bluuebunny/crossref_metadata_2025 huggingface dataset:
UMA EXPERIÊNCIA DE INVESTIGAÇÃO E INTERVENÇÃO COMUNITÁRIA: INTERFACES ENTRE FORMAÇÃO, ATENÇÃO BÁSICA E SAÚDE MENTAL
Authors: Martins Torres Catarine , Da Silva Eidam de Lima Camila , Shigueki Suzuki Claudio , De Paula Santos Emalline , Zambenedetti Gustavo , Schinemann Vanderleia
Published: December 2020

Este artigo parte do desafio apresentado em um programa de mestrado, que consiste em fomentar uma formação que articule a pesquisa no âmbito comunitário, sob um viés interdisciplinar. Nesse sentido, relataremos uma experiência de aproximação com um contexto comunitário, com o objetivo de levantar demandas locais e construir um projeto de  intervenção. Uma Unidade de Saúde da Família foi escolhida como dispositivo comunitário para a realização do trabalho. Foram realizadas observações participantes do cotidiano da unidade. A experiência foi sistematizada em 3 movimentos: aproximação e levantamento de demandas; delimitação de uma problemática para a intervenção; construção e implementação de uma proposta de intervenção. Foi possível constituir um diagnóstico, destacando-se a saúde mental como um dos principais temas demandados pela equipe. Com base nisso, foi organizada uma oficina sobre saúde mental, com a participação da equipe da unidade, da coordenação de um serviço de referência em saúde mental e das mestrandas, propiciando um dispositivo de reflexão e aprendizagem. Percebeu-se a relevância do trabalho realizado para a sistematização de um modo de aproximação com a comunidade, sob viés participativo, propiciando uma articulação comunidade-universidade em que ambos se beneficiam.
Implementasi Metode Tamyiz Dalam Pembelajaran Baca Kitab Kuning
Authors: Wildan Khoirul
Published: December 2020

Abstrak
Penguasaan ilmu nahwu shorof yang memadai sangat dibutuhkan untuk dapat membaca dan menulis serta menterjemahkan kitab kuning, sedangkan nahwu shorof sedari dulu dianggap sulit untuk mengkonsep dan memahami teorinya dalam pembelajaran yang mudah. Karenanya, ketepatan sebuah metode bahasa arab sangat dibutuhkan. Metode Tamyiz merupakan metode yang praktis untuk pembelajaran terjemah Al-Qurâ€™an dan kitab kuning. Hizbul Kaafi merupakan salah satu lembaga kursus bahasa arab yang menerapakan metode Tamyiz dalam salah satu program pembelajarannya, padahal penerapan metode Tamyiz di sekolah dan di madrasah terbilang jarang. Tulisan ini mengunkap implentasi dan system evaluasi metode Tamyiz dalam pembelajaran baca kitab kuning di Hizbul Kaafi Pare Kediri. Penelitian ini berjenis penelitian lapangan dengan pendekatan analisis kualitatif deskriptif, menggunakan sumber primer dan sekunder, dengan tehnik observasi, wawancara, dan dokumentasi dalam prosedur pengumpulan datanya, sedangkan analisis datanya dilakukan dengan mereduksi, menyajikan, dan memverifikasi data. Uji keabsahan datanya menggunakan Uji Credibility dengan bentuk perpanjangan pengamatan, triangulasi, peningkatan kecermatan, analisis kasus negative, dan member check. Hasil penelitian, yaitu: (1) Pelaksanaan pembelajaran baca kitab kuning dengan metode Tamyiz, merupakan bentuk gabungan dari pembelajaran tradisional, metode pengajaran langsung, dan model pembelajaran Quantum yaitu sebuah model yang membiasakan belajar menyenangkan demi meningkatkan minat belajar sampai hasil belajar peserta secara menyeluruh. (2) Hasil penilaian observasi menunjukkan bahwa kegiatan pembelajaran tamyiz berjalan dengan baik dengan system evaluasi metode Tamyiz di Hizbul Kaafi menggunakan evaluasi sumatif dan formatif.
Kata Kunci: Metode Tamyiz, Pembelajaran Baca Kitab Kuning.
Estudos organizacionais pós-modernos: uma bibliometria no novo milênio
Authors: Oliveira Junior Marcelo , Pereira Ana Luiza Cordeiro , Sadocco Rafael Rodolfo Sartorelli , Souza Juliana de Oliveira Becheri , Teodoro Alberdan José da Silva
Published: December 2020

Neste artigo buscamos entender qual tem sido o escopo da produção científica sobre organizações na pós-modernidade. Para tal, recorremos a um estudo quantitativo (bibliometria), recuperando artigos científicos indexados à base de dados Web of Science, no período entre 2000 e 2018. Após a aplicação dos critérios de filtragem, selecionou-se 432 trabalhos, os quais foram analisados pelo software VOSviewer. Dentre os resultados, destaca-se a comportamento das produções cientificas sobre o tema no intervalo temporal, os periódicos e autores mais citados, bem como a sugestões para a realização de estudos futuros. Concluímos que os estudos organizacionais na pós-modernidade continuam atraindo muita atenção da academia, posto que no intervalo de tempo proposto, foi possível detectar nesse intervalo de tempo, um crescimento no número de publicações sobre o tema. Desse modo, supomos que esse número tende a crescer, abarcando cada vez mais novos temas, o que indica a possibilidade de que os estudos sobre as organizações na pós-modernidade sejam ainda mais explorados no futuro.
Promoção da segurança alimentar e nutricional em escolas de ensino médio em tempo integral: relato de experiência extensionista
Authors: Rabelo Claísa Andrea Freitas , Mendes Ana Erbênia Pereira , Holanda Luiz  Eduardo Oliveira , Souza Fernanda  Elaine Barros , Lima Daniel da Silva , Amaral Rafael  Queiroz Gurgel do , Bezerra José Arimatea Barros , Sousa Paulo Henrique Machado de
Published: December 2020

O presente trabalho tem como objetivo apresentar o relato de experiências de um projeto de extensão do Curso de Gastronomia da Universidade Federal do Ceará (UFC), realizado em cinco escolas de ensino médio em tempo integral da cidade de Fortaleza,  nos anos de 2017 a 2020, buscando criar ambiente de aprendizagem de educação alimentar e nutricional para o desenvolvimento de alimentação de qualidade e a construção de hábitos alimentares saudáveis e sustentáveis. O projeto foi realizado por discentes da UFC, coordenados por professores do Curso de Gastronomia que atuaram no planejamento, desenvolvimento e avaliação das atividades, instrumentos de pesquisa e produtos gerados. Os estudantes de ensino médio foram orientados quanto às práticas alimentares saudáveis, a análise do estado nutricional e dos hábitos alimentares desses estudantes e a implantação de horta escolar para o cultivo de hortaliças. As ações extensionistas do Curso de Gastronomia da UFC tem contribuído para a construção de conhecimentos e atitudes relacionadas a alimentação e sustentabilidade nos ambientes escolares, colaborando de forma ativa para a segurança alimentar e nutricional dos jovens assistidos. É uma iniciativa que precisa ser expandida haja vista que apesar da relevância da temática, atividades de Segurança Alimentar e Nutricional não ocorrem de forma efetiva na maioria das escolas integrando as práticas da produção do alimento com os cuidados sociais, ambientais e nutricionais, como é proporcionado ser vivenciado no referido projeto de extensão.
Realocação de silagens em propriedades rurais: uma abordagem sobre o estado da arte
Authors: Freitas Cássia Aparecida Soares , Anjos Albert José dos , Alves Wagner Sousa , Macêdo Alberto Jefferson da Silva , Coutinho Danielle Nascimento , Barcelos Mateus de Paula , Abreu Mateus José Inácio de , Conceição Manoel Wadson Lima da
Published: December 2020

A introdução de forragens conservadas na dieta animal é uma estratégia viável e de grande relevância, não somente nos períodos de escassez de forragem ofertada via pastejo, mas também, nos sistemas de produção onde o rebanho é confinado, e a base alimentar depende da utilização de alimentos conservados, que participam em níveis expressivos na composição da dieta. Entretanto, uma série de circunstâncias tais como condições climáticas, falta de maquinários e insucesso no planejamento forrageiro, podem tornar-se fator complicador para que a produção de silagem ocorra de maneira eficiente, assegurando a quantidade e qualidade demandada na propriedade. É justamente neste contexto, que a prática de realocação de silagem ou reensilagem surge como opção crescente no Brasil, visando atender as demandas mencionadas anteriormente, assim como fortalecer o mercado focado na comercialização de silagem entre fazendas. Com isso, o objetivo deste trabalho foi realizar uma revisão de literatura para abordar os aspectos inerentes à realocação de silagem dentro da propriedade rural. A metodologia empregada possui natureza qualitativa e cunho descritivo. Os resultados das pesquisas apontam possível impacto na qualidade de silagens realocadas, porém alguns deles podem existir em função da exposição e possível deterioração aeróbia da silagem, influenciando o consumo e desempenho animal. Os estudos têm demonstrado que esta é uma prática passível de realização, no entanto a eficiência ao longo de todo processo estará intimamente ligada à qualidade do produto final que será ofertado aos animais.
“Foi medo, não foi coragem”: iniquidades raciais na assistência obstétrica
Authors: Guimarães Juliana Cristina Nascimento , Rodrigues Andreza , Santos Aricele Ferreira dos
Published: December 2020

Trata-se de uma pesquisa descritiva, de abordagem compreensivista, que objetivou explorar a perspectiva de mulheres negras sobre as iniquidades raciais na assistência obstétrica e analisar as suas percepções acerca da assistência recebida durante a gestação, parto e pós-parto. Foram entrevistadas oito mulheres, no período de abril a setembro de 2019, através de entrevistas individuais, utilizando a técnica de entrevista narrativa aberta. Os dados foram analisados por meio da técnica da análise de conteúdo temático. As entrevistadas afirmam que desejam um parto respeitoso e de sua escolha, entretanto, relatam as experiências racistas vividas e estratégias utilizadas durante a gestação para fugir da violência obstétrica. Conclui-se que elas consideram o cenário da assistência obstétrica desigual e mais violento para as mulheres negras, e em seus processos de gestar e parir criam uma rota de fuga dessa violência, em busca de garantir um parto humanizado. Além disso, afirmam que a rede de apoio é fundamental para o protagonismo durante o parto e para a mulher negra essa rede também funciona como fator protetor diante da violência obstétrica.
Combinação do butafosfan associado a cianocobalamina no incremento da fertilidade em fêmeas zebuínas
Authors: Rodrigues Vanessa de Sousa , Vilches Júnior Mário Antônio , Souza Ana Beatriz Bezerra , Rodrigues Matheus Henrique Dias , Oliveira Rodolfo Olinto Rotoli Garcia , Fioravante Fernanda Carolina Rotta Cristino , Bussiman Fernando Oliveira , Nepomuceno Leandro Lopes , Garcia José Américo Soares , Ferreira Jorge Luís
Published: December 2020

O objetivo do presente estudo foi de avaliar o efeito da suplementação mineral vitamínica injetável de fósforo e vitamina B12 no desempenho reprodutivo de fêmeas bovinas da raça Nelore criadas no estado do Pará, submetidas ao protocolo de IATF. Foram utilizadas 170 vacas distribuídas em 2 tratamentos, sendo T1 (n=93) que recebeu 10 ml da suplementação injetável e T2 (n=77) que recebeu 10 ml de placebo, todos no D0 do protocolo de IATF. Todas as vacas receberam o mesmo protocolo de IATF no qual: D0 (implante intravaginal de P4 + 2 mg BE por via IM), D8 (0,5 mg PGF2α + 300 UI eCG + 1 mg CE todos por via IM e remoção do implante de P4), D10 (IATF) e D40 (Diagnóstico gestacional com ultrassom). Os dados foram tabulados em planilhas do programa Microsoft Excel e analisados no programa Statistical Analysis System [SAS] (2009) e submetidos análise de variância pelo 7 Proc GLMMIX. A taxa de prenhez no T1 foi 61,29% (57/93) e T2 com 45,45% (35/77) com diferença significativa (P<0,05). Dessa forma, a suplementação injetável supriu algumas carências de minerais dos animais e promoveu incremento na fertilidade de vacas submetidas a protocolo de IATF.
Ensino-aprendizagem de geografia em tempos de pandemia: relato e discussão sobre estratégias adotadas no Ensino Remoto Emergencial
Authors: Silva Paulo Eduardo Alves Borges da , Nunes Malena Silva
Published: December 2020

Este trabalho consiste em um relato de experiência da vivência profissional em lecionar o conteúdo da disciplina de Geografia para alunos do Ensino Técnico Integrado do Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais - campus Betim, diante do cenário emergencial de adoção de um ensino remoto emergencial, majoritariamente via Tecnologias Digitais de Informação e Comunicação (TDICs). São apresentados conceitos e teorias relacionados à educação, ao ensino, à relação ensino-aprendizagem que embasam discussões relacionadas às diferentes possibilidades de métodos de ensino e estilos de aprendizagem. Tal alicerce subsidia os exemplos apresentados, que foram distribuídos via Ambiente Virtual de Aprendizagem (AVA). Assim, o objetivo deste relato é apresentar e discutir as estratégias adotadas em aulas e atividades avaliativas. Observa-se que, dado o caráter excepcional do ano de 2020, de pandemia e ensino remoto, foi possível manter relações importantes, como a professor-aluno e a escola-aluno. Além disso, é possível afirmar que a variação nos métodos de ensino propiciou engajamento, interesse e envolvimento dos alunos, o que ficou evidenciado pela participação nas aulas síncronas e pelos comentários após o cumprimento de atividades. Dessa maneira, o que seria uma possibilidade emergencial para o contexto de ensino atual tornou-se uma ferramenta importante quando da retomada das atividades presenciais.
Gestão democrática e o Projeto Político Pedagógico: práticas e contradições de uma realidade escolar, em Goianésia do Pará/PA
Authors: Souza Lindomar Pereira de
Published: December 2020

A discussão que permeia sobre o entendimento de gestão democrática e a importância do Projeto Político Pedagógico da escola se faz necessário conhecer, uma vez que, muito se fala sobre tal projeto e pouco se sabe de sua relevância para escola contemporânea. A pesquisa teve como objeto de estudo "As causas da não participação efetiva dos diversos atores no desenvolvimento dos projetos planejados pela escola no decorrer do ano letivo", e como objetivos: investigar os fatores que têm ocasionado a não participação dos diversos atores na culminância dos projetos da escola desenvolvidos no percurso do ano letivo e detectar se a escola desenvolve uma gestão democrática nos moldes previstos pela legislação em vigor, Lei nº 9394/96. A pesquisa foi de abordagem qualitativa tendo como base teórica metodológica Teixeira e Thiollent já no aspecto teórico bibliográfico se sustentou em autores como: Dalmás, Libâneo, Paro, Veiga, Luck e outros que dialogam com o campo de estudo. A pesquisa apontou que existe na prática um jogo de contradição ao se tratar da participação dos professores na execução dos projetos, e que a ausência de um profissional tem implicações negativas sobre as questões pedagógicas de uma escola e a gestão escolar é marcada por um esforço na prática por uma postura democrática, pois são oportunizados todos os mecanismos de participação no sentido de garantir o envolvimento coletivo, não havendo uma centralização de poder, mesmo assim ainda existem lacunas quanto ao ato de gerir na perspectiva democrática.
Alcohol associated liver cirrhotics have higher mortality after index hospitalization: Long-term data of 5,138 patients
Authors: Jain Priyanka , Shasthry Saggere Muralikrishna , Choudhury Ashok Kumar , Maiwall Rakhi , Kumar Guresh , Bharadwaj Ankit , Arora Vinod , Vijayaraghavan Rajan , Jindal Ankur , Sharma Manoj Kumar , Bhatia Vikram , Sarin Shiv Kumar
Published: December 2020

Background/Aims: Liver cirrhosis is an important cause of morbidity and mortality globally. Every episode of decompensation and hospitalization reduces survival. We studied the clinical profile and long-term outcomes comparing alcohol-related cirrhosis (ALC) and non-ALC.
Methods: Cirrhosis patients at index hospitalisation (from January 2010 to June 2017), with ≥1 year follow-up were included.
Results: Five thousand and one hundred thirty-eight cirrhosis patients (age, 49.8±14.6 years; male, 79.5%; alcohol, 39.5%; Child-A:B:C, 11.7%:41.6%:46.8%) from their index hospitalization were analysed. The median time from diagnosis of cirrhosis to index hospitalization was 2 years (0.2–10). One thousand and seven hundred seven patients (33.2%) died within a year; 1,248 (24.3%) during index hospitalization. 59.5% (2,316/3,890) of the survivors, required at least one readmission, with additional mortality of 19.8% (459/2,316). ALC compared to non-ALC were more often (P<0.001) male (97.7% vs. 67.7%), younger (40–50 group, 36.2% vs. 20.2%; P<0.001) with higher liver related complications at baseline, (P<0.001 for each), sepsis: 20.3% vs. 14.9%; ascites: 82.2% vs. 65.9%; spontaneous bacterial peritonitis: 21.8% vs. 15.7%; hepatic encephalopathy: 41.0% vs. 25.0%; acute variceal bleeding: 32.0% vs. 23.7%; and acute kidney injury 30.5% vs. 19.6%. ALC patients had higher Child-Pugh (10.6±2.0 vs. 9.0±2.3), model for end-stage liver-disease scores (21.49±8.47 vs. 16.85±7.79), and higher mortality (42.3% vs. 27.3%, P<0.001) compared to non-ALC.
Conclusions: One-third of cirrhosis patients die in index hospitalization. 60% of the survivors require at least one rehospitalization within a year. ALC patients present with higher morbidity and mortality and at a younger age.
The cut-off value of transient elastography to the value of hepatic venous pressure gradient in alcoholic cirrhosis
Authors: Ryu Se Ri , Yoo Jeong-Ju , Kang Seong Hee , Jeong Soung Won , Kim Moon Young , Cho Young Kyu , Chang Young , Kim Sang Gyune , Jang Jae Young , Kim Young Seok , Baik Soon Koo , Kim Yong Jae , Park Su Yeon , Baymbajav Baigal
Published: December 2020

Background/Aims: The hepatic venous pressure gradient (HVPG) reflects portal hypertension, but its measurement is invasive. Transient elastography (TE) is a noninvasive method for evaluating liver stiffness (LS). We investigated the correlation between the value of LS, LS to platelet ratio (LPR), LS-spleen diameter-to-platelet ratio score (LSPS) and HVPG according to the etiology of cirrhosis, especially focused on alcoholic cirrhosis.Methods: Between January 2008 and March 2017, 556 patients who underwent HVPG and TE were consecutively enrolled. We evaluated LS, LPR, and LSPS according to the etiology of cirrhosis and analyzed their correlations with HVPG.Results: The LS value was higher in patients with alcoholic cirrhosis than viral cirrhosis based on the HVPG (43.5 vs. 32.0 kPa, P<0.001). There were no significant differences in the LPR or LSPS between alcoholic and viral cirrhosis groups, and the areas under the curves for the LPR and LSPS in subgroups according to HVPG levels were not superior to that for LS. In alcoholic cirrhosis, the LS cutoff value for predicting an HVPG ≥10 mmHg was 32.2 kPa with positive predictive value (PPV) of 94.5% and 36.6 kPa for HVPG ≥12 mmHg with PPV of 91.0%.Conclusions: The LS cutoff value should be determined separately for patients with alcoholic and viral cirrhosis. In alcoholic cirrhosis, the LS cutoff values were 32.2 and 36.6 kPa for predicting an HVPG ≥10 and ≥12 mmHg, respectively. However, there were no significant differences in the LPR or LSPS between alcoholic and viral cirrhosis groups.
Anti-fibrotic treatments for chronic liver diseases: The present and the future
Authors: Odagiri Naoshi , Matsubara Tsutomu , Sato-Matsubara Misako , Fujii Hideki , Enomoto Masaru , Kawada Norifumi
Published: December 2020

Liver fibrosis reflects tissue scarring in the liver due to the accumulation of excessive extracellular matrix in response to chronically persistent liver injury. Hepatocyte cell death can trigger capillarization of liver sinusoidal endothelial cells, stimulation of immune cells including macrophages and Kupffer cells, and activation of hepatic stellate cells (HSCs), resulting in progression of liver fibrosis. Liver cirrhosis is the terminal state of liver fibrosis and is associated with severe complications, such as liver failure, portal hypertension, and liver cancer. Nevertheless, effective therapy for cirrhosis has not yet been established, and liver transplantation is the only radical treatment for severe cases. Studies investigating HSC activation and regulation of collagen production in the liver have made breakthroughs in recent decades that have advanced the knowledge regarding liver fibrosis pathophysiology. In this review, we summarize molecular mechanisms of liver fibrosis and discuss the development of novel anti-fibrotic therapies.
Negligible risks of hepatocellular carcinoma during biomarker-defined immune-tolerant phase for patients with chronic hepatitis B
Authors: Jeon Mi Young , Kim Beom Kyung , Lee Jae Seung , Lee Hye Won , Park Jun Yong , Kim Do Young , Ahn Sang Hoon , Han Kwang-Hyub , Kim Seung Up
Published: December 2020

Background/Aims: The immune-tolerant (IT) phase of chronic hepatitis B (CHB) patients is not generally indicative of antiviral therapy (AVT). We assessed and compared the risk of hepatocellular carcinoma (HCC) during the IT-phase stringently defined by a low fibrosis-4 (FIB-4) index, compared to that in patients undergoing AVT.Methods: Among 125 untreated patients that were hepatitis B e-antigen positive, hepatitis B virus-DNA >20,000 IU/mL, with normal alanine aminotransferase level from 2012 to 2018, those with a FIB-4 index of <1.45 were classified into the IT-group. The cumulative probability of HCC was estimated using Kaplan-Meier analysis. All patients were assessed until HCC development (intention-to-treat [ITT] analysis), whereas those suspected of experiencing CHB phase switch were assessed using the per-protocol (PP) and censored at the time of phase switch.Results: The cumulative probability of HCC at 1-, 3-, and 5-years among the IT-group was zero, compared to AVT-treated patients with FIB-4 indices <1.45 during the same period: 0.2%, 0.6%, and 1.4%, respectively (P=0.264 for ITT and P=0.533 for PP). Among the initially screened 125 untreated patients, those with a FIB-4 index of ≥1.45 had a higher risk of HCC compared to the IT-group (P=0.005). Furthermore, among AVT-treated patients, those with a FIB-4 index of ≥1.45 had a higher risk of HCC compared to their counterpart (P<0.001).Conclusions: The risk of HCC was negligible in the IT-group stringently defined by a low FIB-4 index. However, given that a higher HCC risk exists among untreated patients with higher FIB-4, appropriate criteria for AVT should be established.
Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study
Authors: Jang Suk-Yong , Rou Woo Sun , Kim Seok Hyun , Lee Byung Seok , Eun Hyuk Soo
Published: December 2020

Background/Aims: Current evidence suggests that liver cirrhosis (LC) causes severe psychological stress and depression, which are risk factors for suicide. Although previous studies reported the association between LC and suicidal thoughts, little is known of its effect on suicidal deaths. Therefore, this study was undertaken to investigate the effect of new-onset LC on suicide.Methods: From the National Health Insurance Service-National Sample Cohort of South Korea, 5,809 incident LC patients and 11,618 risk-set controls matched by propensity score were selected for follow-up. The incidence rate of suicide was estimated using a generalized estimating equation with a Poisson distribution. Effect size was presented as a hazard ratio (HR) using Cox’s proportional hazards model.Results: The incidence rate of suicide was 143.3 cases per 100,000 person years (95% confidence interval [CI], 100.2–205.1) among the LC cohort. The LC patients were 2.37 times more likely to commit suicide compared with matched controls (HR, 2.37; 95% CI, 1.44–3.88). Increased suicide risk was evident within the first 2 years of the follow-up period (HR, 2.59; 95% CI, 1.20–5.60) and among the 18–49-year-old age group (HR, 3.72; 95% CI, 1.45–9.56).Conclusions: Our study found increased risk of suicide in patients with new onset LC, especially during the early period following diagnosis and in younger patients. To decrease this suicide risk, a regular and continuous social support system is required.
Significant down-regulation of growth hormone receptor expression revealed as a new unfavorable prognos- tic factor in hepatitis C virus-related hepatocellular carcinoma
Authors: Lin Ching-Chih , Liu Ta-Wei , Yeh Ming-Lun , Tsai Yi-Shan , Tsai Pei-Chien , Huang Chung-Feng , Huang Jee-Fu , Chuang Wan-Long , Dai Chia-Yen , Yu Ming-Lung
Published: December 2020

Background/Aims: Growth hormone (GH) is the main regulator of somatic growth, metabolism, and gender dimorphism in the liver. GH receptor (GHR) signaling in cancer is derived from a large body of evidence, although the GHR signaling pathway involved in the prognosis of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related HCC, remains unclear. We aimed to explore the expression of GHR and analyze its association with clinicopathologic features and prognosis of patients with chronic hepatitis C and HCC.Methods: The expression of GHR mRNA was investigated by quantitative real-time polymerase chain reaction in paired tumors and adjacent non-tumorous (ANT) liver tissues of 200 patients with chronic hepatitis C and HCC. Western blotting and immunofluorescence assays using the HCV-infected Huh7.5.1 cell model was performed.Results: GHR mRNA was significantly lower in HCV-HCC tissues than in corresponding ANT liver tissues. GHR mRNA and protein levels also decreased in the HCV-infected Huh7.5.1 cell model. Notably, lower GHR expression was associated with age of >60 years (P=0.0111) and worse clinicopathologic characteristics, including alpha-fetoprotein >100 ng/mL (P=0.0403), cirrhosis (P=0.0075), vascular invasion (P=0.0052), pathological stage II–IV (P=0.0002), and albumin ≤4.0 g/dL (P=0.0055), which were linked with poor prognosis of HCC. Most importantly, the high incidence of recurrence and poor survival rates in patients with a low ratio of tumor/ANT GHR (≤0.1) were observed, indicating that low expression levels of GHR had great risk for development of HCC in patients with chronic hepatitis C.Conclusions: Our study demonstrates a significant down-regulation of GHR expression as a new unfavorable independent prognostic factor in patients with chronic hepatitis C and HCC.
SYNTHESIS AND LUMINESCENCE PROPERTIES OF K0,5xBi1-0,5x(MoxV1-x)O4 SOLID SOLUTIONS
Authors: Terebilenko Kateryna , Nedilko Sergii , Petrenko Olga , Slobodyanik Mykola , Chornii Vitalii
Published: December 2020

The conditions of heterovalent substitution in cationic and anionic positions of хK0,5Bi0,5MoO4 – (1-х)BiVO4 system within range of х = 0.1-0.9 with forming of К0,5xBi1-0,5x(MoxV1-x)O4 solid solutions, those possess scheelite-like type structure have been studied. All the samples of series were obtained by solid state technique. It was shown by IR spectroscopy and X-ray diffraction studies that molybdenum and vanadium occupying one crystallographic position with statistical distribution in х = 0.1–0.9 range of substitution. As result a lowering of lattice symmetry from tetragonal to monoclinic take place with increasing of molybdenum content. Charge compensation in system is realized through proportional substitution of bismuth by potassium in (К/Bi)O8 polyhedra. The data on diffuse reflectance indicate that increasing of substitution degree, x, lead to proportional increasing of band gap values from 2.33 to 2.72 eV for the semiconductors obtained. Intrinsic photoluminescence of the samples has been observed at low temperatures but is absent at room temperature. Total intensity of visible luminescence increases with increasing of molybdenum content in К0.5xBi1-0.5x(MoxV1-x)O4 solid solutions. Spectra of photoluminescence consist of wide two-component band with maxima at 620 and 705 nm, respectively. Simultaneous analysis of literature data and dependences of luminescence intensity on molybdenum content allow assumption that short-wavelength component related with centers, those formed on molybdate groups. Long-wavelength component related with vanadate groups. The wide bands at 375 and 410 nm in the photoluminescence excitation spectra were ascribed to absorption transitions in molybdate and vanadate oxyanions, respectively. The solid solutions studied can be used as hosts for luminescent ions or in elaboration of photocatalysts.
THERMODYNAMIC PROPERTIES OF SILVER-CONTAINING COMPOUNDS OF THE Ag–Fe–Sn–S SYSTEM OBTAINED BY LOW-TEMPERATURE SOLID-STATE SYNTHESIS
Authors: Moroz Mykola , Reshetnyak Oleksandr , Demchenko Pavlo , Prokhorenko Myroslava , Soliak Lyudmyla , Rudyk Bohdan , Pereviznyk Orest , Prokhorenko Serhii
Published: December 2020

The existence of the AgFeS2 and Ag2FeS2 compounds in the equilibrium concentration space of the Ag–Fe–S system was established by the EMF method. Investigations were performed in the electrochemical cells (ECCs) of the type (−) С | Ag | SЕ | R(Ag+) | PЕ | С (+), where C is the inert electrode (graphite), Ag is the negative (left) electrode, SE is the solid electrolyte, PE is the positive (right) electrode, R(Ag+) is the region of Ag+ diffusion into PE. Ag2GeS3 glass was used as the solid-state electrolyte with purely Ag+ ionic conductivity. The SnS2–FeS2–Ag2FeS2 (A) phase region of the Ag–Fe–Sn–S system is formed with the participation of three-component compounds. The cross-sections AgFeS2–Ag2FeSnS4, AgFeS2–Ag2FeSn3S8, and AgFeS2–SnS2 carry out the division of (A). Spatial position of the two-phases FeS2–AgFeS2, AgFeS2–Ag2FeS2 and three-phases AgFeS2–Ag2FeSn3S8–SnS2, AgFeS2–Ag2FeSnS4–Ag2FeSn3S8 regions of (A) regarding the point of silver was used to write the equations of the overall potential-forming reactions. Reactions were realized in the positive electrodes of ECCs. PE at the stage of the cell preparation is a well-mixed composition of finely ground (particle size ~5 μm) of the compounds Ag2S, FeS, FeS2 and Ag2S, FeS, FeS2, SnS2 in two- and three-phases regions of (A), respectively. The ratios of compounds in PE of ECCs were determined from the equations of the overall potential-forming reactions in respective phase regions. The decomposition of the metastable set of binary compounds and the synthesis of the equilibrium set of phases were carried out in the nanoscale region of the PE of ECC in contact with SE, i.e. in the R(Ag+) region. The Ag+ ions displaced from the left electrode to the right one for thermodynamic reasons act as nucleation centers for the equilibrium compounds. The process of forming the equilibrium set of phases in the R(Ag+) region for the particle size of the metastable phase mixture ~5 μm and Т=580 K took less than 72 h. The linear dependencies of EMF vs T of ECCs with PE of two- and three-phases regions were established in the ranges of (455–519) K and (450–514) K, respectively. Based on these dependencies, the standard thermodynamic quantities of the AgFeS2, Ag2FeS2, Ag2FeSnS4, and Ag2FeSn3S8 compounds were experimentally determined for the first time. The reliability of the established equilibrium sets of phases that provide the potential-forming reactions in ECCs was confirmed by the coincidence of the calculated and literature values of the Gibbs energy of the Ag2FeSnS4 and Ag2FeSn3S8 compounds.
Türkiye’nin Yerel ve Bölgesel Otoriteleri İhracata Dayalı Şehir Rekabetçiliğini Önemsiyor mu?
Authors: DEMİRBAĞ Orkun , ÖZDEMİR Muhlis , ŞİMŞEK DEMİRBAĞ Kübra
Published: December 2020

Ekonomik globalleşme, yerel dinamikleri doğrudan etkilemiş ve rekabetin yeni bir formu olan kent rekabetçiliğinin literatürde kendisine yer bulmasını sağlamıştır. Kent rekabetçiliğine yönelik çalışmalar yapılmış olmasına rağmen, yerel ve bölgesel otoritelerin kent rekabetçiliğine olan katkıları hâlâ önemli bir araştırma boşluğudur. Bu çalışmada, rekabetçilik göstergesi olarak “ihracat” kavramına odaklanılmış ve Türkiye’deki kentler 2015-2017 yılları arasındaki ihracat değerlerine göre TOPSIS yöntemi ile analize tabi tutulmuştur. İlk on sırayı İstanbul, İzmir, Bursa, Gaziantep, Kocaeli, Trabzon, Mersin, Ankara, Manisa ve Hatay illeri paylaşmaktadır. Bu illerin belediye, ticaret-sanayi odası ve bölgesel kalkınma ajansı gibi otoriteleri tarafından hazırlanan Stratejik/Bölge Planlarında rekabetçiliğe ilişkin vurgular içerik analizi ile irdelenmiştir.
Türkiye’deki Ekmeklik Buğday (Triticum aestivum L.) Çeşitlerinin Çeşit Ayrım Karakterleri Yönünden Değerlendirilmesi
Authors: AKTAŞ Bekir
Published: December 2020

Bu araştırma; 2015-2016, 2016-2017 ve 2017-2018 yetiştirme dönemlerinde, Ankara (Yenikent) ve Manisa (Beydere) lokasyonlarında, 110 ekmeklik buğday çeşidi ile yürütülmüştür. Uluslararası Yeni Bitki Çeşitlerini Koruma Birliği’nce (UPOV) oluşturulmuş ekmeklik buğday çeşit özellik belgesinde yer alan 26 karaktere göre, ülkemizdeki çeşitlerin morfolojik karakterizasyonunun yapılması amaçlanmıştır. Çeşitlerin gelişme tabiatının belirlenmesi amacıyla ilkbahar döneminde ayrıca denemeler kurulmuştur. Çeşitlerin bayrak yaprak kulakçıklarında genel olarak antosiyanin oluşumu gözlemlenmemiştir. Genotipler %92.7 oranında yarı dik, orta ve yarı yatık formda bitki büyüme şekli göstermiştir. Başaklanma zamanında çeşitlerin %70.9’u erken, erken-orta ve orta notlarında toplanmıştır. Bayrak yaprak kını ve sapın başağa bağlandığı kısımda kuvvetli ve çok kuvvetli mumsuluk oluşumları gözlenmiştir. Bitki boyu bakımından genotiplerin %86.4’ü kısa-orta, orta ve orta-uzun gözlem notuna sahiptir. İncelenen çeşitlerin %81.8’inin kılçıklı ve %96.4’ünün ise beyaz başaklı olduğu belirlenmiştir. Tane rengi bakımından çeşitlerin %70.9’u kırmızı, %29.1’i beyaz renktedir. Çeşit ayrım kriteri olması yanında tarımsal açıdan da önemli bir karakter olan gelişme tabiatında; çeşitlerin %56.3’ü kışlık, %18.2’si alternatif ve %25.5’inin yazlık tipte olduğu gözlemlenmiştir.
Перспективи розвитку сімейних фермерських господарств та прогалини в правовому регулюванні їх діяльності
Authors: Покальчук М. Ю. , Дорошенко Р.В. , Шанталій К.С.
Published: December 2020

Стаття присвячена дослідженню сучасного стану правової регламентації інсти­туту фермерства. Авторами проаналізовано низку нормативно-правових актів часів УРСР, які регулювали порядок створення та діяльності селянських (фермерських) господарств. Висвітлено еволюцію фермерського господарства, починаючи з часів УРСР і до сьогодення. У статті досліджено поняття фермерського господарства крізь призму вітчизняного та зарубіжного законодавства. Проаналізовано Закон України від 19.06.2003р. № 973-15 «Про фермерське господарство», Господарський кодекс України, Податковий кодекс України та інші законодавчі акти, які встановлюють правове ре­гулювання сімейних фермерських господарств в Україні. Авторами вивчено норми Закону, які регулюють порядок створення та діяльності сімейних фермерських гос­подарств. Також досліджено стан законодавства щодо прогалин у правовому регу­люванні сімейних фермерських господарств.
Окремі аспекти забезпечення права на охорону здоров’я адміністративно-правовими засобами
Authors: Муляр Г.В.
Published: December 2020

У статті здійснено аналіз сучасного розуміння змісту права на охорону здоров’я та адміністративно-правових засобів його забезпечення. Звернуто увагу на повноту та ефективність забезпечення права на охорону здоров’я адміністративно-правовими засобами. Визначено зміст права на охорону здоров’я та його універсальний (право кожного, а не виключно громадян) та комплексний (фізична, психічна та соціальна складові) характер. Розглянуто адміністративно-правові засоби забезпечення права на охорону здоров’я в Україні. Підтримано позицію про умовний поділ адміністративно-правових засобів на регулятивні, превентивні та примусові. Наголошено на пріоритеті превентивних засобів. Здійснено аналіз адміністративно-правових засобів забезпечення права на охорону здоров’я на предмет повноти та ефективності. Зроблено висновок на необхідності зосередження медичної реформи, насамперед на гарантуванні рівного доступу до медичної допомоги на всіх рівнях (медичних гарантіях) та прогалинах за окремими складовими, що утворюють право на охорону здоров’я.
Компетенція органів місцевого самоврядування на території Галичини в другій половині ХІХ століття
Authors: Бутирін Є. О.
Published: December 2020

У статті здійснено історико-правовий аналіз розмежування компетенції органів місцевого самоврядування в Галичині ІІ пол. ХІХ ст. З'ясовано, що визначення нових адміністративних одиниць – громад ‒ відбувалося за земельним кадастром 1848 р., який було складено ще напередодні березневої революції. Реорганізація місцевого самоврядування в імперії середини ХІХ ст. майже не торкнулася правового статусу поміщицьких земель, хіба дещо було обмежено повноваження поміщика. Зроблено висновки, що спочатку селяни не усвідомлювали значущості тих реформ, які відбулися, та доволі зневажливо ставилися до своїх щойно набутих прав, проте з часом ради громадські довели свою дієвість, і на початку ХХ ст. не в одному селі вже точилася гостра боротьба між різними партіями за мандати депутатів, а особливо ‒ за посаду війта.
Базовий державний соціальний симулякр
Authors: Лук’янчиков О.М.
Published: December 2020

У статті розкрито сутність базового державного соціального стандарту (прожиткового мінімуму) d сенсі концепту «симулякр» Жана Бодріяра. Автором обґрунтовується, що правова категорія «прожитковий мінімум» є чистим симулякром, оскільки він базується на нормативно-правовому акті, який визнаний протиправним та нечинним, а його розмір не відповідає (і це визнається державою!) фактичному розміру прожиткового мінімуму. Як наслідок, мова йде про відсутність реального змісту і в тих правових категоріях (заробітна плата, соціальна пільга тощо), розмір яких розраховується на підставі прожиткового мінімуму.
Домедична підготовка курсантів Луганського державного університету внутрішніх справ імені Е. О. Дідоренка в умовах карантину
Authors: Недоступ М.Ф. М.Ф.
Published: December 2020

У статті розглянуто питання щодо домедичної підготовки курсантів Луганського державного університету внутрішніх справ в умовах карантину, а також проблеми використання виключно дистанційної форми навчання. Проведено аналіз особливостей навчання курсантів при вивченні домедичної підготовки під час карантину з використанням платформ Moodle, Microsoft Teams, поштового клієнта Outlook. Зауважено, що дистанційне навчання може бути ефективною формою засвоення знань із домедичної підготовки, у разі якщо практично оволодіти певними вміннями та навичками для своєчасного та ефективного надання допомоги. Однак зазначено, що його можна застосовувати як вимушений захід, і лише в екстремальних ситуаціях, як, наприклад, чітко не визначений у часі карантин під час пандемії. У разі тривалого застосування такий вид навчання може призвести до зниження навчальної мотивації та неякісної підготовки курсантів. Одночасно, набутий досвід може стати суттєвою підмогою курсантам при підготовці до занять із домедичної підготовки.
Право на свободу мирних зібрань: компаративне дослідження в межах національних правових систем країн пострадянського простору
Authors: Самбор М.А.
Published: December 2020

У статті досліджуються особливості правового регулювання здійснення права на свободу мирних зібрань у країнах пострадянського регіону у межах Євразійського правового простору. Основна увага зосереджена на особливостях юридичної техніки у формулюванні норм позитивного права національних правових систем Білорусі, Молдови, Російської Федерації, Казахстану та Киргизстану та формалізації прав і обов’язків суб’єктів здійснення права на свободу мирних зібрань та повноважень суб’єктів владних повноважень, зокрема їх позитивних та негативних зобов’язань, спрямованих на створення умов свободи здійснення права на мирні зібрання. З використанням порівняльно-правового методу проаналізовано ефективність законодавчих норм у забезпеченні здійснення права на свободу мирних зібрань, питань правового регулювання завчасного сповіщення про здійснення права на свободу мирних зібрань, а також особливості законодавчих норм, які відображають політико-правову волю уповноважених суб’єктів щодо створення умов здійснення права на свободу мирних зібрань. Не залишено поза увагою й застосування наявних норм позитивного права вказаних держав для забезпечення ефективного регулювання суспільних відносин зі здійснення права на свободу мирних зібрань, за результатами чого зроблено висновок про те, що існування спеціальних законодавчих актів не завжди є ефективним засобом гарантування здійснення права на свободу мирних зібрань. Це підтверджується реальними подіями, які мали місце в ряді досліджених країн і під час яких грубо порушувалося право на свободу мирних зібрань.
Якою бути юридичній відповідальності за керування транспортними засобами в стані сп’яніння?
Authors: Веселов М. Ю. , Шелудяков Р. С.
Published: December 2020

Актуальність статті зумовлена спробою національного законодавця криміналізувати правопорушення, пов’язані з керуванням транспортними засобами в стані алкогольного, наркотичного чи іншого сп’яніння або під впливом лікарських препаратів, що знижують увагу та швидкість реакції. У публікації досліджуються особливості правового регулювання цих суспільних відносин, які обумовлюють сучасні проблеми застосування заходів адміністративної та кримінальної відповідальності за вказані правопорушення. На підставі проведеного аналізу сформульовано пропозиції щодо оптимальної (комбінованої) форми юридичної відповідальності за правопорушення, які пов’язані з керуванням транспортними засобами в стані сп’яніння: учинені вперше – адміністративної, повторно – кримінальної.
MATHEMATICAL KNOWLEDGE OF THE RENAISSANCE ERA AND ESTABLISHMENT OF DRAWING AS AN INDEPENDENT FORM OF ART
Authors: Maystrenko-Vakulenko Yuliya
Published: December 2020

This research makes it possible to better understand the reasons why the artistic mindset for world perception and reproduction has drastically changed during a relatively short transition from the Medieval times to the Renaissance, as well as the factors that accelerated the birth of drawing as an independent form of art and prompted the artists of those times to search for ways to picture the tridimensionality of space.Drawing originated as a tool to research the relations between an object and space, as it’s the definition of space that became perceived and imagined on a basis completely different from that of the Medieval times, thanks to scientific discoveries. The crucial change in the art of the Renaissance era: reproduction of the illusion of 3D space and depth was performed through using new mathematical knowledge. Thanks to the research of M. Kuzansky, M. Kopernik, as well as L. B. Alberti, F. Brunelleschi and other scientists, the philosophic thought of the XV century has redeemed the definition of movement, bringing it to the level of eternity: while earlier, in the Medieval tradition, movement was imagined as a sign of earthly imperfection, transience and impermanence. A person’s own view of the world gained its value. It’s exactly this energy of potential movement of the Universe that we can see all the way through drawings by artists of the High Renaissance. The Renaissance space, that has now gained tridimensionality, is imagined as cosmic and immense, with the objects in it being clusters of an energy field. This Renaissance mindset has kickstarted the birth of art academies in Western Europe, where academic drawing was essential in art education. But today requires an update to the principles of teaching. Recognition of the immediate connection between scientific discoveries and direction of development for the art of drawing (both as an independent art form and an academic subject) will make it possible to define ways for its further progression, and avoid stagnation and obsolescence of educational models. Today, drawing is still a tool of world awareness that also allows exploration of its new properties discovered by A. Einstein at the beginning of the XX century. It is also a modern science with more complex, n-dimensional capabilities.
THE HISTORY OF ART WORKSHOP AND TEMPLE CULTURE OF THE NATIONAL ACADEMY OF FINE ARTS AND ARCHITECTURE
Authors: Pylypenko Ivan
Published: December 2020

This article is dedicated to the studio of fine arts and temple culture in the context of the history of the National Academy of Fine Arts and Architecture. Analyzed was the educational program of the studio’s founder,M. Storozhenko. Discovered were the methodological analogies between the studio of monumental painting and templar culture of NAFAA, M. Boychuck’s art workshop and the icon-painting studio of the Kyiv Pechersk Lavra. It was proved that an analysis of historical experience can be useful in the educational process and in the upbringing of the modern painters of sacred (religious) art.
FEATURES OF THE BOOK GRAPHICS OF NIKOLAI STOROZHENKO OF THE 1958–1970S
Authors: Solovei Oles
Published: December 2020

The article considers specific features of the book graphic arts of Mykola Storozhenko of the 1958– 1970s, and also investigates and analyzes the stylistic and compositional features of individual works in the context of evolution of his own artist’s style. At the current time, the subject of the book graphic arts of Mykola Storozhenko remains understudied in Ukrainian art, and the problem of the artist’s creativity in the period of the 1958–1970s has not been practically investigated. Mykola Storozhenko’s book graphic arts, like his monumental works, make a significant contribution to Ukrainian art, and therefore require deep and well-grounded study. By using the method of comparative, formalistic and compositional analysis of the works of Mykola Storozhenko’s book graphic arts of the 1958–1970s, the article reveals the approach of the artist to the form and sculpturesque means of visual and graphic arts as the factors of the experimental space. On the example of illustrative series of works of the certain period it is shown that all means of artistic expression are directed by the artist to create a coherent, emotional and metaphoric space. The issues of visual perception, aesthetic influence and artistic self-sufficiency of each individual illustration were put by the master in a number of priorities, at the level of issue of whole book design.The article emphasizes that Mykola Storozhenko directed the search for new technologies and techniques ofwork in traditional and rarely used graphic arts techniques to create an original, expressive in style of publication, with maximum compliance with the content and contemporary art form.The author considered Mykola Storozhenko’s book graphic arts of the 1958–1970s in the broader art historical context of the stylistic landmarks of his age and issues of his own self-identification.As a result of the study, the author of the article proves that all the means of artistic expression, stylistic and compositional features of each of the stages of Mykola Storozhenko’s creativity in the field of book graphic arts of the 1958–1970s are organic components of the process of evolution of the artist’s own style.All materials of this analytical study are quite important in theoretical and practical application directly in the creative process: to improve the curriculum of composition, as well as an auxiliary methodological material for students of creative specialties and student — art experts.