bluuebunny/crossref_metadata_2025 huggingface dataset:
EMOLLIENT MILK XEMOSE IN THERAPY OF ATOPIC DERMATITIS IN CHILDREN
Authors: KINDEEVA E T , KOROTKII N G , PAMPURA A N
Published: July 2021

Background. Structural and functional damages of the epidermal barrier in patients with atopic dermatitis promote the entry of allergens and development of Th2-type allergic inflammation. Moisturizers containing lipids increase the physiological antiinflammatory effects of topical corticosteroids (TGKS), improve the epidermal barrier and reduce the duration of TGKS using preventing further infringement barrier. To evaluate the clinical efficacy of emollient milk Xemose in children with atopic dermatitis. Materials and methods. We examined 27 children with atopic dermatitis. Children were divided into 2 groups: patients in group 1 (n=14) used emollient milk Xemose twice a day on the skin lesions and limbs in the complex therapy, patients in the 2nd group (n=13) received combined therapy incorporating traditional dampening agents on the basis of lanolin (Unna cream) 3 times daily. All patients underwent measurement of transepidermal water loss (TEWl) (Tewameter TM 300, Multi Probe Adapter MPA 5/9, Courage + Khazaka) and the pH of the skin (Skin-pH-Meter, Multi Probe Adapter MPA 5/9, Courage + Khazaka) before and after 2 weeks of therapy. Results. Patients in groupthat used Xemose milk and children in group with Unna cream after 2 weeks showed a statistically significant decrease of TEWl (p=0,041 and p=0,04, respectively). TEWl was significantly lower in children treated for 2 weeks with milk Xemose (p=0,027) than in children treated with Unna cream. in both groups pH skin surface have not changed (р=0,22 and р=0,22 respectively). Conclusion. Clinical efficacy of milk Xemose as compound improving skin barrier function in children with atopic dermatitis was shown.
The relationship between sensitization to allergens of cow’s and goat’s milk at children with atopic dermatitis
Authors: Varlamov E E , Okuneva T S , Pampura A N
Published: July 2021

Introduction. The main principle of treatment of cow’s milk allergy (CMA) is the elimination from the diet of cow’s milk. However recently has been discussing the possibility to substitute the cow’s milk with goat’s milk in children with allergy to cow s milk protein. Background. To determine the relationship between sensitization to cow’s milk specific allergens in goat’s milk sensitized children. Methods. The study included 88 children with suspected allergy to CMA. All patients underwent determination of specific IgE to allergen of cow’s and goat’s milk allergen (ImmunoCAP 100 Phadia AB). We identified 35 children with sensitization to cow’s milk and measured specific IgE to α-laktalbumin, β-lactoglobulin and casein. Results. Sensitization to goat’s milk was estimated in 83% of patients with sensitization to cow’s milk. There was a significant positive correlation between the concentration of specific IgE to goat’s milk allergen and specific IgE to the cow’s milk allergen (R=0,91, p=0,0000001), a-laktalbumin (R=0,76, p=0,000007), β-lactoglobulin (R=0,72, p=0,000038) and casein (R=0,91, p=0,0000001). Conclusion. Formulas based on goat milk can not be considered hypoallergenic for children allergic to cow’s milk. Crosssensitization is mediated mainly with sensitization to casein. Introduction of goat milk and its derivatives in the diet of a child with an allergy to cow’s milk can be proven only by the absence of clinically relevant sensitization to goat milk.
Sertaconazole in treatment of atopic dermatitis patients
Authors: Elisyutina O G , Fedenko E S , Shtirbul O V
Published: July 2021

The role of Malassezia and Candida infection in pathogenesis of atopic dermatitis, as well as the results of Sertaconazole cream efficiency in atopic dermatitis are given in the article.
RATIONAL PHARMACOTHERAPY OF CHRONIC URTICARIA
Authors: Nekrasova E E , Ponomareva A V , Fedoskova T G
Published: July 2021

The aim of this study was to reveal most clinically effective and economically expedient anti-H 1-receptor antagonist cetirizine generation (original or generic), to carry out the analysis of pharmaceutical equivalence of cetirizine generation anti-H-receptor antagonists manufactured by different companies. Materials and methods. Study is executed in design of simple open comparative prospective randomized research in parallel groups. The preliminary analysis of volume and structure of H-antihistamine cetirizine generation products retails for the purpose of definition of the most widespread trademarks was carried out 117 patients with chronic idiopathic urticaria (CIU) treated with various trademarks cetirizine 10 mg/day within 4 weeks were included in the study. Clinical efficiency criteria: dynamics of urticaria symptoms, change of index severity, remission period, days free from CIU symptoms. The pharmaceutical analysis included comparative studying of rate of dissolution and quantitative identification of medicinal substance. The pharmacoeconomic analysis was done by an «expense-efficiency» method. Results. All investigated drugs of cetirizine in a dose of 10 mg dayly significantly (p Cetirizine-Hexal > Zodak.
The level of free hemoglobin, eosinophilic cationic protein and eosinophils in nasal secret in patients with allergic and infectious rhinitis
Authors: Mokronosova M A , Kochetova Yu I , Smol'nikova E V , Protasov P G , Mokronosova M A , Kochetova Ju L , Smolnikova E V , Protasov P G
Published: July 2021

Background. Allergic rhinitis manifestates as the local inflammation with minimum pathophysiological disorders. Revealing of local inflammatory markers in nasal secret is actual problem. The aim: to detect the levels of free hemoglobin, eosinophilic cationic protein and eosinophils in nasal secret in patients with allergic rhinitis and infectious rhinitis. Materials and methods. 60 patients with allergic rhinitis and 30 patients with infectious rhinitis were observed. The diagnosis and severity of disease were rated in conformity with international standards. Results. Mean level of free hemoglobin in patients with allergic rhinitis was significantly higher in comparison with the group of infectious rhinitis and had compiled 55,9 mkg/ml and 6,1 mkg/ml. The quantity of eosinophils more than 10% was observed in 43,9% of cases in patients with allergic rhinitis and in 11,1% in patients with infectious rhinitis. Frequency of elevated level of eosinophilic cationic protein in patients with allergic rhinitis has made 87,9%, in comparison with infectious rhinitis where it corresponded to 28%. The highest sensitivity (87,9%) was found in method of definition of eosinophilic cationic protein. Method of free hemoglobin's definition was characterized by high parameter of correct diagnosis's probability - 97,3%. Conclusion. Methods of definition of eosinophilic cationic protein and free hemoglobin in nasal secret had possessed with the highest diagnostic efficiency.
Pharmacogenetics of uncontrolled asthma
Authors: Kulikov E S , Ogorodova L M , Freidin M B , Deev I A , Rudko A A , Selivanova P A
Published: July 2021

This review summarizes the results of pharmacogenetic studies of determination response to drugs used for the treatment of bronchial asthma. Pharmacogenetic information will enable the use of a personalized approach to the asthma management, which will adjust the therapy technology and increase the possibility of achieving disease control.
Poly-functional anti-allergic activities of anti-histamine drug - rupatadine
Authors: Gushchin I S
Published: July 2021

Rupatadine is a new agent for the management of diseases with allergic inflammatory conditions. Rupatadine is a dual inhibitor of H 1- and platelet-activating factor (PAF)-receptors and possesses a broader profile of antiallergic properties inhibiting allergy target cells and secretion of different mediators involved in the early- and late-phase of allergic response. Rupatadine is a real example of poly-functional anti-allergic remedy.
Allergy to latex - current state of problem
Authors: Evdokimova T A , Fedorova O S , Fedotova M M
Published: July 2021

During the last 20 years the incidence of sensitization to latex proteins is growing. Allergy to latex is found predominantly in persons, professionally contacting with latex products: medical workers, workers employed in the manufacture of rubber products and food workers. This review describes the main clinical symptoms of latex allergy, characteristics of structural proteins and their basic biological functions. Modern methods of diagnostics and approaches to the application of specific immunotherapy for allergy to latex are presented.
SIRNA-MEDIATED INHIBITION OF INTERLEUKINE-13 PRODUCTION IN VITRO
Authors: Shilovskiy I P , Mazurov D V , Shershakova N N , Khaitov M R
Published: July 2021

Background. According to current views, one of the major mediators involved in the development of allergic process is IL-13. The goal of this work was to design small interfering RNA molecules to effectively inhibit il-13 gene expression of mice in experiments in vitro. Methods. For the expression of IL-13 in in vitro gene coding sequence il-13 was amplified using cDNA ConA-stimulated spleen cells from BALE / c mice as a template and cloned into the expression vector pUCHR IRES GFP. Using a computer analysis were designed six variants of siRNA, directed against mRNA-il-13. To test the efficiency of siRNA a co-transfection of 1x 105 cells HEK293T mixture (0,5 mg and 1 mg of plasmid siRNA) coupled with Lipofectamine 2000 reagent was carried out. Twenty-four hours later, the gene expression changes in il-13 recorded by flow cytometry on the fluorescence intensity of GFP+-cells. Gene expression of il-13 mRNA was assessed by quantitative PCR, and the level of the protein product by ELISA. results. As a result, siRNA molecules were obtained and three of them were able to effectively inhibit the gene expression of il-13. Conclusion. Thereby variants of siRNA, which can effectively inhibit the production of mice’s IL-13 in vitro; can be used later in experiments in vivo so to understand the role of IL-13 in the pathogenesis of allergic conditions as to develop new therapy approaches.
Sublingual immunotherapy - questions of efficiency and safety
Authors: Manzhos M V , Fedenko E S , Myagkova M A
Published: July 2021

The basic results of clinical researches on efficacy and safety studying sublingual allergenspecific immunotherapy (slASIT) are presented in the review. The results of SUBLINGUAL application of allergens in Russian Federation are presented.
ANTIHISTAMINE THERAPY EFFICACY IN PATIENTS WITH CHRONIC IDIOPATHIC URTICARIA
Authors: Golubchikova R N , Danilycheva I V
Published: July 2021

Background. Estimation of efficacy of antihistamines in patients with various severity levels and various clinical and laboratory variants of chronic idiopathic urticaria (CIU) . Methods. The retrospective study of the anamnestic clinical laboratory findings in 196 patients with CIU was performed. Results. The frequency of patients with full effect of antihistamines was 69%, partial efficacy — 11%, lack of efficacy — 20%. Lack of efficacy was dominated in patients with severe course of the disease and the presence of clinical manifestations of autoimmune disorders, non-specific inflammation and / or signs of cutaneous vasculitis. The full effect of antihistamines was dominated in patients with mild to medium CIU, with a normal clinical blood count and with a negative skin test with autologous serum. Conclusion. Lack of efficacy of of antihistamines in patients with severe course of disease, signs of autoimmune disorders specify on others nonhistamine mediators in CIU pathogenesis and application of the second and third line therapy of CIU.
Atopic dermatitis in children and specific IgE to Stahpylococcus aureus superantigens: a compare with disease severity
Authors: Treneva M S , Pampura A N , Okuneva T S
Published: July 2021

Background. Staphylococus aureus (S. aureus ) function in atopic dermatitis (AD) children skin is double-handed: an infectious trigger and an allergen. The study was aimed to evaluate a frequency of S. aureus enterotoxins IgE work out in children with infected AD skin and to compare IgE levels with infected AD severity. Methods. Specific IgE to S. aureus enterotoxins A and B (ImmunoCap, Phadia AB, Sweden) detected in serum of 90 children with infected AD. IgE levels were compared to severity of infected AD (Mann—Whitney Utest). Results. Specific IgE>0,35 kUA/l to S. aureus enterotoxin A frequency was of 0,29; to enteritoxin B 0,36; to one of them 0,43. IgE to S. aureus enterotoxins were elevated in 16 children with therapy resistant AD in compare to other cases of AD (р=0,00183). Conclusion. In children with infected AD S. aureus enterotoxins A or/and B are revealed in 25—50% of cases. In children with therapy resistant AD specific IgE level to enterotoxins is elevated in comparison to severe or average AD children.
Atopic dermatitis. When and how to use topical corticosteroiods?
Authors: Fedenko E S
Published: July 2021

Atopic dermatitis is a disease characterized with increasing prevalence around the world. It has chronic relapsing course and has a negative impact on the quality of life. Topical steroids (TS) due to their mechanisms of action remain the mainstay of topical treatment for AD patients. At the same time, well known side effects associated with corticosteroid therapy, although seen more frequently with incorrect TS use, and rare with the use of modern TS, in some instances limit their use. That is a reason for proper selection of topical treatment algorythms of AD including emollients and other medications in addition to the TS.
Arterial dysfunction and systemic inflammation in patients with bronchial asthma
Authors: Sobko E A , Kraposhina A Y , Ischenko O P , Demko I V , Salmina A B , Burakov A Y , Prugova V L
Published: July 2021

Background. The objective of this study was to estimate a vascular wall status of large arteries and function of endothelium in patients with different clinical forms of bronchial asthma throughout the disease progression. 220 patients with bronchial asthma have been examined, including 106 persons with moderate asthma ( 1 st group), 61 persons with severe asthma (2 nd group), and 53 persons with steroid-dependent asthma. Control group was formed from 40 healthy donors. Methods. We have assessed parameters of external respiration, arterial rigidity, and the levels of TNFα, IL-6, sCD31 (sPECAM-1), CRP in the peripheral blood at the time of exacerbation and 48 weeks later. Results. We found elevation of IL-6 and TNFα levels in all the tested groups in the period of exacerbation comparing to the control group (p
Modern treatment of allergic conjunctivitis
Authors: Shvets S M
Published: July 2021

The article presents allergic conjunctivitis as an allergic disease affecting the occular surface and it’s modern treatment.
Topical antibacterial and combined therapy of pyoderma and complicated atopic dermatitis with mupirocin
Authors: Elisyutina O G , Fedenko E S , Shtyrbul O V
Published: July 2021

Clinical efficacy of topical mupirocin in pyoderma and atopic dermatitis complicated with bacterial infection was established.
The estimation of efficiency of diet therapy in atopic dermatitis and food allergy in children
Authors: Revyakina V A , Sharapova K G , Berezina E YU , Sentsova T B , Monosova O YU , Zotova A M
Published: July 2021

Background. Clinical and immunological estimation of efficiency of different special formulas in children with atopic dermatitis due to food allergy. Methods. Fifty four children with atopic dermatitis aged 0,5—3 years old were examined. Children were divided into three groups on the base of their diet therapy. The 1 st group included 15 patients on the hypoallergenic milk-free diet, the 2 nd group (18 patients) was fed by goat milk formula, and the 3 rd group (21 children) was fed by special formula with high hydrolyzed protein. The dynamics of serum levels of IgE and IgG antibodies to cow milk protein and its fractions, and dynamics of cytokine levels (IL-4, IL-5, and IL-10) were measured during different types of diet therapy. Results. The positive skin changes during diet therapy included decrease of erythema, exudation and itching, gradual regression of rash. In 3 months of therapy complete clinical remission was achieved in 10 (66,7%) children in the 1 st group, in 14 (77,8%) children in the 2 nd group and in 15 (71,7%) children in the 3 rd group. The significant decrease of levels of IgG antibodies levels to cow milk protein and its fractions in children during different elimination diets was determined. The significant decrease of levels of specific IgE antibodies to cow milk protein (p
Family principles of children rehabilitation with atopic dermatitis
Authors: Kaznacheeva L F , Ishkova NS , Kaznacheev KS , Dubrovina L N , Nechaeva N I , Kaznacheeva L F , Ishkova N S , Kaznacheev K S , Dubrovina L N , Nechaeva N I
Published: July 2021

Background. Аn estimation of a family method efficiency of children rehabilitation with atopic dermatitis. Materials and methods. There were 88 families under medical survey where children with atopic dermatitis lived. These families were divided into two groups: the first group (basic) - 68 children who passed rehabilitation according to a family principle at the consulting center of family rehabilitation; the second group (control group) - 20 children, who improved their health with a traditional method. Catamnesis data was used as the methods of rehabilitation control of efficiency with an estimation of frequency and recurrences severity of the basic disease of SCORAD index change, numbers of references to the doctor in occasion of concomitant diseases were used. Results. The positive effect in dermatitis treatment was achieved at 66 among 68 patients (97,1%). 2-3 fold decrease of frequency of the recurrences was observed at 56 children (82,4%), decrease in the defeated area - at 53 children (77,9%). The positive effect was observed in 6 out of 20 children (30%) (p
OLYMP programme-basic clinical immunology programme as a part of continued medicaleducation for pediatritians. Mechanisms of the allergoprotective action of thebreast milk and its substitutes.
Authors: Yartsev M N , Davydova A N , Abdullaeva G A , Yartsev M N , Davidova A N , Abdullaeva G A
Published: July 2021

In the article possible immunological mechanisms of feeding influence on the health status are discussed. Importance of breast feeding for preventive maintenance of allergic diseases, as well as effectiveness of modern mixes enriched by prebiotics is underlined.
Efficien cy of Aminoacid Formula in dietotherapyof food allergy in children : clinical eviden ces
Authors: Taran N N , Filatova T A , Lavrova T E , Taran N N , Filatova Т А , Lavrova Т Е
Published: July 2021

Cow's milk allergy (CM A) is the most common food allergy in young children. Babies who develop cow's milk
protein (CMP ) allergy may have one or several of the following symptoms: skin rash or gastrointestinal symptoms
(abdominal pain or cramps, vomiting or diarrhea). The symptoms can be controlled through a dairy-free diet. So
the diagnosis and elimination of CMP is an essential element in management of children with CM A. This article
provides a summary of extensive clinical research behind the Nutrilon Aminoacid, demonstrating the clinical
efficacy through 25 years of experience.
Levocetirizine in allergic rhinitis and rhinoconjunctivitis treatment(review)
Authors: Lopatin A S , Latysheva E N , Lopatin A S , Latisheva E N
Published: July 2021

This review is devoted to efficacy and safety of levocetirizine in allergic rhinitis treatment. Levocetirize has been
shown to be able to control all symptoms of allergic rhinitis including nasal obstruction, it has anti-inflammatory
and immunomodulatory activity. Levocetirizine has been proven to be safe even in long-term administration
and has less adverse reactions in comparison with other antihistamine drugs. So, levocetirizine is efficacious
and safe medication for treatment patients with mild-to-moderate seasonal and perennial allergic rhinitis and
rhinoconjunctivitis.
Study of inert cellulose powder effect on the nasal mucosa
Authors: Angotoeva I B , Sukhovetchenko E V , Angotoeva I B , Suhovetchenko E V
Published: July 2021

Background. To investigate the efficiency, safety of inert cellulose powder in allergic rhinitis, and influence
on mucous tunic of nasal cavity.
Materials and methods. Two groups of patients were examined in this research (30 healthy volunteers and
30 patients suffering from allergic rhinitis). The following factors of patients' life and health condition were
evaluated during the investigation: quality of life, the condition of mucous tunic, mucociliary clearance rate,
the ciliabeat frequency of ciliated cylindrical epithelium, the signs of inflammation in the smears of mucous
tunic before and after the treatment with Nazaval and Nazaval Plus.
The results. Nazaval and Nazaval Plus improved the quality of life index and reduced the inflammation signs
of mucous tunic of nasal cavity examined by rhinoscopy and endoscopy. No ciliotoxic effects of preparations
on mucous tunic were established.
Conclusion. The inert cellulose powder is a highly effective and safe product for the treatment of allergic
rhinitis.
Primary immunodeficienciesin adults
Authors: Latysheva T V , Setdikova N Kh , Latysheva E A , Dmitrieva A V , Yurenkova A A , Latysheva T V , Setdikova N Сh , Latysheva Е А , Dmitrieva A V , Urenkova A A
Published: July 2021

This article presents data on the prevalence of primary immunodeficiency diseases (PID ) in R ussia, reflects
the problems of the adult age patients with PID diagnosis. I t substantiates the necessity of inclusion of this
disease into the list of orphan diseases, that entitles the patients to be provided with expensive treatment irrespective
of the age and disability group. T he article shows clinical and laboratory criteria required for the general
practice doctors to diagnose timely the PID .
Tacrolimus in moderate and severeatopic dermatitis treatment. The first clinical experience in Russia
Authors: Elisyutina Ol'ga Gur'evna , Fedenko E S , Shtyrbul O V , Niyazov D D , Elisyutina O G , Fedenko E S , Shtyrbul O V , Niyazov D D
Published: July 2021

Background. The clinical efficiency and safety of tacrolimus ointment 0,1%, accessible in the Russian market since 2011, in moderate and severe atopic dermatitis (AD) were investigated. The assessment was based on the data of tacrolimus using in routine clinical practice under the registered indication.
Methods. There were 19 moderate and 11 severe AD patients under supervision. Treatment with tacrolimus ointment 0,1% was started with twice a day application. Duration of this treatment was from 1 to 4 weeks (18±4,2 days) up to skin clearance. When symptoms were reduced, the frequency of tacrolimus application was reduced as well to once a day daily, and than to twice a week. Generally, improvement was observed within one week of treatment. Clinical efficiency was assessed by SCORAD index and Investigators' Global Assessment (IGA). Results. Positive clinical effect of tacrolimus 0,1% ointment therapy was found in 90% of AD patients resulted in significant reduction of dryness, rushes, skin itch, SCORAD and IGA indexes.
Conclusion. Tacrolimus 0,1% ointment is effective and safe for treatment of severe and moderate AD. It should be applied both as exacerbations treatment and as maintenance therapy in AD patients.
Clinical effectiveness of efferent methods in complex treatment of atopic dermatitis
Authors: Yudina S M , Ivanova I A , Rusanova T S , Yudina S M , Ivanova I A , Rusanova T S
Published: July 2021

Background. Clinical effectiveness estimation of efferent methods in complex treatment of Atopic Dermatitis.
Method. the clinical effectiveness of intravenous laser blood radiation treatment (ivlBR), intravenous ultraviolet
blood radiation treatment (ivUvBR) and extracorporal immunopharmacotherapy (eipt) was estimated in
198 patients with different clinical types of Atopic Dermatitis. Group of control included patients with standard
basic therapy.
Results. in patients with Atopic Dermatitis who had complex treatment ivlBR, ivUvBR, eipt was more rapid
regression of inflammatory skin process and dynamic of index SCORAD were more rapid. this leaded to saving
therapy time and reduction of relapses.
Conclusion. the best effectiveness in treatment of Atopic Dermatitis complicated by secondary infection has
ivUvBR or eipt with diuciphonum; in treatment of non-complicated of Atopic Dermatitis has ivlBR or eipt
with dexametason.
FUNGAL ALLERGY
Authors: Tsarev S V , Tsarev S V
Published: July 2021

Fungal allergy is discussed in this review. Aerobiological, epidemiological data are presented. Immunobiology
of fungal (mould and yeast) allergens and mechanisms of fungusinduced allergic diseases also summarized in the review. Fungi are ubiquitous in environments. Mold spores are found both indoors and outdoors. Most
fungi are not pathogenic to healthy humans while some cause diseases. Molds and other fungi produce allergens, irritants, and toxic substances (mycotoxins)
Dynamics of clinical symptoms and immunity local parametres during allergen - specific immunotherapy in patents with pollinosis and combined forms of sensibilization
Authors: Bezrukova E V , Molotilov B A
Published: July 2021

Background. To evaluate clinical and immunological efficiency of immunotherapy of pollinosis patients with
combined forms of sensitization with «Sevapharma» allergens, Czech Republic.
Materials and methods. 189 patients with pollinosis (age 18-55 years old) were examined during this study. Out
of these 189 patients three groups were chosen to be treated with pollen allergens made in Czech Republic and
domestic allergens from Russia. During the study slgA in saliva was examined and the efficiency of different
AS IT methods with combined forms of sensitization was tested.
Results. Patients with pollinosis had disruption in local immunity. slASIT increases slgA production in saliva.
Treatment with interfacing allergens is most effective in combined forms of sensitization.
Conclusion. The sensibilization to different kinds of pollen allergens was observed in 10- 15% of cases. Combined
forms of sensitization are much more common. Moreover, combined forms of sensitization to pollen and domestic
allergens predominate. Besides that, the study showed pollinosis patients have disruption of local immunity that
appeared in slgA deficit in oral cavity. Sublingual immunotherapy is the most effective method of treatment. In
case of combined forms of sensitization treatment with interfacing allergens is the most efficient.
PELATIHAN KEWIRAUSAHAAN STRATEGI ONLINE MARKETING UNTUK MEMPERLUAS PASAR
Authors: Afif Hakim  , Nana Rahdiana  , Annisa Indah Pratiwi
Published: July 2021

Sebagai seorang entrepreneur harus selalu berupaya mencari ide kreatif agar usaha yang dijalankan dapat terus berjalan. Salah satu improvement yang dapat dilakukan adalah mengubah strategi pemasaran dari konvensional (offline)  menjadi online atau yang sering disebut online/internet marketing terlebih lagi pada saat kondisi pandemic Covid-19 seperti saat ini. Untuk menjalankan online marketing memang tidak mudah dan butuh ketelatenan. Banyak para peserta yang beranggapan bahwa strategi online marketing sulit untuk dilaksanakan pada hal mereka menyadari bahwa strategi online marketing efektif untuk dilaksanakan terutama di saat-saat pandemic covid-19 ini sehingga pelatihan semacam ini penting untuk dilaksanakan untuk menghilangkan gap berupa ketidaktahuan para peserta. Pelatihan berjalan dengan lancar dan para peserta terlihat antusias dalam melaksanakan pelatihan ini terbukti dari banyaknya pertanyaan yang dilontarkan dan hasil survey feedback menyatakan bahwa 100% mereka setuju pelatihan membawa manfaat untuk pengembangan usaha.

 Kata kunci— entrepreneur, Covid-19, online marketing

As the entrepreneur, they must always try to find creative ideas so that his business can continue to run. One of the improvements that can be made is to change the strategy from conventional (offline) marketing to online or what is often called online / internet marketing first during the Covid-19 pandemic conditions like today. To run online marketing is not easy and requires patience. Many participants thought that online marketing strategies were difficult to implement when they realized that an effective online marketing strategy was to be implemented, especially during this time of the Covid-19 pandemic, so this kind of training is important to carry out to eliminate the gap in the form of participants' ignorance. The training went well and the participants seemed enthusiastic in carrying out the training as evidenced by the many questions asked and the survey results which stated that 100% of them agreed that the training was beneficial for business development.

 Keywords—entrepreneur, Covid-19, online marketing
PENDAMPINGAN PADA INDUSTRI MAKANAN
Authors: Syaeful Arief
Published: July 2021

Pengabdian kepada masyarakat merupakan kegiatan yang menjadi salah satu pilar tegaknya Tri Dharma Perguruan Tinggi. Dengan melaksanakan kegiatan ini, institusi pendidikan tinggi secara langsung mendharmakan dirinya memberikan solusi-solusi untuk masyarakat. Pengabdian kepada masyarakat dilaksanakan dengan program Pendampingan dengan kasus yang disesuaikan dengan kondisi lapangan masing-masing IKM. Lokasi pengabdian adalah sekelompok industri makanan yang berada di seputaran Desa Kecamatan Godean Kabupaten Sleman. Atas saran dan arahan kelompok, sebagai sasaran khusus dipilih Kelompok PKK dengan beragam kondisi dan kemampuan produksi dengan harapan Kelompok tersebut dapat menjadi agent of change bagi kelompok yang lain. Hasil dari kegiatan pendampingan masyarakat adalah, Kesadaran yang rendah terhadap pentingnya keselamatan kerja, Belum adanya perencanaan produksi yang tersistematis, Proses produksi yang masih menggunakan alat tradisional, Tempat kerja yang tidak higienis dan tidak ergonomis, Luas lantai produksi yang tidak optimal, Utilisasi peraalatan yang rendah, Produktivitas rendah

Kata kunci: IKM, industri makanan, Produktifitas.

 

 

Community service is an activity that is one of the pillars of upholding the Tri Dharma of Higher Education. By carrying out this activity, the higher education institution directly dedicates itself to providing solutions for the community.

 

Community service is carried out with the Assistance program with cases adapted to the field conditions of each IKM. The service location is a group of food industries located around the village of Godean District, Sleman Regency. Based on the group's suggestions and directions, PKK groups with various conditions and production capabilities were selected as special targets in the hope that these groups could become agents of change for other groups. The results of community assistance activities are, low awareness of the importance of work safety, absence of systematic production planning, production processes that still use traditional tools, unhygienic and un ergonomic workplaces, non-optimal production floor area, low equipment utilization. , Low productivity

Key words: IKM, food industry, productivity.
Pembuatan Buku Profil Taman Kanak-Kanak dan Taman Pendidikan Al-Qur'an Daarussa’adah Depok
Authors: Wijayanto Catur Sunu , Alam Bambang Perkasa , Masri Zainal Arifin
Published: July 2021

Taman Kanak-kanak dan Taman Pendidikan Al-Qur’an Daarusa’adah adalah salah satu tempat pendidikan yang ada di Depok. Strategi promosi dan informasi dengan cara-cara dan proses konvensional yaitu dengan pembagian brosur, spanduk dan penyampaian informasi dari satu orang ke orang yang lain dirasa belum optimal maka dari itu kami membuat buku profil Taman Kanak-kanak dan Taman Pendidikan Al-Qur’an Daarusa’adah Depok yang dapat digunakan sebagai media promosi dan informasi sekolah. Dalam pembuatan buku profil ini kami menggunakan beberapa metode di antaranya: Metode pendataan meliputi kepustakaan, observasi, wawancara dan metode pendekatan masalah yaitu analisis perancangan, pemotretan dan pencetakan buku. Buku profil ini tidak hanya dibuat dan dipromosikan tetapi kami juga menyosialisasi bagi pihak mitra tentang manfaat pembuatan buku profil serta  mengajarkan bagaimana caranya membuat buku profil. Dengan demikian pihak sekolah tidak hanya menggunakan buku profil ini sebagai promosi dan sebagai media informasi yang ditujukan kepada masyarakat luas tetapi juga mengetahui bagaimana cara membuat buku profil.
Pelatihan Pemasaran dan Produksi serta Pendistribusian Makanan di Masa Pandemi Covid-19 pada Usaha Waralaba Makanan di Wilayah Depok Jawa Barat
Authors: Syahrudi Syahrudi , Wahbi Abdul Azim
Published: July 2021

Dalam mencegah dan menangani kondisi dan dampak wabah Covid-19 di Indonesia, maka dipandang perlu menjaga ketersediaan pangan olahan yang berkualitas bagi masyarakat Indonesia. Dalam melaksanakan praktik pemasaran produksi, distribusi dan ritel pangan olahan, kami sebagai dosen memandang perlu melakukan pelatihan dan penyuluhan tentang pemasaran serta pencegahan penyebaran Covid-19 dan memastikan penerapan sesuai dengan panduan selama masa pandemik Covid-19.Diharapkan dengan diadakannya pelatihan ini, pelaku usaha dapat menerapkan dengan baik sehingga dapat mencegah penyebaran Covid-19, dan penjaminan keamanan dan mutu pangan olahan dapat terus ditingkatkan Pengabdian kepada masyarakat yang akan dilaksanakan fokus pada pelaku usaha waralaba Rafiza Fried Chiken yang tersebar di wilayah Depok Jawa Barat sebagai target program dengan tujuan agar pelaku usaha UMKM mendapatkan pemahaman mengenai pelatihan pemasaran, pengolahan dan pendistribusian makanan yang aman dan berkualitas, sehingga pemahaman tersebut dapat diterapkan dalam kegiatan usaha serta dapat memperbaiki kualitas usaha yang sedang dijalankan.
PENGARUH PENDIDIKAN KESEHATAN TENTANG SADARI SEBAGAI DETEKSI DINI KANKER PAYUDARA TERHADAP PENGETAHUAN DAN SIKAP SISWI SMK SWASTA YAPIM BALIGE TAHUN 2020
Authors: Nababan Dosmaida
Published: July 2021

This study aims to determine the effect of health education on BSE as an early detection of breast cancer on the knowledge and attitudes of Yapim Vocational School students, Balige District, Tobasamosir Regency in 2020. This research is a quasi-experimental research type, using the pretest-posttest design method, namely by how to give a pre test (initial observation) before the intervention is carried out, after being given the intervention then a post test (final observation) is carried out. The research was conducted at Yapim Vocational High School, Balige District, Toba Samosir Regency, from January to March 2020. The research subjects were a total of 91 Yapim Balige Vocational School students. The statistical test used is the Wilcoxon test. The results of the pair t-test analysis of pre-test and post-test of knowledge. So, it is concluded that there is an effect of health education on BSE on student knowledge. The result of pair t-test analysis result pre test and post test attitude obtained p value = 0.000, meaning p value> 0.05. So, there is an effect of health education about BSE on student attitudes. So, it is hoped that the Tobasa Health Office will make a work program of health education or a routine schedule of health counseling and to continuously socialize health information about Sadari, especially to schools in Tobasa so that students know and do Realize so they can detect breast cancer early. Abstrak

Penelitian ini bertujuan untuk mengetahui pengaruh pendidikan kesehatan tentang SADARI sebagai deteksi dini kanker payudara terhadap pengetahuan dan sikap siswi SMK Swasta Yapim Kecamatan Balige Kabupaten Tobasamosir Tahun 2020. Penelitian ini merupakan jenis penelitian eksperimen semu atau quasi experiment, menggunakan metode pretest-posttest design, yaitu dengan cara memberikan pre test (pengamatan awal) terlebih dahulu sebelum dilakukan intervensi, setelah diberikan intervensi kemudian dilakukan post test (pengamatan akhir). Penelitian dilaksanakan di SMK Swasta Yapim Kecamatan Balige Kabupaten Toba samosir pada bulan Januari s/d Maret 2020. Subyek penelitian adalah total seluruh Siswi SMK Swasta Yapim Balige yang berjumlah 91 siswi. Uji statistik yang digunakan adalah uji wilcoxon. Hasil analisa uji pair ttest pre test dan post test pengetahuan. Maka, disimpulkan ada pengaruh pendidikan kesehatan tentang SADARI terhadap pengetahuan siswi. Hasil analisa uji pair t-test pre test dan post test sikap diperoleh nilai p = 0.000, berarti nilai p > 0.05. Maka, ada pengaruh pendidikan kesehatan tentang SADARI terhadap sikap siswi. Sehingga, diharapkan kepada Dinas Kesehatan Tobasa untuk membuat program kerja penyuluhan kesehatan atau jadwal rutin penyuluhan kesehatan serta mensosialisasikan informasi kesehatan secara terus menerus tentang Sadari terutama ke sekolah yang ada di Tobasa sehingga siswi mengetahui dan melakukan Sadari sehingga dapat mendeteksi dini kanker payudara.
Factors Affecting Students’ Academic Performance in Higher Education: Evidence from Accountancy Degree Programme
Authors: Hassan Haslinda , Mohamad Rosli , Raja Mohd Ali Raja Haslinda , Abdul Talib Yurita Yakimin , Mohamad Hsbollah Hafizah
Published: July 2021

The increasing demands for accountants in the future have resulted in an increased number of students enrolling in the accounting programmes of Malaysian universities. This expansion, however, has caused some concern about whether these students are likely to succeed in their studies. This study, therefore, aims to examine the factors that drive the academic performance of accounting students at Malaysian universities. The factors included gender, ethnic groups, type of secondary school, sponsorship, and family income. The students’ academic performance was represented by their cumulative grade point average (CGPA) obtained at the end of their programs. The study used a quantitative research design using secondary data of 367 undergraduate accounting students graduated in 2016 from the Universiti Utara Malaysia (UUM) for analysis. The findings suggested that there were significant differences in students’ academic performance related to ethnic groups, type of secondary school, and family income. Specifically, Malay, Indian, and other students performed less well than did Chinese students. Gender and sponsorship, however, had no significant influence on their academic performance. The study’s findings could help higher learning institutions, parents, and policymakers to formulate effective intervention mechanisms and to introduce a more holistic approach to improve student performance.
Board diversity, company’s financial performance and corporate social responsibility information disclosure in Malaysia
Authors: Hassan Lily Suriana , Mohd Saleh Norman , Ibrahim Izani
Published: July 2021

The aim of this study is to investigate the relationship between board diversity, financial performance and disclosure of corporate social responsibility (CSR) information of the Malaysian listed companies. Different from prior literature, board diversity is viewed from the perspective of gender, age, tenure, educational level, professional membership and functional background. We used one explanation i.e. diversity as variety, out of three explanations from a typology in social psychological and organizational management fields. The sample consists of 205 companies listed on Bursa Malaysia. Using regression analysis, a significant positive relationship was noted between the functional backgrounds of directors and the companies’ financial performance. The result shows that boards should have diversity in their functional background. The other forms of board diversity such as gender, age, tenure, educational level and professional membership have been found not to influence companies’ financial performance. Board professional membership diversity was found to significantly increase the CSR information disclosure. However, other forms of board diversity were found not to influence the CSR information disclosure. These findings may suggest that corporate boards should have diversity in their functional background and professional membership in order to enhance companies’ financial performance and CSR information disclosure.
Transformational Leadership and Organizational Change: In The Context of Today’s Leader
Authors: Usman Muliati
Published: July 2021

Today’s leader deals with many challenges in enacting roles as agents of change. Extremely uncertain and rapidly changing in a dynamic environment become a crucial problem for a leader in mobilizing organizational change. It is imperative for a leader to adopt a strategic approach to drive organizational change effectively for establishing organizational improvement and sustainability. This article reviews transformational leadership as an effective model to drive organizational change in the context of today’s organization leader. Although, there is still controversy about the significant leadership style for establishing changes, the results of previous studies have proven that transformational leadership is a specific approach to achieve the success of organizational change in today's environment.
Influenza and cardiorespiratory events: a clinical-epidemiological review with a multidisciplinary point of view
Authors: Carro Hevia Amelia , Sanz Hernández Francisco , Álvarez Aldeán Javier , García Cenoz Manuel , Jimeno Sanz Isabel , Redondo Margüello Esther , Vidán Astiz Mª Teresa , García Rojas Amós ,   Sección de Epidemiología y Prevención, Servicio de Epidemiología y Prevención Dirección General de Salud Pública Servicio Canario de la Salud, Spain
Published: July 2021

There is accumulating evidence showing that influenza infection and cardiorespiratory diseases are closely associated. Influenza has been described as a triggering factor capable of both exacerbate underlying chronic diseases as well as inducing the appearance of new respiratory and cardiovascular events. Consequently, influenza infection and its associated comorbidity have a significant impact on the health system. In this document, we extensively reviewed the current literature to describe the most relevant data on the relationship between influenza infection and cardiorespiratory diseases. Likewise, we analyzed the possible pathophysiological mechanisms explaining the connection between influenza infection and cardiac and respiratory events. Finally, reviewed data has been put into perspective to highlight the importance of influenza vaccination as an effective measure in the prevention of cardiorespiratory diseases, especially in the population with underlying chronic diseases.
Teori Nasakh Mansukh Dalam Penetapan Hukum Syariat Islam
Authors: Muhammad Husni dan Fathul Wahab
Published: July 2021

he existence of nasakh and mansukh in the determination of Islamiclaw is very important, because not always the law in one place is the same as theplace and conditions in other places. It's just that in imposing nasakh andmansukh this is limited to the problems of shar'i law, while other than that it is notpermissible such as the issue of aqidah or the points of worship and moralprinciples, such as justice, honesty, prohibition of shirk, killing, stealing andothers etc .. Besides that, the determination of nasakh and mansukh is notpermitted by using ijtihad or the opinions of the scholars, but it is indeed purefrom Allah Almighty contained in the Qur'an. However, there are two opposinggroups namely those who support the existence of nasakh and mansukh in theQur'an and groups who reject the existence of nasakh and mansukh in the Qur'an.The middle way taken is to compromise the two opposing groups by reviewing theterms understanding nasakh and mansukh. With this compromise, it is hoped thatthere will be no more opposition regarding nasakh and mansukh. For this reasonthe scholars set ways to know nasakh and mansukh strictly. Despite the pros andcons of nasakh and mansukh. Nasakh and mansukh have provided great lessonsfor Muslims including the development of tasyri 'towards the level and the desirefor goodness and convenience for Muslims.
Antisipasi Dampak negatif Penggunaan Smartphone Bagi Siswa kelas XI SMA Negeri 8 Batang Hari Melalui Layanan Bimbingan Kelompok
Authors: Iyut Mardiati
Published: July 2021

Abstract:Smartphones as a medium of communication bringconvenience to humans anywhere in the world to communicate, helpinghumans to shorten the mileage. No need to meet physically, but in theair can exchange information and deliver messages. In particularSmartphone technology is increasingly making human privacy soawake. If it is controlled, the smartphone certainly has a positiveimpact. However, if not, the facilities in the Smartphone can bemisused
Penggunaan Metode Creative Problem Solving (CPS) Dalam Meningkatkan Keterampilan Siswa Pada MataPelajaran Fisika Di SMAN 10 Kota Jambi
Authors: Evi Ramna Farni
Published: July 2021

AbstractStudent at X grade MIPA I in even semester learn about the second motion law that talks about momentum and stylistic changes in physics. The students ' level of knowledge in this material is very low, characterized by the average skills of receiving, analyzing, and operationalizing the second law of motion only 25.42%. In an effort to increase the average of the skills of accepting, analyzing and operationalizing the second motion law, it is necessary to take action by applying the creative problem Solving (CPS) method to the learning activities. The first action on the first sikulus showed the average skills of grade X students I had increased by 17.49%, while on the second cycle increased from
Pengaruh Hafalan Ayat AL-Qur’an terhadap Prestasi Belajar Siswa Mata PelajaranAl-Qur’an Hadits Di Madrasah Ibtidaiyah Al-Azhar Serabi Barat Bangkalan
Authors: Subhan Adi Santoso
Published: July 2021

Abstract education is a basic necessity for every human being, because with the education that human beings can determine the next steps. In this study the authors use a method of survey with a correlation approach conducted in Madrasah Ibtidaiyah Al-Azhar Serabi Barat Bangkalan by involving class III, IV, V and VI students who participated in the memorization activities of the Qur'an. Data collection is done with observations, polls, and documentaries. Data analysis using correlation analysis with product moment formula correlation technique.The results of the research obtained to answer the formulation of problems are: 1) the application of memorization of the Qur'an in Madrasah Ibtidaiyah Al-Azhar Serabi Barat Bangkalan applied according to the results of observation and based on the results of the poll, hence the result obtained is 55.5. Thus, the average score number of the memorization rate of Al-Quran Madrasah Ibtidaiyah Al-Azhar Serabi Barat Bangkalan is good enough, 2) Student learning achievement on the subjects of the Qur'an hadith in Madrasah Ibtidaiyah Al-Azhar Serabi Barat Bangkalan after the memorization activities of the Qur'an is in good category with an average of 81.92 of the entire respondent, and 3) the influence between memorization of Al-Qur'an with students ' learning achievement in the field of Quranic study in Madrasah Ibtidaiyah Al-Azhar Serabi Barat Bangkalan with medium interpretation. With the correlation number between variable X and variable Y of 0511. Its significance by 5% seen from table Correlation Product Moment.