bluuebunny/crossref_metadata_2025 huggingface dataset:
Combining Action Observation Treatment with a Brain–Computer Interface System: Perspectives on Neurorehabilitation
Authors: Rossi Fabio , Savi Federica , Prestia Andrea , Mongardi Andrea , Demarchi Danilo , Buccino Giovanni
Published: December 2021

Action observation treatment (AOT) exploits a neurophysiological mechanism, matching an observed action on the neural substrates where that action is motorically represented. This mechanism is also known as mirror mechanism. In a typical AOT session, one can distinguish an observation phase and an execution phase. During the observation phase, the patient observes a daily action and soon after, during the execution phase, he/she is asked to perform the observed action at the best of his/her ability. Indeed, the execution phase may sometimes be difficult for those patients where motor impairment is severe. Although, in the current practice, the physiotherapist does not intervene on the quality of the execution phase, here, we propose a stimulation system based on neurophysiological parameters. This perspective article focuses on the possibility to combine AOT with a brain–computer interface system (BCI) that stimulates upper limb muscles, thus facilitating the execution of actions during a rehabilitation session. Combining a rehabilitation tool that is well-grounded in neurophysiology with a stimulation system, such as the one proposed, may improve the efficacy of AOT in the treatment of severe neurological patients, including stroke patients, Parkinson’s disease patients, and children with cerebral palsy.
Research Active Posterior Rhinomanometry Tomography Method for Nasal Breathing Determining Violations
Authors: Avrunin Oleg G. , Nosova Yana V. , Abdelhamid Ibrahim Younouss , Pavlov Sergii V. , Shushliapina Natalia O. , Bouhlal Natalia A. , Ormanbekova Ainur , Iskakova Aigul , Harasim Damian
Published: December 2021

This study analyzes the existing methods for studying nasal breathing. The aspects of verifying the results of rhinomanometric diagnostics according to the data of spiral computed tomography are considered, and the methodological features of dynamic posterior active rhinomanometry and the main indicators of respiration are also analyzed. The possibilities of testing respiratory olfactory disorders are considered, the analysis of errors in rhinomanometric measurements is carried out. In the conclusions, practical recommendations are given that have been developed for the design and operation of tools for functional diagnostics of nasal breathing disorders. It is advisable, according to the data of dynamic rhinomanometry, to assess the functioning of the nasal valve by the shape of the air flow rate signals during forced breathing and the structures of the soft palate by the residual nasopharyngeal pressure drop. It is imperative to take into account not only the maximum coefficient of aerodynamic nose drag, but also the values of the pressure drop and air flow rate in the area of transition to the turbulent quadratic flow regime. From the point of view of the physiology of the nasal response, it is necessary to look at the dynamic change to the current mode, given the hour of the forced response, so that it will ensure the maximum possible acidity in the legend. When planning functional rhinosurgical operations, it is necessary to apply the calculation method using computed tomography, which makes it possible to predict the functional result of surgery.
Multi-Layer Attack Graph Analysis in the 5G Edge Network Using a Dynamic Hexagonal Fuzzy Method
Authors: Kholidy Hisham A.
Published: December 2021

Overall, 5G networks are expected to become the backbone of many critical IT applications. With 5G, new tech advancements and innovation are expected; 5G currently operates on software-defined networking. This enables 5G to implement network slicing to meet the unique requirements of every application. As a result, 5G is more flexible and scalable than 4G LTE and previous generations. To avoid the growing risks of hacking, 5G cybersecurity needs some significant improvements. Some security concerns involve the network itself, while others focus on the devices connected to 5G. Both aspects present a risk to consumers, governments, and businesses alike. There is currently no real-time vulnerability assessment framework that specifically addresses 5G Edge networks, with regard to their real-time scalability and dynamic nature. This paper studies the vulnerability assessment in the 5G networks and develops an optimized dynamic method that integrates the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) with the hexagonal fuzzy numbers to accurately analyze the vulnerabilities in 5G networks. The proposed method considers both the vulnerability and 5G network dynamic factors such as latency and accessibility to find the potential attack graph paths where the attack might propagate in the network and quantifies the attack cost and security level of the network. We test and validate the proposed method using our 5G testbed and we compare the optimized method to the classical TOPSIS and the known vulnerability scanner tool, Nessus.
In Pursuit of Development: Post-Migration Stressors among Kenyan Female Migrants in Austria
Authors: Stuhlhofer Eunice Wangui
Published: December 2021

The emphasis on migration for development obscures its diverse challenges. The migration development nexus is paradoxical, problematic, and controversial. Remittances have long gained wide interest. Migrants’ subjective experiences are important in understanding overall migration outcomes. International African female migration has increased and it is underexplored. This paper investigates the psychosocial stressors of migration based on the lived experiences of Kenyan female migrants in Austria. A sample of 6 female migrants was selected. Narrative data were recorded and analysed using interpretative phenomenological analysis. The findings showed that migration resulted in troubled relationships within the core and extended families. The economic dependency of family members in Kenya caused conflicts in interracial marriages. Acculturation led to alienation, family separation and isolation. Achieving economic goals proved challenging due to unpredictable effects in Austria. Failed expectations driven by stereotypes about Europe resulted in disillusionment and high expenses. Routine racism and Black female body objectification affected the mental health of the participants. This article contributes to knowledge on international African migration and gender-specific issues concerning African female migrants. The results will inform policymakers, academia, future migrants and mental health providers. Further research on the effects of migration on African migrants is recommended.
Sun Protective Behaviors and Attitudes of Runners
Authors: Tenforde Adam S. , Fredericson Michael , Toth Kierann E. S. , Sainani Kristin L.
Published: December 2021

Sun exposure is a risk factor for skin cancer. Knowledge and behaviors around sun exposure protective measures are poorly described in athletes including runners. Our primary objective was to describe sun exposure behaviors and knowledge in a population of runners. A cross-sectional online survey was administered to 697 runners to measure the frequency of seven sun protective behaviors: sunscreen use on the face or body; wearing a hat, sunglasses, or long sleeves; running in shade; and avoidance of midday running. Between 54% and 84% of runners reported that they engaged in these behaviors at least sometimes, but only 7% to 45% reported frequent use. Of 525 runners who gave a primary reason for not using sunscreen regularly, 49.0% cited forgetfulness; 17.3% cited discomfort; and only a small percentage cited maintaining a tan (6.1%) or optimizing vitamin D (5.1%). Of 689 runners who responded to a question about what factor most influences their overall sun exposure habits, 39.2% cited fear of skin cancer, 28.7% cited comfort level, and 15.8% cited fear of skin aging. In addition to the seven individual behaviors, we also asked runners how frequently they took precautions to protect against the sun overall. We explored associations between participant characteristics and the overall use of sun protection using ordinal logistic regression. Overall, sun protection was used more frequently in runners who were female, older, or had a history of skin cancer. Runners appear to recognize the importance of sun protection and the potential consequences of not using it, but report forgetfulness and discomfort as the biggest barriers to consistent use. Interventions using habit-formation strategies and self-regulation training may prove to be most useful in closing this gap between knowledge and practice.
Forecast and Analysis of the Total Amount of Civil Buildings in China in the Future Based on Population Driven
Authors: Gong Tongdan , Zhang Wenjie , Liang Jinhan , Lin Changqing , Mao Kai
Published: December 2021

Controlling the scale of civil buildings is of great significance for energy saving and emission reduction in the construction field. This paper analyzes and extracts the key index parameters for the calculation of various civil building areas, establishes a detailed calculation model of the total civil building area, and constructs three different scenarios to predict various civil building areas in China from 2020 to 2060. Under the three scenarios, the total amount of civil buildings in China will reach a peak of 93.5, 84.6, and 76.3 billion m2 in 2040, 2035, and 2035, respectively. Under the constraints of energy consumption and carbon emission, this paper suggests that civil buildings develop according to the medium control scenario. In 2035, the urban per capita residential area will reach a peak of 42 m2, the urban residential area will reach 43 billion m2, the rural per capita residential area will reach the peak of 55 m2, the rural residential area will reach 20.6 billion m2, and the public building area will reach 21 billion m2. By 2060, the total area of civil buildings will drop to 76.5 billion m2, including 37.1 billion m2 of urban residential buildings, 18.5 billion m2 of rural residential buildings, and 20.9 billion m2 of public buildings.
The Role of Civil Society Sector in the Development of Art-Driven Regional Social Innovation: The Case of Benesse Art Site Naoshima and Art Setouchi
Authors: Aoo Ken
Published: December 2021

Recently art is increasing its presence as an “creative industry” to sustain local communities, by generating socio-economic values. Still, whether art can be a tool for social innovation to regenerate communities, especially in rural areas in aging societies, is an unanswered question. In this paper, we take the example of Benesse Art Site Naoshima and Art Setouchi in the island area of Western Japan, viewing how it transformed from a corporate-established museum to a regional initiative involving various stakeholders, including local residents and thus creating the process of dialogues and collaboration. By reconstructing the existing evidence with supplementary fieldwork and interviews and applying a tri-sectoral analysis of the processes, we present how the art sites developed to become a social innovation. We then illustrate the role of two key individuals, Soichiro Fukutake and Fram Kitagawa, and shed light on the different values and methodologies they brought into these art sites. We argue that such contributions from the civil society and philanthropy sector made a critical contribution to characterize BASN and Art Setouchi, in addition to the well-documented and recognized efforts from local government and business sectors. Finally, we propose that such values, methodologies, and persons who can embody and implement such values are crucial if other countries and areas are to replicate the model.
Fine-Granularity Urban Microclimate Monitoring Using Wearable Multi-Source Sensors
Authors: Ren Jinjing , Li Runfa , Jia Fengshuo , Yang Xinhao , Luo Yusheng , Wu Chenglin , Wang Wei , Yang Yuan
Published: December 2021

With the development of urbanization, the environment is the key to the safety of residents’ life and health and the United Nations’ Sustainable Development Goals (SDGs). Urban environmental changes and microclimate problems have attracted widespread attention. For the SDGs, monitoring the urban microclimate more accurately and effectively and ensuring residents’ environmental health and safety is particularly important when designing applications that can replace the traditional fixed-point urban environment or pollution monitoring. Based on the BeiDou Navigation Satellite System platform, this paper proposes a fine-granularity urban microclimate monitoring method using wearable multi-source (PM2.5, PM10, and other air pollutants) sensors innovatively, which includes the satellite position function by adopting the satellite pseudo-range differential positioning technology, environmental data perception through the embedded system and wireless transmission, as well as the GIS data processing and analysis system. The wearable sensor acquires position and service information data through the satellite positioning system and acquires environmental parameters through integrated mobile multi-source sensors. The data are cached and wirelessly transmitted to the cloud server for digital processing. The urban microclimate is evaluated and visualized through algorithm and map API. Mobile monitoring can be flexibly applied to complex and diverse urban spaces, effectively realizing all-weather, all-directional, and accurate microclimate monitoring of urban environmental quality.
Regression Models to Estimate Accumulation Capability of Six Metals by Two Macrophytes, Typha domingensis and Typha elephantina, Grown in an Arid Climate in the Mountainous Region of Taif, Saudi Arabia
Authors: Al-Sodany Yassin M. , Saleh Muneera A. , Arshad Muhammad , Abdel Khalik Kadry N. , Al-Bakre Dhafer A. , Eid Ebrahem M.
Published: December 2021

In this study, we explored the capacity for two promising macrophytes, Typha domingensis and Typha elephantina, to be used for the surveillance of contamination by six metals, i.e., Cu, Fe, Mn, Ni, Pb, and Zn, in the mountainous area of Taif City in Saudi Arabia. Regression models were generated in order to forecast the metal concentrations within the plants’ organs, i.e., the leaves, flowers, peduncles, rhizomes, and roots. The sediment mean values for pH and the six metals varied amongst the sampling locations for the respective macrophytes, indicating that similar life forms fail to indicate equivalent concentrations. For instance, dissimilar concentrations of the metals under investigation were observed within the organs of the two rooted macrophytes. The research demonstrated that the segregation of metals is a regular event in all the investigated species in which the metal concentrations vary amongst the different plant constituent types. In the current study, T. domingensis and T. elephantina varied in their capacity to absorb specific metals; the bioaccumulation of metals was greater within T. domingensis. The relationships between the observed and model-estimated metal levels, in combination with high R2 and modest mean averaged errors, offered an appraisal of the goodness of fit of most of the generated models. The t-tests revealed no variations between the observed and model-estimated concentrations of the six metals under investigation within the organs of the two macrophytes, which emphasised the precision of the models. These models offer the ability to perform hazard appraisals within ecosystems and to determine the reference criteria for sediment metal concentration. Lastly, T. domingensis and T. elephantina exhibit the potential for bioaccumulation for the alleviation of contamination from metals.
Urban Tourism Destination Image Perception Based on LDA Integrating Social Network and Emotion Analysis: The Example of Wuhan
Authors: Chen Xu , Li Jun , Han Wenxin , Liu Shudong
Published: December 2021

Tourism destination image perception aims to depict the urban tourism image from the perspective of the perception of tourists, which, therefore, sheds new light on the advancement and innovation of urban tourism. The model proposed in this study can effectively describe the image perception of a tourism destination, with its research conclusions providing a vital referential basis for the sustainable development of urban tourism. Combined with LDA, we construct the research framework of tourism destination image perception and then take the online comments of popular scenic spots in Wuhan on Ctrip Travel as an example. The results show that four aspects are included in tourists’ perception of the city image of Wuhan: experience, history culture, leisure service, and tourist destination. Among them, the social network of the experience dimension is most closely related. In addition, emotion analysis illustrates that tourists’ emotional tendencies tend to be positive under the four perceptual dimensions.
Plastic Pollution, Waste Management Issues, and Circular Economy Opportunities in Rural Communities
Authors: Mihai Florin-Constantin , Gündoğdu Sedat , Markley Laura A. , Olivelli Arianna , Khan Farhan R. , Gwinnett Claire , Gutberlet Jutta , Reyna-Bensusan Natalia , Llanquileo-Melgarejo Paula , Meidiana Christia , Elagroudy Sherien , Ishchenko Vitalii , Penney Simon , Lenkiewicz Zoe , Molinos-Senante Maria
Published: December 2021

Rural areas are exposed to severe environmental pollution issues fed by industrial and agricultural activities combined with poor waste and sanitation management practices, struggling to achieve the United Nations’ Sustainable Development Goals (SDGs) in line with Agenda 2030. Rural communities are examined through a “dual approach” as both contributors and receivers of plastic pollution leakage into the natural environment (through the air–water–soil–biota nexus). Despite the emerging trend of plastic pollution research, in this paper, we identify few studies investigating rural communities. Therefore, proxy analysis of peer-reviewed literature is required to outline the significant gaps related to plastic pollution and plastic waste management issues in rural regions. This work focuses on key stages such as (i) plastic pollution effects on rural communities, (ii) plastic pollution generated by rural communities, (iii) the development of a rural waste management sector in low- and middle-income countries in line with the SDGs, and (iv) circular economy opportunities to reduce plastic pollution in rural areas. We conclude that rural communities must be involved in both future plastic pollution and circular economy research to help decision makers reduce environmental and public health threats, and to catalyze circular initiatives in rural areas around the world, including less developed communities.
Evaluation and Influencing Factors of Agricultural Green Efficiency in Jianghuai Ecological Economic Zone
Authors: Li Genzhong , Tang Decai , Boamah Valentina , Pan Zhiwei
Published: December 2021

Traditionally, in the pursuit of economic development, ecological health was sacrificed, but this is no longer tenable considering the vast environmental damage that is difficult to control and expensive to repair. This is especially true for China’s Jianghuai River Basin (JRB). As a result, this paper uses the slacks-based measure (SBM) directional distance function and the tobit model on panel data from various cities and counties in the Jiangsu section of the HRB to empirically analyze regional green agricultural production efficiency and influencing factors from 2005 to 2019. The results illustrate that agricultural and environmental efficiency fluctuate upward in provincial areas. Still, a downward trend is observed in both redundancy and insufficiency rates of undesirable and desirable output. While this indicates improving regional agricultural and environmental efficiency, there is no readily detectable positive effect of technological progress and technical efficiency on green agricultural production efficiency improvements. Following a full analysis, policy implications are presented and discussed.
Acaulospora as the Dominant Arbuscular Mycorrhizal Fungi in Organic Lowland Rice Paddies Improves Phosphorus Availability in Soils
Authors: Nopphakat Khachonphong , Runsaeng Phanthipha , Klinnawee Lompong
Published: December 2021

Flooding in rainfed lowlands greatly impairs the mutualistic relationship between indigenous arbuscular mycorrhizal fungi (AMF) and rice. In flooded soils, root colonization by AMF is arrested, but some AMF genera, defined as the core AMF, remain present. However, the core AMF in rainfed lowlands and their symbiotic roles remain unknown. Here, we showed that Acaulospora fungi were the core AMF in rice seedling roots of the Sangyod Muang Phatthalung (SMP) landrace rice variety grown in non-flooded and flooded paddy soils. Subsequently, indigenous Acaulospora spores were propagated by trap cultures using maize as the host plants. Therefore, to clarify the roles of cultured Acaulospora spores in a symbiotic partnership, the model japonica rice variety Nipponbare was grown in sterile soil inoculated with Acaulospora spores, and recolonized with a native microbial filtrate from the organic rice paddy soil. Our data demonstrated that the inoculation of Acaulospora spores in well-drained soil under a nutrient-sufficient condition for six weeks enabled 70 percent of the rice roots to be colonized by the fungi, leading to higher phosphate (Pi) accumulation in the mycorrhizal roots. Unexpectedly, the growth of rice seedlings was significantly suppressed by inoculation while photosynthetic parameters such as fractions of incoming light energy and relative chlorophyll content were unaltered. In the soil, the Acaulospora fungi increased soil phosphorus (P) availability by enhancing the secretion of acid phosphatase in the mycorrhizal roots. The findings of this work elucidate the symbiotic roles of the dominant Acaulospora fungi from lowland rice paddies.
European Union Housing Policy—An Attempt to Synthesize the Actions Taken
Authors: Kucharska-Stasiak Ewa , Źróbek Sabina , Żelazowski Konrad
Published: December 2021

Adequate housing conditions are an indicator of a decent life, whereas the lack is one of the main reason behind so-called social exclusion. The importance of housing, in ensuring the social safety of citizens, as well as supporting social equity, has been emphasized for decades. Housing, however, also has an important economic dimension. A developed housing sector, in a broad sense guaranteeing the right to housing, is indicated as one of the main conditions for long-term economic growth. The significant role of housing, in deepening integrational processes on the old continent, has also been observed by the European Union. This article is a review and comprises of an attempt to synthesize arguments justifying the need to expand the European Union policy to include housing-related issues. For this purpose, a historical context of the perception of the role of housing in the process of European integration is presented; it characterizes the main phases of incorporating housing into EU policy, as well as indicating the most important areas and instruments of the European Union’s influence on the housing policy of member countries, along with an assessment of their results. The work makes use of the method of the critical analysis of literature, as well as an analysis of EU legal regulations, accounts, and reports referring to the housing sphere. Studies confirm the need for active involvement, aimed at including housing in the scope of EU competencies. The undertaken initiatives of a political, social, economic, environmental, and legal nature are the main forms of recommendations, propositions, and instruments supporting the implementation of common values. Studies conducted to date indicate that the implementation of a single EU housing policy for all member states is neither a simple nor desired task. A more effective solution would unquestionably be seeking out general solutions, addressed to groups of countries functioning under similar conditions. A European housing programme, which holds the status of European law supporting national housing policies, should be such a solution.
Efficiency of Governmental Policy and Programs to Stimulate the Use of Low-Emission and Electric Vehicles: The Case of Romania
Authors: Sechel Ioana C. , Mariasiu Florin
Published: December 2021

The contemporary demands for massive reductions in industrial pollution caused by the transport sector, especially in large urban agglomerations, compel local and national authorities to propose, develop, and implement programs and policies that have the ultimate goal of significantly reducing (or eliminating) pollution. The aim of this article is to provide a primary analysis of the effectiveness of Romanian government policies in terms of reducing pollution (CO2 emissions) caused by transportation (due to the “Rabla Plus” (RP) program, through which financial subsidies are granted for the purchase of a new plug-in hybrid electric vehicles (PHEVs) or battery electric vehicle (BEVs)). After analyzing the justification for the use of low-emission and electric vehicles in traffic (as a major solution to eliminate pollution), a comparative analysis of energy-efficient transport for Romania and Europe is presented in order to identify the directions in which it is necessary to develop and implement government policies specifically in Romania, considering a series of indicators chosen and considered by the authors to be important, including CO2 emissions compared with the size of the road infrastructure, the number of registered vehicles, the number of passengers transported, and the quantity of goods transported. With the identification of the ability of government programs to encourage the acquisition and use of low-emission and electric vehicles in traffic, the efficiency achieved is calculated in terms of the net CO2 emissions eliminated (average values of 1949.23 CO2 tons/year and 1.71 CO2 tons/vehicle). Furthermore, this aspect is also beneficial for analyses in terms of the economic costs involved (the associated costs are estimated to be 7034.17 EUR/ton of CO2 eliminated from the transportation sector), identifying new directions of action that are more cost-effective and sustainable and on which government policies should focus in the future.
Great Minds Think Alike, Fools Seldom Differ: An Empirical Analysis of Opportunity Assessment in Technology Entrepreneurs
Authors: Barry Patrick , Cormican Kathryn , Browne Sean
Published: December 2021

This study extends the literature on self-employment and entrepreneurship by offering empirical insights into the factors that influence technology entrepreneurs at the early stages of the new venture creation process. Specifically, this research focuses on how technology entrepreneurs assess opportunities at the start of the process. Using data from technology entrepreneurs in Ireland, we analyze differences between part-time entrepreneurs and full-time entrepreneurs and discover that not all entrepreneurs attach importance to activities that were previously considered fundamental. While we confirm that opportunity cost, market assessment, and financial analysis are critical and ever-present, we argue that aspiring technology entrepreneurs must be cognizant that when employment-related costs are included as a dimension of opportunity costs, the level and importance of opportunity costs rise for both part-time and full-time entrepreneurs. We also find that whether nascent entrepreneurs work full-time or part-time on the new venture has an impact on which activities are completed and at what point of the process they are completed. For example, we show that part-time entrepreneurs identify markets earlier than full-time entrepreneurs whereas the opposite is true when it comes to financial data preparation. We argue that a greater understanding of these issues will help technology entrepreneurs to make informed decisions. As a result, our findings may influence an aspiring entrepreneur’s decision to start a new venture. They also have ramifications for investors and support services. Consequently, we discuss theoretical contributions, practical ramifications, and future research possibilities.
Stability Characteristics and Mechanism of U-Shaped Metal Bellows under Symmetrical Cyclic Tension and Compression Process
Authors: Hao Zengliang , Yao Biao , Chen Yuhang , Luo Junting
Published: December 2021

The U-shaped metal bellows expansion joint compensates for the pipeline displacement by its own deformation. The compensation performance of the metal bellows in the initial stage of tension and compression deformation is unstable. In this paper, the symmetrical cyclic tension and compression (SCTC) process of metal bellows was simulated by ABAQUS software. Then, the SCTC process experiment of metal bellows was completed on the universal material testing machine. The distribution law of axial load with displacement and that of axial stiffness and yield load with cycles of metal bellows were obtained. Finally, the X-ray diffraction peak confirmed the deformation-induced martensite in the wave trough and proved that the plastic strain and hardness values of metal bellows increased with the displacement amplitude. The microstructure in the wave trough area was observed by a Zeiss microscope, and the stability characteristics mechanism of the metal bellows was revealed. The martensite in the wave trough increases the grain boundary area under SCTC loading. The forward movement of the slip band in the grain caused by large deformation reached an equilibrium state with the resistance at the grain boundary, which promotes the macroscopic mechanical properties of the metal bellows to be stable characteristics under SCTC loading.
Argumentation Schemes in Technology-Mediated Open Innovation Product-Service Models: An Activity Systems Perspective
Authors: Adamides Emmanuel D. , Karacapilidis Nikos I. , Konstantinopoulos Konstantinos
Published: December 2021

The paper uses activity theory for understanding and managing the complexity involved in the transition of a product-service organization from closed to the technology-mediated open mode of innovation. In particular, activity theory is used to facilitate the alignment of the open innovation model adopted with the organization’s dominant argumentation scheme by developing nested representations of the innovation process in the traditional closed mode, as well as in the user-led innovation and user co-creation modes, associated with product- and service-provision operations, respectively. For all cases, we concentrate on the argumentation-in-innovation activity and its context. We arrive at insights about the process of Activity Based Analysis (ABA) in this endeavor and the issues raised through action research in a product-service firm in the food and beverages sector, aiming at adopting an open innovation strategy implemented in the innovation community mode.
Effectiveness and Safety of Intradetrusor OnabotulinumtoxinA Injection for Neurogenic Detrusor Overactivity and Overactive Bladder Patients in Taiwan—A Phase IV Prospective, Interventional, Multiple-Center Study (Restore Study)
Authors: Wang Chung-Cheng , Chou Eric Chieh-Lung , Chuang Yao-Chi , Lin Chih-Chieh , Hsu Yu-Chao , Liao Chun-Hou , Kuo Hann-Chorng
Published: December 2021

We conducted a phase IV, pre/post multi-center study to evaluate the efficacy and safety of intradetrusor onabotulinumtoxinA injection in patients with neurogenic detrusor overactivity (NDO, n = 119) or overactive bladder (OAB, n = 215). Patients received either 200U (i.e., NDO) and 100U (i.e., OAB) of onabotulinumtoxinA injection into the bladder, respectively. The primary endpoint for all patients was the change in the PPBC questionnaire score at week 4 and week 12 post-treatment compared with baseline. The secondary endpoints were the changes in subjective measures (i.e., questionnaires: NBSS for patients with NDO and OABSS for those with OAB) at week 4 and week 12 post-treatment compared with baseline. Adverse events included symptomatic UTI, de novo AUR, gross hematuria and PVR > 350mL were recorded. The results showed that compared with baseline, PPBC (3.4 versus 2.4 and 2.1, p < 0.001) and NBSS (35.4 versus 20.4 and 18.1, p < 0.001) were significantly improved at 4 weeks and 12 weeks in NDO patients. In addition, compared with baseline, PPBC (3.5 versus 2.3 and 2.0, p < 0.001) and OABSS (9.1 versus 6.2 and 5.7, p < 0.001) were significantly improved at 4 weeks and 12 weeks in OAB patients. Eight (6.7%) had symptomatic UTI and 5 (4.2%) had de novo AUR in NDO patients. Twenty (9.3%) had symptomatic UTI but no de novo AUR in OAB patients. In conclusion, we found that intradetrusor onabotulinumtoxinA injections were safe and improved subjective measures related to NDO or OAB in our cohort.
Anabaenopeptins from Cyanobacteria in Freshwater Bodies of Greece
Authors: Zervou Sevasti-Kiriaki , Kaloudis Triantafyllos , Gkelis Spyros , Hiskia Anastasia , Mazur-Marzec Hanna
Published: December 2021

Cyanobacteria are photosynthetic microorganisms that are able to produce a large number of secondary metabolites. In freshwaters, under favorable conditions, they can rapidly multiply, forming blooms, and can release their toxic/bioactive metabolites in water. Among them, anabaenopeptins (APs) are a less studied class of cyclic bioactive cyanopeptides. The occurrence and structural variety of APs in cyanobacterial blooms and cultured strains from Greek freshwaters were investigated. Cyanobacterial extracts were analyzed with LC–qTRAP MS/MS using information-dependent acquisition in enhanced ion product mode in order to obtain the fragmentation mass spectra of APs. Thirteen APs were detected, and their possible structures were annotated based on the elucidation of fragmentation spectra, including three novel ones. APs were present in the majority of bloom samples (91%) collected from nine Greek lakes during different time periods. A large variety of APs was observed, with up to eight congeners co-occurring in the same sample. AP F (87%), Oscillamide Y (87%) and AP B (65%) were the most frequently detected congeners. Thirty cyanobacterial strain cultures were also analyzed. APs were only detected in one strain (Microcystis ichtyoblabe). The results contribute to a better understanding of APs produced by freshwater cyanobacteria and expand the range of structurally characterized APs.
The Dipolar Solar Minimum Corona
Authors: Telloni Daniele
Published: December 2021

The large-scale configuration of the UV solar corona at the minimum activity between solar cycles 22 and 23 is explored in this paper. Exploiting a large sample of spectroscopic observations acquired by the Ultraviolet Coronagraph Spectrometer aboard the Solar and Heliospheric Observatory in the two-year period of 1996–1997, this work provides the first-ever monochromatic O vi 1032 Å image of the extended corona, and the first-ever two-dimensional maps of the kinetic temperature of oxygen ions and the O vi1037/1032 Å doublet intensity ratio (a proxy for the outflow velocity of the oxygen component of the solar wind), statistically representative of solar minimum conditions. A clear dipolar magnetic structure, both equator- and axis-symmetric, is distinctly shown to shape the solar minimum corona, both in UV emission and in temperature and expansion rate. This statistical approach allows for robust establishment of the key role played by the magnetic field divergence in modulating the speed and temperature of the coronal flows, and identification of the coronal sources of the fast and slow solar wind.
Industry Interconnectedness and Regional Economic Growth in Germany
Authors: Shutters Shade T. , Seibert Holger , Alm Bastian , Waters Keith
Published: December 2021

Urban systems, and regions more generally, are the epicenters of many of today’s social issues. Yet they are also the global drivers of technological innovation, and thus it is critical that we understand their vulnerabilities and what makes them resilient to different types of shocks. We take regions to be systems composed of internal networks of interdependent components. As the connectedness of those networks increases, it allows information and resources to move more rapidly within a region. Yet, it also increases the speed and efficiency at which the effects of shocks cascade through the system. Here we analyzed regional networks of interdependent industries and how their structures relate to a region’s vulnerability to shocks. Methodologically, we utilized a metric of economic connectedness called tightness which quantifies a region’s internal connectedness relative to other regions. We calculated tightness for German regions during the Great Recession, comparing it to each region’s economic performance during the shock (2007–2009) and during recovery (2009–2011). We find that tightness is negatively correlated with changes in economic performance during the shock but positively during recovery. This suggests that regional economic planners face a tradeoff between being more productive or being more vulnerable to the next economic shock.
Population Variability Generated during Rescue Process and Passaging of Recombinant Mumps Viruses
Authors: Slović Anamarija , Košutić-Gulija Tanja , Forčić Dubravko , Šantak Maja , Jagušić Maja , Jurković Mirna , Pali Dorotea , Ivančić-Jelečki Jelena
Published: December 2021

Recombinant mumps viruses (MuVs) based on established vaccine strains represent attractive vector candidates as they have known track records for high efficacy and the viral genome does not integrate in the host cells. We developed a rescue system based on the consensus sequence of the L-Zagreb vaccine and generated seven different recombinant MuVs by (a) insertion of one or two additional transcription units (ATUs), (b) lengthening of a noncoding region to the extent that the longest noncoding region in MuV genome is created, or (c) replacement of original L-Zagreb sequences with sequences rich in CG and AT dinucleotides. All viruses were successfully rescued and faithfully matched sequences of input plasmids. In primary rescued stocks, low percentages of heterogeneous positions were found (maximum 0.12%) and substitutions were predominantly obtained in minor variants, with maximally four substitutions seen in consensus. ATUs did not accumulate more mutations than the natural MuV genes. Six substitutions characteristic for recombinant viruses generated in our system were defined, as they repetitively occurred during rescue processes. In subsequent passaging of primary rescue stocks in Vero cells, different inconsistencies within quasispecies structures were observed. In order to assure that unwanted mutations did not emerge and accumulate, sub-consensus variability should be closely monitored. As we show for Pro408Leu mutation in L gene and a stop codon in one of ATUs, positively selected variants can rise to frequencies over 85% in only few passages.
Microarray-Based Detection of Antibodies against SARS-CoV-2 Proteins, Common Respiratory Viruses and Type I Interferons
Authors: Savvateeva Elena , Filippova Marina , Valuev-Elliston Vladimir , Nuralieva Nurana , Yukina Marina , Troshina Ekaterina , Baklaushev Vladimir , Ivanov Alexander , Gryadunov Dmitry
Published: December 2021

A microarray-based assay to detect IgG and IgM antibodies against betacoronaviruses (SARS-CoV-2, SARS, MERS, OC43, and HKU1), other respiratory viruses and type I interferons (IFN-Is) was developed. This multiplex assay was applied to track antibody cross-reactivity due to previous contact with similar viruses and to identify antibodies against IFN-Is as the markers for severe COVID-19. In total, 278 serum samples from convalescent plasma donors, COVID-19 patients in the intensive care unit (ICU) and patients who recovered from mild/moderate COVID-19, vaccine recipients, prepandemic and pandemic patients with autoimmune endocrine disorders, and a heterogeneous prepandemic cohort including healthy individuals and chronically ill patients were analyzed. The anti-SARS-CoV-2 microarray results agreed well with the ELISA results. Regarding ICU patients, autoantibodies against IFN-Is were detected in 10.5% of samples, and 10.5% of samples were found to simultaneously contain IgM antibodies against more than two different viruses. Cross-reactivity between IgG against the SARS-CoV-2 nucleocapsid and IgG against the OC43 and HKU1 spike proteins was observed, resulting in positive signals for the SARS-CoV-2 nucleocapsid in prepandemic samples from patients with autoimmune endocrine disorders. The presence of IgG against the SARS-CoV-2 nucleocapsid in the absence of IgG against the SARS-CoV-2 spike RBD should be interpreted with caution.
RETRACTED: Expression of SARS-CoV-2 Spike Protein Receptor Binding Domain on Recombinant B. subtilis on Spore Surface: A Potential COVID-19 Oral Vaccine Candidate
Authors: Sung Johnny , Liu Ying , Wu Kam-Chau , Choi Man-Chung , Ma Chloe , Lin Jayman , He Emily , Leung David , Sze Eric , Hamied Yusuf , Lam Dominic , Kwong Keith
Published: December 2021

Various types of vaccines, such as mRNA, adenovirus, and inactivated virus by injection, have been developed to prevent SARS-CoV-2 infection. Although some of them have already been approved under the COVID-19 pandemic, various drawbacks, including severe side effects and the requirement for sub-zero temperature storage, may hinder their applications. Bacillus subtilis (B. subtilis) is generally recognized as a safe and endotoxin-free Gram-positive bacterium that has been extensively employed as a host for the expression of recombinant proteins. Its dormant spores are extraordinarily resistant to the harsh environment in the gastrointestinal tract. This feature makes it an ideal carrier for oral administration in resisting this acidic environment and for release in the intestine. In this study, an engineered B. subtilis spore expressing the SARS-CoV-2 spike protein receptor binding domain (sRBD) on the spore surface was developed. In a pilot test, no adverse health event was observed in either mice or healthy human volunteers after three oral courses of B. subtilis spores. Significant increases in neutralizing antibody against sRBD, in both mice and human volunteers, after oral administration were also found. These findings may enable the further clinical developments of B. subtilis spores as an oral vaccine candidate against COVID-19 in the future.
A Review of Equivalent Circuit Model Based Online State of Power Estimation for Lithium-Ion Batteries in Electric Vehicles
Authors: Guo Ruohan , Shen Weixiang
Published: December 2021

With rapid transportation electrification worldwide, lithium-ion batteries have gained much attention for energy storage in electric vehicles (EVs). State of power (SOP) is one of the key states of lithium-ion batteries for EVs to optimise power flow, thereby requiring accurate online estimation. Equivalent circuit model (ECM)-based methods are considered as the mainstream technique for online SOP estimation. They primarily vary in their basic principle, technical contribution, and validation approach, which have not been systematically reviewed. This paper provides an overview of the improvements on ECM-based online SOP estimation methods in the past decade. Firstly, online SOP estimation methods are briefed, in terms of different operation modes, and their main pros and cons are also analysed accordingly. Secondly, technical contributions are reviewed from three aspects: battery modelling, online parameters identification, and SOP estimation. Thirdly, SOP testing methods are discussed, according to their accuracy and efficiency. Finally, the challenges and outlooks are presented to inspire researchers in this field for further developments in the future.
Not All Disasters Are Created Equal: An Evaluation of Water Issues in Fire and Hurricane Media Coverage in the United States
Authors: Sanchez Danielle , Eagleston Holly , Anker Benjamin , Jenkins La Tonya , Gunda Thushara
Published: December 2021

Water resources are greatly impacted by natural disasters, but very little is known about how these issues are portrayed in the media across different types of disasters. Using a corpus of over 600 thousand local newspaper articles, this research evaluates whether the amount of coverage of water-related concerns of fires and hurricanes reflects news values associated with magnitude and proximity. A more detailed analysis focused on wildfires, which occur on undeveloped land and have the potential to spread rapidly, was also conducted to further evaluate spatial patterns in disaster-related water coverage. Our results indicate that the newspaper coverage patterns for water issues are not equally connected to magnitude and proximity values for fires and hurricanes. In our sample, coverage of water issues in relation to fires and wildfires consistently had an inverse relationship with overall event magnitudes, whereas the coverage of water issues in relation to hurricanes demonstrated a positive correlation. Although wildfires are more likely to be clustered in the western part of the country, there was a lack of positive correlations with wildfire magnitudes in this region. Possible influences for these patterns (e.g., limited impacts to humans and lack of shock-value) are discussed. Given the media’s role in facilitating disaster management and recovery, these nuances in coverage variations provide insight into opportunities for informing water security, which is especially important given the increasing frequency of natural disasters.
Remote Triggering of Damage Followed by Healing Recorded in Groundwater Pressure
Authors: Shalev Eyal , Lutzky Hallel , Kurzon Ittai , Lyakhovsky Vladimir
Published: December 2021

Water levels in three adjacent water wells in the Yarmouk Gorge area have all responded to the 2020 Elazığ Mw 6.8 teleseismic earthquake. Water levels in two aquifers exhibited reciprocal behavior: during the first eight days after the earthquake, water level decreased by 40 cm in the deeper highly confined aquifer, and increased by 90 cm in the shallower less confined aquifer. The recovery of the water levels in both aquifers continued for at least three months. We interpret these observations as reflecting the increase in damage along the fault at the Yarmouk Gorge. Ground shaking increased the damage and permeability of this fault, temporarily connecting the two aquifers, allowing flow from the deep aquifer to the shallow one. Model results showing decreased permeability suggest that the fault healed by one order of magnitude within three days. This is the first documentation of decrease in permeability in a fault zone within such short time scales.