bluuebunny/crossref_metadata_2025 huggingface dataset:
Bathyal octopus, Muusoctopus leioderma, living in a world of acid: First recordings of routine metabolic rate and critical oxygen partial pressures of a deep water species under elevated pCO2
Authors: Trueblood Lloyd A. , Onthank Kirt , Bos Noah , Buller Lucas , Coast Arianna , Covrig Michael , Edwards Ethan , Fratianni Stefano , Gano Matthew , Iwakoshi Nathaniel , Kim Eden , Moss Kyle , Personius Chantel , Reynoso Stephanie , Springbett Cheyne
Published: December 2022

Elevated atmospheric CO2 as a result of human activity is dissolving into the world’s oceans, driving a drop in pH, and making them more acidic. Here we present the first data on the impacts of ocean acidification on a bathyal species of octopus Muusoctopus leioderma. A recent discovery of a shallow living population in the Salish Sea, Washington United States allowed collection via SCUBA and maintenance in the lab. We exposed individual Muusoctopus leioderma to elevated CO2 pressure (pCO2) for 1 day and 7 days, measuring their routine metabolic rate (RMR), critical partial pressure (Pcrit), and oxygen supply capacity (α). At the time of this writing, we believe this is the first aerobic metabolic data recorded for a member of Muusoctopus. Our results showed that there was no change in either RMR, Pcrit or α at 1800 µatm compared to the 1,000 µatm of the habitat where this population was collected. The ability to maintain aerobic physiology at these relatively high levels is discussed and considered against phylogeny and life history.
Evolutionary analyses and expression patterns of TCP genes in Ranunculales
Authors: Damerval Catherine , Claudot Carmine , Le Guilloux Martine , Conde e Silva Natalia , Brunaud Véronique , Soubigou-Taconnat Ludivine , Caius José , Delannoy Etienne , Nadot Sophie , Jabbour Florian , Deveaux Yves
Published: December 2022

TCP transcription factors play a role in a large number of developmental processes and are at the crossroads of numerous hormonal biosynthetic and signaling pathways. The complete repertoire of TCP genes has already been characterized in several plant species, but not in any species of early diverging eudicots. We focused on the order Ranunculales because of its phylogenetic position as sister group to all other eudicots and its important morphological diversity. Results show that all the TCP genes expressed in the floral transcriptome of Nigella damascena (Ranunculaceae) are the orthologs of the TCP genes previously identified from the fully sequenced genome of Aquilegia coerulea. Phylogenetic analyses combined with the identification of conserved amino acid motifs suggest that six paralogous genes of class I TCP transcription factors were present in the common ancestor of angiosperms. We highlight independent duplications in core eudicots and Ranunculales within the class I and class II subfamilies, resulting in different numbers of paralogs within the main subclasses of TCP genes. This has most probably major consequences on the functional diversification of these genes in different plant clades. The expression patterns of TCP genes in Nigella damascena were consistent with the general suggestion that CIN and class I TCP genes may have redundant roles or take part in same pathways, while CYC/TB1 genes have more specific actions. Our findings open the way for future studies at the tissue level, and for investigating redundancy and subfunctionalisation in TCP genes and their role in the evolution of morphological novelties.
Identification of QTL underlying the main stem related traits in a doubled haploid barley population
Authors: Zhang Anyong , Zhao Ting , Hu Xue , Zhou Yu , An Yue , Pei Haiyi , Sun Dongfa , Sun Genlou , Li Chengdao , Ren Xifeng
Published: December 2022

Lodging reduces grain yield in cereal crops. The height, diameter and strength of stem are crucial for lodging resistance, grain yield, and photosynthate transport in barley. Understanding the genetic basis of stem benefits barley breeding. Here, we evaluated 13 stem related traits after 28 days of heading in a barley DH population in two consecutive years. Significant phenotypic correlations between lodging index (LI) and other stem traits were observed. Three mapping methods using the experimental data and the BLUP data, detected 27 stable and major QTLs, and 22 QTL clustered regions. Many QTLs were consistent with previously reported traits for grain filling rate, internodes, panicle and lodging resistance. Further, candidate genes were predicted for stable and major QTLs and were associated with plant development and adverse stress in the transition from vegetative stage to reproductive stage. This study provided potential genetic basis and new information for exploring barley stem morphology, and laid a foundation for map-based cloning and further fine mapping of these QTLs.
Stakeholder perceptions and public health system performance evaluation: Evidence from Greece during the COVID-19 pandemic
Authors: Karokis-Mavrikos Vassilis , Mavrikou Maria , Yfantopoulos John
Published: December 2022

The COVID-19 pandemic has been challenging and testing of public health systems across the globe, engaging them in a prolonged scrutinization of their functions, capacity and resources. While in theory, this process can yield invaluable insights for future policy design and mitigate future adversity, it demands a suitable mode of evaluation. Often, innovative and ambitious legislative frames are a far cry from policymaking realities plagued with institutional and operational deficiencies. As a result, we decide to move past assessments of the de jure status quo and examine the de facto modus operandi through the eyes of the systems' participating agents. We focus on the case of Greece, a country which boasts a modern public health systemic design, aligned with contemporary public health thought and international trends. We develop a new framework iteration for public health system performance evaluation, founded on prominent templates. We rely on elite surveying insights from 261 public health policy stakeholders in Greece, collected between 15.07.2020 and 13.12.2020. We capture the effect of the COVID-19 pandemic both in a latent fashion, through the timing of our survey, and in a direct one, through explicit inquiry. Our results show that the functions of the Greek Public Health System are disproportionally developed, relevant resources come to be narrow in scope and outcomes are suboptimal, failing to fulfill identified aims. Moreover, high centralization, the absence of public health expertise and undeveloped evaluative channels prevent failures from instigating adjustments. The COVID-19 pandemic has brought the system's deficiencies to light forcefully and highlighted the essentiality of scientific inputs. Our conclusions point to an ill-alignment between the system's mission and the ideational orientation of its stakeholders, which is likely to contain structural change if it remains unaddressed. We identify future research agendas and present policy directions for the Greek public health system.
Psychometric properties and construct validity of the Parkinson’s Disease-Cognitive Rating Scale (PD-CRS) in Colombia
Authors: Clavijo-Moran Hugo Juan Camilo , Álvarez-García Daniela , Pinilla-Monsalve Gabriel D. , Muñoz-Ospina Beatriz , Orozco Jorge
Published: December 2022

Background

Cognitive impairment is frequent among people living with Parkinson’s disease: up to 40% of patients exhibit symptoms of mild cognitive impairment and 25% meet the criteria for dementia. Parkinson’s Disease Cognitive Rating Scale (PD-CRS) is one of the recommended scales by the Movement Disorders Society Task Force for level 1 screening of dementia. However, its psychometric properties have not been studied in the Colombian population.

Methods

A cross-sectional study was conducted on 100 patients with Parkinson’s disease diagnosed by a movement disorders neurologist. Patients were evaluated with PD-CRS and MoCA. Principal component analysis was conducted, and then confirmatory factor analysis was implemented through the maximum-likelihood method. Internal consistency was evaluated using Cronbach α. Convergent and divergent validity were also calculated and concurrent validity with the MoCA was assessed.

Results

62% were males. Their median age was 68 years (IQR 57–74) and the median disease duration was 4 years (IQR 2–9). 77% were classified in early stages (Hoehn and Yahr stage ≤ 2), while the MDS-UPDRS part III score was 25 (IQR 15.5–38). In the principal component factor analysis, the pattern matrix unveiled a mnesic and a non-mnesic domain. Confirmatory factor analysis showed similar explanatory capacity (λ ≥ 0.50) for items other than naming (λ = 0.34). Cronbach’s α for the full 9-items instrument was 0.74. MoCA and PD-CRS total scores were correlated (ρ = 0.71, p = 0.000). Assuming a cut-off score of 62 points, there is an agreement of 89% with the definition of dementia by MoCA for Colombia (κ = 0.59; p = 0.000).

Conclusion

PD-CRS has acceptable psychometric properties for the Colombian population and has significant correlation and agreement with a validated scale (MoCA).
Pragmatic functions of evidentiality in diplomatic discourse: Toward a new analytical framework
Authors: Xu Zhongyi
Published: December 2022

This paper examines the pragmatic functions of evidentiality categories in diplomatic discourse by illustrating a new classification of English evidentiality. It adopts a data-based approach by analyzing a corpus of thirty English political speeches from three US presidents (including Bush, Obama, and Trump). The results show that: (i) Evidentiality can be classified into three categories: personal sources; shared sources and other sources. (ii) Besides the function of (de)legitimation, evidentiality can also be used to normalize the speaker’s ideology. (iii) Shared sources of evidentials reflect the speaker’s ideological bias, because they encode the speaker’s presupposition of authority, facts, or shared knowledge. (iv) Personal sources of evidentials mean that the speaker is more willing to take verbal responsibility. (v) Other sources of evidentials reflect the speaker’s lower responsibility for the information he/she offered. (vi) The use of the three evidential sources reflects the speakers’ different responsibilities for their propositions and reveals their subjective or intersubjective stance.
Organization measures in the Enhanced Baking Tray Task
Authors: Argiuolo Antonietta , Somma Federica , Bartolomeo Paolo , Gigliotta Onofrio , Ponticorvo Michela
Published: December 2022

Introduction

The ecological assessment and the analysis of spatial organization behaviors, like the organization of objects in an empty space, in clinical and neurotypical conditions, is crucial. The Enhanced-Baking Tray Task (E-BTT) is as simple as that – placing objects inside a frame as evenly as possible, as if they were “cookies” to be baked in the oven. The E-BTT is the enhanced version of a task for neglect assessment, the Baking Tray Task, and has the advantage to register the coordinates of each object and their temporal order, meaning that it is easy to reconstruct the sequence of their placement. This sequence could be further analyzed, and, in this paper, we aim to do that with a series of indexes. Moreover, since they investigate the visual search organization of the sequence itself, their validity will be tested with a convergent measure of subjective organization.

Methods

Therefore, we asked 100 observers (76 women) to evaluate the subjective organization of each of 97 E-BTT plots, on a scale that ranged from 0 = not at all to 100 = well organized.

Results

A multiple regression model showed a significant association between subjective organization ratings (dependent variable) and Intersection rate, Total time of performance and distance to both optimal sequences (independent variables).

Discussion

Therefore the above-mentioned indexes can be considered measures of the overall organization in the E-BTT.
Memory matching features bias the ensemble perception of facial identity
Authors: Pan Tingting , Zheng Zheng , Li Feiming , Wang Jun
Published: December 2022

Introduction

Humans have the ability to efficiently extract summary statistics (i.e., mean) from a group of similar objects, referred to as ensemble coding. Recent studies have demonstrated that ensemble perception of simple objects is modulated by the visual working memory (VWM) task through matching features in VWM. However, few studies have examined the extending scope of such a matching feature effect and the influence of the organization mode (i.e., the way of combining memory matching features with ensemble properties) on this effect. Two experiments were done to explore these questions.

Methods

We used a dual-task paradigm for both experiments, which included a VWM task and a mean estimation task. Participants were required to adjust a test face to the mean identity face and report whether the irregular objects in a memory probe were identical or different to the studied objects. In Experiment 1, using identity faces as ensemble stimuli, we compared participants’ performances in trials where a subset color matched that of the studied objects to those of trials without color-matching subsets. In Experiment 2, we combined memory matching colors with ensemble properties in common region cues and compared the effect with that of Experiment 1.

Results

Results of Experiments 1 and 2 showed an effect of the VWM task on high-level ensemble perception that was similar to previous studies using a low-level averaging task. However, the combined analysis of Experiments 1 and 2 revealed that memory matching features had less influence on mean estimations when matching features and ensemble properties combined in the common region than when combined as parts of a complete unit.

Conclusion

These findings suggest that the impact of memory matching features is not limited by the level of stimulus feature, but can be impacted by the organization between matching features and ensemble target properties.
Involvement of the sensorimotor system in less advanced L2 processing: Evidence from a semantic category decision task
Authors: Bai Yating , He Wenguang
Published: December 2022

There is increasing evidence indicating that the sensorimotor system is involved in advanced L2 processing, which raises the question of what role sensorimotor information plays in the course of less advanced L2 comprehension. In the current study, two experiments were conducted using a lexical decision task (LDT) and semantic category task (SCT). The results showed that, in the LDT, a task more likely to result in participants making judgments based on the physical properties of words (e.g., familiarity, orthography), “up” words (e.g., sun, plane) did not result in faster upward than downward responses, and “down” words (e.g., tunnel, cave) also did not result in faster downward than upward responses. In the SCT, compatibility effects were found; specifically, searching for the up target after “up” words was faster than after “down” words and searching for the bottom target after “down” words was faster than after “upward-pointing” words. Hence, we concluded that L2 sensorimotor association, at least for L2 with low proficiency, not automatic in nature and is dependent upon deeper semantic task demands.
COVID-19 related stress during and one year after the first wave of the pandemic outbreak in China: The role of social support and perceptions of the pandemic
Authors: Hu Jingchu , Liu Jiayu , Huang Yiting , Zheng Zhiying , Yang Dongliang , Zhou Yunfei , Wang Jianhong
Published: December 2022

Introduction

COVID-19 related stress might vary with the pandemic changes, as well as other associated factors. This study aimed to compare the stress level during the first wave of the pandemic outbreak and 1 year later in China, and to explore the differential roles of social support and perceptions of this disease in affecting pandemic-related stress over time.

Methods

COVID-19 related stress, social support, and perceptions of the pandemic (perceived threat, perceived protection, and perceived controllability) were measured using the Impact of Event Scale-Revised for COVID-19, the Multidimensional Scale of Perceived Social Support, and the Self-Compiled Scale of COVID-19 Related Perception, respectively. Using an online survey, two independent samples were collected during the first wave of the COVID-19 outbreak (Time 1: March 2020, N = 430) and 1 year later (Time 2: April 2021, N = 512).

Results

Levels of COVID-19 related stress and social support were lower at Time 2. Furthermore, at both Time 1 and Time 2, more social support was associated with less stress. Perceived protection and controllability of COVID-19 also mediated the relationship between social support and COVID-19 at both time points. However, the perceived threat of COVID-19 only served as a mediator at Time 1.

Conclusion

These results indicate that Chinese people might experience lower COVID-19 related stress as the pandemic progresses. The perceived threat of COVID-19 played a more critical role in stress experienced at Time 1. These findings not only underscore the importance of social support under the context of Chinese society, but also have implications for developing specific interventions targeting different perceptions of COVID-19 to reduce pandemic-related stress during the different waves of this pandemic.
Patient with bipolar I disorder who presented with low blood lithium levels after receiving crushed tablets via a nasogastric tube: A case report
Authors: Fujikawa Ryoko , Fujii Kumiko , Ozeki Yuji
Published: December 2022

In clinical psychiatric cases, the placement of a nasogastric tube is occasionally considered. If a patient who presents with mania or other psychiatric conditions refuses to take drugs, they are administered via the nasogastric tube. The tablet is crushed, suspended, passed via the nasogastric line, and reaches the stomach directly. However, the effects of these processes on blood drug concentrations remain unclear. Herein, we report a patient with bipolar I disorder who presented with low blood lithium carbonate (Li) concentrations after receiving the drug via the nasogastric tube.

Case

A 26-year-old woman developed manic symptoms with grandeur delusion. She was admitted to a psychiatric hospital three times after diagnosis. Her manic symptoms with delusion improved with Li and aripiprazole (ARP). Her condition stabilized with Li 800 mg/day and ARP 9 mg/day. After the Li dose was reduced to 600 mg/day, she maintained remission, with the blood level range of Li being 0.31 ∼ 0.42 mEq/L. After 1 year, she was admitted to our hospital due to a jaw deformity. During the perioperative period, treatment with oral Li was discontinued by the surgeons, and her manic symptoms recurred. During therapy with olanzapine 20 mg and Li 800 mg, her blood Li concentration was 0.67 mEq/L. The symptoms remained. Hence, the Li dose increased to 1,000 mg/day. However, she refused to take the medication. Thus, a nasogastric tube was used to administer medicines. Thereafter, the blood Li concentration decreased to 0.43 mEq/L, which was lesser than 800 mg/day. Each blood sample was collected approximately 18 h after the administration. Her symptoms remained. Thereafter, she agreed to take the medication, and the Li concentration reached 0.78 mEq/L. Then, the symptoms partly improved.

Conclusion

After the administration of Li via the nasogastric tube, the Li concentration decreased, which was lower than expected. This phenomenon could be attributed to the fact that the medication was crushed, suspended, and administered via the nasogastric tube. Therefore, pulverizing and administering Li tablets via the nasogastric tube can be applied for the management of mania, however, caution should be observed because of the risk of fluctuations in blood Li levels, as in this case.
Resting state electroencephalography microstates in autism spectrum disorder: A mini-review
Authors: Das Sushmit , Zomorrodi Reza , Enticott Peter G. , Kirkovski Melissa , Blumberger Daniel M. , Rajji Tarek K. , Desarkar Pushpal
Published: December 2022

Atypical spatial organization and temporal characteristics, found via resting state electroencephalography (EEG) microstate analysis, have been associated with psychiatric disorders but these temporal and spatial parameters are less known in autism spectrum disorder (ASD). EEG microstates reflect a short time period of stable scalp potential topography. These canonical microstates (i.e., A, B, C, and D) and more are identified by their unique topographic map, mean duration, fraction of time covered, frequency of occurrence and global explained variance percentage; a measure of how well topographical maps represent EEG data. We reviewed the current literature for resting state microstate analysis in ASD and identified eight publications. This current review indicates there is significant alterations in microstate parameters in ASD populations as compared to typically developing (TD) populations. Microstate parameters were also found to change in relation to specific cognitive processes. However, as microstate parameters are found to be changed by cognitive states, the differently acquired data (e.g., eyes closed or open) resting state EEG are likely to produce disparate results. We also review the current understanding of EEG sources of microstates and the underlying brain networks.
Detection of SARS-CoV-2 infection clusters: The useful combination of spatiotemporal clustering and genomic analyses
Authors: Choi Yangji , Ladoy Anaïs , De Ridder David , Jacot Damien , Vuilleumier Séverine , Bertelli Claire , Guessous Idris , Pillonel Trestan , Joost Stéphane , Greub Gilbert
Published: December 2022

Background

The need for effective public health surveillance systems to track virus spread for targeted interventions was highlighted during the COVID-19 pandemic. It spurred an interest in the use of spatiotemporal clustering and genomic analyses to identify high-risk areas and track the spread of the SARS-CoV-2 virus. However, these two approaches are rarely combined in surveillance systems to complement each one's limitations; spatiotemporal clustering approaches usually consider only one source of virus transmission (i.e., the residential setting) to detect case clusters, while genomic studies require significant resources and processing time that can delay decision-making. Here, we clarify the differences and possible synergies of these two approaches in the context of infectious disease surveillance systems by investigating to what extent geographically-defined clusters are confirmed as transmission clusters based on genome sequences, and how genomic-based analyses can improve the epidemiological investigations associated with spatiotemporal cluster detection.

Methods

For this purpose, we sequenced the SARS-CoV-2 genomes of 172 cases that were part of a collection of spatiotemporal clusters found in a Swiss state (Vaud) during the first epidemic wave. We subsequently examined intra-cluster genetic similarities and spatiotemporal distributions across virus genotypes.

Results

Our results suggest that the congruence between the two approaches might depend on geographic features of the area (rural/urban) and epidemic context (e.g., lockdown). We also identified two potential superspreading events that started from cases in the main urban area of the state, leading to smaller spreading events in neighboring regions, as well as a large spreading in a geographically-isolated area. These superspreading events were characterized by specific mutations assumed to originate from Mulhouse and Milan, respectively. Our analyses propose synergistic benefits of using two complementary approaches in public health surveillance, saving resources and improving surveillance efficiency.
Effect of resistance training on heart rate variability of anxious female college students
Authors: Li Ran , Yan Runsheng , Cheng Weihao , Ren Hong
Published: December 2022

Introduction

Female college students are a group with high incidence of anxiety, and anxiety will lead to the disorder of autonomic nervous system (ANS), which will adversely affect their study and life. Resistance training plays a positive role in improving anxiety, but there is little evidence on whether resistance training can improve ANS of anxious female college students. Heart rate variability (HRV) has gained widespread acceptance in assessing ANS modulation. Therefore, the objective of this study aimed to investigate the effects of resistance training on heart rate variability (HRV) in anxious female college student.

Methods

A randomized controlled study of resistance training intervention was conducted in 27 anxious female college students that assigned randomly into an intervention group (n = 14) and a control group (n = 13). The intervention group was intervened by cluster training for 8 weeks. Self-rating anxiety scale (SAS) was used. ANS is evaluated by short-term HRV. Muscle strength was assessed by 1 RM indirect method. Independent-sample t-test was used to test post-test–pre-test scores between the intervention and control groups.

Results

After the intervention, SAS score of the intervention group was significantly decreased (P < 0.05), SDNN of the intervention group was significantly increased (P < 0.05) and LF/HF was significantly decreased (P < 0.05).

Conclusion

The resistance training intervention adopted in this study significantly increased the HRV of anxious female college students and improved their autonomic nervous disorder.
Analysis of content and online public responses to media articles that raise awareness of the opt-out system of consent to organ donation in England
Authors: Faherty Georgia , Williams Lorraine , Noyes Jane , Mc Laughlin Leah , Bostock Jennifer , Mays Nicholas
Published: December 2022

Background

Preceded by a national media campaign, in May 2020, England switched to a soft opt-out system of organ donation which rests on the assumption that individuals meeting specific criteria have consented to organ donation unless they have expressed otherwise. We aimed to learn more about how the changes were communicated, how people responded and any discrepancies between key messages and how they were interpreted by the public.

Methods

Summative content analysis of 286 stories and related reader-generated comments in leading UK online news sources (April 2019 to May 2021). Further detailed thematic analysis of 21 articles with reader-generated content, complemented by thematic content analysis coding of all 286 stories.

Results

Most media coverage on both organ donation and the law change was positive, with little variation over time or between publications. The importance of organ donation, benefits of the law change, and emotive stories (often involving children) of those who had donated an organ described as “superheroes” or those who had received organs as benefiting from a “miracle” were frequently cited. In contrast, reader-generated comments were markedly more negative, for example, focusing on loss of individual freedom and lack of trust in the organ donation system. Commentators wished to be able to choose who their organs were donated to, were dismissive and blaming towards minority ethnic groups, including undermining legitimate worries about the compatibility of organ donation with religious beliefs and end of life cultural norms, understanding and acceptance of brain-stem death and systemic racism. Misinformation including use of inflammatory language was common.

Conclusion

The portrayal of donors and recipients as extraordinary is unlikely to help to normalise organ donation. Undermining legitimate concerns, in particular those from ethnic minorities, can alienate and encourage harmful misinformation in underrepresented groups. The discrepancies between the tone of the articles and the readers comments suggests a lack of trust across the public, health, policy and media outlets. Easily accessible, ongoing and tailored sources are needed to mitigate misinformation and disinformation and ensure key messages are better understood and accepted in order to realise the ambitions of soft opt-out organ donation policies.
Establishment of a teaching hospital-based dementia consultation service for rurally-based regional district general hospitals
Authors: Schott Björn H. , Voetlause Jakob Christian , Amoah Juliana Lisa , Kratzenberg Alexander , Belz Michael , Knipper Tobias , Timäus Charles , Beskow Carmen , Sweeney-Reed Catherine M. , Wiltfang Jens , Radenbach Katrin
Published: December 2022

Objective

The treatment of patients with dementia poses a considerable challenge to regional district general hospitals, particularly in rural areas. Here we report the establishment and initial evaluation of a dementia-specific consultation service provided by a teaching hospital-based Psychiatry Department to regional district general hospitals in surrounding smaller towns.

Methods

The consultation service was provided to patients with pre-existing or newly suspected dementia, who were in acute hospital care for concurrent conditions. An evaluation of 61 consultations – 49 on-site and 12 via telemedicine – was performed to assess the needs of the participating hospitals and the specific nature of the referrals to the consultation service.

Results

Suspected dementia or cognitive dysfunction was the primary reason for consultation requests (>50% of cases). Other common requests concerned suspected delirium, behavioral symptoms, and therapeutic recommendations. During the consultations, a diagnosis of dementia was reached in 52.5% of cases, with other common diagnoses including delirium and depression. Recommendations related to pharmacotherapy were given in 54.1% of consultations. Other recommendations included referral for outpatient neurological or psychiatric follow-up, further diagnostic assessment, or assessment in a memory clinic. Geriatric psychiatric inpatient treatment was recommended in only seven cases (11.5 %).

Conclusion

Our initial evaluation demonstrates the feasibility of providing a dementia-specific consultation service in rural areas. The service has the potential to reduce acute transfers to inpatient geriatric psychiatry and enables older patients with dementia or delirium to be treated locally by helping and empowering rurally-based regional hospitals to manage these problems and associated complications.
An analysis of the etiologies and economic indexes of inpatients with stage 5 chronic kidney disease in North China
Authors: Guo Shan-Shan , Gou Yan-Li , Li Jian-Dong , Zhang Hong-Fang , Huang Yang , Zheng Xi-Jie , Chen Hang , Sui Zhun
Published: December 2022

Objective

The aim of this study was to analyze the epidemiological characteristics of the causes of chronic kidney disease (CKD) stage 5 patients in North China and to investigate the economic burden of those on hemodialysis (HD) or peritoneal dialysis (PD), as well as the associated influencing factors.

Methods

General clinical information, etiological categories, and hospitalization costs for HD or PD were collected from 1,515 patients hospitalized with stage 5 CKD at the Affiliated Hospital of Hebei University from 2016 to 2018. Logistic regression analysis was used to analyze the independent influencing factors affecting patients' financial burden.

Results

The highest rate of DN was found in patients aged 70 years or older (27.0%) and the highest incidence of primary glomerulopathy was found in patients aged <50 years (24.3%). Age, type of dialysis, and type of health insurance were independent influences on the total financial burden of patients, and the results of multifactorial logistic regression analysis showed that age [OR (95% CI): 1.009 (1.002, 1.020)] and type of dialysis [OR (95% CI): 1.746 (1.149, 2.659)] would increase the total financial burden. The type of health insurance would reduce the total financial burden [OR (95% CI): 0.222 (0.108, 0.418)].

Conclusion

Chronic kidney disease, with its complex etiology and the heavy financial burden required for treatment, remains a more serious public health problem globally, and it is therefore necessary to further improve medical coverage for dialysis patients, increase management efforts, broaden pro-poor policies and increase the accessibility of medical services in low- and middle-income areas.
Direct discontinuous Galerkin method for potential magnetic field solutions
Authors: Liu XiaoJing , Feng Xueshang , Lv Jiakun , Wang Xinyi , Zhang Man
Published: December 2022

In this paper, we employ the direct discontinuous Galerkin (DDG) method for the first time to extrapolate the coronal potential magnetic field (PF) with the source surface (SS) and call the developed numerical model as the DDG-PFSS solver. In this solver, the Laplace’s equation is solved by means of the time-dependent method, i.e., introducing a pseudo-time term into the Laplace’s equation and changing the boundary value problem into the initial-boundary value problem. The steady-state solution of the initial-boundary value problem is the solution of the Laplace’s equation to be solved. This formulation facilitates the implementation of the DDG discretization. In order to validate the DDG-PFSS solver, we test a problem with the exact solution, which demonstrates the effectiveness and third-order accuracy of the solver. Then we apply it to the extrapolation for the coronal potential magnetic field. We use the integral GONG synoptic magnetogram of Carrington rotation (CR) 2060 as the boundary condition and achieve the global potential magnetic field solution by the DDG-PFSS solver. The numerical results such as the coronal holes and streamer belts derived from the DDG-PFSS solver are in good agreement with those obtained from the spherical harmonic expansion method. Also, based on the numerical magnetic field and Wang-Sheeley-Arge model, the obtained solar wind speed is found to basically capture the structures of the high- and low-speed streams observed at 1 AU. These results suggest that the DDG-PFSS solver can be seen as a contribution to the numerical methods for obtaining the global potential magnetic field solutions of the solar corona.
Pharmacokinetics and efficacy of a novel long-acting bupivacaine formulation for cornual nerve block in calves
Authors: Venkatachalam Dinakaran , Kells Nikki , Chambers Paul , Jacob Antony , Ward Neil , Singh Preet
Published: December 2022

Local anesthetics are commonly used in farm animals to provide analgesia for painful procedures but can cause adverse effects at high systemic concentrations. The pharmacokinetics and efficacy of a long-acting sucrose acetate isobutyrate (SAIB) bupivacaine formulation following cornual nerve block in calves were compared to lidocaine. Fourteen calves were randomly assigned to one of the treatment groups (i) 5% Bupivacaine-SAIB (BUP-SAIB), n = 7; or (ii) 2% lidocaine (LID), n = 7. Cornual nerve block was performed, and duration of effective analgesia was evaluated by nociceptive threshold testing using a hand-held pressure algometer. Blood samples were collected at various time points and plasma concentrations were analyzed by HPLC. Pharmacokinetic parameters were calculated using a non-compartmental model. The mechanical nociceptive thresholds showed that the novel formulation could desensitize the skin around the horn bud for 18.77 ± 8.88 h (range 8–36 h), compared to 0.79 ± 0.34 h (range 0.5–1.5 h) with lidocaine. The mean maximum plasma concentration (Cmax) of bupivacaine was 152.03 (SD 37.34) ng/mL and its Tmax was 0.39 (SD 0.13) h. The half-life of elimination was 32.79 ± 11.00 h and the rate of clearance was 0.12 ± 0.03 L h−1. No toxicity signs were seen after treatment in either group. The novel formulation produced long-lasting analgesia of several times greater duration than that produced by lidocaine. This study showed that the safety and efficacy of the SAIB formulation justifies further studies in a larger population of animals.
Tissue Engineering Applied to Skeletal Muscle: Strategies and Perspectives
Authors: Martins Ana Luisa Lopes , Giorno Luciana Pastena , Santos Arnaldo Rodrigues
Published: December 2022

Muscle tissue is formed by elongated and contractile cells with specific morphofunctional characteristics. Thus, it is divided into three basic types: smooth muscle tissue, cardiac striated muscle tissue and skeletal striated muscle tissue. The striated skeletal muscle tissue presents high plasticity, regeneration and growth capacity due to the presence of satellite cells, quiescent myoblasts that are activated in case of injury to the tissue and originate new muscle fibers when they differentiate. In more severe deficiencies or injuries there is a loss of their regenerative capacity, thus compromising the body’s functionality at different levels. Tissue engineering studies the development of biomaterials capable of stimulating the recovery of cellular activity in injured body tissues, as well as the activity of cells with muscle differentiation potential in injury repair. However, the need for three-dimensional re-assembly in a complex organization makes it difficult to mimic this tissue and fully regenerate it for the sake of precise and effective movements. Thus, this article aims to provide a narrative review of tissue engineering strategies applied to the regeneration of skeletal muscle, in a critical evaluation of research, whether aimed at injury or atrophies such as spinal muscular atrophy.
The Use of Psychotropic Medication in Pediatric Oncology for Acute Psychological and Psychiatric Problems: Balancing Risks and Benefits
Authors: Blom Johanna M. C. , Barisone Elena , Bertolotti Marina , Caprino Daniela , Cellini Monica , Clerici Carlo Alfredo , Colliva Chiara , Favara-Scacco Cinzia , Di Giuseppe Silvia , Jankovic Momcilo , Pancaldi Alessia , Pani Luca , Poggi Geraldina , Rivi Veronica , Tascedda Fabio , Torta Riccardo , Scarponi Dorella
Published: December 2022

Severe acute behavioral and emotional problems represent one of the most serious treatment-related adverse effects for children and adolescents who have cancer. The critical and severe nature of these symptoms often makes necessary the use of psychotropic drugs. A working group composed of experts in multiple disciplines had the task of creating an agreement regarding a management plan for severe acute behavioral and emotional problems (SABEPs) in children and adolescents treated for cancer. To obtain global information on the use of psychotropic drugs in pediatric oncology, the working group first developed and mailed a 15-item questionnaire to many Italian pediatric oncology centers. Overall, an evident lack of knowledge and education regarding the use of psychotropic medications for the treatment of SABEPs was found. Thus, by referring to an adapted version of the Delphi method of consensus and standard methods for the elaboration of clinical questions (PICOs), the working group elaborated evidence-based recommendations for psychotropic drugs in the pediatric oncology setting. Furthermore, based on a thorough multivariate analysis of needs and difficulties, a comprehensive management flow was developed to optimize therapeutic interventions, which allows more accurate and efficient matching of the acute needs of patients while guiding treatment options.
Data Protection, Cookie Consent, and Prices
Authors: Wein Thomas
Published: December 2022

A legislative process is currently ongoing in the European Union to supplement the 2018 General Data Protection Regulation regarding ePrivacy regulation. The supplement is intended to complete the European data protection policy in significant areas. One addition would be for service providers on the Internet, who currently obtain the consent of their users via an opt-out provision, to always provide a paid alternative without disclosing data. This procedure is essentially aimed at overcoming “cookie consent fatigue”, which can be observed in many cases. A simple economic exchange model shows that users, as data subjects, are basically faced with the choice of paying a monetary price for a service that will also preserve their privacy or using Internet services “for free” while negating data privacy preferences. The individual demand for data privacy coincides with the socially optimal demand only if there is effective competition in the markets for data and Internet services and if users are sufficiently informed. In an online laboratory experiment with students of the Leuphana University of Lueneburg, a between-subjects design was applied in which the control group only had the option to either “pay” for the use of the artificial intelligence DeepL via cookies by surrendering data or to abstain from the service altogether, with the two treatment groups additionally given the option to use DeepL in exchange for a monetary fee so that privacy was not violated. To be tested was whether the “monetary price for privacy” option better reflected users’ privacy preferences than the current cookie opt-out solution. The results show that it was much less common for DeepL to be remunerated with the disclosure of data and less common for DeepL to be waived entirely.
Determining Current Medications Usage within a Cohort of Patients in the UK—A Descriptive Retrospective Study
Authors: Alhlayl Adel S. , Alzghaibi Haitham A. , Jamal Qazi Mohammad Sajid
Published: December 2022

Swansea University’s United Kingdom (UK) Multiple Sclerosis (MS) Register is a platform that contains information on more than 17,600 people with MS living in the UK. The register has been in operation since 2011 and represents comprehensive information about people living with MS in the UK. It is considered the first register of its kind that can link information from patients to clinical data and has been established to answer different information needs about MS. Aim: To elucidate the trends in patterns of medicines currently used by people with MS in the UK MS register. Methods: This study follows an exploratory descriptive design using the UK MS register as data resource. A number of 4516 people completed the EQ-5D survey out of 8736 people who have given their consent to answer online questionnaires which represents around 52% of the register total population. Descriptive analysis and tests were performed with SPSS to address the research objectives. Results: There are several medicine names entered by people with MS in their profiles. These medicines are used either to manage MS symptoms or to treat its associated complications. Among the medicine types revealed in this study, disease modifying drugs (DMDs), muscle relaxants, and anticonvulsants are the medicine types mainly used by people with MS followed by antidepressant and antianxiety medicines. Conclusions: From the antidepressants used most widely, amitriptyline was chosen as a subject medicine for further investigation in the remaining studies of this research due to its high frequency use, the elevated depression rates discovered among people with MS who seek information on it online, and the high online content noted on websites about this medicine.
The Territory of Valle del Jerte-La Vera and Its Tourist Development (Extremadura, SW Spain)
Authors: Ríos Rodríguez Nerea , Cárdenas Alonso Gema , Nieto Masot Ana , Leco Berrocal Felipe
Published: December 2022

At the end of the 20th century, tourism was positioned as an activity capable of diversifying and reactivating the economies of rural European areas, which were experiencing problems of demographic regression and a high rate of ageing. Subsequently, with the emergence and promotion of new models of tourism consumption, the provision of rural tourism facilities has increased, as is the case in the north of Extremadura. This study analyzes, through the use of a descriptive and analytical method, the distribution of the demographic, socioeconomic and heritage variables existing in the tourist territory of the Valle del Jerte-La Vera region in order to interrelate them with the tourist supply and demand in this area. The results allow us to observe that Valle del Jerte-La Vera is promoting tourist activities, with the promotion and implementation of better lines of action for the reception of travelers, in such a way that they favor the increase in the economic income, and these factors are capable to maintain the existing population, thus facilitating the development of rural areas.
Modeling and Simulation of a Novel Low-Speed High-Torque Permanent Magnet Synchronous Motor with Asymmetric Stator Slots
Authors: Kou Shaokai , Kou Ziming , Wu Juan , Wang Yandong
Published: December 2022

Focusing on the unstable electromagnetic performance of an air gap magnetic field caused by torque ripple and harmonic interference of a multi-slot and multi-pole low-speed high-torque permanent magnet synchronous motor (LHPMSM), an asymmetric stator slot is proposed to improve the comprehensive electromagnetic performance of the motor. Moreover, this paper develops an exact analytical model which predicts the magnetic field distribution based on Laplace’s and Poisson’s equations. The stator slot asymmetry is introduced into the model and solved by the method of separating variables. Taking a 40p168s LHPMSM as an example, numerical results of the no-load flux density field distributions are obtained by the finite element method (FEM) and employed to validate the analytical model. The influence of stator slot asymmetric structure on electromagnetic characteristics is subsequently analyzed. The results show that, compared with the semi-closed slot model, the asymmetric slot has better torque characteristics, and the electromagnetic characteristics of the motor can be significantly improved by optimizing the stator slot asymmetry. Finally, a prototype is manufactured and tested to validate the theoretical analysis.
The Biosynthesized Zinc Oxide Nanoparticles’ Antiviral Activity in Combination with Pelargonium zonale Extract against the Human Corona 229E Virus
Authors: Alqahtani Abdulsalam A. , El Raey Mohamed A. , Abdelsalam Eman , Ibrahim Ammar M. , Alqahtani Omaish , Torky Zenab Aly , Attia Hany G.
Published: December 2022

Almost one-third of all infectious diseases are caused by viruses, and these diseases account for nearly 20% of all deaths globally. It is becoming increasingly clear that highly contagious viral infections pose a significant threat to global health and economy around the world. The need for innovative, affordable, and safe antiviral therapies is a must. Zinc oxide nanoparticles are novel materials of low toxicity and low cost and are known for their antiviral activity. The genus Pelargonium was previously reported for its antiviral and antimicrobial activity. In this work, Pelargonium zonale leaf extract chemical profile was studied via high-performance liquid chromatography (HPLC) and was used for the biosynthesis of zinc oxide nanoparticles. Furthermore, the antiviral activity of the combination of P. zonale extract and the biosynthesized nanoparticles of ZnO against the human corona 229E virus was investigated. Results revealed that ZnONPs had been biosynthesized with an average particle size of about 5.5 nm and characterized with UV, FTIR, TEM, XRD, and SEM. The antiviral activity showed significant activity and differences among the tested samples in favor of the combination of P. zonale extract and ZnONPs (ZnONPs/Ex). The lowest IC50, 2.028 µg/mL, and the highest SI, 68.4 of ZnONPs/Ex, assert the highest antiviral activity of the combination against human coronavirus (229E).