bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytotoxic properties of unfractionated and fractionated bromelain alone or in combination with chemotherapeutic agents in colorectal cancer cells
Authors: Tsai Kuei-Yen , Wei Po-Li , Azarkan Mohamed , M’Rabet Nasiha , Makondi Precious Takondwa , Chen Hsin-An , Huang Chien-Yu , Chang Yu-Jia
Published: June 2023

Background

Colorectal cancer (CRC) is one of the most lethal cancers worldwide. Long-term survival is not achieved in metastatic CRC despite the current multidisciplinary therapies. Bromelain, a compound extracted from the pineapple plant, has multiple functions and anticancer properties. Previously, bromelain has been chromatographically separated into four fractions. Fraction 3 (F3) exhibits the highest proteolytic activity. The anticancer effects of F3 bromelain in CRC cells is unknown.

Methods

In vitro cytotoxicity was verified through a sulforhodamine B assay. Apoptosis in CRC cells induced by unfractionated or F3 bromelain was examined using Annexin V-FITC/PI staining and Western blot analysis. ROS status, autophagy and lysosome formation were determined by specific detection kit.

Results

The cytotoxicity of F3 bromelain in CRC cells was found to be comparable to that of unfractionated bromelain. F3 bromelain induces caspase-dependent apoptosis in CRC cells. Treatment with unfractionated or F3 bromelain increased superoxide and oxidative stress levels and autophagy and lysosome formation. ATG5/12 and beclin-1 were upregulated, and the conversion of LC3B-I to LC3B-II was increased significantly by treatment with F3 bromelain. Treated CQ, autophagy inhibitor, with unfractionated or F3 bromelain enhances the cytotoxic effects. Finally, the combination of unfractionated and F3 bromelain with a routine chemotherapeutic agent (5-fluourouracil, irinotecan, or oxaliplatin) resulted in synergistically higher cytotoxic potency in CRC cells.

Conclusion

Unfractionated and F3 bromelain inhibits CRC cell proliferation in vitro, and the cytotoxic effects of unfractionated bromelain are equivalent to F3 bromelain. F3 bromelain may be a potential and potent drug for clinical use due to its anticancer efficacy and high synergistic cytotoxicity when combined with a routine chemotherapeutic agent for CRC.
The impact of a rosemary containing drink on event-related potential neural markers of sustained attention
Authors: Riby Leigh Martin , Edwards Sheridan , McDonald Heather , Moss Mark
Published: June 2023

Background

Research suggests that the ingestion or aroma of rosemary enhances cognitive ability in both rodents and humans. However, how rosemary facilitates cognition and the precise therapeutic impacts on information processing remains unclear.

Hypothesis/purpose

This pilot study used the temporal precision of event-related potentials (ERPs) to examine the cognitive-enhancing benefits of a rosemary drink. Neural markers of sustained attention were used as indices to explore whether rosemary facilitates concentration in general or the allocation of resources to task-relevant information only.

Study design and methods

In a between-subject design (rosemary vs water control drink), 48 adults performed a 3-stimulus visual oddball task. Participants differentiated between rare target stimuli (index of task-relevant attentional processes; P3b ERP) embedded in a train of frequent stimuli. The presentation of an infrequent novel stimulus was also included (index of task-irrelevant stimulus processing; P3a ERP). Throughout the session, electroencephalograms (EEG) were collected and time-locked to the presentation of the target (P3b) and novel (P3a) stimulus types.

Results

The primary analyses revealed facilitation of the P3a in particular with a medium Cohen’s effect size reported. The investigation of the P3b component, although less reliable, also had a medium effect. The subsidiary consideration of the association between behaviour and the ERPs provided a further level of explanation regarding the therapeutic effect of rosemary on cognition. Indeed, the pattern of associations was suggestive of strategy differences during the performance of the task across the treatment group., although these data should be treated with caution.

Conclusions

These pilot data provide critical insights into the utility of rosemary to facilitate different aspects of attention. In particular, data are consistent with rosemary providing additional attentional resources to enhance the processing of stimuli we encounter, irrespective of task relevance. Indeed, the enhancement of both P3a and P3b components following rosemary administration may indicate that the herb enhances the processing of all stimuli in the environment. We argue for the use of both behavioural and EEG methods to explore the therapeutic effects of herbal compounds.
Prelnc2: A prediction tool for lncRNAs with enhanced multi-level features of RNAs
Authors: Gao Hua , Gao Peng , Ye Ning
Published: June 2023

Long non-coding RNAs (lncRNAs) have been widely studied for their important biological significance. In general, we need to distinguish them from protein coding RNAs (pcRNAs) with similar functions. Based on various strategies, algorithms and tools have been designed and developed to train and validate such classification capabilities. However, many of them lack certain scalability, versatility, and rely heavily on genome annotation. In this paper, we design a convenient and biologically meaningful classification tool "Prelnc2" using multi-scale position and frequency information of wavelet transform spectrum and generalizes the frequency statistics method. Finally, we used the extracted features and auxiliary features together to train the model and verify it with test data. PreLnc2 achieved 93.2% accuracy for animal and plant transcripts, outperforming PreLnc by 2.1% improvement and our method provides an effective alternative to the prediction of lncRNAs.
The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs
Authors: Tsianou Chrysostomi Christina , Kvetina Jaroslav , Radochova Vera , Kohoutova Darina , Rejchrt Stanislav , Valis Martin , Zdarova Karasova Jana , Tacheci Ilja , Knoblochova Veronika , Soukup Ondrej , Bures Jan
Published: June 2023

Background

Rivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer’s disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clinical use. The aim of this study was to assess the impact of rivastigmine on gastric motor function by means of electrogastrography (EGG) in experimental pigs.

Methods

Six experimental adult female pigs (Sus scrofa f. domestica, hybrids of Czech White and Landrace breeds; 3-month-old; mean weight 30.7 ± 1.2 kg) were enrolled into the study twice and created two experimental groups. In group A, a single intragastric dose of 6 mg rivastigmine hydrogen tartate was administered in the morning to fasting pigs before EGG recording. In group B, rivastigmine was administered to overnight fasting animals in a dietary bolus in the morning for 7 days (6 mg per day). On day 8, an intragastric dose of 12 mg rivastigmine was given in the morning to fasting pigs before EGG. EGG recording was accomplished by means of an EGG standalone system. Recordings from both groups were evaluated in dominant frequency and EGG power (areas of amplitudes).

Results

In total, 1,980 one-minute EGG intervals were evaluated. In group A, basal EGG power (median 1290.5; interquartile range 736.5–2330 μV2) was significantly higher in comparison with the power of intervals T6 (882; 577–1375; p = 0.001) and T10 (992.5; 385–2859; p = 0.032). In group B, the dominant frequency increased significantly from basal values (1.97 ± 1.57 cycles per minute) to intervals T9 (3.26 ± 2.16; p < 0.001) and T10 (2.14 ± 1.16; p = 0.012), respectively. In group B, basal EGG power (median 1030.5; interquartile range 549–5093) was significantly higher in comparison with the power of intervals T7 (692.5; 434–1476; p = 0.002) and T8 (799; 435–1463 μV2; p = 0.004).

Conclusions

Both single as well as repeated intragastric administration of rivastigmine hydrogen tartrate caused a significant decrease of EGG power (areas of amplitudes) in experimental pigs. EGG power may serve as an indirect indicator of gastric motor competence. These findings might provide a possible explanation of rivastigmine-associated dyspepsia in humans.
Development of diagnostic and point of care assays for a gammaherpesvirus infecting koalas
Authors: Wright Belinda R. , Jelocnik Martina , Casteriano Andrea , Muir Yasmine S. S. , Legione Alistair R. , Vaz Paola K. , Devlin Joanne M. , Higgins Damien P.
Published: June 2023

The recent listing of koala populations as endangered across much of their range has highlighted the need for better management interventions. Disease is a key threat to koala populations but currently there is no information across the threatened populations on the distribution or impact of a gammaherpesvirus, phascolarctid gammaherpesvirus 1 (PhaHV-1). PhaHV-1 is known to infect koalas in southern populations which are, at present, not threatened. Current testing for PhaHV-1 involves lengthy laboratory techniques that do not permit quantification of viral load. In order to better understand distribution, prevalence and impacts of PhaHV-1 infections across koala populations, diagnostic and rapid point of care tests are required. We have developed two novel assays, a qPCR assay and an isothermal assay, that will enable researchers, clinicians and wildlife managers to reliably and rapidly test for PhaHV-1 in koalas. The ability to rapidly diagnose and quantify viral load will aid quarantine practices, inform translocation management and guide research into the clinical significance and impacts of PhaHV-1 infection in koalas.
Factors affecting unmet healthcare needs in female baby boomers: Andersen model application in Korea
Authors: Park Min-Jeong , Chung Mi-Young
Published: June 2023

This study aimed to measure unmet healthcare needs and investigate the factors affecting them in female baby boomers (individuals born between 1955 and 1963) using the Korea Health Panel Data 2017 from February to June 2017 by the Korea Institute for Health and Social Affairs and the National Health Insurance Corporation. The data were analyzed using descriptive statistics, chi-square test, t-test, and multiple logistic regression using SPSS WIN 25.0 program. The results showed that the proportion of unmet healthcare needs was 11.1%, and the primary reason for unmet healthcare needs was the lack of visitation time. Female baby boomers experienced more unmet healthcare needs when they had no spouse (1.63 times), eating problems (2.33 times), and stress (1.31 times). This study is significant because it measured the unmet healthcare needs of women in the baby boomer generation and identified the factors influencing unmet healthcare needs. The study’s results can help provide essential data to decrease the unmet healthcare needs of female baby boomers.
Regulation of EBNA1 protein stability and DNA replication activity by PLOD1 lysine hydroxylase
Authors: Dheekollu Jayaraju , Wiedmer Andreas , Soldan Samantha S. , Castro- Muñoz Leonardo Josué , Chen Christopher , Tang Hsin-Yao , Speicher David W. , Lieberman Paul M.
Published: June 2023

Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that is causally associated with various malignancies and autoimmune disease. Epstein-Barr Nuclear Antigen 1 (EBNA1) is the viral-encoded DNA binding protein required for viral episome maintenance and DNA replication during latent infection in proliferating cells. EBNA1 is known to be a highly stable protein, but the mechanisms regulating protein stability and how this may be linked to EBNA1 function is not fully understood. Proteomic analysis of EBNA1 revealed interaction with Procollagen Lysine-2 Oxoglutarate 5 Dioxygenase (PLOD) family of proteins. Depletion of PLOD1 by shRNA or inhibition with small molecule inhibitors 2,-2’ dipyridyl resulted in the loss of EBNA1 protein levels, along with a selective growth inhibition of EBV-positive lymphoid cells. PLOD1 depletion also caused a loss of EBV episomes from latently infected cells and inhibited oriP-dependent DNA replication. Mass spectrometry identified EBNA1 peptides with lysine hydroxylation at K460 or K461. Mutation of K460, but not K461 abrogates EBNA1-driven DNA replication of oriP, but did not significantly affect EBNA1 DNA binding. Mutations in both K460 and K461 perturbed interactions with PLOD1, as well as decreased EBNA1 protein stability. These findings suggest that PLOD1 is a novel interaction partner of EBNA1 that regulates EBNA1 protein stability and function in viral plasmid replication, episome maintenance and host cell survival.
Out Here: Anthology of Takatāpui and LGBTQIA+ Writers from Aotearoa, Chris Tse and Emma Barnes (eds) (2021)
Authors: Rodríguez-Salas Gerardo
Published: June 2023

Review of: Out Here: Anthology of Takatāpui and LGBTQIA+ Writers from Aotearoa, Chris Tse and Emma Barnes (eds) (2021)

Auckland: Auckland University Press, 368 pp.,

ISBN 978 1 86940 931 9 (hbk), US$49.99
Tanna Times: Islanders in the World, Lamont Lindstrom (2021)
Authors: Rosier Morgane
Published: June 2023

Review of: Tanna Times: Islanders in the World, Lamont Lindstrom (2021)

Honolulu, HI: University of Hawai‘i Press, 200 pp.,

ISBN 978 0 82488 667 7 (pbk), US$28
Johnson, Dean Parker (2017)
Authors: Burns Paul
Published: June 2023

Review of: Johnson, Dean Parker (2017)

Wellington: Steele Roberts Aotearoa, 339 pp.,

ISBN 978 0 94749 353 0 (pbk), NZ$34.99
Imagining Decolonisation, Bianca Elkington, Moana Jackson, Rebecca Kiddle, Ocean Ripeka Mercier, Mike Ross, Jennie Smeaton and Amanda Thomas (2020)
Authors: Myllyntausta Mikko
Published: June 2023

Review of: Imagining Decolonisation, Bianca Elkington, Moana Jackson, Rebecca Kiddle, Ocean Ripeka Mercier, Mike Ross, Jennie Smeaton and Amanda Thomas (2020)

Wellington: Bridget Williams Books, 184 pp.,

ISBN 978 1 98854 578 3 (pbk), NZ$17.99
COVID-19 funerals: Minorities and the digital space
Authors: Enari Dion
Published: June 2023

The COVID-19 worldwide pandemic brought the world to a standstill. In particular, it changed the funeral processes of communal groups. Their collective ways of mourning were disrupted, as travel bans and social distance restrictions meant people were not allowed to physically gather. Despite these restrictions, these communities were able to maintain social connection from a distance. The communities which are being addressed in this report have been able to use the digital space to collectively engage with family and friends during the grieving process. This cohort has used the digital space to ensure funerals are still communal in nature and that family and friends remain able to gather to comfort and uplift each other. As a member of my community I present the funeral narratives, communal resilience and creativity through the digital space.
Indigenous Textual Cultures: Reading and Writing in the Age of Global Empire, Tony Ballantyne, Lachy Paterson and Angela Wanhalla (eds) (2020)
Authors: Birk Hanne
Published: June 2023

Review of: Indigenous Textual Cultures: Reading and Writing in the Age of Global Empire, Tony Ballantyne, Lachy Paterson and Angela Wanhalla (eds) (2020)

Durham and London: Duke University Press, 357 pp.,

ISBN 978 1 47801 081 4 (pbk), $29.95
Common traditional medicinal seaweeds used by Indigenous Fijians in Viti Levu, Fiji Islands
Authors: Singh Danian , Railoa Kelera
Published: June 2023

Indigenous Fijians have a long history of using medicinal resources from both land and ocean. Terrestrial medicinal plants have been documented in numerous studies carried out across the islands of Fiji but there is a dearth of research regarding marine resources. Ten marine medicinal seaweeds were documented in this study derived from information provided by villagers. Usage of these seaweeds varied depending on the type of illness and availability of resources. Common preparation methods of extracting medicinal properties from these resources include boiling the plant, raw consumption or simply using it as an ingredient in meals. Traditional healers are a crucial component of a traditional Fijian community as villagers depend on them for guidance to cure illnesses. The information collected for this study reveals an erosion of traditional knowledge occurring in Indigenous societies and highlights the need for documentation of this wealth of knowledge as well as an awareness of the importance of medicinal plants in Pacific Islands.
Lessons From A Witness Tree
Authors: Makkar Amalia
Published: June 2023

This article uses reflections from childhood memories of sensory experiences and interactions with the multispecies community to explore how the more-than-human world bears witness to one’s presence. They are also used to discuss how a greater sensory awareness of the more-than-human world increases one’s sensitivity to shared but unequal vulnerabilities in a changing and precarious climate. The author suggests that how we interact and come to know a place through the senses matters in the traces we leave and the kinds of relationships that form as a result.
Healthcare costs vis-à-vis economic growth in pandemic crisis with technology adoption
Authors: Mandal Purnendu
Published: June 2023

COVID-19 pandemic brought up issues with healthcare costs, national economic development and welfare of the society in forefront. Nations across the globe followed different approaches to deal with COVID-19, such as zero tolerance, herd immunity, containment to build treatment capability. National healthcare became a contentious sociopolitical issue involving healthcare costs, technologies and societal health. In the United States even during the COVID-19 pandemic, the government approach was pursuing a sustainable improvement in patient care through adoption of medical and information technologies. The national healthcare policies are framed around technological interventions with the assumption that deployment of technologies could keep healthcare costs under control and at the same time improve health outcomes. However, evidences show that the healthcare costs are in the rise even with impressive progress in technological deployment. This article highlights some of the recent trends in healthcare costs, technological preparedness, medical technology developments in managing COVID-19 pandemic. The US government mandated electronic health record (EHR) systems implementation and assess its impact on healthcare costs and health outcomes. This article emphasizes the need for understanding the interconnectedness of costs, technology and societal health.
Nudging the public: Relevance, antecedents and the level of public support for behaviorally informed policies
Authors:   , Dudás Levente
Published: June 2023

A viselkedési közgazdaságtan térnyerése a közgazdasági kutatások fősodrában nagymértékben kiterjesztette az emberi ítélőképességről és döntéshozatalról alkotott ismereteinket. Daniel Kahneman és Richard Thaler Nobel-díjas tudósok munkáitól inspirálva kezdtem el tudományos kutatásokat végezni a közpolitikák és kifejezetten a nudge elfogadottsága terén. Az emberek jobb döntések felé terelése olyan cél, amelyet érdemes követni, és ezt etikusan és megbízhatóan megtenni pedig szép feladat. Munkámra a globális világjárvány is hatással volt, és a megoldáshoz való hozzájárulás szándéka ve-zetett a Covidhoz kötődö attitűdök és a megelőző intézkedések támogatásának kutatásához. Disszertációm alapja a közpolitikában alkalmazott nudge-ok szisztematikus szakirodalmi áttekintése. Ez az áttekintés és kategorizálás nemcsak jó összefoglalót adott az érdeklődő olvasóknak a nudge mechanizmusairól, alkalmazásáról és kritikájáról, hanem segített megtalálni a szakirodalomban felmerülő, feltárásra érdemes kutatási kérdéseket is. Primer kutatásomat kérdőíves kutatással gyűjtött empirikus adatok alapján végeztem (mindezt kísérleti elemekkel tarkítva). A viselkedéstudományi eredményeken alapuló közpolitikák támogatásával foglalkozó befolyásos tanulmányok által inspirálva feltártam hogyan befolyásolhatja az alkalmazási terület, a mechanizmus vagy az adott kontextus az intézkedések támogatottságát. Korábbi megállapítások szerint a nudgeok bevezetése csökkentheti a szigorúbb intézkedések támogatottságát, ezért különböző típusú, azonos célú intézkedések támogatottságát is kutattam. Etikai problémákra is próbáltam választ találni azzal, hogy teszteltem a közpolitika alkotók céljának és a különböző eszközeik bemutatásának hatását. Felhasználtam a válaszadók pszichológiai tulajdonságainak mérését is, illetve ezek összefüggéseit a szakpolitikai intézkedések támogatásával számos területen. Illetve, ahogy a globális helyzet eszkalálódott, több tanulmányom is kifejezetten a járványra összpontosított, és ezeket a pszichológiai vonásokat a megelőző intézkedések támogatásával, a Covid szkepticizmussal és a kockázatészleléssel kapcsoltam össze.
A Importância da Gestão de Pessoas para o Sucesso de uma Organização
Authors: Santos Natanoelha Menezes dos , Cabral Jamille Alves , Pereira Edslany Paixão , Caffé Filho Hesler Piedade
Published: June 2023

Esta investigação teve como objetivo identificar as principais características de um gestor de pessoas direcionando a atuação nessa área. Os estudiosos da área de gestão de pessoas traçam como perfil de gestor de pessoas entender a visão dos diretores de empresas sobre suas contribuições para contratação de um gestor de pessoas ao relacionar o perfil de um gestor de pessoas, de acordo com o acervo bibliográfico existente, com os argumentos dos diretores/gestores de empresas, sobre a temática abordada. A investigação foi descritiva, quantitativa, aplicação de um questionário traçados com algumas características de perfis profissionais que os gestores de pessoas consideram durante a contratação de um funcionário. Os dados da pesquisa aponta uma população constituída por 100 profissionais da área de gestão, respondendo através de um questionário. Diante das devolutiva da pesquisa ficou evidenciado que esses gestores consideram a habilidade técnica, na hora da contratação, esses profissionais devem ter além da habilidade, o conhecimento e agilidade na execução das atividades. Em controvérsias, as outras características apontadas no estudo bibliográfico. E o que eles menos exerce diante da pesquisa realizada (30%) foi à habilidade conceitual, que refere a capacidade da visão organizacional e domínio de trabalhar com ideias e conceitos, teorias e abstrações.
Nascimento e Morte: o Apagamento do Luto durante a Perinatalidade
Authors: Ignacio Ethiene Stephanie , Medeiros Ana Paula
Published: June 2023

O luto corresponde a uma temática com a qual a população e o profissionais de saúde têm dificuldade em lidar, sobretudo quando se trata da morte de crianças, por se tratar de uma problemática que envolve ainda mais sofrimento. Este trabalho busca compreender o cenário brasileiro de cuidados materno/infantil em sua interface com o luto. Através dos achados é possível afirmar que o processo de perda materna se equivale a uma ferida narcísica capaz de desnortear a referência temporal, desencadeando quadros de sofrimento psíquico. Ressalta-se a importância do acompanhamento do profissional de psicologia através de grupos de apoio, terapia clínica ou mesmo acompanhamento pelas unidades de saúde da família. Enfatiza-se a necessidade de constantes pesquisas na temática, para que sejam delimitadas estratégias de intervenção com a população enlutada, bem como para melhor preparo dos profissionais.
Caminhos da Extensão: Um Estudo Documental no Programa Institucional de Bolsas de Extensão (PIBEX) da Univasf de 2006 a 2022
Authors: Silva Edilucia Barros da , Ramos Jorge Luis Cavalcanti , Santos Marcelo Henrique Pereira dos
Published: June 2023

Resumo: Este trabalho tem como objetivo descrever a evolução das ações de Extensão da Universidade Federal do Vale do São Francisco (Univasf), por meio do Programa Institucional de Bolsas de Extensão (PIBEX), no período de 2006 a 2022. Trata-se de fazer uma análise da trajetória do programa para construir novas perspectivas sobre a Extensão Universitária na Univasf. Para o desenvolvimento deste estudo, realizou-se uma pesquisa documental, de caráter descritivo, nos arquivos digitais da Pró-Reitoria de Extensão da Univasf. Observou-se ao longo de 16 editais do PIBEX, oscilação entre crescimento e declínio no número de submissões de projetos e de aprovações com bolsa, mas houve tendência geral de crescimento. Notou-se também a predominância de projetos aprovados nas áreas temáticas de Saúde e Educação, revelando a tendência dos docentes em colaborar com as políticas públicas dessas áreas. No entanto, é preciso ampliar o número de bolsas para despertar maior interesse de participação nos editais e beneficiar mais projetos.
Inteligência Emocional e sua Relação com o Conceito de Liderança Transformacional: Um Estudo Psicossociológico
Authors: Lima Erika Marques de Almeida , Coutinho Maria da Penha de Lima , Fonseca Aline Arruda da
Published: June 2023

Este estudo teve como objetivo associar os construtos da inteligência emocional com liderança transformacional a partir do aporte teórico das Representações Sociais. Participaram 50 colaboradores, com idades de 18 a 55 anos (M=35,47), de uma Instituição de ensino superior no Estado da Paraíba. Como instrumentos, foram utilizados um questionário sociodemográfico e a Técnica de Associação Livre de Palavras. A produção textual foi processada com o auxílio do software ALCESTE e analisadas pela Classificação Hierárquica Descendente, os dados sociodemográficos por meio do SPSS (versão 21). Dos resultados, emergiram três classes temáticas, ancoradas no conceito de liderança transformacional, na concepção da inteligência emocional e em contribuições do líder para a equipe. Através das falas dos interlocutores estes apresentaram um perfil de líder participativo, na intervenção de apoio aos seus liderados, o foco é poder, a partir dos resultados, expandir os conceitos estudados para melhor desenvolvimento pessoal e profissional de cada envolvido.
Resíduos de Serviços de Saúde e seus impactos em Almenara – MG
Authors: Oliveira Lucas Ribeiro de , Sousa Ramon Oliveira de , Nascimento Ednardo de Souza , Coelho Viviane Amaral Toledo , Coelho Thomaz , Souza Carla Giselly de
Published: June 2023

Os avanços industriais e tecnológicos, promoveram inúmeros benéficos para a sociedade no presente século. Esses avanços trouxeram como consequência um desgaste do meio ambiente e o aumento dos resíduos. Desses resíduos, os RSS têm ganhado destaque pelo seu grande potencial de risco, e pela necessidade de estudos e pesquisas. Sendo assim, a pesquisa teve como objetivo caracterizar e descrever os processos de produção, armazenamento, descarte e tratamento dos resíduos de serviço de saúde, Ao final do trabalho foi realizado um estudo pratico do tipo quanti-qualitativo nas instituições voltadas para os setores de saúde na cidade de Almenara - MG. Os resíduos de serviço de saúde, apresenta um alto grau de complexidade, pois se caracteriza por ser resíduos que contém potencial infectante, podendo causar acidentes tanto a saúde humana, quanto ao meio ambiente. Com a pesquisa realizada nas instituições de saúde na cidade Almenara- MG, foram detectados uma falha nas formas de armazenamento, coleta, tratamento e descarte desses resíduos. Foram evidenciadas imprecisões no sistema de saúde das empresas públicas e privadas, o que é um fator preocupante aos Órgãos Públicos.
Apresentações Atípicas de Artrite Reumatoide: Uma Revisão Integrativa da Literatura
Authors: Silva Melina Maria Batista , Maia Larissa Peixoto , Freixedelo Bruna de Almeida , Bezerra Larissa de Carvalho , Bringel Bruna Ádria Carvalho , Ribeiro Caroline de Almeida Cabral
Published: June 2023

A artrite reumatoide é uma doença inflamatória autoimune de caráter sistêmico que afeta predominantemente as pequenas articulações, apresentando frequentes manifestações extra articulares e, por vezes, atípicas. Este trabalho tem por objetivo realizar uma revisão integrativa da literatura quanto apresentações atípicas da artrite reumatoide. Seguimos o método de revisão narrativa da literatura a partir de uma busca no banco de dados eletrônicos BVS para a identificação de artigos dos últimos 2 anos seguindo os itens de Diretrizes para Revisões Sistemáticas e Metanálises (PRISMA). Na estratégia de busca utilizamos os seguintes descritores em saúde: “artrite reumatoide” and “sintomas incomuns” OR “clínica atípica”. Esta patologia possui uma ampla ocorrência de sintomas que se acumulam ao longo da vida do paciente e possuem características inespecíficas. As manifestações atípicas da artrite reumatoide elevam a piora do prognóstico e reduzem a sobrevida do indivíduo, logo são de suma importância clínica.
Crimes Ambientais Durante o Governo Bolsonaro 2018-2022
Authors: Nascimento Rayssa Kelly de Oliveira , Reis Geórgia de Abreu Barbosa , Santos Marcelo Henrique Pereira dos , Santiago Alvany Maria dos Santos , Silva Bruno Cezar
Published: June 2023

Esse artigo busca, a partir da exposição da evolução das Políticas Públicas de Meio Ambiente e da aplicabilidade da Lei de Crimes Ambientais nº 9605/98, enfocar principalmente os atos e ações praticadas durante o governo Bolsonaro (2018-2022). Dessa forma, realizou-se um levantamento das multas registradas pelo Instituto Brasileiro do Meio Ambiente e Recursos Naturais Renováveis (IBAMA). Os dados foram obtidos com base em consultas públicas dos autos de infração no site do IBAMA sobre os crimes contra unidade de conservação, fauna, flora e qualidade ambiental nos últimos 10 anos. Além disso, foi realizado o levantamento do orçamento disponível para o Ibama dos anos de 2015 a 2021, na plataforma do Sistema Integrado de Planejamento e Orçamento - SIOP, dados esses constantes nas LOAS de 2015 a 2021. A partir das análises concluiu-se que apesar do efetivo crescimento de estrutura e conquistas na política nacional ambiental, constatou-se uma tentativa de desmonte na política de meio ambiente durante o governo Bolsonaro, pode-se também perceber que mais crimes foram cometidos, entretanto mesmo com o desmonte da estrutura desta política pública, precarização do trabalho, perseguição aos servidores públicos, os funcionários dos órgãos ambientais fizeram o possível para cumprir com seus deveres.
O Sofrimento Psíquico: Influências Identificadas acerca do Processo de Escolha Profissional em Jovens
Authors: Figueiredo Samara Leite de , Maranhão Thércia Lucena Grangeiro , Farias Athena de Albuquerque , Teixeira Paulo Tadeu Ferreira , Cruz Hellen Lúcia Macedo
Published: June 2023

A pesquisa tem como objetivo geral identificar os fenômenos determinantes que envolvem o processo da escolha profissional, considerando o sofrimento gerado pelo ato de decidir a carreira futura em jovens de um cursinho pré-vestibular. A metodologia utilizada foi um questionário com questões objetivas e subjetivas, os dados foram analisados a partir da abordagem quanti-qualitativa, utilizando representações de quadros e gráficos, enfatizando análise estatística descritiva e a análise de conteúdo de Bardin. Os resultados obtidos corresponderam na apresentação dos fatores que exercem influências na escolha profissional que ocasionam o sofrimento psíquico nos jovens, os mesmos indicaram que surgem as preocupações refletindo em inseguranças, nervosismos e ansiedades, destacando a entrada no mercado de trabalho, expectativas familiares, mídias e status profissional, as expectativas quanto ao projeto futuro refere-se ao valor pessoal, qualidade de vida e reconhecimento pessoal e profissional. Considera-se que é de grande relevância a adoção de produções científicas e intervenções voltadas ao ramo da orientação profissional, podendo amenizar o sofrimento psíquico por ocasião da escolha profissional, evitando insatisfações e evasões escolares.
Incertidumbres sociales asociadas la gestión de los riesgos de desastre por inundaciones en la Provincia de Entre Ríos (Argentina)
Authors: Visintini María Laura , Rivero Victoria Soledad
Published: June 2023

El trabajo presenta un análisis sobre la dimensión de la incertidumbre social como una de las componentes del riesgo, en particular vinculado a inundaciones urbanas con el objetivo de conocer cuáles son las herramientas jurídicas e institucionales disponibles, el grado de desarrollo, dificultades y potencialidades; así como también los aportes académicos sobre el conocimiento de los riesgos y su gestión en la provincia de Entre Ríos. Se advierte un diferente estado de avance tanto en el conocimiento y consecuentemente en la gestión de los riesgos en virtud de las diferentes peligrosidades que tienen las ciudades entrerrianas a un lado y otro de las riberas de los ríos Paraná y Uruguay.
Re-lectura de una lectura crítica de Antígona
Authors: Femenías Maria Luisa
Published: June 2023

Mi artículo se propone rescatar el valor anticipatorio del artículo de la Dra. Vidiella y de la prof. Cabrera de 1989 sobre la interpretación hegeliana de la figura de Antígona. Con un método que expone a Hegel contra sí mismo, las autoras iluminan el sesgo patriarcal de su lectura. La Ley de la sangre sobre la que se basa la familia, como ley divina, contra la ley de la pólis construida en base a la naturaleza humana, mostrando que solo toma en consideración la “naturaleza humana masculina, por lo que excluye a todas las mujeres de la pólis y de la ciudadanía. Las autoras exploran también cómo otros prejuicios, propios del siglo XIX°, también interfieren en la lectura de Hegel, tal como la ambigua relación de Antigona con su hermano Polinices y la situación trágica de Creonte.
El Juicio a la Justicia Patriarcal como experiencia feminista de resistencia epistémica
Authors: Suarez Tome Danila
Published: June 2023

El artículo ofrece un análisis, desde la epistemología feminista, del Juicio a la Justicia Patriarcal, proceso feminista y latinoamericano llevado adelante por la organización Feministas de Abya Yala. La hipótesis es que esta experiencia constituyó un foco de resistencia epistémica al conjunto de injusticias epistémicas que padecen las mujeres, lesbianas, travestis y trans de América Latina, y que actúan como barreras de acceso a la justicia.
Estrés megalopático y manía demiúrgica. Para una lectura de "La fuerte razón para estar juntos”, de Peter Sloterdijk
Authors: Fuentes Martín Sebastián
Published: June 2023

En esta reseña se analizan las tesis más importantes desarrolladas por Peter Sloterdijk en La fuerte razón para estar juntos, publicado en español en el año 2022. La clave de lectura propuesta establece vinculaciones entre esta obra y los escritos del año 1993 —puntualmente, En el mismo barco y Extrañamiento del mundo—. Estas relaciones inter-textuales tienen por objeto contextualizar la afirmación central del ensayo: las sociedades contemporáneas son comunas auto-estresantes. A través de la reconstrucción general de esta idea, se presenta aquí una aproximación sistemática al modo particular en que Sloterdijk afronta el problema filosófico de la pertenencia y la identidad a la luz del significado que los nueve de noviembre tienen para la historia alemana.
Boecio y el problema de la voluntad
Authors: Uanini Federico
Published: June 2023

En el presente trabajo proponemos mostrar la presencia de elementos estoicos en La Consolación de la Filosofía de Severino Boecio, en particular en los libros I, II, III y IV. Para ello realizaremos, en un primer momento, un análisis de la Consolatio como género filosófico en donde abordaremos la obra del autor romano y sus características peculiares. En un segundo término, centraremos nuestro análisis en mostrar los elementos terapéuticos que tienen presencia en dicha obra, centrándonos en aquellos de origen estoico que pueden encontrarse cuando se analizan los bienes aparentes, las pasiones que ellos generan y su relación con la Fortuna. En un tercer momento, expondremos cómo aquellas observaciones de estilo estoico desembocan en un análisis sobre la voluntad y dignidad humana. En cuarto lugar, culminaremos el trabajo con unas breves palabras finales sobre lo antes expuesto.
Creer o no creer, ¿es esa la cuestión?
Authors: Katz Azul Tamina
Published: June 2023

Husserl analiza progresivamente a la fantasía por oposición a la originariedad de la percepción -cuyo modelo constitutivo es la aprehensión de contenidos presentes-, a la mediatez de la conciencia de imagen -especie de representación indirecta-, y a la posicionalidad de la rememoración -para la cual se desarrolla el modelo de la modificación reproductiva-. El presente trabajo muestra cómo, a partir de este análisis por contraste con otras vivencias intencionales, la fantasía llega a ser caracterizada como un tipo inactual de modificación reproductiva, más precisamente, como la “modificación de neutralidad de la presentificación ponente” (Ideas I, § 111). Luego de objetar que esta definición asimila a la fantasía a una suerte de recuerdo indeterminado en detrimento de su especificidad productiva y libre, propone que una caracterización más adecuada debe ir más allá de la cuestión, desde luego fundamental, de si creer o no creer, y afirmar su carácter a la vez inactual y quasi-productivo.
Integral Education with Societal Extension: Factoring Social Environment to Empower Future Generations with Holistic Human Development and Social Leadership
Authors: SAHOO Manoj Kumar , DIVI Sriram
Published: June 2023

This paper explores ways to integrate social responsibility approach to human development and analyses the feasibility of imparting social-leadership among the youth through incorporating social environment and integral teaching-learning pedagogy. The research method adopted is narrative-analytical exposition. The paper finds that co-operative rights-based approach and social responsibility approach in education can collectively create an appropriate ecosystem that can fulfill suitable developmental needs of the society and help in sustenance of development attainments.
Impact of COVID-19 Pandemic on Redang and Perhentian Island Communities Behavioral Strategy
Authors: MOHAMAD Zaleha , NASIR Aslina , RASHID Noorhaslinda Kulub Abd , BACHOK Zainudin
Published: June 2023

Pandemic COVID-19 did not only affect the tourism activities and income of islands in Negeri Terengganu but their behaviours after pandemic also changed especially B40 communities in Redang and Perhentian Islands.This study is to determine the impact of COVID-19 pandemic shock on Redang and Perhentian Island communities’ behavioral strategy. The regression analysis was performed into 4 models. Model 1i and 1ii were conducted to determine the impact of COVID-19 pandemic shock on communities’ behavioral strategy in Redang and Perhentian Island, respectively. Meanwhile, model 2i and 2ii were to determine the impact of pandemic shock’s components on communities’ behavioral strategy. The findings showed that 25.2% and 39.3% behavioral strategy are explained by pandemic shock in Redang and Perhentian Island, respectively. Besides, 34.3% and 47.8% of behavioral strategy respondents in Redang and Perhentian Island are explained by economy shock, health shock, politic shock and risk management, respectively. Furthermore, the economic shock is dominant factor affecting the behavioural strategy among respondents in Redang Island to overcome problem regarding expenditure and spiritual practice, followed by risk management and health shock. Whereas economic shock is also dominant factor affecting the behavioural strategy among respondents in Perhentian Island, followed by health shock, risk management and environmental shock.
The Impact of Marine Ecotourism Development in Rupat Island Indonesia
Authors: WARNINGSIH Trisla , KUSAI Kusai , BATHARA Lamun , DEVIASARI Deviasari
Published: June 2023

The tourism sector has made considerable contributions to the realization of economic equality, especially among the community living in coastal areas who are highly dependent on marine resources. This research was conducted in July 2022 in the marine ecotourism area of Rupat Island, Riau Province to analyze the impact of developing marine ecotourism on Rupat Island. Primary and secondary data collected through surveys were analyzed using the multiplier effect analysis. The results of the analysis resulted in a Keynesian Income Multiplier value of 1.03, indicating an increase in the income of workers and business owners in the marine ecotourism area of Rupat Island. The increase was to be 1.03 rupiah and with Income Multiplier Type I ratio of 1.07 and Type II ratio of 1.09. It can be taken into conclusion that the tourism activities on Rupat Island bring effects on the local community.
Rural Farms as a Strategy for the Development of Agritourism: A Study in the City of Milagro, Ecuador
Authors: SALTOS-LAYANA Andrea , CARVACHE-FRANCO Mauricio , CASTRO-ITURRALDE Galo , CARVACHE-FRANCO Wilmer , GRANDA-MALDONADO Santiago , CARVACHE-FRANCO Orly
Published: June 2023

This article aims to evaluate the current conditions of rural farms located in Milagro-Ecuador to analyze the importance of development of agritourism in this city. The study was carried out through the application of a questionnaire to know the perspectives of the owners of tourist farms. The findings showed that most of the tourist farms in the city are managed by the family, main activity of the farms is still agriculture, however they have decided to invest in tourism as an activity of additional economic income, that indicates that farm-based tourism in farming offers some potential to generate supplemental revenues. This study provides useful information for understand this kind of business and its implications in order to facilitate the integrated and Sustainable Tourism Planning of this city.
Harnessing Mother Tongue Diversity for Education in a Globalized Society: A Literature Review
Authors: Kalu Ntite Orji
Published: June 2023

Diverse cultures and languages traverse borders, including the global educational space, hence the need to create cultural and mother tongue awareness. This paper adopts a theoretical research design, in its review of some articles to discuss the best ways mother tongue diversities can be harnessed in our schools to create a universal system of education that reduces educational inequities and leads to economic growth and cohesion. This review appraises the challenges associated with harnessing mother tongue diversities, and also discusses the benefits of harnessing mother tongue diversities for the students as a preferred solution for maintaining a culturally inclusive learning environment that allows students to flourish in the educational environment by putting their mother tongue into use.
Creating an Acmeology-Based Inclusive Environment for Students from the Temporarily Occupied Territories
Authors: Marakhovska Natalia
Published: June 2023

A result of the undeclared Russo-Ukrainian war is the new concept of ‘internally displaced persons’, the majority of whom are young people looking for learning and vocational opportunities and for this a conducive environment is needed. This article illustrates the experience of Mariupol State University (Ukraine) in organising an acmeology-based inclusive environment that aims to reach the students’ highest possible developmental potential and welfare.
Extension of the working time of dental composites due to a new type of white operating lamp
Authors: von Bülow Albrecht , Gente Ralf , Gente Michael
Published: June 2023

Objectives

Dental composite materials for filling teeth are usually hardened by polymerisation lamps emitting blue light. However, the same wavelength is also emitted by light of dental operating lamps for lighting the oral cavity. Thus, the hardening of the composite is already initiated earlier, shortening the time of formability. The objective of this study is to develop a specific white LED for dental operating lamps. When restoring teeth, it enables dentists to work longer on light-curing composites in the same brightness.

Methods

Based on a short-wave blue coloured LED and a fluorescent substance, a white luminescent LED with a colour temperature of approx. 3,000 K is produced as a prototype. The formable working times of three composites are measured for this LED and two dental head lamps at an illuminance of 10,000 lx.

Results

Shorter working times of 98–237 s were measured for the headlamps and 409–807 s for the new LED. This light of the new LED is perceived by the human eye as warm white.

Conclusions

The new LED extends the working time by the factor of 3.0 to 5.8 compared to the head lamps. This enables more precise modelling of fillings.
Learner autonomy and English achievement in Chinese EFL undergraduates: the mediating role of ambiguity tolerance and foreign language classroom anxiety
Authors: Chen Lilan
Published: June 2023

For Chinese EFL students, learning English has always been a great challenge, and research has shown that cognitive and affective factors increasingly become important issues in the field of foreign language learning and teaching (Naderifar and Esfandiari 2016). This study is designed to investigate the relationship between learner autonomy, ambiguity tolerance, foreign language classroom anxiety (FLCA) and English achievement. It also explores the inner mechanism of the relationship between learner autonomy and English achievement in Chinese EFL undergraduates. A sample of 291 third and fourth grade undergraduates in China was assessed for their levels of learner autonomy, ambiguity tolerance and foreign language anxiety using the Learner Autonomy Questionnaire (LAQ), Second Language Tolerance of Ambiguity Scale (SLTAS) and Foreign Language Classroom Anxiety Scale (FLCAS), respectively. Participants’ scores of the College English Test Band Four (CET-4) were used to measure their achievement in English. The results revealed a link between learner autonomy, ambiguity tolerance, FLCA, and English achievement. Ambiguity tolerance and FLCA mediated the relationship between learner autonomy and English achievement, accounting for 36.58 % of the total effect. These findings suggest a process through which ambiguity tolerance can decrease FLCA and identify the mediating effects of ambiguity tolerance and FLCA in the relationship between learner autonomy and English achievement in Chinese EFL undergraduates. Pedagogical implications of the study are presented and discussed.
The (im)possibility of breaking the cycle of rippling circularities affecting Australian language education programs: a Queensland example
Authors: Díaz Adriana R. , Fillmore Naomi , Cordella Marisa
Published: June 2023

The state of language education in Australia has long been described as paradoxical. Oscillating between periods of increased attention and seeming invisibility, over the last thirty years, the language learning sector has been punctuated by a succession of aspirational declarations and funding injections with little long-term impact on its overall standing. Despite the increasingly multilingual makeup of Australian society, language education at all levels has largely remained stuck amidst monolingualising education policies and alarmist discourses. The latest instance of this paradoxical condition is a fee-reduction incentive for university students to study a language, which, in practice, stands to further weaken the language offerings in many Higher Education institutions. In this paper, we use the imagery of circularities and ripples to explore the challenges facing language education across sectors in Australia. Through data collected in Queensland secondary schools, we discuss how these challenges transcend the traditional delineation of macro-, meso-, and micro-levels of language policy and planning. We argue that challenges go both in circles within the same level (circularity) and flow outwards to other levels (ripples), which include Higher Education. For this reason, siloed approaches to funding and scholarly research contribute to a wicked state of inertia and, ultimately, diminish opportunities to break free from these cycles in the future. We conclude by acknowledging our complicit roles and ethical responsibilities as Higher Education scholars in the perpetuation of these cycles, as but a first step in engaging productively with the possibilities of leveraging these rippling circularities.