bluuebunny/crossref_metadata_2025 huggingface dataset:
Re-examining the New "Greeneration" behaviors: How Does the Sequential Mediation role of Green Word of Mouth and Green Trust affect Green Purchase Intention among Generation Z?
Authors: Rahmawati  , Hidayati Nur , Srinin Wathanan , Taufiqurijal Ahmad
Published: December 2024

Objective: This study explores whether and how the Z generation's perspective toward greenwashing perceptions influences their green purchasing intentions through the underlying green trust and green word of mouth.
Design/Methods/Approach: We used purposive sampling to enroll research respondents. A total of 262 Z generation respondents met the criteria, and the partial least squares technique was applied for data analysis.
Findings: Greenwashing has no significant effect on green purchase intention. However, green trust and green word of mouth significantly affect green purchase intention. We also examine the sequential mediation of green trust and green word of mouth in the relationship between greenwashing and green purchase intention and the result is significant.
Originality/Value: This research provides unique and contribution by investigating the sequential intervening effect in the greenwashing – green purchase intention relationship.
Practical/Policy implication: This article helps policymakers to develop policies that support the consumption of green products, fight greenwashing, and increase public awareness about green products. For marketers, it provides insights on how to increase green purchase intention through strategies based on word of mouth and green trust.
Digital literacy and its effect on learners’ civic engagement in adult and vocational education in Nigeria
Authors: Bessong Columbus Deku , Ewuru Agnes Awoli , Bessong Napoleon Osang , Omang Theresa Nkim , Olori Gloria Iniobong , Patrick Elizabeth Odije , Olofu Agbade Paul , Olori Christian Nwachukwu
Published: December 2024

Several works on the benefits of Information and Communication Technology (ICT) in society’s survival have been recognised by experts. However, in reality, the use of ICT in developing countries like Nigeria is still in its infancy due to their lack of knowledge about it. This study examines the effect of digital literacy on the civic engagement of learners in adult and vocational education in Nigeria. It adopted a non-equivalent control type of quasi-experimental research design involving the experimental and control groups. The sample size was 140 learners drawn from public adult and vocational education centers across Nigeria. The data-collecting instrument was the “Civic Engagement Test” (CET). Data were analysed using mean, standard deviation and analysis of covariance. Findings show that learners exposed to digital literacy had a higher positive effect on civic engagement than basic literacy. Furthermore, cooperative learning style adopted as a moderating variable had a higher civic engagement mean score than solitary. On interaction effect, the study concluded that basic literacy had a more positive effect than digital literacy, hence the need for the provision of necessary facilities to promote digital literacy skills among learners.
Pelatihan Dan Bimbingan Penyusunan Laporan Keuangan Dan Pemasaran Melalui E-Commerce Pada Amanah Sasirangan
Authors: Yuliani Rahma Yuliani , Hayat Atma , Adriani Ade , Norlena Norlena , Maharani Frista Tiara , Fitri Eka
Published: December 2024

Sasirangan merupakan budaya Kalimantan Selatan, berpotensi sebagai produk unggulan bernilai ekonomis tinggi. Dalam rangka melestarikan budaya daerah, industri kerajinan sasirangan juga dapat membuka lapangan pekerjaan untuk masyarakat sekitar. Namun, pengembangan produk industri ini masih menghadapi berbagai tantangan, salah satu usaha dengan kendala dalam kegiatan produksinya adalah Usaha Amanah Sasirangan yang pengetahuan dan keterampilannya terbatas dalam pengelolaan keuangan. Selain itu, minimnya pemanfaatan teknologi informasi, khususnya platform e-commerce, menjadi hambatan untuk menjangkau pasar yang lebih luas dan meningkatkan daya saing produk. Pengabdian ini bertujuan untuk memberikan financial experience dan digital user experience berupa pengetahuan tentang pentingnya pencatatan kegiatan usaha dan pelatihan penyusunan laporan keuangan, serta memanfaatkan pemasaran digital (e-commerce) shopee. Terdapat tiga tahapan, yaitu perencanaan, pelaksanaan, dan evaluasi. Metode yang digunakan meliputi survei, sosialisasi, pelatihan, pendampingan intensif, monitoring, dan evaluasi. Hasil pengabdian menunjukkan perubahan positif dalam persepsi mitra Amanah Sasirangan berupa peningkatan pemahaman sebesar 80% terkait pentingnya pengelolaan keuangan dan pemasaran digital (e-commerce). Kendati demikian, terdapat sejumlah kendala yang menghambat implementasi tersebut. Sumber daya manusia yang kurang kompeten di bidang akuntansi dan administrasi untuk penyusunan laporan keuangan. Selain itu, keterbatasan akses terhadap perangkat teknologi, dan infrastruktur jaringan yang kurang memadai di lokasi produksi menjadi kendala dalam pelaksanaan kegiatan pemasaran digital (e-commerce).Kata kunci; pelatihan, laporan keuangan, pemasaran digital e-commerce, sasirangan.
PEMANFAATAN SAMPAH ORGANIK RUMAH TANGGA SEBAGAI PAKAN CACING EUDRILUS EUGENIAE
Authors: Nurhaliza Silvia , Mizwar Andy
Published: December 2024

Jumlah timbulan sampah di Kota Banjarbaru pada tahun 2021 menurut data yang tercatat oleh Sistem Informasi Pengelolaan Sampah Nasional (SIPSN) sebesar 60.120 ton/tahun dengan jumlah 164,71 ton/hari yang didominasi oleh sampah organik yang bersumber dari sektor rumah tangga. Kampung Pelangi merupakan salah satu kampung sekaligus pemukiman padat penduduk yang setiap harinya menghasilkan sampah rumah tangga, salah satunya adalah sampah organik. Sampah organik tumah tangga tersebut dikumpulkan kemudian diangkut ke Tempat Pembuangan Akhir (TPA) yang mengakibatkan bertambahnya jumlah timbulan sampah organik. Salah satu upaya yang dapat dilakukan untuk mengurangi jumlah timbulan sampah organik yang berwawasan lingkungan dalam waktu yang cepat adalah dengan menjadikan sampah organik sebagai pakan cacing Eudrilus eugeniae dalam proses vermicomposting. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian pakan sampah organik rumah tangga terhadap biomassa cacing Eudrilus eugeniae. Penelitian ini dilakukan secara eksperimental selama 30 hari menggunakan Rancangan Acak Lengkap (RAL) 3 variasi perlakuan dengan 3 pengulangan. Perlakuan Dominan Buah yaitu 25% sampah sisa makanan + 25% sampah sisa sayuran + 50% sampah sisa buah pada media menunjukkan hasil paling baik untuk mendukung pertumbuhan biomassa cacing Eudrilus eugeniae. Hasil analisis menunjukkan bahwa perlakuan dengan variasi komposisi pakan tidak berbeda signifikan (P>0,05) terhadap jumlah dan bobot cacing Eudrilus eugeniae.
IDENTIFIKASI BENTUK MIKROPLASTIK DI SUNGAI MARTAPURA (STUDI KASUS: SISI BARAT MUARA KELAYAN)
Authors: Fatimah Anita
Published: December 2024

Mikroplastik adalah plastik dengan ukuran > 5 mm – 1 µm. Keberadaan mikroplastik dipengaruhi olehkegiatan manusia. Muara Kelayan adalah satu daerah yang dialiri sungai martapura yang memilikijumlah penduduk terbanyak di Banjarmasin. Penelitian ini bertujuan untuk mengidentifikasi bentukmikroplastik di air dan sedimen. Metode sampling menggunakan purposive sampling dan pengulanganmengacu pada SNI 8995 – 2021. Metode ekstraksi mikroplastik di air menggunakan KOH 10% danNaCl, metode ekstraksi di sedimen dengan pengeringan di oven suhu 70°C dan NaCl. Bentukmikroplastik diamati menggunakan mikroskop binokuler perbesaran 40x dan Sedgewick Rafter Cell(SRC) sebagai preparat. Mikroplastik yang teridentifikasi di air berbentuk fiber sebanyak 93,05%,fragmen sebanyak 4,71% dan film sebanyak 2,24%. Bentuk mikroplastik pada sampel sedimen adalahfiber sebanyak 63,95%, fragmen sebanyak 30,63%, film sebanyak 5,06% dan palet sebanyak 0,36%.
INVENTARISASI GAS EMISI RUMAH KACA YANG DIHASILKAN PT KALTIM METHANOL INDUSTRI DARI AUXILIARY BOILER DAN STACK REFORMER DENGAN METODE IPCC
Authors: Salsabila Sarah Hasna
Published: December 2024

PT Kaltim Methanol Industri adalah perusahaan penghasil methanol satu-satunya di Indonesia dalam operasinya dapat menghasilkan emisi gas rumah kaca dari auxiliary boiler dan stack reformer. Penelitian ini bertujuan untuk menghitung dan menganalisis estimasi jumlah emisi gas rumah kaca CO2 serta membandingkan dengan pengukuran alat di PT Kaltim Methanol Industri. Perhitungan emisi gas rumah kaca CO2 dilakukan dengan menggunakan metode perhitungan sesuai pedoman IPCC Guideline 2006. Hasil penelitian menunjukkan bahwa besar emisi gas emisi rumah kaca dengan perhitungan metode IPCC pada tahun 2020 hingga 2022 bertutut-turut untuk tier 1 adalah 314.567,75 ton CO2e, 279.269,49 ton CO2e dan 285.195,41 ton CO2e. Besar nilai tier 2 adalah 317.646,38 ton CO2e, 281.275,62 ton CO2e dan 286.3566,18 ton CO2e. Besar tier 3 adalah 319.283,00 ton CO2e , 283.066,04 ton CO2e dan 288.073,27 ton CO2e. Berdasarkan masing-masing nilai perhitungan yang paling mendekati dengan nilai pengukuran pada tahun 2020-2022 yaitu sama berada pada tier 3. Selisih tier 3 masing-masing tahun rentang 1-2% saja. Berdasarkan penelitian tersebut Gas Rumah Kaca di PT Kaltim Methanol Industri berbanding lurus dengan jumlah produksi methanol.
 
Kata kunci: Inventarisasi, methanol, emisi gas rumah kaca, IPCC.
Pengaruh Beban Kerja Dan Stres Kerja Terhadap Kinerja Karyawan PT. Haji Maming Alma Batulicin
Authors: Muhammad Taher  , Taharuddin
Published: December 2024

The purpose of this study was to test and find out whether there is an effect of workload and work stress on the performance of all employees in the company's work environment PT. Haji Maming Alma Batulicin. This study uses a survey method with a quantitative approach, while the population of this study are all employees who work at the company PT. Haji Maming Alma Batulicin which totaled 50 people. This study uses a total sampling technique or uses all employees as samples from the study. Data collection techniques in this study used a questionnaire with the results in the form of numbers and were analyzed using multiple linear regression. The results of this study indicate that the workload variable partially has a significant effect on employee performance, then work stress partially also has a significant effect on employee performance, and workload and work stress simultaneously have a significant effect on PT. Haji Maming Alma Batulicin
Fanaticism of K-Popers on Community Accounts and BTS- Fans on Instagram
Authors: Hanisa Hanisa , Fitriana A.Dian , Nurhakki Nurhakki
Published: December 2024

This article aims to determine the symbolic reality and subjective reality of fanatic behavior of K-Popers in editing content on community and fan accounts on Instagram. This research uses qualitative research methods and a descriptive phenomenological approach. The data collection technique is observation and interviews with K-Pop account admins on Instagram. The informants for this research are admin @yoyuby93, @agustdmine93, @yoza_anjelisa, and @asrianisj. The data was analyzed systematically through the stages of data reduction, data presentation and drawing conclusions. The results of this research show that (1) The fanatic behavior of K-Popers in editing content on the Instagram accounts of community account admins and BTS fans does not meet objective reality. Because some of the content created by the admin is the result of edits and illustrations according to his imagination, some are even not bound by the rules for creating content so the resulting content is uncontrolled and doesn't make sense. (2) The symbolic reality of the fanaticism of community account admins and BTS fans in editing content where admins always use certain symbols or elements to express their love, enjoyment, loyalty and pride towards K-Pop idols. (3) The subjective reality of the fanatic behavior of community account admins and BTS fans in editing content where the admin's feelings as a K-Pop fan influence the way he edits content because idols act as admin content ideas where they are inspired by the expressions, style and charm of their K-Pop idols.
Pengaruh Green Packaging Terhadap Green Perceived Value dan Green Perceived Risk Serta Dampaknya Pada Green Purchase Intention
Authors: Muhammad Rizki Fayad  , Hairudinor
Published: December 2024

Abstract: This research aims to test and determine the influence of green packaging on green perceived value and green perceived risk, as well to test and determine the influence of green perceived value and green perceived risk on green purchase intention. The research location was chosen at Starbucks in Banjarmasin City. A total of 100 respondents were determined and selected using accidental sampling. Questionnaries were used to collect data and PLS-SEM was used to test the hypotheses. The results show that green packaging has a significant positive effect on green perceived value and a significant negative effect on green perceived risk, also the green perceived value has a significant positive effect on green purchase intention, while green perceived risk has a significant negative effect on green purchase intention
 
Keywords: Green Packaging, Green perceived Value, Green Perceived Risk, Green Purchase Intention
Implementasi Pengadaan Barang Dan Jasa Melalui Electronic Procurement Di PT. PLN (Persero) Unit Induk Distribusi Kalimantan Selatan Dan Kalimantan Tengah
Authors: Azizah Nilna Azizah , Maryono Maryono
Published: December 2024

This study aims to identify the implementation of E-Procurement at PT PLN (Persero) South Kalimantan and Central Kalimantan Distribution Main Unit, especially the obstacles confronted. E-Procurement, which uses the internet as a means of information and communication, is expected to increase the efficiency of goods and services procurement. This research uses a qualitative approach with a focus on the implementation of E-Procurement at PT PLN (Persero) South Kalimantan and Central Kalimantan Distribution Main Unit. The data was collected through interviews, observations, documentation studies, and analyzed using the Miles and Huberman model. The results of the study found that the implementation of E-Procurement at PT PLN (Persero) South Kalimantan and Central Kalimantan Distribution Main Unit is well implemented based on indicators of quantity, quality, and timeliness. However, there are obstacles in the direct procurement process. The solution that has been done to deal with the obstacles of the implementation is to provide comprehensive counseling for Electronic Procurement users
Systematic Literature Review: Metacognitive Strategy In Science Learning
Authors: Sukaton Anggia Rose , Parlan Parlan , Widarti Hayuni Retno , Rahayu Sri , Dasna I Wayan
Published: December 2024

The purpose of this review article was to understand the application of metacognitive strategies in science education as well as identify the syntax of these strategies and their impact on the studied variable. The method used was called a systematic literature review (SLR), and it consisted of three steps: planning, carrying out, and reporting. The process of searching and filtering articles was carried out using the PRISMA method in electronic journals. Sixteen articles were relevant to the research goal and were published in twelve journals (Scopus). The results of the study indicated that students were most often used as research subjects in metacognitive strategy research. Most articles on metacognitive strategy in science learning were published in 2019, and quasi-experimental research designs were most frequently used. Chemistry is the scientific discipline that uses this strategy the most. The main metacognitive strategy syntax had three stages: planning, implementing learning, monitoring, and evaluating. The most researched metacognitive strategy has an influence on improving student learning outcomes. Therefore, metacognitive strategies could be a choice for teachers in schools to improve student learning outcomes in science. Metacognitive strategies still have great opportunities to be developed and applied in science learning in the future.
The Role of Nonverbal Communication in People with Disabilities in the Socialization of SP4N LAPOR! in Banjarbaru City
Authors: Liliana Gina , Novianti Lieta Dwi , Aulia Riska Noor
Published: December 2024

Abstract: SP4N LAPOR! is the first social media application in Indonesia that involves public participation and is two-way, so that in this application the public can interact with the government interactively. with the principle of easy and integrated for monitoring development and public services and researchers strive to bridge public participation between people with disabilities in Banjarbaru City and the South Kalimantan Provincial Government. Nonverbal communication for people with disabilities in the socialization of Sp4n LAPOR! in Banjarbaru City with the sub-issue of whether all SP4N LAPOR! platforms have been audited for accessibility for various disabilities and what has been reported regarding public services for people with disabilities in Banjarbaru City.
Keywords: SP4N LAPOR!, Social Media, Public Service, Education, Digital Literacy
NEW COMPOSITE BARKER CODES, GOLD CODES AND KASAMISEQUENCES IN BROADBAND SIGNAL SYNCHRONIZATION SYSTEMS
Authors: Maksymov Volodymyr , Gatturov Viktor , Khrapovytsky Igor
Published: December 2024

Background. Currently, noise-like signals (NLS) are widely used, which provide high noise immunity of broadband communication systems (BSS) when transmitting confidential information in an open radio channel, especially in emergency situations. Increasing the efficiency of the NSS is possible with the use of more advanced code structures, in particular, new methods for constructing Barker code sequences used in wireless communication systems with direct sequence spread spectrum technology.
Objective. The aim of the work is to study new composite codes of Barker, Gold and Kasami as synchronization signals of the BSS using simulation.
Methods. Analytical calculation methods are used, as well as simulation modelling in the MatLab software package.
Results. Modelling in the MatLab environment of new composite Barker codes, Gold codes and Kasam isequences as synchronization signals of the BSS showed that the composite sequences of Barker 49 and 77 in the range of SNR change from 0dB to 30dB are more resistant to interference compared to Kasami-63 and Gold-63 by (0,35 – 22,10)%.
Conclusions. Modelling in the MatLab software package showed a greater noise immunity of the new composite Barker codes compared to the Gold and Kasami sequenceswhen used as synchronization signals of the BSS.
METHOD OF OPERATIONAL CALCULATION OF COORDINATES OF INTERMEDIATE ROUTE POINTS OF FLYING INFORMATION ROBOT
Authors: Lysenko Olexandr , Valuiskyi Stanislav , Yavisya Valerii , Tachinina Olena , Novikov Valery , Sushin Ihor
Published: December 2024

Background. The article describes an operational calculation method of the intermediate points' coordinates of the flying information robot (FIR) route, which collects information from mobile sensors of a mobile wireless sensor network.
Objective. The purpose of the paper is to develop a method that allows building the movement trajectory of the LIR, minimizing the time for collecting information from mobile sensors.
Methods. The quickly calculating method of the route' coordinates of intermediate points involves setting a quasi-mobile mode of sensors movement and the consistent use of algorithms for solving the navigation problem, the clustering problem, and the problem of finding the flying trajectory around information collection points from mobile sensors clusters that formed at the time of the start of collecting information.
Results. A method has been developed that uses the procedures of quantitative calculation of the indicators of the structural-information connectivity of wireless sensor networks with mobile sensors. These indicators take into account the presence of not only a structural connection, but also a guaranteed information exchange between a given sender-destination pair.
Conclusions. The developed method makes it possible to improve the indicators of the structural-information connectivity of wireless sensor networks with mobile sensors: k-connectivity and network bandwidth.
MEMS-BASED WIRELESS VIBRATION TRANSDUCER FOR CONDITION MONITORING
Authors: Ivanov Sergiy , Oliinyk Pavlo
Published: December 2024

Background. When monitoring vibration of rotating machines, especially heavy ones, problems with cables of transducers often emerge. Those cables are usually long, heavy and prone to damage.
Objective. The purpose of the paper is to develop a wireless vibration transducer, which is free of those problems, on the base of MEMS accelerometer. Sensor developed should provide low power consumption, linear frequency response at least in 10…1000 Hz range, calculate vibration RMS and detect machine condition based on it.
Methods. Develop wireless sensor design based on 8-bit MCU. Develop method of MEMS frequency response correction, based on spectral analysis. Compare sensor developed with industrial piezoelectric ones.
Results. Transducer developed can be used instead of the industrial piezoelectric vibration transducers. Moreover, MEMS-based transducer allows one to move basic machine condition detection process from the high–level system to transducer level. That, in turn, allows one to reduce network traffic and simplify condition monitoring system as a whole.
Conclusions. MEMS-based wireless vibration transducer for condition monitoring is developed. Tests conducted showed that the transducer developed is well–behaved and its precision is comparable to one of industrial piezoelectric transducers.
Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma
Authors: Chen Jinyan , Li Huigang , Zhuo Jianyong , Lin Zuyuan , Hu Zhihang , He Chiyu , Wu Xiang , Jin Yiru , Lin Zhanyi , Su Renyi , Sun Yiyang , Wang Rongsen , Sun Jiancai , Wei Xuyong , Zheng Shusen , Lu Di , Xu Xiao
Published: December 2024

Pulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma (HCC) undergoing liver transplantation (LT). In addition to the common mechanisms underlying tumor metastasis, another inevitable factor is that the application of immunosuppressive agents, including calcineurin inhibitors (CNIs) and rapamycin inhibitors (mTORis), after transplantation could influence tumor recurrence and metastasis. In recent years, several studies have reported that mTORis, unlike CNIs, have the capacity to modulate the tumorigenic landscape post-liver transplantation by targeting metastasis-initiating cells and reshaping the pulmonary microenvironment. Therefore, we focused on the effects of immunosuppressive agents on the lung metastatic microenvironment and how mTORis impact tumor growth in distant organs. This revelation has provided profound insights into transplant oncology, leading to a renewed understanding of the use of immunosuppressants after LT for HCC.
TEACHINGS OF A.A. SHAKHMATOV AND V.V. VINOGRADOV ON PARTS OF SPEECH: COMPARATIVICITY
Authors:   Derzhavin Tambov State University, Sharandin A.L.
Published: December 2024

The article presents an analytical material on the parts of speech in the Russian language in the context of a comparative analysis of the grammatical teachings of A.A. Shakhmatov and V.V. Vinogradov. The object is their scientific articles, in which they critically comprehend the current state of the doctrine of parts of speech. The purpose of the article is to highlight the main similarities and differences in the approaches of these outstanding grammarians to parts of speech, given that for A.A. Shakhmatov the priority was their connection with the sentence, and for V.V. Vinogradov - with the grammatical doctrine of the word. From these positions, the analysis of the scientific views of A.A. Shakhmatov in terms of their development turns out to be theoretically significant. We analyzed topical questions about the content and volume of grammar, about the criteria for highlighting and describing parts of speech, about the ratio of parts of speech and word types. Undoubtedly, these issues are presented more systematically, consistently and are less contradictory in the works of V.V. Vinogradov. But this was largely made possible thanks to A.A. Shakhmatov, who prepared the ground for a systematic description of parts of speech, and V.V. Vinogradov carried out a qualitative shift in studying them, taking into account the critical understanding of partial theory at different stages of the development of Russian grammar. The author concludes that the grammatical arguments of A.A. Shakhmatov and V.V. Vinogradov about parts of speech are conceptually promising and testify to the theoretical and methodological significance of their views.
Advances in Fluorescence Detection Methods for the Local Generation of Hydroxyl Radicals Near DNA and Within Organelles and Membranes
Authors: Ransdell-Green Eleanor Clare , Baranowska-Kortylewicz Janina , Wang Dong
Published: December 2024

Hydroxyl radicals (•OH), the most potent oxidants among reactive oxygen species (ROS), are a major contributor to oxidative damage of biomacromolecules including DNA, lipids, and proteins. The overproduction of •OH is implicated in the pathogenesis of numerous diseases such as cancer, neurodegenerative disorders, and some cardiovascular pathologies. Given the localized nature of •OH-induced damage, detecting •OH, specifically near DNA and within organelles, is crucial for understanding their pathological roles. The major challenge of •OH detection results from their short half-life, high reactivity, and low concentrations within biological systems. As a result, there is a growing need for the development of highly sensitive and selective probes that can detect •OH in specific cellular regions. This review focuses on the advances in fluorescence probes designed to detect •OH near DNA and within cellular organelles and membranes. The key designs of the probes are highlighted, with emphasis on their strengths, applications, and limitations. Recommendations for future research directions are given to further enhance probe development and characterization.
Thermodynamic Theory of Gravity and Buoyancy
Authors: Wang Fei , Nestler Britta
Published: December 2024

There are currently four elementary forces in physics: gravity, electromagnetic force, and the weak and strong forces. In this paper, we propose a thermodynamic theory for gravity and show that the gravitational force is not an independent elementary force. We reveal that Newton’s gravitational force arises from microscopic thermodynamic potential energy. Additionally, we demonstrate that both Newton’s second law and the buoyancy force are also caused by this microscopic thermodynamic potential energy. Our calculation of the gravitational force shows a quantitative agreement with experimental data, offering a fresh perspective on gravity and buoyancy.
FINITE ELEMENT SOFTWARE FOR SOLVING THREEDIMENSIONAL PROBLEMS BY USE OF CLOUD TECHNOLOGIES
Authors: Breslavsky Dmytro , Borodin Mariia , Tatarinova Oksana , Senko Alyona
Published: December 2024

The basic relations of the Finite Element Method are presented in the paper in a general three-dimensional formulation. They are used to build a software tool designed for computational analysis of the stress-strain state using cloud resources in the case of large amounts of data. The mathematical problem statement is given. The main dependencies used to build finite element relations for an element in the form of a four-node tetrahedron are described. Linear shape functions are used. The system of linear algebraic equations is solved by the conjugate gradient method. The structure of additional programs designed for pre- and post-processing of data is discussed. Examples of the work of these programs are given, demonstrating the possibilities of analyzing finite element models, their individual fragments and the distribution of the stress-strain state components over the volume of the structural element being analyzed. The results of verification studies are discussed, which showed satisfactory reliability of the data obtained when solving elastic problems. The proposed approach for the use of cloud resources using Terraform and Kubernetes technologies, which allows performing numerical modeling using the developed software tool, is described. The characteristics of computational processes using a program for a separate personal computer and computing in the cloud are compared. It is emphasized that according to the data of the comparisons performed, it follows that the use of the Microsoft Azure infrastructure in combination with the automated tools Terraform and Kubernetes significantly accelerates the execution of the analyzed tasks. The advantage of the proposed approach in implementing the capabilities of dynamic management of system resources in accordance with the current computational load is noted.
ANALYTICAL SOLUTION OF THE INVERSE AND DIRECT KINEMATICS PROBLEM FOR THE SPATIAL ANGULAR MANIPULATOR ABB WITH SUBSEQUENT 3D MODELING
Authors: Andrieiev Yuriy , Shabanov Hennadii
Published: December 2024

This article proposes an algorithm for solving the inverse kinematics problem of a six-degree angular manipulator based on the ABB robot model. The algorithm is based on analytical derivations obtained by the authors, which consist of a sequence of expressions that allow determining all six rotation angles of the kinematic pair parts that connect the chains by a given law of movement of the output chain – the gripper. Initially, the law of its movement – functions of time of Cartesian coordinates of the pole and orientation parameters – is determined from the conditions of performing a production task by the gripper. Any point of the gripper can be chosen as the pole. Quaternion or rotation matrix can be used as orientation parameters. It is shown how a rotation matrix and quaternion can be constructed according to the laws of change of Cartesian coordinates of three gripper points. A distinctive feature of the manipulator discussed here is the presence of a common rotation axis point for the last three chains. This allows determining the law of movement of this point from the law of movement of the gripper. After which the laws of change of rotation angles of the first three chains are uniquely determined. At the same time, the orientation task of these chains is solved. To determine the angles of the last three links, a matrix or quaternion equation is compiled, based on the equivalence of two sequences of chain rotations. The first sequence is a combination of already known rotations from the third chain through the second and first chain to the absolute coordinate system and, finally, from the absolute system to the gripper. The parameters of these rotations are known. The second sequence consists of 3 rotations at unknown angles of the last three chain from the third again to the gripper. These unknown angles are determined from such an equation. The presentation of the proposed algorithm takes into account the ABB manipulator but can be applied to manipulators of the PUMA class. The algorithm is implemented using a special computer algebra system KidyM and a developed C++ program, which uses OpenGL and SolidWorks engineering graphic packet that allow 3D visualization of the calculation results.
Relación esquelética sagital y postura craneocervical en niños peruanos
Authors:   , Salazar Lara Sheyla Elsa
Published: December 2024

Introducción: La desalineación y malposición dentaria son problemas frecuente de la salud bucal. Es importante evaluar los factores asociados a la maloclusión para observar el comportamiento de la oclusión. Objetivo: Determinar la asociación de la relación esquelética sagital y la postura craneocervical. Material y Métodos: Este estudio retrospectivo evaluó 187 radiografías laterales digitales de niños peruanos (90 varones y 97 mujeres) de 6 a 12 años (edad media: 10,06 ± 1,56 años). La relación esquelética sagital incluyó el ángulo ANB según el análisis de Steiner y el ángulo IDAP (indicador de displasia anteroposterior) según el análisis de Kim en clase I (ANB 0-4°, IDAP 78-84°), clase II (ANB > 4°, IDAP < 78°) y clase III (ANB < 0°, IDAP > 84°). La postura craneocervical se evaluó con el análisis de Rocabado según el ángulo PMG-PO (rotación craneocervical) y las distancias CO-C1 (espacio suboccipital) y H (posición del hueso hioides). Las pruebas ANOVA, Kruskal-Wallis, correlación de Spearman y X2 de Pearson se utilizaron a un p < 0,05. Resultados: Una correlación muy baja a baja significativa se encontró entre el ANB con PMG-PO (rho = -0,195), CO-C1 (rho = 0,173) y H (rho = 0,173) y entre IDAP con PMG-PO (rho = 0,176) y H (rho = -0,161) (p < 0,028). Una mayor distancia H (p = 0,021) se asoció a la clase II según ADPI y un menor valor de PMG-PO (p ≤ 0,002) con rotación craneocervical posterior (47,4%) (p = 0,044) se relacionó a la clase II según ANB y ADPI, especialmente, en niñas (p ≤ 0,018). Conclusión: La postura craneocervical se asoció a la relación esquelética sagital mostrando una postura extendida en clases II frente a otras clases esqueletales...
Caracterización del uroanálisis en gatos mayores a 7 años clínicamente sanos en una clínica veterinaria de referencia en Breña, Lima - Perú, 2023 - 2024
Authors:   , Paredez Negron Silvia Denisse
Published: December 2024

El objetivo de este estudio fue describir las características del análisis físico, químico y de sedimento microscópico del uroanálisis de gatos mayores a 7 años, además de determinar asociación estadística significativa entre estas variables y los grupos etarios. Se recolectaron 100 muestras de orina por medio de cistocentesis ecoguiada de gatos a partir de 7 años que se encontraban clínicamente sanos, sin enfermedad diagnosticada y que no hubiesen recibido medicación alguna durante el desarrollo del estudio. Se consideraron las variables sexo, estado reproductivo, raza, color de orina, aspecto, densidad urinaria, pH, proteínas, glucosa, bilirrubina, sangre, cetonas, eritrocitos, leucocitos, células, tipos de células, cristales, tipos de cristales, bacterias, cilindros y levaduras. Se encontraron alteraciones dentro del análisis físico, químico y de sedimento del uroanálisis con respecto a la edad, en donde la alteración más reportada fue el número anormal de células epiteliales (>1 cel/c) con un 84% (84/100), mientras que las de tipo transicional se encontró casi en la totalidad con un 90% (90/100). Más de la mitad del grupo de felinos presentaron una densidad urinaria normal, encontrándose en un 69% (69/100). Variables como proteínas y sangre oculta fueron estadísticamente significativos con respecto a la edad. Todos los resultados para variables como cetonas y levaduras fueron negativos.
3D CoAt U SegNet-Enhanced Deep Learning Framework for Accurate Segmentation of Acute Ischemic Stroke Lesions from Non-Contrast CT Scans
Authors: Nag Manas Kumar , Sadhu Anup Kumar , Das Samiran , Kumar* Chandan , Choudhary* Sandeep
Published: December 2024

Segmentation of ischemic stroke lesions from Non-Contrast CT scans is a challenging task as ischemic stroke lesions are hypo-intense in respect to surrounding healthy brain tissue and iso-intense with lateral ventricles in many cases. Computer-assisted detection and segmentation can act as an aiding tool for clinicians. This paper proposes novel deep learning model CoAt U Segnet to detect and segment acute brain ischemic lesions from Non-Contrast CT scans (NCCT). Detection of early acute ischemic stroke lesion is challenging in NCCT scans. This treatise introduced a novel deep learning 3D model instead of common 3D segmentation models. However, most prevalent machine learning models could not obtain satisfactory detection or segmentation accuracy. 50 NCCT scans were used for training, 10 scans were used for validation, and 500 scans were used for testing the trained model. We considered dilation rates of 1, 3, and 5 in each encoder convolution block. We obtained the dice similarity score by testing on 500 unknown NCCT scans, which is calculated as 75 %, and the Jaccard index was 70%. An improved similarity index was used to segment the acute ischemic stroke lesion. The segmented lesion can be used to detect penumbra from the core area.

*Chandan Kumar and Sandeep Choudhary contributed equally.
Study protocol testing feasibility of the Comfort Measures Only Time out (CMOT) to reduce distress during palliative withdrawal of mechanical ventilation
Authors: Fischer Abigail G , Campbell Margaret L , Hayes Margaret M , Schwartzstein Richard M , White Douglas B , Mitchell Susan L , Fehnel Corey R
Published: December 2024

Distress is experienced by more than 30% of patients during palliative withdrawal of mechanical ventilation at the end of life in the intensive care unit. There is a lack of high-quality evidence for specific approaches to risk factor identification and management of distress during this process. Structured “time-outs” and checklist interventions improve surgical outcomes and have been widely adopted in procedural care, but they have not been tested for palliative use in intensive care unit settings. We describe the development and planned testing of a novel time-out checklist intervention, the Comfort Measures Only Time Out in a non-randomized single arm pilot study. Intervention development was guided by published literature and a structured inter-professional advisory panel. The intervention will be tested by clinical teams caring for 46 patients undergoing palliative withdrawal of mechanical ventilation. Nurses, physicians, advanced practice providers, and respiratory therapists will convene within an hour before withdrawal of mechanical ventilation to complete the checklist. Implementation outcomes, including feasibility, will be measured by a 12-question survey and by clinician protocol adherence. Analyses will include effect size calculation for future randomized controlled trials to test efficacy in reducing patient distress.
Trial Registration: Clinical trials.gov (NCT05861323); 16 May 2023, https://clinicaltrials.gov/study/NCT05861323?cond=NCT05861323&rank=1&tab=history&a=1#version-content-panel
Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study.
Authors: Ashworth Julie , Cornwall Nicola , Harrisson Sarah A , Woodcock Charlotte , Nicholls Elaine , Lancaster Gillian , Wathall Simon , Laing Libby , Helliwell Toby , Jowett Sue , Kigozi Jesse , Mallen Christian D , Avery Anthony , Knaggs Roger , Pincus Tamar , White Simon , Jinks Clare
Published: December 2024

Background:
Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence–based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the acceptability and feasibility of a primary care practice pharmacist-led intervention (PROMPPT review) for patients prescribed opioids for persistent pain, and the feasibility of evaluating PROMPPT in a definitive trial.
Methods:
A single arm study, with mixed methods process evaluation, was conducted in four English primary care practices. Adults prescribed opioids for ≥6months were invited to participate in the Management of Opioids and Persistent Pain (MOPP) study by completing baseline and 3-month follow-up questionnaires. Practices invited a representative sample of MOPP participants to schedule a PROMPPT review, eight of which were audio-recorded. Following the review, pharmacists completed intervention delivery templates and participants were sent an Acceptability Questionnaire and invited to consent to an interview.
Results:
Between November 2020 and May 2021, 148 participants were recruited to the MOPP study. Of these, 123 (83%) completed 3-month follow-up. Of 88 MOPP participants invited for a PROMPPT review, 80 (91%) attended. The review was rated completely acceptable or acceptable in 90% (45/50) of acceptability questionnaires returned.
Overall, participants interviewed (n=15) perceived the review as a good idea and recommended it to others; they preferred face-to-face consultations. Prior to the review, they reported mixed feelings, including feeling ‘pleased’ to be invited and ‘grateful’ someone was taking an interest, alongside concerns about what would happen during the review, including opioids being stopped and changes being detrimental. Following the review, those with a clear plan for follow-up/access to the pharmacist felt reassured about making changes to their pain medicines, whilst those advised to arrange follow-up as needed were less satisfied and more likely to report confusion about the plan.
Conclusions:
PROMPPT reviews appeared acceptable to patients, review uptake was high, and the study demonstrated the feasibility of a large definitive trial to evaluate PROMPPT. The review invitation, patient information and pharmacist training were refined based on the findings ahead of a large cluster randomised controlled trial.
Trial Registration: ISRCTN, ISRCTN87628403 Registered: 31 July 2020, https://www.isrctn.com/ISRCTN87628403
Examination of the long-term efficacy and safety of switching from entecavir to tenofovir alafenamide, including the anti-carcinogenic effect
Authors: Matsubara Takuya , Hagiwara Satoru , Nishida Naoshi , Omaru Naoya , Yoshida Akihiro , Yamamoto Tomoki , Komeda Yoriaki , Takenaka Mamoru , Kudo Masatoshi
Published: December 2024

This study evaluated the long-term efficacy and safety, as well as the anti-carcinogenic effects, of entecavir (ETV) and tenofovir alafenamide (TAF), which are widely used in Japan. The prospective observational analysis included 77 patients with chronic hepatitis B assigned to the ETV continuation and TAF change groups. After 240 weeks, the mean change in serum hepatitis B surface antigen (-0.365±0.069 log IU/mL vs. 0.301±0.039 log IU/mL, p=0.39) and estimated glomerular filtration rate (-5.407±1.660 vs. -2.666±1.52, p=0.240) did not differ significantly between the ETV and the TAF groups. Additionally, the levels of urinary β2-microglobulinβ/creatinine (2.330±0.374 at baseline vs. 2.335±0.257 at 240 weeks for ETV and 2.720±0.073 vs. 2.123±0.310 for TAF, p=0.996 and 0.455, respectively) or urinary N-acetyl-beta-D-glucosaminidase/creatinine (0.040±0.005 at baseline vs. 0.044±0.004 at 240 weeks for ETV and 0.049±0.005 vs. 0.053±0.005 for TAF, p=0.642 and 0.684, respectively) did not differ between the two groups. Finally, no significant difference was observed in the carcinogenesis inhibitory effect between the ETV and TAF groups (log-rank test, p=0.08). In conclusion, the long-term observation in the present study demonstrated the comparable efficacy and safety between ETV and TAF.
Critical aspects of droplet digital reverse transcription loop-mediated isothermal amplification (ddRT-LAMP) for viral pathogens detection
Authors: Oropeza-Ramos Laura , Pilloni Oscar , Olguin Luis , Chávez-Ramos Kenia , Trejo Frida , Salas-Navarrete Prisciluis , Ramón-Gallegos Eva , Muñoz-Medina José , Álvarez-Icaza Luis
Published: December 2024

The COVID-19 pandemic evidenced the urgent need for rapid, accurate, and scalable diagnostic methods for emerging infectious diseases. Droplet digital reverse transcription loop-mediated isothermal amplification (ddRT-LAMP) is a promising technique for pathogen detection and DNA or RNA quantification. Compared to ddPCR, it simplifies device design, reduces power consumption and analysis time, and enhances compatibility with miniaturization, making it ideal for portable, high-throughput nucleic acid detection applications. However, many parameters must be adjusted according to the application to avoid spurious results. This study critically examines key conditions for an effective ddRT-LAMP assay to quantify copies of SARS-CoV-2 N gene coded in plasmid DNA, synthetic viral RNA, or patients’ nasopharyngeal swab samples. Using a polydimethylsiloxane (PDMS) microfluidic device, the RT-LAMP reaction mixture with a fluorescent dye was divided into thousands of droplets stabilized by a surfactant in fluorinated oil. After incubation, the droplets were injected into a PDMS chamber for fluorescent imaging to determine the proportion of positive droplets and quantify the samples based on Poisson distribution. Samples with viral loads up to 102 copies/µL were quantified with high precision. Results showed that primer design and master mix composition significantly impacted the amplification. Selection of GelGreen® as the fluorescent dye was crucial, as other dyes tested diffused into the oil phase. Droplets with a diameter of around 105 µm and an incubation time of 30 min were required to achieve maximum amplification. By addressing these operational challenges, ddRT-LAMP can become a more effective tool for viral detection and quantification in clinical diagnostics.
Comparison of the correlation between cerebral [18F]FDG metabolism as assessed by two asymmetry indices and clinical neurological score in patients with ischemic cerebrovascular disease
Authors: Liang Yuxin , Cui Bixiao , Ye Linlin , Yang Bin , Shan Yi , Yang Hongwei , Ma Lei , Zhang Miao , Lu Jie
Published: December 2024

Purpose
To identify a method of assessing cerebral 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) metabolism with an asymmetry index (AI) that reflects clinical neurological function in patients with ischemic cerebrovascular disease (ICVD), and to explore its applications and potential value to the ICVD in clinical settings.
Procedures:
Seventy patients diagnosed with subacute and chronic ischemic stroke were retrospectively analyzed. All patients underwent [18F]FDG PET/MR scans and were assessed using the National Institutes of Health Stroke Scale (NIHSS) and the Modified Rankin Scale (mRS). Following a year of rehabilitation training, nineteen patients underwent a repeat [18F]FDG PET/MR scan. The decreased cerebral [18F]FDG metabolism region was defined as the AI value greater than 10%. Two voxel-wise AIs, designated as AI1 and AI2, were calculated based on the standardized uptake value ratio (SUVR). The decreased metabolism on affected side accessed by different AI calculation methods were compared. The correlations between the decreased metabolism and the clinical scores were analyzed.
Results
The volume and percentage of decreased [18F]FDG metabolism assessed by AI2 was larger than that obtained from AI1 (all p < 0.0001). The correlation coefficients between the clinical scores and the decreased metabolism in temporal and parietal lobes assessed by AI1 method were all higher than those from AI2. In addition, the improved follow-up patients showed more pronounced metabolic improvement as assessed by AI1.
Conclusions
The assessment of cerebral [18F]FDG metabolism in patients with unilateral internal carotid/middle cerebral artery steno-occlusion to reflect clinical neurological function using the AI1 method demonstrated superior performance in comparison to the AI2 method.