bluuebunny/crossref_metadata_2025 huggingface dataset:
Television audience in European Minority Languages: Reality, demographic profile, and correlation
Authors: Castañeda-Zumeta Aitor , Zabaleta-Urkiola Iñaki , Arriaga-Azkarate Tania
Published: December 2024

This article investigates the audiences of seven television stations of public ownership and general content and reach, broadcasting in Basque, Catalan, Frisian, Galician, Irish, Scottish Gaelic, and Welsh languages. The study (2021-2022) focuses on the audiences' quantitative dimensions and demographic profile and their correlation with the concept of mutual linguistic intelligibility, defined as the degree of understanding between minority and majority languages. A worthy and original finding reveals that those channels with a high degree of mutual linguistic intelligibility get a notably higher share (10-15%) than those with a very low degree of mutual intelligibility (1-3% share). The comparison of the audience metrics of minority-language televisions with those of majority-language public channels discloses challenging results. Regarding demographic profiles, there are evident audience differences among the seven televisions. At the European level, women represent 52.8%, and on the age variable, 65% of the audience is over 55.
El periodismo deportivo en Uruguay: dependencia del fútbol y diferencias en la cobertura respecto a otras disciplinas
Authors: Fernández Fernández José Gabriel , Pérez Álvarez Álvaro
Published: December 2024

El periodismo deportivo sigue en constante evolución en todo el mundo. Pasión y entretenimiento se combinan de la mejor manera gracias a los éxitos de muchos deportistas y a una narrativa de emoción que han agrandado muchos periodistas. La utilización del deporte como elemento integrador ha provocado además que este periodismo especializado se consolide. Sin embargo, se observa un exceso en la información de fútbol sobre otros deportes. Uruguay, un país de enorme tradición futbolística, no es ajeno a estas tendencias y así lo demuestra este estudio, que analiza los contenidos publicados en las secciones deportivas de los dos principales diarios de Uruguay, El País y El Observador, y entrevista a diversos periodistas deportivos uruguayos, confirmando una sobreabundancia de información de fútbol, pues 4 de cada 5 textos analizados se dedican a ese deporte. Además, se constata que las informaciones deportivas son en su amplia mayoría masculinas y locales.
KAPPADOKİA’NIN İKLİM YAPISININ BÖLGENİN SOSYO-EKONOMİK YAPISINA ETKİSİ
Authors: Atcı Esra
Published: December 2024

Bugün Anadolu bozkırlarının büyük bir bölümünü kapsayan Kappadokia Bölgesi antik çağlarda da iklimsel olarak günümüzdekiyle benzer niteliklere sahip olmuştur. Bu durum bölgede yaşayan halkın ekonomik faaliyetlerini doğrudan etkilemiş ve bölge halkı iklimin getiridiği çevresel şartlara bağlı bir yaşantı sürmüştür. Bu nedenle yüz ölçümü bakımından oldukça geniş bir alana yayılan bölgede karasal iklimin belirlediği koşullarda temel geçim kaynaklarını tarım ve ağırlıklı olarak küçükbaş hayvancılık oluşturmuştur. Bununla birlikte bölge yazılı kayıtlara göre Asur Ticaret Kolonileri Çağı’ndan, Roma döneminin sonuna kadar atları ve at yetiştiriciliği ün sağlamış ve buradan gelir elde etmiştir. Katır ve Kappadokia yaban eşekleri daha çok antik çağda şöhrete kavuşmuş hatta katırlar batıdaki pazaralarda at niyetine satılmıştır. Buna karşılık yine iklimsel şartlar nedeniyle bölgenin doğu ve batısında yetiştirilen ürünlerin oranı ve çeşitliliği konusunda farklılıklar mevcuttur. Buna göre batıda karasal iklimin en yoğun hissedildiği alanda buğday, arpa ve üzüm temel tarımsal ürünler olurken, bölgenin doğu kesiminde yer alan Melitene’de zeytin ve antik çağda oldukça ünlü olan Monarite şarabının hammaddesi olan kaliteli üzüm yetiştirilmiştir. Melitene’de zeytin yetiştirilmesi bölgenin mikro klima özelliği göstermesiyle yakından ilişkilidir.
Bu çalışmada Kappadokia Bölgesi’nin iklim yapısının bölgenin sosyo-ekonomik yapısına etkileri incelenmiştir.
Effect of Gynura procumbens (Lour.) Merr. on the histopathology of the diabetic pancreas via caspase family expression
Authors: Situmorang Putri Cahaya , Dewatisari Whika Febria , Setyawati Andina , Manurung Risma Dumiri , Setiawan Eka
Published: December 2024

Context: Diabetes is a prominent cause of mortality globally, particularly in Indonesia. Elevated glucose levels stimulate insulin secretion from pancreatic β cells. A variety of drugs, including oral treatments and synthetic insulin, have been developed to address the needs of individuals with diabetes mellitus. Nevertheless, these medications are often too expensive. Gynura procumbens, a plant prevalent in Indonesia, demonstrates notable antidiabetic potential.
Aims: To analyze apoptosis via caspase family in pancreas tissue after administration of G. procumbens.
Methods: The ethanol extract of G. procumbens leaves was chitosan nanoencapsulated by amalgamating chitosan with a glacial acetic acid solution, followed by filtration with Na-TPP solution. This study utilized Wistar rats divided into six groups, comprising two control groups, one comparison group receiving metformin, and three treatment groups administered G. procumbens at doses of 100, 200, and 300 mg/kg BW orally for two weeks. The rats underwent dissection for immunohistochemistry examination of caspase family proteins.
Results: Administering G. procumbens leaves to rats in the diabetic cohort markedly reduced blood glucose levels, particularly in the P3. The glucose levels in this cohort were nearly equivalent to those observed in the group receiving the metformin. The injection of the maximum dosage of G. procumbens at 300 mg/kg BW can inhibit apoptosis via caspase-3, -8, and -9. Furthermore, it can regenerate pancreatic tissue by mitigating necrosis and vacuolization.
Conclusions: G. procumbens inhibits apoptosis by decreasing the expression of the caspase family in the pancreatic tissue of diabetic rats.
BÁO CÁO CA LÂM SÀNG: UNG THƯ BIỂU MÔ ĐƯỜNG NIỆU TRÊN Ở BỆNH NHÂN SỎI THẬN CÙNG BÊN
Authors: Đào Văn Nhật , Nguyễn Đình Dương , Nguyễn Xuân Khái , Nguyễn Phú Việt
Published: December 2024

Ung thư biểu mô đường niệu trên (UTBMĐNT) là loại ung thư hiếm gặp trong tiết niệu. Nguyên nhân gây bệnh còn chưa rõ ràng, sỏi tiết niệu được chỉ ra là một trong các yếu tố nguy cơ thúc đẩy sự hình thành của các bệnh lý này. Chẩn đoán UTBMĐNT ở bệnh nhân (BN) có sỏi thận cùng bên thường gặp khó khăn do các triệu chứng lâm sàng và cận lâm sàng của ung thư thường bị che lấp bởi các triệu chứng do sỏi gây nên. Chúng tôi trình bày 2 trường hợp mắc UTBMĐNT ở BN có sỏi thận cùng bên để bàn luận thêm về cách thức chẩn đoán và phương pháp điều trị bệnh lý này. 2 trường hợp này đều có các đặc điểm nghi ngờ ung thư trên phim chụp cắt lớp vi tính (CLVT) tiêm thuốc và được chẩn đoán xác định trong quá trình mổ mở lấy sỏi.
NGHIÊN CỨU HIỆU QUẢ ĐIỀU TRỊ HỖ TRỢ LIỆT DÂY THẦN KINH VII NGOẠI BIÊN DO LẠNH BẰNG PHƯƠNG PHÁP HÀO CHÂM KẾT HỢP VỚI CHIẾU ĐÈN HỒNG NGOẠI
Authors: Nguyễn Trâm Anh , Đậu Hữu Nghị
Published: December 2024

Mục tiêu: Đánh giá tác dụng của hào châm kết hợp với chiếu đèn hồng ngoại điều trị liệt dây thần kinh VII ngoại biên do lạnh. Phương pháp nghiên cứu: Nghiên cứu tiến cứu, can thiệp, so sánh trước và sau điều trị trên 30 bệnh nhân (BN) được chẩn đoán xác định liệt dây thần kinh VII ngoại biên do lạnh tại Bộ môn - Khoa Y học cổ truyền, Bệnh viện Quân y 103 từ tháng 6/2023 - 6/2024. Kết quả: Sau 14 ngày điều trị, có 18 BN khỏi bệnh hoàn toàn (60,0%), 16,7% BN cải thiện tốt. Kết luận: Hào châm kết hợp với chiếu đèn hồng ngoại có hiệu quả tốt và an toàn trên BN liệt dây thần kinh VII ngoại biên do lạnh.
ĐÁNH GIÁ HIỆU QUẢ CỦA LỌC MÁU LIÊN TỤC BẰNG MÀNG LỌC HẤP PHỤ TRONG ĐIỀU TRỊ SỐC NHIỄM KHUẨN TRÊN BỆNH NHÂN BỎNG NẶNG
Authors: Ngô Tuấn Hưng , Nguyễn Như Lâm , Nguyễn Hải An , Trần Đình Hùng
Published: December 2024

Mục tiêu: Đánh giá hiệu quả của phương pháp lọc máu liên tục (LMLT) bằng màng lọc hấp phụ (hemofiltration - HFA) trong điều trị sốc nhiễm khuẩn (SNK) trên bệnh nhân (BN) bỏng nặng. Phương pháp nghiên cứu: Nghiên cứu tiến cứu, can thiệp trên 55 đợt SNK ở 38 BN bỏng nặng (16 - 60 tuổi) được LMLT bằng màng lọc hấp phụ (màng oXiris), điều trị tại Khoa Hồi sức Cấp cứu (HSCC), Bệnh viện Bỏng Quốc gia Lê Hữu Trác từ tháng 01/2023 - 6/2024. Các thời điểm nghiên cứu: Lúc chẩn đoán SNK (T1), thời điểm LMLT (T2), sau 6 giờ LMLT (T3), 12 giờ LMLT (T4), 24 giờ LMLT (T5) và 48 giờ LMLT (T6). Kết quả: Tỷ lệ tử vong là 60,53%. Trong 55 đợt SNK có 36 đợt thoát sốc (65,45%). Trong quá trình LMLT, điểm SOFA (T2: 8 (7 - 9), T4: 7 (6 - 8), T5: 6 (5 - 8), T6: 5 (2 - 8), p < 0,001), thang điểm trợ tim - vận mạch (VIS) (T2: 30 (20 - 50), T3: 20 (15 - 40), T4: 15 (10 - 30), T5: 5 (3 - 30), T6: 0 (0 - 20), p < 0,001) và nồng độ lactate máu động mạch (T1: 2,6 (2,3 - 3,4) mmol/L, T3: 1,9 (1,3 - 2,6) mmol/L, T4: 1,9 (1,2 - 2,4) mmol/L, T5: 1,8 (1,3 - 2,5) mmol/L, T6: 1,8 (1,3 - 2,5) mmol/L, p < 0,001) giảm có ý nghĩa. Kết luận: LMLT bằng màng lọc hấp phụ làm giảm có ý nghĩa điểm SOFA, VIS và nồng độ lactate máu. Tỷ lệ tử vong ở BN bỏng có SNK là 60,53%.
Fenomena Sosial Sumbangan Pembangunan Masjid di jalan raya (Studi Kasus Kecamatan Bintan Timur, Kabupaten Bintan)
Authors: Pepriyana Adiya , Mita Mita , Setiandika Igasi Teguh
Published: December 2024

The phenomenon of asking for alms on the road for religious needs is one that is currently happening, but the phenomenon of asking for alms on the main road is certainly not only felt by Muslims, because people of other religions or non-Muslims also feel it because they are also users of the road. . thus causing discomfort for road users. The aim of this research is to find out the phenomenon of donations on this road according to the sociology of religion. The method used is incidental sampling which is a data collection technique by finding respondents by chance in one place without planning. The finding in this research is that each mosque has its own way of seeking funds for the renovation of its mosque, and these actions can be analyzed using Max Weber's theory of social action.
INSTRUÇÃO ENTRE PARES NO ENSINO SUPERIOR
Authors: Trindade Cícero da
Published: December 2024

Este artigo avalia as potencialidades da “Instrução entre Pares” (IP) no ensino superior em aulas presenciais e online, bem como examina as estratégias de aplicação, os impactos na participação e compreensão dos alunos, e os desafios enfrentados pelos professores ao integrar essa metodologia em suas práticas pedagógicas. Fundamentado principalmente nos estudos de Ferreira e Kempner-Moreira (2017), Cavaignac, Gouveia e Reis (2020), e Pinto et al. (2012), por meio de revisão bibliográfica, a pesquisa analisa diversos aspectos desse processo centrado em pares. Os resultados evidenciam como a IP desenvolve habilidades como pensamento crítico, liderança e comunicação, além de ressaltar a necessidade de formação docente contínua e adaptação aos recursos digitais. O estudo demonstra que essa proposta facilita a interação e colaboração entre alunos, fortalecendo o engajamento e a aprendizagem ativa. Também se destaca a relevância das Tecnologias da Informação e Comunicação (TICs) na aplicação dessa dinâmica, indicando como essas ferramentas podem aprimorar a prática pedagógica. Recomenda-se que futuras pesquisas examinem com maior profundidade as estratégias de adoção da IP com apoio de TICs, especialmente em aulas online, bem como realizem análises comparativas entre diferentes contextos culturais e institucionais para identificar práticas exitosas de implementação dessa metodologia em diversos cenários educacionais.
“Spanish Trace” in the Plot, Libretto, and Stage Performances of Beethoven’s Opera Fidelio
Authors:   Moscow State Tchaikovsky Conservatory, Kirillina Larisa V. ,   State Institute for Art Studies
Published: December 2024

The article considers the various connections between Ludwig van Beethoven’s opera Fidelio and specific elements pertaining to Spanish culture. According to the libretto, the events take place in a state prison near Seville. Beethoven’s librettists (Joseph Sonnleithner, Stephan von Breuning and Georg Friedrich Treitschke) closely followed the original source, Jean-Nicolas Bouilly’s play Léonore, ou L’amour conjugal, which had originally been set to music by Pierre Gaveaux (Paris, 1798). If Bouilly’s play is designated as a “historical fact” (fait historique), then on the title page of Gaveaux’ opera there appeared a further clarification: “a fact from Spanish history” (fait historique Espagnol). It is traditionally believed that the choice of Spain as the setting for both the French original and the German adaptations of the libretto was based on censorship considerations. Indeed, Bouilly had good reasons not to advertise any connection between the plot of Léonore and the events of the Jacobin Terror of 1793. However, the “Spanish trace” is still present in Bouilly’s play and in the libretto of Fidelio. The plot of Bouilly’s Léonore might contain references to the medieval legend of the 10th century Count Fernán González, who, according to the epic poem composed three centuries later, was freed from captivity by his bride, the Infanta Sancha. Several books on this topic published in Spain during the 18th century were accompanied by illustrations reminiscent of the mise-en-scènes from the prison scene in Fidelio. The “Spanish trace” is visible both in the names and in the characters of the opera’s heroes, especially Léonore, Pizarro and Florestan (in some 19th-century adaptations of Fidelio, Florestan was given either a Spanish aristocratic surname or the name Ferdinando). The staging and costumes for Beethoven’s opera also contained features that clearly indicated the era of the late 16th–early 17th century, i.e., the time of the reigns of Philip II and Philip III. Although Fidelio was not staged in Spain until 1893, this opera became a repertoire piece in Spanish-speaking countries in the 20th and 21st centuries.
Georges Bizet in the Service of the Opera: More than “Just” a Composer?
Authors:   Gnesin Russian Academy of Music, Zakharbekova Irina S.
Published: December 2024

Georges Bizet occupies an important place in the history of French musical theatre thanks to his works such as Carmen and Les pêcheurs de perles. However, the musical career of this bright and original composer includes not only his own compositional oeuvre, which is relatively modest in terms of the number of works he created, but also his work in adjacent spheres. The article discusses the editorial and correction work on the works of other authors, which Bizet began to carry out in the mid-1850s and was especially active in the 1860s and early 1870s. Bizet worked on transcriptions (piano-vocal reductions, arrangements for solo piano and duets for 4 hands, orchestration and additional compositions) of opera works by other composers for French music publishing houses — primarily Choudens and Heugel. The article also examines Bizet’s participation in the rehearsal and production process of opera performances by his colleagues and friends — in particular, Charles Gounod and Ernest Reyer. By turning to the composer’s epistolary legacy and the memoirs of his contemporaries, as well as by analysing some of the available operatic arrangements made by Bizet, we gain the opportunity to take a closer look at French musical and theatrical life of the second half of the 19th century as well as the private work of a musician of that time: work that was not always socially or legally recognised, but which nevertheless demonstrated the quality and professionalism of its producer. Moreover, a discussion of Bizet’s piano arrangements is important both in the context of the existence of this kind of music, as well as from the point of view of the educational and development functions that it fulfilled. No less significant for Bizet’s career was his assistance and participation in rehearsals of his compatriots’ performances in Parisian and other theatres: acting as an accompanist and “assistant composer”, Bizet could observe the opera “kitchen” from the inside and thus avail himself of the opportunity to prepare the ingredients for his own musical and theatrical masterpieces.
Panorama of 20th Century Opera: from the History of One Cycle of the Main Editorial Board of Music Broadcasting of the All-Union Radio
Authors:   Dmitri Hvorostovsky Siberian State Academy of Arts, Gavrilova Lyudmila V.
Published: December 2024

The article examines a cycle of programs of the Main Editorial Board of Musical Broadcasting of the All-Union Radio, Panorama of 20th Century Opera. Due to a happy accident, the author came into the possession of seven volumes of typescript texts of 96 radio programs, which were subject to depreciation and destruction, due to the expired time-limit of storage. The first was dated January 8, 1968 года, whereas the last went on the air on October 1, 1971. Over a hundred works by composers from Russia and other countries were broadcast during the four seasons of the cycle. These composers included Giacomo Puccini, Richard Strauss, Arnold Schoenberg, Igor Stravinsky, Nikolai Rimsky-Korsakov, Dmitri Shostakovich, Sergei Prokofiev, Gheorghe Enescu, Leos Janacek, Zoltan Kodaly, Paul Dessau, Eugen Suchon, Sandor Szokolay and others. The operas were broadcast in their entirety, their synopses were expounded before each act, as the result of which the time duration relayed for the broadcast ranged up to four hours over the airwaves. Of special attention were the introductory words devoted to the composer’s personality and music, the history of the opera’s creation and the performances, which could range up to 50 minutes. All the significant researchers of musical theater of that time were engaged into the project. A great role was played by Boris Yarustovsky: his introduction to the cycle of radio programs about the paths of development of the opera genre is directly connected with the monograph Ocherki po dramaturgii opery ХХ veka [Essays on Dramatic Concept of Twentieth-Century Opera], the first part of which was published later, in 1971. Besides that, the programs involved the participation of Leo Mazel, Boris Levik, Lev Danilevich, Gigoriy Schneerson, Israil Nestyev, Marina Sabinina, Larisa Danko, Oksana Leontyeva, Ludmila Polyakova and others. Special attention is merited by the original lectures of Gennady Rozhdestvensky devoted to one-act operas by composers outside of Russia and Igor Stravinsky, as well as an overview of Soviet opera, with accentuation of its most important features undertaken in one of the programs by Innokenty Popov, the assistant editor of the newspaper Sovetskaya kul’tura [Soviet Culture]. The author of the article arrives at the conclusion that in the cycle Panorama of 20th Century Opera at the All-Union Radio for the first time in Russian musicology a detailed, academically equipped retrospective review of opera of the first six decades of the 20th century, while the preserved texts merit being published in a separate edition.
Michael Nyman’s Opera Noises, Sounds and Sweet Airs and Questions of Interpretation of Shakespeare’s The Tempest
Authors:   Petrozavodsk State A. K. Glazunov Conservatory, Okuneva Ekaterina G. , Nogovitsyna Anastasiya A.
Published: December 2024

The article focuses on the interpretation of the themes and images of Shakespeare’s The Tempest in Michael Nyman’s opera Noises, Sounds and Sweet Airs. The authors touch upon the issues of the history of the creation of the work, the features of the libretto, which acquired the character of an intermittent narrative as a result of the radical reduction of the original source, and examine the compositional and dramatic patterns of the opera and its musical and stylistic specificities. In his interpretation, Nyman combines the traditional view of Shakespeare’s play as a metaphor for artistic creativity with its postcolonial reading. Compositional strategies are based on deconstruction techniques, manifested in depersonalization (the separation of voices from the roles, leading to a subtraction of the theatrical-stage component), the semantic gap between the text and the music, self-reference, and harmonic similarity, which makes it possible to establish a commonality between characters that are essentially opposite (Caliban and Prospero), which contributes to a re-evaluation of the perception of their images.
HATAY İSKENDERUN BÖLGESİNDE TÜRBELER VE İŞLEVLERİ
Authors: Gül İnci , Arı Bülent
Published: December 2024

Hatay’ın çok kültürlü bir yapısı mevcuttur ve bu mevcudiyet doğrultusunda bu bölgede çeşitli inanç ve ritüeller bulunmaktadır. Bu makalede bölge insanlarının inançsal faaliyetlerinden biri olan türbe ziyaretleri incelenmiş, türbelere gitme sebepleri, bu kutsal mekânların kerametleri, halk arasında dilden dile aktarılan rivayetler kayda geçirilmiştir. Bu bağlamda İskenderun ve bölgesinde yaşayan insanların yaptığı türbe ziyaretleri, eylem ve ritüellerinin manaları incelenmiş ve anlamlarına ulaşılmaya çalışılmıştır. İskenderun’daki Şıh Muhammed el Kerim Türbesi ve Serinyol’daki ismi olmayan, Seyd el Hıdır, Seydne Şıh Hasan, Seydne Şıh Musa ve Şıh Yusuf el Hakim’in ortak buluşma noktası olduğuna inanılan türbe, havaalanı yapımına mani olduğuna inanılan Şıh Hıdır Aleyhisselam Türbesi ve bu türbelerde ritüelleşen eylemlerin bölge halkının kültürüne yansıması incelenmiştir. Bu çalışma, Hatay bölgesinde yaşatılan evliya kültlerinden olan türbe inançlarının, insanların yaşantılarında nasıl devam ettirildiği konusunu ele almış ve çalışmada önemli üç türbenin hayatlardaki yerleri, bu türbelere dair inançlar, Türk kültüründe var olan atalar kültünün İslamiyet etkisiyle birlikte evliya kültüne dönüştüğü ve bu bölgede, ölmüş ataların ruhları için yapılan eylemler aktarılmıştır.
POTENSI PEWARNAAN ALAMI EKSTRAK BUAH NAGA MERAH Hylocereus polyrhizus SEBAGAI ALTERNATIF EOSIN
Authors: Sabban Indra Fauzi , Wahyuni Ismiy Noer
Published: December 2024

Proses pewarnaan rutin yang sering digunakan diseluruh laboratorium patologi anatomi dalam pembuatan sediaan sitologi yaitu Papanicolaou dan Diff Quick. Metode pengecatan rutin tersebut dapat menghasilkan gambaran mikroskopik yang menghasilkan hasil yang berbeda-beda, namun bahan yang digunakan dalam pewarnaan tersebut kebanyakan bersifat karsinogenik. Dalam jangka Panjang dapat mempengaruhi petugas yang melakukan proses pewarnaan. Maka dari itu, penelitian ini memiliki Tujuan jangka pendek adalah untuk melihat perbedaan kualitas warna dalam pengecatan sediaan Fine Needle Aspiration Biopsy (FNAB) untuk pemeriksaan kanker payudara yang dibandingkan dengan pewarnaan alami ekstrak buah naga, sedangkan tujuan jangka panjangnya untuk menemukan metode pewarnaan alternatif yang dapat digunakan untuk sampel FNAB payudara yang lebih ramah terhadap lingkungan. Metode penelitian ini adalah metode eksperimen dengan melakukan perbandingan pada 3 jenis pewarnaan. Hasil penelitian menunjukan potensi yang dimiliki oleh ekstrak buah naga merah sebagai alternatif pengganti eosin. Kesimpulan dari penelitian ini adalah ekstrak buah naga merah memiliki potensi sebagai pewarnaan alami sediaan selular.
IDENTIFIKASI SENYAWA FITOKIMIA EKSTRAK ETANOL 70% AKAR GINSENG KUNING (RENNELLIA ELLIPTICA KORTH.) MENGGUNAKAN LC-MS/MS DAN AKTIVITAS AFRODISIAKA SECARA IN SILICO
Authors: Istiqamah Farida , Sukardiman Sukardiman , Widyowati Retno
Published: December 2024

Abstrak
Latar belakang: Rennellia elliptica Korth. secara tradisional digunakan sebagai zat afrodisiak. Dilihat dari potensinya, bukti ilmiah ekstrak tumbuhan ini sebagai penghambat phosphodiesterase-5 masih belum dilakukan Tujuan: Penelitian ini bertujuan untuk mengetahui senyawa fitokimia yang terdapat pada ekstrak etanol 70% tanaman rennellia elliptica Korth. menggunakan LC-MS/MS dan aktivitas afrodisiakan secara in silico. Metode: Ekstrak etanol rennellia elliptica Korth. dianalisis menggunakan LC-MS/MS selanjutnya senyawa tersebut digunakan sebagai senyawa ligan dalam penambatan molekuler untuk mengetahui afinitas pengikatan konstituen fitokimia tersebut terhadap protein target phosphodiesterase 5 (PDB ID: 2H42). Hasil: Ditemukan 17 komponen senyawa antara lain golongan terpenoid, fenilpropanoid, antrakuinon dan flavonoid. Berdasarkan studi in silico dari 17 senyawa yang dianalisis dengan LC-MS/MS, Dulxanthone B (∆G=-9,52 kkal/mol) menunjukkan afinitas tertinggi untuk berikatan dengan target protein. Simpulan: Senyawa fitokimia dari rennellia elliptica Korth. dapat berfungsi sebagai terapi tambahan dalam penemuan obat untuk pengobatan yang menghambat phosphodiesterase 5.

Abstract
Background: Rennellia elliptica Korth. is traditionally used as an aphrodisiac substance. Judging from its potential, scientific evidence of this plant extract as a phosphodiesterase-5 inhibitor has yet to be conducted. Objective: . This research aims to determine the phytochemical compounds contained in the 70% ethanol extract of the Rennellia elliptica Korth plant. using LC-MS/MS. Method: The ethanol extract of rennellia elliptica Korth. was analyzed using LC-MS/MS and then the compounds were used as ligand compounds in molecular docking to determine the binding affinity of the phytochemical constituents to the target protein phosphodiesterase 5 (PDB ID: 2H42). Results: 17 compound components were found, including terpenoids, phenylpropanoids, anthraquinones and flavonoids. Based on in silico studies of 17 compounds analyzed by LC-MS/MS, Dulxanthone B (∆G=-9.52 kcal/mol) showed the highest affinity for binding to protein targets.. Conclusions: Phytochemical compounds from Rennellia elliptica Korth. may serve as an adjunct therapy in drug discovery for treatment that inhibits phosphodiesterase 5.
ANALISIS EFEKTIVITAS PENGGUNAAN BREAST BOARD PADA VENA CAVA SUPERIOR SYNDROME (VCSS) DENGAN TEKNIK THREE DIMENSIONAL CONFORMAL RADIATION THERAPY (3D-CRT)
Authors: Maritza Adelia Nursri , Anwar Khairil
Published: December 2024

Latar belakang Kasus karsinoma paru di Instalasi Onkologi Radiasi Rumah sakit X Jakarta Timur biasanya dilakukan dengan teknik radioterapi three dimensional conformal radiation therapy (3D-CRT) atau teknik IMRT dan menggunakan body base plate serta masker thermoplastik. Pasien karsinoma paru dengan vena cava superior syndrome (VCSS) dilakukan teknik 3D-CRT dengan alat imobilisasi berupa breast board. Alat imobilisasi breast board biasanya digunakan untuk pasien dengan kasus kanker payudara, namun di Rumah sakit X Jakarta Timur alat imobilisasi ini dimanfaatkan untuk pasien VCSS yang tidak dapat berbaring penuh dengan tujuan mengurangi rasa sesak pasien.VCSS merupakan kumpulan gejala yang terjadi akibat adanya penekanan vena cava superior oleh tumor mediastinum yang bersifat ganas maupun jinak.
Tujuan Penelitian menjelaskan teknik 3D-CRT pada kasus VCSS menggunakan breast board di instalasi onkologi radiasi Rumah sakit X Jakarta Timur.
Metode Penelitian kualitatif yang dilakukan untuk mendeskripsikan terapi radiasi dengan teknik 3D-CRT pada kasus VCSS yang menggunakan Breast board di Instalasi Onkologi Radiasi Rumah sakit X Jakarta Timur. Penelitian ini dilakukan pada bulan Mei-Juni 2024 di Instalasi Onkologi Radiasi Rumah sakit X Jakarta Timur. Penelitian ini menggunakan data primer yang dikumpulkan dengan cara observasi, wawancara, dan dokumentasi. Instrumen yang digunakan pada penelitian ini adalah pesawat LINAC, EPID, komputer TPS, Data set up pasien CT simulator, Breast board, Lembar Observasi, Lembar Pedoman wawancara dan Hasil dokumentasi. Data-data hasil pengumpulan data akan dianalisa secara kualitatif dan disajikan dalam bentuk uraian naratif.
Hasil Penelitian prosedur terapi radiasi teknik 3D-CRT pada VCSS dengan menggunakan alat imobilisasi breast board sudah sesuai dengan SPO yang berlaku di rumah sakit. Rata-rata pergeseran titik koordinat x sebesar 0,4 cm, titik koordinat y sebesar 0,4 cm, titik koordinat z sebesar 0,0 cm sehingga hal ini sudah sesuai dengan rekomendasi ICRU report 50 dan 62 yakni toleransi nilai pergeseran sebesar 3-5 mm.
Simpulan penggunaan breast board dinilai efektif dilakukan untuk mengurangi rasa sesak pasien dan meminimalisir pergeseran pasien saat pernyinaran radiasi.
SCREENING OF SECONDARY METABOLITE COMPOUNDS AND YIELD OF WHITE RHIZOME (Alpinia Galanga L.) EXTRACT THROUGH FOUR EXTRACTION METHODS
Authors: Badriyah Lailatul
Published: December 2024

Background: Health maintenance can be addressed by the utilization of natural medicines derived from plants called traditional medicine. Traditional medicine can be produced from rhizomes, one of include was the white galangal rhizome. The chemical compounds of white galangal rhizome provide numerous benefits in both culinary and health fields. Objective: to obtain the best yield from the four extraction methods used. The extracts obtained were tested qualitatively using chemical reagents. Method: The method employed was a laboratory experiment utilizing various extraction techniques. The results indicate that the yields from maceration, soxhletation, reflux, and infusion were 11.955%, 20.359%, 15.737%, and 9.416%, respectively. The secondary metabolite compounds found in the white galangal rhizome extract were flavonoids, alkaloids, tannins, terpenoids, and saponins. Conclusions: it can be concluded that the extraction method with the best yield results was the soxhletation method.
El impacto de la corrupción en la sociedad y la economía de la administración pública en Ecuador
Authors: Santos Alava Jose Eduardo , Albarez Navarro Gabriela Heidy , Boza Valle Jhon Alejandro , Chang Rizo Fresia Susana
Published: December 2024

En Ecuador la corrupción es un tema sumamente delicado ya que en base a este nace de la ineficiencia de la administración pública por reducir este problema social, si bien la corrupción siempre ha estado presente en el país, en los últimos años ha experimentado un aumento significativo en su visibilidad y repercusión, ya que no solo afecta al rendimiento económico del país como tal, genera una desconfianza por parte de la sociedad al ser testigo que la mayor parte de los licitantes a este delitos son los mismos entes reguladores, convirtiendo al país cada vez menos atractivo a la inversión extranjera y a generar mayores valores a pagar por la ineficiencia del pago de la deuda externa generando un impacto negativo en las operaciones crediticias del país, por lo que en base a la necesidad de conocer el desenvolvimiento de la corrupción en los últimos año, este articulo nos permitirá tener una perspectiva mucho más amplia del impacto de este problema social en el desarrollo económico del país y la administración pública, ya que afecta también sectores como el empleo, educación, salud y sectores impulsores del crecimiento económicos.
Impacto de la violencia política electoral en la participación y seguridad de los actores políticos: un análisis de homicidios, coacción electoral y conflictos en campañas en México
Authors: Carvajal Larios Ana Lilia , Carvajal Larios Liliana , Briones Montiel Judith
Published: December 2024

La violencia política electoral en México ha crecido significativamente en los últimos años, alterando la dinámica electoral y poniendo en riesgo la seguridad de actores políticos, votantes y funcionarios electorales. Este ensayo aborda cuatro aspectos cruciales para entender el impacto de este fenómeno: los homicidios y atentados contra actores políticos, las denuncias por coacción o intimidación electoral, la tasa de participación electoral en contextos de violencia y los incidentes violentos durante las campañas electorales. El análisis de homicidios y atentados resalta la vulnerabilidad de los actores políticos y el impacto directo en la seguridad del proceso electoral. Las denuncias por coacción e intimidación electoral demuestran que la violencia no solo afecta de manera física, sino que también limita la libertad de elección de los votantes, al correlacionar la violencia con la participación electoral, pues a partir de ello se observa cómo la inseguridad desincentiva el voto y afecta la legitimidad de las elecciones. Asimismo, los incidentes violentos durante las campañas son reflejo de un clima de polarización y caos que compromete el libre ejercicio de los derechos políticos. Por tanto, este análisis busca contribuir a la comprensión de la evolución de la violencia política electoral y su vínculo con la delincuencia organizada, proponiendo la comprensión fáctica de su impacto para coadyuvar en el desarrollo de políticas públicas que fortalezcan la seguridad y la legitimidad de los procesos electorales en México.
EIPT: Innovación Tecnológica y Ética para la Transformación de la Educación Inclusiva
Authors: Gayosso Mexia Sonia , Servín Gómez Alejandro , Hernández García Luz María de la Paz , González Granados J. Gersain
Published: December 2024

La inclusión educativa busca garantizar el aprendizaje equitativo para todos los estudiantes, independientemente de sus capacidades, en entornos que valoren la diversidad. Esta investigación examina cómo la Inteligencia Artificial (IA) y otras tecnologías avanzadas pueden transformar la educación inclusiva. Se desarrolló el modelo conceptual Educación Inclusiva Potenciada por Tecnología (EIPT), que integra tecnologías avanzadas, principios pedagógicos inclusivos y consideraciones éticas. Los casos de estudio en Ecuador y México destacaron la capacidad de las herramientas de IA para personalizar el aprendizaje, mejorar la accesibilidad y fomentar la participación estudiantil. En Ecuador, el 85% de los estudiantes con discapacidades experimentó avances gracias a sistemas adaptativos de IA, mientras que en México, la participación aumentó un 60% en entornos colaborativos apoyados por IA. Sin embargo, persisten desafíos como la falta de infraestructura tecnológica, la resistencia docente a nuevas tecnologías y los riesgos éticos, como la privacidad de datos y los sesgos algorítmicos. Se concluye que la IA tiene el potencial de transformar la educación inclusiva, pero su implementación debe ser ética, responsable y adaptada a contextos específicos. Este estudio ofrece una hoja de ruta para aprovechar las tecnologías emergentes en la inclusión educativa, destacando la importancia de la formación docente, la colaboración intersectorial y un enfoque centrado en el usuario.
La Planificación Estratégica y el acceso a financiamiento como factores críticos para el emprendimiento de los graduados de la universidad Católica de Cuenca
Authors: Ortiz Gonzalez Raul Adrian
Published: December 2024

El Objetivo de este trabajo de investigación se centra en determinar si la Planificación Estratégica y el acceso a financiamiento son factores determinantes al momento de emprender entre los graduados de la Universidad Católica de Cuenca (UCACUE), en los años 2018 a 2023, específicamente en la provincia del Cañar que cuenta con extensiones en la Ciudad de La Troncal y Cañar, así como una Sede en la ciudad de Azogues. Se destaca la relevancia del emprendimiento como motor de desarrollo económico y la importancia de la educación superior en fortalecerlo. Entre los principales hallazgos se pudo evidenciar que los emprendedores provienen mayormente de la Extensión de La Troncal, los negocios son relativamente pequeños, con un enfoque predominante en el comercio. Utilizando el análisis de la Regresión Lineal Múltiple el estudio demuestra que la Planificación Estratégica es un factor clave para el éxito empresarial no así el acceso a financiamiento. Atributos, adquiridos a través de la formación universitaria y la experiencia práctica, permiten a los emprendedores identificar oportunidades, desarrollar ideas innovadoras y gestionar sus negocios de manera efectiva. Con base a los resultados de esta investigación las entidades provinciales y cantonales podrían adoptar programas de acompañamiento a través de capacitaciones y actualizaciones profesionales al emprendedor desde la apertura de sus negocios hasta su sostenibilidad en el tiempo. De igual manera este trabajo podría sugerir a las Instituciones de Educación Superior (IES) del país a mantener actualizado el pensum académico teniendo en cuenta los aspectos locales y coyunturales del ecosistema empresarial conjuntamente con las nuevas tecnologías
Experiencias y Testimonios de la Comunidad Educativa sobre el Codiseño Curricular
Authors: Cauich Uicab Manuelita Concepción , Paredes Reyes Marisol de Jesús , Reyes Pinzón María Eliud , Pérez Rosado Sonia Mariana
Published: December 2024

En esta artículo[1] se analizarán las experiencias y testimonios de la comunidad educativa respecto al codiseño curricular en el contexto del Normalismo Mexicano. El enfoque participativo del codiseño curricular permite la inclusión de las voces de docentes, estudiantes, miembros de la comunidad en el desarrollo del currículo. A través de estudios de entrevistas, se explorarán los beneficios, desafíos y percepciones de los diferentes actores involucrados. Los resultados destacan la mejora en la relevancia educativa, el sentido de pertenencia y la motivación estudiantil, al tiempo que identifican áreas para fortalecer la formación docente y la participación comunitaria.
 
[1] Este artículo fue presentado como una ponencia
Algebraic method for image reconstruction in ultrasonic tomography
Authors: Nguyen The-Lam , Tran Quang-Huy
Published: December 2024

Ultrasound tomography is crucial due to its capability to deliver detailed, real-time, and non-invasive imaging. This is essential for early diagnosis, treatment planning, and guiding medical procedures. Its affordability, portability, and safety make it a versatile tool in medical and non-medical fields alike, driving ongoing advancements in technology and applications. The Distorted Born Iterative Method (DBIM) is an advanced technique used in ultrasound tomography to iteratively restore images, improving upon the standard Born approximation by addressing some of its limitations. However, the DBIM also has its own set of disadvantages when used for iterative image restoration, resulting in computational complexity, noise sensitivity, convergence issues, etc. In this paper, we introduce a new method for image reconstruction in ultrasound tomography by using the algebraic method. The numerical results indicate that this method has a shorter computational time and achieves high-resolution reconstructions and accurate solutions.
Effect of Rotation Speed and Feed on the Surface of ST 41 Steel on a Lathe Machine
Authors: Akhmadi Amin Nur , Usman Mukhamad Khumaidi , Sanjaya Firman Lukman
Published: December 2024

This study discusses the effect of feed rate and machine rotation speed on the surface roughness of ST 41 steel in the flat turning process. The aim is to determine the relationship between variations in rotation speed (100 rpm, 300 rpm, and 500 rpm) and feed rate on the final surface results of the workpiece. The method involves cutting tests on ST 41 steel specimens with a diameter of 25 mm and a length of 400 mm with various rotation speed variations. The results show that at low rotation speed (100 rpm), the surface of the workpiece tends to be rough. The surface becomes better at medium speed (300 rpm), while at high speed (500 rpm), the surface results are smoother. These findings indicate that increasing rotation speed contributes to a decrease in surface roughness. Thus, higher rotation speeds can improve the quality of turning results.
Perancangan Mesin Hot Press Untuk Pengolahan Limbah Sampah Plastik Menjadi Produk Plastic Sheet
Authors: Simangunsong Helfran , Hermanto Tino , Purba Tiochanra
Published: December 2024

Limbah sampah plastik merupakan isu penting yang mendasari perancangan mesin hot press. Penelitian ini bertujuan untuk merancang mesin hot press yang mampu mengelola limbah sampah plastik menjadi produk plastic sheet serta mengevaluasi aspek keamanan dan keselamatan kerja dalam pengoperasiannya. Metode yang digunakan adalah perancangan berbasis perangkat lunak SolidWorks dengan teknik pengumpulan data rancangan. Hasil penelitian menunjukkan bahwa (1) kapasitas beban kritis besi hollow mencapai 4019,23 kN, (2) tekanan pegas sebesar 100.000 Pa, (3) tekanan dongkrak sebesar 5,3 MPa, (4) konsumsi daya listrik mesin hot press adalah 2,22 kW, dan (5) daya listrik untuk 10 pemanas cartridge sebesar 1.472,42 Watt. Tekanan cetakan sebesar 2,20 kN dengan luas area 4,16 cm², ketebalan plastic sheet 10 mm, dan kerapatan mencapai 950 kg/m³. Kesimpulannya, dimensi rangka mesin adalah 600 mm x 600 mm x 1200 mm menggunakan besi hollow 40 mm x 40 mm. Evaluasi keselamatan kerja menekankan pentingnya penggunaan alat pelindung diri (APD), kepatuhan terhadap prosedur pengoperasian, dan kesiapan menghadapi keadaan darurat.
Predicción de la fertilidad del suelo mediante aprendizaje automático en la provincia de Alto Amazonas, Perú
Authors: Arévalo-Hernández César Oswaldo , Arévalo-Gardini Enrique , Arévalo-López Luis Alberto , Tuesta-Hidalgo Oscar , Romero-Vela Dayani Shirley , Ruiz-Camus Claudia Elizabeth
Published: December 2024

El objetivo del trabajo fue predecir la fertilidad del suelo en la provincia de Alto Amazonas con el uso de imágenes satelitales y técnicas de aprendizaje automático. El estudio se ubicó en la provincia de Alto Amazonas en Perú. Se realizaron muestreos de suelos en toda la provincia, totalizando 100 muestras. Posteriormente se realizaron análisis físicos (textura) y químicos del suelo. Las imágenes satelitales se obtuvieron del USGS y los índices de vegetación se calcularon con base en estas imágenes. Finalmente, se utilizó análisis descriptivo y modelado de aprendizaje automático utilizando 06 algoritmos (GLM, CUBIST, KKNN, SVM, Random Forest y NN) que se seleccionaron en función de su R2 y RMSE.  En este trabajo observamos que la mayoría de los suelos de la provincia tienen bajos pH, P, Mg, K y alta acidez. También se lograron obtener buenas predicciones para pH, Ca, Mg y CIC y se observó que el algoritmo más exitoso fue Random Forest. Sin embargo, para Al, Cubist tuvo mejores resultados. Este es uno de los primeros trabajos que utiliza aprendizaje automático para predecir la fertilidad del suelo en la Amazonía peruana y se espera que pueda servir como base para futuros proyectos.
Retrospective Analysis of Forensic Cases Admitted to the Emergency Department of a Second Level Hospital
Authors: Baykan Necmi , Cakır Yunus Emre , Ipekten Funda , Yakar Sule , Salt Omer
Published: December 2024

Objective: In this study, we aimed to examine the demographic and epidemiological characteristics of forensic cases admitted to the emergency department and the forensic reports prepared for these cases and compare them with the literature.
Material and Method: This retrospective study was conducted in the emergency department of a secondary care hospital for a period of one month. Patients were grouped according to their application time; they were compared in terms of demographic characteristics, forensic report information, and clinical characteristics.
Results: 848 patients were included in the study. The average age of the patients was 30.9±12.5 and most were male (79.5%). While the highest rate of patients was diagnosed with assault algebra (80.2%), the rate of issuing a final report was found to be higher (87.6%). It was determined that the fewest applications were made between 00:00-07:59. No statistically significant difference was found in the comparison of forensic case or forensic report characteristics according to application time (p=0.218).
Conclusion: The number of applications as forensic cases is higher at certain times of the day. Since emergency departments provide uninterrupted service 24/7; emergency department physicians should continue the management of forensic cases regardless of the time of admission and show due care in preparing forensic reports.
Live Streaming Sales, Trust, Content Marketing Tiktok Application and Consumer Buying Interest
Authors: Suryowati Budi , Nur Mila Chofifah
Published: December 2024

The number of TikTok users in Indonesia reached 157.6 million users as of July 2024. Important factors in the social media platform include live streaming sales, trust, and content marketing. This study aims to examine how live streaming sales, trust, and content marketing on TikTok affect consumer buying interest. The population in this study is TikTok application users in DKI Jakarta with a sample size of 100 people obtained using the Slovin formula. Sampling was done using purposive sampling techniques. Data analysis using the Partial Least Square - Structural Equation Modeling (PLS-SEM) method with SmartPLS software version 4. The results of the study show that live streaming of sales on the Tik Tok application has an effect on buying interest. Trust has no effect on buying interest on the Tik Tok Application. Marketing Content Affects Buying Interest on the Tik Tok Application
he effectiveness of virtual reality (VR) therapy on balance and mobility in elderly patients: a randomized controlled trial
Authors: Sekar Madhanraj , Suganthirababu Prathap , Subramanian Shenbaga Sundaram , Vishnuram Surya , Ramalingam Vinodhkumar , Arul Anitha , Anbarason Andrew
Published: December 2024

Introduction. Balance impairments and mobility limitations are prevalent challenges among elderly individuals, often contributing to an increased risk of falls and a diminished quality of life. Traditional physiotherapy interventions have effectively addressed these issues, but novel approaches, such as virtual reality (VR) therapy, have emerged as potential enhancements to rehabilitation protocols. Through its immersive environments, VR therapy may engage and challenge patients, potentially leading to improved outcomes. Objective. To investigate whether VR therapy enhances balance and mobility outcomes in elderly patients compared with a traditional physiotherapy protocol. Methods. Sixty elderly individuals, aged 65 and above, referred for outpatient physiotherapy due to balance and mobility issues, were recruited for this randomized controlled trial (RCT) with two parallel arms. They were randomly allocated to the intervention group, treated with VR therapy sessions, while the control group received traditional physiotherapy sessions focused on balance exercises and mobility. The treatment duration was twice a week for over 8 weeks. Baseline assessments were conducted before the intervention, and follow-up assessments were performed immediately after the 8-week intervention period. Outcome Measures. Primary Outcome: Balance was assessed using the Berg Balance Scale (BBS) as the primary outcome, while mobility was assessed using the Timed Up and Go (TUG) test, and quality of life was evaluated using the EQ-5D Questionnaire as the secondary outcome. Results. The VR therapy group demonstrated a more significant improvement in balance (BBS score increase of 12.4 points) than the control group (BBS score increase of 7.6 points). Regarding mobility, the VR group reduced TUG time by 3.8 seconds, compared to 2.8 seconds in the control group, indicating faster completion times and improved functional mobility. The VR group reported a more significant increase in quality of life (0.17 EQ-5D improvement) compared to the control group (0.12 improvement), suggesting that immersive therapy positively impacted overall well-being. Conclusion. It was anticipated that the VR therapy group would demonstrate more significant improvements in balance, mobility, and quality of life than those in the traditional physiotherapy group.