bluuebunny/crossref_metadata_2025 huggingface dataset:
RAISON ET IMAGINATION CHEZ GASTON BACHELARD
Authors: Ferreira Gomes Ana Laudelina
Published: December 2024

Il s’agit de la construction d’une problématique sur la relation entre le réel et le rationnel, l’expérience et la raison, autant dans l’épistémologie que dans la poétique bachelardienne. Dans le premier cas, l’immédiat doit céder de l’espace au construit, dans le second, à travers la notion de rythme, l’homme est intégré à la nature et non déduite à celle-ci. Ainsi, dans la poétique bachelardienne, l’image correspondrait à un rythme, crée une image poétique qui, en termes temporels, comme dit J.J. Wunenburger, produit, en même temps, permanence et différence, continuité et discontinuité. En prenant en compte cettenotion de rythme, nous pouvons penser que, pour Bachelard, autant la science -comme phénoménotechnique-, que la poésie -comme métaphysique instantanée- sont sous les signes de la répétition et de la nouveauté. Dans la science, par la voie du rationalisme appliqué, où, selon Bachelard, rationalisme et empirisme se dialectisent. Dans la poésie, cette association répétition-nouveauté arrive par deux voies, celle de l’imagination des matières élémentaires et celle de la phénoménologie de l’imagination. Ainsi, nous pouvons penser que, tandis que dans l’épistémologie bachelardienne, répétition-nouveauté (rythme)en science est engendrée par la raison -dans sa fonction d’agressivité et de turbulence sur la connaissance déjà accumulée et sur l’inconnu- ; dans la poétique bachelardienne, elle est produite par l’imagination, comprise comme faculté de déformation du réel, ou, comme le veut Wunenburger, comme inversion du réel.
DIVISÃO SEXUAL DO TRABALHO E SEGREGAÇÃO OCUPACIONAL
Authors: Monteiro Costa Ana , Bezerra Ribeiro Marcela , Gatto Maria Fernanda
Published: December 2024

O objetivo deste estudo consiste na realização de uma sucinta análise da divisão sexual do trabalho, motivada pela observação empírica de que existe uma grande disparidade entre os sexos no mercado de trabalho, tanto no quesito de alocação de funções quanto na valorização do serviço de cada um. Utilizando-se da revisão de literatura sobre o tema, reforçada pela análise descritiva de dados comparativos, foi possível concluir que o mercado de trabalho brasileiro está sujeito à segregação ocupacional por gênero, sendo permeado por discriminação e por desvalorização do trabalho feminino, alocando, em grande escala, as mulheres em ocupações precárias.
ENTREVISTA A MARCIA DOS SANTOS MACEDO
Authors: Freire Barbosa Anna Christina , De Sousa Heloisa
Published: December 2024

A entrevista realizada em novembro/2021 com a Profa. Dra. Márcia dos Santos Macedo seguiu perguntas sobre Gênero e Sexualidade, de modo a buscar registrar sua ampla experiência nessa temática, o que fica claramente evidenciado em sua introdução, em que ela faz um retrospecto de sua experiência profissional na UFBA. No decorrer da entrevista – que foi gravada e depois transcrita –, muitas vezes, Márcia já adaptava a nossa questão ao que ela pretendia responder, ou seja, interligando a sua experiência profissional nesse campo. Suas respostas estão relacionadas às questões que nós da Cronos a ela formulamos, e respondidas com base na experiência coletiva da UFBA.
ALLURING, MELANCHOLY AND BEAUTIFUL
Authors: Oliveira Junior Ribamar José de , Jaramillo Gil Huber David
Published: December 2024

This study examines queer sensibilities as they emerge in the photographic oeuvres of Severo Sarduy (Cuba, 1937-1993), Pedro Lemebel (Chile, 1952-2015), Alair Gomes (Brazil, 1921-1991) and Hudinilson Junior (Brazil, 1957-2013). In doing so, we consider in the images what can be seen as queer baroque. Within beauty, mystery and seduction, we find queer affect that revisits not only the baroque, but the neo-baroque in its aesthetic dimension. What the photographs transmit are performative overflows that emulate in the bodies ways of refusing social conventions. When working with sensitivity, we touch the images through affective interaction, and we realize how the body can be read by desire.
RESENHA DE LIVRO DE RACHEL HOLMES
Authors: Freitag-Rouanet Barbara
Published: December 2024

Resenha
LÚCIA MIGUEL PEREIRA
Authors: A. Ribeiro Lopes de Almeida Edwirgens
Published: December 2024

Lúcia Miguel Pereira é uma escritora conhecida por sua atuação no mundo das letras. Porém, o reconhecimento se deu por seu trabalho como crítica literária nas primeiras décadas do século XX, sendo que, além de crítica, ela possui um acervo significativo de quatro romances e quatro contos infantis, bem como alguns textos biográficos. O pensamento exposto nos primeiros trabalhos evidencia uma visão conservadora, espiritualista, a partir da qual é possível perceber ideias que caminham em uma direção de extrema-direita, atuante nos anos 1930. Assim, ainda que seja frequente o questionamento sobre o lugar social da mulher naquele contexto, em sua prosa de ficção, notamos certa contradição ao colocar em discussão o movimento feminista, incipiente naqueles tempos.
APRESENTAÇÃO DE CAPA
Authors: De Souza Almeida Geovane
Published: December 2024

Apresentação de capa
FORMAS DE APARICIÓN DE FEMINIDADES TRANS* EN DOS ARCHIVOS DEL ESTADO NACIONAL ARGENTINO
Authors: De Santo Mag
Published: December 2024

Con el presente trabajo me propongo esbozar una caracterización de las formas de representación impuestas por el Estado Nacional, en tanto Estado Moderno Colonial, con el propósito de dar cuenta de algunos elementos de la matriz de inteligibilidad que se mantiene desde finales del siglo XIX hasta finales del siglo XX para personas trans*. De este modo, me he interesado en generar un incipiente aporte a las narrativas de los Organismos de Derechos Humanos, así como a las teorías que asumen la interdependencia constitutiva y productiva de las estructuras opresivas patriarcales-capitalistas y raciales. Los materiales a los que le realizo las preguntas de investigación son principalmente dos acervos documentales atesorados por las estructuras de poder jurídico-médica- administrativas cuya impronta ofrece algunas delimitaciones metodológicas. Desde este punto de partida, pongo el foco en la emergencia y aparición de feminidades trans* en dos archivos en particular: la revista Archivos de psiquiatría y criminología aplicada a las ciencias afines. Medicina legal-sociología-derecho-psicología-pedagogía (1902-1913) y el Archivo de la Dirección de Inteligencia de la Policía de la Provincia de Buenos Aires (DIPBA), que estuvo activa entre 1956 y 1998. Destaco la aparición de “invertidos sexuales” en el primero y el caso de Mariela Muñoz en el segundo, trazando continuidades y discontinuidades en el modo de aparecer, especialmente poniendo atención en las omisiones y tergiversaciones nominales y territoriales de la emergencia de tales sujetos.
Potencial uso del orujo de oliva en la producción de pavimento tipo parquet
Authors: Nazer Amin , Sepúlveda Bernardo , Pavez Osvaldo , Aguilar Luciano
Published: December 2024

La investigación sobre los nuevos usos para los subproductos del olivar, en especial el orujo generado durante la producción de aceite, es crucial tanto para la economía como para el medio ambiente de las comunidades donde se cultiva este árbol. En Chile, la producción de aceite de oliva genera orujo, considerado un desecho. En este estudio, se propone reutilizar el orujo para fabricar un pavimento de interiores tipo parquet. Se moldeó una mezcla de orujo en palmetas de 25 x 10 x 2 cm, observando un secado rápido.Antes de su endurecimiento en un ambiente controlado de laboratorio, se caracterizaron las palmetas obteniendo una densidad de 0.842 g/cm3, y contracción del 8.4% ±0.5%. El prototipo pudo ser clavado, pero se descascaró como los aglomerados comerciales; además mostró buena firmeza, pero poca resistencia al taladrado y atornillado. El material puede ser aserrado, resistiendo adecuadamente a la sierra y soporta más de 150 kg de peso, mostrando una buena resistencia estructural. Las palmetas de orujo presentaron una dureza adecuada, manteniendo sus propiedades de clavado y atornillado. Este prototipo de parquet podría seruna alternativa valiosa para valorizar el potencial uso del orujo, contribuyendo a la economía circular de la región y de las zonas olivareras.
Xuebijing Exerts Protective Effects on Myocardial Cells by Upregulating TRIM16 and Inhibiting Oxidative Stress and Apoptosis
Authors: Meng Xiaoyan , Yan Xinming , Xue Peng , Xi Zhaoqing
Published: December 2024

Objective:

This study utilized transcriptomic sequencing combined with cellular and
animal models to explore the potential mechanisms of Xuebijing in treating sepsis-induced myocardial
dysfunction, also known as sepsis-induced myocardial injury.

Methods:

We investigated potential targets and regulatory mechanisms of XBJ injection using
network pharmacology and RNA sequencing. The effects of XBJ on oxidative stress and apoptosis
levels in human cardiac myocytes (AC16) and C57BL/6 mice exposed to lipopolysaccharide
(LPS) were evaluated by Enzyme-Linked Immunosorbent Assay (ELISA), fluorescent probe,
Fluorescent Quantitative Polymerase Chain Reaction (qPCR), Western Blot, Transmission Electron
Microscopy, oxidative stress-related indicators detection kit, flow cytometry, and Immunohistochemistry
(IHC).

Results:

First, it was verified that XBJ can reduce the deformation of AC16 cardiomyocytes induced
by LPS and the production and secretion of ROS (P <0.01). The transcriptome sequencing
results showed that the TRIM16 gene was significantly increased after XBJ treatment, and the
data of KEGG and GO analyses demonstrated that XBJ could inhibit the pathway expression
of oxidative stress damage in AC16 cells, and PCR verified that XBJ could indeed increase
the expression level of TRIM16 gene in AC16 cells (P <0.01). Basic animal and cell experiments
showed that LPS could inhibit the expression of TRIM16 and NRF2 in cardiomyocytes
(P <0.05) and promote the expression of Keap1 (P <0.01), while XBJ could significantly upregulate
the expression levels of TRIM16 and NRF2 (P <0.01) and inhibit the expression of
Keap1 (P <0.01), thereby affecting the expression levels of downstream proinflammatory cytokines
and alleviating LPS-induced oxidative stress damage. In addition, XBJ also inhibited the
expression of the pro-apoptotic proteins Bax and c-caspase3 (P <0.01), promoted the expression
of the anti-apoptotic protein Bcl2 (P <0.01), and reduced LPS-induced apoptosis by upregulating
TRIM16.

Conclusion:

Our comprehensive data demonstrated that TRIM16 is a key gene in the therapeutic
action of Xuebijing in sepsis-induced myocardial dysfunction, protecting myocardial cells from
injury through antioxidative stress and anti-apoptotic mechanisms.
Autism Spectrum Disorder: Clinical and Genetic Aspects
Authors: Shukla Shalu
Published: December 2024

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by
challenges in social communication and the presence of repetitive behaviors and restricted interests.
It is acknowledged as a complex, multifactorial disorder influenced by both genetic and nongenetic
factors. Recent advancements in neuroimaging studies have provided valuable insights into
the observable changes in the brains of individuals with ASD. It is estimated that worldwide,
about 1 in 100 children has autism. This estimate represents an average figure and reported prevalence
varies substantially across studies. This review aims to explore factors influencing prevalence
rates, highlighting the significant roles played by both genetic and environmental factors in
the development of ASD. Furthermore, a recent study delved into the cellular structure, size, and
shape of the brains of ASD individuals, revealing notable differences across various brain regions.
The disparities were particularly pronounced in certain areas. While educational and behavioral
treatments have traditionally been primary in managing ASD, there is growing recognition of the
potential benefits of pharmacological and interventional approaches. This review strives to elucidate
the diverse pathophysiological mechanisms contributing to the onset of Autism, as well as to
provide insights into therapeutic interventions for the condition, emphasizing a multifaceted approach
to treatment.
Pharmacological Activities of Warm Alkaline Hydrogen Peroxide Solution and Therapeutic Potential in Medicine: Physical-Chemical Reprofiling as a Promising Lead for Drug Discovery
Authors: Urakova Natalya , Urakov Aleksandr , Shabanov Petr
Published: December 2024

The traditional use of antiseptics, chemotherapeutic, expectorant, mucolytic drugs, and oxygen gas by artificial ventilation does not effectively eliminate hypoxemia in sputum, mucus, pus, and blood asphyxia in COVID-19. The emergency conversion of sputum, mucus, pus, and blood into oxygenated foam inside the airways utilizing the enzyme catalase and warm alkaline hydrogen solutions (WAHPSs) is proposed as a promising area for new therapeutic development.. The possibility of physical-chemical repurposing of hydrogen peroxide from an antiseptic in pyolytics, mucolytics, hemolytics, and oxygen-producing antihypoxants by con-verting a cold, acidic non-carbonated drug into an oxygen-saturated WAHPS and its intrap-ulmonary injection is pointed out as a way to solve this problem. The possibility of medically enriching blood oxygen in hypoxemia by catalase cleavage of hydrogen peroxide when WAHPSs are administered orally as energy drinks or directly into the blood as injections is pointed out. The fact is that virtually all human tissues are rich in catalase, which immediately breaks down hydrogen peroxide into water and oxygen gas. Inhalation and/or intrapulmonary injections of WAHPSs have been shown to provide intra-airway interaction with catalase in sputum, mucus, pus and/or blood and releases oxygen gas, which foams the biological masses, is absorbed into the blood and eliminates hypoxemia. Thus, the physical-chemical repurposing of known drugs can be considered a promising direction for the discovery of new drugs.
Value of the data:
1) Why are these data useful?
These studies indicate that the enzyme catalase, which is present in many tissues of animals and humans in both normal and disease, can be employed to enrich the tissues with oxygen and eradicate hypoxia when hydrogen peroxide solution is injected into them..
2) Who can benefit from these data?
Mountaineers, divers, submarine sailors, miners, astronauts, traumatologists, resuscitators, car-diologists, transplantologists, pulmonologists, obstetricians and gynecologists, emergency phy-sicians, EMERCOM personnel, and medical workers, providing emergency medical care in cases of smoke in rooms, lack of oxygen in the inhaled air, drowning, bronchial asthma attack, acute respiratory distress syndrome, and asphyxia can use the data presented in this article.
3) How can these data be used/reused for further insights or development of experi-ments?
These data can be used to develop new antihypoxants, to improve methods of increasing the organism's endurance to hypoxia, methods of organ and tissue preservation, methods of ische-mia treatment, methods of emergency medical care in urgent conditions, methods of ARDS treatment and standards of medical care.
FDA Novel Approvals of Pharmaceuticals, 2013-2022: An Observational Study
Authors: Misra Saurav , Shukla Ajay Kumar
Published: December 2024

Background:

Novel drugs often mean new patient treatment options and advances in health care for humanity. This study, which delves into the trends of drug approvals by the FDA in the last decade, from CY 2013 to 2022, is of significant importance to the medical community and policymakers in the pharmaceutical industry.

Methods:

US-FDA's free, open-source, online database for novel drug approvals from 2013 to 2022 was used. FDA novel drug approvals were analysed from calendar year (CY) 2013 to 2022 based on their numbers and impact, innovation, access, and predictability.

Results:

The total number of drugs approved from CY 2013 to 2022 was 428 (average of 43 novel drugs/ year). 40% were first-in-class drugs. Access to novel drug approvals: 87% were first-cycle approvals, and 72% were approved in the US before other countries. Drug approv-al statistics: 26% priority reviews, 12% breakthrough approval, 16% fast track approval and 12% expedited approval among novel drug approvals. Predictability of novel drug approvals: 98% of approvals can meet PDUFA goal dates for application review. The most common drug class was anticancer drug (26%), and the most common administration route was oral (86%). One hundred two drugs have been approved with black box warnings, and 25 FDCs (Fixed dose combinations) were approved from 2013 to 2022.

Conclusions:

The novel drug approvals during CY 2013-2022 were of high quality, as evi-denced by their high impact, good access, and high predictability. Our study provides a com-prehensive insight into FDA-approved drugs, offering valuable information to the medical community and policymakers in the pharmaceutical industry.
Klimaat, biodiversiteit en de christelijke traditie
Authors: Boersema J.J.
Published: December 2024

In this article, I will show how the two major environmental issues of our time, man-made climate change and biodiversity decline, are connected to Christian thought about creation and history. Views on the character of time and related notions of progress and growth are relevant to the first issue; views on changes in creation as a result of the fall to the second. Finally, I will argue that the pursuit of sustainability requires a supporting narrative. Christianity, despite its fraught past, has important ingredients for such a narrative.
Analysis of entrepreneurial readiness of family welfare education study program students concentrating in culinary arts
Authors: Hamid Yuli Heirina , Fadhilah Fadhilah , Suhairi Laili , Gagarin Yuri , Abdullah Abdullah
Published: December 2024

Research on student readiness for entrepreneurship is very important to understand how to enter the business world better. This study aims to describe the entrepreneurial readiness of students of the Family Welfare Education Study Program specializing in Culinary Arts at Syiah Kuala University. This type of research is descriptive quantitative. The study population was 150, with a sample of 100 students. The sampling technique used is proportional random sampling. Data collection was done using a questionnaire that was tested for validity and reliability. Data were analyzed through descriptive analysis using the assessment categorization method based on the average score and percentage assessment. The results concluded that the entrepreneurial readiness of students is in the moderate category. This study shows that the personality, motivation, skills, and knowledge of students are not sufficient to foster entrepreneurial readiness, especially in the Family Welfare Education Study Program specialization in Culinary Arts, Syiah Kuala University. This research will make a new contribution to the academic literature related to student entrepreneurial readiness, especially in the context of the Family Welfare Education Study Program with a concentration in Catering, by enriching our understanding of the factors that influence student readiness to run a business in the culinary field.
Integration of Malay-Indonesian anatomical proportions in vocational education curriculum for technical illustration and engineering design
Authors: Maskat Suryadi , Masunah Juju , Soeteja Zakarias Sukarya , Nguyen Kieu-Trang
Published: December 2024

This study aims to identify the anatomical body proportions of Malay-Indonesian males as an essential reference in vocational education, particularly for developing curricula in technical drawing and engineering illustration. Using a content analysis method, the study sample consists of 1,000 Malay men from various provinces in Indonesia. Data were collected through photographic documents and analyzed based on age, gender, and ethnicity. The ratio of body to head size was measured to identify relevant characteristics of body proportions. The results show that Malay male body proportions are shorter compared to Europeans; while the European body proportion is eight times the head size, the Malay proportion is seven times the head size. These findings have important implications for vocational education in designing curricula and instructional materials that are more accurate and relevant to local anthropometric characteristics. Understanding these body proportions enables vocational institutions to develop more effective programs in technical drawing and design education that are contextually appropriate. This research contributes to improving the quality of vocational education by providing empirical data as a reference for more culturally relevant and contextually appropriate drawing techniques and training.
Influence of ethical management on politics in performance appraisal: Development and validation of a causal model
Authors:   School of Business Management, College of Business, University Utara Malaysia, Sintok, Malaysia, Daud Zulkiflee , Elsaman Hosam ,   School of Business Management, College of Business, University Utara Malaysia, Sintok, Malaysia, Ahmad Rusli ,   Faculty of Business, University of Sohar, Sohar, Oman, Mutazam Mazli ,   School of Business Management, College of Business, University Utara Malaysia, Sintok, Malaysia, Sallehuddin Rashdan ,   School of Business Management, College of Business, University Utara Malaysia, Sintok, Malaysia, Haron Nasiruddin ,   School of Business Management, College of Business, University Utara Malaysia, Sintok, Malaysia, ZainolAbidin Abidzar ,   School of Business Management, College of Business, University Utara Malaysia, Sintok, Malaysia
Published: December 2024

This study examines the impact of the ethical Management concept on perceptions of organizational politics in performance appraisal within the context of Malaysia's rapidly growing economy and its demand for effective human resource policies in the financial sector. Addressing the risks of workplace politics that can lead to performance errors and reputational harm, the research employed a quantitative approach, utilizing a questionnaire distributed to 274 officers and clerical staff selected through proportionate stratified random sampling in a Malaysian government financial institution in Kuala Lumpur. Exploratory factor analysis and data validation identified three dimensions of organizational politics in performance appraisal and six dimensions of the Ethical Management concept: work commitment, social obligation, justice, job satisfaction, creative work, and productivity. The findings revealed that work commitment, justice, job satisfaction, and creative work were significantly influenced by the perception of benefits, emphasizing their role in improving organizational outcomes. This study contributes to the development of a model linking the Ethical Management concept to organizational politics, offering insights for enhancing organizational performance through improved management practices.
Preporuke za dijagnozu i liječenje ronilačkih bolesti
Authors: Cvitanović Dijana , Jovović Pavle , Brdar Ivan , Majhen Ujević Radmila , Bošan– Kilibarda Ingrid , Olujić Vida , Milas Helena , Ferri Certić Ivana
Published: December 2024

Tijekom ronilačkih aktivnosti mogu se javiti specifične bolesti ili ozljede koje su vezane za ronjenje. U ronilačke bolesti/ozljede ubrajaju se dekompresijska bolest, barotraume, dušikova narkoza i toksično djelovanje plinova pod povišenim tlakom. Dekompresijska bolest i barotraume nastaju uslijed promjena tlaka okoline (ambijentalni tlak) te se još nazivaju i disbaričke bolesti ili ozljede. Dekompresijska bolest može se prezentirati različitim kliničkim stanjima, a u pravilu 98 % slučajeva razvija se unutar prvih 24 sata nakon završetka ronjenja. Simptomi bolesti su raznoliki te ako postoje sumnje ili dvojbe u dijagnozi i/ili liječenju unesrećenog ronioca, važno je pozvati pripravnog liječnika u odgovarajućem rekompresijskom središtu. Specifične ronilačke bolesti zahtijevaju rano prepoznavanje te pravodobno i odgovarajuće zbrinjavanje neposredno nakon same ronilačke nesreće. Liječenje ronilačkih bolesti/ozljeda započinje primarnim zbrinjavanjem unesrećenog koje se obavlja u okviru djelovanja hitne medicinske službe, a koje uz uobičajene mjere akutnog zbrinjavanja i liječenja mora obuhvatiti i kontinuiranu primjenu 100-postotnog kisika i nadoknadu tekućine. Važno je rano postavljanje ispravne indikacije liječenja u barokomori te organizacija ovog liječenja u odgovarajućoj zdravstvenoj ustanovi. Prilikom prijevoza ronioca do barokomore preporuka je održavanje nadmorske visine koja nije viša od 150 metara u odnosu na nadmorsku visinu mjesta preuzimanja. Konačno liječenje provodi se postupcima rekompresijskog liječenja. Ove preporuke predstavljaju trenutno stanje znanja i preporuke su o dijagnozi i liječenju žrtava ronilačkih nesreća.
Preporuke za liječenje sepse i septičkog šoka u hitnoj medicinskoj službi
Authors: Srzić Ivana , Nesek Adam Višnja , Peršec Jasminka , Jurić Ivan , Tunjić Pejak Darinka , Bujas Padovan Ozana , Crnčević Tomislav , Leš Mihaela , Matolić Martina
Published: December 2024

Sepsa je jedan od vodećih uzroka morbiditeta i mortaliteta u svijetu. Učestalost sepse i septičkog šoka u kontinuiranom je porastu još od konsenzus-definicije iz 1991. god. Danas se smatra desetim najčešćim uzrokom smrti u općoj populaciji. Teško je utvrditi sveukupni teret sepse, procjena je da je 2017. god. u svijetu bilo 48,9 milijuna slučajeva i 11 milijuna smrtnih slučajeva povezanih sa sepsom, što je gotovo 20 % svih globalnih smrtnih slučajeva. Kod septičkog šoka kao podskupine sepse bolnička smrtnost je gotovo 60 %. Ovi podatci naveli su Svjetsku zdravstvenu organizaciju (SZO) da proglasi sepsu globalnim zdravstvenim prioritetom. Budući da je hitna medicinska služba primarno mjesto gdje se najčešće uspostavlja prvi kontakt sa septičnim bolesnikom, liječnici hitne medicine imaju značajnu ulogu u ranoj fazi liječenja navedenih bolesnika. Cilj je ovih kliničkih preporuka prikazati postupnik ranog prepoznavanja, dijagnostiku i liječenja sepse i septičkog šoka u hitnoj medicinskoj službi.
Važnost recenzijskog postupka u časopisima nižeg čimbenika odjeka
Authors: Batičić Lara
Published: December 2024

Recenzijski postupak nije samo administrativni korak u publikaciji znanstvenih i stručnih radova, već predstavlja temelj kvalitete i dugoročne održivosti znanstvene zajednice. Unatoč manjoj vidljivosti časopisa nižeg čimbenika odjeka na globalnoj razini, recenzijski postupak osigurava očuvanje visokih znanstvenih standarda te temeljitu provjeru ispravnosti i relevantnosti rukopisa. Recenzijski postupak ključan je u održavanju integriteta znanstvene komunikacije, posebno u časopisima koji se bore za prepoznatljivost u širem znanstvenom prostoru. Osim poboljšanja kvalitete istraživačkih radova, recenzijski postupak igra i ključnu ulogu u održavanju etičkih standarda unutar znanstvene zajednice. Časopisi s nižim čimbenikom odjeka često objavljuju radove koji se bave specifičnim temama ili regionalnim pitanjima koja su zanemarena u većim međunarodnim časopisima. U kontekstu hrvatskog jezika i lokalnog istraživačkog okruženja, ovaj proces omogućuje ne samo održavanje visoke razine znanstvene produkcije već i jačanje zajedništva među istraživačima, čime se pridonosi razvoju cijele znanstvene zajednice u Hrvatskoj. U maloj hrvatskoj znanstvenoj zajednici, gdje je broj istraživača i institucija često ograničen, kvalitetna recenzija može značajno utjecati na razvoj znanstvene komunikacije i reputaciju domaćih časopisa.
Technology Adoption Paradigm in Older Adults: A Systematic Qualitative Grounded Theory Review (Preprint)
Authors: Gandomkar Fatemeh , Pirzadeh Nasim , Bahadori Farzaneh , Zandieh Zhale , Abolfathi Momtaz Yadollah , Mohammadi shahboulaghi Farahnaz
Published: December 2024

BACKGROUND

With the widespread use of technology in everyday life, older adults' acceptance of technology has become critical to their ability to operate in today's society.

OBJECTIVE

This review study aimed to provide a deep understanding of technology adoption among older adults and identify the technology adoption paradigm in this population.

METHODS

This research used electronic databases such as PubMed, Web of Science, Scopus, and Google Scholar.

RESULTS

This study presents comprehensive information on the factors influencing technology acceptance, which can help improve the adoption process for older adults. Identifying barriers and effective facilitators can lead to enhanced cooperation among technology designers and providers, ultimately increasing technology adoption rates. Additionally, understanding the potential consequences of technology adoption can influence policymakers to implement supportive measures and policies.

CONCLUSIONS

By identifying the effective factors in technology adoption, the rate of technology adoption among older adults can be predicted to increase in the coming years.
AI Chatbots for Psychological Health for Health Professionals: A Scoping Review (Preprint)
Authors: Han Jin-Hui , Baek Gumhee , Cha Chiyoung
Published: December 2024

BACKGROUND

Health professionals face significant psychological burdens including burnout, anxiety, and depression, which can negatively impact their well-being and patient care. Traditional psychological health interventions often encounter limitations such as a lack of accessibility and privacy. Artificial intelligence (AI) chatbots are emerging as promising solutions to these challenges by providing accessible and immediate support. Therefore, it is necessary to systematically evaluate the characteristics and effectiveness of AI chatbots designed specifically for health professionals.

OBJECTIVE

This scoping review aims to evaluate the existing literature on the use of AI chatbots for psychological health support among health professionals.

METHODS

Following Arksey and O’Malley’s framework, a comprehensive literature search was conducted across eight databases, covering articles published from 2018 to 2024, including backward and forward citation tracking and manual searching from the included articles. Articles were screened for relevance based on inclusion and exclusion criteria, among 2,465 articles retrieved, 10 met the criteria for review.

RESULTS

Among the 10 articles, three employed a development study design. Six chatbots were delivered via mobile platforms, and four via web-based platforms, all enabling one-on-one interactions. Natural language processing (NLP) algorithms were commonly used and cognitive behavioral therapy (CBT) techniques were applied to psychological health in four articles. Usability was evaluated in six articles, with generally high satisfaction rates; however, dropout rates remained high, particularly in emotionally intense situations. Improvements in anxiety, depression, and burnout were observed in four studies, although one reported an increase in depressive symptoms.

CONCLUSIONS

AI chatbots show promise as tools to support the psychological health of health professionals by offering personalized and accessible interventions. Nonetheless, further research is required to establish standardized protocols and validate the long-term effectiveness of these interventions. Future studies should focus on refining chatbot designs and assessing their impact on diverse health professionals.
Performance Improvement of the Natural Language Processing Tool to Extract Patient Narratives Related to Medical States From Japanese Pharmaceutical Care Records: Effects of an Increase in the Amount of Training Data (Preprint)
Authors: Ohno Yukiko , Aomori Tohru , Nishiyama Tomohiro , Kato Riri , Fujiki Reina , Ishikawa Haruki , Kiyomiya Keisuke , Isawa Minae , Mochizuki Mayumi , Aramaki Eiji , Ohtani Hisakazu
Published: December 2024

BACKGROUND

To improve pharmacotherapy, patients’ oral expressions serve as valuable sources of clinical information. Natural language processing (NLP) is a useful approach for analyzing unstructured text data, such as patient narratives. However, few studies have focused on using NLP for narratives in the Japanese language.

OBJECTIVE

To develop a high-performance NLP system for extracting clinical information from patient narratives, we examined the performance progression as the amount of training data was gradually increased.

METHODS

Subjective texts from the pharmaceutical care records of Keio University Hospital from April 1, 2018 to March 31, 2019, comprising 12,004 records from 6,559 cases, were used. After preprocessing, we annotated diseases and symptoms within the texts. We then trained and evaluated deep learning models—bidirectional encoder representations from transformers combined with a conditional random field (BERT-CRF)—by 10-fold cross-validation. The annotated data were divided into 10 subsets, and the amount of training data was progressively increased over 10 steps. We also analyzed the causes of errors. Finally, we applied the developed system to the analysis of case report texts to evaluate its usability for texts from other sources.

RESULTS

The F1-score of the system improved from 0.67 to 0.82 as the amount of training data increased from 1,200 to 12,004 records. The F1-score reached 0.78 with 3,600 records and largely saturated thereafter. As performance improved, errors from incorrect extractions decreased significantly, increasing precision. For case reports, the F1-score also increased from 0.34 to 0.41 as the training dataset expanded from 1,200 to 12,004 records. Performance was lower for extracting symptoms from case report texts compared with pharmaceutical care records, suggesting that this system is more specialized for analyzing subjective data from pharmaceutical care records.

CONCLUSIONS

We successfully developed a high-performance system specialized in analyzing subjective data from pharmaceutical care records by training a large dataset, with near-complete saturation of system performance with about 3,600 training records. This system will be useful for monitoring symptoms, offering benefits for both clinical practice and research.
Engineering Resilient Community Pharmacies: A Protocol for Exploring an Integrative Approach to Medication Safety (Preprint)
Authors: Chui Michelle A , Berbakov Maria E , Gilson Aaron M , Stone Jamie A , Lehnbom Elin C , Hoffins Emily L , Moore Katherine G , Ford II James H
Published: December 2024

BACKGROUND

The increase of people with complex chronic health conditions is stressing the U.S. healthcare delivery system. Community pharmacies play a role in ensuring patients’ safe medication use for chronic care management, but their efforts are undermined by volatile work demands and other system barriers.

OBJECTIVE

This study seeks to conceptualize, design, implement, and test a MedSafeMapTM for the community pharmacy setting to enhance pharmacists’ and technicians’ abilities to either avoid, or to quickly identify and recover from, medication errors before patient safety is endangered.

METHODS

Aim 1: Four rounds of observations within the six pharmacy sites will be conducted to parse out areas MedSafeMap could address. Two rounds of interviews with a different one pharmacist and technician from each of the sites will be used to expand upon areas of interest identified during the observations. Aim 2: Focus groups with pharmacists and technicians will aid in the design of MedSafeMap components. Simulation-based research will be utilized to test MedSafeMap components with standardized patients in complex care managament scenarios. Aim 3: MedSafeMap will be implemented into pharmacies. Observations using WOMBAT for time and motion study will aid in understanding how MedSafeMap impacts pharmacy staff workflow.

RESULTS

As of November 15th, 2024, all six pharmacy sites have been recruited and three of four rounds of observations have been completed. Interviews have been conducted with 12 pharmacists and 11 technicians from the study sites. Preparations for Aim 2 are in the works as Aim 1 analysis continues.

CONCLUSIONS

The MedSafeMap is an innovative approach that will be used by pharmacists and pharmacy technicians to better navigate the complex tasks in the pharmacy, and to facilitate communication with both patients and clinicians, while safely providing medications to complex patients with chronic health conditions.
The influence of information platform based personalized self-management prescription on type 2 diabetes in China: A real-world cohort study (Preprint)
Authors: Amuti Reziwanguli , Amuti Reziwanguli , Kadier Areziguli , Jiang Mengting , Maihemuti Abudureheman
Published: December 2024

BACKGROUND

Diabetes self-management education programs have been shown to improve patients' health outcomes, and internet technology have provided more ways for management. However, it is difficult for patients to grasp all the information during a short period of consultation time.

OBJECTIVE

In this study, we implemented a fully integrated regional diabetes management model that information platform-based personalized prescription, and evaluated its feasibility and effectiveness among patients with T2DM.

METHODS

This was a 12-month long, multi-centered, prospective, and open-labeled cohort study. In this study, 1452 eligible participants with T2DM were enrolled and randomized to an intervention (n=726) or a control (n=726) group from April 2021 to April 2022. All patients underwent integrated management through an information platform. The intervention group was provided individualized self-management prescriptions, while the control group received routine care.

RESULTS

The intervention group showed significant HbA1c and PFG reduction (1.92% and 3.23mmol/L) at the first follow-up time, and 57% HbA1c (373) and 68% PFG (474) patients reached treatment target rate, compared with the control group (HbA1c =1.31%,26% (179) and FPG=2.31mmol/L, 39% (265). The co-primary outcomes were achieved by 119 people (18%) in the intervention group, and this was significantly higher than the control group (38 (6 %), P < 0.001). Moreover, the achieved co-primary outcomes rate is higher among middle-aged (19%) and female (19%) patients in the intervention group.

CONCLUSIONS

The platform-based diabetes self-management prescriptions provided feasible and effective in the management of T2DM, justifying their integration into clinical practice, with cholesterol management needs to be improved.
Consumers' concerns about eating out and food hygiene during the COVID-19 pandemic in Japan: a web-based questionnaire survey (Preprint)
Authors: Matsumoto Shinya , Kanagawa Yoshiyuki , Nagoshi Kiwamu , Imamura Tomoaki , Akahane Manabu
Published: December 2024

BACKGROUND

Coronavirus disease 2019 (COVID-19) began spreading globally in late 2019, impacting Japan by early 2020. Restrictions were imposed on social activities, international travel, and work setup, and restrictions on eating out were recommended. The infection was believed to spread through droplets, with the first cluster reported on a pleasure boat. To prevent transmission, the government advised avoiding the "three Cs" (closed spaces, crowded places, and close-contact settings), increasing public anxiety about eating at restaurants.

OBJECTIVE

This study aimed to examine the impact of the COVID-19 pandemic on consumer behavior and attitudes toward food and eating out in Japan, focusing on factors associated with dining-related anxiety.

METHODS

An online survey was conducted in January 2021 with 1,442 Japanese participants aged 10–70 years. The survey collected data on dining habits, food safety concerns, and demographic information, including personality traits. Principal component analysis was applied to responses regarding "concerns about eating during the COVID-19 pandemic." Univariate and multivariate regression analyses were used to extract key factors contributing to these concerns.

RESULTS

The study found that people were more anxious about eating at restaurants than at home or high-end establishments. Buffet-style meals, drink bars, and unwrapped disposable chopsticks were perceived as particularly risky. The first principal component of the principal component analysis had the same signs. The second principal component appeared at the opposite ends of the scale, with homes and buffets, event venues, and bars. Univariate linear regression analysis revealed items related to COVID-19. Multivariate linear regression showed not only items related to infection but also items related to food poisoning.

CONCLUSIONS

In Japan, the COVID-19 pandemic has significantly affected consumer behaviors and attitudes toward food and dining. While concerns about eating at home and high-end restaurants were relatively low, anxiety about buffet-style dining, drink bars, and unwrapped chopsticks was higher. Individuals concerned about eating out were more likely to prioritize infection control and food safety measures. Overall, the pandemic has led to a decline in restaurant visits and to preferences for home-cooked meals. Understanding these behavioral changes is crucial for the food industry to align with evolving consumer expectations in the post-pandemic era.
Research hotspots and trends in bone cancer pain: a bibliometric analysis from 1994--2023 (Preprint)
Authors: jinzhao huang , kan houming , lu ping , wang chi , shen wen
Published: December 2024

BACKGROUND

Bone cancer pain is caused primarily by the invasion of bone tissues and surrounding structures, such as nerves and blood vessels, by primary bone tumors or metastatic bone tumors, which poses significant challenges for both patients and healthcare providers. However, there is currently no effective treatment for BCP.

OBJECTIVE

In the last few years, there has been an increasing amount of research on bone cancer pain, and by analyzing and visualizing the literature on this topic, our objective has been to gain an understanding of the current state of research and the major issues in this field. This will allow us to make informed predictions about the future trajectory of research in this area.

METHODS

Relevant literature in the field of bone cancer pain was retrieved from the Web of Science core ensemble search, relevant literature in the field of bone cancer pain was retrieved, and then Citespace, Gunnmap online world maps and Microsoft Excel 2020 were used for bibliometrics and visualization analysis.

RESULTS

A total of 1976 WoS core databases were included. The visual analysis results indicate a year-over-year increase in the number of publications. Pain is the most influential journal (981 cocitations). The most productive nations and organizations were China (666) and Huazhong University of Science and Technology (54), respectively. Yao Ming (18) was the most prolific author, and Robert E Coleman (477 cocitations) was the most influential author. Bone metastases resulting from breast cancer, as well as the mechanisms of bone cancer pain, are currently hot topics of research.

CONCLUSIONS

The studies conducted thus far have demonstrated that the peripheral mechanisms implicated in the genesis of bone cancer pain encompass the tumour microenvironment, bone tissue damage, peripheral nerves and dorsal root ganglion sensitisation. However, there is a paucity of research investigating the role of the central nervous system in this phenomenon. Furthermore, there is a need to explore more efficacious treatments to further optimise the clinical management of patients with bone cancer pain.
Assessment of cognitive function in patients with metabolic dysfunction-associated steatotic liver disease
Authors: Komarytsia O.Y. , Radchenko O.M. , Huk-Leshnevska Z.O. , Stadnik S.M.
Published: December 2024

Background. Since the relationship between the initial stage of steatotic liver disease and dementia and cognitive function (CF) remains undetermined, there is a need to study such a combination. The aim is to evaluate CF in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Materials and methods. Thirty-nine outpatients with chronic forms of coronary heart disease were examined: 26 made up the main group with concomitant MASLD and 13 patients were included in the control group with an intact liver. In all of them, CF was evaluated using the Mini-Mental State Examination (MMSE). Results. The CF according to the MMSE was lower in patients with MASLD than among those with an intact liver (25.27 vs 28.22; p < 0.01). Mild cognitive disorders were diagnosed in 7.69 %, moderate — in 65.38 %, and severe — in 26.93 % of patients with MASLD. In total, the frequency of deterioration of CF (MMSE ≤ 27) among patients with an intact liver was 33.33 %, while it was significantly higher (92.31 %) in patients with concomitant MASLD (p < 0.05). Conclusions. CF can be an important criterion of the state of health and its changes, determines the course of the disease, allows assessing the activity of the endogenous intoxication syndrome and the state of the cardiovascular system. Impairment of cognitive functions occurs already at the stage of liver steatosis, which should be taken into account in the clinic.
Efficacy and safety of edoxaban in patients with cardioembolic stroke
Authors: Flomin Y.V. , Tsyhanii A.V. , Chervonopyska O.M. , Hetman T.V. , Honchar A.V.
Published: December 2024

Ischemic strokes due to cardiogenic embolism are associated with an increased risk of death or permanent disability, which emphasizes the importance of their prevention. Edoxaban is a Xa inhibitor that is widely used globally as a new oral anticoagulant to prevent thromboembolic complications in patients with atrial fibrillation and an increased risk of stroke. The purpose of this review is to summarize data on the efficacy and safety of edoxaban in the secondary stroke prevention. The literature review was conducted using PubMed and Medscape databases to search for publications on clinical trials and clinical guidelines on oral anticoagulant treatment for stroke prevention. The results of clinical trials show that in patients with atrial fibrillation, edoxaban is non-inferior to warfarin in efficacy for primary and secondary stroke prevention, but compared to warfarin, edoxaban treatment is much safer (significantly reduces the risk of serious bleedings, including intracranial ones). The safety profile of edoxaban makes it one of the best drugs for the treatment of elderly patients and those with chronic kidney disease. In general, the results of recent clinical trials indicate that in cardioembolic stroke due to atrial fibrillation, the early initiation of treatment with direct oral anticoagulants is safe and reduces the risk of recurrent embolic events. Timely determination of the etiological subtype of ischemic stroke, in particular the detection of paroxysmal atrial fibrillation, and consideration of individual patient characteristics are the key to an optimal secondary prevention strategy that minimizes the risk of recurrent brain damage and improves the quality of life after stroke.