bluuebunny/crossref_metadata_2025 huggingface dataset:
Low levels of soluble TWEAK, indicating on-going inflammation, were associated with depression in type 1 diabetes: a cross-sectional study
Authors: Melin Eva O. , Dereke Jonatan , Hillman Magnus
Published: December 2020

Background

Low levels of the soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) and depression are linked to cardiovascular disease. Galectin-3, inadequate glycemic control and low high-density lipoprotein (HDL)-cholesterol levels were previously linked to depression in these patients with type 1 diabetes mellitus (T1DM). The main aim was to explore whether sTWEAK was associated with depression. A secondary aim was to explore diabetes related variables associated with low sTWEAK.

Methods

Cross-sectional design. T1DM patients (n = 283, men 56%, age18–59 years) were consecutively recruited from one specialist diabetes clinic. Depression was defined as Hospital Anxiety and Depression Scale-Depression sub scale ≥8 points. Blood samples, anthropometrics and blood pressure were collected, supplemented with data from electronic health records. Enzyme linked immunosorbent assays were used to measure sTWEAK and galectin-3. Low sTWEAK was defined as < 7.2 ng/ml and high galectin-3 as ≥2.6 ng/ml. Multiple logistic regression analyses were performed, calibrated and validated for goodness of fit. We adjusted for age, sex, diabetes duration, galectin-3, metabolic variables, serum-creatinine, smoking, physical inactivity, medication, and cardiovascular complications.

Results

For 29 depressed versus 254 non-depressed patients the prevalence rates were for low sTWEAK: 93 and 68% (p = 0.003) and for high galectin-3: 34 and 13% (p = 0.005) respectively. HDL-cholesterol levels were lower for the depressed (p = 0.015). Patients with low sTWEAK versus high sTWEAK had lower usage of continuous subcutaneous insulin infusion (CSII) (6% versus 17%, p = 0.005).

Low sTWEAK (adjusted odds ratio (AOR) 9.0, p = 0.006), high galectin-3 (AOR 6.3, p = 0.001), HDL-cholesterol (per mmol/l) (AOR 0.1, p = 0.006), use of antidepressants (AOR 8.4, p < 0.001), and age (per year) (AOR 1.05, p = 0.027) were associated with depression.

CSII (AOR 0.3, p = 0.003) and depression (AOR 7.1, p = 0.009) were associated with low sTWEAK.

Conclusions

Lower levels of sTWEAK and HDL-cholesterol and higher levels of galectin-3 were independently associated with depression in T1DM. These factors might all contribute to the increased risk for cardiovascular disease and mortality previously demonstrated in patients with depression. CSII (inversely) and depression were independently associated with low sTWEAK levels.
Hemobilia after bile duct resection: perforation of pseudoaneurysm into intra-pancreatic remnant bile duct: a case report
Authors: Yoshida Kazuhiro , Umeda Yuzo , Iwamuro Masaya , Matsumoto Kazuyuki , Kato Hironari , Uka Mayu , Matsui Yusuke , Yoshida Ryuichi , Kuise Takashi , Yasui Kazuya , Takagi Kosei , Araki Hiroyuki , Yagi Takahito , Fujiwara Toshiyoshi
Published: December 2020

Background

Hemobilia occurs mainly due to iatrogenic factors such as impairment of the right hepatic or cystic artery, and/or common bile duct in hepatobiliary-pancreatic surgery. However, little or no cases with hemobilia from the intra-pancreatic remnant bile duct after bile duct resection (BDR) has been reported. Here, we report a case of massive hemobilia due to the perforation of psuedoaneurysm of the gastroduodenal artery (GDA) to the intra-pancreatic remnant bile duct after hepatectomy with BDR.

Case presentation

A 68-year-old male underwent extended right hepatectomy with BDR for gallbladder carcinoma. He presented with upper gastrointestinal bleeding 2 months after the initial surgery. Upper endoscopy identified a blood clot from the ampulla of Vater and simultaneous endoscopic balloon tamponade contributed to temporary hemostasis. Abdominal CT and angiography revealed a perforation of the psuedoaneurysm of the GDA to the intra-pancreatic remnant bile duct resulting in massive hemobilia. Subsequent selective embolization of the pseudoaneurysm with micro-coils could achieve complete hemostasis. He survived without any recurrence of cancer and bleeding.

Conclusion

Hemobilia could occur in a patient with BDR due to perforation of the pseudoaneurysm derived from the GDA to the intra-pancreatic remnant bile duct. Endoscopic balloon tamponade was useful for a temporal hemostasis and a subsequent radiologic interventional approach.
A meta-analysis of measurement properties of the Western Ontario Meniscal Evaluation Tool (WOMET)
Authors: Krott Nikolas Leon , Betsch Marcel , Wild Michael
Published: November 2020

Background

We provide a meta-analysis for clinicians and researchers regarding the psychometric properties of the WOMET as a patient-reported outcome measure (PROM) for patients with meniscal pathologies.

Methods

A comprehensive literature search identified 6 eligible papers evaluating WOMET measurement properties in patients with different meniscal injuries and meniscal treatments following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The quality of the included studies was evaluated using the four-point Consensus-based Standard for the selection of health Measurement Instruments (COSMIN) Checklist for good measurement properties. The checklist was specifically developed for studies on health-related PROMs.

Results

Our meta-analysis suggests that the WOMET can be used to evaluate patients with different meniscal injuries and meniscal treatments, especially acute or chronic meniscal injuries and traumatic or degenerative meniscal injuries treated operatively or conservatively. The WOMET shows satisfactory internal consistency, test-retest reliability, and construct validity. Due to limitations in both sample sizes and methodologies of the included studies, no conclusions can be drawn regarding the WOMET’s content validity, structure validity, cross-cultural validity, measurement error, or responsiveness. A further limitation of the studies included in this meta-analysis is the lack of cross-cultural validation, although recommended by the COSMIN Standards.

Conclusions

The first meta-analysis on measurement properties of the WOMET demonstrates satisfactory internal consistency, test-retest reliability, and construct validity. Further studies are needed, focusing on the methodological deficiencies highlighted in this meta-analysis. To ensure that the WOMET adequately reflects the symptoms, functions, and quality of life of patients with meniscal tears based on COSMIN criteria, it is necessary to assess the structural validity and content validity of this PROM.
Recent updates on Sintilimab in solid tumor immunotherapy
Authors: Liu Xuhong , Yi Yong
Published: December 2020

In recent years, there have been advancements in traditional patterns of tumor therapy with the adoption of immunotherapy. Its application with or without other combined regimens has attracted attention from clinicians. Sintilimab (Tyvyt®), a highly selective fully human IgG4 monoclonal antibody, blocks the binding site of programmed cell death protein 1 (PD-1), thereby, inhibiting the interaction between PD-1 and its ligands (PD-L1/2) to restore the endogenous anti-tumor T cell responses. Sintilimab has been proven to be clinically beneficial in multiple solid tumor therapies. Combination therapy and monotherapy have shown potential and encouraging anti-tumor efficacy with controllable and acceptable toxicities. The combination therapy is more likely to be a novel and promising therapeutic option. This study provides an overview of the status of sintilimab-based clinical trials in various solid tumors.
Application of one health approach in training at Makerere University: experiences from the one health workforce project in Uganda
Authors: Atusingwize Edwinah , Ndejjo Rawlance , Tumukunde Gloria , Buregyeya Esther , Nsamba Peninah , Tuhebwe Doreen , Kato Charles Drago , Naigaga Irene , Musoke David , Kabasa John David , Bazeyo William
Published: November 2020

The interconnections of humans, domestic animals, wildlife and the environment have increasingly become complex, requiring innovative and collaborative approaches (One Health approach) for addressing global health challenges. One Health is a multidisciplinary and multi-sectoral collaborative approach to human, animal, plant and environmental health. The role of academia in training professionals oriented in One Health is critical in building a global workforce capable of enhancing synergies of various sectors in improving health.

Makerere University, Uganda has implemented pre-service capacity building initiatives aimed to foster One Health competencies among students who are future practitioners. In addition to incorporating the One Health concept in didactic curricula, Student One Health Innovation Clubs, undergraduate field placements in 11 demonstration sites, graduate fellowships, small grants to support research and innovations, and cross-college collaborative training approaches have greatly aided the assimilation of One Health into the fabric of university offerings. Partnerships with government ministries, private sector and international agencies were initiated to benefit the students, as well as chart a path for experiential learning and in-service offerings in the future.

One major challenge, however, has been the tendency to focus on infectious diseases, especially zoonoses, with less consideration of other health issues. The opportunity for improvement, nonetheless, lies in the increasing emerging and re-emerging health concerns including epidemics, environmental pollution and related challenges which justify the need for countries and institutions to focus on building and strengthening multidisciplinary health systems.
Hot-carrier Separation Induced by the Electric Field of a p-n Junction between Titanium Dioxide and Nickel Oxide
Authors: Nakamura Keisuke , Oshikiri Tomoya , Ueno Kosei , Ohta Hiromichi , Misawa Hiroaki
Published: December 2020

We fabricated a p-type nickel oxide (NiO)/gold nanoparticle (Au-NP)/n-type titanium dioxide (TiO2) structure in which Au-NPs are placed in the p-n junction of TiO2 and NiO. The photoelectric properties of NiO/Au-NPs/TiO2 suggest that the main driving force of the hole separation from Au-NPs to NiO is the local electric field of the depletion layer of the p-n junction of TiO2 and NiO rather than the Schottky junction of Au and NiO.
Εισαγωγή στη Φιλοσοφία του Ελευθέρου Λογισμικού
Authors: Πέρρος Παναγιώτης
Published: November 2020

Δεν διατίθεται περίληψη
Η διάκριση μεταξύ φίλου και εχθρού στον Carl Schmitt
Authors: Γεωργακοπούλου Τρισεύγενη
Published: November 2020

Δεν διατίθεται περίληψη
La viticultura en Aranda de Duero: el comienzo de una crisis, 1580-1612. A propósito de una memoria de José de Medina Mercado.
Authors: Cuesta Nieto José Antonio
Published: December 2020

José de Medina Mercado, regidor de Aranda de Duero y poseedor de un vínculo y patronato, fue un importante cosechero, perteneciente a la élite política, social y económica de esta importante villa. Le atribuimos la autoría de una Memoria que contiene una serie casi continua de apuntes sobre el clima, las cosechas y los distintos precios a los que se vendía el vino. Esta información nos servirá para plantear de forma más precisa la evolución de la viticultura en la Ribera del Duero en un periodo en que se está produciendo el cambio de tendencia hacia la crisis del siglo XVII.
El catálogo de manuscritos del "Curioso andaluz": un misterio bibliográfico resuelto.
Authors: Eff-Darwich Peña Ángel Ignacio
Published: December 2020

El Catálogo de manuscritos especiales de España, anteriores al año 1600, que logró juntar en la mayor parte un curioso andaluz, es el largo título de una obra anónima y sin fecha, que se ha considerado tradicionalmente un inventario hecho en 1804 de una misteriosa biblioteca de la que nada se ha podido averiguar, aunque se cree que tras ese “curioso andaluz” se esconde el sevillano Argote de Molina. En las líneas que siguen, demostraremos que el Catálogo no pasa de ser un simple listado de títulos de manuscritos que su anónimo autor sacó de diversas fuentes escritas, algunas de las cuales damos a conocer.
Los rahales andalusíes del campo murciano y su trasvase a los nuevos propietarios cristianos (siglo XIII).
Authors: Martínez Martínez María
Published: December 2020

La reorganización administrativa del territorio (delimitación de
alfoces a las ciudades) y la reestructuración del secano murciano con el reparto de
los rahales andalusíes encontrados por los conquistadores castellanos proyectaron
la colonización del campo tras su integración en la Corona de Castilla a mediados
del siglo XIII; proyecto que no fue posible. El estudio se centra en comprender
a través del conocimiento histórico e historiográfico y de la toponimia-antroponimia la naturaleza económica y social de los rahales andalusíes como espacios
agrarios en poder de las élites aristocráticas y “burguesas” urbanas, así como su
localización cartografiada en sus correspondientes distritos catastrales, lo que facilita su ubicación aproximada. La comparativa colonizadora efectuada sobre el
campo andalusí y castellano permite, pese a las incertidumbres, obtener una serie
de posibilidades cualitativas y cuantitativas acerca del poblamiento y el aprovechamiento del vasto territorio de secano y, en concreto, de las propiedades privadas denominadas rahales que lo articulaban. Finalmente, el impacto que sobre el
territorio causó la efectiva soberanía castellana en la segunda mitad del siglo XIII
se traduciría a la postre en un nuevo paisaje cultural: tierras deshabitadas e incultas, de tránsito y estancia estacionales favorables al flujo y reflujo de la ganadería
ovina trashumante.
How to walk the talk
Authors: Caswell Jo
Published: December 2020

Jo Caswell provides advice on feeling confident about accompanying an Ofsted inspector on their ‘learning walk’ of the setting. Staff who have familiarised themselves with the Early Years Inspection Handbook will be in a strong position to communicate the strengths of their practice.
REVIEWS
Authors: Hewson Claire
Published: December 2020

These recommended reads focus on key debates – how children have the right to learn through active play and why ‘alternative narratives’ need to inform the teaching of our national history.
Value of experience
Authors: Lawson Deborah
Published: December 2020

The impact of the pandemic will have a long-term, negative impact on early years job opportunities and it is the 41 – 60 age-group who are most at risk of losing out.
Set them free
Authors: Rawstrone Annette
Published: December 2020

A child's right to play is so important that is it recognised in the United Nations Conventions on the Rights of the Child. Doing so outdoors is especially important – particularly in the current climate of constrained living.
Kirby's Rule of 20: the veterinary nurse's critical patient checklist part 4
Authors: Waxman Courtney
Published: November 2020

Kirby's Rule of 20 is a patient checklist including 20 parameters that should be checked daily in the critically ill patient. It reviews the established evidence-based information regarding patient checklist use in veterinary emergency and critical care medicine. The list of 20 will be discussed over a four-part series to give an appropriate level of information and attention to each patient parameter. Part 4 includes: wound healing, drug dosage and metabolism, pain control, nursing care, tender loving care.
Rehabilitation and recovery times for canine patients post hemilaminectomy
Authors: Vine Katherine
Published: November 2020

The recovery of ambulation is a crucial part of the recovery process for canine patients with intervertebral disc disease undergoing a hemilaminectomy. Although ambulation is accomplished in most cases, many are left with deficits in strength and coordination. Human medicine suggests that postoperative rehabilitation improves patient outcomes; it is therefore useful to examine whether the same would be true for canine patients. Additionally, as veterinary nurses it is important to understand why certain rehabilitative procedures are being performed for spinal patients, and whether those procedures actually help the patient to recover.
Effect of Förster resonance energy transfer efficiency and pump wavelength absorption on the acceptor’s amplified spontaneous emission in an on-chip droplet system
Authors: Aswathy S. , Soniya N. , Alee K. Shadak
Published: December 2020

We demonstrate efficient amplified spontaneous emission (ASE) of an acceptor from a sophisticated on-chip dynamic droplet Förster resonance energy transfer (FRET) system. The effect of changing the FRET efficiency and the pump wavelength absorption by the donor molecules is studied using two FRET pairs having dissimilar donors [Rhodamine 6G (R6G) and Rhodamine B (RB)] but a common acceptor [Nile blue (NB)], in microdroplets of different sizes and shapes ranging from spherical to squashed cylindrical. We show that the threshold of acceptor ASE depends on the extent of resonance of pump wavelength with the absorption maximum of the donor molecule, whereas this has no effect on the FRET efficiency, in agreement with the existing finding that FRET efficiency is independent of the excitation wavelength. We also demonstrate a tunability of 18 nm in the acceptor ASE by tweaking the size and shape of the generated droplets from spherical to squashed cylindrical. The reason for tunability is attributed to a change in the effective concentration of the dye molecules in different droplets.
Word learning from a tablet app: Toddlers perform better in a passive context
Authors: Ackermann Lena , Lo Chang Huan , Mani Nivedita , Mayor Julien
Published: December 2020

In recent years, the popularity of tablets has skyrocketed and there has been an explosive growth in apps designed for children. Howhever, many of these apps are released without tests for their effectiveness. This is worrying given that the factors influencing children’s learning from touchscreen devices need to be examined in detail. In particular, it has been suggested that children learn less from passive video viewing relative to equivalent live interaction, which would have implications for learning from such digital tools. However, this so-called video deficit may be reduced by allowing children greater influence over their learning environment. Across two touchscreen-based experiments, we examined whether 2- to 4-year-olds benefit from actively choosing what to learn more about in a digital word learning task. We designed a tablet study in which “active” participants were allowed to choose which objects they were taught the label of, while yoked “passive” participants were presented with the objects chosen by their active peers. We then examined recognition of the learned associations across different tasks. In Experiment 1, children in the passive condition outperformed those in the active condition (n = 130). While Experiment 2 replicated these findings in a new group of Malay-speaking children (n = 32), there were no differences in children’s learning or recognition of the novel word-object associations using a more implicit looking time measure. These results suggest that there may be performance costs associated with active tasks designed as in the current study, and at the very least, there may not always be systematic benefits associated with active learning in touchscreen-based word learning tasks. The current studies add to the evidence that educational apps need to be evaluated before release: While children might benefit from interactive apps under certain conditions, task design and requirements need to consider factors that may detract from successful performance.
Role of Scx+/Sox9+ cells as potential progenitor cells for postnatal supraspinatus enthesis formation and healing after injury in mice
Authors: Ideo Katsumasa , Tokunaga Takuya , Shukunami Chisa , Takimoto Aki , Yoshimoto Yuki , Yonemitsu Ryuji , Karasugi Tatsuki , Mizuta Hiroshi , Hiraki Yuji , Miyamoto Takeshi
Published: December 2020

A multipotent cell population co-expressing a basic-helix-loop-helix transcription factor scleraxis (Scx) and SRY-box 9 (Sox9) has been shown to contribute to the establishment of entheses (tendon attachment sites) during mouse embryonic development. The present study aimed to investigate the involvement of Scx+/Sox9+cells in the postnatal formation of fibrocartilaginous entheses and in the healing process after injury, usingScxGFPtransgenic mice. We demonstrate that Scx+/Sox9+cells are localized in layers at the insertion site during the postnatal formation of fibrocartilaginous entheses of supraspinatus tendon until postnatal 3 weeks. Further, these cells were rarely seen at postnatal 6 weeks, when mature fibrocartilaginous entheses were formed. Furthermore, we investigated the involvement of Scx+/Sox9+cells in the healing process after supraspinatus tendon enthesis injury, comparing the responses of 20- and 3-week-old mice. In the healing process of 20-week-old mice with disorganized fibrovascular tissue in response to injury, a small number of Scx+/Sox9+cells transiently appeared from 1 week after injury, but they were rarely seen at 4 weeks after injury. Meanwhile, in 3-week-old mice, a thin layer of fibrocartilaginous tissue with calcification was formed at healing enthesis at 4 weeks after injury. From 1 to 2 weeks after injury, more Scx+/Sox9+cells, widely distributed at the injured site, were seen compared with the 20-week-old mice. At 4 weeks after injury, these cells were located near the surface of the recreated fibrocartilaginous layer. This spatiotemporal localization pattern of Scx+/Sox9+cells at the injured enthesis in our 3-week-old mouse model was similar to that in postnatal fibrocartilaginous enthesis formation. These findings indicate that Scx+/Sox9+cells may have a role as entheseal progenitor-like cells during postnatal maturation of fibrocartilaginous entheses and healing after injury in a manner similar to that seen in embryonic development.
Design, production and immunomodulatory potency of a novel allergen bioparticle
Authors: Gomord Véronique , Stordeur Virginie , Fitchette Anne-Catherine , Fixman Elizabeth D. , Tropper Guy , Garnier Lorna , Desgagnes Réjean , Viel Sébastien , Couillard Julie , Beauverger Guillaume , Trepout Sylvain , Ward Brian J. , van Ree Ronald , Faye Loic , Vézina Louis-P
Published: December 2020

Allergen immunotherapy (AIT) is the only disease-modifying treatment with evidence for sustained efficacy. However, it is poorly developed compared to symptomatic drugs. The main reasons come from treatment duration implying monthly injections during 3 to 5 years or daily sublingual use, and the risk of allergic side-effects. To become a more attractive alternative to lifelong symptomatic drug use, improvements to AIT are needed. Among the most promising new immunotherapy strategies is the use of bioparticles for the presentation of target antigen to the immune system as they can elicit strong T cell and B cell immune responses. Virus-like particles (VLPs) are a specific class of bioparticles in which the structural and immunogenic constituents are from viral origin. However, VLPs are ill-suited for use in AIT as their antigenicity is linked to structure. Recently, synthetic biology has been used to produce artificial modular bioparticles, in which supramolecular assemblies are made of elements from heterogeneous biological sources promoting the design and use of in vivo-assembling enveloped bioparticles for viral and non-viral antigens presentation. We have used a coiled-coil hybrid assembly for the design of an enveloped bioparticle (eBP) that present trimers of the Der p 2 allergen at its surface, This bioparticle was produced as recombinant and in vivo assembled eBPs in plant. This allergen biotherapeutic was used to demonstrate i) the capacity of plants to produce synthetic supramolecular allergen bioparticles, and ii) the immunomodulatory potential of naturally-assembled allergen bioparticles. Our results show that allergens exposed on eBPs induced a very strong IgG response consisting predominantly of IgG2a in favor of the TH1 response. Finally, our results demonstrate that rDer p 2 present on the surface of BPs show a very limited potential to stimulate the basophil degranulation of patient allergic to this allergen which is predictive of a high safety potential.
Education for Democratic Intercultural Citizenship, Wiel Veugelers (2019)
Authors: Massey Simon
Published: December 2020

Review of: Education for Democratic Intercultural Citizenship, Wiel Veugelers (2019)

Leiden and Boston: Brill, 194 pp.,

ISBN 978-9-00441-194-4, €45.00/$54.00
The American spaceport and the power of cultural imaginaries
Authors: Nesbit Jeffrey S.
Published: December 2020

Cape Canaveral, the site of the American space programme launch complex located on the coast of Central Florida, has both a deep history in technological innovation and has been the place for architecturally imagining the new frontier of civilization. The range and trajectory of this new extraterrestrial frontier today resides within this once remote wilderness at the ends of architecture – both at the ends of a disciplinary formation and the physical site that enables the departure from Earth. Cultural imaginaries, collective forms created by culture, such as images relating to the assumed efficiencies of space exploration, construct a political desire for departing the Earth, yet rely heavily on architectural and infrastructural devices that are soon left abandoned on our terrestrial surface. This article moves from the geographic space of the late nineteenth century to the celebrated technological objects of NASA’s Apollo 11 programme for reaching the moon. By tracking the range, escape and return of the Apollo programmes’ constructed environment, the American spaceport reveals an invisible wilderness as an architectural aesthetic formed out of the cultural imagination in the early twenty-first century.
Music workshops as a pathway to community engagement for military veterans
Authors: Dhokai Niyati
Published: December 2020

For military veterans who are integrating into civilian community settings after military service, community engagement often involves the negotiation of post-injury needs, the consideration of new roles within the family and community social structures and the transition from military to civilian life. Community-based music programmes can provide opportunities to explore new social relationships with family, friends and community members and reinforce a sense of well-being as well as inform facilitators about the different learning and health needs, particularly those leading to social isolation, of veterans and their families that may affect adherence and retention during the workshop series. This article examines the impact of participating in community-based guitar workshops using ethnographic observation, surveys and interviews with veteran participants. Longitudinal ethnographic information offers valuable insight to plan long-term arts engagement as veterans and their families transition to new communities and continue to utilize the arts as a way to provide positive peer-to-peer support.
Community Radio’s Amplification of Communication for Social Change, Juliet Fox (2019)
Authors: Budarick John
Published: December 2020

Review of: Community Radio’s Amplification of Communication for Social Change, Juliet Fox (2019)

London: Palgrave Macmillan, 252 pp.,

ISBN 978-3-03017-315-9, h/bk, £47.23
Revolution in the Echo Chamber: Audio Drama’s Past, Present and Future, Leslie Grace McMurtry (2019)
Authors: Chignell Hugh
Published: December 2020

Review of: Revolution in the Echo Chamber: Audio Drama’s Past, Present and Future, Leslie Grace McMurtry (2019)

Bristol: Intellect, 294 pp.,

ISBN 978-1-78320-982-8, h/bk, £18.72
El Conquis: ¿Un reality demasiado vasco? Análisis de un formato transcultural
Authors: Iturbe tolosa Andoni , Del castillo aira Itxaso
Published: December 2020

Este trabajo de investigación se centra en el estudio de caso del reality El conquistador del fin del mundo, el espacio más exitoso de EiTB (grupo de radiotelevisión pública vasca) en los últimos quince años. La metodología ha consistido, por un lado, en el visionado completo de su última edición 2019 (uno de los más visto de su historia) y en las entrevistas semiestructuradas con sus creadores. El objetivo del artículo es analizar y explicar la singularidad del formato, por lo que se ha optado por herramientas metodológicas que combinan los estudios antropológicos y televisivos, dentro del ámbito de los Estudios Culturales. Así, se han identificado algunas categorías que explican su excepcionalidad: la importancia y la tensión entre “jokoa” y “jolasa”; la estructura del grupo; la estrategia de los “zorros” y los “leones” y la representación de los cuerpos. La confluencia de dichas características determina un programa eminentemente vasco y singular que encarna la forma en que los vascos se ven y se representan.
A Survey on Vulnerabilities and Performance Evaluation Criteria in Blockchain Technology
Authors: Srivastav Rishi Kumar , Agrawal Devendra , Shrivastava Anurag
Published: November 2020

The blockchain technology firstly presented by Haber and Stornetta in the year 1990, and first time blockchain technology used in Bitcoin by Satoshi Nakamoto in 2008. The blockchain technology is truly decentralized technology. In blockchain technology, every block has consisted three main parts that is data, hash block, and the previous hash block. Hash is controls the uniqueness of each block and it is unique for each block. Each block also contains the hash of the previous block; thus, the blocks are connected to each other. A blockchain can divided into three categories public blockchain, consortium blockchain and private blockchain. The proposed paper provided the comparative and analytical review on the blockchain consensus algorithms.
La actividad musical en Fuente Librilla. Recorrido histórico a través de los programas de fiestas
Authors: López Núñez Norberto
Published: November 2020

El presente estudio tiene por finalidad identificar y analizar desde el punto de vista histórico la actividad musical presente en Fuente Librilla en las últimas tres décadas (1989-2019) a través de los programas de fiestas. Los programas de fiestas son publicaciones editadas de forma amateur a través de los servicios de edición de una imprenta y que carecen de depósito legal e ISBN. Desde el punto de vista metodológico, se ha realizado un estudio cualitativo de corte documental. Los resultados revelan la presencia de más de 154 agrupaciones de diversa índole relacionadas con la música. Principalmente de grupos u orquestas musicales para amenizar la verbena popular y propiciar el baile.
Continuing Medical Education Questions: December 2020
Authors: Moawad Fouad J.
Published: December 2020

Article Title: The Role of Symptom Association Analysis in Gastroesophageal Reflux Testing
Continuing Medical Education Questions: December 2020
Authors: Henderson Phillip K.
Published: December 2020

Article Title: Integrating genomics into clinical practice in HCC: The challenges ahead
EROSIVIDADE DA CHUVA NA REGIÃO DO MÉDIO SOLIMÕES, AMAZONAS, BRASIL
Authors: Silva Neto João Cândido André , Aleixo Natacha Cintia Regina
Published: December 2020

O objetivo do presente trabalho foi analisar a erosividade da chuva na região do Médio Solimões no estado do Amazonas, Brasil, a partir uma série histórica de dados de 1992 a 2012, retirados de trinta e duas (32) estações meteorológicas distribuídas na região. O valor médio do índice de erosividade foi determinado conforme a proposta de Lombardi Neto e Moldenhauer (1992), implementado no software de geoprocessamento Quantum GIS (QGIS) 2.18. Os índices de erosividade mensal na região apresentaram uma sazonalidade em que predomina índices de erosividade superiores a 700 MJ mm ha-¹ h -¹ mês-¹, o que corresponde às classes Muito Alta e Alta, os índices foram observados entre os meses de dezembro e maio. Do mês de junho até o mês de setembro, observou-se a diminuição dos índices mensais de erosividade, predominando valores inferiores a 500 MJ mm ha-¹ h -¹ mês-¹. Nos meses de outubro e novembro, os índices de erosividade voltam a aumentar, caracterizando-se como uma transição entre período seco e chuvoso na região do Médio Solimões. Os índices de erosividade anual predominantes na região foram valores superiores a 7000 MJ mm ha-¹ h -¹ ano-¹, correspondendo às classes Muito Alta e Alta.
HACIA UNA EDUCACIÓN UNIVERSITARIA QUE CONTEMPLE LAS ECONOMÍAS ALTERNATIVAS
Authors: Zaar Miriam Hermi
Published: December 2020

En la última década los Planes de Estudios Universitarios se han estado derivando hacia una formación técnico/tecnológica, en los que se relegan las Ciencias Humanas y Sociales a un segundo plano. En esta coyuntura son muchas las voces que se han manifestado contrarias a este nuevo modelo universitario, en el que los conocimientos tecnológicos se anteponen a la formación integral del individuo, lo que está reduciendo su capacidad de analizar críticamente la complejidad de la sociedad actual. El objetivo de este texto es debatir la necesidad de repensar el actual modelo curricular de enseñanza universitaria, de modo que éste tenga en cuenta perspectivas sociales y económicas que han ganado relevancia en las últimas décadas. Para esto proponemos un replanteamiento de los Planes de Estudios universitarios, con la finalidad de que éstos pongan énfasis en la pluralidad de enfoques teóricos y metodológicos, en la institución de espacios de debates y de praxis que fomenten la formación de opiniones críticas hacia el actual paradigma de sociedad, y en la búsqueda de vías alternativas en las que se incluye un abanico de prácticas que caracterizan las Economías Alternativas.
FAZER ETNOGEOGRAFIA NA CIDADE: AS PRÁTICAS ESPACIAIS DAS REDES E MICROCULTURAS JUVENIS DA PERIFERIA EM TORNO DA FESTA DO FLUXO
Authors: Ramos Elvis
Published: December 2020

A festa do fluxo permite, com base na etnogeografia, revelar a força aglomerativa e autônoma da explosão de agenciamentos juvenis nas periferias urbanas. Saindo de bairros periféricos, estes jovens elaboram capital espacial para transpor as escalas na cidade e estabelecer circuitos e territorialidades. Ao mesmo tempo, criam dissidências sociais, territoriais e estéticas na cidade. Trata-se de uma festa juvenil inserida em um circuito de lazer paralelo, com suas formas próprias de sociabilidade, consumo e visibilidade social.
AGROECOLOGIA E REFORMA AGRÁRIA: UM ESTUDO SOBRE AS PRÁTICAS AGROECOLÓGICAS NO ASSENTAMENTO CELSO FURTADO, PARANÁ
Authors: Valeriano da Silva Jucélia , Finatto Roberto Antônio , Freitas Eduardo Márcio
Published: December 2020

A partir do ano 2000, articulada à luta pela terra, a Agroecologia se constituiu como uma importante pauta do Movimento dos Trabalhadores Rurais Sem Terra (MST). Entretanto, o desenvolvimento das práticas agroecológicas em áreas de reforma agrária enfrenta uma série de entraves para a consolidação da Agroecologia como a principal matriz produtiva nos acampamentos e nos assentamentos. Este artigo analisa o processo de (des)territorialização da Agroecologia no assentamento Celso Furtado, município de Quedas do Iguaçu, Paraná. A pesquisa teve cunho teórico e empírico, com tratamento qualitativo dos dados. Foram realizadas entrevistas com os agricultores de diferentes comunidades do assentamento, além de trabalhos de campo nas unidades de produção, a fim conhecer o histórico de implantação da Agroecologia no período do acampamento e caracterizar como as práticas agroecológicas estão sendo realizadas atualmente. Identificamos que o trabalho desenvolvido pelo MST, em conjunto com outras instituições, possibilitou a territorialização da Agroecologia nos acampamentos 10 de Maio e José Abílio dos Santos. Entretanto, por motivos diversos, após a formação do assentamento Celso Furtado ocorreu o processo de desterritorialização da Agroecologia. Atualmente, a prática agroecológica está reduzida a pequenas áreas, mas, ainda assim, sua presença se apresenta como resistência ao modelo de produção convencional.
O CÓDIGO CULTURAL DA LINGUAGEM COMO “MARCA” DA IDENTIDADE TERRITORIAL NO VALE DO TAQUARI/RS
Authors: Franz Juliana Cristina , Bezzi Meri Lourdes
Published: December 2020

O presente artigo objetiva entender os processos contraditórios e combinados, a manutenção e, simultaneamente, as transformações de características do código cultural da linguagem dos imigrantes e descendentes alemães que se instalaram historicamente e se reproduzem atualmente no Vale do Taquari/RS. A operacionalização da pesquisa, ocorreu primeiramente a partir de uma revisão teórica e histórica do processo de imigração e colonização alemã no Vale do Taquari/RS para posteriormente realizar a pesquisa empírica que visou, através de entrevistas, construir o conhecimento em torno da problemática central da pesquisa. Na região de estudo identificou-se uma expressividade no uso dos dialetos alemães no cotidiano, principalmente nos ambientes familiares, sendo mais presente na relação com as pessoas idosas e nas áreas rurais. Essa presença se restringe à língua falada, uma vez que não foi identificado domínio, por parte da comunidade, da escrita em alemão. A transmissão de significados da cultura ocorre com o uso da linguagem, principalmente da oralidade, pois o saber-fazer é transmitido entre as gerações por intermédio dela. A língua, além de ser um veículo de aproximação entre seus pares, também se configura como um elemento diferenciador, configurando-se como uma fronteira linguística, diferenciando o pertencimento a um grupo ou não.
The Role of Gene Therapy in the Treatments of Type 1 Diabetes Mellitus: a review
Authors: Smail Harem Othman
Published: November 2020

The main aims of this review were to understand the roles of gene therapy in the treatment and prevention of type 1 diabetes mellitus and I will discuss a brief history, approaches, vector types with the future of diabetes following clinical use. Type 1 diabetes mellitus is a metabolic condition that is identified by insufficient insulin development due to pancreatic damage to beta cells. Control, long life, and diagnosis of these metabolic disorders have become vital sources for many scientists and researchers. After 2000, the latest approaches to molecular medicine were introduced as one of the possible therapeutic options for diabetes type 1 diagnosis. Many genes have been reported as a clinical trial so that damaged genes can be treated and three main approaches shown about 50 years ago are islet transplantation, β cell regeneration, and insulin gene therapy to cure and prevent diabetes type. Treating diabetes through gene therapy can promise children and adolescents, but more clinical applications are needed to recognize it as a permanent route.
Evaluación de un algoritmo para selección de oportunidades espectrales en redes inalámbricas cognitivas
Authors: Rodríguez García Jorge Alexis , Mosquera Palacios Darin Jairo , Hernández Suárez Cesar Augusto
Published: December 2020

Las redes de radio cognitiva son una alternativa para mitigar la saturación del espectro radioeléctrico en algunas bandas de frecuencia, ello a través de una asignación espectral dinámica donde el usuario secundario aprovecha de forma oportunista los canales de frecuencia libres de la banda licenciada del usuario primario. En el presente artículo, se desarrolla un algoritmo para seleccionar los canales de frecuencia libres u oportunidades espectrales en una red de radio cognitiva basado en el método de colonia de abejas artificiales. La evaluación del algoritmo propuesto se realiza a través de simulaciones que incorporan el comportamiento real del usuario primario, se utilizan trazas de ocupación espectral reales obtenidas a través de la monitorización del espectro con la técnica de detección de energía; se tienen como criterios de evaluación el tiempo de ejecución y el número de handoffs fallidos. Los resultados evidencian una reducción del 62% en los tiempos de ejecución y del 36% en el número de handoffs fallidos al pasar de una población de colonia de abejas de 50 a 450.
Cartografía social y ambiental como mecanismo de participación campesina
Authors: Silva Velandia Barbara Camila
Published: November 2020

Al hablar de participación campesina y los mecanismos que aportan a su consolidación en el ámbito rural, se realiza una reflexión crítica por medio de la experiencia de cartografía social en el municipio que a su vez es Zona de Reserva Campesina en Cabrera, Cundinamarca, en la vereda Pueblo Viejo en 2017. La identificación comunitaria de zonas de interés ambiental y conflictos ambientales principalmente en áreas del Río y Páramo de Sumapaz del municipio aporta a la búsqueda de alternativas locales de resolución, proyección ambiental territorial. El ejercicio contribuye en la consolidación del reconocimiento político de campesinos y campesinas dadas las carencias históricas a nivel jurídico, reflejado en situaciones de violencia sistemática, pobreza, pérdida de identidad cultural y tradicional campesina en Colombia. Los aportes teóricos que sustentaron el planteamiento de los talleres, así como el análisis de resultados, permitieron evidenciar la importancia de la inclusión de la cartografía social dentro de los mecanismos recurrentes de participación campesina para la toma de decisiones que hagan parte del ordenamiento ambiental territorial del país.
Non-Verbal Communication In Anime "Diamond No Ace" Episodes 1 And 2 (Barthes Semiotics Approach)
Authors: Tresnasari Ningrum
Published: December 2020

Non-verbal communication is a communication process where the media used to communicate are body movements or gestures as a form of the depiction of emotions and feelings. Non-verbal communication consists of several types, but in this study, it only focuses on kinesic markers like body movements such as facial expressions, eye contact, hand movements and others. This study aims to describe the types and meanings contained in kinesic attributes in the anime "Diamond no Ace". The research data used are images from anime footage "Diamond no Ace" episode 1 and 2. The research method used is the Barthes semiotic approach. The types of kinesic markers in facial signs include eyes, eyebrows, forehead, cheeks, mouth and teeth, while gestures include hand movements and body postures from head to toe and iconography. Besides, the meaning contained in kinesic markers is divided into the denotative meaning and connotative meaning.
The Negotiation of Zainichi Identity and Resistance to Japanese Domination in Kazuki Kaneshiro Literary Text
Authors: Rahwati Wawat , Mulyadi Budi , Purwadi Feri
Published: December 2020

This study discusses the identity negotiation and resistance of the Zainichi minority to Japanese domination as the majority group in the literary text by Kazuki Kaneshiro. Zainichi is Korean people who came and have settled in Japan before and during World War II. As a minority group in Japan, Zainichi often faces discrimination from Japanese people due to his identity. Issues regarding the issue of Zainichi's identity are a dominant theme raised in the literary work of Zainchi (Zainichi bungaku). One of the authors of Zainichi's literary works is Kazuki Kaneshiro who wrote a novel entitled Go in 2007. Go novel as a literary text of Zainichi will be used as research data to reveal how Zainichi's identity negotiations are articulated by Zainichi characters and how their resistance against Japanese domination as the majority community group. By using postcolonial studies and analyses the structure of the narrative text, this research can reveal the forms of identity negotiation and resistances dis-course represented by Zainichi characters. Identity negotiation is seen through using Japanese name by Zainichi characters while interacting with the Japanese and changing the nationality from Korean to Japanese. Meanwhile, physical violence, mimicry (imitation), a mockery of Japanese behaviours, and maintaining their identity and Korean culture as resistances to counter the Japanese domination in the novel Go.
Pengaruh Beban Hidrolik pada Biofilter Anaerobik untuk Mengolah Air Limbah Rumah Potong Ayam dengan Menggunakan Persamaan Eckenfelder
Authors: Al Kholif Muhammad , Sugito Sugito
Published: December 2020

Industri Rumah Potong Ayam (RPA) bergerak dalam fungsi pemotongan ayam hidup dan mengolah menjadi karkas yang siap konsumsi. Industri RPA menghasilkan limbah baik dalam proses itu sendiri serta dalam mencuci peralatan dan fasilitas, hal ini ditandai dengan tingginya konsentrasi zat organik dan padatan tersuspensi. Tujuan penelitian ini adalah mengkaji pengaruh beban hidrolik pada biofilter anaerobik dengan menggunakan persamaan Eckenfelder berdasarkan variasi konsentrasi air limbah. Metode yang digunakan dalam penelitian ini adalah metode eksperimen yang dilakukan dalam skala laboratorium. Variasi beban hidrolik yang digunakan yaitu 0,0015 m3/m2.hari, 0,0022 m3/m2.hari, dan 0,0035 m3/m2.hari. Media yang digunakan sebagai tempat tumbuh dan berkembangbiaknya mikroorganisme adalah media bio ball dan media koral. Penerapan teknologi pengolahan air limbah dengan sistem anaerobik meiliki keunggulan tersendiri bila dibandingkan dengan pengolahan air limbah secara aerobik. Penggunaan nilai konstanta 0,5 diperoleh nilai tertinggi sebesar 1,90 yang terjadi pada reaktor 3 (R3) pada media bio ball dan 0,99 pada media koral. Hal ini menunjukan bahwa penerapan persamaan Eckenfelder pada sistem anaerobik lebih baik dari sistem aerobik. Biofilter anaerobik memberikan efisiensi yang sama pada beban hidrolik yang rendah yaitu sebesar 0,0015 m3/m2.hari. Rata-rata efisiensi penyisihan beban pencemaran BOD5 dan COD mencapai 96 % pada reaktor 1 (R1).
Pengaruh Kadar Protein Pakan yang Berbeda Berbasis Rasio E/P 8,5 Kkal/G Protein Terhadap Tingkat Konsumsi Pakan dan Pertumbuhan Udang Jerbung (Fenneropenaeus merguiensis)
Authors: Hertanti Tyas , Subandiyono Subandiyono , Hastuti Sri
Published: December 2020

Udang Jerbung (Fenneropenaeus merguiensis) membutuhkan protein sebesar 36-45%. Kebutuhan gross energy (GE) dan digestibility energy (DE) yaitu, 350-450 kkal 100g-1 dan 250-350 kkal 100g-1, sedangkan rasio E/P sebesar 7,98-9,56 kkal/g protein. Namun, informasi mengenai komposisi nutrisi pakan terutama keseimbangan antara protein, energi, dan E/P yang tepat untuk pertumbuhan udang jerbung masih sangat terbatas. Oleh sebab itu, perlu dilakukan penelitian mengenai pengaruh kadar protein pakan yang berbeda berbasis rasio E/P 8,5 kkal/g protein terhadap tingkat konsumsi pakan dan pertumbuhan udang jerbung (F. merguiensis). Penelitian ini bertujuan untuk mengkaji pengaruh kadar protein pakan yang berbeda berbasis rasio E/P 8,5 kkal/g protein terhadap tingkat konsumsi pakan (TKP), efesiensi pemanfaatan pakan (EPP), kecernaan protein, rasio efesiensi protein (REP), laju pertumbuhan relatif (RGR), dan kelulushidupan (SR) udang jerbung (F. merguiensis). Penelitian dilaksanakan pada bulan Februari-April 2019 di Balai Besar Perikanan Budidaya Air Payau (BBPBAP) Jepara, Jawa Tengah. Udang uji yang digunakan, memiliki bobot individu rata-rata 0,54±0,02 g/ekor. Udang uji dipelihara selama 40 hari dengan kepadatan 150 ekor/m2 dalam kontainer plastik dengan dimensi (p x l) sebesar (0,4 x 0,25) m2. Udang uji diberi pakan setiap hari sebanyak tiga kali secara fix feeding rate. Metode penelitian ini, yaitu rancangan acak lengkap (RAL) dengan 3 perlakuan dan masing-masing 6 pengulangan. Tiga perlakuan tersebut meliputi A (30%), B (35%), dan C (40%). Masing-masing dengan rasio E/P 8,5 kkal/g protein. Data yang diamati meliputi TKP, EPP, kecernaan protein, REP, RGR, SR, biomassa udang jerbung dan data penunjang yaitu kualitas air. Hasil penelitian menunjukkan bahwa nilai tertinggi dari TKP diperoleh pada perlakuan A, yaitu 82,31±0,56 g, sedangkan nilai tertinggi dari EPP, kecernaan protein, REP, RGR, SR, dan biomassa diperoleh pada perlakuan C, yaitu 17,09±0,82%, 98,02%, 0,55±0,03%, 3,91±0,29%, 88,89±5,44%, dan 20,93±0,61 g. Nilai kualitas air pada media pemeliharaan dalam kisaran yang optimal untuk kehidupan udang uji. Kesimpulannya, kadar protein pakan yang berbeda berbasis rasio E/P 8,5 kkal/g protein berpengaruh nyata (P0,05) terhadap SR. Pakan terbaik diperoleh pada perlakuan C, dimana menghasilkan performa petumbuhan yang tebaik.