bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge of Medical Students and Medical Professionals Regarding Nutritional Deficiencies in Patients with Celiac Disease
Authors: Dembiński Łukasz , Mazur Artur , Dąbrowski Mariusz , Jackowska Teresa , Banaszkiewicz Aleksandra
Published: May 2021

A gluten-free diet provides relief from symptoms for patients with celiac disease, although there is still a risk of nutritional deficiencies. These patients can potentially consume an excessive amount of fat and insufficient amounts of fiber, iron, vitamin D, and calcium. This study aimed to assess the knowledge of medical students and healthcare professionals in Poland regarding nutritional deficiencies and the prevention of such deficiencies in patients with celiac disease who are on a gluten-free diet. Of the 430 survey participants, 46% did not realize the risk of nutritional deficiencies in patients with celiac disease. The knowledge of the participants was lowest regarding the risk of being overweight or obese. Among the healthcare professionals, an acceptable level of correct answers was provided by only 37% of individuals and was highest for the dietitians’ group. Our results demonstrate the need to improve the education of healthcare professionals concerning nutrition in patients with celiac disease.
Sugar-Sweetened Beverage Consumption and Calcified Atherosclerotic Plaques in the Coronary Arteries: The NHLBI Family Heart Study
Authors: Patel Yash R. , Imran Tasnim F. , Ellison R. Curtis , Hunt Steven C. , Carr John Jeffrey , Heiss Gerardo , Arnett Donna K. , Pankow James S. , Gaziano J. Michael , Djoussé Luc
Published: May 2021

Background: Sugar-sweetened beverage (SSB) intake is associated with higher risk of weight gain, diabetes, hypertension, cardiovascular disease, and cardiovascular mortality. However, the association of SSB with subclinical atherosclerosis in the general population is unknown. Objective: Our primary objective was to investigate the association between SSB intake and prevalence of atherosclerotic plaque in the coronary arteries in The National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Methods: We studied 1991 participants of the NHLBI Family Heart Study without known coronary heart disease. Intake of SSB was assessed through a semi-quantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac Computed Tomography (CT) and prevalent CAC was defined as an Agatston score ≥100. We used generalized estimating equations to calculate adjusted prevalence ratios of CAC. A sensitivity analysis was also performed at different ranges of cut points for CAC. Results: Mean age and body mass index (BMI) were 55.0 years and 29.5 kg/m2, respectively, and 60% were female. In analysis adjusted for age, sex, BMI, smoking, alcohol use, physical activity, energy intake, and field center, higher SSB consumption was not associated with higher prevalence of CAC [prevalence ratio (95% confidence interval) of: 1.0 (reference), 1.36 (0.70–2.63), 1.69 (0.93–3.09), 1.21 (0.69–2.12), 1.05 (0.60–1.84), and 1.58 (0.85–2.94) for SSB consumption of almost never, 1–3/month, 1/week, 2–6/week, 1/day, and ≥2/day, respectively (p for linear trend 0.32)]. In a sensitivity analysis, there was no evidence of association between SSB and prevalent CAC when different CAC cut points of 0, 50, 150, 200, and 300 were used. Conclusions: These data do not provide evidence for an association between SSB consumption and prevalent CAC in adult men and women.
Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes
Authors: Lee Minwoo , Lim Jae-Sung , Kim Yerim , Lee Ju Hun , Kim Chul-Ho , Lee Sang-Hwa , Jang Min Uk , Oh Mi Sun , Lee Byung-Chul , Yu Kyung-Ho
Published: May 2021

Background: It is not yet clear whether nutritional status is associated with post-stroke cognitive impairment (PSCI). We examined the geriatric nutritional risk index (GNRI) on the domain-specific cognitive outcomes 3 months after a stroke. Methods: A total of 344 patients with acute ischemic stroke were included for the analysis. The GNRI was calculated as 1.489 × serum albumin (g/L) + 41.7 × admission weight (kg)/ideal body weight (kg) and was dichotomized according to the prespecified cut-off points for no risk and any risks. The primary outcome was PSCI, defined as having adjusted z-scores of less than −2 standard deviations in at least one cognitive domain: executive/activation, memory, visuospatial and language. Multiple logistic regression and linear regression analyses were performed to investigate the association between the GNRI and cognitive outcomes. Results: Seventy (20.3%) patients developed PSCI 3 months after a stroke. The mean GNRI was 106.1 ± 8.6, and 59 (17.2%) patients had low (<98) GNRI scores. A low GNRI was independently associated with the PSCI after adjusting for age, sex, education, initial stroke severity, stroke mechanism and left hemispheric lesion (odds ratio, 2.04; 95% confidence interval, 1.00–4.14). The GNRI scores were also significantly associated with the z-scores from the mini-mental status examination and the frontal domain (β = 0.04, p-value = 0.03; β = 0.03, p-value = 0.03, respectively). Conclusions: A low GNRI was independently associated with the development of PSCI at 3 months after an ischemic stroke. The GNRI scores were specifically associated with the z-scores of the global cognition and frontal domain cognitive outcomes.
Social Media Mining for an Analysis of Nutrition and Dietary Health in Taiwan
Authors: Hsieh Yu-Lun , Chang Yung-Chun , Chang Wei-Yu
Published: May 2021

Dining is an essential part of human life. In order to pursue a healthier self, more and more people enjoy homemade cuisines. Consequently, the amount of recipe websites has increased significantly. These online recipes represent different cultures and cooking methods from various regions, and provide important indications on nutritional content. In recent years, the development of data science made data mining a popular research area. However, only a few researches in Taiwan have applied data mining in the studies of recipes and nutrients. Therefore, this work aims at utilizing machine learning models to discover health-related insights from recipes on social media. First, we collected over 15,000 Chinese recipes from the largest recipe website in Taiwan to build a recipe database. We then extracted information from this dataset through natural language processing methodologies so as to better understand the characteristics of various cuisines and ingredients. Thus, we can establish a classification model for the automatic categorization of recipes. We further performed cluster analysis for grouping nutrients to recognize the nutritional differences for each cluster and each cuisine type. The results showed that using the support vector machine (SVM) model can successfully classify recipes with an average F-score of 82%. We also analyzed the nutritional value of different cuisine categories and the possible health effects they may bring to the consumers. Our methods and findings can assist future work on extracting essential nutritional information from recipes and promoting healthier diets.
The Microbiome as a Therapy in Pouchitis and Ulcerative Colitis
Authors: LeBlanc Jean-Frédéric , Segal Jonathan P. , de Campos Braz Lucia Maria , Hart Ailsa L.
Published: May 2021

The gut microbiome has been implicated in a range of diseases and there is a rapidly growing understanding of this ecosystem’s importance in inflammatory bowel disease. We are yet to identify a single microbe that causes either ulcerative colitis (UC) or pouchitis, however, reduced microbiome diversity is increasingly recognised in active UC. Manipulating the gut microbiome through dietary interventions, prebiotic and probiotic compounds and faecal microbiota transplantation may expand the therapeutic landscape in UC. Specific diets, such as the Mediterranean diet or diet rich in omega-3 fatty acids, may reduce intestinal inflammation or potentially reduce the risk of incident UC. This review summarises our knowledge of gut microbiome therapies in UC and pouchitis.
Using Spectator Matter for Centrality Determination in Nucleus-Nucleus Collisions
Authors: Svetlichnyi Aleksandr , Nepeyvoda Roman , Pshenichnov Igor
Published: May 2021

One of the common methods to measure the centrality of nucleus-nucleus collision events consists of detecting forward spectator neutrons. Because of non-monotonic dependence of neutron numbers on centrality, other characteristics of spectator matter in 197Au–197Au collisions at NICA must be considered to improve the centrality determination. The numbers of spectator deuterons and α-particles and the forward–backward asymmetry of the numbers of free spectator nucleons were calculated with the Abrasion–Ablation Monte Carlo for Colliders (AAMCC) model as functions of event centrality. It was shown that the number of charged fragments per spectator nucleon decreases monotonically with an increase of the impact parameter, and thus can be used to estimate the collision centrality. The conditional probabilities that a given event with specific spectator characteristics belongs to a certain centrality class were calculated by means of AAMCC. Such probabilities can be used as an input to Bayesian or other machine-learning approaches to centrality determination in 197Au–197Au collisions.
Epigenetic Mechanisms Involved in Cisplatin-Induced Nephrotoxicity: An Update
Authors: Loren Pía , Saavedra Nicolás , Saavedra Kathleen , Zambrano Tomás , Moriel Patricia , Salazar Luis A.
Published: May 2021

Cisplatin is an antineoplastic drug used for the treatment of many solid tumors. Among its various side effects, nephrotoxicity is the most detrimental. In recent years, epigenetic regulation has emerged as a modulatory mechanism of cisplatin-induced nephrotoxicity, involving non-coding RNAs, DNA methylation and histone modifications. These epigenetic marks alter different signaling pathways leading to damage and cell death. In this review, we describe how different epigenetic modifications alter different pathways leading to cell death by apoptosis, autophagy, necroptosis, among others. The study of epigenetic regulation is still under development, and much research remains to fully determine the epigenetic mechanisms underlying cell death, which will allow leading new strategies for the diagnosis and therapy of this disease.
New Nanomaterials with Intrinsic Antioxidant Activity by Surface Functionalization of Niosomes with Natural Phenolic Acids
Authors: Mazzotta Elisabetta , Orlando Carla , Muzzalupo Rita
Published: May 2021

Nanoantioxidants have emerged as smart devices able to provide improved stability and biocompatibility and sustained and targeted release of conventional antioxidants. In the current research, a new family of nanoantioxidants has been developed by covalently grafting gallic (GA), caffeic (CF) and ferulic (FR) acid on the surfaces of Tween 80 niosomes. First, empty and curcumin (CUR)-loaded vesicles were prepared using a thin-layer evaporation technique and then functionalized with phenolic acids using carbodiimide chemistry. Nanoantioxidants obtained were characterized in terms of size, polydispersity index, zeta potential, and loading efficiency. Their antioxidant activity was studied by ABTS and DPPH assays. Surface functionalization of empty and CUR-loaded vesicles provided stable vesicles with intrinsic antioxidant properties. In vitro antioxidant assays highlighted that vesicles functionalized with FR or GA exhibited better antioxidant activity compared to CF-grafted niosomes. Furthermore, vesicles loaded with CUR and functionalized with GA and CF showed an enhanced scavenging ability of ABTS and DPPH radicals, compared to the single antioxidant-loaded formulations, highlighting an important synergic effect of CUR when used in combination with GA ad CF.
Solubility Enhancement of Ibuprofen by Adsorption onto Spherical Porous Calcium Silicate
Authors: Kawano Yayoi , Chen Shiyang , Hanawa Takehisa
Published: May 2021

The solubility of a drug is higher when it is in an amorphous form than when it is in a crystalline form. To enhance the solubility of ibuprofen (IBU), a poorly water-soluble drug, we attempted to adsorb IBU onto spherical porous calcium silicate (Florite® PS300, PS300) in two ways: the evaporation (EV) and sealed heating (SH) methods. The crystallinity of the samples was evaluated using powder X-ray diffraction analysis (PXRD) and differential scanning calorimetry (DSC). The molecular interaction between IBU and PS300 was evaluated with FTIR. In addition, the dissolution behavior of IBU in the samples was assessed by the dissolution test. Based on the results of the PXRD and DSC measurements, both methods allowed adsorption of IBU onto PS300, and IBU was amorphized. Based on the FTIR observations, in the SH or EV mixtures containing 10% and 30% IBU, respectively, it seemed that the IBU molecules intermolecularly interacted with calcium molecules as the main component of PS300. Improvement in the solubility of IBU was observed with both methods; however, the dissolution rate of IBU from samples prepared via SH was higher than that from EV, or of IBU crystals. Collectively, our findings indicate that the petal-like structure of PS300, which has a spherical shape and good flowability, is an effective tool for adsorbing IBU onto PS300 via SH.
Assessment of Metabolic Interaction between Repaglinide and Quercetin via Mixed Inhibition in the Liver: In Vitro and In Vivo
Authors: Kim Ji-Min , Seo Seong-Wook , Han Dong-Gyun , Yun Hwayoung , Yoon In-Soo
Published: May 2021

Repaglinide (RPG), a rapid-acting meglitinide analog, is an oral hypoglycemic agent for patients with type 2 diabetes mellitus. Quercetin (QCT) is a well-known antioxidant and antidiabetic flavonoid that has been used as an important ingredient in many functional foods and complementary medicines. This study aimed to comprehensively investigate the effects of QCT on the metabolism of RPG and its underlying mechanisms. The mean (range) IC50 of QCT on the microsomal metabolism of RPG was estimated to be 16.7 (13.0–18.6) μM in the rat liver microsome (RLM) and 3.0 (1.53–5.44) μM in the human liver microsome (HLM). The type of inhibition exhibited by QCT on RPG metabolism was determined to be a mixed inhibition with a Ki of 72.0 μM in RLM and 24.2 μM in HLM as obtained through relevant graphical and enzyme inhibition model-based analyses. Furthermore, the area under the plasma concentration versus time curve (AUC) and peak plasma concentration (Cmax) of RPG administered intravenously and orally in rats were significantly increased by 1.83- and 1.88-fold, respectively, after concurrent administration with QCT. As the protein binding and blood distribution of RPG were observed to be unaltered by QCT, it is plausible that the hepatic first-pass and systemic metabolism of RPG could have been inhibited by QCT, resulting in the increased systemic exposure (AUC and Cmax) of RPG. These results suggest that there is a possibility that clinically significant pharmacokinetic interactions between QCT and RPG could occur, depending on the extent and duration of QCT intake from foods and dietary supplements.
On the Evolution of the Biological Framework for Insight
Authors: Neidhöfer Claudio
Published: May 2021

The details of abiogenesis, to date, remain a matter of debate and constitute a key mystery in science and philosophy. The prevailing scientific hypothesis implies an evolutionary process of increasing complexity on Earth starting from (self-) replicating polymers. Defining the cut-off point where life begins is another moot point beyond the scope of this article. We will instead walk through the known evolutionary steps that led from these first exceptional polymers to the vast network of living biomatter that spans our world today, focusing in particular on perception, from simple biological feedback mechanisms to the complexity that allows for abstract thought. We will then project from the well-known to the unknown to gain a glimpse into what the universe aims to accomplish with living matter, just to find that if the universe had ever planned to be comprehended, evolution still has a long way to go.
Particle-in-Cell Simulations of High-Power THz Generator Based on the Collision of Strongly Focused Relativistic Electron Beams in Plasma
Authors: Annenkov Vladimir , Berendeev Evgeny , Volchok Evgeniia , Timofeev Igor
Published: May 2021

Based on particle-in-cell simulations, we propose to generate sub-nanosecond pulses of narrowband terahertz radiation with tens of MW power using unique properties of kiloampere relativistic (2 MeV) electron beams produced by linear induction accelerators. Due to small emittance of such beams, they can be focused into millimeter and sub-millimeter spots comparable in sizes with the wavelength of THz radiation. If such a beam is injected into a plasma, it becomes unstable against the two-stream instability and excites plasma oscillations that can be converted to electromagnetic waves at the plasma frequency and its harmonics. It is shown that several radiation mechanisms with high efficiency of power conversion (∼1%) come into play when the radial size of the beam–plasma system becomes comparable with the wavelength of the emitted waves.
Three-Dimensional Laser Imaging with a Variable Scanning Spot and Scanning Trajectory
Authors: Yang Ao , Cao Jie , Cheng Yang , Chen Chuanxun , Hao Qun
Published: May 2021

Traditional lidar scans the target with a fixed-size scanning spot and scanning trajectory. Therefore, it can only obtain the depth image with the same pixels as the number of scanning points. In order to obtain a high-resolution depth image with a few scanning points, we propose a scanning and depth image reconstruction method with a variable scanning spot and scanning trajectory. Based on the range information and the proportion of the area of each target (PAET) contained in the multi echoes, the region with multi echoes (RME) is selected and a new scanning trajectory and smaller scanning spot are used to obtain a finer depth image. According to the range and PAET obtained by scanning, the RME is segmented and filled to realize the super-resolution reconstruction of the depth image. By using this method, the experiments of two overlapped plates in space are carried out. By scanning the target with only forty-three points, the super-resolution depth image of the target with 160 × 160 pixels is obtained. Compared with the real depth image of the target, the accuracy of area representation (AOAR) and structural similarity (SSIM) of the reconstructed depth image is 99.89% and 98.94%, respectively. The method proposed in this paper can effectively reduce the number of scanning points and improve the scanning efficiency of the three-dimensional laser imaging system.
Fourier Convolution Operation on Metasurface-Based Hologram in Microwave Region
Authors: Yang Shuai , Guan Chunsheng , Ding Xumin , Zhang Kuang , Burokur Shah Nawaz , Wu Qun
Published: May 2021

In this paper, a 0.1λ0-thick 1-bit coding metasurface is proposed to achieve a polarization-insensitive hologram under oblique incidence, utilizing compact ground-backed patch unit cells. Fourier convolution theory in a digital signal processing system is added to the hologram calculation of the improved weighted Gerchberg–Saxton (GSW) algorithm to achieve control of the scattered pattern in the microwave region. As a proof of concept, a prototype operating at 15 GHz is designed to verify the validity of our proposed approach. The measured performances show good imaging quality under different incident polarizations, providing potential applications in imaging processing and information storage.
Computational Method for Wavefront Sensing Based on Transport-of-Intensity Equation
Authors: Gritsenko Iliya , Kovalev Michael , Krasin George , Konoplyov Matvey , Stsepuro Nikita
Published: May 2021

Recently the transport-of-intensity equation as a phase imaging method turned out as an effective microscopy method that does not require the use of high-resolution optical systems and a priori information about the object. In this paper we propose a mathematical model that adapts the transport-of-intensity equation for the purpose of wavefront sensing of the given light wave. The analysis of the influence of the longitudinal displacement z and the step between intensity distributions measurements on the error in determining the wavefront radius of curvature of a spherical wave is carried out. The proposed method is compared with the traditional Shack–Hartmann method and the method based on computer-generated Fourier holograms. Numerical simulation showed that the proposed method allows measurement of the wavefront radius of curvature with radius of 40 mm and with accuracy of ~200 μm.
Polydioxanone-Based Membranes for Bone Regeneration
Authors: Saska Sybele , Pilatti Livia , Silva Edvaldo Santos de Sousa , Nagasawa Magda Aline , Câmara Diana , Lizier Nelson , Finger Eduardo , Dyszkiewicz Konwińska Marta , Kempisty Bartosz , Tunchel Samy , Blay Alberto , Shibli Jamil Awad
Published: May 2021

Resorbable synthetic and natural polymer-based membranes have been extensively studied for guided tissue regeneration. Alloplastic biomaterials are often used for tissue regeneration due to their lower immunoreactivity when compared with allogeneic and xenogeneic materials. Plenum® Guide is a synthetic membrane material based on polydioxanone (PDO), whose surface morphology closely mimics the extracellular matrix. In this study, Plenum® Guide was compared with collagen membranes as a barrier material for bone-tissue regeneration in terms of acute and subchronic systemic toxicity. Moreover, characterizations such as morphology, thermal analysis (Tm = 107.35 °C and crystallinity degree = 52.86 ± 2.97 %, final product), swelling (thickness: 0.25 mm ≅ 436% and 0.5 mm ≅ 425% within 24 h), and mechanical tests (E = 30.1 ± 6.25 MPa; σ = 3.92 ± 0.28 MPa; ε = 287.96 ± 34.68%, final product) were performed. The in vivo results revealed that the PDO membranes induced a slightly higher quantity of newly formed bone tissue than the control group (score: treated group = 15, control group = 13) without detectable systemic toxicity (clinical signs and evaluation of the membranes after necropsy did not result in differences between groups, i.e., non-reaction -> tissue-reaction index = 1.3), showing that these synthetic membranes have the essential characteristics for an effective tissue regeneration. Human adipose-derived stem cells (hASCs) were seeded on PDO membranes; results demonstrated efficient cell migration, adhesion, spread, and proliferation, such that there was a slightly better hASC osteogenic differentiation on PDO than on collagen membranes. Hence, Plenum® Guide membranes are a safe and efficient alternative for resorbable membranes for tissue regeneration.
Synthesis and Polymerization Kinetics of Rigid Tricyanate Ester
Authors: Galukhin Andrey , Nosov Roman , Nikolaev Ilya , Melnikova Elena , Islamov Daut , Vyazovkin Sergey
Published: May 2021

A new rigid tricyanate ester consisting of seven conjugated aromatic units is synthesized, and its structure is confirmed by X-ray analysis. This ester undergoes thermally stimulated polymerization in a liquid state. Conventional and temperature-modulated differential scanning calorimetry techniques are employed to study the polymerization kinetics. A transition of polymerization from a kinetic- to a diffusion-controlled regime is detected. Kinetic analysis is performed by combining isoconversional and model-based computations. It demonstrates that polymerization in the kinetically controlled regime of the present monomer can be described as a quasi-single-step, auto-catalytic, process. The diffusion contribution is parameterized by the Fournier model. Kinetic analysis is complemented by characterization of thermal properties of the corresponding polymerization product by means of thermogravimetric and thermomechanical analyses. Overall, the obtained experimental results are consistent with our hypothesis about the relation between the rigidity and functionality of the cyanate ester monomer, on the one hand, and its reactivity and glass transition temperature of the corresponding polymer, on the other hand.
Extraction and Physicochemical Characterization of Dried Powder Mucilage from Opuntia ficus-indica Cladodes and Aloe Vera Leaves: A Comparative Study
Authors: Otálora María Carolina , Wilches-Torres Andrea , Castaño Jovanny A. Gómez
Published: May 2021

Cactaceae and Asphodelaceae are native desert plants known for their high mucilage content, which is a polysaccharide of growing interest in the food, cosmetic, and pharmaceutical industries. In this study, powdered mucilage was obtained from cladodes of Opuntia ficus-indica (OFI) and aloe vera (AV) leaves, and their molecular, morphological, and thermal properties were investigated and compared. Additionally, their dietary fiber content was determined. Three-dimensional molecular models were calculated for both mucilages using ab initio methods. Vibrational spectra (FTIR and Raman) revealed intramolecular interactions and functional groups that were specified with the help of theoretical ab initio and semi-empirical calculations. SEM micrographs measured at magnifications of 500× and 2000× demonstrated significantly different superficial and internal morphologies between these two mucilages. Thermal analysis using DSC/TGA demonstrated superior thermal stability for the OFI mucilage. The dietary fiber content in OFI mucilage was more than double that of AV mucilage. Our results show that both dehydrated mucilages present adequate thermal and nutritional properties to be used as functional ingredients in industrial formulations; however, OFI mucilage exhibited better physicochemical and functional characteristics than AV mucilage as a raw material.
Affordable Magnetic Hydrogels Prepared from Biocompatible and Biodegradable Sources
Authors: Baron Raluca , Biliuta Gabriela , Socoliuc Vlad , Coseri Sergiu
Published: May 2021

Magnetic hydrogels composed of poly(vinyl alcohol) (PVA)/water-soluble tricarboxy cellulose (CO)/magnetic fluids (MFs) have been prepared by a freeze–thaw cycle technique. The system designed here combines the renewability and biocompatibility aspects of PVA and CO, as well as the magnetic properties of MFs, thereby offering special properties to the final product with potential applications in medicine. In the first step, the water-soluble CO is synthesized using a one-shot oxidation procedure and then the aqueous solutions of CO are mixed with PVA solutions and magnetic fluids in the absence of any additional cross-linking agent. The magnetic hydrogels were thoroughly investigated by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), magnetometry (VSM), and thermogravimetric analysis. The morphological results show an excellent distribution of magnetic particles and CO inside the PVA matrix. The VSM results show that the magnetic hydrogels possess superparamagnetic properties.
Injectable Thermosensitive Chitosan Solution with β-Glycerophosphate as an Optimal Submucosal Fluid Cushion for Endoscopic Submucosal Dissection
Authors: Jeong Seung , Jeon Han Jo , Jang Kyoung-Je , Park Sangbae , Choi Hyuk Soon , Chung Jong Hoon
Published: May 2021

Endoscopic submucosal dissection (ESD) is a surgical procedure to remove early neoplastic lesions in the gastrointestinal tract with the critical issue of perforation. A submucosal fluid cushion, such as normal saline, is used as a cushioning agent to prevent perforation; however, its cushioning maintenance is insufficient for surgery. In this study, we introduce an injectable thermosensitive chitosan solution (CS) with β-glycerophosphate (β-GP) as a submucosal injection agent for ESD. The CS/β-GP system with optimal β-GP concentration showed drastic viscosity change near body temperature while other commercial products did not. Additionally, the injectability of the solution was similar to or greater than other commercial products. The solution with low β-GP concentration showed low cytotoxicity similar to other products. An in vivo preclinical study illustrated maintenance of the high cushioning of the thermosensitive solutions. These results indicate that a CS/β-GP system with optimal β-GP concentration might be used as a submucosal injection agent in ESD, and further studies are needed to validate the effectiveness of the solutions in vivo.
Using Waveguides to Model the Dynamic Stiffness of Pre-Compressed Natural Rubber Vibration Isolators
Authors: Coja Michael , Kari Leif
Published: May 2021

A waveguide model for a pre-compressed cylindrical natural rubber vibration isolator is developed within a wide frequency range—20 to 2000 Hz—and for a wide pre-compression domain—from vanishing to the maximum in service, that is 20%. The problems of simultaneously modeling the pre-compression and frequency dependence are solved by applying a transformation of the pre-compressed isolator into a globally equivalent linearized, homogeneous, and isotropic form, thereby reducing the original, mathematically arduous, and complex problem into a vastly simpler assignment while using a straightforward waveguide approach to satisfy the boundary conditions by mode-matching. A fractional standard linear solid is applied as the visco-elastic natural rubber model while using a Mittag–Leffler function as the stress relaxation function. The dynamic stiffness is found to depend strongly on the frequency and pre-compression. The former is resulting in resonance phenomena such as peaks and troughs, while the latter exhibits a low-frequency magnitude stiffness increase in addition to peak and trough shifts with increased pre-compressions. Good agreement with nonlinear finite element results is obtained for the considered frequency and pre-compression range in contrast to the results of standard waveguide approaches.
Double-Cross-Linked Networks Based on Methacryloyl Mucin
Authors: Olăreț Elena , Bălănucă Brîndușa , Onaș Andra Mihaela , Ghițman Jana , Iovu Horia , Stancu Izabela-Cristina , Serafim Andrada
Published: May 2021

Mucin is a glycoprotein with proven potential in the biomaterials field, but its use is still underexploited for such applications. The present work aims to produce a synthesis of methacryloyl mucin single-network (SN) hydrogels and their double-cross-linked-network (DCN) counterparts. Following the synthesis of the mucin methacryloyl derivative, various SN hydrogels are prepared through the photopolymerization of methacrylate bonds, using reaction media with different pH values. The SN hydrogels are converted into DCN systems via supplementary cross-linking in tannic acid aqueous solution. The chemical modification of mucin is described, and the obtained product is characterized; the structural modification of mucin is assessed through FTIR spectroscopy, and the circular dichroism and the isoelectric point of methacryloyl mucin is evaluated. The affinity for aqueous media of both SN and DCN hydrogels is estimated, and the mechanical properties of the systems are assessed, both at macroscale through uniaxial compression and rheology tests and also at microscale through nanoindentation tests.
Automated Test Assembly in R: The eatATA Package
Authors: Becker Benjamin , Debeer Dries , Sachse Karoline A. , Weirich Sebastian
Published: May 2021

Combining items from an item pool into test forms (test assembly) is a frequent task in psychological and educational testing. Although efficient methods for automated test assembly exist, these are often unknown or unavailable to practitioners. In this paper we present the R package eatATA, which allows using several mixed-integer programming solvers for automated test assembly in R. We describe the general functionality and the common work flow of eatATA using a minimal example. We also provide four more elaborate use cases of automated test assembly: (a) The assembly of multiple test forms for a pilot study; (b) the assembly of blocks of items for a multiple matrix booklet design in the context of a large-scale assessment; (c) the assembly of two linear test forms for individual diagnostic purposes; (d) the assembly of multi-stage testing modules for individual diagnostic purposes. All use cases are accompanied with example item pools and commented R code.
A Systematic Review of Construction and Demolition Waste Management in Australia: Current Practices and Challenges
Authors: Kabirifar Kamyar , Mojtahedi Mohammad , Wang Cynthia Changxin
Published: May 2021

Construction and demolition waste (C&DW) has a deleterious impacts on sustainability not only in developing countries but also in developed nations. For example, Australia generated more than 27 million tonnes of C&DW in 2018–2019; however, only 60% of this waste stream was recovered. Considering this low recovery rate, lower than many developed nations, and with regards to the increasing rate of C&DW generation, extra attention should be given to the construction and demolition waste management (C&DWM) in Australia. Therefore, this research attempts to accurately understand the current practices and challenges of C&DWM in Australia. To do so, primarily, a systematic review of studies relevant to C&DWM from 2010 to 2021 was performed. In this step, 26 research documents were meticulously analysed to identify the current practices of C&DWM in Australia. Then, an in-depth interview with three experts were undertaken to verify the major results and to investigate the challenges of C&DWM in Australia. The results indicated that three factors significantly affect C&DWM in Australia, namely attitudes and behaviour of C&DWM stakeholders, C&DWM in project life cycles, and C&DWM regulations with regards to sustainability, adding that the latter was revealed as the most effective in C&DWM in Australia.
Remnant and the New Dark Age
Authors: Rommen Edward
Published: May 2021

A new dark age has come upon us; as a result, Christianity and its churches in North America are no longer growing. One reason for this might be the widespread impression that Christians are hypocrites, saying they believe one thing while doing the opposite. However, that accusation would only be true if these believers actually believed the principles they are supposed to be violating. It is more likely that many Christians have, like those around them, abandoned truth in favor of personal opinion bringing moral discourse to a near standstill and intensifying the darkness by extinguishing the light of truth. Still, there is hope. In the past, it often was a faithful few, a remnant, who preserved the knowledge of that light and facilitated a new dawn. History shows us that the very movements that are today abdicating responsibility were once spiritual survivors themselves. They withdrew, coalesced around the remaining spark of truth in order to remember, preserve, and reignite. The thoughts and practices of these pioneers could guide the escape from today’s darkness.
Yedidyah Ha-Alexandri and the Crisis of the Modern Jewish Age: Philo of Alexandria as an Exemplary Ḥasid in Naḥman Krochmal’s Thought
Authors: Strauss Ze’ev
Published: May 2021

The present article sets out to answer the question of the extent to which Naḥman Krochmal’s reappraisal of Philo of Alexandria in the light of his Jewish faith reflects a deep spiritual crisis that was engulfing the Maskilic world: the encroaching expansion of modern Hasidism with its transformed understanding of traditional Judaism among Eastern European communities. To this end, a major component of Krochmal’s Jewish historical thought as expressed in his masterful unfinished work Guide of the Perplexed of the Modern Age can be revealed. The examination employs two methods in order to uncover the intent behind Krochmal’s fragmentary presentation of Philo: exploring his utilization of Dähne’s Geschichtliche Darstellung der jüdisch-alexandrinischen Religionsphilosophie to demonstrate the congruence of Philo’s thought with Tannaitic ethics and drawing on similar depictions of Philo found among his circles and pupils. The study claims that Krochmal’s revival of Philo as a key Jewish thinker is politically mobilized for an ideological assault on the Hasidim, with whom the Maskilim had ongoing conflicts. Reconstructing his portrayal of Philo as a paragon of Second Temple Judaism, the paper argues that Krochmal projects his own spiritual crisis from the Maskilic settings of nineteenth-century Galicia onto the Jewish reality of first-century Alexandria, thus reproducing a valiant image of Philo as the embodiment of the Maskilic consciousness that was grappling with the ancient, overly theoretical Hasideans of his days.
Coping with Pastoral Burnout Using Christian Contemplative Practices
Authors: Frederick Thomas V. , Thai Yvonne , Dunbar Scott
Published: May 2021

Three Christian Devotion Meditation (CDM) practices—lectio divina, centering prayer, and the examen—will be offered to aid in coping with ministerial stress and to prevent burnout. CDM or Christian contemplative practices are uniquely suited to develop the emotional resources pastors need for coping with burnout. The office of the pastor faces pressures which can cause burnout and threaten their ministries and personal relationships. The experience of pastoral burnout consists of acedia. Pastors experience spiritual emptiness due to two unique aspects of pastoral life. First, because pastors often work alongside with their families in the church while simultaneously serving their congregants, they experience inter-role conflict due to the high level of boundary ambiguity between their vocational and family lives. Second, pastors need to rely on their psychological resources to provide for their church members due to the emotional labor required of their positions. Consequently, pastors must rely on emotional labor strategies to respond positively to their congregations, which in turn can lead to emotional exhaustion.
Municipal Urban Waste Management—Challenges for Polish Cities in an Era of Circular Resource Management
Authors: Mesjasz-Lech Agata
Published: May 2021

Municipal authorities increasingly view environmental protection as one of the goals of city management. The pro-environmental orientation of cities can, therefore, foster the creation of new management methods and instruments and promote reorganization of determining material flows in a municipal system. Activities of this kind should result not only in the reduction of generated waste but also in the creation of closed material cycles. Considering the tasks of Polish local governments, municipalities should pay the most attention to municipal waste. Accordingly, the goal of this study was to identify the problem of mixed municipal waste in cities and assess the influence of investments into fixed assets for environmental protection in the scope of waste management on the quantity of mixed municipal waste in cities. This article also identifies activities for circular resource management that need to be realized by Polish municipalities. The analysis was performed using the panel model, dynamic indexes, and critical analysis of city documents. The conducted research revealed positive trends in cities with respect to the amount of waste collected non-selectively that is conducive to circular resource management. The fact that municipal waste quantity is on the increase should encourage urban authorities to promote pro-environmental waste management behaviors among city dwellers.
Evaluation of Current Trends of Climatic Actions in Europe Based on Observations and Regional Reanalysis
Authors: Croce Pietro , Formichi Paolo , Landi Filippo
Published: May 2021

Since extreme values of climatic actions are commonly derived assuming the climate being stationary over time, engineering structures and infrastructures are designed considering design actions derived under this assumption. Owing to the increased relevance of the expected climate change effects and the correlated variations of climate actions extremes, ad hoc strategies for future adaption of design loads are needed. Moreover, as current European maps for climatic actions are generally based on observations collected more than 20 years ago, they should be updated. By a suitable elaboration of the projections of future climate changes, the evolution over time of climatic actions can be assessed; this basic and crucial information allows us to facilitate future adaptations of climatic load maps, thus improving the climate resilience of structures and infrastructures. In this paper, current trends of climatic actions in Europe, daily maximum and minimum temperatures, daily precipitation, and ground snow loads, are investigated based on available gridded datasets of observations (E-OBS) and regional reanalysis (Uncertainties in Ensembles of Regional Re-Analyses, UERRA), to assess their suitability to be used in the elaboration of maps for climatic actions. The results indicate that the E-OBS gridded datasets reproduce trends in extreme temperatures and precipitation well in the investigated regions, while reanalysis data, which include snow water equivalent, show biases in the assessment of ground snow load modifications over the years in comparison with measurements. As far as climate change effects are concerned, trends of variation of climatic actions are estimated considering subsequent time windows, 40 years in duration, covering the period 1950–2020. Results, in terms of factors of change, are critically discussed, also in comparison with the elaborations of reliable datasets of real observations, considering a case study covering Germany and Switzerland.
Plot-Based Classification of Macronutrient Levels in Oil Palm Trees with Landsat-8 Images and Machine Learning
Authors: Kok Zhi Hong , Shariff Abdul Rashid Bin Mohamed , Khairunniza-Bejo Siti , Kim Hyeon-Tae , Ahamed Tofael , Cheah See Siang , Wahid Siti Aishah Abd
Published: May 2021

Oil palm crops are essential for ensuring sustainable edible oil production, in which production is highly dependent on fertilizer applications. Using Landsat-8 imageries, the feasibility of macronutrient level classification with Machine Learning (ML) was studied. Variable rates of compost and inorganic fertilizer were applied to experimental plots and the following nutrients were studied: nitrogen (N), phosphorus (P), potassium (K), magnesium (Mg) and calcium (Ca). By applying image filters, separability metrics, vegetation indices (VI) and feature selection, spectral features for each plot were acquired and used with ML models to classify macronutrient levels of palm stands from chemical foliar analysis of their 17th frond. The models were calibrated and validated with 30 repetitions, with the best mean overall accuracy reported for N and K at 79.7 ± 4.3% and 76.6 ± 4.1% respectively, while accuracies for P, Mg and Ca could not be accurately classified due to the limitations of the dataset used. The study highlighted the effectiveness of separability metrics in quantifying class separability, the importance of indices for N and K level classification, and the effects of filter and feature selection on model performance, as well as concluding RF or SVM models for excessive N and K level detection. Future improvements should focus on further model validation and the use of higher-resolution imaging.
Response of Landscape Evolution to Human Disturbances in the Coastal Wetlands in Northern Jiangsu Province, China
Authors: Cui Linlin , Li Guosheng , Chen Yanhui , Li Lijuan
Published: May 2021

Human disturbance is one of the essential driving forces of landscape evolution. The quantitative evaluation of the spatial and temporal characteristics of landscape evolution and its relationship with human disturbance are of great significance to regional ecological protection and management and are crucial for achieving coordinated socioeconomic development and ecological–environmental protection. In this study, we took the coastal wetlands in northern Jiangsu province, China, as the research area, and proposed a quantitative evaluation method for directional landscape evolution. On this basis, the spatiotemporal characteristics of the landscape evolution from 1980 to 2020 and the relationship with human disturbance were quantitatively evaluated by combining a human disturbance index and statistical methods. The results showed that: (1) The area of the natural wetlands decreased significantly over the past 40 years, while the areas of artificial wetlands and non-wetlands increased significantly. (2) The landscape evolution process was dominated by the degradation process. The main types of degradation were natural wetland conversion to artificial wetland and non-wetland areas and Spartina alterniflora invasion. The restoration type was mainly restoration among artificial and natural wetlands. (3) The degradation of wetland landscapes demonstrated a southward shift trend and the spatial consistency with the change of the human disturbance index was high (the correlation coefficient was 0.89). (4) The human disturbance index was significantly and positively correlated with the rate of degradation, with a correlation coefficient of 0.43, and was not significantly and positively correlated with the restoration rate, with a correlation coefficient of 0.14. The findings in this paper provide additional information and theoretical guidance for the control of coastal wetland development and utilization, as well as for achieving coordinated wetland resource development together with utilization and ecological protection in the coastal wetlands of Jiangsu province, China.
Computation Approach for Quantitative Dielectric Constant from Time Sequential Data Observed by CYGNSS Satellites
Authors: Lee Junchan , Bisnath Sunil , Lee Regina S.K. , Kilane Narin Gavili
Published: May 2021

This paper describes a computation method for obtaining dielectric constant using Global Navigation Satellite System reflectometry (GNSS-R) products. Dielectric constant is a crucial component in the soil moisture retrieval process using reflected GNSS signals. The reflectivity for circular polarized signals is combined with the dielectric constant equation that is used for radiometer observations. Data from the Cyclone Global Navigation Satellite System (CYGNSS) mission, an eight-nanosatellite constellation for GNSS-R, are used for computing dielectric constant. Data from the Soil Moisture Active Passive (SMAP) mission are used to measure the soil moisture through its radiometer, and they are considered as a reference to confirm the accuracy of the new dielectric constant calculation method. The analyzed locations have been chosen that correspond to sites used for the calibration and validation of the SMAP soil moisture product using in-situ measurement data. The retrieved results, especially in the case of a specular point around Yanco, Australia, show that the estimated results track closely to the soil moisture results, and the Root Mean Square Error (RMSE) in the estimated dielectric constant is approximately 5.73. Similar results can be obtained when the specular point is located near the Texas Soil Moisture Network (TxSON), USA. These results indicate that the analysis procedure is well-defined, and it lays the foundation for obtaining quantitative soil moisture content using the GNSS reflectometry results. Future work will include applying the computation product to determine the characteristics that will allow for the separation of coherent and incoherent signals in delay Doppler maps, as well as to develop local soil moisture models.