bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel CPE procedure by oil-in-water microemulsion for preconcentrating and analyzing thorium and uranium
Authors: Jia Lipei , Li Zejun , Shi Weiqun , Shen Xinghai
Published: March 2022

A novel cloud point extraction (CPE) procedure was developed to preenrich Th4+ and UO2
2+ by oil-in-water (O/W) microemulsion. Coupling CPE to ICP-MS, the separation and analysis were achieved at a trace level, in which the low detection limits were 0.019 and 0.042 ng mL−1 for Th(IV) and U(VI), respectively. N,N′-diethyl-N,N′-ditolyl-2,9-diamide-1,10-phenanthroline (Et-Tol-DAPhen), as an extremely hydrophobic extractant, was failed to dissolve in single or mixed micelles, but was successfully solubilized to CPE system owing to O/W microemulsion. The extraction efficiency and selectivity for Th4+ and UO2
2+ were excellent under acidic condition of 1.0 mol L−1 HNO3, and the recovery of ultra-trace Th4+ and UO2
2+ was almost 100% even at the presence of large amounts of lanthanides, exhibiting high tolerance limits for lanthanides. The solubilization, extraction and coordination behaviours were studied systematically via DLS, UV–vis, 1H NMR and FT-IR. Moreover, the solubilization of N,N′-dioctyl-N,N′-dioctyl-2,9-diamide-1,10-phenanthroline (Oct-Oct-DAPhen) and efficient extraction for UO2
2+ were also realized by O/W microemulsion, which further proved the feasibility of the method.
Development and performance evaluation of a novel environmentally friendly adsorbent for waste water-based drilling fluids
Authors: Guo Yong , Nie Minghu , Wang Yingjie , Zhong Zhen , Liu Yunfeng
Published: March 2022

Adsorbent is an important waste water-based drilling fluid treatment agent, which can adsorb and settle heavy metal ions, high polymer organics, and other soluble harmful substances in the waste drilling fluid. Traditional adsorbents such as polyaluminum chloride and polyacrylamide will produce other metal ions or toxic monomers after hydrolysis, which cannot fully meet the requirements of safety and environmental protection. Therefore, a new environmentally friendly waste water-based drilling fluid adsorbent, named RH-β-CD, was prepared by the Wilson etherification reaction, which was initiated by epichlorohydrin and ceric ammonium nitrate, and successfully grafted rhamnolipid and amine strong adsorption groups onto β-cyclodextrin. The adsorption effect and environmental protection performance of RH-β-CD on the organic matter and chromium ion in waste sulfonated water-based drilling fluid were evaluated and compared with commonly used adsorbents such as activated carbon, PAM, and polyaluminum chloride. The results show that RH-β-CD can effectively adsorb the organic matter in the filtrate of waste water-based drilling fluids, reduce its chemical oxygen consumption, and reduce the concentration of heavy metal ions in the filtrate. The effect is better than PAM, activated carbon, and polyaluminum chloride, with the BOD5/CODcr >20% and EC50 >1,000,000 mg·L−1, which is environmentally friendly.
The correlation between bone biomarkers, glucosylsphingosine levels, and molecular findings in Gaucher type 1 patients under enzyme therapy
Authors: Ersoy Melike , Yegül Duygu , Pişkinpaşa Hamide , Gedikbasi Asuman
Published: March 2022

Objectives

We aimed to determine the relationship of Lyso-Gb1 levels, bone biomarkers, and mutation findings with bone marrow burden (BMB) scores.

Methods

Lyso-Gb1 and bone biomarkers, and BMB scores of 10 Gaucher type 1 (GD1) patients under enzyme therapy were prospectively evaluated.

Results

Ten GD1 patients, aged between 4.5 and 40 (mean 23 ± 11 years), were included in the study. Four patients were homozygous for L444P/L444P, and six patients were compound heterozygous for N370S/R415H. We found positive correlations between pain and BMB scores with Lyso-Gb1 levels (r=0.889, p=0.001 and r=0.701, p=0.035, respectively). There were negative correlations between bone mineral density (BMD) of both the lumbar spine and femoral neck between Lyso-Gb1 levels (r=−0.929, p=0.001 and r=−0.893, p=0.007, respectively). Patients with L444P/L444P mutation had higher Lyso-Gb1 levels and BMB, pain scores and lower BMD measurements than patients with N370S/R415H (p=0.01, p=0.02, p=0.03, p=0.04, p=0.04, respectively).

Conclusions

There was an apparent correlation between, Lyso-Gb1 levels, BMB scores and genotype in evaluating bone involvement in Gaucher patients.
Qualitative analysis of an eco-epidemiological model with a role of prey and predator harvesting
Authors: Pal Amit K. , Bhattacharyya Anindita , Mondal Ashok , Pal Srishti
Published: March 2022

The present study deals with the dynamical response of an eco-epidemiological model consisting of prey and predator species having infection in prey population. The inclusion of prey refugia is taken into account to avoid predator attack. The entire prey population is divided into two parts: healthy prey which are capable of reproducing following the logistic law and infected prey which is removed by predation or death before having the possibility of reproducing. Also we have considered the role of harvesting of the susceptible prey and the predator. For biological validity of the model, positivity and boundedness of the system are studied. The dynamical behaviour of the model has been analyzed elaborately. The stability aspects of the basic model around the infection free state, predator free state and the infected steady state from a local as well as a global perspective are studied. The main aim is to study the role of harvesting on the dynamics of disease propagation and/or eradication. By considering harvesting in susceptible prey and predator population, our study gives a new direction to eco-epidemiological model. Changes in local and global dynamical behaviour in terms of important system parameters are obtained. By the numerical simulation Hopf-bifurcation and the stable and unstable behaviour of the system due to harvesting and rate of infection have been observed.
Kartellierte internationale Märkte und innovative Produkte
Authors: Avci Meral , Henrich-Franke Christian
Published: March 2022

The Bayer AG was cut off from the quinine world trade by the quinine cartel, existing mainly of Great Britain, France and Netherlands, during the Great War. Being unable to purchase ingredients to produce malaria drug Bayer decided to develop synthetic active ingredients to treat malaria patients. This was an innovative approach to the malaria problem by Bayer’s research department accompanied with an organizational change. This paper analyzes the international cooperation of the Bayer tropical medicine department in the 1920s and 1930s with regard to the development of test fields and sales markets for the synthetic antimalarial agents. How and why did the tropical medicine research department develop into a significant international player with innovative products? How did the tension between international research cooperation and commercial exploitation change? What role did the particular political circumstances and their change play in the transformation of cooperation and the development of markets? By answering these questions, this paper demonstrates that Bayer quite successfully pursued an innovation-based strategy of market development, which aimed at convincing the international scientific community and generating international prestige. Nevertheless, the Italian demand and the specific interests of Italian malaria research – low cost domestic supply of antimalarial drugs, colonial expansionism, and international influence – were crucial door openers for the breakthrough on the international market.
Sprungbrett für den US-Markt
Authors: Kleinschmidt Christian
Published: March 2022

In the context of the internationalisation and globalisation of the economy, special economic zones are playing an increasingly important role. The economic-historical evaluation of these special economic zones is controversially discussed and fluctuates between a «neo-colonialist exploitation of the Global South» based on low wages and poor working conditions as well as the exploitation of tax havens on the one hand and the emphasis on economic development potentials in these countries on the other. Using the non-representative corporate history case study of the medical technology manufacturer Sartorius, the aim is to ask, based on the motives, expectations and decision-making processes of a company in a specific economic-historical situation between the mid-1970s and mid-1980s, what significance the special economic zone of Puerto Rico had for corporate strategy in this phase. It will be shown that the corporate development and growth of Sartorius at the Goettingen location reached its limits during this period and that alternative investment opportunities were sought, which were found primarily in the world’s largest market for its products: the US market. High customs duties and transport costs ultimately led to considerations of direct investment on the American continent, whereby the investment incentives in the US special economic zone of Puerto Rico, supported by government subsidy programmes of the Federal Republic, offered considerably more advantages than on the mainland. In the case of Sartorius, with regard to the Puerto Rico Special Economic Zone, it is less about the exploitation of «neocolonial exploitation mechanisms» in a region of the Global South than about the use of Puerto Rican as well as Federal Republic investment incentives, which also offered development potential for Puerto Rico itself.

Der Beitrag entstand im Kontext der Publikation Sartorius 1870–2020, von Hartmut Berghoff, Christian Kleinschmidt, Stephan H. Lindner, Luitgard Marshall, München 2021. Die spezifische Frage zur Rolle von Puerto Rico im Rahmen der Unternehmensstrategie Sartorius’ konnte dort nur knapp angerissen und nicht in seiner ganzen Komplexität dargestellt werden (135–137) und wird hier ausführlich und quellenbasiert diskutiert.
Business History in Europe
Authors: Astore Marianna , Binda Veronica
Published: March 2022

This article examines the working conditions of young business historians in Europe, looking at both the demand and the supply side of the junior job market. It is based on responses to a questionnaire submitted to all the participants in the European Business History Association (EBHA) Doctoral Summer School, and on a database of the positions offered in BH (or related fields) from 2016 up to 2020. The analysis brings to light several problems connected with the precariousness of the job market and the shortage of opportunities. Even so, young scholars’ job satisfaction is generally high overall, though less so in Southern Europe.
Trading costs and trading quantity at the Berlin Stock Exchange, 1892–1913
Authors: Burhop Carsten , Gelman Sergey
Published: March 2022

We estimate two components of stock market liquidity, namely trading costs and trading volume, for the Berlin Stock Exchange, 1892–1913. Our three trading cost indicators are highly correlated with each other. To estimate trading volume, we use turnover tax revenues and turnover data from the Berliner Kassenverein. We use information on stock exchange turnover taxes collected in Berlin and we have compiled monthly data. We show that the three indicators of trading volume are highly correlated.
Laboratory Accelerated Testing of Traffic Polishing Effects on Asphalt Paving Mixtures
Authors: Zhou Bo , Chu L. , Yang Lintao , Fwa T. F.
Published: March 2022

Most laboratory polishing machines for pavement materials in use today are bulky and could not be easily fabricated in a typical pavement engineering laboratory. Most machines adopt a small-diameter circular-path polishing mode, which is different from actual field polishing actions, to save space and reduce test durations. Still, each test typically lasts longer than a day. To overcome the problems of test duration and polishing mode, this study developed a high-slip ratio linear-path polishing device to achieve a test duration of less than 4 h. The main research objectives were to study the polishing effects of different polishing modes and propose a polishing procedure to produce a polished state of British pendulum number (BPN) and mean texture depth (MTD) matching with field measured values. The four polishing modes studied were 1. dry polishing, 2. wet polishing, 3. dry polishing with sand, and 4. wet polishing with sand. The presence of water was found to have no statistically significant effect on the terminal BPN and MTD. When sand was applied, whether in dry (Mode 3) or wet (Mode 4) polishing, lower terminal MTD but higher BPN than those by Mode 1 or 2 were obtained. If polishing was continued without sand, the terminal BPN became lower than that achieved by Mode 1 or 2. Upon comparing laboratory polished BPNs with polished BPNs of in-service pavements, this study recommended the following two-stage mixed-mode polishing procedure: Mode 3 or 4 polishing with sand, followed by either Mode 1 or 2 polishing without sand.
Romanian Guidelines for the Diagnosis and Treatment of GERD-induced Respiratory Manifestations
Authors: Drug Vasile Liviu , Antoniu Sabina , Oana Barboi Bogdana , Arghir Oana Cristina , Bancila Ion , Bataga Simona , Brisc Ciprian , Cijevschi-Prelipcean Cristina , Ciocîrlan Mihai , Ciortescu Irina , David Liliana , Deleanu Oana Claudia , Diculescu Mircea , Dimitriu Anca , Dobru Daniela , Dumitru Eugen , Gheonea Dan Ionut , Gheorghe Cristian , Goldis Adrian , Jinga Mariana , Man Milena , Mateescu Bogdan , Manuc Mircea , Mihai Catalina , Mihaltan Florin , Mihaescu Traian , Nedelcu Laurentiu , Negreanu Lucian , Pop Carmen Monica , Rajnoveanu Ruxandra , Saftoiu Adrian , Seicean Andrada , Sporea Ioan , Stanciu Carol , Surdea-Blaga Teodora , Tantau Marcel , Todea Doina , Trifan Anca Victorita , Ulmeanu Ruxandra , Iov Diana Elena , Dumitrascu Dan Lucian
Published: March 2022

Background and Aims: Gastroesophageal reflux disease (GERD) is a common condition present in daily practice with a wide range of clinical phenotypes. In this line, respiratory conditions may be associated with GERD. The Romanian Societies of Gastroenterology and Neurogastroenterology, in association with the Romanian Society of Pneumology, aimed to create a guideline regarding the epidemiology, diagnosis and treatment of respiratory conditions associated with GERD.Methods: Delphi methodology was used and eleven common working groups of experts were created. The experts reviewed the literature according to GRADE criteria and formulated 34 statements and recommendations. Consensus (>80% agreement) was reached for some of the statements after all participants voted.Results: All the statements and the literature review are presented in the paper, together with their correspondent grade of evidence and the voting results. Based on >80% voting agreement, a number of 22 recommendations were postulated regarding the diagnosis and treatment of GERD-induced respiratory symptoms. The experts considered that GERD may cause bronchial asthma and chronic cough in an important number of patients through micro-aspiration and vagal-mediated tracheobronchial reflex. GERD should be suspected in patients with asthma with suboptimal controlled or after exclusion of other causes, also in nocturnal refractory cough which needs gastroenterological investigations to confirm the diagnosis. Therapeutic test with double dose proton pump inhibitors (PPI) for 3 months is also useful. GERD induced respiratory conditions are difficult to treat; however,proton pump inhibitors and laparoscopic Nissen fundoplication are endorsed for therapy.Conclusions: This guideline could be useful for the multidisciplinary management of GERD with respiratory symptoms in current practice.
Pattern of hematological disorders on bone marrow examination: a tertiary care hospital experience
Authors: Fareed Noorulain , Mehmood Tariq , Quraishy M Saeed , Fatima Ghulam
Published: March 2022

ackground: Hematological disorders are quite frequent in all age group. Most of these hematological disorders first present as anemia. Bone Marrow Aspiration plays a major role in the diagnosis of it’s underlying cause. The aim of this study was to analyze the causes of hematological disorders, its spectrum and to interpret the bone marrow aspiration findings. Objective: The aim of the study is to evaluate the clinical profile, spectrum, cytological and histological pattern of various hematological disorders reported in bone marrow aspiration and trephine biopsy respectively. Study design: This was a Retrospective and prospective study. This study was carried out in the Haematology Department of CHK-Central Laboratory from Jan 2018- till date. Methodology: Bone marrow examination of 280 cases of suspected hematological disorders was carried out, who presented to CHK-Central Laboratory for bone marrow Biopsy. Complete detailed history, examination and complete blood counts were recorded. Results: Among 280 cases studied, age of patients ranged from 02 to 75 years with mean age of 38.5 years with male predominance (1.4:1). Most of the patients presented with fever, easy fatigability and generalized weakness. Out of 280 cases of bone marrow biopsy 57 ( 20.3% ) cases showed normal haematopoiesis, while Erythroid Hyperplasia was observed in 10(3.5%) cases and Megaloblastic Anaemia in 05(1.7%) cases. ITP in 15 (5.3%), Hypocellular marrow in 19 (6.7%), Aplastic Anaemia in 24(8.5%) cases. Acute leukemia was seen in 46 cases with 23 (8.2%) cases of ALL and 12(4.2%) cases of AML. CML was seen in 37(13.2%), MPN in 10(3.5)% cases, LPD in 23 (8.2%) cases, Multiple myeloma in 02(0.7%). 01 case (0.3%) of granulomatous pathology and 01 case (0.3%) of Myelodysplastic syndrome were diagnosed exclusively on bone marrow biopsy. Leishmaniasis seen in 1 0.3(%) patient. In addition metastatic deposits of adenocarcinoma were observed in 2(0.7%) cases. Conclusion: The present study showed the usefulness of bone marrow aspiration and trephine biopsy in evaluation of the bone marrow in routine haematological disorders and also for understanding disease progression.
POEMS syndrome presenting with colonic pseudoobstruction and calciphylaxis
Authors: Katiyar Vatsala , Araujo Tiago , Kerlos Mina , Bhattacharjee Poushali , Kumssa Adamsu
Published: March 2022

Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes (POEMS) syndrome is a rare and poorly understood paraneoplastic syndrome driven by monoclonal plasma cell dyscrasia. Common presenting symptoms include neuropathy, endocrine dysfunction, skin changes, and volume overload. Here we describe a young female with history of neuropathy who presented to our hospital with abdominal pain and was found to have persistent colonic pseudo-obstruction .She was diagnosed with POEMS syndrome based on the International Myeloma Working Group diagnostic criteria and her intestinal dysmotility was thought to be a consequence of the underlying syndromic condition. To our knowledge, this is the first case of POEMS syndrome presenting with intestinal pseudo-obstruction.
A review on particulate matter and heavy metal emissions; impacts on the environment, detection techniques and control strategies
Authors: Asif Muhammad , Yousuf Sayyaf , Donald Anyiam Ngozi , Hassan ABU MD. Mehdi , Iqbal Asif , Bodlah Muhammad Adnan , Sharf Bushra , Noshia Noshaba
Published: March 2022

Population growth, Urbanization and Industrialization created many social economic environmental and health issues for Pakistan. Industries are major sources of environmental pollution specially water and air pollution due to lack of advanced technologies. This review mainly focused on the emission of heavy metals from industries, their detection methods which are available in Pakistan. Heavy metals are released into the environment through different industries and combine with other pollutants to form secondary compounds which are even more harmful to the environment. When these heavy metals combine with water and soil, they change the soil and water ecosystem functions, plant growth mechanism and disrupt the many other functions of soil. More so, groundwater contamination owing to these metals poses many serious health problems in humans and animals, and when this groundwater mixes with sea water, it threatens the health of aquatic lives and food species growing in water and bioaccumulated in the food chain of biological system. By using advanced detection, controlled and treatment technologies, ecosystem can be saved from the possible problem of heavy metal emissions and contamination.
Laparoscopic excision of tubocutaneous fistula: case report
Authors: Ganesh Deepa , Rajkumar JS , Syed Akbar , Rajkumar Anirudh , Reddy Jayakrishna
Published: March 2022

Gynecological fistulas that are familiar are vesicovaginal, rectovaginal and ureterovaginal fistulas, which may be due to childbirth, operative injury, tumour or radiation. Tubocutaneous fistula, is as a very rare condition secondary to tuberculosis, endometriosis, and complications of child birth and gynecological surgeries. We report a 30 year old woman with a tuberculous tubocutaneous fistula, arising from the right salphingeal tube and discharging in the lower abdomen cutaneously, who underwent laparoscopic right salpingo oophorectomy, and excision of the tract upto the skin, and the abdominal wall, with open excision of the distal part. The case is being published for its rarity, and to remind gynecologists to consider this possibility in a non-healing sinus in the lower abdomen. The authors believe this to be the first such case in literature.
ЕКОНОМІЧНА БЕЗПЕКА РЕГІОНІВ УКРАЇНИ
Authors: ГАРЬКАВА Вікторія
Published: March 2022

Обґрунтовано важливість економічної безпеки як складової національної безпеки України, розкрито поняття «економічна безпека», проаналізовано причини її загроз, а саме зовнішньоекономічні, зовнішньополітичні та внутрішні. Проаналізовано властивості та розкрито роль економічної безпеки регіону як самостійної економічної категорії. Показано різні точки зору на поняття «економічна безпека», виділено основні наукові підходи до визначення даного поняття. Розглянуто категорію «економічна безпека на регіональному рівні» як багатокомпонентне явище, суму окремих його складових. Показано напрями забезпечення економічної безпеки держави на регіональному рівні. Проаналізовано функціональні особливості системи досягнення економічної безпеки, наведено функції економічної безпеки на державному та регіональному рівнях, а саме захисну, регулятивну, превентивну, інноваційну, діагностичну, соціальну. Окреслено характеристики, досягнення яких забезпечить комплексна реалізація наведених функцій, зокрема, виокремлено стійкість до екзогенних і ендогенних загроз, здатність регіональної економічної системи до самовідтворення й саморозвитку, економічну самодостатність, міцність зв’язків між елементами регіональної економіки, здатність до використання конкурентних переваг, відповідність складників економічної безпеки регіону нормативному рівню, збалансованість міжрегіональних відносин.Названо головні проблеми, що сьогодні загрожують національній економічній безпеці на рівні регіонів, виокремлено головні загрози економічній безпеці регіонів та основні напрями стратегії оптимізації економічної безпеки. Зроблено висновок, що в усьому розмаїтті проблем національної економічної безпеки країни чітко виокремлюється регіональний аспект. Доведено, що досягнення економічної безпеки регіону забезпечує соціально-економічну і суспільно-політичну стабільність, належний рівень та якість життя населення. Для досягнення максимального ефекту програмно-цільового управління необхідно забезпечити повноту цільової комплексної програми економічної безпеки регіону, яку слід реалізовувати поетапно.
НАУКОВО-ТЕХНОЛОГІЧНЕ ТА ІННОВАЦІЙНЕ СПІВРОБІТНИЦТВО МІЖ УКРАЇНОЮ ТА ЄВРОПЕЙСЬКИМ СОЮЗОМ: ПЕРСПЕКТИВИ І СТРАТЕГІЧНІ НАПРЯМИ РОЗВИТКУ
Authors: ПІДОРИЧЕВА Ірина
Published: March 2022

В умовах нормальності 2.0, кардинальних технологічних трансформацій, що відбуваються у світовій економіці під впливом Четвертої промислової революції, пріоритетного значення набуває поглиблення міжнародного співробітництва, що сприятиме сталому розвитку країн. В основі стратегічного зовнішньополітичного курсу України лежить європейська інтеграція, яка передбачає розвиток відносин з Європейським Союзом та його державами-учасницями в багатьох сферах, які становлять спільний інтерес. Однією з таких сфер є науково-технологічна та інноваційна – ключова з точки зору забезпечення інноваційної конкурентоспроможності й технологічної безпеки країн у довгостроковій перспективі.Досліджено особливості інноваційної політики ЄС у контексті реалізації його нового стратегічного курсу щодо розбудови кліматично нейтральної, більш «зеленої», цифрової, справедливої та демократичної Європи. Визначено підходи, які закладено в основу сучасної інноваційної політики ЄС: підхід смарт-спеціалізації та підхід до інновацій, орієнтованих на місію. Особливу увагу приділено останньому, висвітлено суть місій та місієорієнтованої інноваційної політики, показано їх роль у досягненні Цілей сталого розвитку.Визначено стратегічні пріоритетні напрями науково-технологічного та інноваційного співробітництва між Україною та ЄС з урахуванням національних і глобальних викликів, потенціалу і здобутків вітчизняної науки, нових стратегічних цілей Європейського Союзу та особливостей загальноєвропейської інноваційної політики. Детально обґрунтовано доцільність і перспективи співробітництва сторін за чотирма з виокремлених напрямів, які передбачають розвиток співробітництва у таких сферах: по-перше, безпеки, оборонно-технічного й оборонно-промислового співробітництва; по-друге, охорони здоров’я та фармакології, біотехнологій та геноміки; по-третє, сільського господарства та харчової промисловості, зокрема органічного фермерства і точного рільництва; по-четверте, цифровізації та розвитку цифрових технологій. Узагальнено інституційні засади співробітництва України та ЄС у цих сферах і надано пропозиції щодо зміцнення науково-технологічного та інноваційно-промислового потенціалу України як передумови її ефективної інтеграції в Європейський дослідницький простір.
КОНФЛІКТНІСТЬ У ВЗАЄМОДІЇ ЕКОНОМІКИ І ПРИРОДИ ТА РОЛЬ АГРОЕКОЛОГІЇ ЯК ВАЖЛИВОГО СПОСОБУ ЇЇ УПЕРЕДЖЕННЯ
Authors: МОЛДАВАН Любов
Published: March 2022

Розкрито сутність антагонізму взаємовідносин між суб’єктами і об’єктами людської діяльності, що виникають у системі "людина –– суспільство –– економіка –– природа", та їх переростання в соціально-екологічні конфлікти. Останні характеризуються такими відносинами між ними, за яких кожна із сторін відображає протилежну позицію по відношенню до впливу економіки на екологію, і навпаки. Обґрунтовано місце і роль у загостренні економіко-екологічних конфліктів концепції економічного зростання, яке забезпечується випереджальним нарощуванням масштабів та інтенсивності споживання продуктивної сили природного ресурсу. Викладено головні принципи концепції сталого розвитку, основою якого є паритетність відносин між людиною, економікою і природою, що нейтралізує виникнення економіко-екологічних конфліктів.Виокремлено поетапність наростання екодеструктивного впливу економіки на природні ресурси сільського господарства –– основної галузі життєзабезпечення суспільства, охарактеризовано кожний етап. Доведено, що неузгодженість нарощування валового виробництва сільськогосподарської продукції в Україні з вимогами сталого (економіко-соціально-екологічно збалансованого) розвитку галузі досягла рівня антропогенного навантаження на природний сільськогосподарський ресурс, який наближається до граничної лінії, за якою починаються і стають загрозливими для виробництва та життя людей кризові зміни в природних, насамперед земельних, ресурсах,Обґрунтовано місце агроекології в переході до економіко-соціально-екологічно збалансованого розвитку, охарактеризовано її сутність як галузі науки та основні принципи. Визначено відмінності між індустріально-інтенсивним і агроекологічним сільським господарством. Розкрито роль останнього в збереженні та нарощуванні продуктивної сили сільськогосподарських угідь у довгостроковому періоді, адаптації галузі до змін клімату і сприяння їх пом'якшенню, покращенні харчування людей, скороченні масштабів безробіття і бідності в сільських районах. Сформульовано на основі документів ООН і Європейського Союзу рекомендації щодо вжиття заходів з імплементації наукових розробок і передових практик переходу від індустріально-інтенсивного екологоруйнівного до сталого агроекологічного виробництва в аграрну політику України.
Health Care Clinicians and Product Promotion by Industry
Authors: Diekema Douglas S.
Published: March 2022

Medical pharmaceutical and device manufacturers are essential in making products that benefit patients, and collaboration between health care providers and industry is necessary in the design, testing, and manufacture of these medical products. However, health care providers must recognize that their duties and the interests of industry may, at times, diverge. Relationships with industry, even seemingly minor ones, have the potential to shape the decisions made on behalf of patients. The marketing divisions of pharmaceutical and medical device firms view health care providers as a target of their efforts, and some of the interactions that occur between industry and health care providers have the potential to alter decision making in ways that may not necessarily benefit patients. Health care providers have an ethical duty to recognize situations and marketing strategies that are designed to influence their choice of diagnostic and therapeutic options for their patients. Health care providers should be aware of the techniques used to attempt to alter their behavior and guard against them.
Cross-Country Analysis of Competitiveness Towards Innovation Potential Assessment for Industrials
Authors: Shvindina Hanna , Taraniuk Leonid , Kotenko Stanislav , Awujola Abayomi , Taraniuk Karina , Hongzhou Qiu
Published: March 2022

The global competitiveness report reveals cross-regional and cross-country disparities, and the innovation development of industrials shows how difficult it is to build and support competitiveness at a high level and increase innovation potential. The bibliometric analysis proves the diversity of the studies in the field and the increasing trend in paper production. The lack of understanding of the link between different levels of competitiveness and the need to monitor and forecast innovative development necessitated the cross-country benchmarking of industrials' innovation potential. The offered methodology is a seven-stage algorithm of innovation potential assessment, based on an existing GCI methodology modified to reveal innovation development differences, and tendencies for particular industries. The ranking was performed for major industrial countries to reveal the gaps in innovative activities and develop catch-up strategies.
Bank Concentration and Stability in Central Asia: The Effect of Capital Regulation and Financial Freedom
Authors: Yudaruddin Rizky
Published: March 2022

In this study, the interrelation between bank concentration and stability is examined, focusing on the joint impact of capital regulation and financial openness. Using the data from the Global Financial Development Database provided by the World Bank and the Index of Financial Freedom from The Heritage Foundation and The Wall Street Journal, a sample of five countries in Central Asia was obtained, specifically during 1993-2017. The results show that the relationship between bank concentration and stability supports the concentration-stability hypothesis. Moreover, higher concentration and well-capitalized banks increase financial stability. However, the effect of bank concentration and financial freedom on stability is negative and significant. Capital regulation and supervision from authority control in the financial sector need to be strengthened to solve financial instability.
The Influence of the Generation Z’s Perception and Psychological Ownership on repurchase Intention of e-shopping: Evidence from Vietnam
Authors: Nguyen Diep Thi N. , Hoang Sinh Duc , Chovancová Miloslava , Tran Khang Hoang
Published: March 2022

One of the most significant achievements of Information Communication Technology (ICT) in commerce is e-shopping, which changes shopping behavior in the retail sector. This research examines how Generation Z’s perceptions of e-shopping benefits and drawbacks and A qualitative method through in-depth interviews and a quantitative method via a questionnaire survey is employed to assess the Generation Z-ers’ attitudes, perceptions, and psychology toward the benefits and drawbacks of e-shopping and their intention of choosing this channel for repurchasing. PLS-SEM will be associated to discover the relationships between Generation Z-ers’ psychological ownership, perceptions of e-shopping benefits and drawbacks, and their online repurchase intention. Findings suggest that Generation Z-ers’ online repurchase intention is due to perceived benefits, psychological ownership, and is regardless of perceived drawbacks. Furthermore, as a moderator of the effect of perceived drawbacks on repurchase intention, psychological ownership may lessen the Generation Z-ers’ concerns of e-shopping drawbacks and enhance their online repurchase intention.
Effect of Social Marketing on Health Protocol Compliance Among Millennials in Jakarta, Indonesia
Authors: Simamora Virgo , Rachma Siti
Published: March 2022

Individual compliance with health protocols is a crucial factor in supporting Indonesian government in controlling the transmission of COVID-19, especially the millennial generation. This explanatory research aims to examine the effect of social marketing on compliance among millennials in Jakarta. Four indicators are applied to measure social marketing, and other two are applied to measure compliance. Using the questionnaire, the researcher collected data from 439 millennials. The hypothesis was tested using the partial least squares structural equation modeling (PLS-SEM). This study found that social marketing positively impacts compliance with health protocols. These findings have provided some empirical implications about how crucial social marketing increases millennials’ compliance with health protocols promoted to prevent and control COVID-19 transmission. The concept of the marketing mix, informing people about the benefits of health is critical since the social positive values offered by social marketers are a major incentive for people to follow health protocols.
Benefits and Risks of Digital Business Transformation: The Example of Eastern Europe Countries
Authors: Zolkover Andrii , Petrunenko Iaroslav , Iastremska Olesia , Stashkevych Oksana , Mehdizade Mehriban Mehdiqizi
Published: March 2022

The purpose of this research was to conceptually substantiate an effective business digitalization strategy in Eastern Europe (EE), taking into account the identification of destructive and complementary factors of digital transformation (DT). The survey, completed by top managers of companies from different sectors of the EE countries' economy, helped form a system of indicators for assessing the level of DT by country.  The systematization of the DT factors made it possible to differentiate them by the nature of influence, advantages, and threats of the DH (digital humanities) for the EE countries. The results indicated a low and medium level of DT in the countries studied because of the lack of a digitalization strategy. A matrix of business digitalization management strategies has been formed for Eastern European countries, considering the efficiency level, digitalization threats, and the priority in their management.  It will help mitigate the threats of DT and reduce the digital divide with countries with a high level of DT.
The «Five-Helix» Model as an effective way to develop business in Industry 4.0 of selected countries
Authors: Megits Nikolay , Aliyev Shafa T. , Pustovhar Svitlana , Bielialov Taliat , Prokopenko Olha
Published: March 2022

This article aims to assess the potential of using the components of the five-helix model in countries with different levels of business development in Industry 4.0 for the US, Azerbaijan, Ukraine, and Poland. We determined the stimulators and not stimulators of the company development interacting with the participants of the innovation system: "business," "society," "state," "science," and "environment." We empirically evaluated the company’s ability to use the potential of the five-helix model during the transition to Industry 4. These estimates, along with the development indicators of the five-fold spiral elements, were used to build a decision tree for choosing a practical scenario for business development and information transformation. It helped determine options for ensuring business efficiency, depending on the development of the five helix components and the company's ability to use their development potential.
Predictional factors of efficiency of myfipristone in pre-induction cervical ripening
Authors:   SHEIU «Bukovinian state medical University», Chernivtsi, Kravchenko О.V.
Published: March 2022

The objective: to study clinical and ultrasound criteria, which are prognostically important in determining the effectiveness of pre-induction and induction of labor by mifepristone. Materials and methods. 192 patients were examined during the gestation period of 40–42 weeks, with mifepristone (mirapriston) used to prepare the cervix for delivery. The effectiveness of pre-induction preparation of mifepristone was assessed by the following criteria: maturation of the cervix, the need for additional induction methods, the independent initiation of regular labor, the development of abnormalities of labor, the frequency of delivery through the natural birth canal and by cesarean section, neonatal outcomes. Results. It was found that before the reception of mifepristone the cervix was evaluated as «immature» in 59.9% of pregnant women, in 40.1% of patients it was «not mature enough». Self-sustained labor after pre-induction with mifepristone developed in 83.3% of women. 2.6% of pregnant women were operated in a planned manner due to the lack of effect from pre-induction training. In 16.7% of the patients, deliveries ended by an urgent cesarean section. The main prognostic factors for the effectiveness of pre-induction preparation are the length of the cervix, the age of the pregnant woman, the dose ratio of mifepristone and the body weight of the woman. Conclusion. Use of mifepristone is a highly effective method of preparing the body for pregnant women to delivery. The appointment of mifepristone promotes spontaneous development of labor activity in 79.3% of pregnant women. The highest percentage of success in pre-induction with mifepristone was observed with a cervical length of 25 mm or less. The age of a pregnant woman over the age of 30 is a prognostic factor of the less effective mifepristone in preparing the cervix to delivery than before age 30. The dose ratio of mifepristone and the body weight of the patient have great prognostic value as for to the maturation of the cervix and for the characteristics of the course of the normal labor. The use of mifepristone does not lead to a negative effect of the fetal condition and involutive processes of myometrium in postpartum period. Key words: efficacy factors, pre-induction preparation, mifepristone.
PRODUCTION OF BIOSORBENTS FROM WASTE OF PROCESSING OF PLANT RAW MATERIALS AND THEIR APPLICATION IN WATER TREATMENT TECHNOLOGIES
Authors: Kovalenko Olena , Kokhanska Anna
Published: March 2022

The article shows the situation with the production of plant raw materials processing waste, their impact on the environment, in particular, water resources. It is noted that one of the reasons for the aggravation of water problems is the discharge of untreated wastewater into water bodies, namely, by food industry enterprises. It is substantiated that developing and implementing technologies for obtaining water treatment materials from plant processing waste can solve a number of important problems for humanity. Such materials are biosorbents, which together with activated carbon obtained from fossil fuels and charcoal, belong to the group of sorption materials with a high carbon content of organic origin. An overview of the technological schemes and processes of obtaining such materials is presented. The reagents and technological parameters for the main processes are specified. It is shown that it is possible to obtain a porous material with a high carbon content and functional groups capable of ion exchange or complexation by slow pyrolysis (or carbonization). The quantitative and qualitative composition of the biosorbent, its characteristics and ability to remove impurities from water influenced by technological modes of raw materials processing, their sequence, number and type of oxidants and other reagents, chemical composition of raw materials, etc. are presented. The properties of biosorbents and their efficiency in removing various impurities from water were analyzed on the example of biosorbents obtained from pea leaves, sunflower and vine. The technical and economic aspects of creating the production of biosorbents for water treatment are formulated. It is emphasized that in order to create efficient production of biosorbents in addition to energy efficient and environmentally friendly technology, it is important to take into account the productivity of the source of raw materials, their chemical composition and shelf life, transport conditions for processing, etc. The prospects for the use of tomato processing waste as a raw material for the production of materials for water treatment are evaluated. It is mentioned that in Ukraine there is a demand for effective solutions for the disposal of these wastes. The analysis of researches of methods of reception of biosorbents from wastes of tomatoes processing and their application for extraction from water of impurity of various nature is resulted. It is shown that this area of research is promising, but still not studied enough.
БЕЗПЕКА І МІКРОБІОЛОГІЧНА ЧИСТОТА СУХОГО КОБИЛЯЧОГО ТА ОВЕЧОГО МОЛОКА ДЛЯ ВИРОБНИЦТВА ДИТЯЧОГО ХАРЧУВАННЯ
Authors: Белінська Крістіна Олександрівна
Published: March 2022

Сьогодні гостро стоїть питання забруднення ґрунтів та водних ресурсів планети. У зв’язку з цим продукти тваринництва, які споживає людина, також містять шкідливі забруднюючі речовини. Актуальним є вивчення показників безпеки молока. Враховуючи актуальність проблеми щодо безпеки молока при оцінці мікробіологічного ризику стосовно небезпечних мікроорганізмів, які викликають харчові захворювання у дітей, доцільним є акцентувати увагу на цій проблемі, зокрема на необхідності проведення досліджень по даному напрямку. Для виготовлення молочно-борошняних каш використовують переважно коров’яче молоко. У зв’язку з частою непереносимістю дитячим організмом білків коров’ячого молока доцільно розробляти аналогічні продукти на основі кобилячого та овечого молока. Сушіння кобилячого та овечого молока проводили на розпилювальній сушарці «Ниро-Атомайзер». Сушіння кобилячого молока проводили за температури 140-150 0С, овечого – 170-180 0С. Молоко було зібрано з фермерських господарств різних регіонів країни. Для розробки молочно-борошняних каш використовували екструдоване борошно вітчизняного виробництва. Молочно-борошняні каші зберігалися в картонних пачках з внутрішнім пакетом із комбінованого полімерного матеріалу. Повітря із пакету видаляли і замінювали азотом, пакет герметично закривали шляхом спайки верхнього клапана. Дослідження проводили за стандартними методиками. З’ясовано, що сухе молоко за показниками безпеки та мікробіологічними показниками відповідає вимогам. В розроблених молочно-борошняних кашах на основі сухого кобилячого та овечого молока шкідливі речовини та мікроорганізми також не перевищують гранично допустимі межі. З’ясовано, що молочно-борошняні каші не мають ознак мікробіологічного псування впродовж 12 місяців зберігання. Отже, сухе кобиляче та овече молоко є перспективною сировиною для виробництва продуктів для дитячого харчування.
The relationship between mobbing, alienation and burnout among teachers in Mersin, Turkey
Authors: İnandi Yusuf , Büyüközkan Ayşe Sezin
Published: March 2022

The relationship between mobbing behaviour, alienation and burnout experienced by teachers in the elementary schools in central districts of Mersin was investigated in the study reported on here. The sample of this study consisted of a group of 455 randomly selected teachers selected by the simple random sampling method. The mobbing scale, alienation scale and Maslach Burnout Inventory were used in the study, and data were analysed by using the correlation and regression techniques. As a result, there is a positive and significant relationship between mobbing behaviour experienced by the teachers and their alienation. Also, mobbing behaviour of school administrators were found to be positively associated with teachers’ burnout. Furthermore, mobbing behaviour significantly predict all other dimensions of alienation, except for school alienation dimension, and all dimensions of burnout.
Malnutrition as a factor aggravating the heart failure course in the elderly and senile age
Authors: Tkacheva O. N. , Kotovskaya Yu. V. , Krylov K. Yu. , Eruslanova K. A. , Fedin M. A.
Published: March 2022

Cardiovascular diseases are the main death causes in the modern world. Heart failure (HF) is the terminal stage of most cardiovascular diseases. The prevalence of HF is increasing in patients of older age groups. At the same time, the number of geriatric syndromes increases with age, one of which is malnutrition. Recent studies demonstrate the mutually aggravating effect of heart failure and malnutrition, and that the correction of malnutrition can improve the heart failure course. The introduction of screening and timely correction of malnutrition will reduce the hospitalization and mortality rates in geriatric patients with HF.
Association of rivaroxaban and apixaban therapy with major ischemic or bleeding events in patients with atrial fibrillation. Retrospective cohort real-world evidence study. Press release
Authors: Editorial Article
Published: March 2022

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Experimental investigation of a keying joint cast in UHPFRC between precast UHPFRC bridge elements
Authors: Bertola Numa J. , Trinh Ngoc Thanh , Garcia Enrique , Brühwiler Eugen
Published: March 2022

Ultra High-Performance Fiber-Reinforced Cementitious Composite (UHPFRC) is increasingly popular for new structural designs thanks to its high resistance both in tension and compression. When UHPFRC is complemented with steel reinforcing bars or prestressing tendons, the structure remains waterproof and crack-free under service conditions, significantly improving the durability compared to conventional reinforced-concrete designs. The Aiguillon Bridge is one of the first railway bridges entirely made of UHPFRC. Built in 2021 in Switzerland, this bridge has a single span of 6.6 m and a width of 5.4 m. The bridge is designed for a narrow track and 2 walkways. Two prefabricated elements in UHPFRC have been assembled on-site by a longitudinal cast-in-place UHPFRC keying joint. This paper presents the full-scale laboratory experiment to validate the keying joint suitability for railway bridges. This experimental investigation involves a static test on a transverse beam composed of two precast elements and the keying joint. Results show that the structure presents a post-peak ductile behavior as well as an elastic behavior under service loads. Digital-Image-Correlation measurements provide details on the cracking patterns of the interface between the keying joint and the precast elements. As the maximum resistance obtained during the experiment is in agreement with the analytical-model predictions, the concept of the keying joint is validated.