bluuebunny/crossref_metadata_2025 huggingface dataset:
How to predict the density of liquids up to the Gigapascal range knowing only data obtained at ambient pressure: the Tait equation meets the phonon theory of liquids
Authors: Postnikov Eugene B. , Belenkov Roman N. , Chorążewski Mirosław
Published: February 2023

Predicting the density of liquids at ultrahigh pressures in the case when only the data measured at ambient pressure are available is a long-standing challenge for thermodynamic research. In this work, we archived this goal for molecular liquids by applying the half-sum of the Tait equation and the Murnagnan equation in the form coordinated with Tait’s at low pressure for predicting the density of molecular liquids up to the pressures more than 1 GPa with uncertainty comparable with the experimental one. It is shown that the control parameter, which is needed in addition to the initial density and the isothermal compressibility can be found using the speed of sound and the density at ambient pressure and has a clear physical interpretation in terms of the characteristic frequency of intermolecular oscillation mimicking the limiting frequency of Debye’s theory of heat conductivity of solids. This fact is discussed as arguing in favour of the modern phonon theory of liquid thermodynamics and expands it range of applicability to the volumetric properties of liquids at temperatures far below the critical one. The validity of the model is illustrated with the case study of classic Bridgman’s dataset as well as with some examples of ultrahigh-pressure data obtained by the diamond anvil cell and shock wave compression methods.
Quantum chemical investigations on a supramolecular porphyrin-fulleropyrrolidine dyads for photovoltaic devices
Authors: Bhattacharya Shalmali , Saha Shiv Sankar , Chatterjee Soumya , bhattacharya sumanta
Published: February 2023

The present paper deals with the estimation of conformational stability and determination of electronic structures of H2-porphyrin-fulleropyrrolidine (1) and zincporphyrin–fulleropyrrolidine (2) dyads by ab initio (HF)and density functional theory (DFT) calculations in vacuo. In dyads 1 and 2, fulleropyrrolidine is directly linked to the tetrapyrrolic rings by ethylene subunits. Both HF and DFT calculations establish that possibility of photoinduced electron transfer (PET) phenomenon is higher in case of 2 compared to 1. Investigation on frontier molecular orbitals at different electronic states reveal that the highest occupied molecular orbital and the lowest unoccupied molecular orbital of these supramolecules is delocalized due to PET phenomenon. Generation of molecular electrostatic potential (MEP) maps by both HF and DFT calculations substantiate the PET phenomenon (as stated above) and establish that the direction of electron transfer occurs from the porphyrin subunits to the fulleropyrrolidine in dyads 1 and 2.
Physiotherapy Students’ Expectations of Their First Clinical Internship: A Qualitative Study.
Authors: Mestres-Soler Olga , Marques-Sole Elena , Granel Nina , Arnal-Gómez Anna , Tolsada-Velasco Catalina , Hernández-Guillén David , Gómez-Ibáñez Rebeca
Published: February 2023

Background. Physiotherapy students’ expectations of their first clinical education year can be over- or under-estimated. Expectations are related to motivational aspects of behaviour as well as satisfaction, so they may have some influence on academic performance.
Objective. The aim of this study is to describe physiotherapy students’ expectations related to their first clinical internship.
Methods. Qualitative, exploratory study. Participants included physiotherapy students prior to initiating their first clinical internship. Data were collected through semi-structured interviews. The data were analysed using thematic analysis, as proposed by Braun and Clarke. The study protocol was approved by the University of Valencia Ethics Committee of Human Research.
Results. This study included 12 students (six being women; average age 24.2±8.4 years), which was sufficient to reach data saturation. We identified 12 subcategories within five categories: i) perceived meaning of practical training, ii) reference figure during clinical internship, iii) Emotions felt in the first practical training sessions, iv) the easiest and most difficult part of practical training sessions, and v) clinical placement selection factors.
Conclusions. The study has provided detailed explanation of the students’ perceived meaning of the practical training being demonstrated that students gave a real significance to the clinical internship. Positive and negative emotions were present combined with a great enthusiasm to achieve their positives expectations. There was a substantial alignment between expectations of physiotherapy students before their first clinical internshipand the reality, which had a positive impact on their practical learning.
PRMT5 Promotes Esophageal Carcinoma Metastasis by Enhancing PAK1 Phosphorylation
Authors: Wu Guowu , Zou Xiaofang , Lin Yiwen , Meng Yuhua , Chen Shuanglong , Gu Yinfang , Guo Longhua , Yi Lilan , Dong Hongmei , Wang Lu , Zhang Dianzheng , Zhang Hao
Published: February 2023

Background
Protein arginine methyltransferase 5 (PRMT5), a member of protein arginine methyltransferases, is an enzyme catalyzing the methylation of arginine residuals of histones and non-histone proteins to serve as one of many critical posttranslational modifications (PTMs). Phosphorylated P21-activated kinase 1 (p-PAK1), a member of serine/threonine protein kinases family, is a cytoskeletal protein playing a critical role in metastasis. This study aimed to explore the potential therapeutic value of PRMT5 and p-PAK1 in esophageal squamous cell carcinoma (ESCC).
Methods and results
PRMT5 expression in 106 primary human ESCC tissues with their adjacent non-cancerous tissues was detected by immunohistochemistry (IHC). Cell migration was detected by wound healing assays. Finally, we evaluated the clinical significance of PRMT5 combined with PAK1 and p-PAK1 by IHC staining. PRMT5 is upregulated in ESCC and the level of PRMT5 is not only correlated with metastasis but also can serve as an independent prognostic factor for overall survival (OS). PRMT5 knockdown remarkably inhibited ESCC cell migration with concomitantly reduced levels of phosphorylated PAK1 (p-PAK1). IHC assay of human ESCC tissue revealed that the levels of PRMT5 are highly correlated with that of p-PAK1. Kaplan-Meier analysis showed that the OS of patients with PRMT5high/p-PAK1high are significantly shorter than the others (PRMT5high/p-PAK1low, PRMT5low/p-PAK1low, and PRMT5low/p-PAK1high).
Conclusions
Targeting the PRMT5-p-PAK1 axis is of potential values in ESCC stratification and treatment.
Prediction of texture on two cultivars’ table grapes based on weight loss during ambient storage
Authors: Cheng Xiaoyan , Bai Yuhe , Oyom William , Wu Yuanling , Bi Yang , Zhao Youyi
Published: February 2023

Texture is an important indicator to evaluate the quality of table grapes. However, there is no convenient and fast method to estimate the texture on grapes. Hence, this study evaluated the texture of two table grapes (cvs. Red Globe and Wink) through weight loss-dependent modeling under ambient storage. The weight loss and textural properties of the Polynomial, Boltzmann, and ExpDec2 models were found to better fit the obtained data. The equations were proved to be more efficient in describing the change in weight loss and texture of 'Red Globe' and 'Wink', with the best equations fitted to the weight loss and textural parameters having an average mean standard error of 3.78%. The feasibility of the established models was evaluated, and parametric confidence intervals of the equations were proposed to fit the different varieties of grapes. According to our findings, the textural quality of table grapes can be predicted by weight loss. The results may offer a critically convenient and fast method to estimate the texture on grapes for industry.
Preparation of C-terminal epitope imprinted particles for recognition of cytochrome c assisted with γ-cyclodextrin by host-guest interaction
Authors: Ji Wenquan , Wang Yongjian , Zhang Hongfeng , Zhao Jin , Li Qinran , Deng Qiliang , Sun Donglan , Liu Tianjun
Published: February 2023

A kind of epitope surface imprinted particles was synthesized to selective recognize cytochrome c (Cyt c) by a novel strategy assisted with γ-cyclodextrin (γ-CD) by host-guest interaction. C-terminal epitope nonapeptide of Cyt c was chosen as the template. γ-CD was immobilized on the surface of the silica as an encapsulated molecule to capture the template and improve the corresponding spatial orientation by the host-guest interaction in the recognition of the imprinted materials for the peptide and target protein. After γ-CD and the epitope modified, the surface imprinted polymer assisted with the host-guest interaction was synthesized with monomers and cross-linkers by radical polymerization strategy. The epitope surface imprinted particles were obtained after the peptide removed. The imprinted polymers prepared with the optimized condition achieved the best binding capability, 2.89 mg·g-1 AE-9 with the IF=4.07 and 37.58 mg·g-1 Cyt c with the IF=3.38. The efficiency and selectivity for protein recognition were also satisfactory. Additionally, the imprinted particles assisting by γ-CD have good reusability with 89.89% of the original after five sorption-elution cycles and showed significantly better recognized ability (IF=3.38) than those without γ-CD assisting (IF=1.44). Furthermore, the performance of Cyt c recognition in bovine serum sample by the imprinted polymers was calculated by HPLC. These results indicated that this epitope imprinted method assisted with the host-guest recognition interaction by γ-CD exhibited well specific recognition abilities towards the target protein Cyt c and potential application for Cyt c recognition in biological sample.
High-Performance Liquid Chromatography (HPLC) Method Validation for Simultaneous Quantitation of Five Phytoestrogenic Flavonoids
Authors: Cruz John Carlo dela , Quiming Noel , Nicolas Marilou , Velarde Michael , Mae Marquez Cielo
Published: February 2023

A Reversed Phase High Performance Liquid Chromatography (RP-HPLC) method for simultaneous quantitation of four isoflavone standards daidzein, genistein, formononetin and biochanin A, and one flavone standard quercetin was developed and validated through the evaluation of linearity, accuracy, precision, specificity, limit of detection and limit of quantitation in accordance with the ICH guidelines. The analysis was performed in a C18 column (150 x 4.6mm, 5µm) with an optimised gradient elution using acetonitrile-water (0.1% trifluoroacetic acid) at a flow rate of 1.0mL min-1 and sample injection volume of 10uL.The retention times of the standards in the order daidzein, quercetin, genistein, formononetin and biochanin A were 4.42, 5.24, 7.85, 10.06 and 13.55 minutes, respectively with tailing factors ranging from 1.09 – 1.12 and minimum resolution value of 3.74. Detection limits range from 0.339 to 0.964 ug/mL and quantitation limits range from 1.027 to 2.922 ug/mL with good linearity (R2 ≥ 0.9967) with a linear range of 1.25 - 20ug/mL for all standards. The method was also found to be accurate and precise based on percentage recovery ranging from 96.96% to 106.87% (intraday, n=3) and relative standard deviation of %RSD≤1.45% (intra-day, n=3) and %RSD≤2.35% (inter-day, n=5). The specificity of the method was evaluated based on the positivity of the minimum peak purity index during the quantitation of the target compounds from the spiked hydrolysed and unhydrolyzed extract of Cajanus cajan ICPL 7035.
Improved Social Network Search based Twin Extreme Learning Machine
Authors: Yang Yang , Xue Zhenxia , Ma Jun , Chang Xia , Xu Changlin
Published: February 2023

An excellent classifier termed as twin extreme learning machine (TELM) has been widely used in semantic classification, medical image recognition and other fields. However, due to the random weights and biases are generated in the feature space of TELM, there will be some non-optimal or unnecessary weights and biases, which will reduce the efficiency of the TELM and increase the testing cost. In this paper, we first propose a novel metaheuristic algorithm called improved social network search (ISNS) to solve optimization problems. ISNS introduces logistic chaotic mapping and adds a reverse learning strategy of lens principle on the Social Network Search (SNS), which can accelerate the convergence of SNS. Then, in order to optimize the weights and biases of TELM we propose an improved social network search based twin extreme learning machine algorithm (ISNS-TELM), which can improve TELM performance effectively. Finally a number of mathematical functions were chosen to evaluate the performance of our ISNS algorithm. Furthermore, we compare our ISNS-TELM with some state-of-the-art algorithms on the UCI dataset and several multi-category imagine dataset. According to the experiment results, the ISNS-TELM is capable of achieving better training results and getting faster convergence speed.
Use of electrical resistivity tomography to detect loose ground near an excavation site in an area of urban ground subsidence in South Korea
Authors: Song Seo Young , Kim Bitnarae , Cho Ahyun , Jeong Juyeon , Lee Dongkweon , Nam Myung Jin
Published: February 2023

Ground subsidence in urban areas due to excessive development and degraded underground facilities is a serious problem. Geophysical surveys have been conducted to estimate the distribution and scale of cavities and subsidence. In this study, electrical resistivity tomography (ERT) was performed near an area of road subsidence in an urban area. The subsidence arose due to groundwater leakage that carried soil into a neighboring excavation site. The ERT survey line was located between the main subsidence area and an excavation site. Because ERT data are affected by rapid topographic changes and surrounding structures, the influence of the excavation site on the data was analyzed through field-scale numerical modeling. The effect of an excavation should be considered when interpreting ERT data because it can lead to wrong anomalous results. A method for performing 2D inversion after correcting resistivity data for the effect of the excavation site was proposed. This method was initially tested using a field-scale numerical model that included the excavation site and subsurface anomaly, which was a loosened zone, and was then applied to field data. In addition, ERT data were interpreted using an existing in-house 3D algorithm, which considered the effect of excavation sites. The inversion results demonstrated that conductive anomalies in the loosened zone were greater compared to the inversion that did not consider the effects of excavation.
Open-field and pot studies on application of ancient liquid organic manures for the growth and development of tomato (Solanum lycopersicum)
Authors: Rijal Robin , Kumar Adesh , Bhetwal Sugam
Published: February 2023

In the study, liquid manures (panchgavya and jeevamruth) having concentrations 0% (control), 1%, 2%, 3%, 4%, 5% and 6% were prepared by using the products obtained from indigenous cow and then applied in three different formats twice a month up to 3 months in both fields and pot plants. In the first format, panchgavya was applied directly to the root zone. In the second format, jeevamruth was also applied to the root zone. Likewise, in the third format, panchgavya was sprayed uniformly on the foliage, but jeevamruth was given to the root zone of the same plant with irrigating water. After that, growth and development parameters of plants were taken precisely at 30, 45, 75, 90 and 105 days after transplantation, and found that significant differences were noticed in terms of growth, flowering and fruiting between pots and field plants. It was noted that these parameters were superior in those plants that were grown in the field than that of pots plants at 5% and 6% in all three different combinations. Among three formats, the combined application of panchgavya and jeevamruth was found to have magnificent results, followed by solely applications of panchgavya and jeevamruth. The study aimed to evaluate and compare the beneficial effect of panchgavya and jeevamruth in organic agriculture by using different formats in both pots and the field environment.
An assessment of viscoelastic finite-difference models applied to the Brazilian pre-salt
Authors: Augusto Fabrício O. A. , Moreira Roger M. , Cetale Marco , Tostes Danielle M. , Filho Djalma M. Soares
Published: February 2023

Viscoelastic waves are modeled using a 3D time-domain finite-difference scheme with three classical rheological models – Maxwell (M), Kelvin-Voigt (KV), Standard Linear Solid (SLS) – each of them with a single relaxation mechanism. Attenuation and dispersion effects are introduced in terms of the quality factor \textit{Q} for a certain angular frequency $\omega$. Initially, seismic attenuation of the 2D poststack seismic data from Brazilian pre-salt is evaluated through a frequency analysis. After that, numerical results are validated with analytical solutions based on a homogeneous model with constant seismic properties. The behavior of each rheological model are discussed based on phase, wave amplitude and spectrum. A simplified multilayered geological model is proposed considering regions of the poststack seismic data from the Brazilian pre-salt, Búzios field. Synthetic data are then generated for each rheological model considering two approaches in terms of \textit{Q} distribution: a constant \textit{Q} and a varying \textit{Q} per layer. Both waveform and spectra are extracted from seismograms and compared with selected regions of Búzios poststack data. The amplitude spectra confirmed that the shallowest post-salt package is more dissipative than deeper regions. Moreover, based on the analysis of synthetic data, KV and SLS models proved to be effective to mimic seismic wave propagation at Búzios field. Synthetic results also show that a \textit{Q} distribution per layer can yield a seismic attenuation behavior similar to the one observed within the data.
Oxidized dietary lipids induce vascular inflammation and atherogenesis in post- menopausal rats: Estradiol and selected antihyperlipidemic drugs restore vascular health in vivo
Authors: Folahan Joy , Olorundare Olufunke Esan , Ajayi Abayomi Mayowa , Oyewopo Adeoye Oyetunji , Soyemi Sunday Sokunle , Adeneye Adejuwon Adewale , Okoye Ikechukwu Innocent , Afolabi Saheed Olanrewaju , Njan Anoka Ayembe
Published: February 2023

Background
Thermoxidation of edible oil through deep fat frying results in the generation of several oxidized products that promote lipid peroxidation and ROS production when eaten. Consumption of thermoxidized oil coupled with estrogen withdrawal contributes to the sudden development of vascular diseases in post-menopausal women. This study evaluates the role of estradiol and antihyperlipidemic agents (AHD) in restoring the vascular health of ovariectomized (OVX) rats fed with thermoxidized palm oil (TPO) and thermoxidized soya oil (TSO) diets.
Method
A total of 10 groups of rats (n = 6) were set up for the experiment. Group I (normal control) rats were sham handled while other groups were OVX to bring about estrogen deficient post-menopausal state. Group II (OVX only) was not treated and received normal rat chow. Groups III-X were fed with either TPO or TSO diet for 12 weeks and treated with estradiol (ETD) 0.2 mg/kg/day, atorvastatin (ATV) 10 mg/kg/day, and a fixed-dose combination of ezetimibe and ATV (EZE 3 mg/kg/day + ATV 10 mg/kg/day).
Results
Pro-atherogenic lipids levels were significantly elevated in untreated TSO and TPO groups compared to OVX and sham, resulting in increased atherogenic and Coronary-risk indices. Treatment with Estradiol and AHDs significantly reduced the total cholesterol, triglycerides, low-density lipoprotein cholesterol as well as AI and CRI compared to untreated TSO and TPO groups, whereas TSO and TPO groups showed significant elevation in these parameters compared to Group I values. Moreover, aortic TNF-α levels were extremely elevated in the untreated TSO and TPO compared to Group I. TNF-α levels were significantly reduced in rats treated with AHDs and ETD. Localized oxidative stress was indicated in the aortic tissues of TSO and TPO-fed OVX rats by increased malondialdehyde and decreased glutathione, catalase, and superoxide dismutase levels. This contributed to a depletion in aortic nitric oxide. AHDs and ETD replenished the nitric oxide levels significantly. Histological evaluation of the aorta of TSO and TPO rats revealed increased peri-adventitia fat, aortic medial hypertrophy, and aortic recanalization. These pathologic changes were less seen in AHDs and ETD rats.
Conclusion
This study suggests that ETD and AHDs profoundly attenuate oxidized lipid-induced vascular inflammation and atherogenesis through oxidative-stress reduction and inhibition of TNF-α signaling.
Clinical study of butyrylcholinesterase and heparin binding protein as early markers of traumatic inflammation
Authors: Zhang Huiying , Liu Hui , Wang Jianguo
Published: February 2023

Background To observe the changes of butyrylcholinesterase (BChE) and heparin binding protein (HBP) in post-traumatic inflammation, in order to determine whether they can be used as early diagnostic indicators of post-traumatic inflammation.
Methods Injury severity score (ISS) was used to evaluate the severity of trauma. The activity of butyrylcholinesterase in patients with traumatic injury with ISS ≤ 3 and ISS > 3 was detected, and the levels of related inflammatory biomarkers were detected. Sixty patients with trauma treated in our hospital from August 2022 to October 2022 were divided into control group (ISS ≤ 3) and damage group (ISS > 3) according to ISS. Another 30 cases of non-invasive physical examination in the same period were selected as the normal group. BChE, HBP, white blood cell count (WBCC) and C-reactive protein (CRP) were measured at T0, 1 h (T1), 2 h (T2), 3 h (T3), 4 h (T4) and 5 h (T5). The differences among the indexes were statistically analyzed.
Result The BChE of patients with ISS > 3 decreased significantly at 1 hour after admission, while the BChE of patients with ISS ≤ 3 had no significant change at 5 hours. The HBP of the patients with ISS > 3 increased significantly at 1 hour after admission, while the BChE of the patients with ISS ≤ 3 had no significant change at 5 hours. There was no significant change in CRP and WBCC at 5 h.
Conclusion The decrease of butyrylcholinesterase activity and the increase of heparin binding protein activity are the early indicators of acute systemic inflammation, which may be of great significance for the early diagnosis of traumatic systemic inflammation.
Trial registration This study was registered on http://www.chictr.org.cn/ with clinical trial registration number of ChiCTR 2200065884.
Pre-transplant Biomarkers of Immune Dysfunction Improve Risk Assessment of Post-transplant Mortality Compared With Conventional Clinical Risk Scores
Authors: Medina-Morales J. Esli , Panayotova Guergana G. , Nguyen Duc T. , Graviss Edward A. , Prakash Gagan S. , Marsh Jeffery A. , Simonishvili Sopio , Shah Yash , Ayorinde Tumininu , Qin Yong , Jin Lianhua , Zoumpou Theofano , Minze Laurie J. , Paterno Flavio , Amin Arpit , Riddle Grace Lee , Ghobrial R. Mark , Guarrera James V. , Lunsford Keri E.
Published: February 2023

Introduction: There is a critical need to accurately stratify liver transplant (LT) candidates' risk of post-LT mortality prior to LT to optimize patient selection and avoid futility. Here, we compare current pre-LT clinical risk scores with the recently developed Liver Immune Frailty Index (LIFI) for prediction of post-LT mortality. LIFI measures immune dysregulation based on pre-LT plasma HCV IgG, MMP3 and Fractalkine. LIFI accurately predicts post-LT mortality, with LIFI-low corresponding to 1.4% 1-year post-LT mortality compared with 58.3% for LIFI-high (C-statistic=0.85).
Methods: LIFI was compared to MELD, MELD-Na, MELD 3.0, D-MELD, MELD-GRAIL, MELD-GRAIL-Na, UCLA-FRS, BAR, SOFT, P-SOFT, and LDRI scores on 289 listed patients (T0). Survival, hazard of early post-LT death, and discrimination power (C-statistic) were assessed (Stata v17).
Results: LIFI showed superior discrimination (highest C-statistic) of post-LT mortality when compared to all other risk scores, irrespective of biologic MELD. On univariate analysis, the LIFI showed a significant correlation with mortality at 3- and 6-months, as well as 1-, 3-, and 5-years. No other pre-LT scoring system significantly correlated with post-LT mortality. On bivariate adjusted analysis, African American race and pre-LT cardiovascular disease were significantly associated with early- and long-term post-LT mortality (p<0.05). Patients who died within 1-yr following LT had a significantly higher incidence of infections, including 30-day and 90-day incidence of any infection, pneumonia, abdominal infections, and UTI (p<0.05).
Conclusions: LIFI, which measures pre-LT biomarkers of immune dysfunction, more accurately predicts risk of post-LT futility compared with current clinical predictive models. Pre-LT assessment of immune dysregulation may be critical in predicting mortality after LT and may optimize selection of candidates with lowest risk of futile outcomes.
Assessing the Effect of Work-Life Balance Initiatives on Organizational Citizenship Behaviour
Authors: Seman Abdilkerim Asrar , Ahmed Hamed M. S. , Refera Matewos Kebede , Amde Shemila Jemal , Thomran Murad , Ahmed Yimer Ayalew
Published: February 2023

The concept of work-life balance developed on the premise that career and personal life should not be seen as competing concerns but as balanced components of one’s overall existence. Initiatives to promote work-life balance become mandatory requirements for employees to maximize productivity and retain talent. This study examines the effect of work-life balance initiatives on organizational citizenship behavior in the case of commercial bank branches in Werabe (Ethiopia). Descriptive and explanatory research designs were employed by using a quantitative research approach. The data was collected through a standard questionnaire. The study used the census method. 150 employees from nine different commercial bank branches in Worabe town were selected to provide the study’s primary data. The collected data were analyzed using descriptive and inferential statistical tools. The study found that most employees’ perceptions were low for all significant work-life balance initiative variables included in this study; they were also medium in perceiving organizational citizenship behavior. Among the independent variables under investigation, three of them (flexible work arrangements, work leave programs, and dependent care initiatives) have positive and significant effects on organizational citizenship behavior. In contrast, the other two (working hours and workload) negatively and significantly affect organizational citizenship behavior. The beta coefficients of this study indicated that flexible work arrangements have a high effect on organizational citizenship behavior, followed by work leave programs. Therefore, it is better to adopt them in the organization. The influence of the abovementioned variables on organizational citizenship behavior is significant. This study fills this gap and extends the understanding of the role of variables. The bank’s management needs to offer initiatives by allowing employees to schedule their time and assisting and advising them on childcare costs and responsibilities such as schools, offering extended leave if something goes wrong, and sharing charges for education.
ISLAMIC BOARDING SCHOOL STUDENTS’ LEARNING STYLES IN EFL CLASS
Authors: Kalsum Kalsum
Published: February 2023

Abstract:

The students sometimes get confused with the English material because their learning style does not match with the presentation of the teacher. the learning styles need be known by teachers involved in teaching and learning process. This research aims to disclose students' needs for learning English based on their learning styles. This research used quantitative research with survey research methods. The research was conducted on second grade students of MA in three Islamic boarding schools in the city of Parepare, South Sulawesi, Indonesia. The instrument in this study is a questionnaire containing the Perceptual Learning Style Preferences Questionnaire consisting of Visual, Auditory. Kinesthetics, Tactile, Group and Individual Styles. This research discloses that students have more kinesthetics, auditory, visual, and group learning styles. It found that students’ learning styles are major in visual, auditory, kinesthetics, and group learning styles. Meanwhile, some of the students in Boarding School of Parepare are minor in tactile and individual learning styles. Therefore, the teacher should make teaching materials based on the learning style of each student.
THE CORRELATION BETWEEN THE FREQUENCY OF WATCHING BIMODAL SUBTITLED VIDEOS AND STUDENTS’ LISTENING COMPREHENSION
Authors: Febrina Millenia Berlian
Published: February 2023

Listening was a skill that language learners must have. In several studies, listening was an activity that was avoided by English learners due to various factors, but now students were used to practicing listening by watching English videos. This study was a correlational study that aimed to find out how was the correlation between the frequency of watching bimodal subtitled video and students’ listening comprehension as well as providing their perceptions toward the use of bimodal subtitled videos for listening practice. This study involved 36 students of 10th grade in Krian, East Java who had participated in a listening program to watch bimodal subtitled videos for two weeks at school. The collected data were analyzed statistically using SPSS 16. The results of the study reported that there was a significant positive correlation between students’ frequency of watching bimodal subtitled videos and their listening comprehension (r = 0.459, p = 0.05). Students also showed positive perceptions of the use of bimodal subtitled videos for listening practice. It could be concluded that students' frequency of watching bimodal subtitled videos was positively related to their listening comprehension and received good responses from them. Therefore, teachers could use bimodal subtitled videos for listening learning activity at school.
The Dual Mediating Effect of Meta-cognition Support Psychological Class Environment and Self-directed Learning Ability in the Relation between Creativity and Future Creative Confluence Competency
Authors:   Human Engagement Institute, Lee GaHyung , Jun JuSung , Lee KyungHwa
Published: February 2023

The purpose of this study was to examine the dual mediating effect of meta-cognition support psychological class environment(MSPCE) and self-directed learning ability (SOLA) in the relation between creativity and future creative confluence competency (F3C). Data were collected from 511 college students in Seoul, South Korea. PROCESS macro by Hayes (2013) was used to analyze the collected data. There are two major findings. First, positive correlations were noted among creativity, F3C, MSPCE, and SOLA Second, MSPCE and SOLA showed the partial dual mediating effect in the relation between the creativity and F3C of college students. The study results indicate that MSPCE must be established and an environment and education plan for enhancing SOLA should be developed to improve F3C, which is a key competency in future society.
DUFOURMENTAL FLAP RECONSTRUCTION, REVIEW AND MODIFICATIONS
Authors:   Department of Plastic Surgery SSH Hospital GMC Srinagar India 190001., Khurshid Junaid , Ahmad Bhat Bashir ,   Department of Plastic Surgery SSH Hospital GMC Srinagar India 190001.
Published: February 2023

Objective: The aim of this study is to present our clinical experience and suggest possible modifications of Dufourmental flaps. Materials and Methods: In our study thirty four patients operated for different pathologies with reconstruction done by Dufourmental flap July 2021 to December 2022. Results: Twenty-one of the 34 cases were male and the median patient age was 44.2 years. Nine cases were operated on under general anaesthesia and 25 were performed under local anaesthesia. In 20 cases the pathology was benign 10 cases the pathology was malignant and in rest four cases the defect was post-traumatic two among those were secondary to the dog bite. None of the patients has partial or total flap loss, one patient has margins positive on biopsy. Conclusion: Dufourmental flap although a local flap is very versatile flap and can be safely used in wide spectrum of defects and almost all areas of body. This flap can be easily tailored to meet the specific needs of the patient.
AGRICULTURAL MARKET INFORMATION GOVERNANCE: A CAPABILITY-ORIENTED NATIONAL FRAMEWORK FOR BENIN REPUBLIC
Authors:   Laboratory of Processes and Technological Innovations, National University of Sciences Technologies, Engineering andMathematics, Abomey, Benin., Abel Konnon Miton , Sobabe Ali Tahirou Abdou-Aziz ,   Laboratory of Electrotechnics, Telecommunications and Applied Computing, University of Abomey-Calavi, Benin., M. Moumouni Ismail ,   Laboratory of Research on Innovation for Agricultural Development, University of Parakou, Benin., Dieu-Donne Konnon M.F. ,   COTEF SARL, Cotonou, Benin.
Published: February 2023

Information technologies are improving the Agricultural Market Information delivery to the beneficiaries. The conceptualizationof the governance of disseminatedinformation, used by stakeholders to take important decisions, has become urgent.Therefore, the aim of this work is to design an Agricultural Market Information Governance Framework (AMIGov) focusing on governance capabilities of Benin.The designedcapability-oriented Agricultural MarketInformation Governance frameworkextends the existing Governance model of the Harmonized Information System ofAgricultural Markets of Benin. AMIGov is a three capability vertical layers framework with described practices to support each capability layer for achieving the Governance vision. The noveltyof AMIGovlies in the use of three main principles: (i) differentiation of governance and management functions and roles (ii) horizontal interactions between key stakeholders (co-governance of the Market Informationwith the involvement of the public and private sectors) (iii) compliance assessments at different levels across the country. Three key governance roles are suggested to improve the Governance practices: theNational Agricultural Market Information Leadership Group, the Information Governance Committee and the Information Governance Team. TheInformation Governance Team is theofficial operational workforce responsible for performance evaluation, and various compliance assessments(risk, regulatory, deployment, information quality).This team controls the actions of the Information Managerson the basis of predefined criteria and Service level Agreement, and reports to the Governance committee. The proposed framework can be recommended for use in the countries with a low level of digital organizational culture or where the MarketInformation Governance is not standardized.
EFFECTIVENESS OF PRE OPERATIVE TEACHING REGARDING LEG EXERCISES ON EARLY AMBULATION AMONG POST OPERATIVE PATIENTS UNDERGOING SELECTED ABDOMINAL SURGERIES IN THE SELECTED HOSPITAL, GANDHINAGAR
Authors:   Principal, Apollo Institute of Nursing, Gandhinagar (A Unit of Apollo Hospitals)., Mohan Singh Hari , Debnath Rinki ,   Associate Professor, Apollo Institute of Nursing, Gandhinagar (A Unit of Apollo Hospitals).
Published: February 2023

An experimental study was conducted to effectiveness of pre operative teaching regarding leg exercises on early ambulation among post operative patients undergoing selected abdominal surgeries in the selected hospital, Gandhinagar. The general system model was used as conceptual framework. A quantitative approach with experimental study design was used to achieve the objectives of the study. The sample consisted of 30 from selected areas of Gandhinagar. The random sampling technique was used to collect the sample. In the experimental group the mean early ambulation was 6.533 with standard deviation 0.80 and in the control group was 4.866 with SD 0.718. The calculatedt value was 7.376 where as table value is 1.69 in 0.05 level which shows highly significant. So, the pre operative leg teaching was highly effective in early ambulation during the post operative phase.
CLINICOPATHOLOGICAL SPECTRUM OF BENIGN ORAL CAVITY LESIONS
Authors:   Postgraduate, Department of Pathology, Rajarajeswari Medical College and Hospital, Kambipura, Mysore Road, Bengaluru-560074, India., Lokesh Prakruthi , P.S Sharmila ,   Professor, Department of Pathology, Rajarajeswari Medical College and Hospital, Kambipura, Mysore Road, Bengaluru-560074, India., D. Prabhu Shreya ,   Consultant Pathologist, PRIMA Diagnostics, Bengaluru, India., Maniyan Prakash Sumitha ,   Professor, Department of Pathology, Rajarajeswari Medical College and Hospital, Kambipura, Mysore Road, Bengaluru-560074, India., A. Raj Jyothi ,   Professor and Head of Department, Department of Pathology, Rajarajeswari Medical College and Hospital, Kambipura, Mysore Road, Bengaluru-560074, India., Kumar Soni Manish ,   Postgraduate, Department of Pathology, Rajarajeswari Medical College and Hospital, Kambipura, Mysore Road, Bengaluru-560074, India.
Published: February 2023

Background:Oral lesions can closely resemble one another and hence it is important for the clinicians to be able to recognize the various conditions and if possible obtain a biopsy for a confirmatory pathological diagnosis. Aim:To study the type of common benign lesions of the oral mucosa and to evaluate the concordance of clinical and histopathological diagnosis. Materials And Methods:A retrospective study was carried out in a tertiary care hospital in South Bangalore during the period of two years from June 2016 to May 2018. The study included 50 cases of benign lesions of the oral cavity. The following parameters were analyzed age and sex distribution of the lesion, site of the lesion, clinical presentation and histopathological diagnosis. Data collected were analyzed. Results:Among the 50 cases, the age ranged from 6 to 70 years with a mean of 30.3 years. Most of the patients were females (68%) in their 3rd decade. The sites of involvement of various lesions were labial mucosa with lower lip more commoner than upper lip, followed by tongue, buccal mucosa and maxillary alveolus. The various clinical diagnosis of the lesions were mucus retention cyst, papilloma and pyogenic granuloma. Excision biopsy of these lesions confirmed most cases of mucus retention cyst, pyogenic granuloma and few cases of papilloma on histopathological examination. Rest of the cases were extravastion cyst, fibromyxoma, actinomycosis, lobular capillary hemangioma, hamartoma, angiolymphoid hyperplasia with eosinophils and keratosis without atypia. Conclusion:Benign lesions of the oral cavity mimic each other. Histopathological typing of the lesions is mandatory to rule out malignancy and for a definitive and a confirmatory diagnosis.
STUDY OF CLINICAL PROFILE AND RISK FACTORS FOR ISCHEMIC STROKE IN YOUNG ADULTS
Authors:   Professor and Head of Department, Department of Medicine, N.S.C.B. Medical College, Jabalpur (M.P.)., Gupta Ritu , Kumar Warkade Vinay ,   Assistant Professor, Department of Medicine, N.S.C.B. Medical College, Jabalpur (M.P.)., A.K Chethan ,   Postgraduate Resident, Department of Medicine, N.S.C.B. Medical College, Jabalpur (M.P.).
Published: February 2023

Background: Stroke in young adults has become a rising concern in developing countries as it leads to large economic impact by causing disability in the most economically productive years. Although stroke is uncommon in young age group, we are facing patients with ischemic stroke in young adults in daily practice. Objective: To study the clinical profile and risk factors for ischemic stroke in young adults (15-49 years). Method: It is a prospective study in which patients with ischemic stroke fulfilling the inclusion criteria were evaluated for risk factors and clinical profile was assessed. Results: In this study 73 patients with ischemic stroke between 15-49 years were evaluated. Most of the patients were male (63%). The most common risk factors were dyslipidemia (67.1%), metabolic syndrome (64.3%), hyperhomocysteinemia (58.9%), smoking (52%) and hypertension (44.2%). Patients were further divided into two age groups (16-32 years and 33-49 years) for comparison. Metabolic syndrome and hypertension were significantly more frequent in age group of 33-49 years with p value of <0.05 but we could not find difference between two age groups for rest of the risk factors. Conclusion: Most of these are traditional risk factors which were previously seen in older age group, but now we are encountering these risk factors in younger age group also. As most of them are modifiable risk factors health education regarding lifestyle modification, health programs for preventing and treating these risk factors should be started to reduce the mortality and morbidity of stroke among socioeconomically active age group.
HEPATOPROTECTIVE ACTIVITY OF HOMALOMENA AROMATICA AGAINST CCL4 INDUCED LIVER INJURY IN SWISS ALBINO MICE
Authors:   Department of Zoology, Gauhati University, Guwahati- 781014, Assam, India., Das Madhubanti , Konwar Juri ,   Department of Zoology, Gauhati University, Guwahati- 781014, Assam, India., Chandra Kalita Jogen ,   Department of Zoology, Gauhati University, Guwahati- 781014, Assam, India.
Published: February 2023

The in vivo hepatoprotective activity of Homalomena aromatica was evaluated in carbon tetrachloride-induced hepatic injury model in Swiss albino mice. Effects of the methanolic rhizome extracts of Homalomena aromatica (HAME) at a dose of 200 mg/kg body weight and 500 mg/kg body weight was tested for its efficacy on CCl4 (1ml/kg body weight) induced liver injury. Hepatic toxicity enzyme markers and histological parameters were studied. Daily oral administration of HAME (500 mg/kg) reduced liver toxicity marker enzyme activity significantly as compared to the control. The results were also supported by the histopathological studies. Recovery of the liver tissue was observed in the highest dose (500 mg/kg) of HAME. The progression of liver damage could be inhibited by the protective effect of HAME and the normal architecture of the liver could be preserved. The plant can therefore be a potential therapeutic candidate to treat liver injury.
MINOCA mimic: Type 2 myocardial infarction due to severe aortic stenosis complicated by cardiogenic shock
Authors: Islam Momin , Al Hennawi Hussam , Bakir Mohamad , Khedr Anwar , Goel Sachin S
Published: February 2023

Acute myocardial infarction without significant obstructive coronary disease presents a challenging clinical entity that requires timely intervention. The term myocardial infarction with nonobstructive coronary arteries (MINOCA) describes a working diagnosis attributed to varying etiologies in patients with a presumed ischemic cardiac condition. Several overlapping etiologies can be classified as type 2 myocardial infarction (MI). The 2019 AHA statement established diagnostic criteria and clarified the associated confusion, aiding in appropriate diagnosis. In this report, we present a case of demand-ischemia MINOCA and cardiogenic shock in a patient with severe aortic stenosis (AS).
Chagas disease-induced ventricular tachycardia: A case report
Authors: Alhassani Zaineb , Al Hennawi Hussam , Sevella Prerana , Mena Carolina Severiche , Coppola Kathleen
Published: February 2023

Chagas disease is a protozoal infection caused by Trypanosoma cruzi (T. cruzi) that can affect many organ systems. Chagas cardiomyopathy tends to affect 30% of infected individuals. Cardiac manifestations include myocardial fibrosis, conduction defects, cardiomyopathy, ventricular tachycardia, and sudden cardiac death. In this report, we discuss a 51-year-old male who presented with recurrent episodes of non-sustained ventricular tachycardia refractory to medical therapy.
Lessons from the first-in-human in vivo CRISPR/Cas9 editing of the TTR gene by NTLA-2001 trial in patients with transthyretin amyloidosis with cardiomyopathy
Authors: Kotit Susy
Published: February 2023

Study and results: The first-in-human in vivo CRISPR/Cas9 trial of TTR Gene editing by NTLA-2001 in patients with Transthyretin Amyloidosis and cardiomyopathy was designed to evaluate the safety, tolerability, efficacy, and pharmacokinetic and pharmacodynamic responses to IV NTLA-2001 administration and its effect on serum transthyretin (TTR) levels in patients with ATTR amyloidosis and cardiomyopathy.  Twelve subjects received NTLA-2001 (three NYHA I/II subjects at 0.7 mg/kg, three subjects at 1.0 mg/kg, and six NYHA III subjects at 0.7 mg/kg). Serum TTR levels were reduced from the baseline in all subjects (mean>90% after 28 days). Mean % reductions (+/-SEM) from baseline to day 28 were: NYHA I/II at 0.7 mg/kg = 92% (1%), at 1.0 mg/kg = 92% (2%), and for NYHA III at 0.7 mg/kg = 94% (1%) maintained through 4-6 months. Two of the 12 patients (16.7 %) reported a transient infusion reaction. One patient experienced a grade 3 infusion-related reaction that resolved without any clinical sequelae.
Fitting Structure-Data Files (.SDF) Libraries to Progenesis QI Identification Searches
Authors: Sanches Pedro , de Oliveira Danilo , dos Reis Ivan , Fernandes Anna , Silva Alex , Eberlin Marcos , Carvalho Patrícia , Duarte Gustavo , Porcari Andreia
Published: February 2023

Progenesis QI (PQI) is a multiplatform bioinformatics tool that facilitates the identification workflow for metabolomics experiments. PQI uses fragmentation data provided by MassBank of North America (MoNA) libraries, among others, for metabolite annotation. However, PQI does not officially support MoNA libraries and other libraries based on structure-data files (.sdf). This paper describes the development and application of a software named MoNA to Progenesis QI Library Converter, allowing PQI and MoNA by correcting the fragmentation data of the library for Progenesis readability. We evaluated several public experimental datasets, including human plasma, plant extracts, cultured cells, bacteria, rat serum, and rat hippocampus. The results showed that it is mandatory to proceed with file conversion of each library to allow PQI to access fragmentation information from .msp (main spectra profile) files. This step is highly recommended to improve the identification level of the metabolites.
Design of downhill regenerative braking control method for hybrid electric vehicle
Authors: Miao Jia
Published: February 2023

In order to improve the downhill regenerative braking control effect of hybrid electric vehicle (HEV), this paper designs a downhill regenerative braking control method for hybrid electric vehicle (HEV). Firstly, the structures of regenerative braking system, auxiliary braking system and eddy current retarder (ECR) are analyzed. Secondly, the braking torque of ECR when HEV downhill braking is calculated. Then, the braking process of HEV is dynamically analyzed, and the braking force distribution constraint of HEV is realized according to the relevant laws and regulations. Finally, the downhill regenerative braking control of HEV is realized based on the braking force distribution coefficient. The results show that when the vehicle speed is up to 120 km·h, the speed control can still be completed within 2 s by using the proposed method, indicating a good regenerative braking effect.