bluuebunny/crossref_metadata_2025 huggingface dataset:
Changing antibiotic prescribing practices in outpatient primary care settings in China: Study protocol for a health information system-based cluster-randomised crossover controlled trial
Authors: Chang Yue , Yao Yuanfan , Cui Zhezhe , Yang Guanghong , Li Duan , Wang Lei , Tang Lei
Published: January 2022

Background

The overuse and abuse of antibiotics is a major risk factor for antibiotic resistance in primary care settings of China. In this study, the effectiveness of an automatically-presented, privacy-protecting, computer information technology (IT)-based antibiotic feedback intervention will be evaluated to determine whether it can reduce antibiotic prescribing rates and unreasonable prescribing behaviours.

Methods

We will pilot and develop a cluster-randomised, open controlled, crossover, superiority trial. A total of 320 outpatient physicians in 6 counties of Guizhou province who met the standard will be randomly divided into intervention group and control group with a primary care hospital being the unit of cluster allocation. In the intervention group, the three components of the feedback intervention included: 1. Artificial intelligence (AI)-based real-time warnings of improper antibiotic use; 2. Pop-up windows of antibiotic prescription rate ranking; 3. Distribution of educational manuals. In the control group, no form of intervention will be provided. The trial will last for 6 months and will be divided into two phases of three months each. The two groups will crossover after 3 months. The primary outcome is the 10-day antibiotic prescription rate of physicians. The secondary outcome is the rational use of antibiotic prescriptions. The acceptability and feasibility of this feedback intervention study will be evaluated using both qualitative and quantitative assessment methods.

Discussion

This study will overcome limitations of our previous study, which only focused on reducing antibiotic prescription rates. AI techniques and an educational intervention will be used in this study to effectively reduce antibiotic prescription rates and antibiotic irregularities. This study will also provide new ideas and approaches for further research in this area.

Trial registration

ISRCTN, ID: ISRCTN13817256. Registered on 11 January 2020.
A multi-center, international, randomized, 2-year, parallel-group study to assess the superiority of IVUS-guided PCI versus qualitative angio-guided PCI in unprotected left main coronary artery (ULMCA) disease: Study protocol for OPTIMAL trial
Authors: De Maria Giovanni Luigi , Testa Luca , de la Torre Hernandez Jose M. , Terentes-Printzios Dimitrios , Emfietzoglou Maria , Scarsini Roberto , Bedogni Francesco , Spitzer Ernest , Banning Adrian
Published: January 2022

Background

Percutaneous coronary intervention (PCI) is used increasingly for revascularization of unprotected left main coronary artery (LMCA) disease. Observational studies and subgroup analyses from clinical trials, have suggested a possible benefit from the use of intravascular ultrasound (IVUS) guidance when performing unprotected LMCA PCI. However, the value of imaging with IVUS has never been proven in an appropriately powered randomized clinical trial. The OPtimizaTIon of Left MAin PCI With IntravascuLar Ultrasound (OPTIMAL) trial has been designed to establish whether IVUS-guided PCI optimization on LMCA is associated with superior clinical outcomes when compared with standard qualitative angiography-guided PCI.

Methods

The OPTIMAL trial is a randomized, multicenter, international study designed to enroll a total of 800 patients undergoing PCI for unprotected LMCA disease. Patients will be randomized in a 1:1 fashion to IVUS-guided PCI versus angiogram-guided PCI. In patients allocated to the angiogram-guided arm, use of IVUS is discouraged, unless there are safety concerns. In patients allocated to the IVUS guidance arm, pre-procedural IVUS assessment is highly recommended, whilst post-procedural IVUS assessment is mandatory to confirm appropriate stenting result and/or to guide stent result optimization, according to predefined criteria. Patients will be followed up to 2 years after the index procedure. The primary outcome measure is the Academic Research Consortium (ARC) patient-oriented composite endpoint (PoCE) which includes all-cause death, any stroke, any myocardial infarction and any repeat revascularization at 2 years follow-up.

Discussion

The OPTIMAL trial aims to provide definitive evidence about the clinical impact of IVUS-guidance during PCI to an unprotected LMCA. It is anticipated by the investigators, that an IVUS-guided strategy will be associated with less clinical events compared to a strategy guided by angiogram alone.

Trial registration

ClinicalTrials.gov: NCT04111770. Registered on October 1, 2019.
Improved log-Gaussian approximation for over-dispersed Poisson regression: Application to spatial analysis of COVID-19
Authors: Murakami Daisuke , Matsui Tomoko
Published: January 2022

In the era of open data, Poisson and other count regression models are increasingly important. Still, conventional Poisson regression has remaining issues in terms of identifiability and computational efficiency. Especially, due to an identification problem, Poisson regression can be unstable for small samples with many zeros. Provided this, we develop a closed-form inference for an over-dispersed Poisson regression including Poisson additive mixed models. The approach is derived via mode-based log-Gaussian approximation. The resulting method is fast, practical, and free from the identification problem. Monte Carlo experiments demonstrate that the estimation error of the proposed method is a considerably smaller estimation error than the closed-form alternatives and as small as the usual Poisson regressions. For counts with many zeros, our approximation has better estimation accuracy than conventional Poisson regression. We obtained similar results in the case of Poisson additive mixed modeling considering spatial or group effects. The developed method was applied for analyzing COVID-19 data in Japan. This result suggests that influences of pedestrian density, age, and other factors on the number of cases change over periods.
Understanding the epidemiological HIV risk factors and underlying risk context for youth residing in or originating from the Middle East and North Africa (MENA) region: A scoping review of the literature
Authors: Kteily-Hawa Roula , Hawa Aceel Christina , Gogolishvili David , Al Akel Mohammad , Andruszkiewicz Nicole , Vijayanathan Haran , Loutfy Mona
Published: January 2022

Introduction

HIV is the second leading cause of death among young people globally, and adolescents are the only group where HIV mortality is not declining. Middle East and North Africa (MENA) is one of few regions seeing rapid increase of HIV infections (31.0%) since 2001. MENA youth are at particular risk of HIV due to dearth of research and challenges in accessing services.

Objective

The purpose of this scoping review is to establish the epidemiological HIV risk factors and underlying risk context for youth residing in or originating from the MENA region.

Methods

Online database searches were conducted using combination of search terms. Screening 5,853 citations, published between 1990–2019 with age groups 16 to 29, resulted in 57 studies included across 18 MENA countries.

Results

‘Key populations’ engage in risky behaviors, including: overlapping risky behaviors among youth who inject drugs (PWID); lack of access to HIV testing, condomless sex, and multiple sex partners among young men who have sex with men (MSM); and high and overlapping risk behaviors among young sex workers. Challenges facing other youth groups and bridging populations include: peer pressure, inhibition about discussing sexual health, lack of credible sex education sources, low condom use, and lack of access to HIV protection/prevention services, especially testing.

Conclusion

Poor surveillance coupled with scarcity of rigorous studies limit what is known about epidemiology of HIV among youth in MENA. Homophobia, stigma around PWID, and illegal status of sex work promote non-disclosure of risk behaviors among youth and curtail serving this population.
A 3-D groundwater isoscape of the contiguous USA for forensic and water resource science
Authors: Bowen Gabriel J. , Guo Jessica S. , Allen Scott T.
Published: January 2022

A wide range of hydrological, ecological, environmental, and forensic science applications rely on predictive “isoscape” maps to provide estimates of the hydrogen or oxygen isotopic compositions of environmental water sources. Many water isoscapes have been developed, but few studies have produced isoscapes specifically representing groundwaters. None of these have represented distinct subsurface layers and isotopic variations across them. Here we compiled >6 million well completion records and >27,000 groundwater isotope datapoints to develop a space- and depth-explicit water isoscape for the contiguous United States. This 3-dimensional model shows that vertical isotopic heterogeneity in the subsurface is substantial in some parts of the country and that groundwater isotope delta values often differ from those of coincident precipitation or surface water resources; many of these patterns can be explained by established hydrological and hydrogeological mechanisms. We validate the groundwater isoscape against an independent data set of tap water values and show that the model accurately predicts tap water values in communities known to use groundwater resources. This new approach represents a foundation for further developments and the resulting isoscape should provide improved predictions of water isotope values in systems where groundwater is a known or potential water source.
Can open-defecation free (ODF) communities be sustained? A cross-sectional study in rural Ghana
Authors: Delaire Caroline , Kisiangani Joyce , Stuart Kara , Antwi-Agyei Prince , Khush Ranjiv , Peletz Rachel
Published: January 2022

Community-led total sanitation (CLTS) is a widely used approach to reduce open defecation in rural areas of low-income countries. Following CLTS programs, communities are designated as open defecation free (ODF) when household-level toilet coverage reaches the threshold specified by national guidelines (e.g., 80% in Ghana). However, because sanitation conditions are rarely monitored after communities are declared ODF, the ability of CLTS to generate lasting reductions in open defecation is poorly understood. In this study, we examined the extent to which levels of toilet ownership and use were sustained in 109 communities in rural Northern Ghana up to two and a half years after they had obtained ODF status. We found that the majority of communities (75%) did not meet Ghana’s ODF requirements. Over a third of households had either never owned (16%) or no longer owned (24%) a functional toilet, and 25% reported practicing open defecation regularly. Toilet pit and superstructure collapse were the primary causes of reversion to open defecation. Multivariate regression analysis indicated that communities had higher toilet coverage when they were located further from major roads, were not located on rocky soil, reported having a system of fines to punish open defecation, and when less time had elapsed since ODF status achievement. Households were more likely to own a functional toilet if they were larger, wealthier, had a male household head who had not completed primary education, had no children under the age of five, and benefitted from the national Livelihood Empowerment Against Poverty (LEAP) program. Wealthier households were also more likely to use a toilet for defecation and to rebuild their toilet when it collapsed. Our findings suggest that interventions that address toilet collapse and the difficulty of rebuilding, particularly among the poorest and most vulnerable households, will improve the longevity of CLTS-driven sanitation improvements in rural Ghana.
Thainema gen. nov. (Leptolyngbyaceae, Synechococcales): A new genus of simple trichal cyanobacteria isolated from a solar saltern environment in Thailand
Authors: Rasouli-Dogaheh Somayeh , Komárek Jiří , Chatchawan Thomrat , Hauer Tomáš
Published: January 2022

Simple trichal types constitute a group of cyanobacteria with an abundance of novel, often cryptic taxa. Here, we investigated material collected from wet surface-soil in a saline environment in Petchaburi Province, central Thailand. A morphological comparison of the isolated strain with similar known species, as well as its phylogenetic and species delimitation analyses based on the combined datasets of other related organisms, especially simple trichal cyanobacteria, revealed that the material of this study represented an independent taxon. Using a multifaceted method, we propose that this material represents a new genus, Thainema gen. nov., belonging to the family Leptolyngbyaceae, with the type species Thainema salinarum sp. nov. This novel taxon shares similar ecological habitats with strains previously placed in the same lineage.
Exploratory content analysis of direct-to-consumer pet genomics: What is being marketed and what are consumers saying?
Authors: Bennett Nikki E. , Mirabal Torres Silvio Ernesto , Gray Peter B.
Published: January 2022

Mars Petcare introduced the first direct-to-consumer domestic dog genetic test in 2009 and Basepaws introduced the first direct-to-consumer cat genetic test in 2016. Social science research has evaluated numerous aspects of the human direct-to-consumer market, yet no such exploration has evaluated the occurrence of pet owners pursuing pet genetic tests. Using a mixed methods approach, we conducted an exploratory content analysis of direct-to-consumer pet genetic company webpages and consumer reviews shared on Amazon. Initial data reviews indicated some companies may be key industry players, relative to others. Our results present content frequency for each group (key industry players, all other companies), though the primary themes for each remained the same. Analysis showed genetic companies are primarily sharing product and purchasing information, along with trustworthiness to establish the merit of the company and their products. Companies also used statements directed towards pet owners that are suggestive of both pets and “pet parents” benefiting from the test results. The primary themes identified in consumer reviews involved consumers sharing their perception about the tests (e.g., accuracy), what aspects of the test results they focused on (e.g., breed information), and experiences with using the test (e.g., ease of use). Amazon reviews were primarily positive, though the companies with smaller review numbers had higher percentages of negative and ambiguous sentiments. Of interest, reviews most often indicated tests were being used to determine a pet’s breed identity, while companies most frequently promoted the health advantages of using their products. Reviews revealed some consumers respond to tests by sharing their pet’s results with someone or by altering their pet’s care. Considering these results in addition to the growing popularity of this industry and the advancements of genomic technology, further research is needed to determine the role pet genetic testing may have in society and on human-animal relationships.
Influence of slope incline on the ejection of two-phase soil splashed material
Authors: Beczek Michał , Ryżak Magdalena , Mazur Rafał , Sochan Agata , Polakowski Cezary , Bieganowski Andrzej
Published: January 2022

Soil splash is the first step in the process of water erosion, where impacting raindrops cause the detachment and transport of soil material. One of the factors that strongly influences the magnitude of soil splash is the incline of the surface (slope). The aim of this study was to investigate the effect of the slope on the course of the splash phenomenon caused by single-drop impact (one drop impact per soil sample), with respect to the mass and proportions of the ejected material, taking into account its division into solid and liquid phases i.e. soil and water. The investigation was carried out using three types of soil with different textures, in moistened (pressure head corresponding to -1.0 kPa) and air-dry (-1500 kPa) conditions. The soil samples were on three angles of slope, being 5°, 15°, and 30°, respectively. After a single-drop impact with a diameter of 4.2 mm, the ejected material was collected using a splash cup. The following quantities of splashed material were measured: the total mass, the mass of the solid phase, and the mass of the liquid phase. Additionally, the distribution and proportions (soil/water) of the splashed material were analysed in both the upslope and downslope directions. It was found that: (i) the change of slope had a variable influence on the measured quantities for different soils; (ii) in the case of moistened samples, the measured values were mainly influenced by the texture, while in the dry samples, by the angle of the slope; (iii) with the increase of slope, the splashed material was mostly ejected in the downslope direction (irrespective of moisture conditions); (iv) in the moistened samples, the ejected material consisted mostly of water, while in the dry samples it was soil—this occurred for material ejected both upslope and downslope. The obtained results are important for improving the physical description of the process of splash erosion. A more thorough understanding and better recognition of the mechanisms governing this phenomenon at all stages could contribute to the development of more effective methods for protecting soil against erosion.
Comparison between 20 and 30 meters in walkway length affecting the 6-minute walk test in patients with chronic obstructive pulmonary disease: A randomized crossover study
Authors: Saiphoklang Narongkorn , Pugongchai Apiwat , Leelasittikul Kanyada
Published: January 2022

Background

A 30-m walkway length for the 6-minute walk test (6MWT) is the standard recommendation established by the American Thoracic Society to assess patients with chronic obstructive pulmonary disease (COPD). This study aimed to compare between the distances of 20 and 30 m long corridor affecting 6MWT in COPD patients.

Methods

A randomized crossover study was conducted with patients. COPD patients were randomized 1:1 to either a 20-m or a 30-m walkway in the first test, then switched to the other in the second test. Physiologic parameters and 6-minute walking distance (6MWD) were recorded.

Results

Fifty subjects (92% men) were included: age 69.1±7.4 years, body mass index 22.9±5.5 kg/m2, FEV1 63.0±21.3%, and 50% having cardiovascular disease. The 6MWD in a 20-m and a 30-m walkway were 337.82±71.80 m and 359.85±77.25 m, respectively (P<0.001). Mean distance difference was 22.03 m (95% CI -28.29 to -15.76, P<0.001). Patients with a 20-m walkway had more turns than those with a 30-m walkway (mean difference of 4.88 turns, 95% CI 4.48 to 5.28, P<0.001). Also, higher systolic blood pressure was found in patients with a 20-m walkway after 6MWT (4.62 mmHg, P = 0.019). Other parameters and Borg dyspnea scale did not differ.

Conclusions

The walkway length had significant effect on walking distance in COPD patients. A 30-m walkway length should still be recommended in 6MWT for COPD assessment.

Clinical trial registration

Clinicaltrials.in.th number: TCTR20200206003.
MARIDA: A benchmark for Marine Debris detection from Sentinel-2 remote sensing data
Authors: Kikaki Katerina , Kakogeorgiou Ioannis , Mikeli Paraskevi , Raitsos Dionysios E. , Karantzalos Konstantinos
Published: January 2022

Currently, a significant amount of research is focused on detecting Marine Debris and assessing its spectral behaviour via remote sensing, ultimately aiming at new operational monitoring solutions. Here, we introduce a Marine Debris Archive (MARIDA), as a benchmark dataset for developing and evaluating Machine Learning (ML) algorithms capable of detecting Marine Debris. MARIDA is the first dataset based on the multispectral Sentinel-2 (S2) satellite data, which distinguishes Marine Debris from various marine features that co-exist, includingSargassum macroalgae,Ships,Natural Organic Material,Waves,Wakes,Foam, dissimilar water types (i.e.,Clear,Turbid Water,Sediment-Laden Water,Shallow Water), andClouds. We provide annotations (georeferenced polygons/ pixels) from verified plastic debris events in several geographical regions globally, during different seasons, years and sea state conditions. A detailed spectral and statistical analysis of the MARIDA dataset is presented along with well-established ML baselines for weakly supervised semantic segmentation and multi-label classification tasks. MARIDA is an open-access dataset which enables the research community to explore the spectral behaviour of certain floating materials, sea state features and water types, to develop and evaluate Marine Debris detection solutions based on artificial intelligence and deep learning architectures, as well as satellite pre-processing pipelines.
Emotions and emotion up-regulation during the COVID-19 pandemic in Germany
Authors: Schelhorn Iris , Schlüter Swantje , Paintner Kerstin , Shiban Youssef , Lugo Ricardo , Meyer Marie , Sütterlin Stefan
Published: January 2022

In stressful situations such as the COVID-19-pandemic, unpleasant emotions are expected to increase while pleasant emotions will likely decrease. Little is known about the role cognitive appraisals, information management, and upregulating pleasant emotions can play to support emotion regulation in a pandemic. In an online survey (N = 1682), we investigated predictors of changes in pleasant and unpleasant emotions in a German sample (aged 18–88 years) shortly after the first restrictions were imposed. Crisis self-efficacy and felt restriction were predictors of changes in unpleasant emotions and joy alike. The application of emotion up-regulation strategies was weakly associated with changes in joy. Among the different upregulation strategies, only “savouring the moment” predicted changes in joy. Our study informs future research perspectives assessing the role of upregulating pleasant emotions under challenging circumstances.
Intention and practice on breastfeeding among pregnant mothers in Malaysia and factors associated with practice of exclusive breastfeeding: A cohort study
Authors: Shohaimi Nurul Mursyidah , Mazelan Majidah , Ramanathan Kanesh , Meor Hazizi Mai Shahira , Leong Yan Ning , Cheong Xiang Bin , Ambigapathy Subashini , Cheong Ai Theng
Published: January 2022

Background

Exclusive breastfeeding rate in Malaysia is low despite its known health benefits. This study aims to determine the prevalence of intention to breastfeed among pregnant mothers, the prevalence of exclusive breastfeeding practice after delivery, and factors associated with exclusive breastfeeding practice.

Methods

This was a prospective cohort study. All pregnant women at 36 weeks gestation or above from 17 antenatal health clinics in an urban district were invited to participate in the study. A self-administered questionnaire was used, encompassing sociodemographic, breastfeeding knowledge, attitude, and intention towards the practice of breastfeeding. The participants were followed up one month post-natal for their practice of breastfeeding via telephone or during their post-natal follow-up appointment.

Results

483 pregnant mothers participated in the study initially. 462 (95.7%) were contactable after one month. 99.4% (459/462) of participants intended to breastfeed. 65.4% (302/462) of participants practiced exclusive breastfeeding. There was no significant association between intention and practice of exclusive breastfeeding. Multiple logistic regression analysis shows, pregnant mothers with high breastfeeding knowledge (AOR = 1.138; 95% CI 1.008–1.284) and Malay ethnicity (AOR = 2.031; 95% CI 1.066–3.868) were more likely to breastfeed their infant exclusively.

Conclusions

Prevalence of exclusive breastfeeding practice at one month in the studied district was 65.4%. Malay mothers and mothers with high breastfeeding knowledge were more likely to breastfeed exclusively. Thus, we recommend targeted intervention towards non-Malay mothers and increasing breastfeeding knowledge to all pregnant mothers.
Clinical efficacy of nivolumab is associated with tertiary lymphoid structures in surgically resected primary tumors of recurrent gastric cancer
Authors: Mori Takuya , Tanaka Hiroaki , Deguchi Sota , Yamakoshi Yoshihito , Miki Yuichiro , Yoshii Mami , Tamura Tatsuro , Toyokawa Takahiro , Lee Shigeru , Muguruma Kazuya , Ohira Masaichi
Published: January 2022

Nivolumab, an immune checkpoint blocker, has been approved for advanced gastric cancer (GC), but predictive factors of nivolumab’s efficacy in patients with GC, especially immune cells such as tissue-resident memory T cells or those forming tertiary lymphoid structures (TLS), remain unclear. Tissue samples were obtained from surgically resected specimens of patients with GC who were treated with nivolumab as third-line or later treatment. Immunohistochemical staining was performed to detect the presence of TLS and CD103+T cells and assess the association between TLSs and response to nivolumab treatment. A total of 19 patients were analyzed. In patients with partial response (PR) to nivolumab, numerous TLS were observed, and CD103+T cells were found in and around TLS. Patients with many TLS experienced immune-related adverse events more often than those with few TLS (p= 0.018). The prognosis of patients with TLS high was better than those with TLS low. Patients with a combination of TLS high and CD103 high tended to have a better prognosis than other groups. Our results suggested that TLS status might be a predictor of nivolumab effectiveness.
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium
Authors: Gagliardi Talita B. , Goldstein Monty E. , Song Daniel , Gray Kelsey M. , Jung Jae W. , Ignacio Maxinne A. , Stroka Kimberly M. , Duncan Gregg A. , Scull Margaret A.
Published: January 2022

The clinical impact of rhinovirus C (RV-C) is well-documented; yet, the viral life cycle remains poorly defined. Thus, we characterized RV-C15 replication at the single-cell level and its impact on the human airway epithelium (HAE) using a physiologically-relevant in vitro model. RV-C15 replication was restricted to ciliated cells where viral RNA levels peaked at 12 hours post-infection (hpi), correlating with elevated titers in the apical compartment at 24hpi. Notably, infection was associated with a loss of polarized expression of the RV-C receptor, cadherin-related family member 3. Visualization of double-stranded RNA (dsRNA) during RV-C15 replication revealed two distinct replication complex arrangements within the cell, likely corresponding to different time points in infection. To further define RV-C15 replication sites, we analyzed the expression and colocalization of giantin, phosphatidylinositol-4-phosphate, and calnexin with dsRNA. Despite observing Golgi fragmentation by immunofluorescence during RV-C15 infection as previously reported for other RVs, a high ratio of calnexin-dsRNA colocalization implicated the endoplasmic reticulum as the primary site for RV-C15 replication in HAE. RV-C15 infection was also associated with elevated stimulator of interferon genes (STING) expression and the induction of incomplete autophagy, a mechanism used by other RVs to facilitate non-lytic release of progeny virions. Notably, genetic depletion of STING in HAE attenuated RV-C15 and -A16 (but not -B14) replication, corroborating a previously proposed proviral role for STING in some RV infections. Finally, RV-C15 infection resulted in a temporary loss in epithelial barrier integrity and the translocation of tight junction proteins while a reduction in mucociliary clearance indicated cytopathic effects on epithelial function. Together, our findings identify both shared and unique features of RV-C replication compared to related rhinoviruses and define the impact of RV-C on both epithelial cell organization and tissue functionality–aspects of infection that may contribute to pathogenesis in vivo.
Stakeholders' Perception of the Introduction of Specialized Hospitals for Urologic Diseases: Qualitative Study
Authors: Jeong Hye-Ran , Pyo Jee-Hee , Choi Eun-Young , Kim Ju-Young , Park Young-Kwon , Ock Min-Su , Lee Won , Lee Sang-Il
Published: January 2022

Purpose:The purpose of this study is to seek in-depth perspectives of stakeholders on the necessity and specific criteria for designating a specialized hospital for urologic diseases.Methods: Eight participants experts in urology medicine and specialized hospital system were divided into four groups. Following the semi-structured guidelines, an in-depth interview was conducted twice and a focus group discussion was conducted three times. All the interviews were transcribed verbatim and analyzed.Results: The majority of participants predicted that there would be demand for specialized hospitals for urologic diseases. The criteria of designating a specialized hospital, such as the number of hospital beds and quality of health care, have to be modified in consideration of the specificity of urology. The introduction of a specialized hospital would improve the healthcare delivery system, positively affecting hospitals and patients. Furthermore, government support is essential for the maintenance of specialized hospital systems as urology hospitals experience difficulties in generating profits.Conclusion: This study is expected to be used as base data for introducing and operating a specialized hospital for urologic diseases. In addition, it is expected that the methodology and results of this study would encourage follow-up studies on specialized hospitals and provide guidelines to evaluate the effectiveness of such hospitals in other medical fields.
Manejos subjetivos na formação de professores
Authors: Geffard Patrick , Tavares Carla Nunes Vieira
Published: January 2022

Desenvolvida na França entre 1950 e 1960 por pedagogos, psiquiatras e psicanalistas, a pedagogia institucional aposta nas trocas e nas mediações em grupo e na noção de coletivo, promovendo atividades e dinâmicas diversas para desencadear a reciprocidade e acirrar a dialogicidade na criação de saídas de conflitos e impasses no ambiente escolar e de formação. Ainda pouco conhecida no Brasil em seu viés mais atravessado pela psicanálise, essa corrente pedagógica se vale da premissa da divisão subjetiva para discutir questões de ensino-aprendizagem e de formação de professores, dando enfoque particular a situações em que a subjetividade se deixa flagrar nas práticas pedagógicas. Para esse ponto também convergem os estudos discursivos franco-brasileiros, que semelhantemente se deixam afetar pela psicanálise freudo-lacaniana e se interessam pela mesma temática. A entrevista que se segue resultou de uma missão de pesquisa com o Prof. XXXX, na Universidade YYYY, em 2019. Ela materializa um diálogo profícuo entre dois pesquisadores de campos distintos, interessados nos mesmos temas, abordando a importância da prática linguageira nos dispositivos que privilegiam formas de subjetivação na formação de professores e a relação entre linguagem e subjetividade.
Semântica Cultural e Diversidade Linguística Regional
Authors: Rodrigues Liska Geraldo José , Correia Breno Oliveira
Published: January 2022

Este artigo apresenta uma análise cultural do falar de uma das cidades do sul do estado de Minas Gerais, Campo do Meio. Informações sobre topônimos, tradições orais e expressões idiomáticas foram coletadas entre os falantes do munícipio a fim de demonstrar as peculiaridades linguísticas desse povo interiorano. Para isto, foi utilizado como referencial teórico a Semântica de Contextos e Cenários (SCC), concepção de semântica que toma como base a ideia de que uma língua natural é um sistema socializado e culturalmente determinado de representação de mundos e seus eventos. A pesquisa, realizada em etapas, culminou nos seguintes procedimentos: coleta de material bibliográfico, seleção de materiais, entrevistas e transcrição de dados.  Buscamos demonstrar um trabalho sobre estudos linguísticos de caráter cultural e resgatar um pouco da cultura de um povo, perdida dia após dia.
Hydrological response of hydrographic sub-basins in the Piracicaba River Basin - Southeast Region of Brazil
Authors: Carvalho Ana Claudia Pereira , Lorandi Reinaldo , Lollo José Augusto Di , Collares Eduardo Goulart , Moschini Luiz Eduardo
Published: January 2022

Use of water for several human needs, associated with climate change, indicates the need understand the response of watersheds, in order to provide adequate water resources planning and management. This study was carried out in two pairs of hydrographic watersheds, in the Piracicaba River Basin, southeast of Brazil, analyzing water response, integrating in-situ collected precipitation and flow data, natural environment attributes, and anthropic environmental data. To support the analysis, Surface Runoff Potential Charts (SRPC). The evaluation of the physical characteristics of the sub watersheds (SW(A) and SW(B)) shows that these areas present very low to low potential, indicating greater infiltration capacity. The use and coverage of the soil partially justifies the flow changes in pair 1, since SW(A) has a larger extent of agricultural areas that can use irrigation. SW(B), even with a greater variety of crops, has a smaller cultivated area and tends to demand less water. At pair 2, the low runoff potential is mainly due to the predominance of flat relief in the sub-basins. The soils that compose them present a higher fraction of silt and clay, with thicknesses > 5m in SW(C) and varying from 0.5m, reaching depths above 5m in SW(D), however, the physical properties of these soils do not provide a low flow rate, but associated with the low slope of the land, the geological characteristics and low drainage density are configured in regions where the flow flows more slowly, contributing to the evaporation and infiltration process. The use and coverage of the soil also partially justifies the flow oscillations, due to anthropic activities in SW(C) and SW(D), such as irrigation and spraying of citrus, fertirrigation of sugarcane, irrigation of seedling nurseries, directly interfering with the availability of surface water.
TOTARO, Rebecca. 2020. The Plague in Print: Essential Elizabethan Sources, 1558–1603.
Authors: Gossett Suzanne
Published: January 2022

Review.
TURPIN, Zachary and Matt MILLER, eds. 2020. Every Hour, Every Atom: A Collection of Walt Whitman’s Early Notebooks & Fragments.
Authors: Cohen Matt
Published: January 2022

Review.
Philosophy of the Deed. “Praxis” in Hegel and Posthegelian Discourses
Authors: Arndt Andreas
Published: January 2022

In his Prolegomena to Historiosophy, published in 1838, August von Cieszkowski wrote that we are at the turning point in history, when facts turn into deeds. This raises the question of what is actually to be understood by the term “deed” [Tat] and why, the hour of the deed should have come precisely now. After focusing on Hegel’s concept of a history of freedom, I will present two models of understanding action and conclude by discussing their consequences. More specifically, I will undertake a search that will lead us – by way of a detour via Hegel’s Phenomenology of Spirit – to Fichte’s concept of the act of doing. That socio-political practice can be justified in this way, however, is denied by those who argue that society and politics in Hegel fall under the category of objective and not of absolute spirit. The alternative model of action that I will focus on, concerns action in relation to objects, or labour, a model that Hegel had already worked out in Jena, and that Marx will re-discover (rather than invent) and further develop.
Stresses and deformations of an osteosynthesis plate in a lateral tibia plateau fracture
Authors: Münch Matthias , Barth Tobias , Studt Annika , Dehoust Julius , Seide Klaus , Hartel Maximilian , Frosch Karl-Heinz
Published: January 2022

This study has the aim to investigate the strain and stress in an anterolateral locking plate applied for the fixation of a lateral split fracture. To simulate a complex fracture situation, three segments were separated. With a FEM analysis, representative places for strain and stress measurement were determined. A locked osteosynthesis plate was instrumented with strain gauges and tested on a fractured and a non-fractured Saw Bone model. To simulate different loading situations, four different points of force application, from the center of the condyles to a 15 mm posterior position, were used with a medial-lateral load distribution of 60:40. The simulations as well as the biomechanical tests demonstrated that two deformations dominate the load on the plate: a bending into posterior direction and a bulging of the plate head. Shifting the point of application to the posterior direction resulted in increasing maximum stress, from 1.16 to 6.32 MPa (FEM analysis) and from 3.04 to 7.00 MPa (biomechanical study), respectively. Furthermore, the comparison of the non-fractured and fractured models showed an increase in maximum stress by the factor 2.06–2.2 (biomechanical investigation) and 1.5–3.3 (FEM analysis), respectively.
Dynamic performance of optimized microwave assisted extraction to obtain Eucalyptus essential oil: energy requirements and environmental impact
Authors: Lainez-Cerón Elizabeth , López-Malo Aurelio , Palou Enrique , Ramírez-Corona Nelly
Published: January 2022

The dynamic performance of a microwave-assisted extraction (MAE) was studied during the extraction of eucalyptus essential oil. The effect of different process variables such as solid/liquid ratio (1:1, 1:3, or 1:5), stirring speed (0, 200, or 400 rpm), and power microwave output (360, 450, or 540 W) on obtained yield, energy requirements and environmental impact were assessed. The maximum yield was 1.26 ± 0.01% and the steam generation velocities between 4.8 and 8.8 g/min favor the extraction. In terms of environmental impact, the lowest EI99 value obtained was 6.93 ± 0.1 mPT/g. A multi-response optimization was performed to identify the operating conditions that maximize yield, while minimize energy requirements and environmental impact. Temperature dynamics and extraction kinetics were fitted to a second-order transfer function model, aimed to evaluate the role of heating patterns on the process performance. Finally, a controlled temperature experiment was carried out under the optimal conditions.
Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
Authors: Taha Mona Mohamed , Mahdy-Abdallah Heba , Shahy Eman Mohamed , Mansour Nevine Abd El-Maksoud , Fouad Marwa Mohamed , Helmy Mona Adel
Published: January 2022

Objectives

Type 2 diabetes mellitus (T2DM) represents a serious public health problem. Environmental toxins, other than infectious agents or exposures can stimulate immune responses which are associated with the occurrence of T2DM. Diabetic nephropathy (DN) is a serious complication of diabetes that leads to changes in the structure and function of the kidneys. The study aimed to detect diagnostic biomarkers for (DN), at an early stage, to prevent disease progression in these patients and improve their outcomes.

Methods

This study was performed on 102 T2DM patients and 80 normal controls. Blood glucose, HbA1c, serum homocysteine (Hcy) and urinary periostin were assessed. Patients were divided into: controlled (n=46) (HbA1c <6.5%) and uncontrolled diabetics (n=56) (HbA1c >6.5%).

Results

The study results revealed a significant rise in blood glucose and HbA1c as well as serum Hcy levels in diabetic groups compared to controls. Also, urinary periostin exhibited significant elevation in diabetic groups. Serum glucose, HbA1c and serum Hcy revealed a highly significant difference between diabetic subgroups and control groups, while urinary periostin demonstrated a non-significant difference. Only, urinary periostin showed a significant increase in uncontrolled diabetics.

Conclusions

The highest levels of serum Hcy and urinary periostin were recorded only in the uncontrolled diabetics. Urinary periostin was demonstrated as a more preferable biomarker being a non-invasive sample for predicting renal insult in diabetic subjects. This biomarker could be performed regularly for early detection of DN. Also, it could be added to the periodic medical examinations of workers occupationally exposed to workplace pollutants inducing diabetes.
Effect of optical pulse shaping and adaptive equalization on the performance of 100G DP-QPSK WDM system
Authors: Sharma Neeraj
Published: January 2022

Dual polarization quadrature phase shifting keying (DP-QPSK) modulation format along with coherent receiver helps in increasing the data carrying capability of existing optical networks without any major change in existing transmission infrastructure. The various linear and nonlinear fiber effects, frequency and phase errors are corrected in electrical domain at the receiver end with digital back propagation algorithms (DBP) instead of in-line compensation. In such a case the selection of optimum values of system parameters make the task easier for DBP algorithms. This paper highlights the importance of finding optimum operating point of continuous modulus algorithm (CMA) for better adaptive equalization (AE). The paper also discusses the optical pulse shaping using Gaussian optical band-pass filter to improve the spectral characteristics of DP-QPSK signal.
Degeneration and Entropy
Authors: Chua Eugene Y. S.
Published: January 2022

Lakatos’s analysis of progress and degeneration in the Methodology of Scientific Research Programmes is well-known. Less known, however, are his thoughts on degeneration in Proofs and Refutations. I propose and motivate two new criteria for degeneration based on the discussion in Proofs and Refutations – superfluity and authoritarianism. I show how these criteria augment the account in Methodology of Scientific Research Programmes, providing a generalized Lakatosian account of progress and degeneration. I then apply this generalized account to a key transition point in the history of entropy – the transition to an information-theoretic interpretation of entropy – by assessing Jaynes’s 1957 paper on information theory and statistical mechanics.
Classification of f-biharmonic submanifolds in Lorentz space forms
Authors: Du Li
Published: January 2022

In this paper, f-biharmonic submanifolds with parallel normalized mean curvature vector field in Lorentz space forms are discussed. When

f

f

is a constant, we prove that such submanifolds have parallel mean curvature vector field with the minimal polynomial of the shape operator of degree

≤
2

\le 2

. When

f

f

is a function, we completely classify such pseudo-umbilical submanifolds.
Optical metasurfaces for generating and manipulating optical vortex beams
Authors: Ahmed Hammad , Kim Hongyoon , Zhang Yuebian , Intaravanne Yuttana , Jang Jaehyuck , Rho Junsuk , Chen Shuqi , Chen Xianzhong
Published: January 2022

Optical vortices (OVs) carrying orbital angular momentum (OAM) have attracted considerable interest in the field of optics and photonics owing to their peculiar optical features and extra degree of freedom for carrying information. Although there have been significant efforts to realize OVs using conventional optics, it is limited by large volume, high cost, and lack of design flexibility. Optical metasurfaces have recently attracted tremendous interest due to their unprecedented capability in the manipulation of the amplitude, phase, polarization, and frequency of light at a subwavelength scale. Optical metasurfaces have revolutionized design concepts in photonics, providing a new platform to develop ultrathin optical devices for the realization of OVs at subwavelength resolution. In this article, we will review the recent progress in optical metasurface-based OVs. We provide a comprehensive discussion on the optical manipulation of OVs, including OAM superposition, OAM sorting, OAM multiplexing, OAM holography, and nonlinear metasurfaces for OAM generation and manipulation. The rapid development of metasurface for OVs generation and manipulation will play an important role in many relevant research fields. We expect that metasurface will fuel the continuous progress of wearable and portable consumer electronics and optics where low-cost and miniaturized OAM related systems are in high demand.
State-of-the-art review of fabrication, application, and mechanical properties of functionally graded porous nanocomposite materials
Authors: Barbaros Ismail , Yang Yongmin , Safaei Babak , Yang Zhicheng , Qin Zhaoye , Asmael Mohammed
Published: January 2022

Functionally graded porous (FGP) nanocomposites are the most promising materials among the manufacturing and materials sector due to their adjustable physical, mechanical, and operational properties for distinctive engineering applications for maximized efficiency. Therefore, investigating the underlying physical and materialistic phenomena of such materials is vital. This research was conducted to analyze the preparation, fabrication, applications, and elastic properties of functionally graded materials (FGMs). The research investigated for both porous and nonporous synthesis, preparation, and manufacturing methods for ceramics, metallic, and polymeric nanocomposites in the first section, which is followed by deep research of the development of elastic properties of the above-mentioned materials. Main nano-reinforcing agents used in FGMs to improve elastic properties were found to be graphene platelets, carbon nanotubes, and carbon nanofibers. In addition, research studied the impact of nano-reinforcing agent on the elastic properties of the FGMs. Shape, size, composition, and distribution of nano-reinforcing agents were analyzed and classified. Furthermore, the research concentrated on modeling of FGP nanocomposites. Extensive mathematical, numerical, and computational modeling were analyzed and classified for different engineering analysis types including buckling, thermal, vibrational, thermoelasticity, static, and dynamic bending. Finally, manufacturing and design methods regarding different materials were summarized. The most common results found in this study are that the addition of reinforcement units to any type of porous and nonporous nanocomposites significantly increases materialistic and material properties. To extend, compressive and tensile stresses, buckling, vibrational, elastic, acoustical, energy absorption, and stress distribution endurance are considerably enhanced when reinforcing is applied to porous and nonporous nanocomposite assemblies. Ultimately, the review concluded that the parameters such as shape, size, composition, and distribution of the reinforcing units are vital in terms of determining the final mechanical and materialistic properties of nanocomposites.