search was conducted using terms “Simpson”, “Grade”, “meningioma”, “recurrence”, “gross total resection”, “extent of resection” “human”. A separate search using the terms “intraoperative imaging”, “intraoperative MRI” and “meningioma” were conducted. All studies reporting prognostic value of Simpson Grades were retrospective in nature. Simpson Grade I, II and III can be defined as gross total resection and were associated with lower recurrence compared to Simpson Grade IV or subtotal resection. The volume of residual tumor, a factor not considered in the Simpson Grade, is also a useful predictor of recurrence. Subtotal resection followed by stereotactic radiosurgery has similar recurrence-free survival as gross total resection. In current modern meningioma surgery, the Simpson Grade is no longer relevant and should be replaced with a grading scale that relies on post-operative MRI imaging that assess GTR versus STR and then divides STR into > or <4–5 cm3, in combination with modern molecular-based techniques for recurrence risk stratification.
Determinants of Survival and Post-Progression Outcomes by Sorafenib–Regorafenib Sequencing for Unresectable Hepatocellular Carcinoma
Authors: Lee I-Cheng , Chao Yee , Lee Pei-Chang , Chen San-Chi , Chi Chen-Ta , Wu Chi-Jung , Wu Kuo-Cheng , Hou Ming-Chih , Huang Yi-Hsiang
Published: April 2022

The predictors of response and survival in patients with hepatocellular carcinoma (HCC) receiving regorafenib remain unclear. This study aimed to delineate the determinants of response and survival after regorafenib and evaluate post-progression treatment and outcomes. We retrospectively enrolled 108 patients with unresectable HCC receiving regorafenib after sorafenib failure. Progression-free survival (PFS), overall survival (OS), post-progression survival (PPS) and post-progression treatments were evaluated. The median PFS, OS and PPS were 3.1, 13.1 and 10.3 months, respectively. Achieving disease control by prior sorafenib, early AFP reduction and hand-foot skin reaction (HFSR) were associated with significantly better radiologic responses. By multivariate analysis, the time to progression on prior sorafenib, HFSR and early AFP reduction were associated with PFS; ALBI grade, portal vein invasion, HFSR and early AFP reduction were associated with OS. ALBI grade at disease progression, main portal vein invasion, high tumor burden and next-line therapy were associated with PPS. The median PPS was 12 months in patients who received next-line therapy, and the PPS was comparable between patients who received next-line targeted agents and immunotherapy. In conclusion, survival outcomes of regorafenib for HCC have improved in the era of multi-line sequential therapy. Preserved liver function and next-line therapy are important prognostic factors after regorafenib failure.
The Preparation of g-C3N4/CoAl-LDH Nanocomposites and Their Depollution Performances in Cement Mortars under UV-Visible Light
Authors: Huang Mengya , Yang Zhengxian , Lu Lin , Xu Jiankun , Wang Wencheng , Yang Can
Published: April 2022

In this study, new organic-inorganic g-C3N4/CoAl-LDH nanocomposites were prepared and introduced to fabricate photocatalytic cement mortars by internal mixing, coating, and spraying. The photocatalytic depollution of both g-C3N4/CoAl-LDH and cement mortars was assessed by NOx degradation reaction under UV-visible light irradiation. The study results suggested that the degradation efficiency of g-C3N4/CoAl-LDH nanocomposites improved with an increase in g-C3N4 content. The g-C3N4/CoAl-LDH1.5 nanocomposite displayed the highest NOx degradation capacity, which was about 1.23 and 3.21 times that of pure g-C3N4 and CoAl-LDH, respectively. The photocatalytic cement mortars which were all fabricated using different approaches could effectively degrade the target pollutants and exhibited significant compatibility between g-C3N4/CoAl-LDH and cementitious substrate. Among them, the coated mortars showed strong resistance to laboratory-simulated wearing and abrasion with a small decrease in degradation rate.
Rank-Rankl-Opg Axis in Multiple Sclerosis: The Contribution of Placenta
Authors: Passaponti Sofia , Ermini Leonardo , Acconci Giulia , Severi Filiberto Maria , Romagnoli Roberta , Cutrupi Santina , Clerico Marinella , Guerrera Gisella , Ietta Francesca
Published: April 2022

Women with multiple sclerosis (MS) can safely become pregnant and give birth, with no side effects or impediments. Pregnancy is generally accepted as a period of well-being in which relapses have a softer evolution, particularly in the third trimester. Herein, we hypothesized that the placenta, via its “secretome”, could contribute to the recognized beneficial effects of pregnancy on MS activity. We focused on a well-known receptor/ligand/decoy receptor system, such as the one composed by the receptor activator of nuclear factor-kB (RANK), its ligand (RANKL), and the decoy receptor osteoprotegerin (OPG), which have never been investigated in an integrated way in MS, pregnancy, and placenta. We reported that pregnancy at the term of gestation influences the balance between circulating RANKL and its endogenous inhibitor OPG in MS women. We demonstrated that the placenta at term is an invaluable source of homodimeric OPG. By functional studies on astrocytes, we showed that placental OPG suppresses the mRNA expression of the CCL20, a chemokine responsible for Th17 cell recruitment. We propose placental OPG as a crucial molecule for the recognized beneficial effect of late pregnancy on MS and its potential utility for the development of new and more effective therapeutic approaches.
Raman Activities of Cyano-Ester Quinoidal Oligothiophenes Reveal Their Diradical Character and the Proximity of the Low-Lying Double Exciton State
Authors: Dai Yasi , Bonometti Laura , Zafra José Luis , Takimiya Kazuo , Casado Juan , Negri Fabrizia
Published: April 2022

Quinoidal oligothiophenes have received considerable attention as interesting platforms with remarkable amphoteric redox behavior associated with their diradical character increasing with the conjugation lengths. In this work, we considered a family of quinoidal oligothiophenes bearing cyano-ester terminal groups and characterized them by UV-Vis-NIR absorption and Raman spectroscopy measurements at different excitation wavelengths. The experimental investigation is complemented by quantum-chemical studies to assess the quality of computed density functional theory (DFT) ground state structures and their influence on predicted Raman intensities. In addition, resonance conditions with the optically active HOMO→LUMO transition as well as with the more elusive state dominated by the doubly excited HOMO,HOMO→LUMO,LUMO configuration, are determined with DFT-MRCI calculations and their contributions to Raman activity enhancement are discussed in terms of computed vibrational Huang–Rhys (HR) factors.
UV-Activated NO2 Gas Sensing by Nanocrystalline ZnO: Mechanistic Insights from Mass Spectrometry Investigations
Authors: Chizhov Artem , Kutukov Pavel , Gulin Alexander , Astafiev Artyom , Rumyantseva Marina
Published: April 2022

In this work, the photostimulated processes of O2 and NO2 molecules with the surface of ZnO under UV radiation were studied by in situ mass spectrometry in the temperature range of 30–100 ∘C. Nanocrystalline needle-like ZnO was synthesized by decomposition of basic zinc carbonate at 300 ∘C, and the surface concentration of oxygen vacancies in it were controlled by reductive post-annealing in an inert gas at 170 ∘C. The synthesized materials were characterized by XRD, SEM, low-temperature nitrogen adsorption (BET), XPS, Raman spectroscopy, and PL spectroscopy. Irradiation of samples with UV light causes the photoabsorption of both O2 and NO2. The photoadsorption properties of ZnO are compared with its defective structure and gas-sensitive properties to NO2. A model of the sensor response of ZnO to NO2 under UV photoactivation is proposed.
Educating Parents Improves Their Ability to Recognize Adolescent Idiopathic Scoliosis: A Diagnostic Accuracy Study
Authors: de Groot Charlotte , Heemskerk Johan L. , Willigenburg Nienke W. , Altena Mark C. , Kempen Diederik H. R.
Published: April 2022

(1) In countries where scoliosis screening programs ended, the responsibility for detection shifted from healthcare professionals to parents. Since recognizing scoliosis is difficult for parents, more patients are presenting late. Increased awareness of scoliosis may favor earlier detection. This study examines the effect of educating parents to recognize scoliosis. (2) In this cross-sectional study a consecutive group of parents completed a digital assessment. They had to complete two identical series of fourteen cases (eight with scoliosis and six without). Each case displayed two photographs of the child’s back; one in standing position and one during forward-bending. Based on visual inspection, parents had to indicate if the child had to be referred to a physician. After assessing the first series, information was given on how to detect scoliosis. Subsequently, parents assessed the second series of cases. Sensitivity and specificity were calculated before and after education. (3) A total of 100 parents completed the assessment. The sensitivity to detect scoliosis was slightly but significantly higher after education (68.8% versus 74.0%; p = 0.002), while specificity was not (74.0% versus 74.8%; p = 0.457). (4) This study showed that educating parents improved their ability to recognize scoliosis without increasing the false positive referral rate. Although written instructions can bridge the gap with professional screening programs, the overall sensitivity in this study remained low. Therefore, education can improve the awareness and ability to detect scoliosis, but will not replace screening by professionals.
Infection-Triggered Hyperinflammatory Syndromes in Children
Authors: Rossano Martina , Rogani Greta , D’Errico Maria Maddalena , Cucchetti Martina , Baldo Francesco , Torreggiani Sofia , Beretta Gisella , Lanni Stefano , Petaccia Antonella , Agostoni Carlo , Filocamo Giovanni , Minoia Francesca
Published: April 2022

An association between infectious diseases and macrophage activation syndrome (MAS) has been reported, yet the exact role of infection in MAS development is still unclear. Here, a retrospective analysis of the clinical records of patients with rheumatic diseases complicated with MAS who were treated in a pediatric tertiary care center between 2011 and 2020 was performed. Any infection documented within the 30 days preceding the onset of MAS was reported. Out of 125 children in follow-up for systemic rheumatic diseases, 12 developed MAS, with a total of 14 episodes. One patient experienced three episodes of MAS. Clinical and/or laboratory evidence of infection preceded the onset of MAS in 12 events. Clinical features, therapeutic strategies, and patient outcomes were described. The aim of this study was to evaluate the possible role of infection as a relevant trigger for MAS development in children with rheumatic conditions. The pathogenetic pathways involved in the cross-talk between uncontrolled inflammatory activity and the immune response to infection deserve further investigation.
‘Teratoid’ Hepatoblastoma: An Intriguing Variant of Mixed Epithelial-Mesenchymal Hepatoblastoma
Authors: Sergi Consolato M. , Rojas-Vasquez Marta , Noga Michelle , Dicken Bryan
Published: April 2022

Liver neoplasms are quite rare in childhood. They often involve 6.7 cases per 10 million children aged 18 years or younger. Hepatoblastoma (HB) is the most frequent tumor, but this neoplasm’s rarity points essentially to the difficulty of performing biologic studies and large-scale therapeutic trials. On the pathological ground, HB is separated into an entirely epithelial neoplasm or a mixed neoplasm with epithelial and mesenchymal components. This last category has been further subdivided into harboring teratoid features or not. The ‘teratoid’ HB includes a mixture of components with heterologous origin. The heterologous components include neuroectoderm, endoderm, or melanin-holding cells with or without mesenchymal components. The most important criterium for the teratoid component is neuroepithelium, melanin, and, more recently, a yolk-sac-like component and neuroendocrine components. The mesenchymal components include muscle, osteoid, and cartilage, which are most often observed mainly in ‘teratoid’ neoplasms. The teratoid component or mesenchymal components are diagnosed with biopsies. They appear more prominent after chemotherapy due to the response and shrinkage of epithelial elements and non- or low-responsive components of mixed HB. This review focuses on the clinical, radiological, and pathological findings of HB with teratoid features.
Validity of the Demirjian Method for Dental Age Estimation in Romanian Children
Authors: Moca Abel Emanuel , Ciavoi Gabriela , Todor Bianca Ioana , Negruțiu Bianca Maria , Cuc Emilia Albinița , Dima Raluca , Moca Rahela Tabita , Vaida Luminița Ligia
Published: April 2022

Dental age assessment is useful in various medical fields. The Demirjian method for dental age estimation is one of the most widely used in the field of pediatric dentistry. The aim of this study was to verify the accuracy of the Demirjian method in determining age in a sample of girls and boys from Oradea, Romania. This retrospective and radiographic study was based on the evaluation of 1006 panoramic radiographs, belonging to 1006 patients (431 boys and 575 girls) with ages between 3 and 13.9 years from the city of Oradea, Romania. They were collected from three private dental practices from Oradea and were analyzed between 1 September 2021, and 10 November 2021. The patients were distributed into 11 age groups, each group spanning over one year (e.g., 3–3.9, 4–4.9). For the assessment of dental age, the Demirjian method was used, which is based on the evaluation of the developmental stages of the lower left permanent teeth. The mean chronological age of the patients was 9.496 ± 2.218 years, and the mean dental age was 10.934 ± 2.585 years. The overestimation of dental age was obtained in all age groups for the entire sample. As such, dental age was higher than chronological age, with values varying from 0.34 years in the 3–3.9 years age group to 1.7 years in the 10–10.9 years age group. In girls, dental age was higher than chronological age, with values varying from 0.46 years in the 3–3.9 years age group to 1.73 years in the 11–11.9 years age group, while in boys, the values varied from 0.15 years in the first age group to 2.02 years in the 10–10.9 years age group. The comparison of the differences between chronological age and dental age according to the gender of the patients revealed that the distribution of the differences was nonparametric in both groups according to the Shapiro–Wilk test (p < 0.05). The differences between the groups were not significant according to the Mann–Whitney U test. However, larger differences were identified for boys (1.46 years) than girls (1.417 years), with an overestimation of the dental age. The Demirjian method overestimated the age of the children included in the investigated sample, with different values for the different age groups investigated, and requires adaptations.
Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients
Authors: Stoll Matthew , DeQuattro Kimberly , Li Zhixiu , Sawhney Henna , Weiss Pamela , Nigrovic Peter , Wright Tracey , Schikler Kenneth , Edelheit Barbara , Morrow Casey , Reveille John , Brown Matthew , Gensler Lianne
Published: April 2022

Multiple studies have shown the microbiota to be abnormal in patients with spondyloarthritis (SpA). The purpose of this study was to explore the genetic contributions of these microbiota abnormalities. We analyzed the impact of HLA-B27 on the microbiota of children at risk for SpA and compared the microbiota of HLA-B27+ pediatric offspring of ankylosing spondylitis (AS) patients with that of HLA-B27+ children with SpA. Human DNA was obtained from the offspring for determination of HLA-B27 status and polygenic risk score (PRS). Fecal specimens were collected from both groups for sequencing of the V4 region of the 16S ribosomal RNA gene. Among the offspring of AS patients, there was slight clustering by HLA-B27 status. After adjusting for multiple comparisons, five operational taxonomic units (OTUs) representing three unique taxa distinguished the HLA-B27+ from negative children: Blautia and Coprococcus were lower in the HLA-B27+ offspring, while Faecalibacterium prausnitzii was higher. HLA-B27+ offspring without arthritis were compared to children with treatment-naïve HLA-B27+ SpA. After adjustments, clustering by diagnosis was present. A total of 21 OTUs were significantly associated with diagnosis state, including Bacteroides (higher in SpA patients) and F. prausnitzii (higher in controls). Thus, our data confirmed associations with B. fragilis and F. prausnitzii with juvenile SpA, and also suggest that the mechanism by which HLA-B27 is associated with SpA may not involve alterations of the microbiota.
Longitudinal Motor-Developmental Outcomes in Infants with a Critical Congenital Heart Defect
Authors: Sprong Maaike C. A. , van Brussel Marco , de Vries Linda S. , van der Net Janjaap , Nijman Joppe , Breur Johannes M. P. J. , Slieker Martijn G.
Published: April 2022

Infants with critical congenital heart defects (CCHDs) are at increased risk for neurodevelopmental delays. The early identification of motor delays is clinically relevant to prevent or reduce long-term consequences. The current study aims to describe the motor-developmental pathways of infants with a CCHD. Motor development was assessed in 215 infants and toddlers using the Dutch version of the Bayley-III. At 3 months (n = 165), 9 months (n = 188), and 18 months (n = 171) the motor composite scores were 97, 98, and 104, respectively. A motor composite score of ≤−2 SD was only seen in 2.4%, 0%, and 2.3%, respectively, with gross motor deficits being observed more often than fine motor deficits (12% vs. 0% at 18 months). Over 90% of infants who scored average at 9 months still did so at 18 months. The majority of infants with below-average gross motor scores (≤−1) at 9 months still had a below-average or delayed motor score (≤−2 SD) at 18 months. Abnormal gross motor scores (≤−2 SD) increased with age. Infants with single-ventricle physiology performed significantly (p ≤ 0.05) worse on both fine and gross motor skills at 9 and 18 months compared to infants with other CCHDs.
Gloss Level of HDF Finished with Different Numbers of Layers and Hardened with UV Hg-Ga Lamps of Selected Power
Authors: Henke Milena , Lis Barbara , Krystofiak Tomasz
Published: April 2022

A key feature of varnish coatings on furniture surfaces is their optical properties, which often determine customers’ purchase choices. Furniture may be produced using various boards, which are much cheaper than wood-based materials. For their finishing, among others, UV-cured varnish products are used. The aim of this study was to determine the effect of different types of HDF boards, the amount of basecoat and topcoat applied, the number of layers, and the different lamp powers used for hardening on the gloss of coatings obtained using UV technology. The gloss was tested with a photoelectric apparatus. An auxiliary parameter in the assessment of the gloss of the coatings was the surface roughness, which was measured with the Mitutoyo SJ-210 Analysis of variance (ANOVA) was used to obtain the results. Statistical considerations showed that the amount of topcoat applied, the power of the lamps, and the interactions between them had the greatest impact on gloss, followed by the number of layers. In general, the gloss of the coating decreased with a decrease in lamp power in the range of 120–60 W/cm and with an increase in the amount of topcoat applied.
Validation of the BC-Brain Patient-Reported Outcome Questionnaire for Patients with Central Nervous System Tumours Treated with Radiotherapy
Authors: Yan Ling , Nichol Alan , Olson Robert
Published: April 2022

The BC-brain questionnaire was developed by BC Cancer to detect health problems in patients with central nervous system (CNS) tumours in routine clinical care, treated with radiotherapy (RT), as part of the Prospective Outcomes and Support Initiative (POSI). This study aimed to present and validate the BC-brain questionnaire in patients with brain metastases (BrM) treated with RT. The BC-brain questionnaire was constructed with three subscales: mobility, thinking and CNS symptoms. Patients with BrM from five BC Cancer centres completed this questionnaire at first visit and subsequent follow-up appointments. A total of 365 patients finished the first and 105 finished the follow-up questionnaire. Summary scores of each subscale were calculated. Mobility, thinking and subtotal score showed good reliability with Cronbach’s α > 0.7. Multitrait scaling analysis showed good convergent and divergent validity. The correlations between subscales ranged from 0.262 to 0.456 for baseline and from 0.378 to 0.597 for follow-up. Patients on dexamethasone had worse performance. Patients with a KPS of </=70 had worse performance than patients with a KPS of >70. In general, this BC-brain questionnaire has good reliability and validity, and is proper to use as an option for a patient-reported outcome (PRO) instrument to measure the quality of life in BrM patients treated with RT.
Taxonomic Discussion on Cyanobacterial Systematics at Family Level, with Special Regards to Phormidiaceae by Using the Strains of Chinese Newly Recorded Genera Ancylothrix and Potamolinea
Authors: Cheng Yao , Geng Ruozhen , Shan Liang , Liu Yang , Zhang He , Xiao Peng , Ma Zengling , Li Renhui
Published: April 2022

In the past decades, the taxonomic status of the cyanobacterial family Phormidiaceae has always been chaotic and problematic. In this study, filamentous cyanobacteria were investigated in the east of China, and twenty strains isolated from different locations of Zhejiang Province were characterized. Using the polyphasic approach combining morphological, molecular and phylogenetic features, these strains were grouped within the members of the genera Ancylothrix and Potamolinea, the newly recorded genera of cyanobacteria in China. Based on the collected taxonomic information of the family Phormidiaceae, cyanobacterial systematics at family level were further discussed. This study provided a simple and efficient example to perform the phylogenetic evaluation for the monophyly and rationality of currently used families of cyanobacteria by using the regional strains based on the polyphasic approach.
The Tyndall Effect in High-Resolution Computed Tomography of Semicircular Canalolithiasis with Benign Paroxysmal Positional Vertigo
Authors: Chen Jiann-Jy , Lui Chun-Chung , Chen Tien-Yu , Tseng Ping-Tao , Hung Chao-Ming
Published: April 2022

To date, along with the progress of new technology and computer program development, the high-resolution computed tomography (HRCT) had been applied in different clinical application, such as HRCT for coronary angiography. In the current neuroimaging reports, we present HRCT images of the head/neck of two cases, in which one had a diagnosis of benign paroxysmal positional vertigo (BPPV) and the other did not, to represent the Tyndall effect, which describes the scattering of light by particles (i.e., semicircular canalolithiasis) in the path of light and enables clinicians to see a specific signal on the HRCT images. On the HRCT image of the patient with canalolithiasis with BPPV, we could obviously see the scattering effect (i.e., Tyndall effect) in the horizontal/posterior semicircular canal; however, on the HRCT image of the other without canalolithiasis, we could not see such findings. Therefore, through the assistance of technological progress, HRCT might be beneficial in the diagnosis of semicircular canalolithiasis, which has the advantage of being noninvasive and having a low risk of complications. However, because of the disadvantages of expense and risk of radiation exposure, HRCT should be reserved for patients who are difficult to diagnose.
Radiomics for the Prediction of Response to Antifibrotic Treatment in Patients with Idiopathic Pulmonary Fibrosis: A Pilot Study
Authors: Yang Cheng-Chun , Chen Chin-Yu , Kuo Yu-Ting , Ko Ching-Chung , Wu Wen-Jui , Liang Chia-Hao , Yun Chun-Ho , Huang Wei-Ming
Published: April 2022

Antifibrotic therapy has changed the treatment paradigm for idiopathic pulmonary fibrosis (IPF); however, a subset of patients still experienced rapid disease progression despite treatment. This study aimed to determine whether CT-based radiomic features can predict therapeutic response to antifibrotic agents. In this retrospective study, 35 patients with IPF on antifibrotic treatment enrolled from two centers were divided into training (n = 26) and external validation (n = 9) sets. Clinical and pulmonary function data were collected. The patients were categorized into stable disease (SD) and progressive disease (PD) groups based on functional or radiologic criteria. From pretreatment non-enhanced high-resolution CT (HRCT) images, twenty-six radiomic features were extracted through whole-lung texture analysis, and six parenchymal patterns were quantified using dedicated imaging platforms. The predictive factors for PD were determined via univariate and multivariate logistic regression analyses. In the training set (SD/PD: 12/14), univariate analysis identified eight radiomic features and ground-glass opacity percentage (GGO%) as potential predicators of PD. However, multivariate analysis found that the single independent predictor was the sum entropy (accuracy, 80.77%; AUC, 0.75). The combined sum entropy-GGO% model improved the predictive performance in the training set (accuracy, 88.46%; AUC, 0.77). The overall accuracy of the combined model in the validation set (SD/PD: 7/2) was 66.67%. Our preliminary results demonstrated that radiomic features based on pretreatment HRCT could predict the response of patients with IPF to antifibrotic treatment.
Surgical Treatment in Silicone Oil-Associated Glaucoma
Authors: Cornacel Catalin , Dumitrescu Otilia-Maria , Zaharia Alexandra Catalina , Pirvulescu Ruxandra Angela , Munteanu Mihnea , Tataru Calin Petru , Istrate Sinziana
Published: April 2022

Glaucoma is a vision threatening, not uncommon complication of eyes that have undergone pars plana vitrectomy with silicone oil endotamponade. Although most patients respond well to medical antiglaucoma therapy, there are refractory cases where surgery is required to control the intraocular pressure. This review, following a comprehensive literature search in the Medline database, aims to present the most important surgical techniques currently in use for glaucoma associated with silicone oil endotamponade and their indication depending on the mechanism of glaucoma. In cases of pupillary block, the presence of a patent iridotomy or iridectomy must be ensured, either by laser or surgically. When silicone oil is in excess and whenever the retinal status permits it, partial or complete removal of the silicone oil should be performed. Trabeculectomy has shown higher failure rates and more complications in these cases compared to other indications, so alternate methods are warranted. For very high intraocular pressures, glaucoma drainage devices and transscleral cyclophotocoagulation are the most used options, with good efficacy and safety profiles, although rarely they may have serious complications. The Ex-PRESS mini shunt has shown excellent results and lower rates of complications. For less important IOP elevations, minimally invasive glaucoma surgery and selective laser trabeculoplasty may be used, either alone or in conjunction with other methods.
Mean Platelet Volume as a Predictor of COVID-19 Severity: A Prospective Cohort Study in the Highlands of Peru
Authors: Quispe-Pari Jhosef Franck , Gonzales-Zamora Jose Armando , Munive-Dionisio Judith , Castro-Contreras Cristhian , Villar-Astete Abelardo , Kong-Paravicino Cesar , Vilcapoma-Balbin Pierina , Hurtado-Alegre Jorge
Published: April 2022

Introduction: Although 80% of symptomatic individuals with COVID-19 develop mild forms, it is the severe (15%) and critical (5%) forms that have the greatest impact in the hospital setting. Recognizing markers that can predict severe forms is essential, especially in high-altitude populations. Methods: We conducted a prospective cohort study at 3200 masl (meters above sea level) in a city in Peru to determine if MPV (mean platelet volume) level is a predictor of COVID-19 severity. Patients with mild/moderate disease were enrolled and followed for 21 days or until the development of severe disease (primary outcome). A bivariate analysis was used to identify variables associated with severe disease. A ROC analysis determined the best MPV (mean platelet count) cut-off to predict COVID-19 severity, and then, a multiple regression analysis was performed. Results: 64 patients were enrolled. The median age was 48.5 years (IQT 39–64.5) and the proportion of women was 51.6%, the most frequent symptoms were chest pain (73%), fever (71%), and dyspnea (67%). The median time to develop a severe form from the onset of symptoms was 11 days (IQT 10.5–13). The most common radiographic phase on CT scan (computed tomography) was progressive (60.38%). We observed that an MPV of more than 10.15 fL in the first week of disease predicted severity regardless of age and sex at high altitudes. Conclusions: MPV in the first week of the disease may predict severity in patients diagnosed with COVID-19 at high altitudes; however, we need prospective studies with a larger population and at a different altitude, levels to confirm these findings.
A Robust and Accurate Landing Methodology for Drones on Moving Targets
Authors: Keller Assaf , Ben-Moshe Boaz
Published: April 2022

This paper presents a framework for performing autonomous precise landing of unmanned aerial vehicles (UAVs) on dynamic targets. The main goal of this work is to design the methodology and the controlling algorithms that will allow multi-rotor drones to perform a robust and efficient landing in dynamic conditions of changing wind, dynamic obstacles, and moving targets. Unlike existing GNSS-based vertical landing solutions, the suggested framework does not rely on global positioning and uses adaptive diagonal approaching angle visual landing. The framework was designed to work on existing camera-drone platforms, without any need for additional sensors, and it was implemented using DJI’s API on Android devices. The presented concept of visual sliding landing (VSL) was tested on a wide range of commercial drones, performing hundreds of precise and robust autonomous landings on dynamic targets, including boats, cars, RC-boats, and RC-rovers.
Methodology for the Development of Hybrid Renewable Energy Systems (HRES) with Pumped Storage and Hydrogen Production on Lemnos Island
Authors: Agapitidou Anastasia-Alkmini , Skroufouta Sofia , Baltas Evangelos
Published: April 2022

The non-interconnected islands of Greece can benefit from the comprehensive use of RES to avoid water droughts and ensure energy autonomy. The present paper analyzes an HRES with two possible operating scenarios. Both of them include a wind park of 27.5 MW capacity, an 1175 m3/day desalination plant, and a 490,000 m3/day water tank in Lemnos, Greece. Regarding the wind power, 70% is used in the HRES, while the rest is channeled directly to the grid. The main difference comes down to how the wind energy is stored, either in the form of hydraulic energy or in the form of hydrogen. The lifespan of the system is 25 years, such as the produced stochastic series of rainfall, temperature, and wind of the area. Through the comparison of the operating scenarios, the following results arise: (i) the water needs of the island are fully covered and the irrigation needs have a reliability of 66%, in both scenarios. (ii) Considering the energy needs, the pumping storage seems to be the most reliable solution. (iii) However, depending on the amount of wind energy surplus, the use of hydrogen could produce more energy than the hydroelectric plant.
The Spatiotemporal Characteristics and Interactions between Urban Expansion and Tidal Flat Dynamics: A Case Study of Three Highly Urbanized Coastal Counties in the Southeastern United States
Authors: Xu Chao , Liu Weibo
Published: April 2022

Tidal flats are widely recognized as sentinels of coastal environment change, and are also the guardians for beachfront communities. As a result of urban expansion, tidal flats have increasingly received environmental pressures and the surrounding ecosystem has been functionally downgraded. However, the existing studies could not provide an effective method to identify and quantify the interactions between urban areas and tidal flats, which is essential work particularly for the coastal preservations in the United States. Aiming at this environmental crisis, we proposed an approach which quantifies the change patterns from a spatiotemporal perspective. To justify the rationality and feasibility of this approach, this study selected three highly urbanized coastal counties in the southeastern United States as the study area. We analyzed the annual dynamics during 1985~2015, and the generated spatiotemporal regularities were used to identify and quantify the correlations between urban expansion and tidal flat dynamics. This study not only justified that the coastal urban expansion could considerably damage the environment of tidal flats, but also verified an effective approach to investigate the correlations between urban expansion and tidal flat loss on a large spatiotemporal scale.
Extraction of Parallel-Coupled and End-Coupled TEM Resonator Networks from a Coupling Matrix in the Design of Coupled-Resonator Filters
Authors: Gruszczynski Slawomir , Wincza Krzysztof
Published: April 2022

The paper presents theoretical formulas for the extraction of TEM network parameters from coupling matrices. Along with resonator couplings, the circuits realizing external couplings are also considered. The most common coupling techniques are investigated, i.e., parallel-coupled half-wave-long resonators and end-coupled half-wave-long resonators, for which appropriate design equations are derived. The considered approach of filter design allows for introducing the equivalent circuit of the designed filter prior to the electromagnetic analysis of the coupled resonators. This, in turn, provides better control of the design process and allows for designing the filter in a step-by-step process while constantly controlling the filter response. Moreover, knowing the equivalent circuit, one can use the known methods of, e.g., coupled-line section design, in calculating the couplings between the resonators instead of looking for the correct solution solely based on the electromagnetic calculations. Additionally, comparison of the filter’s response obtained by the proposed numerical calculations versus the filter response obtained with classic network synthesis methods, is given. Finally, an exemplary filter is designed with the use of the proposed approach and measured to show the possible application of the derived theoretical formulas.
A Novel Buck Converter with Dual Loops Control Mechanism
Authors: Chou Hsiao-Hsing , Luo Wen-Hao , Chen Hsin-Liang , Wang San-Fu
Published: April 2022

This paper presents a novel buck converter with dual-loop control technology, which does not need to detect the inductor current directly. The structure of the control loops is easy to implement, one loop controls the output voltage, and the other controls the switching frequency. With the dual loops control mechanism, the output voltage and switching frequency can be accurately controlled only by measuring the output and input voltage, without sensing the inductor current. The buck converter can generate an output voltage of 1.0–2.5 V when the input voltage and load current are 3.0–3.6 V and 100–500 mA, respectively. The design was verified by SIMPLIS. The simulation results show that the switching frequency variation is less than 1% at the output voltage of 1.0–2.5 V. The recovery time is less than 1.5 μs during the load change. The circuit can be fabricated by using the TSMC 0.35μm 2P4M CMOS processes. The control scheme, theoretical analysis and circuit implementation are presented in this paper.
Employing the TAM Model to Investigate the Readiness of M-Learning System Usage Using SEM Technique
Authors: Almaiah Mohammed , Al-Otaibi Shaha , Lutfi Abdalwali , Almomani Omar , Awajan Arafat , Alsaaidah Adeeb , Alrawad Mahmoad , Awad Ali
Published: April 2022

During COVID-19, universities started to use mobile learning applications as one of the solutions to support distance learning. The readiness of universities to apply new systems, such as mobile learning applications, is considered one of the critical issues to ensure the system’s success. Determining the most important aspects of readiness to use mobile learning is a key step to adopt mobile learning in an effective way. To address this issue, this research aims to determine the most important determinants influencing mobile learning readiness by employing the Technology Acceptance Model (TAM). The Structural Equation Modelling (SEM) method was used to test the hypotheses in the proposed model. The results showed that the relationship between mobile learning readiness and awareness, IT infrastructure and top management support was positively significant. In conclusion, the findings will be of value to decision makers and mobile learning developers in universities to enhance the development of mobile learning applications. In addition, it may help facilitate and promote the usage of mobile learning applications among users.
Low-Dimensional-Approximate Model Based Improved Fuzzy Non-Singular Terminal Sliding Mode Control for Rigid-Flexible Manipulators
Authors: Xu Lisha , Qian Xiaoshan , Hu Rong , Zhang Yi , Deng Hua
Published: April 2022

The dynamic characteristics of rigid-flexible manipulators involve complex rigid-flexible coupling phenomena, which essentially comprise a nonlinear distributed parameter system with infinite degrees of freedom. Consequently, it results in challenges to the manipulator’s precise positioning. This study combined a state feedback module and a fuzzy non-singular terminal sliding mode to suppress vibration and deformation. Using the improved fuzzy strategy and non-singular terminal sliding mode control, an adaptive dynamic supplementary control law is proposed. The results based on MATLAB simulation and a built hardware experiment show that this method is effective and superior. While realizing the accurate positioning of the end of the manipulator, the vibration of the end of the flexible arm is significantly suppressed. This method has a high tracking performance, which enables accurate positioning of the manipulator terminal and provides strong robustness under the action of bounded external interference.
A Countermeasure Approach for Brute-Force Timing Attacks on Cache Privacy in Named Data Networking Architectures
Authors: Dogruluk Ertugrul , Macedo Joaquim , Costa Antonio
Published: April 2022

One key feature of named data networks (NDN) is supporting in-network caching to increase the content distribution for today’s Internet needs. However, previously cached contents may be threatened by side-channel timing measurements/attacks. For example, one adversary can identify previously cached contents by distinguishing between uncached and cached contents from the in-network caching node, namely the edge NDN router. The attacks can be mitigated by the previously proposed methods effectively. However, these countermeasures may be against the NDN paradigm, affecting the content distribution performance. This work studied the side-channel timing attack on streaming over NDN applications and proposed a capable approach to mitigate it. Firstly, a recent side-channel timing attack, designated by brute-force, was implemented on ndnSIM using the AT&T network topology. Then, a multi-level countermeasure method, designated by detection and defense (DaD), is proposed to mitigate this attack. Simulation results showed that DaD distinguishes between legitimate and adversary nodes. During the attack, the proposed DaD multi-level approach achieved the minimum cache hit ratio (≈0.7%) compared to traditional countermeasures (≈4.1% in probabilistic and ≈3.7% in freshness) without compromising legitimate requests.
Smart Energy and Intelligent Transportation Systems
Authors: Lam Albert Y. S. , Łazarz Bogusław , Peruń Grzegorz
Published: April 2022

With the Internet of things and various information and communication technologies, a city can manage its assets in a smarter way, constituting the urban development vision of a smart city [...]
Experimental Evaluation of a Full-Scale HVAC System Working with Nanofluid
Authors: Milanese Marco , Micali Francesco , Colangelo Gianpiero , de Risi Arturo
Published: April 2022

Nowadays, energy saving is considered a key issue worldwide, as it brings a variety of benefits: reducing greenhouse gas emissions and the demand for energy imports and lowering costs on a household and economy-wide level. Researchers and building designers are looking to optimize building efficiency by means of new energy technologies. Changes can also be made in existing buildings to reduce the energy consumption of air conditioning systems, even during operational conditions without dramatically modifying the system layout and have as low an impact as possible on the cost of the modification. These may include the usage of new heat transfer fluids based on nanofluids. In this work, an extended experimental campaign (from February 2020 to March 2021) has been carried out on the HVAC system of an educational building in the Campus of University of Salento, Lecce, Italy. The scope of the investigation was comparing the COP for the two HVAC systems (one with nanofluid and the other one without) operating concurrently during winter and summer: simultaneous measurements on the two HVAC systems show that the coefficient of performance (COP) with nanofluid increased on average by 9.8% in winter and 8.9% in summer, with average daily peaks of about 15%. Furthermore, the comparison between the performance of the same HVAC system, working in different comparable periods with and without nanofluids, shows a mean increase in COP equal to about 13%.
RuCo Alloy Nanoparticles Embedded into N-Doped Carbon for High Efficiency Hydrogen Evolution Electrocatalyst
Authors: Wang Cheng , Wang Yibo , Shi Zhaoping , Luo Wenhua , Ge Junjie , Xing Wei , Sang Ge , Liu Changpeng
Published: April 2022

For large-scale and sustainable water electrolysis, it is of great significance to develop cheap and efficient electrocatalysts that can replace platinum. Currently, it is difficult for most catalysts to combine high activity and stability. To solve this problem, we use cobalt to regulate the electronic structure of ruthenium to achieve high activity, and use carbon matrix to protect alloy nanoparticles to achieve high stability. Herein, based on the zeolitic imidazolate frameworks (ZIFs), a novel hybrid composed of RuCo alloy nano-particles and N-doped carbon was prepared via a facile pyrolysis-displacement-sintering strategy. Due to the unique porous structure and multi-component synergy, the optimal RuCo500@NC750 material in both acidic and alkaline media exhibited eminent HER catalytic activity. Notably, the 3-RuCo500@NC750 obtained a current density of 10 mA cm−2 at 22 mV and 31 mV in 0.5 M H2SO4 and 1.0 M KOH, respectively, comparable to that of the reference Pt/C catalyst. Furthermore, the Tafel slopes of the catalyst are 52 mV Dec−1 and 47 mV Dec−1, respectively, under acid and alkali conditions, and the catalyst has good stability, indicating that it has broad application prospects in practical electrolytic systems. This work contributes to understanding the role of carbon-supported polymetallic alloy in the electrocatalytic hydrogen evolution process, and provides some inspiration for the development of a high efficiency hydrogen evolution catalyst.
Full Current-Type Control-Based Hybrid Energy Storage System
Authors: Ren Jiahui , Lin Wenli , Liu Xinbo , He Shuiyuan , Dongye Zhonghao , Diao Lijun
Published: April 2022

With greater power density, a hybrid power source that combines supercapacitors and batteries has a wide range of applications in pulse-operated power systems. In this paper, a supercapacitor/battery semi-active hybrid energy storage system (HESS) with a full current-type control strategy is presented. The studied HESS is composed of batteries, supercapacitors, and a bidirectional buck–boost converter. The converter is controlled such that supercapacitors supply load power pulses, and batteries provide the power in steady state. To realize the fast compensation of the supercapacitors to the load power pulses, a power distribution module based on hysteresis control theory is designed in the control system. Moreover, the control strategy does not require the model parameters of the converter and supercapacitors, so the control system is simplified. A complete configuration scheme and cost analysis of the proposed HESS are also presented. Obtained results show that the proposed supercapacitor/battery semi-active HESS has good performance in terms of dynamic response, weight, and energy utilization coefficient (EUC).