bluuebunny/crossref_metadata_2025 huggingface dataset:
TATA KELOLA PERUSAHAAN DALAM KINERJA KEUANGAN MELALUI AGENCY COST
Authors: Sofyaun Ashari , Juniar Asrid , Rahmawati Rini
Published: November 2022

Financial performance in the perspective of governance at the cost of mediating institutions is the research objective. The research was conducted during the period 2013-2021 in state-owned companies that went public with a purposive sampling approach. Managerial ownership, leverage and board size as a representation of corporate governance. In measuring financial capacity, ROA and Tobins'q indicators are used. As a data analysis technique, SEM-PLS multivariate analysis was used. Firm value is significantly affected by leverage, agency costs and return on assets. Leverage and agency costs Significant impact on assets. leverage and board size have a significant impact on agency costs. Leverage and board size were successfully mediated by agency costs in influencing Tobin's q and ROA.
HUBUNGAN TINGKAT PENGETAHUAN GIZI DENGAN PERILAKU PENCEGAHAN HIPERTENSI PADA PEKERJA MUDA USIA 25-40 TAHUN
Authors: Christian Yehuda Ethelbert , Karjadidjaja Idawati
Published: November 2022

Hipertensi atau tekanan darah tinggi adalah peningkatan darah yang dapat disebabkan oleh beberapa faktor yang dapat berakibat pada penyakit kardiovaskuler. Terdapat beberapa faktor risiko yang dapat memicu terjadinya hipertensi, salah satunya yaitu diet yang kurang sehat. Sungguh penting adanya kesadaran bagaimana mencegahnya hipertensi dan salah satunya dengan menjaga pola makan yang sehat. Penelitian ini bertujuan untuk mengetahui rata-rata pengetahuan gizi dan perilaku pencegahan hipertensi pada pekerja muda usia 25-40 tahun serta hubungan antara pengetahuan gizi dan perilaku pencegahan hipertensi. Desain penelitian ini menggunakan observasional analitik dengan pendekatan potong lintang. Pengambilan data menggunakan kuesioner dalam bentuk google form yang berisikan soal tentang pengetahuan gizi dan perilaku pencegahan hipertensi. Hasil penelitian ini menunjukkan bahwa dari pekerja muda usia 25-40 tahun yang diteliti yaitu sebanyak 118 orang, terdapat 13 (11,01%) orang memiliki pengetahuan gizi kurang baik, 75 (63,55%) orang memiliki pengetahuan gizi cukup dan 30 (25,42%) memiliki pengetahuan gizi baik. Sementara itu, berdasarkan data didapatkan 57 (48,30%) orang memiliki perilaku pencegahan hipertensi baik dan 61 (51,69%) dengan perilaku pencegahan hipertensi kurang baik. Analisis hasil penelitian menggunakan uji T-test independen dengan p-value = 0,670; p>0,05. Dari hasil analisis data tersebut, didapat kesimpulan bahwa tidak terdapat hubungan tidak terdapat hubungan yang signifikan antara pengetahuan gizi dan perilaku pencegahan hipertensi. Namun, dari data ini didapatkan bila kelompok dengan perilaku pencegahan baik memiliki rata-rata nilai pengetahuan gizi lebih tinggi sebesar 0,546 poin dari yang perilaku pencegahannya tidak baik
ANALYSIS OF STUDENT ENGLISH COMMUNICATION USING SEMANTIC MAPPING STRATEGY
Authors: Harahap Sri Wida , Amini Sharfina Yusna , Lumbantobing Kesya Nirma
Published: November 2022

Kemampuan berbahasa inggris berpengaruh besar dalam mendorong karier juga memperluas jaringan bisnis dan memungkinkan setiap orang untuk mengejar peluang karier sesuai dengan perubahan yang terjadi dalam perekonomian. Dalam beberapa dekade terakhir, Asia telah menjadi motor penggerak pertumbuhan ekonomi global, dipelopori oleh para pemimpin yang membangun hubungan internasional dan mendirikan perusahaan-perusahaan multinasional. Persaingan perekonomian di sektor swasta mendorong banyak perusahaan secara aktif mengutamakan kecakapan bahasa Inggris dan berinvestasi dalam mengembangkan kemampuan berbahasa Inggris. Kondisi ini mengharuskan penggunaan strategi yang tepat dalam pembelajaran bahasa Inggris. Penelitian ini bertujuan untuk menganalisa tingkat kemampuan komunikasi bahasa inggris mahasiswa menggunakan strategi Semantic Mapping. Hasil penelitian ini menunjukkan bahwa kemampuan komunikasi bahasa Inggris prodi Teknologi Elektromedik berada pada kategori rendah.  Hal ini dapat dilihat dari skor perolehan penguasaan kosa kata. Disamping itu, mahasiswa masih sering membuat kesalahan tata Bahasa yang dapat mempengaruhi makna. Sehingga sering kali makna kalimat yang disampaikan menjadi berubah. Masih banyak mahasiswa yang pengucapan (pronounciation) nya dipengaruhi oleh aksen Bahasa daerahnya masing-masing.
ANALISIS AKSESIBILITAS MENUJU SEKOLAH DI KOTA DENPASAR
Authors: Wedagama Dewa Ayu Trisna Adhiswari , Suthanaya P Alit , Kwintaryana P
Published: November 2022

Pembagian dan pertumbuhan kegiatan pendidikan di Kota Denpasar tidak dapat dikatakan merata, baik dari tingkat dasar hingga tingkat atas. Di penelitian ini dilakukan analisis mengenai aksesibilitas menuju sekolah di Kota Denpasar dimana faktor hambatannya adalah jarak. Aksesibilitas adalah ukuran keringanan atau keamanan untuk mencapai suatu tempat melalui sistem jaringan transportasi. Jika suatu tempat memiliki aksesibilitas yang tinggi, maka sistem transportasi di daerah tersebut dikatakan baik, begitupun sebaliknya. Penelitian ini bertujuan untuk memahami klasfikasi aksesibilitas, perkembangan aksesibilitas serta keseimbangan aksesibilitas menuju lokasi sekolah antar zona di Kota Denpasar selama tahun pengamatan (2012-2016). Dalam melakukan analisis ini  dibutuhkan data sekunder, antara lain peta administrasi Kota Denpasar, peta jaringan jalan di Kota Denpasar, data jumlah sekolah yang ada di Kota Denpasar dari tingkat Sekolah Dasar (SD), Sekolah Menengah Pertama (SMP) dan Sekolah Menengah Atas/Sekolah Menengah Kejuruan (SMA/SMK) baik berstatus negeri maupun swasta. Kalkulasi aksesibilitas dilakukan dengan mengaplikasikan metode statistik deskriptif dan Indeks Hansen. Analisis yang dilakukan mencakup analisis aksesibilitas serta analisis perkembangan aksesibilitas. Apabila nilai aksesibilitas serta perkembangannya diperoleh, kemudian dilanjutkan membuat diagram Z-Score. Diagram Z-Score tersebut akan menunjukkan keseimbangan tingkat aksesibilitas antar zona. Dari pengkajian yang telah dilakukan, untuk tingkat aksesibilitas tinggi di Kota Denpasar dominan di Kecamatan Denpasar Timur dengan nilai aksesibilitas 83,235. Untuk tingkat aksesibilitas yang sangat rendah dominan di Kecamatan Denpasar Selatan dengan nilai aksesibilitas 42,614. Perkembangan aksesibilitas tinggi di Kota Denpasar dominan di Kecamatan Denpasar Selatan dengan nilai aksesibilitas sebesar 8,127. Perkembangan aksesibilitas yang sangat rendah dominan di Kecamatan Denpasar Utara dengan nilai aksesibilitas sebesar 3,311. Keseimbangan tingkat aksesibilitas sekolah di Kota Denpasar dapat diperhatikan dari hasil Z-Score. Hasil Z-Score menunjukkan bahwa terdapat zona-zona yang memiliki nilai aksesibilitas yang rendah dengan kecenderungan perkembangan menurun (kuadran III) dominan di Kecamatan Denpasar Utara.
IMPLEMENTASI PERATURAN PEMERINTAH NOMOR 27 TAHUN 2012 TENTANG IZIN LINGKUNGAN PADA DINAS LINGKUNGAN HIDUP KABUPATEN SAMOSIR
Authors: Manik Oktavya Margaretha
Published: November 2022

Kabupaten samosir merupakan daerah yang berpotensi wisata yang menjadi prioritas Pemerintah Pusat dalam membangun wisata yang mendukung pariwisata terutama perhotelan. Penelitian ini dibuat tujuannya untuk mengetahui faktor atau kendala dalam pembangunan usaha serta implemetasinya. Metode penelitian ini menggunakan metode deskriptif kualitatif dengan waktu pengerjaan selama 3 bulan mulai dari bulan Agustus - Oktober 2018. Lokasi penelitian ini dilakukan di Kabupaten Samosir Analisa data pada penelitian ini dengan tiga tahap yaitu tahap awal penyiapan data, proses data sampai terakhir pada penganalisis data. Hasil penelitian ini menunjukkan bahwa pada kenyataannya Kabupaten samosir belum seluruhnya efektif dalam instrumen pelakasanaan kebijakan berdasarkan PP No.27 Thn 2012 tentang surat izin atas lingkungan. Kekuarangannya dikarenakan tidak adanya pengaturan dalam bentuk menganalisis dokumen yang berakibat pada lingkungan dan pengelolaan Lingkungan Hidup dan Upaya Pemantauan Lingkungan Hidup (UKL/UPL). Penghambat lainnya berasal dari pengusaha itu sendiri dan implementor kebijakan.
IMPLEMENTATION OF E-COMMODITY FOR FARMERS IN ORDER TO FACILITATE THE DISTRIBUTION OF CROPS IN SUKAPURA VILLAGE, KERTASARI DISTRICT, BANDUNG REGENCY
Authors: Supriyadi Hari , Istambul M. Rozahi , Nugraha Ucu , Parlindungan Parlindungan
Published: November 2022

This research was conducted at the Vegetable Farmer Community in Sukapura Village, Kertasari District, Bandung Regency. This study aims to design a distribution system for agricultural products that involves elements of information technology in the form of designing an e-Commodity system. The e-Commodity system can be said to use internet technology to improve and change the main business processes, especially in terms of selling vegetable farm products. The e-Commodity system in addition to cutting distribution channels from farmers to consumers can also provide benefits in managing agricultural products. The approach method used in the distribution system of agricultural products that involves elements of information technology in the form of designing an e-Commodity system in the Vegetable Farmer Community in Sukapura Village, Kertasari District, Bandung Regency uses the Development Live Cycle System (SDLC) as a framework for designing a distribution system for agricultural products that involves information technology elements. The steps/stages are as follows: System Analysis and Design, Design, Application/Coding Development, Testing and Implementation, Maintenance. The findings of this study can be used as reference material in designing a distribution system for agricultural products that involves elements of information technology in the form of designing an e-Commodity system, this aims to collaborate between academia, industry and government in facilitating the distribution of agricultural products and increasing decent work and while at the same time increasing sustainable economic growth by designing and socializing the use of the e-Commodity System that can manage the distribution of agricultural products from upstream to downstream. This research is expected to be a reference in designing a distribution system for agricultural products that involves elements of information technology so that it is hoped that the existence of this e-Commodity System can provide convenience in the distribution of agricultural products and can have an impact on improving welfare for farmers.
PENGEMBANGAN KAWASAN WISATA KABUPATEN SRAGEN MELALUI PERSPEKTIF ENDOGENOUS DEVELOPMENT UNTUK MENINGKATKAN KESEJAHTERAAN SOSIAL MASYARAKAT
Authors: Irawati Shinta Tris , Imelda Johana Debora
Published: November 2022

Kabupaten Sragen mengalami penurunan daya tarik wisata sejak Tahun 2019, penurunan daya tarik wisata telah dipengaruhi oleh pandemic Covid-19, salah satu sektor pariwisata yang terdampak adalah Kawasan Wisata Sangiran yang telah ditetapkan sebagai World Heritage Comitte sebagai Warisan Budaya Dunia dan menjadi potensi pariwisata unggulan Kabupaten Sragen. Fokus penelitian adalah mendeskripsikan dan menganalisis pembangunan Kawasan Wisata Sangiran dengan pendekatan endogenous development dan upaya dalam meningkatkan kesejahteraan sosial bagi masyarakat lokal. Pendekatan penelitian ini adalah kualitatif dan jenis penelitian deskriptif. Wawancara dilakukan terhadap 22 informan dengan menggunakan teknik purposive sampling. Hasil penelitian menunjukkan bahwa terdapat kriteria dari endogenous development dalam pengembangan Kawasan Wisata Sangiran namun belum sepenuhnya telah dijalankan oleh Pemerintah Daerah, serta terdapat upaya yang dilakukan sebagai bentuk meningkatkan kesejahteraan sosial masyarakat lokal.
ANALISIS STRATEGI PEMASARAN DALAM MENINGKATKAN PENJUALAN SEMBAKO MINYAK GORENG PADA USAHA DAGANG JAYA KARYA SIBORONGBORONG
Authors: Sinaga Leonard R , Siregar Hotlin , Siregar Apriani
Published: November 2022

Dalam setiap bidang usaha, strategi menjadi penting karena merupakan rangkaian keputusan dan tindakan yang diarahkan untuk mencapai tujuan perusahaan. Lebih dari itu, pengusaha membutuhkan strategi pemasaran untuk usahanya. Hal ini sangat penting karena merupakan alat fundamental yang direncanakan untuk mencapai tujuan perusahaan dengan mengembangkan keunggulan bersaing yang berkelanjutan melalui pasar yang dimasuki dan program pemasaran yang digunakan untuk melayani pasar sasaran. Penelitian ini dilakukan di

 

Jaya Karya Dagang Usaha yang terletak di Jalan Horas, Kecamatan Siborongborong, Kabupaten Tapanuli Utara. Fenomena yang terjadi adalah target bulanan yang ditetapkan perusahaan tidak tercapai meskipun beberapa strategi telah diterapkan. Tujuan dari penelitian ini adalah untuk mengetahui strategi pemasaran yang tepat dalam meningkatkan jumlah penjualan dan mampu bertahan dalam menghadapi persaingan minyak goreng dasar di Jaya Karya Dagang Usaha Kecamatan Siborongborong. Penelitian ini merupakan penelitian lapangan dengan pendekatan kualitatif deskriptif. Data diperoleh dari pemilik toko, karyawan, dan pelanggan tetap. Metode pengumpulan data dengan observasi, wawancara, dan dokumentasi. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan analisis SWOT, yaitu identifikasi berbagai faktor secara sistematis untuk merumuskan strategi perusahaan. Berdasarkan hasil analisis diagram SWOT dan matriks SWOT dapat diketahui bahwa Usaha Dagang Jaya Karya berada pada kuadran I (Strategi Agresif) dan pada strategi SO, dimana kekuatan dan peluang perusahaan lebih besar dari pada kelemahan dan ancamannya. Strategi SO merupakan strategi yang paling tepat untuk Jaya Karya Dagang Usaha, sedangkan strategi lainnya dapat dijadikan sebagai alternatif strategi untuk referensi dan pertimbangan yang dapat mengembangkan dan meningkatkan penjualan produk Dagang Usaha Jaya Karya. Selain itu, Usaha Dagang Jaya Karya juga dapat menggabungkan strategi ST, strategi WO, dan strategi WT sesuai kebutuhan untuk memaksimalkan strategi pemasaran yang diterapkan.
VAC System Tortesanal: Alternative for the Treatment of Complex Wounds in the Absence of Commercialized Devices
Authors:   Servicio de Cirugía General del Centro de Alta Especialidad “Dr. Rafael Lucio”, Barragán-Morales Jorge Eduardo
Published: November 2022

The vacuum-assisted closure (VAC) technique is a relatively recent procedure that consists of administering negative pressure on the wound in conjunction with a closed environment that decreases edema, facilitating vascularization, oxygenation and healing. In addition, it promotes the formation of granulation tissue. We present the case of an 18-year-old woman with a bloody wound on the anterior side of the left thigh. Surgical washing and negative pressure therapy were performed with an artisanal VAC cure system as there were no commercialized systems, performing the healing technique in a simple and cheap way, using materials easily acquired in the hospital environment. Given the high incidence of bloody injuries and the limited availability of negative pressure systems marketed, it is proposed to carry out an artisanal system that can be carried out in any unit.
YOUTUBE AS A SOURCE OF INFORMATION ABOUT CORONAVIRUS DISEASE 2019 VACCINE
Authors: Kaya Erhan , Özdemir Mikail , Üçer Hüseyin , Koçyiğit Burhan Fatih
Published: November 2022

Introduction: YouTube is a very important source of information. The videos in YouTube provide a message with information. The purpose of this article was to assess the main message of available materials about coronavirus disease 2019 (COVID-19) vaccines on YouTube.

Methods: In this study, the four search terms "COVID-19 vaccine", "COVID-19 vaccination", "Coronavirus vaccine", "Coronavirus vaccination" were scanned on the YouTube (www.youtube.com) media platform on 9 February 2021. We examined video parameters i.e., durations, view counts, likes, dislikes, comments, messages and sources of the 83 videos about COVID-19 vaccine.

Results: The messages were defined as 52 (62.6%) positive, 12 (14.5%) negative, and 17 (20.5%) ambiguous about getting vaccinated. Significant differences were determined between the message category groups in respect of the like ratio (p = 0.014). Positive group videos were less liked.

Conclusion: More negative messages about the COVID-19 vaccine were found in media-sourced videos. Negative and ambiguous videos were more attractive to YouTube users. Scientists, policymakers, and community leaders should play a role in disseminating information about COVID-19 vaccine and vaccination.
UNIVERSAL HUMAN-CENTERED HEALTH COVERAGE IN THE CENTRAL ASIAN REGION
Authors: Brimkulov Nurlan N. , Kapanova Gulnara Zh. , Kalmakhanov Sundetgali B. , Sagitova Aidana R. , Bucaraeva Kurmanjan E.
Published: November 2022

The article discusses the necessity to strengthen action to achieve universal health coverage (UHC), which has been slowed down by the COVID-19 pandemic, considering policy concepts. The dynamics of the UHC index in Kazakhstan and Kyrgyzstan for 2000-2019 is regarded. Several global activities for the development of primary health care and UHC in Kazakhstan are described, confirming the possibility of effective usage of political power to promote the ideas of primary health care, and this experience should be taken into account by other countries around the world.
FROM HIPPOCRATIC OATH TO DECLARATION OF GENEVA: THE EVOLUTION OF ETHICAL VALUES IN MEDICAL PRACTICE
Authors: Gracia-Ramos Abraham Edgar
Published: November 2022

FROM HIPPOCRATIC OATH TO DECLARATION OF GENEVA: THE EVOLUTION OF ETHICAL VALUES IN MEDICAL PRACTICE
Проектирование и разработка компонентов информационной системы образовательного учреждения (на примере проекта автоматизации работы специалиста по научно-исследовательской работе)
Authors: Гумерова Г.Р. , Мансурова Т.Г.
Published: November 2022

В монография представлены результаты проекта автоматизации работы специалиста по научно-исследовательской работе образовательного учреждения. Структура охватывает этапы пред-проектного анализа объекта исследования, проектирования и раз-работки. В конце представлена структура капиталозатрат на реа-лизацию проекта и оценка экономической эффективности реализации.
A Case Control Study To Evaluate The Sensitivity Of Salivary Over Serum Glucose Levels In Patients With Controlled Type 2 Diabetes Mellitus
Authors: M.Hari Kumar MDS  , M Sivakumar  , Angeline Deepthi  , Sheela  , P` Manjima Sasidharan
Published: November 2022

Background: The primary objective of the study is to manage the level of “sensitivity of salivary over serum glucose” in patients whohave been suffering from type 2 diabetes mellitus patients.Materials and Methods: There are two groups have been selected for this study for the purpose of gathering samples. In that case,Group A includes individuals below 60 years, and also their health condition was checked before the selection as a sample. In addition,Group B incorporates 60 adults after observing their diabetes levels. In that case, it can be observed that Group B has successfullycontrolled their type2 of diabetes. In order to determine the glycosylated hemoglobin and serum glucose present in the blood, the bloodsamples (“1.5ml of venous Blood”) were gathered with the help of EDTA. In this context, it is required to use a sterile container tocollect stimulated saliva from each of the groups. In this study, the “microcolumn method” has been used for the estimation of glucoseof the subjected groups. In the next phase, the result can be obtained with the help of statistical analysis with “ANOVA” and “correlationtest”.Results: In every group, the level of salivary glucose has been enhanced and also observed after doing a proper comparison. Thepresence of HbAlCc can enhance the percentage of glucose in a certain group. After doing the correlation Analysis, it can be foundthat a positive result (P<0.001) occurs between the two factors such as “salivary glucose level with HbAlc” and “serum glucose level”.Conclusion: The study has depicted that, salivary glucose can be used as a form of “noninvasive diagnostic aid”. The term diabetes hasbeen influenced by the function and composition of the salivary method.
A Rare Case Of Hoffman Syndrome Presented As Hypothyroid Myopathy
Authors: M. Heshish Reddy  , V.Padma  , Shyni Thomson  , Saketh Raminen  , Sarath Bhaskar
Published: November 2022

Hypothyroidism's neurological manifestations are uncommon as first symptoms, and they usually appear later in the disease's course.Muscle hypertrophy is a very uncommon occurrence in hypothyroid people 1. Hoffmann's syndrome is a kind of hypothyroidism thatmanifests as muscle stiffness and pseudohypertrophy in adults. In most cases of hypothyroid myopathy, laboratory tests reveal elevatedlevels of muscle enzyme. The electro physiological investigation may reveal signs that indicate myopathy, neuropathy, or a combinedpattern of myopathy and neuropathy. Hormone replacement therapy 7 restores symptoms and normalises enzyme levels in the blood.Now, presenting a case of young age male presenting with hypothyroidism having features of calf muscle hypertrtrophy
LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ASSAY METHOD FOR ESTIMATION OF SAXAGLIPTINE AND DAPAGLIFLOZIN IN HUMAN PLASMA
Authors: Vinutha Kommineni  , Jeetendra Kumar Gupta  , Uttam Prasad Panigrahy  , Kurni Lakshmi Deepthi  , Karthickeyan Krishnan  , Chandan R S
Published: November 2022

There has been much research on both saxagliptin and dapagliflozin. However, only a few HPLC and LC-MS methods that use stable labeled isotopes to measure the amount of a drug alone or in combination with other drugs and have a longer chromatographic run time have been published. A quick and sensitive LC-MS/MS mass spectrometric test method has been made and fully validated to find dapagliflozin and saxagliptin in human plasma simultaneously. Solid-phase extraction on the Cleanert PEP-H extraction cartridge was used to separate the analyte and I.S. from the human plasma. The extracted samples were separated on an Ace Phenyl (150 X 4.6 mm, 5 m) column at a set flow rate of 0.8 mL/min using an isocratic mobile phase of acetonitrile and 5 mM ammonium acetate buffer (70:30 v/v). For dapagliflozin, the calibration curve was linear throughout a range of 0.502-227 ng/mL, while for saxagliptin, the range was 0.103-76.402 ng/mL. The procedure was validated in accordance with standards set by the U.S. Food and Drug Administration, and the outcomes are acceptable.
Evaluation Of Platelet Aggregation Activity Depending on The Duration of Antiplatelet Administration in Patients with Coronary Heart Disease
Authors: Khodzhanova Shakhnoza Iskandarovna
Published: November 2022

To study the aggregation activity of platelets in patients with ischemic heart disease depending on the long-term intake of acetylsalicylic acid (ASA). Material and methods. The study included: 116 patients with coronary artery disease with stable angina pectoris, taking a standard dose of aspirin 75 mg/day. during various terms. Patients with SSN were divided into 4 groups according to the duration of taking ASA. Platelet aggregation was measured using a laser platelet aggregation analyzer Alat-2 Biol, with computer processing according to the AGGR program. Adenosine diphosphate (ADP) in concentrations of 0.1, 1.0, 5.0 mmol/l was used as an inductor. The results of the study of patients taking ASA for more than 5 years showed that spontaneous aggregation and ADP-induced platelet aggregation were higher than in patients taking the drug for less than 5 years. Statistically significant differences were observed when compared with a group of patients taking ASA for less than a year (spontaneous aggregation of 1.7±0.09 (p<0.05), 0.1 μm ADP-induced aggregation of 6.58±0.86 (p<0.05), 1.0 μm ADP-induced aggregation of 16.51±1.63 (p<0.01), 5.0 μm ADP-induced aggregation 58.44±3.72 (p<0.01). Conclusion. Thus, the results showed that with an increase in the duration of aspirin intake, there was a change in both spontaneous and ADP-induced platelet aggregation with a statistically significant increase.
Design And Optimization of Midazolam Loaded Microemulsion Using Quality by Design (Qbd) Assisted Statistical Modelling
Authors: Manish Upadhyay  , Vijay Ghori  , M.M. Soniwala
Published: November 2022

Introduction: More emphasize was given in the present work is application of QbD tools and DoE approach. The existing study was aimed towards development and characterization of Midazolam (MZM) loaded microemulsion (ME) for brain delivery through nasal route.Methods: Different QTPP and CQAs were identified initially and REM was prepared. Further D optimal design was employed with concentration of Oil (X1), concentration of Smix (X2) and concentration of water (X3) as significant independent variables (IVs). Globule size (Y1), %Transmittance (Y2) and Viscosity (Y3) were kept as important CQAs.Results: MLR models revealed that selected IVs have great impact on Y1 and Y3, especially main and interactive effect. The results were supported by contour plots (2D and3D) and predicated Vs actual plot. % PE values for check point batches were found less than 5% indicating accuracy of evolved MLR models. Further, control space was mapped from design space of overlay plot and out of control space, one batch was optimized and revised REM was prepared. Revised REM showed low risk potential of various IVs on selected CQAs. Optimized batch was tested for zeta potential, conductivity, Polydispersity index, viscosity, refractive index, isotropic number. Moreover, ex vivo permeation using sheep nasal mucosa in simulated nasal fluid (SNF). The study revealed that superior permeation than Midazolam suspension which is attributed to the incorporation of MZM into ME carrier.Conclusion: So, in a nutshell, it can be concluded that application of QbD approach and DoE concepts in MZM loaded ME yielded design space which will be useful for error free scale up plan implementation.
Optimización de la formulación de la conserva de anchoveta (Engraulis ringens J.) en salsa tipo gourmet por evaluación sensorial
Authors: Pantoja Tirado Lucia Ruth , Aguirre Vargas Elza
Published: November 2022

La anchoveta (Engraulis ringens J.) es una especie distribuida en ecosistemas diferenciados de todo el mundo, siendo una de las más explotadas en la actualidad en el Perú. El objetivo principal de este trabajo fue determinar la formulación óptima de una conserva de anchoveta en salsa tipo gourmet por evaluación sensorial, preparada a partir del Cushuro (Nostoc sphaericum, Vaucher ex Bornet & Flahault), aceite de Sacha Inchi (Plukenetia volubilis L.), Chincho (Tagetes elliptica Sm.), Romero (Salvia rosmarinus L.) y papa (Solanum tuberosum L). Se utilizó un diseño factorial 32, donde los dos factores estuvieron representados por el aceite de sacha inchi, concentraciones (3, 5.5 y 8 %) y el cushuro, concentraciones (7, 9.5 y 12 %). La evaluación sensorial se realizó con 50 panelistas semi entrenados, de ambos sexos y con diferentes edades. Se utilizó el método de aceptabilidad general, evaluando los tratamientos en una escala continua, considerando las variables sensoriales olor, sabor, textura, apariencia, color y aceptabilidad general. La mejor formulación estuvo constituida por 8% de aceite de Sacha Inchi, 12 % de Cushuro, 6% de salsa madre y el resto de los ingredientes con valores estándar para todas las formulaciones, presentando también los mayores niveles nutricionales y adecuados contenidos de aceites omegas 3, 6 y 9. Los contenidos de azúcar, sodio, grasas saturadas y grasas trans en la formulación óptima, estuvieron por debajo de los valores máximos establecidos por Ley en el Perú. La conserva de anchoveta en salsa tipo gourmet resultó un producto comercialmente estéril, apto para el consumo humano.
Carabus variolosus (Fabricius, 1787) (Coleoptera: Carabidae) in Bulgaria: rediscovered after 111 years
Authors: Bekchiev Rostislav , Antov Miroslav , Boyadzhiev Peter , Zaemdzhikova Gergana , Kostova Rumyana , Guéorguiev Borislav
Published: November 2022

The rediscovery of the rare and endangered species Carabus (Hygrocarabus) variolosus is reported after its last record from 1909. The only known locality (Stara Planina Mts, Varshets Town) was confirmed. New records at similar habitats in the region could be expected in the future, based on extensive surveys with the proposed methods.
profesionalización de los estudios filosóficos en Tucumán durante el primer peronismo
Authors: Sosa Paula Jimena
Published: November 2022

La revista Notas y estudios de filosofía ocupa un lugar destacado en el campo filosófico tucumano durante el primer peronismo, pues surge en un marco de fuerte expansión del proyecto universitario, coincidiendo además con el arribo de exiliados europeos a causa de los totalitarismos y del contexto bélico internacional. A su vez, en el plano local, la publicación busca consolidarse en un escenario nacional profundamente politizado.

  El objetivo del presente trabajo es ahondar en el papel de la revista –como espacio de expresión de una intelectualidad que no adscribe al peronismo, pero que permanece en las universidades–, y evidenciar cómo la misma busca construir un canon, atendiendo al modo en que recepciona selectivamente ciertos modelos filosóficos centrales.
Roger Chartier y la historia de la cultura popular
Authors: Burke Peter
Published: November 2022

Roger Chartier y las migraciones históricas de la cultura escrita
Llevar el mundo de los libros al grand public
Authors: Turnovsky Geoffrey
Published: November 2022

Roger Chartier y las migraciones históricas de la cultura escrita
Enseñanza de la ética en el bachillerato
Authors: Mireles Vargas Olivia , García García Carlos
Published: November 2022

Se presenta el reporte de una intervención docente para la enseñanza de la ética en la Educación Media Superior a través del enfoque por competencias. Primero, se contextualiza y problematiza sobre la Reforma Integral de la Educación Media Superior que tuvo lugar en México en el 2008, para observar los cambios curriculares y señalar el lugar de la ética como asignatura en este subsistema y los retos de los profesores frente a estos cambios. Segundo, se presentan los principios teóricos del enfoque por competencias, así como una perspectiva filosófica sobre la enseñanza de la ética basada en la phrónesis, que desde una perspectiva aristotélica es traducida como prudencia, como modelo de ser ético. Tercero, se expone el diseño didáctico, así como los resultados que muestran las experiencias del docente en el aula, el trabajo de los alumnos y los resultados de los procesos de aprendizaje. En la conclusión se analiza el impacto del enfoque por competencias en la enseñanza de la ética, señalando las dificultades y limitaciones, pero también sus posibilidades para el trabajo docente al vincularse con concepciones filosóficas más amplias.
Pliegues y despliegues de la extensión crítica
Authors: Filippi Villar Julieta , Colacci Romina
Published: November 2022

En el presente trabajo se desarrollarán algunos avances del grupo de investigación Feminización de la Extensión Crítica, el cual forma parte del Grupo de Trabajo Extensión crítica: teorías y prácticas en América Latina y el Caribe del Consejo Latinoamericano de Ciencias Sociales (CLACSO). Este grupo tiene como objetivo hacer visibles algunos invisibles que sostienen y reproducen la división social, técnica y sexual de la práctica extensionista, utilizando dos estrategias: 1- constituir la extensión universitaria en objeto de análisis y; 2- revisar su corpus teórico desde las categorías propuestas por los feminismos academicistas y populares. Se presentarán algunos resultados preliminares obtenidos a partir de la lectura sintomal (leer un texto o un corpus teórico no solo por lo que dice sino también por lo que omite o silencia), lo que permite la elucidación crítica de los sesgos sexistas en el interior de las propias prácticas y construcciones teóricas para posibilitar reconceptualizaciones y aportes. Se incorpora además una nueva estrategia de abordaje: el análisis de la implicación subjetiva, para permitir el despliegue de lo opaco, para poder así actualizar la extensión crítica latinoamericana y caribeña y continuar recorriendo, con pasos renovados, los caminos de la extensión critica que ya fueran marcados por otrxs.
Influence of genotype-environment interaction on soybean (Glycine max L.) genetic divergence under semiarid conditions
Authors: Tavares de Albuquerque José Ricardo , Anizio Lins Hamurábi , Galdino dos Santos Manoel , Moreira de Freitas Márcio Alexandre , Sarmento de Oliveira Fernando , Evangelista de Souza Almir Rogério , Silveira Lindomar Maria , De Sousa Nunes Glauber Henrique , Barros Júnior Aurélio Paes , De Melo Jorge Vieira Paulo Fernando
Published: November 2022

The objective of the present work was to evaluate the influence of the genotype–environment interaction on genetically divergent soybean grown under semiarid conditions. Four experiments were carried out in randomized blocks with four replicates to evaluate twenty-one soybean genotypes. The following descriptors were used to quantify divergence: plant height, dry matter, oil content, number of pods per plant, number of grains per pod, the weight of 100 seeds, yield, days for flowering, and days for maturation. The unweighted pair group method with arithmetic mean was used to group the genotypes from the Mahalanobis distance matrix estimated using the genotypic means estimated by the REML/BLUP method. The grouping of genotypes depended mainly on the effects of the interaction between genotypes and years. The joint analysis, without the effect of the interaction, allowed us to obtain two groups of genotypes. The most recommended crosses were those of the lines BRS Tracajá, BRS Pérola, BRS Carnaúba, M 8644 IPRO, BRS 8590, and BMX OPUS IPRO with the genotype BRS Sambaíba, especially the one between BMX OPUS IPRO and BRS Sambaíba.
Highlights

The grouping of genotypes is dependent on the evaluation conditions, mainly due to the effects of the genotype x years interaction.

The use of estimates of the free genotypic means of the interaction obtained in the joint analysis may be a more adequate alternative to define the heterotic groups and, consequently, the crossings to be performed.
The joint analysis, without the presence of the interaction effect, allows obtaining two groups of genotypes.
Glyphosate sprayed on the pre-existing vegetation reduces seedling emergence and growth of forage species
Authors: Rodríguez Adriana M. , Jacobo Elizabeth J. , Grimoldi Agustín A. , Golluscio Rodolfo A.
Published: November 2022

Seeding pastures or forage crops by no-tillage methods usually involves the spray of glyphosate to suppress the existing vegetation. While  many studies found detrimentaleffects of glyphosate on seed germination and seedling growth of the subsequent crop, others found negligible effects. This study aimed to evaluate the effect of glyphosate spraying on germination, seedling emergence and seedling growth of four forage species: Trifolium repens, Lotus tenuis, Festuca arundinacea and Paspalum dilatatum. The experiment was carried out spraying glyphosate on the pre-existing vegetation and on bare soil 1, 30, 60 and 90 days before sowing, and a control  treatmentsprayed with water. Glyphosate sprayed on pre-existing vegetation 1 to 60 days before seeding reduced emergence, while sprayed 1 to 30 or 1 to 60 days before seeding reduced seedlings belowground biomass and root length of all species and aboveground biomass of legumes respect to sprayed 90 days before seeding, sprayed on bare soil, and control treatment. This herbicide would remain active in the soil environment for at least 60 days after spraying when it was previously absorbed by plants, causing a severe damage to seedlings emergence and growth.
Highlights:

Glyphosate sprayed on pre-existing vegetation 1 to 60 days before seeding reduced seedling emergence of Trifolium repens, Lotus tenuis, Festuca arundinacea and Paspalum dilatatum.
Glyphosate sprayed on pre-existing vegetation 1-30 or 1-60 days before seeding reduced seedlings belowground biomass and root length of all species and aboveground biomass of legumes
Gyphosate sprayed 90 days before seeding or sprayed on bare soil did not affect seggling emergence and growth.
Gyphosate would remain active in the soil environment for at least 60 days after spraying when it was previously absorbed by plants.
Nutraceutical effects of organic Selenium and vitamin E supplementation on performance, antioxidant protection and egg quality of Japanese quails (Coturnix japonica)
Authors: De Moura Adolpho Marlon Antoniol , Siqueira Gloria Leonardo , Vasconcelos Melo Thiago , de Souza Moura Guilherme
Published: November 2022

This study evaluated the nutraceutical effects of organic Selenium and vitamin E supplementation on performance, egg quality and antioxidant protection of Japanese quails. Forty-two posture cages with six birds each were randomly set in seven treatments. Each treatment consisted of the addition of 200 IU of vitamin E/kg of feed and increasing levels of organic Selenium. Significant differences were found in α-Tocopherol deposition, enzymatic activity of glutathione peroxidase (GSH-Px) and oxidative bioindicator malondialdehyde (MDA) in egg yolk with vitamin E supplementation. We concluded that supplementing 200mg of vitamin E and 0.30 ppm organic Selenium did not affect bird performance, but improved egg quality and shelf life.
Highlights:

This study evaluated the nutraceutical effects of organic selenium and vitamin E supplementation on egg quality of Japanese quails.

Forty-two posture cages with six birds each were randomly set in seven treatments. Each treatment consisted of the addition of 200 IU of vitamin E/kg of feed and increasing levels of organic selenium.

Supplementing 200mg of vitamin E and 0.30 ppm organic selenium did not affect bird performance, but improved egg quality and shelf life.
De violencias, paliativos y gratificaciones
Authors: Yufra Laura C. , Patagua Patricia Evangelina
Published: November 2022

En el trabajo nos proponemos articular la reflexión sobre la migración de mujeres jóvenes y adultas bolivianas en Jujuy, el acceso y goce de políticas sociales y bienes públicos en destino, atendiendo a las desigualdades de género que inciden en sus trayectorias vitales. A partir de seis entrevistas en profundidad realizadas a mujeres asistentes al Centro de Educación Integral para Jóvenes y Adultos (CEIJA) ubicado en el barrio de Alto Comedero de la ciudad de San Salvador de Jujuy, reconoceremos cómo interpretan los núcleos centrales de sus trayectorias. Nos detendremos en las condiciones de partida, el momento de la llegada y la instalación en Jujuy y la posibilidad de finalizar sus estudios secundarios gracias a su asistencia al CEIJA. Destacaremos las múltiples violencias que las mujeres tuvieron que padecer, algunos paliativos encontrados y momentos gratificantes que reconocen en sus vidas.
Estructura social de la viticultura mendocina
Authors: García Marcos Jesús
Published: November 2022

El presente artículo se propone reconstruir la estructura social del eslabón primario del complejo vitivinícola mendocino en la posconvertibilidad. Para ello se identificarán diferentes posiciones sociales y, a partir de allí, las características distintivas de los agentes socio- económicos de inserción exclusivamente agraria. Se entiende que el entramado de posiciones socio- económicas deriva del grado de desarrollo de relaciones de producción capitalistas en la vitivinicultura, como también de su reverso, la persistencia de formas históricamente precedentes que son funcionales a la reproducción de determinadas asimetrías, jerarquías y vínculos de sujeción en el complejo vitivinícola contemporáneo.De igual manera, el avance del modelo vitivinícola posfordista tras la reconversión vitivinícola, no ha supuesto el abandono de patrones de producción y consumo fordistas, sino su convivencia con las modalidades posfordistas. En el marco de estas combinaciones emergen, en un nivel concreto de análisis, situaciones de clase y relaciones de producción específicas en la viticultura local que pretenderemos exponer.
Herramientas de participación en el proceso de gestión cultural en la Antigua Estación
Authors: Zúñiga Benítez Miriam , Ramírez Rosete Norma Leticia
Published: November 2022

El artículo presenta una propuesta de metodología acción participativa aplicada al caso de estudio, la Antigua Estación de Ferrocarril en el municipio de San Martín Texmelucan Puebla, ante la falta de participación y sensibilización hacia el uso y cuidado de los espacios urbanos con valor histórico patrimonial e industrial. Esta investigación acción se desarrolló en el programa de maestría en Ordenamiento del Territorio de la Facultad de Arquitectura de la Benemérita Universidad Autónoma de Puebla, de la cual se tuvo un proceso participativo para el análisis socio espacial, destacando actores sociales del ámbito cultural y vecinos del área de estudio a través de la aplicación de herramientas como entrevistas, mapeos participativos, reuniones colectivas y principalmente actividades artístico culturales. Estas acciones definidas dentro de un plan estratégico cultural, permitieron reflexionar acerca de la importancia de la gestión cultural en el proceso de apropiación del espacio urbano, promoviendo el derecho a la ciudad y la cultura, contribuyendo al conocimiento, aprendizaje y reflexión para la mejora del entorno, la transformación social y el desarrollo urbano.
Hacia una Sociología de la Infancia Latinoamericana
Authors: López María Eugenia
Published: November 2022

El presente escrito presenta como principal objetivo indagar y profundizar acerca de las posibilidades de desarrollo de la Sociología de la Infancia como espacio en emergencia reciente a nivel global desde América Latina como espacio específico de producción de conocimiento. De este modo, se dará lugar a un intento por reconocer a grandes rasgos, los desafíos y obstáculos epistemológicos que supone el estudio de las infancias configuradas en el sur global, mediante la propuesta de Sousa Santos (2006). A su vez, se atenderá el hecho de que esta vacancia académica derivada de la reciente emergencia de esta disciplina podría representar una apertura a la posibilidad de desarrollar desde la raíz, una sociología desde y para las infancias en América Latina.
Utility of serum interleukin-18 (IL-18) as a tumour marker in gastric cancer
Authors: Lobo Lancelot , Rohith M. James , Kumari N. Suchetha , Prasad H. L. Kishan
Published: November 2022

Introduction: Gastric cancer (GC) is the fourth most prevailing cancer globally, attributing to more than 70% of cases in developing countries. Protein cancer biomarkers, such as CEA, CA- 125, AFP and PSA, are clinically helpful diagnostic tools, but they have low sensitivity and specificity for GC. Hence, it is essential to discover better markers for GC diagnosis. Interleukin-18 (IL-18) is the member of Interleukin-1 family. It is hypothesized to be a potent inhibitor of gastric acid secretion, leading to gastric atrophy and causing an increased risk of GC. This study was to evaluate the association between the serum IL-18 in GC.
 
Methodology: We included cases who underwent UGI Scopy and were proven to have GC histopathologically. The patients who presented to the out-patient who underwent UGI scopy and was found to have no growth were selected as controls. Twenty-eight cases and 84 control sample sizes were derived from nMaster V2. Blood samples from patients and controls were collected, and serum IL-18 levels were estimated using a solid-phase sandwich ELISA method.
 
Results: We found that the cut-off value of serum IL-18 was 85.59 pg/ml, had a sensitivity of 63.1% and specificity of 57.1%, with a positive predictive value of 81.5% and a negative predictive value of 34% in diagnosing GC. The study plotted the receiver operating characteristic curve against IL-18 for sensitivity and specificity. Statistically, we found through the Area Under the Curve (AUC) that the rise in serum IL-18 levels was a poor indicator of GC with a p-value of 0.078.
 
Conclusion: Statistically, a cut-off of 85.59pg/ml showed good sensitivity and specificity; however, the probability was insignificant, suggesting that IL-18 may not be of diagnostic importance. Studies with a larger sample size are required to further probe into the usefulness of estimating IL-18 in GC.
Changes in biochemical, immunological and inflammatory parameters in hyper and hypothyroidism: A systematic review
Authors: Paliwal Shikha , Pathak Vinay , Kant Ruchi
Published: November 2022

This review presents an assessment of alterations in various biomarkers in hyper and hypothyroidism. In hyperthyroidism, the level of thyroid hormone increases while it decreases in the case of hypothyroidism. The thyroid gland has been implicated in a broad spectrum of carbohydrate metabolism, imbalance of lipid profile, and mineral metabolism. Autoimmunity and inflammatory reactions in the thyroid gland might lead to the conditions like hyper and hypothyroidism. Lipid profile dysfunction is common in hypothyroidism patients while a higher level of liver enzymes is associated with hyperthyroidism. Glucose level has been observed to increase in both conditions. Hypothyroid patients are more prone to autoimmune conditions in comparison to hyperthyroid patients. According to the type of thyroid disorder, the concentrations of various biochemical, immunological and inflammatory markers alter. The literature reviewed in this article establishes considerable changes in the above parameters among thyroid patients which might help further in the early diagnosis and management of thyroid dysfunctions.
Petals of rose: Application of rapid on-site evaluation in bronchoscopy
Authors: Bhowmik Sayan , J. Thanka , Manikandan Aswin , Ravichandar Sabarinath
Published: November 2022

In present day scenario, procedures that are minimally invasive like FNAs and Core needle biopsies are on the rise. Rapid on-site evaluation (ROSE) is a laboratory service that assesses the cytomorphologic features from FNA smears or biopsy contact imprints in the biopsy room and can provide on the spot input and suggestions for the clinician through immediate cytological examination of the biopsy sample. ROSE also allows for a preliminary diagnosis, allowing for the requirement of additional material for ancillary studies. We are presenting two cases which highlights the merits of ROSE in cytological diagnosis.
 
In the first case, a thirty four year old male patient came with complaints of productive cough, breathlessness and fever. Bronchoscopic needle aspiration and biopsy was done with Rapid Onsite Evaluation. ROSE revealed two non-caseating epithelioid granulomas on the 4th pass. Bronchoscopic lymph node biopsy was non- contributory. With other clinical and biochemical parameters, diagnosis of Sarcoidosis was made. This case study underscores the significance of ROSE in arriving at the diagnosis.
 
In the other case, a fifty seven year old male patient came to hospital with productive cough and breathlessness (MMRC grade II). CT chest revealed features suggestive of bronchogenic carcinoma. ROSE was performed along with bronchial brush cytology in which presence of atypical cells with increased nuclear cytoplasmic ratio, nuclear hyperchromatism and nuclear molding was noted. On histopathological examination, it was diagnosed as a case of non-small cell carcinoma of lung – poorly differentiated type. This case proves the advantage of ROSE in avoiding repeated invasive procedures for the patient.