bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Media and Attitude Change: Information Booming Promote or Resist Persuasion?
Authors: Wang Yizhi , Dai Yuwan , Li Hao , Song Lili
Published: June 2021

Emerging social media platforms such as Twitter and its Chinese equivalent Weibo have become important in information-sharing and communication. They are also gradually becoming stronger in guiding public opinion. When compared with traditional media, these platforms have salient characteristics, such as highly efficient dissemination of information and interactive commentary, which can contribute to information overload. In earlier research, only the effect of social media on attitude change has been studied, but the specific mechanism of this effect in the context of information overload has not been found. To answer this question, we measured the attitude change of participants after they read Weibo posts about street vendors. A 2 (post-attitude: positive posts vs. negative posts) × 4 (reading time: 35 vs. 25 vs. 15 vs. 5 min) experiment was set up, and the Single Category Implicit Attitude Test was used to measure the implicit attitudes. The interaction effect revealed that in both positive and negative posts, less reading time (i.e., information overload) had a stronger influence. Users were more easily persuaded by posts under high overload. Furthermore, the changes in the attitudes of users were not simply stronger with more information. We found three stages, namely, obedience, resistance, and acceptance, with different mechanisms. Therefore, in the positive information overload condition, the attitudes of individuals eventually change in a positive way. In the negative information overload condition, individuals tend to be biased against the group being reported.
How Do Reference Points Influence the Representation of the N200 for Consumer Preference?
Authors: Wang Guangrong , Li Jianbiao , Zhu Chengkang , Wang Shenru , Jiang Shenzhou
Published: June 2021

Recent studies have suggested that event-related brain potential (ERP) can represent consumer preference, and there is consensus that the N200 is the best indicator of consumer preference. Measurement of reference-dependent consumer preference, in turn, requires a reference point, but it remains largely unknown how reference points modulate the preference-related N200. We designed an experiment to investigate how reference points affect the N200 based on classical paradigms. In the single-reference condition, one product was displayed in each trial; in the conjoined-reference condition, a pair of products was displayed simultaneously. Our results showed that in the single-reference condition, low-preference products elicited more negative N200 than high-preference products, replicating previous results, but the N200 could not distinguish between low‐ and high-preference products when viewing two options of similar subjective value in the conjoined-reference condition. These findings suggest that reference points modulate the representation of the N200 on consumer preference. When only viewing one product, participants make a value judgment based on their expectations. However, when viewing two products simultaneously, both their expectation and the alternative product can serve as reference points, and whether the N200 can represent consumer preference depends on which reference point is dominant. In future research, reference points must be controlled when the N200 is used to explore value-related decision-making.
Psychological Predictors of Energy Saving Behavior: A Meta-Analytic Approach
Authors: Carrus Giuseppe , Tiberio Lorenza , Mastandrea Stefano , Chokrai Parissa , Fritsche Immo , Klöckner Christian A. , Masson Torsten , Vesely Stepan , Panno Angelo
Published: June 2021

Understanding how psychological processes drive human energy choices is an urgent, and yet relatively under-investigated, need for contemporary society. A knowledge gap still persists on the links between psychological factors identified in earlier studies and people's behaviors in the energy domain. This research applies a meta-analytical procedure to assess the strength of the associations between five different classes of individual variables (i.e.,: attitudes, intentions, values, awareness, and emotions) and energy-saving behavioral intentions and behaviors (self-reported and actual). Based on a systematic review of studies published between 2007 and 2017, we estimate the average effect size of predictor-criterion relations, and we assess relevant moderators and publication bias, drawing on data obtained from 102 independent samples reported in 67 published studies (N= 59.948). Results from a series of five single meta-analyses reveal a pattern of significant positive associations between the selected psychological determinants and energy-saving indicators: associations between individual-level predictors and energy-saving outcomes are positive and moderate in size, ranging from large effects for emotions to small-moderate effects for pro-environmental values. Interestingly, moderation analysis reveals, among other things, that attitude-behavior links are not statistically significant when actual behavior is considered as an outcome. Implications for policy interventions are discussed.
Performance Pressure as an Antecedent and Authentic Leadership as a Moderator of the Relationship Between Co-worker Undermining and Psychological Capital
Authors: Jang Eunmi , Kim Hyunkoo
Published: June 2021

As a component of organizational aggression, co-worker undermining erodes the well-being of the victims and the sustainability of the organization. Drawing on conservation of resources theory, this study identified the negative impact of co-worker undermining on the victim’s psychological capital, and empirically examined the influence of performance pressure as an antecedent and of authentic leadership as a moderator to suggest approaches to minimize this negative impact. A total of 485 subordinate employees from 10 organizations in South Korea completed a questionnaire survey. To prevent common method bias, the survey was designed to recruit participants from multiple organizations and was conducted in two waves. First, the results revealed that performance pressure had a positive relationship with the perception of co-worker’s undermining. Second, this perception of co-worker undermining had a negative influence on the victim’s psychological capital. Third, authentic leadership had the moderating effect of decreasing the negative relationship between co-worker undermining and psychological capital. Furthermore, authentic leadership moderated the mediating relationship between the performance pressure and psychological capital through co-worker’s undermining. These findings suggest that the level of performance pressure should be managed in advance so as not to reach excessive levels and the psychological capital of victims should be preserved through authentic leadership to minimize the negative impact of co-worker undermining.
Examining the Relationship Between Grit and Foreign Language Performance: Enjoyment and Anxiety as Mediators
Authors: Liu Eerdemutu , Wang Junju
Published: June 2021

The relationship between grit and success has been investigated extensively in various contexts. However, the association between grit and language performance, especially in a Chinese high school context, remains underexplored. This study investigates grit, the positive emotion of enjoyment, the negative emotion of anxiety, foreign language performance, and how enjoyment and anxiety mediate the relationship between grit and foreign language performance. A questionnaire was administered to 697 Chinese high school students, followed by a language test after 2 weeks. The results showed that more than half of the students had a moderate-high level of grit and foreign language enjoyment and that nearly half of them experienced a low-moderate level of foreign language anxiety. It was also found that grit, foreign language enjoyment, and foreign language performance were positively correlated with each other, and all three variables were negatively correlated with anxiety. Both foreign language enjoyment and foreign language anxiety mediated the relationship between grit and foreign language performance to a significant degree, and the mediating effect of foreign language anxiety was stronger than that of foreign language enjoyment.
Social and Cognitive Interactions Through an Interactive School Service for RTT Patients at the COVID-19 Time
Authors: Dovigo Lucia , Caprì Tindara , Iannizzotto Giancarlo , Nucita Andrea , Semino Martina , Giannatiempo Samantha , Zocca Lia , Fabio Rosa Angela
Published: June 2021

Background: The closure of all educational institutions and most rehabilitation centres represents a precautionary measure to face the COVID-19 pandemic, but the isolation and social distancing may be particularly challenging for children with special needs and disabilities (SEND), such as Rett Syndrome (RTT). The main aim of this study was to promote cognitive and social interactions among children with RTT through an interactive school program.

Methods: The Interactive School palimpsest was composed of moments in which a teacher spoke directly to children with RTT and expected a response through eye gaze, and moments in which storeys-cartoon were presented while tracking the eye gaze of children. We investigated behavioural, social and cognitive parameters.

Results: Children participated in both social and cognitive tasks with the spontaneous reduction of stereotypies and with increase in attention. They recalled more significant indexes when music or a song was presented together with a cartoon or a cognitive task.

Conclusions: This study provides initial insights in promoting cognitive and social interactions and in the support needs of families with a child with RTT during the COVID-19 pandemic.
Autistic Traits Predict Social-Contact Uncertainty in University Students
Authors: Bertrams Alex , Zäch Myriam
Published: June 2021

Social anxiety (alternatively: social-contact uncertainty) in the university context can lead to reduced health, well-being, and performance, and can even cause premature leaving of education. With the present study, we intended to supplement cross-sectional studies on students' autistic traits and social anxiety with longitudinal findings. We measured autistic traits and social-contact uncertainty of 118 university students on two occasions, roughly 1 year apart. Correlation, multiple regression, and cross-lagged analyses showed that more pronounced autistic traits predicted higher future social-contact uncertainty. Social-contact uncertainty did not predict autistic traits. We conclude that university students who are high in autistic traits tend not only to be more socially anxious at the moment but have a heightened risk of still being so in the future.
An Examination of the Feasibility of Detecting Cocaine Use Using Smartwatches
Authors: Ertin Emre , Sugavanam Nithin , Holtyn August F. , Preston Kenzie L. , Bertz Jeremiah W. , Marsch Lisa A. , McLeman Bethany , Shmueli-Blumberg Dikla , Collins Julia , King Jacqueline S. , McCormack Jennifer , Ghitza Udi E.
Published: June 2021

As digital technology increasingly informs clinical trials, novel ways to collect study data in the natural field setting have the potential to enhance the richness of research data. Cocaine use in clinical trials is usually collected via self-report and/or urine drug screen results, both of which have limitations. This article examines the feasibility of developing a wrist-worn device that can detect sufficient physiological data (i.e., heart rate and heart rate variability) to detect cocaine use. This study aimed to develop a wrist-worn device that can be used in the natural field setting among people who use cocaine to collect reliable data (determined by data yield, device wearability, and data quality) that is less obtrusive than chest-based devices used in prior research. The study also aimed to further develop a cocaine use detection algorithm used in previous research with an electrocardiogram on a chestband by adapting it to a photoplethysmography sensor on the wrist-worn device which is more prone to motion artifacts. Results indicate that wrist-based heart rate data collection is feasible and can provide higher data yield than chest-based sensors, as wrist-based devices were also more comfortable and affected participants' daily lives less often than chest-based sensors. When properly worn, wrist-based sensors produced similar quality of heart rate and heart rate variability features to chest-based sensors and matched their performance in automated detection of cocaine use events.

Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT02915341.
Socio-Demographics Correlate of COVID-19 Vaccine Hesitancy During the Second Wave of COVID-19 Pandemic: A Cross-Sectional Web-Based Survey in Saudi Arabia
Authors: AL-Mohaithef Mohammed , Padhi Bijaya Kumar , Ennaceur Soukaina
Published: June 2021

Background: The Coronavirus disease 2019 (COVID-19) pandemic is considered a major global public health threat affecting across the life course and socioeconomic aspects of life. Global acceptance to an effective vaccine is the most anticipated resolution. This study aims to evaluate intent to be vaccinated among public in Saudi Arabia during the second wave of the COVID-19 pandemic.

Methods: A cross-sectional web-based study was designed in Saudi Arabia. Study participants (N = 658) were recruited through snowball sampling. The SurveyMonkey platform was used to record the response. Cross-tabulation was performed by participants' intention to vaccinate against COVID-19 virus with sociodemographic characteristics and respondents' risk perception toward COVID-19, trust in the healthcare system, and their history of vaccine hesitancy behavior. Multivariable logistic regression analysis was performed to compute the predictors of vaccination intention among the study participants.

Results: Six hundred fifty-eight participants completed the survey (females = 47.4%). Of the 658 participants, 351 (53.3%) have shown intent to be vaccinated. Five hundred nineteen (78.8%) of the participants were reported to be at high risk of COVID-19, and 307 (46.6%) were reported to trust the healthcare system in the country. The multivariable analysis shows respondents with a high-risk perception (OR: 2.27, 95% CI: 1.49–3.48); higher trust in the healthcare system (OR: 3.24, 95% CI: 2.32–4.61) was found to be the significant factor affecting the decision in acceptance of the COVID-19 vaccine in Saudi Arabia.

Conclusion: Participants reported high knowledge toward COVID-19 virus, and vaccine developments. About half (46.6%) of the study participants reported refusal/hesitancy toward the vaccine during the second wave of the pandemic in Saudi Arabia. The study highlighted that higher risk perception and higher trust in the healthcare system were found to be the main reasons for participants' intentions behind the vaccination.
Toll-Like Receptors Represent an Important Link for Sex Differences in Cardiovascular Aging and Diseases
Authors: Echem Cinthya , Akamine Eliana H.
Published: June 2021

Human life span expectancy has increased, and aging affects the organism in several ways, leading, for example, to an increased risk of cardiovascular diseases. Age-adjusted prevalence of the cardiovascular diseases is higher in males than females. Aging also affects the gonadal sex hormones and the sex differences observed in cardiovascular diseases may be therefore impacted. Hormonal changes associated with aging may also affect the immune system and the immune response is sexually different. The immune system plays a role in the pathogenesis of cardiovascular diseases. In this context, toll-like receptors (TLRs) are a family of pattern recognition receptors of the immune system whose activation induces the synthesis of pro-inflammatory molecules. They are expressed throughout the cardiovascular system and their activation has been widely described in cardiovascular diseases. Some recent evidence demonstrates that there are sex differences associated with TLR responses and that these receptors may be affected by sex hormones and their receptors, suggesting that TLRs may contribute to the sex differences observed in cardiovascular diseases. Recent evidence also shows that sex differences of TLRs in cardiovascular system persists with aging, which may represent a new paradigm about the mechanisms that contribute to the sex differences in cardiovascular aging. Therefore, in this mini review we describe the latest findings regarding the sex differences of TLRs and associated signaling in cardiovascular diseases during aging.
Telerobotic Operation of Intensive Care Unit Ventilators
Authors: Vagvolgyi Balazs P. , Khrenov Mikhail , Cope Jonathan , Deguet Anton , Kazanzides Peter , Manzoor Sajid , Taylor Russell H. , Krieger Axel
Published: June 2021

Since the first reports of a novel coronavirus (SARS-CoV-2) in December 2019, over 33 million people have been infected worldwide and approximately 1 million people worldwide have died from the disease caused by this virus, COVID-19. In the United States alone, there have been approximately 7 million cases and over 200,000 deaths. This outbreak has placed an enormous strain on healthcare systems and workers. Severe cases require hospital care, and 8.5% of patients require mechanical ventilation in an intensive care unit (ICU). One major challenge is the necessity for clinical care personnel to don and doff cumbersome personal protective equipment (PPE) in order to enter an ICU unit to make simple adjustments to ventilator settings. Although future ventilators and other ICU equipment may be controllable remotely through computer networks, the enormous installed base of existing ventilators do not have this capability. This paper reports the development of a simple, low cost telerobotic system that permits adjustment of ventilator settings from outside the ICU. The system consists of a small Cartesian robot capable of operating a ventilator touch screen with camera vision control via a wirelessly connected tablet master device located outside the room. Engineering system tests demonstrated that the open-loop mechanical repeatability of the device was 7.5 mm, and that the average positioning error of the robotic finger under visual servoing control was 5.94 mm. Successful usability tests in a simulated ICU environment were carried out and are reported. In addition to enabling a significant reduction in PPE consumption, the prototype system has been shown in a preliminary evaluation to significantly reduce the total time required for a respiratory therapist to perform typical setting adjustments on a commercial ventilator, including donning and doffing PPE, from 271 to 109 s.
Threshold of Toxicological Concern—An Update for Non-Genotoxic Carcinogens
Authors: Batke Monika , Afrapoli Fatemeh Moradi , Kellner Rupert , Rathman James F. , Yang Chihae , Cronin Mark T. D. , Escher Sylvia E.
Published: June 2021

The Threshold of Toxicological Concern (TTC) concept can be applied to organic compounds with the known chemical structure to derive a threshold for exposure, below which a toxic effect on human health by the compound is not expected. The TTC concept distinguishes between carcinogens that may act as genotoxic and non-genotoxic compounds. A positive prediction of a genotoxic mode of action, either by structural alerts or experimental data, leads to the application of the threshold value for genotoxic compounds. Non-genotoxic substances are assigned to the TTC value of their respective Cramer class, even though it is recognized that they could test positive in a rodent cancer bioassay. This study investigated the applicability of the Cramer classes specifically to provide adequate protection for non-genotoxic carcinogens. For this purpose, benchmark dose levels based on tumor incidence were compared with no observed effect levels (NOELs) derived from non-, pre- or neoplastic lesions. One key aspect was the categorization of compounds as non-genotoxic carcinogens. The recently finished CEFIC LRI project B18 classified the carcinogens of the Carcinogenicity Potency DataBase (CPDB) as either non-genotoxic or genotoxic compounds based on experimental or in silico data. A detailed consistency check resulted in a dataset of 137 non-genotoxic organic compounds. For these 137 compounds, NOEL values were derived from high quality animal studies with oral exposure and chronic duration using well-known repositories, such as RepDose, ToxRef, and COSMOS DB. Further, an effective tumor dose (ETD10) was calculated and compared with the lower confidence limit on benchmark dose levels (BMDL10) derived by model averaging. Comparative analysis of NOEL/EDT10/BMDL10 values showed that potentially bioaccumulative compounds in humans, as well as steroids, which both belong to the exclusion categories, occur predominantly in the region of the fifth percentiles of the distributions. Excluding these 25 compounds resulted in significantly higher but comparable fifth percentile chronic NOEL and BMDL10 values, while the fifth percentile EDT10 value was slightly higher but not statistically significant. The comparison of the obtained distributions of NOELs with the existing Cramer classes and their derived TTC values supports the application of Cramer class thresholds to all non-genotoxic compounds, such as non-genotoxic carcinogens.
Reindeer Anthrax in the Russian Arctic, 2016: Climatic Determinants of the Outbreak and Vaccination Effectiveness
Authors: Liskova Elena A. , Egorova Irina Y. , Selyaninov Yuri O. , Razheva Irina V. , Gladkova Nadezhda A. , Toropova Nadezhda N. , Zakharova Olga I. , Burova Olga A. , Surkova Galina V. , Malkhazova Svetlana M. , Korennoy Fedor I. , Iashin Ivan V. , Blokhin Andrei A.
Published: June 2021

The Yamal Peninsula in the Russian Federation experienced a massive outbreak of anthrax in reindeer (Rangifer tarandus) in July–August 2016, with 2,650 (6.46% of the total susceptible population) animals infected, of which 2,350 died (case fatality rate of 88.67%). In our study, we analyzed climatic and epidemiological factors that could have triggered the outbreak. The cancelation of reindeer vaccination against anthrax in 2007 resulted in an increase in population susceptibility. In response to the outbreak, total vaccination of all susceptible animals was resumed. To assess the vaccination effectiveness, we tested 913 samples of blood serum taken from vaccinated reindeer using an antigenic erythrocyte diagnostic kit to detect specific anti-anthrax antibodies via an indirect hemagglutination assay (IHA) 9 months after vaccination. We found that 814 samples had sufficiently high levels of anti-anthrax antibodies to indicate a protection level of 89% (95% confidence interval: 87–91%) of the whole reindeer population. Abnormally high ambient temperature in the summer of 2016 contributed to the thawing of permafrost and viable Bacillus anthracis spores could have become exposed to the surface; the monthly average air temperatures in June, July, and August 2016 were 20–100% higher than those of the previous 30-year period, while the maximum air temperatures were 16–75% higher. Using the projected climate data for 2081–2100 according to the “worst case” RCP8.5 scenario, we demonstrated that the yearly air temperature may average above 0°C across the entire Yamal Peninsula, while the yearly number of days with a mean temperature above 0°C may rise by 49 ± 6 days, which would provide conditions for reactivation of soil anthrax reservoirs. Our results showed that the outbreak of anthrax occurred under conditions of a significant increase in air temperature in the study area, underlined the importance of vaccination for controlling the epidemic process, and demonstrated the effectiveness of monitoring studies using the IHA diagnostic kit for detecting erythrocyte anthrax antigens.
Propulsion Sizing Correlations for Electrical and Fuel Powered Unmanned Aerial Vehicles
Authors: Alulema Victor , Valencia Esteban , Cando Edgar , Hidalgo Victor , Rodriguez Dario
Published: June 2021

Despite the increasing demand of Unmanned Aerial Vehicles (UAVs) for a wide range of civil applications, there are few methodologies for their initial sizing. Nowadays, classical methods, mainly developed for transport aircraft, have been adapted to UAVs. However, these tools are not always suitable because they do not fully adapt to the plethora of geometrical and propulsive configurations that the UAV sector represents. Therefore, this work provides series of correlations based on off-the-shelf components for the preliminary sizing of propulsion systems for UAVs. This study encompassed electric and fuel-powered propulsion systems, considering that they are the most used in the UAV industry and are the basis of novel architectures such as hybrid propulsion. For these systems, weight correlations were derived, and, depending on data availability, correlations regarding their geometry and energy consumption are also provided. Furthermore, a flowchart for the implementation of the correlations in the UAV design procedure and two practical examples are provided to highlight their usability. To summarize, the main contribution of this work is to provide parametric tools to size rapidly the propulsion system components, which can be embedded in a UAV design and optimization framework. This research complements other correlation studies for UAVs, where the initial sizing of the vehicle is discussed. The present correlations suit multiple UAV categories ranging from micro to Medium-Altitude-Long-Endurance (MALE) UAVs.
Effect of Trichoderma spp. and Fertilization on the Flowering of Begonia × tuberhybrida Voss. ‘Picotee Sunburst’
Authors: Andrzejak Roman , Janowska Beata , Reńska Beata , Kosiada Tomasz
Published: June 2021

The aim of the study was to assess the influence of Trichoderma spp. and different fertilization levels on the flowering and nutritional status of Begonia × tuberhybrida Voss. ‘Picotee Sunburst’ plants. Before planting, the tubers were soaked in water or a mixture of spore of Trichoderma spp. (T. viride Schumach–Tv14, T. harzianum Rifai–Thr2, T. hamatum/Bonord/Bainier–Th15) in the form of a suspension for 24 h. The plants were fertilized every 7 days with the multi-component Peters Professional Allrounder fertilizer (20:20:20 + microelements) at a concentration of 0.0%, 0.2%, and 0.3%. Trichoderma spp. accelerated the flowering of the ‘Picotee Sunburst’ cultivar by 2.7–8.7 days, stimulated the development of buds and flowers in the plants and affected their size. The plants bloomed most intensively and had the biggest flowers after the treatment with the 0.3% fertilizer. Trichoderma spp. and the fertilization had no effect on the height of the plants and the number of shoots regardless of the fertilizer concentration, but they stimulated the development of leaves. Trichoderma spp. stimulated the production of chlorophyll. They did not affect the uptake of macroelements, but they stimulated the uptake of microelements (Zn, Fe, and B). The higher the fertilizer concentration was, the higher was the content of microelements in the plants.
Helichrysum italicum (Roth) G. Don Essential Oil from Serbia: Chemical Composition, Classification and Biological Activity—May It Be a Suitable New Crop for Serbia?
Authors: Aćimović Milica , Ljujić Jovana , Vulić Jelena , Zheljazkov Valtcho D. , Pezo Lato , Varga Ana , Tumbas Šaponjac Vesna
Published: June 2021

H. italicum essential oil (EO) is one of the most popular ingredients utilized by the cosmetic industry, and it is also used as natural antioxidant and as a value-added ingredient in food products. The chemical composition of the EO H. italicum cultivated in Serbia was analyzed by gas chromatography–mass spectrometry. The quantitative structure–retention relationship was used to predict the retention indices of the EO constituents acquired by GC-MS data, applying five molecular descriptors selected by factor analysis and a genetic algorithm. Also, antimicrobial activity, and biological activity by four common antioxidant tests (DPPH and ABTS assays, reducing power, and β-carotene bleaching test), and in vitro antihyperglycemic and anti-inflammatory capacities were evaluated. A total of 70 EO constituents were detected, of which 17 (8.5%) could not be identified. The H. italicum EO in this study belonged to γ-curcumene chemotype. The coefficients of determination reached the value of 0.964, demonstrating that this model could be used for prediction purposes. All applied tests showed that H. italicum EO possesses good biological activity and an interesting chemical composition. Therefore, the EO of H. italicum grown in Serbia has a potential to be used in food, cosmetic, and pharmaceutical products.
Spatial and Temporal Assessment of Nitrate-N under Rice-Wheat System in Riparian Wetlands of Punjab, North-Western India
Authors: Farmaha Bhupinder S. , Pritpal-Singh  , Bijay-Singh
Published: June 2021

The nitrate (NO3−) leaching assessment from extensive fertilizer nitrogen (N) applications to croplands is crucial to optimize fertilizer-N recommendations that do not threaten the quality of drinking groundwater. SWAP (Soil Water Atmosphere Plant), a water balance model, was linked with ANIMO (Agricultural NItrogen MOdel), a nitrate leaching model and the Geographical Information System (GIS) to assess the spatial and temporal leaching of NO3−-N from fields under rice-wheat cropping system in the riparian wetlands in the Punjab in north-western India. The results revealed that NO3−-N concentration in the groundwater exceeded the 10 mg NO3−-N L−1 limit set by the World Health Organization (WHO) for drinking water only during December–January. The verification of these results using measured values indicated that the SWAP-ANIMO model satisfactorily predicted NO3−-N concentrations in the leachate in the vadose zone. A low value of the mean absolute error (0.5–1.4) and a root mean square error (0.6–1.5) was observed between the measured and the predicted NO3−-N concentration across the soil profile during the validation at five sampling sites. The NO3−-N predictions revealed that in the long-term, the ongoing fertilizer-N management practices in the riparian wetlands will not significantly change the average NO3−-N concentration in the groundwater. The modeling approach was satisfactory for an efficient quantitative assessment of NO3−-N pollution in groundwater while accounting for the spatial and temporal variability.
An Investigation into the Perceptions of Veterinarians towards Perioperative Pain Management in Calves
Authors: van Dyke Ria , Connor Melanie , Miele Amy
Published: June 2021

While veterinarians are instrumental to the welfare of calves (Bos taurus), limited knowledge exists concerning veterinary perceptions towards perioperative pain management in calves. As a part of a larger, nationwide study investigating the perceptions of veterinarians towards calf welfare, the current work sought to quantify veterinary perceptions towards perioperative pain management, including barriers to its use, and investigate demographic influences affecting those perceptions. An electronic mixed-methods survey was completed by 104 veterinarians registered with the Veterinary Council of New Zealand. The current work revealed that most veterinarians considered a multimodal approach as the most effective method for ameliorating perioperative pain in calves, rejected the practice of differential treatment based on developmental age, and perceived that postprocedural pain persists beyond 24 h for the majority of procedures included in the survey. Despite this, veterinarians identified certain barriers that may inhibit the provision of pain mitigation on-farm, including costs, inadequate recognition of pain, and ingrained farming practices. Certain demographic effects were found to influence perceptions towards perioperative pain management, including gender, the number of years since graduation, and species emphasis. Nevertheless, the current work demonstrated considerable support among veterinarians to improve pain management protocols during routine husbandry procedures. The asymmetries that exist between the current minimum provisions of perioperative pain management and veterinary perspectives suggest that substantive improvements are necessary in order to reconcile New Zealand’s existing regulatory regime with developments in scientific knowledge.
Chicken Mesenchymal Stem Cells and Their Applications: A Mini Review
Authors: Svoradova Andrea , Zmrhal Vladimir , Venusova Eva , Slama Petr
Published: June 2021

Mesenchymal stem cells (MSCs) are multipotent progenitor cells that adhere to plastic; express the specific markers CD29, CD44, CD73, CD90, and CD105; and produce cytokines and growth factors supporting and regulating hematopoiesis. MSCs have capacity for differentiating into osteocytes, chondrocytes, adipocytes, and myocytes. They are useful for research toward better understanding the pathogenic potential of the infectious bursal disease virus, mineralization during osteogenesis, and interactions between MSCs as a feeder layer to other cells. MSCs are also important for immunomodulatory cell therapy, can provide a suitable strategy model for coculture with pathogens causing dermatitis disorders in chickens, can be cultured in vitro with probiotics and prebiotics with a view to eliminate the feeding of antibiotic growth promoters, and offer cell-based meat production. Moreover, bone marrow-derived MSCs (BM-MSCs) in coculture with hematopoietic progenitor/stem cells (HPCs/HSCs) can support expansion and regulation of the hematopoiesis process using the 3D-culture system in future research in chickens. MSCs’ several advantages, including ready availability, strong proliferation, and immune modulatory properties make them a suitable model in the field of stem cell research. This review summarizes current knowledge about the general characterization of MSCs and their application in chicken as a model organism.
Post-Thaw Sperm Quality and Functionality in the Autochthonous Pig Breed Gochu Asturcelta
Authors: Caamaño José Néstor , Tamargo Carolina , Parrilla Inmaculada , Martínez-Pastor Felipe , Padilla Lorena , Salman Amer , Fueyo Carmen , Fernández Ángel , Merino María José , Iglesias Tania , Hidalgo Carlos Olegario
Published: June 2021

Genetic resource banks (GRB) preserve the genetic material of endangered, valuable individuals or genetically relevant breeds. Semen cryopreservation is a crucial technique to reach these goals. Thus, we aimed to assess the sperm parameters of semen doses from the native pig breed Gochu Asturcelta stored at the GRB of Principado de Asturias (GRB-PA, Gijón, Spain), focusing on intrinsic and extrinsic (boar, season) factors. Two straws per boar (n = 18, 8–71 months of age) were thawed, pooled, and assessed after 30 and 150 min at 37 °C by CASA (computer-assisted sperm analysis system; motility and kinematic parameters) and flow cytometry (viability, acrosomal status, mitochondrial activity, apoptosis, reactive oxygen species, and chromatin status). The effects of age, incubation, and season on post-thawing quality were determined using linear mixed-effects models. Parameters were on the range for commercial boar breeds, with chromatin status (SCSA: fragmentation and immaturity) being excellent. Incubation decreased sperm quality and functionality. The boar age did not have a significant effect (p > 0.05), but the between-boar variability was significant (p < 0.001). The season significantly affected many parameters (motility, kinematics, viability, acrosomal status, mitochondrial activity), especially after 150 min of incubation. In general, samples collected in spring and summer showed higher quality post-thawing, the lowest in winter. In conclusion, the sperm doses from the Gochu Asturcelta breed stored at the GRB-PA showed excellent chromatin status and acceptable characteristics after thawing. Therefore, boar and seasonal variability in this autochthonous breed could be relevant for cryobank management.
Handwritten Signature Verification Method Based on Improved Combined Features
Authors: Zhou Yiwen , Zheng Jianbin , Hu Huacheng , Wang Yizhen
Published: June 2021

As a behavior feature, handwritten signatures are widely used in financial and administrative institutions. The appearance of forged signatures will cause great property losses to customers. This paper proposes a handwritten signature verification method based on improved combined features. According to advanced smart pen technology, when writing a signature, offline images and online data of the signature can be obtained in real time. It is the first time to realize the combination of offline and online. We extract the static and dynamic features of the signature and verify them with support vector machine (SVM) and dynamic time warping (DTW) respectively. We use a small number of samples during the training stage, which solves the problem of insufficient number of samples to a certain extent. We get two decision scores while getting the verification result. Finally, we propose a score fusion method based on accuracy (SF-A), which combines offline and online features through score fusion and utilize the complementarity among classifiers effectively. Experimental results show that using different numbers of training samples to conduct experiments on local data sets, the false acceptance rate (FAR) and false reject rate (FRR) obtained are better than the offline or online verification results.
Relationship between Early-Stage Features and Lifetime Maximum Intensity of Tropical Cyclones over the Western North Pacific
Authors: Lu Ren , Tang Xiaodong
Published: June 2021

The relationship between early-stage features and lifetime maximum intensity (LMI) of tropical cyclones (TCs) over the Western North Pacific (WNP) was investigated by ensemble machine learning methods and composite analysis in this study. By selecting key features of TCs’ vortex attributes and environmental conditions, a two-step AdaBoost model demonstrated accuracy of about 75% in distinguishing weak and strong TCs at genesis and a coefficient of determination (R2) of 0.30 for LMI estimation from the early stage of strong TCs, suggesting an underlying relationship between LMI and early-stage features. The composite analysis reveals that TCs with higher LMI are characterized by lower latitude embedded in a continuous band of high low-troposphere vorticity, more compact circulation at both the upper and lower levels of the troposphere, stronger circulation at the mid-troposphere, a higher outflow layer with stronger convection, a more symmetrical structure of high-level moisture distribution, a slower translation speed, and a greater intensification rate around genesis. Specifically, TCs with greater “tightness” at genesis may have a better chance of strengthening to major TCs (LMI ≥ 96 kt), since it represents a combination of the inner and outer-core wind structure related to TCs’ rapid intensification and eyewall replacement cycle.
Highly Accurate and Fast Electrochemical Detection of Scrub Typhus DNA via a Nanoflower NiFe-Based Biosensor
Authors: Li Fengzhen , Chen Delun , He Wang , Peng Juan , Cao Yang , Tu Jinchun , Wang Xiaohong
Published: June 2021

Owing to the lack of specific diagnostic methods, Scrub typhus can sometimes be difficult to diagnose in the Asia-Pacific region. Therefore, an efficient and rapid detection method urgently needs to be developed. Based on competitive single-stranded DNA over modified glassy carbon electrode (GCE), an electrochemical biosensor was established to detect the disease. The nano-flower NiFe layered double hydroxide (NiFe-LDH) modified GCE has a large specific surface area, which supported a large amount of gold nanoparticles, so that a wide linear detection range from 25 fM to 0.5 μM was obtained. The beacon DNA (B-DNA) with the same sequence as the Scrub typhus DNA (T-DNA), but labeled with methylene blue, was used to construct a competitive relationship. When T-DNA and B-DNA were present on the sensor simultaneously, they would hybridize with probe DNA in a strong competition, and the corresponding electrochemical response signal would be generated via testing. It contributed to reducing tedious experimental procedures and excessive response time, and achieved fast electrochemical detection of DNA. The strategy provides a worthy avenue and possesses promising applications in disease diagnosis.
Effects of Integrated Violence Intervention on Alexithymia, Cognitive, and Neurocognitive Features of Violence in Schizophrenia: A Randomized Controlled Trial
Authors: Hsu Mei-Chi , Ouyang Wen-Chen
Published: June 2021

Patients with schizophrenia and repetitive violence express core impairments that encompass multiple domains. To date, there have been few interventions integrating neurocognition, social cognition, alexithymia, and emotion regulation together as an approach to manage repetitive violence. The aim of this open-label randomized controlled trial was to examine more comprehensively the effectiveness of a novel Integrated Cognitive Based Violence Intervention Program on management of repetitive violence in patients with schizophrenia (vSZ). Sixty recruited patients were aged ≥20 years, diagnosed with schizophrenia for >2 years, had repetitive violent behavior within one year, and were psychiatrically hospitalized. The vSZ patients were randomly allocated to two groups and received either the intervention or treatment as usual. The intervention module, consisting of all defined 11 cognitive and social cognitive domains as well as emotion regulation, which were grouped into four modules. The intervention placed emphasis on the patients’ behavioral problems or intrinsic conflicts in relation to repetitive violence. The results indicate a statistically significant trend toward reducing impulsivity, anger with resentment, physical aggression, suspicion, and hostility (p < 0.05). The intervention significantly alleviated the intensity of cognitive failure, improved the management of alexithymic features and attribution styles and errors, and fostered adequate decision-making styles and emotion regulation capacity (p < 0.05). The intervention, when applied in conjunction with psychiatric standard care, could exert synergistic effects on alexithymia and cognitive, clinical, and neurocognitive features of repetitive violence in schizophrenia. This intervention provided patients a more active role to manage their violent behavior with the involvement of alexithymia.
Treatment Realities of Headache Disorders in Rural Germany by the Example of the Region of Western Pomerania
Authors: Thiele Anne , Strauß Sebastian , Angermaier Anselm , Klehr Lara , Bartsch Luise , Kronenbuerger Martin , Schmidt Sein , Fleischmann Robert
Published: June 2021

(1) Background: Headache disorders are among the most disabling medical conditions but the supply with experienced providers is outpaced by the demand for service. It is unclear to what extent particularly patients in rural regions are affected by limited access to comprehensive care. Furthermore, it is unknown what role general practitioners (GPs) play in headache care. (2) Methods: First-time consultations to a specialised headache clinic at a tertiary care centre were asked to participate. Their socio-demographic background, general and headache-specific medical history, disability and quality of life (QoL) were assessed. Additionally, 176 GPs in neighbouring districts were contacted regarding headache management. (3) Results: We assessed 162 patients with first-time consultations (age 46.1 ± 17.0 years, 78.1% female), who suffered from migraine (72%), tension type, cluster and secondary headaches (each 5–10%). About 50% of patients received a new headache-diagnosis and 60% had treatment inconsistent with national guidelines. QoL was significantly worse in all domains compared to the general population. About 75% of GPs see headache patients at least several times per week, and mostly treat them by themself. (4) Conclusions: More than every second headache patient was neither correctly diagnosed nor received guideline adherent treatment. Headache-related disability is inferior to what is expected from previous studies. Access to specialised health care is more limited in rural than in urban regions in Germany and GPs request more training.
Effects of Metal Fasteners of Ventilated Building Facade on the Thermal Performances of Building Envelopes
Authors: Alghamdi Abdulrahman , Alharthi Hamzah , Alanazi Abdulelah , Halawani Mohammad
Published: June 2021

Thermal bridging in the building envelope is one of the main causes of energy losses, even in high-efficiency ventilated building façades. In this study, the effects of point-thermal bridges attributed to metal fasteners on the heat transferred through different types of bricks were predicted. All the structural details of the substrate wall were included as well. This was accomplished with a multi-scale, finite element modelling approach used to enhance the thermal insulation efficiency of the building envelope. The effects of the metal fastener length, diameter, density and location were examined to elucidate any opportunity to minimize the heat losses caused by thermal bridging. The results demonstrated that increases in the lengths of fasteners yielded higher energy losses compared with those generated when the diameter increased. Additionally, metal fasteners caused higher energy losses by up to 30% when fixed on mortar, compared with the energy losses incurred when they were fixed on bricks.
The Influence of Chemical Activators on the Hydration Behavior and Technical Properties of Calcium Sulfoaluminate Cements Blended with Ground Granulated Blast Furnace Slags
Authors: Marroccoli Milena , Telesca Antonio
Published: June 2021

The manufacture of Ordinary Portland cement (OPC) generates around 8% of the global CO2 emissions related to human activities. The last 20 years have seen considerable efforts in the research and development of methods to lower the carbon footprint associated with cement production. Specific focus has been on limiting the use of OPC and employing alternative binders, such as calcium sulfoaluminate (CSA) cements, namely special hydraulic binders obtained from non-Portland clinkers. CSA cements could be considered a valuable OPC alternative thanks to their distinctive composition and technical performance and the reduced environmental impact of their manufacturing process. To additionally reduce CO2 emissions, CSA cements can also be blended with supplementary cementitious materials. This paper investigates the influence of two separately added chemical activators (NaOH or Na2CO3) on the technical properties and hydration behavior of four CSA blended cements obtained by adding to a plain CSA cement two different ground granulated blast furnace slags. Differential thermal-thermogravimetric, X-ray diffraction and mercury intrusion porosimetry analyses were done, along with shrinkage/expansion and compressive strength measurements.