bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of polymorphisms in SLC gene family with risk of leprosy and malformation in Chinese familial and sporadic patients
Authors: Xiaohua Wang , Mei Junpu , Que Shouhong , Li Ming , wu Xueli , Huang Junxin , Zheng Daocheng , Yang Bin
Published: June 2019

Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae, and usually affects the skin surface and peripheral nerves, and may lead to deformities if not be healed. Genes in solute carrier (SLC) super-family encode a series of the largest transport-proteins, and are reported to be associated with several connective tissue diseases. Methods: Here we performed a multiple-stage study to investigate the polymorphisms of SLC gene family in familial leprosy patients using whole exome sequencing data and sporadic leprosy patients using TaqMan custom genotyping assays, in China. Results: We found that, rs202071873 in SLC35E1 is associated with leprosy, rs3731865 in SLC11A1 and rs117820608 in SLC35E2B are associated with the degree of malformation in leprosy. Conclusions: This report of the polymorphisms in SLC gene family supports the view of a important role of human genetics in the natural development of the disease.
Key word：Leprosy；solute carrier (SLC) super-family；Genes
Differences and diversity of autoimmune-mediated encephalitis in 77 cases from a single tertiary care center
Authors: Saraya Abhinbhen Wasontiwong , Worachotsueptrakun Kanthita , Vutipongsatorn Kritchai , Sonpee Chanikarn , Hemachudha Thiravat
Published: June 2019

Background
Since the discovery of N-methyl-D-aspartate receptor (NMDAr) antibody in 2007, the incidence of autoantibody-mediated encephalitis has risen globally. Here we analyzed and compared groups of autoantibody-associated encephalitis patients based on clinical findings and laboratory results in order to find differences between two major groups of autoantibody-mediated encephalitis: intracellular and neuronal surface antibodies.
Methods
77 records of autoimmune encephalitis/encephalomyelitis patients admitted to King Chulalongkorn Memorial Hospital (KCMH) between October 2010 and February 2017 were reviewed. Patients with infections or those with classic central nervous system demyelinating features were excluded. Categorical data was analyzed using chi-square and Fisher’s exact test. Unpaired, two-tailed t-test was performed to analyze numerical data.
Results
Of 77 patients, 40% presented with neuronal surface antibodies and 33% had intracellular antibodies. The most common autoantibody detected in each group was anti-NMDA receptor antibody (25/31, 81%) and anti-Ri antibody (7/25, 28%) respectively. In the neuronal surface antibody group, behavioral change was the most common complaint (45%), followed by seizures (39%), abnormal movements (29%) and psychosis/mood disorder (23%). In the latter group, seizure was the most common presenting symptom (32%), followed by motor weakness (20%), behavioral change (16%) and abnormal movements (16%). Patients with neuronal surface antibodies were significantly younger (35 vs 48 years old, p=0.04) and were more likely to present with behavioral change (45% vs 16%, p=0.02). Mortality rate was higher in the intracellular group although this was statistically insignificant (16% vs 3.2%, p=0.09). No significant differences were detected in magnetic resonance imaging and cerebrospinal fluid (CSF) profile.
Conclusions
The prevalence of neuronal surface antibody group was much higher than the intracellular group. In the earlier stages of the disease, both groups have comparable clinical outcomes. Furthermore, it is difficult to distinguish autoantibody-associated encephalitis patients based on clinical data, neuroimaging and CSF profile. Therefore, we recommend that patients with features of autoimmune encephalitis should be screened for both the neuronal surface and intracellular antibodies regardless of clinical presentation.
A prospective randomized double-blind trial of the efficacy of a bilateral lumbar erector spinae block on the 24h morphine consumption after posterior lumbar interbody fusion surgery
Authors: breebaart margaretha , Aken David Van , De Fré Olivier , Sermeus Luc , Kamerling Niels , Michielsen Jozef , De Jong Lars , Roelant Ella , Saldien Vera , Versyck Barbara
Published: June 2019

Abstract
Background: Spine surgery is associated with considerable postoperative pain and can be challenging to treat. A loco-regional technique suitable for spine surgery should cover the dorsal root of the spinal nerves at the levels where surgery is performed. The erector spinae block is a loco-regional technique with promising results that was recently described at the thoracic level. There are no randomized trials of this technique on a lumbar level. This study tests the hypothesis that the 24hour postoperative morphine consumption is significantly lower in patients undergoing posterior lumbar inter-body fusion surgery with a lumbar erector spinae (LUMBES) block when compared to a sham block.

Methods:
This prospective randomized double-blind multicentre study will randomly allocate 80 adult patients undergoing elective posterior lumbar inter-body fusion surgery during general anaesthesia to one of two groups as follows: 1. bilateral erector spinae block (20 mL 0,25% levobupivacaine) or 2. bilateral sham block (20 ml NaCl 0,9%). Our primary endpoint is the 24-hour postoperative morphine consumption. Secondary endpoints include: 72-hour morphine consumption, intraoperative sufentanil dosage, postoperative pain scores at regular time intervals both at rest and during movement, time to first post-operative mobilization and the Quality of Recovery 40 score.

Discussion: The LUMBES trial is a pragmatic clinical study that will provide evidence of whether a bilateral lumbar erector spinae block is effective in reducing 24-hour postoperative morphine consumption in patients undergoing lumbar inter-body fusion surgery. If this hypothesis is confirmed, this finding could contribute to more widespread implementation of this technique.
OCT Angiography of Persistent Hyaloid Artery: A case report
Authors: Jeon Hansol , Kim Jinsoo , Kwon Soonil
Published: June 2019

Background

A persistent hyaloid artery is a rare fetal remnant. Several complications such as amblyopia, vitreous hemorrhage, and retinal detachment have been reported. Here, we present a case of vitreous hemorrhage with a persistent hyaloid artery.

Case presentation

A healthy 16-year-old male presented with blurred vision in his left eye. Vitreous hemorrhage occurred and absorbed spontaneously. Slit-lamp examination demonstrated a Mittendorf’s dot and fundus examination revealed a persistent hyaloid artery. Optical coherence tomography showed a Bergmeister’s papilla. The blood flow of the persistent hyaloid artery via the Bergmeister’s papilla was found by OCT angiography.

Conclusion

The persistent hyaloid artery should be considered as a cause of spontaneous vitreous hemorrhage of young healthy patient. The OCT angiography will be a useful noninvasive approach to confirm the patency of the persistent hyaloid artery.
Small, but surprisingly repetitive genomes: Transposon expansion and not polyploidy has driven a doubling in genome size in a metazoan species complex
Authors: Blommaert Julie , Riss Simone , Hecox-Lea Bette , Mark-Welch David B. , Stelzer Claus-Peter
Published: June 2019

Background: The causes and consequences of genome size variation across Eukaryotes, which spans five orders of magnitude, have been hotly debated since before the advent of genome sequencing. Previous studies have mostly examined variation among larger taxonomic units (e.g., orders, or genera), while comparisons among closely related species are rare. Rotifers of the Brachionus plicatilis species complex exhibit a seven-fold variation in genome size and thus represent a unique opportunity to study such changes on a relatively short evolutionary timescale. Here, we sequenced and analysed the genomes of four species of this complex with nuclear DNA contents spanning 110- 422 Mbp. To establish the likely mechanisms of genome size change, we analysed both sequencing read libraries and assemblies for signatures of polyploidy and repetitive element content. We also compared these genomes to that of B. calyciflorus, the closest relative with a sequenced genome (293 Mbp nuclear DNA content).
Results summary: Despite the very large differences in genome size, we saw no evidence of ploidy level changes across the B. plicatilis complex. However, repetitive element content explained a large portion of genome size variation (at least 54%). The species with the largest genome, B. asplanchnoidis, has a strikingly high 44% repetitive element content, while the smaller B. plicatilis genomes contain between 14% and 25% repetitive elements. According to our analyses, the B. calyciflorus genome contains 39% repetitive elements, which is substantially higher than previously reported (21%), and suggests that high repetitive element load could be widespread in monogonont rotifers.
Conclusions: Even though the genome sizes of these species are at the low end of the Metazoan spectrum, their genomes contain substantial amounts of repetitive elements. Polyploidy does not appear to play a role in genome size variations in these species, and these variations can be mostly explained by changes in repetitive element content. This contradicts the naïve expectation that small genomes are streamlined, or less complex, and that large variations in nuclear DNA content between closely related species are due to polyploidy.
Comparison of the effect of three different protein content enteral diets on serum levels of proteins, nitrogen balance and energy expenditure in critically ill infants: study protocol for a randomized controlled trial
Authors: Montes Reyes Fernández , Villaescusa Javier Urbano , Álvarez Ángel Carrillo , Allende Ana Vivanco , García María José Solana , Galán Corsino Rey , Cid Jesús López-Herce
Published: June 2019

Background

Nutritional support is essential in the care of critically ill children, since malnutrition in this population is associated to increased morbidity and mortality. Injury in patients admitted to pediatric intensive care units (PICU) results in a catabolic state, with augmented protein breakdown, leading to a negative protein balance. Current recommendations about protein prescription in PICU are fundamentally based on expert opinions, with a minimum threshold of 1.5 g/kg/day of protein, although protein needs could be higher in certain subgroups of patients. The main objective of the present study is to examine if the administration of a protein-enriched infant formula increases the serum levels of total proteins, albumin, prealbumin, transferrin, retinol, and improves nitrogen balance; and to analyze the effect of the high-protein diet on energy expenditure. A secondary objective is to register possible secondary effects of the protein-enriched diet.

Methods

a multicenter prospective randomized controlled trial (RCT) will be performed in three hospitals. Patients meeting inclusion criteria will be randomly allocated to one of three enteral feeding formula with different protein content. Blood and urine test, nitrogen balance assessment and energy expenditure testing by indirect calorimetry will be performed at the beginning of nutrition regimen and at 24 hours, 72 hours and 5-7 days after initiation. The sample size for this trial is estimated as 90 participants, with approximately 30 participants in each group. The data analysis will be by intention to treat.

Discussion

this RCT will provide new data about the amount of protein needed to improve levels of serum protein and nitrogen balance, surrogate of protein balance, in critically ill infants receiving enteral nutrition.
“Due to the side effects she has when using the method it will be difficult for nurses to convince her to continue with that method. That’s why I said she will leave with another method.”: Family planning providers and contraceptive users in Rwanda do not consider discontinuation an option
Authors: Schwandt Hilary M. , Boulware Angel , Corey Julia , Herrera Ana , Hudler Ethan , Imbabazi Claudette , King Ilia , Linus Jessica , Manzi Innocent , Merritt Maddie , Mezier Lyn , Miller Abigail , Morris Haley , Musemakweli Dieudonne , Musekura Uwase , Mutuyimana Divine , Ntakarutimana Chimene , Patel Nirali , Scanteianu Adriana , Shemeza Biganette-Evidente , Stapleton Madi , Sterling-Donaldson Gi'anna , Umutoni Chantal , Uwera Lyse , Zeiler Madeleine , Feinberg Seth
Published: June 2019

Background

Contraceptive discontinuation is a common event. Family planning programs often focus more on recruitment of new users as opposed to maintaining use among current users. A focus on sustaining users is imperative for long-term family planning program success.

Methods

This qualitative study in Rwanda in 2018 included eight focus group discussions with family planning providers and 32 in-depth interviews with contraceptive users. The data were collected in the two districts with the highest and lowest rates of contraceptive use, Musanze and Nyamasheke, respectively. The aim of this study is to better understand contraceptive use dynamics in Rwanda.

Results

Family planning providers and current users in Rwanda do not consider method discontinuation an option. Providers give support and medicine for side effects for continuers and counseling for those opting to switch. Current users are willing to try many methods until they find the right one for them – and once they find the right method, they plan to, or use the method, for long durations.

Conclusions

The Rwandan family planning program is primed to meet the needs of users in their sustained use of contraceptives through empathetic and responsive counseling. Concurrently, family planning users are determined to use family planning to meet their desired family size goals. The matching goals of both providers and clients indicates that contraceptive use will likely continue to increase in the future in Rwanda; however, due to long periods of pregnancy prevention desired – increased use of long acting methods should be encouraged.
The Gauge-Higgs legacy of the LHC run II
Authors: Biekoetter Anke , Corbett Tyler , Plehn Tilman
Published: June 2019

We present a global analysis of the Higgs and electroweak sector
based on LHC Run II and electroweak precision observables. We show which
measurements provide the leading constraints on Higgs-related operators,
and how the achieved LHC precision makes it necessary to combine rate
measurements with electroweak precision observables. The SFitter
framework allows us to include kinematic distributions beyond
pre-defined ATLAS and CMS observables, independently study correlations,
and avoid Gaussian assumptions for theory uncertainties. These Run II
results are a step towards a precision physics program at the LHC,
interpreted in terms of effective operators.
Life cycle analysis of raw milk production in Tunisia
Authors: Ghazouani Amira , Mhamdi Naceur , Znaidi Ibrahim-El-Akram , Darej Cyrine , Guoiaa Norchene , Hasnaoui Maroua , Bouraoui Rachid , Mhamdi Hajer
Published: June 2019

Life Cycle Assessment (LCA) is a tool to calculate greenhouse gas (GHG) emissions of dairy production. A survey was conducted in 20 dairy farms at the governorate of Sousse. The present study aimed to evaluate environmental impact of milk production at the farm regarding GHG emission and energy consumption. In the 20 dairy farms total GHG emissions resulted in a mean of 0.63 +/- 0.2 kg CH4/kg ECM and forage can contribute with a means 0.35 Le kg CO2eq/DM. The main reductions in GHG emissions per kg of FPCM started from 2,347 kg per cow per year and then the reduction slowed down to stabilize at around 6,127 kg FPCM per cow per year.
¿Teoría crítica o inmunización del sistema? Acerca de la dicotomía habermasiana entre sistema y mundo de la vida.
Authors: García-Granero Marina , Ortega Esquembre César
Published: June 2019

El artículo presenta las fuentes y la definición de los conceptos sistema y mundo de la vida, poniendo de relieve cómo la colonización del mundo de la vida por parte del sistema aparece como un proceso patológico, frente al cual cabe mantener un posicionamiento crítico. Ante el aumento de la complejidad sistémica, es necesario asegurar la reproducción simbólica del mundo de la vida a través de la acción comunicativa. Compartiendo con Habermas el sentido de sus problematizaciones, presentamos sin embargo diversas objeciones a la oposición dicotómica de ambas esferas, en la medida en que ésta confiere a los sistemas económico y administrativo un estatuto ontológico que acaba blindándolos ante toda posible crítica.
Kunst in de openbare ruimte van een nieuwe stadswijk
Authors: Gorter Dirk
Published: June 2019

In het Structuurplan Amsterdam uit 1990, werd de Middelveldsche Akerpolder aangewezen als een omvangrijke woningbouwlokatie, om ook hier te kunnen voldoen aan de grote woningbehoefte. Bij de inrichting en de bouw van de Aker is een aantal beeldend kunstenaars betrokken.
GENOTYPE AND ABO BLOOD GROUP ASSOCIATION WITH PREVALENCE OF MALARIA AMONG PATIENTS IN UNIVERSITY OF NIGERIA MEDICAL CENTER: A CROSS-SECTIONAL EVALUATION
Authors: Isah Abdulmuminu , Anosike Chibueze , Ogbodo Chukwuma Stephen , Emeka Charles Obinna , Nworu Chukwuemeka Sylvester
Published: June 2019

Objective: The aim of this study was to evaluate the prevalence of malaria and its relationship with the ABO blood group and genotype at the University of Nigeria Medical Centre.

Methods: The study had a prospective cross-sectional design in which malaria status and blood groups and genotype were determined. All collected data were analysed using Statistical product and services Solution (V.21). Frequencies and percentages were used to describe the data while Chi-square and Pearson correlation were used to determine associations between malaria prevalence and patients’ demographic and clinical characteristics. Statistical significance was considered for p<0.05.

Results: Three hundred and twenty-three (323) patients were tested for malaria, 245(75.9%) of whom tested positive. The prevalence was highest for patient’s aged 19-25 y (28.5%). The difference was statistically significant for age: χ2 (5) = 33.60, p = 0.0005. There were more blood group O (57.6%) among the patients, while AA genotype was the majority (72.4%). Those with blood group O had the highest prevalence of malaria (33.7%) and it was statistically significant (χ2 (3) = 72.10, p = 0.0005)). Correlation showed that the association between blood group and malaria prevalence was moderate (R = 0.457). The AA genotype had more incidence of malaria (54.5%), but the difference was not statistically significant.

Conclusion: The prevalence of malaria was high among the patients surveyed. Its association with the patients’ ABO blood group was established to be statistically significant, with blood group O having the highest incidence. Although AA genotype was observed to have the highest cases of malaria, the relationship was found not to be significant.
DESIGN, SYNTHESIS, MOLECULAR DOCKING, ADMET STUDIES AND BIOLOGICAL EVALUATION OF PYRAZOLINE INCORPORATED 1, 2, 3-TRIAZOLE BENZENE SULPHONAMIDES
Authors: SILIVERI SRAVANTHI , BASHABOINA NAGARAJU , VAMARAJU HARINADHA BABU , Raj Shiva
Published: June 2019

Objective: The main objective of this work was to design, synthesize and evaluate the novel pyrazoline incorporated 1,2,3-triazole benzene sulphonamides for cytotoxic and anti-gout activities also to perform Insilco molecular docking studies.

Methods: Designed compounds were synthesized by condensation of different substituted chalcones (3a-i) with hydrazine hydrate and substituted phenylhydrazines. All the synthesized compounds were characterized on the basis of physical and spectral data. To predict the affinity and activity of the ligand molecule Libdock program was employed to generate different bioactive binding poses of designing molecules at the active site of protein Phosphatidylinositol 3-kinase (PI3Kα). Title compounds were evaluated for cytotoxic activity by using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and anti-gout activity by potassium oxonate induced assay.

Results: All the synthesized compounds showed characteristic peaks in FTIR, 1H, 13C NMR and MASS spectral analysis. In molecular docking studies, compound 3i has shown good binding affinity to the active site of PI3Kα with a docking score of 145.031 and 4 hydrogen bonding interactions with least hepatotoxicity and good bioavailability when compared with that of reference ligand KKR exhibited a Libdock score of 88.35. Remaining compounds also have a good binding affinity with a minimum of 2 bonding interactions and having better absorption, distribution, metabolism, elimination and toxicity (ADMET) profile. The same compound (3i) exhibited the highest cytotoxic activity with an IC50 value of 4.54µg/ml. Compound 4d was evaluated for anti-inflammatory activity and it has significantly ameliorated against potassium oxonate induced gout in mice when compared with that of standard drug allopurinol due to its anti-inflammatory property.

Conclusion: We designed and synthesized a novel series of title compounds in quantitative yields and performed docking studies. New derivatives have a good binding affinity towards PI3Kα enzyme, good bioavailability, least hepatotoxicity and significant cytotoxic activity.
Uso de las tecnologías de la información y la comunicación por universitarios mayas en un contexto de brecha digital en México
Authors: Gómez Navarro Dulce Angélica
Published: June 2019

El objetivo del artículo es analizar la disponibilidad y uso de las tecnologías de la información y la comunicación y las habilidades digitales de estudiantes de la Universidad Intercultural Maya de Quintana Roo. La metodología integró grupos focales, entrevistas a profundidad, observación participante y un cuestionario. Según los resultados, la mayoría de los alumnos usan teléfono celular e internet con propósitos educativos y de ocio; manejan procesadores de datos y herramientas básicas de conectividad. La limitación del estudio es que se basó solo en los resultados del cuestionario. Los hallazgos muestran que los jóvenes usan computadora, internet, teléfono celular y redes sociales para satisfacer necesidades escolares y sociales, en función de sus condiciones económicas e infraestructura disponible. Además, ellos cuentan con habilidades digitales previas, marcadas históricamente por la marginación y el rezago educativo y tecnológico, pero se apropian de las tecnologías para participar en la era digital, cada vez más presente en las comunidades rurales e indígenas de México.
Conflicting interests: Going public in deteriorating market conditions
Authors: Fan Pengda , Wang Lin , Nguyen Thi Phuong Thanh
Published: June 2019

The purpose of this paper is to analyze whether the conflicting interest between issuing firms and CEOs (venture capitalists) affect the going-public decision. Going public in deteriorating market conditions is costly for issuing firms in terms of low offering price and high probability of withdrawal. If agency costs exist, agents pursuing their own interests may bring firms public even in poor market conditions, which has been largely ignored in the previous literature.
To examine our hypotheses, we collect 1246 Japanese firms going public from 2001 to 2016 and conduct logit regressions, propensity score matching (PSM) as well as a probit model with sample selection. Consistent with our conjecture, we find a positive relation between the going-public decision and secondary shares offered by CEOs. Additionally, we also find an inverse U-shaped relationship between CEOs’ retained ownership and the going-public decision, indicating that in addition to liquidity needs, private benefits of control is another potential source of conflicting interests. Furthermore, secondary shares offered by VCs are also positively associated with the going-public decision, suggesting that when VCs attempt to exit as rapidly as possible, they are more likely to bring firms public even in deteriorating markets. These findings suggest that conflicting interests among parties affect the timing and costs of IPOs.
As fontes judiciais como material de pesquisa para a História Social e Política: os processos de acidentes de trabalho no contexto da legislação social
Authors: Mandelli Bruno , Zanelatto João Henrique
Published: June 2019

Este artigo aborda a importância das fontes judiciais para as pesquisas no campo da História social e política, em especial às questões relativas ao mundo do trabalho. Desde as instituições jurídicas e seus modos de funcionamento, passando pela história do cotidiano dos trabalhadores e das suas lutas por direitos, bem como das variadas concepções em torno das leis, dos direitos e da justiça, as fontes jurídicas fornecem um rico material para análise do historiador. Especificamente, o artigo problematiza a questão da pesquisa nos arquivos judiciais, em especial dos processos de acidentes de trabalho, como uma fonte jurídica que possui especificidades que devem ser levadas em consideração pelo pesquisador. Para tanto, aprofunda uma análise da legislação de acidentes de trabalho no Brasil desde a sua instituição, em 1919, até a Reforma da Lei de Acidentes de Trabalho, em 1944, e a sua relação com a instituição da Justiça do Trabalho, outra importante produtora de fontes jurídicas para as pesquisas relacionadas ao mundo do trabalho.
Zacarias de Góes e Vasconcelos e seus discursos no Senado entre 1868 e 1869
Authors: Schmitt da Silva Jaqueline
Published: June 2019

Neste trabalho, pretendemos abordar a crise de 1868 e a atuação de Zacarias de Góes e Vasconcelos através da análise do conteúdo de quatro discursos proferidos no Senado do Império entre 30 de junho de 1868 e 26 de junho de 1869. Tais discursos abordavam as disputas políticas entre os conservadores e a liga progressista, os debates acerca das atribuições do poder moderador, o senado vitalício e sua influência nas decisões, bem como “a causa e o modo” da sua exoneração em julho de 1868 e da queda do gabinete de 3 de agosto. A crise ministerial de 1868 abriu espaço para a exacerbação das críticas à ordem vigente, além de cisão dentro dos partidos Liberal e Conservador e a configuração de novos grupos que reivindicavam espaço para participação na política.
Temperature fields in linear stage of friction stir welding: Effect of different material properties
Authors: Veljic Darko , Rakin Marko , Medjo Bojan , Mrdak Mihailo , Sedmak Aleksandar
Published: June 2019

Friction stir welding is one of the procedures for joining the parts in solid state. Thermo-mechanical simulation of the friction stir welding of high-strength aluminium alloys 2024 T3 and 2024 T351 is considered in this work. Numerical models corresponding to the linear welding stage are developed in Abaqus software package. The material behaviour is modelled by Johnson-Cook law (which relates the yield stress with temperature, strain and strain rate), and the Arbitrary Lagrangian-Eulerian technique is applied. The difference in thermo-mechanical behaviour between the two materials has been analysed and commented. The main quantities which are considered are the temperature in the weld area, plastic strain, as well as the rate of heat generation during the welding process.
Model for the analysis of thermal conductivity of composite material of natural origin
Authors: Milicic Ilija , Folic Radomir , Prokic Aleksandar , Ceh Arpad
Published: June 2019

Thermal properties of the wall structure elements made from gel and straw (?Ethno-eco-passive houses?) have been investigated. The gel was made from a mixture of clay, lime, and water. A 1-D mathematical model based on the continuum mechanics, for predicting the thermal conductivity, is proposed. The results obtained by applying the proposed mathematical model were compared with the measurement data of experimental tests, using the Isomet 2114 instrument. The program envisages the measurement of thermal conductivity of three specimens, 5-year-old, comprising three series within 365 days. In the theoretical analysis, the same parameters of thermal stability were treated as in the experiment. The average value of the material thermal conductivity is 0.0990 W/mK, so it can be concluded that, the composite material intended for the envelope of the proposed constructive system ?Ethno-eco-passive house? is verified as thermally suitable.
A semi-analytical solution of 3-D transient temperature field for a uniform plate subjected to Gaussian-distribution laser heat source
Authors: Wang Xiaogui , Xiao Yili , Gao Ninghua , Liang Lihua , Lu Congda , Jiang Haojie
Published: June 2019

One 3-D transient temperature field model for a thin uniform plate caused by a moving laser heat source is described in present study. The heat source model with a power density in Gaussian-distribution form is considered when a finite-thin uniform plate is heated. By using the separate variable method and the Newton-Cotes method, a semi-analytical solution of 3-D heat conduction equation in the finite field is obtained. Numerical results show that the effect of laser heat source distribution, laser moving speed as well as aspect ratio of the thin uniform plate have great influence on the 3-D distribution of the temperature field.
Development of a national index for the purpose of forest fire risk assessments on the example of southern Serbia
Authors: Ratknic Tatjana , Ratknic Mihailo , Rakonjac Nikola , Zivanovic Ivana , Poduska Zoran
Published: June 2019

The paper presents the results on the study of the possible application of the Canadian Forest Fire Weather Index and the Modified Angstrom Index in forest fire risk assessments. The daily values of these indices for the period 2005-2015 were related to the forest fire database. It was found that there is a relatively weak to moderate correlation between forest fires and the values of the Canadian Forest Fire Weather Index. In order to improve the wildfire risk assessments (including forest fires), the index was modified. The modified index has a significantly greater correlation with the actual events of forest fires and consequently a much wider application in southern Serbia. The modified index can be of great importance in the future concepts of forest fire risk management.
Upper-convected Maxwell fluid analysis over a horizontal wedge using Cattaneo-Christov heat flux model
Authors: Asmadi Muhammad , Kasmani Ruhaila , Siri Zailan , Sivasankaran Sivanandam
Published: June 2019

Boundary-layer flow of upper-convected Maxwell fluid over a wedge with suction and heat generation/absorption is presented in this paper by considering the Cattaneo-Christov heat flux model. The governed equations are transformed into a set of the ODE using similarity transformations. A third-order finite difference method for the ODE is used to find the local similarity solutions of the problems. The effects of the wedge angle parameter, viscoelastic fluid parameter, thermal relaxation time parameter, and heat generation/absorption parameter are presented in this study.
1-OR: Effect of Duodenal-Jejunal Bypass Liner on Cardiovascular Risk in Patients with Type 2 Diabetes and Metabolic Syndrome
Authors: LAUBNER KATHARINA , RÖHLEN NATASCHA , BETTINGER DOMINIK , HILGER HANNA , KÖNIG CAROLIN , KREBS ANDREAS , SEUFERT JOCHEN
Published: June 2019

Introduction: The duodenal-jejunal bypass liner (DJBL) is an antiresorptive endoscopic treatment option for type 2 diabetes (T2DM) and obesity. The effects of DJBL on cardiovascular risk parameters remain elusive.

Methods: We implanted in 71 patients with T2DM and metabolic syndrome a DJBL for 9-12 months. At implantation, 3 months, explantation, 3 and 6 months follow-up, data on blood sugar, body weight, blood pressure and lipid status were collected. Serum samples were analysed for dynamics of cardiovascular biomarkers: high sensitive CRP (HsCRP); lipoprotein-associated phospholipase A2 (Lp-PLA2); Homoarginine; symmetrical dimethylarginin (SDMA), assymetrical dimethylarginine (ADMA), and low densitiy lipoprotein (LDL) subfractions. Overall cardiovascular risk was estimated by Advanced-Risk-Engine at time of implantation, explantation and after 6 months of follow-up.

Results: Implantation of DJBL was accompanied by significant decrease of body weight and improvement of blood sugar. We observed decrements of systolic blood pressure, LDL and triglyceride levels in the course of DJBL implantation (p=1x10-3, p=2x10-3, p=0.01). hsCRP, Lp-PLA2 and small dense lipoprotein fraction LDL-4 showed significant decreases after implantation (hsCRP: V1 vs. V6, p=1x10-3, Lp-PLA2: V1 vs. V5, p<1x10-3, LDL-4: V1 vs. V5, p=0.04). Unexpectedly, decreased homoarginine levels after DJBL-implantation correlated with body weight reduction, possibly reflecting catabolic metabolism. Estimated overall cardiovascular risk by Advanced-Risk-Engine decreased after implantation and remained stable within 6 months of follow-up.

Discussion: Above recent reports of beneficial effects of DJBL on weight loss, glycemic control and lipid parameters in patients with metabolic syndrome, this is the first study that revealed significant impact on serological cardiovascular biomarkers, indicating possible protective effects of DJBL on cardiovascular outcome.

Disclosure

K. Laubner: Research Support; Self; Boehringer Ingelheim International GmbH, GI Dynamics, Inc. Speaker's Bureau; Self; AstraZeneca, Berlin-Chemie AG, Boehringer Ingelheim International GmbH, Merck Sharp & Dohme Corp., Novartis AG. N. Röhlen: None. D. Bettinger: None. H. Hilger: None. C. König: None. A. Krebs: None. J. Seufert: None.

Funding

GI Dynamics
10-LB: Factors Associated with Fear of Hypoglycemia among the T1D Exchange Glu Population
Authors: LIU JINGWEN , MITCHELL BETH , BISPHAM JEOFFREY , FAN LUDI , HUGHES ALLYSON , MCAULIFFE-FOGARTY ALICIA
Published: June 2019

Fear of hypoglycemia (FoH) has been associated with suboptimal diabetes management and health outcomes. The American Diabetes Association recommends further mental health evaluation and treatment if a person with diabetes has a positive screen for FoH. This study investigated factors associated with behavioral and emotional aspects of FoH among adults living with T1D. The study included 494 participants from T1D Exchange Glu (mean [SD] age 43.9 ± 12.2 years, duration of T1D 16.6 ± 16.8 years, self-reported A1c 6.9 ± 0.8%), 63% male, 89% on insulin pump, 25% experienced a severe hypoglycemic event in the last six months. The Hypoglycemia Fear Scale (HFS-II) short form and the Hypoglycemia Attitudes and Behavior Scale (HABS) were used to assess FoH. Multivariable regression analyses showed that higher anxiety, higher depression, and higher diabetes distress were associated with FoH (Table 1). Longer duration of diabetes was associated with lower FoH. Ever experienced severe low blood glucose was associated with higher worry of hypoglycemia but not avoidance behavior. Higher avoidance behavior but not worry/anxiety of hypoglycemia was associated with higher A1c or more diabetes-related comorbidities. These results highlighted the multifaceted nature of FoH and suggest that positive screen for anxiety, depression, or diabetes distress warrants further discussion on FoH between providers and patients with T1D.

Disclosure

J. Liu: None. B. Mitchell: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company. J. Bispham: None. L. Fan: Employee; Self; Lilly Diabetes. Stock/Shareholder; Self; Lilly Diabetes. A. Hughes: None. A. McAuliffe-Fogarty: None.
10-OR: Health-Care Costs and Utilization for Medicaid Patients with Diabetes in Accountable Care Communities (ACC)—A Natural Experiment for Translation in Diabetes (NEXT-D) 2 Study
Authors: MOIN TANNAZ , DURU O. KENRIK , MANGIONE CAROL
Published: June 2019

Background: Diabetes costs account for 20% of all health care spending in the U.S. The Accountable Care Communities (ACC) Program was developed by a large U.S. insurer to provide practices with community data analytics for population management and nurses to support care improvement for Medicaid patients. We examined changes in costs and utilization for Medicaid patients with diabetes in ACC compared to non-ACC practices.

Methods: We used interrupted time series (ITS) analysis of mean costs per person-month between 2009-2015. We used data from patients with diabetes in practices with >1000 Medicaid patients. ACC was implemented in 14 states and comparison non-ACC practices were matched on state to control for state-level variation in Medicaid generosity. Separate ITS models were used for costs, ER visits and hospitalizations adjusted for age, gender, race/ethnicity, seasonality, and state by year fixed effects. Results are presented as differences-in-post-intervention monthly changes-in-expenditures (DID) by Medicaid category (TANF, SSI, Expansion and Duals).

Results: The sample included 899,273 ACC-person months from 54,721 Medicaid patients with diabetes. Over 29 months follow-up, ACC assignment was associated with significant increases in total costs at the time of implementation for all Medicaid patients except for those eligible for both Medicare/Medicaid (Duals); increases in total costs at implementation ranged from $65-143/person-month based on Medicaid category, p<0.05. There were no significant differences in ER use or hospitalizations over time for Medicaid patients with diabetes assigned to ACC practices.

Conclusions: Medicaid patients in ACC practices had increases in costs but not utilization over 2 years follow-up, compared to patients in non-ACC practices. Our findings suggest that this ACC program may not reduce costs of care or utilization for Medicaid patients with diabetes.

Disclosure

T. Moin: None. O. Duru: Advisory Panel; Self; Healthwise. C. Mangione: None.

Funding

Centers for Disease Control and Prevention; National Institutes of Health (U18DP006128)
1026-P: Dipeptidyl Peptidase-4 Inhibitor Treatment and the Risk of Bullous Pemphigoid and Other Skin-Related Adverse Events: A Meta-analysis
Authors: YANG WENJIA , CAI XIAOLING , ZHANG SIMIN , HAN XUEYAO , JI LINONG
Published: June 2019

Background: There were several case reports on the association between dipeptidyl peptidase-4 inhibitors (DPP-4is) and bullous pemphigoid (BP). The aim of this meta-analysis was to evaluate the risk of BP and other skin-related adverse effects (AEs) in patients with type 2 diabetes receiving DPP-4i treatment in randomized controlled trials (RCTs).

Methods: In this meta-analysis, we searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials from inception to November 10, 2018. The study included RCTs assessing the effects of DPP-4is treatment compared with placebo in type 2 diabetic patients with reports of skin-related events. The odds ratio (OR) was calculated by Peto's methods.

Results: 46 randomized placebo-controlled trials with reports of skin-related events were included (n = 59,332) in this meta-analysis. Compared with placebo, the risk of BP significantly increased in DPP-4i treatment (OR = 7.39, 95% CI 2.59-21.07, I2=0%, P = 0.0002) (Figure 1), and the overall risk of skin-related AEs also increased in DPP-4i treatment (OR = 1.31, 95% CI 1.08-1.59, I2=38%, P = 0.006) (Figure 2).

Conclusions: This meta-analysis suggested that DPP-4i treatment was associated with a significant increase in the risks of BP and skin-related AEs.

Disclosure

W. Yang: None. X. Cai: None. S. Zhang: None. X. Han: None. L. Ji: Advisory Panel; Self; AstraZeneca. Consultant; Self; AstraZeneca, Bayer AG, Boehringer Ingelheim International GmbH, Bristol-Myers Squibb Company, Eli Lilly and Company, Merck KGaA, Merck Sharp & Dohme Corp., Novartis AG, Novo Nordisk A/S, Roche Pharma, Sanofi, Takeda Pharmaceutical Company Limited. Research Support; Self; AstraZeneca, Bristol-Myers Squibb Company, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novartis AG, Roche Pharma, Sanofi.
1027-P: A Phase 1, Open-Label, Single-Dose Study to Evaluate Pharmacokinetics of MEDI0382 in Patients with Renal Impairment
Authors: KLEIN GERNOT K. , PETRONE MARCELLA , YANG YE , HOANG THUONG , DICOSTANZA SHEILA , HANSEN LARS , FLOR ARMANDO
Published: June 2019

MEDI0382, an oxyntomodulin-like peptide with targeted GLP-1 and glucagon receptor activity, is in development for T2DM. This open-label, parallel-group study (NCT03235375) evaluated PK of SC MEDI0382 (100 µg; single dose) in subjects (N = 37) grouped by renal function: Group 1, ESRD or severe renal impairment (RI; CrCl < 20 mL/min); Group 2, severe RI (CrCl ≥ 20 mL/min to < 30 mL/min); Group 3, healthy controls (CrCl ≥ 90 mL/min); Group 4a, moderate RI (CrCl ≥ 30 mL/min to < 45 mL/min); and Group 4b, moderate RI (CrCl ≥ 45 mL/min to < 60 mL/min). Coprimary endpoints were geometric mean ratio AUC48h and Cmax of MEDI0382 (Table 1). MEDI0382 had similar PK profiles across all groups (Table 2). This suggests that PK of MEDI0382 is unaffected by renal function, allowing dosing in subjects with RI in future trials.

Disclosure

G.K. Klein: None. M. Petrone: Employee; Self; MedImmune. Y. Yang: Employee; Self; MedImmune. T. Hoang: Employee; Self; MedImmune. S. DiCostanza: Employee; Self; AstraZeneca. L. Hansen: Employee; Self; AstraZeneca, MedImmune. Stock/Shareholder; Self; Bristol-Myers Squibb Company, Novo Nordisk A/S. A. Flor: Employee; Self; AstraZeneca.
1028-P: Is Once-Weekly GLP-1 Receptor Agonist a Reasonable Option for Glucocorticoid-Induced Hyperglycemia? Twelve-Week Efficacy and Safety of Dulaglutide vs. Sitagliptin in Patients with Diabetes on Routine Glucocorticoid Treatment
Authors: YOSHIJI SATOSHI , IWASAKI YORIHIRO , IWASAKI KANAKO , AIZAWA-ABE MEGUMI , HONJO SACHIKO , WADA YOSHIHARU , FUJIKAWA JUN , HAMASAKI AKIHIRO
Published: June 2019

Background: The efficacy and safety of incretin-based therapies for glucocorticoid-induced hyperglycemia, for which insulin is often used, remain to be established in real-world clinical settings. We aimed to study whether a once-weekly GLP-1 receptor agonist improves glycemic control in patients on glucocorticoid therapy compared with a DPP-4 inhibitor.

Methods: We retrospectively compared the 12-week efficacy and safety of dulaglutide versus sitagliptin in patients with diabetes on prednisolone treatment (4-40 mg/day) who visited our hospital from 2015 to 2018.

Results: Among 73 patients who started dulaglutide or sitagliptin for glucocorticoid-induced hyperglycemia while on prednisolone treatment (4-40 mg/day), 40 patients continued dulaglutide or sitagliptin along with prednisolone (4-40 mg/day) for the entire treatment period of 12 weeks (n =16, 24, respectively). The baseline characteristics and change in prednisolone doses from baseline to 1-12 weeks were comparable between the two groups. Dulaglutide significantly reduced the HbA1c and total daily insulin doses per bodyweight from baseline to 12 weeks (-0.78, p = 0.034; -0.29, p = 0.001, respectively), whereas neither was achieved by sitagliptin (-0.26, p = 0.088; -0.12, p = 0.105). A significantly higher proportion of patients were insulin-free at 12 weeks in the dulaglutide group than in the sitagliptin group (61.5% vs. 20.0%, p = 0.046). As for adverse events, nausea and vomiting were observed in 11.1% of the dulaglutide group. Hypoglycemia was not observed in either group.

Conclusions: Compared with sitagliptin, dulaglutide can be an effective option for glucocorticoid-induced hyperglycemia with acceptable tolerability in real-world clinical settings.

Disclosure

S. Yoshiji: None. Y. Iwasaki: None. K. Iwasaki: None. M. Aizawa-Abe: None. S. Honjo: None. Y. Wada: None. J. Fujikawa: None. A. Hamasaki: None.
1029-P: Teneligliptin Significantly Reduces Liver Fat Content (LFC) and Delays Progression of NASH in Type 2 Diabetes Mellitus Patients
Authors: GUPTA VISHAL KUMAR
Published: June 2019

Nonalcoholic steatohepatitis (NASH) can result in liver cirrhosis and hepatocellular carcinoma (HCC). Several studies have shown that some DPP-4 inhibitors alleviate hepatic steatosis or steatohepatitis in type 2 diabetic mice or rats. We investigated effect of teneligliptin, a DPP-4 inhibitor on patients of type 2 diabetes with NASH.

Methods: 64 patients between ages 18 to 80 years were selected for study. Participants were identified as type 2 Diabetes with biopsy confirmed NASH. All enrolled patients randomized into 2 main groups, on the basis of drugs prescribed to them. GROUP A (n= 34): Teneligliptin 20 mg- Once a day. GROUP B(n=30): Metformin 1000mg Once a day. Patients were analyzed for their fasting, post prandial blood glucose level along with HBA1C value as baseline and followed-up at regular interval of 12 weeks apart till 48 weeks. AST and ALT levels were measured at base line and 12 weeks interval till 48 week. Hepatic steatosis was measured by Transient Elastography (Fibroscan).

Result: As shown in Table.

Conclusion: Result of our study revealed that Teneligliptin significantly reduce serum transaminases and liver fat content (LFC) and delay progression of NASH in type 2 diabetes mellitus patients.

Disclosure

V.K. Gupta: None.
1033-P: Effects of Benaglutide on Weight Loss, Metabolic Changes, and Sexual Hormones in PCOS
Authors: CHEN JINGYAN , SUN QIN , ZHANG MIN , TIAN HAOMING , CHEN SHU
Published: June 2019

Objective: Polycystic ovary syndrome (PCOS) is one the most common metabolic and endocrine disorders in women, which is always accompanied with obesity and insulin resistance (IR). Glucagon-like peptide-1 (GLP-1) has been investigated to decrease body weight and IR in PCOS, and it appears superior combined with metformin (MET) than MET alone. Benaglutide is the first human homologous GLP-1 drug. It had been shown in previous studies to reduce blood glucose and have effect on weight loss. The potential impact of preconception intervention with benaglutide on improving IR and weight loss in PCOS has not been evaluated yet.

Methods: This is a 12-week open-label randomized clinical study.88 overweight/obese (OW/OB) patients with PCOS, who had already received MET 1000 mg Bid treatment for more than 3 months. They were randomized into two groups, to receive either benaglutide (BEN) 0.2 mg ih tid and MET 1000 mg bid (N=35, age: 27.6±5.7, BMI: 28.33±3.36 kg/m2, mean±s.d.) or exenatide (EXE) 10ug ih bid and MET 1000 mg bid (N=33, age: 27.7±6.5, BMI: 28.82±3.44 kg/m2) per day. We observed BMI, OGTT 0- and 2-hour blood glucose, HOMAIR, blood lipids and sexual hormones, at 0 and 12 weeks. Lifestyle intervention was promoted in both groups.

Results: BMI had decreased in the BEN group 1.89±1.55 kg/m2 (p<0.05) compared with 1.83±1.17 kg/m2 (p<0.05) in the EXE group. OGTT 2-hour blood glucose was reduced 0.97±1.80 mmol/l (p<0.05) in the BEN group with 1.43±2.86 mmol/l (p<0.05) in the EXE group. In the BEN group, HOMAIR decreased 1.38±2.86 (p<0.05) as well as in the EXE group 1.61±2.08 (p<0.05), whereas measures of OGTT 0h blood glucose, blood lipids and sex hormones did not change. From all the indexes no significant between-treatment difference (p>0.05) were found in the two groups.

Conclusions: Benaglutide combined with metformin treatment in overweight/obese women with PCOS appears superior decrease in BMI, OGTT 2-hour blood glucose and HOMAIR, the efficiencies were same as exenatide with metformin.

Disclosure

J. Chen: None. Q. Sun: None. M. Zhang: None. H. Tian: None. S. Chen: None.