bluuebunny/crossref_metadata_2025 huggingface dataset:
Darek (Melia azedarach) - A potential root stock for raising vigorous Neem (Azadirachta indica) plants
Authors: SHARMA KAMAL , SHARMA SOM DUTT , KUMAR SANJEEV
Published: November 2022

Neem is an indigenous tree species with medicinal and pesticidal properties. It is generally raised through seed which ripens in August in northern India. The seed viability is only for few weeks and the nursery men are bound to sow the seed in nursery immediately after seed ripening i.e. in August. The initial growth in nursery is very slow and the seedlings are very tender and lanky in first growing season which lasts hardly for about three months in northern India. Moreover, the species is highly susceptible to frost and hence, it becomes very difficult to protect such tender seedlings during winter. To increase the period of growing season and produce vigorous nursery stock of Neem, it was thought to grow it on a potential root stock by way of budding/grafting. Darek (Melia azedarach) with wider adaptability in varied agroecological conditions was selected as a root stock. The experiment conducted in the month of February revealed excellent bud take, survival and growth. The budded plants attained a height of 8 ft in first growing season (February to November) as against just 4 inches of seedling origin plants. The technique has proved useful to enhance initial growth and to increase the growing period of Neem which resulted in production of tall and vigorous plants. The budding technique will also be very useful for cloning Neem. Further, experiments are required to be carried out for screening better genotypes of root stock (Darek) and scion (Neem) for improving growth and desirable traits of Neem.
Characterizing waterlogging tolerance using multiple selection indices in bread wheat (Triticum aestivum)
Authors: SINGH GYANENDRA , KUMAR PRADEEP , GUPTA VIKAS , TYAGI B S , SINGH CHARAN , SHARMA A K , SINGH G P
Published: November 2022

WL stress significantly affected grain yield, biological yield, tillers per meter, plant height and spike weight. The plant height, tillers per meter, spike weight, and biological yield were found to be positively and significantly correlated with grain yield under WL conditions. Among these traits, biological yield has maximum contribution towards WL tolerance and can be used for selection of tolerant genotypes. Significant and desirable correlation of different selection indices, viz. HM, MP, YSI, STI and PRGY indicated that any one of these can be used interchangeably to select stress tolerant genotypes.
Interdisciplinary Ideas for Fostering Social Connectedness Through Civic Involvement of Higher Education Students In Times Of Crisis
Authors: Rusu Alina Simona
Published: November 2022

This theoretical paper proposes an educational solution based on interdisciplinary curricular development (i.e., elements of neuroeducation, applied evolutionary psychology), which refers to the insertion in the existent curricula of a learning objective that has the potential to foster the development of social connectedness of HEI students in times of crisis. This learning objective is designed to increase the awareness of the students towards the mental health and survival-related benefits of helping others in needs not only to the beneficiaries from the community, but also to themselves. Also, it is assumed that this learning objective has the potential to foster the interest of the academic staff towards considering Service-Learning educational strategy as a valuable tool in the context of accomplishing the third mission of Higher Education Institutions.
Pedagogies Of Academic Writing For Undergraduate Students In Political Science: A Discussion On The Literature
Authors: Guțoiu Giorgian
Published: November 2022

Our paper discusses academic writing for political science undergraduate higher education students. In the first part it focuses on the main topics in academic writing in political science, such as citation, references list, academic style, plagiarism. The second part focuses on recent discussions of teaching strategies in the field. While depicting a global picture in discussing trends in the literature, the paper also employs a minor focus on Romania. The paper makes a contribution to understanding the literature on academic writing in undergraduate political science higher education and helps comprehend recent pedagogical trends and developments.
The Complete Genome Sequence of Polystichum acrostichoides (Dryopteridaceae, Polypodiales)
Authors: Raoui Sana , Pirro Stacy , Amzazi Saaïd , Ghazal Hassan
Published: November 2022

Polystichum acrostichoides is a perennial, evergreen fern, commonly found in woodlands, stream banks, and rocky slopes in eastern North America. We present the whole genome sequence of this species. Illumina sequencing was performed on a leaf tissue sample from a single plant collected in Maryland, USA. The reads were assembled using a de novo method followed by a finishing step using series of references from related species. The raw and assembled data are publicly available via GenBank: Sequence Read Archive (SRR18053988) and Genome Assembly (JAOYMV000000000).
Pathogenesis of Sepsis
Authors: Anggraini Debie , Hasni Dita , Amelia Rinita
Published: November 2022

Sepsis is a clinical condition caused by the body's immune response to infection and manifests as SIRS. Systemic inflammatory response syndrome is a state of systemic inflammatory response characterized by two or more of the following conditions. Etiology  Sepsis can be caused by various microorganisms and the most etiology of sepsis is bacterial. Gram-negative bacteria cause sepsis about 60% - 70% in developing countries, but in the United States the causes of infection by Gram-positive bacteria begin to increase. This may be due to the large number of uses of invasive procedures, increased hospital acquired pneumonia (HAP) and antibiotic resistance. The body also has anti-inflammatory mechanisms including increased levels of anti-inflammatory cytokines and glucocorticoid hormones. The hormone inhibits the synthesis of cytokines by monocytes and decreases the ability of neutrophils to attach to the vascular endothelium. The inflammatory process in sepsis is not controlled leading to the occurrence of excessive discharge of inflammatory mediators over a long time and goes beyond the anti-inflammatory mechanisms of the body. This leads to various organ dysfunctions including cardiovascular, liver, pulmonary and renal dysfunctions
Supercritical Fluid Chromatography for Chiral Analysis, Part 1: Theoretical Background
Authors: Roskam Gerry , van de Velde Bas , Gargano Andrea , Kohler Isabelle
Published: November 2022

The quantification of the enantiomers of racemic substances is of great importance in the development and regulation of pharmaceutical compounds. Active ingredients are often chiral; typically, only one of the stereoisomers has the desired pharmacokinetic and/or pharmacodynamic properties. Therefore, the stereoisomer distribution of chiral drug products must be characterized and evaluated during the drug discovery and development pipeline. Moreover, various chiral drugs present a stereoselective metabolism, highlighting the need for appropriate analytical strategies for the stereoselective analysis of metabolites, for example, in clinical and environmental studies. Due to its ease of use, robustness, and transferability, chiral liquid chromatography (LC) is the most common approach used in pharmaceutical analysis. Compared with LC, supercritical fluid chromatography (SFC) allows higher linear flow velocities while maintaining high chromatographic efficiency, often enabling the reduction of analysis time. In addition, SFC provides enhanced or complementary chiral selectivity and avoids or reduces toxic solvents, such as those used in normal-phase LC. In the first part of this review article the theoretical advantages, technological developments, and common practices in chiral SFC are discussed. This will be followed by a contribution discussing recent applications in pharmaceutical, clinical, forensic, and environmental analysis.
Development and Validation of a Serpent-2 Model for the Former 3 MW TRIGA Core Configuration of the Philippine Research Reactor-1
Authors: Jecong Julius Federico , Hila Frederick , Dingle Cheri Anne , Astronomo Alvie , Gatchalian Ronald Daryll , Romallosa Kristine Marie , Guillermo Neil Raymund
Published: November 2022

The 3 MW TRIGA (Training, Research, Isotopes, General Atomics) Philippine Research Reactor-1 (PRR-1) at the DOST-PNRI achieved its first criticality on 08 Mar 1988 after its successful upgrade from a plate-type reactor. However, due to unresolved technical problems discovered weeks after the upgrade, the PRR-1 was considered inoperable and has been in shutdown status since then. The slightly irradiated TRIGA fuel rods of the PRR-1 are currently in an interim storage tank and are planned to be utilized in a subcritical reactor assembly. As part of the project to reuse the fuels, simulation models for both present and proposed configurations are important. In this work, we present the complete model of the former configuration of PRR-1 with 115 TRIGA fuel rods developed with the Serpent Monte Carlo code version 2 for simulation of criticality and neutronic analysis. The model of the TRIGA fuel rods was validated in the fresh fuel configuration through the benchmark analysis described in the 1988 reactor criticality report. The effective multiplication factors from the Serpent-2 simulation (𝒌𝒆𝒇𝒇 = 1.0690 ± 0.0012) and measured value of 1.0661 have been found to agree with a deviation of 259 pcm. Neutron flux and fission power distribution simulations using the same reactor configuration were also presented to serve as reference for future burn up calculations and fuel characterization.
Impact d'une catastrophe sur l'avenir d'un site industriel urbain. Les cas de Lyon et Toulouse
Authors: Cauhopé Marion , Duchêne François , Jaillet Marie-Christine
Published: November 2022

La recherche présentée ici s’intéresse aux processus de qualification et de déqualification d’espaces industriels situés en milieu urbain. En effet, à partir de l’étude des arbitrages entre recherche de sécurité et développement urbain dans le contexte particulier d’un site industriel sinistré, il s’agit de voir en quoi la catastrophe s’impose comme un temps brutal, et parfois irréversible, de déqualification d’un espace dédié jusque-là à l’industrie. Ces travaux entendent montrer comment s’opèrent les arbitrages en situation de crise, la prégnance de la catastrophe et de l’émotion qu’elle suscite dans les décisions à court terme. L’un de leurs intérêts réside dans la mise en perspective de deux cas de sites sinistrés. Il s’agit tout d’abord du pôle chimique sud-toulousain, dévasté par l’explosion dans l’usine d’engrais AZF le 21 septembre 2001. Cet accident a entraîné la mort de 31 personnes, des blessures pour de nombreuses autres, et de multiples dégâts matériels dans toute la ville de Toulouse. L’autre cas concerne l’incendie du dépôt pétrolier Shell dans le port industriel Édouard Herriot de Lyon en juin 1987, ayant causé la mort de deux personnes.
COLOPHONS OF ARMENIAN MANUSCRIPTS XIV CENTURY Part II (1326-1350)
Authors: KHACHIKYAN LEVON , MATEVOSYAN ARTASHES , GHAZAROSYAN ARPENIK
Published: November 2022

Ժողովածուն ընդգրկում է 1326-1350 թվականներին գրված հայերեն ձեռագրերի հիշատակարանները, որոնց մի մասը հրատարակել է Լ. Խաչիկյանը (1918-1982) «ԺԴ դարի հայերեն ձեռագրերի հիշատակարաններ» գրքում (1950 թ.), մյուս մասը լրացրել են Ա. Մաթևոսյանը (1922-2004) և Ա. Ղազարոսյանը։
HAKOB PAPAZIAN ARTICLES Volume I
Authors: Kostikyan Kristine
Published: November 2022

Հակոբ Փափազյանի հոդվածների ժողովածուի առաջին հատորում ընդգրկված են անվանի գիտնականի՝ 1953-1972 թթ. հրապարակված հոդվածները, նվիրված՝ արևելագիտության ու հայագիտության տարբեր ոլորտներին։ Ժողովածուն նախատեսված է հայագետների, իրանագետների, արաբագետների և թուրքագետների, ինչպես նաև հայագիտության և արևելագիտության խնդիրներով հետաքրքրված ընթերցողների համար։
HRAVARD HAKOBYAN THE ART DEVOTEE BIOGRAPHICAL REFERENCE SOURCES
Authors: Hakobyan Hravard
Published: November 2022

Մատենագիտությունն ընդգրկում է Հ. Հակոբյանի 1966-2020 թվականների տպագիր աշխատանքների ցանկը՝ նրա գիտական գործունեությունը բնութագրող համառոտ ակնարկով: Ժողովածուում տեղ են գտել նաև Հ. Հակոբյանի գիտական գործունեությունն արժևորող հոդվածներ։
Ultrasound-Guided Posterior Tibial Nerve Block for Frostbite of the Plantar Surfaces: A Case Series
Authors: Burl Taylor , Latshaw Parker , Dreyfuss Andrea
Published: November 2022

Introduction: Frostbite is a painful condition that requires rapid identification and wound care to optimize outcomes. The posterior tibial nerve (PTN) block, however, has yet to be described in the literature for pain control of frostbite injuries on the plantar surfaces.

Case Series: In this case series we discuss three patients who presented with bilateral frostbite on the plantar surfaces. Ultrasound-guided PTN blocks were performed on these patients and pain control was achieved in under 10 minutes, facilitating burn care. No patient experienced adverse effects. All patients had been scheduled for future debridement that was either not performed or performed using intravenous (IV) medications due to pain control issues.

Conclusion: The ultrasound-guided PTN block facilitated proper wound debridement that was previously intolerable with oral and IV pain medications. This case series highlights the efficacy, safety, and accessibility of this block for frostbite pain control in the emergency department. Additionally, it emphasizes the potential role of ultrasound-guided PTN blocks as part of a multi-modal pain control strategy in other clinical settings.
Point-of-Care Ultrasound Diagnosis of Tetralogy of Fallot Causing Cyanosis: A Case Report
Authors: Addepalli Aravind , Guillen Marco , Dreyfuss Andrea , Mantuani Daniel , Nagdev Arun , Martin David
Published: November 2022

Introduction: Tetralogy of Fallot (TOF) is a congenital heart defect with characteristic features leading to unique physical exam and ultrasound findings. In settings where there is limited prenatal screening, TOF can present with cyanosis at any time from the neonatal period to adulthood depending on the degree of obstruction of the right ventricular outflow tract.

Case Report: This case describes a pediatric patient who presented with undifferentiated dyspnea and cyanosis, for whom point-of-care ultrasound (POCUS) supported the diagnosis of TOF. We highlight the important role POCUS can play in a setting with limited access to formal echocardiography or consultative pediatric cardiology services. 

Conclusion: This report highlights the utility of POCUS as an inflection point in the diagnostic and management pathway of this patient, which is particularly important when working in a limited-resource or rural setting.
Legionnaires’ Disease Causing Severe Rhabdomyolysis and Acute Renal Failure: A Case Report
Authors: Branstetter Andrew , Wyler Benjamin
Published: November 2022

Introduction: Legionnaires’ disease is a multisystem disease involving respiratory, gastrointestinal, and neurologic systems. This is a case of a previously healthy 44-year-old man who was diagnosed with Legionella pneumonia causing acute kidney failure and rhabdomyolysis.

Case Report: The patient presented with four days of chills, shortness of breath, chest discomfort, diarrhea, and myalgias. Laboratory testing revealed hyponatremia, leukocytosis, elevated inflammatory markers, renal failure, and rhabdomyolysis. He was admitted to the intensive care unit for acute hypoxemic respiratory failure, received a course of antibiotics, and more than two weeks of intermittent hemodialysis with full recovery of renal function. The pathophysiologic mechanisms by which Legionella causes rhabdomyolysis and acute kidney failure are not fully understood, although numerous mechanisms have been proposed including direct invasion of myocytes and renal tubular cells.

Conclusion: Legionnaires’ disease is one of several infections that can cause rhabdomyolysis and kidney failure. Although rarely described in the literature, it is important for emergency physicians to be aware of this clinical entity in order to implement early diagnostic testing and empiric treatment.
Life-Threatening Complications Associated with Bladder Decompression: A Case Report
Authors: Knapp Barry , Apgar Lauren , Pennell Kirstin
Published: November 2022

Introduction: The clinical course of patients who present to the emergency department (ED) with urinary retention is usually uneventful. In this case, we explore the life-threatening complications of urinary retention and bladder decompression.

Case Report: We report the case of a 57-year-old man who presented to the ED with difficulty voiding. A urinary catheter was placed. The patient had severe post-obstructive diuresis. He developed hematuria and became hypotensive. After aggressive resuscitation, including blood products, the patient required operative intervention for hemorrhage control.

Conclusion: Clinicians should be aware of and be able to manage the rare but life-threatening complications associated with urinary retention.
CОMBINING PERIO-RESTORATIVE PROTOCOLS TO MAXIMIZE FUNCTION
Authors: Tucker Lloyd , Melker Daniel , Chasolen Howard
Published: November 2022

Many of today‘s patients have restorative needs that often require the replacement of existing dentistry.
Often, caries removal and the establishment of a new restorative margin places the anticipated new restorations in an apical or more subgingival position, which presents a number of biologic and mechanical problems that could downgrade the long-term prognosis of both the periodontal health and the restorations. In order to achieve superior restorative results, periodontal corrective procedures are necessary to return the foundation to a healthy state. Traditionally, crown lengthening was indicated for
deep subgingival margins not only to facilitate impression taking, but to correct biologic width impingement. Attempting to take impressions or to cement or bond restorations in this septic environment, and expecting good results, is unrealistic. A combined periodontal/restorative protocol termed biologic shaping has been documented to address these issues with predictable, reproducible clinical precision and long-term success.
Artistic Genius and Freedom of Creativity in Kant’s Critique of Judgement
Authors: Tolsma Rintje Theoren ,   Institute for Interdisciplinary Research
Published: November 2022

This essay explores Immanuel Kant’s notion of artistic genius and how it relates to the modern conception of the interrelated ideas of nature and freedom as they appear in his Critique of Judgement. Genius works as a unique concept in Kant’s oeuvre, showing how art provides a harmony within what, in Reformational philosophy, they call the “ground-motive” “nature-freedom.” The concept of originality as it relates to genius has the potential for an alternative reading to what was held subsequent to Kant and what is still held today, one that puts the emphasis on a certain relationality. Hannah Arendt’s conception of freedom and Jacques Derrida’s reading of Kant are also relevant. This essay’s reading of Kant’s genius, defined by its multifaceted network of relational forces, shows a way out of the bind of the binary nature and freedom. By explicating Kant’s notion of artistic genius, one is able to better understand art and its function: probing the complex relationship that humans have with themselves and the rest of creation.
Adults’ use of subtraction by addition and its association with executive functions
Authors: Van Der Auwera Stijn , De Smedt Bert , Torbeyns Joke , Verschaffel Lieven
Published: November 2022

This study examined adults’ frequent, efficient and adaptive use of direct subtraction (DS) and subtraction by addition (SBA) in mental multi-digit subtraction with the choice/no-choice method. Participants were offered subtractions in one choice condition (choice between DS and SBA) and two no-choice conditions (mandatory use of either DS or SBA). SBA was used as frequently as DS in the choice condition. DS was most accurate on subtractions with a large difference (e.g., 502 – 18), while SBA was fastest on subtractions with a small difference (e.g., 903 – 886). In general, participants were adaptive for task characteristics and their personal speed characteristics. We further analyzed task-based adaptivity on an individual level via a Latent Class Analysis. Results showed that two-thirds of the participants were adaptive to task characteristics, and that these adaptive participants were the most proficient in accuracy and speed in the choice condition. We further examined whether executive functions (updating, inhibition, shifting) were related to individual differences in strategy efficiency and task-based adaptivity. In line with our hypothesis, updating was related to strategy efficiency, such that participants with higher updating skills were more accurate. In contrast to our expectations, inhibition and shifting were not related to task-based strategy adaptivity. This study highlights adults’ efficient and adaptive use of arithmetic strategies, and its association with their proficiency and executive functions.
Flexibility and adaptivity in arithmetic strategy use: What children know and what they show
Authors: Hickendorff Marian
Published: November 2022

Central elements of adaptive expertise in arithmetic problem solving are flexibility, using multiple strategies, and adaptivity, selecting the optimal strategy. Research shows that the strategies children actually use do not fully reflect the strategies they know: there is hidden potential. In the current study a sample of 147 third graders from the Netherlands completed a comprehensive assessment of adaptive expertise in the domain of multidigit subtraction, designed to measure, first, the strategies students know and use to solve subtraction problems (potential and practical flexibility). Second, it measured to what extent students know which strategy is optimal and to what extent they use the optimal strategy (potential and practical adaptivity). Findings for flexibility showed that most students consistently used the same strategy across all problems: practical flexibility was low. When prompted, students knew more strategies than they used spontaneously, suggesting hidden potential in flexibility. Findings for adaptivity showed that students hardly ever spontaneously used the task-specific strategy that is efficient for specific problems since it has the fewest and easiest steps. However, almost half of the students could select this strategy from a set of given strategies at least once. Furthermore, an innovative, personalized version of the choice/no-choice method showed that the task-specific strategy was usually not the optimal strategy (fastest strategy leading to a correct answer) for individual students. Finally, students used the strategy with which they performed best more often than the other strategies, but there is hidden potential for the adaptive use of task-specific strategies.
The role of domain-general and domain-specific skills in the identification of arithmetic strategies
Authors: Eaves Joanne , Attridge Nina , Gilmore Camilla
Published: November 2022

Individuals solve arithmetic problems in different ways and the strategies they choose are indicators of advanced competencies such as adaptivity and flexibility, and predict mathematical achievement. Understanding the factors that encourage or hinder the selection of different strategies is therefore important for helping individuals to succeed in mathematics. Our research contributed to this goal by investigating the skills required for selecting the associativity shortcut-strategy, where problems such as ‘16 + 38 – 35’ are solved by performing the subtraction (38 – 35 = 3) before the addition (3 + 16 = 19). In a well-powered, pre-registered study, adults completed two tasks that involved ‘a + b – c’ problems, and we recorded a) whether and b) when, they identified the shortcut. They also completed tasks that measured domain-specific skills (calculation skill and understanding of the order of operations) and domain-general skills (working memory, inhibition and switching). Of all the measures, inhibition was the most reliable predictor of whether individuals identified the shortcut, and we discuss the roles it may play in selecting efficient arithmetic strategies.
ISEA 2022 Barcelona
Authors: Vilà Irma
Published: November 2022

El Simposio Internacional de Arte Electrónico ISEA celebró su 27.ª edición en Barcelona después de 10 años sin aterrizar en Europa, puesto que cada año se celebra en una ciudad diferente. Esta edición, impulsada por la UOC, reunió a una comunidad de más de 750 expertos en arte, ciencia y tecnología, así como a artistas digitales nacionales e internacionales. ISEA2022 Barcelona ofreció al público general numerosas actividades en abierto, como talleres, conferencias y performances. Además, extendió su programación a diversos puntos de Barcelona y Cataluña, lo que supuso un impacto de más de 45.000 asistentes entre participantes, público y visitantes.
Binary and analog variation of synapses between cortical pyramidal neurons
Authors: Dorkenwald Sven , Turner Nicholas L , Macrina Thomas , Lee Kisuk , Lu Ran , Wu Jingpeng , Bodor Agnes L , Bleckert Adam A , Brittain Derrick , Kemnitz Nico , Silversmith William M , Ih Dodam , Zung Jonathan , Zlateski Aleksandar , Tartavull Ignacio , Yu Szi-Chieh , Popovych Sergiy , Wong William , Castro Manuel , Jordan Chris S , Wilson Alyssa M , Froudarakis Emmanouil , Buchanan JoAnn , Takeno Marc M , Torres Russel , Mahalingam Gayathri , Collman Forrest , Schneider-Mizell Casey M , Bumbarger Daniel J , Li Yang , Becker Lynne , Suckow Shelby , Reimer Jacob , Tolias Andreas S , Macarico da Costa Nuno , Reid R Clay , Seung H Sebastian
Published: November 2022

Learning from experience depends at least in part on changes in neuronal connections. We present the largest map of connectivity to date between cortical neurons of a defined type (layer 2/3 [L2/3] pyramidal cells in mouse primary visual cortex), which was enabled by automated analysis of serial section electron microscopy images with improved handling of image defects (250 × 140 × 90 μm3 volume). We used the map to identify constraints on the learning algorithms employed by the cortex. Previous cortical studies modeled a continuum of synapse sizes by a log-normal distribution. A continuum is consistent with most neural network models of learning, in which synaptic strength is a continuously graded analog variable. Here, we show that synapse size, when restricted to synapses between L2/3 pyramidal cells, is well modeled by the sum of a binary variable and an analog variable drawn from a log-normal distribution. Two synapses sharing the same presynaptic and postsynaptic cells are known to be correlated in size. We show that the binary variables of the two synapses are highly correlated, while the analog variables are not. Binary variation could be the outcome of a Hebbian or other synaptic plasticity rule depending on activity signals that are relatively uniform across neuronal arbors, while analog variation may be dominated by other influences such as spontaneous dynamical fluctuations. We discuss the implications for the longstanding hypothesis that activity-dependent plasticity switches synapses between bistable states.
Prediction of stock price direction using the LASSO-LSTM model combines technical indicators and financial sentiment analysis
Authors: Yang Junwen , Wang Yunmin , Li Xiang
Published: November 2022

Correctly predicting the stock price movement direction is of immense importance in the financial market. In recent years, with the expansion of dimension and volume in data, the nonstationary and nonlinear characters in finance data make it difficult to predict stock movement accurately. In this article, we propose a methodology that combines technical analysis and sentiment analysis to construct predictor variables and then apply the improved LASSO-LASSO to forecast stock direction. First, the financial textual content and stock historical transaction data are crawled from websites. Then transfer learning Finbert is used to recognize the emotion of textual data and the TTR package is taken to calculate the technical indicators based on historical price data. To eliminate the multi-collinearity of predictor variables after combination, we improve the long short-term memory neural network (LSTM) model with the Absolute Shrinkage and Selection Operator (LASSO). In predict phase, we apply the variables screened as the input vector to train the LASSO-LSTM model. To evaluate the model performance, we compare the LASSO-LSTM and baseline models on accuracy and robustness metrics. In addition, we introduce the Wilcoxon signed rank test to evaluate the difference in results. The experiment result proves that the LASSO-LSTM with technical and sentiment indicators has an average 8.53% accuracy improvement than standard LSTM. Consequently, this study proves that utilizing historical transactions and financial sentiment data can capture critical information affecting stock movement. Also, effective variable selection can retain the key variables and improve the model prediction performance.
Functional expression and purification of DoxA, a key cytochrome P450 fromStreptomyces peucetiusATCC 27952
Authors: Yang Liyan , Yang Dengfeng , Wang Qingyan , Li Juan , Li Hong-Liang , Pan Lixia
Published: November 2022

The antitumor drug doxorubicin is widely used in clinical practice. However, the low yield and high cost of this drug highlight the urgent need for cost-effective processes to rapidly manufacture antitumor drugs at scale. In the biosynthesis pathway, the multi-functional cytochrome P450 enzyme DoxA catalyzes the last three steps of hydroxylation. The final conversion of daunorubicin to doxorubicin is the rate-limiting step. In our work, the DoxA has been expressed with the ferredoxin reductase FDR2 and the ferredoxin FDX1 and purified to homogeneous. The reduced carbon monoxide difference spectroscopy, heme concentration, and enzymatic characteristic were characterized. These studies suggest an approach for engineeringStreptomycesP450s with functional expression for mechanistic and structural studies.
Effect of Different Nano-NPK Fertilizers on Vegetative Growth Parameter and Soil Microbial Activity of Fig Crop under Different Irrigation Regims
Authors: Mustafa N. S. A. , Shaarawy H. H. , El-Dahshouri M. F. , El-Saady A. M. , Mahfouze Sherin A. , Matter Ibrahim A. , Zhang Lixin , El-berry I. M.
Published: November 2022

World face several challenges the most decisive climatic changes , freshwater poverty and poor usage efficiency for natural resources (soil & water) particularly in developing countries.

Applying Nanotechnology may represent a smart mechanism toward sustainable agricultural. Much efforts have been exerted to utilizing nano-technology and producing agro-chemicals in nano-form i.e, nano-fertilizers and nano-pesticides.

Current work that carried out in greenhouse belong pomology department , National Research Centre, Cairo, Egypt during 2020/2021, aims to assessing impact of nano-fertilizers on growth performance and soil microbial activity under different drought stress levels. NPK-nano-fetrilizer was applied on uniform one-year old fig seedlings,  as foliar application at two levels (200 and 400ppm) compared with traditional NPK fertilizer, under three levels of water regimes (once, twice and three times irrigation weekly. Obtained results indicated that under drought stress nano-fertilizers enhanced fig seedlings growth performance and nutrient content. Moreover, nano-fertilizer raised antioxidant enzyme activity that work on scavenging active oxygen species and thereby reinforce drought stress tolerance in plants. Besides, nano-fertilizer had a positive impact on soil microbial under low soil moisture. This study came in chain of studies which proved the efficiency of nano-fertilizer under drought stress with no negative impact on environments under this study conditions.  This study concluded that nano-fertilizer has a bright future particularly under challenges that face the world (climatic changes, poverty of water resources, soil degradation and global food famine risk with fast growing of population)   toward sustainable agriculture  with low risk on environment.
Analysis of COVID-19 Vaccination Status Among Parents of Hospitalized Children Younger Than 5 Years With SARS-CoV-2 Infection During the Delta and Omicron Waves
Authors: Solignac Florie , Ouldali Naïm , Aupiais Camille , Casha Paul , Cohen Robert , Levy Corinne , Angoulvant François
Published: November 2022

This cohort study uses COVID-19 Pediatric Observatory study data to analyze the vaccination status of parents with young children hospitalized for SARS-CoV-2 variants Delta and Omicron.
Medical workforce in the United States
Authors: Bluth Edward I. , Frush Donald P. , Oates M. Elizabeth , LaBerge Jeanne , Pan Hubert Y. , Newhauser Wayne D. , Rosenthal Seth A.
Published: November 2022

This section focuses on the professional workforce comprised of the primary medical specialties that utilize ionizing radiation in their practices. Those discussed include the specialties of radiology and radiation oncology, as well as the subspecialties of radiology, namely diagnostic radiology, interventional radiology, nuclear radiology, and nuclear medicine. These professionals provide essential health care services, for example, the interpretation of imaging studies, the provision of interventional procedures, radionuclide therapeutic treatments, and radiation therapy. In addition, they may be called on to function as part of a radiologic emergency response team to care for potentially exposed persons following radiation events, for example, detonation of a nuclear weapon, nuclear power plant accidents, and transportation incidents. For these reasons, maintenance of an adequate workforce in each of these professions is essential to meeting the nation's future needs. Currently, there is a shortage for all physicians in the medical radiology workforce.
Electromechanical Behavior of Al/Al2O3Multilayers on Flexible Substrates: Insights from In Situ Film Stress and Resistance Measurements
Authors: Putz Barbara , Edwards Thomas E.J. , Huszar Emese , Gruber Patric A. , Gradwohl Kevin‐P. , Kreiml Patrice , Többens Daniel M. , Michler Johann
Published: November 2022

A series of Al and Al/Al2O3thin‐film multilayer structures on flexible polymer substrates are fabricated with a unique deposition chamber combining magnetron sputtering (Al) and atomic layer deposition (ALD, Al2O3, nominal thickness 2.4–9.4 nm) without breaking vacuum and thoroughly characterized using transmission electron microscopy (TEM). The electromechanical behavior of the multilayers and Al reference films is investigated in tension with in situ X‐ray diffraction (XRD) and four‐point probe resistance measurements. All films exhibit excellent interfacial adhesion, with no delamination in the investigated strain range (12%). For the first time, an adhesion‐promoting naturally forming amorphous interlayer is confirmed for thin films sputter deposited onto polymers under laboratory conditions. The evolution of Al film stresses and electrical resistance reveal changes in the deformation behavior as a function of oxide thickness. Strengthening of Al is observed with increasing oxide thickness. Significant embrittlement can be avoided for oxide layer thicknesses ≤2.4 nm.
Sinter‐Based Additive Manufacturing of Graded Porous Titanium Scaffolds by Multi‐Inks 3D Extrusion
Authors: Coffigniez Marion , Gremillard Laurent , Boulnat Xavier
Published: November 2022

A 3D printing approach to design and produce cellular scaffolds with a precise tunable pore architecture, in terms of size, fraction, and interconnectivity is reported. Different metallic inks are formulated by mixing hydrogel with Ti–6Al–4V atomized powders of various sizes. After 3D printing by direct‐ink writing (DIW) followed by debinding and sintering, the fraction and size of macropores (, designed by computer‐aided design (CAD)) and micropores (, remaining after sintering), the roughness and the microstructure are determined by high‐resolution X‐ray tomography and electron microscopy, and correlated to the initial powder size. It is shown that playing with initial powder size allows designing different pore architectures, from interconnected micropores to fully dense filaments. These phenomena are combined with a multi‐inks DIW approach to fabricate architectured structures with graded microporosity. This new route is promising for the production of functional materials, such as biomedical scaffolds or implants, with tunable osseointegration, stiffness, and strength. The micropores could also be loaded with active molecules and positioned according to release needs.
Physical Cue‐Based Strategies on Peripheral Nerve Regeneration
Authors: Wei Zhidong , Jin Fei , Li Tong , Qian Lili , Zheng Weiying , Wang Ting , Feng Zhang‐Qi
Published: November 2022

Peripheral nerve injury (PNI) remains an intractable challenge in regenerative medicine. Recently, physical cue‐based strategies (e.g., electrical neurostimulation, acoustic radiation, electromagnetic bioregulation, as well as directional fiber guiding, etc.) have drawn increasing attention not only as a stimulator for cell functions modulation and fate determination, but also as a morphology‐index for modulating cell phenotype, proliferation, and differentiation, especially for nerve cells. More importantly, the advanced percutaneous power transmission technology, self‐power nanotechnology that leverages piezoelectrical/triboelectricity materials, and focused ultrasound and pulsed electromagnetic field technology exhibit the appealing practice potential for achieving low‐invasive, wireless, and battery‐free neuromodulation. In this review, recent advances of physical cue‐based strategies including electrical, acoustic, magnetic, and morphology for PNI are systematically overviewed, and the open challenges for realizing scalable clinical/commercial transformation and future perspectives of these strategies for PNI are concluded.
Synthetic Monosaccharide Channels: Size‐Selective Transmembrane Transport of Glucose and Fructose Mediated by Porphyrin Boxes
Authors: Lee Hong‐Guen , Dhamija Avinash , Das Chandan K. , Park Kyeng Min , Chang Young‐Tae , Schäfer Lars V. , Kim Kimoon
Published: November 2022

Here we report synthetic monosaccharide channels built with shape‐persistent organic cages, porphyrin boxes (PBs), that allow facile transmembrane transport of glucose and fructose through their windows.PBs show a much higher transport rate for glucose and fructose over disaccharides such as sucrose, as evidenced by intravesicular enzyme assays and molecular dynamics simulations. The transport rate can be modulated by changing the length of the alkyl chains decorating the cage windows. Insertion of a linear pillar ligand into the cavity ofPBs blocks the monosaccharide transport. In vitro cell experiment shows thatPBs transport glucose across the living‐cell membrane and enhance cell viability when the natural glucose transporter GLUT1 is blocked. Time‐dependent live‐cell imaging and MTT assays confirm the cyto‐compatibility ofPBs. The monosaccharide‐selective transport ability ofPBs is reminiscent of natural glucose transporters (GLUTs), which are crucial for numerous biological functions.
Hydrodynamics and film formation characteristics in a horizontal self‐cleaning twin‐shaft kneader for polymer devolatilization
Authors: An Shu , Liao Zuwei , Hong Xiaodong , Huang Zhengliang , Yang Yao , Sun Jingyuan , Wang Jingdai , Yang Yongrong
Published: November 2022

A deep understanding of hydrodynamics and film formation characteristics is a prerequisite for the design of twin‐shaft kneaders. In this work, the hydrodynamics and film formation characteristics of a self‐cleaning twin‐shaft kneader are investigated using computational fluid dynamics method. Because of the intermeshing interaction and scratching action of the kneader rods, both bounded films and free films coexist in the kneader. Since both shafts rotate clockwise, more liquid is accumulated in the left cylinder. The liquid level of the left cylinder is higher which reduces the film formation rate of the left zone. The film formation rate in the right zone is 1.3–1.8 times that of the left zone and overlapping zone. The differences between the left and right cylinders would cause inconsistent devolatilization performances. To reduce the negative effects of asymmetric level, a static kneading rod is used to reduce the liquid level of the left zone and increase the film formation rate by 15%. We notice that adding a static kneading rod reduces the power consumption by 10%–30% compared with increasing the rotating speed to the same film formation rate. It could be an efficient method for polymer devolatilization.
Risk factors for complications and implant loss after prepectoral implant-based immediate breast reconstruction: medium-term outcomes in a prospective cohort
Authors: Dave R V , Vucicevic A , Barrett E , Highton L , Johnson R , Kirwan C C , Harvey J R , Murphy J
Published: November 2022

Background

Prepectoral implant-based breast reconstruction with acellular dermal matrix has become an increasingly popular option for selected patients. There are no randomized data to demonstrate short- or long-term outcomes. Cohort studies to date have demonstrated safety, but risk factors for complications are unknown.

Methods

A prospective cohort study of all patients undergoing prepectoral implant-based breast reconstruction between 2013 and 2019. Clinical factors and those related to reconstruction were analysed in relation to complications and implant loss using univariable and multivariable logistic regression.

Results

A total of 469 reconstructions were undertaken in 289 women; the majority of reconstructions were performed using a one-stage direct-to-implant technique with acellular dermal matrix. Median follow-up was 21 (range 2–71) months. Minor complications were seen after 11·2 per cent of reconstructions, major complications after 5·9 per cent, and the rate of implant loss by 3 months was 3·1 per cent. In the final multivariable model, sentinel node biopsy (odds ratio (OR) 5·06, 95 per cent c.i. 2·00 to 12·80), axillary clearance (OR 6·67, 1·17 to 37·94) and adjuvant radiotherapy (OR 7·11, 1·60 to 31·61) were independent risk factors for development of a major complication, and sentinel node biopsy (OR 4·32, 1·23 to 15·22) for implant loss.

Conclusion

Prepectoral implant-based breast reconstruction has acceptable medium-term results but careful patient selection is advised.
A redox‐reactive delivery system via neural stem cell nanoencapsulation enhances white matter regeneration in intracerebral hemorrhage mice
Authors: Lei Xuejiao , Hu Quan , Ge Hongfei , Zhang Xuyang , Ru Xufang , Chen Yujie , Hu Rong , Feng Hua , Deng Jun , Huang Yan , Li Wenyan
Published: November 2022

Intracerebral hemorrhage (ICH) poses a great threat to human health because of its high mortality and morbidity. Neural stem cell (NSC) transplantation is promising for treating white matter injury following ICH to promote functional recovery. However, reactive oxygen species (ROS)‐induced NSC apoptosis and uncontrolled differentiation hindered the effectiveness of the therapy. Herein, we developed a single‐cell nanogel system by layer‐by‐layer (LbL) hydrogen bonding of gelatin and tannic acid (TA), which was modified with a boronic ester‐based compound linking triiodothyronine (T3). In vitro, NSCs in nanogel were protected from ROS‐induced apoptosis, with apoptotic signaling pathways downregulated. This process of ROS elimination by material shell synergistically triggered T3 release to induce NSC differentiation into oligodendrocytes. Furthermore, in animal studies, ICH mice receiving nanogels performed better in behavioral evaluation, neurological scaling, and open field tests. These animals exhibited enhanced differentiation of NSCs into oligodendrocytes and promoted white matter tract regeneration on Day 21 through activation of the αvβ3/PI3K/THRA pathway. Consequently, transplantation of LbL(T3) nanogels largely resolved two obstacles in NSC therapy synergistically: low survival and uncontrolled differentiation, enhancing white matter regeneration and behavioral performance of ICH mice. As expected, nanoencapsulation with synergistic effects would efficiently provide hosts with various biological benefits and minimize the difficulty in material fabrication, inspiring next‐generation material design for tackling complicated pathological conditions.
Development of an LC/MS/MS Method for Simultaneous Detection of 11 Polyphenols in Rat Plasma and Its Pharmacokinetic Application after Oral Administration of Coreopsis tinctoria Extract
Authors: Han Haixia , Ma Rui , Xie Aidi , Gao Juanjuan , Wang Zhen , Zhao Yi , Pang Huanming , Zhang Wei
Published: November 2022

Eleven polyphenols, classified as flavonoid glycosides, flavonoid aglycones, and phenolic acids, are important bioactive components in the capitula of Coreopsis tinctoria (CCT). Nevertheless, their full pharmacokinetic profiles have not been demonstrated simultaneously. Therefore, a liquid chromatography – tandem mass spectrometry (LC/MS/MS) method was developed in the present work and used it to study the pharmacokinetics of these 11 compounds. We performed LC/MS/MS with a gradient mobile phase composed of water containing 0.1 % formic acid and acetonitrile containing 0.1 % formic acid on a Proshell 120 SB C18 column (2.1 mm×100 mm, 2.7 μm). We achieved a good chromatographic peak shape, resolution, and mass signal response, and multiple reaction monitoring facilitated the simultaneous detection of 11 analytes. In addition, we validated the selectivity, correlation coefficient, precision, extraction recovery, matrix effects, and stability of the LC/MS/MS method to be acceptable for 11 analytes in rat plasma. Subsequently, rats were orally administered with 50 % ethanol eluent of CCT (ECCT). Nine of 11 polyphenols were absorbed quickly (except for QCD and TCA), and their plasma levels peaked within 40 min. The exposure and Cmax values of flavonoid glycosides and phenolic acids were lower than those of flavonoid aglycones. This is the first report to demonstrate the pharmacokinetics of 11 polyphenols in ECCT, which may play an important role in future studies of the bioactive components of ECCT and their bioactive mechanisms.
Concepts of Heterogeneously Catalyzed Liquid‐Phase Oxidation of Cyclohexene with tert‐Butyl Hydroperoxide, Hydrogen Peroxide and Molecular Oxygen
Authors: Büker Julia , Muhler Martin , Peng Baoxiang
Published: November 2022

The oxidation of hydrocarbons is of great significance for the chemical industry as it provides access to valuable functionalized chemicals. The oxidation of cyclohexene has raised much interest because it enables the direct synthesis of adipic acid, which is an important building block in polymer chemistry. However, the selective oxidation of cyclohexene is rather challenging due to its two reactive centers so that epoxidation or allylic oxidation may occur leading to a variety of products. Whether the oxidation takes place at the allylic C−H bond or at the C=C bond is strongly influenced by the chosen oxidant and catalyst, and different reaction mechanisms can occur. Therefore, this concept article aims at giving a broad overview of the recent advances in the selective cyclohexene oxidation over heterogeneous transition metal‐based catalysts using environmentally benign oxidants like tert‐butyl hydroperoxide, H2O2 and molecular O2.