bluuebunny/crossref_metadata_2025 huggingface dataset:
DIFFERENTIAL DIAGNOSIS OF THE FLOPPY INFANT SYNDROME
Authors:   Pirogov Russian National Research Medical University, Moscow, Russia, Dumova S.V. , Chugunova O.L. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Semenova N.A. ,   Academician N.P. Bochkov Research Centre of Medical Genetics (RCMG) of the Russian Academy of Sciences, Moscow, Russia, Komleva N.A. ,   Perinatal Center with the Moscow City Clinical Hospital No. 24 of the Moscow Department of Healthcare, Moscow, Russia, Mironuk O.V. ,   Perinatal Center with the Moscow City Clinical Hospital No. 24 of the Moscow Department of Healthcare, Moscow, Russia, Shagiazdanova A.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Khokhlova A.M. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Shumilov P.V. ,   Pirogov Russian National Research Medical University, Moscow, Russia
Published: January 2022

The article presents data on the etiology, pathogenesis, characteristic features of clinical manifestations and diagnostics of conditions leading to the appearance of the floppy infant symptom complex. This pathological condition does not have a single nosological form and is characterized by severe muscle hypotonia. Depending on the severity of muscle hypotension and muscle weakness, a central or peripheral mechanism for the development of hypotension can be assumed. Considering that more than 100 diseases can hide behind the mask of a floppy infant syndrome, a clear algorithm for the differential diagnosis of muscle hypotension is required. The article presents literature data on the possible diagnosis of various conditions accompanied by muscular hypotension during neonatal period, and highlights the necessary range of examinations for various types of central and peripheral hypotension. Early verification of the diagnosis can help not only avoid death, but also significantly improve the quality of life of the child. A clinical observation of the Prader–Willi syndrome is presented, demonstrating the possibilities of differential diagnosis of the floppy infant syndrome in the conditions of the perinatal center.
SELECTED CLINICAL CHARACTERISTIC FEATURES OF TUBERCULOSIS IN CHILDREN OF PRESCHOOL AND PRIMARY SCHOOL AGE (EXPERIENCE OF THE OMSK REGION)
Authors:   Omsk State Medical University, Omsk, Russia, Aroyan A.R. ,   Omsk Oblast Regional Clinical Anti-Tuberculosis Dispensary, Omsk, Russia, Mordik A.V. ,   Omsk State Medical University, Omsk, Russia,   National Medical Research Center for Phthisiopulmonology and Infectious Diseases of the Ministry of Healthcare of Russia, Moscow, Russia
Published: January 2022

Objective of the study: to evaluate the structure of clinical forms of tuberculosis (TB) and the results of immunodiagnostics in children of preschool and primary school age. Materials and methods of research: a cohort retrospective non-randomized controlled study was conducted: 609 children aged 4–11 years who fell ill with active TB during the period from 2000 to 2020 were included in the study, groups were formed by 4–6 and 7–11 years of age. Results: in children of comparable ages, statistically significant differences were obtained in the frequency of TB diagnosis of the respiratory organs – 94.7% and 89.9% in groups (p=0.037), in particular, TB of the intrathoracic lymph nodes – 85.7% and 75.3% (p=0.003) and primary tuberculosis complex – 13.2% and 23.3% (p=0.003) and isolated extrapulmonary TB – the proportion was 5.6% and 1.3% of cases (p=0.008). According to the results of immunodiagnostics, 57.1% and 55.6% of children were identified, and in risk groups – 0.7% and 3.3% (p=0.043). There were no statistically significant differences in the results of the Mantoux test at the pre-hospital and hospital stages. The Mantoux test upon admission to the hospital was positive in 96.7% and 97.3% of cases (p>005), the test with the recombinant tuberculosis allergen (RTA) – in 99.1% and 95.5%. In patients aged 4–6 years, at discharge from the hospital, statistically significant differences were obtained as a result of weakly positive reactions of the test with ATP – 23.9% versus 6.7% of cases in children aged 7–11 years (p=0.008). Conclusion: in children aged 4–6 and 7–11 years, there is a favorable pattern of clinical forms of TB. The main method for detecting TB in children aged 4 to 11 years is immunodiagnosis, but the cases of the disease detected during the contact examination, despite the course of preventive chemotherapy, are alarming. The RTA test at the stage of TB detection gives a higher percentage of hyperergic reactions than the Mantoux test, which indicates its greater diagnostic significance. When monitoring TB treatment, samples with RTA and tuberculin react the same way in terms of reducing the frequency of hyperergic reactions.
DISEASES ASSOCIATED WITH MUTATIONS IN THE FILAMIN A GENE: THE DIFFICULT PATH TO DIAGNOSIS (TWO CLINICAL CASES)
Authors:   People’s Friendship University of Russia, Moscow, Russia, Ovsyannikov D.Yu. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Kotlukova N.P. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Telezhnikova N.D. ,   Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia, Trunina I.I. ,   Pirogov Russian National Research Medical University, Moscow, Russia,   Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia, Miklashevich I.M. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Shcherbakova N.V. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Zaklyaz’minskaya E.V. ,   Russian Scientific Surgery Center named after Academician B.V. Petrovskiy with the Russian Academy of Sciences, Moscow, Russia, Shestak A.G. ,   Russian Scientific Surgery Center named after Academician B.V. Petrovskiy with the Russian Academy of Sciences, Moscow, Russia, Basargina E.N. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Savost’yanov K.V. ,   National Medical Research Center for Children’s Health, Moscow, Russia, Zhestkova M.A. ,   People’s Friendship University of Russia, Moscow, Russia, Karpenko M.A. ,   People’s Friendship University of Russia, Moscow, Russia, Illarionova T.Yu. ,   People’s Friendship University of Russia, Moscow, Russia, Gazalieva L.R. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Ksandopulo E.M. ,   People’s Friendship University of Russia, Moscow, Russia, Mamaeva E.A. ,   V.A. Almazov National Medical Research Centre of the Ministry of Healthcare of Russia, Saint Petersburg, Russia, Abramyan M.A. ,   People’s Friendship University of Russia, Moscow, Russia,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Miroshnichenko V.P. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Gorev V.V. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Fisenko A.P. ,   National Medical Research Center for Children’s Health, Moscow, Russia
Published: January 2022

The article presents the first descriptions of observations in the Russian Federation, the difficult path to diagnosis in two young girls with diseases associated with mutations in the filamin A gene, characterized by damage to the central nervous system (periventricular nodular heterotopy), lungs (interstitial emphysematous lesion due to impaired growth), cardiovascular system (open arterial duct, high pulmonary hypertension, insufficiency of heart valves, large vessels). Clinical and anamnestic data, the results of laboratory and instrumental diagnostic methods, including molecular genetic ones, which allowed to identify unique, previously undescribed mutations, the characteristics of the course of the disease, the treatment being carried out, are presented.
CONGENITAL INFECTION CAUSED BY THE SARS-CоV-2: LITERATURE REVIEW AND FIRST CLINICAL CASE
Authors:   Kaluga Oblast Regional Clinical Hospital, Kaluga, Russia, Karpova A.L. , Kovaleva M.A. ,   Yaroslavl Oblast Regional Perinatal Center, Yaroslavl, Russia, Karpov N.Yu. ,   Tutayev Central District Hospital, Tutayev, Tutayevsky District, Yaroslavl Oblast, Russia, Mostovoi A.V. ,   Kaluga Oblast Regional Clinical Hospital, Kaluga, Russia, Chelnokova I.M. ,   Yaroslavl Oblast Regional Perinatal Center, Yaroslavl, Russia, Kirdyanov S.Yu. ,   Yaroslavl Oblast Regional Perinatal Center, Yaroslavl, Russia
Published: January 2022

COVID-19 is a disease caused by the novel SARS-CoV-2, is a severe systemic thrombotic syndrome with respiratory tract damage that emerged in 2019 in China with the development of a subsequent pandemic. Over the past two years, very little information has been accumulated on the prevalence, transmission routes, and the clinical picture of the disease among newborn infants. Given the limited data in the domestic literature, authors present not only a description of the first clinical observation of confirmed new coronavirus infection in a premature newborn, but also a brief review of the literature on the description of the epidemiology, clinic and methods of therapy for COVID-19 in infants.
CHARACTERISTIC FEATURES OF THE GENOTYPE OF EXTREMELY PREMATURE CHILDREN WITH ADVERSE OUTCOME
Authors:   V.N. Gorodkov Ivanovo Research Institute for Motherhood and Childhood, Ivanovo, Russia, Shilova N.A. , Fetisova I.N. ,   V.N. Gorodkov Ivanovo Research Institute for Motherhood and Childhood, Ivanovo, Russia,   Ivanovo State Medical Academy, Ivanovo, Russia, Mezhinskiy S.S. ,   V.N. Gorodkov Ivanovo Research Institute for Motherhood and Childhood, Ivanovo, Russia, Chasha T.V. ,   V.N. Gorodkov Ivanovo Research Institute for Motherhood and Childhood, Ivanovo, Russia, Kharlamova N.V. ,   V.N. Gorodkov Ivanovo Research Institute for Motherhood and Childhood, Ivanovo, Russia, Fetisov N.S. ,   V.N. Gorodkov Ivanovo Research Institute for Motherhood and Childhood, Ivanovo, Russia, Ratnikova S.Yu. ,   V.N. Gorodkov Ivanovo Research Institute for Motherhood and Childhood, Ivanovo, Russia
Published: January 2022

The aim of the research was to study the polymorphism of the genes of the detoxification system and genes of the main histocompatibility complex HLA class II in premature infants with a birth weight of less than 1500 g and a gestation period of less than 32 weeks. Materials and methods of research: 103 extremely premature infants without congenital malformations, having respiratory disorders and requiring respiratory therapy in one volume or another, were under observation. All children were divided into 2 groups: 1st – 81 extremely premature babies with favorable outcome (recovery); 2nd – 22 children with unfavorable outcome (death, disability). Results: an association was established between the presence of DQA1*0301 alleles in the genotype and the development of unfavorable outcome in extremely premature infants with respiratory pathology (p=0.041). In addition, the genotype GSTM1+/+ GSTT1+/+ DRB1*13 DQA1*0301 DQB1*0602 was determined only in children with poor outcomes (p=0.041). The presence of genotypes GSTM1 – GSTT1+/+ DRB1*11 DQA1*0501 DQB1*0301 and GSTM1 – GSTT1+/+ DRB1*15 DQA1*0102 DQB1*0602 17 times, and the presence of the DQA1*0401 allele 8 times increases the risk of death (p=0.028).
AUTOIMMUNE POLYENDOCRINE SYNDROME TYPE 2 IN A 17 YEAR OLD GIRL: A BRIEF LITERATURE REVIEW AND CASE REPORT
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Kovarenko M.A. , Yuditskaya T.A. ,   Omsk Oblast Regional Children's Clinical Hospital, Omsk, Russia,   Omsk State Medical University, Omsk, Russia
Published: January 2022

Autoimmune polyglandular syndromes (APSs) are diseases involving damage to two or more endocrine glands, in the development of which the main role is played by impaired immune response. It can take up to several years between the development of individual components of the syndrome, and the symptoms of disorders are often erased and nonspecific, so it is often difficult to diagnose. APSs are subdivided into juvenile and adult subtypes. The article presents a clinical observation of the development of the full form of APSs type 2, which is typical for adults, in a teenage girl by age 17. Special attention is paid to diagnostic issues and the features of the management of patients with APSs type 2.
DETECTION OF THE REPUBLIC OF NORTH OSSETIA – ALANIA’S FIRST CASE OF MUCOPOLYSACCHARIDOSIS TYPE VI: CLINICAL CHARACTERISTICS AND TREATMENT RESULTS
Authors:   North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, Russia, Tebieva I.S. ,   Medical and Genetic Consultative Department with the Republican Children's Clinical Hospital of the Republic of North Ossetia-Alania, Vladikavkaz, Republic of North Ossetia-Alania, Russia, Bazrova F.V. ,   North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, Russia,   Medical and Genetic Consultative Department with the Republican Children's Clinical Hospital of the Republic of North Ossetia-Alania, Vladikavkaz, Republic of North Ossetia-Alania, Russia, Gabisova Yu.V. ,   Medical and Genetic Consultative Department with the Republican Children's Clinical Hospital of the Republic of North Ossetia-Alania, Vladikavkaz, Republic of North Ossetia-Alania, Russia, Turieva S.V. ,   North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, Russia, Zinchenko R.A. ,   Academician N.P. Bochkov Research Centre of Medical Genetics (RCMG) of the Russian Academy of Sciences, Moscow, Russia,   National Research Institute of Public Health named after N.A. Semashko, Moscow, Russia
Published: January 2022

Mucopolysaccharidoses (MPS) are a group of rare hereditary metabolic diseases caused by the accumulation of glycosaminoglycans in organs and tissues. Due to severe disabling course and the presence of specific enzyme replacement therapy for some types, they are included in the list of orphan diseases. The quality of life of patients with MPS improves significantly on condition of early diagnosis, timely prescription of pathogenetic therapy and treatment of comorbidities. From 2000 to 2020 in the Republic of North Ossetia – Alania, 165,149 children were born. During the study period, one case of MPS type VI was registered. Thus, the frequency of this pathology was 1:165,149 newborns. Enzyme replacement therapy for the observed patient is carried out for 6 years. Considering the positive dynamics of growth, a decrease in joint stiffness, no changes in the hemogram, a decrease in the size of the liver in dynamics, a stable picture according to the MRI of the brain in the observed patient, therapy with Naglazim should be recognized as effective.
Vitamin C and cancer risk and treatment
Authors: Dębska-Szmich Sylwia , Potemski Piotr
Published: January 2022

Vitamin C (L-ascorbic acid) works as a strong reductant, radical scavenger, and protector of cell membranes against primary peroxidative damage in tissues and in the extracellular fluid. L-ascorbic acid is involved in the synthesis of collagen and many other biologically relevant substances, enzyme activity, xenobiotic detoxification, and prevention of forming carcinogenic nitrosamines. It also plays a role in the immune system. Numerous data indicate that cancer patients suffer from vitamin C deficiency. Studies show that people with a low vitamin C intake have an increased risk of head and neck cancers as well as lung, gastric, pancreatic, cervical, rectal, or breast cancer. On the other hand, there is no clinical evidence to support the thesis that antioxidant supplements (including vitamin C) prevent cancer. Observational trials investigating high doses of intravenous L-ascorbic acid in previously treated cancer patients have shown that it allows an increase in quality of life and may improve physical, mental, and emotional functions, as well as reducing adverse effects of standard anticancer treatment, including fatigue, nausea, vomiting, and appetite loss. So far, there were a few randomized controlled trials and they have not reported any statistically significant improvements in the overall or progression-free survival with vitamin C, as compared to the control arm. However, preclinical data indicating a role of L-ascorbic acid in modulation of immune response and its involvement in epigenome remodeling suggest its new potential clinical applications in cancer patients, especially in combination with immunotherapy. It seems reasonable to further investigate the value of vitamin C as a supportive treatment or in combination with anticancer targeted therapy.
Salivary Gland Protein Expression after Bion-M1 and Space Shuttle STS-135 Missions
Authors: Mednieks Maija , Khatri Aditi , Hand Arthur R.
Published: January 2022

Secretory proteins produced by salivary glands are stored in granules and released into saliva. Rodent salivary glands are a reliable experimental model because they are morphologically and functionally similar to those of humans. To determine if the effects of microgravity on secretory proteins are increased on extended flights, their expression in mouse parotid glands, morphological, immunocytochemical, and biochemical/molecular methods were employed. Acinar cells of STS-135 (13 day) and Bion-M1 (30 day) flight animals showed an increase of autophagy and apoptosis, while duct cells contained vacuoles with endocytosed proteins. In STS-135, decreases were seen in the regulatory subunit of type II protein kinase A (RII) by Western blotting, and demilune cell and parotid protein (DCPP) and α-amylase (p<0.01) by immunogold labeling, while proline-rich proteins (PRPs, p<0.001) and parotid secretory protein (PSP, p<0.05) were increased. These results suggest microgravity effects on secretion are function-dependent. Microarray analyses showed significant changes in the expression of a number of genes, including components of the cyclic-3’,5’,-adenosine monophosphate (cyclic AMP) signaling pathway. Compared to habitat ground controls, mice from both flights exhibited altered expression of cyclic AMP-specific phosphodiesterases, adenylate cyclase isoforms, and several A-kinase anchoring proteins. Bion-M1 flight mice showed increases in gene expression for lysozyme and amylase, a decrease in PRPs, and RII expression was unchanged from control values. Secretory protein expression is altered by travel in space, representing a reversible adjustment to microgravity conditions. Ultimately, the goal is to develop a test kit using saliva — an easily obtained body fluid — to assess the physiologic effects of travel in space.
The Effect of Magnetic Water on The Production and Physiological Traits in The Quail (Coturnix coturnix (Linnaeus, 1758))
Authors: Hassan Khalid H. , Assi Saraa A. , Abdul-Kareem Tabark B. , Baker Zakaria K.
Published: January 2022

An experiment is conducted to determine the effect of magnetic water on the production performance and blood characteristics of common quail, Coturnix coturnix (Linnaeus, 1758). The experimental treatments included T1 = control treatment, T2 = drinking water magnetization at1000 gauss, T3 = drinking water magnetization at 1500 gauss, T4 = diet sprayed with magnetized water 1000 gauss, T5 = diet sprayed with magnetized water 1500 gauss, each treatment with three replicates. The results showed significant superiority of control group in the body weight, weight gain and feed intake compared with treated groups. The egg shell thickness of T2 showed a significant decrease compared to other groups. The third treatment showed a significant superiority in red blood cell count compared with T1, T4 and T5, while T5 appeared significant reduction in white blood cell count compared with other treatments. There was significant reduction in blood glucose, total protein, cholesterol, and triglyceride in T4 compared with control.
Characterization of Cr2O3 Nanoparticles Prepared Using Cauliflower Extract by Two Methods
Authors: Ali Saja Q. , Aziz Wisam J. , Sabry Raad S.
Published: January 2022

Chromium oxide nanoparticles were synthesized using cauliflower extract by two methods: simple chemical method and the sol-gel method. These technologies are  new, environmentally friendly and cheap. Cauliflower contains plant materials and biomolecules (chromium, phenols, alkalis, vitamins, amino acids, quinones, etc. (that convert chromium chloride hexahydrate (CrCl3.6H2O) into chromium nanoparticles. The plant extracts also act as diluents, stabilizers and anti-caking agents. X-ray diffraction (XRD) analysis showed that the size of the crystals decreased from (36.1 to 57.8) nm  using the simple chemical method to (13.31 to 20.68) nm of Cr2O3 using sol-gel. The  scanning electron microscopy (SEM) showed that  Cr2O3 NPs of the simple chemical method were Nano layers with (130.3) nm,  while  the Cr2O3 NPs of the sol-gel method  were spherical or semispherical in shape with a particle size of (14.89 to 39.08) nm. The results  obtained have no matches in the reported literature.. Ultraviolet-visible (UV-Vis) showed that the band gap energy  of  Cr2O3 NPs  of the simple chemical method was 2.5 eV, while it was 3.4 eV for Cr2O3 NPs of the sol gel method . Cr2O3 NPs  of  high purity , small particle size, and large energy gap  were obtained from the  sol-gel method  This means that the NPs from the sol gel method were better than those of  the simple chemical method. The study revealed that the Chromium oxide nanoparticles synthesized using cauliflower extracts could be used as antibacterial agent for human pathogenic bacteria
PERGESERAN KECAKAPAN BERTUTUR DI KALANGAN MAHASISWA BAHASA AKIBAT INTERAKSI BAHASA INDONESIA, BAHASA DAERAH, DAN BAHASA ASING
Authors: Irawan Yusup
Published: January 2022

This study aims to examine the existence of language shifts through shifts in speaking skills due to interactions between Indonesian, regional languages, and foreign languages. The data collection technique used is the recording technique as the main technique, while the interview and direct observation techniques are additional techniques. The respondents of this study were 34 students of the Indonesian language study program and the foreign language study program. Speech data were analyzed with three aspects of oral language skills, namely (2) speech tempo (prosody or intonation), (2) fluency, and (3) lexical (Itkonen, 2010:15-17). The results of the analysis show that there has been a shift in speaking skills from regional languages to Indonesian for all groups of respondents. Even students who are engaged in foreign languages are on average more fluent in foreign languages than in regional languages. These are indicators of a shift in regional languages to Indonesian and a shift in regional languages to foreign languages among this group of students. It can be formulated that the lower the speaking skill of a language is mastered by the speaker, the more vulnerable the language is to be shifted by a language that is more capable of being mastered by the speaker.
KRITIK SOSIAL DALAM NOVEL ORANG-ORANG BIASA KARYA ANDREA HIRATA
Authors: Yulianto Agus
Published: January 2022

The purpose of this study is to find out the forms of social criticism contained in the novel Orang-Orang Biasa by Andrea Hirata. The problem in this research is how the forms of social criticism contained in the novel Orang-Orang Biasa by Andrea Hirata. This research uses a descriptive qualitative method by using the sociology of literature approach. Based on the results of the analysis it can be seen that the forms of social criticism contained in this novel are: 1. economic criticism; 2. criticism of the rise of crime; and 3. criticism of education.
PENDIDIKAN KARAKTER DALAM CERITA FABEL BANJAR
Authors: Saefudin Saefuddin
Published: January 2022

Masalah dalam penelitian ini ialah bagaimana bentuk pendidikan karakter dalam  cerita fabel Banjar. Tujuan penelitian ini ialah mengetahui dan mendeskripsikan bentuk  pendidikan karakter  dalam cerita fabel Banjar. Masyarakat Banjar di Kalimantan Selatan memiliki banyak cerita rakyat, salah satunya ialah cerita fabel. Fabel merupakan bagian dari sastra lisan dan sarana yang baik untuk dijadikan contoh pemerolehan pendidikan karakter, misalnya mengenai budi pekerti (sopan santun). Budi pekerti itu kita dapatkan melalui peran tokoh-tokoh di dalam cerita. Oleh karena itu, fabel sangat penting untuk dijadikan bahan pengayaan literasi bagi anak dan sebagai bahan penelitian, khususnya bidang sastra. Penelitian ini menggunakan metode deskriptif-kualitatif. Metode deskriptif-kualitatif ialah suatu metode untuk memperoleh informasi tentang pendidikan karakter tokoh yang terdapat dalam cerita fabel Banjar. Hasil penelitian menunjukkan bahwa gambaran tentang pendidikan karakter dapat diperoleh melalui tokoh cerita fabel Banjar.Kata kunci: Pendidikan karakter, fabel Banjar
BAHASA BALI DI TENGAH MASYARAKAT MULTIETNIS: Kajian Vitalitas Bahasa
Authors: Parwati Sang Ayu Putu Eny , Sudiartha I Wayan
Published: January 2022

Penelitian ini mengungkap tentang penggunaan bahasa Bali (BB) oleh masyarakat multietnis di Kecamatan Melaya, Kabupaten Jembrana. Tujuan penelitian ini adalah untuk mengetahui pilihan bahasa masyarakat etnis Bali dan masyarakat nonetnis Bali sehingga vitalitas BB dapat diketahui berdasarkan nilai rata-rata indikatornya. Vitalitas BB pada setiap indikatornya dideskripsikan dengan menerapkan metode kuantitatif melalui penyebaran kuesioner yang memuat pilihan bahasa dan vitalitas bahasa. Tahapan pengolahan data kuantitatif dimulai dengan penyuntingan, pengodean, dan pemrosesan data dengan hitungan statistik deskriptif. Hasilnya, pada tujuh ranah penggunaan bahasa oleh responden etnis Bali sebagian besar memilih menggunakan bahasa Indonesia (BI) dan sebagiannya lagi memilih bahasa campuran (BC) antara BI dan BB, baik pada ranah formal maupun nonformal.Sementara itu, BB juga menjadi salah satu bahasa yang dipilih dan digunakan oleh responden nonetnis Bali pada ranah ketetanggaan, lingkungan kerja, pemerintahan, teransaksi, dan media sosial, sedangkan pilihan terhadap bahasa daerah lain (BDL) hanya digunakan pada ranah rumah tangga. Hal tersebut menunjukkan bahwa walaupun bukan merupakan masyarakat etnis Bali, responden mampu dan paham berkomunikasi menggunakan BB. Pada sepuluh indikator yang termasuk dalam vitalitas bahasa, BB pada indikator jumlah penutur, posisi dominan masyarakat penutur, sikap bahasa, pembelajaran, dan dokumentasi masuk dalam kriteria aman. Sementara itu, pada indikator kontak bahasa, bilingualitas, dan ranah penggunaan bahasa, BB masuk dalam kriteria stabil, tetapi perlu dirawat. Namun, pada indikator regulasi dan tatangan baru, BB masuk dalam kriteria mengalami kemunduran.
What makes a medical school socially accountable? A qualitative thematic review of the evaluation of social accountability of medical schools in the Eastern Mediterranean Region
Authors: Abdalla Mohamed , Taha Mohamed , Wadi Majed , Khalafalla Husameldin
Published: January 2022

Background: The World Health Organization Regional Office for the Eastern Mediterranean Region established social accountability as one of its strategic directions for medical education in 2015, and individual countries have been contributing to ongoing social accountability endeavours. Aims: This study aimed to identify themes related to compliance with social accountability concepts in the countries of the Eastern Mediterranean Region (EMR) based on published papers Methods: Thematic analysis of qualitative studies was done following a scoping review of published papers in the EMR over the period 1995–2021. CINAHL, Google Scholar, PubMed, Scopus, and Web of Sciences were searched along with a manual search for articles from reference lists. The Enhancing Transparency in Reporting the Synthesis of Qualitative Research ENTREQ statement guided the review. Results: The reviewed studies (n = 3) were from 3 countries in the EMR: Egypt, Saudi Arabia, and Sudan. These studies identified 7 key themes: mission and governance, communication with stakeholders, a community-oriented and community-based curriculum, provision of health services, responding to emerging community health needs, impactful faculty and student research and gaps to be addressed. Conclusions: Despite the call to reorient health profession schools to be responsive to the community and health system needs, only 3 countries in the EMR reported their efforts to move towards social accountability. Urgent action needs to be taken by medical education leaders in the Region to support colleges in their compliance with social accountability concepts.
Study on Extension of the 6-DOF Measurement Area for a Model Ship by Developing Auto-tracking Technology for Towing Carriage in Deep Ocean Engineering Tank
Authors: Jung Jae-Sang , Lee Young-guk , Seo Min-guk , Park In-Bo , Kim Jin-ha , Kang Dong-bae
Published: January 2022

The deep ocean engineering basin (DOEB) of the Korea Research Institute of Ship and Ocean Engineering (KRISO) is equipped with an extreme-environment reproduction facility that can analyze the motion characteristics of offshore structures and ships. In recent years, there have been requirements for a wide range of six-degree-of-freedom (6-DOF) motion measurements for performing maneuvering tests and free-running tests of target objects (offshore structures or ships). This study introduces the process of developing a wide-area motion measurement technology by incorporating the auto-tracking technology of the towing carriage system to overcome the existing 6-DOF motion measurement limitation. To realize a wide range of motion measurements, the automatic tracking control system of the towing carriage in the DOEB was designed as a speed control method. To verify the control performance, the characteristics of the towing carriage according to the variation in control gain were analyzed. Finally, a wide range of motions was tested using a model test object (a remotely operated vehicle (ROV)), and the wide-area motion measurement technology was implemented using an automatic tracking control system for a towing carriage.
Analisis Jaringan Angkutan Kota Di Kota Cimahi
Authors: Ferry Rusgiyarto
Published: January 2022

Angkutan kota merupakan sarana transportasi yang paling penting dalam penunjang mobilitas penduduk terutama untuk penggunaan jasa angkutan. Angkutan kota ini pada setiap harinya selalu mengangkut penumpang terutama pada jam-jam sibuk yaitu pada pagi dan sore hari. Untuk dapat menyediakan pelayanan angkutan kota yang efektif dan efisien maka diperlukan perencanaan operasional pelayanan angkutan kota dengan sebaik mungkin, oleh karena itu maka diperlukan adanya evaluasi mengenai jaringan angkutan kota untuk mengetahui apakah karakterisrtik pelayanan angkutan kota serta daerah pelayanan yang terlayani sudah memenuhi syarat yang diijinkan.

Angkutan kota merupakan sarana transportasi yang paling penting dalam penunjang mobilitas penduduk terutama untuk penggunaan jasa angkutan. Angkutan kota ini pada setiap harinya selalu mengangkut penumpang terutama pada jam-jam sibuk yaitu pada pagi dan sore hari. Untuk dapat menyediakan pelayanan angkutan kota yang efektif dan efisien maka diperlukan perencanaan operasional pelayanan angkutan kota dengan sebaik mungkin, oleh karena itu maka diperlukan adanya evaluasi mengenai jaringan angkutan kota untuk mengetahui apakah karakterisrtik pelayanan angkutan kota serta daerah pelayanan yang terlayani sudah memenuhi syarat yang diijinkan. Telah dilakukan analisa mengenai jaringan angkutan kota di Kota Cimahi dengan lingkup penelitian mengenai karakteristik pelayanan angkutan kota seperti waktu antara kendaraan, faktor muat, frekuensi, faktor keterisian kendaraan, kecepatan dan waktu tempuh.
3B Yazıcılarda Kullanılan Farklı Tip Ekstüderlerin ANSYS Programı ile Termal Analizlerinin Gerçekleştirilmesi
Authors: DEMİR Hasan , COŞGUN Atıl Emre
Published: January 2022

Bu çalışmanın amacı, 3B yazıcılarda ticari olarak kullanılan J-Head ekstrüder ve Volcano ekstrüderlerin ANSYS sonlu elemanlar yazılımı ile modellerin kararlı hal termal analizlerini gerçekleştirmek, modellerin eksiklikleri ve birbirlerine göre üstünlüklerini belirlemektir. Modellerin tasarımsal farklılıkları ve geometrik özellikleri farklı termal davranışlar göstermesine neden olmaktadır. Başlangıç koşulları ve sınır şartları her iki model için aynı olması sağlanmış, böylelikle diğer değişkenlerin sabit olmasına bağlı olarak tasarımların termal analizleri ön plana çıkarılmıştır. Termal analiz ile modellerin tasarımlarının baskı malzemesinin füzyonu üzerindeki etkileri incelenmiştir. Analiz sonuçları, modellerin avantaj ve dezavantajlarını ortaya koymuş ve gelecekte yapılabilecek yeni tasarımlar için bilgi kaynağı oluşturmuştur.
De novo transcriptome assembly reveals three alternative oxidase encoding genes in Nymphaea alba L.
Authors: ÜNLÜ Ercan Selçuk , YILDIZ Gülgez Gökçe
Published: January 2022

Water lilies are aquatic, ornamental and economically valuable plants classified under Nymphaea genus. Nymphaea alba L., white water lily, has a special focus since it is a member of basal angiosperms. Alternative oxidase (AOX) proteins are the terminal oxidases in the electron transport chain of plants. Identification of alternative oxidase encoding genes for basal angiosperms is important to increase the quality of phylogenetic studies. However, AOX encoding genes were yet to be discovered for N. alba. In this study, we aimed to identify alternative oxidase encoding genes in N. alba by performing transcriptome analysis. Annotation of 272,934 unigenes with Trinotate tool revealed 77 transcripts with AOX domains characterized in known alternative oxidases. Blast analysis of these 77 sequences with known AOX proteins revealed three distinct AOX genes (AOX1, AOX2 and AOX4) in N. alba. After in silico subcellular localization analysis of three identified AOX proteins, AOX1, AOX2 are predicted as mitochondrial while AOX4 is a plastidic alternative oxidase protein. Template-based structural modeling results showed that all identified proteins are statistically similar to known structure models of corresponding AOXs.
Operating Room Scheduling by Using Hybrid Genetic Algorithm
Authors: TİMUÇİN Tunahan , BİROĞUL Serdar
Published: January 2022

Hospitals are among the most important institutions of today. For hospitals, efficient use of operating rooms is of great importance. Efficient use of operating rooms is a problem that needs to be solved. The operating room scheduling problem is a very complex problem with large number of constraints. This type of problem called as NP-Hard type problem. NP-Hard type problems do not consist of polynomial values. Therefore, the solution of these problems is very complex and difficult. Solutions consisting of polynomial values can be solved effectively with existing mathematical methods. However, more effective algorithms were needed to solve NP-hard type problems. As a result of the studies, many heuristic, meta-heuristic algorithms such as Genetic Algorithm, Particle Swarm Optimization, Simulated Annealing, Taboo Search Algorithm have been developed to solve the complexity of NP-Hard problems. In this article, the operating room scheduling problem solved with a hybrid genetic algorithm. In this solution, it shows how the algorithm affects the solution area in the changes in the number of surgeons, operating rooms and operating room reservations, which are among the operating room parameters. In the developed software, C# programming language has been preferred in order to provide comfortable use of the end user.
Consumer Perception Towards Localization of MNC Fast Food Chain in Pakistan
Authors: Channa Mehwish , Pitafi Adnan , Tunio Ghazala
Published: January 2022

The study tests the consumer preferences in Pakistan (a developing economy) to know about the consumer’s choice and localization of MNC to have clear understanding of entering in to the new market following the local culture of the country. Study focuses on the multinational fast food outlets. The research is grounded on both primary & secondary information and primary data is collected randomly from 412 fast food consumers through closed ended questionnaire and analyzed through simple percentage analysis and SPSS to know about the relationship with different factors like, location, Quality, consumer satisfaction and preferences. Findings show that consumer’s choice is influenced by quality, price as well as location. Study also shows that McDonalds is a high quality restaurant according to the consumers perception and more expensive than any other MNC outlet in Pakistan, consumers prefer to visit KFC and McDonalds frequently the consumers in Pakistan prefer food with the price conscious attitude. The main thing for the fast food restaurants is the food which is served quickly and finds it more advantageous. According to this study location accessibility is also a motive for consumers when they choose a particular outlet, closer restaurants are more numerous for easy take away.
Production and Quality of Katuk (Sauropus androgynous (L.) Merr) Plants on Various Composition of Urea Fertilizer and Mexican Sunflower Compost
Authors: Rahayu Arifah , Rochman Nur , Nahraeni Wini
Published: January 2022

Daun katuk tidak hanya dimanfaatkan untuk sayuran tetapi juga sebagai bahan baku biofarmaka, sehingga perlu diproduksi secara ramah lingkungan, menggunakan pupuk organik. Penelitian ini bertujuan mengetahui pengaruh komposisi pupuk urea dan kompos kipahit terhadap produksi dan kualitas berbagai aksesi katuk.  Penelitian dilakukan dengan  rancangan acak lengkap faktorial. Faktor pertama yaitu sepuluh aksesi katuk (Sarampad, Maleber1, Maleber2, Kadudampit1, Kadudampit2, Gegerbitung, Dramaga, Cinangneng1, Cinangneng2, Katulampa). Faktor kedua adalah enam komposisi pupuk urea dan kompos kipahit, terdiri atas 100% N-urea, 100% N-kipahit, 75% N-urea+25% N-kipahit, 50% N-urea+50% N-kipahit, 25% N-urea+75% N-kipahit, dan tanpa pupuk N. Dosis pupuk N yang digunakan adalah 250 kg N ha-1.  Hasil penelitian menunjukkan katuk ‘Kadudampit1’ dan ‘Kadudampit2’ memiliki tinggi tanaman dan luas daun terbesar, ‘Sarampad’ dan ‘Maleber2’ menghasilkan jumlah tunas, panjang tunas total, bobot kering panen, dan kandungan klorofil total paling tinggi. Daun katuk ‘Katulampa’ memiliki kandungan padatan terlarut total (PTT) dan nitrat daun tertinggi. Pemberian berbagai kombinasi urea+kompos kipahit dapat menghasilkan jumlah tunas, panjang tunas total, bobot kering panen, kandungan klorofil total dan PTT setara dengan yang diberi urea, tetapi tinggi tanaman dan jumlah anak daun setara urea hanya terdapat pada tanaman yang diberi 50% N-urea+50% N-kipahit.  Penggunaan kompos kipahit dapat menurunkan kandungan nitrat daun dan mengurangi penggunaan urea.

Kata kunci: bobot kering panen, klorofil, nitrat, padatan terlarut total, Sauropus androgynous (L.) Merr
Needs Analysis: Development of Character-integrated Problem Solving Model for Chemistry Lessons in Senior High Schools
Authors: Mauliza Mauliza , Nurhafidhah Nurhafidhah , Hariadi Joko
Published: January 2022

Problem-solving learning models can not only improve cognitive and psychomotor aspects but also affective aspects. One of the affective aspects is character. This study aims to analyze the needs as a basis for developing a character-integrated problem-solving model in high school. This study uses a survey method. The research population is all Senior High School (SMA) and chemistry teachers in Langsa city. The research sample was determined by purposive sampling technique, obtained 4 Senior high schools, along with 7 chemistry teachers. Data were collected by using questionnaires, observation, and interview techniques. The type of questionnaire used is an open-closed questionnaire, consisting of 30 questions. The specific indicators used to reveal the need for developing a character-integrated problem solving are teacher readiness, teacher's need, student’s need, and Support. Data were analyzed descriptively. The results show that the development of a character-integrated problem-solving model for chemistry lessons in senior high school is very much needed. The findings of this study are in accordance with the findings of previous studies
Investigation of the Effect of Time to Ambulation on Patient Outcomes, Anxiety and Depression
Authors: BAYRAM AKKAYA Serap , KARACABAY Kevser
Published: January 2022

Purpose: The aim of the study was to investigation of the effects of time to ambulation on patient outcomes, anxiety and depression.

Method: This is a descriptive cross-sectional study. The study was conducted on 157 patients in the general surgery clinic of a training and research hospital in western Turkey. The data were collected using a Descriptive Form, Patient Outcomes Follow-up Form, Brief Pain Inventory, Hospital Anxiety and Depression Scale (HADS) and analysed by number, percentage, Mann–Whitney U test, Spearman correlation method using the Statistical Package for Social Science software version 24.

Results: The mean age of the patients who participated in the study was 49.5±18.1 years. The mean time to ambulation of the patients was 12.45±9.07 hours. The mean pain level of the participants in the last 24 hours, mean HADS-anxiety score and mean HADS-depression score were 3.7±1.7, 4.0±2.6 and 4.4±3.0, respectively.

Conclusions: In our study, we found that the time to ambulation was increased as the patients' age, duration of anaesthesia and depression scores increased. Additionally, the ambulation of patients with drains and catheters delayed. Furthermore, it was found that the duration of hospitalisation increased with the increase in the time to ambulation of patients.
Activity of Chirinkotan and Sarychev Peak volcanoes in 2021 (Kuril Islands)
Authors:   Institute of Marine Geology and Geophysics, Far Eastern Branch, Russian Academy of Sciences, Degterev A.V. , Chibisova M.V. , Zharkov R.V. ,   Institute of Marine Geology and Geophysics, Far Eastern Branch, Russian Academy of Sciences
Published: January 2022

This communication, based on satellite data and the results of visual observations, considers the main features of the activity of Chirinkotan and Sarychev Peak volcanoes in 2021. In the period from August 8 to 23, 2021, a moderate explosive eruption of Chirinkotan volcano took place. During this time, 11 volcanic explosions were recorded at an altitude of 1.5 to 4.5 km a.s.l. The parameters of the 2021 eruption were similar to previous eruptions in 2013–2015, 2016, 2017. At Sarychev Peak volcano on June 29, July 1, August 6 and November 26 of 2021 single relatively weak ejections to an altitude of about 2.2–3 km a.s.l. were recorded. Current activity of the volcano is associated with a recent effusive eruption that has taken place from December 2020 to February 2021, in which result a crater and mouth of the volcano turned out to be sealed with lava.
Deterministic and stochastic oscillations of fractal type during cooling of the melt
Authors:   The Donetsk Institute for Physics and Engineering named after O.O. Galkin of the National Academy of Sciences of Ukraine, Krasnyuk I.B. , Zabolotin A.E. ,   Institute of Marine Geology and Geophysics, Far Eastern Branch, Russian Academy of Sciences
Published: January 2022

A "single-phase" model of melt crystallization in the Penrose–Fife representation for temperature distributions under non-isothermal conditions is considered. The boundary conditions are assumed to be nonlinear and dynamic, i.e. they characterize the relaxation rate of the surface order parameter. In this case, the boundary conditions depend on the frequency of new phase nucleation and the rate of a melt crystallization in the (near-)surface layers of the mold. A method is proposed for predicting the appearance of ordered spatiotemporal (quasi-)crystalline structures of the fractal type of the crystalline phase in a liquid melt. The surface order parameter determines the mechanical and deformation properties of the sample depending on the temperature of the solid.
Market Responses Around the Publication Dates of Annual Financial Report
Authors:   Maranatha Christian University, Indonesia, Julyana Julyana , Njotoprajitno Rosemarie Sutjiati , Hadianto Bram
Published: January 2022

This research intends to investigate the market efficiency in the semi-strong shape by examining the response from the market participation around the annual financial report publication dates as the event. Moreover, to attain this intention, this study uses thirty-three consumer goods companies in the Indonesian capital market between 2018 and 2020 as samples. We use the Slovin formula and simple random sampling technique separately to count and take them. Furthermore, we check the proposed hypothesis by a one-sample t-test for each response from the market during the event period, i.e., twenty-one days. Based on the examination of market reaction, we infer that this reaction happens before, on, and after the publication date of the financial report. In other words, this circumstance supports the inefficient market in this shape.
DOMESTIC EPISTEMOLOGY AS A NEW STAGE IN DEVELOPMENT OF PHILOSOPHY OF KNOWLEDGE
Authors:   Moscow Pedagogical State University., Mikeshina L.A.
Published: January 2022

The article substantiates and illustrates that epistemology, the doctrine of social and humanitarian knowledge and subject, which is less abstract than gnoseology, was created both in Europe and in Russia, starting from the late 19th - early 20th centuries. This is confirmed by research on the specific ideas and works of E. Cassirer, C. Mannheim, and also P.L. Lavrov, N.K. Mikhailovsky, S.N. Bulgakov, S.L. Frank.
TRAINING OF FUTURE INTERPRETERS FROM JAPANESE IN RELATION TO THE NEW VECTOR OF INTERNATIONAL COOPERATION BETWEEN RUSSIA AND JAPAN
Authors:   Pacific State University (Khabarovsk)., Krivosheeva Е.I.
Published: January 2022

The note gives an overview of the potential employment areas for future graduates with the knowledge of Japanese language in relation to the recently upgraded relationship between Russia and Japan. Taking into account the emerging prospects for cooperation in the Far East of Russia, it is important to create new education programs in collaboration with potential employers to assist students with professional skills development in order to be able to fit future employer requirements.
Những 'bản nhạc đầu tiên' với thống kê Bayesian
Authors: Huyen Nguyen Thanh Thanh
Published: January 2022

Phương pháp nghiên cứu là cột sống của toàn bộ nghiên cứu, là con đường dẫn tới lời giải cho câu hỏi mà nhà nghiên cứu đặt ra. Vậy nên, đối với các nhà nghiên cứu trẻ, tìm hiểu và củng cố kiến thức về các phương pháp nghiên cứu là một phần trọng yếu để trưởng thành trong nghề.
Peran Media Promosi Kesehatan Terhadap Upaya Pencegahan Covid-19
Authors: pratama vivin widya wahyu
Published: January 2022

Media promosi kesehatan yang semakin berkembang memiliki nilai positif dalam memberikan informasi pada kondisi pademi Covid-19 saat ini. Peran media ini adalah media yang digunakan oleh mahasiwa secara berkelanjutan dalam menunjang perilaku pencegahan terutama pada individu. Jenis Penelitian kuantitatif dengan pendekatan cross sectional. Teknik uji statistik dengan dengan uji Spearman. Hasil analisis menunjukan peran media terhadap upaya pencegahan terhadap Covid-19 pada mahasiwa keperawatan memiliki hubungan dengan nilai p value 000> 0,05. Efek media promosi kesehatan terutama media sosial memiliki peran dalam pencegahan secara berkelanjutan