bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of artificial intelligence: risk perception and trust in the work context with different impact levels and task types
Authors: Klein Uwe , Depping Jana , Wohlfahrt Laura , Fassbender Pantaleon
Published: June 2023

Following the studies of Araujo et al. (AI Soc 35:611–623, 2020) and Lee (Big Data Soc 5:1–16, 2018), this empirical study uses two scenario-based online experiments. The sample consists of 221 subjects from Germany, differing in both age and gender. The original studies are not replicated one-to-one. New scenarios are constructed as realistically as possible and focused on everyday work situations. They are based on the AI acceptance model of Scheuer (Grundlagen intelligenter KI-Assistenten und deren vertrauensvolle Nutzung. Springer, Wiesbaden, 2020) and are extended by individual descriptive elements of AI systems in comparison to the original studies. The first online experiment examines decisions made by artificial intelligence with varying degrees of impact. In the high-impact scenario, applicants are automatically selected for a job and immediately received an employment contract. In the low-impact scenario, three applicants are automatically invited for another interview. In addition, the relationship between age and risk perception is investigated. The second online experiment tests subjects’ perceived trust in decisions made by artificial intelligence, either semi-automatically through the assistance of human experts or fully automatically in comparison. Two task types are distinguished. The task type that requires “human skills”—represented as a performance evaluation situation—and the task type that requires “mechanical skills”—represented as a work distribution situation. In addition, the extent of negative emotions in automated decisions is investigated. The results are related to the findings of Araujo et al. (AI Soc 35:611–623, 2020) and Lee (Big Data Soc 5:1–16, 2018). Implications for further research activities and practical relevance are discussed.
Workflow for shake flask and plate cultivations with fats for polyhydroxyalkanoate bioproduction
Authors: Riedel Sebastian L. , Donicz Ewelina N. , Ferré-Aparicio Paula , Santolin Lara , Marbà-Ardébol Anna-Maria , Neubauer Peter , Junne Stefan
Published: June 2023

Since natural resources for the bioproduction of commodity chemicals are scarce, waste animal fats (WAF) are an interesting alternative biogenic residual feedstock. They appear as by-product from meat production, but several challenges are related to their application: first, the high melting points (up to 60 °C); and second, the insolubility in the polar water phase of cultivations. This leads to film and clump formation in shake flasks and microwell plates, which inhibits microbial consumption. In this study, different flask and well designs were investigated to identify the most suitable experimental set-up and further to create an appropriate workflow to achieve the required reproducibility of growth and product synthesis. The dissolved oxygen concentration was measured in-line throughout experiments. It became obvious that the gas mass transfer differed strongly among the shake flask design variants in cultivations with the polyhydroxyalkanoate (PHA) accumulating organism Ralstonia eutropha. A high reproducibility was achieved for certain flask or well plate design variants together with tailored cultivation conditions. Best results were achieved with bottom baffled glass and bottom baffled single-use shake flasks with flat membranes, namely, >6 g L-1 of cell dry weight (CDW) with >80 wt% polyhydroxybutyrate (PHB) from 1 wt% WAF. Improved pre-emulsification conditions for round microwell plates resulted in a production of 14 g L-1 CDW with a PHA content of 70 wt% PHB from 3 wt% WAF. The proposed workflow allows the rapid examination of fat material as feedstock, in the microwell plate and shake flask scale, also beyond PHA production.

Key points

• Evaluation of shake flask designs for cultivating with hydrophobic raw materials

• Development of a workflow for microwell plate cultivations with hydrophobic raw materials

• Production of polyhydroxyalkanoate in small scale experiments from waste animal fat

Graphical Abstract
Humangenetische Diagnostik bei hereditären Augenerkrankungen
Authors: Neuhann Teresa M. , Neuhann Lukas
Published: June 2023

Hereditäre Augenerkrankungen können alle okulären Strukturen betreffen und mit strukturellen Auffälligkeiten (z. B. Kolobome) oder funktionellen Einschränkungen (z. B. Netzhautdystrophien) einhergehen. Zudem zeigen viele komplexe syndromale Krankheitsbilder als erstes Symptom eine Augenbeteiligung. Hereditäre Augenerkrankungen sind ausgesprochen heterogen, durch die modernen Hochdurchsatzsequenzierungen ist eine diagnostische Abklärung jedoch in der Routinediagnostik möglich. Dies ist nicht nur in der Differenzialdiagnostik, sondern auch zunehmend aufgrund individueller Therapieoptionen von hoher Relevanz.
Prevalence and determinants of loneliness among the oldest old living in institutionalized settings
Authors: Hajek André , Zwar Larissa , Gyasi Razak M. , Kretzler Benedikt , König Hans-Helmut
Published: June 2023

Background

There is very limited knowledge regarding the prevalence and determinants of loneliness in oldest old residents of nursing or old age homes.

Objective

To examine the prevalence and determinants of loneliness among the oldest old living in institutionalized settings in Germany.

Material and methods

Data were taken from the representative survey on quality of life and subjective well-being of the very old in North Rhine-Westphalia (NRW80+) including individuals ≥ 80 years living in North Rhine-Westphalia. The study focused on individuals living in institutionalized settings. Sociodemographic, lifestyle-related, and health-related determinants were included in multiple linear regression models.

Results

Approximately 56.6% of the individuals were not lonely, 25.7% and 17.8% of the individuals were moderately and severely lonely, respectively. Regression analyses showed that higher loneliness was associated with being married (β = 0.48, p < 0.05), high education (compared to low education, β = 0.46, p < 0.05), having a small social network size (β = −0.02, p < 0.05), having poor self-rated health (β = −0.25, p < 0.05), and more depressive symptoms (β = 0.25, p < 0.001).

Conclusion

A significant proportion of the institutionalized oldest old individuals reported moderate or severe loneliness, which underpins the relevance of this topic. Understanding the determinants of loneliness may help to address institutionalized adults aged 80 years and over at risk of loneliness.
The use of geochemical methods to pinpoint the origin of ancient white marbles
Authors: Prochaska Walter
Published: June 2023

“Multi-method-approach” has now been for many years the buzzword in marble provenance analysis. Nevertheless a true combination of the results of different analytical methods is rarely applied in the sense of the combined simultaneous use of a large number of analytically obtained numerical variables. It is demonstrated here that the combination of data from isotope analysis, chemical data, and data from the chemical analysis of inclusion fluids of an artefact and of course in combination with a corresponding database enhances substantially the accuracy of marble provenance analysis. It is explicitly pointed out that the unchallenged collection of data of the chemical composition of marbles from different sources (and different analytical procedures) most probably implies severe differences in their comparability. Exemplarily presented is the nearly perfect discrimination of the most important fine-grained marbles and furthermore the possibility of the intra-site discrimination of the three Carrara districts and the assignment of two portrait heads to the Carrara Torano quarries.
Correction to: On methodology and application of smoothed particle hydrodynamics in fluid, solid and biomechanic
Authors: Xu Fei , Wang Jiayi , Yang Yang , Wang Lu , Dai Zhen , Han Ruiqi
Published: June 2023

The article “On methodology and application of smoothed particle hydrodynamics in fluid, solid and biomechanics” (DOI: 10.1007/s10409-022-22185-x), written by Fei Xu, Jiayi Wang, Yang Yang, Lu Wang, Zhen Dai and Ruiqi Han, was originally published Online first without open access. After publication in volume [39], Article number [722185], the authors decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to ©The Authors 2023 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0. Open access funding enabled and organized by Projekt DEAL.

The original article has been corrected.
Current state-of-the-art on ganglioside-mediated immune modulation in the tumor microenvironment
Authors: van der Haar Àvila Irene , Windhouwer Britt , van Vliet Sandra J.
Published: June 2023

Gangliosides are sialylated glycolipids, mainly present at the cell surface membrane, involved in a variety of cellular signaling events. During malignant transformation, the composition of these glycosphingolipids is altered, leading to structural and functional changes, which are often negatively correlated to patient survival. Cancer cells have the ability to shed gangliosides into the tumor microenvironment, where they have a strong impact on anti-tumor immunity and promote tumor progression. Since most ganglioside species show prominent immunosuppressive activities, they might be considered checkpoint molecules released to counteract ongoing immunosurveillance. In this review, we highlight the current state-of-the-art on the ganglioside-mediated immunomodulation, specified for the different immune cells and individual gangliosides. In addition, we address the dual role that certain gangliosides play in the tumor microenvironment. Even though some ganglioside species have been more extensively studied than others, they are proven to contribute to the defense mechanisms of the tumor and should be regarded as promising therapeutic targets for inclusion in future immunotherapy regimens.
Microlearning through TikTok in Higher Education. An evaluation of uses and potentials
Authors: Conde-Caballero David , Castillo-Sarmiento Carlos A. , Ballesteros-Yánez Inmaculada , Rivero-Jiménez Borja , Mariano-Juárez Lorenzo
Published: June 2023

While social media is evolving rapidly, understanding its underlying and persistent features with the potential to support high-quality learning would provide opportunities to enhance competence acquisition and collaborative work in higher education. Moreover, the adoption of tools that students already use in their everyday lives facilitates the integration of new forms of learning. In this context, we have developed an initiative to disseminate content through TikTok in three modules of the Bachelor's Degree in Nursing course, with the aim of promoting quality learning through these microlearning environments. To this end, we have implemented these learning environments and evaluated the users’ perceptions, as well as their level of acceptance of the technology according to the Technology Acceptance Model. Overall, our results show high levels of satisfaction with regard to engagement and the content generated, as well as in terms of the acceptance of the technology. Our results do not show gender-specific variations, but we did detect slight variations depending on the subject in which the microlearning tool was deployed. Although for the most part these variations do not change the participants' assessment of their experience, it will be necessary in the future to determine the underlying reasons for these variations. In addition, our results suggest that it is possible to design a content creation system to promote quality learning through microlearning that can be transferred to other subjects, at least in the Bachelor's Degree in Nursing.
Temporal evolution of PM2.5, PM10, and total suspended particles (TSP) in the Ciuc basin (Transylvania) with specific microclimate condition from 2010 to 2019
Authors: Bodor Katalin , Szép Róbert , Keresztesi Ágnes , Bodor Zsolt
Published: June 2023

Modern societies are characterized by increased air pollution, and particulate matter (PM) is one of the most significant air pollutants and is a major environmental health problem. Therefore, long- and short-term exposure via inhalation, ingestion, and dermal absorption of particulate matter may cause series health issues, such as cardio pulmonary and lung cancer disease. Air pollutants accumulation is significantly higher in closed regions or basins characterized by strong thermal inversions, especially during the cold period such in case of the Ciuc basin. The aim of this study was to carry out the time series analysis of PM2.5, PM10 and TSP in the Ciuc basin for the period 2010–2019, in order to decipher the main characteristics of air pollution in this region.

The data obtained were analyzed on a daily, monthly and annual basis by different statistical methods. The average monthly concentration of TSP (60.03 µg m−3), PM10 (19.21 µg m−3) and PM2.5 (14.73 µg m−3) particulate matter in the studied regions varied between 29.84–134.79 µg m−3, 4.38–63.51 µg m−3 and 4.01–54.41 µg m−3, respectively. Regarding the ratio of PM2.5 and PM10 in the total particulate matter (TPM) was 0.25 and 0.33. Due to meteorological factors and emission fluctuations, particulate matter exhibits high seasonal variations, therefore the highest concentrations were recorded during the cold period, while the lowest values were observed in summer. The percentage of PM10 exceedances (50 µg m−3) represents 24.8% in winter, meanwhile in autumn and spring a significantly lower exceedances percentage was observed, 2.6% and 1.7%, respectively. The correlation analysis revealed that the correlation level of the studied pollutants varied between 0.73–0.78.
Potential benefit of microalgae and their interaction with bacteria to sustainable crop production
Authors: Solomon Wogene , Mutum Lamnganbi , Janda Tibor , Molnár Zoltán
Published: June 2023

Agriculture is undergoing a paradigm shift as it moves away from relying only on agrochemicals toward natural-based product to enhance plant growth and productivity while sustainably maintaining soil quality and productivity. In this sense, microalgae and bacteria offer a unique potential due to the growing use of novel and eco-friendly products such as biofertilizers, biostimulants, and biopesticides. Microalgae improve crop growth and health by fixing nitrogen, releasing soil trace elements, solubilizing potassium, and phosphorus, producing exopolysaccharides, and converting organic matter into utilizable nutrients. They also release bioactive substances including, carbohydrates, proteins, enzymes, vitamins, and hormones, to promote plant growth, control pests, and mitigate plant stress responses. Even though it has long been known that microalgae produce various bioactive and signaling molecules (like phytohormones, polysaccharides, lipids, carotenoids, phycobilins, and amino acids) which are effective in crop production, the targeted applications of these molecules in plant science are still in the very early stages of development. Microalgae are beneficial to bacteria because they produce oxygen and extracellular chemicals, and bacteria, in turn, provide microalgae with carbon dioxide, vitamins, and other nutrients in exchange. This review discusses the possible role of microalgae in increasing crop yield, protecting crops, and maintaining soil fertility and stability, and it points out that interactions of microalgae and bacteria may have a better enhancement of crop production in a sustainable way than using either of them alone.
How best to incorporate conjunctive water management into international water law: legal amendment, instrument coupling, or new protocol adoption?
Authors: Ibrahim Imad Antoine , Lautze Jonathan
Published: June 2023

International water conventions—e.g., the1997 United Nations Convention on the Non-Navigational Uses of International Watercourses—include positive but insufficient focus on groundwater and its interaction with surface water. As such, a growing body of literature has proposed modifications to existing frameworks to enable consideration to surface and groundwater and their interactions. While this literature places considerable focus on coupling and amending existing legal frameworks, elaboration and evaluation of a new protocol on conjunctive water management comprises a key gap. To fill this gap, this paper seeks to answer the following question: does formulation and adoption of anew“conjunctive” protocol provide more value than existing proposals centered around modifications toexistinglaw? This paper seeks to compare benefits associated with current proposals to strengthen the international legal framework for management of surface–groundwater interaction,vis-a-visadoption of a new protocol on conjunctive management of transboundary freshwaters. To do so, the authors use doctrinal legal methods to analyze the existing main instruments globally assessing the degree to which they consider key interlinkages between surface water and groundwater. Then, the paper examines the concept of conjunctive water management and deduces tenets that should be pursued in shared waters to achieve this objective. To identify the preferred option to support conjunctive water management in international water law, the paper explores the degree to which existing proposalsvsa new protocol enable an embrace of these tenets of conjunctive water management. The paper finds that while a new protocol may add greater value in advancing conjunctive water management, multiple options can and should be concurrently pursued. In particular, the authors argue that new protocols to the existing treaties must be adopted in combination with the amendment of the Draft Articles on the Law of Transboundary Aquifers. Benefits of doing so include more effective management of transboundary freshwater resources that are interconnected hydrologically, a less fragmented and more consistent international water regime, and ultimately more benefits accruing to the populations and environmental goods dependent on shared water resources.
Comparative analysis of signal accuracy of three SpO2 monitors during motion and low perfusion conditions
Authors: Giuliano Karen K , Bilkovski Robert N , Beard John , Lamminmäki Sakari
Published: June 2023

To compare pulse oximetry performance during simulated conditions of motion and low perfusion in three commercially available devices: GE HealthCare CARESCAPE ONE TruSignal SpO2 Parameter, Masimo RADICAL-7 and Medtronic Nellcor PM1000N. After IRB approval, 28 healthy adult volunteers were randomly assigned to the motion group (N = 14) or low perfusion (N = 14) group. Pulse oximeters were placed on the test and control hands using random assignment of digits 2–5. Each subject served as their own control through the series of repeated pair-wise measurements. Reference co-oximetry oxyhemoglobin (SaO2) measurements from the radial artery were also obtained in the motion group. SpO2 readings were compared between the test and control hands in both groups and to SaO2 measurements in the motion group. Accuracy was assessed through testing of accuracy root-mean squared (ARMS) and mean bias. In the simulated motion test group the overall Accuracy Root Mean Square (ARMS) versus SaO2 was 1.88 (GE), 1.79 (Masimo) and 2.40 (Nellcor), with overall mean bias of − 0.21 (Masimo), 0.45 (GE), and 0.78 (Nellcor). In the motion hand, ARMS versus SaO2 was 2.45 (GE), 3.19 (Masimo) and 4.15 (Nellcor), with overall mean bias of − 0.75 (Masimo), − 0.01 (GE), and 0.04 (Nellcor). In the low perfusion test group, ARMS versus the control hand SpO2 for low PI was 3.24 (GE), 3.48 (Nellcor) and 4.76 (Masimo), with overall bias measurements of − 0.53 (Nellcor), 0.96 (GE) and 1.76 (Masimo). Experimental results for all tested devices met pulse oximetry regulatory and testing standards requirements. Overall, SpO2 device performance across the three devices in this study was similar under both motion and low perfusion conditions. SpO2 measurement accuracy degraded for all three devices during motion as compared to non-motion. Accuracy also degraded during normal to low, very low, or ultra low perfusion and was more pronounced compared to the changes observed during simulated motion. While some statistically significant differences in individual measurements were found, the clinical relevance of these differences requires further study.
Quantifying physiological stability in the general ward using continuous vital signs monitoring: the circadian kernel density estimator
Authors: Rasmussen Søren S. , Grønbæk Katja K. , Mølgaard Jesper , Haahr-Raunkjær Camilla , Meyhoff Christian S. , Aasvang Eske K. , Sørensen Helge B. D.
Published: June 2023

Technological advances seen in recent years have introduced the possibility of changing the way hospitalized patients are monitored by abolishing the traditional track-and-trigger systems and implementing continuous monitoring using wearable biosensors. However, this new monitoring paradigm raise demand for novel ways of analyzing the data streams in real time. The aim of this study was to design a stability index using kernel density estimation (KDE) fitted to observations of physiological stability incorporating the patients’ circadian rhythm. Continuous vital sign data was obtained from two observational studies with 491 postoperative patients and 200 patients with acute exacerbation of chronic obstructive pulmonary disease. We defined physiological stability as the last 24 h prior to discharge. We evaluated the model against periods of eight hours prior to events defined either as severe adverse events (SAE) or as a total score in the early warning score (EWS) protocol of ≥ 6,  ≥ 8, or ≥ 10. The results found good discriminative properties between stable physiology and EWS-events (area under the receiver operating characteristics curve (AUROC): 0.772–0.993), but lower for the SAEs (AUROC: 0.594–0.611). The time of early warning for the EWS events were 2.8–5.5 h and 2.5 h for the SAEs. The results showed that for severe deviations in the vital signs, the circadian KDE model can alert multiple hours prior to deviations being noticed by the staff. Furthermore, the model shows good generalizability to another cohort and could be a simple way of continuously assessing patient deterioration in the general ward.
Integrating seascape resistances and gene flow to produce area-based metrics of functional connectivity for marine conservation planning
Authors: Wilcox Mark A. , Jeffery Nicholas W. , DiBacco Claudio , Bradbury Ian R. , Lowen Ben , Wang Zeliang , Beiko Robert G. , Stanley Ryan R. E.
Published: June 2023

Context

Prioritizing regions that facilitate connectivity among populations is an essential principle for conservation planning. However, the lack of conspicuous geographical and environmental features that constrain dispersal and gene flow throughout life history challenges the characterization of dispersal pathways within a three-dimensional marine realm.

Objectives

To elucidate regions of high connectivity value in the marine environment, we develop a novel approach that integrates estimates of spatial genetic structure with representation of regions of high dispersal potential for meroplankton, incorporating elements of pelagic larval and benthic adult life history.

Methods

Spatial patterns of connectivity were characterized using circuit theory as an inverse function oceanographic- and habitat-based resistance to movement. We integrate emergent spatial patterns of connectivity with population genetic data to account for realized patterns of gene flow across a seascape. We apply this approach to four broadly distributed species in the Northwest Atlantic.

Results

Estimates of resistance to gene flow revealed multiple connectivity barriers not observed in oceanographic or habitat models. Comparison of isolation-by-distance versus isolation-by-resistance revealed genetic variation was best explained by seascape resistance in three of four species, supporting the resistance-based assessments of connectivity. Our approach identified areas of high and low connectivity value for each species, with overlap generally associated with geographic pinch points and areas of low genetic exchange.

Conclusions

By integrating spatial interpolations of gene flow and estimated pathways for dispersal, we develop a novel area-based metric of connectivity that considers life-history based structural constraints to dispersal and observed genetic variation. Outputs from this workflow can reveal regions of connectivity for conservation planning.
Solving Geophysical Inversion Problems with Intractable Likelihoods: Linearized Gaussian Approximations Versus the Correlated Pseudo-marginal Method
Authors: Friedli Lea , Linde Niklas
Published: June 2023

A geophysical Bayesian inversion problem may target the posterior distribution of geological or hydrogeological parameters given geophysical data. To account for the scatter in the petrophysical relationship linking the target parameters to the geophysical properties, this study treats the intermediate geophysical properties as latent (unobservable) variables. To perform inversion in such a latent variable model, the intractable likelihood function of the (hydro)geological parameters given the geophysical data needs to be estimated. This can be achieved by approximation with a Gaussian probability density function based on local linearization of the geophysical forward operator, thereby, accounting for the noise in the petrophysical relationship by a corresponding addition to the data covariance matrix. The new approximate method is compared against the general correlated pseudo-marginal method, which estimates the likelihood by Monte Carlo averaging over samples of the latent variable. First, the performances of the two methods are tested on a synthetic test example, in which a multivariate Gaussian porosity field is inferred using crosshole ground-penetrating radar first-arrival travel times. For this example with rather small petrophysical uncertainty, the two methods provide near-identical estimates, while an inversion that ignores petrophysical uncertainty leads to biased estimates. The results of a sensitivity analysis are then used to suggest that the linearized Gaussian approach, while attractive due to its relative computational speed, suffers from a decreasing accuracy with increasing scatter in the petrophysical relationship. The computationally more expensive correlated pseudo-marginal method performs very well even for settings with high petrophysical uncertainty.
Face/Off: The adverse effects of increased competition
Authors: Ahmadi Iman
Published: June 2023

Increased competition can result in market efficiency. However, alternatively, it may provoke unethical behavior by sellers attempting to avoid losses—a risk that may be greater in credence goods markets, where consumers find it difficult to determine the value of goods or services received. The New York City (NYC) taxi market allows us to investigate how increased competition due to the launch of green-colored taxis (to serve only certain parts of NYC) may lead to fraudulent behavior by drivers of the established yellow taxis. An empirical study of more than 17 million matched yellow taxi trips revealed that fraudulent behavior was most prevalent on routes in which drivers faced increased competition for both pickups and post-drop-off pickups. However, after the launch of green taxis, there was no significant change in the trip distances of yellow taxis for rides subject to a flat-rate fare or for trips to/from office buildings where passengers were more familiar with optimal routes.
Pathological observation and transcriptomic analysis of thymus injury in PRRSV-infected piglets
Authors: Su Naying , Lin Zhengdan , Liu Xi , Sun Xiuxiu , Jin Xinxin , Feng Helong , Zhan Cunlin , Hu Xueying , Gu Changqin , Zhang Wanpo , Cheng Guofu
Published: June 2023

The thymus, the central immune organ in mammals, plays an important role in immune defense. Porcine reproductive and respiratory syndrome virus (PRRSV) infection in piglets can cause thymus injury and immunosuppression. However, the mechanisms of thymus injury remain unknown. This study was aimed at investigating the specific manifestations of thymus injury through the construction of a PRRSV-infected piglet model and histopathological observation. In this study, fourteen 40-day-old PRRSV-free piglets were randomly divided into two groups, eleven of which were intramuscularly injected with 3 mL of PRRSV WUH3 virus suspension (106 PFU /mL) in the infection group, and three of which were sham-inoculated with 3 mL of RPMI-1640 medium in the control group. Clinical necropsy and samples collection were performed on day 8 after artificial infection. With the Illumina platform, the transcriptomes of piglet thymus tissues from infected and control piglets were sequenced to explore the relationships of differentially expressed genes (DEGs) and signaling pathways with thymus injury. The immune organs of PRRSV-infected piglets were severely damaged. The histopathological findings in the thymus indicated that PRRSV infection was associated with a large decrease in lymphocytes, cell necrosis and cell apoptosis; an increase in blood vessels and macrophages; thymic corpuscle hyperplasia; and interstitial widening of the thymic lobules. The transcriptomic analysis results revealed that the Gene Ontology functions of DEGs were enriched primarily in biological processes such as angiogenesis, regulation of angiogenesis and positive regulation of cell migration. Moreover, greater numbers of blood vessels and macrophages were observed in the thymus in PRRSV-infected than control piglets. KEGG pathway enrichment analysis revealed that the DEGs were significantly enriched in the Toll-like receptor signaling pathway, chemokine signaling pathway, IL-17 signaling pathway and TNF signaling pathway. The expression of TLR8, IRF5, the chemokines CCL2, CCL3L1 and CCL5; and their receptors CCR1, CCR2 and CCR5 was significantly up-regulated in PRRSV infection, thus suggesting that these cytokines were associated with the pathological processes of thymus injury.
Nucleation and Growth Dynamics of Equiaxed Dendrites in Thin Metallic Al–Cu and Al–Ge Samples in Microgravity and on Earth
Authors: Becker Maike , Wegener Mareike , Drescher Jörg , Kargl Florian
Published: June 2023

In this study, the nucleation and growth characteristics of equiaxed dendrites in near-isothermal solidification experiments, performed during two sounding rocket missions, MAPHEUS-6 and 7, are investigated. Two samples of the composition Al–15 wt pct Cu and one sample of the composition Al–46 wt pct Ge were processed in microgravity and several samples on ground. In situ X-radiography was performed to observe the nucleation dynamics and microstructure evolution during solidification of the 200 µm thin, disc-shaped samples. The measured dendritic growth rates and observed concentration distributions in the liquid indicate no difference between microgravity and on-ground horizontal experiments, in line with previous observations. On the contrary, a difference in the nucleation behavior was found. In all microgravity experiments bursts of nucleation were observed, which is different from comparable on-ground solidification experiments, where the nucleation occurs continuously. The combined analyses suggest that small variations of the concentration fields that probably originate from convective flow and buoyancy of the grains in the on-ground experiments, lead to a spatially variable nucleation undercooling distribution and hence to continuous nucleation. In contrast, the absence of convective flow in microgravity results in a more uniform nucleation undercooling distribution. The grains therefore nucleate in bursts at the surface walls, when the necessary nucleation undercooling is reached.
Supporting One Health for Pandemic Prevention: The Need for Ethical Innovation
Authors: Diller Elena R. , Williamson Laura
Published: June 2023

Bioethics is a field in which innovation is required to help prevent and respond to zoonotic diseases with the potential to cause epidemics and pandemics. Some of the developments necessary to fight pandemics, such as COVID-19 vaccines, require public debate on the benefits and risks of individual choice versus responsibility to society. While these debates are necessary, a more fundamental ethical innovation to rebalance human, animal, and environmental interests is also needed. One Health (OH) can be characterized as a strategy that recognizes and promotes the synergy between human, animal, and environmental health. Yet, despite the recognition that these entities are interdependent, there is a pronounced inequality in the power relations between human, non-human animal, and the environmental interests which threatens the well-being of all. Until OH can ensure the moral status of animals and the environment and thereby the equal consideration of these interests, it will struggle to protect non-human interests and, as a result, human health. To create a sustainable health system requires a renewed concept of justice that is ecocentric in nature and an application of OH that is flexible and responsive to different ethical interests (e.g., person-centred care and physician responsibilities). Ultimately, to save themselves, humans must now think beyond themselves. Bioethics must assume a key role in supporting the developments required to create and maintain relationships able to sustain environmental and human health.
Mathematics education research on language and on communication including some distinctions: Where are we now?
Authors: Planas Núria , Pimm David
Published: June 2023

In this article, we present a narrative review of mathematics education research on language and on communication over 2019–2022, but also look ahead by addressing challenges posed by the lack of distinction between language and communication. The persistence and significance of the problem of the distinction between language and communication are thus outlined in a historical moment of celebration of growth of research in the domain. Informed by the analysis of a selection of research journal articles and by our trajectories, we discuss influential topics in the recent discourse: multilingual mathematics classrooms; mathematics teacher education on language in mathematics teaching; multimodal mathematical communication; interaction and mathematics learning; mathematical language and discourse. We connect this with new emerging or old revisited concepts: instructional designing, gesturing, argumenting and languaging. We finish by further reflecting on multimodal mathematical communication and gesturing, and on the potential of expanding the notion of mathematics register towards a notion of mathematics communication register.
The role of CU traits, empathy and moral disengagement in bullying
Authors: Eilts Jule , Bäker Neele
Published: June 2023

Bullying and victimization have been of interest to a wide variety of disciplines for years due to their serious consequences (Zych et al., 2019). The focus has primarily been on personality factors which have significant associations with bullying perpetration. These factors include CU traits, empathy, and moral disengagement (e.g., Gini, 2006; Thornberg et al., 2015; Zych et al., 2019). However, the relation between those constructs and bullying perpetrator behaviors are unclear and have not been integrated in a single study. Additionally, studies suggest that students with special education support needs are overrepresented in bullying dynamics (e.g., Hartley et al., 2015). Therefore, the objective of this study was to examine whether moral disengagement and empathy act as mediators of CU traits on bullying perpetrator behavior while controlling age, gender and special educational needs. The sample consists of 201 students (Mage = 12.85; SD = 1.37) which were enrolled in schools in Germany. High CU traits were associated with low cognitive and affective empathy and high moral disengagement. Additionally, special educational needs were associated with higher moral disengagement. Moral disengagement mediates the relationship between CU traits and bullying. These findings expand the knowledge of influencing factors in the bullying dynamic and have significant implications for prevention and intervention practices.
Some Remarks on Petty Projection of Log-concave Functions
Authors: da Silva Letícia Alves , Merino Bernardo González , Villa Rafael
Published: June 2023

In this note we study the Petty projection of a log-concave function, which has been recently introduced in [9]. The aim of this note is to report a mistake in Theorem 5.2 of [9] and to give correct new inequalities involving this new notion.
Profile defects caused by inhomogeneous longitudinal strain distribution in roll forming
Authors: Kilz J. , Güngör B. , Aign F. , Groche P.
Published: June 2023

Roll
forming is a sheet metal forming operation that incrementally forms flat sheets into a desired profile geometry. The process is characterized by a high material utilization and a high output quantity. Concomitant with these advantages, profile defects such as bow and twist of the profile can occur. In the literature, an inhomogeneous longitudinal strain distribution across the profile cross-section is considered to be the cause of these defects. However, a quantitative cause and effect analysis is missing up to now. This paper presents an analytical model that shows a quantitative relationship between profile defects and the underlying longitudinal strain distributions. The model can be used to calculate the longitudinal strain distribution of a roll-formed profile across its cross-section based on given values for bow and twist or vice versa. It is compared with results from simulations and experiments and clearly reveals the cause for twist and bow in roll forming.

Graphical abstract
Exploring design elements of personal data markets
Authors: Scheider Simon , Lauf Florian , Geller Simon , Möller Frederik , Otto Boris
Published: June 2023

Since the emerging information economy relies heavily on data for advancement and growth, data markets have gained increasing attention. However, while global data economies are evolving and data are increasingly shared among organizations in various data ecosystems, marketplaces for personal data (PDMs) exhibited considerable start-up difficulties, which doomed their majority to either fail quickly or to operate in legal grey zones. Apparently, in recent times, novel PDMs have arisen which seem economically and technically viable. The study investigates this “new generation” from both an economic and a technological perspective. Adhering to a rigorous methodology for taxonomy building and evaluation, 18 dimensions and 59 characteristics are presented alongside which these new PDMs can be designed. Additionally, archetypes are derived. The findings reveal that PDMs tend to follow certain design commonalities holding for data markets generally but comprise specific design elements distinguishing them both from conventional data markets and among each other.
Age Assignment, Palaeoecology and Sequence Stratigraphic Framework of the Nukhul Formation at Wadi Baba, West-Central Sinai (Egypt)
Authors: Abu Shama Aziz , El-Nahrawy Sara , Farouk Sherif
Published: June 2023

The Nukhul Formation has been a point of controversy until now due to a lack of index fossils, varied facies modifications, and different time gaps. As a result, the calcareous nannofossils of the exposed Miocene rocks at Wadi Baba, west-central Sinai have been studied quantitatively for the first time. An important sequence of calcareous nannofossil bioevents has been recorded in the Nukhul Formation, including the FOs ofDiscoaster druggii,Sphenolithus dissimilis,Helicosphaera ampilaperta,andSphenolithus disbelemnos,which correspond to the Aquitanian age of upper NN1 and NN2 zones. The Nukhul Formation contains four intervals that reflect eutrophic conditions in the nearshore habitats with substantial nutrient input from the terrigenous influx, as shown by the dominance of cool-water taxa,Coccoliths pelagicusandReticulofenestra minuta. The lithofacies, microfacies types, abundance, dominance, and diversity of nannofossil assemblages classified the studied interval into two depositional sequences with four system tracts. These tracts refer to fluctuations in relative sea level changes in response to the eustatic sea-level curve.
Caregivers’ Burden in Parkinson’s Disease: A Study on Related Features and Attachment Styles
Authors: Carpinelli Luna , Savarese Giulia , Russo Claudio , Stornaiuolo Giovanna , Luisi Ettore , Pellegrino Francesca , Mollo Monica , Pellecchia Maria Teresa
Published: June 2023

Parkinson’s disease (PD) is a chronic progressive neurological disease clinically characterized by motor and non-motor symptoms, with an increasing impact on the quality of life not only for the patient but also for the caregivers. Twenty-six primary caregivers (female = 19; mean age = 57.04, SD = 10.64) of PD patients were consecutively recruited. Several psychological aspects were verified through clinical screening tests: EQ-5D and PQoL CARER for quality of life, Hospital Anxiety and Depression Scale (HADS), Caregiver Burden Inventory (CBI), Family Strain Questionnaire (FSQ), and Adult Attachment Questionnaire. We found that the burden was generally higher in cohabiting female caregivers of patients with dementia as compared with not cohabiting caregivers. Severe burden emerged in 7.7% of the participants according to the PQoL. The mean score of this scale was higher in cohabiting caregivers. Finally, according to the CBI, 19.2% of the participants suffered from severe burden, with mean scores of the CIB-S and CIB-E subscales higher in cohabitants. Our study highlights the need to investigate more thoroughly the burden of caregivers of PD patients and its associated factors, and to pay more attention to the physical and psychological health of caregivers to improve their quality of life.
Predicting consumers’ intention towards entomophagy using an extended theory of planned behavior: evidence from Myanmar
Authors: Thu Thu Aung Myint , Dürr Jochen , Klink-Lehmann Jeanette , Borgemeister Christian
Published: June 2023

The concept of entomophagy—consuming insects as food—has become particularly important from the perspective of food security. Myanmar is an entomophagous country, but where chronic malnutrition problems persist. A lack of research into the topic of entomophagy in Myanmar makes it difficult to understand people's behavior regarding edible insects as food, as well as their motives and aversions. As this knowledge gap emphasizes the need for consumer studies of edible insects in Myanmar, this study examines the factors affecting consumers’ intention to eat insects. The model used is based on the theory of planned behavior, extended by the variable environmental concern. Data collection was conducted through telephone interviews, acquiring 872 respondents. Structural equation modelling analysis was performed to predict the influence factors on consumption intention towards edible insects. Results revealed that participants’ consumption intention was low and primarily influenced by attitude, subjective norm, perceived behavioral control, and environmental concern. Only four out of ten factors had moderating effects on consumption intention, mainly the administrative division, urban or rural location, educational level and ethnic groups. These results are useful for further developing the insect sector in Myanmar, and especially for creating more public awareness of the benefits of eating insects as well as promoting a more positive attitude and possibly leading to an increase in consumption intention. A gradual shift from mere collection to insect farming would improve all year availability of edible insects and reduce the difficulties of consumers accessing edible insects. Consequently, edible insects can assist in achieving the nutrition policy's objective of reducing all types of malnutrition by making it easier for all people, at all times of the year, to acquire nutritious food at an affordable price.
Late-Georgian Churches
Authors: Webster Christopher
Published: June 2023

How the Anglican church responded to population growth and the need for more accommodation, with the building of 1500 new churches, many of the finest quality.
Goethe Yearbook 21
Authors: Allingham Liesl , Carter William H. , Vandegrift Eldridge Sarah , Lyon John B. , Maierhofer Waltraud , Minter Catherine , Mommsen Katharina , Pan David , Saman Michael , Weatherby Leif , Wellbery David E.
Published: June 2023

The Goethe Yearbook is a publication of the Goethe Society of North America, encouraging North American Goethe scholarship by publishing original English-language contributions to the understanding of Goethe and other authors of the Goethezeit while also welcoming contributions from scholars around the world. Volume 21 contains eleven articles, including contributions by leading scholars David Wellbery and Katharina Mommsen; innovative work on the reception of Goethe's works around 1900, on women writers, and on Goethe's contemporary Albrecht von Haller; theoretically sophisticated interpretations, including articles on concepts of space in Alexis and Doraand on notions of sacrifice in Faust; and interdisciplinary pieces ranging from a discussion of contemporary psychological and medical theories of ill humor in relation to Goethe's Werther and an economic reading of Goethe's Faust to an analysis of illustrations of Goethe's works. The review section collects responses by eminent scholars to a wide swath of recent books on Goethe and his age, both in German and English. Contributors: Liesl Allingham, William H. Carter, Sarah Vandegrift Eldridge, John B. Lyon, Waltraud Maierhofer, Catherine Minter, Katharina Mommsen, David Pan, Michael Saman, Leif Weatherby, David E. Wellbery. Adrian Daub is Associate Professor of German at Stanford. Elisabeth Krimmer is Professor of German at the University of California Davis. Book review editor Birgit Tautz is Associate Professor of German at Bowdoin College.
Pride of Peacocks
Authors: Lazenby Keith , Moore-Colyer Richard
Published: June 2023

This memoir provides a glimpse into the well-known and long-standing local Bedford company of W. & H. Peacock during the years 1902-1988.