bluuebunny/crossref_metadata_2025 huggingface dataset:
Measurement of sustainable attitudes: a scale for business students
Authors: Prialé María Angela , Vera Ruiz Angela , Espinosa Agustin , Kamiche Zegarra Joanna Noelia , Yepes López Gustavo Adolfo , Darmohraj Adrián Marcelo , Flores Venturi Carlos Ivan
Published: May 2024

Purpose

This study aims to present the development and validation of a scale to measure the attitudes of Latin American business students toward sustainable management practices in the economic, social and environmental dimensions.

Design/methodology/approach

Using a nonprobabilistic sample, the appreciation for sustainable practices in students (ASP-S) scale was administered to a total of 653 undergraduate and graduate business students in Argentina, Colombia, Mexico and Peru. A range of psychometric validity (construct, convergent and discriminant) and reliability criteria were applied.

Findings

Construct, convergent and discriminant validity was obtained from the ASP-S scale across all samples. During the internal validation process, two factors were found: systemic consciousness (ten items) and sustainable business leadership (nine items), both of which obtained acceptable reliability indices. The resulting structure is equivalent in all four countries.

Originality/value

The instrument can be applied by educators and learning assurance areas to diagnose and measure the effectiveness of pedagogical strategies used in sustainability courses taught at Latin American business schools. As a result, it has applications for curriculum design. As a valid and reliable instrument set in the context of regional business praxis, it can promote an understanding of sustainable behaviors and practices in future Latin American leaders.
Design and optimization of lower limb exoskeleton based on multi-axis knee joint
Authors: Yun Jintian , Zhang Deqiang , Cui Weisheng , Li Shuai , Miao Guan
Published: May 2024

Purpose

The purpose of this paper is to improve the problem of kinematics incompatibility of human–exoskeleton in the existing rigid lower-limb exoskeleton (LLE).

Design/methodology/approach

In this paper, following an introduction, the motion characteristics of the human knee joint and the design method of the exoskeleton were introduced. A kinematics model of the LLE based on cross-four-bar linkage was obtained. The structural parameters of the LLE mechanism were optimized by the particle swarm optimization algorithm. The predefined trajectories used in the optimization process were derived from the ankle joint, not the instantaneous center of rotation of the knee joint. Finally, the motion deviation of the optimization result was simulated, and the human–exoskeleton coordination experiment was designed to compare with the traditional single-axis knee joint in terms of comfort and coordination.

Findings

The lower limb exoskeleton mechanism obtained in this paper has a good tracking effect on human movement and has been improved in terms of comfort and coordination compared with the traditional single-axis knee joint.

Originality/value

The customized exoskeleton design method introduced in this paper is relatively simple, and the obtained exoskeleton has better movement coordination than the traditional exoskeleton. It can provide a reference for the design of lower limb exoskeleton and lower limb orthosis.
Target similarity and gender difference: Effects of servant leadership on supervisory commitment and supervisory citizenship behavior
Authors: Nguyen Phuoc Hong , Nguyen Long Thanh , Nguyen Linh Tran Cam
Published: May 2024

Purpose

This study applies the target similarity model to examine the effects of servant leadership on supervisor commitment and supervisor citizenship behavior. The mediating role of supervisory commitment is explored to determine the relationship between servant leadership and supervisor citizenship behavior. The difference in supervisor gender is examined in the linkage between servant leadership and supervisory commitment.

Design/methodology/approach

The data were collected through a survey of 478 salespeople in the retail industry. Structural equation modeling (SEM) techniques were used to verify the hypotheses of this study.

Findings

The findings showed significant support for the direct and indirect effects of servant leadership on supervisor commitment and supervisor citizenship behavior. Furthermore, the positive relationship between servant leadership and supervisory commitment was stronger among female supervisors than male supervisors.

Originality/value

Due to the scarcity of studies conducted on the linkages of servant leadership, supervisory commitment and supervisory citizenship behavior, this study theoretically and empirically contributes to the leadership literature as it is the first study to investigate these direct and indirect relationships. Similarly, this study examined gender differences in servant leadership to fill the gap in the research field.
Do women have a say? A moderated mediation model's influence on the leverage policy toward corporate sustainable growth
Authors: Lestari Rohmini Indah , Indarto Indarto , Budiati Yuli
Published: May 2024

Purpose

Examining the role of women on board (WoB) toward corporate sustainable growth (CSG) through leverage policy (LP). This research also investigates the interaction effect of WoB and LP on improving CSG.

Design/methodology/approach

This study uses a moderated mediation model to examine the impact of WoB on CSG, mediated by LP. Data from 48 KEHATI IDX ESG Sector Leaders Index companies observed from 2015 to 2021 were analyzed using the structural equation model partial least square (SEM-PLS) Warp.PLS 8.0. The research applies instrumental variables (IV) to test and control endogeneity due to nonrandom sample selection.

Findings

We found evidence that LP acts as a full mediator between the presence of WoB and CSG. The presence of WoB plays a moderate role by slightly weakening the influence of LP on CSG. Furthermore, we obtained evidence showing that the relationship between WoB and CSG is J-curve-shaped, a nonlinear relationship related to critical mass. Where the WoB ratio is at least 8.35% or higher, it will increase CSG in companies that have implemented the concept of environment social governance (ESG) in Indonesia.

Originality/value

This model uses a moderated mediation model and J-curve analysis; there is an interaction between WoB and LP on different paths of the mediator to CSG. This model examines the role of WoB as a moderator of the effect of LP on CSG. A nonlinear J-curve test was conducted to determine the minimum level of WoB that can influence the increase of CSG.
The welfare impact of financial inclusion: a research agenda
Authors: Shen Yun , Agyekum Francis , Reddy Krishna , Wallace Damien
Published: May 2024

Purpose

This paper provides a systematic review of literature pertaining to the welfare impact of financial inclusion. We identify the 50 most influential publications in the field that have evolved into three distinct categories, each of which we critically review to identify the main contributions of this research area.

Design/methodology/approach

By conducting a state-of-the-art literature review, this paper identifies the most influential papers in the research fields on the welfare impact of financial inclusion. One caveat is that as newer publications generally have fewer citations, reviewing prior work can result in a misleading account of emerging trends and research directions. Manual assessment of publications after 2018 facilitates a discussion of important emerging research trends and their directions.

Findings

The three key research streams are identified as financial services and financial accessibility, financial capability, and financial literacy and household welfare. By assessing publications from 2018 to 2023, we also document four key emerging research trends: Fintech and digital financial inclusion, sustainability and climate change, growth, poverty, income inequality, financial stability, and Entrepreneurship. Drawing on these emerging trends, we highlight the opportunities for future research.

Research limitations/implications

Keyword searches have limitations as some papers might be overlooked if they do not match the specific search criteria, despite their relation and significance to the overall topic of the welfare impact of financial inclusion. To address this issue, we have expanded this review by incorporating more literature from other databases, such as the Scopus database which may alleviate this issue.

Practical implications

The three key research streams contribute to a comprehensive understanding of the welfare impact of financial inclusion. The emerging trends integrate existing knowledge and leave the chance for innovative research to expand the research frontier.

Originality/value

This paper fulfils the systematic literature review streams in the welfare impact of financial inclusion and provides fruitful opportunities for future research.
Navigating change: an exploration of socio-epistemic process of extending Wikidata ontology with new properties
Authors: Roszkowski Marcin
Published: May 2024

Purpose

The paper addresses the issue of change in Wikidata ontology by exposing the role of the socio-epistemic processes that take place inside the infrastructure. The subject of the study was the process of extending the Wikidata ontology with a new property as an example of the interplay between the social and technical components of the Wikidata infrastructure.

Design/methodology/approach

In this study, an interpretative approach to the evolution of the Wikidata ontology was used. The interpretation framework was a process-centric approach to changes in the Wikidata ontology. The extension of the Wikidata ontology with a new property was considered a socio-epistemic process where multiple agents interact for epistemic purposes. The decomposition of this process into three stages (initiation, knowledge work and closure) allowed us to reveal the role of the institutional structure of Wikidata in the evolution of its ontology.

Findings

This study has shown that the modification of the Wikidata ontology is an institutionalized process where community-accepted regulations and practices must be applied. These regulations come from the institutional structure of the Wikidata community, which sets the normative patterns for both the process and social roles and responsibilities of the involved agents.

Originality/value

The results of this study enhance our understanding of the evolution of the collaboratively developed Wikidata ontology by exposing the role of socio-epistemic processes, division of labor and normative patterns.
Implications of HR managers' green attitude: a study of Indian hospitality sector
Authors: Mekoth Nandakumar , Prabhudesai Rohit , Tari Sandesh
Published: May 2024

Purpose

The paper examines the influence of green attitude of HR managers on the other key HRM variables in an organizational context. Specifically, the objective of the paper was to determine if HR managers’ green attitude influences the green behavior of employees in an organization, while accounting for the mediating and moderating effect of contingent variables.

Design/methodology/approach

Data were gathered from 175 human resources managers of Indian hotels using a structured instrument and subjected to partial least squares-structural equation modeling (PLS-SEM) analysis, using SmartPLS 3.0 software.

Findings

While the green attitude of human resource managers was found to positively influence the green behavior of employees, it was observed that the extent of green rewards played a mediating role in the relationship. Top management support was found to moderate the relationship between green attitude of human resource managers and green human resource management practices.

Practical implications

The study identifies how green behavior of employees can be improved by focusing primarily on the green attitude of HR managers. Thus, recruiting HR managers with high green orientation, contingent on the exogenous factors mentioned in the study being considered, will result in greater pro-environment employee behavior.

Originality/value

Our unique contribution was viewing greening practices in the organization through the HR managers’ lens, who are critical in implementing green practices in an organization, thus providing novel insights compared to earlier studies in the field.
Representing the experiences of charity peer leaders facilitating well-being interventions to their peers using a constructivist grounded theory methodology
Authors: Burns Jenny
Published: May 2024

Purpose

This study aims to generate theory that represented charity peer leader experiences, facilitating well-being interventions to two specific groups of people: new mothers and refugees.

Design/methodology/approach

Part 1 of this study used in-depth interviews (n = 8) and phone calls with experienced mothers (called “peer leaders”) who had facilitated well-being interventions to new mothers. These interviews were analysed using Constructivist Grounded Theory (CGT) (Charmaz, 2014) generating a theory. Following a systematic literature review using the theory categories as search terms, a training approach was devised: The Modelled Training Approach (MTA). Refugees (n = 16) were trained to facilitate another well-being intervention using the MTA followed by a further set of interviews (n = 6). These interviews were analysed using CGT.

Findings

A theory was generated representing the “journey” the peer leaders took: their lived experience triggered empathic feelings towards their peers, which motivated them to build a rapport where they gave hope. As a result, the peer leaders felt rewarded.

Originality/value

The literature search did not find any studies looking at the experiences of peer leaders in the above settings. The theory generated could support mental health peer work offsetting statutory health costs.
Disrupting human resource management with people analytics: a study of applications, value, enablers and barriers in Italy
Authors: Di Lauro Stefano , Tursunbayeva Aizhan , Antonelli Gilda , Moschera Luigi
Published: May 2024

Purpose

This research aims to explore whether or how organizations adopt people analytics (PA), its value and potential socio-technical factors that can enable or hinder PA projects by disrupting and reshaping human resource management. We do this by focusing on the Italian context.

Design/methodology/approach

We conduct a scoping review of data collected between 2018 and 2022 via Google Alerts (GA), a content change detection and notification service that is gaining popularity in scholarly research.

Findings

Our findings suggest that the diffusion of PA applications in Italy, especially those of a descriptive nature, is growing. Most of the existing PA applications are positioned in a positive technocratic light, envisioning the value of PA for both employees and organizations. The value for the latter appears to be direct, while the value for employees is realized through organizational initiatives. The findings also suggest that while enablers can vary between PA application types, the barriers, especially technological and environmental, are generic for both descriptive and predictive/prescriptive PA applications.

Originality/value

Theoretically, we propose a framework for analyzing PA applications, their values, enablers and barriers. Methodologically, we present and describe in detail a novel approach, drawing on GA that can be used to study PA in specific contexts. Practically, our study serves as a helpful point of reference for managers planning or implementing PA in Italy, for benchmarking PA in Italy over time and for comparative international studies.
Navigating AACSB accreditation with strategic leadership and change management: a systematic literature review
Authors: Prastiwi Irene Budi , Tukiran Martinus
Published: May 2024

Purpose

This study aims to identify the strategic leadership and change management used to obtain the Association to Advance Collegiate Schools of Business (AACSB) accreditations as well as the research development on AACSB in the past decade.

Design/methodology/approach

This study used a systematic literature review following Petticrew and Roberts’ study. The articles were limited to empirical studies published from 2013 to 2022, taken from the Dimensions AI database.

Findings

The findings suggested that two leadership styles were used to obtain AACSB accreditation: dominance-oriented transformational and financial leadership, alongside three traits of academic leaders: commitment, engagement and encouragement. Additionally, three change management models/processes were found in the articles: teaching evaluation framework, temporary isomorphism and authenticity. Finally, they discovered that the object of the studies on AACSB accreditation had been narrowed down from the organizational level to smaller objects consisting of schools’ identity, teaching, learning and business schools’ key players.

Research limitations/implications

As this study only used Dimensions AI, potential articles related to the topic outside the database could not be obtained. Thus, it limits the scope of the findings of this paper.

Practical implications

This study informs academic leaders in business schools about the role of strategic leadership and change management in obtaining AACSB accreditation.

Originality/value

Through a systematic scoping review, this study presented a decade of research development on AACSB in addition to the strategic leadership and change management needed to obtain it.
Boardroom blind spots: why HR exclusion puts corporate reputations at risk
Authors: McCarron Anna
Published: May 2024

Purpose

This study aims to explore the ramifications of a lack of human resources (HR) representation in corporate boardrooms.

Design/methodology/approach

The author draws upon her personal and professional experience as a director of human resources and as a board member for a corporation.

Findings

There is a fundamental misunderstanding of the strategic value that HR brings to the table. To thrive in the modern business environment, organisations must acknowledge this strategic value and actively involve HR professionals in high-level decision-making processes.

Originality/value

This study makes a strong and compelling case for HR’s involvement in high-level decision-making in the boardroom.
Restructuring UK government at the Centre—Why the IfG Commission's Naïve Plan will not Work
Authors: Dunleavy Patrick
Published: May 2024

An Institute for Government (IfG) report on ‘government at the centre’ recommends creating new, rationalist policy machinery (including an inner cabinet) to manage the UK government's four‐year policy programmes—faithfully following how the Cameron‐Clegg coalition operated in 2010–15. That government's disastrous example shows how politically naïve this plan would be. This article draws out its complete infeasibility in late 2024 conditions. The IfG also proposes setting up a new Department for the Civil Service headed by a powerful minister as a counterweight to the Treasury (criticised only for being ‘too good’ and hence over‐dominant). Instead, this article sets out the case for a new and strong Department for Finance, Procurement and Productivity to take responsibility for spending control and other key public management roles, where the Treasury resource management has conspicuously failed in the last decade.
The Legal Landscape for Opioid Treatment Agreements
Authors: SVIRSKY LARISA , HOWARD DANA , FRIED MARTIN , RICHARDS NATHAN , THOMAS NICOLE , ZETTLER PATRICIA J.
Published: May 2024

Policy Points

Opioid treatment agreements (OTAs) are controversial because of the lack of evidence that their use reduces opioid‐related harms and the potential risks they pose of stigmatizing patients and undermining the clinician–patient relationship.

Even so, their use is now required in most jurisdictions, and their use is influencing the outcomes of civil and criminal lawsuits.

More research is needed to evaluate how OTAs are implemented given existing requirements. If additional research does not resolve the current level of uncertainty regarding OTA benefits, then policymakers in jurisdictions where they are required should consider eliminating OTA mandates or providing flexibility in the legal requirements to make room for clinicians and health care institutions to implement best practices.

Context

Opioid treatment agreements (OTAs) are documents that clinicians present to patients when prescribing opioids that describe the risks of opioids and specify requirements that patients must meet to receive their medication. Notwithstanding a lack of evidence that OTAs effectively mitigate opioids’ risks, professional organizations recommend that they be implemented, and jurisdictions increasingly require them. We sought to identify the jurisdictions that require OTAs, how OTAs might affect the outcomes of lawsuits that arise when things go wrong, and instances in which the law permits flexibility for clinicians and health care institutions to adopt best practices.

Methods

We surveyed the laws and regulations of all 50 states and the District of Columbia to identify which jurisdictions require the use of OTAs, the circumstances in which OTA use is mandatory, and the terms OTAs must include (if any). We also surveyed criminal and civil judicial decisions in which OTAs were discussed as evidence on which a court relied to make its decision to determine how OTA use influences litigation outcomes.

Findings

Results show that a slight majority (27) of jurisdictions now require OTAs. With one exception, the jurisdictions’ requirements for OTA use are triggered at least in part by long‐term prescribing. There is otherwise substantial variation and flexibility within OTA requirements. Results also show that even in jurisdictions where OTA use is not required by statute or regulation, OTA use can inform courts’ reasoning in lawsuits involving patients or clinicians. Sometimes, but not always, OTA use legally protects clinicians from liability.

Conclusions

Our results show that OTA use is entwined with legal obligations in various ways. Clinicians and health care institutions should identify ways for OTAs to enhance clinician–patient relationships and patient care within the bounds of relevant legal requirements and risks.
The Personal and The Transpersonal Psyche: Human Suffering, the Archetypes and the Clinical Encounter
Authors: Phillips Max
Published: May 2024

While Jung’s notion of archetypes has had far‐reaching universal appeal and significance, it remains less obvious how these ideas might benefit the analytic patient. In particular, the therapist and/or patient may struggle to hold the tension between the latter’s personal neuroses and how transpersonal/archetypal elements inform his/her experience. While Jung strove to develop a treatment that dealt primarily with the archetypal/objective psyche, the personal psyche is arguably the medium through which the archetypes are experienced. I contend that the “discipline” of Jungian analysis evolved from a transposition of Jung’s ideas around transpersonal, philosophical and religious themes (borne out of his own self‐analysis), into a two‐person psychotherapeutic process. Jung provides little description of his clinical encounters and the way in which he conducted his analyses leaving an uncertainty that has likely contributed to the divergence of approaches practised today by analytical psychologists. This article considers the implication of these divergences for contemporary Jungian practice and proposes a way of working in the Jungian spirit that maintains a connection to the symbolic realm while at the same time remaining focused on the complexities of personal and relational dynamics.
The special adaptation to hypoxia facilitated the expansion of the Asian house rat (Rattus tanezumi) into Tibet but not other Rattus species
Authors: CAO Ruidong , ZHANG Mingyu , CHEN Yi , HOU Guanmei , LIU Quansheng , ZHANG Jianxu , ZHANG Yaohua
Published: May 2024

Rattus species are thought to live only at altitudes less than 2500 m, but the Asian house rat (R. tanezumi) (RT) has recently expanded to altitudes greater than 3500 m in China. Other Rattus species, especially brown rats (R. norvegicus) (RN), still reach only low altitudes on the Tibetan Plateau. Comparative genomics revealed the positive selection of hypoxia‐inducible transcription factors 1 and 2 (HIFs) in RT, with the rapid evolution of HIF pathway genes in RT and Mus musculus (MM) but not RN or R. rattus. Population genomics revealed that genes associated with energy metabolism and oxygen transport were positively selected in RT compared with the other four Rattus species, and two specific substitutions (arginine 31 serine and leucine 33 methionine) were identified in the hemoglobin subunit beta (HBB) in RT. The above results suggested that RT possesses unique genetic adaptations to hypoxia, which was further confirmed by behavioral experiments on RT and RN. Normobaric hypoxia significantly reduced locomotion in RN but not in RT. Moreover, through intraspecific transcriptome analysis, the expression of Hbb and genes related to angiogenesis, oxygen transport, and glycolysis was upregulated, and the expression of genes associated with immunological functions in the liver, lungs, and/or sperm was downregulated in RT compared to those in RN. Interspecific transcriptome analysis further revealed that HIF‐1α plays a role in modulating the hypoxic adaptation of RT rather than RN. Our work provides genomic, behavioral, and physiological insights into why RT, but not other Rattus species, could invade the Tibetan Plateau.
Genomics‐informed captive breeding can reduce inbreeding depression and the genetic load in zoo populations
Authors: Speak Samuel A. , Birley Thomas , Bortoluzzi Chiara , Clark Matthew D. , Percival‐Alwyn Lawrence , Morales Hernán E. , van Oosterhout Cock
Published: May 2024

Zoo populations of threatened species are a valuable resource for the restoration of wild populations. However, their small effective population size poses a risk to long‐term viability, especially in species with high genetic load. Recent bioinformatic developments can identify harmful genetic variants in genome data. Here, we advance this approach, analysing the genetic load in the threatened pink pigeon (Nesoenas mayeri). We lifted the mutation‐impact scores that had been calculated for the chicken (Gallus gallus) to estimate the genetic load in six pink pigeons. Additionally, we perform in silico crossings to predict the genetic load and realized load of potential offspring. We thus identify the optimal mate pairs that are theoretically expected to produce offspring with the least inbreeding depression. We use computer simulations to show how genomics‐informed conservation can reduce the genetic load whilst reducing the loss of genome‐wide diversity. Genomics‐informed management is likely to become instrumental in maintaining the long‐term viability of zoo populations.
Physical restraint intervention in the intensive care unit: An observational pilot study
Authors: Hakverdioğlu Yönt Gülendam , Bulut Süreyya , Müller‐Staub Maria , Kizilirmak Hüseyin
Published: May 2024

Purpose

Physical restraint (PR) is applied for patients’ safety and to prevent the removal of inserted devices. No matter how well applied, PR causes undesired effects and discomfort to patients. Because PR‐Guidelines are not yet implemented in Turkey, an observational study was performed to get baseline data on the type and number of PR‐activities and on patients’ complications in intensive care unit (ICU) patients.

Methods

An observational pilot study was conducted in anesthesia and reanimation adult ICUs in a midsized general hospital in Turkey. Included were 31 patients and two data collection tools: a basic form (patient demographics, medical information, and complications) and a PR observation guide on nurses’ PR‐activities. Descriptive statistics (frequencies, percentages, and mean and standard deviation) were used for data evaluation.

Findings

Most patients (61.3%) were male, and 74.2% were aged 60–79 years. Almost a third was unconscious (Glasgow Coma Scale <9) and at risk for falling. Of the total 33 activities of the Nursing Interventions Classification (NIC), 13 were never applied in 33% of patients. The most applied activity was “provide sufficient staff to assist with the safe application of physical restraining devices or manual restraints” (96.8%). Least applied were “explain inpatient and significant others the behaviors necessary for the termination of the intervention,” “Provide the dependent patient with a means of summoning help” (6.5%), and “Teach family the risks and benefits of restraint reduction” (3.2%). Overall, 58.1% of patients had PR complications.

Conclusions

For the first time, PR NIC activities were evaluated in a Turkish ICU. Findings show low performance of NIC activities and a high complication rate.

Implications for nursing practice

The findings provide the basis to implement a PR‐Guideline in Turkish ICUs to enhance patients’ safety and comfort.
Whole‐genome resequencing deciphers patterns of genetic diversity, phylogeny, and evolutionary dynamics in Kashmir cattle
Authors: Ahmed Zulfiqar , Xiang Weixuan , Wang Fuwen , Nawaz Mohsin , Kuthu Zulfiqar Hussan , Lei Chuzhao , Xu Dequan
Published: May 2024

Kashmir cattle, which were kept by local pastoralists for centuries, are exceptionally resilient and adaptive to harsh environments. Despite its significance, the genomic characteristics of this cattle breed remain elusive. This study utilized whole genome sequences of Kashmir cattle (n = 20; newly sequenced) alongside published whole genomes of 32 distinct breeds and seven core cattle populations (n = 135). The analysis identified ~25.87 million biallelic single nucleotide polymorphisms in Kashmir cattle, predominantly in intergenic and intron regions. Population structure analyses revealed distinct clustering patterns of Kashmir cattle with proximity to the South Asian, African and Chinese indicine cattle populations. Genetic diversity analysis of Kashmir cattle demonstrated lower inbreeding and greater nucleotide diversity than analyzed global breeds. Homozygosity runs indicated less consanguineous mating in Kashmir cattle compared with European taurine breeds. Furthermore, six selection sweep detection methods were used within Kashmir cattle and other cattle populations to identify genes associated with vital traits, including immunity (BOLA‐DQA5, BOLA‐DQB, TNFAIP8L, FCRL4, AOAH, HIF1AN, FBXL3, MPEG1, CDC40, etc.), reproduction (GOLGA4, BRWD1, OSBP2, LEO1 ADCY5, etc.), growth (ADPRHL1, NRG2, TCF12, TMOD4, GBP4, IGF2, RSPO3, SCD, etc.), milk composition (MRPS30 and CSF1) and high‐altitude adaptation (EDNRA, ITPR2, AGBL4 and SCG3). These findings provide essential genetic insights into the characteristics and establish the foundation for the scientific conservation and utilization of Kashmir cattle breed.
A Pacific community resilience framework: Exploring a holistic perspective through a strengths‐based approach and systems thinking
Authors: Gero Anna , Winterford Keren , Davila Federico
Published: May 2024

The impacts of climate change in the Pacific and worldwide have prompted researchers and practitioners to find ways to define, assess and support community resilience. This paper presents a community resilience framework to help meet this challenge. While traditional framings of resilience in scholarship are often based on deficit models that focus on vulnerability and gaps, this framework draws on strengths‐based principles and systems thinking approaches to support a holistic and integrated perspective of community resilience. Pacific community resilience literature underpins the framework, which values and prioritises diverse community insights to support locally defined pathways towards adaptation and resilience building. We offer examples of future application of the framework in a range of contexts such as research, programme design, strategic policy, programme implementation or evaluation.
Inclusive peer review: Reflections on an adapted citizens' jury with people with learning disabilities
Authors: Henderson Angela , Cassidy John , Croydon Abigail , Nind Melanie
Published: May 2024

Background

Inclusive research is widely accepted as an essential part of the process to democratise knowledge creation and dissemination. However, while peer review is an important part of academic publishing, the potential to include people with learning disabilities in this element of the research process has not previously been explored using a deliberative approach.

Methods

Accessibility adaptations were made to the citizens' jury approach enabling people with learning disabilities to participate. Sixteen adults with mild to moderate learning disabilities were recruited to participate in the adapted citizens' jury. Jury members took part in capacity‐building workshops to develop their knowledge of research and research processes. Six expert witnesses presented evidence to the citizens' jury and were questioned on aspects of inclusive research, representation, peer review and academic publishing processes. Facilitators supported citizens' jury members to reflect on the evidence presented and to develop recommendations for inclusive peer review.

Findings

The citizens' jury was an effective inclusive research approach in this case. Jurors made recommendations related to the question of inclusive peer review: inclusive reviews should be done by groups rather than individuals; the research under review must be in accessible formats and on relevant topics; reviewers need sufficient time to conduct reviews; and diverse groups of people with learning disabilities should be involved.

Conclusions

People with learning disabilities appreciate the importance of peer review but do not necessarily want to participate in it. This jury suggested creative approaches to disseminating, reviewing and engaging with research, including building more opportunities for dialogue between researchers and self‐advocates. The adapted citizens' jury was a novel and effective method of supporting deliberation on this topic but other approaches to including the views and experiences of those with more severe learning disabilities should be explored.
Neutrophil extracellular traps modulate chemotherapy efficacy and its adverse side effects
Authors: Mousset Alexandra , Albrengues Jean
Published: May 2024

Neutrophils, major regulator of innate immunity have recently emerged as key components of the tumor microenvironment. The role of neutrophils in cancer has been linked to their ability to form neutrophil extracellular traps (NETs), structures composed of decondensed DNA decorated with enzymes that are released into the extracellular space. Here, we discuss the pivotal roles of NETs, in influencing responses to chemotherapy and its severe adverse effect. Highlighting recent insights, we discuss the dual nature of NETs in the context of chemotherapy treatment, examining their potential to either counteract or enhance treatment outcomes. Strategic targeting of NETs emerges as a promising avenue for determining combination therapies that could help counteracting resistance or enhancing chemotherapy efficacy as well as limiting complications due to this type of treatment.
Comparison of feline and human immunodeficiency virus reverse transcriptase enzymes through chemical screening and computational analysis
Authors: Thammajong Phanicha , Aiebchun Thitinan , Boonyarattanakalin Kanokthip , Gleeson Duangkamol , Pobsuk Nattakarn , Hannongbua Supa , Choowongkomon Kiattawee , Gleeson M. Paul
Published: May 2024

Feline immunodeficiency virus (FIV) is a common infection found in domesticated and wild cats worldwide. Despite the wealth of therapeutic understanding of the disease in humans, considerably less information exists regarding the treatment of the disease in felines. Current treatment relies on drugs developed for the related human immunodeficiency virus (HIV) and includes compounds of the popular non‐nucleotide reverse transcriptase (NNRTI) class. This is despite FIV‐RT being only 67% similar to HIV‐1 RT at the enzyme level, increasing to 88% for the allosteric pocket targeted by NNRTIs. The goal of this project was to try to quantify how well the more extensive pharmacological knowledge available for human disease translates to felines. To this end we screened known NNRTIs and 10 diverse pyrimidine analogs identified virtually. We use this chemo‐centric probe approach to (a) assess the similarity between the two related RT targets based on the observed experimental inhibition values, (b) try to identify more potent inhibitors at FIV, and (c) gain a better appreciation of the structure–activity relationships (SAR). We found the correlation between IC50s at the two targets to be strong (r2 = 0.87) and identified compound 1 as the most potent inhibitor of FIV with IC50 of 0.030 μM ± 0.009. This compared to FIV IC50 values of 0.22 ± 0.17 μM, 0.040 ± 0.010 μM and >160 μM for known anti HIV‐1 RT drugs Efavirenz, Rilpivirine, and Nevirapine, respectively. This knowledge, along with an understanding of the structural origin that give rise to any differences could improve the way HIV drugs are repurposed for FIV.
Novel carbamodithioate regulates cellular hypoxia through chemical activation of prolyl hydroxylase‐2 for breast cancer chemoprevention
Authors: Rastogi Shubham , Ansari Mohd Nazam , Saeedan Abdulaziz S. , Yadav Sachin , Kumar Dinesh , Singh Sunil Kumar , Mukerjee Alok , Singh Manjari , Kaithwas Gaurav
Published: May 2024

Inhibition of prolylhydroxylase‐2 (PHD‐2) in both normoxic and hypoxic cells is a critical component of solid tumours. The present study aimed to identify small molecules with PHD‐2 activation potential. Virtually screening 4342 chemical compounds for structural similarity to R59949 and docking with PHD‐2. To find the best drug candidate, hits were assessed for drug likeliness, antihypoxic and antineoplastic potential. The selected drug candidate's PHD‐2 activation, cytotoxic and apoptotic potentials were assessed using 2‐oxoglutarate, MTT, AO/EtBr and JC‐1 staining. The drug candidate was also tested for its in‐vivo chemopreventive efficacy against DMBA‐induced mammary gland cancer alone and in combination with Tirapazamine (TPZ). Virtual screening and 2‐oxoglutarate assay showed BBAP‐6 as lead compound. BBAP‐6 exhibited cytotoxic and apoptotic activity against ER+ MCF‐7. In carmine staining and histology, BBAP‐6 alone or in combination with TPZ restored normal surface morphology of the mammary gland after DMBA produced malignant alterations. Immunoblotting revealed that BBAP‐6 reduced NF‐κB expression, activated PHD‐2 and induced intrinsic apoptotic pathway. Serum metabolomics conducted with 1H NMR confirmed that BBAP‐6 prevented HIF‐1α and NF‐κB‐induced metabolic changes in DMBA mammary gland cancer model. In a nutshell, it can be concluded that BBAP‐6 activates PHD‐2 and exhibits anticancer potential.
Mitigating invalid data bias in the estimation of sexual orientation disparities in a survey of youth in US and Canada
Authors: Delgado‐Ron Jorge Andrés , Jeyabalan Thiyaana , Watt Sarah , Salway Travis
Published: May 2024

The current commentary explored the applicability of the methods described in “Mitigating invalid and mischievous survey responses: A registered report examining risk disparities between heterosexual and lesbian, gay, bisexual, or questioning youth” by Dr. Joseph Cimpian and colleagues to explore sexual orientation disparities in preexisting data from a nonprobability sample. Understanding Affirming Communities, Relationships, and Networks was a study of mostly White (77.4%) 9674 sexual and gender‐minoritized youth aged 15–29 from the US and Canada. The influence of invalid data on the prevalence ratios of four health outcomes was assessed. The methods yielded similar effects to the original paper. The accuracy varied by outcome prevalence and was robust to misspecification of the model. Therefore, the applicability of this method to preexisting data seems feasible.
Exploring the effects of weighting against homoplasy in genealogies of palaeontological phylogenetic matrices
Authors: Ezcurra Martín D.
Published: May 2024

Although simulations have shown that implied weighting (IW) outperforms equal weighting (EW) in phylogenetic parsimony analyses, weighting against homoplasy lacks extensive usage in palaeontology. Iterative modifications of several phylogenetic matrices in the last decades resulted in extensive genealogies of datasets that allow the evaluation of differences in the stability of results for alternative character weighting methods directly on empirical data. Each generation was compared against the most recent generation in each genealogy because it is assumed that it is the most comprehensive (higher sampling), revised (fewer misscorings) and complete (lower amount of missing data) matrix of the genealogy. The analyses were conducted on six different genealogies under EW and IW and extended implied weighting (EIW) with a range of concavity constant values (k) between 3 and 30. Pairwise comparisons between trees were conducted using Robinson–Foulds distances normalized by the total number of groups, distortion coefficient, subtree pruning and regrafting moves, and the proportional sum of group dissimilarities. The results consistently show that IW and EIW produce results more similar to those of the last dataset than EW in the vast majority of genealogies and for all comparative measures. This is significant because almost all of these matrices were originally analysed only under EW. Implied weighting and EIW do not outperform each other unambiguously. Euclidean distances based on a principal components analysis of the comparative measures show that different ranges of k‐values retrieve the most similar results to the last generation in different genealogies. There is a significant positive linear correlation between the optimal k‐values and the number of terminals of the last generations. This could be employed to inform about the range of k‐values to be used in phylogenetic analyses based on matrix size but with the caveat that this emergent relationship still relies on a low sample size of genealogies.
Vibrations as a new tool for pest management – a review
Authors: Yanagisawa Ryuhei , Tatsuta Haruki , Sekine Takayuki , Oe Takaho , Mukai Hiromi , Uechi Nami , Koike Takuji , Onodera Ryuichi , Suwa Ryuichi , Takanashi Takuma
Published: May 2024

Sensory stimuli are essential for arthropod survival and reproduction. Given the widespread use of vibrational communication among diverse taxa, exploiting vibrational senses has great potential for successful pest management. In this review, we summarize our recent findings on vibration‐based pest management and future perspectives in the context of integrated pest management. We first examine the management of whiteflies – the tobacco whitefly, Bemisia tabaci (Gennadius) and the greenhouse whitefly, Trialeurodes vaporariorum (Westwood) (Hemiptera: Aleyrodidae) – in various facilities where tomatoes are cultivated. We then explore the recent application of vibration for the control of fungus gnats of the genus Neoempheria (Diptera: Mycetophilidae) infesting shiitake mushrooms. Finally, we discuss the control of the brown‐winged green stink bug, Plautia stali Scott (Hemiptera: Pentatomidae), a pest of fruit trees in Japan. Notably, our trials have demonstrated that vibrational treatments are profitable not only for reducing pest populations but also for indirect benefits such as increased crop yields or the enhancement of pest control effectiveness.
Rapid climate change increases diversity and homogenizes composition of coastal fish at high latitudes
Authors: Siwertsson Anna , Lindström Ulf , Aune Magnus , Berg Erik , Skarðhamar Jofrid , Varpe Øystein , Primicerio Raul
Published: May 2024

Rapid warming at high latitudes triggers poleward shifts of species' distributions that impact marine biodiversity. In the open sea, the documented redistributions of fish lead to a borealization of Arctic fauna. A climate‐driven borealization and increased species diversity at high latitudes are also expected in coastal fish communities, but they have not been previously documented on a large, biogeographic scale. Here, we investigate the impact of temperature change over the last 25 years on fish communities along the coast of Norway. The study area, spanning different ecoclimatic zones between 62° and 71° N, harbors over 200 species of boreal and Arctic fish. Several of these fish species are harvested by coastal and indigenous communities, influencing settlement geography and livelihood. The long‐term data on coastal water temperatures and fish species were obtained from monitoring stations and scientific surveys. Water temperature measured at three fixed sampling stations distributed along the coast show increased temperatures during the study period. The fish species distribution and abundance data were obtained from the annually standardized scientific bottom trawl survey program. Fish species richness, which was highest in the south, increased with warming first in the south and then, gradually, further north, eventually affecting biodiversity in the whole study area. Fish community composition showed a distinct latitudinal pattern early in the study, with Arctic fish species confined to the north and boreal species dominating the south. The poleward shifts eventually eroded this zoogeographic pattern, resulting in more boreal fish species in the north and an increased homogenization of species composition along the Norwegian coast. The climate‐driven reorganization of fish communities affects coastal ecosystems that are exposed to fisheries, aquaculture, and other rapidly expanding human activities, stressing the urgent need for a climate adaptation of integrated coastal management.
Head‐to‐head: Should Ki67 proliferation index be included in the formal classification of pulmonary neuroendocrine neoplasms?
Authors: Pelosi Giuseppe , Travis William D.
Published: May 2024

The reporting of lung neuroendocrine neoplasms (NENs) according to the 2021 World Health Organisation (WHO) is based on mitotic count per 2 mm2, necrosis assessment and a constellation of cytological and immunohistochemical details. Accordingly, typical carcinoid and atypical carcinoid are low‐ to intermediate‐grade neuroendocrine tumours (NETs), while large‐cell neuroendocrine carcinoma (NEC) and small‐cell lung carcinoma are high‐grade NECs. In small‐sized diagnostic material (cytology and biopsy), the noncommittal term of carcinoid tumour/NET not otherwise specified (NOS) and metastatic carcinoid NOS have been introduced with regard to primary and metastatic diagnostic settings, respectively. Ki‐67 antigen, a well‐known marker of cell proliferation, has been included in the WHO classification as a non‐essential but desirable criterion, especially to distinguish NETs from high‐grade NECs and to delineate the provisional category of carcinoid tumours/NETs with elevated mitotic counts (> 10 mitoses per mm2) and/or Ki‐67 proliferation index (≥ 30%). However, a wider use of this marker in the spectrum of lung NENs continues to be highly reported and debated, thus witnessing a never‐subsided attention. Therefore, the arguments for and against incorporating Ki‐67 in the classification and clinical practice of these neoplasms are discussed herein in detail.