bluuebunny/crossref_metadata_2025 huggingface dataset:
Primary infective endocarditis with isolated involvement of the pulmonary valve not associated with drug addiction
Authors: Chipigina N. S. , Karpova N. Yu. , Tulinov M. M. , Golovko E. V. , Goloukhova L. M. , Kornienko V. S. , Kostin A. Yu. , Barsegyan V. A.
Published: August 2019

Objective: to describe a rare case of infective endocarditis (IE) with isolated localization in the pulmonary valve (PV).

Materials and methods. We observed primary IE with isolated localization in the PV in a 27-year-old female patient without risk factors of right-side IE.

Results. The disease was caused by Streptococcus gordonii and proceeded acutely with typical signs of right-side IE: fever above 38 °С, chills, clinical picture of bilateral septic embolic abscess pneumonia, as well as secondary anemia, secondary thrombocytopenia, and glomerulonephritis. Echocardiography showed large vegetations in the PV prolapsing in the right ventricle and pulmonary artery.

Conclusion. IE with localization in the PV should be suspected in patients with fever and clinical picture of septic embolic pneumonia in absence of other embolic situations.
A clinical case of systemic amyloidosis in a cardiologists’s practice
Authors: Okorokov V. G. , Evsina O. V. , Fomina V. A. , Ivanova G. O. , Soldatov E. S. , Dianov D. V. , Tkachenko K. A. , Ganyuta A. V.
Published: August 2019

The aimof the work was to study the clinical case of systemic amyloidosis.

Materials and methods. Patient Ch., 63 уears old, have admitted to the regional cardiological dispensary with complaints of short stabbing pains in the heart, without reaction to nitroglycerin, interruptions in the work of the heart, mainly at night, shortness of breath with little exertion, weakness, swelling of the legs and feet in September 2018. Sick from April 2016, when was dyspnea on exertion. The high level of creatinine, normochromic anemia have detected. In June 2016 chronic pyelonephritis was diagnosed. In August 2018, a right-sided hydrothorax was diagnosed, a pleural puncture was performed.

Results. Laboratory and instrumental research methods were performed. Based on anamnesis data (normochromic anemia, proteinuria, increased creatinine in the blood), clinical picture, data of instrumental studies (restrictive cardiomyopathy, bilateral hydrothorax) clinical diagnosis was made: systemic amyloidosis the kidneys and heart with chronic kidney disease C5 and chronic heart failure. Histological evidence of amyloid and determination of the variant of amyloidosis by immunohistochemical method was recommended. But the patient died before the study. The histological verification of the diagnosis was carried out at the autopsy.

Conclusion.This clinical observation is an example of late diagnosis of systemic amyloidosis and postmortal verification of the diagnosis, which is associated with the nonspecific symptoms and the rapidly progressing course of the disease. This case is interesting because amyloidosis proceeded under the guise of other diseases, quickly led to the development of severe heart and renal failure and to the death of the patient before verifying the disease.
Atypical clinical picture of waldenström’s macroglobulinemia: a difficult path to diagnosis
Authors: Makhnyr’ E. F. , Shostak N. A. , Inasaridze N. O. , Chernaya E. V.
Published: August 2019

Objective.To describe the difficulties of diagnosis of Waldenström macroglobulinemia in a patient with atypical clinical picture.

Materials and methods.Patient K., 57 years old, came in outpatient department with complaints of unilateral increase in submandibular lymph nodes on the right, discomfort in the nasopharynx, cough without sputum, increased fatigue. During the examination she was consulted by: an infectious disease specialist, otolaryngologist, surgeon, dentist, phthisiologist, hematologist and oncologist consulted her. To confirm the diagnosis conducted diagnostic activities: dynamic assessment of laboratory parameters, examination program cancer search (including multislice computed tomography and magnetic resonance imaging of various areas), with the exception of tuberculosis, monogenically study proteins in the blood and urine tests, biopsy of the ileum, immunohistochemistry trepanobiopsy.

Results.During the 4‑year examination in the patient’s blood, an M-gradient in the gamma zone was detected, monoclonal immunoglobulin М-κ 19.3 g / l, Bens-Jones-κ protein in urine (daily proteinuria 0.45 g) was detected during immunofixation. In the myelogram at the light-optical level, the number of cell elements was significantly reduced with a pronounced lymphoid proliferation of 40 %, the granulocytic series and erythropoiesis were relatively narrowed, and plasma cells 6 %. Immunomorphological picture trepanobiopsy our patient based on the data of laboratory methods of research corresponds to the defeat of the bone marrow in Waldenström’s disease-κ, secretion of M-paraprotein. An important feature that allowed to go on the right path of diagnosis was almost pathognomonic for tumor lymphoproliferation, detection of Bens-Jones protein in the urine, which was absent in the onset of the disease.

Conclusion.This clinical case is interesting not only by the complexity of the diagnosis of macroglobulinemia of Waldenström in General, but also by the atypical, erased clinical disease in our patient.
Grigory Antonovich Zakharyin, an outstanding Clinician of the 19th century (Celebrating the 190th anniversary of his birth)
Authors: Natalskaya N. Yu. , Chufistova N. N.
Published: August 2019

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Suspension of the License for Implementation of Medical, Pharmaceutical Activity in Administrative (Extrajudicial) Procedure
Authors: Roshchin D. O. , Plutnitskiy A. N. , Chimbireva A. A.
Published: August 2019

The article is devoted to the consideration of the problems of administrative suspension of the license for medical and pharmaceutical activity. The article highlights that the law-maker has provided for the possibility of suspension of the license in administrative order if the activity of the licensee is suspended in general, as well as if there is a failure to comply with the order to eliminate an essential breach of the license under consideration. At the same time, the lack of by-laws and explicit instructions in the law concerning operation of such provisions in respect of licensees engaged in medical and pharmaceutical activities does not prevent application of mechanisms in question. The authors note that a wider application of the license suspension would be facilitated by the adoption of normative legal acts regulating the procedure for the application of administrative measures in the health sector.
Legal Regulation of Budget Control in the Federal Cities of the Russian Federation (A Case Study of the City of Sevastopol)
Authors: Petruchak A. V.
Published: August 2019

The author considers budget control as the most important type of state financial control. The article analyzes approaches to understanding budget control, discusses the sources of legal regulation of budget control in the federal cities of the Russian Federation, types and methods of exercising budget control in federal cities (on the example of the city of Sevastopol). The author comes to the conclusion that normative legal acts of constituent entities f the Russian Federation — the federal cities of the RF — determine the issues of budgetary control in different ways. In some cases regional budget legislation in federal cities contradicts the federal laws, in connection with which it is necessary to bring normative legal acts of constituent entities of the Russian Federation into line with the federal legislation. However, the lack of a uniform normative legal act regulating the procedure for budgetary control at the federal level leads to gaps and inaccuracies in the mechanism of legal regulation of control-budgetary relations at the level of the constituent entities of the Russian Federation.
The Format of the Result of Intellectual Activity as an Emerging Object of Intellectual Rights
Authors: Ananieva A. Yu.
Published: August 2019

The article investigates the tendency of “formatization” of the results of intellectual activity that is also taking place in cross-border private law relations. On the basis of the analysis of foreign and Russian legal doctrines, jurisprudence and case law, the author comes to the conclusion about the independence of the format as a result of intellectual activity and about the possibility of using formats not only for audiovisual works, but also for some other categories of intellectual property regardless of protectability of the latter as objects of intellectual property rights. Taking into account the above, the author proposes a definition of the concept “format of the result of intellectual activity” that is generic in relation to the concept of “format of an audiovisual work”. The author substantiates the system of concepts included in the scope of the generic concept “format of the result of intellectual activity.” The conclusion is made that the concept of the format of the result of intellectual activity has a significant potential for development as an independent object of intellectual property.
Safety of Employees Activities Arrangement in Correctional Facility Departments and Services
Authors: Komarov S. V.
Published: August 2019

The paper is devoted to the consideration of the organizational and practical activities of the departments and services of correctional facilities in ensuring the employees safety. The problems and the main functions of the departments and services of correctional facilities in the direction of ensuring the safety of employees are analyzed. The author provides statistics on key performance indicators, reflecting up-to-date information on the state of security and crime in prisons. The measures aimed at improving the effectiveness of the departments and services of correctional facilities to ensure the safety of employees are proposed.
Grant Funding for Research and Development Characteristics through the Analysis of Law Enforcement Practice of the EU Court
Authors: Slepak V. Yu. , Pozhilova N. A.
Published: August 2019

Evaluation of the effectiveness of legal regulation is impossible without considering the existing law enforcement, especially court, practice. The EU Court is a landmark institution of the European Union in the field of interpretation of rules of law. Therefore, the presence of a certain number of precedents in its practice, some of which may be the cornerstones not only in this field, but also in others, is of serious scientific and practical interest.

The analysis of the facts of real court cases, as well as questions of the interpretation of rules of law, allow us to consider a whole stratum of seemingly completely non-obvious problems (including legal gaps) with a view to eliminating them.
Еhe Court of the EAEU Main Approaches to Administration of Justice
Authors: Khachatryan E. A.
Published: August 2019

The paper describes the main approaches used by the Court of the EAEU in the administration of justice. This paper examines the practice of the Court of the EAEU in conjunction with the practice of the EurAsEC Court to increase the representativeness and validity of the topic. The analysis of the practice of the Court of the EAEU and the EurAsEC Court makes it possible to conclude that the main approaches to the administration of the Eurasian justice are the independence of the EAEU system of justice, the compulsory nature of the Court’s interpretations and the filling of gaps through the establishment and further specification of the EEC competences, which are not specified in the EAEU Treaty. The paper also analyzes the question of the Court of the EAEU consideration of the interpretation and explanation competence as its exclusive authority as the last, or rather the highest, court.
A Note on Fuzzy Soft Ditopological Spaces
Authors: DİZMAN Tuğba Han
Published: August 2019

In this study, we define fuzzy soft ditopological spaces as the generalization of soft ditopological spaces defined by Simsekler et. al.  (2016).  Fuzzy soft ditopological space is a combination of fuzzy soft topological and fuzzy soft cotopological spaces which are defined by two independent structures fuzzy soft open and fuzzy soft closed sets. Also we give fuzzy soft -continuity in fuzzy soft topology , fuzzy soft -continuity in fuzzy soft cotopology and by using these two types of continuity we finally define the fuzzy soft continuity in a fuzzy soft ditopology.
GP-Fuzzy Soft Groups
Authors: AKIN Canan
Published: August 2019

In this paper, the definition of a new concept which
is called GP-fuzzy soft subgroup is introduced and some basic
properties of the families of GP-fuzzy soft subgroups are examined.
THE MEDIATING ROLE OF SUPPLIER NETWORK, THE MODERATING ROLE OF FLEXIBLE RESOURCES IN THE RELATIONSHIP BETWEEN LEAN MANUFACTURING PRACTICES AND THE ORGANIZATIONAL PERFORMANCE
Authors: Saengchai Sakapas , Jermsittiparsert Kittisak
Published: August 2019

Purpose: Given the internationalization of business today, it illustrates the importance of companies looking for overseas market opportunities for the capture of and sustainability of competitive advantage. Following the success of companies from newly developed nations such as the Far East Asian nations of the Republic of Korea and the Republic of China, Taiwan and South East Asian countries such as Singapore, emerging economies are shifting to external sector growth through export industries from the internal sector growth of import substitutes industries. Thus the current study is interested in exploring the nexus between supply chain integration, export marketing strategies and export performance of Indonesian manufacturing firms.

Methodology: Employing the survey-based methodology, the SEM-PLS technique is used to test the hypothesized relationships. So, the current study has used SEM-PLS as a statistical tool to answer the research questions raised in this study and research objectives envisaged in the current study.

Results: The findings of the study have provided support to the theoretical foundation and proposed hypothesis of the current study. Current study will be helpful for policymakers and practitioners in understanding the issues related to supply chain risk, supply chain integration and supply chain agility. In the author's knowledge this is among very few pioneering studies on this issue.
THE MEDIATING ROLE OF SUPPLY CHAIN MANAGEMENT PRACTICES IN THE RELATIONSHIP BETWEEN MANUFACTURING FLEXIBILITY AND MANUFACTURING PERFORMANCE
Authors: Chetthamrongchai Paitoon , Jermsittiparsert Kittisak
Published: August 2019

Purpose: The current study is interested in exploring the nexus between manufacturing flexibility supply chain practices and manufacturing performance of Indonesian manufacturing firms. Multidimensionality of manufacturing flexibility within the function of manufacturing is generally accepted by past researchers and its importance honoured.

Methodology: Employing the survey-based methodology, the SEM-PLS technique is used to test the hypothesized relationships. So, the current study has used SEM-PLS as a statistical tool to answer the research questions raised in this study and research objectives envisaged in the current study.

Results: The complexity of manufacturing flexibility has made this concept difficult to comprehend yet delimit. To date, agreement on how to practice this concept has not yet been resolved. The findings of the study have provided support to the theoretical foundation and proposed hypothesis of the current study. Current study will be helpful for policymakers and practitioners in understanding the issues related to supply chain risk, supply chain integration and supply chain agility. In the author's knowledge this is among very few pioneering studies on this issue.
Direito constitucional de recorrer e a judicialização da ineficiência empresarial
Authors: Falcão Joaquim , Hartmann Ivar
Published: August 2019

Resumo: A judicialização das questões consumeristas atinge o Supremo Tribunal Federal por via dos juizados especiais há vários anos. Recentemente uma empresa do ramo de telefonia, a Oi, destacou-se pelo volume desproporcional de processos que levou ao tribunal. Ao analisar o perfil da litigância de direito do consumidor da Oi no Supremo, identificamos que a empresa envia o dobro de processos do segundo colocado no ranking de maiores litigantes, apesar de ter taxa de sucesso menor do que 0,07%. No contexto da necessidade de adequada proteção dos direitos do consumidor, esse comportamento pode ser caracterizado como bullying processual e demanda novas atitudes por parte dos órgãos reguladores e do próprio Supremo.Palavras-chave: Direito do consumidor. Judicialização. Supremo Tribunal Federal. Abstract: The consumer rights lawsuits have reached the Brazilian Supreme Court through small claims courts for years. Recently, one phone company, Oi, stood out for the disproportional number of appeals it took to the court. We found that Oi brought double the number of appeals of the second most frequent appellant in consumer rights at the Supreme Court, even though Oi’s success rate is lower than 0,07%. In the context of appropriate consumer rights protection, this behavior can be characterized as lawsuit bullying and calls for a new attitude by the regulating agencies and the Supreme Court itself.Keywords: Consumer rights. Lawsuits. Brazilian Supreme Court.
The role of the university in terms of realisation of freedom of teaching and freedom of scientific research – polish case
Authors: Syryt Aleksandra
Published: August 2019

Abstract: The terms "university", "teaching" and "research" are closely related. The reason for the establishment of a community of learners and students were, on the one hand, the formation of man, and on the other the search for the truth about man, life, society and the world. In the face of technological development and access to information, including the development of legislation that allows the individual, without going through formal institutions, data acquisition, the question arises whether the university is needed, and if so, what is its role in realizing the right to education and freedom of scientific research. Implementation of freedom of scientific research and freedom of teaching in times of universal information access and modern technology can do without the university. However, this is university that can benefit from innovative research methods and teaching remains the most important forum for the exchange of ideas and the search for truth and knowledge transfer, vocational skills and social attitudes.Keywords: Right to education. Freedom of scientific research. Constitution. Cultural rights. Freedom of teaching. Resumo: Os termos "universidade", "ensino" e "pesquisa" estão intimamente relacionados. A razão para o estabelecimento de uma comunidade de alunos e estudantes foram, por um lado, a formação do homem, e por outro a busca da verdade sobre o homem, a vida, a sociedade e o mundo. Em face de desenvolvimento tecnológico e do acesso à informação, incluindo o desenvolvimento de uma legislação que permite que o indivíduo, sem passar por instituições formais, tenha acesso a dados e a informações, gera a questão de saber se a universidade é necessária, e em caso afirmativo, qual é o seu papel na realização dos direitos à educação e à liberdade de pesquisa científica. A implementação da liberdade de investigação científica e liberdade de ensino em tempos de acesso à informação universal e tecnologia avançada pode se realizar sem a universidade. No entanto, a universidade pode se beneficiar de métodos inovadores de pesquisa e de ensino e continuar a ser o mais importante fórum para a troca de ideias ea busca da verdade e da transferência de conhecimentos, competências profissionais e as atitudes sociais.Palavras-chave: Direito à Educação. Liberdade de Pesquisa Científica. Constituição. Direitos Culturais. Liberdade de Ensino.
FORMANDO O DOCENTE E FORMANDO EM TRABALHO: PROFISSIONAIS LIBERAIS E SUA CONSTRUÇÃO DE SABERES PEDAGÓGICOS
Authors: Clasen Julia Hélio Lino , Oliveira Lee Elvis Siqueira de
Published: August 2019

Com a finalidade de compreender como se constituem docentes os profissionais liberais no Ensino Técnico e as suas percepções na formação pedagógica no processo de tornar-se professor, buscamos investigar o motivo da escolha pela docência; identificar suas necessidades no cotidiano de sala de aula e sua compreensão sobre a formação pedagógica. O enfoque metodológico foi qualitativo e descritivo, e as técnicas de coleta de dados constituíram-se de entrevista semi-estruturada com oito docentes, além de análise documental. Este estudo se baseou principalmente na fundamentação teórica dos autores: Nóvoa (1992; 1999); Cunha (1989; 2002; 2010), Volpato (2010) e Tardif (2005). Os resultados apontaram como motivadores da escolha pela docência “o trabalho prévio com treinamento de pessoal”; “a oportunidade de trabalho” e; “a identificação com os conteúdos exigidos no concurso”.Palavras-chave: Profissional Liberal. Formação Docente. EnsinoTécnico.
LA NOCIÓN DE SUJETO EN EDUCACIÓN: APORTES PARA REPENSAR LA PRÁCTICA DOCENTE
Authors: Irigaray Stefanía Conde
Published: August 2019

Palabras clave: SUJETO - ENSEÑANZA - APRENDIZAJE – DESEO
FORMAÇÃO DOCENTE E PEDAGOGIA: VISÃO DE DISCENTES SOBRE O CURSO
Authors: Rolim Nozângela Maria , Castro Gislaine Müller de , Spagnolo Carla
Published: August 2019

Este estudo apresenta a visão de estudantes do curso de Pedagogia, do 4º ao 10º período, do Centro de Formação de Professores/CFP, da cidade de Cajazeiras/PB, Campus pertencente à Universidade Federal de Campina Grande/UFCG. O objetivo geral foi compreender a percepção dessas alunas, a partir da realidade de cada uma.  A pesquisa, de cunho qualitativo, levou em consideração o que elas pensam, sentem, ouvem, vêm, falam, fazem, suas dores e necessidades dentro e fora da universidade. Esse trabalho foi de extrema relevância, pois proporcionou momentos de escuta das estudantes, como pessoas que enfrentam várias dificuldades para estar na sala de aula, tais como: falta de apoio dos colegas devido o desprestígio econômico da docência. Apesar da satisfação demonstrada pelas alunas sobre o curso e a universidade que frequentam, bem como as perspectivas positivas quanto a profissão, sentem-se desvalorizadas mediante falas e opiniões de colegas e familiares.Palavras-chave: Estudantes; Educação Superior; Realidade; Perspectivas.
RELAÇÃO TEORIA E PRÁTICA NA FORMAÇÃO DOCENTE:SUBSÍDIOS DE INOVAÇÃO
Authors: Monteiro Francisca Ocilma Mendes
Published: August 2019

No processo de formação inicial docente a relação teoria e prática se impõe e desafia os professores formadores. Para compreendera dimensão teórica e prática em uma visão de unidade, este trabalho investigativo objetivou apresentar algumas reflexões, fundamentada em diferentes autores e em alguns marcos legais, sobre as mudanças ocorridas na formação inicial docente no que se refere a relação teoria e prática.Os principais teóricos que embasaram esse estudo foram: Cunha (1998,2013); Lucarelli (2009); Freire (1996); Sousa Santos (1987); Pimenta (2006) e outros. Nesta perspectiva, fez-se uma análise de estudos, já publicados, e na legislação educacional brasileira, priorizando as normativas a partir da Lei de Diretrizes e Bases da Educação Nacional (9.394/1996). Assim, a formação docente converge para uma proposta que rompe com a dicotomia presente nas dimensões teórica e prática se encaminhando para uma perspectiva de integração relacional e de inovação.Palavras-chave: Formação de Professores; Relação teoria-prática; Inovação.
A FORMAÇÃO CONTINUADA E ATUAÇÃO DO COORDENADOR PEDAGÓGICO FRENTE AOS DESAFIOS DA EVASÃO ESCOLAR
Authors: Maiolino Elielma Velasquez de Souza
Published: August 2019

A presente pesquisa teve como objetivo analisar a formação continuada e a atuação do Coordenador Pedagógico dentro do contexto das evasões escolares na rede pública de ensino do município de Corumbá/MS. Essa análise foi obtida à partir do trabalho de conclusão de curso, requerido pelo curso de pós-graduação latu sensu em Coordenação Pedagógica, ofertado pelo Ministério da Educação e realizado por coordenadores das escolas públicas de ensino. Autores como: Arroyo (1997), Johann (2012), Gadotti (1995) e outros contribuíram com no diálogo teórico dessa pesquisa. Refletir a formação continuada do coordenador dentro do espaço escolar, juntamente com os pares que desenvolvem o processo de ensino e aprendizagem, demonstra que ele é um forte aliado no desafio de superação da evasão escolar.Palavras-chave: Formação continuada; Coordenador Pedagógico; Evasão Escolar.
Professor de música: legislação e formação em questão
Authors: Nogueira Melissa Azevedo
Published: August 2019

O presente artigo tem em sua base fundamental uma revisão histórica que perpassa alguns marcos legais desde o século XIX até os dias atuais, com o que, se pretendeu contextualizar no tempo, o ensino de música na escola. A relevância está no questionamento da polivalência no ensino da Arte, qual seja o professor formado em música ter que lecionar outras linguagens para o qual não foi habilitado tendo como objetivos principais compreender como se deu o percurso do ensino de música na escola pelo viés da legislação educacional e entender o impacto dessas legislações na compreensão da construção e implementação do fazer docente no ensino de música. Para a condução do trabalho foi utilizado o método da revisão bibliográfica segundo o qual, estabelecidos o tema e objetivos propostos, procura-se por pesquisas produzidas ou fontes legais, que fundamentem o estudo que se pretende desenvolver. Nesse sentido, além de se fazer uma breve incursão pela legislação, também se fez uma busca de diversos artigos e dissertações de autores que abordam, no contexto do processo histórico de sistematização da educação no Brasil, a Educação Musical. A partir do resultado das leituras discute-se que, para se pensar em ensino musical temos que iniciar pensando em como a Educação começa. Assim, antes de chegarmos ao século XX, quando as pesquisas ficaram mais frequentes, considerou-se importante compreender como se deram as primeiras manifestações educativas no Brasil do ensino de música e consequentemente na formação do professor, desde a vinda dos jesuítas europeus quando o país ainda era colônia de Portugal até a formalização do ensino musical na escola pública do século XIX. Desde então, este ensino tem sido ofertado em condições diversas e, a partir da LDB nº 9.394 de 1996 até os dias atuais, porém, englobando junto aos conhecimentos musicais, os do teatro, da dança e das artes visuais. Conclui-se que a polivalência e a multiplicidade das práticas pedagógicas trouxeram confusão na construção de identidade das licenciaturas. É possível compreender os motivos que levaram a disciplina Arte, como é hoje, possuir em sua identidade diversas interpretações por toda a comunidade escolar que vai desde alunos, coordenadores, diretores, professores e administrativo. São costumeiras as experiências em que todos se reportam à disciplina Arte como “Artes” inclusive pelos próprios professores da cadeira. Sendo assim, a configuração atual, que está posta é: professores de Arte devem lecionar as quatro linguagens, mesmo tendo a formação em apenas uma delas, causando por vezes um sentimento de inadequação e descontentamento nos professores.Palavras-chave: Educação musical. Legislação Educacional Brasileira. Professores de música.
The use of Petri nets in the study of networked control systems
Authors: Yuness S. , Lobusov E.S.
Published: August 2019

The use of communication networks in control systems has several important advantages, such as the ability of information transfer and remote control of various objects, the possibility of modifications and maintenance. On the other hand, the time between reading measurements from the sensor and sending a control signal to the actuator depends on the network characteristics (topology and routing scheme), and such a time delay can greatly affect the overall network performance. Delays, distortions and loss of transmitted data not only degrade the performance of the network management system, but also destabilize it. The paper considers the use of Petri nets as a method for modeling networked control systems (NCS) on the example of designing an active suspension control system for a car. When modeling, the star and common bus topologies were used, the comparison of which revealed that control systems with the common bus topology function 40% faster than systems with the star topology.
Experimental study of the turbulent boundary layer in the presence of a rectangular perforated rib
Authors: Afanasiev V.N. , Kong Dehai , Getya S.I. , Trifonov V.L.
Published: August 2019

Separated flows are widespread in many areas of science and technology, such as space technology, aviation, gas turbines, etc., which has a significant effect on the processes of hydrodynamics and heat transfer in them. The separation of the flow and its reattachment can serve as a powerful means of enhancing heat and mass transfer processes, and its organization is quite simple and reliable in terms of technology. This paper presents the results of the experimental study on hydrodynamics and heat transfer in the separation zone in front and behind a single rectangular perforated rib located on a flat plate heated by the law of qw = const. Experimental measurements were carried out using the Pitot-Prandtl tube and Dantec Dynamics hot-wire anemometry system, which allows us to obtain new characteristics of the turbulent boundary layer, both mean and oscillatory ones. We analyzed the influence of the perforation ratio of the rib and the location of the holes in the rib on the heat transfer efficiency. It was established that the stagnant and recirculation zones in front and behind the perforated rib were shifted and became smaller or disappeared. Findings of research show that jet flows, impinging on the heat transfer surface from the perforation holes, provide more efficient heat transfer behind the perforated rib, compared to that behind the solid rib.
Aerodynamic characteristics of detachable fairing shells in a subsonic incompressible flow
Authors: Grebeneva Yu.V. , Lutsenko A.Yu. , Nazarova A.V.
Published: August 2019

The purpose of the work was to mathematically simulate the flow around the fairing shell of the launch vehicle at a low subsonic free-stream velocity in the α = 0...360° angle-of-attack range. The calculations were performed using the SolidWorks Flow Simulation software package and the open source OpenFoam package based on the use of numerical methods for simulating the motion of liquid and gas. Within the research, we obtained the flow patterns and the aerodynamic coefficients of the longitudinal and normal forces, the pitch moment, and calculated the aerodynamic quality of the shell. Furthermore, we determined the positions of the stable equilibrium of the model and revealed the features of the flowing around the shell of the combined form at flow from the convex and concave sides. Next, we analyzed the leeward lift-off zones and the zones with increased pressure on the windward surface during flow from the concave side. Finally, we compared the obtained characteristics with the experimental data of TsAGI.
Modeling the processes of aerogasdynamics of structural elements of a supersonic aircraft
Authors: Studennikov E.S.
Published: August 2019

The purpose of the research was to study the aerodynamic features of the flow around the simplest structural elements of an aircraft, such as sharp and blunt-nose cones. For calculations we applied the perfect gas model. To describe flows with large adverse pressure gradients, we used the Menter's shear stress transfer model. We analyzed changes in the aerodynamic characteristics of the cones in a wide range of angles of attack α and flow Mach M∞ numbers. Furthermore, we investigated the parameters of the base region of the sharp cone at transonic and supersonic speeds, and compared the simulation results with the data of a physical experiment both in wind tunnels and on a ballistic installation. The comparison showed good agreement with the experimental data. Numerical simulation data can be applied to form the external appearance of aircraft for various purposes, to study the influence of the temperature factor on the flow around bodies, and to create semi-empirical models for calculating the parameters of the base region of conical bodies.
Research and development of an air gun for dispersion of powder in surgery
Authors: Demikhov K.E. , Ochkov A.A. , Demyanenko V.I. , Sitnikov M.V.
Published: August 2019

The comparative analysis of modern devices for spraying of powder is carried out. The pneumatic spray of powder for use in the surgical sphere promoting healing of wounds with the increased regeneration of soft fabrics after surgical intervention with a possibility of regulation of feed rate of material is designed. The studied spray is considered as the system of pneumotransport of bulks, its main characteristics are calculated, the drawing is developed, the 3D model is constructed. The current of gas in the operating volume of the pneumatic spray is explored, the dependence of distribution of pressure is given in the operating volume of the considered device.
Biotechnological bases of the development of cloned pig embryos
Authors: Lopukhov A. V. , Singina G. N. , Zinovieva N. A.
Published: August 2019

The term ‘clone’ in animal biotechnology refers to an organism derived from non-sexual reproduction, which is both a direct offspring and a genetic copy of the parent organism. To date, the pig appears to be the most interesting object in cloning research. Somatic cell nuclear transfer in pigs has a wide range of potential applications in various fields of human scientific and economic activities. However, the efficiency of producing cloned embryos in swine is still lower than that of other livestock species, in particular horses and cattle. Somatic cell nuclear transfer is a technically complex multi-stage technology, at each stage of which the pig oocytes, which are more susceptible to changes of surrounding conditions, are affected by various factors (mechanical, physical, chemical). At the stage of oocyte maturation, changes in the cell ultrastructures of the ooplasm occur, which play an important role in the subsequent nuclear reprogramming of the transferred donor cell. Before transfer to the oocyte donor somatic cells are synchronized in the G0/G1 stage of the cell cycle to ensure the normal ploidy of the cloned embryo. When removing the nucleus of pig oocytes maturated in vitro, it is necessary to pay attention to the problem of preserving the viability of cells, which were devoid of their own nuclear material. To perform the reconstruction, a somatic cell is placed, using micro-tools, in the perivitelline space, where the first polar body was previously located, or in the cytoplasm of an enucleated oocyte. The method of manual cloning involves the removal of the oocyte nucleus with subsequent fusion with the donor cell without the use of micromanipulation techniques. The increased sensitivity of oocytes to the environmental conditions causes special requirements for the choice of the system for in vitro culture of cloned pig embryos. In this work, we have reviewed the modern methods used for the production of cloned embryos and identified the technological issues that prevent improving the efficiency of somatic cloning of pigs.
Prospects for marker-associated selection in tomato Solanum lycopersicum L.
Authors: Shcherban A. B.
Published: August 2019

The review gives a brief description of tomato, one of the main objects of olericulture for Siberia. The data on the main directions in the breeding of this culture, such as resistance to various pathogens, the nutritional properties of fruits, the timing of their maturation and storage are generalized. A separate chapter is devoted to the use of various types of DNA markers for constructing detailed genetic maps of the specified object, which, along with full-genome sequencing data, can be used to screen for genes responsible for breeding traits. Most of these traits, especially specific resistance to one or another pathogen, were transferred to the cultivated tomato by crossing with wild species, therefore, special attention was paid in the article to identifying and marking resistance genes to a variety of viral, fungal and bacterial pathogens occurring in Western Siberia and adjacent areas. Another important aspect for breeding is the nutrient content of tomato fruits, including carotenoids, vitamins, sugars, organic acids, etc. Recently, due to modern technologies of sequencing, SNP-genotyping, the development of new bioinformatic approaches, it has become possible to establish genetic cascades determining the biochemical composition of tomato fruits, to identify key genes that can be used in the future for marker-associated selection of nutritional value. And, finally, genetic works devoted to the problem of the optimal dates of fruit ripening in certain climatic conditions and their prolonged storage without loss of quality are discussed.
Characteristics of the gene pool of spring wheat (Triticum aestivum L.) for resistance to loose smut in the forest-steppe of Western Siberia
Authors: Orlova E. A. , Baechtold N. P.
Published: August 2019

Among the many diseases of spring wheat caused by pathogenic fungi, loose smut Ustilago tritici (Pers.) Jens. remains to be a dangerous disease with a wide range of distribution. In fields where there is no control over the emergence and spread of the disease, the yield reduction can be up to 10 %, and in the case of highly susceptible varieties, up to 40–50 %. Taking into account the increasing cost of seed protectants and their environmental damage, the cultivation of varieties resistant to loose smut is still the most affordable way to protect plants, reducing the pesticide load on agrocenoses. The crucial point in breeding for resistance is the use of resistant varieties as parental forms. The aim of our research was to isolate samples of spring wheat that are immune to loose smut against the background of artificial infection of plants with a population specific to the West Siberian region. The article presents the results of long-lasting studies of 350 genotypes of spring wheat of different ecological and geographical origin for resistance to disease. Physiological specialization of races was carried out on the basis of a differentiating set consisting of six varieties of soft wheat and three varieties of durum spring wheat. The obtained results in combination with literature data reveal changes in the racial composition of the pathogen population over the past 30–35 years. Varieties of foreign and domestic selection resistant to the West Siberian population of loose smut have been identified. Based on the analysis of pedigree samples, highly and practically resistant to loose smut, we concluded that in breeding for immunity to U. tritici, the same sources of resistance genes are most often used. Among the gene pool of spring wheat of foreign selection, the largest number of genotypes resistant to loose smut is assigned to the countries of the North American geographical zone (USA, Canada, Mexico). These are largely samples containing Ut1 genes, genes from spring wheat ‘Thatcher’ and its sister line ‘DC II-21-44’. Resistance genes in Russian wheat varieties can be traced from cultivars Beloturka, Poltavka, Selivanovsky Hare (using Saratovskaya 29 and its derivatives), and genes from wheatgrass lines AGIS 1 and Grecum 114.
Association of polymorphism TP53 Arg72Pro with radon-induced lung cancer in the Kazakh population
Authors: Bulgakova O. , Kussainova A. , Kakabayev A. , Kausbekova А. , Bersimbaev R.
Published: August 2019

Lung cancer is a problem of great concern and one of the commonest cancer diseases worldwide and in the Republic of Kazakhstan in particular. Radon exposure is classified as the second most important cause of lung cancer. According to the experts, the contribution of natural sources to the average annual radiation dose of the Kazakh population currently stands at 80 %, including 50 % from radon. However, the effect of radon on human health in the Republic of Kazakhstan is almost unknown. The tumor suppressor gene TP53 is a key mediator of the DNA damage response cascade following cell exposure to ionizing radiation. The common polymorphism TP53 Arg72Pro (rs1042522) is a risk factor for lung cancer in the Asian population, but until now no genetic association studies have been done in the Kazakh population. No information on the synergistic carcinogenic effect of radon exposure and polymorphism TP53 Arg72Pro (rs1042522) is available either. This paper presents the results of the study of association between alteration in the TP53 gene and radon-induced lung cancer risk in the Kazakh population. Genetic association was assessed in a case-control study including 44 radon-exposed patients with lung cancer, 41 patients with lung cancer without radon exposure and 42 age/sex-matched healthy controls. We found that polymorphism TP53 Arg72Pro (rs1042522) was associated with lung cancer risk in the Kazakh population (OR = 6.95, 95 % CI = 2.41–20.05). Individuals with the Arg72Pro genotype also showed a significantly higher risk of radon-induced lung cancer (OR = 8.6, 95 % CI = 2.6–28.59).
Prediction of some peroxidase functions in Arabidopsis thaliana L. by bioinformatic search
Authors: Tugbaeva A. S. , Ermoshin A. A. , Kiseleva I. S.
Published: August 2019

Peroxidases of class III are common in various organisms. They are involved in lignin biosynthesis and plant protection against stressors. Peroxidases are presented in many isoforms, whose role is not always clear. The aim of this study is to analyze the amino acid sequences of reference peroxidases with known functions and peroxidases from Arabidopsis thaliana L. whose functions are unknown and to consider their putative roles in lignin biosynthesis. The structural and functional organization of peroxidases was analyzed by bioinformatical methods applied to open Internet sources. Seven reference peroxidases were chosen from four plant species: Zinnia sp., Armoracia rusticana P.G. Gaertn., Lycopersicon esculentum L. и Populus alba L. Twenty-four amino acid sequences of homologous peroxidases from A. thaliana were selected for the analyses with the BLAST service. Their molecular weights and isoelectric points were calculated. Multiple alignments of amino acid sequences and phylogenetic analysis were done. Sites of binding to monolignol substrates were identified in seven peroxidases from A. thaliana, and the enzymes were assigned to the groups of Sor G-peroxidases. Amino acid replacements in the primary structures of peroxidases were analyzed. Peroxidases from A. thaliana were clustered with reference peroxidases. They formed six clusters on the phylogenetic tree, three of which contained only A. thaliana peroxidases. Peroxidases within each cluster had similar molecular weights and isoelectric points, common localization of expression, and similar functions. Thus, the use of bioinformatics, databases, and published data bring us to assumptions as to the functions of several A. thaliana class III peroxidases. AtPrx39 peroxidase was shown to be affine to sinapyl alcohol; AtPrx54, to p-coumaryl and coniferyl alcohols. They are likely to participate in lignin biosynthesis.
The Temporal Stability of Buyers’ Preferences for Property Localization on the Housing Market in Szczecin
Authors: Batóg Barbara , Foryś Iwona
Published: August 2019

The housing market investors’ decisions are caused by their subjective expectations. These decisions are to do with financial resources, activity of local developers and buyers’ individual needs connected to the size of their household or their specific habits, as well as a sense of security and prestige of the neighborhood. The localization of a property is one of the most significant determinants of its price because of its spatial constancy. The attributes of a given residential area influence the value of properties and this phenomenon can be observed through intensity of transactions and transaction prices. On the other hand, the neighborhood’s influence changes over time. These changes are sometimes slow but could be very substantial. That is why buyers’ preferences can also change over time. The aim of this research is the analysis of the temporal stability of buyers’ localization preferences on the housing market in Szczecin. The fixed effects model, which allows for the comparison of changes in apartments’ prices in residential areas, has been applied. The data came from notarial deeds, from registers of real estate prices and values concerning transactions on the housing market in Szczecin.
Czy nowotwory złośliwe przyczyniły się do nadumieralności mężczyzn w wieku 65 lat i więcej w województwie łódzkim w latach 1999–2014?
Authors: Ciabiada-Bryła Beata , Drygas Wojciech , Pikala Małgorzata , Bryła Marek , Maniecka-Bryła Irena
Published: August 2019

Celem artykułu jest analiza umieralności z powodu chorób nowotworowych mężczyzn i kobiet w wieku 65+ w województwie łódzkim w latach 1999-2014, ze szczególnym uwzględnieniem zjawiska nadumieralności mężczyzn. Analizą objęto informacje o 501 124 zgonach odnotowanych w województwie łódzkim w latach 1999-2014. Obliczono rzeczywiste i standaryzowane współczynniki umieralności szczegółowej według przyczyn zgonów na podstawie ICD–10 oraz wskaźniki nadumieralności. Analizę trendów czasowych przeprowadzono za pomocą modeli joinpoint. W badanym okresie zaobserwowano nieznaczne obniżenie standaryzowanych współczynników umieralności (na 10 000 ludności) z powodu nowotworów złośliwych wśród osób w wieku 65+: w grupie mężczyzn z 171,7 do 166,8, a w grupie kobiet z 83,9 do 81,7. Wskaźnik nadumieralności na początku i na końcu ba danego okresu wynosił 2,0. W klasie C00‑C97 najważniejszymi przyczynami zgonów wśród mężczyzn w wieku 65+ w 2014 roku były nowotwory złośliwe (wskaźnik na 10 000 ludności): tchawicy, oskrzela i płuca (46,0); jelita grubego, odbytnicy i odbytu (19,0); gruczołu krokowego (18,4). Natomiast wśród kobiet powyżej 65 roku życia były to nowotwory: tchawicy, oskrzela i płuca (12,6); jelita grubego, odbytnicy i odbytu (11,3); piersi (8,8). Zjawisko nadumieralności mężczyzn w wieku 65 lat i więcej z powodu chorób nowotworowych w województwie łódzkim w 2014 roku było determinowane w największym stopniu nowotworami złośliwymi: pęcherza moczowego, tchawicy, oskrzela i płuca oraz żołądka.
Survival Modelling of Repeated Events Using the Example of Changes in the Place of Employment
Authors: Grzenda Wioletta
Published: August 2019

This paper concerns the issue of survival modelling in the case of repeated events. In the modelling of this type of events, attention should be paid to the existence of dependence among the analysed durations, as well as the occurrence of unobserved heterogeneity. One of the ways to include these aspects in the analysis is to use models with random effects. The primary objective of this paper is to present the application of such models to analyse changes in the place of employment. The duration of individual periods of employment for the surveyed employees was modelled. The approach used made it possible to identify factors influencing decisions on job changes, but also to assess the risk of occurrence of events such as termination of employment, and to examine the impact of unobserved heterogeneity on the results of the estimations.
О нестручном напредовању и стручном назадовању
Authors: Војновић Жарко
Published: August 2019

Рад се бави анализом неколико начелних питања у вези са стицањем стручних звања у библиотечко-информационој делатности, кључних за схватање смисла стручног напредовања. Правилник о ближим условима за стицање виших стручних звања у библиотечко-информационој делатности и бодовна листа који регулишу стицање стручних звања извор су многих неспоразума и отворених злоупотреба. Њихова примена у пракси показала је да се углавном настоји на испуњавању формалних услова код кандидата. Принципијелна питања, попут тачнијег одређивања опсега библиотечко- информационе делатности, процене квалитета, (не)оправданости начина вредновања редовних послова, као и праведности валоризације, доследно се избегавају. Све је то довело до хиперпродукције кандидатура, снижавања нивоа струке, због чега је замагљен и сам смисао стручног напредовања.