Biomarker Testing Disparities in Metastatic Colorectal Cancer
Authors: Sabbagh Saad , Herrán María , Hijazi Ali , Jabbal Iktej Singh , Mohanna Mohamed , Dominguez Barbara , Itani Mira , Sarna Kaylee , Liang Hong , Nahleh Zeina , Wexner Steven D. , Nagarajan Arun 
Published: July 2024

Importance

Among patients with metastatic colorectal cancer (mCRC), data are limited on disparate biomarker testing and its association with clinical outcomes on a national scale.

Objective

To evaluate the socioeconomic and demographic inequities in microsatellite instability (MSI) and KRAS biomarker testing among patients with mCRC and to explore the association of testing with overall survival (OS).

Design, Setting, and Participants

This cohort study, conducted between November 2022 and March 2024, included patients who were diagnosed with mCRC between January 1, 2010, and December 31, 2017. The study obtained data from the National Cancer Database, a hospital-based cancer registry in the US. Patients with mCRC and available information on biomarker testing were included. Patients were classified based on whether they completed or did not complete MSI or KRAS tests.

Exposure

Demographic and socioeconomic factors, such as age, race, ethnicity, educational level in area of residence, median household income, insurance type, area of residence, facility type, and facility location were evaluated.

Main Outcomes and Measures

The main outcomes were MSI and KRAS testing between the date of diagnosis and the date of first-course therapy. Univariable and multivariable logistic regressions were used to identify the relevant factors in MSI and KRAS testing. The OS outcomes were also evaluated.

Results

Among the 41 061 patients included (22 362 males [54.5%]; mean [SD] age, 62.3 [10.1] years; 17.3% identified as Black individuals, 78.0% as White individuals, 4.7% as individuals of other race, with 6.5% Hispanic or 93.5% non-Hispanic ethnicity), 28.8% underwent KRAS testing and 43.7% received MSI testing. A significant proportion of patients had Medicare insurance (43.6%), received treatment at a comprehensive community cancer program (40.5%), and lived in an area with lower educational level (51.3%). Factors associated with a lower likelihood of MSI testing included age of 70 to 79 years (relative risk [RR], 0.70; 95% CI, 0.66-0.74; P &amp;lt; .001), treatment at a community cancer program (RR, 0.74; 95% CI, 0.70-0.79; P &amp;lt; .001), rural residency (RR, 0.80; 95% CI, 0.69-0.92; P &amp;lt; .001), lower educational level in area of residence (RR, 0.84; 95% CI, 0.79-0.89; P &amp;lt; .001), and treatment at East South Central facilities (RR, 0.67; 95% CI, 0.61-0.73; P &amp;lt; .001). Similar patterns were observed for KRAS testing. Survival analysis showed modest OS improvement in patients with MSI testing (hazard ratio, 0.93; 95% CI, 0.91-0.96; P &amp;lt; .001). The median (IQR) follow-up time for the survival analysis was 13.96 (3.71-29.34) months.

Conclusions and Relevance

This cohort study of patients with mCRC found that older age, community-setting treatment, lower educational level in area of residence, and treatment at East South Central facilities were associated with a reduced likelihood of MSI and KRAS testing. Highlighting the sociodemographic-based disparities in biomarker testing can inform the development of strategies that promote equity in cancer care and improve outcomes for underserved populations.