bluuebunny/crossref_metadata_2025 huggingface dataset:
Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018
Authors: Boulanger JM , Lindsay MP , Gubitz G , Smith EE , Stotts G , Foley N , Bhogal S , Boyle K , Braun L , Goddard T , Heran MKS , Kanya-Forster N , Lang E , Lavoie P , McClelland M , O’Kelly C , Pageau P , Pettersen J , Purvis H , Shamy M , Tampieri D , vanAdel B , Verbeek R , Blacquiere D , Casaubon L , Ferguson D , Hegedus Y , Jacquin GJ , Kelly M , Kamal N , Linkewich B , Lum C , Mann B , Milot G , Newcommon N , Poirier P , Simpkin W , Snieder E , Trivedi A , Whelan R , Eustace M , Smitko E , Butcher K
Published: July 2018

The 2018 update of the Canadian Stroke Best Practice Recommendations for Acute Stroke Management, 6th edition, is a comprehensive summary of current evidence-based recommendations, appropriate for use by healthcare providers and system planners caring for persons with very recent symptoms of acute stroke or transient ischemic attack. The recommendations are intended for use by a interdisciplinary team of clinicians across a wide range of settings and highlight key elements involved in prehospital and Emergency Department care, acute treatments for ischemic stroke, and acute inpatient care. The most notable changes included in this 6th edition are the renaming of the module and its integration of the formerly separate modules on prehospital and emergency care and acute inpatient stroke care. The new module, Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care is now a single, comprehensive module addressing the most important aspects of acute stroke care delivery. Other notable changes include the removal of two sections related to the emergency management of intracerebral hemorrhage and subarachnoid hemorrhage. These topics are covered in a new, dedicated module, to be released later this year. The most significant recommendation updates are for neuroimaging; the extension of the time window for endovascular thrombectomy treatment out to 24 h; considerations for treating a highly selected group of people with stroke of unknown time of onset; and recommendations for dual antiplatelet therapy for a limited duration after acute minor ischemic stroke and transient ischemic attack. This module also emphasizes the need for increased public and healthcare provider’s recognition of the signs of stroke and immediate actions to take; the important expanding role of paramedics and all emergency medical services personnel; arriving at a stroke-enabled Emergency Department without delay; and launching local healthcare institution code stroke protocols. Revisions have also been made to the recommendations for the triage and assessment of risk of recurrent stroke after transient ischemic attack/minor stroke and suggested urgency levels for investigations and initiation of management strategies. The goal of this updated guideline is to optimize stroke care across Canada, by reducing practice variations and reducing the gap between current knowledge and clinical practice.
Stroke admission outside daytime working hours delays mechanical thrombectomy and worsens short-term outcome
Authors: Hoepner Robert , Weber Ralph , Reimann Gernot , Berger Klaus , Kitzrow Martin , Fischer Sebastian , Weimar Christian , Eyding Jens , Krogias Christos
Published: July 2018

Background and purpose

Rapid therapeutic decisions in acute stroke patients leading to earlier initiation of revascularization therapies are associated with better outcome. An association between regular working hours and reduced time to initiation of intravenous thrombolysis has been reported. However, its influence on mechanical thrombectomy (MT) remains uncertain. We aimed to analyze the effects of admission time on door-to-groin time and stroke outcome in a large prospective stroke registry of the Neurovascular Net Ruhr in Germany.

Methods

Procedural times of a total of 512 patients treated with MT were analyzed. Admission to hospital during regular working days and hours (Monday to Friday, 8 am to 4 pm) was compared with admission outside these times. Door-to-groin time and the difference in NIH Stroke Scale between admission and discharge served as primary outcome parameters. Long-term functional outcome was centrally assessed with modified Rankin scale.

Results

MT outside regular working hours was associated with a significant mean initiation delay of 20 min. By multivariate regression analysis, every 20 min delay of MT reduced the difference in NIHSS score between admission and discharge by 0.76 points (95% CI −1.24 to −0.28, p = 0.002). Favorable long-term outcome did not differ between both treatment groups.

Conclusions

Treatment outside regular working hours caused a significant delay in the initiation of MT, which was associated with a decreased short-term clinical efficacy of thrombectomy. Strategies like compulsory attendance of the interventional neuroradiologist at the hospital 24/7 might result in shorter door-to-groin times and consecutive in better stroke outcome.
Nursing Period, Behavior Development, and Growth Pattern of a Newborn Formosan Pangolin (Manis pentadactyla pentadactyla) in the Wild
Authors: Sun Nick Ching-Min , Sompud Jephte , Pei Kurtis Jai-Chyi
Published: July 2018

The Formosan pangolin mainly inhabits the lowland forest in Taiwan. Biological information on pangolins is limited due to their solitary behavior. This study reports the first field record of the behavior development and growth pattern of a newborn male Formosan pangolin during the entire nursing period in the wild. The methods used in this study were radio-tagging and camera-trapping. Data collection for this study was conducted from November 2014 until May 2015. The nursing period was 157 days. The infant started to exit the nursing burrow alone at 11 weeks old, with significant soil scraping and licking behaviors. The duration and distance of the exploring were both extended considerably after 15 weeks old. All exploring behaviors that were recorded occurred after the mother had left the burrow. The total body length of the infant pangolin growth was at a relative constant rate of 1.2 cm/week during the nursing period, which was faster than the only record from a hand-reared individual (0.7 cm/week). This study presents a useful method to monitor the maternal behaviors and infant growth pattern for the Formosan pangolin under natural conditions.
Constructing the Platform-Specific Self-Brand: The Labor of Social Media Promotion
Authors: Scolere Leah , Pruchniewska Urszula , Duffy Brooke Erin
Published: July 2018

With the widespread uptake of social media, discourses and practices of self-branding have become a pervasive feature of social and economic life. However, the way in which the digital self-brand gets reproduced across a sprawling social media landscape remains comparatively under-theorized. Our paper therefore draws upon in-depth interviews with 52 online content creators—including designers, artists, writers, and marketing consultants—to examine how cultural workers present themselves across the panoply of social networking sites. As we show, workers’ self-presentation activities were structured through the production of a platform-specific self-brand, which was based upon the imaginations of (1) platform affordances, (2) audiences, and (3) the producer’s own self-concept. Our findings highlight producers’ compulsion to engage in continuous, cross-platform labor—despite widespread uncertainty about its economic outcomes. We conclude by addressing the stakes of a social media moment when workers of all stripes are prodded to incessantly curate, monitor, and ultimately invest in their online personae.
Cultivando La Voz Mujer: Latina Adolescent Girls and Their Mothers Rewriting Their Pasts and Imagining Their Futures
Authors: Flores Tracey T.
Published: July 2018

This article shares the experiences of Latina adolescent girls (Grades 7–12) and their mothers as participants in Somos Escritoras/We are Writers, a creative writing workshop that invites girls and their mothers to engage in the sharing of stories through art and writing. In the creation of Somos Escritoras, I position Black and Chicana feminist thought as important experiential knowledge to center that of my participants’ experiences as valuable points to begin theorizing. In addition, I weave Gutiérrez’s conceptualization of third space and Anzaldúa’s theorizing of Nepantla to describe the spaces of liminality the girls and mothers navigate and the potential of Somos Escritoras as a site of transformation. Drawing upon field notes, writing, artwork, and interviews, I share how girls and their mothers used writing and artwork to express themselves, define themselves, and learn from one another through their collective sharing of stories and experiences. Somos Escritoras is an example of a family engagement space that centers the cultural and gendered ways of knowing and being of Latina girls and women as important sites of knowledge to cultivate similar spaces with and for families.
Scaffolding Reading Comprehension for Competent Readers
Authors: Hattan Courtney , Alexander Patricia
Published: July 2018

Scaffolding has been shown to facilitate students’ text comprehension and task performance. Yet less is known about the necessity of scaffolding for competent students reading unfamiliar content. To explore that question, we investigated the effects of two knowledge scaffolding techniques (i.e., mobilization and concept mapping) versus control on undergraduates’ comprehension overall and by question type. The 118 undergraduates were randomly assigned to a condition and read a text about cellular biology. Results indicated a significant effect of scaffolding on students’ comprehension after controlling for prior knowledge. Follow-up analyses for overall comprehension demonstrated that the concept mapping group outperformed the mobilization and control groups, and the mobilization group outperformed the control group. These results suggest that competent readers benefit from scaffolding when reading unfamiliar content.
Aspirin Resistance and Stroke
Authors: Sisodia Pranjal , Bhatia Rohit
Published: July 2018

Stroke is a leading cause of death and disability worldwide. Aspirin is the most commonly used antiplatelet drug in both primary and secondary prevention of cerebrovascular and cardiovascular diseases. A proportion of patients may have stroke recurrence while they are on treatment with aspirin, giving rise to term aspirin resistance or aspirin failure. Studies have suggested that such recurrence could partly be attributed to biochemical aspirin resistance, with an estimated prevalence ranging between 5% and 65% among patients with ischemic stroke in the published studies. Common methods to evaluate laboratory aspirin resistance include light transmission aggregometry, PFA-100, VerifyNow-Aspirin assay, serum thromboxane B2, and urinary 11-dehydrothromboxane B2. Aspirin resistance is multifactorial in origin and involves diverse environmental and genetic factors, including single-nucleotide polymorphisms, miRNAs, drug interactions, and co-morbid risk factors. The current review overviews the concept of aspirin resistance, its evaluation and relationship with stroke recurrence, its outcome, and its implications on stroke management in the future.
Platelets kill circulating parasites of all major Plasmodium species in human malaria
Authors: Kho Steven , Barber Bridget E. , Johar Edison , Andries Benediktus , Poespoprodjo Jeanne R. , Kenangalem Enny , Piera Kim A. , Ehmann Anna , Price Ric N. , William Timothy , Woodberry Tonia , Foote Simon , Minigo Gabriela , Yeo Tsin W. , Grigg Matthew J. , Anstey Nicholas M. , McMorran Brendan J.
Published: July 2018

Key Points

Platelets directly interact with and kill circulating Plasmodium parasites in patients with malaria to help control parasitemia. In vitro platelet antiplasmodicidal activity against P knowlesi involves platelet–cell binding and intracellular accumulation of PF4.
Empirical Linear Seismic Site Amplification in Central and Eastern North America
Authors: Parker Grace A. , Stewart Jonathan P. , Hashash Youssef M. A. , Rathje Ellen M. , Campbell Kenneth W. , Silva Walter J.
Published: July 2018

We present empirical linear site amplification models conditioned on time-averaged shear wave velocity in the upper 30 m ( VS30) for central and eastern North America. The models are derived from ground motion data and site condition information from the NGA-East project and are intended for use with reference rock ground motion models. Site amplification is found to scale with VS30 for intermediate to stiff site conditions ( VS30 > 300 m/s) in a weaker manner than for active tectonic regions such as the western United States. For stiff sites ( >800 m/s), we find differences in site amplification for previously glaciated and nonglaciated regions, with nonglaciated sites having lower amplification. The models were developed using a combination of least-squares, mixed effects, and Bayesian techniques; the latter show that accounting for predictor uncertainty does not appreciably affect the median model but decreases model dispersion. Our VS30-scaling models are modular and additive to simulation-based models for the nonlinear components of site response. A limitation of the present models is that they do not account for site-specific resonance effects.
Viscoelastic Coupling Dampers for Enhanced Multiple Seismic Hazard Level Performance of High-Rise Buildings
Authors: MacKay-Lyons Renée , Christopoulos Constantin , Montgomery Michael
Published: July 2018

Viscoelastic coupling dampers (VCDs) are installed in lieu of traditional reinforced concrete (RC) coupling beams in high-rise buildings to provide distributed supplemental damping for all dynamic loading conditions without affecting the architectural layout. When distributed effectively over the height of the building, VCDs provide viscous damping in all lateral modes of vibration and an elastic restoring force that enhances the lateral stiffness of the coupled system. In this paper, a first extensive numerical case study is carried out to compare the seismic performance of a conventional coupled shear wall high-rise building to a high damping alternate of the same design in which VCDs replace all diagonal RC beams in the core to enhance its seismic resilience. The added damping from VCDs is intended to reduce the peak responses under low amplitude earthquakes, but for larger amplitude maximum credible earthquakes, the peak responses are similar; however, structural damage is greatly reduced. Three seismic hazard levels were investigated, and the results indicate that the use of VCDs reduces peak floor accelerations, story drifts, and story shears over all seismic intensities. Nonlinear time-history analysis results also highlighted the improved resilience of the VCD structure at the maximum credible seismic hazard level where the use of VCDs eliminated all damage to coupling beams that would otherwise require repair over most of the height of the building.
Hypercalcemia in Glucagon Cell Hyperplasia and Neoplasia (Mahvash Syndrome): A New Association
Authors: Gild Matti L , Tsang Venessa , Samra Jaswinder , Clifton-Bligh Roderick J , Tacon Lyndal , Gill Anthony J
Published: July 2018

Context

Hyperglucagonemia in the absence of glucagonomas is rare. Biallelic-inactivating mutations in the glucagon receptor gene (GCGR) cause glucagon cell hyperplasia and neoplasia (GCHN), also termed Mahvash syndrome. Here, we report the first case to our knowledge of GCHN presenting with hypercalcemia and demonstrate a unique relationship between calcium and α-cell hyperplasia.

Case Description

A 47-year-old man presented with severe PTH-independent hypercalcemia, 13.95 mg/dL (3.48 mmol/L). Imaging and extensive pathology tests yielded no conclusive cause. Glucagon levels >300 times the upper limit of normal were discovered. Subtotal pancreatectomy identified α-cell hyperplasia and neoplasia with metastatic disease in lymph nodes. Genomic analysis confirmed a homozygous missense variant in GCGR (Asp63Asn). This is a previously described pathologic variant and has a known association with GCHN.

Conclusions

Inactivating mutations of the glucagon receptor gene lead to nonfunctional hyperglucagonemia and are associated with GCHN. Homozygous or compound heterozygous GCGR mutations are associated with α-cell hyperplasia, a known precursor to pancreatic neuroendocrine tumors that can metastasize. Hypercalcemia is an unreported consequence of GCHN with an unclear mechanism.
Funding global health product R&D: the Portfolio-To-Impact Model (P2I), a new tool for modelling the impact of different research portfolios
Authors: Terry Robert F , Yamey Gavin , Miyazaki-Krause Ryoko , Gunn Alexander , Reeder John C.
Published: July 2018

Background: The Portfolio-To-Impact (P2I) Model is a novel tool, developed to estimate minimum funding needs to accelerate health product development from late stage preclinical study to phase III clinical trials, and to visualize potential product launches over time.

Methods: A mixed methods approach was used. Assumptions on development costs at each phase were based on clinical trial costs from Parexel’s R&D cost sourcebook. These were further refined and validated by interviews, with a wide variety of stakeholders from Product Development Partnerships, biopharmaceutical and diagnostic companies, and major funders of global health R&D.

Results: the tool was used to create scenarios describing the impact, in terms of products developed, of different product portfolios with funding ranging from $1 million per annum through to $500 million per annum. These scenarios for a new global financing mechanism have been previously presented in a report setting out the potential for a new fund for research and development which would assist in accelerating product development for the diseases of poverty. 

Conclusion: The P2I tool does enable a user to model different scenarios in terms of cost and number of health products launched when applied to a portfolio of health products.  The model is published as open access accompanied with a user guide.  The design allows it to be adapted and used for other health R&D portfolio analysis as described in an accompanying publication focussing on the pipeline for neglected diseases in 2017. We aim to continually refine and improve the model and we ask users to provide us with their own inputs that can help us update key parameters and assumptions.  We hope to catalyse users to adapt the model in ways that can increase its value, accuracy, and applications.
The overlap between miscarriage and extreme preterm birth in a limited-resource setting on the Thailand-Myanmar border: a population cohort study
Authors: McGready Rose , Paw Moo Kho , Wiladphaingern Jacher , Min Aung Myat , Carrara Verena I. , Moore Kerryn A. , Pukrittayakamee Sasithon , Nosten François H.
Published: July 2018

Background: Countries vary on the demarcation gestational age that distinguishes miscarriage and extreme preterm birth (PTB). This study provides a synopsis of the outcome of pregnancy between 22 to <28 weeks’ gestation from a low resource setting.

Methods: A retrospective record review of a refugee and migrant population on the Thailand-Myanmar border with outcome between 22 to <28 weeks’ gestation, was conducted. Outcomes were classified as miscarriage: non-viability prior to 22 week’s gestation with expulsion of products between 22 to < 28 weeks’ gestation; or extreme PTB when the fetus was viable at ≥22 weeks and delivered between 22 to < 28 weeks’ gestation. Termination of pregnancy and gestational trophoblastic disease were excluded.

Results: From 1995-2015, outcomes occurred between 22 to <28 weeks’ gestation in 0.9% (472/49,931) of pregnancies and 3.8% (18/472) met the exclusion criteria. Most included pregnancies (n=454) had ultrasound done 72.5% (n=329). Overall 43.6% (n=197) were miscarriage and 56.4% (n=257) extreme PTB. Miscarriage (late expulsion) between 22 to <28 weeks was observed with non-viability occurring at an estimated median gestation of 16 weeks. For cases with available data (n=252, 5 missing) the proportion of stillborn was 47.6% (n=120), liveborn 52.4% (n=132); and congenital abnormality 10.5% (24/228, 29 missing). Neonatal death was high 98.5% (128/131, 1 missing). Introduction of ultrasound was associated with a 2-times higher odds of classification of outcome as birth rather than miscarriage.

Conclusion: In this low resource setting <1% of pregnancy outcomes occur in the 22 to <28 weeks’ gestation window; nearly half  were miscarriage; and neonatal mortality approached 100%.  In the scale-up to preventable newborns deaths, at least initially, greater benefits will be obtained by focusing on the greater number of viable newborns with a gestation of 28 weeks or more.
The Relevance of Competencies of Graduates of Engineering Professions in the Labour Market
Authors: Сигат Е. , Sigat E. , Полянок О. , Polyanok O.
Published: July 2018

The article is devoted to the study of the relevance of the competencies of graduates of engineering specialties in the labour market. The authors consider higher schools of Russia and America. Schools are guided in training of engineers on deep and actual knowledge, skills in the professional sphere, but forget about not less important, fl exible (soft) skills which are accepted to call «soft skills». The authors consider the quality of education of students in connection with its competitiveness and the possibility of employment in the labour market, the relationship between education and employment, the relationship of assessments and the actual competencies of the specialist. The authors show that the key indicators of the eff ectiveness of higher education and the quality of training is the degree of orientation of educational programs on the labour market. Labour market orientation is realized through interaction between education and employers and is formalized in the form of criteria and requirements for graduates in terms of their current practical suitability for employment. The introduction of new Federal educational standards poses the problem of developing such curricula, the implementation of which will allow graduates to form the necessary competence for employers. This suggests the need to introduce an additional system of assessing the qualifi cations of young professionals in the educational process of higher education, helping to determine the degree of their readiness to work in the profession and the initial orientation of University curricula to maximize this readiness. The system of professional standards acts as a basis, which helps to build training in accordance with the production requirements and determine the quality of this training.
Master’s Role Features in Modern Production
Authors: Шаталова Н. , Shatalova Nina
Published: July 2018

Challenges and contradictions of the master’s status in production are shown based on author’s sociological research and synthesis of expert assessment. The status of the master nowadays is marginal in many enterprises: the number and content of duties does not correspond to the rights that are written in the job instruction. Frequently the master has to perform additional duties. This creates problems in the work of masters, the team and often in the whole production process. The necessity and examples of continuous search for the most expedient ratio of rights and duties on the three steps of the managerial ladder is demonstrated.
Biblical Interpretation and Analytic Reflection
Authors: Sarisky Darren
Published: July 2018

Analytic skill can contribute to a theology of the Bible and a theological hermeneutic in two ways, by refining the formulation of a doctrine of Scripture and a correlative hermeneutic, and by illuminating how problematic hermeneutical presuppositions have in some cases become part of exegetical practice.  The contribution that the analytic style of reflection can make to the theological enterprise need not be vitiated by a common criticism of analytic modes of engaging with texts, namely, that they tend toward being ahistorical, though the objection deserves to be considered carefully.
Of Generic Gods and Generic Men: The Limits of Armchair Philosophy of Religion
Authors: McGrew Lydia
Published: July 2018

Thomas Crisp has attempted to revive something akin to Alvin Plantinga’s Principle of Dwindling Probabilities to argue that the historical case for the resurrection of Jesus does not make the posterior probability of the resurrection very high. I argue that Crisp’s argument fails because he is attempting to evaluate a concrete argument in an a priori manner. I show that the same moves he uses would be absurd in other contexts, as applied both to our acquaintance with human beings and to evidence for divine intervention. Crisp’s attempt to relate the evidence for a specific act of God such as the resurrection to generic theism, thereby creating skepticism about the power of the evidence, is symptomatic of a larger problem in the philosophy of religion which I dub “separationism” and which has characterized the work of both advocates of classical apologetics and philosophers of science.
The Sanctifying Work of the Holy Spirit: Revisiting Alston’s Interpersonal Model
Authors: Porter Steven L , Rickabaugh Brandon
Published: July 2018

Of the various loci of systematic theology that call for sustained philosophical investigation, the doctrine of sanctification stands out as a prime candidate.  In response to that call, William Alston developed three models of the sanctifying work of the Holy Spirit: the fiat model, the interpersonal model, and the sharing model.  In response to Alston’s argument for the sharing model, this paper offers grounds for a reconsideration of the interpersonal model.  We close with a discussion of some of the implications of one’s understanding of the transforming work of the Holy Spirit for practical Christian spirituality.
Reflections From Co-Researchers With Intellectual Disability: Benefits to Inclusion in a Research Study Team
Authors: St. John Brittany , Mihaila Iulia , Dorrance Katelyn , DaWalt Leann Smith , Ausderau Karla K.
Published: July 2018

Participatory action research methodologies may empower and protect marginalized individuals; however, they remain underutilized. Limited studies have investigated the impact of participatory action research, specifically on individuals with intellectual disability (ID). This study examines (1) the perspectives of co-researchers with ID on their involvement in the research process and (2) the feasibility of their inclusion based on perspectives of research staff (academic faculty and graduate students without ID). Three co-researchers with ID were interviewed regarding their research participation. Thematic analysis of interviews identified four themes: (1) Shared Experience of Disability, (2) Teaching and Guidance, (3) Acquisition of Skills and Knowledge, and (4) Value of Participation. Research staff reviewed field notes and identified benefits and challenges to feasibility of including co-researchers with ID. Inclusion of co-researchers with ID was found to be both meaningful and feasible.
PROPOSAL FOR SECURING A ROCK MASSIF NEAR BEROUN RAILWAY STATION
Authors: Barták Jiří
Published: July 2018

The proposal concerns the securing of a 100 m long section of the rock slope along the lead track at Beroun railway station, where a relatively massive rock block collapsed in June 2016. The rock slope is about 30 m high and its character is mainly determined by the orientation of several discontinuity systems. It was proposed for the most dangerous discontinuities that monitoring elements be used for measuring deformations at least for half a year. Dynamic barriers and protective fences were proposed for the most endangered parts of the slope.
Uso del suelo y estructura de la vegetación en paisajes fragmentados en la Amazonia, Colombia
Authors: Meza Elizalde María Constanza , Armenteras Pascual Dolors
Published: July 2018

El seguimiento al uso del suelo y el conocimiento del estado de la vegetación en remanentes de bosques de paisajes representan una metodología fundamental para la planificación del territorio ante la acelerada fragmentación. Por ello, se realizó un análisis multitemporal de la composición y configuración del paisaje (1990-2016) y se establecieron transectos de muestreo de la vegetación. Se identificó una pérdida del 56.34% de áreas de bosque, aumento en el número de parches, reducción de su área y ampliación de la distancia entre relictos, lo que evidencia procesos activos de fragmentación. En los bosques muestreados se registró la dominancia de especies heliófitas generalistas de ecosistemas perturbados y se encontró una reducción en la complejidad estructural asociada a una baja densidad de individuos (DAP≥ 10 cm) en el estrato superior arbóreo, mostrando que la fragmentación del paisaje ha conllevado a la degradación de estos bosques.
Las representaciones sociales, un concepto a tener en cuenta
Authors: Gallego-Torres Adriana Patricia
Published: July 2018

Editorial
Arti Penting Ruang Hijau Kota bagi Masyarakat dan Pemerintah Kota (Ruang Hijau Kota di Lyon, Prancis)
Authors: Fitriandana Bima , Wittner Laurette , Syahbana Joesron Alie
Published: July 2018

The appearance of different urban green space phenomena occuring both in developing and developed countries appeals to be found out in research. Urban green space hasn’t been an essential element in developing countries, such as in Indonesia and its big city. In another part, precisely in Lyon, urban green space is considered as an intergral and important part of city development, particularly in last 24 years (begun in 1990’s). Moreover, their people actively participate in some urban green space projects and go frequently in urban green spaces or urban parks. By indentifying those two phenomena, it’s vividly seen a problem both in societal and municipal level. Based on those facts, this research tried to find out a research question which is about the importance of urban green space for society and minicipality. This research that has been conducted in Tête d’Or park, gerland park, Sergent Blandan park, the river bank of Saône and Rhône as well as Mazagran park, used qualitative methode with some interviews reserved to some key actors, including society. The result shows that society regards urban green space as a source of benefit for social, education and health. Whereas, municipality considers it as an integral element of city providing environmental and economic benefit for city.
Kajian Strategi Pengembangan Zona Air Minum Prima (Zamp) pada Kelompok Pelanggan Rumah Tangga di Kota Bogor (Studi Kasus: Eksisting Zamp di Kecamatan Bogor Selatan dan Bogor Timur)
Authors: Gumilar Nurul Ainy
Published: July 2018

PDAM Tirta Pakuan as the operator of water supply in Bogor city is very attentive to provide good drinking water services to the public, especially the distribution of potable water quality through a network of piping in some areas called Zona Air Minum Prima (ZAMP). The program has been ongoing since 2004, but until now the coverage is still low compared with the total customer taps in Bogor City. Under these conditions, a research that aims to formulate development strategies in Zona Air Minum Prima (ZAMP) for groups of households customer in Bogor City is conducted. Based on the results of the survey on medium (R3-R5) and the upper middle (R6-R8) households customer in the existing ZAMP and development plans ZAMP area in Taman Yasmin, there are similar characteristics to customers in both regions indicate development potential. Assessment of customer satisfaction on aspects of quality, quantity and continuity of water in the region showed a "good" score, but an assessment of the communication aspect of PDAM is not good, especially in terms of information provided by PDAM are judged less by the customer. Based on research conducted there can be formulated several strategies, such as communication strategy through early and advanced socialization, price or tariff adjustment strategy of potable water and an additional water filter installation strategy.
The Influences of Migrant Settlement To The Local Community: An Analysis of Socio - Economic Aspect (Case of Ampenan and Sekarbela, Mataram Municipality)
Authors: Pratama Reba Anindyajati
Published: July 2018

Many cities in Indonesia are experiencing the high level of migration as the symptom urbanization process. In the other hand, the presence of the migrant in the urban area will bring changes to the local environment. As the case, Central Statistical Bureau reported Mataram has experienced 31% of recent migration in the province or recorded 36.326 new migrant during 2007-2012. Furthermore, Ampenan as one of the main sub district has been split into Sekarbela to accommodate the pressure of urban demand. This research aims to eradicate the existence of migrant and its influences in Ampenan and Sekarbela from socio-economic aspects. Specific objectives of the research are; eradicating the interaction between migrant and the place, and analyzing the influences of migrant settlement to the local community. This research finds there are different patterns on how lower and upper-middle migrant resided and contributed to the area of Ampenan and Sekarbela. The lower-middle migrant tend to have more influence to the informal sector and social relationship in the old town of Ampenan. The upper-middle migrant tend to have more influence in socio-economic transformation of the local people in Sekarbela due to the need of the new development.
Pengembangan Infrastruktur Pelabuhan Panjang Sebagai Pelabuhan Cargo Bertaraf Internasional
Authors: Rachmadi Adi
Published: July 2018

Infrastructure development in Indonesia continued to show progress, including the development of the port as a place which is an integrated system consisting of transport in the waters, port, safety and security, and environmental protection in maritime. Lampung province that has the port will control that is essential for the regions surrounding potential in improving the economy, especially industry and trade both nationally and internationally. The purpose of this study was to assess the Port of Panjang infrastructure development as an international cargo port. Therefore, researchers using the theory to fill positivistic approach and examples of best practice to fill rationalistic. Best practice is used is the Port of TanjungPriok, Jakarta, and Port of Busan, South Korea as a cornerstone of researchers to conduct research. The research character is a descriptive. Methods of data collection is done by direct observation to the test site and interview techniques combined with a list of questions to the government and service users. The results showed Port of Panjang Infrastructure meet the minimum requirements of international cargo ports established by the IMO, the Port of Panjang must add infrastructure and supporting facilities. Water facilities, ports should be developed, among others, relocation is docked tug boat, pilot boat and service boat, while the infrastructure to be developed is the yard, office building (banking) and postal telecommunications, reactivation of the railway to transport coal, and gangway to lane expressway passenger sea.
Efektivitas Kelembagaan Pemerintah Dalam Pengembangan KEK Tanjung Lesung Kabupaten Pandeglang Provinsi Banten
Authors: Meliana Katrina Doris , Buchori Imam
Published: July 2018

Special Economic Zone (SEZ) Tanjung Lesung located in Pandeglang, Banten Province, was established to increases local economy by tourism. Under law No. 39 year 2009 on SEZ, SEZ was managed by Zone’s board with assistance of SEZ secretariat, its administrator, and company such as PT. Banten West Java  (BWJ). Effective institutional productivity is needed in the development of SEZ Tanjung Lesung. This research uses quantitative and qualitative methods to measure effectivity level of its employee’s character, government policy, human resources effectivity, also role and coordination of zone’s board . There is inefficiency in SEZ management mainly in role and coordinating aspects that turns  SEZ working inefficently because of the lack of coordination, communication, service standards, monitoring and supervision. Further institutional evaluation and restructurization is needed to ensure optimum SEZ function.
Evaluasi Penerapan Kerjasama Pemerintah - Swasta Dalam Pembangunan dan Pengelolaan Pasar Desa Penyangkringan - Weleri - Kabupaten Kendal (Tinjauan Aspek Finansial dan Aspek Ekonomi)
Authors: Rahutama Ryan
Published: July 2018

Penyangkringan villages became one village into the Center for Environmental Activities (PKL) to the service center functions as a center of trade and services in accordance with the Spatial Kendal Year 2011-2031. The village where Penyangkringan have potential cash asset village that has not been optimally and can not accommodate these activities so that the village government plans to build a village market. But with a limited budget, cooperation with the private sector to be the solution to overcome it. Authorities village rural market development cooperation with built-operate-transfer (BGS) with a contract term of 10 years. Therefore we need a study evaluating the implementation of the cooperation that focus on the financial feasibility and economic aspects. The purpose of this study was to evaluate the implementation of village government and private partnership in the development of rural markets in financial aspects and economic aspects. Financial and economic aspects views of four criteria: Net Present Value (NPV), Internal Rate of Return (IRR), Benefit Cost Ratio (BCR), and Pay Back Period (PBP). The results showed that the financial results obtained Rp. 193.610.176 (NPV), 13,5 % (IRR), 1,035 (BCR), and 4 Years, 3 Months (PBP), while economically the results obtained Rp. 143.437.317 (NPV), 11,6 % (IRR), 1,01 (BCR) and 4 Years, 4 Months (PBP)
Kajian Aktivitas Pedagang Kaki Lima di Ruang Publik Kawasan Simpang Lima Pati
Authors: Taufik Muhamat
Published: July 2018

Street vendors in Pati Simpang Lima area are invading urban public spaces with increasing number. While providing job opportunities, their unregulated existence reduces the level of service of the public spaces and has starting to create environmental problems. The study examines the street vendors’ activity characteristics, space and infrastructure availability, seller and customer preference and the local government’s policy on street vendors. The study identified that the availability of open public space in Pati Simpang Lima area have attracted the increase of street vendor activities. There is a growing need for infrastructure such as parking spaces, public toilets and waste related infrastructure. There has not been any local government regulation let alone innovative approaches to street vendor activities in either socio‐cultural, economic nor normative terms. The direction was to physically regulate the street vendor area in terms of vendor space allocation, business times regulations and infrastructure. The lack of space in the area has imposed a need for relocation for some of the vendors to a new place such as Jalan Penjawi, with adequate supply of infrastructure. In terms of policy, there should be legalization and limitation of the number of street vendors using socio‐cultural, economic and normative models.
Kajian Perkembangan dan Lokasi Minimarket di Kawasan Tembalang
Authors: Marina Syahira , Setyono Jawoto Sih
Published: July 2018

Tembalang area, located in the outskirt of Semarang city is experiencing the proliferation of modern convenient shops (minimarkets) dominated be Indomaret and Alfamart shops. Since 2001, 13 (thirteen) minimarkets have been established along the Jalan Bulusan to Jalan Ngesrep Timur corridor with the highest growth during the 2004‐2009 period. Most of the shops have been established by constructing on an empty land or residing a redesigned existing building. Consumer behavior analysis revealed that 39,9% consumer visits happens twice a week with 62,7% of them to buy daily consumer products. Proximity has been identified as the highest motivation to shop in these minimarkets, followed by variability of products. Locational analysis identified overlapping of service range of the minimarkets due to close proximity between each other. The minimarkets located in the Jalan Ngesrep Timur – Jalan Prof. Sudarto corridor have the highest accessibility, while those located on Jalan Tirto Agung have the least. This study found oligopolistic competition among the two minimarkets.
Technology Enhanced Learning, Research Impact and Open Scholarship
Authors: Cochrane Thomas , Redmond Petrea , Corrin Linda
Published: July 2018

This guest editorial explores the potential impact of alternative metrics and social research networks to enhance Technology Enhanced Learning (TEL) research and practice, particularly in the realm of open scholarship. Conventional measures of research impact are based upon a publications’ impact factor. Article or author-level metrics can provide a better view of the contribution to the field of research of a specific research project. However, metrics are based upon citation counts that can take years to accumulate.  This can result in a significant lag between the original research, communicating research outcomes to the wider research community, and research impact. TEL researchers are in a unique position to spearhead the growing movement towards open social scholarship and alternative metrics. Alternative metrics provide a powerful addition to conventional measures of research impact, facilitating a dynamic conversation around TEL research. Social media conversations provide the foundation for a collaborative open Scholarship of Technology Enhanced Learning as both an enhancement and alternative to conventional modes of research impact measurement. This guest editorial outlines key tools that are currently used to measure impact. We argue that a culture of open scholarship enhanced via social media and measured via alternative metrics creates an effective feedback loop between research and practice.
Comparison Between Whole-Body MRI and PET/CT in Pediatric Oncology
Authors: Trofimovica Anastasija , Apine Ilze
Published: July 2018

Introduction. Positron emission tomography/computer tomography (PET/CT) is one of the main imaging tests for solid tumor and metastases diagnostic nowadays. However, PET/CT scanning is related to the risk of ionizing radiation exposure, which is especially harmful for children health. Whole-body MRI (WB-MRI) allows exact evaluation of malignant tumor without the radiation exposure.

Aim of the Study.To compare and evaluate informativity of WB-MRI and PET/CT imaging methods for detection of metastases in children with malignant disease, being treated at Children’s Clinical University Hospital, Riga, Latvia. The gained data were also compared to the world data published before.

Material and methods. This retrospective study included all patients in whom both PET/CT and WB-MRI imaging examinations were performed between July 2016 and February 2017 in Latvia. Inclusion criteria were: age under 18 years, histological confirmation of a malignant disease. The study included 10 patients (7 males, 3 females, mean age 11 years 7 months). Two patients underwent both examinations 3 times, resulting in a total of 14 cases.

Results. There were identified three types of tumor: Hodgkin lymphoma (n = 12), non-Hodgkin lymphoma (n = 1), rhabdomyosarcoma (n = 1).

PET/CT mean radiation exposure was 263,2 [95% CI: 202.27 - 324.12] mGy.cm, mean radiotracer dosage was 143,5 [95% CI: 114. - 172.52] MBq.

There were identified 34 lesions: 24 (70%) lymph nodes, 5 (15%) bone lesions, 5 (15%) soft tissue lesions. 21 malignant lesions were detected by PET/CT. 27 lesions were found by WB-MRI. Out of 34 lesions, eighteen were identified by both imaging methods. Both examinations found absence of residual disease in 2 cases.

Eleven lesions were detected by WB-MRI (7 lymph nodes, 1 bone lesion and 3 soft tissue lesions) that were not identified by PET/ CT. 5 lesions could not be identified by WB-MRI (2 lymph nodes, 1 bone lesion and 2 soft tissue lesions) that were detected by PET/CT imaging method.

Conclusions. WB-MRI examination should be used before and in addition to PET/CT imagining in children with oncological disease. PET/CT examination results interpretation should be done based on WB-MRI imaging results. WB-MRI could not completely replace PET/CT imaging.
The Role of Taylor Spatial Frame in the Treatment of Blount Disease
Authors: Tsibidakis Haridimos , Panou Artemisia , Angoules Antonios , Sakellariou Vassilios I. , Portinaro Nicola Marcello , Krumov Julian , Kanellopoulos Anastasios D.
Published: July 2018

Background: Alteration of the posteromedial part of the proximal tibia is the main characteristic of Blount’s disease and if left untreated, leg alignment and normal development of the lower limbs may be compromised.

Aim: To report treatment outcomes in children with Blount’s disease using the Taylor Spatial Frame (TSF).

Materials and methods: From January 2007 to December 2014, 16 young children (24 tibia) with a mean age of 7.5 years (range of 3-14 yrs) and severe Blount’s disease were treated using TSF. Preoperative long standing radiographs were performed and anatomic medial proximal tibial angle (MPTA), diaphyseal-metaphyseal tibial angle (Drennan), femoro-tibial angle and leg length discrepancy (LLD) were measured.

Results: Post-operative improvement of all measurements was observed. MPTA increased from a mean of 71.8° (58° - 79°) to 92.5° (90° - 95°), the Drennan decreased from 16.6° (14° - 18°) to 3.6° (0° - 6°), the F-T angle changed from 15.4° (10° - 25°) of varus to 5.9° (2° - 10°) of valgus and the LLD decreased from 208 mm (150-320) to 69 mm (0- +120). Mean follow-up was 45.6 months. According to Paley’s criteria pin track infection was present in 6 tibiae, while in 5 patients software changes were necessary. Recurrence was observed in 3 patients (triplets). Complete restoration of the mechanical axis was obtained at the end of the treatment.

Conclusions: In the last decades, different surgical treatments have been proposed for Blount’s disease (tension band plate, staples, osteotomies using external or internal fixation). External fixation using the TSF allows gradual safe correction of multiplanar deformities and is a well-tolerated technique by patients with Blount’s disease.
Genetically Determined TNF-α Secretion Influences the Development of Dermatomyositis and Systemic Lupus Erythematosus
Authors: Dourmishev Lyubomir A. , Hristova Maria H. , Kamenarska Zornitsa G. , Savov Alexey S. , Vinkov Anton I. , Kaneva Radka , Mitev Vanjo
Published: July 2018

Background: Abnormal secretion of TNF-α is known to play a role in the pathogenesis of dermatomyositis and systemic lupus erythematosus.

Materials and methods: In the present study we have analyzed the concentrations of TNF-α in the sera of 30 patients with systemic lupus erythematosus (SLE), 28 with dermatomyositis (DM) and 30 healthy controls by standard ELISA tests.

Results: We have found that -308A allele increases TNF-α secretion, while -1031C and -863A alleles decrease it. The -857C/T and 489G/A polymorphisms appeared in strong linkage disequilibrium (D’=0.93) but they did not seem to affect TNF-α secretion.

Conclusion: TNF-α polymorphisms play a significant role in its secretion and influence the development of DM and SLE.