bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL
Authors: Zhou Zheng-Jun , Dai Zhi , Zhou Shao-Lai , Hu Zhi-Qiang , Chen Qing , Zhao Yi-Ming , Shi Ying-Hong , Gao Qiang , Wu Wei-Zhong , Qiu Shuang-Jian , Zhou Jian , Fan Jia
Published: March 2023

PDF file - 110K, Supplementary Figure S2. The effect of hnRNPAB on tumor growth and metastasis in vivo.
Suppl Material & Suppl. Table S1 from Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors
Authors: Rani Sweta , Corcoran Claire , Shiels Liam , Germano Serena , Breslin Susan , Madden Stephen , McDermott Martina S. , Browne Brigid C. , O'Donovan Norma , Crown John , Gogarty Martina , Byrne Annette T. , O'Driscoll Lorraine
Published: March 2023

Suppl Material & Suppl. Table S1
Supplementary Figure 2 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: March 2023

PDF file - 248K, Knockdown of endogenous deltaNp63 in JHU-011.
Supplementary Methods from Caveolin-1–LRP6 Signaling Module Stimulates Aerobic Glycolysis in Prostate Cancer
Authors: Tahir Salahaldin A. , Yang Guang , Goltsov Alexei , Song Ki-Duk , Ren Chengzhen , Wang Jianxiang , Chang Wenjun , Thompson Timothy C.
Published: March 2023

PDF file - 46K, Construction of LRP6-Flag plasmid.
Supplementary Figure 2 from Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer
Authors: Feigin Michael E. , Akshinthala S. Dipikaa , Araki Kiyomi , Rosenberg Avi Z. , Muthuswamy Lakshmi B. , Martin Bernard , Lehmann Brian D. , Berman Hal K. , Pietenpol Jennifer A. , Cardiff Robert D. , Muthuswamy Senthil K.
Published: March 2023

PDF file - 187K, H&E staining of hyperplasia and tumors from hSCRIBP305L mice.
Supplementary Figure 2 from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: March 2023

PDF file - 727K, Dideoxynucleotide sequencing confirmed the presence of NRF2, CUL3, and SIRT1 mutations in case samples
Supplementary Figure 1 from HLA-Restricted CTL That Are Specific for the Immune Checkpoint Ligand PD-L1 Occur with High Frequency in Cancer Patients
Authors: Munir Shamaila , Andersen Gitte Holmen , Met Özcan , Donia Marco , Frøsig Thomas Mørch , Larsen Stine Kiaer , Klausen Tobias Wirenfeldt , Svane Inge Marie , Andersen Mads Hald
Published: March 2023

PDF file - 39K, Correlation between PD-1 or PD-L1 expression and the presence of specific T-cell reactivity towards PD-L1
Supplementary Figure 5 from NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Authors: Gregg Jennifer L. , Turner Robert M. , Chang Guimin , Joshi Disha , Zhan Ye , Chen Li , Maranchie Jodi K.
Published: March 2023

PDF file - 114K, Supplemental Figure 5 Cellular distribution of HIF-2alpha under normal oxygen conditions. (a) Representative confocal microscopy images (magnification 400x) showing HIF-2α or Nox4 immunofluorescense, DAPI nuclear staining, or merged images. b) Control (NS) or Nox4 shRNA (KD) cells were imaged following exposure to TEMPOL (0.25 mM), DTT (1mM). c) 786-0 NS cells imaged following transduction with Ad-GFP or Ad-MnSOD. d) 786-0 cells expressing pcDNA-Nox4 imaged with or without treatment with TEMPOL (0.25 mM).
Supplementary Figure 1 from NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Authors: Gregg Jennifer L. , Turner Robert M. , Chang Guimin , Joshi Disha , Zhan Ye , Chen Li , Maranchie Jodi K.
Published: March 2023

PDF file - 224K, Supplemental Figure 1. Quantitative RT-PCR (a) and semi-quantitative RT-PCR (b) for detection of Nox1 in 786-0, RCC4 or LNCaP prostate cancer cells using two published primer pairs(14, 17),. Error bar represents +/- SE.
Supplementary Figure 1 from Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells
Authors: Kozono Shingo , Ohuchida Kenoki , Eguchi Daiki , Ikenaga Naoki , Fujiwara Kenji , Cui Lin , Mizumoto Kazuhiro , Tanaka Masao
Published: March 2023

PDF file - 141K, Supplementary Figure 1: A and B. Expression analysis of α-SMA, glial fibrillary acidic protein (GFAP), and cytokeratin 19 in human PSCs isolated from pancreatic ductal adenocarcinoma.
Supplementary Table 1 from USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression
Authors: Schrecengost Randy S. , Dean Jeffry L. , Goodwin Jonathan F. , Schiewer Matthew J. , Urban Mark W. , Stanek Timothy J. , Sussman Robyn T. , Hicks Jessica L. , Birbe Ruth C. , Draganova-Tacheva Rossitza A. , Visakorpi Tapio , DeMarzo Angelo M. , McMahon Steven B. , Knudsen Karen E.
Published: March 2023

PDF file - 50K, Primer sequences used in manuscript.
Supplementary Table 1 from Endocrine Fibroblast Growth Factor FGF19 Promotes Prostate Cancer Progression
Authors: Feng Shu , Dakhova Olga , Creighton Chad J. , Ittmann Michael
Published: March 2023

PDF file - 42KB, Primers used for quantitative RT-PCR and conventional RT-PCR.
Supplementary Figure 7 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: March 2023

PDF file - 1142K, Fig S7. Treatment with AS101 prevents MRD in a xenograft mouse model of AML.
Supplementary Figure 4 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: March 2023

PDF file - 1318K, Fig S4. DTNB or AS101 sensitize high VLA-4 expressing lekemic cells from AML patients, to chemotherapy.
Supplementary Figure 3 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: March 2023

PDF file - 718K, Fig. S3: The VLA-4 integrin activity on AML cells can be directly affected by AS101 by redox rearrangements of vicinal thiols within the cysteine-rich domain of the integrin resulting in physiologic consequences.
Supplementary Figure 3 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: March 2023

PDF file - 457K, Circadian gene expression patterns in liver and colon mucosa according to chronotoxicity Class.
Supplementary Figure 2 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: March 2023

PDF file - 173K, Body weight loss as a function of irinotecan circadian timing in male or female mice from three mouse strains.
Supplementary Table 1 from Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1α in Breast Cancer
Authors: Zhou Zhuan , Liu Fangfang , Zhang Zhi-Song , Shu Feifei , Zheng Yangyang , Fu Li , Li Lu-Yuan
Published: March 2023

PDF file - 93KB, RHBDF1 expression and clinicopathological features of invasive breast cancer (IBC).
Supplementary Figures 1 - 4 from Targeting XRCC1 Deficiency in Breast Cancer for Personalized Therapy
Authors: Sultana Rebeka , Abdel-Fatah Tarek , Abbotts Rachel , Hawkes Claire , Albarakati Nada , Seedhouse Claire , Ball Graham , Chan Stephen , Rakha Emad A. , Ellis Ian O. , Madhusudan Srinivasan
Published: March 2023

PDF file - 322K, Supplemental Figure 1. Disease free survival (DFS) and distant metastasis free survival (DMFS) in breast cancer whole cohort (A), Lymph node negative (B) and lymphnode positive (C). Supplemental Figure 2. Disease free survival (DFS) and distant metastasis free survival (DMFS) in breast cancerlow risk, no adjuvant therapy (A), high risk, received endocrine therapy (B) and high risk, received CMF chemotherapy (C). Supplemental Figure 3. Disease free survival (DFS) and distant metastasis free survival (DMFS) in breast cancerER negative tumours (A), Triple negative tumours (B). Supplemental Figure 4. Clonogenic survival assay (A), Annexin-V FITC assay (B).
Supplementary Table 1 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: March 2023

PDF file - 382K, Peptide description. ID and sequence in single letter amino acid code of each peptide is shown
Supplementary Movie 1 from A Chimeric Receptor with NKG2D Specificity Enhances Natural Killer Cell Activation and Killing of Tumor Cells
Authors: Chang Yu-Hsiang , Connolly John , Shimasaki Noriko , Mimura Kousaku , Kono Koji , Campana Dario
Published: March 2023

WMV file - 3260K, Live cell confocal photography of mock- (left panel) and NKG2D-DAP10-CD3ξ-transduced NK cells (right panel) co-cultured U2 OS osteosarcoma cells. NK cells were labeled with PKH26 (Sigma) before culture and appear red. Microscopy was performed with a Nikon TE2000E2 microscope equipped with a Nikon C1Si confocal using 488nm and 561nm DPSS lasers for excitation. Temperature was maintained at 37oC and CO2 at 5% using an environmental control chamber. Images were acquired with a Nikon 40x 1.3 NA DIC objective every 30s for 2hr using Nikon EZC1 software. Imaris (Bitplane Scientific Software) was used to analyze speed and displacement of NK cells.
Supplementary Tables 1 - 2 from Phenotypic Profiling of DPYD Variations Relevant to 5-Fluorouracil Sensitivity Using Real-time Cellular Analysis and In Vitro Measurement of Enzyme Activity
Authors: Offer Steven M. , Wegner Natalie J. , Fossum Croix , Wang Kangsheng , Diasio Robert B.
Published: March 2023

PDF file - 74K, Supplementary Tables: 1. Primers used for site directed mutagenesis of DPYD expression plasmids. 2. Primers used for sequencing of DPYD expression plasmids.
Supplementary Figure 7 from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: March 2023

PDF file - 77K, Intracellular staining of IL-23p19, IL-12p40 and TNF in GM-CSF derived BMDCs stimulated with various agonists.
Supplementary Figure 5 from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: March 2023

PDF file - 101K, Only in vitro stimulated GM-CSF-derived BMDCs produce IL-23.
Supplementary Figure 4 from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: March 2023

PDF file - 76K, Time course of cytokine production by GM-BMDCs after stimulation.
Supplementary Figure Legends from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Authors: Chow Kin-Hoe , Shin Dong-Mi , Jenkins Molly H. , Miller Emily E. , Shih David J. , Choi Seungbum , Low Benjamin E. , Philip Vivek , Rybinski Brad , Bronson Roderick T. , Taylor Michael D. , Yun Kyuson
Published: March 2023

Supplementary Figure Legends from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary Movie 7 from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

MOV file - 2626K, Motility S2-013.M.3A
Supplementary Figure 4 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Authors: Chow Kin-Hoe , Shin Dong-Mi , Jenkins Molly H. , Miller Emily E. , Shih David J. , Choi Seungbum , Low Benjamin E. , Philip Vivek , Rybinski Brad , Bronson Roderick T. , Taylor Michael D. , Yun Kyuson
Published: March 2023

FISH results from Ptch tumors that progressed to the GFI subtype during in vivo passaging.
Supplementary Movie 6 from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

MOV file - 2609K, Motility S2-013.M.1A
Supplementary Movie 5 from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

MOV file - 2607K, Motility S2-013.M1F
Supplementary Movie 4 from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

MOV file - 2609K, Motility S2-013.4A
Supplemental Figure Legends from Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
Authors: Fiskus Warren , Saba Nakhle , Shen Min , Ghias Mondana , Liu Jinyun , Gupta Soumyasri Das , Chauhan Lata , Rao Rekha , Gunewardena Sumedha , Schorno Kevin , Austin Christopher P. , Maddocks Kami , Byrd John , Melnick Ari , Huang Peng , Wiestner Adrian , Bhalla Kapil N.
Published: March 2023

Figure Legends for the Supplemental Data.
Supplementary Figure 1 from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

PDF file - 209K, Graphic representation of mp120 constructs used in this study. (A) Full-length, N-terminal and C terminal deleted mp 120. (B) ARM domain deleted mp120. Each of the 10 ARM domains was deleted individually by mutagenesis, and were designated mp120 deltaARM 1-10.
Supplementary Methods, Figure Legend, Table 1 from CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression
Authors: Wang Yunshan , Wen Mingxin , Kwon Yongwon , Xu Yangyang , Liu Yueyong , Zhang Pengju , He Xiuquan , Wang Qin , Huang Yurong , Jen Kuang-Yu , LaBarge Mark A. , You Liang , Kogan Scott C. , Gray Joe W. , Mao Jian-Hua , Wei Guangwei
Published: March 2023

PDF file - 306K, Supplemental Table 1. List of genes significantly differentially expressed after CUL4A overexpression.
Supplementary Figure 5 from CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression
Authors: Wang Yunshan , Wen Mingxin , Kwon Yongwon , Xu Yangyang , Liu Yueyong , Zhang Pengju , He Xiuquan , Wang Qin , Huang Yurong , Jen Kuang-Yu , LaBarge Mark A. , You Liang , Kogan Scott C. , Gray Joe W. , Mao Jian-Hua , Wei Guangwei
Published: March 2023

PDF file - 176K, Supplemental Figure 5. CUL4A regulates ZEB1 transcriptional expression through H3K4 trimethylation.
Data Supplement from ADAM9 Promotes Lung Cancer Metastases to Brain by a Plasminogen Activator-Based Pathway
Authors: Lin Chen-Yuan , Chen Hung-Jen , Huang Cheng-Chung , Lai Liang-Chuan , Lu Tzu-Pin , Tseng Guan-Chin , Kuo Ting-Ting , Kuok Qian-Yu , Hsu Jennifer L. , Sung Shian-Ying , Hung Mien-Chie , Sher Yuh-Pyng
Published: March 2023

Supplementary Figure S3. Investigation of the role of ADAM9 and CDCP1 in an anchorage-free culture system.
Data Supplement from ADAM9 Promotes Lung Cancer Metastases to Brain by a Plasminogen Activator-Based Pathway
Authors: Lin Chen-Yuan , Chen Hung-Jen , Huang Cheng-Chung , Lai Liang-Chuan , Lu Tzu-Pin , Tseng Guan-Chin , Kuo Ting-Ting , Kuok Qian-Yu , Hsu Jennifer L. , Sung Shian-Ying , Hung Mien-Chie , Sher Yuh-Pyng
Published: March 2023

Supplementary Figure S4. The tPA activity correlates with conversion of full-length CDCP1 to the cleavage form.
Data Supplement from ADAM9 Promotes Lung Cancer Metastases to Brain by a Plasminogen Activator-Based Pathway
Authors: Lin Chen-Yuan , Chen Hung-Jen , Huang Cheng-Chung , Lai Liang-Chuan , Lu Tzu-Pin , Tseng Guan-Chin , Kuo Ting-Ting , Kuok Qian-Yu , Hsu Jennifer L. , Sung Shian-Ying , Hung Mien-Chie , Sher Yuh-Pyng
Published: March 2023

Supplementary Table and Figure Legends. Legend for Supplementary Table S1 and Supplementary Figures S1-S4.
Supplementary Figure 3 from MYC Synergizes with Activated BRAFV600E in Mouse Lung Tumor Development by Suppressing Senescence
Authors: Tabor Vedrana , Bocci Matteo , Alikhani Nyosha , Kuiper Raoul , Larsson Lars-Gunnar
Published: March 2023

PDF file - 1861K, Lung weights of BRAF/MYC mice early in disease.
Supplementary Figure 1 from MYC Synergizes with Activated BRAFV600E in Mouse Lung Tumor Development by Suppressing Senescence
Authors: Tabor Vedrana , Bocci Matteo , Alikhani Nyosha , Kuiper Raoul , Larsson Lars-Gunnar
Published: March 2023

PDF file - 6250K, Activation of BRAFV600E and MYC by Ad-Cre and TAM results in development of SPC-expressing lung tumors. Genomic status after Cre-mediated recombination, MycER protein expression, mouse lung to body weight and expression of differentiation antigens.
Supplementary Tables 1 - 11 from Immune Escape and Survival Mechanisms in Circulating Tumor Cells of Colorectal Cancer
Authors: Steinert Gunnar , Schölch Sebastian , Niemietz Thomas , Iwata Naoki , García Sebastián A. , Behrens Bianca , Voigt Anita , Kloor Matthias , Benner Axel , Bork Ulrich , Rahbari Nuh N. , Büchler Markus W. , Stoecklein Nikolas H. , Weitz Jürgen , Koch Moritz
Published: March 2023

PDF file - 96KB, Summary of patient characteristics and number of chromosomal aberrations determined by aCGH analyses (S1); Summary of the full genomic analyses of CRC derived CTC and the corresponding tumor tissue (S2); UICC stages of the patients enrolled in the mutational analysis (S3); Characteristics of the patients enrolled in the CTC transcriptional analysis (S4); Distribution of sex and UICC stage in patients enrolled in the CTC transcriptional analysis (S5); Summary of patient characteristics and source of CTC isolation for the CTC transcriptional analysis (S6); Clinical information regarding patients enrolled in the CTC mutational analysis (S7); Overview of the real-time PCR primer sequences used in the CTC transcriptional analysis (S8); Overview of the pre-amplification PCR primer sequences used for the mutational profiling of patient-derived CTC and tumor tissue (S9); Summary of the primer sequences used for sequencing analyses and detection of common CRC mutation (S10); Summary of the primer sequences used for noncoding and coding MSI analyses (S11).
Supplementary Figure 5 from Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway
Authors: Martín-Pérez Rosa , Palacios Carmen , Yerbes Rosario , Cano-González Ana , Iglesias-Serret Daniel , Gil Joan , Reginato Mauricio J. , López-Rivas Abelardo
Published: March 2023

PDF file - 42KB, Tunicamycin induces a TRAIL-R2 and caspase-8-dependent apoptotic pathway in NeuT cells.
Supplementary Figure 3 from Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway
Authors: Martín-Pérez Rosa , Palacios Carmen , Yerbes Rosario , Cano-González Ana , Iglesias-Serret Daniel , Gil Joan , Reginato Mauricio J. , López-Rivas Abelardo
Published: March 2023

PDF file - 81KB, Noxa and Bim-independent apoptosis upon ER stress in NeuT cells.
Supplemental data from EGFR Activation and Signaling in Cancer Cells Are Enhanced by the Membrane-Bound Metalloprotease MT4-MMP
Authors: Paye Alexandra , Truong Alice , Yip Cassandre , Cimino Jonathan , Blacher Silvia , Munaut Carine , Cataldo Didier , Foidart Jean Michel , Maquoi Erik , Collignon Joelle , Delvenne Philippe , Jerusalem Guy , Noel Agnès , Sounni Nor Eddine
Published: March 2023

Supplemental data files 2 figures including figure S1 related to figure 4 and Figure S2 related to Figure 5 and Figure 6 and detailed supplemental experimental procedures for methods referred in material and method section including RT-PCR analysis and western blot analysis, inmunohistochemistry, co-immunoprecipitation, immunofluorescence and in vitro 3-dimensional proliferation assay and DNA quantification experiments.
Supplementary Table 3 from Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive Neuroblastoma
Authors: Barbieri Eveline , De Preter Katleen , Capasso Mario , Chen Zaowen , Hsu Danielle M. , Tonini Gian Paolo , Lefever Steve , Hicks John , Versteeg Rogier , Pession Andrea , Speleman Frank , Kim Eugene S. , Shohet Jason M.
Published: March 2023

XLSX file - 14K, Kegg, Biocarta and Oncogenic Pathways GSEA analysis.
Supplementary Figures 1 and 2 and Supplementary Methods from A Preclinical Model of CD38-Pretargeted Radioimmunotherapy for Plasma Cell Malignancies
Authors: Green Damian J. , Orgun Nural N. , Jones Jon C. , Hylarides Mark D. , Pagel John M. , Hamlin Donald K. , Wilbur D.S. , Lin Yukang , Fisher Darrell R. , Kenoyer Aimee L. , Frayo Shani L. , Gopal Ajay K. , Orozco Johnnie J. , Gooley Theodore A. , Wood Brent L. , Bensinger William I. , Press Oliver W.
Published: March 2023

PDF - 156K, Supplementary Figure 1, demonstrating CD38 receptor surface stability. Supplementary Figure 2, demonstrating animal body weight following anti-CD38 pretargeted radioimmunotherapy. Supplemental methods describing fusion protein construction as well as endocytosis and trichloroacetic acid (TCA) precipitation assays.
Supplementary Figure Legend from Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive Neuroblastoma
Authors: Barbieri Eveline , De Preter Katleen , Capasso Mario , Chen Zaowen , Hsu Danielle M. , Tonini Gian Paolo , Lefever Steve , Hicks John , Versteeg Rogier , Pession Andrea , Speleman Frank , Kim Eugene S. , Shohet Jason M.
Published: March 2023

PDF file - 29K
Supplementary Figure 2 from p16INK4a Impairs Homologous Recombination–Mediated DNA Repair in Human Papillomavirus–Positive Head and Neck Tumors
Authors: Dok Rüveyda , Kalev Peter , Van Limbergen Evert Jan , Asbagh Layka Abbasi , Vázquez Iria , Hauben Esther , Sablina Anna , Nuyts Sandra
Published: March 2023

PDF file - 72KB, Characterization of the efficacy of CDK4/6 inhibition by PD0332991.
Supplementary Figure 4 from Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive Neuroblastoma
Authors: Barbieri Eveline , De Preter Katleen , Capasso Mario , Chen Zaowen , Hsu Danielle M. , Tonini Gian Paolo , Lefever Steve , Hicks John , Versteeg Rogier , Pession Andrea , Speleman Frank , Kim Eugene S. , Shohet Jason M.
Published: March 2023

PDF file - 45K, Xenografts tumor growth is proportional to CHAF1A protein levels.
Supplementary Methods from p53-Induced miR-15a/16-1 and AP4 Form a Double-Negative Feedback Loop to Regulate Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Shi Lei , Jackstadt Rene , Siemens Helge , Li Huihui , Kirchner Thomas , Hermeking Heiko
Published: March 2023

PDF file - 52K
Supplementary Table 1 from Unbiased Compound Screening Identifies Unexpected Drug Sensitivities and Novel Treatment Options for Gastrointestinal Stromal Tumors
Authors: Boichuk Sergei , Lee Derek J. , Mehalek Keith R. , Makielski Kathleen R. , Wozniak Agnieszka , Seneviratne Danushka S. , Korzeniewski Nina , Cuevas Rolando , Parry Joshua A. , Brown Matthew F. , Zewe James , Taguchi Takahiro , Kuan Shin-Fan , Schöffski Patrick , Debiec-Rychter Maria , Duensing Anette
Published: March 2023

PDF - 63K, Response of GIST and LMS cells to 89 FDA-approved anti-cancer compounds.
Supplementary Figure 3 from Unbiased Compound Screening Identifies Unexpected Drug Sensitivities and Novel Treatment Options for Gastrointestinal Stromal Tumors
Authors: Boichuk Sergei , Lee Derek J. , Mehalek Keith R. , Makielski Kathleen R. , Wozniak Agnieszka , Seneviratne Danushka S. , Korzeniewski Nina , Cuevas Rolando , Parry Joshua A. , Brown Matthew F. , Zewe James , Taguchi Takahiro , Kuan Shin-Fan , Schöffski Patrick , Debiec-Rychter Maria , Duensing Anette
Published: March 2023

PDF - 1670K, Inhibitors of transcription and of topoisomerase II are effective in imatinib-/sunitinib-double-resistant primary GIST cells and GIST xenograft models.
Supplementary Figure 2 from Unbiased Compound Screening Identifies Unexpected Drug Sensitivities and Novel Treatment Options for Gastrointestinal Stromal Tumors
Authors: Boichuk Sergei , Lee Derek J. , Mehalek Keith R. , Makielski Kathleen R. , Wozniak Agnieszka , Seneviratne Danushka S. , Korzeniewski Nina , Cuevas Rolando , Parry Joshua A. , Brown Matthew F. , Zewe James , Taguchi Takahiro , Kuan Shin-Fan , Schöffski Patrick , Debiec-Rychter Maria , Duensing Anette
Published: March 2023

PDF - 892K, The topoisomerase II inhibitor mitoxantrone (MXN) induces GIST cell apoptosis and cell cycle arrest.
Supplementary Tables 1 - 3, Figures 1 - 2 from RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation
Authors: Mirschberger Christian , Schiller Christian B. , Schräml Michael , Dimoudis Nikolaos , Friess Thomas , Gerdes Christian A. , Reiff Ulrike , Lifke Valeria , Hoelzlwimmer Gabriele , Kolm Irene , Hopfner Karl-Peter , Niederfellner Gerhard , Bossenmaier Birgit
Published: March 2023

PDF file - 470K, Calculation of tumor growth inhibition. Tumor growth inhibition was calculated compared with respective controls using a standard formula. Surface plasmon resonance. Calculation of kinetic parameters ka (1/Ms), kd (1/s) and KD (M) of the antibody/receptor domain. Supplementary Table 1. Surface plasmon resonance - Kinetic data (ka, kd, and KD) for the binding of RG7116 and cetuximab to their respective antigen across the entire temperature gradient investigated. Supplementary Table 2. Surface plasmon resonance - Detailed analysis of the Van't Hoff and Eyring association/dissociation thermodynamic parameters for the binding of RG7116/HER3 and cetuximab/HER1. Supplementary Figure S1. Van't Hoff and Eyring association/dissociation plots showing the linear transformation of affinity (KD) and kinetic (ka and kd) parameters varying with reaction temperature for RG7116/HER3 and cetuximab/HER1. Structure of the HER3-ECD::Fab(RG7116) complex - Preparation and crystallization. Detailed methodology for the preparation and crystallization of the Fab fraction of RG7116 bound to HER3-ECD Structure of the HER3-ECD::Fab(RG7116) complex - Data collection, model building and refinement. Detailed methodology for the processing of X-ray diffraction data and solving of the Supplementary Table 3. Data collection and refinement statistics for the HER3-ECD::Fab(RG7116) complex. Supplementary Figure S2. Comparison of apo- and Fab(RG7116) bound HER3-ECD, 2Fo-Fc electron density composite omit map and electrostatic surface calculation of anti-HER3 binding epitope. Sensitivity of models investigated in vivo to therapeutic agents. Details of the common chemotherapeutic agents that the cell lines/tissue fragments used in this study were resistant to.
Supplementary Table 1 from p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis
Authors: Zhong Jian , Ding Liya , Bohrer Laura R. , Pan Yunqian , Liu Ping , Zhang Jun , Sebo Thomas J. , Karnes R. Jeffrey , Tindall Donald J. , van Deursen Jan , Huang Haojie
Published: March 2023

PDF file - 62KB, Primers for genotyping and RT-qPCR.
Supplementary Figure Legend from Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging
Authors: Allen Michael D. , Luong Phuong , Hudson Chantelle , Leyton Julius , Delage Barbara , Ghazaly Essam , Cutts Rosalind , Yuan Ming , Syed Nelofer , Lo Nigro Cristiana , Lattanzio Laura , Chmielewska-Kassassir Malgorzata , Tomlinson Ian , Roylance Rebecca , Whitaker Hayley C. , Warren Anne Y. , Neal David , Frezza Christian , Beltran Luis , Jones Louise J. , Chelala Claude , Wu Bor-Wen , Bomalaski John S. , Jackson Robert C. , Lu Yong-Jie , Crook Tim , Lemoine Nicholas R. , Mather Stephen , Foster Julie , Sosabowski Jane , Avril Norbert , Li Chien-Feng , Szlosarek Peter W.
Published: March 2023

PDF file - 65K
Supplementary Methods from p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis
Authors: Zhong Jian , Ding Liya , Bohrer Laura R. , Pan Yunqian , Liu Ping , Zhang Jun , Sebo Thomas J. , Karnes R. Jeffrey , Tindall Donald J. , van Deursen Jan , Huang Haojie
Published: March 2023

PDF file - 88KB
Supplementary Figure Legends from p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis
Authors: Zhong Jian , Ding Liya , Bohrer Laura R. , Pan Yunqian , Liu Ping , Zhang Jun , Sebo Thomas J. , Karnes R. Jeffrey , Tindall Donald J. , van Deursen Jan , Huang Haojie
Published: March 2023

PDF file - 103KB
Supplementary Figure 5 from p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis
Authors: Zhong Jian , Ding Liya , Bohrer Laura R. , Pan Yunqian , Liu Ping , Zhang Jun , Sebo Thomas J. , Karnes R. Jeffrey , Tindall Donald J. , van Deursen Jan , Huang Haojie
Published: March 2023

PDF file - 143KB, Effect of p300 depletion on expression of non-AR target genes in human and mouse PCa cells.
Supplementary Information from Cancer-Associated Mutations in Healthy Individuals: Assessing the Risk of Carcinogenesis
Authors: Rodriguez-Brenes Ignacio A. , Komarova Natalia L. , Wodarz Dominik
Published: March 2023

PDF file - 58KB, Algorithm and supplementary figure for the agent-based model. S1 - Simulations using the agent-based model (no replication limits).
Supplementary Tables 1 - 4 and Figures 1 - 2 from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma
Authors: Stopczynski Rachelle E. , Normolle Daniel P. , Hartman Douglas J. , Ying Haoqiang , DeBerry Jennifer J. , Bielefeldt Klaus , Rhim Andrew D. , DePinho Ronald A. , Albers Kathryn M. , Davis Brian M.
Published: March 2023

PDF file - 457KB, Supplementary Table 1. qRT-PCR murine primer sequences used in this study. Supplementary Table 2. qRT-PCR human primer sequences used in this study. Supplementary Table 3. Comparison of changes in house keeping genes during cancer progression. Supplementary Table 4. RT-PCR analysis of gene expression in PDAC cell lines. Supplementary Figure 1. Histological analysis of cancer progression. Supplementary Figure 2. tdTomato-positive cells are not found in control celiac ganglion (CG).
Supplementary Figure 7 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: March 2023

PDF file - 45KB, Supplementary Figure S7 shows the molecular structure and pharmacokinetic of TBK1-II In NOD/SCID mice.
Supplementary Figure 5 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: March 2023

PDF file - 753KB, Supplementary Figure S5 shows representative images of HCC1954 and SKBR3 HER2+ BC cells transduced with indicated lenti-shRNA against human Tbk1 or lenti-GFP.
Supplementary Figure S6 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: March 2023

Ectopic expression or knockdown of LIMD2 stimulates or abrogates cell migration and anchorage-independent growth.
Data Supplement from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L.
Published: March 2023

Supplementary Figure 2. More aggressive breast cancers express lower levels of BMP4.
Data Supplement from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L.
Published: March 2023

Supplementary Figure 5. BMP4 responsiveness of myeloid cells and MDSC.
Supplementary Figures 1 - 7, Table 1 from A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells
Authors: Stehn Justine R. , Haass Nikolas K. , Bonello Teresa , Desouza Melissa , Kottyan Gregg , Treutlein Herbert , Zeng Jun , Nascimento Paula R.B.B. , Sequeira Vanessa B. , Butler Tanya L. , Allanson Munif , Fath Thomas , Hill Timothy A. , McCluskey Adam , Schevzov Galina , Palmer Stephen J. , Hardeman Edna C. , Winlaw David , Reeve Vivienne E. , Dixon Ian , Weninger Wolfgang , Cripe Timothy P. , Gunning Peter W.
Published: March 2023

PDF file - 1137K, Supplementary Figure 1: Tropomyosin siRNA knockdown is isoform specific and does not result in any compensation. Supplementary Figure 2: TR100 nullifies the impact of Tm5NM1 on actin filament depolymerization kinetics. Supplementary Figure 3: Anti-Tropomyosin compound impact on the actin cytoskeleton assessed by the microfilament disruption assay. Supplementary Figure 4: TR100 targets the actin cytoskeleton and preferentially disrupts LMW-cytoskeletal tropomyosin containing filaments. Supplementary Figure 5: TR100 shows no overt impact on synaptic integrity of hippocampal neurons. Supplementary Figure 6: TR100 induces apoptosis in tumor cells via a mitochondrial pathway. Supplementary Figure 7: TR100 does not impact liver function in vivo.Supplementary Table 1: Summary of impact of TR100 on tumor cell viability.
Supplementary Methods from Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
Authors: Weber Thomas G. , Osl Franz , Renner Anja , Pöschinger Thomas , Galbán Stefanie , Rehemtulla Alnawaz , Scheuer Werner
Published: March 2023

PDF file - 63KB, Fluorescence imaging - Fluorescence imaging was used for monitoring anti-DR5-Cy5 distribution in the mouse. Cell culture and cell inoculation of U87-Luc and U251 cell lines - U87-Luc and U251 were used for additional BBB penetration studies and were inoculated as described for D54-Caspase-3/7 GloSensor cell line.
Supplementary Methods and Figure Legend from Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling
Authors: Schroeder Anne , Herrmann Andreas , Cherryholmes Gregory , Kowolik Claudia , Buettner Ralf , Pal Sumanta , Yu Hua , Müller-Newen Gerhard , Jove Richard
Published: March 2023

PDF file - 112K
Supplementary Figure 3 from Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
Authors: Weber Thomas G. , Osl Franz , Renner Anja , Pöschinger Thomas , Galbán Stefanie , Rehemtulla Alnawaz , Scheuer Werner
Published: March 2023

PDF file - 936KB, Supplementary Figure 3 - Apoptosis and fluorescence imaging reveal that 3.9-7.0% of anti-DR5-Cy5 given i.v. reaches subcutaneous D54-Caspase-3/7 GloSensor tumors.
Supplementary Figure 1, Tables 1 - 3 from A Common Cancer-Associated DNA Polymerase ϵ Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading
Authors: Kane Daniel P. , Shcherbakova Polina V.
Published: March 2023

PDF file - 63KB, Supplementary Figure S1. Strategy for PCR amplification of the exonuclease domain region of POLE. Supplementary Table S1. Primers and reaction conditions used to amplify the entire coding sequence of POLE from tumor sample T-04-364 by nested PCR. Supplementary Table S2. Yeast strains used in the study. Supplementary Table S3. Properties of previously characterized yeast pol2 mutators.
Supplementary Tables 1 - 6 from p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages
Authors: Lowe Julie M. , Menendez Daniel , Bushel Pierre R. , Shatz Maria , Kirk Erin L. , Troester Melissa A. , Garantziotis Stavros , Fessler Michael B. , Resnick Michael A.
Published: March 2023

PDF file - 63K, Table S1. Responsiveness of pro-inflammatory gene expression to p53 activation. Table S2. GO analysis of commonly regulated genes. Table S3. Conserved transcription factor binding sites in the promoters of commonly regulated genes. Table S4. Number of the commonly regulated genes with associated p53REs, kB sites, or both. Table S5. Highly induced common genes. Table S6. p53 response elements identified with p53 Scan.
Supplementary Figures 1 - 4 from p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages
Authors: Lowe Julie M. , Menendez Daniel , Bushel Pierre R. , Shatz Maria , Kirk Erin L. , Troester Melissa A. , Garantziotis Stavros , Fessler Michael B. , Resnick Michael A.
Published: March 2023

PDF file - 249K, Figure S1. p53 activation by Nutlin-3 induces pro-inflammatory genes. Figure S2. NF-kB plays a role in gene regulation induced by Nutlin-3. Figure S3. Microarray analysis Nutlin-3 and LPS-treated macrophages identifies chemokine genes. Figure S4. p53 is activated in TCMs.
Supplementary Tables 1 - 3 from Phosphorylation at Ser-181 of Oncogenic KRAS Is Required for Tumor Growth
Authors: Barceló Carles , Paco Noelia , Morell Mireia , Alvarez-Moya Blanca , Bota-Rabassedas Neus , Jaumot Montserrat , Vilardell Felip , Capella Gabriel , Agell Neus
Published: March 2023

PDF file - 20K, Table S1. Statistics for the values of volumes (mm3) represented in Fig1 pannel B. Table S2. Statistics for the values of weights (g) represented in Fig1 panel C. Table S3. KRAS mutations I tumor cell lines used to determine PKC inhibition sensitivity and KRAS phosphorylation.
Supplementary Figure 5 from Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase
Authors: Xie Maohua , Yen Yun , Owonikoko Taofeek K. , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Doetsch Paul W. , Deng Xingming
Published: March 2023

PDF file - 66K, The BH4 domain is essential for Bcl2 to cause the asymmetrical DNA replication.
Supplementary Figures 1 - 12 from CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy
Authors: Ding Liya , Chen Shuai , Liu Ping , Pan Yunqian , Zhong Jian , Regan Kevin M. , Wang Liguo , Yu Chunrong , Rizzardi Anthony , Cheng Liang , Zhang Jun , Schmechel Stephen C. , Cheville John C. , Van Deursen Jan , Tindall Donald J. , Huang Haojie
Published: March 2023

PDF file - 2002KB, Figure S1. Expression of CBP protein in benign and malignant human prostate tissues. Figure S2. Evaluation of expression of CBP protein in human PIN lesions. Figure S3 Generation of prostate-specific Cbp and Cbp/Pten deletion mice. Figure S4. Immunofluorescent cytochemistry and histological analysis of prostates in Cbp knockout and control mice. Figure S5. Effect of CBP and PTEN knockdown on expression of cell cycle-regulatory genes and the levels of H3K27Ac and H3K27me3 in LAPC-4 PCa cells. Figure S6. IHC analysis of DAB2IP, p27KIP1 and EZH2 protein in DU145 cells. Figure S7. Quantitative data of immunohistochemical results in prostate sections of Cbp/Pten deficient and 'wild-type' mice. Figure S8. Binding of EZH2 at DAB2IP, p27KIP1 and p21CIP1 loci in DU145 cells. Figure S9. Effect of CBP and PTEN deficiency on H3K27Ac and H3K27me3 levels at DAB2IP, p27KIP1 and p21CIP1 gene loci. Figure S10. Quantitative data of immunohistochemical results of proteins examined in Figure 6 in prostate sections of 6-month-old CbpL/L;PtenL/+ and Cbppc-/-;Ptenpc+/- mice Figure S11. The effect of panobinostat (LBH589) on H3K27Ac and H3K27me3 levels at the p21CIP1 locus and expression of phosphorylated AKT (AKT-p) and PHLPP1 in DU145 cells and quantification of IHC for Akt-p, H3K27Ac, H3K27me3, Ki-67 and TUNEL in mouse prostate tissues. Figure S12. Effects of LBH589 on apoptotic signaling pathways in prostate cancer cells in vitro and in vivo.
Supplementary Figure 3 from Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase
Authors: Xie Maohua , Yen Yun , Owonikoko Taofeek K. , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Doetsch Paul W. , Deng Xingming
Published: March 2023

PDF file - 54K, Bcl2 interacts with p53R2.
Supplementary Figure 1 from Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase
Authors: Xie Maohua , Yen Yun , Owonikoko Taofeek K. , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Doetsch Paul W. , Deng Xingming
Published: March 2023

PDF file - 111K, Bcl2 downregulates intracellular dNTPs via inhibition of RNR activity.
Supplementary Figure S7 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: March 2023

Supplementary Figure S7. ETBR expression is not associated with chemoresistance and survival in EOC patients.
Supplementary Figure S5 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: March 2023

Supplementary Figure S5. Apoptotic effects of macitentan on EOC cells and tumor-associated endothelial cells.
Data Supplement from Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC
Authors: Tchaicha Jeremy H. , Akbay Esra A. , Altabef Abigail , Mikse Oliver R. , Kikuchi Eiki , Rhee Kevin , Liao Rachel G. , Bronson Roderick T. , Sholl Lynette M. , Meyerson Matthew , Hammerman Peter S. , Wong Kwok-Kin
Published: March 2023

Supplemental Table 2. p53 status and relation to tumor penetrance.
Supplementary Figure S4 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: March 2023

Supplementary Figure S4. Macitentan and silencing of ÃŽÂ²-arr1 promotes antiproliferative effects and sensitizes chemoresistant cells to drug-induced apoptosis.
Supplementary Figure 3 from Critical Tumor Suppressor Function Mediated by Epithelial Mig-6 in Endometrial Cancer
Authors: Kim Tae Hoon , Lee Dong-Kee , Cho Sung-Nam , Orvis Grant D. , Behringer Richard R. , Lydon John P. , Ku Bon Jeong , McCampbell Adrienne S. , Broaddus Russell R. , Jeong Jae-Wook
Published: March 2023

PDF file - 249K, Expression of PR protein and its target genes in Wnt7acre+ Mig-6f/f mice after P4 treatment.
Supplementary Figures 1 - 5 from FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway
Authors: Lin Aifu , Piao Hai-long , Zhuang Li , Sarbassov Dos D. , Ma Li , Gan Boyi
Published: March 2023

PDF file - 232KB, Figure S1: FoxO subcellular localization under NVP-BEZ235, BKM120, or MK-2206 treatment. Figure S2: Quantified ratios of AKT phosphorylation levels to total AKT levels in FoxO WT and KO cells after 50 nM NVP-BEZ235 treatment. Figure S3: The effect of high dosage NVP-BEZ235 on cell proliferation in FoxO WT and KO cells. Figure S4: Rictor knockdown potentiates cell proliferation suppression and cell death induction in response to NVP-BEZ235 treatment in RCC cells. Figure S5: The expression levels of p27 and Bim in FoxO deficient cells under NVPBEZ235 treatment.
Supplementary Figure 5 from Maintaining Glycogen Synthase Kinase-3 Activity Is Critical for mTOR Kinase Inhibitors to Inhibit Cancer Cell Growth
Authors: Koo Junghui , Yue Ping , Gal Anthony A. , Khuri Fadlo R. , Sun Shi-Yong
Published: March 2023

PDF file - 98KB, Inhibition of neddylation with MLN4924 prevents cyclin D1 reduction induced by INK128.
Supplementary Figure Legend from Cysteine Catabolism: A Novel Metabolic Pathway Contributing to Glioblastoma Growth
Authors: Prabhu Antony , Sarcar Bhaswati , Kahali Soumen , Yuan Zhigang , Johnson Joseph J. , Adam Klaus-Peter , Kensicki Elizabeth , Chinnaiyan Prakash
Published: March 2023

PDF file - 53K
Supplementary Figure 1 from Maintaining Glycogen Synthase Kinase-3 Activity Is Critical for mTOR Kinase Inhibitors to Inhibit Cancer Cell Growth
Authors: Koo Junghui , Yue Ping , Gal Anthony A. , Khuri Fadlo R. , Sun Shi-Yong
Published: March 2023

PDF file - 77KB, Combination indexes (CIs) of INK128 and SB216763 (SB) in different NSCLC cell lines.