bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of The Implementation Game-Based-Learning in Increasing Student Learning Outcomes
Authors: Maulida Nabila Nur , Sukadi Sukadi , Rahayu Sri
Published: March 2023

The government has now started to lower the Implementation of Community Activity Restrictions level during the Covid-19 pandemic, but it cannot be predicted that it will return to normal. This makes the world of education to be able to choose a learning model whose implementation is flexible both offline and online. Learning outcomes are an indication of the success of a learning process. In line with the previous explanation, the purpose of this study is to determine the effectiveness of implementing Game-Based-Learning (GBL) learning-assisted Kahoot! with digital media in improving student learning outcomes in the subject of Construction Cost Estimation. This research is a pre-experimental design in the form of a one-group pretest-posttest research design. The results of the study show that the application of GBL produces an average score that is more effective than before the treatment, where the value obtained has exceeded the category of determining the completeness of learning outcomes for productive subjects that have been determined. To see the picture that GBL can improve student learning outcomes, it can be seen from the results of the test that the increase in N-Gain has increased with a moderate category. Based on the research findings and discussion in terms of the process and improvement of student learning outcomes, the N-Gain Score of 65.00% is categorized as quite effective, so the application of GBL can be applied according to current conditions and can be more optimal.Keywords: Construction Cost Estimation, Game-Based-Learning (GBL), Kahoot!, Learning Outcomes
Marcas prosódicas de la intensificación con adverbios de grado en el español de la Ciudad de México
Authors: Bermúdez Castillo Dominic Lilian
Published: March 2023

En la presente investigación se analizan las marcas de intensificación prosódica en construcciones con el adverbio de grado muy en hablantes de la Ciudad de México. Se aplicó una prueba para la obtención de datos con diferentes grados de control: mediante una entrevista semidirigida y una prueba de lectura. El objetivo principal de este trabajo es identificar los recursos prosódicos utilizados para intensificar partes específicas del discurso, en este caso un adverbio de grado, con el fin de describir y analizar una posible relación entre los compuestos semántico-sintáctico y prosódicos.
Estudio acústico de la duración de las vocales del habla en uso a partir del corpus Preseea-Medellín
Authors: Rodríguez Ordóñez Franklin
Published: March 2023

Los objetivos de este trabajo fueron establecer los valores de duración vocálica e identificar en qué medida diversas variables referentes al timbre, a la estructura de la sílaba, de la palabra y del enunciado se correlacionan con la conformación el parámetro acústico de la duración. A partir de una muestra tomada de entrevistas semidirigidas del corpus Preseea-Medellín, se pudo identificar un valor de duración vocálica intrínseca de 65,32 ms; además, los factores que generan variaciones en la duración están más correlacionados con las estructuras prosódicas del enunciado que con la estructura interna de la sílaba o de la palabra.
influencia del género narrativo y de la función de trasfondo de los verbos en imperfecto de indicativo en la posposición de yo
Authors: Arrieta Coyotl Abraham Samuel , Orozco Vaca María Leonor
Published: March 2023

En esta investigación analizamos la posposición del pronombre yo. Para ello, consideramos cuatro factores lingüísticos: la correferencia, la semántica verbal, el tam según sus funciones discursivas y el género textual. Los datos analizados provienen de tres corpus de habla de la Ciudad de México. Los resultados muestran que la posposición de yo es favorecida básicamente en el género narrativo con verbos en imperfecto de indicativo, lo cual sugiere que la posposición de yo tiene una función de trasfondo congruente con la del imperfecto de indicativo en el género narrativo.
Where the wild sociocriticism are: aproximación sociocrítica al álbum Ilustrado Donde viven los monstruos
Authors: Negrete-Portillo Rafael
Published: March 2023

La sociocrítica se aleja de la tendencia común de otras perspectivas de crítica literaria sociológica —que eliden profundizar en estructuras textuales— y enuncia un modo de investigar la complejidad social dentro del propio texto. Nuestro estudio propone realizar una aproximación sociocrítica a un álbum ilustrado con la intención de cotejar la eficiencia de esta disciplina si se aplica a la literatura infantil. A partir de la definición de «álbum ilustrado» y de sus componentes, se avanzará por la microsemiótica intratextual, en observancia de las contradicciones estructurales para llegar a su proyección socio-ideológica en el relato infantil.
A Review of Rock Slope Stability Assessment Practice in Malaysia
Authors: Rahim Afiq F.A. , Rafek Abdul G.M. , Serasa Ailie S. , Jaapar Abd Rasid , Goh Thian Lai , Roslee Rodeano , Lee Khai Ern , Nguyen Xuan Huy , Tran Van Xuan
Published: March 2023

Rock slope stability assessment in Malaysia has become increasingly important as new developments encroach hillsides around major cities. This article reviews historical case studies to present a general picture of rock slope assessment practice in Malaysia, especially on methods and output of the case studies. Common methods include use of locally developed rating systems, Rock Mass Rating (RMR) and its derivatives, kinematic analysis, and numerical analysis. Application of these methods must be suitable with site conditions, while its advantages and disadvantages must be recognized by the assessor. Emergence of new technologies greatly improves the speed and quality of data acquisition provided. A total of 39 case studies on different lithologies were examined, in which progress were notable from kinematic analysis-based assessments to incorporation of rating systems and numerical analysis. This article recommends several improvements for rock slope assessment practice. These include an establishment of a local good practice guide in the assessment, incorporation of numerical analysis into standard practice, improving utilization of new technologies, more attention to the influence of weathering, and consideration of seismic influence in seismically active regions. Utilization of numerical methods and other contemporary methods reflects increasing understanding of rock mechanics which is vital to rock slope stability assessment among local practitioners. Improved rock slope assessment allows for a more accurate stability determination and decisive mitigation measure recommendations, which is to be done by competent engineering geologists, in line with Geologist Act 2008.
Batch and Continuous Flow Treatment Studies of Trichloroethylene Contaminated in Water by Silver and Cerium Doped Zinc Oxide Adsorption and Photocatalysis
Authors: Tulaphol Sarttrawut , Grisdanurak Nurak , Anariba Franklin , Tongcumpou Chantra , Khamdahsag Pummarin
Published: March 2023

The development of photocatalytic treatment in continuous flow systems to be more practical is challenging. This research aimed to study batch and continuous flow treatment of trichloroethylene (TCE) contaminated in water by silver and cerium doped zinc oxide (0.005Ag-0.005Ce-ZnO) visible light driven photocatalyst. This catalyst was selected to represent the green route synthesis with simplicity and ease of upscaling. The 0.005Ag-0.005Ce-ZnO powder was synthesized using sticky rice flour as a template. Mechanical coating of the 0.005Ag-0.005Ce-ZnO powder on activated alumina (Al2O3) beads was done to improve the appropriate packing in the fixed bed columns. Characterization of 0.005Ag-0.005Ce-ZnO showed a higher response to visible light and smaller crystallite size compared to zinc oxide synthesized with the same method. Using sticky rice starch as a template increased the uniform distribution of the elements. The photocatalytic batch test over 0.005Ag-0.005Ce-ZnO powder, 0.30 g/100 mL, could remove TCE up to 80% in 180 min. The decrease of TCE via photocatalysis compared to volatilization, adsorption, and photolysis presented the predominance of photocatalysis. Langmuir-Hinshelwood kinetics described that the decrease of TCE more depended on the reaction than adsorption. In addition, the TCE degradation steadily remained at 80-90% along the run of 0.005Ag-0.005Ce-ZnO@Al2O3 photocatalysis under visible light from both warm white lamps and sunlight in the continuous flow system. Besides photocatalysis, TCE adsorption on 0.005Ag-0.005Ce-ZnO@Al2O3 packed in the columns showed significant results. Our findings presented the possibility of applying the photocatalytic continuous flow system to remove TCE in industrial wastewater.
Methylene Blue Adsorption by Acid Post-Treated Low Temperature Biochar Derived from Banana (Musa acuminata) Pseudo Stem
Authors: Baharim Noor Halini , Sjahrir Fridelina , Mohd Taib Rahmad , Idris Norazlina , Tuan Daud Tuan Azmar
Published: March 2023

The adsorption of methylene blue dye solution using low temperature biochar (PSB) and acid post-treated biochar (PT-PSB) derived from banana (Musa acuminata) pseudo stem was investigated. The raw material was oven-dried at 105 °C for 24 h and then carbonized via slow pyrolysis at a low temperature of 300 °C for 1 h. The biochar was further treated with 1.0 M HCl for 24 h. At room temperature, batch adsorption experiments were conducted to determine the removal efficiency of methylene blue at different parameters; solution pH (3-10), adsorbent dosage (0.05-0.30 g) and initial concentration (25-150 mg/L). The results exhibited that the highest removal efficiency of methylene blue using PSB was 96.6% at optimum solution pH 6 with the adsorbent dosage of 0.20 g. Nevertheless, the better removal efficiency of methylene blue using PT-PSB was identified (99.3%) at optimum solution pH 7 and adsorbent dosage of 0.25 g. The initial concentration of 25 mg/L showed the maximum removal efficiency for both PSB and PT-PSB. The adsorption isotherm analysis showed that both PSB and PT-PSB were better fitted with the Freundlich isotherm model which indicates multilayer adsorption onto the heterogeneous surface of the adsorbents. Kinetic data showed that the adsorption of methylene blue onto PSB and PT-PSB was well fitted by the pseudo-second order model, indicating chemical adsorption. Banana pseudo stem showed great potential to be used as an efficient low-cost and environmentally friendly adsorbent for the removal of methylene blue from aqueous solution.
First Principles Study of Toxic Gas Molecules Adsorption on Group IVA (C, Si, Ge) 2-Dimensional Materials
Authors: Zainal Mohd Azizul , Chan Kar Tim , Zainuddin Hishamuddin , Mohd Shah Nurisya , Raymond Ooi Chong Heng
Published: March 2023

Two-dimensional materials from group IVA namely graphene, silicene, and germanene have gained research interest in various fields of applications recently due to their extraordinary properties. These substrates have been successfully synthesized and are found to have interesting gas sensing capabilities. In this work, first-principles study using density functional theory is carried out to investigate the adsorption of toxic gases such as CO, Cl2, NO2, and COCl2 on these monolayers. We analyze the best adsorption site and orientation for these molecules on the monolayers by calculating the adsorption energy. Charge transfer, the density of state (DOS) and band diagram calculations are performed to explore the changes in their electronic and structural properties due to the adsorbed gas molecules. As for the sensing performance, crude estimations of the sensitivity and recovery time are performed. The results show that silicene and germanene monolayers are better at detecting CO and NO2 as compared to graphene. They have a short recovery time for CO but a long recovery time for NO2 implying that they are better for scavenging NO2. Besides, silicene is also a better gas sensor for chlorine gas with a 44 min recovery time. As for graphene, it is the best gas sensor for phosgene among the substrates. This study gives a clear prediction of substrates for the detection of these toxic gases.
On the Earthquake Distribution Modeling in Sumatra by Cauchy Cluster Process: Comparing Log-Linear and Log-Additive Intensity Models
Authors: Susanto Tabita Yuni , Choiruddin Achmad , Purnomo Jerry Dwi Trijoyo
Published: March 2023

Inhomogeneous cluster point processes have been considered for modeling the distribution of earthquake epicenters with the spatial trend and clustering patterns. In particular, the spatial trend is assessed by the intensity model involving geological variables. However, for intensity with a log-linear form, it may be too restrictive and not appropriate for earthquake distribution. In this study, we consider the Cauchy cluster process with the log-additive intensity model to analyze the distribution of major earthquake occurrences in Sumatra, Indonesia. The estimation procedure follows the standard two-step estimation technique, where the first step adapts the method for the Generalized Additive Models (GAMs) using penalized iteratively reweighted least squares (PIRLS) algorithm, and the second step employs the second-order composite likelihood. For the earthquake analysis in Sumatra, the log-additive intensity shows more flexibility to determine the contribution of each geological factor, especially to capture the effect of the nearest distance to the fault which is far from log-linear. In addition, compared to the log-linear model, the Cauchy cluster process with a log-additive intensity model performs better with a smaller Akaike Information Criterion’s (AIC) value and a sharper envelope K-function. The estimated number of mainshocks is around 114 with aftershocks spread by 14 km around the mainshocks. We detect three hotspots for the major earthquake in Sumatra: the northern part (Aceh and North Sumatra), the western part (Mentawai, Nias, and Simeulue), and Bengkulu.
New Mixed Ni(II), Cu(II), and Co(II) Complexes derived from 2-((2-mercaptophenylimino)methyl)-4-methoxyphenol and 1,10-Phenanthroline: Synthesis and Characterization
Authors: SOĞUKÖMEROĞULLARI Hatice Gamze , SARIOĞLU Ahmet Oral
Published: March 2023

Three new mixed Ni(II), Co(II) and Cu(II) complexes have been created using 2-((2-mercaptophenylimino)methyl)-4-methoxyphenol and 1,10-phenanthroline. FT-IR, Elemental analysis, magnetic susceptibility, UV-Vis and molar conductivity technique have all been used to explore the structural characterisation of these compounds. Magnetic susceptibility readings for the L-Cu, L-Ni, and L-Co complexes were 1.97 BM, 2.92 BM, and 2.84 BM, respectively. The L-Co complex is thought to be antiferromagnetic. The structures of the mixed ligand metal complexes are thought to be octahedral geometry. There are no conductivity properties in the complexes; however, they exhibit molar conductivities that range from 2.46 to 9.04 µS/cm.
A comparison of Apache Solr and Elasticsearch technologies in support of large-scale data analysis
Authors: DENİZ Ayşenur , ELÖMER Muhammed Mehdi , AYDIN Ahmet Arif
Published: March 2023

In the era of big data, data has never been more important because it contains hidden insights. Additionally, it is necessary and challenging to extract usable information from enormous volumes of data. When attempting to perform data processing and analytics in a variety of domains, developers of data-intensive systems have consequently met several challenges. In addition, full-text search is one of the most significant components of big data processing and analytics for discovering fragments of required data among large volumes of data. Due to the importance of the subject, this article begins with an examination of the characteristics, capabilities, and technical comparisons of full-text search technologies, followed by a systematic comparison of Apache Solr and Elasticsearch in terms of indexing times and queries on three separate datasets. According to our findings, based on default configuration, Apache Solr has better performance when looking at indexing times measured on three machines with different hardware specifications. Likewise, Apache Solr outperforms Elasticsearch in seven out of ten search queries. Regarding our results, on computers with restricted hardware resources, we recommend utilizing Apache Solr instead of Elasticsearch. In addition, this study provides researchers and developers of data-intensive systems with a complete comparison and suggestions for choosing the most effective full-text search engine for their task.
MODERNISATION FEATURES OF SOCIALISM WITH CHINESE CHARACTERISTICS DOCTRINE IN THE NEW ERA (following the 20th National Congress of the Communist Party of China)
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Rudenko Sergii , Yevdokymova Liudmyla ,   Taras Shevchenko National University of Kyiv, Ukraine
Published: March 2023

This article presents an analytical overview of the critical modernisation features of Socialism with Chinese characteristics doctrine in the new era, which was proposed at the 20th National Congress of the Communist Party of China. The authors reconstructed and systematically represented the central philosophical and political principles of the doctrine of Socialism with Chinese characteristics in the context of the fundamental principles of Chinese Marxism. The authors also analysed and presented in a systematic form the essence and basic theoretical principles of the concept of Socialism with Chinese characteristics following Xi Jinping's works and reports. The study includes a comparative analysis that concludes with the critical features of the modern concept of socialism with Chinese characteristics. These features embrace the need for constant modernisation of the very doctrine of socialism with Chinese characteristics, the state management system, as well as social and cultural practices, which are possible through the implementation of innovations and the integration of modern philosophical thought with traditional Chinese philosophy and culture. The article concludes that the main feature of the modernisation of Socialism with Chinese characteristics at the current stage reveals in the development and implementation of a system of creative practices at the level of everyday culture, high-tech sectors of social production and the practice of intercultural communication within the framework of China's Belt and Road Initiative. In the discussion, the authors argue that implementing creative practices and creative industries could become an effective tool for developing China's Belt and Road Initiative in European countries and improving mutual understanding in the intercultural communication practices between China, European countries, and Ukraine.
Comparison of the effects of TIVA and inhalation anesthetic techniques on olfactory functions and olfactory memory: a randomized prospective study
Authors: SEZER Üstün , OKYAY Rahşan Dilek , AYOĞLU Hilal , KÖKSAL Bengü Gülhan , KÜÇÜKOSMAN Gamze , PİŞKİN Özcan , GENÇOĞLU Nilay Nur , AYOĞLU Ferruh , ÇINAR Fikret , ÖZKOÇAK TURAN Işıl
Published: March 2023

Purpose: This study aimed to investigate the effects of different general anesthesia procedures on postoperative olfactory functions and olfactory memory.

Materials and Methods: This prospective study was conducted with 97 patients. Patients were divided into three groups based on anesthesia induction and maintenance technique: Group P (induction and maintenance with propofol), Group PS (induction with propofol, maintenance with sevoflurane), and Group S (induction with sevoflurane, maintenance with sevoflurane). Butanol threshold and olfactory identification tests were administered 30 minutes (min) before the operation (T1) and 30 min (T2), 8 hours (h) (T3) and 24 h (T4) after the operation.

Results: Butanol threshold values were increased at the T2 time point compared to baseline in all groups, which returned to baseline values at T3 only in Group P. There was a significant difference between Group P and Group S in terms of butanol threshold values at all time points except T1. When olfactory identification increased at T3 and T4 compared to baseline in Group P, there was a significant difference between T2, T3, and T4 time points in Group S, and between T2 and T3 time points in Group PS as compared to Group P.

Conclusion: Propofol only causes a temporary impairment in olfactory functions in the early period and does not alter olfactory memory.
Association of infertility and methylenetetrahydrofolate reductase genotypes in Turkish couples
Authors: PAZARBAŞI Halil İbrahim , YILMAZ Bertan , ÜRÜNSAK İbrahim Ferhat , KESER Nurşen , KORKMAZ GÜVENMEZ Hatice
Published: March 2023

Purpose: Infertility is described as unexplained when all of the tests of a basic infertility evaluation return within normal limits and present in 15% of infertile couples. Some studies indicate that there is an association between methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations and unexplained infertility in male or female grown adults. The objective of this study was to analyze the distributions of MTHFR’s C677T and A1298C genotypes in couples with unexplained fertility problems (UFP) and healthy controls.

Materials and Methods: Two common variants C677T and A1298C of the MTHFR gene were screened in infertile couples (n =60 for C677T polymorphism; n=62 for A1298C polymorphism) and controls from the Cukurova region of Turkey. C677T and A1298C mutations in the MTHFR gene were detected by the SNP analysis (Fragment analysis) kit of the multiplex PCR amplification/ligation products. Homocysteine levels (in serum) were determined by the human hcy ELISA kit and folate values were determined by the Beckman coulter Unicel DxI 800 chemiluminescence test kit at the Central Laboratory of Balcali Hospital in Cukurova University.

Results: In this study, an association between unexplained infertility and MTHFR C677T polymorphism was not found. However, we found an association between MTHFR A1298C polymorphism and males with UFP (%7) and controls (%19). A statistically significant difference was observed between the infertile and control groups regarding i) the folate and homocysteine values of MTHFR C677T heterozygous individuals; ii) the homocysteine values of the MTHFR C677T normal individuals; iii) the homocysteine values of MTHFR A1298C heterozygous, normal and homozygous individuals; iv) the MTHFR C677T heterozygous and normal individuals; v) the homocysteine values of MTHFR C677T normal individuals; vi) the folate values of the MTHFR A1298C heterozygous and normal individuals.

Conclusion: The etiopathogenesis of unexplained infertility remains largely unexplored. However, the relationship of the folate/homocysteine findings with the MTHFR polymorphisms under study is not clear. The results of our study support a relationship between the MTHFR A1298C polymorphism and male fertility problems.
Contribution of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurements in determining response to treatment in lung cancer
Authors: BULUT Eser , KOŞUCU Polat , OZLU Tevfik , KOSUCU Muge , KAVGACI Halil , ÇAKIR İsmet Miraç , COSKUNER BULUT Arzu
Published: March 2023

Purpose: The purpose of this study was to evaluate the role of diffusion-weighted imaging (DWI) in evaluating tumor response to chemotherapy in stage III-IV lung cancer.

Materials and Methods: Chest and DWI were performed with 3T MRI before and after 3 courses of chemotherapy on 32 patients diagnosed with stage III-IV lung cancer. DWI were acquired with a b factor of 50, 400 and 800 s/mm using a single-shot echo-planar sequence. Histopathological types before and after chemotherapy were compared by measuring mean apparent diffusion coefficient (mADC) values on the basis of regression and progression groups.

Results: 32 cases, 7 (18.5%) were in the progression group (PG), and 25 (81.5%) were in the regression group (RG). mADC in the PG was 1.06±0.43 x 10ˉ³ before chemotherapy and 0.85±0.24 x 10ˉ³ after chemotherapy. mADC in the RG was 0.92±0.27 x 10ˉ³ before chemotherapy and 1.20±0.26 x 10ˉ³ after chemotherapy. There was a statistically significant difference between the mADC values in the PG and RG before and after chemotherapy. There was no statistically significant difference in mADC values before and after chemotherapy in small cell lung cancer (SCLC) tumor type in the PG . There was a statistically significant difference in mADC values before and after chemotherapy in SCLC and non-small cell lung cancer (NSCLC) tumor types in the RG and NSCLC tumor type in the PG

Conclusion: DWI and ADC measurements can be used in assessing response to treatment in malignant pulmonary tumors.
Effect of electromyography biofeedback treatment on reaction time, pain, hand grip strength, and upper extremity functional status in patients with carpal tunnel syndrome.
Authors: ÇİFTÇİ Rukiye , KURTOĞLU Ahmet , ÇELEBİ Kahraman Özgür
Published: March 2023

Purpose: The aim of the study was to investigate the effect of electromyography biofeedback (EMG-BF), which in addition to conventional electrophysical therapy (EPT) commonly used in the symptomatic treatment of carpal tunnel syndrome (CTS), on motor parameters such as strength and reaction time and symptomatic functional parameters such as pain and function of the upper extremity.

Materials and Methods: Patients diagnosed with CTS were divided into two groups. The first group was the conventional EPT group only (control group, n=46 hands), and the second group was the group that received EMG-BF in addition to the conventional EPT treatment (research group, n=42 hands). The pain (VAS), hand grip strength (HGS), audio-visual reaction time (ART-VRT), and upper extremity disability (Quick DASH) of patients in both groups were assessed before and after the treatment program.

Results: After treatment, VRT, ART, HGS, and Quick DASH were significantly better in favor of the EPT +EMG- BF group. Before treatment, resting state (VASr), mobile state (VASm), and night state (VASn) VAS values were similar between the two groups. After training, the VAS -values were better in favor of the EPT +EMG- BF –group.

Conclusion: Although EPT applications provide effective results in the rehabilitation of CTS, EMG-BF applications together with EPT applications provide more meaningful results in the rehabilitation process.
Topical Application of Ursolic Acid Cream Ameliorates Imiquimod-induced Plaque Psoriasis in BALB/c Mice
Authors: Derera Precious , Sumithra M. , Chitra V. , Mrinalini R. , Begum Rukaiah Fatma
Published: March 2023

The valued studies of alternative psoriasis treatment options are in a much higher need among the Scientific Community. This study aimed to evaluate the anti-psoriatic activity of ursolic acid cream in imiquimod-induced psoriasis in BALB/c mice. The creams containing ursolic acid, a pentacyclic triterpenoid at percentages of 0.1 and 0.2% were formulated. The pH, spreadability, physical characteristics and acute dermal irritation of the cream were assessed. Animals were grouped into five each having 6 animals. Clobetasol, a topical corticosteroid, was used as the standard. One group was used as control and four groups were treated with the formulated imiquimod cream while receiving treatment. Parameters such as skin inflammation severity, ear thickness, plasma level of interleukins (IL)-17, histology of the back of the skin and spleen weight were evaluated. Erythema and scales were scored on a daily basis with the 0.1 and 0.2% ursolic acid cream significantly ameliorating psoriatic-like symptoms in a manner comparable to clobetasol. Imiquimod-induced epidermal hyperplasia and inflammation were inhibited by topical application of ursolic acid as shown by the results of histopathology. Spleens of the positive control group were larger in comparison with the rest of the groups. BALB/c mice treated with ursolic acid creams exhibited a decrease in the plasma levels of cytokines IL-17 when compared to the positive control group. The result of this study provided an insight that topical application of ursolic acid can be a potential treatment for psoriasis.
Ayurvedic Management of Polypoidal Choroidal Vasculopathy (PCV) -A Case Report
Authors: Shanti K.
Published: March 2023

Polypoidal Choroidal Vasculopathy (PCV), a subtype of neovascular Age-related Macular Degenerationn (AMD) is a disease characterized by persistent, recurrent serous leakage and hemorrhage in the macular area, mostly seen in the elderly population. While contemporary science offers anti Vasculo Endothelial Growth Factor (VEG-F) monotherapy and combination with Photodynamic Therapy (PDT), the outcomes of these remain doubtful. Repeated anti-VEG-F injections not only cause a financial and mental burden on the patients with no or very little visual outcome. Chronicity paves the way to complete loss of vision due to exudative retinal detachment. Symptoms like Raktavatdristi (to visualize things as if through a column of blood), Pashyatiaasyamanaasikam (unable to recognize the faces of people around) and aaviladarshanam (blurred vision) were suggestive of Raktaja Timira (an eye disease caused by Raktadosa) associated with Kaphadushti), according to Ayurveda.
A 77-year-old male patient diagnosed with PCV sought Ayurvedic treatment after being advised to undergo anti-VEG-F therapy for the 3rd time in a row. His treatment comprised internal medicines consisting of Mahatiktakakashaya, Guduchyadikashaya, Chandraprabhavati and Avipathichurna; external treatments like Pratimarshanasya with Anu tailam and Gandusha with Triphalakashaya; Kriyakalpa (eye treatments) like Seka, Vidalaka, Aschotana and Anjana karma.
At the end of 3 months of Ayurvedic treatment, his visual acuity in the right eye improved to 6/6, Optical Coherence Tomography (OCT) affirmed complete normalcy of the macula and Fundus examination confirmed the absence of neovascularization. Ayurvedic treatment is effective in reversing the process of neovascularization, thereby bringing about the marked visual outcome in PCV. Such patients should be encouraged to adopt Ayurvedic treatment instead of expensive and invasive treatment procedures like intra-vitreal injections even when the absolute effects of these remain doubtful.
Estimation of Digoxin in Chloroform Extract of Moringa concanensis Leaves Using Newly Developed and Validated RP-HPLC Method
Authors: Dodiya Tanvi , Patil Vaishali
Published: March 2023

Cardiac glycosides are the secondary metabolites that are used in atrial fibrillation and atrial flutter as it binds with the sodium-potassium ATPase pump and increases the force of contraction. There are two types of cardiac glycosides i.e. cardenolides and bufadienolides. Digoxin is a cardenolide type of cardiac glycoside. Digoxin is found in chloroform extract of Moringa concanensis leaves. In the present study, the reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated to determine the content of digoxin in chloroform extract of M. concanensis leaves from three different geographical sources. The chromatographic method was developed at 220 nm wavelength with an Acetonitrile: Water: 1% Orthophosphoric acid (50:50:0.1 %V/V/V) mobile phase. In this method, the digoxin shows linearity in the range of 10 – 50 μg/ml with a regression coefficient of 0.995. The Limit of detection (LOD) and Limit of quantitation (LOQ) was found to be 0.232 μg/ml and 0.703 μg/ml respectively.
Camphora Augments Humoral Mediated Immunity and Decreases Delayed type Hypersensitivity in BALB/c Mice
Authors: Saka Vara Prasad , Kumar G. V. Narasimha , Goswami Abanti , Verma Digvijay , Gupta Pankaj
Published: March 2023

Background: Immunomodulation encompasses all therapeutic interventions aimed at modifying the immune response. The immune response augments are desirable to prevent infection in immunodeficiency states and fight established diseases. In this context, the present study investigated the effect of the homeopathic medicine, Camphora, in 6CH, 30CH, and 200CH potencies on immunomodulation in experimental animals. The acute oral toxicity study was also carried out in 6CH, 30CH, and 200CH potencies to determine the safe dose volume for the immunomodulatory study. Methodology: Acute oral toxicity studies of Camphora in 6CH, 30CH, and 200CH potencies were carried out as per OECD guideline 423 with slight modifications in Wistar albino rats. Humoral immunity, i.e., primary and secondary humoral responses, was assessed by measuring the hemagglutination titre of sheep red blood cells. Delayed-Type Hypersensitivity (DTH) was evaluated by measuring footpad thickness in BALB/c mice. Results: Camphora in 6CH, 30CH and 200CH potencies at a dose volume of 2000 µl/kg did not cause any mortality in the rats when administered as a single dose. Camphora in 6CH, 30CH and 200CH potencies showed augmented primary and secondary humoral responses against the SRBC antigen in BALB/c mice. However, the values were statistically non-significant except in the case of 6 CH potency (p<0.01), which showed statistically significant primary anti-SRBC antibodies. In the DTH assay, Camphora in 6CH, 30CH and 200CH potencies significantly decreased the paw volume ratio after 24 hrs of SRBC injection in the paw, thus insinuating its role in reducing cell-mediated immunity. Camphora in 6CH, 30CH and 200CH potencies also showed enhanced antibody titres and decreased paw volume compared to vehicle control, i.e. dispensing alcohol, suggesting that the effect was imminent because of Camphora. Conclusion: The study results indicate that Camphora in 6CH, 30CH, and 200 CH potencies is safe up to a dose volume of 2000 µl/kg when administered as a single dose, augments the primary and secondary humoral immunity, and decreases DTH in experimental animals. The current study’s findings suggest that Camphora might be useful as an immunomodulator in treating immune system disorders and infectious diseases and require further investigation to investigate its mechanism of action.
Multi-Targeted Prediction of the Antiviral Effect of Momordica charantia extract based on Network Pharmacology
Authors: Das Soma , Laxman Gajbhiye Rahul , Kumar Nitesh , Sarkar Dhrubajyoti
Published: March 2023

The fruits of Momordica charantia (Bitter Gourd) are well known for centuries as a natural remedy for the treatment of various ailments. In this study, we aimed to explore the metabolites present in both varieties of small and big bitter gourds and to explore the multitarget mechanism of M. charantia in antiviral infection by utilizing network pharmacology. The study design involves the identification of the compounds in both varieties of the bitter gourd by Agilent QTOFLC-MS/MS system, followed by screening for ADME to analyze the possible mechanism of action, disease association, protein-protein interactions and major pathways involved therein.  Several Databases used were IMPAT, BindingDB, Swiss Target Prediction, STRING, DAVID, and KEGG databases, and algorithms were used to gather information. To visualize the network, Cytoscape 3.2.1 was used. As a result, a total of 22 and 27 compounds were detected from small and big bitter gourds respectively. . The molecules from M.charantia provide an antiviral response through the involvement of pathways like toll-like receptor pathway, PI3/AKT pathway, NF-kappa B signalling pathway, and cytokine-cytokine receptor interaction. Moreover, the core target genes termed ‘Hub Genes” were also identified through Cyto-hubba. The main mechanisms of M. charantia were acquired by investigating the enrichment of each cluster through functional association clustering analysis. Our results exposed the mechanism of M. charantia against viral infection by multi-component, multi-target, and multi-pathway study combinations.
Development and Validation of Novel High-Performance Liquid Chromatography Method for Simultaneous Estimation of p-Cymene and Aloe-emodin
Authors: Khristi Avani , Bisht Jyotanshi
Published: March 2023

The objective of the present investigation was to develop a novel, accurate, precise, and linear High-Performance Liquid Chromatographic (HPLC) method for the simultaneous estimation of p-Cymene and aloe-emodin in the novel topical herbal formulation and validated as per ICH guidelines. In the current study, good chromatographic separation was achieved in isocratic mode using an HPLC C18 column (250mm × 4.6), 5 μm, and a mobile phase consisting of acetonitrile:water in the ratio of 80:20, at a flow rate of 1.0 mL/min and column temperature maintained at 25°C. The response obtained was monitored at 225 nm wavelength with a UV-Visible detector. The retention times of Aloe-emodin and p-Cymene were found to be 4.3 min and 9.0 min respectively. Linearity was established for both p-Cymene and aloe-emodin in the range of 10-90 µg/mL, respectively. For the method, % Recovery was found in the range of 99.67-100.51 % for p-Cymene and 98.68-100.4 % for aloe-emodin respectively. The LOD and LOQ were found to be 0.01 and 0.04 for p-Cymene and 0.12 and 0.36 for aloe-emodin respectively. This method can be successfully employed for simultaneous quantitative analysis of p-Cymene and Aloe-emodin in the novel topical herbal formulation.
Formulation and Evaluation of Sustained Release Linezolid Tablet using Natural Antibacterial Polymer - Aegle marmelos
Authors: Jani Rupalben , Patel Shrey
Published: March 2023

The objective of the current research study was to formulate and evaluate a sustained-release linezolid tablet using the natural antibacterial polymer Aegle marmelos. The natural gum of Aegle marmelos is becoming increasingly used in pharmaceutical formulations as a beneficial medication with excipients. Natural-based plant materials are biocompatible, free of side effects, biodegradable, and economic. Therefore, in order to maintain the drug releases from the matrix system, Aegle marmelos fruit gum as a natural polymer and HPMC grade (K100M) as a synthetic polymer were used in the formulation of the linezolid matrix tablet. The formulation of sustained-release matrix tablets included the wet granulation technique. The formulated matrix tablets were evaluated in terms of weight variation, hardness, diameter, physical appearance, friability, thickness, and in vitro drug release. Each formulation’s matrix tablet passed the required physical assessment tests. The formulation analyses of the tablets’ dissolution showed sustained releases of drugs for up to 10–12 hours. Additionally, several polymer combinations and fillers were used to improve drug release factors using the 32 factorial design approach, drug release kinetics were optimized, and the antibacterial study was evaluated.
Ways to increase the efficiency of development in offshore fields
Authors: Suleymanova V.M. , Heydarli S.O. , Cabizada N.İ. , Akhundova K.R.
Published: March 2023

The article discusses the analysis and completion of the current state of development of high-viscosity oil fields in the offshore field of Azerbaijan. Studies show that in addition to the use of thermal methods to effectively develop such fields, it is advisable to use the technology of drilling horizontal wells in order to involve several isolated areas in development at the same time.
Исследование физико-химических свойств совмещенных лакокрасочных материалов
Authors: Цой Ю.И. , Блинов А.К.
Published: March 2023

Изучены физико-химические свойства совмещенного алкидно-уретанового лака «Лак Паркетный полуматовый » и грунтовочного состава « Валтти - Похъюсте» при модификации их поверхностно-активным веществом ПМС-10000.Установлено изменение косинуса краевого угла смачивания ,критического поверхностного натяжения и величины работы адгезии на разных породах древесины твердых лиственных пород. Использование полученных результатов исследований позволит получать защитно-декоративные покрытия древесины более высокого качества.
Эволюция взглядов на категорию лингвистической вежливости
Authors: Ладонина Н.А.
Published: March 2023

Статья посвящена обзору некоторых подходов к определению лингвистической вежливости. За несколько десятилетий существования теории лингвистической вежливости было опубликовано множество работ, посвященных самым различным аспектам данной категории. И, несмотря на тот факт, что уже не раз исследовались различные параметры речевого поведения, лингвокультурные нормы и традиции многих языковых сообществ подвергались сравнительному анализу, пока не существует общепризнанного определения и единого взгляда на лингвистическую теорию вежливости, что объясняет актуальность предпринятого анализа эволюции взглядов на данный феномен. Автор обращается к работам таких известных исследователей как П. Браун, С. Левинсон, Г. П. Грайс, Р. Лакофф, Р. Селл, Дж. Лич, Б. Фрейзер, В. Нолен, Р. Дж. Уотс и др.
Организация процесса производства в условиях цифровой экономики
Authors: Плис С.А. , Идигова Л.М.
Published: March 2023

В статье изучены вопросы цифровой трансформации процесса производства в современных условиях. В данной сделан вывод, что производственный процесс на предприятиях, не смотря на использование цифровых инструментов, все еще весьма сложен. К основным особенностям относят то, что процесс производства является пожаро- и взрывоопасным и проходит в закрытых системах с непродолжительными операциями, а конечный продукт получается путем смешивания различного сырья и мн. др.
Роль и значение социально-психологического климата компании в успешности ее функционирования
Authors: Чажаев М.И. , Идигова Л.М.
Published: March 2023

В статье анализируется роль и значение социально-психологического климата в компании и его влияние на эффективность деятельности. Этому явлению, как правило, во многих случаях, не уделяется должное внимание со стороны менеджеров организаций. В рабочем коллективе могут сформироваться как доброжелательные, так и не недоброжелательные взаимоотношения. В статье сделан вывод, что образование доброжелательного климата в организации требует больших усилий не только от административно-управленческого персонала компаний, но и от рядовых сотрудников
Особенности развития коммуникативных навыков письменной речи на английском языке у курсантов Омской академии МВД России
Authors: Васенева Н.В. , Галкина В.В.
Published: March 2023

В настоящей статье рассматривается методика обучения коммуникативным навыкам письменной речи на английском языке курсантов Омской академии МВД России. Владение английской письменной деловой речью очень актуально для любого специалиста правопорядка. Это обусловлено укреплением и расширением международного сотрудничества в правоохранительной сфере, в первую очередь в борьбе с преступностью. Автор статьи подчеркивает, что курсантам необходимо освоить как жанры академического письма, так и профессионально-ориентированные жанры. В статье представлен комплекс упражнений по развитию и совершенствованию коммуникативных навыков письменной речи на английском языке.
Integrating Gamification into Middle School Mathematics Curriculum: Game-Based Learning Approach in Namibia
Authors: Pangeiko Nautwima Johanna , Romeo Asa Asa , Panduleni Nendongo Victor
Published: March 2023

The urge to integrate gamification into the traditional curriculum as a new educational technology tool has garnered widespread popularity throughout the years. In that light, unknown is the degree to which Namibia can adopt game-based learning in its educational system, precisely the middle schools. Consequently, the purpose of this study was to ascertain the perceptions of learners and teachers toward the effective integration of gamification into the mathematics curriculum for middle school learners in Windhoek, Namibia. Grounded in the pragmatism philosophy, the study adopted a mixed research method in which quantitative data were obtained from 876 learners in middle school grades while qualitative data were acquired from 29 mathematics teachers using questionnaires with close-ended and open-ended questions, respectively. To dive into the phenomenon, the study analyzed quantitative data using structural equation modeling in the LISREL program, while qualitative data were analyzed using coding and reflexive thematic analysis with direct quotations in ATLAS.ti software. Based on the findings, learners and teachers in Windhoek expressed positive perceptions of integrating gamification into the middle school mathematics curriculum. However, the study also reveals the possibilities of gamifying the mathematics curriculum to be merely effective at the first stage of implementation, but other subjects are at stake, and not inclusive-friendly to learners from previously disadvantaged backgrounds, as emerged from the qualitative aspect of the study. Thus, the research calls for cohesive support in terms of financial support, non-financial support, and human capital support from the private sector, government, and international organizations to ensure the effective integration of gamification without jeopardizing other subjects and the inclusivity of vulnerable learners and those in remote areas.
The Former Gestapo Headquarters and the Provincial Office of Public Security in Anstadt Avenue in Łódź Interdisciplinary Site Research
Authors: Ławrynowicz Olgierd , Krupa-Ławrynowicz Aleksandra , Sowińska-Heim Julia , Latocha Krzysztof , Ossowski Artur , Gręzak Anna
Published: March 2023

The paper discusses the research me­thods and the most important results of the interdisciplinary project “The Former Gestapo Headquarters and the Provincial Office of Public Security in Anstadt Avenue in Łódź. Interdisciplinary Site Research” conducted in 2019–2021. Considering the challenges faced by the archaeology of the contemporary past, a subdiscipline of archaeology, an attempt was made to link the results of archaeological research to the relatively well-known historical context of structural and functional transformations of the site explored, mostly the establishment of a Jewish school in Anstadt Avenue at the end of the 1930s, the operation of the Gestapo headquarters during the Second World War and of the communist Provincial Office of Public Security after the war, and the division of the site into police and school sections in 1957, which has been preserved to date. Also ethno­graphic research was carried out, which identified sources referring to the forms of remembrance and commemoration of places, events, and people. The Authors hope that the archaeological research will be soon resumed on account of the planned investments, allowing to publish a complementary and interdisciplinary monograph of the site explored.
Historia de la Contabilidad Pública en el Perú
Authors: Márquez Farfán Yorllelina
Published: March 2023

El artículo no presenta resumen.
Niveles de posicionamiento de marca a nivel internacional
Authors: Lazo Luis
Published: March 2023

El artículo no presenta resumen.
Buen gobierno, gestión del riesgo y auditoría
Authors: Torres Dante
Published: March 2023

El artículo no presenta resumen.
Control de pérdidas en las empresas
Authors: Marín Graciela
Published: March 2023

El artículo no presenta resumen.
Reflexiones sobre el ámbito material del Impuesto Temporal a los Activos Netos
Authors: Durán Rojo Luis
Published: March 2023

El artículo no presenta resumen.
Coherencia y consistencia en la evaluación de proyectos: impacto del valor de desecho sobre otras variables
Authors: Sapag Chain Nassir
Published: March 2023

El artículo no presenta resumen.
Análisis financiero de prepagos de la deuda pública.
Authors: Huaman Aguilar Ricardo , Sal y Rosas Muñoz Marco Antonio
Published: March 2023

Este artículo no presenta resumen.
La empresa: actor protagónico en la gestión ambiental.
Authors: Hamann Pastorino Antonieta Magdalena Sofía
Published: March 2023

Este artículo no presenta resumen.
Miguel Ángel Martín Mato. Mercado de capitales. Thomson, 2007, 256 p.
Authors: Díaz Becerra Óscar
Published: March 2023

Esta reseña no presenta resumen.
Metodologías de valorización de instrumentos de deuda: bonos
Authors: Quintana Meza Aldo
Published: March 2023

El artículo presenta las cuatro metodologías de valorización de instrumentos de deuda o bonos. Se pone énfasis en el uso de la curva cupón cero para determinar el valor de un bono, resaltando sus ventajas comparando con otras metodologías, así como los casos cuando no se dispone de información de precios o tasas de mercado.