bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?
Authors: Ruggiero Melania , Calvello Rosa , Porro Chiara , Messina Giovanni , Cianciulli Antonia , Panaro Maria Antonietta
Published: October 2022

In recent years, there has been considerable research showing that coffee consumption seems to be beneficial to human health, as it contains a mixture of different bioactive compounds such as chlorogenic acids, caffeic acid, alkaloids, diterpenes and polyphenols. Neurodegenerative diseases (NDs) are debilitating, and non-curable diseases associated with impaired central, peripheral and muscle nervous systems. Several studies demonstrate that neuroinflammation mediated by glial cells—such as microglia and astrocytes—is a critical factor contributing to neurodegeneration that causes the dysfunction of brain homeostasis, resulting in a progressive loss of structure, function, and number of neuronal cells. This happens over time and leads to brain damage and physical impairment. The most known chronic NDs are represented by Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). According to epidemiological studies, regular coffee consumption is associated with a lower risk of neurodegenerative diseases. In this review, we summarize the latest research about the potential effects of caffeine in neurodegenerative disorders prevention and discuss the role of controlled caffeine delivery systems in maintaining high plasma caffeine concentrations for an extended time.
An Overview of PRR- and NLR-Mediated Immunities: Conserved Signaling Components across the Plant Kingdom That Communicate Both Pathways
Authors: Ramírez-Zavaleta Candy Yuriria , García-Barrera Laura Jeannette , Rodríguez-Verástegui Lizette Liliana , Arrieta-Flores Daniela , Gregorio-Jorge Josefat
Published: October 2022

Cell-surface-localized pattern recognition receptors (PRRs) and intracellular nucleotide-binding domain and leucine-rich repeat receptors (NLRs) are plant immune proteins that trigger an orchestrated downstream signaling in response to molecules of microbial origin or host plant origin. Historically, PRRs have been associated with pattern-triggered immunity (PTI), whereas NLRs have been involved with effector-triggered immunity (ETI). However, recent studies reveal that such binary distinction is far from being applicable to the real world. Although the perception of plant pathogens and the final mounting response are achieved by different means, central hubs involved in signaling are shared between PTI and ETI, blurring the zig-zag model of plant immunity. In this review, we not only summarize our current understanding of PRR- and NLR-mediated immunities in plants, but also highlight those signaling components that are evolutionarily conserved across the plant kingdom. Altogether, we attempt to offer an overview of how plants mediate and integrate the induction of the defense responses that comprise PTI and ETI, emphasizing the need for more evolutionary molecular plant–microbe interactions (EvoMPMI) studies that will pave the way to a better understanding of the emergence of the core molecular machinery involved in the so-called evolutionary arms race between plants and microbes.
Exploration of Tools for the Interpretation of Human Non-Coding Variants
Authors: Tabarini Nicole , Biagi Elena , Uva Paolo , Iovino Emanuela , Pippucci Tommaso , Seri Marco , Cavalli Andrea , Ceccherini Isabella , Rusmini Marta , Viti Federica
Published: October 2022

The advent of Whole Genome Sequencing (WGS) broadened the genetic variation detection range, revealing the presence of variants even in non-coding regions of the genome, which would have been missed using targeted approaches. One of the most challenging issues in WGS analysis regards the interpretation of annotated variants. This review focuses on tools suitable for the functional annotation of variants falling into non-coding regions. It couples the description of non-coding genomic areas with the results and performance of existing tools for a functional interpretation of the effect of variants in these regions. Tools were tested in a controlled genomic scenario, representing the ground-truth and allowing us to determine software performance.
Research Progress on Graphitic Carbon Nitride/Metal Oxide Composites: Synthesis and Photocatalytic Applications
Authors: Lin Hao , Xiao Yao , Geng Aixia , Bi Huiting , Xu Xiao , Xu Xuelian , Zhu Junjiang
Published: October 2022

Although graphitic carbon nitride (g-C3N4) has been reported for several decades, it is still an active material at the present time owing to its amazing properties exhibited in many applications, including photocatalysis. With the rapid development of characterization techniques, in-depth exploration has been conducted to reveal and utilize the natural properties of g-C3N4 through modifications. Among these, the assembly of g-C3N4 with metal oxides is an effective strategy which can not only improve electron–hole separation efficiency by forming a polymer–inorganic heterojunction, but also compensate for the redox capabilities of g-C3N4 owing to the varied oxidation states of metal ions, enhancing its photocatalytic performance. Herein, we summarized the research progress on the synthesis of g-C3N4 and its coupling with single- or multiple-metal oxides, and its photocatalytic applications in energy production and environmental protection, including the splitting of water to hydrogen, the reduction of CO2 to valuable fuels, the degradation of organic pollutants and the disinfection of bacteria. At the end, challenges and prospects in the synthesis and photocatalytic application of g-C3N4-based composites are proposed and an outlook is given.
Molecular and Functional Characterization of BDNF-Overexpressing Human Retinal Pigment Epithelial Cells Established by Sleeping Beauty Transposon-Mediated Gene Transfer
Authors: Mattern Larissa , Otten Katrin , Miskey Csaba , Fuest Matthias , Izsvák Zsuzsanna , Ivics Zoltán , Walter Peter , Thumann Gabriele , Johnen Sandra
Published: October 2022

More and more patients suffer from multifactorial neurodegenerative diseases, such as age-related macular degeneration (AMD). However, their pathological mechanisms are still poorly understood, which complicates the development of effective therapies. To improve treatment of multifactorial diseases, cell-based gene therapy can be used to increase the expression of therapeutic factors. To date, there is no approved therapy for dry AMD, including late-stage geographic atrophy. We present a treatment option for dry AMD that transfers the brain-derived neurotrophic factor (BDNF) gene into retinal pigment epithelial (RPE) cells by electroporation using the plasmid-based Sleeping Beauty (SB) transposon system. ARPE-19 cells and primary human RPE cells were co-transfected with two plasmids encoding the SB100X transposase and the transposon carrying a BDNF transcription cassette. We demonstrated efficient expression and secretion of BDNF in both RPE cell types, which were further increased in ARPE-19 cell cultures exposed to hydrogen peroxide. BDNF-transfected cells exhibited lower apoptosis rates and stimulated neurite outgrowth in human SH-SY5Y cells. This study is an important step in the development of a cell-based BDNF gene therapy that could be applied as an advanced therapy medicinal product to treat dry AMD or other degenerative retinal diseases.
Influence of the Lithium Cation Desolvation Process at the Electrolyte/Electrode Interface on the Performance of Lithium Batteries
Authors: Yarmolenko Olga V. , Baymuratova Guzaliya R. , Khatmullina Kyunsylu G. , Tulibayeva Galiya Z. , Yudina Alena V. , Savinykh Tatiana A. , Yakushchenko Igor K. , Troshin Pavel A. , Shestakov Alexander F.
Published: October 2022

The article considers the effect of the solvate environment of the lithium cation in various aprotic solvents.The redox reactions of electrodes made from a polymeric condensation product of triquinoyl with 1,2,4,5-tetraaminobenzene are studied. A 1 M LiPF6 solution was used as an electrolyte, in either ethylene carbonate/dimethyl carbonate (EC/DMC) or tetraglyme. Based on the electrochemical studies and quantum chemical modeling, it was shown that the desolvation of lithium cations in the tetraglyme-based electrolyte makes it possible to obtain a capacity close to the theoretical one (up to 546 mAh g−1) and only 125 mAh g−1 for the EC/DMC electrolyte. This decrease is due to the fact that the lithium cation adds to the functional groups of the organic material with two dimethyl carbonate molecules, as well as the PF6− anion.
Understanding the Catalytic Deactivation upon Hydrothermal Aging at 850 °C of WO3/Fe-Cu-ZSM-5 Catalyst for Selective Catalytic Reduction of NO by NH3
Authors: Jouini Houda , de Marcos-Galán Alessandra , Mejri Imène , Bensouilah Rahma , Mhamdi Mourad , Blasco Teresa , Delahay Gérard
Published: October 2022

A WO3/Fe-Cu-ZSM-5 catalyst was prepared using the solid state ion exchange method (SSIE) and its performance for the Selective Catalytic Reduction of NO with NH3 (NH3-SCR of NO) was investigated. The study shows that the tungsten addition can slightly improve the high temperature catalytic activity of Fe-Cu-ZSM-5. The influence of hydrothermal aging at 850 °C for 5 h on the structural and textural properties of WO3/Fe-Cu-ZSM-5 was also studied in this paper. The XRD and FE-SEM measurements did not indicate a breakdown of the zeolite structure upon steam treatment for both aged catalysts. The aged W-base catalyst demonstrates a lower deactivation and better catalytic activity for NO reduction than the bimetallic catalyst after hydrothermal aging despite the lower acidic properties as shown by FTIR-Pyr spectroscopy owing to the presence of tungsten oxide crystallites. The “severe” stage of aging occurring in the absence of W led to the formation of copper oxide agglomerates detected using STEM and H2-TPR techniques being responsible for the deterioration of SCR activity of the aged Fe-Cu-ZSM-5.
Impact of Temperature Change on the Fall Armyworm, Spodoptera frugiperda under Global Climate Change
Authors: Yan Xiao-Rui , Wang Zhen-Ying , Feng Shi-Qian , Zhao Zi-Hua , Li Zhi-Hong
Published: October 2022

The fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith, 1797), known as an important agricultural pest around the world, is indigenous to the tropical–subtropical regions in the Western Hemisphere, although its distribution has expanded over large parts of America, Africa, Asia and Oceania in the last few years. The pest causes considerable costs annually coupled with its strong invasion propensity. Temperature is identified as the dominant abiotic factor affecting herbivorous insects. Several efforts have reported that temperature directly or indirectly influences the geographic distribution, phenology and natural enemies of the poikilothermal FAW, and thus may affect the damage to crops, e.g., the increased developmental rate accelerates the intake of crops at higher temperatures. Under some extreme temperatures, the FAW is likely to regulate various genes expression in response to environmental changes, which causes a wider viability and possibility of invasion threat. Therefore, this paper seeks to review and critically consider the variations of developmental indicators, the relationships between the FAW and its natural enemies and the temperature tolerance throughout its developmental stage at varying levels of heat/cold stress. Based on this, we discuss more environmentally friendly and economical control measures, we put forward future challenges facing climate change, we further offer statistical basics and instrumental guidance significance for informing FAW pest forecasting, risk analyses and a comprehensive management program for effective control globally.
Management of Traumatic Brain Injury in Patients with DOAC Therapy–Are the “New” Oral Anticoagulants Really Safer?
Authors: Antoni Anna , Wedrich Lukas , Schauperl Martin , Höchtl-Lee Leonard , Sigmund Irene K. , Gregori Markus , Leitgeb Johannes , Schwendenwein Elisabeth , Hajdu Stefan
Published: October 2022

(1) Background: In recent years, “new” direct oral anticoagulants (DOAC) have gradually replaced other antithrombotic therapies. The international literature agrees on the increased mortality for traumatic brain injury (TBI) patients using vitamin K antagonists (VKA), but thus far, there are insufficient data on the influence of DOAC on the outcome of TBI. (2) Methods: We retrospectively analyzed data from all patients who presented with head trauma using antithrombotic therapy. Outcome parameters were the presence of pathologies on the initial CT, occurrence of delayed intracranial hemorrhage, surgical intervention, and death. (3) Results: In total, data of 1169 patients were reviewed. Of those, 1084 (92.7%) had a mild TBI, 67 (5.7%) moderate TBI, and 17 (1.5%) severe TBI. In total, 456 patients (39%) used DOAC and 713 patients (61%) used VKA, antiplatelet therapy, or prophylactic doses of low molecular weight heparin at the time of trauma. The groups showed no significant differences in age, injury mechanisms, or GCS at presentation. Overall, the initial cranial CT showed pathologies in 85 patients (7.3%). Twenty-five patients with head trauma and DOAC therapy had pathological findings on CT (5.5%), 11 patients with VKA (4.8%), and 48 patients with antiplatelet therapy (10.6%). There was a statistically significant difference in occurrence of CT pathologies between DOAC alone compared to acetylsalicylic acid (4.9 vs. 10.5%, p = 0.04). Delayed intracranial hemorrhage after an initially negative CT during in-hospital observation occurred in one patient (0.2%) in the DOAC group, two patients (0.9%) in the VKA group, and four patients (0.9%) in the antiplatelet group without statistical significance. Head trauma related surgery was performed in three patients (0.7%) in the DOAC group, two patients (0.9%) in the VKA group, and six patients (1.3%) in the antiplatelet group without statistical significance. Death due to head trauma occurred in four patients (0.9%) of the DOAC group compared to one patient (0.4%) of the VKA group and five patients (1.1%) of the antiplatelet group without statistical significance. (4) Conclusions: Our data suggest a comparable risk of pathological CT findings, delayed intracranial hemorrhage, surgical interventions, and death after blunt head trauma for patients with DOAC compared to VKA, but a lower risk for pathological CT findings compared to platelet inhibitors. As VKA are known to increase mortality, our data suggest that similar caution should be used when treating patients with head trauma and DOAC, but the overall numbers of serious or severe courses after simple falls remain low. We recommend routine CT for all head trauma patients with antithrombotic therapy but the role of in-hospital observation for patients with mild TBI remains a matter of debate.
SARS-CoV-2—The Role of Natural Immunity: A Narrative Review
Authors: Diani Sara , Leonardi Erika , Cavezzi Attilio , Ferrari Simona , Iacono Oriana , Limoli Alice , Bouslenko Zoe , Natalini Daniele , Conti Stefania , Mantovani Mauro , Tramonte Silvano , Donzelli Alberto , Serravalle Eugenio
Published: October 2022

Background: Both natural immunity and vaccine-induced immunity to COVID-19 may be useful to reduce the mortality/morbidity of this disease, but still a lot of controversy exists. Aims: This narrative review analyzes the literature regarding these two immunitary processes and more specifically: (a) the duration of natural immunity; (b) cellular immunity; (c) cross-reactivity; (d) the duration of post-vaccination immune protection; (e) the probability of reinfection and its clinical manifestations in the recovered patients; (f) the comparisons between vaccinated and unvaccinated as to the possible reinfections; (g) the role of hybrid immunity; (h) the effectiveness of natural and vaccine-induced immunity against Omicron variant; (i) the comparative incidence of adverse effects after vaccination in recovered individuals vs. COVID-19-naïve subjects. Material and Methods: through multiple search engines we investigated COVID-19 literature related to the aims of the review, published since April 2020 through July 2022, including also the previous articles pertinent to the investigated topics. Results: nearly 900 studies were collected, and 246 pertinent articles were included. It was highlighted that the vast majority of the individuals after suffering from COVID-19 develop a natural immunity both of cell-mediated and humoral type, which is effective over time and provides protection against both reinfection and serious illness. Vaccine-induced immunity was shown to decay faster than natural immunity. In general, the severity of the symptoms of reinfection is significantly lower than in the primary infection, with a lower degree of hospitalizations (0.06%) and an extremely low mortality. Conclusions: this extensive narrative review regarding a vast number of articles highlighted the valuable protection induced by the natural immunity after COVID-19, which seems comparable or superior to the one induced by anti-SARS-CoV-2 vaccination. Consequently, vaccination of the unvaccinated COVID-19-recovered subjects may not be indicated. Further research is needed in order to: (a) measure the durability of immunity over time; (b) evaluate both the impacts of Omicron BA.5 on vaccinated and healed subjects and the role of hybrid immunity.
Complications in Spinal Fusion Surgery: A Systematic Review of Clinically Used Cages
Authors: Veronesi Francesca , Sartori Maria , Griffoni Cristiana , Valacco Marcelo , Tedesco Giuseppe , Davassi Paolo Francesco , Gasbarrini Alessandro , Fini Milena , Barbanti Brodano Giovanni
Published: October 2022

Spinal fusion (SF) comprises surgical procedures for several pathologies that affect different spinal levels, and different cages are employed in SF surgery. Few clinical studies highlight the role of cages in complications beyond the outcomes. The aim of this systematic review is to collect the last 10 years’ worth of clinical studies that include cages in SF surgery, focusing on complications. Three databases are employed, and 21 clinical studies are included. The most-performed SF procedure was anterior cervical discectomy and fusion (ACDF), followed by lumbar SF. The polyetheretherketone (PEEK) cage was the most-used, and it was usually associated with autograft or calcium phosphate ceramics (hydroxyapatite (HA) and tricalcium phosphate (βTCP)). For lumbar SF procedures, the highest percentages of subsidence and pseudoarthrosis were observed with PEEK filled with bone morphogenetic protein 2 (BMP2) and βTCP. For ACDF procedures, PEEK filled with autograft showed the highest percentages of subsidence and pseudoarthrosis. Most studies highlighted the role of surgical techniques in patient complications. There are many interacting events that contextually affect the rate of clinical success or failure. Therefore, in future clinical studies, attention should focus on cages to improve knowledge of chemical, biological and topographical characteristics to improve bone growth and to counteract complications such as cage loosening or breaking and infections.
Radiomics in PI-RADS 3 Multiparametric MRI for Prostate Cancer Identification: Literature Models Re-Implementation and Proposal of a Clinical–Radiological Model
Authors: Corsi Andrea , De Bernardi Elisabetta , Bonaffini Pietro Andrea , Franco Paolo Niccolò , Nicoletta Dario , Simonini Roberto , Ippolito Davide , Perugini Giovanna , Occhipinti Mariaelena , Da Pozzo Luigi Filippo , Roscigno Marco , Sironi Sandro
Published: October 2022

PI-RADS 3 prostate lesions clinical management is still debated, with high variability among different centers. Identifying clinically significant tumors among PI-RADS 3 is crucial. Radiomics applied to multiparametric MR (mpMR) seems promising. Nevertheless, reproducibility assessment by external validation is required. We retrospectively included all patients with at least one PI-RADS 3 lesion (PI-RADS v2.1) detected on a 3T prostate MRI scan at our Institution (June 2016–March 2021). An MRI-targeted biopsy was used as ground truth. We assessed reproducible mpMRI radiomic features found in the literature. Then, we proposed a new model combining PSA density and two radiomic features (texture regularity (T2) and size zone heterogeneity (ADC)). All models were trained/assessed through 100-repetitions 5-fold cross-validation. Eighty patients were included (26 with GS ≥ 7). In total, 9/20 T2 features (Hector’s model) and 1 T2 feature (Jin’s model) significantly correlated to biopsy on our dataset. PSA density alone predicted clinically significant tumors (sensitivity: 66%; specificity: 71%). Our model obtained a sensitivity of 80% and a specificity of 76%. Standard-compliant works with detailed methodologies achieve comparable radiomic feature sets. Therefore, efforts to facilitate reproducibility are needed, while complex models and imaging protocols seem not, since our model combining PSA density and two radiomic features from routinely performed sequences appeared to differentiate clinically significant cancers.
Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review
Authors: He Kang , Xu Shanshan , Shen Lijing , Chen Xiaosong , Xia Qiang , Qian Yongbing
Published: October 2022

Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal hyperinflammatory disorder characterized by dysfunctional cytotoxic T and natural killer cells. Liver transplantation is a predisposing factor for HLH. High mortality rates were reported in 40 cases of HLH following liver transplantation in adults and children. Herein, we describe a case of adult HLH triggered by cytomegalovirus (CMV) infection shortly after liver transplantation. The patient was successfully treated with ruxolitinib combined with a modified HLH-2004 treatment strategy. Our case is the first to report the successful use of ruxolitinib with a modified HLH-2004 strategy to treat HLH in a solid organ transplantation recipient.
Effect of Ospemifene on Densitometric and Plasma Bone Metabolism Biomarkers in Postmenopausal Women Reporting Vulvar and Vaginal Atrophy (VVA)
Authors: Maffei Silvia , Guiducci Letizia
Published: October 2022

Menopausal hormone deficiency can exert multiple effects on various organs. Vulvovaginal atrophy (VVA) is among the most widespread and disabling post-menopausal disorder. Hormonal changes can also result in a markedly increased rate of bone mineral density (BMD) loss. Ospemifene (OSP) is an SERM indicated to treat vulvar and vaginal atrophy (VVA) in postmenopausal women. This study evaluates the long-term effects of ospemifene therapy on bone metabolism and bone mineral parameters in postmenopausal women reporting VVA/GSM. Methods: Women reporting VVA symptoms were included. Bone health profile was investigated in 61 subjects treated with OSP (OSPG) (60 mg/day) and compared with a control group (CG) (n = 67) over 12 months. Results: In the CG, BMD and T-score statistically decreased at the femoral neck (FN), total femur (TF), and lumbar spine (L1–L4). In the OSPG, BMD decreased significantly at FN but tended to remain stable at TF and L1–L4. No changes were observed in bone mineral markers after one year in either group, except BAP, which decreased in OSPG. Conclusions: Long-term OSP treatment improves bone mineral markers at TF and LS and slows bone loss at FN compared to the control group. Overall, OSP exerts a protective effect on bone loss in healthy menopausal women with VVA.
Efficacy of Multisensory Technology in Post-Stroke Cognitive Rehabilitation: A Systematic Review
Authors: Parisi Alessandra , Bellinzona Francesca , Di Lernia Daniele , Repetto Claudia , De Gaspari Stefano , Brizzi Giulia , Riva Giuseppe , Tuena Cosimo
Published: October 2022

Post-stroke, in addition to sensorimotor signs and symptoms, could lead to cognitive deficits. Theories of embodiment stress the role of sensorimotor system and multisensory integration in sustaining high-order cognitive domains. Despite conventional post-stroke cognitive rehabilitation being effective, innovative technologies could overcome some limitations of standard interventions and exploit bodily information during cognitive rehabilitation. This systematic review aims to investigate whether ‘multisensory technologies’ compared to usual care treatment can be a viable alternative for cognitive rehabilitation. By applying PRISMA guidelines, we extracted data and assessed the bias of 10 studies that met the required criteria. We found that multisensory technologies were at least comparable to standard treatment but particularly effective for attention, spatial cognition, global cognition, and memory. Multisensory technologies consisted principally of virtual reality alone or combined with a motion tracking system. Multisensory technologies without motion tracking were more effective than standard procedures, whereas those with motion tracking showed balanced results for the two treatments. Limitations of the included studies regarded the population (e.g., no study on acute stroke), assessment (e.g., lack of multimodal/multisensory pre-post evaluation), and methodology (e.g., sample size, blinding bias). Recent advancements in technological development and metaverse open new opportunities to design embodied rehabilitative programs.
Is There a “Gifted Personality”? Initial Evidence for Differences between MENSA and General Population Members in the HEXACO Personality Inventory
Authors: Fries Jonathan , Kovacs Kristof , Zeilinger Elisabeth L. , Pietschnig Jakob
Published: October 2022

Contrary to the common notion that personality and intelligence are unrelated constructs, numerous correlational studies have demonstrated substantial associations between the two domains. Moreover, samples of intellectually gifted individuals have been found to differ from the general population in specific aspects of their personalities. However, most studies so far have relied on the Five-Factor Model of Personality (FFM), while none have investigated this phenomenon using the HEXACO personality framework. We recruited 617 adult members of the international high-IQ society MENSA and compared them to 3 reference samples (combined N = 112,637) regarding their personalities as measured by the HEXACO-60 personality inventory. We found that gifted persons scored higher in Honesty-Humility and Conscientiousness but lower in Emotionality compared to reference samples. Interestingly, gifted individuals scored only slightly higher in Openness to Experience, and no consistent differences emerged for Agreeableness. We demonstrate that some known personality differences between gifted and non-gifted persons translate from the FFM to the HEXACO model, while others do not. Our results indicate that within the HEXACO factor structure differences in sociability are more pronounced, while intellect-related differences are comparatively weak.
Pin Extrusion for Mechanical Joining from Orbital Formed Tailored Blanks with Local Material Pre-Distribution
Authors: Römisch David , Hetzel Andreas , Wituschek Simon , Lechner Michael , Merklein Marion
Published: October 2022

Pin extrusion is a common process to realise pin structures in different geometrical dimensions for a subsequent joining operation. Nevertheless, the process of pin extrusion offers process limits regarding sheet thinning as a consequence of the punch penetration depth into the sheet. Thereby, cracks at the residual sheet thickness can occur during strength tests, resulting in a failure of the complete joint due to severe thinning. Therefore, measures have to be taken into account to reduce the thinning. One possibility is the application of orbital formed tailored blanks with a local material pre-distribution, which allows a higher sheet thickness in the desired area. Within this contribution, the novel approach of a process combination of orbital forming and pin extrusion is investigated. To reveal the potential of a local material pre-distribution, conventional specimens are compared with previously orbital formed components. Relevant parameters such as the residual sheet thickness, the pin height as well as the average hardness values are compared. The results show a significant positive influence of a local material pre-distribution on the residual sheet thickness as well as the resulting pin height. Furthermore, the strain hardening during orbital forming can be seen as an additional advantage. To conclude the results, the process limits of conventional pin extrusion can be expanded significantly by the application of specimens with a local material pre-distribution.
Automating the Acoustic Detection and Characterization of Sea Ice and Surface Waves
Authors: Sandy Savannah J. , Danielson Seth L. , Mahoney Andrew R.
Published: October 2022

Monitoring the status of Arctic marine ecosystems is aided by multi-sensor oceanographic moorings that autonomously collect data year-round. In the northeast Chukchi Sea, an ASL Environmental Sciences Acoustic Zooplankton Fish Profiler (AZFP) collected data from the upper 30 m of the water column every 10–20 s from 2014 to 2020. We here describe the processing of the AZFP’s 455 kHz acoustic backscatter return signal for the purpose of developing methods to assist in characterizing local sea ice conditions. By applying a self-organizing map (SOM) machine learning algorithm to 15-min ensembles of these data, we are able to accurately differentiate between the presence of open water and sea ice, and thereby characterize statistical properties surface wave height envelopes and ice draft. The ability to algorithmically identify small-scale features within the information-dense acoustic dataset enables efficient and rich characterizations of environmental conditions, such as frequency of sparse ice floes in otherwise open water and brief open-water leads amidst the ice pack. Corrections for instrument tilt, speed of sound, and water level allow us to resolve the sea surface reflection interface to within approximately 0.06 ± 0.09 m. By automating the acoustic data processing and alleviating labor- and time-intensive analyses, we extract additional information from the AZFP backscatter data, which is otherwise used for assessing fish and zooplankton densities and behaviors. Beyond applications to new datasets, the approach opens possibilities for the efficient extraction of new information from existing upward-looking sonar records that have been collected in recent decades.
Surgical Margins in Soft Tissue Sarcoma Management and Corresponding Local and Systemic Recurrence Rates: A Retrospective Study Covering 11 Years and 169 Patients in a Single Institution
Authors: Wittenberg Silvan , Paraskevaidis Melissa , Jarosch Armin , Flörcken Anne , Brandes Franziska , Striefler Jana , Kaul David , Roohani Siyer , Khakzad Thilo , Märdian Sven , Rau Daniel
Published: October 2022

Soft tissue sarcomas (STSs) are a diverse group of rare malignant soft tissue tumors with a high disease burden. Treatment protocols are complex and, to this day, a precise recommendation for the surgical margin width is lacking. The present study aims to analyze the width of the surgical margins in STS resection specimens and analyze them for local and systemic disease-free survival as well as for most frequent histologic STS subtypes. A total of 169 consecutive patients diagnosed and treated in curative intent in our institution following a primary and localized STS of the extremities or trunk from January 2010 to December 2020 were included in this study regardless of age. Our data reveal that low-grade STSs are best controlled locally by a surgical margin ≥2 mm and in this way also preventing distant metastases effectively. Local recurrence-free survival and metastasis-free survival in high-grade STS were improved by intact muscle fascia or periosteum at the margin when compared only to soft tissue. However, the outcome was independent of the surgical margin width, suggesting a close but negative margin may be safe in high-grade STS subtypes with less invasive growth patterns when combined with adjunct radiochemotherapy.
Trauma and Remembering: From Neuronal Circuits to Molecules
Authors: Kéri Szabolcs
Published: October 2022

Individuals with posttraumatic stress disorder (PTSD) experience intrusions of vivid traumatic memories, heightened arousal, and display avoidance behavior. Disorders in identity, emotion regulation, and interpersonal relationships are also common. The cornerstone of PTSD is altered learning, memory, and remembering, regulated by a complex neuronal and molecular network. We propose that the essential feature of successful treatment is the modification of engrams in their unstable state during retrieval. During psychedelic psychotherapy, engrams may show a pronounced instability, which enhances modification. In this narrative review, we outline the clinical characteristics of PTSD, its multifaceted neuroanatomy, and the molecular pathways that regulate memory destabilization and reconsolidation. We propose that psychedelics, acting by serotonin-glutamate interactions, destabilize trauma-related engrams and open the door to change them during psychotherapy.
Computer Aided COVID-19 Diagnosis in Pandemic Era Using CNN in Chest X-ray Images
Authors: Alqahtani Ali , Zahoor Mirza Mumtaz , Nasrullah Rimsha , Fareed Aqil , Cheema Ahmad Afzaal , Shahrose Abdullah , Irfan Muhammad , Alqhatani Abdulmajeed , Alsulami Abdulaziz A. , Zaffar Maryam , Rahman Saifur
Published: October 2022

Early detection of abnormalities in chest X-rays is essential for COVID-19 diagnosis and analysis. It can be effective for controlling pandemic spread by contact tracing, as well as for effective treatment of COVID-19 infection. In the proposed work, we presented a deep hybrid learning-based framework for the detection of COVID-19 using chest X-ray images. We developed a novel computationally light and optimized deep Convolutional Neural Networks (CNNs) based framework for chest X-ray analysis. We proposed a new COV-Net to learn COVID-specific patterns from chest X-rays and employed several machine learning classifiers to enhance the discrimination power of the presented framework. Systematic exploitation of max-pooling operations facilitates the proposed COV-Net in learning the boundaries of infected patterns in chest X-rays and helps for multi-class classification of two diverse infection types along with normal images. The proposed framework has been evaluated on a publicly available benchmark dataset containing X-ray images of coronavirus-infected, pneumonia-infected, and normal patients. The empirical performance of the proposed method with developed COV-Net and support vector machine is compared with the state-of-the-art deep models which show that the proposed deep hybrid learning-based method achieves 96.69% recall, 96.72% precision, 96.73% accuracy, and 96.71% F-score. For multi-class classification and binary classification of COVID-19 and pneumonia, the proposed model achieved 99.21% recall, 99.22% precision, 99.21% F-score, and 99.23% accuracy.
Research on the Improving Performance of Foam Concrete Applied to the Filling of Natural Gas Pipeline Cross-River Tunnel
Authors: Ma Xiaosong , Li Chunbao , Chen Haiyang , Wei Yongqi , Weng Yongmei , Li Shen , Hojiboev Dalerjon
Published: October 2022

The shield tunnel is a common solution for natural gas pipelines crossing rivers. Consequently, the development of natural gas tunnel filling materials with excellent performance is crucial to the safe operation and maintenance of pipelines. The foam concrete offers a reasonable solution. Nevertheless, since its inherent compressive strength decreases almost proportionally with the decrease in density, obstacles remain concerning obtaining the high density and relatively low strength required for natural gas tunnel filling. Here, a synergistic optimization strategy was proposed involving the orthogonal test, univariate control, and comprehensive balance method. It involves modifying the type and proportion of cementitious matrix, in particular by incorporating fly ash and PVA fibers in the mix design, and synergetic determining the best mix ratio from the aspects of compressive strength, stability, and dry density. The obtained foam concrete has a compressive strength of 4.29 MPa (FC4) and a dry density of 1060.59 kg/m3 (A11), which meets the requirements of pipeline pressure and pipeline anti-floating. This study is applied to the Yangtze River shield crossing project of the Sino-Russian Eastern Gas Pipeline, and ANSYS was used to simulate the stress and deformation of the foam concrete. This work provides an efficient foam concrete optimization mix scheme, and supports the application of foam concrete in the filling of the long-distance cross-river natural gas tunnels.
In-Depth Characterization of Laser-Welded Aluminum-and-Copper Dissimilar Joint for Electric Vehicle Battery Connections
Authors: Ali Sajid , Shin Joonghan
Published: October 2022

With advancements in the automotive industry, the demand for electric vehicles (EVs) has remarkably increased in recent years. However, the EV battery, which is a vital part of the EV, poses certain challenges that limit the performance of the EVs. The joining of dissimilar materials for different components affects the electrical and mechanical performances of EV batteries. Laser beam welding is a promising technique for joining Al and Cu for application in secondary battery fabrication because of the precise control over heat input and high process speed. However, the production of Al–Cu joints remains challenging because of the differences between their thermal and metallurgical properties and the resulting formation of brittle and hard intermetallic compounds, which reduce mechanical and electric properties. Thus, it is vital to characterize the weld to improve joint performance and enhance the laser welding process. This study investigates the joining of an Al alloy (AA1050) with Ni-coated Cu using a continuous-wave Yb fiber laser. The evaluation of the weld morphology showed a correlation between the weld characteristics and process parameters (laser power and welding speed). The weld interface width and penetration depth into the lower sheet (Cu) both increased with increasing heat input. Optical microscopy of the weld cross-section revealed many defects, such as voids and cracks. Scanning electron microscopy (SEM) with energy-dispersive X-ray spectroscopy (EDS) was employed to examine the weld microstructure. The composition analysis revealed the presence of mixed morphology of Al–Cu eutectic alloy (α-Al+Θ-Al2Cu) phase in the form of dendrites in the weld fusion zone with traces of the highly brittle Al4Cu9 phase at a high heat input condition. Furthermore, the electrical contact resistance of the weld seam was measured to determine the correlation between heat input and resistance. In addition, Vickers microhardness measurements were performed on the weld cross-section to validate the SEM/EDS results.
Fabrication and Characterization of Au-Decorated MCM-41 Mesoporous Spheres Using Laser-Ablation Technique
Authors: Al Qahtani Hassan S. , Akhtar Sultan , Alam Mir Waqas , Hossain Mohammad Kamal , Al Baroot Abbad , Alheshibri Muidh
Published: October 2022

This study reports the synthesis of Au-decorated MCM-41 mesoporous nanoparticles using a laser-ablation technique. It was observed that the number of Au attached to MCM-41 nanostructures was dependent on the amount of encapsulated Cationic surfactant (cetyl ammonium bromide (CTAB) volume. The chemical group of the prepared nanoparticles was analyzed by FT-IR spectroscopy, where different absorption peaks corresponding to Au and MCM-41 were observed. The observed band region was ∼1090, 966, 801, 2918, and 1847 cm−1 for different samples, clearly confirming the successful preparation of MCM-41 with CTAB and Au-decorated MCM-41 nanoparticles using environmentally friendly laser-ablation approach. The surface morphology of the prepared nanoparticles were performed using TEM techniques. The TEM analysis of the MCM-41 specimen showed silica spheres with an average size of around 200 nm. Furthermore, Raman spectroscopy was done to evaluate the chemical structure of the prepared nanoparticles. It was seen that the prepared Au NPs decorated the MCM-41 system facilitated strong Raman peaks of CTAB. In addition, eight distinct Raman peaks were observed in the presence of Au NPs. This new functionalized method using the laser-ablation approach for mesoporous nanoparticles will participate effectively in multiple applications, especially the encapsulated molecule sensing and detection.
Utilization of Lead Slag as In Situ Iron Source for Arsenic Removal by Forming Iron Arsenate
Authors: Chen Pan , Zhao Yuxin , Yao Jun , Zhu Jianyu , Cao Jian
Published: October 2022

In situ treatment of acidic arsenic-containing wastewater from the non-ferrous metal smelting industry has been a great challenge for cleaner production in smelters. Scorodite and iron arsenate have been proved to be good arsenic-fixing minerals; thus, we used lead slag as an iron source to remove arsenic from wastewater by forming iron arsenate and scorodite. As the main contaminant in wastewater, As(III) was oxidized to As(V) by H2O2, which was further mineralized to low-crystalline iron arsenate by Fe(III) and Fe(II) released by lead slag (in situ generated). The calcium ions released from the dissolved lead slag combined with sulfate to form well-crystallized gypsum, which co-precipitated with iron arsenate and provided attachment sites for iron arsenate. In addition, a silicate colloid was generated from dissolved silicate minerals wrapped around the As-bearing precipitate particles, which reduced the arsenic-leaching toxicity. A 99.95% removal efficiency of arsenic with initial concentration of 6500 mg/L was reached when the solid–liquid ratio was 1:10 and after 12 h of reaction at room temperature. Moreover, the leaching toxicity of As-bearing precipitate was 3.36 mg/L (As) and 2.93 mg/L (Pb), lower than the leaching threshold (5 mg/L). This work can promote the joint treatment of slag and wastewater in smelters, which is conducive to the long-term development of resource utilization and clean production.
Study of Temperature on the Corrosion Behavior of Antibacterial Steel by a Large−Scale Multiphase Flow Corrosion Test Loop
Authors: Zhang Yunan , Zhang Yongqiang , Wen Lei , Kong Wei , Yang Yinghua , Zhu Jinyang , Liu Fuhai , Jin Ying
Published: October 2022

The System #2 flow loop used in this study is a 4−inch−diameter, high−temperature, high−pressure system. In situ corrosion and electrochemical measurements were performed using a homemade flat corrosion specimen and a three−electrode probe. The experiment results show that temperature has an accelerated influence on the corrosion of antibacterial alloy steel. With the increase of temperature and the presence of O2 in the environment, a loose and porous corrosion product film was formed on the surface of the resistant steel, which made it easier for the corrosion medium to enter the corrosion product film from the pore, thus accelerating the corrosion.
Fatigue Evaluation for Innovative Excavator Arms Made of Composite Material
Authors: Solazzi Luigi , Buffoli Andrea , Ceresoli Federico
Published: October 2022

This research reports the results related to the evaluation of the fatigue phenomenon of the arms of a medium–large excavator made of composite material (carbon fiber) instead of the classic constructional steel S355 (UNI EN 10025-3). In the numerical sizing phase, it was obtained that the overall weight of the excavator’s arms made of composite material is about 35% of the same components made of steel, obviously with equal performance in terms of the safety static coefficient, rigidity, and critical buckling load. The evaluation of the fatigue behaviour (assuming 5.25 × 106 load cycles) applied for each load condition analyzed (levelling from the maximum distance to the minimum, lifting at the maximum distance, lifting at the minimum distance and rotation) shows the magnitude of the safety coefficients both related to the allowable stress and relative to the number of cycles acceptable. The assumption instead of combined cycles (involving one or more load conditions) leads to a significant reduction in the magnitude of the safety coefficients. The implementation of a loading cycle plan resulting from the different load conditions must be reliably assessed to evaluate as accurately as possible the fatigue behavior of the excavator arms made of composite material.
Painting Materials and Technique for the Expression of Chinese Inheritance in Liu Kang’s Huangshan and Guilin Landscapes (1977–1996)
Authors: Lizun Damian , Kurkiewicz Teresa , Szczupak Bogusław , Rogóż Jarosław
Published: October 2022

Liu Kang (1911–2004) was a Chinese artist who settled in Singapore in 1945 and eventually became a leading modern artist in Singapore. He received academic training in Shanghai (1926–1928) and Paris (1929–1932). Liu Kang’s frequent visits to China from the 1970s to the 1990s contributed to a special artistic subject—the Huangshan and Guilin mountains. This subject matter triggered an uncommon painting approach for his oeuvre. In this context, this study elucidates the artist’s choice of materials and methods for the execution of 11 paintings, dating between 1977 and 1996, depicting Huangshan and Guilin landscapes. The paintings belong to the collection of the National Gallery Singapore. They were investigated with a combination of non- and micro-invasive techniques, supplemented by a wealth of documentary sources and art history research. The obtained results highlight the predominant use of hardboards resembling Masonite® Presdwood® without the application of an intermediate ground layer. Commercially prepared cotton and linen painting supports were used less frequently, and their structure and ground composition were variable. This study revealed the use of a conventional colour base for the execution of the paintings—a consistent colour scheme favouring ultramarine, yellow and red iron-containing earths, viridian and titanium white. Less commonly used pigments include Prussian blue, cobalt blue, phthalocyanine blue, phthalocyanine green, naphthol red AS-D, umber, Cr-containing yellow(s), cadmium yellow or its variant(s), Hansa yellow G, lithopone and/or barium white and zinc white and bone black. The documentary sources indirectly pointed to the use of Royal Talens, Rowney and Winsor & Newton, brands of oil paints. Moreover, technical and archival findings indicated the artist’s tendency to recycle rejected compositions, thereby strongly suggesting that the paintings were executed in the studio. Although this study focuses on the Singapore artist and his series of paintings relating to China, it contributes to existing international studies of modern artists’ materials.
Comparative Study on the Crystallography of Isothermal and Athermal Precipitations in HCP–BCC System
Authors: Liu Hongwei
Published: October 2022

Due to the diversity of the lattice parameter ratio c/a of hexagonal structure and precipitation mechanism, a systematic overview of this transformation has not been fully established, which draws back the attempt to control crystallographic features of the precipitates and microstructures of applied metals and alloys. Here, a comparative investigation to the crystallography of isothermal and athermal precipitations occurring in the HCP–BCC system was demonstrated in a full range of the lattice parameter ratio by using an invariant deformation element (IDE) model. It was then proposed that a precipitation in the HCP–BCC system could be either of the isothermal type if the observed habit plane Miller index falls into a zone axis of BCC <11w>(w ≠ 0) or HCP 211¯0, or the athermal type when it is found to locate in a zone axis of BCC <11w](w = 0) or HCP [0001]. The crystallographic investigation on the precipitations in the HCP–BCC system in a full range of the lattice parameter may be a practical guide for computing material science when building a crystallographic interface model under an optimised orientation relationship, which is necessary to minimise the transformation system energy.