bluuebunny/crossref_metadata_2025 huggingface dataset:
Bot “PET descomplica”: ferramenta com inteligência artificial para orientação acadêmica
Authors: De Melo Silva Mariana , Correia de Oliveira Luan , Marina Costa Nascimento Bianca , Lins Leite Elizabeth , Vieira Silva Evilasio , Vitoria Batista Cardoso Estephany , Frutuoso da Silva Anthony , De Souza Oliveira Lucimere , Shirley de Lima Santos Rayssa , Da Silva Soares Pollyanna , Tulio Dos Santos Silva Adailson , Bruno Malaquias José , Duarte Pereira Daniel
Published: February 2025

Bots, ou robôs digitais, são ferramentas úteis, cada vez mais presentes no ambiente acadêmico, auxiliando discentes e docentes com serviços e esclarecimentos. No Centro de Ciências Agrárias da UFPB, em Areia, foi criado o “PET Descomplica”, uma parceria entre o PET AgroBio e o Laboratório de Entomologia, com o objetivo de orientar sobre serviços essenciais do campus. O chatbot superou as expectativas, oferecendo respostas rápidas e recebendo uma média de 4 (escala Likert 1-5). Avaliações indicaram 41% como ótimo, 33,33% bom, 16,66% razoável e 8,33% insatisfatório, confirmando sua eficiência, proximidade e satisfação no suporte.
Povos indígenas e a psicologia do bem viver
Authors: Lima de Souza Apurinã Ketlen , Ruy do Nascimento Xokó José , Andreia Nicolli Aline
Published: February 2025

O trabalho relata a experiência do Curso de Extensão Uma imersão multidisciplinar na história e na cultura dos povos indígenas, realizado entre novembro de 2022 e janeiro de 2023, pela UFAC, no âmbito do PET Conexões de Saberes: Comunidades Indígenas. O último encontro abordou “Os Povos Indígenas e a Psicologia do Bem Viver”, com base em autores como Ailton Krenak e Alberto Acosta. O curso oportunizou reflexões sobre o “Bem Viver” como combate às desigualdades e como preservação das memórias e histórias indígenas.
Momento “como vai você?”
Authors: Mary Oliveira de Souza Ana , Ribeiro de Oliveira Fabio , Ribeiro de Oliveira Fabio
Published: February 2025

Este trabalho investiga a importância e a efetividade do momento de escuta terapêutica “Como vai você?” no grupo PET de Engenharia Sanitária e Ambiental da Universidade Federal da Bahia. A metodologia envolveu um questionário semiestruturado aplicado a doze integrantes ou egressos do grupo. Os resultados indicam que esse momento proporciona leveza, reflexão e acolhimento, além de ser reconhecido como espaço de confiança e descarga emocional, onde conflitos podem ser discutidos de maneira segura.
Uso de experimentos demonstrativos em sala de aula como forma de aplicação de metodologia de aprendizagem ativa
Authors: Nunes Ribeiro Beatriz , Vieira da Silva Lorenza , Vicente Hallak Dangelo José
Published: February 2025

As Diretrizes Curriculares de 2019 incentivam metodologias de aprendizagem ativa em Engenharia. Este trabalho apresenta dois experimentos, desenvolvidos pelo Grupo PET-EQ da Unicamp, que integram teoria e prática em sala de aula, reforçando conceitos teóricos e promovendo uma experiência enriquecedora. Os experimentos estão sendo aplicados no novo currículo de Engenharia Química da Unicamp, implementado em 2023, que foca no desenvolvimento de competências e habilidades dos alunos.
Lutas e movimentos dos povos indígenas no brasil contemporâneo
Authors: Severino da Silva Filho Manchineri Elcio , Batista da Silva Manchineri Francisco , Andréia Nicolli Aline
Published: February 2025

Este texto relata uma experiência do Grupo PET Conexões de Saberes: Comunidades Indígenas (Ufac) com o Neabi. Foi um curso de extensão, "Uma imersão multidisciplinar na história e cultura dos povos indígenas", realizado entre novembro de 2022 e janeiro de 2023, em 12 encontros. Um deles, sobre “Lutas e Movimentos dos Povos Indígenas no Brasil Contemporâneo”, analisou semelhanças e diferenças entre esses conceitos, destacando que as conquistas indígenas no Estado Democrático de Direito resultam de reivindicações árduas, muitas vezes marcadas por suor e sangue.
Género y caminabilidad. Estudios de caso en la ciudad de São Paulo
Authors: Kronka Mülfarth Roberta , Rabelo Albala Paula , Sato André
Published: February 2025

Caminar desempeña el papel de eje estructurador primario del paisaje. Estudios recientes resaltan la importancia de evaluar la caminabilidad desde una perspectiva de género. Mediante una evaluación ergonómica urbana, este artículo analiza la brecha en el uso del espacio entre mujeres y hombres en zonas céntricas de São Paulo. Los resultados revelan que la presencia de mujeres en las aceras se relaciona con las áreas de uso mixto y la presencia de fachadas activas. Se sugiere que las políticas de planificación urbana consideren estas especificidades para promover la equidad de género en la caminabilidad y mejorar la calidad de vida en las ciudades.
Pembrolizumab plus Pemetrexed and Platinum in Metastatic Non-Squamous Non-Small Cell Lung Cancer: A Real-Life Study at a Portuguese Centre
Authors: João Santos Maria , Ferro Filipa , Machado Andrea , Vilariça Ana Sofia , Hasmucrai Direndra , Alves Paula
Published: February 2025

First-line therapy for metastatic non-small-cell lung cancer without targetable mutations is platinum-based chemotherapy plus pembrolizumab if programmed death ligand 1 is < 50%. The aim of this real-life retrospective study is to assess the efficacy and safety of this therapy. This retrospective observational study was conducted at the Pulmonary Oncology Department in Unidade Local de Saúde Santa Maria, in Lisbon, Portugal. We included patients with stage IV non-squamous non-small-cell lung cancer with programmed death ligand 1 < 50% that started pembrolizumab plus platinum and pemetrexed between July 2020 and December 2022. Follow-up was carried out until September 2023. Progression-free survival, overall survival, response rate and safety were evaluated. Sixty-six patients were included. Median age 67 years, 72.7% male, 92.4% performance status 0 - 1, 90.9% current/former smokers. Programmed death ligand 1 < 1% in 63.6%. Median overall and progression-free survival were 12.2 months and 6.7 months, respectively. At the time of the cut-off, 21.2% of patients were alive and progression-free. The objective response rate was 42.4% (partial response). The disease control rate was 69.7%. Adverse events occurred in 92.4%, 43.9% had grade 3 - 4 adverse effects. The most common were anemia (50.0%), neutropenia (40.9%), and asthenia (36.4%). Treatment was discontinued in three patients due to adverse effects. There were no treatment-related deaths reported. With median progression-free survival and overall survival of 6.7 and 12.2 months, respectively, and no new safety signals, these results complement data from clinical trials, providing information from a real-world setting.
Advancing Towards a Targeted Surveillance Strategy in Traumatic Brain Injury
Authors: Moura Gonçalves Ví­tor
Published: February 2025

N/A
Rénovation de la gestion du saumon en Bretagne : le projet RENOSAUM
Authors: PRÉVOST Étienne , LEBOT Clément , BEAULATON Laurent , ARAGO Marie-Andrée , LEPRÉVOST Gaëlle , NEVOUX Marie , RIVOT Étienne
Published: February 2025

Pour réviser la gestion des populations de saumon en Bretagne, et plus particulièrement la régulation de leur exploitation par pêche à la ligne en rivière, l’OFB, INRAE et l’Université de Pau et Pays de l’Adour, en collaboration avec Bretagne Grands Migrateurs, ont œuvré conjointement dans le cadre d’un vaste exercice d’aide à la décision (projet RENOSAUM, 2017-2022). Ce travail est sans précédent par la quantité de données valorisées, la prise en compte des recommandations internationales et le dialogue continu entre scientifiques et acteurs de la gestion qui ont gouverné son déroulement. Il permet de disposer aujourd’hui, pour les 18 principales rivières à saumon bretonnes et sur plus de trois décennies (1987-2020), de connaissances inédites concernant l’abondance des juvéniles et des adultes, les mécanismes de renouvellement des générations au sein des populations étudiées, ainsi que leur régime d’exploitation par la pêche à la ligne. Elles ont servi de socle pour l’établissement de nouvelles limites de conservation pour chacune des populations étudiées, puis pour une analyse comparative d’un très large ensemble de scénarios de régulation de l’exploitation. Ce travail a conduit in fine à la mise en place de mesures de régulation renouvelées de l’exploitation par pêche à la ligne applicables à compter de 2023.
MAPPING THE LEVEL OF PREPAREDNESS COMMUNITY FOR EARTHQUAKE DISASTER USING SPATIAL APPROACH IN CENTRAL OF SULAWESI
Authors: Novarita Amalia , Rahmawati Rahmawati , Putra Exsa
Published: February 2025

The impact of earthquakes and floods in the Kulawi, Central  Sulawesi district informed the choice of research location. The primary feature of this research site is the general lack of community readiness for local calamities. This study aims to assess the degree of community readiness for earthquake disasters using the Spatial Approach, which provides a succinct and precise description  of the entire study. Spatially-based quantitative descriptive method. use the CVR (Content Validity Ratio) approach to assess the questionnaire's validity and the AHP (Analytical Hierarchy Process) method. The community's comprehension of the spatial approach that exists in the surrounding environment and is connected to the possibility of disaster as both a risk component and a vulnerability factor is the unresolved issue. Thus, the community needs to imitate obtaining progressively greater knowledge about disasters. Despite the most weight (25), earthquake-resistant infrastructure highlights the significance of high-quality building construction and the presence of emergency facilities to lower the danger of damage and casualties. The requirement for training and simulations to improve the community's comprehension of preparedness measures is shown by the 20-point weight assigned to mitigation and community awareness. With a weight of 20, the Early Warning System emphasises the efficiency and dissemination of information to provide the public adequate time to take action before a crisis strikes. With a weight of 15, coordination and rapid response help to speed up disaster management by fostering agency collaboration and prompt action. On the other hand, logistics readiness, which has a weight of 10, places a strong emphasis on having emergency supplies like food and water.
POLICY DIRECTIONS FLOOD DISASTER MITIGATION IN KAMPAR REGENCY, RIAU PROVINCE
Authors: Sihaini Etika , Hermon Dedi
Published: February 2025

There have been many studies on flood disaster mitigation policy directions, but they have not been widely developed in Indonesia as a tropical country with a unique rainfall pattern. This is an indicator used to assess the level of flood disaster vulnerability. Exceptionally high rainfall intensity always causes flood disaster problems in Kampar Regency. This study aims to 1) formulate the level of flood vulnerability in Kampar Regency, Riau Province, 2) analyse the characteristics of land in Kampar Regency, Riau Province, 3) formulate flood disaster mitigation policy directions by the Kampar Regency Government, Riau Province. The method used in this study is quantitative, and it is a survey and spatial analysis. This study was conducted in Kampar Regency, Riau Province. Furthermore, in processing flood disaster mitigation policy directions, the AHP (Analytical Hierarchy Process) method is used to formulate appropriate priority directions to mitigate flood disasters. Based on the results of the study, the level of flood disaster vulnerability with analysis using the GFI method, there are four flood vulnerability zones in Kampar Regency, namely: a high flood vulnerability zone covering an area of 88,658.36 ha, a moderate flood vulnerability zone covering an area of 142,821 ha, a low flood vulnerability zone covering an area of 86,357.23 ha and a flood-free zone covering an area of 715,850.97 ha. Furthermore, based on data processing through expert choice software, the direction of flood disaster mitigation policies is determined to have 9 alternatives. With these alternatives, it is hoped that they can be formulated to reduce the risk of flood disasters in Kampar Regency.
Editorial
Authors:   Associação Portuguesa de Nutrição, Borges Nuno
Published: February 2025

De entre as patologias que se encontram mais estreitamente ligadas aos hábitos alimentares de cada um, a obesidade continua a ter uma preponderância enorme na sociedade atual. Poucas são as sociedades ou grupos de indivíduos que escapam a prevalências demasiado elevadas desta condição, que sabemos estar intimamente relacionada com o risco de desenvolver outras condições clínicas como a diabetes mellitus tipo 2, a hipertensão arterial, as dislipidemias ou algumas formas de cancro, para nomear apenas algumas. O seu tratamento tem constituído um dos grandes desafios da Medicina atual, e as já referidas prevalências inaceitavelmente elevadas são o testemunho não só da nossa incapacidade de a prevenir como de a tratar. A tentativa de encontrar uma solução farmacológica para o problema não é de hoje, estando descritos na literatura ensaios clínicos com variadíssimos compostos desde pelo menos a década de 50 do séc. XX. Esse percurso foi no geral assaz frustrante, fazendo aparecer compostos que ou eram muito pouco eficazes ou, quando revelavam alguma capacidade de reduzir o peso, manifestavam um conjunto de efeitos secundários que impossibilitavam o seu uso racional.

Foi há cerca de 20 anos que surgiram no mercado os primeiros medicamentos da família dos agonistas dos recetores do glucagon-like peptide 1 (GLP1), que sendo inicialmente desenvolvidos para a diabetes mellitus tipo 2, acabaram por demonstrar uma eficácia na redução de peso desconhecida até então. A “corrida ao ouro” por parte das empresas farmacêuticas começou então, fazendo surgir no mercado outros fármacos da mesma família ainda mais eficazes, sobretudo de há cerca de cinco anos para cá. Foram entretanto aprimorados certos aspetos farmacológicos, com algumas novas moléculas a revelarem capacidade de estimular outros recetores como o do glucose-dependent insulinotropic polypeptide (GIP) ou o da glicagina, conferindo-lhes ainda maior eficácia. Podemos encontrar a descrição dos efeitos desta nova classe de medicamentos no artigo de Silva e colaboradores, que é publicado nesta edição da Acta Portuguesa de Nutrição.

Os desafios que o aparecimento destes compostos coloca são múltiplos e envolvem, necessariamente, todos os que se dedicam ao tratamento nutricional e alimentar destes doentes. Dado o ainda reduzido tempo que estes medicamentos têm no mercado, existe ainda algum desconhecimento sobre a melhor forma de atuar sob o ponto de vista nutricional, o que, na visão do investigador, propicia um conjunto muito interessante de oportunidades de investigação.

O peso da obesidade na nossa sociedade é muito elevado: o aparecimento de novas soluções, por muito interessantes que sejam, não deve, no entanto, desviar-nos da importância da prevenção como base da mitigação deste fenómeno e do papel central da alimentação.
Conhecimentos e práticas das Amas relativamente à alimentação e nutrição infantil
Authors:   Associação de Paralisia Cerebral de Guimarães, Rua N. Senhora de Fátima, Penselo, 4800-110 Guimarães, Portugal, Araújo Ana , Pinto Elisabete ,   Centro de Biotecnologia e Química Fina, Escola Superior de Biotecnologia da Universidade Católica Portuguesa, Rua Diogo Botelho, n.º 1327, 4169-005 Porto, Portugal,   EPIUnit - Unidade de Investigação em Epidemiologia, Instituto de Saúde Pública da Universidade do Porto Rua das Taipas, n.º 135, 4050-600 Porto, Portugal, Afonso Cláudia ,   EPIUnit - Unidade de Investigação em Epidemiologia, Instituto de Saúde Pública da Universidade do Porto Rua das Taipas, n.º 135, 4050-600 Porto, Portugal,   Faculdade de Ciências da Nutrição e da Alimentação da Universidade do Porto, Rua do Campo Alegre, n.º 823, 4150-180 Porto, Portugal,   Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Rua das Taipas, n.º 135, 4050-600 Porto, Portugal,   GreenUPorto, Centro de Investigação em Produção Agroalimentar Sustentável/ Inov4Agro, DGAOT, Faculdade de Ciências da Universidade do Porto, Rua da Agrária, n.º 747, 4485-646 Vairão, Portugal
Published: February 2025

A Ama, profissional responsável por assegurar cuidados básicos a crianças, passou a estar enquadrada legalmente, em Portugal, a partir do Decreto-lei n.º158/84. Este elencava requisitos e exigências para todos aqueles cujo objetivo fosse tornar a sua habitação o local de permanência de quatro crianças, entre os três meses e os três anos. Em 2022, ao abrigo da legislação que regulamenta
as condições para a concretização da gratuitidade a confeção das refeições passa a ser da responsabilidade das Amas. Com ausência de orientações específicas, sobretudo na seleção e confeção de alimentos, foi objetivo deste trabalho caracterizar atitudes, crenças, valores e práticas relativas à alimentação, perceber o nível de conhecimento e compreender os fatores associados às
escolhas alimentares por parte das Amas. Para a recolha de dados, foi utilizada metodologia qualitativa com recurso a entrevista semiestruturada, a partir de uma amostra de conveniência constituída por onze Amas. As entrevistadas, apresentaram atitudes, práticas e experiências diversificadas, fato que poderá estar relacionado com a legislação em vigor à data do seu início de atividade. Identificam como fontes privilegiadas de informação as educadoras de infância e os documentos que recebem nas formações. A aquisição dos géneros ocorre ao fim de semana e consideram os gostos das crianças, a qualidade e o preço como fatores determinantes na seleção. A confeção é feita no início ou final do dia e, na hora, aquecida. Oferecem essencialmente fruta à merenda
da manhã, o almoço inclui sopa e prato e a merenda da tarde está dependente dos alimentos enviados pelos pais. Foi percetível que estas profissionais dispõem de parca orientação e legislação, estando a organização e planeamento de refeições dependente dos seus conhecimentos e da capacidade e interesse para a pesquisa de informação.
Rastreio do risco nutricional em utentes geriátricos dependentes nos cuidados de saúde primários
Authors:   Unidade de Saúde Familiar Vale do Âncora da Unidade Local de Saúde do Alto Minho, Rua Pontault Combault, n.º 291, 4910-576 Vila Praia de Âncora, Portugal, Gonçalves Catarina Vilas Boas , Alves Nuno Figueiras ,   Unidade de Saúde Familiar Vale do Âncora da Unidade Local de Saúde do Alto Minho, Rua Pontault Combault, n.º 291, 4910-576 Vila Praia de Âncora, Portugal, Oliveira Mariana ,   Serviço de Nutrição da Unidade Local de Saúde do Alto Minho, Rua Pontault Combault, n.º 291, 4910-576 Vila Praia de Âncora, Portugal
Published: February 2025

Introdução: Segundo o estudo Nutrition UP 65, 14,8% dos idosos portugueses encontram-se em risco de desnutrição. A realização do rastreio do risco nutricional encontra-se recomendada para todos os níveis de cuidados do Serviço Nacional de Saúde, sendo a ferramenta MUST uma das ferramentas sugeridas para a identificação do risco nutricional.

Objetivos: Promover o rastreio do risco nutricional em utentes dependentes, com idade superior a 65 anos; avaliar a aplicação do rastreio nesta população; e promover e avaliar a referenciação de utentes em risco à consulta de Nutrição.

Metodologia: Estudo de melhoria contínua da qualidade. Dimensão: qualidade técnico-científica. Unidades de estudo: alvo – utentes dependentes, com idade superior a 65 anos, inscritos na Unidade de Saúde; intervenientes – médicos, enfermeiros e secretários clínicos. A fonte de dados foi o SClínico®. Foram definidos critérios de inclusão/exclusão, critérios de avaliação e padrões de qualidade. Foram realizadas avaliações inicial, intermédia (após 3 meses) e final (após 6 meses), sendo os resultados de cada avaliação apresentados em reunião de serviço. A fase de intervenção, consistiu na aplicação das medidas corretoras previamente identificadas que consistiu em formação com Nutricionista e apresentação de resultados e propostas de melhoria. Análise estatística: Microsoft Office Excel®.

Resultados: Amostra consistiu em 31 utentes com idade média 88 anos e destes 77% pertenciam ao sexo feminino. Na avaliação intermédia todos os resultados permaneceram insuficientes. Na avaliação final atingiu-se um bom padrão de qualidade na aplicação do MUST; resultado suficiente na identificação do cuidador informal; e resultados insuficientes relacionados com domicílios médicos e referenciação à consulta de Nutrição. Dos utentes avaliados, 37% estavam em risco de desnutrição e 100% das referenciações foram avaliadas por Nutricionista.

Conclusões: Mais de 1/3 dos utentes estavam em risco de desnutrição. Alcançada melhoria no padrão de qualidade da aplicação do rastreio, maior sensibilização da equipa e boa articulação com o Serviço de Nutrição. Contudo, existe potencial de melhoria dos critérios relacionados com a equipa médica e a articulação das 3 equipas, com necessidade de melhorar a organização e registos clínicos, com monitorização regular.
Substitute Heirs in Article 185 Compilation of Islamic Law Maqashid Shariah Jaser Audah Perspective
Authors: Ubaidillah Ubaidillah , Nurohman Dede , Anshor Ahmad Muhtadi , Baihaqi Wahid Ahtar , Kooria Mahmood
Published: February 2025

Abstract

Article 185 KHI was established as a reaction to the unequal distribution of inheritance by giving grandchildren the right of replacement for children. In the context of Islamic law reform in Indonesia, the Compilation of Islamic Law (KHI) proposal has sparked endless debate between pros and cons. As far as the researcher observes, the debates expressed in various discussions and research have not been able to resolve this issue, including attempts to interpret Hazairin through theory of mawali. This research aims to describe and analyze maqasid sharia Jaser Audah perspective on the provisions of successor heirs and relevance maqasid sharia Jaser Audah against the benefits found in Article 185 KHI. This research uses a qualitative type that is oriented on purpose. The results of this study show that the view maqasid sharia Jaser Audah regarding the meaning of successor heir can be seen through the following six features: 1) cognitive character: positioning the results of Zayd's ijtihad as a product of ijtihad; 2) universal features: replacement of heirs applies to all parties with consideration of egalitarian principles, distributive justice and empowerment of heirs; 3) characteristics of openness: making internal factors (customary law, family structure) and external (comparative studies and equality) in the genealogy of Article 185 as tradition; 4) hierarchical structure features: the right of succession given to grandchildren philosophically contains benefits that are oriented towards maqsad (goal) which runs simultaneously; 5) include the element of justice as a philosophical value in mediating the hadith narrated by Bukhari and the results of Zayd's ijtihad; 6) the aim of the Islamic law system: granting grandchildren rights over children is an effort to realize them purpose justice, empowerment and protection of human rights.
Mediated model development for coastal marsh management in the Chesapeake Bay
Authors: Russ Emily , Hernandez-Abrams Darixa , Herman Brook , Specht Jackie , Osorio Raul , Zito-Livingston Adrianna , Thompson Kevin , Landaverde Andrea , Swannack Todd
Published: February 2025

The purpose of this technical note is to develop a conceptual model that describes the critical processes, stressors, and interactions that affect coastal marsh dynamics within the Chesapeake Bay, as identified by subject matter experts, and then link those factors to specific management actions. Managing coastal marshes within Chesapeake Bay involves multiple stakeholders across federal, state, local, and nongovernmental agencies. Reaching consensus among large stakeholder groups can be difficult, since each has their own perspective and requirements for management. Mediated modeling is a technique that facilitates consensus building among stakeholders and provides a transparent roadmap for decision-making. This technical note describes how mediated modeling was applied to marsh management in Chesapeake Bay. On 4–5 May 2022, The Nature Conservancy (TNC) and the US Army Engineer Research and Development Center (ERDC) Integrated Ecological Modeling Team (EcoMod) partnered for a multistakeholder mediated modeling workshop to (1) build a conceptual model that depicts the relevant processes impacting marsh dynamics, and (2) identify indicators that are necessary for tracking marsh conditions, which inform needed management strategies. This conceptual model provides the foundation for the development of a marsh management decision framework that will use indicators to identify marsh conditions that subsequently trigger management decisions.
[PÓSTER] ESTUDIO COMPARATIVO DE LAS PROPIEDADES FUNCIONALES Y TECNOLÓGICAS DE DOS TIPOS DE CHLORELLA VULGARIS: GOLDEN vs GREEN
Authors: Muela Clemente Teresa
Published: February 2025

Las microalgas son organismos unicelulares autótrofos, marinos o de agua dulce, que han adquirido importancia a lo largo de los años por su elevada diversidad y potencial aplicación en la industria. Algunos de los usos más conocidos pertenecen a los sectores acuícola y agrícola, energético, cosmético y nutricional.
Las variedades de microalgas cultivadas a gran escala, y cuyo uso está permitido en alimentación, son limitadas y, en concreto, la Chlorella vulgaris está reconocida por la Autoridad Europea de Seguridad Alimentaria (EFSA) para su uso culinario (Comisión Europea, 2022)
Por su elevado contenido en proteínas de origen vegetal, así como vitaminas y minerales entre otros, son consideradas de alto valor nutritivo y con múltiples propiedades beneficiosas para la salud.
Los retos sensoriales inherentes a la incorporación de Chlorella vulgaris green en formulaciones alimentarias, debido a su alto contenido en clorofila que otorga el característico color verde y un sabor y aroma marinos, son un factor limitante para su aplicación en la industria alimentaria. Sin embargo, la Chlorella vulgaris golden, debido a su técnica de cultivo específica, carece de clorofila, lo que elimina estas barreras sensoriales y amplía las posibilidades de utilización de esta microalga en la alimentación, aportando un sabor y color más discretos con ligeras variaciones en sus beneficios nutricionales y funcionales (Barkia, Saari y Manning, 2019).
Considerando lo mencionado anteriormente, es interesante considerar las microalgas como una posible alternativa a la proteína animal, saludable y económica para ser utilizada tanto en alimentación.
[PÓSTER] Películas activas de Poli(3-hidroxibutirato-co-3-hidroxivalerato) enriquecidas con compuestos fenólicos
Authors: La Fuente Arias Carla Ivonne , González-Martínez Chelo , Chiralt Amparo
Published: February 2025

Este trabajo tiene como objetivo analizar el efecto de la catequina, el ácido ferúlico y la vainillina, incorporados al 5 % en películas de PHBV, en las propiedades funcionales y estructurales de la matriz, así como en el comportamiento térmico y grado de cristalización del polímero.
Acarous calamus L. based nano-bio formulation as an alternative to synthetic fungicides against Aspergillus flavus Link
Authors: Kanagasabai Vaishnavi , Kandiah Pakeerathan , Sashikesh Ganeshalingam
Published: February 2025

Carcinogenic Aflatoxins producing Aspergillus flavus contaminate food crops and pose health risks to humans and livestock. Synthetic fungicides are commonly used to control A. flavus, but they can have negative environmental and health impacts. Acarous calamus L., also known as sweet flag, is a plant with potential antifungal properties. Nanotechnology can enhance the effectiveness of plant extracts by increasing their surface area and allowing for better penetration. Current study focused to explore nano-bio formulation of A.calamus silver nanoparticle and comparative study of its efficacy on growth inhibition and reproduction of A. flavus. All the experiments were conducted in Complete Randomized Design (CRD), and data were subjected ANOVA using SAS 9.1 and Tukey's HSD multiple comparison test was used to determine the best treatment combination at P <0.05. The Jasco V-570 UV-VIS-NIR spectrophotometer results confirmed that the silver nanoparticle was synthesized at the optimum condition of optimum volume was found to as 25 mL of 0.01 mol L(-1) of silver nitrate, optimum time was found as 210 minutes with the absorption peak range of 400 nm - 500 nm. SEM characterization captured the AgNPs size varies from 0.11µm to 2.23µm. AgNPs concentration of 0.02 g inhibit the growth by 50% compared to A. calamus water extracts and >90% reduction in spore production reduction at . Moreover, growth inhibition percentage and rate spore production of A. flavus in Ag-Nano particle inoculated treatments were perfectly corelated with the R2 value of 0.96 at P <0.01& 0.05. This study concludes Nano-bio formulations show enhanced the efficiency and promise of plant-based solution as a natural fungicide against A. flavus. Field research is underway to fully understand the potential of this Nano-bio formulations.
Shaping the developing homunculus: the roles of deprivation and compensatory behaviour in sensory remapping
Authors: Tucciarelli Raffaele , Bird Laura , Straka Zdenek , Szymanska Malgorzata , Kollamkulam Mathew , Sonar Harshal , Paik Jamie , Clode Danielle , Hoffmann Matej , Cowie Dorothy , Makin Tamar
Published: February 2025

Some of the most dramatic examples of neuroplasticity in the human brain follow congenital sensory deprivation, though we have limited understanding of the plasticity mechanisms driving such large-scale remapping. Hand loss due to congenital limb differences (CLD) offers a unique temporal dissociation of developmental neuroplasticity mechanisms: While sensory deprivation is congenital, compensatory motor behaviours develop progressively across childhood. Using paediatric neuroimaging and semi-ecological behavioural analysis in children (5-7 years old) and adults (>25 years old) with unilateral upper-limb CLD, we studied deprivation- and use-dependent plasticity in the deprived primary somatosensory cortex and beyond. We reveal that global remapping, encompassing the entire sensory homunculus, is established early and maintained in adulthood. We demonstrate that deprivation-driven homeostatic plasticity can drive this global remapping, with Hebbian-based compensatory learning further contributing to inter-individual differences both in childhood and adulthood. Our findings emphasise the early establishment and stability of cortical maps, despite extensive daily-life behavioural adaptation.
PRMT1-Catalyzed NUSAP1 Methylation Enhances Notch2 Signaling and 5-FU Resistance in Gastric Cancer
Authors: wang feng , Jiang Suting , Li Guoli , Peng Shihan , Chen Shitong , Pang Yi , Cui Hongjuan
Published: February 2025

5-Fluorouracil (5-FU) resistance remains a significant challenge in the treatment of gastric cancer, limiting its clinical efficacy. Our study identifies NUSAP1, a nucleolar and spindle-associated protein, as a key driver of 5-FU resistance in gastric cancer. Proteomic analyses of 5-FU-resistant gastric cancer cell lines revealed that NUSAP1 is significantly upregulated, and functional studies demonstrated its essential role in promoting resistance, proliferation, migration, invasion, and tumor growth. Mechanistic investigations revealed that NUSAP1 undergoes asymmetric dimethylation (ADMA) at R418 and R422, mediated by PRMT1, with the R422 site being critical for its function. NUSAP1 interacts with the PEST domain of Notch2 through its R422 site, inhibiting Notch2 ubiquitination and stabilizing its expression, thereby activating the Notch2 signaling pathway. This pathway is closely linked to gastric cancer progression and chemoresistance. Inhibition of PRMT1 or mutation of the R422 site abrogated NUSAP1’s ability to stabilize Notch2 and regulate downstream signaling. These findings unveil a novel mechanism by which NUSAP1 promotes 5-FU resistance in gastric cancer and highlight the therapeutic potential of targeting the NUSAP1-Notch2 axis or PRMT1 in overcoming chemoresistance.
Why Do We Treat Hopeless Diseases? --A Philosophical and Ethical Inquiry into Patient and Physician Perspectives
Authors: Huang Ling-Lang
Published: February 2025

Background: Decision-making for futile medical care is a significant challenge in contemporary bioethics, requiring a balance between life extension, quality of life, and the value of life. This study explores the effectiveness of Shared Decision-Making (SDM) in the context of futile medical care.
Methods: This study adopts Heidegger's concept of "being-in-the-world" and Gadamer's "fusion of horizons" as its philosophical foundation. Semi-structured interviews were conducted with one patient and three treating physicians (a cardiologist, a cardiac surgeon, and a gynecologic oncologist). The Interpretative Phenomenological Analysis (IPA) method was used to analyze the reasons behind their willingness to pursue aggressive treatment despite evidence-based medicine (EBM) indicating futile care.
Results: The findings reveal that significant differences in values between physicians and patients profoundly influence decision-making for futile medical care. A "good decision" does not always equate to a "right decision." Furthermore, patients need to be "included in the horizon" of physicians, meaning they must be fully seen and understood as whole and independent individuals. This inclusion is a crucial prerequisite for achieving the "fusion of horizons," fostering deeper interaction and mutual understanding between physicians and patients.
Conclusions: Comprehensive SDM should be grounded in the "fusion of horizons" to promote meaningful understanding between physicians and patients. This study underscores the importance of integrating philosophical perspectives into clinical interactions to address the complexities of futile medical care. Three practical steps are proposed to enhance the implementation of SDM, offering guidance for clinical decision-making.
Prediction of major adverse cardiovascular events after immune checkpoint inhibitor related myocarditis with machine learning
Authors: Lu Jing , Lu Rui , Lu Mingjun
Published: February 2025

Objective
Immune checkpoint inhibitors (ICIs) have come into widespread use in oncology in recent years and are associated with rare cardiotoxicity, including potentially fatal myocarditis. To date, no model of the occurrence of major adverse cardiovascular events (MACE) in ICI‐related myocarditis has been constructed. In this paper, To construet a machine-learning-based model through diagnosis and treatment data of patients with ICI-related myocarditis to predict MACE in ICI-related myocarditis patients.
Methods
35 patients with ICI-related myocarditis from May 2019 to August 2023 at the First Affiliated Hospital of Guangzhou Medical University were selected as study subjects. The variables used for analvsis included basic information, immunotherapy-related indicators, laboratory indicators, cardiac examination-related indexes, and therapeutic regimen. Prediction model of the occurrence of MACE in ICI-related myocarditis patients was constructed with logistic regression, random forest (RF), extremegradient boosting, and light gradient boosting machine. Area under the curve (AUC) was adopted to evaluate the prediction efficacy of four prediction models. We also utilized SHapley Additive exPlanation (SHAP) values to explain the prediction model.
Results
MACE occurred in 17 patients, incidence of MACE was 48.6%. Comparatively, the RF model had the highest predictive performance among four models with an AUC of 0.892. The SHAP method reveals the top 6 predictors of MACE according to the importance ranking, and neutrophil to lymphocyte ratio was recognized as the most important predictor variable.
Conclusions
The machine learning methods were successfully established to predict MACE, and therefore, provides better treatment plans and optimal resource allocation for patients.
A three-dimensional high throughput assay identifies novel antibacterial molecules with activity against intracellular Shigella
Authors: Phat Voong Vinh , Lim Andrew , Cozar-Gallardo Cristina , Alvaro Maria Isabel Castellote , Alvarez Demetrio Muñoz , Alvaro Elena Fernandez , Ballell-Pages Lluis , Lozano-Arias Sonia , Baker Stephen
Published: February 2025

The Gram-negative bacterial species Shigella is the second leading cause of diarrhea among children in low and middle-income countries (LMICs) and is a World Health Organization (WHO) priority pathogen. Shigella infections are becoming increasing difficult to treat due to antimicrobial resistance (AMR), leading to an urgent for new antimicrobial agents with novel modes of action. Shigella pathogenesis is largely intracellular and antibacterial chemicals that preferentially work inside cells may be desirable to limit collateral AMR and block key components of the Shigella infection cycle. Aiming to facilitate the process of identifying antibacterial chemicals that kill intracellular Shigella, we developed a high-throughput screening (HTS) cell-based chemical screening assay. The three-dimensional (3-D) assay, incorporating Shigella invasion into Caco-2 cells on Cytodex3 beads, was scaled into a 384 well platform for screening chemical compound libraries. Using this assay, we evaluated > 500,000 compounds, identifying 12 chemical hits that inhibit Shigella replication inside cells. This simple, efficient and HTS-compatible assays circumvents many of the limitations of traditional screening methods with cell monolayers and may be deployed for antibacterial compound screening for other intracellular pathogens.
To be, or not to be an intron evidence from entropy-based machine learning
Authors: Mancini Alessio , Merelli Emanuela , Piangerelli Marco , Pucciarelli Sandra , Vito Leonardo
Published: February 2025

Alternative splicing (AS) of introns is a key mechanism contributing to proteomic diversity. It enables the generation of multiple mRNAs variants from a single gene sequence, which are subsequently translated into the distinct protein isoforms. Intron retention (IR) is a specific type of AS in which introns remain unspliced in the mature mRNA. The process of intron splicing is regulated by cis-regulatory elements that recruit small non-coding RNAs and heterogeneous nuclear ribonucleoproteins (hnRNP), collectively forming the spliceosome. However, the precise mechanism or “code” governing the splicing pattern of any primary transcript remains not completely understood. In this study, we present the use of explainable Machine Learning (xML) models to investigate the mecahnism underlying intron retention in mature mRNA. Intronic sequences obtained were analyzed from species within the ciliate genus Tetrahymena, providing unique insights into the IR process that are biased by tissue-specific factors. Various features of the intronic sequences were examined, including the absence of repetitive nucleotide motifs-quantified as “entropy”-the GC content, and the complexity of the secondary structures as estimated by the Lempel-Ziv (LZ) measure. Our findings indicate that the key distinguishing features of retained introns (RIs) compared to constitutively spliced introns include the reduced presence of repetitive nucleotide motifs within the intronic sequences and the compactness of secondary structures near the 3’ splice sites. These features appear to weaken splicing signals, impairing the recognition of intronic sequences and resulting in IR. In conclusion, our work offers insights into the regulatory code underlying intron retention in other organisms and highlights its potential role in modulating phenotypic plasticity. This supports a framework for understanding the epigenetic mechanisms of stress response and environmental adaptation, aligning with the “Lamarckian” perspective of evolutionary biology.
Synergistic effect of ammonium polyphosphate and silicone macromolecular charring agent on improving flame retardancy and mechanical properties of ethylene-butyl acrylate copolymer composites
Authors: Huo Xuan , Wu Bingcheng , Lou Yuanmeng , Zhu Junlin , Li Cui , Ma Lili , Hao Chuncheng , Wen Xin
Published: February 2025

It is still a challenge to achieve a good balance on flame retardancy and mechanical properties of polymer/intumescent flame retardants (polymer/IFRs) composites. In this work, a novel IFR system containing ammonium polyphosphate (APP) and silicone-containing macromolecular charring agent (Si-MCA) was constructed to synergistically improve the flame retardancy and mechanical properties of ethylene-butyl acrylate copolymer (EBA) composites. The optimal mass ratio of APP/Si-MCA was 3/1 in EBA composites (EBA/APP-Si-31), corresponding to the best flame retardancy with 31.2% of limited oxygen index (LOI), V0 rating in UL-94 test and 76.4% reduction on the peak of heat release rate (PHRR) in cone calorimeter test. The enhancement mechanism was ascribed to the synergistic effect of APP/Si-MCA during combustion, including the trapping radical effect, diluting effect of non-flammable gases, and the barrier effect of intumescent char layer. Meanwhile, tensile test indicated that EBA/APP-Si-31 also exhibited good mechanical properties with the addition of maleic anhydride-grafted polyethylene as compatibilizer. Thus, the APP/Si-MCA combination is an effective IFRs to prepare high-performance EBA composites, and will promote their applications as cable sheath materials.
An L1 norm regularization model for signal extraction from GNSS coordinate time series
Authors: Wang Zhuofan , Chen Gang , Li Hongwei , Bian Jiawen
Published: February 2025

Accurate signal extraction from Global Navigation Satellite System (GNSS) coordinate time series is crucial for geophysical studies. Primary focus of this paper lies in the recovery of trend and seasonal signals from observed GNSS coordinate time series. To achieve this, this paper presents a novel Modified L1-norm Regularization Rank-1 Matrix Completion (ML1MC) method, ML1MC leverages the low-rank property of Hankel matrices and incorporates automatic rank estimation and Block Coordinate Descent (BCD) to effectively handle noise and avoid overfitting, which provides a more comprehensive rank-1 matrix representation than Singular Value Decomposition (SVD) based low-rank matrix recovery methods. Extensive experiments on simulated and real GNSS datasets demonstrate ML1MC's superior performance in comparison to several State-Of-The-Art (SOTA) methods. Specifically, compared to the SOTA methods, ML1MC achieves over 7.8\% misfit reduction and reduces trend uncertainty error by more than 45.9\% under normal noise conditions.
The Impact of Perforation Presence, Preparation Design, and Prosthetic Treatment Options on Crack Propagation: A Finite Element Analysis Study
Authors: Güntekin Neslihan , Mutlu Şerefnur , Mohammadi Reza , Demirel Mehmet Gökberkkaan , Erdoğdu Meryem
Published: February 2025

Background: The aim of this study is to investigate the impact of restoration type and material on stress distribution in molar teeth with furcal perforations, as well as to evaluate the prognosis of cracks originating from the perforation site.
Methods: The molar tooth with a furcal perforation was restored using post-core restorations containing 1, 2, and 3 posts, as well as two different endocrown designs with and without a ferrule. Lithium disilicate (LDS) and polymer-infiltrated ceramic network (PICN) materials were used as the restoration materials. After modeling, von Mises values generated in the components were recorded using XFEM, and the progression of cracks originating from the perforation site was also examined. Fatigue values for dentin and crown were predicted.
Results: The investigations revealed that the LDS material exhibited better fatigue performance in all groups. Increasing the number of posts showed positive results for the perforation prognosis. Additionally, the presence of a ferrule in endocrown restorations improved the restoration's success.
Conclusion: In the presence of perforation, increasing the number of posts in post-core applications, when combined with ceramic restorations, is likely to result in a more successful prognosis in terms of survival. If endocrown restorations are to be chosen, the presence of a ferrule positively influences the success.
Data-driven multi-criteria decision making for cell performance detection in 5G and B5G networks
Authors: Yami Reza Moammer , Khazaei Ali Akbar , Quchani Saeed Rahati
Published: February 2025

Self-organizing communication networks in 5G and B5G automatically optimize and improve without human intervention, reducing OPEX and CAPEX. One of the critical features is self-healing, which predicts and resolves anomalies, optimizes performance, and adapts to changing cell density. This is managed through cell outage management (COM), which includes cell outage detection (COD) and cell outage compensation (COC). Timely prediction of cell state enhances network performance. This research uses machine learning techniques combined with multi-criteria decision making (MCDM) methods to rank and estimate defective cells. Using the TOPSIS method, an unsupervised dataset was transformed into a two-class supervised dataset. The results show that the TOPSIS-Adaboost combination outperforms other methods and improves the capabilities of cell outage detection in 5G and B5G networks.
Induction of Lewy-like aggregates perturbs the firing dynamics of midbrain dopaminergic neurons in vivo
Authors: Magill Peter J , Schaffran Barbara T , Wolff Amy R , Threlfell Sarah , Doig Natalie M , Dinneen David , Yona Guy , Sharott Andrew , Luc Kelvin C , Cragg Stephanie J , Dodson Paul D
Published: February 2025

Lewy-bodies are protein aggregates that are thought to lead to neurodegeneration in Parkinson’s disease. However, little is known about the contributions of these aggregates to the symptomatology of the disease. We injected alpha-synuclein pre-formed fibrils (PFFs) into dorsolateral striatum to induce Lewy-like aggregates in substantia nigra dopamine neurons and examined the effects 1- and 3-months post-injection, stages that are prior to overt cell loss. Aggregate-bearing dopamine neurons exhibited an increase in burst-firing in vivo and their firing became synchronized with cortical activity. Aggregates had a progressive effect on dopamine neuron activity, with a decrease in firing rate observed 3-months after PFF injection. In addition to altered neuronal firing, PFFs caused a reduction in evoked dopamine release and in the rate of dopamine uptake measured in striatal slices. Furthermore, alpha-synuclein aggregates were detected in dopaminergic axons in striatum and a loss of these axons was observed prior to cell body degeneration. These findings suggest that at early stages of disease, Lewy-like aggregates cause loss of dopaminergic axons and alter both the rate and pattern of dopamine neuron firing. Thus, aggregates may not only be instrumental in neurodegeneration, but may also play a role in the symptoms of Parkinson’s disease.