bluuebunny/crossref_metadata_2025 huggingface dataset:
Soil organic matter turnover rates increase to match increased inputs in grazed grasslands
Authors: Stoner Shane W. , Hoyt Alison M. , Trumbore Susan , Sierra Carlos A. , Schrumpf Marion , Doetterl Sebastian , Baisden W. Troy , Schipper Louis A.
Published: August 2021

Managed grasslands have the potential to store carbon (C) and partially mitigate climate change. However, it remains difficult to predict potential C storage under a given soil or management practice. To study C storage dynamics due to long-term (1952–2009) phosphorus (P) fertilizer and irrigation treatments in New Zealand grasslands, we measured radiocarbon (14C) in archived soil along with observed changes in C stocks to constrain a compartmental soil model. Productivity increases from P application and irrigation in these trials resulted in very similar C accumulation rates between 1959 and 2009. The ∆14C changes over the same time period were similar in plots that were both irrigated and fertilized, and only differed in a non-irrigated fertilized plot. Model results indicated that decomposition rates of fast cycling C (0.1 to 0.2 year−1) increased to nearly offset increases in inputs. With increasing P fertilization, decomposition rates also increased in the slow pool (0.005 to 0.008 year−1). Our findings show sustained, significant (i.e. greater than 4 per mille) increases in C stocks regardless of treatment or inputs. As the majority of fresh inputs remain in the soil for less than 10 years, these long term increases reflect dynamics of the slow pool. Additionally, frequent irrigation was associated with reduced stocks and increased decomposition of fresh plant material. Rates of C gain and decay highlight trade-offs between productivity, nutrient availability, and soil C sequestration as a climate change mitigation strategy.
Neuroprotective properties of queen bee acid by autophagy induction
Authors: Martínez-Chacón Guadalupe , Paredes-Barquero Marta , Yakhine-Diop Sokhna M.S , Uribe-Carretero Elisabet , Bargiela Ariadna , Sabater-Arcis María , Morales-García José , Alarcón-Gil Jesús , Alegre-Cortés Eva , Canales-Cortés Saray , Rodríguez-Arribas Mario , Camello Pedro Javier , Pedro José Manuel Bravo-San , Perez-Castillo Ana , Artero Rubén , Gonzalez-Polo Rosa A. , Fuentes José M. , Niso-Santano Mireia
Published: August 2021

Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends longevity in several animal models. Therefore, there is a great interest in the identification of effective autophagy enhancers with potential nutraceutical or pharmaceutical properties to ameliorate age-related diseases, such as neurodegenerative disorders, and/or promote longevity. Queen bee acid (QBA, 10-hydroxy-2-decenoic acid) is the major fatty acid component of, and is found exclusively in, royal jelly, which has beneficial properties for human health. It is reported that QBA has antitumor, anti-inflammatory, and antibacterial activities and promotes neurogenesis and neuronal health; however, the mechanism by which QBA exerts these effects has not been fully elucidated. The present study investigated the role of the autophagic process in the protective effect of QBA. We found that QBA is a novel autophagy inducer that triggers autophagy in various neuronal cell lines and mouse and fly models. The beclin-1 (BECN1) and mTOR pathways participate in the regulation of QBA-induced autophagy. Moreover, our results showed that QBA stimulates sirtuin 1 (SIRT1), which promotes autophagy by the deacetylation of critical ATG proteins. Finally, QBA-mediated autophagy promotes neuroprotection in Parkinson’s disease in vitro and in a mouse model and extends the lifespan of Drosophila melanogaster. This study provides detailed evidences showing that autophagy induction plays a critical role in the beneficial health effects of QBA.
Working from Home During Covid-19: Doing and Managing Technology-enabled Social Interaction With Colleagues at a Distance
Authors: Lal Banita , Dwivedi Yogesh K. , Haag Markus
Published: August 2021

With the overnight growth in Working from Home (WFH) owing to the pandemic, organisations and their employees have had to adapt work-related processes and practices quickly with a huge reliance upon technology. Everyday activities such as social interactions with colleagues must therefore be reconsidered. Existing literature emphasises that social interactions, typically conducted in the traditional workplace, are a fundamental feature of social life and shape employees’ experience of work. This experience is completely removed for many employees due to the pandemic and, presently, there is a lack of knowledge on how individuals maintain social interactions with colleagues via technology when working from home. Given that a lack of social interaction can lead to social isolation and other negative repercussions, this study aims to contribute to the existing body of literature on remote working by highlighting employees’ experiences and practices around social interaction with colleagues. This study takes an interpretivist and qualitative approach utilising the diary-keeping technique to collect data from twenty-nine individuals who had started to work from home on a full-time basis as a result of the pandemic. The study explores how participants conduct social interactions using different technology platforms and how such interactions are embedded in their working lives. The findings highlight the difficulty in maintaining social interactions via technology such as the absence of cues and emotional intelligence, as well as highlighting numerous other factors such as job uncertainty, increased workloads and heavy usage of technology that affect their work lives. The study also highlights that despite the negative experiences relating to working from home, some participants are apprehensive about returning to work in the traditional office place where social interactions may actually be perceived as a distraction. The main contribution of our study is to highlight that a variety of perceptions and feelings of how work has changed via an increased use of digital media while working from home exists and that organisations need to be aware of these differences so that they can be managed in a contextualised manner, thus increasing both the efficiency and effectiveness of working from home.
Influence of thermomechanical processing parameters on critical temperatures to develop an Advanced High-Strength Steel microstructure
Authors: Romano-Acosta L. F. , García-Rincon O. , Pedraza J. P. , Palmiere E. J.
Published: August 2021

A good selection of the thermomechanical processing parameters will optimize the function of alloying elements to get the most of mechanical properties in Advanced High-Strength Steels for automotive components, where high resistance is required for passenger safety. As such, critical processing temperatures must be defined taking into account alloy composition, in order for effective thermomechanical processing schedules to be designed. These critical temperatures mainly include the recrystallization stop temperature (T5%) and the transformation temperatures (Ar1, Ar3, Bs, etc.). These critical processing temperatures were characterized using different thermomechanical conditions.T5%was determined through the softening evaluation on double hit tests and the observation of prior austenite grain boundaries on the microstructure. Phase transformation temperatures were measured by dilatometry experiments at different cooling rates. The results indicate that the strain per pass and the interpass time will influence the most on the determination ofT5%. The range of temperatures between the recrystallized and non-recrystallized regions can be as narrow as 30 °C at a higher amount of strain. The proposed controlled thermomechanical processing schedule involves getting a severely deformed austenite with a high dislocation density and deformation bands to increase the nucleation sites to start the transformation products. This microstructure along with a proper cooling strategy will lead to an enhancement in the final mechanical properties of a particular steel composition.
Smart home modification design strategies for ageing in place: a systematic review
Authors: Ma Chuan , Guerra-Santin Olivia , Mohammadi Masi
Published: August 2021

This research explores current strategies and approaches directed to integrate innovative technologies in the home modification process to support independent living and ageing in place. The systematic review considered studies conducted from the perspective of architecture, smart technology, and gerontology. Scientific databases of related disciplines (e.g. Scopus, Web of Science, Engineer village, Google Scholar, Crossref) were searched and supplemented by hand search method. Thirty-three out of 2594 articles were analysed from three perspectives: the framework of the smart home environment for ageing in place, the smart home modification process, and problems and countermeasures of independent living. The result shows that both home modification and smart technologies can support older adults’ independent living, especially with fall prevention and indoor accessibility. Technologies deployed in older adults’ homes are transiting from manual assistive technology to more intelligent devices, and the notion of the robotic home has emerged. According to existing practices, universal design is an extensively adopted strategy for smart home design and modification. However, in most cases, universal design is used as a retrofitting guideline for general home settings rather than specifically for smart homes. The fundamental requirements in smart home modification phases are customisation, minimum life interference, and extensible technologies to cope with the ageing process.
Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?
Authors: Reye Gina , Huang Xuan , Haupt Larisa M. , Murphy Ryan J. , Northey Jason J. , Thompson Erik W. , Momot Konstantin I. , Hugo Honor J.
Published: August 2021

Regions of high mammographic density (MD) in the breast are characterised by a proteoglycan (PG)-rich fibrous stroma, where PGs mediate aligned collagen fibrils to control tissue stiffness and hence the response to mechanical forces. Literature is accumulating to support the notion that mechanical stiffness may drive PG synthesis in the breast contributing to MD. We review emerging patterns in MD and other biological settings, of a positive feedback cycle of force promoting PG synthesis, such as in articular cartilage, due to increased pressure on weight bearing joints. Furthermore, we present evidence to suggest a pro-tumorigenic effect of increased mechanical force on epithelial cells in contexts where PG-mediated, aligned collagen fibrous tissue abounds, with implications for breast cancer development attributable to high MD. Finally, we summarise means through which this positive feedback mechanism of PG synthesis may be intercepted to reduce mechanical force within tissues and thus reduce disease burden.
Is There a Long-Term Criminogenic Effect of the Exposure to a Paternal Conviction During Upbringing? An Analysis of Full Siblings Using Swedish Register Data
Authors: Sivertsson Fredrik , Carlsson Christoffer , Hoherz Andreas
Published: August 2021

Objectives

The current study analyzed the association between a final paternal conviction that occurred sometime 10 years prior to birth through age 14 and subsequent child conviction risk to age 25.

Methods

We used Swedish register-based data on a two-generation dataset originating from a parental generation born in 1953. We employed a combination of population-averaged models that controlled for measured confounding together with an analysis of full siblings that ruled out unmeasured confounding shared between full siblings.

Results

The results showed that boys, but not girls, who were exposed to a paternal conviction during upbringing had an increased risk of being convicted themselves, net of measured and unmeasured familial confounds. There was, however, little indication for an age-effect at the time of a final paternal conviction, and there were no significant differences in violent crime between exposure-discordant siblings.

Conclusions

The results provide evidence for an effect of the exposure to a paternal conviction on child subsequent conviction risk that cannot merely be explained by familial factors shared between full siblings. These results are, however, conditional on gender and on the type of criminal outcome.
Birthing #blackboyjoy: Black Midwives Caring for Black Mothers of Black Boys During Pregnancy and Childbirth
Authors: Goode Keisha L. , Bernardin Arielle
Published: August 2021

Background

Structural racism mediates all aspects of Black life. The medicalization of pregnancy and childbirth, and its detrimental impacts on Black birth, is well documented. The Black Lives Matter movement has elevated the national consciousness on all aspects of Black life, but significant attention has been directed toward the murder and dehumanization of Black men and boys. Black midwives, caring for Black people, using the Midwives Model of Care© which consistently demonstrates its efficacy and better outcomes for Black people, are uniquely positioned to witness the physical and psychosocial experiences of birthing Black boys in America.

Methods

Between 2011 and 2013, the first author conducted interviews with 22 Black midwives to understand their perceptions of, and experiences in, predominantly white midwifery education programs and professional organizations. Convenience and snowball sampling were used. This paper investigates previously unreported and unexamined data from the original study by focusing on the witness and insight of nine midwives who provided care for Black mothers of boys during pregnancy and childbirth.

Findings

The data presented three themes: It’s a Boy: On Restlessness and Complicated Uneasiness; Desensitization of Black Death; and, Physiological Impacts of Toxic Stress.

Conclusions

The findings demonstrate that caring for Black people must be simultaneously theorized and executed within an anti-racist, relationship-centered, reproductive justice framework. Black midwives are uniquely positioned to do this work. Greater attention, in practice and in research, is needed to investigate the birth experiences of Black mothers of boys.
The matter of motivating reasons
Authors: Cunningham J. J.
Published: August 2021

It is now standard in the literature on reasons and rationality to distinguish normative reasons from motivating reasons. Two issues have dominated philosophical theorising concerning the latter: (i) whether we should think of them as certain (nonfactive) psychological states of the agent—the dispute over Psychologism; and (ii) whether we should say that the agent can ϕ for the reason that p only if p—the dispute over Factivism. This paper first introduces a puzzle: these disputes look very much like merely verbal disputes about the meaning of phrases like ‘S’s reason’ in motivating reasons ascriptions, and yet charity requires us to think that something substantive is afoot. But what? The second aim of the paper is to extract substantive theses from certain natural argument for Psychologism and Anti-Factivism—theses which are versions of a Cartesian view of the nature and normative structure of rationality. The paper ends by arguing against these substantive theses on phenomenological and ethical grounds. The upshot is that proponents of Psychologism and Anti-Factivism are either engaged in the project of defending merely verbal theses or they’re engaged in the project of defending false substantive ones.
A new take on voice: the influence of BlackRock’s ‘Dear CEO’ letters
Authors: Pawliczek Andrea , Skinner A. Nicole , Wellman Laura A.
Published: August 2021

Abstract

We examine whether broad-based public engagement by institutional investors influences the behavior of portfolio firms. We investigate this question in the context of BlackRock’s annual Dear CEO letter, which in recent years has called for portfolio firms to acknowledge and quantify the impact of environmental and regulatory factors on their firms. We find that portfolio firms’ disclosures during the post-letter period reflect topics similar to those discussed in the letters, controlling for a variety of firm and disclosure characteristics and the occurrence of private engagements. Moreover, BlackRock appears to value these additional disclosures, as it more often votes with management on shareholder proposals during subsequent annual shareholder meetings. Finally, motivated by BlackRock’s attempts to mobilize firms toward its specific policy recommendations, we also provide some evidence that firms’ lobbying efforts during the post-letter period become more aligned with the issues highlighted in the letter, especially when firms’ share BlackRock’s policy preferences ex ante. Taken together, our evidence suggests that portfolio firms are responsive to BlackRock’s public engagement efforts.
Empowering her guardians to nurture our Ocean’s future
Authors: Fischer Mibu , Maxwell Kimberley , Nuunoq  , Pedersen Halfdan , Greeno Dean , Jingwas Nang , Graham Blair Jamie , Hugu Sutej , Mustonen Tero , Murtomäki Eero , Mustonen Kaisu
Published: August 2021

Coastal Indigenous and Traditional communities are starting to see changes to their lives from climate change, whether this is from species range changes or displacement from land changes. For many of these communities, the ability to adequately adapt to these changes is limited by the governance structures they are required to live within, which differ from their customary practices and culture. In November 2019, a group of Indigenous and Traditional Peoples, attended the Future Seas 2030 workshop and discussed the consequences of climate change, the biggest barriers for their communities, and barriers for using traditional knowledge in order to contribute towards a more sustainable future that in the end will benefit all of earth’s people. The aim of this workshop was to highlight and give a voice to the various backgrounds and real-life situations impacting on some of the world’s Indigenous and Traditional communities whose connection with the oceans and coasts have been disrupted. This paper presents these issues of oppression, colonisation, language and agency, making it difficult for these groups to contribute to the current management of oceans and coasts, and asks scientists and practitioners in this space to be allies and enable the needed shift to earth’s guardians taking a leading role in nurturing her for our future.
Bruce Merrifield centennial: pioneer of chemical synthesis on solid matrix
Authors: Hargittai Istvan
Published: August 2021

Bruce Merrifield (1921‒2006) was an American biochemist who, at the Rockefeller Institute, invented a highly efficient technique for producing peptides and proteins in the early 1960s. He was awarded the Nobel Prize in Chemistry in 1984. We remember this highly original, low-profile contributor to chemistry on the occasion of the one hundredth anniversary of his birth.
Neutrophil activation and circulating neutrophil extracellular traps are increased in venous thromboembolism patients for at least one year after the clinical event
Authors: Zapponi Kiara C. S. , Orsi Fernanda A. , Cunha José Luiz R. , de Brito Ingrid R. , Romano Anna Virginia C. , Bittar Luis Fernando , De Paula Erich Vinicius , Penteado Carla F. , Montalvão Silmara , Annichino-Bizzacchi Joyce Maria
Published: August 2021

Neutrophil activation and neutrophil extracellular traps (NETs) have been associated with the pathogenesis of venous thromboembolism (VTE). Considering VTE-associated chronic sequelae, which suggest that some pathological mechanisms remain after the acute episode, we investigated whether neutrophil activation is increased in patients with a prior VTE at least one year before this investigation. Thirty-seven patients with prior VTE and 37 individuals with no history of VTE were included. Neutrophil activity was evaluated by the expression of the adhesive molecule activation-specific epitopes LFA-1 (CD11a) and MAC-1 (CD11b), chemotaxis, reactive oxygen species (ROS) and by MPO-DNA complexes as markers of NETs. The adhesive molecules sICAM-1 and sVCAM-1, involved in the cross talk between neutrophil and endothelial cells, were also evaluated. Patient neutrophils presented increased CD11a expression before and after TNF-α stimulus, whereas increased CD11b expression was observed only after TNF-α stimulus, as compared to controls. Neutrophil chemotaxis on both, basal state and after IL-8 stimulus, on circulating levels of sICAM-1 and sVCAM-1, and on MPO-DNA complexes were also increased in VTE patients. ROS release was similar between patients and controls. This is, to our knowledge, the first study to investigate neutrophil inflammatory activity in VTE patients a long period after an acute event (approximately 2 years). The results showed altered neutrophil activation patterns in these patients. While activated neutrophils can cause endothelial activation and injury, the activated endothelium can induce the release of NETs with consequent endothelial cytotoxicity, creating a vicious cycle of activation between neutrophils and endothelium that can lead to thrombosis.

Graphical abstract

VTE patients (approximately 2 years after the clinical event) present an altered neutrophil activation state evidenced by increased activity of the LFA-1 and Mac-1 adhesive molecules, as well as increased chemotaxis and circulating levels of NETs remnants. Circulating levels of ICAM-1 and VCAM-1, which are endothelial adhesive molecules, are also increased in VTE patients, suggesting not only an exacerbated endothelial activation and dysfunction, but also an interaction of the neutrophil adhesive molecules with their endothelial ligands, favoring the migration process of neutrophil.
Continuous Flow Friedel–Crafts Alkylation Catalyzed by Silica Supported Phosphotungstic Acid: An Environmentally Benign Process
Authors: Császár Zsófia , Juzsakova Tatjána , Jakab Miklós , Balogh Szabolcs , Szegedi Ágnes , Solt Hanna , Hancsók Jenő , Bakos József , Farkas Gergely
Published: August 2021

Six silica-supported phosphotungstic acid catalysts (PTA/SiO2) of different composition (20–70 wt% PTA content) have been synthesized and characterized by elemental analysis, BET, BJH, NH3-TPD methods, FT-IR spectroscopy of adsorbed pyridine and 1H MAS NMR techniques. The new composite catalysts were first applied in the Friedel–Crafts alkylation of toluene with 1-octene as a benchmark process under batch conditions in order to screen their activity and recyclability. The combined analytical techniques together with the catalytic studies enabled the identification of the main factors affecting the activity of the catalysts. Based on these preliminary experiments, the best performing catalyst system (50 wt% PTA/SiO2) was investigated in continuous flow mode using an in-house-made flow reactor. The thorough screening of the reaction conditions (temperature, toluene/1-octene molar ratio and flow rate) provided firm evidence that the 50 wt% PTA/SiO2 composite is highly active, selective and stable catalyst under mild reaction conditions even at elevated flow rate. Additionally, the catalyst used in the flow mode could successfully be regenerated and reused in the alkylation process.
Conflict adaptation and related neuronal processing in Parkinson’s disease
Authors: Rodriguez-Raecke Rea , Schrader Christoph , Tacik Pawel , Dressler Dirk , Lanfermann Heinrich , Wittfoth Matthias
Published: August 2021

Non-motor symptoms like cognitive impairment are a huge burden for patients with Parkinson’s disease. We examined conflict adaptation by using the congruency sequence effect as an index of adaptation in 17 patients with Parkinson’s disease and 18 healthy controls with an Eriksen flanker task using functional magnet resonance imaging to reveal possible differences in executive function performance. We observed overall increased response times in patients with Parkinson’s disease compared to healthy controls. A flanker interference effect and congruency sequence effect occurred in both groups. A significant interaction of current and previous trial type was revealed, but no effect of response sequence concerning left or right motor responses. Therefore, top-down conflict monitoring processes are likely the main contributors leading to the congruency sequence effect in our paradigm. In both groups incongruent flanker events elicited activation in the middle temporal gyrus, inferior parietal cortex, dorsolateral prefrontal cortex and the insula in contrast to congruent flanker events. A psychophysiological interactions analysis revealed increased functional connectivity of inferior parietal cortex as a seed to the left prefrontal thalamus during incongruent vs. congruent and neutral stimuli in patients with Parkinson’s disease that may reflect compensatory facilitating action selection processes. We conclude that patients with Parkinson’s disease exhibit conflict adaptation comparable to healthy controls when investigated while receiving their usual medication.
Riding the waves: the ongoing impact of COVID-19 on a national surgical training cohort
Authors: Hennessy Orla , Fowler Amy Lee , Hennessy Conor , Brinkman David , Hogan Aisling , Nugent Emmeline , Joyce Myles
Published: August 2021

Background

The World Health Organisation declared a global pandemic on the 11 March 2020 resulting in implementation of methods to contain viral spread, including curtailment of all elective and non-emergent interventions. Many institutions have experienced changes in rostering practices and redeployment of trainees to non-surgical services. Examinations, study days, courses, and conferences have been cancelled. These changes have the potential to significantly impact the education and training of surgical trainees.

Aim

To investigate the impact of the COVID-19 pandemic on training, educational, and operative experiences of Irish surgical trainees.

Methods

Surgical trainees were surveyed anonymously regarding changes in working and educational practices since the declaration of the COVID-19 pandemic on 11 March 2020. The survey was circulated in May 2020 to both core and higher RCSI surgical trainees, when restrictions were at level five. Questions included previous and current access to operative sessions as well as operative cases, previous and current educational activities, access to senior-led training, and access to simulation-/practical-based training methods. A repeat survey was carried out in October 2020 when restrictions were at level two.

Results

Overall, primary and secondary survey response rates were 29% (n = 98/340) and 19.1% (n = 65/340), respectively. At the time of circulation of the second survey, the number of operative sessions attended and cases performed had significantly improved to numbers experienced pre-pandemic (p < 0.0001). Exposure to formal teaching and education sessions returned to pre-COVID levels (p < 0.0001). Initially, 23% of trainees had an examination cancelled; 53% of these trainees have subsequently sat these examinations. Of note 27.7% had courses cancelled, and 97% of these had not been rescheduled.

Conclusion

Surgical training and education have been significantly impacted in light of COVID-19. This is likely to continue to fluctuate in line with subsequent waves. Significant efforts have to be made to enable trainees to meet educational and operative targets.
The peri- and intratumoral immune cell infiltrate and PD-L1 status in invasive squamous cell carcinomas of the penis
Authors: Müller T. , Demes M. , Lehn A. , Köllermann J. , Vallo S. , Wild P. J. , Winkelmann R.
Published: August 2021

Introduction

Penile carcinomas are rare tumors throughout Europe. Therefore, little attention is drawn to this disease. That makes it important to study tumor-associated key metrics and relate these to known data on penile neoplasias.

Materials and methods

A cohort of 60 well-defined penile invasive carcinomas with known human papillomavirus (HPV) infection status was investigated. Data on tumor type, grading and staging were recorded. Additionally, data on the peri- and intratumoral immune cell infiltrate in a semiquanititave manner applying an HE stain were assessed.

Results

Our study showed a significant correlation of immune cell infiltrate and pT stage with overall survival. Therefore, in a subset of tumors, PD-L1 staining was applied. For tumor proportion score (TPS), 26 of 30 samples (87%) were scored >0%. For the immune cell score (IC), 28 of 30 samples (93%) were defined as >0% and for CPS, 29 of 30 samples (97%) scored >0. PD-L1 expression was not associated with overall survival.

Conclusion

PD-L1 is expressed in penile carcinomas, providing a rationale for targeted therapy with checkpoint inhibitors. We were able to show that immune reaction appears to be prognostically relevant. These data enhance the need for further studies on the immune cell infiltrate in penile neoplasias and show that PD-L1 expression is existent in our cohort, which may be a potential target for checkpoint inhibitor therapy.
Situating Mindfulness, Part 1: Early Buddhism and Scientific Research in Psychology
Authors: Anālayo Bhikkhu
Published: August 2021

As the first of three articles, the present essay explores the character of selected aspects of early Buddhism in order to assess its potential relevance as a reference point for those engaged in research on mindfulness in psychology. The exploration, which proceeds in critical dialog with suggestions made by Donald Lopez Jr. and Evan Thompson, covers the topics of the Buddha’s omniscience, Buddhist cosmology, the notion of karma, the role of rebirth, the past lives of the Buddha, and the role of religious authority vis-à-vis the scope of personal investigation in early Buddhist thought. The present paper is meant to serve as a corrective to an apparent tendency in recent scholarship, as part of an in itself deserved criticism of exaggerated positions taken by Buddhist modernists, to overlook or even deny rational dimensions of Buddhist thought, here in particular taken up from the viewpoint of its earliest phase. This tendency appears at times to be based on a lack of historical perspective or understanding of Buddhist doctrines and their development.
Determining infrastructure requirements for an air taxi service at Cologne Bonn Airport
Authors: Feldhoff Eva , Soares Roque Gonçalo
Published: August 2021

The worldwide increasing population density in major urban centres poses great challenges for transportation systems. Air taxi services could be a solution to this growing problem by bringing the existing transportation system to the three dimensional space. This paper analyzes the challenges and requirements of developing a vertiport intended for the use of air taxis at Cologne Bonn Airport. This research was conducted with the information available at the time of writing, for which a basis scenario is defined for the Cologne Bonn Airport where important aspects of an air taxi service are determined such as passenger demand and possible vehicles. The main aspects analysed were the requirements on the vertiport infrastructure and its location, as well as the requirements on passenger processing. For the defined basis scenario, results show that the preferential locations to develop a vertiport at Cologne Bonn Airport are the roof top levels of parking garages P2 and P3. Furthermore, it is shown that given the estimated passenger demand, a very high utilization factor of the defined infrastructure is to be expected. This paper provides a starting point for the development of an air taxi service at Cologne Bonn Airport. Further research is needed in key issues such as the financial aspects of an air taxi service, its integration into the current operating scenario of the Cologne Bonn Airport and the approval process for an air taxi service and the vertiport itself.
Towards the Environmental Minimum
Authors: Theil Stefan
Published: August 2021

Pervasive environmental harm that disproportionately impacts vulnerable members of society is left largely unregulated across the globe despite existing legal commitments to human rights and environmental protection in many states. To address this shortcoming, Stefan Theil proposes a new normative framework for environmental protection through human rights law. In clear and accessible prose, he demonstrates how such a human rights-based approach can strengthen environmental protection without requiring radical departures from established protection regimes and legal principles. The environmental minimum developed in the book translates the general and abstract commitments of states into specific and practical measures that protect the environment. The framework develops the doctrine of international, regional, and domestic courts, analysed through an innovative approach that improves contextual awareness. This book is thus a valuable resource for lawyers, social scientists, political theorists, environmental and human rights advocates.
True by Default
Authors: GRIFFITH AARON M.
Published: August 2021

This paper defends a new version of truthmaker non-maximalism. The central feature of the view is the notion of a default truth-value. I offer a novel explanation for default truth-values and use it to motivate a general approach to the relation between truth-value and ontology, which I call truth-value-maker theory. According to this view, some propositions are false unless made true, whereas others are true unless made false. A consequence of the theory is that negative existential truths need no truthmakers and that positive existential falsehoods need no falsemakers.
Automated facial recognition and policing: a Bridge too far?
Authors: Purshouse Joe , Campbell Liz
Published: August 2021

Automated facial recognition (AFR) is perhaps the most controversial policing tool of the twenty-first century. Police forces in England and Wales, and beyond, are using facial recognition in various contexts, from evidence gathering to the identification and monitoring of criminal suspects. Despite uncertainty regarding its accuracy, and widespread concerns about its impact on human rights and broader social consequences, the rise of police facial recognition continues unabated by law. Both the Government and the domestic courts were satisfied that police use of this technology is regulated adequately by existing statutory provisions regulating the processing of data and police surveillance generally. That is, until the recent judgment of the Court of Appeal in R (Bridges) v Chief Constable of South Wales Police and Others [2020] EWCA Civ 1058, where it was held that the respondent's use of AFR was unlawful. This paper provides an analysis of AFR, reflecting on the outcome of that case and evaluates its nuanced findings. We suggest that the judgment leaves considerable room for police AFR to continue with only minor, piecemeal amendment to the legal framework. Drawing on comparative experience and relevant socio-legal scholarship, we argue that the relatively unfettered rise of police facial recognition in England and Wales illuminates deeper flaws in the domestic framework for fundamental human rights protection and adjudication, which create the conditions for authoritarian policing and surveillance to expand.
Good riddance to bad government? Institutional performance voting in Swedish municipalities
Authors: Broms Rasmus
Published: August 2021

Electoral accountability is widely considered to be an essential component for maintaining the quality of a polity’s institutions. Nevertheless, a growing body of research has found weak or limited support for the notion that voters punish political corruption, a central but partial aspect of institutional quality. In order to capture the full range of institutional dysfunction an electorate should be incentivised to punish, I further the concept of institutional performance voting, that is, voting on institutional quality as a whole. Using a novel data set on performance audit reports in Swedish municipalities between 2003 and 2014, I find that audit critique is associated with a statistically significant but substantively moderate electoral loss of about a percentage point for mayoral parties, while simultaneously associated with a 14 percentage point decrease in their probability of reelection.
Democratic Backsliding and the Instrumentalization of Women's Rights in Turkey
Authors: Arat Yeşim
Published: August 2021

This article examines the instrumentalization of women's rights and the transformation of the gender rights regime in the context of democratic backsliding in Turkey. I show how the Islamically rooted Justice and Development Party governments and their allies used women's rights in constructing authoritarian rule and promoting a conservative gender agenda. The governing elites had different needs at different political stages and instrumentalized women's rights to meet those needs. First, they needed to legitimize their rule in a secular context, so they expanded liberal laws on women's rights. Second, in the process of backsliding, they sought to construct and legitimize their conservative ideology, so they reinterpreted existing laws to promote conservative goals. Finally, they wanted to mobilize conservative women in support of the newly authoritarian regime, so they built new institutions and marginalized existing women's NGOs. The article contributes to the literature on regime types and gender rights by shifting the focus from regime type to regime change.
ANTIATTICISTη 6 VALENTE (ἡσύχιος): A PROPOSAL FOR A DIFFERENT TEXTUAL ARRANGEMENT
Authors: Tribulato Olga
Published: August 2021

TheAntiatticistlexicon has a short lemma on the adjective ἡσύχιος ‘silent, quiet’ which has suffered heavy shortening and possibly interpolation. The present article argues that the text of this lemma should be edited as it stands in cod. Coisl. 345 and should not be changed. The entry and the mutual relationship between the words it includes should be assessed in the light of theAntiatticist's approach to classical Greek, and of the Byzantine reception of the lexicon and its contents.
Turbulence Properties of a Deep‐Sea Hydrothermal Plume in a Time‐Variable Cross‐Flow: Field and Model Comparisons for Dante in the Main Endeavour Field
Authors: Adams Ian , Di Iorio Daniela
Published: August 2021

A large eddy simulation is used to study a high temperature hydrothermal vent plume in a stratified and tidally modulated crossflow, in order to identify its turbulence and mixing characteristics. The model parameters and source conditions that are comparable to the vertical velocity and refractive index fluctuations measured 20 m above the Dante sulfide mound in the Main Endeavour vent Field are a heat transport of 50 MW over a cross‐sectional area of 4 × 4.5 m2. With these model source conditions and output results taken at 20 m above the source with 1 Hz sampling, the shear production of turbulent kinetic energy (TKE), the vertical transport of TKE, and the buoyancy production/dissipation are quantified showing that shear production dominates. Similarly, thermal variance production, and its vertical transport, is also quantified showing that the advective term dominates. Because of enhanced entrainment of ambient water into the plume during strong crossflows, all mean and turbulent quantities show tidally modulated values. Assuming steady state, the dissipation rates are evaluated. During strong crossflows, the tilting of the vertical velocity contours and isotherms plays a critical role in the stability of the plume and in creating high shear and thermal gradients on the upstream side of the plume center axis. These dissipation rates are used to quantify the refractive index fluctuations, and given the high thermal dissipation quantity it is the main contributing factor in acoustic forward scatter.
Explaining Thermal Tides in the Upper Atmosphere During the 2015 El Ni�o
Authors: Shultz David
Published: August 2021

Increased tropospheric heating and reduced dissipation combine to explain an anomalously large thermal tide.
Sympathetic-transduction in untreated hypertension
Authors: Kobetic Matthew D. , Burchell Amy E. , Ratcliffe Laura E. K. , Neumann Sandra , Adams Zoe H. , Nolan Regina , Nightingale Angus K. , Paton Julian F. R. , Hart Emma C.
Published: August 2021

Transduction of muscle sympathetic nerve activity (MSNA) into vascular tone varies with age and sex. Older normotensive men have reduced sympathetic transduction so that a given level of MSNA causes less arteriole vasoconstriction. Whether sympathetic transduction is altered in hypertension (HTN) is not known. We investigated whether sympathetic transduction is impaired in untreated hypertensive men compared to normotensive controls. Eight untreated hypertensive men and 10 normotensive men (age 50 ± 15 years vs. 45 ± 12 years (mean ± SD); p = 0.19, body mass index (BMI) 24.7 ± 2.7 kg/m2 vs. 26.0 ± 4.2 kg/m2; p = 0.21) were recruited. MSNA was recorded from the peroneal nerve using microneurography; beat-to-beat blood pressure (BP; Finapres) and heart rate (ECG) were recorded simultaneously at rest for 10 min. Sympathetic-transduction was quantified using a previously described method. The relationship between MSNA burst area and subsequent diastolic BP was measured for each participant with the slope of the regression indicating sympathetic transduction. MSNA was higher in the hypertensive group compared to normotensives (73 ± 17 bursts/100 heartbeats vs. 49 ± 19 bursts/100 heart bursts; p = 0.007). Sympathetic-transduction was lower in the hypertensive versus normotensive group (0.04%/mmHg/s vs. 0.11%/mmHg/s, respectively; R = 0.622; p = 0.006). In summary, hypertensive men had lower sympathetic transduction compared to normotensive individuals suggesting that higher levels of MSNA are needed to cause the same level of vasoconstrictor tone.
Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK
Authors: Moriarty Yvonne , Lau Mandy , Sewell Bernadette , Trubey Rob , Quinn-Scoggins Harriet , Owen Sioned , Padgett Louise , Kolovou Vasiliki , Hepburn Julie , Buckle Peter , Playle Rebecca , Townson Julia , Robling Michael , Gilbert Stephanie , Dimitropoulou Polyxeni , Edwards Adrian , Mitchell Caroline , Matthews Maura , Smits Stephanie , Wood Fiona , Neal Richard D. , Brain Kate ,   ABACus study team, Jones Mari , Farr Angela
Published: August 2021

Background

Cancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation.

Methods

This is a randomised controlled trial involving adults aged 40+ years recruited in community and healthcare settings in deprived areas of South Yorkshire and South-East Wales. Intervention: personalised behavioural advice facilitated by a trained lay advisor. Control: usual care. Follow-up at two weeks and six months post-randomisation. Primary outcome: total cancer symptom recognition score two weeks post-randomisation.

Results

Two hundred and thirty-four participants were randomised. The difference in total symptom recognition at two weeks [adjusted mean difference (AMD) 0.6, 95% CI: −0.03, 1.17,p = 0.06] was not statistically significant. Intervention participants reported increased symptom recognition (AMD 0.8, 95% CI: 0.18, 1.37,p = 0.01) and earlier intended presentation (AMD −2.0, 95% CI: −3.02, −0.91,p < 0.001) at six months. “Lesser known” symptom recognition was higher in the intervention arm (2 weeks AMD 0.5, 95% CI: 0.03, 0.97 and six months AMD 0.7, 95% CI: 0.16, 1.17). Implementation cost per participant was £91.34, with no significant between-group differences in healthcare resource use post-intervention.

Conclusions

Improved symptom recognition and earlier anticipated presentation occurred at longer-term follow-up. The ABACus Health Check is a viable low-cost intervention to increase cancer awareness in socioeconomically deprived communities.

Clinical trial registration

ISRCTN16872545.
Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting
Authors: Rufo Nicole , Korovesis Dimitris , Van Eygen Sofie , Derua Rita , Garg Abhishek D. , Finotello Francesca , Vara-Perez Monica , Rožanc Jan , Dewaele Michael , de Witte Peter A. , Alexopoulos Leonidas G. , Janssens Sophie , Sinkkonen Lasse , Sauter Thomas , Verhelst Steven H. L. , Agostinis Patrizia
Published: August 2021

Mounting evidence indicates that immunogenic therapies engaging the unfolded protein response (UPR) following endoplasmic reticulum (ER) stress favor proficient cancer cell-immune interactions, by stimulating the release of immunomodulatory/proinflammatory factors by stressed or dying cancer cells. UPR-driven transcription of proinflammatory cytokines/chemokines exert beneficial or detrimental effects on tumor growth and antitumor immunity, but the cell-autonomous machinery governing the cancer cell inflammatory output in response to immunogenic therapies remains poorly defined. Here, we profiled the transcriptome of cancer cells responding to immunogenic or weakly immunogenic treatments. Bioinformatics-driven pathway analysis indicated that immunogenic treatments instigated a NF-κB/AP-1-inflammatory stress response, which dissociated from both cell death and UPR. This stress-induced inflammation was specifically abolished by the IRE1α-kinase inhibitor KIRA6. Supernatants from immunogenic chemotherapy and KIRA6 co-treated cancer cells were deprived of proinflammatory/chemoattractant factors and failed to mobilize neutrophils and induce dendritic cell maturation. Furthermore, KIRA6 significantly reduced the in vivo vaccination potential of dying cancer cells responding to immunogenic chemotherapy. Mechanistically, we found that the anti-inflammatory effect of KIRA6 was still effective in IRE1α-deficient cells, indicating a hitherto unknown off-target effector of this IRE1α-kinase inhibitor. Generation of a KIRA6-clickable photoaffinity probe, mass spectrometry, and co-immunoprecipitation analysis identified cytosolic HSP60 as a KIRA6 off-target in the IKK-driven NF-κB pathway. In sum, our study unravels that HSP60 is a KIRA6-inhibitable upstream regulator of the NF-κB/AP-1-inflammatory stress responses evoked by immunogenic treatments. It also urges caution when interpreting the anti-inflammatory action of IRE1α chemical inhibitors.
Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures
Authors: Filippa Manuela , Monaci Maria Grazia , Spagnuolo Carmen , Serravalle Paolo , Daniele Roberta , Grandjean Didier
Published: August 2021

Preterm infants undergo early separation from parents and are exposed to frequent painful clinical procedures, with resultant short- and long-term effects on their neurodevelopment. We aimed to establish whether the mother’s voice could provide an effective and safe analgesia for preterm infants and whether endogenous oxytocin (OXT) could be linked to pain modulation. Twenty preterm infants were exposed to three conditions—mother’s live voice (speaking or singing) and standard care—in random order during a painful procedure. OXT levels (pg/mL) in saliva and plasma cortisol levels were quantified, and the Premature Infant Pain Profile (PIPP) was blindly coded by trained psychologists. During the mother’s live voice, PIPP scores significantly decreased, with a concomitant increase in OXT levels over baseline. The effect on pain perception was marginally significant for singing. No effects on cortisol levels were found. The mother’s live voice modulated preterm infants’ pain indicators. Endogenous OXT released during vocal contact is a promising protective mechanism during early painful interventions in at-risk populations.