bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Cardiovascular Risk Factors and 10-Years Risk for Coronary
Heart Disease in the United Arab Emirates
Authors: Shehab Abdulla , Bakir Sherif , Sabbour Hani , Elnour Asim A. , Mahmeed Wael Al , Salam Amar M. , Kholy Doaa El
Published: April 2022

Background:

In the United Arab Emirates (UAE), cardiovascular diseases (CVDs) are
the leading cause of mortality, and the incidence of premature coronary heart diseases (CHDs) is
about 10-15 years earlier than that in people of western countries.

Aim:

The current cross-sectional study aims to describe the prevalence of CVD risk factors and estimate
the 10-years risk for CHDs in the population of Abu Dhabi, UAE.

Objective:

The main objective was to report the 10-years risk for CHD in a sample of the UAE
population.

Methods:

We have analyzed the dataset from the Abu Dhabi Screening Program for Cardiovascular
Risk Markers (AD-SALAMA), a population-based cross-sectional survey conducted between
2009 and 2015 (a sample of 1002, 20 to 79 years old without CVDs or diabetes).

Results:

18.0% of our sample have had hypertension (HTN), 26.3% were current smokers, 33%
have had total cholesterol ≥200 mg/dL, 55.0% have had non-high-density lipoprotein (non-HDL)
levels ≥130 mg/dL, 33.1% have had low-density lipoprotein cholesterol (LDL-C) levels ≥130
mg/dL, calculated by β-quantification as 112.3 ± 47.1 mg/dL. 66.8% were overweight or obese,
and 46.2% had a sedentary lifestyle. Nearly 85% of our sample has had one or more major cardiovascular
risk factors.
The estimated 10-year risk of cardiovascular disease according to different risk assessment
tools was as follows: 7.1% according to the national cholesterol education program Framingham
risk score (FRAM-ATP), 2.9% according to Pooled Cohort Risk Assessment Equation
(PCRAE) , 1.4% according to the National Cholesterol Education Program Adult Treatment
Panel III (NCEP ATP III), and 1.1% according to Reynolds Risk Score. Despite the fact that
our sample population have had exhibited major risk factors, the above-mentioned international
scoring systems underestimate the 10-year risk of cardiovascular diseases, given the
high prevalence at younger ages.

Conclusion:

The proportion of modifiable risk factors has been found to be high in the UAE population,
and the majority of them have had one or more risk factors with a higher 10-years risk for
CHDs.
Elucidating the Focal Immunomodulatory Clues Influencing Mesenchymal Stem Cells in the Milieu of Intervertebral Disc Degeneration
Authors: Hechavarria Maite Esquijarosa , Richard Seidu A.
Published: April 2022

The intervertebral discs (IVDs) are a relatively mobile joint that interconnects vertebrae of the spine. Intervertebral disc degeneration (IVDD) is one of the leading causes of low back pain, which is most often related to patient morbidity as well as high medical costs. Patients with chronic IVDD often need surgery, that may sometimes lead to biomechanical complications as well as augmented degeneration of the adjacent segments. Moreover, treatment modalities like rigid intervertebral fusion, dynamic instrumentation, as well as other surgical interventions are still controversial. Mesenchymal stem cells (MSCs) have exhibited to have immunomodulatory functions and the ability to differentiate into cartilage, making these cells possibly an epitome for IVD regeneration. Transplanted MSCs were able to repair IVDD back to the normal disc milieu via the activation of the generation of extracellular matrix (ECM) proteins such as aggrecan, proteoglycans and collagen types I and II. IVD milieu clue like, periostin, cluster of differentiation, tumor necrosis factor alpha, interleukins, chemokines, transforming growth factor beta, reactive oxygen species, toll-like receptors, tyrosine protein kinase receptor and disialoganglioside, exosomes are capable of influencing the MSCs during treatment of IVDD. ECM microenvironment clues above have potentials as biomarkers as well as accurate molecular targets for therapeutic intervention in IVDD.
Recent Patents on Plant-Derived Nanoparticles and their Potential
Application Towards Various Cancer Therapeutics
Authors: Santhosh S.B. , Shanmugarama Santny , Ramesh Nimma , Tharik A. Mohamed Sheik , Basamshetty Veera Vijaya
Published: April 2022

Background:

Nanotechnology plays a vital role in the field of medicine. Especially various nanoparticles such as silver, gold, platinum are involved in the treatment of different types of cancer. The effective nanoparticles were synthesized using techniques like chemical, physical, electrochemical and biological methods. In order to overcome the limitations existing in the synthesis of nanoparticles, researchers turned their attention toward the biological single step nanoparticle synthesis method by using plant and plant products.

Objective:

The objective of this study is to overcome the side effects encountered in the existing anti-cancer agents like nonspecificity and fast excretion, and plant-derived nanoparticles that are eco-friendly, cost-effective and biologically active could serve as a promising alternative.

Conclusion:

From the thorough literature review and recent patents, it is understood that the plant-derived nanoparticles exhibited an excellent anti-proliferation anti-tumor activity towards different types of cancers without affecting the normal cells. Especially, the traditional chemotherapeutic drugs obtained from the plant source incorporated with the nanoparticles show remarkable results against anti cancer studies. The present review focused on some of the existing herbal plant derived nanoparticles, formulations and their potential application in cancer therapeutics.
Celastrus orbiculatus Extract Inhibits the Invasion and Migration of Human Gastric
Cancer Cells in the Hypoxia Microenvironment
Authors: Feng Guangqing , Chu Zewen , Wang Haibo , Liu Yanqing , Zhu Fangshi
Published: April 2022

Background:

Gastric cancer is a common global disease. So far, the best choice for diagnosis and treatment
of gastric cancer includes surgical resection, chemotherapy, and other targeted drug therapies; however, the overall
survival rate of patients with gastric cancer is still very low. The hypoxic microenvironment facilitates tumor cells to
develop tolerance to chemotherapy and radiotherapy and promotes the early invasion and metastasis of various tumors.
Celastrus Orbiculatus extract (COE) has shown inhibitory activities against a variety of tumor cells. In this study, we
found that COE could inhibit the invasion and migration of gastric cancer cells by inhibiting epithelial-mesenchymal
transformation (EMT) in the hypoxia microenvironment.

Methods:

CoCl2 was first diluted to various concentrations and then used to treat MKN28 and AGS cells. The MTT
(thiazolyl blue) assay was used to evaluate cell proliferation. The transwell assay was used to measure the invasion and
migration abilities of the cells. Wound healing assays were used to detect the healing ability of the cells. Western blotting
was used to assess the effects of COE on the expression of EMT and matrix metalloproteinase (MMP) signaling
pathway-related proteins.

Results:

We found that gastric cancer cells showed stronger proliferation, invasion, and metastasis in the hypoxia
microenvironment. COE inhibited the migration and invasion of AGS and MKN28 cells in both hypoxic and normoxic
environments. Additionally, COE decreased the expression of EMT and MMP signaling pathway-related proteins in
gastric cancer cells.

Conclusion:

Therefore, it can be concluded that COE suppresses the migration and invasion of gastric cancer cells by
inhibiting EMT and MMP in the hypoxia microenvironment.
Recent Trends in Nano-Particulate Carriers for the Diagnosis and Treatment
of Alzheimer’s Disease
Authors: Yadav Awesh K. , Mazahir Farhan
Published: April 2022

Background:

Alzheimer's disease (AD) is characterized by the presence of aggregated
amyloid fibers, neurodegeneration, and loss of memory. Although "Food and Drug Administration"
(FDA) approved drugs are available to treat AD, drugs that target AD have limited access to the brain
and cause peripheral side effects. These peripheral side effects are the results of exposure of peripheral
organs to the drugs. The blood-brain barrier (BBB) is a very sophisticated biological barrier that allows
the selective permeation of various molecules or substances. This selective permeation by the
BBB is beneficial and protects the brain from unwanted and harmful substances. However, this kind of
selective permeation hinders the access of therapeutic molecules to the brain. Thus, a peculiar drug delivery
system (nanocarriers) is required.

Objective:

Due to selective permeation of the “blood-brain barrier,” nanoparticulate carriers may provide
special services to deliver the drug molecules across the BBB. This review article is an attempt to
present the role of different nanocarriers in the diagnosis and treatment of Alzheimer's disease.

Method:

Peer-reviewed and appropriate published articles were collected for the relevant information.

Result:

Nanoparticles not only traverse the blood-brain barrier but may also play roles in the detection
of amyloid β, diagnosis, and drug delivery.

Conclusion:

Based on published literature, it could be concluded that nano-particulate carriers may
traverse the blood-brain barrier via the transcellular pathway, receptor-mediated endocytosis,
transcytosis, and may enhance the bioavailability of drugs to the brain. Hence, peripheral side effects
could be avoided.
Quality of Life in Menopausal Women with Dental Restorations and Implants
Authors: Stefos Spyridon , Kourtis Stefanos , Vrekoussis Thomas , Augoulea Areti , Kalantaridou Sophia
Published: April 2022

Aim:

This multicenter study examined the relationship, possible interactions, and intermittent effects that dental implants and prostheses can have on menopausal women’s quality of life as well as provided information regarding the possible side effects of therapeutic regimens on menopause and osteoporosis or osteopenia.

Materials and Methods:

Questionnaires consisted of selected quality of life questions based on specific and additional medical and dental (mainly prosthodontic) questions, which were administered to 100 Greek menopausal/post-menopausal women (Age: Mean Value=63,62 years old) with osteopenia or with or without osteoporosis, with dental implants and implant restorations, or conventional prosthetic restorations visiting two University Hospitals. Menopausal/post-menopausal status was judged on the basis of either secondary, definitive amenorrhoea or based on follicular stimulation hormone ​​(FSH) values, estradiol, and clinical risk factors.

Results:

Participants had a statistically significantly better “functional” and “psychological” feeling after prosthodontic rehabilitation with and without implants. Three out of four reported that their dentist informed them of the possible implant problems that might arise from osteoporosis and its treatment (medications). Moreover, osteopenia was found to be associated with a very lower problem percentage. The bisphosphonate treatment had the highest rate (80%) of reported implant problems than non-bisphosphonate treatment (30%). The hormone replacement therapy (HRT) for menopause was reported to be more associated with problems in implant placement (19%) than in those without treatment (27.3%).

Conclusion:

The questionnaires revealed a significant improvement concerning women’s life quality and well-documented information about the problems their dental implants and restorations may cause in association with menopause and/or osteoporosis.
LITTLE DOCTOR VIRTUAL TRAINING WITH SNOWBALL TECHNIQUE IN PANDEMIC COVID-19 ERA IN ELEMENTARY SCHOOL MALANG
Authors:   Department of Community Dental and Oral Health and Prevention, Faculty of Dentistry, Universitas Brawijaya, Balbeid Merlya , Pratamawari Dyah Nawang Palupi ,   Department of Community Dental and Oral Health and Prevention, Faculty of Dentistry, Universitas Brawijaya, Listari Khusnul Munika
Published: April 2022

Strategies that can be taken to achieve caries-free Indonesia 2030 include is increasing promotive and preventive efforts for dental and oral health services. Even in this Pandemic Covid 19 the delivery of counseling or promotive materials is not done face-to-face, because it avoids the risk of local transmission Covid-19 virus. This study aims to increase the knowledge of dental and oral health of elementary school students during the pandemic. The method was through audiovisual media facilitated with online meeting zoom and e-Book. This activity was carried out using the snow-ball technique, 6 elementary schools doing this activity. The activity started with dental training by the FKGUB team through the media zoom with room separation in 6 breakout rooms, so a total of 42 participants attended. After that were held for Little Doctors activities to educate 5 friends in their elementary schools, so there was 150 participants. In the pre-test results, as many as 18 students scored below 50 and as many as 10 students scored above 50. In the post-test results, 24 students got scores above 50 and 1 student got a score of 20. There is a difference knowledge level oral health of students by little doctor with online education in pandemic Covid-19 Era in elementary school Malang.
POP-UP BOX EDUCATIONAL APPLICATION “SI DUMBO” MAKES VOICE IN IMPROVING DENTAL AND ORAL HEALTH BEHAVIOR FOR CHILDREN AGED 6-8 YEARS IN A PANDEMIC PERIOD
Authors:   IKGMP Department, Faculty of Dentistry, Universitas Brawijaya, Malang, Widodorini Trining , Hernani Yully Endang ,   IKGMP Department, Faculty of Dentistry, Universitas Brawijaya, Malang, Swastirani Astika ,   Department of Oral Medicine, Faculty of Dentistry, Universitas Brawijaya, Malang, Mushfira Naadhira , Wardhani Nabilah Kusuma , Rubiyanti Safira Yusinta ,   Professional Dentistry Study Program, Faculty of Dentistry, Universitas Brawijaya, Malang
Published: April 2022

Limitations in conducting online learning due to the COVID-19 pandemic become the background for researchers to create an online version of a pop-up educational storybook that spoke about dental and oral health information. The target of this research is children aged 6-8 years because it is the right age to train motor skills, observe and discover new things and the parents of these children as companions in the development of knowledge and behaviour in maintaining oral health. Therefore, it is very important to provide dental and oral health education as well as familiarize children with brushing teeth at the right time in the right way and to educate parents so that they can guide children regarding behaviour in maintaining dental and oral health. Objective: To increase literacy interest in children from an early age, combining digital technology with conventional books to increase children's and parents' knowledge about dental and oral health as measured through pre-test and post-test questionnaires. Methods: The research used a pre-experimental research method in the form of a one group pre-test-post-test experiment. The sample was selected by the total technique sampling. The independent variable studied was dental and oral health counseling using the Voiced Dumbo Pop Up Box, while the dependent variable in this study was the knowledge of children and parents about oral health as measured by pre-test and post-test questionnaires. Results: Based on the results of the paired T test as a whole, the p value = 0.035 which stated that there was a difference in the total pre and total scores of the post test. Question accuracy which assesses the percentage of pre-test and post-test of children aged 6-8 shows that 98% of the 30 students have answered the post-test accurately and increased (pre-test 86%). Conclusion: The voice of Dumbo's Pop-up Box counseling media is able to significantly increase the knowledge of dental and oral health in students aged 6-8 years at SDN Sukun 3, Malang City.
The Functional Properties of Rabbit Skin Gelatin Compared to Commercial Gelatin and Its Application in Jelly Candy
Authors: Nurwantoro Nurwantoro , Hintono Antonius , Legowo Anang Mohammad , Mulyani Sri , Quna Tisqa Rizky , Sutaryo Sutaryo
Published: April 2022

Rabbit skin can be utilized as an ingredient in gelatin making. Gelatin can be used in jelly candy. The study aims to compare the functional properties of rabbit skin gelatin and commercial gelatin in gel strength, viscosity, and ash content and to determine the different test and hedonic test of jelly candy. This study used the t-test with 2 treatments and 8 replications. The rabbit skin gelatin was prepared using hydrochloric acid solution. The commercial gelatin is gelatin from cowhide (Gelita bronze gelatin). The results showed that P1 (rabbit skin gelatin) and P2 (commercial gelatin) were not different on gel strength, however, there was a difference on viscosity and ash content. The difference test on jelly candy state that there was a significant difference between rabbit skin gelatin jelly candy and commercial gelatin jelly candy. The hedonic test on jelly candy gave no difference on texture, flavor, taste, and overall, except there was a difference on color. The color of jelly candy with rabbit skin gelatin is a cloudy white, while jelly candy with commercial gelatin is a clear white. Both jelly candies can be distinguished and accepted by the panelist.
Potential of Pumpkin Flour as a Stabilizer in Reduced-Fat Mayonnaise
Authors: Nidhal Hemas Azizila , Evanuarini Herly , Thohari Imam
Published: April 2022

Pumpkin is a local plant that contains antioxidants such as polyphenols and carotenoids. Pumpkin contains pectin which can function as a stabilizer. Full-fat mayonnaise is a semi-solid emulsion product that has a total fat content of 70-80%, while reduced-fat mayonnaise has a fat content of 50-60%. Pumpkin flour can be applied to reduced-fat mayonnaise in terms of physicochemical quality. This research was conducted using a laboratory experimental method and a completely randomized design. The physicochemical qualities of reduced-fat mayonnaise include fiber content, fat content, viscosity, and antioxidant activity. The results of added pumpkin flour have a highly significant effect (P<0.01) on fiber content, fat content, viscosity, and antioxidant activity. The physicochemical qualities of reduced-fat mayonnaise with pumpkin flour are as follows 0.90% fiber content, 50.57% fat content, 4443 cP viscosity, and 21.03% antioxidant activity, respectively. It can be conclude that the use of 6% yellow pumpkin flour was the best treatment for reduced-fat mayonnaise. The most types of fatty acids in the best treatment were palmitic, oleic, and linoleic acids.
Источник ультрахолодных нейтронов на основе сверхтекучего гелия для реактора ПИК
Authors: Серебров А.П. , Лямкин В.А. , Фомин А.К. , Онегин М.С.
Published: April 2022

The PIK reactor at NRC "Kurchatov Institute" - PNPI is going to be equipped with a high-flux Ultra Cold Neutron (UCN) source for fundamental physics researches. The UCN source will use superfluid helium, which will make possible to achieve the density of UCN 2.2·10^3 cm-3, that has not yet been achieved anywhere in the world. The UCN source will be installed on the GEK-4 channel, which will make possible to obtain a low value of heat influx to cryogenic vessels from reactor radiation. The heat removal from the UCN source vessel will be implemented by using a heat exchanger. The calculated UCN density in the EDM spectrometer chamber at the PIK is going to be 200 cm-3, which is 20 times higher than the existing UCN densities in the world. For a new UCN source based on superfluid helium, an extensive research program has been developed in field of the physics of fundamental interactions, including the search for a nonzero neutron EDM, precision measurement of the neutron lifetime, and search for mirror dark matter.
One Hundred Years of Hypertension Research: Topic Modeling Study
Authors: Abba Mustapha , Nduka Chidozie , Anjorin Seun , Mohamed Shukri , Agogo Emmanuel , Uthman Olalekan
Published: April 2022

Background

Due to scientific and technical advancements in the field, published hypertension research has developed substantially during the last decade. Given the amount of scientific material published in this field, identifying the relevant information is difficult. We used topic modeling, which is a strong approach for extracting useful information from enormous amounts of unstructured text.

Objective

This study aims to use a machine learning algorithm to uncover hidden topics and subtopics from 100 years of peer-reviewed hypertension publications and identify temporal trends.

Methods

The titles and abstracts of hypertension papers indexed in PubMed were examined. We used the latent Dirichlet allocation model to select 20 primary subjects and then ran a trend analysis to see how popular they were over time.

Results

We gathered 581,750 hypertension-related research articles from 1900 to 2018 and divided them into 20 topics. These topics were broadly categorized as preclinical, epidemiology, complications, and therapy studies. Topic 2 (evidence review) and topic 19 (major cardiovascular events) are the key (hot topics). Most of the cardiopulmonary disease subtopics show little variation over time, and only make a small contribution in terms of proportions. The majority of the articles (414,206/581,750; 71.2%) had a negative valency, followed by positive (119, 841/581,750; 20.6%) and neutral valency (47,704/581,750; 8.2%). Between 1980 and 2000, negative sentiment articles fell somewhat, while positive and neutral sentiment articles climbed substantially.

Conclusions

The number of publications has been increasing exponentially over the period. Most of the uncovered topics can be grouped into four categories (ie, preclinical, epidemiology, complications, and treatment-related studies).
Effect of an Active Video Game Intervention Combined With Multicomponent Exercise for Cardiorespiratory Fitness in Children With Overweight and Obesity: Randomized Controlled Trial
Authors: Comeras-Chueca Cristina , Villalba-Heredia Lorena , Perez-Lasierra Jose Luis , Lozano-Berges Gabriel , Matute-Llorente Angel , Vicente-Rodriguez German , Casajus Jose Antonio , Gonzalez-Aguero Alex
Published: April 2022

Background

Childhood overweight and obesity have become major global health problems and are negatively related with the cardiorespiratory fitness (CRF) level in school children and adolescents. Exercise, specifically multicomponent training, is effective for CRF improvement, but the main challenge is to ensure adherence to exercise in children with overweight and obesity. Therefore, new ways of exercising that are more attractive and motivational for this population are needed and playing or training with active video games (AVGs) has been proposed as an effective alternative because they require full-body movement and therefore increase energy expenditure.

Objective

The main aim of this study was to investigate the effects of an AVG intervention combined with multicomponent training on CRF at maximal and submaximal intensities in children with overweight or obesity.

Methods

We recruited 28 children (13 girls and 15 boys) aged 9 to 11 years with overweight or obesity from medical centers and divided them into 2 groups, an intervention group (n=20) that participated in a 5-month supervised AVG exercise program combined with multicomponent exercise, and a control group (n=8) that continued daily activities without modification. A maximal stress test to measure CRF using a walking-graded protocol with respiratory gas exchange was performed by the participants.

Results

The AVG group showed a significant decrease in heart rate and oxygen uptake for the same intensities in the submaximal stages of the maximal treadmill test, as well as a lower oxygen uptake percentage according to the individual maximal oxygen uptake, whereas the control group did not show overall changes. No change in the peak oxygen uptake (VO2peak) was found.

Conclusions

A 5-month AVG intervention combined with multicomponent exercise had positive effects on CRF at submaximal intensity, showing a lower heart rate and oxygen uptake at the same intensities and displaying a lower oxygen uptake percentage according to the individual (VO2peak). Greater benefits were found in children with the highest fat percentage.

Trial Registration

ClinicalTrials.gov NCT04418713; https://clinicaltrials.gov/show/NCT04418713
Acceptance of an Internet-Based Team Development Tool Aimed at Improving Work-Related Well-being in Nurses: Cross-sectional Study (Preprint)
Authors: Broetje Sylvia , Bauer Georg F , Jenny Gregor J
Published: April 2022

BACKGROUND

Workplace health interventions can produce beneficial health- and business-related outcomes. However, such interventions have traditionally focused on lifestyle behaviors of individuals, mostly not considering the role of working conditions. The wecoach intervention is an internet-based tool that combines both a digital and a participatory team development approach aimed at addressing critical job demands and resources as key aspects of health-promoting working conditions. Nursing staff are particularly affected by challenging working conditions and could potentially benefit greatly. Understanding the acceptance of novel workplace health promotion approaches is a critical precursor to their successful implementation and use.

OBJECTIVE

This study aims to examine the factors influencing the acceptance of a digitally supported team development tool among nurse managers.

METHODS

A sample of 32 nurse managers from 3 German-speaking countries tested wecoach and completed our online questionnaire. Hypotheses were based on the unified theory of acceptance and use of technology (UTAUT) and the organizational health development (OHD) model and were tested using multiple regression analyses.

RESULTS

Our analyses found that merely capacities on the team level (CapTeam) significantly contributed to the acceptance of wecoach, although only after the other variables were excluded in the stepwise multiple regression analysis. The UTAUT predictors were unable to add significant variance explanation beyond that, and their inclusion masked the contribution of CapTeam.

CONCLUSIONS

For the acceptance of a digitally supported participatory tool, the fit with the team, its culture, and its motivation are of critical importance, while aspects proposed by traditional acceptance models, such as the UTAUT, may not be applicable.
Appeal of Editor-in-Chief
Authors: Pankiv V.I.
Published: April 2022

No abstract
Magnesium deficiency in type 2 diabetes mellitus andits effect on blood glucose control and diabetes complications
Authors: Karatas Savas , Hacıoglu Yalcın , Kose Şennur
Published: April 2022

Background. Diabetes has become more often in all over the world, magnesium is an essential element of the body and has lots of vital functions. There has been a trend to investigate magnesium’s effect on type2 diabetes pathogenesis and its complications. Still, more data is needed to reveal magnesium and T2 diabetes mellitus (DM) association, therefore we aimed to investigate how common magnesium deficiency in Turkish T2DM patients, and its effect on diabetes control and diabetes complications. Materials and methods. 296 patients with type 2 DM and 96 healthy controls aged between 18–65 years were enrolled in the study. After exclusion criteria, T2DM patients were divided into 2 groups according to magnesium deficiency, metabolic and physical properties of the groups were compared. Also, hypertension, metabolic syndrome, coronary artery disease, and microalbuminuria were also compared according to magnesium deficiency. Results. Magnesium deficiency was found 35.5% (86/242) in patients with type 2 DM, 4.1% (4/96) in the control group. Magnesium deficiency was more in female patients (64/86, 74.4%), male patients had more normal magnesium levels 89/166, 53.6%) (p<0.01). Hypomagnеsemia patients with T2 DM didn’t show difference in HbA1c (9.0±1.9% vs 8.8±1.6%, p=0.35), and fasting blood glucose levels (197.24±87.25 vs 177.85±57.22 mg/dl, p=0.14). Hypomagnеsemia patients with T2DM had significantly higher hyperlipidemia levels (48.8% (42/86) vs 41.0% (64/156), p=0.04). Metabolic syndrome (89.0% (73/82) vs 83.1% (123/148), p=0.22) and coronary artery syndrome (39.5% (34/86) vs 35.9% (56/156), p=0.85) didn’t differ between groups. Hypertension (81.4% (70/86) vs 67.9 (60/156), p=0.04) and microalbuminuria (66.7% (38/57) vs 43.7 (58/119), p=0.03) were significantly higher in the hypomagnеsemia T2DM group. Conclusions. Magnesium deficiency is not rare in T2DM, however, this deficiency didn’t impact blood glucose control at a significant level in current study, on the other hand, hypertension, microalbuminuria, and hyperlipidemia components of diabetes have been shown to increase with magnesium deficiency.
Hypercortisolism on the background of recovery of COVID-19 (сase report)
Authors: Kravchenko V. , Rakov O. , Slipachuk L.V.
Published: April 2022

Damage to the lung tissue is a predominant complication of the viral disease COVID-19. Recently, there have been complications from other organs, including highly vascularized endocrine glands. Regarding the adrenal glands, there are reports of their damage with a decrease in their function. Сhanging the function of the adrenal glands (AG) in patients with or after COVID-19 is important. A few adrenal autopsy studies in patients have revealed vascular thrombosis, cortical lipid degeneration, ischemic necrosis, parenchymal infarcts, and other lesions leading to a decrease in AG function. The central mechanism of adrenal dysfunction through hemorrhage and necrosis of the pituitary gland is also possible. This paper presents a rare case of the development of hypercortisolism in a young woman after recovering from COVID-19. Based on high ACTH levels (157 and 122pg/ml), a negative nocturnal dexamethasone test, and high 24-hour urinary free (daily) cortisol excretion rates, we tentatively suspected Cushing’s disease. Chromogranin A was within the normal range of 21.35 (reference value <100). Other tests showed an elevated dihydrotestosterone level of 780.6 pg/ml (reference values 24–368 pg/ml). The levels of other anterior pituitary hormones tested were within the normal range. According to clinical guidelines, the drug of choice for the short-term treatment of this disease is steroidogenesis inhibitors— ketoconazole. The effectiveness of such a treatment regimen was previously brought to light by others. In our case, ketoconazole was prescribed at a dose of 400 mg 2 times a day and cabergoline (dostinex) at an initial dose of 1 mg per day. Given the low levels of vitamin D in the blood serum, it was recommended to continue taking vitamin D at a dose of 4000 IU per day. It was recommended to control blood laboratory parameters— serum cortisol, ACTH, AST, ALT, electrolytes, 25(OH)D, blood glucose level after 2 months and decide on further tactics for managing the patient.
Review Paper on Network Data Verification Using Machine Learning Classifiers Based On Reduced Feature Dimensions
Authors: Deshmukh Miss. Maithili , Pund Dr. M. A.
Published: April 2022

Abstract: With the rapid development of network-based applications, new risks arise and additional security mechanisms require additional attention to improve speed and accuracy. Although many new security tools have been developed, the rapid rise of malicious activity is a serious problem and the ever-evolving attacks pose serious threats to network security. Network administrators rely heavily on intrusion detection systems to detect such network intrusion activity. A major approach is machine learning methods for intrusion detection, where we learn models from data to differentiate between abnormal and normal traffic. Although machine learning methods are often used, there are some shortcomings in the in-depth analysis of machine learning algorithms in terms of intrusion detection. In this work, we present a comprehensive analysis of some existing machine learning classifiers with respect to known intrusions into network traffic. Specifically, we analyze classification with different dimensions, that is, feature selection, sensitivity to hyper-parameter selection, and class imbalance problems that are involved in intrusion detection. We evaluate several classifications using the NSL-KDD dataset and summarize their effectiveness using detailed experimental evaluation. Keywords: IDS, Machine Learning, Classification Algorithms, NSL-KDD Dataset, Network Intrusion Detection, Data Mining, Feature Selection, WEKA, Hyperparameters, Hyperparameter Optimization.
RUSSIAN FEDERATION POLICY IN THE FIELD OF RENEWABLE ENERGY: CURRENT STATUS, LEGISLATIVE FRAMEWORK AND DEVELOPMENT PROSPECTS
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Татьяна Васильевна Мартыненко , Вероника Дмитриевна Коноплева ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: April 2022

In this article, the authors provide an analysis of the policy pursued by the Russian state in the field of the use of renewable energy. Over the past decade, green energy has been one of the fastest growing areas in the global energy market. In some countries, alternative energy sources have begun to successfully compete with hydrocarbons. However, when developing a policy in this direction, one should take into account the difficulties and problems that arise for objective reasons. In our opinion, a very balanced, thoughtful and adequate policy is needed, which will allow renewable energy sources to take exactly the place that will not undermine the economic development of the country.
MEASURES TO COUNTER THE PHENOMENON OF MORAL INDIFFERENCE IN CONTEMPORARY CHINA
Authors:   Шанхайский политико-юридический университет, Шанхай, КНР, Чу Дефон
Published: April 2022

The phenomenon of moral indifference, as a lack of "goodness", is manifested in real life as the isolation and loneliness of interpersonal moral relations, and the resulting indifference, indifference, and even mutual exclusion of moral behaviors. and negation. Standing at the starting point of the rapid and profound transformation of contemporary Chinese society, the root causes of moral indifference are "the fragility of interpersonal moral emotions in strangers' society", "the dissolution of the moral beliefs of the planned economy by the market economy", and the "lack of moral reward mechanism". Therefore,in the governance of the phenomenon of moral indifference in contemporary China, firstly, through reforming citizen moral education, we should enhance citizens' subjective good concept, and solve the fragile problem of "moral emotion" between strangers in society; secondly, we should cultivate a good public life ethic, Eliminate the negative impact of the market economy on the disintegration of moral beliefs in the planned economy society; thirdly, establish and improve the moral reward mechanism to promote the formation of a social atmosphere in which everyone respects morality and seeks kindness.
THE ROLE OF THE SUBCULTURE OF FOOTBALL FANS IN THE FORMATION OF EXTREMIST ATTITUDES AMONG YOUNG PEOPLE
Authors:   Южный федеральный университет, Институт социологии и регионоведения, Ростов-на-Дону, Россия, Яна Викторовна Артамонова , Сергей Сергеевич Барсуков ,   Ростовский юридический институт МВД России, Ростов-на-Дону, Россия
Published: April 2022

Due to the fact that youth extremism is currently one of the most dangerous problems of modern Russian society, the authors of the work turn to the subculture of football fans, which influences the formation of extremist sentiments in the youth environment. In this article, the authors of the work relate to the historical aspects of the emergence of the subculture of Russian football fanaticism, characterize fan organizations, consider their subculture, analyze the reasons for the presence of extremist and racist manifestations among fans, propose methods to combat these phenomena, including by organizing competent interaction and joint efforts of law enforcement agencies, football clubs and the fans themselves.
INSTITUTE OF POLYGAMY AND GENDER ASSESSMENT OF THE MODEL OF MARRIAGE BEHAVIOR
Authors:   Институт истории, археологии и этнографии, Дагестанский федеральный исследовательский центр РАН, Махачкала, Россия, Эльвира Махачевна Загирова
Published: April 2022

Within the framework of the study of the Dagestan family and the destructive processes taking place in it, among which the emergence of the institution of polygamy, the key is to establish the attitude of the “first wife” to the decision of his spouse to have a “second wife”. It is hypothesized that a man's decision to have a “second wife” and “second family” is influenced by his status and income level. The results of the author's research show that the overwhelming majority of the surveyed population considers a man to be the head of the family. When assessing the marriage behavior of a spouse, the respondents are ready to take drastic measures when the spouse decides to have a “second wife”. However, most often the first wife is forced to come to terms with the husband's decision to have a “second wife” for a variety of reasons, including material dependence on the spouse, the desire to raise and educate children in a complete family, as well as unwillingness to change the established way of family life.
DEVIANT BEHAVIOR OF YOUNG PEOPLE: SOCIAL FACTORS, ITS DETERMINANTS
Authors:   Кубанский государственный аграрный университет, Краснодар, Россия, Галина Суреновна Чикаева , Виктория Николаевна Власова ,   Ростовский государственный медицинский университет, Ростов-на-Дону, Россия, Владимир Викентьевич Ковров ,   Севастопольский государственный университет, Севастополь, Россия
Published: April 2022

The changes that are taking place in modern social reality make the process of socialization of Russian youth more difficult, which in turn forces young people to find ways of social behavior that are optimal for themselves. Very often, such behavior becomes deviant from the norms existing in society - deviant. The authors of the article draw attention to the fact that the uncertainty of social reality, in addition to traditional deviations, encourages new types of deviations, for example, cyberbullying, virtual fraud, computer, telephone addiction. According to the authors of the work, the emergence of deviant behavior of Russian youth depends on a number of factors of the macrosocial environment: digitalization, informatization, pragmatism, overconsumption, a decrease in the level of spirituality, the lack of generally accepted ideals, the ideology of tolerance. The identified factors contribute to the fact that modern young people tend to try various social practices, not allowing the thought that this may adversely affect themselves and the people around them.
ENSURING TRANSPARENCY AND OPENNESS IN THE ACTIVITIES OF ACTORS OF POLITICAL GOVERNANCE AS A FACTOR IN IMPROVING THE QUALITY OF THE AUTHORITIES
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Андрей Викторович Ляхов
Published: April 2022

The article is devoted to the consideration of topical issues of transparency and openness of the Russian Federation authorities' activity; the analysis of normative-legal dimension of the context of regulation of authorities' openness sphere has been carried out; the peculiarities of comprehension of the power transparency phenomenon as a mechanism for parrying challenges explicated by the double standards expansion in practice of the social and political processes' usage "zones" have been studied.
THE IMPACT OF THE PANDEMIC ON THE SYSTEM OF VENTURE FINANCING OF INNOVATIVE PROJECTS
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Алина Владиславовна Глущенко , Евгений Александрович Довгань ,   Волгодонский филиал Ростовского юридического института МВД России, Волгодонск, Россия, Антонина Викторовна Павлюкова ,   Донской казачий государственный институт пищевых технологий и бизнеса – филиал Московского государственного университета технологий и управления им. К. О. Разумовского (Первый казачий университет), Ростов-на-Дону, Россия
Published: April 2022

The article substantiates the impact of the pandemic on the system of venture financing of innovative projects. Based on the analysis of statistical data, the specificity of venture financing in Russia and in the world has been revealed. It was noted that the new conditions caused by the COVID-19 pandemic had a beneficial effect on the development of venture financing for innovative projects.
OPPORTUNITIES AND THREATS OF DIGITAL (OPEN) BANKING IN THE CONDITIONS OF IMPLEMENTATION OF THE API INTERFACE
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Софья Сергеевна Дукян , Сергей Николаевич Татаркин ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: April 2022

The article discusses technologies in digital banking, the ability to manage your finances, as well as the financial services sector and solutions to reduce financial risks that threaten the safe functioning of the banking system.
Vyacheslav Ivanov’s University File as a Biographical Source
Authors: Sobolev Alexander L.
Published: April 2022

The article presents Vyacheslav Ivanov's student files from the archives of Moscow University, where Ivanov studied for four semesters in 1884 –1886 at the Faculty of History and Philology (but did not complete the full course). Some documents demonstrate the course of student Ivanov’s work at ancient Greek and Latin literature classes, and at the courses he took by historians V. Guerrier and V. Klyuchevsky. Of particular importance are the documents attached to the case about Ivanov's childhood and school years, containing detailed information about the father of the future writer (I. Ivanov's formulary list of 1871). These are the birth and baptismal certificate of Vyach. Ivanov, a certificate of the 1st Moscow Gymnasium with excellent marks in all subjects, a military registration certificate, etc. The student file contains also the decision of the spiritual consistory of 1896 on the annulment of Ivanov’s first marriage with a ban to enter into a new marriage.
Does internal control process and firm characteristics improve firm value? An empirical analysis in the manufacturing sector.
Authors: Janardhanan Anju Kalluvelil , Ramkumar Uma Vakadae
Published: April 2022

The purpose of this research is to investigate the role of enterprise risk management (ERM), Big4 auditors and firm characteristics on firm value. This population study was conducted in the Indian manufacturing sector. Annual panel data for 11 years (2007–2017) was collected from 60 firms on the National Stock Exchange (NSE). Empirical findings prove that there is variation in Tobin’s Q but no difference in return on assets (ROA) and return on equity (ROE) among firms that have implemented ERM and included Big4 audit firms. The study documents that Q was influenced by the implementation of ERM, liquidity, firm age and firm size. Findings reveal that ERM, firm size, leverage, firm age, liquidity and firm complexity impacted ROA. The study outcome also shows ROE was affected by leverage, firm size, liquidity and firm complexity. This study is a valuable addition to the existing studies on the Indian manufacturing sector and has contributed incredible insights to the empirical literature on firm value from the multidimensional outlook of the purchasers, management, and investors. The findings have several implications for investors, managers and researchers.
Gestalt Therapy in Brazil
Authors: CIORNAI SELMA
Published: April 2022

This article gives an overview of the Gestalt therapy movement in Brazil, highlighting its special features and characteristics, through comparison of the author's experiences with Gestalt therapy in Brazil and abroad. Attention to group process, the emphasis on the study of Gestalt therapy's philosophical and epistemological foundations, attention to the individual-environment field and sociocultural and economic factors, and community oriented mental health services, as well as the Brazilian style of contact and other cultural differences, are pointed out as a valuable intrinsic part of Gestalt therapy work in Brazil. Furthermore, considering the questionings and transformations that the Gestalt therapy community have had worldwide in the 1980s and 1990s, the author compares Gestalt therapy of yesterday and today, considering gains and losses, and envisioning the future of Gestalt therapy, reflects on some of the challenges she perceives as common to us all.
Evaluación del efecto de la aplicación de fertilizantes químicos y biofertilizantes en el cultivo del cilantro Coriandrum sativum L.
Authors: Artunduga Lemus Fermín , Quintero Guerrero Yaqueline
Published: April 2022

El cilantro Coriandrum sativum L. es una planta medicinal y aromática herbácea de gran interés industrial debido a sus frutos (semillas). Con el objetivo de evaluar efecto de la aplicación de fertilizantes químicos y biofertilizantes en el cultivo del cilantro, se desarrolló un diseño estadístico completamente al azar con 4 tratamientos que fueron: T0: control, T1: biofertilizante líquido y cosechado a los 20 días, T2: biofertilizante líquido y cosechado a los 40 días, T3: fertilización química + biofertilizante líquido cosechado a los 20 días y T4: fertilización química + biofertilizante líquido cosechado a los 40 días. El experimento se realizó en la granja de Centro Agroempresarial y Desarrollo Pecuario del Huila del Servicio Nacional de aprendizaje (SENA), se utilizaron semillas de cilantro Coriandrum sativum L, variedad patimorado (pureza del 90 %, germinación del 90%) sembrado a chorrillo en tres surcos a una distancia de siembra de 25 cm, en eras de 1 x 7 mts de área. Las variables respuesta que se evaluaron fueron: 1) número de hojas, 2) diámetro y largo del tallo, 3) diámetro y largo de la raíz y 4) peso del hidrolato extraído. Los análisis estadísticos mostraron una diferencia significativa entre el T4 con respecto a los demás tratamientos donde se obtuvo un mayor resultado en el diámetro y largo del tallo, número de hojas y cantidad de hidrolato, mientras que el tratamiento que obtuvo menor diámetro y largo de tallo, número de hojas y cantidad de hidrolato fue el T0 (P ≤ 0,05). En este sentido la utilización de fertilizantes químicos más biofertilizante se convierte en una buena opción que pueden utilizar los agricultores para este tipo de cultivos.
Sistema de Información Geográfico del Centro Agroempresarial y Desarrollo Pecuario del Huila para el análisis cartográfico de sus unidades productivas- SIGCADPH
Authors: Polanía-Dussán Hugo Fernando , Silva-Plazas Jesús Andrés
Published: April 2022

Este artículo corresponde a la implementación de un aplicativo web de un sistema de información geográfico para el Centro Agroempresarial y Desarrollo Pecuario del Huila llamado SIGCADPH. Se desarrolló un primer prototipo dirigido a la granja del SENA Garzón, donde se utilizaron herramientas y equipos tecnológicos. La información recolectada y procesada en la plataforma SIGCADPH Versión 0.10, consistió básicamente en la georreferenciación de lagos, geomembranas, lotes de siembra, invernaderos automatizados, densidad arbórea, visualización de bacterias en las lagunas de oxidación , temperatura y pH del agua, buscando satisfacer las necesidades geográficas en gestión agropecuaria y la asistencia técnica especializada con datos tabulados y graficados. Dicho sistema tiene como objetivo evaluar un sistema piloto que pueda ampliarse a todo el sector agropecuario del centro del departamento del Huila.