bluuebunny/crossref_metadata_2025 huggingface dataset:
IgE e IgG específicas para antigénios do Aspergillus fumigatus no diagnóstico da aspergilose broncopulmonar alérgica
Authors:   Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina, Universidade do Porto, Portugal, Beltrão Marília , Ferreira Ana ,   Serviço de Imunoalergologia, Centro Hospitalar Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal, Pereira Ana ,   Laboratório de Imunologia, Serviço de Patologia Clínica, Centro Hospitalar e Universitário de São João, Porto, Portugal, Sokhatska Oksana ,   Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina, Universidade do Porto, Portugal, Amorim Adelina ,   Serviço de Pneumologia, Centro Hospitalar e Universitário de São João, Faculdade de Medicina, Universidade do Porto, Portugal, Delgado Luís ,   Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina, Universidade do Porto, Portugal,   Laboratório de Imunologia, Serviço de Patologia Clínica, Centro Hospitalar e Universitário de São João, Porto, Portugal,   CINTESIS – Centro de Investigação em Tecnologias e Serviços de Saúde, Faculdade de Medicina, Universidade do Porto, Portugal
Published: December 2021

Os doseamentos séricos de anticorpos específicos para o Aspergillus fumigatus (A. fumigatus) são úteis para a orientação diagnóstica de aspergilose broncopulmonar alérgica (ABPA). Objetivo: Avaliar a sensibilização aos componentes purificados do A. fumigatus por quantificação de anticorpos específicos IgE e IgG no soro de doentes com ABPA ou com asma e sensibilização a fungos, usando como comparadores doentes com asma alérgica não sensibilizados a fungos, doentes com fibrose quística (FQ) sem critérios de ABPA e doentes com aspergiloma pulmonar. Métodos: Avaliação transversal de 57 doentes com os diagnósticos de ABPA (n=13), FQ (n=9), asma sensibilizada a fungos (ASF, n=10), asma alérgica sem sensibilização a fungos (AA, n=18) e aspergiloma (n=7). A determinação das concentrações séricas de IgE e IgG específica (sIgE e sIgG) para A. fumigatus (m3) e cinco dos seus componentes antigénicos recombinantes (rAsp f) rAsp f 1, rAsp f 2, rAsp f 3, rAsp f 4 e rAsp f 6 foi realizada por ImmunoCAP. Resultados: A ABPA diferiu significativamente da ASF, pela sensibilização (sIgE>0,10 kUA/L) ao antigénio intracelular rAsp f 6 (64% versus 0% Qui2=6,2, p=0,013) e pelo aumento significativo da sIgE para o antigénio extracelular rAsp f 1 (45,3; 0,2-33,7kUA/L versus 0,3; 0,1-0,3kUA/L, p=0,041). Os níveis de sIgG para A. fumigatus foram significativamente diferentes entre os grupos (p=0,002). No entanto, os níveis de sIgG para os rAsp f testados não diferiram entre ABPA, ASF, FQ e aspergiloma. Conclusão: A avaliação da resposta IgE ao A. fumigatus para alguns dos seus antigénios excretados (rAsp f 1) e intracelulares (rAsp f 6) parece útil na distinção serológica da ABPA em relação à ASF, permitindo melhorar a classificação dos doentes. Os níveis séricos de IgG para os rAsp f não distinguem os diferentes grupos de doentes sensibilizados, não melhorando a descriminação diagnóstica obtida utilizando o extrato total do A. fumigatus.
Brewing on an industrial and a craft scale – impact on the physicochemical properties and volatile compounds profile of the pale pilsener-style lager beer analysed with HS/GC-MS
Authors: Królak Kamil , Buła Maria
Published: December 2021

The pale Pilsener-style lager beers produced on a massive and craft scale were taken to analyse their basic physicochemical properties (alcohol content, pH, haze, real degree of fermentation) and volatile compounds profiles. The research was carried out using a beer analyser equipment and a headspace gas chromatography-mass spectrometry method (HS/GC-MS). The findings showed that in terms of physicochemical and flavour attributes, the quality of craft beers differed to a higher degree from the standard Pilsener beer quality than in the case of industrial beers.
Folk Devils and the Hipster Figure: On Classification Struggles, Social Types and Figures in Moral Panic Research
Authors: le Grand Elias
Published: December 2021

This chapter draws on a case study of contested societal reactions to the middle-class hipster figure and gentrification in contemporary London. The analysis shows how public reactions involve forms of class politics and classificatory struggles over the moral meaning gentrification processes and the role of the hipster figure in the latter. Through this, the chapter discusses how the folk devil can be conceptualized as a social type by drawing on Bourdieu’s research on classification.
Farklı Yıkama İşlemlerinin Üzümlerde Tebuconazole Kalıntısına Etkisi
Authors: DUMAN Ayşegül , ÇİFTÇİ Uğur , TİRYAKİ Osman
Published: December 2021

Bu çalışmada, üzümlerde tebuconazole kalıntılarının değişik yıkama yöntemleri ile giderilmesi araştırılmıştır. QuEChERS AOAC 2007.1 yönteminin üzümlerde tebuconazole kalıntı analizi için uygunluğu doğrulanmıştır. Bu amaçla metot doğrulama için (verification) hiçbir pestisit kalıntısı içermeyen üzümleri iyice homojenize edilmiş ve tebuconazole 0.05, 0.5 ve 5 mg/kg seviyelerinde spike edilmiştir. QuEChERS yöntemi, %6.33 standart sapma, %6.15 relatif standart sapma değeri ile %102.96 geri alım sağlamıştır (n=36). Bu bulgular SANTE geri alım limitleri (%60-140) ve tekrar edilebilirlik değerleri (RSD ≤ %20) ile uyumludur. Matrisli tebuconazole kalibrasyon eğrisi, 1-200 pg/µl sınırlarında doğrusaldır (R≥0.999). Tebuconazole’un LOQ değeri 1 µg/kg olarak bulunmuştur, bu da üzümlerdeki MRL değeri olan 500 µg/kg ın çok altındadır. Bağda tebuconazole etkili maddeli fungisit ile 4 defa ilaçlama yapılmış ve son ilaçlamanın 1., 3., 5., 7., ve 14. günlerinde hasat yapılmıştır. Üzümler yıkama uygulamalarına tabi tutulmuştur. Tebuconazole kalıntıları artan yıkama süreleri ile azalmıştır. Benzeri şekilde hasat dönemi ilerledikçe kalıntı giderme oranları azalmıştır. Kalıntı giderme oranı sırası, ultrasonik yıkama> asedik asit> sitrik asit> çeşme suyu şeklinde olmuştur. MRL’yi aşan kalıntılar, her 4 yıkama uygulamasında MRL’nin altına inmiştir.
Tarım Ekonomisi Bölümü Öğrencilerinin Yenilenebilir Enerji Kaynakları Hakkında Farkındalık Düzeyleri: Çanakkale Onsekiz Mart Üniversitesi
Authors: DURMUŞ Eylem , YÜCEER Sema Ezgi , TAN Sibel
Published: December 2021

Sanayileşmenin ve 1870’li yıllardan bu yana fosil yakıtların kullanımındaki artışın bir sonucu olarak bugün insanlık, küresel iklim değişikliği sorunuyla karşı karşıya bulunmaktadır. Küresel iklim değişikliği dünyayı tehdit eden çevre sorunlarının başında gelmekte olup sosyal, ekonomik ve ekolojik açıdan ele alınması gereken bir konudur. Sosyal boyutuyla ele alındığında, insanlardan çevre üzerine zararlı etkilerin azaltılması için davranışların değiştirilmesi konusunda farkındalık istenen yeni eğilimler söz konusudur. Bu bağlamda gençler, çevreye karşı geçmişteki ve halihazırdaki ihmallerin yükünü taşıdıkları için sürecin kritik paydaşları olmaktadırlar. Aynı zamanda davranış değişikliği ve aksiyon almada güçlü bir motoru temsil ederler. Bu nedenle gençler arasında çevre yanlısı davranışları inşa etmek sürdürülebilir bir gelecek yaratmak için kilit nokta olmaktadır. Niyet ve tutumların davranışa dönüştürülmesi noktasında farkındalık düzeyinin tespiti ilk adım olmaktadır. Bu amaçla söz konusu araştırma, Tarım Ekonomisi Bölümü öğrencilerinin yenilenebilir enerji kaynakları hakkında farkındalık düzeylerini belirlemek amacı taşımaktadır. Çalışmanın ana materyalini, Çanakkale Onsekiz Mart Üniversitesi, Ziraat Fakültesi, Tarım Ekonomisi Bölümü öğrencilerinden elde edilen birincil nitelikli veriler oluşturmaktadır. Bu kapsamda Basit Tesadüfi Örnekleme Yöntemi’ne 150 öğrenci ile anket yapılmıştır. Verilerin analizinde tanımlayıcı istatistiklerden yararlanılmış olup öğrencilerin yenilenebilir enerji kaynakları hakkında farkındalıklarını belirlemek amacıyla 5’li likert tipi ölçek kullanılmıştır. Sonuçlar, öğrencilerin yenilenebilir enerji kaynaklarına aşina olduklarını ancak biyoyakıtları yenilenebilir enerji kaynağı olarak tanımlama oranının daha düşük olduğunu göstermektedir. Ayrıca öğrenciler, yenilenebilir enerji kaynaklarının olası faydaları konusunda da tam bir fikre sahip değillerdir. Tarım Ekonomisi Bölümü ders planının; çevre eğitimi, yenilenebilir enerji teknolojileri ve yenilenebilir enerji kaynaklarına yönelik destekleyici tutumlar çerçevesinde şekillendirilmesinin öğrencilerin yenilenebilir enerji kaynakları hakkında daha derin bir anlayış kazanmalarını sağlayacağı düşünülmektedir.
Yarı Kurak Ekolojik Koşullar Altında Tarımsal Arazi Kullanım Planlamasının Hazırlanması: Ankara-Kalecik Örneği
Authors: TUNÇAY Tülay , SAYGIN Fikret , İMAMOĞLU Ali , DENGİZ Orhan , KEÇECİ Mehmet , USUL Mustafa , BAŞKAN Oğuz
Published: December 2021

Giderek artan dünya nüfusu, başta topraklar olmak üzere yenilenemez olan doğal kaynakların daha verimli kullanılma zorunluluğunu beraberinde getirmiştir. Arazi kullanım kararları başlangıçta arazi sahiplerinin kısa vadeli gereksinimleri doğrultusunda alınırken, günümüzde arazi kullanımın kararlarının doğal kaynaklara kalıcı zararlar vermeyecek şekilde alınabilmesi için arazi kullanım planlarının yapılması ve uygulamaya konulmasını gerektirmektedir. Her türlü arazi kullanım planlamasında birincil amaç, tarım topraklarının gelecek nesiller için korunarak sürdürülebilir kullanımı sağlamaktır. Bu nedenle, özellikle tarımsal arazi kullanım planlamaları toprakların özellik, dağılım ve potansiyellerinin belirlendiği temel toprak etüd ve haritalama çalışmalarına dayanarak yapılmaktadır. Planlama kararlarının sağlıklı olarak alınabilmesi amacıyla, yeterli doğrulukta ve ayrıntılı bilgileri içeren toprak etüd ve haritalama çalışmalarına ihtiyaç bulunmaktadır. Detaylı toprak haritaları esas alınarak yapılan arazi değerlendirme çalışmaları sonucu arazilerin alternatif kullanımlara uygunluğunun belirlenmesi ve uygun olan kullanımlardan planlama amaçlarıyla örtüşen ve sürdürülebilir kullanıma elverişli olanların seçilmesi planlamanın temelini oluşturmaktadır. Bu araştırma dijital alt yapılı güncellenebilir Türkiye topraklarının toprak etüt ve haritaların oluşturulmasına alt yapı oluşturması amacıyla Ankara ili Kalecik ilçesinde yürütülmüştür. Uydu görüntüleri, sayısal yükseklik modelleri, topoğrafik haritalar ve jeoloji haritaları kullanılarak toprak profil noktaları belirlenmiştir. Açılan profiller tanımlanarak taslak toprak haritası oluşturulmuş, daha sonra arazi gözlemleri ve örneklemeler ile seri sınırları kesinleştirilmiştir. İkinci aşamada arazi kullanım türleri, bu türlerin toprak istekleri belirlenerek toprak serileri özellikleri ile eşleştirme yapılmış ve toprak özelliklerine göre tarımsal arazi kullanım planlaması oluşturulmuştur.
Red Globe Üzüm Çeşidinde Farklı Anaç Kombinasyonlarının Açık Köklü Aşılı Fidan Randımanları Üzerine Etkileri
Authors: AKÇAMAN Sümeyya , DARDENİZ Alper
Published: December 2021

Bu araştırma, ‘Red Globe’ üzüm çeşidinde farklı anaç kombinasyonlarının açık köklü aşılı fidan randımanları üzerine etkilerinin belirlenmesi amacıyla 2016 yılında, Manisa ilindeki ‘Çalışkan Asma Fidancılığı’ işletmesinde yürütülmüştür. Araştırmada ‘Red Globe’ üzüm çeşidinin kalemleri, ‘5BB’, ‘41B’, ‘110R’, ‘1103P’ ve ‘1613C’ anaçlarının aşılanabilir çelikleri üzerine masa başı omega aşı yöntemiyle aşılanmıştır. Araştırma 3 tekerrürlü ve her bir tekerrürde 50’şer adet aşılı çelik yer alacak şekilde planlanmıştır. En yüksek fidanlık randımanı Red Globe/110R (%76,00), en düşük fidanlık randımanı Red Globe/41B (%44,67) çeşit/anaç kombinasyonunda, en yüksek 1. boy aşılı asma fidanı randımanı Red Globe/110R (%53,33), en düşük 1. boy aşılı asma fidanı randımanları ise sırasıyla Red Globe/41B (%30,00), Red Globe/5BB (%30,00) ve Red Globe/1103P (%36,00) çeşit/anaç kombinasyonlarında tespit edilmiştir.
The Ufi Gel P (VOCO) aplication for the correction of the resection prosthesis in an orthopaedic rehabilitation of a patient with a postoperative upper jaw defect of oncological origin. Clinical case
Authors:   National Medical University. O.O. Bogomolets, Kyiv, Ukraine, Symonenko R.
Published: December 2021

Summary. The prevalence of malignant neoplasms of the oral cavity occupies a significant place in the structure of oncological diseases while the cancer treatment is mainly complex and radical. Reconstructive surgery is most often associated with removable dentures. The patients after an upper jaw resections take a significant part of patients with postoperative defects. There is still no consensus between the specialists on prosthetics for patients after resection of the upper jaw of oncological origin. The literature shows a large number of problems, the main one is the lack of data on the long-term outcome of the prosthesis of these patients, the «temporality» of the prosthetic constructions and the poor prognosis. From this point of view, the use of high quality elastic materials is a successful for current problems resolution. The work describes the correction method of an upper jaw resection prosthesis by means of an elastic pad. The high-potency of the Ufi Gel P VOCO (Germany), A-silicone based material, was demonstrated for the clinical relining of resection prosthesis in distant future. We succeeded to achieve effective denture adhesion by correcting the peripheral flap along the transitory fold and the A-line with Ufi Gel P elastic material. The elastic correction of resection prosthesis allows to provide emergency help, makes the use of the prosthesis more comfortable, catalyzes the adaptation and has a positive impact on the social rehabilitation of cancer patients. Key words: elastic pad, upper jaw resection prosthesis, post-resection distant ptosthetics.
Restoration of oral health as one of the important factors improving the quality of life
Authors:   National Medical University. O.O. Bogomolets, Kyiv, Ukraine, Zhachko N. , Nespriad’ko-Monborgne T. ,   National Medical University. O.O. Bogomolets, Kyiv, Ukraine, Skrypnyk I. ,   National Medical University. O.O. Bogomolets, Kyiv, Ukraine, Zhachko M. ,   Smile Time Medical Center, Kyiv, Ukraine
Published: December 2021

Summary: The search for and development of methods for determining the quality of life is an urgent problem of foreign and domestic medicine, and the state of dental health plays a very important role. An important role in human communication plays the maxillofacial area. Therefore, the most important areas and defects associated with the communication process – defects in the frontal area, smile, change of pronunciation, spitting during the conversation – all these signs accompany a number of anomalous processes. Objective: to assess the impact of dental status on the quality of life of the adult population in the presence of the disease periodontal disease in combination with musculoskeletal dysfunction in patients with dental anomalies and deformities. Materials and methods. To study this goal, a survey of 283 patients who applied was conducte with complaints of aesthetic defect of the dentition, combined with the presence of joint pain and periodontal disease of varying severity. Results. A complete analysis of factors that significantly affected the quality of life of patients with a number of diseases was obtained oral cavity. Conclusions. Deficiencies related to oral health reduce the quality of life of our patients, and the treatment significantly changes its quality depending on age, sex and method. But for the best results positive changes in the quality of life of the patient dentists can expect only by conducting a comprehensive treatment. Key words: quality of life, dental health correction.
The effect of microstructure of the surface, the design and dimension of dental implants on their stability and the process of osteointegration during immediate and delayed implantation. PartII
Authors:   FSBEI VO Kazan State Medical University of the Ministry of Health of Russia, Kazan, Russia, Grishin P. , Mamaeva E. ,   FSBEI VO Kazan State Medical University of the Ministry of Health of Russia, Kazan, Russia, Kalinnikova E. ,   FSBEI VO Kazan State Medical University of the Ministry of Health of Russia, Kazan, Russia, Kozlov A. ,   GU "Institute of Dentistry and Oral and Maxillofacial Surgery NAMNU", Odessa, Ukraine, Kushner E. ,   ONMedU, Odessa, Ukraine, Chigarina C. ,   FSBEI VPO Samara State Medical University of the Ministry of Health of Russia, Samara, Russia
Published: December 2021

Abstract. This article presents the results of a clinical study of the stability and process of osteointegration implants of 11 known implant dental systems. The effect of the microstructure of 3 types of implant surface (HSTTM, SLA and RBM) and their design features (shape, size, type of carving) on the indicators of their stability and osteointegration process during immediate and delayed implantation with immediate functional load is shown and analyzed. The stability of the implants and the dynamics of the quality of osteointegration were determined by the devices «Osstell Mentor» and «Periotest» in the process of treatment, starting from the moment of implant installation in different eras (2 weeks, 1 month, 2 months and 3 months). 414 patients between the ages of 20 and 70 were monitored. Of these, there are 249 and 165 male women. The average age of the operated patients was: for men – 54 years for women – 49 years. All patients were divided into two groups of the first – 109 patients who after extraction were directly implanted into the hole of the remote tooth with the subsequent immediate load, the second group – 305 patients who were delayed implantation with immediate load. A total of 1,302 implants were installed. The study revealed a link between the type of surface of the implant, primary stability and the time of its osteointegration during certain periods of clinical observation. The results of the study demonstrated the important role of combining microstructure of the surface, design and dimension features, the type of insertion of implants on their primary stability and the process of osteointegration in the conduct of both immediate and delayed implantation. Key words: frequency resonance analysis, damping, stability, osteointegration, fixation, implants, periotestometry, immediate implantation.
The repair of chipped ceramics with the direct adhesive technique of self-adhesive system for fixing on a composite basis BIFIX SE (VOCO, Germany). The clinical case
Authors:   National Medical University. O.O. Bogomolets, Kyiv, Ukraine, Symonenko R.
Published: December 2021

Summary. The single chips of ceramic structures remain a big problem for both the patient and for the doctor, especially in the frontal area, when for some objective reason, they cannot immediately change the construction. The work is justified by the choice of materials and the method of direct restoration of a single defect is described on a zirconium basis using the BIFIX SE self-adhesive system and the Futurabond U universal adhesive (VOCO, Germany). The repair of chipped ceramics is a real necessity. And the durability of restorations directly depends on the compliance with adhesive work technique, as well as the analysis of the reasons leading to the destruction of the ceramic mass and following up the patient's regime. Key words: the chipped ceramics, direct restoration, adhesive technique, self-adhesive system for fixing.
Comparative characteristics of dynamic masticatory tests
Authors:   Vinnytsia National Medical University named after E. Pirogov, Vinnytsia, Ukraine, Kushta A.
Published: December 2021

Summary. Chewing is one of the important functions of a person that ensures vital functions. Many works have been devoted to the definition of chewing efficiency for almost a hundred years. However, most of them are not currently used, which is due to the complexity and complexity of the implementation. This review is devoted to the coverage and comparison of dynamic masticatory samples to select the optimal for use in patients in the postoperative period with defects of the oral cavity and oropharynx. Key words: chewing efficiency, dynamic test, oral cavity defects.
A extensão universitária como agente transformadora da sociedade: estudo de caso da Biblioteca Comunitária do bairro Saramenha de Cima - Ouro Preto/MG
Authors: Figueiredo Thiago Duarte , Alves Caio Cesar Gonzaga , Souza Crislaine , Rodrigues Guilherme Henrique Gualandi , Pereira Carlos Alberto
Published: December 2021

As bibliotecas comunitárias são ambientes sociais criados pela própria comunidade para promover acesso à informação e lazer à população local. Esses ambientes se tornam importantes pontos de apoio, reduzindo desigualdades sociais e garantindo o desenvolvimento pedagógico e cultural. Nesse contexto, no ano de 2005, foi criada a Biblioteca Comunitária de Saramenha de Cima, no bairro de mesmo nome na cidade de Ouro Preto-MG, numa parceria entre grupos locais e Universidade Federal de Ouro Preto (UFOP). A biblioteca promove atividades de estímulo à leitura, oficinas, reforço escolar e empréstimos de livros, com participação de alunos de extensão universitária dos cursos de graduação da UFOP nas atividades do projeto.  Esse artigo avalia o impacto da Biblioteca Comunitária de Saramenha de Cima na melhoria da educação e qualidade de vida da população local, por meio de levantamento de dados de desempenho escolar das crianças participantes, análises dos principais pontos de transformação do projeto na comunidade e no desenvolvimento pessoal e acadêmico dos extensionistas. O estudo destacou como o projeto trouxe o sentimento de orgulho e pertencimento à população local, se tornando ponto de lazer, cultura e, principalmente, desenvolvimento educacional, com a escola do bairro obtendo crescente rendimento acadêmico com apoio da biblioteca, obtendo resultados superiores as médias municipal, estadual e nacional. Além disso, o projeto promove a aproximação entre a comunidade e a universidade, garantindo também um amadurecimento pessoal importantíssimo aos extensionistas participantes, preparando os   no âmbito acadêmico, com apresentação de trabalhos relacionados e tornando-os mais humanos e melhor preparados para o futuro.
Microbial communities (bacteria, archaea and eukaryotes) in a temperate estuary during seasonal hypoxia
Authors: Santoferrara LF , McManus GB , Greenfield DI , Smith SA
Published: December 2021

Eutrophication and hypoxia markedly alter trophic dynamics and nutrient cycling in estuarine water columns, but little is known about the microbial communities that drive and interact with these changes. Here we studied microbial plankton (bacteria, archaea, protists and micro-metazoans) in a large temperate estuary where bottom hypoxia occurs every summer due to warmer temperatures, stratification, and oxidation of organic matter fueled by nutrient enrichment. We used high-throughput sequencing of the 16S and 18S rRNA genes (V4 region) and quantified multiple abiotic and biotic factors in surface and bottom waters during the summer of 2019. The conditions associated with the intensification of hypoxia in bottom waters as the summer progressed were linked to significant changes in the diversity, community structure and potential functioning of microbial communities. Under maximum hypoxia (dissolved oxygen concentration: 0.9-3.1 mg l-1), there were increased proportions of ammonia-oxidizing archaea (AOA), bacterivorous and parasitic protists, and copepod nauplii. Sequence proportions of AOA (Nitrosopumilus) and nitrite-oxidizing bacteria (Nitrospinaceae) were significantly correlated with the concentration of oxidized N species (nitrite plus nitrate, which peaked at 14.4 µM) and the proportions of nauplii DNA sequences and biomass. Our data support a tight coupling of biogeochemical and food web processes, with rapid oxidation of ammonia and accumulation of oxidized N species as hypoxia intensifies during the summer.
The Long-Term Effects of Growth Hormone Replacement on Bone Mineral Density and Trabecular Bone Score: Results of the 10-Year Prospective Follow-up
Authors: Vaňuga P. , Kužma M. , Stojkovičová D. , Smaha J. , Jackuliak P. , Killinger Z. , Payer J.
Published: December 2021

There are only few studies concerning about long-term effect of growth hormone (GH) replacement therapy on bone mineral density and bone microstructure. To assess effect of GH replacement therapy on bone mineral density (BMD) and trabecular bone score (TBS) in adult GH deficient (AGHD) subjects over period of 10 years. From 2005 to 2018,
a prospective study of AGHD patients was conducted in national referral center for treatment of GHD. All patients received subcutaneous recombinant human GH in an IGF 1-normalizing regimen once a day. Lumbar spine (L-spine) and total hip (TH) BMD using Hologic densitometers were measured at baseline and every two years during treatment with rhGH. TBS was derived from L1-L4 DXA using iNsight® software (Medimaps, France) at each time point. Periods of measurement were baseline, year 2; 4; 6; 8 and 10. In total, 63 patients (38 males, 25 females, mean age 25.1±16 years) were included in the study. After 10 years of GH treatment, IGF-1 significantly increased (~35 %), with greatest increase at year 2. During 10-year follow-up, L-spine BMD increased approximately of 7 % (NS). TH BMD increase of 11 % during follow-up (p=0.0003). The greatest increment of BMD was achieved at year 6 on both sites, L-spine (+6 %) and TH BMD (+13 %) (p<0.05). There was no significant change of TBS during whole follow-up. In this study, sustaining positive effect of GH replacement therapy on bone density in subjects with adult GH deficiency over 10 years of follow-up was observed. The study did not show effect on TBS, as indirect measure of trabecular bone microarchitecture.
Epstein–Barr Virus-Induced Acute Hepatitis, Pancreatitis, and Pneumonitis in a Young
Immunocompetent Adult: A Case Report
Authors: Fiani Elias , Challita Rafca , Badawaki Hanaa , Soukarieh Khaled , Kyriakos Saad Melissa , Saikaly Elias
Published: December 2021

Epstein–Barr virus (EBV) is a common herpes virus (human herpesvirus type 4) that usually manifests as infectious mononucleosis or persists asymptomatically for life. EBV can also be associated with different types of malignancy such as T cell lymphoma, B cell lymphoma, Hodgkin lymphoma, and oropharyngeal squamous cell and nasopharyngeal carcinoma. Pneumonia is a very rare complication of EBV infection, but it has been reported to occur even in the absence of mononucleosis.

This article highlights the case of 35-year-old female who developed acute pancreatitis and acute respiratory failure related to EBV infection. The patient progressively recovered on antiviral therapy and steroids.
Klasifikasi Penyakit Pada Citra Daun Jeruk Menggunakan Arsitektur MobileNet berbasis Mobile Platform
Authors: Riswandi Riswandi , Jamiah Rosmiati , Mardhatillah Nisa , Hamid Hady Prasetya
Published: December 2021

Proses diagnosa penyakit pada tanaman daun jeruk umunya dilakukan melalui pemeriksaan laboratorium oleh seorang ahli patologi tumbuhan dengan melihat gejala visual yang timbul pada tanaman untuk membantu petani daun jeruk dalam memberikan pola penanganan yang tepat berdasarkan gejala yang nampak pada kondisi daun jeruk. Klasifikasi penyakit daun jeruk menggunakan metode pengolahan citra mampu memberikan referensi diagnosis yang cepat dan akurat. Penelitian ini mengusulkan pendekatan deep learning menggunakan arsitektur MobineNet CNN untuk melakukan klasifikasi. Metode pada penelitian ini dievaluasi pada citra penyakit daun jeruk dalam tiga kategori yaitu normal, HLB dan CTV dengan ukuran citra 150x150. Pengujian dilakukan dengan menggunakan algortima RMSprof optimize dengan learning rate 0.001. Proses pelatihan  menggunakan arsitektur Binary Cross Entropy fungsi aktivasi sigmoid. Hasi klasifikasi penyakit pada citra daun jeruk pada proses training mencapai tingkat akurasi 98% pada epoch 15.
The Future of Personalized Medicine in Space: From Observations to Countermeasures
Authors: Pavez Loriè Elizabeth , Baatout Sarah , Choukér Alexander , Buchheim Judith-Irina , Baselet Bjorn , Dello Russo Cinzia , Wotring Virginia , Monici Monica , Morbidelli Lucia , Gagliardi Dimitri , Stingl Julia Caroline , Surdo Leonardo , Yip Vincent Lai Ming
Published: December 2021

The aim of personalized medicine is to detach from a “one-size fits all approach” and improve patient health by individualization to achieve the best outcomes in disease prevention, diagnosis and treatment. Technological advances in sequencing, improved knowledge of omics, integration with bioinformatics and new in vitro testing formats, have enabled personalized medicine to become a reality. Individual variation in response to environmental factors can affect susceptibility to disease and response to treatments. Space travel exposes humans to environmental stressors that lead to physiological adaptations, from altered cell behavior to abnormal tissue responses, including immune system impairment. In the context of human space flight research, human health studies have shown a significant inter-individual variability in response to space analogue conditions. A substantial degree of variability has been noticed in response to medications (from both an efficacy and toxicity perspective) as well as in susceptibility to damage from radiation exposure and in physiological changes such as loss of bone mineral density and muscle mass in response to deconditioning. At present, personalized medicine for astronauts is limited. With the advent of longer duration missions beyond low Earth orbit, it is imperative that space agencies adopt a personalized strategy for each astronaut, starting from pre-emptive personalized pre-clinical approaches through to individualized countermeasures to minimize harmful physiological changes and find targeted treatment for disease. Advances in space medicine can also be translated to terrestrial applications, and vice versa. This review places the astronaut at the center of personalized medicine, will appraise existing evidence and future preclinical tools as well as clinical, ethical and legal considerations for future space travel.
Reliability Quantification of Railway Electrification Mast Structure Considering Buckling
Authors: Kaewunruen Sakdirat , Ngamkhanong Chayut , Ren Lichen
Published: December 2021

This paper aims to quantify and assess the reliability of mast structures as a part of ensuring structure safety. The mast structure is a basic aspect of the overhead line electrification equipment (OHLE) used in railway systems. This structure is very important as the failure of structure leads to the failure of an electric system that supplies the power to the train. To ensure structural safety and reliability, this paper thus analyses the reliability index of the mast, stay tube, and bracket tube structures. According to Eurocode, buckling resistance under compression of these parts were calculated based on specific material properties, and the load condition of these structures is based on Australian Railcorp document TMC331. In this paper, the strength load combination with the wind loading on the wire at 45° on the track is considered in particular as being the worst load combination for structures to bear, and the random variables used to affect reliability probabilistic analysis. Various parameters including self-weight, wind load, dimension parameters, materials, geometrical properties are taken into consideration. Statistical models of these parameters are taken from previous studies. The reliability index value was calculated via quantification of structure reliability using the first-order reliability method (FORM). Finally, a sensitivity analysis is used to evaluate the impacts of yield strength, length, cross-section, density, and load combination on reliability. The obtained results show that increasing length of structure can potentially reduce the reliability of mast structure to buckling resistance while the density of material also plays a major role in the reliability index. The findings will provide the structural safety criteria of the railway mast structure and improve the standard design to mitigate the risks and unplanned maintenance due to the uncertainties.
Solar Dollars: A Complementary Currency that Incentivizes Renewable Energy
Authors: Greco Thomas H.
Published: December 2021

Incentives are the key to addressing climate change and the various other aspects of the current multi-dimensional mega-crisis. This paper proposes the issuance of private community currency vouchers by electric utility companies based on their willingness and ability to provide their customers with energy derived from renewable sources. By monetizing the value of renewable energy in the form of a community currency Solar Dollars help to solve several critical problems at once: They incentivize a more rapid shift to renewable energy, help communities to become more resilient and self-determined, and enable the decentralization of economic and political power.
Mass Transfer in Hierarchical Silica Monoliths Loaded With Pt in the Continuous-Flow Liquid-Phase Hydrogenation of p-Nitrophenol
Authors: Jatoi Haseeb Ullah Khan , Goepel Michael , Poppitz David , Kohns Richard , Enke Dirk , Hartmann Martin , Gläser Roger
Published: December 2021

Sol-gel-based silica monoliths with hierarchical mesopores/macropores are promising catalyst support and flow reactors. Here, we report the successful preparation of cylindrically shaped Pt-loaded silica monoliths (length: 2 cm, diameter: 0.5 cm) with a variable mean macropore width of 1, 6, 10, or 27 μm at a fixed mean mesopore width of 17 nm. The Pt-loaded monolithic catalysts were housed in a robust cladding made of borosilicate glass for use as a flow reactor. The monolithic reactors exhibit a permeability as high as 2 μm2 with a pressure drop below 9 bars over a flow rate range of 2–20 cm3 min−1 (solvent: water). The aqueous-phase hydrogenation of p-nitrophenol to p-aminophenol with NaBH4 as a reducing agent was used as a test reaction to study the influence of mass transfer on catalytic activity in continuous flow. No influence of flow rate on conversion at a fixed contact time of 2.6 s was observed for monolithic catalysts with mean macropore widths of 1, 10, or 27 µm. As opposed to earlier studies conducted at much lower flow velocities, this strongly indicates the absence of external mass-transfer limitations or stagnant layer formation in the macropores of the monolithic catalysts.
Vitamin E Acetate Determination in Vaping Liquids and Non-targeted Analysis of Vaping Emissions of Diluents of Concern, Vitamin E Acetate and Medium-Chain Triglycerides Oil
Authors: Kosarac Ivana , Kubwabo Cariton , Katuri Guru Prasad , Petraccone Dora , Mischki Trevor K.
Published: December 2021

During the summer of 2019, cases of lung injury associated with vaping emerged in North America, including among individuals who reported exclusive use of nicotine vaping liquids. Once vitamin E acetate was identified as a potential causative agent a quantitative method based on a simple sample dilution, separation by gas chromatography and analysis by triple quadrupole mass spectrometry (GC MSMS) was developed. Method detection limit (MDL) and limit of quantification (LOQ) were determined at 0.159 µg/mL and 0.505 µg/mL, respectively. The analysis was performed on a subset of 203 commercially sourced nicotine containing vaping liquids of various flavour profile and nicotine range (nicotine free-59 mg/mL) from an internal inventory. The target analyte, Vitamin E Acetate, was not detected in any samples analyzed, as expected, given the reported detection in literature and high association of the chemical with cannabis and not nicotine containing vaping products.
Construction of UiO-66/Bi4O5Br2 Type-II Heterojunction to Boost Charge Transfer for Promoting Photocatalytic CO2 Reduction Performance
Authors: Li Dongsheng , Zhu Bichen , Sun Zhongti , Liu Qinqin , Wang Lele , Tang Hua
Published: December 2021

One of the basic challenges of CO2 photoreduction is to develop efficient photocatalysts, and the construction of heterostructure photocatalysts with intimate interfaces is an effective strategy to enhance interfacial charge transfer for realizing high photocatalytic activity. Herein, a novel UiO-66/Bi4O5Br2 heterostructure photocatalyst was constructed by depositing UiO-66 nanoparticles with octahedral morphology over the Bi4O5Br2 nanoflowers assembled from the Bi4O5Br2 nanosheets via an electrostatic self-assembly method. A tight contact interface and a built-in electric field were formed between the UiO-66 and the Bi4O5Br2, which was conducive to the photo-electrons transfer from the Bi4O5Br2 to the UiO-66 and the formation of a type-II heterojunction with highly efficient charge separation. As a result, the UiO-66/Bi4O5Br2 exhibited improved photocatalytic CO2 reduction performance with a CO generation rate of 8.35 μmol h−1 g−1 without using any sacrificial agents or noble co-catalysts. This work illustrates an applicable tactic to develop potent photocatalysts for clean energy conversion.
Phosphoproteomic Analysis Reveals Downstream PKA Effectors of AKAP Cypher/ZASP in the Pathogenesis of Dilated Cardiomyopathy
Authors: Lv Jialan , Pan Zhicheng , Chen Jian , Xu Rui , Wang Dongfei , Huang Jiaqi , Dong Yang , Jiang Jing , Yin Xiang , Cheng Hongqiang , Guo Xiaogang
Published: December 2021

Background: Dilated cardiomyopathy (DCM) is a major cause of heart failure worldwide. The Z-line protein Cypher/Z-band alternatively spliced PDZ-motif protein (ZASP) is closely associated with DCM, both clinically and in animal models. Our earlier work revealed Cypher/ZASP as a PKA-anchoring protein (AKAP) that tethers PKA to phosphorylate target substrates. However, the downstream PKA effectors regulated by AKAP Cypher/ZASP and their relevance to DCM remain largely unknown.

Methods and Results: For the identification of candidate PKA substrates, global quantitative phosphoproteomics was performed on cardiac tissue from wild-type and Cypher-knockout mice with PKA activation. A total of 216 phosphopeptides were differentially expressed in the Cypher-knockout mice; 31 phosphorylation sites were selected as candidates using the PKA consensus motifs. Bioinformatic analysis indicated that differentially expressed proteins were enriched mostly in cell adhesion and mRNA processing. Furthermore, the phosphorylation of β-catenin Ser675 was verified to be facilitated by Cypher. This phosphorylation promoted the transcriptional activity of β-catenin, and also the proliferative capacity of cardiomyocytes. Immunofluorescence staining demonstrated that Cypher colocalised with β-catenin in the intercalated discs (ICD) and altered the cytoplasmic distribution of β-catenin. Moreover, the phosphorylation of two other PKA substrates, vimentin Ser72 and troponin I Ser23/24, was suppressed by Cypher deletion.

Conclusions: Cypher/ZASP plays an essential role in β-catenin activation via Ser675 phosphorylation, which modulates cardiomyocyte proliferation. Additionally, Cypher/ZASP regulates other PKA effectors, such as vimentin Ser72 and troponin I Ser23/24. These findings establish the AKAP Cypher/ZASP as a signalling hub in the progression of DCM.
Comparison of Empirical Mode Decomposition, Wavelets, and Different Machine Learning Approaches for Patient-Specific Seizure Detection Using Signal-Derived Empirical Dictionary Approach
Authors: Kaleem Muhammad , Guergachi Aziz , Krishnan Sridhar
Published: December 2021

Analysis of long-term multichannel EEG signals for automatic seizure detection is an active area of research that has seen application of methods from different domains of signal processing and machine learning. The majority of approaches developed in this context consist of extraction of hand-crafted features that are used to train a classifier for eventual seizure detection. Approaches that are data-driven, do not use hand-crafted features, and use small amounts of patients' historical EEG data for classifier training are few in number. The approach presented in this paper falls in the latter category, and is based on a signal-derived empirical dictionary approach, which utilizes empirical mode decomposition (EMD) and discrete wavelet transform (DWT) based dictionaries learned using a framework inspired by traditional methods of dictionary learning. Three features associated with traditional dictionary learning approaches, namely projection coefficients, coefficient vector and reconstruction error, are extracted from both EMD and DWT based dictionaries for automated seizure detection. This is the first time these features have been applied for automatic seizure detection using an empirical dictionary approach. Small amounts of patients' historical multi-channel EEG data are used for classifier training, and multiple classifiers are used for seizure detection using newer data. In addition, the seizure detection results are validated using 5-fold cross-validation to rule out any bias in the results. The CHB-MIT benchmark database containing long-term EEG recordings of pediatric patients is used for validation of the approach, and seizure detection performance comparable to the state-of-the-art is obtained. Seizure detection is performed using five classifiers, thereby allowing a comparison of the dictionary approaches, features extracted, and classifiers used. The best seizure detection performance is obtained using EMD based dictionary and reconstruction error feature and support vector machine classifier, with accuracy, sensitivity and specificity values of 88.2, 90.3, and 88.1%, respectively. Comparison is also made with other recent studies using the same database. The methodology presented in this paper is shown to be computationally efficient and robust for patient-specific automatic seizure detection. A data-driven methodology utilizing a small amount of patients' historical data is hence demonstrated as a practical solution for automatic seizure detection.
Data in Schools: (Changing) Practices and Blind Spots at a Glance
Authors: Krein Ulrike , Schiefner-Rohs Mandy
Published: December 2021

This review aims to provide a concise overview of the role of (digital) data and new data practices in schools. By focusing on the impact of data on pedagogical practices, it aims to shed light on how the everyday tasks of teachers and other pedagogical staff in schools are changing, particularly as a result of the generation and use of digital data. For this purpose, existing studies and previous theoretical debates on this topic are examined for their perspectives on data and data practices in schools. The pedagogical data practices of (improving) teaching and learning, assessment and counseling, (data-driven) decision-making, and cooperation and collaboration by “doing data” will be elaborated and discussed. Likewise, data practices that are missing from the studies are identified. We conclude with an overview of blind spots and further research needs.
Individual and Combined Associations of Glucose Metabolic Components With Cognitive Function Modified by Obesity
Authors: He Ruixin , Zheng Ruizhi , Li Jie , Cao Qiuyu , Hou Tianzhichao , Zhao Zhiyun , Xu Min , Chen Yuhong , Lu Jieli , Wang Tiange , Xu Yu , Bi Yufang , Wang Weiqing , Li Mian , Liu Yan , Ning Guang
Published: December 2021

Aim

We aimed to detect the individual and combined effect of glucose metabolic components on cognitive function in particular domains among older adults.

Methods

Data of 2,925 adults aged over 60 years from the 2011 to 2014 National Health and Nutrition Examination Survey were analyzed. Individuals’ cognitive function was evaluated using the Digit Symbol Substitution Test (DSST), the Animal Fluency Test (AF), the Consortium to Establish a Registry for Alzheimer’s Disease Immediate Recall (CERAD-IR), and CERAD Delayed Recall (CERAD-DR). Participants’ glucose metabolic health status was determined based on fasting plasma glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), and 2-h postload glucose. Linear regression models were used to delineate the associations of cognitive function with individual glucose metabolic component and with metformin use. Logistic regression models were performed to evaluate the associations of cognition with the number of glucose metabolic risk components.

Results

CERAD-IR was significantly associated with HOMA-IR and insulin. HbA1c was related to all the cognitive tests except AF. Among participants without obesity, HOMA-IR and insulin were both negatively associated with CERAD-IR and CERAD-DR. Odds of scoring low in DSST increased with the number of glucose metabolic risk components (odds ratio 1.94, 95% confidence interval [CI] 1.26 to 2.98). Metformin use was associated with better performance in DSST among diabetes patients (β = 4.184, 95% CI 1.655 to 6.713).

Conclusions

Our findings support the associations of insulin resistance and glycemic level with cognitive function in key domains, especially among adults without obesity. There is a positive association between metformin use and cognition.
Association of Quantified Costal Cartilage Calcification and Long-Term Cumulative Blood Glucose Exposure: The Multi-Ethnic Study of Atherosclerosis
Authors: Shabani Mahsima , Pishgar Farhad , Akhtarkhavari Sepehr , Quinaglia Thiago , Budoff Matthew J. , Bluemke David A. , Barr Graham R. , Post Wendy S. , Wu Colin O. , Arbab-Zadeh Armin , Sidhaye Aniket , Lima João A. C. , Demehri Shadpour
Published: December 2021

Aims

Anecdotal reports have suggested increased soft tissue calcification in individuals with long-term exposures to high blood glucose. The association of costal cartilage calcification (CCC), a reliably quantifiable marker obtainable from non-contrast cardiac computed tomography (CT) with cumulative fasting blood glucose (FBG) exposure, is unknown. In this study, we aimed to determine the association between quantified CCC and cumulative glucose exposure using non-contrast coronary artery calcium (CAC) scoring computed tomography (CT) images in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods

The volume of bilateral CCC was quantified in high-density pixels (threshold of Hounsfield Unit>180) using the CAC scoring CT images acquired in the 5th MESA exam. Prior long-term cumulative exposure to FBG was calculated by area under the FBG-time curve over ten years before the time of the CT exam.

Results

A total of 2,305 participants (mean age: 69, female/male: 1.3) were included in this study. The median CCC volume was lower in females than males (1158 mm3 [IQR: 1751] vs. 3054 mm3 [3851], p<0.001). In cross-sectional analysis, quantified CCC was associated with FBG (9% increase per SD) and HbA1c (7% increase per SD) at the CT exam only in female participants after adjustment for age, race, BMI, and glomerular filtration rate. Only in female participants, quantified CCC was also associated with prior cumulative FBG (3% increase per decile change). In the subgroup of females with zero CAC scores, the adjusted CCC was still associated with FBG (13% increase per SD) at the time of CT exam and with prior cumulative FBG exposure (4% increase per decile change) before the CT exam.

Conclusions

The CCC, a reliably quantified marker in non-contrast cardiac CT, is associated with 10-year cumulative FBG exposure only in female participants, even those with zero CAC.
Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent
Authors: Wendt Frank R , De Lillo Antonella , Pathak Gita A , De Angelis Flavio ,   COVID-19 Host Genetics Initiative, Polimanti Renato
Published: December 2021

Risk factors and long-term consequences of COVID-19 infection are unclear but can be investigated with large-scale genomic data. To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N > 1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use (genetic causality proportion (gĉp) with severe respiratory COVID-19 = 0.576, p = 1.07 × 10−5 and hospitalized COVID-19 = 0.713, p = 0.003), and alcohol drinking status (gĉp with severe respiratory COVID-19 = 0.633, p = 7.04 × 10−5 and hospitalized COVID-19 = 0.848, p = 4.13 × 10−13). COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors and potential long-term health effects of severe response to infection.