bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Models of Diagnostic Information Granules Generated by Scaling Intuitionistic Fuzzy Sets
Authors: Bryniarska Anna
Published: March 2022

The paper presents a certain class of the mathematical models of diagnostic information granules describing the fuzzy symptoms-faults relationship. A certain fuzzy diagnostic information retrieval system is described as an application of an expert diagnostic system. Symptoms and faults are fuzzy, and with some scaling of the symptom-fault concept pair values. These value pairs can be considered as intuitionistic fuzzy sets for the space of diagnosed objects. In this article, for scaling intuitionistic fuzzy sets (n-ScIFS), the deductive theory is formulated. There the intuitionistic fuzzy sets (IFSs) and the Pythagorean fuzzy sets (PFSs) are generalized to the n-ScIFS objects. The membership and non-membership values, as standard, can be described by the 1:1 scale or the quadratic function scale. However, any power scale n>2 can be used. In this paper, any n-Sc scaling functions retaining the IFSs properties are considered. The n-ScIFS theory introduces a conceptual apparatus analogous to the classical theory of Zadeh fuzzy sets and Yager PFSs, consistently striving, for the first time, to formulate the relational structure of n-ScIFSs as a model of a certain information granule system called here the diagnostic granule system. In addition, power- and linear-repeatable diagnostic granules are defined in the n-ScIFSs structure for serial or parallel diagnosis processes. The information granule base is determined and a diagnostic granule system model produced by this information granule base is shown. Certain algorithms have been given to establish the semantic language of diagnosis describing the system of diagnostic information granules.
Beer Quality Evaluation—A Sensory Aspect
Authors: Habschied Kristina , Krstanović Vinko , Mastanjević Krešimir
Published: March 2022

The world’s beer market has never been more diverse. Most beers are produced in modern and technologically advanced breweries that use high quality raw materials, thus resulting in minor differences of physical–chemical properties between various beers (of the same style). However, consumers focus on constant quality and sensory properties of their chosen beer. Sensory evaluation is not an easy task and involves flexible methods for determination of differences and changes between beers. It is commonly used in breweries to provide constant quality of finished products, but also to ensure the quality of different raw materials (water, malt, hops) and to minimize the influence of the production process on final quality of beer.
In Vitro Qualitative Evaluation of Root-End Preparation Performed by Piezoelectric Instruments
Authors: Bugea Calogero , Berton Federico , Rapani Antonio , Di Lenarda Roberto , Perinetti Giuseppe , Pedullà Eugenio , Scarano Antonio , Stacchi Claudio
Published: March 2022

Although the application of ultrasounds in endodontic surgery allows for effective debridement of the root canal, incorrect device setting or inefficient tips seem to generate cracks during root-end retropreparation. The primary aim of this in vitro study was to establish the presence, or absence, of a correlation between ultrasonic root-end preparation and the formation of cracks. The present study was conducted on human teeth, extracted for periodontal reasons. After root canal treatment, roots were resected 3 mm from the anatomical apex by using a high-speed handpiece and carbide burs. The resected teeth were retroprepared by using an ultrasonic tip (R1D, Piezomed, W&H, Bürmoos, Austria), setting the piezoelectric device at maximum power available for the tip. Time required for the retropreparation was recorded. Before and after retropreparation, all roots were photographed under a stereomicroscope and analyzed by two different operators to evaluate: (a) the presence and extension of dentinal cracks and (b) the morphology of root-end preparation. Finally, piezoelectric tips were analyzed by scanning electron microscopy (SEM) to evaluate morphologic changes after use. A total of 43 single roots (33 with one root canal, 10 with two root canals) were treated. Average preparation time was 1 minute and 54 seconds. None of the roots without initial cracks developed new cracks after retropreparation. Quality of the preparation margins was fairly equal among the prepared specimens. None of the piezoelectric tips broke during instrumentation, and SEM analysis showed minimal surface wear of the tips after performing 11 retropreparations. Within the limits of the present study, the tested piezoelectric system does not seem to represent a major cause for root crack formation. Pre-existing cracks may expand after ultrasound root-end preparation.
Disruption of Colorectal Cancer Network by Polyphyllins Reveals Pivotal Entities with Implications for Chemoimmunotherapy
Authors: Siripuram Ram , Bartolek Zinka , Patil Ketki , Gill Saj S. , Pai S. Balakrishna
Published: March 2022

The prevalence of colorectal cancer has increased world-wide with high rates of mortality and morbidity. In the absence of efficacious drugs to treat this neoplasia, there is an imminent need to discover molecules with multifaceted effects. To this end, we opted to study the effect of steroidal saponins such as Polyphyllins. We performed anticancer activity studies with three analogs of Polyphyllins: Polyphyllin D (PD), Polyphyllin II (PII) and Polyphyllin G (PG). Here we show the potent effect of PD, PII (IC50 of 0.5−1 µM) and PG (IC50 of 3 µM) in inhibiting the viability of colorectal adenocarcinoma cells (DLD-1) and colorectal carcinoma cells (HCT116). PD and PII also showed inhibition of cell proliferation and sustained response upon withdrawal of the compounds when assessed by clonogenic assays in both the cell lines. Elucidation of the molecular mode of action revealed impact on the programmed cell death pathway. Additionally, proteomic profiling of DLD-1 revealed pivotal proteins differentially regulated by PD and PII, including a downregulated peroxiredoxin-1 which is considered as one of the novel targets to combat colorectal cancers and an upregulated elongation factor 2 (EF2), one of the key molecules considered as a tumor associated antigen (TAA) in colon cancer. Entities of cell metabolic pathways including downregulation of the key enzyme Phosphoglycerate kinase 1 of the glycolytic pathway was also observed. Importantly, the fold changes per se of the key components has led to the loss of viability of the colorectal cancer cells. We envision that the multifaceted function of PD and PII against the proliferation of colorectal carcinoma cells could have potential for novel treatments such as chemoimmunotherapy for colorectal adenocarcinomas. Future studies to develop these compounds as potent anti-colorectal cancer agents are warranted.
A Novel Peptide as a Specific and Selective Probe for Klebsiella pneumoniae Detection
Authors: Kim Hyun , Jang Ju Hye , Jung In Young , Cho Ju Hyun
Published: March 2022

Klebsiella pneumoniae is infamous for generating hospital-acquired infections, many of which are difficult to treat due to the bacterium’s multidrug resistance. A sensitive and robust detection method of K. pneumoniae can help prevent a disease outbreak. Herein, we used K. pneumoniae cells as bait to screen a commercially available phage-displayed random peptide library for peptides that could be used to detect K. pneumoniae. The biopanning-derived peptide TSATKFMMNLSP, named KP peptide, displayed a high selectivity for the K. pneumoniae with low cross-reactivity to related Gram-negative bacteria. The specific interaction between KP peptide and K. pneumoniae lipopolysaccharide resulted in the peptide’s selectivity against K. pneumoniae. Quantitative analysis of this interaction by enzyme-linked immunosorbent assay revealed that the KP peptide possessed higher specificity and sensitivity toward K. pneumoniae than commercially available anti-Klebsiella spp. antibodies and could detect K. pneumoniae at a detection limit of 104 CFU/mL. These results suggest that KP peptide can be a promising alternative to antibodies in developing a biosensor system for K. pneumoniae detection.
Treatment, Outcome, and Relapse of Spontaneous and Nonspontaneous Cerebrospinal Fluid Leak
Authors: Tai Yi-Cheng , Tai Yi-Sheng , Ou Chang-Hsien , Lui Chun-Chung , Wang Hao-Kuang , Kuo Hung-Chang , Hsu Shih-Pin
Published: March 2022

Cerebrospinal fluid (CSF) leak can be spontaneous or nonspontaneous. The management options include conservative treatments, blood patch, and surgical repairs. We compared clinical symptoms, image findings, management options, hospitalization, and relapse rates among different causes of CSF leaks. Eighty-one patients were recruited: 20 with spontaneous and 61 with nonspontaneous CSF leaks. Nonspontaneous causes included lumbar puncture, surgery, and trauma. Surgery sites comprised sphenoid, spine, skull base, and calvaria. Spontaneous CSF leak came from the sphenoid or spine. Age, gender, body mass index, initial symptoms, hospitalization, treatment courses, and recurrence rates showed no difference between the groups. The spontaneous group had higher CSF accumulations on their MRIs. MRI pachymeninge enhancement showed the highest sensitivity (78.6%) for intracranial hypotension. Meningitis occurred in 1/3 of sphenoid, skull base, and calvarian surgeries. Earlier reoperation was correlated with shorter hospitalization (r = 0.651), but the recurrence rates were similar. Longer intervals between surgery and CSF leak encouraged reoperation. Among the spontaneous spine and lumbar puncture-related CSF leaks, 57.1% of them responded to 4 days of conservative treatment. Among the trauma-related CSF leaks, 90.9% of them required surgical repair. The demographic data and symptoms were similar in various groups of CSF leak. The symptom onset durations and treatment strategies were different. However, the recurrence rates were similar.
Creativity, Boredom Proneness and Well-Being in the Pandemic
Authors: Brosowsky Nicholaus P. , Barr Nathaniel , Mugon Jhotisha , Scholer Abigail A. , Seli Paul , Danckert James
Published: March 2022

Throughout the course of the pandemic, it has become clear that the strictures of social isolation and various levels of lockdown constraints have impacted people’s well-being. Here, our aim was to explore relations between trait dispositions associated with boredom proneness, self-regulation and well-being using data collected early in the pandemic. Specifically, we explored whether the tendency to engage in everyday creative pursuits (e.g., making your own greeting cards) would act as a prophylactic against poor well-being. Results showed that well-being was higher for those individuals who increased engagement with creative pursuits during the early stages of the pandemic. That is, people who engaged more in everyday creative activities also reported higher levels of self-esteem, optimism, and positive affect. In contrast, those who pursued fewer creative outlets had higher levels of depression and anxiety, were higher in boredom proneness, and reported experiencing more negative affect. As we emerge from the pandemic, these data provide a clue as to how people might plan to cope adaptively with the restrictive circumstances this extreme world event engendered. More generally, these data provide support for the notion that everyday creativity (and not necessarily creative expertise) has positive associations for well-being.
Comparison of the Experimental Measurement Methods for Building Envelope Thermal Transmittance
Authors: Lu Xinrui , Memari Ali M.
Published: March 2022

Building energy consumption and ways to reduce it have drawn increasing attention in recent decades. Thermal transmittance is not only a code-enforced parameter during the design and retrofit phase of building assemblies, but also strongly related to the accuracy of whole-building energy modeling. There are several existing methods to measure the building envelope thermal transmittance, and with the development of new techniques, more practical and precise measurement methods have been explored. The study discussed here focused on comparing methods to measure the building envelope thermal transmittance, both in laboratory and for in-situ measurement. Typical research studies related to the Hot Box Test Method, the Heat Flow Meter Method and the Infrared Thermography Method are described and compared. This paper provides a state-of-the-art review of the up-to-date measurement methods for building envelope thermal transmittance and provides alternatives for engineers, architects and researchers to practically measure the building envelope thermal transmittance.
Numerical Investigation of the Post-Fire Performance of Steel Columns
Authors: Pantousa Dafni , Karavasilis Theodoros , Maraveas Chrysanthos
Published: March 2022

Research on the seismic performance of steel structures has led to the development of improved structures, which minimize structural and non-structural damage and can be reused immediately after an earthquake. Moreover, significant advances have been made for predicting the response of steel members, connections, and structural systems exposed to fire. Nevertheless, the research on the reuse of steel structures after a fire event is limited. A steel structure designed according to the current seismic codes can survive a fire without significant structural damage and may be repaired and reused. Therefore, it is of great importance to study whether the reuse of steel structures after a fire is safe in high seismicity areas. This paper investigates the seismic performance of steel columns that are pre-damaged due to fire. For this purpose, sophisticated finite element models have been developed and validated against experimental data. It was concluded that the models accurately predict the behaviour of beams-columns at elevated temperatures. First, the behaviour of the columns was studied using simplified boundary conditions; the surrounding structure was not included in the numerical model. Thermal-structural analyses were performed to determine the structural damage induced by the fire. Subsequently, the cyclic performance of the columns was investigated, considering both the residual post-fire deformations and the proper material properties. Aiming to obtain more realistic results, the complicated interaction between the heated columns and the surrounding structure was considered in the modelling. For this reason, the fire behaviour of a seismic resistant frame was simulated. Then, the behaviour of fire-damaged columns under cyclic loading was assessed. The analysis of the results demonstrates the effect of the post-fire damage on the cyclic behaviour of columns.
Clinical and Molecular Characteristics of Patients with PLN R14del Cardiomyopathy: State-of-the-Art Review
Authors: Monda Emanuele , Blasi Ettore , De Pasquale Antonio , Di Vilio Alessandro , Amodio Federica , Caiazza Martina , Diana Gaetano , Lioncino Michele , Perna Alessia , Verrillo Federica , Martucci Maria , Munciguerra Orlando , Vergara Andrea , Limongelli Giuseppe
Published: March 2022

The deletion of the arginine 14 codon (R14del) in the phospholamban (PLN) gene is a rare cause of arrhythmogenic cardiomyopathy (ACM) and is associated with prevalent ventricular arrhythmias, heart failure, and sudden cardiac death. The pathophysiological mechanism which culminates in the ACM phenotype is multifactorial and mainly based on the alteration of the endoplasmic reticulum proteostasis, mitochondrial dysfunction and compromised Ca2+ cytosolic homeostasis. The symptoms of this condition are usually non-specific and consist of arrhythmia-related or heart failure-related manifestation; however, some peculiar diagnostic clues were detected, such as the T-wave inversion in the lateral leads, low QRS complexes voltages, mid-wall or epicardial fibrosis of the inferolateral wall of the left ventricle, and their presence should raise the suspicion of this condition. The risk stratification for sudden cardiac death is mandatory and several predictors were identified in recent years. However, the management of affected patients is often challenging due to the absence of specific prediction tools and therapies. This review aims to provide the current state of the art of PLN R14del cardiomyopathy, focusing on its pathophysiology, clinical manifestation, risk stratification for sudden cardiac death, and management.
A Promising Cobalt Catalyst for Hydrogen Production
Authors: Ulejczyk Bogdan , Jóźwik Paweł , Młotek Michał , Krawczyk Krzysztof
Published: March 2022

In this work, a metal cobalt catalyst was synthesized, and its activity in the hydrogen production process was tested. The substrates were water and ethanol. Activity tests were conducted at a temperature range of 350–600 °C, water to ethanol molar ratio of 3 to 5, and a feed flow of 0.4 to 1.2 mol/h. The catalyst had a specific surface area of 1.75 m2/g. The catalyst was most active at temperatures in the range of 500–600 °C. Under the most favorable conditions, the ethanol conversion was 97%, the hydrogen production efficiency was 4.9 mol (H2)/mol(ethanol), and coke production was very low (16 mg/h). Apart from hydrogen and coke, CO2, CH4, CO, and traces of C2H2 and C2H4 were formed.
Maintenance of Chronological Aging Features in Culture of Normal Human Dermal Fibroblasts from Old Donors
Authors: Rorteau Julie , Chevalier Fabien P. , Bonnet Sébastien , Barthélemy Théo , Lopez-Gaydon Amandine , Martin Lisa S. , Bechetoille Nicolas , Lamartine Jérôme
Published: March 2022

Chronological aging is defined as a time-dependent decline of tissue homeostasis which severely impacts skin. Understanding the mechanisms of skin aging is an active research area limited by the lack of relevant in vitro models. Being a component of aging, replicative or stress-induced senescence is repeatedly used to mimic skin aging in vitro, thus presenting only a partial view of the complexity of aging. Herein, we aimed to clarify whether primary normal human dermal fibroblasts retained age-related characteristics when cultured in 2D monolayer, and could be used as a relevant model for aging research. We compared three groups of fibroblasts isolated from different aged donors. We observed strongly decreased population doubling capacities, a reduced clonogenic ability, an impairment in extracellular matrix production together with modifications of respiratory metabolism with an increase in age. These disruptions were particularly marked when comparing fibroblasts isolated from old individuals (over 70 years old) to those isolated from young individuals (18–37 years old), while cells from middle-aged donors exhibited an intermediate profile. These alterations of cell features can be related to the signs of dermis aging, thus showing that cultured primary cells indeed retain some characteristics of the original tissue from which they were extracted.
Developmental Coordination Disorder before the Age of Three: A Longitudinal Retrospective Study in a Belgian Center for Developmental Disabilities
Authors: Vens Nina , Dewitte Griet , Van Waelvelde Hilde , Bar-On Lynn , De Roubaix Amy
Published: March 2022

This study aimed to explore the association between developmental coordination disorder (DCD) diagnosed after the age of three and both a standardized motor test—the Alberta Infant Motor Scale (AIMS)—and non-standardized observation of movement quality carried out before the age of three. Children at risk or with developmental concerns were studied retrospectively. Children were excluded in case of a diagnosis, excluding DCD, e.g., cerebral palsy, or IQ < 70. Of the 503 included children, 246 were diagnosed with (at-risk) DCD. Multivariate binary logistic regression revealed a significant association between DCD diagnosis after the age of three and male gender and with different aspects of poor movement quality in different age groups before the age three. Univariate analyses revealed an association between DCD diagnosis and the number of poor movement-quality descriptions at 0–6 months, 6–12 months, and 18 months–3 years but not with the AIMS scores. The MABC-2 scores after the age of three were significantly correlated with the number of poor movement-quality descriptions in age groups 0–6 months and 18 months–3 years and with the AIMS scores in age groups 6–12 months and 12–18 months. The results suggest that DCD can be associated with poor movement quality before the age of three.
Urology in Pediatrics
Authors: Cobellis Giovanni
Published: March 2022

Pediatric urology has been developed by many pediatric urologists and pediatric surgeons from all over the world [...]
The Changes in Visual Acuity Values of Japanese School Children during the COVID-19 Pandemic
Authors: Noi Shingo , Shikano Akiko , Imai Natsuko , Tamura Fumie , Tanaka Ryo , Kidokoro Tetsuhiro , Yoshinaga Mari
Published: March 2022

The coronavirus disease 2019 (COVID-19) pandemic may result in a greater decrease in visual acuity (VA) among Japanese children. Our study aimed to examine Japanese children’s VA during the pandemic. VA data were collected using standard eye tests during school health check-ups conducted in 2019 and 2020 on 5893 children, in seven public elementary schools and four public junior high schools in Tokyo, Saitama, Kanagawa, and Shizuoka. VA changes were statistically analyzed. The relationship between the survey year and poor VA yielded a significant regression coefficient for the surveyed years in elementary and junior high school students. The 2019 VA value and VA change from 2019 to 2020 demonstrated a significant regression coefficient in elementary school students with VAs of “B (0.7–0.9)” and “C (0.3–0.6)”, and junior high school students with VAs of “B”, “C”, and “D (<0.3)”. An analysis of the relationship between the survey year and eye laterality of VA yielded a significant regression coefficient in the surveyed years for elementary (OR, 1.516; 95% CI, 1.265–1.818) and junior high school students (OR, 1.423; 95% CI, 1.136–1.782). Lifestyle changes during the COVID-19 pandemic might have affected VA and eye laterality in Japanese children.
Study on Antifatigue Crack Growth Characteristics of Ball-End Milling Bionic Surface
Authors: Cui Youzheng , Wang Fengjuan , Hu Qingming , Zhang Wei
Published: March 2022

The surface morphology of parts has an important influence on service performance, such as wear resistance, fatigue resistance, and corrosion resistance. For example, the fatigue fracture resistance of the surface of the automobile cover mold directly determines the quality of the workpiece and the service life of the mold. In nature, the pit-shaped non-smooth form of the surface of certain organisms has good fatigue resistance. Using laser processing and other methods to prepare a pit-shaped bionic non-smooth surface on the surface of the part is an effective method to improve the fatigue resistance of the mold surface. Ball-end milling can form a regularly distributed pit-like surface morphology, and has the advantages of high processing efficiency, wide operating range, and low production cost compared with those of laser processing and preparation technology. It provides a new processing method for efficient milling preparation of bionic surfaces. In this paper, the morphology of the quadrilateral pits on the surface of the dung beetle is used as the prototype of the bionic design, and the mechanism of the antifatigue crack propagation characteristics of the quadrilateral pits of the bionic dung beetle is revealed and analyzed. The fatigue crack growth has a good retarding effect. At the same time, through numerical simulation and experimental research on the fatigue crack growth characteristics of the surface of the bionic pit, the results show that the source of fatigue cracks often starts inside the surface of the processed bionic pit, and the surface of the quadrilateral pit on the surface of the bionic dung beetle has good antifatigue crack growth characteristics.
Defect-Induced Luminescence Quenching of 4H-SiC Single Crystal Grown by PVT Method through a Control of Incorporated Impurity Concentration
Authors: Kim Seul-Ki , Jung Eun Young , Lee Myung-Hyun
Published: March 2022

The structural defect effect of impurities on silicon carbide (SiC) was studied to determine the luminescence properties with temperature-dependent photoluminescence (PL) measurements. Single 4H-SiC crystals were fabricated using three different 3C-SiC starting materials and the physical vapor transport method at a high temperature and 100 Pa in an argon atmosphere. The correlation between the impurity levels and the optical and fluorescent properties was confirmed using Raman spectroscopy, X-ray diffraction, inductively coupled plasma atomic emission spectroscopy (ICP-OES), UV-Vis-NIR spectrophotometry, and PL measurements. The PL intensity was observed in all three single 4H-SiC crystals, with the highest intensities at low temperatures. Two prominent PL emission peaks at 420 and 580 nm were observed at temperatures below 50 K. These emission peaks originated from the impurity concentration due to the incorporation of N, Al, and B in the single 4H-SiC crystals and were supported by ICP-OES. The emission peaks at 420 and 580 nm occurred due to donor–acceptor-pair recombination through the incorporated concentrations of nitrogen, boron, and aluminum in the single 4H-SiC crystals. The results of the present work provide evidence based on the low-temperature PL that the mechanism of PL emission in single 4H-SiC crystals is mainly related to the transitions due to defect concentration.
Rating the Dominance of Concepts in Semantic Taxonomies
Authors: Razis Gerasimos , Anagnostopoulos Ioannis , Zhou Hong
Published: March 2022

The descriptive concepts of “semantic” taxonomies are assigned to content items of the publishing domain for supporting a plethora of operations, mostly regarding the organization and discoverability of the content, as well as for recommendation tasks. However, either not all publishers rely on such structures, or in many cases employ their own proprietary taxonomies, thus the content is either difficult to be retrieved by the end users or stored in publisher-specific fragmented “data-silos”, respectively. To address these issues, the modular and scalable “Dominance Metric” methodology is proposed for rating the dominance and importance of concepts in semantic taxonomies. Our proposed metric is applied both on the vast multidisciplinary Microsoft Academic Graph Fields of Study taxonomy and the MeSH controlled vocabulary in order for their enhanced and refined versions to be produced. Moreover, we describe the cleansing process of the resulting taxonomy from Microsoft’s structure by deduplicating concepts and refining the hierarchical relations towards the increase of its representation quality. Our evaluation procedure provided valuable insights by showcasing that high volume, namely the number of publications a concept is assigned to, does not necessarily imply high influence, but the latter is also affected by the structural and topological properties of the individual entities.
The Performance Prediction of Electrical Discharge Machining of AISI D6 Tool Steel Using ANN and ANFIS Techniques: A Comparative Study
Authors: Pourasl Hamed H. , Javidani Mousa , Khojastehnezhad Vahid M. , Vatankhah Barenji Reza
Published: March 2022

AISI-D6 steel is widely used in the creation of dies and molds. In the present paper, first the electrical discharge machining (EDM) of the aforementioned material is performed with a testing plan of 32 trials. Then, artificial neural networks (ANN) and adaptive neuro-fuzzy inference system (ANFIS) were applied to predict the outputs. The effects of some significant operational parameters—specifically pulse on-time (Ton), pulse current (I), and voltage (V)—on the performance measures of EDM processes such as the material removal rate (MRR), tool wear ratio (TWR), and average surface roughness (Ra) are extracted. To lead the process operators, process plans (i.e., parameter–effect correlations) are created. The outcomes exposed the upper values of pulse on-time caused by higher amounts of MRR and Ra, and likewise lower volumes of TWR. Furthermore, growing the pulse current resulted in upper volumes of the material removal rate, tool wear ratio, and surface roughness. Besides, the higher input voltage resulted in a lower amount of MRR, TWR, and Ra. The estimation models developed by using experimental data recounting MRR, TWR, and Ra. The root means the square error was used to determine the error of training models. Furthermore, the estimated outcomes based on the models have been proven with an unseen validation set of experiments. They are found to be in decent agreement with the experimental issues. The investigation shows the powerful learning capability of an ANFIS model and its advantage in terms of modeling complex linear machining processes.
Rates of Smoking Cessation at 6 and 12 Months after a Clinical Tobacco Smoking Cessation Intervention in Head and Neck Cancer Patients in Northern Ontario, Canada
Authors: Santi Stacey A. , Conlon Michael S. C. , Meigs Margaret L. , Davidson Stacey M. , Mispel-Beyer Kyle , Saunders Deborah P.
Published: March 2022

Smoking during cancer treatment is associated with reduced treatment response and cancer recurrence in patients with tobacco-related cancers. The purpose of this study was to examine smoking characteristics in head and neck cancer patients (n = 503) with a history of smoking and examine the impact of an intensive clinical tobacco intervention to patients who were currently smoking. All participants completed an interviewer-administered questionnaire at study enrollment which examined smoking behaviours, motivations to quit, and strategies used to cessate smoking. Follow-up assessments were completed at 6- and 12-months which monitored whether patients had quit smoking, remained cessated, or continued to smoke since study recruitment. For those who were currently smoking (n = 186, 37.0%), an intensive clinical tobacco intervention that utilized the 3A’s—Ask, Advise, Arrange—and the Opt-Out approach was offered to assist with smoking cessation at their new patient visit and followed-up weekly during their head and neck radiation therapy for 7 weeks. At 6 months, 23.7% (n = 41) of those who were smoking successfully quit; 51.2% quit ‘cold turkey’ (defined as using no smoking cessation assistance, aids or pharmacotherapy to quit), while 34.9% used pharmacotherapy (varenicline (Champix)) to quit. On average, it took those who were smoking 1–5 attempts to quit, but once they quit they remained cessated for the duration of the study. Although the head and neck cancer patients in this study reported high levels of nicotine dependence, many were able to successfully cessate.
Monitoring a Bolted Vibrating Structure Using Multiple Acoustic Emission Sensors: A Benchmark
Authors: Ramasso Emmanuel , Verdin Benoît , Chevallier Gaël
Published: March 2022

The dataset presented in this work, called ORION-AE, is made of raw AE data streams collected by three different AE sensors and a laser vibrometer during five campaigns of measurements by varying the tightening conditions of two bolted plates submitted to harmonic vibration tests. With seven different operating conditions, this dataset was designed to challenge supervised and unsupervised machine/deep learning as well as signal processing methods which are developed for material characterization or structural health monitoring (SHM). One motivation of this work was to create a common benchmark for comparing data-driven methods dedicated to AE data interpretation. The dataset is made of time series collected during an experiment designed to reproduce the loosening phenomenon observed in aeronautics, automotive, or civil engineering structures where parts are assembled together by means of bolted joints. Monitoring loosening in jointed structures during operation remains challenging because contact and friction in bolted joints induce a nonlinear stochastic behavior.
Development of Amyloid PET Analysis Pipeline Using Deep Learning-Based Brain MRI Segmentation—A Comparative Validation Study
Authors: Lee Jiyeon , Ha Seunggyun , Kim Regina E. Y. , Lee Minho , Kim Donghyeon , Lim Hyun Kook
Published: March 2022

Amyloid positron emission tomography (PET) scan is clinically essential for the non-invasive assessment of the presence and spatial distribution of amyloid-beta deposition in subjects with cognitive impairment suspected to have been a result of Alzheimer’s disease. Quantitative assessment can enhance the interpretation reliability of PET scan; however, its clinical application has been limited due to the complexity of preprocessing. This study introduces a novel deep-learning-based approach for SUVR quantification that simplifies the preprocessing step and significantly reduces the analysis time. Using two heterogeneous amyloid ligands, our proposed method successfully distinguished standardized uptake value ratio (SUVR) between amyloidosis-positive and negative groups. The proposed method’s intra-class correlation coefficients were 0.97 and 0.99 against PETSurfer and PMOD, respectively. The difference of global SUVRs between the proposed method and PETSurfer or PMOD were 0.04 and −0.02, which are clinically acceptable. The AUC-ROC exceeded 0.95 for three tools in the amyloid positive assessment. Moreover, the proposed method had the fastest processing time and had a low registration failure rate (1%). In conclusion, our proposed method calculates SUVR that is consistent with PETSurfer and PMOD, and has advantages of fast processing time and low registration failure rate. Therefore, PET quantification provided by our proposed method can be used in clinical practice.
Control Strategy of Flywheel Energy Storage System Based on Primary Frequency Modulation of Wind Power
Authors: Jia Yu , Wu Zhenkui , Zhang Jihong , Yang Peihong , Zhang Zilei
Published: March 2022

As a form of energy storage with high power and efficiency, a flywheel energy storage system performs well in the primary frequency modulation of a power grid. In this study, a three-phase permanent magnet synchronous motor was used as the drive motor of the system, and a simulation study on the control strategy of a flywheel energy storage system was conducted based on the primary frequency modulation of wind power. The speed and current double closed-loop control strategy was used in the system start-up phase, and the power and current double-closed-loop control strategy were used in the power compensation phase. The model reference adaptive control was used to accurately estimate the speed and position of the rotor. The system compensates for the wind power output by using a wind turbine in real-time and conducting simulation experiments to verify the feasibility of the charge and discharge control strategy. At the same time, it can be verified that the flywheel energy storage system has a beneficial effect on wind power frequency modulation.
Volume Transport by a 3D Quasigeostrophic Heton
Authors: Sivakumar Adhithiya , Weiss Jeffrey B.
Published: March 2022

Oceanic flows self-organize into coherent vortices, which strongly influence their transport and mixing properties. Counter-rotating vortex pairs can travel long distances and carry trapped fluid as they move. These structures are often modeled as hetons, viz. counter-rotating quasigeostrophic point vortex pairs with equal circulations. Here, we investigate the structure of the transport induced by a single three-dimensional heton. The transport is determined by the Hamiltonian structure of the velocity field induced by the heton’s component vortices. The dynamics display a sequence of bifurcations as one moves through the heton-induced velocity field in height. These bifurcations create and destroy unstable fixed points whose associated invariant manifolds bound the trapped volume. Heton configurations fall into three categories. Vertically aligned hetons, which are parallel to the vertical axis and have zero horizontal separation, do not move and do not transport fluid. Horizontally aligned hetons, which lie on the horizontal plane and have zero vertical separation, have a single parameter, the horizontal vortex half-separation Y, and simple scaling shows the dimensional trapped volume scales as Y3. Tilted hetons are described by two parameters, Y and the vertical vortex half-separation Z, rendering the scaling analysis more complex. A scaling theory is developed for the trapped volume of tilted hetons, showing that it scales as Z4/Y for large Z. Numerical calculations illustrate the structure of the trapped volume and verify the scaling theory.
Fate of Bioactive Compounds during Lactic Acid Fermentation of Fruits and Vegetables
Authors: Paramithiotis Spiros , Das Gitishree , Shin Han-Seung , Patra Jayanta Kumar
Published: March 2022

Consumption of lactic acid fermented fruits and vegetables has been correlated with a series of health benefits. Some of them have been attributed to the probiotic potential of lactic acid microbiota, while others to its metabolic potential and the production of bioactive compounds. The factors that affect the latter have been in the epicenter of intensive research over the last decade. The production of bioactive peptides, vitamins (especially of the B-complex), gamma-aminobutyric acid, as well as phenolic and organosulfur compounds during lactic acid fermentation of fruits and vegetables has attracted specific attention. On the other hand, the production of biogenic amines has also been intensively studied due to the adverse health effects caused by their consumption. The data that are currently available indicate that the production of these compounds is a strain-dependent characteristic that may also be affected by the raw materials used as well as the fermentation conditions. The aim of the present review paper is to collect all data referring to the production of the aforementioned compounds and to present and discuss them in a concise and comprehensive way.
Sensory Capacities and Eating Behavior: Intriguing Results from a Large Cohort of Italian Individuals
Authors: Concas Maria Pina , Morgan Anna , Tesolin Paola , Santin Aurora , Girotto Giorgia , Gasparini Paolo
Published: March 2022

Eating behavior (EB) is a complex system influenced by many factors, but an undisputed role is played by the senses. In this work, we examined the effect of the sensory capacities on EB in 1152 Italian adult individuals. After administering a questionnaire on EB and assessing sensory performance through standard audiometric, olfactory, and taste tests, the prevalence of reduced sensory capacities (RSCs) and the correlation with selected risk factors were calculated. Regression models, structural equation modelling, and conditional recursive partitioning were used to investigate the relationship between variables. Around 70% of the subjects show reduced capacities in at least one sense, with taste being the most prevalent (55.21%). Male sex, aging, and low educational level are risk factors for RSCs. The increased number of senses with reduced capacities is a predictor of diminished food adventurousness and lower liking for vegetables, fish, and alcoholic beverages, while reduced capacities (RCs) in taste is a predictor of lower liking for alcoholic beverages and sweets. Overall, in addition to providing an overall picture of RSCs in Italian samples, our study reveals the association of RSCs with EB variables. This finding could have a relevant role in influencing individuals’ dietary habits and, therefore, health status.
Improving the Flavor of Fermented Sausage by Increasing Its Bacterial Quality via Inoculation with Lactobacillus plantarum MSZ2 and Staphylococcus xylosus YCC3
Authors: Wang Ji , Hou Jinna , Zhang Xin , Hu Jingrong , Yu Zhihui , Zhu Yingchun
Published: March 2022

This research aims to investigate the effects of Staphylococcus xylosus YCC3 (Sx YCC3) and Lactobacillus plantarum MSZ2 (Lp MSZ2) on lipid hydrolysis and oxidation, the bacterial community’s composition, and the volatile flavor compounds in fermented sausage. The bacterial community was examined by plate counting and high-throughput sequencing. Differential flavor compounds in non-inoculated and inoculated sausages were identified by principal component analysis (PCA) and orthogonal partial least squares discrimination analysis (OPLS-DA). The results showed that the free fatty acid (FFA) content was increased after inoculating with Sx YCC3 or Lp MSZ2. The pH, peroxide value (POV), thiobarbituric acid reactive substances (TBARS) value, lipoxygenase activity, and the counts of Enterobacteriaceae were lower in the inoculated sausage than in the non-inoculated sausage. The bacterial inoculation enhanced the competitiveness of Staphylococcus and Lactobacillus and restricted the growth of unwanted bacteria. The OPLS-DA revealed that (Z)-hept-2-enal, (E)-2-octenal, 1-nonanal, octanal, and 1-octen-3-ol were common differential flavor compounds that were found in the inoculated sausages but were not found in the non-inoculated sausages. A positive correlation was observed between the differential flavor compounds and the relative abundance of Staphylococcus or Lactobacillus, or the FFA content. Our results indicated that inoculation with Sx YCC3 or Lp MSZ2 can improve fermented sausages’ flavor by enhancing their bacterial quality and increasing their FFA content.
Encapsulation of Lactobacillus gasseri: Characterization, Probiotic Survival, In Vitro Evaluation and Viability in Apple Juice
Authors: Varela-Pérez Abigail , Romero-Chapol Oscar O. , Castillo-Olmos Ana G. , García Hugo S. , Suárez-Quiroz Mirna L. , Singh Jaspreet , Figueroa-Hernández Claudia Y. , Viveros-Contreras Rubí , Cano-Sarmiento Cynthia
Published: March 2022

The development of functional foods containing probiotic bacteria has become increasingly relevant to improve and maintain health. However, this is often limited to dairy food matrices given the complexity involved in maintaining a stable system together with high microbial viability in matrices such as juices. The objective of this study was to develop and characterize sodium alginate capsules loaded with Lactobacillus gasseri ATCC® 19992 ™ (LG). Cell viability under in vitro gastrointestinal conditions and during storage in apple juice were evaluated. The capsules were prepared by ionic gelation and an emulsification process was performed as pretreatment using two homogenization methods: magnetic stirring (AM) and Ultraturrax® rotor-stator homogenizer (UT). Cell viability after encapsulation was similar in the two processes: 65%. At the end of the in vitro gastrointestinal evaluation, the non-encapsulated probiotic cells did not show any viability, while the AM system was able to retain 100% of its viability and the UT retained 79.14%. The morphology of the capsules consisted of a continuous and homogeneous surface. Cell viability of LG encapsulated in apple juice stored at 4 °C for 21 days was 77% for AM, 55.43% for UT, and 63.10% for free LG.
Global Exponential Stability of Fractional Order Complex-Valued Neural Networks with Leakage Delay and Mixed Time Varying Delays
Authors: Hymavathi M. , Muhiuddin G. , Syed Ali M. , Al-Amri Jehad F. , Gunasekaran Nallappan , Vadivel R.
Published: March 2022

This paper investigates the global exponential stability of fractional order complex-valued neural networks with leakage delay and mixed time varying delays. By constructing a proper Lyapunov-functional we established sufficient conditions to ensure global exponential stability of the fractional order complex-valued neural networks. The stability conditions are established in terms of linear matrix inequalities. Finally, two numerical examples are given to illustrate the effectiveness of the obtained results.
Follow-Up of Extended Shells around B[e] Stars
Authors: Liimets Tiina , Kraus Michaela , Moiseev Alexei , Duronea Nicolas , Cidale Lydia Sonia , Fariña Cecilia
Published: March 2022

B[e] stars are massive B type emission line stars in different evolutionary stages ranging from pre-main sequence to post-main sequence. Due to their mass loss and ejection events these objects deposit huge amounts of mass and energy into their environment and enrich it with chemically processed material, contributing significantly to the chemical and dynamical evolution of their host galaxies. However, the large-scale environments of these enigmatic objects have not attracted much attention. The first and so far only catalog reporting the detection of extended shells around a sample of B[e] stars was an Hα imaging survey carried out in the year 2001, and was limited to bright targets in the northern hemisphere. We have recently started a follow-up of those targets to detect possible evolution of their nebulae in the plane of the sky over a baseline of two decades. Furthermore, we extend our survey to southern targets and fainter northern ones to complement and complete our knowledge on large-scale ejecta surrounding B[e] stars. Besides imaging in Hα and selected nebular lines, we utilize long-slit and 3D spectral observations across the nebulae to derive their physical properties. We discovered pronounced nebula structures around 15 more objects, resulting in a total of 27 B[e] stars with a large-scale nebula. Here we present our (preliminary) results for three selected objects: the two massive supergiants MWC137 and MWC 314, and the unclassified B[e] star MWC 819.
Development of Flexible Plasticized Ion Conducting Polymer Blend Electrolytes Based on Polyvinyl Alcohol (PVA): Chitosan (CS) with High Ion Transport Parameters Close to Gel Based Electrolytes
Authors: Sadiq Niyaz M. , Aziz Shujahadeen B. , Kadir Mohd F. Z.
Published: March 2022

In the current study, flexible films of polyvinyl alcohol (PVA): chitosan (CS) solid polymer blend electrolytes (PBEs) with high ion transport property close enough to gel based electrolytes were prepared with the aid of casting methodology. Glycerol (GL) as a plasticizer and sodium bromide (NaBr) as an ionic source provider are added to PBEs. The flexible films have been examined for their structural and electrical properties. The GL content changed the brittle and solid behavior of the films to a soft manner. X-ray diffraction (XRD) and Fourier transform infrared (FTIR) methods were used to examine the structural behavior of the electrolyte films. X-ray diffraction investigation revealed that the crystalline character of PVA:CS:NaBr declined with increasing GL concentration. The FTIR investigation hypothesized the interaction between polymer mix salt systems and added plasticizer. Infrared (FTIR) band shifts and fluctuations in intensity have been found. The ion transport characteristics such as mobility, carrier density, and diffusion were successfully calculated using the experimental impedance data that had been fitted with EEC components and dielectric parameters. CS:PVA at ambient temperature has the highest ionic conductivity of 3.8 × 10 S/cm for 35 wt.% of NaBr loaded with 55 wt.% of GL. The high ionic conductivity and improved transport properties revealed the suitableness of the films for energy storage device applications. The dielectric constant and dielectric loss were higher at lower frequencies. The relaxation nature of the samples was investigated using loss tangent and electric modulus plots. The peak detected in the spectra of tanδ and M” plots and the distribution of data points are asymmetric besides the peak positions. The movements of ions are not free from the polymer chain dynamics due to viscoelastic relaxation being dominant. The distorted arcs in the Argand plot have confirmed the viscoelastic relaxation in all the prepared films.