bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S5 from Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity
Authors: Kwong Brandon , Gai S. Annie , Elkhader Jamal , Wittrup K. Dane , Irvine Darrell J.
Published: March 2023

Supplementary Figure S5 PDF file 49K, Therapeutic efficacy of Lip-�CD137 + Lip-IL-2Fc i.t. therapy against s.c. A20 and TC-1 tumors
Supplementary Figure S4 from Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity
Authors: Kwong Brandon , Gai S. Annie , Elkhader Jamal , Wittrup K. Dane , Irvine Darrell J.
Published: March 2023

Supplementary Figure S4 PDF file 42K, Therapeutic efficacy of Lip-�CD137 or Lip-IL-2Fc as monotherapy
Supplementary Figure S2 from Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity
Authors: Kwong Brandon , Gai S. Annie , Elkhader Jamal , Wittrup K. Dane , Irvine Darrell J.
Published: March 2023

Supplementary Figure S2 PDF file 828K, Accumulation of Lip-�CD137 + Lip-IL-2Fc in proximal tumor-draining LN
Supplementary Table 1 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening
Authors: Tyner Jeffrey W. , Yang Wayne F. , Bankhead Armand , Fan Guang , Fletcher Luke B. , Bryant Jade , Glover Jason M. , Chang Bill H. , Spurgeon Stephen E. , Fleming William H. , Kovacsovics Tibor , Gotlib Jason R. , Oh Stephen T. , Deininger Michael W. , Zwaan Christian Michel , Den Boer Monique L. , van den Heuvel-Eibrink Marry M. , O'Hare Thomas , Druker Brian J. , Loriaux Marc M.
Published: March 2023

XLS file - 114K, Kinase Inhibitor Gene Targets
Supplementary Figure Legends from TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase
Authors: Wang Xiaoping , Saso Hitomi , Iwamoto Takayuki , Xia Weiya , Gong Yun , Pusztai Lajos , Woodward Wendy A. , Reuben James M. , Warner Steven L. , Bearss David J. , Hortobagyi Gabriel N. , Hung Mien-Chie , Ueno Naoto T.
Published: March 2023

PDF file, 80K.
Supplementary Table 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Authors: Zhang Lei , Pickard Karen , Jenei Veronika , Bullock Marc D. , Bruce Amanda , Mitter Richard , Kelly Gavin , Paraskeva Christos , Strefford John , Primrose John , Thomas Gareth J. , Packham Graham , Mirnezami Alex H.
Published: March 2023

PDF file, 102K, Univariate analysis table.
Supplementary Figure 6 from VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis
Authors: Alitalo Annamari K. , Proulx Steven T. , Karaman Sinem , Aebischer David , Martino Stefania , Jost Manuela , Schneider Nicole , Bry Maija , Detmar Michael
Published: March 2023

PDF - 1898K, Expression of neuropilins in skin and tumors of wild-type mice.
Supplementary Figure from A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer
Authors: Deshpande Raamesh , Asiedu Michael K. , Klebig Mitchell , Sutor Shari , Kuzmin Elena , Nelson Justin , Piotrowski Jeff , Ho Shin Seung , Yoshida Minoru , Costanzo Michael , Boone Charles , Wigle Dennis A. , Myers Chad L.
Published: March 2023

PDF file, 464K, Genetic interaction test results for all interactions tested for this study.
Supplementary Methods from miR145 Targets the SOX9/ADAM17 Axis to Inhibit Tumor-Initiating Cells and IL-6–Mediated Paracrine Effects in Head and Neck Cancer
Authors: Yu Cheng-Chia , Tsai Lo-Lin , Wang Mong-Lien , Yu Chuan-Hang , Lo Wen-Liang , Chang Yun-Ching , Chiou Guang-Yuh , Chou Ming-Yung , Chiou Shih-Hwa
Published: March 2023

PDF file - 197K
Supplementary Figure 1 - 9 from Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance
Authors: Dai Haiming , Ding Husheng , Meng X. Wei , Lee Sun-Hee , Schneider Paula A. , Kaufmann Scott H.
Published: March 2023

PDF file - 10382K, Time-of-flight mass spectrometry of phosphorylated Bcl-2 (S1); Thr69, Thr74 and Ser87 mutations increase affinity of Bcl-2 for Bak (S2); Ser70 mutations alter Bcl-2 conformation (S3); Effect of various Bcl-2 constructs on apoptosis induction by EGFP-BimEL and EGFP-Bak (S4); Bcl-2 Ser70 modifications increase MEF cell resistance to Bak-induced apoptosis (S5); Effect RNA interference for Bcl-2, Bcl-xL and Mcl-1 on induction of apoptosis by paclitaxel (S6); Effects of a second set of shRNAs targeting Bcl-2, Bcl-xL or Mcl-1 on paclitaxel-induced apoptosis (S7); Effect of navitoclax on paclitaxel-induced apoptosis in additional ovarian cancer cell lines (S8); Comparison of ability of ABT-199 and navitoclax to sensitize cells to paclitaxel (S9).
Supplementary Figure 3 from Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer
Authors: Shiota Masaki , Bishop Jennifer L. , Nip Ka Mun , Zardan Anousheh , Takeuchi Ario , Cordonnier Thomas , Beraldi Eliana , Bazov Jenny , Fazli Ladan , Chi Kim , Gleave Martin , Zoubeidi Amina
Published: March 2023

PDF file - 70K, Hsp27 knockdown reduces cell invasion and MMP activity.
Supplementary Table from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 67K, IC50 obtained for different anti-S-3B siRNA treated cells after exposure to different drugs.
Supplementary Figure 8 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 126K, Representative western blots corresponding to Figure 5c.
Supplementary Figure 7 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 167K, S-3B expression increased with resistance acquisition.
Supplementary Figure 3 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 233K, Data completing Figure 3.
Supplementary Figure 5 from DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer
Authors: Cao Jianzhong , Song Yongmei , Bi Nan , Shen Jie , Liu Wenyang , Fan Jing , Sun Guogui , Tong Tong , He Jie , Shi Yuankai , Zhang Xun , Lu Ning , He Yinghua , Zhang Hongyu , Ma Kelong , Luo Xiaoying , Lv Lei , Deng Hui , Cheng Jing , Zhu Jingde , Wang Luhua , Zhan Qimin
Published: March 2023

PDF file - 98K, The PLK1 protein levels in FFEF specimens in miR-886-3p high and low expression groups of SCLC samples (13 each).
Supplementary Figure 1 from Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Authors: Végran Frédérique , Mary Romain , Gibeaud Anne , Mirjolet Céline , Collin Bertrand , Oudot Alexandra , Charon-Barra Céline , Arnould Laurent , Lizard-Nacol Sarab , Boidot Romain
Published: March 2023

PDF file, 314K, Survivin isoforms expression in cell lines.
Supplementary Methods from Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma
Authors: Hsu Shih-Hsien , Wang Li-Ting , Lee King-Teh , Chen Yao-Li , Liu Kwei-Yan , Suen Jau-Ling , Chai Chee-Yin , Wang Shen-Nien
Published: March 2023

PDF file - 198K, Description of supplemental methods includes Western Blot and Immunohistochemical Staining Analysis, Luciferase Reporter Assays and ChIP Assays, as well as Anchorage-independent growth assays and Real Time PCR data
Supplementary Figure 5 from Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma
Authors: Hsu Shih-Hsien , Wang Li-Ting , Lee King-Teh , Chen Yao-Li , Liu Kwei-Yan , Suen Jau-Ling , Chai Chee-Yin , Wang Shen-Nien
Published: March 2023

PDF file - 53K, Apoptotic signalings were detected in Isx shRNAi Hep G2 cells.
Supplementary Table 7 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program
Authors: Charafe-Jauffret Emmanuelle , Ginestier Christophe , Bertucci François , Cabaud Olivier , Wicinski Julien , Finetti Pascal , Josselin Emmanuelle , Adelaide José , Nguyen Tien-Tuan , Monville Florence , Jacquemier Jocelyne , Thomassin-Piana Jeanne , Pinna Guillaume , Jalaguier Aurélie , Lambaudie Eric , Houvenaeghel Gilles , Xerri Luc , Harel-Bellan Annick , Chaffanet Max , Viens Patrice , Birnbaum Daniel
Published: March 2023

Table SVII. Enrichment test between stemness GES and our BCSC-GES
Supplementary Figure 4 from Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma
Authors: Hsu Shih-Hsien , Wang Li-Ting , Lee King-Teh , Chen Yao-Li , Liu Kwei-Yan , Suen Jau-Ling , Chai Chee-Yin , Wang Shen-Nien
Published: March 2023

PDF file - 40K, The quantitative statistical analysis of cell cycle regulators in Isx shRNAi cells.
Supplementary Table 6 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program
Authors: Charafe-Jauffret Emmanuelle , Ginestier Christophe , Bertucci François , Cabaud Olivier , Wicinski Julien , Finetti Pascal , Josselin Emmanuelle , Adelaide José , Nguyen Tien-Tuan , Monville Florence , Jacquemier Jocelyne , Thomassin-Piana Jeanne , Pinna Guillaume , Jalaguier Aurélie , Lambaudie Eric , Houvenaeghel Gilles , Xerri Luc , Harel-Bellan Annick , Chaffanet Max , Viens Patrice , Birnbaum Daniel
Published: March 2023

Table SVI: Correlation between histoclinical and molecular parameters and our BCSC-GES in 2609 patients from public datasets
Supplementary Figure 2 from Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma
Authors: Hsu Shih-Hsien , Wang Li-Ting , Lee King-Teh , Chen Yao-Li , Liu Kwei-Yan , Suen Jau-Ling , Chai Chee-Yin , Wang Shen-Nien
Published: March 2023

PDF file - 160K, Isx protein expression in HCC patient showed high expression correlation with cyclin D1 and Ki67 in HCC tumor cells.
Supplementary Table from ANTXR1, a Stem Cell-Enriched Functional Biomarker, Connects Collagen Signaling to Cancer Stem-like Cells and Metastasis in Breast Cancer
Authors: Chen Daohong , Bhat-Nakshatri Poornima , Goswami Chirayu , Badve Sunil , Nakshatri Harikrishna
Published: March 2023

PDF file, 4845K, Results of microarray analysis of control and ANTXR1 knockdown cells.
Supplementary Figures 1 - 14 from ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program
Authors: Charafe-Jauffret Emmanuelle , Ginestier Christophe , Bertucci François , Cabaud Olivier , Wicinski Julien , Finetti Pascal , Josselin Emmanuelle , Adelaide José , Nguyen Tien-Tuan , Monville Florence , Jacquemier Jocelyne , Thomassin-Piana Jeanne , Pinna Guillaume , Jalaguier Aurélie , Lambaudie Eric , Houvenaeghel Gilles , Xerri Luc , Harel-Bellan Annick , Chaffanet Max , Viens Patrice , Birnbaum Daniel
Published: March 2023

PDF file - 3065K, Figure S1. Average delay of growth of PDXs among passages (up to P5). Figure S2. DNA copy number variations found in the original primary tumors are well maintained in PDXs. Figure S3. Example of stromal dilution in parental primary tumor CRCM184 PT compared to paired CRCM 184 X. Figure S4. ALDEFLUOR phenotype of our 20 PDX models. Figure S5. Outgrowth kinetic of each sorted cell population isolated from three PDXs and injected in limited dilutions in fat pads of NSG mice. Figure S6. Univariate and multivariate analysis identified primary tumor engrafment as independent parameter associated with metastasis-free survival (MFS) in the series of 74 patients. Figure S7. Identification of parameters that predict successful engraftment. Figure S8. Global gene expression profiling of 53 PDXs. Figure S9. Supervised analyses of aCGH data comparing copy number variations in 17 paired primary tumors/PDXs. Figure S10. Representative network of genes isolated from the BCSC-GES and involved in DNA damage repair. Figure S11. Representative network of genes isolated from the BCSC-GES and involved in cell cycle control. Figure S12. The ?common? stem cell core transcriptional program (CE-4SC) is associated with clinical outcome. Figure S13. Functional validation of the CE-4SC in two different breast cancer cell lines (BCLs). Figure S14. Knock-down of genes from the CE-4SC affect tumorsphere-forming efficiency (SFE) in S68 BCL.
Supplementary Figure 3 from NF-κB Regulates Radioresistance Mediated By β1-Integrin in Three-Dimensional Culture of Breast Cancer Cells
Authors: Ahmed Kazi Mokim , Zhang Hui , Park Catherine C.
Published: March 2023

PDF File - 1849K, Non-malignant S1 acini was not affected by inhibition of NF-�B in 3D lrECM culture.
Supplementary Figure 1 from NF-κB Regulates Radioresistance Mediated By β1-Integrin in Three-Dimensional Culture of Breast Cancer Cells
Authors: Ahmed Kazi Mokim , Zhang Hui , Park Catherine C.
Published: March 2023

PDF File - 1455K, Radiation-induced phospho and total �1-integrin and focal adhesion kinase (FAK) expressions were downregulated by NF-�B inhibitor.
Supplementary Table from Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression
Authors: Regan Anderson Tarah M. , Peacock Danielle L. , Daniel Andrea R. , Hubbard Gregory K. , Lofgren Kristopher A. , Girard Brian J. , Schörg Alexandra , Hoogewijs David , Wenger Roland H. , Seagroves Tiffany N. , Lange Carol A.
Published: March 2023

PDF file, 5252K, Table detailing patient information from HCI tumor samples used.
Supplementary Figure Legend from Hedgehog Signaling Alters Reliance on EGF Receptor Signaling and Mediates Anti-EGFR Therapeutic Resistance in Head and Neck Cancer
Authors: Keysar Stephen B. , Le Phuong N. , Anderson Ryan T. , Morton J. Jason , Bowles Daniel W. , Paylor Jeramiah J. , Vogler Brian W. , Thorburn Jackie , Fernandez Pamela , Glogowska Magdalena J. , Takimoto Sarah M. , Sehrt Daniel B. , Gan Gregory N. , Eagles-Soukup Justin R. , Serracino Hilary , Hirsch Fred R. , Lucia M. Scott , Thorburn Andrew , Song John I. , Wang Xiao-Jing , Jimeno Antonio
Published: March 2023

PDF file - 113K
Supplementary Table 3 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 180K, HoxA10 leukemia targets in Glioma NS cells
Supplementary Figures from Mammary Tumor Formation and Metastasis Evoked by a HER2 Splice Variant
Authors: Alajati Abdullah , Sausgruber Nina , Aceto Nicola , Duss Stephan , Sarret Sophie , Voshol Hans , Bonenfant Debora , Bentires-Alj Mohamed
Published: March 2023

PDF file, 246K, Quantification of WT-HER2 or Delta-HER2 and their effect on wound healing (S1); Low level expression of Delta-HER2 induces P-ERK and P-AKT, increases migration and induces mammary tumors (S2); Effect of WT-HER2 and Delta-HER2 expression on MCF10A 3D cultures (S3); Delta-HER2 overexpressing tumors are sensitive to trastuzumab (S4).
Supplementary Figure Legends 1-10 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 101K
Supplementary Figure 9 from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
Authors: Cortot Alexis B. , Repellin Claire E. , Shimamura Takeshi , Capelletti Marzia , Zejnullahu Kreshnik , Ercan Dalia , Christensen James G. , Wong Kwok-Kin , Gray Nathanael S. , Jänne Pasi A.
Published: March 2023

PDF file - 415K, Effect of EGFR inhibitors (PF299804 or WZ4002) alone, BMS 53924 alone, CI-1040 alone or the combination of all 3 agents on cell signaling in the PFR3 + and WZR4 +
Supplementary Figure 7 from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
Authors: Cortot Alexis B. , Repellin Claire E. , Shimamura Takeshi , Capelletti Marzia , Zejnullahu Kreshnik , Ercan Dalia , Christensen James G. , Wong Kwok-Kin , Gray Nathanael S. , Jänne Pasi A.
Published: March 2023

PDF file - 34K, PFR5 and PFR5+ cells grow in a similar fashion
Supplementary Figure 7 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 115K, HOXA10 targets leukemic genes
Supplementary Figure 6 from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
Authors: Cortot Alexis B. , Repellin Claire E. , Shimamura Takeshi , Capelletti Marzia , Zejnullahu Kreshnik , Ercan Dalia , Christensen James G. , Wong Kwok-Kin , Gray Nathanael S. , Jänne Pasi A.
Published: March 2023

PDF file - 64K, IGF1R and pIGFR1R levels are similar in the PFR3 and PFR3+, and WZR4 and WZR4+ cells
Supplementary Figure 3 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells
Authors: Gallo Marco , Ho Jenny , Coutinho Fiona J. , Vanner Robert , Lee Lilian , Head Renee , Ling Erick K. M. , Clarke Ian D. , Dirks Peter B.
Published: March 2023

PDF file - 61K, HoxA10 knockdown
Supplementary Figure Legends from C-RAF Mutations Confer Resistance to RAF Inhibitors
Authors: Antony Rajee , Emery Caroline M. , Sawyer Allison M. , Garraway Levi A.
Published: March 2023

Supplementary Figure Legends - PDF file 92K, Supplementary figure legends
Supplementary Figure 4 from Microtubule-Associated Histone Deacetylase 6 Supports the Calcium Store Sensor STIM1 in Mediating Malignant Cell Behaviors
Authors: Chen Ying-Ting , Chen Yih-Fung , Chiu Wen-Tai , Liu Kuan-Yu , Liu Yu-Lin , Chang Jang-Yang , Chang Hsien-Chang , Shen Meng-Ru
Published: March 2023

PDF file - 738K, HDAC6 inhibitor, tubastatin-A, blocks STIM1 membrane trafficking.
Supplementary Figure 1 from Microtubule-Associated Histone Deacetylase 6 Supports the Calcium Store Sensor STIM1 in Mediating Malignant Cell Behaviors
Authors: Chen Ying-Ting , Chen Yih-Fung , Chiu Wen-Tai , Liu Kuan-Yu , Liu Yu-Lin , Chang Jang-Yang , Chang Hsien-Chang , Shen Meng-Ru
Published: March 2023

PDF file - 836K, The integrity of microtubules is necessary for STIM1 membrane trafficking and the interaction with Orai1.
Supplementary Table 1 from miRNA-95 Mediates Radioresistance in Tumors by Targeting the Sphingolipid Phosphatase SGPP1
Authors: Huang Xiaoyong , Taeb Samira , Jahangiri Sahar , Emmenegger Urban , Tran Elisa , Bruce Jeff , Mesci Aruz , Korpela Elina , Vesprini Danny , Wong C. Shun , Bristow Robert G. , Liu Fei-Fei , Liu Stanley K.
Published: March 2023

PDF file - 3340K, miR that are increased in PC3 rad res cells compared to PC3 control cells.
Supplementary Table 3 from Gankyrin Activates IL-8 to Promote Hepatic Metastasis of Colorectal Cancer
Authors: Bai Zhaofang , Tai Yanhong , Li Weihua , Zhen Cheng , Gu Weiting , Jian Zhao , Wang Qianyi , Lin Jieru E. , Zhao Qing , Gong Weili , Liang Bing , Wang Chenguang , Zhou Tao
Published: March 2023

PDF file - 52K, The sequence of primers used for real-time PCR.
Supplementary Figure 2 from Gankyrin Activates IL-8 to Promote Hepatic Metastasis of Colorectal Cancer
Authors: Bai Zhaofang , Tai Yanhong , Li Weihua , Zhen Cheng , Gu Weiting , Jian Zhao , Wang Qianyi , Lin Jieru E. , Zhao Qing , Gong Weili , Liang Bing , Wang Chenguang , Zhou Tao
Published: March 2023

PDF file - 105K, Gankyrin is required for cell migration.
Supplementary Table 2 from G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic
Authors: Hsu Danielle M. , Agarwal Saurabh , Benham Ashley , Coarfa Cristian , Trahan Denae N. , Chen Zaowen , Stowers Paris N. , Courtney Amy N. , Lakoma Anna , Barbieri Eveline , Metelitsa Leonid S. , Gunaratne Preethi , Kim Eugene S. , Shohet Jason M.
Published: March 2023

PDF file - 41K, QPCR validation of genes from the CD114+ and CD114- cell populations.
Supplementary Table 1 from G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic
Authors: Hsu Danielle M. , Agarwal Saurabh , Benham Ashley , Coarfa Cristian , Trahan Denae N. , Chen Zaowen , Stowers Paris N. , Courtney Amy N. , Lakoma Anna , Barbieri Eveline , Metelitsa Leonid S. , Gunaratne Preethi , Kim Eugene S. , Shohet Jason M.
Published: March 2023

PDF file - 54K, Analysis of xenograft tumors derived from CD114+/CD114- mixing studies.
Supplementary Legends from Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein
Authors: Dua Pooja , Kang Hye Suk , Hong Seung-Mo , Tsao Ming-Sound , Kim Soyoun , Lee Dong-ki
Published: March 2023

Supplementary Legends PDF file -51K, Supplementary Figure Legends
Supplementary Methods, Figure Legend from Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells
Authors: Khanna Anchit , Kauko Otto , Böckelman Camilla , Laine Anni , Schreck Ilona , Partanen Johanna I. , Szwajda Agnieszka , Bormann Stefanie , Bilgen Turker , Helenius Merja , Pokharel Yuba R. , Pimanda John , Russel Mike R. , Haglund Caj , Cole Kristina A. , Klefström Juha , Aittokallio Tero , Weiss Carsten , Ristimäki Ari , Visakorpi Tapio , Westermarck Jukka
Published: March 2023

PDF file - 205K
Supplementary Figure 2 from Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer
Authors: Park Dongkyoo , Magis Andrew T. , Li Rui , Owonikoko Taofeek K. , Sica Gabriel L. , Sun Shi-Yong , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Deng Xingming
Published: March 2023

PDF file, 55K, Depletion of Bcl-XL by RNAi reduces sensitivity of lung cancer cells to BXIs.
Supplementary Table 4 from YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway
Authors: Pikor Larissa A. , Lockwood William W. , Thu Kelsie L. , Vucic Emily A. , Chari Raj , Gazdar Adi F. , Lam Stephen , Lam Wan L.
Published: March 2023

XLSX file - 12K, Datasets used for analysis of YEATS4 copy number and expression.
Supplementary Table 3 from YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway
Authors: Pikor Larissa A. , Lockwood William W. , Thu Kelsie L. , Vucic Emily A. , Chari Raj , Gazdar Adi F. , Lam Stephen , Lam Wan L.
Published: March 2023

XLSX file - 9K, Gene list for Ingenuity Pathway Analysis.
Supplementary Table 1 from YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway
Authors: Pikor Larissa A. , Lockwood William W. , Thu Kelsie L. , Vucic Emily A. , Chari Raj , Gazdar Adi F. , Lam Stephen , Lam Wan L.
Published: March 2023

XLSX file - 11K, Candidate genes within the minimally amplified region of 12q15.
Supplementary Figure 5 from Loss of miR-204 Expression Enhances Glioma Migration and Stem Cell-like Phenotype
Authors: Ying Zhe , Li Yun , Wu Jueheng , Zhu Xun , Yang Yi , Tian Han , Li Wei , Hu Bo , Cheng Shi-Yuan , Li Mengfeng
Published: March 2023

PDF file - 22K, The effect of de-metylation agent on the expression of SOX4 and EphB2 in glioma cells.
Supplementary Figure 4 from Loss of miR-204 Expression Enhances Glioma Migration and Stem Cell-like Phenotype
Authors: Ying Zhe , Li Yun , Wu Jueheng , Zhu Xun , Yang Yi , Tian Han , Li Wei , Hu Bo , Cheng Shi-Yuan , Li Mengfeng
Published: March 2023

PDF file - 226K, Methylation status of TRPM3 promoter CpG island in glioma specimens.
Supplementary Figure Legends from CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1
Authors: Kim Jae-Sung , Kim Eun Ju , Oh Jeong Su , Park In-Chul , Hwang Sang-Gu
Published: March 2023

PDF file, 146K.
Supplementary Figure 1A from CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1
Authors: Kim Jae-Sung , Kim Eun Ju , Oh Jeong Su , Park In-Chul , Hwang Sang-Gu
Published: March 2023

PDF file, 656K, Immunohistochemical analysis of CIP2A and Plk1 expression in various human cancer specimens.
Supplementary Methods from miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non–Small Cell Lung Cancer
Authors: Cai Junchao , Fang Lishan , Huang Yongbo , Li Rong , Yuan Jie , Yang Yi , Zhu Xun , Chen Baixue , Wu Jueheng , Li Mengfeng
Published: March 2023

PDF file, 107K, Includes plasmids, viral production, transfection methods, and luciferase, qPCR, ELISA, MTT, Colony formation, Anchorage-independent growth, RIP, ChIP, HUVEC tube formation, CAM, and IHC assays.
Supplementary Methods, Figure Legend from In Vivo MAPK Reporting Reveals the Heterogeneity in Tumoral Selection of Resistance to RAF Inhibitors
Authors: Basile Kevin J. , Abel Ethan V. , Dadpey Neda , Hartsough Edward J. , Fortina Paolo , Aplin Andrew E.
Published: March 2023

PDF file - 72K
Supplementary Figures 1-4 from Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment
Authors: Isaacs John T. , Antony Lizamma , Dalrymple Susan L. , Brennen W. Nathaniel , Gerber Stephanie , Hammers Hans , Wissing Michel , Kachhap Sushant , Luo Jun , Xing Li , Björk Per , Olsson Anders , Björk Anders , Leanderson Tomas
Published: March 2023

PDF file - 1.2MB, Supplemental Figure 1. TasQ does not inhibit total HDAC enzymatic activity in HUVEC, LNCaP, or CWR22-Rv1 cells. Supplemental Figure 2. A. HDAC4 m-RNA expression in normal vs. metastatic prostate cancer tissues. B.Cytoplasmic vs. nuclear expression of HDAC4, beta-actin, and H3-histone protein in normal (i.e., PrEC) vs. prostate cancer cell lines. Supplemental Figure 3. A. Recombinant human HDAC4 in which the C669 and H675 in the ZRD are mutated to alanine preventing formation of the active conformation retains high affinity binding for TasQ as determined by surface plasmon resonance. B. A series of specific and non-specific HDAC4 shRNA lentiviral constructs were tested for their ability to down regulate HDAC4 in LNCaP cells. C. HDAC4 shRNA2 knock-down LNCaP cells are also non-tumorigenic in mice. D. Histology 56 days post inoculation of HDAC4 shRNA2 knock-down LNCaP cells. E. Histology 56 days post inoculation of shRNA2 knock down LNCaP cells which have had restoration of HDAC4 expression (i.e., arrows denote mitotic cells). Supplemental figure 4. TasQ inhibits the LDH-A protein expression under both normoxic and hypoxic conditions. B. TasQ inhibits HIF-1 dependent transcription induced by hypoxia
Supplementary Figure Legends 1-4 from Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment
Authors: Isaacs John T. , Antony Lizamma , Dalrymple Susan L. , Brennen W. Nathaniel , Gerber Stephanie , Hammers Hans , Wissing Michel , Kachhap Sushant , Luo Jun , Xing Li , Björk Per , Olsson Anders , Björk Anders , Leanderson Tomas
Published: March 2023

PDF file - 65K
Supplementary Figure 7 from BCR-ABL–Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients
Authors: Levescot Anaïs , Flamant Stéphane , Basbous Sara , Jacomet Florence , Féraud Olivier , Anne Bourgeois Elvire , Bonnet Marie-Laure , Giraud Christine , Roy Lydia , Barra Anne , Chomel Jean-Claude , Turhan Ali , Guilhot François , Girard Jean-Philippe , Gombert Jean-Marc , Herbelin André
Published: March 2023

PDF file - 208KB, Xenotransplant experiments in immunodeficient NOG mice (A); Mouse model of CML-like induced syndrome (B-C).
Supplementary Figures 1-4 from Hepatocarcinogenesis Driven by GSNOR Deficiency Is Prevented by iNOS Inhibition
Authors: Tang Chi-Hui , Wei Wei , Hanes Martha A. , Liu Limin
Published: March 2023

PDF File - 91K, Lack of effect of 1400W on HCC cell growth.
Supplementary Table 1 from Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee
Authors: Ittmann Michael , Huang Jiaoti , Radaelli Enrico , Martin Philip , Signoretti Sabina , Sullivan Ruth , Simons Brian W. , Ward Jerrold M. , Robinson Brian D. , Chu Gerald C. , Loda Massimo , Thomas George , Borowsky Alexander , Cardiff Robert D.
Published: March 2023

PDF file - 38K
Supplementary Figure 7 from Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-α Status
Authors: Harrison Hannah , Rogerson Lynsey , Gregson Hannah J. , Brennan Keith R. , Clarke Robert B. , Landberg Göran
Published: March 2023

PDF file - 11491K, Automated scoring of HIF1. Controls analysis for tumour growth rate/cell number extracted vs MFU
Supplementary Figure 4 from Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee
Authors: Ittmann Michael , Huang Jiaoti , Radaelli Enrico , Martin Philip , Signoretti Sabina , Sullivan Ruth , Simons Brian W. , Ward Jerrold M. , Robinson Brian D. , Chu Gerald C. , Loda Massimo , Thomas George , Borowsky Alexander , Cardiff Robert D.
Published: March 2023

PDF file - 17933K, Supplementary Figure 4. Neuroendocrine carcinoma.
Supplementary Figure 5 from Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-α Status
Authors: Harrison Hannah , Rogerson Lynsey , Gregson Hannah J. , Brennan Keith R. , Clarke Robert B. , Landberg Göran
Published: March 2023

PDF file - 4997K, Adherent clonogenic culture method and valifation
Supplementary Figure 3 from Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee
Authors: Ittmann Michael , Huang Jiaoti , Radaelli Enrico , Martin Philip , Signoretti Sabina , Sullivan Ruth , Simons Brian W. , Ward Jerrold M. , Robinson Brian D. , Chu Gerald C. , Loda Massimo , Thomas George , Borowsky Alexander , Cardiff Robert D.
Published: March 2023

PDF file - 2509K, Supplementary Figure 3. Heterologous differentiation in prostate.
Supplementary Figure 2 from Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-α Status
Authors: Harrison Hannah , Rogerson Lynsey , Gregson Hannah J. , Brennan Keith R. , Clarke Robert B. , Landberg Göran
Published: March 2023

PDF file - 8946K, Assessment of hypoxic culture and induction of HIF1α activated signalling
Supplementary Table 1 from ALX1 Induces Snail Expression to Promote Epithelial-to-Mesenchymal Transition and Invasion of Ovarian Cancer Cells
Authors: Yuan Hong , Kajiyama Hiroaki , Ito Satoko , Yoshikawa Nobuhisa , Hyodo Toshinori , Asano Eri , Hasegawa Hitoki , Maeda Masao , Shibata Kiyosumi , Hamaguchi Michinari , Kikkawa Fumitaka , Senga Takeshi
Published: March 2023

XLSX file - 131K, Details of patients' samples are described here
Supplementary Figures 1 - 4 from ALX1 Induces Snail Expression to Promote Epithelial-to-Mesenchymal Transition and Invasion of Ovarian Cancer Cells
Authors: Yuan Hong , Kajiyama Hiroaki , Ito Satoko , Yoshikawa Nobuhisa , Hyodo Toshinori , Asano Eri , Hasegawa Hitoki , Maeda Masao , Shibata Kiyosumi , Hamaguchi Michinari , Kikkawa Fumitaka , Senga Takeshi
Published: March 2023

PDF file - 161K, Cell lines subjected to in vitro invasion assay and soft agar colony formation assay (S1); SKOV3 cells that constitutively expressed GFP-ALX1 or siRNA-resistant GFP-ALX1 (ALX1-Res#2) was established by retrovirus infection (S2); SKOV3 cells were transfected with Ctrl or ALX1 siRNAs and cell growth was evaluated by MTT assay (S3); ALX1 induces EMT in NOS3 cells (S4)
Supplementary Table 2 from Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias
Authors: Rakowski Lesley A. , Garagiola Derek D. , Li Choi M. , Decker Margaret , Caruso Sarah , Jones Morgan , Kuick Rork , Cierpicki Tomasz , Maillard Ivan , Chiang Mark Y.
Published: March 2023

PDF file - 5445K, Table S2. Enrichment analysis of differentially regulated genes (fold change>1.3, p<0.01) after ZMIZ1 knockdown using C-MYC-related gene lists in the MSigDB Version 3.0 database.
Supplementary Figure S4 from scFv-Based “Grababody” as a General Strategy to Improve Recruitment of Immune Effector Cells to Antibody-Targeted Tumors
Authors: Cai Zheng , Fu Ting , Nagai Yasuhiro , Lam Lian , Yee Marla , Zhu Zhiqiang , Zhang Hongtao
Published: March 2023

Supplementary Figure S4 PDF file 583K, In vivo activity of h4D5 in the T6-17 model
Supplementary Table 1 from Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias
Authors: Rakowski Lesley A. , Garagiola Derek D. , Li Choi M. , Decker Margaret , Caruso Sarah , Jones Morgan , Kuick Rork , Cierpicki Tomasz , Maillard Ivan , Chiang Mark Y.
Published: March 2023

PDF file - 5445K, Table S1. Q-PCR primers used in this study.
Supplementary Methods from Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias
Authors: Rakowski Lesley A. , Garagiola Derek D. , Li Choi M. , Decker Margaret , Caruso Sarah , Jones Morgan , Kuick Rork , Cierpicki Tomasz , Maillard Ivan , Chiang Mark Y.
Published: March 2023

PDF file - 90K, Supplementary Methods. Viral constructs, viral production, transduction, bone marrow transplantation, flow cytometry, cell culture, Western blotting, immunoprecipitation, metabolic assays, xenotransplantation, dexamethasone treatment of T-ALL cell lines, GSI treatment of T-ALL cell lines, and supplementary references.
Supplementary Figure 9 from Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias
Authors: Rakowski Lesley A. , Garagiola Derek D. , Li Choi M. , Decker Margaret , Caruso Sarah , Jones Morgan , Kuick Rork , Cierpicki Tomasz , Maillard Ivan , Chiang Mark Y.
Published: March 2023

PDF file - 5445K, Figure S9. Enforced expression of C-MYC increased apoptosis.
Supplementary Figure S1 from scFv-Based “Grababody” as a General Strategy to Improve Recruitment of Immune Effector Cells to Antibody-Targeted Tumors
Authors: Cai Zheng , Fu Ting , Nagai Yasuhiro , Lam Lian , Yee Marla , Zhu Zhiqiang , Zhang Hongtao
Published: March 2023

Supplementary Figure S1 PDF file 1270K, Structural model of Fc�R - IgG Fc - domain B triple complex
Supplementary Figure 6 from Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias
Authors: Rakowski Lesley A. , Garagiola Derek D. , Li Choi M. , Decker Margaret , Caruso Sarah , Jones Morgan , Kuick Rork , Cierpicki Tomasz , Maillard Ivan , Chiang Mark Y.
Published: March 2023

PDF file - 5445K, Figure S6. ZMIZ1 does not regulate C-MYC post-transcriptionally or bind NOTCH1.
Supplementary Figure 8 from SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
Authors: Shin Dong Hoon , Choi Yong-Joon , Park Jong-Wan
Published: March 2023

PDF file 1293K, Localization of cytochrome c by immunofluorescence
Supplementary Figure 5 from Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias
Authors: Rakowski Lesley A. , Garagiola Derek D. , Li Choi M. , Decker Margaret , Caruso Sarah , Jones Morgan , Kuick Rork , Cierpicki Tomasz , Maillard Ivan , Chiang Mark Y.
Published: March 2023

PDF file - 5445K, Figure S5. The C-MYC pathway is downregulated after ZMIZ1 knockdown.
Supplementary Figure 7 from SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
Authors: Shin Dong Hoon , Choi Yong-Joon , Park Jong-Wan
Published: March 2023

PDF file 1207K, DNA fragmentation (TUNEL) and active caspase-9 expression
Supplementary Figure 4 from SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
Authors: Shin Dong Hoon , Choi Yong-Joon , Park Jong-Wan
Published: March 2023

PDF file 62K, Cell viability in H1299 and A549
Supplementary Figure 10 from Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias
Authors: Rakowski Lesley A. , Garagiola Derek D. , Li Choi M. , Decker Margaret , Caruso Sarah , Jones Morgan , Kuick Rork , Cierpicki Tomasz , Maillard Ivan , Chiang Mark Y.
Published: March 2023

PDF file - 5445K, Figure S10. ZMIZ1 inhibition sensitizes leukemic cells to NOTCH inhibitors.
Supplementary Figure 2 from SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
Authors: Shin Dong Hoon , Choi Yong-Joon , Park Jong-Wan
Published: March 2023

PDF file 63K, HIF-1α, HIF-2α, and SIRT1 levels
Supplementary Data from Fibroblast-Specific Protein 1/S100A4–Positive Cells Prevent Carcinoma through Collagen Production and Encapsulation of Carcinogens
Authors: Zhang Jinhua , Chen Lin , Liu Xiaoman , Kammertoens Thomas , Blankenstein Thomas , Qin Zhihai
Published: March 2023

Supplementary data PDF file 394K, Supplementary Figure 1/ Supplementary Figure 2. FSP1+ cells accumulate around the carcinogens DMBA and DEN. Supplementary Figure 3. Parts of FSP1+ fibroblasts express fibronectin, ER-TR 7 and laminin-1. Supplementary Figure 4. GCV administration at week 0 to 2 and week 8 to 10 does not influence tumor latency or tumor cell morphology. Supplementary Figure 5. FSP1+ cells in skin tissues after MCA injection highly expressed cyclin D1
Supplementary Methods, Figures 1 - 8 from Inhibition of Cholinergic Signaling Causes Apoptosis in Human Bronchioalveolar Carcinoma
Authors: Lau Jamie K. , Brown Kathleen C. , Thornhill Brent A. , Crabtree Clayton M. , Dom Aaron M. , Witte Theodore R. , Hardman W. Elaine , McNees Christopher A. , Stover Cody A. , Carpenter A. Betts , Luo Haitao , Chen Yi C. , Shiflett Brandon S. , Dasgupta Piyali
Published: March 2023

PDF file - 490K, Figure S1: Cell line authentication data Figure S2: Full screen western blots for ChAT, VAChT, AChE and CHT1 Figure S3: Immunohistochemistry of ChAT and VAChT in normal human lung tissues Figure S4: Nicotine-induced ACh production in human BAC requires nAChRs, VAChT, and CHT1 Figure S5: VAChT and ChAT are expressed on human BACs Figure S6: Transfection of VAChT siRNA and Sigma-R siRNA suppress the expression of these proteins in human BACs Figure S7: Effect of VAChT siRNA on the apoptotic activity of vesamicol in nicotine-treated BACs Figure S8: Overexpression of pcDNA3-HA-Akt-CA in A549 and H358 human BAC cells
Supplementary Figures 1 - 9 from Oncogenic Protein MTBP Interacts with MYC to Promote Tumorigenesis
Authors: Grieb Brian C. , Gramling Mark W. , Arrate Maria Pia , Chen Xi , Beauparlant Stephen L. , Haines Dale S. , Xiao Hua , Eischen Christine M.
Published: March 2023

PDF file - 687KB, Supplemental Figures S1-S9. S1 shows MTBP induces proliferation. S2 shows peptides in TIP48 and TIP49 identified by mass spectrometry. S3 shows Mtbp increases the pro-proliferative and transforming functions of Myc. S4 shows increased MTBP and MYC express correlates with poor colon and lung cancer survival. S5 shows the location of MTBP and MYC on 8q24. S6 shows Mtbp knockdown inhibits Myc-mediated transcription. S7 shows MTBP knockdown inhibits proliferation. S8 shows the C-terminus of Mtbp inhibits breast cancer cell expansion. S9 shows the working model of MTBP function.
Supplementary Table S1 from Chromothripsis and Focal Copy Number Alterations Determine Poor Outcome in Malignant Melanoma
Authors: Hirsch Daniela , Kemmerling Ralf , Davis Sean , Camps Jordi , Meltzer Paul S. , Ried Thomas , Gaiser Timo
Published: March 2023

Supplementary Table S1 PDF file 43K,Summary of aCGH gains and losses in the 18 MM samples
Supplementary Methods from Differential Contributions of STAT5A and STAT5B to Stress Protection and Tyrosine Kinase Inhibitor Resistance of Chronic Myeloid Leukemia Stem/Progenitor Cells
Authors: Casetti Luana , Martin-Lannerée Séverine , Najjar Imen , Plo Isabelle , Augé Sylvie , Roy Lydia , Chomel Jean-Claude , Lauret Evelyne , Turhan Ali G. , Dusanter-Fourt Isabelle
Published: March 2023

PDF file - 34K, Includes lentiviral constructs and transduction, immunoblots and antibodies, RNA extraction data, and supplementary references.
Supplementary Materials and Methods from Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling
Authors: Li Zhiping , Chen Ke , Jiao Xuanmao , Wang Chenguang , Willmarth Nicole E. , Casimiro Mathew C. , Li Weihua , Ju Xiaoming , Kim Sung Hoon , Lisanti Michael P. , Katzenellenbogen John A. , Pestell Richard G.
Published: March 2023

PDF file - 33KB
Supplementary Video 7 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: March 2023

MOV file - 8219K, This video shows the spatio-temporal evolution of vSkin that produced Figure 6b (minimally transformed melanocytes and highly senescent fibroblasts).
Supplementary Video 4 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: March 2023

MOV file - 6619K, This video shows the spatio-temporal evolution of vSkin that produced Figure 6A (normal melanocytes and mildly senescent fibroblasts).
Supplementary Figure Legend from Casein Kinase 1ϵ Promotes Cell Proliferation by Regulating mRNA Translation
Authors: Shin Sejeong , Wolgamott Laura , Roux Philippe P. , Yoon Sang-Oh
Published: March 2023

PDF file - 22K
Supplementary Figure 3 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Authors: Martini Miriam , Russo Mariangela , Lamba Simona , Vitiello Elisa , Crowley Emily Hannah , Sassi Francesco , Romanelli Davide , Frattini Milo , Marchetti Antonio , Bardelli Alberto
Published: March 2023

PDF file - 422K, A) Ctrl and MLK4 knock down (Sh1 and Sh2) Sw48 cells were stimulated with EGF (2nM-20 nM) at 37 {degree sign}C for 10 minutes. Cell lysates were subjected to western blotting with the indicated antibodies. B) Parental and MLK4 -/- HCT116 cells were stimulated with EGF (2nM-20 nM) at 37 {degree sign}C for 10 minutes. Cell lysates were subjected to western blotting with the indicated antibodies.
Supplementary Figure 4 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: March 2023

PDF file - 1504K,(A, B) The indicated amounts of PKH- and PKH+ cells from A549 cells were transplanted into 21-day old nude mice
Supplementary Figures 1 - 5 from Notch3 Pathway Alterations in Ovarian Cancer
Authors: Hu Wei , Liu Tao , Ivan Cristina , Sun Yunjie , Huang Jie , Mangala Lingegowda S. , Miyake Takahito , Dalton Heather J. , Pradeep Sunila , Rupaimoole Rajesh , Previs Rebecca A. , Han Hee Dong , Bottsford-Miller Justin , Zand Behrouz , Kang Yu , Pecot Chad V. , Nick Alpa M. , Wu Sherry Y. , Lee Ju-Seog , Sehgal Vasudha , Ram Prahlad , Liu Jinsong , Tucker Susan L. , Lopez-Berestein Gabriel , Baggerly Keith A. , Coleman Robert L. , Sood Anil K.
Published: March 2023

PDF file - 765K, Overall Survival (OS) Analysis in Patients With High-Grade Serous Ovarian Cancer HGS-OvCa (S1); In Vitro Functional Studies of Notch3 siRNA or GSI and combined with Paclitaxel in OvCa Cells (S2); qRT-PCR Analysis of Expression of Gamma-Secretase Complex in Ovarian Cancer Cells (S3); In vitro effects of blocking endocytosis on Jagged-1/Notch3 pathway in cancer cells (S4); In vivo study of Notch3 siRNA in orthotopic mouse models of ovarian cancer (S5).
Supplementary Table 8 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: March 2023

XLSX file - 39K, Results of upstream activator and regulator IPA analysis based on the gene list in Supplementary Table 5.
Supplementary Table 6 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: March 2023

XLSX file - 14K, Set of most significantly enriched biological functions as deterermined by IPA analysis based on the gene list in Supplementary Table 5.
Supplementary Figures 1-6 from CD40-Mediated Activation of Chronic Lymphocytic Leukemia Cells Promotes Their CD44-Dependent Adhesion to Hyaluronan and Restricts CCL21-Induced Motility
Authors: Girbl Tamara , Hinterseer Elisabeth , Grössinger Eva Melanie , Asslaber Daniela , Oberascher Karin , Weiss Lukas , Hauser-Kronberger Cornelia , Neureiter Daniel , Kerschbaum Hubert , Naor David , Alon Ronen , Greil Richard , Hartmann Tanja Nicole
Published: March 2023

PDF file - 245K, Supplementary Figure S1: Activated, autologous T cells induce CLL cell proliferation. Supplementary Figure S2: CD40L activated CLL cells fully retain their chemotactic response towards CCL21. Supplementary Figure S3: PMA/ionomycin and IgM cross-linking induces FL-HA binding. Supplementary Figure S4: CD44 surface expression on CLL patients does not differ between clinical risk groups. Supplementary Figure S5: The CLL cell subpopulation remaining CD44v6 negative after CD40L-activation displays low activation levels. Supplementary Figure S6: The mAbs used for immunoblotting specifically recognize panCD44 and CD44v6
Supplementary Table 2 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: March 2023

XLSX file - 28K, RNA-QC, sequencing, and clinical metadata on the 106 samples sequenced in this study.
Supplementary Figure Legend from Polo-like Kinase 1: A Potential Therapeutic Option in Combination with Conventional Chemotherapy for the Management of Patients with Triple-Negative Breast Cancer
Authors: Maire Virginie , Némati Fariba , Richardson Marion , Vincent-Salomon Anne , Tesson Bruno , Rigaill Guillem , Gravier Eléonore , Marty-Prouvost Bérengère , De Koning Leanne , Lang Guillaume , Gentien David , Dumont Aurélie , Barillot Emmanuel , Marangoni Elisabetta , Decaudin Didier , Roman-Roman Sergio , Pierré Alain , Cruzalegui Francisco , Depil Stéphane , Tucker Gordon C. , Dubois Thierry
Published: March 2023

PDF file - 66K