bluuebunny/crossref_metadata_2025 huggingface dataset:
Reglas y Advertencias Generales de Pablo Minguet (1754 y 1774): Estudio de sus diferentes ediciones y análisis de las pautas para la interpretación de la guitarra
Authors: Ventura Quintana Sakira
Published: March 2020

Dentro del corpus tan variado de publicaciones del editor catalán Pablo Minguet, destaca el tratado pedagógico-musical titulado Reglas y Advertencias Generales que enseñan el modo de tañer todos los instrumentos mejores, y mas usuales, como son la Guitarra, Tiple, Vandola, Cythara, Clavictordio, Organo, Harpa, Psalterio, Bandurria, Violin, Flauta Travesera, Flauta Dulce y la Flautilla. Este tratado formado por cuadernillos individuales fue concebido para aprender a tocar determinados instrumentos e interpretar su repertorio sin necesidad de maestro, pero para la Musicología actual supone una importante fuente de estudio y análisis de la panorámica organológica del Madrid a mediados del siglo XVIII.
Estrategias eficaces de práctica instrumental. Primeros pasos al estudiar una obra musical. Granada: Editorial Libargo, 162 pp. ISBN: 978-84-948136-6-5.
Authors: Seguí Montiel
Published: March 2020

Reseña de libro.
Adolf Arendt: postać ze Sklepów cynamonowych
Authors: Sypek Antoni
Published: March 2020

Adolf Arendt (1862-1932), nauczyciel rysunków odręcznych w galicyjskich gimnazjach, uważany jest za pierwszego nauczyciela rysunków Brunona Schulza w drohobyckim gimnazjum. Pisarz uczynił go jedną z postaci w Sklepach cynamonowych i, jak się okazuje, jest to jedyna postać w prozie Schulza, która miała swój realny i jednocześnie bezpośredni pierwowzór w rodzinnym mieście pisarza. Autor artykułu pieczołowicie rekonstruuje biografię rzeczywistego Arendta, opierając się na szczegółowych badaniach bibliograficznych oraz licznych kwerendach archiwalnych. Rekonstruując nieznane dotychczas fakty z jego życia, jednocześnie kreśli także szersze tło historyczne dzieła Schulza, uzupełniając dotychczasowe badania nad jego twórczością literacką i plastyczną.
Treny od 19 do 1: niedoskonałość i doskonałość
Authors: Marinelli Luigi
Published: March 2020

Artykuł stanowi ponowną próbę wyjaśnienia istoty cykliczności Trenów Jana Kochanowskiego w odniesieniu do ich kontekstów interpretacyjnych, w tym zwłaszcza Psałterza Dawidowego. Dokonując swej poetyckiej parafrazy Psalmów, Kochanowski mógł się zetknąć ze średniowieczną tradycją spekulacji symboliczno-arytmetycznej, co według autora dopuszcza możliwość lektury numerologicznej Trenów w ramach idei jedności humanitas / divinitas. Idea ta przybliża cykl żałobny Kochanowskiego zarówno do tradycji orficko-pitagorejskiej, wtopionej w humanistyczny neoplatonizm chrześcijański, jak i do podstawowych w chrześcijaństwie prawd chrystologicznych: w tej perspektywie niedoskonałość liczby 19 prowadzi do doskonałości liczby 1, oddającej prajednię (Giordano Bruno). Autor stara się przy tym udowodnić, że określona kolejność utworów w cyklu (na przykład szczególna pozycja numeru 11) wzmacnia i podbudowuje dramatyzm myśli poety, zmagającego się z osobistą katastrofą.
Presencia de alteraciones histopatológicas en vellosidades placentarias normales en Maracay (Venezuela)
Authors: Castejón-S. Olivar C. , López-G. Ángela J. , Pérez-Ybarra Luis M. , Castejón-M. Óliver C.
Published: March 2020

Objetivo: determinar la proporción de las alteraciones histopatológicas en las vellosidades y en el espacio intervelloso obtenida de cuatro placentas normales del último trimestre del embarazo.Metodología: por medio de la microscopía de luz y la tinción de hematoxilina y eosina (H&E) se identificaron, en 25 láminas de 5 regiones de la placenta, 6 variables cuantitativas (p.ej. inmadurez vellosa, nódulos sincitiales, cambios fibrinoides, edema velloso, fibrosis estromal y calcificación) y 9 variables cualitativas (p.ej. depósitos de fibrina, trombosis intervellosa, infartos, trombosis vascular, cambios en la pared del vaso, calcificación intraluminal, congestión vascular,inflamaciónyhemorragia).Los resultados de las variables cuantitativas se analizaron utilizando el Análisis de Varianza (ANAVAR) de 2 vías con submuestreo y el test de Tukey. En contraste, para las variables cualitativas se aplicó la prueba de Kruskal Wallis y se estimó el porcentaje de positividad según las regiones. Dichos análisis se realizaron por medio del software Statistix® 8.0 y SAS® 9.0 para Windows®.Resultados: no se presentaron diferencias significativas (p<0,05) entre las placentas más no entre las regiones. Del mismo modo, no se observó trombosis vascular, daño de la pared de lvaso,congestión vascular, calcificación intraluminal, inflamación ni hemorragia.Conclusión: las vellosidades analizadas se mostraron homogéneas dentro de cada placenta pero no entre las mismas, indicando una variabilidad que etiológicamente podría explicarse por factores genéticosyambientalesdecuyainteracciónresultarían las diferencias individuales para cada placenta.
BASE TREND ON NUMBER OF RUSSIAN ADOLESCENTS (AGED 15-17) REQUIRE FOR MEDICAL SUPERVISION IN 2000-2015 YEARS
Authors: Banteva Marina N. , Matveev E. N , Manoshkina E. M
Published: March 2020

The increase in the incidence of adolescents in Russia is confirmed by many special studies. An analysis of the statistic data for 2000-2015 years, showed that in Russia there was an increase in the number of adolescents (15-17 years) require for medical supervision from 410 to 486 cases per 1000 of the corresponding population (18.5%), however over the last 5 years, it declines (an average annual growth of -1.1%). The highest growth in 15 years was found in the following classes: neoplasms (126.7%), congenital anomalies (malformations) (57.6%), diseases of the musculoskeletal system and connective tissue (58.2%), diseases of the cardiovascular system (55.0%). The decrease in the number of adolescents (15-17 years) require for medical supervision for the indicated period was in three classes: some infectious and parasitic diseases (-68.2%), mental and behavioral disorders (-46.2%), injuries and poisonings (-20.8%). The balance of the number of the studied group of adolescents in 2015 was negative and amounted to -9.1% due to the excess of the number of people taken out of the register (39.0%) over the number of registered persons (48.1%), what indicates a decrease in the number of adolescents require for medical supervision. At the same time, a positive balance was observed only in two classes: injuries and poisonings (42.1%), pregnancy, deliver and puerperium (9.1%). Negative balance of the studied contingent was observed for all other classes of diseases, the highest ones: congenital anomalies (malformations) (-17.9%), mental and behavioral disorders (14.9%), respiratory diseases (-14, 2). Since the health of children and adolescents determines the health of the future nation, its preservation is an important task, the implementation of which requires the development of prophylaxis for the prevention of diseases with the definition of their targeted introduction (school, home, healthcare institutions), as well as treatment of diseases of children and adolescents, including, the format of special medical observation.
PROGNOSTIC SIGNIFICANCE OF COMORBIDITIES FOR FUNCTIONAL OUTCOME AFTER STROKE
Authors: Kostenko Elena V. , Kravchenko V. G , Gorshkov D. V
Published: March 2020

Concomitant diseases occupy an important place among prognostic predictors of functional recovery after stroke. The aim of the study was to study the features of concomitant morbidity in patients after ischemic stroke, to identify the leading comorbid pathology and its impact on the features of the rehabilitation process. Materials and methods. The study included 1317 patients with ischemic stroke, mean age 60.6±2.6 years. Results. It was revealed that the level of concomitant pathology was 391.5 cases per 100 patients among patients who underwent AI. Analysis of the incidence of comorbidities by disease classes allowed to establish that the first place belongs to diseases of the circulatory system, the second-mental diseases, the third-endocrine diseases. Conclusion. The presence of concomitant diseases should be taken into account when choosing a diagnostic algorithm, assessing the rehabilitation potential of the patient and drawing up a comprehensive individualized rehabilitation program.
THE VACCINE HESITANCY - THE NEW PLAGUE OF THE 21ST CENTURY
Authors: Volkova P. , Dubenskaya V. A , Marusina M. G , Polunin Valeriy S. , Turbina Y. O
Published: March 2020

For the first time in 2019, the World health organization (WHO) anked non-vaccination among the top 10 threats to humanity. Immunprevention, initiated by E. Jenner in 1796, became one of the greatest achievements of medicine, which nowadays annually prevents up to 3 million human deaths. Despite this fact, in recent years, society is increasing anti-vaccination sentiment, frequent cases of refusal of vaccination. The population’s attitude to vaccination has been analyzed and the main reasons for its rejection have been identified. By means of anonymous online survey the study involved 954 participant in the age range from 18 to 70 years. Participants have different levels of education, live throughout Russia and make decisions for themselves and for children in the matter of vaccination. The widespread lack of information about the purpose of the vaccination, its complications and the vaccine controlled infection have been indicated. Actually, mothers are most vulnerable to doubts about their children’s vaccination - 115 women give up all vaccinations. Many respondents (59 respondents) point to distrust of doctors as a reason for refusal of vaccination. More over, adults are not aware of the need for revaccination at all. There are a significant lack of health education and public distrust of health workers. Finally, methods to increase the population’s commitment to vaccination have been developed, aimed to overcome unfounded fears about vaccination and to improve the status of health workers.
Separata sección filosofía de la educación y enseñanza de la filosofía
Authors: Cultural Margen Visual Corporación Artística y
Published: March 2020

Separata sección filosofía de la educación y enseñanza de la filosofía
Separata sección Filosofía analítica y pragmatismo
Authors: Margen  Visual Corporación Artística y Cultural
Published: March 2020

Separata sección Filosofía analítica y pragmatismo
The Complexity of Number Theory
Authors: Vega Frank
Published: March 2020

The Goldbach's conjecture has been described as the most difficult problem in the history of Mathematics. This conjecture states that every even integer greater than 2 can be written as the sum of two primes. This is known as the strong Goldbach's conjecture. The conjecture that all odd numbers greater than 7 are the sum of three odd primes is known today as the weak Goldbach conjecture. A major complexity classes are L, NL and NSPACE(S(n)) for some S(n). Whether L = NL is a fundamental question that it is as important as it is unresolved. We show if the weak Goldbach's conjecture is true, then the problem PRIMES is not in NSPACE(S(n)) for all S(n) = o(log n). This proof is based on the assumption that if some language belongs to NSPACE(S(n)), then the unary version of that language belongs to NSPACE(S(log n)) and vice versa. However, if PRIMES is not in NSPACE(S(n)) for all S(n) = o(log n), then the strong Goldbach's conjecture is true or this has an infinite number of counterexamples. Since Harald Helfgott proved that the weak Goldbach's conjecture is true, then the strong Goldbach's conjecture is true or this has an infinite number of counterexamples, where the case of infinite number of counterexamples statistically seems to be unlikely. In addition, if PRIMES is not in NSPACE(S(n)) for all S(n) = o(log n), then the Beal's conjecture is true when L = NL. On November 2019, Frank Vega proves that L = NP which also implies that L = NL. In this way, the Beal's conjecture is true and since the Beal's conjecture is a generalization of Fermat's Last Theorem, then this is also a simple and short proof for that Theorem.
Dynamics of Large Scale Turbulence in Finite-sized Wind Farm Canopy using Proper Orthogonal Decomposition and a Novel Fourier-POD Framework
Authors: Chatterjee Tanmoy , Peet Yulia T.
Published: March 2020

Large scale coherent structures in atmospheric boundary layer (ABL) are known to contribute to the power generation in wind farms. In the current paper, we perform a detailed analysis of the large scale structures in a finite sized wind turbine canopy using modal analysis from three dimensional proper orthogonal decomposition (POD). While POD analysis sheds light on the large scale coherent modes and scaling laws of the eigenspectra, we also observe a slow convergence of the spectral trends with the available number of snapshots. Since the finite sized array is periodic in the spanwise direction, we propose to adapt a novel approach of performing POD analysis of the spanwise/lateral Fourier transformed velocity snapshots instead of the snapshots themselves. This methodology not only helps in decoupling the length scales in the spanwise and the streamwise direction when studying the energetic coherent modes, but also provides a detailed guidance towards understanding the convergence of the eigenspectra. In particular, the Fourier-POD eigenspectra helps us illustrate if the dominant scaling laws observed in 3D POD are actually contributed by the laterally wider or thinner structures and provide more detailed insight on the structures themselves. We use the database from our previous large eddy simulation (LES) studies on finite-sized wind farms which uses wall-modeled LES for modeling the Atmospheric boundary layer laws, and actuator lines for the turbine blades. Understanding the behaviour of such structures would not only help better assess reduced order models (ROM) for forecasting the flow and power generation but would also play a vital role in improving the decision making abilities in wind farm optimization algorithms in future. Additionally, this study also provides guidance for better understanding the POD analysis in the turbulence and wind farm community.
What are the Impacts of Sugarcane Production on Ecosystem Services? A Review
Authors: EL CHAMI Daniel , DACCACHE André , EL MOUJABBER Maroun
Published: March 2020

Since the 1950s sugarcane production has grown rapidly from less than 0.5 billion tonnes in the late 50s to reach over 1.9 billion tonnes in 2012 on about 27 million hectares of agricultural land. This expansion has been boosted by the high demand for bioethanol promoted as a sustainable bioenergy source which accounted in 2010 for the biggest share of the global biofuel market. Despite its benefits, the scientific debate on sugar is growing especially that counterarguments are so many, including negative impacts on different interacting ecosystems and human well-being, e.g. bigger stress on land and water resources, environmental externalities on air, a harmful impact on the biodiversity and endemic species, negative environmental externalities, health, and socio-economic aspects. This paper provides a narrative systematic review (SR) of the impacts of sugarcane production on these different ecosystems employing the ecosystem services framework for its acceptance by policy-makers. The references included for the SR were 163 and results showed that the majority of the studies are from Brazil, Australia, South Africa and the USA (≈ 75% of the literature), most of them were from peer-reviewed journals (85%), and most of the case studies adopted a quantitative research approach (93%). The literature assessed showed that sugarcane, like all agro-systems, depends on the practices and techniques to transform negative impacts into positive externalities on ecosystems and human well-being. However, the literature studied failed to include the inter-linkage in sugarcane production impacts’ and therefore to evaluate the related ecosystem services with respect to the Millennium Ecosystem Assessment (MA) framework to account for existing trade-offs. Therefore, the findings are addressed to the scientific community and decision-maker for an intensification of interdisciplinary and integrated research based on the MA framework to cover all ecosystem services, for sustainable development of the sugarcane sector.
Engineered Durum Wheat Germplasm with Multiple Alien Introgressions: Agronomic and Quality Performance
Authors: Kuzmanović Ljiljana , Rossini Francesco , Ruggeri Roberto , Pagnotta Mario A. , Ceoloni Carla
Published: March 2020

If genetic gains in wheat yield are to be achieved in today’s breeding, increasing genetic variability of cultivated genotypes is an essential requisite to meet. To this aim, alien gene transfer through chromosome engineering (CE) is a validated and sound strategy. Attempts to incorporate more than one alien segment into cultivated wheat have been rare, particularly for tetraploid durum wheat. Here we present the agronomic and quality performance of the first successful CE-mediated multiple introgression into the latter species. By assembling into 7AL, 3BS and 1AS arms of a single genotype homoeologous segments of Thinopyrum ponticum 7el1L, Aegilops longissima 3SlS, and Triticum aestivum 1DS arms, respectively, we have stacked several valuable alien genes, comprising Lr19+Sr25+Yp (leaf and stem rust resistance and a gene increasing semolina yellowness), Pm13 (powdery mildew resistance) and Gli-D1/Glu-D3 (genes affecting gluten properties), respectively. Advanced progenies of single, double and triple recombinants were field-tested across three years in a typical durum wheat growing area of Central Italy. The results showed that not only all recombinants had normal phenotype and fertility, but also that one of the triple recombinants had the highest yield through all seasons compared with all other recombinants and control cultivars. Moreover, the multiple introgressions enhanced quality traits, including gluten characteristics and semolina yellow index. Presence of effective disease resistance genes confers additional breeding value to the novel and functional CE products, which can greatly contribute to crop security and safety.
Current Trends and Confounding Factors in Myoelectric Control: Limb Position and Contraction Intensity
Authors: Campbell Evan , Phinyomark Angkoon , Scheme Erik
Published: March 2020

Myoelectric control is the cornerstone of many assistive technologies used in clinical practice, such as prosthetics and orthoses, and human-computer interaction, such as virtual reality control. Although the performance of such devices exceeds 90\% in controlled environments, myoelectric devices still face challenges in robustness to variability of daily living conditions. Within this survey, the intrisic physiological mechanisms limiting practical implementations of myoelectric devices were explored: the limb position effect and the contraction intensity effect. The degradation of electromyography (EMG) pattern recognition in the presence of these factors was demonstrated on six datasets, where performance was 13% and 20% lower in realistic environments compared to controlled environments for the limb position and contraction intensity effect, respectively. The experimental designs of limb position and contraction intensity literature were surveyed. Current state-of-the-art training strategies and robust algorithms for both effects were compiled and presented. Recommendations for future limb position effect studies include: the collection protocol providing exemplars of 6 positions (four limb positions and three forearm orientations), three-dimensional space experimental designs, transfer learning approaches, and multi-modal sensor configurations. Recommendations for future contraction intensity effect studies include: the collection of dynamic contractions, nonlinear complexity features, and proportional control.
Ciclopirox Olamine Induces Ferritinophagy and Ameliorates Disease Progression in Polycystic Kidney Disease
Authors: Radadiya Priyanka S. , Puri Rajni V. , Magenheimer Brenda , Subramaniam Dharmalingam , Tran Pamela V. , Zhu Hao , Bolisetty Subhashini , Calvet James P. , Wallace Darren P. , Sharma Madhulika
Published: March 2020

Despite the recent launch of Tolvaptan, the search for safer polycystic kidney disease (PKD) drugs continues. Ciclopirox, as the free acid (CPX) and its olamine salt (CPX-O) , are contained in number of commercially available topical antifungal agents. CPX is reported in the literature to possess anticancer activity in number of solid tumor cancers and hematological malignancy by several proposed mechanisms of action including chelation of iron and inhibition of iron dependent enzymes. Here, we show that CPX-O inhibited in vitro cystogenesis of primary human cyst epithelial cells cultured in 3D collagen matrix. To determine if CPX-O inhibits PKD progression, we treated PKD mice with a low dose of 10 mg/kg CPX-O by daily intraperitoneal injections from day 21 to day 49 post- partum. CPX-O reduced the kidney to body weight ratio of the PKD mice. This was associated with decreased cell proliferation decrease cystic area and improved renal function. We found that ferritin levels were significantly elevated in cystic kidneys of PKD mice, and that CPX-O treatment reduced renal ferritin levels and increased ferritinophagy marker, NCOA4. Our data suggest that CPX-O dose dependently induces ferritin degradation via ferritinophagy which is associated with decreased cyst growth and disease progression in PKD mice. Most importantly these data indicate that CPX-O, a drug used to treat skin infections and currently in clinical trials for cancer, has the potential to treat ADPKD.
Job Opening for Nucleosome Mechanic: Flexibility Required
Authors: Pitman Mary , Melters Daniël P. , Dalal Yamini
Published: March 2020

The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer's mechanical properties. In recent years, innovative work deploying interdisciplinary approaches including computational modeling, in vitro manipulations of purified and native chromatin have resulted in deep mechanistic insights into how the mechanics of chromatin might contribute to its function. The picture that emerges is one of a nucleus that is shaped as much by external forces pressing down upon it, as internal forces pushing outwards from the chromatin. These properties may have evolved to afford the cell a dynamic and reversible force-induced communication highway which allows rapid coordination between external cues and internal genomic function.
De novo Transcriptome Assembly and Annotation of Liver and Brain Tissues of New Zealand brushtail possums (Trichosurus vulpecula): Transcriptome Diversity after Decades of Population Control
Authors: Emami-Khoyi Arsalan , Parbhu Shilpa , Ross James , Murphy Elaine , Bothwell Jennifer , Monsanto Daniela , Van Vuuren Bettine , Teske Peter , Paterson Adrian
Published: March 2020

The New Zealand brushtail possum (Trichosurus vulpecula), introduced from Australia in the 1850s, is an invasive species that is widespread throughout New Zealand and forms the largest self-sustained reservoir of bovine tuberculosis (Mycobacterium bovis) in the wild. Conservation and agricultural authorities regularly apply a series of population control measures to suppress brushtail possum populations. The evolutionary consequence of more than half a century of intensive population control operations on the species genomic diversity and population structure is hindered by a paucity of available genomic resources for the species. This study is the first to characterise the functional content and diversity of brushtail possum liver and brain cerebral cortex transcriptomes. Raw sequences from hepatic cells and cerebral cortex were assembled into 58,001 and 64,735 transcripts in hepatic cells and cerebral cortex, respectively. Functional annotation and polymorphism assignment of the assembled transcripts demonstrated a considerable level of variation in the core metabolic pathways that represent potential targets for selection pressure exerted by chemical toxicants. This study suggests that the brushtail possum population in New Zealand harbours considerable levels of variation in metabolic pathways that could potentially promote the development of tolerance against chemical toxicants.
Updated European Hydraulic Pedotransfer Functions with Communicated Uncertainties in the Predicted Variables (euptfv2)
Authors: Szabó Brigitta , Weynants Melanie , Weber Tobias KD
Published: March 2020

Soil hydraulic properties are often derived indirectly, i.e. computed from easily available soil properties with pedotransfer functions (PTFs), when those are needed for catchment, regional or continental scale applications. When predicted soil hydraulic parameters are used for the modelling of the state and flux of water in soils, uncertainty of the computed values can provide more detailed information when drawing conclusions. The aim of this study was to update the previously published European PTFs (Tóth et al., 2015, euptf v1.4.0) by providing prediction uncertainty calculation built into the transfer functions. The new set of algorithms was derived for point predictions of soil water content at saturation (0 cm matric potential head), field capacity (both -100 and -330 cm matric potential head), wilting point (-15.000 cm matric potential head), plant available water, and saturated hydraulic conductivity, as well as the Mualem-van Genuchten model parameters of the moisture retention and hydraulic conductivity curve. The minimum set of input properties for the prediction is soil depth and sand, silt and clay content. The effect of including additional information like soil organic carbon content, bulk density, calcium carbonate content, pH and cation exchange capacity were extensively analysed. The PTFs were derived adopting the random forest method. The advantage of the new PTFs is that they i) provide information about prediction uncertainty, ii) are significantly more accurate than the euptfv1, iii) can be applied for more predictor variable combinations than the euptfv1, 32 instead of 5, and iv) are now also derived for the prediction of water content at -100 cm matric potential head and plant available water content.
Influence of Cross Section Thickness and Aspect Ratio on Deformation during Diffusion Bonding and Impact of Metal Diffusion and Evaporation on Temperature Measurement Accuracy
Authors: Gietzelt Thomas , Toth Volker , Kraut Manfred , Gerhards Uta , Duerrschnabel Robin
Published: March 2020

Diffusion bonding is often used on pre-machined parts to generate internal cavities, e.g. for cooling injection molding tools close to the mold cavity. Only then, the workpieces are finished to their final dimensions. In the case of micro-process devices, however, it is essential to precisely control the deformation, as otherwise uncontrollable pressure losses will occur with channel cross-sections in the sub-millimeter range. Post-processing is not possible. The most important process parameters for diffusion bonding are temperature, dwell time and contact pressure, with the bonding temperature and contact pressure acting in opposite directions and showing a strong non-linear dependence on deformation. In addition, the deformation is influenced by a number of other factors such as the absolute size of the cross-section and the aspect ratio of the parts, the dimensions and distribution of the internal cross sections and the overall percentage of the cross-section to be bonded. In micro process engineering, small material cross-sections in the range of the materials microstructure can facilitate additional deformation mechanisms such as grain boundary sliding, which are not relevant at all for larger structures. For parts consisting of multiple layers, tolerances in thickness and roughness of multiple surfaces must be levelled, contributing to the percentaged deformation. This makes it difficult, especially in micro process engineering and in single or small series production, to determine suitable joining parameters in advance, which on the one hand do not cause unforeseen large deformations, but on the other hand reliably produce highly vacuum-tight components. Hence, a definition of a fixed percentaged deformation does not work for all kinds of components. This makes it difficult to specify parameters for surely obtain high-vacuum tight parts. For successful diffusion bonding, atoms must diffuse over the bonding planes, forming a monolithic part in which the original layers are no longer visible. Only then, mechanical properties identical to those of the base material, which has been subjected to identical heat treatment, can be achieved. In this paper, the impacts of different material cross section widths as well as of the aspect ratio on deformation were investigated. By accident, it was found that also accuracy of the temperature measurement may have a serious impact in terms of deformation.
Clonal Structure, Virulence Factor-Encoding Genes and Antibiotic Resistance of Escherichia coli Causing Urinary Tract Infections and Other Extraintestinal Infections in Humans in Spain and France During 2016
Authors: Flament-Simon Saskia-Camille , Nicolas-Chanoine Marie-Hélène , García Vanesa , Duprilot Marion , Mayer Noémie , Alonso María Pilar , García-Meniño Isidro , Blanco Jesús Eulogio , Blanco Miguel , Blanco Jorge
Published: March 2020

Escherichia coli is the main pathogen responsible for extraintestinal infections. A total of 196 clinical E. coli consecutively isolated during 2016 in Spain (100 from Lucus Augusti hospital in Lugo) and France (96 from Beaujon hospital in Clichy) were characterized. Phylogroups, clonotypes, sequence types (STs), O:H serotypes, virulence factor (VF)-encoding genes and antibiotic resistance were determined. Approximately 10% of the infections were caused by ST131 isolates in both hospitals and approximately 60% of these infections were caused by isolates belonging to only 10 STs (ST10, ST12, ST58, ST69, ST73, ST88, ST95, ST127, ST131, ST141). ST88 isolates were frequent especially in Spain while ST141 isolates significantly predominated in France. The 23 ST131 isolates displayed four clonotypes: CH40-30, CH40-41, CH40-22 and CH40-298. Only 13 (6.6%) isolates were carriers of ESBL enzymes. However, 37.2% of the isolates were multidrug-resistant (MDR). Approximately 40% of the MDR isolates belonged to only four of the dominant clones (B2-CH40-30-ST131, B2-CH40-41-ST131, C-CH4-39-ST88 and D-CH35-27-ST69). Among the remaining MDR isolates two isolates belonged to B2-CH14-64-ST1193 i.e the new global emergent MDR clone. To our knowledge, it is the first identification of this emergent clone in Spain. Moreover, a hybrid ExPEC/enteroaggregative isolate belonging to A-CH11-54-ST10 clone was identified.
Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane
Authors: Wijesinghe Kaveesha J. , McVeigh Luke , Husby Monica L. , Bhattarai Nisha , Ma Jia , Gerstman Bernard S. , Chapagain Prem P. , Stahelin Robert V.
Published: March 2020

Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host cell plasma membrane. VP40 traffics to the plasma membrane inner leaflet, where it assembles to facilitate the budding of viral particles. VP40 is a multifunctional protein that interacts with several host proteins and lipids to complete the viral replication cycle, but many of these host-interactions remain unknown or are poorly characterized. In this study, we investigated the role of a hydrophobic loop region in the carboxy-terminal domain (CTD) of mVP40 that shares sequence similarity with the CTD of Ebola virus VP40 (eVP40). These conserved hydrophobic residues in eVP40 have been previously shown to be critical to plasma membrane localization and membrane insertion. An array of cellular experiments and confirmatory in vitro work strongly suggests proper orientation and hydrophobic residues (Phe281, Leu283, and Phe286) in the mVP40 CTD are critical to plasma membrane localization. In line with the different functions proposed for eVP40 and mVP40 CTD hydrophobic residues, molecular dynamics simulations demonstrate large flexibility of residues in the EBOV CTD whereas conserved mVP40 hydrophobic residues are more restricted in their flexibility. This study sheds further light on important amino acids and structural features in mVP40 required for its plasma membrane localization as well as differences in the functional role of CTD amino acids in eVP40 and mVP40.
Effects of Volume Fraction and Surface Area of Aggregates on the Static Yield Stress and Structural Build-Up of Fresh Concrete
Authors: Ivanova Irina , Mechtcherine Viktor
Published: March 2020

With increasing interest in the use of additive manufacturing techniques in the construction industry, static rheological properties of fresh concrete have necessarily come into focus. In particular, the knowledge and control of static yield stress (SYS) and its development over time are crucial for mastering formwork-free construction, e.g. by means of layered extrusion. Furthermore, solid understanding of the influences of various concrete constituents on the initial SYS of the mixture and the structural build-up rate is required for purposeful material design. This contribution is concentrated on the effect of aggregates on these rheological parameters. The volume fraction of aggregates was varied in the range of 35 to 55 % by volume under condition of constant total surface area of the particles. The total surface area per unit volume of cement paste was equal to 5.00, 7.25 and 10.00 m²/l, conditioned on the constant volume fraction of aggregates. Both variations were enabled by changing the particle size distributions of the aggregates while holding the cement paste composition constant for all concrete mixtures. To characterise the SYS and the structural build-up, constant shear rate tests with a vane-geometry rotational rheometer were performed. It was found that in the ranges under investigation the variation in volume fraction had a more pronounced effect on the static rheological properties of concrete than did the variation in surface area. An accurate mathematical description of the relationship between the initial SYS of concrete and the relative volume fraction of aggregate based on the Chateau-Ovarlez-Trung model was proposed. Challenges in deriving a similar relationship for the structural build-up rate of concrete were highlighted.
Tunable Photodetectors via in Situ Thermal Conversion of TiS3 to TiO2
Authors: Ghasemi Foad , Frinsenda Riccardo , Flores Eduardo , Papadopoulos Nikos , Biele Robert , Perez de Lara David , van der Zant Herre S. J. , Watanabe Kenji , Taniguchi Takashi , D’Agosta Roberto , Ares Jose R. , Sanchez Carlos , Ferrer Isabel J. , Castellanos-Gomez Andres
Published: March 2020

In two-dimensional materials research, oxidation is usually considered as a common source for the degradation of electronic and optoelectronic devices or even device failure. However, in some cases a controlled oxidation can open the possibility to widely tune the band structure of 2D materials. In particular, we demonstrate the controlled oxidation of titanium trisulfide (TiS3), a layered semiconductor that attracted much attention recently thanks to its quasi-1D electronic and optoelectronic properties and its direct bandgap of 1.1 eV. Heating TiS3 in air above 300 °C gradually converts it into TiO2, a semiconductor with a wide bandgap of 3.2 eV with applications in photo-electrochemistry and catalysis. In this work, we investigate the controlled thermal oxidation of individual TiS3 nanoribbons and its influence on the optoelectronic properties of TiS3-based photodetectors. We observe a step-wise change in the cut-off wavelength from its pristine value ~1000 nm to 450 nm after subjecting the TiS3 devices to subsequent thermal treatment cycles. Ab-initio and many-body calculations confirm an increase of the bandgap of titanium oxysulfide (TiO2-xSx) when increasing the amount of oxygen and reducing the amount of sulfur.
Assessing Sustainability Performance at the Farm Level: Examples from Greek Agricultural Systems
Authors: Tzouramani Irene , Mantziaris Stamatis , Karanikolas Pavlos
Published: March 2020

In recent years, farmers and policymakers have faced ample challenges and have struggled to support the sustainability of the agricultural sector. Sustainable agriculture encompasses multiple concepts, and its performance produces extensive debate about data requirements, appropriate indicators, evaluation methods, and tools. Under the European Union (EU) financed project FLINT (Farm Level Indicators for New Topics in policy evaluation), detailed data have been collected at the farm level to provide broader coverage of sustainability indicators on a wide range of relevant topics to facilitate the assessment of sustainability performance. The approach has been applied in a pilot network of representative farms at the EU level, considering the heterogeneity of the EU farming sector to provide data infrastructure with up to date information for sustainability indicators. This study aims to assess sustainability performance at the farm level in Greece. Representative and dominant agricultural systems, such as permanent crops, olive trees, arable crops, and livestock (sheep) farms, comprise the Greek sample. It uses the analytical hierarchy process (AHP) methodology and attempts to gain insights into the sustainability performance of agricultural systems. The outcome of the sustainability assessment reveals knowledge and develops support for strategic farm choices in order to support both farmers and policymakers towards more sustainable development plans. The results indicate that three typical Mediterranean farming systems, like permanent crops, olive trees, and extensive livestock systems (sheep farms), are more sustainable in contrast to intensive and arable crop farms.
Integrated BIM-Based LCA for the Entire Building Process Using an Existing Structure for Cost Estimation
Authors: Naneva Anita , Bonanomi Marcella , Hollberg Alexander , Habert Guillaume , Hall Daniel
Published: March 2020

The building sector has a big potential to reduce the material resource demand needed for building construction and therefore, greenhouse gas (GHG) emissions. Digitalisation can help to make use of this potential and improve sustainability throughout the entire building’s life cycle. One way to address this potential is through the integration of Life-Cycle Assessment (LCA) into the building process by employing Building Information Modelling (BIM). BIM can reduce the effort needed to carry out an LCA and therefore facilitate the integration into the building process. A review of current industry practice and scientific literature shows two main approaches to address BIM-LCA integration. Either the LCA is performed in a simplified way at the beginning of the building process, or it is done at the very end when all the needed information is available, but it is too late for decision-making. One reason for this is the lack of methods, workflows and tools to implement BIM-LCA integration over the entire building process. Therefore, the main objective of this study is to develop an integrated BIM-LCA workflow implemented into a method for the whole building process using an existing structure for cost estimation. A tool is created and used in a case study in Switzerland to test the developed approach. The results of this study show that LCA can be performed continuously in each building phase over the entire building process using existing BIM modelling techniques. The main benefit of this approach is that the re-work caused by the need for re-entering data and the usage of many different software tools that characterise most of the current LCA practices is minimised. Furthermore, decision-making, both at the element and building levels, is supported.
Educational method to investigarte the Relationship between Organizational Climate and Deviant Behaviors with the Mediation of Job Alienation Variable (Case Study: National Iranian Copper Industries Company)
Authors: Amin Farahbakhsh Amin , Salajeghe Sanjar , Ziaaddini Mohammad
Published: March 2020

Regarding the size and dispersion of the complex of copper factories in Iran and the high annual costs of preventing employees' strikes and also reducing deviant behaviors, and the existence of appropriate organizational climate, the aim of the present article is to find an educational method to investigate the relationship between organizational climate and deviant behaviors with the mediation of job alienation variable. This research is applied in terms of purpose, and in terms of nature, it is descriptive-correlation and it was conducted in field method. The statistical population of the research was the employees of the National Iranian Copper Industries Company (1010 people) whom are tried to educate this method. The sample size was calculated using the Cochran formula and 278 individuals were selected by simple random sampling. For data collection, the questionnaire of the organizational climate of Sasman and (Dalal, 2005), the adapted questionnaire of deviant behaviors of (Yoon Goo et al, 2013), and the questionnaire of job alienation of (Rahimi et al, 2016) were used. The reliability of the questionnaires in this research was respectively calculated as 0.851, 0.724, and 0.757. For data analysis, the Pearson correlation coefficient, multiple regression and, path analysis tests were used. The results indicated a positive and significant relationship between organizational climate and deviant behaviors, a negative and significant relationship between job alienation and deviant behaviors, and also explaining about 45% of deviant behaviors by organizational climate variables. It can be said that managers' attention to increase positive organizational climate and to decrease employees' job alienation can lead to further reduction of employees' deviant behaviors.
Chylous Leak During Posterior Approach to Juvenile Scoliosis Surgery
Authors: Shah Harsh A. , Rynecki Nicole , Vives Michael J. , Choi Daniel E. , Sambol Justin T. , Sabharwal Sanjeev
Published: March 2020

Case:

We report the first documented case of chylous leak recognized intraoperatively during posterior spinal instrumentation and fusion for juvenile scoliosis in a female patient with a history of thoracotomy and decortication for an empyema.

Conclusions:

Thoracic duct injury can lead to severe morbidity and mortality because of chylothorax formation. Although chylous leaks are a well-documented complication of the anterior approach to spine surgery, leaks during the posterior approach are rarely reported. When these chylous leaks are recognized intraoperatively, the likelihood of serious complications may be minimized by drain placement before closure.
Monitoring Lotic Ecosystem by the Application of Water Quality Index (CCMEWQI)
Authors: Et al. Salman
Published: March 2020

Water Quality Index (WQI) as a tool to assess the water quality status provides advice related to the use of water quality monitoring data and it is a way for combining the complex water quality data into a single value or single statement.The present study was conducted on Al- Hilla river in the middle of Iraq from August 2012 to July 2013 at five selected stations in the river, from Al- Musaib city to Al- Hashimya at the south of Hilla to determine its suitability for aquatic environment (GWQI), drinking water (PWSI) and irrigation (IWQI).This index offers a useful representation of the overall quality of water for public or any intended use as well as indicating pollution, water quality management, and decision making. According to the obtained results, it can be concluded that the EC, TSS, Total hardness, Ca, Mg, DO, BOD5, and NO3 moved away from the desired standards when the temperature rises. The variable of value of this index may be due to increasing the ration of organic matters and converting the carbonate to bicarbonate. The results recorded high value of calcium and magnesium more than the standard value of WHO and IQS (50 mg/l and high value of total hardness more than 500 mg/l). Irrigation water quality index (IWQI) in the study sites were ranged between 66-83 ranged between fair and good.
The Effect of Alcoholic and Aqueous Extract of Piper nigrum on the Larvae of Culex pipiens molestus Forskal (Diptera:Culicidae)
Authors: Yaseen Aulfat T.
Published: March 2020

The present study includes the effect of the ethanolic and aqueous extract of Piper nigrum against the third instar of Culex pipiens molestus (Diptera:Culicidae) in different concentrations: 1, 1.5 ppm of ethanolic extracts of Piper nigrum causing 100% mortality of larvae in the second day of treatment, while the concentrations 5% of aqueous extracts of Piper nigrum caused 100% mortality of larvae in the second day of treatment. The concentration 2.5% caused 100% mortality of larvae after four days of treatment. The current study also detected the effect of 0.1% concentration of Piper nigrum aqueous extract. The effect of this concentration has been studied on the growth of the ovaries and their follicles along a period 96 hours after emergence of adult life. The results of this study has clearly shown that the concentration 0.1% of Piper nigrum aqueous extract gave a highly significant inhibitory effect on the growth development of the ovaries and their follicles.
The Biofilm Inhibitory Potential of Compound Produced from Chlamydomonas reinhardtii Against Pathogenic Microorganisms
Authors: Et al. A.
Published: March 2020

Microalgae present much usefulness for antimicrobial research because of its enormous biodiversity and rapid growth rate. From this study results it is reaveled that Chlamydomonas reinhardtii were isolated from a pond of water in the province of Diwaniyah. The culture supernatants were obtained when extracted with methanol solvent. Antimicrobial activity of extracts was tested for pathogens, and the best inhibition zone obtained was against Candida albicans (32mm), S.aureus (15mm), and to E.coli (9mm). While it showed no effect against both S.epidermidis and Klebsiella spp. Biofilm was formed by all tested isolates with differences in its strength formation. The C. reinhardtii Algal extract showed higher reduction of the existing Staphylococcus aureus biofilm and (10.9 %) was the remaining biofilm, while 55.21% and 54.98% were to Serratia spp. and Escherichia coli respectively, and it’s the lowest reduction. Klebsiella spp., Candida albicans, Acinetobacter spp., Staphylococcus epidermides, and Aspergillus sp. showed remaining biofilm as (16.7, 18.3, 19.6, 43.6, and 44.1) % respectively. The composition of the volatile compounds of the C. reinhardtii extract was determined by GC/MS. Different groups of compounds were identified   such as hydrocarbons, phenols, alcohols and esters, and two bioactive compounds;1-Heptacosanol and Octadecyl chloride which is used in medical and pharmaceutical fields.These results provide an indication of the existence of hopeful antibiofilm compounds in the algal species under study. Further chemical studies are required to illuminate these compounds, structures and activity.