bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimized OCT with Undetected Photons Based on an Integrated Waveguide PDC Source
Authors: Roeder Franz , Pollmann René , Stefszky Michael , Quiring Victor , Ricken Raimund , Eigner Christof , Brecht Benjamin , Silberhorn Christine
Published: September 2024

We present the experimental realization of an optical coherence tomography scheme with undetected photons using a nonlinear waveguide in an SU(1,1)-interferometer. A differential pumping scheme is investigated and incorporated to optimize the measured interferograms.
Full Quantum Approaches to a Dispersive Transmission Line using Josephson Junctions
Authors: Yuan Yongjie , Haider Michael , Aşırım Özüm Emre , Jirauschek Christian
Published: September 2024

We present two promising approaches that provide a full quantum description for the dissipation and thermal fluctuations in a dissipative-dispersive Josephson traveling-wave parametric amplifier, and highlight the advantages of both approaches.
Laser Induced Relaxation Oscillations in Superconducting Nanobridge Single Photon Detectors
Authors: Baalbergen Frederik B. , Zadeh Iman E. , de Dood Michiel J.A
Published: September 2024

We present the first observations of laser synchronised relaxation oscillations in superconducting nanowire single photon detectors. Understanding the thermal feedback behind these oscillations aids the development of photon number resolving and higher count rate detectors.
Optimizing single mode projection techniques for high-order complex spatial modes
Authors: Ma Annameng , Goel Suraj , Valencia Natalia Herrera , McCutcheon Will , Malik Mehul
Published: September 2024

Comparing effective manipulation of transverse-spatial modes of light through single and two plane phase modulations using a re-programmable multi-plane light conversion scheme (MPLC).
Photon-pair Generation in Ordered and Disordered Arrays of Nonlinear Nanoparticles
Authors: Krasikov Sergey , Weissflog Maximilian A. , Pertsch Thomas , Setzpfandt Frank , Saravi Sina
Published: September 2024

We theoretically investigate photon-pair generation in planar arrays of point-like nonlinear sources, with periodic and disordered patterns. We investigate the pattern-dependent evolution of emission directionalities, and discover a regime for pattern-independent generation of polarization-entangled states.
Joint Spectral Characterization of Photon Pairs Generated in (Al)GaAs-on-insulator Waveguides
Authors: Leger Alexandre Z. , Ulsig Emil Z. , Stanton Eric J. , Reddy Dileep V. , Volet Nicolas , Shalm Lynden K. , Stevens Martin J. , Hamel Deny R. , Mirin Richard P.
Published: September 2024

We demonstrate spontaneous parametric downconversion in straight GaAs and AlGaAs-on-insulator waveguides, which yield a maximum pair generation rate of 1.2 × 1010s−1mW−1, normalized to the pump power. The joint spectral intensity is directly measured via time-of-flight spectroscopy.
FPGA-based Time-to-digital Converter for Quantum Key Distribution with continuous calibration
Authors: Bolaños Wagner Matías R. , Vogrig Daniele , Villoresi Paolo , Vallone Giuseppe , Stanco Andrea
Published: September 2024

In this work, we introduce a scalable, multichannel FPGA-based time-to-digital converter design for quantum key distribution. Our approach includes a non-disruptive calibration scheme, enabling continuous data acquisition and enhancing system performance.
Volume Bragg Gratings for Atomic and Quantum Applications
Authors: Glebov Alexei L. , Mokhun Oleksiy , Vasilyeu Ruslan , Smirnov Vadim
Published: September 2024

We demonstrate application of reflecting Volume Bragg Gratings (VBGs) as ultra-narrow band filters for longitudinal mode selection/cleaning of quantum light sources and highly dispersive chirped VBGs for efficient conversion of phase to amplitude modulation.
Multi-client blind quantum computing over a Qline architecture
Authors: Polacchi Beatrice , Leichtle Dominik , Limongi Leonardo , Carvacho Gonzalo , Milani Giorgio , Spagnolo Nicolò , Kaplan Marc , Sciarrino Fabio , Kashefi Elham
Published: September 2024

Blind quantum computing (BQC) was only demonstrated in single-client scenarios. Here, we design a versatile multi-client BQC on a linear network and demonstrate it in a two-client setting on an adaptive photonic platform.
Emergence of an unpredictable evolution in a spatial prisoner’s dilemma via a player’s multiple perspectives
Authors: Sakiyama Tomoko , Kojo Ken’ichi
Published: September 2024

Spatial prisoner’s dilemma (SPD) has attracted researchers’ attention as a model of conflict for players. In SPD, players have two different strategies, namely, defectors and cooperators. A defector earns a high payoff from an opponent co-operator while getting nothing from an opponent defector. On the contrary, cooperators promote a win–win relationship between the two cooperators. These mechanisms influence population dynamics in SPD, and many SPD models have been developed. However, little is known about the emergence of an unstable or unpredictable evolution in population dynamics using an SPD model, which may be observed in living systems. In addressing this issue, two SPD models were proposed. In both models, players change the neighborhood definition in accordance with their strategies and sometimes select the rule for this change using probability or local information. Result showed that our models generated characteristic population patterns that may be linked to a self-organized criticality (SOC), a term referring to many systems of interconnected, nonlinear elements that evolve over time into a critical state. In fact, the second model could be spontaneously close to the critical point using local information.
Deep neural networks integrating genomics and histopathological images for predicting stages and survival time-to-event in colon cancer
Authors: Ogundipe Olalekan , Kurt Zeyneb , Woo Wai Lok
Published: September 2024

Motivation

There exists an unexplained diverse variation within the predefined colon cancer stages using only features from either genomics or histopathological whole slide images as prognostic factors. Unraveling this variation will bring about improved staging and treatment outcomes. Hence, motivated by the advancement of Deep Neural Network (DNN) libraries and complementary factors within some genomics datasets, we aggregate atypia patterns in histopathological images with diverse carcinogenic expression from mRNA, miRNA and DNA methylation as an integrative input source into a deep neural network for colon cancer stages classification, and samples stratification into low or high-risk survival groups.

Results

The genomics-only and integrated input features return Area Under Curve–Receiver Operating Characteristic curve (AUC-ROC) of 0.97 compared with AUC-ROC of 0.78 obtained when only image features are used for the stage’s classification. A further analysis of prediction accuracy using the confusion matrix shows that the integrated features have a weakly improved accuracy of 0.08% more than the accuracy obtained with genomics features. Also, the extracted features were used to split the patients into low or high-risk survival groups. Among the 2,700 fused features, 1,836 (68%) features showed statistically significant survival probability differences in aggregating samples into either low or high between the two risk survival groups.

Availability and Implementation: https://github.com/Ogundipe-L/EDCNN
Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
Authors: Peters Karsten , Lerma Clavero Ada , Kullenberg Fredrik , Kopsida Maria , Dahlgren David , Heindryckx Femke , Lennernäs Hans , Sjöblom Markus
Published: September 2024

Cancer continues to pose a significant global health challenge, with gastrointestinal (GI) cancers among the most prevalent and deadly forms. These cancers often lead to high mortality rates and demand the use of potent cytotoxic chemotherapeutics. For example, 5-fluorouracil (5-FU) forms the backbone of chemotherapy regimens for various GI cancers, including colorectal cancer. While these chemotherapeutics efficiently kill cancer cells, they frequently cause off-target effects such as chemotherapy-induced mucositis (CIM), characterized by debilitating symptoms like pain, nausea, and diarrhoea, necessitating medical intervention. In this study, we elucidated the potential of melatonin and misoprostol to reduce 5-FU-induced small intestinal mucositis. Morphological and cellular changes in the jejunum, along with colonic faecal water content were quantified in rats as markers for CIM. Additionally, the effects of melatonin were investigated in vitro on 5-FU treated murine intestinal organoids. The results showed that melatonin prevented villus atrophy in the rat jejunal mucosa and upheld cell viability in murine intestinal organoids. In contrast, misoprostol alone or in combination with melatonin did not significantly affect CIM caused by 5-FU. These in vivo and in vitro experiments provided promising insights that melatonin may be used as a preventive and/or adjuvant combination therapy to prevent and reduce CIM, holding the potential to enhance cancer treatment outcomes and improve patient quality-of-life.
Asymmetric dynamic linkage between consumer sentiment, inflation expectations, and international energy prices: Evidence from time-frequency wavelet and nonlinear analysis
Authors: Fu Lianlian , Yuan Dongyu , Teng Jiamin
Published: September 2024

This study investigates the relationship between consumer sentiment (CONS), inflation expectations (INEX) and international energy prices, drawing on principles from behavioral. We focus on Brent crude oil price and Henry Hub natural gas prices as key indicators of energy market dynamics. Based on the monthly data from January 2003 to March 2023, three wavelet methods are applied to examine the time-frequency linkage, while the nonlinear distributed lag model (NARDL) is used to verify the asymmetric impact of two factors on energy prices. The results highlight a substantial connection between consumer sentiment, inflation expectations and international energy prices, with the former in the short term and the latter in the medium to long term. Especially, these correlations are particularly pronounced during the financial crisis and global health emergencies, such as the COVID-19 epidemic. Furthermore, we detect short-term asymmetric effects of consumer sentiment and inflation expectations on Brent crude oil price, with the negative shocks dominating. The positive effects of these factors on oil prices contribute to observed long-term asymmetry. In contrast, inflation expectations have short-term and long-run asymmetric effects on natural gas price, and both are dominated by reverse shocks, while the impact of consumer sentiment on natural gas prices appears to be less asymmetric. This study could enrich current theories on the interaction between the international energy market and serve as a supplement to current literature.
Urine metabolomic profiles of autism and autistic traits–A twin study
Authors: Arora Abishek , Mastropasqua Francesca , Bölte Sven , Tammimies Kristiina
Published: September 2024

Currently, there are no reliable biomarkers for autism diagnosis. The heterogeneity of autism and several co-occurring conditions are key challenges to establishing these. Here, we used untargeted mass spectrometry-based urine metabolomics to investigate metabolic differences for autism diagnosis and autistic traits in a well-characterized twin cohort (N = 105). We identified 208 metabolites in the urine samples of the twins. No clear, significant metabolic drivers for autism diagnosis were detected when controlling for other neurodevelopmental conditions. However, we identified nominally significant changes for several metabolites. For instance, phenylpyruvate (p = 0.019) and taurine (p = 0.032) were elevated in the autism group, while carnitine (p = 0.047) was reduced. We furthermore accounted for the shared factors, such as genetics within the twin pairs, and report additional metabolite differences. Based on the nominally significant metabolites for autism diagnosis, the arginine and proline metabolism pathway (p = 0.024) was enriched. We also investigated the association between quantitative autistic traits, as measured by the Social Responsiveness Scale 2nd Edition, and metabolite differences, identifying a greater number of nominally significant metabolites and pathways. A significant positive association between indole-3-acetate and autistic traits was observed within the twin pairs (adjusted p = 0.031). The utility of urine biomarkers in autism, therefore, remains unclear, with mixed findings from different study populations.
Temporal trends (1972–2017) and spatial differences of persistent halogenated aromatic hydrocarbons in osprey eggs in Finland
Authors: Viluksela Matti , Saurola Pertti , Koivusaari Juhani , Finnlund Matts , Bignert Anders , Airaksinen Riikka , Ruokojärvi Päivi , Verta Matti , Kiviranta Hannu , Tuomisto Jouni T. , Rantakokko Panu
Published: September 2024

Time trends and regional differences of polychlorinated dibenzo-p-dioxins and -furans (PCDD/Fs), polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs), DDTs, polybrominated biphenyls (PBBs) and polybrominated diphenylethers (BDEs) were studied in unhatched osprey eggs collected by bird ringers in 1972–2017 from four areas in Finland. Two study areas were from Baltic Sea, Northern Quark and Finnish Archipelago Sea, while the two others were inland lake areas, eutrophicated Lake Vanajanselkä affected by industrial emissions, and Pristine SW Lake Area. The highest concentrations of most compound groups were in Lake Vanajanselkä consistent with high emissions, the predominance of bream as a prey, and higher concentrations in bream compared to other prey fish. Concentrations of all chlorinated compounds decreased significantly in all study areas. Average annual decreases were ∑PCDD/F 2.3–4.9%, ∑PCB 2.2–4.2%, ∑PCN 2.6–7.0% and ∑DDT 7.1–9.5%, primarily in line with decreased levels in prey fish. From 1972 PBBs and BDEs increased significantly until 1990s declining rapidly thereafter. PCDD/F congener profile was dominated by 2,3,4,7,8-PeCDF, except in Lake Vanajanselkä by 1,2,3,6,7,8-HxCDD. PCB congener profile was dominated by PCB 153 in all study areas, followed by PCB 180 and PCB 138. Among dioxin-like compounds PCBs contributed 82%, PCDDs 14% and PCDFs 4% to toxic equivalent quantity (∑TEQ). PCB 126 contributed most to ∑TEQ, followed by 1,2,3,7,8-PeCDD. BDE 47 being the dominant BDE congener, followed by BDE 100. ∑DDT concentrations were relatively similar across all study areas, with DDE contributing about 90%. Productivity of chicks per active nest was significantly decreased in Lake Vanajanselkä, and the likely explanation is embryotoxicity of dioxin-like compounds. It is plausible that dioxin-like compounds influenced embryonic survival among highly exposed ospreys prior to 2010, especially in Lake Vanajanselkä and Northern Quark. However, decreased survival due to DDE-induced eggshell thinning seems unlikely after 1985, and BDE levels were below those potentially causing adverse effects.
Self-stigmatization and treatment preferences: Measuring the impact of treatment labels on choices for depression medications
Authors: Gonzalez Sepulveda Juan Marcos , Townsend Michael , Waters Heidi C. , Brubaker Maalak , Wallace Matthew , Johnson Reed
Published: September 2024

Objective

To collect evidence on the possibility that patients with depression experience self-stigmatization based on label information for medications.

Methods

We developed a discrete-choice experiment (DCE) survey instrument that asked respondents to make choices between hypothetical treatments for major depressive disorder (MDD). We also included treatment type (antidepressants versus antipsychotics) and approved indications for the medication. The choice questions mimicked the information presented in product inserts and required systematic tradeoffs between treatment efficacy, treatment type, and indication. We calculated how many patients were willing to forgo efficacy to avoid treatments with information associated with self-stigmatization, and how much efficacy they were willing to forgo. We also evaluated the impact of contextualizing the treatment information to reduce self-stigmatization by randomizing respondents who received additional context.

Results

A total of 501 patients with MDD were recruited to complete the DCE survey. Respondents had well-defined preferences for treatment outcomes. Over 60% (63.4%) of respondents were found to be significantly affected by treatment indication. These respondents were willing to forgo about 2.5 percentage points in the chance of treatment efficacy to avoid treatments indicated for schizophrenia. We also find that some level of contextualization of the treatment details could help reduce the negative impact of treatment type and indications.

Conclusions

Product-label treatment indication can potentially lead to patient self-stigmatization as shown by patients’ avoidance of treatments that are also used to treat schizophrenia. While the effect appears to be relatively small, results suggests that the issue is likely pervasive.
Impact of music learning on students’ psychological development with mediating role of self-efficacy and self-esteem
Authors: Jiang Jing
Published: September 2024

Professionals and academics have recently placed a greater emphasis on comprehending the elements that go into improving students’ psychological wellbeing. Students frequently face major obstacles as a result of the rigorous nature of academic life, which can result in problems like tension, depression and other psychological health concerns. These complications have a long-lasting influence on their future aspirations in addition to affecting their academic achievement. This study determined the effects of music learning on students’ academic performance and psychological well-being. The mediating role of self-efficacy and self-esteem are also examined in this study. The data is collected from 326 students in Chinese universities and applied structural equation modeling for empirical analysis. The findings show that music education improves the students’ psychological well-being, which in turn improves their academic performance. Additionally, psychological health is a major factor in improving the academic performance. There is significant mediating impact of self-efficacy and self-esteem in relationship between mental well-being and music education. To improve students’ psychological health, it is suggested that policy makers should consider the integration of music education into academic settings.
Increased Susceptibility of WHIM Mice to Papillomavirus-induced Disease is Dependent upon Immune Cell Dysfunction
Authors: Wang Wei , Pope Ali , Ward-Shaw Ella , Buehler Darya , Bachelerie Francoise , Lambert Paul F.
Published: September 2024

Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome is a rare primary immunodeficiency disease in humans caused by a gain of function in CXCR4, mostly due to inherited heterozygous mutations in CXCR4. One major clinical symptom of WHIM patients is their high susceptibility to human papillomavirus (HPV) induced disease, such as warts. Persistent high risk HPV infections cause 5% of all human cancers, including cervical, anogenital, head and neck and some skin cancers. WHIM mice bearing the same mutation identified in WHIM patients were created to study the underlying causes for the symptoms manifest in patients suffering from the WHIM syndrome. Using murine papillomavirus (MmuPV1) as an infection model in mice for HPV-induced disease, we demonstrate that WHIM mice are more susceptible to MmuPV1-induced warts (papillomas) compared to wild type mice. Namely, the incidence of papillomas is higher in WHIM mice compared to wild type mice when mice are exposed to low doses of MmuPV1. MmuPV1 infection facilitated both myeloid and lymphoid cell mobilization in the blood of wild type mice but not in WHIM mice. Higher incidence and larger size of papillomas in WHIM mice correlated with lower abundance of infiltrating T cells within the papillomas. Finally, we demonstrate that transplantation of bone marrow from wild type mice into WHIM mice normalized the incidence and size of papillomas, consistent with the WHIM mutation in hematopoietic cells contributing to higher susceptibility of WHIM mice to MmuPV1-induced disease. Our results provide evidence that MmuPV1 infection in WHIM mice is a powerful preclinical infectious model to investigate treatment options for alleviating papillomavirus infections in WHIM syndrome.
Phosphorylated vimentin-triggered fibronectin matrix disaggregation enhances the dissemination of Treponema pallidum subsp. pallidum across the microvascular endothelial barrier
Authors: Luo Xi , Zhang Litian , Xie Xiaoyuan , Yuan Liyan , Shi Yanqiang , Jiang Yinbo , Ke Wujian , Yang Bin
Published: September 2024

Fibronectin (FN) is an essential component of the extracellular matrix (ECM) that protects the integrity of the microvascular endothelial barrier (MEB). However, Treponema pallidum subsp. pallidum (Tp) breaches this barrier through elusive mechanisms and rapidly disseminates throughout the host. We aimed to understand the impact of Tp on the surrounding FN matrix of MEB and the underlying mechanisms of this effect. In this study, immunofluorescence assays (IF) were conducted to assess the integrity of the FN matrix surrounding human microvascular endothelial cell-1 (HMEC-1) with/without Tp co-culture, revealing that only live Tp exhibited the capability to mediate FN matrix disaggregation in HMEC-1. Western blotting and IF were employed to determine the protein levels associated with the FN matrix during Tp infection, which showed the unaltered protein levels of total FN and its receptor integrin α5β1, along with reduced insoluble FN and increased soluble FN. Simultaneously, the integrin α5β1-binding protein–intracellular vimentin maintained a stable total protein level while exhibiting an increase in the soluble form, specifically mediated by the phosphorylation of its 39th residue (pSer39-vimentin). Besides, this process of vimentin phosphorylation, which could be hindered by a serine-to-alanine mutation or inhibition of phosphorylated-AKT1 (pAKT1), promoted intracellular vimentin rearrangement and FN matrix disaggregation. Moreover, within the introduction of additional cellular FN rather than other Tp-adhered ECM protein, in vitro endothelial barrier traversal experiment and in vivo syphilitic infectivity test demonstrated that viable Tp was effectively prevented from penetrating the in vitro MEB or disseminating in Tp-challenged rabbits. This investigation revealed the active pAKT1/pSer39-vimentin signal triggered by live Tp to expedite the disaggregation of the FN matrix and highlighted the importance of FN matrix stability in syphilis, thereby providing a novel perspective on ECM disruption mechanisms that facilitate Tp dissemination across the MEB.
Singing the Psyche: Uniting Thought and Feeling through the Voice: Voice Movement Therapy in Practice, Anne M. Brownell, Deirdre A. Brownell and Gina H. Mulder (eds) (2023)
Authors: Rees Hannah
Published: September 2024

Review of: Singing the Psyche: Uniting Thought and Feeling through the Voice: Voice Movement Therapy in Practice, Anne M. Brownell, Deirdre A. Brownell and Gina H. Mulder (eds) (2023)

Springfield, IL: Charles C Thomas Publisher, 320 pp.,

ISBN 978-0-39809-424-9, p/bk, $28.95
Development and Validation of a Mobile Application for Early Childhood Nutrition Monitoring: A Multisensor-Based Non-Contact Anthropometric System
Authors: Yafie Evania , Pramono  , Sutama I Wayan , Samawi Ahmad , Khairuddin Khairul Farhah Binti , Asyhari Rahayu
Published: September 2024

The issue of early childhood nutrition in Indonesia, including the high prevalence of stunting, is of critical importance as it can permanently impair children's physical growth and cognitive development. Parents frequently encounter challenges in accurately and consistently monitoring their children's nutritional status, which impedes the early detection of nutritional issues. This study introduces the Multisensor-Based Non-Contact Anthropometric System (MB-NCAS), a mobile application developed to monitor nutritional status and detect stunting in early childhood. The research encompassed five phases using a modified ADDIE model: Analysis, Design, Development, Implementation, and Evaluation. In the Analysis phase, parent questionnaires identified critical nutritional needs and challenges related to stunting. The Design phase focused on setting clear objectives and developing educational content for the app. The Development phase saw the app's creation, which experts in content accuracy, media design, and instructional strategies subsequently validated. During the Implementation phase, the app was tested with parents in Malang City, who participated in pretest and posttest evaluations to assess the app's practicality and effectiveness.  The results indicated significant improvements in parental knowledge and skills in monitoring child nutrition and stunting, with expert validation scores averaging 92.6% for media design, 86.25% for material content, and 87.28% for instructional design. The MB-NCAS app is a valid, reliable, and practical tool for early childhood nutrition monitoring. However, challenges such as limited technology access in certain areas may hinder its broader application. Future research should explore the app's effectiveness in diverse settings and focus on improving technology accessibility to enhance its impact on public health.
How Microfinance Financializes Women
Authors: Zhang Jingyi
Published: September 2024

Reviewing Smitha Radhakrishnan's Making Women Pay, Jingyi Zhang elucidates the exploitative practices of the much-vaunted microfinance industry, particularly as they apply to—and exacerbate—existing tensions within communities of women in India.
Education policy intentions and principals’ and teachers’ conceptualizations of curriculum differentiation in Ethiopian secondary education
Authors: Tarekegn Kagnew , Mihiretie Dawit Mekonnen
Published: September 2024

This study examined the intentions of education policy documents and the conceptualizations of secondary school principals and teachers regarding curriculum differentiation. Regular and special day schools were selected using purposive sampling based on their experiences with different types of curriculum differentiation. Two school principals and 17 subject teachers were selected using purposive and convenience samplings, respectively. The study analyzed national education policy documents (e.g., education and training policy and curriculum framework) and collected interview data from school principals and teachers. The two main national education policy documents conceptualize curriculum differentiation in terms of various tracks, like fields of study, streams, and school types. The other national document, the guideline for curriculum differentiation, emphasizes the differentiation of curriculum components—contents, instructional processes, assessment strategies, and learning environments—and highlights the importance of inclusive classrooms. Principals’ and teachers’ conceptualizations of curriculum differentiation vary across three levels: lacking awareness, holding divergent views, and aligning with policy intentions. The absence of a coherent policy guide and the lack of engagement of principals and teachers in reform ideas have contributed to these diverse conceptualizations. Additionally, the policy intentions seem inadequately addressed through curriculum differentiation practice by school types, such as regular, special day, and boarding schools, which do not correspond to variations in the types and levels of difficulty of the school subjects taught.
Landwirtschaft und Energiewende: Neue Synergien für mehr Klimaschutz
Authors: Bluhm Hannes , Rupp Johannes
Published: September 2024

Einführung in das Schwerpunktthema
Estudio descriptivo de las enfermedades raras visuales en España
Authors: Peñalver García Dolores María , Navarro Gómez Carmen Mª , García Recover Pedro
Published: September 2024

El Grupo de Investigación en Enfermedades Raras Visuales (GISERV) pertenece a la Asociación Retina Murcia. En este Estudio presentamos el primer informe en España acerca del acceso a diagnóstico clínico y genético, así como el impacto social en el día a día de las personas afectadas por alguna de estas patologías que limitan la visión. Hemos puesto atención en los recursos que tienen estas personas en nuestro país y tras el análisis, aportamos una serie de propuestas de mejora.
Libre desarrollo de la personalidad y desnaturalización de los derechos humanos: su banalización exponencial
Authors: Ávila Hernandez Flor María , De Los Santos olivo Isidro , Peralta Martínez Angel Ramón
Published: September 2024

La propuesta tiene como objeto el estudio del concepto “libre desarrollo de la personalidad” y sus implicaciones jurídicas como principio objetivo y derecho subjetivo intrínsecamente relacionado con los derechos y la dignidad humanos, así como el análisis de la reciente crisis axiológica y la banalización de las libertades públicas en el Estado constitucional de derecho. Se emplean los métodos analítico, crítico-valorativo e histórico, entre otros, sin soslayar la dogmática constitucional, como base de la teoría de la Constitución. Se concluye que el concepto del libre desarrollo de la personalidad no es un derecho absoluto, cuyas limitantes se prescriben en las Constituciones, de las cuales se toman como referentes la alemana y la española. Considerados paradigmáticos los derechos fundamentales, se contrasta su actual proliferación desmesurada y su vaciamiento axiológico que los identifica y esencializa. Lo anterior se asume como la principal causa de la crisis por la que atraviesan, que produce el fenómeno de la desconstitucionalización. Asimismo, se concluye que las libertades se deben concebir y, ejercer racionalmente con mesura, pero, sobre todo, con responsabilidad.
Horizontal Transition of Expertise
Authors: Gegenfurtner Andreas , Gruber Hans , Lehtinen Erno , Säljö Roger
Published: September 2024

Expert performance in a domain is often defined as maximal adaptation to stable task constraints. This definition is useful when analyzing the vertical transition when novices become experts. However, many workplaces undergo considerable changes and, thus, task constraints change as well. In this paper, a complementary conceptualization of expertise is offered, one that focuses on expert performance as recurring adaptation to dynamic task constraints. This definition is useful when analyzing the horizontal transition when experts adapt to dynamically changing work contexts. Using the documentary method, the aim of the present study was to analyze cases of horizontal transitions based on qualitative biographical interview data from five experts reconstructing different types of adaptation to technological change in their domains that they have experienced. Implications for studying horizontal transitions at dynamic worksites are discussed.
Introduction: Touching Troy
Authors: Johnston Andrew James , Keller Wolfram R. , Ravenhall Henry
Published: September 2024

This introduction aims to briefly sketch the theoretical framework for the articles assembled in this special issue on touch within the transmission of the Troy story in western Europe. Starting with the analysis of an important scene involving reading and manuscript culture in Geoffrey Chaucer’s Troilus and Criseyde, this introduction provides a context for medieval instances of touching within contemporary thinking about materiality and relationality and within the transmission of the Troy story in late medieval and early modern Europe.
新漢語水平考試應試輔導教材對比分析: 以中韓兩國 HSK 三級為例
Authors: 容玥 杜 , 玟荣 河
Published: September 2024

本文探討新漢語水平考試應試教材之分析, 選取中韓兩國出版之新 HSK3 級應試輔導教材《HSK 標準教程 3》與《使用一本書通過新 HSK3 級》進行對比分析, 這兩套教材分別為中韓兩國具影響力的華語教材。本研究根據新 HSK 考試大綱, 針對兩套教材, 從整體編排、詞彙和語法、課文及練習等方面進行分析, 並且探討韓國學習者的語言背景、選擇華語教材的偏好、應試教材的影響力等。選取 HSK 三級這個等級作為探究主題是由於 HSK 三級往往為華語學習者學習歷程的轉捩點, 有些人會繼續學習通過四級, 但有些人則不再繼續, 因此 HSK 三級應試教材在華語學習階段中扮演了重要的角色。本文透過兩套教材的比較以及分析問卷調查的結果, 從中發現二者的個性與共性, 希冀能為韓國國內的華語學習者提供選用教材的參考指標, 並從教材開發與編寫的角度提出以下建議: 一、增加漢字分析的內容, 比如易混淆字、繁簡字等; 二、調整教材編寫的整體結構和版式設計; 三、增加與新 HSK 真題有關的模擬題, 以利於學習者掌握漢語水準考試的形式; 四、增加文本閱讀的詞語切分、句子斷句等內容, 增強學習者對華語詞彙的知識; 五、針對性地在華語教材中專門設置類似「提醒」板塊或環節, 增加華語和韓語之語言特徵對比的內容。本研究旨在幫助華語學習者增進應試技巧, 同時能在實際使用華語時能對自己的偏誤予以改進, 避免犯一些特有的「韓式」發音或語法錯誤, 進而提高華語交際能力。
Imagining an Alternative Future: Children’s Bodies in Wonder Boy (1988), Magic Watch (1990), and Mad Rabbit (1997)
Authors: Liang Shuang
Published: September 2024

Since China launched its reform and opening-up campaign, the country experienced significant economic growth and infrastructure expansion, which helped spur the release of numerous science fiction works. Among these works, Zhang Zhilu’s three children’s sf films presented an alternative future for Chinese children and teenagers. This essay contends that while these films portray children as integral to infrastructure and the construction of a market economy network, they opt for natural and playful growth driven by a longing for freedom and emotional connection, and by doing so they circumvent the predetermined and goal-oriented trajectory of social development.
How individuals cope with anger- and sadness-induced narrative misinformation on social media: roles of transportation and correction
Authors: Zhao Xinyan , Shaw Jessica , Ma Zexin
Published: September 2024

Purpose

The spread of health conspiracies and misinformation online threatens public health as most Americans choose to acquire health information online. This study examines how discrete emotions like anger and sadness influence individuals’ responses to narrative-based health misinformation, proposing a theoretical model of narrative misinformation coping and exploring the mechanisms through which these emotions affect risk perception and misinformation coping.

Design/methodology/approach

Through a 2 (Misinformation type: narrative vs. non-narrative) × 2 (Issue: climate change vs. fentanyl overdose) × 2 (Correction: present vs. absent) online experiment (N = 401), our results underscore the importance of both risk coping and misinformation coping in individuals’ responses to emotional narrative misinformation, along with the role of narrative transportation in intensifying felt emotions and facilitating both types of coping.

Findings

Our results elucidate how individuals cope with anger- and sadness-induced narrative misinformation. Specifically, sadness decreases susceptibility to narrative misinformation’s negative effects, and anger prompts intuitive actions. Narrative transportation deepened felt emotions and both coping processes, and corrections reduced the perceived truthfulness of misinformation.

Practical implications

Our findings offer practical strategies for mitigating misinformation by disrupting narrative transportation, particularly for anger-induced stories.

Social implications

Our findings can contribute to the development of targeted policies aimed at mitigating online misinformation dissemination and provide a roadmap to executing effective correction measures.

Originality/value

This study proposes and tests a theoretical model of people’s responses to narrative misinformation addressing both misinformation coping and risk coping through cognitive and behavioral routes. The model also explains how transportation, along with different appraisal tendencies, can intensify both coping processes.
Die Bedeutung der Grenze für die Heil- und Sonderpädagogik
Authors: Seitzer Philipp
Published: September 2024

Der folgende Beitrag untersucht die Grenze als pädagogischanthropologische Reflexionsfigur und deren Bedeutung für das Selbstverständnis und die Programmatik der Heil- und Sonderpädagogik. In diesem Zusammenhang wird auch die Frage gestellt, ob die Kritik, die innerhalb der Allgemeinen Pädagogik unter dem Stichwort „Optimierung als Entgrenzung“ formuliert wird, in ihrer Anwendung auf die Heil- und Sonderpädagogik Differenzierungen erfordert, die auch die fragliche Differenz dieser beiden Disziplinen tangieren. Nachdem in der Einleitung auf Optimierung eingegangen wird, ist im zweiten Schritt zunächst auf die Figur der Grenze unter pädagogischanthropologischen Aspekten einzugehen, ehe im dritten Schritt die Kritik der Entgrenzung konkretisiert wird. Anschließend wird das Verhältnis des heil- und sonderpädagogischen Diskurses zur Figur der Grenze befragt. Dies geschieht im Rahmen einer schlaglichtartigen historischsystematischen Untersuchung. Im Verlauf dieser Untersuchung lassen sich bestimmte Fragen, Probleme und Entwicklungslinien herausarbeiten, auf die im abschließenden Fazit Bezug genommen wird. Dieses gibt zudem einen Ausblick, wie mit offenen Problemen im Zusammenhang mit der Figur der Grenze in heil- und sonderpädagogischen Diskursen der Gegenwart umgegangen werden kann.
[113mIn]In-PSMA: high potential agent for SPECT imaging of prostate cancer
Authors: Akbari Leyla , Sina Sedigheh , Zolghadri Samaneh , Moghaddasi Ali , Hadad Kamal , Yousefnia Hassan
Published: September 2024

The prevalence rate of prostate cancer is very high and unfortunately causes many deaths worldwide. This study aimed to prepare [113mIn]In-PSMA as a novel agent for single photon emission computed tomography (SPECT) imaging of prostate cancer. 113mIn was eluted from an in-house made 113Sn/113mIn generator in chloride form, and its radionuclide, chemical and radiochemical purities was studied. [113mIn]In-PSMA was prepared with radiochemical purity (RCP) > 99 % under optimal labeling conditions. The biodistribution of the labeled compound was studied in normal rats, showed the major activity in the urine and kidneys as the main excretion route from the body. Considerable uptake was observed in the prostate and salivary glands as the PSMA-expressing organs. These data are in complete agreement with the other published data on PSMA-labeled compounds both in animals and humans. The results demonstrated [113mIn]In-PSMA can be considered as a good option for SPECT imaging of prostate cancer.
Efficacy and safety of sulforaphane-loaded emulsomes as tested on MCF7 and MCF10A cells
Authors: Karroum Reem , Üçışık Mehmet Hikmet
Published: September 2024

Objectives

Sulforaphane is well-known for its anti-cancer properties particularly against breast, skin and prostate cancers. High sensitivity of sulforaphane to oxygen, heat, and alkaline conditions, as well as its poor oral bioavailability and water instability limit its use in medicine. In this study, we aim to overcome the prementioned limitations by encapsulating sulforaphane within a lipid-based drug delivery system, known as emulsome, and investigate the anti-cancer features of the attained formulation.

Methods

The stability and dispersity of the formulation were assessed sequentially by zeta sizer, scanning electron microscopy and confocal laser scanning microscopy. Cell culture studies were performed to evaluate the anticancer activity of the formulation.

Results

Sulforaphane-loaded emulsomes with an average particle size of 246.0±14.1 nm, an average zeta potential of −23.5±2.4 mV and a polydispersity index of around 0.38 were produced. Encapsulations up to 0.036 mg/mL sulforaphane concentration was achieved. When MCF7 breast cancer cells were treated with sulforaphane-loaded emulsomes, a significant decrease was observed in proliferation of the cells along 72 h. In control group, emulsomes were found safe as tested at same concentrations on MCF-10a healthy cells. Applied as dissolved in DMSO, free sulforaphane with an IC50 value of 1.2 µM was more effective against MCF7 cells than sulforaphane-loaded emulsome formulation having a IC50 value 21.1 µM.

Conclusions

Sulforaphane-loaded emulsomes were obtained as stable, moderately disperse suspensions. Delivery of the bioactive compound into the cells were achieved. Yet, its biological activity remained behind its free form.
Stories of Skills and Values: What Therapists Can Learn From Autistic Young People in Mumbai, India
Authors: Sanghvi Jill , Sawatzky Donald
Published: September 2024

Research on autism in the past two decades has primarily focused on medical characteristics and psychological consequences. What remains largely undocumented are the lived experiences of autistic young people. The current study explores the skills and values of autistic young people in the Indian context from the first-person perspective. The inquiry was guided by narrative inquiry and dialogical narrative analysis, embedded in the social constructionist framework. Six autistic young people, between 10 and 18 years old, were interviewed; analysis of the results brought forth four commonalities of skills and values: (1) diverse understandings of autism; (2) understanding social situations, their own needs, and others’ responses; (3) thinking outside the box; and (4) helping and caring for others. Rather than having a diagnosis of autism labeled as a deficit, these findings open up possibilities for therapy work to look different by supporting people to hold on to their identity as autistic people.
How Questioning Functions in Co-construction
Authors: De Jong Peter , Healing Sara , Jordan Sara Smock
Published: September 2024

This microanalysis study extends our understanding of how questioning works in a face-to-face dialogue. It does so, first, by testing the central proposition of McGee's (1999) co-constructive model of questions on a body of experimental data. It does so, secondly, by demonstrating how the questions and formulations (paraphrases and summaries) of an interviewer are skillfully interwoven in co-constructive sequences designed to invite the interviewee to construct ever more detailed understandings around a topic introduced by the interviewer in an opening and overarching question to the sequence. The implications for social constructionism and doing therapy are discussed.
Artificial Leadership - Teil 1
Authors: Kollmann Tobias , Kollmann Kilian , Kollmann Niklas
Published: September 2024

Der rasante Fortschritt in der formativen und transformativen Leistung einer Künstlichen Intelligenz (KI) wird ein neues Einsatzfeld im Rahmen der Unternehmensführung determinieren. Dabei wird die KI nicht mehr nur als „Unterstützungstool“ für einen Arbeitnehmer eingesetzt werden, sondern zukünftig auch als „Entscheidungsinstanz“ gegenüber diesem Arbeitnehmer auftreten und diesem auch die daraus resultierenden Arbeitsanweisungen erteilen. Dies führt unmittelbar zu der Frage, wo und wie werden KI-Systeme in welchen Bereichen bestimmte Führungsaufgaben übernehmen?
Krankenversicherung für Studierende
Authors: Michelsen Miriam
Published: September 2024

Eine passende Krankenversicherung ist unverzichtbar für die langfristige Absicherung der Gesundheit und die damit einhergehenden Pläne für die Zukunft. Zudem ist eine bestehende Krankenversicherung Voraussetzung für die Immatrikulation an einer deutschen Hochschule, und auch im Falle von Auslandssemestern oder Reisen müssen spezielle Vorkehrungen getroffen werden. Dieser Artikel gibt einen Überblick über Krankenversicherungen für Studierende und erläutert die wichtigsten Besonderheiten.
Artificial Leadership - Teil 2
Authors: Kollmann Tobias , Kollmann Kilian , Kollmann Niklas
Published: September 2024

Der rasante Fortschritt in der formativen und transformativen Leistung einer Künstlichen Intelligenz (KI) wird ein neues Einsatzfeld im Rahmen der Unternehmensführung determinieren. Dabei wird die KI nicht mehr nur als „Unterstützungstool“ für einen Arbeitnehmer eingesetzt werden, sondern zukünftig auch als „Entscheidungsinstanz“ gegenüber diesem Arbeitnehmer auftreten und diesem auch die daraus resultierenden Arbeitsanweisungen erteilen. Dies führt unmittelbar zu der Frage: Wo und wie werden KI-Systeme in welchen Bereichen bestimmte Führungsaufgaben übernehmen?
Dez anos de formação superior de tradutores intérpretes de Língua Brasileira de Sinais: uma experiência capixaba
Authors: Vieira-Machado Leonardo Lúcio , Matos da Costa Vieira-Machado Lucyenne
Published: September 2024

Este artículo surgió de una propuesta para el “Congreso Internacional Lengua de Señas para todos: enseñanza e interculturalidad”, celebrado el 2023 por la Universidad Nacional Mayor de San Marcos (Lima, Perú). Se busca trazar la trayectoria de un curso de enseñanza superior, desde sus orígenes hasta su proyección pública, de modo que se conectan sus raíces personales y locales con la política que culminó en la creación de la licenciatura en Traducción e Interpretación de Lengua de Señas Brasileña/Lengua Portuguesa (Letras-Libras) en la Universidad Federal de Espírito Santo (Vitória, Brasil). Nuestro objetivo es analizar el impacto del Proyecto Pedagógico de Curso (PPC) en la formación de profesionales reflexivos y autónomos, utilizando la metodología de análisis documental de los Trabajos de Fin de Curso (TCC). Los resultados ponen de manifiesto la influencia positiva del PPC en la formación de los estudiantes, como demuestran las ocho líneas de investigación identificadas por los autores a lo largo de la primera década del curso, que se han ido adaptando progresivamente a las exigencias contemporáneas del ámbito de latraducción y la interpretación, tal y como identifican Cruz et al. (2022). En conclusión, se destaca la importancia del PPC en la construcción de un curso de excelencia y la relevancia de Letras-Libras/Ufes en la formación de profesionales comprometidos con la accesibilidad lingüística en el estado de Espírito Santo y en Brasil.
On differential geometry of tangent and cotangent bundles of Riemannian manifold
Authors: Baškienė Angelė
Published: September 2024

There is not abstract.
The Lithuanian school for young mathematicians: reality and perspective
Authors: Apynis Antanas , Stankus Eugenijus , Šinkūnas Juozas
Published: September 2024

The history and survey of the activity of the Lithuanian school for young mathematicians is presented.
Asymptotical analysis of maxima with a random number of component variables
Authors: Aksomaitis Algimantas
Published: September 2024

Estimates of the convergence rate in the transference theorem are presented. They generalize and make more precise results obtained in [2] and [3].
Cubic Legendre symbol
Authors: Markšaitis Hamletas
Published: September 2024

There is not abstract.
Principles of Creating an Electronic Catalog of Graphics Based on the Manuscripts of F. M. Dostoevsky
Authors: Tarasova Natalia
Published: September 2024

The article substantiates the principles of studying the graphic content of Dostoevsky᾽s handwritten texts and creating an electronic catalog of graphic samples that would include the most representative examples of the writer᾽s handwriting and their scientific description. The research material is Dostoevsky᾽s workbooks, which include entries of various kinds: rough sketches for artistic and journalistic ideas, letter drafts, notes for memory, addresses, calculations related to household and editorial and publishing . The variety of the material under study allows us to collect more informative and complete data on the specifics of graphic characteristics in the writer᾽s texts. The analysis and systematization of handwriting features, typical and atypical handwriting, are productive in deciphering the so-called “difficult readings” and are important for understanding the semantic context of Dostoevsky᾽s recordings, in some cases allowing to clarify important factual information. The practical value of the research lies in the possibility of using the data obtained in the study of hard-to-read handwriting, illegible spellings, as well as in the analysis of non-verbal forms of Dostoevsky᾽s graphics and their role in the creative process of the author. To solve these problems, a special toolkit has been developed that allows for the research selection of graphic images and their description.