bluuebunny/crossref_metadata_2025 huggingface dataset:
The Attempt on the Seven Londoners
Authors: Downs Jordan
Published: August 2020

Historians of the English Revolution are well aware of the infamous events of 4 January 1642, when Charles I tried to arrest one peer and five Members of Parliament on charges of treason. The failed plan, later known as ‘the attempt on the Five Members’, led to an uproar in both Houses of Parliament and days of rioting in London that drove the king and his family to flee for their safety under the cover of night. Scholars are, however, less aware—perhaps even entirely unaware—of the events of January 1643, exactly one year later, when the king made a fateful attempt to arrest seven politically active Londoners for treason: Isaac Pennington, John Fowke, John Venn, Randall Mainwaring, Richard Browne, Edmund Harvey and Robert Tichborne. This article looks closely at the politics surrounding the king’s ‘second mistake’, and the ways in which City militants and the war party in Parliament manipulated events surrounding the affair in order to escalate the conflict. Much more than simply suggesting that Charles I was at best incorrigible, a king incapable of learning from his mistakes, the attempt on the seven Londoners reveals the significance of the struggle for popular mobilisation in the war-torn metropolis, and indeed the degree to which London had, by early 1643, become a cornerstone of Parliament’s war effort.
The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: the BAMI trial
Authors: Mathur Anthony , Fernández-Avilés Francisco , Bartunek Jozef , Belmans Ann , Crea Filippo , Dowlut Sheik , Galiñanes Manuel , Good Marie-Claire , Hartikainen Juha , Hauskeller Christine , Janssens Stefan , Kala Petr , Kastrup Jens , Martin John , Menasché Philippe , Sanz-Ruiz Ricardo , Ylä-Herttuala Seppo , Zeiher Andreas ,   On behalf of the BAMI Group
Published: August 2020

Aims 

Bone marrow-derived mononuclear cell (BM-MNC) therapy may improve myocardial recovery in patients following acute myocardial infarction (AMI), though existing trial results are inconsistent.

Methods and results 

Originally an open-label, multicentre Phase III trial, BAMI was designed to demonstrate the safety and efficacy of intracoronary infusion of BM-MNCs in reducing the time to all-cause mortality in patients with reduced left ventricular ejection fraction (LVEF, ≤45%) after primary angioplasty (PPCI) for ST-elevation AMI. Unexpectedly low recruitment means the trial no longer qualifies as a hypothesis-testing trial, but is instead an observational study with no definitive conclusions possible from statistical analysis. In total, 375 patients were recruited: 185 patients were randomized to the treatment arm (intracoronary infusion of BM-MNCs 2–8 days after PPCI) and 190 patients to the control arm (optimal medical therapy). All-cause mortality at 2 years was 3.26% [6 deaths; 95% confidence interval (CI): 1.48–7.12%] in the BM-MNC group and 3.82% (7 deaths; 95% CI: 1.84–7.84%) in the control group. Five patients (2.7%, 95% CI: 1.0–5.9%) in the BM-MNC group and 15 patients (8.1%, CI : 4.7–12.5%) in the control group were hospitalized for heart failure during 2 years of follow-up. Neither adverse events nor serious adverse events differed between the two groups. There were no patients hospitalized for stroke in the control group and 4 (2.2%) patients hospitalized for stroke in the BM-MNC group.

Conclusions 

Although BAMI is the largest trial of autologous cell-based therapy in the treatment of AMI, unexpectedly low recruitment and event rates preclude any meaningful group comparisons and interpretation of the observed results.
Catheter ablation vs. thoracoscopic surgical ablation in long-standing persistent atrial fibrillation: CASA-AF randomized controlled trial
Authors: Haldar Shouvik , Khan Habib Rehman , Boyalla Vennela , Kralj-Hans Ines , Jones Simon , Lord Joanne , Onyimadu Oluchukwu , Satishkumar Anitha , Bahrami Toufan , De Souza Anthony , Clague Jonathan R , Francis Darrel P , Hussain Wajid , Jarman Julian W , Jones David Gareth , Chen Zhong , Mediratta Neeraj , Hyde Jonathan , Lewis Michael , Mohiaddin Raad , Salukhe Tushar V , Murphy Caroline , Kelly Joanna , Khattar Rajdeep S , Toff William D , Markides Vias , McCready James , Gupta Dhiraj , Wong Tom
Published: August 2020

Aims 

Long-standing persistent atrial fibrillation (LSPAF) is challenging to treat with suboptimal catheter ablation (CA) outcomes. Thoracoscopic surgical ablation (SA) has shown promising efficacy in atrial fibrillation (AF). This multicentre randomized controlled trial tested whether SA was superior to CA as the first interventional strategy in de novo LSPAF.

Methods and results 

We randomized 120 LSPAF patients to SA or CA. All patients underwent predetermined lesion sets and implantable loop recorder insertion. Primary outcome was single procedure freedom from AF/atrial tachycardia (AT) ≥30 s without anti-arrhythmic drugs at 12 months. Secondary outcomes included clinical success (≥75% reduction in AF/AT burden); procedure-related serious adverse events; changes in patients’ symptoms and quality-of-life scores; and cost-effectiveness. At 12 months, freedom from AF/AT was recorded in 26% (14/54) of patients in SA vs. 28% (17/60) in the CA group [OR 1.128, 95% CI (0.46–2.83), P = 0.83]. Reduction in AF/AT burden ≥75% was recorded in 67% (36/54) vs. 77% (46/60) [OR 1.13, 95% CI (0.67–4.08), P = 0.3] in SA and CA groups, respectively. Procedure-related serious adverse events within 30 days of intervention were reported in 15% (8/55) of patients in SA vs. 10% (6/60) in CA, P = 0.46. One death was reported after SA. Improvements in AF symptoms were greater following CA. Over 12 months, SA was more expensive and provided fewer quality-adjusted life-years (QALYs) compared with CA (0.78 vs. 0.85, P = 0.02).

Conclusion 

Single procedure thoracoscopic SA is not superior to CA in treating LSPAF. Catheter ablation provided greater improvements in symptoms and accrued significantly more QALYs during follow-up than SA.

Clinical Trial Registration

ISRCTN18250790 and ClinicalTrials.gov: NCT02755688
Ticagrelor alone vs. ticagrelor plus aspirin following percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes: TWILIGHT-ACS
Authors: Baber Usman , Dangas George , Angiolillo Dominick Joseph , Cohen David Joel , Sharma Samin Kumar , Nicolas Johny , Briguori Carlo , Cha Jin Yu , Collier Timothy , Dudek Dariusz , Džavik Vladimir , Escaned Javier , Gil Robert , Gurbel Paul , Hamm Christian W , Henry Timothy , Huber Kurt , Kastrati Adnan , Kaul Upendra , Kornowski Ran , Krucoff Mitchell , Kunadian Vijay , Marx Steven Owen , Mehta Shamir , Moliterno David , Ohman Erik Magnus , Oldroyd Keith , Sardella Gennaro , Sartori Samantha , Shlofmitz Richard , Steg Philippe Gabriel , Weisz Giora , Witzenbichler Bernhard , Han Ya-Ling , Pocock Stuart , Gibson Charles Michael , Mehran Roxana
Published: August 2020

Aims 

The aim of this study was to determine the effect of ticagrelor monotherapy on clinically relevant bleeding and major ischaemic events in relation to clinical presentation with and without non-ST elevation acute coronary syndromes (NSTE-ACS) among patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES).

Methods and results 

We conducted a pre-specified subgroup analysis of The Ticagrelor With Aspirin or Alone in High Risk Patients After Coronary Intervention (TWILIGHT) trial, which enrolled 9006 patients with high-risk features undergoing PCI with DES. After 3 months of dual antiplatelet therapy (DAPT) with ticagrelor plus aspirin, 7119 adherent and event-free patients were randomized in a double-blind manner to ticagrelor plus placebo versus ticagrelor plus aspirin for 12 months. The primary outcome was Bleeding Academic Research Consortium (BARC) type 2, 3, or 5 bleeding while the composite of all-cause death, myocardial infarction (MI), or stroke was the key secondary outcome. Among patients with NSTE-ACS (n = 4614), ticagrelor monotherapy reduced BARC 2, 3, or 5 bleeding by 53% [3.6% vs. 7.6%; hazard ratio (HR) 0.47; 95% confidence interval (CI) 0.36–0.61; P < 0.001) and in stable patients (n = 2503) by 24% (4.8% vs. 6.2%; HR 0.76; 95% CI 0.54–1.06; P = 0.11; nominal P  int = 0.03). Rates of all-cause death, MI, or stroke among those with (4.3% vs. 4.4%; HR 0.97; 95% CI 0.74–1.28; P = 0.84) and without (3.1% vs. 3.2%; HR 0.96; 95% CI 0.61–1.49; P = 0.85) NSTE-ACS were similar between treatment arms irrespective of clinical presentation (P  int = 0.96).

Conclusion 

Among patients with or without NSTE-ACS who have completed an initial 3-month course of DAPT following PCI with DES, ticagrelor monotherapy reduced clinically meaningful bleeding events without increasing ischaemic risk as compared with ticagrelor plus aspirin. The benefits of ticagrelor monotherapy with respect to bleeding events were more pronounced in patients with NSTE-ACS.

Trial registration

Clinicaltrials.gov identifier: NCT02270242.
Complications in pulmonary vein isolation in the Netherlands Heart Registration differ with sex and ablation technique
Authors: Mol Daniel , Houterman Saskia , Balt Jippe C , Bhagwandien Rohit E , Blaauw Yuri , Delnoy Peter-Paul H , van Driel Vincent J , Driessen Antoine H , Folkeringa Richard J , Hassink Rutger J , van Huysduynen Bart Hooft , Luermans Justin G , Ouss Alexandre J , Stevenhagen Yorick J , van Veghel Dennis , Westra Sjoerd W , de Jong Jonas S , de Groot Joris R ,   the Netherlands Heart Registration Ablation Registration Committee
Published: August 2020

Aims 

Pulmonary vein isolation (PVI) has become a cornerstone of the invasive treatment of atrial fibrillation. Severe complications are reported in 1–3% of patients. This study aims to compare complications and follow-up outcome of PVI in patients with atrial fibrillation.

Methods and results 

The data were extracted from the Netherlands Heart Registration. Procedural and follow-up outcomes in patients treated with conventional radiofrequency (C-RF), multielectrode phased RF (Ph-RF), or cryoballoon (CB) ablation from 2012 to 2017 were compared. Subgroup analysis was performed to identify variables associated with complications and repeat ablations. In total, 13 823 patients (69% male) were included. The reported complication incidence was 3.6%. Patients treated with C-RF developed more cardiac tamponades (C-RF 0.8% vs. Ph-RF 0.3% vs. CB 0.3%, P ≤ 0.001) and vascular complications (C-RF 1.7% vs. Ph-RF 1.2% vs. CB 1.3%, P ≤ 0.001). Ph-RF was associated with fewer bleeding complications (C-RF: 1.0% vs. Ph-RF: 0.4% vs. CB: 0.7%, P = 0.020). Phrenic nerve palsy mainly occurred in patients treated with CB (C-RF: 0.1% vs. Ph-RF: 0.2% vs. CB: 1.5%, P ≤ 0.001). In total, 18.4% of patients were referred for repeat ablation within 1 year. Female sex, age, and CHA2DS2-VASc were independent risk factors for cardiac tamponade and bleeding complications, with an adjusted OR for female patients of 2.97 (95% CI 1.98–4.45) and 2.02 (95% CI 1.03–4.00) respectively.

Conclusion 

The reported complication rate during PVI was low. Patients treated with C-RF ablation were more likely to develop cardiac tamponades and vascular complications. Female sex was associated with more cardiac tamponade and bleeding complications.
Loneliness and Mental Health During the COVID-19 Pandemic: A Study Among Dutch Older Adults
Authors: van Tilburg Theo G , Steinmetz Stephanie , Stolte Elske , van der Roest Henriëtte , de Vries Daniel H
Published: August 2020

Objectives

With the spread of COVID-19, the Netherlands implemented a policy to keep citizens physically distanced. We hypothesize that consequent reduction in the frequency of social contacts, personal losses, and the experience of general threats in society reduced well-being.

Methods

Data were collected from 1,679 Dutch community-dwelling participants aged 65–102 years comprising a longitudinal online panel. Social and emotional loneliness and mental health were measured in May 2020, that is, 2 months after the implementation of the measures, and earlier in October and November 2019.

Results

In this pandemic, the loneliness of older people increased, but mental health remained roughly stable. The policy measures for physical distancing did not cause much social isolation but personal losses, worries about the pandemic, and a decline in trust in societal institutions were associated with increased mental health problems and especially emotional loneliness.

Discussion

The consequences of long-term social isolation and well-being must be closely monitored.
Brave New Lungs: Aging in the Shadow of COVID-19
Authors: Nowakowski Alexandra C H
Published: August 2020

As the COVID-19 pandemic continues to affect communities worldwide, this novel disease is leaving many survivors with severe lung damage. Among older patients, advanced lung damage is more likely. Survivors of all ages who have extensive lung impacts are likely to be new to managing those issues. Supporting healthy aging for these patients will require both gathering data about their unique experiences and using the existing evidence basis about adapting to managing obstructive lung disease. This article outlines key priorities for research with COVID-19 survivors aging with permanent lung damage and highlights unique considerations for people older at age of onset. It also outlines the relevance of findings from this research for clinical care supporting people newly aging with advanced lung disease from COVID-19. In the process, it summarizes lessons from established patient populations aging with progressive lung disease—using cystic fibrosis as a prominent example from the author’s lived experience—that may enhance the experiences of older COVID-19 survivors.
Pervasive Risk Avoidance: Nursing Staff Perceptions of Risk in Person-Centered Care Delivery
Authors: Behrens Liza L , Boltz Marie , Kolanowski Ann , Sciegaj Mark , Madrigal Caroline , Abbott Katherine , Van Haitsma Kimberly
Published: August 2020

Background and Objectives

Nursing home (NH) staff perceptions of risks to residents’ health and safety are a major barrier to honoring resident preferences, the cornerstone of person-centered care (PCC) delivery. This study explored direct-care nursing staff perceptions of risk (possibilities for harm or loss) associated with honoring residents’ preferences for everyday living and care activities.

Research Design and Methods

Qualitative, descriptive design using sequential focus group (FG) methodology.

Results

Participants (N = 27) were mostly female (85%), had more than 3 years of experience (74%), and worked in NHs recently experiencing 6–12 health citations. Content analysis of 12 sequential FGs indicated nursing staff perceptions of risks may impede delivery of person-centered care. This is supported by the overarching theme: pervasive risk avoidance; and subthemes of: staff values, supports for risk-taking, and challenges to honoring preferences.

Discussion and Implications

Development of a multidimensional framework with specific risk engagement measures that account for the unique risk perspectives of nursing staff will contribute significantly to the clinical management of older adult preferences and research on the effectiveness of preference-based PCC delivery in the NH setting.
Directionality of ambient noise in the Mississippi embayment
Authors: Liu Chunyu , Aslam Khurram , Langston Charles A
Published: August 2020

Cross-correlations of ambient seismic noise from 277 broad-band stations within the Mississippi embayment (ME) with at least 1 month of recording time between 1990 and 2018 are used to estimate source locations of primary and secondary microseisms. We investigate source locations by analysing the azimuthal distribution of the signal-to-noise ratios (SNRs) and positive/negative amplitude differences. We use 84 stations with 1 yr of continuous recordings to explore seasonal variations of SNRs and amplitude differences. We also investigate the seasonal ambient noise ground motions using 2-D frequency–wavenumber (FK) analysis of a 50-station array. We observe that: (1) two major azimuths can be identified in the azimuthal distribution of SNRs and amplitude differences. We also observe two minor azimuths in the seasonal variation of SNRs, amplitude differences and 2-D FK power spectra. Monthly 2-D FK power spectra reveal that two energy sources are active in the Northern Hemisphere winter and two relatively weak sources are active in summer. (2) Backprojection suggests that primary microseisms originate along the coasts of Australia or New Zealand, Canada and Alaska, Newfoundland or Greenland and South America. (3) Secondary microseisms are generated in the deep water of the northern and southern Pacific Ocean, along the coasts of Canada and Alaska associated with near-shore reflections and in the deep water of south of Greenland. (4) Weak energy is observed in the third quadrant of the azimuthal distribution of amplitude differences of sedimentary Rayleigh and Love waves in the period band of 1–5 s and correlates with the direction of widening of the basin.
Sparse isotope labeling for nuclear magnetic resonance (NMR) of glycoproteins using 13C-glucose
Authors: Rogals Monique J , Yang Jeong-Yeh , Williams Robert V , Moremen Kelley W , Amster I Jonathan , Prestegard James H
Published: August 2020

Preparation of samples for nuclear magnetic resonance (NMR) characterization of larger proteins requires enrichment with less abundant, NMR-active, isotopes such as 13C and 15N. This is routine for proteins that can be expressed in bacterial culture where low-cost isotopically enriched metabolic substrates can be used. However, it can be expensive for glycosylated proteins expressed in mammalian culture where more costly isotopically enriched amino acids are usually used. We describe a simple, relatively inexpensive procedure in which standard commercial media is supplemented with 13C-enriched glucose to achieve labeling of all glycans plus all alanines of the N-terminal domain of the highly glycosylated protein, CEACAM1. We demonstrate an ability to detect partially occupied N-glycan sites, sites less susceptible to processing by an endoglycosidase, and some unexpected truncation of the amino acid sequence. The labeling of both the protein (through alanines) and the glycans in a single culture requiring no additional technical expertise past standard mammalian expression requirements is anticipated to have several applications, including structural and functional screening of the many glycosylated proteins important to human health.
Emerging Patterns in the Judicial Determination of FRAND Rates: Comparable Agreements and the Top-Down Approach for FRAND Royalties Determination
Authors: Tsilikas Haris
Published: August 2020

The massive adoption of wireless technologies over the past decades has also brought about disputes regarding the interpretation of FRAND in the context of actual commercial relations. Courts in several jurisdictions worldwide ‒ in the EU, the US, China, India and Korea, among others ‒ have been called upon to flesh out FRAND terms or to assess conformity with FRAND principles. This body of case law provides rich insights into the workings of the markets for standards, but also practical guidance for parties as well as policymakers seeking a better understanding of the situation ‒ business and legal ‒ on the ground. The present article outlines some of the emerging patterns in SEP litigation worldwide, focusing on the judicial determination of FRAND rates. The common thread across jurisdictions regarding FRAND-rate determination is reliance on evidence and data in comparable licensing agreements. It is argued that comparable licensing agreements, i.e. licensing agreements signed with similarly situated parties, provide for the most reliable evidence on how markets price standardised technologies and SEPs.
Health-enhancing foods: barriers to consumers’ choice in Iran
Authors: Bazhan Marjan , Kalantari Naser , Keshavarz-Mohammadi Nastaran
Published: August 2020

Given the growing market for health-enhancing or functional foods in Iran, the consumption rate is low. Identifying and understanding the causes is key for future decisions and interventions in the market. So, the present study was designed to provide this knowledge in Iran. The study was conducted in Tehran, the capital of Iran, between May and September 2014. In total, 105 people participated in this qualitative research, including 40 production/supply/health authority stakeholders and 65 consumer stakeholders (44 housewives and 21 employed women). The sampling strategy was the purposive method with maximum diversity, and snowball sampling was used to identify key stakeholders. The social marketing framework was used for analyzing the participants’ views and experiences. To collect data, semi-structured focus group discussions and in-depth interviews were conducted. Data collection and content analysis were performed simultaneously, using MAXQDA® software. Categorization of the findings based on social marketing mix showed that the most important barriers to the consumption of functional dairy products were undesirable sensory and non-sensory characteristics, lack of physical and economic access to the product, the existence of product competitors in the market and inappropriate promotion strategies. Furthermore, personal barriers identified as a new dimension and included lack of knowledge about the product and its benefits, a negative attitude toward the product and personal taste and preference. Understanding these barriers might contribute to design and implement effective and appropriate interventions to increase the consumption of these products among consumers.
The phenomenal epigenome in neurodevelopmental disorders
Authors: Ciptasari Ummi , van Bokhoven Hans
Published: August 2020

Disruption of chromatin structure due to epimutations is a leading genetic etiology of neurodevelopmental disorders, collectively known as chromatinopathies. We show that there is an increasing level of convergence from the high diversity of genes that are affected by mutations to the molecular networks and pathways involving the respective proteins, the disrupted cellular and subcellular processes, and their consequence for higher order cellular network function. This convergence is ultimately reflected by specific phenotypic features shared across the various chromatinopathies. Based on these observations, we propose that the commonly disrupted molecular and cellular anomalies might provide a rational target for the development of symptomatic interventions for defined groups of genetically distinct neurodevelopmental disorders.
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases
Authors: Fowler Alan J , Hebron Michaeline , Balaraman Kaluvu , Shi Wangke , Missner Alexander A , Greenzaid Jonathan D , Chiu Timothy L , Ullman Clementina , Weatherdon Ethan , Duka Val , Torres-Yaghi Yasar , Pagan Fernando L , Liu Xiaoguang , Ressom Habtom , Ahn Jaeil , Wolf Christian , Moussa Charbel
Published: August 2020

The role of Discoidin Domain Receptors (DDRs) is poorly understood in neurodegeneration. DDRs are upregulated in Alzheimer’s and Parkinson’s disease (PD), and DDRs knockdown reduces neurotoxic protein levels. Here we show that potent and preferential DDR1 inhibitors reduce neurotoxic protein levels in vitro and in vivo. Partial or complete deletion or inhibition of DDR1 in a mouse model challenged with α-synuclein increases autophagy and reduces inflammation and neurotoxic proteins. Significant changes of cerebrospinal fluid microRNAs that control inflammation, neuronal injury, autophagy and vesicular transport genes are observed in PD with and without dementia and Lewy body dementia, but these changes are attenuated or reversed after treatment with the DDR1 inhibitor, nilotinib. Collectively, these data demonstrate that DDR1 regulates autophagy and reduces neurotoxic proteins and inflammation and is a therapeutic target in neurodegeneration.
Long-term exposure to moderate fine particulate matter concentrations and cause-specific mortality in an ageing society
Authors: Lim Youn-Hee , Oh Jongmin , Han Changwoo , Bae Hyun-Joo , Kim Soontae , Jang Yoonyoung , Ha Eunhee , Hong Yun-Chul
Published: August 2020

Background

Long-term exposure to particulate matter <2.5 μm in size (PM2.5) is considered a risk factor for premature death. However, only a few studies have been conducted in areas with moderate PM2.5 concentrations. Moreover, an ageing society may be more susceptible to environmental exposure and future burden of mortality due to PM2.5.

Methods

This study estimates hazard ratios (HRs) for all-cause and cause-specific mortality from long-term exposure to moderate PM2.5 concentrations in the elderly populations of seven cities in South Korea. We also projected nationwide elderly mortality caused by long-term exposure to PM2.5, accounting for population ageing until 2045. Mortality in 1 720 230 elderly adults aged ≥65 years in 2008 was monitored across 2009–16 and linked to modelled PM2.5 concentrations.

Results

A total of 421 100 deaths occurred in 2009–16, and the mean of annual PM2.5 concentration ranged between 21.1 and 31.9 μg/m3 in most regions. The overall HR for a 10 μg/m3 increase in a 36-month PM2.5 moving average was 1.024 (95% confidence intervals: 1.009, 1.039). We estimated that 11 833 all-cause nationwide elderly deaths were attributable to PM2.5 exposure. Annual death tolls may increase to 17 948 by 2045. However, if PM2.5 is reduced to 5 μg/m3 by 2045, the tolls may show a lower increase to 3646.

Conclusions

Long-term exposure to moderately high levels of PM2.5 was associated with increased mortality risk among the elderly. Thus, PM2.5 reduction in response to the projected ageing-associated mortality in South Korea is critical.
Use of linked administrative and laboratory data to confirm that serum 25(OH)D levels in pregnant women can be predicted from satellite estimates of ultraviolet radiation
Authors: Miller Kate M , Lucas Robyn M , Davis Elizabeth A , Hart Prue H , de Klerk Nicholas H
Published: August 2020

Background

Serum 25 hydroxyvitamin D [25(OH)D] levels of pregnant women have been linked to various health outcomes in their offspring. Satellite-derived ultraviolet radiation (UVR) data have been used as a proxy for 25(OH)D levels, as individual-level cohort studies are time-consuming, costly and only feasible for common outcomes.

Methods

Data on 25(OH)D levels from a public laboratory database were linked to data from the Western Australian Midwives’ Notification System and daily erythemal UVR dose from NASA satellites. Regression analysis was used to identify the time period prior to venesection where daily UVR dose best predicted 25(OH)D levels. A predictive model was used to validate the use of daily UVR dose as a proxy for personal sun exposure during pregnancy.

Results

Data from 19 173 pregnancies in women aged 18–43 years in Western Australia were included. The daily UVR dose averaged over the 90 days before venesection was the strongest UVR predictor of 25(OH)D level (a 5% increase per 1000 J m–2; equal to 3.3 nmol L–1 at the median of 66 nmol L–1). Ethnicity was the strongest predictor of 25(OH)D levels (21% lower in non-Caucasian vs Caucasian: equal to 7.2 nmol L–1 difference). Other significant predictors were gestation, age, year, parity, socio-economic status, remoteness, medical conditions and season.

Conclusion

NASA-derived erythemal UVR dose in the 90 days prior to venesection is a significant predictor of 25(OH)D levels in pregnant women. Linked administrative data can be used to investigate associations between UVR during pregnancy and health outcomes in offspring.
Phase retrieval of low-rank matrices by anchored regression
Authors: Lee Kiryung , Bahmani Sohail , Eldar Yonina C , Romberg Justin
Published: August 2020

We study the low-rank phase retrieval problem, where our goal is to recover a $d_1\times d_2$ low-rank matrix from a series of phaseless linear measurements. This is a fourth-order inverse problem, as we are trying to recover factors of a matrix that have been observed, indirectly, through some quadratic measurements. We propose a solution to this problem using the recently introduced technique of anchored regression. This approach uses two different types of convex relaxations: we replace the quadratic equality constraints for the phaseless measurements by a search over a polytope and enforce the rank constraint through nuclear norm regularization. The result is a convex program in the space of $d_1 \times d_2$ matrices. We analyze two specific scenarios. In the first, the target matrix is rank-$1$, and the observations are structured to correspond to a phaseless blind deconvolution. In the second, the target matrix has general rank, and we observe the magnitudes of the inner products against a series of independent Gaussian random matrices. In each of these problems, we show that anchored regression returns an accurate estimate from a near-optimal number of measurements given that we have access to an anchor matrix of sufficient quality. We also show how to create such an anchor in the phaseless blind deconvolution problem from an optimal number of measurements and present a partial result in this direction for the general rank problem.
Supply chain risk management modelling: A systematic literature network analysis review
Authors: Fagundes Marcus Vinicius Carvalho , Teles Eduardo Oliveira , Vieira de Melo Silvio A B , Freires Francisco Gaudêncio Mendonça
Published: August 2020

The modelling of supply chain risk management (SCRM) has attracted increasing attention from researchers and professionals. However, a systematic network analysis of the literature to understand the development of research over time is lacking. Therefore, this study reviews SCRM modelling and its evolution as a scientific field. We collected 566 papers published in the Scopus database and shortlisted 120 for review. We have analysed the field's performance, mapped the most influential studies, as well as the generative and evolutionary research areas, and derived future research directions. Using bibliometric methods and tools for citation network analysis to understand the field's dynamic development, we find that five generative research areas provide the fundamental knowledge for four evolutionary research areas. The interpretation of gaps and trends in these areas provides an SCRM modelling timeline with 14 future research directions, which should consider adopting a holistic SCRM approach and developing prescriptive and normative risk models. The holistic approach enables more research on key factors—like process integration, design, information risk, visibility and risk coordination—that directly impact industry, decision-makers and sustainability needs. Risk models with evolved prescriptive and normative typology should respect both business model strategies and actual supply chain performance.
Error analysis and uncertainty quantification for the heterogeneous transport equation in slab geometry
Authors: Graham Ivan G , Parkinson Matthew J , Scheichl Robert
Published: August 2020

We present an analysis of multilevel Monte Carlo (MLMC) techniques for the forward problem of uncertainty quantification for the radiative transport equation, when the coefficients (cross-sections) are heterogenous random fields. To do this we first give a new error analysis for the combined spatial and angular discretisation in the deterministic case, with error estimates that are explicit in the coefficients (and allow for very low regularity and jumps). This detailed error analysis is done for the one-dimensional space–one-dimensional angle slab-geometry case with classical diamond differencing. Under reasonable assumptions on the statistics of the coefficients, we then prove an error estimate for the random problem in a suitable Bochner space. Because the problem is not self-adjoint, stability can only be proved under a path-dependent mesh resolution condition. This means that, while the Bochner space error estimate is of order $\mathcal{O}(h^{\eta })$ for some $\eta $ where $h$ is a (deterministically chosen) mesh diameter, smaller mesh sizes might be needed for some realisations. We also show that the expected cost for computing a typical quantity of interest remains of the same order as for a single sample. This leads to rigorous complexity estimates for Monte Carlo (MC) and MLMC: for particular linear solvers, the multilevel version gives up to two orders of magnitude improvement over MC. We provide numerical results supporting the theory.
One-Year Decline of Poliovirus Antibodies Following Fractional-Dose Inactivated Poliovirus Vaccine
Authors: Saleem Ali Faisal , Mach Ondrej , Yousafzai Mohammad Tahir , Kazi Zaubina , Baig Attaullah , Sajid Muhammad , Jeyaseelan Vishali , Sutter Roland W , Zaidi Anita K M
Published: August 2020

Background

Fractional dose (one-fifth of full intramuscular dose) of inactivated poliovirus vaccine (fIPV) administered intradermally is used as IPV dose-sparing strategy. We compared the rate of decline of poliovirus antibodies (PVA) in recipients of 2 doses of fIPV or IPV.

Methods

A community-based randomized controlled trial was conducted in Karachi, Pakistan. Children aged 14 weeks were randomized into fIPV or full IPV (study arms A, B) and received 1 vaccine dose at age 14 weeks and 1 at age 9 months. PVAs were measured at age 14, 18 weeks and 10, 21 months.

Results

Seroprevalence of poliovirus type 2 antibodies in 170/250 (68%) children after 2 IPV or fIPV doses at age 10 months in A and B reached 100% vs 99% (P = .339), and at 21 months, 86% vs 67% (P = .004). Between age 10 and 21 months antibody log2 titers dropped from ≥ 10.5 to 6.8 in A and from 9.2 to 3.7 in B.

Conclusions

There was a significant decline in antibody titers 12 months following the second IPV dose. The slope of decline was similar for full IPV and fIPV recipients. The results provide further evidence that fIPV is a viable option for IPV dose-sparing.

Clinical Trials Registration

NCT03286803.
Hospital accreditation impact on healthcare quality dimensions: a systematic review
Authors: Araujo Claudia A S , Siqueira Marina Martins , Malik Ana Maria
Published: August 2020

Purpose

To systematically review the impact of hospital accreditation on healthcare quality indicators, as classified into seven healthcare quality dimensions.

Data source

We searched eight databases in June 2020: EBSCO, PubMed, Web of Science, Emerald, ProQuest, Science Direct, Scopus and Virtual Health Library. Search terms were conceptualized into three groups: hospitals, accreditation and terms relating to healthcare quality. The eligibility criteria included academic articles that applied quantitative methods to examine the impact of hospital accreditation on healthcare quality indicators.

Study selection

We applied the PICO framework to select the articles according to the following criteria: Population—all types of hospitals; Intervention—hospital accreditation; Comparison—quantitative method applied to compare accredited vs. nonaccredited hospitals, or hospitals before vs. after accreditation; Outcomes—regarding the seven healthcare quality dimensions. After a critical appraisal of the 943 citations initially retrieved, 36 studies were included in this review.

Results of data synthesis

Overall results suggest that accreditation may have a positive impact on efficiency, safety, effectiveness, timeliness and patient-centeredness. In turn, only one study analyzes the impact on access, and no study has investigated the impact on equity dimension yet.

Conclusion

Mainly due to the methodological shortcomings, the positive impact of accreditation on healthcare dimensions should be interpreted with caution. This study provides an up-to-date overview of the main themes examined in the literature, highlighting critical knowledge-gaps and methodological flaws. The findings may provide value to healthcare stakeholders in terms of improving their ability to assess the relevance of accreditation processes.
Clinical impact of a Clostridioides (Clostridium) difficile bedside infectious disease stewardship intervention
Authors: Olmedo María , Valerio Maricela , Reigadas Elena , Marín Mercedes , Alcalá Luis , Muñoz Patricia , Bouza Emilio
Published: August 2020

Objectives

To evaluate the clinical impact of a bedside visit to patients with a positive Clostridioides difficile test on the antimicrobial stewardship of C. difficile infection (CDI) and non-C. difficile infections.

Methods

All patients ≥18 years old with positive CDI laboratory tests hospitalized between January 2017 and August 2017 received an immediate bedside intervention that consisted mainly of checking protective measures and providing recommendations on infection control and the management of CDI and other infections.

Results

A total of 214 patients were evaluated. The infectious disease (ID) physician was the first to establish protective measures in 25.2% of the cases. In 22/29 (75.9%) cases, physicians in charge accepted ID consultant recommendations to stop CDI treatment in asymptomatic patients. Unnecessary non-CDI antibiotics were discontinued in 19.1% of the cases. ID recommendations were not accepted by physicians in charge in only 12.6% of the cases.

Conclusions

A bedside rapid intervention for patients with a CDI-positive faecal sample was effective in avoiding overdiagnosis and unnecessary antibiotic treatment, optimizing anti-CDI drugs, increasing compliance with infection control measures and providing educational advice.
On the Basis of Race: The Utility of a Race Factor in Estimating Glomerular Filtration
Authors: Franks Caroline E , Scott Mitchell G
Published: August 2020

Background

Glomerular filtration rate (GFR) is a measure of the combined rate of filtration of all functional nephrons in the kidney. Measurement of GFR is used in the clinic to detect, stratify, and monitor progression of kidney dysfunction, and also serves as a prognostic tool for staging chronic kidney disease (CKD). The gold standard method for measuring GFR is by plasma or urine clearance of exogenous filtration markers, but this is not feasible in routine clinical practice. The most commonly used method to assess GFR is using equations for estimated GFR (eGFR).

Content

Addition of a race factor to eGFR equations has been recommended to optimize performance for Black individuals. Here, we review the basis of the race-based equation and assess its utility and widespread applicability.

Although evidence supporting the performance of a race factor exists in the unique populations in which these estimation equations were derived, more studies are needed to assess the need, or lack thereof, for race factors for all ethnicities. Furthermore, ethnicity is complex and likely cannot be qualified with a 2-level descriptor.
Endogenous GHB in Segmented Hair Part II: Intra-individual Variation for Exogenous Discrimination
Authors: Strickland Erin C , Thomas Jennifer L , Lloyd Erin W , Smith Michael A , LeBeau Marc A , Montgomery Madeline A , Karas Roman P , Peters Eugene M , Miller Mark L
Published: August 2020

The endogenous presence of gamma-hydroxybutyric acid (GHB) complicates the interpretation of results in cases where an exogenous dosing is suspected. Due to GHB’s rapid metabolism and clearance following exogenous doses, hair has become a preferential matrix for confirmation of GHB exposure in drug-facilitated crimes. However, unlike blood and urine where an agreed-upon cut-off concentration for differentiation between endogenous and exogenous GHB has been made, there has been no consensus on a cut-off concentration for hair. This is due in part to the wide inter- and intra-individual variation that has been observed in endogenous GHB hair studies. A large (>50) population study of 214 donors was conducted to better understand these variations and to evaluate whether a cut-off concentration could be established for endogenous GHB in human hair. As seen in our previous study, the inter-individual variation was large, with concentrations ranging from <0.40 to 5.47 ng/mg. This range made an absolute cut-off concentration recommendation inappropriate, so an alternative approach for GHB discrimination was investigated utilizing the intra-individual variation. Male donors appeared to have greater intra-individual variation than female donors, yet it was noted that segment-to-segment variation along the length of hair had minimal change between individual donor’s adjacent segments. Overall, 97.1% of the adjacent segment differences were within ±0.5 ng/mg. Therefore, instead of a recommended cut-off concentration, it appears that using adjacent segment concentration differences could be a strategy to assist in differentiating endogenous from single exogenous GHB exposure. In the absence of controlled dosing data, previously published segmented results from controlled and suspected dosing donors are examined using the adjacent segmental difference approach and the results compared to currently used ratio-based calculations.
Challenging the Hegemony of the Symptom: Reclaiming Context in PTSD and Moral Injury
Authors: Kinghorn Warren
Published: August 2020

Although post-traumatic stress disorder (PTSD) is now constituted by a set of characteristic symptoms, its roots lie in Post-Vietnam Syndrome, a label generated by a Vietnam-era advocacy movement that focused not on symptoms but on war’s traumatic context. When Post-Vietnam Syndrome was subsumed into the abstract, individualistic, symptom-centered language of DSM-III and rendered as PTSD, it not only lost this focus on context but also neglected the experiences of veterans who suffer from things done or witnessed, not primarily from what was done to them, in war. This agent-related trauma has been rediscovered in contemporary work on moral injury, but moral injury too is increasingly subjected to the hegemony of the symptom. Focusing on symptoms, however, unhelpfully pathologizes and individualizes trauma, neglects traumatic context, and legitimates problematic therapeutic approaches. Trauma researchers and clinicians should decenter the language of symptoms and focus instead on context and on alternative accounts of trauma.
Ectopic maxillary tooth as a cause of recurrent maxillary sinusitis: a case report and review of the literature
Authors: Almomen Ali , Alkhudair B , Alkhatib A , Alazzah G , Ali Zainab , Al Yaeesh Ibrahim , AlOmairin Ahmed , Alshuaibi Abdullah , AlBahr Abdulelah
Published: August 2020

This article presents a rare case report of an ectopic third molar tooth located in the medial wall of maxillary sinus in a young male manifesting as recurrent sinusitis along with upper jaw pain and postnasal discharge diagnosed with an ectopic tooth and bilateral dentigerous cysts. This article aims to discuss this rare presentation of an ectopic tooth as a cause of recurrent maxillary sinusitis and the endonasal endoscopic management of the case.
The basic helix-loop-helix transcription factor bHLH95 affects fruit ripening and multiple metabolisms in tomato
Authors: Zhang Lincheng , Kang Jing , Xie Qiaoli , Gong Jun , Shen Hui , Chen Yanan , Chen Guoping , Hu Zongli
Published: August 2020

Ethylene signaling pathways regulate several physiological alterations that occur during tomato fruit ripening, such as changes in colour and flavour. The mechanisms underlying the transcriptional regulation of genes in these pathways remain unclear, although the role of the MADS-box transcription factor RIN has been widely reported. Here, we describe a bHLH transcription factor, SlbHLH95, whose transcripts accumulated abundantly in breaker+4 and breaker+7 fruits compared with rin (ripening inhibitor) and Nr (never ripe) mutants. Moreover, the promoter activity of SlbHLH95 was regulated by RIN in vivo. Suppression of SlbHLH95 resulted in reduced sensitivity to ethylene, decreased accumulation of total carotenoids, and lowered glutathione content, and inhibited the expression of fruit ripening- and glutathione metabolism-related genes. Conversely, up-regulation of SlbHLH95 in wild-type tomato resulted in higher sensitivity to ethylene, increased accumulation of total carotenoids, slightly premature ripening, and elevated accumulation of glutathione, soluble sugar, and starch. Notably, overexpression of SlbHLH95 in rin led to the up-regulated expression of fruit ripening-related genes (FUL1, FUL2, SAUR69, ERF4, and CNR) and multiple glutathione metabolism-related genes (GSH1, GSH2, GSTF1, and GSTF5). These results clarified that SlbHLH95 participates in the regulation of fruit ripening and affects ethylene sensitivity and multiple metabolisms targeted by RIN in tomato.
An analysis of radial pulse strength to recorded blood pressure in the Department of Defense Trauma Registry
Authors: Naylor Jason F , Fisher Andrew D , April Michael D , Schauer Steven G
Published: August 2020

Introduction

Hemorrhage is the leading cause of potentially preventable death on the battlefield. The tactical combat casualty care guidelines recommend the use of the radial pulse strength to guide the administration of blood products or intravenous fluids when equipment for blood pressure monitoring is not available. Data supporting this measurement tool are limited. We sought to validate this method in a deployed trauma population.

Materials and Methods

This is a secondary analysis of a previously published dataset from the Department of Defense Trauma Registry. In this subanalysis, we focused on emergency department radial pulse strength documented in conjunction with systolic blood pressure readings.

Results

Our predefined search codes captured 28,222 Department of Defense Trauma Registry casualties. Of those, 22,192 casualties had at least 1 radial pulse strength documented, with a total of 27,366 documented measurements total among the 22,192. The median age of casualties was 25 years, most were male (96.8%), U.S. military made up the largest proportion (44.2%), most were injured by explosive (55.8%), and most were in Afghanistan (67.0%) with a median injury severity score of 9. Mean systolic blood pressures were significantly different based on radial pulse strength: strong (129.6), weak (107.5), and absent (85.1). However, when using a binary threshold of 80 mmHg, there were 615 documented instances of hypotension. Within that 615, 55.6% had a strong radial pulse, 29.3% had a weak radial pulse, and 15.1% had an absent radial pulse (P < .001).

Conclusions

Although mean systolic blood pressure was associated with radial pulse quality, when using a binary measurement of hypotension (systolic < 80 mmHg) characterization of the radial pulse was not a reliable indicator of hypotension. Better methods for casualty monitoring must be employed to avoid missing opportunities for intervention.