bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Efficacy of Fipronil, Ivermectin and Clove Oil (Eugenia caryophyllata) against Psoroptes cuniculi Mites in Rabbits (Oryctolagus cuniculus)
Authors: Abdullah O.M. , Durrani U.F. , Mahmood A.K. , Matloob K. , Imran M. , Akhtar R. , Hussain Rashid
Published: March 2021

Background: The present study was conducted to evaluate the therapeutic efficacy of fipronil, ivermectin and clove oil against frequently reported Psoroptes cuniculi mites which are responsible for causing intense pruritus and scab formation on skin, ear pinna and ear canal in domestic rabbits (Oryctolagus cuniculus). Methods: The rabbits were divided into 3 groups viz. A, B and C each having 10 rabbits. These groups were topically treated with fipronil, ivermectin and clove oil on days 0, 7, 14 and 21. Pre and post treatment evaluations were made on the basis of clinical improvement and microscopic examination of skin scrapings in each group. Conclusion: Results revealed that all 3 drugs were effective against P. cuniculi; but ivermectin led recovery was quicker than rest of the two drugs. All three groups were free of lesions and mites on day 21 of treatment.
Estimation of Genetic Parameters, Selection Indices and Association Analysis of Seed Yield and Its Component Traits in Chickpea (Cicer arietinum L.)
Authors: Kumar Amit , Kumar Hitesh , Sharma Vijay , . Kamaluddin
Published: March 2021

Background: Chickpea is a second most important pulse crop grown in 56 countries and India rank first in production which shares 61.4% of the total world chickpea production however, productivity is very low as compared to other countries. Therefore, varietal development with inherent tolerance to biotic and abiotic stress is the prime objective to improve component productivity traits to get better yield in rainfed agro-climatic conditions. Methods: Ninety germplasm accessions of chickpea along with four check viz., JG 14, JG 16, JAKI 9218 and Radhey were evaluated in augmented block design at experimental research farm of Banda University of Agriculture and Technology, Banda, Uttar Pradesh, India. Phenotypic data were subjected to study the genetic parameters and association analysis of yield and its component traits using SPAR 2.0 Package and Windostat Version 9.2. Result: The significant variation was observed for all the traits except number of secondary branches, number of pod per plant, number of seeds per pod among the genotypes. The maximum GCV and PCV was observed for height of first pod (35.28 and 39.29), followed by seed yield per plant (29.77 and 40.32) and number of primary branches (25.63 and 31.44). The high magnitude of heritability with genetic advance was estimated for seed index (96.61%), while the high genetic advance as per cent of mean was recorded for first pod height (65.27%). The positive and significant association of seed yield with number of pods per plant, seed index, number of seeds per pod, number of secondary branches, number of primary branches and height of first pod indicating the importance of these traits in selection criteria. Path analysis identified that number of seeds per pod, number of pods per plants, seed index and number of secondary branches per plant as highly desirable component for direct effect on seed yield per plant. The genotypes ICVT-181106 had highest selection indices for seed yield followed by ICVT-181107, PUSA-1053, JG-218, GNG-1999, ICVT-181102 and HC-5. Therefore, high GCV and PCV, significant positive direct and indirect correlation and high estimate of selection indices for grain yield can be directly and indirectly used for chickpea breeding program.
Prospects and pitfalls associated with implementing blended learning in rural-based higher education institutions in Southern Africa
Authors: Muhuro Patricia , Kangethe Simon Murote , Muhuro Patricia
Published: March 2021

While blended learning is well entrenched in many developed countries as a solution towards enabling access to educational resources and managing student diversity, this may not be the same for rural based universities in developing countries. Yet, blended learning is ideal for the current terrain of the COVID-19 pandemic which requires learning modalities that promote social distancing to reduce the spread of the disease while ensuring that students have access to quality teaching and learning materials and to frequently stay engaged. For many rural based universities, successful blended learning implementation implies an exploration of possible ways to strengthen existing practices. This paper, using the document analysis method, sought to explore the prospects and pitfalls of implementing blended learning in rural- based universities in Southern Africa. The blended learning implementation framework by Graham, Woodfield and Harrison (2013) served as a guiding framework as it was specifically designed to determine success in blended learning adoption and implementation in education. This framework utilises the constructs of strategy, structure and support to differentiate the stages of adopting blended learning. These three stages are in a continuum and comprise awareness and exploration as stage 1, adoption or early implementation as stage 2 and mature implementation and growth as stage 3, with stages differing depending on the extent of formalisation of the institutional strategy, structure and support. Findings indicated prospects of blended learning entail providing opportunities for flexible learning, enabling access to a wide range of educational resources and limiting alienation associated with purely online education delivery. For many institutions, however, implementation of blended learning is still a mirage with the majority still at the first stage of Graham et al.’s (2013) blended learning adoption and implementation framework owing to technical resource constraints related to unstable or non-existent network coverage characteristic in rural locations, curricular deficit stemming from the blended learning model not aligning to context, thus lowering morale for wider implementation. This is exacerbated by weak goodwill and limited policy guidelines on a specific blended learning model. The study concludes that creating conducive conditions for blended learning in rural based universities necessitates a context friendly implementation model where institutional evaluation data inform strategies, support and pedagogical approaches and related resources that can be used locally. The study recommends governmental support for resourcing rural universities to acquire affordable and usable resources to offset challenges hindering blended learning. Rural institutions should also strive to strengthen support to students and staff to build confidence in the potential of blended learning.
The opening and reopening of schools in South Africa during the COVID-19 pandemic: An appraisal from two vantage points
Authors: Van der Walt Johannes (Hannes) , Oosthuizen Izak
Published: March 2021

General legislation as well as legislation specifically regulating education in South Africa is aimed at the protection and advancement of the best interests of children (learners). Developments in the school education sector during the COVID-19 pandemic, which reached the shores of South Africa in March 2020, starkly underscored that not only the interests of the learners were at stake but also those of a variety of other stakeholders such as the parents (-in-organisation), the teachers (-in-organisation), the wider community (civil society) and the state (in the form of, for instance, the Departments of Basic Education and of Cooperative Governance and Traditional Affairs). An examination of the situation in the schooling sector reveals that decisions had to be taken about the opening and reopening of schools in a context of great complexity. This paper examines this complexity from two vantage points, a societal-theoretical and a pedagogical-ethical perspective. The societal-theoretical perspective might help all the role-players to gain a deeper understanding of what their respective roles should be during a crisis: does a situation such as this indeed require a nanny-state (based on the notion of an external locus of control) or should the state allow all those involved to just muddle through the crisis; how should the different role-players interact with one another while confining themselves to their own spheres of competence and respecting those of other parties? The pedagogical-ethical perspective, in turn, might assist the various role-players to understand the ethical dilemmas that tend to surface during a pandemic. The aim of the investigation was to derive guidelines for role-players to find their way through the complexity brought about by a crisis such as a pandemic that seemed to threaten the very fibre of civil life.
Towards a new model for inclusive education based on virtual social inclusion and mobile openness
Authors: Read Timothy
Published: March 2021

The political and social instability in many parts of the world has led to large numbers of refugees forced to find a haven in Europe, and the social and political pressure is felt in these countries, as they see the situation worsening dramatically. In this article, an analysis of the geo-sociological assumptions within the conventional conception of social inclusion is undertaken and substituted by a new one based upon the knowledge-based, network-oriented nature of modern European society. This is referred to as Virtual Social Inclusion (VSI) and it aims primarily at two fundamental dimensions of human activity: education and employment. The article focuses on the nature and implications of VSI for inclusive education and its underlying principles, particularly mobility and openness. What VSI requires to turn from a theoretical framework into a practical reality and the foreseeable implications of its implementation are explored.

Keywords: Virtual social inclusion, social inclusion, MOOC, open education.
The effect of educational digital games on education, motivation and attitudes of elementary school students against course access
Authors: Sabirli Zulkif Eser , Coklar Ahmet Naci
Published: March 2021

The use of computer games is becoming more and more common among children thanks to its many features; from multimedia opportunities to motivation. This increase in its use also increases the importance of educational games. The purpose of this study is to investigate the effect of the use of educational games in education on the academic success, motivation and attitudes of elementary school students. The participants of the research consist of 90 students studying in a public primary school in the 2017-2018 academic years. The research is also important for carrying out with primary school students as younger individuals who are missing in the literature. In the research designed in the quasi-experimental model, an experimental process was carried out with two different units ("In the Classrom" and "Numbers") in the English lesson, and it was observed that the educational games increased the students' access to the lesson. On the other hand, while educational games caused a difference in motivation towards the English lesson, no difference was found in the attitudes towards the lesson.

 

Keywords: Digital game, educational game, motivation, attitude,
Current trends in education technologies research worldwide: Meta-analysis of studies between 2015-2020
Authors: Yildiz Ezgi Pelin , Cengel Metin , Alkan Ayse
Published: March 2021

The interaction of education and technology affects the developments occurring in two areas and the development in education increases the speed of technological developments. Educational technology is the functionalization of the scientific knowledge produced in educational sciences and its application into practice. In this research, the content analysis of the studies conducted in Turkey and other countries in the last 5 years is presented in order to determine the current trends in Educational Technology Research Studies. Within the scope of the purposive sample, the studies published between 2015 and 2020 in the field of Educational Technology Research Studies and included in the databases and journals were examined and interpretations were made. Fifteen research criteria were determined within the context of content analysis. These criteria are as follows: index, country, university, department, year of publication, number of authors, research area, method, educational level, sample group, sample number, data collection method, number of bibliographies, analysis techniques and research trends. SPSS 24 program was used in the analysis of the data and the obtained data were presented in the related tables. The data were interpreted based on percentage and frequency. After making general explanations under the tables, the similarities and differences in the studies were analyzed in detail using a meta-analysis method. As a result, it was revealed that the most emphasized issue within the scope of the research area is the adequacy of using Educational Technologies.

Keywords: Educational technology research, current trends, meta-analysis.
Elementary school children’s speech skills in interdisciplinary ICT communication
Authors: Yesnazar Asel , Japbarov Amangeldi , Zhorabekova Ainur , Kabylbekova Zauret , Nuralieva Artyk , Elmira Uaidullakyzy
Published: March 2021

An analysis of the state of pedagogical practice and scientific and methodological literature speaks of shortcomings in solving the problem of the formation of elementary schoolchildren’s speech skills. This article is devoted to the formation of elementary schoolchildren's speech skills in interdisciplinary communication. The purpose of our experimental work is to verify the effectiveness of our methodology for the sustainable of speech skills in interdisciplinary communication. In preparation for the experimental work, the following objectives were set; to identify the level of formation of speech skills (motivational, informative, reflective), development of a complex of diagnostic methods: observation, questionnaires, diagnostic methods, assessment, self-esteem, etc., on the basis of the data obtained to determine the level of formation of speech skills in interdisciplinary ICT communication. Therefore, the aim of our study is to analyze the state of formation of elementary schoolchildren’s speech skills in interdisciplinary communication. The theoretical significance of the study allows clarifying knowledge on the issue of the formation of speech skills; practical significance lies in the presentation and testing of a set of productive exercises aimed at developing learners' speech skills in interdisciplinary communication. According to the developed diagnostic technique, the formation of speech skills in interdisciplinary communication consists of three components: motivational, substantive and reflective. Based on these components, indicators and levels characterizing the formation of elementary schoolchildren’s speech skills in interdisciplinary communication are distinguished. During the study, the results of a verifying, forming and control experiment were presented. According to the study, we can say that it is necessary to pay attention to the development of meaningful speech, because it is for this indicator that most children are at a low level of formation. On the whole, our study proved that systematic work is needed to form elementary schoolchildren’s speech skills.
 
Keywords: speech skills, interdisciplinary communication, integration, elementary school, formation, criteria, indicators, levels.
The students’ view for teaching numerical analysis in the form of distance education
Authors: Sarikaya Hediye , Yarimsakalli Mehmet Salih
Published: March 2021

With COVID-19 pandemic, which was started in Wuhan, Chine, and is still affecting the whole world as well as our country, education offered distantly. This research aims to determine the students' opinions and their behaviors towards teaching Numerical Analysis in the form of distance education. The research was carried out with a group of students studying at the Faculty of Engineering in a private university in Northern Cyprus during the 2019-2020 academic year. In the research, an interview form was applied to get students’ opinions about distance education and to understand whether it is appropriate to give a numerical analysis course over distance education or not. At the end of the research, students’ positive and negative views about distance education emerged. Most of the students argued the idea that distance education platform is not able to provide education as effectively as the traditional classroom environment. It is supported that it is more accurate to give the form of traditional education because of the application of a Numerical Analysis course is challenging.

Keywords: Distance Education, Numerical Analysis, Student, Distance Learning, Information and Communication
COVID-19 Health Evidence Summary No.115
Authors: Millington Kerry
Published: March 2021

This weekly COVID-19 health evidence summary (HES) is based on 3.5 hours of desk-based research. The summary is not intended to be a comprehensive summary of available evidence on COVID-19 but aims to make original documents easily accessible to decision makers which, if relevant to them, they should go to before making decisions. This summary covers publications on Clinical characteristics and management; Epidemiology and modelling; Infection Prevention and Control; Therapeutics; Vaccines; Indirect impact of COVID-19; Comments, Editorials, Opinions, Blogs, News; Dashboards & Trackers; C19 Resource Hubs; and Online learning & events.
ANALYSE COMPARATIVE DE DEUX MANUELS DE FRANÇAIS LANGUE ETRANGERE SELON LES AXES DE LA PERSPECTIVE ACTIONNELLE
Authors: DÜNDAR Aslı Eda , ASLIM YETİŞ Veda
Published: March 2021

Suite à l’émergence de la perspective actionnelle (PA) plusieurs manuels se déclarant de cette approche sont présents dans l’apprentissage du français langue étrangère. Dans le but d’analyser la conformité des manuels à cette approche nous avons choisi deux manuels : Nouveau Rond-Point Pas à Pas 1 (A1) et Version Originale (A1). Nous avons fait usage de trois questionnaires ; l’un pour les tâches, un pour les projets dans le cadre de la pédagogie du projet et un autre pour l’interculturalité. Selon les résultats obtenus, le manuel Nouveau Rond-Point s’aligne d’avantage aux principes de la PA. Quant au manuel Version Originale, même s’il s’éloigne des principes de façon assez significative et que certains points demandent à être améliorés, il est tout de même assez proche de la PA dans sa généralité.
ÇOCUK ŞİİRLERİNDE SORU, SORGULAMA VE FELSEFİ DÜŞÜNME: MUSTAFA RUHİ ŞİRİN ÖRNEKLEMİ
Authors: SAĞLAM Mehmet Halil
Published: March 2021

Çocuk şiirleri salt pedagojik iletiler üzerine kurgulanmamalı; çocuğun düşünme, sorgulama ve üst bilişsel yetisini de geliştirmelidir. Çocuğun şiiri okurken doğayı, sosyal hayatı, değerleri ve metafizik kavramları sorgulaması önemlidir. Mustafa Ruhi’nin şiirleri bu anlamda dikkat çekici özelliklere sahiptir. Onun şiirlerinde çocukları sürekli sorgulamaya, düşündürmeye ve sentezlemeye yönlendiren soru imgeleri vardır. Çocuk, bu soru imgelerini düşündükçe varlığının farkına varır, içten içe ve içten dışa kozmik âlemi sorgular. Bu çalışmanın amacı çocuk şiirlerinin estetiğe ve felsefeye bakan yönünü ortaya çıkarmaktır. Çalışmadan çıkan sonuca göre, felsefi çocuk şiirleri çocukların eleştirel düşünme yeteneklerini geliştirmekte ve çocuklara estetik haz vermektedir. Bu tür çocuk şiirlerinin arttırılması çocukların kişisel gelişimlerine katkı sağlayacaktır.
ŞİDDET VE TELEVİZYON: ŞİDDETİN TELEVİZYON ÜZERİNDEN DENEYİMLENMESİ
Authors: VATANDAŞ Saniye
Published: March 2021

İnsanın olduğu hemen her yerde şiddet vardır. Çünkü şiddetin faili de çoğunlukla mağduru da insandır. Bu özelliği nedeniyle şiddet, insanlık tarihi ile eşzamanlı olup, insanın sürekli mücadele etmek zorunda kaldığı bireysel ve toplumsal bir olgudur. Önceleri gündelik yaşamın içerisinde birebir deneyimlenen şiddet, kitle iletişim araçlarının yaygınlaşmasıyla, özellikle de sinema, televizyon ve internet mecralarında gündelik yaşamın her anını dolduracak kadar yaygınlık kazanmıştır. Şiddetin açığa çıkması veya yaygınlaşması açısından kitle iletişim araçlarının içerisinde televizyonun ayrıcalıklı bir yeri vardır. Zira internete göre daha uzun bir geçmişe sahip olmasının yanı sıra, sinemaya göre ise daha yaygın ve yoğun izlenen bir araçtır. Bireyler ev ortamında dinlenirlerken bile televizyondaki şiddetin takipçileri durumundadırlar. Televizyondaki şiddet her bireyi etkilemekle birlikte, özellikle çocuklar televizyon karşısında son derece savunmasız konumlarıyla televizyonda izledikleri ve işittikleri şiddet unsurlarını kolaylıkla model durumuna dönüştürebilmektedirler. Bu araştırma televizyonunu şiddetin öğrenilmesi ve yaygınlaşmasındaki rolünü konu edinmektedir.
Plasma midkine levels in patients with cocaine
Authors: Pallardo-Fernández Iñigo , García-Marchena Nuria , Rodríguez-Rivera Carmen , Pavón Francisco Javier , González-Martín Carmen , Rodríguez de Fonseca Fernando , Alguacil Luis F.
Published: March 2021

Preclinical evidence suggests that endogenous midkine could play a key modulatory role on the neurotoxic and addictive effects of different kinds of drugs of abuse, including psychostimulants. However, this hypothesis has not yet been explored in humans. As a first approach to progress in this knowledge, we have comparatively studied plasma midkine levels in 75 patients with cocaine use disorder under abstinence and 26 control subjects matched for sex, age and body mass index. Patients were further segmented into early-abstinent (up to one month of abstinence, n = 30) and late-abstinent (more than one month of abstinence, n = 45). Midkine levels were quantified in plasma samples of all the participants by enzyme-linked immunosorbent assays. Early-abstinent patients exhibited a 60% increase of midkine plasma concentration in comparison with the controls. This elevation tended to normalize upon the progression of abstinence. The results obtained demonstrate that peripheral midkine levels are closely related to cocaine use and are consistent with the idea that this cytokine could play a protective role by limiting the biological activity of psychostimulants.
Clinical practice guideline on pharmacological and psychological management of adult patients with schizophrenia spectrum disorders and a comorbid substance use
Authors: Arranz Belen , Garriga Marina , Bernardo Miquel , Gonzalez-Pinto Ana , Arrojo Manuel , Torrens Marta , Tirado-Muñoz Judith , Fonseca Francina , Saiz Pilar A. , Florez Gerardo , Goikolea Jose Manuel , Zorrilla Iñaki , Cunill Ruth , Castells Xavi , Becoña Elisardo , Lopez Ana , San Luis
Published: March 2021

Although correct diagnosis and management of patients with schizophrenia and a comorbid substance use disorder (SUD) would determine a decrease in morbidity and mortality in these patients, development of efficient therapeutic strategies is still pending. We present recommendations on the pharmacological and psychological management of these patients following the ‘PICO’ structure (Patient-Intervention-Comparison-Outcomes). Evaluation of the quality of studies and summary of the evidence for each question was performed following the recommendations of the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) working group. Our results suggest: 1) In patients with schizophrenia and cannabis use disorder, it is not possible to recommend one antipsychotic drug over another (between olanzapine, risperidone or haloperidol) for improving psychotic symptoms, reducing cannabis use, or improving pragmatic variables (weak recommendation). Clozapine cannot be recommended to reduce cannabis use (weak recommendation). 2) In patients with schizophrenia and cocaine use disorder we recommend haloperidol over olanzapine to reduce craving (moderate recommendation), and olanzapine over haloperidol to improve motor side effects in these patients (moderate recommendation). 3) In patients with schizophrenia and alcohol use disorder while naltrexone is recommended to reduce alcohol use (in terms of reducing alcohol craving) (weak recommendation), there is insufficient evidence to make any recommendation on the use of adjuvant acamprosate (weak recommendation). 4) In patients with schizophrenia and nicotine use disorder, adjuvant bupropion and varenicline are recommended for reducing nicotine use and nicotine abstinence (strong/moderate recommendation). 5) In patients with schizophrenia and polydrug use disorder, second-generation over first-generation antipsychotic drugs and olanzapine over other second-generation antipsychotics are recommended to improve psychotic symptoms (moderate/weak recommendation).
Anxiety sensitivity as a transdiagnostic vulnerability factor for cigarette smoking: Clinical and treatment implications
Authors: López-Núñez Carla , González-Roz Alba , Weidberg Sara , Fernández-Artamendi Sergio
Published: March 2021

Tobacco smoking is the leading preventable cause of premature death worldwide and, despite the fact that many therapies are available for smoking cessation, additional efficacious interventions are needed since many quit attempts are unsuccessful and a high percentage of patients relapse within the months following a quit attempt. In particular, both cigarette consumption and relapse rates among smokers with comorbid mental health problems have shown to be higher than those without them. So far, smoking cessation treatments usually include different approaches aimed at treating specific mental health disorders, particularly anxiety and depression. However, this traditional approach is turning towards a transdiagnostic vulnerability model that includes a set of key clinical factors underlying tobacco use and different emotional conditions, being anxiety sensitivity (AS) increasingly becoming the focus of attention.  Preceding research conducted in United States and Argentina has demonstrated that integrating AS reduction components into broader smoking cessation treatments leads to reduced AS levels as well as improved treatment retention and cessation rates. Nonetheless, there are no published behavioral treatment protocols addressing anxiety and smoking concurrently, or using a transdiagnostic approach for this population, in our country. So far, little is known about the mechanisms underlying the relationship between AS and smoking in Spain. Both clinicians and researchers should focus on explore the AS global construct among Spanish smokers, including the most clinically-relevant variables related to both smoking behavior and smoking cessation, with the purpose of developing novel treatment proposals for quitting.
Repercusión científica de las ayudas de la Delegación del Gobierno para el Plan Nacional sobre Drogas: Publicaciones derivadas e impacto científico
Authors: Aleixandre-Benavent Rafael , Agulló-Calatayud Víctor , Alonso-Arroyo Adolfo , Bueno-Cañigral Francisco-Jesús , Castelló-Cogollos Lourdes , Lucas-Domínguez Rut , Melero-Fuentes David , Sixto-Costoya Andrea , Vidal-Infer Antonio , Valderrama-Zurián Juan-Carlos
Published: March 2021

Los trastornos adictivos son un grave problema de salud al que se destinan gran cantidad de recursos de investigación. El propósito de este trabajo es analizar la evolución e impacto científico de las publicaciones derivadas de las ayudas a proyectos de investigación financiados por el Plan Nacional Sobre Drogas (PNSD). La relación de ayudas concedidas fue proporcionada por el PNSD. Las publicaciones derivadas se obtuvieron preguntando a los investigadores principales de las ayudas y buscando en Web of Science y Scopus. Se calcularon indicadores bibliométricos y tendencias evolutivas de la producción científica por proyecto. Por término medio, el PNSD concedió 15 ayudas anuales a proyectos de investigación, con un importe anual cercano al millón de euros (944.200,64€) y un importe medio por ayuda de algo más de 60.000€, siendo mayor en la investigación básica y en alcohol. El 71,9% de las ayudas tuvieron publicaciones derivadas y casi la mitad produjeron entre una y tres publicaciones, siendo la investigación básica la más prolífica. La revista extranjera en la que más artículos se publicaron fue Psychopharmacology (50) y entre las españolas destacó Adicciones (28). Se identificó un alto índice de coautoría y de colaboración internacional. La mayoría de los proyectos financiados por el PNSD produjeron artículos de investigación y muchos de ellos en revistas del primer y segundo cuartil del Journal Citation Reports. Los resultados de este estudio han permitido conocer la repercusión científica de las ayudas a proyectos de investigación del PNSD y puede contribuir a determinar futuras prioridades de financiación.
Clinical practice guideline on pharmacological and psychological management of adult patients with depression and a comorbid substance use disorder
Authors: Torrens Marta , Tirado-Muñoz Judit , Fonseca Francina , Farré Magi , Gonzalez-Pinto Ana , Arrojo Manuel , Bernardo Miquel , Arranz Belén , Garriga Marina , Sáiz Pilar A. , Flórez Gerardo , Goikolea José Manuel , Zorrilla Iñaki , Cunill Ruth , Castells Xavier , Becoña Elisardo , López Ana , San Luis
Published: March 2021

Co-occurrence of depression and a substance use disorder (SUD) in patients who present dual diagnoses has been long recognized as an important consideration in clinical practice. This review synthesizes the evidence of pharmacological and psychosocial interventions for comorbid depressive disorders and SUDs while providing clinical recommendations about the best interventions to address these patients. The best evidence from randomized controlled trials was used to evaluate treatment options. The strength of recommendations was described using the GRADE approach. Our results suggest that 1) In patients with depression and alcohol consumption, the administration of non-selective serotonin reuptake inhibitor (SSRI) antidepressants instead of SSRI is recommended for improvement of depressive symptoms (strong recommendation). Neither SSRI (strong recommendation) nor non-SSRI (weak recommendation) antidepressants are recommended for reduction in alcohol consumption. 2) In patients with depression and cannabis use, the use of venlafaxine is not recommended (weak recommendation). 3) In patients with depression and cocaine consumption, the use of SSRI antidepressants for improving depressive symptoms (weak recommendation) or to reduce cocaine use is not recommended (strong recommendation). The use of non-SSRI antidepressants is only recommended for improving depressive symptoms (strong recommendation). 4) The administration of bupropion to reduce nicotine consumption is not recommended (strong recommendation). 5) Regarding psychological treatment, in patients with depression and co-occurring alcohol disorder, both pharmacotherapy and cognitive behavioural therapy have positive effects on internalizing symptoms and in reducing alcohol consumption (weak recommendation). Our review suggests the need for more research in this area and for larger, multisite, randomized studies to provide more definite evidence.
Parkinson’s disease after psychosurgery for the treatment of cocaine addiction
Authors: Fuertes-Saiz Alejandro , Correa Mercè , Salamone John , Salais Lidia , Pérez-Saldaña María Teresa , Haro Gonzalo
Published: March 2021

In 2018 we published a clinical case (Haro et al., 2018) of a 32-year-old patient who began to use cocaine at the age of 14 and was diagnosed with “limbic dysfunction syndrome” at 17. The treatment recommended by his psychiatrist was psychosurgery. It was performed in two separate interventions in which radiofrequency-induced thermal coagulation lesions were performed with the aim of deactivating the anterior cingulate cortex (AC), disconnecting it from the ventral striatum and the amygdala in both hemispheres. Shortly after the surgery, the patient began to have delusions and was diagnosed with paranoid schizophrenia. At 27 years of age he was showing cognitive deficits and negative psychotic symptoms.With this letter, two years after the first publication of the case, the authors present the evolution of the patient after the appearance of a probable late complication of psychosurgery. New neuroimaging data, neurological evaluation and discussion conducted from a translational point of view are included.
Diagnóstico imagenológico de conductos obliterados: Una revisión.
Authors: Morales-González Francisco Javier
Published: March 2021

Los exámenes radiográficos son de gran ayuda para que el endodoncista diagnostique y realice planes de tratamiento eficientes en sus  pacientes. Hasta hace unos años, las proyecciones en 2 dimensiones, principalmente las radiografías periapicales, eran utilizadas para la planeación de casos endodóncicos de conductos obliterados; sin embargo, en la actualidad, el empleo de la tomografía computarizada de haz cónico (TCHC) es la herramienta más precisa y su uso cada vez es más frecuente, específicamente en casos de obliteración del canal radicular.Aunque todavía no se tienen datos sobre alguna técnica clínica que permita la localización exacta del canal calcificado, se sabe que, en situaciones de endodoncia muy complicadas, el uso intraoperatorio de TCHC puede ayudar al endodoncista a obtener un diagnóstico más adecuado, a garantizar un procedimiento eficaz y, por lo tanto, a conseguir resultados más acertados después del tratamiento. Recientemente, la endodoncia guiada y navegada se ha considerado como procedimiento alternativo al tratamiento convencional que ofrece una solución a los casos de conductos parcial o totalmente obliterados. Debido a que es necesario considerar la preservación de la estructura y la retención a largo plazodel diente después del tratamiento endodóncico, es importante mencionar que las endodoncias guiadas y las navegadas presentan una considerable reducción de lesiones iatrogénicas, como menores complicaciones durante la localización de obliteración en el conducto radicular. Por este motivo, el objetivo de esta revisión fue describir el estado del arte del diagnóstico imagenológico de los conductos obliterados, con las técnicas actuales más novedosas.
Carbonate Caprock–Brine–Carbon Dioxide Interaction: Alteration of Hydromechanical Properties and Implications on Carbon Dioxide Leakage
Authors: Sang Guijie , Liu Shimin
Published: March 2021

Caprocks play a crucial role in the geological storage of carbon dioxide (CO2) by preventing its escape and thus trapping it into underlying sequestering reservoirs. An evaluation of interaction-induced alteration of the hydromechanical properties of caprocks is essential to better assess the leaking risk and injection-induced rock instability, thus ensuring a long-term viability of geological CO2 storage. We study the changes in minerals, nanopores, elastic velocities, and mechanical responses of a carbonate caprock caused by rock–water/brine–CO2 interaction (CO2 pressure: ≈12 MPa; 50°C). Before the interaction, the total and accessible porosities are 1.6 and 0.6%, respectively, as characterized by the small-angle neutron scattering (SANS) technique. SANS results show that the total porosity of the carbonate caprock increases, apparently because of rock–brine–CO2 interaction, and the increasing rate rises as brine concentration increases (2.2% for 0 M NaCl, 2.6% for 1 M NaCl, and 2.7% for 4 M NaCl). The increase in total porosity is due to the dissolution of calcite, which tends to enlarge accessible pores (by 0.8 to 1.2%) while slightly decreasing the inaccessible pores (by 0.1–0.2%). Under a CO2–acidified water environment, the compressional-wave (P-wave) and shear-wave (S-wave) velocities (5536.7 and 2699.7 m/s) of a core sample containing natural fractures decrease by 8.5 and 8.1%, respectively, whereas both P- and S-wave velocities (6074.1  and 3858.8 m/s) for an intact sample show only ≈0.5% decreases. The interaction also causes more than 50% degradation of the uniaxial compressive strength for the core sample with natural fractures. X-ray microcomputed tomography experiments on three tiny cores (diameter: 1 mm) after 5-day treatment with CO2 (12 MPa) also show that matrix erosion occurs under CO2–acidified water environment but barely occurs without a direct contact with liquid water. Our study suggests that the hydromechanical properties of carbonate caprocks could evolve over the long-term CO2–brine invasion, and it is critical to monitor the CO2–acidified brine interface for a better and long-term evaluation of the caprock integrity.
Multi-walled Carbon Nanotubes/Manganese Dioxide Nano- flowers-like/Polyaniline Nanowires Nanocomposite Modified Electrode: A New Platform for a Highly Sensitive Electrochemical Impedance DNA Sensor
Authors: Chu Tuan , Tran Luyen Thi , Tran Hoang Vinh , Tran Trung , Nguyen Nghia Trong , Bui Dan , Tran Phu Quang
Published: March 2021

We describe in this report a development of label-free electrochemical DNA sensor based on a novel nanostructured electrode of multi-walled carbon nanotubes (MWCNTs)/ nano-flowers-like manganese dioxide (MnO2)/polyaniline nanowires (PANi NWs) nanocomposite. The nanocomposite was synthesized in-situ onto an interdigitated platinum microelectrode (Pt) using a combination of chemical and electrochemical synthesis methods: chemical preparation of MWCNTs/MnO2 and electropolymerization of PANi NWs. The fabricated MWCNTs/MnO2/PANi NWs was then used to develop a label-free electrochemical DNA sensor for a specific gene of Escherichia coli (E.coli) O157:H7 detection. The MWCNTs/MnO2/PANi NWs modified Pt electrode’s surface can facilitate for probe DNA strands immobilization and, therefore the electrochemical signal of the DNA sensors has been improved. The electrochemical impedance spectroscopy (EIS) measurements were conducted to investigate the output signals generated by the specific binding of probe and target DNA sequences. Obtained results indicated that the developed electrochemical biosensor can detect the target DNA in the linear range of 5 pM to 500 nM with a low limit of detection (LOD) at 4.42 × 10 –13 M. The research results demonstrated that the MWCNTs/MnO2/PANi NWs nanocomposite-based electrochemical DNA sensor has a great potential application to the development of highly sensitive and selective electrochemical DNA sensors to detect pathogenic agents.
Optimierungsparadoxien
Authors: Wolf Eike , Thiersch Sven
Published: March 2021

Der Diskurs zur Integration digitaler Medien in der Schule bewegt sich aktuell zwischen Optimierungsnarrativen einerseits und deren Kritik andererseits. Der Beitrag geht der mikroperspektivischen Frage nach, wie digitale Medien im Unterricht interaktiv eingebettet sind und ob überhaupt bzw. in welcher Hinsicht sich ihr Einsatz auf die pädagogische Interaktionspraxis optimierend zeigt. Auf der Grundlage der Auswertung von Beobachtungs- und Interaktionsprotokollen aus dem Projekt «Zur sozialen Praxis digitalisierten Lernens» werden folgende typische Optimierungspraktiken des digital mediatisierten Unterrichts im Spannungsfeld von Transformation und Reproduktion systematisiert und präsentiert: die Koordination von Rederechten und Sozialformen, die Herstellung von Transparenz und individueller Sichtbarkeit und die (Selbst-)Aktivierung respektive Beteiligung von Schülerinnen und Schülern. Es wird gezeigt, dass mit den technischen Möglichkeiten der Vereinfachung und Steuerung der Unterrichtsinteraktion nicht intendierte Nebenfolgen einhergehen, die in der pädagogischen Interaktion zu bearbeiten sind. Mit dem Versuch einer «technologischen Lösung» und Modifikation unterrichtlicher Handlungsprobleme verlagert und verschärft sich die Komplexität und Kontingenz des Unterrichts und konsolidiert paradoxerweise die antinomisch verfasste Struktur pädagogischer Sozialität.
Zum optimierenden Geist der digitalen Bildung
Authors: Leineweber Christian , Wunder Maik
Published: March 2021

Im vorliegenden Beitrag werden die Begriffe der Effizienz, Berechenbarkeit, Vorhersagbarkeit und Kontrolle als Operationalisierung für einen zeitgemässen Optimierungsbegriff herangezogen. Es wird dargelegt, inwiefern ein so verstandener Optimierungsbegriff sich gegenwärtig auf gesellschaftlicher Ebene, auf der des subjektiven Handelns sowie auf der Ebene digitaler Lernarrangements einschreibt und verfestigt. Bildungstheoretisch wird diese Beobachtung kritisch reflektiert, indem vor allem auf das Element der Unverfügbarkeit abgestellt wird. Bildung wird damit als Geschehen kenntlich gemacht, das sich einem optimierenden Geist des Digitalen entzieht.
Foreign experience of providing communication in state agencies
Authors: Biletska G. , Кovtunovych N. , Shkurenko N.
Published: March 2021

The article is devoted to practical aspects of implementation of communication strategies by the state agencies of foreign countries. The emphasized that current globalization processes in the information area, which take place in the international arena, actualize the introduction of effective communications, which play an important role in the internal and external interaction of state agencies with the public. In the article was emphasized that in order to systematically and clearly cover the activities of state agencies, as well as the objective perception and understanding of the population of the processes implemented in the field of public policy, informing the public about planned government initiatives, communication strategies are actively implemented. Also noted that in the countries of the European Union (hereinafter – the EU) communications are considered by the national institutions as a tool for foreign and security policy, international cooperation in the format of strategic partnership with a leading international target audience and regional cooperation with European countries. The authors determined the main tasks of realization of external and internal communications of state institutions. In particular, the ways of realization of communications by the state agencies in Norway, Great Britain and Estonia. The preference of modern advanced information communications in ensuring the interaction of state agencies and the public are outlined. As today society exists in the world of global communication, which includes not only traditional media, periodicals or television, but also social networks, information and communication interaction is becoming more important. Most foreign countries use popular social networks, such as Facebook, Twitter, Instagram, YouTube and others. It is concluded that the establishment of comprehensive, clear and strategic communication of state authorities of Ukraine with the international and national community, taking into account foreign experience and basic principles of government communication, is important for building a democratic state.
Video S2.mp4
Authors: Prinsloo Earl , Hundling Jethro
Published: March 2021

Example of motion of resin based prototype bioprinter.
Educational environment – the territory of schoolchildren
Authors:   Saratov State University, Demina Olga
Published: March 2021

The current situation in secondary education is characterized by the development of various educational institutions, which differ not only in educational programs and curriculum, but also in the conditions for training and educating, which make up the educational environment of modern educational institutions. The importance of studying the processes of forming the educational environment in a modern school is relevant, since the quality of education and upbringing of modern students who spend most of their time in the educational environment of schools will depend on its organization. Studying the problems of organizing the educational environment is also important in the sense that it is the qualitative approach to this process that will determine in the future if it is possible for students to receive high-quality educational services. The influence of the educational environment on the modern student is determined today, first of all, by the students' perception of the educational process, their involvement in the process of its creation and improvement. The effectiveness of the educational environment may also depend on how the student perceives it. So, the educational environment can be an effective means of developing the potential of the student, but if it is an integrated space for the interaction of children and adults (parents, teachers).
Modern tasks upbringing teenagers and young people in a socio-cultural context
Authors:   Moscow State Academy of Choreography (Moscow), Olenev Svyatoslav , Skvortsov Konstantin ,   Russian State University of Transport (Moscow)., Ying Zhang ,   Moscow State Academy of Choreography (Moscow).
Published: March 2021

The article deals with modern problems of improving educational work with modern Russian teenagers and young people who are experiencing negative effects of the consequences of long-term social instability and the loss of social guidelines for spiritual and moral development. The purpose of the article is to determine the current and modern directions of educational work with adolescents and young people. Research methods are analysis of sources, analysis and generalization of modern practical experience of pedagogical and socio-pedagogical activities, including the experience of the authors themselves. The authors identify the main characteristic features of modern socio-cultural problems of education of adolescents and young people, causing the need to change the strategy of educational activities. These problems are rooted in the absence of a coherent national idea supported by society, without which the constructive theses of the "Fundamentals of the state youth policy of the Russian Federation for the period up to 2025" are poorly integrated into educational practice. The authors prove the significance of the problem of social and civic passivity, the lack of psychological and pedagogical support for personal self-determination in society, spontaneous cultural practices of adolescents and young people, and the decrease in their motivation for socially significant goals, priorities of professional and personal growth. The article determines significance of shifting existing decisions and initiatives about the career guidance into a practice-oriented, rather than formal. The authors provide some factual information about the insufficiently high level of communicative culture of many teachers, which hinders effective educational work with adolescents and youth, often causing conflicts and provoking a nihilistic attitude of adolescents and youth to the directed educational process. The authors prove the need to abandon the formal attitude of the pedagogical community to educational work, the importance of correcting the priorities of education, applying new ideological incentives, creating a system of psychological and pedagogical support for self-determination and strengthening the aesthetic education of adolescents and young people. The authors render the need to create a fundamentally new psychovaleological direction of educational work with adolescents and young people in the pedagogical process of educational institutions and in a broad socio-pedagogical context.
Deducing dimensions of quality education among the world’s top universities
Authors:   Institute for Research in Innovative Instructional Delivery, Cebu Normal University, Cebu, Philippines, et al. Boholano
Published: March 2021

Higher education institutions invasions to deliver quality education at all levels at all times. World ranking universities are good in research, publication, and international partnership. This study aims to deduced dimensions of quality education among the world’s top-ranking universities. Findings revealed that top-ranking universities are good in research and provide quality teaching performance. Quality education is the pursuit of building an academic reputation, research influence, and industry reputation. Research-based teaching and learning increased academic performance. Thus, there are different dimensions of quality education in the universities.