bluuebunny/crossref_metadata_2025 huggingface dataset:
Not Only COVID-19: Prevalence and Management of Latent Mycobacterium Tuberculosis Infection in Three Penitentiary Facilities in Southern Italy
Authors: Izzo Carmine , Monica Annunziata , De Matteis Giuseppe , De Biasi Sebastiana , De Chiara Anna , Pagano Antonio Maria , Mezzetti Eleonora , Del Duca Fabio , Manetti Alice Chiara , La Russa Raffaele , Di Paolo Marco , Maiese Aniello
Published: February 2022

Latent Mycobacterium tuberculosis infection (LTBI) and active tuberculosis in prisoners are higher than the general population and are two public health concerns, especially in low- and middle-income countries. We conducted a cross-sectional study to determine the prevalence and the factors associated with LTBI among the inmate population detained in three Southern Italian penitentiaries. Tuberculin intradermal reaction skin test was performed on the inmates who agreed to participate in the study. In case of positivity, the QuantiFERON-TB test was performed. In those positive to QuantiFERON, chest X-ray films were performed, and treatment initiated. A total of 381 inmates accepted to participate. The prevalence of LTBI was 4.2%. In the analysis, LTBI was associated with no self-reported contact with active tuberculosis patients within the prisons, and 10% of subjects admitted the use of inhaled drugs. No HIV coinfections were found. No cases of active symptomatic tuberculosis were identified during the study period. Our results confirm that incarceration increases the risk of tuberculous infection. Non-EU nationality and a history of drug addiction appear to be major risk factors for tuberculosis infection in the penitentiary setting. Reinforcing tuberculosis control is essential to prevent its transmission in prisons.
The Use of a Video-Assisted Intubating Stylet Technique in a Critically Ill and Contagious COVID-19 Patient
Authors: Yang Chih-Pin , Luk Hsiang-Ning , Qu Jason Zhensheng , Shikani Alan
Published: February 2022

Tracheal intubation and ventilatory support are among the important treatments in patients infected with COVID-19 with acute respiratory distress syndrome (ARDS) and severe hypoxia. The intubating team often uses video-assisted intubation equipment to ensure a safe and successful tracheal intubation. In this case report, we demonstrate for the first time, the use of the Shikani video-assisted intubating stylet and the Shikani intubating technique as a safe, speedy, and effective way to intubate a critically ill and highly contagious COVID-19 patient. In addition to the conventional consensus guidelines that are currently available for good practice (such as the proper use of personal protection equipment, etc.), we demonstrated that using the Shikani video-assisted intubating stylet is a reliable and proficient technique that is easy to learn while minimizing the risk of COVID-19 exposure of the airway personnel.
A Preliminary Italian Cross-Sectional Study on the Level of Digital Psychiatry Training, Knowledge, Beliefs and Experiences among Medical Students, Psychiatry Trainees and Professionals
Authors: Orsolini Laura , Bellagamba Silvia , Marchetti Virginia , Menculini Giulia , Tempia Valenta Silvia , Salvi Virginio , Volpe Umberto
Published: February 2022

The COVID-19 pandemic led to the implementation of digital psychiatry (DP), resulting in the need for a new skilled healthcare workforce. The purpose of this study was to investigate the level of training, knowledge, beliefs, and experiences of young mental health professionals and medical students in DP. An ad hoc cross-sectional survey was administered and descriptive analyses, Student’s t and ANOVA tests were conducted, together with an exploratory factor analysis, bivariate correlations and linear regression. Most of the sample (N = 239) declared that DP was never discussed within their academic training (89.1%), mainly revealing an overall lack of knowledge on the issue. Nevertheless, subjects mostly declared that DP represents a valuable therapeutic tool in mental health (80%) and that their training should include this topic (54.4%). Moreover, most subjects declared that digital interventions are less effective than face-to-face ones (73.2%), despite the emerging evidence that being trained in DP is significantly associated with the belief that digital and in-person interventions are comparable in their effectiveness (p ≤ 0.05). Strong positive correlations were found between the knowledge score (KS) and perceived significance index (PSI) (r = 0.148, p < 0.001), and KS and Digital Psychiatry Opinion (DPO) index (r = 0.193, p < 0.001). PSI scores statistically significantly predicted KS total scores (F(1, 237) = 5.283, R2 = 0.022, p = 0.022). KS scores statistically significantly predicted DPO total scores (F(1, 237) = 9.136, R2 = 0.037, p = 0.003). During the current pandemic, DP represented an ideal response to the forced physical distancing by ensuring the advantage of greater access to care. However, this kind of intervention is still uncommon, and mental health professionals still prove to be skeptical. The lack of formal training on DP during the academic years could be a limiting factor.
Smartphone-Based Visual Inspection with Acetic Acid: An Innovative Tool to Improve Cervical Cancer Screening in Low-Resource Setting
Authors: Sami Jana , Lemoupa Makajio Sophie , Jeannot Emilien , Kenfack Bruno , Viñals Roser , Vassilakos Pierre , Petignat Patrick
Published: February 2022

Visual inspection with acetic acid (VIA) is recommended by the World Health Organization for primary cervical cancer screening or triage of human papillomavirus-positive women living in low-resource settings. Nonetheless, traditional VIA with the naked-eye is associated with large variabilities in the detection of pre-cancer and with a lack of quality control. Digital-VIA (D-VIA), using high definition cameras, allows magnification and zooming on transformation zones and suspicious cervical regions, as well as simultaneously compare native and post-VIA images in real-time. We searched MEDLINE and LILACS between January 2015 and November 2021 for relevant studies conducted in low-resource settings using a smartphone device for D-VIA. The aim of this review was to provide an evaluation on available data for smartphone use in low-resource settings in the context of D-VIA-based cervical cancer screenings. The available results to date show that the quality of D-VIA images is satisfactory and enables CIN1/CIN2+ diagnosis, and that a smartphone is a promising tool for cervical cancer screening monitoring and for on- and off-site supervision, and training. The use of artificial intelligence algorithms could soon allow automated and accurate cervical lesion detection.
Spatial Healthcare Accessibility: A District-Level Analysis of Travel for Outpatient Diabetology in Czechia
Authors: Šídlo Luděk , Maláková Kateřina
Published: February 2022

Assessments of regional differences in the accessibility and capacity of health services often rely on indicators based on data from the permanent residents of a given region. However, a patient does not always use health services in their place of residence. The objective of this article is to evaluate the influence of spatial healthcare accessibility on regional differences in the provision and take-up of health services, using outpatient diabetology in Czechia as a case study. The analysis is grounded in monitoring the differences in the patient’s place of residence and the location of the healthcare provided. Anonymized individual data of the largest Czech health insurance company for 2019 are used (366,537 patients, 2,481,129 medical procedures). The data are aggregated at the district level (LAU 1). It has been identified that regions where patients travel outside their area of residence to access more than half of their healthcare needs are mostly in local/regional centres. Moreover, these patients increase the number of medical services provided in local/regional centres, often by more than 20%, which has been reflected in greater healthcare capacity in these centres. To assess regional differences, it is important to take the spatial healthcare accessibility into account and also consider why patients travel for healthcare. Reasons could be the insufficient local capacity, varied quality of health services or individual factors. In such cases, healthcare actors (health insurance companies, local government etc.) should respond to the situation and take appropriate action to reduce these dissimilarities.
Can Social Media Profiles Be a Reliable Source of Information on Nutrition and Dietetics?
Authors: Kabata Paweł , Winniczuk-Kabata Dorota , Kabata Piotr Maciej , Jaśkiewicz Janusz , Połom Karol
Published: February 2022

Background: Social media are growing worldwide platforms for unlimited exchange of various content. Owing to their accessibility and short form, they can be utilized as usable, wide-range communication and information tools for companies, scientific communities, patient advocacy organizations, and special interest groups. This study aimed to investigate whether Instagram® profiles can be reliable sources of information and knowledge about nutrition and dietetics. Materials and Methods: Random identification of nutrition-related posts was performed using a built-in website search engine. Posts were searched by five popular hashtags: #nutrition, #nutritionist, #instadiet, #diet, and #dietitian, 250 newest posts of each. Advertisement posts were discarded. Each eligible post was then categorized (dietetics, fitness, motivation, other) and assessed with regard to the quality of nutrition information provided (five levels from none to good quality), popularity (number of followers, likes, and comments), and engagement measures (like, comment, and engagement ratio). Results: A total of 1189 posts were reviewed. The overall quality of the content regarding nutritional knowledge was extremely low (93.9% of all posts), also when divided into categories. Among all posts, 63.8% were categorized as “nutrition and dietetics”, while “fitness”, “motivation”, and “other” categories comprised 8.2%, 4.8%, and 23.2% of the posts, respectively. Posts recognized as dietetics were the most liked (mean n = 116 likes per post) and of the highest quality. However, those motivational raised the greatest degree of engagement (32.7%). Posts with cooking recipes were the most commented. Conclusions: Random post search cannot provide viewers with valuable nutrition information. A dedicated search for high-quality professional profiles is preferred to obtain quality information.
A Win–Win Situation: Performance and Adaptability of Petite Sweetpotato Production in a Temperate Region
Authors: Duque Luis O. , Sánchez Elsa , Pecota Kenneth , Yencho Craig
Published: February 2022

New-found interest in sweetpotato production in the Mid-Atlantic and Northeastern U.S. has been steadily increasing in the last several years. Sweetpotatoes are usually grown for fresh market use and novel marketing strategies and new consumer niches are providing farmers options of growing new sweetpotato varieties with exciting colors and flavor profiles that are adapted to the Mid-Atlantic and Northeastern U.S. Petite sweetpotatoes have gained market attention because they are easier to handle and faster to cook compared to U.S. No. 1 storage roots. The goal of this research was to determine the performance and adaptableness of eight commercial sweetpotato varieties and two unreleased accessions for U.S. No.1 and Petite sweetpotato production under black plastic mulch tailored for the mild temperate growing conditions of the Mid-Atlantic and Northeastern U.S. Two in-row spacings (15 cm and 30 cm) and two harvest dates (90 and 120 days after planting, DAP) were evaluated during the 2018 and 2019 growing seasons. Our results showed that the ideal harvest time is at least 120 DAP compared to an early harvest at 90 DAP as there was a 2-fold difference in marketable yield at both 15 and 30 cm in-row spacing with marketable yield between 20 and 54 t ha−1. ‘Averre’ and ‘Beauregard’ produced the highest U.S. No. 1 and Petite yields under both in-row spacing treatments harvested at 120 DAP for both years evaluated, though the general effect of in-row spacing and DAP interaction (separate years) on yield performance was cultivar specific. We also found that growing degree days is a better predictor for harvest than days after planting, with an accumulation of at least ~700 GDD (base temperature 15.5 °C) or ~1300 GDD (base temperature 10 °C) for both U.S. No. 1 and Petite roots. Additional studies are required to identify the stability of cultivars tested and treatments imposed with environmental interactions in this region. In addition, there is an urgency for updated sweetpotato management practices exclusively designed for sweetpotato varieties for the Mid-Atlantic and Northeastern U.S.
Preliminary Effectiveness of mHealth App-Based Pelvic Floor Muscle Training among Pregnant Women to Improve Their Exercise Adherence: A Pilot Randomised Control Trial
Authors: Jaffar Aida , Mohd Sidik Sherina , Foo Chai Nien , Muhammad Noor Azimah , Abdul Manaf Rosliza , Suhaili Nazhatussima
Published: February 2022

This pilot randomised control trial (RCT) aimed to evaluate the feasibility and preliminary effectiveness of conducting a full-powered trial for a newly developed pelvic floor muscle training (PFMT) app among pregnant women with urinary incontinence (UI) in Malaysia. This was a prospective, single-centre, single-blind, parallel, randomised controlled, pilot feasibility study—the Kegel Exercise Pregnancy Training app (KEPT app) trial. In total, 26 pregnant women with urinary incontinence from an urban healthcare clinic were recruited and randomly assigned to either intervention or waitlist control group. The intervention group received the KEPT app, while the control group received usual antenatal care (waitlist control). Of the 26 pregnant women, 16 (61.5%) completed the two-month follow-up. The recruitment rate was 54.2%, and the retention rate was 62.5% in the intervention group and 60% in the control group. There was a significant difference between intervention and control groups’ baseline measurement in the severity of UI (p = 0.031). The app improved their knowledge (p = 0.011) and self-efficacy (p = 0.038) after the first month and attitude (p = 0.034) after two months of intervention, compared with the control group. This study supports the feasibility of our future cluster RCT. The KEPT app demonstrates a promising effect in improving PFMT attitude and self-efficacy and potentially enhancing exercise adherence among pregnant women with UI. Trial registration: This study was prospectively registered on ClinicalTrials.gov on 19 February 2021 (NCT04762433).
Inequity in the Access to eHealth and Its Decomposition Case of Poland
Authors: Rój Justyna
Published: February 2022

The aim of this research is to analyze the disparities in the distribution of information and communication technologies and skills across geographically determined population groups and to identify the source of the inequity. Literature showed that the nature of e-Health has the potential to resolve health inequalities. However, its successful implementation depends on such factors as the accessibility of required technologies to all people, the existence of technical infrastructure as well as people having the necessary information and communication skills. Employment of the Theil index allowed us to measure and decompose the national inequality into both: between and within macro-regions differences. Data was collected from Statistics Poland. The results showed the existence of inequity and its drivers. The novelty of this research results from application of the Theil index in the field of eHealth and identification of the barrier in access to e-Health, which can be a basis for improvement in government policy.
What Should Be Considered When Evaluating the Quality of Home Care? A Survey of Expert Opinions on the Evaluation of the Quality of Home Care in Japan
Authors: Jeong Seungwon , Inoue Yusuke , Arai Yasuyuki , Ohta Hideki , Suzuki Takao
Published: February 2022

Intending to obtain scientific evidence to use in developing indicators for evaluating the quality of home care, we surveyed doctors, nurses, and other home care professionals to determine the points they consider to be essential in evaluating home care. We investigated all 901 clinics registered to the National Association of Medical Institutions Supporting Home Care and a random sample of 600 Visiting Nurse Service stations registered to the National Association for Visiting Nurse Service in Japan. A total of 539 questionnaire responses were received (response rate: 35.9%). In this study, a factor analysis revealed four factors to be considered when evaluating the quality of home care: (1) patients’ and family members’ level of satisfaction, (2) home care process, (3) structure of home care, and (4) medical outcomes. The factor of the satisfaction of patients and family members identified in the present study was not considered in previous studies for evaluating the quality of care in Japan. Satisfaction is the point of difference in goals between hospital-based care and home care, and it requires different measurement indicators. Home care professionals expect to help relieve the physical and psychological burden felt by the patient and their family. Thus, on the evaluation indicators of quality of home care, their perspectives from the present study are valuable.
Disparities in Excess, All-Cause Mortality among Black, Hispanic, and White Veterans at the U.S. Department of Veterans Affairs during the COVID-19 Pandemic
Authors: Lukowsky Lilia R. , Der-Martirosian Claudia , Dobalian Aram
Published: February 2022

Background: From 2019 to 2020, all-cause mortality in the U.S. increased, with most of the rise attributed to COVID-19. No studies have examined the racial disparities in all-cause mortality among U.S. veterans receiving medical care (VA users) at the U.S. Department of Veterans Affairs (VA) during the pandemic. Methods: In the present paper, we conduct a longitudinal study examining the differences in mortality among White, Black, and Hispanic veterans, aged 45 years and older, during the first, full year of the pandemic (March 2020–February 2021). We calculated the Standardized Mortality Rates (SMRs) per 100,000 VA users for each racial and ethnic group by age and gender. Results: The highest percentage increase between the number of deaths occurred between pre- and post-pandemic years (March 2020–February 2021 vs. March 2019–February 2020). For Hispanics, the all-cause mortality increased by 34%, while for Blacks, it increased by 32%. At the same time, we observed that an 18% increase in all-cause mortality occurred among Whites. Conclusion: Blacks and Hispanics were disproportionately affected by the COVID-19 pandemic, leading both directly and indirectly to higher all-cause mortality among these groups compared to Whites. Disparities in the all-cause mortality rates varied over time and across groups. Additional research is needed to examine which factors may account for the observed changes over time. Understanding those factors will permit the development of strategies to mitigate these disparities.
Factors Associated with Tooth Loss in General Population of Bialystok, Poland
Authors: Gabiec Katarzyna , Bagińska Joanna , Łaguna Wojciech , Rodakowska Ewa , Kamińska Inga , Stachurska Zofia , Dubatówka Marlena , Kondraciuk Marcin , Kamiński Karol Adam
Published: February 2022

Background: The aim of this study was to assess risk factors for tooth loss in the population of the city of Bialystok, in north-eastern Poland, taking into account the entire population and different age groups. The study included 1138 subjects divided into three subgroups: 20–44 years, 45–64 years, and 65–79 years. Participants were classified according to the number of teeth lost (0–8 vs. 9–28). Socio-economic variables, smoking history, and dental habits were collected through a questionnaire. Medical examinations provided data on the body mass index and the fasting blood glucose level. Data were statistically analysed using Mann-Whitney U, Student’s t, chi2 tests, and binary logistic regression, p < 0.05. Results: For the general population, being female (OR 1.38, 1.07–1.79, p = 0.015), having secondary education (OR 4.18, Cl 2.97–5.87, p < 0.000), higher body mass index (OR 1.13, Cl 1.10–1.17, p < 0.000), higher fasting blood glucose level (OR 1.03 1.03–1.04, p < 0.000), being former smoker (OR 1.72, Cl 1.29–2.31, p < 0.000), ever smoker (OR 1.69, Cl 1.29–2.20, p < 0.000), current smoker (OR 1.62, Cl 1.15–2.29, p < 0.006), longer smoking period (OR 1.11, Cl 1.09–1.14, p < 0.000), last visit to the dentist over a year ago (OR 1.92, Cl 0.44–2.58, p < 0.000) and tooth brushing less than two times a day (OR 1.6, Cl 1.14–2.23, p < 0.006) were associated with losing more than 8 teeth. In the subgroup aged 20–44 years, only smoking duration was a risk factor for tooth loss (p = 0.02). For the middle-aged and oldest groups, education level (respectively p < 0.001, and p = 0.001), body mass index (respectively, p < 0.001, and p = 0.037), smoking status ever/former/current (respectively p < 0.001 and p = 0.002), smoking status never/ever (respectively p < 0.001 and p = 0.009), smoking duration (p < 0.001) were related to tooth loss. Additionally, in the elderly group, fasting blood glucose level (p = 0.044) and frequency of dental visits (p = 0.007) were related to tooth loss. We concluded that in the evaluated population, tooth loss was associated with socio-demographic, medical, and behavioural factors.
Differential Metabolites and Metabolic Pathways Involved in Aerobic Exercise Improvement of Chronic Fatigue Symptoms in Adolescents Based on Gas Chromatography–Mass Spectrometry
Authors: Zhao Shanguang , Chi Aiping , Wan Bingjun , Liang Jian
Published: February 2022

Studies have found that the prevalence of chronic fatigue syndrome (CFS) in adolescents has continued to increase over the years, affecting learning and physical health. High school is a critical stage for adolescents to grow and mature. There are inadequate detection and rehabilitation methods for CFS due to an insufficient understanding of the physiological mechanisms of CFS. The purpose of this study was to evaluate the effect and metabolic mechanisms of an aerobic running intervention program for high school students with CFS. Forty-six male high school students with CFS were randomly assigned to the exercise intervention group (EI) and control group (CFS). Twenty-four age- and sex-matched healthy male students were recruited as healthy controls (HCs). The EI group received the aerobic intervention for 12 weeks, three times a week, in 45-min sessions; the CFS group maintained their daily routines as normal. The outcome measures included fatigue symptoms and oxidation levels. Keratin was extracted from the nails of all participants, and the oxidation level was assessed by measuring the content of 3-Nitrotyrosine (3-NT) in the keratin by ultraviolet spectrophotometry. All participants’ morning urine was collected to analyze urinary differential metabolites by the GC-MS technique before and after the intervention, and MetaboAnalyst 5.0 was used for pathway analysis. Compared with before the intervention, the fatigue score and 3-NT level in the EI group were significantly decreased after the intervention. The CFS group was screened for 20 differential metabolites involving the disruption of six metabolic pathways, including arginine biosynthesis, glycerolipid metabolism, pentose phosphate pathway, purine metabolism, β-alanine metabolism, and arginine and proline metabolism. After the intervention, 21 differential metabolites were screened, involved in alterations in three metabolic pathways: beta-alanine metabolism, pentose phosphate metabolism, and arginine and proline metabolism. Aerobic exercise was found to lessen fatigue symptoms and oxidative levels in students with CFS, which may be related to the regulation of putrescine (arginine and proline metabolism), 6-Phospho-D-Gluconate (starch and sucrose metabolism pathway), and Pentose (phosphate metabolism pathway).
The Her Tribe and His Tribe Aboriginal-Designed Empowerment Programs
Authors: Gee Graham , Sheridan Sarah , Charles Lena , Dayne Lana , Joyce Lisa , Stevens Jack , Paradies Yin , Hulbert Carol , Haslam Nick , Thorpe Reg , Thorpe Lisa , Thorpe Alister , Stewart Paul , Austin Lionel , Lyons Louise , Belfrage Mary , Warber Ruby , Paxton Ashley , Thompson Laura
Published: February 2022

This study documents evaluation of the Her Tribe and His Tribe Aboriginal-designed empowerment pilot programs. The programs were designed to support Victorian Aboriginal people to strengthen mental health, social and emotional wellbeing, community connection, and to reduce psychological distress. A second aim was to explore participants’ experiences of the programs, including the feasibility and acceptability of the evaluation component. Her Tribe ran for 16 weeks and His Tribe for 12 weeks. In total, 43 women and 26 men completed assessments at pre- and post-program completion, and 17 and 10, respectively, participated in yarning circles at the 6-month follow up. For both programs, there were significant increases in participants’ access to personal strengths and resources, relationship–community–cultural strengths and resources, and decreases in psychological distress. These changes were associated with small to moderate effects that were maintained at the 6-month follow up. There was a significant increase in aerobic fitness for female but not male participants, and no significant changes in weight for either group. Participants described a range of benefits from the programs, including positive elements and areas for improvement. They also viewed the evaluation as feasible and acceptable, and the findings of value. The outcomes from both pilot programs provide evidence that Aboriginal-designed programs, with a focus on physical and cultural activities, can help to strengthen mental health and wellbeing, community connection, and reduce psychological distress in Victorian Aboriginal communities.
Attribution Assessment and Prediction of Runoff Change in the Han River Basin, China
Authors: Wei Mengru , Yuan Zhe , Xu Jijun , Shi Mengqi , Wen Xin
Published: February 2022

The ecological environment and water resources of the Han River Basin (HRB) are incredibly susceptible to global warming. Naturally, the analysis of future runoff in HRB is believed to offer a theoretical basis for water resources management and ecological protection in HRB. The purpose of this study is to investigate and forecast the effects of climate change and land use change on runoff in the HRB. This study uses CMIP6 data to simulate three future climate change scenarios (SSP126, SSP245 and SSP585) for changes in precipitation and temperature, a CA-Markov model to simulate future land use change scenarios, and the Budyko framework to predict future runoff changes. The results show that: (1) Between 1974 and 2014, annual runoff (R) and annual precipitation (P) in the HRB decline not so significantly with a rate of 1.3673 mm/a and 1.2709 mm/a, while maximum temperature (Tmax) and minimum temperature (Tmin) and potential evapotranspiration (E0) show a non-significantly increasing trend with 0.0296 °C/a, 0.0204 °C/a and 1.3313 mm/a, respectively. Precipitation is considered as main contributor to the decline in Han River runoff, accounting for 54.1%. (2) In the HRB, overall precipitation and temperature are estimated to rise in the coming years, with all other hydrological variables. The comparison of precipitation rise under each scenario is as follows: SSP126 scenario > SSP585 scenario > SSP245 scenario. The comparison of the temperature increase under each scenario is as follows: SSP585 scenario > SSP245 scenario > SSP126 scenario. (3) In the HRB, farmland and grassland land will continue to decline in the future. The amount of forest acreage is projected to decline but not so significantly. (4) The future runoff of the HRB shows an increasing trend, and the future runoff varies in different scenarios and periods. Under the land use scenarios of maintaining LUCC1992–2014 and LUCC2040 and LUCC2060, the R change rates in 2015–2040 are 8.27–25.47% and −8.04–19.35%, respectively, and the R in 2040–2060 are 2.09–13.66% and 19.35–31.52%. At the same time, it is very likely to overestimate the future runoff of the HRB without considering the changes in the land use data of the underlying surface in the future.
Is Being Physically Active Enough or Do People with Parkinson’s Disease Need Structured Supervised Exercise? Lessons Learned from COVID-19
Authors: Domingos Josefa , Família Carlos , Fernandes Júlio Belo , Dean John , Godinho Catarina
Published: February 2022

Social isolation imposed by the COVID-19 pandemic negatively impacted people’s lifestyles and daily activities. In this work we compared pre- and post-pandemic clinical outcomes in people with Parkinson’s disease, to assess differences according to the type of behaviour and exercise habits adopted by participants. After two months of COVID-19 lockdown, we assessed: changes in exercise behaviour; motor and non-motor aspects of daily life experiences (MDS-UPDRS I & II); activities of daily living (The Schwab & England scale); quality of life (Parkinson Disease Questionnaire); sleep (Parkinson Disease Sleep Scale); falls; and Clinical Global Impression Change. Twenty-seven individuals aged between 57 and 92 years old participated; from these, ten individuals (37%) completely interrupted physical activities, while seventeen (63%) maintained some level of active lifestyle. Regardless of whether they remained active or not, all participants perceived a significant worsening of their clinical condition, reporting an increase in difficulties completing daily activities or chores (37%) and worsening of their health condition (51.8%). The quantifiable influence of exercise habits was borderline for the group who kept active. The active group seem to have a better self-perception of their health condition, although it was not enough to show a clear benefit. People with Parkinson’s disease should be informed that being physically active may not be enough and more structured exercise could be needed.
An Exploration of Nutritional Education within the Holiday Activities and Food Programme in England
Authors: Round Emily K. , Shinwell Jackie , Stretesky Paul B. , Defeyter Margaret Anne
Published: February 2022

Nutritional education is a recent, mandatory inclusion within the quality standards framework for the Holiday Activities and Food (HAF) programme in England; funded by the Department for Education (DfE). Whilst research has been conducted regarding nutritional education in other contexts, such as schools and community organisations, to the authors’ knowledge, no published research has yet explored nutritional education within HAF. The current study therefore aimed to explore the implementation, delivery, and perceived facilitators, barriers and impacts of nutritional education across a number of Local Authorities delivering HAF in England. Purposive sampling (n = 11) was used to recruit HAF leads involved in nutritional education, to participate in semi-structured interviews. Thematic analysis showed that nutritional education is currently delivered through a variety of modes including face-to-face, online, and take-home methods, all of which require a range of considerations in terms of implementation, delivery, and associated impacts, with some holiday clubs offering no nutritional education. According to participating HAF leads, nutritional education was used as a mechanism to enhance children’s and parents’ cooking confidence and competence, to improve dietary intake, and to increase understanding of issues such as food sustainability, environmental impacts, and food provenance. Although there are many examples of innovative practice, the findings suggested that COVID guidelines proved challenging for providers to include nutritional education within HAF delivery during 2021. Further, whilst the quality standards framework for nutritional education provides flexibility in terms of implementation and delivery, specific guidance, and monitoring of provision is required to ensure quality assurance and consistency across the HAF programme.
Seroprevalence of SARS-CoV-2 Antibodies in Employees of Three Hospitals of a Secondary Care Hospital Network in Germany and an Associated Fire Brigade: Results of a Repeated Cross-Sectional Surveillance Study Over 1 Year
Authors: Hildebrandt Anke , Hökelekli Oktay , Uflacker Lutz , Rudolf Henrik , Paulussen Michael , Gatermann Sören G.
Published: February 2022

Healthcare workers (HCWs) are playing a vital role in the current SARS-CoV-2 pandemic. This study investigated how infection spreads within three local hospitals and an associated fire brigade in Germany by testing employees for the presence of SARS-CoV-2 IgG antibodies over one year. The three observational periods corresponded to the initial three pandemic waves: first wave: June–September 2020, second wave: October 2020–January 2021, and third wave: February–June 2021. We analysed 3285 serum samples of 1842 employees, which represents 65.7% of all employees. Altogether, 13.2% employees were seropositive: 194/1411 HCWs (13.7%) and 49/431 non-HCWs (11.4%) with a clear increase of seroprevalence from the first (1.1%) to the second (13.2%) and third (29.3%) pandemic wave. HCWs presumably had an additional occupational risk for infection in the second and third wave due to an increase of infection pressure with more COVID-19 patients treated, showing possible weak points in the recommended infection prevention strategy.
Harsh Parenting and Children’s Aggressive Behavior: A Moderated Mediation Model
Authors: Liu Bowen , Yang Yuhua , Geng Jie , Cai Tingting , Zhu Mengjuan , Chen Tao , Xiang Jinjing
Published: February 2022

Harsh parenting and its effect on children’s aggressive behavior has received attention from researchers, however few studies have considered the role of the emotional process. This study aims to examine the relationship between harsh parenting, children’s aggressive behavior, normative beliefs about aggression, and regulatory emotional self-efficacy, alongside their mechanism of interplay. A sample of 235 senior primary school students in Beijing were recruited as participants by using the Harsh Parenting Scale, the Normative Beliefs about Aggression Scale, the Buss–Warren Aggression Questionnaire, and the Regulatory Emotional Self-Efficacy Scale. Results indicated that: (1) Harsh parenting had a significant positive predictive effect on children’s aggressive behavior after controlling gender; (2) normative beliefs about the aggression of children mediated the relationship between harsh parenting and children’s aggressive behavior; and (3) regulatory emotional self-efficacy had moderating effects both the mediation model of normative beliefs about the aggression of children and in the direct predictive model of harsh parenting on children’s aggressive behavior. The results are not only helpful to understand the relationship between harsh parenting and children’s aggressive behavior from the perspective of an integrated model of emotion processes and cognition, but also provide a new practical way to prevent and intervene in children’s aggressive behavior in the future.
Relationship between Personality and Mortality among Japanese Older Adults: A 14-Year Longitudinal Study
Authors: Iwasa Hajime , Inagaki Hiroki , Masui Yukie , Gondo Yasuyuki
Published: February 2022

Personality is one of the fundamental factors in determining longevity. We used a 14-year mortality surveillance to investigate the relationship between the Big Five personality traits and all-cause mortality among older adults dwelling in a Japanese community. Individuals over 65 years old (484 males and 743 females) were recruited for the study. We used the NEO Five-Factor Inventory to assess the Big Five personality traits: neuroticism, extraversion, openness, agreeableness, and conscientiousness. During the follow-up period, 502 persons (250 men and 252 women) had died. Cox proportional hazards regression controlling for covariates showed that extraversion (hazard ratio [HR] = 0.783, 95% confidence interval [CI] = 0.636 to 0.965 and HR = 0.757, 95% CI = 0.607 to 0.944 for the middle and highest tertiles, respectively), openness (HR = 0.768, 95% CI = 0.608 to 0.969 for the highest tertile), and conscientiousness (HR = 0.745, 95% CI = 0.607 to 0.913 and HR = 0.667, 95% CI = 0.530 to 0.840 for the middle and highest tertiles, respectively) were inversely associated with mortality when the five traits were analyzed separately. Our findings suggest that older adults who have a higher level of either extraversion, openness, or conscientiousness are more likely to live longer.
Did COVID-19-Related Alcohol Sales Restrictions Reduce Alcohol Consumption? Findings from a National Online Survey in South Africa
Authors: Theron Marieke , Swart Rina , Londani Mukhethwa , Parry Charles , Petersen Williams Petal , Harker Nadine
Published: February 2022

Background: South Africa has a high prevalence of heavy episodic drinking (HED). Due to the high levels of alcohol misuse and violence, public hospital intensive care units were often overrun during the COVID-19 pandemic. This research investigated alcohol intake behaviour change during differing levels of lockdown restrictions, which included bans on alcohol sales. Methods: A self-reported Facebook survey ran from July to November 2020. The questions included socio-demographics, income, alcohol intake, purchasing behaviour, and reasoning. Chi-square tests/Fisher’s exact test for categorical data, Student’s t-test for normal continuous data, and the Mann–Whitney U test for non-normal data were applied. Multiple logistic regression was run for HED versus moderate drinkers. Results: A total of 798 participants took part in the survey, of which 68.4% were female. Nearly 50% of participants fell into the HED category and the majority bought alcohol illegally during restrictions. HED respondents who drank more alcohol than usual during restrictions reported that they felt stressed, needed to relax, and were bored. Conclusions: Policies intended to increase the pricing of alcohol may have the potential to reduce alcohol intake. Reducing stress and anxiety may be key to curtailing HED during emergency situations.
Internalized Sexual Stigma among Lesbian, Gay, and Bisexual Individuals in Taiwan: Its Related Factors and Association with Mental Health Problems
Authors: Lee Jia-In , Chang Yu-Ping , Tsai Ching-Shu , Yen Cheng-Fang
Published: February 2022

Internalized sexual stigma (ISS) is one of the major issues that can compromise the health of sexual minority populations. This quantitative study aimed to examine: (1) the relationships of individual factors (gender, age, education level, sexual orientation, and age of identification of sexual orientation) and perceived family support with ISS; and (2) the associations of ISS with mood problems and the moderating effects of gender on the associations among Taiwanese young adult lesbian, gay, and bisexual (LGB) individuals. In total, 500 male and 500 female young adult LGB individuals aged between 20 and 30 years participated in this study. The experience of ISS, individual (e.g., gender, age, education level, sexual orientation, and age of identification of sexual orientation) and environmental factors (perceived family), mood problems (e.g., anxiety and depression) were collected. The individual and environmental factors related to ISS and the associations of ISS with mood problems were examined using multivariate linear regression analysis. The results indicated that gender, sexual orientation, age of identification of sexual orientation, and perceived family support were significantly associated with all or some dimensions of ISS in LGB individuals. Various dimensions of ISS had different relationships with anxiety and depression. Gender had moderating effects on the association between the identity dimension of ISS and sexual orientation as well as between the social discomfort dimension of ISS and anxiety. Various dimensions of ISS among LGB individuals should be routinely assessed by mental health service units. Intervention programs should be provided for LGB individuals, especially those with factors related to ISS.
Alcohol Use and Gambling Associated with Impulsivity among a Swedish University Sample
Authors: Forsström David , Rozental Alexander , Sundqvist Kristina
Published: February 2022

Excessive alcohol use and gambling can have negative consequences. Across countries, the risk of excessive alcohol use is more common in university populations than in the general population. However, few studies have investigated the prevalence of both alcohol use and gambling in this group. This study explores these behaviours in a Swedish university setting. In addition, this study investigates how impulsivity affects alcohol use and gambling. In total, 794 Swedish students answered an online survey. Data were analysed using descriptive statistics to determine prevalence, and multinomial logistic regression was used to determine the contribution of impulsivity, age, and sex to alcohol use and gambling. Compared to the Swedish national prevalence, the prevalence was higher for excessive alcohol use, but the prevalence of gambling was at the same level or lower. High levels of impulsivity and male sex increased the risk of excessive alcohol use, while older age lowered the risk of excessive alcohol use and gambling. The results indicate that primarily young men could benefit from primary prevention in a university setting. Also, screening for impulsivity in men might be one way to identify risk groups in a university population.
Space-Time Dynamics of Land Use in the Municipality of Goianésia Do Pará, Brazil
Authors: Velastegui-Montoya Andrés , Lima Aline de , Adami Marcos
Published: February 2022

Hydroelectric energy generates more than 50% of all renewable electricity in the world. The Amazon is home to a large part of these ventures, promoted as a strategy of energy independence in order to reduce greenhouse gas emissions in the countries of the region. However, these hydroelectric plants lead to changes in land cover, fragmentation, degradation, and loss of tropical forests. This article analyzes the spatial pattern of alterations in the land cover of the municipality of Goianésia do Pará, one of the seven municipalities affected by the artificial lake of the Tucuruí hydroelectric plant. This case study integrates remote sensing and landscape metrics to identify, quantify, and spatialize the loss of tropical forest within the municipality by using satellite images of the TM-Landsat 5, ETM+-Landsat 7 and OLI-Landsat 8 sensors. The results show that the average deforestation rates were high in the first two periods: 1984–1988 (23,101.2 ha per year) and 1988–1999 (13,428.6 ha per year). However, this rate drastically fell in the last period because, by 2010, more than 60% of the territory was already deforested, which shows the consolidation of the municipality’s deforestation process.
Language Modeling on Location-Based Social Networks
Authors: Diaz Juglar , Bravo-Marquez Felipe , Poblete Barbara
Published: February 2022

The popularity of mobile devices with GPS capabilities, along with the worldwide adoption of social media, have created a rich source of text data combined with spatio-temporal information. Text data collected from location-based social networks can be used to gain space–time insights into human behavior and provide a view of time and space from the social media lens. From a data modeling perspective, text, time, and space have different scales and representation approaches; hence, it is not trivial to jointly represent them in a unified model. Existing approaches do not capture the sequential structure present in texts or the patterns that drive how text is generated considering the spatio-temporal context at different levels of granularity. In this work, we present a neural language model architecture that allows us to represent time and space as context for text generation at different granularities. We define the task of modeling text, timestamps, and geo-coordinates as a spatio-temporal conditioned language model task. This task definition allows us to employ the same evaluation methodology used in language modeling, which is a traditional natural language processing task that considers the sequential structure of texts. We conduct experiments over two datasets collected from location-based social networks, Twitter and Foursquare. Our experimental results show that each dataset has particular patterns for language generation under spatio-temporal conditions at different granularities. In addition, we present qualitative analyses to show how the proposed model can be used to characterize urban places.
Analysis of Mitochondrial Function, Structure, and Intracellular Organization In Situ in Cardiomyocytes and Skeletal Muscles
Authors: Kuznetsov Andrey V. , Javadov Sabzali , Margreiter Raimund , Hagenbuchner Judith , Ausserlechner Michael J.
Published: February 2022

Analysis of the function, structure, and intracellular organization of mitochondria is important for elucidating energy metabolism and intracellular energy transfer. In addition, basic and clinically oriented studies that investigate organ/tissue/cell dysfunction in various human diseases, including myopathies, cardiac/brain ischemia-reperfusion injuries, neurodegenerative diseases, cancer, and aging, require precise estimation of mitochondrial function. It should be noted that the main metabolic and functional characteristics of mitochondria obtained in situ (in permeabilized cells and tissue samples) and in vitro (in isolated organelles) are quite different, thereby compromising interpretations of experimental and clinical data. These differences are explained by the existence of the mitochondrial network, which possesses multiple interactions between the cytoplasm and other subcellular organelles. Metabolic and functional crosstalk between mitochondria and extra-mitochondrial cellular environments plays a crucial role in the regulation of mitochondrial metabolism and physiology. Therefore, it is important to analyze mitochondria in vivo or in situ without their isolation from the natural cellular environment. This review summarizes previous studies and discusses existing approaches and methods for the analysis of mitochondrial function, structure, and intracellular organization in situ.
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy
Authors: Morroni Jacopo , Schirone Leonardo , Valenti Valentina , Zwergel Clemens , Riera Carles Sánchez , Valente Sergio , Vecchio Daniele , Schiavon Sonia , Ragno Rino , Mai Antonello , Sciarretta Sebastiano , Lozanoska-Ochser Biliana , Bouchè Marina
Published: February 2022

Chronic cardiac muscle inflammation and subsequent fibrotic tissue deposition are key features in Duchenne Muscular Dystrophy (DMD). The treatment of choice for delaying DMD progression both in skeletal and cardiac muscle are corticosteroids, supporting the notion that chronic inflammation in the heart plays a pivotal role in fibrosis deposition and subsequent cardiac dysfunction. Nevertheless, considering the adverse effects associated with long-term corticosteroid treatments, there is a need for novel anti-inflammatory therapies. In this study, we used our recently described exercised mdx (ex mdx) mouse model characterised by accelerated heart pathology, and the specific PKCθ inhibitor Compound 20 (C20), to show that inhibition of this kinase leads to a significant reduction in the number of immune cells infiltrating the heart, as well as necrosis and fibrosis. Functionally, C20 treatment also prevented the reduction in left ventricle fractional shortening, which was typically observed in the vehicle-treated ex mdx mice. Based on these findings, we propose that PKCθ pharmacological inhibition could be an attractive therapeutic approach to treating dystrophic cardiomyopathy