bluuebunny/crossref_metadata_2025 huggingface dataset:
Cognitive and Metacognitive Strategies in Problem-Posing Tasks in the Context of Science
Authors: YURTTAŞ KUMLU Gülfem Dilek , TAŞTEPE Mehtap
Published: October 2023

This study aims to determine the cognitive and metacognitive strategies used by pre-service mathematics teachers for activating mental processes in a semi-structured problem-posing task. A holistic multiple-case design was used to in this study. For the case study, five voluntary pre-service mathematics teachers participated in this study. This task involves problem-posing in the context of science appropriate for different mathematical expressions. A think-aloud protocol, a semi-structured interview, observation and the pieces of papers for each question were used in this study. Open coding was performed using the continuous comparative analysis technique. The main results are that (a) they used various cognitive and metacognitive strategies to activate mental processes in problem-posing, (b) these strategies differed both in diversity and the usage of frequency of them and some strategies are either domain-specific or general-specific and (c) the use of metacognitive strategies is more common than cognitive strategies.
The Importance of Investigating Students’ Lifelong Learning Levels and Perceptions of 21st-Century Skills
Authors: GÜNDÜZ Abdullah Yasin
Published: October 2023

Lifelong learning starts in childhood and youth, continuing throughout adulthood and old age. It encompasses formal learning in settings such as schools and training centers, informal and non-formal learning derived from colleagues and workplace trainers, and unintentional learning stemming from spontaneous social interactions. In today's fast-paced world, students need to acquire 21st-century skills and be lifelong learners. Therefore, it is crucial to understand the relationship between students’ perceptions of 21st-century skills and their effective lifelong learning levels. This research aims to investigate the following questions: “What are the students’ levels of success in lifelong learning and their perceptions of 21st-century skills? Is there a relationship between them?” and “Do students’ perceptions of 21st-century skills predict their levels of success in lifelong learning?”. The results indicated that students’ levels of success in lifelong learning and 21st-century skills have a strong correlation. Students have high characteristics that will enable effective lifelong learning, and their perceptions of 21st-century skills are moderate. In addition, students' perceptions of 21st-century skills predict their success levels in lifelong learning at a high rate.
Guidance Materials Enhanced with Digital Content to Understand the Characteristics of Birds and Student Opinions
Authors: NİZAM Mustafa , ÖNER ARMAĞAN Fulya
Published: October 2023

The purpose of this research is to develop guide materials on "Features of Birds", to apply the materials and to get students' opinions about the materials. The participants of the study consisted of 28 students studying in the 5th grade of a public secondary school in the 2022-2023 academic year. In the study, the development and application processes of the guide materials used are explain in detail. After the application, an interview form consisting of five questions was applied to 28 students in order to get the opinions of the students about the guide materials. Descriptive analysis was used to analyze the interviews. As a result of the research; It was determined that the guide materials enriched with digital contents increased the students' interest in the subjects, aroused curiosity, they learned by having fun, and they wanted similar applications in other subjects.
An Analysis of the Place of the History of Science in Chemistry Textbooks
Authors: ZERMAN KEPCEOĞLU Gülşah , İREZ Serhat
Published: October 2023

Many science educators have expressed the role and importance of the history of science in promoting scientific literacy. It is generally acknowledged that students should understand the social and cultural structure of science knowledge, in which students learn not only the concepts and principles offered by science but also the application areas of the information provided by science and the scientific knowledge they have created. From this point of view, the history of science emerges as a potential resource and a meaningful teaching strategy that can be used both in the teaching of scientific content and the nature of science. On the other hand, it is clear that textbooks are one of the essential components of science education, given their role in education. Textbooks are the primary source of information in the learning environment. It is the most important educational resource for students outside and beyond the teacher, and for the teacher, it is often the representative of the teaching program. Many teachers, especially novice teachers, construct the content and course of lessons according to the textbooks in their hands. From this point of view, this study investigates how much history of science is integrated in high school textbooks. For this purpose, appropriate textbooks (grades 9-12) taught by the Ministry of Education (MoNE) as a textbook in high school were examined. A qualitative research approach was followed in the study and document analysis was chosen as the study design. When each course book is examined, the sections containing the science history information are identified and taught carefully read. The quality of these sections in learning and teaching has been analyzed. Of the analyses, a scoring key was used, which allows scoring using a total of 13 criteria in conceptual, procedural, and contextual areas of the quality of science historical stories. As a result of the research, the history of science for conceptual, procedural, and contextual understanding has been included in high school chemistry textbooks, but this use is limited. While more importance is attached to scientific history for procedural understanding in books, it has been found that the use of the history of science is worthless for conceptual and contextual understanding.
Digitalization of Education: the Experience of France
Authors: Kulyk Olena
Published: October 2023

At the present stage of development of Ukraine’s education and science, the issue of digitalisation requires consideration and further research, and since European Union countries possess more solid achievements in the field of digitalisation of education, their experience is extremely useful for Ukraine. The author of this article considers it reasonable to focus on the experience of France. The research goal is analysing the experience of France in the aspect of digitalisation of education, generalising and finding a scientific rationale of present-day challenges of information society for all stages of continuing education. Methods. In the course of the research, general scientific methods were used (analysis, synthesis, induction, deduction, comparison, generalisation), which enabled us to perform a complex and systemic analysis, consider and summarize developments of prospective best practices of digitalisation of education in France. The results. Basing on examination of specific facts and phenomena in digitalisation of education, the author has singled out the most important associations that provide opportunities for remote learning in France and offer a variety of courses – commercial, free of charge and mixed, permanently available or available for a certain period of time according to the curriculum, designed for laymen and specialists, unlimited and limited (with limitations as to the number of participants), with support or without it, with participation of an expert/several experts, or developed by amateurs. Conclusions. France has been introducing remote learning since 1996. Over time, the transition to digital education has proven the ability of France’s education system to adapt to new conditions, and the ability of its higher education institutions to defend and ensure importance of their activities ‒ universities did not disappear but instead, they created the background for introduction of remote learning and further development of informatization in education. Meanwhile, the many years’ experience has shown that much has been done, but even more remains to be accomplished to ensure effectiveness and quality of digitalisation of education. This is evidenced, among other factors, by activities of Digital Estates General, which has developed (in cooperation with the entire educational community) 40 proposals concerning digitalisation strategies. Hence, the work in this direction never stops but continues to be implemented in a newer version that takes into account previous mistakes and corrects them.
Development of Innovative Approaches to the Popularization of Science and Technology for the Development of Interaction Between Science and Society
Authors: Lytvynko Alla , Ryzhko Larysa
Published: October 2023

The purpose of the study is to develop a concept of a virtual space for the promotion and popularization of science and technologies for communication between scientists, society and state; promoting the inclusive development of science and technology in Ukraine; the formation of a scientific worldview and the innovative culture of society. Research methods: methods of analysis, synthesis and comparison; hermeneutic, contextual, sociological methods; systematic, transdisciplinary, prognostic-analytical, historical approaches. Results. Among benefits of the study there is the expected outcome of the research: to formulate proposals for the development of scientific communications in society, dialogue and cooperation of scientists and all age and professional strata of population; the formation of an innovative culture, critical thinking and a scientific worldview; increasing the attractiveness of the profession of a scientist, the social status of a scientist. Conclusions. The authors of the article propose the measures which should be implemented that in order to contribute to the high-quality modern training of future specialists, oriented to participate in the innovative reconstruction of Ukraine based on the latest achievements of science and high technologies, and will ensure a worthy replenishment of the personnel potential of Ukrainian science.
GENDER DIFFERENCES IN THE EFFECT OF ANTIULCER DRUGS AND PLACENTA CRYOEXTRACT ON THE INTENSITY OF LIPID PEROXIDATION AND THE ACTIVITY OF THE ANTIOXIDANT SYSTEM IN EXPERIMENTAL HEPATITIS WITH ETHANOL-INDUCED CIRRHOSIS
Authors: Koshurba Illia V. , Hladkykh Fedir V. , Chyzh Mykola O. , Marchenko Mykhailo M. , Koshurba Yurii V. , Hrishyn Volodymyr B.
Published: October 2023

Introduction. It is well recognized that drug metabolism products in the liver can induce oxidative stress and mitochondrial dysfunction, leading to the development of hepatocellular injury. As a potential agent capable of counteracting the hepatotoxic effects of drugs, we focused our attention on a domestic biotechnological preparation – cryopreserved placental extract (CPE).
The aim. To characterize gender differences in the effect of esomeprazole, clarithromycin, metronidazole (E/C/M), and CPE on the intensity of lipid peroxidation and the activity of the antioxidant system in tetrachloromethane (CCl4) hepatitis with a background of ethanol-induced cirrhosis (ETCM).
Materials and methods. The study was conducted with varying levels of sex hormones on 112 male and female rats. Chronic ETCM was induced by administering a 50.0% oil solution of CCl4 at a dose of 8 ml/kg body weight of the animals twice a week, in combination with a 5.0% ethanol solution for drinking over a period of 45 days. The content of TBA-RP in liver homogenates was determined spectrophotometrically by the method described by Asakawa T. et al. Catalase activity in liver homogenates was determined spectrophotometrically according to the method of Korolyuk M.A. and co-authors.
Results. The most pronounced increase in lipid peroxidation processes was observed in females with chronic ETCM-induced liver damage and administration of antiulcer drugs following ovariectomy, resulting in a TBA-RS content of 36.1±2.79 μmol/kg of tissue. Administration of E/C/M in animals with chronic liver damage led to a suppression of the antioxidant system, as evidenced by a decrease in catalase activity in liver tissues.
Conclusion. The combined use of anti-ulcer drugs and CPE on the background of chronic ETCM mitigated the activation of lipid peroxidation processes, which was indicated by a statistically significant (p < 0.001) 2.7-fold lower content of TBA-RP in liver homogenates. Additionally, it was established that the administration of CPE was accompanied by a statistically significant increase in catalase activity in females, more prominently than in males. In females without changes in hormonal status, the introduction of CPE resulted in a growth (p < 0.001) of catalase activity by 75.0%, with the most significant increase observed in females after ovariectomy – catalase activity statistically significantly (p < 0.001) increased by 2.6 times compared to the indicators of females not administered with CPE. The administration of CPE in female rats without altering hormonal status was accompanied by a twofold (p < 0.01) increase in the antioxidant-prooxidant index compared to male rats, indicating more pronounced antioxidant properties of CPE in female rats.
La nature juridique du nouveau régime unifié
Authors: Quinart Emilien
Published: October 2023

Le régime de responsabilité financière des gestionnaires publics est-il de nature réparatoire ou répressive ? Jusqu’en 2023, cette question peinait à trouver une réponse satisfaisante. L’ordonnance n° 2022-408 du 23 mars 2022 clarifie l’état des choses. Le nouveau régime de responsabilité des gestionnaires publics est incontestablement de nature répressive : la faute en devient le fondement assumé et la punition la finalité exclusive. Les principes généraux du droit répressif trouvent ainsi à s’appliquer devant le juge financier. Ce régime répressif de responsabilité n’est pourtant pas réductible à la responsabilité pénale ou à la responsabilité disciplinaire des agents publics. Les intérêts sociaux qu’il protège sont différents. La sélectivité des conditions de mise en cause de la responsabilité du gestionnaire public confirme aussi qu’il s’agit d’un régime administratif de responsabilité, intégrant la spécificité de l’action publique. Derrière les agents publics, c’est l’État et la collectivité tout entière qu’on protège.
L’intervention d’une chambre régionale des comptes dans le nouveau régime de responsabilité financière des gestionnaires publics
Authors: Serre Paul
Published: October 2023

Le nouveau droit de la responsabilité financière des gestionnaires publics a retiré leur fonction de jugement aux chambres régionales des comptes. Cependant l’implication de ces juridictions dans la répression des infractions financières de leur ressort reste fondée en droit, et indispensable pour l’effectivité du nouveau régime. La chambre Nouvelle-Aquitaine s’est réorganisée pour apporter tout son concours à ce changement.
Le point de vue du comptable
Authors: Barreault Samuel
Published: October 2023

La réforme de la responsabilité des gestionnaires publics apporte des évolutions positives, même si des interrogations subsistent. L’enjeu consiste à faire évoluer les pratiques en interne, à accompagner les ordonnateurs en développant la culture de la maîtrise des risques et du contrôle interne, à promouvoir des organisations plus intégrées et à mobiliser de nouveaux outils.
Le point de vue de l’ordonnateur
Authors: Privat Marine
Published: October 2023

L’un des enjeux de la réforme du régime de responsabilité des gestionnaires publics serait de recentrer les gestionnaires publics sur leur rôle et leur sens commun : faire en sorte que de manière partenariale, ils soient tous tournés vers l’efficience de l’action publique, conduisant à construire une nouvelle relation entre les acteurs.
Creation of temporary research teams to improve the quality of specialist training
Authors:   V. I. Shpilman Research and Analytical Centre for the Rational Use of the Subsoil, Kopytov Andrey G. , Levkovich Sergei V. ,   Industrial University of Tyumen, Levchenko Ivan G. ,   Tyumen Regional Duma, Pezin Dmitrii A. ,   Industrial University of Tyumen
Published: October 2023

Improving the quality of specialist training is one of the priorities of any higher education institution. According to the authors of the article, this problem can be solved by the cooperation of all parties involved in the educational process, both within the university and in cooperation with companies, which are the future employers of university graduates. The article is devoted to the study of project initiatives using the mechanism of organizing temporary research teams for the implementation of commercial contracts, with the involvement of trainees for their implementation. On the one hand, this study allowed the authors to identify the basic mechanisms of motivation of all the participants in the areas studied. On the other hand, this study allowed them to develop models for the involvement of industrial partners, their specialists, educational units, teachers and students in the implementation of commercial projects and works that improve the level of training of bachelors, masters, specialists and postgraduates.
Tactics of economic behavior of "second-tier" entrepreneurship during the sanctions period
Authors:   Industrial University of Tyumen, Simonov Sergey G. , Khamatkhanova Makka A.
Published: October 2023

The countries of the world that have accumulated experience of living under the conditions of eco-nomic sanctions of the West are marked. The main socio-economic consequences of anti-Russian Western sanctions for the "second-tier" entrepreneurship are identified. The results of surveys conducted by the Public Opinion Foundation among Russian entrepreneurs on the negative impact of Western economic sanctions on business are presented. The article examines the measures taken by small and medium-sized domestic economic entities to overcome the socio-economic consequences of sanctions pressure. The specific weights of the "second echelon" business structures that adhere to the development strategy, the survival strategy and also those who closed their business during the sanctions period are determined. The forms of organizational and legal support provid-ed by the state to domestic economic entities of small and medium-sized businesses are indicated. The role and place of tactical tools in the implementation of a self-oriented entrepreneurial strategy are substantiated. The peculiarities of the application of tactical approaches, methods and tools correcting the behavior of "second-tier" entrepreneurship during the sanctions period are revealed.
The transformation of online teaching in higher education institutions in the post-pandemic period
Authors:   Ural Institute of Management - branch of the Russian Academy of National Economy and Public Administration, Cherkasova Violetta Yu.
Published: October 2023

The relevance of this study is due to several factors. On the one hand, there is an active technical development of modern online education; on the other hand, there is a need that has developed due to the pandemic, which has forced many educational processes to go online. The year 2020 has seen a dramatic change in the work of university teachers, who have had to urgently integrate themselves into an online environment that is unfamiliar to many of them. Two years have passed, but online education is still relevant and in demand. What are the positive and negative aspects of teaching in an online environment? And how has the attitude towards online education changed over the past two years? We have tried to look at these issues from the perspective of teachers of higher educational institutions. The aim of our research is to analyze the current perception of online teaching in higher education. As a result of the sociological research conducted in 2020 and 2022 (using the online survey method), the peculiarities of the transformation of online teaching in the activities of higher education teachers were revealed. It was concluded that the attitude of teachers towards online teaching has improved. However, according to teachers, the quality of online education is still inferior to offline education and there are many problems and shortcomings. In many ways, the success of online education is due to the ability of both teachers and students to master new technical tools and to adapt to new conditions. The conclusions highlight the problems of online education and the prospects for its development. The characteristics of modern technologies are analyzed, their impact on improving the effectiveness of online education and possible options for further use are predicted.
A comparative analysis of the sociocultural origins of rock music in the USSR and the USA
Authors:   Industrial University of Tyumen, Shlyakov Alexey V. , Rebysheva Lidia V. ,   Industrial University of Tyumen
Published: October 2023

The article is devoted to a comparative analysis of the sociocultural foundations of the emergence of rock music in the USA and the USSR. The aim of the study is to identify the genesis of rock music and to analyze its characteristics in the United States and the Soviet Union. The authors have shown that a significant factor influencing the birth of rock music in the United States was the post-war socio-economic conditions: the absence of destruction in the country's infrastructure, the concentration in the United States of scientists who had fled fascism in Europe, the orientation of the country's budget towards the socio-economic sector, the demographic explosion, the emergence of leisure time. The Soviet Union, which had suffered catastrophic human losses and destruction of industry because of the war, focused the budget on raising the national economy and strengthening the military-industrial complex, so the appearance of rock music in the USSR became possible only after a full economic recovery. Despite the initial copying and imitation of American rock music by Soviet performers, the authors of the article found differences both in the musical material (form - content) and in the ideological (consumerism - sacrifice) and teleological (commodity - mission) aspects of rock music. The results of the study may be useful for philosophers, cultural scientists, as well as teachers of secondary and higher educational institutions to demonstrate the identity of the Russian cultural path using the example of rock music.
The impact of living alone on older people's attitudes to health
Authors:   Sociological Institute of the RAS — Branch of the Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences, Galkin Konstantin A.
Published: October 2023

Today there are a number of works devoted to the study of the health of older people and the particularities of their lives with various chronic diseases. In sociological research, the issue of loneliness among older people is considered separately from the issue of health. Older people's loneliness is often studied as an imposed condition rather than a conscious choice. In this study, our goal was to analyze the understanding of older people's loneliness and possible health problems of older people living alone in both urban and rural areas. The aim of this article is to consider the characteristics of everyday health care for older people in everyday life. The research method is semi-structured interviews with older people living separately in St. Petersburg and in villages of the Republic of Karelia. The method used to analyze the interviews is thematic. The main results of the work are the key issues highlighted in the study in relation to the daily life of older people and the impact of loneliness. The article shows that older people's main concern is mental health and how to maintain it, as well as the importance of communication and interaction in improving mental health. The results of the study make it im-portant to revise some ideas about the concept of active longevity, as well as the need for a special approach and planning of social policies with a focus on those older people for whom loneliness is a conscious choice. It is important to maintain mental health and support physical health for such older people.
Social controlling
Authors:   Industrial University of Tyumen, Konev Yury M. , Tretyakova Oksana V. , Baikina Yulia O. ,   Industrial University of Tyumen
Published: October 2023

The development and implementation of social controlling in management practice is linked to the increasing role of the social responsibility of companies, particularly oil and gas companies, towards society, the state, their employees and consumers. Today the main task of social controlling is to ensure continuous monitor-ing of activities, including social factors, at all levels of the management of the organization. The aim of this article is to analyze the social factors of the effectiveness of the management system in the organization. A three-year sociological study was carried out in order to determine the level of satisfaction with the management sys-tem, the organization of work and the social environment, the level of trust in the company and the relationship between these factors and the effectiveness of management in the context of social controlling. Skillful use of the data obtained will allow the heads of structural divisions to more effectively use the social factors of the working environment of the personnel to increase their return in the process of labor activity. Skilful use of the obtained data will allow managers of structural subdivisions to make more effective use of the social factors of the working environment of the personnel, to increase their efficiency in the process of work activity.
Students' opinions on the foreign policy interests of Russia and its role in the world
Authors:   Penza State University, Rozhkova Liliya V. , Dubina Albina Sh. ,   Penza State University
Published: October 2023

The study is considered in the context of existing knowledge in political sociology. Its relevance lies in the fact that our country is once again experiencing a turning point in its more than thousand-year history. Today Russia is looking for its own vector of foreign policy development, moving away from the influence of the West, but without seeking full integration with the civilizations of the East. A special military operation should be confidently seen as a catalyst for the formation of a new world order, changing the weight of countries in the international balance of power. The result will correlate with the events in the military conflict zone, changes in the structure of the world economy and measures for political resolution of the military confrontation. Our state has always remained original, but it is too early to talk about the completion of the formation of a political course. The aim of the study is to examine the issue of the political interest of modern Russian students as the most progressive and receptive part of the population and their respective sentiments on the key issues of the country's political life in relation to the state's foreign policy. As methods, the article presents: the results of a sociological survey, focus group research and in-depth interviews conducted among the student youth of the Penza region in 2023, as well as materials from other sociological studies. The article presents the results of a sociological survey, focus group research and in-depth interviews conducted among students of the Penza region in 2023, as well as materials from other sociological studies. The article reveals the preconditions, orientations and attitudes of Russian youth in the field of foreign policy, the level of trust in the authorities, the readiness of students to participate in the political life of the country, the impact of political changes on the lives of young people. Among the main results of the study, the authors pay special attention to domestic political interests and the assessment of the state's activities in the context of ongoing political events. As a conclusion, it should be noted that the materials of the presented study indicate a high level of sup-port among the young generation for the foreign policy course chosen by the country in relation to the Western coalition, a special military operation. Therefore, it is necessary to conduct a comprehensive analysis of the political orientations of modern student youth in order to identify their attitudes towards the role of Russia in the world.
A comparative analysis of satisfaction with medical services (a case study of Tyumen region)
Authors:   Industrial University of Tyumen, Belonozhko Marina L. , Barbakov Oleg M. ,   Industrial University of Tyumen, Mikhalevich Irina Ya. ,   University of Tyumen
Published: October 2023

The article presents the results of sociological research on the opinion of the population of Tyumen region on the functioning of regional health care institutions, satisfaction with the effectiveness of free state medical care, willingness to use paid medical services within the framework of the social policy of the Russian Federation. The authors found differences in the assessments of different groups of the population, differentiated by age, region of residence, level of material well-being, self-assessment of their health, although in general the vast majority of respondents assessed the quality of free medical care negatively. Discriminant analysis was used as one of the research methods, which showed a fairly clear prediction of whether residents belonged to the group of consumers of free medical care, while the accuracy of predicting the use of paid medical care turned out to be extremely low. This is explained by the fact that the use of paid medical services is currently not a naturally developing process, but simply a necessity in the presence of a rather low quality of free medical services in some cases. The article supports the thesis that the population of Tyumen region is not ready to accept serious changes in the health care system, despite the fact that the number of users of paid medical services is growing. However, there are difficulties for residents in making such a transition, as a significant number of them cannot afford to use paid services and choose, or are forced to choose, free healthcare.
Signs of stress among students: a case study of questionnaire data from the students of the Industrial University of Tyumen
Authors:   Industrial University of Tyumen, Shabatura Lyubov N. , Omelaenko Nataliya V. ,   Industrial University of Tyumen, Yatsevich Olga E. ,   Industrial University of Tyumen
Published: October 2023

The study is devoted to the analysis of the signs of stress among students of Industrial University of Tyumen. The aim of the study is to examine the signs of stress among them. The authors looked at the concept of "stress", examining physiological, emotional, intellectual and behavioural signs of stress among students. An analysis of the studied literature made it possible to identify the factors that lead young people to stress. For this purpose, a questionnaire survey was conducted in the spring of 2023 with 194 respondents between the ages of 17 and 30. The survey and data processing were conducted through the online platform Survio. The results of the study concluded that there were cognitive, behavioural, emotional and physiological signs of stress. Half of the surveyed respondents experienced stress, which could be caused not only by academic activities, but also by social, economic and political conditions, and depended on the personality, lifestyle of students and other factors. In this regard, the key focuses were proposed that help to jugulate and manage stress in the educational space.
Recurrent petit mal seizures in Erdheim-Chester disease mimicking an intra-axial brain tumor: illustrative case
Authors: Stuebe Caren M , Jenson Amanda V , Lines Tanner W , Holloman Ashley M , Cykowski Matthew D , Fung Steve H , Fisher Ronald E , McClain Kenneth L , Baskin David S
Published: October 2023

BACKGROUND

Erdheim-Chester disease (ECD) is a rare non–Langerhans cell histiocytosis characterized histologically by foamy histiocytes and Touton giant cells in a background of fibrosis. Bone pain with long bone osteosclerosis is highly specific for ECD. Central nervous system involvement is rare, although dural, hypothalamic, cerebellar, brainstem, and sellar region involvement has been described.

OBSERVATIONS

A 59-year-old man with a history of ureteral obstruction, medically managed petit mal seizures, and a left temporal lesion followed with serial magnetic resonance imaging (MRI) presented with worsening seizure control. Repeat MRI identified bilateral amygdala region lesions. Gradual growth of the left temporal lesion over 1 year with increasing seizure frequency prompted resection. A non–Langerhans cell histiocytosis with a BRAF V600E mutation was identified on pathology. Imaging findings demonstrated retroperitoneal fibrosis and long bone osteosclerosis with increased fluorodeoxyglucose uptake that, together with the neuropathologic findings, were diagnostic of ECD.

LESSONS

This case of biopsy-proven ECD is unique in that the singular symptom was seizures well controlled with medical management in the presence of similarly located bilateral anterior mesial temporal lobe lesions. Although ECD is rare intracranially, its variable imaging presentation, including the potential to mimic seizure-associated medial temporal lobe tumors, emphasizes the need for a wide differential diagnosis.
Intraoperative and postoperative complications for repeat high-grade glioma resections with concurrent chemotherapy: patient series
Authors: Ong Kenneth , Hounjet Celine , Makarenko Serge
Published: October 2023

BACKGROUND

High-grade gliomas are aggressive primary brain tumors, the most common of which is glioblastoma multiforme. Despite advances in treatment, the prognosis for these patients remains poor. The most common chemotherapeutic agents used in the treatment of this pathology include temozolomide (TMZ), procarbazine, lomustine, and vincristine. It is unclear whether chemotherapy should be held during resection for high-grade gliomas, because the perioperative risk profile is not clearly defined.

OBSERVATIONS

The authors report a case series of 18 surgeries to investigate the effects of concurrent TMZ and lomustine chemotherapy on surgical complications in patients undergoing repeat resection for recurrent high-grade gliomas. The authors found no postoperative infections, self-limiting postoperative complications, or excessive intraoperative blood loss and found one intraoperative complication.

LESSONS

There may not be a need to pause TMZ and lomustine chemotherapy during recurrent resections for high-grade gliomas, and continuing these medications throughout the perioperative period may be appropriate. This case series suggests that patients receiving TMZ and lomustine chemotherapy who need a repeat resection for recurrent high-grade gliomas should consider remaining on their chemotherapy regimen because it has been shown in the literature to improve recurrence-free survival time.
Novel combination of GammaTile cesium-131 brachytherapy with 5-aminolevulinic acid fluorescence–guided resection in the re-irradiation of pediatric recurrent high-grade glioma: illustrative case
Authors: Gordon Julian A. , Pasli Melisa , Cook Cathleen M. , Connor Rainor , Boyer Philip J. , Ju Andrew W. , Lee K. Stuart , Knudson Kathleen E. , Peach M. Sean
Published: October 2023

BACKGROUND

Herein, the authors describe the successful utilization of 5-aminolevulinic acid (5-ALA) and the first case of GammaTile cesium-131 therapy in a pediatric patient with recurrent high-grade glioma. 5-ALA was utilized to optimize gross-total resection prior to GammaTile implantation. After conversion to an equivalent dose in 2-Gy fractions (EQD2), a composite was made of the GammaTile dose with the initial external beam radiotherapy. Two hypothetical plans consisting of a standard hypofractionated strategy for glioma reirradiation and a CyberKnife plan using GammaTile’s planning target volume were developed and likewise underwent EQD2 conversion and composite plan generation with the initial radiotherapy.

OBSERVATIONS

5-ALA was useful in achieving gross-total resection with no acute toxicity from the surgery or GammaTile irradiation. When compared with the hypothetical composite doses, GammaTile’s composite, axium point dose (D0.03cc) to the brainstem was 32.9 Gy less than the hypofractionated and the CyberKnife composite plans at 38.7 Gy and 40.2 Gy, respectively. The right hippocampus demonstrated a substantially reduced composite plan dose with GammaTile with a D0.03cc of 62.4 Gy versus 71.7 and 80.7 Gy for the hypofractionated and CyberKnife composite plans, respectively.

LESSONS

Utilization of 5-ALA and GammaTile therapy yielded clinically superior tumor debulking and effective radiotherapy dose localization with sparing of organs at risk, respectively.
Clinical, imaging, and molecular features of radiation-induced glioblastomas developing more than 20 years after radiation therapy for intracranial germinomatous germ cell tumor: illustrative cases
Authors: Tsukamoto Yoshihiro , Natsumeda Manabu , Takahashi Haruhiko , Ueno Asuka , Sakai Kiichi , Shida Kazuki , Seto Hiroki , Saito Taiki , Shibuma Satoshi , Nakayama Yoko , Tanaka Yuki , Nakano Toshimichi , Ohta Atsushi , Maruyama Katsuya , Okada Masayasu , Eda Takeyoshi , Seki Yasuhiro , Yoneoka Yuichirou , Shimizu Hiroshi , Okamoto Kouichirou , Kakita Akiyoshi , Oishi Makoto
Published: October 2023

BACKGROUND

Germinomatous germ cell tumor is highly sensitive to chemoradiotherapy; patients are expected to survive for decades. Many radiation-induced malignant gliomas (RIMGs) occur >10 years after radiotherapy. Standard therapy for RIMGs has not been established because of the lesion’s rarity, the patient’s shorter survival period, and the risk of radiation necrosis by repeat radiation.

OBSERVATIONS

Two patients, a 32-year-old man and a 50-year-old man, developed glioblastomas more than 20 years after radiation monotherapy for germinoma with or without mature teratoma. The first patient showed a tumor in the left frontotemporal region with disseminated lesions and died 2 months after partial resection of the tumor without responding to the chemotherapy with temozolomide and bevacizumab. Methylation classifier analysis classified the pathology as closest to diffuse pediatric-type high-grade glioma, Rtk1 subtype. The second patient showed a tumor mass in the brainstem and left cerebellar peduncle, which worsened progressively during chemotherapy with temozolomide and bevacizumab. The tumor transiently responded to stereotactic radiotherapy with the CyberKnife. However, the patient died of RIMG recurrence-related aspiration pneumonia 11 months after the biopsy. Methylation classifier analysis classified the pathology as closest to infratentorial pilocytic astrocytoma.

LESSONS

Chemoradiotherapy may improve the survival of patients with RIMGs. Furthermore, molecular features may influence the clinical, locoregional, and pathological features of RIMG.
СТИМУЛЮВАННЯ І МОТИВАЦІЯ ПРАЦІВНИКІВ У КОТЕКСТІ ІННОВАЦІЙНОГО РОЗВИТКУ УПРАВЛІНСЬКИХ СИСТЕМ
Authors: ГАВЛОВСЬКА Наталія , РУДНІЧЕНКО Євген
Published: October 2023

У статті досліджено теоретичні основи мотивування та стимулювання. Охарактеризовано історію становлення та розвитку основних понять мотивації. Представлено еволюцію розуміння базових понять мотивування працівників та визначення особливостей мотиваційного процесу різних сфер інноваційної діяльності на підприємствах. Досліджено підходи вітчизняних та іноземних науковців до бачення мотиваційних процесів, процесів стимулювання персоналу та визначення потреб. Наведено науково-методичні підходи до розуміння теорій «Х», «Y», «Z» та характеристику змістовних теорій мотивації. Доведено, що мотивація інноваційного розвитку – це стимулювання управлінської діяльності, яка ґрунтується на прийнятті та реалізації прогресивних рішень з метою впровадження нововведень, і спрямована на досягнення особистих та інноваційних цілей розвитку організації. Розроблено схему мотиваційного процесу інноваційної діяльності.
Higher order evolution inequalities involving Leray–Hardy potential singular on the boundary
Authors: Jleli Mohamed , Samet Bessem , Vetro Calogero
Published: October 2023

We consider a higher order (in time) evolution inequality posed in the half ball, under Dirichlet type boundary conditions. The involved elliptic operator is the sum of a Laplace differential operator and a Leray–Hardy potential with a singularity located at the boundary. Using a unified approach, we establish a sharp nonexistence result for the evolution inequalities and hence for the corresponding elliptic inequalities. We also investigate the influence of a nonlinear memory term on the existence of solutions to the Dirichlet problem, without imposing any restrictions on the sign of solutions.
Investigation of Microstructure and Residual Stress of Ti-6Al-4V Ultrasonic Assisted Welding Joint
Authors: Wang Jianxin , Guo Yupeng , Yu Huan , Deng Hailong , Liu Xukai , Wang Weidong
Published: October 2023

The welded joint of TC4 titanium alloy is easy to form coarse grain, and there is a large residual stress and residual deformation after welding. By applying ultrasonic aid in the conventional TIG welding process, the ultrasonic amplitude converter is directly contacted with the TC4 titanium alloy plate, and the ultrasonic cavitation effect generated by ultrasonic vibration and the mechanical vibration stirring effect are used to influence the flow and solidification process of liquid metal in the weld pool, so as to refine the microstructure and grain of the weld and reduce the residual stress of the weld. The grain size and residual tensile stress of welded TC4 titanium alloy joints under different ultrasonic power were measured. Compared with conventional TIG welding, the average grain size of the weld is reduced by 22.70 % and the average residual stress release rate is 82 % when 2000 W ultrasonic power is applied. Grain refinement can increase grain boundary number and improve material strength. Reducing the residual stress of weld can further reduce the fatigue crack propagation rate of weld. Therefore, it is of practical significance to improve the weld microstructure and reduce the residual stress of welded joints by ultrasonic assisted welding technology to improve the strength and reliability of welded structures.
Influence of Rotating Speed on Pressure Distribution in the Working Process of Milk Separator
Authors: Wang Lulu , He Jianhua , Tang Lianyao , Wang Yage , Chen Weidong
Published: October 2023

The milk separator belongs to the disc separator, which is the key core equipment for dairy products processing. Its core functional component, the separation bowl, works at a rotating speed ranging from 7500 r/min to 12000 r/min, and structurally belongs to a vertical high-speed rotor with external suspension and external center of gravity. The thin-layer separation centrifugal flow field inside the separation bowl and the structural stress of the rotor are the key application basic theories in the design of the milk separator. The influence of rotating speed on the pressure distribution during the working process of milk separator is that the dynamic pressure simulation results of the flow field are distributed near the theoretical curve at all rotating speeds, and the simulation results are reasonable, especially the difference between the dynamic pressure distribution of the fluid in the disc channel and the theoretical value is very small. The research on the influence of rotating speed on pressure distribution in the working process of milk separator has very important theoretical value and application value for revealing the separation mechanism of milk fat, optimizing the structure design of separation bowl and developing new products.
NISO's Content Profile/Linked Document standard: A research communication format for today’s scholarly ecosystem
Authors: Kasdorf Bill
Published: October 2023

This paper is based upon the author’s presentation at the 2023 NISO Plus Conference in which he discussed the purpose and importance of the NISO Content Profile/Linked Document standard. The need for the standard is obvious: users demand the delivery of contextualized, targeted content delivered as a natural part of their workflow and publishers aspire to produce machine-actionable FAIR (Findable, Accessible, Interoperable, Reusable) materials, but many publishing workflows are focused on articles, often published after research is concluded. This standard is an application of HTML5 and JSON-LD to create semantic relationships between data elements in scholarly publishing workflows and express machine actionable content, to ease reuse and interchange of scholarly research information. The format description defines a set of rules that outline the minimal characteristics of documents (Linked Documents) that conform to the standard and a mechanism to define more detailed Content Profiles that extend and refine the rules for specific use cases.
Saddle-point solution to zero-sum games subject to noncausal systems
Authors: Chen Xin , Wang Yan , Li Fuzhen
Published: October 2023

A singular system, assumed to possess both regularity and freedom from impulses, is categorized as a causal system. Noncausal systems (NSs) are a class of singular systems anticipated to exhibit regularity. This study focuses on investigating zero-sum games (ZSGs) in the context of NSs. We introduce recurrence equations grounded in Bellman’s optimality principle. The saddle-point solution for multistage two-player ZSGs can be obtained by solving these recurrence equations. This methodology has demonstrated its effectiveness in addressing two-player ZSGs involving NSs. Analytical expressions that characterize saddle-point solutions for two types of two-player ZSGs featuring NSs, encompassing both linear and quadratic control scenarios, are derived in this paper. To enhance clarity, we provide an illustrative example that effectively highlights the utility of our results. Finally, we apply our methodology to analyze a ZSG in the realm of environmental management, showcasing the versatility of our findings.
Modeling The Term Structure of Commodity Futures Curve and Empirical Study
Authors: Lee David
Published: October 2023

Commodity derivatives trading typically depends on futures/forwards. As such, there is a need to model the dynamics of futures curves. This article presents a model for valuing commodity derivatives by decomposing the futures term structure into its principal components and studying their economic divers. We also propose generic online and offline approaches for model calibration. Empirical study shows that the model can better capture the commodity seasonality, price dynamics, and volatility skew/smile.