bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGEMBANGAN BAHAN AJAR MATA KULIAH MATEMATIKA DISKRIT BERBASIS KONSTRUKTIVISME
Authors: Siregar Majidah Khairani , Yenti Feprina
Published: February 2019

Tujuan penelitian ini adalah mengembangkan bahan ajar berbasis konstruktivisme yang valid, praktis dan efektif pada mata kuliah matematika diskrit. Bahan ajar yang dikembangkan berupa buku kerja matematika diskrit berbasis konstruktivisme. Penelitian ini termasuk dalam penelitian pengembangan dengan yang terdiri dari 3 tahap yaitu: tahap Pendefenisian, tahap Perancangan dan tahap Pengembangan. Hasil penelitian menunjukkan bahwa (1) bahan ajar dinyatakan valid oleh validator, yang artinya bahan ajar valid dan sudah dapat digunakan oleh mahasiswa yang mengambil matakuliah Matematika Diskrit di STKIP Ahlussunnah. Dan hasil analisis validasi RPKPS termasuk dalam kategori valid, artinya RPKPS yang digunakan sudah sesuai dengan bahan ajar yang digunakan. (2) Analisis hasil angket diperoleh dalam kategori praktis, yang artinya bahan ajar mudah digunakan. 3) Analisis hasil tes menunjukkan bahwa nilai rata-rata hasil ujian mahasiswa berada pada tingkat baik. Dengan demikian dapat disimpulkan bahwa bahan ajar sudah valid praktis dan efektif. Kata Kunci: Pengembangan; buku kerja; valid; praktisjuan penelitian ini adalah mengembangkan bahan ajar berbasis konstruktivisme yang valid, praktis dan efektif pada mata kuliah matematika diskrit. Bahan ajar yang dikembangkan berupa buku kerja matematika diskrit berbasis konstruktivisme. Penelitian ini termasuk dalam penelitian pengembangan dengan yang terdiri dari 3 tahap yaitu: tahap Pendefenisian, tahap Perancangan dan tahap Pengembangan. Hasil penelitian menunjukkan bahwa (1) bahan ajar dinyatakan valid oleh validator, yang artinya bahan ajar valid dan sudah dapat digunakan oleh mahasiswa yang mengambil matakuliah Matematika Diskrit di STKIP Ahlussunnah. Dan hasil analisis validasi RPKPS termasuk dalam kategori valid, artinya RPKPS yang digunakan sudah sesuai dengan bahan ajar yang digunakan. (2) Analisis hasil angket diperoleh dalam kategori praktis, yang artinya bahan ajar mudah digunakan. 3) Analisis hasil tes menunjukkan bahwa nilai rata-rata hasil ujian mahasiswa berada pada tingkat baik. Dengan demikian dapat disimpulkan bahwa bahan ajar sudah valid praktis dan efektif. Kata Kunci: Pengembangan; buku kerja; valid; praktis
Effect of vertigo on the quality of life of elderly patients with hypertensive encephalopathy
Authors: Yavorsky V.V.
Published: February 2019

Combined betahistine dihydrochloride-based therapy improved the performance of scales characterizing the vertigo along with the accompanying symptoms. The effect is comparable to the treatment groups of elderly patients with hypertensive encephalopathy. Vertigo is caused by abnormalities of venous outflow from the cranial cavity due to the increase of arterial pressure, which suggested the use of combined therapy.
Peculiarities of hypertension during acute and early regenerative period repeated ischemic stroke in patients with recurrent stroke
Authors: Lipko V.
Published: February 2019

To evaluate possible features of MRI lesion localization, we examined 30 patients with recurrent stroke. We have examined the localization of cerebral atrophy changes, lacunar infarction, acute ischemic lesions and postischemic changes lesions. The research showed that cerebral atrophy changes significantly grow along with the progression of the disease. In patients with recurrent ischemic stroke, we established significant correlation (p <0.01) of average difference in clinical and ambulatory blood pressure monitoring, which should be taken into consideration when choosing antihypertensive drugs. When analyzing the dynamics of reduction of blood pressure after 4 weeks and 6 months of treatment we saw a significant drop in blood pressure compared with baseline after the onset of ischemic stroke, which can be used when choosing a treatment strategy.
Features of risk patients with recurrent ischemic stroke
Authors: Mikitay O.M.
Published: February 2019

Increasing the number of cases of stroke is due to in- crease the prevalence of major risk factors, such as age and various cardiovascular events such as myocardial infarction, heart disease, hypertension, and especially atrial fibrillation. In order to analyze the incidence of risk factors in patients with recurrent ischemic stroke were examined 60 patients. Among the examined patients in the two groups revealed that hypertension suffered 83.3% of the patients, 75% of patients in the group with a primary stroke and 92.2% of patients in the group with recurrent stroke. A significant increase in patients with hypertension 3-st. (р<0,05) during the second stroke, that was characterized by the accuracy (p<0,01) increase in the severity of stroke, compared with a group of primary stroke (respectively 67.9% and 28.1%). In patients with recurrent stroke occurred more frequently hypertensive cerebral crises (respectively, 73.1% and 62.5%) despite the fact that antihypertensive therapy and blood pressure control was more controle than in the group with primary stroke. Comparative analysis of anamnestic data in both groups was found heredity of chronic heart failure and coronary artery disease, which significantly more common in patients with recurrent stroke (p<0.01). Thus, consideration of comorbid diseases and risk factors in the treatment and prevention of ischemic stroke is of great preventive value, especially during the second stroke.
Uncontrolled hypertension in patients with chronic ischemia of the brain
Authors: Svyrydovа N. K. , Lubenets G. S.
Published: February 2019

The incidence of hypertension is an independent risk factor for cerebrovascular disease. A special problem is uncontrolled hypertension, with the progression of which is 7 times more likely to develop chronic ischemia. At the present stage of diagnosis and treatment of uncontrolled hypertension hypertensive crises is the problem as critical state. Violation of cerebral hemodynamics and function of the brain in patients with chronic brain ischemia determine the clinical picture of hypertensive crisis complicated course. The article highlights the theoretical foundations of the mechanisms of etiopathogenetical, clinical course, diagnosis and modern aspects of the treatment of chronic brain ischemia in the development of hypertensive crisis. The results of their research on the changes of regional cerebral blood flow, cerebral blood flow parameters or transient change in the substance of the brain after hypertensive crises using modern research methods: daily monitoring of blood pressure and single photon emission computed tomography.
The new strategy of treatment of cognitive impairment
Authors: Svyrydova N.K.
Published: February 2019

The initial manifestation of memory impairment is mild cognitive disorders characterized by mild signs of memory impairment, and / or general cognitive decline in the absence of data for the presence of dementia syndrome and prevent the possibility of cognitive impairment due to any cerebral or systemic disease, organ failure, intoxication (in including medical), depression, or mental retardation. The severity of cognitive deficits in patients with cerebrovascular disease are more correlated not with territorial infarcts caused by the defeat of major cerebral arteries, and on microvascular pathology (a minor heart attack, multiple lacunar infarcts, microbleeds), as well as cerebral atrophy, which may be due to vascular brain damage and specific neurodegenerative process. Since effective therapeutic drugs treat persistent cognitive impairment in the present does not exist, an alternative could be a strategy of weakening the development of cognitive impairment and their progression.
International clinical protocol of vestibular disorders (dizziness)
Authors: Trinus K.F. , Claussen K.F.
Published: February 2019

Vertigo - a common symptom, which traditionally presents the results of vestibular dysfunction and non vestibular dysfunction. Vertigo refers to violations of orientation in space. The main symptoms, which produce the patients in the survey: dizziness, subjective vertigo, dizziness objective, pseudo vertigo, imbalance, kinetosis. In many cases, dizziness is functional, rather than an organic nature. Diagnosis of the causes of vertigo arises from the concept of the structure of the vestibular apparatus, the main idea of which is the formation of vertigo in the vestibular system. Morpho-physiological, vestibular system consists of four main projections: vestibular-cortical (sensory), vestibular-motor, vestibular-autonomic and vestibular-limbic. One of the main methods of research of a condition the vestibular apparatus and projections are vestibular evoked potentials (VEP). Owing to this method, have been established objective limits to the sensitivity of the movement. Research of vestibular-spinal responses are based on Romberg test, Unterberger-Fukuda test and Uemura test. Evaluation and treatment of patients with dizziness will differ significantly once the category of dizziness has been determined
Evaluation of neurological deficits in patients with chronic ischemic brain against the background of angina
Authors: Ingula N. І.
Published: February 2019

Coronary heart disease remains the dominant morbidity and mortality of cardiovascular diseases and is an important medical and social problem. In 2012 in Ukraine mortality from diseases of the circulatory system accounted for 66.3% of the total; about half of them - from CHD. One form of CHD is stable angina, which can occur for a long time without complications. However, studies have shown that the mortality rate in patients with chronic ischemic heart disease mortality is comparable to patients with acute myocardial infarction. More than half of patients with angina severity of symptoms severely limits their daily activities and often leads to premature loss of efficiency. Based on studies using anamnesis, risk analysis, clinical and neurological examination, laboratory investigations, electrophysiological examination methods, techniques of neuroimaging (magnetic resonance imaging) showed that in patients with chronic ischemia of the brain against the background of stable angina neurological deficit significantly increases due to myocardial infarction.
Comorbidity in cardioneurology
Authors: Kravchuk N. , Svyrydova N. , Parnikosa T. , Sereda V. , Dovgiy I. , Cherednichenko T.
Published: February 2019

The problem of comorbidity in cardioneurology is one of the urgent problems of modern health care system. When comorbidity main cause of death in the vast majority of patients is cardiovascular and cerebrovascular pathology. The most severe form of disease is stroke. Heart failure - a new epidemic of cardiovascular disease, which manifests itself as one of the major risk factors for stroke.
Visual and oculomotor disorders in patients with multiple sclerosis in connection with comorbidity
Authors: Chupryna G.
Published: February 2019

Conducted study visual and oculomotor disorders in patients with multiple sclerosis (MS) to identify the features of their occurrence and determination due to the performance quality of life, level of fatigue, depression, pain, cognitive impairment in terms of comorbidity. It examined 207 patients with different forms of MS course. The average prevalence of visual impairment in our studied patients with MS was 56.0% and -81.2% oculomotor disorders. It was found that in patients with MS comorbidity, visual disturbances and oculomotor disorders have greater prevalence and severity. The severity of visual disorders are closely correlated (p <0.05) with the level of depression and cognitive impairment, and the severity of the eye disorders - fatigue level of p <0.05.
The dynamics of neurological status in patients with stroke against the background of cardiovascular comorbidity during hospital stay
Authors: Mykytei O.
Published: February 2019

To date, accumulated a large amount of published data that describe in detail the various manifestations of vascular comorbidity and their role in the development of stroke. The presence of comorbidity worsens the prognosis of recurrent ischemic stroke has a significant impact on its diagnosis and treatment and leads to reduced effectiveness of rehabilitation, followed by disability patient. The aim was to assess the dynamics of neurological status in patients with stroke against the background of cardiovascular comorbidity during the hospital stay. During the study found that cardiovascular comorbidity adversely affect the dynamics of the functional status of patients with recurrent ischemic stroke, significantly alters the course of stroke and significantly affect its diagnosis and treatment.
The condition of the ischemic stroke: clinical cause
Authors: Svyrydova N. , Ingula N. , Bieliakova І. , Ruda N. , Pidgirna K. , Shcherbaty A.
Published: February 2019

Cardiovascular diseases (CVD) – represent between 30 percent to 50 percent of all cardiovascular system’s diseases, and account 110 thousands of new stroke cases every year in Ukraine, death rate during first 30 days is 30-40 % and 50 % during 1st year. Primary stroke morbidity is higher in 1.5-2 times than world’s average. The most significant risk factors of stroke are hypertension, heart diseases (coronary artery disease, heart rhythm disorders), transient ischemic attack in anamnesis, diabetes, atherosclerosis (dyslipidemia). According conducted researches it is proven, that level of systolic blood pressure correlates with decreased risk of stroke in patients with hypertension. This article describes a case from clinical practice – management of patient with acute ischemic stroke. The attention is focused on the methods of examination, basic treatment strategy and rehabilitation of patient with this pathology.
Glutathione system state in a hemolysate of erythrocytes among the patients with chronic cerebral ischemia
Authors: Demchenko A.V.
Published: February 2019

The purpose of the work is to study a glutathione system (level of reduced glutathione and activity of glutathione-dependent enzymes) in a hemolysate of erythrocytes among the patients with chronic cerebral ischemia (CCI).

It was examined 287 patients with CCI and 50 healthy people without any signs of cerebrovascular disease using clinical and neuropsychological, laboratory and instrumental methods of investigation. It was established a significant decrease of the reduced glutathione concentration, the decrease of glutathione reductase and glutathione peroxidase and the increase of glutathione transferase activity in a hemolysate of erythrocytes among the patients with chronic cerebral ischemia in comparison with these rates among healthy people. It was established a negative correlated connection between the level of the reduced glutathione, the age of the patients (r=-0,34, р<0,0001), the stage of discirculatory encephalopathy (DE) (r=-0,50, р<0,0001), intima media complex thickness of carotid arteries (r=-0,29, р=0,009), the level of homocysteine (r=-0,81, р<0,0001) and also the level of glutathione peroxidase, the stage of DE (r=-0,39, р<0,0001) and homocysteine level (r=-0,60, р<0,0001).
Alternative analgesics: the possibility of B vitamins
Authors: Svyrydova N.
Published: February 2019

Several studies have shown antinociceptive effects and antigiperalgezichesky using thiamine, pyridoxine and cyanocobalamin on hyperalgesia models suggested that the combination of the result of the activation of thiamine, cyanocobalamin, pyridoxine increase the synthesis and secretion of serotonin in various parts of the brain. Furthermore, the analgesic effect of vitamin B, associated with increased inhibitory control of afferent nociceptive neurons in the spinal cord and the decrease in thalamic neurons of nociceptive stimulation response. The results of the analysis of the effectiveness of the drug Vitakson having analgesic effect. The study confirms the clinical experience with the high efficiency of B vitamins in the treatment of acute back pain (lumbago). Monotherapy Vitakson accompanied by significantly greater (p <0.05) reduction in the intensity of pain in lumbago throughout the course of treatment (10 days) in the substantial absence of undesirable side effects.
Analysis of interference factors in the analysis provdennya neuropsychological characteristics of patients with recurrent ischemic stroke
Authors: Mykytei O.
Published: February 2019

Executive functions yavlyayuyut a complex cognitive domain, which affects and depends on the behavior, emotional state, motor and other cognitive impairment patients, especially in patients with brain disasters. Executive dysfunction can compromise the patient's functional status, due to interaction with depression, emotional instability, motor disorders and movement disorders, leading to deterioration of quality of life. The aim was to analyze the interference factor in the analysis of neuropsychological characteristics of patients with recurrent ischemic stroke to optimize re-diagnosis of acute cerebral ischemia. During the study it was found that the dynamics of the functional state of patients depends on a high degree of interference in the performance of Stroop test, due to the difficulty in differentiation, switching attention and adaptation associated with increased anxiety.
Back pain is a common cause of treatment to a neurologist
Authors: Svyrydova N.
Published: February 2019

Pain - one of the most common reasons for handling to a neurologist. Approximately 80% of the population is plagued at one time or another by back pain, especially lower back pain. Nervous system detects and interprets a wide range of endogenous and environmental irritants. Pain mediated by nociceptors, through the peripheral sensory neurons that signal potential damage to the skin via stimulus conversion into electrical signals that are relayed to higher brain centers.
Всеукраїнська школа неврологів: стратегія 2017 року
Authors: Svyrydova N.
Published: February 2019

Школа неврологів надає унікальну можливість лікарям багатьох спеціальностей почерпнути нові знання, досвід, ознайомитись з новинками в сфері діагностики та лікування різноманітних захворювань, в тому числі і в неврології.

Створена школа неврологів за допомогою «Всеукраїнської асоціації по неврології та рефлексотерапії» під керівництвом Свиридової Наталії Костянтинівни, яка започаткувала проведення різних майстер-класів тренінгів з міжнародною участю.

Практичні заняття проводять висококваліфіковані спеціалісти, талановиті молоді вчені, а також іноземні доповідачі. На кожній школі неврологів присутні більше 100 лікарів різних спеціальностей зі всієї України.
Еvaluation data somatosensory evoked potentials and electromyography in patients with multiple sclerosis in the aspect comorbidity
Authors: Chupryna G. , Svyrydova N. , Parnikoza T.
Published: February 2019

The paper shows the results of electrophysiological methods of investigation in patients with multiple sclerosis (MS) in the aspect of comorbidity. The studies of somatosensory evoked potentials (SSEP) in 216 patients with MS and electroneuromyography in 158 patients with MS, together with the assessment of neurological and psychological status. It is shown that according SSEP increase latency peripheral response in a progressive course of MS compared to remitting associated with older age of patients with progressive MS, and due to involvement in the pathological process of the peripheral nervous system (PNS) and the prevalence of pain syndrome (PS) in patients MS with comorbidity. It is demonstrated, on the basis of electroneuromyographic that MS patients with comorbidity tends to be deeper shock PNS. The data electroneuromyographic clinically appropriate initial stage of sensory or sensorimotor polyneuropathy, which proceeded in 84.8% of patients with MS subclinical and 15.2% had a clear clinical signs.
Рeculiarities of experimental-motivation states in psychologically disadapted patients with multiple sclerosis
Authors: Trufanov Y. , Svyrydova N. , Chupryna G. , Parnikoza T. , Mykytei O. , Svystun V.
Published: February 2019

The objective of our research was to study the clinical ratios between the neurological, demographic and medical-psychological parameters in patients with multiple sclerosis. 89 patients with multiple sclerosis were questioned at time of routine clinic visits. Medical-psychological examination was carried out with the help of the Luscher Color Test.

Neurological manifestations (severity of disease, type of the clinical course, duration, age at disease onset) and demographic manifestations (age and gender) of multiple sclerosis have been found to be connected with the dynamics of the level of emotional intensity, the type of vegetative balance and the level of working capacity of patients.
Analysis of clinical-demographic characteristics of patients with multiple sclerosis in the context of comorbidity
Authors: Chupryna G. , Svyrydova N. , Parnikoza T. , Trufanov Y.
Published: February 2019

Multiple sclerosis (MS) – a chronic inflammatory demyelinating disease of an infectious-allergic origin, which begins mostly in young age, affects mainly female subjects, manifests itself as signs of a multifocal lesion of the central nervous system, has a remitting, less progressive nature of the course, often.leads to disability. Aim: to analyze the clinical and demographic characteristics of patients with MS in the aspect of comorbidity. We examined 216 patients with MS with different types of course. The patients with MS of the general sample were divided into 2 groups: without concomitant diseases (WCD,n = 109) and with the presence of concomitant diseases (PCD, n = 107). A detailed analysis of the clinical anddemographic characteristics of patients with MS in the aspect of comorbidity (WCD and PCD groups) was conducted. Gender differences in gender differences were insignificant (p> 0.05) when analyzing WCD and PCD groups according to age, gender characteristics,duration of MS and its course, while differences in age and clinical features of the disease were found to be emphasized deeper manifestations of MS in patients with PCD group. From the obtained data, it follows that in the PCD group there is a significant increase in the frequency of comorbidity in the course of MS, and the concomitant pathology in MS in the PCD group was significantly more common in patients with a PC duration of 11 years or more.
Analysis of the connection of the concentration of iron in basal nuclei with cognitive impairments in patients with hypertension and atherosclerotic encephalopathy in the study of changes in the magnetic susceptibility of the subcortical structures
Authors: Petrenko M. , Grabovetskii S.
Published: February 2019

Vascular diseases of the brain are an important medical and social problem that negatively affects the economy of the country and the life of society as a whole. Discirculatory encephalopathy refers to slowly progressing disorders of the cerebral circulation, in which development of an essential role is played by hypertension, atherosclerosis, diabetes mellitus and other diseases that affect the vessels of the brain. The purpose of the study was to identify a specific pattern of iron accumulation in the subcortical structures of the brain of hypertensive and atherosclerotic encephalopathy patients to improve the diagnostic criteria for the development of cognitive impairment. For the study, 20 patients in the main group with a diagnosis of hypertensive and atherosclerotic encephalopathy were selected, and the control group consisted of 20 patients, the results of which neuropsychiatric tests were within the normal range. According to the results of the study, the accumulation of iron in the basal ganglia is higher in patients with the main group compared with the control group. The exact mechanism for increasing the concentration of iron in the basal ganglia of the patients in the main group is not known, but this study confirms that deposition of subcutaneous iron may be used as a biomarker for early diagnosis of vascular dementia that develops against the background of hypertensive and atherosclerotic encephalopathy.The results of the study reliably established the existence of a negative correlation between hypointensity of subcortical nuclei and neuropsychological parameters in patients with the main group.
Vertebrogenous syndrome, lumbosacral spine against the backdrop of connective tissue dysplasia in athletes
Authors: Pyantkovsky A.
Published: February 2019

In Ukraine, according to WHO, the disease of the spine is the fourth after cardiovascular system, oncology and pathology of diabetes. Dysplasia of connective tissue (DST) - a violation of the structure of the connective tissue in the embryonic and postnatal period as a result of genetically modified fibrylohenez extracellular matrix, leading to frustration on tissue homeostasis levels prohradiyentnym course. A clinical and neurological examination of 90 patients with an average age of 31,5 ± 13,5 g. оf vertebral syndrome, lumbosacral spine.

The results of the clinical study demonstrated that patients with vertebral syndrome, lumbosacral spine against the background displays GOST significantly (p <0,05) more common intervertebral disc protrusion, more pronounced changes in yellow ties, in the form of thickening. Concomitant diseases (manifestations DST) scoliosis, kyphosis, kyphoscoliosis, hiperruhlyvist joints, tendency to dislocation, stretching ligaments joints - significantly (p <0,05) increase the duration of treatment and the severity of pain. Analysis of the survey data and monitoring of patients in the dynamics of the treatment showed that patients with vertebral syndrome, lumbosacral spine against the background displays GOST significantly (p <0,05) more likely to have anatomical changes in the lumbosacral spine, than in patients without evidence of DST.
Increased sympathetic tone of the autonomic nervous system as a factor for coronary heart disease
Authors: Ingula N. , Svyrydova N.
Published: February 2019

Cardiovascular disease (CVD) in the XXI century continues to hold the lead as the leading cause of death worldwide and in Ukraine (65.2%). Coronary heart disease (CHD) is the leading place among the causes of death and disability in working-age people worldwide. In Ukraine, the analysis of mortality from CHD is 491.91 per 100 thousand population. Numerous epidemiological studies have shown that the increased activity of the sympathetic nervous system (SNS) leads to an increase in cardiovascular disease and mortality. It is known that SNS may participate in the formation of atherosclerosis by activating platelets with the subsequent formation of platelet growth factor and contributes to mechanical damage to the vessel wall as a result of high blood pressure and increased blood flow velocity. There are data on the mechanisms of interaction of SNS the vascular endothelium. Vasoconstrictor effect of endothelin-1 plays an important role in the pathogenesis of various cardiovascular diseases, among which includes the CHD.
Features of the seminar "Analysis of the use of methods of acupuncture diagnostics" on the cycle of specialization in reflexology
Authors: Chupryna G. , Svyrydova N. , Parnikoza T.
Published: February 2019

The paper shows the ways of optimizing the training of doctors on the specialty «Reflexotherapy». The experience of organization of seminars, clinical analysis of patients is given. Presented clinical cases of analysis of these methods of acupuncture diagnostics in patients with multiple sclerosis.
Analysis of the state of the autonomic nervous system, risk factors for the development of cardiovascular diseases in patients with chronic cerebral ischemia and chronic heart failure
Authors: Zhhilova N.
Published: February 2019

This article describes the definition of the state of the autonomic nervous system in patients with chronic cerebral ischemia and chronic heart failure. It has been established that in patients with a reduced left ventricular ejection fraction was recorded the prevalence of the sympathetic link of the autonomic nervous system. Since the activation of the sympathetic nervous system is often a predictor of the development of diseases of the cardiovascular system, the detection of an increase in the activity of the sympathetic department of the autonomic nervous system in the early stages is one of the key moments in preventing the progression of diseases of the cardiovascular system.
Lecture of the cycle of specialization in reflexology "Theoretical and methodological bases of reflexotherapy"
Authors: Svyrydova N. , Chuprina G. , Parnikoza T. , Sereda V. , Khanenko N. , Cherednichenko T. , Svystun V. , Yelizarova О.
Published: February 2019

When conducting the lecture course in the field of reflexology, the mandatory direction is the development of the theory of "INN-YAN", which considers the question of a concrete objective event: IN and YN carries the conditional division of all phenomena of nature into two opposite principles, which are opposed to each other, and at the same time, unite, create each other conditions for existence, within one phenomenon. The notions of IN and YN express the duality of all natural phenomena: rhythm and chaos, energy and matter, day and night, light and darkness, motion and peace, top and bottom, heat and cold. The normal state of the human body, in relation to the physiological balance, is maintained through the change of opposites IN and YN (the change of the phases of active labor and sleep, the transference of mental and physical activity). If the interaction of opposites is destroyed as a result of the completeness or insufficiency of the INN or the YN relative to the physiological balance of the organism, there may be a disease.
Strategy of insomnia treatment in patients with chronic cerebral ischemia and comorbid pathology
Authors: Sulik R.V. , Klymenko O.V. , Yavorska A.V. , Kovbasyuk Y.V. , Klymenko L.V.
Published: February 2019

The article presents the results of rofen drug study effectiveness in the treatment of patients with chronic cerebral ischemia with insomnia. The characteristic of vegetative and objective complaints regressions in patients during the treatment is presented. The effectiveness of different treatment regimens is evaluated depending on the duration of anxiety-depressive disorders and autonomic dysfunction. The influence of the duration of insomnia, comorbidity, anxiety-depressive disorders on the choice of therapeutic tactics in this patient has been analyzed.
Back Pain Treatment: A Review of the 2018 Recommendations
Authors: Svyrydova N.
Published: February 2019

In 2018, published works that focus on European and American recommendations for the treatment of chronic back pain, where using opioid analgesics, it is recommended to take into account their complexity in multimorbid pathology in patients, since there is no effectiveness of pain reduction due to polypharmacotherapy. The peculiarity of the treatment is that the prevalence of musculoskeletal pain more often reaches its peak in elderly patients and is about 60%, which allows to establish an important direction in therapy - taking into account multimorbid pathology. It is necessary to take into account the accompanying chronic pathology because in patients with back pain hypertension occurs in 58.7%, chronic kidney disease occurs in 29.1% of patients, diabetes mellitus occurs in 23.1% of patients, depressive disorders occur in 15 , 3% of patients. Today it is proved that the common use of NSAIDs is critical for adverse events on the part of their use in patients with multimorbid pathology. In a number of clinical studies, the significant effect of tolperisone has been proven to relieve muscular spasm in acute and chronic back pain compared to tizanidine, where tolperisone is more often used in multimorbid pathology as a relaxant of skeletal muscles. The combination therapy strategy potentially represents a paradigm shift in rehabilitation therapy and can be very important for early intervention in spasticity management processes. In order to expand the scope of potential therapeutic use, the basic requirement for safe treatment is the quantitative basis of evidence of safety and efficacy, which, for example, is now presented in full on tolperisone hydrochloride. The new therapeutic options include a progressive addition of convergent therapy, where it is assumed that the potential for therapeutic purposes will be strengthened in view of the multimorbid pathology in the patient with back pain.
Differential diagnosis of Parkinson Disease and Corticobasal Degeneration (disease course and progression)
Authors: Trufanov Y.
Published: February 2019

The objective of our research was the description of the differential diagnostic features of Corticobasal Degeneration and Parkinson Disease in order to improve the diagnosis and the differential diagnosis of these diseases. Corticobasal Degeneration was characterized by marked asymmetry of motor symptoms, malignant progression and the lack of therapeutic effect of dopaminergic medications. Parkinson Disease was characterized by an asymmetry of motor symptoms, benign progression and efficacy of dopaminergic medications.
Multiple sclerosis: clinical and pathogenetic characteristics and therapeutic approaches based on comorbidity
Authors: Chupryna G.
Published: February 2019

The research is dedicated to studying the clinical, neurophysiological, neuroimaging, neuropsychological, immunopathological manifestations of MS on the background of comorbid pathology, evaluation of complex treatment.The features of the manifestations of fatigue, depression, pain, cognitive impairment, sleep disorders in patients with MS based on comorbidity and impact of violations on the quality of life.

On the basis of the study of risk factors, the analysis revealed the features of development of MS in conditions of comorbid pathology. Based on the factors studied, a pathogenetic model of the character of the effect of comorbidity on the course of MS with regard to prognostic signs for clinical, psychoemotional, neurophysiological and neuroimaging indicators has been created, and it is possible to individually assess the risk of development and progression of MS. Efficacy and comparative analysis of the use of complex (medicaments and non-medicaments) treatment was revealed, the frequency of exacerbations decreased and the effect on the course of the disease with MS taking into account the comorbid pathology and heterogeneity of clinical-neurological and psychoemotional disorders, clinical, neuropsychological, neuroimaging, neuroimaging signs of disease activity.
Clinical Case: Condition of the patient after repeated acute cerebrovascular disruption by ischemic type in the basin of the right middle cerebral artery with left-sided hemiparesis
Authors: Svyrydova N. , Ingula N. , Bieliakova І. , Ruda N. , Pidgirna K. , Shcherbaty A.
Published: February 2019

Cardiovascular diseases (CVD) – represent between 30 percent to 50 percent of all cardiovascular system’s diseases, and account 110 thousands of new stroke cases every year in Ukraine, death rate during first 30 days is 30-40 % and 50 % during 1st year. Primary stroke morbidity is higher in 1.5-2 times than world’s average. The most significant risk factors of stroke are hypertension, heart diseases (coronary artery disease, heart rhythm disorders), transient ischemic attack in anamnesis, diabetes, atherosclerosis (dyslipidemia). According conducted researches it is proven, that level of systolic blood pressure correlates with decreased risk of stroke in patients with hypertension. This article describes a case from clinical practice – management of patient with acute ischemic stroke. The attention is focused on the methods of examination, basic treatment strategy and rehabilitation of patient with this pathology.
INTERVENSI KESEHATAN PADA PENURUNAN DEPRESI LANSIA: REVIEW ARTIKEL
Authors: Afni Erina Nur , Nugraheni Sri Achadi
Published: February 2019

Pertumbuhan 20-25% prevalensi gangguan kejiwaan di Iran dibandingkan dengan 21,5% pada tahun 2012 (1) kerusakan pada kesehatan, kebahagiaan, kemampuan untuk melakukan aktivitas kehidupan sehari-hari (2) dan menyebabkan 50% gangguan psikosomatis. Sehingga 30% orang yang dirujuk ke pusat kesehatan menderita masalah psiko-sosio-spiritual (1). Dimasukkannya dimensi kesehatan spiritual ke dalam konsep kesehatan, memperkenalkan dimensi penting, untuk ahli kesehatan (3). “Deklarasi Kopenhagen tentang Pembangunan Sosial” dan “Piagam Bangkok” menekankan dimensi spiritual untuk promosi kesehatan baru-baru ini (4). "Dewan Perawat Internasional" menemukan peran perawat dalam mempromosikan suasana di mana hak asasi manusia, nilai-nilai, kebiasaan, dan kepercayaan spiritual orang, keluarga, dan masyarakat dihormati.
DETERMINAN KEJADIAN TB PARU
Authors: Yetiani Novin
Published: February 2019

Tuberkulosis adalah suatu penyakit menular yang sebagian besar disebabkan oleh kuman mycobacterium tuberculosis. penderita Tuberkulosis Paru dengan BTA (+) di Puskesmas Tanjung Puri yaitu, pada tahun 2014 terdapat 30 pasien, tahun 2015 terdapat 25 pasien, dan tahun 2016 terdapat 35 pasien namun 15 orang diantaranya sudah dinyatakan sembuh sehingga sisa 20 orang pasien.Tujuan dari penelitian ini adalah untuk mengetahui Determinan yang berhubungan dengan kejadian TB Paru. Jenis penelitian ini adalah penelitian kuantitatif dengan jenis penelitian Case Control. Total populasi sebanyak 60 responden dengan jumlah kasus sebanyak 20 orang dan kontrol adalah orang yang mempunyai kriteria yang sama dengan kasus sebanyak 40 orang. Sampel diambil dengan teknik purposive sampling. Analisis data menggunakan software statistik dengan taraf signifikan 0,05. Hasil uji statistik diketahui tidak ada hubungan pekerjaan dengan kejadian TB Paru (P=1,000), ada hubungan pengetahuan dengan kejadian TB Paru (P=0,022 dan OR= 4,500), ada hubungan sikap dengan kejadian TB Paru (p=6,000), ada hubungan Lingkungan dengan kejadian TB Paru (P=3,889). Disarankan kepada petugas kesehatan dapat memberikan penyuluhan dan kepada masyarakat dapat menerapkan perillaku hidup bersih dan sehat.
Rembrandt's Windmill: Edinburgh International Festival Diary 2018
Authors: Relich Mario
Published: February 2019

A review of the Edinburgh Festivals in 2018. The underlying theme of ‘the best of times, the worst of times’ is unpacked.
γ-Propoxy-Sulfo-Lichenan Induces In Vitro Cell Differentiation of Human Keratinocytes
Authors: Esch Stefan , Gottesmann Maren , Hensel Andreas
Published: February 2019

Background: As non-cellulosic β-d-glucans are known to exert wound-healing activity by triggering keratinocytes into cellular differentiation, the functionality of a semisynthetic lichenan-based polysaccharide on skin cell physiology was investigated. Methods: γ-Propoxy-sulfo-lichenan (γ-PSL, molecular weight 52 kDa, β-1,3/1,4-p-d-Glucose, degree of substitution 0.7) was prepared from lichenan. Differentiation of primary human keratinocytes was assayed by the protein analysis of differentiation specific markers and by gene expression analysis (qPCR). The gene array gave insight into the cell signaling induced by the polysaccharide. Results: γ-PSL (1 to 100 μg/mL) triggered keratinocytes, in a concentration-dependent manner, into the terminal differentiation, as shown by the increased protein expression of cytokeratin 1 (KRT1). Time-dependent gene expression analysis proved differentiation-inducing effects, indicating strong and fast KRT1 gene expression, while KRT10 expression showed a maximum after 12 to 24 h, followed by downregulation to the basal level. Involucrin gene expression was only changed to a minor extent, which was similar to loricrin and transglutaminase. Gene array indicated the influence of γ-PSL on MAP kinase and TGF-β mediated signaling towards keratinocyte differentiation. Conclusion: The propoxylated lichenan may improve wound healing by topical application to promote the terminal barrier formation of keratinocytes.
RESEARCH INTO SAFE TRAFFIC OF LITHUANIAN RAILWAY LINES
Authors: Černiauskaite Laura , Podagelis Igoris , Sakalauskas Kazys
Published: February 2019

The European Union directions pay a specific focus on traffic safety. Safety of railway transport traffic is among priority fields which has a direct effect on the quality of life of the population. It is most convenient to consider the number of breaks and accidents per year as the indicator of traffic safety. Reasons of traffic accidents can be very different. Most accidents occur due to poor technical condition of rolling‐stock and infrastructure, the human factor and the deficient organization of traffic. Stock Company “Lithuanian railways” can not assure safe traffic yet. The number of traffic incidents decreased in a few preserves only. Considering that, it is necessary to prepare a strategy for traffic safety and the program for its implementation. In 2002 specialists started preparing a study for safe traffic. The study is important for the preparation and implementation of the mentioned program. First results obtained from the research have already approved the importance of the influence of infrastructure, rolling‐stock and a human factor on traffic safety. The research carried out indicates positive changes in the situation of traffic safety of Lithuanian railways.
A DECISION SUPPORT MODEL FOR CIVIL ENGINEERING PROJECTS BASED ON MULTI-CRITERIA AND VARIOUS DATA
Authors: Issa Usama H. , Miky Yehia H. , Abdel-Malak Fam F.
Published: February 2019

This paper develops a model, introduced in software, namely Multi-Criteria Decision-Making Model (MCDMM). The model helps decision makers selecting the most suitable alternative based on the customer requirements and preferences. Analytic Hierarchy Process (AHP) and Fuzzy Technique for Order of Preference by Similarity to Ideal Solution (Fuzzy TOPSIS) form a package that covers most available data types in construction projects. In MCDMM, AHP produces criteria relative weights according to their influence on the discussed problem, while Fuzzy TOPSIS is applied to rank the available alternatives. The model consists of two modules, first one uses AHP only to deal with precise, qualitative alongside quantitative data, while the other module combines AHP with Fuzzy TOPSIS due to the importance of linguistic variables to cover undocumented data. MCDMM is verified using two real case studies. The model is applied to a real case project for constructing solar power plants at Saudi Arabia. A decision required to select the most suitable surveying technique for producing Digital Terrain Model (DTM) among four alternatives (Total Station, Remote Sensing, Photogrammetry, and Global Positioning Systems). This issue is studied and key points are identified for prioritizing among them. Total Station is selected based on the model results.
The Sunyaev–Zel’dovich Effect of Simulated Jet-inflated Bubbles in Clusters
Authors: Ehlert Kristian , Pfrommer Christoph , Weinberger Rainer , Pakmor Rüdiger , Springel Volker
Published: February 2019

Feedback by active galactic nuclei (AGNs) is essential for regulating the fast radiative cooling of low-entropy gas at the centers of galaxy clusters and for reducing star formation rates of central ellipticals. The details of self-regulation depend critically on the unknown contents of AGN-inflated bubbles. Observations of the Sunyaev–Zeldovich (SZ) signal of AGN bubbles provide us with the ability to directly measure the lobe electron pressure given a bubble morphology. Here we compute the SZ signal of jet-inflated bubbles in three-dimensional magnetohydrodynamical simulations of the galaxy cluster MS0735.6+7421 with the Arepo code, and compare our synthetic SZ results to inferences obtained with popular modeling approaches. We find that cutting out ellipsoidal bubbles from a double-beta pressure profile only matches the inner bubble edges in the simulations and fails to account for the emission of the shock-enhanced pressure cocoon outside the bubbles. This additional contribution significantly worsens the accuracy of the cut-out method for jets with small inclinations with respect to the line of sight. Also, the kinetic SZ effect of the bubbles, a previously neglected contribution, becomes relevant at these smaller inclinations due to entrainment and mixing of the intracluster medium with low-density jet material. Fortunately, the different signs of the kinetic SZ signal in opposite lobes allow this effect to be modeled. We present an approximate method to determine the jet inclination, which combines jet power and lifetime estimates, the stand-off distance between jet head and bow shock, and the kinetic SZ effect, thereby helping to correctly infer the bubble contents.
Explaining the Early Excess Emission of the Type Ia Supernova 2018oh by the Interaction of the Ejecta with Disk-originated Matter
Authors: Levanon Naveh , Soker Noam
Published: February 2019

We explain the early excess emission of the Type Ia supernova 2018oh by an interaction of the supernova ejecta with disk-originated matter (DOM). Such DOM can form in the merger process of two white dwarfs in the double-degenerate scenario of Type Ia supernovae (SNe Ia). We find that an ejecta-DOM interaction can fit the early light curve of SN 2018oh better than an ejecta-companion interaction in the single-degenerate scenario. By composing the DOM from two components that were ejected in the merger process with two different velocities, we show that the ejecta-DOM interaction can account for the linear rise in the light curve, while the ejecta-companion interaction predicts too steep of a rise. In addition, the ejecta-DOM interaction does not predict the presence of hydrogen and helium lines in nebular spectra, and hence does not suffer from this major drawback of the ejecta-companion model. We consider the ejecta-DOM interaction to be the most likely explanation for the early excess emission in SN 2018oh. By that we show that the double-degenerate scenario can account for early excess emission in SNe Ia.
New information about the pre-imaginal morphology of genus Graptomyza (Diptera, Syrphidae, Volucellini): description of third-instar larva and re-description of puparium of G. signata (Walker, 1860)
Authors: Aracil Andrea , Pérez-Bañón Celeste , Mengual Ximo , Radenković Snežana , Ståhls Gunilla , Vujić Ante , Rojo Santos
Published: February 2019

Pre-imaginal morphology of the flower fly species Graptomyzasignata (Walker) is described and figured in detail based on specimens collected on a decomposed Aloe-like plant in KwaZulu-Natal province, South Africa. Third-instar larva is described for the first time and the puparium morphology is re-described using both light (optical) and electron microscopy. The present work represents the second larval description for a species of the genus Graptomyza, after the description of the larva of G.alabeta Séguy. The immatures of these two Graptomyza species were examined and compared to the pre-imaginal stages of the other members of the tribe Volucellini, pointing out the possible diagnostic characters of the genus Graptomyza. Moreover, new DNA barcodes are provided for G.signata and deposited in the NCBI GenBank.