bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyzing the concept of sexual self-care in preschool children: A qualitative study
Authors: Rahimi Khalifeh Kandi Zahra , Ebadi Fard Azar Farbod , Farahani Farideh Khalajabadi , Azadi Nammamali , Mansourian Morteza
Published: April 2023

BACKGROUND:

Child sexual abuse is a global concern for families and societies. Therefore, child protection from sexual harassment is of particular importance. The present study aimed to investigate the concept of sexual self-care in children.

MATERIALS AND METHODS:

The present research is a qualitative study conducted with a content analysis approach. The study participants include 39 child sex education specialists, parents of children aged 4–7 years, adolescents who were sexually abused in childhood, and those with no experience of sexual abuse in childhood. The participants were selected through purposive sampling method. Different people's interpretations of the concept of sexual self-care in children were explored using semi-structured and face-to-face interviews, which continued until the saturation of concepts. Data were analyzed using the Graneheim and Lundman method. Guba and Lincoln's criteria were used to strengthen the validity and transferability of the data.

RESULTS:

Sexual self-care in children was identified from participants' viewpoints in the study. This self-care includes three main components and six subcomponents of (1) knowledge about privacy, risk situation, and trustworthy people, (2) attitude and perception of risk, and (3) behavioral skills in self-protection (i.e., post-injury reaction).

CONCLUSION:

Further injuries can be prevented by improving the level of awareness, forming the right attitude, and strengthening children's behavioral skills toward sexual self-care. Such issues, which are representatives of privacy, risk situations, and self-protection ability, can improve children's sexual self-care skills.
Coexistence of Periodontal Pathogens and Helicobacter pylori in the Oral Cavity of a Healthy Cohort
Authors: Bennett Josefina , Carrasco Patricio , Solis Francisca , Morroni Rainiero , Gallardo Jorge , Silva Carolina María Inostroza
Published: April 2023

Background:

The oral cavity has optimal conditions to act as a reservoir of microorganisms.

Aims and Objectives:

This research corresponds to a descriptive study, which aims to study the presence or absence of periodontopathogens andHelicobacter pyloriin oral swab samples from healthy Chilean women between 18 and 26 years old.

Materials and Methods:

Fifty-four oral samples were recruited and then cultured on 5% blood agar plates for the semiquantitative macroscopic microbiological analysis. Of the 54, only 38 showed regular to abundant bacterial growth. Of these 38 samples, 21 were randomly selected and analyzed by conventional polymerase chain reaction (PCR) to detect periodontopathogens (Porphyromonas gingivalis, Treponema denticola, andTannerella forsythia) and Helicobacter pylori.

Results:

71% of the samples studied were negative for this group of bacteria, while 29% were positive for at least one of the microorganisms studied. Of this group, six samples were positive forHelicobacter pylori, one forTreponema denticola, and three forTannerella forsythia. These last two microorganisms were presented together withHelicobacter pylori.

Conclusion:

The buccal swab of the healthy cohort was a matrix that allowed bacterial molecular analysis; however, due to the small sample size, no correlations were found between them.
Comparison between Subjective and Colorimetric Probe Technique in Grading Interdental Embrasure Spaces in Esthetic Zone
Authors: Alampur Vishal , Gooty Jagadish Reddy , Guntakandla Vikram Reddy , Rajababu Palaparthi
Published: April 2023

Background:

An effective nonsurgical and surgical periodontal treatment cannot be accomplished by brushing alone as it does not detach the plaque interdentally. Interdental cleaning aids can remove this interdental plaque. This optimizes the plaque control. Selecting the right size of interdental brush fills the entire interdental space thereby cleaning all the areas of the embrasure.

Aim:

The aim of the study was to assess the grading of gingival embrasure by periodontists with subjective technique and calibrated interdental probe.

Subjects and Methods:

Ten healthy patients were selected for the study. Gingival embrasures of patients were assessed with discretion by six periodontists. Later, every periodontist was educated about the use of calibrated probes. After a specific time-lapse, all the periodontists have examined the same patients again with the calibrated interdental probe. The embrasures in the patients were examined from left to right in maxillary and mandibular single-rooted and bicuspid teeth.

Statistical Analysis:

The assessment of scores between calibrated and arbitrary techniques by a single doctor for each gingival embrasure in all the patients was calculated by the Wilcoxon matched pair test. Comparison between doctors with the mean error was calculated by the Kruskal–Wallis ANOVA.

Results:

Significant results were observed in grading gingival embrasures by individual periodontists for every tooth between calibrated and arbitrary techniques.

Conclusions:

Based on morphology and location of teeth the gingival embrasure space differs. Choosing an interdental aid subjectively, probably will not give an appropriate cleaning viability. To accomplish a legitimate cleaning viability, an appropriate size interdental brush ought to be chosen for a specific embrasure. Utilizing a calibrated interdental probe helps the clinician choose an appropriate interdental brush for a specific embrasure space.
Tissue eosinophilia and computed tomography features in paediatric chronic rhinosinusitis with nasal polyps requiring revision surgery
Authors: Wu P-W , Chiu C-H , Huang Y-L , Fan Y-H , Lee T-J , Huang C-C , Chang P-H , Huang C-C
Published: April 2023

Background: Endoscopic sinus surgery (ESS) is an effective and safe treatment modality for medically recalcitrant chronic rhinosinusitis (CRS) in the paediatric population, especially in older children or those with nasal polyposis (CRSwNP). We aimed to elucidate the inflammatory pattern and clinical characteristics of CRSwNP related to revision surgery after ESS in a paediatric population. Methods: We retrospectively enrolled 146 patients with bilateral CRSwNP. Twenty-two patients had recurrent nasal polyps that required revision surgery. The clinical characteristics, computed tomography (CT) features, tissue eosinophil count, and immunoactivity of signature cytokines in the two groups were analysed. Results: Tissue eosinophil infiltration and immunoreactivity of eosinophilic cationic protein and IL-5 in the sinus mucosa were higher in patients that required revision surgery. The revision surgery group was significantly younger and had positive aeroallergen test results, higher total Lund-Mackay scores, and ethmoid/maxillary sinus ratio on CT images than those without revision surgery. A nomogram was developed to predict the probability of the requirement of revision surgery according to the logistic regression analysis results. Conclusions: We developed a nomogram model using clinical characteristics, tissue eosinophilia, and CT features for the preoperative identification of patients vulnerable to revision surgery in paediatric CRSwNP. This could help clinicians predict the probability of recurrence and perform intensive postoperative adjunct therapy and follow-up.
Мультипликаторы для конструкции Кальдерона
Authors: Berezhnoi Evgenii Ivanovich
Published: April 2023

На основе нового подхода для конструкции Кальдерона $X_0^{\theta} X_1^{1-\theta}$, построенной по идеальным пространствам $X_0$, $X_1$ и параметру $\theta \in [0,1]$, приведено несколько окончательных результатов, касающихся описания пространства мультипликаторов. В частности, показано, что для идеальных пространств $X_0, X_1$, обладающих свойством Фату, верно равенство $M(X_0^{\theta_0} X_1^{1-\theta_0}\to X_0^{\theta_1} X_1^{1-\theta_1}) = M(X_1^{\theta_1 - \theta_0} \to X_0^{\theta_1 -\theta_0})$, $0 <\theta_0 <\theta_1 <1$. Отсутствие ограничений на идеальные пространства $X_0$, $X_1$ позволяет применить полученные результаты для широкого класса идеальных пространств.
Сюръективность этального вырезания для гомотопически инвариантных предпучков с оснащенными трансферами
Authors: Druzhinin Andrei Eduardovich , Panin Ivan Alexandrovich
Published: April 2023

В. Воеводский в фундаментальных заметках "Notes on framed correspondences" определил категории оснащенных соответствий, оснащенных предпучков и оснащенных пучков. Отправляясь от этих заметок, Г. Гаркуша и И. Панин предъявили совершенно новый способ построения стабильной мотивной гомотопической категории $\mathrm {SH}(k)$. Их новое описание классической категории $\mathrm {SH}(k)$ использует исключительно локальные эквивалентности при условии, что основное поле $k$ бесконечно, совершенно и его характеристика не равна $2$. Основная цель работы - распространить фундаментальный результат Гаркуши и Панина о предпучках с оснащенными трансферами на все бесконечные совершенные поля (включая характеристику $2$). Как следствие оказывается, что локальная конструкция категории $\mathrm {SH}(k)$ работает автоматически без ограничений на характеристику основного поля. Центральная часть настоящей статьи - доказательство гомотопической инвариантности пучка Нисневича $\mathcal F_{\mathrm{Nis}}$, ассоциированного с гомотопически инвариантным раддитивным квазистабильным предпучком Нисневича $\mathcal F$. Затем дословное воспроизведение аргументов Гаркуши и Панина позволяет установить строгую гомотопическую инвариантность пучка $\mathcal F_{\mathrm{Nis}}$.
Свойство Жордана для группы Кремоны над конечным полем
Authors: Prokhorov Yuri Gennadievich , Shramov Constantin Aleksandrovich
Published: April 2023

Доказано, что группа Кремоны ранга $2$ над конечным полем является жордановой, и получена оценка сверху ее константы Жордана. Эта оценка точна, если количество элементов в поле не равно $2$, $4$ или $8$.
Обнуление весов на языке $t$-структур
Authors: Bondarko Mikhail Vladimirovich , Vostokov Sergei Vladimirovich
Published: April 2023

Работа посвящена морфизмам, обнуляющим веса в некоторых диапазонах (это понятие было введено первым автором), и объектам, лишенным этих весов (таковые фактически были определены Й. Вильдесхаусом), в триангулированной категории, снабженной весовой структурой $w$. Приводится несколько новых критериев того, что морфизмы и объекты принадлежат указанным классам. В некоторых критериях используются виртуальные $t$-срезки и $t$-структура, смежная с $w$. При условии существования последней доказывается, что морфизм обнуляет веса $m,…,n$ тогда и только тогда, когда он пропускается через объект, лишенный этих весов; кроме того, строятся новые семейства теорий кручения, а также проективных и инъективных классов. В результате получаются некоторые "слабо функториальные разложения" спектров (в стабильной гомотопической категории $\mathrm {SH}$) и новое описание тех морфизмов, которые обнуляют сингулярные когомологии $H_{\mathrm{sing}}^0(-,\Gamma )$ с коэффициентами в произвольной абелевой группе $\Gamma $.
Теория Шура-Сато для квазиэллиптических колец
Authors: Zheglov Alexander Borisovich
Published: April 2023

Понятие квазиэллиптических колец появилось в результате попытки классификации широкого класса коммутативных колец операторов, встречающихся в теории интегрируемых систем, таких как кольца коммутирующих дифференциальных, разностных и дифференциально-разностных операторов. Они содержатся в некотором некоммутативном "универсальном" кольце - чисто алгебраическом аналоге кольца псевдодифференциальных операторов на многообразии и допускают (при достаточно слабых ограничениях) удобное алгебро-геометрическое описание. Важной алгебраической частью этого описания является теория Шура-Сато - обобщение хорошо известной теории для обыкновенных дифференциальных операторов. Некоторые части этой теории были изложены ранее в серии статей, в основном для размерности $2$. В настоящей работе эта теория развивается для произвольной размерности. Она применяется для доказательства двух теорем классификации квазиэллиптических колец в терминах некоторых пар подпространств (пар Шура). Они необходимы для упомянутого выше алгебро-геометрического описания квазиэллиптических колец. Теория эффективна и имеет несколько других приложений, среди которых новое доказательство формулы обращения Абьянкара.
Устойчивость стационарного решения с двухмасштабным внутренним переходным слоем системы уравнений типа активатор-ингибитор
Authors: Levashova Natalia Timurovna , Samsonov Dmitry Sergeevich
Published: April 2023

Проведено исследование краевых задач для систем обыкновенных уравнений второго порядка с условиями квазимонотонности, характерными для задач типа активатор-ингибитор, и с решениями, содержащими области с большими градиентами. Указаны достаточные условия существования устойчивого стационарного решения. С помощью асимптотического метода дифференциальных неравенств проведено доказательство теорем существования и устойчивости.
О неустойчивых контрастных структурах в одномерных задачах реакция-диффузия-адвекция с разрывными источниками
Authors: Nefedov Nikolai Nikolaevich , Orlov Andrei Olegovich
Published: April 2023

Развивается новый метод исследования неустойчивых контрастных структур - решений с внутренним переходным слоем, основанный на построении достаточно точных неупорядоченных верхних и нижних решений и применении следствия из теоремы Крейна-Рутмана. Сформулированы условия существования неустойчивых по Ляпунову одномерных контрастных структур типа ступеньки как стационарных решений сингулярно возмущенных параболических уравнений реакция-диффузия с разрывной правой частью. Показано, что полученные результаты можно распространить на другие сингулярно возмущенные одномерные задачи реакция-диффузия-адвекция с разрывными нелинейностями.
Вариационная постановка задачи о колебаниях балки с подвижной подпружиненной опорой
Authors: Litvinov Vladislav Lvovich
Published: April 2023

Поставлена задача о колебаниях балки с подвижной подпружиненной опорой, несущей присоединенную массу. Когда опора не является абсолютно жесткой, через подвижную границу происходит энергетический обмен. В связи с этим возникает сложность в задании граничных условий. Для постановки задачи использован вариационный принцип Гамильтона. При этом учитываются вязкоупругие свойства материала балки. Поставленная задача включает в себя дифференциальное уравнение колебаний, начальные условия для изогнутой оси балки и присоединенной массы, а также граничные условия. Условия на подвижной границе записываются как соотношения для значений функции и ее производных слева и справа от границы.
Analysis of Growth Inhibition for Microcystis aeruginosa with Periodic Ultrasonic Irradiations
Authors: Kang Eun Byeol , Joo Jin Chul , Jang So Ye , Go Hyeon Woo , Park Jungsu , Lee Dong-Ho , Ahn Chang Hyuk
Published: April 2023

Objectives : To confirm both efficiency and sustainability of algal growth inhibition, various laboratory-scale experiments were conducted and the growth inhibitory effect of Microcystis aeruginosa (M. aeruginosa) was investigated through ultrasonic re-irradiation during the regrowth period after the first ultrasound irradiation.Methods : Experiments with different times of irradiation [i.e., control group A (0 hr), experimental group B (2 hr) applied with only the first ultrasound irradiation, and experimental group C (0.5 hr), D (1 hr), and E (1.5 hr) applied with both first and second irradiations] were performed.Results and Discussion : As a result of both Chlorophyll-a (Chl-a) concentration and cell number of M. aeruginosa, the experimental group (B) with only first ultrasound irradiation (2 hr) displayed rapid regrowth of algae after initial decrease whereas the experimental group (C, D, and E) with both first ultrasound irradiation (2 hr) and second ultrasound irradiation (0.5 hr, 1 hr, and 1.5 hr) confirmed the delay of algae regrowth. Based on the specific growth rate constant (µ) and first order decay rate constant (k), algal growth from the experimental groups (C, D, E) with the secondary ultrasound irradiation was more significantly inhibited due to repetitive inactivation of algae growth. According to the SEM and TEM results, damages to algae cells were clearly observed under the influence of ultrasound, and both decrease in gas vesicles and rupture of cell membrane in M. aeruginosa were also monitored.Conclusion : Through this study, the algae growth inhibitory effect by ultrasonic irradiations was confirmed, and the re-irradiation of ultrasound contributed to the repetitive inactivation of algae growth, indicating that the second ultrasonic irradiation time required to inhibit algal regrowth can be reduced compared to the first irradiation. Therefore, periodic ultrasonic irradiation is required for long-term inhibition of algae growth in stagnant waters, but the appropriate frequency of ultrasonic irradiation may vary depending on the influence of various complex factors such as the size of the stagnant waters, the frequency of algal blooms, water temperature, light irradiation, nutrients, flow rate, etc. Finally, many field studies under various conditions are warranted to establish an optimized ultrasound irradiation protocol.
Evolución postmoderna de la acción motriz en la primera infancia, mirada desde la motricidad humana
Authors: Romero Cuestas Carlos Alberto , Campos Mavare Mercedes Moraima , Prado Pérez José Rafael
Published: April 2023

El presente ensayo científico, pretende un acercamiento teórico con una postura sobre los procesos de atención a la Primera Infancia (PI) en los Hogares Comunitarios de Bienestar Tradicionales (HCBT) en Colombia, fundamentado desde las Ciencias de la Motricidad Humana (CMH). Para ello realizamos un análisis desde la evolución primitiva de la humanidad, pasando a un dualismo en el cual el alma toma un protagonismo superior al cuerpo, superado por un análisis que, desde la complejidad de la CMH, permite entender la responsabilidad de la transdisciplinaridad, en el desarrollo integral de la PI, que hoy estamos recuperando de un largo periodo de aislamiento social promovido por la pandemia generada por el covid-19. Desde esta perspectiva exponemos que la acción motriz es anclaje para otros aprendizajes propios de la PI, desde los aspectos evolutivos que permitan entender el cómo las niñas y los niños aprenden.
Kandungan hidrogen cyanida (HCN), bahan kering, bahan organik umbi gadung (Dioscorea hispida dennst) menggunakan nira lontar dengan lama fermentasi yang berbeda
Authors: Wea Redempta , Betu Adrianus , Lema Abner T. , Koten Bernadete B. , Randu Melkianus D. S.
Published: April 2023

Good pig productivity depends on the feed given. however, feed ingredients for pigs generally compete with human needs, so the use of alternative feeds for gadung tubers with fermentation technology needs to be done. The aim of the research to examine Hydrogen cyanida (HCN) levels, dry matter( DM), and organic matter (OM) of gadung tubers using lontar sap with different fermentation times has been carried out at the Kupang State Agricultural Polytechnic from May - June 2022. The design used a Completely Randomized Design (CRD) consisting of 5 treatment and 5 repetitions; P0: gadung tuber (GU) + fermented palm sap (FPS) 0 days, P1: GU + FPS 3 days, P2: GU + FPS 6 days, P3: GU + FPS 9 days, and P4: GU + FPS 12 days. The results showed that the use of 10% PS with different fermentation times affected the HCN, DM, and OM content of gadung tubers. It was concluded that the HCN, DM, and OM content of gadung tubers were affected by fermentation using palm sap at different times and the best time was 3 days. It is recommended to carry out further research on the effect of feeding gadung tubers using palm sap with different fermentation times on the palatability and growth of pigs
Weed Identification in Agricultural Fields Using Machine Learning Techniques
Authors: Dhana Lakshmi Chepati , Satish Kumar Reddy Gajjala , Yaswanth Kumar Chukka , Mounika Chinta , Ravi Sekhar T
Published: April 2023

Weeds compete with crops for water, nutrients, and sunshine, which is one of the most detrimental restraints on crop development. They also constitute a danger to agricultural output. The loss of worldwide productivity due to weeds and pests is likely to rise over the next few years. Using herbicide spray particularly in the field where the weeds are present is an efficient technique to manage the problem. For the weed control system to be properly deployed, weeds must be accurately and precisely detected. Traditional weed management techniques, however, take a long time and a lot of human resources, and they may have an adverse effect on the environment. To overcome this a model called Automatic weed management, a potential remedy that makes use of deep learning and machine learning approaches, has emerged to deal with these issues. This method increases agricultural productivity and reduces herbicides.
Screening of Different Media and Heat Shock Treatment Regimens for Enhancing Sporulation in Bacillus licheniformis
Authors:   Department of Environmental Studies, North-Eastern Hill University, Shillong -793022, Meghalaya, India, Bidyaswori Devi Moirangthem , Dhar Rhea ,   Department of Environmental Studies, North-Eastern Hill University, Shillong -793022, Meghalaya, India, Bhattacharjee Atanu ,   Department of Biotechnology and Bioinformatics, North-Eastern Hill University, Shillong -793022, Meghalaya, India, Paul Dibyendu ,   Department of Environmental Studies, North-Eastern Hill University, Shillong -793022, Meghalaya, India
Published: April 2023

Bacillus licheniformis is a spore-producing bacteria. The present study aims to identify maximum sporulation in Bacillus licheniformis through induced heat shock conditions using different solidified media and broth media. Suspensions of Bacillus licheniformis spores were spread-plated on nutrient agar plates before and after heat shock treatments of 60°C, 80°C and 100°C for 30 minutes. The number of spores was determined by the dilution plate count method. The result indicates that the highest spore production for Bacillus licheniformis was observed when the spores were induced in AK (Arret and Kirshbaum) Agar for seven days under a heat shock treatment of 60℃ for 30 minutes. Whereas, in the case of Nutrient Broth media, the spore production was highest after four days at heat shock treatment of 80℃ for 30 minutes. This study will help find the optimal production of spores from Bacillus licheniformis, an industrially beneficial microorganism.
The Relationship Between Mother's Knowledge, Family Income, and Parenting Pattern with Stunting in Toddlers Aged 24-59 Months in the Working Area of Abepura Primary Health Center
Authors:   Sports Science Program, Faculty of Sports Science, Cenderawasih University, Papua, Indonesia, Mandosir Yohanis Manfred , Irab Piter ,   Health Department, Faculty of Public Health, Cenderawasih University, Jayapura, Papua, Indonesia, Mollet Genoveva ,   Health Department, Faculty of Public Health, Cenderawasih University, Jayapura, Papua, Indonesia, Irmanto Maxsi ,   Health Department, Faculty of Public Health, Cenderawasih University, Jayapura, Papua, Indonesia, Palela Devi ,   Health Department, Faculty of Public Health, Cenderawasih University, Jayapura, Papua, Indonesia, Renyaan Dorthea ,   Library Science Study Program, Faculty of Social and Political Science, Cenderawasih University, Jayapura, Papua, Indonesia, Rumaropen Nova Falentina ,   Health Department Faculty of Public Health Universitas Cenderawasih, Jayapura, Indonesia, Kristanto Budi ,   Department of Nutrition, Health Polytechnic of Jayapura, Papua, Indonesia, Sinaga Evi ,   Sports Science Program, Faculty of Sports Science, Cenderawasih University, Papua, Indonesia
Published: April 2023

Stunting is a disorder of growth and development of children due to chronic malnutrition and repeated infections, which are characterized by their length or height being below standard. The purpose of this study was to determine the relationship between mother's knowledge, family income and parenting style with stunting in toddlers aged 24-59 months in the working area of the Abepura Primary Health Center. This research is an observational study conducted using a cross-sectional study approach, carried out in October 2022. The number of samples was 71 respondents, namely all mothers who have toddlers in the working area of the Abepura Primary Health Center obtained through a purposive sampling technique. Collecting data on mother's knowledge, family income and parenting patterns used a questionnaire while determining stunting using the height for age indicator. Data analysis was carried out using the Chi Square test with an error rate of 95% using SPSS version 21. The results showed that there was a relationship between mother's knowledge and stunting, there was a relationship between family income and stunting and there was a relationship between parenting style and stunting.
Description of the Caries Pattern of Stunted Toddlers in Panduman Village, Jelbuk District, Jember Regency, East Java
Authors:   Pediatric Dentistry, Faculty of Dentistry, Jember University, Kalimantan Street No 37 Jember East Java Indonesia, Setyorini Dyah , Prihatiningrum Berlian ,   Pediatric Dentistry, Faculty of Dentistry, Jember University, Kalimantan Street No 37 Jember East Java Indonesia, Sulistiyani Sulistiyani ,   Pediatric Dentistry, Faculty of Dentistry, Jember University, Kalimantan Street No 37 Jember East Java Indonesia, Probosari Niken ,   Pediatric Dentistry, Faculty of Dentistry, Jember University, Kalimantan Street No 37 Jember East Java Indonesia, Budirahardjo Roedy ,   Pediatric Dentistry, Faculty of Dentistry, Jember University, Kalimantan Street No 37 Jember East Java Indonesia, Sukanto Sukanto ,   Pediatric Dentistry, Faculty of Dentistry, Jember University, Kalimantan Street No 37 Jember East Java Indonesia
Published: April 2023

Introduction: Stunting is a disruption of growth in toddlers, namely the height of toddlers is lower than the standard of age which is based on the body's long index compared to the age (PB / U) or height compared to the age (TB / U) with a zscore of less than -2 SD. Stunting can increase the risk of caries in the deciduous teeth because it cause atrophy in saliva and it also impairs the normal function of the salivary gland. The purpose of this study was to analyze the pattern of stunting children caries in Panduman Village, Jember, East Java. Methods: This study used an descriptive observasional with cross sectional approach. Samples were chosen using purposive sampling, amounted to 45 children. Result: The most commonly found caries were on occlusal surface of mandibular primary molar tooth with a profunda caries depth. It was found that 23 samples had caries on the occlusal surface of mandibulary molar teeth with 11 samples having profunda caries depth. Conclusion: The pattern of stunting children is most commonly found in mandibular primary molar on the occlusal surfaces with profunda caries depth.
Indonesian Regulations Related to State Losses in Persero State-Owned Enterprises Partly Owned by the State
Authors:   Faculty of Law, Universitas Diponegoro, Juliani Henny , Susila Wibawa Kadek Cahya ,   Faculty of Law, Universitas Diponegoro, Solechan Solechan ,   Faculty of Law, Universitas Diponegoro, Sonhaji Sonhaji ,   Faculty of Law, Universitas Diponegoro
Published: April 2023

Indonesian Regulations Related to State Losses in Persero State-Owned Enterprises Partly Owned by the State. Persero SOE as a form of SOE has capital in the form of share ownership which is wholly or at least 51% (fifty-one percent) of its shares owned by the Republic of Indonesia. The main objective is to pursue profit. Thus, it is possible that in an SOE Persero, the shares are not only owned by the state but also partially owned by other parties. Therefore, the capital of the SOE is partly or wholly derived from state finances. The type of research used was qualitative research, especially doctrinal legal research. It used a statute approach, collecting data and legal materials through library research and analyzing using qualitative analysis. The research results obtained were state assets that have been transformed into SOE capital whose management was subject to the business paradigm (business judgment rules). However, the separation of state assets does not turn them into SOEs assets which are independent of state assets. Therefore, the operationalization of SOEs is based on both private law and public law.
Examining Iranian physical education teachers’ perceptions of their use of Game-Based Approaches
Authors: Maleki Mohammad , García López Luis Miguel , Gutiérrez Diaz del Campo David
Published: April 2023

This study was conducted to examine the extent to which the key features of Game-Based Approaches (GBAs) are used by Iranian Physical Education (PE) teachers with different genders and educational stages, and to identify the strongest predictors of whether they perceive they are teaching games using GBAs. Through an online survey, 256 PE teachers (123 women, 40.6% primary school) completed the questionnaire designed by García-López et al. (2019), which included questions on games content, planning, teaching strategies and assessment. The results showed that Iranian PE secondary school (SS) and primary school (PS) teachers, in addition to focusing on students' technical development, consider games rules as a key element. They were interested in using thematic approaches and modified games. However, the older the students, especially after the 9th grade, the lower was teachers' engagement with teaching through GBAs. SS teachers introduced more theoretical content and structural, technical and tactical elements than PS teachers. The women used GBAs in their teaching more than the men. The use of tactical problems and tactical complexity in the Iranian teachers’ lesson planning were the strongest predictors of their perception of whether they use GBAs in their teaching. The results highlight that Iranian PE teachers’ teaching style, especially in grades above 9th and in boys, must be taken into account to promote students’ technical and tactical capabilities.
Key Words: Teaching Games, Pedagogy, Sports, Students, Physical Education
Organizational Design: An Overview and a Primer Research for Those of PPPs in the Developing Countries
Authors: Gong Wei
Published: April 2023

Previous studies have stated that PPPs often bring together organizations with strikingly different cultures and that cross-sectoral cooperation between the public and private sectors is complex and time-consuming. Especially in the developing countries, the increasingly dynamic environment faced by interdependent organizations in international PPPs also brings to light the inefficiencies and failures of the hierarchical model in dealing with complex and unstable environmental forces. Because bureaucratic models are of little use given the dynamic and uncertain environment of PPP implementation, new design concepts are imperative. Drawing upon the important concept mentioned by previous studies as an organization structure positioned in an environment that is both dynamic and complex, six types of coordinating mechanisms are worked out (against their antitypes which deter success) as the keys to support the operational success of international PPPs in developing countries. And further this article explains the rationale of my recommended design approaches through six PPPs case example, hoping to provide a feasible scheme for improving the quality of PPPs in developing countries.
To the 100th anniversary of the birth of academician V.A. Nasonova. Pain control in rheumatic diseases: Past and future
Authors: Karateev A. E.
Published: April 2023

Throughout the history of rheumatology, the attitude to pain has changed significantly. In the XIX and early XX centuries, pain was considered only as one of the symptoms, the control of which is secondary to the etiotropic and pathogenetic therapy of rheumatic diseases (RD). However, already in the 30–40s years of the XX century, the treatment of pain becomes an independent task, and for this purpose a wide range of medications and non-pharmacological methods are used. Rheumatologists in Europe and the USA in those years discussed the topic of “neurogenic” and “psychogenic” pain in RD, including “fibrositis”. The works of Russian rheumatologists of 50–60s years demonstrate a different attitude to pain relief in RD: some experts considered it a necessary component of treatment; others attributed it to auxiliary methods that are significantly inferior in importance to pathogenetic therapy.

In the 70s, rheumatologists have at their disposal a large arsenal of painkillers, primarily nonsteroidal anti-inflammatory drugs (NSAIDs). In parallel with the study of their therapeutic capabilities and safety, an active study of the problem of pain in RD begins. Since that time, pain relief issues have been among the main topics of the V.A. Nasonova Research Institute of Rheumatology; its employees organize their own and participate in international projects to study new analgesic drugs. Pain control is beginning to be considered among the priorities of anti-rheumatic therapy. Currently, the rheumatology community is very interested in the problem of “non-inflammatory” pain associated with autoimmune dysfunction of the nociceptive system, central sensitization and fibromyalgia – as a factor determining the insufficient response to anti-rheumatic therapy and poor quality of life of patients with RD.

The V.A. Nasonova Research Institute of Rheumatology, in collaboration with neurologists and algologists, is actively involved in the study of this pathology, studying the phenotypes of pain in different RD, the role of immunological, genetic and psychoemotional factors in nociception, as well as the influence of modern anti-rheumatic therapy (genetically engineered biological drugs and JAK inhibitors) on the main manifestations of RD.
The role of interleukin 17 in the pathogenesis of rheumatoid arthritis. Are there any prospects for the use of IL-17 inhibitors?
Authors: Nasonov E. L. , Avdeeva A. S. , Korotaeva T. V. , Dubinina T. V. , Usacheva Ju. V.
Published: April 2023

Rheumatoid arthritis (RA) is an immunoinflammatory rheumatic disease (IMRI) characterized by chronic erosive arthritis and systemic damage to internal organs, leading to early disability and reduced life expectancy in patients. Thanks to the progress in the study of the mechanisms of the development of the IVRI and industrial biotechnology, new anti-inflammatory drugs have been created, the use of which has significantly increased the effectiveness of the pharmacotherapy of RA. However, the possibilities of pharmacotherapy for RA are limited, since all genetically engineered biological drugs (GEBDs), regardless of the mechanism of action, have approximately the same effectiveness in achieving remission. It is believed that the relatively unsatisfactory results of RA therapy are due to the heterogeneity of the mechanisms of inflammation. and pain. The significance of the Th17 type of immune response in the pathogenesis of RA, the results of controlled studies of IL-17 inhibitors, and the advisability of further studying the effectiveness of these drugs in patients with certain RA phenotypes are discussed.
Efficacy of direct-acting antivirals in patients with hepatitis C virus-associated cryoglobulinemic vasculitis: Results of a long-term follow-up
Authors: Gavrisheva S. V. , Abdurakhmanov D. T. , Bulanov N. M. , Tanashhuk E. L. , Rozina T. P. , Nikulkina E. N. , Milovanova S. Yu. , Nabatchikova E. A. , Filatova A. L. , Starostina E. E. , Krasnova T. N. , Moiseev S. V.
Published: April 2023

Objective – to evaluate the long-term outcomes of HCV eradication with direct-acting antivirals (DAAs) in patients with hepatitis C-associated cryoglobulinemic vasculitis (HCV-CV)

Materials and methods. We retrospectively assessed 48 patients with HCV-CV treated with DAAs. The activity of HCV-CV was assessed by using Birmingham Vasculitis Activity Score version 3 (BVAS v. 3). In patients with HCV-CV the rate of sustained virologic (defined as undetectable HCV-RNA levels 12 weeks after treatment cessation) and immunological (defined as absence of circulating cryoglobulins, rheumatoid factor and normal C4 level) response; and the rate of complete (defined by a BVAS v. 3 score of 0) and partial (defined as BVAS v. 3 score <50% of the baseline score) clinical response were evaluated. Immunosupressants were given before or after DAAs therapy if clinically needed.

Results. Median time of follow-up from treatment cessation were 26,5 (11,5–62,3) months. All 48 (100%) patients achieved sustained virologic response. Elimination of cryoglobulins were reported in 20 (41,7%) patients, complete immunological response-in 4 (8,3%) cases. Complete and partial clinical responses were observed in 13 (27,1%) and 19 (39,6%) patients, respectively. BVAS v. 3 score <4 at baseline was independently associated with complete clinical response (ОR=7,58; 95% CI: 1,42–40,48; р=0,018). 3 (6,3%) patients demonstrated HCV-CV relapse.

Conclusion. Patients with HCV-CV require a long-term follow-up period even after reaching the SVR. The use of BVAS v. 3 score before the DAAs therapy can facilitate the planning of therapeutic approach, particularly, when identifying the patients in whom the immunosupressive therapy should be considered after viral eradication.
Predictive Factors for Complete Resolution of Hypertension After Adrenalectomy for Aldosteronoma
Authors:   University of Tunis El Manar, Faculty of Medicine of Tunis, Department of Endocrinology-Diabetology , Charles Nicolle Hospital, Tunis, Tunisia, Nacef Ibtissem Ben , Khalifa Days ,   University of Tunis El Manar, Faculty of Medicine of Tunis, Department of Endocrinology-Diabetology , Charles Nicolle Hospital, Tunis, Tunisia
Published: April 2023

Introduction: Primary hyperaldosteronism, 1st cause of secondary hypertension, 2nd cause of hypertension potentially curable by surgery. The objective of this work is to determine the predictive factors for complete resolution of hypertension after adrenalectomy. Material: We conducted a retrospective study of 25 patients with primary hyperaldosteronism operated and followed between 1985 and 2018. Results: Our patients were divided into 16 women and 9 men, mean age 54 years. 40% of our patients were smokers, 36% dyslipidemic, 68% diabetic and 76% had a BMI ≥ 25 kg / m2. Patients underwent unilateral adrenalectomy, the surgical approach was posterior lumbar in 9 cases and laparoscopic in 16 cases. No per or postoperative complication was noted. The postoperative course was marked by the HTA in 36% of the cases, an improvement in 36% of the cases and persistence in 31% of the cases. We found a significant decrease of the PAS and the PAD at six months of the surgery. The comparative study of the patients whose HTA was cured versus unhealed did not show a statistically significant correlation with the following predictors of healing: young age, female gender, lack of family history of hypertension, adenoma’s dimension, the presence of comorbidities including diabetes and dyslipidemia and the average number of antihypertensive treatment.Only the absence of overweight or obesity was a predictor of healing in our series. Conclusion: Knowing the predictive factors of healing aims to pose the operative indication and especially to improve the prognosis of hypertension after surgery by acting on certain modifiable factors.
Takotsubo cardiomyopathy -— a case report
Authors: Khan Ali Nawaz , Malik Erum Shahzadi , Admin
Published: April 2023

Takotsubo Cardiomyopathy is a cardiac syndrome of rare type involving apical akinesis of the left ventricle. Symptoms of acute myocardial infarction, i.e. chest pain, S-T changes, and positive cardiac enzymes, are observed in patients with Takotsubo Cardiomyopathy. Cardiac angiography of Takotsubo Cardiomyopathy patients manifest left ventricular apical ballooning with no remarkable coronary artery stenosis. Mostly the cases are managed on the lines of treatment for Acute Coronary Syndrome. We present a case of Takotsubo Cardiomyopathy in a teenage girl from Karachi, Pakistan. The prevalence of Takotsubo Cardiomyopathy in Pakistan is yet to be mapped due to its rarity.
Key Words: Takotsubo Cardiomyopathy, Rare Cardiac Syndrome, Teenage Girl, Karachi, Pakistan.
A comparison between anterolateral thigh perforator flap and abdominal pedicle flap in repair of hand injuries and tissue defects
Authors: Huang Yinwei , Lu Yefeng , Cao Jinlin , Huang Xuehui
Published: April 2023

The purpose of this study was to compare the outcome of anterolateral thigh perforator flap and abdominal pedicled flap repair for treating traumatic tissue defects of the hand. A total of 140 patients with hand trauma tissue defects were randomly divided (random number table) into Group A and Group B, with 70 cases in each group. Group A was given anterolateral thigh perforator flap repair, while Group B was given abdominal pedicled flap repair. The healing time of wounds in Group A was noted to be shorter than that in Group B (P<0.001). At one week after surgery, VAS score, serum IL-6 and TNF-a levels in Group A were 4 times lower than those in Group B (p<0.001 for all). Anterolateral thigh perforator flap repair works more effectively on traumatic tissue defects of the hands than abdominal pedicled flap repair.
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Relation between serum beta-endorpin, neuropeptide Y and thyroid hormone in children with anorexia
Authors: He Xu , Zhao Hongling , Shi Linxia , Wang Wei , Yuan Xiong
Published: April 2023

The purpose of this study was to investigate whether serum B-endorpin and neuropeptide Y were associated with changes in levels of thyroid hormones in children suffering from anorexia. One hundred and five anorexic children admitted to Xianning City Central Hospital, China, from August 2019 to July 2021, were selected as case group, while 105 normal children were selected as normal control group. Serum B-endorpin and neuropeptide Y levels in the case group were lower than those in the normal control group (both P<0. 001), and serum triiodothyronine and thyroxine levels were also lower (both P<0. 001). Serum B-endorpin and neuropeptide Y levels in the case group were positively correlated with triiodothyronine and thyroxine. There is a reduced level of serum B-endorpin, neuropeptide Y, and thyroid hormones in anorexic children, and it is possible that they are connected and work together in regulating ingestion.
Development and validation of a method for the quantitative determination of rotenone in the homogenate of the cerebral cortex of rats by high-performance liquid chromatography (HPLC)
Authors: Gradinar Maria Mikhailovna , Shchulkin Alexey Vladimirovich , Chernykh Ivan Vladimirovich , Yakusheva Elena Nikolaevna
Published: April 2023

Introduction. Rotenone is a neurotoxin that causes damage of dopaminergic neurons in the substantia nigra and is used as a model for experimental parkinsonian syndrome. The development of a technique for the quantitative determination of rotenone in the brain will allow testing new strategies for the pharmacotherapy of parkinsonism by reducing the penetration of toxic substances into the brain.
The aim of the study was to develop and validate an HPLC method for the quantitative determination of rotenone in the cerebral cortex of rats.
Material and methods. Quantitative determination of rotenone was carried out using a Stayer chromatographic system (Аквилон, Russia) with a UV spectrophotometric detector UVV 104 at a wavelength of 296 nm in isocratic mode. A reverse-phase chromatographic column Luna C18 100Å (250*4.6) with a grain size of 5 μm at a temperature of 37°C was used. The composition of the mobile phase was deionized water, acetonitrile in a ratio of 70:30. Determination of rotenone concentration was carried out by the method of absolute calibration by the area of the peaks.
Sample preparation consisted in homogenization of 500 mg of crushed frontal lobe of the rat cerebral cortex in 500 μl of purified water, followed by centrifugation (1750 g), collection of the supernatant and sedimentation of the proteins by acetonitrile. The liquid layer was evaporated on a rotary vacuum. 250 µl of the mobile phase was added to the dry residue, and 100 µl was injected into the chromatograph.
Results. The method was validated for the following parameters: selectivity, linearity, accuracy, precision, limits of detection and determination, sample transfer, sample stability. The analytical range was 62.5−1000.0 ng/g brain with a correlation coefficient of more than 0.99. The limits of detection and quantification of rotenone were 25.0 and 62.5 ng/g, respectively. The calculation of intra- and inter-cycle accuracy and precision showed that these parameters do not exceed 20% for the concentration corresponding to the lower limit of quantitative determination, and 15% for higher concentrations. The stability of the technique was demonstrated during short-term storage at room temperature, three freeze-thaw cycles at –80°C, and storage at –80°C for 60 days. There was no sample transfer.
Limitations. The chromatographic technique makes it possible to analyze the content of rotenone in the cerebral cortex of rats in the concentration range of 62.5–1000.0 ng/g.
Conclusion. A method for the quantitative determination of rotenone in the homogenate of the cerebral cortex of rats has been developed and validated.
Ways to form students' creative abilities in the school mathematics course
Authors:   Khoja Akhmet Yassawi International Kazakh-Turkish University, Tleukeev E. , Ertaev N. ,   Khoja Akhmet Yassawi International Kazakh-Turkish University
Published: April 2023

The article discusses the theoretical foundations and pedagogical features of the organization of students' creative abilities during the development of «creative abilities of students». The factors and conditions that contribute to the skills of students' creative abilities are revealed, didactic units and functions worthy of organizing students' research activities are considered in the mathematical learning process, the structure of which is indicated. In teaching mathematics, the definition of «creativity» is clarified. A pedagogical analysis of textbooks of the natural and mathematical direction is carried out and the advantages in textbooks are indicated. The concept of «creative abilities of students» is considered and problems are given. Scientific research was carried out in the general secondary school «Shokai No. 24». When conducting research work, methods of analysis of pedagogical and psychological literature, pedagogical analysis of creative abilities, observation, survey, pedagogical experiment are used. As a result of the research, search and research, creative tasks aimed at the development of search and research, creative activities of students were compiled. Students were interviewed anonymously. The study involved 57 students, 25 percent of whom were able to complete the tasks in full. Discussing the results of the survey; students who work with additional literature, who are interested in independent search, creative work, were able to complete the tasks. The result of scientific research can be used as an auxiliary tool for specialists in the field of mathematics, who teach algebra courses in the school curriculum, search and Research tasks for the development of search and research activities of students.