bluuebunny/crossref_metadata_2025 huggingface dataset:
Active search strategies, clinicoimmunobiological determinants and training for implementation research confirm hidden endemic leprosy in inner São Paulo, Brazil
Authors: Bernardes Filho Fred , Silva Claudia Maria Lincoln , Voltan Glauber , Leite Marcel Nani , Rezende Ana Laura Rosifini Alves , de Paula Natália Aparecida , Barreto Josafá Gonçalves , Foss Norma Tiraboschi , Frade Marco Andrey Cipriani
Published: June 2021

Background

This study evaluates implementation strategies for leprosy diagnosis based on responses to a Leprosy Suspicion Questionnaire (LSQ), and analyzes immunoepidemiological aspects and follow-up of individuals living in a presumptively nonendemic area in Brazil.

Methodology/Principal findings

Quasi-experimental study based on LSQ throughout Jardinópolis town by community health agents, theoretical-practical trainings for primary care teams, dermatoneurological examination, anti-PGL-I serology, RLEP-PCR, and spatial epidemiology. A Leprosy Group (LG, n = 64) and Non-Leprosy Group (NLG, n = 415) were established. Overall, 3,241 LSQs were distributed; 1,054 (32.5%) LSQ were positive for signs/symptoms (LSQ+). Among LSQ+ respondents, Q2-Tingling (pricking)? (11.8%); Q4-Spots on the skin? (11.7%); Q7-Pain in the nerves? (11.6%); Q1-Numbness in your hands and/or feet? (10.7%) and Q8-Swelling of hands and feet? (8.5%) were most frequently reported symptoms. We evaluated 479 (14.8%) individuals and diagnosed 64 new cases, a general new case detection rate (NCDR) of 13.4%; 60 were among 300 LSQ+ (NCDR-20%), while 4 were among 179 LSQ negative (NCDR-2.23%). In LG, Q7(65%), Q2(60%), Q1(45%), Q4(40%) and Q8(25%) were most frequent. All 2x2 crossings of these 5 questions showed a relative risk for leprosy ranging from 3 to 5.8 compared with NLG. All patients were multibacillary and presented hypochromatic macules with loss of sensation. LG anti-PGL-I titers were higher than NLG, while 8.9% were positive for RLEP-PCR. The leprosy cases and anti-PGL-I spatial mappings demonstrated the disease spread across the town.

Conclusions/Significance

Implementation actions, primarily LSQ administration focused on neurological symptoms, indicate hidden endemic leprosy in a nonendemic Brazilian state.
Whole-exome sequencing reveals insights into genetic susceptibility to Congenital Zika Syndrome
Authors: Borda Victor , da Silva Francisco Junior Ronaldo , Carvalho Joseane B. , Morais Guilherme L. , Duque Rossi Átila , Pezzuto Paula , Azevedo Girlene S. , Schamber-Reis Bruno L. , Portari Elyzabeth A. , Melo Adriana , Moreira Maria Elisabeth L. , Guida Letícia C. , Cunha Daniela P. , Gomes Leonardo , Vasconcelos Zilton F. M. , Faucz Fabio R. , Tanuri Amilcar , Stratakis Constantine A. , Aguiar Renato S. , Cardoso Cynthia Chester , Vasconcelos Ana Tereza Ribeiro de
Published: June 2021

Congenital Zika Syndrome (CZS) is a critical illness with a wide range of severity caused by Zika virus (ZIKV) infection during pregnancy. Life-threatening neurodevelopmental dysfunctions are among the most common phenotypes observed in affected newborns. Risk factors that contribute to susceptibility and response to ZIKV infection may be related to the virus itself, the environment, and maternal genetic background. Nevertheless, the newborn’s genetic contribution to the critical illness is still not elucidated. Here, we aimed to identify possible genetic variants as well as relevant biological pathways that might be associated with CZS phenotypes. For this purpose, we performed a whole-exome sequencing in 40 children born to women with confirmed exposure to ZIKV during pregnancy. We investigated the occurrence of rare harmful single-nucleotide variants (SNVs) possibly associated with inborn errors in genes ontologically related to CZS phenotypes. Moreover, an exome-wide association analysis was also performed using a case-control design (29 CZS cases and 11 controls), for both common and rare variants. Five out of the 29 CZS patients harbored known pathogenic variants likely to contribute to mild to severe manifestations observed. Approximately, 30% of affected individuals carried at least one pathogenic or likely pathogenic SNV in genes candidates to play a role in CZS. Our common variant association analysis detected a suggestive protective effect of the rs2076469 inDISP3gene (p-value: 1.39 x 10−5). TheIL12RB2gene (p-value: 2.18x10-11) also showed an unusual distribution of nonsynonymous rare SNVs in control samples. Finally, genes harboring harmful variants are involved in processes related to CZS phenotypes such as neurological development and immunity. Therefore, both rare and common variations may be likely to contribute as the underlying genetic cause of CZS susceptibility. The variations and pathways identified in this study may also have implications for the development of therapeutic strategies in the future.
In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function
Authors: Rozario Liza Teresa , Sharker Tanima , Nila Tasnin Akter
Published: June 2021

The mitochondrial tumor suppressor 1 (MTUS1) gene acts as a crucial tumor suppressor by inhibiting growth and proliferation of eukaryotic cells including tumor cell lines. Down regulation of MTUS1 gene has been implicated in a wide range of cancers as well as various human diseases. Alteration through nsSNPs can potentially damage the structure and/or function of the protein. As characterization of functional SNPs in such disease linked genes is a major challenge, it is feasible to analyze putative functional SNPs prior to performing larger population studies. Hence, in this in silico study we differentiated the potentially harmful nsSNPs of the MTUS1 gene from the neutral ones by using various sequence and structure based bioinformatic tools. In a total of 215 nsSNPs, 9 were found to be most likely to exert deleterious effect using 7 prediction tools. From which, 5nsSNPs (S1259L, E960K, P503T, L1084V and L1143Q) were selected as potentially damaging due to their presence in the highly conserved region and ability to decrease protein stability. In fact, 2 nsSNPs (S1259L and E960K) among these 5 were found to be individually associated with two distinctive cancers named Stomach adenocarcinoma and Uterine corpus endometrial carcinoma. As this is the first comprehensive study analyzing the functional nsSNPs of MTUS1, the results of the current study would certainly be helpful in future prospects concerning large population-based studies as well as drug discovery, especially developing individualized medicine.
Measuring transnational social fields through binational link-tracing sampling
Authors: Hâncean Marian-Gabriel , Lubbers Miranda Jessica , Molina José Luis
Published: June 2021

We advance bi-national link-tracing sampling design, an innovative data collection methodology for sampling from so-called “transnational social fields”, i.e. transnational networks embedding migrants, returned migrants and non-migrants. This paper describes our contributions to this methodology and its empirical implementation, and evaluates the features of the resulting networks (sample), with the aim to guide future research. We performed 303 face-to-face structured interviews on sociodemographic variables, migration trajectories and personal networks of people living in a Romanian migration sending community (Dâmbovița) and in a migration receiving Spanish town (Castellón). Inter-connecting the personal networks, we built a multi-layered complex network structure embedding 4,855 nominated people, 5,477 directed ties (nominations) and 2,540 edges. Results indicate that the link-tracing nomination patterns are affected by sex and residence homophily. Our research contributes to the emerging efforts of applying social network analysis to the study of international migration.
Associations of the Big Five and locus of control with problem gambling in a large Australian sample
Authors: von der Heiden Juliane M. , Egloff Boris
Published: June 2021

Gambling may range from being a recreational leisure activity to a behavioral addiction. A rising number of gamblers experience adverse consequences from gambling, termed problem gambling, which may become a challenge for the individual and society. With the present research, we aimed to investigate the correlates of problem gambling. We used a large sample of more than 12,500 individuals (46% male, Mage = 48, SDage = 18) from the Household, Income, and Labour Dynamics in Australia (HILDA) Survey and analyzed sociodemographic and personality variables (Big Five, locus of control) as well as the extent of problem gambling. Findings showed that male sex and a lower level of education were related to problem gambling, but personality traits were predictive of problem gambling over and above sociodemographic variables. Specifically, a low level of emotional stability, an external locus of control, and, to a lesser extent, a low level of conscientiousness and a high level of extraversion were predictive of problem gambling, whereas openness and agreeableness were not. These results remained constant across various robustness analyses. Our findings reveal the importance of including personality traits when explaining gambling behavior.
Hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia: A comparative cross-sectional study
Authors: Arkew Mesay , Yemane Tilahun , Mengistu Yordanos , Gemechu Kabtamu , Tesfaye Girum
Published: June 2021

Background

Diabetes is a global public health problem and associated with metabolic, cellular, and blood disturbances. Hematological changes have been reported in diabetes and play a major role in diabetes-associated complications. However, reports are contradicting and data on hematological parameters of type 2 diabetic patients in the study area are scarce. Therefore, the aim of this study was to assess the hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia from May 01 to June 30, 2020.

Methods

A comparative cross-sectional study was conducted on 268 (134 type 2 diabetic patients and 134 controls) study participants selected by systematic random sampling technique. Socio-demographic, behavioral, and clinical data were collected using a structured questionnaire and checklist. Ethical approval was obtained from Jimma University. All phase of quality assurance was maintained. Hematological parameters and blood glucose levels were determined using UniCel DxH 800 (Beckman Coulter, USA) and Biosystems A25 (Costa Brava, Spain) analyzers, respectively. Independent t-test, Mann–Whitney U-test, correlation, and logistic regression were used during data analysis. P-value <0.05 was considered as statistically significant.

Results

The current study found that total white blood cell count, absolute counts of neutrophil, lymphocyte, eosinophil, and basophil, red blood cell distribution width, platelet count, and mean platelet volume were significantly higher in type 2 diabetic patients as compared to the control group (P<0.05). On the other hand, the mean hemoglobin was significantly lower in type 2 diabetic patients than the control group (P = 0.007). Anemia was found in 17.9% of type 2 diabetic patients. Longer duration of diabetes (AOR = 3.05, 95% CI = 1.12–8.34) and milk consumption (AOR = 4.60, 95% CI = 1.50–14.00) were significantly associated with anemia.

Conclusion

This study showed a statistically significant variation in some hematological parameters of type 2 diabetic patients compared to control group. Anemia among type 2 diabetic patients was found to be a mild public health problem. Therefore, routine screening of hematological parameters should be considered for proper management of type 2 diabetic patients. Close attention should also be given to the duration of diabetes and dietary practice.
Sustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination
Authors: Wong Yik Chun , Liu Wan , Yim Lok Yan , Li Xin , Wang Hui , Yue Ming , Niu Mengyue , Cheng Lin , Ling Lijun , Du Yanhua , Chen Samantha M. Y. , Cheung Ka-Wai , Wang Haibo , Tang Xian , Tang Jiansong , Zhang Haoji , Song Youqiang , Chakrabarti Lisa A. , Chen Zhiwei
Published: June 2021

HIV-1 functional cure requires sustained viral suppression without antiretroviral therapy. While effector-memory CD8+T lymphocytes are essential for viremia control, few vaccines elicit such cellular immunity that could be potently recalled upon viral infection. Here, we investigated a program death-1 (PD1)-based vaccine by fusion of simian immunodeficiency virus capsid antigen to soluble PD1. Homologous vaccinations suppressed setpoint viremia to undetectable levels in vaccinated macaques following a high-dose intravenous challenge by the pathogenic SHIVSF162P3CN. Poly-functional effector-memory CD8+T cells were not only induced after vaccination, but were also recalled upon viral challenge for viremia control as determined by CD8 depletion. Vaccine-induced effector memory CD8+subsets displayed high cytotoxicity-related genes by single-cell analysis. Vaccinees with sustained viremia suppression for over two years responded to boost vaccination without viral rebound. These results demonstrated that PD1-based vaccine-induced effector-memory CD8+T cells were recalled by AIDS virus infection, providing a potential immunotherapy for functional cure.
Life insurance
Authors: Banyár József
Published: June 2021

Why should I read this? Because it is worth to know the logical struchrre of the solutions (and the solutions themselfs) make the long term plamring of the life cycle possible. Because you can know the matematical models behind one of the most bigger financial sector. Because you can recognize the functions and working of the life assurances from Lhe all slakeholders' ( consumers', intermediaries', providers' and regulators') point of view. This book is English version of the second edition of the Hungarian textbook. lt tries to provide a comprehensive pichrre on the aims and working of the life assurances including the traditional mathematical considerations and connections which are making possible the premium and reserve calculation.
Orientação e desenvolvimento pessoal e profissional
Authors: Nickel Daniele Cristine , Seelent João Felipe Capioto
Published: June 2021

O projeto de Orientação e Desenvolvimento Pessoal e Profissional tem como objetivo proporcionar orientações e apoio aos alunos do Setor de Educação Profissional e Tecnológica da Universidade Federal do Paraná e à comunidade em geral, no que diz respeito às questões relacionais, pessoais e profissionais que estejam interferindo no bem-estar biopsicossocial. O projeto visa auxiliar o trabalho desenvolvido pelo Núcleo de Orientação Acadêmica de forma a ampliar o campo de intervenção, uma vez que ele possui um enfoque voltado para as questões educacionais de ensino e aprendizagem. A metodologia adotada envolveu a realização de atividades individuais de orientação e apoio. Os instrumentos e as técnicas utilizadas envolveram a aplicação de testes psicológicos para diagnóstico, entrevistas clínicas, vivências e atividades de sensibilização. As ações desse projeto implicam no bem-estar biopsicossocial dos alunos e da comunidade, de forma a refletir na melhoria dos relacionamentos interpessoais tanto no âmbito pessoal como profissional, redução de faltas excessivas, reprovações, desistências e abandono dos cursos.
A formação continuada para o professor alfabetizador no município de Presidente Kennedy-ES
Authors: Oliveira Sabrina Rosa de , Franco Sebastião Pimentel
Published: June 2021

O texto, fruto do trabalho de conclusão de Mestrado Profissional, apresenta e reflete sobre a experiência de formação continuada dos professores alfabetizadores da cidade de Presidente Kennedy, Espírito Santo. As concepções de autores renomados como Nóvoa (1995) e Freire (2002) contribuíram com suas reflexões sobre a prática pedagógica por meio do aperfeiçoamento dos professores na formação docente, buscando interligar a teoria dos estudos com a prática. A metodologia utilizada foi qualitativa e a análise dos dados coletada através de entrevistas. O professor alfabetizador de Presidente Kennedy precisa estar em constante estudo e formação com o intuito de melhorar o desempenho de suas funções na escola como também na vida profissional, ou seja, ampliar os conhecimentos científicos, cujo alicerce da teoria e reflexão faz parte da mudança e transformação no contexto escolar. Após término da pesquisa foi proposto uma participação ativa dos professores nas formações ofertadas como forma de integração e contribuição na elaboração de um novo modelo de formação construído pelo município, podendo este garantir maior domínio e excelência nos cursos e também no ensino aprendizagem.
Narrativas dos docentes acerca dos desafios e estratégias de enfrentamento das dificuldades no exercício da profissão
Authors: Ribeiro Josivânia Sousa Costa , Pinho Maria José de
Published: June 2021

Este trabalho tem como objetivo narrar as vivências de docentes no exercício da profissão em uma Escola Municipal de Palmas-TO. Destarte, pretendemos relatar dados referentes à profissão, como a escolha, a satisfação e atualização profissional, os desafios e as dificuldades, além de apresentar características resilientes desenvolvidas no âmbito escolar. A metodologia usada foi História Oral Temática. Diante das narrativas das docentes participantes deste trabalho, percebe-se que a escolha da profissão se deu inicialmente por falta de outras opções, mas no decorrer do curso se identificaram e demonstraram que gostam da profissão e se dedicam a ela, apesar de destacarem fatores que podem ser melhorados no contexto escolar, tais como: acreditam que a profissão deveria ser mais valorizada; deve haver envolvimento dos pais na vida escolar dos filhos; a carga horária é excessiva; há indisciplina e desinteresse por parte dos alunos. Nesse caminho, entre os desafios e os enfrentamentos das dificuldades com planejamento e apoio de toda a equipe escolar, a resiliência é primordial para superação das adversidades e a capacidade de se manterem íntegros, proativos fortalecendo o desempenho das atividades profissionais com competência, conhecimento, dedicação, entusiasmo e amor.
O simples é o extraordinário
Authors: Demetrio Islaine Natália
Published: June 2021

Este texto constitui-se de propostas de oficinas e atividades pedagógicas, elaboradas como recurso prático de uma dissertação de Mestrado Profissional em Educação e Docência. O objetivo é apresentar maneiras e possibilidades de aproximação entre sujeitos e atores diretamente envolvidos nos processos educativos escolares de crianças e de adolescentes, bem como propiciar ações do cotidiano escolar que contribuam com a melhoria da aprendizagem, do comportamento de indisciplina e compartilhar os resultados da nossa pesquisa com as escolas e instituições que atendem crianças e adolescentes. Para tanto, elaboramos um caderno com 4 oficinas que foram realizadas, ora no decorrer da pesquisa de mestrado, ora na sala de aula em que atuávamos, um instrumento que pode servir como um material de apoio das atividades pedagógicas. Por meio das oficinas, os alunos da rede estadual e da rede municipal do ensino fundamental começaram a ter relações mais respeitosas, de cooperação e de ajuda mútua. A indisciplina diminuiu, a infrequência teve baixa considerável, eles estão mais comprometidos e motivados a fazerem as atividades, isso se reflete nos resultados das atividades. Pensamos que essas práticas pedagógicas afetaram de modo relevante na trajetória escolar desses alunos, uma vez que também continuamos a acompanhá-los após nossa pesquisa.
Aprendendo a outrar-se
Authors: Nascimento Pedro Pereira do
Published: June 2021

Uruaú é uma comunidade que fica no Município de Beberibe, litoral leste cearense. Uma de suas manifestações culturais é a Cultura dos Papangus, manifestação essa formada a partir de figuras que se mascaram e usam trajes para a construção de performances nas ruas. Este artigo problematiza os métodos de inserção dos brincantes na manifestação a partir do contato com a máscara, o chicote e o traje, e como a relação com esses marcadores dialogam com a realidade socioeconômica da comunidade. O objetivo desse trabalho é interpretar a inserção dos brincantes na manifestação a partir da ideia de educação popular. Para tanto, foi utilizado o método qualitativo, fazendo o uso de observações em campo e conversas com brincantes.
Educação Intercultural e Pós-Colonial na Bolívia
Authors: Filgueiras Isabel Porto , Maldonado Daniel Teixeira
Published: June 2021

O objetivo do estudo foi compreender a relação entre a organização curricular da área de Educação Física e a política de Educação Intercultural boliviana. Trata-se de pesquisa qualitativa de interpretação dos documentos curriculares disponíveis no endereço digital do Ministério da Educação da Bolívia. Foram encontrados, lidos e analisados o Currículo Base do Estado Plurinacional boliviano e os Currículos Regionalizados dos povos indígenas. Observou-se que os objetivos, conteúdos e metodologias propostos para as aulas de Educação Física no Currículo Base não dialogam com os princípios de educação intercultural e descolonizadora defendidos no documento, já que a psicomotricidade, a saúde e pedagogia do esporte predominam como fundamentos da organização curricular. Nos Currículos Regionalizados, elaborados pelas comunidades indígenas autônomas, as práticas corporais figuram como temas curriculares conectados com a tradição cultural e o significado dos exercícios físicos de cada etnia. Portanto, esses currículos rompem com o caráter padronizador da educação e inspiram a construção de práticas educativas que valorizam as diferenças e o multiculturalismo, o que não ocorre com no documento do currículo base. O trabalho evidencia no contexto boliviano incongruências entre o discurso da reforma educacional intercultural e pós-colonial e as propostas curriculares para as aulas de Educação Física.
Educação popular e arte
Authors: Velôso Thelma Maria Grisi , Costa Karolina Mirella Oliveira Pereira , Arruda Leonardo Farias de , Leal Ludwig Félix Machado
Published: June 2021

Neste texto, relata-se uma experiência de extensão universitária na área da Psicologia Social Comunitária, realizada, no meio rural, com crianças e adolescentes de um assentamento constituído pelo Movimento dos Trabalhadores Rurais sem Terra (MST) (Campina Grande/PB). Aliou-se à proposta da Educação Popular a utilização de linguagens artísticas. As oficinas psicopedagógicas realizadas com as crianças e os adolescentes assentados tiveram como objetivo estimular o gosto pela leitura, a reflexão crítica e o protagonismo social. Recorreu-se às diversas linguagens artísticas, entre elas, o método do Teatro do Oprimido proposto por Augusto Boal. Neste trabalho, são relatadas as oficinas realizadas com esse grupo que culminaram com a apresentação de uma encenação teatral para a comunidade. As linguagens artísticas foram um recurso potente para colocar em prática a proposta de acordo com as premissas da Educação Popular.
Documentando as aprendizagens experienciais da docência na/pela relação com estudantes
Authors: Silva Fabrício Oliveira da
Published: June 2021

O relato de experiência emerge de uma prática desenvolvida no ensino de língua portuguesa na Educação Básica. Trata-se de uma experiência com ensino de conjunções desenvolvida em uma escola de ensino regular noturno da cidade de São Paulo. A metodologia ancora-se nas bases epistemológicas da Documentação Narrativa de Experiências Pedagógicas, proposta por Suárez (2007). O dispositivo foi a escrita narrativa, produzida em primeira pessoa, por meio da qual a prática é ao mesmo tempo relatada e refletida, gerando a compreensão da produção de um saber experiencial. O trabalho possibilitou concluir que a aprendizagem experiencial da docência emerge das relações que o professor e os estudantes produzem no tensionamento do ensino que tecem no cotidiano escolar. Documentar a experiência facultou a reflexividade da prática, consagrando-a enquanto um saber experiencial que legitima as aprendizagens da docência que se tecem nas acontecências e nas necessidades de aprendizagem dos estudantes.
Mieczysław Tomaszewski. Muzykolog wolny, niezależny i zaangażowany
Authors: Malecka Teresa
Published: June 2021

The article discusses the culture-creating activities of Mieczysław Tomaszewski (1921–2019) at the Polish Music Publishing House and within the context of Musical Encounters at Baranów Sando- mierski (1976–1981). The text is mainly concerned with Tomasze-wski’s publications relating to twentieth-century Polish composers: Karol Szymanowski, Witold Lutosławski, Krzysztof Penderecki and Henryk Mikołaj Górecki. The reflections of the Polish musicologist are closely entwined with the theoretical conceptions developed by himself: the conception of Wort-Ton, the method of integral interpre-tation of a musical work, the conception of nodal points in the lives of composers, or intertextuality in music. Applying these conceptions allowed him to describe Polish twentieth-century compositions at different levels and in different contexts: beginning with a synthetic periodisation of creative development, up to masterly analyses and interpretations of individual works that take into consideration their intertextual references. The Polish musicologist also paid careful at-tention to composers’ statements testifying to their original views and inner transformations. The problem of freedom was of particular im-portance to him, both in its personal, artistic aspect and in its histor-ical dimension. Tomaszewski as a person reveals himself throughout his activities as someone both free and committed.
Józef Patkowski at the Darmstadt International Summer Courses for New Music
Authors: Nowak Marianne
Published: June 2021

Around 1960, the Darmstadt International Summer Courses for New Music were an important contact point for Polish composers and musicians to the Western avant-garde after years of isolation due to the doctrine of socialist realism imposed in Poland. During this first phase of Polish participation, Józef Patkowski participated twice in the Courses. Mainly based on sources to be found in the archives of the International Music Institute Darmstadt (IMD), this article di-scusses Patkowski’s perception of the Courses as well as his lecture on New Music in Poland which he held in Darmstadt 1962, and gives an insight into the organizational process of artistic contact between Poland and a Western festival.
Uchem krytyka. Idiom kompozytorski Pawła Szymańskiego w ujęciu Andrzeja Chłopeckiego
Authors: Nowicka-Ciecierska Magdalena
Published: June 2021

The article aims to present the compositional idiom of Paweł Szy-mański (b. 1954) as conceived by Andrzej Chłopecki (1950–2012), an outstanding Polish music critic and musicologist. His opinion-forming texts, written in a distinctive language, resonated widely in the Polish and international music community. The article has the character of a review, presenting quotations from Chłopecki’s texts regarded by the author as the most significant, confronted with self-reflections of the composer himself, as well as references to other researchers’ com-ments. The initial part of the article describes Chłopecki’s promotional activities in relation to Szymański’s work. As an active employee of the Polish Radio, Chłopecki was in a position to commission works, prepare programmes on the subject of the composer’s music, as well as organise a monographic festival presenting the majority of his works. The next section of the article recapitulates the first important text by this opinion-forming critic which discusses the works of Szymański, titled W poszukiwaniu utraconego ładu. „Pokolenie” Stalowej Woli [In search of lost order. The Stalowa Wola „generation”]. In it the critic emphasised the role of tonality and the Baroque as the arche-type always present in the composer’s music. The central part of the article discusses the main features of Szymański’s music, the subject of Chłopecki’s later texts; these included heterophony, bidirection-al composing, and the dialectic interplay between structure and its transformations. The last section of the article talks about the charge made by the critic against the composer, that of remaining within the same aesthetics, even though placing his compositions among the most significant and individual phenomena of postmodernist music.
Sfera sacrum w Cronaca del Luogo Luciana Beria
Authors: Nowak Weronika
Published: June 2021

One can point to numerous manifestations of the sphere of sacrum in Luciano Berio’s stage works. It is created in the works of the Italian artist through the use of Christian symbolism, or that associated with the Judeo-Christian tradition, as in the case of Cronaca del Luogo (1999). The sphere of sacrum in Berio’s last stage work is created through such means as intertextual references to the Holy Writ, rabbinic and apocryphal literature and, linked to the creation of specific locations of the action – the space of sacred place, the palace and a Jewish cemetery. Even the title of the work points to the link between the work and the sphere of sacrum, and between the sphere of sacrum and the symbolism of space. This article will present an interpretation of these „imagined worlds” linked to the sphere of sacrum, created by the relationship between words, sounds and images, on the boundary between the space of the „wall” of Salzburg’s Felsen-reitschule, where the work had its premiere, and the imagination of its creators and audiences.
Don Juan Wolfganga Amadeusa Mozarta w reżyserskiej interpretacji Lii Rotbaumówny – próba rekonstrukcji
Authors: Rudnicka Justyna
Published: June 2021

Don Juan by Wolfgang Amadeus Mozart, directed by Lia Rotbaum (Opera Wrocławska, 1969), turned out to be an unorthodox staging supported by deep theoretical reflection. This article attempts to reconstruct this staging, on the basis of what is known as the work’s documentation (director’s copy, photographs, opera programme), reviews, accounts by the singers, as well as the director’s theoretical writings. Don Juan in the interpretation of Lia Rotbaum is an ambivalent figure, who combines contradictory attitudes. He is not a thoroughly negative protagonist; it is the other characters in the opera who, like mirrors, reflect other aspects of his activities. For this reason the director makes the question of responsibility of one person towards another the main theme of the work. Directorial techniques include the use of the revolving stage to give tempo and dynamics to individual scenes; removing and changing the sequence of some musical fragments; operating with studied, rich stage movement, and a highly ordered stage design.
Agency and Agnosis in the Orlando furioso
Authors: Piňos Václav Gabriel
Published: June 2021

This article foregrounds human epistemological disorientation in the Orlando furioso with a view to theological implications which, if not rigorously followed up by Ariosto’s verse (too supple to endure rigor), are nevertheless made possible by its discourse. Beginning with the recurring fantasy-inducing impotence of will (madness) that unite the narrator with the characters, the article examines the Furioso’s own transition from romance to epic mode, aiming to highlight the survival of romance and its subversion of the epistemological exhaustiveness of the epic. By turning to the theological implications of the human epistemological condition that the Orlando furioso repeatedly evokes, it suggests how a functional agnosticism could begin to operate beneath the surface of theic humanist fictions and thought.
Las ninfas de los ríos: Echo(s) zwischen Miguel de Cervantes, Paul Valéry und Jorge Luis Borges als Grundlegung einer Theorie literarischer Resonanz
Authors: Traninger Anita
Published: June 2021

The article takes as its starting point a reading of Jorge Luis Borges’ short storyPierre Menard, autor del Quijote, focusing on the first passage from Cervantes’Quijotethat is quoted verbatim in the text. An invocation of the river nymphs and the nymph Echo („las ninfas de los ríos, la húmida y dolorosa Eco“), it is singled out by the narrator as bearing the voice of Pierre Menard despite having never been attempted by him in his project of writingDon Quijoteagain. I argue that the invocation of Echo does not point to a duplication of the text. Rather, Echo’s early modern acceptation, that of a dialogue partner that not only answers, but answers back and says different things with the same words, encapsulates Menard’s project as such and, beyond that, a theory of literary resonance. Paul Valery’s poems and essays, to which Borges’ story variously alludes, underpin this reading of Echo as the patron saint of a theory of resonance that accounts for the necessary openness of literary texts to deviant interpretations, in particular those that could not have been foreseen or desired by their authors.
Die Zwei Welten des Zauberbergs: Castorps Transzendenz als „inward transcendence“
Authors: Wang Zhu
Published: June 2021

Thomas Mann’s Novel, The Magic Mountain, is characterized by the opposition of two distinct worlds. A comparative study of various novels that share the ‘two worlds’ motif demonstrates to us that the existence of the two worlds plays an essential role in the Bildungsroman. The experience with the new possibilities of life at the sanatorium has given Hans Castorp, the hero of The Magic Mountain, the access to the ideal world. Towards the end of the novel, Castorp has denied the material understanding of death, love and disease that constitutes the world of reality and has thus attained an inward transcendence, which, as Ying-shih Yü argues, characterizes the Chinese intellectual world. Mann’s conception of Bildung as pointing to socialization, which is exemplified by Castorp’s transformation, is apparently opposed to the notion of Bildung as individualization. What is implied in Castorp’s integration into the historical context, the war, is far from a failure of the Bildung, but the noblest form of its triumph.
„Das indianische Kanaan“: Weltliteratur, Exil und epischer Fluss in Alfred Döblins Amazonas
Authors: Weidner Daniel
Published: June 2021

The paper reads Alfred Döblin’s novel Amazonas (1937/1938) in the context of current debates about world literature. It argues that these debates not only refer to a certain group of texts or to a literary system, but concern problems of reading and representation, namely how to read literature beyond the paradigms of national and comparative literature and how to represent a world, especially the modern globalized and secularized world. Döblin’s novel refers to different meanings of ‘world’ that are implied in these questions: It depicts the ‘discovery’ and violent colonization of the ‘New World’ both from the perspective of the indigene people and the Europeans, as well as the ‘Jesuit republic’ as a different project of colonization with an utopian aspect. Written in exile, it also uses the detour via an exotic setting to diagnose a crisis of Europe. Finally it tries to develop a narrative form beyond the novel, using different forms of mythic but also topographic narration which are figured as the materiality of the Amazonas-‘stream.’
An efficient high-frequency method of the EM near-field scattering from an electrically large target
Authors: Qi Conghui , Yi Yang , Yang Wei
Published: June 2021

In this paper, an efficient high-frequency method combining physical optics and shooting and bouncing rays is proposed to calculate the electromagnetic near-field scattering from the electrically large target (such as ship) in the near zone. In order to solve the mono-static and bi-static scattering problems, the local expansion technique based on the facets of target is presented to account for the near-field scattering, which has a singularity-free characteristic. And then the near-field contour-integral representation is introduced by refining the formulations in traditional far-field calculation to reduce the computational complexity. Therefore, this method is more straightforward to deal with the near-field scattering problem. Finally, some analyses on the near-field scattering characteristics and Doppler spectra of a surveillance ship in near zone are investigated by using the proposed method.
Bibliotheken ‚ausgraben‘
Authors: Trenkmann Ulrike
Published: June 2021

(Book) collections are a vital source for both literary studies and provenance research – in spite of the fact that they often exist only in an incomplete and fragmented state. This article examines the transmission of collections from the perspective of source criticism as practiced in archeology. A systematic approach, taking various processes of transformation and reduction into account, already becomes effective before a collection is transferred to a memory institution.
So weit der Faden reicht
Authors: Münkner Jörn
Published: June 2021

Book catalogues can be helpful tools for tracing the history of individual volumes. Nevertheless, how far and how deep in time can we go when we wish to reconstruct the provenance of books by relying on catalogue data? Using material samples, the article demonstrates the spectrum of provenance potential book catalogues hold and can offer.
„Denn das Falsche kann echt werden“
Authors: Seng Joachim
Published: June 2021

: In his autobiographical accounts, Johann Wolfgang Goethe emphasizes the vital role that his father’s collections of books and art had for his own Bildung. In fact, the library of Johann Caspar Goethe (1710–1782) played a vital role in Goethe’s education and early studies while also attesting to his family background and status. However, soon after Johann Caspar’s death, his library was dissolved – and whereas Johann Wolfgang Goethe and other family members integrated some of the books into their own collections, the majority of objects were sold and dispersed. Today, a handwritten catalog commissioned by Goethe’s mother, Catharina Elisabeth Goethe, just before the sale (in 1793/1794), is a critical tool for reconstructing the collection. This article describes the history of Johann Caspar Goethe’s library, its dispersal as well as the efforts to reconstruct the collection. As the retrieval of the original copies from Johann Caspar’s library and the re-establishment of the original collection were impossible, the Freies Deutsches Hochstift has managed to collect equivalent titles and editions in order to restore a library that allows visitors to the Goethe-Haus in Frankfurt to learn about Goethe’s family background, the cultural setting of his upbringing, and early influences on his education.
Provenienz braucht Referenz
Authors: Zedelmaier Helmut
Published: June 2021

Marks that readers leave in books are instructive documents with regard to what readers did with them, how they came in contact with them, and how those books have come down to us. These traces reflect past readers’ attempts to relate to their act of reading while also establishing references to the texts themselves. In retrospect, historians can understand books as mobile vitae, that is, as products created not by an author alone, but also by a network of references that the physical volumes acquired along their transmission history. References of this kind can also help us understand why and how certain books we are interested in today have become objects of our interest.
The Lives of Objects beyond Ownership
Authors: Bilski Emily D.
Published: June 2021

Provenance history sheds light on the relationship between works of art and the social, political, and economic conditions of their biographies. Engaging with the provenance of objects establishes a cultural conversation across time and space with previous owners. For artworks in museums, the public has now entered into that conversation. Museums, as custodians of art and educators of the public, can play a significant role in going beyond the question of ownership to get to the heart of what provenance reveals about the meanings of art: the ways people bring art into their lives, and the ways that objects are loved and studied. This essay delves into these human aspects of provenance, which are too often absent from museum displays, and argues in favor of making this information more visible to the public. Finally, works by contemporary artists Hans Haacke and Maria Eichhorn are discussed as examples of projects that successfully expose complicated object histories and provenance within museum installations.
Comparison of polar ionospheric behavior at Arctic and Antarctic regions for improved satellite-based positioning
Authors: Singh Arun Kumar , Panda Sampad Kumar , Das Rupesh M.
Published: June 2021

In this paper, we investigate the hemispheric symmetric and asymmetric characteristics of ionospheric total electron content (TEC) and its dependency on the interplanetary magnetic field (IMF) in the northern and southern polar ionosphere. The changes in amplitude and phase scintillation are also probed through Global Ionospheric Scintillation and TEC monitoring (GISTM) systems recordings at North pole [Himadri station; Geographic 78°55′ N, 11°56′ E] and South pole [Maitri station; Geographic 70°46′ S 11°44′ E]. Observations show the range of %TEC variability being relatively more over Antarctic region (−40 % to 60 %) than Arctic region (−25 % to 25 %), corroborating the role of the dominant solar photoionization production process. Our analysis confirms that TEC variation at polar latitudes is a function of magnetosphere-ionosphere coupling, depending on interplanetary magnetic field (IMF) orientation and magnitude in the X (

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. Further investigation reveals the intensity of phase scintillation being more pronounced than the amplitude scintillation during the disturbed geomagnetic conditions with excellent correlation with the temporal variation of TEC at both the stations. Corresponding variations in the parameters are studied in terms of particle precipitation, auroral oval expansion, Joule’s heating phenomena, and other ionospheric parameters. The studies are in line with efforts for improving ionospheric delay error and scintillation modeling and satellite-based positioning accuracies in polar latitudes.
Cinnamon oil as a co-chemotherapy agent through inhibition of cell migration and MMP-9 expression on 4T1 cells
Authors: Aliyah Alma Nuril , Lintangsari Ghina , Maran Gergorius Gena , Hermawan Adam , Meiyanto Edy
Published: June 2021

Objectives

The long-term and high-dose use of doxorubicin as chemotherapy for triple-negative breast cancer (TNBC) patients induces epithelial-to-mesenchymal transition (EMT) and stimulates cancer metastasis. Cinnamaldehyde is a major compound of cinnamon oil (CO) suppressing Snail and NFκB activity that are involved in cell migration. This study aims to explore the activity of CO as a co-chemotherapeutic agent on 4T1 breast cancer cells.

Methods

The CO was obtained by water and steam distillation and was characterized phytochemically by gas chromatography-mass spectrometry (GC-MS). Cytotoxic activity of single CO or in combination with doxorubicin was observed by MTT assay. Cell migration and MMP-9 expression were measured by scratch wound healing and gelatin zymography assays. The intracellular reactive oxygen species (ROS) levels were observed by 2′,7′–dichlorofluorescin diacetate (DCFDA) staining flowcytometry.

Results

The phytochemical analysis with GC-MS showed that CO contains 14 compounds with cinnamaldehyde as the major compound. CO exhibited cytotoxicity on 4T1 cells with the IC50 value of 25 μg/mL and its combination with doxorubicin decreased cell viability and inhibited cell migration compared to a single use. Furthermore, the combination of CO and doxorubicin inhibited MMP-9 expression and elevated intracellular ROS levels compared to control.

Conclusions

CO has the potential to be developed as a co-chemotherapy agent through inhibition of cell migration, and intracellular ROS levels elevation.
International Jurisdiction for Investor Claims Based on Prospectus Liability following CJEU 12.9.2018, C-304/17, Löber/Barclays
Authors: Thiede Thomas , Lorscheider Steffen
Published: June 2021

Lately, the value of many products on foreign financial markets has dropped considerably. As a result, affected investors regularly strive to hold the issuers of these products liable before domestic courts. In the following, the relevant European rules of international civil procedural law and the related case law of the Court of Justice of the European Union will be examined. Thereafter, a fresh methodological approach to the questions at hand will be presented.
On Behavioural Asymmetry in Product Liability Law
Authors: Verheyen Thomas
Published: June 2021

This theoretical article identifies the asymmetry between the producer and the consumer as the key to understanding product liability law. In an attempt to resolve the endless scholarly and jurisprudential debates on the proper criterion for defectiveness in European law, it first tracks the ways in which the commonly opposed consumer expectations and risk-utility test each fail to address the typical asymmetries between producers and consumers in a satisfying manner. Building upon the concept of ‘behavioural asymmetry’, it then develops a new criterion for defectiveness under European law: the behavioural risk-utility test. Under a behavioural risk-utility test, the producer is liable if the product is not reasonably safe for average users suffering from cognitive biases and other behavioural shortcomings. This test aptly combines the systemic point of view of risk-utility balancing with an evidence-based conception of asymmetry, and therefore provides a meaningful criterion for adjudicating product liability disputes.
Paul’s Divergence from Jesus’ Prohibition of Divorce in 1 Corinthians 7:10–16
Authors: Chow Chak Him
Published: June 2021

In Paul’s communication to the Corinthian community, we find his reference to Jesus’ absolute prohibition of divorce as he seeks to rebuke some Corinthians’ desire to divorce for the sake of their ascetic pursuit. Following this enlistment of the authority of “the Lord” (1 Cor 7:10), Paul curiously offers his own instruction which contradicts Jesus’. Drawing on insights from the Roman and the Jewish contexts as well as the Foucauldian notion of power, this article argues that Paul is claiming to himself the power and the status of a paterfamilias. His divergence from Jesus’ prohibition of divorce stems from his possible concerns as the paterfamilias of the Corinthian community.