bluuebunny/crossref_metadata_2025 huggingface dataset:
Inovasi Submersible Pump sebagai Water Sampler untuk Penunjang Praktikum di Manajemen Sumber Daya Perairan
Authors: Boy Syafri , Putra Andi
Published: September 2023

Penelitian ini bertujuan untuk membuat inovasi alat pengambil sampel air berdasarkan kedalaman yang berbeda dengan menggunakan pompa submersible pump. Submersible pump yang digunakan adalah Diesel Pump Operation Instruction DC 24V kapasitas 12 L/menit, cara kerja submersible pump yaitu, mengisap air di dasar perairan dan mendorong ke atas, sehingga hasilnya bisa ditampung. Pompa dipasang dalam pipa PVC 11/4inc kemudian dialirkan sumber energi baterai/accu. Data hasil pengamatan (waktu dan suhu) dianalsisis secara deskriptif. Hasil penelitian menunjukkan bahwa terdapat kesetaraan antara volume panjang pipa 5 m yang telah terbenam dalam perairan dengan air yang dibuang pertama pada pipa 5 m yaitu 6,32 L dibutuhkan waktu 31,63 s. Perbedaan suhu air pada saat masing-masing kedalaman juga berbeda dimana pada kedalaman 1 m suhu air adalah 30 0C sedangkan kedalaman 5 m suhu air adalah 29 0C.  Inovasi ini bisa membantu kelancaran praktikum dan penelitian terutama dalam hal pengambilan air sampel berdasarkan kedalaman yang diinginkan tanpa menggunakan van dorn untuk mahasiswa dan dosen.
Pemanfaatan Limbah Botol Kaca Bekas sebagai Reaktor Sederhana pada Pembuatan Biogas Skala Laboratorium
Authors: Widyasari Yuli Erna
Published: September 2023

Biogas adalah salah satu jenis energi terbarukan yang menarik untuk dikembangkan. Uji potensi pembentukan gas metana (CH4) perlu dilakukan karena metana merupakan gas paling banyak persentasenya pada biogas. Uji potensi gas metana dapat dilakukan dengan menggunakan metode Biochemical Methane Potential (BMP) test. Reaktor dalam uji BMP harus memiliki volume yang disesuaikan dengan homogenitas substrat. Alternatif bahan yang dapat digunakan untuk reaktor salah satunya adalah botol kaca bekas. Botol kaca mempunyai ketahanan yang cukup tinggi, tidak mudah terkontaminasi. Tujuan percobaan ini adalah untuk mengetahui apakah botol kaca bekas dapat digunakan sebagai reaktor sederhana untuk uji BMP pada penelitian biogas skala laboratorium. Pembuatan reaktor sederhana pada percobaan ini menggunakan botol dengan volume 140 ml. Alat dan bahan yang dibutuhkan antara lain tutup botol alumunium, 3-way stopcock, glue gun, lem tembak (glue stick) dan plastisin. Setelah selesai dirangkai, reaktor sederhana tersebut siap digunakan untuk pengujian BMP. Hasil percobaan menggunakan limbah kulit jagung menunjukkan bahwa rerata volume biogas kumulatif yang dihasilkan untuk sampel inokulum, α-selulosa, dan limbah kulit jagung adalah 44,44 ml; 164,70 ml; dan 163,48 ml.Rata-rata potensi metana spesifik untuk sampel inokulum, α-selulosa, dan limbah kulit jagung adalah 0,026 m3/kg VS; 0,501 m3/kg VS; dan 0,462 m3/kg VS.Berdasarkan percobaan tersebut maka reaktor sederhana dari botol kaca bekas dapat digunakan untuk uji BMP pada penelitian biogas skala laboratorum.
Does Heuristic Bias Matter for Long And Short-Term Investment Decision-Making During The COVID-19 Pandemic?
Authors: Sudirman Wahyu Febri Ramadhan , Alif Muhammad Ikhsan , Pratiwi Anggun
Published: September 2023

Introduction/Main Objectives: This study examines the effect of heuristic behavior on investment decision-making in the long- and short-term during the COVID-19 pandemic in the Indonesian capital market. Background Problems: Traditional finance cannot fully explain how investors behave in the capital market. Investors will tend to use heuristics when making investment decisions because humans have cognitive limitations, as explained in the bounded rationality theory. Especially during the COVID-19 pandemic, investors have shown their irrationality due to the high uncertainty and panic caused by the COVID-19 pandemic. This phenomenon can only be explained by behavioral finance. Novelty: This study examines the effect of bias on the invest­ment decision-making of investors who make long-term and short-term investments. Previous studies only tested the impact of bias directly, without differentiating the length of time of the investment. Research Methods: This study used partial least squares structural equation modelling (PLS-SEM) with WarpPLS tool. Testing the moderating effect was undertaken using multi-group analysis (MGA). Finding/ Results: The results of this study indicate that anchoring and availability bias have a positive effect on investment decision-making, while representativeness bias has no significant impact. Investment time moderates the effect of representativeness bias on irrational investment decision-making, while anchoring and availability bias are not supported. Conclusion: Anchoring and availability heuristics will increase irrational investment decisions, while the effect of representativeness heuristics on irrational investment decisions will decrease when investors make long-term investments.
Peningkatan Akurasi Adaptive Monte Carlo Localization Menggunakan Convolutional Neural Network
Authors: Riza Agung Firmansyah  , Tri Arief Sardjono  , Ronny Mardiyanto
Published: September 2023

Makalah ini menjelaskan peningkatan akurasi sistem lokalisasi adaptive Monte Carlo localization (AMCL) pada robot menggunakan convolutional neural network (CNN). Sistem lokalisasi pada sebuah robot merupakan proses pengenalan posisi suatu robot dalam lingkungan kerjanya. Sistem ini penting karena memungkinkan robot untuk melakukan navigasi dan pemetaan (mapping) secara efisien dan akurat. Tanpa lokalisasi yang tepat, robot tidak dapat beroperasi dengan efektif dan dapat mengalami masalah, seperti kehilangan arah atau menabrak objek. AMCL merupakan sistem lokalisasi yang populer dan banyak digunakan dalam robot. Metode ini menggunakan perubahan posisi robot dan perubahan pembacaan sensor light detection and ranging (LiDAR) sebagai masukannya. Pembacaan perubahan posisi robot rentan terhadap kesalahan akibat slip maupun deformasi roda. Ketidaktepatan pembacaan perubahan posisi robot menyebabkan prediksi posisi robot oleh AMCL menjadi kurang tepat, sehingga diperlukan sebuah perbaikan. Pada makalah ini, kebaruan yang diangkat adalah memberikan nilai kompensasi dari hasil AMCL, sehingga error-nya menjadi kecil. Nilai kompensasi tersebut didapatkan dari hasil pelatihan CNN, sehingga metode yang diusulkan tersebut dapat disebut AMCL+CNN. Masukan yang diberikan pada CNN adalah perubahan nilai odometry roda dan perubahan pembacaan jarak oleh sensor LiDAR. Keluaran CNN tersebut dibandingkan dengan data target berupa posisi aktual robot dari hasil pengamatan. Pelatihan jaringan dilakukan sebanyak 200 epoch untuk mendapatkan validation loss terkecil. Pengujian dilakukan pada sebuah robot yang telah dilengkapi dengan robot operating system (ROS). Dataset pelatihan dan pengujian yang diujikan berasal dari data rosbag saat robot berjalan di area pengujian. Hasil yang didapatkan algoritma AMCL+CNN memiliki error yang lebih kecil dibandingkan AMCL dan Monte Carlo localization (MCL) reguler pada skenario lurus dan belok. Hasil yang diperoleh juga lebih baik pada metrik error posisi saat dibandingkan dengan beberapa metode pembanding lain.
Efficacy and Safety of Upacicalcet in Hemodialysis Patients with Secondary Hyperparathyroidism
Authors: Shigematsu Takashi , Koiwa Fumihiko , Isaka Yoshitaka , Fukagawa Masafumi , Hagita Keiko , Watanabe Yukihisa S. , Honda Daisuke , Akizawa Tadao
Published: September 2023

Background

Secondary hyperparathyroidism is a major complication of patients undergoing hemodialysis (HD). Upacicalcet, a new injectable calcimimetic, acts on calcium-sensing receptors to suppress parathyroid hormone (PTH) secretion. We examined the efficacy and safety of upacicalcet in patients with secondary hyperparathyroidism receiving HD.

Methods

In this phase 3, double-blind, placebo-controlled study, we randomized Japanese patients undergoing HD with serum intact PTH (iPTH) concentrations >240 pg/ml and corrected calcium concentrations ≥8.4 mg/dl. Either upacicalcet or placebo was administered after each HD session for 24 weeks. The primary outcome was the percentage of participants achieving the target mean serum iPTH concentration (60–240 pg/ml) at weeks 22–24.

Results

A total of 103 participants received upacicalcet, and 50 participants received the placebo. The percentage of participants achieving mean serum iPTH concentrations of 60–240 pg/ml during the evaluation period was 67% (69/103) in the upacicalcet group and 8% (4/50) in the placebo group. The difference between the two groups was 59% (95% confidence interval, 48% to 71%). Upacicalcet also decreased serum fibroblast growth factor-23, bone-specific alkaline phosphatase, total type 1 procollagen-N-propeptide, and tartrate-resistant acid phosphatase-5b concentrations. Adverse events were reported in 85% (88/103) and 72% (36/50) participants in the upacicalcet and placebo groups, respectively. The incidence of upper gastrointestinal adverse events, such as nausea and vomiting, was similar between the two groups. Serum corrected calcium concentrations <7.5 mg/dl were observed in 2% of participants in the upacicalcet group and no participants in the placebo group.

Conclusions

Upacicalcet, a novel injectable calcimimetic, is effective and safe for secondary hyperparathyroidism patients receiving HD.

Clinical Trial Registry Name and Registration Number

Phase 3 Study of SK-1403, NCT03801980.
OPTIMIZATION OF PROCESS PARAMETERS FOR IMPROVED PRODUCTION OF ANTIMICROBIAL METABOLITES FROM NOCARDIOPSIS FLAVESCENS VJMS-18 ISOLATED FROM SOUTH-COASTAL REGIONS OF ANDHRA PRADESH, INDIA
Authors: MOGILI MARY SWAPNA , MUVVA VIJAYALAKSHMI
Published: September 2023

Objective: The objective of the present study is to optimize the cultural parameters for Nocardiopsis flavescens VJMS-18 strain isolated from marine sediment samples of the south-coast of Andhra Pradesh, India.
Methods: The strain N. flavescensVJMS-18 was identified based on morphological, physiological, biochemical and molecular approaches. The effect of environmental parameters such as incubation period, pH, temperature and salt concentration and the effect of various nutrients such as carbon and nitrogen sources and minerals on the bioactive metabolite production by N. flavescens VJMS-18 was evaluated by employing agar well diffusion assay.
Results: The nutritional requirements and cultural conditions to enhance the yield of secondary metabolites are optimized under shake flask conditions. ISP-2 medium supplemented with sodium chloride at 3% maintained at pH 7.0 supported the maximum yield of secondary metabolites by the strain when incubated at 35°C for 8 days. The strain exhibited a broad spectrum of antagonistic activity against Gram-positive (Staphylococcus aureus and Bacillus megaterium) and Gram-negative bacteria (Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa) as well as fungus (Candida albicans).
Conclusion: It was found that the antimicrobial metabolite production by the strain was positively influenced by carbohydrates, nitrogen sources and minerals.
COMPARISON OF TRADITIONAL- AND CASE-BASED METHOD FOR LEARNING PHYSIOLOGY AMONG 1ST YEAR MBBS STUDENTS
Authors: PRAMILA T  , RAMAKRISHNA BANDARU  , PRATHIBHA T  , SURENDRA BV
Published: September 2023

Objective: The medical science of physiology is both basic and applied. Traditional physiology instruction is teacher-centered, with little involvement from the students. A self-directed learning strategy focused on training through the use of personal narratives is known as case-based learning (CBL). The present study was conducted to assess the effectiveness of CBL method in teaching physiology among 1st year MBBS students.
Methods: This study was conducted among 1st year MBBS students of 2022–2023 batch. The study design included a pre-test, a CBL discussion on a specific topic, and a post-test following the CBL session. MS Excel and SPSS version 23 were used to gather, tabulate, and statistically analyze the data. Results from the pre-and post-tests were compared using the student’s “t” test, and p<0.05 was regarded as statistically significant. The 12 questions that made up the feedback survey were all expressed as percentages.
Results: When pre-and post-test results were compared, the post-test score after the CBL session was significantly better than the pre-test score of the session. The majority of students supported CBL activities. In student feedback, more than 95% of the students thought CBL classes helped interaction among them. More than 94% of the students thought CBL classes helped in clearing doubts, helped in increasing interest. More than 91% of the students thought CBL classes improved conceptual thinking.
Conclusion: Through active learning, CBL can be utilized as an addition to lectures to augment standard teaching/learning approaches. It encourages the drive to learn and the development of clinical reasoning
MATERNAL HYPOTHYROIDISM AND ITS EFFECTS ON NEONATAL THYROID FUNCTION: A RETROSPECTIVE STUDY
Authors: VIJAYALAKSHMI CHANDRASEKHAR  , KOMAL SAHITHI BARLA  , SUCHITRA PUSAPATI  , VISWA KALYAN KOLLI  , VENKATA MANASA RONGALA
Published: September 2023

Objective: The objective of the study is to correlate maternal factors (age, parity, type of delivery, thyroid-stimulating hormone [TSH], and thyroxine [T4] values) and the newborn factors (gestational age, birth weight, and gender) with the TSH and T4 values of the newborn.
Methods: A retrospective observational study was conducted on 90 hypothyroid mothers who were delivered at our Institute between January 2022 and March 2023. The 90 neonates born to these hypothyroid mothers underwent newborn screening tests for thyroid functions (tri-iodothyronine, T4, TSH) after 72 h of birth. These values were statistically analyzed with respect to maternal and fetal parameters.
Results: 7 of the 90 neonates (7.77%) had elevated TSH values, i.e., >10 mIU/L. T4 values were abnormal in 31 neonates (34.4%), i.e., <11 ug/dL or >21.5 ug/dL but had normal TSH values. There was only one case where T4 levels were low and TSH level elevated. The correlation of TSH values with maternal and fetal parameters such as age of mother, parity, gestational age, baby weight, type of delivery, and the gender of the baby was not significant as p-values were all >0.05. There is a weak negative correlation (r=−0.044) between maternal TSH and neonatal TSH values which was statistically not significant. However, the maternal TSH and baby weight values are having positive correlation (r=0.113).
Conclusion: Our study showed no significant correlation between maternal hypothyroidism and newborn TSH and T4 values which may be due to early antennal recognition and supplementation with levothyroxine.
Integration of English ‘teaching-learning-assessing’ in Chinese High Schools: A Literature Review
Authors: Ting Ye
Published: September 2023

Classroom assessment has always been the focus of research on foreign language teaching, and "integration of teaching and assessment" has become a heated topic in international second language teaching field, but this topic has not yet attracted the attention of some scholars. In result, this paper retrieves the papers published domestic and abroad between 2017 and 2023 focusing on the "integration of teaching and evaluation" in English subject as data sources and analyzes the research contents. The results show that the research type of "integration of teaching-learning-assessing" is mainly theoretical research, but the number of empirical research is quite small. Besides, the theoretical research also shows an upward trend. The research objects are mainly secondary school English teachers and students. The research content focuses on the following four aspects: the definition of "integration of teaching-learning-assessing"; the implementation path of "integration of teaching-learning-assessing" in the classroom; the application of "integration of teaching-learning-assessing" in specific subjects and the investigation of "integration of teaching-learning-assessing" in the classroom. The data collection methods were mainly questionnaires, interviews and classroom observations. In the end of this paper, the future research and the development trend of "integration of teaching-learning-assessing" are pointed out.
Ballón Aguirre, José. El legado multicultural de Martí y la voz peruana de Emerson. Madrid: Editorial Pliegos, 2022
Authors: Martínez Carrizales Leonardo
Published: September 2023

Reseña del libro: Ballón Aguirre, José. El legado multicultural de Martí y la voz peruana de Emerson. Madrid: Editorial Pliegos, 2022.
Hybrid Quantum-Enhanced Machine Learning for Supply Chain Optimization
Authors: M Vignesh , S Senthil Prabhu , K Prabhu , Subramanian R M
Published: September 2023

Abstract: Modern supply chains face intricate challenges demanding sophisticated optimization strategies.This research presents a pioneering approach, combining quantum computing and machine learning, to revolutionize supply chain optimization. A hybrid framework harmonizes the power of quantum computing, including quantum annealers and gate-based quantum devices, with classical machine learning techniques. This synthesis aims to surmount the limitations of conventional optimization methods. Through rigorous experimentation on real-world supply chain scenarios, our approach demonstrates substantial efficiency gains and enhanced solution quality in comparison to classical methods. The implications are far- reaching, promising substantial cost reductions, streamlined resource allocation, and sustainability improvements for industries relying on supply chain management. Our study contributes to the burgeoning field of quantum machine learning and offers immediate value to supply chain professionals grappling with complexity. As supply chains evolve, our research sets the stage for innovative solutions in the quest for optimization.
Environmental Cost Accounting Practices in Waste Management
Authors: Mustika Ira , Oktavendi Tri Wahyu , Affan Muhammad Wildan
Published: September 2023

Purpose: This study aims to determine and analyze how TPST 3R Mulyoagung Bersatu discloses waste management and applies environmental cost accounting in the identification, recognition, measurement, presentation and disclosure of environmental costs in the financial statements, and classifies environmental costs into environmental prevention costs, environmental detection costs, internal environmental failure costs and external environmental failure costs. Methodology/approach: This research was conducted at the Integrated Waste Management Site (TPST) 3R Mulyoagung Bersatu, Dau District, Malang Regency. This research is a qualitative research. In this study using primary and secondary data. Primary data was obtained through interviews, documentation and observation in the field. While secondary data is obtained from data or documents of TPST 3R Mulyoagung Bersatu. Findings: The results of this study are that TPST 3R Mulyoagung Bersatu recognizes costs using the cash basic method and environmental costs are recognized as a component of production costs, namely general operational costs and fuel, employee costs and maintenance costs. Environmental costs at TPST 3R Mulyoagung Bersatu are environmental prevention costs; salary costs and costs of cleaning equipment and cleaning materials, environmental detection costs; none, environmental internal failure costs; vehicle and machinery maintenance costs, building and infrastructure maintenance costs, social costs, external failure costs; none. Practical implications: the results of this study have implications for the development of environmental cost accounting practices in waste management. Originality/value: the research results show that the environmental costs accounting is very relevant and important to waste management because it can evaluate and reduce the environmental impact of the waste management process
The Role of Local Government in Creating Business Sustainability: Case Study on Keris MSMES in Aeng Tong-Tong Village
Authors: Noerhalifah Rohatina , Hafidhah Hafidhah , Herli Mohammad
Published: September 2023

Purpose: This study aims to determine the role of the Sumenep Regency government in creating business sustainability for Keris MSMEs in Aeng Tong-tong Village. Methodology/approach: Research conducted using qualitative research types. The types of data in this study are subject and documentary data. The data sources used are primary data and secondary data. Data collection techniques carried out by researchers use observation, documentation and interviews. Findings: The results of this study show that the role of the government in creating Business Sustainability in MSMEs is in the form of promotions, exhibitions, cost assistance for jamming, and coaching through tourism awareness groups (pokdarwis). Apart from that, the people of Aeng Tong-Tong village took the initiative by participating in events independently, namely participating in provincial and national Tourism Village competitions. Practical implications: However, there are several forms of government policies in supporting social policies such as participating in tourism village competitions, assistance with jamasan fees, and pelar agung. For now, the government's efforts in supporting the creation of environmental sustainability have not been felt by keris craftsmen. Because the focus of the local government for now only focuses on how to advance business development, namely by improving the economic performance of the kris craftsmen themselves. Originality/value: This research is considered very interesting to be carried out in Sumenep Regency considering the lack of research discussing Business Sustainability in the Sumenep area, as well as the number of MSMEs in Sumenep Regency will certainly feel the impact on the implementation of Business Sustainability.
Management of Parshnishool (Heel Pain) Due to Vatakantaka (Calcaneal Spur) With Agnikarma (Therapeutic Burn). – A Case Report.
Authors: Jadhav Divya , Deshpande Mayuri Amol , Deshpande Amol Madhav , Urkude Minakshi
Published: September 2023

Pain is the commonest symptom due to which patients come to the Physician. Every patient wants instant relief from such type ofunwanted feelings. Conventional therapies have many painkillers that instantly give the desired effect with a byproduct of many side effects.Parshnishool (Heel pain) occurring due to Vatakantaka (calcaneal spur) is a common type of pain nowadays. It hampers day-to-day life choresaffecting the physical as well as mental status of an individual. Ayurveda has solutions for all types of diseases occurring in every Era. Thecalcaneum has tiny osteophyte projections known as calcaneal spurs. It is not an acute illness with abrupt onset. It takes place as a result ofprogressive changes in that area. Calcaneal spurs are often seen in two regions: the inferior and posterior ones. The lower one is placed onthe calcaneum's inferior side and frequently reacts to plantar fasciitis over time. Calcaneal spur and its symptoms can be easily treated withAgnikarma means therapeutic heat application. Vata is the causative factor in all types of pain. There are a total of 80 diseases that occur due tothe vitiation of Vata. Vata and Agni have exactly opposite properties. In this case, we use Loha shalaka (Iron lancet) for therapeutic burns. Lohashalaka gives more relief from pain than any other shalakas. The patient got complete relief after three sittings. He was advised with someinternal medication as supplements. Agnikarma is the easy, less time-consuming, and financially affordable treatment in Pashnishool occurring inVatakantaka with no side effects.
In Vitro and in Silico Analysis of Phytochemicals from Asteraceae Plant Species Against Wound-Infecting Pathogens
Authors: Shanmugam K.S. , Ramkumar L. , Jagadeesan R.
Published: September 2023

The idea of polyherbal combinations has a strong foundation in modern medicine and has had amazing success, givingpatients new hope. Polyherbal mixtures have managed various conditions, from cancer to autoimmune disorders. Given that it hasalready been shown to be secure and efficient, this therapeutic approach is gaining popularity. In alternative, complementarytherapies, polyherbal formulations blend many herbs to provide an additive effect. Physicians are accepting this strategy, which hasbeen used for generations. Numerous research papers in the pharmaceutical field demonstrate the efficacy of combining plants andthe present study aimed to evaluate antibacterial phytochemicals from a polyherbal extract. Phytoconstituents extracted with ethanoland ethyl acetate by conventional soxhlet method and chemical constituents were analyzed by qualitative and GC-MS. Antibacterialactivity of extracts tested by disc diffusion method against wound infecting pathogens. MIC was done by Alamar blue assay. Inhibitionof ESBL enzyme predicted by in silico docking using Autodock. Extraction with ethanol shows less significant positive results thanethylacetate in qualitative and antibacterial studies. GC-MS analysis showed the presence of 35 bioactive compounds from ethylacetate and 45 compounds from ethanol. Cyclononasiloxane, Octodecane, hexadecanoic acid, and Benzenedicarboxylic werecommonly found in both extracts. The ethylacetate PHE exhibited strong antibacterial activity and was more effective than thestandard. From GCMS, three compounds were predicted to have good ADME characteristics with high gastrointestinal absorptionand metabolic activity. Compound 6-(3-fluorobenzylamino) purine has been selected and investigated by in silico method, showingthat it has a greater binding affinity with ESBL, ompC, and murA after being docked. The ethyl acetate extract demonstrated goodaction against certain pathogenic bacteria in the current experiment, while the ethanol extract exhibited no activity. Our findingsconclude that the polyherbal extracts have broad-spectrum activity against bacteria and depend on the solvent used.
ANALISIS DAN REDESAIN RPS BERBASIS RISET UNTUK MENINGKATKAN KEMAMPUAN 6C MAHASISWA PADA MATA KULIAH BAHASA INDONESIA
Authors: Damayanti Welsi , Fuadin Ahmad , Wijaya Abdul Rozak Rama
Published: September 2023

Penelitian ini bertujuan untuk melakukan analisis dan redesain RPS (Rencana Pembelajaran Semester) berbasis riset dalam rangka meningkatkan kemampuan 6C (Communication, Collaboration, Critical Thinking, Creativity, Compassion, and Computational Thinking) mahasiswa pada mata kuliah Bahasa Indonesia. Penelitian ini dilakukan dengan menggunakan pendekatan kualitatif dan metode deskriptif. Data dikumpulkan melalui analisis dokumen RPS yang sudah ada dan melalui wawancara dengan dosen pengampu Mata Kuliah Bahasa Indonesia. Hasil analisis dokumen menunjukkan bahwa RPS yang ada belum secara optimal memperhatikan pengembangan kemampuan 6C pada mahasiswa. Beberapa komponen yang dapat meningkatkan pengembangan kemampuan 6C, seperti penggunaan strategi pembelajaran yang aktif, kolaboratif, dan reflektif, serta integrasi teknologi dalam pembelajaran, masih perlu diperkuat dalam RPS yang ada. Berdasarkan temuan analisis dan tinjauan literatur, dilakukan redesain RPS dengan memasukkan komponen-komponen yang relevan untuk meningkatkan pengembangan kemampuan 6C pada Mata Kuliah Bahasa Indonesia. Redesain RPS ini mencakup penggunaan strategi pembelajaran yang mendorong mahasiswa untuk berkomunikasi aktif, berkolaborasi dengan teman sejawat, berpikir kritis dalam menganalisis teks, mengembangkan kreativitas dalam mengekspresikan ide, menumbuhkan empati terhadap keberagaman budaya, dan mengasah kemampuan berpikir komputasional dalam penggunaan teknologi pendukung. Redesain RPS yang telah disusun kemudian diimplementasikan dalam lingkungan pembelajaran bahasa Indonesia. Mahasiswa yang terlibat dalam implementasi RPS yang diredesain memberikan respons positif terhadap pendekatan pembelajaran yang lebih aktif, kolaboratif, dan melibatkan teknologi. Hasil penelitian ini menunjukkan bahwa analisis dan redesain RPS berbasis riset dapat efektif dalam meningkatkan pengembangan kemampuan 6C mahasiswa pada Mata Kuliah Bahasa Indonesia. Implikasi dari penelitian ini adalah pentingnya pengembangan RPS yang mendukung pengembangan kemampuan 6C untuk mempersiapkan mahasiswa menghadapi tuntutan dunia kerja yang semakin kompleks dan dinamis.
The implications of conversion for the converted public joint stock companies
Authors: Madi Ramzi , Masn Muna
Published: September 2023

The phenomenon of company conversion is on the rise, both in the United Arab Emirates (UAE) and Jordan. This study aims to investigate the concept of conversion and examine the implications it has on the converted company. We explore the continuity of the converted company’s legal personality and discuss its significant outcomes, whether affecting the converted company itself or others involved. Specifically, we analyze the impact of the conversion on the company’s pre-conversion obligations, liabilities, and contracts. Furthermore, we examine the regulations governing the new form adopted by the converted company, both in its internal operations and relationships with partners, as well as its external interactions with others. Additionally, we provide an explanation for the capital increase when a company converts into a public joint stock company. The problem addressed in this paper is to determine the consequences of conversion for the converted company. To investigate this topic, we employ analytical and comparative methodologies. We conclude that the conversion of a company does not lead to the termination of the transferred company’s legal personality and the creation of a new legal entity.
Root development differences between cleft-adjacent teeth on the cleft side in comparison to their analogs on the noncleft side in patients with nonsyndromic cleft lip and palate who received secondary alveolar bone grafting
Authors: Vandersluis-Solomon Yona R. , Suri Sunjay , Fisher David M. , Stevens Kyle , Tompson Bryan D. , Lou Wendy
Published: September 2023

Objective

To assess differences in root development between the cleft side (CS) and noncleft side (NCS) for permanent maxillary central incisor and canine longitudinally in patients with nonsyndromic complete unilateral cleft lip and palate (cUCLP) who received secondary alveolar bone grafting (SABG) and to evaluate the effects of SABG on the acceleration of root development of these teeth.

Materials and Methods

Permanent maxillary central incisors and canines of 44 subjects with nonsyndromic cUCLP who had all their cleft-related surgeries performed by the same surgeon were analyzed retrospectively from chart notes and radiographs. Panoramic and periapical radiographs at time point 1 (T1) (age, 7.55 years), at SABG (time point 2 [T2], 10.13 years), and a minimum of 2 years after SABG were studied. Root development rating scores on the NCS and CS were compared using paired t-tests and analyses of proportions.

Results

Mean root development score differences (NCS − CS) for canines and central incisors were greatest at T2 but diminished at time point 3 (T3). A larger proportion of teeth on the CS trailed the teeth on the NCS by at least 1 point at T2 than at T1 or T3, with the smallest proportion being observed at T3. The change in root development scores from T1 to T2 and from T2 to T3 showed relative CS acceleration from T2 to T3, indicating a catch-up of root development of cleft-adjacent teeth after SABG.

Conclusions

Root development of cleft-adjacent central incisors and canines is slow in comparison with their noncleft analogs. Root development of these teeth accelerates following SABG.
Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation
Authors: Luk Cynthia T. , Chan Carmen K. , Chiu Felix , Shi Sally Yu , Misra Paraish S. , Li Yu Zhe , Pollock-Tahiri Evan , Schroer Stephanie A. , Desai Harsh R. , Sivasubramaniyam Tharini , Cai Erica P. , Krishnamurthy Mansa , Han Daniel J. , Chowdhury Apu , Aslam Rukhsana , Yuen Darren A. , Hakem Anne , Hakem Razqallah , Woo Minna
Published: September 2023

Caspases are cysteine-aspartic proteases that were initially discovered to play a role in apoptosis. However, caspase 8, in particular, also has additional nonapoptotic roles, such as in inflammation. Adipocyte cell death and inflammation are hypothesized to be initiating pathogenic factors in type 2 diabetes. Here, we examined the pleiotropic role of caspase 8 in adipocytes and obesity-associated insulin resistance. Caspase 8 expression was increased in adipocytes from mice and humans with obesity and insulin resistance. Treatment of 3T3-L1 adipocytes with caspase 8 inhibitor Z-IETD-FMK decreased both death receptor–mediated signaling and targets of nuclear factor κ-light-chain-enhancer of activated B (NF-κB) signaling. We generated novel adipose tissue and adipocyte-specific caspase 8 knockout mice (aP2Casp8−/− and adipoqCasp8−/−). Both males and females had improved glucose tolerance in the setting of high-fat diet (HFD) feeding. Knockout mice also gained less weight on HFD, with decreased adiposity, adipocyte size, and hepatic steatosis. These mice had decreased adipose tissue inflammation and decreased activation of canonical and noncanonical NF-κB signaling. Furthermore, they demonstrated increased energy expenditure, core body temperature, and UCP1 expression. Adipocyte-specific activation of Ikbkb or housing mice at thermoneutrality attenuated improvements in glucose tolerance. These data demonstrate an important role for caspase 8 in mediating adipocyte cell death and inflammation to regulate glucose and energy homeostasis.

Article Highlights

Caspase 8 is increased in adipocytes from mice and humans with obesity and insulin resistance. Knockdown of caspase 8 in adipocytes protects mice from glucose intolerance and weight gain on a high-fat diet. Knockdown of caspase 8 decreases Fas signaling, as well as canonical and noncanonical nuclear factor κ-light-chain-enhancer of activated B (NF-κB) signaling in adipose tissue. Improved glucose tolerance occurs via reduced activation of NF-κB signaling and via induction of UCP1 in adipocytes.
Sex Differences in Age of Diagnosis, HLA Genotype, and Autoantibody Profile in Children With Type 1 Diabetes
Authors: Tojjar Jasaman , Cervin Matti , Hedlund Emma , Brahimi Qefsere , Forsander Gun , Elding Larsson Helena , Ludvigsson Johnny , Samuelsson Ulf , Marcus Claude , Persson Martina , Carlsson Annelie
Published: September 2023

OBJECTIVE

To examine sex differences in children with newly diagnosed type 1 diabetes (T1D) with respect to age at diagnosis, presence of autoantibodies (GAD antibody [GADA], insulinoma-associated protein 2 [IA-2A], insulin autoantibody [IAA], and zinc transporter 8 autoantibody), and HLA risk.

RESEARCH DESIGN AND METHODS

A population-based nationwide sample of 3,645 Swedish children at T1D diagnosis was used.

RESULTS

Girls were younger at T1D diagnosis (9.53 vs. 10.23 years; P < 0.001), more likely to be autoantibody-positive (94.7% vs. 92.0%; P = 0.002), more often positive for multiple autoantibodies (P < 0.001), more likely to be positive for GADA (64.9% vs. 49.0%; P < 0.001), and less likely to be positive for IAA (32.3% vs. 33.8%; P = 0.016). Small sex differences in HLA risk were found in children <9 years of age.

CONCLUSIONS

The disease mechanisms leading to T1D may influence the immune system differently in girls and boys.
A faecal metabolite signature of impaired fasting glucose: results from two independent population-based cohorts
Authors: Nogal Ana , Tettamanzi Francesca , Dong Qiuling , Louca Panayiotis , Visconti Alessia , Christiansen Colette , Breuninger Taylor , Linseisen Jakob , Grallert Harald , Wawro Nina , Asnicar Francesco , Wong Kari , Baleanu Andrei-Florin , A. Michelotti Gregory , Segata Nicola , Falchi Mario , Peters Annette , W. Franks Paul , Bagnardi Vincenzo , D Spector Tim , T Bell Jordana , Gieger Christian , M Valdes Ana , Menni Cristina
Published: September 2023

Prediabetes is a metabolic condition associated with gut microbiome composition, though mechanisms remain elusive. We searched for faecal metabolites, a readout of gut microbiome function, associated with impaired fasting glucose (IFG) in 142 individuals with IFG and 1105 healthy individuals from TwinsUK. We used the KORA cohort (318 IFG individuals, 689 healthy individuals) to replicate our findings. We linearly combined 8 IFG-positively associated metabolites (1-methylxantine, nicotinate, glucuronate, uridine, cholesterol, serine, caffeine and protoporphyrin IX) into an IFG-metabolite score, which was significantly associated with higher odds ratios for IFG (TwinsUK: OR[95%CI]=3.9[3.02-5.02], p<0.0001, KORA: OR[95%CI]=1.3[1.16-1.52], p<0.0001) and incident type-2 diabetes (T2D) (TwinsUK: HR[95%CI]=4[1.97-8], p=0.0002). Although these are host-produced metabolites, we found that the gut microbiome is strongly associated with their faecal levels (AUC>70%). Abundances of Faecalibacillus intestinalis, Dorea formicigenerans, Ruminococcus torques and Dorea sp. AF24_7LB were positively associated with IFG, and such associations were partially mediated by 1-methylxanthine and nicotinate (VAF mean(SD)=14.4%(5.1), p<0.05). Our results suggest that gut microbiome is linked to prediabetes not only via the production of microbial metabolites but also by affecting intestinal absorption/excretion of host-produced metabolites and xenobiotics, which are correlated with the risk of IFG. Faecal metabolites enable modelling of another mechanism of gut microbiome effect on prediabetes and T2D onset.
Adaptasi Lintas Budaya Kuesioner STOP-Bang Versi Indonesia
Authors: Manullang Putri Anggilina , Saragih Muhammad Arfiza Putra , Adnan Adlin , Silaen Ester Lantika Ronauli
Published: September 2023

Obstructive Sleep Apnea (OSA) merupakan obstruksi saluran napas atas saat tidur yang mengakibatkan penurunan saturasi oksigen. Di Indonesia, data prevalensi OSA masih sangat minim. Dari beberapa alat penapisan OSA, hanya BQ dan ESS yang memiliki versi Bahasa Indonesia, sementara STOP-Bang belum terdapat versi Bahasa Indonesia. Melakukan penapisan terhadap tanda dan gejala sangat penting dalam proses perencanaan dan evaluasi. Suatu alat ukur harus memenuhi unsur psikometrik dan mampu menyesuaikan dengan karakteristik sosial dan budaya setempat. Untuk menghasilkan alat ukur kuesioner STOP-Bang versi Indonesia dengan metode adaptasi lintas budaya yang reliabel dan tervalidasi. Penelitian ini merupakan penelitian observasional analitik menggunakan metode cross sectional. Setelah kuesioner STOP-Bang diadaptasikan ke Indonesia, kuesioner diberikan kepada 500 orang masyarakat Indonesia, kemudian setelah 14 hari akan dilakukan pengisian ulang terhadap 20 responden. Penelitian dilakukan pada bulan Juli sampai September 2023 di Kota Medan dan Binjai. Pengambilan sampel memakai metode purposive sampling. Dari 500 responden penelitian dan validitas diolah menggunakan Spearman correlation didapatkan (p<0.001 dan r=0.422±0.118) berarti ada korelasi bermakna dan cukup valid. Analisis reliabilitas menggunakan Cronbach’s-alpha (r=0,694) dan nilai Interclass Correlation Coefficient menggunakan Spearman correlation coefficient (r=0,886). Adaptasi lintas budaya kuesioner STOP-Bang versi Indonesia memiliki nilai validitas dan reliabilitas yang baik.
Pengembangan Bigbook Berbasis Mitigasi Bencana Untuk Meningkatkan Kompetensi Guru PAUD di Lombok Tengah
Authors: Tatminingsih Sri , Gani Ramlah AH , Nurdin  , Hulaifi  , Anam Khaerul
Published: September 2023

Kegiatan ini bertujuan untuk meningkatkan kompetensi paedagogis Guru PAUD dalam hal merancang bahan belajar berbasis mitigasi bencana dan melaksanakan pembelajaran dengan big book. Pelakasanaan kegiatan dilakukan dengan modus gabungan, yaitu secara daring (dalam jaringan) dan luring (luar jaringan) sesuai dengan kondisi di lapangan. Mitra kegiatan adalah Ikatan Guru Raudhatul Athfal (IGRA) Kabupaten Lombok Tengan - Nusa Tenggara Barat. Jumlah Peserta sebanyak 12 Guru yang masing-masing mewakili satu Raudhatul Attfal (RA). Pelaksana kegiatan adalah Dosen Universitas Terbuka (UT) dari berbagai Program Studi dan Mahasiswa PGPAUD-UT yang juga berperan sebagai fasilitator. Kegiatan dilaksanakan Bulan Agustus- Oktober 2021. Pelaksanaan mencakup kegiatan Focus Group Disscussion (FGD) sebanyak dua pertemuan dan Pendampingan sebanyak 4 pertemuan. Di antara setiap pertemuan tersebut terdapat kegiatan mandiri yang dilakukan oleh Peserta dengan didampingi Fasilitator. Hasil kegiatan berupa produk Big book yang terdiri dari Format rancangan pengembangan Big book, Big book dan Lembar kerja Anak (LKA). Selain itu hasil kegiatan menunjukkan bahwa Peserta mengalami peningkatan dalam kemampuan merancang dan melaksanakan pembelajaran, khususnya dengan menggunakan Big book.
Pemberdayaan Masyarakat Melalui Pengolahan Limbah Organik Cair Berbasis Bio Slurry Dalam Upaya Mengurangi Tingkat Pengangguran Masyarakat Desa Bongkasa Pertiwi Akibat Pandemi Covid-19
Authors: A.A.Istri Mirah Dharmadewi  , Gede Sidi Artajaya  , I.G.A Gede Wiadnyana  , I Wayan Suanda
Published: September 2023

ABSTRAK

Desa Bongkasa Pertiwi, Abiansemal, Badung merupakan   Desa Bongkasa merupakan desa yang memiliki potensi besar di bidang pertanian dan peternakan. Potensi tersebut diantaranya terdapat limbah bio-slurry atau kotoran ternak yang belum dimanfaatkan secara maksimal dan saluran penampungan limbah belum tertampung dengan baik. Selain itu, potensi di bidang sumber daya manusia Desa Bongkasa dengan kelompok-kelompok yang bergerak di bidang pertanian dan peternakan masih belum maksimal. Masyarakat Desa Bongkasa memiliki minat yang tinggi terhadap kegiatan pemanfaatan limbah ini, akan tetapi minimnya pengetahuan terkait aspek-aspek budidaya menjadi hambatan untuk meningkatkan kualitas hasil produksi Bio-slurry merupakan salah satu limbah yang dapat dimanfaatkan sebagai alternative pengganti gas LPG namun belum semua masyarakat memanfaatkannya dengan maksimal. Pembuatan limbah ternak ini dan cara mengolah yang mudah dan bernilai jual tinggi menjadi salah satu alasan mengembangan limbah bio-slurry ini dari Desa Bongkasa Pertiwi dengan memanfaatkan warga desa terdampak Covid-19. Melalui Kelompok tani Manik Pertiwi,masyarakat Desa Bongkasa pertiwi telah mengembangkan pengolahan limbah Bio-slurry namun terdapat beberapa kendala sehingga pengelolaannya kurang maksimal. Adapun beberapa metode yang dilakukan dalam kegiatan ini yaitu : sosialisasi, pendampingan dan pelatihan pengolahan limbah bi-slurry, pengadaan alat, membantu menentukan desain kemasan produk dan membantu pemasaran melalui website serta media sosial. Hasil yang didapatkan setelah melakukan kegiatan diantaranya yaitu : Kelompok Tani di Desa bongkasa Pertiwi mengalami peningkatan pengetahuan dalam mengolah limbah bio-slurry dengan baik dan memiliki nilai jual yang tinggi sebesar 85%.
PELATIHAN PENGOLAHAN MINYAK GORENG BEKAS (JELANTAH) MENJADI BIODIESEL DENGAN KATALIS ENZIM DI KOTA DENPASAR
Authors: Tika I Nyoman , Kadek Wimardiyanti
Published: September 2023

Kegiatan ini merupakan pelaksanaan salah satu tri dharma perguruan tinggi, yakni pengabdian  masyarakat. Tujuan kegiatan ini  mentransfer teknik  pengolahan limbah minyak goreng (minyak jelantah ) menjadi biodiesel dengan menggunakan katalis enzim. Masyarakat  sasaran adalah salah satu pengolahan minyak jelantah di Kota Denpasar yaitu CV Caritas. yang berlokasi Ubung  Kaja Denpasar, Dalam kegiatan ini melibatkan karyawan sebanyak 10 orang sebagai tenaga yang bekerja  untuk memproduksi biodiesel . Metode pelaksanaan pengabdian masyarakat ini adalah metode PALS (participatory action learning system), yakni model pemberdayaan masyarakat dengan tahapan-tahapan kegiatan, (1) penyadaran, (2) pengkapasitasan dan (3) pendampingan.  Hasil yang diperoleh dari kegiatan  P2M ini adalah  (1) Kegiatan  telah berlangsung dengan baik, dan mitra  telah mendapat  pengalaman langsung dalam teknologi  produksi  pengolahan minyak  jelantah menjadi  biodiesel dengan bantuan enzim dengan kualitas yang baik, Tingkat kepuasan  adalah sebesar 85%, cukup 14 % dan 1%  biasa saja..
DISEMINASI DARTFISH SOFTWARE SEBAGAI APLIKASI SPORTS BIOMECHANICS ANALYSIS
Authors: Doewes Rumi iqbal , Manshuralhudlori  , Pomo Warih Adi  , Satria Yudi Gontara  , Singgih Hendarto  , Agustiyanta  , Abdul Aziz Purnomo Shidiq  , Ahmad Septiandika Adirahma
Published: September 2023

Dartfish software sebagai aplikasi sports biomechanics analysis digunakan untuk menganalisis suatu gerak tubuh dalam aktivitas olahraga. Hal ini bermanfaat dalam pengembangan keterampilan gerak pada suatu cabang olahraga. Minimnya pengetahuan pelatih NPCI terkait Dartfish software dan penerapan ilmu biomekanika dalam latihan. Tujuan pengabdian ini adalah untuk memberikan informasi mengenai Dartfish software dan cara menggunakan Dartfish software untuk menganalisis gerakan olahraga. Pengabdian dilakukan dengan diseminasi dan pendampingan. Mitra pengabdian adalah pelatih NPCI berjumlah 25 orang. Evaluasi dilakukan dengan menguji pengetahuan mitra terkait biomekanika olahraga dan Dartfish software. Instrumen yang digunakan adalah angket pernyataan dengan 20 pernyataan terkait biomekanika olahraga dan Dartfish software. Hasil penelitian menunjukan bahwa sebelum diberikan materi, mitra hanya mampu menjawab benar sebanyak 39.60% sedangkan 60.40% menjawab pertanyaan dengan salah. Setelah diberikan materi, pengetahuan mitra mengalami peningkatan sebesar 36.20% sehingga 75.80% telah menjawab dengan jawaban benar dan hanya 24.20% yang masih menjawab salah. Kesimpulan pengabdian ini adalah pengetahuan mitra pengabdian tentang biomekanika olahraga dan Dartfish software telah mengalami peningkatan.
PENDAMPINGAN BAHASA INGGRIS BERBASIS BUDAYA LOKAL DI DESA WISATA BANGKA KENDA
Authors: Menggo Sebastianus , Jem Yosefina Helenora , Fatmawati  , Robertus Ansi  , Yakobus Sandiawan Asman
Published: September 2023

Bahasa dan budaya memiliki hubungan erat, tidak ada performansi ritus budaya tanpa menggunakan bahasa. Performansi aneka ritus budaya, tidak dapat dipisahkan dari kemampuan berbahasa. Kecakapan berbahasa Inggris berimplikasi pada interpretasi makna atas pertunjukkan ritus budaya. Pengabdian kepada Masyarakat ini bertujuan mendorong peningkatan partisipasi masyarakt desa untuk mampu menarasikan aneka performansi ritus-ritus budaya lokal dalam bahasa Inggris kepada wisatawan dan kesadaran untuk pemertahanan nilai-nilai budaya. Peserta PkM ini berjumlah 30 orang. Pengabdian ini dijalankan di dua tempat, yakni Kapela Kenda dan SDI Kenda selama dua bulan. Ceramah, bermain peran, diskusi kelompok kecil, serta presentasi merupakan pendekatan yang diterapkan untuk mencapai tujuan PkM. Hasilnya mengindikasikan bahwa peserta mampu menjelaskan dalam bahasa Inggris tradisi budaya lokal mereka dan tersedianya teks-teks tertulis untuk sejumlah ritus budaya.
PELATIHAN DAN PENDAMPINGAN KADER POSYANDU DALAM UPAYA PENCEGAHAN HIPERTENSI DALAM KEHAMILAN (HDK) DI WILAYAH KERJA PUSKESMAS SUKASADA I
Authors: Sekarini Ni Nyoman Ayu Desy , Putu Irma Pratiwi  , Anjar Triastuti
Published: September 2023

HDK merupakan  hipertensi yang dapat terjadi pada masa kehamilan. HDK sangat berdampak kepada kesehatan ibu dan jani.  Berbagai faktor resiko dapat menyebabkan HDK salah satunya peran kader. Kader merupakan anggota masyarakat yang paling dekat dengan ibu hamil, sehingga diharapkan daer dapat melaksankan pencegahan terhadap kejadian HDK. Pengabdian kepada masyarakat ini dilakukan pelatihan dan pendampingan kader posyandu dalam melaksanakan pencegahan HDK. Hasil dari pengabdian masyarakat ini yaitu pada tahap pelatihan kader diberikan materi dan diajarkan keterampilan mengukur tekanan darah dengan tensi mater digital. Hasil Prettes dan posttes yang telah dilakukan terdapat rata-rata peningkatan pengetahuan sejumlah 30 poin. Berdasarkan data tersebut juga dapat dilihat bahwa Sebagian besar  9 (60%) peserta memiliki pengetahuan baik. Pada tahap pendampingan seluruh kader telah melaksanakan penyuluhan dan pengukuran tensi pada ibu hamil dalam upaya pencegahan HDK. Diharapkan kader posyandu secara rutin dan berkelanjutan melaksakan penyuluhan terkait HDK dan mengukur tekanan darah pada ibu hamil saat kegiatan posyandu berlangsung