bluuebunny/crossref_metadata_2025 huggingface dataset:
Rehabilitation exoskeleton torque control based on PSO-RBFNN optimization
Authors: Li Jiayi , Tai Yuanzheng , Meng Fanwei
Published: August 2023

Exoskeletons are widely used in the field of medical rehabilitation, however imprecise exoskeleton control may lead to accidents during patient rehabilitation, so improving the control performance of exoskeletons has become crucial. Nevertheless, improving the control performance of exoskeletons is extremely difficult, the nonlinear nature of the exoskeleton model makes control particularly difficult, and external interference when the patient wears an exoskeleton can also affect the control effect. In order to solve the above problems, a method based on particle swarm optimization (PSO) and RBF neural network to optimize exoskeleton torque control is proposed to study the motion trajectory of nonlinear exoskeleton joints in this paper, and it is found that exoskeleton torque control optimized by PSO-RBFNN has faster control speed, better stability, more accurate control results and stronger anti-interference, and the optimized exoskeleton can effectively solve the problem of difficult control of nonlinear exoskeleton and the interference problem when the patient wears the exoskeleton.
Intrusive social support among Black and White individuals with type 2 diabetes: A “Control issue” or a sign of “Concern and love”?
Authors: Naqvi Jeanean B. , Liu Rachael S. , Helgeson Vicki S. , Hamm Megan E.
Published: August 2023

Family members and friends play an important supportive role in the management of chronic illnesses like diabetes, which often require substantial lifestyle changes. Some studies suggest that there may be racial differences in the kinds of support people receive, though little research has examined this idea within a chronic illness context. The current research takes a qualitative approach to examining similarities and differences between Black and White individuals with type 2 diabetes in the dimensions of support received from their family members, with a particular focus on better understanding more intrusive forms of support, such as unsolicited and overprotective support. Semi-structured interviews were conducted (N = 32) to characterize differences in support received by Black and White individuals with type 2 diabetes. The results of the thematic analysis suggested that unsolicited and overprotective support were not universally perceived to be negative, as previous work on White populations seemed to suggest. Rather, if the support provided was perceived as inhibiting autonomy, it was generally undesired by participants from both racial groups—however, for Black participants, knowing that the support was provided out of love could make it more acceptable. The analysis also revealed several underexplored dimensions of received support, including the directiveness of support and the tone used to deliver support. The current study provides an initial step towards grounding social support theory in the experiences of marginalized populations and will inform further development of a culturally sensitive measure of social support for individuals with chronic illness.
The added value of haemoglobin to height, age, and sex to predict DLCO in subjects with preserved exercise capacity
Authors: Priel Eldar , Diab Nermin , Patel Matthew , Wahab Mustafaa , Freitag Andreas , O’Byrne Paul M. , Killian Kieran J. , Satia Imran
Published: August 2023

Background

The single breath diffusion capacity for carbon monoxide (DLCO) captures several aspects of the role of the lung in meeting the metabolic demands of the body. The magnitude of the independent contributors to the DLCO is unknown. The aim of this study was to investigate the factors that independently contribute to the DLCO.

Objectives

The objective was to investigate the impact of height, age, sex and haemoglobin on DLCO, alveolar volume (VA) and carbon monoxide transfer coefficient (KCO).

Methods

Study participants were pre-screened based on normal exercise capacity achieved during an incremental cardio-pulmonary exercise testing (CPET) using cycle ergometry at McMaster University Medical Center between 1988–2012. Participants who had an FEV1>80% predicted, with an FEV1/FVC ≥0.7 and who achieved a maximum power output ≥80% were selected for analysis. In total, 16,298 subjects [61% male, mean height 1.70m (range 1.26–2.07), age 49 yrs (10–94), weight 79 kg (23–190) had DLCO measured while demonstrating normal spirometry and exercise capacity.

Results

The DLCO increased exponentially with height, was 15% greater in males, increased with age yearly until 20, then decreased yearly after the age of 35, and was 6% higher per gram of haemoglobin (5.58*Height(m)1.69*1.15 in Males*(1–0.006*Age>35)*(1+0.01*Age<20) *(1+0.06*Hb gm/dl), (r = 0.76).

Conclusion

Height, age, sex, and haemoglobin all have independent influence on the DLCO in subjects with normal spirometry and preserved exercise capacity.
Compostos de Morinda citrifolia como indutores de respostas bioquímicas em plantas de melão.
Authors: Dias Bruna Letícias , Dalcin Mateus Sunti , Costa Priscila Fonseca da , Santos Patrícia Resplandes Rocha dos , Sousa Rosangela Ribeiro de , Dias Felipe Rocha , Mourão Dalmarcia de Souza Carlos , Santos Gil Rodrigues dos
Published: August 2023

As plantas apresentam mecanismos complexos de defesa estrutural e bioquímica que podem ser ativados antes ou após o ataque de microrganismos fitopatogênicos. Dentre esses mecanismos, estão as proteínas relacionadas à patogênese (PRP) e a resposta hipersensível através da produção de espécies reativas de oxigênio (ERO), as quais auxiliam na defesa contra os fitopatógenos e redução da toxicidade dos radicais livres. A ativação deste sistema pode ser por fatores bióticos ou  abióticos que podem estimular a atividade bioquímica, denominadas substâncias elicitoras, como óleos essenciais e seus constituintes. Estudos na área são necessários para aprofundar conhecimento e atingir a viabilidade técnica e econômica de seu uso em benefício da agricultura sustentável. Objetivou-se avaliar a atividade enzimática de plantas de meloeiro submetidas à aplicação de óleo essencial de noni (OE) e ácido octanóico (AO). Foram testadas diferentes concentrações dos tratamentos e como testemunhas: fungicida Cerconil® (0,2%) e  estimulante vegetal Yantra®. As enzimas com atividade avaliada foram superóxido dismutase (SOD), quitinase (QUIT), ascorbato peroxidase (APX) e catalase (CAT). O ácido octanóico (0,1%) e óleo essencial (0,5%) foram os maiores ativadores da SOD dentre os tratamentos testados. A APX teve sua produção aumentada pela aplicação de ácido octanóico à 0,1%. O OE foi o maior ativador da CAT na concentração de 2%. Confirmando a atividade dos metabólitos secundários de Morinda citrifolia como ativadores do sistema de defesa e provável ação imediata contra microrganismos. Considerando assim compostos potenciais para o desenvolvimento de um bioproduto como substituto de defensivos agrícolas.

 

Palavras-chave: bioprodutos, compostos naturais, Cucumis melo L., espécies reativas de oxigênio, óleo essencial.
Growth of pecan rootstocks with the use of liquid humus in an organic production system
Authors: Ferreira da Silva Guilherme , Geremias Hellwig Cristiano , Farias Barreto Caroline , Martins Carlos Roberto , Mello-Farias Paulo
Published: August 2023

Pecan farming is a long-term investment which needs quality seedlings to establish an orchard. Pecan rootstocksmust have a vigorous radicular system to form quality seedlings. Liquid humus, which acts as an agent thatpromotes their growth and development, is a bioinput that is specially used in organic production systems.This study aimed at evaluating effects of different frequencies of liquid humus application on pecan rootstockgrowth and development in an organic system. Liquid humus at 30% was applied every 7, 14, 21 and 28 days.The control treatment consisted of water application. The experiment was carried out with ‘Barton’ rootstocksin a greenhouse at the Embrapa Clima Temperado located in Pelotas, RS, Brazil. The following variables wereevaluated 280 and 480 days after transplantation: plant height; stem diameter; leaf area; fresh and dry massesof the aerial part; main and secondary root lengths; fresh and dry masses of roots; fresh and dry masses of themain root; fresh and dry masses of secondary roots; and the Dickson Quality Index. Liquid humus increasedsecondary root length of pecan rootstocks, mainly when it was applied every seven days. Thus, the bioinputmay be used for this purpose.
Huellas biográficas de educadoras de párvulos en su formación inicial docente: Narrativas de la construcción de la identidad profesional
Authors: Figueroa-Céspedes Ignacio , Guerra Paula
Published: August 2023

El presente artículo tiene como propósito abordar el proceso de construcción identitaria de ocho educadoras de párvulos experimentadas de Chile, analizando aquellas huellas biográficas constitutivas de su experiencia en la formación inicial docente (FID). El método es cualitativo, de alcance descriptivo-interpretativo y con una orientación biográfico-narrativa, desarrollado a partir de entrevistas semiestructuradas, líneas de tiempo y biogramas. Se desarrolla un análisis temático en el que se agruparon aquellas huellas biográficas valorizadas por las educadoras y se concluye que las huellas están principalmente asociadas a experiencias de la formación práctica, a experiencias personales y experiencias universitarias. Se resalta la necesidad de incorporar en la FID una perspectiva de construcción identitaria, tanto en las prácticas como en el resto de las asignaturas, articulando los aspectos subjetivos y objetivos del quehacer docente en la educación parvularia.
Organization of Cultural and Leisure Activities of Students in Higher Education Institutions
Authors: Tarkivska-Nahynaliuk Olena , Opalchuk Bogdan , Iievliev Oleksandr , Soloviova Larysa , Kalinska Oksana
Published: August 2023

The article explores how the leisure culture of young individuals differs from other age groups due to their unique needs and socio-psychological characteristics. It emphasizes the importance of leisure research in understanding and catering to the youth's self-discovery and self-expression. The article proposes modernizing regulations in educational institutions to create an environment that caters to the socio-cultural and intellectual needs of today's youth. It advocates for expanding the responsibilities of children's and youth associations and involving them in sports and collaborations with employers. It suggests the establishment of a youth innovation center to nurture scientific and creative projects.The article discusses the advancements in pedagogical research and development and the role of information and communication technologies in higher education. It evaluates the effectiveness of their implementation and addresses challenges faced by the educational system. The study utilizes various research methods to identify theoretical aspects and practical considerations related to integrating technology for enhancing English-language communicative competence in higher education.The article highlights the need for continuous innovation and revitalization in leisure and education to better serve the unique characteristics and requirements of today's youth.
O Impacto do Resultado da Avaliação na Dimensão Sócio Afetiva do Estudante, a Partir das Histórias em Quadrinhos de Chico Bento
Authors: Fagundes Fabiula Falcão , Weschenfelder Gelson
Published: August 2023

A pesquisa teórica, do tipo bibliográfico, apresentando como problema de investigação: Quais são os conteúdos difundidos nas histórias em quadrinhos Chico Bento em relação ao impacto da avaliação na dimensão sócia afetiva do estudante? O corpus investigativo está composto por quatro tirinhas da Revista Chico Bento, disponibilizadas no Aplicativo Banca da Mônica, utilizado para os dispositivos móveis (smartphone). Os dados serão analisados por meio da Técnica de Análise de Conteúdo, proposta por Bardin (2016), e complementando com a análise semiológica (das imagens) para a validação do estudo, segundo Penn (2013). Ao eleger como objeto analítico os conteúdos sobre avaliação transmitidos pelas Histórias em Quadrinhos, tem-se presente de que tais histórias são formadoras de opinião e podem influenciar as concepções das crianças leitoras, corroborando ou refutando o que as mesmas entendem e vivenciam nos processos de avaliação no contexto escolar. Os resultados demonstram como a avaliação da aprendizagem aplicada de forma equivocada causa impacto na dimensão sócio afetiva do estudante. O referencial teórico do estudo está alicerçado nos pressupostos sobre avaliação de autores tais como Hoffmann (1995), Esteban (2009), Demo (2006), Vasconcellos (2008), Luckesi (2010) e Moretto (2010). Com relação às Histórias em Quadrinhos, buscamos aportes nos pressupostos de Moya (1977) e Weschenfelder (2011). Vinculado aos grupos de pesquisa Práticas Educativas e Indicadores de Qualidade, e o segundo, Universos Paralelos: Arte Sequencial, Mediação Cultural e Práticas Pedagógicas. Ambos pertencentes ao Programa de Pós-graduação da Universidade La Salle.
Adaptação Acadêmica em Universitários
Authors: Souza Andressa , Murgo Camélia Santina
Published: August 2023

O objetivo deste estudo foi realizar uma revisão integrativa da literatura sobre a adaptação acadêmica em universitários no contexto nacional no período de 2010 a 2020. Com base na metodologia PRISMA-ScR a revisão foi realizada e foram utilizados os seguintes descritores separadamente: “Adaptação Acadêmica” e “Adaptação ao Ensino Superior” em quatro bases de dados, a saber, Biblioteca Virtual em Saúde (BVS-Saúde), Scientific Electronic Library Online (SciELO), Banco Digital de Teses e Dissertações (BDTD) e Portal de Periódico da CAPES. Foram selecionadas 29 publicações distribuídas em 75,86% artigos, 20,69% dissertações e 3,45% teses. Os principais objetivos abordados nas publicações foram elencados em quatro categorias: Expectativas dos universitários frente à inserção no ambiente acadêmico, Variáveis psicossociais de interferência à adaptação acadêmica, Habilidades sociais e cognitivas, Dificuldades de adaptação e Evasão no Ensino Superior. Os resultados revelam que a adaptação acadêmica é preditora de desempenho acadêmico, saúde física e mental e da evasão dos estudantes. Ações interventivas com universitário devem ser desenvolvidas e aplicadas visto que podem gerar resultados satisfatórios no desempenho acadêmico, à qualidade de vida e à satisfação com o contexto universitário.
Czech Teachers’ Attitudes Towards LGBT+ Students
Authors: Smetáčková Irena , Simons Jack D. , Pavlík Petr
Published: August 2023

Many studies report that sexual and gender minority youth face homonegativity at school. Today schools are expected to uphold the principle of inclusive education for all students, including LGBT+ students. It is well established that LGBT+ students often encounter negative experiences. This has negative eff ects on their well-being and cognitive learning. Teachers, therefore, should support LGBT+ students. Th is study presents findings from a survey taken by 548 teachers in Czech lower secondary and higher secondary schools. The teachers described the climates intheir schools, responded to statements about educational requirements, and evaluated three school case scenarios. Most of the teachers indicated that respect and the safety of all students, including LGBT+ students, are paramount. However, attitudes toward sexual and gender minorities werefound to vary among the teachers. As a result, it appears that more training about sexuality and gender topics in Czech schools is warranted.
Task: An Efficient Framework for Instant Error-Tolerant Spatial Keyword Queries on Road Networks
Authors: Luo Chengyang , Liu Qing , Gao Yunjun , Chen Lu , Wei Ziheng , Ge Congcong
Published: August 2023

Instant spatial keyword queries return the results as soon as users type in some characters instead of a complete keyword, which allow users to query the geo-textual data in a
type-as-you-search
manner. However, the existing methods of instant spatial keyword queries suffer from several limitations. For example, the existing methods do not consider the typographical errors of input keywords, and cannot be applied to the road networks. To overcome these limitations, in this paper, we propose a new query type, i.e., instant error-tolerant spatial keyword queries on road networks. To answer the queries efficiently, we present a framework, termed as Task, which consists of index component, query component, and update component. In the index component, we design a novel index called reverse 2-hop label based trie, which seamlessly integrates spatial and textual information for each vertex of the road network. Based on our proposed index, we devise efficient algorithms to progressively return and update the query results in the query component and update component, respectively. Finally, we conduct extensive experiments on real-world road networks to evaluate the performance of our presented Task. Empirical results show that our proposed index and algorithms are up to 1--2 orders of magnitude faster than the baseline.
Autonomously Computable Information Extraction
Authors: Kassaie Besat , Tompa Frank Wm.
Published: August 2023

Most optimization techniques deployed in information extraction systems assume that source documents are static. Instead, extracted relations can be considered to be materialized views defined by a language built on regular expressions. Using this perspective, we can provide an efficient verifier (using static analysis) that can be used to avoid the high cost of re-extracting information after an update. In particular, we propose an efficient mechanism to identify updates for which we can autonomously compute an extracted relation. We present experimental results that support the feasibility and practicality of this mechanism in real world extraction systems.
CommunityAF: An Example-Based Community Search Method via Autoregressive Flow
Authors: Chen Jiazun , Xia Yikuan , Gao Jun
Published: August 2023

Example-based community search utilizes hidden patterns of given examples rather than explicit rules, reducing users' burden and enhancing flexibility. However, existing works face challenges such as low scalability, high training cost, and improper termination during the search. Aiming at tackling all these issues, this paper proposes a community search framework named CommunityAF with three well-designed components. The first is a GNN (graph neural network) component that combines community-aware structure features to incrementally learn node embeddings over a large graph for the other two components. The second is an autoregres-sive flow-based generation component designed for fast training and model stability. The third is a scoring component that evaluates the communities and provides scores for a stable termination. Moreover, to show that CommunityAF has the sufficient expressive power to cover the rules, we demonstrate that the scoring component with node features weighted by degree-related factors is able to mimic the existing structure-based community metrics. We introduce a square ranking loss to guide the training of the scoring component, and further devise a flexible termination strategy based on the inferred score change pattern over a sequence of candidate communities using beam search. We compare CommunityAF with four different categories of community search methods on six real-world datasets. The results illustrate that CommunityAF outperforms these community search methods, and achieves an average 15.3% improvement in effectiveness and 4x to 20x speedups on different datasets relative to the state-of-the-art generative method.
Trajectory Data Collection with Local Differential Privacy
Authors: Zhang Yuemin , Ye Qingqing , Chen Rui , Hu Haibo , Han Qilong
Published: August 2023

Trajectory data collection is a common task with many applications in our daily lives. Analyzing trajectory data enables service providers to enhance their services, which ultimately benefits users. However, directly collecting trajectory data may give rise to privacy-related issues that cannot be ignored. Local differential privacy (LDP), as the
de facto
privacy protection standard in a decentralized setting, enables users to perturb their trajectories locally and provides a provable privacy guarantee. Existing approaches to private trajectory data collection in a local setting typically use relaxed versions of LDP, which cannot provide a strict privacy guarantee, or require some external knowledge that is impractical to obtain and update in a timely manner. To tackle these problems, we propose a novel trajectory perturbation mechanism that relies solely on an underlying location set and satisfies pure ε-LDP to provide a stringent privacy guarantee. In the proposed mechanism, each point's adjacent direction information in the trajectory is used in its perturbation process. Such information serves as an effective clue to connect neighboring points and can be used to restrict the possible region of a perturbed point in order to enhance utility. To the best of our knowledge, our study is the first to use direction information for trajectory perturbation under LDP. Furthermore, based on this mechanism, we present an anchor-based method that adaptively restricts the region of each perturbed trajectory, thereby significantly boosting performance without violating the privacy constraint. Extensive experiments on both real-world and synthetic datasets demonstrate the effectiveness of the proposed mechanisms.
Cornet: Learning Table Formatting Rules By Example
Authors: Singh Mukul , Sánchez José Cambronero , Gulwani Sumit , Le Vu , Negreanu Carina , Raza Mohammad , Verbruggen Gust
Published: August 2023

Spreadsheets are widely used for table manipulation and presentation. Stylistic formatting of these tables is an important property for presentation and analysis. As a result, popular spreadsheet software, such as Excel, supports automatically formatting tables based on rules. Unfortunately, writing such formatting rules can be challenging for users as it requires knowledge of the underlying rule language and data logic. We present Cornet, a system that tackles the novel problem of automatically learning such formatting rules from user-provided formatted cells. Cornet takes inspiration from advances in inductive programming and combines symbolic rule enumeration with a neural ranker to learn conditional formatting rules. To motivate and evaluate our approach, we extracted tables with over 450K unique formatting rules from a corpus of over 1.8M real worksheets. Since we are the first to introduce the task of automatically learning conditional formatting rules, we compare Cornet to a wide range of symbolic and neural baselines adapted from related domains. Our results show that Cornet accurately learns rules across varying setups. Additionally, we show that in some cases Cornet can find rules that are shorter than those written by users and can also discover rules in spreadsheets that users have manually formatted. Furthermore, we present two case studies investigating the generality of our approach by extending Cornet to related data tasks (e.g., filtering) and generalizing to conditional formatting over multiple columns.
ARKGraph: All-Range Approximate K-Nearest-Neighbor Graph
Authors: Zuo Chaoji , Deng Dong
Published: August 2023

Given a collection of vectors, the approximate K-nearest-neighbor graph (KGraph for short) connects every vector to its approximate K-nearest-neighbors (KNN for short). KGraph plays an important role in high dimensional data visualization, semantic search, manifold learning, and machine learning. The vectors are typically vector representations of real-world objects (e.g., images and documents), which often come with a few structured attributes, such as times-tamps and locations. In this paper, we study the all-range approximate K-nearest-neighbor graph (ARKGraph) problem. Specifically, given a collection of vectors, each associated with a numerical search key (e.g., a timestamp), we aim to build an index that takes a search key range as the query and returns the KGraph of vectors whose search keys are within the query range. ARKGraph can facilitate interactive high dimensional data visualization, data mining, etc. A key challenge of this problem is the huge index size. This is because, given
n
vectors, a brute-force index stores a KGraph for every search key range, which results in
O
(K
n
3
) index size as there are
O
(
n
2
) search key ranges and each KGraph takes
O
(K
n
) space. We observe that the KNN of a vector in nearby ranges are often the same, which can be grouped together to save space. Based on this observation, we propose a series of novel techniques that reduce the index size significantly to just
O
(K
n
log
n
) in the average case. Furthermore, we develop an efficient indexing algorithm that constructs the optimized ARKGraph index directly without exhaustively calculating the distance between every pair of vectors. To process a query, for each vector in the query range, we only need
O
(log log
n
+ K log K) to restore its KNN in the query range from the optimized ARKGraph index. We conducted extensive experiments on real-world datasets. Experimental results show that our optimized ARKGraph index achieved a small index size, low query latency, and good scalability. Specifically, our approach was 1000x faster than the baseline method that builds a KGraph for all the vectors in the query range on-the-fly.
Causal Data Integration
Authors: Youngmann Brit , Cafarella Michael , Salimi Babak , Zeng Anna
Published: August 2023

Causal inference is fundamental to empirical scientific discoveries in natural and social sciences; however, in the process of conducting causal inference, data management problems can lead to false discoveries. Two such problems are (i) not having all attributes required for analysis, and (ii) misidentifying which attributes are to be included in the analysis. Analysts often only have access to partial data, and they critically rely on (often unavailable or incomplete) domain knowledge to identify attributes to include for analysis, which is often given in the form of a causal DAG. We argue that data management techniques can surmount both of these challenges. In this work, we introduce the Causal Data Integration (CDI) problem, in which unobserved attributes are mined from external sources and a corresponding causal DAG is automatically built. We identify key challenges and research opportunities in designing a CDI system, and present a system architecture for solving the CDI problem. Our preliminary experimental results demonstrate that solving CDI is achievable and pave the way for future research.
Effects of photobiomodulation and caffeine treatment on acute kidney injury in a hypoxic ischemic neonatal rat model
Authors: Groves A. M. , Johnston C. J. , Beutner G. , Dahlstrom J. E. , Koina M. , O'Reilly M. , Marples B. , Porter G. , Brophy P. D. , Kent A. L.
Published: August 2023

Hypoxic ischemic encephalopathy (HIE) occurs in 2–5/1000 births, with acute kidney injury (AKI) occurring in 40%. AKI increases morbidity and mortality. Caffeine, an adenosine receptor antagonist, and photobiomodulation (PBM), working on cytochrome c oxidase, are potential treatments for AKI. To examine effects of caffeine and PBM on AKI in rats, Day 7 pups underwent a HIE intervention (Modified Rice–Vannucci model) replicating pathology observed in humans. Caffeine was administered for 3 days and/or PBM for 5 days following HIE. Weights and urine for biomarkers (NGAL, albumin, KIM‐1, osteopontin) were collected prior to HIE, daily post intervention and at sacrifice. Both treatments reduced kidney injury seen on electron microscopy, but not when combined. HIE elevated urinary NGAL and albumin on Days 1–3 post‐HIE, before returning to control levels. This elevation was significantly reduced by PBM or caffeine. KIM‐1 was significantly elevated for 7 days post‐HIE and was reduced by both treatments. Osteopontin was not altered by HIE or the treatments. Treatments, individually but not in combination, improved HIE‐induced reductions in the enzymatic activity of mitochondrial complexes II‐III. PBM and caffeine also improved weight gain. PBM and caffeine reduces AKI diagnosed by urinary biomarkers and confirmed by EM findings.
Cold water immersion in recovery following a single bout resistance exercise suppresses mechanisms of miRNA nuclear export and maturation
Authors: D'Souza Randall F. , Figueiredo Vandre C. , Markworth James F. , Zeng Nina , Hedges Christopher P. , Roberts Llion A. , Raastad Truls , Coombes Jeff S. , Peake Jonathan M. , Mitchell Cameron J. , Cameron‐Smith David
Published: August 2023

Cold water immersion (CWI) following intense exercise is a common athletic recovery practice. However, CWI impacts muscle adaptations to exercise training, with attenuated muscle hypertrophy and increased angiogenesis. Tissue temperature modulates the abundance of specific miRNA species and thus CWI may affect muscle adaptations via modulating miRNA expression following a bout of exercise. The current study focused on the regulatory mechanisms involved in cleavage and nuclear export of mature miRNA, including DROSHA, EXPORTIN‐5, and DICER. Muscle biopsies were obtained from the vastus lateralis of young males (n = 9) at rest and at 2, 4, and 48 h of recovery from an acute bout of resistance exercise, followed by either 10 min of active recovery (ACT) at ambient temperature or CWI at 10°C. The abundance of key miRNA species in the regulation of intracellular anabolic signaling (miR‐1 and miR‐133a) and angiogenesis (miR‐15a and miR‐126) were measured, along with several gene targets implicated in satellite cell dynamics (NCAM and PAX7) and angiogenesis (VEGF and SPRED‐1). When compared to ACT, CWI suppressed mRNA expression of DROSHA (24 h p = 0.025 and 48 h p = 0.017), EXPORTIN‐5 (24 h p = 0.008), and DICER (24 h p = 0.0034). Of the analyzed miRNA species, miR‐133a (24 h p < 0.001 and 48 h p = 0.007) and miR‐126 (24 h p < 0.001 and 48 h p < 0.001) remained elevated at 24 h post‐exercise in the CWI trial only. Potential gene targets of these miRNA, however, did not differ between trials. CWI may therefore impact miRNA abundance in skeletal muscle, although the precise physiological relevance needs further investigation.
AlgDiff: an open source toolbox for the design, analysis and discretisation of algebraic differentiators
Authors: Othmane Amine , Rudolph Joachim
Published: August 2023

Algebraic differentiators have attracted much interest in recent years. Their simple implementation as classical finite impulse response digital filters and systematic tuning guidelines may help to solve challenging problems, including, but not limited to, nonlinear feedback control, model-free control, and fault diagnosis. This contribution introduces the open source toolbox AlgDiff for the design, analysis and discretisation of algebraic differentiators.
Einbettungsbeobachter für polynomiale Systeme
Authors: Gerbet Daniel , Röbenack Klaus
Published: August 2023

In vielen Anwendungen der Regelungstechnik werden Beobachter eingesetzt, um interne Zustandsgrößen oder Parameter zu schätzen oder Fehler zu detektieren. Solche Beobachter lassen sich auch für nichtlineare Systeme systematisch auf Basis der Beobachter- oder der Beobachtbarkeitsnormalform entwerfen. Letztere existiert für eine größere Systemklasse. Allerdings ist das Vektorfeld in der Beobachtbarkeitsnormalform nicht unbedingt an allen Punkten definiert oder Lipschitz-stetig, selbst wenn diese Eigenschaften auf die ursprüngliche Systemdarstellung zutreffen. Durch die Einbettung in höherdimensionale Räume ist es möglich, die Normalform einerseits zu konstruieren und gegebenenfalls gewisse singuläre Punkte zu vermeiden. In diesem Beitrag wird gezeigt, wie dies systematisch für polynomiale Systeme mit mehreren Ein- oder Ausgängen bewerkstelligt werden kann.
Passive nonreciprocal transmission and optical bistability based on polarization-independent bound states in the continuum
Authors: Chen Shiwen , Zeng Yixuan , Li Zhongfu , Mao Yu , Dai Xiaoyu , Xiang Yuanjiang
Published: August 2023

Free-space nonreciprocal transmission is a crucial aspect of modern optics devices. The implementation of nonreciprocal optical devices through optical nonlinearity has been demonstrated. However, due to the weak nonlinearity of traditional materials, most self-biased nonreciprocal devices are heavily dependent on the high Q strong resonances. In general, these resonances are frequently polarization sensitive. In this work, we propose ultrathin optical metasurface embedding Kerr nonlinearities to achieve nonreciprocal transmission and optical bistability for free-space propagation based on symmetry-protected bound states in the continuum (BICs). Since the structure of the metasurface retains C4ν symmetry, the symmetry-protected BIC is polarization-independent. It is also shown that the nonreciprocal intensity range could be largely tuned by the structure parameters. The demonstrated devices merge the field of nonreciprocity with ultrathin metasurface technologies making this design an exciting prospect for an optical switch, routing, and isolator with optimal performance.
Two-photon interference from silicon-vacancy centers in remote nanodiamonds
Authors: Waltrich Richard , Klotz Marco , Agafonov Viatcheslav N. , Kubanek Alexander
Published: August 2023

The generation of indistinguishable photons is a key requirement for solid-state quantum emitters as a viable source for applications in quantum technologies. Restricting the dimensions of the solid-state host to a size well below the wavelength of light emitted by a defect-center enables efficient external optical coupling, for example, for hybrid integration into photonic devices. However, stringent restrictions on the host dimensions result in severe limitations on the spectral properties reducing the indistinguishability of emitted photons. Here, we demonstrate two-photon interference from two negatively charged silicon-vacancy centers located in remote nanodiamonds. The Hong–Ou–Mandel interference efficiency reaches 61 % with a coalescence time window of 0.35 ns. We furthermore show a high yield of pairs of silicon-vacancy centers with indistinguishable optical transitions. Therefore, our work opens new paths in hybrid quantum technology based on indistinguishable single-photon emitters in nanodiamonds.
The crystal structure of diaqua-(naphthalene-4,5-dicarboxylate-1,8-dicarboxylic anhydride-κ1O)-(4′-(4-(1H-benzimidazolyl-1-yl)phenyl)-2,2′:6′,2″-terpyridine-κ
3
N,N′,N″)–manganese(II) dihydrate, C42H27MnN5O9·2H2O
Authors: Liu Xinyao , Liu Qianyu , Xiao Leijie , Fu Weiwei
Published: August 2023

C42H27MnN5O9·2H2O, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 12.4250(8) Å, b = 12.7259(8) Å, c = 14.2946(9) Å, α = 64.102(2)°, β = 79.774(2)°, γ = 62.453(2)°, V = 1801.9(2) Å3, Z = 2, R
gt(F) = 0.0344, wR
ref(F
2) = 0.0951, T = 150 K.
Introduction: The Global 1970s from a History of Emotions Perspective
Authors: Barua Rukmini , Moine Caroline , Oberländer Alexandra , Wambach Julia
Published: August 2023

The 1970s have been identified through a range of emotional markers. This special issue critically analyzes the emotional history of this decade through a global perspective. In doing so, the contributions in this issue consider the different registers and scales at which emotions were experienced, perceived, and discussed. Drawing on discussions of gay liberation struggles in Latin America, decolonial movements in Palestine, the New International Economic Order, the North American Left, and forms of post-imperialist belonging in New Zealand and Australia, we detail how new emotional communities were produced and how distinct emotionalities were shaped in conjunction with shifting global politics.
Study on properties of paper coated with Stachys floridana Shuttlew. ex Benth hemicellulose – chitosan composite solution
Authors: Li Jie , Liu Haitang , Wang Qian , Wang Yefan , Chen Lin , Jin Xin , Guo Zhihua , Wang Ting , Zhang Xinyu
Published: August 2023

The hemicellulose was extracted from the Stachys floridana Shuttlew. ex Benth by ultrasonic-assisted, fractional alcohol precipitation method, mixed with chitosan solution, and coated on the surface of the paper with three layers, to explore the effect of its morphology, thermal stability, barrier, mechanical properties of coated paper. The results showed that the gas barrier property of the paper coated with hemicellulose – chitosan mixed solution decreased from 180 mL/min to 0.265 mL/min, the water barrier property increased from 0 to 84.8°, and the oil barrier property increased from 0 to Kit nº11. The tearing degree of paper increased by 9.2 %, the folding resistance increased by 1296.6 %, dry and wet tensile strength and dry and wet rupture resistance were also significantly improved. The thermal stability mixed solution coated paper is slightly lower than the base paper, but higher than the pure chitosan coated paper. The prepared S. floridana Shuttlew. ex Benth hemicellulose – chitosan blend coating has good barrier property and mechanical properties, and has a wide application prospect.
Clinical importance of PCA3 lncRNA aberrant expression in chronic myeloid leukemia patients: a comparative method
Authors: He Ling , Zhang Jie , Peng Yang , Wu Hongwei , Sun Zhiqiang
Published: August 2023

Objectives

Long noncoding RNAs (lncRNAs) plays important role in disease spread and its invasion. Overexpression of prostate cancer antigen 3 gene (PCA3gene) is reported in prostate cancer. To analyze the PCA3 lncRNA expression in chronic myeloid leukemia (CML) patients.

Methods

The study included clinically confirmed 100 CML patients and 100 healthy subjects. Relative quantification using Sybr Green dye was used to calculate the PCA3 lncRNAs expression. Total RNA was extracted by TRIzol method and quantitative real-time polymerase chain reaction.

Results

In CML patients, 9.96 ± 4.77-folds increased noncoding PCA3 lncRNA expression was observed compared to healthy subjects. Patients of chronic phase, accelerated phase, and blast crisis phase had 4.46 ± 1.36, 7.31 ± 3.10, and 12.91 ± 4.85-fold PCA3 lncRNA expression compared to healthy subjects (p<0.0001), respectively. CML patients who have a complaint of splenomegaly had higher PCA3 lncRNA expression than those who did not complain splenomegaly compared to healthy subjects (12.04 ± 5.02-fold vs. 6.09 ± 3.39-fold, p<0.0001). Patients who had ≤20,000 TLC showed fewer PCA3 lncRNA expression than those who had >20 thousand of TLC (4.45 ± 1.84 vs. 11.25 ± 5.05, p<0.0001). Receiver operating characteristic showed correlation of PCA3 lncRNA expression with severity of cancer.

Conclusions

lncRNA PCA3 expression to be linked with different stages of the disease and a prognostic indicator for disease in CML patients.
¿Nueva Izquierda o nueva ortodoxia? Laurette Séjourné y la Revolución cubana en 1970
Authors: Urías Horcasitas Beatriz
Published: August 2023

Este artículo examina los enfrentamientos generados por la Revolución cubana en la izquierda intelectual mexicana al inicio de 1970. La correspondencia de Laurette Séjourné, arqueóloga de origen italiano radicada en México, permite identificar las tensiones que se produjeron entre quienes mantuvieron una lealtad incondicional hacia el régimen cubano y aquellos que pusieron una distancia a partir de la sovietización. Esta confrontación muestra que la Nueva Izquierda no fue un grupo ideológicamente homogéneo e invita a problematizar el uso de esta categoría.
Spleen‐targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma
Authors: Wu Ming , Luo Zijin , Cai Zhixiong , Mao Qianqian , Li Zhenli , Li Hao , Zhang Cao , Zhang Yuting , Zhong Aoxue , Wu Liming , Liu Xiaolong
Published: August 2023

Neoantigens are emerging as attractive targets to develop personalized cancer vaccines, but their immunization efficacy is severely hampered by their restricted accessibility to lymphoid tissues where immune responses are initiated. Leveraging the capability of red blood cells (RBCs) to capture and present pathogens in peripheral blood to the antigen‐presenting cells (APCs) in spleen, we developed a RBC‐driven spleen targeting strategy to deliver DNA vaccine encoding hepatocellular carcinoma (HCC) neoantigen. The DNA vaccine‐encapsulating polymeric nanoparticles that were intentionally hitchhiked on the preisolated RBCs could preferentially accumulate in the spleen to promote the neoantigen expression by APCs, resulting in the burst of neoantigen‐specific T‐cell immunity to prevent tumorigenesis in a personalized manner, and slow down tumor growth in the established aggressively growing HCC. Remarkably, when combined with anti‐PD‐1, the vaccine achieved complete tumor regression and generated a robust systemic immune response with long‐term tumor‐specific immunological memory, which thoroughly prevented tumor recurrence and spontaneous lung metastasis. This study offers a prospective strategy to develop personalized neoantigen vaccines for augmenting cancer immunotherapy efficiency in immune “cold” HCC.
Рукапісы “Пінскае шляхты”
Authors:   Uniwersytet Warszawski, Chaustowicz Mikałaj
Published: August 2023

Vincent Dunin Marcinkievič’s Pinsk Nobility has been not only repeatedly interpreted by literary critics but also undergone historical and textual analyses. However, a number of points still remain unclear, both in regard to the interpretation of individual expressions and the manuscript’s origins, as well as the history of the text from 1866 to 1918. As is argued, it is possible to fill in some of those blind spots.
Рэцэпцыя творчасці Сакрата Яновіча ў Польшчы
Authors:   Uniwersytet w Białymstoku, Sakowicz Anna
Published: August 2023

The article focuses on the reception of the literature of the Belarusian writer living in Poland, Sokrat Janowicz. His works, like many foreign-language authors, are perceived by the Polish reader only on the basis of translations. Janowicz’s translated books do not have their equivalents in the original, they are a selection of works from the author’s volume. On the basis of the published collections, the writer was admitted to the Association of Polish Writers, and his prose was included in the canon of Polish literature. The situation in which translations show only a certain aspect of the author’s work causes problems with its reception and analysis. An example of this is including Janowicz in the so-called peasant trend. The rural reality presented in the works as the sociological living conditions of Belarusians in Poland is not the main subject of this writer’s literature. In his works, Janowicz shows the interesting inner world of a man who tries to understand his existence on the borderland of cultures. He emphasizes the importance of the native tradition, the “language of childhood”.
Migrations of the russian Language and the State Academic institutions: Notes on its cultivation and Depopularization in Georgia and its peripheries (Abkhazia and South Ossetia)
Authors:   Ruhr University, Bochum, Niemcy, Chkhaidze Elena
Published: August 2023

The history of the building, construction, and collapse of states makes it possible to observe the expansion of the Empire’s language and the changes that are taking place in the politics of language and education, including those in higher education. Georgia’s history is a telling example of this. After the Russian Empire came to power, institutions of higher education were established, which included education in Russian as well. Moreover, writing languages were also created for the ethnic groups that made up the Georgian population (Abkhaz and Ossetians) in order to widen their influence and integration into the empire. In the Soviet time, these practices became stronger. After the collapse of the USSR, linguistic priorities in education changed, and institutions in the periphery were divided into those that stayed in the old territories with the new national curriculum and those that moved under the old names to the central locations of the former Soviet republic center (the Abkhaz University in Tbilisi and in Sukhumi).
Еволюція образу провінції в австрійській літературі XX ст.
Authors:   Чернівецький національний університет ім. Юрія Федьковича, Isapchuk Yulia
Published: August 2023

The study analyses three formation phases of the Austrian literature in the20th century, which relate to the explanation of the depiction’s principles of the province. The role of the literary tradition in the understanding of the native region’s chronotope is emphasized. The attention is drawn to the change in the connotation of the Austrian regional literature (Heimatliteratur) in the context of historical, social, and aesthetic factors with the parallel modification of the region’s image: the allGerman antimodernist movement Heimatkunst and its Austrian version Provinzkunst; radicalization of the interwar period and the “Blood and Soil Literature” (Blut-und-Boden-Literatur); updating by the new movement “Anti-regional literature” (AntiHeimatliteratur). The evolution of the reception and interpretation of the province’s image as a fabula’s constant of the text is studied, including the transmission from idealization to the desacralization of the locus.
Influence of Psychosocial Characteristics on Social Media Usage among Continuing Education Learners (Cels) in Kwara State University, Malete, Nigeria
Authors: Yusuf Murtala Akanbi , Yunusa Abdullhai Abubakar , Sulaiman Kabir Alabi , Adeyemi Ismail Olatunji
Published: August 2023

In line with the growing incursion/adoption of social media into teaching and learning, this study was conducted to understand continuing education learners’ psycho-social characteristics and their influence on their social media. A quantitative research design approach using an online Google form with 388 participants was adopted. Descriptive statistics, t-test and ANOVA were used. Results revealed that the students mostly used Facebook as their major social media platform for connecting with friends and family along with WhatsApp, Twitter, and Instagram. In addition, the study revealed that learners with higher self-concept and socioeconomic status are more inclined to social media usage among CELs. It is believed that the knowledge of psychosocial characteristics of CELs on their usage of social media will inform a bespoke and purposeful curriculum planning, design and implementation that optimizes the achievement of the learning objectives for different classes of the students based on their psycho-social differences.

Abstrak

Sejalan dengan semakin maraknya penggunaan/adopsi media sosial ke dalam proses belajar mengajar, penelitian ini dilakukan untuk memahami karakteristik psiko-sosial peserta didik pendidikan lanjutan dan pengaruhnya terhadap media sosial mereka. Pendekatan desain penelitian kuantitatif menggunakan formulir Google online dengan 388 peserta diadopsi. Statistik deskriptif, uji-t dan ANOVA digunakan. Hasil penelitian menunjukkan bahwa sebagian besar siswa menggunakan Facebook sebagai platform media sosial utama mereka untuk terhubung dengan teman dan keluarga bersama dengan WhatsApp, Twitter, dan Instagram. Selain itu, penelitian ini mengungkapkan bahwa pelajar dengan konsep diri dan status sosial ekonomi yang lebih tinggi lebih cenderung menggunakan media sosial di kalangan CEL. Diyakini bahwa pengetahuan tentang karakteristik psikososial CELs dalam penggunaan media sosial mereka akan menginformasikan perencanaan, desain, dan implementasi kurikulum yang dipesan lebih dahulu dan bertujuan yang mengoptimalkan pencapaian tujuan pembelajaran untuk kelas siswa yang berbeda berdasarkan perbedaan psiko-sosial mereka.