bluuebunny/crossref_metadata_2025 huggingface dataset:
Police Use of Force and Injury: Multilevel Predictors of Physical Harm to Subjects and Officers
Authors: Hickman Matthew J. , Strote Jared N. , Scales Robert M. , Parkin William S. , Collins Peter A.
Published: November 2020

The police must on occasion use physical force and weapons in order to apprehend and control subjects and fulfil the police function. It is inevitable that some of these interactions will result in injuries to both subjects and officers, with a range of both tangible and intangible harms and costs. It is therefore important to study injuries related to the use of force with an eye toward identifying opportunities to minimize injury and reduce the harms and costs. Injuries to both subjects and officers were examined in a sample of more than 10,000 use of force incidents drawn from 81 agencies located in 8 states. In addition to describing injury rates across a broad spectrum of situational and agency characteristics, we present multilevel logistic regression models predicting subject and officer injury. Among key findings, we report that the likelihood of injury for both subjects and officers is lower when force incidents end quickly and with the minimal necessary superior level of force relative to subject resistance, and higher for both subjects and officers when subjects flee. At the agency level, we find that the likelihood of injury varies by agency size and type. Finally, we explored possible higher-level variation and found that agencies in the sample from Midwestern states (primarily Wisconsin) have substantially lower injury rates that appear to be associated with their less frequent use of weapons and greater reliance on low-level physical force tactics, as compared to agencies in the sample from Western and other states.
Wear, optimization and surface analysis of Al-Al2O3-TiO2 hybrid metal matrix composites
Authors: Ahamad Naseem , Mohammad Aas , Sadasivuni Kishor Kumar , Gupta Pallav
Published: November 2020

The aim of the present work is to investigate vickers hardness, wear behavior as well as to perform optimization of wear data for pure Al and Al-Al2O3-TiO2 hybrid metal matrix composites. The hybrid composite (Al-Al2O3-TiO2) was prepared by mechanical stir casting with equal proportion of reinforcement (2.5, 5.0, 7.5 and 10 wt.%). Vickers hardness, wear behavior and its optimization using ANOVA as well as TOPSIS along with the microstructure of the worn surface of prepared sample has been investigated. Vickers hardness increases with an increase in weight percentage of reinforcements. Wear test was carried out under dry sliding condition by pin-on-disc wear machine according to the ASTM G99-95a standard. Wear properties of the sample have been obtained at different percentages of reinforcement. Wear resistance of the hybrid composite increases with the variation of percentage of titanium oxide particles due to its lubricating properties. ANOVA shows that the reinforcements and load have different effect on samples wear rate. TOPSIS analysis shows rank of the sample according to its wear rate. Worn surface morphology was investigated and it showed deep grooves, more debris, delamination and rough surface in pure Al sample as compared to the high percentage of reinforced hybrid metal matrix composites.
Power and International Relations: a temporal view
Authors: Drezner Daniel
Published: November 2020

International Relations scholars are certain about two facts: power is the defining concept of the discipline and there is no consensus about what that concept means. One explanation for this problematic state of the field is that most International Relations scholars freight their analyses of power with hidden assumptions about time. Temporality is an essential component of political analysis, as a burgeoning literature has begun to explore. This paper argues that there are two latent presumptions about time that fundamentally affect how scholars conceptualize power in world politics. First, scholars are rarely explicit in defining the temporal scope of their key causal processes. The longer the implicit temporal scope, the more expansive their definition and operationalization of power can be. Second, there is considerable variation of beliefs about the temporal returns to power: does exercising or accumulating power generate positive or negative feedback effects over time? Relying on canonical works in the field, this paper examines the hidden assumptions that different paradigms make about power and time. Illuminating these assumptions clarifies the root of cross-paradigmatic disagreements about international politics and suggests some interesting pathways for future theoretical and empirical work.
‘Breakthrough’ political science: Multi-level governance – Reconceptualising Europe’s modernised polity
Authors: Jeffery Charlie , Peterson John
Published: November 2020

Multi-level governance has provoked debates over the last quarter century as the thinking of Liesbet Hooghe and Gary Marks has progressed. That thinking has been both innovative and eclectic, forming a number of intellectual ‘story arcs’ that part ways, develop and mature, then recombine with renewed force. We take Hooghe and Marks’ Multi-Level Governance and European Integration as a pivotal moment in the development of that thinking. We then trace the ‘story arcs’ of multi-level governance by pinpointing three questions. Does multi-level governance ‘travel’ as a viable analytical framework much beyond cohesion policy? Does multi-level governance give analytical purchase beyond the European Union? And is multi-level governance merely a descriptive framework or does it embed or give rise to theory? We conclude by shortly summarising the contributions to this Breakthrough Political Science Symposium.
Unthinkable concepts, invisible genealogies: rereading the new materialist rereading of The Second Sex
Authors: Čičigoj Katja
Published: November 2020

In the essay ‘Sexual Differing’ from their book New Materialism: Interviews and Cartographies, Rick Dolphijn and Iris van der Tuin develop their new materialist take on sexual difference through their rereading of Simone de Beauvoir’s The Second Sex. I propose to read this essay as deploying the ‘analytical tool’ of ‘jumping generations’ articulated in the homonymous paper by van der Tuin as signature of the ‘new materialist’ ‘third wave’ of feminist theory. By pointing to the immediate textual context of the passages from The Second Sex quoted in ‘Sexual Differing’, to the philosophical underpinning of Beauvoir's work, and to the historical context of its reception, I argue that while the tool of ‘jumping generations’, as put to use in ‘Sexual Differing’, might produce unexpected outcomes, it also risks confining to dusty feminist archives segments of feminist philosophy that might still be relevant for thinking gendered oppression and liberation today: Beauvoir's understanding of the social ontogenesis of freedom, the collective and egalitarian nature of political transformation and the genealogy of materialist feminist thought theoretically and historically linked to Beauvoir and The Second Sex. The issue is not merely one of historical and theoretical accuracy, but of enabling a capacious materialist analysis of gendered oppression and liberation. I conclude by pointing at how Dolphijn and van der Tuin's approach expressly discards understandings of history and scholarship that it nevertheless necessarily performs, and propose that this can be taken as a starting point to rethink sexual differing in terms of a political and ethical commitment beyond its originary metaphysical new materialist articulation. This is where, I propose, the above-mentioned conceptual resources linked to The Second Sex and muted by ‘Sexual Differing’ could prove fruitful, and timely.
TV adverts, materialism, and children’s self-esteem: The role of socio-economic status
Authors: Nairn Agnes , Opree Suzanna J
Published: November 2020

Levels of debt and poor mental health are at an all-time high among UK families, while the gap between rich and poor has also widened. Exposure and susceptibility to advertising, belief that purchased products will lead to happiness (materialism), and poor mental well-being have been shown to be linked in previous research, but the role of children’s socio-economic status has seldom been taken into account. A greater understanding of the effects of this dynamic among those without the ready money to purchase highly advertised and desired products is important, particularly given the connections with children’s low self-esteem. This study aimed to (1) quantify differences in TV advertising exposure, materialism, and self-esteem between deprived and affluent children, (2) measure differences in susceptibility to the effect of TV advertising exposure on materialism between deprived and affluent children, and (3) measure differences in susceptibility to the effect of materialism on self-esteem between deprived and affluent children. It was found that children from deprived backgrounds were more materialistic than children from affluent homes, and that this was the result of both higher exposure to advertising and higher belief in the credibility of advertising. At the same time, we found that children from affluent backgrounds were more susceptible to advertising’s reinforcing effect on materialism, whereas children from deprived background were more susceptible to materialism’s detrimental effect on self-esteem. Two different dynamics appear to be at play in the two groups. This adds a new dimension to our understanding of the role of advertising in a society with high levels of inequality.
Safety and Long-Term Effect Assessment of Neoadjuvant Chemoradiotherapy for Elderly Patients With Locally Advanced Rectal Cancer: A CHN Single-Center Retrospective Study
Authors: Liu Hengchang , Li Chunxiang , Zhao Zhixun , Guan Xu , Yang Ming , Liu Zheng , Tang Yuan , Jiang Zheng , Wang Xishan
Published: November 2020

Introduction:

Neoadjuvant chemoradiotherapy (nCRT) followed by operation has become the standard treatment for locally advanced rectal cancer (LARC). However, considering the possible toxicity and complications of radiochemotherapy, nCRT is seldom used for the elderly. The purpose of this study was to assess the safety and long-term effect of nCRT combined with TME in elderly patients with LARC.

Method:

Four-hundred-fourteen LARC patients were divided into 2 groups: 108 patients were in the elderly group (≥ 65 years old) and 306 patients were in the non-elderly group (<65 years old). The side effects, toxicity, complications, disease-free survival (DFS), and overall survival (OS) of all of the patients were assessed.

Results:

The data comprised 103 patients in the elderly group and 292 patients in the non-elderly group who completed nCRT sessions following operation. The treatment-completion rates of the elderly and non-elderly groups were 95.37% and 95.42%, respectively. Twenty-two patients developed radiotherapy complications (grade III) in the elderly group and 37 such cases developed in the non-elderly group. Diarrhea, skinulcer, and perianal pain were ranked as the top 3 most common complications. The incidence of infection, anastomotic leakage, and intestinal obstruction was 0.97% in the elderly group. The 5-year DFS and 5-year OS rate were 70.7% and 80.8% in the elderly group, 67.3% and 81.6% in the non-elderly group respectively.

Conclusions:

nCRT are safe and effective for elderly patients, and it does not increase the risk of postoperative complications for the elderly. Hence, nCRT should not be withheld based on age alone.
Development and Validation of a Scoring System Based on 9 Glycolysis-Related Genes for Prognosis Prediction in Gastric Cancer
Authors: Luo Tianqi , Du Yufei , Duan Jinling , Liang Chengcai , Chen Guoming , Jiang Kaiming , Chen Yongming , Chen Yingbo
Published: November 2020

Gastric cancer is a malignant tumor with high morbidity and mortality worldwide. However, increasing evidences have revealed the correlation between the glycolysis process and tumorigenesis. This study is aim to develop a list of glycolysis-related genes for risk stratification in gastric cancer patients. We included 500 patients’ sample data from GSE62254 and GSE26942 datasets, and classified patients into training (n = 350) and testing sets (n = 150) at a ratio of 7: 3. Univariate and multivariate Cox regression analysis were performed to screen genes having prognostic value. Based on HALLMARK gene sets, we identified 9 glycolysis-related genes (BPNT1, DCN, FUT8, GMPPA, GPC3, LDHC, ME2, PLOD2, and UGP2). On the basis of risk score developed by the 9 genes, patients were classified into high- and low-risk groups. The survival analysis showed that the high-risk patients had a worse prognosis ( p < 0.001). Similar finding was observed in the testing cohort and 2 independent cohorts (GSE13861 and TCGA-STAD, all p < 0.001). The multivariate Cox regression analysis showed that the risk score was an independent prognostic factor for overall survival ( p < 0.001). Furthermore, we constructed a nomogram that integrated the risk score and tumor stage, age, and adjuvant chemotherapy. Through comparing the results of the receiver operating characteristic curves and decision curve analysis, we found that the nomogram had a superior predictive accuracy than conventional TNM staging system, suggesting that the risk score combined with other clinical factors (age, tumor stage, and adjuvant chemotherapy) can develop a robust prediction for survival and improve the individualized clinical decision making of the patient.

In conclusion, we identified 9 glycolysis-related genes from hallmark glycolysis pathway. Based on the 9 genes, gastric cancer patients were separated into different risk groups related to survival.
Co-enrolment to UK Critical Care Studies – A 2019 update
Authors: Felton Timothy , Pattison Natalie , Fletcher Simon , Finney Simon , Walsh Tim , Dark Paul
Published: November 2020

In 2013, a group of clinicians on behalf of the National Institute for Health Research, collaborated with ICU Steps to produce guidance about people being enrolled in more than one critical care trial. This is referred to as “co-enrolment” and can be where a person takes part in one study at the same time as another study (or one after the other in a short time-frame). For instance, being part of a study looking at sepsis drugs and a mechanical ventilation weaning study. The drivers for developing this guidance were a lack of any existing guidance, nationally and internationally, at that time, and a desire to ensure high quality research is conducted. The emphasis was on making trials as safe as possible for patients and ensuring robust trial outcomes. Critical care was seen to lead in this, with our exemplar guidance used across all health research. We wish to revisit this guidance now that there is more experience of coenrolment in critical care trials. There is also more awareness of different consent models, such as deferred consent (taking consent when a person is awake and able to give consent) and consultee consent (asking families or independent professionals to consent). Consenting to coenrolment is an important ethical consideration for the revision of this guidance.
Impact of intravenous tranexamic acid on patients undergoing shoulder arthroplasty surgery
Authors: Kissin E , Al-Tawil K , Tavakkolizadeh A , Sinha J , Colegate-Stone T
Published: November 2020

Background

Shoulder arthroplasty surgery carries the risk of blood loss. The antifibrinolytic tranexamic acid (TXA) is effective in reducing blood loss in lower limb arthroplasty. The purpose of this study was to assess blood loss and associated complications following shoulder arthroplasty performed with and without TXA for both elective and trauma indications.

Methods

A cohort study was performed to assess blood loss, transfusion requirements and post-operative venous thromboembolic events (VTE) following shoulder arthroplasty undertaken with and without the use of intravenous TXA.

Results

The study consisted of 67 patients ( n = 36 with TXA; n = 31 without TXA). Type of arthroplasty included reverse-shoulder arthroplasty, total-shoulder arthroplasty and hemiarthroplasty. There was no significant difference between TXA and non-TXA groups regarding blood loss (TXA group haemoglobin drop 20.6 mg/dL; non-TXA group haemoglobin drop 20.5 mg/dL; p = 0.978). There was no significant difference in measured outcomes with or without TXA use for elective or trauma indications, nor regarding type of arthroplasty.

Discussion

The use of intravenous TXA in shoulder arthroplasty was not associated with a significant reduction in blood loss or post-operative transfusion rates, nor did it impact on VTE. This result was not affected by the indication being elective or trauma nor the type of arthroplasty surgery performed.
Neurotoxic Effects of Ammonia in a Patient With Ornithine Transcarbamylase Deficiency and Bilateral Brain Abscesses: Case Report
Authors: Sayyahmelli Sima , Sayyahmelli Sara , Erginoglu Ufuk , Başkaya Mustafa K.
Published: November 2020

Brain abscesses are a rare complication of dental procedures. High concentrations of ammonia in brain abscesses may increase vasogenic edema and other brain abscess symptoms. Ornithine transcarbamylase deficiency (OTCD) is an x-linked genetic disorder of the urea cycle associated with an increased risk of brain damage due to hyperammonia. During acute metabolic decompensations, due to stresses such as infection in OTCD patients, blood ammonia levels become moderately high. This, in turn, causes cerebral glutamine levels to increase and exacerbate cerebral edema and neurological symptoms. In this report, we present a 25-year-old woman with known partial OTCD who presented with bilateral brain abscesses 2 weeks after a wisdom tooth extraction. Neurotoxic effects of ammonia, from local ammonia formation in brain abscesses positive for streptococcus intermedius, or due to her OTCD, may have exacerbated the cerebral edema, which resulted in irreversible encephalopathy that lead to her death.
Do Not Neglect the Power of Symbols on Employee Performance: An Empirical Evidence From Turkey
Authors: Coşar Bora , Uzunçarşili Ülkü , Altindağ Erkut
Published: November 2020

Symbols, which are considered as a reflection of an organization’s culture, also provide clues about an organization’s character and value system. The positioning of symbols in the business world and academic studies thus remains an important issue. This study, which measures the effects of organizational symbolism on organizational commitment and firm performance, carries out a scale development study to evaluate the concept of symbolism. For this analysis, a questionnaire was provided to 727 family-owned business employees. In the scale development section, the organizational symbolism was divided into three dimensions, where it was observed that structural and administrative symbolism, along with outward symbolism, affect organizational commitment and firm performance, although narrative and discursive symbolism do not affect organizational commitment and firm performance. The findings are partially consistent with the current literature. In the “Discussion” section, suggestions are given to academicians and administrators.
Feasibility and Acceptability of a Community-Based Modified Mindfulness-Based Stress Reduction Program for the Under- and Unemployed
Authors: Wasson Rachel S. , Luberto Christina M. , Murthi Meera , McDonald Susan Blocksom , Pallerla Harini , Novak Brenna K. , Cotton Sian
Published: November 2020

Background

Mindfulness-Based Stress Reduction (MBSR) often improves health outcomes, though literature primarily focuses on middle-class, employed individuals. With an estimated average of six million unemployed over the past year, and the recent uptick in unemployment due to the COVID-19 pandemic, it is important to identify methods to mitigate and reduce the negative health outcomes often associated with under- and unemployment.

Objectives

We aimed to 1) outline the process of partnering with a community organization to implement a modified MBSR program for under- and unemployed individuals, and 2) present pilot data on preliminary results.

Methods

The modified MBSR program was implemented in two phases within a job training program for under- and unemployed individuals. In Phase I, group one received an eight-week program. Based on feedback, the MBSR program was reduced to six weeks and implemented for groups two and three (Phase II). Feasibility and acceptability were evaluated utilizing a mixed-methods approach. Changes in mindfulness, perceived stress, pain interference, anxiety, depression, and sleep disturbance were assessed pre-post the modified MBSR program.

Results

Thirty-three participants completed the program with twenty-nine post-survey responses. The modified MBSR program was feasible and acceptable as evidenced by the enrollment rate (96%), retention rate (72%), and qualitative feedback. Fifty-percent of participants self-reported weekly home practice compliance. Perceived stress and mindfulness demonstrated significant moderate improvements ( d =  .69, p =  .005; d =  .46, p =  .001). Depression, anxiety, and pain interference results suggested small non-significant effect size improvements ( d =  .27, p =  .19; d =  .23, p =  .31; d =  .25, p =  .07). Effects on fatigue and sleep disturbance were negligible.

Conclusion

The modified MBSR program was feasible and acceptable to the organization and participants. Small to moderate improvements in mental health and pain interference outcomes were observed. Research using larger sample sizes and randomized designs is warranted.
Contextual Support and Career Aspirations of Working Women
Authors: Kang Lakhwinder Singh , Kaur Gurpreet
Published: November 2020

The purpose of this article was to investigate the impact of career-related support in work and non-work domains on the aspirations of women for progression in career. Using multistage sampling technique, the data were collected from 438 female employees working in private sector banks and insurance companies in Punjab, a state in north India. AMOS-based structural equation modelling was performed, and the results revealed that family/spousal support in non-work domain and supervisory and organisational support in work domain significantly predicted the career aspirations of working women, whereas the impact of collegial support was not observed. Supervisor support was found to be the most significant source of support followed by family/spousal support and then organisational support.

The present study is a pioneer work, which has empirically examined the role of various forms of contextual supports in work and non-work domains in determining the desired aspirations of working women in India. The study proposes that collective efforts on the part of women themselves, their families, supervisors, colleagues and organisations are required to enhance working women’s propensity to aspire and realise their aspirations for advancement in career.
Nepheline solid solution compositions: stoichiometry revisited, reviewed, clarified and rationalised
Authors: Henderson C. Michael B.
Published: November 2020

Molecular formulae used to recalculate nepheline analyses generally have different numbers of oxygens (e.g. NaAlSiO4(Ne), KAlSiO4,(Ks), CaAl2Si2O8(An) and SiO2(Q)). A 32 oxygen cell has 16 T cations and 8 cavity sites, but ideal nepheline stoichiometry is not necessarily followed. Ca end-member □CaCaAl2Si2O4(CaNe) and excess silica end-member □SiSi2O4(Q’) calculation requires inclusion of both vacancy species as cavity cation values. Q’ parameter calculations can involve different assumptions and four parameters are described: Qxs; QSi; Q(Si–Al); and Qcavity; these should have closely similar values for high-quality, stoichiometric analyses.

Representative published compositions are recalculated to assess whether authors followed ideal nepheline stoichiometry. Phenocrysts from peralkaline rocks and nephelinites typically exhibit Al deficiencies reflected in negative Δ(Al – cavity cation) parameters (ΔAlcc), negative ‘normative’ corundum (Al2O3,Cn), and anomalously low or negative Qxsparameters; for such rock types Q(Si–Al)provides a better estimate of excess silica contents. A ΔT-site (cation charge) parameter (ΔTcharge), is closely coupled to ΔAlccand end-member NaAlSiO4has a ΔAlcc/ΔTchargeratio of 1.4296; the derivation of this value is controlled by strict stuffed-tridymite, unit-cell constraints. Natural nephelines all contain excess silica with a mean ΔAlcc/ΔTchargeof ~1.134 reflecting their Si/Al ratio being > 1.

Nepheline analyses with relatively low Al and Si and high Na (also Ca) contents are common; this might reflect the presence of small amounts (up to ~5%) of cancrinite as an alteration phase or perhaps even in solid solution. The compositions of alteration lamellae of Ca-rich cancrinite in altered nepheline phenocrysts in phonolites from the Marangudzi alkaline complex, Zimbabwe, are used to define diagnostic parameters for recognising such non-stoichiometry. These alteration lamellae formed hydrothermally from Ca-rich and K-poor fluids.

An EXCEL file is provided to help researchers to standardise calculation of nepheline end-member molecular proportions.
FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia
Authors: Govindarajah Vinothini , Lee Jung-Mi , Solomon Michael , Goddard Bryan , Nayak Ramesh , Nattamai Kalpana , Geiger Hartmut , Salomonis Nathan , Cancelas Jose A. , Reynaud Damien
Published: November 2020

Hematopoietic stem cell (HSC) activity is tightly controlled to ensure the integrity of the hematopoietic system during the organism’s lifetime. How the HSC compartment maintains its long-term fitness in conditions of chronic stresses associated with systemic metabolic disorders is poorly understood. In this study, we show that obesity functionally affects the long-term function of the most immature engrafting HSC subpopulation. We link this altered regenerative activity to the oxidative stress and the aberrant constitutive activation of the AKT signaling pathway that characterized the obese environment. In contrast, we found minor disruptions of the HSC function in obese mice at steady state, suggesting that active mechanisms could protect the HSC compartment from its disturbed environment. Consistent with this idea, we found that FOXO proteins in HSCs isolated from obese mice become insensitive to their normal upstream regulators such as AKT, even during intense oxidative stress. We established that hyperglycemia, a key condition associated with obesity, is directly responsible for the alteration of the AKT-FOXO axis in HSCs and their abnormal oxidative stress response. As a consequence, we observed that HSCs isolated from a hyperglycemic environment display enhanced resistance to oxidative stress and DNA damage. Altogether, these results indicate that chronic metabolic stresses associated with obesity and/or hyperglycemia affect the wiring of the HSCs and modify their oxidative stress response. These data suggest that the uncoupling of FOXO from its environmental regulators could be a key adaptive strategy that promotes the survival of the HSC compartment in obesity.
Efficacy and safety of carfilzomib-based regimens in frail patients with relapsed and/or refractory multiple myeloma
Authors: Facon Thierry , Niesvizky Ruben , Mateos Maria-Victoria , Siegel David , Rosenbaum Cara , Bringhen Sara , Weisel Katja , Ho P. Joy , Ludwig Heinz , Kumar Shaji , Wang Kenneth , Obreja Mihaela , Yang Zhao , Klippel Zandra , Mezzi Khalid , Goldrick Amanda , Tekle Christina , Dimopoulos Meletios A.
Published: November 2020

Frailty is most prevalent among elderly multiple myeloma (MM) patients, and frail patients have a higher risk of poor outcomes due to reduced performance status or comorbidities. This post hoc analysis assessed efficacy and safety of carfilzomib combinations in frail patients with relapsed and/or refractory MM from the phase 3 ASPIRE (carfilzomib [27 mg/m2]-lenalidomide-dexamethasone [KRd27] vs lenalidomide-dexamethasone [Rd]), ENDEAVOR (carfilzomib [56 mg/m2]-dexamethasone [Kd56] vs bortezomib-dexamethasone [Vd]), and ARROW (once-weekly carfilzomib [70 mg/m2]-dexamethasone [Kd70] vs carfilzomib [27 mg/m2]-dexamethasone [Kd27]) studies. A frailty algorithm incorporating age, Charlson comorbidity index, and performance status classified patients as fit, intermediate, or frail. Results are presented for frail patients (ASPIRE, n = 196; ENDEAVOR, n = 330; ARROW, n = 141). In ASPIRE, median progression-free survival (PFS) (hazard ratio; 95% confidence interval) was 24.1 (KRd27) vs 15.9 months (Rd) (0.78; 0.54-1.12); median overall survival (OS) was 36.4 vs 26.2 months (0.79; 0.57-1.08). In ENDEAVOR, median PFS was 18.7 (Kd56) vs 6.6 months (Vd) (0.50; 0.36-0.68); median OS was 33.6 vs 21.8 months (0.75; 0.56-1.00). In ARROW, median PFS was 10.3 (once-weekly Kd70) vs 6.6 months (twice-weekly Kd27) (0.76; 0.49-1.16). In all 3 studies, rates of grade ≥3 treatment-emergent adverse events were consistent with those observed in the primary studies. The ASPIRE, ENDEAVOR, and ARROW primary analyses demonstrated favorable benefit-risk profiles with carfilzomib-containing regimens compared with controls. Across clinically relevant subgroups, including those by frailty status, consistent efficacy and safety were observed with KRd27, Kd56, and weekly Kd70, and treatment with these regimens should not be restricted by frailty status.
Gender differences in question-asking at the 2019 American Society of Hematology Annual Meeting
Authors: Moazzam Saira , Onstad Lynn , O’Leary Heather , Marshall Ariela , Osunkwo Ifeyinwa , Du Emily , Dunn Tamara , Dunlap Julianne , Reed Bill , Luger Selina , Lee Stephanie J.
Published: November 2020

Attendance at professional conferences is an important component of career development, because conferences are a major forum for presenting new research, interacting with colleagues and networking. An extensive literature documents differences in the professional experiences of women and men, including experiences at professional conferences. We hypothesized that women are less likely than men to ask questions at conferences, thus forgoing opportunities for professional development. To address this issue, we analyzed the question-asking behavior of women and men at the 2019 Annual Meeting and Exposition of the American Society of Hematology. In all, 112 sessions (55% of those eligible) were randomly chosen for coding, yielding data on 577 presentations. Although approximately 50% of moderators and speakers were women, the proportion of questions asked by women was significantly lower compared with the estimated proportion of women attending the conference (23% vs 39%; P < .0001). Women were more likely to ask questions if another woman asked the first question or if the session topic was red cells. These results suggest that although women are represented equally as moderators and speakers, they are less likely to engage in the postpresentation discourse by asking questions. Encouraging women to speak up in professional situations and providing training on question-asking skills can help address this gender gap that potentially contributes to disparities in professional visibility and career advancement for women in hematology.
Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome
Authors: Pecze Laszlo , Randi Elisa B. , Szabo Csaba
Published: November 2020

Clinical observations and preclinical studies both suggest that Down syndrome (DS) may be associated with significant metabolic and bioenergetic alterations. However, the relevant scientific literature has not yet been systematically reviewed. The aim of the current study was to conduct a meta-analysis of metabolites involved in bioenergetics pathways in DS to conclusively determine the difference between DS and control subjects. We discuss these findings and their potential relevance in the context of pathogenesis and experimental therapy of DS. Articles published before July 1, 2020, were identified by using the search terms “Down syndrome” and “metabolite name” or “trisomy 21” and “metabolite name”. Moreover, DS-related metabolomics studies and bioenergetics literature were also reviewed. 41 published reports and associated databases were identified, from which the descriptive information and the relevant metabolomic parameters were extracted and analyzed. Mixed effect model revealed the following changes in DS: significantly decreased ATP, CoQ10, homocysteine, serine, arginine and tyrosine; slightly decreased ADP; significantly increased uric acid, succinate, lactate and cysteine; slightly increased phosphate, pyruvate and citrate. However, the concentrations of AMP, 2,3-diphosphoglycerate, glucose, and glutamine were comparable in the DS vs. control populations. We conclude that cells of subjects with DS are in a pseudo-hypoxic state: the cellular metabolic and bio-energetic mechanisms exhibit pathophysiological alterations that resemble the cellular responses associated with hypoxia, even though the supply of the cells with oxygen is not disrupted. This fundamental alteration may be, at least in part, responsible for a variety of functional deficits associated with DS, including reduced exercise difference, impaired neurocognitive status and neurodegeneration.
Research on feeder network design: a case study of feeder service for the port of Kotka
Authors: Lin Yisong , Wang Xuefeng , Hu Hao , Zhao Hui
Published: November 2020

By exemplifying the feeder service for the port of Kotka, this study proposed a multi-objective optimization model for feeder network design. Innovative for difference from the single-objective evaluation system, the objective of feeder network design was proposed to include single allocation cost, intra-Europe cargo revenue, equipment balance, sailing cycle, allocation utilization, service route competitiveness, and stability. A three-stage control system was presented, and numerical experiment based on container liner’s real life data was conducted to verify the mathematical model and the control system. The numerical experiment revealed that the three-stage control system is effective and practical, and the research ideas had been applicable with satisfactory effect.
Gene flow between diploid and tetraploid junipers - two contrasting evolutionary pathways in two Juniperus populations
Authors: Farhat Perla , Siljak-Yakovlev Sonja , Valentin Nicolas , Fabregat Carlos , Lopez-Udias Silvia , Salazar-Mendias Carlos , Altarejos Joaquín , Adams Robert P.
Published: November 2020

Background

Gene flow and polyploidy have been found to be important inJuniperusevolution. However, little evidence has been published elucidating the association of both phenomena in juniper taxa in the wild. Two main areas were studied in Spain (Eastern Iberian Range and Sierra de Baza) with both diploid and tetraploid taxa present in sympatry. Gene flow and ploidy level were assessed for these taxa and the resulted offspring.

Results

Twenty-two allo-triploid hybrids betweenJ. sabinavar.sabinaandJ. thuriferawere found in the Eastern Iberian Range population. However, in the Sierra de Baza population no triploids were found. Instead, 18 allo-tetraploid hybrids between two tetraploid taxa:J. sabinavar.balkanensisandJ. thuriferawere discovered. High genetic diversity was exhibited among the tetraploid hybrids at Sierra de Baza, in contrast to the genetically identical triploid hybrids at the Eastern Iberian Range; this suggests meiotic difficulties within the triploid hybrids. In addition, unidirectional gene flow was observed in both studied areas.

Conclusion

Polyploidy and hybridization can be complementary partners in the evolution ofJuniperustaxa in sympatric occurrences.Juniperuswas shown to be an ideal coniferous model to study these two phenomena, independently or in concert.
Stool microbiome, pH and short/branched chain fatty acids in infants receiving extensively hydrolyzed formula, amino acid formula, or human milk through two months of age
Authors: Kok Car Reen , Brabec Bradford , Chichlowski Maciej , Harris Cheryl L. , Moore Nancy , Wampler Jennifer L. , Vanderhoof Jon , Rose Devin , Hutkins Robert
Published: November 2020

Background

Early infant feeding with intact or extensively hydrolyzed (EH) proteins or free amino acids (AA) may differentially affect intestinal microbiota composition and immune reactivity. This multicenter, double-blind, controlled, parallel-group, pilot study compared stool microbiota from Baseline (1–7 days of age) up to 60 days of age in healthy term infants who received mother’s own milk (assigned to human milk [HM] reference group) (n = 25) or were randomized to receive one of two infant formulas: AA-based (AAF;n = 25) or EH cow’s milk protein (EHF;n = 28). Stool samples were collected (Baseline, Day 30, Day 60) and 16S rRNA genes were sequenced. Alpha (Shannon, Simpson, Chao1) and beta diversity (Bray Curtis) were analyzed. Relative taxonomic enrichment and fold changes were analyzed (Wilcoxon, DESEq2). Short/branched chain fatty acids (S/BCFA) were quantified by gas chromatography. Mean S/BCFA and pH were analyzed (repeated measures ANOVA).

Results

At baseline, alpha diversity measures were similar among all groups; however, both study formula groups were significantly higher versus the HM group by Day 60. Significant group differences in beta diversity at Day 60 were also detected, and study formula groups were compositionally more similar compared to HM. The relative abundance ofBifidobacteriumincreased over time and was significantly enriched at Day 60 in the HM group. In contrast, a significant increase in members of Firmicutes for study formula groups were detected at Day 60 along with butyrate-producing species in the EHF group. Stool pH was significantly higher in the AAF group at Days 30 and 60. Butyrate increased significantly from Baseline to Day 60 in the EHF group and was significantly higher in study formula groups vs HM at Day 60. Propionate was also significantly higher for EHF and AAF at Day 30 and AAF at Day 60 vs HM. Total and individual BCFA were higher for AAF and EHF groups vs HM through Day 60.

Conclusions

Distinct patterns of early neonatal microbiome, pH, and microbial metabolites were demonstrated for infants receiving mother’s own milk compared to AA-based or extensively hydrolyzed protein formula. Providing different sources of dietary protein early in life may influence gut microbiota and metabolites.

Trial registration

ClinicalTrials.gov Identifier:NCT02500563. Registered July 28, 2015.
ZBTB7A functioned as an oncogene in colorectal cancer
Authors: Wang Li , Zhang Meng-Xia , Zhang Mei-Fang , Tu Zi-Wei
Published: November 2020

Background

Despite zinc finger and BTB domain-containing 7A (ZBTB7A) documented importance in multiple tumors, the function and clinical value in Colorectal cancer (CRC) remain elusive. The aim of this study was to evaluate the functional roles and the clinical value of ZBTB7A in CRC progression.

Methods

The level of ZBTB7A was detected in a large cohort of CRC patients (n = 189) by immunohistochemistry (IHC), and we analyzed the diagnostic and prognostic value of the protein. In addition, the functional roles of ZBTB7A on CRC were explored in vitro and in vivo.

Results

Survival analyses indicated that patients with high ZBTB7A expression made the prognosis worse (P = 0.024). Functionally, knockdown of ZBTB7A could markedly inhibit tumor proliferation in vitro and in vivo, whereas ZBTB7A overexpression displayed the opposite results.

Conclusions

ZBTB7A was associated with poor survival outcomes and functioned as an oncogene in CRC patients, indicating that it is a potential prognostic biomarker and therapeutic target for CRC patients.
Education interventions for health professionals on falls prevention in health care settings: a 10-year scoping review
Authors: Shaw L. , Kiegaldie D. , Farlie M. K.
Published: November 2020

Background

Falls in hospitals are a major risk to patient safety. Health professional education has the potential to be an important aspect of falls prevention interventions. This scoping review was designed to investigate the extent of falls prevention education interventions available for health professionals, and to determine the quality of reporting.

Method

A five stage scoping review process was followed based on Arksey and O’Malley’s framework and refined by the Joanna Briggs Institute Methodology for JBI Scoping Reviews. Five online databases identified papers published from January 2008 until May 2019. Papers were independently screened by two reviewers, and data extracted and analysed using a quality reporting framework.

Results

Thirty-nine publications were included. Interventions included formal methods of educational delivery (for example, didactic lectures, video presentations), interactive learning activities, experiential learning, supported learning such as coaching, and written learning material. Few studies employed comprehensive education design principles. None used a reporting framework to plan, evaluate, and document the outcomes of educational interventions.

Conclusions

Although health professional education is recognised as important for falls prevention, no uniform education design principles have been utilised in research published to date, despite commonly reported program objectives. Standardised reporting of education programs has the potential to improve the quality of clinical practice and allow studies to be compared and evaluated for effectiveness across healthcare settings.
Management of urinary tract infections: what do doctors recommend and patients do? An observational study in German primary care
Authors: Gágyor Ildikó , Strube-Plaschke Stephanie , Rentzsch Katrin , Himmel Wolfgang
Published: November 2020

Background

Uncomplicated urinary tract infections (UTIs) in women are usually managed in primary care with antibiotics. However, many women seem to prefer to handle UTI symptoms with nonsteroidal anti-inflammatory drugs (NSAIDs) and other remedies. The aim of this study was to compare UTI management as recommended by physicians with the patients’ management at home.

Methods

This prospective cohort study in German primary care is based on clinical data from local practices and patient questionnaires. Participating women completed a baseline data sheet in the practice; their urine sample was tested by a dipstick in the practice and cultured by a laboratory. The women reported treatment and symptom-related impairment on an eight-item symptom questionnaire daily for 7 days. Using growth curve models, we analysed the influence of time on the total severity score to examine how symptoms changed across days. We then examined whether symptom severity and symptom course differed between patients who took antibiotics or NSAIDs.

Results

A total of 120 women (mean age of 43.3 ± 16.6 years) were enrolled. The urine dipstick was positive for leucocytes in 92%, erythrocytes in 87%, and nitrites in 23%. Physicians prescribed antibiotics for 102 (87%) women and recommended NSAIDs in 14 cases. According to the women’s reports, only 60% (72/120) took antibiotics, while the remainder took NSAIDs and other remedies. Symptoms declined from day 0 to day 6, irrespective of whether women decided to take an antibiotic, NSAIDs, none or both, as confirmed by a significant curvilinear time effect (B = 0.06, SE = 0.005, p < .001). The symptom course, however, was moderated by taking antibiotics so that the change in symptom severity was somewhat more pronounced in women taking antibiotics (B = 0.06) than in the remainder (B = 0.04).

Conclusion

A substantial proportion of women did not follow their physicians’ treatment recommendations, and many used NSAIDs. All women had a good chance of recovery irrespective of whether they decided to take antibiotics. A sensitive listening to patient preferences in the consultation may encourage physicians to recommend and prescribe symptomatic treatment with NSAID more often than antibiotic medicines.
Self-perceived postural balance correlates with postural balance and anxiety during the first year after stroke: a part of the randomized controlled GOTVED study
Authors: Rafsten Lena , Danielsson Anna , Sunnerhagen Katharina S.
Published: November 2020

Background

Postural balance is an important rehabilitation outcome, and screening stroke patients for confidence in postural balance during rehabilitation and before hospital discharge is recommended. Early supported discharge could improve postural balance self-confidence.

This study aimed to investigate associations between patient self-confidence in postural balance and observer-assessed postural balance and anxiety during the first year after stroke. Whether very early supported discharge (VESD) affects self-confidence in postural balance compared with standard discharge was also evaluated.

Methods

A longitudinal trial for with data extracted from a randomized controlled study of 140 adults with confirmed stroke was conducted. The experimental group received VESD. The control group was discharged according to the standard routine. Postural balance was assessed with Berg Balance Scale (BBS), Timed Up and Go (TUG) test, and Falls Efficacy Scale. Anxiety was assessed with the Hospital Anxiety and Depression Scale. Spearman’s rank correlation coefficient (rho) was used to test associations between independent variables. The Wilcoxon signed-rank test was used to examine differences over time. A single test, according to Eid, Gollwitzer, and Schmidt, was used to test temporal differences in correlation.

Results

The correlation between self-confidence in postural balance and observer-assessed postural balance was 0.62–0.78 in the first year after stroke. The correlation between self-confidence and anxiety was 0.22–0.41 in the first year after stroke. Correlations did not differ by group affiliation at any time point when the postural balance was assessed with BBS. The intervention group had a significantly higher correlation (r = − 0.709) than the control group (r = − 0.416) when postural balance was assessed with the TUG test 1 month after discharge. There were no significant differences in correlations between confidence in postural balance and anxiety between the two groups at any time point.

Conclusions

Patients with mild stroke can accurately assess their confidence in performing daily activities without falling. VESD does not substantially affect the correlation between self-confidence in postural balance and observer assessed postural balance and is safe to use as an alternative to standard discharge. Assessment of self-confidence can provide important information for rehabilitation planning and supporting the physical activity of patients after discharge.

Trial registration

Clinical Trials.gov: NCT01622205. Registered 19 June 2012 (retrospectively registered).