bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiomics Applications in Primary Liver Cancer
Authors: Lee Seung Soo
Published: July 2023

Radiomics refers to a method for extracting quantitative features from images and analyzing them. Compared with classic visual image analysis, radiomics provides a more comprehensive and objective approach and is expected to provide additional information from images that cannot be achieved with visual image analysis. Radiomics has been investigated for its potential in predicting the prognosis and biologic behavior of primary liver cancers. Although radiomics offers some advantages, it has several limitations that need to be addressed before it can be used in clinical practice. In this review article, I will discuss radiomics features, the typical processes for radiomics analysis, representative research on radiomics applications in liver cancers, and the limitations of radiomics.
Diagnosing Hepatocellular Carcinoma Using Sonazoid Contrast-Enhanced Ultrasonography: 2023 Guidelines from the Korean Society of Radiology and the Korean Society of Abdominal Radiology
Authors: Jeong Woo Kyoung , Kang Hyo-Jin , Choi Sang Hyun , Park Mi-Suk , Yu Mi Hye , Kim Bohyun , You Myung-Won , Lim Sanghyeok , Cho Young Seo , Lee Min Woo , Hwang Jeong Ah , Lee Jae Young , Kim Jung Hoon , Joo Ijin , Bae Jae Seok , Kim So Yeon , Chung Yong Eun , Kim Dong Hwan , Lee Jeong Min
Published: July 2023

Sonazoid, a second-generation ultrasound contrast agent, was introduced for the diagnosis of hepatic nodules. To clarify the issues with Sonazoid contrast-enhanced ultrasonography for the diagnosis of hepatocellular carcinoma (HCC), the Korean Society of Radiology and Korean Society of Abdominal Radiology collaborated on the guidelines. The guidelines are de novo, evidence-based, and selected using an electronic voting system for consensus. These include imaging protocols, diagnostic criteria for HCC, diagnostic value for lesions that are inconclusive on other imaging results, differentiation from non-HCC malignancies, surveillance of HCC, and treatment response after locoregional and systemic treatment for HCC.
THE EFFICACY AND SAFETY OF MAGNESIUM SULPHATE FOR NEONATAL NEUROPROTECTION IN PATIENTS WITH IMMINENT PRETERM DELIVERIES: EXPERIENCE AT A TERTIARY CARE HOSPITAL
Authors: Mazhar Tayaba , Rauf Shahzad , Asma Ambareen  , Shahnaz Nadir
Published: July 2023

Objective
The study aimed to find the effect of 4 grams of intravenous bolus antenatal dose of magnesium Sulphate on maternal and neonatal outcomes in preterm births.
Material and Methods
In a one-year cross-sectional descriptive study,  patients with active preterm labor or those with planned preterm birth at 28-34 weeks of gestation were included. Antenatal magnesium Sulphate was administered as a 4gm IV loading dose over 30 minutes. The data was analyzed with SPSS (version 20), where mean ± standard deviation was used for numerical variables and frequency and percentages for categorical variables. The sample size was 88.  A P value <_0.05 is used as a threshold for statistical significance.
Results
The mean age of patients was 28.78 (± SD of 6.038) and the mean period of gestation remained 32.04 (±1.868). Similarly, the mean cervical dilatation at which magnesium Sulphate was given was 6.591 (±1.358), the mean baby’s weight was 1.655 (±0.508) kg, and the mean Apgar score at 5 minutes was recorded as 7.11 (±1.208). Regarding the period of gestation of the patients, 15 (17.04%) were at 28-30 weeks, 26 (29.54%) were at 30– 32 weeks and 47 (53.4%) were at 32– 34 weeks. Out of 88 patients, normal vaginal deliveries were conducted in 61 (69.38%) whereas, 27 (30.68%) patients had cesarean sections.
Neonatal seizures were observed in 3 (2.6%), intraventricular hemorrhage in 2 (1.754%), Periventricular leukomalacia (PVL) 1(0.877%), and neonatal mortality in 5 (4.38%).
Conclusion
Magnesium Sulphate is a safe drug that plays an important role in protecting immature brains. Four-gram bolus is a sufficient dose as compared with infusion, which requires additional human resources and risks attached to prolonged infusions.
Key Words: Magnesium Sulphate, Preterm Deliveries, Neonatal Neuroprotection, Intraventricular Hemorrhage
CHEMICAL ANALYSIS OF DIFFERENT BRANDS OF BOTTLED WATER WITH WORLD HEALTH ORGANIZATION (WHO) STANDARDS
Authors: Mustafa Adeela , Hasnain Azam  , Sarmad Ayaz Khan  , Hoor ul ain  , Faryal Gul  , Awais Muhammad , Inayatullah -
Published: July 2023

Abstract:

Objective: To assess the quality and compare different brands of bottled drinking water with WHO standards.

 Methods: This is a cross sectional descriptive study conducted in Peshawar, Pakistan in 2022. 14 brands of bottled water was selected randomly and two samples of each brand were analyzed for physiochemical parameters in the laboratory of Khyber medical college.

Results: In our results the physiochemical parameters such as colour, odor, taste, turbidity, chloride, nitrate, total solids, calcium and sulphate of all samples were found within the of WHO standards.

Conclusion: Our study concluded that the bottled drinking water of different brands available in Peshawar city is physiochemically fit for consumption as all the parameter tested were within the permissible limits of WHO.

Key words: Bottled water, Drinking water, WHO water quality standards, Physiochemical parameters
FREQUENCY OF HYPERURICEMIA IN TYPE 2 DIABETES MELLITUS PATIENTS WITH BMI >23 KG/M2- STUDY AT A TERTIARY CARE HOSPITAL
Authors: Noor Aqil , Kanwal Shaista , Malik Suleman Elahi , Ullah Zafran , Ghaffar Tahir , Usman Khalid
Published: July 2023

OBJECTIVE: To determine the frequency of hyperuricemia in type 2 diabetes mellitus (T2DM) patients with BMI >23 kg/m2
MATERIALS AND METHODS: This descriptive study was conducted from February 2020 to September 2021. All patients with Type 2 Diabetes Mellitus (T2DM )with body mass index (BMI) >23 kg/m2 were assessed for hyperuricemia through Roche Cobas 6000 series C501 in MTI Hayatabad Medical Complex’s laboratory.     
RESULTS: Total number of patients was 300, out of which 60 % were males. The studied population has a mean age of 59 (SD =±7) years, mean systolic blood pressure was 151 (SD = ±17) mmHg, mean duration of T2DM was 13 (SD = ±4) years, mean HbA1c was 10.9 (SD = ±2.5) %, mean BMI was 28.8 (SD = ±3.1) kg/m2 and mean serum uric acid was 5.7 (SD=±1.3) mg/dl. The overall prevalence of Hyperuricemia was 47% (36.7 % males and 62.5% females). Of those with hyperuricemia, 73 % were also found to have hypertension. Results showed that patients with hyperuricemia belonged to older age, and have higher Systolic blood pressure, raised BMI, and HbA1c. The mean differences were considered statistically significant with a p-value < 0.05 by using an independent sample t-test.
CONCLUSION: The current study demonstrated a higher prevalence of hyperuricemia in T2DM patients with BMI> 23 kg/m2. Patients with hyperuricemia had a higher mean HbA1c, higher mean BMI, and raised systolic component of blood pressure.
KEY WORDS: BMI, Hyperuricemia, Hypertension, Type 2 diabetes mellitus, HbA1c
HYPOMAGNESEMIA CAUSING VENTRICULAR TACHYCARDIA IN PATIENTS PRESENTING TO A CORONARY CARE UNIT
Authors: Khan Zahoor Ahmad , Khan Rahim Dil , Hussain Charagh , Nawaz Tariq , Hakeem Yasir , Ullah Hameed
Published: July 2023

OBJECTIVE: To determine the frequency of hypomagnesemia in patients with ventricular tachycardia.
Materials and Methods: It is a descriptive Cross-Sectional study conducted in the Department of Cardiology, MTI-HMC, Peshawar from 20 Sept 2020 to 20 Mar 2021 after approval from the Institutional Ethical Committee. Patients were managed according to the guidelines and hospital protocol. After stabilization, the data was collected. Age, sex, address, patient’s history of diabetes, and hypertension were noted. Patients` serum was sent for serum electrolytes level and also serum magnesium level. Patients were labeled as hypomagnesemia and Hypokalemia as per operational definitions.
RESULTS: The Mean and SDs for age were 57.52+9.155. The Mean and SDs for the serum level of potassium were 4.93+0.806. The Mean and SDs for the serum level of magnesium were 1.22+0.423. Thirty-four (18.4%) patients were recorded in the 35-50 years age group while 151 (81.6%) patients were recorded in the 51-72 years age group. 144 (77.8%) male patients and 41 (22.2%) female patients were recorded. Diabetes mellitus was present in 42 (22.7%). Hypertension was present in 37 (20.0%) patients. 9 (26.5%) patients had past five days’ history of diuretics usage. 18 (9.7%) patients were recorded with Hypokalemia. Ninety-eight (53.0%) patients were found to have hyperkalemia. A total of 185 patients admitted to the CCU of our hospital having ventricular tachycardia were included in this study, out of which 70 (37.8%) patients having ventricular tachycardia were recorded with hypomagnesemia. 19 (38.8%) patients with diuretics induced Ventricular Tachycardia had hypomagnesemia and while remaining 51 (37.5%) patients with ischemic Ventricular Tachycardia and VT-RVOT respectively were recorded with hypomagnesemia (P Value = 0.875)
CONCLUSION: The data suggest that magnesium deficiency does occur in ventricular tachycardia with an increased incidence of cardiac arrhythmias.
KEYWORDS:
Cardiovascular Disease, Ventricular Tachycardia, Hypomagnesemia
Necrosectomía endoscópica transmural a través de fístula pancreático gástrica espontánea secundaria a necrosis encapsulada infectada
Authors: Ramirez Garcia Juan , Vargas-Alayza César , Ravelo Natali
Published: July 2023

La clasificación de Atlanta hace una importante distinción entre las colecciones compuestas sólo por fluidos y las que contienen tejido necrótico. En este último grupo, la necrosis encapsulada o amurallada se refiere a una colección encapsulada de necrosis pancreática y/o peri pancreática que presenta una pared bien definida. Cuando es asintomática el tratamiento es conservador; cuando está infectada requiere drenaje.La ruptura espontánea de la necrosis encapsulada hacia el tracto gastrointestinal es un evento raro. Presentamos el caso de una paciente con una hemorragia digestiva alta secundaria a una fístula pancreático gástrica ocasionada por una necrosis pancreática encapsulada infectada. Días después de realizada la endoscopía alta debido a la hemorragia, se observó un incremento en el diámetro de la fístula, a través de la cual se realizó exitosamente la necrosectomía endoscópica, logrando que la paciente mejorara notablemente luego de la segunda sesión.
Uso de plasma rico en plaquetas autólogo en el tratamiento de la fisura anal crónica: una serie de casos
Authors: Ortega Pérez Neith
Published: July 2023

Introducción. La fisura anal crónica constituye una de las patologías proctológicas más frecuentes e invalidantes. Su manejo terapéutico se complica en pacientes con recidivas o riesgo elevado de incontinencia anal.
Objetivo. Evaluar la efectividad de la infiltración de plasma rico en plaquetas autólogo para lograr la cicatrización de la fisura anal crónica.
Material y métodos. Se llevó a cabo un estudio observacional retrospectivo descriptivo en 16 pacientes tratados con plasma rico en plaquetas autólogo en nuestro centro por fisura anal crónica.
Resultados. La evolución fue satisfactoria en todos los pacientes ya que en el 94% de ellos había disminuido o desaparecido la proctalgia durante las primeras 48 horas y, al mes del tratamiento, en el 89% de los pacientes había cicatrizado la fisura. Limitaciones: Este estudio estuvo limitado por el pequeño tamaño de la muestra. Asimismo, no se informó el seguimiento a largo plazo de los pacientes.
Conclusión. El uso de plasma rico en plaquetas autólogo puede plantearse como una alternativa para el tratamiento médico de la fisura anal, con buenos resultados, destacándose la resolución de la proctalgia en las primeras 48 horas.
Adenoma Detection Rate at Different Age Intervals Suggests Starting Colorectal Cancer Screening at 45 Years of Age
Authors: Gutiérrez Castro Bleenis , Fernández José Luis , Cassella Federico , Wonaga Andrés , Viola Luis
Published: July 2023

Introduction. It is uncertain whether starting screening at 45 years old would improve colorectal cancer prevention and currently available studies in adults younger than 50 years old are limited.
Aim. To evaluate the adenoma detection rate at different age intervals.
Materials and methods. Colonoscopies performed on adult outpatients were analyzed. Adenoma detection was recorded in the total population and in patients with screening indication. First, patients were divided into two groups: 50 years or older (group A) and younger than 50 years (group B). Then, we analyzed the different age segments: up to 44 years (group 1) 45 to 49 (group 2), 50 to 54 (group 3), and 55 or older (group 4).
Results. A total of 5090 patients were included, 2877 with indication for screening. Patients were divided as follows: 3883 in group A, 1207 in group B, 811 in group 1, 396 in group 2, 749 in group 3 and 3134 in group 4. In the total population, adenoma detection was 20.5%: 23.5% in group A, 10.5% in group B (p = 0.000); 8.3% in group 1, 14.8% ingroup 2, 18.1% in group 3, and 24.8% in group 4 (group 1vs. group 2: p = 0.001, group 2 vs. group 3: p = 0.189, andgroup 3 vs. group 4: p = 0.000). In the screening population,adenoma detection was 20.5%: 21.4% in group A, 14.8%in group B (p = 0.004); 13.1% in group 1, 17.0% in group2, 16.1% in group 3, and 22.8% in group 4 (group 1 vs.group 2: p = 0.31; group 2 vs. group 3: p = 0.81; and group3 vs. group 4: p = 0.001). Conclusion. Adenoma detectionis not different between 45 to 49 and 50 to 54 years of age,and is lower below 45 years of age, which suggests startingcolorectal cancer screening at this age.
Desnutrición y sarcopenia en los pacientes con cirrosis hepática: la importancia de la evaluación nutricional y las intervenciones basadas en la evidencia
Authors: Schaab Sara Noemí
Published: July 2023

La desnutrición y la sarcopenia se presentan con frecuencia en los pacientes con cirrosis hepática. Se estima una prevalencia entre el 23% y el 60%, que puede ser aún mayor en los pacientes en lista de espera de trasplante hepático. Ambas condiciones se asocian con una mayor tasa de complicaciones y son predictoras independientes de menor sobrevida.1
La etiología de la desnutrición/sarcopenia en la cirrosis hepática es multifactorial y resulta de la combinación de alteraciones en la ingesta y en la digestión, absorción y metabolismo de los nutrientes. La ingesta dietética deficiente puede ser consecuencia de síntomas gastrointestinales, anorexia, disgeusia, ayunos prolongados y prescripciones dietéticas inadecuadas. La malabsorción podría ser secundaria a la hipertensión portal o a enfermedades colestásicas. Sin embargo, la alteración en el metabolismo de los macronutrientes es un mecanismo central que contribuye de forma significativa a la desnutrición, ya que la resistencia periférica a la insulina y la reducción de los depósitos de glucógeno hepático promueven la gluconeogénesis precoz, conduciendo al catabolismo proteico y lipídico. Esto puede ocurrir ante un ayuno nocturno corto y asemejarse al estado catabólico de sujetos sanos sometidos a 2-3 días de inanición.2
Adenoma de las glándulas de Brunner: Causa infrecuente de hemorragia digestiva alta. Reporte de caso
Authors: Allende Marina , Manazzoni Dante , Pérez Tomas , Santino Juan , Abecia Victor Hugo , Marcolongo Mariano
Published: July 2023

Reportamos el caso de un paciente masculino de 56 años de edad que ingresa por un cuadro de melena. Se le realiza una videoendoscopía alta de urgencia en la que se observa una lesión polipoidea subpediculada de superficie congestiva, de aproximadamente 5 cm, ubicada en la tercera porción duodenal. Se realizó la resección endoscópica de la lesión en un segundo tiempo y su estudio histopatológico informó un adenoma de las glándulas de Brunner. Presentamos este caso por lo infrecuente de esta patología como causa de hemorragia digestiva.
Dolor abdominal crónico posterior a derivación gástrica
Authors: Loaiza Pacheco Ivonne , Granel Juana , Tregea Candelaria , Ferrarotti Carlos , Larrañaga Nebil
Published: July 2023

Paciente femenina de 42 años con antecedente quirúrgico de derivación gástrica en Y de Roux por vía laparoscópica realizada hace 12 meses, consulta al Servicio de Gastroenterología por presentar epigastralgia. Se le solicita, en primera instancia, un estudio seriado esófago gastroduodenal con doble contraste.
Novosheshminskie shaft and Sheremshanskaya fortress as components of the Zakamskaya process line and the New Zakamsk defense line
Authors: Menshov A. V.
Published: July 2023

This article discusses small sections of the Zakamskaya defensive line and the New Zakamskaya defensive line, the reasons for their construction, life in these fortifications and the main events associated with them. The prospect of studying and museumification of these monuments of cultural heritage is also considered
Photography in the Museum: Problems of Research
Authors: Rubinina Z. M.
Published: July 2023

The article is devoted to problems during research work with photographs belonging to the Russian Federation Museum Fund within the framework of historical science, from heuristics to information value of photographic documents. Within the context of the problems of identifying and selecting photographs from museum collections, possibilities and disadvantages of electronic catalogs are considered on the example of the State Catalog of the Russian Federation Museum Fund. The problem of insufficient and incorrect attribution of the national photographic heritage is considered. The reasons for the rare appeal of historians to photography as a full-fledged historical source are analyzed. In this regard, a number of source problems have been identified, without solving which, the formation of photography as a historical source seems difficult. Attention is also paid to the problem of archeography of photographic documents in publications of both typographic and non-typographic forms. Possibilities of photography as an informational source and prospects of its use in historical research are analyzed.
Festivals in ethnoculture of the peoples of Tatarstan
Authors: Shaidullin R. V.
Published: July 2023

The article is devoted to certain aspects of ethnoculture of the peoples of Tatarstan, with regards to historical context of the development of festival movement in the republic. The paper gives a brief specific description of festivals, as well as a special role of multinational amateur art groups in the development and popularization of national traditions and customs of the peoples of Tatarstan. In addition, the article examines the role of festivals in the PR of territories, folk traditions and event tourism. It pays some attention to the problems of educating young people on the ethno-cultural traditions of previous generations, as well as local economic components of the growth of the festival movement through the prism of the development of the recreational and tourism industry.
"They replaced the tv and the cinema and the book" – some storylines of Moscow stove tiles of the XVII century
Authors: Glazunova O. N.
Published: July 2023

The article is about the appearance of the first tiled stoves in Moscow, the transfer of ornaments, it describes some of the plots of early Moscow tiles, plots borrowing and tile series appearance. The origins of images are determined, including the illustrations to Russian folklore stories. The changes of plots over time are demonstrated.
Historical and cultural heritage of the Great Patriotic War: Alaska-Siberia air route
Authors: Filin P. A.
Published: July 2023

The article is devoted to the results of the expedition of the Russian Geographical Society and the Ministry of Defense of the Russian Federation to survey the airfields of the Alaska-Siberia air route in 2021–2022 in order to identify and describe objects related to the history of the formation of this route. Particular attention is paid to the objects of architectural heritage that have been preserved since the Great Patriotic War. The question of the need to preserve and further museumification of these objects is indicated. In addition, an overview of the identified technical objects is given – crashed aircraft, special vehicles, machine tools and other objects related to the history of the route. Proposals were made to create a special museum dedicated to the history of the Alaska-Siberia air route.
Buranа minaret – past and present study
Authors: He Feng , Imankulov D. D.
Published: July 2023

Buranа minaret studies have a half-century history. Not all old sources are still known, and existing sources cannot yet provide sufficient information about this amazing architectural monument. The article is devoted to the analysis of information about the Buranа minaret in order to replenish the holistic picture of the study of the monument.
Funds of Knowledge of the Semai Orang Asli Children in Science Learning: A Needs Analysis
Authors: Osman Azizah , Halim Lilia , Mohamad Arsad Nurazidawati
Published: July 2023

Malaysia always strives to provide high-performance education for its citizens by emphasising on the principle of equality that prioritises quality education for every child. However, the performance of Orang Asli (indigenous) children in science education is still lagging far behind as a result of their difficulty in understanding scientific concepts of science which they feel are foreign to their culture. Thus, a needs analysis study was conducted to identify the science topics that are the most difficult for primary school year five Semai Orang Asli children to understand and the elements of funds of knowledge (FOK) that can be applied in science teaching for these difficult topics. This needs analysis was conducted using survey research design with interview method. The study sample comprised three students and four teachers in an Orang Asli school in the district of Slim River, Perak. The needs analysis found that Electricity is the most difficult topic to be taught to and understood by the Orang Asli children. In addition, the findings also showed that the elements of FOK of the Orang Asli such as family values, hobbies, parents’ occupation, language, religion, tradition and school’s co-curricular activities can be applied in science teaching to bring the science concepts that are considered difficult into their lives. In conclusion, the FOK elements identified from the needs analysis are expected to be able to help educators and researchers design science teaching that is more equitable in upholding the principles of equity in education in Malaysia.
Comparison of Financial Distress Predictions With Altman, Springate, Zmijewski, and Grover Models
Authors: Martini Rita , Raihana Aksara Rana , Rachma Sari Kartika , Zulkifli Zulkifli , Hartati Sukmini
Published: July 2023

Several predictive models of financial distress and corporate bankruptcy have been developed. In this study, the Altman model (Z-Score), the Springate model (S-Score), the Zmijewski model (X-Score), and the Grover model (G-Score) were used. These methods are used to analyze the potential for financial difficulties which in the end to determine the potential for bankruptcy at PT Garuda Indonesia (Persero) Tbk. The secondary data used is in the form of financial statements for 2018-2020. The results of the bankruptcy prediction using the Altman model resulted in PT Garuda Indonesia (Persero), Tbk being in the bankrupt area, which experienced financial difficulties in 2018 to 2020. The Springate model was in a distress position and went bankrupt in 2018 and 2020, while in 2019 is in the gray area. Then the Zmijewski model is in a state of bankruptcy, which is experiencing financial difficulties and has the potential to go bankrupt in three years. Grover's model shows the company was in a state of bankruptcy in 2018 and 2020, and safe in 2019.
Ասփակի վանական համալիրը
Authors: Նահատակյան Դավիթ Ս. , Ակոպով Արկադի Ա. , Գրիգորյան Անի Ա.
Published: July 2023

Ասփակի վանական համալիրը գտնվում է պատմական Մեծ Հայքի Տայք նահանգի Բողխա գավառի Ասփակ (այժմ՝ Դարիջա) բնակավայրի մոտ: Համալիրը բաղկացած է գլխավոր եկեղեցուց, աղյուսաշեն եկեղեցուց, մատուռ-դամբարանից, պարսպապատով մուտք-աշտարակից, հարավային եկեղեցուց: Վանական համալիրում պահպանվել են նաև հավանաբար ուշ միջնադարին բնորոշ բնակելի և օժանդակ կառույցներ, որոնք իրենց քարի պատերի ու փայտե ծածկերի ճարտարապետությամբ արժեքավոր են, սակայն իրենց լուծումներով հնուց ի վեր հայտնի են հայկական ճարտարապետությանը: Համալիրի կառույցներն իրենց ճարտարապետական լուծումներով հետաքրքիր են և ուշադրության արժանի, իսկ ընդհանուր լուծումներով կարևոր տեղ են զբաղեցնում միջնադարյան հայկական ճարտարապետության մեջ:
Aspak monastic complex is located near the village of Aspak (now Darica) of the Boghkha district of the historical Tayk province of Greater Armenia. The complex consists of the main church, a brick church, a chapel-tomb, a gate-tower with walls, and a southern church. The monastery complex has also preserved residential and auxiliary buildings typical of the late Middle Ages, which are valuable for their architecture of stone walls and wooden coverings, but their solutions have been known to Armenian architecture since ancient times. The buildings of the complex are interesting and noteworthy for their architectural solutions, and their general solutions occupy an important place not only for the Ughtik district of the historical province of Tayk, but also for pan-Armenian medieval architecture in general.
Монастырский комплекс Аспак расположен недалеко от поселка Аспак (ныне Дариджа) округа Богха исторической провинции Тайк Великой Армении. Комплекс состоит из главной церкви, кирпичной церкви, часовни-усыпальницы, входом-башней со стенами, южной церкви. В монастырском комплексе также сохранились типичные для позднего средневековья жилые и вспомогательные строения, которые ценны своей архитектурой каменных стен и деревянных покрытий, но такие решения известны армянскому зодчеству с древних времен. Сооружения комплекса интересны и достойны внимания своими архитектурными решениями, а общими решениями занимают важное место не только для округа Ухтик исторической провинции Тайк, но и для общеармянского средневекового зодчества в целом.
Ազգային ինքնության պահպանման դրսևորումը Քերոլ Էդգարյանի «Եփրատի մակընթացությունը» վեպում
Authors: Գալստյան Նելլի Բ.
Published: July 2023

Ամերիկահայ անգլիագիր Քերոլ Էդգարյանն իր գրչակիցների հետևողականությամբ ամերիկահայության առջև ծառացած բազում դժվարությունները, հոգեբանական խնդիրները հաղթահարելու, ինքնությունը պահպանելու նպատակով դիմել է սերնդեսերունդ փոխանցված ավանդույթների, սովորույթների, կենսափորձի, վարքու-բարքի, հավատալիքների, ազգը շարունակաբար վերածնող, վերաիմաստավորող, վերականգնող էթնիկ հիշողությանը:
American-Armenian English-speaking writer Carol Edgaryan, following the example of her fellow writers, overcoming many difficulties and psychological problems of American Armenians, in order to preserve national identity, turned from generation to generation to traditions, customs, life experience, customs, ethnic memory, which continuously reviving and restoring the nation․
Американо-армянская англоязычная писательница Кэрол Эдгарян, по примеру своих коллег-писателей, преодолевая многие трудности и психологические проблемы американских армян, с целью сохранения национальной идентичности, обращалась из поколения в поколение к традициям, передающимся обычаям, жизненному опыту, нравам, этнической памяти, которая непрерывно возрождала и восстанавливала нацию․
Construção da Identidade Docente no Âmbito do Programa Residência Pedagógica
Authors: Aghta Pantano Souza Gahelyka , Guimarães Orliney Maciel
Published: July 2023

O objetivo deste artigo foi o de analisar como o Programa de Residência Pedagógica favorece a construção da identidade docente de licenciandos em Química de uma instituição pública de ensino superior. Com abordagem metodológica de uma pesquisa qualitativa, os instrumentos de produção de dados foram o grupo focal e a técnica de associação livre de palavras, e os sujeitos foram oito estudantes de licenciatura em Química participantes do programa. Os resultados apontaram que a participação no programa favoreceu mudanças nas concepções dos participantes da pesquisa sobre ser professor de Química e sobre o trabalho docente. A visão sobre o domínio dos conceitos e conteúdos deu lugar a uma visão mais estruturada de como esses devem ser abordados e da importância das interações professor-aluno para mediar esse processo de construção do conhecimento. Os participantes perceberam que o trabalho docente, muitas vezes, é desvalorizado pela escola, que interfere no trabalho do professor, nem sempre de forma positiva; bem como evidenciaram as condições precárias do trabalho docente. Assim, a identidade docente dos estudantes está vinculada tanto à dimensão educacional como à dimensão contextual.
PIBID/QUÍMICA/UFPB em Período Remoto: A Importância da Educação Inclusiva na Formação de Professores
Authors: Suelen de Freitas Reis Santos Emelly , Hoffimam Miranda Nunes Paulino Ellem , Da Silva Madruga Maria Francileide , Ferreira Barbosa Karoline , Lima-Junior Claudio Gabriel
Published: July 2023

O trabalho relata a vivência de bolsistas participantes do Programa Institucional de Bolsa de Iniciação à Docência (PIBID) do subprojeto Química da Universidade Federal da Paraíba (UFPB) do Campus I – João Pessoa. Ela ocorreu em período remoto durante a pandemia do COVID-19, em uma turma do 2º ano do Curso Técnico Integrado de Meio Ambiente do Instituto Federal de Educação, Ciência e Tecnologia da Paraíba (IFPB) no Campus Cabedelo. De forma particular, mostra ações desenvolvidas no âmbito da educação inclusiva, na qual buscou-se promover atividades síncronas e assíncronas com o objetivo de promover uma maior participação de todos os alunos, incluindo uma aluna surda, na disciplina de Química II. O trabalho possui natureza qualitativa e utilizou da metodologia de observação participante, diário de bordo, realização de entrevista e aplicação de questionário como instrumentos de coleta de dados. A elaboração de videoaulas por parte das pibidianas com presença de uma intérprete, realização de uma gincana química em modelo remoto e uma atividade experimental com registro em vídeo foram realizadas. Foi observado que as ações planejadas pelo professor juntamente com as pibidianas e Núcleo de Apoio à Pessoas com Necessidades Especiais (NAPNE) do IFPB promoveu maior engajamento dos estudantes. O professor da disciplina, as pibidianas e a aluna surda apresentaram seus relatos frente às principais dificuldades encontradas, confirmando a importância do programa PIBID para promover um ambiente de profunda reflexão/interação, oportunizando aos licenciandos em Química, uma melhor formação inicial também no contexto da educação inclusiva.
Os Quatro Elementos – Uma Proposta de Oficina de Química Ambiental
Authors: Leal de Carvalho Evelyn , Domingues de Almeida Lucas , Da Costa Ferreira Letícia , Ramos Vaz Ygor , De Lima Guimarães Taís Cristina
Published: July 2023

A Química Ambiental vem sendo cada vez mais discutida nos últimos anos. Além disso, por compreender diversas áreas de ensino, permite trabalhar de forma interdisciplinar, abrangendo um vasto campo de conhecimento. A partir disso, pensou-se em uma metodologia capaz de associar o conteúdo com o cotidiano, a experimentação, onde foi possível mostrar problemas reais e provocar o interesse do aluno. Foram utilizados experimentos associados aos quatro elementos: terra, ar, água e fogo. A água e a terra foram trabalhadas a partir de problemas de poluição e qualidade da água, enquanto o ar e o fogo foram trabalhados através de problemas de poluição atmosférica. Além disso, todas trabalharam os conceitos químicos aliado a questões socioambientais relevantes e que se mostram presentes no entorno da escola. Desta forma, a oficina teve como objetivo principal demonstrar a importância da Educação Ambiental no ensino. Este trabalho é resultado do Programa de Residência Pedagógica, realizado no CIEP 170 - Gregório Bezerra, em São João de Meriti – Rio de Janeiro, por licenciandos do IFRJ - Campus Duque de Caxias.
A Atuação do Programa Residência Pedagógica no Município de Coari-AM
Authors: Silva Geovani Rodrigues , de Lima Yamaguchi Klenicy Kazumy
Published: July 2023

O Programa Residência Pedagógica (PRP) possui o objetivo de incentivar a formação docente a partir da segunda metade do curso, contribuindo com a melhoria na qualidade dos cursos de licenciatura, e possibilitando ao licenciando o contato direto com a prática escolar. Essa pesquisa buscou averiguar a importância da inserção dos residentes do PRP da Universidade Federal do Amazonas nas escolas do município de Coari (Amazonas), entendendo as dificuldades, pontos positivos e negativos da atuação desses futuros docentes no ambiente escolar. A pesquisa exploratória foi realizada com residentes dos cursos de Ciências (Biologia, Química e Física) atuantes em escolas públicas do Ensino Fundamental e Médio, com abordagem qualitativa e quantitativa. Verificou-se embora os residentes ainda não se sintam preparados para atuarem como docentes, houve um maior amadurecimento dos residentes nos três núcleos (Química, Biologia e Física).
Description of electroneuromyographic findings in leprosy: confirming a spectral neuropathy
Authors: Borges Isabella Sabião , Neres Agnes Laura Silva , Silva Gabriella Louise Constantino , Pena Vinícius Moura Abbud , Oliveira Ana Clara Gondim , Carvalho Iago Resende , Samper Isabela Correa , Antunes Douglas Eulálio , Goulart Isabela Maria Bernardes , Santos Diogo Fernandes dos
Published: July 2023

Introduction: Leprosy is the most common cause of peripheral neuropathy, leading to sequelae that perpetuate the stigma linked to the disease. Electroneuromyography (ENMG) is the gold standard to evaluate neural damage, as it can detect even subclinical alterations. Objectives: To describe the electroneuromyographic findings in leprosy patients. Methods: Retrospective analysis of the records from patients with leprosy in a Brazilian Reference Center, between 2014 and 2021. The sensibility conduction of the median, ulnar, radial, sural and peroneal nerves, and motor conduction of the median, ulnar, peroneal and tibial nerves were analyzed. Results: Five hundred and thirteen patients with leprosy submitted to ENMG at the diagnosis were analyzed. The mean age was 45.8 years (±16.6) with 50.1% being male, and multibacillary represented 85.8% of the cases. Of these patients, 71.9% presented neural damage compatible with leprosy. In total, 2,627 damaged nerves were found, with a mean of 7.1 (±5.2) per patient. The most affected sensitive nerve was the superficial peroneal 15.8%, with a mean of 4.4 (±3.3) damaged nerves per patient. The most affected motor nerve was the ulnar 12.9%, with a mean of 2.7 (±2.5) damaged nerves per patient. Between the 369 patients with neural leprosy damage, 19.2% presented with mononeuropathy, while 80.8% presented two or more damaged nerves. Asymmetric sensorimotor axonal neuropathy with focal slowing of conduction velocity was the most common ENMG pattern 53.9%. Conclusion: Leprosy is a spectral disease, therefore, the damage and neurophysiological characteristics can vary according to the clinical presentation. The ENMG pattern confirms that there is a greater involvement of sensitive nerves asymmetrically, mainly axonal, with localized non-uniform myelin damage.
Super refractory status epilepticus in a child: brain on “fires”
Authors: Azevedo Ruan de , Barbosa Adriel , Souza Gabriel de , Férrer João , Lima Márcio , Fraiman Pedro , Maffei Rafael , Faria Victor de , Lima Vinicius , Amorim Andre , Aragão Marcelo
Published: July 2023

Introduction: New onset of a refractory status epilepticus (NORSE) is a clinical presentation, without a clear cause, within the first 72h of admission of a non-epileptic patient. FIRES (Febrile Infection-Related Epilepsy Syndrome) is a NORSE subgroup with febrile prodrome 24 hours to 2 weeks before the onset of status. This case reports a previously healthy 7-year-old female with FIRES and super refractory status epilepticus (SE). Methods: This is a case report based on retrospective analysis of a single patient’s medical record. Results: The patient presented with SE four days after low grade fever and airway infection. Midazolam (MDZ) 0.15 mg/kg, phenytoin (PFT) 30 mg/ kg, phenobarbital (PB) 15 mg/kg were administered in sequence; followed by continuous infusion of MDZ 1 mg/kg/h and ketamine (KET) 30 mcg/kg/ min. Empirical treatment started with ceftriaxone, acyclovir and ampicillin. Exams on admission: Brain magnetic resonance (MRI) with no abnormalities; normal serum leukocyte count and electrolyte levels; cerebrospinal fluid (CSF) with 61 cells (71% lymphocytes), protein 38, Lactate 15, glucose 61 (mg/dL). CSF on two different occasions was negative for infectious agents and autoimmune antibodies. Electroencephalograms (EEG) on the 3rd, 4th and 7th days after hospitalization revealed SE despite the followings drugs: Levetiracetam 60 mg/kg, Lacosamide 10 mg/kg, topiramate 10 mg/kg, MDZ 2 mg/kg/h, KET 2 mg/kg/h. Throughout hospitalization, she received a 3 days course of methylprednisolone 30 mg/kg/day, followed by five days of immunoglobulin 2 g/ kg/day, ketogenic diet and thiopental 5 mg/kg/h. From the 13th day on, EEG maintained global suppression and no epileptiform activity. The patient died on the 18th day after a septic shock. Conclusion: NORSE and FIRES are entities with unfavorable outcomes and high mortality rates. Autoimmune/inflammatory encephalitis represents 40% of NORSE causes.
Primary CNS lymphoma mimicking demyelinating disease
Authors: Pozzobon Pedro , Sousa-Santos Patrick , Alvarenga Tarcisio , Baston Ana Beatriz , Lemos Ana Flavia , Foloni Maria C. , Dantas Gabriela , Coronetti Fernando , Lopes Laura Cardia
Published: July 2023

Case report: Male, 32-year-old, diagnosed with COVID-19 (coronavirus disease) in January 2022 and two weeks later present progressive vertigo, gait instability, binocular diplopia and right facial palsy. Three months later he was sent for investigation in our service. Magnetic resonance imaging (MRI) showed a FLAIR-hyperintense lesion in the pontomesencephalic transition with gadolinium enhancement. Cerebrospinal fluid (CSF) analysis shows increase in protein level (83 mg/dL). In this moment, considering the infectious antecedent and MRI characteristics, he has been diagnosed with acute disseminated encephalomyelitis (ADEM) and submitted to pulse therapy with methylprednisolone, showing complete improve of symptoms. In outpatient follow-up he presents with worsening of symptoms. Ten months after onset of symptoms he was hospitalized again, MRI showed new lesions on medulla and cerebellum. Submitted to pulse therapy followed by plasma exchange, with no improve. New MRI presents with infiltrative lesion without gadolinium enhancement. CSF analysis show 48 cells (98% lymphocytes), no evidence of neoplastic cells. A biopsy was performed on the lesion and showed atypical lymphoid infiltrate with B-Cells predominance, positive to CD20 and CD45, confirming diagnosis of Primary CNS Lymphoma (PCNSL). Initiated chemotherapy, but unfortunately patient die in consequence of neutropenia. Discussion: PCNSL is an uncommon neoplasm and rarely affects brainstem. When it occurs the prognosis is poor, nearly half of patients died within 1 year after diagnosis. Glucocorticoids could promote tumor shrinkage. Neuroimaging characteristics could be confounding with infections, demyelinating lesions, and gliomas. Conclusion: Our case illustrates a patient initially diagnosed with ADEM and submitted to corticotherapy with good response, however he worse in months later and the diagnosed reviewed to PCNSL. This shows the importance of considering atypical PCNSL in differential diagnosis of demyelinating diseases.
Prevalence of sexual dysfunction in men with ischemic stroke: a cross-sectional study
Authors: Chung Gabriel , Assunção Darah Fontes da Silva , Silva Lohana Santana Almeida da , Freitas Luiza Ramos de , Prado Marcelle Sanjuan Ganem , Kormanski Matheus Kohama , Freitas Paulo Henrique Maia de , Lopes Rônney Pinto , Marcusso Rosa Maria Nascimento , Gagliardi Rubens José
Published: July 2023

Introduction: Stroke is the leading cause of disability worldwide. Late complications, such as sexual dysfunction, have a direct impact on psychological and emotional aspects and directly affect the quality of life of these patients. Objectives and methods: We present a cross-sectional study that aimed to determine the prevalence of sexual dysfunction in patients with ischemic stroke followed in the neurovascular outpatient clinic of a tertiary hospital in São Paulo, Brazil, using the Male Sexual Quotient (MSQ) questionnaire. The MSQ can range from 0-100 points. Higher values indicate better sexual performance/satisfaction and a score of 60 points or less was considered as having sexual dysfunction. Casuistics and results: Fifty eight questionnaires were analyzed and classified according to the MSQ score. Mean age was 60 years and median MSQ score was 64 points. Of the interviewees, 24.14% had their sexual performance classified as poor-null, 17.24% of patients had poorunfavorable sexual performance, 6.90% as unfavorable-regular; regulargood and good-great sexual performance were equally found in 25.86% of the subjects. Discussion and conclusion: In this study, almost half of post-stroke men have sexual dysfunction according to MSQ, indicating a high impact of such a condition in the quality of life of our patients due to its prevalence. Thus, the health professional dealing with post-stroke patients must be aware and prepared to help patients in coping with sexual dysfunctions.
Use of FilmArray® in the diagnosis of bacterial meningitis
Authors: Senne Carlos , Giafferi Carlos , Vega Márcio , Salomão Daiane , Domingues Renan
Published: July 2023

Introduction: The Meningitis/Encephalitis FilmArray is an automated multiplex polymerase chain reaction for identifying 14 central nervous system (CNS) care agents, including viruses, Cryptococcus, and bacteria. The following bacteria are tested: E. coli K1, H. influenzae, L. monocytogenes, N. meningitidis, S. agalactiae and pneumoniae. In this study we compared the performance of FilmArray® with conventional microbiological methods for bacterial meningitis. Methods: We retrospectively evaluated data from 903 patients with CNS infection manifested by the method. Results: 42 cases were positive for bacteria, E. coli K1=2, H. influenzae=7, L. monocytogenes=5, N. meningitidis=9, S. pneumoniae=20. Of these, only 14 (33.34%) were positive with conventional microbiological methods, including culture and/or bacterioscopy. Three patients were negative on FilmArray® and positive with other methods: 2 culture positive (S. intermedius and Micrococcus) and one Gram negative. All 28 cases positive only with FilmArray® adopted a cerebrospinal fluid infection pattern suggestive of bacterial meningitis: pleocytosis with neutrophilic predominance, increased protein and lactate, and hypoglycorrhachia. Conclusion: The study confirms previous data indicating that FilmArray® increases the sensitivity of etiological diagnosis of bacterial meningitis.
Cardiovascular risk in adults with drug-resistant epilepsy submitted to the modified atkins diet
Authors: Silveira Rayanne Maria Brandão da , Gregório Marcela Marques de Oliveira , Yacubian Elza Marcia Targar , Guilhoto Laura Maria de Figueiredo Ferreira
Published: July 2023

Introduction: The modified Atkins diet (MAD) the carbohydrates are limited to 15–30 g/d and high fat intake is encouraged. It are used in children, being less studied in adults Objectives: To assess the impact of MAD over a 6-month period in adults with drug-resistant epilepsy in terms of reduction in seizure frequency and cardiovascular risk. Methods: Prospective and interventional study.Inclusion criteria:patients aged 18–60 yrs, with drug-resistant focal epilepsy, without surgical indication or in the postoperative of epilepsy surgery. Exclusion criteria were: use of corticosteroids, metabolic diseases, cholecystectomy or nephrolithiasis, inadequate nutrition, uncooperative parents or caregivers and inadequate sociofamily dynamics. All started the diet at a 1:1 ratio and ASMs. Study periods: baseline (P0), six month (P6). Carotid and vertebral Doppler ultrasounds were performed at P0 and P6 in order to assess possible alterations related to of the carotid arteries the intima-media thickness. Results: Twenty patients are being followed up, 12 of which started the MAD, and of these, 6 completed the six-month period of diet therapy and underwent pre and post-diet exams. The 6 patients showed no increase in mean total, low-density lipoprotein, triglycerides cholesterol levels.There was no change in the thickness of the myointimal complex of any patient, made by comparative analysis by ultrasonographic exam before and after six months of starting the diet. Four out of 6 patients had >50% reduction in seizures (two seizure free) and two had no change in frequency. Conclusion: MAD for six months in adults with drug-resistant focal epilepsy had a significant effect on the reduction of epileptic seizures and did not reveal alterations in the myointimal wall of the carotid arteries.
High-resolution ultrasonography: a diagnostic tool for early diagnosis of neural impairment in leprosy
Authors: Luppi Andrea de Martino , Antunes Douglas Eulálio , Oliveira Ana Clara Gondim , Barbosa Marcello Henrique Nogueira , Vitorino João Augusto Nunes , Pinheiro Beatriz Iolanda de Sene Ferregutti , Samper Isabela Corrêa , Neves Agnes Laura Silva , Pena Vinícius Moura Abbud , Santos Diogo Fernandes dos , Goulart Isabela Maria Bernardes
Published: July 2023

Introduction: Leprosy household contacts (HC) have high chances to develop leprosy. Anti-PGL-I IgM seropositivity also increases the risk of illness. Objectives: Identify neural impairment in leprosy HC by analyzing differences in high-resolution ultrasonographic (US) measurements of peripheral nerves between HC and healthy volunteers (HV). Methods: Seventy nine seropositive household contacts (SPHC), 30 seronegative household contacts (SNHC) and 53 HV underwent dermato-neurological examination and laboratorial analysis, followed by high-resolution US evaluation of cross-sectional areas (CSAs) of the median, ulnar, common fibular and tibial nerves. Results: Neural thickening was clinically observed in only 2% of SPHC and none of the SNHC. None of the HC presented skin lesion, sensory symptoms or muscular weakness. The US evaluation detected neural thickening in 26.5% of the SPHC and only in 3.3% among the SNHC. Among SPHC with thickening detected by US, the mean number of nerves affected was 1.8 per contact, while 53.8% presented mononeuropathy and 46.2% presented multiple mononeuropathy. The nerves most affected were the common fibular and the tibial nerves. The CSA of the common fibular, tibial at the tunnel and tibial proximal to the tunnel were significantly higher in SPHC compared to the other groups, being asymmetrical in the fibular and tibial nerves. SPHC presented a 10.5-fold higher chance of neural impairment. Conclusion: There is a prevalence of neural thickening in SPHC and US in very important to the early diagnosis. The positive anti-PGL-I serology can identify individuals with greater chances of developing leprosy neuropathy, who should be referred for US examination.