bluuebunny/crossref_metadata_2025 huggingface dataset:
Preservation of Balinese batik knowledge as an effort to preserve indigenous knowledge
Authors: Igiriza Miftahunnisa' , Valentino Rahmat Alifin , Wiradharma Gunawan , Fadhli Rahmat , Adamy Zulham , Anjani Afifah
Published: January 2025

Balinese batik, a traditional cloth, is rich in motifs and philosophical meanings that reflect the culture of the Balinese people and need to be preserved. Preservation efforts aim to ensure that the knowledge contained in Balinese batik can be sustainable in the long term. This study examined the knowledge and preservation of Balinese batik cloth to preserve indigenous knowledge. This study used a qualitative method by analyzing the knowledge contained in Balinese batik cloth using Peirce's semiotic approach and a case study to explore the preservation efforts carried out by the UPTD Bali Museum. The data collection technique used interview and observation methods, which were conducted from May to June 2024. Data analysis was carried out through data reduction, data presentation (data display), and conclusion. Study results showed that if examined more deeply, Balinese batik contained philosophical meanings that reflected the culture of Balinese society due to the influence of Hinduism and local values. Balinese batik motifs were also inseparable from the influence of Chinese cultural elements that contain spiritual and mythological values. The Bali Museum conducted preservation efforts through processes such as identifying and validating knowledge in local communities and academic circles, recording and storing this knowledge in a database, and disseminating it to the broader community. This study concludes that Peirce's semiotics can assist in identifying the indigenous knowledge of Balinese batik, and in this case, the Bali Museum plays an important role in preserving local wisdom.
Piano sight-reading teaching and music education: A systematic literature review
Authors: Rui Ruiqing , Amran Muhammad Syawal , Nasri Nurfaradilla Mohamad
Published: January 2025

Piano sight-reading competency, which is highly important for an aspiring musician who needs to face diverse musical problems, is an integral part of becoming a smooth performer. The aims of this systematic literature review concerning piano sight-reading pedagogy approaches between 2019 and 2024 are to determine the strengths and weaknesses of the peer-reviewed literature. The article examines cognitive, behavioral, and technological methods and tools of enhancing learning outcomes, based on the concept of cognitive load, constructivism, and behaviorist perspective. The cognitive strategies highlight the role of hand-eye coordination, short-term memory, and visual process; while the behavioral ones emphasize the importance of daily practice and feedback from the teacher. Emerging technologies, like VR and AI-driven platforms, are redefining education and offering unique ways of learning and forgetting. While achievements of the past are notable, challenges such as access and efficacious long-term approaches remain. The next step of research should be to focus on sustainable teaching methods and international perspectives to achieve homogeneous and effective sight-reading teaching worldwide. This essay provides an overview of integrated and adaptable teaching strategies that combine both traditional and modern tools for the development of versatile and confident musicians’ skills.
Ways to enhance the status of the Arabic language between authenticity and challenges
Authors: Alsaied Mohamad Abdullah
Published: January 2025

For linguists, language is a system of abstract phonetic, phonological, lexical, synthetic, semantic, and pragmatic relations, and a tool for communication and expression. It is knowledge, culture, literature, civilization, and behavior. Therefore, language is considered the pillar of the nation and an important foundation for its civilization that expresses its entity and culture. The Arabic language is one of the basic constants of the Arab and Islamic nation, as it is the symbol of its identity and the tool of its artistic creations, and a landmark of its intellectual and literary production. Thinking about the present and future of the Arabic language is one of the most important interests that attract elites among linguists, thinkers and writers, and is closely related to the sovereignty of the Arab-Islamic nation, its culture and thought. To achieve the goal, the research was divided into three sections. The first dealt with the definition of language, Arabic and its position, the second discussed the most important contemporary challenges, and the third dealt with ways to confront these challenges and enhance the position of Arabic with all means of support and capabilities. These methods include presenting case studies of educational reforms and language policies in Arabic-speaking countries, in addition to referring to modern technical and linguistic initiatives, and comparing with languages that have succeeded in adapting to globalization (such as Chinese). These measures will have a significant impact on enabling Arabic to attain the status it deserves, its authenticity and historical precedence. The practical results of the study target decision-makers, educators and language institutions, allowing them to develop policy and executive frameworks, update curricula, and employ digital tools to protect and modernize the Arabic language in a global context. Through these applicable recommendations, the status of Arabic can be consolidated and ensure that it remains authentic and renewed at the same time.
The ANP method to relate innovative personal competencies in sustainable development in Ecuadorian fruit exporting SMEs
Authors: Luis Asencio Cristobal , Sandra Zapata Vega , Carla Andrade Arteaga , Germán Narváez Vásquez , Narcisa Núñez Gallardo
Published: January 2025

The development of the personal innovative competences in workers is of capital importance for the competitiveness of organizations, where the ability of the employees must respond in an innovative way to diverse situations that arise in specific contexts. Considering this, the question arises: How do innovative employees’ competences affect the sustainable development of Micro, Small and Medium Enterprises (MSMEs)? Therefore, the objective of this work is to present a multi-criteria method based on the Analytic Network Process (ANP), to relate innovative personal competences and the sustainable development of MSMEs. An instrument was applied to groups of experts from 31 Ecuadorian fruit-exporting MSMEs, to develop a multi-criteria decisional network that allowed identifying the innovative personal abilities that have the greatest impact on the sustainable development of these organizations. The results demonstrate the relevance of the elements of innovative personal competencies, with a cumulative participation of 39.15%, Sustainable Export Development with 32.18% and Improvements with 28.66%. It also presents three types of analysis: i) Global to establish the weight of each variable; ii) Influences, to establish solid cause-effect relationships between the variables and iii) Integrated. The most relevant innovative personal competences for sustainable development and improvements for exporting SMEs are teamwork, critical thinking, and creativity within the international context.
Investigation Of The Effects Of STEAM- Based Art Education On The Photography and Photo- Manipulation Works Of Gifted Students
Authors: Özalp Hamarta Hatice Kübra , Kervan Naciye
Published: January 2025

The aim of the research is to reveal the effect of STEAM-based art teaching on photography education given to secondary school students and students' photo-manipulation studies. In line with this purpose, it was aimed to use manipulation in education in a positive way with the manipulation applications that the students made on the photographs they took at the end of the activities made more comprehensive with the STEAM approach. The problem of the research was determined as ‘What is the effect of STEAM-based art teaching on gifted students’ photography and photo-manipulation studies?’. In this context, the research was planned as a qualitative study and was designed as a quasi-experimental study. The data obtained in the research were analysed by content analysis method. During the implementation process of the research, it is noteworthy that the students actively participated in the lesson, successfully completed the activities and performed above the expectations of the researcher. In the findings related to the research questions, students' motivations towards the course, their interests and perspectives towards photography, their thoughts on the process of creating photo-manipulation, and their opinions on the course process and participants were reached. As a result of the research, it was seen that the students' awareness of photography and photo-manipulation increased, they started to put the education they received into practice and started to use it in real life, each student mentioned at least one photo editing programme, and all of the students stated that they used the photoshop programme. Considering the results of expert opinion, it was concluded that the students showed a positive development from the 1st activity to the 3rd activity in photography and photo-manipulation studies. Considering the results obtained from the student interview form findings, it was observed that there were students who stated that the students improved themselves, contributed to their general culture and gained a different perspective. In this direction, it was concluded that the education they received fulfilled its objectives.
Towards a buoyant political ecology: Rethinking marginalization for coastal climate change adaptation in the tropics
Authors: Rangan Haripriya , Carney Judith
Published: January 2025

The land-water dichotomy plays a key role in the prevailing global climate change adaptation (CCA) policy discourse for tropical coastal areas. This dichotomy is implicitly informed by a land centered conception of property which regards areas that fluctuate between water and land, or 'aquaterras', as marginal and in need of development to make them economically profitable. By adopting this perspective, mainstream CCA policies ignore the diverse, vernacular systems of adaptation that communities that dwell in such tropical coastal aquaterras have developed through multigenerational and lived experiences to negotiate climatic and contingent uncertainties. The article calls on political ecologists to jettison land-centered, economic representations of marginality and marginalization in favor of a 'buoyant', critical CCA approach which recognizes and builds on the vernacular knowings and expertise of tropical coastal aquaterra communities.
Board Independence, Audit Committee Characteristics, and Sharia Supervisory Board on Audit Report Lag
Authors: Julfa Siti , Wafiroh Novi Lailiyul
Published: January 2025

This study aims to empirically examine the effect of board independence, audit committee size, audit committee expertise, audit committee meetings and sharia supervisory board on audit report lag. The object of research includes Islamic banking, including Islamic Commercial Banks (BUS) and Sharia Business Units (UUS) listed on the Financial Services Authority (OJK) during the period 2019-2023. The sample determination was carried out through a purposive sampling technique, resulting in 130 samples that met the research criteria. Data analysis was performed using logistic regression. The research findings reveal that board independence, audit committee size, and the existence of a sharia supervisory board have a significant negative effect on audit report lag. In contrast, audit committee size and audit committee expertise do not have a significant effect. The novelty of this research lies in the use of DPS variables and the type of measurement due to the Indonesia Stock Exchange (IDX) policy that extends the deadline for submitting financial reports. This research provides an understanding of the factors that have the potential to accelerate audit completion and reduce audit report lag.
Analisis Pengaruh Kepemilikan Asing, Kinerja Lingkungan Dan Ukuran Perusahaan Terhadap Pengungkapan Corporate Social Responsibility
Authors: Hanifah Apriliyah Nur , Umaimah Umaimah
Published: January 2025

Many companies ignore their social responsibility, but companies forget that social responsibility is an important attribute to improve a company's good reputation. Currently companies are developing capital and improving the environment, companies are paying more attention to the surrounding environment because the environment around the company can influence the company. This research was conducted with the aim of measuring the influence of foreign ownership, environmental performance and company size on Corporate Social Responsibility disclosure. This research selects manufacturing companies listed on the Indonesia Stock Exchange (BEI) in the 2023 period. The sample in this research consists of 40 samples taken using the purposive sampling method used in this research is multiple linear regression analysis using SPSS. The research results show that foreign ownership does not have a significant effect on the scope of Corporate Social Responsibility, company size also does not have a significant effect on the scope of Corporate Social Responsibility, but environmental performance has a significant effect on the scope Corporate Social Responsibility.
STRUKTUR POPULASI, KOMPOSISI PROKSIMAT DAN MINERAL KEONG GONDANG (Pila scutata) PADA EKOSISTEM PERSAWAHAN DI WILAYAH KABUPATEN GIANYAR
Authors: Suartini Ni Made , Sudatri Ni Wayan , Amalia Dewi Sabrina , Fitriyah Waifatul
Published: January 2025

The Pila scutata is a species of Mollusca Phylum that is also known as the kakul in Bali and the gondang snail in Indonesia. The environment of rice fields is one of the snail's habitats. Snails are utilized in religious ceremonies in Bali as a ceremonial component and as an alternate source of protein. The purpose of this study was to ascertain the snail population structure, including density, frequency of presence, and dispersion patterns in Gianyar Regency's rice field ecosystem. The snail sample's mineral and proximate compositions were also examined. Samples were collected from three plots of rice fields with rice plants that were less than a month old at each of the several rice field locations. Sampling using a 1m × 1m square positioned in every rice field corner. Environmental factor measurements are made for every sample. Samples of snails collected from every site were brought to the laboratory for morphological analysis and counting. According to research result, there were 0,83–2,0 ind/m2 of snails, 58,33–91,67% of the frequency of present, and their distribution pattern was regular. There was more than 50% protein. Iron 18,987–38,70; potassium 162,886-216,121, 407,082–567,960 mg/100g; copper and lead not found. Calcium content ranges 90,347–122,97 mg/100g.
Keywords: Freshwater snail; native species; nutrition; rice field
DAMPAK SOSIAL, EKONOMI DAN LINGKUNGAN PENGEMBANGAN KAWASAN EKOWISATA PANTAI LABUHAN BANGKALAN MADURA
Authors: Sugiarti Teti , Kryshna Pratama Guntur , Subari Slamet
Published: January 2025

The development of mangrove-based coastal ecotourism is expected to make a significant contribution to local economic development. The purpose of this study is to determine the socio-economic and environmental impacts of the development of Ecotourism Labuhan Bangkalan Beach (EPLB) Madura. This research uses a descriptive method with purposively selected sources. Primary data collection was conducted through interviews with people inside and outside the tourist area. Labuhan Village people who carry out activities inside and outside the area are managers, workers, traders, and the community. The results showed that the development of EPLB tourism objects had a positive and negative impact on socio-economic and environmental changes in the Labuhan Bangkalan Village community. Social aspects of positive impacts include changes in people's lifestyles, community support for developing sustainable tourism objects, community involvement in sustainable tourism development, and the establishment of cooperation between tourism object managers and related parties. The negative impacts are the potential for increased conflict between communities, noise, security and free association. From the economic aspect, there are new job opportunities in the tourist area, new business opportunities such as selling food and drinks inside and outside the tourist area, and increasing community income. Negative impacts that occur are uneven income and increased living costs. From the environmental aspect, there is an increase in local community knowledge about the benefits of mangroves, improvement of infrastructure to tourist areas such as roads and lighting, and handling local waste generated by visitors and surrounding households that are stuck to mangrove roots. Negative impacts include domestic waste disposal and pollution.
Keywords: Labuhan Beach Ecotourism; Mangrove; Socio-economic & Environmental Impacts; Labuhan Village; Mixed Methods
PEMODELAN ANGKA KRIMINALITAS DI PULAU JAWA DENGAN METODE GEOGRAPHICALLY WEIGHTED REGRESSION (GWR)
Authors: SETIAWAN I WAYAN TEDY , SUCIPTAWATI NI LUH PUTU , DWIPAYANA I MADE EKA
Published: January 2025

Transformasi dalam perilaku masyarakat dapat secara substansial memengaruhi dinamika tindak kejahatan. Pulau Jawa merupakan pulau yang memiliki angka kriminalitas tertinggi di Indonesia pada tahun 2022. Hal tersebut membuktikan bahwa angka kriminalitas di wilayah Pulau Jawa tidaklah sedikit, maka dari itu penting untuk mengetahui wilayah-wilayah yang rawan terjadi kriminalitas dan faktor-faktor apa saja yang melatarbelakangi kriminalitas tersebut. Geographically weighted regression (GWR) merupakan suatu teknik statistika yang digunakan untuk mengkaji variasi/heterogenitas spasial atau perbedaan di berbagai wilayah. Tujuan dari penelitian ini adalah membuat model Geographically weighted regression (GWR) angka kriminalitas di Pulau Jawa beserta faktor-faktor yang memengaruhinya. Hasil dari penelitian ini menunjukkan dalam pemodelan didapatkan bahwa model GWR dengan fungsi pembobot kernel adaptive bisquare yang terbaik dengan koefisien determinasi () sebesar 74,22% dan nilai AIC terendah sebesar 1796,1 dan peubah yang signifikan berpengaruh terhadap angka kriminalitas di seluruh kabupaten / kota di Pulau Jawa adalah Upah Minimum Kabupaten (UMK).
Unraveling the Impact of Collaborative Competency on Collaborative Governance in Public Sector Organizations
Authors: Djalil Muslim A. , Chan Syafruddin , Putra Teuku Roli Ilhamsyah , Tabrani Mirza , Agustina Maulidar
Published: January 2025

Objective: The study investigates the influence of collaborative competency on collaborative governance, with innovative governance serving as a mediator, in the provincial government agencies of Aceh Province, Indonesia.
 
Theoretical Framework: the application of innovative governance to mediate the influence of collaborative competency on collaborative governance in the public sector.
 
Method: The research utilizes the Amos software as a data processing instrument to employ the Structural Equation Modeling (SEM) quantitative model. The investigation was conducted with 242 government officials from 54 Provincial Government Working Agencies (SKPA) in the province, representing top, middle, and operational management. Data of respondents were collected by disseminating closed-ended questionnaires in the form of Google forms via email and the provincial agency's WhatsApp group.
 
Results and Discussions: The findings indicate that collaborative competency has significant direct effects on both innovative and collaborative governance, as well as a direct effect of innovative governance on collaborative governance. Additionally, the relationship between collaborative governance and collaborative competency is mediated by innovative governance.
 
Research Implications: This research suggests that the quality and efficiency of public service delivery can be improved by enhancing collaborative competencies within government agencies, which can result in more effective and innovative governance practices. This emphasizes the necessity of creating policies and training programs that encourage the development of innovative approaches and collaborative skills among government officials.
 
Originality/Value: In contrast to prior literature, which has primarily examined human resource competencies, effective governance, collaborative governance, employee productivity, and organizational performance. Nevertheless, the comprehensive investigation of the role of innovative governance in mediating the relationship between collaborative competencies and collaborative governance, particularly in the provincial government context, has not yet been completed.
Reconsidering “Blue Boy Trial”: Sex Reassignment Surgery in Postwar Japan and the “Gatekeeper Model”
Authors:   The Korean Association For Japanese History, Kim Seong-Un
Published: January 2025

The 1965∼69 “Blue Boy Trial,” in which a doctor was found guilty of breaching Article 28 of the Eugenic Protection Law after he was indicted on charge of having performed sex reassignment surgery (SRS) on three “blue boys”(trans woman entertainer or prostitute), has been known to have brought a “dark age” to SRS in Japan. However, the court did state that SRS could be considered a legitimate treatment if operated with careful procedures. This court decision was made based on the documents obtained by the defendant from the United States. These documents reflected the movement toward the expansion of transgender healthcare of US in the 1960s. This movement was led by endocrinologist Harry Benjamin and large hospitals such as Johns Hopkins Hospital that sought to systematically approach SRS. The gender identity clinics in those large medical institutions adopted a so-called “gatekeeper model,” a step-by-step procedure in which they carefully chose candidates and treated them based on the narrow definition of “transsexual.” This model was also employed by university-based medical institutions in Japan by 1990s when these hospitals launched SRS. Therefore we need to reconsider “Blue Boy Trial” in the context of bringing to Japan the “gatekeeper model” of SRS that had been originated from the United States in the 1960s. However, this “gatekeeper model” with particular emphasis on the step-by-step approach and the “real-life test” significantly limited transgenders’ access to the surgical procedure, and compelled them to find other clinics that were independent of “gatekeepers.”
From Ideas to Politics: the Imperial Loyalism in the Mito-Court Relations
Authors:   The Korean Association For Japanese History, Kim Hyungjin
Published: January 2025

When explaining the process of establishing the modern state of Japan, the rise of imperial loyalism and the impact of external pressure have been emphasized. However, although these are the necessary conditions for the emperor’s political emergence, they are not sufficient conditions in themselves.
In order to explain the emperor’s emergence in the Bakumatsu Era, it is necessary to pay attention to the process of ’politicization of ideas’, that is, the process in which ideas that value the existence of the emperor and seek to further enhance the emperor's authority are connected to political movements in reality.
This study attempted to analyze the movements surrounding the imperial court that existed in reality, rather than the discourses of scholars and thinkers who had no special contact with the court. Focusing on the ideas and movements of those who were directly or indirectly related to the administration of the court, this article reveals in more detail the journey of the ideas surrounding the emperor to the political arena in reality.
In this article, it was revealed that the revival of the emperor’s ancient-style posthumous name in 1841 marks a milestone in the relationship between Takatsukasa Masamichi and Tokugawa Nariaki, each of whom were the top figures in the court noble class and the warrior class at the time.
Development and Validation Study of a STEAM Children’s Future Competency Measurement
Authors:   Gyeongin National University of Education, Lee Yunsoo , Eom Hoijeong , Lim Heejun , Lee Jeongrim , Hong Meeyoung , Kim Jiwon , Park Hyeyeon , Bae Suwan
Published: January 2025

This study aims to develop and validate a STEAM children’s future competency measurement. A systematic literature review was conducted to collect and analyze STEAM-related literature, and seven factors comprising 50 items were constructed after review by external subject matter experts. We collected survey data twice from children aged 7–9 years old, with 413 responses in sample 1 and 425 responses in sample 2. Factor analysis (i.e., exploratory and confirmatory factor analyses), reliability test, and Rasch model analysis were performed. Eventually, seven factors comprising 43 items were validated. Based on the findings, we discussed the academic and practical implications, as well as suggestions for future research.
Autoethnographic Study of Experiences Working at an International Baccalaureate World School and International Baccalaureate Candidate Schools in Two Regions: Focusing on Three Dimensions of Conflict
Authors:   Gyeongin National University of Education, Baek Sun-Young
Published: January 2025

This study aims to provide an understanding of how the introduction of the International Baccalaureate (IB) Primary Years Programme affects the operation of the curriculum and teachers’ lives through the experience of one teacher. The researcher worked as an elementary school teacher at an IB world school and IB candidate schools in different regions. The autoethnographic research method was applied to reveal the researcher’s unique experience and explore its meaning, and conflicts were described with a focus on three aspects: relational, structural, and internal conflicts. First, the researcher experienced relational conflict, wherein teachers competed with or were alienated from each other depending on their expected roles in the IB school. Second, the researcher experienced structural conflict that arose from the formation of different commun ities between schools depending on the IB accreditation stage. Third, the researcher experienced internal conflict because of the burden of having to inform and persuade about the effectiveness of the IB along with the desire to be recognized as an IB education expert. On the other hand, the researcher experienced that the special characteristics of elementary schools can be expressed by restructuring the curriculum centered on transdisciplinary topics, which increased the actual cooperation of teachers and improved the quality of education. Therefore, indicators for teachers to develop their professionalism and a practical system for managing the quality of school education should be established.
Plan pistola: ¿crimen de guerra?
Authors: Bossa-López Gineth Juliana
Published: January 2025

Este artículo de investigación examina el plan pistola como estrategia de las FARC-EP; aclara los roles de la fuerza pública en Colombia y presenta cifras respecto de los homicidios selectivos de los cuales han sido víctima. Posteriormente, analiza el rol del combatiente como persona protegida a la luz del DIH “Hors de Combat” y, por ende, sujeto de protección; explica por qué el plan pistola es un crimen de guerra. Finalmente, bajo el instrumento nacional de víctimas, analiza las razones por las cuales el plan pistola es un hecho victimizante para la fuerza pública. En este punto se delimita el concepto de víctima para miembros de la fuerza pública.
Legal support for the sustainable development of indigenous minorities of the North, Siberia and the Far East: results and prospects
Authors: Semenova Irina  Vladimirovna
Published: January 2025

The article examines the features of the legal regulation of the sustainable development of the indigenous peoples of the North, Siberia and the Far East. Special attention is paid to the Concept of Sustainable development of the indigenous peoples of the North, Siberia and the Far East in the context of updating this document in the near future. The Russian Federation is a multinational state, for which taking into account the traditions, culture and historically established way of life of each people living on its territory is one of the main directions of state policy. The indigenous peoples of the North are a social group that requires additional state support, not only because of their small number, but also because of the difficult climatic conditions of the places where these peoples live. The article considers the configuration of legal regulation in the field of sustainable development of indigenous peoples both in historical retrospect and at the present stage. Special attention is also paid to promising areas of development of state regulation, as well as measures of state support in this area. It is noted that at present the legal regulation of the sustainable development of the indigenous peoples of the North, Siberia and the Far East is at the stage of significant changes. The paper identifies the main differences between the current Concept and the Draft of the future one, concerning the fundamental aspects of policy. In particular, the principle of recognizing the right of the peoples of the North to priority access to fishing grounds and hunting grounds, to biological resources in places of their traditional residence and traditional economic activity, as well as modernization, updating of technical equipment, etc. At the same time, the author draws attention to the need to comply with environmental requirements and respect for nature in the process of implementing new tasks.
Predictive value of technetium-99m sodium pertechnetate thyroid scintigraphy in determining the permanence of congenital hypothyroidism
Authors: Li Wai Ip , Chan Tak Kwong , Ng Koon Kiu , Kung Boom Ting
Published: January 2025

Objectives:

We aim to investigate the predictive value of [99mTc] pertechnetate thyroid scintigraphy in determining the permanence of congenital hypothyroidism (CH).

Material and Methods:

A retrospective analysis of [99mTc] pertechnetate thyroid scans performed for evaluation of CH at the Nuclear Medicine Unit of a hospital in Hong Kong between January 1, 2008, and December 31, 2018, was conducted. Scintigraphic findings and parameters at diagnosis, including thyroid stimulating hormone (TSH), free thyroxine (fT4), gender, and gestational age, were reviewed. The need for lifelong thyroxine replacement therapy was reviewed.

Results:

The study included 85 subjects, with 74 (87.1%) presenting with eutopic thyroid and 11 (12.9%) showing thyroid dysgenesis. Patients with scintigraphic evidence of thyroid dysgenesis required permanent thyroid hormone replacement therapy. Among the patients with eutopic thyroid, a higher TSH level was associated with the need for lifelong thyroid hormone replacement therapy (cutoff TSH value 18.72 mIU/L, sensitivity 77.3% and specificity 53.8%). Gender, gestational age, and fT4 did not show significant differences between the transient and permanent CH groups in patients with eutopic thyroid.

Conclusion:

Scintigraphic findings of thyroid dysgenesis indicate a high prevalence of permanent CH. In patients with eutopic thyroid, higher TSH levels predict the requirement for lifelong thyroid hormone replacement therapy. These results provide insights into the prediction of CH and aid in individualized treatment decisions for patients with CH.
THE CLINICAL SIGNIFICANCE OF DETERMINING MARKERS OF APOPTOSIS IN BLOOD SERUM AND URINE OF CHILDREN WITH CHRONIC KIDNEY DISEASE
Authors:   City Children's Clinical Polyclinic No. 10, Minsk, Belarus, Kandratsenka O. A. , Kazyra I. A. ,   Belarusian State Medical University, Minsk, Belarus
Published: January 2025

Background. The results of the analysis of the content of apoptosis markers in the blood serum and urine of pediatric patients with chronic kidney diseases are presented. The prospects of using granzyme B and annexin V in the complex diagnosis of chronic nephropathies and assessment of their progression are discussed. Objective. To analyze the prospects of determining granzyme B and annexin V levels in blood serum and urine of pediatric patients for the complex diagnosis of chronic kidney diseases. Material and methods. We examined 100 children with chronic glomerulopathies. The comparison group included patients with chronic non-glomerular nephropathies. Quantitative determination of the level of apoptosis markers was performed by enzyme immunoassay. Results. The concentration of granzyme B in blood serum (N=159, p<0.001) as well as in urine (N=158, p<0.001) significantly differed between all the studied groups. Comparison of the content of annexin V in serum (N=136, p<0.23) and urine (N=138, p<0.20) of patients from all groups showed no statistically significant differences. There were no correlations between the concentration of annexin V in blood serum and urine and the characteristics of renal functions (serum creatinine, serum urea, GFR) and the activity of the pathological process (CRP, ESR, daily proteinuria). Conclusions. Determining of granzyme B levels in blood serum and urine can be used in the diagnosis of chronic kidney diseases in children, including the differential diagnosis of glomerular and non-glomerular chronic kidney diseases, as well as glomerulopathies among themselves. The use of annexin V, an early marker of apoptosis, as a tool for diagnosing chronic kidney diseases and monitoring their progression is not possible at this stage of the study.
RISK ASSESSMENT OF LIPOPROTEIN METABOLISM DISORDERS IN PERSONS AGED 18-39 YEARS
Authors:   Grodno State Medical University, Grodno, Belarus, Belous Yu. I. , Yakubova L. V. ,   Grodno State Medical University, Grodno, Belarus
Published: January 2025

Objective. To develop a method for predicting the risk of developing lipoprotein metabolism disorders in persons 18-39 years of age. Material and methods. 137 healthy young people (33.6% (n=46) boys and 66.4 (n=91) girls) aged 20 [20;21] years were examined. Risk factors for the development of cardiovascular diseases (CVD), physical examination, instrumental and laboratory diagnostics were evaluated. The level of total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins, triglycerides in the blood serum was determined. Results. In the course of the study, a logistic regression model with a binary response and a logit communication function was built, which included the following statistically significant predictors: patient's gender, presence of burdened family history, LDL level and the value of the atherogenicity index. The threshold probability for this model (P0=0.43) was selected based on the results of ROC analysis. The area under the ROC curve was AUC=0.784 (95% CI: 0.689-0.878), sensitivity – 73%, specificity – 70%, classification accuracy – 71%. Conclusion. Risk factors of CVD are quite widespread among young people, and occurs with the same frequency, regardless of age. In young people, the incidence of 3 or more risk factors of CVD was 4.4%. The most significant prognostic factors associated with the development of lipoprotein metabolism disorders in people aged 18-39 years are male sex, the presence of burdened family history, LDL levels and the value of atherogenicity index.
IMPROVEMENT OF HPLC METHODS FOR EVALUATION OF PHENYLALANINE METABOLITES AND FREE AMINO ACIDS IN THE URINE OF CANCER PATIENTS FOR TARGET METABOLOMIC STUDIES
Authors:   Grodno State Medical University, Grodno, Belarus, Doroshenko Ye. M. , Motylevich Zh. V. ,   Institute of Biochemistry of Biologically active compounds of NAS of Belarus
Published: January 2025

Objective: to improve the method for evaluation of compounds in urine characterizing the metabolism of aromatic amino acids which are potentially diagnostically significant in assessing the activity of malignant growth. Methods of study: high-performance liquid chromatography. Results: unique modification of the method for evaluation of phenylalanine metabolites that allows to assess their levels in urine has been created.
ULTRASOUND ASSESSMENT OF THE FUNCTIONAL ACTIVITY OF THE BRACHIAL ARTERY ENDOTHELIUM
Authors:   Grodno State Medical University, Grodno, Belarus, Aleksandrovich A. S.
Published: January 2025

The purpose of this study is a systematic review of modern scientific publications devoted to the assessment of endothelial function. This work analyzes various methods and approaches to this assessment, with emphasis on a test that determines the sensitivity of the brachial artery to shear stresses affecting the endothelium. This test has significant potential for both fundamental research and practical implementation in the field of medicine. The study of the endothelium functional properties plays a crucial role in understanding the pathophysiological mechanisms underlying a number of cardiovascular diseases, including atherosclerosis, hypertension, diabetes mellitus and preeclampsia. The endothelium performs a key function in the regulation of vascular tone, blood clotting processes and the development of inflammation. Therefore, an accurate assessment of its functional state is critically important for the timely diagnosis and development of effective treatments for these diseases. The analysis broadens the understanding of endothelial functions and emphasizes the need to use modern assessment methods in clinical practice. The test to determine the sensitivity of the brachial artery to shear stress on the endothelium can become a valuable tool for medical professionals and researchers, contributing to improving the quality of medical care and developing new treatment strategies.
ПЛОТНОСТЬ ВЕРОЯТНОСТИ ИЛИ ХАРАКТЕРИСТИЧЕСКАЯ ФУНКЦИЯ ЛЯПУНОВА ЛИДЕР В РЕШЕНИИ ЗАДАЧ В СТАТИСТИЧЕСКОЙ ТЕОРИИ ПРИНЯТИЯ РЕШЕНИЙ
Authors: ВЕШКУРЦЕВ Ю М. , ТИТОВ Д А.
Published: January 2025

Открытый в конце 20 века эффект стохастического резонанса в нелинейных системах в настоящее время приобретает широкую известность, число публикаций с его описанием растет. Среди публикаций есть работы, в которых без упоминаний о новом эффекте при исследовании системы высказывалась гипотеза о присутствии какого-то резонанса. Цель данной работы заключается в подтверждении состоятельности гипотез о резонансе, позволившем расширить понимание физических процессов в нелинейной системе и устранить сомнения о достоверности высоких результатов, полученных авторами ранее. Установлено, что характеристическая функция Ляпунова и сопутствующий ей эффект стохастического резонанса могут быть использованы для построения нелинейных систем обнаружения сигнала на фоне шумов. Особое свойство цифрового фильтра на основе характеристической функции Ляпунова проявляется при фильтрации аддитивной смеси сигнала и шума, а также в случаях, когда данный цифровой фильтр используется в составе других устройств, например, в составе блока обнаружения сигнала на фоне шумов.

Discovered at the end of the 20th century, the effect of stochastic resonance in nonlinear systems is now becoming widely known, the number of publications describing it is growing. Among the publications there are works in which, without mentioning a new effect, the hypothesis of the presence of some kind of resonance was expressed during the study of the system. The purpose of this work is to confirm the validity of the hypotheses about resonance, which made it possible to expand the understanding of physical processes in a nonlinear system and eliminate doubts about the reliability of the high results obtained by the authors earlier. It is established that the Lyapunov characteristic function and its accompanying stochastic resonance effect can be used to construct nonlinear signal detection systems against a background of noise. A special property of a digital filter based on the Lyapunov characteristic function is manifested when filtering an additive mixture of signal and noise, as well as in cases when this digital filter is used as part of other devices, for example, as part of a signal detection unit against a background of noise.
Creating innovations for solutions of logistics problems: opportunities, risks, and limitations
Authors: Gorbatov A. I.
Published: January 2025

The article provides an assessment of innovation activity state in logistics companies in the second half of 2022 and 2023 as well as the potential consequences of low level of investment in innovation.

   The relevance of the article is determined by the objective features of the development of the logistics industry in the Russian Federation, primarily in the context of international import and export trade under the conditions of sanctions restrictions as well as increased competition of logistics companies on the market and competitive pressure from international logistics companies which enter the Russian market.

   The purpose of the study is to assess the characteristics of the functioning of the logistics industry and the prospects for its development, which can have a significant impact on the international movement of goods.

   An assessment is made of companies’ strategies to maintain their market share, increasе this share through interaction with the labour market as well as tо use additional tools for obtaining and maintaining a market advantage. A conclusion is drawn about the influence of a number of factor criteria on the further development of the industry and those resources associated with investments in innovation that the company’s owners have for the future development of their business.
ACES-GNN: Can Graph Neural Network Learn to Explain Activity Cliffs?
Authors: Chen Xu , Yu Dazhou , Zhao Liang , Liu Fang
Published: January 2025

Graph Neural Networks (GNNs) have revolutionized molecular property prediction by leveraging graph-based representations, yet their opaque decision-making processes hinder broader adoption in drug discovery. This study introduces the Activity-Cliff-Explanation-Supervised GNN (ACES-GNN) framework, designed to simultaneously improve predictive accuracy and interpretability by integrating explanation supervision for activity cliffs (ACs) into GNN training. ACs, defined by structurally similar molecules with significant potency differences, pose challenges for traditional models due to their reliance on shared structural features. By aligning model attributions with chemist-friendly interpretations, the ACES-GNN framework bridges the gap between prediction and explanation. Validated across 30 pharmacological targets, ACES-GNN consistently enhances both predictive accuracy and attribution quality compared to baseline methods. Our results demonstrate a strong correlation between improved predictions and accurate explanations, offering a robust and adaptable framework for addressing the "intra-scaffold" generalization problem. This work underscores the potential of explanation-guided learning to advance interpretable artificial intelligence in molecular modeling and drug discovery.
Increasing the Accuracy and Robustness of the CHARMM General Force Field with an Expanded Training Set
Authors: Croitoru Anastasia , Kumar Anmol , Lambry Jean-Christophe , Lee Jihyeon , Sharif Suliman , Yu Wenbo , MacKerell Alex , Aleksandrov Alexey
Published: January 2025

Small molecule empirical force fields (FFs), including the CHARMM General Force Field (CGenFF), are designed to have wide coverage of organic molecules and to rapidly assign parameters to molecules not explicitly included in the FF. Assignment of parameters to new molecules in CGenFF is based on a trained bond-angle-dihedral charge increment linear interpolation scheme for the partial atomic charges along with bonded parameters assigned based on analogy using a rules-based penalty score scheme associated with atom types and chemical connectivity. Accordingly, the accuracy of CGenFF is related to the extent of the training set of available parameters. In the present study that training set is extended by 1,390 molecules selected to represent connectivities new to CGenFF training compounds. Quantum mechanical (QM) data for optimized geometries, bond, valence angle, and dihedral angle potential energy scans, interactions with water, molecular dipole moments, and electrostatic potentials were used as target data. The resultant bonded parameters and partial atomic charges were used to train a new version of the CGenFF program, v5.0, which was used to generate parameters for a validation set of molecules, including drug-like molecules approved by the FDA, which were then benchmarked against both experimental and QM data. CGenFF v5.0 shows overall improvements with respect to QM intramolecular geometries, vibrations, dihedral potential energy scans, dipole moments and interactions with water. Tests of pure solvent properties of 216 molecules show small improvements versus the previous release of CGenFF v2.5.1 reflecting the high quality of the Lennard-Jones parameters that were explicitly optimized during the initial optimization of both the CGenFF and the CHARMM36 force field. CGenFF v5.0 represents an improvement that is anticipated to more accurately model intramolecular geometries and strain energies as well as non-covalent interactions of drug-like and other organic molecules.
THE DEPOSITIONAL ENVIRONMENT OF UPPER ȘOMUZ FORMATION REVEALED BY HÂRTOP OUTCROPS
Authors:   Department of Geology, "Alexandru Ioan Cuza" University of Iași 20A Carol I Blv., 700505, Romania, LOGHIN Sergiu ,   National Institute of Marine Geology and Geo-ecology, GeoEcoMar, Bucharest, Romania, SESERMAN Anca Maria ,   Department of Geology, "Alexandru Ioan Cuza" University of Iași 20A Carol I Blv., 700505, Romania, BRÂNZILĂ Mihai ,   Department of Geology, "Alexandru Ioan Cuza" University of Iași 20A Carol I Blv., 700505, Romania
Published: January 2025

Two sedimentary successions from Hârtop (Hârtop A, B), Șomuz drainage basin, revealing middle Miocene (lower Sarmatian sensu lato) of Moldavian Platform deposits were analysed in order to reconstruct the depositional paleoenvironment and the local shoreline behaviour of the Central Paratethys Basin. The studied sections are mainly sandy with few silty and argillaceous interlays. The sedimentary facies analysis led to the separation of 10 sedimentary facies grouped in two Facies Associations (FA), each one describing a typical sedimentary sub-environment. The two identified Facies Associations described the upper shoreface (FA 1) and the lower shoreface (FA 2) typical for a shallow non-deltaic marginal marine depositional environment. The stacking of these facies association suggests a progradational trend of the depositional systems. The micropaleontological assemblages revealed a scarce fauna of shallow water foraminifera and ostracods specific for the neritic area, confirming the basin depth indicated by the sedimentology of the deposits.