bluuebunny/crossref_metadata_2025 huggingface dataset:
The Results of Scientific Research of Agro-engineering Scientific Organizations on the Development of Digital Systems in Agriculture
Authors:   RAS, Lachuga Yu.F. , Izmaylov A.Yu. ,   VIM, Lobachevsky Ya.P. ,   VIM, Shogenov Yu.Kh. ,   RAS
Published: July 2022

Scientific institutions of agro-engineering profile of the Ministry of Science and Higher Education of the Russian Federation, which are under the scientific and methodological guidance of the Department of Agricultural Sciences of the Russian Academy of Sciences (RAS) in the section of mechanization, electrification and automation, have presented the main scientific and technical achievements and research results for 2021 of in the field of developing new machine technologies, energy-saturated agricultural machinery, mobile energy and robotic technical means, digital systems for the production of the main types of competitive agricultural products, development of efficient energy supply systems using artificial intelligence, renewable energy and modern technical service in the agribusiness.
Analysis of Information Needs in the Field of Agriculture
Authors:   Rosinformagrotekh, Kondratieva O.V. , Fedorov A.D. ,   Rosinformagrotekh, Slinko O.V. ,   Rosinformagrotekh, Voytyuk V.A. ,   Rosinformagrotekh
Published: July 2022

The possibilities of information and analytical support for agricultural producers in modern conditions are considered. The analysis of the number of users of scientific information by federal districts, by the need for information by categories of users and by thematic areas of information materials is given. The role of scientific and technological achievements in the development of the agricultural sector is shown.
PENGEMBANGAN AUGMENTED REALITY MUSEUM CAKRANINGRAT BANGKALAN BERBASIS QR-CODE
Authors: Dellia Prita , Mutiatun Siti , Amil Ahmad Jami'ul
Published: July 2022

Museum menjadi tempat untuk menyimpan cagar budaya yang ada di suatu daerah. Museum merupakan sumber ilmu pengetahuan dan literasi bagi pengunjungnya. Museum menyediakan katalog koleksi-koleksi yang dimiliki dalam bentuk tercetak yang dapat dilihat oleh pengunjung museum. Pengunjung datang dan singgah begitu saja tidak disuguhi data yang komprehensif terkait benda yang dilihat oleh pengunjung. Disisi lain, perlu adanya ketertarikan terhadap museum kaitannya dengan digitalisasi informasi benda yang ada di dalamnya. Pengembangan ini terfokus pada Augmented Reality berbasis QR-Code yang ada di museum yang akan memuat gambar serta deskripsi benda-benda di Museum Cakraningrat Bangkalan. Penelitian ini adalah penelitian pengembangan media pembelajaran berbasis AR untuk memudahkan proses pembelajaran di museum dan pendidikan pengetahuan lokal tentang benda peninggalan yang sarat informasi dan ilmu pengetahuan. Pemahaman isi dari deskripsi benda tersebut memanfaatkan teknologi AR berbasis QR-Code. Desain pengembangan yang digunakan adalah Research and Development Borg and gall dengan lima tahapan penelitian yaitu, identifikasi masalah, pengumpulan informasi, desain produk, validasi desain dan revisi desain. Media AR yang dikembangkan tersebut bisa digunakan pada handphone android atau sejenis nya dengan memanfaatkan QR-Code, sedangkan pengembangannya pada pemanfaatan pengetahuan teknologi dalam benda yang ada dalam museum di Madura. Hasil validasi ahli media didapatkan nilai yaitu  91,7% dan dinyatakan “sangat baik”.
ANALISIS TINGKAT PENERIMAAN APLIKASI BCA MOBILE DI KOTA MALANG MENGGUNAKAN METODE TECHNOLOGY ACCEPTANCE MODEL (TAM)
Authors: Christopher Albert , Tirtana Arif , Aditya Addin
Published: July 2022

Jumlah pengguna aplikasi BCA Mobile dari tahun ke tahun meningkat, namun belum diketahui tingkat penerimaan aplikasi tersebut pada masyarakat. Metode Technology Acceptance Model (TAM) merupakan model yang berfungsi untuk mengukur tingkat penerimaan teknologi yang diukur dari perilaku penggunanya dan telah terbukti keandalannya. Pada penelitian ini menggunakan empat variabel TAM, yaitu perceived usefulness, perceived ease of use, behavioral intention to use dan actual system use. Pada penelitian ini menggunakan 120 responden pengguna aplikasi BCA Mobile yang berada di Kota Malang yang didapat menggunakan rumus Lemeshow. Pada penelitian ini data primer diolah menggunakan aplikasi SPSS, dengan menggunakan teknik analisis jalur. Hasil penelitian ini menunjukkan bahwa H1, H2, H4 dan H5 diterima, sedangkan H3 ditolak. Berdasarkan hasil penelitian tersebut dapat memberikan wawasan bagi pengembang aplikasi untuk terus meningkatkan kualitas aplikasinya.
Viability of Clostridium difficile in mortadella with added essential oils and reduced sodium nitrite content
Authors: Dias Nayane Aparecida Araújo , Pinelli Juliana Junqueira , Silva Monique Suela , Isidoro Silas Rodrigo , Martins Heloísa Helena de Abreu , Gonçalves Michelle Carlota , Ramos Eduardo Mendes , Piccoli Roberta Hilsdorf
Published: July 2022

The effects of additioning essential oil mixtures and reducing the sodium nitrite content (75 ppm) on Clostridium difficile inoculated in mortadellas and on the product’s technological characteristics were evaluated. 15 essential oils were tested preliminarily, but only four were selected. The minimum bactericidal concentrations found were 1.2 % for Ocimum basilicum, 0.3 % for Origanum vulgare and for Thymus vulgaris and 0.15 % for Litsea cubeba. There wasn`t significant difference in viable cell growth between treatments and the control; however, there was an increase in viable cells of approximately 2.5 log10 MPN/g after the fifth day. Combinations of oils didn`t prevent sporulation, however a synergistic effect was observed in vitro. There was a reduction in pH during storage and a greater amount of residual nitrite for the F1 treatment (Origanum vulgare (0.2 %); Thymus vulgaris (0.05 %) and Litsea cubeba (0.025 %), with 10.23 ppm, and reduction of residual nitrite during the storage period from 18.75 ppm on the first day of storage to 5.11 ppm on the last. No significant changes were observed in the technological characteristics of the product with the analyzed treatments.
Morpho-cultural, molecular characterization and identification of the pathogen of the burning of leaf and cashew fruit
Authors: Adriano Benjamim , Romão Dércio , Uaciquete Américo , Mondjana Ana Maria , Bila João , Mulandane Fernando Chanisso
Published: July 2022

The cashew tree (Anacardium occidentale L.) is one of the most important fruit trees cultivated in the semi-arid regions of tropical climate in the world. However, this crop is affected by numerous diseases throughout its production cycle. The burning of the leaf and fruit of cashew is a relatively new disease in Mozambique and is characterized by causing necrotic lesions in fruits and leaves. Thus, the present work was carried out with the objective of isolating and making the morphological and molecular characterization of the fungus responsible for burning the leaf and fruit of the cashew tree and determining its taxonomic identity. The study was based on laboratory tests with the aid of the optical microscope and polymerase chain reaction (PCR). In PDA, cultures of spongy dark coloration were often isolated and distinguished; abundant orange and white and, spongy, typified as Neofusicoccum spp., Colletotrichum spp. and Pestalotiopsis spp., respectively. Molecularly, the results confirmed that at least these genera of fungi are involved in the disease of leaf burning and cashew fruit. No Cryptosporiopsis spp. isolates were isolated. However, it is recommended to evaluate the interactive/synergistic effect of the different isolates obtained from samples with symptoms of leaf burning and cashew fruit in the different stages of host tissue development.
Knowledge of dental professionals and Dental students on bisphosphonates and bisphosphonate-associated osteonecrosis of the jaws
Authors: Paredes Leonardo , Gonçalves Lúcio Souza , Miranda Águida Maria Menezes Aguiar , Santos Netto Juliana de Noronha , Perez Danyel Elias da Cruz , Pires Fábio Ramoa
Published: July 2022

Introduction and objective: the present study assessed the knowledge of dentists and dental students about bisphosphonates and bisphosphonate-associated osteonecrosis of the jaws (BAONJ). Methodology: a survey was applied to dentists and dental students during dental meetings in the city of Rio de Janeiro/RJ, Brazil. Results were descriptively and comparatively analyzed using the SPSS program. Results: the final sample (n=308) was composed mostly by young adults, females (n=233; 76%) and 52% (n=159) were dental students. Most participants (n=185; 60%) were derived from private dental schools. From the total, 79% (n=243) of the participants told they had some information about bisphosphonates, 68% (n=209) recognized BAONJ as a possible side effect of their use, and 84% (n=259) considered important to ask about bisphosphonates use during anamnesis. Participants with more access to information, derived from public dental schools and graduate dentists demonstrated a higher understanding about the indications for bisphosphonates use, their action mechanism, BAONJ as an adverse effect, risk factors associated with the drugs, oral risk factors and oral care measures important to BAONJ risk reduction. Conclusions: there are several knowledge gaps on bisphosphonates and BAONJ and understanding these difficulties is important for the establishment of strategies of diffusion of the information and changing teaching models in dental schools, dental meetings and extension activities.
Cymbopogon sp. from ethnobotany to antimicrobial: an integrative review
Authors: Prado Guilherme Mendes , Prado Júlio Cesar Sousa , Pinheiro Carlos Victor Fontenele , Daza-Cardona Erika Alexandra , Barbosa Francisco César Barroso , Souza Elnatan Bezerra de , Fontenelle Raquel Oliveira dos Santos
Published: July 2022

Considering the broad potential of the genus Cymbopogon, here we present a systematic literature survey on it’s antimicrobial potential. This is a review, articles from the Scielo and PubMed platforms. The articles surveyed were published between 2015 and 2020, with the theme of microbiology, including ethnobotanical studies, literature reviews, in vitro, in vivo, reports of clinical trials. Works outside the selected period, duplicate articles, and those only reporting infections of plants by the microorganism were excluded. 98 studies were selected, 74% found in PubMed and 26% in Scielo. Of this total, 21% were ethnobotanical/ethnopharmacology or literature reviews, most of them reporting the use of infusions of the species C. citratus (DC.) Stapf. Moreover, in 57% of the studies, survey respondents did not report antimicrobial use. In relation to 79% of the experimental studies, it was observed that 77% reported total inhibition of microbial growth, 3% indicated moderate growth inhibition, 4% low growth inhibition and 5% reported no inhibition. Among the microbial species analyzed were Escherichia coli, Pseudomonas aeruginosa, Borrelia burgdorferi, Candida albicans, Salmonella enterica and Saccharomyces cerevisiae. In addition, 5% of the articles reported antiviral activity, 5% parasitic control, 1% preventive action against contamination by mesophilic microorganisms. Although the population is not aware of the antimicrobial activity of Cymbopogon sp., studies have demonstrated its antimicrobial potential, thus the extracts of this genus can be an alternative for use in folk medicine as well as a source of new drugs with antimicrobial action.
Implantação e impactos do protocolo de cirurgia segura adaptado para exame seguro em clínica privada de gastroenterologia
Authors: Solek Sonia Bressiani , Piva Andresa Mohr Lau , Baroni Tamires Fernandes , Anselmo Talyta Bonatto , Soares Greice Sabrina dos Santos , Bragagnollo Bruna Carolina , Glória Bruna Carolina Mateus Pereira , Alves Ana Cleia de Liz , Padilha Cirlei , Borges Fabieli
Published: July 2022

Introdução: A segurança na oferta de cuidado é uma premissa alinhada ao Programa Segurança do Paciente. Dentre as metas instituídas, a cirurgia segura é constante tema de estudo no cenário hospitalar. No entanto, da mesma forma, ambulatórios/clínicas quer seja da inciativa pública ou privada também precisam adaptar os componentes de cirurgia segura para o perfil da sua instituição. Este estudo objetiva escrever a experiência da implantação do protocolo de cirurgia segura adaptado para a realização de exame de gastroenterologia em serviço ambulatorial. Método: estudo descritivo, qualitativo do tipo relato de experiência elaborado na perspectiva da equipe de uma clínica ambulatorial privada especializada em gastroenterologia e diagnóstico das doenças do Sistema Digestório, localizada na cidade de Cascavel, região oeste do Paraná. O protocolo para exames seguros adaptado, foi implantado no ano de 2017 na clínica. Resultados: Foram implementadas três barreiras de segurança que então levaram ao protocolo instituído (protocolo de agendamento, protocolo de anestesia, e, por fim, o protocolo Checklist para exame seguro). Soma-se alguns indicadores apresentados que mostram um panorama desta implantação como, por exemplo, os cancelamentos de exames. A adesão ao protocolo, sobretudo para o protocolo anestésico, foi uma fragilidade inicialmente identificada. Considerações Finais: benefícios foram percebidos, pois possíveis eventos adversos puderam ser barrados por meio da aplicação do protocolo adaptado para o exame seguro. Assim, quaisquer protocolos a serem instituídos demanda constantes reavaliações e estratégias de melhoria contínua. Daí o preponderante papel do enfermeiro no que tange a segurança do paciente.
Políticas públicas voltadas para a fitoterapia com ênfase na odontologia
Authors: Augusco Marco Aurélio Carmona , Sarri Daniela Rezende Abram , Scapin Elisandra
Published: July 2022

Sabe-se que políticas públicas voltadas à fitoterapia estão em fase de expansão no Brasil. Diversas Secretarias Estaduais e Municipais de Saúde implantaram programas de Fitoterapia na atenção primária à saúde, facilitando acesso da população às plantas medicinais e fitoterápicos, suprindo carências medicamentosas e melhorando a qualidade de vida das comunidades menos favorecidas. O descobrimento de plantas com ação na odontologia tem despertado importância na comunidade científica. Encontrar provas científicas do efeito destas plantas é de grande importância para odontologia. Assim, o objetivo desse artigo visa realização de levantamento na literatura das políticas públicas voltadas a fitoterapia com ênfase na odontologia, periódicos da área da saúde; artigos específicos da temática, nos idiomas português, inglês e espanhol, com as palavras-chave: Políticas Públicas, Fitoterapia e Odontologia. Foi realizada uma revisão de literatura nacional e internacional, incluindo trabalhos entre 2012 e 2022, publicações indexadas na SciFinder, BVS, Pubmed, SCIELO, Lilacs, Science Direct e Google acadêmico. Durante a busca encontrou-se inicialmente 52 artigos, contudo estavam disponíveis na integra 38 artigos. Retirou-se artigos que tratam superficialmente da temática, restando 30. Dos estudos analisados submergiram categorias: Políticas públicas na fitoterapia; política nacional de plantas medicinais na odontologia; e o uso de plantas medicinais no Tocantins. Observou-se que, ampliar a importância das políticas públicas na fitoterapia no Brasil promove a saúde pública e aumenta a promoção do uso das plantas medicinais e fitoterápicos. Assim, é indispensável aos profissionais da área da saúde, principalmente cirurgiões-dentistas, conhecer indicações fitoterápicas contra patologias orais, fortalecendo a utilização pelo sistema público de saúde.
Avaliação da qualidade de vida em portadores de Diabetes Mellitus e suas complicações
Authors: Reis Letícia Oliveira , Silva Ana Karoline dos Santos , Brito Maria dos Remédios Mendes de
Published: July 2022

Devido à alta prevalência de diabetes e suas complicações, a avaliação da qualidade de vida dos pacientes é fundamental. Dessa forma o objetivo desta pesquisa foi revisar na literatura disponível de forma integrativa para esclarecer os aspectos relacionados a qualidade de vida de pacientes acometidos por Diabetes Mellitus. Trata-se de um estudo de revisão integrativa de literatura com abordagem qualitativa e a coleta de dados foi realizada por meio da busca ativa de informações nas bases de dados eletrônicas: Scientific Eletronic Library Oline (ScieLO), PubMed e Science Direct. As complicações do Diabetes mellitus podem ser responsáveis pela maior parte da morbimortalidade associada à doença, portanto, avaliar a qualidade de vida dos pacientes em intervalos regulares é uma necessidade para o Diabetes mellitus como doença crônica e essa avaliação, como uma ferramenta poderosa, é fundamental na previsão do estado dos pacientes para o manejo da doença e cuidados de saúde de longo prazo. Na presente revisão foi possível verificar que a qualidade de vida dos pacientes com diabetes é afetada por inúmeros fatores, como sexo, ocupação, histórico de doença e presença de complicações.
Forage productivity and morphogenesis of Axonopus aureus under defoliation levels
Authors: Costa Newton de Lucena , Magalhães João Avelar , Rodrigues Braz Henrique Nunes , Santos Francisco José de Seixas
Published: July 2022

The effect of defoliation levels (5, 10, 15, 20, 25 and 30 cm above soil level) on dry matter (DM) yield and morphogenetic and structural characteristics of Axonopus aureus was evaluated under field conditions in Roraima´s savannas. The effects of defoliation levels on the DM yields, absolute growth rate, number of leaves/plant, medium blade length, leaf area, leaf appearance and elongation rates were quadratics and maximum values recorded with cutting at 19.2; 17.5; 20.7; 27.2; 24.3; 20.5 e 25.9 cm above soil level. The population tiller density was directly proportional to the level of defoliation, while the opposite occurred for to leaf senescence rate. Apical meristem removing percentage was higher with increasing defoliation level. Aftermath regrowth showed close negative correlation with defoliation level. Pastures of A. aureus managed under residues between 15 and 25 cm above the ground provide greater productivity and efficiency of forage use, greater tissue renewal and a more favorable canopy structure for grazing.
Pelatihan Pemanfaatan Bahan Pisang Sebagai Makanan Pendamping Air Susu Ibu Dalam Pencegahan Stunting Di Desa Lamu
Authors: Junus Nirwan , Mamu Karlin Z
Published: July 2022

Kegiatan Program Pengabdian Kolaboratif ini berupa Penyuluhan dan diskusi dengan masyarakat Desa Lamu Kecamatan Batudaa Pantai tentang proses pengolahan pangan lokal menjadi makanan bergizi untuk anak usia dini, Penyampaian materi serta praktek langsung dengan masyarakat, Pelatihan Pemanfaatan sumber daya pangan lokal dengan menggunakan bahan pisang lokal. Tujuan khusus dalam program pengabdian ini diharapkan mampu menjadi masukan kepada pemerintah agar lebih memperhatikan permasalahan stunting yang harus dicegah sejak dini. Salah satu hasil dari program pelatihan pemanfaatan bahan pangan lokal ini yakni berbentuk produk Makanan Pendamping ASI berbahan pisang. Pemilihan bahan pisang sendiri dikarenakan rasanya yang manis dan lembut, bayi senang memakannya, selain teksturnya yang mudah dikonsumsi saat pemberian MP-ASI, buah pisang juga kaya akan nutrisi dan memiliki beragam manfaat yang dapat membantu perkembangan bayi. Tawaran ini  juga diharapkan dapat membantu pemerintah dalam mencegah permasalahan stunting. Adapun tujuan lain pada program pengabdian kolaboratif ini yakni upaya untuk mewujudkan ketahanan pangan, yang kemudian diharapkan mampu menunjang perkembangan ekonomi kreatif oleh ibu-ibu rumah tangga dalam memanfaatkan sumber daya pangan lokal.
DEWITA Sebagai Program Unggulan Pemberdayaan Masyarakat Biluhu Timur
Authors: Badu Lisnawaty Wadju
Published: July 2022

Program dalam kegiatan ini berupa sosialisasi pengembangan Wisata Bahari di Desa Biluhu Timur dengan memberikan edukasi mengenai promosi wisata bahari Biluhu Timur. Sehingga, masyarakat dapat mempromosikan wisata yang tersedia di desa Biluhu Timur agar nantinya bisa menarik banyak wisatawan datang berkunjung ke desa Bluhu Timur. Tujuannya adalah untuk meningkatkan peran warga dalam mengembangkan desa pariwisata, termasuk meningkatkan perekonomian mandiri. Maka untuk mencapai tujuan dari program pengembangan Wisata Bahari desa Biluhu Timur, Tim KKN juga menyelenggarakan beberapa program tambahan untuk mendukung pembangungan desa wisata di Biluhu Timur meliputi kegiatan penataan kebun PKK dan pengecatan lorong pelangi yang bertujuan untuk memberikan warna disepanjang jalan mulai dari gerbang sampai kantor desa sehingga akan terlihat lebih menarik dan diharapkan bisa menarik minat wisatawan. Selanjutnya, pembersihan pesisir pantai di area wisata Itoduti Beach, Global Dive Center, dan Horison Dive Camp, sehingga wisatawan akan merasa lebih nyaman ketika mengunjugi wisata yang ada di Biluhu Timur. Adapun, kegiatan pembenahan spot foto di area wisata Itoduti Beach yang bertujuan memperindah area wisata dan menarik minat wisatawan yang dilakukan melalui pembuatan spot foto, pagar, dan pengecatan. Tujuan dari Dewita sebagai program unggulan pemberdayaan masyarakat biluhu timur yakni memberikan manfaat khususnya terhadap aparat dan seluruh masyarakat desa dalam pembangunan, pengembangan dan penataan desa yang mengarah pada kemajuan sektor pariwisata di Biluhu Timur menjadi desa Wisata Bahari.
Cooperation of Ukraine with international financial partners in martial law
Authors:   SESE “The Academy of Financial Management”, KLYMENKO Kateryna , SAVOSTIANENKO Maksym ,   SESE “The Academy of Financial Management”
Published: July 2022

Introduction. Strategic directions of Ukraine’s development require improvement of the process of formation and implementation of the state’s foreign policy, the delineation of priority vectors of cooperation with international ?nancial partners, including IFIs. Problem Statement. The need to take into account the challenges and threats that arise in the current realities of the application of programs to support the formation and development of a platform for cooperation with international ?nancial institutions (IFIs) / partners in the martial law in Ukraine. Purpose. To study the state of attraction and use of loans (credits) of IFIs and international partners during the martial law in Ukraine, in particular to identify key areas, objectives, expected results of attracting international ?nancial assistance and prospects for further cooperation in accordance with state policy documents. Methods. General and special methods are used: analysis, synthesis, grouping, description, comparison, theoretical generalization and abstract-logical. Results. The programs of emergency ?nancial support of Ukraine by international ?nancial institutions and other partners in the conditions of martial law are analyzed. Preliminary estimates of the economic losses that Ukraine has already su?ered as a result of the Russian military invasion are analyzed. An analysis of projects and promising areas of development and implementation of postwar reconstruction programs in the framework of international ?nancial cooperation. Conclusions. The need for appropriate legislative regulation to ensure effective, targeted and controlled use of emergency financial resources of international partners involved under new and improved mechanisms is substantiated. It is extremely important to improve or develop regulations in the ?eld of ensuring e?ective international ?nancial cooperation of Ukraine: adoption of a new medium-term Strategy of cooperation with IFIs; formation of scienti?c and methodological approach to assessing ?nancial security of Ukraine in the context of attracting credit and ?nancial resources of IFIs; adoption of a new Partnership Strategy of Ukraine and the World Bank for 2022-2026.
Жіночі тестаменти родин козацької старшини XVII-XVIII ст.
Authors: Kryvosheia Iryna
Published: July 2022

У статті вивчаються тестаменти представниць родин козацької старшини Гетьманщини XVII-XVIII ст. Укладення заповіту було проявом підготовки до «доброї» смерті. Козацька старшина, успадкувавши традиції попередньої доби, намагалася їх дотримуватися, особливо в ритуалах, пов’язаних зі смертю. Метою дослідження є аналіз усіх відомих на сьогодні тестаментів жінок із козацько-старшинських родин XVII-XVIIІ ст. У статті тестаменти виступають як джерело знань про майнові права жінок, їх стосунки з родиною/родичами, про вдачу жінок, уявлення про жіночі чесноти, про освіту чи неосвіченість авторок. Предметом дослідження стали реалії життя жінок зі старшинських родин крізь призму їхніх тестаментів. Значна увага приділяється тестаменту як історичному джерелу.

Наукова новизна: вперше зібрано та проаналізовано нині доступні 62 тестаменти представниць козацько-старшинських родин.

Висновки. Жіночі тестаменти XVII-XVIII ст. містять багато інформації про матеріальну культуру епохи. Здебільшого, жіночі тестаменти включають переліки одягу, коштовностей і хатнього начиння, що розподіляється між нащадками. Заповіти містять багато цінних деталей, що дозволяють уточнити та розширити розписи козацько-старшинських родин Гетьманщини. Особливо ефективними стають тестаменти, якщо їх використовувати у комплексі з іншими джерелами тієї доби. Для тестаментів тієї доби характерний виважений тон. Відчувається спокійне сприйняття конечності власного життя. Усі заповіти містять вказівки надати гроші чи інше майно на спомин душі в храми та монастирі. Однак лише у 12 заповітах є чітка вказівка про місце поховання. Це або церкви в місцях проживання, або великі монастирі, для яких здійснено пожертви. Більшість жінок залишали це питання на розсуд рідних. У переважній більшості випадків тестаменти укладені вдовами поважного віку і вони розпоряджаються як власним майном, так і спадком чоловіка. Із 62 заповітів у 10 знаходимо звістку про два шлюби, в одному – 3. Більшість жінок, навіть із вищих верств населення, у XVIII ст. були неграмотні. Це засвідчує вибірка тестаментів. Із 51 у 20 документах є чітка вказівка на неграмотність тестаторки. І це жінки з найвідоміших родин Гетьманщини. У жодному з жіночих тестаментів не згадано книги. Особливість жіночих тестаментів проявляється у виразному домінуванні переживань про рідних, попри близькість власної смерті.
Очаків і його околиці на картах і планах експедицій А.Ж. де Лафітта-Клаве 1784 та 1787 років
Authors: Sapozhnykov Іgor
Published: July 2022

Мета статті полягає у публікації й аналізі низки картографічних матеріалів, створених французькими топографами, гідрографами та військовими інженерами в Очакові та його околицях під час двох експедицій майора (підполковника) А.Ж. де Лафітта-Клаве (23.02.1740–01.1794). Йдеться про морську подорож уздовж берегів Чорного моря, під час якої 5-27 червня 1784 р. був досліджений Очаків і масштабні роботи з реконструкції укріплень цього міста, що відбувалися у травні-листопаді 1787 р.

Наукова новизна полягає у введені до наукового обігу карт і планів Очакова та навколишніх місць, зроблених під час вищезазначених експедицій, які залишались майже невідомими понад два століття.

Присвячені цим експедиціям картографічні матеріалі, які зберігаються в архівах Французької Республіки та Російської Федерації, досі були опубліковані вкрай фрагментарно, хоча інші письмові джерела названих місій (рапорти, травелоги та листування) відомі набагато краще. Але останнім часом на інтернет-сайті «Gallica» Національної бібліотеки Франції та її партнерів виставлено багато карт і планів Очакова та його округи кінця XIX ст., які складають основу даної статті. Також стаття супроводжується окремим додатком-каталогом картографічних матеріалів.

Висновки. У ході проведеного дослідження вдалося розширити історичні та археологічні знання стосовно очаківського регіону, оскільки у розглянутих картах наявний значний обсяг унікальної інформації щодо географії та гідрографії, ойко- і топоніміки цього краю, вказано розташування деяких археологічних пам’яток (низки курганів і давнього городища), є планіграфія османських фортифікаційних споруд і міської забудови, проекти реконструкції укріплень і будівельних робіт, фактично виконаних під наглядом А.Ж. де Лафітта-Клаве.
Бездоглядність і злочинність неповнолітніх у Житомирській області в середині 1960-х – на початку 1970-х рр. та заходи їхньої профілактики
Authors: Vlasyuk Igor
Published: July 2022

Метою статті є аналіз стану дитячої бездоглядності та підліткової злочинності у названому регіоні в середині 1960-х – на початку 1970-х рр. та заходів, спрямованих на подолання цих проблем серед неповнолітніх.

Наукова новизна статті полягає в тому, що автор намагається створити, відсутнє на сьогодні, комплексне дослідження стану та профілактики дитячої бездоглядності і підліткової злочинності у Житомирській області зазначеного періоду.

Висновки. Серйозною проблемою в УРСР, та зокрема в Житомирській області, у другій половині 1960-х – на початку 1970-х рр. було зростання бездоглядності та злочинності серед неповнолітніх. Серед цих злочинів переважали крадіжки особистого та державного майна, хуліганство. Відповідні органи влади вживали заходів до правопорушників, а також до запобігання скоєння їх неповнолітніми. Однак перевірки показали недостатній контроль та інші серйозні недоліки з боку відповідних органів, шкіл у роботі з неповнолітніми правопорушниками. В умовах влади правлячої партії та її ідеології чітко розставлялися акценти й у питаннях боротьби з підлітковою злочинністю, проводилося атеїстичне виховання молоді.

Серед профілактичних заходів важливе значення мала правильна організація виховної роботи серед дітей і підлітків, яка потребувала уваги з боку школи та батьків, підприємств, на яких вони працювали.

Одним з важливих напрямів роботи державних органів було запобігання нещасних випадків серед дітей. Проблема була особливо актуальною щодо бездоглядних дітей, учнів, які не відвідували або часто пропускали заняття в школі.

Подальшого дослідження потребує проблема дитячої бездоглядності та злочинності неповнолітніх у Житомирській області у 1970-х – 1980-х рр.
Strengthening the Role of Women in Preventive against Covid-19 Efforts in Kampung Tenun, Topa Village, Baubau
Authors: Samrida Wa Ode Nesya Jeni , Minarti Minarti , Syarif Syastriani Isna Putri
Published: July 2022

Introduction: The spread of the COVID-19 virus is increasing, especially in Kampung Tenun, Topa Village, Baubau. Women take a big role in ensuring the health of the family. All information that is a source of improving family health becomes part of the role of women as wives, mothers and children. The purpose of this activity is to ensure that women have the correct information about COVID-19 so that their families are well educated and healthy during the pandemic. Methods: The implementation of the activity uses the community participation method with indicators of community participation in activities, namely first through counseling about covid-19 and how to prevent it, a dissertation on pre-posttest evaluation, hand washing practices and fitness exercise activities for 60 minutes with an instructor. participants totaled 30 people. The results of the counseling activity showed that after receiving counseling related to Covid-19 prevention, there was an increase in the knowledge of the women of the Topa Village Weaving Village, being able to practice good and correct hand washing and enthusiastically participating in counseling activities. fitness training hopes to become a resident's routine. We hope that activities involving women must be sustainable because women's role is very large for health starting at home (family).
A Copula-Based Simulation of Wave-Induced Pore Water Pressure Gradient and Local Acceleration Within Surf Zone for Natural and Laboratory Barred Beach Profiles
Authors: Tabasi Mohammad , Suzuki Takayuki , Cox Daniel T.
Published: July 2022

Wave-induced pressure gradients and local accelerations are important interconnected physical mechanisms involving several hydrodynamic and morphodynamic coastal phenomena. Therefore, to provide a reliable and realistic hydrodynamic and morphodynamic simulation, the dependencies among different parameters, such as water level, pressure gradient, local acceleration, and sediment concentration, should be considered. Herein, a copula-based simulation is presented for modeling multivariate parameters and maintaining their statistical characteristics within the surf zone. Archimedean and elliptical copula families are applied to investigate the dependency construction between the parameters in two case studies: one from a field site on the east coast of Japan, and another from a large-scale laboratory barred beach profile. The dependency between variables is evaluated using Kendall’s τ correlation coefficient. The water level, pressure gradient, and local acceleration are shown to be significantly correlated. The correlation coefficients between the variables for the natural beach are lower than the laboratory data. The marginal probabilistic distribution functions and their joint probabilities are estimated to simulate the variables using a copula approach. The performance of the simulations is evaluated via the goodness-of-fit test. The analysis shows that the laboratory data are comparable to the field measurements, implying that the laboratory simulation results can be applied universally to model multivariable joint distributions with similar hydrodynamic conditions.
Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery
Authors: Teng Xin-Qi , Qu Jian , Li Guo-Hua , Zhuang Hai-Hui , Qu Qiang
Published: July 2022

Gliomas are central nervous system tumors originating from glial cells, whose incidence and mortality rise in coming years. The current treatment of gliomas is surgery combined with chemotherapy or radiotherapy. However, developing therapeutic resistance is one of the significant challenges. Recent research suggested that small interfering RNA (siRNA) has excellent potential as a therapeutic to silence genes that are significantly involved in the manipulation of gliomas’ malignant phenotypes, including proliferation, invasion, metastasis, therapy resistance, and immune escape. However, it is challenging to deliver the naked siRNA to the action site in the cells of target tissues. Therefore, it is urgent to develop delivery strategies to transport siRNA to achieve the optimal silencing effect of the target gene. However, there is no systematic discussion about siRNAs’ clinical potential and delivery strategies in gliomas. This review mainly discusses siRNAs’ delivery strategies, especially nanotechnology-based delivery systems, as a potential glioma therapy. Moreover, we envisage the future orientation and challenges in translating these findings into clinical applications.
Axons in the Chick Embryo Follow Soft Pathways Through Developing Somite Segments
Authors: Schaeffer Julia , Weber Isabell P. , Thompson Amelia J. , Keynes Roger J. , Franze Kristian
Published: July 2022

During patterning of the peripheral nervous system, motor axons grow sequentially out of the neural tube in a segmented fashion to ensure functional integration of the motor roots between the surrounding cartilage and bones of the developing vertebrae. This segmented outgrowth is regulated by the intrinsic properties of each segment (somite) adjacent to the neural tube, and in particular by chemical repulsive guidance cues expressed in the posterior half. Yet, knockout models for such repulsive cues still display initial segmentation of outgrowing motor axons, suggesting the existence of additional, yet unknown regulatory mechanisms of axon growth segmentation. As neuronal growth is not only regulated by chemical but also by mechanical signals, we here characterized the mechanical environment of outgrowing motor axons. Using atomic force microscopy-based indentation measurements on chick embryo somite strips, we identified stiffness gradients in each segment, which precedes motor axon growth. Axon growth was restricted to the anterior, softer tissue, which showed lower cell body densities than the repulsive stiffer posterior parts at later stages. As tissue stiffness is known to regulate axon growth during development, our results suggest that motor axons also respond to periodic stiffness gradients imposed by the intrinsic mechanical properties of somites.
Stromal and Immune Cell Dynamics in Tumor Associated Tertiary Lymphoid Structures and Anti-Tumor Immune Responses
Authors: Rossi Alessandra , Belmonte Beatrice , Carnevale Silvia , Liotti Antonietta , De Rosa Veronica , Jaillon Sebastien , Piconese Silvia , Tripodo Claudio
Published: July 2022

Tertiary lymphoid structures (TLS) are ectopic lymphoid organs that have been observed in chronic inflammatory conditions including cancer, where they are thought to exert a positive effect on prognosis. Both immune and non-immune cells participate in the genesis of TLS by establishing complex cross-talks requiring both soluble factors and cell-to-cell contact. Several immune cell types, including T follicular helper cells (Tfh), regulatory T cells (Tregs), and myeloid cells, may accumulate in TLS, possibly promoting or inhibiting their development. In this manuscript, we propose to review the available evidence regarding specific aspects of the TLS formation in solid cancers, including 1) the role of stromal cell composition and architecture in the recruitment of specific immune subpopulations and the formation of immune cell aggregates; 2) the contribution of the myeloid compartment (macrophages and neutrophils) to the development of antibody responses and the TLS formation; 3) the immunological and metabolic mechanisms dictating recruitment, expansion and plasticity of Tregs into T follicular regulatory cells, which are potentially sensitive to immunotherapeutic strategies directed to costimulatory receptors or checkpoint molecules.
Fluorescence Imaging of Extracellular Potassium Ion Using Potassium Sensing Oligonucleotide
Authors: Sato Shinobu , Ohzawa Shinsuke , Sota Kojiro , Sakamoto Naoto , Udo Ayano , Sueda Shinji , Matsuda Tomoki , Nagai Takeharu , Takenaka Shigeori
Published: July 2022

Potassium-sensing oligonucleotide, PSO, a conjugate of a quadruplex structure-forming oligonucleotide with a peptide incorporating a Förster Resonance Energy Transfer (FRET) chromophore pair, has been developed for fluorescent detection of potassium ion (K+) in aqueous medium. PSO 1 could be introduced into cells for real-time imaging of cytoplasmic K+ concentrations. To perform fluorescent imaging of K+ on the cell surface, we synthesized twelve PSO derivatives with different types of peptide types and lengths, and oligonucleotide sequences including thrombin-binding aptamer (TBA) sequences with FAM and TAMRA as a FRET chromophore pair, and evaluated their performance. 1 was shown to respond selectively to K+, not to most ions present in vivo, and to show reciprocal fluorescence changes in response to K+ concentration. For the peptide chains and oligonucleotide sequences examined in this study, the PSO derivatives had Kd values for K+ in the range of 5–30 mM. All PSO derivatives showed high K+ selectivity even in the presence of excess Na+. The PSO derivatives were successfully localized to the cell surface by biotinylated concanavalin A (ConA) or sulfo-NHS-biotin via streptavidin (StAv). Fluorescence imaging of extracellular K+ upon addition of apoptosis inducers was successfully achieved by 1 localized to the cell surface.
Aerosol Jet Printing of Hybrid Ti3C2Tx/C Nanospheres for Planar Micro-supercapacitors
Authors: Wu Yu , Lin Aiping , Zhang Jidi , Zhao Danjiao , Fan Lanlan , Lu Cheng , Wang Shufen , Cao Lei , Gu Feng
Published: July 2022

When utilized in energy devices, the restacking tendency of MXene Ti3C2Tx inhibits its electrochemical performance. Using aerosol jet printing (AJP) technology, hybrid Ti3C2Tx/C nanospheres are synthesized with C nanoparticle-bonded MXene nanosheets, and the restacking of MXene nanosheets is blocked efficiently. The formation mechanism for hybrid Ti3C2Tx/C nanospheres has been hypothesized, and the Ti3C2Tx/C is anticipated to assemble and shape along the droplet surface in tandem with the Marangoni flow within the droplet. The planar microsupercapacitor devices generated from these hybrid spherical nanostructures with increased interlayer spacing exhibit exceptional areal capacitance performance. This concept offers a straightforward and effective method for constructing 3D-structured MXene with suppressed self-stacking for diverse high-performance micro energy storage devices.
Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin
Authors: Ke Li-Na , Kong Ling-Qi , Xu Huan-Huan , Chen Qin-Hua , Dong Yun , Li Bin , Zeng Xiao-Hua , Wang Hong-Mei
Published: July 2022

Gynecological malignancy seriously threatens the physical and mental health of women. Shikonin is a naphthoquinone compound with a variety of biological activities. Studies have shown that shikonin can inhibit cell proliferation, promote cell apoptosis and induce cell necrosis. And in recent years, shikonin are also being increasingly used for the study of gynecological malignant diseases. Therefore, we reviewed the mechanism of action and structure optimization of shikonin in gynecological malignant tumors, in order to provide some reference for further research and development of related drug.
Cationic Interstitials: An Overlooked Ionic Defect in Memristors
Authors: Xu Zhemi , Guan Peiyuan , Ji Tianhao , Hu Yihong , Li Zhiwei , Wang Wenqing , Xu Nuo
Published: July 2022

Metal oxide-based memristors are promising candidates for breaking through the limitations in data storage density and transmission efficiency in traditional von Neumann systems, owing to their great potential in multi-state data storage and achievement of the in-memory neuromorphic computing paradigm. Currently, the resistive switching behavior of those is mainly ascribed to the formation and rupture of conductive filaments or paths formed by the migration of cations from electrodes or oxygen vacancies in oxides. However, due to the relatively low stability and endurance of the cations from electrodes, and the high mobility and weak immunity of oxygen vacancies, intermediate resistance states can be hardly retained for multilevel or synaptic resistive switching. Herein, we reviewed the memristors based on cationic interstitials which have been overlooked in achieving digital or analog resistive switching processes. Both theoretical calculations and experimental works have been surveyed, which may provide reference and inspiration for the rational design of multifunctional memristors, and will promote the increments in the memristor fabrications.
Design, Synthesis, and Biological Evaluation of N-Acyl-Homoserine Lactone Analogs of Quorum Sensing in Pseudomonas aeruginosa
Authors: Wei Zhenyu , Li Ting , Gu Yan , Zhang Qian , Wang Enhui , Li Wenbo , Wang Xin , Li Yang , Li Hongyu
Published: July 2022

Quorum sensing plays a necessary role in the production of virulence factors and the formation of biofilm on Pseudomonas aeruginosa. Thus, the development of inhibition of quorum sensing is one of the most promising methods to control bacterial infection and antibiotic resistance. In this work, nine novel AHL analogs were designed, synthesized, and evaluated as potential quorum sensing inhibitors. The results depicted that structural modifications have significant effects on quorum sensing inhibition activity of AHL molecules. Without inhibiting the growth of P. aeruginosa, 2-(4-bromophenyl)-N-(2-oxotetrapyridinefuran-3-yl) butanamide (compound no.10) showed the excellent performance in inhibiting biofilm formation and virulence factor production among all the compounds through robustly suppressing the expression of QS related genes. In a molecular docking study, compound no.10 exhibited a higher affinity toward LasR than other AHL analogs. In addition, compound no.10 also exhibits the best inhibition effect on virulence production in the Caenorhabditis elegans infection model.
Induction of Autophagy by Ursolic Acid Promotes the Elimination of Trypanosoma cruzi Amastigotes From Macrophages and Cardiac Cells
Authors: Vanrell María Cristina , Martinez Santiago José , Muñoz Lucila Ibel , Salassa Betiana Nebaí , Gambarte Tudela Julián , Romano Patricia Silvia
Published: July 2022

Chagas disease, caused by the parasite Trypanosoma cruzi, is an infectious illness endemic to Latin America and still lacks an effective treatment for the chronic stage. In a previous study in our laboratory, we established the protective role of host autophagy in vivo during T. cruzi infection in mice and proposed this process as one of the mechanisms involved in the innate immune response against this parasite. In the search for an autophagy inducer that increases the anti-T. cruzi response in the host, we found ursolic acid (UA), a natural pentacyclic triterpene with many biological actions including autophagy induction. The aim of this work was to study the effect of UA on T. cruzi infection in vitro in the late infection stage, when the nests of intracellular parasites are forming, in both macrophages and cardiac cells. To test this effect, the cells were infected with T. cruzi for 24 h and then treated with UA (5–10 µM). The data showed that UA significantly decreased the number of amastigotes found in infected cells in comparison with non-treated cells. UA also induced the autophagy response in both macrophages and cardiac cells under the studied conditions, and the inhibition of this pathway during UA treatment restored the level of infection. Interestingly, LC3 protein, the main marker of autophagy, was recruited around amastigotes and the acidic probe LysoTracker localized with them, two key features of xenophagy. A direct cytotoxic effect of UA was also found on trypomastigotes of T. cruzi, whereas epimastigotes and amastigotes displayed more resistance to this drug at the studied concentrations. Taken together, these data showed that this natural compound reduces T. cruzi infection in the later stages by promoting parasite damage through the induction of autophagy. This action, in addition to the effect of this compound on trypomastigotes, points to UA as an interesting lead for Chagas disease treatment in the future.
Genital Microbiota of Women From Six Ethnic Groups With and Without Human Papillomavirus Infection in Shangri-La, China
Authors: Liu Chen-Jian , Xiao Wen-Yu , Fang Jun-Feng , Dong Yong-Hong , Ye Ke-Fan , He Meng-Ping , Wang Yan-Song , Li Xiao , Zhao Zhi-Min , Yuan Tao , Zhao Ting , He Chun-Yan , Zhang Shu-Ming , Yang En , Wu Xiao-Mei , Li Xiao-Ran
Published: July 2022

Background

A diversity of microorganisms is associated with human health and exists in a state of dynamic equilibrium. This diversity has direct implications for the assessment of susceptibility to infectious diseases, especially human papillomavirus (HPV) infection.

Methods

Here, we investigated the relationships between HPV infection and vaginal, cervical, and gut microbiota composition and assessed the levels of genital immune mediators. We selected a multiethnic area in Yunnan Province, China, to collect samples from healthy women of childbearing age. A total of 82 healthy women of childbearing age were included in this study. Vaginal, cervical, and rectal swabs were collected to analyze the microbial community, and cytokines were analyzed in some samples.

Findings

Different proportions and types of HPV infection were detected in cervical (44%), vaginal (18%), and rectal (18%) swabs. HPV detected in cervical swabs was generally a high-risk type, while low-risk HPV types were primarily detected in vaginal and rectal swabs. There were some differences in this proportion as well as in the microbial community composition among different ethnic groups. Rectal samples exhibited the highest diversity index, while vaginal samples displayed the lowest diversity index. Lactobacillus dominated most of the vaginal samples, was decreased in HPV-positive samples, and differed among different ethnic groups. However, the sequence proportion of Lactobacillus in the cervix exhibited the opposite trend in those affected by HPV infection. The dynamic balance between the potential pathogens Gardnerella and Lactobacillus determines the health of the female genital system.

Interpretation

This study constitutes the first step toward personalized medicine for women’s reproductive health, wherein differences between the genital microbiomes of individuals would be considered in risk assessment and for subsequent disease diagnosis and treatment.