bluuebunny/crossref_metadata_2025 huggingface dataset:
The Shareholder Value Mess (And How to Clean it Up)
Authors: Robé Jean-Philippe
Published: October 2019

Shareholder Value is not only a myth, as forcefully demonstrated by Lynn Stout. It has also led to a mess under the form of extensive negative externalities and growing inequalities. A different measure of value creation is urgently required.
Introduction: Tourism spaces at the nexus of language and materiality
Authors: Lamb Gavin , Sharma Bal Krishna
Published: October 2019

This special issue builds on sociolinguistic research in tourism, semiotic landscapes, language materiality, and multilingual and multimodal practices to explore how spaces for tourism are formed at the nexus of language and the material world.
Optimal Incentives Under Gift Exchange
Authors: Khan Hayat
Published: October 2019

This paper studies optimal incentives in the presence of an agent’s preference for generosity, where the principal optimally chooses the level of generosity (rent) as well as the performance-based pay. We show that some minimum level of reciprocity is required for generous contracts to become attractive. More reciprocal agents exert greater effort, but they may not necessarily receive more generous offers, as our model predicts a hump-shaped relationship between generosity and the reciprocity parameter. This means that moderately reciprocal agents tend to receive a premium relative to weakly or strongly reciprocal agents. Generosity and performance-based pay are likely to behave as complements when risk-sharing motives (determined by noise in the environment and the agent’s degree of risk-aversion) are strong, and they are likely to behave as substitutes when risk-sharing motives are relatively moderate. Moreover, base-wage gifts are always optimal, whereas piece-rate or composite gifts are only optimal in a low-noise environment.
Folic acid decorated metal-organic frameworks loaded with doxorubicin for tumor-targeted chemotherapy of osteosarcoma
Authors: Xu Weifan , Lou Yi , Chen WangShenjie , Kang Yifan
Published: October 2019

Effective cancer therapy usually requires the assistance of well-designed drug carriers. In order to increase the drug accumulation to tumor tissue as well as to reduce the side effects of drug carriers, the hybrid drug delivery system (DDS) was developed by integrating folic acid (FA) and a metal-organic framework (MOF). The anticancer drug doxorubicin (DOX) was preloaded into the MOF nanoparticles during the synthesis process of the MOF nanoparticles. After surface modification with FA, the resulting FA/MOF/DOX nanoparticles were capable of serving as a biocompatible osteosarcoma targeting a DDS to enhance the chemotherapy of osteosarcoma. The dynamic light scattering method revealed that the obtained FA/MOF/DOX nanoparticles were particles with a size around 100 nm. Moreover, FA/MOF/DOX nanoparticles could enhance the delivery efficacy of DOX into MG63 (human osteosarcoma) cells as compared to FA free nanoparticles (MOF/DOX), in which a folate receptor (FR) might be involved. It was worth mentioning that in vitro [methylthio tetrazole (MTT) study in the MG63 cells] and in vivo (anticancer study in the MG63 xenograft model) assays both revealed that FA/MOF/DOX nanoparticles possessed stronger anticancer capability than free DOX or MOF/DOX nanoparticles.
Synthesis and antioxidant activity of 2-methylthio-pyrido[3,2-e][1,2,4] triazolo[1,5-a]pyrimidines
Authors: Abuelizz Hatem A. , Taie Hanan A.A. , Marzouk Mohamed , Al-Salahi Rashad
Published: October 2019

A series of 2-methylthio-pyrido-triazolopyrimidines (1-17) were prepared by the reaction of dimethyl-N-cyanoimidodithiocarbonate with hydrazinopyridine carboxylic acid as starting reactants. Their chemical structures were affirmed with HREI-MS, IR and NMR analyses. The target compounds (1-17) were evaluated for their antioxidant activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some pyrido-triazolopyrimidines showed good activity as antioxidant agents, in particular, compounds 12 and 15 were found to possess good antioxidant activity. Butylated hydroxyl toluene (BHT) was used as reference drug.
Is the Polish Smog a New Type of Smog?
Authors: Czerwińska Justyna , Wielgosiński Grzegorz , Szymańska Olga
Published: October 2019

In recent years, every winter we face the problem of excessive air pollution in the cities in Poland. This phenomenon is usually called smog and is associated with the concept of acidic smog of London type. However, there is a fundamental difference between the Great Smog of London known from the literature and winter smog episodes in Poland. While in 1952 in London the smog occurred at low atmospheric pressure, in foggy and windless weather conditions, in Poland smog episodes occur most often at the influx of cold, high-pressure air masses from the east in sunny weather. There are also various harmful components of smog - in London it was dust (suspended particulate matter), sulfur dioxide and carbon monoxide, while in Poland it is suspended particulate matter and polyaromatic hydrocarbons, especially benzo(a)pyrene. A common factor is the inversion of temperature in the ground level of the atmosphere. The chemical composition of the “Polish smog” is analyzed in the study justifying the need to distinguish the two types of smog described.
Bacillus subtilis BS-2 and Peppermint Oil as Biocontrol Agents Against Botrytis cinerea
Authors: Grata Katarzyna , Rombel-Bryzek Agnieszka , Ziembik Zbigniew
Published: October 2019

The purpose of this study was to assess the activity of Bacillus subtilis BS-2 and peppermint oil against Botrytis cinerea. In this study parameters such as the age and the density of the bacterial culture and the incubation temperature were taken into consideration. Furthermore, the cellulolytic activity of the bacterium was determined. The effect of peppermint oil was evaluated at a concentration range of 0.5-4.0 %. The research was conducted with a dual culture plate method. The influence of B. subtilis BS-2 and peppermint oil on the growth of B. cinerea was evaluated based on the growth rate index. It was noted that the bacterial culture occurred at an initial density of OD
560 = 1.0, cultivated at 30 °C for 48 hours demonstrated the strongest antagonistic effect (57.07 % inhibition). Furthermore, it was observed that the highest cellulolytic activity occurred on the bacteria incubated for 48 hours at 37 °C. The effect of mint oil, at the lowest concentration of 0.5-1.0 %, was much weaker on bacterial activity (1.1-12.1 % inhibition). The highest concentration (4.0 %) of mint oil caused the maximum inhibition (31.9 %) of the mycelial growth. B. subtilis BS-2 may be environmental-friendly alternatives for protecting plants against B. cinerea
Near final adult height, and body mass index in overweight/obese and normal-weight children with idiopathic central precocious puberty and treated with gonadotropin-releasing hormone analogs
Authors: Sinthuprasith Pattharaphorn , Dejkhamron Prapai , Wejaphikul Karn , Unachak Kevalee
Published: October 2019

Background

The standard treatment of central precocious puberty (CPP) is gonadotropin-releasing hormone analogues (GnRHa). It is a concern that children treated with GnRHa are at risk of developing obesity which could impair the treatment outcomes. This study aimed to investigate the effect of GnRHa on body mass index (BMI) standard deviation score (SDS), and the influence of BMI status on treatment outcomes in children with idiopathic CPP (iCPP).

Methods

A retrospective cohort study in children with iCPP who completed GnRHa treatment and had attained near final adult height (NFAH) was conducted. Children with a history of disease or drug ingestion which could affect their BMI were excluded. BMI, BMI SDS, height (Ht), Ht SDS, predicted adult height (PAH), and NFAH were compared at baseline, 1 and 2 years during treatment, and at NFAH according to the baseline BMI status; normal weight and overweight/obesity.

Results

Fifty-eight children with iCPP treated with GnRHa were enrolled. The BMI SDS was significantly increased at 1 and 2 years during treatment in the overweight/obese group and at 1 year during treatment in the normal-weight group. However, at NFAH (2 years after treatment discontinuation), the BMI SDS was not statistically different from baseline in both groups. Ht gain, change in Ht SDS and BMI SDS were not statistically different from the baseline in both groups.

Conclusions

GnRHa results in a transient increase in BMI SDS during treatment and returned to baseline after treatment cessation. The benefit of GnRHa treatment on final Ht improvement is similar between overweight/obese and normal-weight patients.
Point-of-care ultrasound for peripherally inserted central catheter monitoring: a pilot study
Authors: Motz Patrick , Von Saint Andre Von Arnim Amelie , Iyer Ramesh S. , Chabra Shilpi , Likes Maggie , Dighe Manjiri
Published: October 2019

Objective

To assess the feasibility and accuracy of point-of-care ultrasound (POCUS) in monitoring peripherally inserted central catheter (PICC) location in neonates by non-radiologist physicians.

Methods

A prospective cohort study compared PICC localization by ultrasound in neonates with a recent radiograph. The ultrasound exam was performed using a standardized protocol with 13–6 MHz linear and 8–4 MHz phased array transducers by a neonatal-perinatal fellow who was blinded to PICC location on the radiograph.

Results

Of the 30 neonates included, 96.6% (n = 29) were preterm, with 63.3% (n = 19) weighing <1500 g. Nighty-four percent (n = 94) of ultrasound scans matched the radiograph report. The protocol had a sensitivity of 0.97, specificity of 0.66 and positive predictive value of 0.98.

Conclusion

Limited ultrasound exams to monitor PICC position in neonates using a standardized protocol by non-radiologist physicians are feasible and accurate in a single ultrasound user. Further study in multiple providers is needed before widespread use.
Highly informative integrated method for determining the type of engine oil
Authors: Mamykin A. V. , Kukla A. L. , Matvienko L. M. , Dorozinska H. V. , Maslov V. P. , Dorozinsky G. V.
Published: October 2019

The presence of correlation dependences between the type of motor oil and its refractometric and electrophysical characteristics (refractive index, specific resistance and dielectric constant) is experimentally shown. Methods for determining the type of engine oil are proposed, based on the measurement of these characteristics, as well as prototypes of portable measuring devices that implement these methods. Impedance spectroscopy was used to determine the resistivity and dielectric constant, and a device based on the effect of surface plasmon resonance was used to determine the refractive index. It is shown that the accuracy of identification of the type of motor oil increases significantly with simultaneous consideration of all above physical characteristics. It is shown that this complex method can most accurately detect, on the one hand, purely synthetic motor oils, on the other hand, oils with a mineral component (semi-synthetic and mineral). The results of the studies can be used to identify the type of motor oil as well as to detect forgery.
Selecting Closely-Linked SNPs Based on Local Epistatic Effects for Haplotype Construction Improves Power of Association Mapping
Authors: Liu Fang , Schmidt Renate H , Reif Jochen C , Jiang Yong
Published: October 2019

Genome-wide association studies (GWAS) have gained central importance for the identification of candidate loci underlying complex traits. Single nucleotide polymorphism (SNP) markers are mostly used as genetic variants for the analysis of genotype-phenotype associations in populations, but closely linked SNPs that are grouped into haplotypes are also exploited. The benefit of haplotype-based GWAS approaches vs. SNP-based approaches is still under debate because SNPs in high linkage disequilibrium provide redundant information. To overcome some constraints of the commonly-used haplotype-based GWAS in which only consecutive SNPs are considered for haplotype construction, we propose a new method called functional haplotype-based GWAS (FH GWAS). FH GWAS is featured by combining SNPs into haplotypes based on the additive and epistatic effects among SNPs. Such haplotypes were termed functional haplotypes (FH). As shown by simulation studies, the FH GWAS approach clearly outperformed the SNP-based approach unless the minor allele frequency of the SNPs making up the haplotypes is low and the linkage disequilibrium between them is high. Applying FH GWAS for the trait flowering time in a large Arabidopsis thaliana population with whole-genome sequencing data revealed its potential empirically. FH GWAS identified all candidate regions which were detected in SNP-based and two other haplotype-based GWAS approaches. In addition, a novel region on chromosome 4 was solely detected by FH GWAS. Thus both the results of our simulation and empirical studies demonstrate that FH GWAS is a promising method and superior to the SNP-based approach even if almost complete genotype information is available.
„Aktivistische Leerverkäufer“ – eine Überlegung zur Markteffizienz und deren Grenzen im Kapitalmarktrecht
Authors: Langenbucher Katja , Hau Daniel , Wentz Jasper
Published: October 2019

Aktivistische Leerverkäufer standen in jüngerer Zeit häufig im Zentrum medialer Aufmerksamkeit. Ihre „Attacken“ auf börsennotierte Unternehmen bewegen sich in einem Spannungsverhältnis zwischen erwünschter Steigerung der Markteffizienz und verbotener Marktmanipulation. Soweit die von Leerverkäufern verbreiteten negativen Informationen zu besserer Markteffizienz beitragen, folgt hieraus eine Verringerung der Informationsasymmetrie zwischen Aktionären und Verwaltung, eines der zentralen Probleme des Prinzipal-Agent-Konflikts. Der aktivistische Leerverkäufer leistet dann einen positiven Beitrag zur Corporate Governance. Anderes gilt, wenn er bei seiner Verbreitung negativer Informationen die Grenze zur Marktmanipulation überschreitet. Der europäische Gesetzgeber begegnet dem einerseits mit Transparenzpflichten, andererseits mit Verbotstatbeständen. Der vorliegende Beitrag ordnet vor diesem Hintergrund das Geschäftsmodell aktivistischer Leerverkäufer ein und grenzt es von anderen Leerverkaufsstrategien ab.
Psychoanalysis and Literature, Mary's Character in Lessing's novel 'The Grass is Singing' as a Case Study"
Authors: Herouach Sofian
Published: October 2019

The “Grass is Singing” is work that depicts many issues and communicates several themes. The issue of racism is mostly apparent that it deals with the subordination of the black people and their being exploited, abused and humiliated in their lands by British white people. As embodied through the character of the farmer, Dick Turner, the black servants are treated only as slaves and savages. More important in this novel is how the author deals with the psychic life of her characters. Particularly, the female character “Mary” who’s overlapping hurtful experiences and self-unconscious troubles causes her pain and sufferance in her relationship with the outer world. This paper will, therefore, approach the character of Mary from a psychoanalytic perspective and the variables that interrelate during Mary’s successive life stages to end up in her being murdered. That is, this paper is an attempt to apply psychoanalysis to literature. It will investigate how the accumulated experiences of socio-psychological past and present suffering led Mary to develop a psychological complex and act upon it. In other words, the study will analyze how the accumulated experiences of childhood, surfaced to the front and stressed upon by the occasional adulthood events, correlate to culminate in a tragic end in her life.
KELIMPAHAN DAN KEANEKARAGAMAN KEPITING BAKAU (Scylla spp.) DI KAWASAN HUTAN BAKAU PASAR BANGGI, REMBANG
Authors: PAMBUDI Danang Setyo , Budiharjo Agung , Sunarto Sunarto
Published: October 2019

Pantai utara Rembang memiliki kawasan hutan bakau yang masih tersisa di Jawa Tengah. Salah satu habitat kepiting bakau (Scylla spp.) yang penting terdapat di pantai Pasar Banggi. Penangkapan secara intensif menggunakan alat tangkap bubu kepiting. Tingginya permintaan pasar terhadap kepiting bakau mengakibatkan aktivitas penangkapan di pantai Rembang dan sekitarnya berlangsung terus-menerus sehingga dikhawatirkan mengancam kelestariannya. Penelitian ini akan mendata dan menganalisa kelimpahan dan keanekaragaman kepiting bakau di pantai Pasar Banggi yang dilakukan pada bulan Februari-Maret 2019. Metode penelitian yang digunakan adalah line transek kuadrant. Pengamatan dilakukan pada 3 (tiga) stasiun, dimana masing-masing stasiun mempunyai 9 plot yang berukuran 10 x 10m. Pengambilan tangkapan kepiting dilakukan sebanyak 4 (empat) ulangan. Selanjutnya dihitung indek kelimpahan relatif (IKR) dan indek keanekaragaman Shannon-Winner (H’) di setiap stasiun penelitian. Hasil penelitian menunjukkan IKR di setiap stasiun relatif tinggi. Nilai tertinggi (37,74%) terdapat pada stasiun 2 dan terendah (25,16%) pada stasiun 1. Berdasarkan jenisnya, IKR tertinggi (53,5%) terdapat pada Scylla tranquebarica dan terendah (20,8%) pada jenis Scylla serrata. Indeks keanekaragaman (H’) rata-rata di semua stasiun penelitian relatif rendah. Nilai H’ tertinggi (1,060) terdapat di stasiun 2 dan terendah (0,697) di stasiun 1. Disarankan segera dilakukan pengelolaan kawasan hutan bakau di pantai Pasar Banggi sehingga sumberdaya kepiting bakau (Scylla spp.) dapat terus berkelanjutan.The north coast of Rembang have mangrove forest that remaining area in Central Java, One of the important habitat of mangrove crab (Scylla spp.) was Pasar Banggi coast. Trap net as the main fishing gear used for mangrove crab in those areas. The high market demand for the mangrove rab their sustainability. This research will record and analyze the abundance and diversity of mangrove crabs on the Banggi Market beach conducted in February-March 2019 by using quadrant transect line methods. Observation made consist of 3 (three) stations where each station has 9 plots with the size of plot of 10 x 10m. Furthermore, the relative abundance indices (IKR) and diversity indices of Shanon-Wienner (H’) were calculated for each station. The results showed that the value of IKR in each station was relatively high. The highest value (37.74%) found at station 2 and the lowest (25.165) at station 1. Based on the species caught, the highest IKR (53.5%) was species of Scylla tranquebarica and the lowest (20.8%) was Scylla serrata The average of H’ were low relativelly for all stations with the highest value (1.060) at station 2 and the lowest (0.697) at station 1. It is recommended that mangrove management be carried out in Pasarbanggi coast immediately so that the utilization of mangrove crab resources can continue.
Fitossanidade e qualidade de mudas de Eucalyptus urophylla x Eucalyptus grandis em função da aplicação de fosfito e silício
Authors: Silva Thiago Tássio de Sousa , Spada Grasiela , Faria Marianne Fidalgo de , Goulart Lívia Mara Lima , Furtado Edson Luiz , Passos José Raimundo Souza , Guerrini Iraê Amaral
Published: October 2019

RESUMO O setor florestal é um dos que mais contribui em termos sociais, econômicos e ambientais para o Brasil. Dentro deste setor, a eucaliptocultura pode ser apontada como a mais importante do segmento, com o plantio que representa 5,56 milhões de hectares. A primeira etapa do processo de implantação de florestas de eucaliptos é a produção de mudas, que no Brasil é feita por meio da clonagem, garantindo qualidade das mudas plantada no viveiro. Porém, um dos principais desafios em viveiros, é o controle de patógenos, e diante da variedade de espécies e híbridos de eucalipto que são suscetíveis a doença. A utilização do fosfito e silício podem diminuir o nível de severidade de bacteriose, e manter a uniformidade e qualidade das mudas em viveiros florestais. O objetivo deste trabalho foi avaliar o efeito da aplicação de produtos contendo fosfito e silício no controle de bacteriose, e na qualidade de mudas de Eucalyptus urograndis em um viveiro comercial. O delineamento experimental foi inteiramente casualizado e dez tratamentos (Zincazot, Fitofos-Cu, Fitofos-K, Fitofos-Zn-Mn, Silamol, Amorux, Fitofos-Cu + Terra sorb, Fitofos-K + Terra sorb, Fitofos-Zn-Mn + Terra sorb, e testemunha) com quatro repetições, sendo cada repetição uma bandeja com 176 mudas incluindo a testemunha, a qual não recebeu aplicação. As aplicações foram realizadas via foliar, iniciando-se sete dias antes da coleta das minicepas no mini jardim clonal até os 120 dias de idade das mudas. Os resultados foram comparados pelo teste de Tukey a 5% de probabilidade. Conclui-se que a aplicação de produtos contendo fosfito e silício não reduziu a severidade da bacteriose causada por Xanthonomas sp. em mudas de Eucalyptus urograndis a nível de viveiro. Não houve efeito significativo dos tratamentos nos padrões de qualidade avaliados. Aos 120 dias de idade foi observado, exceto na testemunha, que os tratamentos tiveram uma maior taxa de sobrevivência das mudas adequada, podendo constatar o efeito positivo dos tratamentos nessa variável que é de grande importância econômica em um viveiro de produção mudas.
Performance of chlorothalonil levels and spraying intervals on Asian rust control and soybean grain yield
Authors: Reis Erlei Melo , Zanatta Mateus , Reis Andrea Camargo
Published: October 2019

ABSTRACT In an experiment conducted in the field, during the 2017/18 growing season, with the soybean cultivar Syn 1561 IPRO, the interaction of chlorothalonil levels with application intervals was evaluated for the control of Asian soybean rust, caused by Phakopsora pachyrhizi. The first fungicide application was performed in V8 stage, 44 days after emergence, with 1.85% rust leaflet incidence. The experiment consisted of a factorial arrangement with five fungicide levels (1.0, 1.5, 2.0, 2.5 and 3.0 L/ha) applied at 8, 12 and 16-day intervals, using randomized block treatments and four replicates. A self-propelled sprayer with 16 bars, XR11001VS nozzles and 150 L/ha volume was employed. Leaflet rust severity in R5.4 stage and grain yield were evaluated. Data were subjected to analysis of variance, and means were compared according to Tukey’s test. At eight-day intervals (six sprayings), control ranged from 75% to 93%; at 12-day intervals (four sprayings), it ranged from 35 to 63%, and at 16-day intervals (three sprayings), control ranged from 15 to 29% according to the sprayed levels. The longer the interval between applications, the lower the response of the used level for rust control and soybean grain yield. Chlorothalonil showed fungitoxicity to integrate a program of anti-resistance strategies to control soybean rust.
Aborto e luta por direitos humanos na ALERJ: religiosos e feministas em disputa
Authors: Luna Naara , Owsiany Laryssa
Published: October 2019

Resumo: Este artigo procura analisar o debate sobre aborto na Assembleia Legislativa do Estado do Rio de Janeiro entre os anos de 2015 e 2017, considerando a luta por direitos humanos e a presença de agentes religiosos e laicos nessas disputas. Trata-se de pesquisa qualitativa com análise documental dos discursos e proposições legislativas no período sob análise, localizados por meio de busca por palavras-chave no site da ALERJ. Será analisado o tipo de argumentação usada. Observa-se o protagonismo de atores religiosos.
Intercambialidade de produtos biológicos no Sistema Único de Saúde (SUS): principais desafios regulatórios
Authors: Ferreira Neto Paula Teixeira Pinto , Nunes Patrícia Helena Castro , Vargas Marco Antonio
Published: October 2019

Resumo: Produtos biológicos revolucionaram a terapêutica mundial. O alto custo desses medicamentos, no entanto, ameaça a sustentabilidade dos sistemas de saúde. O desenvolvimento de cópias é tido como uma alternativa econômica, mas devido à complexidade desses produtos, muitos conceitos utilizados para os medicamentos genéricos não se aplicam. A intercambialidade entre produtos biológicos representa um desafio regulatório a ser superado. Este ensaio discute os principais desafios regulatórios relacionados ao estabelecimento de critérios para intercambialidade entre produtos biológicos novos e suas cópias no âmbito do Sistema Único de Saúde (SUS), considerando as diretrizes adotadas pelas principais agências reguladoras de medicamentos do mundo sobre a intercambialidade e o arcabouço regulatório vigente no Brasil para esta questão. Preocupações relacionadas à intercambialidade de produtos biológicos incluem substituição automática, nomenclatura, farmacovigilância, imunogenicidade e extrapolação das indicações terapêuticas e dos dados clínicos de produtos biológicos novos para suas cópias. Embora o sucesso clínico e os benefícios econômicos da alternância entre alguns produtos biológicos novos e seus biossimilares já tenham sido observados, a heterogeneidade das barreiras regulatórias para aprovação das cópias de produtos biológicos entre diferentes países deve ser considerada para a regulamentação da intercambialidade de produtos biológicos no Brasil.
Analysis of the relationship between company characteristics and key audit matters disclosed
Authors: Ferreira Catarina , Morais Ana Isabel
Published: October 2019

ABSTRACT The general objective of this study is to analyze whether the particularities of audited companies influence the volume of key audit matters (KAMs). Its specific objectives are to identify the number of KAMs disclosed by Brazilian companies and analyze the main factors associated with their disclosure. The paper aims to contribute to an area of investigation still lacking in studies that analyze the factors affecting KAM disclosure, which makes audit reports more individualized. The study contributes to understanding the main auditing issues in Brazilian companies that auditors consider relevant, by providing evidence on factors associated with their disclosure. This research is relevant for agencies that issue auditing standards and for financial information users. For issuers of auditing standards, the study is relevant because it identifies the factors associated with KAM disclosure, enabling it to be confirmed that the new audit report model has contributed to its destandardization. For financial information users, the study demonstrates that KAM disclosure varies from company to company, thus contributing to greater transparency of the audit report. Data were collected from the Audit Reports and Consolidated Financial Statements of the 447 Brazilian companies listed on the São Paulo Securities, Commodities, and Futures Exchange (BM&FBovespa), on December 31st of 2016, and an ordinary least squares (OLS) regression was applied to the defined model. The results show a positive relationship between the number of KAMs disclosed and both the auditor being a Big 4 and the complexity of the audited company. The auditor’s fees and auditor’s opinion being modified show a negative relationship with the number of KAMs. The article is relevant for companies, auditors, and regulatory and supervisory bodies as it identifies company characteristics that influence KAM disclosure and are determinants for the non-standardization of the auditor’s report.
TEACHING-SERVICE INTEGRATION IN THE TRAINING OF HEALTH RESIDENTS: THE TEACHER’S PERSPECTIVE
Authors: Mello Amanda de Lemos , Terra Marlene Gomes , Nietsche Elisabeta Albertina , Backes Vânia Marli Schubert , Kocourek Sheila , Arnemann Cristiane Trivisiol
Published: October 2019

ABSTRACT Objective: to understand the development of teaching-service integration actions in the training of residents, from the perspective of teachers linked to a Multiprofessional Health Residency Program. Method: qualitative research, of the exploratory and descriptive type, carried out between March and June 2015, with 13 teachers from a semi-structured interview and a systematic observation. Data was organized and analyzed through the operational proposal of thematic analysis. Results: the construction of new spaces for the development of the teaching-service integration in the Multiprofessional Residency in Health is evident, coming from the effective relationship between the university and the health services, besides the insertion of the professionals who were resident in those services, besides challenges that permeate this proposal. Conclusion: the Multiprofessional Health Residency, as a training strategy, tends to broaden health practices by providing residents with the opportunity to participate in a collaborative, dynamic and active process in their professional training. However, the teaching-service integration requires a continuous reflection of the role of each one, in order to stimulate co-responsibility in the pedagogical process according to public health policies and local reality.
CONSTRUCTION OF AN EDUCATIONAL VIDEO ON POSTOPERATIVE CARE FOR CHEILOPLASTY AND PALATOPLASTY
Authors: Razera Ana Paula Ribeiro , Trettene Armando dos Santos , Mondini Cleide Carolina da Silva Demoro , Cintra Flavia Maria Ravagnani Neves , Razera Fernanda Pátaro Marsola , Tabaquim Maria de Lourdes Merighi
Published: October 2019

ABSTRACT Objective: to describe the process for building up an educational video on the postoperative cares for primary cheiloplasty and palatoplasty surgeries. Method: a five-step technology elaborated development study (analysis and planning, modeling, implementation, evaluation and distribution) conducted in a public institution specialized in treating cleft lip and palate. Results: the evaluation was carried out by six judges regarding content criticism and criteria of familiarity, plausibility and linguistic clarity. Concordance percentage was 98%, which obtained approval and consent from most of the judges participating in the study. The feature adopted after the judges’ analysis was qualified as a facilitator of the information needed to train caregivers' skills in the specific postoperative condition, and an additional in procedures related to basic health care in the hospital system. The video was completed with 11 minutes and 50 seconds. Conclusion: the educational video proved to be efficient in its constitution and applicability for preparing parents and other children caregivers who live with the need to learn about the postoperative care of cheiloplasty and palatoplasty surgeries.
A igreja Matriz de Santa Luzia e seus retábulos
Authors: PEDROSA AZIZ JOSÉ DE OLIVEIRA
Published: October 2019

RESUMO A igreja Matriz de Santa Luzia, localizada na cidade mineira homônima, abriga em seu interior conjunto de retábulos que ainda não foram devidamente analisados pela historiografia da arte, apesar de se tratar de peças de significativa importância para o contexto da talha setecentista luso-brasileira. Diante das sombras que repousam sobre o tema, este artigo tem como orientação elementar o estudo de três retábulos do referido templo, em prol de conhecer os aspectos históricos e estilísticos que nortearam sua produção, bem como suas prováveis relações com outros exemplares congêneres encontrados em Minas Gerais.
Social Representations of Haitian Immigrants about Labor in Brazil
Authors: Anjos Nara Angela dos , Polli Gislei Mocelin
Published: October 2019

Abstract The growth in the number of immigrants in Brazil has stimulated reflections on how these people represent and signify aspects of the new context in which they are situated. This study aimed to trace social representations of Haitian immigrants about work in Brazil. Fifteen Haitians from a city in southern Brazil participated in the study. We used a questionnaire and an interview that addressed what they thought of work in Brazil before they migrated, at the time of the interview, and what they imagined for the future. The answers of the questionnaire were submitted to a statistical program and analyzed descriptively. The content of the interviews was treated by the IRaMuTeQ program. The shared thought about work in Brazil changed over time. Before they migrated, they imagined many opportunities and high salaries. In Brazil they faced difficulties with heavy work and low salaries. They hope that the future will be better, with a desired job and the family present. This study generated information that may support public policies that facilitate the adaptation to the Brazilian culture and labor market.
Preparation of the discharge of relatives of children using antibiotics: contributions of nursing
Authors: Alves Luciana Lima , Silva Liliane Faria da , Cursino Emília Gallindo , Góes Fernanda Garcia Bezerra , Silva e Sousa Amanda Danielle Resende , Moraes Juliana Rezende Montenegro Medeiros de
Published: October 2019

Abstract Objective: To describe the discharge preparation for relatives of hospitalized children for continuing antibiotic therapy at home, from the nurse perspective. Method: A descriptive and qualitative research, performed in the ward of a pediatric hospital in Rio de Janeiro. It was attended by fifteen nurses through semi-structured interviews, between April and May 2018, and data was submitted to Thematic Analysis. Results: The following thematic units emerged: Preparing the relatives for the discharge as a punctual moment; Professionals involved in the preparation of the discharge for relatives; Educational strategies in preparing the relatives for the discharge; and Communication among professionals in preparing the relatives for the discharge. Conclusion and implications for practice: There is a need to systematize the discharge process of the child that leaves the hospital to finish their therapeutic scheme with antibiotics at home, thereby avoiding inappropriate use and therapeutic errors.
Health of the LGBTI+ Population in Primary Health Care and the Insertion of Nursing
Authors: Santos Juliana Spinula dos , Silva Rodrigo Nogueira da , Ferreira Márcia de Assunção
Published: October 2019

Abstract Objective: To reflect on the approaches to the health of the LGBTI+ population, Primary Health Care and Nursing in the care of this population. Method: The reflection is based on a brief characterization of the LGBTI+ population and their health, an analysis of the nurses' work in Primary Health Care (PHC), and a debate about particularities of the nursing care for the LGBTI+ population in the PHC. Results: The LGBTI+ population is composed of many populations defined by the diversity of gender identity and expression, sexual orientation, and biological sex. In Family Health teams, nurses must know the main demands of this population. The institutional reorientation of PHC imposes new challenges to the enjoyment of the right to health of the LGBTI+ population. Conclusion and implications for practice: Although the National LGBT Health Policy is seven years old, studies are still scarce, foremost in Nursing. Considering that the LGBTI+ population is also under the Nursing responsibility in the PHC, it is up to this professional category to provide integral assistance with a view to minimizing the inequalities suffered by this population.
Experiência laboral e inclusão social de indivíduos com esquizofrenia
Authors: Martini Larissa Campagna , Lussi Isabela Aparecida de Oliveira , Magalhães Lilian , Santos Fernanda Vieira , Pimentel Fernanda de Almeida , Petreche Maria Beatriz , Fonseca Ana Olivia , Attux Cecilia , Bressan Rodrigo Affonseca
Published: October 2019

Resumo Objetivos: compreender os aspectos positivos e negativos das experiências relacionadas ao trabalho relatadas por indivíduos com esquizofrenia, usuários de um ambulatório de especialidades envolvido em um programa de inclusão laboral. Métodos: estudo com abordagem qualitativa e observacional. Onze participantes responderam a uma pergunta norteadora aberta: “o que você percebe como aspectos positivos e negativos na sua experiência de trabalho?”. Os dados foram categorizados por meio de análise temática. Resultados: foram identificadas 4 categorias: sobrecarga e falta de informação/orientação no trabalho; a importância da remuneração; assumindo responsabilidades, esperança e superação; a vivência da doença, o cuidado com a saúde e o trabalho. O estudo mostrou a importância de buscar estratégias eficazes de inclusão laboral para indivíduos com esquizofrenia, que considerem as especificidades da doença e os fatores estressantes relacionados ao trabalho como potenciais desencadeadores de sofrimento físico e emocional. Conclusão: é fundamental investir em ações que possibilitem efetiva inclusão laboral de pessoas com esquizofrenia. Tais medidas devem contemplar os portadores de esquizofrenia, suas famílias, as empresas e os profissionais dos serviços de saúde mental. As especificidades da doença, as necessidades, os interesses e o potencial da pessoa devem ser considerados.
LYMPHOCYTE COUNT AND PLATELET VOLUME PREDICTS POSTOPERATIVE COMPLICATIONS IN ESOPHAGECTOMY FOR CANCER: A COHORT STUDY
Authors: TUSTUMI Francisco , TAKEDA Flávio Roberto , BRANDÃO Antonio Adolfo Guerra Soares , SALLUM Rubens Antonio Aissar , RIBEIRO JUNIOR Ulysses , CECCONELLO Ivan
Published: October 2019

ABSTRACT BACKGROUND: Biomarkers from routine complete blood count are known predictive factors of long-term outcomes in cancer patients. The value of these biomarkers in the setting of trimodal therapy for esophageal cancer in predicting early postoperative outcomes is not studied. OBJECTIVE: The present study evaluated the value of cellular blood components changes during neoadjuvant chemoradiotherapy followed by curative intent esophagectomy for cancer in predicting postoperative mortality and morbidity. METHODS: A cohort of 149 consecutive patients that underwent chemoradiotherapy using platinum- and taxane-based regimens followed by esophagectomy was analyzed. Cellular components of blood collected before neoadjuvant therapy (period A) and before surgery (period B) were assessed for postoperative mortality and complications. Univariate and multivariate Cox regression models were applied to evaluate the independent prognostic significance of blood count variables. RESULTS: Postoperative morbidity was present in 46% of the patients. On multiple regression analysis platelet volume (B) (OR: 1.53; 95% CI: 1.2-2.33) was an independent predictor of general complications. Severe postoperative surgical complications were present in 17% of the patients. On multiple regression analysis, lymphocyte decrease between B-A periods (OR: 0.992; 95% CI: 0.990-0.997) was related to higher risk for severe complications. Cervical anastomotic leakage was present in 25.6% of the patients. On univariate analysis eosinophil count in A and B periods was related to cervical anastomotic leakage. For this outcome, multivariate joint model could not identify independent risk variables of cellular components of blood. The 30-day mortality rate was 7.4%. On univariate analysis, platelet count in period B was associated to higher risk for mortality. The multivariate joint model could not accurately predict mortality due to the few number of patients in the mortality group. CONCLUSION: This is the first study to assess the relationship between peripheral blood count variables changes during neoadjuvant chemoradiotherapy using a platinum- and taxane-based regimen followed by curative intent esophagectomy for cancer in predicting postoperative complications. The platelet volume prior to surgery is related to postoperative complications and the lymphocyte count change prior to surgery predicts severe postoperative complications in the setting of trimodal therapy for esophageal cancer.
Physiological parameters of cowpea treated with CaO-based particle film and subjected to water restriction
Authors: Oliveira Júnior Luiz Fernando Ganassali de , Santos Patrícia Lima de Souza , Lima Roberta Samara Nunes de , Silveira Maria Priscilla Celestino , Fagundes Jailson Lara , Carnelossi Marcelo Augusto Gutierrez , Reis Fabrício de Oliveira
Published: October 2019

Abstract: The objective of this work was to evaluate the effects of CaO-based particle film on the physiological parameters of cowpea (Vigna unguiculata) subjected to water restriction. Plants were subjected to two levels of soil moisture and three concentrations of the film, as follows: control, without film + 100% crop evapotranspiration (ETc); without film + 50% ETc; 5% CaO + 50% ETc; 10% CaO + 50% ETc; 5% CaO + 100% ETc; and 10% CaO + 100% ETc. Plants treated with 50% ETc remained stable with the application of 10% CaO particle film and showed high photosynthetic assimilation of CO2 (32 μmol m-2 s-1), moderate transpiration (5.6 mmol m-2 s-1), maintenance of chlorophyll content, and greater intrinsic water-use efficiency (IWUE, 226.65 μmol mol-1) and instantaneous water-use efficiency (6.06 μmol mmol-1) than plants of the other treatments. Control plants and plants at 5% CaO + 50% ETc showed, respectively, photosynthetic assimilation of CO2 at 15.34 and 15.94 μmol m-2 s-1, transpiration at 3.51 and 3.45 mmol m-2 s-1, and IWUE at 177.7 and 198.9 μmol mol-1. The CaO-based particle film is effective in protecting bean plants subjected to water restriction.
Tetrazolium test for Pinus taeda: preparation, staining, and seed viability classes
Authors: Santos Felipe Serrato dos , Vieira Elisa Serra Negra , Panobianco Maristela
Published: October 2019

Abstract: The objective of this work was to evaluate preparation and staining methods used in the tetrazolium test for Pinus taeda seeds, with the definition of viability classes. The procedures carried out were those described in the rules for seed testing in Brazil and Association of Official Seed Analysts, as well as an alternative method for the tetrazolium test. For each procedure, different combinations of types of seed cuts, concentrations of tetrazolium salt, and exposure periods were used. The test conducted with the alternative procedure (longitudinal cut adjacent to the embryo and staining of only the half with the embryo) is the most practical. The obtained results allowed classifying seeds into two different viability classes (viable and nonviable), and 0.2% tetrazolium salt for 4 hours is the most effective combination.
Narrativas biográficas de inmigrantes: construcción y transmisión intergeneracional de experiencias escolares
Authors: Leo Pablo Francisco Di , González Mariana Alejandra
Published: October 2019

Resumen En este artículo presentamos los principales hallazgos de una investigación cuyo objetivo general es analizar las representaciones en torno a la escolaridad en los relatos biográficos de personas migrantes que residen en barrios populares, indagando sobre las vinculaciones entre sus propias trayectorias educativas y las de las niñas y los niños que tienen a cargo. Para la construcción de datos se desarrolló una estrategia metodológica cualitativa, realizando entrevistas biográficas semiestructuradas a adultos migrantes, que residen en un barrio vulnerabilizado de la Ciudad Autónoma de Buenos Aires, Argentina, y que tienen niñas y niños a cargo cursando la escuela primaria. Para el análisis de los datos se siguieron los lineamientos de la teoría fundamentada. Aquí se desarrollan los principales resultados del estudio, organizados en torno a tres dimensiones: experiencias educativas de los adultos; escolaridades de los niños; transmisión intergeneracional de las experiencias. El artículo concluye que las personas migrantes de sectores populares construyen y transmiten intergeneracionalmente sus experiencias escolares atravesando diversas pruebas sociales y discontinuidades identitarias, en las que van mutando los sentidos y las articulaciones de las lógicas de la acción: integración, estrategia y subjetivación. Se observa la centralidad que ocupa la trayectoria educativa como un elemento primordial de sostén del proyecto migratorio familiar, consolidado como un esfuerzo común.
Dimensionamento de pessoal no centro de material e esterilização de um hospital universitário
Authors: Martins Junior Franco , Antunes Arthur Velloso
Published: October 2019

RESUMO Objetivo Aplicar os parâmetros de tempo padrão das atividades de enfermagem propostos pela Resolução COFEN n.º 543/2017 para dimensionar o quantitativo de técnicos de enfermagem no centro de material e esterilização de um hospital universitário e comparar o quadro projetado com o existente no setor. Método Pesquisa exploratória e descritiva, com a coleta de dados realizada nas folhas de controle de esterilização e observação direta das etapas do processo de trabalho nas diferentes áreas do setor. Resultados Apenas uma das 15 atividades descritas não era realizada no setor; as mais realizadas, que apresentaram maior carga de trabalho e requeriam maior número de pessoal foram a recepção de materiais contaminados e a organização e distribuição do material esterilizado; as áreas que requeriam maior quantitativo de funcionários foram o preparo de materiais e o expurgo. Não foi observada diferença entre o número de pessoal requerido nos diferentes turnos de trabalho, e o quantitativo de pessoal calculado foi semelhante ao existente ao resultado do dimensionamento realizado utilizando os chamados sítios funcionais. Conclusão As propostas analisadas neste estudo podem ser utilizadas para o cálculo de pessoal no setor estudado e em outras instituições.
A method for the permeabilization of live Drosophila melanogaster larvae to small molecules and cryoprotectants v1
Authors: Murray Alex , Palmer Daniel , Bennett Daimark , Dwarampudi Venkata
Published: October 2019

The larvae of Drosophila melanogaster is a model organism used to study the muscular and nervous systems. Drosophila larvae are surrounded by a waxy cuticle that prevents permeation by most substances. Here we develop a method to remove this layer, rendering the larvae permeable to small molecules. Permeability is assessed using fluorescein diacetate dye uptake, and mortality upon exposure to toxic levels of ethylene glycol and DMSO. Potential uses for this method include drug delivery, toxicity assays, cryopreservation, staining, and fixation.
Therapeutic Applications of Ethanol: A Review
Authors: Le Daré Brendan , Gicquel Thomas
Published: October 2019

Purpose: To review knowledge on therapeutic uses of ethanol and the latter’s effectiveness and safety profiles in a range of indications. Methods: MEDLINE and PubMed databases were searched for relevant peer-reviewed papers published in English between 1888 and 2018 using the following search terms: ethanol, therapeutic, alcohol withdrawal syndrome, antiseptic, antidote, methanol, ethylene glycol, neurolysis, embolization, cyst, sclerosing agent, sclerotherapy, arteriovenous malformations, ablating agent. Studies providing information about association between alcohol and therapeutic indications, or mechanic explanation for the association were included for review. Results: According to the World Health Organization, approximately three millions deaths worldwide are attributable to alcohol consumption each year. However, the low-to-moderate consumption of ethanol has a number of beneficial effects (mainly on cardiovascular mortality and diabetes). Hence, ethanol has an unusual spectrum of effects that seems interesting for therapeutic purposes. Ethanol’s risk-benefit ratio appears to be positive in some therapeutic indications such as antidote to methanol or ethylene glycol poisoning, neurolysis, alcohol withdrawal syndrome, or antiseptic. Conclusion: With the development of interventional radio technologies, and thus extremely precise access to anatomical structures, alcohol has been given new indications - particularly as an embolization, sclerosing or ablation agent. Moreover, constant progress in our knowledge of ethanol’s pharmacodynamics might highlight other therapeutic indications for this compound in the future. Ethanol’s low cost and wide availability make it a valuable therapeutic agent, compared with other reference treatments. Furthermore, ethanol has a long track record of safety and effectiveness in the indications mentioned above.