bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S1 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Authors: Mudduluru Giridhar , Abba Mohammed , Batliner Jasmin , Patil Nitin , Scharp Maike , Lunavat Taral R. , Leupold Jörg Hendrik , Oleksiuk Olga , Juraeva Dilafruz , Thiele Wilko , Rothley Melanie , Benner Axel , Ben-Neriah Yinon , Sleeman Jonathan , Allgayer Heike
Published: April 2023

Supplementary Table S1. Microarray analysis.
Supplementary Figure S1 from Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth
Authors: Ito-Kureha Taku , Koshikawa Naohiko , Yamamoto Mizuki , Semba Kentaro , Yamaguchi Noritaka , Yamamoto Tadashi , Seiki Motoharu , Inoue Jun-ichiro
Published: April 2023

Supplementary Figure S1. TMOD1 expression is directly regulated by NF-κB activation.
Supplementary Materials and Methods from Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach
Authors: Cerasuolo Marianna , Paris Debora , Iannotti Fabio A. , Melck Dominique , Verde Roberta , Mazzarella Enrico , Motta Andrea , Ligresti Alessia
Published: April 2023

Supplementary Materials and Methods
Supplementary Figure 3 from Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging
Authors: Bachawal Sunitha V. , Jensen Kristin C. , Wilson Katheryne E. , Tian Lu , Lutz Amelie M. , Willmann Jürgen K.
Published: April 2023

Supplementary Figure 3. Binding Specificity of MBB7-H3
Supplementary Tables S4-S10 for Dang et al from ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program
Authors: Dang Tuyen T. , Esparza Matthew A. , Maine Erin A. , Westcott Jill M. , Pearson Gray W.
Published: April 2023

Supplementary tables related to miRNA and mRNA expression analysis.
Supplemetal Material and Methods, Figure 1-7 and Table 1 from Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer
Authors: Stoepker Chantal , Ameziane Najim , van der Lelij Petra , Kooi Irsan E. , Oostra Anneke B. , Rooimans Martin A. , van Mil Saskia E. , Brink Arjen , Dietrich Ralf , Balk Jesper A. , Ylstra Bauke , Joenje Hans , Feller Stephan M. , Brakenhoff Ruud H.
Published: April 2023

Supplemental Material and Methods. Supplemental Figure S1. Cell cycle analysis in FA and sporadic HNSCC cell lines upon ICL treatment. Supplemental Figure S2. FANCM protein expression is absent in FaDu cells. Supplemental Figure S3. Overview of possible pathogenic variants in genes that are frequently altered in HNSCC. Supplemental Figure S4. PARP inhibitor resistance and normal RAD51 focus formation in VU-SCC-147. Supplemental Figure S5. Cell line UPCI-SCC-154 is sensitive to cisplatin. Supplemental Figure S6. Cell line VU-SCC-41 is mutated in PSC5A. Supplemental Figure S7. Mutational inactivation of STAG2 in cell line VU-SCC-78. Supplemental Table 1. Separate panel of 39 sporadic HNSCC cell lines.
Supplementary Figure S1 from Early Prediction of Disease Progression in Small Cell Lung Cancer: Toward Model-Based Personalized Medicine in Oncology
Authors: Buil-Bruna Núria , Sahota Tarjinder , López-Picazo José-María , Moreno-Jiménez Marta , Martín-Algarra Salvador , Ribba Benjamin , Trocóniz Iñaki F.
Published: April 2023

LDH (upper panels) and NSE (lower panels) individual log-transformed concentration-time profiles from training dataset (left panels) and external dataset (right panels). Thick lines are loess smooth of the data and dashed gray lines represent the threshold normal values of each biomarker.
Supplementary Figure Legends from Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity
Authors: Mussai Francis , Egan Sharon , Hunter Stuart , Webber Hannah , Fisher Jonathan , Wheat Rachel , McConville Carmel , Sbirkov Yordan , Wheeler Kate , Bendle Gavin , Petrie Kevin , Anderson John , Chesler Louis , De Santo Carmela
Published: April 2023

Supplementary Figure Legends. Supplementary Figure Legends for Supp Figs 1-5 Contains Legends for: Supplementary Figure 1: Arginase II is the principal arginase isoform in neuroblastoma Supplementary Figure 2: Arginase II expression by neuroblastoma tumours creates a suppressive microenvironment Supplementary Figure 3: Neuroblastoma alters myeloid cell frequency in a murine model Supplementary Figure 4: Neuroblastoma arginase inactivates CD14+ cells and CAR T cells Supplementary Figure 5: Arginase 2 and CD14 expression are associated with a worse overall survival.
Supplemental Figure S6 from Metastatic Heterogeneity of Breast Cancer Cells Is Associated with Expression of a Heterogeneous TGFβ-Activating miR424–503 Gene Cluster
Authors: Li Yun , Li Wei , Ying Zhe , Tian Han , Zhu Xun , Li Jun , Li Mengfeng
Published: April 2023

Supplemental Figure S6. Quantitative PCR (qPCR) analysis of Smad7 or Smurf2 expression in response to transfection of various oligonucleotides overexpressing or inhibiting miR-424/miR-503.
Supplementary Figure Legend from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Supplementary Figure Legend
Supplementary Figure 8 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Western blot analysis for cleaved PARP and cleaved caspase 3 of all chordoma cell lines as compared to HEK-293 cells (+/- stimulation with TNFÎ± and Bortezomib for 18h). No corresponding bands are apparent in the cell lines after inhibition with 1000 nM Palbociclib for 3 days. U-CH 1-6 (A) and U-CH 7-12 (A).
Supplementary Figure 7 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Proliferation assay using Alamar Blue assay for U-CH2, 3, 6 and 10. Increasing concentrations of Palbociclib lead to an increase of growth inhibition of chordoma cells.
Supplementary Figure 6 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Immunocytology of U-CH1 control vs inhibited cells with 1000 nM Palbociclib for 3 days. Ki-67 decreases from 20% down to <1% and expression of pRb decreases in as shown by reduction of positive nucleus count and staining intensity.
Supplementary Figure 4C from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Expression data of mRNA as shown by box plot graphs for brachyury (A), collagen 2A1 (B) and CD24 (C).
Supplementary Figure 4A, B from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Expression data of mRNA as shown by box plot graphs for brachyury (A), collagen 2A1 (B) and CD24 (C).
Supplementary Figure S2 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Authors: Priolo Carmen , Pyne Saumyadipta , Rose Joshua , Regan Erzsébet Ravasz , Zadra Giorgia , Photopoulos Cornelia , Cacciatore Stefano , Schultz Denise , Scaglia Natalia , McDunn Jonathan , De Marzo Angelo M. , Loda Massimo
Published: April 2023

Concentration of glycolysis metabolites (A) in genetically engineered RWPE-1 cells and mice, and human prostate tissue samples. Controls (RWPE-EV, WT mice and normal prostate samples) are represented in blue, phosphoAKT1-high samples in orange and MYC-high samples are in green. (B) Diagram and concentration of metabolites of the glycine/sarcosine pathway in WT (blue), MPAKT (orange) and Lo-MYC (green) mice. One-way analysis of variance (ANOVA) followed by Tukey's Multiple Comparison Test was performed using post-normalization metabolite quantities.
Supplementary Figure S1 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Authors: Priolo Carmen , Pyne Saumyadipta , Rose Joshua , Regan Erzsébet Ravasz , Zadra Giorgia , Photopoulos Cornelia , Cacciatore Stefano , Schultz Denise , Scaglia Natalia , McDunn Jonathan , De Marzo Angelo M. , Loda Massimo
Published: April 2023

(A) Box plots of phosphoAKT1 or MYC levels in low- or high-Gleason prostate tumors. (B) Representative cases of phosphoAKT1-high/MYC-low (orange box), phosphoAKT1-high/MYC-high (dark grey box), phosphoAKT1-low/MYC-high (green box) and phosphoAKT1-low/MYC-low (light grey box) prostate tumors and matched normal samples are shown with immunoblots for phosphoAKT1 and MYC. (C) Schematic illustration of the methodology.
Supplementary Dataset 4 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Authors: Priolo Carmen , Pyne Saumyadipta , Rose Joshua , Regan Erzsébet Ravasz , Zadra Giorgia , Photopoulos Cornelia , Cacciatore Stefano , Schultz Denise , Scaglia Natalia , McDunn Jonathan , De Marzo Angelo M. , Loda Massimo
Published: April 2023

Metabolomics dataset
Supplemental Table S1 from Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer
Authors: Cunha Sara I. , Bocci Matteo , Lövrot John , Eleftheriou Nikolas , Roswall Pernilla , Cordero Eugenia , Lindström Linda , Bartoschek Michael , Haller B. Kristian , Pearsall R. Scott , Mulivor Aaron W. , Kumar Ravindra , Larsson Christer , Bergh Jonas , Pietras Kristian
Published: April 2023

Endothelial genes co-expressed with ACVRL1 in the clinical data sets.
Supplemental Figure S2 from Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer
Authors: Cunha Sara I. , Bocci Matteo , Lövrot John , Eleftheriou Nikolas , Roswall Pernilla , Cordero Eugenia , Lindström Linda , Bartoschek Michael , Haller B. Kristian , Pearsall R. Scott , Mulivor Aaron W. , Kumar Ravindra , Larsson Christer , Bergh Jonas , Pietras Kristian
Published: April 2023

The therapeutic benefit of ALK1-Fc is due to on-target effects on ALK1 signaling.
Supplementary Figure S5 from Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin
Authors: Marchiq Ibtissam , Le Floch Renaud , Roux Danièle , Simon Marie-Pierre , Pouyssegur Jacques
Published: April 2023

Figure S5: BSG/MCT complex knockout sensitizes cells to phenformin, a mitochondrial complex I inhibitor.
Supplementary Figure S3 from Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin
Authors: Marchiq Ibtissam , Le Floch Renaud , Roux Danièle , Simon Marie-Pierre , Pouyssegur Jacques
Published: April 2023

Figure S3: Effect of BSG/MCTs complex disruption on BSG/MCTS mRNA expression and HIF-1 stability.
Supplementary Table S1 from IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden
Authors: van der Zee Marten , Sacchetti Andrea , Cansoy Medine , Joosten Rosalie , Teeuwssen Miriam , Heijmans-Antonissen Claudia , Ewing-Graham Patricia C. , Burger Curt W. , Blok Leen J. , Fodde Riccardo
Published: April 2023

Supplementary Table S1. Clonogenicity analysis of sorted endometrial cancer cells.
Supplementary Figure 2 from Manic Fringe Promotes a Claudin-Low Breast Cancer Phenotype through Notch-Mediated PIK3CG Induction
Authors: Zhang Shubing , Chung Wen-Cheng , Wu Guanming , Egan Sean E. , Miele Lucio , Xu Keli
Published: April 2023

Supplementary Figure 2. Knockdown of Mfng has no effect on proliferation of MDA-MB231 or C0321 cells
Supplementary Methods and Figure Legends from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Authors: Klingler Stefan , Guo Baofeng , Yao Jun , Yan Haiyan , Zhang Ling , Vaseva Angelina V. , Chen Sida , Canoll Peter , Horner James W. , Wang Y. Alan , Paik Ji-Hye , Ying Haoqiang , Zheng Hongwu
Published: April 2023

Supplementary Methods and Figure Legends
Supplementary Movie 3 from STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious
Authors: Maycotte Paola , Gearheart Christy M. , Barnard Rebecca , Aryal Suraj , Mulcahy Levy Jean M. , Fosmire Susan P. , Hansen Ryan J. , Morgan Michael J. , Porter Christopher C. , Gustafson Daniel L. , Thorburn Andrew
Published: April 2023

MOV file - 3729K, MDAMB231 cells were transduced with a Non-silencing shRNA and imaged for 48h.
Supplementary Movie 1 from STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious
Authors: Maycotte Paola , Gearheart Christy M. , Barnard Rebecca , Aryal Suraj , Mulcahy Levy Jean M. , Fosmire Susan P. , Hansen Ryan J. , Morgan Michael J. , Porter Christopher C. , Gustafson Daniel L. , Thorburn Andrew
Published: April 2023

MOV file - 3141K, MCF7 cells were transduced with a Non-silencing shRNA and imaged for 48h.
Supplementary Table S1 from Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
Authors: Sadok Amine , McCarthy Afshan , Caldwell John , Collins Ian , Garrett Michelle D. , Yeo Maggie , Hooper Steven , Sahai Erik , Kuemper Sandra , Mardakheh Faraz K. , Marshall Christopher J.
Published: April 2023

Supplementary Table S1. Activity profiles of the 3 compounds against 140 kinases.
Supplementary Figure S3 from ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway
Authors: Li Xiao-Qing , Du Xin , Li Dong-Mei , Kong Peng-Zhou , Sun Yan , Liu Pei-Fang , Wang Qing-Shan , Feng Yu-Mei
Published: April 2023

Figure S3. ITGBL1 is an activator of the TGF-β signaling pathway and a mediator of Runx2 in regulating expression of bone metastasis-related genes.
supplementary methods and figure legends from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

supplementary methods and figure legends
supplementary Table 8 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

Correlation between the clinicopathologic features and expression of PAFR in gastric cancer
Supplementary Dataset 4 from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Authors: Sun Yuting , Bell Jessica L. , Carter Daniel , Gherardi Samuele , Poulos Rebecca C. , Milazzo Giorgio , Wong Jason W.H. , Al-Awar Rima , Tee Andrew E. , Liu Pei Y. , Liu Bing , Atmadibrata Bernard , Wong Matthew , Trahair Toby , Zhao Quan , Shohet Jason M. , Haupt Ygal , Schulte Johannes H. , Brown Peter J. , Arrowsmith Cheryl H. , Vedadi Masoud , MacKenzie Karen L. , Hüttelmaier Stefan , Perini Giovanni , Marshall Glenn M. , Braithwaite Antony , Liu Tao
Published: April 2023

List of N-Myc-binding gene promoters at which H3K4me3 was not reduced by WDR5 siRNA.
supplementary Table 2 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

Correlation between the clinicopathologic features and expression of PAFR in NSCLC
Supplementary Figure 2 from TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity
Authors: Vanpouille-Box Claire , Diamond Julie M. , Pilones Karsten A. , Zavadil Jiri , Babb James S. , Formenti Silvia C. , Barcellos-Hoff Mary Helen , Demaria Sandra
Published: April 2023

Figure 2S: Local radiotherapy combined with TGFÃŽÂ² blockade induces immune-related canonical pathways.
Supplemental Methods, Figure Legends, Tables 1 - 5 from EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1
Authors: Chang Yung-Sheng , Chen Wei-Yu , Yin Juan Juan , Sheppard-Tillman Heather , Huang Jiaoti , Liu Yen-Nien
Published: April 2023

Table S1. Positions of AT-rich minimal consensus sequences (ATRSs). Table S2. Primer sequences of the 3'UTR and promoter reporter constructs. Table S3. Primer sequences for the qRT-PCR. Table S4. Antibody information for Western blotting. Table S5. Antibody information and primer sequences of the ChIP assay.
Supplementary Table S4 from B-Raf Inhibitors Induce Epithelial Differentiation in BRAF-Mutant Colorectal Cancer Cells
Authors: Herr Ricarda , Köhler Martin , Andrlová Hana , Weinberg Florian , Möller Yvonne , Halbach Sebastian , Lutz Lisa , Mastroianni Justin , Klose Martin , Bittermann Nicola , Kowar Silke , Zeiser Robert , Olayioye Monilola A. , Lassmann Silke , Busch Hauke , Boerries Melanie , Brummer Tilman
Published: April 2023

Supplementary Table S4. Loss of oncogenic B-Raf signaling induces transcripts associated with intestinal differentiation.
Fig. S12 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

PAFR expression was associated with pSrc, pJAK2, pStat3, or IL-6 expression in 90 primary human NSCLC specimens.
Supplementary Table S3 from B-Raf Inhibitors Induce Epithelial Differentiation in BRAF-Mutant Colorectal Cancer Cells
Authors: Herr Ricarda , Köhler Martin , Andrlová Hana , Weinberg Florian , Möller Yvonne , Halbach Sebastian , Lutz Lisa , Mastroianni Justin , Klose Martin , Bittermann Nicola , Kowar Silke , Zeiser Robert , Olayioye Monilola A. , Lassmann Silke , Busch Hauke , Boerries Melanie , Brummer Tilman
Published: April 2023

Supplementary Table S3. Excel file containing the GO-term analysis with all differentially expressed genes.
Supplementary Table S1 from IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
Authors: Izquierdo-Garcia Jose L. , Viswanath Pavithra , Eriksson Pia , Cai Larry , Radoul Marina , Chaumeil Myriam M. , Blough Michael , Luchman H. Artee , Weiss Samuel , Cairncross J. Gregory , Phillips Joanna J. , Pieper Russell O. , Ronen Sabrina M.
Published: April 2023

Comparison of PDH activity in the various models used in this study.
Supplementary Table. S8 from Development of Lung Adenocarcinomas with Exclusive Dependence on Oncogene Fusions
Authors: Saito Motonobu , Shimada Yoko , Shiraishi Kouya , Sakamoto Hiromi , Tsuta Koji , Totsuka Hirohiko , Chiku Suenori , Ichikawa Hitoshi , Kato Mamoru , Watanabe Shun-ichi , Yoshida Teruhiko , Yokota Jun , Kohno Takashi
Published: April 2023

Supplementary Table. S8. Gene mutations detected by deep resequencing in 29 pan-negative cases
Supplementary Table. S6 from Development of Lung Adenocarcinomas with Exclusive Dependence on Oncogene Fusions
Authors: Saito Motonobu , Shimada Yoko , Shiraishi Kouya , Sakamoto Hiromi , Tsuta Koji , Totsuka Hirohiko , Chiku Suenori , Ichikawa Hitoshi , Kato Mamoru , Watanabe Shun-ichi , Yoshida Teruhiko , Yokota Jun , Kohno Takashi
Published: April 2023

Supplementary Table. S6. Comparison of gene mutations between the study cohort and the TCGA cohort
Supplementary Table. S3 from Development of Lung Adenocarcinomas with Exclusive Dependence on Oncogene Fusions
Authors: Saito Motonobu , Shimada Yoko , Shiraishi Kouya , Sakamoto Hiromi , Tsuta Koji , Totsuka Hirohiko , Chiku Suenori , Ichikawa Hitoshi , Kato Mamoru , Watanabe Shun-ichi , Yoshida Teruhiko , Yokota Jun , Kohno Takashi
Published: April 2023

Supplementary Table. S3. Top 50 significantly mutated genes deduced by MutSigCV analysis
Figure S4 from Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer
Authors: Qu Zhaoxia , Sun Fan , Zhou Jingjiao , Li Liwen , Shapiro Steven D. , Xiao Gutian
Published: April 2023

In vitro apoptosis suppression and cytotoxicity increase of CD8 T cells by IL-6.
Supplementary Fig. S6 from Development of Lung Adenocarcinomas with Exclusive Dependence on Oncogene Fusions
Authors: Saito Motonobu , Shimada Yoko , Shiraishi Kouya , Sakamoto Hiromi , Tsuta Koji , Totsuka Hirohiko , Chiku Suenori , Ichikawa Hitoshi , Kato Mamoru , Watanabe Shun-ichi , Yoshida Teruhiko , Yokota Jun , Kohno Takashi
Published: April 2023

Supplementary Fig. S6. Mutation spectra and frequencies by driver aberration and smoking status
Supplementary Table and Figure Legends from Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival
Authors: Schliekelman Mark J. , Taguchi Ayumu , Zhu Jun , Dai Xudong , Rodriguez Jaime , Celiktas Muge , Zhang Qing , Chin Alice , Wong Chee-Hong , Wang Hong , McFerrin Lisa , Selamat Suhaida A. , Yang Chenchen , Kroh Evan M. , Garg Kavita S. , Behrens Carmen , Gazdar Adi F. , Laird-Offringa Ite A. , Tewari Muneesh , Wistuba Ignacio I. , Thiery Jean P. , Hanash Samir M.
Published: April 2023

Legends for Supplementary Tables S1-S5 and Supplementary Figures S1-S2.
Supplemental Table S3 from PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways
Authors: Kaistha Brajesh P. , Lorenz Holger , Schmidt Harald , Sipos Bence , Pawlak Michael , Gierke Berthold , Kreider Ramona , Lankat-Buttgereit Brigitte , Sauer Melanie , Fiedler Lisa , Krattenmacher Anja , Geisel Bettina , Kraus Johann M. , Frese Kristopher K. , Kelkenberg Sabine , Giese Nathalia A. , Kestler Hans A. , Gress Thomas M. , Buchholz Malte
Published: April 2023

Results of Pathway Enrichment Analysis.
Supplemental Table S1 from PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways
Authors: Kaistha Brajesh P. , Lorenz Holger , Schmidt Harald , Sipos Bence , Pawlak Michael , Gierke Berthold , Kreider Ramona , Lankat-Buttgereit Brigitte , Sauer Melanie , Fiedler Lisa , Krattenmacher Anja , Geisel Bettina , Kraus Johann M. , Frese Kristopher K. , Kelkenberg Sabine , Giese Nathalia A. , Kestler Hans A. , Gress Thomas M. , Buchholz Malte
Published: April 2023

Summary of assays and effects from RPPA analyses.
Supplementary Methods and References from Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival
Authors: Schliekelman Mark J. , Taguchi Ayumu , Zhu Jun , Dai Xudong , Rodriguez Jaime , Celiktas Muge , Zhang Qing , Chin Alice , Wong Chee-Hong , Wang Hong , McFerrin Lisa , Selamat Suhaida A. , Yang Chenchen , Kroh Evan M. , Garg Kavita S. , Behrens Carmen , Gazdar Adi F. , Laird-Offringa Ite A. , Tewari Muneesh , Wistuba Ignacio I. , Thiery Jean P. , Hanash Samir M.
Published: April 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure S5 from Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival
Authors: Langenkamp Elise , Zhang Lei , Lugano Roberta , Huang Hua , Elhassan Tamador Elsir Abu , Georganaki Maria , Bazzar Wesam , Lööf Johan , Trendelenburg George , Essand Magnus , Pontén Fredrik , Smits Anja , Dimberg Anna
Published: April 2023

Endothelial polarity in GL261 and T241 vessels.
Supplementary Methods from SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm
Authors: Hamblett Kevin J. , Jacob Allison P. , Gurgel Jesse L. , Tometsko Mark E. , Rock Brooke M. , Patel Sonal K. , Milburn Robert R. , Siu Sophia , Ragan Seamus P. , Rock Dan A. , Borths Christopher J. , O'Neill Jason W. , Chang Wesley S. , Weidner Margaret F. , Bio Matthew M. , Quon Kim C. , Fanslow William C.
Published: April 2023

Description of additional methods and procedures used in the study.
Figure S4 from Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Authors: Kothari Anisha , Hittelman Walter N. , Chambers Timothy C.
Published: April 2023

Supplementary Figure 4
Supplementary Table S6 from CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer
Authors: Yoshida Taku , Kim Jee Hyun , Carver Kristopher , Su Ying , Weremowicz Stanislawa , Mulvey Laura , Yamamoto Shoji , Brennan Cameron , Mei Shenglin , Long Henry , Yao Jun , Polyak Kornelia
Published: April 2023

Supplementary Table S6. List of top 275 genes with changes in splice variants following downregulation of CLK2.
Supplemental Figure and Table Legends from Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53
Authors: Ng Jessica M.Y. , Martinez Daniel , Marsh Eric D. , Zhang Zhe , Rappaport Eric , Santi Mariarita , Curran Tom
Published: April 2023

Legends for Supplemental Figures S1-S5 and Supplemental Table S1.
Supplemental Figure S5 from Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53
Authors: Ng Jessica M.Y. , Martinez Daniel , Marsh Eric D. , Zhang Zhe , Rappaport Eric , Santi Mariarita , Curran Tom
Published: April 2023

Gene Set Enrichment Analysis shows close resemblance between human and mouse brain tumors.
Table S3 from Whole-Exome Sequencing Reveals Frequent Genetic Alterations in BAP1, NF2, CDKN2A, and CUL1 in Malignant Pleural Mesothelioma
Authors: Guo Guangwu , Chmielecki Juliann , Goparaju Chandra , Heguy Adriana , Dolgalev Igor , Carbone Michele , Seepo Sara , Meyerson Matthew , Pass Harvey I.
Published: April 2023

Table S3. A list of all somatic mutations detected in 22 MPMs
Supplementary Figure S2 from SND1 Acts Downstream of TGFβ1 and Upstream of Smurf1 to Promote Breast Cancer Metastasis
Authors: Yu Lin , Liu Xin , Cui Kang , Di Yanbo , Xin Lingbiao , Sun Xiaoming , Zhang Wei , Yang Xi , Wei Minxin , Yao Zhi , Yang Jie
Published: April 2023

Supplementary Figure S2. The collection of all q-RT-PCR results by using β-actin as reference gene.
Table S2 from Disseminated Tumor Cells Persist in the Bone Marrow of Breast Cancer Patients through Sustained Activation of the Unfolded Protein Response
Authors: Bartkowiak Kai , Kwiatkowski Marcel , Buck Friedrich , Gorges Tobias M. , Nilse Lars , Assmann Volker , Andreas Antje , Müller Volkmar , Wikman Harriet , Riethdorf Sabine , Schlüter Hartmut , Pantel Klaus
Published: April 2023

SILAC identification details for BC-M1 and MDA-MB-468
Figure S3 from Disseminated Tumor Cells Persist in the Bone Marrow of Breast Cancer Patients through Sustained Activation of the Unfolded Protein Response
Authors: Bartkowiak Kai , Kwiatkowski Marcel , Buck Friedrich , Gorges Tobias M. , Nilse Lars , Assmann Volker , Andreas Antje , Müller Volkmar , Wikman Harriet , Riethdorf Sabine , Schlüter Hartmut , Pantel Klaus
Published: April 2023

Quantitative Western Blot analysis; detection of NOS2 and G6PD
Figure S2 from Disseminated Tumor Cells Persist in the Bone Marrow of Breast Cancer Patients through Sustained Activation of the Unfolded Protein Response
Authors: Bartkowiak Kai , Kwiatkowski Marcel , Buck Friedrich , Gorges Tobias M. , Nilse Lars , Assmann Volker , Andreas Antje , Müller Volkmar , Wikman Harriet , Riethdorf Sabine , Schlüter Hartmut , Pantel Klaus
Published: April 2023

Quality control of the SILAC experiment
Supplementary Figure S13 from Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy: A Report from the BELOB Trial
Authors: Erdem-Eraslan Lale , van den Bent Martin J. , Hoogstrate Youri , Naz-Khan Hina , Stubbs Andrew , van der Spek Peter , Böttcher René , Gao Ya , de Wit Maurice , Taal Walter , Oosterkamp Hendrika M. , Walenkamp Annemiek , Beerepoot Laurens V. , Hanse Monique C.J. , Buter Jan , Honkoop Aafke H. , van der Holt Bronno , Vernhout René M. , Smitt Peter A.E. Sillevis , Kros Johan M. , French Pim J.
Published: April 2023

Example of genomic breakpoints identified by RNA sequencing.
Supplementary Figures S1-S6 from Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo
Authors: Rao Shreyas S. , Bushnell Grace G. , Azarin Samira M. , Spicer Graham , Aguado Brian A. , Stoehr Jenna R. , Jiang Eric J. , Backman Vadim , Shea Lonnie D. , Jeruss Jacqueline S.
Published: April 2023

Micro-porous PCL scaffolds persist and maintain a space for extended times in vivo (S1); Host response following implantation of micro-porous PCL scaffolds in the dorsal subcutaneous space of an NSG mouse in vivo (S2); Dynamics of immune cell populations in the spleen of BALB/c mice with a PCL scaffold implant at day 0, 5, 10, and 15 post tumor inoculation (S3); Micro-porous PCL scaffolds enable recruitment of human MDA-MD-231BR cells in a chronic model of scaffold implantation (S4); Micro-porous PCL scaffolds do not significantly improve survival in a post-surgical model of breast cancer metastasis with day 6 post tumor inoculation resection (S5); Anti-Gr-1 depletion significantly reduces the presence of CD11b+Gr-1hiLy6C- MDSCs in the spleen primary tumor and scaffold (S6).
Supplementary Figure S6 from ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis
Authors: Rodriguez Calleja Lidia , Jacques Camille , Lamoureux François , Baud'huin Marc , Tellez Gabriel Marta , Quillard Thibaut , Sahay Debashish , Perrot Pierre , Amiaud Jerome , Charrier Celine , Brion Regis , Lecanda Fernando , Verrecchia Franck , Heymann Dominique , Ellisen Leif W. , Ory Benjamin
Published: April 2023

miR-527 and miR-665 regulate metastasis dissemination in vivo.
Supplemental Meterials and Methods from EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1
Authors: Zhang Ying , Wang Shuling , Li Lingsong
Published: April 2023

Supplemental Meterials and Methods
Supplemental Figure Legends from BAFF and APRIL from Activin A–Treated Dendritic Cells Upregulate the Antitumor Efficacy of Dendritic Cells In Vivo
Authors: Shurin Michael R. , Ma Yang , Keskinov Anton A. , Zhao Ruijing , Lokshin Anna , Agassandian Marianna , Shurin Galina V.
Published: April 2023

Supplemental Figure Legends
Supplemental Figure 3 from BAFF and APRIL from Activin A–Treated Dendritic Cells Upregulate the Antitumor Efficacy of Dendritic Cells In Vivo
Authors: Shurin Michael R. , Ma Yang , Keskinov Anton A. , Zhao Ruijing , Lokshin Anna , Agassandian Marianna , Shurin Galina V.
Published: April 2023

Recombinant APRIL (B), but not recombinant BAFF (A), stimulates proliferation of T-cells.
Table S1 from Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas
Authors: Droog Marjolein , Nevedomskaya Ekaterina , Kim Yongsoo , Severson Tesa , Flach Koen D. , Opdam Mark , Schuurman Karianne , Gradowska Patrycja , Hauptmann Michael , Dackus Gwen , Hollema Harry , Mourits Marian J. , Nederlof Petra , van Boven Hester , Linn Sabine C. , Wessels Lodewyk , van Leeuwen Flora E. , Zwart Wilbert
Published: April 2023

Clinicopathological parameters of patient samples in the TAMARISK-study. MC-UC = interval between breast cancer and endometrial cancer.
Figure S3 from Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas
Authors: Droog Marjolein , Nevedomskaya Ekaterina , Kim Yongsoo , Severson Tesa , Flach Koen D. , Opdam Mark , Schuurman Karianne , Gradowska Patrycja , Hauptmann Michael , Dackus Gwen , Hollema Harry , Mourits Marian J. , Nederlof Petra , van Boven Hester , Linn Sabine C. , Wessels Lodewyk , van Leeuwen Flora E. , Zwart Wilbert
Published: April 2023

Biological replicates of ChIP-seq analyses for ERalpha (A), RNA Polymerase II (B), H3K27Ac (C) and FOXA1 (D).
Supplementary Figure S7 from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Authors: Guo Yabin , Updegraff Barrett L. , Park Sunho , Durakoglugil Deniz , Cruz Victoria H. , Maddux Sarah , Hwang Tae Hyun , O'Donnell Kathryn A.
Published: April 2023

Expression analysis of CIS genes with SB insertions in mutagenized Ba/F3 pools.
Supplementary figure 1 from p73 and IGF1R Regulate Emergence of Aggressive Cancer Stem–like Features via miR-885-5p Control
Authors: Meier Claudia , Hardtstock Philip , Joost Sophie , Alla Vijay , Pützer Brigitte M.
Published: April 2023

DNp73 regulates stemness
Supplementary Figures S1-S8 from Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α
Authors: Schönenberger Désirée , Harlander Sabine , Rajski Michal , Jacobs Robert A. , Lundby Anne-Kristine , Adlesic Mojca , Hejhal Tomas , Wild Peter J. , Lundby Carsten , Frew Ian J.
Published: April 2023

Additional data related to histological analyses, establishing renal epithelial cell culture, analyses of microarray data and further analyses of Vhl/Trp53-, Vhl/Trp53/Hif1a- and Vhl/Trp53/Hif2a-deficient mice,
Supplementary Figure Legends from AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation
Authors: Li Chia-Wei , Xia Weiya , Lim Seung-Oe , Hsu Jennifer L. , Huo Longfei , Wu Yun , Li Long-Yuan , Lai Chien-Chen , Chang Shih-Shin , Hsu Yi-Hsin , Sun Hui-Lung , Kim Jongchan , Yamaguchi Hirohito , Lee Dung-Fang , Wang Hongmei , Wang Yan , Chou Chao-Kai , Hsu Jung-Mao , Lai Yun-Ju , LaBaff Adam M. , Ding Qingqing , Ko How-Wen , Tsai Fuu-Jen , Tsai Chang-Hai , Hortobagyi Gabriel N. , Hung Mien-Chie
Published: April 2023

Supplementary Figure Legends
Supplementary Table 6 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: April 2023

Supplementary Table 6. Colon tumor pTyr and protein expression groups
Figure S7: Time-course YAP cytoplasmic-nuclear shuttling upon RASSF1A depletion. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: April 2023

Representative images are shown for YAP localization changes, by immunofluorescence and confocal microscopy. HBEC-3 cells were transfected by inactive siNeg (upper lane), siRASS1A, siYAP or siRASSF1A plus siYAP (lower lane) and monitored 12, 24, 36 and 48h after transfection for YAP. The cells were stained by Yap primary antibody (Green) followed by Alexa488 conjugated secondary antibody, along with DAPI for DNA (Blue).
Supplemental Methods from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Authors: Giraud Julie , Failla Laura M. , Pascussi Jean-Marc , Lagerqvist Ebba L. , Ollier Jérémy , Finetti Pascal , Bertucci François , Ya Chu , Gasmi Imène , Bourgaux Jean-François , Prudhomme Michel , Mazard Thibault , Ait-Arsa Imade , Houhou Leila , Birnbaum Daniel , Pélegrin André , Vincent Charles , Ryall James G. , Joubert Dominique , Pannequin Julie , Hollande Frédéric
Published: April 2023

Description of additional methods and procedures used in the study.
Figure S3: Expression of siRNA-resistant RASSF1A rescues EMT phenotype induced by RASSF1A depletion. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: April 2023

HBEC-3 cells were transiently transfected with siNeg or siRASSF1A in association with either pcDNA3-RASSF1A or pcDNA3-RASSF1C. The experiences were performed 48 hours after transfection. A. Representative images for RASSF1A expression changes by immunofluorescence and confocal microscopy. RASSF1A primary antibody (Red) followed by Alexa 555 conjugated secondary antibody along with DAPI for DNA (Blue) was used as a control along with DAPI for DNA (Blue). Scale bar represents 50 µm. B. Representative blots for quantification of Twist and Vimentin proteins levels by western blotting in HBEC-3 cells. Actin was used as an internal control. (n=2) C. The migration speed (µm/h) of transfected HBEC-3 cells was determined by wound healing assay on collagen I & IV. Mitomycin C (1 µg/ml) was added to medium 12h before scratch in order to limit cell proliferation. D. Representative images for nuclear localization of Yap in HBEC-3 cell by immunofluorescence and confocal microscopy. The cells stained by Yap primary antibody (Green) followed by Alexa488 conjugated secondary antibody, along with DAPI for DNA (Blue). Scale bar represents 50 µm. For all of the histograms, error bars indicate the standard error of the mean (SEM) of at least three independent experiments. *p<0.05, **p<0.01 and ***p<0.001, using an ANOVA test followed by Dunnett's test.
Supplemental Figure S3 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Authors: Giraud Julie , Failla Laura M. , Pascussi Jean-Marc , Lagerqvist Ebba L. , Ollier Jérémy , Finetti Pascal , Bertucci François , Ya Chu , Gasmi Imène , Bourgaux Jean-François , Prudhomme Michel , Mazard Thibault , Ait-Arsa Imade , Houhou Leila , Birnbaum Daniel , Pélegrin André , Vincent Charles , Ryall James G. , Joubert Dominique , Pannequin Julie , Hollande Frédéric
Published: April 2023

Progastrin regulates the self-renewal of ALDHhigh colorectal CSCs.
Supplemental Table 1 from M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers
Authors: Ohashi Yoshimi , Okamura Mutsumi , Hirosawa Asaka , Tamaki Naomi , Akatsuka Akinobu , Wu Kuo-Ming , Choi Hyeong-Wook , Yoshimatsu Kentaro , Shiina Isamu , Yamori Takao , Dan Shingo
Published: April 2023

The antibodies used in this study.
Supplementary Figure 5 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: April 2023

Treatment with IT-901 for 14 days does not alter lymphocyte numbers.
Supplementary Figure 11 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: April 2023

IT-901 inhibits growth of human DLBCL cell lines.
Supplementary Tables and Figures from IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis
Authors: Brooks Gavin D. , McLeod Louise , Alhayyani Sultan , Miller Alistair , Russell Prudence A. , Ferlin Walter , Rose-John Stefan , Ruwanpura Saleela , Jenkins Brendan J.
Published: April 2023

Table S1: Clinicopathological features of LAC patients and control LAC-free individuals. Table S2: Primers used in qPCR assays. Figure S1: Augmented Kras-induced lung adenocarcinoma in gp130F/F mice is not associated with enhanced inflammation. Figure S2: Gene expression analyses during KrasG12D-induced lung carcinogenesis. Figure S3: IL-6 deficiency in the lungs of gp130F/F:KrasG12D mice suppresses cellular apoptosis and inflammation. Figure S4: Nuclear expression of tyrosine-phosphorylated (activated) STAT3 in the epithelial lesions in the lungs of F/F:KrasG12D mice. Figure S5: Reduced STAT3 activation in the lungs of gp130F/F mice upon genetic ablation of IL-6 trans-signaling with sgp130Fc. Figure S6: Blockade of IL-6 trans-signaling with mAbs in KrasG12D mice reduces lung carcinogenesis. Figure S7: Blockade of IL-6 trans-signaling suppresses the growth of human LAC cell lines.
Supplementary Table S3 from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: April 2023

Intensities of all Class I phosphosites p(STY) light (PDX) and heavy (SILAC) identified in 16 PDXs
Supplementary Table S2 from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: April 2023

Class I phosphotyrosine (pY) sites of the "Tyrosine Kinases" enriched either in T-ALL (ALL-8, ALL-31) and B-ALL (ALL-17, ALL-19)
Supplementary Table S1 from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: April 2023

Class I phosphosites (pSTY) identified in T-ALL (ALL-8, ALL-31) and B-ALL (ALL-17, ALL-19)
Supplemental Figure Legends from Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling
Authors: Yeo Syn Kok , Wen Jian , Chen Song , Guan Jun-Lin
Published: April 2023

Legend for Supplemental Figures S1-S4.
Supplementary figure 1 from Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma
Authors: Delgado-Calle Jesus , Anderson Judith , Cregor Meloney D. , Hiasa Masahiro , Chirgwin John M. , Carlesso Nadia , Yoneda Toshiyuki , Mohammad Khalid S. , Plotkin Lilian I. , Roodman G. David , Bellido Teresita
Published: April 2023

Supplementary figure 1. MM cells induce apoptosis and activate Notch signaling in osteocytes.
Supplementary figure 2 from Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
Authors: Rodriguez-Ruiz María E. , Rodriguez Inmaculada , Garasa Saray , Barbes Benigno , Solorzano Jose Luis , Perez-Gracia Jose Luis , Labiano Sara , Sanmamed Miguel F. , Azpilikueta Arantza , Bolaños Elixabet , Sanchez-Paulete Alfonso R. , Aznar M. Angela , Rouzaut Ana , Schalper Kurt A. , Jure-Kunkel Maria , Melero Ignacio
Published: April 2023

4T1-derived spontaneous lung metastases
Supplementary Figure 2 from Eritoran Suppresses Colon Cancer by Altering a Functional Balance in Toll-like Receptors That Bind Lipopolysaccharide
Authors: Kuo Wei-Ting , Lee Tsung-Chun , Yu Linda Chia-Hui
Published: April 2023

Knockdown efficiency of LPS receptor subunits and PKCζ in primary mouse colonic tumor spheroids and human adenocarcinoma cell lines.
Supplementary Table S1 from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma
Authors: Vatolin Sergei , Phillips James G. , Jha Babal K. , Govindgari Shravya , Hu Jennifer , Grabowski Dale , Parker Yvonne , Lindner Daniel J. , Zhong Fei , Distelhorst Clark W. , Smith Mitchell R. , Cotta Claudiu , Xu Yan , Chilakala Sujatha , Kuang Rebecca R. , Tall Samantha , Reu Frederic J.
Published: April 2023

Small molecule screening data
Supplementary Figures S1-S14 from TG2 and NF-κB Signaling Coordinates the Survival of Mantle Cell Lymphoma Cells via IL6-Mediated Autophagy
Authors: Zhang Han , Chen Zheng , Miranda Roberto N. , Medeiros L. Jeffrey , McCarty Nami
Published: April 2023

TG2 exon 1 was selected for a site for sgRNA-mediated silencing via a LentiCRISPR system (S1); Apoptotic evaluation of SP53 and Jeko cells with TG2KO using FACS analysis (S2); IL-8 mRNA levels were measured by qRT-PCR in MCL cells with TG2KO or TG2OE. The controls were mock-transfected cells (S3); TG2 contributes to chemotherapy resistance in MCL (S4); Jeko MCL cells with GFP+ p50KD or p65KD were imaged under microscopy (S5); IL-6 addition increases MCL cell viability against chemotherapeutic drugs (S6); TG2 and IL-6 mediates the increased colony-formation ability of MCL cells in MethoCult medium (S7); ATG5 exon 2 was selected for a site for sgRNA mediated silencing via LentiCRISPR system (S8); ATG5KO cells show reduced proliferation rate and increased apoptosis (S9); TG2 signaling regulates autophagy (S10); Upregulated autophagy is responsible for the chemotherapy resistance, which caused by TG2 overexpression in MCL (S11); TG2 overexpression leads to resistance to mTOR inhibitor in MCL (S12); The detection of mRNA levels of IL-6, IL-6 receptor, and IL-6 signal transducer (S13); CD19+ B cells were isolated from apheresis blood / bone marrow of the MCL patients or peripheral blood from healthy donors (S14).