bluuebunny/crossref_metadata_2025 huggingface dataset:
WITHDRAWN: New Breakthrough in Triple-Negative Breast Cancer Treatment: A Study on the Clinical Efficacy and Safety of the Combination of Carrilizumab and Apatinib in Dual-Targeted Neoadjuvant Therapy
Authors: YIN Yulai , ZHANG Xiaoyu
Published: December 2023

Objective To investigate the clinical efficacy and safety of dual-targeted neoadjuvant therapy combining carrilizumab with Apatinib in patients with triple-negative breast cancer.
Methods This study collected data from 76 patients with triple-negative breast cancer, confirmed as PD-L1 positive (CPS ≥ 1%) via immunohistochemistry and core needle biopsy, treated at Cangzhou Central Hospital from March 2021 to March 2022. Patients were randomly divided into a control group (n=38) and an observation group (n=38). Based on the standard AT chemotherapy regimen, the control group received treatment with the PD-1 inhibitor carrilizumab, while the observation group was treated with a combination of carrilizumab and the anti-angiogenic drug Apatinib. After completing neoadjuvant therapy, the objective response rate, major pathological response rate, pathological complete response rate, breast conservation rate, CD4+ T lymphocyte subpopulation levels, vascular endothelial growth factor levels, and Ki-67 and PD-L1 expression were compared between the two groups.
Results After four cycles of neoadjuvant therapy, the observation group showed a superior major pathological response rate, pathological complete response rate, and elevated CD4+ T lymphocyte levels compared to the control group (P < 0.05). There was a significant decrease in the proportion of high Ki-67 expression in the observation group (P < 0.05), and the levels of vascular endothelial growth factor were lower than in the control group (P < 0.05). Although the breast conservation rate was relatively higher in the observation group, the difference was not significant (P > 0.05). The incidence of adverse events was similar in both groups, except for a higher rate of hand-foot syndrome in the observation group (P > 0.05).
Conclusion The dual-targeted neoadjuvant therapy for triple-negative breast cancer showed considerable clinical efficacy in reducing tumor burden and was acceptably safe.
First aid Knowledge and Bystander Willingness to Rescue in Jilin, China: The Mediating Roles of Attitude towards First Aid
Authors: Guo Xinrong , Kassa Getachew Mullu , Ye Lin , Li Junxin , Kang Sijia , Zheng Huiling , Wang Yiwen , Liu Wandi
Published: December 2023

Background
Previous research has been conducted on bystander first aid knowledge, attitudes, and willingness. However, surveys of their willingness to provide first aid as bystanders have shown conflicting results. Jilin Province, China, as an economically underdeveloped region, has a low popularization rate of first aid knowledge, and there is a lack of analysis of the mediating effects on first aid knowledge, attitude, and willingness to rescue. Therefore, this study will investigate the first aid knowledge, attitude, and willingness level of residents in Jilin Province as bystanders, and explore the influencing factors of first aid willingness.
Methods
A cross-section study design using a convenience sampling method was used to recruit participants from 16 communities in 8 regions in Jilin Province, China, from May to August 2021. The study included a total of 1994 participants in the analysis. Logistic regression and mediation analysis were conducted to examine the factors associated with and influence of first-aid attitude as the mediating variable to establish a mediation model of the first-aid mechanism. The strength of the association between the independent variables with the willingness to rescue was analyzed using crude odds ratios (COR) of binary logistic regression and adjusted odds ratios (AOR) of multiple logistic regression. Statistical significance was declared when the p-value was < 0.05.
Results
Only 366 (18.4%) had a high level of willingness. The results of multiple logistic analyses showed that gender, occupation, education level, and income level were significantly associated with willingness to rescue. The intermediary analysis found that first-aid attitude was the mediator between first-aid knowledge and willingness, and the mediating effect accounted for 59.70% of the total effect.
Conclusions
The willingness of residents in Changchun to receive first aid is at a relatively low level, which is influenced by gender, occupation, education level, and economic level. Relevant units and departments should increase training efforts and develop corresponding training management strategies based on the characteristics of the population to promote the popularization of public first aid knowledge and improve the success rate of first aid.
Prediction of Greenhouse Gases Solubility in Eutectic Solvents using COSMO-RS
Authors: Pelaquim Fernanda Paludetto , Vilas-Boas Sérgio M. , Nascimento Débora Costa , Carvalho Pedro Jorge , Neto Antonio Marinho Barbosa , Costa Mariana Conceição
Published: December 2023

Over the past few years, eutectic solvents (ESs) have been drawing the scientific community's attention because they are usually more environmentally friendly than traditional organic solvents. One of the applications of ESs is in the gas capture field, where they are considered promising absorbers to replace amine- (MEA, DEA, or MDEA processes), methanol- (Retinol process), dimethyl ethers of polyethylene glycol- (Selexol process), N-methyl-2-pyrrolidone- (Purisol process), propylene carbonate- (Fluor solvent process), or morpholine-based (Morphysorb process) solvents on CO2 capture of atmosphere. Although several studies have reported experimental gas solubility data in ESs, especially for CO2, only a small number of the existing options are covered. In fact, resorting to experimental methods to obtain the solubility data seems unfeasible considering the vast number of possible eutectic mixtures. Therewith, theoretical predictions of gas solubility in ESs are valuable for the fast pre-screening of prospective solvents. In this work, the ability of the COSMO-RS thermodynamic model to represent solubility data of CO2, CH4, and H2S in 17 Choline Chloride-based (ChCl) ESs was evaluated. The experimental data were collected from the literature at different molar ratios, at 298.15 K or 313.15 K, and in the pressure range from 1 to 125 bar. COSMO-RS offers a qualitative description of these gases' solubility, which was expected due to the model's fully predictive character.
Toripalimab combined with albumin-paclitaxel plus gemcitabine as first-line treatment for locally advanced or metastatic pancreatic ductal adenocarcinoma: an open-label, phase Ib/II study and investigation of potential biomarkers
Authors: Cao Dan , Cheng Ke , Zhao Gang , Lv Wanrui , Li Xiaoying , Chang Chen , Yang Heqi , Li Ruizhen , Zhang Yi , Xiong Junjie , Huang Zixing , Shao Weikang , You Xin , Guo Wenhao , He Du , Ling Wenwu , Wang Rui , Zhao Chengjian , Tian bole
Published: December 2023

Advanced pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Immunotherapy alone offers limited efficacy, but its combination with chemotherapy could offer synergist anti-tumor effects. This phase Ib/II study evaluated the safety and efficacy of combining toripalimab with the albumin-paclitaxel plus gemcitabine (AG) regimen as first-line treatment for locally advanced or metastatic PDAC. The primary endpoints were safety and overall survival (OS). The secondary outcomes were objective response rate (ORR), disease control rate (DCR), and progression-free survival (PFS). Immune-related biomarkers including programmed death-ligand 1 (PD-L1) expression, genetic status, cytokine levels, and immune microenvironment were investigated. Among the 72 patients enrolled, the median OS was 8.8 months, and the 12-month OS rate was 33.3%. No serious treatment-related adverse events, grade 4 immune-related adverse events, or treatment-related deaths were reported. The combination therapy led to a median PFS of 5.3 months, ORR of 33.3%, and DCR of 90.3%. Non-liver metastasis status predicted a better PFS, and the number of lesion sites and baseline CA199 level were independently associated with OS. One patient (1.4%) with mismatch repair deficiency achieved pathologic complete response and prolonged OS > 19 months. Higher PD-L1 expression was associated with a better ORR than lower expression (56.3% vs 25%), and a higher CD3 + cell density, decreased CD68 + cell infiltration, and lower baseline serum interleukin-8 level were associated with better treatment response. Overall, AG plus toripalimab exhibited a certain level of safety and probable clinical efficacy for locally advanced or metastatic PDAC, especially in some potentially advantaged subgroups.
Artificial Intelligent Tools: Evidence-Mapping on the Perceived Positive Effects on Patient-Care
Authors: Botha Nkosi Nkosi , Ansah Edward Wilson , Segbedzi Cynthia Esinam , Dumahasi Victor Kwasi , Maneen Samuel , Kodom Ruby Victoria , Tsedze Ivy Selorm , Akoto Lucy Adjanor , Atsu Fortune Selasi
Published: December 2023

The global healthcare system is fraught with serious challenges including scarcity of critical healthcare professionals, changes in disease patterns, pandemics, access and equity issues among others. Considering that there is no quick fix to the myriad of healthcare challenges, World Health Organisation proposed a full integration of artificial intelligent (AI) tools into patient-care to stimulate efficiency and guarantee quality in patient-management. Therefore, this review maps evidence on the perceived positive effects of AI tools on patient-care. The review considered time expand between January 1, 2010 and October 31, 2023. Consistent with the protocol by Tricco et al., a comprehensive literature search was executed fromNature, PubMed, Scopus, ScienceDirect, Dimensions, Ebsco Host, ProQuest, JStore, Semantic Scholar, Taylor & Francis, Emeralds, WHO, and Google Scholar. Upholding the inclusion and exclusion standards, 14 peer reviewed articles were included in this review. We report the use of that AI tools could significantly improve accuracy of clinical diagnosis and guarantee better health-outcomes of patients. AI tools also have the ability to mitigate, if not eliminate, most of the factors that currently predict poor patient outcomes. Furthermore, AI tools are far more efficient in generating robust and accurate data in real-time, and could help ease and accelerate the workflow. If properly integrated into the healthcare system, AI could help accelerate the attainment of Sustainable Development Goals 3.4, 3.8, and 3.b. We propose that AI developers collaborate with public health practitioners and healthcare managers to develop AI applications that appreciate socio-cultural dimensions in patient-care.
How choices in plant material and plantation practices (variety, rootstock, planting density and vine age) affect grapevine yield for main wine labels. Analysis of a big dataset from surveys to winegrowers in Languedoc-Roussillon.
Authors: Fernandez-Mena Hugo , Gautier Marine , Metay Aurelie , Hannin Hervé , Gary Christian
Published: December 2023

In vineyards, decisions regarding plant material and plantation practices are crucial for winegrowers when planning future vine plots. These choices often navigate within the bounds set by wine labels and are contingent upon a spectrum of management options. However, the comprehensive influence of these decisions on grapevine yield at a large scale remains a relatively unexplored domain. A deeper understanding of how plant material and planting strategies impact grapevine yield stands as a potential avenue for mitigating yield losses, especially exacerbated by the repercussions of climate change, thereby ensuring sustainable wine production. In this study, we employed random plot data from national surveys conducted among winegrowers in the Languedoc-Roussillon viticultural region (n = 3507). Our analysis focused on examining the relationship between grapevine yield and: i. plant material (varieties, rootstocks); ii. plantation practices (planting density, vine age); considering diverse vineyard management approaches (wine label, organic management, irrigation). Data analysis encompassed graphical observations, statistical tests, and modeling to evaluate the impact of these factors on grapevine yield. Our findings indicate that most cultivated varieties exhibited similar yield levels for the same type of wine label. Notably, SO4 rootstock displayed the best yield performance across multiple cultivated varieties. The combined influence of vine age and wine label explained up to 40% of the total yield variance. We observed a minor adverse effect of vine aging on grapevine yield, particularly in highly productive vineyards under the PGI wine label. However, the impact of vine age on yield in PDO wine plots was almost negligible. Organic management did also demonstrate an influence on yield. Unexpectedly, planting density did not significantly affect yield. These results underscore the significance of conducting real winegrowers' big data analysis at a regional level, particularly in connection with wine label and management choices.
Identity Politics in the Construction of Electoral Laws: A Qualitative Analysis
Authors: Jukari Ahmad , Karimullah Suud Sarim , Muhajir Muhajir
Published: December 2023

This article aims to deepen the construction of general election regulations related to representation and identity politics. This research is non-doctrinal with a normative approach, using documentation studies and libraries as data sources. Research findings suggest that the electoral arrangement designs the holding of elections as a tool for preserving national identity and national interests. Although the Electoral Act does not accommodate political representation of a distinctly religious nature, its implementation involves special regulations, such as Special Autonomy for Papua Province, the Government of Aceh, and the Yogyakarta Special Territory Privileges. This regulation gives room for politics of representation based on patriotism, culture, and religion. Furthermore, the Election Act prohibits some campaign actions that could create political nuances of identity. This article is expected to contribute to a further understanding the political dynamics of representation and identity in the context of the Electoral Law in Indonesia.Artikel ini bertujuan untuk mendalami konstruksi pengaturan mengenai pemilihan umum terkait politik representasi dan politik identitas. Penelitian ini bersifat non-doktrinal dengan pendekatan normatif, menggunakan studi dokumentasi dan kepustakaan sebagai sumber data. Temuan penelitian menunjukkan bahwa pengaturan tentang Pemilu merancang penyelenggaraan pemilu sebagai alat untuk menjaga identitas nasional dan kepentingan nasional. Meskipun Undang-Undang Pemilu tidak mengakomodasi politik representasi yang bersifat kedaerahan, kesukuan, dan agama, implementasinya melibatkan regulasi khusus, seperti Otonomi Khusus Bagi Provinsi Papua, Pemerintahan Aceh, dan Keistimewaan Daerah Istimewa Yogyakarta. Regulasi khusus ini memberikan ruang untuk politik representasi berdasarkan kedaerahan, budaya, dan agama. Lebih lanjut, Undang-Undang Pemilu juga melarang sejumlah tindakan kampanye yang berpotensi menciptakan nuansa politik identitas. Artikel ini diharapkan dapat memberikan kontribusi pada pemahaman lebih lanjut tentang dinamika politik representasi dan identitas dalam konteks Undang-Undang Pemilu di Indonesia.
THE EFFECTS OF CALISTHENIC EXERCISES ON SLEEP QUALITY, FATIGUE, AND DEPRESSION IN ELDER ADULTS
Authors: Cetıslı-korkmaz Nilüfer , Kara-cakıcı Güzin , Doğru-hüzmeli Esra , Hüzmeli İrem , Melek İsmet Murat
Published: December 2023

Purpose: The physical, psychological, even economic and environmental changes emerged with age cause problems in sleep. The lack of exercise habits could increase the incidence of unfavorable sleep disorders with depression and fatigue. The aim of this non-randomized controlled study was to investigate the considerable effects of calisthenic exercises on sleep disorders, depression, and fatigue in elder adults.
Methods: The study was conducted at Pamukkale University and Hatay Mustafa Kemal University. Sixty-two individuals participated in the study between May 2018-October 2019. While the Calisthenic Group (n=32) performed calisthenic exercises for 30-45minutes/session and 3days/6weeks, and Control Group (n=30) did not performed. Fatigue, depression, and sleep quality levels were assessed using the Fatigue Severity Scale (FSS), Beck Depression Scale (BDI), and Pittsburgh Sleep Quality Index (PSQI), respectively.
Results: Statistically significant differences among FSS (p≤0.001), BDI (p=0.022), and PSQI (p=0.006) scores were found in the Calisthenic Group after the intervention, while there were differences only in fatigue (p=0.035) and total sleep quality (p=0.035) for the Control Group. We found that the Calisthenic Group’s PSQI latency, PSQI sleep duration and PSQI total scores decreased in post-treatment. Both fatigue severity (p≤0.001) and depression levels (p≤0.001) were highly correlated with PSQI-subscores, except for sleep duration subscore (FSS p=0.934, BDI p=0.276).
Conclusion: Regular calisthenic exercise programs may enable elders to better manage changes in the aging process. Physiotherapists should consider including calisthenic exercises in the rehabilitation programs for its effects on all parameters of sleep, fatigue, mental and emotional status in this population.
Comparison of gene targets and sampling regimes for SARS-CoV-2 quantification for wastewater epidemiology in UK prisons
Authors: Jobling Kelly , Quintela-Baluja Marcos , Hassard Francis , Adamou Panagiota , Blackburn Adrian , Research Team Term , McIntyre-Nolan Shannon , O'Mara Oscar , Romalde Jesus L. , Di Cesare Mariachiara , Graham David W.
Published: December 2023

Prisons are high-risk settings for infectious disease transmission, due to their enclosed and semi-enclosed environments. The proximity between prisoners and staff, and the diversity of prisons reduces the effectiveness of non-pharmaceutical interventions, such as social distancing. Therefore, alternative health monitoring methods, such as wastewater-based epidemiology (WBE), are needed to track pathogens, including SARS-CoV-2. This pilot study assessed WBE to quantify SARS-CoV-2 prevalence in prison wastewater to determine its utility within a health protection system for residents. The study analysed 266 samples from six prisons in England over a 12-week period for nucleoprotein 1 (N1 gene) and envelope protein (E gene) using quantitative reverse transcriptase-polymerase chain reaction. Both gene assays successfully detected SARS-CoV-2 fragments in wastewater samples, with both genes significantly correlating with COVID-19 case numbers across the prisons (p < 0.01). However, in 25% of the SARS-positive samples, only one gene target was detected, suggesting that both genes be used to reduce false-negative results. No significant differences were observed between 14- and 2-h composite samples, although 2-h samples showed greater signal variance. Population normalisation did not improve correlations between the N1 and E genes and COVID-19 case data. Overall, WBE shows considerable promise for health protection in prison settings.
A implementação do turno único nas escolas do município do Rio de Janeiro
Authors: Felix Rosângela Cristina Rocha Passos , Bernado Elisangela da Silva
Published: December 2023

O presente artigo apresenta uma análise sobre a percepção dos gestores escolares e educacionais acerca da implementação da política de Turno Único na Rede Municipal do Rio de Janeiro. A partir de entrevistas semiestruturadas com esses atores, este escrito apresenta o olhar deles sobre os processos para a sua implementação, as concepções de educação presentes na política e seus objetivos. Este estudo, de cunho qualitativo, tem como base os resultados da pesquisa realizada na Unirio de 2019 a 2021. A partir da análise das entrevistas e a observação de documentos legais sobre a implementação do Turno Único, pautada na perspectiva da Tematização (FONTOURA, 2011) para análise dos dados, percebemos nessa política um delinear distinto das anteriores, saindo da visão mais focal e compensatória, e trazendo um olhar universalista. Apesar de serem citados alguns pontos que precisam de atenção, a política é bem vista pelos atores sociais envolvidos e tem potencial expectativa de expansão para toda a Rede pública municipal.
Quantifying research publication efficiency: A comparative analysis of the HY-index and the h-index
Authors: Alzahrani Mohammad Salem J. , Youssef Hamdy M. , Alghamdi Najat A.
Published: December 2023

Efficiently quantifying the scholarly output of researchers, scientists, academic institutions, departments, and universities is of paramount importance within academic circles. This study centers on the application of a novel index known as the HY-Index, designed to evaluate the quality of articles from various sources, with the primary aim of addressing the limitations associated with established indices, notably the widely-used h-index. We deploy the HY-Index alongside the h-index to assess the performance of the top fifty researchers affiliated with Umm Al-Qura University, using data from the Google Scholar database. Comparative analyses are conducted, and rankings based on the HY-Index and h-index are scrutinized to determine which index offers a more suitable approach for quantifying researcher efficiency. Our findings reveal that the linear trend equation of the HY-Index rank closely aligns with the linear trend equation of the citation rank, surpassing the alignment observed with the h-index rank. Additionally, the linear trend equation of the HY-Index rank exhibits greater similarity to the linear trend equation of the publications rank compared to the h-index rank. Consequently, the HY-Index provides a more precise means of assessing author quality based on both citation and publication rankings, offering a fairer measurement of author quality compared to the h-index.
Analysis of Factors Affecting Customer Satisfaction in the Context of Online Shopping in Pakistan
Authors: Islam Zohaib
Published: December 2023

The purpose of this research is to explore the relationships between product quality, service quality, trust, delivery guarantee, and customer satisfaction in the context of online shopping in Pakistan. The research philosophy adopted for this study is positivism, with a quantitative research design using deductive approach. The sample design is non-probabilistic, and convenience sampling was used to select the participants. The sample size of 202 respondents was determined using heuristic sampling. Partial Least Square Structural Equation Modeling (PLS-SEM) was employed as the statistical technique for data analysis. The study found that product quality, service quality, trust, and delivery guarantee significantly influenced customer satisfaction. Moreover, trust mediated the relationship between product quality and customer satisfaction, as well as the relationship between service quality and customer satisfaction. This study provides valuable insights into the factors that contribute to customer satisfaction in the context of online shopping in Pakistan. Moreover, it contributes to the literature on the relationship between trust and customer satisfaction by exploring the mediating role of trust in the context of online shopping.
Developmental Funding and Nurturing in Colleges and Universities in the New Era: Dilemmas - Paths - Significance
Authors: Sun Xiaoning , Liu Yantao
Published: December 2023

Doing a good job of financial aid and education in colleges and universities can help consolidate the results of China's current poverty alleviation efforts, combining "poverty alleviation with helping the wise and the ambitious" to achieve the goal of "blood transfusion", but also "blood-creation", to help students from economically disadvantaged families successfully complete their studies, and to maintain national security and stability. To help students with family economic difficulties to successfully complete their studies, to achieve social justice, and to maintain national security and stability. This paper explores the problems faced by colleges and universities in the new era in promoting the development of financial support for people, and proposes solutions to the great significance of developmental funding. Push the funding to a more in-depth development, to help students grow and achieve success, to achieve the overall development of students.
ANTICANCER POTENTIAL OF SALACIA CHINENSIS L. AND WOODFORDIA FRUTICOSA (L.) KURZ OF THE WESTERN GHATS FORESTS OF INDIA
Authors: KC NINADA , N. BHAGYA , WJ RODRIGUES , R. CHANDRASHEKAR , K. R. CHANDRASHEKAR
Published: December 2023

Objective: Salacia chinensis and Woodfordia fruticosa are medicinal plants from the Western Ghats of India traditionally used in the treatment of diabetes, diarrhea and worm infections. The current study aims to evaluate the cytotoxic potential of methanolic extract of Salacia chinensis and Woodfordia fruticosa against breast and pancreatic cancers.
Methods: Methanolic extract of dried leaves of Salacia chinensis and Woodfordia fruticosa were obtained by Soxhlet extraction. The cytotoxic potential of the dried extract was evaluated against human breast (MDA-MB-231) and pancreatic (PANC-1) cancers in vitro using MTT-based assay.
Results: The study showed a dose-dependent cytotoxicity of Salacia chinensis and Woodfordia fruticosa leaf extracts against breast and pancreatic cancers with IC50 values of 124 μg/ml against MDA-MB-231 and 230.5 μg/ml against PANC–1 cells, respectively.
Conclusion: Results indicate the presence of cytotoxic phytochemicals in Salacia chinensis and Woodfordia fruticosa. Further purification of the extract might be beneficial to isolate the anticancer phytochemical.
Critical Discourse Analysis on China’s Image in Climate Coverage by Mainstream US Media
Authors: Yanhua Zhang , Weina Li
Published: December 2023

In the trend of information globalization, mass media is not only an authoritative source of information but also a participant and executor of international affairs. News reporting is the most influential and authoritative form of media, shaping people’s cognition and attitudes while conveying information. Therefore, using news reports to build a national image has become an essential strategy for the government of a country. At the same time, an excellent national image is essential for improving a country’s global discourse power. Therefore, this paper uses discourse-historical analysis as a theoretical framework to analyze the China-related climate reports of mainstream media in the United States from 2015 to 2023 and explores the diachronic changes and reasons for the image of China in mainstream media reports in the United States. In this study, a combined approach of quantitative and qualitative methods is employed, with a particular emphasis on data-driven corpus research methods. The study found that mainstream US media’s climate reporting on China mainly focuses on China’s climate responsibility, renewable energy, and inter-country relations in climate governance. Through the analysis of the predication strategy, argumentation strategy, and intensification strategy, it is found that the media’s stance has gone through a period of neutrality from 2015 to 2017, increased hostile rhetoric from 2018 to 2019, and continued to worsen from 2020 to 2023. The media’s stance is mainly related to the changes in climate policies in the United States at different phases.
Bio Evaluation of Lantibiotic Nisin Loaded Polyvinyl Alcohol – Sodium Alginate Crosslinked Hydrogel As Novel Dental Temporary Filling Material
Authors: Chandran Mridula R. , Usha R.
Published: December 2023

The incidence of oro-dental disorders has emerged as a serious threat to the healthcare sector owing to the increasing complexity of the oral microbiome. Significant advances in biomaterial research have led to the advent of a plethora of drug delivery systems including nanocarriers, dendrimers, hydrogels and other kinds of stimuli-responsive polymeric biomaterials. Anti-microbial peptides (AMPs) have engendered considerable interest in the past decades as potential alternatives to traditional disinfecting agents and also emerged as potent antibiofilm agents. Among the most viable approaches in targeted drug delivery, hydrogels incorporated with AMPs are emerging as bio-functional platforms yielding increased stability and bioavailability. The antibacterial and antibiofilm activities of Nisin are studied using microbiological methods followed by the synthesis of Nisin loaded PVA-Alginate hydrogel for dental treatment. The physicochemical characteristics of Nisin loaded hydrogel were done by swelling behavior, release kinetics assay, FTIR spectroscopic methods and cytotoxicity studies. Nisin showed antibacterial activity towards clinical isolates of drug-resistant bacteria and the antibiofilm and anti-adhesion studies demonstrated that Nisin could control the bacterial count in the test sample. The polymerization of Nisin into hydrogels was done and the physico-chemical characterization of Nisin loaded hydrogel network could be envisaged as a potential drug delivery platform for oral infections. Nisin loaded PVA-Alginate biocompatible hydrogel exhibited apparent swellable, flexible, nonhaemolytic materials and active antimicrobial and nontoxic materials. Physicochemical properties of these Nisin loaded PVA-Alginate biocompatible hydrogels have great potential in biomaterial-based drug delivery systems in controlling the growth and proliferation of major oro-dental pathogens. This could be exploited for the temporary biocompatible dental filling materials to treat the caries. Exploring potential nisin loaded hydrogel delivery systems will provide a brighter future of more friendly, effective and personalized treatment to deal with dental caries.
Comorbidities and their Impact on COVID-19 Severity
Authors: Maqsood Quratulain , Hussain Nazim , Mumtaz Mehvish , Wajid Abdul , Sumrin Aleena
Published: December 2023

The current COVID-19 pandemic is caused by the novel SARS-CoV-2 coronavirus strain. Although SARS-CoV-2 infection can affect everyone, the kind and degree of infection and sickness vary widely between individuals and populations. It has been crucial since reported disease loads and case fatality rates vary greatly among countries. However, there are still uncertainties about the severity of the illness in certain people and, in other cases, the aetiology of a more severe illness. Various chronic conditions, such as diabetes, cardiovascular diseases, respiratory ailments, and immunodeficiency disorders, have been identified as significant risk factors for COVID-19. These comorbidities not only increase the susceptibility to contracting the virus but also exacerbate the severity of symptoms and the likelihood of adverse outcomes, including hospitalization, intensive care unit admission, and mortality. The objective of this article is to point out the proliferation of COVID-19 in relation to different diseases affecting the clinical outcome of COVID-19. The study included 1500 patients with various diseases such as HCV, HBV, kidney disease, heart disease, asthma, T.B., arthritis, smokers, and vaccinated or unvaccinated. Results showed that 22% of diabetic patients, 40% of heart patients, 40% of asthma patients, 26% of kidney patients, 25% of T.B patients, and 41% of smokers had high corona positive. Coronavirus positivity was found in 34% of vaccinated patients and 72% of non-vaccinated patients, with an overall calculated p-value of 0.0001 by ANOVA statistical analysis. The overall outcome of the results showed that the severity of Corona disease increased in relation to different diseases.
Anti-Staphylococcus aureus Activity of the Aqueous Ethanolic Extract of Solenostemma argel Aerial Parts
Authors: Alkuwayti Mayyadah Abdullah
Published: December 2023

Solenostemma argel (Asclepiadaceae) is a beneficial folk medicine used to treat many diseases, including the kidney, liver, and stomach diseases. The aim of this study was to assess the anti-Staphylococcus aureus activity of an aqueous ethanolic extract of Solenostemma argel (AEESA) and identify its phenolic and volatile compounds using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectroscopy (GC-MS). As revealed using the disc diffusion test and DNA cleavage analysis, S. argel extract was active against Staphylococcus aureus. The minimum inhibitory concentration (MIC) was 31.6 g/mL. Sixteen phenolic compounds of AEESA were analyzed using HPLC, wherein the phenolic compounds: pyrocatechol (9519.95 µg/g), ferulic acid (3221.41 µg/g), chlorogenic acid (3221.41 µg/g), and gallic acid (2730.85 µg/g) were the most abundant. Additionally, naringenin (2262.80µg/g) and quercetin (1750.25µg/g) were the major flavonoids. GC-MS analysis of AEESA revealed 30 volatile compounds, the major percentages of 9,12-octadecadienoic acid (z,z)-, methyl ester (33.44%), ascorbic acid 2,6-dihexadecanoate (7.22%), and butylated hydroxytoluene(5.46%), followed by 2-Pentadecanone, 6,10,14-trimethyl (4.77%), 2-Pentadecanone, 6,10,14-trimethyl (3.35%), Stigmasta-5,22-dien-3-ol, and acetate (3.Beta; 3.35%). The application of S. argel extract in reducing the growth of biofilms would subsequently diminish the development of antibiotic resistance and promote the future uses of plant extract components.
Clinico Mycological Profile of Dermatophyte Infections at A Tertiary Care Hospital from South India
Authors: Preethi Pellakuru , Narasimhan Murali , Datchanamoorthy Maheswary , Hemamalini  , Bharathi Muthu , Vajravelu Leela Kakithakara
Published: December 2023

The prevalence of Dermatophytosis is similar in several continents of the Asian country. The varied state of weather is favourable for mycosis that may lead to various clinical symptoms and infection spreads speedily if left untreated with time. The aim of the present study is to determine the clinical and mycological pattern of dermatophyte infections in patients arriving at our dermatology outpatient department and also to correlate the formal clinical diagnosis with KOH positivity and culture positivity. This descriptive observational study was conducted among 300 patients presenting with dermatophyte infections who came to the dermatology outpatient Department of SRM Medical College and research centre, Kattankulathur, Chengalpattu. The clinical specimens were put through direct microscopy by Potassium Hydroxide (KOH) mount and with the culture on Sabouraud’s Dextrose Agar (SDA). The study showed males were affected mostly and most of the participants were students. The common symptoms observed were Itching, Scaling and Discolouration. Commonly, patients had a primary diagnosis of Tinea corporis infection followed by T. cruris. Trichophyton mentagrophytes were the commonly isolated organism followed by Trichophyton rubrum and Trichophyton violaceum. This study indicates the need for personal hygiene and the disadvantage of as only few participants had zoophilic infections of Tinea species. These methods of diagnosing and identification will further aid in better patients management.
A Comprehensive Overview of the Unequivocal Influence and Evolution of Cryptography on Security
Authors: Jain Aadya
Published: December 2023

Abstract: As this society unfolds into a conundrum of new possibilities and technical advancements, it simultaneously sets ground to several unprecedented challenges for its users. What today’s digitally ensnared society doesn’t understand is its vulnerability to malicious software, cyber attacks, and innumerable privacy violations that come their way as they mold themselves into this digital realm. For a country like India, that well adapts to the newer technologies invented across the globe, it is astonishing to see almost 1.3 million cybersecurity breaches being recorded in 2022, a hideous spike from 2019. Current internet users feel the need to be active on such delusional platforms every minute of their day, exposing themselves at every stage. This empowers unethical practices and practitioners to lure unsuspecting candidates into their traps and obtain private information linked to several sensitive, especially monetary affairs of the individual, consequently resulting in severe financial losses. Ironically, the very technological influence that facilitates security breaches is one that helps in its deterrence and prevention. One of the most predominant and recent technologies that have empowered its influence over such prevention is cryptography and encryption. Traditionally, prior to the widespread awareness about cryptography, companies and individuals used Access Control Lists(ACLs) that work on the basic principle of restricting or revoking access on certain administrative grounds offering data confidentiality and security on the internet. Apart from these companies, in the ancient times, there was significant use of Caesar Cipher, a way of encryption that works on the principle of substitution by a shift of some number down the alphabet. These traditional methods lacked transparency, had increased complexity, were insufficient for rapidly growing networks such as online social media, and also lacked scalability. In order to compensate for these challenges, a newer technology concatenated with cryptography is to be made prevalent in society so that it can offer more scalable and trustworthy encryption and security prevention from online security breaches across the globe. With this ideology, prevention and awareness both can be obtained and a better and safer society can be established in this generation.
Pengaruh Harga dan Promosi Terhadap Keputusan Pembelian Konsumen
Authors: Negara I Made Wreddhi , Febianti Febianti , Paramita Putu Dian Yuliani
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh harga dan promosi terhadap keputusan pembelian konsumen di Rumah Coffee & Community Hub. Waktu penelitian dilaksanakan tepatnya pada bulan Januari – Juni 2021. Populasi dari penelitian ini adalah pelanggan atau konsumen yang telah melakukan pembelian di Rumah Coffee & Community Hub pada bulan Juni 2021. Penelitian ini menggunakan sampel sebanyak 40 responden. Teknik pengambilan sampel untuk menentukan sampel yang akan digunakan dalam penelitian ini menggunakan teknik non-probability sampling yaitu accidental sampling. Data dikumpulkan dengan menggunakan kuesioner dan dokumentasi, kemudian dilakukan analisis kuantitatif, meliputi: uji validitas, uji reliabilitas, uji asumsi klasik, analisis regresi linear berganda, serta pengujian hipotesis melalui uji F dan uji t. Hasil penelitian menunjukan harga dan promosi secara simultan berpengaruh positif dan signifikan terhadap keputusan pembelian konsumen dengan tingkat signifikansi 0,000. Harga secara parsial berpengaruh positif dan signifikan terhadap keputusan pembelian konsumen dengan tingkat signifikansi 0,036. Promosi secara parsial berpengaruh positif dan signifikan terhadap keputusan pembelian konsumen dengan tingkat signifikansi 0,003. Hasil tersebut mengindikasikan bahwa untuk meningkatkan keputusan pembelian konsumen di Rumah Coffee & Community Hub, manajemen perlu memperhatikan faktor-faktor harga dan promosi karena faktor-faktor tersebut terbukti mempengaruhi keputusan pembelian konsumen.
 
This study aims to determine the effect of price and promotion on consumer purchasing decisions at Rumah Coffee & Community Hub. The time of the research was carried out precisely in January - June 2021. The population of this study were customers or consumers who had made purchases at Rumah Coffee & Community Hub in June 2021. This study used a sample of 40 respondents. The sampling technique used to determine the sample to be used in this study was a non- probability sampling technique, namely accidental sampling. Data were collected using questionnaires and documentation, then quantitative analysis was carried out, including: validity test, reliability test, classical assumption test, multiple linear regression analysis, and hypothesis testing through F test and t test. The results of the study show that price and promotion simultaneously have a positive and significant effect on consumer purchasing decisions with a significance level of 0.000. Price partially has a positive and significant effect on consumer purchasing decisions with a significance level of 0.036. Promotion partially positive and significant effect on consumer purchasing decisions with a significance level of 0.003. These results indicate that to improve consumer purchasing decisions at Rumah Coffee & Community Hub, management needs to pay attention to price and promotion factors because these factors are proven to influence consumer purchasing decisions.
Interesse recursal no incidente de resolução de demandas repetitivas
Authors: Sampaio Carnelós Rubens
Published: December 2023

Objetivo: o presente trabalho tem como objetivo fazer uma análise do interesse recursal na perspectiva do incidente de resolução de demandas repetitivas. Para tanto, será necessário, inicialmente, indicar o conceito e as características do incidente de resolução de demandas repetitivas. Pretende-se apresentar as visões da doutrina sobre o referido incidente, adotando, com base em uma visão crítica, que sua função principal é servir como técnica processual para preservar a coerência da ordem jurídica. Após essa apresentação, o objetivo será apontar a compreensão que a doutrina construiuhistoricamente sobre o interesse recursal, indicando suas características e controvérsias sobre seu conceito. Método: o estudo está apoiado em levantamento bibliográfico, mormente em doutrina que enfrenta a questão do interesse recursal no incidente de resolução de demandas repetitivas, além da análise da jurisprudência do STF e do STJ. Com a análise, busca-se apontar em que medida o interesse recursal deve ser repensado para atender as finalidades do incidente de resolução de demandas repetitivas, indicando o modo como os tribunais têm entendido a questão. Resultado: concluiu-se que é necessário redimensionar o conceito de interesse recursal, de modo que se viabilize a potencialidade do incidente de resolução de demandas repetitivas, sobretudo no aspecto de conferir mais segurança jurídica à função jurisdicional.
Genetic Divergence among On-farm Collections for Yield and Yield-related Traits in Ginger (Zingiber officinale R.)
Authors: TUMMINAKATTI ALTAF , Fakrudin B , Maruthiprasad B. N. , Vishnuvardhana  , Suresha G. J. , Manjunath G. , Venkatesha J.
Published: December 2023

The present investigation was carried out at the farmer’s field Neshwi village, Haveri District of Karnataka, India during kharif season (May, 2021 to January, 2022). The improvement of crop relies heavily on genetic diversity. The objective of the study was to assess the genetic divergence of 76 diverse genotypes of ginger collected from different parts of the Karnataka, India which including four checks. The genetic divergence of ginger genotypes was assessed using Mahalanobis D2 statistics. Genetic divergence studies revealed considerable genetic diversity among 76 genotypes of ginger for a set of ten quantitative traits pertaining to the growth and yield characters viz., height of the shoot (cm), leaf area (cm2), number of primary rhizomes, length of the primary rhizome (cm), girth of the primary rhizome (cm), number of secondary rhizomes, length of the secondary rhizome (cm), girth of the secondary rhizome (cm), crop duration (number of days) and rhizome yield plant-1 (g). Analysed 76 ginger genotypes were clustered based on similarities between their D2 values using Tocher’s method, resulting in 14 distinct groups. Considerable diversity within and between 14 clusters was observed among the genotypes. The characteristics such as average rhizome yield plant-1, girth of the primary rhizome and length of the primary rhizome were the main factors in differentiating the genotypes of ginger studied. Utilizing genotypes from clusters with high inter-cluster distances, such as clusters VI and XIII, VI and XIV and X and XIV can form potential pre-breeding material for the improvement of ginger crop.
Kajian kelayakan teknis dan tekno ekonomi pembangunan jalur ganda kereta api antara Tanjung Karang – Kotabumi
Authors: Usman Kristianto , Kustiani Ika , Siregar Amril Ma'ruf , Junaidi Tas'an
Published: December 2023

Kajian ini bertujuan untuk: mengkaji kebutuhan jalur ganda kereta api lintas Tanjung Karang – Kotabumi; mengkaji kelayakan teknis dan tekno ekonomi pembangunan jalur ganda kereta api antara Tanjung Karang – Kotabumi; memberikan rekomendasi teknis berdasarkan hasil kajian kepada pihak terkait sebagai bahan pertimbangan pada tahapan pembangunan. Metode yang dilakukan adalah kajian teknis berdasarkan standar yang berlaku, dan kajian untuk menilai parameter-parameter tekno ekonomi berdasarkan tiga skenario arus pemasukan (revenue streams), yang meliputi skenario pesimis, most likely (berpeluang terjadi), dan optimis. Hasil kajian pada parameter-parameter terkait, menunjukkan nilai estimasi NPV (Net Present Value) positif; IRR (Interest Rate of Return) antara 6,57% dan 17,90%, BCR (Benefit Cost Ratio) antara 1.55 and 2,52, and BEP (Break Event Point) bervariasi mulai dari tahun keenam sampai tahun kesepuluh untuk tiga skenario tersebut. Berdasarkan hasil kajian, dapat disimpulkan bahawa proyek layak secara teknis dan tekno ekonomi, serta dapat diimplementasikan untuk meningkatkan kapasitas lintas KA barang dan penumpang.
Pengaruh Iklim Kerja dan Motivasi Berprestasi terhadap Kinerja Guru Madrasah Tsanawiyah Negeri Kota Pekanbaru
Authors: Pohan Rahmadanni
Published: December 2023

This research aimed to find out whether there was a significant effect of work climate and achievement motivation on teachers’ performances of State Islamic Junior High School in Pekanbaru. Used correlation method with quantitative approach. The total number of respondents was 30 teachers. Technique of collecting the data used observation, questionnaire and documentation. Technique of analyzing the data used qualification test which consists of normality test, linearity and homogeneity test, and hypothesis test which was done by using simple correlation analysis, multiple correlation and determination analysis (R2) which entirely used SPSS version 22.0. The result showed that work climate gave effects on teachers’ performances of Islamic State Junior High School in Pekanbaru which was at a very strong category was 0.989, achievement motivation gave effects on teachers’ performances of Islamic State Junior High School in Pekanbaru which was at a very strong category was 0.993. Furthermore, work climate and achievement motivation simultaneously gave effects on teachers’ performances of Islamic Junior High School which was at a very strong category was 0.994. If work climate and achievement motivation increase, teachers’ performances of Islamic State Junior High School in Pekanbaru will be higher. Conversely, if the work climate and achievement motivation decrease, teachers’ performances of Islamic State Junior High School in Pekanbaru will be lower. From these results, it is expected that teachers can maintain and enhance their performance in completing the tasks optimally.
Majelis Ta’lim sebagai Model Pendidikan Non Formal Islam
Authors: Zuhri Zuhri
Published: December 2023

The article wants to discuss the existence of the majelis ta'lim as one model of Islamic non-formal education. The discussion uses a qualitative descriptive method by examining library sources and supported by field data. The results of the discussion show that majelis ta’lim is one of non formal Islamic Education system, majelis ta’lim has role and function that is very important in growing and developing of Islamic education. The implementation of this education can help to understand the developing process in religious and community life for members of majelis ta’lim. Now a days, function and role of majelis ta’lim is reducted, so that lack and not optimal for the people. Generally majelis ta’lim is held potluck, as decitation group, the recitation that was held by muslim especially female voluntarily, and without preparation.