bluuebunny/crossref_metadata_2025 huggingface dataset:
Technicko-prevádzkové charakteristiky pre rôzne aplikácie UAV
Authors:   University of Žilina, Valetskyi Maksym , Veľký Patrik
Published: November 2024

The goal of this bachelor's thesis is to create a system for analyzing technical and operational characteristics for various UAV applications. The work consists of 4 parts: the first part describes the current methods of qualification and separation of drones according to the above mentioned parameters, the second part analyzes in detail five different ways of using drones, the third part of the part selects the most important technical and operational ones based on the data from the previous part parameters and a table is created. In the last practical part, with the help of logical analysis, cause-and-effect relationships, methods of assumptions and results of the research, the relationships or so-called correlations entered in the table are investigated between the values listed in the table. This model helps to optimize the operation of the drone, save money on the purchase, maintenance and increase the safety of its operation.
Didaktické pomôcky veterného tunela
Authors:   University of Žilina, Hronská Marta , Pecho Pavol
Published: November 2024

The aim of the paper is to approach the issue of the flowing around didactic tools in the wind tunnel. Didactic tools are used for education and help in understanding the issue of aerodynamics. In the first part, the paper deals with theoretical knowledge about the wind tunnel and then describes the theory and laws of aerodynamics. The core of this work is the analysis of the given objects realized through numerical and experimental methods. By using CFD simulation of didactic tools, it was possible to obtain aerodynamic drag values, from which the values for the drag coefficient were calculated and then compared with tabular values from theory. Experimental verification of individual objects was carried out in a wind tunnel located at the Department of Air Transport in Dolný Hričov. The result of tests in the wind tunnel was the visualization of the air flow around the didactic aids. At the end of the work, both methods were compared and the reasons for deviations and inconsistencies were described.
The Role of Synaptopathy in Alzheimer's Disease: A Review of Key Transgenic Mouse Models
Authors: Sari Elif , Ahmad Hamdaan , Ng Teresa
Published: November 2024

Introduction: Long-term potentiation (LTP) and its counterpart, long-term depression (LTD), are considered the cellular basis underpinning learning and memory. Impairments in these processes are associated with neurodegenerative diseases such as Alzheimer’s disease (AD). These impairments are emergent during the onset of AD, suggesting a critical role in the pathophysiology of AD. Popular transgenic AD models, such as 5xFAD, 3xTg, Tau MAPT P301L, and APPswe/PSEN1dE9 demonstrate changes in synaptic plasticity early during their lifespan. This systematic review aims to investigate localization and onset of synaptopathy associated with AD. Methods: A comprehensive literature search was conducted using PubMed (Medline) to identify common features across models associated with synaptic plasticity. Papers were screened through two stages. The first stage involved establishing a set of criteria, including search terms. The second stage centered on ensuring chosen studies focused on synaptopathy and utilized the models selected. Results: Eight studies were selected across the four transgenic mouse models that established onset and localization of synaptopathy in AD pathophysiology. In the majority of studies, impairments in synaptic plasticity were first found in the CA1 region of the hippocampus. Moreover, onset of these impairments developed prior to onset of neuropathology and behavioral or cognitive deficits. Impairments in synaptic plasticity included inhibition of glutamate release, decreased cell excitability, dendritic atrophy and impaired receptor signaling. Discussion: The results of this review suggest localization of synaptic plasticity impairments to the CA1 region preceding development of neuropathologies such as amyloid or tau aggregation and cognitive deficits. This indicates an early and critical role of synaptopathy at the CA1 region, implicating it as a potential causal factor in the pathophysiology of AD. Conclusion: While the FAD models evaluated in this review implicate changes in synaptic plasticity within AD, they are not representative of late onset AD (LOAD), the prevalent form of the disease in the population. Currently research using LOAD models is limited, causing reliance on FAD models for the study of AD. As prevalence of AD increases in the population, it is essential that new models of LOAD are developed and studied to further current understandings of AD pathophysiology.
Role of Sustainable Green Supply Chain Practices in Enhancing Firm Performance and Competitive Advantage: The Mediating Role of Green Motivation and Corporate Culture
Authors: Farooqui Muhammad Hamza , Shamim Moona
Published: November 2024

Purpose: As firms increasingly adopt sustainable strategies to meet environmental regulations and market demands, challenges such as lack of investor interest, insufficient leadership awareness, and technical barriers hinder the full implementation of green initiatives. By analyzing the effects of green supply chain practices on both environmental and economic performance, this study aims to bridge the gap in existing research, which often overlooks the role of internal corporate dynamics in driving sustainable outcomes.
Design/Methodology/Approach: Data is collected from supply chain professionals and corporate leaders across various industries, using a structured questionnaire. A quantitative-method approach will be employed, with Partial Least Squares Structural Equation Modeling (PLS-SEM) used to analyze the relationships between GSCM practices, corporate culture, employee motivation, and firm performance.
Findings: The findings are expected to reveal that green motivation programs, sustainable corporate culture, and employee engagement play significant roles in enhancing the effectiveness of GSCM practices, leading to improved firm performance and competitive advantage.
Implications/Originality/Value: This study contributes to both theory and practice by highlighting the importance of aligning internal green initiatives with external sustainable supply chain practices. It provides valuable insights for firms seeking to leverage sustainability as a strategic tool to gain a competitive edge in the global marketplace. Future research directions and practical recommendations for corporate leaders and policymakers will also be discussed.
PENANGANAN ANEMIA PADA IBU HAMIL DESA MENGANTI KECAMATAN KESUGIHAN KABUPATEN CILACAP
Authors: Susilawati Susilawati , Kasron Kasron , Lestari Yogi Andhi
Published: November 2024

Anemia pada ibu hamil dapat berdampak terhadap anak yang di dilahirkan. Menganti merupakan salah satu Desa di Kabupaten dengan angka kejadian anemia pada ibu hamil tinggi, yang disebabkan karena rendahnya pengetahuan dan keterampilan tentang anemia pada ibu hamil. Metode pelaksanaan dengan pemberian makanan pendamping, promosi kesehatan, gerakan kesehatan ibu hamil, kunjungan rumah, kampanye giat pemeriksaan ANC dan konsumsi tablet tambah darah. Kegiatan pengabdian ini telah dilakukan dengan hasil pengabdian diperoleh bahwa peningkatan pengetahuan ibu hamil tentang anemia, peningkatan peran serta ibu hamil dalam kegiatan pemeriksaan ANC rutin dan peningkatan konsumsi TTG pada ibu hamil, serta tidak ada kasus anemia pada ibu hamil di Desa Menganti. Setelah pengabdian ini diharapkan tidak terdapat kasus ibu hamil dengan anemia di Desa Menganti di waktu yang akan datang
PENYULUHAN DAN DEMONSTRASI MENYIKAT GIGI TERHADAP KEJADIAN KARIES GIGI PADA ANAK SD NEGERI 1 BANDONGAN MAGELANG
Authors: Astuti Wahyu Tri , Marhamah Emah , Siswanto Siswanto , Nurhayati Nurhayati , Bening Alfisa Her , Hernando Firsty Berliane Orvala , Sari Vany Nela
Published: November 2024

Kesehatan gigi adalah kondisi umum dari gigi dan gusi seseorang yang mencakup pencegahan, diagnosis, dan perawatan berbagai masalah gigi dan mulut. Menurut sumber-sumber terkini, seperti World Health Organization (WHO) dan American Dental Association (ADA), definisi ini tetap konsisten dengan pandangan mereka sepanjang waktu. Kolaborasi dengan puskesmas atau tenaga kesehatan gigi dari luar sekolah dapat memperkuat program UKGS dengan menyediakan sumber daya tambahan, pelatihan, atau layanan spesialisasi. Program UKGS berfokus pada mencegah masalah kesehatan gigi sejak dini dan mempromosikan kebiasaan hidup sehat kepada siswa. Sasaran pengabdian kepada masyarakat ini adalah seluruh siswa-siswi kelas 1 yang berjumlah 35 siswa. Kegiatan pengabdian dilakukan setiap bulan selama 4 bulan yaitu Oktober 2023-Desember 2024 di SD N I Bandongan, dimulai dari perijinan, studi pendahuluan, sosialisasi dan pendampingan dan terakhir evaluasi. Alat yang dibutuhkan yaitu alat sosialisasi, alat menggosok gigi, alat periksa gigi, air, meja ATK dan formulir. Hasil kegiatan terjadi karies gigi sebanyak 30 anak, yang tidak terjadi karies sebanyak 5 anak, yang punya pengetahuan cara menyikat gigi dengan benar 13 siswa yang tidak benar sebanyak 21 anak. Simpulannya pendidikan kesehatan dengan metode demonstrasi dapat memberdayakan anak dengan pengetahuan, keterampilan, dan motivasi yang diperlukan untuk menggosok gigi agar mencegah terjadinya karies gigi pada siswa kelas 1 di SD N 1 Bandongan Magelang
PENYULUHAN PENTINGNYA SARAPAN SEHAT PADA ANAK KELAS 3 SD NEGERI 1 BANDONGAN MAGELANG
Authors: Wijayanti Novida Prima , Nurhayati Lis , Kurniawan Bagus , Suparti Suparti , Shochibah Nurush , Permata Indah Dwi , Tajudin Hajid
Published: November 2024

Latar belakang: Sarapan atau makan pagi merupakan modal energi untuk beraktivitas dalam satu hari. Anak usia sekolah memiliki tingkat aktiftas tinggi dan memerlukan fokus untuk menunjang kemampuan kognitifnya. Sarapan pagi memiliki banyak manfaat seperti menjaga mood dan konsentrasi, menjaga kesehatan jantung, mencegah obesitas dan mempengaruhi kemampuan kognitif. Derajat kesehatan siswa dapat ditingkatkan melalui pengetahuan sarapan sehat sesuai porsi dengan waktu yang tepat. Tujuan : Meningkatkan pengetahuan sehingga dapat membentuk kebiasaan sarapan sehat. Metode: Sosialisasi landasan teori, pendampingan dan evaluasi tentang sarapan sehat dilakukan selama bulan Oktober-Januari 2024. Hasil kegiatan: Terdapat peningkatan pengetahuan pada hasil pretest dan posttest pada pertemuan pertama dan saat evaluasi mayoritas siswa dapat membawa bekal dengan beragam nutrisi sesuai ketentuan sarapan sehat. Simpulan : Penyuluhan kesehatan melalui metode kelompok terbukti efektif dalam meningkatkan pemahaman siswa kelas 3 di SD N 1 Bandongan Magelang mengenai pentingnya sarapan sehat yang bergizi dan lengkap.Kata kunci: Anak usia sekolah, pendidikan kesehatan, sarapan sehat
PENDAMPINGAN DETEKSI DINI GAGAL TUMBUH BERAT BADAN (WEIGHT FALTERING) PADA IBU BALITA
Authors: Bara Farida Tandi , Nopiyanti Nopiyanti , Pricelo Helen , Nurvianthi Riska Yuli
Published: November 2024

Latar Belakang: Gagal tumbuh berat badan (Weight faltering) merupakan kondisi ketika anak tidak mengalami penambahan berat badan sesuai yang diharapkan untuk usianya(Aylicia & Wijaya, 2022). Kondisi ini jika terjadi dalam periode yang panjang, dapat mengalami stunting. Peran orang tua sangat penting dalam mencegah dan mengatasi weight faltering pada anak. Kegiatan ini bertujuan untuk meningkatnya pengetahuan ibu tentang weight faltering dan melibatan orang tua dalam pengukuran berat badan dan pemantauan pada grafik berat badan di buku KIAMetode: Metode pelaksanaan pengabdian ini terdiri dari 4 tahap, yaitu perencanaan kegiatan. Pelaksanaan tahap 1 yaitu survei lapangan dan diskusi diskusi untuk penentuan solusi permasalahan. Pelaksanaan tahap 2: Edukasi Kesehatan deteksi gagal tumbuh berat badan pada ibu bayi dan balita dan keterlibatan ibu dalam pemantauan tumbuh bayi dan balita yang dilaksanakan pada tanggal 16 Juni 2024 di posyandu Mawar Kelurahan MinasateneHasil: Sebanyak 19 ibu balita yang berkunjung mengikuti penimbangan BB dilakukan oleh ibu didampingi Tim pengabdian masyarakat. Kebiasaan makan anak yang kurang baik dan PMT yang tidak sesuai menjadi penyebab masalah berat badan anak tidak bertambah.  Semua ibu mengetahui jika berat badan anak tidak bertambah dalam jangka panjang dapat menyebabkan stunting.Kata Kunci: Weight faltering,  Edukasi Kesehatan, Deteksi Dini
PEMBENTUKAN KADER AISYIYAH PEDULI KESEHATAN PCA SEMPOR DALAM DETEKSI DINI DAN PENCEGAHAN PENYAKIT HIPERTENSI PADA LANSIA
Authors: Yuda Hendri Tamara , Ernawati Ernawati , Saraswati Rina , Kuncoro Taufik Jati , Prakoso Fajar Ferdi , Andriyani Lisa , Kaulitsabit Zulfikar Bira
Published: November 2024

Pemerintah menginisiasi penanganan kesehatan lansia serta mengatasi dampak dan tantangan kesehatan akibat pertumbuhan populasi melalui kolaborasi dengan pemerintah pusat, pemerintah daerah, organisasi masyarakat, sektor swasta, dan organisasi internasional. Aisyiyah adalah organisasi wanita yang merupakan bagian dari Muhammadiyah.Aisyiyah memiliki banyak program diantaranya program kesehatan. Hasil wawancara dengan Ketua PCA Sempor bahwa kader belum pernah diberikan informasi terkait hipertensi, sedangkan ada beberapa keluarga yang menderita hipertensi. Kader belum paham bagaimana melakukan deteksi dini pada kasus hipertensi Kader Dalam keseharian kader Aisyiyah berbaur dengan masyarakat sekitar sehingga kader tersebut bisa menjadi pioneer dalam hal kesehatan di masyarakat salah satunya terkait deteksi dini dan pencegahan penyakit hipertensi di keluarga. Solusi yang ditawarkan pada kegiatan ini adalah pembentkan kader kesehatan untik meningkatkan pengetahuan kader Aisyiyah dalam deteksi dini dan pencegahan hipertensi pada lansia. Kegiatan pengabdian masayarakat ini diikuti 50 kader PCA Sempor. Hasil kegiatan menunjukkan bahwa setelah pelaksanaan, mayoritas kader memiliki tingkat pengetahuan yang baik, dengan jumlah mencapai 25 orang, atau 50% dari total peserta. Kesimpulan dari kegiatan pengabdian kepada masyarakat ini menunjukkan adanya peningkatan pengetahuan kader PCA mengenai deteksi dini dan pencegahan hipertensi pada lansia
Membina wirausahawan masa depan: Peran inkubator bisnis dalam membentuk niat berwirausaha di perguruan tinggi
Authors: Dharmastuti Christiana Fara , Lembana Devi Angrahini Anni , Sustaningrum Rakhdiny
Published: November 2024

Kewirausahaan memainkan peran penting dalam pembangunan nasional. Oleh karena itu, pelatihan terkait sering diinisiasi di tingkat universitas untuk membekali mahasiswa dan mahasiswi dengan keterampilan kewirausahaan setelah kelulusan melalui inkubator bisnis. Penelitian ini mengeksplorasi peran penting inkubator dalam menumbuhkan intensi berwirausaha di kalangan mereka dengan mempertimbangkan pengaruh jenis kelamin, pendampingan, dan desain kurikulum untuk proses pembelajaran. Selain itu, riset ini menganalisis dampak dukungan universitas secara regulasi, normatif, dan kognitif.  Selanjutnya, data dikumpulkan dari tiga kelompok peserta inkubator dalam periode waktu yang berbeda. Hasil temuan studi ini menunjukkan intensi berwirausaha berdasarkan jenis kelamin, yang mana pria menjadi kategori referensi berpengaruh secara positif. Selain itu, tendensi positif dari dukungan lingkungan normatif dan kognitif terhadap intensi ini terjadi. Namun, pendampingan, program kurikulum, dan dukungan lingkungan regulatif tidak berpengaruh terhadap intensi ini.
Safety and efficacy of a feed additive consisting of ponceau 4R for its use in baits for freshwater fish (GIFAP)
Authors:   EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa Roberto Edoardo , Azimonti Giovanna , Bonos Eleftherios , Christensen Henrik , Durjava Mojca , Dusemund Birgit , Gehring Ronette , Glandorf Boet , Kouba Maryline , López‐Alonso Marta , Marcon Francesca , Nebbia Carlo , Pechová Alena , Prieto‐Maradona Miguel , Röhe Ilen , Theodoridou Katerina , Bastos Maria , Bories Georges , Brantom Paul , Gropp Jürgen , Svensson Kettil , Tosti Luca , Finizio Antonio , Dioni Anna , Galobart Jaume , Holczknecht Orsolya , Pizzo Fabiola , Vettori Maria Vittoria , Amaduzzi Angelica
Published: November 2024

Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of ponceau 4R as sensory additives (functional group: (a) colourants: (i) substances that add or restore colour in feedingstuffs). The additive is already authorised for use with cats and dogs and ornamental fish. The additive is intended to be incorporated in freshwater fishing baits up to a maximum of 15 mg/kg in complementary feed in order to colour them. The additive is intended to be incorporated into feed directly in solid form or via an aqueous solution. The additive is not intended for use in aquaculture. The FEEDAP Panel concluded that ponceau 4R is considered safe when used in fish baits for freshwater fish at the maximum proposed dose of 15 mg/kg complementary feed. The use of the feed additive ponceau 4R fish baits for freshwater fish under the conditions of use proposed is of no concern for consumer safety. Ponceau 4R is not skin irritant but should be considered a skin and respiratory sensitiser. Inhalation and dermal exposure are considered a risk. The FEEDAP Panel could not conclude on the eye irritation potential of the additive. In absence of data no conclusion can be reached on the efficacy of ponceau 4R in freshwater fish baits.
ROLE OF MEDIATION IN FACILITATING ACCESS TO JUSTICE IN ITS TRUE ESSENCE: A CRITICAL ANALYSIS
Authors: Mishra Ashutosh , Kharat Madhuri , Acharya Ashutosh , Sonawane Ajay , Shukla Shruti , Maurya Suraj Kumar
Published: November 2024

The concept of justice is not novel, and so is Mediation. Since the inception of human interactions, disagreements and disputes have been a part of living. When Indian legal System was being formed, it was designed following the adversarial system that seem to favour the strong party and follow the already written law points with little or no room for creative solutions. Also, there are several provisions and arrangements made to extend the access of legal corridors to the underprivileged and left out segments of the society; but this does not ensure that justice has been realised in its true essence. Mere access to legal means, is not access to justice too. This is where Mediation as a means of alternative dispute resolution steps in and creates a comfortable, private, inexpensive and self- determined environment for both the parties at dispute. This paper examines what is true justice and what our constitution makers had in mind in relation to notion of justice when they attempted to give us the related rights. Justifying the stance with real life scenarios and cases, the paper also elucidates how Mediation can help parties achieve justice in its real sense and not just literal or technical.
कला, कौशल और ज्ञान: भारतीय ज्ञान परंपरा का शिक्षणशास्त्रीय विवेचन
Authors: Chandoria Virendra Kumar , Singh Pooja , Surjan Praveen Kumar , Chauhan Sumit Kumar Singh
Published: November 2024

भारतीय ज्ञान परंपरा एक प्राचीन परंपरा रहीं है। वर्तमान में भारतीय ज्ञान परंपरा को अपनाने के आग्रह के संदर्भ में एक सवाल शास्वत हो उठता है कि भारतीय ज्ञान परंपरा में शिक्षा और शिक्षण से जुड़ी कौन-कौन सी अवधारणाएं रही हैं और वे समय के साथ कैसे परिवर्तित और संवर्धित होती रही हैं ? एक और महत्वपूर्ण सवाल यह है कि हमारी प्राचीन परंपरा में शिक्षा का नियोजन किस प्रकार किया जाता था? कई सदियों से यह प्रश्न जिज्ञासा का एक बड़ा विषय भी रहा है। यह प्रश्न इसलिए भी ज्यादा लाज़मी बन जाते है क्योंकि हम एक पश्चिमी उपनिवेशिक शिक्षा पद्यति का अनुसरण कर रहें है इसलिए यह सवाल कि वर्तमान शिक्षा में प्रचलित पश्चिमी अवधारणाओं से भारतीय परंपरा कहां तक अलग हैं? इस क्षेत्र में सुस्पष्ट सामग्री का अभाव भी सुविदित ही है। विभिन्न समाजों की परंपराओं का अध्य्यन करने पर एक महत्वपूर्ण तथ्य उभर कर आता है कि सभी समाज विकास के अपने क्रम में सीखने-सिखाने की अपनी परंपराएं विकसित करते आये हैं। इतना ही नहीं इन परम्पराओं ने शिक्षार्थी को ज्ञान संप्रेषित करने के तरीके भी खोजे हैं। यह भी सर्वविदित है कि कोई भी परंपरा स्थिर और स्थायी नहीं होती है। समय के साथ उसमें बदलाव आते हैं। भारतीय परंपरा में सीखने-सिखाने का क्या स्वरूप रहा है और समय के साथ वे भी कैसे बदली हैं? शिक्षक की अवधारणा में किस तरह के बदलाव आए हैं और इन बदलावों के साथ साथ अवधारणा कैसे बदली हैं? और इन बदलावों में किस तरह के दवाब हावी रहे हैं? साथ ही इन सभी के केंद्र में ज्ञान, विद्या और कौशल के बीच स्पष्ट ज्ञानमीमांसीय अन्तर को समझने का प्रयास के साथ उपर्युक्त सभी मुद्दों का शिक्षणशास्त्र के संदर्भ में दस्तावेजी अध्ययन किया गया है, जिन्हें इस आलेख में शामिल किया गया है।
THE ELECTORAL BONDS DILEMMA: BALANCING POLITICAL FUNDING WITH ELECTION FAIRNESS
Authors: Sinha Anju
Published: November 2024

The concept of electoral bonds offers a difficult conundrum at the junction of fair elections and political finance openness. Originally meant to simplify political contributions in India, electoral bonds enable supporters of political parties to remain anonymous, therefore presumably lowering uncontrolled cash flow.  Proponents of this financing strategy claim it allows a simpler, more direct approach for donations without violating donor privacy, which may be particularly important in a politically sensitive climate that has polarizing public opinion. Critics counter that by letting unreported sums into political campaigns, it lessens democratic responsibility and shifts the balances in favor of those with more financial support.
ANALISIS POTENSI BAHAYA TERHADAP KUALITAS IKAN LAYANG DI PIM MUARA BARU JAKARTA
Authors: Tiaraningtyas Dyah Ayu
Published: November 2024

Pasar Ikan Modern Muara Baru yang terinspirasi oleh Pasar Tsukiji di Tokyo, Jepang, mulai beroperasi pada tahun 2019. Ikan layang menjadi komoditas utama karena daya tarik sensoriknya yang tinggi, sehingga meningkatkan permintaan pasar. Salah satu jalur transportasi terdekat yang mensupply ikan layang PPS Nizam Zachman memiliki jarak 2 km. Setibanya di PIM Muara Baru, ikan layang tersebut berada dalam kondisi yang kurang baik. Dikarenakan moda transportasi pengiriman menggunakan kendaraan dengan mobil bak terbuka ( pick-up ), terdapat ikan ditempatkan tidak sesuai dengan standar penanganan dalam penyimpanan dan tidak menerapkan persyaratan rantai dingin. Penelitian bertujuan untuk identifikasi dan transportasi ikan layang di Dermaga PPS Nizam Zachman dan bongkar muat PIM Muara Baru, menghitung tingkat risiko yang mempengaruhi kualitas ikan dan menyusun rekomendasi untuk mencegah penurunan kualitas ikan. Penelitian menggunakan metode Risk Assesment untuk menentukan tingkat risiko berdasarkan ( probabilitas ) dan ( severity ). Hasil penelitian diperoleh 9 aktivitas untuk dua model transportasi, yang telah teridentifikasi 81 potensi bahaya, dikategorikan tingkat risiko sangat tinggi sebesar 43% selama penanganan dan transportasi. Upaya perbaikan yang dilakukan meliputi pembuatan SOP keselamatan, penerapan sanksi bagi pelanggar, serta pemantauan dan evaluasi tahunan oleh instansi yang berwenang. Rekomendasi juga mencakup perhitungan yang akurat untuk penggunaan transportasi yang berpendingin.
Why teach nurses: a manager’s perspective
Authors: Levashova V.V.
Published: November 2024

Training of medical personnel is a mandatory element of medical institution functioning, and the responsibility for training of medical workers lies entirely on the management of the medical institution. In this article, the author examines 3 types of training approaches.
Clinical research. The path of a drug from history to pharmacologic research
Authors: Zhuravleva E.S.
Published: November 2024

In the article we will touch upon the history of the emergence of clinical trials of medicines and the need for these trials, we will analyze why evidence-based medicine is needed. Let’s look into the history of clinical trials, in what years and how the drug trials were conducted, on what animals. We will learn how science evolved to prove the detrimental effects of drugs widely used in a certain period of time, as well as the discovery of insulin therapy as a factor that reduces the risk of death. Clinical scientific research with human participants is necessary, it is conducted to assess the efficacy and safety of a new medicinal product or to expand the indications for the use of an already known medicinal product. The procedure of registration of a new medicinal product is carried out by the state in order to determine the quality of the new medicine, its benefits and possible risks of use. Let us consider in detail the scheme of registration of medicinal products. All clinical trials of medicinal products for medical use are conducted in one or several medical organizations in accordance with the rules of good clinical practice, in accordance with the fundamental ethical principles of the Declaration of Helsinki and other normative documents regulating the protection of rights, safety and health of the tested (volunteer) patient over the interests of science and society. There are 4 phases of clinical trials, which will be discussed in detail in the article.
Senior nurse: what competencies should be developed and why?
Authors: Koroleva I.V.
Published: November 2024

The article deals with the tasks of the head of nursing service, as well as the competence profile: what groups of competences it consists of, what specific knowledge, skills and abilities can be developed in the head nurse, and why these competences will be useful in performing managerial labor functions. Special attention is paid to the area of personnel management and direct interaction with subordinates.
Rethinking approaches to sterilization in dentistry: multidrug resistance and new challenges in the COVID-19 era
Authors: Sarkisyan N.G. , Brudyan G.S. , Mikhailov V.D. , Melikyan А.G. , Osipova I.M.
Published: November 2024

The article explores an integrated approach to managing infectious risks in dentistry, starting with the issue of multidrug resistance and ending with modern methods of sterilization and disinfection. Special attention is paid to changes in infection control practices in the context of the COVID-19 pandemic. The advantages of using laminar flow cabinets as an effective means of ensuring sterile conditions are discussed.
Prevention of oncological diseases in the work of nursing staff
Authors: Skvortsov V.V. , Tagiyev F.Z , Durnoglazova K.A.
Published: November 2024

Cancer prevention is currently divided into primary and secondary prevention. Primary prevention is a set of measures that prevents the development of the cancer process and includes, for example, health counseling and education, environmental control and product safety. Secondary prevention is a set of measures leading to the detection and control of cancer or precancerous processes at their localization, that is, screening, early detection and effective treatment. The risk of developing cancer exists throughout life for everyone, although it can vary in intensity in different groups. Together, primary and secondary prevention should be combined into optimal strategies throughout life that are best understood and evaluated in accordance with certain basic concepts of cancer epidemiology. The purpose of this article is to give a brief overview of these concepts applied to primary and secondary cancer prevention in humans. A deeper understanding of these concepts is essential for planning, implementing and evaluating prevention programs.
Influence of hypodinamia on human health
Authors: Evstigneeva A.S. , Sukhovey L.V.
Published: November 2024

The relevance of this topic is due to the significance of the influence of a healthy lifestyle, and in particular, optimal physical activity, on the human body. Nowadays, there are not many jobs left that require physical activity. Labor is so automated that many people may not get up from their desks during the entire working day. Yes, after work, public and personal transport does not require serious mobility. Gradual weakening of muscles and tone of the walls of arteries and veins, an increase in the volume of adipose tissue and a decrease in bone tissue, a decrease in lung capacity and endurance — these are just some of the pathological changes that occur in the body if it is limited in regular physical activity Health is one of the most important life values of a person, the key to his well-being and longevity.
Prevention of pre-hypertension in medical college students by means of therapeutic physical training
Authors: Lyubushkina M.V. , Dasko T.G.
Published: November 2024

According to the World Health Organization, prehypertensive or “at risk” patients have a systolic blood pressure of 120 to 139, diastolic blood pressure of 80 to 89. Risk factors for prehypertension: sedentary lifestyle, high salt intake, calcium deficiency, bad habits – alcohol abuse, smoking, stress factors, for example, night work, frequent anxiety, psychological shocks. Separately, burdened heredity is distinguished. If there is prehypertension or hypertension in close relatives, the risk of developing prepathology, and then pathology, increases. Obesity and physical inactivity increase the likelihood of the disease occurring.
Hospitalidade
Authors: Ramos Waleska Camargo Coelho
Published: November 2024

Este e-book que ora apresentamos aos leitores pode ser considerado um mosaico social, frise-se, não propondo a palavra final, como convém à honestidade científica, mas promovendo a diminuição de incertezas e proporcionando a criação de um feixe de probabilidades de estudos da área. O e-book é composto por onze artigos, escritos por
22 autores.
Cada um desses estudos oferece uma visão de como a hospitalidade pode ser aplicada e valorizada em diferentes contextos, mostrando seu impacto positivo na qualidade do atendimento, na sustentabilidade,
na gestão de pessoas e na inovação tecnológica. Juntos, esses textos destacam a importância de práticas hospitaleiras para o desenvolvimento e sucesso em diversas áreas.
O papel do professor na inclusão escolar
Authors: Santos Rosangela Maria dos , Santos Rosane Maria dos , Nascimento Cácia Aparecida Souza , Silva Reigiane Xavier da , Fonseca Vanessa Barbosa Costa da
Published: November 2024

A era digital, com sua velocidade frenética de acesso à informação e avanços tecnológicos, trouxe consigo desafios complexos para a educação. A falta de tempo familiar para a construção de vínculos e a compreensão da individualidade das crianças, somada à influência de discursos preconceituosos, muitas vezes disfarçados de "brincadeiras", criam um terreno fértil para a intolerância e a discriminação. É nesse contexto que o papel do educador se torna crucial na formação de cidadãos conscientes e inclusivos. O educador, nesse contexto, assume o papel de agente transformador, combatendo a exclusão e promovendo a valorização da diversidade. A escola, nesse sentido, se torna um espaço privilegiado para a construção de uma cultura de respeito e acolhimento, onde as diferenças são celebradas como elementos enriquecedores para o grupo. O educador, através de atividades pedagógicas e de exemplos positivos, deve auxiliar as crianças a desenvolverem a capacidade de reconhecer e respeitar as diferenças, construindo um ambiente escolar mais justo e igualitário. O educador, como mediador e orientador, é essencial para construir um ambiente escolar que promova a inclusão e a valorização da diversidade, preparando as crianças para uma sociedade mais justa e igualitária.
ESTÉTICA Y ÉTICA EN LA PROPUESTA DE HANS-GEORG GADAMER EN CONTRASTE Y COMPLEMENTO DE LA PROPUESTA ESTÉTICA DE ALFONSO LÓPEZ QUINTÁS.
Authors:   , Álvarez Vidal Rodrigo Patricio
Published: November 2024

Este documento articula una relación entre estética y ética, particularmente, entre las propuestas del filósofo alemán Georg-Hans Gadamer en su texto La actualidad de lo bello (1977), y la propuesta del español Alfonso López Quintás en su texto Estética de la Creatividad: Juego, arte, literatura (1998).
La manera en que se despliega esta relación entre estética y ética es unidireccionalmente desde estética hacia ética, desarrollándose por medio de vivir de experiencias estéticas ya sea obra de arte, símbolo, o fiesta para luego converger en reflexiones éticas.
Este problema se esclarece por medio tres partes: la primera, donde se desarrollan los tópicos que presenta Gadamer referenciándolos como ejes de la problemática; la segunda, donde se despliegan los contenidos desarrollados por López y a su vez puedan ser contenido en los tópicos de Gadamer. Y, la tercera, donde se ponen en discusión la perspectiva de ambos autores concluyendo con reflexiones finales sobre la relación entre estética y ética, tanto en lo formal como con un ejemplo proyectado hacia el futuro de la educación musical.
Introducing the Muslim Rolodex: The Hiring of Us Imams
Authors: Khalil Nancy A. , Zaidi Safiyah
Published: November 2024

Abstract: This article argues that as the profession of the imam continues to evolve and grow in the US, American Muslims utilize trusted Muslim networks and contacts, referred to here as a Muslim Rolodex , as an indispensable component of evaluating and hiring imams. To illustrate this, we put qualitative coding and analysis of resumes for an imam search at a Boston mosque in conversation with its job announcement, promotional material, and a case study conducted by a third party on this imam hiring process. We examine all of this submitted material to understand what US Muslims and institutions value and expect when choosing a leader to represent their congregations. Our findings indicate that the Rolodex is commonly leveraged by Muslims across the country to assess potential imams, who largely continue to prioritize and emphasize their believed traditional Islamic values in their job applications and styles of pastoral leadership. Resumen: Este artículo sostiene que a medida que la profesión del imán continúa evolucionando y creciendo en los EE. UU., los musulmanes estadounidenses utilizan redes y contactos musulmanes confiables, denominados aquí archivo rotativo musulmán, como un componente indispensable para evaluar y contratar imanes. Para ilustrar esto, comparamos la codificación y el análisis cualitativo de los currículums de una búsqueda de imán en una mezquita de Boston con su anuncio de trabajo, material promocional y un estudio de caso realizado por un tercero sobre este proceso de contratación de imanes. Examinamos todo el material presentado para comprender qué valoran y esperan los musulmanes y las instituciones estadounidenses al elegir un líder para representar a sus congregaciones. Nuestros hallazgos indican que los musulmanes de todo el país suelen utilizar el archivo rotativo para evaluar a los imanes potenciales, quienes en gran medida continúan priorizando y enfatizando los valores islámicos tradicionales que creen en sus solicitudes de empleo y estilos de liderazgo pastoral.
Discipline and Punishment in the Antebellum Upper Southeast
Authors: Logan Dana
Published: November 2024

Abstract: Evangelicalism’s role in the history of modern discipline can be seen through two genealogical threads: the reforming and the punitive. Michel Foucault’s account of the modern self aligns with the reforming thread, where self-examination is central, aiming to transform society by preventing future disruptions through individual self-reflection and narration. This discipline is evident in carceral and therapeutic institutions, and evangelical conversion plays an important historical role in the development of this disciplinary structure. The punitive thread is also deeply connected to evangelical history. Punitive evangelical punishment was practiced through intimate, mutual surveillance, notably in interracial Baptist churches of the antebellum South. Unlike Foucault’s narrative of self-narration in discipline, Baptist discipline was verbally limited and face-to-face, emphasizing humiliation and maintaining patriarchal structures. The history of Baptist discipline, or “watch-care,” is useful for thinking through the relationship of religion and policing in American history as both developed out of the patriarchal rights of the father and the desire to manage populations on the move. Resumen: El papel del evangelismo en la historia de la disciplina moderna puede verse a través de dos hilos genealógicos: el reformista y el punitivo. La explicación de Michel Foucault sobre el yo moderno se alinea con el hilo reformista, donde el autoexamen es central, con el objetivo de transformar la sociedad evitando futuras perturbaciones a través de la autorreflexión y la narración individuales. Esta disciplina es evidente en instituciones carcelarias y terapéuticas, y la conversión evangélica juega un papel histórico importante en el desarrollo de esta estructura disciplinaria. El hilo punitivo también está profundamente conectado con la historia evangélica. El castigo evangélico punitivo se practicaba mediante una vigilancia íntima y mutua, especialmente en las iglesias bautistas interraciales del sur anterior a la guerra. A diferencia de la narrativa de Foucault sobre la auto narración en la disciplina, la disciplina bautista era verbalmente limitada y cara a cara, enfatizando la humillación y manteniendo estructuras patriarcales. La historia de la disciplina bautista, o “vigilancia”, es útil para reflexionar sobre la relación entre religión y vigilancia en la historia estadounidense, tal como ambas se desarrollaron a partir de los derechos patriarcales del padre y el deseo de gestionar las poblaciones en movimiento.
CHALLENGES FACING SUSTAINABLE ENTREPRENEURSHIP
Authors: Stoica Mariana
Published: November 2024

The concept of sustainable entrepreneurship is becoming an increasingly pivotal area of focus in the global effort to address a range of pressing challenges, including climate change, resource scarcity, and social inequality. Entrepreneurs who integrate economic, environmental, and social goals into their business models can serve as pivotal agents in achieving both profitability and societal well-being. Nevertheless, despite the growing interest in sustainable business models, entrepreneurs encounter considerable obstacles that impede the scalability and success of their ventures. This study focuses on the identification and analysis of the principal obstacles across five key dimensions: economic, regulatory, social, technological, and environmental. The aim of this research is to examine the difficulties encountered by those engaged in sustainable entrepreneurship and to suggest strategies for surmounting these challenges. Methodologically, the study employs a multi-dimensional approach, with each challenge examined through qualitative analysis. The economic challenges, including the high initial costs and difficulties in accessing funding, are identified as some of the most significant barriers. The presence of regulatory challenges, such as inconsistent environmental policies and the absence of governmental incentives, serves to further complicate the business landscape. Furthermore, social challenges, such as consumer reluctance to pay higher prices for sustainable products and resistance to adopting new, eco-friendly habits, also play a crucial role in hindering the success of sustainable ventures. Furthermore, the absence of access to sophisticated green technologies and the requisite expertise to deploy them constitutes a substantial technological impediment for entrepreneurs. The results of the study indicate the existence of several potential avenues for addressing these challenges. For example, the increasing consumer demand for environmentally friendly products and services, in conjunction with technological advancements, presents a substantial opportunity for sustainable entrepreneurship. The practical value of the research lies in its strategic recommendations, which encourage collaboration between policymakers, businesses, and investors. Such collaborative endeavours can facilitate the creation of an enabling environment for sustainable entrepreneurship, thereby reducing economic and regulatory burdens while simultaneously promoting technological advancements. In conclusion, the study emphasises the necessity of a coordinated approach in order to overcome the barriers faced by sustainable entrepreneurs. By capitalising on emerging opportunities and cultivating a supportive ecosystem, entrepreneurs can simultaneously achieve financial success and a positive impact on society and the environment.
COMPARATIVE ANALYSIS OF THE COMPETITIVENESS OF UKRAINE'S ICT SECTOR: AN INTERNATIONAL PERSPECTIVE
Authors: Zavhorodnya Elizaveta , Melnyk Tetyana
Published: November 2024

The purpose of the paper is to examine the international competitiveness of Ukraine's ICT sector through a comparative analysis with 30 countries, identify its strengths and weaknesses, and provide actionable insights for policymakers, industry stakeholders and investors to improve Ukraine's position in the global ICT market. Methodology. The research employs the composite index methodology to assess the international competitiveness of Ukraine's information and communication technology (ICT) sector. The original ITSIC comprises 35 indicators; however, this has been expanded to 58 in order to provide a comprehensive view of the competitive advantages and position of the ICT sector in the global ICT market. Results. The article presents the findings of a comparative study of the ICT sector of Ukraine with global and regional leaders in the global ICT market. In order to identify the factors influencing the formation of competitive advantages, the following groups of factors were taken into account: the state of ICT infrastructure, the availability of qualified and competent IT professionals, the state and favourability of the political and business environment, the innovative potential of the ICT sector and its involvement in international trade and cooperation. The calculations have yielded the ratings for each group of indicators and the composite index as a whole, which identify the leaders in both global and regional dimensions. Specific consideration is given to the positioning of Ukraine's ICT sector within the context of the surveyed countries, with a focus on the identification of its competitive advantages and disadvantages within the global ICT market. Consequently, it has been determined that the international competitiveness of the domestic ICT sector between 2018 and 2022 was most significantly influenced by the extent of its involvement in international trade and collaboration, the availability and proficiency of the talent pool, and the quality of the ICT infrastructure. In conclusion, this study has identified the factors and trends that have the potential to impede Ukraine's ascension as a global leader in the ICT sector. Practical implications. The findings of the study may prove beneficial to a number of parties, including public authorities, ICT companies, investors and venture capitalists, educational and research institutions, international organisations and development agencies, IT entrepreneurs and the general public. The value and originality of the study can be found in its comprehensive, data-driven, and context-specific analysis, which provides actionable insights and strategic recommendations to enhance the international competitiveness of Ukraine's ICT sector.
SHIPBUILDING OF SOUTHERN UKRAINE: FROM STATE MONOPOLY TO CLUSTER INTEGRATION
Authors: Parsyak Volodymyr , Zhukova Оlena
Published: November 2024

The purpose of this article is to determine the prospects of Ukrainian shipbuilding, based on a review of its historical development. Methodology. In this study, the authors used a mix of methods for collecting, systematising and processing information. Primary data was collected through a review of thematic publications and research conducted by predecessors. Retrospective analysis was used to identify trends in the historical development of the shipbuilding sector of the domestic economy. Statistical analysis was used to determine its current state and foreseeable future. Results. Since Porter's introduction of the cluster theory, the Ukrainian shipbuilding business has failed to take advantage of the benefits it has offered. It has been reckless in building cluster potential as a tool for local economic development and community (hromada) management. While most shipbuilding and related enterprises are concentrated in the areas limited by the administrative boundaries of the country's Black Sea regions. Pessimists insist that the chances of success have been lost completely and irrevocably. The authors, on the other hand, based on a generalisation of current practice, observe the Phoenix effect. The authors illustrate it empirically. In particular, on the example of the Ukrainian Maritime Cluster (UMC). Practical implications. The first part of the article explores the former power of Ukrainian shipyards. The second part discusses the constructive initiatives of the modern shipbuilding business. The third part highlights the initiative to create the UMC. Value / Originality. This paper adds to the existing understanding and provides empirical evidence of the strong and untapped potential of the country's shipbuilding cluster. It also focuses on its attractiveness for cooperation with foreign investors after the onset of peace. The originality of this study lies in the holistic study of shipbuilding practice in the context of development. The authors are optimistic despite the war and the tragic consequences that accompany it.
OPTIMISATION OF STRATEGIES FOR WORKING WITH COUNTERPARTIES AND RISK MANAGEMENT AT UTILITY INFRASTRUCTURE ENTERPRISES
Authors: Chepurna Olena , Razinkin Nikita
Published: November 2024

The objective of this paper is to examine and enhance strategies for managing relationships with counterparties and mitigating risks in utility infrastructure enterprises. The paper seeks to analyse contemporary approaches and challenges faced by these enterprises, offering recommendations for improving their strategies in counterparty interactions and risk management. Ultimately, the goal is to enhance operational stability, competitiveness, and sustainable development in a dynamic business environment. Methodology. The research presents a critical review and analysis of the existing risk management and counterparty strategies employed by utility infrastructure enterprises. The methodology comprises an examination of current practices, the identification of key problems, and an evaluation of modern approaches, including digital transformation, process automation, and innovative management methods. By synthesising existing research and case studies, the paper identifies the strengths and weaknesses of various strategies and recommends improvements. Results. The analysis identified several key challenges faced by utilities in managing counterparties and risks, including inadequate risk management systems, outdated business processes and poor communication. Process automation, digital transformation and improved stakeholder integration are identified in the document as critical factors for optimising operations. It also emphasises the importance of careful selection of counterparties, performance monitoring and staff development to mitigate risks and foster better partnerships. Practical implications. The recommendations set forth in the paper provide actionable strategies for utility infrastructure enterprises to optimise their management of counterparties and risks. The implementation of these strategies, including the utilisation of digital tools, enhanced internal communication and a focus on staff development, can facilitate improvements in efficiency, risk management and long-term sustainability for utility companies. These recommendations are particularly beneficial for those in managerial or decision-making roles who are seeking to navigate the complexities of a rapidly evolving business environment. Value / Originality. This paper makes a significant contribution to the field by offering a comprehensive analysis of the strategies available for optimising counterparty relations and risk management in the utility sector. The value of this approach lies in its integration of modern technological solutions with traditional risk management practices. By offering practical, research-based recommendations, the paper addresses current gaps in the literature and provides new insights into how utility enterprises can better manage both internal and external challenges.