bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Cytotoxicity of Hyaluronic Acid/Chitosan/Bacterial Cellulose-Based Membrane
Authors: Dechojarassri Duangkamol , Okada Tomoki , Tamura Hiroshi , Furuike Tetsuya
Published: July 2023

Novel wound dressing materials are required to non-cytotoxic with a viable cell ratio of above 92%. Herein, the cytotoxicity of hyaluronic acid/chitosan/bacterial cellulose-based (BC(CS/HA)) membranes are evaluated and compared to that of alginate/chitosan/bacterial cellulose-based (BC(CS/Alg)) membranes was investigated. Multilayer membranes with up to ten CS/HA or CS/Alg layers were prepared using the layer-by-layer (LBL) method. Scanning electron microscopy showed that the diameters of the fibers in the BC(CS/Alg) and BC(CS/HA) membranes were larger than those in a BC membrane. The cytotoxicity was analyzed using BALB-3T3 clone A31 cells (mouse fibroblasts, 1 × 104 cells/well). The BC(CS/HA)5 and BC(CS/HA)10 membranes exhibited high biocompatibility, with the cell viabilities of 94% and 87% at 5 d, respectively, compared to just 82% for the BC(CS/Alg)5 and BC(CS/Alg)10 membranes with same numbers of layers. These results suggested that BC(CS/HA)5 is a promising material for wound dressings.
Effect of Self-Healing by Dicyclopentadiene Microcapsules on Tensile and Fatigue Properties of Epoxy Composites
Authors: Pandey Abhishek , Sharma Atul Kumar , Shukla Dharmendra Kumar , Pandey Kailash Narayan
Published: July 2023

Microcapsules of urea-formaldehyde (UF) containing dicyclopentadiene (DCPD) were synthesized by the in situ polymerization technique for self-healing of epoxy. The dispersion of microcapsules in the epoxy matrix was achieved using ultrasonication. Composites of epoxy, having 0.5, 1.0, 1.5, and 2.0 wt.% of microcapsules capable of self-healing, were prepared. The shape and size of the microcapsules were determined by field emission electron microscopy. Spherical capsules of DCPD, with an average diameter of 172 nm, were obtained. Investigation of tensile properties indicated a decrease in the tensile modulus with an increase in wt.% of microcapsules. There was a reduction of 22%, 27%, 39%, and 30% in the elastic modulus of composites for 0.5, 1.0, 1.5, and 2.0 wt.% of microcapsules, respectively. Tensile strength was found to increase with an increase in wt.% of microcapsules. The tensile strength of the composites increased by 33%, 20%, 8%, and 21% for 0.5, 1.0, 1.5, and 2.0 wt.% of microcapsules, respectively, in comparison with that of neat epoxy. The fatigue life of composites was investigated by conducting uniaxial tension–tension fatigue tests at constant stress amplitudes of 20, 25, 30, and 35 MPa, at a constant stress ratio (R = 0.1) and a frequency of 3 Hz. The fatigue life of composites increased with an increase in wt.% of microcapsules in comparison with that of neat epoxy. It was found that the fatigue life of the composites decreased with 1.5 and 2.0 wt.% of microcapsules in comparison with composites with 0.5 and 1.0 wt.% of microcapsules. The fracture surfaces of the tested samples were examined with the help of scanning electron microscopy (SEM) to understand the various mechanisms responsible for the change in modulus, strength, failure strain, and fatigue life of composites.
Pd-Based Nano-Catalysts Promote Biomass Lignin Conversion into Value-Added Chemicals
Authors: Zhao Ming , Zhao Liang , Zhao Xiao-Yan , Cao Jing-Pei , Maruyama Koh-ichi
Published: July 2023

Lignin, as a structurally complex biomaterial, offers a valuable resource for the production of aromatic chemicals; however, its selective conversion into desired products remains a challenging task. In this study, we prepared three types of Pd-based nano-catalysts and explored their application in the depolymerization of alkali lignin, under both H2-free (hydrogen transfer) conditions and H2 atmosphere conditions. The materials were well characterized with TEM, XRD, and XPS and others, and the electronic interactions among Pd, Ni, and P were analyzed. The results of lignin depolymerization experiments revealed that the ternary Pd-Ni-P catalyst exhibited remarkable performance and guaiacols could be produced under H2 atmosphere conditions in 14.2 wt.% yield with a selectivity of 89%. In contrast, Pd-Ni and Pd-P catalysts resulted in a dispersed product distribution. Considering the incorporation of P and the Pd-Ni synergistic effect in the Pd-Ni-P catalyst, a possible water-involved transformation route of lignin depolymerization was proposed. This work indicates that metal phosphides could be promising catalysts for the conversion of lignin and lignin-derived feedstocks into value-added chemicals.
Analysis of the Frictional Performance of AW-5251 Aluminium Alloy Sheets Using the Random Forest Machine Learning Algorithm and Multilayer Perceptron
Authors: Trzepieciński Tomasz , Najm Sherwan Mohammed , Ibrahim Omar Maghawry , Kowalik Marek
Published: July 2023

This paper is devoted to the determination of the coefficient of friction (COF) in the drawbead region in metal forming processes. As the test material, AW-5251 aluminium alloys sheets fabricated under various hardening conditions (AW-5251-O, AW-5251-H14, AW-5251-H16 and AW-5251H22) were used. The sheets were tested using a drawbead simulator with different countersample roughness and different orientations of the specimens in relation to the sheet rolling direction. A drawbead simulator was designed to model the friction conditions when the sheet metal passed through the drawbead in sheet metal forming. The experimental tests were carried out under conditions of dry friction and lubrication of the sheet metal surfaces with three lubricants: machine oil, hydraulic oil, and engine oil. Based on the results of the experimental tests, the value of the COF was determined. The Random Forest (RF) machine learning algorithm and artificial neural networks (ANNs) were used to identify the parameters affecting the COF. The R statistical package software version 4.1.0 was used for running the RF model and neural network. The relative importance of the inputs was analysed using 12 different activation functions in ANNs and nine different loss functions in the RF. Based on the experimental tests, it was concluded that the COF for samples cut along the sheet rolling direction was greater than for samples cut in the transverse direction. However, the COF’s most relevant input was oil viscosity (0.59), followed by the average counter sample roughness Ra (0.30) and the yield stress Rp0.2 and strength coefficient K (0.05 and 0.06, respectively). The hard sigmoid activation function had the poorest R2 (0.25) and nRMSE (0.30). The ideal run was found after training and testing the RF model (R2 = 0.90 ± 0.028). Ra values greater than 1.1 and Rp0.2 values between 105 and 190 resulted in a decreased COF. The COF values dropped to 9–35 for viscosity and 105–190 for Rp0.2, with a gap between 110 and 130 when the oil viscosity was added. The COF was low when the oil viscosity was 9–35, and the Ra was 0.95–1.25. The interaction between K and the other inputs, which produces a relatively limited range of reduced COF values, was the least relevant. The COF was reduced by setting the Rp0.2 between 105 and 190, the Ra between 0.95 and 1.25, and the oil viscosity between 9 and 35.
Hydrothermal Synthesis of a Cellular NiO Film on Carbon Paper as a Promising Way to Obtain a Hierarchically Organized Electrode for a Flexible Supercapacitor
Authors: Simonenko Tatiana L. , Simonenko Nikolay P. , Gorobtsov Philipp Yu. , Simonenko Elizaveta P. , Kuznetsov Nikolay T.
Published: July 2023

The formation of a cellular hierarchically organized NiO film on a carbon paper substrate under hydrothermal conditions using triethanolamine as a base has been studied. The thermal behavior of the carbon paper substrate with the applied semi-product shell was studied using synchronous thermal analysis (TGA/DSC) and it was demonstrated that such modification of the material surface leads to a noticeable increase in its thermal stability. Using scanning electron microscopy (SEM), it was shown that the NiO film grown on the carbon fiber surface is characterized by a complex cellular morphology, organized by partially layered individual nanosheets of about 4–5 nm thickness and lateral dimensions up to 1–2 μm, some edges and folds of which are located vertically relative to the carbon fiber surface. The surface of the obtained material was also examined using atomic force microscopy (AFM), and the electronic work function of the oxide shell surface was evaluated using the Kelvin probe force microscopy (KPFM) method. The electrochemical parameters of the obtained flexible NiO/CP electrode were analyzed: the dependence of the specific capacitance on the current density was determined and the stability of the material during cycling was studied, which showed that the proposed approach is promising for manufacturing hierarchically organized electrodes for flexible supercapacitors.
Moments of the Negative Multinomial Distribution
Authors: Ouimet Frédéric
Published: July 2023

The negative multinomial distribution appears in many areas of applications such as polarimetric image processing and the analysis of longitudinal count data. In previous studies, general formulas for the falling factorial moments and cumulants of the negative multinomial distribution were obtained. However, despite the availability of the moment generating function, no comprehensive formulas for the moments have been calculated thus far. This paper addresses this gap by presenting general formulas for both central and non-central moments of the negative multinomial distribution. These formulas are expressed in terms of binomial coefficients and Stirling numbers of the second kind. Utilizing these formulas, we provide explicit expressions for all central moments up to the fourth order and all non-central moments up to the eighth order.
Modulatory Effect of Rosmarinic Acid on H2O2-Induced Adaptive Glycolytic Response in Dermal Fibroblasts
Authors: Charoensin Suphachai , Dansakda Suwatsak
Published: July 2023

Oxidative stress induces the adaptive response and alteration of energy metabolism across human cell types. Dermal fibroblasts shift their energy system to overload anaerobic glycolysis when exposed to sub-lethal hydrogen peroxide (H2O2). However, oxidative stress levels in the cells can be depleted by antioxidants, and such cellular changes can therefore be modulated. The present study aimed to investigate the modulatory effect of rosmarinic acid (a polyphenol antioxidant) against H2O2-induced reactive oxygen species (ROS) and the glycolytic adaptive response in fibroblasts. The results showed that H2O2 caused a significant ROS increase in the cells, and pre-treatment with rosmarinic acid (5–50 µM) decreased ROS significantly in the presence of glutathione. Rosmarinic acid modulated the adaptive response in H2O2-treated cells by decreasing glucose consumption and lactate production. The rosmarinic acid also recovered intracellular ATP and decreased NADPH production via the pentose phosphate pathway. Several glycolytic enzymes, including hexokinase-2 (HK-2), phosphofructokinase-2 (PFK-2), and lactate dehydrogenase A (LDHA), were downregulated in cells treated with rosmarinic acid. Furthermore, the key antioxidant enzymes: glutathione-disulfide reductase (GSR), glutathione peroxidase-1 (GPx-1), and peroxiredoxin-1 (Prx-1) and redox protein thioredoxin-1 (Trx-1) were upregulated in treated cells compared to control cells. To sum up, the rosmarinic acid could be used as an antioxidant against H2O2-induced adaptive responses in fibroblasts by modulating glucose metabolism, glycolytic genes, and GSH production. The present work indicates that rosmarinic acid holds promise in cell-based research applications for combating ROS and enhancing dermal fibroblast health.
Tunable Contact Types and Interfacial Electronic Properties in TaS2/MoS2 and TaS2/WSe2 Heterostructures
Authors: Zhu Xiangjiu , Jiang Hongxing , Zhang Yukai , Wang Dandan , Fan Lin , Chen Yanli , Qu Xin , Yang Lihua , Liu Yang
Published: July 2023

Following the successful experimental synthesis of single-layer metallic 1T-TaS2 and semiconducting 2H-MoS2, 2H-WSe2, we perform a first-principles study to investigate the electronic and interfacial features of metal/semiconductor 1T-TaS2/2H-MoS2 and 1T-TaS2/2H-WSe2 van der Waals heterostructures (vdWHs) contact. We show that 1T-TaS2/2H-MoS2 and 1T-TaS2/2H-WSe2 form n-type Schottky contact (n-ShC type) and p-type Schottky contact (p-ShC type) with ultralow Schottky barrier height (SBH), respectively. This indicates that 1T-TaS2 can be considered as an effective metal contact with high charge injection efficiency for 2H-MoS2, 2H-WSe2 semiconductors. In addition, the electronic structure and interfacial properties of 1T-TaS2/2H-MoS2 and 1T-TaS2/2H-WSe2 van der Waals heterostructures can be transformed from n-type to p-type Schottky contact through the effect of layer spacing and the electric field. At the same time, the transition from Schottky contact to Ohmic contact can also occur by relying on the electric field and different interlayer spacing. Our results may provide a new approach for photoelectric application design based on metal/semiconductor 1T-TaS2/2H-MoS2 and 1T-TaS2/2H-WSe2 van der Waals heterostructures.
Quercetin Antagonizes the Sedative Effects of Linalool, Possibly through the GABAergic Interaction Pathway
Authors: Bappi Mehedi Hasan , Prottay Abdullah Al Shamsh , Kamli Hossam , Sonia Fatema Akter , Mia Md. Nayem , Akbor Md. Showkoth , Hossen Md. Munnaf , Awadallah Samir , Mubarak Mohammad S. , Islam Muhammad Torequl
Published: July 2023

Sedatives promote calmness or sleepiness during surgery or severely stressful events. In addition, depression is a mental health issue that negatively affects emotional well-being. A group of drugs called anti-depressants is used to treat major depressive illnesses. The aim of the present work was to evaluate the effects of quercetin (QUR) and linalool (LIN) on thiopental sodium (TS)-induced sleeping mice and to investigate the combined effects of these compounds using a conventional co-treatment strategy and in silico studies. For this, the TS-induced sleeping mice were monitored to compare the occurrence, latency, and duration of the sleep-in response to QUR (10, 25, 50 mg/kg), LIN (10, 25, 50 mg/kg), and diazepam (DZP, 3 mg/kg, i.p.). Moreover, an in silico investigation was undertaken to assess this study’s putative modulatory sedation mechanism. For this, we observed the ability of test and standard medications to interact with various gamma-aminobutyric acid A receptor (GABAA) subunits. Results revealed that QUR and LIN cause dose-dependent antidepressant-like and sedative-like effects in animals, respectively. In addition, QUR-50 mg/kg and LIN-50 mg/kg and/or DZP-3 mg/kg combined were associated with an increased latency period and reduced sleeping times in animals. Results of the in silico studies demonstrated that QUR has better binding interaction with GABAA α3, β1, and γ2 subunits when compared with DZP, whereas LIN showed moderate affinity with the GABAA receptor. Taken together, the sleep duration of LIN and DZP is opposed by QUR in TS-induced sleeping mice, suggesting that QUR may be responsible for providing sedation-antagonizing effects through the GABAergic interaction pathway.
Unraveling the Critical Mechanisms and Functions of Neuroglia in Spinal Cord Injuries
Authors: Zeng Chih-Wei
Published: July 2023

In the dynamic landscape of neuroscience and regenerative medicine, the pivotal role of neuroglia, or glial cells, is increasingly being recognized [...]
The Impact of Psychological Factors on Return to Sports after Anterior Cruciate Ligament Reconstruction: A Systematic Review
Authors: Longo Umile Giuseppe , De Salvatore Sergio , D’Orrico Federica , Bella Matilda , Corradini Alessandra , Rizzello Giacomo , De Marinis Maria Grazia , Denaro Vincenzo
Published: July 2023

The rehabilitation of those who have undergone anterior cruciate ligament reconstruction (ACL-R) is a complex process that involves many factors. Physical ability recovery is not the only factor in the return to sport; psychosocial factors such as anxiety, pain response, self-esteem, locus of control, and fear of re-injury also play an important role. A systematic search was conducted on the PubMed, Medline, Cochrane, CINAHL and Embase databases using the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). No randomized controlled trials (RCTs) were identified. The Methodological Index for Non-Randomized Studies (MINOR) was used to assess the quality of the identified non-RCT studies. A total of 308 studies were identified, of which 32 met the eligibility criteria. The results of these studies were obtained using the KOOS (ADL, Sport, QoL), ACL, TSK-11, K-SES, questionnaires/interviews, and other scales as instrumental approaches. This systematic review and meta-analysis revealed that psychological factors have a significant influence on the post-anterior cruciate ligament reconstruction outcomes of athletes. Fear of re-injury and pain were the primary factors that limited return to sport, whereas self-efficacy, psychological will, and age were associated with better functional outcomes and were essential for male and young patients. Clinicians should focus on both physical and psychological components to optimize rehabilitation.
Gaussian-Filtered High-Frequency-Feature Trained Optimized BiLSTM Network for Spoofed-Speech Classification
Authors: Mewada Hiren , Al-Asad Jawad F. , Almalki Faris A. , Khan Adil H. , Almujally Nouf Abdullah , El-Nakla Samir , Naith Qamar
Published: July 2023

Voice-controlled devices are in demand due to their hands-free controls. However, using voice-controlled devices in sensitive scenarios like smartphone applications and financial transactions requires protection against fraudulent attacks referred to as “speech spoofing”. The algorithms used in spoof attacks are practically unknown; hence, further analysis and development of spoof-detection models for improving spoof classification are required. A study of the spoofed-speech spectrum suggests that high-frequency features are able to discriminate genuine speech from spoofed speech well. Typically, linear or triangular filter banks are used to obtain high-frequency features. However, a Gaussian filter can extract more global information than a triangular filter. In addition, MFCC features are preferable among other speech features because of their lower covariance. Therefore, in this study, the use of a Gaussian filter is proposed for the extraction of inverted MFCC (iMFCC) features, providing high-frequency features. Complementary features are integrated with iMFCC to strengthen the features that aid in the discrimination of spoof speech. Deep learning has been proven to be efficient in classification applications, but the selection of its hyper-parameters and architecture is crucial and directly affects performance. Therefore, a Bayesian algorithm is used to optimize the BiLSTM network. Thus, in this study, we build a high-frequency-based optimized BiLSTM network to classify the spoofed-speech signal, and we present an extensive investigation using the ASVSpoof 2017 dataset. The optimized BiLSTM model is successfully trained with the least epoch and achieved a 99.58% validation accuracy. The proposed algorithm achieved a 6.58% EER on the evaluation dataset, with a relative improvement of 78% on a baseline spoof-identification system.
Automated Laser-Fiber Coupling Module for Optical-Resolution Photoacoustic Microscopy
Authors: Han Seongyi , Kye Hyunjun , Kim Chang-Seok , Kim Tae-Kyoung , Yoo Jinwoo , Kim Jeesu
Published: July 2023

Photoacoustic imaging has emerged as a promising biomedical imaging technique that enables visualization of the optical absorption characteristics of biological tissues in vivo. Among the different photoacoustic imaging system configurations, optical-resolution photoacoustic microscopy stands out by providing high spatial resolution using a tightly focused laser beam, which is typically transmitted through optical fibers. Achieving high-quality images depends significantly on optical fluence, which is directly proportional to the signal-to-noise ratio. Hence, optimizing the laser-fiber coupling is critical. Conventional coupling systems require manual adjustment of the optical path to direct the laser beam into the fiber, which is a repetitive and time-consuming process. In this study, we propose an automated laser-fiber coupling module that optimizes laser delivery and minimizes the need for manual intervention. By incorporating a motor-mounted mirror holder and proportional derivative control, we successfully achieved efficient and robust laser delivery. The performance of the proposed system was evaluated using a leaf-skeleton phantom in vitro and a human finger in vivo, resulting in high-quality photoacoustic images. This innovation has the potential to significantly enhance the quality and efficiency of optical-resolution photoacoustic microscopy.
Rolling Bearing Fault Diagnosis Based on Support Vector Machine Optimized by Improved Grey Wolf Algorithm
Authors: Shen Weijie , Xiao Maohua , Wang Zhenyu , Song Xinmin
Published: July 2023

This study targets the low accuracy and efficiency of the support vector machine (SVM) algorithm in rolling bearing fault diagnosis. An improved grey wolf optimizer (IGWO) algorithm was proposed based on deep learning and a swarm intelligence optimization algorithm to optimize the structural parameters of SVM and improve the rolling bearing fault diagnosis. A nonlinear contraction factor update strategy was also proposed. The variable coefficient changes with the shrinkage factor α. Thus, the search ability was balanced at different early and late stages by controlling the dynamic changes of the variable coefficient. In the early stages of optimization, its speed is low to avoid falling into local optimization. In the later stages of optimization, the speed is higher, and finding the optimal solution is easier, balancing the two different global and local optimization capabilities to complete efficient convergence. The dynamic weight update strategy was adopted to perform position updates based on adaptive dynamic weights. First, the dataset of Case Western Reserve University was used for simulation, and the results showed that the diagnosis accuracy of IGWO-SVM was 98.75%. Then, the IGWO-SVM model was trained and tested using data obtained from the full-life-cycle test platform of mechanical transmission bearings independently researched and developed by Nanjing Agricultural University. The fault diagnosis accuracy and convergence value of the adaptation curve were compared with those of PSO-SVM (particle swarm optimization) and GWO-SVM diagnosis models. Results showed that the IGWO-SVM model had the highest rolling bearing fault diagnosis accuracy and the best diagnosis convergence.
Photonics Scanning Pentaprism System for the Integrated Inspection of Large-Aperture Telescopes
Authors: An Qichang , Zhang Hanfu , Wang Kun , Liu Xinyue , Li Hongwen
Published: July 2023

To improve their spatial resolution and detection capabilities, future ground-based optical telescopes will have a size of 30 m, and the aperture of space telescopes will be increased to 10 m. Such large optical systems necessitate the development of large integrated testing equipment. In this study, spectrum and system alignment measurements and wavefront quality checking were performed using the sub-aperture detection method and a fiber-connected Photonics Scanning Pentaprism (PSP). First, the system was aligned using an optical truss, ensuring that the optical axis was properly positioned. Second, using a sub-aperture light beam though the entrance pupil, light spots were formed on the focal plane and transmitted to the spectrometer via fibers to obtain the corresponding spectral components. Then, by taking measurements at different system positions, a full-aperture spectrum response could be reached. Lastly, by photon-integrated interference on the focal plane, intensity interference fringes could be projected at the entrance pupil of the system. And the wavefront quality of the system could be verified by observing the fringe deformation. The measurement accuracy of the optical axis of the system is better than 2 mrad. The spectral measurement accuracy was better than 5%, and the wavefront measurement accuracy surpassed 0.1 wavelengths (1 wavelength = 633 nm). This study effectively enhanced the detection and in situ calibration capabilities of large telescope systems, ensuring that the performance requirements can be met in the design of future telescopes.
Pulmonary tuberculosis in patients with mental disorders in combination with alcoholism
Authors:   Samara Regional Clinical Psychiatric Hospital, Ovchinnikova O. V. , Poluektova E. A. ,   Samara Regional Clinical Psychiatric Hospital, Hovhannisyan V. A. ,   Samara Regional Clinical Psychiatric Hospital
Published: July 2023

The article presents an assessment of the characteristics of the clinical and psychological state of patients with comorbid pathology (pulmonary tuberculosis and mental disorder) in combination with alcoholism. The purpose of assessing the characteristics of the clinical and psychological state of this category of persons is to create a medical and social portrait of the latter. Results. The study showed that a fairly high percentage of patients with comorbid pathology (pulmonary tuberculosis and mental disorder) are dependent on psychoactive substances. For the studied category of persons, characteristic psychological features and cognitive impairments were revealed. Conclusion. Taking into account the results of the study, it is necessary, in addition to the main anti-tuberculosis treatment, to such patients to carry out therapeutic measures aimed at improving cognitive functions and involve them in rehabilitation psychological and correctional programs. In terms of providing medical care, pay special attention to the organization and implementation of comprehensive treatment for patients with alcohol dependence and comorbid pulmonary tuberculosis, to implement it jointly: by phthisiatricians, psychiatrists, psychologists and narcologists.
CRITERIA FOR ASSESSING THE CATEGORY OF TECHNICAL CONDITION OF REINFORCED CONCRETE COLUMNS, CROSSBARS, BEAMS AND TRUSSES
Authors:   Russian University of Transport, FEDOROV V.S. , TREKIN N.N. ,   National Research Moscow State University of Civil Engineering, KODYSH E.N. ,   JSC TSNIIPromzdaniy, TEREKHOV I.A. ,   Russian University of Transport
Published: July 2023

The article considers the process of formation of evaluation criteria in the course of operation of the category of technical condition of reinforced concrete columns, crossbars, beams and trusses. Criteria for limited serviceability and emergency conditions were determined using calculations using the method of limiting forces, taking into account the bearing capacity reserves laid down in the design. As an example, one characteristic design defect for each type of structure is considered. The establishment of criteria for defects that were not considered in the calculations was carried out by analyzing and studying the characteristic defects of building structures of buildings and structures based on data from previous studies, as well as based on the results of consideration of other regulatory and technical documents. The criteria given in the final table were proposed for inclusion in the second edition of the revision of GOST 31937–2011 «Buildings and constructions. Rules of inspection and monitoring of the technical condition».
SOCIO-DIAGNOSTIC RESEARCH OF THE PROBLEM OF THE FORMATION OF HISTORICAL AND CULTURAL LANDSCAPES (ON THE EXAMPLE OF THE CITY OF SUZDAL)
Authors:   National Research University Moscow State University of Civil Engineering, BAKAEVA N.V. , ROMANOV N.A. ,   National Research University Moscow State University of Civil Engineering
Published: July 2023

Today, in the field of urban planning, the problem of preserving the recreational potential of natural territories, in particular the territories of historical and cultural landscapes, and the creation of urban public spaces in symbiosis with the natural environment in these territories is becoming increasingly important. In the theory and practice of urban planning, there is no scientifically based approach to the restoration and ecological reconstruction of the territory of historical and cultural landscapes from the standpoint of their sustainable development, as a result of which the territory of protected meadows in Suzdal has been in an environmentally unfavorable state for a long time with signs of degradation of landscape components. The purpose of the planned ecological reconstruction of urban landscapes in the city of Suzdal is to ensure a dynamic balance between the natural and urbanized environment. One of the ways to achieve such a balance, as well as to preserve the environment and improve the well-being of the local population, can be the development of eco-tourism as a tool to solve the problem of congestion in the central part of the historical settlement due to the seasonal influx of tourists. In order to reduce the anthropogenic load on the historical environment of the city, improve the welfare of the population, get acquainted with the local culture and the natural environment, it is important to separate tourist flows in different directions in green spaces along the river along organized ecological trails. During the socio-diagnostic research of the territory of historical and cultural landscapes, the dynamics of the transformation of the territory of landscapes were established and an assessment of the ecological state of the reserched territory was carried out, revealing, at the same time, the possibility of their restoration. The conducted sociological survey determined the attitude of residents and tourists of the city of Suzdal to this problem as an interested social group of the population.
MULTI-COMFORT ENVIRONMENT IN THE ARCHITECTURE OF PRE-RESTRUCTED BUILDINGS
Authors:   Southwestern State University, VOLICHENKO O.V. , LITYAGINA A.V. ,   Southwestern State University
Published: July 2023

The problems of prefabrication, cost-effectiveness, strength and energy efficiency of buildings of residential and civil architecture are becoming especially relevant at the present time, due to the need to quickly restore the destroyed cities and villages in the newly annexed territories. For the purpose of an experimental proposal for a residential building project based on the concept of multi-comfort, an analysis of the development of industrial construction methods was carried out. A review of the evolutionary development of industrial housing construction made it possible to identify its advantages (speed of construction, low cost, simplicity of design solutions, etc.), disadvantages (low quality and comfort level, standard stamps, etc.) and ways to eliminate them (increased comfort, energy efficiency, development new constructive solutions, artistic expressiveness, planning variability, etc.). The authors propose the development of a project for a prefabricated residential building based on innovative frame-type panels manufactured in the factory. These structures are quickly mounted on the construction site, they are characterized by increased rigidity, survivability and material consumption. This constructive system provides an opportunity to create flexible architectural and planning solutions with a variety of plastic shapes of the building. Energy efficiency and multi-comfort environment of a residential building is achieved by the orientation of the building on the designed site, the use of insulating materials and glazing (reduction of heat loss and noise protection). The shape of the building also ensures the thermal comfort of the yard space. Wind currents are broken by protruding and sinking architectural elements, creating complex and meaningful compositional connections. The use of new industrial structures allows, using the principles of energy-efficient design, to increase the level of comfort and efficiency of a residential building, solve the problems of viability and quick erection of buildings, and create an expressive architectural and artistic appearance of the residential environment.
Prevención de CLABSI por el uso de tapón desinfectante 3M Curos®: metanálisis y evaluación económica
Authors: de la Rosa Zamboni Daniela , Florián Rodríguez Diana , Valls Pallejà Marc , Castillo Sánchez Victoria , Gay Molina Juan Gabriel
Published: July 2023

Background. Healthcare-associated infections are a relevant health-public issue because of their economic and social impact; thus, they represent a challenge for the health institutions and the personnel in charge of fighting the infections. Particularly, central venous catheter-associated infections require a long-period administration of antibiotics, which increases the catheter blockade. That may derive in replacing the catheter, more extended hospital stays, and a higher sepsis risk. Objective. To analyze the efficacy of the disinfectant cap (3M Curos®), compared to the traditional disinfection method of the needle-free connectors, catheters or disinfectant ports. Material and Methods. A systematic review, meta-analysis, and cost-effectiveness study were performed to determine the effectiveness of the disinfectant cap in order to define the efficiency compared to the traditional disinfection method. Univariate, multivariate, and probabilistic sensitivity analyses were performed to reduce uncertainty. Results. The disinfectant cap had an infection ratio of 1.54 infections per 1,000 catheters / day vs. traditional desinfection methods, which had a ratio of 4.84 infections per 1,000 catheters / day. Those results led to find a cost difference of $21,819.39 USD for 3M Curos® and $67,165.26 USD for traditional methods. Conclusions. The disinfectant cap proves to be a more efficient alternative for pediatric health in Mexico.
Medicamentos herbolarios utilizados en el manejo de la osteoartrosis: revisión sistemática
Authors: Castañeda-Hernández Gilberto , Salmon-Demongin Alfredo , Domínguez Gonzalo , Tolentino-Hernández Suset Jannette
Published: July 2023

Introduction. Osteoarthrosis (OA) is the most common rheumatic disease and often results in disability. Its treatment must be comprehensive and consider several aspects. However, the chronic use of anti-inflammatory drugs is associated with severe gastrointestinal, cardiovascular, hematological, and renal adverse reactions. Medicinal plants have been used for centuries in the management of this disease. Objective. This study aimed to carry out a systematic review of the published evidence of 13 plants whose use in OA has been reported. Material and Methods. The search strategy included the following criteria: documents written in English and Spanish, full texts, studies in humans, clinical guidelines, systematic reviews, meta-analysis, randomized clinical studies, observational /epidemiological/ economic studies, reviews, consensus. Particular emphasis was placed on the pharmacological mechanism of action that could justify their use and support the clinical efficacy. The evidence obtained was selected through work questions and level of evidence. Results. Seven hundred and thirty-four articles were found; 346 out of them were chosen to be analyzed. Pro-inflammatory cytokines inhibition, reduction in TNF-α and NF-κB signaling, decrease in osteoclastogenesis, increase in the osteoclasts differentiation, decrease in cyclooxygenase 2 activity, and prostaglandins synthesis are among the mechanisms of action of the studied plants. Conclusions. The several plants reviewed have mechanisms of action that support their use in treating OA and have varying degrees of demonstrated efficacy.
Can ESG Policy Become the Sustainability Catalyst of Company Performance During Covid-19 Pandemic?
Authors: Hendriyeni Nora Sri , Pinasthika Benediktus Tandya , Akbar Ilham Muhammad
Published: July 2023

This study is conducted to discover the influence of environmental, social, and governance (ESG) policy on company performance during the Covid-19 pandemic. Both the company principal and agent are expected to consider the impact of developing a policy during the pandemic, especially concerning ESG policy. The ESG disclosure study aims to verify whether the policy, which is proxied with standard Global Reporting Initiative (GRI) disclosure in the sustainability report, influences company performance, which is proxied with Tobinâ€™s Q ratio as a measure to discover the market response. It is founded on the urgency that the pandemic alters investorsâ€™ views about the company. This research failed to verify H1 or the influence of ESG disclosure on company performance. On the other hand, H2 and H3, including control variables, significantly influence company performance, as well as the Independence of the board of directors (BoD) and board of commissioners (BoC), which also have a significant but negative influence. This study has practical implications in which disclosure of ESG policy does not significantly influence company performance due to the management mindset, which still focuses on short-term conditions. It is thus necessary to develop a long-term strategic plan while taking sustainability into account.
A Study on Role of Health Care Management Streams
Authors: Perumal S , Dhanasekaran S
Published: July 2023

Health care is the maintenance or improvement of health care via the prevention, diagnosis, treatment, amelioration, or cure of disease, illness, injury, and other physical and mental impairments in people. Health care is delivered by health care professionals and allied health care fields. Medicine, dentistry, pharmacy, midwifery, nursing, optometry, audiology, psychology, occupational therapy, physical therapy, athletic training, and other health professions are all part of health care. It includes work done in providing primary care, secondary care, and tertiary care, as well as in public healthcare. Access to health care may vary across countries, communities, and individuals, influenced by social and economic conditions as well as health care policies. Providing health care services means “the timely use of personal health care services to achieve the best possible health care outcomes. A limitation to health care services affects negatively the use of medical services, the efficacy of treatments, and overall outcome (well-being, mortality rates). An efficient health care system can contribute to a significant part of a country’s economy, development, and industrialization. Health care is conventionally regarded as an important determinant in promoting the general physical and mental health care and well-being of people around the world, An example of this was the worldwide eradication of smallpox in 1980, declared by the WHO as the first disease in human history to be eliminated by deliberate health care interventions.
Recrimination of Shikandi in Devdutt Pattanaik’s Shikhandi and Other Tales They Don't Tell You
Authors: Balaji K , Narmadhaa M
Published: July 2023

Indian Writing has turned out to be a new form of Indian culture and voice in which idea converses regularly. Indian writers-poets, novelists, essayists, and dramatists have been making momentous and considerable contribution to world Literature since pre-Independence era, the past few years have witnessed a gigantic prospecting and thinking of Indian English writing in the global market. Sri Aurobindo stands like a huge oak spreading its branches over these two centuries. He is the first poet in Indian writing English who was given the re-interpretation of Myths. Tagore is the most eminent writer he translated many of his poems and plays into English who wrote probably the largest number of lyrics even attempted by any poet. The word “myth” is divided from the Greek word mythos, which simply means “story”. Mythology can refer either to the study of myths or to a body or a collection of myths. A myth by definition is “true” in that it. The same myth appears in various versions, varies with diverse traditions, modified by various Hindu traditions, regional beliefs and philosophical schools, over time. Devdutt Pattanaik is an Indian Mythologist who distinguishes between mythological fiction is very popular as it is fantasy rooted in familiar tradition tales. His books include Myth =Mithya: A Handbook of Hindu Mythology, Jaya: An illustrated Retelling of Mahabharata; Business Sutra: An Indian Approach to Management; Shikandi: And other Tales they Don’t Tell you; and so on.
Insectos: Uso como materia prima en la industria alimentaria y no alimentaria
Authors: Pico-Poma Josselyn Paulina , Sarabia-Guevara Diego Abelardo , Landívar-Valverde Marcos David , Cevallos-Lucas Erika Gabriela
Published: July 2023

El objetivo general de la investigación consistió en analizar los insectos y el uso como materia prima en la industria alimentaria y no alimentaria. El tipo de investigación del presente trabajo correspondió a una investigación descriptiva simple, la cual permitió describir y analizar toda la información referente al uso de los insectos y sus productos como materia prima en la industria. Los resultados evidenciaron que los productos de insectos comercialmente valiosos como: Miel, jalea real, propóleos, polen, seda, carmín, entre otros. están disponibles debido a la importancia de estos recursos en la industria. se puede concluir que, entre los tipos de insectos utilizados rutinariamente en la industria alimentaria y no alimentaria, destacan los órdenes Coleoptera, Lepidoptera, Hymenoptera, Orthoptera, Hemiptera, Odonata y Diptera. El surtido de insectos y sus productos representa la fuente de materias primas para el procesamiento de productos derivados en la industria alimenticia y no alimenticia.
El diseño universal del aprendizaje y su importancia en la educación pública ecuatoriana
Authors: Maldonado Alarcón Sandra , Esteves-Fajardo Zila Isabel
Published: July 2023

El objetivo general de la presente investigación fue describir el diseño universal del aprendizaje y su importancia en la educación pública ecuatoriana. Con apoyo metodológico de tipo documental descriptivo y un diseño bibliográfico, la investigación se construyó desde una perspectiva cuantitativa, lo que posibilitó el recorrido por el tema investigado.  Con la ayuda del método de análisis de contenido, que se utilizó a lo largo de toda la investigación, fue posible estudiar los datos recopilados. Se empleó como instrumento de investigación, la ficha o guía de análisis documental, lo que contribuyó a extraer las ideas y contrastarlas, de artículos arbitrados y tesis, entre otros. Se concluye que, la promoción de nuevas estrategias en el proceso de enseñanza aprendizaje en la educación pública, constituye un reto de gestión pública en materia educativa en la cual deben participar los padres de familia, escuela, estudiantes y comunidad, para mejorar las políticas de inclusión.
Fortalecimiento de las estrategias didácticas para activar el desarrollo de los procesos de pensamiento
Authors: Yumi-Cutiupala Martha Cecilia , Esteves-Fajardo Zila Isabel
Published: July 2023

El objetivo general de la presente investigación fue describir el fortalecimiento de las estrategias didácticas para activar el desarrollo de los procesos de pensamiento. El desarrollo de la investigación, se realizó desde la perspectiva cuantitativa, de tipo descriptiva y se complementó por un diseño documental-bibliográfico. La información fue extraída de los diferentes artículos arbitrados, trabajo de grado, entre otros. Se concluye que, el crecimiento de los procesos de pensamiento es ventajoso porque le permite a la persona ampliar diversas habilidades que utiliza en su día a día, capacitándolo para actuar, pensar y crear, aumentando capacidades y habilidades desde una edad temprana, desde la didáctica y los planes de formación incrementando el pensamiento lógico, crítico, creativo y matemático.
Formación de valores en la edad inicial
Authors: Apiña-Pérez María Fernanda , Cuadrado-Vaca Jorge Gustavo
Published: July 2023

El objetivo general de la investigación fue describir la formación de valores en la edad inicial. Los investigadores se plantearon el método desde el paradigma positivista y la perspectiva cuantitativa, se apoyó en una técnica descriptiva con diseño documental-bibliográfico no experimental. Se desarrolló de acuerdo con un diseño de investigación documental. Se procedió a la revisión documental de revistas científicas, y tesis, vinculados al tema investigativo, lo que constituyó la población de estudio. Se puede concluir, que es de gran importancia la construcción de los valores y antivalores como parte del fortalecimiento de la personalidad de cada individuo, en especial de los niños donde su proceso de formación inicia en el hogar y en la escuela se va fortaleciendo mediante el intercambio con sus pares. Es necesario fomentar los valores en el aula, de ellos dependerá la capacidad que tienen los niños a relacionarse de una manera armónica.
La metodología TiNi y su entramado legal en el contexto ecuatoriano
Authors: Villanueva-Fuentes Anita María , Quito-Esteves. Valeria Paulina
Published: July 2023

La sociedad actual demanda de buenas prácticas educativas que se desplieguen cotidianamente y se traduzcan en iniciativas innovadoras que bien concienticen y empoderen al estudiante como verdaderos ciudadanos protagonistas de los cambios socio-ambientales requeridos. Considerando esto, se presenta el siguiente artículo a cuyo objetivo estuvo enmarcado en identificar instrumentos legales directos que soportan la aplicación la Metodología TiNi en el contexto ecuatoriano. Metodológicamente, responde a una investigación de tipo documental descriptiva, desarrollada mediante un diseño bibliográfico. Finalmente, se puede enunciar que la Metodología “Tierra de niñas, niños y jóvenes para el Buen Vivir – TiNi”, lo soporta todo un entramado de instrumentos jurídicos y legales, de índole nacional e internacional, que le dan asidero como programa estratégico para la Educación Ambiental y el desarrollo integral de los estudiantes en Ecuador.
Mediación escolar y práctica restaurativa para la conciliación y prevención de los conflictos de aula
Authors: Rocha-Tayupanta Geoconda Elizabeth , Quito-Esteves. Valeria Paulina
Published: July 2023

El manejo de conflictos que se viven en la cotidianidad del aula demanda estrategias idóneas para su resolución exitosa, pues las comunidades escolares tienen el derecho a convivir en un buen clima escolar. A partir de este planteamiento se desarrolló el presente artículo cuyo objetivo fue describir la mediación escolar y las prácticas restaurativas como estrategias para la conciliación y prevención de conflictos en el aula. Metodológicamente, el estudio refiere a una investigación de tipo documental descriptiva, la cual se desarrolló mediante un diseño bibliográfico. A manera de conclusión se puede enunciar que la mediación escolar implicada con las practicas restaurativas, se constituyen en una real posibilidad para generar espacios de gestión positiva y pacífica de los conflictos en ámbitos educativos.
Importancia de los pictogramas para el inicio de la prelectura
Authors: Puetate Manitio Gloria Irene , Esteves-Fajardo Zila Isabel
Published: July 2023

La lectura, aparte de estimular múltiples habilidades y procesos cognitivos, es la base de la comunicación humana. Es por ello que es fundamental, desde las primeras etapas de vida escolar, obligatoria o no, el desarrollo de procesos enmarcados en la prelectura con estrategias pertinentes para ello. Desde este contexto, se presenta el siguiente articulo cuyo propósito fue describir la importancia de los pictogramas para el inicio de la prelectura. En cuanto a la metodología, esta se definió como un estudio de tipo documental, desarrollado a nivel descriptivo y con sustento en un diseño bibliográfico. Finalmente se puede expresar que el pictograma, al ser una simbología gráfica capaz de transmitir un mensaje, se constituye en una potente estrategia para el desarrollo del niño como lector en sus primeras etapas escolares. Pues, los pictogramas dotan al lenguaje verbal de estructura y regulación, coadyuvando al aprendizaje de competencias de prelectura.