bluuebunny/crossref_metadata_2025 huggingface dataset:
Ligand Binding Prediction Using Protein Structure Graphs and Residual Graph Attention Networks
Authors: Pandey Mohit , Radaeva Mariia , Mslati Hazem , Garland Olivia , Fernandez Michael , Ester Martin , Cherkasov Artem
Published: August 2022

Computational prediction of ligand–target interactions is a crucial part of modern drug discovery as it helps to bypass high costs and labor demands of in vitro and in vivo screening. As the wealth of bioactivity data accumulates, it provides opportunities for the development of deep learning (DL) models with increasing predictive powers. Conventionally, such models were either limited to the use of very simplified representations of proteins or ineffective voxelization of their 3D structures. Herein, we present the development of the PSG-BAR (Protein Structure Graph-Binding Affinity Regression) approach that utilizes 3D structural information of the proteins along with 2D graph representations of ligands. The method also introduces attention scores to selectively weight protein regions that are most important for ligand binding. Results: The developed approach demonstrates the state-of-the-art performance on several binding affinity benchmarking datasets. The attention-based pooling of protein graphs enables identification of surface residues as critical residues for protein–ligand binding. Finally, we validate our model predictions against an experimental assay on a viral main protease (Mpro)—the hallmark target of SARS-CoV-2 coronavirus.
Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy
Authors: Bakulina Olga , Ivanov Mikhail , Alimov Dmitriy , Prikhod’ko Sergey , Adonin Nicolay , Fedin Matvey
Published: August 2022

Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs) draw increasing interest as a particular class of ILs that possess unusual physicochemical properties along with simultaneous potentials for pharmaceutical applications. Although nanostructuring phenomena were actively investigated in common ILs, their studies in API-ILs are scarce so far. In this work, using the complex methodology of Electron Paramagnetic Resonance (EPR) and dissolved spin probes, we investigate nanostructuring phenomena in a series of API-ILs: [Cnmim][Ibu], [Cnmim][Gly], and [Cnmim][Sal] with n = 2, 4, and 6, respectively. We reveal similar trends for API-ILs and common ILs, as well as peculiarities inherent to the studied API-ILs. Unusual behavior observed for [Cnmim][Ibu] has been assigned to the presence of a non-polar fragment in the [Ibu]− anion, which leads to the formation of more complex nanostructures around the radical compared to common ILs. Understanding general trends in the formation of such self-organized molecular structures is of fundamental interest and importance for applying API-ILs.
Genomic Insights into Cultivated Mexican Vanilla planifolia Reveal High Levels of Heterozygosity Stemming from Hybridization
Authors: Ellestad Paige , Pérez-Farrera Miguel Angel , Buerki Sven
Published: August 2022

Although vanilla is one of the most valuable spices, there is a lack of understanding of the genomic variability of the main vanilla producing species, Vanilla planifolia, within its cultivated origin, Mexico. High genomic heterozygosity levels within the globally cultivated ‘Daphna’ genome have raised questions on the possibility of a hybrid origin and analogous genomic signatures of vanilla cultivated within its origin. This study investigated these questions by assessing whether the genomic structure of Mexican V. planifolia reflected domestication events. Whole genome re-sequencing was used to compare genome complexity between 15 cultivated accessions from different regions and gene pools. Results showed high levels of heterozygosity, ranging from 2.48% to 2.85%, in all but one accession, which exhibited a low level (0.403%). Chromosome-level comparative analyses revealed genomic variability among samples, but no signals of chromosome rearrangements. These findings support the hypotheses that cultivated vanilla resulted from hybridization and that multiple domestication events have shaped cultivated vanilla leading to the formation of landraces. High cultural diversity within this region further supports the occurrence of multiple domestication processes. These results may help to improve breeding and conservation efforts aiming to preserve the genetic diversity of this beloved spice threatened by climate change.
An Improved Model for Predicting the Drag Coefficient and Terminal Settling Velocity of Natural Sands in Newtonian Fluid
Authors: Ma Xiao , Ji Guodong , Li Zijian , Ju Guoshuai
Published: August 2022

The drag coefficient CD plays an important role in studying the interaction forces between individual particles and fluid. Due to the irregular particle shape of natural sands, studying the sedimentation characteristics and drag coefficient model of irregular particles is of great significance in explaining natural phenomena, predicting the sedimentation process, and calculating the interphase forces between individual particles and fluid. In this paper, firstly, an experimental system for measuring the settling velocity was built, the settling velocity of 67 tests of spheres with different particle Reynolds number Res in the Newtonian fluid were obtained, and the CD–Res correlation of sphere settling in the Newtonian fluid was established. The proposed CD–Res correlation was in good agreement with the existing classical CD–Res correlations, which proves the reliability of the experimental system and data processing method. Existing literature shows that the previous models are only suitable for irregular-shaped particles with three-dimensional shape-described parameters. However, the three-dimensional shape information of sand particles can only be obtained through accurate laboratory measurements, and it is often impossible to calculate accurately. By introducing the two-dimensional shape-described parameter (circularity c), using image analysis technology, the two-dimensional shape information of natural sands was obtained. The settling velocity of 221 tests of natural sands in the Newtonian fluid was obtained experimentally. It is found that the sand particles’ drag force exerted by the fluid is more significant than its equivalent sphere. With the increase in the particle Reynolds number, the shape irregularity’s influence on sand particle drag coefficient is more significant, and the CD–Res correlation of natural sand was proposed by fitting. The established CD–Res correlation has good prediction accuracy and can better predict the drag coefficient and terminal settling velocity of natural sand with irregular shapes.
Thermal Safety Evaluation of Silane Polymer Compounds as Electrolyte Additives for Silicon-Based Anode Lithium-Ion Batteries
Authors: Zhang Chuan-Zhu , Xie Lin-Jie , Tang Yan , Li You , Jiang Jun-Cheng , Huang An-Chi
Published: August 2022

The capacity fading and thermal safety issues caused by the volume effect of Si-based anodes and unstable solid electrolyte interphase (SEI) films during long-term cycling limit its large-scale application. In this study, silane polymer compound (2-cyanoethyl) triethoxysilane (TCN) was selected as an electrolyte additive to improve the reversibility and thermal safety of Si-based anode lithium-ion batteries (LIBs). TCN prevented the thermal interaction between the vitiated anode and electrolyte, and the onset temperature of the thermal reaction increased from 122.22 to 127.07 °C, as demonstrated by the results of thermogravimetric analysis and differential scanning calorimetry. The thermal stability of lithiated anodes containing various electrolytes was then assessed using a range of thermo-kinetic models. The results revealed that the activation energy of Si-based lithiated anodes increased from 68.46 to 91.32 kJ/mol, while the thermal hazard greatly decreased. Additionally, the electrochemical test and characterization results showed that TCN helped generate a stable SEI coating with more Li2CO3 components, which improved the cells’ cycle stability. This study provides a new reference for the growth of LIBs with high security and energy density.
Modeling and Optimization of Assembly Line Balancing Type 2 and E (SLBP-2E) for a Reconfigurable Manufacturing System
Authors: Khan Abdul Salam , Khan Razaullah , Saleem Waqas , Salah Bashir , Alkhatib Soliman
Published: August 2022

This study undertakes the line balancing problem while allocating reconfigurable machines to different workstations. A multi-objective model is used to analyze the position of workstations, assignment of configurations to workstations, and operation scheduling in a reconfigurable manufacturing environment. A model is presented that comprises the objectives of the Total Time (TT), the Line Efficiency Index (LEI), and the Customer Satisfaction Index (CSI). The objective is to minimize the completion time and maximize the efficiency of a production line. The proposed model combines the Simple Line Balancing Problems Type 2 and Type E in the form of SLBP-2E. The presented problems are addressed by using a heuristic solution approach due to non-polynomial hard formulation. The heuristic approach is designed to assess different solutions based on no repositioning, separate repositioning of workstations and configuration, and simultaneous repositioning of workstations and configurations. A detailed assessment is presented regarding the efficiency as well as the effectiveness of proposed approaches. Finally, conclusions and future research avenues are outlined.
Performance Analysis of Dual-Hop AF Relaying with Non-Linear/Linear Energy Harvesting
Authors: Babaei Mohammadreza , Durak-Ata Lütfiye , Aygölü Ümit
Published: August 2022

Massive device-to-device communication nodes and Internet of Things (IoT) devices are expected to be crucial components in next-generation wireless networks. However, the energy constraint of these nodes presents a challenge since the energy of the batteries is limited. Motivated by this, radio frequency energy harvesting (EH) has been developed as an efficient strategy to overcome the energy constraint of IoT devices and sensor networks. In this paper, a wireless-powered dual-hop amplify-and-forward relaying system, in the absence of a direct link between the source (S) and the destination (D), is considered. It is assumed that a dedicated power beacon (PB) transmits an energy-bearing signal from which the power-constrained S and relay (R) harvest energy. Theoretical derivations of bit error probability, outage probability, and throughput expressions are performed for both linear and non-linear energy harvesting models. Moreover, the theoretical results provided for different system parameters are validated via Monte Carlo simulations. The obtained results reveal the difference between the realistic non-linear EH model and the conventional linear EH model, which overestimates the system performance at high levels of harvested energy. Thus, it leads to misunderstanding the real performance of the EH systems. However, at low levels of harvested energy, both models behave similarly and provide realistic results.
A Scoping Review on Wearable Devices for Environmental Monitoring and Their Application for Health and Wellness
Authors: Bernasconi Sara , Angelucci Alessandra , Aliverti Andrea
Published: August 2022

This scoping review is focused on wearable devices for environmental monitoring. First, the main pollutants are presented, followed by sensing technologies that are used for the parameters of interest. Selected examples of wearables and portables are divided into commercially available and research-level projects. While many commercial products are in fact portable, there is an increasing interest in using a completely wearable technology. This allows us to correlate the pollution level to other personal information (performed activity, position, and respiratory parameters) and thus to estimate personal exposure to given pollutants. The fact that there are no univocal indices to estimate outdoor or indoor air quality is also an open problem. Finally, applications of wearables for environmental monitoring are discussed. Combining environmental monitoring with other devices would permit better choices of where to perform sports activities, especially in highly polluted areas, and provide detailed information on the living conditions of individuals.
Comparative Analysis of Multilayer Lead Oxide-Based X-ray Detector Prototypes
Authors: Pineau Emma , Grynko Oleksandr , Thibault Tristen , Alexandrov Alexander , Csík Attila , Kökényesi Sándor , Reznik Alla
Published: August 2022

Lead oxide (PbO) photoconductors are proposed as X-ray-to-charge transducers for the next generation of direct conversion digital X-ray detectors. Optimized PbO-based detectors have potential for utilization in high-energy and dynamic applications of medical X-ray imaging. Two polymorphs of PbO have been considered so far for imaging applications: polycrystalline lead oxide (poly-PbO) and amorphous lead oxide (a-PbO). Here, we provide the comparative analysis of two PbO-based single-pixel X-ray detector prototypes: one prototype employs only a layer of a-PbO as the photoconductor while the other has a combination of a-PbO and poly-PbO, forming a photoconductive bilayer structure of the same overall thickness as in the first prototype. We characterize the performance of these prototypes in terms of electron–hole creation energy (W±) and signal lag—major properties that define a material’s suitability for low-dose real-time imaging. The results demonstrate that both X-ray photoconductive structures have an adequate temporal response suitable for real-time X-ray imaging, combined with high intrinsic sensitivity. These results are discussed in the context of structural and morphological properties of PbO to better understand the preparation–fabrication–property relationships of this material.
Dissecting Latency in 360° Video Camera Sensing Systems
Authors: Yan Zhisheng , Yi Jun
Published: August 2022

360° video camera sensing is an increasingly popular technology. Compared with traditional 2D video systems, it is challenging to ensure the viewing experience in 360° video camera sensing because the massive omnidirectional data introduce adverse effects on start-up delay, event-to-eye delay, and frame rate. Therefore, understanding the time consumption of computing tasks in 360° video camera sensing becomes the prerequisite to improving the system’s delay performance and viewing experience. Despite the prior measurement studies on 360° video systems, none of them delves into the system pipeline and dissects the latency at the task level. In this paper, we perform the first in-depth measurement study of task-level time consumption for 360° video camera sensing. We start with identifying the subtle relationship between the three delay metrics and the time consumption breakdown across the system computing task. Next, we develop an open research prototype Zeus to characterize this relationship in various realistic usage scenarios. Our measurement of task-level time consumption demonstrates the importance of the camera CPU-GPU transfer and the server initialization, as well as the negligible effect of 360° video stitching on the delay metrics. Finally, we compare Zeus with a commercial system to validate that our results are representative and can be used to improve today’s 360° video camera sensing systems.
Distributed Random Beacon for Blockchain Based on Share Recovery Threshold Signature
Authors: Zhu Yan , Li Bingyu , Yang Yang , Ding Zhenyang , Zheng Haibing , He Guangyu , Hou Shengjie
Published: August 2022

Random beacons play a crucial role in blockchains. Most random beacons in a blockchain are performed in a distributed approach to secure the generation of random numbers. However, blockchain nodes are in an open environment and are vulnerable to adversary reboot attacks. After such an attack, the number of members involved in a random number generation decreases. The random numbers generated by the system become insecure. To solve this problem while guaranteeing fast recovery of capabilities, we designed a threshold signature scheme based on share recovery. A bivariate polynomial was generated among the participants in the distributed key generation phase. While preserving the threshold signature key share, it can also help participants who lost their shares to recover. The same threshold setting for signing and recovery guarantees the security of the system. The results of our scheme show that we take an acceptable time overhead in distributed key generation and simultaneously enrich the share recovery functionality for the threshold signature-based random number generation scheme.
High Resolution On-Road Air Pollution Using a Large Taxi-Based Mobile Sensor Network
Authors: Sun Yuxi , Brimblecombe Peter , Wei Peng , Duan Yusen , Pan Jun , Liu Qizhen , Fu Qingyan , Peng Zhiguang , Xu Shuhong , Wang Ying , Ning Zhi
Published: August 2022

Traffic-related air pollution (TRAP) was monitored using a mobile sensor network on 125 urban taxis in Shanghai (November 2019/December 2020), which provide real-time patterns of air pollution at high spatial resolution. Each device determined concentrations of carbon monoxide (CO), nitrogen dioxide (NO2), and PM2.5, which characterised spatial and temporal patterns of on-road pollutants. A total of 80% road coverage (motorways, trunk, primary, and secondary roads) required 80–100 taxis, but only 25 on trunk roads. Higher CO concentrations were observed in the urban centre, NO2 higher in motorway concentrations, and PM2.5 lower in the west away from the city centre. During the COVID-19 lockdown, concentrations of CO, NO2, and PM2.5 in Shanghai decreased by 32, 31 and 41%, compared with the previous period. Local contribution related to traffic emissions changed slightly before and after COVID-19 restrictions, while changing background contributions relate to seasonal variation. Mobile networks are a real-time tool for air quality monitoring, with high spatial resolution (~200 m) and robust against the loss of individual devices.
Reducing Detrimental Communication Failure Impacts in Microgrids by Using Deep Learning Techniques
Authors: Arbab-Zavar Babak , Sharkh Suleiman M. , Palacios-Garcia Emilio J. , Vasquez Juan C. , Guerrero Josep M.
Published: August 2022

A Microgrid (MG), like any other smart and interoperable power system, requires device-to-device (D2D) communication structures in order to function effectively. This communication system, however, is not immune to intentional or unintentional failures. This paper discusses the effects of communication link failures on MG control and management and proposes solutions based on enhancing message content to mitigate their detritus impact. In order to achieve this goal, generation and consumption forecasting using deep learning (DL) methods at the next time steps is used. The architecture of an energy management system (EMS) and an energy storage system (ESS) that are able to operate in coordination is introduced and evaluated by simulation tests, which show promising results and illustrate the efficacy of the proposed methods. It is important to mention that, in this paper, three dissimilar topics namely MG control/management, DL-based forecasting, and D2D communication architectures are employed and this combination is proven to be capable of achieving the aforesaid objective.
Validity of an iPhone App to Detect Prefrailty and Sarcopenia Syndromes in Community-Dwelling Older Adults: The Protocol for a Diagnostic Accuracy Study
Authors: Montemurro Alessio , Ruiz-Cárdenas Juan D. , Martínez-García María del Mar , Rodríguez-Juan Juan J.
Published: August 2022

Prefrailty and sarcopenia in combination are more predictive of mortality than either condition alone. Early detection of these syndromes determines the prognosis of health-related adverse events since both conditions can be reversed through appropriate interventions. Nowadays, there is a lack of cheap, portable, rapid, and easy-to-use tools for detecting prefrailty and sarcopenia in combination. The aim of this study is to validate an iPhone App to detect prefrailty and sarcopenia syndromes in community-dwelling older adults. A diagnostic test accuracy study will include at least 400 participants aged 60 or over without cognitive impairment and physical disability recruited from elderly social centers of Murcia (Spain). Sit-to-stand muscle power measured through a slow-motion video analysis mobile application will be considered as the index test in combination with muscle mass (calf circumference or upper mid-arm circumference). Frailty syndrome (Fried’s Phenotype) and sarcopenia (EWGSOP2) will both be considered as reference standards. Sensibility, specificity, positive and negative predictive values and likelihood ratios will be calculated as well as the area under the curve of the receiver operating characteristic. This mobile application will add the benefit for screening large populations in short time periods within a field-based setting, where space and technology are often constrained (NCT05148351).
A Norwegian Soul in a Chinese Body? Ethnic Identity and Chinese Adoptees in Norway
Authors: Shang Guowen , Marinaccio Julia Christine , Honne Tuathla Lai
Published: August 2022

The ethnic identity of international adoptees has been a transdisciplinary field of inquiry over the past decades. Taking China-born adopted Norwegian citizens as research subjects, this study uses a mixed-method approach to explore how they perceive their ethnic identity and origin in the host society of Norway. We find that Chinese adoptees mainly identify as racially Chinese but culturally Norwegian, and their Chineseness lies primarily in their appearance. They generally feel secure about their ethnic background despite the challenges and paradoxes caused by their Chinese looks. Most adoptees have no attachment to their birth country, and their interests in China and Chinese culture are usually instrumental and individual-based. Three main socio-cultural factors shape the ethnic identity of China-born adopted children: (1) the negligible impact of their pre-adoptive history upon them, (2) a supportive family environment acknowledging their differences, and (3) an inclusive socio-cultural environment that respects ethnic diversities. No clear tendency towards constructing or enacting double identities among the adoptees was found. Finally, our respondents reported fewer racist experiences than suggested by recent literature on migrants and international adoptees in current literature. This aspect needs further research, also in reference to other cohorts of adoptees.
Sovereign Surfing in the Society of Control: The Parkour Chase in Casino Royale as a Staging of Social Change
Authors: Jonasson Kalle , Eriksson Jonnie
Published: August 2022

In “Postscript on Societies of Control”, French philosopher Gilles Deleuze proclaimed that “Everywhere surfing has replaced the older sports”. By this, he alluded to Foucault’s thoughts on older societal regimes and power diagrams of sovereignty and discipline, and that now such models have been supplemented with governance through control and allegations of increased freedom. This article has as its point of departure the potential of sports to reflect social change. Contemporaneously to the coining of Deleuze’s surfing sentence, a new sport emerges: parkour, in which practitioners “surf” the urban realm. This practice gained attention globally when it was featured in the 2006 James Bond film Casino Royale. The analysis in this article revolves around the different ways of moving in and through the environment in the renowned parkour chase in the beginning of the movie. How do different kinds of displacement in the parkour chase of Casino Royale relate to the transition between the societies described by Deleuze, and what new adaptations emerge and what old logics and models return? It is concluded that the older forms of power prevail and that the ideal of the society of control cannot be realised.
Clientelism, Turnout and Incumbents’ Performance in Chilean Local Government Elections
Authors: Morales Mauricio , Belmar Fabián
Published: August 2022

Parties and their leaders are linked programmatically and non-programmatically with citizens, incentivising the latter to vote in elections and seeking to influence their choices. In this paper, we analyse the effects of politician–voter linkages on the electoral performance of incumbent mayors in Chile and on electoral turnout in their municipalities. To measure the linkages, we use personal meetings that mayors hold with citizens. While some mayors use this mechanism to solve problems of general interest (programmatic meetings), others do so to provide bureaucratic advantages or benefits for their constituents (non-programmatic meetings). We use a database of 44,162 personal meetings aggregated from Chile’s 345 municipalities. We argue that increases in the number of meetings positively impact electoral turnout and increase the chances of success for incumbent mayors when they compete for re-election. This effect is particularly significant in the case of electoral performance and the re-election of mayors in municipalities with high levels of rurality. Finally, we report that the meetings not only help mayors to link with their constituents but also help them to publicise their political work.
Digital Inclusive Finance, Human Capital and Inclusive Green Development—Evidence from China
Authors: Song Junru , Zhou Hongcan , Gao Yanchen , Guan Yongpan
Published: August 2022

To analyze the impact of digital inclusive finance and human capital on inclusive green economic development in China, we build a comprehensive indicator system to measure the level of inclusive green development and use the super-efficiency SBM method to measure the inclusive green total factor productivity (IGTFP) in Chinese cities, then the system GMM model is used to empirically test the direct and interactive influences. Inclusive green development in China has maintained a growing trend in recent years, reaching a peak in 2017. The development of digital inclusive finance in terms of breadth, depth and degree of digitization is conducive to promoting inclusive green development. Although human capital does not directly affect inclusive green development, it plays a significantly positive moderating role in the process of digital inclusive finance promoting inclusive green development. In this paper, the impact of digital inclusive financial and human capital and their interactions on inclusive green development is analyzed within a unified framework, which has important practical significance for the orderly promotion of the development of digital inclusive finance, improving residents’ education level and promoting inclusive green development.
Developing Students’ Attitudes toward Convergence and Creative Problem Solving through Multidisciplinary Education in Korea
Authors: Kim Seong-Won , Lee Youngjun
Published: August 2022

Given the rapid speed at which digital transformation has progressed, social or scientific problems that are difficult to solve using knowledge gained from the existing segmented academic paradigm have emerged. To solve these problems, the need for talent convergence has increased, and Korea has begun to provide convergence education, starting with science, technology, engineering, art, and mathematics (STEAM) education. Convergence education is defined as “education to cultivate knowledge that can solve problems creatively and comprehensively by raising interest and understanding of convergence knowledge, processes, and the nature of various fields related to science and technology”. However, STEAM education faces several difficulties. To overcome these limitations, science, mathematics, and informatics convergence education (SMICE) has been studied, but verifying the effectiveness of SMICE has been difficult. Consequently, this study analyzes the effects of SMICE on middle-school students’ attitudes toward convergence (ATC) and creative problem-solving (CPS) abilities. The subjects of the study were 50 middle-school students who received SMICE and general software (SW) education, and students’ subsequent changes in attitude are analyzed. The results show that students who received SMICE improved their ATC and CPS abilities. In particular, participants’ ATC and CPS scores were higher than those of students who received general SW education. Through this, a multidisciplinary education model is developed focusing on science, mathematics, and informatics, and proves the educational effect of the developed model when applied to classes.
A Proposal to Solve Finite N Matrix Theory: Reduced Model Related to Quantum Cosmology
Authors: López-Picón José Luis , Obregón Octavio , Ríos-Padilla José
Published: August 2022

The SU(N) invariant model of matrix theory that emerges as the regularization of the 11-dimensional super membrane is studied. This matrix model is identified with M theory in the limit N→∞. It has been conjectured that matrix models are also relevant for finite N where several examples and arguments have been given in the literature. By the use of a Dirac-like formulation usually developed in finding solutions in Supersymmetric Quantum Cosmology, we exhibit a method that could solve, in principle, any finite N model. As an example of our procedure, we choose a reduced SU(2) model and also show that this matrix model contains relevant supersymmetric quantum cosmological models as solutions. By these means, our solutions constitute an example in order to consider why the finite N matrix models are also relevant. Since the degrees of freedom of matrix models are, in some limit, identified with those of Super Yang Mills Theory SYM with a finite number of supercharges, our methodology offers the possibility, through some but yet unspecified identification, to relate the quantization presented here with that of SYM theory for any finite N.
Pharmacotherapy and efficacy of antihypoxants and antioxidants
Authors:   FSAEI HE N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Pasenko D. A.
Published: August 2022

In clinical practice, antihypoxants, «deproteinized calf blood hemoderivatives », and an antioxidant, «ethylmethylhydroxypyridine succinate», are used in the treatment of cerebral ischemic stroke and transient attacks. The use of these drugs is pathophysiologically justified as it prevents neuronal damage, which is confirmed by the clinical guidelines «Ischemic Stroke and Transient Ischemic Attack in Adults», 2021. However, these drugs have not been proven effective. The purpose of the work: to study the expected effect of these drugs, based on pharmacodynamics and pharmacokinetics, as well as biochemical and physiological (pathophysiological) capabilities of the body.
Possible pharmacotherapy methods in post-COVID encephalopathy
Authors:   FSAEI HE N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Rakhmankulov D. V.
Published: August 2022

Recently, there has been great interest in studying the complications of the novel coronavirus infection COVID-19 in the form of the so-called post-COVID syndrome (long COVID — U09.9). One of the main manifestations of this syndrome is encephalopathy, occurring due to disorders in microcirculation and functioning of the neuronal network, pathways, and synaptic apparatus at the cortical, subcortical and stem levels caused by direct viral invasion, as well as non-specific reactions of cerebral structures to ischemia, hypoxia and viral invasion, determined by the degree of compensatory mechanisms. The purpose of this work is to select possible methods of treating this complication using pharmacotherapy. The tasks are: to study the pathogenesis of this complication; to research literature on the subject of morphological macro- and micro-changes; to review existing treatments; to conduct a study with a control group and analyze the data obtained.
Comparative analysis of C-section outcomes with antibiotic prophylaxis and antibiotic therapy in the Regional Perinatal Center
Authors:   FSAEI HE Kazan (Volga Region) Federal University, Kazan, Russia, Tashtanbekova Ch. B. , E. G. Aleksandrova E. G. Aleksandrova ,   FSAEI HE Kazan (Volga Region) Federal University, Kazan, Russia, Evstratov A. A. ,   SAHI Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Kazan, Russia, Chuenkova E. A. ,   SAHI Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Kazan, Russia, Ziganshina L. E. ,   FSBEI FPE Russian Medical Academy of Continuous Professional Education, Moscow, Russia; FSAEI HE Peoples' Friendship University of Russia, Moscow, Russia; FSBEI HE Kazan State Medical University, Kazan, Russia
Published: August 2022

Prophylactic prescription of antibiotics before C-section prevents maternal infectious morbidity in the postoperative period, while irrational prescription leads to the development of adverse outcomes [1]. Postpartum infections are becoming the main cause of prolonged hospital stay and increase the costs of the healthcare system [2]. The aim: to conduct a comparative pharmacoepidemiological analysis of the caesarean section outcomes with antibiotic prophylaxis and antibiotic therapy.
Pharmacoepidemiological analysis of antibiotic therapy for pathologies in women during pregnancy
Authors:   Andijan State Medical Institute, Andijan, Uzbekistan, Eshonkhuzhaev O.O. , Usmanova F.T. ,   Andijan State Medical Institute, Andijan, Uzbekistan
Published: August 2022

The aim of the work was to assess the quality of antibiotic therapy for pathologies in women during pregnancy. Materials and methods: Retrospective analysis of case histories of pregnant women who received antibiotic therapy (ABT) in one of the maternity complexes in the Andijan Region.
Economical aspects of rice production in Russia: scientific argumentation toward sustainable development
Authors: Mikhailenko A. V. , Ruban D. A.
Published: August 2022

Sustainable development of rice production in Russia requires serious scientific argumentation from the economical point of view. The analysis of journal articles of domestic specialists devoted to rice production economy reveals their relatively high number (44 works during 5 years) and diversity (11 themes attributed to 3 thematic clusters). The geographical distribution of these articles is highly uneven, and the majority of them are linked by focus and authors’ affiliation to the Krasnodar Region. Meantime, several regions developing rice production (also very successfully) lack the relevant articles. Many articles bear limited citations of sources, and the use of fresh international information is minimal. The results indicate on the interest of Russian specialists to the economical aspects of rice production, although the current state of the related scientific argumentation is a kind of challenge to sustainability of this direction of crop production, and this requires implementation of special research initiatives.
PENGGUNAAN BUKU PAKET UNTUK MEMPERMUDAH PROSES PEMBELAJARAN SISWA DI SMP NEGERI 2 KAMPAR
Authors:   Universitas Riau, Rohani Rohani , Nurmalia Nurmalia , Juragan Rezky Sihombing Pirma , Armiati Armiati ,   SMP Negeri 2 Kampar, Srikartikowati Srikartikowati ,   Universitas Riau
Published: August 2022

The textbook is a student learning resource with several uses that can simplify the learning process. With textbooks, students can learn more actively in class, students can also repeat lessons from books when they are brought home. Likewise, the teacher can expand the subject matter based on the information contained in it. This paper aims to find ideas on how to use textbooks to facilitate the learning process. To achieve the objective of the observation, the data were obtained using participatory techniques, in-depth interviews, documentation and Focus Group Discussions. Furthermore, the data obtained were analyzed descriptively, namely by providing an explanation of the findings obtained. The research yielded information on the use of textbooks as learning resources for students, textbooks as learning media and increasing students' learning motivation. At SMP Negeri 2 Kampar the use of textbooks was not optimal due to the lack of quotas for textbooks at school, and the lack of quality textbooks given to students. students like there are scribbles and tears.
TANTANGAN IMPLEMENTASI MODEL PEMBELAJARAN BLANDED LEARNING DI SMP NEGERI 1 DAYUN MASA PANDEMIK COVID-19
Authors:   Universitas Riau, Asril Asril , Malina Nainggolan Tiur , Dwi Kurniawan Robi , Sawitri Isma , Muktianis Nita
Published: August 2022

Education is one of the leading factors in advancing a nation. The implementation of education in the midst of the COVID-19 pandemic, has been running with innovations from the government on the learning model applied in schools. We know this model as a bold, captivating and combined learning system. In connection with the above explanation, we will try to identify what challenges will be faced by SMPN 1 Dayun in implementing the Blended Learning model during the covid-19 pandemic. This study uses a descriptive qualitative method, where in obtaining information and data we use survey techniques, observations, and interviews with the school. The subjects in this study were all 7th grade students of SMP Negeri 1 Dayun for the 2020/2021 academic year. The results showed that SMPN 1 Dayun was considered successful in implementing the Learning Method even though it had to face various obstacles and obstacles in its implementation.
Upaya Meningkatkan Hasil Belajar Matematika Melalui Pendekatan CBSA Pada Peserta Didik Kelas V.A SDN 18 Lembah Melintang
Authors:   SDN 18 Lembah Melintang, Arjuni Arjuni
Published: August 2022

The problems to be examined in this study is: Does the use of CBSA approach can improve learning outcomes V.A grade math students of SDN 18 Valley Crossing? The purpose of this action research was to determine the learning outcome approach mathematics through the use of CBSA learners V.A grade SDN 18 Valley Crossing This study uses classroom action research as much as two rounds. Each round consists of four phases: planning, implementation, observation and reflection. Goal of this research is V.A grade students of SDN 18 Valley Crossing. The data obtained are kualitatif.Dari quantitative data and analysis results can be seen which approach CBSA have a positive impact in improving the learning outcomes of students characterized by increased completeness of learners in each cycle, ie pre-cycle (52.63%), the first cycle (73.68 %), the second cycle (86.84%).
Upaya Meningkatkan Hasil Belajar Bahasa Indonesia Melalui Metode Pembelajaran Tanya Jawab (Questions Answer) pada Siswa Kelas VI SDN 26 Sungai Limau
Authors:   SDN 26 Sungai Limau, Hayati Hayati
Published: August 2022

Question and answer method is a way of presenting a lesson in the form of questions to be answered, especially from teachers to students, but can also be from student to teacher. The problems to be examined in this study is: Does the use of learning methods FAQ (Questions and answers) can improve learning outcomes Indonesian students Class VI SDN 26 Sungai Limau? The purpose of this action research is to improve learning outcomes Indonesian through the use of learning methods FAQ (Questions and answers) on a class VI student of SDN 26 Sungai Limau.Penelitian using action research as much as two rounds. Each round consists of four phases: planning, implementation, observation and reflection. Goal of this research is a Class VI student of SDN 26 Sungai Limau. The data obtained are quantitative data and analysis results kualitatif.Dari learning methods FAQ (Questions and answers) had a positive impact in improving student learning outcomes characterized by increased mastery learning students in each cycle, the first cycle (66.67%), the second cycle ( 87.88%). the conclusion of this study is the learning method FAQ (Questions and answers) have a positive effect, which can increase student learning outcomes are indicated with an average response of students stating that the student interested and are interested in learning methods FAQ (Questions and answers ) so that they become motivated to learn.
Upaya Peningkatan Kemampuan Pembelajaran Guru Sekolah Menengah Kejuruan Melalui Diskusi Panel Pada Kelompok Musyawarah Guru Mata Pelajaran (MGMP) Di SMK N 1 Gunung Tuleh
Authors:   SMK N 1 Gunung Tuleh, Zulpan Zulpan
Published: August 2022

Based on observations that have researchers do To teachers at SMK N 1 Mount Tuleh, it was found that the learning ability of teachers remains low. The purpose of this study was to Improve Learning Ability teacher diSMK N 1 Mount Tuleh. This research is a school action. The procedure in this research include planning, action, observation and reflection. The study consisted of two cycles of the four meetings. Subject of the study consisted of three teachers from SMK N 1 Mount Tuleh. Data were collected by using observation sheet. Data were analyzed using percentages. The results showed that the panel discussion at the Consultative Group Subject teachers can improve learning ability of teachers at SMK N 1 Mount Tuleh. This is evidenced by the increase in the learning capability of teachers from the first cycle to the second cycle. On average ability learning ability of teachers in the first cycle was 40.33 with less category and the second cycle is 83.33 with both categories.
Upaya Meningkatkan Minat Belajar Peserta Didik Dalam Pembelajaran Penjaskes Melalui Penerapan Metode Pembelajaran Demonstrasi Di Kelas V SDN 18 Lembah Melintang
Authors:   SDN 18 Lembah Melintang, Yusliana Yusliana
Published: August 2022

Based on the learning process of students in class V SDN 18 Valley Crossing in teaching PE found that the interest of students in learning PE is still very low. The purpose of this study is to describe and obtain information about the efforts to increase the interest of learners in learning PE through the application of learning methods in the classroom demonstration of SDN 18 Valley Crossing Barat.Penelitian Pasaman of this is a class action. The procedure in this research include planning, action, and reflection obeserVsi. The study consisted of two cycles of the four meetings. Subject of the study consisted of 25 students in class V SDN 18 Valley Crossing. Data were collected by using observation sheet. Data were analyzed using persentase.Berdasarkan research and discussion that has been presented in the previous chapter, it can be concluded that it can be concluded that the model pembelajaan demonstration can increase the interest of learners in the learning of PE at SDN 18 Valley Crossing. Interests of learners from the first cycle to the second cycle. Interest of learners in the first cycle was 70.66 (enough) increased to 81.66 (good) with an increase of 11.00.
Fuzzy Logic untuk Menentukan Status Gizi Pada Rumah Sakit M. Zein Painan-Pessel
Authors:   STKIP Pesisir Selatan, Anita Fitri
Published: August 2022

Human life is crowded and busy often make a person forget the health and forget to pay attention to the nutrients in the food consumed . While in a healthy body can be judged from the meet nutrient needs. It can simply be described the sense of nutritional intake is all the body needs to be healthy , which is obtained from the nutritional intake of foods containing carbohydrates , protein , fat , vitamins and nutritional mineral.Pemenuhan balanced according to the condition of the body in order to meet health standards sometimes be an obstacle to set nutrition impartial. Therefore, this system created in order to help some parties such as nutritionists hospital, the governing party of nutrition of the patient, and so by applying fuzzy logic ( FL ) that helps provide provisions necessary criteria to identify the age , height , and weight body. By doing the calorie calculation method of fuzzy logic ( FL ) is expected to produce the right decisions about nutrition intake for the patient .
Peningkatan Kemampuan Guru Dalam Menyusun Kelengkapan Mengajar Melalui In-House Training Di SMPN 4 Pasaman
Authors:   SMPN 4 Pasaman, Dasman Dasman
Published: August 2022

Based on the observations that have been researchers did To the Teacher in SMP N 4 Pasaman, it was found that the ability of Master in Teaching Completeness Preparing still low. The purpose of this research is to improve the ability of Teacher In Teaching Through Completeness Develop In-House Training at SMP N 4 Pasaman .Penelitian a school action research. The procedure in this research include planning, action, observation and reflection. The study consisted of two cycles of the four meetings. Subjects consisted of 9 people Master SMP Negeri 4 Pasaman. Data were collected by using observation sheet. Data were analyzed using persentase.Hasil research shows that through In-House Training can improve Capability Teachers Teaching In Developing Completeness. This is evidenced by the increased ability Completeness Develop Teaching Teachers In the first cycle to the second cycle. On average ability skills of teachers in the Teacher In Capabilities Establish Teaching Completed in the first cycle was 49.33 with less category and the second cycle is 83.66 with both categories.
Peran Kerja Nyata Pengawas Sekolah Terhadap Kinerja Guru Pendidikan Agama Islam Dalam Kegiatan Belajar Mengajar KBM Di SDN 18 Luhak Nan Duo
Authors:   SDN 18 Luhak Nan Duo, Aisyah Siti
Published: August 2022

Based on the observations that have been researchers did Kepada Guru in SD 18 Luhak Nan Duo, found that teacher performance PAI in KBM still low. The purpose of this study is to Improve Teacher Performance PAI in KBM in SD 18 Luhak Nan Duo. This research is a school action. The procedure in this research include planning, action, observation and reflection. The study consisted of two cycles of the four meetings. Subjects consisted of 3 people Master PAI SD 18 Luhak Nan Duo. Data were collected by using observation sheet. Data were analyzed using percentages. The results showed that the role of the real work of school inspectors can improve teacher performance PAI in KBM in SD 18 Luhak Nan Duo. This is evidenced by the increase in PAI Teacher Performance in KBM from the first cycle to the second cycle. Average Teacher Performance PAI ability in teaching in the first cycle was 49.66 with less category and the second cycle is 82.33 with both categories.
PENINGKATAN KEMAMPUAN GURU DALAM MENYUSUN PROPOSAL PENELITIAN TINDAKAN KELAS MELALUI MODEL PEMBINAAN CLCK (CONTOH, LATIHAN, CONTROL, KERJA MANDIRI) BERBASIS PENDAMPINGAN INTENSIF DI
Authors:   SMKN 1 PASAMAN, SUPANRI EDI
Published: August 2022

Based on observations of the competencies of teachers at Pasaman 1 Vocational School in preparing Classroom Action Research Proposals, it was found that the teacher's ability to compile classroom action research was still low. The purpose of this study is to describe and obtain information about improving the ability of teachers in preparing Class Action Research Proposals through the CLCK development model (Example, Exercise, Control, Independent Work) Based on Intensive Assistance Based at SMK 1 Pasaman. This research is a school action research. Research procedures in this study include planning, action, observation and reflection. This research consisted of two cycles with four meetings. The research subjects consisted of 5 teachers of Pasaman 1 SMKN. Research data were collected using observation sheets. Data were analyzed using percentages. Based on the results of research and discussion, it can be concluded that the CLCK development model based on Intensive Assistance can improve the ability of teachers in preparing Classroom Action Research Proposals at SMK 1 Pasaman. Analysis of the quality of PTK proposals made by teachers shows that the teacher's ability to prepare the Classroom Action Research Proposal increases from cycle I to cycle II. The ability of teachers in compiling Classroom Action Research Proposals in cycle I was 71.50 (sufficient) increased to 93.00 (good) in cycle II