bluuebunny/crossref_metadata_2025 huggingface dataset:
CORRELATION ESTIMATION IN HYBRID SYSTEMS
Authors: Law Baron
Published: May 2023

A simple method is proposed to estimate the instantaneous correlations between state variables in a hybrid system from the empirical correlations between observable market quantities such as spot rates, stock prices and implied volatilities. The new algorithm is extremely fast since only low-dimension linear systems are involved. If the resulting matrix from the linear systems is not positive semidefinite, the shrinking method, which requires only bisection-style iterations, is recommended to convert the matrix to positive semidefinite. The square of short-term at-the-money implied volatility is suggested as the proxy for the unobservable stochastic variance. When the implied volatility is not available, a simple trick is provided to fill in the missing correlations. Numerical study shows that the estimates are reasonably accurate, when using more than 1000 data points. In addition, the algorithm is robust to misspecified interest rate model parameters and the short-sampling-period assumption. G2[Formula: see text] and Heston are used for illustration, but the method can be extended to affine term-structure, local volatility and jump-diffusion models, with or without stochastic interest rate.
High-Frequency Resonances of Train-Track Coupled System Due to Multiple Wheels Interference
Authors: Ge Yaojun , Lei Simian , Li Qi
Published: May 2023

A significant resonance pattern at high frequencies around 400[Formula: see text]Hz to 1000[Formula: see text]Hz has been well observed from measured rail accelerations. Such resonances are key issues for rail noise and corrugation. Although this pattern has been noted and discussed in various papers in terms of wave reflections among multiple wheels, the aim of this study is to develop novel dynamic model and reveal generation mechanism of this resonance phenomenon with the train-track coupled system. An infinite Timoshenko beam with continuous supports is adopted for modeling the track system, and the point and transfer receptances of the rail for a moving excitation are explicitly deduced by the residue theorem together with a Fourier transform-based method. A frequency-domain method is then established to calculate the power spectral densities (PSD) of the train-track coupled system responses to stochastic irregularities with the moving vehicle model with multiple wheels. It is found that the high-frequency resonances occur when the reflected waves generated from multiple wheels on the rail are exactly in phase with the initial track irregularity. The load speed has negligible influence on the wheel–rail interaction in the lower frequency range and a small influence in the upper frequency range only for very high train speeds.
Dynamic Reliability Analysis of Running Safety and Stability of a High-Speed Maglev Train on a Guideway Bridge
Authors: Wang Lidong , Bu Xiumeng , Hu Peng , Han Yan , Cai Chunsheng
Published: May 2023

The dynamic performance of high-speed maglev trains, a next-generation rapid transit system, has received continuous attention in recent years. In this study, a dynamic reliability analysis method for a high-speed maglev train–guideway coupled system was proposed. First, a refined model of the maglev vehicle–bridge interaction system was established, where the vehicle subsystem was simulated as a rigid body-spring-damper model with 101 degrees of freedom. The guideway subsystem was simulated as a finite element model, and these two subsystems were coupled as an entire system through a magnet–rail interaction model with a proportional-derivative (PD) controller. Second, a dimension-reduction method for the simulation of representative samples of track irregularities was developed, and thus the number of random variables in the system was reduced to four. Finally, an efficient method for the calculation of the dynamic reliability of a maglev train–guideway coupled system was proposed using the probability density evolution method-based equivalent extreme value principle. With numerical examples, the accuracy of the maglev train–guideway interaction model was verified by comparing it with field measurement data from the Shanghai high-speed maglev line. The accuracy of the proposed dynamic reliability analysis method was confirmed by comparing three types of results, that is, the mean value time-history curve, the probability density function, and the cumulative distribution function of extreme values, obtained by the Monte Carlo method. Finally, the dynamic reliability of the running safety and stability of the maglev vehicle at a speed of 430 km/h and the variation laws of the dynamic reliabilities with train speed were examined in detail.
A class of non-weight modules over the super-BMS3 algebra
Authors: Chen Haibo , Dai Xiansheng , Liu Ying , Su Yucai
Published: May 2023

In the present paper, non-weight modules over the super-BMS3 algebras [Formula: see text] ([Formula: see text] or [Formula: see text]) are constructed. Assume that [Formula: see text] and [Formula: see text] are the Cartan subalgebra (modulo center) of [Formula: see text] and [Formula: see text], respectively. These modules over [Formula: see text] when restricted to the [Formula: see text] are free of rank [Formula: see text], while these modules over [Formula: see text] when restricted to the [Formula: see text] are free of rank [Formula: see text]. Then we determine the necessary and sufficient conditions for these modules being simple, as well as determining the necessary and sufficient conditions for two [Formula: see text]-modules being isomorphic.
Deep learning and geometric deep learning: An introduction for mathematicians and physicists
Authors: Fioresi R. , Zanchetta F.
Published: May 2023

In this expository paper, we want to give a brief introduction, with few key references for further reading, to the inner functioning of the new and successful algorithms of Deep Learning and Geometric Deep Learning with a focus on Graph Neural Networks. We go over the key ingredients for these algorithms: the score and loss function and we explain the main steps for the training of a model. We do not aim to give a complete and exhaustive treatment, but we isolate few concepts to give a fast introduction to the subject. We provide some appendices to complement our treatment discussing Kullback–Leibler divergence, regression, Multi-layer Perceptrons and the Universal Approximation theorem.
Evolving Software: Combining Online Learning with Mutation-Based Stochastic Search
Authors: Renzullo Joseph , Weimer Westley , Forrest Stephanie
Published: May 2023

Evolutionary algorithms and related mutation-based methods have been used in software engineering, with recent emphasis on the problem of repairing bugs. In this work, programs are typically not synthesized from a random start. Instead, existing solutions—which may be flawed or inefficient—are taken as starting points, with the evolutionary process searching for useful improvements. This approach, however, introduces a challenge for the search algorithm: what is the optimal number of neutral mutations that should be combined? Too much is likely to introduce errors and break the program while too little hampers the search process, inducing the classic tradeoff between exploration and exploitation.

In the context of software improvement, this work considers MWRepair, an algorithm for enhancing mutation-based searches, which uses online learning to optimize the tradeoff between exploration and exploitation. The aggressiveness parameter governs how many individual mutations should be applied simultaneously to an individual between fitness evaluations. MWRepair is evaluated in the context of automated program repair problems, where the goal is repairing software bugs with minimal human involvement. The article analyzes the search space for automated program repair induced by neutral mutations, finding that the greatest probability of finding successful repairs often occurs when many neutral mutations are applied to the original program. Moreover, repair probability follows a characteristic, unimodal distribution. MWRepair uses online learning to leverage this property, finding both rare and multi-edit repairs to defects in the popular Defects4J benchmark set of buggy Java programs.
Isothermal Microcalorimetric Analysis of Li/CFx Battery Discharge
Authors: Arnot David J. , Takeuchi Esther S. , Marschilok Amy C. , Takeuchi Kenneth J.
Published: May 2023

Lithium/carbon monofluoride (Li/CFx) batteries generate substantial amounts of heat during discharge in part due to the large deviation of the loaded voltage from the measured and thermodynamically predicted open circuit voltage. Here, we further analyze this system by estimating the equilibrium voltage (

V

e
q

) and its temperature dependence

(
d

V

e
q

/
d
T
)

over the entire discharge range. Based on these results, the ohmic and entropic heat contributions to the overall heat flow are calculated from experimental data. The ohmic heat flow is consistent with an electrochemical impedance spectroscopy model and electrode density measurements, indicating decreasing porosity of the electrode during discharge. Entropic heating increases during discharge as the cell reaction becomes increasingly entropically unfavorable. The total energy dissipated by the cell (electrical and thermal) remains similar over the entire discharge, evidence for a two-phase reaction with a constant, and rate-independent,

Δ

G

r
x
n

of about −465 kJ mol−1. However, near the end of discharge (>90% DOD),

Δ

G

r
x
n

changes significantly indicating possible secondary reactions.
In Situ Measurement of Dynamic Internal Short Circuit Resistance during Nail Penetration of Lithium-Ion Cells and its Implications on Cell Robustness and Abuse Tolerance
Authors: Liu Siyi , Huang Shan , Zhou Qian , Snyder Kent , Long Mary K. , Zhang Guangsheng
Published: May 2023

Here we report a method for in situ measurement of internal short circuit (ISC) resistance during nail penetration testing of lithium-ion cells. The method is demonstrated with dry cells, wet dummy cells, and working cells using a small nail and slow penetration speed. ISC current and ISC temperature are also measured during the tests. It is confirmed that the ISC resistance changes dramatically, by several orders of magnitude, during nail penetration. More importantly, it is found that the stable resistance after full penetration is much higher than the lowest dynamic resistance at earlier stages of nail penetration. Analysis based on such a stable ISC resistance would underestimate the risk of thermal runaway during nail penetration tests. It is also found that ISC in some cases may be mitigated due to melting or rupture of aluminum foil surrounding the nail, implying a mechanism that may be able to be used towards the design of more robust/abuse tolerant Li-ion cells. Lastly, it is found that nail penetration using a larger nail reduces ISC resistance during penetration of cells but the general behaviors of ISC resistance are similar to those during smaller nail penetration.
Electrochemical Stability Window and Electrolyte Breakdown Mechanisms of Lithium Lanthanum Titanate
Authors: Ring Joseph , Laa Lisa , Limbeck Andreas , Vonk Vedran , Volkov Sergey , Nenning Andreas , Fleig Jürgen
Published: May 2023

Perovskite-type La0.57Li0.29TiO3 (LLTO) is a promising solid electrolyte material with high Li-ion conductivity. However, its experimental electrochemical stability window is not precisely known, and thus the compatibility with potential electrode materials is partly unclear. In this contribution, we present results from electrochemical and analytical experiments to elucidate the stability of LLTO when being polarized with Li-ion-blocking Pt electrodes. Above 2.5 V, a darkened color front starts moving from the cathode to the anode, leading to electrolyte degradation. While first-principles calculations predict the appearance of new phases as decomposition products, we find zones with modified defect chemical properties originating from the anode and cathode. The darkened zone forming at the cathode contains Ti3+ polarons with high mobility, which leads to a mixed ion-electron conductivity, already for a very small Li excess concentration. Next to the anode a spatially very confined, weakly conductive Li depletion zone forms. The spatially confined but substantial Li depletion near the anode could be quantified by analytical laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). In contrast to first-principles calculations, no new phases were found near the anode, according to synchrotron-based grazing incidence XRD measurements.
HER2 Negative Mammary Paget’s Disease or In Situ Melanoma? A Case Report and Review of the Literature
Authors: Boșoteanu Luana-Andreea , Așchie Mariana , Orǎșanu Cristian Ionuţ , Boșoteanu Mădălina
Published: May 2023

Mammary Paget’s disease (MPD) is a rare histological condition, accounting for 1-4% of female breast cancers, which may appear either independently (1.4-13% of the cases), or in association with an in situ or invasive ductal carcinoma (approximately 90% of the cases). The purpose of this article is to highlight the histopathological challenges related to the microscopical polymorphism of this disease and the utmost importance of immunohistochemistry in the thorough process of Paget’s disease differential diagnosis. Moreover, the primary objective of this review of literature was to corroborate the existing data concerning the potential peculiar immunohistochemical profile that mammary Paget’s disease might express. We report the case of a 44-year-old female patient, histopathologically diagnosed with HER2-negative MPD accompanying an invasive mammary carcinoma. The histopathological and immunohistochemical approach is derived from the exigency of excluding the possibility of synchronous tumors—a mammary invasive carcinoma, accompanied by another component with MPD phenotypic mimicry. The unexpected negative HER2 reaction is conducted to a primary focus on excluding a malignant melanoma in situ. The absence of MelanA and S100 immunoexpression and lack of pigmentation and clinical aspects infirmed it. Bowen’s disease was invalidated by its rare presentation in the breast cutaneous tissue and the absence of individual risk factors suggestive of an existing immunosuppressive status. In the case of similar morphoimmunohistochemical aspects, significant expression of Ki-67 signals MPD, an immunoreactivity that helped distinguish the cellular population from Toker cells. The great similarity of MPD with other benign and malignant cutaneous tumors might determine delay or misdiagnosis. Thus, the utmost importance of immunohistochemistry is reflected in its prognostic significance and geared towards extending the therapeutic arsenal.
Effect of Raphia vinifera Fibre Size and Reinforcement Ratio on the Physical and Mechanical Properties of an Epoxy Matrix Composite: Micromechanical Modelling and Weibull Analysis
Authors: Youbi Syrille Brice Tchinwoussi , Harzallah Omar , Tagne Nicodème Rodrigue Sikame , Huisken Paul William Mejouyo , Stanislas Tido Tiwa , Drean Jean-Yves , Bistac Sophie , Njeugna Ebenezer
Published: May 2023

This study evaluates the effects of lengths and reinforcement ratio of Raphia vinifera fibres (RVFs) on the physical and mechanical properties of an epoxy matrix composite. Three volume fractions (20%, 30%, and 40%) and three lengths (5, 10, and 15 mm) of fibres were used to produce the composite, and the samples were subjected to the absolute and apparent density, porosity, water absorption rate, and tensile and flexural strength. The probability of failure of the composite is described by the means of two-factor Weibull model. In addition, a theoretical approach to predict mechanical characteristics based on empirical models was carried out. The results show that the addition of RVF decreases the density of the composite, while the porosity and absorption rate increase. The mechanical test shows that the tensile and flexural stress and Young’s modulus of the composite are lowered compared to those of the resin alone. Multivariate analysis of variance (MANOVA) and Tukey test showed that fibre lengths and reinforcement ratio significantly lower the mechanical properties of the composite. The distribution of strength and Young’s modulus follows Weibull’s law. Furthermore, the Cox–Krenkel mathematical model has the best approximated model for the experimental results after the tensile test. Based on these results, this material could be used as reinforcement parts for vehicle backrests or interior decoration in the construction industry.
Acquisition of Key Vacuum-Assisted Resin Transfer Molding Parameters through Reverse Scanning for Application in the Manufacturing of Large Fiber-Reinforced-Plastic Products
Authors: Luo Guang-Min , Chen Kai-Lin , Hsu Chen-Ting
Published: May 2023

Software-based mold flow analysis is often performed to confirm optimized resin pipe arrangements. In this study, the GeoDict software and reverse scanning were employed to develop a method for performing rapid porosity and permeability estimation. A comparison of the results from one-dimensional resin flow and Easyperm tests revealed a 10% variation in the porosity and permeability parameters obtained through the proposed rapid estimation method. In addition, the obtained parameters were substituted into a Moldex3D model to simulate the resin flow on the personal watercraft hull during vacuum-assisted resin transfer molding (VARTM). A comparison of simulation results and hull infusion results revealed that the integration of the proposed rapid estimation method with Moldex3D allowed for the accurate simulation of the resin flow in large fiber-reinforced-plastic (FRP) products (variation <8%). The proposed method can be applied to large wind turbine FRP parts and large FRP yacht components to increase process planning efficiency and product stability.
PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING–Type I Interferon Signaling in Glioblastoma
Authors: Mondal Isha , Das Oishika , Sun Raymond , Gao Jian , Yu Bohyeon , Diaz Aaron , Behnan Jinan , Dubey Abhishek , Meng Zhipeng , Eskandar Emad , Xu Beisi , Lu Rongze Olivia , Ho Winson S.
Published: May 2023

Glioblastoma (GBM) is an immunologically “cold” tumor that does not respond to current immunotherapy. Here, we demonstrate a fundamental role for the α-isoform of the catalytic subunit of protein phosphatase-2A (PP2Ac) in regulating glioma immunogenicity. Genetic ablation of PP2Ac in glioma cells enhanced double-stranded DNA (dsDNA) production and cGAS–type I IFN signaling, MHC-I expression, and tumor mutational burden. In coculture experiments, PP2Ac deficiency in glioma cells promoted dendritic cell (DC) cross-presentation and clonal expansion of CD8+ T cells. In vivo, PP2Ac depletion sensitized tumors to immune-checkpoint blockade and radiotherapy treatment. Single-cell analysis demonstrated that PP2Ac deficiency increased CD8+ T-cell, natural killer cell, and DC accumulation and reduced immunosuppressive tumor-associated macrophages. Furthermore, loss of PP2Ac increased IFN signaling in myeloid and tumor cells and reduced expression of a tumor gene signature associated with worse patient survival in The Cancer Genome Atlas. Collectively, this study establishes a novel role for PP2Ac in inhibiting dsDNA–cGAS–STING signaling to suppress antitumor immunity in glioma.

Significance:

PP2Ac deficiency promotes cGAS–STING signaling in glioma to induce a tumor-suppressive immune microenvironment, highlighting PP2Ac as a potential therapeutic target to enhance tumor immunogenicity and improve response to immunotherapy.
Supplementary Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
Authors: Himbert Caroline , Warby Christy A. , Gigic Biljana , Ose Jennifer , Lin Tengda , Viskochil Richard , Peoples Anita R. , Ashworth Anjelica , Schrotz-King Petra , Scaife Courtney L. , Cohan Jessica N. , Jedrzkiewicz Jolanta , Schirmacher Peter , Grady William M. , Cohen Stacey A. , Krane Mukta , Figueiredo Jane C. , Toriola Adetunji T. , Siegel Erin M. , Shibata David , Round June L. , Huang Lyen C. , Li Christopher I. , Schneider Martin , Ulrich Alexis , Hardikar Sheetal , Ulrich Cornelia M.
Published: May 2023

Supplementary Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
Supplementary Figure from Recalibrating Risk Prediction Models by Synthesizing Data Sources: Adapting the Lung Cancer PLCO Model for Taiwan
Authors: Chien Li-Hsin , Chen Tzu-Yu , Chen Chung-Hsing , Chen Kuan-Yu , Hsiao Chin-Fu , Chang Gee-Chen , Tsai Ying-Huang , Su Wu-Chou , Huang Ming-Shyan , Chen Yuh-Min , Chen Chih-Yi , Liang Sheng-Kai , Chen Chung-Yu , Wang Chih-Liang , Hung Hsiao-Han , Jiang Hsin-Fang , Hu Jia-Wei , Rothman Nathaniel , Lan Qing , Liu Tsang-Wu , Chen Chien-Jen , Yang Pan-Chyr , Chang I-Shou , Hsiung Chao A.
Published: May 2023

Supplementary Figure from Recalibrating Risk Prediction Models by Synthesizing Data Sources: Adapting the Lung Cancer PLCO Model for Taiwan
Supplementary Figure from RNA-Based Classification of Homologous Recombination Deficiency in Racially Diverse Patients with Breast Cancer
Authors: Walens Andrea , Van Alsten Sarah C. , Olsson Linnea T. , Smith Markia A. , Lockhart Alex , Gao Xiaohua , Hamilton Alina M. , Kirk Erin L. , Love Michael I. , Gupta Gaorav P. , Perou Charles M. , Vaziri Cyrus , Hoadley Katherine A. , Troester Melissa A.
Published: May 2023

Supplementary Figure from RNA-Based Classification of Homologous Recombination Deficiency in Racially Diverse Patients with Breast Cancer
Supplementary Data from RNA-Based Classification of Homologous Recombination Deficiency in Racially Diverse Patients with Breast Cancer
Authors: Walens Andrea , Van Alsten Sarah C. , Olsson Linnea T. , Smith Markia A. , Lockhart Alex , Gao Xiaohua , Hamilton Alina M. , Kirk Erin L. , Love Michael I. , Gupta Gaorav P. , Perou Charles M. , Vaziri Cyrus , Hoadley Katherine A. , Troester Melissa A.
Published: May 2023

Supplementary Data from RNA-Based Classification of Homologous Recombination Deficiency in Racially Diverse Patients with Breast Cancer
Supplementary Table from A Cross-Sectional Study of the Prevalence of Anal Dysplasia among Women with High-Grade Cervical, Vaginal, and Vulvar Dysplasia or Cancer: The PANDA Study
Authors: Batman Samantha , Messick Craig A. , Milbourne Andrea , Guo Ming , Munsell Mark F. , Fokom-Domgue Joel , Salcedo Mila , Deshmukh Ashish , Dahlstrom Kristina R. , Ogburn Mallory , Price Anthony , Fleming Nicole D. , Taylor Jolyn , Shafer Aaron , Cobb Lauren , Sigel Keith , Sturgis Erich M. , Chiao Elizabeth Y. , Schmeler Kathleen M.
Published: May 2023

Supplementary Table from A Cross-Sectional Study of the Prevalence of Anal Dysplasia among Women with High-Grade Cervical, Vaginal, and Vulvar Dysplasia or Cancer: The PANDA Study
Supplementary Figure from Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk
Authors: Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Skinner Tina L. , Lay Jannelle , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: May 2023

Supplementary Figure from Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk
Supplementary Table 2 from Association Between Metabolic Syndrome and Risk of Esophageal Cancer: a Nationwide Population-Based Study
Authors: Lee Ji Eun , Han Kyungdo , Yoo Juhwan , Yeo Yohwan , Cho In Young , Cho Belong , Park Jin-Ho , Shin Dong Wook , Cho Jong Ho , Park Yong-Moon
Published: May 2023

Baseline characteristics of the non-smoker/ non-drinker group
Supplementary Table from Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium
Authors: Pastorino Roberta , Sassano Michele , Danilo Tiziano Francesco , Giraldi Luca , Amore Rosarita , Arzani Dario , Abiusi Emanuela , Ahrens Wolfgang , Vilches Laia Alemany , Canova Cristina , Healy Claire Mary , Holcatova Ivana , Lagiou Pagona , Polesel Jerry , Popovic Maja , Nygård Ståle , Cadoni Gabriella , Znaor Ariana , Boffetta Paolo , Matsuo Keitaro , Oze Isao , Brennan Paul , Boccia Stefania
Published: May 2023

Supplementary Table from Plasma miR-151-3p as a Candidate Diagnostic Biomarker for Head and Neck Cancer: A Cross-sectional Study within the INHANCE Consortium
Supplementary Figure from Progress with Metabolomic Blood Tests for Gastrointestinal Cancer Diagnosis—An Assessment of Biomarker Translation
Authors: Savva Katerina-Vanessa , Das Bibek , Antonowicz Stefan , Hanna George B. , Peters Christopher J.
Published: May 2023

Supplementary Figure from Progress with Metabolomic Blood Tests for Gastrointestinal Cancer Diagnosis—An Assessment of Biomarker Translation
Supplementary Table from Associations between Serum 25-Hydroxyvitamin D Levels and Health-Related Quality-of-Life Measures in Patients with Breast Cancer: A Longitudinal Study
Authors: Cross Temara , George Anthony , Attwood Kristopher , Zhang Yali , O'Connor Tracey L. , Barone Nancy , Hulme Karen , Ambrosone Christine B. , Yao Song , Hong Chi-Chen
Published: May 2023

Supplementary Table from Associations between Serum 25-Hydroxyvitamin D Levels and Health-Related Quality-of-Life Measures in Patients with Breast Cancer: A Longitudinal Study
Supplementary Table from Cost-Effectiveness of Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Treated with Procarbazine and/or Infradiaphragmatic Radiotherapy
Authors: Ykema Berbel L.M. , Gini Andrea , Rigter Lisanne S. , Spaander Manon C.W. , Moons Leon M.G. , Bisseling Tanya M. , de Boer Jan Paul , Verbeek Wieke H.M. , Lugtenburg Pieternella J. , Janus Cecile P.M. , Petersen Eefke J. , Roesink Judith M. , van der Maazen Richard W.M. , Aleman Berthe M.P. , Meijer Gerrit A. , van Leeuwen Flora E. , Snaebjornsson Petur , Carvalho Beatriz , van Leerdam Monique E. , Lansdorp-Vogelaar Iris
Published: May 2023

Supplementary Table from Cost-Effectiveness of Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Treated with Procarbazine and/or Infradiaphragmatic Radiotherapy
Data from Recalibrating Risk Prediction Models by Synthesizing Data Sources: Adapting the Lung Cancer PLCO Model for Taiwan
Authors: Chien Li-Hsin , Chen Tzu-Yu , Chen Chung-Hsing , Chen Kuan-Yu , Hsiao Chin-Fu , Chang Gee-Chen , Tsai Ying-Huang , Su Wu-Chou , Huang Ming-Shyan , Chen Yuh-Min , Chen Chih-Yi , Liang Sheng-Kai , Chen Chung-Yu , Wang Chih-Liang , Hung Hsiao-Han , Jiang Hsin-Fang , Hu Jia-Wei , Rothman Nathaniel , Lan Qing , Liu Tsang-Wu , Chen Chien-Jen , Yang Pan-Chyr , Chang I-Shou , Hsiung Chao A.
Published: May 2023

AbstractBackground:
Methods synthesizing multiple data sources without prospective datasets have been proposed for absolute risk model development. This study proposed methods for adapting risk models for another population without prospective cohorts, which would help alleviate the health disparities caused by advances in absolute risk models. To exemplify, we adapted the lung cancer risk model PLCOM2012, well studied in the west, for Taiwan.
Methods:
Using Taiwanese multiple data sources, we formed an age-matched case–control study of ever-smokers (AMCCSE), estimated the number of ever-smoking lung cancer patients in 2011–2016 (NESLP2011), and synthesized a dataset resembling the population of cancer-free ever-smokers in 2010 regarding the PLCOM2012 risk factors (SPES2010). The AMCCSE was used to estimate the overall calibration slope, and the requirement that NESLP2011 equals the estimated total risk of individuals in SPES2010 was used to handle the calibration-in-the-large problem.
Results:
The adapted model PLCOT-1 (PLCOT-2) had an AUC of 0.78 (0.75). They had high performance in calibration and clinical usefulness on subgroups of SPES2010 defined by age and smoking experience. Selecting the same number of individuals for low-dose computed tomography screening using PLCOT-1 (PLCOT-2) would have identified approximately 6% (8%) more lung cancers than the US Preventive Services Task Forces 2021 criteria. Smokers having 40+ pack-years had an average PLCOT-1 (PLCOT-2) risk of 3.8% (2.6%).
Conclusions:
The adapted PLCOT models had high predictive performance.
Impact:
The PLCOT models could be used to design lung cancer screening programs in Taiwan. The methods could be applicable to other cancer models.
Data from Association of Prostate-Specific Antigen Levels with Prostate Cancer Risk in a Multiethnic Population: Stability Over Time and Comparison with Polygenic Risk Score
Authors: Chou Alisha , Darst Burcu F. , Wilkens Lynne R. , Marchand Loïc Le , Lilja Hans , Conti David V. , Haiman Christopher A.
Published: May 2023

AbstractBackground:
Studies in men of European ancestry suggest prostate-specific antigen (PSA) as a marker of early prostate cancer development that may help to risk-stratify men earlier in life.
Methods:
We examined PSA levels in men measured up to 10+ years before a prostate cancer diagnosis in association with prostate cancer risk in 2,245 cases and 2,203 controls of African American, Latino, Japanese, Native Hawaiian, and White men in the Multiethnic Cohort. We also compared the discriminative ability of PSA to polygenic risk score (PRS) for prostate cancer.
Results:
Excluding cases diagnosed within 2 and 10 years of blood draw, men with PSA above the median had a prostate cancer OR (95% CIs) of 9.12 (7.66–10.92) and 3.52 (2.50–5.03), respectively, compared with men with PSA below the median. A PSA level above the median identified 90% and 75% of cases diagnosed more than 2 and 10 years after blood draw, respectively. The associations were significantly greater for Gleason ≤7 versus 8+ disease. At 10+ years, the association of prostate cancer with PSA was comparable with that with the PRS [OR per SD increase: 1.88 (1.45–2.46) and 2.12 (1.55–2.93), respectively].
Conclusions:
We found PSA to be an informative marker of prostate cancer risk at least a decade before diagnosis across multiethnic populations. This association was diminished with increasing time, greater for low grade tumors, and comparable with a PRS when measured 10+ years before diagnosis.
Impact:
Our multiethnic investigation suggests broad clinical implications on the utility of PSA and PRS for risk stratification in prostate cancer screening practices.
Data from A Cross-Sectional Study of the Prevalence of Anal Dysplasia among Women with High-Grade Cervical, Vaginal, and Vulvar Dysplasia or Cancer: The PANDA Study
Authors: Batman Samantha , Messick Craig A. , Milbourne Andrea , Guo Ming , Munsell Mark F. , Fokom-Domgue Joel , Salcedo Mila , Deshmukh Ashish , Dahlstrom Kristina R. , Ogburn Mallory , Price Anthony , Fleming Nicole D. , Taylor Jolyn , Shafer Aaron , Cobb Lauren , Sigel Keith , Sturgis Erich M. , Chiao Elizabeth Y. , Schmeler Kathleen M.
Published: May 2023

Background:
High-risk human papillomavirus (HR-HPV) infection is a risk factor for anal cancer, yet no anal cancer screening guidelines exist for women with lower genital tract HPV-related disease. We sought to describe the prevalence of anal HR-HPV or cytologic abnormalities in such women.
Methods:
This cross-sectional study was performed between October 2018 and December 2021. Inclusion criteria were ≥21 years of age and a prior diagnosis of high-grade dysplasia/cancer of the cervix, vagina, or vulva. Participants underwent anal cytology and anal/cervicovaginal HR-HPV testing. Women with abnormal anal cytology were referred for high-resolution anoscopy (HRA).
Results:
324 evaluable women were enrolled. Primary diagnosis was high-grade dysplasia/cancer of the cervix (77%), vagina (9%), and vulva (14%). Anal HR-HPV was detected in 92 patients (28%) and included HPV-16 in 24 (26%), HPV-18 in 6 (7%), and other HR-HPV types in 72 (78%) patients. Anal cytology was abnormal in 70 patients (23%) and included atypical squamous cells of undetermined significance (80%), low-grade squamous intraepithelial lesion (9%), high-grade intraepithelial lesion (HSIL; 1%), and atypical squamous cells-cannot rule out HSIL (10%). Of these patients, 55 (79%) underwent HRA. Anal biopsies were performed in 14 patients: 2 patients had anal intraepithelial neoplasia (AIN) 2/3, 1 patient had AIN 1, and 11 patients had negative biopsies. Both patients with AIN 2/3 had a history of cervical dysplasia.
Conclusions:
Our results suggest an elevated risk of anal HR-HPV infection and cytologic abnormalities in women with lower genital tract dysplasia/cancer.
Impact:
These results add to the growing body of evidence suggesting the need for evaluation of screening methods for anal dysplasia/cancer in this patient population to inform evidence-based screening recommendations.
Data from Association Between Metabolic Syndrome and Risk of Esophageal Cancer: a Nationwide Population-Based Study
Authors: Lee Ji Eun , Han Kyungdo , Yoo Juhwan , Yeo Yohwan , Cho In Young , Cho Belong , Park Jin-Ho , Shin Dong Wook , Cho Jong Ho , Park Yong-Moon
Published: May 2023

AbstractBackground:
Metabolic syndrome (MetS) is believed to increase the risk of esophageal cancer. However, most studies have been conducted in Western countries, focusing on esophageal adenocarcinoma (EAC). We aimed to investigate the association between MetS and risk of esophageal cancer in nationally representative large dataset in Korea, where esophageal squamous cell carcinoma (ESCC) is predominant.
Methods:
We analyzed the health examinations and claims data from the Korean National Health Insurance Service (NHIS). A total of 6,795,738 subjects who received an NHIS provided health examination in 2009 (index year) were included. Cox proportional hazards models were used to estimate multivariable adjusted HRs (aHR) and 95% confidence intervals (CI) for the association of MetS and its components (elevated waist circumference, blood pressure, triglycerides, fasting blood glucose, reduced high-density lipoprotein cholesterol) with the risk of esophageal cancer.
Results:
During a mean (± SD) follow-up of 8.2 (± 1.1) years, 6,414 cases of esophageal cancer occurred. MetS was associated with an increased risk of esophageal cancer (aHR, 1.11; 95% CI, 1.05–1.18). Among the components of MetS, elevated waist circumference (aHR, 1.24; 95% CI, 1.16–1.33), high blood pressure (aHR, 1.29; 95% CI, 1.22–1.37), and fasting blood glucose (aHR, 1.16; 95% CI, 1.11–1.22) were associated with increased risk of esophageal cancer.
Conclusions:
MetS was associated with an increased risk of esophageal cancer.
Impact:
Our findings suggest that individuals with MetS may be at increased risk for esophageal cancer, specifically ESCC. Further studies are needed to establish the relationship between MetS and esophageal cancer.
Data from Associations between Serum 25-Hydroxyvitamin D Levels and Health-Related Quality-of-Life Measures in Patients with Breast Cancer: A Longitudinal Study
Authors: Cross Temara , George Anthony , Attwood Kristopher , Zhang Yali , O'Connor Tracey L. , Barone Nancy , Hulme Karen , Ambrosone Christine B. , Yao Song , Hong Chi-Chen
Published: May 2023

AbstractBackground:
Recent evidence suggests that vitamin D might lower breast cancer mortality. There is also growing interest in vitamin D's potential association with health-related quality-of-life (HRQoL). Associations between circulating 25-hydroxyvitamin D (25OHD) concentrations and HRQoL were examined prospectively among breast cancer survivors at the time of diagnosis and 1 year later.
Methods:
504 women with incident early-stage breast cancer at Roswell Park Comprehensive Cancer Center were included, and 372 patients provided assessments 1 year later. At each timepoint, participants provided blood samples and completed the SF-36 Health Survey, and surveys on perceived stress, depression, and fatigue. Season-adjusted serum 25OHD concentrations were analyzed in relation to HRQoL measures using multivariable logistic regression models.
Results:
Approximately 32% of participants had deficient vitamin D levels at diagnosis, which decreased to 25% at 1 year. Concurrently, although SF-36 physical health summary scores were lower at 1 year, mental health summary scores improved, and levels of depression and perceived stress were lower. In comparison with women with sufficient 25OHD levels (>30 ng/mL) at diagnosis, those who were deficient (<20 ng/mL) had significantly worse HRQoL at diagnosis and 1 year later. Vitamin D deficiency 1 year post-diagnosis was also associated with worse HRQoL, particularly among breast cancer survivors who took vitamin D supplements.
Conclusions:
Breast cancer survivors with vitamin D deficiency were more likely to report lower HRQoL than those with sufficient levels at the time of diagnosis and 1 year post-diagnosis.
Impact:
Our results indicate a potential benefit of vitamin D supplementation for improving breast cancer survivorship.
Supplementary Table S1 from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer
Authors: Wang Jing , Cheng Xiaobo , Jin Yanling , Xia Bili , Qin Ran , Zhang Wei , Hu Huiliang , Mao Xiaoting , Zhou Liting , Yan Jia , Zhang Xiaoyan , Xu Jianqing
Published: May 2023

Representativeness of Study Participants
Supplementary Figure S4 from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer
Authors: Wang Jing , Cheng Xiaobo , Jin Yanling , Xia Bili , Qin Ran , Zhang Wei , Hu Huiliang , Mao Xiaoting , Zhou Liting , Yan Jia , Zhang Xiaoyan , Xu Jianqing
Published: May 2023

Heatmap shows the frequencies of the top 50 TCR clones in CD8+T cells in cell products pre-infusion and PBMCs four weeks post infusion. Scale bar, %.
Data from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer
Authors: Wang Jing , Cheng Xiaobo , Jin Yanling , Xia Bili , Qin Ran , Zhang Wei , Hu Huiliang , Mao Xiaoting , Zhou Liting , Yan Jia , Zhang Xiaoyan , Xu Jianqing
Published: May 2023

Abstract
Purpose:A phase I clinical trial was conducted to assess the safety and feasibility of iNKT cells combined with PD-1+CD8+ T cells in patients with advanced pancreatic cancer and failing the first-line chemotherapy.

Patients and Methods:Fifteen eligible patients were enrolled, of whom nine received at least three cycles of treatment each. In total, 59 courses were administered.

Results:Fever was the most common adverse event, peaking at about 2-4 h after cell infusion and reverting within 24 h without treatment in all patients. Influenza-like reactions such as headache, myalgia, and arthralgia were also observed in 4, 4, and 3 of the patients, respectively. Additionally, vomiting and dizziness were prevalent, while abdominal pain, chest pain, rash, and stuffy nose were rare adverse events, each reported in one patient. Side effects above grade 2 were not observed. Two patients achieved partial regression, while one patient experienced disease progression assessed four weeks after the 3rd course. Three patients are still alive at the time of writing and have progression-free survival longer than 12 months. The overall survival time has been extended to over 12 months in six of the nine patients. No constant changes of CD4+T, B, and NK cells were recorded except for elevated CD8+T cells after the 1st course.

Conclusions:The combination of autologous iNKT cells and PD-1+CD8+ T cells was a safe therapeutic strategy against advanced pancreatic cancer. The patients exhibited a potentially promising prolonged survival time. Further study appears warranted to evaluate the efficacy of these combined cell infusions in pancreatic cancer.
Ubiratan Incomensurável
Authors:   Universidade de São Paulo. Faculdade de Educação, Conrado Andréia Lunkes , Miranda Gustavo Alexandre de ,   Universidade São Judas, Oliveira Zaqueu Vieira ,   Universidade Federal da Integração Latino-Americana (UNILA)
Published: May 2023

A obra é fruto da produção colaborativa de membros do Grupo de Estudo e Pesquisa em Etnomatemática (GEPEm-FE/USP) e de pesquisadores externos ao grupo que mantiveram contato pessoal e acadêmico com Ubiratan D'Ambrosio. Embora Ubiratan seja conhecido pelos seus trabalhos no campo da educação matemática e de seu pioneirismo nas pesquisas em etnomatemática, o livro lançado busca homenagear um pensador transdisciplinar e que foi um catalisador de ideias, práticas, insights e insubordinações. Talvez, por isso, o termo que nos pareceu mais adequado para o título foi “incomensurável” possibilitando ao leitor uma aproximação com o pensamento e filosofia de vida e de educação D'ambrosianos.
Application of planning tools in São Paulo: limits and possibilities for urban planning
Authors:   Universidade de São Paulo. Faculdade de Arquitetura e Urbanismo, Nobre Eduardo Alberto Cusce , Seo He Nem Kim ,   Universidade de Sao Paulo. Faculdade de Arquitetura e Urbanismo
Published: May 2023

The experience of preparing and implementing the 2002 and 2014 Strategic Master Plans (PDEs) in São Paulo is perhaps the most complete example of the inclusion of urbanistic instruments that have penetrated the lexis and strategies of a theoretical and practical renewal movement of the late 1980s in the planning of Brazilian cities. The Movimento pela Reforma Urbana (Movement for Urban Reform), among other political actions, has invested mobilization and formulation energy in urban regulation. This book aims to evaluate if the application of urban planning instruments proposed in the 2002 and 2014 PDEs in the municipality of São Paulo was able to achieve the objectives they were designed for, the fulfillment of the guidelines to which they were related. Moreover, it does so through research that mobilizes indicators and closely and critically monitors their implementation.
Ações didáticas e formativas em línguas estrangeiras: caminhos para a internacionalização de instituições de ensino superior
Authors:   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas, Albuquerque-Costa Heloisa , Mayrink Mônica Ferreira ,   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas
Published: May 2023

O papel dos centros universitários de línguas nas Instituições de Ensino Superior (IES) no Brasil e no exterior tem se mostrado cada vez mais relevante, por sua contribuição para a difusão e formação plurilíngue de estudantes, docentes e funcionários técnico-adminsitrativos e de todos aqueles que estão direta ou indiretamente envolvidos no processo de internacionalização dessas instituições. É nesse contexto que o presente livro reúne reflexões sobre os trabalhos, formações e pesquisas desenvolvidos por colegas de diferentes IES, brasileiras e estrangeiras. O compartilhamento das experiências realizadas mostra, no seu conjunto, a diversidade de ações que podem colaborar com o fortalecimento dos centros universitários em ensino, pesquisa e extensão. Esperamos que estas leituras possam contribuir para a ampliação das ações de internacionalização desenvolvidas no âmbito das universidades, colaborarando para o desenvolvimento de políticas linguísticas plurilíngues que atendam às demandas da comunidade acadêmica.
The gator grapnel: pedal anchoring in the American alligator (Alligator mississippiensis)
Authors: Walter Collin , Cramberg Michael , Young Bruce A.
Published: May 2023

To resist forward displacement of their body during non-locomotor behaviors such as feeding, American alligators (Alligator mississippiensis) hold their hindfeet vertical, then push the foot into the substrate so that the dorsum of the foot forms a contact area with the substrate. Herein this form of bracing is termed pedal anchoring. The purpose of the present study was to describe pedal anchoring and to demonstrate whether it entailed interaction between the hindfoot (pes) of Alligator and the substrate that differed from the interactions seen during locomotion. Alligator tracks were studied in the wild, during controlled field trials, and on a mud trackway in the laboratory; in each setting locomotor and pedal anchoring tracks were photographed, cast in Plaster of Paris, then features of the casts quantified. Statistical analysis demonstrated greater variation in the wild tracks, presumably reflecting the larger size and velocity ranges of the alligators involved, and suggested that the mud trackway used during the locomotor trials did not create significant artifact. Tracks produced during locomotion and pedal anchoring by the same alligators, on the same substrate, yielded significantly different quantitative features, different matrices of Pearson correlation coefficients, and different patterns of character distribution following Principal Component Analysis. These results all support the conclusion that pedal anchoring involves fundamentally different interaction between the pes and the substrate than occurs during locomotion.
Reflections on the Governance Function of Compulsory Dispute Settlement in the Legal Order for the Ocean
Authors: Roland Holst Rozemarijn J.
Published: May 2023

This article takes the fortieth anniversary of the United Nations Convention on the Law of the Sea as an opportunity to reflect on the role that the compulsory dispute settlement system under Part XV of the Convention plays in maintaining the legal order for the ocean. It posits that, in addition to the more traditional understandings of the dispute settlement function and law-ascertainment function of international adjudication, a clear governance function can be discerned. By developing a three-fold typology of ways in which this governance function manifests itself in the use and exercise of compulsory jurisdiction under Part XV, the aim is to shed light on the multifaceted role of compulsory dispute settlement in maintaining the legal order for the ocean in a way that accounts for the changing expectations of States Parties over time.
Viola suavis subsp. naqshii: a new taxon from Kashmir Himalaya, India
Authors: GANIE AIJAZ H. , ISLAM TAJAMUL , Anzar Ahmad Khuroo  , Bilal A. Tali
Published: May 2023

Viola suavis subsp. naqshii (Violaceae) from Kashmir Himalaya, India is described here. The new taxon is based on characters like linear-lanceolate stipules with long fimbriae, position of bracteoles on peduncle and curved nature of the spur. Comparison of diagnostic characters of this new taxon with closely related taxa and photo-illustrations are also provided to facilitate field identification.
Note on the typification of the name Enneastemon seretii var. tisserantii Le Thomas (Annonaceae)
Authors: HOLSTEIN NORBERT
Published: May 2023

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Sharing 5G Antenna with Transmission Tower: Mounting Height, Arrangement, Electromagnetic Interference and Overall Safety
Authors: Xu Weizhou , An Zengju , Hu YaShan , Tong Teng
Published: May 2023

The demand for communication base stations in the 5G era has increased dramatically, the current large-scale transmission towers are important carrier for 5G equipment sharing construction. For the transmission system, the current and previous load code for the design of overhead transmission
line in China are investigated. Different wind load specification on the conductors, ground wires and 5G equipment on the transmission towers are studied in finite element coupling model. In addition, the influence of soil and electromagnetic is also considering in calculation model. According
to mechanical and simulation model, the structural response of the transmission tower with sharing 5G antenna including different mounting height and arrangement is discussed. Finally, comparison on maximum stress ratio of different horizontal span and overall safety of shared tower is evaluated.