bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Patients With Locally Advanced Gastric Cancer Who May Benefit From Adjuvant Chemoradiotherapy After D2 dissection: A Propensity Score Matching Analysis
Authors: Wang Shu-Bei , Qi Wei-Xiang , Chen Jia-Yi , Xu Cheng , Cao Wei-Guo , Cai Rong , Cao Lu , Cai Gang
Published: April 2021

Background

One of the most controversial areas in gastrointestinal oncology is the benefit of postoperative chemoradiotherapy (CRT) over chemotherapy (CT) alone after D2 dissection of locally advanced gastric cancer (LAGC). We aimed to identify the LAGC patients who may benefit from adjuvant CRT.

Methods

We analyzed retrospectively 188 patients receiving radical gastrectomy with D2 dissection for LAGC in our hospital. Patients were divided into two balanced groups by using propensity score matching: CRT group (n = 94) received adjuvant CRT, and CT group received adjuvant CT alone.

Results

At a median follow-up of 27.10 months, 188 patients developed 79 first recurrence events (36 in CRT group and 43 in CT group). Our results showed that adjuvant CRT significantly decreased the risk of developing local regional recurrence (LRR) when compared to CT alone (14.9% vs. 25.5%, p = 0.044), while the estimated 3-year disease-free survival (DFS) was comparable between the CRT and CT groups (59.3% vs. 50.9%, p = 0.239). In the subgroup analysis, a significantly decreased LRR rate was also observed in LAGC patients with N1-3a stage after adjuvant CRT (p = 0.046), but not for N3b. Para-aortic lymph nodes (station No. 16) were the most frequent sites of LRR. After receiving radiotherapy, recurrence of 16 a2 region and 16 b1 region were significantly deceased (p = 0.026 and p = 0.044, respectively). Patients who received irradiation more than 4 months after surgery showed an increased risk of LRR (p = 0.022).

Conclusions

This study showed that adjuvant CRT significantly reduced LRR after D2 dissection of LAGC. Early initiation of adjuvant RT with clinical target volume encompassing a2 and b1 regions of para-aortic lymph nodes is recommended for pN1-3a patients after D2 dissection.
Role of NFAT in Chronic Lymphocytic Leukemia and Other B-Cell Malignancies
Authors: Sana Ilenia , Mantione Maria Elena , Angelillo Piera , Muzio Marta
Published: April 2021

In recent years significant progress has been made in the clinical management of chronic lymphocytic leukemia (CLL) as well as other B-cell malignancies; targeting proximal B-cell receptor signaling molecules such as Bruton Tyrosine Kinase (BTK) and Phosphoinositide 3-kinase (PI3Kδ) has emerged as a successful treatment strategy. Unfortunately, a proportion of patients are still not cured with available therapeutic options, thus efforts devoted to studying and identifying new potential druggable targets are warranted. B-cell receptor stimulation triggers a complex cascade of signaling events that eventually drives the activation of downstream transcription factors including Nuclear Factor of Activated T cells (NFAT). In this review, we summarize the literature on the expression and function of NFAT family members in CLL where NFAT is not only overexpressed but also constitutively activated; NFAT controls B-cell anergy and targeting this molecule using specific inhibitors impacts on CLL cell viability. Next, we extend our analysis on other mature B-cell lymphomas where a distinct pattern of expression and activation of NFAT is reported. We discuss the therapeutic potential of strategies aimed at targeting NFAT in B-cell malignancies not overlooking the fact that NFAT may play additional roles regulating the inflammatory microenvironment.
Nanomaterial Complexes Enriched With Natural Compounds Used in Cancer Therapies: A Perspective for Clinical Application
Authors: Saavedra-Leos María Zenaida , Jordan-Alejandre Euclides , López-Camarillo César , Pozos-Guillen Amaury , Leyva-Porras César , Silva-Cázares Macrina Beatriz
Published: April 2021

Resveratrol and quercetin are natural compounds contained in many foods and beverages. Reports indicate implications for the health of the general population; on the other hand the use of both compounds has interesting results for the treatment of many diseases as cardiovascular affections, diabetes, Alzheimer’s disease, viral and bacterial infections among others. Based on their capacities described as anti-inflammatory, antioxidant, and anti-aging, resveratrol and quercetin showed antiproliferative and anticancer activity specifically in maligned cells. These molecular characteristics trigger the pharmacological repurposing of both compounds and improved its research for treating different cancer types with interesting results at in vitro, in vivo, and clinical trial studies. Meanwhile, the development of different systems of drug release in specific sites as nanomaterials and specifically the nanoparticles, potentiates the personal treatment perspective in conjunct with the actual cancer therapies; regularly invasive and aggressive, the perspective of nanomedicine as higher effective and lower invasive has gained popularity. Knowledge of molecular interactions of resveratrol and quercetin in diseases confirms the evidence of multiple benefits, while the multiple analyses suggested a positive response for the treatment and diagnostics of cancer in different stages, including at metastatic stage. The present work reviews the reports related to the impact of resveratrol and quercetin in cancer treatment and its effects when the antioxidants are encapsulated in different nanoparticle systems, which improve the prospects of cancer treatment.
Red Blood Cell Contribution to Hemostasis
Authors: Gillespie Andrea H. , Doctor Allan
Published: April 2021

Red Blood Cells (RBCs) have been increasingly recognized to play important roles in hemostasis and the mechanisms by which they do so continue to be elucidated. First and foremost, RBC biomechanics are the principal determinant of viscosity and flow dynamics of blood, which strongly influence all features of hemostasis. Of note, morphologic pathology, such as that found in sickle cell disease, leads to increased risk of thrombotic disease. RBC surface interactions govern signaling between platelets and RBCs and also aid in the conversion of prothrombin to thrombin. Additionally, RBCs generate microparticles which have been shown to reduce clotting time. Finally, blood clot structure and maturation are dependent on the inclusion of RBCs in forming thrombi. Here, we review the above mechanisms of RBC contribution to hemostasis.
Electroacupuncture Regularizes Gastric Contraction and Reduces Apoptosis of Interstitial Cells of Cajal in Diabetic Rats
Authors: Wang Hongcai , Zhao Kaile , Shi Ning , Niu Qiong , Liu Chengxia , Chen Yan
Published: April 2021

Background/Aims

Gastric dysmotility is a frequent complication among patients with diabetes mellitus. Electroacupuncture (EA) has been empirically used to relieve gastrointestinal symptoms. The aims of this study were to investigate the effects of EA on gastric contraction and the mechanisms of interstitial cells of Cajal (ICC) involved.

Materials and Methods

Male Sprague–Dawley rats were randomized into the normal control, diabetes (DM), diabetic and sham EA (DM + SEA), diabetic and low-frequency EA (DM + LEA), and diabetic and high-frequency EA (DM + HEA) groups. Diabetic models were established and then treated with EA for 8 weeks. Body weight and blood glucose were recorded every 2 weeks. The spontaneous contractions of distal gastric strips were analyzed. Immunostaining and RT-PCR were used to test the apoptotic ICC, IGF-1/IGF-1R, and Nrf2/HO-1 pathways.

Results

The body weight in the DM + LEA and DM + HEA groups were increased compared with that of the DM group, though there was no effect on the blood glucose. The gastric contractions were obviously disordered in the DM group, but EA could regularize the contractions. The number of apoptotic ICC was dramatically increased in the DM group, but reduced with EA treatment. Meanwhile, the IGF-1/IGF-1R pathway was verified to be significantly altered in diabetic rats. The Nrf2/HO-1 pathway was not significantly increased in the DM group. EA with different frequencies efficiently improved the expression of IGF-1/IGF-1R signaling and activated the Nrf2/HO-1 pathway.

Conclusion

EA could improve gastric motility dysfunction and attenuate ICC apoptosis possibly through the regulation of IGF-1/IGF-1R and Nrf2/HO-1 pathways. EA may be a potential therapeutic method for diabetic gastric motility dysfunction.
Cerebrovascular Reactivity: Purpose, Optimizing Methods, and Limitations to Interpretation – A Personal 20-Year Odyssey of (Re)searching
Authors: Fisher Joseph A. , Mikulis David J.
Published: April 2021

The brain is a neurovascular organ. A stimulus-response approach is effective in interrogating the physiology of its vasculature. Ideally, the stimulus is standardized across patients, and in a single patient over time. We developed a standard stimulus and attempted to measure, classify, and interpret the many forms of responses. Over the past 20 years, our work has delivered nuanced insights into normal cerebral vascular physiology, as well as adaptive physiological responses in the presence of disease. The trajectory of our understanding did not follow a logical linear progression; rather, it emerged as a coalescence of new, old, and previously dismissed, ideas that had accumulated over time. In this essay, we review what we believe were our most valuable – and sometimes controversial insights during our two decades-long journey.
Effects of Whole Body Electrostimulation Associated With Body Weight Training on Functional Capacity and Body Composition in Inactive Older People
Authors: Evangelista Alexandre Lopes , Alonso Angelica Castilho , Ritti-Dias Raphael M. , Barros Bruna Massaroto , Souza Cleison Rodrigues de , Braz Tiago Volpi , Bocalini Danilo Sales , Greve Julia Maria D'andréa
Published: April 2021

Objective: To analyze the effects of whole body electrostimulation (WB-EMS) with body weight training on functional fitness and body composition of older men.

Methods: Twenty physically inactive older men were randomized into: Control group (control), performed the body weight exercise training wearing electrostimulation clothing, but without receiving electrical current stimuli (n = 10), and body weight associated with whole body electrostimulation group (BW+WB-EMS), performed the body weight exercise training wearing electrostimulation clothing plus whole body electrostimulation (n = 10). The training sessions were performed twice a week for 6 weeks and included eight exercises using body weight, performed in two sets of eight repetitions. Physical function was assessed using a battery composed of seven tests, six derived from the Senior fitness test and a handgrip strength test. We also measured the muscle thickness (MT) of the biceps and triceps brachii and vastus lateralis.

Results: The BW+WB-EMS group presented increased (p < 0.05) performance in the 30-s chair stand test (10.2 ± 3.3 vs. 13.8 ± 5.0 reps), arm curl (16.6 ± 3.9 vs. 19.9 ± 6.1 reps), 6-min walk test (402 ± 96 vs. 500 ± 104 m), and handgrip strength test (30 ± 11 vs. 32 ± 11 kgf). The BW+WB-EMS group also presented increased MT (p < 0.05) in the biceps brachii (17.7 ± 3.0 vs. 21.4 ± 3.4 mm), triceps brachial (14.7 ± 3.6 vs. 17.5 ± 4.1 mm), and vastus lateralis muscles (15.1 ± 2.6 vs. 18.6 ± 4.3 mm). Moderate correlations were found in arm curl (p = 0.011, r = 0.552) but not handgrip strength (p = 0.053, r = 0.439) with changes in the biceps MT. Moderate changes in the 6-min walk distance were significantly correlated with changes in vastus lateralis MT (p = 0.036, r = 0.471). There was a moderate correlation between the changes in the 30-s chair stand test (p = 0.006, r = 0.589) and changes in the vastus lateralis MT. Furthermore, although a moderate correlation (r = 0.438) was found between triceps MT and handgrip strength no significant difference (p = 0.053) was reported. Additionally, there were no statistical differences in any parameters for the control group.

Conclusion: WB-EMS with body weight training increased functional fitness and MT in physically inactive older men.
A Reproducible Protocol to Assess Arrhythmia Vulnerability in silico: Pacing at the End of the Effective Refractory Period
Authors: Azzolin Luca , Schuler Steffen , Dössel Olaf , Loewe Axel
Published: April 2021

In both clinical and computational studies, different pacing protocols are used to induce arrhythmia and non-inducibility is often considered as the endpoint of treatment. The need for a standardized methodology is urgent since the choice of the protocol used to induce arrhythmia could lead to contrasting results, e.g., in assessing atrial fibrillation (AF) vulnerabilty. Therefore, we propose a novel method—pacing at the end of the effective refractory period (PEERP)—and compare it to state-of-the-art protocols, such as phase singularity distribution (PSD) and rapid pacing (RP) in a computational study. All methods were tested by pacing from evenly distributed endocardial points at 1 cm inter-point distance in two bi-atrial geometries. Seven different atrial models were implemented: five cases without specific AF-induced remodeling but with decreasing global conduction velocity and two persistent AF cases with an increasing amount of fibrosis resembling different substrate remodeling stages. Compared with PSD and RP, PEERP induced a larger variety of arrhythmia complexity requiring, on average, only 2.7 extra-stimuli and 3 s of simulation time to initiate reentry. Moreover, PEERP and PSD were the protocols which unveiled a larger number of areas vulnerable to sustain stable long living reentries compared to RP. Finally, PEERP can foster standardization and reproducibility, since, in contrast to the other protocols, it is a parameter-free method. Furthermore, we discuss its clinical applicability. We conclude that the choice of the inducing protocol has an influence on both initiation and maintenance of AF and we propose and provide PEERP as a reproducible method to assess arrhythmia vulnerability.
An Emotion Regulation and Impulse Control (ERIC) Intervention for Vulnerable Young People: A Multi-Sectoral Pilot Study
Authors: Hall Kate , Youssef George , Simpson Angela , Sloan Elise , Graeme Liam , Perry Natasha , Moulding Richard , Baker Amanda L. , Beck Alison K. , Staiger Petra K.
Published: April 2021

Objective: There is a demonstrated link between the mental health and substance use comorbidities experienced by young adults, however the vast majority of psychological interventions are disorder specific. Novel psychological approaches that adequately acknowledge the psychosocial complexity and transdiagnostic needs of vulnerable young people are urgently needed. A modular skills-based program for emotion regulation and impulse control (ERIC) addresses this gap. The current one armed open trial was designed to evaluate the impact that 12 weeks exposure to ERIC alongside usual care had on young people's ability to regulate emotions, as well as examine potential moderating mechanisms.

Methods: Seventy nine young people (50.6% male; M = 19.30; SD = 2.94) were enrolled to the 12 week intervention period. Twenty one practitioners from youth and community health services delivered relevant ERIC modules adjunct to usual care. Linear mixed effects regression (with random intercept) was used to examine change over time across the primary outcome of emotion dysregulation and secondary outcomes of depression, anxiety, stress, experiential avoidance and mindfulness. Moderation analyses were conducted to test whether the magnitude of change in emotion dysregulation moderated change over time in secondary outcomes.

Results: Analyses revealed significant improvement in the primary outcome of emotion dysregulation with a moderate effect size (Mean Change = −10.24, 95% CI (−14.41, −6.06; Cohen's dav = −0.53), in addition to decreases in the secondary outcomes of depression, anxiety, stress and experiential avoidance. No improvements in mindfulness were reported. Moderation analyses revealed that the residualised change over time in emotion dysregulation moderated the change over time in symptoms of distress, depression, anxiety, stress, experiential avoidance, and mindfulness.

Conclusion: Reductions in the severity of emotion dysregulation, depression, anxiety, stress and experiential avoidance are promising, and were evident despite the complexity of the participants and the diversity of the service setting. The improvements found in each outcome were only observed for those young people whose emotion regulation also improved, providing preliminary evidence for the role of emotion regulation as a key treatment target in this population.
MAGNITIVE: Effectiveness and Feasibility of a Cognitive Training Program Through Magic Tricks for Children With Attention Deficit and Hyperactivity Disorder. A Second Clinical Trial in Community Settings
Authors: Bonete Saray , Osuna Ángela , Molinero Clara , García-Font Inmaculada
Published: April 2021

Previous studies have explored the impact of magic tricks on different basic cognitive processes yet there is a need of examining effectiveness of a cognitive training program through magic tricks for children with attention deficit hyperactivity disorder (ADHD). The present study examines the effectiveness and feasibility of the MAGNITIVE program, a manualized intervention for cognitive training through the learning of magic tricks. A total of 11 children with ADHD (from 8 to 12 years) participated in separated groups of two different community settings (hospital center and school), and were assessed at pre-treatment, post-treatment, and a 3-month later follow-up in different tasks involving processing speed, sustained attention, selective attention, and mental flexibility. Using non parametric statistical analyses and Reliable Change Index, the results showed that these children receiving MAGNITIVE particularly improved their performance in sustained attention, shifting attention, and mental flexibility, changes were also observed in processing speed performance yet further research is needed in terms of selective attention and inhibition, given the great individual differences within this sample. Changes were maintained when the program was finished. In terms of viability, the study proved a good treatment integrity in different contexts (hospital and school setting), adherence to the curriculum (attendance and some practice at home), and high levels of engagement satisfaction. In this second clinical trial, MAGNITIVE program appears to be a feasible training program for children with ADHD, as an alternative for medication when possible.
Predicting Big Data Adoption in Companies With an Explanatory and Predictive Model
Authors: Villarejo-Ramos Ángel F. , Cabrera-Sánchez Juan-Pedro , Lara-Rubio Juan , Liébana-Cabanillas Francisco
Published: April 2021

The purpose of this paper is to identify the factors that affect the intention to use Big Data Applications in companies. Research into Big Data usage intention and adoption is scarce and much less from the perspective of the use of these techniques in companies. That is why this research focuses on analyzing the adoption of Big Data Applications by companies. Further to a review of the literature, it is proposed to use a UTAUT model as a starting model with the update and incorporation of other variables such as resistance to use and perceived risk, and then to perform a neural network to predict this adoption. With respect to this non-parametric technique, we found that the multilayer perceptron model (MLP) for the use of Big Data Applications in companies obtains higher AUC values, and a better confusion matrix. This paper is a pioneering study using this hybrid methodology on the intention to use Big Data Applications. The result of this research has important implications for the theory and practice of adopting Big Data Applications.
There Is More to Mindfulness Than Emotion Regulation: A Study on Brain Structural Networks
Authors: Baltruschat Sabina , Cándido Antonio , Maldonado Antonio , Verdejo-Lucas Carmen , Catena-Verdejo Elvira , Catena Andrés
Published: April 2021

Dispositional mindfulness and emotion regulation are two psychological constructs closely interrelated, and both appear to improve with the long-term practice of mindfulness meditation. These constructs appear to be related to subcortical, prefrontal, and posterior brain areas involved in emotional processing, cognitive control, self-awareness, and mind wandering. However, no studies have yet discerned the neural basis of dispositional mindfulness that are minimally associated with emotion regulation. In the present study, we use a novel brain structural network analysis approach to study the relationship between structural networks and dispositional mindfulness, measured with two different and widely used instruments [Mindfulness Attention Awareness Scale (MAAS) and Five Facet Mindfulness Questionnaire (FFMQ)], taking into account the effect of emotion regulation difficulties. We observed a number of different brain regions associated with the different scales and dimensions. The total score of FFMQ and MAAS overlap with the bilateral parahippocampal and fusiform gyri. Additionally, MAAS scores were related to the bilateral hippocampus and the FFMQ total score to the right insula and bilateral amygdala. These results indicate that, depending on the instrument used, the characteristics measured could differ and could also involve different brain systems. However, it seems that brain areas related to emotional reactivity and semantic processing are generally related to Dispositional or trait mindfulness (DM), regardless of the instrument used.
Audio Described vs. Audiovisual Porn: Cortisol, Heart Rate and Engagement in Visually Impaired vs. Sighted Participants
Authors: Rojo López Ana M , Ramos Caro Marina , Espín López Laura
Published: April 2021

Audio description remains the cornerstone of accessibility for visually impaired audiences to all sorts of audiovisual content, including porn. Existing work points to the efficacy of audio description to guarantee immersion and emotional engagement, but evidence on its role in sexual arousal and engagement in porn is still scant. The present study takes on this challenge by comparing sighted and visually impaired participants’ experiences with porn in terms of their physiological response [i.e., cortisol and heart rate (HR)] and self-report measures of affect [Positive and Negative Affect Schedule (PANAS); Watson et al., 1988], anxiety [State-Trait Anxiety Inventory (STAI); Spielberger et al., 1970], sexual reactivity and arousal [Sexual Inhibition/Sexual Excitation Scale (SIS/SES); Moyano and Sierra (2014); and the Ratings of Sexual Arousal (RSA); Mosher (2011)], and narrative engagement or transportation [The Transport Narrative Questionnaire, Green and Brock (2013)]. 69 Spanish participants were allocated into three different groups: 25 sighted participants who watched and heard the porn scenes in their audio-visual version (AV); 22 sighted participants who listened to the audio described version without images (AD); and 22 visually impaired participants who also listened to the audio described version without images (ONCE). Overall, results on physiological and self-report measures revealed no significant differences between groups or different versions of the clips. The analysis of cortisol reactivity to porn as the maximum increase or decrease in cortisol (t+12) with respect to baseline values (t−20) revealed no significant differences between the groups, but pointed to a higher percentage of non-responders than responders in the three groups, the highest being found in the ONCE group. As for participants’ cardiac response to the clips, no significant differences were found across the groups, with the highest HR levels being registered in the baseline phase. Self-report measures revealed significant between-group differences in negative affect. The ONCE group displayed the highest pre-task levels of negative affect and was the only group that showed a decrease in negative affect after exposure to the clips. Sighted and visually impaired participants reported to be moderately aroused and immersed in the films, regardless of exposure to AV or AD porn. In addition, correlations found between participants’ levels of self-report sexual arousal and transportation and post-task affect pointed to a positive relationship between exposure to porn and perceived levels of sexual arousal and affect. Results from the study reflected the efficacy of audio description in providing sighted and visually impaired audiences with a similar experience to that offered by original AV porn scenes. This study is exploratory but provides valid, initial groundwork for further research on the impact of audio description on porn reception.
Cultural Adaptation of Community Informant Tool for Detection of Maternal Depression in Rural Pakistan
Authors: Mohsin Shamaila , Atif Najia , Rabbani Waqas , Tariq Ahmaren , Khan Shahzad Ali , Tariq Mahjabeen , Sikander Siham
Published: April 2021

Background: Evidence indicates that mental health issues like depression, epilepsy, and substance misuse can be detected with reasonable accuracy in resource-poor settings. The Community Informant Detection Tool (CIDT) is one such approach used for detecting mental health problems, including depression. We adapted this community informant approach for detecting maternal depression in Pakistan.

Methods: Adaptation of Community Informant Detection Tool for Maternal Depression (CIDT-MD) involved five steps. First, a scoping review of the literature was conducted to select an appropriate tool for adaptation. Second, in-depth interviews were conducted to explore the idioms of depression and distress, perceived causes, and the effects of maternal depression among currently depressed and recovered mothers (n = 11), mothers in law (n = 6), and Primary Care Providers (Primary Care Physicians and Lady Health Supervisors) (n = 6). Third, case vignettes and illustrations were created with input from a panel of mental health experts, incorporating the idioms of depression and distress used, causes, and effects for each symptom described. Fourth, to assess the comprehensibility of the illustrations and level of understanding, Focus Group Discussions (n = 4) were done with purposely selected community health workers (Lady Health Workers and Lay Peers, n = 28) trained in delivering maternal depression intervention. The final step was reflection and inputs by a panel of mental health experts on all steps to finalize the content of the tool.

Results: Context-specific cultural adaptation in the presentation and format of CIDT-MD was conducted successfully. Lady Health Workers (LHW) and Lay Peers (LP) were found to be the most appropriate persons to use the tool and function as the informants. The adapted tool with all its vignettes and illustrations was found to be easily understandable, comprehensible, and culturally appropriate, meaningful, and contextually relevant by the community health workers and peers working in the relevant settings. They easily relate to and identify potentially depressed such women lining up with the tool. Lastly, the coding of the tool was found easy to follow as well.

Conclusion: The Community Informant Detection Tool for Maternal Depression (CIDT-MD) is a culturally acceptable, easy to use, and comprehensible tool for detecting maternal depression in community settings of Pakistan. The community informants found the content and approach highly relevant to the local needs.
Posttraumatic Stress Symptoms, Quality of Life, and Stress Burden in Caregivers of Patients With Severe Mental Illness: An Underestimated Health Concern
Authors: Rady Ahmed , Mouloukheya Tarek , Gamal Eman
Published: April 2021

Caregivers of patients with severe mental disorders experience a heavy stress burden that can manifest as psychiatric symptoms mimicking posttraumatic stress disorder (PTSD) and can negatively impact interpersonal relationships and work performance. The present study investigated the prevalence of PTSD symptoms, quality of life (QoL), and stress burden in caregivers of patients with severe mental illness. A total of 70 caregivers of severely mentally ill patients and 70 control subjects who were caregivers of patients with a chronic debilitating medical illness (cardiovascular disease) were recruited from university hospital outpatient facilities. Severe mental illness was defined based on a Global Assessment of Functioning score <50 and duration of illness >2 years. Both groups were evaluated with the Zarit Burden interview, a QoL questionnaire, and Posttraumatic Diagnostic Scale (PDS). The results showed that 37.14% (n = 26) of caregivers of patients with severe mental illness showed PTS symptoms compared to 0% of caregivers of patients with physical illness, and 15.17% (n = 11) met the diagnostic criteria for PTSD. Caregivers of patients with severe mental illness had higher stress burden and lower QoL scores than the control group (p < 0.05). These results indicate that caregivers of patients with severe mental illness have a high stress burden that may lead to PTSD, highlighting the importance of providing psychological support to this group.
Spiritual Well-Being and Mental Health During the COVID-19 Pandemic in Italy
Authors: Coppola Ilaria , Rania Nadia , Parisi Rosa , Lagomarsino Francesca
Published: April 2021

During the COVID-19 pandemic in Italy, people and families experienced a new and sudden situation that forced them to stay in their homes for a long period (February 25- May 26). In this context, many people found themselves in great difficulty, not only because of the fear of contagion or the economic problems deriving from the closure of production activities but also because the virus profoundly changed the way of life in society. The “Social distancing” concept became central in all personal relationships, including close family relationships. In this situation, our paper seeks to understand the role of spirituality and religiosity in reacting to this difficult situation and in particular on the physical and psychological health of the people involved. The data we present here are part of a multidisciplinary research with a quantitative theoretical framework. As the data was collected during the first Italian lockdown, a total of 1,250 adults from all over Italy participated in the on-line questionnaire. Among the main results it emerged that the participants perceived lower levels of spiritual well-being and mental health than the pre-pandemic situation with a significant gender difference; in fact, women perceived lower mental health than men. At the same time, it is evident that spirituality and religious practices are a protective factor connected not only with psychological and mental but also physical health. Finally, it appears evident that the family is a protective factor with respect to mental health, even in a period so full of stress factors, those who did not live alone and especially those who had to take care of small children reported higher perceived mental health and a greater ability to activate coping resources.
Case Report: Hidden Oral Squamous Cell Carcinoma in Oral Somatic Symptom Disorder
Authors: Suga Takayuki , Tu Trang Thi Huyen , Takenoshita Miho , Mikuzuki Lou , Umezaki Yojiro , Shimamoto Hiroaki , Michi Yasuyuki , Hong Chaoli , Abiko Yoshihiro , Ikeda Tohru , Uzawa Narikazu , Harada Hiroyuki , Toyofuku Akira
Published: April 2021

Background: Burning mouth syndrome (BMS) is a common condition of predominant oral pain without evident cause, that maxillofacial surgeons and otolaryngologists often refer to psychiatrists as somatic symptom disorder. In very rare cases, its typical burning symptom mimics those of other diseases in which serious fatal comorbidities may be missed. We encountered three rare cases of oral squamous cell carcinoma (OSCC) with the first symptom of burning tongue.

Case Presentation: Case 1: A 68-year-old woman had burning pain on the left lingual margin for 8 years. Antidepressant treatment was not efficacious. Cytology and biopsy revealed OSCC. Case 2: A 70-year-old man had burning sensation and paralysis of the tongue for 6 months. Magnetic resonance imaging (MRI) revealed a 37 × 23-mm mass under the floor of the mouth and enlargement of lymph nodes on both sides. Case 3: A 90-year-old man had burning sensation of the tongue for 1 year. MRI revealed a 12 × 12-mm mass on the mandible with bone absorption.

Conclusion: This case series suggests that psychiatrists must always be careful in regarding BMS as somatic symptom disorder and be cautious of the possibility of OSCC, especially in elderly patients.
Perceived Stress in a Gender Perspective: A Survey in a Population of Unemployed Subjects of Southern Italy
Authors: Costa Chiara , Briguglio Giusi , Mondello Stefania , Teodoro Michele , Pollicino Manuela , Canalella Andrea , Verduci Francesca , Italia Sebastiano , Fenga Concettina
Published: April 2021

Stressful life events, are differently handled by women and men. This study evaluates gender differences in perceived stress and health status among a sample of subjects going through a transition period from unemployment to work. This cross-sectional study enrolled 395 participants, 245 men (62%) and 150 (38%) women, between 19 and 67 years, that were going to be hired for a 6-month contract. Before being employed, all participants underwent a mandatory protocol consisting in a general medical check. Stress assessment was performed by using the Perceived Stress Scale (PSS). Most of the participants (68%) showed normal to low perceived stress level. But dividing the sample by gender, out of the remaining 32% with medium to high stress level, 11% male subjects and 22.7% females reported high perceived stress values. We found mean PSS values that are overlapping with those in the general population of developed countries. This study does not suggest an association between perceived stress and health or social parameters. However, our results highlight that the female gender is associated with higher stress level, pointing out the relevance of specific and designed interventions in the context of health promotion programs, especially in order to mitigate stress in more susceptible subjects.
Food/Non-Food Classification of Real-Life Egocentric Images in Low- and Middle-Income Countries Based on Image Tagging Features
Authors: Chen Guangzong , Jia Wenyan , Zhao Yifan , Mao Zhi-Hong , Lo Benny , Anderson Alex K. , Frost Gary , Jobarteh Modou L. , McCrory Megan A. , Sazonov Edward , Steiner-Asiedu Matilda , Ansong Richard S. , Baranowski Thomas , Burke Lora , Sun Mingui
Published: April 2021

Malnutrition, including both undernutrition and obesity, is a significant problem in low- and middle-income countries (LMICs). In order to study malnutrition and develop effective intervention strategies, it is crucial to evaluate nutritional status in LMICs at the individual, household, and community levels. In a multinational research project supported by the Bill & Melinda Gates Foundation, we have been using a wearable technology to conduct objective dietary assessment in sub-Saharan Africa. Our assessment includes multiple diet-related activities in urban and rural families, including food sources (e.g., shopping, harvesting, and gathering), preservation/storage, preparation, cooking, and consumption (e.g., portion size and nutrition analysis). Our wearable device (“eButton” worn on the chest) acquires real-life images automatically during wake hours at preset time intervals. The recorded images, in amounts of tens of thousands per day, are post-processed to obtain the information of interest. Although we expect future Artificial Intelligence (AI) technology to extract the information automatically, at present we utilize AI to separate the acquired images into two binary classes: images with (Class 1) and without (Class 0) edible items. As a result, researchers need only to study Class-1 images, reducing their workload significantly. In this paper, we present a composite machine learning method to perform this classification, meeting the specific challenges of high complexity and diversity in the real-world LMIC data. Our method consists of a deep neural network (DNN) and a shallow learning network (SLN) connected by a novel probabilistic network interface layer. After presenting the details of our method, an image dataset acquired from Ghana is utilized to train and evaluate the machine learning system. Our comparative experiment indicates that the new composite method performs better than the conventional deep learning method assessed by integrated measures of sensitivity, specificity, and burden index, as indicated by the Receiver Operating Characteristic (ROC) curve.
OUTPUT: Choreographed and Reconfigured Human and Industrial Robot Bodies Across Artistic Modalities
Authors: Cuan Catie
Published: April 2021

Millions of industrial robots are used across manufacturing and research applications worldwide. Handfuls of these robots have been used in dance, installation, and theatrical art works as tools and performers.OUTPUT, a collaborative artwork presented here, employs an industrial robot as choreographic source material and dancing body in order to reframe these robots as performers and bring them into closer proximity with the general public. ThisOUTPUTwork has existed as a performance, installation, and augmented reality application. All three formats of the work include improvisational components, where a human can dance with a representation of themselves alongside an industrial robot, facilitating an embodied and creative experience next to these sequestered machines.
Air Quality Measurements and Education: Improving Environmental Awareness of High School Students
Authors: Höfner Sebastian , Schütze Andreas
Published: April 2021

Indoor air quality (IAQ) has gained renewed importance in public awareness, especially in times of the corona pandemic. In classrooms in particular, regular ventilation is essential to keep the potential viral load in the air as low as possible and thus reduce the likelihood of infection with the corona virus. But also the concentration of other pollutants, such as particulate matter (PM) or volatile organic compounds (VOCs), which are responsible for symptoms such as concentration disorders, headaches and dizziness can be reduced. In addition to the direct measurement of VOC pollutants using metal oxide semiconductor (MOS) gas sensors, CO2is also measured as an indicator gas for monitoring IAQ. However, young people in particular have only a diffuse idea of air pollutants. This can be explained by the fact that many of these air pollutants are both odorless and colorless and are only detectable using suitable sensors. In order to provide students with a comprehensive picture of the topic of air quality and thus strengthen their environmental awareness, declarative, conceptual and procedural knowledge needs to be combined. This includes knowledge about different sensor principles, pollutant types, their limits, health effects on humans and strategies to maintain good air quality, both indoors and outdoors. To ensure that this knowledge does not remain inert, authentic learning scenarios with a direct relevance to everyday life must be provided. Measuring pollutants in indoor air in particular offers the opportunity to apply what has been learned in a context-oriented manner. By linking the performance of measurements with sensors and the subsequent interpretation of measurement results, environmental awareness can be sharpened with regard to IAQ. This can be achieved by measuring pollutants with sensors and then interpreting and classifying the measurement results. In this paper, various student experiments with gas sensors are presented that introduce the function principles of different sensor types, record air quality data and provide meaningful interpretation. Based on these experiences, students are encouraged to develop their own research questions on air quality.
An Experimental Investigation of the Convective Heat Transfer on a Small Helicopter Rotor with Anti-Icing and De-Icing Test Setups
Authors: Samad Abdallah , Villeneuve Eric , Blackburn Caroline , Morency François , Volat Christophe
Published: April 2021

Successful icing/de-icing simulations for rotorcraft require a good prediction of the convective heat transfer on the blade’s surface. Rotorcraft icing is an unwanted phenomenon that is known to cause flight cancelations, loss of rotor performance and severe vibrations that may have disastrous and deadly consequences. Following a series of experiments carried out at the Anti-icing Materials International Laboratory (AMIL), this paper provides heat transfer measurements on heated rotor blades, under both the anti-icing and de-icing modes in terms of the Nusselt Number (Nu). The objective is to develop correlations for the Nu in the presence of (1) an ice layer on the blades (NuIce) and (2) liquid water content (LWC) in the freestream with no ice (NuWet). For the sake of comparison, the NuWet and the NuIce are compared to heat transfer values in dry runs (NuDry). Measurements are reported on the nose of the blade-leading edge, for three rotor speeds (Ω) = 500, 900 and 1000 RPM; a pitch angle (θ) = 6°; and three different radial positions (r/R), r/R = 0.6, 0.75 and 0.95. The de-icing tests are performed twice, once for a glaze ice accretion and another time for rime ice. Results indicate that the NuDry and the NuWet directly increased with V∝, r/R or Ω, mainly due to an increase in the Reynolds number (Re). Measurements indicate that the NuWet to NuDry ratio was always larger than 1 as a direct result of the water spray addition. NuIce behavior was different and was largely affected by the ice thickness (tice) on the blade. However, the ice acted as insulation on the blade surface and the NuIce to NuDry ratio was always less than 1, thus minimizing the effect of convection. Four correlations are then proposed for the NuDry, the NuWet and the NuIce, with an average error between 3.61% and 12.41%. The NuDry correlation satisfies what is expected from heat transfer near the leading edge of an airfoil, where the NuDry correlates well with Re0.52.
Relationship between Antioxidant Components and Oxidative Stability of Peanut Oils as Affected by Roasting Temperatures
Authors: Ciou Jhih-Ying , Chen Hsin-Chun , Chen Chih-Wei , Yang Kai-Min
Published: April 2021

The study sought to investigate the effect of roasting temperatures on antioxidant components and oxidative stability of peanut oils. The total phenolic content, total flavonoid content, α–tocopherol content, and phytosterol content in peanut oils was influenced by roasting at temperatures of 120 °C, 140 °C, and 160 °C, while those roasting temperatures had no effect on the fatty acid profile and γ–tocopherol content of peanut oils. Roasting promotes the quality of peanut oil aroma via the Maillard reaction, particularly when it is derived from N–heterocyclic compounds (such as pyrazine and pyrrole). The oxidative stability of peanut oils was investigated using the Rancimat method, and the results show that there is a linear relationship between roasting and natural logarithm of the induction period (R2: 0.959~0.998). This was determined based on the Arrhenius equation, which indicated the activation energy (Ea) was in the range of 82.08~108.61 kJ/mol. In principal component analysis (PCA) analysis, the antioxidant stability of the increase levels of phenols released in the peanut oils was found to rise with the increment of roasting temperatures. The data obtained in this study should be confirmed as the nutritional benefits of peanut oils that will be most appealing to consumers.
Effects of Nitrogen Application Rate on Protein Components and Yield of Low-Gluten Rice
Authors: Lan Yan , Sui Xiaodong , Wang Jin , Duan Qiang , Wu Chaoyue , Ding Chunbang , Li Tian
Published: April 2021

Low-gluten rice cultivar D105 was grown in the field under five nitrogen (N) treatments (N0: 0, N90: 90, N135: 135, N180: 180, and N225: 225 kg·hm−2) to investigate the effect of N application rate on the yield and the resulting dynamic changes in protein content, grain processing quality, and relative content of each component protein. The results indicated that the number of effective panicles, seed setting rate, the number of solid grains, dry matter, leaf nitrate reductase and glutamine synthetase activities, and yield increased with N application rate ranging from 0 to 180 kg·hm−2. However, the seed setting rate and the number of solid grains decreased under N225 treatment, leading to a decline in yield. At maturity, 35 days after flowering, no significant differences between albumin and gliadin in the rice grain were found among the N treatments, while globulin and gluten differed among treatments, indicating that the effect of N application rate on the former was slightly the opposite to that observed on the latter. Further, the N application rates did not change the proportions of component proteins relative to the total protein content in the grain. Processing and taste qualities of D105 low-gluten rice were optimal in the N135 and N180 treatments, and the overall rice quality decreased under the N225 treatment. Therefore, the optimal N application rate for yield and processing quality of D105 low-gluten rice is N180: 180 kg·hm−2.
A Biotreatment Effect on Dynamics of Cattle Manure Composition and Reduction of Ammonia Emissions from Agriculture
Authors: Naujokienė Vilma , Bagdonienė Indrė , Bleizgys Rolandas , Rubežius Mantas
Published: April 2021

Increasing control of localized air pollution caused by ammonia is identified, including limiting the maximum emissions from agriculture. In EU countries, the agricultural sector is the source of above 94% of the total anthropogenic emissions of ammonia, of which manure removal systems account for 56%. In view of the reason for the agricultural waste management by formation and propagation of ammonia gas—the bacterial and enzymatic degradation of organic components in excrement—it is important to evaluate the effect of biotreatment of 100% natural composition (contain Azospirillum sp. (N) (number of bacterial colonies −1 × 109 cm−3), Frateuria aurentia (K) (number of bacterial colonies −1 × 109 cm−3), Bacillus megaterium (P) (bacterial colony count −1 × 109 cm−3), seaweed extract (10% by volume), phytohormones, auxins, cytokinin, gibberellins, amino acids, and vitamins) on the emission of ammonia from organic waste. Experimental research was carried out to determine significant differences of dynamics in agrochemical composition of manure, NH3 gas emissions, depending on biotreatment, manure storage duration, and ventilation intensity of the barn. Gas emission was obtained via laser gas analyzer using a spectroscopic method in a specially reconstructed wind tunnel chamber. About 32% manure biotreatment effect on reduction of ammonia emissions was established. The maximum effect of the biodegradable compound on gaseous propagation was assessed after 28–35 days of manure storage and proved all biotreatment effect time of 49–56 days. By the saving nitrogen loses priority, manure biotreatment could reduce nitrogen losses from manure and inorganic N fertilizers by approximately 5%, also could reduce approximately 5911.1 thousand tones nitrogen fertilizer in the world and reduce approximately 5.5 Eur ha−1. “The biotreatment impact assessment confirmed that proper application of biotreatment can reduce ammonia emissions from manure and environmental pollution from agriculture”.