bluuebunny/crossref_metadata_2025 huggingface dataset:
Paternal psychopathology among children with generalised anxiety disorder (GAD)
Authors: Alyasin Seyed Ali
Published: January 2019

The aim of the current study was to identify the role of psychopathology and family functioning among fathers of children with generalised anxiety disorder (GAD). A total of 198 fathers (including 95 fathers of children with GAD and 103 fathers of normal children) completed two questionnaires: i) Socio-demographic Questionnaire; ii) Family assessment device. Results show that there are significant differences between the fathers of both groups on the subscales of affective responsiveness, behaviour control and general function (P < 0.05). There were no significant differences between two groups on dimensions of problem-solving, communication, roles and affective involvement (P > 0.05). On the whole, the study showed that GAD is associated with some degrees of paternal psychopathology and family dysfunction. These results support findings of other psychopathological research studies that revealed GAD is a moderately familial disorder.

 

Keywords: Psychopathology, children, generalised anxiety disorder.
Ecos hesiódicos en Eurípides, Hipólito, 616-668
Authors: García Pérez David
Published: January 2019

Los versos 616-668 del Hipólito de Eurípides presentan una diatriba de este personaje contra la mujer en general, a propósito de la pasión que Fedra, su madrastra, siente por él. Los argumentos de este breve discurso abonan la idea de la maldad femenina, al punto de plantear que ésta no debería de existir. Con la finalidad de explorar el imaginario masculino sobre el tópico de la mujer, nuestro análisis radica en la exposición de los ecos de Hesíodo en esta tragedia de Eurípides, pues es relevante hallar que el modo de pensar a la mujer guarda en dos momentos históricos bien diferenciados (el período arcaico y el período clásico) similitudes que hacen pensar en un estancamiento social. Este trabajo es una aportación a los estudios sobre poesía griega antigua desde el punto de vista de la tradición literaria en torno a la figura de la mujer.
Los límites del odio: la compasión de Odiseo en Áyax de Sófocles
Authors: Eslava-Bejarano Santiago
Published: January 2019

En el prólogo de Áyax, Odiseo se compadece de su enemigo en desgracia. Este artículo se ocupa de la dimensión ética de esta emoción y del lugar que juega en la obra. Un estudio de las condiciones cognitivas que la soportan permite comprender la relación que tiene con una determinada noción de justicia y, además, muestra la unidad misma de esta tragedia, comúnmente puesta en duda. Finalmente, a partir de esta investigación es posible reconocer que Sófocles presenta una visión de mundo de acuerdo con la cual el odio y el sufrimiento que es justo infligir a un enemigo tienen límites.
Cuestiones acerca de la teúrgia en Proclo: metafísica, eros y ritual en el platonismo de la antigüedad tardía
Authors: Redondo José Manuel
Published: January 2019

Este artículo se propone retratar los complejos modos en que se relacionan la teúrgia o práctica ritual y la filosofía en el platonismo posplotiniano tardo-antiguo, particularmente en Proclo (s. V), uno de los más sobresalientes filósofos helenos. Actividad de un eros divino, la teúrgia opera de acuerdo con principios filosóficos, es vista como una herramienta ética. También es vinculada con lo que Platón llama la manía o locura sagrada. Asimismo, se relaciona con la mántica, el arte hierática y la teléstica. El principal objetivo de este artículo es apuntar hacia una necesaria modificación de la comprensión aún predominante acerca de la filosofía platónica de este período, así como resaltar la vinculación de la teúrgia con campos del saber que suelen ser vistos como independientes dentro de la misma filosofía, arrojandocon ello una interpretación más completa acerca de la compleja práctica filosóficaque desarrollaron los platónicos tardíos.
RUSSIAN LANGUAGE TEACHING AS A FOREIGN LANGUAGE
Authors: Tsurtsilina Natalya Nikolayevna
Published: January 2019

We advise to use authentic materials in Russian language teaching as a foreign language. We focus on the textual approach. We give recommendations for methodical selection and literary and poetic text organization to form a foreign language communicative competence. We consider the specificity of communication in a foreign language teaching. The understanding and producing speech in a foreign language is also important. The teacher should have the means to analyze not only the authentic artistic/poetic texts he/she introduces into the teaching but also the texts produced by the students themselves in order to advise, support, assist and consult. The teacher’s aim is firstly to ensure that students are familiar with the maximum number of different texts samples in a foreign language, and then to help them to structure these data, to organize their presentation, and learn the data, to offer different activities using various linguistic and cognitive operations, finally to evaluate and to create conditions for self-assessment of their own communicative competence.
JESUS CHRIST’S IMAGE TRANSFORMATION IN THE WORKS BY A. BLOK: FROM EARLY WORKS TO THE POEM “THE TWELVE”
Authors: Grudinina Elena Valeryevna
Published: January 2019

We present the analysis the image of Jesus Christ in the early lyric poetry and the final chapters of the poem “The Twelve” by A. Blok from the point of view of Orthodox spiritual thought. The study allows us to conclude that the poet, despite the specific creative manner of symbolism, very accurately conveys in his early works not only the crisis perception of the world, typical of society at the turn of the 19th and 20th centuries, but also a deep personal insight into the essence of Orthodox faith. As a result of comparing the image of Christ in the analyzed lyric works with the final image in the poem “The Twelve”, which received many different interpretations in critical literary practice, as well as the writings of philosophers and theologians, we conclude that Alexander Blok with his fine poetic ear and spiritual vision, astonishing accuracy portrayed the moral emptiness of people who had created an idol for themselves from a false idea. The element of destruction, the whirlwind of snow, which gave rise to the “tender” image of the false Christ, in fact poses a mortal danger to the human soul.
System-level Insights into the Adaptation of Domestic Dairy Buffalo to Chronic Heat Stress
Authors: Gu Zhaobing , Tang Shoukun , Fu Xianhai , Liu Chuanbin , Mao Huaming
Published: January 2019

Chronic heat stress (HS), aggravated by global warming, reduces the production efficiency of the buffalo dairy industry. Here, we conducted a proteomic analysis to investigate the adaptation strategies used by buffalo in response to heat stress. Seventeen differentially abundant proteins with known functions were detected using label-free quantification (LFQ), and five of these differentially expressed proteins were validated with parallel reaction monitoring (PRM). These five proteins were associated with various aspects of heat stress, including decreased heat production, increased blood oxygen delivery, and enhanced natural disease resistance. Lipase (LPL), glutathione peroxidase 3 (GPX3), cathelicidin-2 (CATHL2, LL-37), ceruloplasmin (CP), and hemoglobin subunit alpha 1 (HBA1) were shown to play cooperative roles in the tolerance of chronic HS in dairy buffalo. We found that high levels of HBA1 increased blood oxygen transport capacity. Our results increase our understanding of the adaptation of dairy buffalo to chronic heat stress.
Optical Biosensors Based on Silicon-On-Insulator Ring Resonator: A Review
Authors: Steglich Patrick , Hülsemann Marcel , Dietzel Birgit , Mai Andreas
Published: January 2019

Recent developments in optical biosensors based on integrated photonic devices are reviewed with a special emphasis on silicon-on-insulator ring resonator. The review is mainly devoted to the following aspects: (1) Principles of sensing mechanism, (2) sensor design, (3) biofunctionalization procedures for specific molecule detection and (4) measurement set-ups and advances in chip-integration. The inherent challenges of implementing photonics-based biosensors to meet specific requirements of applications in medicine, food analysis, and environmental monitoring are discussed.
Accuracy of Eddy-Current and Radar Methods Used to Reinforcement Detection
Authors: Drobiec Łukasz , Jasiński Radosław , Mazur Wojciech
Published: January 2019

Currently, the most often NDT methods used in practice to non-destructive rebar location in structures are: electromagnetic and radar methods. Both methods have some advantages, disadvantages and limitations. In work, an attempt to describe the possibilities of the particular methods with emphasizing their advantages and limitations has been made. The results of the tests conducted on a lintel beam made of AAC reinforced with small diameter rebars and with rebars placed close together have been presented. The reinforcement has been tested with two different electromagnetic scanner and a GPR device. The received results of eddy-current tests have been compared with the results of NDT tests. It has revealed that NDT tests done in this kind of element allow the correct assessment of the concrete cover but can give different results in case of shape and number of rebars.
Генотоксичное воздействие наночастиц диоксида титана на двустворчатого моллюска Mytilus trossulus (Gould, 1850) в морской среде
Authors: Кукла С. П. , Слободскова В. В. , Челомин В. П.
Published: January 2019

Увеличение поступления наночастиц диоксида титана (TiO2) в морскую среду способно вызвать непрогнозируемые последствия и создать потенциальную опасность для организмов различных трофических уровней. С помощью метода ДНК-комет изучено воздействие наночастиц диоксида титана на двустворчатого моллюска Mytilus trossulus (Gould, 1850), оценены уровни повреждения ДНК. Показано, что 10-дневное воздействие TiO2 в концентрациях 200 и 1000 мкг·л-1 приводит к деструктивным изменениям ДНК жабр и пищеварительной железы моллюска. Отмечены различия степени повреждения ДНК у двух исследуемых тканей. В пищеварительной железе моллюска зафиксировано увеличение концентрации титана и малонового диальдегида.
Improvisation as Contingent Encounter, Or: The Song of My Toothbrush
Authors: DiPiero Dan
Published: January 2019

This article hazards a definition of improvisation as a "contingent encounter," not in order to settle definitional debates, but in order to productively re-evaluate questions around improvisation as an aesthetic and socio-political force. Here, I argue that thinking improvisation through contingency highlights several key characteristics while leaving behind a set of problematic assumptions that often accompanies thinking improvisation in social spaces. First, I outline these characteristics, establishing what it might mean to bring contingency to bear on a musical performance. Subsequently, I compare two instances of "transatlantic improvised music": Eric Dolphy's "Out to Lunch," and "Waves, Linens, and White Light" by contemporary free improvisers, Mr. K. I conclude by sketching some of the implications of taking this experimental definition seriously, arguing that it re-orients improvisation away from a rarefied behavior and more towards a potentiality hidden inside each moment.
MYSTICO-PHILOSOPHY
Authors: Naim Ngainun
Published: January 2019

This article aims to offer an epistemological concept on scientific integration between religious and secular sciences proposed by a prominent Indonesian thinker Mulyadhi Kertanegara. The scientific integration (integrasi keilmuan) is essential concept explaining a contemporary development of Indonesian-state Islamic universities as exemplified by institutional transformation from exclusively Islamic studies learning institution of State Islamic Institute for Islamic Studies/IAIN to scientific integration of State Islamic University/UIN. As this article argues, let alone the institutional transformation, philosophical transformation of Islamic higher educational learning is a crucial element. It is the foundation of the institutional transformation and is still a major problem for contemporary Indonesian Islamic higher education. This article further argues that the philosophical transformation includes the construction of scientific and academic cultures and tradition which are applicable to contemporary Indonesian Islam higher educational system. Taking a root to the concepts of Islamic philosophy, Mulyadhi Kartanegara’s mystical-philosophical concept is indeed an innovative offer which is crucial as an alternative foundation of contemporary transformation of Islamic higher education in Indonesia and an answer to scientific debates on the relationship between religion and secular science.
HELLENISM IN ISLAM
Authors: Fauzan Pepen Irpan , Fata A Khoirul
Published: January 2019

The early Muslim society took much of the scientific treasures from other civilizations, especially from ancient Greek. One of the scientific traditions taken from Greek is Hellenism. Using a historical approach, this article tries to assess the contiguity of Islam with the Hellenism. There are three points will be discussed: When has Islam met to the Hellenism in first time? What are the factors that support the scientific contact between both of the civilizations? To what extent Hellenism influenced the development of scientific tradition in early Muslim community? Our study shows that the Muslims have known the Hellenistic tradition since the 7th century in Ummayyad era, not the 8th century as some scholars claim. Second, there are three factors underlying early Muslim studied Hellenism (1) Support from Qur’anic teachings, (2) The need to argue with both of other Muslim groups and Non-Muslims community, (3) The need of the Caliphs to legitimize their power. Third, when Muslims have known the Hellenism, they did not only adopt the Hellenism ideas, but also provide reviews, critical notes, and further more developed its own scientific tradition combined with the qur’anic teachings.
POLITICAL ISLAM AND THE GLOBAL ECONOMY
Authors: Irkhami Nafis
Published: January 2019

This article discusses the entanglement of political Islam and the new global economy. It specifically addresses the epistemic fields of political economic concepts of the Islamist organisation of Hizbut Tahrir Indonesia/HTI. This article argues that the organisation offers an entangled epistemic field of religion, politics, and economy. The Islamic concept of khilafah is particularly defined as a new global political and economic systems that challenge the currently dominant capitalist-state of western civilisation. The crucial elements of political economy of the khilafah is the aspect of distribution rather than production, thus the HTI’s criticism lies at the notion of justice and equal access to economic resources and effects. With this framework, the HTI offers a new global political system -based on khilafah- and promises justice in economic distribution.
NON-MUSLIM LEADERSHIP POLEMIC IN INDONESIA
Authors: Bahri Syaiful
Published: January 2019

This article tries to contextualise the formulation of Islamic laws with regards to contemporary dynamics of non-Muslim leadership in the government. It particularly addresses the religious deliberation (ijtihad) of the traditionalist Muslim organisation, the Nadhlatul Ulama/NU, and its youth organisation, the Gerakan Pemuda Ansor. The construction of Islamic laws in contemporary Indonesia tells an insightful viewpoint in Islamic-laws making and delivers multiplicity in Islamic interpretation. Despite the fact that these two organisations are of the same organisation, the NU, their formulation of Islamic laws with regards to non-Muslim leadership demonstrates a different and contrasting opinion. While the national board of the NU through its national congress in 1999 argues against non-Muslim leadership, the national religious deliberation board (bahtsul masail) of the Ansor in 2017 issues a legal opinion that approves non-Muslim leadership. As this article argues, the different opinions between these two institutions develops particularly because of different construct in defining Islam and democracy in the largest Muslim country Indonesia. They differ in reconciling istinbat (methods for formulating the laws) of two principles of Islamic laws (ushul al-fiqh); al-sabit (permanent) and al-mutahawwil (change). It further argues that the national board of the NU particularly sees the prohibition of non-Muslim leadership as al-sabit, an unchanged dictum, whereas the Ansor considers it al-mutahawwil as looking at the Indonesian state constitution that does not discriminate its citizens based on religion. Thus, making Islamic laws accords to the state constitution.
1834 VE 1840/41 TARİHLİ NÜFUS DEFTERLERİNE GÖRE KARASINIR VE ELMASUN (GÜNEYSINIR)
Authors: MUŞMAL Hüseyin , ÖZÇELİK Mehmet
Published: January 2019

Günümüzde Konya ilinin Güneysınır ilçesinin merkez mahallelerini oluşturan Karasınır ve Elmasun, Osmanlı Devleti döneminde Konya Vilayeti’nin Belviran Kazası’na bağlı köyler idi. Bu iki yerleşim yerinin bağlı bulunduğu idarî birim olan Belviran Kazası’na ait 1834 ve 1840/41 tarihli nüfus defterleri, Türkiye Cumhuriyeti Başbakanlık Devlet Arşivleri Genel Müdürlüğü Osmanlı Arşivleri Daire Başkanlığında BOA, NFS.d katalogunda sırasıyla 3373 ve 3374 numarada kayıtlıdır. 1834 yılına ait 3373 numaralı defter, sayfa usûlü numaralandırılmış olup toplam 67 sayfadan oluşmaktadır. Defterle ilgili bilgi formunda verilen bilgilere göre, defterin başlangıç tarihi 27 Şubat 1834’tür. 1840/41 yıllarına ait 3374 numaralı Belviran Kazası Nüfus Defteri ise varak usûlü numaralandırılmış olup 224 sayfadan oluşmaktadır. Her iki defterde de nüfus kayıtları hane esasına göre tutulmuştur. Nüfus verilerinin kaydedilmesinde hane reisi esas alınmış, ilk olarak hane reisi yazıldıktan sonra sırayla o hanede yaşayan erkek nüfus kaydedilmiştir. Defterlerde kadın nüfusa dair herhangi bir kayıt bulunmamaktadır. Çalışmamıza konu olan nüfus defterleri, Karasınır ve Elmasun’da yaşayan erkek nüfusun, isim, baba ismi, lakap, yaş ve eşkal bilgilerini ihtiva etmektedir. Dolayısıyla çalışmamızda, 1834 ve 1840/41 yıllarına ait nüfus defterlerindeki verilerin değerlendirilmesi suretiyle XIX. yüzyılın ikinci çeyreğinde Karasınır ve Elmasun köylerinin demografik yapısı, sosyal ve kültürel özellikleri ele alınacaktır.
MERKEZİ OTORİTE KARŞISINDA BİR DAĞLI EŞKIYASI: DELİ KADRİ
Authors: ŞİMŞEK Eyyub
Published: January 2019

Dağlı eşkıyalarının Rumeli’yi kasıp kavurduğu dönemde Bergos civarında pek de meşhur olmayan Deli Kadri adlı bir eşkıya faaliyette bulunmaktaydı. Deli Kadri’nin politik arzulardan uzak, yağmacılığa dayalı faaliyetleri onu sıradan bir eşkıya yapmaktaydı. Belki de bu yüzden tarihçilerin dikkatini çekememişti. Hâlbuki Osmanlı imparatorluğunun onun gibi sıradan bir eşkıya ile mücadelesi devletin eşkıyaya yönelik siyasetinin belirlenmesinde önemli ipuçları verebilmektedir. Bu çalışma, onun devlet ile olan ilişkileri aracılığıyla dönemin portresine bir katkı sağlamayı amaçlamaktadır. Başbakanlık Osmanlı Arşivi’ne dayanılarak yapılan bu çalışmada bir eşkıyanın merkezi otoriteyi nasıl uğraştırdığı ortaya konulmaya çalışılırken, diğer taraftan devletin eşkıyalara yönelik izlediği politikalar ele alınarak değerlendirilmeye çalışılacaktır.
YABANCI RESSAMLARIN (15. YÜZYIL) TABLOLARINDA GÖRÜLEN TÜRK HALILARINDA RENKLER
Authors: AYTAÇ Ahmet
Published: January 2019

Yabancıların Türk halılarına olan ilgisi yüzyıllardır bilinmektedir. Özellikle XV. yüzyıldan sonra Avrupalı ressamlar tablolarında Türk halısı tasvirlemişlerdir.Tablolardaki renkler ile tasvirlenen halının renkleri arasında bir bağ olduğu düşünülmektedir. XV. ve XVI. yüzyılın başlarında resim yapmış Rönesans ressamlarının bir kısmının bazı tablolarında Türk halıları vardır. Bu halıların desen analizi ve halıdaki renklerle tablodaki diğer renkler arasındaki bağlantı bu araştırma ile tespit edilmeye çalışılmıştır.
XIX. YÜZYILDA TIRHALA SANCAĞI’NIN İDARİ TAKSİMATI VE YÖNETİMİ
Authors: Çiftçioğlu Ferdi
Published: January 2019

Tırhala sancağı, XIV. yüzyılın sonlarında Osmanlı hâkimiyetine girmiştir. Devletin Balkanlarda ilk fethettiği yerler arasında yer alan sancak, 1881 yılına kadar Osmanlı idari taksimatındaki yerini korumuştur. Kuruluşundan XIX. yüzyılın ortalarına kadar Rumeli Eyaletine bağlı statüsünü koruyan sancak, Tanzimat’ın ilanıyla birlikte Osmanlı taşrasında uygulanan idari değişikliklerin görüldüğü idari birimler arasında yer almıştır. Rumeli Eyaleti’nin küçültülüp küçük eyaletler teşkil edilmesi kararının ardından 1847 yılında Üsküp, Bosna, Yanya ve Selanik eyaletleri kurulmuştur. Sancak, bu eyaletlerden önce Selanik’e sonra Yanya’ya bağlı şekilde varlığını sürdürmüştür. Sancağın kendisi de kısa bir süre eyalet konumuna yükseltilmiş fakat 1871 Vilayet Nizamnamesiyle kesin olarak Yanya Vilayeti’ne bağlanmıştır. Ayrıca sancağın alt birimlerinde sürekli idari değişikliklerin yaşanması, Tanzimat’ın taşra yönetim uygulamalarının oturmadığını göstermiştir. IV. asırda durumunu muhafaza edebilen sancak, Tanzimat’ın ilanından sonra 1881 yılında Yunanistan’a terkine kadarki yaklaşık kırk senede birçok idari değişikliğin uygulandığı Osmanlı idari birimi olmuştur.Bu çalışma, Tanzimat’ın Osmanlı taşra yönetimine getirmiş olduğu yenilikleri ve değişiklikleri, Tırhala Sancağı üzerinden ortaya koymayı amaçlamıştır. Bu bağlamda sancağın geçirmiş olduğu idari değişiklikler ile yönetime yardımcı sancak meclislerinin görevleri üzerinde durulmuştur. Ayrıca sancağın tüm idari şemasının verilmesiyle araştırmacıların sancağı dönemin diğer sancakları ile karşılaştırabilmeleri amaçlanmıştır. Bütün bunların ötesinde, devletin Balkanlar üzerindeki taşra yönetim anlayışının diğer sancaklarından farklı olmadığını ortaya koymak çalışmanın temel amacını oluşturmuştur
Nurse plants and the regeneration niche of tree seedlings in wood-pastures from Western and North-Western Romania
Authors: Fodor Ecaterina , Haruta Ovidiu , Dorog Sorin
Published: January 2019

Facilitation is a positive interaction demonstrated to be one of the important factors shaping the regeneration niche of trees, mostly under stressful conditions which is currently studied in the frame of complex ecological networks. The protection provided by benefactor plants for tree seedlings playing the role of beneficiaries is documented mainly in arid and semi-arid habitats or in situations where herbivores’ pressure constitutes the main stressful factor for tree regeneration. One of the iconic Transylvanian landscapes is the wood-pasture, also one of the oldest agro-forestry systems to which recent forest expansion in abandoned agricultural fields or pastures is added. The proposed work represents a preliminary investigation on the association between benefactor plants, mostly spiny shrubs (Rosa canina, Crataegus monogyna, Prunus spinosa as the most frequently encountered benefactors) and tree seedlings (Quercus spp., Tilia spp., Carpinus betulus, Fraxinus angustifolia, Pyrus pyraster as most frequently encountered beneficiaries), in four different locations from North-Western and Western Romania, wood-pastures, abandoned pastures and abandoned agricultural fields under the consideration that the main stressful factor is represented by livestock grazing. Bipartite, qualitative merged network was generated depicting the interaction between beneficiaries and benefactors. Commonly used metrics were calculated: connectivity, nestedness, modularity, betweenness centrality and centralization compared to similar facilitation networks presented in the literature. Facilitation network is characterized by high nestedness (N=0.896), lack of modularity, relatively high connectance (C=0.233), features encountered in mutualistic networks also. Betweenness centrality scores highlighted the keystone benefactor and beneficiary species, while betweenness centralization score (0.192) indicates the fact that there are several species sharing the dominant position in terms of interactions. The analysis of measurement data (seedlings’ and benefactor plants’ heights, distance from focal seedlings to nearest benefactor species and orientation) showed that there is common pattern in orientation (most of the benefactor species oriented toward South or South West) also in dimensional variability (MANOVA results).
PROBLEM-BASED ENGLISH SPEAKING MATERIAL TO ENHANCE STUDENTS’ CRITICAL THINKING SKILLS
Authors: Rahmawati Nur , Ashadi Ashadi
Published: January 2019

This study was aimed at examining the development of problem-based English speaking materials and the elements in the problem-based English speaking materials which can enhance grade X students’ critical thinking skills. Employing a Research and Development design using Jolly and Bolitho’s model (1998), the study collected data through observations, tests, interviews, and questionnaires to reach a comprehensive needs analysis. A total of 90 grade X students participated in the study. The product of this study was a set of supplementary materials for teaching speaking. Six units were developed; each of which consisting of six parts reflecting the problem-based stages. Based on the expert judgment, the mean score for all chapters was 3.69, equivalent to the range score of 3.25 ≤ x ≤ 4 (very good). Chapter I and II were tried out to the students. The response showed that the mean score of each chapter was 3.2, equivalent to the range score of 2.5 ≤ x ≤ 3.24 (good). To conclude, the materials are appropriate to be used by 10th graders because it meets their needs and it is designed based on the current curriculum.MATERI BERBICARA BAHASA INGGRIS BERBASISKAN MASALAH UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITISAbstrakPenelitian ini bertujuan untuk mengetahui pengembangan materi berbicara bahasa Inggris berbasiskan masalah dan elemen-elemen dalam materi berbicara bahasa Inggris berbasiskan masalah yang dapat meningkatkan kemampuan berpikir kritis siswa kelas X. Dengan melakukan penelitian dan pengembangan dengan mengadaptasi model Jolly dan Bolitho (1998), data dalam penelitian ini dikumpulkan melalui observasi, tes, wawancara, dan angket untuk mendapatkan hasil analisis kebutuhan yang komprehensif. Siswa kelas X sejumlah 90 orangberpartisipasi dalam penelitian ini. Hasil dari penelitian ini adalah satu set materi pendukung untuk mengajar berbicara. Enam unit materi sudah dikembangkan. Setiap unit berisi beberapa bagian yang mencerminkan langkah dalam pembelajaran berbasis masalah. Berdasarkan penilaian ahli, nilai rata-rata dari semua unit adalah 3,69 yang ekuivalen dengan rentang 3.25 ≤ x ≤ 4 dengan kriteria “sangat baik”. Unit I dan II diujicobakan. Respons siswa menunjukkan nilai rata-rata masing-masing unit sebesar 3,2 yang ekuivalen dengan rentang 2.5 ≤ x ≤ 3.24 dengan kriteria “baik”. Kesimpulannya, materi yang sudah dikembangkan layak untuk digunakan karena sesuai dengan kebutuhan siswa dan kurikulum yang digunakan.
THE EFFECTIVENESS OF CHEMICAL MODULE WITH COMPENDIUM VERSES QURAN IN PESANTREN-BASED SCHOOL
Authors: Hidayati Nurul - , Saputro Sulistyo , Susilowati Endang
Published: January 2019

This study was aimed at determining the effectiveness of chemical modules with compendium verses Quran to improving student learning outcomes in Pesantren-based school. The study used the research and development method with five stages: analysis, design, development, implementation, and evaluation. The data show that 99% of students and teachers need comparative science course modules with compendium from the Quran. The modules that have been produced are validated by material experts, linguists, learning experts, media experts, and practitioners. The results show that the module has been feasible to be implemented in classroom learning. The validation results show that the product is valid and feasible to use. The trial is limited and the main test is performed after module revision. The average pretest and posttest results show that with the use of the development module the results increase, so the use of this module is more effective because it improves students’ achievement. The significance value of the t-test is 0.001 which means there is an influence on the use of chemical modules with compendium verses from the QuranKEEFEKTIFAN MODUL KIMIA DENGAN KOMPENDIUM AYAT-AYAT ALQURAN PADA SEKOLAH BERBASIS PESANTRENAbstrakPenelitian ini bertujuan untuk menguji efektivitas modul kimia dengan dilengkapi kompendium ayat-ayat Alquran dalam meningkatkan hasil belajar siswa pada sekolah berbasis pesantren. Penelitian ini merupakan penelitian pengembangan dengan lima tahapan yaitu: analysis, design, development, implementation, dan evaluation. Data menunjukkan bahwa 100% siswa dan guru membutuhkan modul mata pelajaran kimia berkompendium Alquran. Modul yang telah dihasilkan divalidasi oleh ahli materi, ahli bahasa, ahli pembelajaran, ahli media, dan praktisi. Hasil menunjukkan bahwa modul layak diimplementasikan dalam pembelajaran di kelas. Hasil validasi menunjukkan bahwa produk tersebut valid dan layak untuk digunakan. Uji coba terbatas dan uji coba utama dilakukan setelah dilakukan revisi modul. Hasil rata-rata pretest dan posttest menunjukkan terjadinya peningkatan hasil dengan penggunaan modul pengembangan. Penggunaan modul ini lebih efektif karena meningkatkan prestasi siswa. Nilai signifikansi dari uji-t adalah 0,001. Artinya, terdapat pengaruh pada penggunaan modul kimia dengan kompendium ayat-ayat Alquran.
BUILDING DEMOCRACY OF CULTURE IN SCHOOL THROUGH JURISPRUDENTIAL INQUIRY
Authors: Japar Muhammad , Fadhillah Dini Nur , Kardiman Yuyus , Yasnita Yasnita , Sarkadi Sarkadi
Published: January 2019

This study was aimed at developing democratic culture in high schools through Jurisprudential Inquiry. The study used a descriptive qualitative approach by observing the planting of democratic values applied in the subjects of Citizenship Education by applying the jurisprudential inquiry learning model. The jurisprudential inquiry learning model empirically had built a dynamic learning atmosphere. This model provided opportunities for students to disagree but based on the accurate data and no need to be ashamed or inferior to acknowledge that the opinions of other students were better and they were willing to support that opinion. Thus, this model allows constructive debate. This practice was able to build values of respect for differences of opinion in the learning process. The results show that the jurisprudential inquiry learning model can be an alternative model in developing a democratic culture. Democratic values applied were actively participating in school activities, respecting diversity, familiarizing deliberations and maintaining a balance between rights and obligations in school.MEMBANGUN BUDAYA DEMOKRASI DI SEKOLAH MELALUI JURISPRUDENTIAL INQUIRYAbstrakPenelitian ini bertujuan mengembangkan budaya demokrasi di Sekolah Menengah Atas melalui Jurisprudential Inquiry. Pendekatan penelitian yang digunakan adalah pendekatan kualitatif deskriptif dengan mengamati penanaman nilai-nilai demokrasi yang diterapkan dalam mata pelajaran Pendidikan Kewarganegaraan dengan menerapkan model pembelajaran jurisprudential inquiry. Model pembelajaran jurisprudential inquiry secara empirik telah membangun atmosfer pembelajaran yang dinamis. Model ini memberikan peluang bagi siswa untuk berbeda pendapat tetapi berdasarkan data yang akurat dan tidak perlu malu atau rendah diri untuk mengakui bahwa pendapat siswa yang lain itu lebih baik dan rela mendukung pendapat itu. Dengan demikian, model ini memungkinkan terjadinya perdebatan yang kontruktif. Praktik ini mampu membangun nilai menghargai perbedaan pendapat dalam proses pembelajaran. Hasil penelitian ini menunjukkan bahwa model pembelajaran jurisprudential inquiry dapat menjadi model alternatif dalam mengembangkan budaya demokrasi yaitu berpartisipasi aktif dalam kegiatan sekolah, menghargai keragaman, membiasakan musyawarah dan menjaga keseimbangan antara hak dan kewajiban di sekolah.
Evaluation of a Mobile Device Survey System for Behavioral Risk Factors (SHAPE): App Development and Usability Study
Authors: Oakley-Girvan Ingrid , Lavista Juan M , Miller Yasamin , Davis Sharon , Acle Carlos , Hancock Jeffrey , Nelson Lorene M
Published: January 2019

Background

Risk factors, including limited exercise, poor sleep, smoking, and alcohol and drug use, if mitigated early, can improve long-term health. Risk prevalence has traditionally been measured using methods that now have diminished participation rates. With >75% of American citizens owning smartphones, new data collection methods using mobile apps can be evaluated.

Objective

The objective of our study was to describe the development, implementation, and evaluation of a mobile device–based survey system for behavioral risk assessment. Specifically, we evaluated its feasibility, usability, acceptability, and validity.

Methods

We enrolled 536 students from 3 Vermont State Colleges. Iterative mobile app development incorporated focus groups, extensive testing, and the following 4 app versions: iOS standard, iOS gamified, Android standard, and Android gamified. We aimed to capture survey data, paradata, and ambient data such as geolocation. Using 3 separate surveys, we asked a total of 27 questions that included demographic characteristics, behavioral health, and questions regarding the app’s usability and survey process.

Results

Planned enrollment was exceeded in just a few days. There were 1392 “hits” to the landing page where the app could be downloaded. Excluding known project testers and others not part of the study population, 670 participants downloadeded the SHAPE app. Of those, 94.9% of participants (636/670) agreed to participate by providing in-app consent. Of the 636 who provided consent, 84.3% (536/636) were deemed eligible for the study. The majority of eligible respondents completed the initial survey (459/536, 85.6%), whereas 29.9% (160/536) completed the second survey and 28.5% (153/536) completed the third survey. The SHAPE survey obtained 414 participants on the behavioral risk items in survey 1, which is nearly double the 209 participants who completed the traditional Vermont College Health Survey in 2014. SHAPE survey responses were consistent with the traditionally collected Vermont College Health Survey data.

Conclusions

This study provides data highlighting the potential for mobile apps to improve population-based health, including an assessment of recruitment methods, burden and response rapidity, and future adaptations. Although gamification and monetary rewards were relatively unimportant to this study population, item response theory may be technologically feasible to reduce individual survey burden. Additional data collected by smartphones, such as geolocation, could be important in additional analysis, such as neighborhood characteristics and their impact on behavioral risk factors. Mobile tools that offer rapid adaptation for specific populations may improve research data collection for primary prevention and could be used to improve engagement and health outcomes.
SYNTHESIS OF SOME NOVEL PYRAZOLE DERIVATIVES AND EVALUATION OF THEIR PURIFICATION OF CHROMATOGRAPHY IN THIN-LAYER CHROMATOGRAPHY
Authors: B Swapna , M Vijey Aanandhi
Published: January 2019

Objective: The main objective of the study is to synthesis some novel pyrimidine scaffold which has wide range of properties of biological activities.Methods: Synthesis of different pyrazole derivatives compounds identification and characterization (M.P, solubility, Rf values, and spectral studies). The present work was characterized by infrared, nuclear magnetic resonance, and mass spectral analysis pharmacological evaluation.Results: Identification and characterization (M.P, solubility, Rf values and spectral studies) are carried out.
APPLICATION OF IN SILICO STUDIES TARGETING TELOMERIC G-QUADRUPLEX COMPLEX BY PERYLENE DIIMIDES FOR ANTICANCER THERAPY
Authors: Cn, Hemalatha , M Vijey Aanandhi
Published: January 2019

Objective: Telomerase enzyme which is expressed in detectable levels and its mechanism was that it increases the length when it binds to telomeres. This eventually leads to extension of lifespan of cells and also makes an attractive target for cancer therapy. Perylene diimides bind to telomerase with duplex genomic DNA, and these G-quadruplex ligands are of responsible for binding affinity with respective proteins. Based on the IC50 values of perylene diimides, QSAR has been studied out and the results are elaborated in preliminary research works. From the results of QSAR, the selected perylene ligands are selected for docking choosing telomerase as a target/protein. From the results of in silico studies, new compounds are designed and synthesized accordingly. Now, the objective of the study was to dock the final synthesized compounds with the telomerase protein to study regarding the pKi value using G-quadruplex ligand database (G4LDB). The docked results are visualized using Discovery Studio Visualizer 4.1. The results are compared with the standard N,N’-bis-(2-(1-piperidino)ethyl)-3,4,9,10-perylene tetracarboxylic acid diimide (PIPER) drug and these compounds will be effective for anticancer therapy.Methods: The study was to investigate the docking results of synthesized perylene compounds with the results from G4LDB and visualized by Discovery Studio 4.1 Visualizer. The telomerase proteins selected for the study were extracted from Protein Data Bank, and the proteins selected for the study are 3SC8 and 3CE5. Among the compounds (R1, R2, R3, and R4) screened in G-Quadruplex Ligand Database, compound R3 shows better binding affinity with good pKi value as well the interactions with the protein and ligand show better affinity with the targets and these are compared with the standard drug PIPER drug.Results: Compound R3 possesses the best binding affinity with the target 3CE5 and 3SC8 which shows that the compound will be effective for anticancer therapy.
A COMPENDIOUS REVIEW ON THE METABOLIC SYNDROME; ITS IMPACT ON THE QUALITY OF LIFE
Authors: V Rajalakshimi , M Vijey Aanandhi
Published: January 2019

Background: Metabolic syndrome (MetS), a comprehensive condition is universally described as a group of several causative factors or abnormalities directly linked with insulin resistance that obviously augment the threat mainly for coronary heart disease, diabetes mellitus Type 2, some types of cancers and sleep disturbances, etc. MetS is a contemporary condition that covers a wide-ranging display of disorders with definite metabolic anomalies demonstrating at different times. Consequently, the threat of MetS remains epidemic. This review will potentially study significant factors such as central adiposity, insulin resistance, hypertension, and dyslipidemia; increased inflammation, environmental factors, and genetic predisposition are involved in MetS development. Purpose: This review provides the available facts to validate the relationship between MetS and quality of life. Methods: A thorough exploration in many search engines such as PubMed, Medline, Science direct, EMBASE, and Google scholar was carried out to recognize qualified studies. Results: Almost all studies suggested that MetS is significantly associated with impair quality of life. Lifestyle intervention holds the early preference and such non-pharmacological therapy combines specific suggestion on diet and physical activity with behavioral strategies. For the individuals, where contributing factors are not sufficiently condensed with lifestyle changes, pharmacological treatment should be considered. Conclusion: Therefore, the current study reviews the outline of literature interrelated with the MetS’s characterization, epidemiological existence, pathological process, and management advance for all the risk factors encompassing metabolic disorder.
A PROSPECTIVE OBSERVATIONAL STUDY ON PATTERN OF ADVERSE DRUG REACTION TO ANTIBIOTICS COMMONLY PRESCRIBED IN THE HOSPITALIZED PEDIATRIC PATIENTS
Authors: Velraj, Malarkodi
Published: January 2019

Objective: Antibiotics are the almost usually specified or authorized medication in hospitals, and antibiotics were found to be the almost bothersome classes of drugs providing or endowing to adverse drug reactions (ADRs). Therefore, the present study was conducted to check or regulate the precautions (ADRs) of antibiotics usually specified or authorized in the pediatrics unit. Methods: A potential, experimental, non-interventionist study was conducted or executed in the Department of Pediatrics for a time of 6 months to analyze the ADRs reported spontaneously from the hospital using patient statistics, objective and medication information, data of ADRs, onset time, causal drug details, outcome, and severity. Results: Among 72 ADRs observed, beta-lactams and quinolones were set up to be contributing the highest number of ADRs. The duct or abdominal system was the almost commonly affected organ, followed by respiratory system and the cardiovascular system. The assessment by the World Health Organization causation estimation scale demonstrated that 5.56% ADRs were certain, 55.56% were possible, 30.56% were probable, and 8.33% were unlikely. Conclusion: Thus, the pattern of ADRs occurring in the pediatric population was observed and assessed. Early recognition and management of ADRs are essential to reduce the burden of ADRs
DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF TOPICAL GEL CONTAINING ITRACONAZOLE - ANTIFUNGAL AGENT
Authors: K Pavithra
Published: January 2019

Objective: The main purpose of this study was to develop a topical delivery of itraconazole to reduce the dose of the drug, to improve patient compliance, and to avoid the side effects. Itraconazole is a triazole derivative to treat antifungal and antiprotozoal infections. Methods: Topical gel formulations of itraconazole were prepared using Carbopol 940 as a gelling agent with different concentrations. Four different formulations were prepared and evaluated with respect to color, spreadability, viscosity measurement, determination of pH, drug content, in vitro drug release studies, zeta potential studies, and stability studies. Compatibility study was carried out by Fourier-transform infrared (FT-IR) spectral analysis. Results: FT-IR study revealed that there were no significant interaction between the drug and polymers. All the prepared formulations show acceptable physical properties. The drug content and percentage yield were higher for F1 formulation among all formulation F1 shows better drug release. Stability study of best formulation shows that there was no difference in drug content and in vitro drug release studies. Conclusion: From the above observation results that this formulation may be more encouraging topical substitute for the healing of fungal infections in the skin.
INCIDENCE OF POST-OPERATIVE ADR OF ANESTHETICS IN TERTIARY CARE TEACHING HOSPITAL: CLINICAL PHARMACIST PERSPECTIVES
Authors: M Ashok Kumar ,
Published: January 2019

Objective: The objective of the study was to evaluate the use of anesthetics in various general surgical conditions and to identify the adverse clinical outcomes of anesthetics in post-operative patients using questionnaire and verbal rating scale (VRS) score and to assess the treatment pattern of adverse clinical outcomes of anesthetics.Methods: A prospective study was carried out in the Inpatient Department of General Surgery and ICU in S.R.M Medical College Hospital and Research Center involving patients up to 65 years of age. A total of 160 patients were recruited for the study based on inclusion and exclusion criteria. Patient demographics, medical history, type of surgery, type of anesthetics, duration of anesthesia, ASA Grade physical status, system examination, general examination, vital signs, and anesthetics drugs were assessed using pro forma. Adverse clinical outcomes of anesthetics were assessed using VRS score. Day of incidence of adverse outcomes was also monitored, and management of post-operative side effects and its effectiveness were assessed.Results: During the study period, approximately 50% of the patient’s undergone general anesthetics reported post-operative pain. The incidence of post-operative nausea/vomiting, sore throat, and cough was highest in patient’s undergone general anesthetics. The adverse outcomes were measured by VRS score, showed that mild adverse outcomes were predominated.Conclusion: Patients who undergone general anesthetics developed high risk of adverse outcomes. The post-operative recovery of the patientwas the main challenge. If an adverse drug reaction is not monitored the patients satisfaction can be weakened in general surgery. Hence, it isconcluded that pharmacists can play a major role in assessing adverse clinical outcomes and its management.
CLINICAL EVALUATION OF MANAGEMENT AND PREVALENCE OF TYPE TWO DIABETES MELLITUS COMPLICATIONS IN SOUTH INDIAN POPULATION
Authors: P Geetha
Published: January 2019

Objective: The present study was aimed to assess the prevalence of complications and to assess the targets achieved during the management of diabetes mellitus type 2.Methods: The study was prospective and conducted out in a diabetes center, Chennai, ethical approval was obtained from the Institutional Ethics Committee, case records of the 300 patients diagnosed with type 2 diabetes mellitus and its complications were monitored during March 2017–April 2018. Major result actions are body weight, height, body mass index (BMI), blood pressure, fasting blood sugar (FBS), post-prandial blood sugar (PPBS) levels, glycosylated hemoglobin, serum lipids, and presence of complications of diabetes. Comparison of the average of various biochemical parameters was made in patients with and no diabetic complications.Results: The average age of 300 patients was found to be 55.006±13.04. The average BMI was 27.10±12.81 kg/m2. The average duration of diabetes was 10.48±7.53. The average of systolic (SBP) and diastolic blood pressure was 137±20.88 and 79.95±11.81. The mean glycated hemoglobin, FBS, PPBS, low-density lipoprotein, high-density lipoprotein, and triglyceride, and total cholesterol were found to be 8.5±3.99, 148.85±55.64 mg/dl, 200.98±72.63 mg/dl, 88.06±19.46 mg/dl, 36.20±8.27 mg/dl, 141.22±60.15 mg/dl, and 144.45±29.03 mg/dl, respectively. Among the microvascular complications; neuropathy, nephropathy, and retinopathy were documented in 8.33%, 23.66%, and 17.33% of patients, respectively. The prevalence of peripheral artery disease was 20.66%.Conclusion: The prevalence of diabetic complications is significantly increased with patients age, duration, SBP, low-density lipoprotein,total cholesterol, and post-prandial blood sugar levels. Knowledge concerning the supervision of target blood pressure and lipidparameters is need further than the glycemic manage among diabetes patients type two.
CEFTRIAXONE-INDUCED PERIORBITAL EDEMA
Authors: Nayak Veena , Somu Keerthi , Thomson Sereene Rose , Bs Sujatha
Published: January 2019

Cephalosporins are widely prescribed antibiotics for common infections and also used for prophylactic measures. Ceftriaxone is a third-generation cephalosporin which is known to cause hypersensitivity reactions presenting in various manifestations. Periorbital edema is a rare presentation of adverse drug reaction produced by ceftriaxone. Here, we report one such adverse drug reaction produced by ceftriaxone.