bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of biology and prospects of modern fishery for pacific herring Clupea pallasii on the shelf of southern Kuril Islands
Authors: Zolotov A. O. , Buslov A. V. , Ponomarev S. S.
Published: July 2022

Biological characteristics and dynamics of stocks and fishery are considered for pacific herring in the South-Kuril fishing district on the data of research surveys and fishery statistics for 2014–2021. Features of the herring wintering and the rates of linear growth and maturation are analyzed. The stock recovery on the shelf of southern Kuril Islands is detected that corresponds to recovery of the whole Sakhalin-Hokkaido population of this species. A sharp increase of the herring abundance in this area is observed nowadays for the first time since the 1940s. According to results of cohort modeling, the commercial biomass of herring in the South-Kuril district has increased from several tens of ton in 2014–2017 to 9,700 t in 2021. The basis of the stock consists of fish aged 3–4 years, 25–29 cm long, that prevailed (76–82 %) in the catches in 2020–2021. The stock increasing is accompanied by expansion of the herring distribution, the aggregations density increasing in spring, complication of the size and age structure, heightening of the average size and age in catches of fixed nets in the spawning season, mass appearance of the juveniles in catches of bottom trawl survey in 2020, and progressive growth of the landing in 2018–2021. The usual place for the herring wintering in this area is the eastern side of the deep-water canyon off the western coast of Kunashir Island. According to updated data, the spawning migrations of herring begin in early-middle April. The producers migrate mainly from the wintering sites to the southern Kunashir Strait, and then along the Pacific side of Kunashir Island to their spawning grounds. The migration along the Okhotsk Sea coast is secondary. The spawning occurs at Kunashir Island in the period from late April to middle May (the timing varies from year to year; the peak of spawning was observed in early May in 2020, but in middle May in 2021). Unlike other populations, the herring of the South-Kuril area do not make extended migrations after the spawning, but feed on adjacent shelf for a long time. Fishery on herring develops rapidly in the South-Kuril fishing district: the annual catch was 140 t in 2018, but reached 1010 t in 2021. Trawl fishery of pacific herring has the highest prospects for coming years. The fishing by Danish seines can be intensified in the waters between Kunashir and Shikotan in the pre-spawning period, though the landing by fixed nets on the spawning grounds can be stabilized if the number of coastal fishing teams will be increased.
Some aspects of biology and fishery of walleye pollock Theragra chalcogramma in the southwestern Chukchi Sea relative to the size and age structure
Authors: Buslov A. V. , Ovsyannikov E. E.
Published: July 2022

Catch distribution and size-age structure of walleye pollock in the Chukchi Sea are considered on the data obtained in surveys conducted by TINRO in 2018–2020. The age of pollock was determined by otoliths. Two age groups were presented in the catches: the first group of juveniles and 1-year old fish and the second group of 7–22-year old fish, mostly 8–15 years old (90 %). The fish of 3–6 year old were absent in the catches. This age structure suggests that the stock is formed by the fish migrated from the northern Bering Sea. However, the backward migration is doubtful; the pollock, once migrated to the Chukchi Sea, remain in this new habitat, as could be seen from the age-length dependence for a part of the stock distinguished by lower growth rate because of dwelling in severe conditions of this area. Aggregations of the fast-growing (just migrated from the Bering Sea) and slow-growing (local residents) pollock had different distribution patterns in the surveyed area in the southwestern Chukchi Sea. The fast-growing allochthonous pollock distributed widely, including the seaward waters, whereas the resident pollock preferred the coastal waters. The walleye pollock fishery has started in the southern coastal area of the Chukchi Sea in 2021, so the resident stock is exploited mainly.
Population dynamics of blue crab (Paralithodes platypus Brandt, 1849) in the northwestern Bering Sea
Authors: Fedotov P. A. , Chernienko I. S.
Published: July 2022

State of the blue crab stock and production is considered for the Russian sector of the Bering Sea on the data of bottom trawl and trap surveys conducted by TINRO in 2005–2017 and fishery statistics. The commercial stock was assessed for 2018 by cohort analysis. The absolute majority of commercial males within the West Bering Sea fishing zone concentrated in two areas located at Koryak coast and at Cape Navarin, whereas the commercial aggregations were absent in the Olyutorsky Bay and Karaginsky Bay. The stock distribution between these two areas was unstable; recently the aggregation at Koryak coast increased to 72 % of the total number of commercial males in 2017. This dynamics is conditioned by both changes in reproduction and intensity of fishery. The total commercial stock of blue crab had increased since 2014 and reached the maximum of 18.133 × 106 ind. (males) in 2017 that exceeded significantly the level of 2005–2013. The blue crab fishery extends in the Bering Sea, since 2010 the portion of used TAC increased from approximately 93 % in 2011–2015 to 98 % in 2016–2017 and 99 % in 2018. State of the population is evaluated as satisfactory and stable.
Dynamics of abundance and intrapopulation structure of pink salmon at the western and northeastern coasts of Kamchatka
Authors: Shevlyakov E. A. , Dederer N. A.
Published: July 2022

Interannual changes of the pink salmon abundance at the western and northeastern coasts of Kamchatka are analyzed. Local stocks with certain patterns of the abundance dynamics are revealed. Contribution of these local groups to the overall reproduction of the regional macro-complexes and catch of pink salmon in the 1957–2020 is considered. Prospects of the reproduction and catch are evaluated. Taking into account the revealed heterogeneity of the population dynamics in spatially isolated groups within macro-complexes, quality of forecasting the pink salmon stocks and catches at Kamchatka could be improved.
Fleet operations at fishing of japanese sardine and chub mackerel in the Kuril waters in the modern period of high abundance of these species
Authors: Kruchinin O. N. , Mizyurkin M. A. , Zakharov E. A. , Volotov V. M. , Shabelsky D. L. , Vakker N. L.
Published: July 2022

Chub mackerel and japanese sardine fishery is overviweved for the period since 1976. Two blooms of high abundance were observed within this period for both species. Effectiveness of fishing methods used during the past and the present blooms is compared to reveal prospects for their improvement and to sunstantiate the operating parameters of fishing gear suitable for energy capabilities of fishing vessels with certain tonnage. On results of this analysis, wider use of purse seine is recommended for landing of japanese sardine, as the more effective and resource-saving technology. The fish could be poured from the seine by either coupler or fish pump; the fish pump is recommended for trawl vessels, as well.
Assessment of the stock status for greenland halibut (Reinhardtius hippoglossoides matsuurae) in the Okhotsk Sea
Authors: Kulik V. V. , Glebov I. I. , Aseeva N. L. , Novikov R. N.
Published: July 2022

State of the greenland halibut stock in the Sea of Okhotsk fishing zone is evaluated as overfished with a high probability of 97.5 % by the index of fishable biomass, and the overfishing continued in 2021. This conclusion is based on results of double filtering the posterior parameter estimates in the state-space generalized surplus production model JABBA (Just Another Bayesian Biomass Assessment), with additional tuning of the new model taking into account these results. The overfishing was not caused by significant changes of environmental parameters (average SST and EOF modes of SST were examined), but its main reason was the overestimated target harvest rate established for the Far East of Russia as 10 % of the total biomass or a half of natural annual mortality (20 %). This incorrect value of the rate was based on incorrect determination of age structure and terminal age for the halibut by the fish scale method. The new approach of the stock status evaluation with JABBA model is independent on the age data. It includes the additional filtering of the JABBA model result, its refinement with stringent tuning using the algorithm of No-U-Turn sampler, and checking additional parameters on hyperstability or hypersensitivity. The new reference point of the target harvest rate is between 2.5 and 5.4 % (95 % credible interval) of the total biomass, with a median of about 3.75 %. This new value is slightly higher than that one used by ICES for greenland halibut in the northeastern Atlantic (3.5 % for fishable biomass, its reduction to 2.5 % is discussed), but these values cannot be compared because of different habitat conditions and probably different growth rate of greenland halibut in the Okhotsk Sea and the Atlantic. Researches on the optimal level of greenland halibut exploitation should be continued; anyway, the new reference point of the target harvest rate has to be implemented immediately and to be used at least until correction of the age-length key for greenland halibut in the Okhotsk Sea. The input data and Stan code of the new model are presented in the annexes.
Dekonstruksi Antologi Puisi Sori Gustri Karya Darmanto Jatman
Authors: Zuliana Rina
Published: July 2022

This paper discussed the deconstruction of linguistic structures, forms, and contents in an antology of Sori Gusti's poems by Darmanto Jatman. The aim was to reveal the things behind the form and content of Sori Gusti's poetry text by using the strategy of reading Derrida's Deconstruction. The use of multilinguality in the text to decentering in the use of the concept of language, between local languages and foreign languages, as well as between other language opposition. The reversal and obscurity of the opposition of the language led to the reconciliation of culture represented in the text as a form of diversity. In terms of typography poetry, negation or obscurity of the center (decentering) through the use of the form of speech spoken by “aku lirik” as an inferior voice. At conventions generally speeches had a vertical concept, the speech of the leader to his people, then obscured by a horizontal concept (equivalent line). The vertical-horizontal conception was then formulated to reveal the political content behind the text, neo-imperialism of Orde Baru regim. AbstrakTulisan ini membahas dekonstruksi struktur linguistik, bentuk, dan isi dalam kumpulan puisi Sori Gusti karya Darmanto Jatman. Tujuannya untuk mengungkap hal ihwal di balik bentuk dan isi teks puisi Sori Gusti dengan menggunakan strategi pembacaan Dekonstruksi Derrida. Pemanfaatan  multilingualitas dalam teks untuk meniadakan pusat (decentering) dalam penggunaan konsep bahasa, baik antara bahasa lokal dengan bahasa asing, maupun antaroposisi bahasa lainnya. Pembalikan dan pengaburan oposisi bahasa tersebut  mengarah pada pendamaian budaya yang terepresentasi dalam teks sebagai bentuk keberagaman. Dari segi tipografi puisi dan peniadaan atau pengaburan pusat (decentering) melalui penggunaan bentuk pidato yang dituturkan oleh aku lirik sebagai suara inferior . Pada konvensi umumnya pidato memiliki konsep vertikal, tuturan pemimpin kepada rakyatnya, kemudian dikaburkan dengan konsep horisontal (garis setara).  Konsepsi vertikal-horisontal kemudian diformulasikan untuk mengungkap muatan politis di balik teks, yakni neoimperialisme Orde Baru.
Local Wisdom and Didactic Values in Lullaby Kawih Mepende Murangkalih
Authors: Taufik Indra Nugraha
Published: July 2022

This research is entitled "Local Wisdom and Didactic Values in Lullaby Kawih Mepende Murangkalih Song". This study aims to examine the lullaby oral tradition in Bandung Regency. In this study, the author tries to record the lullaby that develops in the community. The area that is used as a source of lullabies is the Bandung Regency area. This research method uses descriptive qualitative. The focus is on a comprehensive picture of people's knowledge, skills, and attitudes towards lullabies in the Bandung Regency. The role of the lullaby is essential because it is part of the formation of the nation's character. Through local wisdom and didactic values in the lullaby, the message is expected to form toddlers, young people who have noble character when they grow up. AbstrakPenelitian ini berjudul “Kearifan Lokal dan Nilai-Nilai Didaktik dalam Lagu Lullaby Kawih Mepende Murangkalih”. Penelitian ini bertujuan mengkaji tradisi lisan lullaby di Kabupaten Bandung. Dalam penelitian ini, penulis mencoba merekam lullaby yang berkembang di masyarakat. Daerah yang dijadikan sumber lullaby adalah Wilayah Kabupaten Bandung. Metode penelitian ini menggunakan deskriptif kualitatif. Fokusnya adalah pada gambaran yang komprehensif tentang pengetahuan, keterampilan, dan sikap masyarakat terhadap lagu pengantar tidur di Kabupaten Bandung. Peran lullaby sangat diperlukan karena bagian dari pembentukan karakter bangsa. Melalui kearifan lokal dan nilai-nilai didaktis dalam lullaby, pesan tersebut diharapkan dapat membentuk balita, generasi muda yang berakhlak mulia ketika dewasa nanti.
Adverb in Indonesian
Authors: Wijana I Dewa Putu
Published: July 2022

This paper is intended to describe the forms and meanings of adverb in Indonesian. Adverbs are “words” that function to specify or locate the proposition expressed within the clause. By this concept, I limit my attention to merely what the so called “extra clausal adverbs”, a categorical concept along with noun, adjective, verb, etc. This concept is fundamentally differentiated from “adverbials”, elements of  clause structure along with subject, predicate, object, etc. By using data collected through introspective methods and some extracted from Intisari, and after analyzing them using distributional analysis followed by its continuation techniques (permutation, paraphrase, and comparison), the reasearch found that Indonesian adverbs are formally constructed at least by four kinds of morphological process, i.e. conversion, affixation, reduplication, and compounding. As far as the semantic roles are concerned, they can mainly be classified into four types, i.e adverbs of manner and state, adverbs of modality, adverbs  of frequency and quantity, adverbs of time. Finally, the differences that hold among Indonesian adverbs belong to the same semantic types might be related to  degree of formality, intensity, politeness, and style of the utturances. AbstrakMakalah ini bertujuan untuk memerikan bentuk dan makna adverbia dalam bahasa Indonesia. Adverbia adalah kata-kata yang berfungsi untuk mengkhususkan atau melokasikan proposisi yang diungkapkan oleh sebuah klausa. Dengan konsep ini, penulis membatasi perhatian pada apa yang selama ini disebut adverbia ekstra klausal, konsep kategori yang sepadan dengan nomina, adjektiva, verba, dsb. Konsep ini secara fundamental dibedakan dengan adverbial, elemen struktur  klausa yang sepadan dengan subjek, predikat, objek, dsb. Dengan data yang dikumpulkan melalui metode introspektif dan beberapa di antaranya dikumpulkan dari Majalah Intisari, dan setelah menganalisisnya dengan metode distribusional disertai dengan teknik lanjutannya (permutasi, parafrase, dan perbandingan), penelitian menemukan bahwa adverbia bahasa Indonesia sekurang-kurangnya dikonstruksi secara formal dengan proses konversi, afiksasi, reduplikasi, dan pemajemukan. Sementara itu berdasarkan peran semantisnya adverbia bahasa Indonesia dapat dibedakan menjadi adverbia cara dan keadaan, modalitas, keseringan dan kuantitas, dan waktu. Akhirnya adverbia-adverbia yang tergolong ke dalam tipe semantik yang sama memiliki perbedaan dalam hal tingkat keformalan, intensitas, kesantunan, dan ragam tuturan.
ANÁLISE DAS PRÁTICAS PEDAGÓGICAS DOS PROFESSORES NO ENSINO REMOTO EMERGENCIAL DE DUAS ESCOLAS PÚBLICAS DE RORAIMA
Authors: Oliveira Jesucina do Nascimento Moura , Cunha Roseane Parente , Castro Patrícia Macedo de , Fioretti Elena Campo
Published: July 2022

A decretação da pandemia da Covid-19 promoveu um cenário de incertezas em diferentes áreas da  vida humana, entre estas a educacional. Em virtude deste cenário, este trabalho teve como objetivo, investigar o desenvolvimento da prática pedagógica e o processo de adequação dos professores ao Ensino Remoto Emergencial com o uso das tecnologias como instrumento mediador no processo de ensino aprendizagem dos alunos. Como embasamento teórico, foram utilizadas publicações que tratam da questão do enfrentamento da pandemia no contexto educacional em meio aos desafios do Ensino Remoto Emergencial. Os procedimentos metodológicos, deste estudo contemplam uma abordagem qualitativa de objetivo exploratório, em que utilizou-se, um questionário com 11 perguntas abertas via Google Forms, aplicado com oito professores de duas escolas públicas de Roraima, visando identificar a realidade em dois contextos diferentes, quatro dos professores atuam na capital Boa Vista e quatro no município de Alto Alegre à 87 km da capital. Os resultados evidenciam que tanto os professores da capital quanto do interior em sua maioria, tiveram que se adequar para o ensino remoto e sentem insegurança e despreparo frente ao uso dos meios tecnológicos, necessitando de formação continuada com esta finalidade, e mesmo com um cenário de adaptações, sentem-se frustrados e cansados. Contudo, mostram a importância de um olhar diferenciado para o cenário pós pandemia no que diz respeito as novas formas de ensino, assim como uma autorreflexão de que precisam de maior preparação frente ao conhecimento e uso dos meios tecnológicos.
Investigating Systemic Immune Biomarkers in a Controlled Human Hookworm Infection Model
Authors:   , Mamum John
Published: July 2022

The alarming rise in the prevalence of chronic inflammatory conditions in developed countries has recently been proposed to be associated with the disappearance of helminth infections. It’s hypothesised that helminths such as hookworms can regulate the immune system via their release of excretory-secretory products to suppress inflammatory immune responses. This has led to the concept of hookworm therapy for the treatment of chronic inflammatory disorders such as multiple sclerosis and inflammatory bowel disease. However, to date, there has not been sufficient longitudinal immunological data in healthy humans infected with hookworm. This thesis aimed to characterise key serum immune biomarkers elicited in a controlled human hookworm infection model phase I longitudinal clinical study. Thirteen healthy participants were administered 30 infective L3 N. americanus larvae and followed across 48 weeks. Serum immunoassays were performed to assess a broad range of biomarkers including immunoglobulins, cytokines, and chemokines in participants at baseline and following N. americanus infection. These results were analysed alongside other cellular, symptomatic, and physiological parameters performed to assess safety/tolerability and patency following N. americanus infection.

The clinical study demonstrated that patency was established from week 8 onwards following N. americanus infection and there were no severe symptoms reported however one participant was dewormed at week 6 post- infection (p.i.) due to gastrointestinal discomfort. The findings outlined in this thesis revealed that total IgE levels were elevated from week 8 onwards however total IgA, IgM, IgG1, IgG2, IgG3, and IgG4 were relatively stable following N. americanus infection. Antigen-specific IgG responses were markedly elevated from week 8 to week 48 p.i. Elevations in total IgE and antigen-specific IgG responses coincided with the establishment of patency. There was a dramatic spike in serum IL-5 levels at week 4 following N. americanus infection. However, the remaining serum cytokines and chemokines did not significantly increase in most participants over the course of the infection. Furthermore, a positive correlation was determined between serum IL-5 levels and whole blood eosinophil counts which peaked at week 8 following infection. Taken together, this data suggests that infection with 30 infective L3 N. americanus larvae was safe and tolerated in healthy participants. Additionally, IgE, antigen-specific IgG, IL-5 and eosinophil responses were elicited systemically during N. americanus infection, suggesting a dominant Th2 response. This offers insights into the potential immune mechanistic pathways implicated in human hookworm infection.
Nonspecific Reactive Hepatitis – Unknown or Forgotten Diagnosis? (Short Review and Invitation to Discussion)
Authors:   Ukrainian Military Medical Academy, 45, Gen. Almazova St., Kyiv 01010, Ukraine, Boichak M. P. , Fedorova O. O. ,   Ukrainian Military Medical Academy, 45, Gen. Almazova St., Kyiv 01010, Ukraine, Illyashenko Yu. M. ,   Military Medical Clinical Center of the Northern Region, 5, Kultury Str., Kharkiv 61000, Ukraine, Zhurko M. M. ,   Ukrainian Military Medical Academy, 45, Gen. Almazova St., Kyiv 01010, Ukraine, Antonov A. B. ,   Military Medical Clinical Center of the Northern Region, 5, Kultury Str., Kharkiv 61000, Ukraine
Published: July 2022

The purpose of the study was to analyze and summarize information from the sources of scientific literature on nonspecific reactive hepatitis. Materials and methods. Analytical and bibliosemantic methods were used in the study. The search was performed in Google Scholar, NCBI, PUBMED and Web of Science databases using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) recommendations. Results and discussion. Acute and chronic liver diseases rank as one of the leading places in the structure of pathology of internal organs. The consequence of these diseases in many cases is the development of cirrhosis of the liver, which ranks 11th among the leading causes of death and 15th among the causes of morbidity in the world. Among hepatopathies, nonspecific reactive hepatitis (code K75.2 for ICD-10; DB97 for ICD-11) is rarely mentioned and diagnosed – secondary hepatitis caused by several endogenous and exogenous factors that reflect the liver's response to any somatic disease. There are few publications on this problem, but there are many publications on the deviation of liver function tests: bilirubin, alanine and aspartate aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase in many pathological conditions, including in critically ill patients regardless of their trauma, cardiac and acute surgical pathology, intestinal disorders. Frequent signs of hepatic dysfunction in many diseases, along with a small number of clinical diagnoses of nonspecific reactive hepatitis, indicate a problem of underdiagnosis, which can be explained by the lack of clear clinical, laboratory and instrumental signs of this disease. Determination of biomarkers of the liver function used in routine clinical practice requires qualitative and quantitative clarification, ultrasound is not always informative, and computed tomography is not always available. This indicates the urgency of the problem of defining the concept and criteria for the diagnosis of nonspecific reactive hepatitis and the need for large-scale clinical studies, especially in critical conditions of various etiologies, in the pathogenesis of which are hemodynamic disorders and systemic inflammatory response. Conclusion. The low diagnosis of nonspecific reactive hepatitis can be explained not only by the ignorance of doctors, but also by the lack of clear diagnostic criteria. The true prevalence of nonspecific reactive hepatitis does not correspond to the frequency of pathology in clinical diagnoses
Acute Hepatitis of Unknown Etiology: the Task of Epidemiological Surveillance in Ukraine in Modern Conditions
Authors:   Kharkiv National Medical University, Epidemiology Department. 4, Nauky Ave., Kharkiv 61022, Ukraine, Railian M. V. , Chumachenko T. O. , Makarova V. I. , Semishev V. I.
Published: July 2022

The purpose of the study was to analyze cases of acute hepatitis of undetermined etiology and define the main problems and tasks of epidemiological surveillance in Ukraine for emergent disease of acute hepatitis of unknown etiology. Materials and methods. The method of retrospective epidemiological analysis of data from open sourses on cases of acute hepatitis of undetermined etiology and the bibliosemantic method were used. Results and discussion. It was found that from April 5 to May 27, 2022, 650 cases of acute hepatitis of undetermined etiology in children were registered in 33 countries in 5 World Health Organization regions. The majority of reported cases, 58%, are in the World Health Organization European Region (22 countries). According to data as of May 31, 2022, we realized that the highest incidence of acute hepatitis of unknown etiology among children under 16 years old was observed in countries such as Great Britain – 50.8%, Spain – 11%, Italy – 9.5%, Portugal – 4.9%, the Netherlands and Belgium – 4.6% each, Austria and Cyprus – 0.7% each, Denmark – 2.3%, Greece and Norway – 1.6% each, and Ireland – 2.6%. Out of 305 patients with acute hepatitis of unknown etiology, 237 people were hospitalized, which is 77.7% of cases. Most of them were hospitalized in the UK – 65% of patients, Italy – 11% of cases, Spain – 8.0% of patients. In total, 7.5% of patients were in intensive care units, the largest number was in the UK – 60.9% of cases, Ireland and Spain – 13% of patients. In the age and sex structure of the diseased, children aged 5 years and younger (76%) and female persons prevailed. The etiology is unknown, but there is an association of cases with adenovirus type 41. Samples of whole blood, serum, urine, feces, airway washes, and, if possible, liver biopsies were examined in sick children under 16 years old. A total of 199 cases of acute hepatitis of unknown etiology were tested for adenovirus, of which 59.3% were positive. PCR testing for SARS-CoV-2 was performed in 204 patients, and 11.8% of patients had positive results. Serological tests for SARS-CoV-2 samples of 34 patients were positive, 67.6% of samples. Vaccination against COVID-19 was reported in 72 patients with acute hepatitis of unknown etiology, of which 61 patients (85%) were not vaccinated. Conclusion. It is indicated that it is necessary to identify possible cases of acute hepatitis of undetermined etiology, implement epidemiological investigation of each case, inform medical workers and exchange information with specialists, practice educational work among the population
Pecularities of the Pancreatitis Development on the Background of Some Rheumatic Diseases
Authors:   Bukovinian State Medical University, Internal medicine Department. 79b, Horikhivska St., Chernivtsi 58004, Ukraine, Teleki Ya. M. , Khrystych T. M. , Olinik O. Yu. , Ibragimov E. Yu. , Gorodinsky S. I.
Published: July 2022

The purpose of the study was to evaluate the main pathogenetic mechanisms of pancreatic lesions on the background of systemic connective tissue diseases based on the analytical analysis of modern literature data. Materials and methods. Bibliosemantic and analytical methods were used in the research. Results and discussion. The main pathogenetic link of the pancreatitis development in patients with systemic connective tissue diseases is vasculitis of the pancreas. Increased expression of adhesion molecules with activation of leukocytes and endothelial cells, deposition of circulating immune complexes in the vascular wall, production of antibodies to endothelial cells, capillary basement membranes play an important role in this process. In systemic lupus erythematosus, according to various authors, the frequency of arteritis varies greatly: rates range from 6.2-7.4 to 53%. In rheumatoid arthritis, the frequency of arteritis of the pancreatic vessels reaches 50%, in systemic sclerosis – 17%. Secondary Sjogren's syndrome is associated with autoimmune pancreatitis in a quarter of cases, but is not the cause. In diseases such as rheumatoid arthritis, systemic scleroderma and systemic lupus erythematosus, antibodies that can attack phospholipids of cell membranes are produced. Antiphospholipid syndrome develops often in systemic lupus erythematosus (70% of cases). In rheumatic fever patients’ changes in the pancreas were studied only in single studies. The main mechanism of pathogenesis of both acute and chronic pancreatitis in nodular periarteritis is the involvement of small and medium arteries of the pancreas in the pathological process. In granulomatous polyangiitis in the pancreas reveals vascular-granulomatous changes, resulting in the formation of extravasations, necrotic foci, foci of atrophy, sclerosis. In IgA vasculitis, changes in the structure of the pancreas are minimal or there are isolated small subcapsular hemorrhages. It is established that metabolic disorders occur in many rheumatic diseases. Thus, reduced glucose tolerance is observed in 7–74% of patients, hypercholesterolemia and triglyceridemia – in 50–75%, hypertension – in 25–50% of cases. Conclusion. Thus, the diagnostic approach to the pancreatitis in systemic connective tissue diseases is very difficult. Its manifestations are masked by damage of the other organs. The availability of more sensitive diagnostic methods, their accessibility can provide an opportunity to detect symptoms of pancreatitis earlier, which will contribute to the appointment of optimal treatment, improvement of the prognosis, quality of life and survival of such patients
Features of the Expression of the Cell Adhesion Molecule E-Cadherin in Different Molecular Subtypes of Invasive Ductal Breast Cancer
Authors:   Danylo Halytsky Lviv National Medical University. 69, Pekarska Str., Lviv 79010, Ukraine, Volos L. I. , Dudash A. P. ,   Danylo Halytsky Lviv National Medical University. 69, Pekarska Str., Lviv 79010, Ukraine,   Western Ukrainian Histological Laboratory. build 38, 77, Heroiv UPA Street, Lviv 79015, Ukraine
Published: July 2022

The purpose of the study was to determine the role of E-cadherin in the development and progression of molecular subtypes of invasive ductal breast cancer by assessing the expression of E-cadherin in various clinical and pathological prognostic parameters. Materials and methods. We demonstrated a comprehensive morphological, including immunohistochemical study of 193 cases of invasive ductal breast cancer with the molecular phenotype definition. General histological processing of samples was performed according to standard methods. Immunohistochemical studies for E-cadherin, ER, PR, c-erbB2, Ki-67 were performed according to standardized analytically validated protocols with the necessary controls. The grade of malignancy was determined according to the modified scheme of P. Scarff, H. Bloom and W. Richardson. E-cadherin expression level was quantified in 86 observations using the Qureshi counting system. Comparison of E-cadherin expression in different clinical and pathological parameters was evaluated using Pearson's test χ2. For all types of analysis, differences were considered significant at p <0.05. Results and discussion. E-cadherin expression in ductal breast cancer tissue is significantly lower in cases with lymph node metastases than without metastatic lymph node involvement (χ2 = 4.55, p = 0.031). Low expression of E-cadherin or its absence was associated with pT3 tumors, clinical stage 3, with G2 and G3 malignancies. Loss of E-cadherin expression has an unfavorable prognostic value. E-cadherin expression is associated with the molecular type of invasive breast ductal carcinoma. High E-cadherin expression was common in ER-positive tumors of the luminal A phenotype and was determined in patients of both premenopausal and postmenopausal age, suggesting that ER-positive expression may be involved in the regulation of E-cadherin expression. Low tumor activity of cells of invasive ductal breast cancer of the luminal subtype is accompanied by an increase in the adhesive properties of these cells due to the high level of expression of E-cadherin. E-cadherin is considered an independent marker of triple-negative breast cancer and is characterized by an unfavorable prognosis and short life expectancy. Triple-negative cancer was associated with a significant predominance of patients with low and negative E-cadherin expression (p = 0.011). Conclusion. Thus, E-cadherin is a potent tumor suppressor of breast cancer. According to this role in the progression of breast cancer, it was found that partial or complete loss of E-cadherin expression correlates with an unfavorable prognosis in patients
The Role of Sympathetic Trunks in the Innervation of the Posterior Mediastinum Blood Vessels in Human Fetuses
Authors:   Bukovinian State Medical University, Human Anatomy Department. 2, Hadyatska St., apt. 2, Chernivtsi 58006, Ukraine, Stelmakh G. Ya.
Published: July 2022

The purpose of the study was to establish patterns of variation of the branches of the right and left sympathetic trunks in the thoracic aorta azygos and hemiazygos veins during the fetal period of human ontogenesis. Materials and methods. An anatomical study was performed on 47 human fetuses using macromicroscopic preparation of neurovascular branches under the control of binocular magnifier, vascular injection, application contrasting of prepared vessels and nerves, making 3D reconstruction models of the posterior mediastinum structures and morphometry. Results. The anatomical variability of nodes and branches of the thoracic right and left sympathetic trunks involved in the innervation of the thoracic aorta, azygos and hemiazygos veins has been established in the human fetuses of different age groups. The segmental-metameric distribution of the visceral branches of the thoracic sympathetic trunk was revealed, as well as the preservation of the segmental sympathetic innervation of the thoracic aorta, azygos and hemiazygos veins both on the left and on the right. Despite the significant progress in the study of morphological features of innervation of posterior mediastinum organs and structures, the active development of fetal surgery in recent years raises a number of questions related to the sources of sympathetic innervation of the thoracic aorta, azygos and hemiazygos veins. Conclusion. The sources of innervation of the thoracic aorta, azygos and hemiazygos veins in human fetuses are: thoracic nodes and internodal branches of the right and left sympathetic trunks; large visceral nerves; branches of the esophageal, pulmonary and cardiac plexuses; vagosympathetic trunks; collateral trunk. The number of branches to the thoracic aorta from the left sympathetic trunk is 4-16, and from the right sympathetic trunk – 3-14. The largest number of branches that enter the wall of the thoracic aorta, from the left sympathetic trunk skeletotopically determined at the level of III-VI thoracic segments, and from the right sympathetic trunk – at the level of IV-VI thoracic segments. Different skeletotopic levels of the branches of the right and left large visceral nerves are involved in the innervation of the thoracic aorta – from V to X thoracic segments. It is noted that the right and left sympathetic trunks are almost equally involved in the innervation of the azygos and hemiazygos veins. The number of sympathetic branches to the azygos vein ranges from 4 to 7, and the number of sympathetic branches to the hemiazygos vein is usually 2-4
HUBUNGAN KEPATUHAN MASYARAKAT TERHADAP PROTOKOLER COVID DENGAN KEJADIAN COVID DI DESA PAYUNG KECAMATAN WELERI
Authors: Sulastri Sulastri , Sonyo Rini Sri Hesthi
Published: July 2022

Coronavirus Disease 2019 (Covid-19) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). SARS-CoV-2 merupakan coronavirus jenis baru yang belum pernah diidentifikasi sebelumnya pada manusia. Ada setidaknya dua jenis coronavirus yang diketahui menyebabkan penyakit yang menimbulkan gejala beratseperti Middle East Respiratory Syndrome (MERS) dan Severe Acute Respiratory Syndrome (SARS). Tanda dan gejala umum infeksi Covid-19 antara lain gejala gangguan pernafasan akut seperti demam, batuk dan sesak napas. Masa inkubasi rata-rata 5-6 hari dengan masa inkubasi terpanjang 14 hari. Pada kasus Covid-19 yang berat dapat menyebabkan pneumonia, sindrom pernafasan akut, gagal ginjal, dan bahkan kematian. Penelitian ini bertujuan untuk mengetahui hubungan kepatuhan masyarakat terhadap protokoler covid dengan kejadian covid di desa Payung Kecamatan Weleri. Metode penelitian kuantitatif. Teknik pengambilan sampel menggunakan Simple random sampling dengan sampel sebanyak 58 responden. Analisis statistic menggunakan chi square. Hasil didapatkan ada hubungan kepatuhan masyarakat terhadap protokoler covid dengan kejadian Covid-19 di desa Payung Kecamatan Weleri dengan nilai p value 0,000 (P<0,05).
VISUALISASI DAN ANALISIS DATA FASILITAS KESEHATAN BERBASIS WEB DENGAN ARCGIS STORYMAPS
Authors: Fikriyah Vidya Nahdhiyatul , Hasbi Habid Al , Anggani Nirma Lila , Kiat Umar El Izzudin
Published: July 2022

Kesehatan merupakan salah satu aspek yang penting bagi kehidupan. Hingga saat ini, penyampaian data terkait kesehatan umumnya terbatas dalam bentuk tabel, grafik, dan deskripsi. Oleh karena itu perlu adanya inovasi untuk menampilkan data kesehatan secara lebih menarik, efektif, dan membagikannya secara lebih luas. Tujuan dari penelitian ini adalah (1) mevisualisasikan data fasilitas kesehatan dengan media web, dan (2) menganalisis ketersediaan fasilitas kesehatan di Boyolali. Data bersumber dari profil kesehatan Boyolali tahun 2020. Tampilan data fasilitas kesehatan dilakukan menggunakan fitur yang ada di aplikasi ArcGIS StoryMaps, sedangkan analisis ketersediaan fasilitas dilakukan secara kualitatif dengan pendekatan spasial. Dari data yang digunakan, dihasilkan tampilan web (https://arcg.is/1mC1z50) berisi grafik dan empat peta untuk sebaran rumah sakit, sebaran puskesmas, keterjangkauan fasilitas, dan sebaran kasus Covid-19. Analisis menunjukkan bahwa fasilitas kesehatan lebih banyak berada di Kecamatan Boyolali dengan keterjangkauan fasilitas yang masih kurang di wilayah barat dan utara Kabupaten Boyolali. Hasil ini diharapkan dapat membantu pemerintah lokal dalam merencanakan pembangunan fasilitas kesehatannya.
EFEKTIVITAS PEMBERIAN KASTENGEL BEKATUL SITUBAGENDIT DAN IR64 TERHADAP KADAR GULA DARAH PENDERITA DIABETES MELLITUS NON INSULIN
Authors: Luthfianto Dodik , Noviyanti Retno Dewi , Kurniawati Indah
Published: July 2022

Diabetes Mellitus merupakan  penyakit metabolik dengan karakteristik hiperglikemia. Pengelolaan Diabetes mellitus  memerlukan penanganan multidisiplin yang mencakup terapi non-obat dan terapi obat. Salah satu terapi non-obat dengan  diet tinggi serat. Bekatul merupakan jenis bahan pangan yang memiliki kandungan serat tinggi diantaranya bekatul varietas Situbagendit dan IR 64. Tujuan : penelitian untuk menganalisis efektivitas pemberian  kastengel bekatul Situbagendit dan IR 64 terhadap penurunan  kadar GDS pasien diabetes mellitus  non insulin. Metode : Penelitian menggunakan desain  experimental randomized pretest-postest control group design. Sampel dalam penelitian  penderita diabetes mellitus non insulin. . Hasil penelitian pada kelompok kastengel situbagendit kadar GDS sebelum intervensi adalah 264.70±130.295 dan setelah intervensi adalah 192.90±91.567 dengan nilai  p = 0.015. Pada kelompok kastengel IR64 kadar GDS sebelum intervensi adalah 242.00±110.089 setelah intervensi adalah 187.80±119.550 dengan nilai  p = 0.013.  Ada perbedaan kadar GDS sebelum dan sesudah  intervensi  pemberian kastengel varietas Situbagendit dan IR6 pada masing-masing kelompok. Perbedaan antar kelompok diperoleh nilai  sebelum  intervensi  (p = 0.679) dan setelah intervensi (p = 0.762). Ada perbedaan kadar GDS sebelum dan sesudah intervensi pada kelompok kastengel situbagendit. Ada perbedaan kadar GDS sebelum dan sesudah intervensi pada kelompok kastengel IR64. Tidak ada perbedaan kadar antara kelompok  kastengel Situbagendit dan IR64 setelah intervensi. Pemberian kastengel bekatul varietas IR64 lebih efektif  dibandingkan dengan kastengel bekatul varietas Situbagendit berdasarkan penurunan kadar GDS.
STRATEGI KOPING KELUARGA TERHADAP KEKAMBUHAN PASIEN GANGGUAN JIWA DENGAN PERILAKU KEKERASAN
Authors: Sumarsih Tri , Sulistya Candra , Widiyanto Basuki
Published: July 2022

Salah satu manifestasi dari gangguan jiwa yang menjadi penyebab penderita dibawa ke rumah sakit adalah perilaku kekerasan. Individu dengan perilaku kekerasan membutuhkan strategi koping keluarga yang tepat agar mampu menurunkan tingkat kekambuhan sakitnya. Penelitian ini bertujuan untuk mengetahui hubungan antara strategi koping keluarga dengan kekambuhan pasien perilaku kekerasan di poliklinik jiwa Rumah Sakit Panti Waluyo Kabupaten Purworejo. Penelitian ini menggunakan metode deskriptif korelasi. Jumlah sampel sebanyak 187 diambil melalui teknik purposive sampling. Strategi koping keluarga diukur menggunakan kuisioner Ways of Coping. Sedangkan pengukuran kekambuhan dilakukan menggunakan kuesioner kejadian kekambuhan perilaku kekerasan. Analisis data yang digunakan yaitu uji Chi Square. Hasil penelitian menunjukkan sebagian besar responden menggunakan strategi koping EFC (Emotion Focused Coping) dalam menangani pasien perilaku kekerasan sebanyak 110 responden (58,8%). Sebagian besar pasien perilaku kekerasan tidak mengalami kekambuhan dalam 6 bulan terakhir sebanyak 136 responden (72,7%). Pengujian hipotesis menunjukkan ada hubungan strategi koping keluarga terhadap kejadian kekambuhan pasien perilaku kekerasan di poliklinik jiwa RS Panti Waluyo Purworejo dibuktikan dari hasil uji chi square diperoleh (p-value =0,005 <0,05). Kata kunci: strategi koping, keluarga, kekambuhan, perilaku kekerasan
Volumetric Soft Tissue Changes After Using Injectable Platelet-Rich Fibrin (I-PRF) Versus Subepithelial Connective Tissue Graft in Interdental Papillae Defects: A Randomized Controlled Clinical Study
Authors: Bissar Mohamed Wagdy , Nasser Nouran , El-Mofty Mohamed Sherif
Published: July 2022

Background: Lost interdental papillae in the esthetic region are of great concern from the esthetic and functional point of view. We elicit a clinical study of papillary reconstruction in this article using injectable platelet-rich fibrin (I-PRF) as a nonsurgical procedure and compare its results to those of the subepithelial connective tissue graft (SECTG), being considered the gold standard method used to reconstruct interdental papillae. Methods: Twenty-four patients seeking treatment for black triangles were randomized into two groups: group A patients were treated with the SECTG technique, and group B patients were treated with I-PRF. Four injections were given at each papilla site at baseline, two-, four-, and six-week intervals to ensure optimal esthetics. Pain, clinical, and volumetric assessments were done. Volumetric assessment was completed through intraoral scanning of the papilla site at baseline and after six months, after which the results were obtained by superimposition of both scans. Results: Group A (5.08 ±2.15) had a significantly higher mean pain score value than group B (1.17 ±0.94) (p < 0.001). Group B (0.31 ±0.21) had a higher mean value of volumetric changes at the interdental papillae than group A (0.25 ±0.17), yet the difference was not significant (p = 0.517). Conclusion: Injectable platelet-rich fibrin gave comparable results to SECTG in Nordland Class I defects only, provided that the injection protocol was once every 15 days for a two-month period. Patients treated with I-PRF were more satisfied with the procedure and the results than patients who were treated with SECTG.
PENGARUH INVESTASI, RISK BASED CAPITAL DAN KOMITE AUDIT TERHADAP KINERJA PERUSAHAAN (Studi pada Perusahaan Asuransi yang Terdaftar di Bursa Efek Indonesia)
Authors: Nurhayati Agustin , Ratna Ratna , Iswadi Iswadi
Published: July 2022

This study aims to analyze effect of investment, risk based capital and audit commitee on firm performance in Insurance Companies on Indonesian Stock Exchange during 2010-2020. The number of samples in this study are 9 Insurance Companies which are listed on the IDX and have completed data obtained by porpousive sampling method. The type of data used is secondary data in the form of panel data obtained from the company's Annual Report. The data analysis method used is Panel Data Regression. The results of this study find that investment has a positive and significant effect on firm performance, while risk based capital and audit commite have no significant effect firm performance.
PENGARUH BUDAYA KERJA, DUKUNGAN ORGANISASI DAN PROFESIONALISME TERHADAP PRODUKTIFITAS KERJA AUDITOR INSPEKTORAT DI PROVINSI ACEH
Authors: Verdinan Marthin , Qamarius Ibrahim , Mariyudi Mariyudi
Published: July 2022

This study examined the effect of Work Culture and Organizational Support on Auditor Professionalism and Work Productivity of Inspectorate Auditors in Aceh Province. This study used 126 auditors taken proportionally from 23 regencies and cities in Aceh Province. The analytical tool used was Structural Equation Modeling (SEM) using AMOS (Analysis of Moment Structure) tools. The results indicated that work culture did not influence professionalism of Auditors but significantly influenced the work productivity of Auditors. While the Organizational Support factor significantly influenced the Professionalism and Work Productivity of Auditors. Furthermore, Professionalism significantly influenced the work productivity of Auditors. Meanwhile, in the indirect relationship test, Professionalism did not mediate the relationship between Work Culture and Work Productivity of Auditors. However, Professionalism mediated the relationship between Organizational Support and Work Productivity of Inspectorate Auditors in Aceh Province
PENGARUH KONFLIK KERJA, KOMUNIKASI DAN STRESS KERJA TERHADAP KINERJA PEGAWAI DENGAN KEPUASAN KERJA SEBAGAI VARIABEL INTERVENING PADA DINAS PENDIDIKAN DAN KEBUDAYAAN KABUPATEN ACEH UTARA
Authors: Dharma Adi , Aiyub Aiyub , Qamarius Ibrahim
Published: July 2022

This study aims to (1) determine the effect of work conflict, communication and job stress on job satisfaction. (2) knowing work conflict, communication, job stress and job satisfaction on employee performance (3) knowing job satisfaction mediating the relationship between work conflict, communication and job stress on employee performance. The data used in this study is primary data as many as 139 respondents at the North District Education and Culture Office. The data analysis method in this study uses a structural equation model with the help of an analysis of moment structure. The results of the study found that work conflict and communication had a positive and significant effect on job satisfaction, while job stress had no effect on job satisfaction. Furthermore, communication and job satisfaction have a positive and significant effect on employee performance, while work stress has a negative and significant effect on employee performance, but work conflict has no effect on employee performance. Job satisfaction is able to mediate the relationship between work conflict and job satisfaction partially mediation, while job satisfaction is able to mediate the relationship between communication and job satisfaction in full mediation and job satisfaction is not able to mediate the relationship between job stress and job satisfaction