bluuebunny/crossref_metadata_2025 huggingface dataset:
Geç Osmanlı, Erken Cumhuriyet dönemi (1920-1940) Anadolucu coğrafya literatürü ve genel özellikleri
Authors: ÇETİN Bayram
Published: April 2020

Anadoluculuk, 20. yüzyılın başında Osmanlı Devleti’nin buhranlı dönemlerinde doğmuş, Cumhuriyet’le birlikte etkinliğini sürdürmüş bir fikir hareketidir. Edebiyat başta olmak üzere felsefe, sosyoloji, tarih ve coğrafya literatürünü etkilemiştir. Eldeki çalışma 1920 ila 1940 yılları arasında bu fikir hareketiyle ortaya çıkmış, Anadolucu coğrafya yazınının tespiti ve temel özelliklerini belirleme amacındadır. Çalışma, Türkiye’de kültürel, felsefi ve siyasi fikir hareketlerinin coğrafya literatürünün gelişimine olan etkisine örnek oluşturması bakımından önem arz eder. Bu doğrultuda, Anadoluculuk akımı çerçevesinde coğrafi bilginin yeri ve rolü nedir? Akım çerçevesinde üretilen coğrafya yazını, bilgi ve yaklaşım yönüyle Türkiye coğrafya literatürüne herhangi bir katkı vermiş midir? gibi sorulara cevap aranmıştır. Anadoluculuk hareketinin yayın organları vasıtasıyla ya da münferit olarak yayımlanan Anadolucu coğrafya yazın örnekleri temel aldıkları ortak kavramlar (coğrafi ve ideolojik), kavramların oluşturduğu örüntü, akademik anlamda coğrafi bilgi düzeyleri, mekân ölçekleri ekseninde içerik analizine tabi tutulmuştur. Anadoluculuk hareketinin mekân odaklı yaklaşımı, yani Anadolu’yu toplumsal değerlerin örgütleyicisi olarak kabul etmesi, Anadolucu coğrafya literatürünün doğmasında etkilidir. Anadolu coğrafyasının bilimsel bir temelde yazılmasıyla, atıl olan vatanın tanınması ve gelişimi için alt yapı oluşturma gayesi güdülmüştür. Anadolu’yu temel alan coğrafya literatürünün, Türkiye coğrafyasına (özellikle kitaplar) yönelik çalışmaların ilk örneklerini teşkil etmesi nedeniyle, Anadolu-Türkiye eksenli monografya çalışmalarının gelişimine katkı sağladığı düşüncesini taşımaktayız. Anadolucu coğrafya yazınının burada verilen örneklerle sınırlı olamayacağı, 19. ve 20. yüzyıl geç Osmanlı ile erken Cumhuriyet dönemi coğrafya literatürünün tanınmasına bağlı olarak zamanla genişleyeceği kanaatindeyiz.
Okul Öncesi Öğretmenlerinin Sınıfta İstenmeyen Davranışlara Karşı Sınıf Yönetim Stratejilerine Yönelik Görüşleri
Authors: KUTLU ABU Neşe , ARSLAN Büşra
Published: April 2020

Bu
araştırmanın amacı, okul öncesi öğretmenlerinin sınıf yönetim uygulamaları ve
stratejilerine, istenmeyen davranışların giderilmesinde eğitim programının
işlevselliğine ilişkin görüşlerini incelemektir. Araştırmada, nitel araştırma
yöntemlerinden olgubilim deseni kullanılmıştır. Araştırmanın çalışma grubunu
2018-2019 eğitim öğretim yılında Amasya’da okul öncesi eğitim kurumlarında
görev yapan sekiz öğretmen oluşturmaktadır. Araştırmada yarı yapılandırılmış
görüşme formu kullanılmış olup, verilerin analizinden tümevarımsal analizden
yararlanılmıştır. Araştırmadan elde edilen bulgulara göre öğretmenler
çocuklarda itme, vurma gibi zorbalık davranışların sıklıkla görüldüğünü ifade
etmiş ve bu davranışların giderilmesinde uyarı gibi geleneksel yolların tercih
edildiğini, az sayıda öğretmen çocukları farklı alanlara çekerek çeşitli
önlemleri alındıklarını ifade etmiştir. Öğretmenler istenmeyen davranışların
giderilmesinde spor ve müzik aktivitelerinin artırılması, kazanımların
farklılaştırılması, görev anlamında eklentilerin yapılması gerektiğini ve bu
konuda çeşitli eğitimlerin verilmesi gerektiğini düşünmektedir. İleriki
çalışmalarda istenmeyen davranışların önlenmesi ve etkili sınıf yönetimi
konularında hem teorik hem de uygulamaya dönük olarak öğretmen eğitimlerinin
gerçekleştirilmesi önerilebilir.
ESTUDO BIBLIOMÉTRICO DAS PRODUÇÕES CIENTÍCAS SOBRE ECONOMIA ECOLÓGICA, MULTIFUNCIONALIDADE DA AGRICULTURA E PESCA ARTESANAL
Authors: Cajado Diana Mendes , Meireles Antonio Jeovah de Andrade , Casimiro Filho Francisco
Published: April 2020

O método bibliométrico corrobora para identifica ção das produções vinculadas aos periódicos de relevância da área de interesse. Além de conter um resultado quantitativo, apresenta o panorama da pro dução de forma esp e cializada e temporal, ainda oportuniza ao pesquisador selec ionar sua amostra para estudos do tipo review e orienta a construção das bases teórico conceit uais em diversas áreas do conhecimento. O artigo traz como objetivo principal realizar o levantamento da produção científica sobre as categorias: pesca artesanal; multifuncionalidade da agricultura familiar e economia ecológica, além da identificação de possíveis correlações entre as categorias e caracterização do panorama da produção ex istente. Os gráficos de quantidade de publicações por ano, áreas de concentração da produção científica, foram os outputs considerados nesta pesquisa. Além disso, foram consideradas as variáveis por categoria: quantidade de artigos publicados, ano da primeira publicação, artigo mais citado e seu referente ano, pais de maior de produção, título da obra mais citada e número de citações. A plataforma utilizada para o levantamento dos resultados bibliométricos foi a Scopus em decorrência de sua característica interdisciplinar e difusão nos estudos desta natureza. As categorias foram inseridas e pesquisadas isoladamente e escrita em língua inglesa. O estudo mapeou a evolução das produções cientificas sobre das categorias economia ecológica, multifuncionalidade da agricultura familiar e pesca artesanal. Observou-se, de modo geral, que há maior incidência de produção científica a partir dos anos 2000, apesar da ocorrência de alguma oscilação. As três categorias apresentam em comum produção científica nas áreas de Meio ambiente e Ciências sociais.
Analysis on the model of the combination of medical and health care from the perspective of aging
Authors: Chunyan Yang , Hanwen Zhang , Mei Yin
Published: April 2020

China has entered the aging society, how to achieve healthy and active aging is Chinas current urgent social problems to solve. Combined with Chinas national conditions, the combination of medical and health care pension mode emerged. But in practice, there are also a variety of problems. This paper reviews the combination of medical and health care, in order to provide a new solution to the existing problems.
Physical activity as a factor influencing on cognitive disorders
Authors: Chupryaev Ilia K. , Ponomareva Svetlana D. , Yasakova Alexandra V. , Frolova Elena V.
Published: April 2020

The article presents the results of modern research regarding the mechanisms of the positive effect of physical activity on cognitive functions, the benefits of aerobic exercise, and recommendations on physical activity for older adults with cognitive impairment.
In-Vision Continuity Announcers
Authors: De Leeuw Sonja , Mustata Dana
Published: April 2020

In-vision continuity announcers have played central – yet understudied –
roles in early television history. Through their performances on and off the
screen, they mediated the identity of the televisual medium in the 1950s and
1960s, popularizing it as a medium of sound and vision, a domestic and
gendered medium as well as a national and transnational institution.
Focusing primarily on Dutch and Romanian female in-vision continuity
announcers in the 1950s and 60s and making extensive comparisons with other
countries in Europe, this article illustrates how these early professionals
of television performed as part of a European-wide phenomenon of defining
the identity of the new televisual medium.
Hid(ing) Media Professionals
Authors: Ashton Daniel , Jeune Nic
Published: April 2020

This article addresses the hidden professions of television production
through examining the role of the First Assistant Director (1st AD). Drawing
on ‘industry talk’, this article examines the ways in which the role of the
1st AD is understood as central to the film and television production
process but regarded as overlooked or lacking in status and visibility.
Examining how 1st ADs position themselves and are positioned as both
invisible and visible is an opportunity to examine how the 1st AD understand
and challenge their status as hidden professionals.
AN INVESTIGATIVE METHODOLOGY THROUGH SOLID MODELLING AND NUMERICAL ANALYSIS FOR DESIGNING A THERMO-ELECTRIC GENERATOR SYSTEM
Authors: CHATURVEDI Ekansh , MAMTANI Vijay
Published: April 2020

This product development research project proposes a simplified novel methodology to design a thermo-electric generation (TEG) system. The iterative designs of complete assembly were prepared with the aid of Solidworks and the subsequent FEM analysis was aided by ANSYS fluent and transient thermal workbenches. The combustion chamber was subjected to a computational fluid dynamic study to generate flame profiles and to establish the temperature gradient distribution along the vertical length of inner surface of cylindrical chamber. The results of CFD analysis were then transported to the transient thermal workbench to calculate the charging time of whole system, which indeed founds the issues related to starting fuel efficiency of the system. A section model of the assembly was used to conduct the transient heat transfer analysis. The final results showed that after formation of a steady temperature gradient at the inner surface, the time required to completely charge up the system to achieve steady state came to be 30 minutes, which was found to be in good agreement with the operational constraints. Also, the temperature differences obtained between the hot and cold sides of TEG MARS modules were well within the safe limits. NOx emissions were also plotted and analysed.
Vitrectomy for the removal of intraocular foreign bodies: visual outcomes and prognostic factors
Authors: Aggarwal Somesh , C. Patel Kiran , D. Suthar Parth , H Shah Abhishek , Patel Mehul
Published: April 2020

Penetrating ocular injuries with intraocular foreign bodies may result in severe visual loss. The posterior segment IOFBs are best treated by pars plana vitrectomy.

To correlate the shape, size and location of posterior segment intraocular foreign bodies with visual outcome and its prognostic factors.

Tertiary care center of ophthalmology, Ahmedabad , India 

This is a prospective study of 40 eyes of 40 patients who underwent Pars Plana Vitrectomy for the removal of posterior segment intraocular foreign bodies in Regional Institute of India. We studied the following parameters: age, gender, wound site, IOFB characteristics (shape, size, location), initial and final visual acuity.

Among the study participants, 19 worked in factories, 6 were housekeepers, 7 were farmers and the remaining 5 patients were either unemployed or retired at the time of the injury. The foreign body was embedded in the surface of the retina (32.5%), located in the vitreous (55%) and in the sclera (12.5%). Nine patients (22.5%) developed delayed Retinal Detachment, which was the largest single cause of blindness in this group.

Our study concludes that the larger the size of posterior segment IOFB, presence of pre-existing or secondary RD, vitreous hemorrhage poorer the prognosis. We also emphasize the use of protective eye equipments at workplace in preventing this disability caused by penetrating ocular injury.
A teoria da forma de Kandinsky: uma compreensão artística e subjetiva de elementos geométricos
Authors: Moraes João Carlos Pereira de
Published: April 2020

O presente estudo emerge do encontro do seu pesquisador, um professor de matemática, com a obra Ponto e Linha sobre o Plano de Wassili Kandinsky (1866-1944).  Deste encontro emerge o objetivo de analisar a relação de Kandinsky, em sua Teoria da Forma, com o pensamento geométrico para a construção da arte abstracionista. Para tanto, o pesquisador realiza uma leitura crítica da obra do artista, apontando os olhares e significâncias subjetivas dadas para os elementos geométricos ponto, linha e plano. Como resultado, nota-se que a obra do artista em questão ressoa, a partir de tais elementos, muito dos aspectos históricos e culturais do início do século XX, tanto os presentes na ciência quanto no ideário da sociedade.
Sobre infância, saúde e gênero: discursos biomédicos na mídia impressa de 1990
Authors: Dalla Nora Heloísa Derkoski , Cadoná Eliane
Published: April 2020

Apresentamos, aqui, a análise das sessões saúde do Jornal Zero Hora do ano de 1990 - ano de publicação das leis n° 8.080/90 e n° 13.257/90 -, buscando evidenciar sentidos de Gênero, Saúde e Infância ali veiculados. Utilizamos como instrumentos teórico-metodológicos o Construcionismo Social e as Teorias de Gênero Pós-Estruturalistas, com foco na Análise de Discurso. A partir de eixos temáticos, refletimos sobre as (des)articulações discursivas veiculadas no jornal com os princípios do ECA e do SUS, no intuito de compreender os sentidos dados às temáticas evidenciadas naquele cenário.
Desafíos para una ciudadanía inclusiva: competencia digital entre adultos mayores y jóvenes
Authors: Amaro Agudo Ana , González García Erika , Martínez-Heredia Nazaret
Published: April 2020

En esta investigación se estudiarán las competencias digitales tanto en mayores como en jóvenes universitarios. El objetivo se basa en comparar descriptivamente la competencia digital en conocimiento y uso de las TIC en la comunicación social y aprendizaje colaborativo, competencias de uso para la búsqueda y tratamiento de la información, así como las competencias interpersonales de su uso entre jóvenes y mayores de la Facultad de Ciencias de la Educación de la Universidad de Granada (España). Se ha utilizado una metodología descriptiva de corte cuantitativo utilizando el cuestionario. Los resultados arrojan una enorme diferencia en torno a las competencias estudiadas entre ambas generaciones.
Editorial
Authors: Casadei Eliza Bachega , Nunes Mônica Rebecca Ferrari
Published: April 2020

Editorial
Anterior Single Odontoid Screw Fixation for Type II Odontoid Fractures: In A Cohort Study of 11 Patients and literature review.
Authors: BOZKURT Hüseyin , ARAÇ Densel
Published: April 2020

Objective: We aim to demonstrate the fusion efficiency of anterior screw fixation technique in all types of type 2 odontoid fracture by presenting a study of 11 cases and updating the literature.Methods: Retrospectively we analyzed 11 (8 males and 3 females) patients with type 2 odontoid fracture treated through anterior odontoid screw fixation in the Neurosurgery Department of XXX University Hospital between 2015 and 2018. All patient records were evaluated with current clinical, neurophysiological examination, radiological studies, and results. In operation we used retropharyngeal approach of Robinson and Smith and created a gutter in the superior edge of C3 corpus for proper trajection of screw. The patients were followed over a minimum period of eighteen months with a range (18-24 months). Assessments of the union, nonunion, screw displacement and overall, with complications were all recorded.Results: 10 patients had no postoperative complication. Separation of odontoid fracture was observed in 1 patient after discharge from hospital, but during follow up period computerized tomography revealed fusion of the odontoid of the patient. Our patients had no any complication such as screw related problems, pseudo-arthrosis and dysphagia.Conclusion: We recommend surgical treatment in all cases of type 2 odontoid fractures, including the anterior oblique fracture. The method used in our study is more reliable for trajection of screw and suitable for type 2 odontoid fracture, also fusion rate is higher than the other techniques
Psychosocial Problems and Unfulfilled Care Needs of Hospitalized Children as Perceived by Their Parents
Authors: ORAK Oya Sevcan , TUNÇ Ercan , İREN İnci , AKSÖZ Merve
Published: April 2020

Objective: The objective of this study was to determine psychosocial problems and care needs of hospitalized children as perceived by their parents. Methods: This descriptive study was performed with parents of 124 children receiving treatment in pediatric clinics of a university hospital. Data were gathered with Descriptive Characteristics Form for Parents and Children and Research Information Form. Results: Of all the parents included in the study, 65,3% reported being anxious, 62,1% reported being unhappy, 46% reported their children were anxious, 42,7% reported their children experienced problems with their eating habits and 41,9% reported their children continuously cried. 56,5% of the parents revealed the nurses were not available, 58,9% revealed their informed consent was not obtained before the procedures, 66,9% revealed they were not listened effectively, 72,6% revealed their children’s consent was not obtained before the procedures, 77,4% revealed their children were not allowed to express their opinions and 82,3% revealed their children were not listened effectively.Conclusion: The parents were found to have such psychosocial problems as anxiety, unhappiness, continuously wanting to cry, fear and despair and their children were found to have such psychosocial problems as anxiety, problems with eating habits, continuously crying and fear. In addition, both parents and children had insufficiently fulfilled psychosocial needs concerning informed consent, effective listening and expressing their opinions.
Evaluation of Effect of Disinfection Systems on Bond Strength of Root Canal Sealers
Authors: ÇAKICI Fatih , ÇAKICI Elif Bahar , ILKER Alper , TOPÇUOĞLU Hüseyin
Published: April 2020

Objective: The aim of this in vitro study is to evaluate and compare the effects of different disinfection methods (NaOCl irrigation, CHX irrigation, laser, PDT) on the bond strength of different root canal sealers (AH Plus sealer, MTA Fillapex, EndoSequence BC Sealer ).Methods: In this study, one hundred and twenty extracted human mandibular premolar teeth were used. The teeth were randomly divided into 3 experimental groups and 12 subgroups using the website (3 different sealers and 4 different disinfection methods). Two slices were obtained from apical part, middle part and coronal part of each root. The push-out test was performed on each slice with a universal test machine. The maximum load applied to the ﬁlling material before failure was recorded in Newtons (N) and converted to megapascals (MPa). Data were subject to Kruskal- Wallis test. Mann- Whitney U test was used for pairwise comparison with bonferroni correction. Significance level was set at a = 0.05Results: Kruskal Wallis test indicated that there were significant differences among the sealer groups for apical (p =0 ,000) and middle sections (P = 0,001), and coronal sections (P = 0,000). Conclusion: Under the study limitation; the bonding strength of root canal sealers is influenced by disinfection methods.
Permian - Triassic – Jurassic lithostratigraphic units in the Campine basin and the Roer Valley Graben (NE Belgium)
Authors: DUSAR Michiel , LANGENAEKER Vital , WOUTERS Laurent
Published: April 2020

Permian to Lower Jurassic strata, deposited between Variscan and Cimmerian deformation phases, subcrop in the northeastern Campine basin and Roer Valley Graben (NE Belgium). Total preserved thickness attains 550 m (of which 520 m drilled) in the Campine basin and ca. 1500 m (of which 1250 m drilled) in the Roer Valley Graben. Discovery of these concealed deposits is due to coal exploration of the Campine basin; further interest is linked to their potential for energy production or storage. Permo-Triassic sediments displaying Germanic facies were deposited on the southern margin of the Southern Permian Basin; Pangaea break-up associated with opening of the North Atlantic created conditions for deposition of the fully marine Jurassic sediments. Therefore, the stratigraphical succession in northeastern Belgium is closely related to the Dutch stratigraphical nomenclature.
Avaliação integrada do desempenho visual e eficiência energética pelo DIALux evo 8 para projetos de iluminação artificial
Authors: Moraes Júlia Silva de , Muros Alcojor Adrián , Bittencourt Leonardo Salazar
Published: April 2020

O comportamento ambiental dos edifícios vem sendo discutido visando integrar aspectos quantitativos e qualitativos do desempenho energético ao processo de elaboração de projetos de iluminação artificial. O objetivo deste artigo é examinar a capacidade do software DIALux evo 8 em avaliar, de forma integrada, o desempenho visual e a eficiência energética de modelos virtuais durante a elaboração de projetos de iluminação artificial residencial. O delineamento do estudo consistiu na: (i) definição de indicadores de desempenho visual e eficiência da iluminação artificial; (ii) verificação do potencial de elaboração destes indicadores pelo software; (iii) aplicação da simulação em ambiente residencial. Os indicadores relativos ao conforto visual avaliados foram: iluminância mantida, uniformidade, índice limite de ofuscamento unificado, índice reprodução de cor e temperatura de cor. Os indicadores concernentes à eficiência energética avaliados foram: eficiência luminosa, densidade de potência da iluminação, densidade de potência limite da iluminação e densidade de potência relativa. A simulação objetivou fomentar a discussão da capacidade de análise por meio das métricas determinadas pelo software e dos aspectos relacionados à interface com o usuário durante as análises de desempenho visual e energético. Verificou-se que todos dos indicadores propostos são calculados pelo DIALux evo 8, porém a análise integrada propiciada pela interface gráfica do software prioriza as análises das iluminâncias. O índice limite de ofuscamento e as densidades de potência da iluminação são apresentados somente na documentação, demandando análises comparativas realizadas externamente ao programa. Observou-se limitações referente às normas utilizadas pelo software, exclusiva à EN 12464-1, consequentemente não incluindo tipologias residenciais. A contribuição deste trabalho consiste em discutir os recursos oferecidos pelo software e suas repercussões na gestão de projetos luminotécnicos.
The Risk of Myocardial Infarction in Patients with Atrial Fibrillation Taking a Direct Thrombin Inhibitor: Myths and Reality
Authors: Tatarsky B. A. , Kazennova N. V. , Napalkov D. A.
Published: April 2020

The purpose of this review is to analyze the results of randomized clinical trials, meta-analyses of cohort and observational studies in real clinical practice on the influence of dabigatran etexilate on the risk of myocardial infarction in patients with atrial fibrillation. A pivotal RE-LY study on dabigatran use in patients with atrial fibrillation did not show statistically significant differences in the frequency of myocardial infarction between any of the doses of dabigatran and warfarin, and the risk of coronary events did not depend on the presence of coronary heart disease or myocardial infarction in the patient's history. Subsequently, a number of meta-analyses have reported an increased risk of myocardial infarction when dabigatran was administered to patients with atrial fibrillation. In general, these studies were characterized by conflicting data, which did not allow to draw any definite conclusions regarding the use of dabigatran in relation to the risk of myocardial infarction. Two FDA cohort observational studies were published in 2014 and 2017, and the former was significantly criticized by experts, and the results of the second study did not provide a definitive answer to the question about the importance of the effect of dabigatran on the development of myocardial infarction in patients with atrial fibrillation. Even more "confusing" the problem arose after the publication of meta-analyses of randomized trials, which showed that the risk of myocardial infarction was increased in patients treated with direct oral anticoagulants compared to patients treated with warfarin. This review provides high quality evidence for the efficacy of dabigatran in preventing myocardial infarction and other vascular complications in patients with atrial fibrillation.
Quantitative Analysis of the Effect of Perforation Interaction on Perforation Stability Using the Finite Element Method
Authors: Araki Naoto , Morita Nobuo
Published: April 2020

Oil and gas reservoirs are normally completed as either openhole or perforated wells. Although a perforated well has hundreds of perforations, a single perforation is normally used for perforation interaction analysis, assuming the perforations are shot symmetrically and the stress state around a perforation is symmetric in both vertical and horizontal directions. However, for the single/double spiral perforations shot in inclined wells, no vertical and horizontal symmetry surfaces exist. The required elements for a multiperforation model are more than 10,000, which results in complex mesh generation and long computation time. In this study, we investigate perforation interaction to find the optimal perforation design that yields the highest productivity while maintaining mechanical stability. The practical implications of this work to the field are (1) the drawdown to cause perforation instability for gas flow is significantly less than oil flow. Therefore, when the gas flow becomes dominant either by enhanced oil recovery with CO2 or by low bottomhole flowing pressure below bubblepoint, the drawdown should be reduced to avoid sand production. (2) For inclined wells, the X-shaped staggered orientation perforations are the best pattern to delay onset of sand production without significantly reducing the well productivity. (3) For near-vertical wells, the conventional nonstaggered perforation pattern delays the onset of sand production due to the stress reduction in the vertical direction compared with the commonly used staggered perforation patterns.
Extensional Effects during Viscoelastic Polymer Flooding: Understanding Unresolved Challenges
Authors: Azad Madhar S. , Trivedi Japan J.
Published: April 2020

Several studies have tried to relate polymers’ enhanced oil recovery (EOR) potential to their viscoelastic characteristics such as onset, rheo thickening, extensional viscosity, and Deborah number (De). Contradictions prevail when it comes to reduction in residual oil saturation (Sor) during polymer flooding and the role of extensional properties. De calculated using the oscillatory relaxation time fails to explain the different pressure profiles exhibited by the viscous and viscoelastic polymers. Extensional viscosity has been ignored in many studies as the reason for additional Sor reduction based on the core-scale apparent viscosity and core-scale capillary number (Nc). In recent studies, a significant oil mobilization was shown by the viscoelastic polymers even before the critical Nc, which indicates that the capillary theory breaks out under specific conditions during polymer flooding. Moreover, the additional residual oil recovery caused by the high-salinity polymer solutions cannot be explained by the oscillatory De.

In this paper, we compile and examine many such unresolved challenges from various literature with rheological and petrophysical insights. The uniaxial bulk extensional rheology is performed on the relevant polymers using a capillary breakup extensional rheometer to measure the extensional relaxation time, maximum extensional viscosity at the critical De, and strain hardening index. A detailed analysis signifies the role of extensional rheology on the viscoelastic onset, rheo thickening, and Sor reduction even under varying salinity conditions. The results also highlight the advantages of extensional rheology over oscillatory rheology and validate the capillary theory using modified capillary number.
Impact of the comprehensive geriatric assessment on treatment decision in geriatric oncology.
Authors: Sourdet Sandrine , Brechemier Delphine , Steinmeyer Zara , Gerard Stephane , Balardy Laurent
Published: April 2020

Background: The comprehensive geriatric assessment (CGA) is the gold standard in geriatric oncology to identify patients at high risk of adverse outcomes and optimize cancer and overall management. Many studies have demonstrated that CGA could modify oncologic treatment decision. However, there is little knowledge on which domains of the CGA are associated with this change. Moreover, the impact of frailty and physical performance on change in cancer treatment plan has been rarely assessed.Methods: This is a cross-sectional study of older patients with solid or hematologic cancer referred by oncologists for a geriatric evaluation before cancer treatment. A comprehensive geriatric assessment was performed by a multidisciplinary team to provide guidance for treatment decision. We performed a multivariate analysis to identify CGA domains associated with change in cancer treatment plan. Results: 418 patients, mean age 82.8 ± 5.5, were included between October 2011 and January 2016, and 384 of them were referred with an initial cancer treatment plan. This initial cancer treatment plan was changed in 64 patients (16.7 %). In multivariate analysis, CGA domains associated with change in cancer treatment plan were cognitive impairment according to the MMSE score (p=0.020), malnutrition according to the MNA score (p=0.023), and low physical performance according to the Short Physical Performance Battery (p=0.010). Conclusion: Cognition, malnutrition and low physical performance are significantly associated with change in cancer treatment plan in older adults with cancer. More studies are needed to evaluate their association with survival, treatment toxicity and quality of life. The role of physical performance should be specifically explored.
Stem vacuole-targetted sucrose isomerase enhances sugar accumulation in sorghum
Authors: Liu Guoquan , Zhang Yan , Pan Yunrong , Davis Christopher Eric , Jing Hai-Chun , Wu Luguang , Godwin Ian D.
Published: April 2020

Background: Sugar accumulation is critically important in determining sugar crop productivity. Sorghum, especially high biomass sweet sorghum has shown great potential for biofuel. However, improvement in sugar content has been stagnant among sugar crops for decades. In this study, sorghum was investigated as a C4 diploid model for more complicated genomes such as maize and sugarcane. To promote sugar accumulation in sorghum, the sucrose isomerase (SI) gene, driven by stem-specific promoters A1 (A) or LSG2 (L) with a signal peptide, was designed to target the stem vacuole in grain sorghum inbred line (Tx430).Results: The study demonstrated that transgenic lines of grain sorghum can accumulate isomaltulose which accounted for 50-60% of total sugar (up to 1012 mM) in stalks. While the average sugar content is 118 mM in the control Tx430. Subsequently, the best-engineered line (L9) was crossed with an elite sweet sorghum variety (Rio). The total sugar contents were significantly higher in both F1 (up to 763 mM) and F2 (up to 821 mM) progenies than the sweet sorghum Rio (485 mM), representing 57% and 69% increase respectively. Those total sugar contents in those engineered sorghum lines are higher than in the field-grown sugarcane (600-700 mM). Physiological characterization demonstrated that the superior progenies of F2 hybrids had notably higher rates of photosynthesis, sucrose transport, and sink strength than controls.Conclusion: The genetic engineering approach has significantly enhanced total sugar content in grain sorghum and hybrids of (sweet X grain) sorghum. This research has put sorghum in the spotlight and frontier as a biofuel crop. More importantly, our results prove that the phenotype of high sugar content is heritable in the grain sorghum as well as hybrids. The massive increase in sugar accumulation would lead to enormous financial benefits for industrial and biofuel use. This study would have a substantial impact on renewable energy due to the supreme capacity of total sugar accumulation in transgenic sorghum.
Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patient
Authors: Lee Yu Ho , Kim Jin Sug , Jung Su Woong , Hwang Hyeon Seok , Moon Ju-Young , Jeong Kyung-Hwan , Lee Sang-Ho , Lee So-Young , Ko Gang Jee , Lee Dong-Young , Lee Hong joo , Kim Yang Gyun
Published: April 2020

Background Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commonly used methods of assessing physical performance.Methods We obtained data regarding gait speed and handgrip strength from 277 hemodialysis patients and evaluated their relationships with baseline parameters, mental health, plasma inflammatory markers, and major adverse clinical outcomes. Low physical performance was defined by the recommendations suggested by the Asian Working Group on Sarcopenia.Results The prevalence of low gait speed and handgrip strength was 28.2% and 44.8%, respectively. Old age, low serum albumin levels, high comorbidity index score, and impaired cognitive functions were associated with low physical performance. Patients with isolated low gait speed exhibited a general trend for worse quality of life than those with isolated low handgrip strength. Gait speed and handgrip strength showed very weak correlations with different determining factors (older age, the presence of diabetes, and lower serum albumin level for low gait speed, and lower body mass index and the presence of previous cardiovascular events for low handgrip strength). Patients with low gait speed and handgrip strength had elevated levels of plasma endocan and matrix metalloproteinase-7 and the highest risks for all-cause mortality and cardiovascular events among the groups (adjusted hazard ratio of 2.72, p = 0.024). Elderly patients with low gait speed and handgrip strength were at the highest risk for poor clinical outcomes.Conclusion Gait speed and handgrip strength reflected distinctive aspects of patient characteristics and the use of both factors improved the prediction of adverse clinical outcomes in hemodialysis patients. Gait speed seems to be a better indicator of poor patient outcomes than is handgrip strength.
Youth unemployment and mental health: Prevalence and associated factors of depression among unemployed young adults in Gedeo zone, Southern Ethiopia
Authors: Mokona Hirbaye , Yohannes Kalkidan , Ayano Getinet
Published: April 2020

Background: The high rate of unemployment among young adults in Ethiopia (aged 18 to 30 years) is a public health concern. The risk of mental health problems like depression is higher among the unemployed than among the employed. However, there is no study conducted on the prevalence and associated factors of depression among unemployed young adults in Ethiopia. Hence, this study is aimed to assess the prevalence and associated factors of depression among unemployed young adults in Gedeo zone, Southern Ethiopia.Methods: Community based cross sectional study design was employed among 1452 unemployed young adults in Gedeo zone, Southern Ethiopia from May to July, 2019. Systematic random sampling technique was used to select study participants. The presence of depression was assessed by using Patient Health Questionnaire-9 (PHQ-9) and data on socio-demographic characteristics of study participants was collected by using structured questionnaire. Data was coded and entered into Epi-Data version 3.1 and analyzed by SPSS version 20. A multivariable logistic regression analysis was carried out to identify factors associated with depression, and variables with p-values < 0.05 were considered as statistically significant. The strength of the association was presented by adjusted odds ratio with their 95% confidence interval. Result: The overall prevalence of depression among unemployed young adults in the present study was 30.9% (95% CI: 28.4%, 33.1%). Of the total study participants with depression, 56.7% had mild depression, 36% had moderate depression, and 7.3% had severe depression. Being male (AOR=1.40, 95%CI: 1.10, 1.80), long duration of unemployment (≥1years) (AOR=1.56, 95%CI: 1.21, 1.99), low self-esteem (AOR=1.32, 95%CI: 1.03, 1.68), poor social support (AOR=1.98, 95%CI: 1.34, 2.93), and current alcohol use (AOR=1.86, 95%CI: 1.33, 2.59) were significantly associated with depression. Conclusion: The results of our study indicated that depression is an important public health problem among unemployed young adults in Ethiopia. The results of our study suggest that policy makers and program planners should establish appropriate strategy for prevention, early detection and management of depression among this population. Moreover, this study also indicates that addressing the need of unemployed young people, improving access to care for depression is an important next step. Furthermore, we recommend further studies to understand the nature of depression among unemployed young people and to strengthen the current results.
Analysis of CCT7 Expression and Its Clinical Significance in Endometrial Cancer
Authors: Wang Liwen , Zhou Wei , Li Hui , Yang Hui , Shan Nianchun
Published: April 2020

Background: Endometrial cancer (EC) is a common gynecologic malignancy; myometrial invasion (MI) is a typical approach of EC spreads and an important index to assess tumor metastasis and outcome of EC patients. CCT7 is a member of the TCP1 chaperone family, involved in cytoskeletal protein folding and unfolding. In this study, the role of CCT7 in EC development was investigated. Methods: Clinical data for 87 EC cases and expression of CCT7 were analyzed. CCT7 was knocked out using siRNA-CCT7 in Ishikawa and RL95-2 cells, and their function about proliferation, apoptosis and invasion were further tested. Bioinformatics methods were used to predict the potential pathways of CCT7 in EC development.Results: The rates of CCT7-positive cells in EC and adjacent normal endometrium tissues had significant difference (67.8% vs. 51.4%, p = 0.035), and the expression rate increased from low to high pathological stage (39.7% in the I/II stage, 71.4% in the III/IV stage, p = 0.029). Similar change was found in protein level. CCT7 expression differed significantly between the deep MI group (>1/2) and the superficial MI group (≤1/2) (P = 0.039). However, there were no differences with respect to age, pathological type and histological grade. CCT7 suppression induced a function-loss in in both Ishikawa and RL95-2 cells. Bioinformatics analysis demonstrated that EC patients with lower level CCT7 expression had better Overall survival (p= 0.0081). GO enrichment indicated that “RNA binding”, “Mitochondrion”, “Translation”, and “Spliceosome” were most significantly enriched potential pathways. Five hub genes, PSMA5, PSMD14, SNRPB, SNRPG and TXNL4A, were all significantly upregulated in EC and had positive correlation with CCT7.Conclusions: CCT7 may be involved in EC development by excessively activating tumor cell function to promote MI or distant/nodal metastasis, which definitely impaired the prognosis of EC patients.
Immune Landscape in Burkitt Lymphoma reveals M2-macrophage polarization and Correlation between PD-L1 expression and Non-Canonical EBV latency program
Authors: Granai Massimo , Mundo Lucia , Akarca Ayse U , Siciliano Maria Chiara , Rizvi Hasan , Mancini Virginia , Onyango Noel , Othieno-Abinya Nicholas , Maha Ibrahim , Margielewska Sandra , Wi Wenbin , Bibas Michele , Piccaluga Pier Paolo , Quintanilla-Martinez Leticia , Fend Falko , Lazzi Stefano , Leoncini Lorenzo , Marafioti Teresa
Published: April 2020

BACKGROUND: The Tumor Microenviroment (TME) is a complex milieu that is increasingly recognized as a key factor in multiple stages of disease progression and responses to therapy as well as escape from immune surveillance. However, the precise contribution of specific immune effector and immune suppressor components of the TME in Burkitt lymphoma (BL) remains poorly understood.METHODS: In this paper, we applied the computational algorithm CIBERSORT to Gene Expression Profiling (GEP) datasets of 40 BL samples to draw a map of immune and stromal components of TME. Furthermore, by multiple immunohistochemistry (IHC) and multispectral immunofluorescence (IF), we investigated the TME of additional series of 40 BL cases to evaluate the role of the Programmed Death-1 and Programmed Death Ligand-1 (PD-1/PD-L1) immune checkpoint axis. RESULTS: Our results indicate that M2 polarized macrophages are the most prominent TME component in BL. In addition, we investigated the correlation between PD-L1 and latent membrane protein-2A (LMP2A) expression on tumour cells, highlighting a subgroup of BL cases characterized by a non-canonical latency program of EBV with an activated PD-L1 pathway. CONCLUSION: In conclusion, our study analysed the TME in BL and identified a tolerogenic immune signature highlighting new potential therapeutic targets.
Feasibility and predictors of change of Narrative Exposure Therapy for displaced populations: A repeated measures design
Authors: Ghafoerkhan R.S. , Heemstra H.E. van , Scholte W.F. , Kolk J.R.J. van der , Heide F.J. ter , Rie S. M. de la , Verhaak L.M. , Snippe E. , Boelen P.A.
Published: April 2020

Background: Displaced victims of interpersonal violence, such as refugees, asylum seekers, and victims of sexual exploitation, are growing in numbers, and are often suffering from a posttraumatic stress disorder (PTSD). At the same time these victims are known to benefit less from trauma-focused therapy (TFT), and to be less compliant to treatment. The objective of this paper is to describe the rationale and research protocol of an ongoing trial that aims to evaluate different variables that might influence the feasibility of TFT for the study population. Specifically, perceived daily stress, emotion regulation, and mood are investigated as predictors of change in PTSD symptoms during a trauma-focused therapy (Narrative Exposure Therapy (NET)). The feasibility of administering measures tapping these constructs repeatedly during treatment will also be evaluated. Methods/design: Using an observational treatment design, 80 displaced victims of interpersonal violence will be measured before, during, and after partaking in NET. Several questionnaires tapping PTSD plus the aforementioned possible predictors of PTSD change will be administered: Post-Traumatic Stress Disorder Checklist-5, Perceived Stress Scale, Difficulties in Emotion Regulation Scale-18 (pre-test, post-test, and follow-up),subscale impulsivity of the Difficulties in Emotion Regulation Scale-18, Perceived Stress Scale short version, Primary Care Posttraumatic Stress Disorder and a single Mood item (each session). Multilevel modelling will be used to examine the relation between the possible predictors and treatment outcome.Discussion: The present study is the first to examine the interplay of facilitating and interfering factors possibly impacting treatment feasibility and effectiveness in displaced victims of interpersonal violence with PTSD receiving NET, using repeated measures. The current study can help to improve future treatment based on individual characteristics. Trial registration: Netherlands Trial Register: NTR7353, retrospectively registered. Date of registration: July 11th 2018.
Human Amniotic Epithelial Cells Recover Mouse model of Parkinson’s Disease mainly by Neuroprotective，Anti-oxidative and Anti-inflammatory factors
Authors: Zhang Jiaofei , Li Hui , Yang Hao , Lin Jianhua , Wang You , Zhang Qianjun , Gao Wei-Qiang , Xu Huiming
Published: April 2020

The authors have withdrawn this preprint due to author disagreement.
Optimization of Machining Parameters of Aluminum Alloy BS-1474 2014 A using Response Surface Methodology
Authors: javaid waqas , Iqbal Tauqeer , Hassan Ammar ul
Published: April 2020

High surface quality, optimum Material Removal Rate (MRR) and Tool-Chip Interface temperature (T c ) have significant importance in machining process. Similarly, dimensional accuracy in machining process also relies heavily on machining parameters. In machining operations, there are a number of parameters which have direct or indirect effect on the Surface Roughness (Ra) and MRR of the product. The surface roughness and MRR in turning process are affected by spindle speed (SS), feed rate (FR) and depth of cut (DOC). The optimization of turning parameters will be very helpful in improving quality of manufacturing and machining cost. In order to have an improved product, extensive research has been carried out to optimize machining process. The current research is focused at Response Surface Methodology (RSM) of turning process of Aluminum alloy (BS-1474 2014 A) by using variable sets of machining parameters i.e., SS, FR and DOC with carbide tipped tool. Multiple experiments were performed on CNC Lathe machine by using different combinations of process parameters. Response surface methodology was applied to reach theoretical values of the responses parameters (i.e, Ra, MRR, T c ) and an agreement was observed between actual machining results and methodology values. Design Expert-7 was used as a statistical tool to come to a conclusion on whether achieved results are optimum for turning process or otherwise. For a close correlation, comparison between hypothetical and investigational data is also the part of this research. Significant agreement between theoretically optimized machining parameters and experimental data has been observed.
The use of negative-pressure wound therapy after total knee arthroplasty is effective for reducing complications and the need for reintervention.
Authors: Helito Camilo Partezani , Sobrado Marcel Faraco , Giglio Pedro Nogueira , Bonadio Marcelo Batista , Pecora Jose Ricardo , Demange Marco Kawamura , Gobbi Riccardo Gomes
Published: April 2020

Background: Compare the complications of patients undergoing total knee arthroplasty (TKA) who used a portable negative-pressure wound therapy (NPWT) device in the immediate postoperative period with those of a control group. Methods: A total of 296 patients were evaluated. Patients were divided into two groups: those who used NPWT for seven days in the postoperative period (Group 1) and those who used conventional dressings (Group 2). Demographic data, comorbidities, local parameters related to the surgical wound and complications were evaluated.Results: The groups did not differ in regard to sex, age and clinical comorbidities. Overall, 153 (51.7%) patients had at least one risk factor for wound complications. Patients who used NPWT had a lower rate of complications (28.5% vs. 45.7%, p = 0.001) and a lower rate of reintervention in the operating room (2% vs. 8.5%, p = 0.001). Patients in group 1 had a lower incidence of hyperaemia (14.7% vs. 40.2%, p = 0.01), skin necrosis (2.1% vs. 8.5%, p = 0.04) and wound dehiscence (3.1% vs 10.1%, p = 0.03). The use of NPWT was a protective factor for the presence of complications, with an odds ratio of 0.36 (95% CI 0.206-0.629).Conclusion: The number of complications related to the wound after TKA is high; however, most of them are minor and have no impact on the treatment and clinical evolution of patients. The use of NPWT decreased the number of surgical wound complications, especially hyperaemia, dehiscence and necrosis, and reduced the need for reintervention.