bluuebunny/crossref_metadata_2025 huggingface dataset:
DEPREMİN LACAN’IN PSİKANALİZ KURAMI BAĞLAMINDA SEMİYOLOJİK BİR ANALİZİ: THE QUAKE FİLMİ
Authors: Sarıgül Abdulselami , Karabulut Ahmet , Aydin Halil
Published: December 2024

Çok boyutlu bir sanat dalı olarak sinema, popüler kültürün aktarılmasında önemli araçlardan biri olarak değerlendirilmektedir. Gelişen teknolojik imkanlar, sinemanın ulaşılabilirliğini ve etki alanını arttırmış böylece sinema filmlerinin sadece salonlarda değil aynı zamanda dijital platformlarda da yer almasını sağlamıştır. Sinemanın sahip olduğu bu etki alanı, toplumun aynası olma rolünü üstlenerek güncel olayların nabzını tutmayı böylece güncel sosyal gerçekleri içinde bulunduğu topluma aktarmayı hedeflemekte bunu yaparken de görsellerden ve sanatın sınırsız imkanlarından yararlanmaktadır. İşte tam bu noktada sinema aracılığıyla aktarılmak istenen mesajların çözümlenmesinde psikanaliz kuram ve semiyoloji gibi modern çözümleme yöntemleri devreye girmektedir. Çünkü bu kavramlar, görünenin arkasındaki mesajları algılamayı ve açıklamayı amaçlamakta ve bu amaç doğrultusunda kültürel kodları ve anlamın inşa edilmesi sürecinde nasıl oluşturulduğuna odaklanmaktadır. Sinemanın ve modern görsel çözümleme yöntemlerinin arasındaki uyum, bu çalışmanın amacının belirlenmesinde önemli bir rol oynamıştır. Çalışmada, doğal afetlerden yola çıkıp depremi konu alan The Quake filminin semiyolojik olarak incelenmesi amaçlanmış ve bu amaç doğrultusunda da Lacan’ın psikanaliz kuramı esas alınmıştır. Göstergebilimsel yöntemin kullanıldığı çalışmadan elde edilen görsel ve psikanaliz çözümlemelerde, doğal afetlerin insanların psikolojilerini olumsuz etkileyebileceği yönünde anlamlara ulaşılmıştır. Doğal afetlerin bazı durumlarda travmalara yol açabileceği ve depresyon vb. olumsuz durumları tetikleyebileceği görülmüştür. Ayrıca deprem gibi doğal afetlerin psikolojik açıdan birleştirici ve kişilerarası bağları onarıcı yönlerinin bulunduğu minvalde kanıtlara ulaşılmıştır.
ANALYSIS OF THE EFFECT OF ION IMPLANTATION ON CORROSION RESISTANCE AND CONTAMINATION OF HEAT TRANSFER SURFACES
Authors: Savelev Ilya , Marushin Leonid A , Chugaev Evgeniy A , Semochkin Ilya S
Published: December 2024

BACKGROUND: the article addresses the problem of improving the energy efficiency and durability of heat exchange equipment. Particular attention is paid to improving the characteristics of heat exchange surfaces of heat exchangers, which play a key role in many industries. The problems of pollution and corrosion of heat exchange surfaces and the causes that led to them are discussed.
AIMS: analysis of the effect of ion implantation on the contamination and corrosion resistance of heat exchange surfaces of heat exchange equipment
MATERIALS AND METHODS: Within the framework of this study, comparative analysis methods were used to record changes in the composition of the surface layer of the samples under study. Microhardness studies were carried out in the direction from the surface to the depth of the test sample using the Neophot-2 instrument on transverse metallographic sections cut perpendicular to the implantation.
RESULTS: During the study, data were obtained on changes in microhardness of aluminum samples after nitrogen implantation, as well as on changes in the structural composition of surface layers and increased resistance to corrosion, contamination, and prolonged exposure to surfactants.
CONCLUSIONS: As a result of the work, it can be said that a decrease in energy efficiency due to contamination of heat exchange surfaces is more pronounced in heat exchangers in which a high value of the heat transfer coefficient was initially laid down. Ion implantation not only increases the microhardness and wear resistance of materials, but also prevents the appearance of an oxide film, which in turn reduces the contamination of the heat exchange surface, and also makes the heat exchange surface less susceptible to prolonged exposure to surfactants
Changes in the content of luteinizing and follicle-stimulating hormones in the gonads of Danio rerio fish under the action of a synthetic analogue of kisspeptin 1
Authors: Nuzhnova Alina A. , Kostina Marina I. , Blazhenko Aleksandra A.
Published: December 2024

BACKGROUND: Kisspeptin 1 plays a significant role in regulating the activity of the hypothalamic-pituitary-gonadal axis. It is known it interacts directly with gonadotropin-releasing hormone by stimulating its secretion in the hypothalamus and thus affecting downstream sex hormones via gonadotropins, but the exact mechanism of kisspeptin 1 effects on follicle-stimulating and luteinizing hormones is poorly understood.
AIM: To investigate the effects of a synthetic kisspeptin 1 analog on follicle-stimulating and luteinizing hormone levels in the gonads of Danio rerio.
MATERIALS AND METHODS: The study involved 84 sexually mature Danio rerio females after spawning. The model animals were anesthetized with lidocaine and synthetic analog of kisspeptin 1, 0.9% sodium chloride solution were administered intracerebrally in doses of 2, 8 µg/kg. After 1 or 4 hours, follicle-stimulating and luteinizing hormone’s levels were measured using enzyme immunoassay.
RESULTS: A statistically significant increase in follicle-stimulating hormone levels occurs at a dose of 8 µg/kg after 1 and 4 hours and at a dose of 2 µg/kg 4 hours after injection relative to the corresponding control groups. An increase in luteinizing hormone’s production was also recorded at a dose of 8 μg/kg after 1 and 4 hours of exposure compared with the control. Elevated follicle-stimulating and luteinizing hormone’s levels were also recorded at a dose of 8 μg/mg and exposure for 1 hour relative to a dose of 2 μg/kg at the same resting time. Without taking into account the time exposure, the administration of synthetic analog of kisspeptin 1 at a dose of 8 µg/kg leads to an increased level of both hormones, and a dose of 2 µg/kg contributes to an increase in luteinizing hormone’s level.
CONCLUSIONS: The obtained results contribute to the study of pharmacological functions of synthetic analog of kisspeptin 1 and in the future can be used for therapeutic purposes in the treatment of diseases of the gonadal system.
Neuronal protein GAP-43 in early mouse embryos
Authors: Zakharova Faina M. , Yagovkina Nadezhda A. , Zakharov Vladislav V.
Published: December 2024

BACKGROUND: GAP-43 (growth-associated protein 43) is a specific neuronal protein of vertebrates, which is predominantly localized at the plasma membrane of axon terminals. GAP-43 plays an important role in axon growth cone guidance, neuroregeneration and synaptic plasticity. We have recently shown that GAP-43 is also present in mouse oocytes and zygotes, where the protein exhibits cytoplasmic localization, which presumably results from peculiar GAP-43 expression and modifications in these cells.
AIM: The aim of the research was to study GAP-43 localization in early (preimplantation) mouse embryos, from zygote to blastocyst stage.
MATERIALS AND METHODS: C57BL/CBA F1 hybrid mice were used in the work. Oocytes and zygotes were obtained by hormonal stimulation of female mice. For immunocytochemical staining of oocytes and early embryos, primary polyclonal antibodies to GAP-43 and Ser41-phosphorylated GAP-43 were used.
RESULTS: The intracellular distribution of GAP-43 protein in mouse oocytes (at the metaphase II stage) and early embryos — from the unicellular stage (zygote) to the blastocyst stage — was studied by immunocytochemical assay. In oocytes, there is a uniform distribution of protein throughout the cytoplasm with the highest intensity of staining in the meiotic spindle region. In early embryos, GAP-43 is present in the nuclei and cytoplasm. The relative amount of GAP-43 in the nucleus and cytoplasm varies depending on the stage of embryo development and the cell cycle phase of blastomeres. The phosphorylation of GAP-43 at Ser41 residue, which is characteristic of neurons, is also observed in the nuclei and cytoplasm of early embryo cells. At blastocyst stage, the high expression of GAP-43 is preserved only in the pluripotent cells of the inner cell mass.
CONCLUSIONS: For the first time, we have demonstrated the presence of GAP-43 protein in early mouse embryos. The significant difference between GAP-43 localization in neurons (plasma membrane) and early embryo cells (cytoplasm and nucleus) was revealed. The results suggest a specific role of GAP-43 in toti- and pluripotent cells of early embryos.
Social isolation in patients with age-related visual pathology
Authors: Popova Natalia V.
Published: December 2024

BACKGROUND: Social isolation and loneliness can affect individuals of all ages, but in many countries, they are particularly prevalent among older adults. Despite this, the social isolation of patients with sensory impairments, especially visual deficits, has not been extensively studied.
AIM: To study the social isolation in patients with age-related visual pathology.
MATERIALS AND METHODS: 136 patients aged 60–74 with non-operated cataract and 136 age-matched individuals without any form of cataract were examined. When identifying the social isolation syndrome, a modified version of the social isolation index was used, consisting of five points: marital status or living situation, interaction with children, interaction with relatives, interaction with friends, and societal participation. Relative risk indicators (OR) and 95% confidence intervals (CI) were calculated to study the association with social isolation.
RESULTS: Elderly patients with non-operated cataracts showed a significant increase in social isolation associated with the duration of the condition (OR=2.21; 95% CI 2.03–2.54; p 0.01), average per capita income of patients (OR=1.82; 95% CI 1.63–2.15; p 0.01), presence of arterial hypertension (OR=1.53; 95% CI 1.41–1.82; p 0.01), and type 2 diabetes mellitus (OR=1.47; 95% CI 1.38–1.69; p 0.01). A higher risk of social isolation in patients with non–operated cataracts is observed in severe visual impairment (OR=3.56; 95% CI 3.17–3.82; p 0.001).
CONCLUSION: Social isolation among elderly patients with non-operated cataract is associated with the duration of age-related cataract and per capita income. The strongest association with social isolation was observed in patients with severe visual impairment caused by age-related cataracts.
Characteristics and nosological structure of recurrent disability due to non-rheumatic aortic valve defects among people over working age in Moscow in 2017–2023
Authors: Zapariy Sergey P. , Smotrina Svetlana V. , Okhlopkov Vitaly А.
Published: December 2024

BACKGROUND: Valvular heart defects are prevalent globally, ranging from 5 to 10 cases per 1,000 people, with the incidence increasing with age. Aortic stenosis, primarily due to aortic valve calcification, is the most common lesion. In Russia, the aging population has led to a rise in disability rates in this group.
AIM: To study the characteristics and nosological structure of recurrent disability due to non-rheumatic aortic valve disease among people over working age in Moscow in order to develop preventive measures for morbidity and disability in this group, and to provide recommendations for improving comprehensive medical and social rehabilitation.
MATERIALS AND METHODS: The study focused on individuals over working age with non-rheumatic aortic valve disease who were re-evaluated by the bureau of the branch of the Federal Governmental Institution “Main Bureau of Medical and Social Expert Evaluation in Moscow” of the Ministry of Labor of the Russian Federation. The study covered a 7-year period from 2017 to 2023. Descriptive statistics and statistical analysis were employed.
RESULTS: Recurrent disability due to non-rheumatic aortic valve disease among people over working age in Moscow in 2017–2023 showed a rise in the number of individuals re-recognized as disabled (593 cases, average growth rate of 45.7%, average level of 0.24±0.05 per 10 000 of the corresponding population). There was a predominance of male disabled individuals (311 cases), though their share tended to decrease (52.4%, average growth rate of +15.1%) and their incidence declined to 0.12 per 10 000. Conversely, the proportion of women with disabilities increased (47.6%, average growth rate +16.2%) along with their incidence level (0.11 per 10 000). According to the severity, Group III disability prevails (517 cases), with a growing share (87.5%) and incidence level (0.21 per 10 000), while Group II disability cases declined (12.5%) with an incidence of 0.03 per 10 000. Aortic stenosis accounted for a significant portion of disabilities (298 cases), representing 50.3% of all aortic valve damage issues.
CONCLUSION: The results of the study indicate the need for screening programs to identify this pathology among the working age population using modern diagnostic methods. When developing comprehensive medical and social rehabilitation measures, it is necessary to take into account age-related physiological changes to maintain preserve functional activity and improve the quality of life of people older than working age after surgical correction of aortic valve defects.
Integration of History and Sociology: Marc Bloch’s La Société féodale and Norbert Elias’ Die höfische Gesellschaft
Authors:   The Korean Society For German History, 최 성철
Published: December 2024

본 논문은 마르크 블로크의 『봉건사회』를 역사사회학의 연구 성과물로, 노르베르트 엘리아스의 『궁정사회』를 사회사의 저작으로 읽어냄으로써, 역사학과 사회학의 통합의 길을 모색해 보고자 시도했다. 연구목적, 연구대상, 접근방식, 연구방법, 서술형식, 핵심용어, 강조점 등을 분석한 결과, 두 작품은 모두 특정 시대의 사회구조, 사회조직 등이 어떻게 형성되어 변화했고, 해당 사회의 각 계급의 사람들이 내외부적으로 어떤 원리와 방식으로 결합해 갔는지를 추적해 나갔다. 이 과정에서 두 작품은 모두 ‘역사’와 ‘사회’라는 핵심 개념 그리고 역사학적이고 사회학적인 방법을 활용하고 있었다. 결론적으로 블로크의 『봉건사회』는 역사사회학으로, 엘리아스의 『궁정사회』는 사회사로 각각 이해해도 거의 무방한 것으로 밝혀졌다. 이를 통해 다음과 같은 중요한 사실이 대두된다. 즉 역사학은 연구의 지평을 넓히고 깊이를 심화시키기 위해 사회학만이 아니라 더 나아가 다른 인접 인문과학 또는 다른 사회과학, 심지어 자연과학과의 협업이나 통합 가능성까지 모색해 나갈 필요가 있다.
İşyeri Nezaketsizliğinin Çalışan Sessizliğine Etkisinde Ruminasyonun Aracı Rolü
Authors: Çiçek Berat , Çoban Ramazan
Published: December 2024

İş yaşamında çalışan davranışlarını olumsuz etkileyen konulardan biri olan işyeri nezaketsizliği, işyerinde saygı kurallarını çiğneyen, belirsiz bir amaçla sergilenen, iletişim esnasında karşıdaki kişiye zarar veren ve düşük yoğunluğa sahip kaba davranışlar olarak tanımlanmaktadır. Bu araştırmanın amacı, işyeri nezaketsizliğinin çalışan sessizliği üzerindeki etkisinde ruminasyonun aracı rolünü incelemektir. Değişkenler arası ilişkileri incelemek amacıyla kesitsel nicel araştırma yöntemi kullanılmıştır. Araştırma verileri, anket yöntemi kullanılarak toplanmıştır. Araştırmanın örneklemini İzmir ilinde eğitim sektöründe görev yapan 409 katılımcı oluşturmaktadır. Katılımcılardan anket yöntemiyle toplanan verilerin analizinde, Yapısal Eşitlik Modeli (YEM) yöntemi benimsenmiştir. Araştırma bulgularına göre, işyeri nezaketsizliğinin çalışan sessizliği ve ruminasyonu pozitif yönlü etkilediği; ruminasyonun ise çalışan sessizliğini pozitif yönlü etkilediği görülmüştür. Ayrıca, dolaylı etki analizi bulgularına göre çalışanların ruminatif düşüncelerinin işyeri nezaketsizliği ile çalışan sessizliği arasındaki ilişkide kısmi aracılık rolünün olduğu görülmüştür. Araştırmada elde edilen sonuçların örgütsel davranış alanında özellikle ruminasyon kavramıyla ilgili gelişmekte olan literatüre özgün katkı sağlayacağı düşünülmektedir.
The Impact of Greenhouse Gas Risks on Stock Market Returns: An Application on G7 Countries
Authors: Köycü Erol
Published: December 2024

This study investigates the impact of greenhouse gas risks on stock market returns. While carbon dioxide, methane, and nitrogen gas emissions are taken as greenhouse gases; the stock market benchmark indices of the G7 countries, which are defined as the seven most developed countries in the world, are taken as the basis for the stock market. Due to data limitations, the scope of the current study has been set as the 2000-2020 time period and the panel data analysis method has been applied. In this study, endogeneity and multicollinearity problems, cross-sectional dependence, and homogeneity/heterogeneity tests are tested respectively, and the model is estimated by performing unit root analysis in line with the findings obtained. The results of the analyses indicate that there are no endogeneity and multicollinearity problems among the variables used in the study, there is cross-sectional dependence, the variables are stationary at level I(0), there are problems of autocorrelation in the panel and it is appropriate to estimate the model with the fixed effects model. As a result of the estimation with the robust model estimator that solves the problem of autocorrelation, it is found that carbon dioxide and methane have a negative effect on stock market return, while nitrogen gas has a positive effect on stock market return. These findings suggest that investors reflect their concerns about climate change to stock markets through greenhouse gas emissions.
SOSYAL MEDYA BAĞIMLILIĞI İLE SATIN ALMA DAVRANIŞI ARASINDAKİ İLİŞKİDE FOMO’NUN ARACILIK ETKİSİ: Z KUŞAĞI ÜZERİNE BİR ARAŞTIRMA
Authors: Aktaş Öznur , Yavuzyılmaz Oğuz
Published: December 2024

Bu çalışmada sosyal medyayı yaygın kullandığı bilinen Z kuşağının sosyal medya bağımlılığı ile satın alma davranışı arasındaki ilişkide gelişmeleri kaçırma korkusunun (FOMO) aracılık etkisi incelenmiştir. Anket yöntemi kullanılarak 427 kişiden (Z Kuşağı) elde edilen veriler üç aşamalı çoklu regresyon analizi yöntemi kullanılarak SPSS PROCESS Makro eklentisi ile test edilmiştir. İlk aşamada bağımsız değişkenlerin (sanal tolerans ve sanal iletişim) ara değişken (FOMO) üzerindeki etkisine, ikinci aşamada, bağımsız değişkenlerin (sanal tolerans ve sanal iletişim) bağımlı değişken (satın alma davranışı) ile ilişkisine ve üçüncü aşamada ise bağımsız değişkenler (sanal tolerans ve sanal iletişim) ile ara değişkenin (FOMO) birlikte analize tabi tutularak bağımlı değişken üzerindeki etkisine bakılmıştır. Araştırma için geliştirilen model test edilmiş ve elde edilen bulgular ile geliştirilen toplam 8 hipotez doğrulanmıştır.
Elde edilen verilere göre; FOMO’nun satın alma davranışı üzerinde, sanal toleransın satın alma davranışı ve FOMO üzerinde pozitif ve anlamlı bir etkisi olduğu; sanal iletişimin satın alma davranışı üzerinde pozitif ve anlamlı bir etkisi olduğu; sanal tolerans ile satın alma davranışı ve sanal iletişim ile satın alma davranışı arasındaki ilişkide FOMO’nun aracı bir etkisi olduğu tespit edilmiştir.
DİJİTAL DÖNÜŞÜMÜN İNOVASYON KABİLİYETİNE ETKİSİ: META-ANALİTİK BİR ANALİZ
Authors: Karafakıoğlu Engin
Published: December 2024

Teknolojik gelişmeler ile ortaya çıkan inovasyonlar sonucunda yaşanan dijital dönüşüm gerek iş yaşamına gerekse toplumsal yaşama entegre edilerek küresel bir değişimi başlatmıştır. Kültürler bu değişime adapte olurken işletmeler de dijital teknolojilerin kullanılması ile iş süreçlerini yeniden yapılandırarak inovatif stratejiler geliştirmiştir. Dijital dönüşüm bir işletmenin iş modellerinin dijitalleşerek örgüt kültürünün dijital kültüre adapte olması ve stratejilerinin de yenilikçi olmasını ifade etmektedir. İnovasyon kabiliyeti ise işletmelerin yenilikçi ürün ve hizmetler geliştirerek uygulama yeteneğidir. Dijital dönüşüm ile aralarında güçlü bir bağ olan inovasyonun gerçekleştirilmesinde inovasyon kabiliyeti önemli bir gerekliliktir. Dijital dönüşüm işletmelere rekabet avantajı, verimlilik ve ekonomik büyüme sağlarken inovasyon kabiliyeti ise bu faydaları desteklemektedir. Bu bağlamda dijital dönüşüm ve inovasyon kabiliyeti arasındaki ilişki birbirini destekleyerek işletmelerin performanslarını olumlu yönde etkilemektedir. Bu araştırma dijital dönüşüm ve inovasyon kabiliyeti arasındaki ilişkileri literatürde yer alan farklı çalışmaların sonuçlarını bir araya getirerek bu iki kavram arasındaki ilişkiye dair etki büyüklüğünü ortaya koymayı hedefleyen meta-analiz yöntemi ile kapsamlı olarak ele alınmıştır. Yapılan çalışmada kapsama alınan çalışmalar arasında Web of Science, Google Scholar, Scopus, ProQuest, PubMed veri tabanlarından seçilen 5 eser uygun görülerek araştırmaya dâhil edilmiştir. Meta analiz sonucunda dijital dönüşüm ile inovasyon kabiliyeti arasında 0,234 değerinde ve düşük güçte bir ilişki tespit edilmiştir.
ECONOMIC INACTIVITY: SUGGESTIONS FOR TAPPING THE POOL OF POTENTIAL LABOUR FORCE IN EUROPE AND TÜRKİYE
Authors: Dinçer Gönül , Ağır Hüseyin
Published: December 2024

Labour force shortages are persistent labour market problems of both Europe and Türkiye although there is a significant pool of inactive people not participating in the labour force. Analyzing every aspect of ‘being out of labour force’ status of working age population in a country has great importance for monitoring labour market cycles, since shifts in participation in the labour force is a key determinant of economic growth. Having a direct causality with growth, empirical field literature generally focuses on unemployment segment of the labour force whereas people that are out of labour force are in some cases close in numbers to the unemployed and even more than unemployed in some other cases. Therefore the transition of people from ‘inactive but willing to work’ status to ‘active’ labour force is of vital importance. This study, motivated by these considerations, aims to fill a gap in the literature employing a model where we tested the effects of social protection expenditures per capita and GDP per capita on five different economic inactivity indicators across European countries and Türkiye in 2010-2022 using panel data techniques. Our findings indicate that cause-specific and fine-tuned policies can induce transition from inactive status to active labour force.
Rus Büyük Güç Bölgeselciliği ve Kolektif Güvenlik Anlaşması Örgütü: Stratejik Araçsallaştırma ve Sınırlılıkları
Authors: Demirtepe Mustafa Turgut , Omonkulov Otabek
Published: December 2024

Büyük Güç Bölgeselciliği kavramı, küresel aktörlerin jeopolitik çıkarlarını güvence altına almak amacıyla bölgesel örgütleri nasıl kullandıklarını analiz etmek için kritik bir çerçeve sunmaktadır. Bu makale, Rusya’nın eski Sovyet devletleri üzerindeki etkisini pekiştirmek için Kolektif Güvenlik Anlaşması Örgütü’nü (KGAÖ) kullanmasına odaklanarak KGAÖ’nün bir bölgesel güvenlik örgütü olarak işlevselliğini irdelemektedir. Başlangıçta güvenlik işbirliğini teşvik etmek için kurulan KGAÖ, giderek Rusya’nın stratejik gündemine hizmet eder hale gelmiş ve üye devletler arası ya da üye devletlerin iç güvenlik krizlerine yönelik müdahalesizlik ya da seçici müdahale politikaları nedeniyle rahatsızlığa neden olmuştur. KGAÖ’nün, üyelerinin farklı güvenlik ihtiyaçlarından ziyade Rusya’nın çıkarlarına öncelik verdiği algısı, üyeleri arasında örgütün kolektif bir güvenlik sağlayıcısı olarak etkinliğinin sorgulanmasına yol açmıştır. Makale, Rusya'nın Büyük Güç Bölgeselciliği bağlamında KGAÖ’yü araçsallaştırmasının örgütün çeşitli güvenlik kaygılarını ele alma kabiliyetini sınırladığı ve nihayetinde örgütün uyumunu ve güvenilirliğini zayıflattığını öne sürmektedir.
MODELING AND FORECASTING OF TOURISM INCOME: THE CASE OF TURKEY
Authors: Kara Gülay Begüm
Published: December 2024

This study aims to identify the optimal forecasting model for predicting Türkiye's tourism income, a crucial factor for economic planning and development. This study employs different forecasting techniques, including the seasonal Autoregressive Integrated Moving Average (SARIMA), the additive and multiplicative Holt-Winters methods, the Exponential Smoothing State Space (ETS), Artificial Neural Networks (ANNs) and seasonal-trend decomposition procedure based on the loess (STL)-ANN hybrid model and evaluates their performance. The methodology involves analyzing monthly tourism income data from January 2012 to December 2023, incorporating additional economic indicators such as the economic confidence index, number of visitors, consumer price index, industrial production index, and USD exchange rate, which serve as input for ANN models. The findings reveal that ANNs, particularly the model that incorporates tourism income alongside other economic indicators, outperform traditional models with the lowest Mean Absolute Scaled Error (MASE) and Root Mean Squared Scaled Error (RMSSE). Specifically, the ANN model with additional predictors demonstrates the highest forecasting accuracy. These results suggest that advanced machine learning techniques provide superior predictive capabilities compared to traditional linear models. The study underscores the importance of integrating complex models to achieve more accurate forecasting, offering valuable insights for policymakers and practitioners in the tourism sector.
Large-scale prediction of biological activities with Active-IT system
Authors: Almeida V.L. , dos Santos O.D.H. , Lopes J.C.D.
Published: December 2024

Traditional testing methods in pharmaceutical development can be time-consuming and costly, but in silico evaluation tools can offer a solution. Our in-house Active-IT system, a Ligand-Based Virtual Screening (LBVS) tool, was developed to predict the biological and pharmacological activities of small organic molecules. It includes four independent modules for generating molecular descriptors (3D-Pharma), machine learning modeling (ExCVBA), a database of bioactivity models, and a prediction module. Activity data collected from the PubChem BioAssay database was used for modelling SVM and Naïve Bayes machine learning methods. Models have been constructed using a recursive stratified partition method and validated through an activity randomization (Y-random) process. Over 3500 bioassays were modeled, each comprising 30 SVM and 30 Naïve Bayes models and 60 randomized models. Bioassays with low performance or discrimination between regular and randomized were discarded. Using the Active-IT system we have evaluated three bioactive compounds of Ayahuasca tea. The predictions were thoroughly validated using known targets described in several public databases. The external validation results are noteworthy, with 16 of 33 (48.5% with p-value
The effect of bitter honey against cerebral malaria-induced inflammasome cell death: network pharmacology-based in silico evaluation
Authors: Daniyan M.O. , Adeoye O.B. , Osirim E. , Asiyanbola I.D.
Published: December 2024

Cerebral malaria (CM) is a fatal complication of Plasmodium falciparum infection. The biological and physiological links between CM, inflammation, and inflammasome, point to the complexity of its pathology. Resistance to available and affordable drugs, worsening economic crisis, and urgent need for integration of orthodox with traditional/alternative medicine, actualized the search for sustainable pharmacotherapy. Previous works from our team on the medicinal properties of bitter honey have established botanical and bioactive markers, inhibitory effects on pancreatic alpha-amylase activity, and anti-dyslipidemia, cardio-protective, and ameliorative effects on hepatorenal damage in streptozotocin-induced diabetic rats. In this study, we have identified bitter honey (BH) derived phytochemicals using gas chromatography coupled with mass spectrometry (GC-MS), and 9 targets from genes associated with CM, inflammation, inflammasome, and BH phytochemicals. Network analysis revealed significant functional and physical interactions among these targets and NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3). Molecular docking of bitter honey-derived phytochemicals against these targets identified 3 most promising phytochemical candidates for further experimental validation. Based on these results, we predict that bitter honey may aid in the suppression of CM-mediated inflammasome cell death via its interactions with these targets.
History in Motion Nūr al-Dīn al-Rānīrī’s Retelling of ʿAbbāsid History in Seventeenth-Century Aceh
Authors: Meyer Verena
Published: December 2024

This article focuses on the seventeenth-century Islamic scholar Nūr al-Dīn al-Rānīrī (d. 1658), who became especially known for his harsh oppression of monistic Sufism during his tenure as Shaykh al-Islām at the Acehnese court. Yet, some indications suggest that Rānīrī’s opposition to Sufism was not as clear-cut as it first seems. Revisiting a thus-far unanswered question about a strange idiosyncrasy in Rānīrī’s magnum opus, a universal history in Malay titled Bustān al-Salāṭīn, this article seeks to dislodge simplistic understandings of the legitimacy of certain strands of Sufism, the polemics around charges of being “monistic,” and Rānīrī’s own positionality.
The role of social media in promoting voluntary blood donation during disasters: a short communication of the Lagos State bus-train collision
Authors: Osikomaiya Bodunrin I. , Orolu Adebukola K. , Adeyemi Oluwatosin I. , Animashaun Olayinka G. , Ojabowale Araromi O. , Abimbola Oni O.
Published: December 2024

Lagos State experienced a mass casualty involving a bus and a moving train on 09 March 2023. Despite only 0.58% of Lagos’s population donating blood, the Lagos State Blood Transfusion Services (LSBTS) leveraged Twitter, community outreach and blood collection centre expansion, to mobilize voluntary blood donors and meet the sudden increased demand. This short communication describes the role of social media, in driving community engagement during disasters, while assessing changes in blood donation patterns and evaluating donor awareness. Within one hour of the disaster, the LSBTS official Twitter handle, posted information about the critical need for blood including, locations of designated donation centres. Number of likes, retweets and views of the post was monitored daily over five days. Information on first-time donors, donor deferrals and donation campaign awareness were captured from the donor registration form. The LSBTS records were assessed for changes in pre and post disaster donation patterns. Over five days, Twitter engagements reached a historic milestone of 3966 retweets, 1953 likes and 296,446 views, driving 70.4% of donor awareness. Compared to an average of 48 individuals recruited per donation drive, 372 voluntary donors were recruited on day 1, an increase of 87.1%. Additionally, 849 donors were recruited during the disaster response, comparable to eight weeks of routine collection. A deferral rate of 32. 7% was noted with 65% being first time donors. Effective public communication remains crucial for donor recruitment and overall operational efficiency in regions aiming to improve disaster-response readiness in blood transfusion.
Effectiveness of hysterectomy in endometriosis treatment
Authors: Jaiswal Anshu , Dube Anushka S. , Kaushik Jatin , Upadhayay Kalpana , Kushwaha Aman
Published: December 2024

A preliminary investigation into endometriosis risk factors, the majority of cases of endometriosis occur in reproductive-aged women. Subfertility, dysmenorrhea, and pelvic discomfort are the main symptoms. Ovarian cysts and other non-gynecologic causes can cause persistent pelvic pains. Age at menarche and cycle duration are two additional menstrual risk variables associated with endometriosis. The likelihood of endometriosis is greater in the majority of epidemiologic investigations that have examined the subject, which typically defines early menarche as occurring before or at the age of 11. A shorter cycle duration, commonly defined as 27 days or less, most of these research, along with others, have found that is linked to an increased risk. Period length and heavy flow are areas where there is less conclusive data. Given that endometriosis risk factors include early menarche and short cycles; endometriosis's pathophysiology can be better understood by delving into the underlying physiological reasons for these problems.
Marham-i-raal: a natural multifaceted formulation for enhanced wound healing
Authors: Ansari Kausar , Rizwan Mohammad , Alam Javed , Husain Mohammad A.
Published: December 2024

A wound is a disruption in the skin's or mucous membrane's integrity caused by mechanical, chemical, or thermal injuries. The wound healing is complex and involves three overlapping stages: inflammation, proliferation, and tissue remodeling. The duration of healing of a wound can vary, and several factors may influence this process, potentially leading to delays or suboptimal healing outcomes. To address wounds and facilitate healing, various topical and systemic treatments, including antiseptics, antibiotics, antifungal, and analgesics, are utilized. In Unani System of Medicine wound is described as ‘Tafarruq-i-Ittiṣāl’ (loss of continuity) called ‘Jarāḥat’. Marham-i-Raal is in use for centuries and has wonderful effects in Qurūḥ-i-Muzmina (chronic wounds), Qurūḥ-i-Jarāḥiyya (surgical wounds), Shiqāq al-Maq‘ad (fissure in ano) and in other skin conditions like- Nār Fārsī (eczema), and Qūbā (dermatophytosis). It is valued for its effectiveness, affordability, and minimal side effects. This potent remedy is particularly beneficial for chronic ulcers, providing intensive and rapid therapeutic responses. This review explores the properties of Marham-i-Raal based on classical Unani literature and contemporary scientific research. An in-depth examination of research articles and significant scientific data from sources such as Google Scholar, PubMed, and ResearchGate was conducted. The findings indicated that Marham-i-Raal is a highly effective and safe wound healing preparation with potent desloughing, antimicrobial, antiviral, antiseptic, and antifungal properties.
Stem cell therapy: a promising solution for type 2 diabetes in Pakistan
Authors: Athar Zoya , Mudassar Misha , Muzammil Anam
Published: December 2024

The World Health Organization (WHO) has reported that non-communicable diseases (NCDs) are responsible for 58% of deaths in the Pakistani community. Diabetes mellitus being among the top four NCDS contributing to the stated percentage. It has been stated that 16.98% of Pakistan's population has fallen victim to type II diabetes mellitus, hence demanding the need for effective and innovative measures.
Irreparable subscapularis: Guide for surgeons
Authors: Corthouts Jerome , Nadjmi Julie , Glabbeek Francis Van , Brouwers Dennis
Published: December 2024

The subscapularis (SSC) muscle, one of the four rotator cuff (RC) muscles, plays a crucial role in balancing and moving the shoulder. Cases of irreparable SSC tears are difficult entities within shoulder surgery. Different techniques have been suggested with different outcomes but with no golden standard these days. Musculotendinous transfers, anterior capsular reconstruction (ACR), shoulder arthroplasty and even arthrodesis are the current options available. This article provides a review of existing literature on this entity, covering clinical work-up, operative possibilities, techniques, and rehabilitation.
A prospective study to compare the outcome of patellar fractures treated with tension band wiring versus cannulated cancellous screws fixation
Authors: Yadav Vinod Ramlal , Jyothsna Rachuru Venkata , Ravindran Biju
Published: December 2024

The largest sesamoid bone in the body, the patella, is essential to the stability and functionality of the knee. It functions as a fulcrum to adhere to the patellar ligament and quadriceps tendon, increasing the quadriceps' effectiveness. Both static elements (ligaments and the joint capsule) and dynamic elements (muscles such as the hamstrings and quadriceps) are necessary for patella-femoral stability. Both direct trauma and indirect causes, such as falling when your quadriceps are clenched, can result in fractures. While direct blows might result in comminution and soft tissue injury, indirect injuries usually cause damage to the tendons or bones.There are different ways to treat fractures. For fractures with less than 2 mm displacement, non-operative treatments can be used. Surgical alternatives include screw fixation, tension band wiring and partial or complete patellectomy.

It is a comparative randomized control trial.The purpose of this study is to evaluate the cannulated cancellous screws techniques in terms of safety and outcome when compare to tension band wiring for treatment of displaced transverse patellar fractures.

A longitudinal observational study was carried out in the department of orthopaedics for a time period of 20 months from November 2020 to June 2022. Patients were divided into two groups one treated with cannulated cancellous screws and another treated with tension band wiring then followed up at intervals of 1st, 3rd and 6 month Results were evaluated with regard to union rate, ROM, pain score, functional outcome, complications and hardware removal rates.

The mean radiological union was 9.2 weeks in cannulated cancellous screws group and 9.73 weeks in tension band wiring group, The mean knee ROM was 135° in cannulated cancellous screws Group and 129° in tension band wiring group andfunctional score in cannulated cancellous screws group was 66.7% excellent, 26.6% good and 6.7% poor outcomes. In tension band wiring group functional score was 46.6% excellent, 40% good and 13.4% poor outcomes as per WEST’S Criteria. Complications encountered in tension band wiring group were more with respect to hardware prominence, soft tissue irritation and hardware removal rates than cannulated cancellous screws group.

Cannulated cancellous screws for treatment of displaced transverse patella fracture are safe and biomechanically stable implant with lesser degree of soft tissue irritation when compared to tension band wiring.
Sexuality amongst adolescents in present era: An observational cross sectional study
Authors: Verma Divya , Agarwal Anand Kumar , Singh Srishti , Singh Saurabh Kumar , Sharma Keshav
Published: December 2024

Every individual goes through the storm and stress of intense physical and mental changes during adolescence. Awareness and knowledge about sexuality and sex during this crucial phase decides the pattern and style of their life. Gen Z has been raised in era of internet revolution. In the absence of nationwide comprehensive sexual education curriculum in schools, digitalization opens up numerous platforms of learning regarding the sexuality.

To determine the knowledge among rural and urban adolescents regarding sexuality, safe sex and their source of information. 

An observational cross-sectional study was conducted in 2 co-educational rural and urban schools each of Sitapur district on 553 students aged 12-18 years of either sex. A self-report questionnaire was administered to test their knowledge and perception regarding sex and sexuality and source of information. Data was analysed using Epi Info7. Categorical variables were expressed as number and percentage.

In present study rural adolescent has lesser number of opposite sex friends than urban counterpart. They have more physical groups while urban adolescents have more online groups. The preferred mode of interaction among urban adolescents is digital media. Lesser number of rural adolescents have knowledge about methods of safe sex, route of transmission and prevention of HIV. Major source of information was digital platform among urban adolescents.

There is knowledge gap among adolescents from rural area in present study due to social barriers and less access to internet. Thus, in this present era emphasis should be on proper sex education through different digital platforms which can play a pivotal role in delivering the facts about sexuality and appropriate grooming of adolescents.
Evaluation of febrile neutropenia in diagnosed cases of acute lymphoblastic leukemia in children
Authors: Gupta Nikhil , Sharma Novneet , Jamwal Mona , Digra Sanjeev K , Parihar Ravi Kumar
Published: December 2024

Febrile neutropenia is a serious and most common complication of cancer therapy. A single oral temperature of greater than or equal to 101 F, or a temperature of greater than or equal to 100.4 F for at least an hour with ANC <500/µL, or less than 1000/µL with a predicted fall to less than 500/µL in the following 48 hours, are the criteria for its clarification.

is to study clinical profile of febrile neutropenia in ALL patients and to study the susceptibility patterns of pathogens and bacterial spectrum in culture positive febrile neutropenic patients in ALL.

It was a retrospective study.

Patients undergoing treatment and meeting the criteria for Febrile Neutropenia were included in study.

The study was a retrospective that lasted a year. Children with febrile neutropenia undergoing chemotherapy were included in the research. The study emphasize the common infectious agents, their antibiotic sensitivity pattern. ANC being the most important parameter it was found that 15 patients (37.5%) had ANC <500/ microL and 25 patients (62.5%) had ANC between 500-1000 /microL which had fallen to <500/microL in next 24 hours.

: Long-term neutropenia was linked to an increased risk of FN, and infections with a preponderance of Gram-negative bacteria were found in about 32.5% of patients.
Continuous cardiotocography in active labour has no added advantage over intermittent fetal heart rate auscultation in low risk pregnancies
Authors: Das Sourav , Sinha Tiasa , Sarkar Suvobrata
Published: December 2024

This study is to compare the maternal and perinatal outcome in cardiotocograph monitored labour with labor monitored by intermittent auscultation in respect to mode of delivery, maternal well-being, maternal comfort, accurate detection of fetal distress by detecting cord blood acidosis, neonatal ICU admissions and perinatal death in low obstetric risk group mothers.

This was a randomised controlled prospective study at a tertiary medical College, selecting 100 cases (with CTG monitoring) and 100 controls (with FHS auscultation only) who were followed up in respect of the above parameters and statistically analysed.

The study showed there is 1.5 times higher rate of C-section in the CTG group and 1.33 times higher risk of caesarean section for abnormal FHR pattern in the CTG group. In our study, there is 1.33 times higher instrumental delivery rate in CTG group than FHS auscultation group. There was 6.39 times more complaints of discomfort in ctg monitored cases, p value-<0.0001. The sensitivity of ctg in detecting distressed babies comes nearly 100%, whereas its specificity comes to 97.8% when cord blood acidosis is taken as the marker for distressed babies. Whereas the sensitivity of auscultation group comes to 87.5%, but the specificity comes to 100%. Nursery admission rates and perinatal death rate of both the groups were same.

The study shows that in low obstetric risk patients, there is no significant difference in most of the parameters though our study showed an increased risk of caesarean sections and instrumental vaginal deliveries. It is undoubted that ctg has better detection ability for fetal heart rate abnormality. The neonatal outcome i.e the nursery admission rates and the perinatal mortality rates were also not different in both the groups.

In a country like ours or other developing countries, where resources are poor, and ctg requiring trained personnel, one to one care, ctg has not been cost effective in comparison to intermittent auscultation rather IA has sometimes outweighed ctg in terms of fetal heart rate monitoring efficiently.
A comparative study of life events in depressive patients and schizophrenia
Authors: Hyder Shafeen , Ashoka  , Janardanan Jishnu , Santhosh Rithwik
Published: December 2024

The etiology of psychiatric illnesses is mostly multifactorial. Role of life events preceding the onset of depressive disorders is well known while the role of life events in schizophrenia is a topic of debate since decades. In this study, we aim to compare the presence of life events before the onset of illness in both these diagnostic categories, among a rural population in South India.

This study was done in a tertiary medical centre in rural India, after getting ethical clearance from the institution. Participants in both groups were enrolled after getting informed consent. A semi-structured questionnaire was used to collect the socio-demographic details. Presumptive stressful life events scale (PSLES) was used to collect data from participants from both the groups, each containing 46 participants who were meeting the inclusion and exclusion criteria. Data was entered in Microsoft excel and analyzed using Epi-info software. Z-test was used for statistical measurements.

The presence of stressful life events before the onset of illness was significantly higher in the depression group. The average time lag between the stressor and onset of the disorder was around 2.74 months in the depression group while it was around 5.54 months in the schizophrenia group. The most commonly reported life events were family conflict, large loan, marital conflict, son or daughter leaving home and illness in family members.

Although literature suggests that life events play an important role in precipitation and relapse of psychiatric disorders, this relationship is not straight forward. The relationship between stress and illness varies with preexisting vulnerability factors. Stress management, healthy living habits, skill training for all individuals should be emphasized on to strengthen coping skills. Future research may focus on other intervening variables in order to reduce the incidence of stress induced illnesses.
Laconismos de resonantes adagios o principios procesales en la praxis romana: impacto y vigencia procesal ecuatoriana
Authors: Gil Osuna Bartolomé , Santacruz Cruz Hugo Bayardo
Published: December 2024

Muchas razones inspiran este análisis, pero la causam motivarum de este estudio fue el hecho de considerar que adagium y principium de los egregios iuris-prudentes romanos contribuyen hoy a la razonabilidad, argumentación y motivación de veredictos en que se dilucidan y ponderan derechos fundamentales; como lo fueron en su época antigua, en que la escasez de un derecho escrito y de una interpretatio positiva propia de los magistrados, realzó su proyección jurídica y su finalidad epidíctica. Por tanto, el principio dura lex, sed lex —la ley es dura, pero como ley debe cumplirse como tal— y el aforismo semper in dubiis benigniora praeferenda sunt —que establece la preferencia por la interpretación más benigna en caso de duda normativa—, constituyen pilares fundamentales que continúan permeando la praxis procesal ecuatoriana contemporánea. Estos procesos siguen incidiendo en la argumentación y resolución de casos judiciales.
Cross-border Tobacco Smuggling: Case Study of Eastern Macedonia and Thrace Region of Greece
Authors: Theologi Vasiliki
Published: December 2024

This policy article examines tobacco smuggling as a manifestation of cross-border crime in the Eastern Macedonia and Thrace region of Greece. It explores the socio-economic and legal factors contributing to the phenomenon and provides insights from case studies and data analysis. Findings indicate that enhanced regional cooperation and stricter law enforcement measures are critical for combating this issue. The article suggests that a holistic, technology-driven, and collaborative approach is critical to combating this lucrative cross-border crime.