bluuebunny/crossref_metadata_2025 huggingface dataset:
Compassionate Veterinary Care Platform
Authors: Tenis A. Aldo
Published: May 2024

Abstract: This paper proposes a digital appointment booking system for pet clinics, aimed at enhancing convenience and efficiency. Through the system's user-friendly interface, pet owners can easily schedule appointments for their beloved friends. Users can choose desired time slots, see which veterinarians are available, and indicate if they are there for an emergency consultation, vaccine, or routine check-up. The system also makes it possible for clinic employees to effectively manage appointments, which lowers wait times and improves efficiency.
A Study on Work-Life Balance of Employees in the Digital Age
Authors: N Prathiba
Published: May 2024

Abstract: In the digital age, when cutting-edge technologies have completely changed the nature of employment, this study investigates the complex dynamics of work-life balance. The study investigates how employees' capacity to strike a balance between their personal and work obligations is affected by technological breakthroughs. Key elements such as flexible hours, technology for communication, working from home, and employee well-being are examined in this study using a mix of surveys, interviews, and data analysis. The study highlights the value of company policies, boundary-setting, and communications in reducing possible risks to workers' well-being. Examined include long-term effects on professional development, job satisfaction, and retention. In the end, the research offers complete policy suggestions for companies and greater harmony between work and life in the digital age, taking into account the changing needs
Assessing the Effectiveness of Wellness Measures on Employee Engagement
Authors: R J Sujith
Published: May 2024

Abstract: Employee engagement is a crucial factor for organizations seeking to improve productivity, reduce turnover, and promote a positive work culture. In recent years, organizations have increasingly turned to wellness measures as a way to enhance employee engagement and overall well-being in the workplace. This study aims to assess the effectiveness of wellness measures on employee engagement by examining various strategies implemented by organizations and their impact on employee engagement levels. Wellness measures encompass a wide range of programs and initiatives designed to promote employee health, well-being, and work-life balance.
Machine Learning Exploration of Bank Marketing Data with Apache Spark
Authors: Naidu Dr. K. Purushotam
Published: May 2024

Abstract: Banks use the advanced analytics provided by Apache Spark to improve customer service and optimize marketing. By integrating machine learning, insights into consumer behavior can be gained through predictive modeling and efficient data processing. The main topics of this study are customer segmentation, predictive modeling and personalized marketing. PySpark's user-friendly interface and Spark's scalability support tactics related to growth, customer acquisition, and retention.
Assessing the Efficiency of Municipal Infrastructure - Case study in Vaaniyambadi Municipality, Tamilnadu, India
Authors: S Raghul
Published: May 2024

Abstract: This document discusses the evaluation of infrastructure facilities in Vaniyambadi, with the aim of improving the quality of life by addressing the issues and suggesting ways to enhance these facilities. The study focuses on physical infrastructure, including water supply, sewage and drainage, solid waste management, and electricity supply. It highlights the need for alternate water sources, additional pumping stations, and proper distribution of overhead water tanks to ensure equal access to water. It also emphasizes the importance of covering open drains, installing sewage treatment plants, and raising awareness about proper waste management to create a cleaner and healthier environment. Furthermore, the document addresses social infrastructure, particularly healthcare facilities and educational institutions. It suggests improvements such as increasing the number of beds and water supply in government hospitals, enhancing security systems in schools, and promoting collaboration between the community and municipal workers to maintain cleanliness. The document concludes by emphasizing the significance of infrastructure in driving economic and social development and the need for continuous improvement and modernization. Keywords: Municipal infrastructure, Physical infrastructure, Social infrastructure, Solid waste management , water supply
Experimental Investigations of Bituminous Concrete Using Dissimilar Trash Which Improve the Results
Authors: Bhat Ishfaq Ahmad , Chahal Ravi
Published: May 2024

Abstract: Bituminous mixture is an admixture of coarse aggregate, fine aggregate and fill. CRMB is based on a unique technology that permits homogeneity. CRMB is suited for use in heavy load traffic lanes, air fields. In this study, Crumb Rubber Modified Bitumen (CRMB-60) blended with normal asphalt binder VG-30 with various different percentages of crumb rubber in different proportions with constant optimum binder content i.e. 5% which shows improved characteristics when compared with regular bitumen. The cost for Bituminous course for CRMB-60 came out to be Rs 68.23 Lacs per Km which was 20.81% economical than the bituminous work done by normal VG- 30 bitumen. The Marshall Mix design using CRMB 55 with 0.04 % Zycosoil chemical, reflects the significant rise in stability, unit weight and flow values for better compaction and enhancing the workability conditions.
Parenting Style as Correlates of Anxiety Among Young Adults
Authors: Jain Dhwani , Sharma Dr Monu Lal
Published: May 2024

Abstract: This study recognizes the crucial role early familial experiences have in influencing mental health outcomes and examines the association between parenting methods and anxiety levels among young adults. In this exploratory study, a broad sample of young adults (ages 18 to 25) completed self-report questionnaires to gauge their anxiety levels and describe their parents' parenting approaches in retrospect. Incorporating Baumrind's authoritative, authoritarian, permissive, and neglectful parenting styles, the study used a comprehensive framework. The results showed a strong relationship between different parenting philosophies and young people' anxiety levels. Interestingly, those who grew up in authoritative households demonstrated reduced anxiety, underscoring the benefits of equitable parental response and engagement. On the other hand, those with histories of authoritarian or negligent parenting showed higher levels of anxiety, highlighting the possible drawbacks of excessively strict or uncaring parenting styles. In order to better understand the intricate interactions between parenting practices and anxiety consequences, the study also looked into potential mediating factors, such as attachment types and perceived social support. The findings of this study add to a more complex knowledge of the long-term effects of early experiences providing care on the mental health of young adults and could guide the development of focused therapies to lessen anxiety-related problems in this population. In the end, this study emphasizes how critical it is to take a multifaceted approach to studying the complex relationships between parenting practices and anxiety during the transition to adulthood.
Designing IDS to Analyze Malicious Attacks using Machine Learning
Authors: Dawkhar Prof. S. L. , Borate Nikita , Bangad Nandini , Patil Prashant , Joshi Sudeep
Published: May 2024

Abstract: This study presents a novel approach to enhance network security through the design and implementation of an Intrusion Detection System (IDS) employing machine learning (ML) techniques. The primary aim is to address current challenges in real-time threat detection by seamlessly integrating ML models, including Logistic Regression, Random Forest, and XGBoost. The research tackles drawbacks in existing systems, emphasizing the struggle with real-time threat detection, the complexity of ML integration. The working model classifies incoming requests as normal or intrusions, categorizing the latter into DDoS, R2L, U2R, or Probing attacks. Leveraging insights from four referenced papers, this study builds on efficient activation functions, optimized feature selection, and empirical analyses of ML models for adaptive network intrusion detection. Results showcase promising comparisons between ML algorithms which include Logistic Regression, Random Forest, XG Boost
PROCEDIMIENTO PARA DETERMINAR EL CONSENSO EN LA TOMA DE DECISIONES
Authors: Blanco Zamora Yankiel , Blanco Zamora Yaniris
Published: May 2024

Este artículo propone un procedimiento para arribar a un consenso cuando un grupo de expertos tiene preferencias relativamente homogéneas, sobre indicadores de importancia de los criterios “pesos” que evalúan las alternativas aplicadas; y es posible estimar el comportamiento o los resultados después de implementar cada alternativa. Estos “pesos” están relacionados con la posición de cada criterio en un ranking de importancia; por tanto, cuando se halla el consenso, éste puede interpretarse como el ranking consensuado por el grupo. La novedad en este procedimiento radica en que asume que el consenso puede no existir (el grupo puede no tener preferencias relativamente homogéneas); analizando simultáneamente el nivel de consistencia de cada uno de los “expertos” para que el procedimiento no fuerce el consenso. El procedimiento propuesto es presentado en un caso de estudio donde se utilizó la simulación para conocer los posibles resultados de implementar cada alternativa; lo que permitió evaluar matemáticamente las alternativas y romper con la forma clásica de evaluar las alternativas directamente por los expertos; y como resultado se logró mejorar la calidad del servicio de atención al cliente.
SESGOS COGNITIVOS Y DESEMPEÑO LABORAL: ASPECTOS RACIONALES Y NO RACIONALES
Authors: Pérez M Jesús R , Ibañez de Castillo Neyda
Published: May 2024

El objetivo de la presente investigación es identificar cualitativa y cuantitativamente los sesgos cognitivos importantes para el desempeño laboral de las pequeñas y medianas industrias del municipio Valencia, del Estado Carabobo, Venezuela, con la finalidad de poder resolver y dar indicios de cuáles son los elementos que dichas empresas deben tomar en cuenta, para redefinir, alcanzar y buscar mejores resultados, representativos de un buen desempeño laboral, en sus aspectos racionales y no racionales. Metodológicamente, la investigación se ajusta al paradigma positivista cuantitativo; siendo un estudio exploratorio, de campo y descriptivo, ajustado al método deductivo, usando la observación directa y un cuestionario; procesando los datos con la estadística descriptiva, para una evidencia empírica. Los resultados han arrojado que los expertos seleccionaron 15 elementos, agrupados en 4 sesgos cognitivos: ilusión de control (sesgo clave), aversión a las pérdidas, percepción selectiva, y exceso de confianza. Se concluye que los sesgos cognitivos en orden de importancia, para el desempeño laboral de las PyMEs abordadas y su mejor productividad son: aversión las pérdidas, exceso de confianza y exceso de ilusión de control, considerando a estos sesgos en los aspectos no racionales.
La mediación lúdico-pedagógica usada como herramienta de apropiación social de conocimiento. Resultado del proyecto de investigación Capaz de la Universidad Católica de Pereira
Authors: Betancurth Becerra Carlos Mario , Linares Andrés Felipe
Published: May 2024

La apropiación social del conocimiento es una herramienta que viene adquiriendo mayor relevancia en el campo de la investigación, debido a la necesidad de divulgación, comunicación y adquisición integral de los saberes producidos por la investigación hacia las comunidades. En el ámbito de la investigación social y de la comunicación, la apropiación social de conocimientos es vital porque permite generar estrategias que ponen el conocimiento en circulación con las comunidades intervenidas.
 
Una de esas estrategias generadas y estudiadas en este artículo, es lo referente a la dimensión lúdica y pedagógica, que nos permite que abrir la posibilidad de crear ambientes y contexto comunicativos diferentes de aprendizaje a través del juego como dispositivo para de transferencia y comunicación saberes producidos en los procesos de investigación con las comunidades.
 
Cabe decir, que el marco de investigación que sirve de reflexión para este documento, se ubica en el método de investigación CAPAZ (Centro Analítico de producciones culturales) de la Universidad Católica de Pereira, que orienta en sus investigaciones la aplicación del BigData y la Lexicometría automatizada para luego producir narrativas pedagógicas alrededor de las temáticas investigadas en proyectos como, 1.RUTAS (Relatos universitarios del conflicto en Colombia); 2. CANALES (La televisión digital soñada), proyectos que además, comprometen en su ADN, procesos de apropiación social de conocimientos.
Los proyectos tecnológicos como posibilidad de integración y dinamización curricular
Authors: Largo Taborda Wilson Alejandro , Zuluaga Giraldo Jorge Ivan , Borda Martínez Armando Andrés , Olarte Olarte María Eugenia
Published: May 2024

En el presente documento se presentan los hallazgos en relación con los resultados de investigación sobre el proceso de formación en la práctica pedagógica del programa de Licenciatura en Tecnología e Informática (LTI) de la Universidad Católica de Manizales (UCM). En ese sentido, la práctica pedagógica tiene como fin consolidar graduados con una visión global del mundo y que, puedan dar respuesta a las necesidades y expectativas de la comunidad en virtud de las tres funciones sustantivas que expone la universidad como son: proyección social, investigación y docencia. El objetivo del proyecto consistía en implementar proyectos tecnológicos con el fin de promover la transversalización de la tecnología e informática con otras áreas de conocimiento para fortalecer una formación integral. Se implementó una metodología cualitativa con un enfoque en el estudio de caso. Los resultados permitieron reconocer que aspectos como la motivación, el interés y el pensamiento crítico fueron algunos de los parámetros que los estudiantes señalaron a la hora de hacer referencia al aprendizaje por medio de proyectos de investigación articulados entre diversas áreas desde el análisis y comprensión del contexto. A manera de conclusión, se encontró que los estudiantes presentaron interés y acercamiento hacía los contenidos cuando se empezaron a incorporar propuestas educativas desde la incorporación de proyectos tecnológicos articulando con otras áreas del conocimiento como las matemáticas, las ciencias naturales y las ciencias sociales.
Tensiones de género en un marco de economías y políticas globalizadas en el departamento del Quindío - Colombia
Authors: De La Rosa Bobadilla Jhon Jaime , Camargo Marulanda Nataly , Diaz Arenas Pedro Felipe
Published: May 2024

En relación con la diversidad sexual y de género, se muestra como la sociedad actual aún no ha podido aceptar las diferentes orientaciones e identidades a lo largo de la historia, debido a influencias religiosas, a causa de imaginarios que denominan este tipo de expresiones como factor de alguna enfermedad mental de las personas sexualmente diversas. Mediante este estudio se pretendió analizar si las tensiones entre sexo, género y orientación sexual de la población LGBTI-OSIGD en el departamento del Quindío, influye en las oportunidades de acceso a servicios; adicionalmente, se exploró en algunas personas que asumen el liderazgo en sus comunidades, su participación en las manifestaciones públicas para la defensa de sus derechos. Para alcanzar este propósito se desarrolló un estudio de las característicasdemográficas, laborales, familiares, socioculturales, de discriminación, salud y político-institucional, mediante el método mixto; se realizó un muestreo no probabilístico intencional que estuvo constituido por sesenta y nueve personas LGBTI-OSIGD de diez municipios del departamento; se utilizó el programa de procesamiento de datos EXCEL para el análisis cuantitativo, con una aproximación a las variables de estudio. Para el componente cualitativo, se analizó un grupo de categorías (laboral, educación, salud y vivienda) que se capturó mediante entrevista a dieciséis personas con diferentes roles representativos en la comunidad, para lo cual se utilizó el procesador Atlas.ti. Mediante este trabajo se logró establecer que el mayor número de población corresponde a gais oriundos de los municipios de Pijao, Génova y Circasia, con escolaridad secundaria, de estado civil solteros, con afiliación al régimen de salud subsidiada, de ocupación independientes, de familias nucleares y que participan en Organizaciones No Gubernamentales que promueven los derechos humanos DD. HH. Con relación a la entrevista, los resultados indican que, en el aspecto laboral, la población requiere mayor apoyo en las empresas por ser persona diversa. Finalmente, se encontró que la población LGBTI-OSIGDparticipa en manifestaciones públicas, con el fin de exigir mayor oferta institucional dentro de los organismos de control público y político como la Gobernación del Quindío – Colombia.
Advanced three-dimensional in vitro liver models to study the activity of anticancer drugs
Authors: Zuchowska Agnieszka , Frojdenfal Sonia , Trzaskowski Maciej , Jastrzebska Elzbieta
Published: May 2024

The liver is one of the most important organs in the human body. It
performs many important functions, including being responsible for the
metabolism of most drugs, which is often associated with its
drug-induced damage. Currently, there are no ideal pharmacological
models that would allow the evaluation of the effect of newly tested
drugs on the liver in preclinical studies. Moreover, the influence of
hepatic metabolism on the effectiveness of the tested drugs is rarely
evaluated. Therefore, in this work we present an advanced model of the
liver, which reflects most of the morphologically and metabolically
important features of the liver in vivo, namely: three-dimensionality,
cellular composition, presence of extracellular matrix, distribution of
individual cell types in the structure of the liver model, high urea and
albumin synthesis efficiency, high cytochrome p450 activity. In
addition, the work, based on the example of commonly used anticancer
drugs, shows how important it is to take into account hepatic metabolism
in the effective assessment of their impact on the target organ, in this
case cancer.
Enfermedad por esteatosis hepática, 2023 un año de cambios: revisión en la nomenclatura, diagnóstico y tratamiento
Authors: Fernández Castro Iván , Novo-Veleiro Ignacio , Martínez de Rituerto Santiago Tomé
Published: May 2024

RESUMEN:
La enfermedad por esteatosis hepática es un problema de salud que afecta a casi un tercio de la población mundial. Hasta el año 2023 era conocida como hígado graso no alcohólico, pero esta nomenclatura se ha decidido cambiar ya que puede suponer un estigma para los pacientes y era confusa a la hora de reflejar los posibles agentes etiológicos en su desarrollo.
Los métodos diagnósticos a nuestro alcance, entre los que debemos destacar el FIB-4 y la elastografía controlada por vibración, se centran en identificar a los pacientes con una fibrosis significativa con el fin de evitar el desarrollo de una cirrosis.
Su tratamiento se basa en cambios de estilo de vida como son la pérdida de peso sostenida, la actividad de física regular, una dieta equilibrada y la abstinencia de consumo de alcohol. Medidas que se complementan con tratamientos farmacológicos aprobados para las patologías que se suelen asociar en estos pacientes, vitamina E, pioglitazonas, inhibidores de SGLT2, análogos de GLP-1 y la cirugía bariátrica.
Con esta revisión pretendemos destacar los importantes cambios en la terminología llevados a cabo, la importancia de algoritmos de diagnóstico temprano, el abordaje multidisciplinar como pilar del tratamiento y la esperanza de nuevas líneas terapéuticas contra este desafiante problema de salud.
 
ABSTRAC:
Steatosic liver disease is a prevalent health issue affecting nearly a third of the global population. Until 2023, it was known as nonalcoholic fatty liver disease (NAFLD), but this nomenclature has been altered due to potential stigmatization for patients and its lack of clarity in reflecting the possible etiological factors in its development.
FIB-4 and vibration-controlled elastography are diagnostic methods available to us, which focus on identifying patients with significant fibrosis to prevent cirrhosis development.
Lifestyle modifications, including sustained weight loss, regular physical activity, a balanced diet, and abstaining from alcohol consumption are the key to treatment. These measures are supplemented by pharmacological treatments approved for conditions commonly associated with these patients: vitamin E, pioglitazones, SGLT2 inhibitors, GLP-1 analogues, and bariatric surgery.
This review aims to underscore significant terminology changes, the importance of early diagnostic algorithms, the multidisciplinary approach as a cornerstone of treatment, and the hope for novel therapeutic avenues against this challenging health issue.
Tackling Digital Degree in Education: Optimal Use of Green Information and Communication Technology (GICT)
Authors:   1Department Computer Science, Faculty of Computing, University of Delta, Agbor. Nigeria 2Dept of Cyber Security, Delta State University of Science and Technology, Ozoro. Nigeria. 3Dept of Computer Science, Faculty of Physical Science, University of Calabar, Calabar, Nigeria., Malasowe Bridget Ogheneovo , Okpor Magaret Dumebi , Edim Bassey Edim
Published: May 2024

The COVID-19 pandemic has resulted in a significant increase in the use of Information and Communication Technology (ICT) in all areas of the education sector, particularly in developed economies as well as developing countries, regardless of preparedness. This is because, under the new normal, ICT adoption has become ubiquitous and fast-moving, even in the face of impending challenges. In the case of education, in particular, the disruption caused by the pandemic has caused ICT to become an instantaneous apparatus that has sustained the teaching and learning sector during the global lockdown that ravaged the world between 2019 and 2020, with consequences that are still visible today. Once more, the pandemic's outbreak made it clear to world leaders in numerous developing nations that they had no option but to use an ICT tool that was accelerating the growth of their countries' national knowledge bases. Notwithstanding the apparent difficulties integrating ICT into teaching and learning, the COVID-19 pandemic's effects accelerated the spread of ICT, forcing teachers and students in Nigeria and, in fact, around the world, to work online despite their readiness in terms of knowledge, abilities, and resources. In today's globalized world, ICT has become indispensable in filling gaps in the education sector, but it is also important to recognize the role of green information technology. This study examined how ICT instantly filled in the educational gaps during a pandemic-related lockdown, as well as how Green IT impacts our ecology. In order to truly close the digital divide that existed in the education sector in today's carefree world, the research has supplied the essential information and details, as well as recommendations for how to best use ICT tools to secure the ecosystem. Keywords: ICT, Covid -19 Pandemic, Green IT, Digital Divide. Aims Research Journal Reference Format: Malasowe, B.O., Okpor, M.D. & Edim, B.E. (2024): Tackling Digital Degree in Education: Optimal Use of Green Information and Communication Technology (GICT). Advances in Multidisciplinary and Scientific Research Journal Vol. 10. No. 1. Pp 67-76. www.isteams.net/aimsjournal. dx.doi.org/10.22624/AIMS/V10N1P5
Elevated cathepsin S serum levels in new-onset type 1 diabetes and autoantibody-positive siblings
Authors: Frørup Caroline , Høj Jensen Mathias , Haupt-Jorgensen Martin , Buschard Karsten , Størling Joachim , Pociot Flemming , Fløyel Tina
Published: May 2024

Accumulating data suggest a role for the lysosomal protease cathepsin S (CTSS) in type 1 diabetes. Circulating CTSS is increased in type 1 diabetes; however, whether CTSS has protective or deleterious effects is unclear. The study’s objectives were to examine the biomarker potential of CTSS in new-onset type 1 diabetes, and to investigate the expression and secretion of CTSS in human islets and β cells. The CTSS level was analyzed in serum from children with new-onset type 1 diabetes and autoantibody-positive and -negative siblings by ELISA. The expression and secretion of CTSS were evaluated in isolated human islets and EndoC-βH5 cells by real-time qPCR, immunoblotting, and ELISA. The CTSS serum level was elevated in children with new-onset type 1 diabetes and positively associated with autoantibody status in healthy siblings. Human islets and EndoC-βH5 cells demonstrated induction and secretion of CTSS after exposure to pro-inflammatory cytokines, a model system of islet inflammation. Analysis of publicly available single-cell RNA sequencing data on human islets showed that elevated CTSS expression was exclusive for the β cells in donors with type 1 diabetes as compared to non-diabetic donors. These findings suggest a potential of CTSS as a diagnostic biomarker in type 1 diabetes.
Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study)
Authors: Kinos Sampsa , Hagman Helga , Halonen Päivi , Soveri Leena-Maija , O'Reilly Mary , Pfeiffer Per , Frödin Jan-Erik , Sorbye Halfdan , Heervä Eetu , Liposits Gabor , Kallio Raija , Ålgars Annika , Ristamäki Raija , Salminen Tapio , Bärlund Maarit , Shah Carl-Henrik , McDermott Ray , Röckert Rebecka , Flygare Petra , Kwakman Johannes , Teske Arco , Punt Cornelis , Glimelius Bengt , Österlund Pia
Published: May 2024

Background and purpose: The CardioSwitch-study demonstrated that patients with solid tumors who develop cardiotoxicity on capecitabine or 5-fluorouracil (5-FU) treatment can be safely switched to S-1, an alternative fluoropyrimidine (FP). In light of the European Medicines Agency approval of S-1 in metastatic colorectal cancer (mCRC), this analysis provides more detailed safety and efficacy information, and data regarding metastasectomy and/or local ablative therapy (LAT), on the mCRC patients from the original study.
Materials and methods: This retrospective cohort study was conducted at 12 European centers. The primary endpoint was recurrence of cardiotoxicity after switch. For this analysis, safety data are reported for 78 mCRC patients from the CardioSwitch cohort (N = 200). Detailed efficacy and outcomes data were available for 66 mCRC patients.
Results: Data for the safety of S-1 in mCRC patients were similar to the original CardioSwitch cohort and that expected for FP-based treatment, with no new concerns. Recurrent cardiotoxicity (all grade 1) with S-1-based treatment occurred in 4/78 (5%) mCRC patients; all were able to complete FP treatment. Median progression-free survival from initiation of S-1-based treatment was 9.0 months and median overall survival 26.7 months. Metastasectomy and/or LAT was performed in 33/66 (50%) patients, and S-1 was successfully used in recommended neoadjuvant/conversion or adjuvant-like combination regimens and schedules as for standard FPs.
Interpretation: S-1 is a safe and effective FP alternative when mCRC patients are forced to discontinue 5-FU or capecitabine due to cardiotoxicity and can be safely used in the standard recommended regimens, settings, and schedules.
Health complaints before and at one and five years after removal of dental amalgam restorations – data from a prospective cohort study in Norway
Authors: Sinha Nivedita , Hamre Harald Johan , Musial Frauke , L. Werner Erik , Björkman Lars
Published: May 2024

Objective: Health complaints attributed to dental amalgam fillings comprise both intraoral and general health complaints. There are data suggesting that patients with medically unexplained physical symptoms (MUPS) attributed to amalgam fillings show improvement in symptoms after removal of all amalgam fillings. However, data indicating changes of specific health complaints are limited. This study evaluated the changes of health complaints after removal of amalgam restorations in patients with health complaints attributed to dental amalgam fillings.
Method: Patients with MUPS attributed to dental amalgam (Amalgam cohort) had all their amalgam fillings removed. The participants indicated an intensity of 11 local and 12 general health complaints on numeric rating scales before the treatment and at follow-up after 1 and 5 years. The comparison groups comprising a group of healthy individuals and a group of patients with MUPS without symptom attribution to dental amalgam did not have their amalgam restorations removed.
Results: In the Amalgam cohort, mean symptom intensity was lower for all 23 health complaints at follow-up at 1 year compared to baseline. Statistically significant changes were observed for specific health complaints with effect sizes between 0.36 and 0.68. At the 5-year follow-up, the intensity of symptoms remained consistently lower compared to before the amalgam removal. In the comparison groups, no significant changes of intensity of symptoms of health complaints were observed.
Conclusion: After removal of all amalgam restorations, both local and general health complaints were reduced. Since blinding of the treatment was not possible, specific and non-specific treatment effects cannot be separated.
The impact of systemic administration of polyphenols on periodontitis associated with diabetes mellitus: a systematic review
Authors: Rogalnikovaite Kornelija , Antipoviene Auste , Burbulyte Asta , Bendoraitiene Egle Aida
Published: May 2024

Objective: The aim of this work was to explore the potential of polyphenol supplement consumption in enhancing the treatment of periodontitis and diabetes mellitus in both diabetic animals and humans.
Materials and methods: A comprehensive search across eight databases (MEDLINE, EBSCO, Taylor & Francis, PRIMO, Web of Science, Wiley Online Library, ScienceDirect, and SAGE Journals) and two registers (ClinicalTrials.gov and Cochrane Library Trials) was conducted. Methodological quality assessment employed the Cochrane Collaboration Risk of Bias Assessment Tool for randomised controlled trials and the Systematic Review Centre for Laboratory Animal Experimentation Risk of Bias Tool for experimental animal studies.
Results: Ten articles meeting inclusion criteria were identified. Three clinical studies demonstrated significant reductions in probing depth (PD) and clinical attachment loss (CAL). Ginger supplementation showed a decrease in CAL (–0.57 ± 0.50 vs. –0.14 ± 0.35, p = 0.003) and PD (–0.52 ± 0.51 vs. –0.19 ± 0.51, p = 0.04), while resveratrol supplementation exhibited a reduction in PD (–1.1 ± 0.58 vs. –0.6 ± 0.47, p < 0.001). Additionally, cranberry juice supplementation led to a decrease in PD (–0.56 ± 0.03, p < 0.001). However, there was no significant improvement in inflammation status. Although polyphenol supplementation did not impact fasting blood glucose levels, it did result in improved insulin resistance (3.66 ± 0.97 vs. 4.49 ± 1.56, p = 0.045). In diabetic animals, six studies reported a significant reduction (p < 0.05) in bone loss along with marked improvements in inflammation status.
Conclusions: Despite the promising results observed in the included studies, the overall evidence supporting the positive effects of polyphenols on periodontal and diabetes mellitus status, along with their anti-inflammatory properties, remains inadequate.
Taxonomic report of filamentous fungi presents in sewage waste sludge with biotechnologi-cal potential
Authors: Gutiérrez-Anzueto Brenda Irais , Mora-Ravelo Sandra Grisell , González-Mendoza Daniel , Reyes Zepeda Francisco , Rosas-Mejía Madai
Published: May 2024

There is few information regarding the identification of filamentous fungi present in sewage sludge, the importance of these microorganisms lies in the potential use they have in the food, pharmaceutical and agri-environmental industries as they are beneficial in the remediation of water, sludge and soil contaminated by Heavy metals and hydrocarbons also contribute to the adsorption of nutrients by crops. The use of residual sludge once decontaminated by these microorganisms can be used in agriculture as soil structure improvers, organic fertilizers and as an amendment to prevent soil erosion. The objective of this research was to characterize and identify fast and medium-growing filamentous fungi from sewage sludge. The residual sludge was collected directly from the thickness of the municipal water treatment plant of Cd. Victoria, Tamaulipas, Mexico. Subsequently, the fungi were isolated on agar plates and identified using morphological characters of the colonies and by PCR and diana sequences. The species identified were: Trichoderma longibrachiatum, Aspergillus terreus, Tylopilus porphyrosporus and Aspergillus fumigatus. Being the first report for Mexico of fungal species that grow in residual sludge from water treatment plants. The molecular characterization of the species of filamentous fungi found in sewage sludge will allow progress in research focused on knowing the advantages and biological and chemical mechanisms of these microorganisms for the development of biotechnological processes and products, with high agricultural potential and environmental.
Hepatic Cirrhosis and its Management via Electro-Homoeopathic Practices
Authors: S* Mishra
Published: May 2024

Hepatic cirrhosis is known by the development of regenerative nodules in liver parenchyma surrounded by fibrous septa resultant to chronic liver damage. Cirrhosis happens due to necrosis of liver cells followed by fibrosis and nodule formation. The liver organization come to be abnormal and interferes with liver blood flow and function, and eventually pointers to portal hypertension followed by hepatocytic dysfunction. Chronic liver diseases signify a remarkable health problem across the world with liver cirrhosis. The exact prevalence of cirrhosis worldwide was ambiguous due to the clinical continuum ranging from apathetic, asymptomatic to whole liver decompensation. Therefore, recurrent inputs via a series of research in view of various conventional and definite earlier techniques in background, along this thrust medical area, directed an emerging and medically most precise an alternate technique, namely, Electro-Homoeopathic Medical Science that has been presently in practice by a number of practitioners in India and southeast Asian countries enlightening attractive outcome without any significant post therapeutic physiological and/or biochemical side effect concomitant with risk factor. Various clinical practices and survey provide new insights into the development and establishment of an increasingly advanced form of the electro-homeopathic system for a defined diagnosis enlightening a definite root cause and efficient management of Liver Disease as well as its perception.
Bird eye view of saphenous incompetence from a veteran of angiology
Authors: Allegra Claudio
Published: May 2024

Conversation with Claudio Allegra, a "veteran" of angiology, a protagonist of all the seasons of Phlebology, former President of the International Union of Phlebology (IUP) and of the International Union of Angiology (IUA). A chat with Stefano Ricci.
Revisit to Phlebolymphedema as Ultimate Outcome of Dual Outflow System Failure
Authors: Lee Byung Boong
Published: May 2024

Venous and lymphatic systems are one interdependent, ‘inseparable’ dual-outflow system of the circulation. Both systems are ‘mutually complimentary’; the insufficiency or overload to one of two systems allows the other to play an auxiliary role of fluid return through micro- & macro-anastomosis.

But both systems are ‘mutually complimentary’ only when they are with normal function; when the venous stasis exceeds this maximum lymphatic compensatory capacity, the insufficiency becomes ‘phlebo-lymphatic’. When one of the two systems should fail to provide sufficient compensation to the other system, it would become a combined condition of chronic venous insufficiency (CVI)/chronic venous hypertension and chronic lymphatic insufficiency (CLI)/chronic lymphedema, known as “phlebo-lymphedema” (PLE).

Hence, the ulcer of PLE origin represents an unavoidable outcome of the joint failure of this “inseparable” venous-lymphatic circulation system, presenting as a combined condition of veno-lymphatic edema caused by CVI and CLI. When the lymphatic system becomes damaged (mechanical insufficiency) or the ultrafiltrate load becomes greater than the ability of the lymphatic system to drain it (dynamic insufficiency), the lymphatic system would fail to handle the interstitial fluid load, and the proteins and macromolecules start to accumulate in the interstitium.

This ‘presence of proteins in the interstitial space’ further induces an inflammatory cascade to create a proinflammatory state leading to the irreversible changes. These proteins may serve further as a substrate for microorganisms to facilitate extending and intensifying infections. Increased scarring and trauma by these infections cause further damage to the vulnerable lymphatic collectors.

Therefore, lymphatic system can be easily damaged not only by drainage overload but also by the inflammatory environment created by the fluid stasis so that this vicious circle created by the impairment of the venous and lymphatic system would cause the ulcer management more seriously complicating. Hence, a precise understanding of the nature of all the chronic ‘indolent’ venous stasis ulcers as a combined condition of veno-lymphatic edema caused by CVI and CLI of various origins is mandated based on simultaneous evaluation of these two closely linked conditions/systems.
Phlebolymphedema and bioimpedance: general concepts and personal experience
Authors: Cavezzi Attilio , Colucci Roberto , Cavezzi Sara , Paccasassi Stefania
Published: May 2024

Limb phlebolymphedema (PLE) is characterized by an accumulation of fluid in the interstitial space and it is caused by an impairment of venous and lymphatic flow. From the pathophysiology point of view, PLE may be of primary and (more frequently) secondary type; it mostly occurs in post-thrombotic syndrome, after trauma, in varicose veins with dysfunctional centripetal flow pumping mechanisms, in proximal vein obstruction syndromes (e.g. May-Thurner syndrome), in phlebolymphatic congenital malformations (e.g. Klippel Trenaunay syndrome).
To improve diagnostics of limb PLE, bioimpedance technology has been proposed, both under the form of bioimpedance analysis and under the form of the more accurate bioimpedance spectroscopy (BIS); the latter is based on multiple frequencies which investigate tissues with a higher degree of accuracy, compared to bioimpedance analysis which is usually based on one or two frequencies. By means of BIS it is possible to measure and monitor the variations in the extracellular (interstitial) and intracellular fluids as well as in the tissue composition.
More importantly, this biotechnology permits a segmental assessment of the edema, thus both limbs may be individually investigated, as well as the fluid accumulation/tissue conditions of the single limb or part of it may be assessed. Similarly, this method may contribute to monitor therapy outcomes and it may also have a relevant prognostic role after oncologic therapy (e.g. breast cancer treatment) to anticipate the risk of lymphedema/PLE onset.
Beside the classical L-Dex index which compares the two limbs in terms of impedance, the analysis of raw data permits to extrapolate absolute figures concerning a series of relevant parameters such as: a) resistance which is the expression of the extracellular fluids, b) reactance and c) cell membrane capacitance (CMC) which are both indexes of tissue composition/health.
Furthermore, BIS provides a wide range of data concerning body composition in terms of fat and lean mass, water and general health (for example through phase angle index); this way, a more comprehensive approach to the possible concomitant chronic diseases (e.g. obesity, cardiovascular diseases, diabetes, cancer) in the PLE patient is pursued.
Report on the international congress 'Lymphedema and Lipedema across borders: comparing experiences'
Authors: Onorato Alberto , Galli Tiziana , Macciò Alberto
Published: May 2024

The report of the scientific conference held in Trieste on 5 and 6 April 2024, on topics relating to lymphedema and lipedema, is presented. Aspects relating to what is provided by the health services of 6 European countries were addressed. Various innovative diagnostic and therapeutic approaches were then presented. Finally, aspects relating to chronic diseases were discussed, with regard to new concepts and professional figures. Other particular topics completed the program.
Aircraft Performance Simulation of 19-Passenger Commuter Aircraft: A Comparison between Normal and Amphibious Category
Authors:   Mechanical Engineering, Department of Mechanical Engineering, Universitas Indonesia, Depok 16424, West Java, INDONESIA, Adhitya M.
Published: May 2024

This article presents calculating flight performance aspects and simulations of flight characteristics during a flight mission of the 19-passenger commuter aircraft, with a focus on the comparison between the normal and amphibious category aircraft. The objective is to analyse the flight characteristics (warm up, takeoff, cruise, descent, landing) and capabilities of both aircraft configurations. The significant difference between the two aircraft lies in the presence of float components in the 19-passenger Amphibious aircraft. The calculation process, both manual and simulation-based, involves utilizing constraint analysis and mission analysis to determine the weight fraction values for each flight phase. The results of the constraint analysis indicate that the amphibious category aircraft has higher values (35% - 80%) compared to the normal category aircraft. Meanwhile, the calculations using aircraft engine design (AEDsys) software reveal nearly identical reductions in weight fraction for each phase, with the amphibious category aircraft having a significant decrease in the final weight fraction of 0.87836. The fuel weight used is 2129 lb or 965.70 kg (8 barrels) with a range of approximately 372 nm or about 690 km and a flight time of approximately 2.4 hours. The drag polar values obtained using Parametric cycle analysis software at an altitude of 3,048 meters (10,000 ft) show that the normal category aircraft has a smaller coefficient drag (CD) value. Further validation of the findings from this performance simulation study can be conducted through direct experimental validation during flight to be utilized for optimizing aircraft performance.
Defect Recognition Method for Magnetic Leakage Detection in Oil and Gas Steel Pipes Based on Improved Neural Networks
Authors: Mohd. Shah Mohd. Kamal
Published: May 2024

The aging infrastructure of petroleum and natural gas pipelines poses a threat to national economies, necessitating precise defect detection for safety and efficiency. To enhance the accuracy of predicting pipeline defect sizes, this study introduces a magnetic leakage detection system, employing Backpropagation (BP) neural networks optimized with genetic algorithms. Traditional BP networks face challenges, including parameter determination and slow convergence, addressed through genetic algorithms' global search capabilities. Simulated data are generated using ANSYS software by using models of semi-circular defects in steel pipes, producing magnetic leakage signals of varying intensities. MATLAB was used to construct both standard BP and genetically optimized BP neural networks. Results show that the latter significantly reduces computational errors, demonstrating improved accuracy in defect dimension prediction. The approach contributes to overcoming non-uniqueness in the recognition process and the complex nonlinear relationship between magnetic signals and defect size parameters. The study offers a guided approach for selecting BP neural network parameters, enhancing practicality. Simulations validate the method's effectiveness, indicating low workload and high reliability. This research provides a meaningful advancement in the detection of defects in long-distance pipelines, impacting the safety and efficiency of petroleum and natural gas transportation.
Evaluating the Structural Response of Ceramic-Metal Laminate under Ballistic Impact
Authors:   School of Mechanical Engineering, College of Engineering, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, MALAYSIA, Meon Mohd Suhairil
Published: May 2024

Ceramics are widely employed in armor because of their toughness, but their susceptibility to fractures under high-speed impact poses a challenge. To address this gap, a comprehensive investigation using finite element analysis is undertaken. This study aims to understand the combined behaviour of ceramics and backing plates during ballistic impact. Using ABAQUS software, a range of simulations are conducted involving circular ceramics paired with different types of backing plate, considering varying impact energies. The results revealed that the integrity of the ceramic-metal laminate structure is highly dependent on the laminate configurations. From four combinations of hybrid laminates, the combination of boron carbide with Armox 500T as the backing plate produced an outstanding result based on the structural response analysed in this work. The key results obtained provide valuable insights into the response of ceramic-armored configurations, filling a critical knowledge gap.
Influence of Alkali Treatment on Bamboo/Coconut Husk Hybrid Fibre Polyester Composite
Authors:   School of Chemical Engineering, College of Engineering, Universiti Teknologi MARA, Selangor, MALAYSIA, Sapiee Nurul Haiza
Published: May 2024

This research addresses the importance of hybrid composites in material science, specifically, demonstrating the effective reinforcement of unsaturated polyester with bamboo and coconut husk fibre through alkali treatment. The primary problem this work aims to solve is the improvement of the mechanical properties of unsaturated polyester by combining it with bamboo and coconut husk fibres which contain both lignocellulosic and cellulose fibres. Alkali treatment, particularly, sodium hydroxide (NaOH) solution, was used in this study due to its cost-effective nature and its ability to enhance the strength of both individual fibres and resulting composite. The effect of NaOH treatment with concentrations ranging from 2 – 10 wt.% on dried hybrid fibres was investigated. Chemically treated fibre composites were discovered to have improved mechanical characteristics as both tensile tests and thermogravimetric analysis (TGA) showed higher strength and thermal stability after being treated. Notably, findings identified an optimal content of 8 wt.% NaOH solution for surface modification, showcasing the potential for using NaOH-treated waste fibres to reinforce polyester resin. The implications of this study extend to a promising avenue for enhancing the performance and application of natural fibre-reinforced composites. The insights provided here offer a foundation for advancing the utilization of hybrid composites.