bluuebunny/crossref_metadata_2025 huggingface dataset:
Rupture of Left Horn of Bicornuate Uterus at 19 Weeks
Authors:   Postgraduate, Department of Obstetrics and Gynaecology , Sir Devaraj Urs Medical College, Kolar., Jayaraj Rashmi S , S R Sheela , P N Sreeramulu
Published: February 2023

Congenital malformations of uterus are a well discussed entity. We report a case of bicornuate uterus with pregnancy in the left horn with an unusual presentation. It was diagnosed at 19 weeks of gestation at our hospital, exploratory laparotomy with excision of the left ruptured horn of the uterus was done. Haemorrhage occurring because of rupture of cornuate uterus is massive and can be life threatening. Hence it should be diagnosed early and treated promptly. Key words: Congenital Malformation, Cornuate Uterus
Flour and Dough Quality of Millets and Their Suitability for Preparation of Traditional South Indian Roti
Authors:   Professor and HOD,Department of Clinical Nutrition and Dietetics, SDUAHER, Tamaka, Kolar,, Reddy Madhavi , C.S Shivakumara , Aneesha Aneesha
Published: February 2023

Background: India is a land of millets. Millets are the most nutritious grains. India contributes to world’s 35% production but the consumption of millet and their products is limited. Objectives: The present study is to determine the flour and dough quality of different milletsand their Suitability for Preparation of Traditional South Indian Rotis (viz., Finger Millet, Kodo Millet, Foxtail Millet, Pearl Millet, Barnyard Millet, Little Millet, Proso Millet and Sorghum). Materials and Methods: Eight varieties of millets were procured from local market of Kolar and utilized for the study. Results: Among the eight varieties millets roti, the Little Millet roti scored highest among all and was at par with control sample. The appearance of Sorghum roti and flavor of foxtail millet roti was found as on par with the control sample. Conclusion: Hence it can be concluded from the sensory evaluation of among the eight millets roti sam-ples overall acceptability was found in Little Millet roti. Key Words: Millets, bulk density, Swelling capacity, Rollability,
Interesting Case of Solid Pseudopapillary Epithelial Neoplasm of Pancreas (SPEN) In A Pregnant Woman
Authors:   3rd year post-graduate, Department of Radiodiagnosis,Sri Devaraj Urs Medical College, Kolar. 2. Prof. and HOD, Department of Radiodiagnosis,Sri Devaraj Urs Medical College, Kolar., P.M Athira , N Rachegowda. , Yadav Gaurav , Madhukar M. , Ranganath Amrutha
Published: February 2023

Solid pseudopapillary tumours (SPT) are rare, cystic neoplasm of the pancreas with low malignant potential. It usu-ally occurs in females in second to third decade of life and have favourable diagnosis. We present a case of SPT which was diagnosed incidentally in a 19 year old pregnant female at 12 weeks who later had an abortion at 20 weeks of gestation. Pan-creatic pseudopapillary tumors are rare neoplasms with low malignant potential and sound be kept as differential diagnosis while evaluating pancreatic tumors. Keywords: Papillary Tumors, Pancreas.
A Study of Cord Blood Albumin as a Predictor of Significant Neonatal Jaundice
Authors:   Senior Resident, Department of Paediatrics, Sri Devaraj Urs Medical College, Tamaka, Kolar, Harisha Challa , VR Sudha Reddy , KN Shashidhar
Published: February 2023

Background: Neonatal hyperbilirubinemia is the commonest abnormal physical finding during the first week of life and its early detection is essential for prevention of bilirubin encephalopathy. Early discharge of healthy term neonates is a com-mon practice due to various reasons. The commonest cause for readmission of a normal neonate during early neonatal peri-od is neonatal hyperbilirubinemia. Readmission causes considerable stress to the family members. Aims: To assess whether cord blood albumin level could be used to predict the occurrence of significant jaundice requiring intervention. Settings and Design: It is a prospective study undertaken in postnatal wards of a teaching hospital. Material and Methods: Cord blood albumin was estimated in 130 healthy term neonates and they were divided into 3 groups based on cord blood albumin levels as follows: Group 1 with albumin levels <2.8g/dl; Group 2 with albumin levels between 2.8 and 3.3 g/dl and Group 3 with albumin levels of > 3.3g/dl. All the enrolled neonates were followed up for 72 hours and observed for clinical jaundice based on yellowish discoloration of skin. Neonates with evidence of clinical jaun-dice were subjected to total serum bilirubin estimation and hour specific values were plotted on Bhutani’s charts. Results: Clinical jaundice was present in 100 neonates for whom serum bilirubin estimation was done. There was a signifi-cant negative correlation between cord blood albumin levels and total serum bilirubin. Out of 100 neonates with clinical jaundice, 19 received phototherapy for significant hyperbilirubinemia. While all neonates in Group 1 received phototherapy none in Group 3 received intervention which was highly significant (p value <0.0001). Conclusion: Cord blood albumin estimation helps in predicting the possibility of hyperbilirubinemia in healthy term neo-nates. Key words: Cord blood albumin, Neonatal hyperbilirubinemia, Phototherapy
Usefulness of Phytochemicals as Anticancer Drugs
Authors:   Department of Cell Biology and Molecular GeneticsSri Devaraj Urs Medical Collage, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar -563101, Karnataka, India., Kutty Dr. A.V.M.
Published: February 2023

Cancer is a state of uncontrolled proliferation and dedifferentiation of cells in any tissues or organs of the body. The incidence of cancer is rising alarmingly and is one of the leading causes of morbidity and mortality globally. Normal cell division is precisely a planned biological process controlled by regulatory genes and specific metabolic pathways. Exposure of normally functioning cells to carcinogens leads to mutations in the genes causing loss of control of cell division and transform into cancerous. Over a period of time, these cancer cells acquire more mutations; invade to adjoining tissues, escape the process of apoptosis and the cells become eternal. Breakaway parts of the cancer tissues / cells travel through the lymphatic and blood vessels and get deposited in other tissues / organs leading to metastasis, the spread of cancer.
Maternal serum biomarkers in early diagnosis of preeclampsia
Authors:   PhD Scholar, Department of Biochemistry, Sri Devaraj Urs Medical College, Kolar., Gandham Rajeev , ME Sumathi , CD Dayanand , SR Sheela , P Kiranmayee
Published: February 2023

Background: Preeclampsia (PE) is a pregnancy specific disorder, characterized by new onset of hypertension and proteinuria after 20 weeks of gestation. It is one of the leading causes of maternal and perinatal morbidity and mortality. The etiology of the disease process in not known. There is an urgent need for a 1st trimester marker for the prediction of preeclampsia. Recent studies have reported that this disease originate from abnormal placentation and maternal endothelial dysfunction. The intense research in this arena has unveiled some important serum biomarkers which play an important role in placentation. These markers include angiogenic and antiangiogenic molecules. However, these markers when they used alone are not effective for the prediction of preeclampsia, but in combination may help in predicting women who are likely to develop preeclampsia. This review summarizes the various maternal serum biomarkers available and utility in predicting preeclampsia. Keywords: Preeclampsia, Biomarkers, Angiogenic markers, Antiangiogenic markers, Apelin
An interesting case of disseminated tuberculoma of brain and spinal cord
Authors:   Department of Radio-Diagnosis, Sri Devaraj Urs Academy of Higher Education & Research, Tamaka, Kolar, Karnataka., B H Parameshwar Keerthi , Sakalecha Anil Kumar , S Varun , Savagave Shivaprasad G , Raveesha Raveesha
Published: February 2023

Tuberculosis is a public health problem worldwide causing significant morbidity and mortality. Manifestations of tuberculo-sis are widely classified as pulmonary and extra pulmonary. Tuberculoma is one of the CNS manifestations, which on imag-ing shows ring enhancing lesions. Although intracranial tuberculomas are common, spinal tuberculomas are rare and consti-tute only 2% of CNS tuberculomas. We present a case of both intra-axial and spinal tuberculoma in the same patient. Keywords: Tuberculosis, CNS, Tuberculoma, Ring enhancing lesion, MRI
Ompholocele in Adult Female: A Rare Case Report and a Review
Authors:   Department of Anatomy, Sri Devaraj Urs Medical College, Tamaka, Kolar-563103., Changalvala Krishnaveni , K.V Venkateshu , K Shashidhar.
Published: February 2023

Ompholocele is defined as congenital abdominal wall defect with herniated abdominal viscera due to weakness in ab-dominal wall. The incidence of ompholocele is more common in males compared to females. The survival rate depends on severity of complication. During routine dissection of formalin fixed female cadaver in Department of Anatomy, SDUMC, ob-served a mass in right, lower quadrant of lumbar region with mesentery, blood vessels bulged out through right side open-ing. The liver, cecum and appendix were in midline but not in anatomical positions in cadaver. This condition was named as isolated ompholocele. Isolated Ompholocele in female cadaver is a rare case report. Keywords: Abdominal hernia, Giant Ompholocele, Abdominal wall defects, Gut rotation, Exomphalos
Traumatic Chlye Leak In Neck: An Uncommon and Serious Complication
Authors:   Department of ENT Sri Devaraj Urs Medical Collage, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar -563101, Karnataka, India., Mohiyuddin Dr. S M Azeem
Published: February 2023

The lymph from the entire left side of body and right side of body below the diaphragm flows through the thoracic duct. The lymph from rest of the body flows through the right thoracic duct. It also carries chyle from intestines, partially digested long chain fatty acids and chylomicrons. The tho-racic duct develops from the fusion of the 2 lymphatic ducts present from the 8th week of intrauterine life and fuse before birth. There can be connections between remnants of the 2 lymphatic ducts or branching from the thoracic duct. The thoracic duct originates from cisterna chyli situated at the level of 2nd lumbar vertebra, runs between the Aorta and Az-ygous vein and passes behind the Aortic arch and is situated lateral to the esophagus. At the root of the neck it lies be-tween the common carotid and internal jugular vein anteri-orly, inferior belly of omohyoid laterally, scalenius anterior branchial plexus and phrenic nerve posteriorly and esopha-gus medially. It terminates in the venous system by draining into internal jugular vein or confluence of internal jugular vein and subclavian vein or in few cases into the subclavian vein. Variations are common in anatomy of the thoracic duct.[1]
Qualitative and quantitative phytochemical analysis of Allium cepa L springs with a focus on its biological activity: A pilot study
Authors:   Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar—563 103, Karnataka, India., Inala Mary Shobha Rani , P Kiranmayee , A. V. M. Kutty
Published: February 2023

Background: A preliminary work was carried out on phytochemical analysis and biological importance of Allium cepa springs. Materials and Methods: Three different extractions were made from Allium cepa springs using hexane, ethyl acetate and ethanol. Antioxidant, anti-hemolytic, antibacterial and sun protection factor properties were performed and compared among the three extracts. Results: The extracts contained alkaloids, phenolics, saponins, flavonoids, carbohydrates, tannins and glycosides, based on phytochemical screening. Among the three solvents used, and from all the tests, the highest biological activity was observed in ethyl acetate extract for antioxidant (1.2mM), sun protection factor (14.1) and anti-hemolytic (95%). Likewise, for antibac-terial assay, Pseudomonas aeruginosa was selected and among the three prepared extracts tested, ethyl acetate extract exhib-ited the maximum zone of inhibition of 22 mm than the other two extracts. The extracts also have RBC protective activity when given as antileukemic to the patients and can be mixed with other formulations in preparing herbal sun protection lo-tions or creams. In vivo studies by using ethyl acetate A. cepa spring‘s extract will guide to develop new drug for the studied parameters. Further research is encouraged on the pharmacokinetics of the active components of ethyl acetate extract that contribute potential biological activity. Conclusion: The quantitative determination of A. cepa springs has revealed abundance of flavonoids among all the other phytochemicals. The ethyl acetate extracts of A. cepa springs possessed potential antioxidant, SPF, anti-hemolytic and anti-bacterial activities and proved to have good pharmacological properties. Key words: Allium cepa, antioxidant, anti-hemolytic, antibacterial, Sun Protection Factor
Cervical Rib-A Radiological Study In Indian Population
Authors:   Professor, Department of Anatomy, Kempegowda Institute of Medical Sciences, Bangalore, Karnataka, Bajpe Roshni , N.S Ashwini.
Published: February 2023

Background: Cervical rib is an extra rib present in neck in 1-2% of population. It is usually unilateral and in some cases bi-lateral .To determine if a cervical rib is present requires an X-ray Knowledge of clinical appearance & radiographic character-istics of cervical rib would enable differential diagnosis in and around this area with aim of easier orientation and faster arri-val at final diagnosis. In this study the focus is on different types of cervical rib radiographs which has been collected from department of radiology. Material and Methods: 100 Chest x-rays with apical lordotic views and cervical spine were obtained from Department of Radiology. Complete and incomplete cervical ribs were observed in the study. Results: Frequency of Cervical ribs in our study matched with the findings of general population. Conclusion: Cervical rib may be an incidental finding in a small percentage of normal people. It is not necessary for this to cause any symptoms however an occasional patient may have symptoms pertaining to this. Keywords: Cervical rib,Thoracic outlet syndrome, Brachial plexus
Qualitative Study on Lived-In Experiences of Foot Ulcer patients
Authors: G Vijayalakshmi , Aryal Debu , Ponnacahan Princymol , Paul Angel grace , C Atheertha , Jalesh Haripriya , Babu Christeena , B Monisha , Chethan Chethan , Swathishree Swathishree
Published: February 2023

Background: Foot ulcer has become the most serious and costly complication, leading to possible amputation or even death. Hence the present study was undertaken with an objective to assess the lived-in experiences of foot ulcer patient at selected hospital, Kolar with a view to develop an information booklet. Aims: To assess the lived-in experiences of foot ulcer patient with a view to develop an information booklet. Settings and Design: An exploratory approach with Phenomenological research design Methods and Material: Through purposive sampling technique 12 foot ulcer patients who were willing to participate in the study were included. Then data was collected through focus group discussion and in-depth interview using open ended ques-tions. Statistical analysis used: The collected data was then analyzed using coding system. Results: From the study six themes were emerged such as lack of awareness, risk of foot ulcer, helplessness, in accessible health care, financial burden and expectations from health authorities. Conclusions: The study concludes that there is an urgent need to educate all foot ulcer patients as well as Diabetes mellitus patients on prevention of foot ulcer in order to prevent further complication. Keywords: Foot ulcer, lived-in experiences, qualitative study, foot ulcer patients.
Niosomes: A novel drug delivery system and its Therapeutic uses
Authors:   Assistant professor, Department of Pharmacology, Sri Devaraj Urs medical College, Tamaka, Kolar., S Harish , K Bhuvana
Published: February 2023

Administration of medications to specific targets with minimal affinity to other organs is a challenge during treatment of disease conditions. Drug-delivery systems which are Target-specific enable the localization of drugs to their site of action. These Targeted drug delivery systems utilize various carriers, such as serum proteins, liposomes, synthetic polymers, and microspheres. Niosomes, are a type of drug delivery system which has a bilayer structure made of non-ionic surfactants. Nio-somes are amphiphilic hence they can encapsulate both lipophilic or lipophobic drugs and increase their bioavailability. This review describes the structure, methods of preparation and applications of niosomes in various diseases. Keyword: Niosomes, Drug Delivery, Therapeutic Uses
Sjogren's Syndrome Presenting with Refractory Hypokalemia and inflam-matory peripheral vascular disease: Double Trouble
Authors:   Junior Resident, Department Of Medicine, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Ahmed Rumaisa , Kumar Prasanna , Imran Tameem
Published: February 2023

Sjogren's syndrome is a slowly progressing autoimmune disease that is characterized by lymphocytic infiltra-tion of the exocrine glands resulting in impaired secretory function. There are varied causes of quadriparesis ranging from cervical cord myelopathy to neuromuscular junction disorders. Even though hypokalemia is a fre-quent cause of quadriparesis but is usually due to periodic paralysis. Here we present a case in which hypokale-mia secondary to Sjogren’s syndrome presented with quadriparesis, which progressed, to respiratory paralysis. Keywords: Sjogren's syndrome, distal renal tubular acidosis, hypokalemia, peripheral vascular disease
Difficulties In Managing Methemoglobinemia
Authors:   Professor, Department of General Medicine, Sri Devaraj Urs Medical Collage, Sri Devaraj Urs Academy of Higher Education and Research, Kolar., K Prabhakar , A Anitha , Ahmed Rumaisa
Published: February 2023

Acute poisoning with nitrobenzene causing significant methemoglobinemia is a rare yet life-threatening emergen-cy. A 20-year-old, female presented to Emergency in altered sensorium with a history of consumption of a bioor-ganic formulation. On examination she was cyanosed restless and agitated with SpO2 of 70% on room air. Blood samples drawn for ABG was chocolate brown colour on blotting paper. ABG showed metabolic acidosis with a satu-ration of 80%. Methylene blue 50mg in IV saline was given over 5 mins and oral ascorbic acid. She improved slowly after the 9th day with SpO2 of 92% on room air. She was discharged on the 17th day on oral iron, ascorbic acid, and breathing exercises. Early aggressive management of severe poisoning, strongly suspected on clinical grounds may change the outcome of the patient. Key-words: Nitrobenzene, methemoglobinemia, methylene blue, pulse oximetry
An ounce of protection is worth a pound of cure: Periodontal management of Phenyto-in Induced Gingival Enlargement
Authors:   Associate Professor, Department of Dentistry, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, C Deepa
Published: February 2023

Gingival enlargement (GE) is a condition of apprehension for both the patient and the doctor. GE can be due to inflammatory, idiopathic or drug induced. Drug induced gingival enlargement (DIGE) is an undesirable side effect resulting from intake of drugs like calcium channel blocker, immunosuppressant and anticonvulsants. Phenytoin an anticonvulsant drug has been associated with a characteristic oral presentation known as Pheny-toin induced gingival enlargement (PIGE). Clinicians need to be aware of the possible side effects of Phenytoin and the treatment options available in order to minimize chances of gingival enlargement. The present case report shows the management of PIGE in a 25yr old female patient with Periodontal therapy by nonsurgical and surgical treatment approach. Key Words: Gingival enlargement, Drug induced gingival enlargement, Phenytoin induced gingival enlarge-ment
Role of Self Directed Learning in Competency based Medical Education in creating an Indian Medical Graduate
Authors:   Director, University Department of Medical Education and Professor and HOD, Department of Physiology, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar -563101, Karnataka, India, M S Dr. Vinutha Shankar
Published: February 2023

Competency based Medical Education (CBME) has been the buzz word of recent times. As a welcome step, MCI has released the much awaited Undergraduate Medical Regulations in 2019 which is based on the VISION document which was conceived a few years ago by medical educators spread across the nation. The end product of this educational model is the Indian Medical Graduate (IMG). The construct for CBME relies on four foundations1: 1. Focusing education on patient outcomes 2. Emphasizing learner abilities 3. De-emphasizing time based learning 4. Increasing individualized trainee plans for the learner Greater emphasis is laid on hands on training, small group teaching and self-directed learning (SDL). Learners are expected to take active part and share responsibility of their learning
Awareness about Mass Drug Administration in one of the Filaria Endemic Districts of North Karnataka
Authors:   Professor and HOD, Department of Community Medicine, S Nijalingappa Medical College, Bagalkot, Dorle A S , Anjum Waseem , Mannapur B S
Published: February 2023

Background: Lymphatic Filariasis (LF) is the world's second leading cause of long-term disability with many serious economic and social consequences affecting many young working adults of both sexes. An estimated 49 million individuals in India are infected with LF of these, over 23 million people suffer from chronic forms of filariasis. The present study was conducted to assess the program effectiveness of the 2-drug strategy in terms of awareness of MDA, source of information of MDA and the adverse effects due to DEC. Objectives: To evaluate the MDA Programme with respect to its awareness, source of information of MDA and the adverse effects due to DEC. Materials and Methods: A Community based Cross-Sectional Study was conducted in Bijapur District. One ur-ban and three rural clusters were selected randomly out of four clusters. All the sampled eligible population who belong to the MDA campaign area were included. Data was collected using pretested proforma, entered in Microsoft Excel 2013 and analysed using free version of OPENEpi software. Results: In the present study out of 713 study population, 67.6% of the population were in the age group of 14-60 years. Male to female ratio was equal. 66.48% of the study population were from rural area and 33.52% were from urban area. 98.39% of them did not experience any side effects. 84% of the study subjects were not aware about MDA. Conclusions: The awareness of MDA was very minimum. Side effects of DEC was also less. Key words: Mass drug administration, Lymphatic Filariasis, DEC
Correlation of Serum Uric Acid Level to Perinatal Outcome in Preeclamptic Women
Authors:   Final year postgraduate, Department of Obstetrics and Gynaecology , Sir Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar., Jayaraj Rashmi S , S R Sheela , Singh Sneha
Published: February 2023

Background: Hypertensive disorders are common in pregnancy. Several studies showed a positive correlation between elevated maternal serum creatinine and adverse maternal and fetal outcomes in pre eclamptic women, but only a few studies are available on serum creatinine and maternal and fetal outcomes. The present study was under taken to study the association of maternal serum uric acid with fetal outcomes in pre eclamptic women. Aim and objective: To Study correlation of serum uric acid level to perinatal outcome in preeclamptic women: Material and Methods : The Study was performed on two groups of women with hypertensive disorders of pregnancy; the first group (n=50) with a serum uric acid level of ≥6mg/dl was compared to the second group (n=50) with a serum uric acid level of <6mg/dl. Perinatal complications like IUFD (Intra-Uterine Fetal Death), low APGAR score, IUGR (Intra-Uterine Growth Retardation) NICU admissions, prematurity and perinatal death were studied. Results: In the present study perinatal outcome was studied among 100 pre eclamptic women. In group A, there were 22 pre-term babies , 20 IUGR and 41 babies had low APGAR (<7) In group B, 9 preterm babies, 12 IUGR, 28 babies with low APGAR (< 7). So these entire abnormal fetal outcomes were higher in Group A (uric acid ≥6mg/dl) .In group A, there were 29 babies required NICU admission, 11 perinatal deaths. In group B, 17 babies required NICU admission and 5 perinatal deaths. Conclusion: Maternal serum uric acid concentration is a good predictor of foetal outcome in women with preeclampsia/ eclampsia. Key words: Uric acid, Creatinine, Pre eclampsia, Gestational age , Birth weight
Effectiveness of Motivational Therapy on Enhancing Self-esteem, to maintain Absti-nence among Alcohol Dependent Patients in Sri Sai Foundation psychiatric hospital, Tamaka, Kolar.
Authors:   Tutor, Department of Psychiatric Nursing Sri Devaraj Urs College Of Nursing . Tamaka, Kolar., M Ramya , Aruna Jairakini , R Rajesh
Published: February 2023

Background:Motivational therapy is very important among alcohol dependent patients to increase the self-esteem to bring the changes in the level of confidence, positive health, problem solving abilities, maintaining abstinence from the alcohol.1 Hence the researcher felt the need to improve the self-esteem level of alcohol dependent patients to maintain abstinence from alcohol in selected de-addiction centres, kolar. Objective: To find out the effectiveness of motivational therapy on enhancing self-esteem to maintain absti-nence among alcohol dependent patients. Materials and Methods: An evaluative approach with Pre experimental one group pre-test, post-test design was adopted. Rosenberg self-esteem scale was used to collect the data. The main study was conducted at Sri Sai Foundation and Life Care Centre Kolar with the sample size of 80 alcohol dependent patients, by using Non- probability, convenient sampling technique and the collected data were analyzed and interpreted by using de-scriptive and inferential statistics. Results: The findings of the study revealed that 100% (80) of alcohol dependent patients had low self-esteem level before Motivational therapy. Whereas after Motivational therapy 100% (80) of the alcohol dependent pa-tients had reached to normal self-esteem level. Further study revealed that after Motivational therapy mean scores of self-esteem level i.e 18.75 with SD of 2.14 was higher than before Motivational therapy mean score i.e 9.51with SD of 1.58 .The obtained t value 32.2 was greater than the table value (1.960) at 0.05 level of signifi-cance which indicates that Motivational therapy was effective on enhancing self-esteem levels of alcohol de-pendent patients. Conclusion: The self-esteem level of alcohol dependent patients was low before Motivational therapy whereas after Motivational therapy all the patients had reached to normal self-esteem level. Hence Motivational therapy is effective in improving self-esteem level of alcohol dependent patients. Key words- Effectiveness, Motivational therapy, Self-esteem, Abstinence, Alcohol Dependent patients
Molecular factors in the development of vitiligo
Authors:   Ph.D. Scholar, Department of Cell Biology & Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar., Venkatesh Vaibhav , Mendez Deena C , T S Rajshekhar , Balakrishna Sharath
Published: February 2023

Vitiligo is a chronic autoimmune disease, caused due to selective destruction of melanocytes. It is characterized by depigmentation of skin. The mechanisms that underlie this phenomenon has not been clearly understood. Therefore, the aim of this review was to collate all the emerging information regarding the involvement of molecular components in vitiligo pathogenesis. Initial surveys suggested that certain chemicals were responsible for causing this skin disease. Recent genetic studies like twin studies show that vitiligo arises due to hereditary factors. Certain predisposing risk variants have been identified through can-didate gene studies and Genome-Wide Association Studies (GWAS). Skin biopsies and peripheral blood of vitiligo patients have revealed the presence of melanocyte targeting autoantibodies, increased T-cells and high levels of inflammatory cytokines, indicating that both humoral and cellular immunities play a major role in selective destruction of melanocytes. In addition to this, studies have shown the association of vitiligo with other autoimmune diseases, implicating that complications of other autoimmune diseases could lead to the development of vitiligo. Further research is required to understand the immune pathway of vitiligo and its commonness with other autoimmune disorders. This would help in tackling the disease therapeutically. Keywords: Vitiligo, Genetics, Autoimmunity, Human Leukocyte Antigen, Cytokines
Case Report Of Short Rib Polydactyly Syndrome
Authors:   Postgraduate, Department of Radio-diagnosis,Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar., Singh Anshul , Sakalecha Anil Kumar , Rajeswari Rajeswari , L Yashas Ullas
Published: February 2023

Short rib polydactyly syndrome (SRPS) is a group of skeletal dysplasias manifested by short-limb dwarfism, short ribs with thoracic dysplasia and polydactyly. SRPS is an inherited autosomal-recessive disorder with dif-ferent prenatal sonographic and postnatal clinical, histological and radiologic findings. In this report, we pre-sent a case of SRPS type 3 (Verma-Naumoff) with thoracic hypoplasia, short limbs and postaxial polydactyly in a 30-week fetus. Keywords: Short rib polydactyly syndrome, Verma-Naumoff, Ultrasonography, Narrow thoracic cage
An Interesting Case Of Bronchial Asthma
Authors:   Professor, Department of Medicine, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tmaka, Kolar., K Prabhakar , A Anitha , B.R Sindhu , Jithendra Jithendra
Published: February 2023

Acute pulmonary embolism is a component of venous thromboembolism (VTE), which may prove fatal if not suspected and subsequently treated. Here we present a 82 year female patient with Bronchial asthma who de-teriorated and developed pulmonary thromboembolism during the hospital stay. Acute pulmonary embolism in elderly asthmatics is not very uncommon. Asthmatic presenting with acute onset of dyspnea, pulmonary embolism should be kept as a possibility. most of the time PE is not considered in differ-ential diagnosis while evaluating such patients in emergency. Pulmonary embolism requires high clinical suspi-cion, based on validated scores and requires further multi-modality investigation to confirm or rule out disease. Key words: Acute Pulmonary Embolism, Bronchial Asthma, High Clinical Suspicion
Liquid Biopsy : An emerging concept for diagnosis and management of cancer
Authors:   Department of Pathology, Sri Devaraj Urs Medical Collage, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar -563101, Karnataka, R Dr. Kalyani
Published: February 2023

Tumour diagnosis is conventionally done by radiological findings and invasive surgical biopsy. Of late non-invasive technique where blood sample, urine and body fluids are used to extract circulating tumour cells (CTC) and genetic material for cancer diagnosis and treatment which is called as “Liquid Biopsy”.1,2 In this technique the liquid sample is used to isolate CTC, circulating tumour DNA (ctDNA), RNA, Exosomes and proteins which are shed by tumour cells into blood circulation, body fluids or urine in most of the cancers depending on the site of the can-cer. This technique enables non-invasive profiling of solid tumours, the results which can be comparable with that of tissue biopsy.3,4,5,6,7 As tissue biopsy is single biopsy, it gives only spatially and temporary snap shot of genetic makeup of cancer tissue unlike liquid biopsy, where samples can be taken at repeated intervals and it reveals the dynamic and heterogenei-ty of the cancer tissue.[8] Originally liquid biopsy was used to analyze CTC. At present it mainly analyzes ctDNA. However CTC and ctDNA are complementary technologies which can be used in parallel. As ctDNA is a potential surrogate for the entire tumour genome, it is many times referred as “Liquid Biopsy”.9,10 The different components of liquid biopsy are CTC, ctDNA, RNA, Exosomes, Proteins and Platelets.
Surveillance of healthcare associated infections at a tertiary care teaching hospital from 2014 to 2016: Prevalence, microbiological spectrum and antibiogram
Authors:   Assistant Professor, Department of Microbiology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar., N Savitha , D Anitha , Beena PM
Published: February 2023

Background: Healthcare-associated infections have emerged as a significant cause of mortality in the recent years. One of the major concerns in the prevalence of such infections is the development of multidrug-resistant microorganisms. Aim: The present surveillance study was conducted to assess the prevalence, microbiological spectrum, and antimicrobial susceptibility aminoof the microorganisms at a tertiary care hospital. Methods: The study was conducted between May 2014 and December 2016 including 466 patients (255 men and 211 women) diagnosed with healthcare-associated infections. Data related to sex, age, time of admission, type of surgery, and complication were collected. Samples of the pus, urine, and blood were collected and sent for isolation and characterization of microorganisms. Antimicrobial sensitivity was conducted by following the Clinical Laboratory Standards Institute (CLSI) guidelines. Data obtained were recorded in Microsoft Excel and analyzed using R 3.3.1; P < 0.05 indicative of significant differences. Result: Mean age of the patients was 41.01 ± 18.11 years. Prevalence results were highest in surgical site infec-tion (79.18%) and gram-negative organisms (80.92%) were the prevalent causes of infection. Escherichia coli (21.54%), Pseudomonas aeruginosa (15.76%), and Acinetobacter sp. (12.22%) were the predominant organ-isms with maximum sensitivity towards carbapenems, aminoglycosides, and cotrimoxazole, respectively. E. coli was the prevalent producer of AmpC and extended-spectrum beta-lactamases. Conclusion: Reduced sensitivity to the majority of antimicrobials has led to the prevalence of gram-negative organisms in the healthcare-associated infections. However, carbapenems and chloramphenicol along with aminoglycosides remain the effective broad-spectrum antimicrobials. Further studies are required strategies to minimize antibiotic resistance, which can lead to improvement in therapeutic methods. Keywords: Escherichia coli, Carbapenems, Surgical site infection, Lactamases
Depression among Elderly - An Unaddressed Emerging Burden. A Community Based Cross Sectional Study
Authors:   2nd Year Postgraduate, Department of Community Medicine, Sri Devaraj Urs Medical college, Sri Devaraj Urs Academy of Higher Education and Research, Kolar., V Bhoomika , T S Pradeep Kumar , C Muninarayana
Published: February 2023

Background: Growing old is an intrinsic phenomenon. Communicable diseases are under control and non-communicable diseases are increasing. Depression is a common mental health disorder in elderly. Depression can cause great suffering and impaired functioning in daily life. Aim: study are to find the prevalence and factors influencing depression among rural elderly study partici-pants. Methods: It is a Community based, Cross sectional analytical study design carried out for a period of 6 months among elderly persons aged 60 years and above residing in the rural field practice area of SDUMC, Kolar. Bed ridden participants, those with mental health issues were excluded. Data collected using pretested semi-structured questionnaire and Depression assessed by GDS-15 Chi-square applied to test association with p value significance defined lesser than 0.05. Results: Out of 286 study participants, 111(38.8 %) belonged to Keeloholali, 154(53.8%) were female partici-pants, 118(41.3%) were unemployed, 244(85.3%) were illiterates, 7.3% had diabetes, 11.5% had visual impair-ment, 121(42.3%) belonged to nuclear family and 195(68.2%) were married. 228(79.7%) of study participants had one or other type of depression. Conclusion: Depression among elderly is increasing and many times it is unaddressed. To better the quality of life and increase the life expectancy among elderly, early diagnosis of mental illness plays a crucial role. Key-words: Depression, elderly, risk factors
Effectiveness Of Video Assisted Teaching On Danger signs in New born Of Mothers Of Preterm Baby In A Selected Hospital Of Kolar
Authors:   Associate Professor, Sri Devaraj Urs College of Nursing, Tamaka, Kolar., Subhashini Lavanya , Sarin Jyoti , Shankar Ravi
Published: February 2023

Introduction: Preterm birth is defined as childbirth occurring at less than 37 completed weeks. Educational interventions for mothers are commonly viewed as an important strategy to promote their knowledge and practice of childcare skills. Aim: To assess and compare the effectiveness of Video Assisted Teaching on Danger signs in newbornof moth-ers of Preterm baby in both control and experimental group. Materials and Methods: Quasiexperimental research design with two group pretest posttest design was used for the study. The study was conducted in Neonatal Intensive Care Unit (NICU) of RL Jallapa Hospital and Re-search centre at Kolar. Total of 150 mothers, 75 each in experimental and control group were selected by pur-posive sampling technique. Results: The overall mean pre test knowledge score (5.62±2.8) in experimental group was significantly higher (t=2.53; p<.01) than that of pre test knowledge score (4.69±2.01) in control group. The overall mean post test knowledge score (15.71±1.26) in experimental group was significantly higher (t=0.14; p<.0001) than that of post test knowledge score (5.04±1.96) in control group. Conclusion: Video assisted teaching had enhanced the knowledge of mothers regarding danger signs of new-born. The study highlights the importance of educational support to mothers of preterm baby. Key words: Danger signs, Preterm baby, Video assisted teaching and Knowledge
Massive Transfusion Protocol: Role of maximum Surgical Blood Ordering Schedule
Authors:   Professor, Department of Pathology, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar., Das Subhashis
Published: February 2023

Preoperative placement of blood requests frequently overshoots the actual need resulting in unnecessary cross matching, which can be reduced by formulating maximum surgical blood ordering schedule (MSBOS). It is a table of elective surgical procedures, which lists the number of units of blood routinely cross-matched pre-operatively. MSBOS based on the past blood utilization records for different surgeries and keeping patients varia-bles in consideration wherever required would provide an efficient way of blood utilization and appropriate management of blood bank resources. The objective of this review throw eight on is to the blood utilization in various surgeries that can result in unnecessary cross-matching, wastage of blood bank resources, and financial losses to the patients could be reduced. Key words: Blood requests, crossmatch, polytrauma, Blood transfusion
Peran Latar Belakang Keluarga Terhadap Keberlangsungan Usaha dan Kesejahteraan Pengrajin Perak di Kabupaten Gianyar
Authors: Pratiwi I Gusti Ayu Made Agung Mas Andriani , Kusmawan I Made Hary
Published: February 2023

The silver industry in Gianyar Regency is a business that has been carried out for generations, so it is not surprising that Gianyar Regency is known as a center for silver crafts. However, currently the condition of silver handicraft SMEs is in a stagnant condition and even tends to decline, especially with the Covid-19 pandemic so that it can have an impact on business continuity and the welfare of craftsmen. The purpose of this study was to examine the effect of family background on business continuity and the welfare of silver craftsmen in Gianyar Regency. The population in this study is 235 silver handicraft IKM. The research sample was determined using a purposive sampling method resulting in a total sample of 95 silver handicraft IKM. This study uses descriptive analysis techniques and quantitative analysis techniques with structural equation models or Structural Equation Modeling (SEM), especially Partial Least Square (PLS) with an analytical tool, namely SmartPLS. The results showed that (1) family background had a significant positive direct effect on the sustainability of the silver craftsmen's business in Gianyar Regency; (2) Family background and business continuity have a significant positive direct effect on the welfare of silver craftsmen in Gianyar Regency; and (3) business continuity mediating the influence of family background on the welfare of silver craftsmen in Gianyar Regency.
Game Edukasi Metamorfosis Hewan Dengan Augmented Reality Berbasis Android
Authors: Bonanza Muhammad Jodie , Fathurriza Ari , Sudiatmika I Putu Gede Abdi , Rahardian Rifky Lana
Published: February 2023

There are several problems found in elementary school learning. One of them is learning media. Currently, there are many types of learning media, some are digital-based such as learning media using audio media, multimedia computers, and there are also conventional learning that still uses books, pictures in the teaching and learning process such as metamorphosis learning which still uses books in the teaching process. To improve the learning process at SD No. 3 Ungasan in grades 3,4, and 5 in the field of natural science, an educational game of animal metamorphosis was made with android-based augmented reality as a learning medium. The purpose of this research is to build an Android-based augmented reality animal metamorphosis educational game to help elementary school students and teachers. This educational game is built in the C# programming language using the Unity Engine. The method used in making this game is Multimedia Development Life Cycle (MDLC). The test system used is blackbox testing, where the results of system testing conclude that the system is in line with expectations. Based on the results of user testing, this educational game got a 100% increase in satisfaction from 17 responses consisting of 2 teachers and 15 students.
Hakekat Filsafat Hukum dalam Pembangunan Hukum Nasional
Authors: Pratiwi Ida Ayu Windhari Kusuma , Pitriyantini Putu Eka , Suardana I Wayan
Published: February 2023

Law is a science, although law has its own characteristics because the object of study is quite broad. Legal science as a science also undergoes a process. As a science that is Sui Generis, it can be said that law has a fairly broad field of study consisting of three layers, namely; legal dogmatic layers, legal theory, and legal philosophy, and the three layers of legal science have benefits for the development of national law. This study has two problem formulations: What is the role of legal philosophy in the development of the national legal system and how is the implementation of legal philosophy in solving legal problems. The method used in this study is the normative legal methodology, which examines legal issues from the perspective of norms. The role of philosophy of law in the development of the national legal system is the basis for the level of abstraction of theoretical reflection whose level of abstractness is at the highest level and therefore permeates all forms of theoretical legal exploitation and practical legal exploitation. The implementation of legal philosophy in solving legal problems is to provide a basis for every legal decision which is used as a reference for decision makers to solve legal problems in order to achieve justice in society and legal certainty. An example is the event of a norm conflict between Article 24 A of the 1945 Constitution and Article 251 of Law Number 23 of 2014 concerning Regional Government
Governance Strategy Juridical Rural Creative Economy Respond To Competitive Global Competition
Authors: Adnyani Ni Ketut Sari , Sudiatmaka Ketut , Landrawan I Wayan
Published: February 2023

This research is motivated because of the importance of legal protection also serves as protection for the governance of the rural economy, among others, can we review the various forms of business startups together or independent creative such as from several sectors among others include: crafts produced by businesses traditional craft "weaving" typical Bali, whether generated by an individual or collective basis. Activities of corporate governance in achieving the goal must always be done with the provisions of applicable law. In case this is not rare in the field that many business activities that have not been able to carry out the legal relationship for the corporate governance businesses without first consulting with legal teams, and business people never know when the legal relationship occurs. The lack of knowledge and understanding of the technical legal advice resulted in the governance of rural creative economy also occur in governance typical handicraft industry Endek Klungkung be difficult to develop and the potential of the craft. Methodologically, this study is the development of research in the engineering building public policy on rural economic governance creative competitive in the face of global competition. This research, that research is a digger / primary data collection tool.
Research, difficulties for businesses in the countryside in conducting the governance of creative economic development, that despite constraints in the production, management, marketing, collaboration and licensing are also difficulties in connection with public knowledge of related legal actions that could be proved from the people who do not know procedures and in the management of copyright as a form of lack of legal awareness of the local community. Strategy juridical taken by the manager of the creative economy is rustic in to protect against the type of business and deliver services to consumers, the community's knowledge related to legal remedies that can be done to protect the product of the creative economy to rural areas of action flagiasi and coordinate with Disperindag related to administrative registration of copyright which are owned.
Analisis Pengaruh Marketing Influencer Tiktok Terhadap Keinginan Pembelian Pada Pengguna Aplikasi Tiktok
Authors: Ariasih Made Putri , Putra I Putu Dharmawan Suryagita Susila
Published: February 2023

The TikTok application contains various videos created by content creators. Content creators whose video content is watched a lot and has many followers are called influencers. Influencers with a large audience usually open services to advertise a product, with influencers the advertised product will be noticed by many people, so that people watching have an intention to buy the advertised product. The purpose of this study was to analyze the influence of the tiktok marketing influencer on the emergence of purchase intentions from users of the tiktok. This study uses a qualitative research approach. The data collection technique used in this study uses data collection techniques on various literature, as well as various reports related to research variables. This study uses data collected by observation techniques on the TikTok. Data was also collected using interview techniques, by interviewing a company that had used the services of an influencer, and interviewing users of the TikTok. This study obtained the results, the first company uses the services of influencers to introduce their products and generate purchase intentions. Second, consumers in making purchasing decisions will seek information about the products they will buy through influencers. Third, video content created by influencers can raise consumers' purchase intention.