bluuebunny/crossref_metadata_2025 huggingface dataset:
Cyclic di-AMP Rescues Porphyromonas gingivalis–Aggravated Atherosclerosis
Authors: Wu Q. , Li Z. , Zhang Y. , Luo K. , Xu X. , Li J. , Peng X. , Zhou X.
Published: April 2023

Growing evidence demonstrates the relationship between periodontitis and atherosclerotic cardiovascular diseases. The periodontal pathogen Porphyromonas gingivalis (Pg) has been shown to contribute to the progression of atherosclerosis. Cyclic diadenylate monophosphate (c-di-AMP) has been widely studied as an immune adjuvant for tumor immunotherapy, given its ability to activate the stimulator of interferon genes (STING) and regulate trained immunity. This study sought to elucidate the role of c-di-AMP in Pg-associated atherosclerosis. Periodontitis and atherosclerosis mouse models were established by ligature application around maxillary second molars and feeding ApoE knockout mice with a high-fat diet. We found that periodontitis and atherosclerosis were more severe in mice exposed to Pg than mice that underwent ligature placement only, while prophylactic treatment with c-di-AMP activated trained immunity and elicited significant alleviation of alveolar bone resorption, as well as reduced blood lipid levels and atherosclerotic plaque accumulation. After 3 mo of intervention, c-di-AMP limited the elevation of cytokines interleukin (IL)–6, IL-1β, tumor necrosis factor α, and interferon β; extracellular matrix remodeling enzymes MMP-2 and MMP-9; and adhesion molecules ICAM-1 and VCAM-1 gene expression. The mechanism underlying Pg-aggravated atherosclerosis may be attributed to changes in microbiota composition in oral and aortic plaques and excess inflammatory response, whereas c-di-AMP could prevent the effects of Pg infection due to its potential ability to activate trained immunity and regulate microecological balance. Our findings suggest a positive role of c-di-AMP in alleviating Pg-aggravated atherosclerosis by regulating the immune response and influencing the local microenvironment.
Assessment of Health-Related Quality of Life Among Male Patients With Controlled and Uncontrolled Hypertension in Semi Urban India
Authors: Patil Mansi , Hedaoo Radhika Prashant , Shah Rohan Pravinbhai , Tauseef Syed Mohammad , Marzo Roy Rillera , Ching Siew Mooi , Lambert Gavin
Published: April 2023

The burden of hypertension has been growing over recent decades. In addition to risk of stroke and cardiovascular disease development, data indicates that hypertension may also pose a hazard to the quality of life (QoL) of individuals. Patient reported outcomes such as QoL are often overlooked, with physicians and healthcare professionals not routinely evaluating or customizing treatments according to QoL. In this study we aimed to assess the QoL of hypertensive men (n = 500) undergoing treatment who visited a charitable hospital in Pune, India. Clinic blood pressure was determined and the Mini Cuestionario de Calidad de Vida en Hipertensión Arterial (MINICHAL) scale was used to assess the health-related (HR)-QoL of patients. More than half of the participants (62%) had uncontrolled hypertension, with a mean systolic blood pressure (BP) of 151 ± 12 mmHg and diastolic blood pressure of 87 ± 6 mmHg as compared to those with controlled blood pressure (mean systolic blood pressure 123 ± 6 mmHg and diastolic blood pressure 84 ± 5 mmHg; P < .01 for both). Predominantly the participants were overweight with body mass index (BMI) of those with uncontrolled hypertension being greater than those with controlled blood pressure (28.4 ± 3.3 kg/m2 vs 23.3 ± 2 kg/m2, P < .01). A reduced QoL was observed for participants with uncontrolled hypertension (overall score 41 ± 5) as compared to those with controlled blood pressure (35 ± 4, P < .001). This was evident on both the mental plane [2.8 ± 2.5 (95% CI = 2.3-3.1) vs 4.1 ± 3.2 (95% CI = 2.5-3.3)] and somatic domain [3.4 ± 3.2 (95% CI = 3.0-4.0) vs 4.7.4 ± 3.5 (95% CI = 3.1-4.5)] where the QoL was poorer ( P < .001) for the uncontrolled hypertensive group. Poorer QoL was observed for people with uncontrolled hypertension. This study indicates that the QoL in patients with uncontrolled hypertension attending an outpatient clinic in India is worse than those with controlled blood pressure. Future studies need to be undertaken to ascertain whether an impaired QoL impacts the outcomes associated with high blood pressure.
An actor-partner model of partner phubbing, mobile phone conflict, and relationship satisfaction between romantic partners in Liberia
Authors: Togar Euriahs M. , Vanden Abeele M. M. P. , van Wijk Carel H. , Yasin Raja Mehtab , Antheunis Marjolijn L.
Published: April 2023

Using the Actor-Partner Interdependence Model, this study investigates among Liberian couples whether partner phubbing predicts relationship satisfaction, both directly and indirectly via mobile phone conflict. Moreover, this study examines whether phubbing by men is less likely to lead to conflict than that by women given the differential power relations and income distributions in Liberian romantic couples. Using data from married, cohabiting, and couples living apart ( N = 128) in Liberia, a direct link was found between the phubbing behavior of women and partner’s (men) relationship satisfaction. Moreover, men and women’s phubbing behavior predicted their own and their partner’s experience of mobile phone conflict, which in turn predicted a decrease in relationship satisfaction. Power imbalance between men and women, as well as income disparity, were found to influence some of the relationships between partner phubbing, phone conflict, and relationship satisfaction, but did not give substantial support to the hypotheses that women would elicit more conflict than men in couples characterized by high power imbalance and income inequality. Overall, the study shows the importance of examining interdependence effects in phubbing research and supports that there is meaningful cross-cultural variation that warrants further scrutinizing.
Exercise interventions for advanced cancer palliative care patients: A systematic literature review and descriptive evidence synthesis of randomized controlled trials
Authors: Rogers-Shepp India , Bhattacharya Souradeep , Mennillo Haran A , Kumar Ritika , Hsieh Ben , Anandarajah Gowri
Published: April 2023

Background:

Exercise is often recommended for cancer patients. However, for advanced cancer palliative care patients, it is unclear whether exercise, as a lifestyle intervention, is beneficial for palliative outcomes.

Aim:

To examine randomized controlled trials assessing the effectiveness of lifestyle exercise interventions on palliative outcomes in patients with advanced stage cancer.

Design:

Systematic review and descriptive evidence synthesis.

Data sources:

Pubmed/Medline, Embase, CINAHL, PsychInfo, and Web of Science were systematically searched from inception to 2022. Two reviewers identified articles and removed duplicates. Next two reviewers independently screened titles and abstracts and then assessed full-texts articles for eligibility. Finally, all six reviewers examined full-text articles for eligibility and conducted the evidence synthesis.

Results:

Eight randomized controlled trials were included. Studies were heterogeneous making direct comparisons challenging, but were grouped along three categories: aerobic, resistance, or resistance-aerobic exercises. One of three aerobic studies had positive quality-of-life outcomes. Fatigue improved in one aerobic and one combination resistance-aerobic study. Most resistance-aerobic studies and one aerobic study showed improved physical function. All resistance studies showed improvement in at least one outcome. Across all studies, ill health was the most common reason for participant dropout. The most commonly used assessment tools were: Functional Assessment of Cancer Therapy: Fatigue, European Organization for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30, and accelerometer.

Conclusion:

Current randomized controlled trials regarding effects of exercise interventions on palliative outcomes for advanced cancer patients show great variability. While studies show promise, no generalizable conclusions can be made. Further research is needed.
Acts of contrition: Forgiveness and effective intergroup apologies for historical institutional abuse
Authors: McAlinden Anne-Marie
Published: April 2023

This article examines some of the complexities of the apology–forgiveness nexus within the context of intergroup apologies by church and state for historical institutional abuse (HIA). Drawing on primary research conducted in Ireland, North and South, including the voices of a sample of victims/survivors, it argues that effective intergroup apologies for HIA and the extent to which they might elicit forgiveness among victimized communities are impacted by a range of factors including (1) leader apologies and the ‘normative dilution effect’; (2) the lack of emotion and remorse; and (3) in the case of church apologies in particular, the use of religious rhetoric and ritual. The analysis ultimately suggests that while ‘pure’ forgiveness may not be possible in this specific context, effective intergroup apologies for HIA, delivered in a collective, public context, which have the potential to promote forgiveness among victims/survivors, are those which closely approximate the relational dimensions of private, interpersonal apologies. This entails demonstrating emotion; humility; proximity to historical wrongdoing; connectivity with victims/survivors; and the commitment to non-recurrence.
Strengthening Early Intervention Home Visitation Quality: A Focus on Partnerships and Interactions
Authors: Kuhn Miriam , Higgins Johanna
Published: April 2023

Early intervention (EI) home visitation programs are central to delivering services that support infants and toddlers displaying developmental delays or disabilities and their families. Entities that oversee such programs continually seek to strengthen the quality of program practices. The Getting Ready approach is a professional development (PD) framework for partnering with families and delivering high quality routines-based home visits. Interviews were conducted with family members ( n = 22), EI service providers ( n = 12), and independent, dedicated EI service coordinators ( n = 7) in a midwestern U.S. state, and written home visit action plans from professionals’ home visits ( n = 11) were reviewed. Findings from qualitative analyses of these two data sources deepen understanding of effective family-professional partnerships, data-driven decision-making processes, and collaborative development of routines-based interventions focused on family-child interactions and the achievement of child/family IFSP outcomes.
Observational studies - The Cinderella of the Italian research system
Authors: Cagnazzo Celeste , Basiricò Marco , Palermo Federica , Fagioli Franca
Published: April 2023

Observational trials are crucial to assess the generalizability in the real world of evidence deriving from registration studies. Despite the unquestionable importance of this type of studies, Italian researchers have had to face many obstacles over the years, mainly due to ambiguous definitions and to a complex but at the same time incomplete legislation. The regulatory adjustments to the European Regulation 536/2014 have further complicated the operating and operational framework, making observational research a real "Cinderella" of the Italian system.
Machine-Learning-Based Framework for Prediction of the Long-Term Field Performance of Asphalt Concrete Overlays in a Hot and Humid Climate
Authors: Mansour Elise , Mousa Momen R. , Dhasmana Heena , Hassan Marwa
Published: April 2023

Pavement performance prediction models are used by state agencies to determine pavement maintenance and rehabilitation strategies. However, most performance prediction models are based on a limited number of parameters and a maximum prediction period of five years. With the ever-increasing amount of available pavement performance data, machine-learning techniques have become a promising alternative to traditional performance prediction models. The objective of this study was to develop a machine-learning-based framework for states with a hot and humid climate that can predict the long-term field performance (up to 11 years) of asphalt concrete (AC) overlays on asphalt pavements based on key project conditions. The pavement condition index (PCI) was used as the pavement performance indicator. Two machine-learning algorithms, namely, random forest (RF) and CatBoost, were examined. A total of 892 log-miles of AC overlay data were obtained from the Louisiana Department of Transportation and Development Pavement Management System database. Based on the collected data, six models were trained (for each algorithm) and validated to predict the PCI of AC overlays for up to 11 years. The results indicated that the RF algorithm yielded higher accuracy than the CatBoost algorithm. Therefore, the RF-based models were considered in the proposed decision-making framework.
Black Communities’ Perspectives on High-Risk Domestic Violence
Authors: Bent-Goodley Tricia , Romero-Chandler Sakima , Zonicle Aaliah
Published: April 2023

Domestic violence homicide is a serious issue that is receiving increased attention in communities across the country. The Black community has been disproportionately impacted by domestic violence fatality. However, little information has been obtained as to how these communities understand and perceive high-risk domestic violence. This article provides information from 128 focus group participants from diverse Black communities on their perceptions of what constitutes high-risk domestic violence. The findings affirm some current high-risk indicators, such as stalking, strangulation, use of threats, access to a weapon, and isolation, and provide nuanced perspectives of each indicator. In addition, the findings provide new thoughts on what these communities identified as high-risk domestic violence, including public violence, repeated violence with no consequences, escalation of arguments, disconnection from the community, and being a member of a marginalized group. Implications for practice, policy, education, and protocol development are provided.
Study on flow separation and suction control of a compressor tandem cascade
Authors: Zhang Botao , Mao Xiaochen , Liu Bo , Wang Hejian , Yang Zonghao , Zhang Ran
Published: April 2023

To control the boundary layer separation on the front blade suction surface in a compressor tandem cascade at a high incidence angle, three suction schemes at different axial positions were introduced and the cascade performance improvement and separation flow control effects were investigated. Based on the experimental and numerical simulations, the aerodynamic performance of the prototype tandem cascade reaches the peak at the incidence angle of 5°. Continue to increase the incidence angle, the loss increases sharply, and the static pressure rise coefficient and diffusion factor begin to decrease. With the boundary layer suction on the suction surface of the front blade, fluid energy in the upstream boundary layer of the suction slot is increased, and the adverse pressure gradient downstream is decreased. By suction, the development and separation of the boundary layer are inhibited, and the loss in the tandem cascade is significantly reduced. The flow control effect of the suction scheme at the onset location of boundary layer separation is the best, and the flow loss can be reduced by about 34.9% with a suction flow rate of 1% at the incidence angle of 5°. The suction schemes have good flow control effects in a wide working range and broaden the available range of incidence angles of the tandem cascade. This study provides a reference for the design of tandem blades considering flow control and has a positive significance for improving compressor efficiency and pressure ratio.
Europe’s semiconductor industry at a crossroads: Industrial policy and regional clusters
Authors: Johnston Andrew , Huggins Robert
Published: April 2023

The European Union has agreed to provide significant investment to the semiconductor industry in order to address issues of self-sufficiency and digital sovereignty. This comes on the back of the long-term decline in the competitiveness and size of the industry in Europe. These issues are of considerable significance to urban and regional economic development agendas as the industry is clustered around several European regions. This commentary seeks to examine the extent to which European policy intervention is likely to positively influence Europe’s semiconductor industry. It is argued that the European semiconductor industry is at a crossroads. While it has some competitive advantages and is home to several significant clusters, it faces incessant competition from producers in Asia and the United States. It is argued that European policy should not be space neutral and aim to encourage innovation and enterprise within the sector in conjunction with existing European regional economic development policy measures. Within this approach, supporting key existing clusters through triple helix models of development are likely to be the most effective modes of intervention.
Preliminary investigation of hepatitis E virus detection by a recombinase polymerase amplification assay combined with a lateral flow strip
Authors: Li Manyu , Li Tingting , Hao Xiaotian , Liu Yan , Lan Haiyun , Zhou Cheng
Published: April 2023

Hepatitis E virus (HEV) is a zoonotic pathogen that is a significant public health problem. Detecting HEV relies mainly on conventional PCR, which is time-consuming and requires sophisticated instruments and trained staff. We aimed to establish a reverse-transcription (RT)-recombinase polymerase amplification (RPA) assay (RT-RPA) combined with a lateral flow strip (LFS; RT-RPA-LFS) to rapidly detect HEV RNA in human and rabbit samples. With the optimal reaction conditions (37°C for 30 min), our assay detected as few as 1.0 × 102 copies/mL of HEV and showed no cross-reactivity with other hepatitis viruses. We tested 28 human samples (4 fecal and 24 serum samples) and 360 rabbit samples (180 fecal and 180 serum samples) with our RT-RPA-LFS assay and compared our assay to an RT-qPCR method. There was no significant difference ( p > 0.05) in the test results between the 2 assays. Our RT-RPA-LFS assay detected both HEV3 and HEV4 genotypes. Our rapid, sensitive, and specific RT-RPA-LFS assay for the detection of HEV may provide a useful detection tool for limited-resource areas.
Intractable Feeding Intolerance in Children With Severe Neurological Impairment: A Retrospective Case Review of Nine Children Known to a Pediatric Palliative Care Service
Authors: Katz Naomi T , Cooper Monica S , Kularatne Aeshan , Prebble Anna , McGrath Kathleen H , McCallum Zoe , Antolovich Giuliana , Sutherland Ingrid , Sacks Bronwyn H
Published: April 2023

Background: Intractable feeding intolerance in children with severe neurological impairment (SNI) is poorly defined and understood. Objectives: (1) To describe 9 children with SNI, where intractable feeding intolerance was thought to be a contributor to their deterioration or death. (2) To consider terminology to describe the severe end of the spectrum of feeding difficulties in children with SNI. Results: Mean age at death was 10.3 years (range: 5 – 15.6), and median time from palliative care referral to death was 3.1 months. Location of death was home (n = 3), hospice (n = 1), and hospital (n = 5) with 1 death in intensive care. Gastrointestinal “failure” or “dysfunction” were documented for 7 children, (median time between documentation and death was 3.9 months (range: .1 to 13.1)). All children were fed via a gastrostomy tube during their life (median age of insertion 2.5 years (range: 1.2 to 6.8 years)), and 7 via the jejunal route (median age of insertion 9.2 years (range 2.4 to 14.7 years)). Children lived a median of 9 percent of their lives after jejunal tube feeding was commenced. No child had home-based parenteral nutrition. Multiple symptom management medications were required. Conclusion: ‘Intractable feeding intolerance’ describes a clinical crossroads in a child’s life where there is an opportunity to consider the appropriateness of further interventions. Further work should explore predictors of intractable feeding intolerance and the delicate balance between cause or contributor to death. The importance of clinician-family prognostic conversations and goal-concordant care both during life and in the terminal phase is highlighted.
The RANA Model Revisited: How a Primary Nursing Model for Professional Psychiatric Nursing Practice Has Withstood the Test of Time
Authors: Meyers Stacey M. , Roberts Patricia , Slade Maureen
Published: April 2023

Objective:

This article revisits the responsible, accountable nurse with authority (RANA) model and its continued application to psychiatric-mental health nursing care nearly 30 years after its development. It will ascertain key elements of the model that remain in use today, while identifying parts of the model that have transformed over the years.

Methods:

This article will also explore the theoretical underpinnings of the model, including Peplau’s interpersonal relations theory. The impact of the primary nursing and relationship-based care models that influenced the RANA role will also be explored.

Results:

Specific examples of how the RANA model has affected unit outcomes will be identified, such as improved patient safety measures and satisfaction with care.

Conclusions:

The nurse–patient relationship and therapeutic alliance is fundamental to the RANA model and directly affects patient outcomes.
Aggression Is Associated With Social Adaptive Functioning in Children With ASD and Anxiety
Authors: Kalvin Carla B. , Jordan Rebecca , Rowley Sonia , Weis Anna L. , Ibrahim Karim , Sukhodolsky Denis G.
Published: April 2023

Social adaptive functioning is notably compromised and may be further impaired by aggressive behavior in children with autism spectrum disorder (ASD). This study examined the association between aggressive behavior and social adaptive skills in children with ASD and the contribution of aggressive behavior to social adaptive skills in a combined sample of children with and without ASD. Participants consisted of children, ages 8 to 15 years, with ASD ( n = 52) and who were typically developing ( n = 29). Results indicate that aggressive behavior is negatively associated with social adaptive skills in children with ASD and that it contributes to reduced social adaptive functioning above and beyond ASD diagnosis. Findings underscore the importance of considering the role of aggressive behavior when evaluating and promoting social functioning in children with ASD.
Advanced model-based closed-loop combustion control strategies with combustion rate shaping
Authors: Srivastava Vivek , Schaub Joschka , Pischinger Stefan
Published: April 2023

Combustion rate shaping (CRS) is an advanced closed-loop concept which controls the crank-angle resolved combustion trace by adapting the fuel injection profile. The thermodynamic potential of this concept to enable real-time combustion control independent of fuel property variations, injector drift, cylinder tolerances, or changing air-path boundary conditions has already been demonstrated. The highest benefit of this control concept is achieved when it is directly applied on the engine control unit (ECU) in combination with an in-cylinder pressure measurement. This enables online optimization and adaption of the fuel- and air-path settings to the fuel used during vehicle operation. Therefore, the development of a CRS concept with real-time capability has been the main focus so far. To ensure a robust online real-time combustion control, a key development step was the identification of control variables that describe the entire combustion process and only minimally influence each other. For this purpose, the combustion phasing, the combustion gradient and the indicated mean effective pressure have been determined as parameters for the feedback control. However, the stringent requirements for higher efficiencies, emission robustness and combustion noise necessitate the extension of the CRS control concept. Therefore, in this work, the CRS control concept is extended with the aim of realizing a combustion with constant volume pressure increase to the peak firing pressure limit to achieve highest efficiency. In addition, intelligent control of the fuel injection profile is to be used to achieve a combustion temperature for lowest possible NOx raw emissions and a robust combustion noise excitation limitation. The optimized control strategy is implemented on a heavy-duty single cylinder engine test bench using a Rapid Control Prototyping (RCP) system, and the control performance is demonstrated.
A scoping review of psychosocial interventions to enhance the relationship of couples living with dementia
Authors: Gilbert Emma , Villa Darrelle , Riley Gerard A
Published: April 2023

When dealing with the challenges of dementia, spousal relationships have a central role to play in outcomes such as quality of care and emotional wellbeing. Dementia places strain on these relationships and so it is important to develop interventions to support them. This review maps out what interventions have been employed in this context. Searches of PsycInfo, PsycArticles, CINAHL, Embase, MEDLINE, and Web of Science were conducted to find studies describing interventions that aimed to improve some aspect of the relationship. Thirty-four studies were identified. A wide range and diversity of interventions were described, including life review, psychotherapy and ones focused on communication or creative activity. Reported benefits included meaningful interaction, emotional connection, reduced conflict and negativity, an increase in mutual support, and greater equality in the relationship. However, these can only be considered as potential rather than proven benefits because of the lack of methodological rigour of most of the studies. Future research on this topic would benefit from a closer links with research on the impact that dementia can have on spousal relationships, and from the use of stronger methodology.
Impact of cognitive capacity on physical performance in chronic obstructive pulmonary disease patients: A scoping review
Authors: Rassam Peter , Pazzianotto-Forti Eli M. , Matsumura Umi , Orchanian-Cheff Ani , Aliabadi Saina , Kulkarni Manjiri , Fat Fur Rachel L. , Rodrigues Antenor , Langer Daniel , Rozenberg Dmitry , Reid W Darlene
Published: April 2023

Background: Chronic obstructive pulmonary disease (COPD) is often accompanied by impaired cognitive and physical function. However, the role of cognitive function on motor control and purposeful movement is not well studied. The aim of the review was to determine the impact of cognition on physical performance in COPD. Methods: Scoping review methods were performed including searches of the databases: MEDLINE, EMBASE, Cochrane Systematic Reviews, Cochrane (CENTRAL), APA PsycINFO, and CINAHL. Two reviewers independently assessed articles for inclusion, data abstraction, and quality assessment. Results: Of 11,252 identified articles, 44 met the inclusion criteria. The review included 5743 individuals with COPD (68% male) with the forced expiratory volume in one second range of 24–69% predicted. Cognitive scores correlated with strength, balance, and hand dexterity, while 6-min walk distance ( n = 9) was usually similar among COPD patients with and without cognitive impairment. In 2 reports, regression analyses showed that delayed recall and the trail making test were associated with balance and handgrip strength, respectively. Dual task studies ( n = 5) reported impaired balance or gait in COPD patients compared to healthy adults. Cognitive or physical Interventions ( n = 20) showed variable improvements in cognition and exercise capacity. Conclusions: Cognition in COPD appears to be more related to balance, hand, and dual task function, than exercise capacity.
First-in-Human µCAB™ Coronary Revascularization Surgery
Authors: Živković Igor , Mićović Slobodan , Milačić Petar
Published: April 2023

Less invasive coronary artery bypass grafting surgery is underused despite more than 25 years of interest from surgeons and growing patient demands for less pain and rapid full recovery. New approaches may offer surgeons additional options to provide enhanced clinical results through reliable subxiphoid bilateral internal thoracic artery harvesting and the creation of durable anastomoses through very small thoracotomy incisions. This first-in-human case report describes 2 patients who received surgical coronary revascularization using the µCAB™ technology and techniques. The encouraging early results indicate that the µCAB™ approach may offer a new ergonomic, affordable method for coronary revascularization with less surgical trauma.
Prognostic value of bone resorption pattern in the anterior portion of the femoral head in Legg–Calvé–Perthes disease
Authors: Mishima Kenichi , Kamiya Yasunari , Matsushita Masaki , Imagama Shiro
Published: April 2023

Purpose:

To examine whether differences in bone resorption patterns in the anterior portion of the femoral head correlate with the prognosis of Legg–Calvé–Perthes disease.

Methods:

Seventy-eight patients with unilateral Legg–Calvé–Perthes disease, who were diagnosed after 6.0 years of age, underwent the Salter innominate osteotomy from 1987 to 2013, and were followed up to skeletal maturity. The anterior bone resorption pattern of the femoral head was evaluated from a frog-leg lateral hip radiograph made in the middle of the fragmentation period, and classified into two types, an epiphysis-preserved type (P) and a physis-disrupted type (D). The correlation between the type of bone resorption and the Stulberg outcome was analyzed.

Results:

The Stulberg outcomes were grade I for 9 patients, grade II for 31, grade III for 35, and grade IV for 3, with a mean follow-up period of 8.3 ± 2.7 years. Fifty-one patients demonstrated the type P hips and 27 did the type D hip. In a subset analysis of patients with the modified lateral pillar group-B hips in the younger group (6.0–8.9 years of age at diagnosis), the percentages of the favorable and unfavorable outcomes significantly differed between the two types ( p = 0.013). Anteroposterior enlargement of the affected femoral head was significantly greater in the type D hips than the type P hips ( p = 0.014).

Conclusion:

Unfavorable hip morphology at skeletal maturity can be predicted in patients with the lateral pillar group-B hips by focusing on bone resorption patterns of the anterior portion of the femoral head.

Level of evidence:

Level III, prognostic study.
Validity of Research Based on Publicly Obtained Data in Sports Medicine: A Quantitative Assessment of Concussions in the National Football League
Authors: Inclan Paul M. , Kuhn Andrew W. , Chang Peter S. , Mack Christina , Solomon Gary S. , Sills Allen K. , Matava Matthew J.
Published: April 2023

Context:

Numerous researchers have leveraged publicly available internet sources to publish clinical research concerning incidence and recovery from injuries in National Football League (NFL) players.

Objective:

This study aims to (1) provide a comprehensive systematic review of all publicly obtained data studies (PODS) regarding concussions in NFL athletes and (2) quantify the percentage of injuries identified by these studies in comparison with published concussion data from the NFL injury database.

Study Selection:

A systematic review was conducted in accordance with PRISMA guidelines to identify all published studies utilizing publicly obtained data regarding concussions in NFL athletes.

Study Design:

Systematic review.

Level of Evidence:

Level 4.

Data Extraction:

Manuscript details, factors related to the athletes of interest (eg, study period, positions included), and results (eg, concussion rate, number of total concussions, return-to-play data) were extracted independently by 2 authors. Results were compared with incident concussions reported from 2015 to 2019 by each medical staff member to the NFL database linked to the League’s electronic health record (EHR).

Results:

A total of 20 concussion-focused manuscripts based on PODS were identified from 2014 to 2020. PODS captured between 20% and 90% of concussions (mean, 70%) reported by medical staff to the injury database. PODS reported that 55% of concussions occurred on offensive plays, 45% on defensive plays and <1% occurred during special teams plays, compared with 44%, 37%, and 18%, respectively, as indicated by published data from the NFL injury database. When analyzed by position groups, running backs and quarterbacks comprised the most over-represented positions concussed in PODS, while offensive linemen, defensive backs, and linebackers comprised the most under-represented positions.

Conclusion:

PODS captured approximately 70% of concussions reported by NFL medical staff to the NFL injury database. There is heterogeneity in the degree to which PODS were able to identify concussions, with a bias toward concussions among players at higher profile positions.
Love in the Time of COVID-19: The Social Dimensions of Intimate Life under Lockdown
Authors: Borsa Alexander , Calleo Maximillian , Faires Joshua , Kaplan Golda , Sharif Shadiya , Zhang Dingyu , Meadow Tey
Published: April 2023

Although popular media across the United States reported that the coronavirus disease 2019 COVID pandemic incited dramatic transformations in personal relationships, identities, and practices, little sociological research examines these developments. What exists elaborates the “how” and “how much” of sex, the frequency of sexual conduct, and changes in the patterning of sexual behavior. In this study of the intimate trajectories of 46 young adults, conducted during the height of U.S. quarantine restrictions in 2020 and early 2021, the authors explore the “whys” of sex. They find that the exogenous force of the pandemic profoundly altered individual relationship trajectories, prompted sexual introspection projects, shifted understandings of sexual risk, and promoted new modes of intimacy. These findings suggest that pandemic life reached deep into subjective self-understandings and ways of relating to others. They also reveal the benefits of foregrounding cultural meanings over behaviors, changes in thoughts over actions, and social processes over individual outcomes.
Effect of Lens Status on Diabetic Vitreous Hemorrhage Resolution
Authors: Zeng Ke , Cabral Howard , Ness Steven , Subramanian Manju , Siegel Nicole , Chen Xuejing
Published: April 2023

Purpose: To determine the effect of lens status (pseudophakic vs phakic) on diabetic vitreous hemorrhage (VH) resolution time. Methods: Medical records were reviewed retrospectively for each case of diabetic VH until resolution, pars plana vitrectomy (PPV), or loss to follow-up. Univariate and multivariate Cox regression models were used to determine predictors of diabetic VH resolution time through estimated hazard ratios (HRs). Kaplan-Meier survival analysis compared differences in the resolution rate by lens status and other significant factors. Results: Overall, 243 eyes were included. Pseudophakia (HR, 1.76; 95% CI, 1.07-2.90; P = .03) and prior PPV (HR, 3.28; 95% CI, 1.77-6.07; P < .001) were significant factors for faster resolution. Pseudophakic eyes resolved in 5.5 months (median, 25.1 weeks; 95% CI, 19.3-31.0) and phakic eyes in 10 months (median, 43.0 weeks; 95% CI, 36.0-50.0) ( P = .001). More pseudophakic eyes than phakic eyes resolved without PPV (44.2% vs 24.8%) ( P = .001). Eyes without prior PPV resolved in 9.5 months (median, 41.0 weeks; 95% CI, 35.7-46.3) compared with 5 months (median, 22.3 weeks; 95% CI, 9.8-34.8) in vitrectomized eyes ( P < .001). Age, treatment with antivascular endothelial growth factor injections or panretinal photocoagulation, intraocular pressure medications, and glaucoma history were not significant predictors. Conclusions: Diabetic VH resolved almost twice as fast in pseudophakic eyes than in phakic eyes. Eyes with a history of PPV resolved 3 times quicker than those without PPV. A better understanding of VH resolution can help personalize the decision on when to proceed with PPV.
Modeling future economic costs and interdependent industry recovery after earthquakes
Authors: Markhvida Maryia , Baker Jack W
Published: April 2023

Large earthquakes cause widespread damage and can result in substantial direct and indirect economic losses. Previous researchers have proposed separate models for predicting region-wide direct and indirect losses due to future earthquakes; however, comprehensive simulation approaches that include both remain underdeveloped. In particular, the propagation of uncertainty along the various modeling steps has not been previously considered. This article addresses that gap by proposing a three-stage model to assess economic impacts of possible future earthquakes, consisting of regional ground motion simulation, damage and direct loss modeling, and macroeconomic recovery modeling. In this model, economic indicators such as direct asset losses and changes in economic sectors’ value added and employment are quantified. The model also captures uncertainty in the spatial distribution of earthquake shaking and damage patterns, which in turn is reflected in post-disaster economic indicators. The results show that considering uncertainty leads to a wide range of possible economic outcomes and high variance in direct and indirect losses. A cross-model sensitivity analysis is performed to evaluate the effect of different model parameters on the quantification of economic consequences.
Ultra-thin 2D bimetallic MOF nanosheets for highly sensitive and stable detection of glucose in sweat for dancer
Authors: Mao Yufei , Chen Tangchun , Hu Yifan , Son KwanJung
Published: April 2023

The measurement of glucose concentration in sweat is expected to replace the existing blood glucose detection, which realize the effective way of non-invasive monitoring of human glucose concentration in dancing. High precision glucose detection can be achieved by adjusting the electrode material of the sensor. Thus, in this work, the bimetallic organic frameworks (bi-MOFs) materials containing Mn and Ni ions (NiMn-MOF) with ultrathin nanosheets have been exquisitely designed. The ultrathin nanosheet and heterogeneous metal ions in the structure optimize the electronic structure, which improves the electrical conductivity of MOFs. The success of the preparation strategy leads the good electrocatalytic performance of NiMn-MOF for glucose detection. Detailedly, NiMn-MOF shows high sensitivity of 1576 μA mM−1 cm−2 in the linear range from 0 to 0.205 mM and the wide linear region of 0.255–2.655 mM and 3.655–5.655 mM were also observed. In addition, the high repeatability, reproductivity, long-term stability and ultra-low limited of detection (LOD, 0.28 μM, S/N = 3) provide foundation for the practical sensor application of this NiMn-MOF nanosheets. Remarkably, as designed NiMn-MOF sensor can accurately measure glucose in sweat showing great potential in the field of wearable glucose monitoring during dancing.
Quantitative proteomics analysis in small cell carcinoma of cervix reveals novel therapeutic targets
Authors: Qiu Haifeng , Su Ning , Wang Jing , Yan Shuping , Li Jing
Published: April 2023

Background

As a rare pathologic subtype, small cell carcinoma of the cervix (SCCC) is characterized by extensive aggressiveness and resistance to current therapies. To date, our knowledge of SCCC origin and progression is limited and sometimes even controversial. Herein, we explored the whole-protein expression profiles in a panel of SCCC cases, aiming to provide more evidence for the precise diagnosis and targeting therapy.

Methods

Eighteen SCCC samples and six matched normal cervix tissues were collected from January 2013 to December 2017. Data independent acquisition mass spectrometry (DIA) was performed to discriminate the different proteins (DEPs) associated with SCCC. The expression of CDN2A and SYP in corresponding SCCC tissues was verified using immunohistochemistry. GO and KEGG enrichment analyses were used to identify the key DEPs related to SCCC development and tumor recurrence.

Results

As a result, 1311 DEPs were identified in SCCC tissues (780 up-regulated and 531 down-regulated). In up-regulated DEPs, both GO analysis and KEGG analysis showed the most enriched were related to DNA replication (including nuclear DNA replication, DNA-dependent DNA replication, and cell cycle DNA replication), indicating the prosperous proliferation in SCCC. As for the down-regulated DEPs, GO analysis showed that the most enriched functions were associated with extracellular matrix collagen-containing extracellular matrix. KEGG analysis revealed that the DEPs were enriched in Complement and coagulation cascades, proteoglycans in cancer, and focal adhesion-related pathways. Down-regulation of these proteins could enhance the mobility of cancer cells and establish a favorable microenvironment for tumor metastasis, which might be accounted for the frequent local and distant metastasis in SCCC. Surprisingly, the blood vessels and circulatory system exhibit a down-regulation in SCCC, which might be partly responsible for its resistance to anti-angiogenic regimens. In the stratification analysis of early-stage tumors, a group of enzymes involved in the cancer metabolism was discriminated in these recurrence cases.

Conclusions

Using quantitative proteomics analysis, we first reported the whole-protein expression profiles in SCCC. Significant alterations were found in proteins associated with the enhancement of DNA replication and cellular motility. Besides the association with mitosis, a unique metabolic feature was detected in cases with tumor recurrence. These findings provided novel targets for disease surveillance and treatments, which warranted further validation in the future.
The impact of bone marrow irradiation dose on acute haematologic toxicity in cervical cancer patients treated with concurrent chemoradiotherapy
Authors: Chen Min , Wang Dajiang , Bao Zhirong , Yi Zongbi , Mei Zijie , Sun Shaoxing , Xiang Qingming , Yang Chunxu , Yang Hui , Qiu Hui , Xie Conghua
Published: April 2023

Objective

To evaluate the impact of bone marrow (BM) irradiation dose on acute haematologic toxicity (HT) in concurrent chemoradiotherapy for cervical cancer.

Methods

Sixty-nine patients with cervical cancer treated with curative or postoperative adjuvant therapy received weekly cisplatin concurrent chemotherapy (CCT) and intensity-modulated radiation therapy (IMRT). The whole pelvic bone marrow (PBM) was delineated and divided into three subsites: ilium (IL), lower pelvis (LP), and lumbosacral spine (LS). Associations between clinical variables, dose volume of BM, including PBM, IL, LP, and LS in the form of x-Vy (volume receiving y Gy for x), and blood cell count nadir were tested using linear regression models. Receiver operating characteristic (ROC) curve analysis was further used to analyse the cutoff values of the variables with p < 0.05 in the multivariate analysis.

Results

In 69 patients, the haemoglobin nadir was positive correlated with baseline haemoglobin (p < 0.001), negative correlated with relative LP-V10 (p = 0.005), relative LP-V25 (p = 0.002), relative LP-V50 (p = 0.007), relative LP-mean (p = 0.003), absolute LP-V15 (p = 0.049), absolute LP-V25 (p = 0.004) and absolute LP-V30 (p = 0.009). The platelet nadir was positive correlated with baseline platelets (p = 0.048) and negative correlated with relative LP-V40 (p = 0.028), but there was no significant variable in absolute radiation volume by multivariate analysis. No variables related to the neutrophil nadir were found, and the 69 patients were divided into group A (43 cases) receiving 3–4 cycles of CCT and group B (26 cases) receiving 5–6 cycles of CCT. In group A, the relative IL-V15 (p = 0.014), the relative IL-V50 (p = 0.010) and the absolute LP-V50 (p = 0.011) were negative correlated with the neutrophil nadir. No significant variable was found in group B. No significant variables related to the lymphocyte nadir were found, and the neutrophil-to-lymphocyte ratio (NLR) was analysed. Age (p < 0.05), relative LP-V15 (p = 0.037) and absolute PBM-mean (p < 0.001) were found to be negative related to NLR.

Conclusion

The dosimetric parameters of relative irradiated volume of BM have more statistically significant datas on acute HT than absolute irradiated volume. The nadir of haemoglobin and platelets and the vertice of NLR were more affected by the irradiation dose to LP, while neutrophils were more affected by the dose to IL. Acute HT was negative related to both low-dose irradiation (V10-30) and high-dose irradiation (V40, V50). For more than 4 cycles of CCT, the effect of BM irradiation on the neutrophils nadir was masked by chemotherapy.
Correlations between 3D preoperative planning and postoperative reduction in the osteosynthesis of distal humeral fractures
Authors: Yoshii Yuichi , Iwabuchi Sho , Ikumi Akira , Kohyama Sho , Ogawa Takeshi , Ishii Tomoo
Published: April 2023

Background

Three-dimensional preoperative planning has been applied to the osteosynthesis of distal humerus fractures. The present study investigated the correlations between 3D preoperative planning and postoperative reduction for the osteosynthesis of distal humerus fractures using 3D parameters.

Methods

Twenty-three elbows of 23 distal humerus fracture patients who underwent osteosynthesis with three-dimensional preoperative planning were evaluated. 3D images of the distal humerus were created after taking preoperative CT scans of the injured elbow. Fracture reduction, implant selection, and placement simulations were performed based on 3D images. Postoperative CT images were taken 1 month after surgery. Correlations were evaluated with preoperative plans and postoperative 3D images. The longitudinal axis and coordinates of the humerus were defined on the 3D images. The coronal angle (CA) was defined as the angle formed by the long axis and the line connecting the medial and lateral margins of the trochlea of the humerus on a coronal plane image. The sagittal angle (SA) was defined as the angle formed by the long axis and the line connecting the top of the lateral epicondyle and the center of the humeral capitellum on a sagittal plane image. The axial angle (AA) was defined as the angle between the sagittal plane and the line connecting the medial and lateral margins behind the trochlea of the humerus. The intraclass correlation coefficients (ICC) of each measurement value were assessed between preoperative planning and postoperative images.

Results

Preoperative planning and postoperative measurement values were CA: 85.6 ± 5.9°/85.8 ± 5.9°, SA: 140.9 ± 8.5°/139.4 ± 7.9°, and AA: 84.0 ± 3.1°/82.6 ± 4.9°, respectively. ICCs were CA: 0.75 (P < 0.01), SA: 0.78 (P < 0.01), and AA: 0.34 (P < 0.05), respectively.

Conclusions

The 3D preoperative planning of distal humeral fractures achieved the good correlations of coronal and sagittal angles, but the relatively poor correlation of the axial angle. This may be attributed to an inability to assess the rotation angle during surgery. We propose the measurement indices shown in the present study as a three-dimensional evaluation index for distal humerus fractures.

Trial registration

Registered as NCT04349319 at ClinicalTrials.gov.