bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of tourniquet technique on postoperative delirium in elderly patients with total knee arthroplasty: A Randomized Controlled Trial
Authors: ran wei , Li Shuzhen , Yuan Ruixue , Luo Huan , Li Ping , Gao Jin
Published: March 2022

Background: Tourniquet technique is often used in total knee arthroplasty (TKA), However, the effect on postoperative delirium (POD) in elderly patients with TKA procedure is still unknow.Methods: This prospective randomized controlled study assessed eligibility of 245 elderly patients, 197 patients met the inclusion criteria were randomly divided into tourniquet group (n=98) and non-tourniquet group (n=99). The primary outcome was the incidence of POD within 72 hours after surgery. The secondary outcome was the quality of rehabilitation, including inflammatory reaction, postoperative pain, hypoproteinemia and anemia.Results: Of 245 patients, 184 patients completed this clinical trial, 92 cases in each group. There were 14 patients (15.22%) with POD in tourniquet group and 5 patients (5.43%) in non-tourniquet group (95%CI 1.076 to 9.067, P=0.029). The changes of WBC, NEUT%, CRP, IL-6 and middle patellar circumference in tourniquet group were higher than those in non-tourniquet group (F=5.136, P=0.025 F=17.213, P<0.001 F=9.055, P=0.003 F=552.793, P<0.001 F=153.839, P<0.001). VAS at resting and activity in tourniquet group were higher than those in non-tourniquet group (F=170.102, P<0.001 F=75.391, P<0.001). There were 41 (44.57%) patients with hypoproteinemia in tourniquet group and 26 (28.26%) patients in non-tourniquet group (95%CI 1.106 to 3.765, P=0.022). Conclusion: The application of tourniquet technique in elderly patients with TKA procedure increased the incidence of POD, which may attribute to the increased inflammatory reaction, severe postoperative pain and hypoproteinemia caused by tourniquet technique. Trial registration: This prospective study (Ethics Committe and IRB number: 2019-338) was approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University ,Chongqing, China (Chairperson Prof Hao Jie) on 23 April 2021 and registered at the Chinese Clinical Trial Registry (http://www.chictr.org.cn, Chictr2100045711) before the enrolment process started on 28 April 2021, The study adhered to the CONSORT guidelines and written informed consent was obtained from all subjects participating in the trial.
Dynamic Data Collection Algorithm based on Mobile Edge Computing in Underwater Internet of Things
Authors: Liu Chunfeng , Guang Xiaoyun , Qu Wenyu , Zhao Zhao
Published: March 2022

The Underwater Internet of Things (UIoT) hasemerged as one of the prominent technologies in the developmentof future ocean monitoring systems, where mobile edge elements(such as autonomous underwater vehicles, AUVs) provide apromising method for the data collection from sensor nodes.However, as an important part of the UIoT, underwater wirelesssensor networks (UWSNs) are severely affected by the underwater dynamic environment. For instance, node locations changecontinuously, which significantly increases the difficulty of datacollection. To solve this problem, the concept of an inevitablecommunication space (ICS) is proposed. The ICS is calculatedby analyzing the variation in the position of nodes and thecommunication range. Furthermore, an ICS-based dynamic datacollection algorithm (ICS-DDCA) for UIoT is proposed to collectunderwater data. This method utilizes the ICS instead of theinitial location of the node for data collection to further improvethe performance of the algorithm and shorten the data collectiontime. The simulation results demonstrate that the ICS-DDCAcan effectively reduce the collection time, while ensuring the fullcompletion of data collection. Compared to EEDA and PNCS-GHA, ICS-DDCA reduces the time required for data collectionby 24.15% and 24.22% on the average respectively.
Stone catcher device to improve management of urolithiasis. Calculstop Trial
Authors: Giaime Philippe , Pedinielli Nathalie , Chaumoitre Jérémie , Mustat Andrea , Sampol Jérôme
Published: March 2022

Urinary stones are a frequent situation, leading to high morbidity and health care costs. As a preventable disease, many diet modifications and sometimes pharmacologic interventions can avoid recurrence. The analysis of the stone is a cornerstone of the diagnosis, but is not made frequently, mainly because of practical considerations for the patients. There is no easy to use device. We tried a new medical device, Calculstop°, to catch the stone and keep it safe to the laboratory. We conducted a prospective study in 20 patients, showing 8 times more catching of the stone in recurrent cases. All patients who had catched the stone could have an analysis. The device also facilitated urinary pH measurement. We conclude that the device has been useful to help diagnosis and prevent recurrent stone.
Enhanced recovery after surgery (ERAS) program for elderly patients with anterior cervical discectomy and fusion (ACDF)
Authors: WANG QIANG , WANG PENG , KONG CHAO , TENG ZE , ZHANG SITAO , WANG SHUAIKANG , CUI PENG , SUN WENZHI , ZHAO GUOGUANG , LU SHIBAO
Published: March 2022

Background: Enhanced recovery after surgery (ERAS) is currently widely used in in many surgical specialties, but it is still lack of concerning the cervical ERAS program for elderly patients (>60 years old). We aimed to determine whether our ERASprogram significantly improved satisfaction and outcomes in elderly patients (>60 years old) with anterior cervical discectomy and fusion (ACDF). Methods: The study enrolled patients if they were over the age of 60 years old underwent under four levels ACDF. Data including demographic, comorbidity and surgical information were collected. We also evaluated ERAS process compliance, primary outcome, surgical complication and length of stay (LOS).Results: There were 135 patients in the ERAS group and 122 patients in the non-ERAS group were included. A comparison of the demographic data revealed that there were no statistically significant intergroup differences observed between the group. Overall, ERAS pathway compliance was 91.9%. There were no significant differences in the fusion levels、operative time、intraoperative blood loss、postoperative VAS score and complications between the ERAS and non-ERAS groups. In addition, there was no significant difference in readmission and mortality at 30-day follow-up between the two groups. However, we observed a statistically significant decrease in the LOS in the ERAS group (8.68±2.34 of ERAS group versus 10.43±4.05 in non-ERAS group, p=0.013). Conclusions: This report describes the first ERAS protocol used in elderly patients with ACDF. Our ERAS program is safe and associated with incremental benefits in respect to LOS in elderly patients with ACDF
Determinants of metabolic syndrome among type two diabetic patients following diabetic clinic of Arba Minch General hospital, southern Ethiopia- a case-control study
Authors: Abebe Getachew , Fikadu Teshale , Hailu Tadiwos , Temesgen Rodas
Published: March 2022

Purpose: Metabolic syndrome is a global public health issue that raises the risk of cardiovascular disease and early death. Globally, 70–80% of diabetic patient develop metabolic syndrome Comprehensive knowledge about risk factors for metabolic syndrome are essential to decrease the risk of cardiovascular diseases and improve the quality of life for diabetic patient. Thus, this study aims to determine predictors of metabolic syndrome among type two diabetic patients. This study aims to identify determinants of metabolic syndrome among type two diabetic patients.Methods: Facility-based unmatched case-control study was conducted among 204 systematically selected participants using a pre-tested, interviewer-administered questionnaire. Bivariate and multivariable logistic regression analyses were employed to identify determinants of metabolic syndrome using STAT version 16. Result: The probability of being female was 3.4 times higher among cases than controls as compared to being male [AOR=3.35, 95% CI (1.28, 8.73)]. The odds of being a rural dweller were 2 times higher among cases than controls as compared to rural dwellers [AOR = 3.10, 95% CI (1.27, 7.624)]. The likelihood being government employment was 4.4 times higher among cases than controls as compared to self-employed [AOR= 4.39, 95% CI ((1.28, 14.97)]. The odds of being obese were 2.7 times higher among cases than controls as compared to normal body mass index [AOR= 2.72, 95% CI ((1.03, 7.17)].Conclusion: -This study showed that sex, residence, occupation, and body mass index were found to be determinants of metabolic syndrome. Thus, concerned organizations and health professionals should focus on these factors in their efforts to reduce the risk of cardiovascular disease among diabetics.
Human languages trade off complexity against efficiency
Authors: Koplenig Alexander , Wolfer Sascha , Meyer Peter
Published: March 2022

One of the fundamental questions about human language is whether all languages are equally complex. To answer this long-standing question, we conduct a large scale quantitative cross-linguistic analysis of written language by training a language model on more than 6,500 different documents as represented in 41 multilingual text collections consisting of ~3.5 billion words or ~9.0 billion characters and covering 2,069 different languages that are spoken as a native language by more than 90% of the world population or ~46% of all languages that have a standardized written representation. Statistically inferring the entropy of each language-model as an index of (un)predictability/complexity allows us to refute the equi-complexity hypothesis, but also unveils a previously undocumented complexity-efficiency trade-off: high entropy languages are information-theoretically more efficient because they tend to need fewer symbols to encode messages. Our findings additionally contribute to debates about language evolution/diversity by showing that this trade-off is partly shaped by the social environment in which languages are being used.
Pure Arterial Malformation of the Left Middle Cerebral Artery: A Case Report
Authors: Fu Nian-xia , Song Jian-xun , Wu Ying-te , Lin Guo-hui
Published: March 2022

Background: Pure arterial malformations (PAMs) are rare intracranial vascular anomalies and involvement of the distal M3 segment of the middle cerebral artery are also uncommon. Diagnosis can become elusive when PAMs occur in atypical locations due to insufficient knowledge of the disease in spite of specific imaging characteristics. PAMs actually have a benign natural history and should be managed conservatively. We present a patient with a PAM of the left middle cerebral artery that was mistaken for an arteriovenous malformation and embolized.Case presentation: We report a case of pure arterial malformation of the left middle cerebral artery in a 41-year-old man with a two-day history of dizziness and limb convulsions. Preoperative MRI and DSA displayed the left middle cerebral artery was dilated, overlapping, and tortuous arteries forming a mass of arterial loops with a coil-like appearance. He was mistaken for an arteriovenous malformation and embolized.Conclusion: Our case highlights that intracranial vascular anomalies forming a mass of arterial loops lacking a venous component should be considered pure arterial malformations. Management and individual therapy are administrated to patient who are screened out PAMs.
Recurrent Infections Leading to DBS Removal but Reimplantation Achieving a Good Outcome: a Case Report
Authors: Li Tao , Wang Xiaoxi , Song Chunli , Ren Lu , Yin Xiaoxue , Pu Lanlan , Liang Zhanhua
Published: March 2022

Background: Deep brain stimulation (DBS) is an established treatment for patients with medical refractory Parkinson's disease (PD). DBS systems are implanted with the aim of providing permanent treatment, but infections, several early and late hardware related complications, suboptimal outcomes ,which might require revision operations with partial or even complete hardware removal. Here we described a surgical procedure with complete implants removal due to infections but reimplantation of a new DBS system achieved a good outcome in a patient with PD for over 20 years. Case presentation: A 70-year-old male with idiopathic PD for 22 years who underwent bilateral subthalamic nucleus (STN) DBS surgery with a non-rechargeable implantable pulse generator (IPG) when he was diagnosed PD for 8 years. His past history included hypertension and type 2 diabetes mellitus (DM). He underwent IPG replacement surgery in his 4th and 9th year after his initial DBS implantation. Four years after his latest IPG replacement surgery, he developed recurrent skin erosion around the DBS system. He underwent a total of four local incisions debridements (including two times of dissociated flap transplantation) and several sessions of antibiotic therapy before the final removal of the hardware. Fortunately after completion of antibiotic treatment, he underwent implantation of a new DBS system nine months later. No further complications appeared at the ninth months follow-up after reimplantation. The patient's symptoms had improved to a great extent, and he could take care of himself and his quality of life had improved significantly, which met the needs of the patient and his family.Conclusions: Infection is one of the most serious and difficult complications to manage after DBS implantation. Treatment of this complication can take a long time and lead to additional hospitalization, surgery and partial or total removal of the DBS system. However as long as the indications are met in any case, the reimplantation procedure can be reconsidered later, despite having had an infection and the electrode being removed.
TUCAN: A molecular identifier and descriptor applicable to the whole periodic table from hydrogen to oganesson
Authors: Brammer Jan C. , Blanke Gerd , Kellner Claudia , Hoffmann Alexander , Herres-Pawlis Sonja , Schatzschneider Ulrich
Published: March 2022

TUCAN is a canonicalization and serialization algorithm that is independent of domain-specific concepts of structure and bonding. Beyond the atomic number, all invariants used in the partitioning of a molecule are exclusively derived from the molecular topology and therefore make the algorithm also applicable to non-chemical graphs. In particular, the use of "fundamental" (chordless) cycles introduces an invariant of high discriminatory power which enables canonicalization of "difficult" graphs for which the popular Morgan algorithm fails. Extensive benchmarking is reported on a manually curated test set of molecules as well as a library of non-chemical graphs. In addition to the new canonicalization algorithm, the serialization procedure generates a unique "tuple-style" output which is fully bidirectional, allowing the TUCAN string to serve as both identifier and descriptor. Use of the Python NetworkX graph library facilitated a compact and easily extensible implementation.
Rehabilitation interventions for depression symptoms among cancer patients in Palestine: Literature review study.
Authors: Battat Maher , Marie Mohammad
Published: March 2022

Background Depression enhances disease burden in cancer patients, psychological interventions and rehabilitation of depression are required as a part of palliative care for cancer patients to improve the quality of life and mental healthThe aim of the study to review the literature about depression treatments and rehabilitation interventions among cancer patients in PalestineMethod: Review articles used electronic databases PubMed, Science Direct, Research Gate and Google Scholar to search for materials for the literature review study.Results: twenty three articles reviewed five of them from Arab and Islamic countries, and five articles from Palestine. Overall depression rehabilitation interventions for cancer patients are defined on two themes includes pharmacological interventions, and non-pharmacological interventions used that reduce depression symptoms and improve mental health among cancer patients. Depression rehabilitation interventions among cancer patients in Palestine are limited to palliative care perspective includes psychosocial support, cancer patient symptoms management, and family education. Conclusion: Depression symptoms treatments and rehabilitation interventions in Palestine are limited to non-pharmacological interventions from the perspective of palliative care for cancer patients including psychosocial interventions, besides cancer patient’s symptoms management affects mental health positively and depression recovery. Palliative care including depression symptoms rehabilitations in Palestine needs improvement. Israeli occupation is the main cause of limited rehabilitation and treatment interventions for Palestinian cancer patients.
LCK and its related molecules as potential biomarkers in rheumatoid arthritis
Authors: Chen Xuemeng , Xie Li , Jiang Yi , Zhang Ronghua , Wu Wei
Published: March 2022

Background
Rheumatoid arthritis (RA) is a type of systemic immune disease characterized by chronic inflammatory disease of the joints. However, the etiology and underlying molecular events of RA are unclear. Here, we applied bioinformatics analysis to identify the potential biomarkers involved in RA.
Methods
The three microarray datasets (GSE1919、GSE10500 and GSE55457) were downloaded from the Gene Expression Omnibus (GEO) database. We used the R software screen the differentially expressed genes (DEGs). These DEGs shared by the three microarray datasets were further identified. Next, we carried out functional enrichment analysis using the Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG). Then, the hub genes with a relatively high number of connections to other DEGs, were identified by Cytoscape. Other bioinformatics methods are also performed, including protein–protein interaction (PPI) network analysis and construction of miRNA–hub gene networks and transcription factors (TF)–hub gene networks.
Results
A total of 115 overlapping DEGs were identified in this study. Subsequently, we constructed a PPI network encoded by these DEGs and identified 10 genes closely associated with RA – LCK, GZMA, GZMB, CD2, LAG3, IL-15, TNFRSF4, CD247, CCR5, and CCR7. Furthermore, in the miRNA–hub gene networks, we screened out has-miR-146a-5p, which is the miRNA controlling the largest number of hub genes. Finally, we found some transcription factors that closely interact with hub genes, such as FOXC1, GATA2, YY1, RUNX2, SREBF1, CEBPB, and NFIC.
Conclusions
In summary, bioinformatics analyses were used to identify DEGs to find potential biomarkers that may be associated with RA. This study successfully predicted that LCK, FOXC1 and has-mir-146a-5p can be used as potential biomarkers of RA. Our study may have potential implications for future prediction of disease progression in symptomatic RA patients, and has important significance for the pathogenesis and targeted therapy of RA.
Transcriptome and SARS-CoV-2 biological network directed analysis for better therapeutic development
Authors: Sharma Om Prakash , Sharma Ruchika , Chandil Vinay
Published: March 2022

Background
It has been almost 2 years since the first SARS-CoV-2 virus was first reported in the city of Wuhan. So far, 8 drugs are approved against Covid-19 by FDA, however, an active drug against multi-mutational Covid-19 is still missing. In this present study, we aim to identify the most crucial and highly correlated protein targets from the publicly available transcriptomics datasets.
Methods
Transcriptomics datasets were retrieved from Geo Omnibus (GEO). We use relevant datasets to identify the most significant and differentially expressed genes and integrated them into a Research graph called CovInt (a network of Covid-19) that includes all biological molecules associated in the network with their directionalities collected from publicly available and patient-derived multi-omics datasets from millions of unstructured and structured datasets such as publications, patents, grants, preclinical and clinical reports. CovInt utilizes powerful traversal, clustering and centrality algorithms to identify key connections in the pathophysiology of the disease and its treatments.
Results
Leveraging 3M + connections, important interactions among key 42 drugs, 962 biological processes and molecular functions, 926 pathways, 897 phenotypes, 7103 proteins, 61 tissues were identified. This narrowed interactome was explored further using PageRank, lovain detection & strongly connected components (SSC) algorithms. In our analysis 63, strongly connected communities were identified which gives us an understanding of hidden underlying mechanisms. We further explored this network to identify and triangulate the key proteins, metabolic pathways and associated risk factors that can regulate moderate to severe Covid-19 infections.
Conclusions
Our study suggests that CREB3L1, SOX2, UBR4, FLNC, ITPA, DLG3, ING4, TECR, NADH, SMAD, HUWE1, DDX17, CREBBP, RELA, HPSE, TRIM33, TNFSF13B are the key regulator proteins and involved in ER-stress, cytokine signaling, T-Cell activation, Activation of NLRP3 Inflammation by SARS-CoV-2, JAK-STAT, IL-4, IL-13 pathways, MAPK signaling pathways, Activation of NMDA receptor & postsynaptic events and TGF-β signaling pathways.
Comparison of Aurolab Aqueous Drainage Implant with Ahmed Glaucoma Valve for refractory glaucoma: a meta-analysis
Authors: Hong Mingsheng , Peng Yaling , Lai Yuan , Hong Chaoyang
Published: March 2022

Background: The purpose of this study was to compare the efficacy and safety of the Aurolab aqueous drainage implant（AADI）and the Ahmed glaucoma valve(AGV) for the treatment of refractory glaucoma. Methods: We comprehensively searched four databases, including PubMed, EMBASE, Web of Science, and the Cochrane Library databases, selecting the relevant studies. The continuous variables, namely, intraocular pressure reduction (IOPR) and a reduction in antiglaucoma medication (AGMR), were pooled by the weighted mean differences (WMDs), and the dichotomous outcomes, including success rates and complications were pooled by the odds ratio (ORs). Results: A total of 825 eyes from 820 patients from six studies were included. The WMDs of the IOPR between the AADI and the AGV implant were 0.58 (95 % CI:0.07 to 1.09) at 3 months, 0.44 (95 % CI: 0.11 to 0.77) at 6 months, 2.20 (95 % CI: 0.63 to 3.77) at 12 months, and 3.24 (95 % CI: 1.73 to 4.75) at follow-up endpoint. Significant difference was detected between the two groups at any point in time. The WMDs of the AGMR between the AADI and the AGV implant were 0.87(95 % CI: 0.61 to 1.13) at 6 months, 1.04(95 % CI: 0.66 to 1.42) at 12 months, and 0.93 (95 % CI: 0.52 to 1.34) at the follow-up endpoint , the differences reached statistical significance at any point in time. The pooled ORs comparing the AADI with the AGV were 3.68(95 % CI: 2.58 to 5.25) for the complete success rate and 1.72(95 % CI: 1.24 to 2.39) for qualified success rate, significant difference was detected between the two groups. There were no significant differences between the AADI the AGV implant on the rates of adverse events. Conclusions: The AADI is more effective in both its surgical success rate and reducing IOP and AGM. And the two implants may have comparable incidences of adverse events.
Influence of receptor status and proliferation index in skeletal metastases of breast carcinoma on pathological fracture occurrence
Authors: Rajkovic Stanislav , Simic Ljubica , Djuricic Goran , Dundjerovic Dusko , Miceta Lazar , Milicic Biljana , Sopta Jelena
Published: March 2022

Purpose. Bones affected with metastatic breast carcinoma are prone to pathological fracture, impairing quality of life and survival rate. This study examined estrogen, progesterone, and HER2 receptors status, and Ki-67 index in skeletal metastases of breast carcinoma and their potential influence on pathological fracture occurrence.Methods. The study included 152 samples of skeletal metastasis of breast carcinoma, each obtained from an individual patient. Allred’s score was used for immunohistochemical interpretation. Clinical and radiological data were gathered from each patient`s history of the disease.Results. Femur stood out as an independent risk factor – it had a nine times higher chance for pathological fracture than other bones. Estrogen receptors, HER2, and Ki-67 status had no statistical significance for pathological fracture occurrence. Progesterone receptors showed significance for fracture development. The probability of fracture in progesterone receptor positive metastases was 68,1%, risk increasing with the rise of positive cells percentage, regardless of the expression intensity.Conclusion. Receptor status is important for skeletal metastases of breast carcinoma and can be used in clinical decision-making for systemic therapy and surgical treatment in fracture prevention.
The role of irradiance in controlling coralline algal calcification
Authors: Krieger Erik C. , Nelson Wendy A. , Grand Johan , Ru Eric Le , Bury Sarah J. , Cossais Amelie , Davy Simon K. , Cornwall Christopher E.
Published: March 2022

Coralline algae are an essential element of benthic ecosystems throughout the ocean’s photic zone. Yet, the role of light in shaping the physiology of coralline algae from cold-water, low-light habitats is poorly understood. Here, we assess the calcification physiology of five cool-temperate coralline algae in response to different irradiances over three months. We show that in contrast to current models focused on warmer water species, previously observed enhancement of calcification rates by photosynthesis is largely limited to lower irradiances, and that the removal of CO2 from the calcifying fluid (CF) is not the underlying mechanism of this enhancement. Instead, this likely occurs via two processes: 1) increased ion pumping rates to elevate the calcium carbonate saturation state in the CF; and 2) a higher daytime pH in the diffusion boundary layer that raises pHCF. However, as irradiance increases, ion pumping becomes increasingly saturated limiting further enhancements. Our results also suggest the existence of two calcification strategies in coralline algae and indicate that magnesium incorporation is determined by the internal magnesium to calcium ratio [Mg]CF/[Ca]CF. This study adds to our mechanistic understanding of calcification in coralline and fills in much needed knowledge about the role of light in controlling their physiology.
Peningkatan Hasil Bisnis Mochi Mitra (Mochi 3R) Dengan Melakukan Sub-Branding
Authors:   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Utomo Alvin , Bella Annastasia ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Ivan Narjosusilo David ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Loekmanhadi Gracesella ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Changgrawinata Julius ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Bustamin Stephanie ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Puspo Kuntjoro Antonius ,   Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: March 2022

Community Development is one of the best program of Prasetiya Mulya University in collaboration with various small businesses in remote areas of Cianjur and Cipanas. We had the opportunity to help Ms. Wiwi's mochi business in Cianjur. Mochi production by the community, especially Taman Jaya Dua Village, Gadog Village, Pacet District, Cianjur Regency, has high potential to be developed both in terms of quantity and quality. Many processes must be passed as the time goes by to help develop partners' mochi businesses, including increasing standardization and sub-branding of mochi styles, compiling production SOPs, using safe preservatives, making online marketing media, adding competent workforce, and monitoring business financial performance independent. Our results are very satisfying. Ms. Wiwi as the business owner is also very happy and open with the input we provide. The results we get from Community Service activities are very satisfying as well. The income earned by Ms. Wiwi has also improved in line with the development of Mochi Gaya.
A IMPORTÂNCIA DE UMA MARCA COLETIVA NA CONSTRUÇÃO DE TERRITÓRIOS
Authors: Turnes Valério , Sampaio Carlos Alberto Cioce , Sautier Denis , Guzzatti Thaise Costa
Published: March 2022

Objetiva-se avaliar o processo de construção da Acolhida na Colônia e a adoção, por ela, da estratégia “Sinais Distintivos” enquanto contribuição e consolidação do território das Encostas da Serra Geral, situado no Sudeste do estado de Santa Catarina, no Sul do Brasil, através do fortalecimento de alguns atributos territoriais (Identidade territorial, pertencimento e capital social). Foram realizados revisão bibliográfica, levantamento e análise de trabalhos acadêmicos e de documentos administrativos e coleta de dados de campo. Conclui-se que as estratégias utilizadas para implantar o agroturismo, as ações da Associação de Agroturismo e a efetividade de sua marca são elementos fundamentais para a construção do território, sobretudo pela sua contribuição para o fortalecimento do capital social, do sentimento de pertencimento e do reconhecimento da identidade territorial.
JUSTIÇA AMBIENTAL E VULNERABILIDADES SOCIOESPACIAIS
Authors: Muniz Miranda Hoffart Graziele , Terezinha Antonello Ideni
Published: March 2022

O setor de vigilância socioassistencial busca identificar e prevenir, por meio de indicadores, diagnósticos e estudos, situações de vulnerabilidades nos territórios. Porém, ao focar em questões vinculadas à pobreza, à privação de bens e direitos e à fragilização de vínculos familiares e comunitários, usualmente não engloba as injustiças ambientais que atingem desproporcionalmente os espaços de vivência dos grupos e das comunidades marginalizadas. Este artigo discute, por meio de revisão bibliográfica, como a compreensão e a mensuração das injustiças ambientais podem colaborar para as funções da vigilância socioassistencial e, de modo mais amplo, contribuir para a gestão das políticas sociais municipais. São sugeridos modos de aliar metodologias quantitativas e qualitativas como forma de contribuir para os trabalhos da vigilância socioassistencial e a promoção de políticas públicas.
Regional Brain Oxygen Saturation: There is also Life Beyond the Brain
Authors: J.L. Guerrero Orriach , A. Ramirez Fernandez
Published: March 2022

Some procedures, such as cardiovascular surgery, may compromise brain perfusion and require careful
management to preserve the integrity of the central nervous system. In this setting, regional cerebral oxygen
saturation [rSO2] emerges as an alternative, minimally invasive, monitoring system. The mechanism by which
regional oxygen is measured is based on the refraction and absorption of a signal with a specific wavelength.
Diagnostic and therapeutic algorithms for these settings would allow for a more rational use of goal-directed
therapies that reduce morbidity and mortality in these patients.
An Arduino System for Collecting the Garbage in A Segregated Manner
Authors: Mathur Sandeep
Published: March 2022

Garbage collection and segregation are among the biggest problems in today's world
across the globe. This work proposed a System that helps clean waste and eases people in daily life.
This system, proposed by Swachh Bharat Abhiyan, is an intelligent waste segregator bin embedded
with many applications. The system relies on an "Ultrasonic sensor, Calorimetric sensor, LED, Arduino,
programming language and some hardware used." The invention is quite innovative and advantageous.
A gist of the system mainly uses two divided sections for the segregation of bio and
non-biodegradable wastes. Arduino has been used to save the coding of the system. Hence, the system
helps us maintain and reduce garbage levels and can be proven a blessing in the waste management.
The patent office of India has patented the proposed innovation, application number
202111006039, 12th Feb 2021, and copyright has been granted from the copyright office, India, on
the design of the proposal having registration number L-104358/2021 dated 10th June 2021.
Molecular Marker Analysis of Genetic Diversity in Maize: A Review
Authors:   Department of Genetics and Plant Breeding, Chandra Shekhar Azad University of Agriculture and Technology, Kanpur, India, Kumar Anand , Longmei Ningthai ,   ICAR-Indian Institute of Maize Research, Ludhiana, India, Kumar Pardeep ,   ICAR-Indian Institute of Maize Research, Ludhiana, India, Kaushik Prashant ,   Kikugawa Research Station, Yokohama Ueki, 2265, Kamo, Kikugawa City, Shizuoka 439-0031, Japan,   Instituto de Conservación y Mejora de la Agrodiversidad Valenciana, Universitat Politècnica de València, Valencia, Spain
Published: March 2022

Maize is consumed as a food and used as an industrial product in the form of starch, pharmaceuticals, alcoholic beverages, oil, cosmetics, and textiles. In ancient times, landraces were more popular due to the presence of high genetic variability, resistance to biotic and abiotic factors, and the heterogeneous nature of maize; however, it has been replaced by improved and uniform cultivars with a higher yield. Modern maize has more homogeneity that enhances its vulnerability to biotic and abiotic stresses. Thus, we need to study the diversity in maize to successfully use its characteristics. Several markers such as morphological, biochemical, and DNA-based markers/molecular markers are utilized to study the germplasm diversity. Although extensively used, morphological and biochemical markers were highly sensitive to the environment because of which, these are being replaced by molecular markers. In the current era of molecular markers, DNA markers play an important role in identifying diverse germplasms because of high precision and accuracy. In this review, we focused on the types of markers utilized to accelerate the knowledge of maize genetic diversity and the prospect of genetic diversity.
Virtual Prehabilitation in Patients With Cancer Undergoing Surgery During the COVID-19 Pandemic: Protocol for a Prospective Feasibility Study
Authors: Lambert Genevieve , Drummond Kenneth , Tahasildar Bhagya , Carli Francesco
Published: March 2022

Background

Since the beginning of the COVID-19 pandemic, preoperative care, also termed prehabilitation, has become increasingly relevant due to the decreasing functional and psychosocial health of patients with cancer, which is a result of the pandemic restrictions. Concurrently, access to telehealth has improved; telehealth comprises all remote care delivery facilitated by information technologies (ie, virtually).

Objective

The aim of this protocol is to describe the rationale and methodology for a major trial investigating the feasibility and safety of multimodal virtual prehabilitation services (ie, teleprehabilitation).

Methods

This single-arm feasibility trial aims to recruit 100 patients with cancer to receive teleprehabilitation throughout their preoperative period. The inclusion criteria are as follows: (1) 18 years of age or older, (2) scheduled for elective cancer surgery and referred by a surgeon, (3) medically cleared by the referring physician to engage in physical activity, and (4) have a good comprehension of the English or French language. Feasibility will be assessed by documenting recruitment, adherence, and retention rates, in addition to patients’ motives for not participating in the trial, low participation, or discontinuation. The secondary outcome of safety will be assessed by reporting program-related adverse events.

Results

The Montreal General Hospital Foundation funded the project in August 2020. The protocol was then approved by the Research Ethics Board of the McGill University Health Centre in January 2021 (ID No. 2021-6730). The first patient was recruited in March 2021, and recruitment is expected to end in September 2022. As of March 2022, 36 patients have been recruited, including 24 who have completed their participation. No adverse events have been reported. Data collection is expected to conclude in November 2022. Data analysis will be performed, and the results will be published by the beginning of 2023.

Conclusions

This trial will provide guidance on the use of telehealth in the administration of prehabilitation services. The trial will provide a large amount of information that will respond to gaps in the literature, as there are minimal reports on the use of telehealth rehabilitation and prehabilitation services among elderly populations and in acute contexts, such as the preoperative period.

Trial Registration

ClinicalTrials.gov NCT0479956; https://clinicaltrials.gov/ct2/show/NCT04799561

International Registered Report Identifier (IRRID)

DERR1-10.2196/29936
Exploring Human-Data Interaction in Clinical Decision-making Using Scenarios: Co-design Study
Authors: Tendedez Helena , Ferrario Maria-Angela , McNaney Roisin , Gradinar Adrian
Published: March 2022

Background

When caring for patients with chronic conditions such as chronic obstructive pulmonary disease (COPD), health care professionals (HCPs) rely on multiple data sources to make decisions. Collating and visualizing these data, for example, on clinical dashboards, holds the potential to support timely and informed decision-making. Most studies on data-supported decision-making (DSDM) technologies for health care have focused on their technical feasibility or quantitative effectiveness. Although these studies are an important contribution to the literature, they do not further our limited understanding of how HCPs engage with these technologies and how they can be designed to support specific contexts of use. To advance our knowledge in this area, we must work with HCPs to explore this space and the real-world complexities of health care work and service structures.

Objective

This study aimed to qualitatively explore how DSDM technologies could support HCPs in their decision-making regarding COPD care. We created a scenario-based research tool called Respire, which visualizes HCPs’ data needs about their patients with COPD and services. We used Respire with HCPs to uncover rich and nuanced findings about human-data interaction in this context, focusing on the real-world challenges that HCPs face when carrying out their work and making decisions.

Methods

We engaged 9 respiratory HCPs from 2 collaborating health care organizations to design Respire. We then used Respire as a tool to investigate human-data interaction in the context of decision-making about COPD care. The study followed a co-design approach that had 3 stages and spanned 2 years. The first stage involved 5 workshops with HCPs to identify data interaction scenarios that would support their work. The second stage involved creating Respire, an interactive scenario-based web app that visualizes HCPs’ data needs, incorporating feedback from HCPs. The final stage involved 11 one-to-one sessions with HCPs to use Respire, focusing on how they envisaged that it could support their work and decisions about care.

Results

We found that HCPs trust data differently depending on where it came from and who recorded it, sporadic and subjective data generated by patients have value but create challenges for decision-making, and HCPs require support in interpreting and responding to new data and its use cases.

Conclusions

Our study uncovered important lessons for the design of DSDM technologies to support health care contexts. We show that although DSDM technologies have the potential to support patient care and health care delivery, important sociotechnical and human-data interaction challenges influence the design and deployment of these technologies. Exploring these considerations during the design process can ensure that DSDM technologies are designed with a holistic view of how decision-making and engagement with data occur in health care contexts.
Locating Youth Exposed to Parental Justice Involvement in the Electronic Health Record: Development of a Natural Language Processing Model
Authors: Boch Samantha , Hussain Syed-Amad , Bambach Sven , DeShetler Cameron , Chisolm Deena , Linwood Simon
Published: March 2022

Background

Parental justice involvement (eg, prison, jail, parole, or probation) is an unfortunately common and disruptive household adversity for many US youths, disproportionately affecting families of color and rural families. Data on this adversity has not been captured routinely in pediatric health care settings, and if it is, it is not discrete nor able to be readily analyzed for purposes of research.

Objective

In this study, we outline our process training a state-of-the-art natural language processing model using unstructured clinician notes of one large pediatric health system to identify patients who have experienced a justice-involved parent.

Methods

Using the electronic health record database of a large Midwestern pediatric hospital-based institution from 2011-2019, we located clinician notes (of any type and written by any type of provider) that were likely to contain such evidence of family justice involvement via a justice-keyword search (eg, prison and jail). To train and validate the model, we used a labeled data set of 7500 clinician notes identifying whether the patient was ever exposed to parental justice involvement. We calculated the precision and recall of the model and compared those rates to the keyword search.

Results

The development of the machine learning model increased the precision (positive predictive value) of locating children affected by parental justice involvement in the electronic health record from 61% (a simple keyword search) to 92%.

Conclusions

The use of machine learning may be a feasible approach to addressing the gaps in our understanding of the health and health services of underrepresented youth who encounter childhood adversities not routinely captured—particularly for children of justice-involved parents.
Prediction of Chronic Obstructive Pulmonary Disease Exacerbation Events by Using Patient Self-reported Data in a Digital Health App: Statistical Evaluation and Machine Learning Approach (Preprint)
Authors: Chmiel Francis P , Burns Dan K , Pickering John Brian , Blythin Alison , Wilkinson Thomas MA , Boniface Michael J
Published: March 2022

BACKGROUND

Self-reporting digital apps provide a way of remotely monitoring and managing patients with chronic conditions in the community. Leveraging the data collected by these apps in prognostic models could provide increased personalization of care and reduce the burden of care for people who live with chronic conditions. This study evaluated the predictive ability of prognostic models for the prediction of acute exacerbation events in people with chronic obstructive pulmonary disease by using data self-reported to a digital health app.

OBJECTIVE

The aim of this study was to evaluate if data self-reported to a digital health app can be used to predict acute exacerbation events in the near future.

METHODS

This is a retrospective study evaluating the use of symptom and chronic obstructive pulmonary disease assessment test data self-reported to a digital health app (myCOPD) in predicting acute exacerbation events. We include data from 2374 patients who made 68,139 self-reports. We evaluated the degree to which the different variables self-reported to the app are predictive of exacerbation events and developed both heuristic and machine learning models to predict whether the patient will report an exacerbation event within 3 days of self-reporting to the app. The model’s predictive ability was evaluated based on self-reports from an independent set of patients.

RESULTS

Users self-reported symptoms, and standard chronic obstructive pulmonary disease assessment tests displayed correlation with future exacerbation events. Both a baseline model (area under the receiver operating characteristic curve [AUROC] 0.655, 95% CI 0.689-0.676) and a machine learning model (AUROC 0.727, 95% CI 0.720-0.735) showed moderate ability in predicting exacerbation events, occurring within 3 days of a given self-report. Although the baseline model obtained a fixed sensitivity and specificity of 0.551 (95% CI 0.508-0.596) and 0.759 (95% CI 0.752-0.767) respectively, the sensitivity and specificity of the machine learning model can be tuned by dichotomizing the continuous predictions it provides with different thresholds.

CONCLUSIONS

Data self-reported to health care apps designed to remotely monitor patients with chronic obstructive pulmonary disease can be used to predict acute exacerbation events with moderate performance. This could increase personalization of care by allowing preemptive action to be taken to mitigate the risk of future exacerbation events.
Demographic and Psychosocial Characteristics Associated With Use of a Prostate Cancer Survivorship Website: Implications From a Multisite Randomized Controlled Trial (Preprint)
Authors: Marziliano Allison , Diefenbach Michael A , Hudson Shawna V , Tagai Erin K , Handorf Elizabeth A , Bator Alicja , Miller Suzanne M
Published: March 2022

BACKGROUND

Many prostate cancer (PC) survivors experience disease and treatment-related symptomatology in both the physical and psychosocial domains. Although the benefits and barriers to using web-based resources for cancer patients are well-documented, less research has focused on the personal characteristics important for efficient tailoring and targeting of information that are associated with usage.

OBJECTIVE

We used the Cognitive-Social Health Information Processing (C-SHIP) framework to guide our exploration of personal characteristics associated with use of PROGRESS, an informational PC survivorship website that addresses physical, emotional, interpersonal, and practical concerns relevant for PC survivors.

METHODS

PC survivors (N=217) were randomized to the intervention arm (PROGRESS) of a randomized controlled trial. Of those randomized to the intervention arm, 84 used PROGRESS, and 133 did not use PROGRESS. Multivariable analyses evaluated demographic and psychosocial characteristics (eg, style of coping, health literacy, self-efficacy, affective states of depression, anxiety, and fatigue) associated with website use.

RESULTS

A larger proportion of non-Hispanic White (68/160, 42.5%), compared with non-Hispanic Black (9/40, 23%), participants used PROGRESS (P<.001). Further, PROGRESS users were older in age (P<.001), had a monitoring style of coping (P=.01), and were less depressed (P=.004), anxious (P=.02), and fatigued (P<.001) than nonusers. Education, income, health literacy, blunting style of coping, self-efficacy, and treatment type (radiation therapy or surgery) were not significantly related to use. On multivariable analyses, race (OR 0.28, P<.001), age (OR 1.05, P<.001), monitoring style of coping (OR 1.27, P=.02), and overall mood (OR 0.98, P<.001) remained significant.

CONCLUSIONS

A combination of monitoring and low levels of negative affect were associated with website use. Additionally, users were older, non-Hispanic White survivors. To ensure that important survivorship-relevant information reaches users, future efforts need to focus on enhancing patient engagement.

CLINICALTRIAL

ClinicalTrials.gov NCT02224482; https://clinicaltrials.gov/ct2/show/NCT02224482