bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Harga, Promosi, Orang dan Proses Terhadap Loyalitas Pelanggan (Studi Kausal Pt Kintetsu World Express Indonesia - Jakarta)
Authors: Siska Lina
Published: February 2025

Penelitian ini bertujuan untuk  mempelajari pengaruh Harga, Promosi, Orang dan Proses terhadap Loyalias Pelanggan, baik itu secara parsial maupun secara simultan. Penelitian ini merupakan penelitian kuantitatif. Metode yang dilakukan yaitu dengan kuisioner. Data yang digunakan dalam penelitian ini yaitu data primer dan sekunder, pengumpulan data menggunakan kuisioner online (google forms). Sample dalam penelitian ini yaitu seluruh pelanggan yang masih aktif menggunakan jasa PT Kintetsu World Express Indonesia pada tahun 2024 dengan perwakilan populasi yang dijadikan sample yaitu berjumlah 82 sample dengan menggunakan metode probability sampling dengan pendekatan simple random sampling. Teknik analisis data yang digunakan dalam penelitian ini yaitu regresi linier berganda dengan alat analisis SPSS versi 30. Berdasarkan uji t dalam penelitian ini dapat ditemukan bahwa : (1). Terdapat pengaruh positif dan signifikan antara Harga terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia, (2). Tidak ada pengaruh positif (searah) signifikan antara variabel Promosi terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia, (3). Terdapat pengaruh positif dan signifikan antara Orang terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia, (4). Terdapat pengaruh positif dan signifikan antara Proses terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia . Dan berdasarkan uji F dapat disimpulkan bahwa hipotesis (5). Terdapat pengaruh antara Harga, Promosi, Orang dan Proses terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia. Berdasarkan hasil penelitian temuan tersebut, disimpulkan bahwa Loyalitas Pelanggan PT Kintetsu World Express Indonesia akan meningkat apabila PT Kintetsu World Express Indonesia mencapai sasaran dengan meningkatkan mutu harga dan pelayanan yang dibutuhkan oleh pelanggan, sehingga pelanggan dapat melakukan pembelian ulang secara berkala (terus-menerus).
Utility of T3 Therapy in Clinical Practice: A Narrative Review
Authors: D Sanyal
Published: February 2025

Challenges in hypothyroidism management due to persistent symptoms in 5-10% of Levothyroxine (L-T4) monotherapy-treated patients with normal serum Thyrotrophin (TSH) may be addressed by the combination of LT4 and Triiodothyronine (LT3). Though many patients prefer LT4/LT3 combination therapy, there is inadequate robust evidence from Randomized Controlled Trials (RCTs) and long-term studies demonstrating superiority to LT4 alone.

Judicious patient selection to derive maximum clinical benefit and cautious dosing of LT3 without compromising long-term safety is required. Careful consideration is necessary for adding T3 therapy to existing T4 treatment in elective surgeries and Thyroid Hormone Withdrawal (THW) before Radioiodine (RAI) treatment in patients with thyroid cancer. This therapy was observed in patients pre-treated with rhTSH (A/III).

Close monitoring of LT3 therapy is necessary. LT3 therapy is contraindicated in pregnancy, lactation, patients with cardiac arrhythmias and those who are allergic to or intolerant.

Challenges in hypothyroidism management due to persistent symptoms in 5-10% of Levothyroxine (L-T4) monotherapy-treated patients with normal serum Thyrotrophin (TSH) may be addressed by the combination of LT4 and Triiodothyronine (LT3). Though many patients prefer LT4/LT3 combination therapy, there is inadequate robust evidence from Randomized Controlled Trials (RCTs) and long-term studies demonstrating superiority to LT4 alone.

Judicious patient selection to derive maximum clinical benefit and cautious dosing of LT3 without compromising long-term safety is required. Careful consideration is necessary for adding T3 therapy to existing T4 treatment in elective surgeries and Thyroid Hormone Withdrawal (THW) before Radioiodine (RAI) treatment in patients with thyroid cancer. This therapy was observed in patients pre-treated with rhTSH (A/III).

Close monitoring of LT3 therapy is necessary. LT3 therapy is contraindicated in pregnancy, lactation, patients with cardiac arrhythmias and those who are allergic to or intolerant.
A Single Center Prospective Observational Cohort Study on the Association of Asia Pacific Classification of Body Mass Index, Waist Circumference, Waist Hip Ratio with COVID-19 Outcomes and Severity in a Philippine Tertiary Hospital
Authors: Patricia S Quiwa Khia Anne
Published: February 2025

Objective: This study aimed to determine the association between Asia-Pacific classification of body mass index, waist circumference and waist hip ratio and clinical outcomes of COVID-19 moderate & severe patients at the height of the COVID-19 pandemic.

Methods: This study involved adult patients diagnosed with COVID-19. 182 patients were analyzed and divided into 167 moderate and 15 severe COVID-19 patients. Primary outcomes (respiratory decompensation, septic shock and mortality) of patients were compared among Asia Pacific BMI groups.

Results: Among patients with moderate and severe COVID-19, 7 out of 10 patients were obese. Respiratory decompensation and sepsis were more frequently seen in obese patients. Obesity and waist circumference were significantly associated with the odds of respiratory decompensation (95% CI p=0.010 and p=0.002), however this association was not sustained upon adjustment for confounders. On univariate analysis, waist and hip circumferences were significantly associated with the odds of ICU admission (95% CI, p=.013 and p=.034), however after controlling for confounders, only hip ratio retained significant association. Among patients with severe COVID-19, there was insufficient evidence to support significant variations in distributions of outcomes of interest across Asia-Pacific Body Mass Index (BMI) groups.

Conclusion: Our study emphasized that although respiratory decompensation and sepsis were more frequently seen in obese patients. Progression of respiratory decompensation and mortality is not significantly associated with obesity as defined by the Asia Pacific BMI classification, warranting the need for larger prospective studies.
Efektifitas Bauran Promosi Dalam Upaya Meningkatkan Jumlah Nasabah Bank Mandiri Di Kota Padang
Authors: Dianti Muthia
Published: February 2025

Penelitian ini bertujuan untuk menganalisis efektivitas bauran promosi dalam upaya meningkatkan jumlah nasabah Bank Mandiri di Kota Padang. Bauran promosi yang dianalisis meliputi periklanan, promosi penjualan, penjualan pribadi, hubungan masyarakat, pemasaran langsung dan digital. Data didalam penelitian ini dikumpulkan dari 100 orang responden dengan metode survei kuantitatif dengan kuesioner yang disebarkan kepada calon nasabah Bank Mandiri. Data yang dikumpulkan dianalisis menggunakan teknik statistik deskriptif dan regresi untuk mengidentifikasi hubungan antara elemen bauran promosi dan jumlah nasabah. Hasil penelitian menunjukkan bahwa elemen bauran promosi memiliki pengaruh yang signifikan terhadap peningkatan minat menabung, dengan periklanan menjadi elemen yang paling dominan. Iklan yang interaktif dan edukatif serta dengan penawaran menarik terbukti efektif dalam menarik perhatian calon nasabah. 
Tren terkini dalam periklanan adalah personalisasi dan segmentasi, di mana perusahaan menggunakan data dan analitik nasabah untuk memahami preferensi dan kebutuhan individu. Dengan pendekatan ini, perusahaan dapat mengirimkan pesan dan promosi yang relevan secara personal, yang membantu meningkatkan tingkat respons nasabah dan konversi. Selain itu, periklanan memiliki kemampuan untuk mempengaruhi keputusan nasabah. Iklan yang persuasif dan informatif dapat menyampaikan informasi mengenai keunggulan produk, fitur unik, dan manfaat yang ditawarkan, sehingga menarik nasabah untuk memilih produk yang memiliki pesan kuat dan sesuai dengan kebutuhan mereka.
Strategi Promosi Produk dan Meningkatkan Penjualan melalui E- commerce pada Vapemu Store
Authors: Dharmawan Nickra Varel , Fauzan Ahmad , Putra Ramdani Bayu
Published: February 2025

This report presents the findings from the fieldwork conducted at Vapemu Store, focusing on promotional strategies and sales enhancement through e-commerce. The practical work experience provided valuable insights into the significance of innovation in product development and marketing strategies. The team emphasized the importance of introducing new product variants and actively listening to customer feedback, which has proven essential for expanding productivity and market share The project involved effective external communication, serving as a bridge between the fieldwork team, partners, supervising lecturers, and the university institution. A detailed budget was prepared for promotional materials, including banners and souvenirs, to support the marketing efforts The team aimed to motivate Vapemu Store to continue its growth trajectory, improve sales outcomes, and attract a larger consumer base in the future. Recommendations for ongoing development were also provided, highlighting the need for continuous innovation and adaptation to market demands The procedural framework for the project included regular coordination meetings among the fieldwork team, ensuring that activities were well-organized and timely. The report concludes with reflections on the practical experience gained, emphasizing the importance of bridging academic knowledge with real-world business applications Overall, this fieldwork experience not only contributed to the operational success of Vapemu Store but also enriched the students' understanding of practical business dynamics, thereby fulfilling the educational objectives of the internship program.
Pengaruh Disiplin Kerja, Pelatihan Kerja dan Efikasi Diri Terhadap Kinerja Karyawan Pada Dapartemen Engineering Hotel Hanging Gardens Of Bali
Authors: Utami Ni Made Satya , Andika Ary Wira , Darmayanti Ni Kadek Ira
Published: February 2025

Employee performance is one of the keys to a company's success in achieving success. Employee performance is influenced by many things such as work discipline, job training and self-efficacy. This research aims to determine the influence of work discipline, work training and self-efficacy on employee performance in the engineering department of the Hanging Gardens Of Bali Hotel. The population in this study was all 36 employees of the Hanging Gardens Of Bali Hotel engineering department. The type of data used in this research is quantitative. Determining the number of samples using a saturated sampling technique with a sample size of 36 employees. The data analysis technique used is multiple linear regression analysis, F test, t test assisted by the SPSS version 25 program. From the research results, it was found that work discipline had a positive and significant effect on employee performance, work training had a positive and significant effect on employee performance, and self-efficacy. has a positive and significant effect on employee performance.
Analisis Beban Penyusutan Aktiva Tetap Dan Pengaruhnya Terhadap Pajak Penghasilan Badan Pada PT Eka Plafindo Jaya Medan
Authors: Afriani Diana , Salim Denny , Stefvy Stefvy
Published: February 2025

The purpose of this research is to know the impact of implementation of fixed asset depreciation according to income tax provision to entity income tax in PT Eka Plafindo Jaya Medan.       Types of this research is in form of descriptive research with case study in PT Eka Plafindo Jaya Medan. Data which is collected is secondary data include the the depreciation calculation, entity income tax calculation, presentation of financial statement in year 2023 and other information which is related with this research. The research result shows that fixed asset depreciaton method according to income tax provision has impact in increasing of entity’s income tax at PT Eka Plafindo Jaya Medan in year 2023. There is difference between commercial depreciation expense and fiscal depreciation expense because there is difference in using of depreciation method. The company implements straight line method in calculating depreciation expense. The group of fixed asset is not determined properly by the company. The company does not conduct fiscal correction on difference between commercial depreciation expense and fiscal depreciation expense. The company does not calculates the depreciation expense of building, vehicle and furniture properly according to income tax provision. There is improper depreciation rate of fixed asset on building, vehicle and furniture. The depreciation expense in the company is Rp 823,500,000.00. The depreciation expense based on income tax provision is Rp 572,375,000.00. The company should conduct fiscal correction in amount of Rp 251,125,000.00. The fiscal correction will increase the taxable income in amount of Rp 251,125,000.00. The entity income tax in company is Rp 698,748,750.00. After implementation of  depreciation of fixed asset based on income tax provision, the entity income tax expense is Rp 761,530,000.00.
Pengaruh Return On Assets (ROA) dan Return On Equity (ROE) terhadap Harga Saham PT Unilever Indonesia Tbk Periode 2018–2022
Authors: Sitompul Pretty Naomi , Wijaya Selvia Fransiska
Published: February 2025

This study aims to examine the impact of Return On Assets (ROA) and Return On Equity (ROE) on the stock price of PT Unilever Indonesia Tbk over the 2018–2022 period. The research utilizes secondary data derived from the company’s published financial statements. The methodology involves multiple linear regression analysis to evaluate the influence of these two independent variables on stock price as the dependent variable. The results indicate that ROA and ROE collectively have a significant effect on stock price. However, when analyzed individually, ROA exhibits a stronger influence compared to ROE. This research is intended to provide valuable insights for investors in understanding the factors that influence stock prices.
Pengaruh Program Tutor Sebaya Pada Peningkatan Kognitif Belajar Siswa di Sekolah Menengah Atas Negeri 11 Kota Bekasi
Authors: Haiqal Muhammad , Rahmatulloh Muhammad Jizdan , Fadillah Muhammad Raja Zahran , Ranakabbani Rahil , Azzahra Rahmah Afra , Setiawan Budi
Published: February 2025

Arus Globalisasi yang kini telah membawa pada zaman penggunaan serba teknologi, salah diantaranya ialah pendidikan. Kerapkali Siswa dapat lebih mudah memahami Pembelajaran Materi melalui penjelasan yang diajarkan oleh Teman sebayanya, Hal ini dapat dipengaruhi oleh beberapa bagian aspek salah satunya penggunaan metode pembelajaran yang disampaikan oleh Teman sebaya yang memiliki banyak kesamaan gaya belajar pada anak seusia mereka. Adanya Peningkatan Pengetahuan/Kognitif para siswa dalam belajar tentu dapat dipengaruhi dari implementasi Metode Pembelajaran, Media Pembelajaran, Konten Pembelajaran serta Evaluasi Pembelajaran. Tujuan dari Penelitian ini agar dapat menilai keefektifan implementasi Program Tutor Sebaya yang ada Pada SMAN 11 Kota Bekasi pada peningkatan pengetahuan Siswa tersebut, Penelitian ini menggunakan Metode Quasi Eksperimen Kuantitatif, sehingga Hasil Penelitian dapat menampilkan perbedaan Antara Sebelum Menerapkan Program Tutor sebaya dan Setelah Menerapkan pada kegiatan Pembelajaran.
ESG Marketing: Trends and Current Practices
Authors:   Research Scholar, India, Sharma Aanchal , S Wazal Makarand ,   Research Guide & Principal, Sinhgad College of Commerce, Kondhwa Pune, India
Published: February 2025

This paper explores the evolving landscape of Environmental, Social, and Governance (ESG) marketing, a key driver of sustainable and responsible business
strategies. It highlights prominent trends such as regulatory shifts, consumer demand for sustainability, technological advancements, social justice initiatives,
and the rising concerns about greenwashing. A detailed analysis of current practices, including sustainability reporting, stakeholder engagement, and impact
measurement, is presented alongside case studies of leading companies such as Unilever, Microsoft, and Tesla. The paper concludes with future directions
for ESG marketing, emphasizing transparency, innovation, and collaboration.
A epidemiologia do câncer de pulmão no Brasil e sua relação com estratégias em saúde
Authors: Barroso C. R. D. , Barroso M. C. R. D. , Moura I. B. N. , Vieitas G. L. , Geha J. C. N. , Santos S. E. H. , Sardinha N. P. , Arantes J. R. B.
Published: February 2025

O câncer de pulmão é um dos mais prevalentes no mundo, somando cerca de 1,2 milhão de casos novos anualmente, com sobrevida média acumulada total em cinco anos variando entre 7 e 10%. Sua incidência e a mortalidade refletem, em parte, os fatores de risco aos quais uma população foi previamente exposta. O tabagismo, a exposição passiva à fumaça do cigarro, a poluição atmosférica, a dieta e a exposição ocupacional são fatores importantes na carcinogênese pulmonar. Acredita-se que, no ano de 2030, o fumo deverá ser a maior causa isolada de mortalidade, podendo ser responsável por 10 milhões de mortes por ano. Assim, sendo o risco atribuível ao tabagismo como agente etiológico do câncer pulmonar superior a 90%, medidas preventivas de saúde pública tornam-se imprescindíveis no seu combate. O objetivo do trabalho é realizar análise epidemiológica da morbidade e mortalidade do câncer de pulmão. Para isso, foram levantados dados epidemiológicos sobre morbidade e mortalidade da neoplasia maligna de traquéia, brônquios e pulmões, do ano de 2005 a 2014, segundo a plataforma do TABNET no DATASUS e do INCA. Sendo assim, no período entre 2005 e 2014, foram registrados no Brasil 165.134 internações por neoplasia maligna de traquéia, brônquios e pulmões, sendo 15.123 no estado do Rio de Janeiro. Em 2005, foram 14.133 internações no Brasil e 1.574 no Rio de Janeiro, contra 21.219 e 1.760 no ano de 2014, revelando um aumento de mais de 50% em escala nacional e de quase 12% em escala estadual. Em relação ao sexo, embora as internações sejam maiores entre os homens, essa superioridade caiu de 42% para 23% em relação às mulheres. No que diz respeito aos valores totais dos serviços hospitalares, foram quase 200 milhões de reais em despesas médicas durante o período avaliado. Quanto à mortalidade, foram registrados no Brasil 216.051 óbitos, sendo 134.950 em homens e 81.085 em mulheres. A razão de óbitos entre os sexos já foi de 1 óbito entre as mulheres para cada 3,3 óbitos entre os homens, no entanto, segundo os dados apresentados, essa razão já é menor que 1:1,7. Além disso, segundo a distribuição proporcional do total de mortes, no período de 2005-2009, a porcentagem entre os homens era de 14,83%, passando para 14,27% no período de 2010-2014. Já na população feminina, os resultados foram diferentes, visto que os números passaram de 9,56% para 10,54% nos períodos mencionados. Os resultados desta análise evidenciam que o câncer de pulmão no Brasil tem padrão de distribuição com redução da mortalidade para o sexo masculino e aumento da mortalidade para o sexo feminino. Portanto, esses dados podem ser usados no planejamento de políticas públicas visando a prevenção e controle do tabagismo no Brasil, em vista da necessidade de desenvolvimento de novas estratégias e medidas, especialmente entre as mulheres.
Avaliação da Mortalidade de Pacientes com Câncer de Cólon em Estadio III por uso de Quimioterapia Adjuvante
Authors: Cardoso P. , Resende H. M. , Marassi P. H. A. , De Jesus E. C.
Published: February 2025

O câncer colorretal (CCR) é o terceiro tumor maligno mais frequente no mundo. A quimioterapia adjuvante – realizada após a cirurgia – tem como objetivo primordial o controle da doença metastática, e deve ser realizada nos pacientes em Estadio III da doença, quando há comprometimento dos linfonodos. O acréscimo da Oxaliplatina aos esquemas de quimioterapia adjuvante, baseada em 5-fluorouracil (5-FU), trouxe ganhos de Sobrevida Livre da Doença (SLD) – comprovados em estudos. A implantação do protocolo denominado FOLFOX, no qual a infusão do 5-FU se faz de forma contínua, foi avaliada e difundida internacionalmente. Em seguida, o Protocolo FLOX, no qual o 5-FU se faz em bolus (rápido sistema de infusão), foi incorporado pelos principais grupos de CCR no mundo, o que trouxe como vantagem o fato de não necessitar de bomba de infusão contínua e internação do paciente. No entanto, acarreta perfil de toxidade diferente, com uma incidência mais elevada de efeitos colaterais e com decréscimo na toxidade hematológica. O objetivo desse projeto é analisar a toxidade e a taxa de mortalidade de pacientes portadores de câncer de cólon em Estadio III, em uso de quimioterapia adjuvante, através de um estudo longitudinal prospectivo que avaliará pacientes adultos com câncer colorretal tratados por ressecção cirúrgica seguida de quimioterapia adjuvante pelo Protocolo FLOX na Clínica Oncovida – Serviços de Oncologia e Hematologia de Barra Mansa Ltda., localizada na cidade de Barra Mansa, Rio de Janeiro, Brasil. Serão incluídos todos os pacientes com adenocarcinoma colorretal, Estadio III, operados com intenção curativa e tratados entre julho de 2017 a julho de 2020. Serão excluídos pacientes com diagnóstico conhecido de doença inflamatória intestinal e com outras neoplasias malignas, excetuando-se aqueles cânceres de pele não melanoma. Os dados coletados incluirão o Estadiamento clínico e Patológico, CEA (Antígeno Carcinoembrionário) ao diagnóstico, tratamento neoadjuvante, tipo de operação, regime de quimioterapia adjuvante, toxidade ao tratamento e os resultados oncológicos.
 (Agências Financiadoras FOA e CNPq).
Caracterização da prática da automedicação entre graduandos de diferentes áreas do Ensino Superior
Authors: Guidoreni C. G. , Silva N. G. , Reis J. V. C. , Baliza M. S. C.
Published: February 2025

A automedicação pode ser entendida como selecionar e fazer uso de medicamentos a fim de tratar doenças autodiagnosticadas ou sintomas e está associada aos elementos do autocuidado. No Brasil, relaciona-se ao uso inadequado e abusivo de medicamentos, gerando um problema de saúde pública. Com este artigo objetiva-se avaliar e caracterizar a prática de automedicação entre graduandos de diferentes áreas do ensino superior visando comprovar que a automedicação é uma prática muito comum entre os estudantes universitários e com maior incidência nas áreas da saúde, devido a ampliação do conhecimento sobre fármacos. Realizamos um estudo descritivo com aplicação de questionários a alunos da UniFOA que cursavam o 1º, 5º, 6º, 10º e 11º períodos dos cursos de Medicina, Direito e Engenharia Elétrica, abrangendo 143 alunos. 114 realizaram automedicação no último ano, 79% alegaram como motivo o alívio rápido dos sintomas e 93,33% dos alunos do curso de medicina disseram conhecer suas patologias e os efeitos farmacológicos dos remédios utilizados. Nossos resultados mostram que a prática da automedicação é comum entre os universitários, independentemente da área de formação. Evidenciamos, também, que a dor se mostra como principal causa da busca de medicações para o alívio. Ainda que o alívio rápido dos sintomas apareça como um motivo para a não procura dos serviços de saúde antes de iniciar um tratamento medicamentoso, o suposto conhecimento da patologia e/ou dos efeitos do fármaco pesam bastante na decisão dos alunos ao se automedicarem, mesmo que a maioria destes mesmos alunos afirmem saber que esta prática pode mascarar a real patologia.
Medcine – Transplante e tráfico de órgãos
Authors: Barros A. C. W. , Chan Y. C. S. , Coqueiro M. M. , Miranda B. A. , Moraes F. G. V. , Naliati B. C. , Souza G. C. , Zeferino C. S.
Published: February 2025

O transplante é um procedimento cirúrgico que consiste na reposição de um órgão ou tecido de uma pessoa doente (receptor), por outro órgão ou tecido normal de um doador vivo ou morto. O desequilíbrio entre doadores e receptores gera uma estrutura de comercialização, contrabando, tráfico ou comércio clandestino em função dessa dificuldade. O objetivo do presente trabalho é discutir questões envolvidas na compreensão do polêmico cenário do tráfico de órgãos, questões essas que permeiam a ilegalidade criando um paradoxo complexo entre a promoção da saúde em detrimento da saúde de outrem. Com esse intuito, foi criado um vídeo demonstrativo. Para o clipe foram realizados recortes dos filmes: Awake – “A Vida Por Um Fio” e “Coisas Belas e Sujas”, com o programa Windows Movie Maker. Para a parte escrita foi feita revisão de literatura. O clipe foi apresentado em auditório do Curso de Medicina, para alunos do módulo VI e docente do Eixo em Medicina e Humanidades do curso de Medicina do UniFOA. O processo de elaboração do produto nos proporcionou maior conhecimento sobre o tema e sobre as questões legais e médicas que o permeiam e ainda, às referentes aos direitos humanos relacionados ao transplante e ao tráfico de órgãos. Esperamos que após a apresentação do clipe comentado e reflexivo, tal conhecimento possa ser internalizado, expandido, partilhado e multiplicado. A adoção de obras cinematográficas no ensino das humanidades em conjunto com as Tecnologias da Informação e da Comunicação (TICs) são de extrema importância para a expansão do conhecimento e para o enriquecimento da formação médica.
Leucemia mielóide aguda
Authors: Rocha G. H. S. , Cardoso I. F. R. , Glória I. R. , Marquioti F. M. C. , Pereira J. A. C. , Pimentel G. G. , Souza G. H. N. , Cunha C. S.
Published: February 2025

As Leucemias Agudas são neoplasias do sistema hematopoiético caracterizadas pela rápida expansão de um clone celular anormal na medula óssea. Isso leva a um acúmulo de blastos e perda da capacidade de diferenciação em células maduras, sendo a da linhagem mielóide mais comum em idosos acima de 60 anos. A tríade mais comum de sintomas é febre, astenia e hemorragia. E, caso não seja tratada, é fatal, sendo considerada a que tem a menor taxa de sobrevivência entre todas as leucemias. Grande parte dos casos são esporádicos, porém a exposição a agentes ambientais, como quimioterápicos e radiação ionizante, podem contribuir para o surgimento da patologia. M.C.S., 62 anos, feminino, caucasiana, casada, natural de Ervália-MG, residente de Volta Redonda-RJ há 36 anos e diarista há 20 anos, procurou atendimento ambulatorial há 5 meses com quadro febril e fadiga aos pequenos esforços (escovar dentes/tomar banho) e prurido pelo corpo todo, principalmente, na região lombar. No momento da admissão hospitalar, a paciente se encontrava lúcida e orientada no tempo-espaço, REG, eupneica, anictérica, acianótica, hipocorada (+++/4+), hidratada, febril, com petéquias disseminadas e algumas pequenas equimoses de ocorrência espontânea. Com a progressão do caso e a avaliação dos exames solicitados (hemograma e imunofenotipagem), foi diagnosticada com Leucemia Mielóide aguda (LMA), uma vez que constatados marcadores específicos da LMA. Até o diagnóstico final, outras patologias foram apontadas como possíveis causadores da clínica da paciente, como arboviroses, aplasia de medula, síndromes anêmicas carenciais, linfoma e Leucemia Linfoblástica Aguda, sendo esses diagnósticos diferenciais descartados a partir da correta avaliação clínica e de resultados de exames laboratoriais. Portanto, a Leucemia Mielóide Aguda é uma doença prevalente e requer análise criteriosa e direcionamento adequado dos procedimentos, bem como exames complementares específicos para fechar o diagnóstico correto, uma vez que a LMA possui variedade de diagnósticos diferenciais.
A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage
Authors: Afnan Rizwan  , Farooq Muhammad Hassaan , Uzma Nayyer  , Asma Irfan  , Mahwish Farooq  , Maryam Siddique
Published: February 2025

Objectives: To determine the effectiveness of intrauterine misoprostol along with oxytocin versus oxytocin monotherapy for the prevention of primary postpartum haemorrhage.
Method: The quasi-randomised controlled trial took place at the Akbar Niazi Teaching Hospital, Islamabad, Pakistan, from February to August 2021, and comprised women who underwent lower segment caesarean section and at full-term pregnancy who had risk factors for experiencing postpartum haemorrhage. The subjects were randomised into experimental group A and control group B. Group A subjects received both misoprostol and oxytocin, while those in group B received oxytocin only. Data was analysed using SPSS 26.
Results: Of the 120 subjects, 60(50%) were in group A with mean age 28.72±5.82 years and mean gestational age 38.02±1.1 weeks. The remaining 60(50%) subjects were in group B with mean age 29.47±4.72 years and mean gestational age 37.50±1.5 weeks. Group A subjects had fewer changes in haemoglobin levels post-operation than those in group B (p<0.05). The number of operative towels used, contractility time of the uterus, and need for other drugs to control haemorrhage were significantly different in group A compared to group B.
Conclusion: Misoprostol along with oxytocin was found to be more effective in reducing blood loss in patients with postpartum haemorrhage.
Key Words: Postpartum haemorrhage, Misoprostol, Oxytocin, Postoperative blood loss.
A comparative of multiple rib fractures with embracing fixators and rib-locking titanium plates
Authors: Wen Wu , Qiao Yong
Published: February 2025

Objective: To compare the clinical efficacy and safety between embracing fixator and rib-locking titanium plate in the treatment of multiple rib fractures.
Method: The retrospective study was conducted at the Sichuan Province Orthopaedics Hospital, China, and comprised clinical data from January 2020 to December 2022 of patients with multiple rib fractures. The patients were divided into the embracing fixator group A and rib-locking titanium plate group B. Data was analysed using SPSS 22.
Results: Of the 100 patients, 50(50%) were in each of the two groups. There were 35(70%) males and 15(30%) females in group A with mean age 51.38±10.62 years (range: 25-62 years) compared to 33(66%) males and 17(34%) females with mean age 51.48±10.93 years (range: 27-65 years) (p>0.05). Surgical duration and incisional length were shorter, and the blood loss was smaller in group B compared to group A (p<0.05). Three months after treatment, the visual analogue scale VAS) score of group B was lower than group A (p<0.05). All markers of pulmonary function significantly improved both groups (p<0.05) compared to baseline values, but group B patients showed more and better improvement than group A (p<0.05). There was no significant difference in terms of the incidence of complications between the groups (p>0.05).
Conclusion: The rib-locking titanium plate treatment for multiple rib fractures showed the advantages of minimal trauma, simple operation, minimal bleeding, low postoperative pain, significant improvement in lung function, and no increase in postoperative complications.
Key Words: Embracing fixator, Rib-locking titanium plate, Multiple rib fractures, Surgical method, Complications.
Optimizing Kidney Disease Management during Ramadan: Evidence-Based Risk Stratification and Tailored Strategies
Authors: Sourabh Sharma  , Manisha Sahay  , Mastakim Ahmed Mazumder  , Sanjay Kalra
Published: February 2025

Fasting during Ramadan poses distinct challenges forindividuals with kidney disease, requiring a careful balancebetween spiritual commitments and health maintenance.This article combines insights from recent research andguidelines to offer a thorough framework for riskassessment. Patients are classified into low, moderate, andhigh-risk categories based on individual, environmental,and health-related factors. Management approaches areorganized into four main areas: spiritual support, non-druginterventions, medication adjustments, and modificationsto kidney replacement therapy (KRT). Evidence indicatesthat stable chronic kidney disease (CKD) patients, especiallythose in stages 1–3, and kidney transplant recipients withstable graft function can fast safely with carefulsupervision. Conversely, patients with advanced CKD, thoseon dialysis, and individuals with significant additionalhealth issues are advised against fasting due to possiblecomplications. Essential recommendations includeoptimizing hydration, customizing medication plans,conducting regular monitoring, and making dietaryadjustments. By merging medical knowledge with culturalawareness, healthcare providers can facilitate safe fastingand enhance health outcomes during Ramadan.
Keywords: Ramadan, Chronic kidney disease, Religion,Fasting, Dialysis
Intramedullary Spinal Cord Metastasis in Spinal Ependymomas
Authors: Zanib Javed  , Raheema Sadiq  , Hania Fatima  , Muhammad Shahzad Shamim
Published: February 2025

Drop metastasis, or intramedullary spinal cord metastasis(ISCM), is a rare condition accounting 0.9%–5% of CNS orspinal metastases. It arises from tumour cell disseminationthrough cerebrospinal fluid (CSF), often affecting thethoracic and lumbar spine. Clinical features include rapidlyprogressive neurological deficits, limb weakness, sensoryloss, and pain. Diagnosing drop metastasis is challengingand MRI with gadolinium remains the gold standardmodality for investigation. Surgical resection followed byradiotherapy remains the primary treatment option,whereas chemotherapy serves a palliative role in cases ofrecurrence or disseminated metastases.
Keywords: Ependymomas, Drop metastases, Radiotherapy
Factors associated with chilling injury of mango and potential mitigation strategies
Authors: Shrestha S  , Khanal A
Published: February 2025

Mangois a highly valuable fruit crop grown extensively in tropical and subtropical areas, offering considerable nutritional and economic benefits. However, mangoes are susceptible to chilling injury when exposed to temperatures below 13°C during storage, resulting in substantial postharvest losses. This paper explores the factors contributing to chilling injury in mangoes, including pre-harvest genetic variability, climatic conditions, nutritional status, and post-harvest handling and storage practices. The cellular and molecular mechanisms underlying chilling injury, such as membrane integrity, enzymatic activities, ROS accumulation, and hormonal changes, are discussed. Various mitigation strategies are reviewed, including breeding for chilling-resistant varieties, optimal agronomic practices, controlled atmosphere storage, heat treatments, chemical treatments, and emerging technologies like nanotechnology and genetic engineering. The review provided aims to inform better management practices and technological innovations to reduce chilling injury in mangoes, enhancing their shelf life, postharvest qualitiesand marketability.
Floral biology and physico-morphological characteristics of 10 bael (Aegle marmelos) germplasm grown at Chapainawabganj, Bangladesh
Authors: Uddin MS  , Islam MN  , Ferdous Z  , Noman MAA  , Hasan MMM  , Islam MS
Published: February 2025

The experiment was carried out in the research field and laboratory of Regional Horticulture Research Station (RHRS), BARI, Chapainawabganj during 2018 to2019 to know the floral biology and post-harvest physical parameters of ten bael germplasm viz., AM-01, AM-02, AM-03, AM-04, AM-05, AM-06, AM-07, AM-08, AM-09 and AM-10 whichwere grown at Chapainawabganj. The maximum number of pollinations occurred in selected germplasmat 6:00-10:00am when temperature was Cand relative humidity was F. The earliest floweringwas observed at 7 April 2019 in AM-02 germplasm. Theflowering duration was noted in between 51 to 60 days. The maximum anthesis was occurred at 7:00-8:00 am. Estimates for the maximum fruit weight, fruit length, fruit diameter, pulp weight, and skull pulp percentage in the AM-04 were 2900g, 28.90cm, 55.0cm, 2305g, and 79.48%, respectively and lowest fruit weight was recorded 750g in AM-07 compared to the others germplasm. The AM-06 germplasm had the highest recorded number of seeds (170), whereas the AM-02 and AM-08 genotypes had the lowest calculated number of seeds per axil (76). The superior germplasm of Bael is indicated by the lowest seed number.
Integration of Pancasila Student Profile in Islamic Religious Education Textbooks for Senior High School
Authors: Nasrudin Ega , Rahmat Munawar , Anwar Saepul , Kosasih Aceng , Fakhruddin Agus , Firmansyah Mokh. Iman , Rahman Roslan Abdur
Published: February 2025

The realization of students who have the Pancasila Student Profile is the goal of the current government. The rise of the three big sins of education, intolerance, and lack of discipline in the environment of elementary school students is a threat to the disintegration of basic education from within. The government is trying to present Pancasila Student Profile learning through various learning media, one of which is through the open book of PAI and Budi Pekerti. The novelty of this research is that it tries to find the values of the Pancasila student profile in PAI and character education textbooks. The purpose of this study is to examine the content of the Pancasila student profile in PAI textbooks used in high schools. This research method uses a qualitative design of literature study. The data sources of this study are divided into two categories: primary and secondary. Primary data sources come from the triangulation process of high school PAI student books, high school PAI teacher books, and regulatory documents regarding PAI learning in high school. While secondary data sources come from several relevant journals. The collected data were then analyzed in accordance with the stages of content analysis. The findings of this study indicate that Pancasila student profiles in PAI textbooks in high school have the most information, especially the dimensions of faith, devotion to God Almighty, and noble character. The values of each Pancasila student profile are explicitly and implicitly stated in each chapter of the PAI textbook. This study emphasizes that Islamic Religious Education, as one of the subjects mandated by the government, encourages the birth of students who have Pancasila student profiles. The implication of this research suggests that in the future teachers can find out the content of the Pancasila student profile in Islamic Education textbooks so that they can teach the content of the Pancasila student profile optimally
Analysis of the Strategy for Collecting Zakat, Infaq and Sadaqah (ZIS) Funds at the LAZISMU UMY Zakat Institution in Yogyakarta
Authors: Sutrisno Sutrisno
Published: February 2025

This study aims to examine the fundraising strategies for Zakat, Infaq, and Sadaqah (ZIS) at the zakat institution of the oldest private Islamic university in Yogyakarta. The research seeks to identify the effectiveness of fundraising methods employed and analyze the supporting and inhibiting factors in the fund management of the zakat institution, specifically at Lazis LAZISMU UMY. This study adopts a descriptive qualitative approach, utilizing data collection techniques such as interviews, observations, and documentation. The data analysis technique involves data reduction, data presentation, and conclusion drawing. The findings indicate that the institution employs direct fundraising methods, including, face-to-face meetings, salary deductions, donation boxes, digital fundraising, fundraising during events, and door-to-door donation collection. Additionally, indirect fundraising is conducted through; education and awareness programs, strategic partnerships, volunteer activities, sustainable programs, and reward programs. The effectiveness of fundraising through face-to-face interactions and digital platforms is primarily influenced by personal engagement with donors and educational awareness. Supporting factors include the involvement of the academic community, volunteers, and institutional collaborations. In contrast, challenges include competition among zakat institutions, limitations in amil certification and human resources, suboptimal operational management, and insufficient education and facilities. The fundraising strategies play a crucial role in ZIS fund management, contributing positively to fund growth and community benefits. However, the main challenge faced is the inability to fully achieve the targeted fundraising goals.
Stranding of a satellite-tagged southern right whale off southwest Australia
Authors: Harcourt Robert , Sprogis Kate , Gales Nicholas , Andrews-Goff Virginia , Double Mike , Besier Shane , Riekkola Leena , Carroll Emma
Published: February 2025

A southern right whale (Eubalaena australis) was found dead, stranded on a remote rock platform at Torndirrup, Western Australia, on 20 September 2022. Subsequent inspection of the animal showed it had been satellite tagged 11 days prior as part of an investigation into southern right whale movements within inshore breeding grounds and to offshore feeding grounds. This tagged whale was tracked east and then offshore in a southeasterly direction for nine days post tagging, before the track suddenly turned north and ended up at the stranding site. Gross necropsy evaluation was constrained by difficult access, but a rapid inspection of the carcass and collection of tissue samples in situ was conducted on 23 September 2022. The whale had large open wounds on both the back left peduncle region and head region. There was no external or subcutaneous inflammation around the tag site on the front right dorsal side. Findings were inconclusive and mortality could not be attributed to any single event. Possible causes or contributing factors to mortality include an adverse response to the tagging, vessel strike and killer whale predation.
Digital Humanities in Architecture: Towards a Deeper Understanding of Space
Authors: Al-Kadhim Ahmed , Al-Tameemi Osamah , Abdullah Suhail
Published: February 2025

The primary objective of this research is to elucidate how digital humanities can enhance the understanding of architectural space. It is important to underscore the significance of this study, as it applies digital tools and modern technologies to the field of architecture with the aim of interpreting and comprehending spaces for optimal efficiency. The research is carried out adopting a qualitative analytical approach, collecting and analyzing data by the use of 3D models of certain urban spaces and buildings, with a view to offering more detailed insights on the architectural configuration. The literature review section provides insights into the architecture of digital humanities, along with an examination of previous research and relevant theories in this domain. The research methodology outlines the tools utilized, the sample selection, and the data collection processes. Data analysis involves the use of content and contextual analysis tools to draw conclusions. The findings suggest that the application of digital humanities contributes to expanding knowledge, fostering creativity, and offering new perspectives in architectural design thinking, particularly for socially responsible sustainable cities. Finally, the study compares the findings with other research and analyzes them in relation to existing theories, highlighting new contributions to science and potential practical benefits. The study concludes with suggestions and recommendations for future research, emphasizing the continued integration of digital technology in architectural design for spatial analysis and understanding.
Exploring the Role of Resource Based Learning (RBL) and Higher-order Thinking Skills (HOTS) in Enhancing Student Engagement in Primary Science Education: A Case Study from Gombak District
Authors: Norbi Norida , Ruzaina Syed Aris Sharipah , Abdullah Nabilah
Published: February 2025

This qualitative case study explores how six primary science teachers in the Gombak district utilize resource-based learning (RBL) to implement higher-order thinking skills (HOTS) activities and enhance student engagement in primary science education. Teachers with a minimum of five years of teaching experience from the three different types of primary schools were selected as participants. This research investigates how these RBLs are integrated into instructional practices, teaching methods, and assessment strategies to foster HOTS thereby sustaining student engagement in primary science education. The strategies that teachers employ to create resource-rich, inquiry-driven learning environments are examined where students can actively locate, evaluate, and utilize various RBLs. These include textbooks, digital content, multimedia, and other physical materials. Data were collected through classroom observations, semi-structured interviews, and document analysis from six experienced science teachers selected via purposive sampling. All interviews were recorded, translated, and transcribed verbatim. Next, thematic analysis was applied to the transcripts for a comprehensive assessment of the gathered data. Three themes were revealed from the analysis. The findings highlight that the effective integration of RBL significantly enhances student engagement and the development of HOTS. Incorporating these into teaching practices and assessments positively impacts students’ cognitive skills, fostering a more student-centered, interactive, and cognitively enriching learning environment. These findings emphasize the transformative role of RBL in reshaping classroom dynamics and improving HOTS in primary science education.
An Analysis of Syntactical Errors in Essay Writing Among ESL Learners
Authors: Ilahi B. Inafa , Sujani M.J.F. , Nowzath M.B. , Umashankar S.
Published: February 2025

The purpose of the study is to identify the syntactical errors in essay writing of grade 7 students at C.O. Lesthakir International College. The objectives of the study were to investigate the most common syntactical errors made by Grade seven students and to determine the courses of syntactical errors made by the students. The analyze of underlying causes contributing to the synthetic errors in the mixed method is used to explore potential strategies and interventions aimed at mitigating syntactical errors in the essay writing of great seven students. The research was test related to syntactical errors, especially when writing an essay. The proper guidance had been provided to the particular students. Data collection involved interviews, questionnaires, pre-tests, and post-tests with a focus on 35 samples. The findings revealed a significant improvement from 36% in the pre-test to 69% in the post-test. Effective and creative teaching must be done to the students. This teaching should include, proper materials which help the students to improve their understanding in writing an essay without grammatical mistakes. The collected primary data analysis shows the project efforts had established remarkable progress in the selected student’s performance in essay writing. This research is utilitarian for policymakers and government sector professionals.
Development and Evaluation of Mamaxgenius as Teaching and Learning Tool to Understand Maternal Effects
Authors: Faiqah Zamri Nur Ain , Bakar Adibah Abu , Saidin Syazwan
Published: February 2025

Studying maternal effect can be challenging for undergraduate biology students. Game-based learning, such as educational card games, offers a potential solution to enhance understanding of the complex concept. This study aims to develop and evaluate the MamaXGenius card game to aid in teaching maternal effect, a subtopic in genetics. The development phase employed the analyze, design, develop, implement, and evaluate (ADDIE) model and involved 170 biology students from semesters 3 to 7 at Sultan Idris Education University (UPSI). The study utilized a usability questionnaire for the MamaXGenius card game, administered via survey forms. A quantitative approach was used to analyze the data, employing descriptive statistics to calculate mean values, frequency percentages, and standard deviations. Results revealed mean scores of 3.73 (σ=0.480) for content, 3.74 (σ=0.468) for usability and playability, and 3.78 (σ=0.439) for satisfaction, indicating positive perceptions among respondents. The MamaXGenius card game was found to be interesting, usable, and playable, and it received high satisfaction scores from biology students. Thus, novel educational methods for teaching maternal effect should be developed, with educational card games being a viable and cost-effective approach.