bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of the Composition of the Activator on Mechanical Characteristics of a Geopolymer
Authors: Lopes Adelino V. , Lopes Sergio M.R. , Pinto Isabel
Published: May 2020

Geopolymer materials are characterized by their high durability and low carbon dioxide emissions, when compared with more traditional materials, like concrete made from ordinary Portland cement. These are interesting advantages and might lead to a more sustainable construction industry. The aim of this study is the characterization of the mechanical behavior of the materials obtained by the activation of metakaolin. The activator is a mixture of sodium hydroxide with sodium silicate in different proportions. The influence of the composition of activator is studied. For the analysis of the mechanical properties of the different mixtures two different types of tests were performed, bending tensile strength tests and compressive strength tests. The results show that an activator with not less than 300 g of sodium hydroxide and not exceeding 600 g of sodium silicate per 750 g of metakaolin gives the best results, for both tensile strength and compressive strength.
Triterpenic Acids as Non-Competitive α-Glucosidase Inhibitors from Boswellia elongata with Structure-Activity Relationship: In Vitro and In Silico Studies
Authors: Ur Rehman Najeeb , Halim Sobia Ahsan , Al-Azri Mohammed , Khan Majid , Khan Ajmal , Rafiq Kashif , Al-Rawahi Ahmed , Csuk Rene , Al-Harrasi Ahmed
Published: May 2020

Fourteen triterpene acids, viz., three tirucallane-type (1–3), eight ursane-type (4–11), two oleanane-type (12, 13) and one lupane type (21), along with boswellic aldehyde (14), α-amyrine (15), epi-amyrine (16), straight chain acid (17), sesquiterpene (19) and two cembrane-type diterpenes (18, 20) were isolated, first time, from the methanol extract of Boswellia elongata resin. Compound (1) was isolated for first time as a natural product, while the remaining compounds (2‒21) were reported for first time from B. elongata. The structures of all compounds were confirmed by advanced spectroscopic techniques including mass spectrometry and also by comparison with the reported literature. Eight compounds (1–5, 11, 19 and 20) were further screened for in vitro α-glucosidase inhibitory activity. Compounds 3–5 and 11 showed significant activity against α-glucosidase with IC50 values ranging from 9.9–56.8 μM. Compound 4 (IC50 = 9.9 ± 0.48 μM) demonstrated higher inhibition followed by 11 (IC50 = 14.9 ± 1.31 μM), 5 (IC50 = 20.9 ± 0.05 μM) and 3 (IC50 = 56.8 ± 1.30 μM), indicating that carboxylic acid play a key role in α-glucosidase inhibition. Kinetics studies on the active compounds 3–5 and 11 were carried out to investigate their mechanism (mode of inhibition and dissociation constants Ki). All compounds were found to be non-competitive inhibitors with Ki values in the range of 7.05 ± 0.17–51.15 ± 0.25 µM. Moreover, in silico docking was performed to search the allosteric hotspot for ligand binding which is targeted by our active compounds investigates the binding mode of active compounds and it was identified that compounds preferentially bind in the allosteric binding sites of α-glucosidase. The results obtained from docking study suggested that the carboxylic group is responsible for their biologic activities. Furthermore, the α-glucosidase inhibitory potential of the active compounds is reported here for the first time.
Protective Role of Spirulina platensis against Bifenthrin-Induced Reprotoxicity in Adult Male Mice by Reversing Expression of Altered Histological, Biochemical, and Molecular Markers Including MicroRNAs
Authors: Barkallah Mohamed , Ben Slima Ahlem , Elleuch Fatma , Fendri Imen , Pichon Chantal , Abdelkafi Slim , Baril Patrick
Published: May 2020

The potential reprotoxicity of bifenthrin remains unclear if only the common clinical indicators of reproductive disease are examined. The present study aimed to investigate the efficacy of Spirulina platensis, a microalga rich in antioxidant compounds, against bifenthrin-induced testicular oxidative damage in male mice. At the first, we demonstrate that administration of bifenthrin resulted in a decline of testosterone level and in deterioration of sperm quality that was correlated with significant transcription changes of some specific mRNA and microRNA involved in cholesterol transport, testosterone synthesis, and spermatogenesis. At the biochemical level, we found that oxidative stress was obvious in the bifenthrin group, as evidenced by increase in malondialdehyde (MDA), protein carbonyls (PCO), reactive oxygen species (ROS), and nitrite oxide (NO) that was correlated with activation of genes related to mitochondrial apoptotic signal pathways. We then brought, for the first time to our knowledge, solid and complete experimental evidences that administration of mice with Spirulina extract was sufficient to protect against deleterious effects BF in testicular tissues by abrogating the change in antioxidant enzyme activities; the increase in MDA, PCO, and NO concentrations; and the altered expression level of miRNA and mRNA involved in spermatogenesis. We finally demonstrate that Spirulina restores the production of testosterone in mice as well as epididymal sperm viability and motility. These results suggest a potential antitoxic activity of Tunisian Spirulina deserving further attention.
Biomimicry for Regenerative Built Environments: Mapping Design Strategies for Producing Ecosystem Services
Authors: Pedersen Zari Maibritt , Hecht Katharina
Published: May 2020

Built environment professionals must solve urgent and complex problems related to mitigating and adapting to climate change and biodiversity loss. Cities require redesign and retrofit so they can become complex systems that create rather than diminish ecological and societal health. One way to do this is to strategically design buildings and cities to generate and provide ecosystem services. This is an aspect of biomimicry, where whole ecosystems and their functions are emulated, in order to positively shift the ecological performance of buildings and urban settings. A small number of methodologies and frameworks for ecosystem services design have been proposed, but their use is not wide spread. A key barrier is the lack of translational work between ecology concepts and practical examples of ecosystem services design for a built environment context. In response, this paper presents research underpinning the creation of a qualitative relational diagram in an online interactive format that relates ecosystem services concepts to design strategies, concepts, technologies, and case studies in a format for use by built environment professionals. The paper concludes that buildings and whole cities should be expected to become active contributors to socio-ecological systems because, as the diagram shows, many strategies and technologies to enable this already exist.
Survey for Assessment of a Person’s Legal Consciousness: Development and Preliminary Validation
Authors: Molotova Victoria , Molotov Alexander , Kashirsky Dmitry , Sabelnikova Natalia
Published: May 2020

The results of the development and preliminary assessment of the psychometric properties of the questionnaire of legal consciousness of a person are presented. Theoretical justification is given for the structure of the questionnaire containing six subscales. One scale relates to the individual’s awareness of constitutional rights and freedoms, enshrined in the Universal Declaration of Human Rights and the Constitution of the Russian Federation (personal, economic, political, cultural and social rights). The other five scales relate to the importance of constitutional rights and freedoms for the subject. The content validity of the tool was confirmed by expert assessments of professional lawyers—specialists in constitutional law—and the results obtained with semi-structured interviews (n = 30). The construct validity of the tool was established using exploratory factor analysis and tested by confirmatory factor analysis for student sample (n = 100). Cronbach’s alpha indicated high degree of internal consistency of the subscales. Currently, we continue improving the psychometric characteristics of the measure. The questionnaire obtained as a result of this work can be used to assess the level of a person’s legal consciousness development, and in particular, during the professional personnel selection for the state and civil service. The results of large-scale studies carried out with the help of this tool can be implemented in the activities of public authorities in order to improve the legislative process, taken into account by public organizations and authorities involved in the spread of legal education and legal culture in the framework of state policy on the development of legal consciousness and legal culture.
The Study of Reverse Water Gas Shift Reaction Activity over Different Interfaces: The Design of Cu-Plate ZnO Model Catalysts
Authors: Wen Jinjun , Huang Chunlei , Sun Yuhai , Liang Long , Zhang Yudong , Zhang Yujun , Fu Mingli , Wu Junliang , Chen Limin , Ye Daiqi
Published: May 2020

CO2 hydrogenation to methanol is one of the main and valuable catalytic reactions applied on Cu/ZnO-based catalysts; the interface formed through Zn migration from ZnO support to the surface of Cu nanoparticle (ZnOx-Cu NP-ZnO) has been reported to account for methanol synthesis from CO2 hydrogenation. However, the accompanied reverse water gas shift (RWGS) reaction significantly decreases methanol selectivity and deactivates catalysts soon. Inhibition of RWGS is thus of great importance to afford high yield of methanol. The clear understanding of the reactivity of RWGS reaction on both the direct contact Cu-ZnO interface and ZnOx-Cu NP-ZnO interface is essential to reveal the low methanol selectivity in CO2 hydrogenation to methanol and look for efficient catalysts for RWGS reaction. Cu doped plate ZnO (ZnO:XCu) model catalysts were prepared through a hydrothermal method to simulate direct contact Cu-ZnO interface and plate ZnO supported 1 wt % Cu (1Cu/ZnO) catalyst was prepared by wet impregnation for comparison in RWGS reaction. Electron paramagnetic resonance (EPR), XRD, SEM, Raman, hydrogen temperature-programmed reduction (H2-TPR) and CO2 temperature-programmed desorption (CO2-TPD) were employed to characterize these catalysts. The characterization results confirmed that Cu incorporated into ZnO lattice and finally formed direct contact Cu-ZnO interface after H2 reduction. The catalytic performance revealed that direct contact Cu-ZnO interface displays inferior RWGS reaction reactivity at reaction temperature lower than 500 °C, compared with the ZnOx-Cu NP-ZnO interface; however, it is more stable at reaction temperature higher than 500 °C, enables ZnO:XCu model catalysts superior catalytic activity to that of 1Cu/ZnO. This finding will facilitate the designing of robust and efficient catalysts for both CO2 hydrogenation to methanol and RWGS reactions.
An Innovative Lipidomic Workflow to Investigate the Lipid Profile in a Cystic Fibrosis Cell Line
Authors: Dei Cas Michele , Zulueta Aida , Mingione Alessandra , Caretti Anna , Ghidoni Riccardo , Signorelli Paola , Paroni Rita
Published: May 2020

Altered lipid metabolism has been associated to cystic fibrosis disease, which is characterized by chronic lung inflammation and various organs dysfunction. Here, we present the validation of an untargeted lipidomics approach based on high-resolution mass spectrometry aimed at identifying those lipid species that unequivocally sign CF pathophysiology. Of n.13375 mass spectra recorded on cystic fibrosis bronchial epithelial airways epithelial cells IB3, n.7787 presented the MS/MS data, and, after software and manual validation, the final number of annotated lipids was restricted to n.1159. On these lipids, univariate and multivariate statistical approaches were employed in order to select relevant lipids for cellular phenotype discrimination between cystic fibrosis and HBE healthy cells. In cystic fibrosis IB3 cells, a pervasive alteration in the lipid metabolism revealed changes in the classes of ether-linked phospholipids, cholesterol esters, and glycosylated sphingolipids. Through functions association, it was evidenced that lipids variation involves the moiety implicated in membrane composition, endoplasmic reticulum, mitochondria compartments, and chemical and biophysical lipids properties. This study provides a new perspective in understanding the pathogenesis of cystic fibrosis and strengthens the need to use a validated mass spectrometry-based lipidomics approach for the discovery of potential biomarkers and perturbed metabolism.
A Novel Function for KLF4 in Modulating the De-Differentiation of EpCAM−/CD133− nonStem Cells into EpCAM+/CD133+ Liver Cancer Stem Cells in HCC Cell Line HuH7
Authors: Firtina Karagonlar Zeynep , Akbari Soheil , Karabicici Mustafa , Sahin Eren , Tercan Avci Sanem , Ersoy Nevin , Eren Ates Kıvılcım , Balli Tugsan , Karacicek Bilge , Kaplan Kubra Nur , Celiker Canan , Atabey Nese , Erdal Esra
Published: May 2020

The complex and heterogeneous nature of hepatocellular carcinoma (HCC) hampers the identification of effective therapeutic strategies. Cancer stem cells (CSCs) represent a fraction of cells within tumors with the ability to self-renew and differentiate, and thus significantly contribute to the formation and maintenance of heterogeneous tumor mass. Increasing evidence indicates high plasticity in tumor cells, suggesting that non-CSCs could acquire stem cell properties through de-differentiation or reprogramming processes. In this paper, we reveal KLF4 as a transcription factor that can induce a CSC-like phenotype in non-CSCs through upregulating the EpCAM and E-CAD expression. Our studies indicated that KLF4 could directly bind to the promoter of EpCAM and increase the number of EpCAM+/CD133+ liver cancer stem cells (LCSCs) in the HuH7 HCC cell line. When KLF4 was overexpressed in EpCAM−/CD133− non-stem cells, the expressions of hepatic stem/progenitor cell genes such as CK19, EpCAM and LGR5 were significantly increased. KLF4 overexpressing non-stem cells exhibited greater cell viability upon sorafenib treatment, while the cell migration and invasion capabilities of these cells were suppressed. Importantly, we detected an increased membranous expression and colocalization of β-CAT, E-CAD and EpCAM in the KLF4-overexpressing EpCAM−/CD133− non-stem cells, suggesting that this complex might be required for the cancer stem cell phenotype. Moreover, our in vivo xenograft studies demonstrated that with a KLF4 overexpression, EpCAM−/CD133− non-stem cells attained an in vivo tumor forming ability comparable to EpCAM+/CD133+ LCSCs, and the tumor specimens from KLF4-overexpressing xenografts had increased levels of both the KLF4 and EpCAM proteins. Additionally, we identified a correlation between the KLF4 and EpCAM protein expressions in human HCC tissues independent of the tumor stage and differentiation status. Collectively, our data suggest a novel function for KLF4 in modulating the de-differentiation of tumor cells and the induction of EpCAM+/CD133+ LCSCs in HuH7 HCC cells.
Microstructure and Mechanical Properties of an Austenitic CrMnNiMoN Spring Steel Strip with a Reduced Ni Content
Authors: Schröder Christina , Wendler Marco , Volkova Olena , Weiß Andreas
Published: May 2020

The article presents the mechanical properties of the austenitic stainless steel X5CrMnNiMoN16-4-4 after deformation by cold rolling and subsequent short-term tempering (deformation and partitioning (D&P) treatment). Tensile strengths of 1700–900 MPa and beyond were achieved both after work hardening and in the D&P-treated strip. The initial state of austenite in terms of grain size and pre-strengthening, as well as the selected cold rolling temperature significantly influenced the deformation-induced formation of α’ martensite and thus the flow and hardening behavior of the steel. The usage of two different rolling temperature regimes showed that the strength properties in the cold strip can be specifically adjusted. Lower deformation-induced martensite fractions enabled a larger thickness reduction of the strip without increasing the rolling force, while high deformation-induced martensite fractions led to strong hardening at low deformation levels. The D&P-treatment permits the strength of the cold-rolled strip with a predominantly austenitic microstructure to be increased to the required level. The total elongation of such a D&P strip was well over 2%. The D&P treatment of the spring steel strip is a cost-effective alternative to conventional tempering treatment.
Rigid Shape Registration Based on Extended Hamiltonian Learning
Authors: Yi Jin , Zhang Shiqiang , Cao Yueqi , Zhang Erchuan , Sun Huafei
Published: May 2020

Shape registration, finding the correct alignment of two sets of data, plays a significant role in computer vision such as objection recognition and image analysis. The iterative closest point (ICP) algorithm is one of well known and widely used algorithms in this area. The main purpose of this paper is to incorporate ICP with the fast convergent extended Hamiltonian learning (EHL), so called EHL-ICP algorithm, to perform planar and spatial rigid shape registration. By treating the registration error as the potential for the extended Hamiltonian system, the rigid shape registration is modelled as an optimization problem on the special Euclidean group S E ( n ) ( n = 2 , 3 ) . Our method is robust to initial values and parameters. Compared with some state-of-art methods, our approach shows better efficiency and accuracy by simulation experiments.
Platform-Independent Malware Analysis Applicable to Windows and Linux Environments
Authors: Hwang Chanwoong , Hwang Junho , Kwak Jin , Lee Taejin
Published: May 2020

Most cyberattacks use malicious codes, and according to AV-TEST, more than 1 billion malicious codes are expected to emerge in 2020. Although such malicious codes have been widely seen around the PC environment, they have been on the rise recently, focusing on IoT devices such as smartphones, refrigerators, irons, and various sensors. As is known, Linux/embedded environments support various architectures, so it is difficult to identify the architecture in which malware operates when analyzing malware. This paper proposes an AI-based malware analysis technology that is not affected by the operating system or architecture platform. The proposed technology works intuitively. It uses platform-independent binary data rather than features based on the structured format of the executable files. We analyzed the strings from binary data to classify malware. The experimental results achieved 94% accuracy on Windows and Linux datasets. Based on this, we expect the proposed technology to work effectively on other platforms and improve through continuous operation/verification.
Green Activity-Based Costing Production Decision Model for Recycled Paper
Authors: Hsieh Chu-Lun , Tsai Wen-Hsien , Chang Yao-Chung
Published: May 2020

Using mathematical programming with activity-based costing (ABC) and based on the theory of constraints (TOC), this study proposed a green production model for the traditional paper industry to achieve the purpose of energy saving and carbon emission reduction. The mathematical programming model presented in this paper considers (1) revenue of main products and byproducts, (2) unit-level, batch-level, and product-level activity costs in ABC, (3) labor cost with overtime available, (4) machine cost with capacity expansion, (5) saved electric power and steam costs by using the coal as the main fuel in conjunction with Refuse Derived Fuel (RDF). This model also considers the constraint of the quantity of carbon equivalent of various gases that are allowed to be emitted from the mill paper-making process to conform to the environmental protection policy. A numerical example is used to demonstrate how to apply the model presented in this paper. In addition, sensitivity analysis on the key parameters of the model are used to provide further insights for this research.
Understanding Location Decisions of Energy Multinational Enterprises within the European Smart Cities’ Context: An Integrated AHP and Extended Fuzzy Linguistic TOPSIS Method
Authors: Porro Olga , Pardo-Bosch Francesc , Agell Núria , Sánchez Mónica
Published: May 2020

Becoming a smart city is one of the top priorities in the urban agenda of many European cities. Among the various strategies in the transition path, local governments seek to bring innovation to their cities by encouraging multinational enterprises to deploy their green energy services and products in their municipalities. Knowing how to attract these enterprises implies that political leaders understand the multi-criteria decision problem that the energy sector enterprises face when deciding whether to expand to one city or another. To this end, the purpose of this study is to design a new manageable and controllable framework oriented to European cities’ public managers, based on the assessment of criteria and sub-criteria governing the strategic location decision made by these enterprises. A decision support framework is developed based on the AHP technique combined with an extended version of the hesitant fuzzy linguistic TOPSIS method. The main results indicate the higher relative importance of government policies, such as degree of transparency or bureaucracy level, as compared to market conditions or economic aspects of the city’s host country. These results can be great assets to current European leaders, they show the feasibility of the method and open up the possibility to replicate the proposed framework to other sectors or geographical areas.
A Methodology for Measuring the Heat Release Efficiency in Bubbling Fluidised Bed Combustors
Authors: Müller Dominik , Plankenbühler Thomas , Karl Jürgen
Published: May 2020

Differences in the densities of bed material and—especially biogenic—solid fuels prevent an ideal mixture within bubbling fluidised bed (BFB) combustors. So, the presence of fuel particles is usually observed mainly near the surface of the fluidised bed. During their thermal conversion, this leads to a release of unburnt pyrolysis products to the freeboard of the combustion chamber. Within the further oxidation, these species will not transfer their heat-of-reaction to the inert bed material in the way of a convective heat transfer, but rather increase the gas phase temperature providing probably some additional radiative heat transfer to the dense bed. In this case, the so-called heat release efficiency to the fluidised bed, being the ratio of transferred heat to the fuel input, will be reduced. This paper presents a methodology to quantify this heat release efficiency with lab-scale experiments and the observed effects of common operating parameters like bed temperature, fluidisation ratio and fuel-to-air ratio. Experimental results show that the air-to-fuel ratio dominates the heat release efficiency, while bed temperature and fluidisation ratio have minor influences.
Application of a GIS-Based Fuzzy Multi-Criteria Evaluation Approach for Wind Farm Site Selection in China
Authors: Li Mengran , Xu Ye , Guo Junhong , Li Ye , Li Wei
Published: May 2020

The development and utilization of wind energy has alleviated the problems of energy shortage and environmental pollution; however, it caused many negative impacts due to suboptimal site selections. This study proposes an innovative method integrating Geographic Information System (GIS), fuzzy Analytic Hierarchy Process (FAHP), and fuzzy VIšekriterijumsko KOmpromisno Rangiranje (VIKOR) for site selection of wind farms in the Wafangdian region, China. The uncertainties caused by subjective judgments of the stakeholders were tackled by the FAHP method firstly, where weight values of six criteria were identified. Next, the fuzzy VIKOR method and GIS tool were used to generate the Qi value of each location for ranking their appropriate degrees for wind energy development. The results demonstrated that the middle and upper parts of the studied area are suitable for the exploitation of wind energy, while the central and eastern areas are unfavorable. The influences exerted by various weight combinations and climate change on a site suitability assessment were examined. The resulting comparison with existing wind farms reflected the practicability and reliability of the proposed method; the estimation of climate change impacts on site selection provided the suggestion and support of a long-term plan for wind power development, and even the energy structure adjustment scheme adapted to climate change.
Sensory Changes and Listeria monocytogenes Behavior in Sliced Cured Pork Loins during Extended Storage
Authors: Silva Rita , Pereira Jorge , Rouxinol Margarida , Patarata Luis
Published: May 2020

Cured pork loins are sausages with a production tradition in several regions worldwide. They are made from one of the noblest cuts of pork, and for this reason cured loins are one of the most expensive pork meat products. Establishing the correct shelf life allows products to be accepted by the consumer, and to avoid the costs associated with shorter shelf lives. The aim of this study is: (1) to establish proper shelf life by evaluating the willingness of participants to consume and the sensory modifications that occur during prolonged storage via Check All That Apply (CATA) questions; and (2) to study the behavior of Listeria monocytogenes through a microbial challenge test. Sliced cured pork loins can be stored at 6 ± 1 °C for 105 days while maintaining a consumer acceptance of more than 75%. The freshness loss was associated mainly with a decrease in aromatic notes (particularly the smoke and cured aroma), and with the appearance of spoiled characteristics, specifically a sour/vinegar aroma and acidic taste that were detected by a reduced proportion of participants. The freshness evaluation was positively influenced by the typical characteristics of cured products, such as color and a garlic and wine aroma. Sour/vinegar aroma and acidic taste were the attributes most associated with higher freshness penalization. During the period of the test, Listeria monocytogenes inoculated onto the cured loin slices did not grow.
A Remote Sensing-Based Method to Assess Water Level Fluctuations in Wetlands in Southern Brazil
Authors: Simioni João P. D. , Guasselli Laurindo A. , de Oliveira Gabriel , Mataveli Guilherme A. V. , dos Santos Thiago V.
Published: May 2020

The characterization of water level fluctuations is crucial to explain the hydrological processes that contribute to the maintenance of the structure and function of wetlands. The aim of this study was to develop a method based on remote sensing to characterize and map the water level variation patterns, evapotranspiration, discharge, and rainfall over wetlands in the Gravataí River basin, Rio Grande do Sul (RS), Brazil. For this purpose, ground-based measurements of rainfall, water discharge, and evapotranspiration together with satellite data were used to identify the apparent water level based on the normalized difference water index (NDWI). Our results showed that the variation of the water level followed the rainfall, water discharge, and evapotranspiration seasonal patterns in the region. The NDWI showed similar values to the ground-based data collected 10 days prior to satellite image acquisition. The proposed technique allows for quantifying the pattern of flood pulses, which play an important role for establishing the connectivity between different compartments of wetlands in the study area. We conclude that our methodology based on the use of satellite data and ground measurements was a useful proposition to analyze the water level variation patterns in an area of great importance in terms of environmental degradation and use of agriculture. The information obtained may be used as inputs in hydrologic models, allowing researchers to evaluate the impact, at both local and regional scales, caused by advance of agriculture into natural environments such as wetlands.
Quantitative Analysis of Selected Microorganisms Present at Various Sites in a Prosthetics Clinic and Dental Laboratory during Complete Denture Fabrication
Authors: Moodley Krystle L. , Owen C. Peter , Patel Mrudula
Published: May 2020

Background: Contamination with oral commensals and pathogenic microorganisms, and cross contamination between clinic and laboratory can occur. The amount of contamination has not been determined. Methods: Samples from different clinical and laboratory stages before and after disinfection (17 sites, 10 samples per stage) were collected. Laboratory surfaces and equipment were swabbed for 10 days (11 sites). Swabs were cultured for total mixed flora, Streptococci, Lactobacilli, Staphylococcus aureus, aerobic Gram-negative bacteria (AGNB) and Candida. Knowledge of infection control among staff and students was assessed. Results: Clinic: In total, 30–40% of the samples overall were contaminated with mixed flora and Streptococci of >100 cfu/swab; >100 cfu of AGNB and Candida were present on 6% and 1% of samples; 2% contained <100 cfu of S. aureus. Laboratory: In total, 17–48% of the samples overall were contaminated with mixed flora and Streptococci of >100 cfu/swab; >100 cfu of AGNB were present on 11% of samples; none contained >100 cfu of Candida. Disinfection significantly reduced the level of all organisms. Knowledge of infection control was sufficient, but compliance was poor. Conclusion: Although the count of mixed flora was high, potential pathogens such as S. aureus and Candida were low. In immunocompromised patients, this can become a problem.
Comparison of Maternal Functioning between Iranian Mothers with and without Depressive Symptoms: A Case-Control Study
Authors: Karami Chamgurdani Fatemeh , Barkin Jennifer L. , Curry Carolann L. , Mirghafourvand Mojgan
Published: May 2020

Postpartum depression (PPD) has adverse effects on the mother’s ability to work, her relationships, performance in other roles, and caregiving ability. The aim of this study was to compare levels of maternal functioning between mothers with depression symptoms and those without. The participants of this case-control study included 80 postpartum women (n = 40 with depressive symptoms and n = 40 with no depressive symptoms) referred to health centers in Tabriz, Iran, in 2018–2019. The case and control groups were matched for the number of deliveries (first or second deliveries) and the type of delivery (vaginal or cesarean section). A sociodemographic questionnaire, Edinburgh Postpartum Depression Scale (EPDS), and Barkin Index of Maternal Functioning (BIMF) were used for data collection. The relationship between maternal functioning and depression was assessed by conducting independent t-tests and Pearson correlation tests in bivariate analysis and applying the general linear model (GLM) in a multivariate analysis. There was no statistically significant difference between the two groups in terms of sociodemographic information. The mean (SD) total scores of maternal functioning in the case (depressed) and control (non-depressed) groups were 63.4 (12.2) and 93.3 (13.0), respectively. According to the independent t-test, this value in the control group was significantly higher than that of the case group (mean difference: −30.0; 95% confidence interval: −35.6 to −24.3; p < 0.001). In terms of the domains of the BIMF, based on the independent t-test, the mean score of all domains in the control group was significantly higher than that of the case group, except for the mother-child interaction dimension (p = 0.219). Based on the Pearson correlation test, there was significant negative correlation between the PPD score and total score of BIMF (r = −0.79, p < 0.001) and its domains (r = −0.81 to −0.54, p < 0.001). In addition, based on the GLM with adjusting the sociodemographic and obstetrics characteristics, the score of maternal functioning was significantly lower in the case group compared to the control group [β = −30.1; 95% CI: −36.8 to −23.4; p = 0.001]. The results of this study indicate that women with depressive symptoms have lower maternal functioning. Depressed women may find it difficult to perform their maternal duties and take care of themselves and other family members due to the burden of the depressive symptoms. Therefore, early diagnosis and treatment of postpartum depression can play an important role in improving daily maternal functioning.
Evidence-Based Integrated Intervention in Patients with Schizophrenia: A Pilot Study of Feasibility and Effectiveness in a Real-World Rehabilitation Setting
Authors: Nibbio Gabriele , Barlati Stefano , Cacciani Paolo , Corsini Paola , Mosca Alessandra , Ceraso Anna , Deste Giacomo , Vita Antonio
Published: May 2020

Impairment in real-world functioning remains one of the most problematic challenges that people with schizophrenia have to face. Various psychosocial interventions have proven to be effective in promoting recovery and improving functioning in schizophrenia; however, their implementation and their effectiveness in routine rehabilitation practice are still objects of study. The present pilot study aimed to assess the feasibility and effectiveness on clinical and real-world outcomes of an integrated treatment protocol composed of stable pharmacological treatment, computer-assisted cognitive remediation and social skills training provided in a rehabilitation center. Predictors of functional improvement were also assessed. Seventy-two patients diagnosed with schizophrenia participated in the study. A significant (p < 0.001) improvement in positive, negative and total symptoms, as well as in global clinical severity and real-world functioning outcomes was observed, with a large effect size in positive and total symptoms, global clinical severity and real-world functioning, and a moderate effect size on negative symptoms. Improvement in total symptoms (p < 0.001) and in global clinical severity (p = 0.007) emerged as individual predictors of functional improvement. These findings, although preliminary, suggest that an integrated, evidence-based treatment program is feasible and effective in a real-world rehabilitation context, and that similar interventions should be further implemented in everyday clinical practice.
Occupational, Transport, Leisure-Time, and Overall Sedentary Behaviors and Their Associations with the Risk of Cardiovascular Disease among High-Tech Company Employees
Authors: Liu Mei-Lan , Chang Chia-Hui , Hsueh Ming-Chun , Hu Yi-Jin , Liao Yung
Published: May 2020

This study examined the associations of overall and domain-specific (i.e., occupational, transport, and leisure-time) sedentary behaviors with cardiovascular disease (CVD) risk factors among high-tech company employees in Taiwan. A total of 363 participants employed at high-tech companies (mean age ± standard deviation: 37.4 ± 7.2 years) completed a questionnaire administered by email regarding their overall, occupational, transport, and leisure-time sedentary behaviors. Self-reported data of height and weight, blood pressure, blood sugar, and total cholesterol levels were also collected in 2018. An adjusted binary logistic regression model was employed in the analysis. After adjusting for sociodemographic variables, high-tech company employees who used a computer (or Internet) for more than 2 h per day during their leisure time were more likely to have CVD risk factors (odds ratio: 1.80; 95% confidence interval: 1.08–3.00). No significant associations with CVD risk factors were detected for total sedentary time, occupational sitting, television viewing time, and transport-related sitting. Despite the nature of cross-sectional design in this study, our findings may have considerable implications for intervention designers and policymakers of Taiwan. Developing effective strategies for limiting leisure-time computer use should be considered for the prevention of CVD among high-tech company employees.
Food Environment in the Lower Mississippi Delta: Food Deserts, Food Swamps and Hot Spots
Authors: Goodman Melissa , Thomson Jessica , Landry Alicia
Published: May 2020

The objectives for this study were to examine the location and density of measured food outlets in five rural towns in the Lower Mississippi Delta, determine the spatial location of Delta Healthy Sprouts (DHS) participants’ homes in the food environment, and examine relationships between the spatial location of participants’ homes and their diet quality. Using a food desert/food swamp framework, food outlet geographic locations were analyzed in relation to one another, the distance between DHS participants’ residence and closest food outlets by class were computed, and associations among residents’ diet quality, hot spot status, and census tract classification were explored. Of 266 food outlets identified, 11 (4%), 86 (32%), 50 (19%), and 119 (45%) were classified as grocery stores (GS), convenience stores (CS), full-service restaurants (FS), or fast food restaurants (FF), respectively. A third of participants lived in CS hot spots, while 22% lived in FF hot spots. DHS participants lived closer in miles to CS (0.4) and FF (0.5) as compared to GS (1.6) and FS (1.1) outlets. Participants bought most groceries at national chain grocery stores rather than their closest grocery store. The food environments of the five towns and associated neighborhoods in which DHS participants resided were not supportive of healthful eating, containing both food deserts and food swamps, often in overlapping patterns.
Commuters’ Personal Exposure Assessment and Evaluation of Inhaled Dose to Different Atmospheric Pollutants
Authors: Borghi Francesca , Spinazzè Andrea , Fanti Giacomo , Campagnolo Davide , Rovelli Sabrina , Keller Marta , Cattaneo Andrea , Cavallo Domenico Maria
Published: May 2020

Several studies evaluating exposure to pollutants in microenvironments (MEs) are available in the scientific literature, but studies that evaluate the inhaled doses of pollutants are few in number. Therefore, this study aimed to evaluate the exposure of commuters to different pollutants (i.e., nitrogen dioxide [NO2] and fractionated particulate matter [PM], including ultrafine particles [UFPs]) using miniaturized and portable real-time monitoring instruments in selected MEs; the inhaled doses of these pollutants were estimated for each of these MEs. Measurements were performed along a typical commute, considering different traffic and nontraffic MEs. Experimental data were collected over four working weeks in two different seasons (winter and summer). Different portable and miniaturized instruments were used to evaluate PM and NO2 exposure. Furthermore, physiological parameters were evaluated using a heart rate monitor. The principal results show that higher exposure levels were measured in Underground (for all PM fractions and NO2) and in Car (UFP), while lower levels were measured in Car (PM and NO2) and in Train (UFP). In contrast, higher values of the inhaled cumulative dose were estimated in environments defined as Other, followed by Walking (ht), while lower values were observed in Walking (lt) and in Car.
Examining Shopping Patterns, Use of Food-Related Resources, and Proposed Solutions to Improve Healthy Food Access Among Food Insecure and Food Secure Eastern North Carolina Residents
Authors: Lyonnais Mary Jane , Rafferty Ann P. , Jilcott Pitts Stephanie , Blanchard Rebecca J. , Kaur Archana P.
Published: May 2020

In the Southern United States (U.S.), food insecurity rates are higher in rural (20.8%) versus urban communities (15%). Food insecurity can exacerbate diet-related disease. Thus, the purpose of this study was to examine differences in the use of food-related community resources and potential solutions proposed among food insecure versus food secure residents. A community survey (n = 370) was conducted in rural eastern North Carolina, with questions pertaining to food security status and food-related resources. The IBM SPSS Statistics software and SAS software were used to examine differences in food-related resources, and qualitative data analysis was used to examine differences in solutions offered between food insecure and food secure participants. Of the 370 respondents, forty-eight-point-six percent were classified as food insecure. Food insecure participants were more likely to report shopping for groceries at a convenience/discount store, less likely to use their own vehicle for transportation, and less likely to purchase food from local producers. Food insecure participants were more likely to suggest solutions related to reducing the cost of healthy food, while food secure participants were more likely to suggest educational or convenience-related interventions.
Motoric Cognitive Risk Syndrome Using Three-Item Recall Test and Its Associations with Fall-Related Outcomes: The Korean Frailty and Aging Cohort Study
Authors: Shim Hayoung , Kim Miji , Won Chang Won
Published: May 2020

Motoric cognitive risk (MCR) syndrome is originally defined as the presence of subjective cognitive complaints (SCCs) and slow gait (SG). MCR is well known to be useful for predicting adverse health outcomes, including falls and dementia. However, around four out of five older Korean adults reported SCCs, thereby, it may not be discriminative to define MCR in Korea. We adopted the three-item recall (3IR) test, instead of SCCs, to define MCR. This cross-sectional analysis included 2133 community-dwelling older adults aged 70–84 years, without dementia or any dependence in activities of daily living from the Korean Frailty and Aging Cohort Study. The newly attempted criteria of MCR using 3IR were met by 105 participants (4.9%). MCR using 3IR showed synergistic effects on fall-related outcomes, whereas the conventional definition of MCR using SCCs was not superior to SG only. MCR using 3IR was associated with falls (odds ratio [OR]: 1.92; 95% confidence interval (CI): 1.16–3.16), recurrent falls (OR: 2.19; 95% CI: 1.12–4.32), falls with injury (OR: 1.98; 95% CI: 1.22–3.22), falls with fracture (OR: 2.51; 95% CI: 1.09–5.79), fear of falling (OR: 3.00; 95% CI: 1.83–4.92), and low activities-specific balance confidence (OR: 3.13; 95% CI: 1.57–6.25). We found that MCR using 3IR could be useful in predicting fall-related outcomes in a cultural background reporting more SCCs, such as Korea.
Assessment of Clayey Peloid Formulations Prior to Clinical Use in Equine Rehabilitation
Authors: Bastos Carla Marina , Rocha Fernando , Cerqueira Ângela , Terroso Denise , Sequeira Cristina , Tilley Paula
Published: May 2020

Clays are natural ingredients used to prepare therapeutic cataplasms suitable for topical application. The knowledge about these formulations and their preparations to be applied on humans and animals has been orally transmitted since ancient times. Several empirical methods using clays have demonstrated fast and effective results in the reduction of the inflammatory response and the formation of edemas in horse limbs. The use of traditional and alternative medicine, such as pelotherapy, is now becoming more popular in veterinarian medical practice, alone or combined with other therapies in horse muscle and tendon rehabilitation. This study characterizes the use of commercial equine clays and an old therapeutic clay cataplasm formulation, using acetic acid, to treat tendon injuries in horses. This work might contribute to a major database characterization of clays used empirically on equine health, the potential of dermal absorption, the risks of exposure to some toxic elements, and safety assessment for these formulations. The present study was carried out to characterize the suitability of four commercial equine clays (Group II) and a protocoled healing mixture: “clay acetic acid cataplasm”, (Group III), to treat tendon injuries in horses. In this mixture, three conventional “green” clays (Group I) without any mineralogical specificity were used and blended with acetic acid. The mineralogical composition was determined through X-ray powder diffraction and X-ray fluorescence data. To determine the performance of the samples, cooling kinetics, oil absorption, expandability, and specific surface area were measured. According to the mineralogical composition, Group I was mainly composed of carbonates and silicates, while Group II was much richer in silicates with the main clay minerals kaolinite and illite. Group II exhibited the highest values for As, Pb, Cr, Ni, and Zn, considered potentially toxic. Both groups showed low cation exchange capacities and exchanged mainly Ca2+, with the exception of VET.1 and VET.7, which also highlight Na+, and VET.5 and VET.6, which have K+ as an exchangeable main cation. The addition of acetic acid (Group III) does not reveal any significant chemical changes. The results confirm that both clay groups are adequate for the therapeutic propose. They have good plastic properties (skin adherence), good oil absorptive capabilities (cleaning), and exchange an essential physiological element, calcium. Group II has prior industrial preparation, which is probably why it showed better results. Group I presented lower heat retention capacity and higher abrasiveness, which could be improved using cosmetic additives. The clinical benefit of the “clay acetic acid cataplasm” (Group III) could be the systemic anti-inflammatory effect established by the acetic acid.
Children and Women’s Health in South East Asia: Gap Analysis and Solutions
Authors: Tangcharoensathien Viroj , Hirabayashi Kunihiko Chris , Topothai Chompoonut , Viriyathorn Shaheda , Chandrasiri Orana , Patcharanarumol Walaiporn
Published: May 2020

In response to the Millennium Development Goals (MDGs) and Sustainable Development Goals (SDGs) commitment, eight selected countries in the South East Asia region have made a remarkable reduction in infant and child mortality, while a few have achieved an SDG 3.2 target of 25 and 12 for child and neonatal mortality rate, respectively, well before 2030. Across these eight countries, there is a large variation in the achievement of the nine dimensions of maternal, neonatal, and child health service coverage. The poorest wealth quintiles who reside in rural areas are the most vulnerable and left behind from access to service. The rich rural residents are better off than the poor counterparts as they have financial means for travel and access to health services in urban town. The recent 2019 global Universal Health Coverage (UHC) monitoring produced a UHC service coverage index and an incidence of catastrophic health spending, which classified countries into four quadrants using global average. Countries belonging to a high coverage index and a low incidence of catastrophic spending are good performers. Countries having high coverage but also a high incidence of catastrophic spending need to improve their financial risk protection. Countries having low coverage and a high incidence of catastrophic spending need to boost service provision capacity, as well as expand financial protection. Countries having low coverage and a low incidence of catastrophic spending are the poor performers where both coverage and financial protection need significant improvement. In these countries, poor households who cannot afford to pay for health services may forego required care and instead choose to die at home. This paper recommended countries to spend adequately in the health sector, strengthen primary health care (PHC) and safeguard the poor, mothers and children as a priority in pathways towards UHC.