bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety climate and safety behaviors: Adapting and validating a positively worded safety climate scale through the time-lagged approach
Authors: Mirza Muhammad Zeeshan , Memon Mumtaz Ali , Javaid Muhammad Umair , Arshad Rameen
Published: September 2023

BACKGROUND: Contemporary literature raises serious questions about the inclusion of negatively worded items in the safety climate scale. Despite these reservations, limited efforts have been made to address this shortcoming. OBJECTIVE: The present study aims to adapt and empirically validate the ten-items group-level safety climate scale with the purpose of replacing negatively worded items with positively worded ones after a thorough validation process. The present study is one of the first to propose an empirically validated group-level safety climate scale that uses positive items to measure the safety climate construct. METHODS: Study 1 was conducted using a sample of 135 participants. Study 2 used a time-lagged approach to validate the scale, with a sample of 173 production workers from six oil and gas organizations in Malaysia. The Partial Least Squares Structural Equation Modeling (PLS-SEM) method was used to test the hypothesized relationships. RESULTS: In Study 1, the results of the exploratory factor analysis showed good reliability for the revised scale. In Study 2, the results of the PLS-SEM analysis demonstrated a positive relationship between safety climate and safety behaviors, thereby validating the revised and translated scale of safety climate. CONCLUSION: The revised safety climate scale will not only improve data quality, but it will also increase response rates. Additionally, the revised scale will assist managers in understanding the true perceptions of safety climate in their organization, regardless of the cultural context in which the scale is used.
DEVELOPMENT TRENDS AND ASSESSMENT OF CHANGES IN RECREATION WOODEN ARCHITECTURE OF THE CARPATHIAN REGION
Authors: Savchuk Andrii , Kaliberda Mykola
Published: September 2023

The article summarizes the experience of researching the architectural features of wooden recreation facilities in the Carpathian recreation region. Local and general trends in the development of recreational architecture are formulated. The negative and positive aspects of the development of the recreational industry within the Ukrainian Carpathian region are identified. The specific features of the architectural solutions of recreational facilities are formulated. When researching the genesis of architectural and planning decisions, it was discovered that this type of historical building, which was widespread in the region, was transformed into a public catering establishment. The development and complications of functional planning and volume solutions of modern cradles are shown on the example of specific samples. A comparative assessment of the changes and development of modern recreational architecture made of wood in the Carpathians was carried out. It was carried out on the basis of the periodization of the development of the Carpathian region already formed in the scientific literature. Features of recreational wooden architecture of each of the historical stages, including the modern period, are characterized.
PROBLEMS OF HUMANIZATION OF THE ENVIRONMENT IN MODERN CONDITIONS
Authors: Kiuntsli Romana , Besaha Iryna , Stepanyuk Andrii
Published: September 2023

Ukraine has taken significant steps towards integration into the European space during its period of independence. On February 21, 2019, the strategic course of Ukraine towards EU and NATO membership was defined in the Constitution of Ukraine, and as of June 23, 2022, Ukraine is a candidate for membership in the EU. The chosen course of entry into the European space requires changes and improvements in the economic, public, scientific space, and all areas of Ukrainian society. It is important to improve all components of the living environment, namely natural, production, housing, information and media environments, recreation, and daily commuting. At the same time, there is a problem of humanizing the living environment to provide equal conditions and opportunities for full living, work, and leisure for people with disabilities who have long been deprived of this opportunity.

The main tasks of the legal framework in the construction industry are to ensure the reliability and safety of construction objects and to establish requirements that ensure healthy and safe working, living, and domestic conditions for all segments of the population. These tasks have been declared in regulatory documents both during the Soviet period and in the period of Ukraine's independence. However, in practice, not all requirements for architectural and planning solutions for people with disabilities and people with limited mobility were fulfilled. The Ukrainian society's aspiration to integrate into the European space should forever leave behind such phenomena as legal nihilism, especially when it comes to complying with state norms and rules in construction.

A comprehensive approach is needed to create a fully inclusive living environment for all members of society, and simply making changes to building practices is not enough. It is necessary to make radical changes to Ukraine's transportation infrastructure, including retrofitting public transport and improving sanitary transport services to serve people with disabilities and other mobility-impaired groups in society. Creating comfortable conditions for people with disabilities, particularly those with hearing and visual impairments, requires changes in the information and media environment, including the creation of special training programs and visual and media information. It is also necessary to develop a state program for the rehabilitation and employment of war veterans with disabilities.
An Empirical Examination of Collateralization in Financial Markets
Authors: Lee David
Published: September 2023

This paper presents a new model for pricing financial instruments under different collateral arrangements. Moreover, we show that the model-implied price of a collateralized contract is very close to its market price, which suggests that the model is fairly accurate. Further, we find empirical evidence that asset prices in cleared markets are determined in a similar way to those in OTC markets. This practice is questionable, as the clearing process has changed the risk structure that affects outcomes. In fact, cleared derivatives are not economically equivalent to their OTC counterparts.
The Catholic School: Can The Centre Hold?
Authors: Carmody Brendan
Published: September 2023

The Catholic school today, when considered in a general sense, struggles to maintain its religious mission while its academic record remains commendable. This reflects a dualistic framework where the school’s science curriculum is preponderant. To regain an integrated perspective, it is argued that Catholic education needs to adopt a more satisfactory perspective on learning, which it is contended that the philosopher Bernard Lonergan developed. It is argued that Lonergan’s framework, with his notion of intellectual conversion, redeems the Catholic education, allowing it to be more satisfactorily inclusive of its scientific and confessional agendas.
Zeno and Einstein
Authors: Dace Ted
Published: September 2023

A common thread unites Zeno's denial of the reality of motion and Einstein's denial of an objective, i.e. frame-independent, present moment. Both claims privilege the intellect over experience, the abstract over the concrete. My guide – or rather foil – in this discussion is the philosopher of science Wesley Salmon.
Retroalimentación efectiva basada en inteligencia artificial generativa. Criterios de evaluación para la escritura de casos pedagógicos
Authors: Ossa Carlos , Willatt Carlos
Published: September 2023

En este documento de trabajo presentamos criterios preestablecidos para la evaluación con propósito de retroalimentación descriptiva de textos de respuesta a casos pedagógicos, producidos por estudiantes de la asignatura Ética Profesional Docente de la Facultad de Educación de la Universidad Autónoma de Chile. Para ello, hemos descrito tres criterios que permiten observar la calidad de tal escritura. El primero, Silueta de respuesta a un caso, verifica la presencia de partes o secciones que debe mínimamente poseer el texto. Del mismo modo, se describe la extensión mínima y máxima requerida para este propósito. Los otros dos criterios (Calidad de la propuesta de resolución del caso y Calidad de la comunicación escrita) son descriptivos, y su calidad está ponderada en las rúbricas que se proveen más abajo. La retroalimentación entregada a los estudiantes debe considerar las descripciones provistas en las rúbricas. Algunas de ellas pueden manifestar calidad de escritura de distinto tipo, por lo que pueden poseer características de dos niveles distintos, dependiendo de las dimensiones de cada criterio. Estas rúbricas constituyen el núcleo del prompt con el que se ha alimentado al sistema piloto llamado RECAP-GPT (retroalimentación de casos pedagógicos basada en Transformador Generativo Preentrenado). Este permite entregar feedback descriptivo automatizado e individual a las respuestas de casos pedagógicos escritas por estos estudiantes durante el semestre de primavera de 2023.
Efektivitas Katalis Zeolit Alam Ende pada Pirolisis Polietilena dari Sampah Plastik
Authors: Bani Gregorio Antonny
Published: September 2023

The high amount of plastic waste in landfills will pollute the environment. Direct combustion releases pollutants into the air, and recycling is only possible in small quantities. One method to overcome this problem is pyrolysis. However, pyrolysis requires a catalyst such as zeolite to accelerate the reaction rate, lower the activation energy, and improve the basic properties of the pyrolysis liquid. This study aims to characterize the activated natural zeolite Ende and determine the effect of the catalyst from the activated natural Ende zeolite on the activation energy, as well as the quality of the liquid resulting from the pyrolysis. Based on the research results, the activation process could change the degree of crystallinity became 36.63%, the surface area became 74.57 m2/g, the average radius became 20,21 Å, the pore volume became 72.34 cm3/g, and the number of acid sites became 4.342 NH3/g zeolite. Ende's active natural zeolite catalyst in the polyethylene pyrolysis process from plastic waste reduced the activation energy to 4,371.1 cal/mol in treating 0.10% catalyst composition from 1 kg of plastic. Increasing the temperature and catalyst improves the quality of pyrolysis oil, but the composition of the catalyst ratio is 0.10% of 1 kg of plastic.
Tourists’ Perceptions and Motivations for Local Food
Authors: Jibin Baby  , Joseph Arun George
Published: September 2023

Local foods play an influential role in improving the tourism experience in destinations. Local foods can enormously enrich the tourism experience by connecting tourists with the heart and soul of a destination. Past research has identified various perception and motivational factors that support local foods' purchase intentions, but only from a consumer point of view. As the demand for local foods in tourist destinations is gaining more and more importance year after year, this study investigates the influence of those perceptions and motivational factors on purchasing local foods in a tourism destination. A survey was conducted among 470 US tourists who have visited destinations and tasted or purchased local foods in the last three years. Regarding the perception of local foods, the study's findings show that factors like freshness, trust and transparency, preservatives free, and better nutrition are highly reported. Regarding the motivations to buy local foods, the study findings show that factors like supporting the local farmers, enhancing sustainable agriculture, increasing local revenue, and reducing carbon emissions were highly reported. The findings of this study will provide a holistic experience for the tourists that allows them to immerse themselves in the destination's food culture and support the local economy and community. By effectively developing and promoting the destination's local foods by highlighting and promoting the highly rated perception and motivational factors, the destination can attract more food enthusiasts and curious tourists seeking authentic food and cultural experiences.
APPLICATION OF ANALYTICAL TOOLS FOR EVALUATING THR PERFORMANCE OF A MANUFACTURING ENTERPRISE
Authors: Levandovska O.
Published: September 2023

The article focuses on the use of analytical tools, namely, methods of assessing the bankruptcy of an enterprise, developed by foreign authors. Calculations are made using various models, and it is proved that at the moment there is no "ideal" model that will take into account all the realities of the enterprise.
The current unstable situation of Ukraine's economy, namely the full-scale invasion of the aggressor country by the Russian Federation, creates additional difficulties for enterprises for development and normal functioning, so the issue of timely performance assessment and efficiency forecasting is particularly acute.
Analysis of recent research and publications. Today, there are many different publications on the topic of assessing the probability of bankruptcy, a significant number of authors are conducting various studies to identify the most reliable model for assessing the probability of bankruptcy from the models developed earlier by foreign scientists. And some experts studying this topic even offer their own methods. For example, the group of analysts O.Y. Bazilinska, T.G. Rzaeva, I.V. Stasiuk. Tereshchenko O.O. and others not only thoroughly analyzed the existing methods of assessing the probability of bankruptcy of an enterprise, but also presented a number of studies on the development of models for predicting the probability of bankruptcy in various sectors of the economy, such as construction, manufacturing and many others].Currently, a large number of different financial models have been developed that combine several different coefficients into one, resulting in a generalized assessment of the financial condition and determining the probability of bankruptcy. But the question arises, which method will really show the exact financial condition of the company and, moreover, give a forecast for the future? Therefore, the research topic is relevant.
The problems of applying methods for diagnosing bankruptcy of an enterprise at the early stages are currently characterized as the most pressing issues of our time.
The purpose of the article is to study the probability of bankruptcy of the manufacturing enterprise "X" on the basis of foreign forecasting methods.
Keywords: bankruptcy diagnostics, analytical support, analytical tool, bankruptcy assessment models.
Do Communities Have a Role in Community Archaeology in Jordan?
Authors: Ronza Maria Elena
Published: September 2023

Within the past 30 years, community archaeology worldwide has worked to address ethical concerns raised by the colonial nature of traditional archaeological missions, and over the past 20 years, Jordan has witnessed a transformation of this colonial enterprise in the rise of community archaeology as a discipline. Unfortunately, this transformation has occurred in the appearance but very often not in the substance. This chapter discusses how archaeology and colonialism are closely intertwined in Jordan, and how such a relationship is fuelled by a culture of welfarism that traps host communities in a vicious cycle brokered by non-governmental organisations that alienates them from their own heritage. The chapter aims to initiate a discussion around the role and voice of host community in archaeology and how community archaeology could contribute to transforming the status quo.
Safeguarding, Enhancing and Managing Archaeological Heritage and Museums in Iraq: The Contribution of the EDUU Project
Authors: Zaina Federico , Proserpio Licia , Scazzosi Giulia , Al-Lami Alaa Hussein Jasim , Al-Rubaie Riyam Hussein Abed
Published: September 2023

Over four decades of conflicts and instability have severely deteriorated Iraq’s social and political systems. These long-term trends have also progressively damaged the rich heritage of the country and repeatedly weakened its cultural infrastructures. Against this backdrop, in recent years, international institutions and funding bodies have promoted initiatives to revive and relaunch the Iraqi cultural heritage which is considered a critical component to support the wider post-conflicts recovery as well as an important player in the country’s post-oil reality. Among these, between 2016 and 2020, a European-Iraqi partnership launched the “EDUU - Education and Cultural Heritage Enhancement for Social Cohesion in Iraq” project, funded by the EuropeAid Programme of the European Union. The project focused on improving education and enhancing cultural heritage by connecting Iraqi universities, heritage institutions, secondary schools, museums and local communities. To this end, the EDUU project implemented a wide range of activities using archaeological, ethnoarchaeological, cultural heritage, and community engagement methodologies. This paper provides a critical analysis of the project results and lessons learned together with future outlooks to foster social cohesion through cultural heritage in the country.
Examining the Participation of Female Peacekeepers in the United Nations Peacekeeping Operations: The Contributions of Islamic Countries
Authors: Amaliyah Ridha Nahdhiyah Alma , Sallimi Hadidah , Surwandono Surwandono
Published: September 2023

The world of International Relations will never be separated from its history. Countries in the Middle East, especially Muslim-majority countries, still have a lot of conflicts going on. However, the contribution of Islam to the world of peace never stops. In the contemporary world, for example, this contribution is realized through the participation of Islamic countries in United Nations Peacekeeping Operations (UN PKO). This study aims to analyze the contributions of female peacekeepers of Islamic countries. This research uses the concept of peacekeeping and analyzes secondary data with the quality method and literature review approach as the data collection technique.  The result of this research shows that eight of 12 peace missions involved Muslim-majority countries such as Bangladesh, Pakistan, Egypt, and Indonesia, which sent the most female peacekeepers. This study found that the Muslim-majority countries have successfully implemented the UN PKO program, especially for the increasing number of female peacekeepers agenda. It also found that the female peacekeeper has a substantive and public function in the operations, such as their contribution to the operation in logistical, informational branches, and medical aid aspects. However, the UN PKO still emphasizes masculinity. This study shows that domestic issues including inadequate military personnel and social stigmatization of women's peacekeeping engagement greatly reduce women's representation in UN peacekeeping operations. This inherently impacts the Women, Peace, and Security agenda.
The Opportunity to Establish an Extradition Mechanism in the ASEAN
Authors: Miano Muhammad Ryan Ramadhani , Rachminawati Rachminawati
Published: September 2023

Extradition is transporting a suspect or defendant to the nation where the crime was committed to be prosecuted and punished. Under international law, states are not required to enter into extradition agreements. There are impediments to the implementation of extradition, such as disparities in sovereignty principles and perspectives on offenses; in addition, this impediment exists at the regional ASEAN level, such as terrorism that can be extradited based on the UN Convention, even without an agreement, recognizing its impact on sovereignty. Therefore, the conclusion of an extradition agreement is crucial. Using normative research methodologies and legal perspectives, this study will explore the prospects and challenges in forging extradition agreements at the ASEAN regional level and compare them to the E.U. processes. The study's results indicate that there is still enormous potential for forming an ASEAN extradition treaty, which has made substantial progress with the 2018 provisional draught. Regional barriers and limits comparable to those encountered by ASEAN are anticipated. Therefore, an extradition convention will assist law enforcement and contribute to regional collaboration. With an extradition agreement, perpetrators can be punished by the proper state, and victims or society can be restored to justice.
The Effectiveness of Cooperative Learning Model of Auditory, Intel-lectual, Repetition (AIR) Type Assisted by PowerPoint Media on Class VII Quadrilateral and Triangular Material in Kamus Yapirru Tebas Islamic Junior High School
Authors: Beti Nur Baiti Jannah , Rachmatika Fajriyah
Published: September 2023

This study describes the effectiveness of learning in the classroom using the auditory, intellectual, and repetition (AIR) cooperative learning model. This study also uses the help of PowerPoint media. This article's data presentation is part of a research report whose primary focus is observing the effectiveness of learning using the auditory, intellectual, repetition (AIR) cooperative learning model with the help of PowerPoint media. The research method uses descriptive qualitative to describe student learning outcomes, activities, and responses. Student learning outcomes are measured using learning outcomes tests and quiz question tests. Student activity data was carried out using student activity observation sheets. Student activity data was collected using student response questionnaire sheets. The subjects of this research were class VII students consisting of 24 students. Research results prove that: (1) Overall student learning outcomes meet the minimum completeness criteria (KKM), that is, all students score above the KKM. (2) Student activity is classified as active during learning. (3) Student responses are categorized as very good or positive
DAMPAK BROKEN HOME TERHADAP MOTIVASI BELAJAR PADA ANAK STUDI KASUS: O (INISIAL NAMA ANAK) MURID SD NEGERI 75 KOTA BENGKULU
Authors: Dani Barkah Yanuar Damar , Helmiyetti
Published: September 2023

Kuliah kerja nyata (KKN) adalah salah satu bentuk pendidikan dengan bentuk pengabdian kepada masyarakat dengan cara memberikan pengalaman belajar kepada mahasiswa untuk membaur di tengah – tengah masyarakat di luar kampus, dan secara langsung mengidentifikasi serta memberikan solusi masalah – masalah yang dihadapi. Broken home adalah suatu masalah di dalam rumah tangga yang berdampak buruk bagi anak. Anak dari keluarga yang broken home cenderung memiliki tersendiri untuk berbaur dengan yang lain. O merupakan anak dengan status keluarga broken home. Ayahnya wafat pada saat ia berumur sebelas tahun, ibunya sibuk mencari nafkah, kakaknya pergi merantau untuk membantu perekonomian keluarga. Setelah pulang sekolah O membantu pekerjaan rumah sebelum pergi ke lapak dagangan ibunya. Ibu O berprofesi sebagai pedagang buah di Simpang Kandis, ia berjualan dari pagi hingga larut malam sehingga tidak memiliki waktu untuk mendampingi belajar anaknya. O memiliki masalah susah menangkap pembelajaran pelajaran hal ini yan membuat motivasi belajarnya rendah. Pengumpulan data dilakukan sembari melakukan pendampingan terhadap anak dengan menggunakan teknik observasi, wawancara dan dokumentasi pribadi dengan teknis menyimak dan memperhatikan aktivitas anak, dan menulis semua kegiatan dan perilaku anak. Data yang terkumpul kemudian diolah dengan metode kualitatif dan dianalisis dengan analisa deskriptif. Anak dengan kasus broken home memiliki motivasi belajar tidak stabil dan cenderung rendah, maka dari itu sangat diperlukan peran orang tua dalam mendampingi kegiatan belajar anak. Kesehatan mental anak adalah hal penting, diharapkan kepada orang tua dapat menyeimbangkan kebutuhan fisik dan rohani anak. Orang tua merupakan panutan dan teladan bagi anak-anaknya. Pada proses pertumbuhan anak orang tualah yang berperan penting dalam pembuatan karakter terdekat anak. Pemberian motivasi dan penguatan karakter pada anak broken home dapat meningkatkan semangat untuk menggapai cita-citanya di masa depan.
SOSIALISASI PEMANFAATAN KOMPUTER DAN INTERNET UNTUK KEGIATAN BELAJAR PADA SISWA SD NEGERI 65 SELUMA SERTA PEMBUATAN WEBSITE DESA KAYU ARANG
Authors: Aprian Endi Taufik , Sari Julia Purnama
Published: September 2023

Kemajuan ilmu pengetahuan dan teknologi, khususnya teknologi informasi sangat pesat seperti komputer dan internet. Hal itu dikarenakan teknologi informasi menjadi ruang berkembang pesatnya peradaban dunia, begitu pula dengan dunia Pendidikan. Keberadaan teknologi dengan pemanfaatan komputer memiliki dampak yang baik maupun buruk bagi anak-anak. Perlu dilakukan kontrol dan pendampingan yang tepat untuk memastikan bahwa anak-anak menggunakan teknologi ini dengan bijak dan dalam batas yang sehat. Berdasarkan survey, Siswa Sekolah Dasar Negeri 65 Seluma belum memahami pemanfaatan komputer dan internet untuk kegiatan belajar. Oleh karena itu, diperlukan sosialisasi dengan pemberian pemahaman tentang Pemanfaatan Komputer dan Internet untuk kegiatan belajar serta dampak penggunaaannya agar siswa dapat menggunakan komputer dan internet dalam kegiatan belajar dengan benar. Selain itu, pada pengabdian ini juga dilakukan pembuatan website Desa Kayu Arang untuk membantu dalam menyebarkan informasi tentang desa Kayu Arang agar masyarakat desa atau luar dapat mengetahui informasi secara lengkap mengenai desa tersebut.

 

Kata Kunci: Teknologi, Komputer dan Internet, Sosialisasi, Website, Desa Kayu Arang
Carbon reduction performance and economic analysis in building construction - a pilot trial of low-carbon construction in the O•PARK2 construction phase
Authors: Zhang Yuhua , Li Xuejiao , Chan Chun Man , Li Yifan , Fan Ka Wai , Dai Ji , Shi Da
Published: September 2023

With the wide application of green building standards to reduce the carbon emissions from the operation phase, the carbon emissions during the construction phase are becoming more and more significant. Carbon footprint management is necessary and low-carbon measures, including low-carbon construction materials, construction site electrification, on-site renewable energy systems, and low-carbon alternative fuels should be considered. Taking a real case of a Design-Build-Operate project, O•PARK2, as a pilot trial, this study investigates the carbon reduction efficiency and cost increment of various low-carbon measures, and introduces the Green Premium Index to explore the tradeoff between carbon reduction and carbon offsetting by credit purchasing. Low-carbon measures adopted in O•PARK2 were proved to be carbon reduction efficient, achieving 4,612 tonnes of CO2e emission reduction. Early development of decarbonisation strategy enables further emission reduction and lower cost increments during the construction phase, in which low-carbon construction material should be prioritised, followed by construction site electrification, and the use of solar panels and B5 biodiesel. With low-carbon construction materials locally manufactured, construction decarbonisation progress in Hong Kong will be significantly enhanced. Lowcarbon construction should see carbon reduction as the main direction, and carbon offsetting as supplemental.
Perancangan Komik Historical Fiction Berbasis Cerita Bajak Laut Nusantara
Authors: Lesmana Moh. Eka , Zpalanzani Alvanov , Maslan Riama , Anasthasia D Erline
Published: September 2023

AbstrakPenggunaan historical fiction pada media populer seperti komik, film, game, dan lain-lain dengan pendekatan hiburan banyak menarik minat masyarakat untuk melihat berbagai fenomena sejarah. Penyampaian dengan pendekatan hiburan ini tentunya menjadi kekuatan dari genre historical fiction untuk dapat digunakan dalam mengangkat berbagai tema-tema sejarah Indonesia. Salah satu fenomena penting dalam sejarah maritim Indonesia yang tidak umum diketahui adalah fenomena ‘bajak laut’. Fenomena bajak laut yang marak di Indonesia pada masa kolonial merupakan bagian dari sejarah Nusantara yang penting karena pada dasarnya fenomena bajak laut di Nusantara tidak sepenuhnya merupakan gejala kriminal, namun juga merupakan bentuk perjuangan masyarakat maritim terhadap para penjajah pada masa lampau. Mengangkat tema ‘bajak laut’ melalui genre historical fiction dapat menjadi upaya untuk menyampaikan peristiwa sejarah maritim melalui pendekatan hiburan dan juga dapat membuka sudut pandang baru bagi masyarakat dalam melihat fenomena ‘bajak laut’ itu sendiri. Komik sebagai media hasil perancangan dipilih dengan melihat potensi media komik dan antusiasme pembaca komik di Indonesia yang sangat tinggi. Perancangan menggunakan metode design thinking and making dari Matt Cooke mulai dari tahap definition, divergent dan transformation menjadi tahapan yang digunakan dalam proses perancangan untuk menghasilkan karya desain yang terstruktur dan bisa menjangkau audiens dengan mudah dan luas. Kata Kunci: bajak laut, historical fiction, komik, Nusantara AbstractThe use of historical fiction in popular media such as comics, films, games, and others with an entertainment approach has attracted a lot of public interest in various historical phenomena. The presentation with entertainment approach is one of the potential of historical fiction genre and can be used in conveying Indonesian history. One of the most important phenomena in Indonesia's maritime history that is not commonly known is the story of 'piracy'. Piracy that flourished in Indonesia during the colonial period was an important part of maritime history because it was not entirely a criminal phenomenon, but was also a form of the battle against the colonialists. Bringing up the theme of 'piracy' through the historical fiction genre can be an effort to convey maritime historical events through an entertainment approach and can also open new perspectives for the public in seeing the phenomenon of 'piracy' itself. Comics were chosen by considering the potential of comics media and the high enthusiasm of comic readers in Indonesia, by using the Matt Cooke’s design thinking and making method from the definition, divergent and transformation it is hoped that the comics can become a medium that can reach an audience easily and widely. Keyword: comics, historical fiction, pirates
INVESTIGATION OF DRAINAGE IN URBAN AREA USING GEOGRAPHIC INFORMATION SYSTEM IN THE CASE OF NEKEMTE TOWN
Authors: Garoma Wayessa Shiferaw , Beyene Ayana Abera
Published: September 2023

Drainage is an important aspect of the urban, rural, forest, and agricultural environments as it aids in the removal of excess water volume. In Nekemte town, where this study is conducted, different drainage problems are encountered in different places. Most drainage structures built in this area were built without a thorough drainage investigation, causing a slew of issues for the people who lived there, particularly during the rainy season. The problems that increase the drainage problems from time to time in Nekemte town were caused by the illegal use of drainage structures (components) like pipes, culverts, and ditches, and their consequence is the overflow of water because of illegal waste (solid waste) in the drainage lines. The objective of this study was to investigate drainage problems using ArcGIS software in the case of Nekemte town. To achieve this objective, a digital elevation model of the area was created from contours. Different hydrological patterns were developed using the ArcGIS hydrology tool and combined with other tools to identify cross-drainage requirements. In the study area, there are ten (10) watersheds and an outlet (pour point). Three (3) stream orders exist in the study area. Protected areas are those that are at least fifty (50) meters from the stream network. The watershed, road (current and proposed), low drainage density, and stream order are all considered when calculating an area’s cross-drainage requirement. In the study zone, there are cross-drainage requirements in twenty (20) different places. Seventeen (17) of those cross-drainages lead to exits in the protected zone. The discharge of the area is also computed using the rational method. In general, this study found that cross drainage between Wollega and the stadium is inadequate and improperly placed.
Chronic application of alcohol-soluble gluten extract over undamaged skin causes clinical sensitization for life-threatening anaphylaxis via activation of systemic Th2 immune responses in mice
Authors: Jorgensen Rick , Gao Haoran , Chandra Shivam , Sundar Vaisheswini , Loy Jaden , Van Antwerp Chris , Ng Perry K. W. , Gangur Venu
Published: September 2023

Introduction

Gluten allergy is a major public health problem that is growing at an alarming rate. Specific mechanisms underlying sensitization to gluten remain incompletely understood. Currently, it is unclear whether chronic exposure to alcohol-soluble gluten extract via undamaged skin has the capacity to clinically sensitize mice for life-threatening anaphylaxis. Using an adjuvant-free mouse model, here we tested the hypothesis that chronic application of alcohol-soluble durum gluten (ASDG) extract will clinically sensitize mice for life-threatening anaphylaxis.

Methods

This study was conducted in a gluten-free Balb/c mouse colony that was established and maintained on a plant protein-free diet. Groups of adult female mice were exposed dermally to ASDG extract or vehicle once a week for 9-weeks. Specific (s) and total (t) IgE levels were quantified. Mice were challenged systemically with ASDG to measure symptoms of systemic anaphylaxis. Hypothermic shock response (HSR) and mucosal mast cell degranulation response (MMCR) were determined upon challenge. Spleen Th1, Th2, and other immune markers were quantified.

Results

We found that chronic exposure to ASDG elicited robust elevation of sIgE and tIgE. Systemic challenge with ASDG, but not vehicle, elicited life-threatening anaphylaxis associated with dramatic HSR and MMCR. Correlation analysis demonstrated direct positive inter-relationships among IgE, HSR, and MMCR. Anaphylaxis was associated with significant elevation of prototypic Th2 but not Th1 immune markers in the spleen.

Discussion/Conclusion

Our study collectively demonstrates that ASDG is intrinsically allergenic; and chronic exposure to ASDG via undamaged skin can clinically sensitize mice for life-threatening anaphylaxis via activating the systemic Th2 immune responses.
In situ photo-crosslinked hydrogel promotes oral mucosal wound healing through sustained delivery of ginsenoside Rg1
Authors: Xu Jie , Zhang Zhenghao , Ren Xiaofeng , Zhang Yunan , Zhou Yang , Lan Xiaorong , Guo Ling
Published: September 2023

Oral mucosal wounds exhibit an increased susceptibility to inflammation as a consequence of their direct exposure to a diverse range of microorganisms. This causes pain, slow healing, and other complications that interfere with patients’ daily activities like eating and speaking. Consequently, patients experience a significant decline in their overall quality of life. Therefore, the pursuit of novel treatment approaches is of great importance. In this study, ginsenoside Rg1, a natural active substance extracted from ginseng root, was chosen as a therapeutic agent. It was encapsulated in a screened photo-crosslinked hydrogel scaffold for the treatment of mucosal defects in the rat palate. The results demonstrated that Rg1-hydrogel possessed excellent physical and chemical properties, and that oral mucosa wounds treated with Rg1-hydrogel exhibited the greatest healing performance, as evidenced by more pronounced wound re-epithelialization, increased collagen deposition, and decreased inflammatory infiltration. Subsequent investigations in molecular biology confirmed that Rg1-hydrogel stimulated the secretion of repair-related factors and inhibited the secretion of inflammatory factors. This study demonstrated that the hydrogel containing ginsenoside Rg1 significantly promotes oral mucosal tissue healing in vivo. Based on the findings, it can be inferred that the Rg1-hydrogel has promising prospects for the therapeutic management of oral mucosal wounds.
Single cell and bulk transcriptome analysis identified oxidative stress response-related features of Hepatocellular Carcinoma
Authors: Zhang Shuqiao , Li Xinyu , Zheng Yilu , Liu Jiahui , Hu Hao , Zhang Shijun , Kuang Weihong
Published: September 2023

Background: Hepatocellular Carcinoma (HCC) is a common lethal digestive system tumor. The oxidative stress mechanism is crucial in the HCC genesis and progression.

Methods: Our study analyzed single-cell and bulk sequencing data to compare the microenvironment of non-tumor liver tissues and HCC tissues. Through these analyses, we aimed to investigate the effect of oxidative stress on cells in the HCC microenvironment and identify critical oxidative stress response-related genes that impact the survival of HCC patients.

Results: Our results showed increased oxidative stress in HCC tissue compared to non-tumor tissue. Immune cells in the HCC microenvironment exhibited higher oxidative detoxification capacity, and oxidative stress-induced cell death of dendritic cells was attenuated. HCC cells demonstrated enhanced communication with immune cells through the MIF pathway in a highly oxidative hepatoma microenvironment. Meanwhile, using machine learning and Cox regression screening, we identified PRDX1 as a predictor of early occurrence and prognosis in patients with HCC. The expression level of PRDX1 in HCC was related to dysregulated ribosome biogenesis and positively correlated with the expression of immunological checkpoints (PDCD1LG2, CTLA4, TIGIT, LAIR1). High PRDX1 expression in HCC patients correlated with better sensitivity to immunotherapy agents such as sorafenib, IGF-1R inhibitor, and JAK inhibitor.

Conclusion: In conclusion, our study unveiled variations in oxidative stress levels between non-tumor liver and HCC tissues. And we identified oxidative stress gene markers associated with hepatocarcinogenesis development, offering novel insights into the oxidative stress response mechanism in HCC.
The impact of FDI on ecological unequal exchange in China’s manufacturing industry
Authors: Gong Mengqi , Wang Longle , Li Xiaofan
Published: September 2023

This paper uses the panel data of manufacturing subdivision industry from 2000 to 2014 to calculate the exchange of ecological inequality through MRIO model. On this basis, the systematic GMM model is used to investigate the direct and indirect effects of Foreign Direct Investment on the unequal exchange of manufacturing ecology. In addition, the ecological unequal exchange in China’s manufacturing industry is decomposed into ecological unequal exchange on the production side, on the consumption side, with developed regions and with lessdeveloped regions. The study finds that: 1) Industry-wide research indicates that FDI inflows have a significant positive impact on reducing the unequal exchange in the manufacturing sector. This finding contributes to the existing literature on the effects of FDI on ecological inequality. 2) Path-specific studies reveal that FDI primarily reduces ecological inequality in the manufacturing sector through technological effects. However, the scale and structural effects of FDI exacerbate ecological inequality, confirming the findings of some scholars. This nuanced understanding of the effects of FDI on ecological inequality adds to the existing body of research. 3) From the perspective of FDI sources, FDI from Asian countries and regions is more beneficial for improving China’s ecological unequal exchange. This finding provides guidance for China’s FDI attraction policies. 4) Assessing pollution emissions inventories based on the principle of production responsibility is unfair to China from both the production and consumption perspectives. 5) From a regional perspective, FDI effectively reduces the impact of ecological unequal exchange in the manufacturing sector between China and developed economies. These findings confirm that China bears an unequal exchange in the trade process and enrich the understanding of the impact of FDI on ecological unequal exchange.
Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles
Authors: Aghara Hiral , Chadha Prashsti , Zala Devangi , Mandal Palash
Published: September 2023

Alcoholic liver disease (ALD) poses a significant threat to human health, with excessive alcohol intake disrupting the immunotolerant environment of the liver and initiating a cascade of pathological events. This progressive disease unfolds through fat deposition, proinflammatory cytokine upregulation, activation of hepatic stellate cells, and eventual development of end-stage liver disease, known as hepatocellular carcinoma (HCC). ALD is intricately intertwined with stress mechanisms such as oxidative stress mediated by reactive oxygen species, endoplasmic reticulum stress, and alcohol-induced gut dysbiosis, culminating in increased inflammation. While the initial stages of ALD can be reversible with diligent care and abstinence, further progression necessitates alternative treatment approaches. Herbal medicines have shown promise, albeit limited by their poor water solubility and subsequent lack of extensive exploration. Consequently, researchers have embarked on a quest to overcome these challenges by delving into the potential of nanoparticle-mediated therapy. Nanoparticle-based treatments are being explored for liver diseases that share similar mechanisms with alcoholic liver disease. It underscores the potential of these innovative approaches to counteract the complex pathogenesis of ALD, providing new avenues for therapeutic intervention. Nevertheless, further investigations are imperative to fully unravel the therapeutic potential and unlock the promise of nanoparticle-mediated therapy specifically tailored for ALD treatment.
A novel [89Zr]-anti-PD-1-PET-CT to assess response to PD-1/PD-L1 blockade in lung cancer
Authors: Puyalto Ander , Rodríguez-Remírez María , López Inés , Iribarren Fabiola , Simón Jon Ander , Ecay Marga , Collantes María , Vilalta-Lacarra Anna , Francisco-Cruz Alejandro , Solórzano Jose Luis , Sandiego Sergio , Peñuelas Iván , Calvo Alfonso , Ajona Daniel , Gil-Bazo Ignacio
Published: September 2023

Background

Harnessing the anti-tumor immune system response by targeting the program cell death protein (PD-1) and program cell death ligand protein (PD-L1) axis has been a major breakthrough in non-small cell lung cancer (NSCLC) therapy. Nonetheless, conventional imaging tools cannot accurately assess response in immunotherapy-treated patients. Using a lung cancer syngeneic mouse model responder to immunotherapy, we aimed to demonstrate that [89Zr]-anti-PD-1 immuno-PET is a safe and feasible imaging modality to assess the response to PD-1/PD-L1 blockade in NSCLC.

Materials and methods

A syngeneic mouse model responder to anti-PD-1 therapy was used. Tumor growth and response to PD-1 blockade were monitored by conventional 2-deoxy-2-[18F]fluoro-D-glucose ([18F]-FDG) PET scans. Additionally, tumor lymphocyte infiltration was analyzed by the use of an [89Zr]-labeled anti-PD-1 antibody and measured as 89Zr tumor uptake.

Results

Conventional [18F]-FDG-PET scans failed to detect the antitumor activity exerted by anti-PD-1 therapy. However, [89Zr]-anti-PD-1 uptake was substantially higher in mice that responded to PD-1 blockade. The analysis of tumor-infiltrating immune cell populations and interleukins demonstrated an increased anti-tumor effect elicited by activation of effector immune cells in PD-1-responder mice. Interestingly, a positive correlation between [89Zr]-anti-PD-1 uptake and the proportion of tumor-infiltrating lymphocytes (TILs) was found (Cor = 0.8; p = 0.001).

Conclusion

Our data may support the clinical implementation of immuno-PET as a promising novel imaging tool to predict and assess the response of PD-1/PD-L1 inhibitors in patients with NSCLC.
Evaluation and improvement of workplace vertical violence of nursing interns based on the Importance-Performance Analysis method
Authors: Xu Weifang , Feng Lili , Huang Haohao , Liu Siqi , Ye Mao , Tang Fuqin , Chuang Yen-Ching , Cai Fuman
Published: September 2023

Purpose

To analyze the key factors related to workplace vertical violence among nursing interns in China and to propose strategies to improve the nursing practice environment.

Methods

A cross-sectional study was conducted using the Importance-Performance Analysis (IPA) method to analyze the key factors and significance of workplace vertical violence for nursing interns. The data were obtained by administering a workplace vertical violence survey, designed specifically for this study, to 120 nursing interns at a tertiary general hospital in Zhejiang Province, China.

Results

The results demonstrated that the variables “I was ordered to do something beyond my ability and lacked guidance (C3),” “Errors in work have been repeatedly emphasized, spread, or exaggerated (C8),” “I was unjustly criticized (C9),” “I was withheld or blocked information purposefully (C1),” and “I was belittled at work (C2)” were the most crucial variables for determining the presence of workplace vertical violence of nursing interns. Moreover, they are priority improvement variables.

Conclusion

Managers must prioritize the use of relevant resources during internships to minimize false reinforcement and unfair criticism. Efforts should focus on improving information sharing, emphasizing the role of nursing interns in clinical work, providing better guidance when arranging for nursing interns to do work that exceeds their capacity, reducing workplace vertical violence, and improving nursing intern practice environments.
The Human Library and the development of cultural awareness and sensitivity in occupational therapy students: a mixed methods study
Authors: Pope Kirsty , Hewlin-Vita Heather , Chu Eli Mang Yee
Published: September 2023

Introduction

Monash university in Australia has adopted the Human Library as a teaching activity aimed at enhancing occupational therapy (OT) students’ cultural awareness and sensitivity; however, its effect on cultural competence in healthcare profession students has not been previously investigated.

Aim

To examine whether participation in a Human Library can facilitate the development of OT students’ cultural awareness and sensitivity and to understand the factors contributing to changes in cultural competence from the students’ perspective.

Method

This is a mixed-method study. Quantitative data was collected by participant characteristic survey and pre/post-Human Library cultural competence assessment (CCA). The quantitative data was used to inform the selection of participants and questions for the second qualitative phase. Quantitative data were analyzed using independent samples and paired t-tests, analysis of variance and Pearson correlation. Qualitative data were analyzed using coding reliability thematic analysis.

Results

Statistically significant increases were noted in CAS, CCB and overall CCA scores from pre- to post-Human Library. Participant characteristics such as gender, work experience in aged care and the health sector had a positive effect on pre-Human Library CCA results. Qualitative data demonstrated that participants perceived they had a level of cultural competence prior to attending the Human Library however, still made gains in cultural awareness and sensitivity and were motivated and inspired to provide culturally congruent healthcare.

Conclusion

The Human Library can be considered for inclusion within a suite of learning methods for healthcare professional student curricula as a cost-effective, flexible teaching method for the development of competencies for culturally congruent healthcare.