bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUATION OF THE EFFICIENCY OF THE LOGISTICS COMPANY'S TRANSPORT PARK
Authors:   Taras Shevchenko national University of Kyiv, Golovanenko M.
Published: January 2022

The article is devoted to the conceptual issues of evaluation of the efficiency of the logistics company's transport park. The information base of the study is data of the real logistics network of one of the leading logistics companies in Dnipro, which has 42 branches. Based on the capabilities of the Google OR-Tools optimization package, a system of optimal transport routes for different fleet options has been built. According to the results of calculations, the transition from vehicles with higher capacity to lower capacity increases the number of passages and the length of the optimal route. Replacing the fleet of the largest load capacity (20 tons) with the smallest (1 ton) leads to considerable increasing of the optimal route’ length. Less capable vehicles are characterized by lower fuel consumption. But the results of calculating the total cost of implementing optimal routes proves that the transition from more capable to less capable vehicles is not effective. Indirect estimation of the efficiency of the combined fleet was built by gradually replacing of the minimum capacity vehicles in the fleet with the maximum capacity vehicles. For each such variant of the fleet, the optimal route was built, its length was recorded and fuel consumption was estimated. Estimation of fuel consumption was carried out by multiplying the length of mileage of large and small-capacity vehicles by the corresponding fuel consumption rates. Prospects for further research are to verify the results using alternative optimization tools. The results of the analysis indicate the effectiveness of building a transport fleet of logistics company based on heavy-duty vehicles. This approach reduces the number of pendulum routes and minimizes fuel consumption through the use of ring routes.
SMM AS A TOOL OF COMPETITIVENESS OF THE ENTERPRISE IN THE CONDITIONS OF MODERN CHALLENGES
Authors:   Taras Shevchenko national University of Kyiv, Lytvynenko T. , Yevchenko S. ,   Taras Shevchenko national University of Kyiv
Published: January 2022

The activities of modern enterprises are affected by both new opportunities and challenges. An example of the challenges for global business was the spread of the COVID-19 pandemic and related quarantine restrictions. The negative macroeconomic and microeconomic consequences of the pandemic significantly worsened the financial and economic situation of enterprises, led to changes in consumer behavior. Businesses are forced to look for tools to stimulate economic development and increase competitiveness. The development of scientific and technological progress, digitalization make available the use of Internet technologies, in particular in the field of marketing. In Ukraine, as well as around the world, Internet marketing is becoming widespread. At the same time, the possibilities of such an innovation as social media marketing have not yet been properly implemented. Social networks have been created as a tool of entertainment; have become a powerful tool for marketing. They play an important role in establishing business relationships with customers. Social media in today's environment is more popular than traditional media. The use of SMM accelerates the sale of products and services, reduces marketing costs and better implementation of all marketing processes. Social networks allow you to quickly find people depending on interests, age and other parameters, create groups and inform potential consumers about various new products. Advertising on social networks is usually not as intrusive as on other resources and is targeted to a target audience, which is selected by a large number of parameters. To confirm the thesis that SMM is an important tool for the competitiveness of the enterprise in today's challenges, a study was conducted on the basis of the cheese brand - TM "Laguna" of the company "Food Production Ukraine". Analysis of the results of the study showed that "Laguna" in the eyes of consumers is associated with an inexpensive product of relatively low quality, with a "copy" of well-known global brands and loses to them in sophistication. . Given the limited use of offline marketing in quarantine, it was decided to develop a set of actions to influence the consumer through Internet resources. Improvements in SMM have ensured that people are sympathetic to the manufacturer and the product itself.
DEVELOPMENT OF SOCIAL ACCOUNTING: PROSPECTS AND CHALLENGES
Authors:   National University of Life and  Environmental Sciences of Ukraine, Hutsalenko L.V. , Mulyk T.O. ,   Vinnytsia  National Agrarian University, Myskiv L.P. ,   National University of Life and  Environmental Sciences of Ukraine
Published: January 2022

The article considers the relationship between the concept of corporate social responsibility and the concept of sustainable development. The three most important components of enterprises under conditions of sustainable development, economic, social and environmental, have been identified. Emphasis is placed on the peculiarities of the formation of the maximum flow of total income in the economic approach. It is outlined that from the ecological point of view, sustainable development should ensure the integrity of biological and physical natural systems. The social component of the stability of the development of the economic entity is focused on people and is aimed at maintaining the stability of social and cultural systems, in particular, to reduce the number of destructive conflicts between people. It is generalized that an important aspect of this approach is the fair distribution of benefits. It is stated that social responsibility involves maintaining social records, preparing and publishing non-financial statements, which allows you to document the implementation of social tasks, which is indirectly or incompletely reflected in the accounting system. The types of social accounting (Social Responsibility Accounting (SRA), Aggregate Impact Accounting (SEA), Socio-Economic Accounting (SIA), Social Performance Accounting (SA)) are presented and their characteristics are given. The norms of international standards (AA1000, ISO 26000) regulating the international practice of social responsibility of business are given. The evolution of the formation of social responsibility reporting is outlined. The dynamics of the number of business entities of Ukraine that submit reports in accordance with the GRI is given. The peculiarities of the formation of the components of social accounting in economic entities are outlined. It is expedient for large enterprises to distinguish stages: planning (identification stage), accounting (determining the scope and setting up a social accounting system), reporting and auditing (collecting and providing information to an independent audit company). For medium and small enterprises it is advisable to distinguish the following steps: scope of activities (study of key elements of the enterprise), accounting (design and maintenance of social accounting system), reporting (reporting to interested users).
BLOCKCHAIN IN PUBLIC SECTOR
Authors:   Taras Shevchenko national University of Kyiv, Diakiv A.
Published: January 2022

The Internet has radically transformed access to and exchange of information, and it plays a fundamental role in today's society and economy. Yet it was difficult to imagine all the services offered today when the first tools necessary for its democratization were introduced thirty years ago. The blockchain, since the publication of the white paper of bitcoin as the first digital asset, has considerably broadened the range of its fields of application and its potential use cases in ten years; it could play, in different forms, a role comparable to that of the Internet in an area that the latter does not cover: trusted IT and legal transactions. Indeed, while the Internet is the privileged vehicle for the exchange of all digitized forms of information, it is not the guarantor, as a network infrastructure, of its uniqueness or its functioning. Blockchain technology has evolved from a niche subject to the hottest tech disruption buzzword, but there is still a lot of confusion about the subject. Without a clear understanding about what Blockchains are, their potential public sector potential impact is sometimes misunderstood or, more often, ignored. Questions related to their technical complexity, risk, security, and appropriateness often serve as obstacles to government officials’ ability to truly engage with this emerging technology. In this article, we consider the key features and types of blockchain technology and describe the potential use of blockchain technology in the public sector. In general, the blockchain can be used in the public sector to address the following tasks: authentication, traceability and uniqueness. We have identified ten potential directions of using blockchain technologies in public sector: self-sovereign identity, contract and vendor management, notarization, aid management, secure data sharing, financial services and banking, voting, verifiable diplomas and certificates, energy utilities, copyrights.
TRENDS AND PROSPECTS OF ROAD ECONOMY DEVELOPMENT IN UKRAINE
Authors:   Taras Shevchenko national University of Kyiv, Shmaliy N.
Published: January 2022

The importance of road management for the economy and the state as a whole is determined. Developed transport infrastructure and highways are the key to a developed society and the efficient functioning of the economy of any state. According to the latest estimates of the Ministry of Infrastructure, the technical and operational condition of roads meets modern requirements for strength and equality by only 39.2% and 51.1%, respectively, due to the crisis in budget funding, insufficient maintenance of infrastructure, backwardness of technologies in the field of construction, which in turn causes economic and environmental losses in other sectors of the national economy. The main problems that damage the development of the road industry include: non-compliance of road coverage with European standards and traffic intensity, road wear, reduced road safety, poor quality of road repairs, poor control and others. The article examines the state, trends and prospects of road development in Ukraine. The main participants and the hierarchy of road users and the functions they perform are described. The structure of state and local roads of Ukraine is analyzed. In accordance with the Law of Ukraine № 1762 "On Amendments to the Law of Ukraine" On Sources of Financing of the Road Industry of Ukraine "to improve the financing mechanism of the road sector" and № 1763 "On Amendments to the Budget Code of Ukraine to improve the mechanism of financing the road sector" funds to finance the construction, reconstruction and repair of roads of national importance in 2020, 2021. On the basis of legislative documents and the National Transport Strategy, the main directions of the industry development are highlighted. Sources of financing of the Road Fund are established. It should be noted that this is not only revenue from the state budget, but also active involvement
Public Policy Issues Affecting Integrated Health Care: Challenges, Opportunities, and Implications for Clinical Mental Health Counselors
Authors: Kaur Varinder , Lindinger-Sternart Sylvia , Grey Brittn
Published: January 2022

The growing need for the treatment of the whole person creates an opportunity for establishing a holistic integrated health care (IHC) system in various clinical settings. Considering the issues with existing IHC models and related public policies, and the current barriers facing clinical mental health counselors (CMHCs) who hope to become an integral part of IHC teams, we propose a new holistic IHC model. We highlight several practical implications of our proposed model that could be beneficial for the development of professional identity of CMHCs and their inclusion in IHC teams. We also offer numerous propositions for improving IHC-related policies in favor of CMHCs and the counseling profession.
Ethical Standards for a Post-COVID-19 World
Authors: Mifsud Anabel , Herlihy Barbara
Published: January 2022

The cataclysmic events of 2020 created an urgent need for mental health counseling to help individuals, families, and communities deal with grief, loss, and trauma. The sheer magnitude of the challenges has highlighted the necessity for collective interventions, as the need for help far surpasses what can be met through traditional individual or family counseling. Clinical mental health counselors must be prepared to respond to the new challenges in creative, culturally responsive, and ethical ways. The authors discuss the limitations of the prevailing codes of ethics, which are grounded in principle ethics, and propose that virtue ethics and relational ethics perspectives can be incorporated into ethical reasoning to make the process more responsive to collective interventions. A case scenario is presented and analyzed to illustrate this broader and more inclusive approach to ethical decision-making in a situation that calls for a collective intervention.
The study of the efficiency of micropulse transscleral cyclophotocoagulation in the combined treatment of patients with secondary neovascular glaucoma
Authors: Sidorova Alla V. , Starostina Anna V. , Pecherskaia Mariia A. , Khabazova Margarita R. , Arisov Alexey A.
Published: January 2022

Background: Neovascular glaucoma (NVG) is a highly refractory form, it is characterized by fast development and a high level of the intraocular pressure (IOP).
Aims: To evaluate the effectiveness of micropulse transscleral cyclophotocoagulation (mCPC) in the combined treatment of patients with secondary neovascular glaucoma.
Methods: The study included 32 patients (32 eyes) with secondary NVG as an outcome of diabetes mellitus and (or) thrombosis of the central retinal vein or its branches. The preoperative IOP averaged 38.88.8 mm Hg with the most intense hypotensive therapy. All the patients underwent mCPC. In the postoperative period, the patients were examined on the first day after the operation, then in 1 week, 1, 3, 6 months, 1 year after the operation.
Results: All the operations were performed without complications. Pain syndrome in all cases was stopped on the first day after surgery. Six patients had reactive hypertension on the first day, therefore, the hypotensive therapy was intensified. The IOP 1 week after mCPC was 20.97.9 mm Hg, after 1 month of observation 23.76.0 mm Hg with the hypotensive therapy. 34 weeks post-surgery, six patients with the preserved visual function experienced a repeated IOP increase, and the Ahmed valve was implanted. 6 months after mCPC, the IOP level averaged 22.87.7 mm Hg with the hypotensive therapy. Against the background of the IOP compensation, anti-VEGF drugs were injected in 4 cases, followed by laser coagulation of the retina.
Conclusion: Application of mCPC in NVG glaucoma patients showed only a small number of postoperative complications. This method of laser treatment can be used in combination with panretinal laser coagulation before or after the surgery, including administration of anti-VEGF drugs before or after the surgery. In case of the IOP increase, mCPC may be repeated.
A clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancer
Authors: Berishvili Aleksander I. , Ivanov Yuri V. , Lebedev Dmitry P. , Zabozlaev Fedor G. , Kravchenko Edward V. , Klypa Tatiana V. , Kedrova Anna G.
Published: January 2022

Background: Giant tumors of the abdominal cavity, as a rule, occur in elderly patients with characteristic features and represent a serious problem in terms of choosing a radical method of therapy. Of particular difficulty are cases of giant serous endometrial cancer, requiring a differential diagnosis with ovarian cancer.
Clinical case description: A clinical case of giant serous endometrial cancer mimicking ovarian cancer in a 55-year-old woman is presented. The patient came to the oncology department with complaints of abdominal enlargement, difficulty breathing and bloody discharge from the genital tract. The examination revealed the following: a giant formation (4065 cm), occupying the entire pelvic and the entire abdominal cavities, ascites, lesions of the retroperitoneal lymph nodes, and the greater omentum, an umbilical hernia. A chest CT showed multiple contrast-accumulating circular shadows of 313 mm (metastases). By the decision of the council, after the preliminary chemoembolization of both the uterine and ovarian arteries, a supravaginal amputation of the uterus with appendages was performed, along with the resection of the greater omentum, removal of the umbilical hernia with positioning a plastic mesh implant and excision of an excess skin flap. The histological examination of the intraoperative material made it possible to verify the diagnosis of a serous endometrial carcinoma with subtotal tumor necrosis, the myometrium invasion of more than a half of its thickness, with the egress to the perimetrium, metastatic lesions of both ovaries, the greater omentum, anterior abdominal wall. Stage T3b (FIGO IIIB). In the postoperative period, 6 courses of Paclitaxel / Carboplatin (AUC4-5) chemotherapy were carried out with a pronounced clinical effect. The patient was discharged in a satisfactory condition. The control PET-CT scan after the 6th chemotherapy course showed no pathology in the thoracic cavity, and no process progress in the abdominal cavity. Currently, the remission of the disease is 9 months.
Conclusion: An algorithm for the diagnostic measures aimed at making the correct diagnosis is presented, and the tactics of treating a patient with giant serous endometrial cancer is described.
A case of hysteria with prolonged spontaneous periods of catalepsy
Authors: Donskov N. A.
Published: January 2022

Among the very diverse symptoms in which hysteria is expressed, one of the largest places is occupied by dream-like states and, mainly, those that arise spontaneously, and not under the influence of hypnosis, although they are not very common. Such conditions are known to include catalepsy, lethargy, and somnabulism. One of these states I had to observe partly in the Kazan provincial zemstvo hospital, partly in the Kazan District Hospital.
Objective psychology. Academician V. Bekhterev. Issue I. St. Petersburg. 1907 year
Authors: Osipova V.
Published: January 2022

The author begins his work with the words that the psychology that he will expound bears little resemblance to the psychology that has been the subject of study until now. In objective psychology, there should be no place for questions about subjective processes or processes of consciousness, therefore there should be no place for introspection. Self-observation is not enough even to study one's own mental life. Objective psychology has in mind to study and explain only the relationship of a living creature to the surrounding conditions that affect it in one way or another, without aiming to find out those internal or subjective experiences, which are known as conscious phenomena and which are accessible only to self-observation. All mental items should only be subject to objective registration and control.
Frequency of endemic goiter and indicators of pituitary-thyroid profile in Arctic children
Authors: Evseeva S. A. , Burtseva T. E. , Klimova T. M. , Danilov N. A. , Chasnyk V. G. , Douglas N. I.
Published: January 2022

Objective. Analysis of the frequency of endemic goiter and indicators of the pituitary-thyroid profile in children aged 10-18 years living in the Arctic regions of Yakutia. Materials and methods. The study was conducted among children and adolescents of the Arctic regions of Yakutia (Bulunsky, Anabarsky, Allaikhovsky, Nizhnekolymsky, Verkhnekolymsky district) during field medical expeditions in 20182020. A total of 392 children aged 1018 years were examined. Results. In 30 % of the examined children, an increase in the thyroid gland was observed, which was accompanied by elevated levels of free thyroxine. In 3 % of children, an increase in the level of thyroid-stimulating hormone was detected against the background of reduced or normal levels of free thyroxine. Conclusions. As for the prevalence of cases of endemic goiter, the Arctic regions of Yakutia are the areas of severe goiter endemia. The results obtained justify the need for additional scientific studies to assess the degree of iodine availability (by the concentration of iodine in the urine) in different population groups and real implementation of the strategy of mass preventive measures.
Study of genes involved in angiogenesis and metabolic processes of peripheral blood lymphocytes in patients with chronic endometritis
Authors: Kobaidze E. G.
Published: January 2022

Objective. To study the polymorphisms of the genes involved in angiogenesis and in metabolic processes, to assess the level of lymphocytes in patients with chronic endometritis and practically healthy women of reproductive period.
Materials and methods. 86 patients were examined; DNA regions of the genes eNOS 1799983 (Glu298Asp), PPARA (G2528C), ApoE rs429358 (Cys130Arg), MTHFR (C677T, A1298C) were used as primers; blood lymphocytes (CD3+, CD4+, CD8+, CD19+, CD95+) were assessed.
Results. Statistically significant differences in gynecological and chronic somatic pathology were obtained in patients with chronic endometritis; they more often than practically healthy women had polymorphisms of the genes ApoE rs429358, eNOS1799983, PPARA (G2528C); patients with chronic endometritis more often had dysregulation of the immune system in the form of insufficiency of the cellular effector link of immunity and changes in the PPARA, ApoE, eNOS gene. Attention was drawn to the obtained relationships of polymorphic genes and clinical manifestations in patients with chronic endometritis, in particular, with a history of non-developing pregnancy in anamnesis, there was more often detected polymorphism of the ApoE gene, with abnormal uterine bleeding polymorphism of PPARA, with chronic inflammatory pathology of the gallbladder polymorphism of the MTHFR gene.
Conclusions. The prevalence of polymorphism of the genes eNOS 1799983 (Glu298Asp), PPARA (G2528C), ApoE rs429358 (Cys130Arg), MTHFR (C677T, A1298C) was obtained in patients with chronic endometrial inflammation compared with practically healthy participants in the study. Insufficiency of the cellular effector link of immunity was revealed in the majority of patients with ChE and an association with allele C genotypes G/C and C/C of PPARA 4253778 gene, with allele C genotypes G/C and C/C of ApoE42935 gene, with allele C genotypes G/C and C/C of eNOS 1799983 gene and G/C genotype of MTHFR gene (C677T, A1298C).
Features of the course of myocardial infarction without coronary artery obstruction
Authors: Maksimov N. I. , Grishin I. S.
Published: January 2022

Objective. To study the clinical and laboratory features and the early post-infarction period in patients suffering from myocardial infarction with non-obstructive coronary arteries (MINOCA).

Materials and methods. A survey of 62 patients hospitalized to the Republican Clinical and Diagnostic Center of the Ministry of Health of the Republic of Udmurtia with a diagnosis of "myocardial infarction" was conducted, 30 of whom had a single-vessel lesion of the coronary bed, 32 myocardial infarction without coronary artery obstruction.

Results. Differences in the clinical manifestations of the acute period were noted by the presence of syncope, isolated shortness of breath, and a difficult-to-explain feeling in the chest. The time from the onset of symptoms to hospitalization in the MINOCA group exceeds 1.7 hours. The MINOCA group had a much higher level of markers of myocardial necrosis (troponin I level of 8.9 ng/ml compared to 1.75 ng/ml), despite a significantly lower frequency of detection of hypokinesia zones and the number of affected segments.

Conclusions. It is necessary to improve public awareness of the symptoms of acute coronary syndrome, including its atypical manifestations. Routine PCI does not "save" from subsequent angina pectoris if it is present before MI.
Normal concentration of oral fluid procalcitonin and concentration in periodontitis
Authors: Gileva O. S. , Mandra Yu. V. , Sivak E. Yu. , Polushina L. G. , Libik T. V. , Мaksimova A. Yu. , Sosnin D. Yu.
Published: January 2022

Objective. To study the procalcitonin concentration (PCC) in the oral fluid of healthy persons and patients with periodontitis.
Materials and methods. The procalcitonin concentration was studied in the oral cavity of 42 patients with periodontitis (main group) and 25 patients with sanitized oral cavity (comparison group).
Results. The result medians in the comparison group by 1.658 times exceeded the median in the main group (р = 0,004315) and made up for the main group 114 (64; 144) pg/ml and for the comparison group 189 (117; 485) pg/ml. No differences in the oral fluid PCC concentration between men and women (p = 0,052) were revealed. There was not observed the dependence of the PCC content in the saliva on the age of the examined persons (R = 0.208).
Conclusions. The decrease in the oral fluid PCC concentration can be induced by the decrease in the bacterial load due to preliminary sanation of the oral cavity and dilution of the saliva as a result of activation of exudation and salivation processes in periodontium tissue inflammation.
Analysis of L-carnitine effectiveness in complex treat-ment of pregnant women with placental insufficiency
Authors: Mamedli G. H. , Babaeva G. I. , Azizova M. E. , Sirajli U. M. , Hajizade G. G.
Published: January 2022

Objective. To increase the effectiveness of treatment of placental insufficiency in pregnant women with the inclusion of L-carnitine (Inestom) in complex therapy.

Materials and methods. A total of 76 pregnant women aged 18 to 39 years were examined at 2240 weeks of gestation. All the examined patients were divided into two groups. Patients of the first group (n = 37) received only basic treatment, which included the use of a complex of vasodilators, tocolytics, drugs that improve microcirculation and rheological properties of blood. Patients of the second group (n = 39) received L-carnitine along with basic therapy (Inestom, Help SA Pharmaceuticals, Greece).

Results. The use of the drug Inestom as a part of the complex treatment of placental insufficiency led to the normalization of utero-placental-fetal blood flow and intrauterine fetal development in 94.7 % of pregnant women. After the course of drug therapy, there was an increase in the total score of cardiotography, which in the first group of patients was 7.08 0.06 before treatment and 7.13 0.11 after treatment (p 0.05), and in the second group 7.12 0.11 before treatment and 7.95 0.05 after (p 0.05). The results of antenatal dopplerometry showed that in pregnant women who received Inestom as a part of the complex treatment, there was a decrease in the mean values of all vascular resistance indices.

Conclusions. The use of Inestom in the complex treatment of placental insufficiency has a positive effect on the state of hemodynamics in the "mother-placenta-fetus" system, and affects the intrauterine state of the fetus.
Associative influence of new coronavirus infection SARS-CoV-2 during pregnancy on formation of neurological disorders in newborns: clinical case
Authors: Shevlyukova T. P. , Zhusupova Zh. K. , Solovyeva E. N.
Published: January 2022

The Severe Acute Respiratory Syndrome caused by Coronavirus-2 (SARS-CoV-2) has a destructive impact on the population all over the world. In this scenario, the extent, to which the disease will affect more vulnerable individuals, such as pregnant women, is a major concern. Since pregnancy can be a risk factor for respiratory viral infections, there are significant differences regarding the severity of COVID-19 between pregnant and non-pregnant women. In these circumstances, there arises a serious problem associated with the possibility of harm to the health and neuropsychiatric development of the posterity of infected mothers. The acute inflammatory response observed during the disease can lead to several types of nervous system disorders in the newborn. In the light of neuroimmune interactions on the mother-fetus hematoplacental relationship, a clinical case is described that reflects the consequences for the nervous and psychoneurological development of the newborn from SARS-CoV-2 infected mother.
Epidemiological manifestations of respiratory system diseases among military personnel of central military region
Authors: Mukhachev Ivan S. , Feldblium Irina V. , Stolyarov Dmitriy A. , Alyeva Maya Kh.
Published: January 2022

Objective. To assess the epidemiological manifestations of the incidence of respiratory system diseases (RSD) among the military personnel of the military units of the Central Military Region. Materials and methods. The morbidity analysis was carried out according to official statistics for 20032019 with an assessment of long-term dynamics, structure and spatial characteristics. Results. Despite the preventive measures taken, the incidence of respiratory diseases in the troops remains high and continues to grow. The conscript servicemen are at risk. In the structure of RSD incidence, acute respiratory viral infections (ARVI) take the leading place, tonsillitis and bronchitis are in the second place, and community-acquired pneumonia (CAP) is in the third place. Differences in the trends of long-term dynamics of morbidity in various clinical forms of RSD were revealed. The Siberian Federal Region is the most favorable regarding RSD incidence. Conclusions. The incidence of respiratory diseases among conscripts is higher than that in contract servicemen, with downward trend for CAP and growth for ARVI and bronchitis.
Results of a six-year prospective study of surgical treatment of patients with combined atherosclerosisof coronary and brachiocephalic arteries based on differentiated approach
Authors: Marchenko A. V. , Vronskiy Alexey S. , Myalyuk P. A. , Oborin A. A. , Minasyan V. N. , Lazarkov P. V. , Sinelnikov Yu. S.
Published: January 2022

Objective. To present the results of surgical treatment of patients with multifocal atherosclerosis based on a differential approach of surgical strategy.
Materials and methods. During the period of 20142021 in the S.G. Sukhanov Federal Center for Cardiovascular Surgery, Perm, we operated 243 patients with combined atherosclerosis of coronary and carotid arteries; 104 (42.8 %) patients underwent a one-stage coronary and carotid artery surgeries, and 139 (57.2 %) patients underwent a staged correction of pathology. Critical lesion of the coronary arteries was revealed in 16 (6.6 %) patients, single-vessel critical lesion in 24 (9.9 %), two-vessel and three-vessel critical lesion was detected in 87 (35.8 %) and 79 (32.5 %) patients, respectively. 145 (59.7 %) patients had a critical lesion of the carotid arteries, and 16 (6.58 %) had a bilateral critical lesion. We have developed an algorithm for choosing treatment tactics in patients with concomitant atherosclerotic lesions of the coronary and carotid arteries. Depending on our differential approach, we selected 104 (42.8 %) patients who underwent a one-stage surgery, and 139 (42.8 %) patients who were subjected to a staged treatment.
Results. A total hospital mortality was 0 %. In the staged group, 1 case of transitory ischemic attack (TIA) (0.7 %) was recorded, in the group of combined interventions there was no TIA. In the group of combined interventions, there were 3 (2.9 %) cases of the perioperative stroke and 1 (0.9 %) case of myocardial infarction. In the group that underwent staged interventions, there were 2 (1.4 %) cases of perioperative stroke and 2 (1.4 %) cases of myocardial infarction. Both groups had similar combined results (death, acute MI, stroke) 5 (3.6 %) for the staged group and 4 (3.8 %) for the combined one. There was no significant difference in any of the endpoints.
Conclusions. The proposed approach to the choice of techniques for treatment of combined lesions of the carotid and coronary arteries based on the differential approach is safe and permits to adequately eliminate the lesions.
Role of matrix metalloproteinases in placental angiogenesis
Authors: Sadykova G. K. , Olina A. A.
Published: January 2022

The literature data indicate that the impaired expression of some types of metalloproteinases can result from different causes, both endogenous and exogenous. A modern notion of the role of matrix metalloproteinases in the processes of placental angiogenesis is analyzed. There was used literature research method according to the database PubMed for 19942021. The study of the activity and function of metalloproteinases in various gestational complications associated with the formation of primary placental insufficiency could have helped to search the diagnostic markers of these disorders.
Assessment of genes in defective integrated HIV-1 provirus within the PBMC compartment of individuals with neuroHIV
Authors:   , De Souza Diehl Remedio , Somarowthu Srinivas , Nonnemacher Michael R.
Published: January 2022

The integrated human immunodeficiency virus type 1 (HIV-1) provirus forms a stable but transcriptionally silent viral reservoir in the host. Studies have also shown that this viral reservoir contains both replication-competent and defective-proviral sequences. At least some defective proviruses may still be able to produce viral proteins which may contribute to chronic HIV-1 pathogenesis and disease. We have previously studied genetic variation associated with the expression of the viral accessory protein Tat in an attempt to link this variation to functional outcomes. Sequencing of the HIV-1 genome showed an approximate 40 percent failure rate in amplifying the tat gene region. This could be due to genetic variation at the site of the PCR primer complementarity, low HIV-1 target genome copies in the peripheral blood mononuclear cell (PBMC) population, or a lack of target due to defective provirus. We hypothesized that the reason for such variable results could be due to accumulation of replication incompetent defective proviruses. Given these observations, we used a near-full length (NFL) PCR amplification strategy to examine the full spectrum of integrated proviruses contained within the PBMC compartment of individuals in the absence or presence of neuroHIV. The HIV protein Tat has been linked to cause neuropathogenesis on its own. Tat is the only viral regulatory protein detectable in therapy-controlled individuals. Tat has also been shown to be made in latently infected cells. Given this, we hypothesized that the more the tat gene was present, the more likely it could be for the individual having neurocognitive impairment. Amplicon analyses were conducted utilizing a third-generation sequencing (TGS) platform, Nanopore's MinION. Initial results showed defective virus as the predominant species in most individuals. Further analysis showed a trend toward tat gene presence correlating to neurocognitive impairment.
Impact of Government and International Organizations on Food Security Policy in Poland
Authors: Słapczyński Tomasz Marcin
Published: January 2022

W artykule podjęto próbę zbadania, w jaki sposób organizacje międzynarodowe i ich polityka wpływają na proces podejmowania decyzji dotyczących polskiej polityki bezpieczeństwa żywnościowego. Czy stanowią one bodziec dla podejmowanych decyzji, czy są one uzupełnieniem już istniejącej polityki rządu dotyczącej food security. Główne pytana badawcze dotyczy tego czy narodowa polityka food security jest na zadowalającym poziomie czy niezbędne jest jednak uzupełnienie jej poprzez ingerencję organizacji międzynarodowych. Artykuł podzielony jest na kilka akapitów: polska narodowa strategia żywnościowa, wpływ Unii Europejskiej na bezpieczeństwo żywnościowe Polski i działania organizacji na bezpieczeństwo żywnościowe w Polsce, stosowane metody badań polityki bezpieczeństwa żywnościowego w Polsce, analiza sektora rolnego w Polsce oraz ogólne analiza polityki bezpieczeństwa żywnościowego w Polsce. Zdefiniowano podstawowe pojęcia związane z polityką, porządkiem publicznym i bezpieczeństwem żywnościowym. Opisano również rolę różnych organizacji w rozwoju bezpieczeństwa żywnościowego. Scharakteryzowane zostaną także indywidualne działania podejmowane przez organizacje międzynarodowe i rząd w celu zwiększenia bezpieczeństwa żywnościowego.
Pengaruh kecerdasan emosional dan kecerdasan sosial terhadap kinerja karyawan promotor produk pada PT. Blue Ocean Heart Kota Malang
Authors: Wahyudi Eko , Nora Elfia
Published: January 2022

This study aims (1) to determine how the description of emotional intelligence, social intelligence, and employee performance, (2) to determine the effect of emotional intelligence on employee performance, (3) to determine the effect of social intelligence on employee performance. This research was conducted on 51 employees at a company engaged in the distribution or sales of Vivo smartphones in Malang, namely PT. Blue Ocean Heart, Malang city. The sampling technique in this study was the sample random sampling technique, and the data analysis technique used in this study was descriptive statistical techniques and multiple linear regression. The results of this study indicate: (1) the level of emotional intelligence, social intelligence, and employee performance is in the good or smart category, (2) emotional intelligence has a positive and significant effect on employee performance, (3) social intelligence has a positive and significant effect on employee performance.

Penelitian ini bertujuan (1) untuk mengetahui bagaimana deskripsi kecerdasan emosional, kecerdasan sosial, dan kinerja karyawan, (2) untuk mengetahui pengaruh kecerdasan emosional terhadap kinerja karyawan, (3) untuk mengetahui pengaruh kecerdasan sosial terhadap kinerja karyawan. Penelitian ini dilakukan terhadap 51 orang karyawan pada perusahaan yang bergerak dalam bidang distribusi atau penjualan smartphone Vivo di kota Malang yaitu PT. Blue Ocean Heart kota Malang. Teknik pengambilan sampel dalam penelitian ini adalah teknik sample random sampling dan analisis teknik analisis data dalam penelitian ini menggunakan teknik statistik deskriptif dan regresi linier berganda. Hasil penelitian ini menunjukkan: (1) tingkat kecerdasan emosional, kecerdasan sosial, dan kinerja karyawan masuk dalam kategori baik atau cerdas, (2) kecerdasan emosional berpengaruh positif dan signifikan terhadap kinerja karyawan, (3) kecerdasan sosial berpengaruh positif dan signifikan terhadap kinerja karyawan.
Pengembangan E-modul berbantuan aplikasi Flip Builder pada mata pelajaran marketing (Studi pada kelas x bisnis daring dan pemasaran SMKN 1 Turen)
Authors: Cahyani Agustin Eva , Dwi Kusumajanto Djoko , Dian Wahyudi Handri , Hidayat Rachmad
Published: January 2022

Perkembangan ilmu pengetahuan dan teknologi yang semakin berkembang diperlukan seorang guru lebih kreatif dan inovatif dalam menyusun bahan ajar sesuai dengan perkembangan teknologi dalam dunia pendidikan. Salah satu diantara perkembangan teknologi didunia pendidikan adalah e-modul. Berdasarkan hasil observasi serta wawancara dengan guru mata pelajaran Marketing di SMKN 1 Turen, diperoleh informasi bahwa media pembelajaran yang dilakukan dikelas yaitu papan tulis, power point, LCD serta handout sebagai sumber belajar yang dibagikan setiap pembelajaran. Penelitian dan pengembangan ini bertujuan untuk: (1) Menghasilkan produk media e-modul berbantuan aplikasi Flip Builder. (2) Mengetahui kelayakan produk e-modul Marketing berbantuan Flip Builder. (3) Mengetahui respon siswa terhadap media e-modul Marketing berbantuan aplikasi Flip Builder pada mata pelajaran Marketing siswa kelas X Bisnis Daring dan Pemasaran SMKN 1 Turen. Metode penelitian dan pengembangan yang digunakan dalam penelitian ini adalah model penelitian dan pengembangan (R&D) Borg & Gall yaitu: Potensi dan masalah, Pengumpulan data, Desain produk, Validasi desain, Revisi desain, Uji coba Produk, Revisi produk 1, Uji coba pemakaian, Revisi produk 2 dan Produk akhir. Subjek penelitian ini adalah siswa kelas X Bisnis Daring dan Pemasaran 3 SMKN 1 Turen dengan jumlah siswa 35 orang. Hasil penelitian media e-modul berbantuan aplikasi Flip Builder yaitu: Hasil validasi ahli media sebesar 96% yang memperoleh kriteria sangat valid dan layak diuji cobakan di lapangan. Hasil validasi ahli materi 1 sebesar 76% dan ahli materi 2 sebesar 73% yang memperoleh kriteria cukup valid dan dapat digunakan dengan revisi. Hasil validasi siswa uji terbatas sebesar 86,25% dengan kriteria sangat positif sedangkan uji coba lapangan didapatkan rata-rata 91,07% yang berarti kategori respon siswa sangat baik. Sehingga dapat disimpulkan e-modul berbantuan Flip Builder sangat layak untuk digunakan dalam kegiatan pembelajaran. Saran untuk pengembangan e-modul berbantuan aplikasi Flip Builder selanjutnya yaitu : (1) Materi yang disajikan dalam e-modul dapat di ubah sesuai perkembangan jaman, (2) Dapat merancang media pembelajaran dengan konten warna, gambar, animasi,serta tema yang lebih baik lagi. (3) E-modul berbantuan aplikasi Flip Builder dapat dikembangkan pada mata pelajaran lainnya.
Pengembangan E-modul berdasarkan aplikasi Pdf Flipbook untuk meningkatkan kemampuan menulis dan kemampuan belajar mandiri peserta didik (E-module based on the corporate Pdf Flipbook application which is useful in the Covid-19 era)
Authors: Nanda Safitri Sania , Churiyah Madziatul , Arief Mohammad , Zen Fadia
Published: January 2022

Perkembangan pendidikan era globalisasi ditandai dengan berbagai macam produk teknologi informasi seperti modul cetak menjadi E-Modul. Dimasa pandemi virus Covid-19 pembelajaran yang semula dilakukan secara tatap muka langsung, pemerintah mengeluarkan kebijakan pembelajaran diubah secara daring dalam rangka menghindari penyebaran Covid-19. Bahan ajar yang semula modul cetak mengalami perkembangan menjadi E-Modul, dimana pembelajaran dilakukan secara Online yang lebih dikenal dengan Pembelajaran Jarak Jauh (PJJ) yakni peserta didik mengikuti proses pembelajaran melalui pembelajaran daring di rumah masing-masing. Sehingga penelitian ini bertujuan untuk menghasilkan E-Modul berbasis Aplikasi Flipbook PDF Corporate yang dapat dioperasikan menggunakan Laptop/PC atau Smartphone di perangkat pendidik dan peserta didik. Penelitian dan pengembangan ini menggunakan (Research and Development / R&D) dari Borg and Gall yang telah dimodifikasi dan disesuaikan dengan kebutuhan penelitian. Instrumen pengumpulan data terdiri dari 2 jenis, yaitu data kuantitatif dan data kualitatif. Data kuantitatif berupa angket dan data kualitatif berupa wawancara, kritik dan saran. Teknik analisis data hasil belajar psikomotorik menggunakan SPSS versi 24, yaitu uji Independent Sample T-tes untuk mengetahui perbedaan hasil belajar aspek psikomotorik pada keterampilan menulis surat peserta didik. Hasil penelitian dan pengembangan ini adalah E-Modul berbasis Aplikasi Flipbook PDF Corporate yang dapat dioperasikan menggunakan Laptop/PC atau Smartphone di perangkat pendidik dan peserta didik pada mata pelajaran Korespondensi yang telah dinyatakan valid dan layak digunakan dalam pembelajaran Korespondensi oleh ahli materi, ahli E-Modul, dan 6 siswa uji coba kelompok kecil serta terbukti dapat meningkatkan keterampilan menulis surat dan kemandirian belajar secara signifikan pada uji coba kelompok besar. Sehingga dapat disimpulkan E-Modul berbasis Aplikasi Flipbook PDF Corporate layak dan efektif digunakan sebagai media pembelajaran untuk meningkatkan keterampilan menulis surat dan kemandirian pada mata pelajaran Korespondensi.
Pendidikan ekonomi dalam keluarga pemilik home industry Desa Jatimalang Kecamatan Klirong Kabupaten Kebumen
Authors: Purwaningrum Aryani , Wahyono Hari
Published: January 2022

Abstract

This study aims to look at economic education in the family carried out by parents to children. All parents have taught family economic education in different ways. The importance of economic education in the family is to form children to use money rationally. As for economic education in the family, namely modeling, habits, discussion and communication, and consumption rationality. Researchers used qualitative research methods with a phenomenology approach. The technique used in this research is purposive sampling. The data technique is done by observing, interviewing and documenting. Parents' awareness to teach economic education in the family is high. By doing intense learning and full motivation from parents, children will quickly understand and apply it in everyday life.

Abstrak

Penelitian ini bertujuan untuk melihat pendidikan ekonomi dalam keluarga yang dilakukan oleh orang tua kepada anak. Semua orang tua telah mengajarkan pendidikan ekonomi keluarga dengan cara yang berbeda. Pentingnya pendidikan ekonomi dalam keluarga adalah membentuk anak untuk menggunakan uang secara rasional. Adapun pendidikan ekonomi dalam keluarga yaitu keteladanan, kebiasaan, diskusi dan komunikasi, dan rasionalitas konsumsi. Peneliti menggunakan metode penelitian kualitatif dengan pendekatan fenomenologi. Teknik yang digunakan dalam penelitian ini adalah purposive sampling. Teknik data dilakukan dengan observasi, wawancara dan dokumentasi. Kesadaran orang tua untuk mengajarkan pendidikan ekonomi dalam keluarga cukup tinggi. Dengan melakukan pembelajaran yang intensif dan penuh motivasi dari orang tua, anak akan cepat memahami dan menerapkannya dalam kehidupan sehari-hari.
Pengaruh kualitas pelayanan biro akademik dan kemahasiswaan (BAK) terhadap kepuasan mahasiswa Universitas Trunojoyo Madura
Authors: Larastiyana Susanto Firsty , Siswanto Ely
Published: January 2022

Abstract

To find out the level of quality of service that has been given to consumers or their customers, student and community satisfaction as users of academic administration services waws used as an indicator. The student satisfaction surveys conducted in this study aims to know the level of Madura Trunojoyo University students’ satisfaction on the quality of academic administration services throughout the year 2021. This study used quantitative approach with survey method. The survey was carried out by making a closed questionnaire using Google form to investigate students’ satisfaction. The questionnaire were then distributed online to students who previously used academic administrative services of the academic bureau and the student council of the Madura Trunojoyo University in 2021. The obtained 100 respondents represented an entire population that used the academic administration services of the academic bureau and student affairs in 2021. Results obtained in this study suggest that the quality service variable, especially in Financial Administration Bureau, has a significant impact on the satisfaction of the student Trunojoyo Madura University.

Abstrak

Untuk mengetahui level kualitas servis yang diberikan kepada konsumen, kepuasan mahasiswa dan masyarakat, sebagai pengguna jasa administrasi akademik, digunakan sebagai sebuah indikator. Survei kepuasan mahasiswa pada penelitian ini bertujuan untuk menelusuri tingkat kepuasan mahasiswa di Universitas Trunojoyo Madura pada kualitas jasa administrasi akademik, selama 2021. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei. Survei dilakukan dengan menyebarkan kuesioner tertutup melalui Google Form untuk mengetahui tingkat kepuasan mahasiswa. Kuesioner tersebut kemudian didistribusikan secara daring kepada mahasiswa yang pernah menggunakan jasa layanan akademik dan dewan mahasiswa di Universitas Trunojoyo Madura pada 2021. Sebanyak 100 responden yang terkumpul mewakili seluruh populasi yang pernah menggunakan layanan biro akademik dan dewan mahasiswa pada 2021. Hasil dari penelitian ini menunjukkan bahwa variabel kualitas layanan, khususnya Biro Administrasi Keuangan, memiliki efek yang signifikan terhadap tingkat kepuasan mahasiswa Universitas trunojoyo Madura.