bluuebunny/crossref_metadata_2025 huggingface dataset:
Penilaian Kerentanan dan Kesiapsiagaan Bencana Tsunami di Pesisir Sadeng, Gunungkidul
Authors: Nucifera Fitria , Riasasi Widiyana , Putro Sutanto Trijuni , Marfai Muhammad Aris
Published: August 2019

Kejadian tsunami di Indonesia mencapai 5% dari total kejadian tsunami secara global. Pesisir selatan Jawa menjadi salah satu kawasan yang berpotensi tsunami karena letaknya berada pada zona subduksi. Pelabuhan perikanan pesisir Sadeng terletak di pantai pesisir Selatan Yogyakarta dengan potensi terdampak bencana tsunami. Penilaian kerentanan fisik dan sosial di pesisir Sadeng serta kesiapsiagaan masyarakat terhadap bencana tsunami menjadi tujuan dari penelitian. Metode penilaian kerentanan dan kesiapsiagaan menggunakan parameter fisik dengan indikator infrastruktur dan parameter sosial dengan indikator masyarakat. Kawasan pesisir Sadeng tergolong memiliki tingkat kerentanan yang tinggi dikarenakan posisi infrastruktur yang sangat dekat dengan garis pantai (< 50 meter) dan kondisi penduduk yang padat menjadikan kawasan ini rentan mengalami kerusakan dan kerugian ketika bencana tsunami terjadi. Dari segi kesiapsiagaan, kawasan ini telah memiliki kesiapsiagaan yang tinggi dalam menghadapi tsunami. Beberapa hal tentang kesiapsiagaan yang masih perlu untuk ditingkatkan lagi adalah tentang jalur evakuasi dan organisasi kebencanaan.Kata kunci: tsunami, kerentanan, kesiapsiagaan, pesisir, SadengTsunami occurance in Indonesia was 5% from total global tsunami worldwide. Java Southern Coast prones to tsunami because it is located in subduction zone. This made Sadeng Fishing Port, prones to tsunami because it is located in the Southern Coast of Yogjakarta. Physical and social vulnerability assessment along with community preparedness towards tsunami was the aim of this research. The vulnerability and preparedness assessment method utilized physical parameters with its infrastructure indicator and social parameter with its society indicatior. Sadeng Coastal Area categorized as high vulnerable area prone to tsuami because of their infrastructures built very close to the coastal line (<50 meters), also with dense population develop this area prone to devastation and loss due to tsunami. From the preparedness point of view, this area has a high level of preparedness in facing tsunami. Several points need to be elevated are evacuation routes and rganization of disaster management.Key words: tsunami, vulnerability, preparedness, coastal, Sadeng
Alternatif Penyelesaian Sengketa Pencemaran Limbah Industri Melalui Community Policing di Sumatera Selatan
Authors: Setiawan Rachmat , Nitibaskara TB Rommy , Koto Zulkarnaen
Published: August 2019

Saat ini terdapat banyak sengketa antara industri dan masyarakat. Sengketa ini disebabkan oleh adanya perbedaan kepentingan antara perusahaan/ industri dengan masyarakat mengenai pola pengelolaan limbah. Salah satunya terjadi di Provinsi Sumatera Selatan. Proses penyelesaian sengketa pencemaran lingkungan limbah industri yang telah terjadi hanya berdasarkan proses hukum formal. Proses formal membutuhkan waktu yang lama dan biaya yang tidak sedikit untuk menghasilkan keputusan dengan kekuatan hukum permanen. Hasil dari proses formal ini adalah juga win-lose sultion, yang dapat menghasilkan dampak ekonomi dan sosial yang signifikan baik pada perusahaan maupun pada masyarakat. Solusi alternatif untuk pencemaran perselisihan lingkungan dari air limbah industri melalui pemolisian masyarakat (community policing) merupakan kebebasan para pihak yang secara sukarela atau cara-cara lain yang sah dengan menggunakan kebijaksanaan atau kebijakan kepolisian yang bersifat sementara. Bentuk sukarela dan sementara ini tidak menyelesaikan masalah dengan tuntas. Penyelesaian alternatif melalui pemolisian masyarakat akan menghasilkan win-win solution, yang akan memberikan kesepakatan yang saling menguntungkan antara para pihak.Kata Kunci: Penyelesaian Sengketa, Limbah Industri, Pencemaran Air, Communnity Policing, Provinsi Sumatera SelatanAt present there are many industrial disputes between companies and the public. This dispute is due to the perspective of different interests between companies and communities regarding waste management patterns. One of the cases in South Sumatera is the dispute of industrial water pollution in the community.The process of dispute resolution of environmental pollution of industrial wastewater that has been happening is only based on formal legal process. The formal process takes a long time and costs are not small to produce decisions with permanent legal force. The result of this formal process is also win-Lose sultion, which can result in significant economic and social impacts both in company and community. Alternative solutions to environmental dispute pollution of industrial wastewater through communinty policing, which is the freedom of the parties that are voluntary or other ways lawful by using discretion or policing policies that are temporary. This voluntary and temporary form does not solve the problem thoroughly. Alternative settlement through community policing will result in a win-win solution, which will provide a mutually beneficial agreement between the parties.Keywords: Disputes Resolution, Industrial Waste, Water Pollution, Community Policing, South Sumatera Province
Kajian Pemetaan Struktur dan Potensi Longsor Berdasarkan Digital Elevation Model dan Unmanned Aerial Vehicle (UAV), Daerah Pangkalan, Sumatera Barat
Authors: Choanji Tiggi , Yuskar Yuniarti , Cahyaningsih Catur
Published: August 2019

Bencana geologi berupa tanah longsor telah terjadi di beberapa tempat terutama pada jalur lintas Riau - Sumatra Barat tepatnya pada daerah pangkalan, Pangkalan Koto Baru dan sekitarnya. Penelitian ini bertujuan untuk membahas geologi struktur dan geologi kebencanaan untuk penentuan pola struktur, faktor utama terjadinya longsor dalam bentuk peta rawan bencana. Dengan menggunakan data foto udara dengan drone dan data geologi lapangan, serta dilakukan analisis diantaranya analisis foto udara, geologi struktur dengan menggunakan stereografi, analisis geologi keteknikan dengan sistem RMR (Rock Mass Rating). Hasil memperlihatkan bahwa berdasarkan 1.496 data kekar yang diambil dari 14 (empat belas) titik stasiun didapatkan beberapa arah dominan gaya yang mempengaruhi daerah tersebut, hal ini disebabkan oleh periode tektonik pra tersier dan tersier di Sumatra Tengah yang ditunjukkan dengan tegasan yang bekerja memiliki tiga arah dominan  yang terekam dalam pembentukan struktur di daerah ini, yaitu tegasan bearah Utara “ Selatan , Timurlaut “ Baratdaya, dan Baratlaut “ tenggara. Berdasarkan analisis geologi teknik dengan menggunakan metode RMR, terdapat kluster 1 (satu) titik yang berada dalam kategori very poor (Kategori Klas V), 12 (duabelas) titik dalam kategori poor rock (Kategori Klas IV), dan 1 titik pada keadaan medium rock  (Kategori Klas III).Kata kunci: Struktur geologi, Longsor, DEM, Rock Mass Rating, UAV, Pangkalan.Geological disasters of landslides have occurred in several locations in Riau - West Sumatra Road, Pangkalan Koto Baru and its surroundings. This study aims to discuss disaster geological structure and geology to determine structural patterns, the main mitigation factor in disaster-prone map. By using aerial photo data with drones, field geological data, the aerial photograph analyze using dense cloud analysis, structural geology using stereography, engineering geological analysis with the RMR (Rock Mass Rating) system. The results based on 1,496 solid data which obtained from 14 (fourteen) station points suggested that several dominant stress directions affect the area, which is derived from the pre-tertiary and tertiary tectonic periods in Central Sumatra. Structure are trending North - South, Northeast - Southwest, and Northwest - southeast. The RMR method, showed that there are 1 (one) cluster in the very bad category (Class V category), 12 (twelve) points in poor rock category (Class IV category), and 1 (one) in medium condition (Class III category).Key words: Structural Geology, Landslides, DEM, Rock Mass Rating, UAV, Pangkalan.
Makna Berpikir Spasial Masyarakat Minangkabau Dalam Logo Pemerintahan Daerah di Sumatera Barat
Authors: Aliman Muhammad , Marni Silvia , Budijanto Budijanto , Sumarmi Sumarmi , Astina I Komang
Published: August 2019

Tujuan penelitian ini memberikan deskripsi tentang makna yang terkandung dari tanda dan simbol pada logo pemerintahan daerah di Propinsi Sumatera Barat. Metode deskriptif  kualitatif digunakan untuk mengkaji tema pada artikel ini dengan pendekatan semiotik. Pendekatan semiotik yang digunakan adalah analisis denotasi dan konotasi. Logo pemerintahan daerah yang dijadikan subjek penelitian mewakili daerah kepulauan, daerah pesisir, daerah dataran rendah dan daerah dataran tinggi. Unsur spasial untuk menganalisis makna logo menggunakan unsur spasial menurut Sharpe dan Huynh. Hasil penelitian menjelaskan makna yang terkandung pada logo pemerintahan daerah berasal dari kearifan lokal masyarakat setempat yang mewakili berbagai elemen fisik maupun non fisik. Salah satu makna yang terkandung adalah elemen fisik berupa unsur spasial. Hal ini menjelaskan bahwa pemikiran masyarakat Minangkabau sejak dahulu berasal dari unsur-unsur spasial dalam kehidupannya. Makna pada logo pemerintahan daerah perlu diungkapkan secara terbuka agar masyarakat dan pegawai pemerintahan dapat mengetahui dan memahami serta memaknainya sebagai kekayaan kearifan lokal yang harus dijaga, diamalkan dan dilestarikan.The purpose of this research is to provide a description of the meaning contained in signs and symbols on the logo of regional government in West Sumatra Province. Qualitative descriptive method is used to examine the theme in this article with a semiotic approach. The semiotic approach used is the analysis of denotations and connotations. The logo of the regional government that was used as the research subject represented islands, coastal areas, lowland areas and highland areas. Spatial elements to analyze the meaning of logos using spatial elements according to Sharpe and Huynh. The results of the study explain the meaning contained in the logo of regional government derived from the local wisdom of the local community which represents various physical and non-physical elements. One of the meanings contained is a physical element in the form of spatial elements. This explains that the thinking of the Minangkabau community has long been derived from spatial elements in his life. The meaning of the logo of regional government needs to be disclosed openly so that the public and government employees can know and understand and interpret it as a wealth of local wisdom that must be maintained, practiced and preserved.
Analisis Dampak Pembangunan Infrastruktur Bandara Internasional Jawa Barat Terhadap Alih Fungsi Lahan Pertanian Melalui Citra Satelit Resolusi Tinggi
Authors: Sari Nurwita Mustika , Kushardono Dony
Published: August 2019

Pembangunan infrastruktur seperti bandara akan menyebabkan perubahan penggunaan lahan pada area tersebut dan sekitarnya. Perubahan ini, terutama jika wilayah bandara berada pada wilayah yang dominan dengan lahan pertanian maka akan berpotensi mengubah fungsi lahan pertanian tersebut menjadi lahan non pertanian. Pembangunan infrastruktur bandara termasuk aksesnya akan mendorong pertumbuhan wilayah dan pertumbuhan ekonomi di wilayah tersebut. Tujuan penelitian ini adalah mendeteksi perubahan penggunaan lahan di wilayah Bandara Internasional Jawa Barat (BIJB) Kertajati khususnya alih fungsi lahan pertanian ke non pertanian. Metode yang diusulkan dalam penelitian ini adalah mengidentifikasi perubahan penggunaan lahan pada area kajian menggunakan data SPOT multitemporal dimana dilakukan klasifikasi perpaduan antara segmentasi objek secara digital menggunakan metode multiresolution segmentation dan penentuan kelas penggunaan lahan secara visual. Hasil penelitian menunjukkan bahwa telah terjadi penurunan luasan sejak 2013 hingga 2018 di wilayah kajian yaitu dari 5.822,80 ha pada tahun 2013 menjadi 5.347,30 ha selama kurun waktu 2013-2018. Kata kunci: penginderaan jauh, perubahan penggunaan lahan, pembangunan infrastrukturThe construction of infrastructure such as airport will cause changes in land use in the area and its surroundings. This change, especially if the airport area is in the dominant area with agricultural land or ricefield, will potentially change the function of the ricefield into non-agricultural land. The construction of airport infrastructure, including its access, will drive regional growth and economic growth in the region. The purpose of this research is to detect changes of land use in the West Java International Airport (BIJB) Kertajati region, West Java, especially the conversion of ricefield to non-agricultural land. The method proposed in this study is to identify changes of land use in the study area using multitemporal SPOT data where the hybrid classification is done with digital object segmentation method using multiresolution segmentation and the determination of land use classes with visual interpretation. The result shows that there had been a decrease in the area of ricefield from 5,822.80 hectares in 2013 became 5,347.30 hectares during the period 2013-2018.Keyword: remote sensing, land-use change, infrastructure development
DAMPAK PERKEMBANGAN KAMPUNG INGGRIS TERHADAP PERUBAHAN SOSIAL DAN BUDAYA MASYARAKAT DESA PELEM DAN DESA TULUNGREJO PARE-KEDIRI JAWA TIMUR
Authors: Handoko Putut
Published: August 2019

An English Kampong is a community dwelled by many Courses and the new comers form many regions in Indonesia in order to study Englih. The image of the village of  Pelem and Tulungrejo as English kampong have attracted many youth from many regions to study English. English kampong was established in 1977. The fast growing English kampong is identified by the establishment of many courses and the arrival of new comers from regions in Indonesia in order to studyEnglish. They stay at homestay and English Camp. The fast growing English  Kampong effects social and cultural change toward the society of the village ofPelem especially Singgahan Kampong and the village of Tulungrejo  especially Mangunrejo Kampong Pare Kediri East Java.The effect of the fast growing English Kampung toward social change cov ers  1) the change seen from social value, 2) the change seen from social attitude, and 3) the change seen from social behaviour. The effect of the fast growing English Kampong toward cultural change covers 1) the change seen fromcultural tardition aspect, 2) the change seen from science aspect, 3) the change seen from of technology aspect, 4) the change seen from belief aspect.
Dobrobyt społeczny w świetle ekonomii szczęścia na przykładzie wybranych państw Unii Europejskiej
Authors: Wachowiak Artur , Kowalczyk Kamil
Published: August 2019

Motywacja: Jednym z podstawowych problemów makroekonomii jest kwestia dobrobytu społeczeństw. W przeszłości, znacząca część ekonomistów zwykła utożsamiać wielkość gospodarki, bądź dynamikę jej wzrostu, ze stopą życiową. Obecnie, ocena dobrobytu społeczeństwa sprowadza się do oceny jakości życia w danym państwie. W głównym nurcie rozważań makroekonomicznych przyjęło się posługiwanie miarą jaką jest Produkt Krajowy Brutto (PKB) wraz z jej pochodnymi. Niestety wskaźniki te nie obejmują wielu kluczowych czynników wpływających na poziom dobrobytu. Z tego powodu na przestrzeni lat zastosowano nowe, szersze podejście i opracowano nowe mierniki takie, jak np. Wskaźnik Rozwoju Społecznego (Human Development Index, HDI). Koniecznym wydaje się rozważenie ich wartości poznawczej w kontekście współczesnego dorobku ekonomii szczęścia. W tym celu dokonano przeglądu najpopularniejszych wskaźników dobrobytu i jakości życia oraz skonfrontowano je z pozaekonomicznymi danymi opisującymi procesy zachodzące w społeczeństwach, zwracając szczególną uwagę na różnice interpretacyjne i możliwe odmienne oceny.
Cel: Celem jest ocena pomiaru jakości stopy życiowej, przez przegląd dostępnych rozwiązań i metod oraz konfrontacja wyników z danymi publicznych statystyk wybranych państw Unii Europejskiej (UE).
Materiały i metody: Wykorzystano przegląd systematyczny i analizę krytyczną literatury, analiza zagregowanych danych makroekonomicznych oraz statystyki publicznej. Materiał empiryczny stanowią dane publikowane przez Eurostat, Organizację Współpracy Gospodarczej i Rozwoju (Organisation for Economic Co-operation and Development, OECD), Światową Organizację Zdrowia (World Health Organization, WHO) oraz Bank Światowy (World Bank).
Wyniki: Istnieją istotne różnice w ocenie jakości życia między wskaźnikami przyjętymi w głównym dyskursie ekonomicznym a empirycznymi danymi z innych nauk, tj. społecznych czy medycznych.
Regional Polymorphism Assessment of Myanmar ‘Sein Ta Lone’ Mango (Mangifera indica Linn) from Sintgaing Township Based on Microsatellite Markers
Authors: Kyaing May Sandar , May Phyo Sein Sandar
Published: August 2019

This study was conducted to explore the genetic diversity and relationship of Sein Ta Lone mango cultivars among 20 commercial orchards in Sintgaing Township, Mandalay region. Nine microsatellite (SSR) markers were used to detect genetic polymorphism in a range from (3 to 6) alleles with (4.33) alleles per marker in average. Six out of nine microsatellite markers gave the PIC values of greater than (0.5). Among them, SSR36 held the highest PIC values of (0.691) while MiSHRS39 and MN85 possessed the least PIC values of (0.368) and (0.387) respectively. The genetic diversity was expressed as unbiased expected heterozygosity (UHe) value with an average of (0.561). The genetic relationship was revealed by (UPGMA) dendrogram in a range of (0.69 to 1.00). Based on UPGMA cluster analysis, three main clusters were classified among three different locations. This study was intended to help cultivar characterization and conservation for proper germplasm management with the estimation of genetic variation and relationship in the existing population of Sein Ta Lone mangoes in Sintgaing Township by microsatellite markers.
Anomalous geothermal gradients and heat flow in the Limpopo Province, South Africa: Implications for geothermal energy exploration
Authors: Jones M.Q.W.
Published: August 2019

The crustal rocks of South Africa are generally regarded as too old and cold for utilisation of geothermal energy. However, demands for alternative energy and the introduction of new technology have instigated a number of research projects in this and surrounding countries. Higher than average heat flow and the occurrence of several thermal springs in the northern Limpopo Province suggest that this region is a potential target area. Geothermal measurements in the eastern part of the Province yield anomalously high rock temperatures, thermal gradients (up to 90 K/km) and heat flow (up to 200 mW m-2). The anomalies are attributed to deep-seated circulation of meteoric water that provides an effective mechanism for concentrating geothermal heat. Heat flow studies of this kind may reveal more extensive potential geothermal fields elsewhere in South Africa.
Individuals With and Without Low Back Pain Use Different Motor Control Strategies to Achieve Spinal Stiffness During the Prone Instability Test
Authors: Sung Won , Hicks Gregory E. , Ebaugh David , Smith Susan S. , Stackhouse Scott , Wattananon Peemongkon , Silfies Sheri P.
Published: August 2019

Background

The prone instability test is used to identify individuals with low back pain (LBP) who would benefit from trunk stabilization exercises. Although activity from muscles during the leg-raising portion of the prone instability test theoretically enhances spinal stiffness and reduces pain, evidence for this is lacking.

Objectives

To compare and contrast (1) pain and stiffness changes between prone instability testing positions, and (2) muscle activation patterns during the prone instability test leg raise in individuals with and without LBP.

Methods

Participants with (n = 10) and without (n = 10) LBP participated in this laboratory case-control study. Spinal stiffness was measured using a beam-bending model and 3-D kinematic data. Stiffness changes were compared across the test positions and between groups. Surface electromyographic data were collected on trunk and limb musculature. Principal-component analysis was used to extract muscle synergies.

Results

Spinal stiffness increased across testing positions in all participants (P<.05). Participants with LBP experienced reduced pain during the test (P<.001). No between-group difference was found in spinal stiffness during leg raising during the test (P>.05). Participants without LBP used 3 muscle synergies during the leg raise and participants with LBP used 2 muscle synergies.

Conclusion

Spinal stiffness increased in all participants; however, participants without LBP demonstrated a muscle synergy pattern where each synergy was associated with a distinct function of the prone instability test. Participants with LBP used a more global stabilization pattern, which may reflect a maladaptive method of enhancing spinal stability. J Orthop Sports Phys Ther 2019;49(12):899–907. Epub 3 Aug 2019. doi:10.2519/jospt.2019.8577
Development of the University of Wisconsin Running Injury and Recovery Index
Authors: Nelson Evan O. , Ryan Michael , AufderHeide Erin , Heiderscheit Bryan
Published: August 2019

Background

Runners experience a high proportion of overuse injuries, with extended recovery periods involving a gradual, progressive return to preinjury status. A running-specific patient-reported outcome (PRO) measure does not exist, and a questionnaire assessing critical elements of runners' recovery processes may have excellent psychometric properties.

Objectives

To develop a valid, reliable, and responsive evaluative PRO measure to assess longitudinal change in running ability after running-related injury (RRI) for clinical practice and research applications.

Methods

Self-identified runners and selected experts participated in an iterative, 6-step development process of the University of Wisconsin Running Injury and Recovery Index (UWRI) in this longitudinal clinical measurement study. Content-related validity was assessed using open comments. Reproducibility was assessed using Cronbach's alpha, the intraclass correlation coefficient (ICC), and standard error of measurement (SEM). An anchor-based construct validity assessment measured the association between the change in UWRI score and global rating of change (GROC). Responsiveness assessments included floor and ceiling effects.

Results

The 9-item UWRI assesses running ability following an RRI, with the maximum score of 36 indicating a return to preinjury running ability. The UWRI demonstrated acceptable internal consistency (α = .82), test-retest reliability (ICC = 0.93), and SEM (1.47 points). Change in UWRI score was moderately correlated with the GROC (r = 0.61; 95% confidence interval: 0.4, 0.76). Floor and ceiling effects were absent. Completion required 3 minutes 15 seconds.

Conclusion

The UWRI is a reliable PRO measure and is responsive to changes in running function following an RRI, with minimal administrative burden.

Level of Evidence

Therapy, level 2c. J Orthop Sports Phys Ther 2019;49(10):751–760. Epub 3 Aug 2019. doi:10.2519/jospt.2019.8868
Circulating microRNAs as potential biomarkers of chronic kidney disease
Authors: Aitbaev K. A , Murkamilov I. T , Fomin V. V
Published: August 2019

Chronic kidney disease (CKD) is a supra - nosological term that reflects the progressive nature of chronic kidney diseases, which are based on the mechanisms of nephrosclerosis. Diagnosis of CKD at the earliest stages is of great importance, because it allows, by using therapeutic agents, to slow the progression of renal dysfunction and the development of cardiovascular complications. However, the currently available methods for diagnosing renal function impairment, including the determination of endogenous creatinine clearance, can detect renal dysfunction too late, when around 40-50% of the renal parenchyma is already reversibly or irreversibly damaged. In this regard, there is an active search for new, more sensitive and specific biomarkers for early diagnosis of CKD. Recent studies in cellular and animal models of CKD have demonstrated the important role of microRNA, a new class of posttranscriptional regulators of gene expression, in physiology and pathophysiology of kidneys. In particular, it has been shown that their expression profile in blood or urine can reflect changes in cells involved in a particular pathological process, since these cells can secrete a specific population of microRNAs, for example, through secretion of microRNA-containing exosomes. This gave grounds for considering increased or decreased expression of individual microRNAs in renal tissue or biological fluids (including urine) as new biomarkers for the diagnosis and monitoring of CKD. This review presents the results of recent experimental and clinical studies on these issues.
The relationship of hypertriglyceridemia and left ventricular remodeling types in patients with chronic kidney disease
Authors: Murkamilov I. T , Sabirov I. S , Fomin V. V , Aitbaev K. A , Murkamilova Zh. A
Published: August 2019

Aim. To assess the relationship between hypertriglyceridemia (THG) and left ventricular remodeling types in patients with chronic kidney disease(CKD). Materials and methods. A total of 152 patients with CKD from stages 1 to 3 were examined, 98 of them with CKD without THG (subgroup 1) and 54 with CKD and THG. All patients were assessed for the parameters of anthropometry, hemodynamics, lipid spectrum, uric acid, calcium, C-reactive protein (CRP), and serum cystatin C measurement with calculation of glomerular filtration rate. The parameters of vascular stiffness (augmentation index and stiffness) and echocardiography are analyzed. Results and discussion. In the 2nd subgroup (CKD + THG), the number of patients suffering from type 2 diabetes, a stable form of coronary heart disease, gout, and their combination with hypertension, as well as cerebrovacular disorders and hyperuricemia was significantly higher compared with patients with CKD without GTG (p
Polyvascular disease in patients with myocardial infarction and chronic kidney disease
Authors: Karetnikova V. N , Kalaeva V. V , Evseeva M. V , Gruzdeva O. V , Zykov M. V , Kashtalap V. V , Barbarash O. L
Published: August 2019

Aim. To study polyvascular disease in patients with myocardial infarction (MI) and chronic kidney disease (CKD). Materials and methods. A total of 954 patients older than 18 years old with ST-segment elevation MI (STEMI) up to 24 hours of pain onset were included in the study. Clinical and demographic data were collected for all patients, including physical examination, 16-lead electrocardiogram recording, echocardiography, laboratory assessment with the measurements of cardiospecific enzymes and serum creatinine. Glomerular filtration rate (GFR) was estimated according to the CKD-EPI equation. Of them, 771 (81%) underwent coronary angiography, duplex scanning of the brachiocephalic (BCA) and lower extremity arteries (LEA). Patients with stage 1-4 CKD diagnosed according to the criteria provided by the Russian Society of Nephrologists were allocated into a separate group (n=281; 36.5%). CKD stages were determined with the level of GFR. Patients with stage 5 CKD were excluded from the study. Renal dysfunction was defined as the presence of an estimated GFR less than 60 ml/min/1.73 m2. Results and discussion. The results of the study indicate a high prevalence of PolyVD in patients with CKD. Every second patient had LEA stenosis (p
Factors associated with a reduction in glomerular filtration rate in patients with chronic obstructive pulmonary disease
Authors: Bolotova E. V , Dudnikova A. V
Published: August 2019

Aim. Analysis of factors associated with reduced glomerular filtration rate (GFR) in patients with chronic obstructive pulmonary disease (COPD). Materials and methods. The study included 198 patients with COPD 1-4 degrees of severity (GOLD 2014), who were on examination and treatment in Krasnodar Regional clinical hospital № 2. The control group consisted of 28 healthy volunteers, comparable in age and sex. In addition to clinical research, all patients, we calculated GFR according to the formula CKD-EPI based on cystatin C serum (GFRcys). The contribution of the factors in the risk of developing CKD was determined using multivariate linear regression analysis, as dependent variable used the value of GFRcys. Results and discussion. It was found that more than half (51.5%) of patients with COPD have a decrease in GFRcys
Protein - energy wasting of haemodialysis patients
Authors: Jakovenko A. A , Rumyantsev A. Sh
Published: August 2019

Aim. To assess the prevalence of protein - energy wasting (PEW) of haemodialysis patients (HD). Materials and methods. A total of 645 patients receiving treatment with programmatic bicarbonate HD for 8.4±5.3 years, including 345 women and 300 men, the average age was 56.8±12.8 years. Nutritional status was assessed using the method recommended by the Ministry of Health of the Russian Federation (MHRF) (accounting form № 003/U), as well as the method proposed by the International Society of Renal Nutrition and Metabolism (ISRNM). The nature of the change in appetite was determined by the Appetite and diet assessment tool (ADAT) and KDQOL-SF (version 1.3). Evaluation of the adequacy of the diet was performed using filled in patients for 3 days food diaries. Results and discussion. A decrease in appetite was recorded in no more than 5% of patients, while these changes were of a persistent, lasting nature. Inadequate intake of essential nutrients, taking into account the recommendations of the ERBP, was found in 9.7% of patients, while inadequate intake of protein was noted. The prevalence of PEW by the method of MHRF was 75.3%, by the method of ISRNM the prevalence of PEW was 51.2%. There were no statistically significant differences between the patient groups depending on age and the presence of PEW according to the MHRF method (χ2=7.072; p=0.069). Similar data were obtained for the method of diagnostics PEW ISRNM. Statistically significant differences between groups of patients were obtained depending on the duration of HD and the presence of PEW according to the MHRF method (χ2=22.580; r=0.0001). The prevalence of PEW by the MHRF method increases with increasing duration of HD (Rs=0.184; p=0.0001). Similar data were obtained for the method of diagnosis of PEW ISRNM. Conclusion. The prevalence of PEW in haemodialysis patients was 51.2% according to the ISRNM method and 75.3% according to the MHRF method.
Chronic kidney disease in the context of toxic effects the working chemical factors (literature review)
Authors: Strizhakov L. A , Fomin V. V , Garipova R. V , Babanov S. A , Arkhipov E. V , Lebedeva M. V
Published: August 2019

The article analyzes the publications devoted to the problem of professional renal lesions caused by chemical factors. Classification, prevalence, peculiarities of the clinical picture, diagnosis of professional renal lesions caused by chemical factors of the production environment are reviewed. The frequency of professional renal lesions remains underestimated due to low manifestation of symptoms and the influence of environmental factors, which require further investigation of this issue.
Difficulties in diagnosing the syndrome of "aorto - mesenteric tweezers" (nutcracker syndrome) in a patient with macrogematuria
Authors: Grigoryeva E. V , Senichkina M. N , Maiorova A. A , Kiseleva O. A
Published: August 2019

The clinical observation of a patient with a rare pathology - "nutcracker syndrome". Difficulties of diagnosis verification are described.
Diagnosis and treatment of myocardial infarction in patient with end - stage renal disease on chronic hemodialysis
Authors: Antukh D. E , Shchekochikhin D. Yu , Nesterov A. P , Gilarov M. Yu
Published: August 2019

This review represents different aspects of myocardial infarction in patient with end - stage renal disease on chronic hemodialysis. We discuss difficulties in diagnosis, optimal method of coronary revascularization, timing of hemodialysis session, medical therapy, as well as epidemiology and prognosis. There are no unambiguous answers to these problems because patients with end - stage renal disease were excluded from most of the studies.
Burden, access, and disparities in kidney disease
Authors: Crews Deidra C. , Bello Aminu K. , Saadi Gamal
Published: August 2019

For the World Kidney Day Steering Committee Kidney disease is a global public health problem that affects more than 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. Although the magnitude and impact of kidney disease is better defined in developed countries, emerging evidence suggests that developing countries have a similar or even greater kidney disease burden. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors, leading to significant disparities in disease burden, even in developed countries. These disparities exist across the spectrum of kidney disease - from preventive efforts to curb development of acute kidney injury or chronic kidney disease, to screening for kidney disease among persons at high risk, to access to subspecialty care and treatment of kidney failure with renal replacement therapy. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. In this editorial, we highlight these disparities and emphasize the role of public policies and organizational structures in addressing them. We outline opportunities to improve our understanding of disparities in kidney disease, the best ways for them to be addressed, and how to streamline efforts toward achieving kidney health equity across the globe.
Low protein diet with essential amino acids ketoanalogues combination can affect serum FGF-23 and Klotho levels in chronic kidney disease 3b-4 stages patients: randomized pilot study
Authors: Milovanova L. Yu , Kozlovskaya(Lysenko) L. V , Androsova T. V , Lebedeva M. V , Taranova M. V , Milovanova S. Yu , Kondratyeva T. B , Zubacheva D. O , Tchebotareva N. V , Kozlov V. V , Kuchieva A. M , Li O. A , Reshetnikov V. A
Published: August 2019

Protein restriction diet (PRD) with ketoanalagues of essential amino acids (KA) combination can improve of chronic kidney disease (CKD) course while, the precise mechanisms of PRD + KAA action in CKD are not known yet. We have conducted a prospective, randomized, controlled study of PRD and KAA patient’s group in compare with PRD without KAA group in regarding to serum Klotho and FGF-23 levels in patients with CKD. Materials and methods. The study included 79 CKD 3b-4 stages patients, non - diabetic etiology, used PRD (0.6 g/kg/day). The patients were randomized in two groups: 42 patients, received PRD + KAA (Group 1) and 37 patients continued the PRD without KAA (Group 2). Serum FGF-23 (Human FGF-23 ELISA kit with antibodies to native FGF-23 molecule, Merk Millipore MILLENZFGF-23-32K), Klotho (Human soluble Klotho with antiKlotho monoclonal antibodies, IBL-Takara 27998-96Well) levels, as well as instrumental examination: bioimpedance analysis [assess of muscle body mass (MBM), fat body mass (FBM), body mass index (BMI) and others]; sphygmography [assess of augmentation (stiffness) indices (AI), central (aortal) blood pressure (CBP) by «Sphygmacor» device]; as well as echocardiography [assess of cardiac (valvular) calcification score (CCS) and left ventricular myocardium mass index (LVMMI)], were studded in addition to conventional examination. Results and discussion. To the end of 14th month of the study the PRD group reached a body mass index (BMI) decrease (p=0.046), including MBM in men (p=0.027) and woman (p=0.044). In addition, higher FGF-23 (p=0.029), and lower Klotho (p=0.037) serum levels were revealed in the PRD group compared to the PRD+KAA group as well as the increase in AI (p=0.034), CCS (p=0.048), and LVMMI (p=0.023). Conclusion. Use of PRD + KAA provides adequate nutrition status and more efficient correction of FGF-23 and Klotho imbalance in CKD progression that may contribute to alleviation of both cardiovascular calcification and cardiac remodeling in CKD. Importantly, a prolonged PRD use without supplementation of KAA may lead to malnutrition signs.
Serum troponin-I as a marker of fibroblast growth factor-23 (FGF-23) cardiotoxic effect, in patients with chronic kidney disease
Authors: Taranova M. V , Milovanova L. Yu , Kozlovskaya(Lysenko) L. V , Milovanova S. Yu , Androsova T. V , Zubacheva D. O , Lebedeva M. V , Dobrosmyslov I. A , Kozlov V. V , Kuchieva A. M , Li O. A , Reshetnikov V. A
Published: August 2019

Aim. It has been established that an increased fibroblast growth factor (FGF-23) serum levels significantly contribute to the heart and blood vessels remodeling in patients with chronic kidney disease (CKD). But the precise mechanisms of the FGF-23 cardiac effect are currently being actively studied. At the same time, it is believed that the cardiac effects of FGF-23 may be due to the increasing deficit of Klotho protein as CKD progresses. In parallel with these changes, a number of studies indicate the persistence of the detectable troponins serum levels in CKD patients, even in the absence of clear clinical manifestations of cardiovascular diseases (CVD). The aim of the study was to confirm / exclude the existence of a causal relationship between elevated FGF-23, reduced Klotho and elevated troponin-I (as the most specific troponin in CKD). Materials and methods. The study included 130 CKD stages 1-5D patients without clinically pronounced symptoms of СVD (Coronary artery disease, CCS class 2-4, Chronic heart failure, NYHA 24, myocarditis, pericarditis, arrhythmias), as well as the severe arterial hypertension (BP >160/90 mm Hg), according to the laboratory and instrumental methods of examination. The selected group of patients was studied: serum levels of FGF-23 (Human FGF-23 ELISA kit), Klotho (Human soluble Klotho with antiklotho monoclonal antibodies), troponin-I (high - sensitive assay), and also data from instrumental examination methods: electrocardiography (ECG), echocardiography (left ventricular myocardial mass index (LVMI), cardiac (valvular) calcification score (CCS) using a semi - quantitative point scale), sphygmagraphy (augmentation (stiffness) indices of vessels (AI), pulse wave velocity (PWV), central (aortic) blood pressure (CBP), blood supply of subendocardium (BSE) - using "Shygmacor" device (Australia)). Results and discussion. The changes in serum levels of FGF-23, Klotho and troponin-I (Tr-I) depended on the stage of CKD. The following correlations were identified: FGF-23 and: Tr-I (r=0.601; p
Hepatitis C virus - related cryoglobulinemic vasculitis with renal involvement current possibilities of diagnostic and treatment
Authors: Milovanova S. Yu , Kozlovskaya(Lysenko) L. V , Milovanova L. Yu , Gordovskaya N. B , Ignatova T. M , Taranova M. V , Androsova T. V
Published: August 2019

The extrahepatic manifestations of HCV infections, which include mixed cryoglobulinemia (MC), are important for prognosis and determination of the treatment options of these patients. Currently, mixed MC type II is considered as a specific marker of chronic HCV infection. Kidney damage is one of the severe, often determining a prognosis of extrahepatic manifestation of HCV-associated cryoglobulinemic vasculitis. The review discusses the current diagnostic approaches to cryoglobulinemic GN, as well as perspectives for improving antiviral and pathogenetic therapy.
Clinical and pathologic features of nephropathy with C1q deposits
Authors: Chebotareva N. V , Vinogradov A. A , Grishina A. N , Kozlovskaya(Lysenko) L. V , Varshavsky V. A
Published: August 2019

Aim. To determine the frequency, clinical and morphological features of a nephropathy with C1q deposits in chronic glomerulonephritis adult patients. Materials and methods. 296 specimens of kidneys of patients with a chronic glomerulonephritis (CGN) from 2014 for 2018 were analyzed. At the first step, specimens with C1q deposits in glomeruli revealed by immunofluorescent method were chosen. Lupus nephritis and primary membranoproliferative glomerulonephritis were exclusion criteria. At the second step, the retrospective analysis of the clinical characteristics was carried out. Results and discussion. Deposits of C1q in kidneys at 12 of 296 (4.05%) CGN were revealed, m:f ratio 2:1. Average age of the beginning of a disease was 32.1±14.7 years. At a morphological research in 8 membranous nephropathy (MN), in 2 mesangioproliferative glomerulonephritis (MesPGN), in 2 - nephrosclerosis was revealed. Among 12 patients in 5 the disease debuted a nephrotic syndrome, at the others - a proteinuria from 0.5 to 4.0 g/days with the subsequent formation of a nephrotic syndrome. In 5 of 12 patients the disease was characterized by a favor course with preserved kidney function. At 7 patients at the time of inspection decrease in function of kidneys [glomerular filtration rate (eGFR) 31 (30-34) ml/min] was noted. 5 had slow progressing of a renal failure. 2 of 12 progressed to renal failure (eGFR to 19 and 24 ml/min) within a year. Conclusion. Deposits of C1q in kidney were revealed in 4.05% of biopsy specimens in CGN. The most frequent morphological form was the membranous nephropathy. The clinical course was characterized by a nephrotic syndrome, more than at a half of patients - with renal dysfunction.
Modern approaches to the detection of monoclonal gammopathy of undetermined significance (MGUS) in patients with kidney diseases
Authors: Kozlovskaya(Lysenko) L. V , Chebotareva N. V , Mrykhin N. N , Rameev V. V , Androsova T. V , Roshchupkina S. V , Maryina S. A , Kogarko I. N , Kogarko B. S
Published: August 2019

Monoclonal gammopathy (MG) is not only the state preceding of hematological neoplasms, but also associated with non - hematological diseases, in particular kidney damage. Aim. To assess the diagnostic value of “Freelite” methods in addition to electrophoresis (EF) and immunofixation (IF) of serum and urine proteins for detecting MG in patients with kidney diseases. Materials and methods. 87 patients with kidney damage, in which MG was established using the method of electrophoresis of serum proteins (EF), immunofixation (IF) and the method of free light chains determination - FLC “Freelite” were selected. The diagnostic value of three - component serum panel was compared with EF and IF. Results and discussion. AL-amyloidosis with kidney involvement was diagnosed in 41% patients, cryoglobulinemic glomerulonephritis (cryo GN) - in 18%, chronic glomerulonephritis (CGN) - in 35%, also there was small number of patients with light chain disease and cast - nephropathy. Determination of MG using EP was possible only in 38 (44%). Adding to the serum electrophoretic methods instead of the “Freelite” method, the urine EF and IF reduced the number of missed patients with monoclonal gammopathy from 24 (27%) to 11 (13%), including in the subgroup of patients with AL-amyloidosis but did not reach the sensitivity of the three - component serum screening panel. In 10 (11.5%) MG was represented only by intact mIg with one type of light chain, either κ or λ. Most often - in 25% of patients, intact monoclonal gammopathy was observed in HCV (+) cryo GN. A combination of intact mIgM, mIgG or mIgA with mFLC, was detected in 37 (42.5%). In almost half (46%) of the patients, only mFLC was detected - an abnormal κ/λ ratio. Conclusion: The serum screening panel EF + IF + “Freelite” spreads the low - grade monoclonal gammopathy recognition (MGUS) and should be included in the algorithm of examining patients with kidney disease.
The evolution of myocardial infarction treatment over the past decades. The significance of E.I. Chazov works
Authors: Shakhnovich R. M , Ruda M. Ya
Published: August 2019

The review is a brief historical insight into the study of myocardial infarction, in which the main discoveries are analyzed that have played an important role in improving the diagnosis and treatment of the disease. A special place in the review is occupied by the work of the outstanding cardiologist and health care organizer E.I. Chazov. More than the half - age, E.I. Chazov investigated various aspects of myocardial infarction, organized a system of medical care for heart attack at all stages. Many studies E.I. Chazov are recognized worldwide.
Recent advances in diagnosis and management of atrial fibrillation
Authors: Mironov N. Yu , Laiovich L. Yu , Mironova E. S , Sharf T. V , Aparina O. P , Mironova N. A , Stukalova O. V , Yuricheva Yu. A , Sokolov S. F , Novikov I. A , Maykov E. B , Pevzner A. V , Golitsyn S. P
Published: August 2019

Alterations of heart rhythm are a common clinical event. They can be caused by almost any kind of heart disorder. Atrial fibrillation (AF) is the most common type of abnormal heart rhythm. Prevalence of AF in the general population is 1-2%, and given that AF incidence rate continues to increase it can be predicted that the number of patients will be doubled within the next 50 years. This review provides the most recent diagnostic and treatment methods, including both unique domestic antiarrhythmic drugs and non - drug methods for AF treatment which were developed and implemented in clinical practice at NMRC of Cardiology of the Ministry of Health of the Russian Federation.
Antithrombotic therapy of coronary heart disease: time - tested essential principles
Authors: Panchenko E. P
Published: August 2019

History of antithrombotic therapy in cardiology has almost 70 years, and it is undoubtedly the importance of the achievements of Soviet scientists. The creation of a domestic thrombolytic fibrinolysin at MSU G. V. Andreenko, its first successful application in patients with myocardial infarction (MI), conducted by E. I. Chazov, and then by other domestic researchers, played a crucial role in proving the need for a quick restoration of the patency of infarct related artery. The world's first intracoronary thrombolysys, conducted by E. I. Chazov, together with the staff of the all-Union cardiological center, allowed to verify thrombosis as the cause of MI and demonstrate the effectiveness of thrombolytic therapy. One of the most important achievements of domestic researchers of the 60s of the last century was the understanding of the need not only to eliminate the thrombus by using of fibrinolysin, but also to prevent its recurrence, with administration of heparin with transition to VKA. This conclusion, in fact, is a statement of the need for long - term antithrombotic therapy in patients with сoronary artery disease (CAD). Over the past 70 years, antithrombotic therapy in CAD has undergone significant changes, this was facilitated by the undoubted progress in understanding the mechanisms of atherosclerosis and thrombosis development. Nevertheless, the basic principles of antithrombotic therapy, laid down by the national school in the 60s of the last century, have survived.