bluuebunny/crossref_metadata_2025 huggingface dataset:
Decreasing Social Isolation to Enhance Mental Health among Older Adults in China: A Mediation Analysis of Aging Attitude
Authors: Cheng Xinfeng , Cosco Theodore D. , Ariyo Tolulope
Published: September 2021

A large body of literature has examined the relationship between social isolation and mental health in older adults. However, only a few studies have examined the mediating effects of aging attitudes on this relationship. This study investigated the impact of objective isolation (family isolation, friend isolation, and community isolation), and subjective social isolation (perceived isolation) on the mental health of Chinese older adults, and the mediating effect of aging attitudes. Mental health was assessed through depressive symptoms, using the Epidemiological Studies Depression Scale. The research sample comprising 7,024 elderly adults (60 years old), was obtained from the nationally representative 2014 Chinese Longitudinal Aging Social Survey. The regression analysis indicated that objective social isolation and subjective social isolation are independently related to mental health among older adults. Furthermore, in the mediation analysis, aging attitude was found to play a significant mediating role between social isolation and mental health. Our study concludes that though, objective and subjective social isolation are issues affecting mental health in older people, however, aging attitude also needs to be factored in that relationship as we have shown that there is a significant mediating effect.
Football Match Dynamics Explored by Recurrence Analysis
Authors: Lames Martin , Hermann Sebastian , Prüßner René , Meth Hendrik
Published: September 2021

A widely accepted notion of football matches in performance analysis (PA) is to consider them as dynamic interaction processes with emerging behaviors. The description and analysis of these processes requires specific methods. Recurrence analysis is a technique for analyzing complex systems in many domains like astrophysics, earth sciences, engineering, biology, cardiology, and neuroscience. Its general concept is to examine the recurrence behavior of a system, as in when, how often and how close its trajectory in a phase space returns to a previous state. The aim of the study is to apply recurrence analysis to football matches. Positional data from 21 football matches of a German Bundesliga team were examined. The phase space was made up of the field players' x,y-positions at each second of the match. For each pair of seconds, the average distance of all the players between their positions at these two time points was calculated. Recurrence plots (RPs) were obtained by color-coding these distances. With a recurrence threshold of rt = 9 m and a minimum line length of lmin = 3 s, general recurrence parameters were calculated to characterize the individual recurrence behaviors of each match. Three football-specific recurrence parameters were defined to represent recurrence properties of open play. RPs showed commonalities (typical features indicating set plays and continuous gameplay) as well as unique structures during each match (number, distribution, and sequence of typical features). The recurrence parameters showed several significant correlations with traditional performance indicators like number of goals and passes completed, e.g., the correlation between number of goals and recurrence rate is r = −0.622 (p = 0.003). By extending the sample and design of recurrence studies, there is great potential for recurrence analysis to improve both the practical and theoretical potential of performance analysis.
Exploring Topics in Bibliometric Research Through Citation Networks and Semantic Analysis
Authors: Mejia Cristian , Wu Mengjia , Zhang Yi , Kajikawa Yuya
Published: September 2021

This article surveys topic distributions of the academic literature that employs the terms bibliometrics, scientometrics, and informetrics. This exploration allows informing on the adoption of those terms and publication patterns of the authors acknowledging their work to be part of bibliometric research. We retrieved 20,268 articles related to bibliometrics and applied methodologies that exploit various features of the dataset to surface different topic representations. Across them, we observe major trends including discussions on theory, regional publication patterns, databases, and tools. There is a great increase in the application of bibliometrics as science mapping and decision-making tools in management, public health, sustainability, and medical fields. It is also observed that the term bibliometrics has reached an overall generality, while the terms scientometrics and informetrics may be more accurate in representing the core of bibliometric research as understood by the information and library science field. This article contributes by providing multiple snapshots of a field that has grown too quickly beyond the confines of library science.
A Survey for Machine Learning-Based Control of Continuum Robots
Authors: Wang Xiaomei , Li Yingqi , Kwok Ka-Wai
Published: September 2021

Soft continuum robots have been accepted as a promising category of biomedical robots, accredited to the robots’ inherent compliance that makes them safely interact with their surroundings. In its application of minimally invasive surgery, such a continuum concept shares the same view of robotization for conventional endoscopy/laparoscopy. Different from rigid-link robots with accurate analytical kinematics/dynamics, soft robots encounter modeling uncertainties due to intrinsic and extrinsic factors, which would deteriorate the model-based control performances. However, the trade-off between flexibility and controllability of soft manipulators may not be readily optimized but would be demanded for specific kinds of modeling approaches. To this end, data-driven modeling strategies making use of machine learning algorithms would be an encouraging way out for the control of soft continuum robots. In this article, we attempt to overview the current state of kinematic/dynamic model-free control schemes for continuum manipulators, particularly by learning-based means, and discuss their similarities and differences. Perspectives and trends in the development of new control methods are also investigated through the review of existing limitations and challenges.
Self-Monitoring of Balance Performance can Reduce the Rate of Falls Among Older Adults
Authors: Forth Katharine E. , Layne Charles S. , Madansingh Stefan I.
Published: September 2021

Background: 29% of older adults fall annually, resulting in the leading cause of accidental death. Fall prevention programs typically include exercise training and self-monitoring of physical activity has a positive effect on the self-efficacy and self-regulation of exercise behaviors. We assessed if self-monitoring of fall risk, without an intervention, impacts fall rates.

Methods: Fifty-three older adults had open access to a balance measuring platform which allowed them to self-monitor their postural stability and fall risk using a simple 1-min standing balance test. 12-month retrospective fall history was collected and a monthly/bimonthly fall log captured prospective falls. Participants had access to self-monitoring for up to 2.2 years. Fall history and fall incidence rate ratios and their confidence intervals were compared between the periods of time with and without access to self-monitoring.

Results: A 54% reduction in the number of people who fell and a 74% reduction in the number of falls was observed when participants were able to self-monitor their postural stability and fall risk, after normalizing for participation length. Further, 42.9% of individuals identified as having high fall risk at baseline shifted to a lower risk category at a median 34 days and voluntarily measured themselves for a longer period of time.

Discussion: We attribute this reduction in falls to changes in health behaviors achieved through empowerment from improved self-efficacy and self-regulation. Providing older adults with the ability to self-monitor their postural stability and intuit their risk of falling appears to have modified their health behaviors to successfully reduce fall rates.
Women's Right to Land Between Collective and Individual Dimensions. Some Insights From Sub-Saharan Africa
Authors: Errico Stefania
Published: September 2021

Women represent a large part of the 2.5 billion people who depend on lands managed through customary, community-based tenure systems and are especially reliant on commons for their lives and livelihoods. They have very often limited and unsecured access to land and natural resources and tend to be excluded from decisions concerning them. Far from representing a homogenous group, they face varying challenges that are the result of multiple and intersecting forms of discrimination, whereby gender dynamics intersect with other characteristics, such as age, disability, ethnic origin, or socioeconomic status. Peasant and indigenous women, in many instances, face the compounded impact of the lack of recognition and violation of the collective rights of their communities, which is often the legacy of histories of colonization, conquest, dispossession and discrimination, and patriarchal norms, exacerbated by neoliberalism and the commodification of land and natural resources. The nexus between individual and collective rights is one of particular importance, but has received limited attention, including as regards the gendered effects of human rights violations of collective rights. In the present article, the nexus between collective and individual rights of peasant and indigenous women is illustrated by considering the experience surrounding the recognition and implementation of collective rights to land in Sub-Saharan Africa and the impact on women's right to land. The article argues that peasant and indigenous women's right to land is best protected through interventions aimed at guaranteeing both their collective and individual rights. There is a need to take into account and address simultaneously the barriers that indigenous and peasant women face with regard to their collective as well as their individual rights. These barriers include those ascribed to the discrimination and social, economic and political marginalization suffered by their peoples and communities, as well as those related to patriarchal power structures within and outside them. Addressing these barriers requires the respect, protection and fulfillment of both collective and individual human rights of women and a careful analysis of the interaction between these rights.
Steering the Nexus: iZindaba Zokudla and Governing for Sustainability
Authors: Malan Naudé
Published: September 2021

“iZindaba Zokudla” means we talk about the food that we eat. iZindaba Zokudla is a public innovation lab that uses stakeholder-engagement methods to create “opportunities for urban agriculture in a sustainable food system.” iZindaba Zokudla is presented as an extra-institutional means to govern the water, land, energy, and waste nexus. This reflective essay critically describes iZindaba Zokudla and applies this to the design of institutional steering mechanisms to govern the food, water, land, and energy nexus towards sustainability. Governance is an intersubjective and interactive process between the subjects of governance and governance itself. Sustainability, as an interactive process, implies the creation of autocatalytic and symbiotic communities in society that integrates diverse actors and stakeholders, inclusive of scientific and lay actors, and ecosystems. iZindaba Zokudla is a means to govern and create such communities, and this article describes and reflects on how iZindaba Zokudla has created and managed such symbiotic communities or autocatalytic networks in the food system. The article generalises how the activities conducted in iZindaba Zokudla can be used to govern the water, land, energy, and waste nexus for sustainability. The article shows how iZindaba Zokudla has realised a progressive governance through the facilitation of its Farmers' Lab and website; how it has created opportunities for participation; and how it enables critical reflection in society.
Exploring Trends and Differences in Health Behaviours of Health Sciences University Students from Germany and England: Findings from the “SuSy” Project
Authors: Kalbus Alexandra , Boenecke Juliane , Holt Maxine , Powell Susan , Reintjes Ralf
Published: September 2021

Objectives: This research aimed to explore the health behaviours of health sciences students over time and across different settings.

Methods: A health behaviour surveillance system has been implemented in Hamburg and Manchester among under- and postgraduate health sciences students. Trends among the Hamburg sample were described. In a cross-sectional assessment, health behaviours across both universities were examined using multivariate regression analysis.

Results: Between 2014 and 2018, increasing trends in physical activity and cannabis and alcohol consumption were observed in Hamburg (n = 1,366). While fruit and vegetable intake was constantly low, tobacco smoking decreased. No clear trend was observed for stress perception. The comparison (n = 474) revealed that Manchester students had higher odds of smoking, excessive alcohol consumption, and fruit and vegetable consumption; and lower odds of being physically active, and consuming cannabis. No difference in stress perception was observed.

Conclusions: Varying trends and potential areas of intervention were identified for health behaviours in Hamburg. The comparison with Manchester students revealed differences in behaviours, which could be further explored to help inform health promotion strategies in both settings.
UV-Vis Spectrophotometric Analysis of DNA Retrieval for DNA Storage Applications
Authors: Minhas-Khan Aamir , Ghafar-Zadeh Morteza , Shaffaf Tina , Forouhi Saghi , Scime Anthony , Magierowski Sebastian , Ghafar-Zadeh Ebrahim
Published: September 2021

Informational Deoxyribonucleic Acid (iDNA) has gained the attention of many researchers and pioneer companies for the development of novel storage systems for the long-term and high-density storing of information. This research focuses on the physical storage of iDNA strands to address some of the current challenges by evaluating the accuracy of the process of iDNA retrieval from the surface after the dehydration process. For this aim, a UV-Vis spectrophotometric technique was used to measure the concentration of the DNA samples. Although spectroscopy has been widely employed for the evaluation of DNA concentration and contamination in a solution, it has not been used to investigate dry-state DNA, which is one of the preferred storage formats for the long-term retention of information. These results demonstrate that the UV-Vis spectrophotometric technique can be used to accurately measure dry-state DNA before the retrieval and its residues after the DNA retrieval process. This paper further examines the storage/retrieval process by investigating the relationship between the storage time and the amount of retrieved DNA or the DNA residue left on various surfaces. Based on the experimental results demonstrated and discussed in this paper, UV-Vis spectrophotometry can be used for monitoring dry-state DNA with a high accuracy larger than 98%. Moreover, these results reveal that the hydrophilicity and hydrophobicity of the surface do not significantly affect DNA retrieval over a one-month time period.
Optimal Attitude Maneuvering Analyses for Imaging at Squint Staring and Sliding Spotlight Modes of SAR Satellite
Authors: Kim Hongrae , Park Joonil , Chang Young-Keun , Lee Soo-Ho
Published: September 2021

In this study, we analyzed the imaging maneuver time, retargeting maneuver time, and attitude maneuvering characteristics in the imaging section (Phase 1) and retargeting maneuver section (Phase 2) when taking multiple-target images in squint spotlight mode in a single pass of a passive SAR satellite. In particular, the synthetic aperture time and attitude maneuvering characteristics in the staring and sliding spotlight modes that can image the wider swath width while maintaining high resolution were compared and analyzed. In the sliding spotlight mode, the rotation center was located below the ground surface when the satellite was maneuvering towards the target. Steering and sliding maneuvers were performed when targeting, and the synthetic aperture time of the sliding spotlight was longer than that of the staring spotlight because overlapping imaging was performed on the point target. The satellite maneuvering during imaging can be considered as a time-fixed problem, because it was performed within synthetic aperture time according to resolution, incidence angle, swath width, etc., by minimizing the Doppler centroid variation. In order to optimize the retargeting maneuver time, an optimal analysis of the attitude maneuvering was carried out and the validity of the optimal analysis algorithm was confirmed. Finally, the scenario was analyzed by assuming a problem of imaging four targets with 5 × 5 km swath width in a 20 km × 20 km densely populated area. It was confirmed that if a squint angle of ±12 degrees is provided in a single pass, four high resolution images of 5 km × 5 km can be imaged in the sliding spotlight mode.
Will the Adoption of Early Fertigation Techniques Hinder Famers’ Technology Renewal? Evidence from Fresh Growers in Shaanxi, China
Authors: Yuan Jiahong , Li Xiaoyu , Sun Zilai , Ruan Junhu
Published: September 2021

Fertigation technology is key to solve water pollution and inefficient fertilizer use. However, some early techniques cannot adapt to the current situation of labor shortages and large-scale planting. Therefore, it is necessary to consider farmers’ willingness to adopt more adaptive techniques. Specifically, we focus on whether early technology adoption will hinder technology renewal and whether the factors affecting the adoption of early and latest techniques are consistent. Through theoretical analysis and a survey, we find that farmers’ endowments such as income and labor force only affect the adoption intentions to the high-cost technique (Intelligent Irrigation Control System), but not early techniques (Venturi injector and Differential pressure tank), while farmers’ information processing ability and information acquisition channels affect both. Finally, the results of Propensity Score Matching show that early technology adoption will not become an obstacle to technology renewal.
Evolutionary Subdivision of Domestic Chickens: Implications for Local Breeds as Assessed by Phenotype and Genotype in Comparison to Commercial and Fancy Breeds
Authors: Larkina Tatyana A. , Barkova Olga Y. , Peglivanyan Grigoriy K. , Mitrofanova Olga V. , Dementieva Natalia V. , Stanishevskaya Olga I. , Vakhrameev Anatoly B. , Makarova Alexandra V. , Shcherbakov Yuri S. , Pozovnikova Marina V. , Brazhnik Evgeni A. , Griffin Darren K. , Romanov Michael N.
Published: September 2021

To adjust breeding programs for local, commercial, and fancy breeds, and to implement molecular (marker-assisted) breeding, a proper comprehension of phenotypic and genotypic variation is a sine qua non for breeding progress in animal production. Here, we investigated an evolutionary subdivision of domestic chickens based on their phenotypic and genotypic variability using a wide sample of 49 different breeds/populations. These represent a significant proportion of the global chicken gene pool and all major purposes of breed use (according to their traditional classification model), with many of them being characterized by a synthetic genetic structure and notable admixture. We assessed their phenotypic variability in terms of body weight, body measurements, and egg production. From this, we proposed a phenotypic clustering model (PCM) including six evolutionary lineages of breed formation: egg-type, meat-type, dual purpose (egg-meat and meat-egg), game, fancy, and Bantam. Estimation of genotypic variability was carried out using the analysis of five SNPs, i.e., at the level of genomic variation at the NCAPG-LCORL locus. Based on these data, two generally similar genotypic clustering models (GCM1 and GCM2) were inferred that also had several overlaps with PCM. Further research for SNPs associated with economically important traits can be instrumental in marker-assisted breeding programs.
Generic Relationships between Field Uses and Their Geographical Characteristics in Mountain-Area Dairy Cattle Farms
Authors: Sibra Cécile , Brunschwig Gilles
Published: September 2021

In mountain farms, challenges posed by the degree of land slope, altitude and harsh climate further compound multiple other possible constraints, particularly in relation to the distance of the farm from the farmstead. This study focused on how mountain-area dairy farmers factor the geographical characteristics of their fields into their field-use decisions. To that end, we surveyed 72 farmers who farm the traditional Salers breed of cattle and 28 specialised dairy system farmers in the central Massif region, France. Information was collected on the uses and geographical characteristics of all grassland fields (n = 2341) throughout the entire outdoor grazing season, without identifying farmers’ rationales for their field-use decisions. Field-use classes were constructed for the traditional Salers system per group of fields (grazed-only, cut-only, grazed-and-cut) and then used to classify fields in the specialized dairy system. The geographical characteristics, which were associated afterwards, were significantly different between the field groups and between field-use classes. Grazed-only fields were found to be more sloping and cut-only fields were smaller and further from the farmstead. Distance/area combinations were different according to field use (animal category, earliness of first cut, grazing and cutting sequence) and were decisive for all field-use classes. This study allowed the identification of generic relationships between field uses and their geographical characteristics in mountain-area dairy cattle farms.
Enhancing Grain Yield and Nitrogen Accumulation in Wheat Plants Grown under a Mediterranean Arid Environment by Foliar Spray with Papain-Released Whey Peptides
Authors: El-Sanatawy AbdAllah M. , Ash-Shormillesy Salwa M. A. I. , El-Yazied Ahmed Abou , El-Gawad Hany G. Abd , Azab Ehab , Gobouri Adil A. , Sitohy Mahmoud , Osman Ali
Published: September 2021

Due to their beneficial, stimulating impact on plant growth, productivity, and alleviating environmental stresses, protein hydrolysates have recently received increasing attention as a possible substitute. This investigation aimed to explore the effects of foliar application of papain-produced whey protein hydrolysates (WPH) on the yield attributes and nitrogen use efficiency (NUE) of soft wheat. Wheat plants were cultivated under a Mediterranean arid environment and received four soil nitrogen (N) fertilization levels with ammonium nitrate (145, 185, 215, and 250 kg N ha−1) and compared to control treatment and urea foliar application. WPH increased grain yield, yield attributes, and N accumulation in wheat plants. Partial productivity factors of applied nitrogen, as NUE indicators under relatively steady-state cropping systems, were also enhanced by WPH compared to control treatment. WPH significantly improved flag leaf area, spike number m−2, and grain yield compared to urea foliar application. Increasing the soil N fertilization level from 145 up to 215 kg N ha−1 was accompanied by significant increases in all yield traits and N accumulation measurements, except for the partial factor productivity of applied N, which decreased. A strong positive association was detected among grain and straw yields, their attributes, and total N uptake. Results highlighted the efficacy of WPH in increasing wheat yield and NUE.
Fermented Coffee Grounds Diminish Livestock Odors: A Microbiome Study
Authors: Kim Min-Sueng , Kim Sang-Ho , Jeong Minsoo , Park Min-Kyu , Jo YoungJae , Kang GI-Ung , Jung Da-Ryung , Lee Chang-Il , Shin Jae-Ho
Published: September 2021

Livestock odors are unavoidable problems in modern industrial society. We foresaw a role for fermented organic wastes in controlling odorous gases. In this study, we applied fermented coffee grounds to the floor area of a dairy cow barn and assessed alterations in odor compounds and a microbial shift over a period of three weeks. The treatment dramatically reduced ten odor compounds (more than 50%), highlighting the utility of fermented coffee grounds as an excellent product to reduce odors derived from cow manure. By the end of the treatment, the microbial consortium showed increases in rare families whose prevalence and abundance before the treatment had been low. Network analysis manifested 23 bacterial families dominant in fermented coffee grounds, negatively connected with odorous compounds, indicating potential odor-reducing bacterial families. This study provides an insight into using bacteria at the community level as a treatment to solve an environmental issue; simultaneously, it suggests proper usage of organic wastes by recycling them as fermenters for beneficial bacteria.
Development of the Technical Structure of the “Cow Energy” Concept
Authors: Bernhardt Heinz , Höhendinger Martin , Stumpenhausen Jörn
Published: September 2021

Regional energy supply is an important topic in the context of the energy transition in Germany. The “Cow Energy” project aims to combine the production of energy and milk for the farmer. In order to take the different needs into account, a central energy management system (EMS) is being established. This system records and simulates how much electricity is generated from renewable sources (biogas, solar, wind, etc.) on the farm. This is compared with the consumption of the barn technology (milking robot, feeding robot, etc.). This energy management is regulated according to the needs of the cows. In order to balance the fluctuations between energy production and energy consumption, the EMS regulates various battery systems. One goal is to network this energy system with the region and to establish regional energy networks.
Linear Relationship of a Soil Total Water Potential Function and Relative Yield—A Technique to Control Salinity and Water Stress on Golf Courses and Other Irrigated Fields
Authors: Beltrao Jose , Bekmirzaev Gulom , Ben Asher Jiftah , Costa Manuel , Panagopoulos Thomas
Published: September 2021

A simple empirical approach is proposed for the determination of crop relative yield (%) through the soil total water potential (kPa). Recurring to decimal logarithms, from analytical exponential expressions, a linear simple relationship of soil total water potential Ψt (matric Ψm + potential Ψo) function and crop relative yield was studied and developed. The combination of the salinity model, the soil water retention model and the matric potential approach were used to reach this objective. The representation of turfgrass crop relative yield (%) versus a function of soil total water potential f(Ψt) values was shown through a log-normal graph (y = a + mx); the log scale axis “y” (ordinates) defines relative yield Yr, being two the origin ordinate “a” and “m” the slope; the normal decimal scale axis “x” (abscissa) is the function of soil total water potential f(Ψt). Hence, it is possible, using only two experimental points, to define a simple linear relation between a function of soil total water potential and crop relative yield, for a soil matric potential value lower than −20 kPa. This approach was first tested on golf courses (perennial turfgrass fields), but it was further decided to extend it to other annual crop fields, focused on the model generalization. The experimental plots were established, respectively, in Algarve, Alentejo and Oeiras (Portugal) and in the North Negev (Israel). Sprinkler and trickle irrigation systems, under randomized blocks and/or water and salt gradient techniques, were used for water application with a precise irrigation water and salt distribution. Results indicated that there is a high agreement between the experimental and the prediction values (R2 = 0.92). Moreover, the precision of this very simple and easy tool applied to turfgrass fields and other irrigated soils, including their crop yields, under several different sites and climatic conditions, can contribute to its generalization.
Current Methods for the Extraction and Analysis of Isothiocyanates and Indoles in Cruciferous Vegetables
Authors: Karanikolopoulou Sofia , Revelou Panagiota-Kyriaki , Xagoraris Marinos , Kokotou Maroula G. , Constantinou-Kokotou Violetta
Published: September 2021

Cruciferous vegetables are characterized by the presence of sulfur-containing secondary plant metabolites known as glucosinolates (GLS). The consumption of cruciferous vegetables such as broccoli, cabbage, rocket salad, and cauliflower has been related to the prevention of non-communicable diseases. Their beneficial effects are attributed to the enzymatic degradation products of GLS, e.g., isothiocyanates and indoles. Owing to these properties, there has been a shift in the last few years towards the research of these compounds and a wide range of methods for their extraction and analytical determination have been developed. The aim of this review is to present the sample preparation and extraction procedures of isothiocyanates and indoles from cruciferous vegetables and the analytical methods for their determination. The majority of the references that have been reviewed are from the last decade. Although efforts towards the application of eco-friendly non-conventional extraction methods have been made, the use of conventional solvent extraction is mainly applied. The major analytical techniques employed for the qualitative and quantitative analysis of isothiocyanates and indoles are high-performance liquid chromatography and gas chromatography coupled with or without mass spectrometry detection. Nevertheless, the analytical determination of isothiocyanates presents several problems due to their instability and the absence of chromophores, making the simultaneous determination of isothiocyanates and indoles a challenging task.
The Role of Dietary and Microbial Fatty Acids in the Control of Inflammation in Neonatal Piglets
Authors: Metzler-Zebeli Barbara U.
Published: September 2021

Excessive inflammation and a reduced gut mucosal barrier are major causes for gut dysfunction in piglets. The fatty acid (FA) composition of the membrane lipids is crucial for mediating inflammatory signalling and is largely determined by their dietary intake. Porcine colostrum and milk are the major sources of fat in neonatal piglets. Both are rich in fat, demonstrating the dependence of the young metabolism from fat and providing the young organism with the optimum profile of lipids for growth and development. The manipulation of sow’s dietary polyunsaturated FA (PUFA) intake has been shown to be an efficient strategy to increase the transfer of specific FAs to the piglet for incorporation in enteric tissues and cell membranes. n-3 PUFAs, especially seems to be beneficial for the immune response and gut epithelial barrier function, supporting the piglet’s enteric defences in situations of increased stress such as weaning. Little is known about microbial lipid mediators and their role in gut barrier function and inhibition of inflammation in neonatal piglets. The present review summarizes the current knowledge of lipid nutrition in new-born piglets, comparing the FA ingestion from milk and plant-based lipid sources and touching the areas of host lipid signalling, inflammatory signalling and microbially derived FAs.
Ultrasound-Guided Radiofrequency Ablation of Chemodectomas in Five Dogs
Authors: Gómez Ochoa Pablo , Alférez María Dolores , de Blas Ignacio , Fernendes Telmo , Sánchez Salguero Xavier , Balañá Beatriz , Meléndez Lazo Antonio , Barbero Fernandez Alicia , Caivano Domenico , Corda Francesca , Corda Andrea
Published: September 2021

Chemodectomas are low prevalence tumors with complex clinical management. Many present as an incidental finding however, in other dogs, they produce pericardial effusion and/or compression, leading to the appearance of severe clinical signs. There are currently several approaches: surgery, radiotherapy, stent placement and chemotherapy. This is the first description of percutaneous echo-guided radiofrequency ablation of aortic body tumors. This minimally invasive treatment is based on high frequency alternating electrical currents from an electrode that produces ionic agitation and generates frictional heat, causing coagulation necrosis. Five dogs with an echocardiographic and cytological diagnosis of chemodectoma underwent percutaneous echo-guided radiofrequency ablation. At the time of presentation, all the dogs showed clinical signs, such as ascites and/or collapse. There were no complications either during the procedure or in the following 24 hours. Rapid clinical improvement associated with a reduction in size and change in sonographic appearance of the mass were achieved with no complications. Six months follow-up was carried out in all dogs. A second percutaneous echo-guided RFA was performed eight months after the first procedure in one dog. Based on our experience, radiofrequency ablation seems to be a feasible and safe technique, making it a potential alternative therapeutic approach in the clinical management of aortic body tumors leading to severe clinical compromise.
Enhancing Growth Performance, Organ Development, Meat Quality, and Bone Mineralisation of Broiler Chickens through Multi-Enzyme Super-Dosing in Reduced Energy Diets
Authors: Bromfield Jacoba I. , Hoffman Louwrens C. , Horyanto Darwin , Soumeh Elham A.
Published: September 2021

This study identified the optimal multi-enzyme dose rate at three energy levels based on the production performance of broiler chickens. A 42-day grow out trial was conducted using 576 day-old mixed-sex ROSS308 broiler chickens in a 3 × 4 factorial arrangement in a completely randomized design. Diets consisting of three metabolizable energy (ME) levels: standard energy (STD), 150 kcal/kg energy reduction (STD-150), and 200 kcal/kg energy reduction (STD-200), were cross factored with four multi-enzyme inclusion levels (0, 350, 700, and 1000 g/ton). The average daily feed intake and feed conversion ratio increased linearly (p < 0.001) as the dietary ME was reduced, and the multi-enzyme addition improved the feed conversion ratio (p < 0.05) and mitigated the negative effect of the reduced energy diets (RED) on feed intake and feed conversion ratios. Carcass composition, organ weights, and meat quality were not affected by the experimental diets. The RED decreased abdominal fat weight (p < 0.05). Total ash, calcium, and phosphorous contents of the tibia bone were improved (p < 0.04) when the RED were supplemented with the multi-enzyme. Super-dosing multi-enzymes in RED mitigates the negative effect of ME reduction on growth performance while maintaining organ development and meat quality and improving bone mineral content.
From Anti-SARS-CoV-2 Immune Response to the Cytokine Storm via Molecular Mimicry
Authors: Kanduc Darja
Published: September 2021

The aim of this study was to investigate the role of molecular mimicry in the cytokine storms associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human proteins endowed with anti-inflammatory activity were assembled and analyzed for peptide sharing with the SARS-CoV-2 spike glycoprotein (gp) using public databases. It was found that the SARS-CoV-2 spike gp shares numerous pentapeptides with anti-inflammatory proteins that, when altered, can lead to cytokine storms characterized by diverse disorders such as systemic multiorgan hyperinflammation, macrophage activation syndrome, ferritinemia, endothelial dysfunction, and acute respiratory syndrome. Immunologically, many shared peptides are part of experimentally validated epitopes and are also present in pathogens to which individuals may have been exposed following infections or vaccinal routes and of which the immune system has stored memory. Such an immunologic imprint might trigger powerful anamnestic secondary cross-reactive responses, thus explaining the raging of the cytokine storm that can occur following exposure to SARS-CoV-2. In conclusion, the results support molecular mimicry and the consequent cross-reactivity as a potential mechanism in SARS-CoV-2-induced cytokine storms, and highlight the role of immunological imprinting in determining high-affinity, high-avidity, autoimmune cross-reactions as a pathogenic sequela associated with anti-SARS-CoV-2 vaccines.
Beta-Lactams Dosing in Critically Ill Patients with Gram-Negative Bacterial Infections: A PK/PD Approach
Authors: Maguigan Kelly L. , Al-Shaer Mohammad H. , Peloquin Charles A.
Published: September 2021

Beta-lactam antibiotics are often the backbone of treatment for Gram-negative infections in the critically ill. Beta-lactams exhibit time-dependent killing, and their efficacy depends on the percentage of dosing interval that the concentration remains above the minimum inhibitory concentration. The Gram-negative resistance rates of pathogens are increasing in the intensive care unit (ICU), and critically ill patients often possess physiology that makes dosing more challenging. The volume of distribution is usually increased, and drug clearance is variable. Augmented renal clearance and hypermetabolic states increase the clearance of beta-lactams, while acute kidney injury reduces the clearance. To overcome the factors affecting ICU patients and decreasing susceptibilities, dosing strategies involving higher doses, and extended or continuous infusions may be required. In this review, we specifically examined pharmacokinetic models in ICU patients, to determine the desired beta-lactam regimens for clinical breakpoints of Enterobacterales and Pseudomonas aeruginosa, as determined by the European Committee on Antimicrobial Susceptibility Testing. The beta-lactams evaluated included penicillins, cephalosporins, carbapenems, and monobactams. We found that when treating less-susceptible pathogens, especially P. aeruginosa, continuous infusions are frequently needed to achieve the desired pharmacokinetic/pharmacodynamic targets. More studies are needed to determine optimal dosing strategies in the novel beta-lactams.
Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells
Authors: Zhu Jiaqi , Langer Peter , Ulrich Claas , Eberle Jürgen
Published: September 2021

Efficient drugs are needed for countering the worldwide high incidence of cutaneous squamous cell carcinoma (cSCC) and actinic keratosis. Indirubin derivatives represent promising candidates, but their effects in cSCC cells have not been reported before. Here, we investigated the efficacy of three indirubin derivatives (DKP-071, -073 and -184) in four cSCC cell lines. High efficacy was seen in SCL-I, SCL-II, SCC-12 and SCC-13, resulting in up to 80% loss of cell proliferation, 60% loss of cell viability and 30% induced apoptosis (10 µM). Apoptosis was further enhanced in combinations with TNF-related apoptosis-inducing ligand (TRAIL). Induction of reactive oxygen species (ROS) appeared as critical for these effects. Thus, antioxidative pretreatment completely abolished apoptosis as well as restored cell proliferation and viability. Concerning the pathways, complete activation of caspases cascades (caspases-3, -4, -6, -7, -8 and -9), loss of mitochondrial membrane potential, activation of proapoptotic PKCδ (protein kinase C delta), inhibition of STAT3 (signal transducer and activator of transcription 3), downregulation of antiapoptotic XIAP (X-linked inhibitor of apoptosis protein) and survivin as well as upregulation of the proapoptotic Bcl-2 protein Puma and the cell cycle inhibitor p21 were obtained. Importantly, all activation steps were prevented by antioxidants, thus proving ROS as a master regulator of indirubins’ antitumor effects. ROS induction presently develops as an important issue in anticancer therapy.
The Conformity of Rehabilitation Protocols Used for Different Cartilage Repairs of the Knee Joint—A Review on Rehabilitation Standards in German Speaking Countries
Authors: Memmel Clemens , Krutsch Werner , Koch Matthias , Riedl Moritz , Henssler Leopold , Zeman Florian , Knorr Christian , Alt Volker , Pfeifer Christian
Published: September 2021

The present study analysed current rehabilitation protocols to investigate whether there is a standard for early rehabilitation after microfracturing (MFX), matrix-assisted cartilage transplantation (MACT), and osteochondral autograft transfer (OATS) of the knee joint in clinical routine, and if rehabilitation protocols differ in the repair technique used or the localization of the cartilage defect. The evaluation included rehabilitation criteria such as weight-bearing, range of motion, use of an orthosis, motion therapy, and rehabilitation training during the early rehabilitation phase after MFX, MACT, and OATS of the femorotibial and retropatellar joint space. We analysed 153 rehabilitation protocols after cartilage repair of the knee joint, including 137 protocols for after repair of the main weight-bearing (femorotibial) area and 16 for after retropatellar cartilage repair. Most of the protocols differed significantly according to the location of the repair and the procedure performed. Our findings indicate that full weight-bearing can be achieved significantly faster after MFX (5.6 weeks) and OATS (5.3 weeks) than after MACT of the main weight-bearing zone (6.6 weeks, p < 0.001). In addition, after retropatellar cartilage repair, patients are allowed full weight-bearing after 2.1 weeks compared to the main weight-bearing zone (5.3–6.6 weeks; p < 0.001). No standardized rehabilitation recommendations have been established. The present study shows that rehabilitation needs to be adjusted to the surgical technique and the location of the defect zone, and further investigation is warranted to establish standardized rehabilitation protocols after cartilage repair of the knee joint.
A Digital Twin Architecture to Optimize Productivity within Controlled Environment Agriculture
Authors: Chaux Jesus David , Sanchez-Londono David , Barbieri Giacomo
Published: September 2021

To ensure food security, agricultural production systems should innovate in the direction of increasing production while reducing utilized resources. Due to the higher level of automation with respect to traditional agricultural systems, Controlled Environment Agriculture (CEA) applications generally achieve better yields and quality crops at the expenses of higher energy consumption. In this context, Digital Twin (DT) may constitute a fundamental tool to reach the optimization of the productivity, intended as the ratio between production and resource consumption. For this reason, a DT Architecture for CEA systems is introduced within this work and applied to a case study for its validation. The proposed architecture is potentially able to optimize productivity since it utilizes simulation software that enables the optimization of: (i) Climate control strategies related to the control of the crop microclimate; (ii) treatments related to crop management. Due to the importance of food security in the worldwide landscape, the authors hope that this work may impulse the investigation of strategies for improving the productivity of CEA systems.
Influence of the Flexible Tower on Aeroelastic Loads of the Wind Turbine
Authors: Hao Junbo , Wang Zedong , Yi Wenwu , Chen Yan , Chen Jiyao
Published: September 2021

The finite element discretization of a tower system based on the two-node Euler-Bernoulli beam is carried out by taking the cubic Hermite polynomial as the form function of the beam unit, calculating the structural characteristic matrix of the tower system, and establishing the wind turbine-nacelle-tower multi-degree-of-freedom finite element numerical model. The equation for calculating the aerodynamic load for any nacelle attitude angle is derived. The effect of the flexible tower vibration feedback on the aerodynamic load of the wind turbine is studied. The results show that, when the stiffness of the tower is large, the effect of having tower vibration feedback or not on the aeroelastic load of the wind turbine is small. For the more flexible tower system, wind-induced vibration time-varying feedback will cause larger aeroelastic load variations, especially the top of the tower overturning moment, thus causing a larger impact on the dynamic behavior of the tower downwind and crosswind. As the flexibility of the tower system increases, the interaction between tower vibration and pneumatic load is also gradually increasing. Taking into account the influence of flexible towers on the aeroelastic load of a wind turbine can help predict the pneumatic load of a wind turbine more accurately and improve the efficiency of wind energy utilization on the one hand and analyze the dynamic behavior of the flexible structure of a wind turbine more accurately on the other hand, which is extremely beneficial to the structural optimization of wind turbine.
The Synthesis of Aluminum Matrix Composites Reinforced with Fe-Al Intermetallic Compounds by Ball Milling and Consolidation
Authors: Díaz Roberto Ademar Rodríguez , Segura Sergio Rubén Gonzaga , Barragán José Luis Reyes , Vázquez Víctor Ravelero , Ocampo Arturo Molina , Calderón Jesús Porcayo , Mejía Héctor Cruz , Rodríguez Carlos Alberto González , Fierro Jesús Israel Barraza
Published: September 2021

In this study, a nano-composite material of a nanostructured Al-based matrix reinforced with Fe40Al intermetallic particles was produced by ball milling. During the non-equilibria processing, the powder mixtures with the compositions of Al-XFe40Al (X = 5, 10, and 15 vol. %) were mechanically milled under a low energy regime. The processed Al-XFe40Al powder mixtures were subjected to uniaxial pressing at room temperature. Afterward, the specimens were subjected to a sintering process under an inert atmosphere. In this thermal treatment, the specimens were annealed at 500 °C for 2 h. The sintering process was performed under an argon atmosphere. The crystallite size of the Al decreased as the milling time advanced. This behavior was observed in the three specimens. During the ball milling stage, the powder mixtures composed of Al-XFe40Al did not experience a mechanochemical reaction that could lead to the generation of secondary phases. The crystallite size of the Al displayed a predominant tendency to decrease during the ball milling process. The microstructure of the consolidated specimens indicated a uniform dispersion of the intermetallic reinforcement phases in the Al matrix. Moreover, according to the Vickers microhardness tests, the hardness varied linearly with the increase in the concentration of the Fe40Al intermetallic phase present in the composite material. The presented graphs indicate that the hardness increased almost linearly with the increasing dislocation density and with the reduction in grain sizes (both occurring during the non-equilibria processing). The microstructural and mechanical properties reported in this paper provide the aluminum matrix composite materials with the ideal conditions to be considered candidates for applications in the automotive and aeronautical industries.
Design Study for a New Spanner
Authors: Lin Ming-Che , Ho Tsung-Han
Published: September 2021

A replacement for the original F-spanner is designed using computer-aided engineering (CAE) and the Taguchi method. In the design process, the L9(34) orthogonal table was used for parameter design. Four control factors are used: outer diameter, bend radius, angle, and connected fillet. Each factor is set to three levels with numerical analysis using ANSYS software. After performing an optimization analysis for the combination parameters, the prototype is created by rapid-prototyping (RP) and is found to improve operational safety in a piping system.