bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanisms Explaining the Longitudinal Effect of Psychosocial Safety Climate on Work Engagement and Emotional Exhaustion among Education and Healthcare Professionals during the COVID-19 Pandemic
Authors: Bourgoin Boucher Kelly , Ivers Hans , Biron Caroline
Published: June 2024

During the COVID-19 pandemic, the education and healthcare sectors were severely affected. There is a need to investigate the ways in which these workers in at-risk sectors can be protected and through what mechanisms. The aims of this research are, therefore, (1) to assess the mediating role of job demands and resources in the relationship between psychosocial safety climate (PSC) and work engagement and emotional exhaustion, and (2) to test for sector-specific differences among education and healthcare professionals during the COVID-19 pandemic. In the study, which employed a longitudinal design including three measurement times, 70 education professionals and 69 healthcare professionals completed a questionnaire measuring PSC, psychological demands, social support, recognition, work engagement, and emotional exhaustion. The results show that PSC was significantly higher among education professionals than among healthcare professionals. When considering both job sectors together, mediation analyses show that social support mediates the PSC–work engagement relationship, while psychological demands mediate the PSC–emotional exhaustion relationship. Moderated mediation analyses show that job sector is a moderator: among education professionals, colleague support and recognition mediate the PSC–work engagement relationship, and psychological demands mediate the PSC–emotional exhaustion relationship. PSC is associated with more balanced job demands and resources, higher work engagement, and lower emotional exhaustion among education and healthcare professionals. The study of these two sectors, which are both vital to society but also more exposed to adverse work conditions, shows the importance that managers and executives must attach to their mental health by improving their respective working conditions.
“You Aren’t Alone”: An Analysis of Trans Latinas’ Use of Instagram
Authors: Alvarez-Hernandez Luis R. , Lough Kyser , Estevez Rebekah
Published: June 2024

Social media platforms, such as Instagram, provide space for marginalized groups to connect, learn about and express themselves, and cultivate community. Trans Latinas, a group target of violence and discrimination, resist by expressing themselves and building community through social media. As cisgender researchers, we explored how trans Latinas use #translatina on Instagram as a shared space to present themselves and their identities, to leverage this knowledge in our fields. We analyzed 134 posts in February and March of 2020 employing basic and interpretive content analyses while considering Goffman’s theory of presentation of self. Results showed that trans Latinas mostly presented individually through posed selfies taken near the camera, using a straight camera angle, standing, not smiling, and making eye contact. Most users wore makeup, styled hair, and accessories. Analyzing written captions and photos, four themes were constructed to understand how trans Latinas presented their identities and connected with others: (1) expressions of beauty and femininity, (2) fostering community, (3) commercial or work, and (4) feeling good and confident. These results have implications for mental health and health promotion practices, as social media could serve as affirming spaces for trans Latinas to reinforce their self-determination, maintain a sense of self, and build community.
Meta-Analysis of Internet Gaming Disorder Prevalence: Assessing the Impacts of DSM-5 and ICD-11 Diagnostic Criteria
Authors: Zhou Ruoyu , Morita Nobuaki , Ogai Yasukazu , Saito Tamaki , Zhang Xinyue , Yang Wenjie , Yang Fan
Published: June 2024

With the inclusion of Internet gaming disorder (IGD) in both the DSM-5 and ICD-11, understanding the prevalence and diagnostic discrepancies is crucial for developing appropriate interventions. This study presents a meta-analysis of the prevalence of IGD based on two diagnostic criteria. We systematically searched the PubMed and Web of Science databases. A total of 22 studies were included in the final analysis. The analysis incorporated studies employing the DSM-5 and ICD-11 criteria and focused on the impact of various factors, including study location, sample characteristics, sample size, and quality score, on the reported prevalence rates using a random-effects model. The pooled prevalence of IGD is 6.7% (95% CI: 5.7–7.7%). The subgroup analysis indicated significant differences in the prevalence rates of IGD (DSM-5 criteria) and GD (ICD-11 criteria) (Q b = 38.46, p < 0.01). There were also significant differences in IGD prevalence rates between different scales (Q b = 54.23, p < 0.001). Our findings indicate that different diagnostic criteria and different assessment scales have a significant impact on the prevalence of IGD. This underscores the importance of adopting standardized methodologies to guide public health interventions. However, given the limited research based on ICD-11 diagnostic criteria, further investigation is necessary to determine the variations in prevalence rates of IGD under different diagnostic standards.
When You Think of and Identify Yourself as a Nurse, You Will Become More Deontological and Less Utilitarian
Authors: Zheng Mufan , Zhao Junhua , Zhang Xielan
Published: June 2024

This study aims to examine how the activation of the role of nursee and professional identification as a nurse can influence moral judgments in terms of deontological and utilitarian inclinations. In Study 1, a priming technique was used to assess the impact of activating the nursing concept on moral reasoning. Participants were randomly assigned to either a nursing prime or neutral prime condition. By using a scrambled-sentence task, participants were prompted to think about nursing-related or neutral thoughts. Following the priming task, participants were asked to respond to 20 moral dilemmas. The process dissociation approach was employed to measure the degree of deontological and utilitarian tendencies in their moral reasoning. In Study 2, participants completed the nursing profession identification scale and the moral orientation scale before engaging in moral judgments similar to those in Study 1. The findings revealed that priming the concept of being a nursee resulted in an increase in deontological clinical inclinations while having no significant effect on utilitarian inclinations. Additionally, a positive correlation was observed between identification with the nursing profession and deontological clinical inclinations, whereas a negative correlation was found with utilitarian inclinations. Deliberation orientation acted as a complete mediator in the relationship between nursing professional identification and deontological tendencies and as a partial mediator for utilitarian tendencies.
Charting a Path to the Quintuple Aim: Harnessing AI to Address Social Determinants of Health
Authors: Shah Yash B. , Goldberg Zachary N. , Harness Erika D. , Nash David B.
Published: June 2024

The Quintuple Aim seeks to improve healthcare by addressing social determinants of health (SDOHs), which are responsible for 70–80% of medical outcomes. SDOH-related concerns have traditionally been addressed through referrals to social workers and community-based organizations (CBOs), but these pathways have had limited success in connecting patients with resources. Given that health inequity is expected to cost the United States nearly USD 300 billion by 2050, new artificial intelligence (AI) technology may aid providers in addressing SDOH. In this commentary, we present our experience with using ChatGPT to obtain SDOH management recommendations for archetypal patients in Philadelphia, PA. ChatGPT identified relevant SDOH resources and provided contact information for local organizations. Future exploration could improve AI prompts and integrate AI into electronic medical records to provide healthcare providers with real-time SDOH recommendations during appointments.
Cardiorespiratory Performance, Physical Activity, and Depression in Thai Older Adults with Sarcopenia and No Sarcopenia: A Matched Case-Control Study
Authors: Boontanom Nuntiya , Kooncumchoo Patcharee , Yuenyongchaiwat Kornanong
Published: June 2024

Background: Older adults have a high risk for musculoskeletal, cardiorespiratory, and mental health problems. We compared respiratory muscle strength, cardiovascular endurance, physical activity (PA), and depression between older adults with and without sarcopenia. Methods: This matched case–control study included 200 Thai older adults (100 participants with and without sarcopenia). According to the Asian Working Group for Sarcopenia 2019, participants completed a handgrip dynamometer, a 6 m walk test, and bioimpedance analysis for sarcopenia screening. Individuals were required to evaluate their cardiovascular endurance and respiratory muscle strength and complete a set of questionnaires (i.e., depression and PA). Participants with and without sarcopenia were compared using a t-test, and ANOVA was used for subgroup analysis. Results: Participants with sarcopenia had significantly lower inspiratory muscle strength (p < 0.001), functional capacity (p = 0.032), PA (p < 0.001), and higher depression scores (p < 0.001) than those without sarcopenia. Respiratory muscle strength and PA were significantly reduced in those with severe sarcopenia, followed by those with sarcopenia, possible sarcopenia, and no sarcopenia. Older adults with severe sarcopenia had higher depression scores than those with sarcopenia, possible sarcopenia, or no sarcopenia. Conclusions: Older adults with sarcopenia may exhibit lower cardiorespiratory performance, less PA, and higher depression than those without sarcopenia.
Interpretation of Hot Spots in Wuhan New Town Development and Analysis of Influencing Factors Based on Spatio-Temporal Pattern Mining
Authors: Zhao Haijuan , Long Yan , Wang Nina , Luo Shiqi , Liu Xi , Luo Tianyue , Wang Guoen , Liu Xuejun
Published: June 2024

The construction of new towns is one of the main measures to evacuate urban populations and promote regional coordination and urban–rural integration in China. Mining the spatio-temporal pattern of new town hot spots based on multivariate data and analyzing the influencing factors of new town construction hot spots can provide a strategic basis for new town construction, but few researchers have extracted and analyzed the influencing factors of new town internal hot spots and their classification. In order to define the key points of Wuhan’s new town construction and promote the construction of new cities in an orderly and efficient manner, this paper first constructs a space-time cube based on the luminous remote sensing data from 2010 to 2019, extracts hot spots and emerging hot spots in Wuhan New City, selects 14 influencing factor indicators such as population density, and uses bivariate Moran’s index to analyze the influencing factors of hot spots, indicating that the number of bus stops and vegetation coverage rate are the most significant. Secondly, the disorderly multivariate logistic regression model is used to analyze the influencing factors of emerging hot spots. The results show that population density, vegetation coverage, road density, distance to water bodies, and distance to train stations are the most significant factors. Finally, based on the analysis results, some relevant suggestions for the construction of Wuhan New City are proposed, providing theoretical support for the planning and policy guidance of new cities, and offering reference for the construction of new towns in other cities, promoting the construction of high-quality cities.
Simplifying Land Cover-Geoprocessing-Model Migration with a PAMC-LC Containerization Strategy in the Open Web Environment
Authors: Xing Huaqiao , Wang Haihang , Gao Denghai , Hou Dongyang , Wu Huayi
Published: June 2024

Land cover and its changes over time are significant for better understanding the Earth’s fundamental characteristics and processes, such as global climate change, hydrology, and the carbon cycle. A number of land cover-geoprocessing models have been proposed for land cover-data production with different spatial and temporal resolutions. With the massive growth in land cover data and the increasing demand for efficient model utilization, developing efficient and convenient land cover-geoprocessing models has become a formidable challenge. Although some model-migration methods have been proposed for handling the massive data, the intricacy of land cover-data and -heterogeneity models frequently prevent current strategies from directly meeting demand. In this paper, we propose the PAMC-LC-containerization approach to overcome the difficulties associated with moving existing land cover models in the open web environment. Based on the idea of model migration, we design a standardized model description and hierarchical encapsulation strategy for land cover models, and develop migration and deployment methods. Furthermore, we assess the viability and efficacy of the proposed approach by using coupled workflows for model migration and the introduction of visualization on the Mts-WH dataset and the Google dataset. The experimental results show that the PAMC-LC approach can simplify and streamline the model migration process, with important ramifications for increasing productivity, reusing models, and lowering additional data-transmission costs.
On the Cholesterol Raising Effect of Coffee Diterpenes Cafestol and 16-O-Methylcafestol: Interaction with Farnesoid X Receptor
Authors: Guercia Elena , Berti Federico , De Zorzi Rita , Navarini Luciano , Geremia Silvano , Medagli Barbara , De Conto Marco , Cassetta Alberto , Forzato Cristina
Published: June 2024

The diterpene cafestol represents the most potent cholesterol-elevating compound known in the human diet, being responsible for more than 80% of the effect of coffee on serum lipids, with a mechanism still not fully clarified. In the present study, the interaction of cafestol and 16-O-methylcafestol with the stabilized ligand-binding domain (LBD) of the Farnesoid X Receptor was evaluated by fluorescence and circular dichroism. Fluorescence quenching was observed with both cafestol and 16-O-methylcafestol due to an interaction occurring in the close environment of the tryptophan W454 residue of the protein, as confirmed by docking and molecular dynamics. A conformational change of the protein was also observed by circular dichroism, particularly for cafestol. These results provide evidence at the molecular level of the interactions of FXR with the coffee diterpenes, confirming that cafestol can act as an agonist of FXR, causing an enhancement of the cholesterol level in blood serum.
Gas Chromatography–Mass Spectrometry Metabolite Analysis Combined with Transcriptomics Reveals Genes Involved in Wax Biosynthesis in Allium fistulosum L.
Authors: Xing Jiayi , Xu Huanhuan , Zhu Mingzhao , Zhang Yuchen , Bai Mifeng , Zhou Xuyang , Liu Huiying , Wang Yongqin
Published: June 2024

Cuticular waxes are essential for protecting plants from various environmental stresses. Allium fistulosum serves as an excellent model for investigating the regulatory mechanisms underlying cuticular wax synthesis with notable epidermal wax characteristics. A combination of gas chromatography–mass spectrometry (GC–MS) metabolite analysis and transcriptomics was used to investigate variations in metabolites and gene expression patterns between the wild type (WT) and glossy mutant type (gl2) of A. fistulosum. The WT surface had a large number of acicular and lamellar waxy crystals, whereas the leaf surface of gl2 was essentially devoid of waxy crystals. And the results revealed a significant decrease in the content of 16-hentriacontanone, the principal component of cuticular wax, in the gl2 mutant. Transcriptomic analysis revealed 3084 differentially expressed genes (DEGs) between WT and gl2. Moreover, we identified 12 genes related to fatty acid or wax synthesis. Among these, 10 DEGs were associated with positive regulation of wax synthesis, whereas 2 genes exhibited negative regulatory functions. Furthermore, two of these genes were identified as key regulators through weighted gene co-expression network analysis. Notably, the promoter region of AfisC5G01838 (AfCER1-LIKE1) exhibited a 258-bp insertion upstream of the coding region in gl2 and decreased the transcription of the AfCER1-LIKE1 gene. This study provided insights into the molecular mechanisms governing cuticular wax synthesis in A. fistulosum, laying the foundation for future breeding strategies.
Unraveling the Role of Reactive Oxygen Species in T Lymphocyte Signaling
Authors: Gülow Karsten , Tümen Deniz , Heumann Philipp , Schmid Stephan , Kandulski Arne , Müller Martina , Kunst Claudia
Published: June 2024

Reactive oxygen species (ROS) are central to inter- and intracellular signaling. Their localized and transient effects are due to their short half-life, especially when generated in controlled amounts. Upon T cell receptor (TCR) activation, regulated ROS signaling is primarily initiated by complexes I and III of the electron transport chain (ETC). Subsequent ROS production triggers the activation of nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH oxidase 2), prolonging the oxidative signal. This signal then engages kinase signaling cascades such as the mitogen-activated protein kinase (MAPK) pathway and increases the activity of REDOX-sensitive transcription factors such as nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1). To limit ROS overproduction and prevent oxidative stress, nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant proteins such as superoxide dismutases (SODs) finely regulate signal intensity and are capable of terminating the oxidative signal when needed. Thus, oxidative signals, such as T cell activation, are well-controlled and critical for cellular communication.
Extracellular Vesicles in Diabetic Cardiomyopathy—State of the Art and Future Perspectives
Authors: Zygmunciak Przemysław , Stróżna Katarzyna , Błażowska Olga , Mrozikiewicz-Rakowska Beata
Published: June 2024

Cardiovascular complications are the most deadly and cost-driving effects of diabetes mellitus (DM). One of them, which is steadily attracting attention among scientists, is diabetes-induced heart failure, also known as diabetic cardiomyopathy (DCM). Despite significant progress in the research concerning the disease, a universally accepted definition is still lacking. The pathophysiology of the processes accelerating heart insufficiency in diabetic patients on molecular and cellular levels also remains elusive. However, the recent interest concerning extracellular vesicles (EVs) has brought promise to further clarifying the pathological events that lead to DCM. In this review, we sum up recent investigations on the involvement of EVs in DCM and show their therapeutic and indicatory potential.
Genome-Wide Transcriptomic and Metabolomic Analyses Unveiling the Defence Mechanisms of Populus tremula against Sucking and Chewing Insect Herbivores
Authors: Pastierovič Filip , Mogilicherla Kanakachari , Hradecký Jaromír , Kalyniukova Alina , Dvořák Ondřej , Roy Amit , Tomášková Ivana
Published: June 2024

Plants and insects coevolved as an evolutionarily successful and enduring association. The molecular arms race led to evolutionary novelties regarding unique mechanisms of defence and detoxification in plants and insects. While insects adopt mechanisms to conquer host defence, trees develop well-orchestrated and species-specific defence strategies against insect herbivory. However, current knowledge on the molecular underpinnings of fine-tuned tree defence responses against different herbivore insects is still restricted. In the current study, using a multi-omics approach, we unveiled the defence response of Populus tremula against aphids (Chaitophorus populialbae) and spongy moths (Lymantria dispar) herbivory. Comparative differential gene expression (DGE) analyses revealed that around 272 and 1203 transcripts were differentially regulated in P. tremula after moth and aphid herbivory compared to uninfested controls. Interestingly, 5716 transcripts were differentially regulated in P. tremula between aphids and moth infestation. Further investigation showed that defence-related stress hormones and their lipid precursors, transcription factors, and signalling molecules were over-expressed, whereas the growth-related counterparts were suppressed in P. tremula after aphid and moth herbivory. Metabolomics analysis documented that around 37% of all significantly abundant metabolites were associated with biochemical pathways related to tree growth and defence. However, the metabolic profiles of aphid and moth-fed trees were quite distinct, indicating species-specific response optimization. After identifying the suitable reference genes in P. tremula, the omics data were further validated using RT-qPCR. Nevertheless, our findings documented species-specific fine-tuning of the defence response of P. tremula, showing conservation on resource allocation for defence overgrowth under aphid and moth herbivory. Such findings can be exploited to enhance our current understanding of molecular orchestration of tree responses against herbivory and aid in developing insect pest resistance P. tremula varieties.
Integrative Metabolomics, Enzymatic Activity, and Gene Expression Analysis Provide Insights into the Metabolic Profile Differences between the Slow-Twitch Muscle and Fast-Twitch Muscle of Pseudocaranx dentex
Authors: Wang Huan , Li Busu , Li Ang , An Changting , Liu Shufang , Zhuang Zhimeng
Published: June 2024

The skeletal muscles of teleost fish encompass heterogeneous muscle types, termed slow-twitch muscle (SM) and fast-twitch muscle (FM), characterized by distinct morphological, anatomical, histological, biochemical, and physiological attributes, driving different swimming behaviors. Despite the central role of metabolism in regulating skeletal muscle types and functions, comprehensive metabolomics investigations focusing on the metabolic differences between these muscle types are lacking. To reveal the differences in metabolic characteristics between the SM and FM of teleost, we conducted an untargeted metabolomics analysis using Pseudocaranx dentex as a representative model and identified 411 differential metabolites (DFMs), of which 345 exhibited higher contents in SM and 66 in FM. KEGG enrichment analysis showed that these DFMs were enriched in the metabolic processes of lipids, amino acids, carbohydrates, purines, and vitamins, suggesting that there were significant differences between the SM and FM in multiple metabolic pathways, especially in the metabolism of energy substances. Furthermore, an integrative analysis of metabolite contents, enzymatic activity assays, and gene expression levels involved in ATP-PCr phosphate, anaerobic glycolysis, and aerobic oxidative energy systems was performed to explore the potential regulatory mechanisms of energy metabolism differences. The results unveiled a set of differential metabolites, enzymes, and genes between the SM and FM, providing compelling molecular evidence of the FM achieving a higher anaerobic energy supply capacity through the ATP-PCr phosphate and glycolysis energy systems, while the SM obtains greater energy supply capacity via aerobic oxidation. These findings significantly advance our understanding of the metabolic profiles and related regulatory mechanisms of skeletal muscles, thereby expanding the knowledge of metabolic physiology and ecological adaptation in teleost fish.
Lead Decreases Bone Morphogenetic Protein-7 (BMP-7) Expression and Increases Renal Cell Carcinoma Growth in a Sex-Divergent Manner
Authors: Grunz Elizabeth A. , Anderson Haley , Ernst Rebecka M. , Price Spencer , Good D’Artanyan , Vieira-Potter Victoria , Parrish Alan R.
Published: June 2024

Both tissue and blood lead levels are elevated in renal cell carcinoma (RCC) patients. These studies assessed the impact of the subchronic lead challenge on the progression of RCC in vitro and in vivo. Lead challenge of Renca cells with 0.5 μM lead acetate for 10 consecutive passages decreased E-cadherin expression and cell aggregation. Proliferation, colony formation, and wound healing were increased. When lead-challenged cells were injected into mice, tumor size at day 21 was increased; interestingly, this increase was seen in male but not female mice. When mice were challenged with 32 ppm lead in drinking water for 20 weeks prior to tumor cell injection, there was an increase in tumor size in male, but not female, mice at day 21. To investigate the mechanism underlying the sex differences, the expression of sex hormone receptors in Renca cells was examined. Control Renca cells expressed estrogen receptor (ER) alpha but not ER beta or androgen receptor (AR), as assessed by qPCR, and the expression of ERα was increased in tumors in both sexes. In tumor samples harvested from lead-challenged cells, both ERα and AR were detected by qPCR, yet there was a significant decrease in AR seen in lead-challenged tumor cells from male mice only. This was paralleled by a plate-based array demonstrating the same sex difference in BMP-7 gene expression, which was also significantly decreased in tumors harvested from male but not female mice; this finding was validated by immunohistochemistry. A similar expression pattern was seen in tumors harvested from the mice challenged with lead in the drinking water. These data suggest that lead promotes RCC progression in a sex-dependent via a mechanism that may involve sex-divergent changes in BMP-7 expression.
The Mechanism of Exogenous Salicylic Acid and 6-Benzylaminopurine Regulating the Elongation of Maize Mesocotyl
Authors: Qi Xue , Zhuang Zelong , Ji Xiangzhuo , Bian Jianwen , Peng Yunling
Published: June 2024

The elongation of the mesocotyl plays an important role in the emergence of maize deep-sowing seeds. This study was designed to explore the function of exogenous salicylic acid (SA) and 6-benzylaminopurine (6-BA) in the growth of the maize mesocotyl and to examine its regulatory network. The results showed that the addition of 0.25 mmol/L exogenous SA promoted the elongation of maize mesocotyls under both 3 cm and 15 cm deep-sowing conditions. Conversely, the addition of 10 mg/L exogenous 6-BA inhibited the elongation of maize mesocotyls. Interestingly, the combined treatment of exogenous SA–6-BA also inhibited the elongation of maize mesocotyls. The longitudinal elongation of mesocotyl cells was the main reason affecting the elongation of maize mesocotyls. Transcriptome analysis showed that exogenous SA and 6-BA may interact in the hormone signaling regulatory network of mesocotyl elongation. The differential expression of genes related to auxin (IAA), jasmonic acid (JA), brassinosteroid (BR), cytokinin (CTK) and SA signaling pathways may be related to the regulation of exogenous SA and 6-BA on the growth of mesocotyls. In addition, five candidate genes that may regulate the length of mesocotyls were screened by Weighted Gene Co-Expression Network Analysis (WGCNA). These genes may be involved in the growth of maize mesocotyls through auxin-activated signaling pathways, transmembrane transport, methylation and redox processes. The results enhance our understanding of the plant hormone regulation of mesocotyl growth, which will help to further explore and identify the key genes affecting mesocotyl growth in plant hormone signaling regulatory networks.
Catch of Reesa vespulae in Heritage Environments
Authors: Brimblecombe Peter , Querner Pascal
Published: June 2024

The skin beetle Reesa vespulae is regularly found beyond North America where it originated. The larvae cause considerable concern in museums, as they damage hides or furs in addition to being a special source of damage to collections of dried plants in herbaria or collections of insects and other zoological specimens. Reesa vespulae arrived in Europe in the mid-20th century and was associated mostly with stored food products, but over time, it has become recognised as a museum pest. Although it is still uncommon and may only be observed in a small fraction of museums, when the insect is found in large numbers, it can cause problems. Catches from blunder traps in Austrian museums and from an online database in the UK were used to track changing concern over the insect. As a single female beetle can continue to reproduce because the species is parthenogenetic, its presence can persist over long periods of time. Although small populations in museums are typically found in the adult form, the larval forms are more common where a site is infested by high numbers, perhaps because the larvae and adults must range more widely for food. Although R. vespulae can be controlled using pesticides, it is also possible to kill the larvae within infested materials through freezing or anoxia.
Cognitive Impairments in Parkinson’s Disease: Professional Support and Unmet Rehabilitation Needs in Patients with and without Self-Reported Cognitive Impairments—A Secondary Analysis
Authors: Thuesen Jette , Mikkelsen Tina Broby , Juel Knud , Backmann Tina , Winge Kristian , Wæhrens Eva Ejlersen
Published: June 2024

Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s disease. Cognitive impairments are frequent non-motor symptoms in PD and have a significant impact on everyday life and well-being. Still, rehabilitation services for people with PD predominantly target motor symptoms. Drawing on data from a national Danish survey, this study aimed to determine significant differences among people living with PD with or without perceived cognitive impairments regarding (1) contact with different healthcare professionals, and (2) unmet needs for rehabilitation services. Data were analyzed based on whether the person with PD perceived cognitive impairments or not. Statistically significant differences between results for PD patients with and without cognitive impairments were calculated. Data on 6711 individuals with PD were included in the study. Respondents’ mean age was 73.5 years, and 31% of them were experiencing cognitive impairments. Significantly more people with PD and cognitive impairments were in contact with almost all professionals compared to those without cognitive impairments. However, individuals experiencing cognitive impairments were less often in contact with the professions most experienced in cognitive rehabilitation.
Translation, Cultural Adaptation, and Validation into Romanian of the Myeloproliferative Neoplasm Symptom Assessment Form—Total Symptom Score (MPN-SAF TSS or MPN-10) Questionnaire
Authors: Găman Mihnea-Alexandru , Scherber Robyn Marie , Ursuleac Iulia , Crişan Ana Manuela , Bădeliţă Sorina Nicoleta , Ionescu Bogdan Octavian , Ghiaur Alexandra Elena , Brînză Melen , Pîrciulescu Nicoleta , Lascăr Toma Octavian , Diaconu Camelia Cristina , Găman Amelia Maria , Coriu Daniel
Published: June 2024

Background: Patients with myeloproliferative neoplasms (MPNs) experience a high disease-related symptom burden. A specific instrument to evaluate quality of life (QoL), i.e., the MPN Symptom Assessment Form Total Symptom Score (MPN-SAF TSS; MPN-10), was developed. We conducted the translation, cultural adaptation, and validation into Romanian of the MPN-10. Methods: We translated the MPN-10 and tested its psychometric properties. Results: We recruited 180 MPN patients: 66 polycythemia vera (36.67%), 61 essential thrombocythemia (33.89%), 51 primary and secondary myelofibrosis (SMF) (28.33%), and 2 MPN-unclassifiable (1.11%). The mean TSS was 19.51 ± 16.51 points. Fatigue, inactivity, and concentration problems were the most cumbersome symptoms. We detected scoring differences between MPN subtypes regarding weight loss (p < 0.001), fatigue (p = 0.006), early satiety (p = 0.007), night sweats (p = 0.047), pruritus (p = 0.05), and TSS (p = 0.021). There were strong positive associations between TSS and inactivity, fatigue, and concentration problems, and moderate negative correlations between QoL scores and all MPN-10 items. Cronbach’s α internal consistency coefficient was 0.855. The Kaiser–Meyer–Olkin construct validity test result was 0.870 and the Bartlett Sphericity Test was significant (p < 0.001). Symptom scores were loaded into one single factor according to the exploratory factor analysis. Conclusions: The Romanian MPN-10 version displayed excellent psychometric properties and is a reliable instrument for assessing symptom burden and QoL in Romanian MPN patients.
Highly Porous Titanium Cups Frequently Presenting with Radiolucent Lines in Cementless Primary Total Hip Arthroplasty: A Retrospective Cohort Study
Authors: Ohta Yoichi , Sugama Ryo , Minoda Yukihide , Mizokawa Shigekazu , Takahashi Shinji , Ikebuchi Mitsuhiko , Nakatsuchi Tamotsu , Nakamura Hiroaki
Published: June 2024

Background/Objectives: A highly porous titanium cup with a three-dimensional metal interface was recently introduced to improve biological fixation and survival. However, radiography has revealed concerns regarding these cups, despite their excellent short- and mid-term clinical outcomes. This study compared the clinical and radiographic results of a highly porous titanium cup with those of a hydroxyapatite-coated porous titanium cup after primary total hip arthroplasty (THA). Methods: Fifty-one primary THAs were investigated. A highly porous titanium cup was used in 17 hips, and a hydroxyapatite-coated porous titanium cup was used in 34 hips. No significant differences in preoperative patient demographic characteristics were observed between the two groups. The 2-year postoperative clinical and radiographic results were compared. Results: Radiolucent lines were observed in 13 (76%) of 17 hips with highly porous titanium cups and in none (0%) of 34 hips with hydroxyapatite-coated porous titanium cups (p < 0.001). In the highly porous titanium cup group, radiolucent lines were observed in five hips (29%) in one zone, two hips (11%) in two zones, and six hips (35%) in three zones. No cup loosening was observed in either group. Conclusions: Radiolucent lines were significantly more frequent in highly porous titanium cups. This study suggests that, compared to the three-dimensional structure of porous titanium, the hydroxyapatite coating of porous titanium had a greater influence on bone ingrowth in the short term. The meaning of these findings in the long-term is unclear yet.
Significance of Selected Posturographic Methods in Diagnosis of Balance Disorders in Patients with Early-Stage Gonarthrosis
Authors: Kostro Amanda Maria , Augustynik Artur , Kuryliszyn-Moskal Anna , Jamiołkowski Jacek , Pocienè Monika , Dzięcioł-Anikiej Zofia
Published: June 2024

Degenerative joint disease is a dynamic pathological process characterised by a destabilisation of the degradation and synthesis processes of articular cartilage and subchondral bone layer. Studies suggest that individuals with gonarthrosis experience deficits in proprioception, in addition to changes within their joints, which directly affects their ability to maintain posture and increases their risk of falling. Objectives: The aim of this study was to assess the functional status of patients with gonarthrosis through a posturographic examination conducted on a stabilometric platform (force plate) and a functional clinical examination. Methods: Participants were divided into two groups—a control group (n = 125) and a study group (n = 125). During the qualification process, subjective and objective examinations were conducted, including a functional assessment by means of such tests as the “Up and Go” Test, Functional Reach Test, Five Time Sit to Stand Test, and the Step Test. Subsequently, an assessment was conducted on the force plate by means of a posturographic test—the Romberg test performed with open and closed eyes in a standing position—and balance was evaluated using the Berg Balance Scale. The obtained data were analysed with the use of the IBM SPSS Statistics software version 27.0, by means of the Mann–Whitney test, and correlations were determined by means of Spearman’s test. A significance level of p = 0.05 was adopted. Results: Statistically significant differences were observed among the assessed groups as a result of both functional and posturographic examinations, along with positive correlations for disease duration, age, and BMI index. Conclusions: Patients with gonarthrosis exhibited disturbances in balance, functionality, and posture compared to healthy individuals in the control group.
Cochlear Implantation: Long-Term Effect of Early Activation on Electrode Impedance
Authors: Alahmadi Asma , Abdelsamad Yassin , Yousef Medhat , Almuhawas Fida , Hafez Ahmed , Alzhrani Farid , Hagr Abdulrahman
Published: June 2024

Objectives: The growing adoption of cochlear implants (CIs) necessitates understanding the factors influencing long-term performance and improved outcomes. This work investigated the long-term effect of early activation of CIs on electrode impedance in a large sample of CI users at different time points. Methods: A retrospective study on 915 ears from CI patients who were implanted between 2015 and 2020. According to their CI audio processor activation time, the patients were categorized into early activation (activated 1 day after surgery, n = 481) and classical activation (activated 4 weeks after surgery, n = 434) groups. Then, the impact of the activation times on the electrode impedance values, along the electrode array contacts, at different time points up to two years was studied and analyzed. Results: The early activation group demonstrated lower impedance values across all the electrode array sections compared to the classical activation at 1 month, 1 year, and 2 years post-implantation. At 1 month, early activation was associated with a reduction of 0.34 kΩ, 0.46 kΩ, and 0.37 kΩ in the apical, middle, and basal sections, respectively. These differences persisted at subsequent intervals. Conclusions: Early activation leads to sustained reductions in the electrode impedance compared to classical activation (CA), suggesting that earlier activation might positively affect long-term CI outcomes.
Relationship between Simulated Fire Suppression Activities and Acute Cardiac and Respiratory Events in Firefighters
Authors: Kollock Roger O. , Hale William D. , Fulk Maddie , Seidner Maddie , Szabo Zora , Sanders Gabriel J. , Peveler Will
Published: June 2024

Cardiac deaths account for the largest share of on-duty firefighter deaths. To help ensure duty fitness and minimize injury risk, many fire departments require the passing of an annual physical ability test, consisting of a battery of simulated fire suppression activities (sFSAs). The purpose of the study was to determine the relationship of sFSA performance to acute cardiac and respiratory events (ACREs) and the effect that estimated VO2max has on sFSA performance. The study was retrospective. As part of an annual physical ability test, five timed sFSAs were performed, summed for a composite time, and categorized into three performance levels (fast, moderate, and slow). Estimated VO2max was determined using the Forestry Step Test. A significant (p = 0.023) linear trend was observed with higher sFSA performance times being associated with a higher proportion of firefighters going on to suffer an ACRE. The estimated VO2max was significantly (p < 0.001) higher in the fast group compared to the slow group. There was not a significant (p = 0.70) difference in estimated VO2max between the moderate and slow groups. Estimated VO2max performance and sFSA performance were significantly correlated, with rs(488) = −0.272 and p < 0.001. Poorer sFSA performance was found to be associated with a higher proportion of ACREs. The results suggest that sFSA performance may be a valid indicator of ACRE injury risk and aerobic capacity.
A Method for Full-Depth Sound Speed Profile Reconstruction Based on Average Sound Speed Extrapolation
Authors: Zhang Wei , Jin Shaohua , Bian Gang , Peng Chengyang , Xia Haixing
Published: June 2024

The speed of sound in seawater plays a crucial role in determining the accuracy of multibeam bathymetric measurements. In deep-sea multibeam measurements, the challenge of inadequate longitudinal coverage of sound speed profiles arises from variations in seafloor topography, meteorological conditions, measurement equipment, and operational efficiency, resulting in diminished measurement precision. Building upon the EOF (Empirical Orthogonal Function), a method employed to analyze spatiotemporal data such as sound speeds, this paper addresses the limitations of the EOF method caused by the shallowest sampling depth of the sound speed profile samples. It proposes two methods for EOF reconstruction of measured sound speed profiles extended to full water depth by splicing measured sound speed profiles at non-full water depths with historical average sound speed profiles of the surveyed sea area. Specially, Method 2 introduces the latest metaheuristic optimization algorithm, CPO (Crested Porcupine Optimizer), which exhibited superior performance on multiple standard test functions in 2024. The study reconstructs randomly sampled measured sound speed profiles using the two proposed methods and commonly employed substitution and splicing methods, followed by a comparative analysis of the experimental outcomes. At a sampling depth of 200 m, Method 2 demonstrates performance superior to other methods, with RMSE, MAE, MAPE, and R2 values of 0.9511 m/s, 0.8492 m/s, 0.0566%, and 0.9963, respectively. Method 1 yields corresponding values of 0.9594 m/s, 0.8492 m/s, 0.0568%, and 0.9962, respectively. Despite its slightly inferior performance compared with Method 2, it offers substantial advantages over the substitution and splicing methods. Varying the sampling depth of measured sound speed profiles reveals that Methods 1 and 2 exhibit inferior reconstruction performance in shallow water compared with the substitution and splicing methods. Nevertheless, when the sampling depth surpasses the depth range of initial spatial modes with abrupt variations, both methods achieve notably higher reconstruction accuracy compared with the substitution and splicing methods, reaching a stabilized state. Sound ray tracing reveals that the reconstructed sound speed profiles from both methods meet the stringent accuracy standards for bathymetric measurements, achieving an effective beam ratio of 100%. The proposed methods not only provide rapid reconstruction of sound speed profiles, thereby improving the efficiency of multibeam bathymetric surveys, but also provide references for the reasonable determination of sampling depths of sound speed profiles to ensure reconstruction accuracy, demonstrating practical application value.
Histoplasmosis in Non-HIV Infected Patients: Another Neglected Infection in French Guiana
Authors: Aissaoui Houari , Bourne-Watrin Morgane , Lemarie Benoit , Guillot Genevieve , Aboikoni Alolia , Chhorn Piseth , Gaudard Dana , Hadj-Amara Ghazi , Manasse Ricardo , Ouedraogo Mahamado , Salloum Charles , Demar Magalie , Epelboin Loïc , Kallel Hatem , Adenis Antoine , Nacher Mathieu , Drak Alsibai Kinan , Louvel Dominique
Published: June 2024

(1) Background: Only a few studies on histoplasmosis in immunocompetent patients have been reported in French Guiana. Therefore, we conducted a detailed clinical description of hospitalized patients suffering with histoplasmosis among non-HIV patients. (2) Methods: This is a single-center, retrospective study conducted at Cayenne Hospital Center between 2008 and 2022. (3) Results: Our cohort was composed of 31 (91%) adults (>18 years of age) and 3 (9%) children, with a sex ratio, M:F, of 1:2. The median age was higher among the women than among the men (70 versus 54 years). The collection of respiratory samples constituted the majority of the performed examinations (38%). Fever (>37 °C) was found in 56% of patients. Surprisingly, the histoplasmosis was disseminated in 82% of patients with an overall case fatality rate of 14.7%. However, immunosuppressive conditions were found in 52% (16/31) of the adult patients, including lymphoid hemopathies, diabetes and immunosuppressive drugs. Conclusions: This disease, though rare and usually considered a mostly benign disease in non-HIV patients, presented a relatively high mortality rate in our cohort. Thus, histoplasmosis should be suspected, screened and investigated as a first line of defense in highly endemic areas, even in immunocompetent and non-HIV patients, especially those with fever or chronic respiratory symptoms.
The Public Sphere Is “Too Darn Hot”: Social Identity Complexity as a Basis for Authentic Communication
Authors: Brundidge Jennifer
Published: June 2024

A growing body of research suggests that the contemporary media environment enables motivated reasoning, which intensifies affective polarization. This is especially the case in the U.S., where elections are capital-intensive and media are largely commercially owned. From a normative perspective, these commercial forces may interfere with authentic communication by hijacking the “lifeworld” and thus undermining the sincerity of our speech. From a psychological and empirical perspective, this means we are an affective public steeping in “hot cognitions” that unconsciously motivate us toward processing (mis)information in biased and distorted ways. This kind of cognitive limitation intensifies as current affairs heat up, but starts well before, as a function of media market boundaries aligning with human psychology. Through a synthetic literature review of theory and empirical research, this essay argues that “social identity complexity” may help to overcome some of the worst outcomes of motivated reasoning, pointing toward a developmental basis for more authentic communication in the public sphere.
Plastic Analysis with a Plasmonic Nano-Gold Sensor Coated with Plastic-Binding Peptides
Authors: Gagné Francois , Gauthier Maxime , André Chantale
Published: June 2024

Contamination with plastics of small dimensions (<1 µm) represents a health concern for many terrestrial and aquatic organisms. This study examined the use of plastic-binding peptides as a coating probe to detect various types of plastic using a plasmon nano-gold sensor. Plastic-binding peptides were selected for polyethylene (PE), polyethylene terephthalate (PET), polypropylene (PP), and polystyrene (PS) based on the reported literature. Using nAu with each of these peptides to test the target plastics revealed high signal, at 525/630 nm, suggesting that the target plastic limited HCl-induced nAu aggregation. Testing with other plastics revealed some lack of specificity but the signal was always lower than that of the target plastic. This suggests that these peptides, although reacting mainly with their target plastic, show partial reactivity with the other target plastics. By using a multiple regression model, the relative levels of a given plastic could be corrected by the presence of other plastics. This approach was tested in freshwater mussels caged for 3 months at sites suspected to release plastic materials: in rainfall overflow discharges, downstream a largely populated city, and in a municipal effluent dispersion plume. The data revealed that the digestive glands of the mussels contained higher levels of PP, PE, and PET plastic particles at the rainfall overflow and downstream city sites compared to the treated municipal effluent site. This corroborated earlier findings that wastewater treatment could remove nanoparticles, at least in part. A quick and inexpensive screening test for plastic nanoparticles in biological samples with plasmonic nAu-peptides is proposed.
Laboratories: A New Open Access Journal
Authors: Hodaifa Gassan
Published: June 2024

The modernization of society goes hand in hand with agricultural, industrial, and economic development, with this development becoming increasingly complex due to the large number of activities being carried out and the diversification of products generated by society [...]