bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Role of Emotional Intelligence and Role Conflict on Job Burnout among Special Education Teachers
Authors: Olatunji Olabimpe Ajoke , Idemudia Erhabor Sunday , Owoseni Omosolape Olakitan
Published: May 2021

The need to take appropriate care of children with disabilities by the relevant stakeholders as the world moves into the post-COVID era has become imperative. Hence, this work investigated how family-to-work, work-to-family conflicts, and emotional intelligence influenced the four dimensions of job burnout (enthusiasm towards the job, psychological exhaustion, indolence, and guilt) among teachers administering children with disabilities. This was assessed using a cross-sectional online survey design of 276 special education teachers (female = 159; mean age = 32.5, SD = 10.1) from the Nigerian population of teachers. Data were collected using structured psychological tests, including the Work and Family Conflict Scale (WFCS), Emotional Intelligence Scale, and Job Burnout Scale. Results indicated that emotional intelligence predicted all the dimensions of job burnout in teachers except psychological exhaustion. The independent variables failed to predict psychological exhaustion; however, family-to-work conflict independently predicted indolence. Furthermore, the results revealed no gender difference in all four dimensions of job burnout. Based on these findings, it was recommended that an intervention strategy targeting the promotion of emotional intelligence and adequate provision of modern facilities to be used to assist teachers in their special skills delivery.
Brain Injury Clubhouses
Authors: McKay Colleen E. , Young Jason , Johnson Cindi , Seel Ronald T.
Published: May 2021

The National Institutes of Health (NIH) reported that the number of people living with permanent disability from brain injury grows annually as medical technology has advanced in life saving techniques. However, community-based programs which enable brain injury survivors to live productive lives throughout the entire course of recovery have not grown proportionately to meet this the need. Brain Injury Clubhouses were developed to address the need for coordinated, long-term, community-based supports for brain survivors in a community-based setting. Brain Injury Clubhouses are designed to improve the lives of persons with ABI and reduce strain on caregivers and healthcare services

The information in this research brief is designed to provide funders, administrators, policy makers, and other stakeholders with an overview of Brain Injury Clubhouses. The brief also provides outcomes associated with participation in a Brain Injury Clubhouse from a recent research study to provide stakeholders with a better understanding of Brain Injury Clubhouses.
Le management par la pédagogie1
Authors: Souto Lopez Miguel
Published: May 2021

Depuis 2015, le système d’enseignement obligatoire belge francophone est engagé dans un vaste plan de réforme désigné sous le vocable de Pacte pour un enseignement d’excellence. Le Pacte d’excellence introduit une nouvelle forme de régulation institutionnelle fondée sur la contractualisation entre l’autorité publique compétente et les établissements scolaires. À partir du modèle des cités de Boltanski et Thévenot (1991) et d’une analyse lexicographique de documents officiels, cet article étudie, dans une perspective historique, l’introduction progressive des nouvelles logiques de coordination du travail des acteur⋅rice⋅s du système éducatif dont le Pacte d’excellence constitue l’aboutissement. Il montre que la régulation du système éducatif repose sur des logiques managériales particulièrement compatibles avec certains principes pédagogiques.
La liberté d’expression des enseignants en classe : quatre principes directeurs et leurs fondements juridiques
Authors: Maxwell Bruce , McDonough Kevin , Waddington David I.
Published: May 2021

Quelles sont les limites raisonnables encadrant l’enseignement de sujets controversés ? L’article suivant vise la réponse à cette question et propose, pour ce faire, de dégager certains principes juridiquement fondés qui guideront la pratique professionnelle du corps enseignant. L’analyse de la jurisprudence pertinente du Canada et des États-Unis, ainsi que de documents légaux secondaires nous a permis de relever les éléments récurrents sur lesquels se fondent les juges pour évaluer si la liberté d’expression pédagogique a été exercée de façon raisonnable et responsable. Notre analyse dégage quatre principes délimitant l’exercice de la liberté d’expression en enseignement : l’alignement avec le programme, l’impartialité, le non-usage de propos possiblement incendiaires et la pertinence du contenu en fonction de l’âge.
Entre conservatisme et rectitude politique en enseignement supérieur : un commentaire critique sur The coddling of the American mind
Authors: Loignon Guillaume , Béland Sébastien
Published: May 2021

Le livre The coddling of the American mind, par Greg Lukianoff et Jonathan Haidt, a généré beaucoup d’intérêt depuis sa sortie. Nous en proposons une recension critique qui situe d’abord l’ouvrage dans son contexte sociopolitique, puis en résume les idées centrales. Nous présentons ensuite une critique qui s’est concentrée sur les choix et fondements théoriques qui sous-tendent l’ouvrage, puis en évaluons une des propositions centrales, celle d’instaurer un système de discrimination positive envers les professeur⋅e⋅s ayant un alignement politique conservateur. Enfin, nous revenons sur les aspects du livre que nous avons trouvés intéressants et discutons de son utilisation potentielle en classe.
Notes from the editor
Authors: Nimehchisalem Vahid
Published: May 2021

Thanks to our international authors, readers, reviewers, and editorial board members, the April 2021 issue is now released.
Values Education Using the Digital Storytelling Method in Fourth Grade Primary School Students
Authors: Ayten Başak Kasa , Polater Canan
Published: May 2021

In today’s world where technology develops rapidly and young people keep up with this technology, students should both improve their digital literacy and make their learning permanent. Digital storytelling is also a method where the student is active in the learning environment and improves his technological literacy. The present study aims to investigate the use of digital storytelling method in values education in primary school fourth grade. The study was conducted with a case study design, one of the qualitative research methods. The participants of the study consist of 31 students studying in the fourth grade of a primary school in the northwest of Turkey in the spring semester of the 2018-2019 academic year. The data were collected through observations, semi-structured interviews with students and teachers, products produced in the digital storytelling process, and the diaries kept by the second author and students. The descriptive analysis method was used for the analysis of the data. The data obtained in the digital storytelling stages were analyzed using students’ products, video recordings, observations, and the diaries kept by students and the second author while the data obtained from the interviews were analyzed by showing themes, sub-themes, frequencies, and percentages in tables. As the results indicated, the students expressed that their use of technology and story writing skills developed during the digital story process and that they liked dubbing and the picture drawing processes but experienced difficulties due to not being equipped. In addition they underlined that the story presentations allowed them to reinforce and internalize their knowledge about the value of justice.
Manuscript Accepted!: Collaborating on a scholarly publishing symposium for graduate students and early career academic faculty
Authors: Schultz Teresa Auch , Bucy Rosalind , Hunsaker Amy , Shannon Amy , Klenke Chrissy , Winterman Mitch , Arrieta Baro Iñaki
Published: May 2021

INTRODUCTION As academic libraries expand their scholarly communication support, they also need to find ways to help educate graduate students about this area as well as market themselves. DESCRIPTION OF PROGRAM The University of Nevada, Reno Libraries created a one-day symposium, called Manuscript Accepted!, aimed at graduate students and early career faculty that would use faculty and library expertise to lead panels and workshops. This article discusses planning for the event, including collaborating with other on-campus groups, working with publishers for financial support, and planning a program that would meet a variety of needs. Assessment of the first two symposiums, held in 2019 and 2020, shows that attendees valued the event while also highlighting the need for more targeted support for specific areas, such as the humanities. NEXT STEPS The Libraries plans to continue Manuscript Accepted! as a one-day symposium, although it will also look to ways to expand attendance. Finally, the Libraries is investigating ways to create smaller events that could be tied into the Manuscript Acceptance! brand but that help meet other needs of our attendees.
Identification of P2RY13 as an immune-related prognostic biomarker in lung adenocarcinoma: A public database-based retrospective study
Authors: Lin Jiang , Wu Chunlei , Ma Dehua , Hu Quanteng
Published: May 2021

Background

Lung adenocarcinoma (LUAD) is the leading histological subtype of non-small cell lung cancer (NSCLC).

Methods

In the present study, the gene matrixes of LUAD were downloaded from The Cancer Genome Atlas to infer immune and stromal scores with the ‘Estimation of Stromal and Immune cells in Malignant Tumor tissues using Expression data’ (ESTIMATE) algorithm and identified immune-related differentially expressed genes (DEGs) between the high- and low-stromal/immune score groups. Next, all DEGs were subjected to univariate Cox regression and survival analyses to screen out prognostic biomarkers in the tumor microenvironment (TME), and were validated in the Gene Expression Omnibus database. Single-sample gene set enrichment analysis (ssGSEA) was performed to assess the level of tumor-infiltrating immune cells (TIICs) and immune functions, and GSEA was used to identified pathways altered by prognostic biomarkers.

Results

Survival analysis showed that LUAD in the high-immune and stromal score group had a better clinical prognosis. A total of 303 immune-related DEGs were detected. Univariate Cox regression and survival analyses revealed that P2Y purinoceptor 13 (P2RY13) was a favorable factor for the prognosis of LUAD. ssGSEA and Spearman correlation analysis demonstrated that P2RY13 was highly correlated with various TIICs and immune functions. Several immune-associated pathways were enriched between the high- and low-expression P2RY13 groups.

Conclusion

P2RY13 may be a potential prognostic indicator and is highly associated with the TME in LUAD. However, further experimental studies are required to validate the present findings.
ToRQuEMaDA: tool for retrieving queried Eubacteria, metadata and dereplicating assemblies
Authors: Léonard Raphaël R. , Leleu Marie , Van Vlierberghe Mick , Cornet Luc , Kerff Frédéric , Baurain Denis
Published: May 2021

TQMD is a tool for high-performance computing clusters which downloads, stores and produces lists of dereplicated prokaryotic genomes. It has been developed to counter the ever-growing number of prokaryotic genomes and their uneven taxonomic distribution. It is based on word-based alignment-free methods (k-mers), an iterative single-linkage approach and a divide-and-conquer strategy to remain both efficient and scalable. We studied the performance of TQMD by verifying the influence of its parameters and heuristics on the clustering outcome. We further compared TQMD to two other dereplication tools (dRep and Assembly-Dereplicator). Our results showed that TQMD is primarily optimized to dereplicate at higher taxonomic levels (phylum/class), as opposed to the other dereplication tools, but also works at lower taxonomic levels (species/strain) like the other dereplication tools. TQMD is available from source and as a Singularity container at [https://bitbucket.org/phylogeno/tqmd ].
GC-MS ANALYSIS OF CHEMICAL COMPONENTS OF TWO DIFFERENT STAGES OF ROOT PART OF MOOLAK (RAPHANUS SATIVUS LINN.)
Authors: Patel Rajani , Rout Om Prakash , Joshi Pravin Kumar
Published: May 2021

Moolak or Radish (Raphanus sativus Linn.) is grown all over the world. Radish is eaten raw as salad due to its pungent flavor. Tender radish root is consumed with leafy vegetable and radish in its starting stage of bolting is consumed as stew. After late bolting stage, only new leaves produced in inflorescence axis and seeds are consumed as edible substance and mature seeds are used for medicinal purpose like Kushtha (Skin disease). Formulations of Moolak seed is already mentioned in Ayurvedic literatures. Here we are taking tender and early bolt stage of radish where tender is balmoolak and Bolt is vriddha moolak. This study shows the differences in chemical composition of two stages of moolak to know about their medicinal properties, because medicinal properties of herbs are due to phytoconstituents. GC-MS (Gas chromatography - mass spectrometry) technique is used to identify bioactive compounds in methanolic extract of Raphanus sativus. Tender radish (balmoolak) has shown total 38 peaks and Bolt radish (vriddha-moolak) showed total 41 peaks of phytoconstituents. 15 compounds are common among both samples.
CONCEPT OF ABHYANTARA VIDRADHI WITH INSIGHT ON VRIKKA VIDRADHI: A REVIEW
Authors: L P Prashanti , . Sheshashaye , S V Shailaja
Published: May 2021

Vidradhi is a rakta dushti vikara which undergoes rapid suppuration i.e., formation of pooya. Acharya Charaka has explained Vidradhi under Raktavaha Sroto vikara in which Rakta Dushti and Paaka takes place predominantly. Acharya Sushruta has explained ten adhishthana of Abhyantara vidradhi, among these vrikka vidradhi is also mentioned. Vrikka is derived from root word ‘vrikkadane’ meaning to take. Acharya Charaka described Vrikka among 15 kosthanga. He mentioned vrikka as the moola of Medovaha srotas. According to Ashtanga sangraha, Kashyapa Samhita, Bhela Samhita Vrikka is a kosthanga. Vrikka is also a Matruja bhava derived from essence of rakta and medas. Moderners are of view that this brownish, reddish ovoid develops by the mesoderm of the intermediate cell mass. Some of the conditions affecting Vrikka are Mutrasada, Mutrashmari, Vrikka Vidradhi, Vrikka Arbuda. Among them Vrikka Vidradhi can be correlated as Renal abscess. An attempt is made to understand the concept of Abhyantara vidradhi with insight on Vrikka Vidradhi.
Efficacy of Multiple Oppositions Therapy in Children with Speech Sound Disorder
Authors: Hasırcı Sema Uz , Logacev Özlem Ünal
Published: May 2021

Aim: Speech sound disorders (SSD) decrease intelligibility and increase the possibility of experiencing various communication problems. Considering the academic and psychological problems associated with speech sound disorders, the need for early intervention is undisputable. The aim of this study is to investigate the effectiveness of multiple oppositions therapy in Turkish-speaking children with SSD. Material and Method: To determine the effectiveness of multiple oppositions therapy, a multiple probe design across behaviors with probe conditions was employed and nonwords were used as stimuli. The study was performed with three participants aged between 5;0 and 5;8. Two participants received therapy for three target sounds, and one participant received therapy for two target sounds. Results: Participants achieved an accuracy (i.e., correct production) rate of 50%-85% during the intervention sessions. In the successive follow-up sessions, which took place two months after the therapy sessions ended, all participants met the accuracy criterion of 90% correct production with the exception of one target sound. In addition to the target sounds, there were many non-target sounds that were added to the phonetic repertoire of each participant by the time of the follow-up session. Conclusion: The findings indicate that multiple oppositions therapy performed with nonwords is effective in promoting the production and generalization of speech sounds over a short period of time. This study calls for further replication with a larger population involving participants who have different speech sound problems.
Consequences of the Covid-19 Pandemic on Zero Access to Technology Users in Bangladesh
Authors: Rahman Md. Shahinur , Sabbir Md. Mahiuddin , Kaium Dr. Md. Abdul , Nomi Marzia , Zahan Israt , Islam Mazharul
Published: May 2021

Coronavirus disease 2019 (COVID-19) has been holding back the developments of the world and forcing humanity to a burdened edge. Within this unprecedented health emergency, the education sector has been facing one of the most unpredicted challenges. This paper aims to analyze the consequences of the COVID-19 pandemic on zero access to technology users in the primary education level of Bangladesh. This study employs an in-depth interview with 48 students, 12 teachers, and 15 parents at Tala Upazila under Satkhira district. The study's findings reveal that in primary education level, students who have zero access to technologies have been suffering significantly during the COVID-19 pandemic. As they have limited scope to study at home, many are about to leave school permanently to support their parents’ earnings while facing financial insolvency. In this regard, this research can help the education authorities and policymakers facilitate this segment's learning process in such a disruption and minimize school dropouts at their very early stage of education.
Testing of a Drawing Toy for Children with Blindness: The Kuwu Experience
Authors: Escobar José-Pablo , Castro Camila , Garolera Marion , Sepúlveda Angélica , Cruz Martín Santa , Rosas Ricardo
Published: May 2021

Play is a fundamental activity in early childhood and a source of cognitive development. One ludic activity in early childhood is drawing, a semiotic activity in which children can build and transform symbols and meanings in a way to reflect their thoughts and emotions. However, drawing has a visual component that is a challenge for some children with blindness or visual impairment. This research aims to evaluate a prototype of a haptic pencil called Kuwu. Through user’s usability tests and expert heuristic inspection, we evaluated 10 children with blindness or visual impairments between 5 and 8 years old, from 2 schools of Santiago, Chile. Heuristics evaluation shows the minimalist design, ease, and flexibility of use of the pencil that allows children to draw independently. Usability testing is a foundational phase in any technological development, especially when creating from a universal design perspective.
The Effect of Parent-Child Communication on Self-Protection Skills at Pre-schoolers: The Body Safety Training Interventions in Turkey
Authors: Tunc Gulseren Citak , Sezgin Elif Yalcintas , Ulus Leyla
Published: May 2021

Objective: Parents are key partners in preventing child sexual abuse (CSA). Body safety tarining (BST) aims to preventing CSA. The first aim is to examine parents knowledge of CSA and interventions of the BST. Secondly, to ev aluate the effect of parents' BST interventions on giving the child self-protection skills. Method: Sample included 92 parents and their 3-to 6 year-old preschool children. In the first stage of the study, WIST (What If Situations Test) was applied to the pre-schoolers. Secondly, data were collected from the parents about the knowledge of CSA and BST interventions. Results: Parents' have high CSA knowledge (M = 7.33 SD = 1.31). The proportion of parents who have knowledge BST is limited (32.6%). However, despite this limited knowledge, the number of those who talk to the child is higher (82.6%). There was no difference between the WIST sub-scale score; appropriate recognition, inappropriate recognition, saying, telling skills and Personal Safety Questionnaire (p > 0.05). The scores of doing and reporting skills were found to be statistically significant high (p < 0.05). Conclusions: Parents have high CSA knowledge, but the impact of BST interventions to their children on gaining the ability to self-protection skills is limited.
Dyslexic Arabic Students in the Arab Countries: A Systematic Review of Assistive Technology Progress and Recommendations
Authors: Alsswey Ahmed , El-Qirem Fuad Ali , Tarawneh Mohammed Hassan Al
Published: May 2021

Dyslexia is quite possibly the most widely recognized learning troubles. Literacy is a critical life skill; low literacy skills inhibit educational advancement. Even a few dyslexic students may affect the broad educational experience of all students. Unfortunately, dyslexia is a relatively unknown phenomenon in Arabic academic communities. Arab countries are experiencing a rapid increase in dyslexic students; consequently, there is an urgent need to investigate dyslexia and its associated student assistive technology (AT). A systematic review was conducted on AT developed for dyslexic Arabic students to understand AT’s benefits and challenges. Our research found that in addition to learning strategies, several other factors contributed to the adoption (or lack thereof) of AT in Arab classrooms, including environmental, social and cultural factors. This study’s findings can assist AT developers and educational policymakers in efficiently designing and implementing AT.
Parental Competencies in Mothers of Infants with Disabilities and their Relationship to Adaptive Behavior and Motor Development
Authors: Meléndez-Jara Carmen Magali , Ramírez-Sáenz Natalia Luisa , Tafur-Mendoza Arnold Alejandro
Published: May 2021

The purpose of the study was to determine the relationship between mothers' parental competencies with the adaptive behavior and motor development of their children with disabilities and to compare parental competencies according to the mother's employment status, the mother's educational level, and family type. The study was empirical following an associative strategy. The sample consisted of 242 biological mothers and their children attending the Early Intervention Program in Lima, Peru, aged between 1 month and 4 years and 9 months. The Positive Parenting Scale (e2p) and the Battelle Developmental Inventory (BDI) were used as measurement instruments. The results show a small positive relationship between global parental competencies and muscle control and attention adaptive behaviors. Linking parental competencies showed a small relationship with motor development and adaptive behavior tasks. On the other hand, parental competencies showed small differences according to the mother's employment status and family type. Finally, the theoretical and practical implications of the study are discussed based on the findings obtained.
Emotional, Behavioral and Cognitive Self-Regulation of Children with Learning Disabilities in Arabic Mainstreamed and Specialized Middle-School Classrooms in Kuwait
Authors: Bustan Sana Ahmad Al , Thuwaikh Suad Al- , Rajab Ali , Ghareeb Dana Al
Published: May 2021

This research examines how emotional, behavioral and cognitive self-regulation in children with learning disabilities is affected by the school environment in Kuwait. A quantitative design approach was chosen to gather data on emotional, behavioral and cognitive self-regulation using a bespoke self-regulation Likert scale; 56 students from grades 6-9 were surveyed from mainstreamed and specialized classrooms in Kuwait. The analysis showed statistically significant differences in emotional self-regulation; children with learning disabilities in mainstream classrooms performed lower than expected compared to children in specialized classroom. Results showed that girls in specialized classes had lower behavioral self-regulation than the boys. All mainstreamed children with learning disabilities scored lower across all axis compared to students in specialized classroom. Children’s self-regulation across all axis declined in grades 7 and 8 compared to those in grade 6; however, children in specialized classrooms recovered self-regulation skills in grade 9 compared to mainstreamed children’s self-regulation which continued to plateau through to grade 9. The study was influenced by types of services each mainstreamed and specialized class offered. Furthermore, the researchers emphasize introducing emotional self-regulation training for classroom teachers and assistants in mainstreamed classrooms. They suggest specific characteristics specialized classes can implement to recover self-regulation across all axis.
Parenting Stress, Social Support and Parental Characteristic in Parents of ASD Children
Authors: Putri Asri Mutiara , Lutfianawati Dewi
Published: May 2021

Children with autism spectrum disorder (ASD) have developmental problems that can be a source of stress for parents. This study aimed to measures the parenting stress experienced by parents of ASD children in relation to social support and parental characteristics, namely education level and income. This study involved 50 parents of ASD children who send their children to several special schools in Lampung, Indonesia. Research data were obtained using the parenting stress index, social support scale, and parental characteristics data. The collected data were analyzed using multiple regression analysis. The results of the study found that parents of ASD children experienced moderate parenting stress. Social support and a high level of education were found to have a significant effect on parenting stress, while income did not. Social support was found to be the strongest predictor of parenting stress. The results of the study illustrate that the parenting stress experienced by parents of ASD children in Indonesia is not as high as found in other countries. This study has implications on the emphasis of social support as an interventions to deal with parenting stress in parents of ASD children in Indonesia.
A Study of Cultural and Heritage Products and Activities in Kampung Cherating Baru and Kampung Kubang Ikan, Kuantan, Pahang
Authors: Rahman Norshafriman Bin Abd , Shamsudin Shahril Nizam , Kong Chow Soon
Published: May 2021

This exploratory study was designated to discover the potential cultural and heritage products and activities of the communities in Kampung Cherating Baru and Kampung Kubang Ikan. This research could help to create more employments among the local community and provided economic and social benefits when they participate in the tourism activities. The data for this research was collected through observations, unstructured interviews, with the emphasis on ethnography study about the community. The findings for this research were based on the analysis checklists on the following resources – Natural Resources, Cultural Resources, Community Analysis, Site Analysis and Environment Assessment. The findings indicated that, from the overall analysis of the various resources, Kampung Cherating Baru and Kampung Kubang Ikan had their own unique cultural products and activities that could be developed the two areas into a cultural and heritage destination.
Exploring Cultural Tourism Products at Kampung Tanjung Api, Kuantan, Pahang
Authors: Ishak Nor Khomar , Rahman Mohd Noor Akhir Abd , Foresti Fatimah Ibrahim , Saaidin Munira
Published: May 2021

This purpose of the research was to determine if there were cultural tourism products in Tanjung Api in the district of Kuala Kuantan, in the state of Pahang. To that end, the research process would require the understanding of the community, an analysis of the site, and the availability and conditions of the natural resources of the area. This study was conducted via unstructured interview, observations, and the use of the ethnography approach in the research methodology. The data collection method was guided through the use of five resources measuring instruments: Site Analysis, Community Analysis, Cultural Resources Analysis, Natural Resources Analysis, and Environment Assessment. The findings indicated the availably of tourism products such as the martial art called silat cekak, fishing and crab catching activities, interesting sights at the village such as the wet market and night market, visiting the jetty area, the old British graveyard and the uniquely design mosque.
The Success Factors Affecting Street Food Stalls for Gastronomic Tourism Competitiveness: A Case of Petaling Jaya Old Town
Authors: May Rachel Yong Yuen , Aziz Khursiah Abd , Latif Rohaizah Abd , Latip Muhammad Safuan Abdul , Kwan Tan Chee , Kadir Mohamad Arif Abdul
Published: May 2021

Recently, worldwide demand for food provided on streets is growing swiftly. Realizing the need to recognize the mindset and market tastes of consumers towards street food stalls as street food is now strongly associated with tourism and is considered a significant motivator for travelers to visit the destination. The local cuisine served by these food stalls provides a direct and sincere connection by experiencing local history, society, and people through food and beverages. This research project, therefore, explore street food stall vendors for their success variables in a small town called Petaling Jaya Old Town of Selangor as a case study zone. This location is selected as street food stalls are numerous and can be of generational origin. Notwithstanding its varied culinary offerings, this area was not fully known as a renowned gastronomic destination in Malaysia. By adopting the aforementioned case study approach, there were a total of five in-depth interviews with street food stall owners regarding trader profile and marketing strategies, and a sample of 100 street food consumers participated in a structured questionnaire where they were asked about their attitude and food preference to street food stalls. The key results indicated that the drivers investigated in this research project directed to the success factors of street food stalls in terms of gastronomic tourism while examining data that aimed to function as a guideline for food vendors and policymakers alike, seeking a better understanding of customers ' food preferences and behaviors outside consumer numbers. Focusing on the competitiveness of a tourist destination in Petaling Jaya Old Town should therefore also be recognized as a method rather than a complete condition, as it requires time and resource effort, and analysis on ways of effectively managing the street food market in the upcoming requirements with more thought.
A importância dos fóruns nacionais de mestrados profissionais
Authors: Amaral Ana Karênina de Freitas Jordão do
Published: May 2021

Os Fóruns Nacionais dos Programas de Mestrado Profissional em Enfermagem têm sido reconhecidos como espaços para aproximação e diálogo entre os atores dos segmentos que compõem os Programas (coordenadores, docentes, mestrandos), bem como, das instituições e serviços parceiros aos quais são atendidas as demandas de qualificação Profissional.
The nurse and the model of living of the renal transplanted user: seeking the quality of life / O enfermeiro e o modo de viver do usuário transplantado renal: buscando a qualidade de vida
Authors: Pedroso Vanessa Soares Mendes , Siqueira Hedi Crecencia Heckler , Andrade Gustavo Baade , Medeiros Adriane Calvetti , Tolfo Fernando , Moura Bibiane
Published: May 2021

RESUMO: Objetivo: conhecer a produção científica sobre o modo de viver do usuário transplantado renal no seu ambiente domiciliar e as ações educativas do enfermeiro capazes de promover a qualidade de vida. Método: Estudo de caráter exploratório e descritivo, que segue os passos da revisão integrativa, que possibilita ao pesquisador problematizar a temática por meio do agrupamento e sistematização do que já foi produzido cientificamente e incorporá-los à prática assistencial. Resultado: O total de 58 estudos incluídos na amostra. Após a leitura criteriosa dos resumos 50 estudos não possuíam aderência com a temática em questão e foram excluídos. Portanto, 08 artigos foram lidos na integra e compõem a amostra. Conclusão: Conhecer o modo de viver do usuário transplantado renal permite que o foco do cuidado, além de individual, seja baseado em relações humanas.
Relationship between suicidal behavior and eating disorders: a systematic review / Relação entre comportamento suicida e transtornos alimentares: uma revisão sistematizada
Authors: Araújo Veras Juliana Lourenço , Ximenes Rosana Christine Cavalcanti , Vasconcelos Flávia Maria Nassar , Medeiros Bruna Ferreira , Sougey Everton Botelho
Published: May 2021

Objetivo: Realizar uma revisão sistematizada da literatura acerca dos transtornos alimentares e sua relação com o comportamento suicida, analisando o conteúdo das publicações. Métodos: Foi Realizada uma busca sistematizada em bases de dados eletrônicas (Medline, Lilacs, Adolec e Pubmed), com foco em artigos publicados entre 2003 e 2014. Resultados: Dentre os estudos selecionados, a anorexia nervosa foi o distúrbio alimentar mais referido pelas publicações. No caso da bulimia nervosa, as taxas de tentativas de suicídio e/ou comportamentos auto agressivos são maiores entre indivíduos que utilizam uma compensação múltipla de comportamentos purgativos. Sobre os fatores de risco associados,evidenciou-se que os transtornos de comportamento, os transtornos emocionais e a dependência química apresentam-se descritos em todas as publicações. Conclusão: Ainda são escassos os trabalhos que investigam profundamente a relação entre transtornos alimentares e o comportamento suicida, porém é possível verificar que a presença concomitante pode comprometer ainda mais a saúde do paciente.
Monitoring levels of circulating cell‐free DNA in patients with metastatic colorectal cancer as a potential biomarker of responses to regorafenib treatment
Authors: Pastor Brice , André Thierry , Henriques Julie , Trouilloud Isabelle , Tournigand Christophe , Jary Marine , Mazard Thibault , Louvet Christophe , Azan Simon , Bauer Audrey , Roch Benoit , Sanchez Cynthia , Vernerey Dewi , Thierry Alain R. , Adenis Antoine
Published: May 2021

Circulating cell‐free DNA (cfDNA) contains circulating tumor DNA (ctDNA), which can be obtained from serial liquid biopsies to enable tumor genome analysis throughout the course of treatment. We investigated cfDNA and mutant ctDNA as potential biomarkers to predict the best outcomes of regorafenib‐treated metastatic colorectal cancer (mCRC) patients. We analyzed longitudinally collected plasma cfDNA of 43 mCRC patients prospectively enrolled in the phase II TEXCAN trial by IntPlex qPCR. Qualitative (KRAS, NRAS, BRAFV600E mutations) and quantitative (total cfDNA concentration, mutant ctDNA concentration, mutant ctDNA fraction) parameters were correlated with overall survival (OS) and progression‐free survival (PFS). When examined as classes or continuous variables, the concentrations of total cfDNA, mutant ctDNA, and, partly, mutant ctDNA fraction prior to regorafenib treatment correlated with OS. Patients with baseline cfDNA > 26 ng·mL−1 had shorter OS than those with cfDNA value below this threshold (4.0 vs 6.9 months; log‐rank P = 0.0366). Patients with baseline mutant ctDNA > 2 ng·mL−1 had shorter OS than those with mutant ctDNA below this threshold (log‐rank P = 0.0154). We show that pretreatment cfDNA and mutant ctDNA levels may identify mCRC patients that may benefit from regorafenib treatment.
Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non‐small cell lung cancer
Authors: Pal Jagriti , Becker Andrea C. , Dhamija Sonam , Seiler Jeanette , Abdelkarim Mahmoud , Sharma Yogita , Behr Jürgen , Meng Chen , Ludwig Christina , Kuster Bernhard , Diederichs Sven
Published: May 2021

Cell migration is an essential process in health and in disease, including cancer metastasis. A comprehensive inventory of migration factors is nonetheless lacking—in part due to the difficulty in assessing migration using high‐throughput technologies. Hence, there are currently very few screens that systematically reveal factors controlling cell migration. Here, we introduce MigExpress as a platform for the ‘identification of Migration control genes by differential Expression’. MigExpress exploits the combination of in‐depth molecular profiling and the robust quantitative analysis of migration capacity in a broad panel of samples and identifies migration‐associated genes by their differential expression in slow‐ versus fast‐migrating cells. We applied MigExpress to investigate non‐small cell lung cancer (NSCLC), which is the most frequent cause of cancer mortality mainly due to metastasis. In 54 NSCLC cell lines, we comprehensively determined mRNA and protein expression. Correlating the transcriptome and proteome profiles with the quantified migration properties led to the discovery and validation of FLNC, DSE, CPA4, TUBB6, and BICC1 as migration control factors in NSCLC cells, which were also negatively correlated with patient survival. Notably, FLNC was the least expressed filamin in NSCLC, but the only one controlling cell migration and correlating with patient survival and metastatic disease stage. In our study, we present MigExpress as a new method for the systematic analysis of migration factors and provide a comprehensive resource of transcriptomic and proteomic data of NSCLC cell lines related to cell migration.
Do polyproline II helix associations modulate biomolecular condensates?
Authors: Mompeán Miguel , Oroz Javier , Laurents Douglas V.
Published: May 2021

Biomolecular condensates are microdroplets that form inside cells and serve to selectively concentrate proteins, RNAs and other molecules for a variety of physiological functions, but can contribute to cancer, neurodegenerative diseases and viral infections. The formation of these condensates is driven by weak, transient interactions between molecules. These weak associations can operate at the level of whole protein domains, elements of secondary structure or even moieties composed of just a few atoms. Different types of condensates do not generally combine to form larger microdroplets, suggesting that each uses a distinct class of attractive interactions. Here, we address whether polyproline II (PPII) helices mediate condensate formation. By combining with PPII‐binding elements such as GYF, WW, profilin, SH3 or OCRE domains, PPII helices help form lipid rafts, nuclear speckles, P‐body‐like neuronal granules, enhancer complexes and other condensates. The number of PPII helical tracts or tandem PPII‐binding domains can strongly influence condensate stability. Many PPII helices have a low content of proline residues, which hinders their identification. Recently, we characterized the NMR spectral properties of a Gly‐rich, Pro‐poor protein composed of six PPII helices. Based on those results, we predicted that many Gly‐rich segments may form PPII helices and interact with PPII‐binding domains. This prediction is being tested and could join the palette of verified interactions contributing to biomolecular condensate formation.
A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth
Authors: Pandey Rajan , Gupta Priya , Mohmmed Asif , Malhotra Pawan , Gupta Dinesh
Published: May 2021

Post‐translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver (PfPRL) is secreted and is an essential phosphatase. Here, we expressed PfPRL in a heterologous expression system, and then purified and characterized its phosphatase activity. We found that Novartis_003209, a previously identified inhibitor, inhibited the PfPRL phosphatase activity of recombinant PfPRL and blocked in vitro parasite growth in a dose‐dependent manner. Further, in silico docking analysis of Novartis_003209 with all four P. falciparum tyrosine phosphatases (PTP) demonstrated that Novartis_003209 is a Plasmodium PTP inhibitor. Overall, our results identify a scaffold as a potential starting point to design a PTP‐specific inhibitor.
Differentiation between thyroid‐associated orbitopathy and Graves’ disease by iTRAQ‐based quantitative proteomic analysis
Authors: Kang Jianshu , Li Yunqin , Zhao Zhijian , Zhang Hong
Published: May 2021

Graves’ ophthalmopathy, also known as thyroid‐associated orbitopathy (TAO), is the most common inflammatory eye disease in adults. The most common etiology for TAO is Graves’ disease (GD); however, proteomic research focusing on differences between GD and TAO is limited. This study aimed to identify differentially expressed proteins between thyroid‐associated orbitopathy (TAO) and GD. Furthermore, we sought to explore the pathogenesis of TAO and elucidate the differentiation process via specific markers. Serum samples of three patients with TAO, GD, and healthy controls, respectively, were collected. These samples were measured using the iTRAQ technique coupled with mass spectrometry. Differentially expressed proteins in TAO and GD were identified by proteomics; 3172 quantified proteins were identified. Compared with TAO, we identified 110 differential proteins (27 proteins were upregulated and 83 were downregulated). In addition, these differentially expressed proteins were closely associated with cellular processes, metabolic processes, macromolecular complexes, signal transduction, and the immune system. The corresponding functions were protein, calcium ion, and nucleic acid binding. Among the differential proteins, MYH11, P4HB, and C4A were markedly upregulated in TAO patients and have been reported to participate in apoptosis, autophagy, the inflammatory response, and the immune system. A protein–protein interaction network analysis was performed. Proteomics demonstrated valuable large‐scale protein‐related information for expounding the pathogenic mechanism underlying TAO. This research provides new insights and potential targets for studying GD with TAO.
SNRPC promotes hepatocellular carcinoma cell motility by inducing epithelial‐mesenchymal transition
Authors: Zhang Yuanping , Qiu Jiliang , Zuo Dinglan , Yuan Yichuan , Qiu Yuxiong , Qiao Liang , He Wei , Li Binkui , Yuan Yunfei
Published: May 2021

The therapeutic outcome of hepatocellular carcinoma (HCC) remains unsatisfactory because of poor response and acquired drug resistance. To better elucidate the molecular mechanisms of HCC, here we used three Gene Expression Omnibus datasets to identify potential oncogenes, and thereby identified small nuclear ribonucleoprotein polypeptide C (SNRPC). We report that SNRPC is highly up‐regulated in HCC tissues as determined using immunohistochemistry assays of samples from a cohort of 224 patients with HCC, and overexpression of SNRPC was correlated with multiple tumors, advanced stage, and poor outcome. Kaplan–Meier analysis confirmed that patients with high SNRPC expression exhibited shorter survival in four independent HCC cohorts (all P < 0.05). Furthermore, SNRPC mutations are significantly more frequent in HCC tissues than in normal liver tissues and are an early event in the development of HCC. Functional network analysis suggested that SNRPC is linked to the regulation of ribosome, spliceosome, and proteasome signaling. Subsequently, gain‐ and loss‐of‐function assays showed that SNRPC promotes the motility and epithelial–mesenchymal transition of HCC cells in vitro. SNRPC expression was negatively correlated with the infiltration of CD4+ T cells, macrophage cells, and neutrophil cells (all P < 0.05), as determined by analyzing the TIMER (Tumor IMmune Estimation Resource) database. In conclusion, our findings suggest that SNRPC has a potential role in epithelial–mesenchymal transition and motility in HCC.
The meaning of practicing calligraphy in the written works of architect Seiichi Shirai: Focusing on the relation to the Theory of Tradition
Authors: Hato Kosuke
Published: May 2021

Seiichi Shirai was an architect, but in his later years he spent a lot of time practicing calligraphy. When the characteristics of this activity are compared to his Theory of Tradition, it can be said that his intentions for both activities were similar. In addition to the commonality of emphasizing “utility,” provided by the Theory of Tradition, the concept of grasping the inner potential of an object without being misled by its external form and source, can be realized by “ascetic practices,” which can cause something to exceed consciousness and form by practicing calligraphy.
Plasma calcitonin gene‐related peptide (CGRP) in migraine and endometriosis during the menstrual cycle
Authors: Raffaelli Bianca , Overeem Lucas Hendrik , Mecklenburg Jasper , Hofacker Maxi Dana , Knoth Henriette , Nowak Claus Peter , Neeb Lars , Ebert Andreas Dietmar , Sehouli Jalid , Mechsner Sylvia , Reuter Uwe
Published: May 2021

Objective

Migraine, endometriosis, and the comorbidity of both are frequent pain disorders of special relevance for women. The neuropeptide calcitonin gene‐related peptide (CGRP) is critically involved in migraine, and circumstantial evidence suggests a role in endometriosis. We assessed CGRP levels at different times of menstrual cycle in four groups: healthy women, women with migraine or endometriosis and with the comorbidity of both.

Methods

Women with episodic migraine and women with a histologically confirmed endometriosis were recruited from specialized centers. For CGRP determination with a commercial enzyme immunoassay kit, cubital vein blood samples were collected on menstrual cycle day 2 ± 2 (during menstruation) and on day 15 ± 2 (periovulatory period). The primary endpoint of the study was the absolute difference of CGRP plasma levels between the menstrual and the periovulatory phase of all study groups. Groups were compared using nonparametric test procedures.

Results

A total of 124 women were included in the study. The change of CGRP plasma levels between menstruation and the periovulatory period was different between groups (p = 0.007). Women with comorbid migraine and endometriosis showed an increase of CGRP in the menstrual phase of +6.32 (interquartile range, IQR −3.64–13.60) compared to the periovulatory time, while healthy controls had a decrease of −10.14 (−22.54–0.91, p = 0.004). CGRP levels were different in the periovulatory phase among groups (p = 0.008), with highest values in healthy controls.

Interpretation

CGRP levels change significantly during the menstrual cycle. Different patterns in women with the comorbidity point to a deviant regulation of CGRP release.