bluuebunny/crossref_metadata_2025 huggingface dataset:
Escalas para Mensurar Inovação:
Authors: Costa Esdras da Silva , Crespo dos Reis Neto Aline
Published: May 2022

Esta pesquisa objetiva verificar e analisar as escalas utilizadas para mensurar a inovação no contexto empresarial. Enquanto metodologia trata-se de uma pesquisa documental realizada a partir de documentos retrospectos e contemporâneos (escalas de inovação) cientificamente validadas e respaldadas em estudos publicados na área de Administração, Ciências Contábeis e Turismo – ACT. A fase de levantamento dos artigos foi conduzida por uma revisão bibliométrica, com base em artigos revisados por pares, sendo a busca realizada na Plataforma Capes a partir da seleção de textos relacionados com a criação de escalas e instrumentos para mensurar inovação em Micro e Pequenas Empresas entre os períodos de 2000 a 2016. Os resultados da pesquisa identificaram que em alguns modelos as escalas de inovação contemplam apenas a mensuração de inovações em produtos e serviços, contudo em um ambiente competitivo e complexo, outros fatores inovativos devem ser explorados, tais como, inovações nos processos organizacionais e inovações nas estratégias de marketing. As escalas Redesist e o Radar da Inovação foram apontadas pela pesquisa como os modelos de escala mais robusto. Desse modo, a pesquisa corrobora com a existência de divergência no modo em que as escalas para mensurar inovação são utilizadas, em termos de conteúdo, dimensões e número de assertivas. Além de apontar uma lacuna na academia em termos e disponibilidade de ferramentas para mensurar a inovação no ambiente das Micro e Pequenas Empresas.
Percepções sobre a prática docente após a formação continuada de professores alfabetizadores, no âmbito do PNAIC
Authors: Uczak Lucia , Zucchetti Dinora Tereza , Silva Andresa Tais da
Published: May 2022

Este artigo tem como objetivo apresentar a análise da prática docente de três professoras do ciclo de alfabetização, a partir de sua participação no Curso de Formação Continuada de Professores Alfabetizadores, ofertado no âmbito do Pacto Nacional pela Alfabetização na Idade Certa (PNAIC). A metodologia da pesquisa é caracterizada pela abordagem qualitativa de cunho exploratório, constituída pelo estudo dos documentos norteadores do Pacto, observação da prática e realização de entrevistas semiestruturadas com as docentes. A base teórica sustenta-se, entre outros, em Alarcão (2001), Libâneo (2005) e Moll (2009). Nos resultados, constatamos uma mescla entre a absorção e a adequação do que foi trabalhado no Curso, apropriada à prática docente e à manutenção, ainda bastante presente, de metodologias ditas tradicionais, voltadas à exposição de informações e memorização de conteúdo, apesar dos cinco anos de formação realizada.
Experiências de portefólios digitais no ensino superior: perspetivas de professores e estudantes
Authors: Oliveira Pires Ana Luisa , Rodrigues Maria Rosário
Published: May 2022

Neste artigo, sistematizamos a experiência decorrente de um projecto de investigação e desenvolvimento, centrado no uso de portefólios digitais como estratégia de aprendizagem e de avaliação no ensino superior Português, realizado no âmbito do programa europeu Erasmus+ KA2. No contexto nacional, o projeto desenvolveu-se numa instituição de ensino superior público politécnico, tendo-se realizado um estudo piloto com dupla finalidade: compreender as perspectivas dos estudantes e dos professores face às suas experiências com portefólios digitais; e desenvolver estratégias de aprendizagem e avaliação suportadas na sua utilização. O estudo, de natureza qualitativa − investigação-ação −, mobilizou inquéritos por questionário e por entrevista. As conclusões evidenciam contributos significativos do uso de portefólios digitais pelos estudantes, como o desenvolvimento de competências digitais e de autonomia, criatividade e responsabilidade, sendo igualmente reconhecido como estratégia de aprendizagem e avaliação significativa e motivadora. Por outro lado, apesar de uma parte significativa dos docentes já possuírem experiência com portefólios e de utilizarem suportes digitais, constatou-se que os portfefólios digitais são ainda pouco explorados como estratégia de ensino-aprendizagem e de avaliação. Assim, propuseram-se um conjunto de acções com vista à melhoria da situação, criando condições para que os professores possam ser os produtores do seu próprio conhecimento e profissão.
O que é didática hoje? A didática como meio de transformação educacional e social
Authors: Imbernón Francisco
Published: May 2022

En este ensayo, el autor recupera el sentido histórico de la didáctica y lo actualiza en el contexto educativo, entendiendo que la finalidad de la didáctica bajo esta mirada es la compresión del mundo, como medio para llegar a la transformación educativa y social.
Right to early childhood education: legal, collective and individual protection
Authors: Bigarella Nádia , Gaspar Melim Ana Paula
Published: May 2022

This article analyses the right to early childhood education as legal, individual, and collective protection, through research involving systematization, analysis, and gathering of documents produced in federal scope. It was captured that such a right is connected to the basic principle of democracy − the defense of social rights prescribed by the Federal Constitution of 1988, which protects human rights and judges internal conditions for the imposition of legal guarantees that all citizens must have since birth, that is, an individual right. Early childhood education as a social right demands legal protection, the guarantee of universality, by law, so that, in practice, the access and frequency of each Brazilian child in daycare centers and pre-school facilities are fulfilled as an individual right. The solidification of the universality of early childhood education depends on the implementation of public policies, in which the procedures and main goals are established by the constitutional text.
Apresentação do dossiê: "Que didática para a escola de hoje?"
Authors: Fortunato Ivan , Araújo Osmar Hélio , Imbernón Francisco
Published: May 2022

Texto de abertura do dossiê.
THE MODERATING EFFECT OF COVID-19 ON THE RELATIONSHIP BETWEEN WORK-LIFE BALANCE AND HOTEL EMPLOYEES’ FEARS
Authors: Zaki Karam
Published: May 2022

Purpose - The hotel environment has changed dramatically during the COVID-19 and has brought many negative social consequences for employees. Among them are employee fears of COVID -19. One of the coping strategies for the consequences of COVID -19 is the Work-Life Balance (WLB). This research mainly examined the influence of WLB on employees’ fears of the threat of COVID-19. The objectives were: (1) Evaluating to what extent the hotel managers practice WLB amid COVID-19; (2) Describing the relationship between WLB and hotel employees’ fears; (3) Identifying the moderating effect of COVID-19 in the relationship between WLB and hotel employees’ fears. Design/methodology - A multiple hotel case study with an online questionnaire (n=370) complemented with seven semi-structured interviews was applied with hotel managers in Egypt. Findings - The results showed that WLB reduced hotel employees’ fear of COVID -19. COVID -19 positively moderated the relationship between WLB and employee fears. Originality - The value of this research expands our knowledge regarding the social outcomes of COVID-19 among hotel staff by offering empirical evidence of the WLB mechanism in reducing fears of COVID-19 depending on social support theory and theory of risk. Critical implications for the hotel managers are highlighted to understand the inevitability of WLB initiatives to overcome staff perceived fears.
FEELING AT HOME WHILE TRAVELING: AN ANALYSIS OF THE EXPERIENCES OF AIRBNB USERS
Authors: Gomes Pereira Santos Anna Isabelle , Costa Perinotto André Riani , Renner Rodrigues Soares Jakson , Savi Mondo Tiago
Published: May 2022

Purpose – This study analyzes the experiences of Airbnb users in the city of Fortaleza, Ceará, Brazil, through the reviews published on the platform, evealing the relevant issues experienced by users during their stays and the polarity associated with these issues. Design – Collection of 2,338 Airbnb website reviews from users who visited Fortaleza between January 2019 and October 2020, associated with 503 listings. Methodology/Approach – Data was collected between October 24 and October 28, 2020, using Parse Hub and Tableau Public for data extraction and validation, respectively. Content analysis was performed to examine the data, and NVivo was used to support the categorization and coding steps. Findings – The main analysis categories in the online reviews of Airbnb users in Fortaleza were “location”, “physical environment”, “interaction and communication with the host”, “hospitable, friendly host”, “cleanliness and organization”, “near other facilities”, “home appliances” and “view”. In turn, the least referenced categories were “experiencing the local culture”, “interaction with other guests” and “living like a place”. The analysis suggests a positivity bias in comments while negative sentiments are caused mainly by “physical environment” and “home appliances”. Originality of the research – This study identifies the themes pointed out by guests when using Airbnb, that influence the user experience.
Unravelling Transmission in Epidemiological Models and its Role in the Disease-Diversity Relationship
Authors: Toorians Marjolein  E.M. , MacPherson Ailene , Davies T. Jonathan
Published: May 2022

With the decrease of biodiversity worldwide coinciding with an increase in disease outbreaks, investigating this link is more important then ever before. This review outlines the different modelling methods commonly used for pathogen transmission in animal host systems. There are a multitude of ways a pathogen can invade and spread through a host population. The assumptions of the transmission model used to capture disease propagation determines the outbreak potential, the net reproductive success (R0). This review offers an insight into the assumptions and motivation behind common transmission mechanisms and introduces a general framework with which contact rates, the most important parameter in disease dynamics, determines the transmission method. By using a general function introduced here and this general transmission model framework, we provide a guide for future disease ecologists for how to pick the contact function that best suites their system. Additionally, this manuscript attempts to bridge the gap between mathematical disease modelling and the controversially and heavily debated disease-diversity relationship, by expanding the summarized models to multiple hosts systems and explaining the role of host diversity in disease transmission. By outlining the mechanisms of transmission into a stepwise process, this review will serve as a guide to model pathogens in multi-host systems. We will further describe these models it in the greater context of host diversity and its effect on disease outbreaks, by introducing a novel method to include host species’ evolutionary history into the framework.
Comprehensive Biotechnical System for Screening Risk-Based Diagnosis of COVID-19 and Post-COVID Syndrome
Authors: Savostyanov Vladimir , Kobelev Alexander , Kudashov Ivan
Published: May 2022

At present, there are no hardware or biochemical systems allow to assess the severity of post-COVID syndrome in vivo. The hardware of the proposed biotechnical system is based on routine transthoracic electrical impedance rheography, which makes it possible to register the frequency characteristics of the patient's bioimpedance response to controlled stress stimulation, thereby simultaneously fixing the characteristics of his productive heart, the state of the hemomicrocirculatory bed, the efficiency of the gas transport function of his blood, and also reliably assess personal reactivity and adaptive potential. Subsequent mathematical approximation of the obtained biometric data by an original neural network makes it possible to rank the results obtained and automatically generate a program of medical rehabilitation for a particular patient, depending on the severity of his post-COVID syndrome. The study results proved two reliable physiological signs confirming the presence of latent post-COVID complications: a decrease in the base impedance value for light exercise and an increase in the length of the systolic arc of the rheocardiogram.
Analysis of the Structural Protein Effects Caused by the PURA p.Phe233del Mutation Associated to Cognitive Developmental Delay Using Artificial Intelligence and Hybrid Quantum Mechanics-Molecular Mechanics Modelling
Authors: Lopez-Rivera Juan Javier , Rodríguez-Salazar Luna , Soto-Ospina Alejandro , Estrada-Serrato Carlos , Serrano David , Chaparro-Solano Henry Mauricio , Londoño Olga , Rueda Paula A. , Ardila Geraldine , Villegas-Lanau Andrés , Godoy-Corredor Marcela , Cuartas Mauricio , Vélez Jorge I. , Vidal Oscar M. , Isaza-Ruget Mario A. , Arcos-Burgos Mauricio
Published: May 2022

A whole-exome capture and next-generation sequencing applied to an 11 y/o patient with a clinical history of congenital hypotonia, generalized motor and cognitive neurodevelopmental delay, severe cognitive deficit, without any identifiable Syndromic pattern, and to her parents, disclosed a de novo heterozygous pathogenic mutation, c.697_699del p.Phe233del (rs786204835)(ACMG classification PS2, PM1, PM2, PP5), harbored in the PURA gene (MIM*600473) (5q31.3), associated to Autosomal Dominant Mental Retardation 31 (MIM # 616158). We used the significant improvement in the accuracy of protein structure prediction recently implemented in AlphaFold that incorporates novel neural network architectures and training procedures based on the evolutionary, physical, and geometric constraints of protein structures. The wild-type (WT) sequence and the mutated one, missing the Phe233, were reconstructed. The predicted local Distance Difference Test (lDDT) for the PURA WT and the PURA-Phe233del showed that the occurrence of the Phe233del affects between 220-320 amino acids. The distortion in the PURA structural confor-mation in the ~5Å surrounding area after the p.Phe233del produces a conspicuous disruption of the repeat III, where the DNA and RNA helix unwinding capability occurs. PURA Protein-DNA Docking corroborated these results in silico Analysis that showed a loss of the contact of the PURA-Phe233del III repeat domain model with the DNA. Together, i) the energetic and stereochemical, ii) the hydropathic indices and polarity surfaces, and iii) the hybrid Quantum Mechanics-Molecular Mechanics (QM-MM) analyses of the PURA molecular models demarcate at the atomic resolution the specific surrounding region affected by these mutations and paves the way for future cell-based functional analysis. To the best of our knowledge, this is the first report of a de novo mutation underpinning a PURA syndrome in a Latin American patient and highlights the importance of predicting the molecular effects in protein structure using artificial intelligence algorithms and molecular and atomic resolution stereochemical analyses.
Cervical Cancer Prevention in El Salvador: Gains to Date and Challenges for the Future
Authors: Alfaro Karla , Soler Montserrat , Maza Mauricio , Flores Mauricio , López Leticia , Rauda Juan Carlos , Chacon Andrea , Erazo Patricia , Villatoro Nora , Mumenthaler Eveline , Masch Rachel , Conzuelo Gabriel , Felix Juan C. , Cremer Miriam
Published: May 2022

Cervical cancer is preventable through vaccination, early detection, and treatment of precancerous lesions. However, global inequalities mean that the disease remains a leading cause of cancer death around the world, with over 80% of new cases and 90% of deaths occurring in low and middle-income countries (LMICs). In El Salvador, joint efforts between the Ministry of Health (MoH) and the non-profit organization Basic Health International (BHI) have been in place since 2008 with the goal of reducing the country’s disease burden. While the World Health Organization’s (WHO) call to action to eliminate cervical cancer provided worldwide momentum to implement new public health initiatives, the COVID-19 pandemic disrupted ongoing programs and jeopardized plans for the future. The purpose of this manuscript is to describe the progress that El Salvador has achieved in improving cervical cancer prevention, the impact of the pandemic on current strategies, and potential solutions that can help the country meet the WHO’s strategic targets by 2030 to accelerate the elimination of cervical cancer.
The Reactive Species Interactome - Mitochondria Axis
Authors: Chatre Laurent
Published: May 2022

From oxidative eustress and distress, to bioenergetic metabolism, and cell death, the reactive species interactome (RSI) and mitochondria are two connected metabolisms that require further investigation improving redox medicine. The step before, finding new clues needs a comprehensive discussion of the two metabolisms, and their relationship. Here, the review focuses on the RSI-mitochondria axis, from mitochondrial roles to crosstalk between mitochondria and other organelles, and the major implication of the RSI in mitochondrial roles. Specifically, the review discussed the apoptosis-necroptosis-ferroptosis death traingle, mitochondrial protein quality control system, calcium homeostasis, and mitochondrial metabolome. Through mitochondrial diseases, and mitochondrial dysfunction associated with diseases, the RSI-mitochondria axis is proposed as a brand-new perspective, including with the involvement of bacterial microbiota, on redox signaling, and redox medicine.
Reductions in Anxiety, Depression and Insomnia in Health Care Workers using a non-pharmaceutical intervention
Authors: B.S. Katherine Currie , Gupta Babu V. , Shivanand Ishan , Desai Amit , Bhatt Shweta , Tunuguntla Hari S. , Verma Sadhna
Published: May 2022

The COVID-19 pandemic has caused significant medical and psychological challenges worldwide, and, in many cases, not only exceeded the capacity of hospitals and intensive care units (ICUs) but also an individuals’ ability to cope with life. Health-care workers have continued to provide care for patients despite exhaustion, fear of transmission to themselves and their family members, illness or death of friends and colleagues, and the loss of many patients. They have also faced many additional sources of stress and anxiety, and long shifts combined with unprecedented population restrictions, including personal isolation. This study digitally measured the psychological parameters of health care workers during the COVID-19 pandemic, followed by an app-based yoga of immortal (YOI) intervention. Participants in this study completed validated psychological measures including the Patient Health Questionnaire-8 (PHQ-8), Insomnia Severity Index (ISI) and generalized anxiety disorder (GAD-7) scales. The digital YOI intervention significantly reduced the anxiety, depression symptoms, and insomnia in healthcare workers.
Meier-Gorlin Syndrome: Clinical Misdiagnosis as Jeune Syndrome, Genetic Testing and Functional Analysis of ORC6 Mutations and the Development of a Prenatal Test
Authors: Nazarenko Maria S. , Viakhireva Iuliia V. , Skoblov Mikhail Y. , Soloveva Elena V. , Sleptcov Aleksei A. , Nazarenko Ludmila P.
Published: May 2022

Meier–Gorlin syndrome (MGS) is a rare genetic developmental disorder that causes primordial proportional dwarfism, microtia, absent or hypoplastic patellae and other skeletal anomalies. Overlapping skeletal symptoms make MGS difficult to diagnose clinically. We describe a 3-year-old boy with short stature, recurrent respiratory infections, short-rib dysplasia, tower head and facial dysmorphisms who was admitted to the Tomsk Genetic Clinic to verify a clinical diagnosis of Jeune syndrome. Clinical Exome sequencing revealed two variants (compound heterozygosity) in the ORC6 gene: c.2T>C(p.Met1Thr) and c.449+5G>A. In silico analysis showed the pathogenicity of these two mutations and predicted a decrease in donor splicing site strength for c.449+5G>A. An in vitro minigene assay demonstrated that variant c.449+5G>A causes a complete skipping of exon 4 in ORC6 gene. The parents asked for urgent prenatal testing for MGS for the next pregnancy, but it ended in a miscarriage. Thus, this case report may help to prevent MGS misdiagnosis in the future. We also performed in silico and functional analyses of ORC6 mutations and developed a restriction fragment length polymorphism and haplotype-based short-tandem-repeat assay for prenatal genetic testing for MGS. These findings should elucidate MGS aetiology and improve the quality of genetic counselling for affected families.
Neuroprotective and Anti-Epileptic Potentials of Genus Artemisia L.
Authors: Sailike Bayan , Jin Wei-Lin , Askarova Sholpan , Adilbayeva Altynay , Jenis Janar , Akbay Burkitkan , Omarova Zhannur , Tokay Tursonjan
Published: May 2022

Epilepsy is a chronic neuronal disorder characterized by periodic, unpredictable, and recurrent seizures due to either a genetically determined or an acquired brain disorder. Although many anti-epileptics drugs (AEDs) are developed to control epilepsy, 30% of patients still need additional drugs or experience recurrent seizures and psychiatric and behavioral side effects. Thus, the need for medical care for patients with uncontrolled epilepsy remains unmet. The Genus Artemisia L. is one of the largest genera in the Asteraceae family with more than 500 species widely distributed in Europe, Asia, and North America. Many Artemisia species have been used in various treatments since ancient times as folk remedies. They demonstrated strong antioxidant, anti-inflammatory, antimicrobial, antimalarial, and antitumor activity. Recent studies reveal that some species of Artemisia demonstrated a therapeutic benefit for epilepsy by its anti-oxidant, anti-inflammatory, neuroprotective, and anticonvulsant properties. In this review, we investigate the current state of the literature regarding the neuroprotective and antiepileptic potentials of the genus Artemisia and its possible underlying mechanisms.
The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways. Crosstalk on Perioperative Antioxidant Therapy
Authors: Ritiu Stelian Adrian , Rogobete Alexandru Florin , Sandesc Dorel , Bedreag Ovidiu Horea , Papurica Marius , Popovici Sonia Elena , Toma Daiana , Ivascu Robert Iulian , Velovan Raluca Ramona , Garofil Dragos Nicolae , Corneci Dan , Bratu Melania Lavinia , Pahontu Elena Mihaela , Pistol Adriana
Published: May 2022

Worldwide, the prevalence of surgery under general anaesthesia has increased significantly, on one hand because of modern anaesthetic and pain control techniques, and on the other hand because of better diagnosis and increased complexity of surgical technique. Together with the development of new concepts in the surgical field, the attention of researchers and clinicians turned to minimizing the impact of surgical trauma and offering minimal invasive procedures. This fact is due to the recent discoveries in the field of cellular and molecular mechanisms, that have revealed a systemic inflammatory and pro-oxidative impact that not only lasts in the perioperative period, but also impacts the long term, contributing to more difficult recovery, increased morbidity, and mortality, and finally a negative financial impact. Detailed molecular and cellular analysis have shown an overproduction of inflammatory and pro-oxidative species, that are responsible for an augmentation of the systemic inflammatory status and more difficult postoperative recovery. Moreover, it was shown that there are a series of changes in certain epigenetic structures, the most important being the microRNAs. Based on these findings, a series of modern, targeted therapeutic approaches have been proposed, with the final goal of blocking these mechanisms and reducing the redox state. Recent studies carried out had a positive clinical impact regarding antioxidant therapy and have shown that it can be used in the perioperative period with beneficial clinical impact. This review describes and details the most important molecular and cellular mechanisms that impact the surgical patient undergoing general anaesthesia, and it presents a series of antioxidant therapies that can reduce systemic inflammation.
Sex Differences in Nutritional Status and Associated Risk Factors Among Cardiovascular Disease (Cvd) Patients in Lahore, Pakistan; A Cross-Sectional Descriptive Study
Authors: Faheem Amina , Raza Qaisar , Iqbal Sanaullah , Batool Rakhshanda , Faheem Umer
Published: May 2022

Objective: To explore sex differences in cardiovascular disease (CVD) related risk factors such as diabetes, hypertension, and demographic, anthropometric, biochemical, clinical, and nutritional differences among 40-60 years old Pakistani CVD patients.Design: This was a cross-sectional, descriptive study.Setting: The present study was conducted at the Mayo/King Edward Medical University (K.E.M.U) Hospital Cardiology Department (CCU-I & CCU-II), Lahore, from February 2020 to June 2020. A self-administered questionnaire was used for data collection.Participants: A random sample of 300 cardiac patients was included in the study. Patient records, food frequency questionnaire and 24-hour dietary recall was used to solicit information about demographic, anthropometric, biochemical, and clinical measurements; dietary intake parameters; and CVD risk factors such as hypercholesterolemia, hypertension, diabetes, and smoking. Results: Men CVD patients had higher BMI (33.43 kg/m2 vs. 28.69 kg/m2) and higher prevalence of hypertension (81.1% vs. 59%), hypercholesterolemia (82.4% vs. 54.5%) and smoked more cigarettes (72.6% vs. 9%) as compared to women while there was higher prevalence of diabetes among women as compared to men (59% vs. 29.4%). There were 85% women vs. 80% men consuming white bread, while half of the men reported using meat daily, as compared to only 16.6% women. There were 51.5% women and 17% men who reported consuming fruits and vegetables daily. There were 40% men and 16% women who reported consuming soft drinks. Conclusion: The study showed significant sex differences in the nutritional status and risk factors of patients with CVD.
Development of a Medium Care Unit Using an Inexperienced Respiratory Staff: Lessons Learned During the COVID-19 Pandemic
Authors: Van Hove Olivier , Gillet Alexis , Tack Jérôme , Reychler Gregory , Guaterri Magda , Allarin Asuncion , Thomas Justine , Espinoza Laimito Rolando , Bonnier Frédéric , Norrenberg Michelle , Daniel Pauline , Toussaint Michel , Leduc Dimitri , Bonnechère Bruno , Taton Olivier
Published: May 2022

The different waves of the COVID-19 pandemic caused dramatic issues regarding the organiza-tion of care. In this context innovative solutions have to be developed in a timely manner to adapted the organization of the care. The establishment of middle care (MC) units is a bright example of such an adaptation. A multidisciplinary MC team, including expert and non-expert respiratory nurses, physicians, physiotherapists, psychologists, nutritionists and social workers, was built and trained to work in the COVID-19 MC unit. Important educational resources were set up to ensure rapid and effective training of the MC team, limiting the admission or delaying transfers to ICU and ensuring optimal management of palliative care. We conducted a retrospec-tive analysis of patient data in the MC unit during the second COVID-19 wave. Fifty-two COVID-19 ‘step-up’ patients admitted to the MC unit were included in the study. Thirty-four (65%) patients worsened, of which 12 (23%) were not eligible for ICU access. In total, 42% of the ICU-eligible patients were managed in the MC unit to avoid the ICU. Among the 22 patients transferred to the ICU, 15 were intubated. The establishment of an MC unit during a pandemic, mixing expert and non-expert respiratory team members, is feasible and needed. MC units possi-bly relieve the pressure exerted on ICUs. A highly trained multidisciplinary team is key to ensur-ing the success of an MC unit during a pandemic.
Visualizing CoAtNet Predictions for Aiding Melanoma Detection
Authors: Kvak Daniel
Published: May 2022

Melanoma is considered to be the most aggressive form of skin cancer. Due to the similar shape of malignant and benign cancerous lesions, doctors spend considerably more time when diagnosing these findings. At present, the evaluation of malignancy is performed primarily by invasive histological examination of the suspicious lesion. Developing an accurate classifier for early and efficient detection can minimize and monitor the harmful effects of skin cancer and increase patient survival rates. This paper proposes a multi-class classification task using the CoAtNet architecture, a hybrid model that combines the depthwise convolution matrix operation of traditional convolutional neural networks with the strengths of Transformer models and self-attention mechanics to achieve better generalization and capacity. The proposed multi-class classifier achieves an overall precision of 0.901, recall 0.895, and AP 0.923, indicating high performance compared to other state-of-the-art networks.
Event-Based Emergency Detection for Safe Drone
Authors: Kim Isaac , Kim Hyun-Geun , Kim In-Young , Ohn Sung-Yup , Chi Sung-Do
Published: May 2022

Quadrotor drones have rapidly gained interest recently. Numerous studies are underway for the commercial use of autonomous drones, and especially the distribution businesses are taking serious reviews on drone delivery services. However, there are still many concerns about urban drone operations. The risk of failures and accidents makes it difficult to provide drone-based services in the real world with ease. There have been many studies that introduced supplementary methods to handle drone failures and emergencies. However, we discovered the limitation of the existing methods. The majority of approaches were improving PID-based control algorithms which is the dominant drone control method. This type of low-level approach lacks situation awareness and the ability to handle unexpected situations. This study introduces an event-based control methodology that takes a high-level diagnosing approach that can implement situation awareness via time-window. While leaving the low-level controller to involve in operating the drone for most of the time in normal situations, our controller operates at a higher level and detects unexpected behaviors and abnormal situations of the drone. We tested our method with real-time 3D computer simulation environments with Unreal Engine[15] and AirSim[31]. We were able to verify that our approach can provide enhanced double safety and better ensure safe drone operations. We hope our discovery to possibly contribute to the advance of real-world drone services in the near future.
Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell-induced Apoptosis of Lymphatic Endothelial Cells in vitro
Authors: Hromada Carina , Hartmann Jaana , Oesterreicher Johannes , Stoiber Anton , Daerr Anna , Schädl Barbara , Priglinger Eleni , Teuschl-Woller Andreas H. , Holnthoner Wolfgang , Heinzel Johannes , Hercher David
Published: May 2022

Peripheral nerve injuries pose a major clinical concern world-wide, and functional recovery after segmental peripheral nerve injury is often unsatisfactory, even in case of autografting. Although it is well established that angiogenesis plays a pivotal role during nerve regeneration, the influence of lymphangiogenesis is strongly underinvestigated. In this study, we analyzed the presence of lymphatic vasculature in healthy and regenerated murine peripheral nerves, revealing that nerve autografts contained increased numbers of lymphatic vessels after segmental damage. This led us to elucidate the interaction between lymphatic endothelial cells (LECs) and Schwann cells (SCs) in vitro. We show that SC and LEC secretomes do not influence the respective other cell types’ migration and proliferation in 2D scratch assay experiments. Furthermore, we successfully created lymphatic microvascular structures in SC-embedded 3D fibrin hydrogels in the presence of supporting cells, whereas SCs seemed to exert anti-lymphangiogenic effects when cultured with LECs alone. Here, we describe for the first time increased lymphangiogenesis after peripheral nerve injury and repair. Furthermore, our findings indicate a potential lymph-repellent property of SCs, thereby providing a possible explanation for the lack of lymphatic vessels in the healthy endoneurium. Our results highlight the importance to elucidate the molecular mechanisms of SC-LEC interaction.
Steel Shot as a Risk Factor for Soils at the Area of Shooting Activity
Authors: Lisin Vladimir , Chizhikova Valentina , Lubkova Tatiana , Yablonskaya Daria
Published: May 2022

This study is follow-up of the steel shot transformation under the influence of environmental factors research (Lisin et al., 2022) and is the initial stage of investigating the iron behavior in soils during steel shot corrosion under a number of factors: the metallic lead in soils, atmospheric precipitation, excess organic matter. The results obtained show that corrosion of steel ammunition is a continuous process, including the formation of a poorly soluble rust crust on the surface of the steel and the mineralization of the metal until it is destroyed. As a result, the metal transformed into rust form, is a constant source of iron ions and dispersed rust particles migrating in soil waters and accumulating in soils. In addition, the aggregation of corrosion products of steel ammunition is the cause of a change in physical and mechanical properties of soils, which leads to a violation of the air and water migration regime of soils and an increase in surface runoff from the territories of shooting activity. The highest environmental risks are observed when steel ammunition is used on shooting areas where metallic lead intensifies steel shot corrosion rate, while the deposited steel shot activates the deterioration of previously encapsulated metal and — if steel and lead ammunition are used at the same time — slows down the encapsulation of newly deposited metallic lead, which catalyses the accumulation and migration of lead in environmental components.
Further Validation of the Crohn’s and Ulcerative Colitis Ques-tionnaire-32 (CUCQ-32) to Measure the Quality of Life in Pa-tients Treated with Biologics Therapy
Authors: Alrubaiy Laith , Sikafi Rafid , Hutchings Hayley Anne , Arnott Ian , Williams John G.
Published: May 2022

Background: Crohn’s and Ulcerative Colitis Questionnaire-32 (CUCQ-32) is a validated questionnaire to measure the quality of life (QoL) in inflammatory bowel disease (IBD). However, it does not have stoma specific questions and can be lengthy. This study aimed to validate a subset of the CUCQ-32 that would be suitable for patients with a stoma. Methods: Baseline data were collected from a cohort of patients with acute ulcerative colitis who were participating in the CONSTRUCT multi-centre clinical trial. A subset of the CUCQ-32 questions was selected by stepwise regression. Further validation was examined using data from the UK IBD biological therapies audit. Construct validity was carried out using the EuroQol 5 dimensions (EQ5D) questionnaire, Simple Clinical Colitis Activity Index (SCCAI) and the Harvey-Bradshaw Index (HBI). Literature review and an expert focus group identified supplementary questions to cover patients with a stoma. Test-retest analysis was done during the patients’ second follow up visits. Results: Using the data from 124 patients, a short version questionnaire (CUCQ-12) was developed. Further validation using data from 484 patients with IBD as part of the UK IBD biological therapies audit. Using the data from 61 patients with a stoma, we identified 5 stoma specific questions for the CUCQ-12+. The CUCQ-12+ demonstrated excellent internal consistency (Cronbach’s α= 0.86); established effective reproducibility (intra-class correlation coefficient= 0.74); correlated well with the EQ5D (r= - 0.48), HBI (r= 0.45) and SCCAI (r= 0.43); and represented good responsiveness statistics (>0.5). Conclusions: CUCQ-12+ is a valid and reliable QoL measure that can be used for all patients with IBD in clinical practice including patients with a stoma.
Apple Watch for Pulse Rate Assessment Detects Unidentified Paroxysmal Atrial Fibrillation
Authors: Hirota Kiichi , Hirai Maretoshi
Published: May 2022

Consumer rhythm-monitoring devices, such as the Apple Watch, are becoming more readily available. Irregular pulses can be detected using an optical sensor built into the wearable device. The Apple Watch (Apple Inc., Cupertino, CA, USA) is a class II medical device with pulse rate and electrocardiography (ECG) monitoring capabilities. Here we report a case in which an arrhythmia that was conventionally perceived but undiagnosed was identified as atrial fibrillation by self-acquisition of ECG data using an Apple Watch.
Hogyan beszéljünk a beszédről? Narratív és vizuális gyakorlatok az osztályteremben
Authors: Kresztyankó Annamária
Published: May 2022

A tanulmány egy pedagógiai etnográfiai kutatás eredményeit ismerteti; egy kétéves terepmunka tapasztalataira építve mutatja be felső tagozatos cigány diákok önreflexióit saját beszédmódjaikról. Megvizsgálja, hogy milyen interdiszciplináris megközelítések használhatók az osztályteremben a nyelvi gyakorlatok feltérképezéséhez a pedagógiai etnográfia keretein belül. A kutatás során alkalmazott módszertan – a szociokulturális nyelvi portfólió – elemzése azért is képezi fontos részét a tanulmánynak, mert egyrészt a portfólió narratív és vizuális elemeinek a kidolgozása, valamint a módszertan véglegesítése ebben a két évben valósult meg; másrészt a metodológiai lépések pontos leírásával lehetőség nyílik a módszer felhasználására. A szociokulturális nyelvi portfólió segítségével pedig nemcsak a nyelvi, hanem az etnikai és a nemi identifikáció „határai” és „határátlépései”, valamint a tanulók jövőképe is kirajzolódik – hiszen a módszer a vizualitást használja fel ahhoz, hogy kimondhatóvá váljon a beszédmódok sokfélesége.
A szövegértés mérése a történelemórán feldolgozandó szövegtípusokon 11. évfolyamos tanulók körében
Authors: Simon Viktória
Published: May 2022

A szövegértési nehézséggel küzdő tanulók minden tantárgy esetében hátránnyal indulnak. Mivel minden tantárgynak – így a történelemnek is – megvannak a saját szövegtípusai és az ezekhez kötődő feldolgozási módjai, olvasási stratégiái, a szövegértés szaktárgyi megközelítése új szemléletet jelenthet a hazai oktatásban. Jelen tanulmány célja annak a vizsgálata, hogyan befolyásolják a történelemhez kapcsolódó tantárgyspecifikus szövegtípusok a szövegértés eredményességét. A 11. évfolyamos tanulók körében végzett vizsgálat alapján elmondható, hogy a szövegtípus befolyásolja az eredményességet. A folyamatos szövegek esetében jobb eredményt értek el a tanulók, mint a verbális-multimediális nem folyamatos szövegek esetében (ábra, táblázat). A verbális-multimediális szövegek között pedig a táblázatok értelmezésében születtek jobb eredmények, és kevésbé jók az ábrák esetében. Érdemes lehet a továbbiakban olyan szövegtípusonkénti célzott fejlesztést kidolgozni, amely a történelem tantárgy keretei között alkalmazható.
Vizualitás és kollaboráció az anyanyelvi órán
Authors: Könnyü Laura Krisztina
Published: May 2022

A dolgozat az iskolai kollaboráció és a vizualitás összekapcsolhatóságát mutatja be online szerkesztőprogramokkal elkészíthető, az anyanyelvi órán használható gyakorlatokon és ezek alkalmazhatóságán keresztül. Az elméleti keretet a tanórai és tanórán kívüli, valamint az online, illetve offline kollaboráció jellemzése és különféle grafikus szervezők (fogalmi és gondolattérképek, táblázatok, infografikák) elméleti bemutatása adja. Az elméleti összefoglalót különböző online szerkesztőprogramokkal (Canva, Linoit, Realtimeboard) létrehozott mintafeladatok és az ezekhez kapcsolódó módszertani megjegyzések, gyakorlati tanácsok követik, amelyek a gyakorló pedagógusok módszertani eszköztárának a bővítését szolgálják, különös tekintettel a tanulói együttműködést igénylő, csoportos munkaformára épülő tanórai tevékenységekre.
Többszörös intelligencia a helyesírás-tanulás gyakorlatában
Authors: Kézdy-Brózik Vera , Lengyel Zsuzsa
Published: May 2022

Howard Gardner nagy hatású elmélete szerint nemcsak az IQ-tesztekkel mérhető nyelvi és logikai képesség van: létezik képi, mozgásos, zenei, természeti, társas és személyes intelligencia is. Ezt a hagyományos iskolarendszer kevésbé értékeli, és kevésbé használja fel a tanulás folyamatában. A tanulmányban szereplő ötletek abban nyújtanak segítséget, hogy a diákok saját érdeklődésüknek, tehetségüknek megfelelően, a maguk módján tanulhassanak meg és gyakorolhassanak egy-egy írásmódot vagy helyesírási szabályt. A feladatok változatai lehetőséget adnak arra, hogy különböző évfolyamokon lehessen használni őket. A gyűjtemény bármilyen tananyag kiegészítő részeként használható változatlan formában, a kidolgozott lépésekkel, táblázatokkal, szövegekkel együtt, vagy ki-ki saját kedve, lehetőségei, kreativitása és a csoport igényei szerint alakíthatja tovább.
A kommunkáció rejtett zavara: a pragmatikai kommunikációs zavar
Authors: Svindt Veronika
Published: May 2022

A pragmatikai kommunikációs zavar (PKZ) mint önálló diagnosztikai kategória a 2013-ban kiadott DSM-5-ben jelent meg a nyelvi és kommunikációs zavarok között. A nemzetközi gyakorlatban az 1980-as években írták le először olyan gyermekek tüneteit, akik a felszínen tipikusnak tűnő nyelvfejlődési útjuk ellenére súlyos szociális-kommunikációs és pragmatikai nehézségekkel küzdenek (Rapin‒Allen 1983). Hazánkban jelenleg kezdeti szakaszban jár ennek a fejlődési zavarnak a meg- és felismerése, szűrése, diagnosztikája, illetve az intervenció módszereinek kidolgozása. A PKZ-val élő gyermekek ‒ a gyakran rejtve maradó fejlődési zavaruk következtében ‒ iskolai előmenetelük során tipikusan fejlődő kortársaikhoz képest egyre nagyobb és látványosabb hátrányba kerülnek, és ez tanulási nehézségekben, magatartási és viselkedési problémákban, figyelmi nehézségekben, szociális és kommunikációs esetlenségben nyilvánul meg. Jelen tanulmány célja a PKZ tüneteinek, hétköznapi megnyilvánulási formáinak a megismertetése a gyakorló pedagógusokkal annak érdekében, hogy felismerjék a tanítványaik között esetleg érintett gyermekeket.
A nyelveredet-nyelvrokonság témakör oktatása projekttel. Módszertani lehetőségek és tanári tapasztalatok
Authors: Takács Judit
Published: May 2022

A 2020-ban megújított Nemzeti alaptantervben az általános iskola 8. és a középiskola 12. évfolyamán a korábbi évekhez képest kevesebb idő és óraszám jut a magyar nyelv eredete és rokonsága témakör megismertetésére. A szűk időkeret és a komplex téma a frontális módszerek, elsősorban a tanári magyarázat felé fordítják a tanárokat, ám ennek hatékonysága a téma komplexitása miatt sokszor meglehetősen alacsony. A köznevelésben immár második tanévben zajló tantermen kívüli (digitális) oktatás felerősítette az igényt az olyan módszerek iránt, amelyek lehetőséget adnak a tanórán kívüli, otthoni tanulásra és az egyéni vagy csoportos témafeldolgozásra. Korábbi kutatások azt mutatják, hogy ezek közül a projektmunka a ritkán használatos módszerek közé tartozik. Ebben a témakörben, a magyartanárok körében készült egy kutatás, amely alátámasztotta a korábbi vizsgálatok eredményeit. Azok a tanárok, akik mégis használják a fenti témakör oktatásában a projektmódszert, a projektet hatékony, sikeres oktatásszervezési módként írják le.
IS ABERRANCY A RELIABLE INDICATOR FOR MAJOR PALEOCLIMATIC DISTURBANCE?
Authors: STUKINS STEPHEN
Published: May 2022

Aberrant forms of many different spore and pollen taxa (sporomorphs) are often used to assess timings and extent of environmental stress at major extinction/climate events. However, little is known about the normal level of malformations in these taxa. Malformation can manifest in several different ways, including significant size differences (± from the accepted range for the species), retention of pollen/spores within tetrads, and unusual and inconsistent morphological aberrations. This study analyses one commonly used pollen genus, Classopollis, and its aberrant forms, from the Bajocian of Argentina. Tetrads, including those incorporating malformed/aborted pollen grains, are found to be common, showing that tetrads of Classopollis are not a reliable signal of major environmental disturbance. The results and discussion presented here emphasize why palynological data must be interpreted in context of the depositional dynamics, facies changes and how they affect the assemblages in conjunction with understanding variations in the strategies of individual flora.
In the World of Philosophers and Philosophy (On the Ninth Edition of the Philosophical Dictionary)
Authors:   Lomonosov Moscow State University, Zhukov Vyacheslav N.
Published: May 2022

The article is devoted to the publication of the 9th edition of the Philosophical Dictionary. It is noted that 80 years have passed since the first edition (1939), and the dictionary, on the one hand, has undergone significant changes, on the other hand, it has preserved the best traditions of the national philosophical school. The “Philosophical Dictionary” is not just a navigator on the world philosophical thought, it is a kind of face of our national philosophy, created by several generations of philosophers (pre-revolutionary, Soviet and post-Soviet formation). The authors of the articles are recognized experts in their field, very often they are the classics of our philosophical thought. A characteristic feature of the dictionary is the combination of a high theoretical level with an accessible, clear presentation of the material. World philosophy is traditionally presented in the dictionary in the form of philosophical directions (on theoretical, methodological and subject grounds), terms and personalities, which provided a multifaceted analysis of philosophical problems. The historical and philosophical material is characterized by completeness, attention is paid to both the philosophy of the past and the latest philosophical trends and schools. The peculiarity of the publication is that it presents articles on philosophies of many cultural regions and countries. The trend of the latest editions of the dictionary is an increase in the volume of articles on Russian philosophy. This is caused by the increased interest in it. Moreover, the world philosophy presented by our authors is one of the forms of Russian philosophy. The interpretation of problems, studies, names presented in world philosophy is the face, the essence of our fatherly philosophical school.
Input and output consideration in the assignment and transportation problems
Authors: Ghiyasi Mojtaba , rouyendegh babak , Taspinar Asli , ciftci kamil , Ekong Joseph
Published: May 2022

Transportation and assignment problems are subject of extensive research focusing on the optimization of shipping routes and utilization of resources to decrease costs or increase profits. In this work, these approaches are generalized to cases with multiple inputs/outputs, while improving the discrimination power and reducing the computational complexity compared to the existing models. The applicability and strength of our model is also demonstrated by applying it to practical scenarios alongside these conventional approaches.