bluuebunny/crossref_metadata_2025 huggingface dataset:
Going from 3D Common-envelope Simulations to Fast 1D Simulations
Authors: Bronner Vincent A. , Schneider Fabian R. N. , Podsiadlowski Philipp , Röpke Friedrich K.
Published: December 2024

One-dimensional (1D) methods for simulating the common-envelope (CE) phase offer advantages over three-dimensional (3D) simulations regarding their computational speed and feasibility. We present the 1D CE method from Bronner et al. (2024, DOI: 10.1051/0004-6361/202347397), including the results of the CE simulations of an asymptotic giant branch star donor. We further test this method in the massive star regime by computing the CE event of a red supergiant with a neutron-star mass and a black-hole mass companion. The 1D model can reproduce the orbital evolution and the envelope ejection from 3D simulations when choosing suitable values for the free parameters in the model. The best-fitting values differ from the expectations based on the low mass simulations, indicating that the free parameters depend on the structure of the giant star. The released recombination energy from hydrogen and helium helps to expand the envelope, similar to the low-mass CE simulations.
High-mass X-ray Binaries in Milky Way/Andromeda-like Galaxies
Authors: Vivanco Cádiz Felipe , Artale M. Celeste , Masetti Nicola , Escobar Gastón J. , Iorio Giuliano
Published: December 2024

High-Mass X-ray Binaries (HMXBs) are important for the study of the evolution of massive stars, the formation of compact objects such as black holes (BH) and neutron stars (NS), and the binary evolution processes that govern these systems. Moreover, HMXBs are crucial for understanding the accretion processes responsible for X-ray emission and are also potential progenitors of gravitational wave (GW) sources. In this study, we explore the population of HMXBs within simulated MW/M31-like galaxies by employing the IllustrisTNG50 hydrodynamical simulation in combination with the SEVN population synthesis code. We populate these galaxies with HMXBs by selecting stellar particles based on spatial location, metallicity, and age, accounting for the effects of varying metallicities and binary evolution processes. Our results indicate that the number and luminosity of HMXBs are significantly influenced by metallicity, confirming previous findings. Furthermore, we reproduce the expected slopes of the X-ray luminosity function (XLF), as well as the orbital parameters and masses of these systems, finding that the power-law slope α of the XLF is within the observed range and consistent with Galactic observational data.
Mass Transfer in High-mass X-Ray Binaries: from Roche Lobe Overflow to Hoyle–Lyttleton Accretion
Authors: Blondin John M.
Published: December 2024

We use a new overset dual spherical grid system to evolve the circumstellar gas flow in the High-Mass X-Ray Binary Vela X-1 to investigate the gravitational capture of the donor star’s wind and subsequent accretion onto the neutron star companion. For a fast, relatively undistorted stellar wind (small filling factor) we find results consistent with classical Hoyle–Lyttleton accretion with the formation of a steady, nearly axisymmetric bow shock. For models with a filling factor near unity, the mass transfer is dominated by a tidal stream feeding into a thin accretion disk. Finally, for slow winds without Roche Lobe Overflow we find the formation of a wind bow shock but with enough post shock angular momentum to form a thin, stable accretion disk.
Compact Objects with Wolf–Rayet Companions: a Key Binary Configuration to Produce Gravitational Wave Mergers
Authors: Korb Erika
Published: December 2024

The properties of binaries hosting a Wolf–Rayet star and a compact object (black hole or neutron star) suggest that such systems could be the progenitors of binary compact objects merging via gravitational wave emission. We used the population-synthesis code SEVN to explore this possibility and account for current uncertainties in theoretical models. According to our simulations, most (more than about 83%) binary compact object mergers were once compact objects with Wolf–Rayet companions. Binaries like Cyg X-3, the only candidate hosting a Wolf–Rayet and a compact object observed in the Milky Way, are more likely (approximately 70%–100%) to become binary compact object mergers if they host a black hole. This work indicates that further characterization of systems like Cyg X-3 can unveil the formation mechanisms of binary compact object mergers.
Компьютерное моделирование динамики населения городского образования
Authors: Иновенков И.Н. , Нефедов В.В. , Тихомиров В.В.
Published: December 2024

В предлагаемой статье методами математического моделирования изучается проблема совместного сосуществования различных групп городского населения. В простейшем случае рассматривается только взаимодействие двух групп населения внутри одной городской территории. На качественном уровне такая задача может быть описана системой двух нестационарных и нелинейных дифференциальных уравнений диффузионного типа с граничными условиями третьего рода. Результаты проведенного численного моделирования показывают, что при соответствующем выборе коэффициентов диффузии и функций взаимодействия между различными группами населения можно получить различные сценарии динамики численности городского населения: от полного вытеснения одной группы населения другой (изначально более «агрессивной») до ситуации «мирного» совместного сосуществования.

In this paper using a mathematical model of the so-called "space-dynamic" approach we investigate the problem of development and temporal dynamics of different urban population groups. For simplicity, we consider an interaction of only two population groups inside a single urban area with axial symmetry. This problem can be described qualitatively by a system of two non-stationary nonlinear differential equations of the diffusion type with boundary conditions of the third type. The results of numerical simulations show that with a suitable choice of the diffusion coefficients and interaction functions between different population groups we can receive different scenarios of population dynamics: from complete displacement of one population group by another (originally more "aggressive") to the "peaceful" situation of co-existence of them together.
ИНСТРУМЕНТАЛЬНЫЕ НАБЛЮДЕНИЯ ЗА ДЕФОРМАЦИЯМИ ЗДАНИЯ В ОБЛАСТИ ВЛИЯНИЯ СТАРЫХ ГОРНЫХ РАБОТ
Authors: Прошин Владислав Александрович
Published: December 2024

Объектом исследования является трехэтажное здание, построенное в 2011 г. на подработанной горными работами территории начала 20 века. Перед строительством здания в 2011 г. были проведены специальные исследования грунтов, которые позволили сделать вывод о том, что застройка земельного участка безопасна. Тем не менее построенное здание постоянно деформируется, в стенах образуются трещины с раскрытием до нескольких миллиметров, а на территории вокруг здания периодически образуются просадки грунта. Цель работы - установление причины деформации здания. Методы исследования: геодезические инструментальные наблюдения за смещениями стенных реперов с помощью нивелирования III класса точности, анализ горно-геологических материалов, визуальные наблюдения за деформациями здания. Сделан вывод о наличии целого комплекса факторов, влияющих на деформацию здания, а именно: литологическое разнообразие суглинков и глин, имеющих различные физико-механические свойства, вероятное наличие оставшихся пустот и участков разуплотнения вследствие влияния горных работ, конструктивные недостатки самого здания.

The object of the study is a three-story building built in 2011 on the territory that used to be mined by the underground works at the beginning of the 20th century. Special soil studies were carried out before the construction of the building in 2011, which made it possible to conclude that the development of the land plot is safe. However, the constructed building is being constantly deformed, cracks form in the walls with an opening of up to several millimeters, and soil subsidence periodically occurs in the area around the building. The purpose of the work is to establish the cause of the deformation of the building and assess the safety of the operation of the social facility. Research methods: geodetic instrumental observations of displacements of wall benchmarks using leveling of the 3rd class of accuracy, analysis of mining and geological materials, visual observations of building deformations. The analysis concluded that there is a whole range of factors affecting the deformation of the building, namely: the lithological diversity of loams and clays with different physical and mechanical properties, the likely presence of remaining voids and areas of decompaction due to the influence of mining, structural shortcomings of the building itself.
ОЦЕНКА ПЕРСПЕКТИВ КОМПЛЕКСНОГО ОСВОЕНИЯ МИНЕРАЛЬНЫХ РЕСУРСОВ УРАЛА
Authors: Титов Роман Сергеевич , Кантемиров Валерий Даниилович , Яковлев Андрей Михайлович
Published: December 2024

Комплексное освоение месторождений полезных ископаемых является приоритетным направлением совершенствования горного дела, включающим максимально возможное извлечение основного ценного компонента полезного ископаемого, а также изыскание технико-технологических решений по извлечению попутного минерального сырья. Приведены результаты лабораторных исследований титаномагнетитовых руд и хвостов обогащения, а также техногенных образований Челябинской обл. Представлены результаты оценки ряда вскрышных горных пород ОАО «Ураласбест» (перидотит, диорит, габбро и серпентинит) на предмет соответствия их физико-механических свойств требованиям нормативных документов для использования при производстве щебня. Обобщена информация о техногенных образованиях Урала и возможности их освоения с целью извлечения ценных компонентов и производства строительных материалов. Реализация предложенных мероприятий позволит увеличить загрузку горнодобывающего и обогатительного оборудования действующих производств, позволит обеспечить более рациональное использование недр и земельных угодий, увеличить объемы валовой продукции и номенклатуры товарной на действующих горных предприятиях без существенного расширения производственных площадей, а также сокращение площадей, отводимых под отвалы, и затрат на складирование скальных пород и содержание отвального хозяйства, снижение транспортных расходов.

Complex development of mineral deposits is a priority area of mining improvement, including the maximum possible extraction of the main valuable component of the minerals, as well as the search for technical and technological solutions for the extraction of concomitant mineral raw materials. The article presents the results of laboratory studies of titanomagnetite ores and enrichment tailings, as well as of technogenic formations of the Chelyabinsk region. The paper presents results of the evaluation for a number of overburden rocks on Uralasbest enterprise (such as peridotite, diorite, gabbro and serpentinite) for compliance of their physical and mechanical properties with the requirements of regulatory documents for use in the production of crushed stone. It summarizes the information about the technogenic formations of the Urals and the possibility of their development in order to extract valuable components and produce building materials. The implementation of the proposed measures will increase the utilization of mining and processing equipment on existing production facilities, it will allow more rational use of subsoil and land and increase the volume of gross output and commodity nomenclature at existing mining enterprises without significantly expanding of their production areas, as well as reducing the areas allocated for dumps and the cost of storing rocks and maintenance dump economy, reduction of transport costs.
Polymorphism of the microsomal epoxide hydrolase EPHX1 gene (rs1051740) in often ill children living in the industrial region of southern Siberia
Authors:   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Zaitseva N.V. , Dolgikh O.V. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Subbotina A.A. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Yaroma A.V. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Published: December 2024

The aim of the study was to analyze frequency of the EPHX1 gene polymorphism (rs1051740) associated with diseases of the upper airways and elevated manganese levels in biological media of children from an industrial area located in the Southern Siberia.
Materials and methods. We examined children aged 4-7 years who permanently lived in an industrial area in the Southern Siberia. It was a monotown with its economy dominated by a large non-ferrous metallurgy plant. The test group was made of 60 children who were often sick (more than 6 times a year) for a long time. The reference group included 39 conditionally healthy children with manganese levels in their blood being within the reference range. We identified frequency of polymorphism of the microsomal epoxide hydrolase EPHX1 gene (rs1051740) and the cytochrome C level using PCR and ELISA accordingly. The statistical significance was taken at p<0,05.
Results and discussion. Average manganese levels were 1,8 times significantly higher in blood of the children from the test group than in the reference one. We established statistically significant authentic differences in frequencies of the EPHX1 gene genotypes and alleles (rs1051740) between the test and reference groups (the C/C genotype was 3,2 times more frequent; the С allele, 1,5 times, p<0,05). Cytochrome C levels were 2,2 times lower in blood serum in the test group against the reference one.
Conclusions. The study established several peculiarities in children who often had diseases of the upper air ways (the test group). They had elevated manganese levels in their blood, higher than its safe level; the serum cytochrome C level was lower in them; they more frequently had the C/C genotype (OR=4,05, 95% CI=1,26-13,05) and the С allele (OR=1,98, 95% CI=1,09-3,60) of the EPHX1 gene (rs1051740). Many authors believe polymorphism of this gene to be a risk factor able to cause respiratory diseases. Deficiency of microsomal epoxide hydrolase 1, combined with the candidate gene polymorphism, disrupts detoxification, promotes accumulation of non-conjugated chemical exogenous factors (manganese), inhibits anti-oxidation and weakens the immunity. All this makes children who live in the analyzed town fall sick with respiratory diseases more frequently.
Keywords: xenobiotic biotransformation, the EPHX1 gene polymorphism (rs1051740), respiratory pathology, detoxification genes, manganese contamination in biological media.
Comparative analysis of thermal imaging pictures of Northerners in the age aspect
Authors:   Scientific Research Center “Arktika” of the Far Eastern Branch of the Russian Academy of Sciences, Averyanova I.V. , Vdovenko S.I. ,   Scientific Research Center “Arktika” of the Far Eastern Branch of the Russian Academy of Sciences
Published: December 2024

Four hundred and fifty-two male residents of Magadan Region were examined to study ontogenetic features in their thermal imaging pictures. Based on the subjective age which ranged 15-74, four groups were formed: adolescents, young men, mature men, and elderly men. The indicators of thermography, hemodynamics, gas exchange and energy metabolism were analyzed We could see the temperatures in both individual zones of the body and weighted averages through all analyzed spots drop in increasing reliance on age. The daily energy consumption at rest, oxygen consumption per kg of the body weight, as well as the oxygen utilization factor were also maximal in the group of young men and minimal in older men. The average group indices of peripheral vascular resistance increasingly varied from adolescents to the elderly, while the cardiac output values dropped in more than half within the same age range.
Keywords: thermography, metabolism, hemodynamics, North, men, adaptation.
The relationship of parameters of the pituitary-gonadal axis and dopamine with meteorological factors in healthy men living in the Subarctic
Authors:   N. Laverov Federal Center for Integrated Arctic Research, Molodovskaya I.N. , Tipisova E.V. ,   N. Laverov Federal Center for Integrated Arctic Research, Elfimova A.E. ,   N. Laverov Federal Center for Integrated Arctic Research, Alikina V.A. ,   N. Laverov Federal Center for Integrated Arctic Research, Zyabisheva V.N. ,   N. Laverov Federal Center for Integrated Arctic Research
Published: December 2024

Aim: to evaluate the influence of circannual dynamics of meteorological factors of the temperate continental climate on the levels of sex hormones and dopamine as well as antisperm antibodies in men living in subarctic environmental conditions.
Materials and methods. The concentrations of follicle stimulating hormone, luteinizing hormone, prolactin, progesterone, dopamine, cortisol, total and free testosterone, estradiol, sex hormone-binding globulin, dehydroepiandrosterone sulphate, antisperm antibodies were determined in the blood by the enzyme immunoassay on a quarterly basis (December, March, June, September) for one year in 20 healthy men of Arkhangelsk. The relationships between the hormonal data and the climatic data were assessed by using the Spearman correlation coefficient.
Results. Seasonal fluctuations in the levels of estradiol and antisperm antibodies are comparable to changes in the daylight hours, fluctuations in atmospheric pressure, temperature and relative humidity. Seasonal changes in luteinizing hormone levels are associated with the fluctuations in atmospheric air pressure. Daylight affect annual dopamine dynamics, which also correlated with atmospheric pressure and relative air humidity. Total and free testosterone levels in men are relatively constant throughout the year and do not appear to be influenced by the weather factors.
Conclusion. An increase in day length and air temperature is associated with an increase in estradiol and dopamine levels and a decrease in antisperm antibodies values. We believe that the seasonality of estradiol and antisperm antibodies is a daylight effect mediated by changes in the melatonin levels, just as dopamine seasonality is mediated by changes in vitamin D levels.
Keywords: sex hormones; circannual rhythm; dopamine; estradiol.
Modern concepts about apoptosis
Authors:   N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Institute of Physiology of Natural Adaptations, Patrakeeva V.P. , Kontievskaya E.V. ,   N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Institute of Physiology of Natural Adaptations
Published: December 2024

The review is devoted to the generalization of modern knowledge about such a type of cell death as apoptosis. To date, it is known that apoptosis is not just a programmed cell death that ensures the elimination of old cells with minimal damage to surrounding tissues, but it is also a complex mechanism that can promote survival and proliferation, as well as induce and suppress the inflammatory process. Drugs that cause enhanced apoptosis are being actively studied for the treatment of oncological diseases. The mechanisms of cell death selection are still being studied, but it is already known that weak effects on the macroorganism promote the activation of apoptosis and autophagy, while stronger effects promote necrosis. Low levels of apoptosis contribute to the accumulation of damaged cells, aging, and genome instability. Reduced accumulation of senescent cells improves homeostasis and lifespan.
Keywords: apoptosis, apoptotic bodies, caspases.
The role of the BDNF (rs6265) and CNTF (rs1800169) gene polymorphic variants in the development and progression of neurological disorders
Authors:   East-Siberian Institute of Medical and Ecological Research: Angarsk, RU, Bodienkova G.M. , Shchepina M.O. ,   East-Siberian Institute of Medical and Ecological Research: Angarsk, RU
Published: December 2024

In recent decades the contribution of polymorphic variants of genes encoding neuroinflammation and neuroprotection proteins in pathology of the nervous system has been actively studied. Numerous studies have demonstrated the most important structural and functional role of single nucleotide variants in the BDNF and CNTF genes in the brain. This review provides evidence of the association of polymorphic loci of the BDNF and CNTF genes with a number of neurological disorders. It was found that an increased risk of developing depressive disorders, Alzheimer's and Parkinson's diseases are characteristic of the BDNF rs6265 polymorphism carriers. Moreover, the above mutation affects the length of stay in rehabilitation and the duration of remission in patients with substance dependence. A number of authors provide contradictory information about the relationship of the BDNF rs6265 genetic variant with changes in neurotrophin levels in schizophrenia. The BDNF rs6265 A/A genotype carriers in Caucasian and Asian populations showed an increased risk of the disease. The CNTF rs1800169 genetic variant does not affect the risk of schizophrenia in general but may play a more prominent role in its clinical manifestations together with other CNTF gene mutations. Some studies have shown an association of the rs1800169 polymorphism in the CNTF gene with schizophrenia spectrum disorders. A number of studies have confirmed a negative association between the rs1800169 polymorphism in the CNTF gene and Alzheimer's disease. Further studies are needed to clarify the role of the BDNF and CNTF genetic variants in pathology of the nervous system and to find an effective treatment.
Keywords: brain-derived neurotrophic factor, ciliary neurotrophic factor, the BDNF gene, the CNTF gene, SNP markers, genetic predisposition, neurological disorders.
The level of endogenous intoxication in overweight individuals
Authors:   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Nikolaev V.M. , Sofronova S.I. ,   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Tomtosova E.V. ,   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Rumyantsev E.K. ,   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Sleptsova N.A. ,   PhD in Agriculture, Associate Professor, Head of the Department of Agronomy and Chemistry
Published: December 2024

According to the data obtained, there is an increase in the levels of low and medium molecular weight substances and oligopeptides in plasma, erythrocytes, and urine, depending on body weight. In obese individuals, there was a significant increase in the concentrations of low and medium molecular weight substances and oligopeptides compared to those with normal body weight in all biological samples studied, indicating endogenous intoxication in the body of obese individuals.
Keywords: low and medium molecular weight substances, oligopeptides, obesity, overweight, endogenous intoxication.
Особенности процессуального принуждения, применяемые к субъектам предпринимательской деятельности
Authors: Астахова К.А.
Published: December 2024

В статье выделены основные признаки и функции предпринимательской деятельности, а также факторы, указывающие на специфику избрания мер процессуального принуждения к субъектам предпринимательства при нарушении ими законодательства. Отмечается общая тенденция смягчения мер процессуального принуждения при нарушении правовых норм субъектами предпринимательской деятельности с целью создания благоприятного делового климата в стране. Автором использован сравнительно-правовой подход к рассматриваемой проблеме в России, Китае и некоторых странах Востока.

The article highlights the main features and functions of entrepreneurial activity, as well as factors indicating the specifics of choosing measures of procedural coercion against business entities when they violate the law. There is a general tendency to soften measures of procedural coercion in case of violation of legal norms by business entities in order to create a favorable business climate in the country. The author used a comparative legal approach to the problem under consideration in Russia, China and some Eastern countries.
Меры административно-процессуального принуждения, применяемые полицией в области дорожного движения
Authors: Трегубов И.С.
Published: December 2024

В статье рассматриваются меры административно-процессуального принуждения, цель которых — создать условия для привлечения нарушителей правил дорожного движения к административной ответственности. Автор исследует нормативное закрепление таких мер, как освидетельствование и медицинское освидетельствование на состояние опьянения, задержание транспортного средства нарушителя, а также практику реализации этих мер, и формулирует предложения по совершенствованию реализации рассматриваемых мер в деятельности полиции.

The article discusses measures of administrative procedural coercion, the purpose of which is to create conditions for bringing violators of traffic rules to administrative responsibility. The author examines the regulatory framework for such measures as examination and medical examination for intoxication, detention of the violator’s vehicle, as well as the practice of implementing these measures, and formulates proposals for improving the implementation of the measures in question in police activities.
Компетенция арбитражного суда по делам с участием органов, осуществляющих публичные полномочия.
Authors: Кузьмина А.В.
Published: December 2024

По мнению автора, арбитражное и гражданское процессуальное законодательство нуждается в дальнейшем реформировании в части разграничения компетенции арбитражных судов и судов общей юрисдикции. В статье на основании анализа текущей судебной практики показано, что критерии субъектного состава участников спора и характера спорного правоотношения не позволяют с должной степенью определенности отнести к полномочиям различных судов дела с участием органов, осуществляющих публичные полномочия, если предмет спора связан с осуществлением предпринимательской деятельности. Автор предлагает закрепить в законе в качестве критерия компетенции соответствующего суда правило о «применимом при разрешении спора праве», что позволит передавать арбитражным судам все дела, вытекающие из предпринимательской деятельности, включая иски к публично-правовым образованиям и требования к органам, осуществляющим публичные полномочия в коммерческой сфере.

According to the author, arbitration and civil procedure legislation needs further reform in terms of delineating the competence of arbitration courts and courts of general jurisdiction. Based on the analysis of current judicial practice, the article shows that the criteria of the subject composition of the parties to the dispute and the nature of the disputed legal relationship do not allow for a proper degree of certainty to attribute cases involving bodies exercising public powers to the powers of various courts, if the subject of the dispute is related to entrepreneurial activity. The author proposes to fix in the law, as a criterion of the competence of the relevant court, the rule on "law applicable in dispute resolution", which will allow all cases arising from entrepreneurial activity to be transferred to arbitration courts, including lawsuits against public legal entities and requirements for bodies exercising public authority in the commercial sphere.
АНАЛИЗ ИНСТРУМЕНТОВ УПРАВЛЕНИЯ ИНВЕСТИЦИОННЫМИ ПРОЦЕССАМИ НА РАЗЛИЧНЫХ УРОВНЯХ ВЛАСТИ
Authors: Шамиль Джавадович Арсланов , Джавад Эмирович Арсланов
Published: December 2024

В статье рассматриваются различные инструменты управления инвестиционными процессами на всех уровнях власти. Проанализирована система инструментов государственного управления инвестиционной деятельностью.
ОСОБЕННОСТИ РАЗВИТИЯ РЕГИОНАЛЬНЫХ ИПОТЕЧНЫХ ФОНДОВ
Authors: Лейла Гаджикурбановна Шахтаманова
Published: December 2024

Цель работы. Настоящее исследование посвящено особенностям развития региональных ипотечных фондов. Изучены преимущественные особенности ипотечных фондов. Методы исследования. Анализ региональных ипотечных фондов. Результаты. Определены основные проблемы развития региональных ипотечных фондов, связанные с необходимостью постоянного совершенствования системы налогообложения в этой сфере. Область применения результатов. Результаты, полученные в ходе исследования, могут представлять интерес для государственных федеральных, региональных и муниципальных органов. Выводы. Региональные ипотечные фонды являются инструментом государственной. Грамотная политика и контроль над деятельностью этого института позволит развивать приоритетные виды экономической деятельности. Препятствием для должного развития региональных ипотечных фондов является несовершенство системы налогообложения.
РОЛЬ СОЦИАЛЬНО-ПСИХОЛОГИЧЕСКОГО КЛИМАТА В УПРАВЛЕНЧЕСКОЙ ДЕЯТЕЛЬНОСТИ ОРГАНИЗАЦИИ
Authors: Марьям Гаджимурадовна Дамаданова
Published: December 2024

На сегодняшний день любое современное общество прогрессирует. Ежесекундно появляются новые открытия, развиваются инновации, доступно многое, но самым непредвидимым является человек и его поведение в различных ситуациях, а именно его интерес и потенциал вызывает социально психологический климат в коллективе, который во многом влияет на продуктивность организации.
ПОТЕНЦИАЛ И ПРОБЛЕМЫ ИСПОЛЬЗОВАНИЯ АЛЬТЕРНАТИВНЫХ ИСТОЧНИКОВ ЭНЕРГИИ В РЕСПУБЛИКЕ ДАГЕСТАН И СКФО
Authors: Наида Абдулаевна Амадзиева , Магомед Гаджимагомедович Дибиров
Published: December 2024

В работе представлен анализ перспектив использования возобновляемых источников энергии в России, Дальнем востоке и Северном Кавказе. Рассмотрено текущее состояние традиционных методов получения энергии в регион. В Дагестане получила реализацию программа комплексной модернизации Дагестанского филиала ПАО «РусГидро», которая предполагает повышение уровня надежности работы оборудования, эффективности использования водных ресурсов.
РОЛЬ НАЦИОНАЛЬНОГО КЛИРИНГОВОГО ЦЕНТРА В РЕГУЛИРОВАНИИ ФИНАНСОВОГО РЫНКА
Authors: Лариса Агамурадовна Гаджимурадова
Published: December 2024

В данной статье рассматривается роль и значение Национального Клирингового Центра, как основного катализатора по размещению государственных денежных средств на финансовых рынках.
МЕЖДУНАРОДНАЯ ВАЛЮТНАЯ СИСТЕМА И ЕЕ ЭЛЕМЕНТЫ
Authors: Гаджимурадова Лариса Агамурадовна
Published: December 2024

В данной статье рассматриваются понятия «валюта» и «международная валютная система», виды валютной системы, а также элементы международной валютной системы.

This article discusses the concepts of “currency” and “international currency system”, types of the currency system, as well as elements of the international currency system.
УПРАВЛЕНИЕ ОРГАНИЗАЦИЯМИ НА ПУТИ К ЦИФРОВОЙ ЭКОНОМИКЕ
Authors: Билалова Узлипат Магомедалиевна , Рамазанова Аида Генакадиевна
Published: December 2024

В статье поднимается ежедневно возрастающая актуальность проблемы обращения к цифровой экономике, определяются основные способы понимания термина цифровой экономики, а также необходимость управления изменениями в организации, возникшими на пути к цифровой экономике.

The article raises the daily increasing urgency to the problem of handling the digital economy, identifies the main ways of understanding so pmin the digital economy and the need to change management in the organization that have arisen on the path to the digital economy.
КОНКУРЕНТОСПОСОБНОСТЬ ОРГАНИЗАЦИИ КАК ФАКТОР ЭФФЕКТИВНОСТИ ИННОВАЦИОННОГО МЕНЕДЖМЕНТА
Authors: Алиева Зарема Алиевна , Гашимова Лейла Гамзабековна
Published: December 2024

В настоящее время существуют такие цели как повышение производительности и прибыльности, завоевание новых рынков и улучшение существующих долей рынка, доступных благодаря инновационной деятельности. Поэтому существует стремление использовать инновационные навыки, приобретать устойчивые способности и повышать свою эффективность.

Nowadays, objectives such as increasing productivity and profitability, gaining new markets and improving existing market shares are reached through innovation activities. Therefore, companies exert themselves to develop innovative skills, gain sustainable abilities and upgrade their performances.
СИСТЕМА УПРАВЛЕНИЯ ПЕРСОНАЛОМ НА ПРЕДПРИЯТИИ
Authors: Генжеева Атикат Яхьяевна , Рамазанова Аида Генакадиевна
Published: December 2024

Данная статья исследует теоретические аспекты управление персоналом, а также посвящена особенностям, а также современным принципам и методам управления персоналом на предприятии. Также отмечается необходимость его совершенствования, что требует поиска новых форм и методов повышения эффективности управления персоналом.

This article explores the theoretical aspects of personnel management, and is also devoted to the features, as well as modern principles and methods of personnel management in the enterprise. The need to improve it is also noted, which requires the search for new forms and methods to increase the effectiveness of personnel management.
ОРИЕНТАЦИЯ НА ЦЕЛЕВОЕ ИСПОЛЬЗОВАНИЕ БЮДЖЕТНЫХ СРЕДСТВ - ОСНОВА ДЕЯТЕЛЬНОСТИ КОНТРОЛИРУЮЩИХ ФИНАНСОВЫХ ОРГАНОВ
Authors: Шахбанова Айна Мамедовна , Гаджимурадова Лариса Агамурадовна
Published: December 2024

В статье рассматриваются примеры претензий контролирующих органов по поводу нецелевого использования субсидии. Авторы анализируют порядок проведения аудиторских проверок нецелевого использования бюджетных средств.

The article examines examples of claims of regulatory authorities regarding the misuse of subsidies. The authors analyze the procedure for auditing the misuse of budget funds.
GROLIGFF – GROMOS force field compatible parameters for Heteromolecules
Authors: MALDE Alpesh
Published: December 2024

A web-server to generate GROMOS (force field)-compatible parameters for large organic drug-like molecules and complex natural products is presented. The web-server GROLIGFF (https:// groligff.net) provides force field topology and parameters that can be used to perform Molecular Dynamics (MD) simulations, Linear Interaction Energy (LIE) calculations and Alchemical Free Energy (FE) calculations. The force field description is generated using a rule-based method combining the GROMOS 54A7 biomolecular force field for bonded and van der Waals parameters with a Bond Charge Increment protocol for partial atomic charges. The output parameters can be used with GROMACS and GROMOS programs with a recommended single range 1.4 nm cut-off for non-bonded interactions.
Designing single polymer chain nanoparticles to mimic biomolecular hydration frustration
Authors: Jin Tianyi , Coley Connor , Alexander-Katz Alfredo
Published: December 2024

Native folded proteins rely on sculpting the local chemical environment of their active or binding sites, as well as their shapes. In particular, proteins exhibit a phenomenon known as “hydration frustration”, i.e. the ability to control the dehydration of hydrophilic and the hydration of hydrophobic residues, respectively, to amplify their chemical or binding activity. Here, we uncover that single polymer chain nanoparticles formed by random heteropolymers composed of three or more components can display similar levels of hydration frustration. We categorize these nanoparticles into three types: i) fully-frustrated globules, where both types of residues display frustrated states, ii) semi-frustrated, with either hydrophobic or hydrophilic residues in a frustrated state, and iii) core-shell nonfrustrated globules. Based on our results, we propose a series of physicochemical rules that determine the state of these nanoparticles. The rules have been tested in both atomistic and simplified Monte Carlo models of single polymer chain nanoparticles with different backbones and residues to show their generality. Our work provides critical insights into the design of single chain nanoparticles, an emerging polymer modality that achieves the ease and cost of fabrication of polymeric material with the functionality of biological proteins.
The Institute of Joint Commission of a Crime in the Doctrine of Russian Pre-Revolutionary Criminal Law
Authors:   Irkutsk State University, Georgievskii E.V.
Published: December 2024

The book is dedicated to the genesis and formation of the institution of joint commission of a crime in domestic pre-revolutionary criminal law. Numerous points of view of Russian criminologists on the legal nature of joint commission of a crime, its types and forms, participants and persons involved in the commission of a crime are analyzed. It is intended for teachers, postgraduate students, students of law schools and faculties, as well as all those interested in the history of criminal law.
Emergência médica
Authors: Paciello Igor Duarte Pinto , Dawes Tathianna Prado , Henriques Maíra Soares
Published: December 2024

No Brasil, uma parcela importante da população tem algum tipo de perda auditiva. No entanto, mesmo na área da saúde pública, ainda há barreiras de comunicação no cenário do atendimento médico à população surda. Dentro do contexto do atendimento ao paciente grave ou com risco de morte, não é permissível este impasse comunicacional. Portanto, este trabalho visou coletar e divulgar sinais-termos essenciais para entendimento eficaz entre profissional de saúde e paciente surdo. Com o apoio do projeto de extensão Libras, Linguística e Divulgação da Universidade Federal Fluminense, foram gravados 80 sinais referentes a 57 termos e disponibilizados para consulta na Plataforma Libras Acadêmica UFF, alimentada pelo mesmo projeto. Foi priorizada a gravação dos sinais utilizados com maior abrangência no país. Ainda assim, constatou-se a falta de sinais que representem muitos outros termos comumente empregados nos serviços de emergências, fazendo-se mais necessário o envolvimento da saúde com a comunidade surda.
Phenotypic screening of genes and compounds modifying lipotoxicity in Saccharomyces cerevisiae
Authors:   , Palfreyman Helen
Published: December 2024

Lipotoxicity is where lipids accumulate in non-adipose tissues and cause apoptosis or necrosis that can lead to diseases such as obesity, diabetes, and non-alcohol fatty liver disease. One in 3 adults in Aotearoa are considered obese and rates of these diseases are predicted to increase, which will put extra pressure on an already struggling healthcare system. It is thus paramount to identify a compound that prevents lipotoxicity.

In chapter 2, I screened 3,300 compounds for their efficacy to suppress lipotoxicity in a lipotoxic yeast model (dga1∆lro1∆) that lacks the DGAT enzymes to tolerate the addition of the fatty acid palmitoleate. I identified 18 compounds that increased the amount of palmitoleate (PO) required for lipotoxicity. Of these 18 compounds, six increased lipid droplet production in dga1∆lro1∆ cells that otherwise produce only one lipid droplet per cell. To further understand the impacts of four compounds (pregnenolone, hexestrol, estradiol and NBI-27914) on lipid metabolism, levels of neutral lipids and phospholipids were monitored using thin-layer chromatography, albeit no significant changes were detected using this methodology. Abundance of proteins involved in various aspects of lipid metabolism was measured using fluorescent microscopy analysis of GFP-tagged proteins, which pointed to the potential importance of the sphingolipid pathway in reducing lipotoxic stress.

In chapter 3, I aimed to find a compound that mimicked the deletion of the SLC1 acyltransferase that previously rescued dga1∆lro1∆ from lipotoxicity, and to characterize the lipid changes seen with slc1Δ. Since slc1∆ale1∆ is synthetic lethal, I predict that a compound toxic to ale1∆ may be an inhibitor of SLC1. Out of the 3,300 compounds screened in chapter 3, nine compounds caused inviability in ale1∆. Four of these nine compounds were further investigated via protein abundance and thin-layer chromatography, which suggested upregulation of sphingolipid synthesis and downregulation of neutral lipid and phospholipid synthesis pathways.

In summary, both chapters implicated the sphingolipid pathway in rescuing dga1Δlro1Δ from lipotoxicity. Compounds that rescued dga1Δlro1Δ seemingly activated the sphingolipid pathway, while slc1Δ seemingly restored sphingolipid synthesis.
French Feminists and Anglo-Irish Modernist: Cixous, Kristeva, Beckett and Joyce
Authors: Birkett Jennifer
Published: December 2024

This essay discusses the importance ascribed to the work of Samuel Beckett and James Joyce by two major French feminists: the philosopher and psychoanaJyst Julia Kristeva and the creative writer and philosopher Helene Cixous. An introductory section gives a short account of the controversy in English feminist academia over the importance attributed to the founding fathers of modernism, which does not appear to have arisen in the French feminist tradition. In Joyce and Beckett, Cixous and Kristeva have acknowledged imaginative models that developed their understanding of the socio-political structures that operate through the family and through language, through deep processes of repression, lo construct individual subjects, male or femaJe. These writers helped shape their perception of the extent to which the Law of the Father is the organising structure of society and its language. And most of all, they have stimulated reflection on the possibility of a language in which to think and talk differently about such things, with the intention of changing them: a language that might subvert patriarchaJ discourse.
Richard Mulcaster's Allegory: A Humanist View of Language and State
Authors: O'Neill Maria
Published: December 2024

Richard Mulcaster's extended allegory which recounts the development of English spelling in terms of the evolution towards the perfect state is evidence of the close identification between state and language that was prevalent in humanist circles in the late sixteenth century. It demonstrates that his originality lay not in innovative ideas but rather in the manner in which he applied to linguistic questions, concepts and precepts from the political field. Drawing on the writings of Sir Thomas Elyot and Thomas Starkey, Mulcaster develops the metaphor not only to justify his moderate approach to a spelling based on tradition and usage but also to condemn the attempts of the phonemic ref0rmers to implant a system based on sound. Finally, the allegory reveals Mulcaster to be more an advocate of a limited monarchy than his other writings would suggest.
The Role of the Event Structure Metaphot and of Image-Schematic Structure in Metaphors for Happiness and Sadness
Authors: Peña Cervel María Sandra
Published: December 2024

Taking as bases the well-known idea that in Cognitive Semantics metaphor, a conceptual rather than a linguistic phenomenon, is considered to be a series of conceptual mappings from a source to a target domain ( cfr. Johnson Lakoll and Turner) and such image-schemata (cfr. Johnson and Lakort) as the container and the path ones, which consist of some structural elements and a basic logic, I analyze some metaphors for emotions, particularly those which express happiness and sadness, two concepts provided with opposite axiological values. Antonio Barcelona studied the same topic a decade ago. My analysis shares some of his ideas, but it differs from his in several points. This article will deal with metaphors based on the container andver ticality schemas, as well as with other complementary metaphors in order to finish by conunenting on the force schema, as postulated by Johnson, and drawing some conclusions regarding the container image-schema.
The Applicability of Linguistic Politeness Studies to Translation: A Case Study
Authors: Rosa Lorés Sanz
Published: December 2024

The present paper picks up on some aspects of a complex attempt to approach politeness studies from a new angle: translation. The most relevant approaches to the study of politeness agree on its two-sided character, which entails, on the one hand, linguistic meaning and, on the other, social meaning. This twofold concept of politeness determines the close relationship between its linguistic expression and the cultural context within which such expression is used. The cultural-relativistic stand that this assumption implies in some ways contradicts or, at least, partly questions, the universal character ascribed to linguistic politeness by one of the seminal - theories in the field: the framework of Politeness theory devised by Penelope Brown and Stephen Levinson in their book Politeness: Some Universals in Language Usage (1978, 1987). In my view, politeness theory and the discussion about what is universal and what is culturally-determined in politeness can benefit from contrastive studies in the field of translation, and translation can also profit from insights into the study of linguistic politeness, as it is my intention to illustrate here with Cat on a Hot Tin Roof and La gata sobre el tejado de zinc caliente as corpora.
Beyond Coding and Control: Leakage, Categorization and Blocking in the Definition of the English Subject
Authors: Javier Martín Arista
Published: December 2024

This paper offers a non-intuitive definition of the English subject by discussing Keenan's coding and control properties and by contending that leakage, blocking properties (co-referentiality, omission of the relative and question target) and categorization must also be taken into account in the definition of this grammatical function. The consideration of leakage and blocking properties allows for a cross-theoretical approach to this syntactic phenomenon that may modify Keenan's hierarchy of subject properties and the hierarchy of syntactic functions of Keenan and Comrie.
The Wandering Flâneur, or, Something Lost in Translation
Authors: Brooker Peter
Published: December 2024

The flaneur and flanerie have become a standard trope in accounts of an emergent modernity and the experience especially of the modern city. More recently, the historical figure of nineteenth-century Paris has been reexamined in readings of the gendered formations of modernism and further reconfigured in accounts of more contemporary, postrnodem forms of urban experience. The Parisian stroller or window-shopper identified by Charles Baudelaire and Walter Benjamin as a new social type and the model of the artist reappears as the mall rat or TV viewer slaloming across channels. This essay argues that, productive as these later discourses often are, critics responding in particular to the "deconstructive turn" are in danger of losing sight both of the historical and spatial specificity of the later postrnodern moment. The flaneur becomes a sight without a referent, an unwitting or romanticised projection of the disengaged textualising theorist. The essay therefore calls for a renewed historical awareness which will not only confirm the situated and short-lived role of the fliineur and significantly different attitude of the female flaneuse in the modernist city, but help to ground the fertile ideas of the nomadic postrnodern intellectual.