bluuebunny/crossref_metadata_2025 huggingface dataset:
Bizon – UGV for Airport Pavement Testing. Mechanics and Control.
Authors: Stepien Slawomir Jan , Chodnicki Marcin , Nowakowski Miroslaw , Pietruszewski Paweł , Wesołowski Mariusz , Dobrowolski Damian
Published: February 2024

In the paper, a study of the performance of unmanned ground vehicle (UGV), establishes numerical simulation model of the chassis system by three-dimensional software and finite element analysis software. Based on the numerical modelling and analysis, the work focuses on study of the strength and stiffness of the vehicle's chassis and researched the distribution of stress and deformation under the extremal condition. The paper also presents an autopilot design with new cascade control system for an autonomous motion of an unmanned ground vehicle based on Proportional-Integral-Derivative (PID) and Feed-Forward (FF) control. The PID-FF controller is a part of dedicated for presented UGV used in a hybrid control system for precise control and stabilization, necessary to increase the vehicle motion stability and maneuvers precision. The hybrid PID-FF control system proposed for the ground vehicle model gives a satisfactory quality of control, while maintaining the simplicity of the control system. Presented tests performed in area of mechanical design and control analysis gives good results and proves usefulness of designed unmanned device.
Advanced Diagnostic and Therapeutic Endoscopy for Early Gastric Cancer
Authors: Fujishiro Mitsuhiro
Published: February 2024

Advances in gastric cancer screening and endoscopic technology have made it possible to detect and treat gastric cancer at an early stage. As a result, about 40% of all gastric cancers have now been resected by endoscopic treatment in Japan. In endoscopic diagnosis, magnifying endoscopic observation using band-limited light such as narrow band imaging (NBI) has significantly improved the accuracy of gastric cancer diagnosis. At the same time, in endoscopic treatment, endoscopic submucosal dissection (ESD) has contributed to increase explosively the number of gastric cancers which could be resected endoscopically. In recent years, the construction of algorism for endoscopic diagnosis and treatment with a view to personalized medicine has been explored, and endoscopic use for gastric cancer managements is expected to develop further in the future.

Keywords (5 words):
Filamentous Fungi as Bioremediation Agents of Industrial Effluents: A Systematic Review
Authors: Rosa Fernanda Maria , Mota Thaís Fernandes Mendonça , Busso Cleverson , Arruda Priscila Vaz de , Brito Patrícia Elena Manuitt , Miranda João Paulo Martins , Trentin Alex Batista , Dekker Robert F. H. , Cunha Mário Antônio Alves da
Published: February 2024

The industrial sector plays a crucial role in driving global economic growth by creating employ-ment opportunities, generating local income, and significantly contributing to each country's Gross Domestic Product (GDP). However, the manufacturing industry is responsible for produc-ing a substantial amount of polluting effluents, which can harm the environment and compromise the life quality of future generations if not appropriately treated. Various methods, including physical, chemical, and biological processes, have been employed in the treatment of industrial ef-fluents. Filamentous fungi, in particular, have garnered attention as effective bioremediation agents due to their ability to produce enzymes capable of degrading recalcitrant compounds and adsorb different pollutant molecules. This study aimed to assess the collective body of research on using white and brown rot fungi to remove phenolic compounds from industrial effluents. The research employed a systematic review, incorporating scientometric analysis, with the primary goal of constructing a comprehensive overview of the evolution of this technology over time. The analysis also aimed to scrutinize its geographical distribution and identify gaps and trends within these research inquiries. Data for the study were obtained from the Web of Science (WoS) data-base using specific search terms (("white rot fung*" OR "brown rot fung*") AND (phenol* OR phenoloxidase OR "polyphenol oxidase*") AND (wastewater OR effluent* OR bioremediation)). The time frame considered ranged from 1945 to 2023, resulting in 464 publications. After refine-ment, 109 studies were selected for further analysis, focusing on using filamentous fungi in the bi-oremediation of industrial effluents. The findings revealed that white rot fungi were the most studied in industrial effluent remediation processes, accounting for 96.3% of the studies assessed, followed by brown rot fungi at 2.7%. Filamentous fungi demonstrate significant potential for treating industrial effluents due to their high capacity to degrade phenolic compounds, especially in wastewater from olive mills, paper production industries, and distilleries. Among the investi-gated species, Phanerochaete chrysosporium, Pleurotus ostreatus, Trametes versicolor, and Lentinula edodes have been the most extensively researched for this application. Notably, cultures with free cells (64.15%) stood out compared to cultures with immobilized cells, and cultures with isolated fungi surpassed microbial consortia. Geographically, Italy, Spain, Greece, India, and Brazil emerged as the most prominent countries in publications related to this area during the evaluated period.
Confinement of a Styryl Dye into Nanoporous aluminophosphates: Channels vs Cavities
Authors: Oliden-Sánchez Ainhoa , Sola-Llano Rebeca , Pérez-Pariente Joaquín , Gómez-Hortigüela Luis , Martínez-Martínez Virginia
Published: February 2024

Styryl dyes are generally poor fluorescent molecules inherited from their flexible molecular structures. However, their emissive properties can be boosted by restricting their molecular motions. A tight confinement into inorganic molecular sieves is a good strategy to yield highly fluorescent hybrid systems. In this work, two Mg-aluminophosphate zeotypes (AEL framework, a one-dimensional channeled structure with elliptical pores of 6.5 Å x 4.0 Å; and CHA framework, composed by large cavities of 6.7 Å x 10.0 Å connected by 8-ring narrower windows) were selected for the encapsulation of 4-DASPI dye (trans-4-[4-(Dimethylamino)styryl]-1-methylpyridinium iodide). The synthesis and photophysical properties of 4-DASPI styryl dye occluded within these two types of confinements, AEL and CHA, are optimized and analyzed. The resultant hybrid systems display significantly improved photophysical features compared to 4-DASPI in solution. Molecular simulations reveal a tighter confinement of 4-DASPI in the elliptical channels of AEL, whilst a particular orientation is found within the CHA framework, where one 4-DASPI molecule spans along two adjacent cavities. In the latter scenario, each aromatic ring is positioned on these adjacent cavities and the polymethine chain resides within the 8-ring window, being this confinement slightly less tight than for AEL.
Reduction of Scrap in Electric Motor Manufacturing for the Automotive Industry: A case study using PDCA Approach
Authors: Rangel-Sanchez Miguel-Angel , Urbina-González José-de-Jesús , Carrera-Escobedo Jose-Luis , Guirette-Barbosa Omar-Alejandro , Murillo-Rodriguez Virgilio-Alfonso , Celaya-Padilla José-María , Durán-Muñoz Héctor-Antonio , Cruz-Domínguez Oscar
Published: February 2024

The dynamic global automotive sector is characterized by an ever-evolving demand for high-quality vehicles and accessible prices. This research tackles the issue of scrap reduction in electric motor manufacturing for the automotive industry, specifically in a Chinese company, by employing the PDCA methodology. The paper delves into the company's background and current landscape, while pinpointing the problem: specific production lines segments experiencing hi-pot issues are the primary source of scrap. The overarching goal is to design and implement a strategy that, leveraging the PDCA approach, reduces scrap generated during the eight-months subassembly (armature) manufacturing process, from its current average of 2.92% to 0.7%, ultimately enabling the company to eliminate hi-pot defects.
Efficacy of gonadotropin-releasing hormone antagonists in the management of patients with severe early-onset ovarian hyperstimulation syndrome
Authors:   Al-Azhar University, Egypt, Hussein M. , Alboghdady M.A. ,   Al-Azhar University, Egypt, Almorsy A.S. ,   Al-Azhar University, Egypt, Hamed W.M. ,   Al-Azhar University, Egypt, Saleh M. ,   Al-Azhar University, Egypt, Fathi M.K. ,   Al-Azhar University, Egypt, Ellaban M. ,   Al-Azhar University, Egypt, Abdallah K. ,   Al-Azhar University, Egypt, Samir Hamid A. ,   Al-Azhar University, Egypt, Fekry H. ,   Al-Azhar University, Egypt, .Awad A.M. ,   Al-Azhar University, Egypt, Abdel Razek Emam O.A. ,   Ain Shams University, Egypt
Published: February 2024

Objective. To study the efficacy of gonadotropin-releasing hormone (GnRH) antagonists in the treatment of patients with severe early-onset ovarian hyperstimulation syndrome (OHSS). Patients and methods. This study including 60 women was conducted between January 2021 and January 2023 at Al-Azhar University Maternity Hospitals and private ART centers. Approval from the Research Ethics Committee was obtained to conduct the study. Patients were randomly divided into two groups: group I (n = 30; control group) received only standard therapy for severe OHSS, group II (n = 30; study group) received standard therapy and cetrorelix. Results. The percentage of patients who required paracentesis, the mean serum creatinine level 48 hours after GnRH antagonist injection, and the percentage of patients who had persistent oliguria 48 hours after GnRH antagonist injection were significantly lower in the study group (cetrorelix group) compared with the control group. Patients in the cetrorelix group had a significantly shorter mean length of hospital stay and mean recovery time than patients in the control group. Conclusion. The therapeutic efficacy of the GnRH antagonist cetrorelix for the treatment of patients with severe early-onset OHSS was demonstrated. Key words: gonadotropin releasing-hormone antagonist; severe early-onset ovarian hyperstimulation syndrome
Risk factors for intrauterine fetal demise in pregnant women with complicated obstetric history and COVID-19 during pregnancy
Authors:   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan, Urstemova K.K. ,   Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan, Bozhbanbaeva N.S. ,   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan,   Center of Perinatology and Pediatric Cardiac Surgery, Almaty, Kazakhstan, Boranbaeva R.Z. ,   Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan, Tarabayeva A.S. ,   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan, Bitanova E.Zh. ,   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan, Abilbayeva A.A. ,   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan, Suleymenova I.E. ,   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan,   Center of Perinatology and Pediatric Cardiac Surgery, Almaty, Kazakhstan
Published: February 2024

Objective. To investigate the significance and prognostic value of risk factors for intrauterine fetal demise (IUFD) in women with complicated obstetric history (COH) who had COVID-19 in the second and third trimesters of pregnancy. Patients and methods. A retrospective study of 5027 medical records of pregnant women, postpartum women and neonates who received treatment in obstetric institutions in Almaty with positive PCR results for SARS-CoV-2 in the second and third trimesters of pregnancy was conducted. IUFD occurred in 46 (0.9%) pregnant women. Results. The risk of IUFD increased with prolongation of COVID-19 treatment during pregnancy (OR = 8.673, 95% CI: 4.252-17.692), in the absence of therapy with low-molecular-weight heparin (OR = 4.835, 95% CI: 2.471-9. 459) and was also characteristic of moderate and severe COVID-19 (OR = 4.2667, 95% CI: 1.0603-17.1689), with history of maternal anemia and acute respiratory viral infections (ARVI) (OR = 3.524, 95% CI: 1.643-7.559 and OR = 4.117, 95% CI: 1.881-9.010, respectively). Meanwhile, the absence of antibiotic and corticosteroid therapy was associated with a lower risk of IUFD (OR = 0.415, 95% CI: 0.184-0.937 and OR = 0.278, 95% CI: 0.142-0.547, respectively). Conclusion. The risk of IUFD in pregnant women with COH and COVID-19 during pregnancy increased significantly with the duration of COVID-19 treatment, with moderate and severe course, and with the deficiency of anticoagulant therapy. At the same time, the absence of glucocorticosteroids and antibacterial agents showed a negative association with IUFD. Key words: intrauterine fetal demise, antibiotic therapy, anticoagulants, pregnancy, glucocorticosteroid therapy, COVID-19
Early- and late-onset fetal growth restriction. Risk factors and complications in the early neonatal period
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ignatko I.V. , Bogomazova I.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Timokhina E.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Belousova V.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Zavyalov O.V. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation,   Central State Medical Academy of the Presidential Administration of the Russian Federation, Moscow, Russian Federation, Alieva F.N. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Melek M.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Romanova E.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Papko K.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

Objective. To study clinical and anamnestic risk factors for the development of complications during the early neonatal period in early- and late-onset fetal growth restriction (FGR). Patients and methods. This study included 92 patients: 40 with early-onset FGR and 52 with late-onset FGR. The age aspect, medical records, pregnancy and delivery characteristics, complications in the early neonatal period were examined in all patients. Results. Most patients with FGR had complicated somatic and obstetric/gynecological histories. Patients with early-onset FGR were more likely to have chronic arterial hypertension, spontaneous abortion, missed miscarriage, and uterine surgeries. In the first and second trimesters of pregnancy, only patients with early-onset FGR had elevated blood pressure. In the third trimester, patients with early-onset FGR were significantly more likely to develop pre-eclampsia and its complications than patients with late-onset FGR. Patients with early-onset FGR delivered earlier than patients with late-onset FGR, which affected the early neonatal period. Conclusion. The presence of hypertensive complications starting early in pregnancy and the results of biochemical screening tests should be considered as part of the prediction of FGR. Timely diagnosis, treatment and prevention of gestational complications will improve maternal and perinatal outcomes. Key words: gestational arterial hypertension, fetal growth restriction, late-onset fetal growth restriction, pre-eclampsia, earlyonset fetal growth restriction, chronic arterial hypertension
Calcium and its synergists in the context of perimenopause
Authors:   Federal Research Center ", Gromova O.A. ,   Computer Science and Control",   , Russian Academy of Sciences, Moscow, Russian Federation, Torshin I.Yu. ,   Federal Research Center "Computer Science and Control", Russian Academy of Sciences, Moscow, Russian Federation
Published: February 2024

Bone metabolism disorders during menopause, which occur against the background of decreasing estrogen levels, stimulate the early development of osteopenia and osteoporosis. Bone homeostasis disorders in menopause may be impacted by a variety of causes, including (1) metabolic disorders of other types of connective tissue (in particular, joints, ligaments, skin and its appendages), (2) complex hormonal imbalance (including insulin resistance), (3) deficiency of osteotropic macro- and microelements (calcium, magnesium, copper, zinc, boron, etc.). Measurements of blood levels of these elements are informative biomarkers for assessing bone health in patients, and supplementation with these elements is an effective therapeutic strategy for osteoporosis and other connective tissue disorders in perimenopausal women. Key words: menopause, bone homeostasis, osteopenia, osteoporosis, Calcemin Advance
Experience of using metaprebiotic products in the nutrition of children with constipation
Authors:   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Safronova A.I. , Pyrieva E.A. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Timoshina M.I. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Toboleva M.A. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Kolodkin A.M. ,   Scientific Society “Microbiota”, Moscow, Russian Federation
Published: February 2024

Objective. To evaluate the effect of metaprebiotic products on the state of intestinal function in children with neurological pathology. Patients and methods. This study included 32 children with neurological pathology suffering from chronic constipation and gut microbiota dysbiosis: 13 boys and 19 girls aged between 6 months and 6 years (mean age: 4.6 ± 1.6 years). Patients were divided into a study group and a comparison group. The study group received a specialized product with metaprebiotic properties in addition to the standard diet for 14 days. Anthropometric characteristics, product tolerance, including stool frequency and consistency, were evaluated, and the metabolic activity of anaerobic bacteria was analyzed based on the concentrations of short-chain fatty acids (SCFAs) in stool samples by gas-liquid chromatography. Results. In the study group, stool frequency increased from 0.61 ± 0.25 times per day at the beginning of the study to 0.93 ± 0.11 times per day at the end of the study (p < 0.05) against the background of metaprebiotic product application. In the comparison group, stool frequency did not change statistically significantly (0.7 ± 0.19 and 0.85 ± 0.15 times per day at the beginning and end of the study, respectively). Children in the study group showed an increase in the absolute concentrations of C2-C4 SCFAs (p < 0.05). No statistically significant changes were found in both absolute and relative concentrations of individual SCFAs (acetic, propionic, and butyric acids) in any of the groups. Conclusion. The results of this study showed the effectiveness of a specialized food product with metaprebiotic properties based on inulin and oligofructose containing calcium lactate in the correction of intestinal function in children with neurological pathology. Key words: children, constipation, inulin, oligofructose, prebiotics, specialized food products
Non-alcoholic (metabolic associated) fatty liver disease in children with inflammatory bowel disease: current state of the problem
Authors:   Kazan State Medical University, Kazan, Russian Federation, Kamalova A.A. ,   Children’s Republican Clinical Hospital, Kazan, Russian Federation, Gaifutdinova A.R. ,   Kazan State Medical University, Kazan, Russian Federation, Safina E.R. ,   Kazan State Medical University, Kazan, Russian Federation, Garina G.A. ,   Kazan State Medical University, Kazan, Russian Federation
Published: February 2024

Non-alcoholic fatty liver disease (NAFLD) is becoming a common disease in both adults and children. Considering its multifactorial nature, a term “metabolically associated fatty liver disease” has been proposed, and new diagnostic criteria have been formulated to identify risk groups and to suspect the disease at early stages. Inflammatory bowel disease (IBD) is often associated with hepatobiliary manifestations. The prevalence of NAFLD among IBD patients is higher than in the general population, which is related to additional risk factors, such as history of previous intestinal surgery, long-term corticosteroid therapy, IBD severity and duration, parenteral nutrition, and sarcopenia. NAFLD can be combined with other liver pathologies, complicating them and worsening the course of IBD. NAFLD has an asymptomatic course and is often detected at late stages due to diagnostic difficulties. Clinical guidelines for the management of NAFLD in children with IBD have not been developed. The gold standard for diagnosis is liver biopsy with histological examination. Non-invasive methods of NAFLD diagnosis are being studied, including transient elastography and magnetic resonance imaging (MRI)-estimated proton density fat fraction (PDFF). In treatment, the first place is given to non-pharmacological methods: changing dietary habits, increasing physical activity. Data on pharmacological treatment methods are currently contradictory and continue to be studied. Key words: inflammatory bowel disease, non-alcoholic fatty liver disease, metabolically associated fatty liver disease
Experience of using glucagon-like peptide-2 analog in a child with short bowel syndrome
Authors:   Children’s Republican Clinical Hospital, Kazan, Republic of Tatarstan, Russian Federation, Sageeva G.I. , Podshivalin A.A. ,   Children’s Republican Clinical Hospital, Kazan, Republic of Tatarstan, Russian Federation, Druzhkova E.E. ,   Kazan State Medical University, Kazan, Republic of Tatarstan, Russian Federation, Kamalova A.A. ,   Children’s Republican Clinical Hospital, Kazan, Republic of Tatarstan, Russian Federation,   Kazan State Medical University, Kazan, Republic of Tatarstan, Russian Federation, Akhmadeeva A.A. ,   Children’s City Polyclinic No 9, Kazan, Republic of Tatarstan, Russian Federation, Khayalutdinova L.R. ,   Children’s City Polyclinic No 7, Kazan, Republic of Tatarstan, Russian Federation
Published: February 2024

This article presents a clinical case of ultra-short bowel syndrome. The development of the underlying disease and comorbid disorders are described in dynamics, difficulties and therapeutic options are discussed. This clinical case reflects the real practice of managing a child with a rare disease using current possibilities of pharmacotherapy. Key words: short bowel syndrome, nutritional status, intestinal adaptation, glucagon-like peptide-2 analog
Causes of exclusive breastfeeding failure in a sample from a primary healthcare center in Baghdad, Iraq
Authors:   Sulayman Al-Faydhi Primary Healthcare Center, Al-Russafa Health Directorate, Baghdad, Iraq, Kadum N.S. , Al-Shatari S.A. ,   Department of Total Quality Management & Institutional Development, Office of the Minster, Iraqi Ministry of Health, Iraq, Mahdi S.A. ,   Al-Turath University, Baghdad, Iraq, Alshewered A. ,   Misan Radiation Oncology Center, Misan, Iraq
Published: February 2024

Exclusive breastfeeding (EBF) is essential for the health of infants and mothers. Despite this, EBF failure is a common problem all over the world. Objective. To determine the causes of EBF failure in a sample from a primary healthcare center (PHС) in Baghdad city, Iraq. Patients and methods. A cross-sectional study was conducted at Sulayman Al-Faydhi PHC in Hay Albenouk district (Baghdad, Iraq) between August 1 and October 1, 2019. It included 222 mothers who failed to achieve EBF and their healthy infants under 6 months of age. All of these mothers had previously visited antenatal care providers. Results. Out of the total number of cases, 118 (53.3%) children were male, 73 (32.9%) children were first born, and most of them (170 (76.6%)) were delivered by cesarean section. Regarding the age of mothers, 68 (30.6%) of them were between 25–29 years old, and the level of education was secondary in 102 (45.9%). Most of these mothers (165 (74.3%)) failed to exclusively breastfeed their children during the first month after delivery, and 211 (95%) of them had no or poor knowledge about EBF. They mentioned many causes of EBF failure and the most common was low milk supply in 92 (41.4%). The second major cause was the prescription of formula milk in 65 (29.3%). Only 10 (4.5%) mothers mentioned child-related reasons such as prematurity and hospitalization. Conclusion. Beliefs about low milk supply and formula milk prescription were the main causes of EBF failure. This study showed that most mothers have little or no knowledge about EBF. Key words: exclusive breastfeeding, primary health care, infant
COVID-19 and chronic gastrointestinal pathology: clinical presentation, management, and outcomes
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Savvateeva O.A. , Gorelov A.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Pechkurov D.V. ,   Samara State Medical University, Samara, Russian Federation, Romanova A.A. ,   Samara State Medical University, Samara, Russian Federation, Savvateev A.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

National and international clinical guidelines provide detailed information on the diagnosis and treatment of COVID-19 infection, but long-term damage to multiple organs and systems associated with the disease, especially in patients with aggravated premorbid history, is still barely understood. The digestive system appears to be a sensitive target for SARS-CoV-2, and there is evidence of long-term persistence of the virus in the gastrointestinal (GI) tract without its detection in the respiratory system. A quarter to half of COVID-19 patients have GI symptoms, which are associated with a more severe disease course. The virus can affect any part of the digestive system, and people with underlying GI diseases are at greatest risk for adverse outcomes. The probability of having a post-infectious pathology is evident, but of practical interest is the impact of current or past COVID-19 infection on the course of gastrointestinal pathology. Some patients with chronic GI diseases are more likely to develop COVID-19 disease. In these patients, it is difficult to diagnose the infectious process, and there is a risk of a more severe course and adverse outcomes of COVID-19. In this regard, the management of comorbid patients requires certain adjustments to standard treatment regimens for novel coronavirus infection. Key words: COVID-19, gastrointestinal pathology, children, post-COVID syndrome
Sarcopenic obesity in children: clinical significance, approaches to diagnosis and treatment
Authors:   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Pavlovskaya E.V. , Bagaeva M.E. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Zubovich A.I. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Strokova T.V. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Starodubova A.V. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: February 2024

Sarcopenic obesity (SO) is a functional and clinical condition characterized by excess fat mass and low skeletal muscle mass (sarcopenia). The double negative effect of obesity and sarcopenia on human health is manifested by a high risk of developing numerous chronic non-communicable diseases and low therapeutic effectiveness. It was previously believed that SO develops predominantly in older adults, however its prevalence in children has increased over the last decade. To date, there is no standard diagnostic criteria for SO. In contemporary pediatric practice, measurements of muscle mass quantity and quality are used to detect SO. In adults, physical performance is assessed in addition to muscle mass in the diagnosis of sarcopenia. Approaches to the treatment of SO in children are limited to non-pharmaceutical methods, with adequate protein intake and strength and aerobic training being the most important. This review summarizes the current understanding of the prevalence, pathogenesis, and clinical significance of SO in children, as well as the methods of its diagnosis and treatment. Key words: obesity, sarcopenia, children, adolescents, muscle mass
Association of celiac disease and Crohn’s disease
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Mustafina A.F. , Mytnik M.K. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Kramskikh S.I. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Shumilov P.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Demyanova T.G. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Khandamirova O.O. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Kostomarova E.A. ,   N.F.Filatov Children’s City Clinical Hospital, Moscow, Russian Federation, Grebennikova M.A. ,   N.F.Filatov Children’s City Clinical Hospital, Moscow, Russian Federation
Published: February 2024

The incidence of immune-mediated diseases in children is increasing worldwide. The prevalence of Crohn’s disease reaches 11.4 cases per 100,000 people. The estimated incidence of celiac disease in Russia is 1:100–1:250. The association of Crohn’s disease and celiac disease is quite common. Celiac disease is associated with an 11-fold increase in the risk of inflammatory bowel disease (IBD) compared to control populations; patients with IBD have a 2-fold increased risk for developing celiac disease. This may be due to similarities in pathogenesis. Identical ultrastructural changes in the intestinal mucosa were found in the form of impaired expression of transmembrane proteins (claudin-2, claudin-3, claudin-4, occludin) and cytoplasmic tight junction proteins (zonulin). Celiac disease and Crohn’s disease share many similarities, including in T cell inflammation. Levels of the cytokines IL-17, IL-21, and IFN-γ are elevated in both celiac disease and Crohn’s disease, with high levels of IL-15 being associated only with celiac disease. This article presents a clinical case of Crohn’s disease coexisting with celiac disease in an adolescent. Key words: Crohn’s disease, celiac disease, inflammation, children
Current approaches to the diagnosis and management of patients with Prune belly syndrome
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Khokhlova A.P. , Sarkisyan H.A. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation,   G.N.Speransky Children’s City Clinical Hospital No.9, Moscow, Russian Federation, Shumilov P.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Samorokovskaya M.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation,   G.N.Speransky Children’s City Clinical Hospital No.9, Moscow, Russian Federation, Makulova A.I. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation,   G.N.Speransky Children’s City Clinical Hospital No.9, Moscow, Russian Federation, Kucherov Yu.I. ,   G.N.Speransky Children’s City Clinical Hospital No.9, Moscow, Russian Federation
Published: February 2024

Prune belly syndrome (PBS) is a congenital disorder that is characterized by hypoplasia (aplasia) of the anterior abdominal wall muscles, various urinary tract anomalies, and bilateral cryptorchidism. The prevalence of PBS is approximately 1:40,000-1:45,000, and it is commonly diagnosed in male neonates. The possible genetic determinism of the disease is explained by the identification of 14 mutations in live-born children with PBS. Fetal ultrasound allows the diagnosis of PBS at 12 weeks’ gestation. In prolongation of pregnancy, along with specialized care and intensive care in neonatal units, renal replacement therapy, children with PBS need correction of diagnosed malformations and concomitant surgical pathology. This article presents current features of a multidisciplinary approach to the diagnosis and management of patients with this pathology to timely correct the condition and improve long-term outcomes. Key words: prune belly syndrome, megacystis, megaureter, cryptorchidism, abdominal muscle hypoplasia, wrinkled abdominal wall, renal replacement therapy
Severe course of celiac disease complicated by stress-induced hyperglycemia
Authors:   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan, Usmonova K.Sh. , Kamilova A.T. ,   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan, Dustmukhamedova D.Kh. ,   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan, Makhmudov A.S. ,   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan
Published: February 2024

This article presents a clinical case of lately diagnosed celiac disease complicated by stress-induced hyperglycemia. A 2-yearold patient was admitted to the intensive care unit of the Republican Specialized Scientific and Practical Medical Center of Pediatrics with severe protein-energy malnutrition, lethargy, abdominal bloating, and constipation. On admission, the child had hypoproteinemia, hypoalbuminemia, blood glucose levels up to 11.7 mmol/L, and anemia. On the third day of illness, blood glucose levels reached 16 mmol/L, which was considered as stress-induced hyperglycemia. Glucose levels were reduced by insulin injections on day 9. Celiac disease was suspected based on complaints, anamnestic, clinical and laboratory findings. Examination revealed elevated levels of IgA antibodies to tissue transglutaminase, exceeding the reference values 15 times. Genetic study confirmed the presence of predisposition to the disease. Catamnestic follow-up demonstrated a positive effect of a gluten-free diet. This is the first description of a typical form of celiac disease with late diagnosis and complications such as stress-induced hyperglycemia, respiratory failure, protein-energy malnutrition, and protein-losing enteropathy. Early diagnosis is very important to prevent long-term complications. Key words: children, malabsorption, celiac disease, stress hyperglycemia, protein-losing enteropathy
Brexit Sonrası Kuzey İrlanda ve AB İlişkilerinde Güvenliğin Dönüşümü: Canlanan Tarihsel Sorunlar
Authors: Tütmez Elif Dilan , Kalkan Erol
Published: February 2024

Uzun bir tarihsel geçmişe sahip olan Kuzey İrlanda (Kİ) sorunu, Birleşik Krallık’ın Avrupa Birliği’nden (AB) ayrılmasıyla tekrar gündeme gelmiştir. Eski Başbakan David Cameron tarafından başlatılan Brexit (İngiliz çekilmesi), Haziran 2016 referandumuyla kesinleşmiş ve Şubat 2020’de tamamlanmıştır. AB üyeliğinin Kİ ve İrlanda Cumhuriyeti’ni entegrasyon yoluyla bütünleştiren yapısı ortadan kalkmıştır. Kuzey İrlanda’da kırk yılı aşkın mezhep çatışmalarına son veren 1998 Belfast Antlaşması ise, Brexit’le tehlikeye girmiştir. Bu çalışmada Brexit’in Kuzey İrlanda’da ortaya çıkardığı tarihsel sorunlar ve güvenlikleştirilen alanlar analiz edilmektedir. Çalışmada Brexit kararının, Kİ eyaletlerinin ve sınır bölgelerinin istikrarına ve yenilenmesine katkıda bulunan toplumsal, ekonomik ve siyasi dengelerin sürdürülebilirliğine ilişkin güvenlik problemleri yarattığı savunulmaktadır. Keza güvenlikleştirilmiş sınırın, Kİ toplumu adına olumsuz deneyimleri ve gerilimleri çağrıştırdığı belirtilmektedir. Dolayısıyla çalışmada, Kİ sorununun tarihsel arka planı ve Brexit sonrası sürecin doğurduğu yeni koşullar dikkate alınarak, iki İrlanda’nın birleşme olasılığı ile Birleşik Krallık’ın ve AB’nin geleceğine etki eden dinamikler, güvenlikleştirme bağlamında analiz edilmektedir.
Dynamic Foot Pressure During Walking: A Potential Indicator of Bone Mineral Density
Authors: Choi Yoon Hyo , Choi Ji Hye , Koo Seungbum , Han Hee Soo , Lee Dong Yeon , Lee Kyoung Min
Published: February 2024

Background:

Physical skeletal loading can affect the bone mineral density (BMD). This study investigated the association between BMD and dynamic foot pressure during gait.

Methods:

A total of 104 patients (mean age, 62.6 ± 12.4 years; 23 male and 81 female) who underwent dual x-ray absorptiometry and pedobarography were included. BMD values of the lumbar spine, femoral neck, and total femur were assessed. The mean and maximum pressures were measured at the hallux, lesser toes, 1st metatarsal head, 2nd and 3rd metatarsal heads, 4th and 5th metatarsal heads, midfoot, medial heel, and lateral heel. Multivariable regression analysis was performed to identify factors significantly associated with BMD.

Results:

The lumbar spine BMD was significantly associated with the mean pressure at the 4th and 5th metatarsal heads (p = 0.041, adjusted R2 of model = 0.081). The femoral neck BMD was significantly associated with the maximum pressure at the 2nd and 3rd metatarsal heads (p = 0.002, adjusted R2 = 0.213). The total femoral BMD also showed a significant association with the maximum pressure at the 2nd and 3rd metatarsal heads (p = 0.003, adjusted R2 = 0.360).

Conclusions:

Foot plantar pressure during gait was significantly associated with BMD, and could potentially be used to predict the presence of osteoporosis.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Early Proterozoic Polymigmatites in a Zone of Granulite Metamorphism: P–T–X Conditions, Age, and Duration of Migmatization (Northern Ladoga Area, Russia)
Authors: Baltybaev Sh.K. , Yurchenko A.V. , Rizvanova N.G. , Vivdich E.S. , Galankina O.L. , Borisova E.B.
Published: February 2024

—Polymigmatites in the Early Proterozoic metamorphic complex of the Northern Ladoga area trace the evolution of thermodynamic conditions during anatexis. The P–T conditions inferred for anatectic leucosome correspond to the onset of partial melting under granulite facies conditions of 5.5–6.2 kbar and 720–810 °C. After the peak of metamorphism, pressure and temperature show a coupled decrease to 4 kbar and ~550 °C, respectively. The latest granitic veins were intruded into metamorphic rocks during an event of brittle deformation. The P–T trend correlates with changes in migmatitic mineral assemblages and in chemistry of minerals. Newly formed leucocratic material changed from plagiogranitic to granitic composition when melting involved plagiogneiss but melt derived from Al-rich metapelite remained granitic. The analyzed leucosomes and granitic veins originated by multistage melting, under P–T conditions changing from granulite to amphibolite facies, between 1875 and 1865 Ma. Judging by their ages, the leucosome and granitic vein bodies from the Lakhdenpokhia and Priozersky zones of the area differed in the total duration of crystallization. Therefore, a single thermal event involving different lithologies can produce intrusions of different ages.
Técnicas de distracción utilizadas en Odontopediatría para la atención de los niños de 5 a 10 años. Revisión de la literatura
Authors:   , Cuya Garcia Raysa Alejandrina
Published: February 2024

Introducción: Las técnicas de distracción son estrategias para manejar la conducta durante la consulta dental, las mismas que le permiten establecer una buena relación con su paciente. Objetivo: Revisar información actualizada relacionada a las técnicas de distracción utilizadas en odontopediatría para la atención de los niños de 5 a 10 años. Metodología: La estrategia de búsqueda fue efectuada en los siguientes repositorios: Scielo, PubMed, Scopus, Lilacs. Utilizándose como descriptores métodos y odontología y niño; técnicas, ansiedad y odontopediatría. Los criterios de selección implicaron artículos con criterios de calidad metodológica, artículos en idioma español e inglés, artículos con acceso completo, artículos en versión digital, artículos publicados entre Enero del 2017 y Julio del 2023. Resultados: Entre los hallazgos se halló que las actividades más usadas como medio distractor en niños eran: lentes audiovisuales 3D, música, aromaterapia y distracción lúdica, los cuales ayudaban a controlar la ansiedad y miedo, mejorar o mantener una conducta positiva en los niños durante la atención odontológica. Conclusiones: De acuerdo con la literatura revisada, las técnicas de distracción activa para niños de 5 a 10 años que se someten a un tratamiento odontológico se encuentran: lentes 3D (transmitir juegos o dibujos animados), música (sonidos alegres o relajantes) y en las actividades pasivas; se encuentran aromaterapia, distracción lúdica e hipnosis. Tanto las técnicas pasivas como las activas, son igual de efectivas como medio de distracción y pueden llegar a disminuir el estrés, miedo, dolor y ansiedad de los pacientes permitiendo la mejora de la conducta o mantenerla positiva.
Análisis bibliométrico de 10 años sobre tumores cerebrales tratados con radiocirugía Gamma Knife: visualización, características y tendencias científicas (2011-2020)
Authors:   , Garcia Fuentes Walkiria Maria , Espinoza Rodriguez Leonardo Alejandro
Published: February 2024

Antecedentes: El objetivo de este estudio fue describir las características bibliométricas de la producción científica sobre el tratamiento de tumores cerebrales con radiocirugía gamma knife en Scopus a través de un estudio retrospectivo que analiza publicaciones en los últimos 10 años. Métodos: Se utilizó la base de datos de Scopus (ElSevier), para recolectar todos los estudios relevantes para este análisis bibliométrico. Los datos se descargaron como un archivo .csv de Scopus y luego se exportaron a Microsoft Excel para la presentación mediante tablas y para un análisis más detallado, el archivo .csv se exportó a SciVal. Se analizó el número de documentos y citas para los más productivos países, instituciones, revistas y autores que publican documentos científicos sobre el uso de radiocirugía gamma knife para tumores cerebrales. Resultados: Se obtuvieron 458 metadatos de las publicaciones científicas, sobre las cuales se aplicó criterios de inclusión y exclusión, quedando 248 estudios. El pico máximo de publicaciones fue 2018 con 31 publicaciones y el pico mínimo fue 2015 con 18. Los subtemas más relacionados fueron neurología, cirugía y oncología y la mayoría de documentos recuperados solo tenía colaboración institucional. En cuanto a revistas más productivas, se encuentra primero Journal of Neurosurgery con 23 publicaciones, dentro de los países con mayores publicaciones científicas tenemos a Estados Unidos, Japón y China. Siendo Estados Unidos el país con más cantidad de producciones, University of Texas MD Anderson Cancer Center fue la principal universidad con mayor producción científica y Sheehan y Trifiletti, autores estadounidenses, dominan la lista con el mayor número de documentos. Conclusión: Se concluyó que la producción científica con respecto a cirugía gamma knife y tumores cerebrales ha ido en aumento durante los últimos 10 años, con una gran incidencia durante 2018 y la mayor cantidad de artículos publicados se ubicaron en el primer cuartil…
La falta de actuación jurídica de las partes en el proceso de demarcación territorial y la afectación económica a la comunidad Marancocha
Authors:   , Yupanqui Garcia Fredy Junior
Published: February 2024

En este artículo se mostrará cómo la falta de participación de las partes en el proceso de demarcación afecta económicamente a la comunidad de Marancocha. Se analizará cómo los derechos territoriales de las comunidades campesinas se ven afectados por la falta de acción jurídica y cómo esto repercute en su situación económica. Se desarrollará sobre cómo la Ley de Demarcación Territorial establece el proceso para resolver conflictos como estos y por qué no se aplicaron en nuestro caso. De igual forma se propondrá una alternativa de solución a los conflictos de demarcación territorial.
Computational Fluid Dynamics Modeling and Analysis of Axial and Radial Temperature of Wellbore during Injection and Production Process
Authors: Zheng Jie , Hu Zhihao , Wang Weixiao , Dou Yihua , Li Jiahui , Yang Xu , Zhang Yarong , Cao Yinping
Published: February 2024

To solve problems such as additional tubing/casing load, casing deformation, and packer failure caused by changes in annular temperature during oil and gas reservoir fracturing and production, based on the well structure of oil and gas reservoirs and transition transient heat transfer mechanism, a four-field coupling simulation model of the temperature field in the main fluid domain of the tubing, the temperature field in the solid domain of the tubing, the temperature field in the annular fluid domain, and the temperature field in the solid domain of the casing is proposed. Considering the coupling of fluid temperature, pressure, and physical parameters, boundary conditions are established based on reservoir characteristics, wellbore heat transfer characteristics, and fracturing and production conditions, and are compiled into Fluent software for simulation through the user-defined function (UDF) method. The effects of the temperature and flow rate of injected fracturing fluid and produced oil and gas on the distribution of the wellbore temperature field and temperature gradient are studied. The research results show that by applying D14-1 and D5-5 gas wells to the model, the simulated temperature is in good agreement with the measured wellbore temperature, and the maximum errors of the simulated values of the two different wells are 6.4% and 4.3%, respectively. As the injection and production operation time increase, the heat transfer between the wellbore and the formation gradually stabilizes. At this time, the injection and production flow rate have little impact on the wellbore temperature field, while the injection and production temperature have a greater impact on the wellbore temperature field. The injection and production temperature will cause changes in annular temperature and temperature gradient, leading to an increase or decrease in pressure within a limited annular volume, resulting in local stress on the tubing and casing. The research results can provide a theoretical basis for the analysis of the temperature field and pressure field of the wellbore during fracturing and oil and gas production, ensuring the safety and stability of fracturing and production.