bluuebunny/crossref_metadata_2025 huggingface dataset:
Data resource profile: the disability statistics questionnaire review database (DS-QR Database): a database of population censuses and household surveys with internationally comparable disability questions
Authors: Carpenter Bradley , Kamalakannan Sureshkumar , Saikam Pavani , Alvarez David Vicente , Hanass-Hancock Jill , Murthy GVS , Pinilla-Roncancio Monica , Rivas Velarde Minerva , Teodoro Douglas , Mitra Sophie
Published: December 2024

IntroductionThe 2030 Sustainable Development Agenda and the United Nations Convention on the Rights of Persons with Disabilities (CRPD) aspire to leave no one behind and call for the inclusion of persons with disabilities in all spheres of life. To monitor this goal of inclusion, CRPD's Article 31 requires state parties to collect data about the situation of persons with disabilities. The Disability Statistics -- Questionnaire Review Database (DS-QR Database) reports on whether population and housing censuses and household surveys include internationally recommended disability questions for adults ages 15 and older.
MethodsThe Disability Data Initiative (DDI), an international consortium of researchers, regularly retrieves and analyses a list of surveys and censuses from international catalogs, libraries and websites of national statistics offices. Questionnaires are reviewed to identify if they include internationally recommended questions on functional difficulties (e.g. difficulty seeing), more specifically (i) the Washington Group Short Set (WG-SS) or (ii) questions that meet at least the United Nations 2017 guidelines for disability measurement in censuses (other functional difficulty questions thereafter).
ResultsThe DS-QR Database includes the review results for the questionnaires of 3027 population censuses and surveys from 199 countries and territories collected from 2009 to 2023. The review has information on whether each dataset has the WG-SS or other functional difficulty questions and overall results per country, region, type of dataset and over time.
ConclusionBy identifying countries that collect internationally comparable disability data, the DS-QR Database can help researchers, policymakers and advocates determine whether countries fulfill their obligations as per CRPD Article 31. It can also assist in identifying which datasets use functional difficulty questions and can be used to research and monitor disability rights over time and across countries. The DS-QR Database is in a Supplementary file and will be accessible on a website upon publication of this article.
Medición de la innovación no tecnológica en empresas del sector mármol del Estado de Puebla, utilizando PLS-SEM
Authors: García Mota Sandra , Mayett Moreno Yésica , Olivares-Benítez Elías , Kurezyn Díaz Crishelen
Published: December 2024

El principal objetivo de la investigación fue analizar elementos de la innovación no tecnológica, priorizando las variables de los beneficios y los sacrificios entre las empresas dedicadas al mármol y los clientes finales, con el propósito de determinar su grado de satisfacción y lealtad, para ello se realizó una investigación cuantitativa, no experimental de tipo transversal en la que se aplicaron 76 encuestas in situ en los municipios de Tecali de Herrera y Tepeaca, en el estado de Puebla. La recolección de datos se llevó a cabo durante el periodo de enero a marzo del 2024. Se utilizó la técnica PLS-SEM (Partial Least Squares Structural Equation Modeling, por sus siglas en inglés), los datos recabados fueron modelados en el software Smart PLS (versión 3.3.2). Los resultados demostraron una buena capacidad predictiva del modelo de investigación, se detectó un alto grado de correlación entre las variables de satisfacción del cliente y la lealtad a las empresas, de igual forma se demostró que la relación entre los beneficios y los sacrificios influyen en la satisfacción de los clientes. Los hallazgos revelaron que las estimaciones obtenidas para el modelo tienen un impacto significativo en la lealtad de los clientes. Los resultados de este estudio serán útiles para que los dueños de las empresas pueden generar estrategias competitivas. De manera adicional, se recomienda extender este estudio en otras regiones del estado añadiendo nuevas variables.
Developing Sustainable Competitive Advantage: The Role of Dynamic Capability and Innovation Performance in Excelsa Coffee Bean Industry
Authors: Artika Siti , Toiba Hery , Andriani Dwi Retno
Published: December 2024

This study examines the influence of sensing ability, seizing ability, reconfiguring capability, and innovation performance on sustainable competitive advantage (SCA) of the Excelsa Coffee Bean Processing Industry in Bojonegoro. Data was collected through questionnaires that have been tested for validity and reliability. The data analysis uses Structural Equation Modeling (SEM) with SmartPLS software. The results show that these four variables have a positive and significant influence on SCA. Sensing ability plays a role in detecting market changes, while seizing ability allows companies to take advantage of existing opportunities. Reconfiguring capability helps companies adjust resources to stay competitive, and innovation performance is a key factor in creating new ideas that are relevant to the market. The study also found that innovation performance mediates the influence of sensing ability and seizing ability on SCA, making it a key catalyst in turning market potential into competitive advantage. This finding has important implications for the industry, namely the need to improve sensing, seizing, reconfiguring, and innovation performance. Stakeholders, such as local governments and supporting institutions, are also expected to play a role in helping the industry through policies that support this capacity building. Keywords: Performance innovation, Reconfiguring capabilities, Seizing ability, Sensing ability, Sustainable competitive advantage.
Artificial Intelligence Tools in Developing English Writing Skills: Bangladeshi University EFL Students’ Perceptions
Authors: Khan Afrida Lubaba , Hasan Md Mahadhi , Islam Md Nakibul , Uddin Md Sharif
Published: December 2024

Artificial intelligence technologies are advancing rapidly, and this advancement has led to the infiltration of AI tools in various educational sectors worldwide, influencing teaching methodologies and learning experiences. Bangladeshi tertiary-level EFL students, due to the educational and technological landscape in Bangladesh, face unique challenges and diverse perceptions. This study aims to address the gap in factual investigations concerning the effectiveness and acceptance of AI tools among Bangladeshi tertiary-level EFL students. While previous studies focused on language learning at a general level, limited attention has been given to the usability of AI in improving writing skills, particularly in the Bangladeshi context. Therefore, this study explores Bangladeshi tertiary-level EFL students’ perceptions regarding the usage, challenges, and accessibility of AI tools in developing their writing skills. The study employs a mixed-method approach. Specifically, a sequential mixed method, combining both quantitative (survey with 70 participants) and qualitative (in-depth interviews with 10 participants) methods to comprehensively analyze students’ attitudes and experiences. The findings reveal that AI tools have various effects on students’ English writing skills, with strong support for AI as an invaluable educational resource. However, barriers such as technical issues, the potential for plagiarism, prevalent misconceptions, and the need for critical thinking skills were also identified. The study contributes to the ongoing discourse of AI integration in language learning, providing insights into how AI tools can complement, rather than replace, traditional learning methods.
Pendampingan Pemanfaatan Sosial Media Untuk Penyebaran Informasi Pada Dinas Pertanian Lombok Tengah
Authors: Rohati Rohati , Asyari Hasyim , Ashari Maulana
Published: December 2024

Dinas Pertanian kabupaten Lombok Tengah berencana untuk memanfaatkan era keterbukaan informasi dan branding untuk melakukan berbagai inovasi salah satunya yaitu pengembangan Sosial Media sebagai sarana transfer informasi, edukasi, dan komunikasi kepada para petani setempat. untuk mendukung program tersebut maka perlu kiranya diadakan pendampingan untuk mengoptimalkan pemanfaatan media sosial sebagai sarana distribusi informasi kepada msyarakat. kegiatan pendampingan ini dilaksanakan dalam beberapa tahapan yaitu : Analisis Kebutuhan, Pelaksanaan Pendampingan, Evaluasi, dan Laporan. Kegiatan pendampingan pemanfaatan sosial media ini dinilai sangat berhasil, hal ini dilihat dari tingginya respon positif masyarakat Lombok Tengah terutama petani melalui media sosial yang telah dibuat dan dioptimalkan serta diharapkan agar sosial media yang telah ada untuk terus berbagi informasi penting dan terkini sehingga tidak ada lagi masyarakat yang ketinggalan informasi
PENGEMBANGAN MEDIA MADUPLING BERBASIS GOOGLE SITES PADA MATERI MAKHLUK HIDUP DAN LINGKUNGANNYA KELAS II SD
Authors: Aghniya Hawa Zahra
Published: December 2024

This research aims to determine the feasibility of using Google Sites-based Madupling media on living things and their environment in class II elementary school. Madupling media is a website-based learning media which contains material and quizzes. The method used in this research is the Research and Development (R&D) method by applying the ADDIE model (analyze, design, development, implementation and evaluation). Maduplimg media based on Google sites was validated by material and media experts by obtaining i-CVI and s-CVI values of 1 indicating high suitability both in terms of material and media, so that this media was declared suitable for use. Then, this media was tested on 30 grade II elementary school students in Cibeureum II, Sumedang Regency, who gave a final SUS score of 91, indicating the excellent category or having a high level of usefulness. Thus, it can be concluded that the Madupling media based on Google Sites has been proven valid and suitable for use in learning material about living things and their environment in class II elementary school.
IMPLEMENTASI MODEL PBL BERBANTUAN MEDIA INTERAKTIF WORDWALL UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA PADA MATERI BALOK DAN KUBUS KELAS IV
Authors: Lestari Fitri
Published: December 2024

To improve student learning outcomes, teachers should produce interesting Learning materials, such as interactive wordwall games, in response to the rapid advancements in technology during the 4.0 era. The objective of this research is to investigate strategies for enhancing the mathematical proficiency of fourth-grade students via the use of blocks and cubes. A total of 27 students from SDN Palebon 03 Semarang were included in this research, which used Classroom Action Research (PTK). PTK, or classroom action research, consists of two distinct stages. The researchers saw substantial gains in all areas when they used wordwall interactive media. The completion percentage for Cycle II was 92.59%, which is an increase over the 62.96% completion rate in Cycle I. Wordwall interactive media may enhance the learning outcomes of fourth graders in elementary school.
Future Labour Market Prospects of Youth Not in Employment, Education or Training (NEET)
Authors: Dinku Yonatan
Published: December 2024

The 2016 Australian census data showed that one in 10 Australians aged 15-24 years was not in education, employment or training (NEET). The assumption that NEET harms wellbeing underpins theoretical and policy discourses on youth disengagement from work and study. However, despite the extensive literature on the profiles of Australian NEET youth, the evidence on the consequences of NEET for future labour force participation and career progression is limited. Using data from the Australian Census Longitudinal Dataset, this study shows that a spell of NEET at ages 15-24 years is significantly associated with reduced full-time employment prospects and increased risks of being out of the labour force at ages 25-34 years. Even if NEETs find a job later in life, they are more likely to end up in low-skilled occupations. Our findings highlight the importance of distinguishing between full-time and part-time employment while measuring long-term impacts of NEET status. We also showed that some NEETs face higher future labour market risks than others.
Локальні майже-кільця з адитивною групою порядку 128
Authors: Раєвська І. Ю.
Published: December 2024

Визначення скінченних неабелевих p-груп, які є адитивними групами локальних
майже-кілець, є відкритою проблемою (Feigelstock, 2006). Тому важливо визначити такі
групи та класифікувати деякі класи майже-кілець з одиницею на цих групах, наприклад,
локальні майже-кільця. В статті ми досліджуємо локальні майже-кільця на 2-породжених
групах порядку 128.
Modern Structure of State Power: Systemic Analysis of Pros and Cons for National Viability
Authors:   University of World Civilizations named after V.V. Zhirinovsky, Likhonosov Alexander G. , Vasetsky Nikolai A. ,   University of World Civilizations named after V.V. Zhirinovsky, Pivovarov Yuri F. ,   Scientific Research Institute (Military History), Military Academy of the General Staff  of the Armed Forces of the Russian Federation
Published: December 2024

The study presents the results of an analysis of the structure of state power and its role in ensuring the country’s resilience. The fundamental principles of the separation of powers are elucidated, along with the systemic errors inherent in governance associated with a particular power structure. Сonclusion dwells upon the fact of the existing power structures in the states of the world and how the modern information society contributes to the control of the activities of the state. The analysis of the structure of power, its form, constituent elements, relations and expediency is the most important method and the main factor for justifying the need for state-building, development, forecasting and improvement of the state system as a whole. The synthesis of the elements of power and the connections between them, with a certain expediency, gives the entire political system a new increment of necessary properties. The use of a systematic approach makes it possible to develop algorithms for political models that are well formalized and embedded in machine programs, i. e. programmed. This approach also provides the capability to construct political models that are free from utopian dogmas, employing genuinely “cold calculations”, rational justifications, and devoid of human frailties.
Assessment of Efficiency of the Main Types of International Cooperation in the Field of Nuclear Energy
Authors:   Financial University under the Government of the Russian Federation, Ivanov Stanislav Yu.
Published: December 2024

The relevance of the problem under study is due to the development of nuclear energy in the world and the need for international cooperation to find new areas of growth and development. Currently, the development of nuclear energy within one country is not possible, as it requires not only significant investments for the implementation of projects, but also continuous improvement of technologies to achieve the required level of safety and environmental friendliness of production. In this regard, international cooperation is relevant both for the leading countries of the industry, able to participate in the exchange of experience and carry out their activities abroad, and for countries in which nuclear energy is only at the stage of formation, by providing their territory and labor. The author considers the main types of international cooperation in the field of nuclear energy, the effectiveness of participation in them by the leading countries of the nuclear industry. The article is aimed at determining the economic efficiency of the main types of international cooperation and their ordering according to the degree of effectiveness. To achieve this goal, an assessment of the economic efficiency of each of the main types of international cooperation was carried out and economic results were calculated using the example of real projects. The materials of the article can be used to justify the choice of the most effective type of international cooperation by nuclear corporations, as well as in research work on the problems of improving the efficiency of international activities of companies.
Comparative Study of Emotional Attitude Manifestation in the Digital Environment and Reality (Using the Example of Ageism)
Authors:   Pyatigorsk State University, Shapovalova Margarita L. , Miroshnichenko Alina V. ,   Pyatigorsk State University
Published: December 2024

This article presents a new look at the organization and methodology of the study of individuality and its emotional components in the digital environment. An example of the study is the analysis of the manifestation of ageism and emotional attitude towards the elderly in the social network Vkontakte and in real life. The upload of statements from the Vkontakte network was obtained during a research work organized by the educational company “Academy of DATA-DIVING” (Tomsk), the Institute of Social Sciences of the RANEPA (Moscow), the University Consortium of Big Data Researchers, Tomsk State University (TSU). Data on the manifestation of ageism in real life were obtained using psychodiagnostic tools. The article describes in detail the course of the conducted research, which involved 100 respondents in real life and 100 statements of people represented on the social network. The researchers developed a program for encoding emotional attitudes towards the elderly, which later made it possible to compare and identify statistically significant differences in people's attitudes towards this category of people in the digital environment and in the real world. As a result of comparing the data obtained and identifying the predominance of negative emotions and manifestations of ageism in the social network, the authors proposed a general outline of technology that would potentially be able to identify negative triggers and throw in positive ones. It seems possible to the authors to use a “swarm” of bots, one of which could fix negative triggers, while the remaining ones would act as “extras” giving positive comments. According to the authors, this technology could help improve and stabilize the expression of emotions in the digital environment.
Cartografía temática digital de la cuenca baja del río Luján (1990-2020): un enfoque metodológico de análisis espacial
Authors: Cantarelo Clara
Published: December 2024

El artículo presenta una metodología detallada para generar cartografía temática de usos del suelo en la cuenca baja del río Luján para los años 1990 y 2020, utilizando tecnologías avanzadas como imágenes satelitales, teledetección y Sistemas de Información Geográfica (SIG). Esta metodología abarca desde el preprocesamiento de imágenes hasta la aplicación de técnicas de clasificación supervisada para identificar diferentes coberturas del suelo. Se enfatiza el uso de la clasificación supervisada, respaldada por el conocimiento previo del área, el trabajo de campo y el análisis de índices como el NDVI. Mediante los resultados de la matriz de exactitud, se demostró que las cartografías creadas son precisas y representativas del área de estudio, validadas mediante el método Kappa. Además, se realizan análisis detallados de la exactitud de las clasificaciones por categoría, identificando las categorías con mayor correlación con la realidad.
Entre mapas y comunidades: experiencia e innovaciones en Cartografías Sociales
Authors: Diez Tetamanti Juan Manuel
Published: December 2024

El artículo aborda el desarrollo y aplicación de la Cartografía Social gaúcha o “de los encuentros” desde 2007, destacando su evolución y los aportes metodológicos en la construcción de mapas comunitarios. Esta forma de cartografía surge a partir de la colaboración interdisciplinaria entre geógrafos, trabajadores sociales, sociólogos, arquitectos y antropólogos, consolidándose como una herramienta fundamental en la planificación urbana, rural, la gestión ambiental y la implementación de políticas públicas. Se detalla cómo esta metodología se ha aplicado en diversas experiencias académicas y prácticas, favoreciendo la creación de "planos comunes” que integran las experiencias colectivas de las comunidades, superando la observación externa y buscando una implicación activa en la construcción territorial. Se enfatiza también en cómo el desarrollo de este tipo de cartografía social no pretende generar representaciones, sino que apunta a producir colectivamente. Se subraya la importancia del intercambio de saberes y la participación comunitaria, donde los propios sujetos sociales contribuyen a la creación de los mapas, visibilizando aspectos que las cartografías tradicionales suelen omitir. El artículo incluye una revisión de talleres realizados en diferentes contextos, desde áreas rurales hasta urbanas, donde se abordaron temáticas como el acceso a la salud, la memoria territorial, el ocio juvenil y diversas problemáticas sociales. Además de las aplicaciones prácticas, se resalta la importancia de los aportes teóricos y metodológicos que han enriquecido esta práctica a lo largo de los años. El intercambio con investigadores de América Latina, especialmente de Brasil, ha sido fundamental en la consolidación de la cartografía social, permitiendo la incorporación de nuevas herramientas como el derrotero, que facilita la traducción de objetivos cartografiables en capas visuales y conversacionales. El texto concluye señalando los desafíos futuros de la cartografía social, especialmente en su articulación con las tecnologías emergentes, como los sistemas de información geográfica y la inteligencia artificial. Sin embargo, se mantiene el énfasis en que la base de esta metodología sigue siendo la participación activa de las comunidades, asegurando que los mapas no solo reflejen realidades territoriales, sino que también las transformen y produzcan.
Guarda compartilhada: um importante instrumento de garantia do princípio melhor interesse da criança e do adolescente
Authors: Moura Briana Cassiane dos Santos , Ningeliski Adriane de Oliveira
Published: December 2024

A guarda compartilhada permite que ambos os genitores convivam de maneira equilibrada com seus filhos, dividindo direitos e responsabilidades, mesmo após a separação. A temática tem grande relevância haja vista a necessidade de manejo adequado do fim da conjugalidade, com o escopo de mitigar os prejuízos à parentalidade. Sendo assim, o objetivo geral é verificar se a guarda compartilhada garante o melhor interesse da criança e do adolescente. Busca-se, assim, descrever o princípio do melhor interesse da criança e do adolescente no contexto da guarda compartilhada, com base na legislação brasileira e na doutrina especializada, analisando os diferentes modelos de guarda e suas implicações para o desenvolvimento da criança e do adolescente, sem deixar de identificar os desafios e perspectivas da guarda compartilhada no Brasil e considerar as diferentes realidades socioeconômicas e culturais, visando o atendimento do melhor interesse da criança e do adolescente. Para o desenvolvimento deste estudo, utiliza-se o método dedutivo, que parte de premissas gerais e universais para chegar a conclusões específicas sobre um caso concreto, no caso da presente pesquisa parte-se do pressuposto que a guarda compartilhada seria uma ferramenta capaz de garantir a aplicação do princípio do melhor interesse da criança e do adolescente.  Conclui-se, portanto, que os laços parentais devem ser mantidos de forma mais intacta possível, o que leva ao entendimento que a guarda compartilha garante o melhor interesse da criança e adolescente, quando há ruptura da união conjugal dos pais.
Insolvência transnacional: relevância, insurgência e procedimentos
Authors: Amadei Cauana Stefanie , Serafini Lucas
Published: December 2024

O presente artigo tem como objetivo geral analisar o instituto da insolvência transnacional, instrumento utilizado principalmente pelas empresas e Credores, cujo objetivo é restaurar a vitalidade financeira de uma empresa com atuação em dois ou mais países. Entre seus objetivos específicos estão o de analisar os impactos da lei UNCITRAL, que trata de insolvência no âmbito mundial, e foi trazida ao ordenamento brasileiro, além de verificar a importância do princípio da cooperação internacional nos processos de insolvência, observar quais conflitos de jurisdição podem surgir durante o trâmite da ação, e entender quais os procedimentos e o que se analisa para gerar eficácia no Brasil das sentenças expedidas fora do país, nesses processos. O método utilizado foi o de abordagem dedutivo. Os resultados demonstram que a lei de falências e recuperações brasileira adicionou um capítulo inteiro amparado na regulamentação da UNCITRAL sobre insolvência, sendo trazida com pequenas alterações, para que se adequasse ao ordenamento brasileiro. No tocante ao princípio da cooperação no âmbito internacional, visualiza-se que é fundamental no desenrolar da ação de insolvência, tornando-se indispensável quando há atos a serem prestados em país estrangeiro, estranho à ação principal. Quanto aos conflitos evidenciou-se que existem formas de evitá-los bem como sistemas de decisão, e quanto à homologação do processo estrangeiro de insolvência no Brasil, foi possível validar seu procedimento, a importância do STJ e que o magistrado sempre irá verificar a existência de requisitos para homologação.
Violência contra a mulher no ambiente doméstico e a importância do acolhimento à vítima
Authors: Neves Eduarda Chableski das , Toporoski Elizeu Luiz
Published: December 2024

A violência doméstica é uma problemática social complexa e significativa que afeta milhões de pessoas globalmente, especialmente mulheres. Este tipo de violência inclui comportamentos abusivos físicos, psicológicos, sexuais, econômicos e emocionais, ocorrendo predominantemente em relações íntimas e familiares. Segundo a Organização Mundial da Saúde (OMS), é qualquer comportamento em um relacionamento íntimo que cause danos físicos, psicológicos ou sexuais à vítima. A violência doméstica não discrimina e pode afetar pessoas de todas as idades, raças, classes sociais e gêneros, sendo mulheres e crianças as vítimas mais frequentes. Os impactos incluem danos físicos imediatos, como lesões, e consequências psicológicas duradouras, como depressão e transtorno de estresse pós-traumático (TEPT), além de problemas econômicos e sociais, resultando em isolamento social, perda de emprego e dependência financeira. O objetivo geral desta pesquisa é explorar as diversas formas de violência doméstica, suas causas e impactos, e enfatizar a importância do acolhimento das vítimas como uma estratégia crucial para sua recuperação e empoderamento. Constatou-se que a violência doméstica é uma grave violação dos direitos humanos é uma questão de saúde pública que demanda atenção urgente e multifacetada. Este estudo destaca a complexidade da violência doméstica, suas diversas formas e os profundos impactos nas vítimas, enfatizando a importância do acolhimento integrado como estratégia vital para sua recuperação e empoderamento. As Salas Lilás representam um avanço significativo no atendimento humanizado, oferecendo um ambiente seguro para as vítimas. A criação dessas salas reflete o compromisso do poder público com a igualdade de gênero e a proteção dos direitos das mulheres. Para combater a violência doméstica, é crucial investir em políticas públicas robustas, capacitação contínua dos profissionais, campanhas de conscientização e melhorar a divulgação e acessibilidade dos serviços de acolhimento. A criação de uma rede de apoio robusta pode ajudar a quebrar o ciclo de violência e oferecer às vítimas a oportunidade de reconstruir suas vidas com dignidade e segurança.
Effects of meta-topolin riboside and meta-methoxy topolin riboside on the in vitro micropropagation of Pyrus communis L.
Authors: Dimitrova Natalia G. , Nacheva Lilyana R. , Aleksandrova Diyana V. , Nesheva Marieta K. , Berova Małgorzata Y.
Published: December 2024

The present study aimed to evaluate the effects of new meta-topolin derivatives meta-topolin riboside (mTR) and meta-methoxy topolin riboside (memTR) on the ultiplication and subsequent rooting and ex vitro acclimatization of Pyrus communis L. (‘OHF 333’). The cytokinins mTR and memTR were included in the nutrient medium (0 μM, 3 μM, 6 μM, 9 μM, 12 μM). In plants from three passages of three-week-old cultures grown on different nutrient media, the following parameters were evaluated: multiplication coefficient, fresh (FW) and dry (DW) weight (mg), average length of shoots (mm), average number of leaves, leaf length and width (mm). At the rooting stage, data on the rooting frequency, number of roots per rooted micro-cutting and the length of roots were recorded 18 days after the start of the experiment. In the acclimatized plants, leaf area, FW and DW, and the content of photosynthetic pigments were determined 40 days after the transfer to ex vitro conditions. Gas exchange rate and chlorophyll fluorescence were also evaluated for the control and the variants with 6 and 9 μM mTR and memTR. The plantlets grown on cytokinin-supplemented media showed a higher number of leaves than the control. Plantlets grown on nutrient media with 6 and 12 μM mTR were distinguished by the highest FW and DW. In these variants, the shoots were of the greatest length. The plants grown on medium with 6 μM mTR had the highest number of leaves. Control plants had larger leaves. Тhe highest rooting percentage (70%) was achieved in plantlets grown with 9 μM mTR. A higher ex vitro acclimatization survival rate (76–100%) was found in all plants cultured with mTR or memTR compared to control plants (65%).
Two new Anchigamasus mite species and an unknown male in Anchigamasus halaskovellus (Athias-Henriot, 1967) (Parasitiformes: Parasitidae)
Authors: Witaliński Wojciech
Published: December 2024

Two new parasitid species, Anchigamasus apuseniensis n. sp. and Anchigamasus gardaensis n. sp. collected in Romania and Italy, respectively, are described. Additionally, in Anchigamasus halaskovellus (Athias-Henriot, 1967), a description of an unknown male is provided.
COMPARISON OF SURGICAL TECHNIQUES IN BARLOW’S DISEASE
Authors: Aloi V. , Barbero C. , Stura E. Cura , Avellaneda G. A. Sobrino , Capozza C. , Pocar M. , Salizzoni S. , Rinaldi M.
Published: December 2024

Backgroud and aim:

Barlow’s syndrome is the most advanced and complex in the spectrum of degenerative mitral valve disease; several strategies have been described to face it according to the amount and symmetry of the scallops involved. The aim of this report is to assess repair success and durability, early and late survival, and peri-operative outcomes of patients undergoing surgery for severe mitral valve (MV) regurgitation in Barlow’s disease.

Methods:

Patients with diagnosis of Barlow’s disease undergoing minimally invasive MV surgery from 2010 to 2024 were retrospectively analyzed and divided according to the received operation: ring only, ring+ posterior leaflet (PL) surgery, or ring + anterior or bileaflet.

Results:

199 patients underwent minimally invasive MV surgery: 34 patients received isolated anuloplasty, 99 ring+PL surgery, and 66 ring+anterior/bileaflets surgery. No peri-operative mortality was reported, while stroke occurred in 1 case. Systolic anterior motion occurred in 7 patients and was addressed intra- operatively. Pre-discharge transthoracic echocardiography showed absence of systolic anterior motion, and no or trace of mitral regurgitation.

Recurrence of moderate to severe MV regurgitation or redo was 5.9% in the ring only group, 1% in the ring+PL group, and 3% in the ring+anterior/bileaflet group (p=0.03).

Conclusion:

Minimally-invasive Barlow’s repair is safe and effective at long-term follow- up. No differences in terms of mortality and major complications have been observed among groups. The ring group only presents A higher rate of recurrence of mitral regurgitation was reported in the ring-only group.
RE-INTERVENTION AFTER FAILED MITRAL VALVE REPAIR WITH RING: TRANS-VENTRICULAR BEATING HEART NEOCHORD IMPLANTATION VS STANDARD SURGERY
Authors: Agostini G. , Capozza C. , Ferrante L. , Vairo A. , Barbero C. , Rinaldi M. , Salizzoni S.
Published: December 2024

Background and Aim:

Recurrence of mitral regurgitation (MR) due to leaflet prolapse after mitral valve repair (MVr) may lead to re-intervention, with high risk of morbidity and mortality and challenging re- repair.

The aim is to compare the results of patients with failed MVr with annuloplasty that underwent NeoChord or standard surgery.

Methods:

Between 2006 and 2024, 36 patients were retrospectively enrolled: 14 underwent NeoChord, group A; 22 where reoperated through right mini-thoracotomy (13) or sternotomy (9), group B. There was no statistically significant difference in terms of age (67±4.9 vs 64±9.9), gender (female 28.6% vs 18.2%), EF (58.4±10,6% vs 58.4±8.2%), and EuroSCORE II (3.4±1.1 vs 3.1±1.8).

Results:

All patients in group A underwent successful MVr with a median of three implanted chords while in group B 11 (50%) patients need a MV replacement (p=0.007). Six patients (43%) in group A did not need ICU stay (p=0.003). Transfusions were higher in Group B (7.1% vs 22.7%, p=0.007). Days of hospitalization were significantly lower in group A (4±1 vs 7.8±2.7). Long term follow-up is ongoing.

Conclusions:

In patients with recurrence of MR due to leaflet prolapse in previous standard MVr with annuloplasty, NeoChord shows promising results and may become the standard of care in this selected population.
RISK STRATIFICATION IN RE-OPERATIVE MITRAL VALVE SURGERY
Authors: Capozza C. , Barbero C. , Pocar M. , Aloi V. , Cura stura E. , Filippini C. , Salizzoni S. , Rinaldi M.
Published: December 2024

Background and Aim:

Reoperative mitral valve (MV) surgery is one of the most challenging and high-risk procedure in cardiac surgery. Aims of this study is to analyse our experience on these patients.

Material & Methods:

Retrospective single center analysis on patients undergoing reoperative MV surgery after prior repair/replacement through mid-sternotomy. Primary endpoint was 30-day mortality; secondary endpoints were stroke, re-exploration for bleeding, ICU and in-hospital length-of-stay, and independent risk factors for peri-operative mortality.

Results:

392 patients were enrolled. Logistic EuroSCORE was 19.1±17.3%, and 263 patients (67.1%) had more than one previous cardiac surgery procedure. Former combined procedures were aortic valve surgery in 26 patients (6.6%), TV surgery in 19 patients (4.8%) and coronary artery by-pass graft (CABG) surgery in 17 patients (4.3%). A right mini- thoracotomy approach was performed in 263 patients (67.1%). Stroke rate was 4.3%, re- exploration for bleeding was 6.9%, median ICU and hospital length-of-stay were 2 and 8 days. 30-day mortality was 7.2%.

Creatinine (OR 1.335, 95% CI 1.070-1.665), ejection fraction (OR 0.948, 95% CI 0.921-0.976), previous aortic valve surgery (OR 5.957, 95% CI 2.109-16.820), and diabetes (OR 5.945, 95% CI 2.651-13.392) were identified as independent risk factors for peri-operative mortality

Conclusion:

MV surgery after prior MV operations still represents a demanding procedure with high peri-operative risk. Nevertheless, surgery is still the gold standard for these patients. We believe that the joint of different setting tailored on the single patient after a proper pre-operative screening is the winning strategy to keep perioperative outcome as low as possible
SURVIVAL AND RECURRENCE OF ENDOCARDITIS FOLLOWING MECHANICAL VS. BIOLOGICAL MITRAL VALVE REPLACEMENT FOR ENDOCARDITIS IN PATIENTS AGED 40 TO 70 YEARS: DATA FROM THE INFECT-REGISTRY
Authors: Salsano A. , Di Mauro M. , Labate L. , Della Corte A. , De Bonis M. , Rinaldi M. , Actis Dato G. , Nicolini F. , De Vincentiis C. , Cappabianca G. , Cugola D. , Pacini D. , Vendramin I. , Pilozzi Casado A. , Mikus E. , Onorati F. , Scrofani R. , Musumeci F. , Colli A. , Nicolardi S. , Vizzardi E. , Pantaleo A. , Villa E. , Pollari F. , Barili F. , Parolari A. , Lorusso R. , Santini F. ,   GIROC Study
Published: December 2024

Background and Aim:

Infective endocarditis (IE) is a serious disease, and in many cases, surgery is necessary. The aim of the present study is to quantify differences in long-term survival and recurrence of endocarditis after mitral valve replacement (MVR) for IE according to prosthesis type among patients aged 40 to 70 years.

Methods:

This was an analysis of the INFECT- REGISTRY. Trends in proportion to the use of mechanical prostheses versus biological ones over time were tested. Confounders were adjusted using a doubly robust method that combines regression model with inverse probability treatment weighting (IPTW) by propensity score. Survival was analyzed with Cox models, differences in recurrence of endocarditis were evaluated using the Gray test.

Results:

5253 patients were operated on for IE from 2000 to 2021. Of these,741 aged between 40 and 70 years, underwent MVR. A total of 403(54.4%) received mechanical prostheses, and 338(45.6%) received bioprostheses. A significant trend in the reduction of implantation of mechanical vs. biological prostheses was observed during the study period in patients aged 40 to 50 and 60 to 70 years. Patients with mechanical valves and bioprostheses had comparable early mortality. The improved overall survival rate in the patients who received a mechanical prosthesis than those receiving a biological prosthesis showed a trend toward significance at Cox analysis adjusted for propensity score weighting (HR 0.746, 95% CI:0.53–1.03, p=0.07). Mechanical prostheses were associated with significantly less recurrent endocarditis after AVR than biological prostheses (Gray’s test p<0.001).

Conclusions:

The present analysis of the INFECT-REGISTRY shows increased survival and reduced recurrence of endocarditis after a mechanical MV implantation in middle- aged patients.
MINIMALLY INVASIVE MITRAL VALVE SURGERY IN ELDERLY
Authors: Mikus E. , Fiorentino M. , Sangiorgi D. , Calvi S. , Tenti E. , Tripodi A. , Costantino A. , Savini C.
Published: December 2024

Background:

Right anterior minithoracotomy has become the preferred approach for mitral valve surgery. This study assesses outcomes in elderly patients to determine potential benefits.

Materials and Methods:

From January 2010 to May 2024, 4092 adult patients underwent mitral valve repair or replacement, with 1687 using a minimally invasive approach. We focused on elderly patients aged ≥75 years (n=383) treated with a minimally invasive approach and a subgroup aged ≥80 years (n=144).

Results:

In patients aged ≥75 years, 48.3% were male. Among 383 patients, 1.8%(n=7) had endocarditis, 6.3%(n=24) had undergone previous cardiac surgery. The median logistic EuroSCORE was 7.48(IQR 4.92). Median cardiopulmonary bypass time was 95 (IQR 56) minutes and aortic cross-clamp time was 76 (IQR 46) minutes. Median ventilation time was 7(IQR 7) hours, and median ICU stay was 2 days. Main postoperative complications were atrial fibrillation (20.1%) and acute renal failure (3.1%). The hospital mortality rate was 3.1% (n=11). In the ≥80 years subgroup, the Logistic EuroSCORE increased to 8.97, with a mortality rate of 5.3%. Atrial fibrillation (22%) and acute renal failure (3.5%) were the most common complications. Logistic regression identified acute renal failure as a key risk factor for mortality (p<0.001) in both the main groups

Preoperative risk factor analysis using logistic regression identified the logistic EuroSCORE as the only significant risk factor (p=0.013), with mortality notably increasing when the logistic EuroSCORE was ≥11.59

Conclusions:

Right anterior minithoracotomy is a safe and reproducible approach, even for elderly patients, promoting faster recovery with lower risks of complications.
FEATURES AND RISK STRATIFICATION IN ENDOSCOPIC MITRAL VALVE SURGERY. DOES GENDER BIAS EXIST?
Authors: Brega C. , Sangiorgi D. , Savini C.
Published: December 2024

Background and Aim:

Since 10 years, gender bias is source of interest in cardiac surgery: women patients are supposed to have longer cardiological history, later referral to surgery and higher postoperative complications rate. The last frontier of minimally invasive cardiac surgery is the endoscopic approach, that makes surgery more customized.

Methods:

During the last 2 years 143 patients underwent endoscopic mitral valve surgery: 54 women and 89 men. Surgical access is through the 4th intercostal right space, positioning the camera on the anterior/mid axillary line. Baseline characteristics were similar between the 2 groups; median age in males was 61, in females 64 (p= 0.008). Median EuroSCORE log and II were higher in the female group: 1.86 and 0.67 versus 4.11 and 1.28 (p < 0.001).

Results:

Mitral valve repair was performed in 134 patients (94% vs mitral valve replacement in 6%). Similar CBP and cross-clamping time were reported (F: 169 and 114 minutes; M: 183 and 121 minutes). 30-day and in-hospital mortality were 0.6 and 2% respectively. No statistically significant difference was reported between the groups in terms of mortality, reoperations for bleeding (p= 0.55), transfusion rate (p= 0.069), respiratory (p=0.78) complications, pacemaker (PM) rate implantation (p=0.378), sepsis (p=0.55), and acute kidney injury (p=1). Postoperative EF were similar, with higher transmitral gradients in women (3.9 vs 2.9 mmHg).

Conclusion:

Our standardised approach for endoscopic mitral valve surgery is safe, makes the surgical gesture precise and reproducible and levels out the potential differences due to gender bias.
RE-REPAIR AFTER PREVIOUS MITRAL VALVE SURGERY
Authors: Sobrino Avellaneda G. A. , Barbero C. , Aloi V. , Capozza C. , Di Lorenzo D. , Salizzoni S. , Pocar M. , Rinaldi M.
Published: December 2024

Background and Aim:

Evidences in the literature show that close to 20%of patients undergoing primary mitral valve (MV) surgery require reoperation on long-term follow-up, and significant proportion of this patients received a conservative operation. Aim of this study is to analyze outcome of patients undergoing a second MV repair operation.

Methods:

Patients who underwent redo MV repair between 2012 and 2024 were retrospectively analysed. Primary outcomes were mortality and freedom from MV reoperation at 30 days.

Results:

Twenty-seven patients were included. Mean age was 63 years and 20 (74%) were men. Progressive mitral valve degeneration was the most common cause of previous repair failure (88%). Median time to reoperation was 4,5 years. Re-repair was most commonly performed through a minimally invasive approach (81%) with the endo-aortic clamp (63%). MV annuloplasty was performed in the 70% of the cases, and artificial chords were implanted in the 59% of the cases. Re-exploration for bleeding, stroke, and acute renal dysfunction were reported in 1, 2, and 2 cases respectively. Thirty-day mortality was reported in 1 case, while 3 patients required a reoperations in the follow-up period.

Conclusions:

The emergence of MV repair as the preferred treatment for severe mitral regurgitation caused by degenerative disease has been accompanied by an increasing number of valve repair failures seen by surgeons. This report shows that MV re-repair is feasible and effective in high volume, high experienced centers in MV surgery.
MINIMALLY INVASIVE ISOLATED TRICUSPID VALVE SURGERY: LATE OUTCOME FROM A MULTICENTER STUDY
Authors: Russo M. , Mach M. , Pollari F. , Lio A. , Di Mauro M. , Taramasso M. , Berretta P. , Della Corte A. , Scrofani R. , Greco E. , Saitto G. , Sponga S. , Leviner D. , Vinciguerra M. , Troise G. , Bianchi G. , De Vincentiss C. , Ranocchi F. , Andreas M.
Published: December 2024

Background and Aim:

To compare the long-term mortality and postoperative adverse events of minimally- invasive isolated tricuspid valve surgery (ITVS) to median sternotomy in an all comers registry.

Methods:

This retrospective observational study was conducted in the international multicenter SUR-TRI registry, which included patients who underwent isolated TV surgery in 15 different European centers.

Results:

This study included 476 patients (median age 58.1 years; 44.7% male) who underwent isolated TV surgery either using the minimally invasive approach (MICS; n=72) or median sternotomy (STERNO; n=404). While the reported cardiopulmonary bypass time was significantly longer in MICS (112 vs. 80 minutes; p<0.001), MICS patients less frequently required postoperative blood transfusions (31% vs. 51%; p=0.002), required significantly shorter intensive care (2 vs. 3 days; p<0.001) and had a shorter in-hospital stay (10 vs. 13 days; p=0.054). After surgery, patients were followed for a median of 46.4 (IQR: 9.3-91.4) months, during which 112 patients died (50 cardiac, 62 non-cardiac). Even after adjusting for baseline comorbidities (i.e. EuroSCORE II) and repair/replacement, the minimally invasive approach significantly reduced the risk of all-cause mortality (adjusted HR: 0.430 [95%CI: 0.228-0.819]; p=0.009). This benefit was primarily the result of a reduction in noncardiac mortality (adjusted HR: 0.194; p=0.006).

Conclusion:

Minimally invasive isolated tricuspid valve surgery may not only improve long- term survival, but also reduce postoperative complications and intensive care stay when compared to median sternotomy in suitable patients. Early timing associated with MICS, beating heart and repair strategy may significantly improve outcome of an upcoming procedure historically considered prohibitive.
PATIENT SELECTION AND OUTCOMES OF TRANSCATHETER TRICUSPID VALVE INTERVENTIONS WITH A DEDICATED HEART TEAM
Authors: Russo M. , Cammardella A. G. , Pergolini A. , Ciaramella P. , Candido F. , Cacioli G. , Menafra G. , Lio A. , Nicolo F. , Sbaraglia F. , Ranocchi F.
Published: December 2024

Background and Aim:

Transcatheter procedures for the treatment of tricuspid valve regurgitation have been introduced as a valuable tool for the treatment of high-risk patients.

Methods:

Sixteen patients (2021-2024; median age 82 y.o, 70% female) with significant tricuspid regurgitation underwent transcatheter treatment. A dedicated structural valve team has been established for patient selection, treatment and strict follow-up.

Results:

All cases enrolled were considered at high-prohibitive surgical risk (Median TRI- SCORE 28%, range 8-64%). A strict evaluation of RV function was carried out with echocardiography and right heart catheterization. Device selection has been carried out according anatomic criteria, coaptation gap and main jet location. Nine patients presented a coaptation gap < 8.5 mm and were treated with edge-to-edge repair, three case exhibited severe annular dilation and were treated with annuloplasty and four remaining cases (not suitable for leaflets or annular techniques) were treated with etherotopic valve implantation. Procedural success was achieved in 93% of cases. Three patients died at 30 days, one for acute right heart failure, one for respiratory failure and a third for pneumonia. A significant improvement of functional status was reported at follow up intervals of 3-6 and 12 months (NYHA class 3±0.5 vs 1.5±0.5). Among patients who completed 1-year follow-up (75%) no late death or rehospitalization for heart failure were detected.

Conclusions:

Transcatheter tricuspid valve interventions represent a needed tool in the hands of the modern cardiac surgeon. Patient’s selection and surgical risk assessment are crucial to optimize outcome.