bluuebunny/crossref_metadata_2025 huggingface dataset:
Association rule mining framework for financial credit-risk analysis in peer-to-peer lending platforms
Authors: Tanantong Tanatorn , Loetwiphut Pakin
Published: May 2024

This study demonstrates a comprehensive framework for financial credit-risk analysis in the context of peer-to-peer (P2P) lending, which is a rapidly expanding industry that enables people to lend and borrow money not using conventional financial institutions. However, the considerable default risk associated with P2P lending shows serious difficulties for investors. Difficulties can be overcome through a framework based on feature selection and data discretization approaches for mining association rules from P2P lending data. Providing useful information for credit-risk analysis in P2P lending, obtained association rules can be used to identify trends and connections in the data that indicate a borrower’s creditworthiness and likelihood of payback.
Evaluation of teaching quality in mathematical courses using relative important index: A case study in Neijiang Normal University
Authors: Qin Ya , Rahayu Mohd Hashim Siti , Sulaiman Jumat
Published: May 2024

Evaluation of teaching quality is an essential part of classroom teaching. The key to evaluation is to choose an appropriate evaluation tool and assign reasonable weights to its evaluation indexes. This study chooses reformed teaching observation protocol (RTOP) as an evaluation instrument to measure the relative importance of RTOP factors in mathematical courses. To achieve this goal, the relative importance index method was adopted to determine the values of relative importance among items. The indexes were ranked according to values. The sample of this study consisted of 30 mathematics teachers and students. All relative importance values were greater than 0.5, which indicates that items are medium to high level in importance. Furthermore, the ranking results showed that the factor lesson design and implementation ranked first, followed by propositional knowledge and procedural knowledge, while factor communicative interactions ranked last. The findings also show that lesson design and implementation are the most important factors in ensuring the teaching quality of mathematical courses among the respondents.
Convolutional neural network for wearable fall detection systems
Authors: Khawnuan Uttapon , Sittiwanchai Teppakorn , Yodpijit Nantakrit
Published: May 2024

Fall accidents are a common cause of critical injuries among older adults. Therefore, fall detection systems have garnered considerable attention in research and industry. Feature extraction is the key for detecting falls, but it is time-consuming and tedious process. Deep learning can autonomously extract features from raw sensor data. In this study, we proposed a fall detection algorithm for wearable devices using a convolutional neural network (CNN) to differentiate falls from activities of daily living. The proposed model achieved over 99% metrics (sensitivity, specificity, precision, accuracy, and F1 score) by evaluating two different public datasets and provided better classification performance compared to other fall detection models in the same dataset. The higher CNN performance was recognized without requiring complex data preparation and manual feature extraction. Results from this study could induce CNN through the application of classification problems in technological environments.
Reforming time measurement of hydrophobic and hydrophilic insulator surface via centroid tracking
Authors: Sonkaeo Poohthip , Bunnun Pished , Techawatcharapaikul Chanchai
Published: May 2024

Flashover between insulator surfaces is the most serious issue impacting power system stability related to power failures. It is caused by insulator surface degradation, which causes a flashover loss in insulation efficiency due to a change in the hydrophobicity class (HC) described in IEC TS 62073. The surface tension method is one of the measurement techniques used in this study. This study aimed to research an algorithm for transitioning from conventional measurement methods to a suggested approach for classifying surface tension based on the reforming time that applies to the centroid tracking technique. This research provides manual input for the automated image processing method. The main method is centroid tracking segmentation in a wet area (CTSWA). The comparative timing between adjacent manual frames was examined, yielding results known as ground truth (GT), and our approach (CTSWA) was demonstrated. Most results had a reforming time variance of less than 3% compared to GT. The use of the studied method yields three benefits, including automatic reforming time verification, which can produce acceptable results from more sensitive and reliable insulator inspections. It can also be applied to preventive maintenance planning (PM). Additionally, it reduces the limitations of human decision-making.
Feasibility and kinetic study of electrocoagulation with enhanced flocculation-flotation in removal of color from synthetic dye
Authors: Simbuluk Rose Artika , Niza Noorzalila Muhammad
Published: May 2024

In electrocoagulation, the gas bubbles develop as bubble nuclei, grow in size, break off from the electrode surface and rise in the liquid. Unfortunately, over time, the gas bubbles tend to adhere and accumulate on the electrode surface, deactivate the parts of the electrode surface that reduce the mass transfer of ions. This paper aimed to investigate the feasibility of electrocoagulation with enhanced flocculation-flotation to remove color from synthetic dye. Vibration of plates was utilized in electrocoagulation treatment, with the variables studied including pH (pH 5 and pH 9), vibration intensity (1.5 – 3.5 Volts), current intensity (0.5 – 2.5 A) and operating time (15 – 60 min). From the results, the optimum color removal percentage was 74.76%, achieved at a pH of 9 with optimum vibration and current intensities of 2.5 V and 2.5 A, respectively. For the kinetic study, the rate obtained for the highest R² value was the first-order reaction with a rate constant of 0.0037 min⁻¹ at acidic pH and 0.0022 min⁻¹ at alkaline pH. The vibration of plates enhanced the rate of coagulant ions as well as bubbles dispersion during the treatment due to the oscillation of plates, which generated a stirring mechanism around the electrode plates.
Development of isolated panduratin A-loaded solid lipid nanoparticles as a transdermal delivery system for cosmeceutical products
Authors: Rangsimawong Worranan , Jitsaeng Kusuma , Duangjit Sureewan , Sritananuwat Phaijit , Opanasopit Praneet
Published: May 2024

Panduratin A (PA), isolated from Boesenbergia rotunda (L.) Mansf., is a cyclohexenyl chalcone derivative with low water solubility, from which a suitable transdermal delivery system could be developed to improve skin penetration. Solid lipid nanoparticles (SLNs) are carriers for lipophilic drugs to penetrate the skin layers. Therefore, the objective of this study was to develop SLN containing PA as a transdermal delivery system. Cytotoxicity studies in skin cells, (normal human fibroblasts (NHFs) and human immortalized keratinocytes (HaCaTs),) were evaluated. The PA-loaded SLN formulations were formulated and characterized. From the results revealed that PA was not toxic to NHF and HaCaT cells at 1 µg/mL concentrations, indicating no cytotoxicity of skin cells. SLN formulation 0.1%w/v of PA-loaded SLN (SLN4) exhibited favorable properties such as the nanometer size, negative zeta potential, and the highest entrapment efficiency at 99.81%. The release and skin permeation study showed that PA from SLN4 was released from and permeated through skin better than oil (control) at all sampling times. In conclusion, PA has no skin cell cytotoxicity and is suitable to be used as a cosmeceutical ingredient. SLN4 plays a ideal role as a transdermal delivery system of PA, resulting from its suitable physicochemical properties and ability to permeate the skin.
Formulation and characterization of piroxicam/cyclodextrin taste masked oral lyophilisates
Authors: Saokham Phennapha , Chaichit Siripat , Burapapadh Kanokporn
Published: May 2024

Oral lyophilisates are one of the orodispersible tablets produced by lyophilization technique. Due to their porous structure, they instantly disintegrate when contacting saliva. Generally, they are suitable for drugs with a short onset of action, such as nonsteroidal anti-inflammatory drugs (NSAIDs). Therefore, formulations of piroxicam lyophilisates and their properties were investigated. Because piroxicam is classified as a low solubility but high permeability drug, a solubility enhancing agent should be included in the formulation. The influence of β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) on disintegration time and morphology of piroxicam lyophilisates was studied. Furthermore, the satisfactory taste-masking efficiency of HPβCD in piroxicam lyophilisates was studied by sensory test. The effect of matrix polymer mixtures on disintegration time was previously evaluated. The appropriate ratio of polymer mixture, i.e., gelatin and hydroxypropyl methylcellulose (HPMC), provided lyophilisates with the fastest disintegration time (<30 s) was designated for further studies. The presence of both CDs decreased disintegration time and modified the surface and matrix of lyophilisates. With the theoretical study based on molecular mechanics methods and the investigation through the chemical shift of protons using nuclear magnetic resonance (NMR), piroxicam formed inclusion complexes with both βCD and HPβCD. Dissolution profiles of piroxicam/HPβCD lyophilisates revealed improved piroxicam solubility by inclusion complex formation. Finally, the piroxicam/HPβCD lyophilisates demonstrate the bitterness suppression in healthy volunteers.
Design and manufacture of gelatin-alginate scaffolds for tissue engineering based on three-dimensional extrusion bioprinting
Authors: Nguyen Dung Quoc , Phan Nghia Thi Hieu , Nguyen My Thi Ngoc , Tran Ha Le Bao
Published: May 2024

Scaffolds play an important role in tissue engineering because they can provide the framework for cell proliferation, tissue creation, and organ regeneration. In this study, we used extrusional three-dimensional (3D) bioprinting technology to generate three scaffolds from gelatin, alginate, and CaCl2, where F6 was a scaffold made from 10% gelatin, 10% alginate, and 60 mM CaCl2; F7 was a scaffold made from 10% gelatin, 10% alginate, and 70 mM CaCl2; and F8 was a scaffold made from 10% gelatin, 10% alginate, and 80 mM CaCl2. They were crosslinked with CaCl2 at 100 mM, aiming to enhance their stiffness. The 3D-printed scaffolds were evaluated for four properties: mechanical testing, FTIR analysis, in vitro cytotoxicity, and cell viability. The results showed that the stiffness of the F8 scaffold was the greatest compared with the other two scaffolds. In general, the crosslinked scaffolds were better than the uncrosslinked scaffolds. For in vitro cytotoxicity test, all the scaffolds showed non-cytotoxic. Moreover, cell viability within the scaffolds printed from cell-laden bio-inks was observed 24 hours after printing and returning to culture conditions. Designing and generating 3D-printed scaffolds is fundamental to future research applications in tissue engineering.
Mediating role of patient trust in the impact of perceived physician communication on treatment adherence and its implication in healthcare industry
Authors: Chikodiri Nwosu Laurine , Iruoghene Edo Great , Alpha Jalloh Abdulai
Published: May 2024

This study investigated the relationship between perceived physician communication and treatment adherence and the mediating role of patient trust in the relationship. Although various studies on the influence of modifiable factors on treatment adherence have been carried out, the specific pathways via, which such communication promotes adherence, are less known. Data was collected from 231 outpatients via an online survey and analyzed through regression analysis using Hayes process macro. Although the results showed no statistically significant direct effect between perceived physician communication and treatment adherence, patient trust was shown to fully mediate the indirect effect of the relationship. The study highlighted the importance of trust in patient–physician relationships and how it influenced treatment adherence. The findings emphasized the need for patient-centered communication approaches that enhance mutual understanding and shared decision-making. It also underscored the need for further research on the ways through which patient trust is influenced by physician communication and how to develop and implement effective communication interventions that enhance trust and improve treatment adherence among patients. Patients’ feedback on their perceptions of physician communication could be gathered and used to identify areas for improvement and target training efforts.
Implementasi Pendidikan Karakter Dalam Pembentukan Perilaku Mandiri Taman Kanak-Kanak Maitreyawira Ketapang
Authors: Susanti Susanti , Hosan Hosan , Sonika Sonika
Published: May 2024

This research is motivated by the independent attitude of Maitreyawira Kindergarten School Ketapang children who are influenced by the implementation of character education in schools. Therefore, this study aims to find out the method of implementing character education and how its implementation can shape the independent behavior of children in Maitreyawira Kindergarten School Ketapang. The method used is qualitative research through survey and observation methods. The research subject was the observation of several children, then interviews were conducted with the parents of the children and the teachers who taught the children. Data collection instruments were in the form of interview results, documentation in the form of photographs of children's and teacher's activities, and field notes (anecdotes). From the results of observations, four categories were obtained to assess children's independence, namely Belum Berkembang (BM), Mulai Berkembang (MB), Berkembang Sesuai Harapan (BSH), and Berkembang Sangat Baik (BSB). The results of the research on the implementation of the independent behavior of the Maitreyawira Kindergarten School Ketapang children were assessed from 7 indicators, with the BM and MB categories at 0%, the BSH category at 64%, and the BSB category at 36%. The results of this study are expected to be useful as input in implementing character education in schools. The conclusion of this study shows that the implementation of character education has succeeded in shaping children's independent behavior in their daily lives.
Peran Guru dalam Meningkatkan Minat Belajar Siswa Pada Mata Pelajaran Pendidikan Agama Buddha Kelas IX di SMP Metta Maitreya Pekanbaru
Authors: Wahyuni Natalia , Jelita Rida , Tikno Eko Wahyono
Published: May 2024

This study is entitled “Teacher’s role to improve student’s learning passion in Buddhist Religion Grade IX at SMP Metta Maitreya Pekanbaru. This study is held at SMP Metta Maitreya Pekanbaru to discuss about the teacher’s role as informator, educator, and motivator in improving learning passion for grade IX students in SMP Metta Maitreya Pekanbaru. There are problem identification from this study which are how the teacher’s role as motivator to improve the learning passion and what the supporting and obstacle factors of the teacher as a motivator to improve the learning passion. The goal of this study is to acknowledge the teacher’s role as motivator to improve the learning passion and to discover the support and obstacle factors of the teacher’s role to improve the learning passion in Buddhist religion for the grade IX students of SMP Metta Maitreya Pekanbaru. This study uses descriptive analysis methods with qualitative approach. The technical of data collection is to observe the interview and documentation. The result that could be seen as the study is : 1) to use various techniques in teaching, 2) to make competition, 3) to evaluate, 4) to scoring, 5) to announce the result of lesson, 6) to give the reward, 7) to praise the students, 8) to punish the ones who don’t do the task. Meanwhile the supporting factors are students’ health, the seriousness will of learning from the students, teacher’s competence and qualification. The obstacle factors are lacking in giving appreciation to students, the low understanding of topics by the students, and also the less availability of the school facility.
Pentingnya Evaluasi Pembelajaran Bagi Guru Pendidikan Agama Buddha dan Budi Pekerti di Kelas IX A SMP Metta Maitreya
Authors: Sutikno Yadi , Mariani Mariani , Neli Neli
Published: May 2024

Based on the results of the initial observations above, it was found that teachers need to improve their learning evaluations and it is important to carry out research on learning evaluations. Based on these observations, research will be carried out regarding the importance of learning evaluation for teachers of Buddhism and Character education in class IX A of Metta Maitreya Junior High School. This study uses a qualitative method. The time for carrying out this research is January to March 2024. The research location is Metta Maitreya Junior High School which is located on Jalan Tuanku Tambusai, Puri Nangka Sari Complex, Pekanbaru. The data sources come from the Principal of Metta Maitreya Junior High School, two Buddhist and Character Education teachers, two students, and parents. Data collection techniques through observation, interviews and documentation. The results of this research are 1. to find out whether the assessment carried out by the teacher is systematic, continuous and comprehensive for students to obtain information about students' abilities (learning outcomes) in achieving learning goals, 2. can increase teacher creativity because when creating questions tests, teachers think creatively to produce problems or questions that must be answered by students, 3. Learning evaluations can make teachers self-reflect on whether their learning methods need to be improved or not, 4. can improve the quality of teacher learning in the classroom.
Penerapan Manajemen Berbasis Buddhis Dalam Toleransi Kehidupan Beragama Pada Umat Vihara Prajna Maitreya Sungai Raya Kubu Raya
Authors: Edy Edy , Sonika Sonika
Published: May 2024

This study aims to find out how the Implementation of Buddhist-Based Management in Tolerance of Religious Life in the Prajna Maitreya Sungai Raya Kubu Raya Temple's Congregation Data collection techniques with observation, interviews, documentation, and triangulation. Data analysis techniques with interactive models (Miles and Huberman, 1994: 12), through data reduction, data presentation, and conclusion/verification. The validity of the data is carried out by validating concepts in the form of triangulation and member checks. From the results of the research that the application of Buddhist-based management is more about implementing self-management in good behavior, being polite, being able to yield and being patient in solving every problem to create a peaceful, harmonious and harmonious life so as to create a high sense of tolerance in religious life.
Signifikansi Pembelajaran Inkuiri Dengan Konsep Ehipassiko Dalam Pendidikan Buddhis
Authors: Ratri Asa Murti Suryaning , Widiyono Widiyono , Bramantyo Hastho
Published: May 2024

Education is a process of developing reasoning power, skills, and morality to develop the potential of every human being. Education makes a very big contribution to the progress of a nation. The efforts to improve education in Indonesia are by moving all the components that make up a quality system in education. The research used in this study is library research or library research, namely research conducted by collecting data or scientific writings that aim to be research objects or data collection that is of a literary nature. The discussion in this study was carried out using the checklist or synthesize checklist method which was derived from text, context, and discourse. The inquiry learning model with the ehipassiko concept has not been implemented yet because there is still a lack of understanding of how these two concepts work. Even though these two concepts have a lot in common, it is still very difficult to do because it requires proper understanding and strategies that are in accordance with these two concepts. So that the collaboration or combination of these two teaching models will be successful.
Preparation of administrative maps in community service activities in Sulaho Village, Lasusua District, North Kolaka Regency, Southeast Sulawesi
Authors: Syahrul  , Rembah Rina , Poalahi Salu Sahrul , Arif Arif , Nurfasiha Nurfasiha , Hasriyanti Hasriyanti , Yatjong Isramyano , Kumalasari Rizki , Ode Dzakir La , Suwarto Suwarto
Published: May 2024

Peta adalah gambaran permukaan bumi yang ditampilkan dalam dua dimensi.Peta digunakan sesuai dengan keperluan dan kebutuhan dari pengguna. Peta Administratif di ruang publik akan memberikan kemudahan bagi masyarakat desa, khususnya bagi warga baru desa tentang keadaan desa yang ditinggalinya. Desa Sulaho, Kecamatan Lasusua, Kolaka Utara merupakan desa dengan warga desa yang saling berjauhan dengan tiap dusunnya dan memiliki warga dengan status sebagai warga pendatang. Tujuan dari pengabdian yang dilakukan pada desa ini agar warga desa mudah dan bisa mengenal desanya melalui informasi yang dapat dilihat pada peta administratif yang dibuat. Peta Administratif disimpan dan dipasang di tempat-tempat ruang publik seperti di halaman masjid, kantor desa, persimpangan jalan dan ditempat ramai lainnya. Selain itu, peta administratif ini akan memberikan kenampakan wilayah desa yang sebagian besarnya adalah wilayah pertambangan. Pengabdian masyarakat ini dilakukan pada dusun IV Desa Sulaho, Lasusua, Kolaka Utara. Kegiatan ini didanai melalui dana dari program studi dan sebagian dari swadaya masyarakat. Hasil dari pengabdian ini dapat dirasakan oleh warga desa Sulaho terutama bagi mereka yang memiliki keterbatasan akses informasi dan kesibukan pekerjaan sebagai nelayan dan penambang. Kegiatan pengabdian ini juga dapat membantu pemerintah setempat dalam pemetaan warga terdampak tambang dan lokasi desa yang mengalami kerusakan akibat aktivitas di desa ini.
Clean and Healthy Living Behavior as Health Promotion for Stunting Prevention
Authors: Cinu Surahman , Zainul  , Febriyansyah Dermawan Aji , Halima Nur , Jannah Raodatul , Zahraini A , Jamaluddin Indar Ismai
Published: May 2024

This community service aims to campaign for Clean and Healthy Living Behavior (PHBS) in an effort to prevent stunting of babies and toddlers in Ogolugus Village, Ampibabo District, Parigi Moutong Regency, Central Sulawesi Province. The community service (PKM) carried out is an educational health promotion campaign related to PHBS, namely environmental service, tree planting and plant maintenance, making vertical gardens, and environmental planning competitions to welcome World Food Day. Apart from that, assistance was also provided to the village of Posyandu with the installation of PHBS posters in the village meeting hall. It was concluded that health promotion activities regarding PHBS in Ogolugus Village had been carried out well and according to implementation targets. Activities can be carried out optimally because of the ease of obtaining the necessary tools and materials, as well as the support of the village government and community.
Moderasi Beragama
Authors: Oskar Gultom
Published: May 2024

Abstrak
Moderasi beragama menjadi suatu cara pandang, sikap, dan perilaku yang selalu mengambil posisi di tengah-tengah, bertindak adil, dan tidak ekstrem dalam beragama. Tujuan dari penulisan ini adalah mengetahui moderasi beragama sebagai cara pandang mengamalkan ajaran agama di Indonesia dalam perpektif fenomenologi agama. Bagaimana penerapan ajaran agama diamalkan dengan cara pandang moderat untuk dapat hidup berdampingan secara damai dengan agama-agama lain sehingga tidak menciptakan benturan benturan yang dapat menyakiti orang lain yang tidak sealiran dan sepemahaman dengan kita dan bagaimana Gereja Katolik menyikapi terkait dengan moderasi beragama di Indonesia. Pemahaman dan perilaku moderasi beragama yang ditawarkan diharapkan dapat menjadi solusi atas masalah yang saat ini dihadapi bangsa Indonesia terkait dengan isu agama. Metode penelitian yang digunakan adalah penelitian kualitatif dengan melakukan studi kepustakaan.
Gereja Asia dalam Konteks Perkembangan Teknologi Informasi dan Komunikasi Serta Pandemi Covid-19
Authors: Felix Mahendra  , Adolvus Stevanus  , Seratinus Jong
Published: May 2024

Penelitian ini bertujuan untuk meneliti kecemasan dan peluang Gereja Asia di dalam konteks perkembangan teknologi informasi dan komunikasi serta pandemi Covid-19. Penelitian ini berangkat dari kesadaran para peneliti bahwa kehidupan manusia dewasa ini tidak dapat dipisahkan dari kehadiran Teknologi Informasi dan Komunikasi(TIK) sebagai sarana untuk menunjang berbagai aktivitasnya sehari-hari. Intensitas yang tinggi dalam penggunaan sarana ini menunjukkan bahwa teknologi ini telah menempati peran sentral dalam kehidupan manusia. Gereja Katolik di Asia dewasa ini turut dihadapkan dengan realitas tersebut. Tugas dan tanggung jawab sebagai seorang yang telah memperoleh anugerah pembaptisan (menguduskan, mewartakan maupun melayani) sudah semestinya dilakukan dalam penggunaan TIK. Tulisan ini bertitik fokus pada pembahasan mengenaiTIK yang menjadi tantangan bagi Gereja Katolik di Asia di tengah masa pandemi, selain daripada konteks lain yang juga dihadapi olehnya(perjumpaan budaya-budaya, agama-agama dan kaum marginal). Penelitian ini menggunakan metode penelitian deskriptifkualitatif. Data dihimpun dari dokumen-dokumen Gereja Katolik sebagai data primer dan jurnal-jurnal bereputasi sebagai sumber sekunder.Penelitian ini menemukan bahwa kabar bohong (hoax), ujaran kebencian dan kecenderungan narsistik menjadi tantangan utama penggunaan TIK masa kini. Meski demikian, TIK memberi banyak peluang bagi GerejaKatolik di Asia dalam menyuarakan Kabar Gembira baik dalam tindakan pewartaan, pengudusan dan pelayanan melalui media-media yang ada.
“Meup Onle Ate, Tah Onle Usif”: Lensa Filosofis Memahami Orang Dawan Dan Dunia Kerjanya
Authors: Agrindo Zandro Raioan
Published: May 2024

Artikel ini menguraikan profil manusia suku Dawan dalam dua dimensi, yaitu antropologis dan ekologis. Uraian dengan dua dimensi ini bermuara pada satu esensi yang disebut dengan ‘dunia kerja’. Dua dimensi ini dilihat dalam lensa filosofis kebudayaan yang berwujud falsafah hidup orang Dawan dalam dunia kerja. Bagi orang Dawan, bekerja merupakan unsur esensial dari keberadaannya. Dengan bekerja manusia Dawan dapat mewujudkan siapa dirinya dan dapat pula menyatakan relasinya dengan alam sekitar. Metodologi yang digunakan dalam artikel ini adalah studi filsafat fenomenologis yang dipadukan dengan studi kepustakaan. Artikel ini menemukan bahwa bagi orang Dawan, bekerja bukan saja untuk mencari makan, tetapi pertama-tama sebagai bentuk perwujudan identitas diri yang sejati serta momen di mana manusia Dawan dapat berelasi dan menyatu dengan alam. Sumbangan khas dari artikel ini adalah semua manusia, secara khusus manusia Dawan, harus memiliki kehendak untuk bekerja. Bukan saja untuk makan dan minum, lebih dari itu bekerja harus diselaraskan dengan perwujudan diri yang utuh dan saat di mana manusia dapat menyatu dan berelasi dengan alam sekitar.
Diskursus Homo Digitalis dalam Tinjauan Dimensi Material dan Substansial Kebudayaan
Authors: Agrindo Zandro
Published: May 2024

Fokus studi ini ialah menguraikan konsep homo digitalis dalam tinjauan dimensi material dan substansial kebudayaan. Perubahan senantiasa dialami oleh makhluk berbudi, yakni manusia. Dengan perubahan itulah saat ini manusia telah menjadi insan yang tidak lagi disebut homo sapiens melainkan homo digitalis. Kelahiran homo digitalis bersamaan dengan teknologi digital yang menemani dan mewarnai hidupnya sehari-hari. Dengan teknologi tersebut, seorang homo digitalis merajut dan memaknai kenyataan sekitarnya sebagai budayanya sendiri. Homo digitalis yang hadir di dunia secara eksistensial memiliki kebudayaannya sendiri. Untuk itu, studi ini hendak menguraikan homo digitalis dalam tinjauan dimensi material dan substansial kebudayaan sehingga darinya dapat ditemukan segala sesuatu yang berkenaan dengan budaya homo digitalis. Metode yang digunakan dalam studi ini adalah metode kualitatif melalui studi kepustakaan. Studi ini menemukan bahwa homo digitalis memiliki kebudayaan yang unik dan kompleks. Sumbangan dari studi ini ialah suatu khazanah pengetahuan tentang kebudayaan homo digitalis yang sejatinya merupakan realitas manusia sejagat dewasa ini.
Accessibility of lung adenocarcinoma screening in the Chinese population: an exploratory analysis
Authors:   School of Medical Humanities, China Medical University,110122, Shenyang, China, Feng Yangdongping , Peng Miao
Published: May 2024

Objective: Systematic quantification of the accessibility of lung adenocarcinoma screening and surveillance services in the Chinese population, with particular reference to a series of indicators in the Availability dimension. Materials and methods: With reference to the specific contents and indicators involved in the evaluation of cancer screening accessibility by international authorities, including relevant local policy programmes, coverage rates, screening participation and adherence rates and influencing factors, acceptability, and treatment rates. A systematic review approach was adopted to systematically integrate and evaluate the indicators related to lung cancer screening and surveillance in the Chinese population. Results: The literature search resulted in the inclusion of 109 publications. The results of the analysis suggest that cancer screening services in China all have recommendations and practice evaluations of lung adenocarcinoma screening protocols for general risk groups in specific regions and age groups and clear surveillance protocol recommendations for different high-risk groups identified by screening. The annual coverage of primary screening for lung adenocarcinoma is approximately 0.09% nationally among people aged 20-70 years. The overall screening participation rate averaged 53.87; the surveillance adherence rate averaged 29.4%; and the subjective acceptance of methemoglobin testing combined with LDCT spiral lung cancer screening was 98.6% among the urban population at high risk of lung adenocarcinoma in China, as suggested by the analysis of a large national sample. The treatment rate for patients with lung adenocarcinoma detected by screening surveillance in rural populations was above 95%. Conclusion: There is still much room for improvement in the accessibility of lung cancer screening in China's public health services, and the accessibility of lung cancer screening in China's public health services should be continuously improved. At the same time, studies on the accessibility of lung cancer screening in China should continue to be improved.
Role of zinc oxide nanoparticles in alleviating sodium chloride-induced salt stress in sweet basil (Ocimum basilicum L.)
Authors: Hasan Syed Aiman , Khan Adnan , Irfan Mohd
Published: May 2024

In this study, we examined the role of zinc oxide nanoparticles (ZnO NPs) on the growth facet, photosynthetic attributes, lipid peroxidation, electrolyte leakage (EL), and antioxidant activity of basil plants following growth subjected to different levels of sodium chloride-induced salinity [1.0 (control), 2.0, 3.0, 4.0, and 5.0 deci Siemens per meter (dSm–1)]. The foliage of 30-day-old plants was sprayed with an aqueous solution of ZnO NPs [(1.5/2.0 parts per million (ppm)]. Treated plants sampled at 75 days after sowing showed a concentration-dependent response against salinity for all studied growth, photosynthetic attributes, and other biochemical parameters. All growth parameters decreased with increasing salt levels in the soil. However, a direct relationship was observed for lipid peroxidation, EL, and all antioxidant stress markers, and all these parameters increased with the increased salinity levels in the soil. Moreover, ZnO NPs alone (1.5 or 2.0 ppm) or as a follow-up treatment with salinity (2.0 dSm–1 + 1.5 or 2.0 ppm ZnO, 3.0 dSm–1 + 1.5 or 2.0 ppm ZnO, 4.0 dSm–1 + 1.5 or 2.0 ppm ZnO, and 5.0 dSm–1 + 1.5 or 2.0 ppm ZnO) enhanced all the growth and photosynthetic parameters and protected the plants against salinity by reflecting the enhanced activity of antioxidants and decreasing EL and lipid peroxidation. The results of this study confirmed the ameliorating role of ZnO NPs against salt stress and screened out an effective dose of ZnO NPs (2.0 ppm) for growing Ocimum basilicum plant species in saline soil.
Stability-indicating HPLC method optimization using quality by design with design of experiments approach for quantitative estimation of organic related impurities of Doripenem in pharmaceutical formulations
Authors: Praveen Boppy N. V. V. D. , Haridasyam Sharath Babu , Vadagam Niroja , Sara Naveen , Sara Karthik , Tamma Eswarlal
Published: May 2024

Doripenem (DM), an antibiotic used for kidney, lung, and urinary infections, underwent the development of a robust high-performance liquid chromatography (HPLC) technique using the quality-by-design approach. This method, integrating design-of-experiments, detected organic impurities in both drug substances and formulated products. Operating with a C18 analytical column in a binary gradient mode with potassium phosphate buffer (pH 6.1) and acetonitrile as mobile phases, the method ran at a flow rate of 1.20 ml/minutes, with an injection volume of 20-μl and a column temperature of 45°C. Stability testing under various conditions, including hydrolysis, oxidation, heat, humidity, and light exposure, confirmed the method’s reliability without interference. Validation studies, compliant with ICH guidelines, revealed quantitation limits of 0.006%, linearity between 0.060 and 1.800 μg/ml (R2 > 0.999), and recoveries ranging from 96.8% to 99.1%. This HPLC method was effectively used for stability assessment in quality control testing, assessing doripenemic acid, doripenem assay, and organic impurities.
Review on phytochemical constituents and pharmacological activities of genus Galium
Authors: Ali Kanso Mayssaloune , Ali Hijazi Mohamed , El-Lakany Abdalla , Aboul-Ela Maha
Published: May 2024

Medicinal plants are a rich source of phytochemical constituents of diverse structures that are behind their various pharmacological effects. Plants of genus Galium named Bedstraws, family Rubiaceae, are distributed throughout North and South America, Europe, the northern U.S., southern Canada, and tropical Asia. More than 600 species have been used in traditional medicine for treating different ailments. Owing to the valuable published uses of these plant species, and the versatility of their bioactive metabolites such as Galium verum, Galium aparine, Galium mollugo, and G. odoratum, it was deemed interesting to summarize the previous studies done on this genus to discuss the pharmacological profile of all isolated classes of metabolites. The search was adopted using some essential keywords such as Galium, phytochemistry, pharmacology, and biological activity from journals and books in databases such as Scopus, Elton B. Stephens CO, ScienceDirect, Embase, security identifier, and Medline from 1995 to 2024. The results showed that species belonging to Galium have various pharmacological activities including antimicrobial, antioxidant, anti-cancer, immunomodulatory, and anti-inflammatory effects because they are rich in phenolic compounds, iridoid glycosides, anthraquinones, phytosterols, saponins, and essential oils. Accordingly, this review will stimulate the scientific community for further research and boost the discovery of novel bioactive compounds from various species belonging to this genus distributed worldwide.
A generalization of arithmetic derivative to p-adic fields and number fields
Authors:   Department of Mathematics, Utica University, Emmons Brad , Xiao Xiao ,   Department of Mathematics, Utica University
Published: May 2024

The arithmetic derivative is a function from the natural numbers to itself that sends all prime numbers to 1 and satisfies the Leibniz rule. The arithmetic partial derivative with respect to a prime p is the p-th component of the arithmetic derivative. In this paper, we generalize the arithmetic partial derivative to p-adic fields (the local case) and the arithmetic derivative to number fields (the global case). We study the dynamical system of the p-adic valuation of the iterations of the arithmetic partial derivatives. We also prove that for every integer n \geq 0, there are infinitely many elements with exactly n anti-partial derivatives. In the end, we study the p-adic continuity of arithmetic derivatives.
Deepfake forensics: a survey of digital forensic methods for multimodal deepfake identification on social media
Authors: Qureshi Shavez Mushtaq , Saeed Atif , Almotiri Sultan H. , Ahmad Farooq , Al Ghamdi Mohammed A.
Published: May 2024

The rapid advancement of deepfake technology poses an escalating threat of misinformation and fraud enabled by manipulated media. Despite the risks, a comprehensive understanding of deepfake detection techniques has not materialized. This research tackles this knowledge gap by providing an up-to-date systematic survey of the digital forensic methods used to detect deepfakes. A rigorous methodology is followed, consolidating findings from recent publications on deepfake detection innovation. Prevalent datasets that underpin new techniques are analyzed. The effectiveness and limitations of established and emerging detection approaches across modalities including image, video, text and audio are evaluated. Insights into real-world performance are shared through case studies of high-profile deepfake incidents. Current research limitations around aspects like cross-modality detection are highlighted to inform future work. This timely survey furnishes researchers, practitioners and policymakers with a holistic overview of the state-of-the-art in deepfake detection. It concludes that continuous innovation is imperative to counter the rapidly evolving technological landscape enabling deepfakes.
Identification and analysis of novel recessive alleles for Tan1 and Tan2 in sorghum
Authors: Zhang Lixia , Wang Chunyu , Yu Miao , Cong Ling , Zhu Zhenxing , Chen Bingru , Lu Xiaochun
Published: May 2024

Background

The identification and analysis of allelic variation are important bases for crop diversity research, trait domestication and molecular marker development. Grain tannin content is a very important quality trait in sorghum. Higher tannin levels in sorghum grains are usually required when breeding varieties resistant to bird damage or those used for brewing liquor. Non-tannin-producing or low-tannin-producing sorghum accessions are commonly used for food and forage. Tan1 and Tan2, two important cloned genes, regulate tannin biosynthesis in sorghum, and mutations in one or two genes will result in low or no tannin content in sorghum grains. Even if sorghum accessions contain dominant Tan1 and Tan2, the tannin contents are distributed from low to high, and there must be other new alleles of the known regulatory genes or new unknown genes contributing to tannin production.

Methods

The two parents 8R306 and 8R191 did not have any known recessive alleles for Tan1 and Tan2, and it was speculated that they probably both had dominant Tan1 and Tan2 genotypes. However, the phenotypes of two parents were different; 8R306 had tannins and 8R191 had non-tannins in the grains, so these two parents were constructed as a RIL population. Bulked segregant analysis (BSA) was used to determine other new alleles of Tan1 and Tan2 or new Tannin locus. Tan1 and Tan2 full-length sequences and tannin contents were detected in wild sorghum resources, landraces and cultivars.

Results

We identified two novel recessive tan1-d and tan1-e alleles and four recessive Tan2 alleles, named as tan2-d, tan2-e, tan2-f, and tan2-g. These recessive alleles led to loss of function of Tan1 and Tan2, and low or no tannin content in sorghum grains. The loss-of-function alleles of tan1-e and tan2-e were only found in Chinese landraces, and other alleles were found in landraces and cultivars grown all around the world. tan1-a and tan1-b were detected in foreign landraces, Chinese cultivars and foreign cultivars, but not in Chinese landraces.

Conclusion

These results implied that Tan1 and Tan2 recessive alleles had different geographically distribution in the worldwide, but not all recessive alleles had been used in breeding. The discovery of these new alleles provided new germplasm resources for breeding sorghum cultivars for food and feed, and for developing molecular markers for low-tannin or non-tannin cultivar-assisted breeding in sorghum.
Biodegradation of crystal violet by newly isolated bacteria
Authors: Kwak Soon Jun , Park Jiyul , Sim Yuri , Choi Hisu , Cho Jein , Lee Young-Man
Published: May 2024

Confronting the environmental threat posed by textile dyes, this study highlights bioremediation as a pivotal solution to mitigate the impacts of Crystal Violet, a widely-utilized triphenylmethane dye known for its mutagenic and mitotic toxicity. We isolated and identified several bacterial strains capable of degrading Crystal Violet under various environmental conditions. Newly identified strains, including Mycolicibacterium nivoides, Chryseobacterium sp., Agrobacterium rhizogenes, Pseudomonas crudilactis, and Pseudomonas koreensis demonstrated significant decolorization activity of Crystal Violet, complementing the already known capabilities of Stenotrophomonas maltophilia. Initial experiments using crude extracts confirmed their degradation potential, followed by detailed studies that investigated the impact of different pH levels and temperatures on some strains’ degradation efficiency. Depending on the bacteria, the degree of activity change according to pH and temperature was different. At 37 °C, Chryseobacterium sp. and Stenotrophomonas maltophilia exhibited higher degradation activity compared to 25 °C, while Pseudomonas crudilactis and Mycolicibacterium nivoides did not exhibit a statistically significant difference between the two temperatures. Mycolicibacterium nivoides performed optimally at pH 8, while Pseudomonas crudilactis showed high activity at pH 5. Stenotrophomonas maltophilia’s activity remained consistent across the pH range. These findings not only underscore the effectiveness of these bacteria as agents for Crystal Violet degradation but also pave the way for their application in large-scale bioremediation processes for the treatment of textile effluents, marking them as vital to environmental sustainability efforts.
STUDY OF KAJJALIKODAYA MALAHARA FOR EVALUATION OF WOUND HEALING ACTIVITY
Authors: . Jayalaxmi , MS Krishnamurthy
Published: May 2024

Introduction: Kajjalikodaya malahara, mentioned in the Rasatarangini text, is indicated in different types of wounds like chronic wounds and fistula in ano, which did not respond to other treatment modalities. So, this formulation was selected for the present study. Material and methods: The Kajjalikodaya malahara prepared as per reference -anagni (without fire) and also modified version- agni siddha (with fire) method and subjected for antimicrobial, acute dermal toxicity studies and also screened for wound healing efficacy in excision and incision wound healing models. Results: The trial drug prepared by both methods was found safe in an antimicrobial study and did not reveal any acute dermal toxic conditions. In excision and incision wound healing model showed better therapeutic efficacy. Conclusion: Both formulations were efficient in the wound healing model’s study. Compared to a modified version of the agni siddha test drug, classically prepared anagni siddha was better in therapeutic efficacy.
PHYSICOCHEMICAL AND PHYTOCHEMICAL ANALYSIS OF HERBO-MINERAL HAIR DYE FOR PREMATURE HAIR GRAYING
Authors: Joshi Mrudula , Rasane Shital , Patil Neelesh , Joshi Vinayak
Published: May 2024

Background: Premature Hair Graying (PHG/ Canities) is the burning problem of today’s society. Despite extensive research, the treatment for PHG is still unsatisfactory. Ayurveda considers Palitya (premature hair graying) as an ailment of vitiated Pitta dosha (deranged functional factor of the body responsible for digestion and metabolism). Ayurveda therapeutics can provide the natural solution to this problem without adverse effects and also can prevent the recurrence. Objective: In present research work, attempts are made to formulate unique, safe and effective herbomineral hair dye (Keshranjak yog) an Ayurvedic formulation. The prepared formulation is also evaluated for its efficiency through various organoleptic, phytochemical and physicochemical parameters. Results: The pH of prepared herbomineral hair dye was found to be 6 which is close to neutral; to suit the requirements of different scalp and hair types. Total phenolic content (8.1%±0.7), total flavonoid content (6±1.2) of prepared sample were found to be acceptable and within limit. Conclusion: The dyeing effect of the developed dye may be attributed to keshya (good for hair), Kesharanjak (hair coloring) properties according to Ayurveda and presence of tannins, phenols as per pharmaceutics. Nowadays natural remedies are widely accepted as they are safer with minimal side effects as compared to the chemical hair dye. Kesharanjak yog may provide vital nourishment to the scalp skin and can color the hair in an utmost gentle manner. Due to nontoxic nature can act as public healthcare product.
EXPLORING THE HAEMOSTATIC POTENTIAL OF PANCHAVALKALA KASHAYA AND PANCHAVALKALA AQUEOUS EXTRACT: AN IN VITRO STUDY
Authors: Rose Aiswarya , Satheesan Sreejith
Published: May 2024

Acharya Susrutha under the context of Rakthasthambhanopaya (methods of haemostasis) has explained about the different methods to attain Rakthasthambhana or haemostasis. which include Skandana (clotting of blood), Santhana (uniting), Pachana (ripening or digestive measures) and Dahana (thermal cauterisation). Acharya Susrutha while explaining about agantuja vrana chikitsa (treatment of wound) has explained that ‘Pittavat sheeta kriya’ should be done prior to santhana to mitigate the ‘Kshatoshmana’. So, from this it is evident the primary method of management should be done with sheeta (cold) followed by Kashaya rasa dravya (astringent taste drugs) for Santhana. Panchavalkala is a group drug with sheeta veerya (cold potency) and Kashaya rasa (astringent taste) mentioned in Dalhana commentary for Skandana. This study investigates the haemostatic effect of Panchavalkala Kashaya and Panchavalkala aqueous extract by in vitro method. Preliminary phytochemical screening of both trial drugs was done. A total of 10 samples of healthy human platelet poor plasma were mixed in trial drugs, Prothrombin and Activated Partial Thromboplastin time were determined. Data was analysed using Kruskal Wallis test. Phytochemical analysis confirmed that the Panchavalkala kashaya contain alkaloids, tannins, glycosides and saponins. Panchavalkala aqueous extract sample consist of flavonoids, alkaloids, glycosides, tannins and saponins. LCMS Q-TOF analysis shows the presence of compounds Gallic acid, Epicatechin, Leucocynidin and Procyanidin B1. And the HPLC study confirmed that Gallic acid is an active phytoconstituent present in the Panchavalkala aqueous extract. In the present study the trial group Panchavalkala aqueous extract showed more desirable haemostatic effect than Panchavalkala Kashaya on comparison.