bluuebunny/crossref_metadata_2025 huggingface dataset:
Building integral projection models with non-independent vital rates
Authors: Fung Yik Leung , Newman Ken , King Ruth , Valpine Perry de
Published: November 2021

Population dynamics are functions of several demographic processes
including survival, reproduction, somatic growth, and maturation. The
rates or probabilities for these processes can vary by time, by
location, and by individual. These processes can co-vary and interact to
varying degrees, e.g., an animal can only reproduce when it is in a
particular maturation state. Population dynamics models that treat the
processes as independent may yield somewhat biased or imprecise
parameter estimates, as well as predictions of population abundances or
densities. However, commonly used integral projection models (IPMs)
typically assume independence across these demographic processes. We
examine several approaches for modelling between process dependence in
IPMs, and include cases where the processes co-vary as a function of
time (temporal variation), co-vary within each individual (individual
heterogeneity), and combinations of these (temporal variation and
individual heterogeneity). We compare our methods to conventional IPMs,
which treat vital rates independent, using simulations and a case study
of Soay sheep (Ovis aries). In particular, our results indicate that
correlation between vital rates can moderately affect variability of
some population-level statistics. Therefore, including such dependent
structures is generally advisable when fitting IPMs to ascertain whether
or not such between vital rate dependencies exist, which in turn can
have subsequent impact on population management or life-history
evolution.
Antibiotic-induced depletion of gut microbiota increases systemic exposure of clopidogrel active metabolite in type 2 diabetic rats
Authors: Chen Xue , Liu Yingrui , Yao Hongwei , Song Wenfang , Pan Meng , Song Yu , Gu Jingkai , Guo Yingjie
Published: November 2021

Background and Purpose: The current study investigated whether the
manipulation of gut microbiome through treatment with an antibiotic
cocktail can alter the bioavailability of clopidogrel active metabolite
(Clop-AM) in T2DM rats. Experimental Approach: Control and T2DM rats
were orally administered with either vehicle or an antibiotic cocktail
containing ampicillin, neomycin, metronidazole, and vancomycin for 5
consecutive days. The levels of clopidogrel (Clop) and its metabolites
were measured by LC-MS/MS. Biochemical parameters, liver microsome
metabolism, mRNA, protein or activity of Clop- metabolizing enzymes and
transporter, and 16S rRNA sequence of fecal samples were analyzed to
explain any altered pharmacokinetic profile of Clop-AM. Key Results:
Antibiotic administration markedly alleviated T2DM rats’ phenotypes
including hyperglycemia, hyperlipidemia, insulin resistance, liver
dysfunction and inflammation. Meanwhile, the reduced systemic exposure
of Clop-AM in T2DM rats as compared to control rats was significantly
reversed after antibiotic treatment, accompanied with the decreased
expression of P-glycoprotein (P-gp) in small intestine, suggesting
P-gp-based Clop absorption might be promoted, consequently making more
Clop available for Clop-AM formation. Interestingly, fecal microbiome
analysis exhibited the reduced microbial amount and the altered
microbial composition in antibiotic-treated T2DM rats. Especially, there
was an inconsistent change of P-gp levels between T2DM rats and SW480
cells after antibiotic treatment, suggesting antibiotic-induced
microbiome depletion, not the direct role of antibiotics is associated
with the enhanced Clop-AM plasma exposure in T2DM rats. Conclusion and
Implication: The findings show that gut microbiota modulation is an
effective therapeutic strategy to enhance Clop-AM generation under T2DM
conditions.
Some integral inequalities via (p,q)-calculus on finite intervals
Authors: Tunç Mevlüt , Göv Esra
Published: November 2021

The aim of this paper is to construct (p,q)-calculus on finite
intervals. The (pk,qk)-derivative and (pk,qk)-integral are
defined and some basic properties are given. Also, (pk,qk)-analogue of
H?lder, Minkowski integral inequalities are proved.
Compact ADI method for two-dimensional Riesz space fractional diffusion equation
Authors: Valizadeh Sohrab , Malek Alaeddin , Borhanifar Abdollah
Published: November 2021

In this paper, a compact alternating direction implicit (ADI) method has been
developed for solving two-dimensional Riesz space fractional diffusion
equation. The precision of the discretization method used in spatial
directions is twice the order of the corresponding fractional derivatives.
It is proved that the proposed method is unconditionally stable via the
matrix analysis method and the maximum error in achieving convergence is
discussed. Numerical example is considered aiming to demonstrate the
validity and applicability of the proposed technique.
Global optimal approximate solutions of best proximity points
Authors: Haddadi Mohammad , Parvaneh Vahid , Mursaleen Mohammad
Published: November 2021

In this paper, we introduce the concept of contractive pair maps and give
some necessary and sufficient conditions for existence and uniqueness of best
proximity points for such pairs. In our approach, some conditions have been
weakened. An application has been presented to demonstrate the usability of
our results. Also, we introduce the concept of cyclic ?-contraction and
cyclic asymptotic ?-contraction and give some existence and convergence
theorems on best proximity point for cyclic ?-contraction and cyclic
asymptotic ?-contraction mappings. The presented results extend, generalize
and improve some known results from best proximity point theory and
fixed-point theory.
Gaussian Pell and Gaussian Pell-Lucas quaternions
Authors: Arslan Hasan
Published: November 2021

The main aim of this work is to introduce the Gaussian Pell quaternion QGpn
and Gaussian Pell-Lucas quaternion QGqn, where the components of QGpn and
QGqn are Pell numbers pn and Pell-Lucas numbers qn, respectively. Firstly,
we obtain the recurrence relations and Binet formulas for QGpn and QGqn. We
use Binet formulas to prove Cassini?s identity for these quaternions.
Furthermore, we give some basic identities for QGpn and QGqn such as some
summation formulas, the terms with negative indices and the generating
functions for these complex quaternions.
α-ψ-contractive type mappings on quasi-metric spaces
Authors: Romaguera Salvador , Tirado Pedro
Published: November 2021

We introduce and discuss several types of ?-?-contractive mappings on
quasi-metric spaces. We obtain some fixed point theorems in this setting and
present suitable examples to show the validity of our approach and results.
Finally, we give a characterization of doubly Hausdorff right K-sequentially
complete quasi-metric spaces in terms of ?-?-contractive type mappings
having fixed point.
Certain parameterized inequalities arising from fractional integral operators with exponential kernels
Authors: Yuan Zhengrong , Zhou Taichun , Zhang Qiang , Du Tingsong
Published: November 2021

We utilize the definition of a fractional integral operators, which was
presented by Ahmad et al., to investigate a general fractional-type identity
with a parameter. We establish certain parameterized fractional integral
inequalities based on this identity, and provide two examples to illustrate
the obtained results. Also, these results derived in this paper are applied
to the estimations of q-digamma function, divergence measures and cumulative
distribution function, respectively.
General decay and well-posedness of the Cauchy problem for the Jordan-Moore-Gibson-Thompson equation with memory
Authors: Boulaaras Salah , Choucha Abdelbaki , Ouchenane Djamel
Published: November 2021

In this paper, we consider the Cauchy problem of a third order in time
nonlinear equation known as the Jordan-Moore-Gibson-Thompson (JMGT) equation
with the presence of both memory. Using the well known energy method
combined with Lyapunov functionals approach, we prove a general decay
result, and we show a local existence result in appropriate function spaces.
Finally, we prove a global existence result for small data, and we prove the
uniqueness of the generalized solution.
Analysis of a fractional tumor-immune interaction model with exponential kernel
Authors: Dokuyucu Mustafa , Dutta Hemen
Published: November 2021

In this paper, a tumor-immune interaction model has been analyzed via
Caputo-Fabrizio fractional derivative operator with exponential kernel.
Existence of solution of the model has been established with a fixed-point
method and then it demonstrated the uniqueness of solution also. The
stability of the model has been analyzed with the help of Hyers-Ulam
stability approach and then numerical solution by using the Adam-Basford
method. The results are further examined in detail with simulations for
different fractional derivative values.
Some extended Berezin number inequalities
Authors: Sahoo Satyajit , Bakherad Mojtaba
Published: November 2021

We present generalized extensions of Berezin number inequalities involving
the Euclidean Berezin number and f-connection of operators.
New classes of preinvex functions and variational-like inequalities
Authors: Noor Muhammad , Noor Khalida
Published: November 2021

In this paper, we define and introduce some new concepts of the higher order
strongly generalized preinvex functions and higher order strongly monotone
operators involving the arbitrary bifunction and function. Some new
relationships among various concepts of higher order strongly general
preinvex functions have been established. It is shown that the optimality
conditions of the higher order strongly general preinvex functions are
characterized by a class of variational inequalities, which is called the
higher order strongly generalized variational-like inequality. Auxiliary
principle technique is used to suggest an implicit method for solving higher
order strongly generalized variational-like inequalities. Convergence
analysis of the proposed method is investigated using the
pseudo-monotonicity of the operator. It is shown that the new parallelogram
laws for Banach spaces can be obtained as applications of higher order
strongly affine generalized preinvex functions, which is itself a novel
application. Some special cases also discussed. Results obtained in this
paper can be viewed as refinement and improvement of previously known
results.
Two extensions of the stone duality to the category of zero-dimensional Hausdorff spaces
Authors: Dimov Georgi , Ivanova-Dimova Elza
Published: November 2021

Extending the Stone Duality Theorem, we prove two duality theorems for the
category ZHaus of zero-dimensional Hausdorff spaces and continuous maps. They
extend also the Tarski Duality Theorem; the latter is even derived from one
of them. We prove as well two new duality theorems for the category EDTych of
extremally disconnected Tychonoff spaces and continuous maps. Also, we
describe two categories which are dually equivalent to the category ZComp of
zero-dimensional Hausdorff compactifications of zero-dimensional Hausdorff
spaces and obtain as a corollary the Dwinger Theorem about zero-dimensional
compactifications of a zero-dimensional Hausdorff space.
On the existence and Ulam-Hyers stability of a new class of partial (Φ,χ)-fractional differential equations with impulses
Authors: Seemab Arjumand , Rehman ur Mujeeb , Feckan Michal , Alzabut Jehad , Abbas Syed
Published: November 2021

In this paper, we consider the newly defined partial (?,?)-fractional
integral and derivative to study a new class of partial fractional
differential equations with impulses. The existence and Ulam-Hyers stability
of solutions for the proposed equation are investigated via the means of
measure of noncompactness and fixed point theorems. The presented results
are quite general in their nature and further complement the existing ones.
Intrinsic resistivity of sintered Nickel Manganite vs. powder activation time and density
Authors: Savic S.M. , Nikolic M.V. , Aleksic O.S. , Slankamenac M. , Zivanov M. , Nikolic P.M.
Published: November 2021

In this work the DC resistivity of sintered nickel manganite NiMn2O4 (NTC thermistor material) was studied as a function of additional powder activation time in a planetary ball mill (0, 5, 15, 30, 45 and 60 min). The activated powders and non-activated powder were sintered at different temperatures (900, 1050 and 12000C) for an hour. Structural changes were analyzed using XRD. Sample density, porosity and DC resistivity were measured on the same sintered samples. Correlations between sample density, porosity, and intrinsic DC resistivity vs. additional powder activation time and the sintering temperature were made. It was noticed that the resistivity falls with the increase of sample density (or increase of the sintering temperature).
AN ANALYSIS OF CODE SWITCHING IN BILINGUAL SCHOOL IN COMMUNICATION BY NON-NATIVE SPEAKER ENGLISH TEACHER IN BALI
Authors: Ria Zenitha Ni Putu
Published: November 2021

Abstract This study aimed at investigating types of code-switching pattern which used by non-native speaker English teacher and the reason to use the code-switching. This research was a descriptive qualitative research. There were 3 informant samples from non native speaker English speaker in a bilingual school in Bali. The data were collected by using observation and interview. The results showed that, 1) there is an indication of insertion and alternation which occurred by non native speaker English during communication and mostly in the form of simple imperative and instructional utterances, and 2) the reason to use the code switching is to introduce the students the habit of using English
THE SURVEY OF NORTH BALI PRIMARY SCHOOL STUDENTS’ ATTITUDE TOWARD EFL
Authors: Pradipta Tia Dwi
Published: November 2021

This study aimed for investigating the primary students attitude toward EFL . The  study employed a quantitative design in which the data were collected by means of a survey method. The context of the study was in one of primary schools in North Bali. The survey questionnaire was developed based on Wutz and Wedwick (2005) which shows the aspects of attitude. It can was found out that the primary students’ demonstrate moderate attitude toward EFL. They were neither notably motivated nor unmotivated in learning English as a Foreign Language at school. This needs further studies to explore factors that could improve the quality of EFL classes in primary schools
THE EFFECT OF SCAFFOLDING STRATEGY ON LEARNER AUTONOMY AND WRITING COMPETENCY OF THE TENTH GRADE STUDENTS OF SMA N 1 SEMARAPURA IN THE ACADEMIC YEAR 2019/2020
Authors: Eka Maryantini Ni Wayan , Ngurah Marhaeni Anak  Agung Istri , Eka Sulistia Dewi Ni Luh Putu
Published: November 2021

This study aimed to investigate the effect of scaffolding strategy on learner autonomy and writing competency. This study was conducted in SMA N 1 Semarapura in the academic year 2019/2020 in form of experimental study with Post-Test Only Control Group Design. The population of this study was 368 tenth grade students, wherein two classes which consisted of 66 students were selected by using lottery to determine experimental group and control group as the sample of this study through Cluster Random Sampling Technique. The students of experimental group were treated by using scaffolding strategy and the students of control group were treated by using conventional writing strategy. The data of learner autonomy were collected by using questionnaire, the data of writing competency were collected by using rubric, and then the data were analyzed by using multivariate variance test (MANOVA). The result of this study showed that: (1) scaffolding strategy affected better than conventional writing on learner autonomy, (2) scaffolding strategy affected better than conventional writing on writing competency, and (3) simultaneously, scaffolding strategy affected better than conventional writing on learner autonomy and writing competency. These findings have important contribution to EFL pedagogy in general and in teaching and learning writing in particular. It can be concluded that scaffolding strategy gives positive effect on learner autonomy and writing competency separately and simultaneously.Key Words : learner autonomy, scaffolding strategy, writing competency.
Exploring the Potential Use of Telehealth Technology to Improve the Diagnostic Process of Autism Spectrum Disorder (ASD) in Wales, United Kingdom
Authors:   , Alfuraydan Manahil M.
Published: November 2021

There is a significant delay between parents initially seeking help and receiving a diagnosis of Autism Spectrum Disorder (ASD). Telehealth has the potential to accelerate the ASD diagnostic pathway. However, user acceptance is essential for the successful implementation of telehealth technology. This thesis therefore aims to examine whether telehealth can be used to increase access to ASD diagnostic services in Wales and reduce the time taken to receive a diagnosis. To achieve this, a multimethod approach was adopted, comprising of three studies. Initially, a scoping review (Study1) was conducted examining the use of telehealth in ASD diagnostic assessment. This identified two methods: (a) Real-Time (b) Store-and-Forward, particularly the Naturalistic Observation Diagnostic Assessment (NODA) system. Results also suggest that telehealth is feasible and acceptable to the families. However, findings indicate that no study had thus far examined the factors of telehealth acceptance, based on theoretical foundation. Therefore, Studies two and three were conducted, to explore the parental experience of the diagnostic process, and investigate the predictors of their acceptance to use NODA for ASD diagnostic assessment, using the Unified Theory of Acceptance and Use of Technology model. Data for both studies was collected via an online questionnaire, targeting parents of children with ASD in Wales. Descriptive and inferential statistics were applied to the closed-ended questions, and thematic analysis was used for open-ended questions. Study 2 findings revealed that the majority of parents were dissatisfied with the diagnostic process, with the time taken to obtain a diagnosis being a predictor of their satisfaction. Study 3 found that the majority of parents felt positively towards the NODA, with their willingness to use the system being predicted by their age, performance expectancy, social influence and comfort with using laptop and smartphone devices. Implications and recommendations are further discussed at the end of the thesis.
Assessment of drinking water quality within amalgamated territorial communities
Authors:   Polissia National University, Valerko Ruslana , Herasymchuk Liudmyla ,   Polissia National University, Hurskyi Yevgenii ,   Polissia National University, Pavlenko Anastasiya ,   Polissia National University
Published: November 2021

One of the main problems of rural residential areas is to provide the local population with quality drinking water, which is a major factor influencing their health. To solve this problem, it is necessary to implement effective measures not only at the state level but also at the regional and local levels. The main purpose of decentralization of power is to transfer the power and appropriate financial resources to the lowest levels of local self-government, which makes it possible for created amalgamated communities to use these resources to solve the priority issues. However, to determine the ecological state of rural settlements in the subsystem of drinking water quality, it is necessary to assess its quality in the territory where the community is situated. The investigation was carried out in 15 rural settlements of the Teterivka amalgamated community of the amalgamated Zhytomyr district. 36 water samples were selected from the sources of non-centralized water supply. Water quality classes were determined following DSTU (National Standards of Ukraine) 4808:2007 “Sources of Centralized Drinking Water Supply. Hygienic and Environmental Requirements for Water Quality and Selection Rules”. As a result, it has been established that nitrates make the largest contribution to the pollution of drinking water. In 47% of the selected samples, the nitrate content on average exceeded the norm; and in 46.7% of the investigated settlements, water belongs to quality class 4, defined as “mediocre”, “partially potable” of undesirable quality. A critical situation was recorded in the villages of Mykhailivka, Nova Rudnia and Staroshiika, where the nitrate content in all selected samples of the well water exceeded the norm. On average, 61% of the selected water samples did not meet the standard and were below the standard. According to the pH indicator, the quality classes vary from “excellent”, very pure water grading to the class of “good”, pure water of the desired quality to “satisfactory”, slightly contaminated water of acceptable quality. The total iron content exceeded the standard in 5.6% of the selected samples.
Environment and economic development in Iran
Authors:   Amirkabir university of technology (Tehran polytechnic), Norouzi Nima
Published: November 2021

In the early 1970s, Iran showed a strong desire to create a healthy environment. However, no one expected Iran to sacrifice economic growth for the environment. Therefore, the constitution included some principles that combined pollution control and environmental protection programs with current development programs to ensure that environmental activities are considered part of national development. Iran's development programs show that in encouraging and preserving the environment, the role of the government before and after the Islamic Revolution, instead of promoting competition, efficiency, and protection through market mechanisms, was direct command and supervision. In this regard, the weakness of executive programs, lack of public awareness and disregard for individuals and factories of policies and laws, prioritization of annual budget allocation in areas other than the environment has led to the inability of environmental control policies in Iran. Therefore, it is very important to answer two basic questions in the future. Do the beliefs of the people of the society matter for the destruction of the environment and call for serious action to deal with the environmental hazards? Has the government provided a suitable platform and opportunity for environmental protection? Answering these questions leads to the formulation of policies and their operational implementation concerning environmental issues in the country's program and budget, and the success of policies depends on the answers to these questions.
State and quality of water in the Desna river basin (within the Chernigiv region)
Authors:   Odessa State Environmental University, Chugai Angelina , Нlod Anastasiia ,   Odessa State Environmental University, Pylypiuk Victor ,   Odessa State Environmental University
Published: November 2021

The Desna River is a tributary of the Dnieper with a total length of 575 km within Ukraine. 468 km of them flows through the Chernihiv region. The main pollution sources of the water bodies in the Chernihiv region are utilities. Continuous monitoring of the surface water state is relevant and necessary, as it allows to give a reliable water quality assessment, to identify the anthropogenic impact factors and to assess the technogenic loading in order to establish the level of water use and to develop a set of measures to improve the state of water and the environment in general. The materials of monitoring observations of the water quality indicators of the Desna river for a long-term period, as well as the materials of the Ecological passports of the Chernihiv region concerning the water use indicators, were used as the initial data in the work. The analysis of the hydrochemical regime of the Desna River over a long period was performed using a graphical method. The assessment of the technogenic impact on the water bodies of the region was performed using the method of assessing the efficiency of water use based on the water consumption and sewerage efficiency coefficients. The analysis of the content of the water quality indicators showed that constant exceedance of the MPC (Maximum Permissible Concentrations) in the waters of the Desna River within the Chernihiv region was observed in the content of phosphates and nitrites, as well as total iron and manganese. The results of the assessment of the technogenic impact on the water basin of the Desna River showed that the drainage coefficient underwent certain changes with the best indicators in 2015–2016. No sharp fluctuations in the values of the water supply coefficient were observed. The best values of the water use efficiency complex coefficient were noted in 2015–2016. In general, in recent years the efficiency of water using indicators of the Desna River water in the Chernihiv region has corresponded to the average indicators. The results of the assessment of the technogenic impact on all components of the environment in the Chernihiv region showed that in recent years there has been a tendency to reduce the technogenic impact complex indicator. In general, the Chernihiv region can be attributed to the second ecological district with a moderate technogenic loading level.
Household waste management system planning in the Poltava region
Authors:   National University “Yuri Kondratyuk Poltava Polytechnic”, Illiash Oksana , Holik Yuri ,   National University “Yuri Kondratyuk Poltava Polytechnic”, Maksiuta Nataliia ,   National University “Yuri Kondratyuk Poltava Polytechnic”
Published: November 2021

Today in Ukraine, the municipal waste management system is focused on landfill waste, mainly their disposal in landfills and unauthorized dumps, most of which do not meet the requirements of environmental safety. Accordingly, the main task at the state and regional levels is to implement a systematic approach to waste management, which will ensure both a gradual reduction in waste generation and an increase in their processing and reuse. Implementation of this task requires the implementation of a set of measures provided by the National Waste Management Strategy in Ukraine until 2030 (approved by the Cabinet of Ministers of Ukraine dated November 8, 2017, No. 820 (Order of the Cabinet of Ministers of Ukraine 2017, No. 820-r) and the National Waste Management Plan until 2030 (approved by the Cabinet of Ministers of Ukraine on February 20, 2019, No. 117-p (Order of the Cabinet of Ministers of Ukraine 2019, No. 117- r). According to documents, a crucial step for each region of Ukraine is developing a regional waste management plan based on a phase of strategic planning of all processes of waste management. The importance of this stage increases as a result of the completed process of power decentralization in Ukraine, and, accordingly, delegating authority to address most community development issues to the local powers.
İstanbul Kenti Bazı Alışveriş Caddelerinin Peyzaj Tasarımı Açısından Değerlendirilmesi
Authors: ÖZKAN Pınar , SEYİDOĞLU AKDENİZ Nilüfer
Published: November 2021

Türkiye’nin en büyük metropol kenti olan İstanbul’un merkezi konumunda yer alan ve ticari ve sosyo-kültürel anlamda önemli yere sahip olan bazı alışveriş caddelerinin ele alındığı bu çalışmada, İstiklal Caddesi, Nişantaşı Bölgesi Caddeleri (Rumeli Caddesi, Teşvikiye Caddesi, Abdi İpekçi Caddesi, Maçka Caddesi) Bağdat Caddesi, General Asım Gündüz Caddesi, Fevzipaşa Caddesi, Bakırköy Bölgesi Caddeleri (Fahri Korutürk Caddesi, Ebuzziya Caddesi), Marmara Caddesi ve 58. Bulvar Caddesi çalışma materyali olarak belirlenmiştir. Seçilen sekiz caddenin günümüze kadar geçirdiği değişimler ile birlikte yapısal ve bitkisel tasarımı açısından mevcut durum tespiti yapılarak olumsuzluklar belirlenmiş ve öneriler getirilmiştir. Sonuç olarak alışveriş caddelerinin yoğun kullanıma sahip, birçok ulusal ve uluslararası markaların yer aldığı caddeler olmakla birlikte her biri tarihsel süreçte ayrı bir önem taşıdığı ve kentin bağlantı noktaları üzerinde yer aldığı görülmüştür. Alışveriş caddelerine ulaşım sıkıntısının bulunmadığı fakat yoğun kullanıma bağlı olarak otopark sıkıntısının yaşandığı tespit edilmiştir. Caddelerin donatı ve bitkisel elemanlar bakımından tasarım açısından nispeten iyi olmakla birlikte birtakım eksikliklerinin de bulunduğu saptanmıştır. Özellikle İstiklal ve Nişantaşı Bölgesi Caddeleri, dar caddeler olup oturma birimlerinin eksik olduğu tespit edilmiştir. Nişantaşı Bölgesi, Bağdat ve Fevzipaşa Caddeleri’nde ise yaya araç ve trafiğinin birbirinden ayrılması gerekmektedir. Ayrıca bitkisel öğelerin olmadığı caddelerde bitki kullanımı ile tasarımların desteklenmelidir. Caddelerdeki olumsuzlukların giderilmesiyle etkili kullanımın sağlanması yanı sıra bütüncül yaklaşımlar ile tasarımlarının güçlendirilmesi gerekmektedir.
Vaccines for the COVID-19 α Variant: An Econometric Analysis
Authors: McIntosh James
Published: November 2021

This study examines the success of COVID-19 vaccines in four European countries and Israel for the α variant. These countries respond to the vaccines with varying degrees of success. Countries with successful vaccination programs take about 160 days to get to the minimum number of new cases. Only Italy and Israel came close to eradicating the virus. Vaccines and previous infections have a similar prophylactic effect on new infections. Second doses for the most part add little protection to those who have only one dose. Vaccines become very effective after seven days although there are some added benefits that accrue to individuals in the second week after vaccination. The effect of vaccines on new cases is non-linear and exhibits a decreasing marginal effect. COVID-19 is spread by asymptomatic carriers, a feature of the disease which was discernable at the same time that public health agencies were discouraging the use of masks by the general public and downplaying the importance of social distancing. These were major policy errors and led to many unnecessary deaths.
Praktikalitas Modul Asam Basa Berbasis Inkuiri Terbimbing Kelas XI MIPA
Authors: Shafitri Mutia , Iryani Iryani
Published: November 2021

This study aims to determine the practicality of the guided inquiry-based acid-base module in class XI MIPA. This study uses a plomp development model consisting of 3 stages, namely initial research, prototype development, and the assessment stage. The instrument used in the practicality test is in the form of a questionnaire given to teachers and students. The practicality value is calculated by using Aiken V formula. The result of this study indicates that the module developed has a practical value of 0,89 with a high category.
analisis kesalahan shiekibun pada mahasiswa pendidikan bahasa jepang tahun masuk 2017 universitas negeri padang
Authors: Andra Indri Permata , Zalman Hendri
Published: November 2021

Penelitian ini membahas tentang analisis kesalahan shiekiebun mahasiswa tahun masuk 2017 program studi pendidikan bahasa Jepang Universitas Negeri Padang. Tujuan penelitian ini adalah untuk mengetahui bentuk kesalahan, jenis kesalahan, dan penyebab kesalahan penggunaan shiekibun padamahasiswa tahun masuk 2017 program studi pendidikan bahasa Jepang Universitas Negeri Padang. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan metode deskriptif. Populasi dalam penelitian ini adalah mahasiswa tahun masuk 2017 Prodi Pendidikan Bahasa Jepang Universitas Negeri Padang yang berjumlah 56 orang.  Sampel dalam penelitian ini berjumlah 30 orang. Data penelitian ini adalah nilai tes kesalahan shiekiebun mahasiswa tahun masuk 2017 program studi pendidikan bahasa Jepang Universitas Negeri Padang. Berdasarkan hasil penelitian yang dilaksanakan dapat disimpulkan bahwa terdapat bentuk kesalahan morfologi sebesar 40,2%, dan pada bentuk kesalahan sintaksis sebesar 59,8%. Kemudian terdapat jenis kesalahan lapses sebesar 53,8%, dan Mistake sebesar 46,2%. Dan pada penyebab kesalahan yang disebabkan oleh faktor performansi 23,8%, faktor kompetensi sebesar 70,7%, dan faktor generalisasi sebesar 5,5%.Kata kunci: Analisis Kesalahan, shiekiebun
Hybrides Projektmanagement und Selbstorganisation in einer klassisch hierarchischen Organisation. Erläuterung anhand eines Projektes für Dieselgeneratorensysteme
Authors: Talay Markus , Hümmer Matthias
Published: November 2021

Innerhalb der Ausführung eines Großprojektes der Framatome wurde bei einem Systemlieferanten die Lieferung von Dieselgeneratorensysteme beauftragt. Der Auftrag umfasste neben der Hardwarelieferung auch das erforderliche Engineering und die Dokumentation. Dabei war der vertragliche Projektausführungsrahmen (Budget und Zeit) knapp bemessen bei gleichzeitig hohen Anforderungen an die Qualität und vielen Schnittstellen. Es ist nicht verwunderlich, dass die Abwicklung nach klassischen Projektmanagementmethoden (PMM) das Projekt schnell in eine Krise führte. Durch einen Wechsel der PMM hin zu einem agileren Vorgehen mittels hybridem Projektmanagement und Selbstorganisation konnte eine signifikante Verbesserung des Projektergebnisses erzielt werden. Eine vollkommen neue Abwicklungsform, erfolgreich eingesetzt unter den Randbedingungen eines starren und hierarchisch organisierten Unternehmens. Grundvoraussetzung dafür sind Vertrauen, Exzellenz und Rahmenbedingungen (RVE-Konzept).
CLINICAL CASE OG GRANULAR CELL OVARIAN TUMOR
Authors: L. V. Nykyfor  , L. M. Rak  , O. B. Herovsʹka-Kovbasyuk
Published: November 2021

Ivestigation of the diagnostics issues, treatment of granulosa-cell tumors of the ovary (GCTO), especially granulosa-cell tumors of the juvenile type (GCTJT), showed insufficient study of the problem, and many questions are quite contradictory. This is due to their relatively rare occurrence and a small number of analyzed observations, which does not allow us to draw conclusions on the main issues of problems with the required degree of reliability. The articlepresents a clinical case of GCTJT in a girl aged 17 years, which occurred in the practice of the doctors at the gynecological department of a hospital. In the case of ovaries tumor formation presence with a solid and cystic component GCTJT should be suspected. Tumor-like formations of applications with a solid component require the determination of antimulhuric hormone as a marker of GCTO. In case of GCTJT suspicion, it is useful to supplement the diagnostic stage by determining of the  serum inhibin B level as a marker of the disease. The oncomarkers СА-125 and НЕ-4 are not specific markers GCTO. In the case, described below, the level of tumor markers of ovaries of CA-125 and NE4 was in the normal range. At the same time, the level of antimuler hormone, whose value was 15 times higher than the maximal reference value, was more indicative. The main treatment of  GCTO is surgical. The operation allows to obtain the maximum diagnostic information for the planning of the further tactics. Introduction of on-line communication with oncologists in case of suspicion of malignancy of the process, improves the quality of diagnosis and provision of surgical care, since GCTO are rarely encountered in the practice of operating gynecologists and the most important is the intraoperative choice tactics. The familiarization of specialists with the clinical case of granulosic-cell tumor of the juvenile type ovary, described below - took place in our practice and we believe it will be useful to gynecologists.
Alternative ways of the development of babies’ visual perception
Authors: Y. Kovaliova  , O. Solyanyk  , K. Myronenk
Published: November 2021

The article describes the importance of visual perception for newborns` neurobehavioral development. Alternative ways of stimulation of visual analyzer in newborns with diseases of retina or optic nerve are described. The usage of color-therapy for improving of visual perception of babies with central neurological system damage and partial atrophy of optic nerve is presented. Color-therapy can have positive effect on development of newborns` visual perception.
DEVELOPMENT AND IMPLEMENTATION OF A PROGRAM OF PERSONALIZED APPROACH TO THE MANAGEMENT OF PATIENTS WITH CONSTITUTIONAL DELAY OF GROWTH AND PUBERTY
Authors:   Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, Filina N.Yu. , Cherednikova K.A. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, Bolotova N.V. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, Averyanov A.P. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia, Polyakov V.K. ,   Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia
Published: November 2021

Objective of the study: development and implementation of a program of personalized approach to the tactics of managing patients with constitutional delay of growth and puberty (CDGP). Materials and methods of research: a prospective, single-center, randomized study. The article presents the results of a comprehensive examination of 100 adolescent boys, of which the main group (n=70) – boys with CDGP at the age of 14–14.5 years and the comparison group (n=30) – healthy boys of 14–15 years. Clinical (SDS growth, SDS body mass index, orchiometry), laboratory (insulin-like growth factor 1, testosterone, luteinizing hormone, follicle-stimulating hormone, inhibin B, anti-Müllerian hormone, kisspeptin, thyroid stimulating hormone, thyroxin, prolactin), instrumental indicators (bone age, bioimpedansometry), indicators of psychological status (assessment of the quality of life, anxiety level, aggression level, depression level). Statistical processing: Statistica (Version 7 – Index, Stat. Soft Inc., USA) and Microsoft Exel, 2010. The following criteria were used: Mann–Whitney tests, Fisher's exact test, correlation analysis – Spearman® coefficient. In order to develop the algorithm, factor analysis is applied. Results: it was shown that patients with CDGP had a marked lag behind healthy peers in terms of clinical, metabolic and neuroendocrine indicators of physical and sexual development. With the help of factor analysis of the data obtained, a program of a personalized approach to the tactics of managing patients with CDGP has been developed. Various clinical applications of the program are presented. The sensitivity of the proposed method was 74.63%, 95% CI [62.51; 84.47%]; specificity of the method – 93%, 95% CI [77.93; 99.18%]; the accuracy of the diagnostic method – 80.4%, 95% CI [71.11; 87.78%].
CRIMEAN HAEMORRHAGIC FEVER IN A CHILD AFTER A VISIT TO CRIMEA
Authors:   Pirogov Russian National Research Medical University, Moscow, Russia, Sayfullin M.A. ,   National Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Moscow, Russia, Zvereva N.N. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Butenko A.M. ,   National Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Moscow, Russia, Bazarova M.V. ,   Moscow City Infectious Diseases Clinical Hospital No. 1 of the Moscow Department of Healthcare, Moscow, Russia, Dubicheva L.N. ,   Moscow City Infectious Diseases Clinical Hospital No. 1 of the Moscow Department of Healthcare, Moscow, Russia, Karan L.S. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia, Kardonova E.V. ,   Moscow City Infectious Diseases Clinical Hospital No. 1 of the Moscow Department of Healthcare, Moscow, Russia, Larichev V.F. ,   National Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Moscow, Russia, Lopatin A.A. ,   Anti-Plague Center of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia, Mazankova L.N. ,   Russian Medical Academy for Continuous Professional Education, Moscow, Russia, Osmanov I.M. ,   Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia, Samitova E.R. ,   Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia, Smetanina S.V. ,   Moscow City Infectious Diseases Clinical Hospital No. 1 of the Moscow Department of Healthcare, Moscow, Russia
Published: November 2021

This article contains additional information on the features of the clinical picture of Crimean hemorrhagic fever (CHF) in children, the ongoing activity of CHF virus circulation in the territory of the Republic of Crimea, confirms the possibility of imported cases of CHF in non-endemic regions, which is associated with the likely risks of nosocomial and intrafamilial cases of this infection. The data on the course of the disease, clinical and laboratory diagnostic examination of a child infected with CHF in the Crimea are presented.
CLINICAL CASE OF ADVERSE OUTCOME OF NEONATAL LYSTERIOSIS
Authors:   Petrozavodsk State University (PetrSU), Petrozavodsk, Republic of Karelia, Russia, Gumeniuk E.G. , Ukvalberg M.E. ,   Petrozavodsk State University (PetrSU), Petrozavodsk, Republic of Karelia, Russia
Published: November 2021

A clinical case of neonatal listeriosis with an unfavorable outcome is presented. The first symptoms of the disease in a newborn appeared on the 3rd day, intrauterine infection was suspected on the 5th day. A evolving clinical picture with death on day 9 is described. The issues of the ongoing antibiotic therapy are discussed. The diagnosis of neonatal listeriosis was confirmed by the results of postmortem and morphological examination of the deceased newborn. The cause of his death was an early form of listeria infection (septicemia) with damage mainly to the lungs and liver. Specialists who provide care for pregnant women, newborns and children should be alert for listeria infection.
FEATURES OF ULTRASONIC CHARACTERISTICS OF MESENTERIC LYMPH NODES IN COVID-19 IN CHILDREN WITH ACUTE ABDOMINAL SYNDROME: DESCRIPTION OF CLINICAL CASES
Authors:   Petrozavodsk State University (PetrSU), Petrozavodsk, Republic of Karelia, Russia, Nikitin S.S. ,   Children's Republican Hospital of the Republic of Karelia, Petrozavodsk, Republic of Karelia, Russia, Pyattoev Yu.G. ,   Petrozavodsk State University (PetrSU), Petrozavodsk, Republic of Karelia, Russia, Guseva N.B. ,   Pediatric Surgery Department of the Scientific Research Institute for Pediatric Clinical Surgery with the Pirogov Russian National Research Medical University, Moscow, Russia,   G.N. Speransky City Children’s Hospital No. 9, Moscow, Russia,   Scientific and Practical Center for Pediatric Psychoneurology of the Moscow Department of Healthcare, Moscow, Russia, Leukhin M.V. ,   Children's Republican Hospital of the Republic of Karelia, Petrozavodsk, Republic of Karelia, Russia, Vishnevskaya A.V. ,   Children's Republican Hospital of the Republic of Karelia, Petrozavodsk, Republic of Karelia, Russia
Published: November 2021

The authors describe clinical observations of children with acute mesenteric adenitis with PCRconfirmed COVID-19 infection. Attention during ultrasound diagnostics is drawn to the condition of the lymph nodes – mesenteric adenitis in COVID-19 infection was manifested by a significant increase in the size of the nodes – more than 15 mm, a large number of nodes in the cut with a tendency to form a conglomerate, a more rounded shape, significantly increased blood flow, a reaction of the peritoneum in the form its thickening and the presence of free fluid in the abdominal cavity. Unusual for a «ordinary» respiratory viral or intestinal infection type of lymph nodes was the only sign that distinguishes the manifestations of mesenteric infection in COVID-19 infection.
First record of Melanitta fusca in the Republic of Korea and update on Northeast Asian records
Authors:   Laboratory of Animal Behaviour and Conservation, College of Biology and the Environment, Nanjing Forestry University, Borzée Amaël , Moores Nial ,   Birds Korea
Published: November 2021

We report the first confirmed sighting of the globally Vulnerable Melanitta fusca (Anatidae, Anseriformes) from Yeongil Bay in Pohang in the Republic of Korea. Based on the review of the literature and published checklists of two separate databases (Birds Korea and eBird), we consider this to be the first record of M. fusca on the Korean Peninsula and only the third or fourth record of this species in coastal East Asia.
Research progress on the role of sialic acid-binding immunoglobulin-like lectin 9 in various diseases
Authors: Cao Ling , Yuan Xiaoliang
Published: November 2021

Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a receptor that expresses on the surface of immune cells. It plays an important role in the body’s immune response. Increased expression of Siglec-9 has been reported in infectious diseases, autoimmune diseases and cancer. Pathogenic microorganism and tumor cells can inhibit the recognition and killing of immune cells by upregulating their own specific sialic acid and binding with Siglec-9 on the surface of host immune cells, and suppress the release of pro-inflammatory cytokines and promote the release of anti-inflammatory cytokines, eventually leading to immunosuppression, tumor immune escape and the like. However, the immunosuppressive function of Siglec-9 may be advantageous for diseases such as neutrophil asthma and autoimmune diseases. Therefore, further research on the mechanism of action of Siglec-9 is of great significance.
Allogeneic bone marrow transplantation possibly induces a localized type of porokeratosis
Authors: Yamashita Tatsuya , Ohtani Toshio
Published: November 2021

A 15-year-old girl underwent allogenic bone marrow transplantation for neuroblastoma. A few years later, she noticed a round lesion on her left buttock. Since the lesion had been asymptomatic and never grown, more than 20 years had passed before she saw a local doctor to consult about it. Although the lesion was suspected to be tinea corporis, no fungi were found on microscopic examination. Subsequently, administered topical corticosteroids were not effective. She was referred to our hospital for further evaluation, and a skin biopsy confirmed the diagnosis of porokeratosis. There was a possibility that chemotherapy, total body radiation, or immunosuppressive therapy associated with allogeneic bone marrow transplantation was involved in the development of porokeratosis. Numerous cases of acquired porokeratosis in immunocompromised status have been observed; as for those after allogenic bone marrow transplantation, 12 cases have been reported in the English literature, 4 of which had only one or a few lesions on a limited area of body surface. Our case was relatively uncommon in that the lesion was solitary and comparatively large. In a localized type of porokeratosis, it was suggested that a malignant skin tumor developed earlier than in other types. Careful follow-up for malignant transformation is especially required.
Family and Non-Family Businesses in Iran: Coupling among Innovation, Internationalization and Growth-Expectation
Authors: Samsami Mahsa , Schøtt Thomas
Published: November 2021

Gallo and Sveen, in 1991, specified problems of whether family businesses can take advantage of factors facilitating internationalization. We compare family and non-family businesses in innovation, export, and growth-expectation, and consider how outcomes are aligned, with a coupling that may be loose, with a synergy that benefits the business. This raises a further issue, is governance of a business affecting not only each of the outcomes but also their coupling. A representative sample of 530 Iranian businesses was surveyed in 2018 for Global Entrepreneurship Monitor. Innovation, export, and growth-expectation are found to be lower in family businesses. Coupling between innovation and export, and also between export and growth-expectation, are found to be looser in family businesses. - Findings suggest that coupling among performance outcomes in family businesses can feasibly be tightened, thereby reinforcing performance. The findings contribute to understanding the performance endeavors of family businesses as problematized by Gallo and Sveen.