bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacologic PPAR-γ activation reprograms bone marrow macrophages and partially rescues HSPC mobilization in human and murine diabetes
Authors: Admin Ada , Tedesco Serena , Ciciliot Stefano , Menegazzo Lisa , D’Anna Marianna , Scattolini Valentina , Cappellari Roberta , Cignarella Andrea , Avogaro Angelo , Albiero Mattia , Fadini Gian Paolo
Published: April 2020

Mobilization of hematopoietic stem/progenitor cells
(HSPCs) from the bone marrow (BM) is impaired in diabetes. Excess oncostatin M
(OSM) produced by M1 macrophages in the diabetic BM signals through p66Shc to
induce Cxcl12 in stromal cells and
retain HSPCs. BM adipocytes are another source of CXCL12 that blunts
mobilization. We tested a strategy of pharmacologic macrophage reprogramming to
rescue HSPC mobilization. In vitro,
PPAR-γ activation with pioglitazone switched macrophages from M1 to M2, reduced
Osm expression, and prevented
transcellular induction of Cxcl12. In diabetic mice, pioglitazone treatment downregulated Osm, p66Shc and
Cxcl12 in the hematopoietic BM, restored the effects of granulocyte-colony
stimulation factor (G-CSF), and partially rescued HSPC mobilization, but it
increased BM adipocytes. Osm deletion
recapitulated the effects of pioglitazone on adipogenesis, which was
p66Shc-independent, and double knockout of Osm and p66Shc completely rescued
HSPC mobilization. In the absence of
OSM, BM adipocytes produced less CXCL12, being arguably devoid of
HSPC-retaining activity, whereas pioglitazone failed to downregulate Cxcl12
in BM adipocytes. In diabetic patients under pioglitazone therapy, HSPC
mobilization after G-CSF was partially rescued. In summary, pioglitazone reprogrammed
BM macrophages and suppressed OSM signaling, but sustained Cxcl12 expression by BM adipocytes could limit full recovery of HSPC
mobilization.
Изучение гемодинамики легочных вен и левого предсердия у пациентов с фибрилляцией предсердий методом 4D Flow. Результаты пилотного исследования
Authors: Glazkova E.IU. , Makarenko V.N. , Aleksandrova S.A. , SHliappo M.A. , Darii O.IU.
Published: April 2020

Цель.Выявить гемодинамические изменения в легочных венах (ЛВ) и левом предсердии (ЛП) у пациентов с фибрилляцией предсердий (ФП) с использованием возможностей метода магнитно-резонасной томографии (МРТ) 4D Flow. Материал и методы.Магнитно-резонансная томография сердца по программе 4D Flow выполнена 8 пациентам без патологии сердечно-сосудистой системы (контрольная группа (КГ)) и 7 пациентам с ФП (группа ФП). Всем пациентам рассчитаны гемодинамические параметры в каждой из четырех ЛВ, проведен анализ кровотока в ЛП с оценкой вихреобразного потока вортекса в три фазы предсердного цикла. Результаты.У пациентов с ФП достоверно снижены параметры кровотока в ЛВ (Mе Q1 Q3): пиковой линейной скорости кровотока 35,8 см/с 23,3 44,0 против 41,4 36,1 53,7 в группе контроля (р 0,002), ударного объема ЛВ 12,75 мл 8,3 18,6 против 18,2 13,7 21 в КГ (р0,014), градиента давления 0,3 мм рт. ст. 0,2 0,6 против 0,6 0,5 0,9 в КГ (р0,002), объемной скорости кровотока в ЛВ 30,0 мл/с 18,6 42,0 против 40,9 32,4 51,0 в КГ (р 0,021). В группе ФП чаще определяется прямолинейный ток крови из правых ЛВ в полость ЛП (100 пациентов против 25 в КГ) (р0,004) и десинхронизация изменения скоростей кровотока между ЛВ (71 пациентов против 12 в КГ) (р0,025) реже формируются вортексы ЛП в резервуарную фазу (р0,04), в кондуитную (р0,001) и насосную (р0,032). Выводы.Работа демонстрирует возможности нового метода 4D Flow МРТ в оценке изменений гемодинамики ЛВ и ЛП у пациентов с ФП. У пациентов с ФП выявляется снижение показателей кровотока ЛВ, десинхронизация кровотока между ЛВ и реже формируются вортексы в ЛП. Диагностическая ценность этих критериев как факторов риска тромбоэмболических осложнений требует дополнительных исследований.
Показания, критерии, выбор метода реваскуляризации миокарда: данные европейских и российских клинических рекомендаций
Authors: Sigaev I.IU. , Keren M.A.
Published: April 2020

В обзоре представлена современная тактика хирургического ведения пациентов со стабильной ишемической болезнью сердца в различных клинических ситуациях. Рассмотрены стандарты лечения данной нозологии, представлены некоторые положения новых европейских рекомендаций по реваскуляризации миокарда (2014 г.) и российских показаний к реваскуляризации миокарда (российский согласительный документ) (2011 г.). Использование клинических рекомендаций в повседневной клинической практике дает возможность определить основные направления диагностики и варианты хирургического лечения. В статье рассматриваются вопросы стратификации рисков проведения реваскуляризации миокарда, информирования пациента, стратегии предоперационного обследования, а также определения показаний к реваскуляризации и выбору ее метода. Особое внимание уделено пациентам с коморбидными состояниями (сахарным диабетом, мультифокальным атеросклерозом). Также рассмотрены страте- гии наблюдения и ведения пациентов после реваскуляризации миокарда.
Heart team. Когда привлекаем онколога?
Authors: Barbarash O.L.
Published: April 2020

В статье представлены современные взгляды на ведение пациентов с сердечно-сосудистой и онкологической патологиями. Обозначены наиболее спорные вопросы по проблемам подготовки пациентов с сердечно-сосудистой патологией к некардиологическим (онкологическим) оперативным вмешательствам. Обсуждены существующие ограничения в диагностике, профилактике и лечении кардиотоксичности химиотерапии при лечении злокачественных образований. Представлены перспективы научных исследований, направленных на оценку единых механизмов развития сердечно- сосудистых и онкологических заболеваний.
Optimasi Dashboard Information System Stikom Bali Dengan Algoritma Levenshtein Distance
Authors: Sumiari Ni Kadek , Ari Jayanti Ni Ketut Dewi
Published: April 2020

Kebutuhan data dan informasi bagi perguruan tinggi sangatlah penting salah satunya adalah bagi para eksekutif. Pada perguruan tinggi data dan informasi diperlukan untuk membuat dokument keperluan akreditasi atau sebagai pelaporan tahunan pada Rapat Tinjauan Manajemen (RTM). Untuk mempermudah eksekutif dalam memperoleh informasi data yang akurat maka keberadaan Dashboard Information System dalam perguruan tinggi cukup penting. STMIK STIKOM Bali merupakan salah satu perguruan tinggi yang sudah menerapkan Dashboard Infromation System bagi para eksekutif untuk memperoleh data dari semua system informasi yang sudah terintegrasi. Melalui Dashboard Information System Eksekutif STMIK STIKOM Bali dapat melihat informasi data yang realtime. Dashboard Infromation System STMIK STIKOM Bali dirancang menggunakan metode analisa FAST (Framework for the Application of Sistem Thinking) serta dibangun berbasis web dengan bahasa pemrograman PHP dan framework bootstrap. Pada Dashboard Infromation System pencarian data merupakan salah satu fungsi penting. Agar pencarian data lebih optimal maka perlu diterapkan sebuah algoritma untuk pencarian data. Pada Dashboard Infromation System STMIK STIKOM Bali diimplementasikan algoritma levenshtein distance untuk optimasi dalam pencarian data. Hasil setelah diimplemnatsikan algoritma levensthein distance pada Dashboard Infromation System adalah terdapat rekomendasi terdekat kata apabila user salah dalam melakukan input data sehingga pencarian lebih optimal. Kata Kunci — Dashboard Information System, Optimasi, Levenshtein Distance Data requirements and information on universities are very large, especially for management executives. In higher education the data and information needed to make documents are in accordance with the annual management report. To facilitate communication in using the right information data and Information System Dashboard Information in higher education is quite important. STMIK STIKOM Bali is one of the universities that has implemented an Information System Dashboard for executives to obtain data from all integrated information systems. Through the Executive Dashboard Information System STMIK STIKOM Bali can see real-time data information. Dashboard Information System STMIK STIKOM Bali will use the FAST analysis method (Thinking System Application Framework) and build web-based with PHP and bootstrap framework. On the Information System Dashboard look for data for one important function. In order to search data more optimally it is necessary to apply an algorithm to find data. In the STMIK STIKOM Bali Dashboard Information System levenshtein distance algorithm is implemented for optimization in data search. The results after implementing the Levensthein distance algorithm on the Information System Dashboard are one of the most complete of user errors in performing optimal data input. Keywords — Dashboard Information System, Optimization, Levenshtein Distance
Implementasi Metode Bayes untuk Menentukan Potensi Diri Beserta Pengaruhnya Terhadap IPK Mahasiswa
Authors: Jasuma Agung , Kusrini Kusrini , Arief M Rudyanto
Published: April 2020

Tingginya minat siswa untuk melanjutkan sekolah ke jenjang yang lebih tinggi berpengaruh pada tingginya jumlah mahasiswa yang terdaftar di Indonesia. Kesulitan dalam menyelesaikan perkuliahan menjadi masalah yang sering terjadi, salah satu penyebabnya adalah ketidak-sesuaian potensi diri dengan program studi yang dipilih. Penelitian ini menjadikan FIK Universitas Amikom Yogyakarta sebagai tempat studi kasus untuk mencari tahu korelasi potensi diri dengan IPK mahasiswa, mencari potensi diri terbaik pada masing-masing program studi serta mencari tahu akurasi metode naive bayes dalam mengklasifikasi potensi diri mahasiswa. Responden yang digunakan dalam penelitian ini berjumlah 50 orang yang terdiri dari mahasiswa minimal semester 4, alumni dan 1 pakar. Pengumpulan data menggunakan metode wawancara dan koesioner, sedangkan pengolahan data menggunakan metode naive bayes classifier, confusion matrix untuk pengujian, dan korelasi pearson product moment untuk mencari tahu ada tidaknya korelasi. Penelitian ini mendapatkan hasil bahwa potensi diri kemampuan logika, visual dan interpersonal berpengaruh terhadap tingginya IPK mahasiswa dimana nilai signifikansi logika=0.043<0.05, interpersonal=0,029<0.05 dan visual=0,05<0.05. Kemampuan logika cenderung akan berdampak baik pada IPK mahasiswa prodi S1-SI, S1-IF, serta S1-TK, sedangkan kemampuan visual berdampak baik pada program studi S1-TI, D3-MI dan D3-IF. Naive bayes juga diketahui memiliki tingkat akurasi sebesar 90,625% dalam mengklasifikasikan mahasiswa berdasarkan potensi diri. Kata Kunci — bayes, IPK, mahasiswa The high interest of students to continue their education has an effect on the high number of students in Indonesia. Difficulties in completing lectures become a problem that often occurs, one of the reasons is incompatibility study program and student talents. This research made FIK Amikom University Yogyakarta as a case study to find out the correlation of Grade Point average (GPA) and student talents, best talents that’s needed in each study program and the accuracy of naive bayes in classifying students' talents, 50 people consisting of students at least semester 4, alumni and 1 expert as respondents. Data collection uses interview and questionnaire methods, while data processing uses the naive bayes classifier, confusion matrix for testing, and Pearson product moment correlation to find out whether there is correlation. This study found that the self-potential logic, visual and interpersonal abilities influence the high GPA of students where the significance value of logic=0.043<0.05, interpersonal=0.029<0.05 and visual=0.05<0.05. Logical ability tends to have a good impact on the GPA of S1-SI, S1-IF, and S1-TK study program, while visual abilities have an impact on S1-TI, D3-MI and D3-IF. Naive Bayes is also known to have an accuracy rate of 90.625% in classifying students based on their talents. Keywords — bayes, GPA, students
Perancangan Sistem Klasifikasi Penyakit Jantung Mengunakan Naïve Bayes
Authors: Bianto Mufti Ari , Kusrini Kusrini , Sudarmawan Sudarmawan
Published: April 2020

Serangan Jantung adalah salah satu penyakit yang paling mematikan tercatat di dunia, terdapat jumlah kasus baru Penyakit Jantung sebanyak 43,32% serta jumlah kematian sebanyak 12,91%. Pada tahun 2013 jumlah penderita Penyakit Jantung di Indonesaia sejumlah 61.682 orang, pada umumnya jumlah penderita penyakit ini terus meningkat dikarenakan kurangnya pengetahuan atau informasi tentang penyakit jantung tersebut, oleh karena itu dibutuhkan sebuah sistem yang dapat memberikan informasi serta klasifikasi penyakit secara dini yang dapat digunakan untuk klasifikasi apabila seseorang ingin mengetahui informasi ataupun gejala awal serangan jantung. Metode naïve bayes merupakan salah satu metode yang digunakan untuk melakukan klasifikasi berdasarkan probabilitas atau kemungkinan dari data sebelumnya, selain pendekatannya sederhana metode tersebut juga dapat melakukan klasifikasi secara baik. Mekanisme pengujiannya yaitu membagi 303 data kedalam 5 subset yang akan divalidasi dengan 5-fold cross validation. Hasil akhir dari penelitian ini adalah penerapan sistem klasifikasi dengan menggunakan metode naïve bayes yang akan menghasilkan nilai rata-rata akurasi sebesar 90,61%, presisi sebesar 87,44 %, dan recall sebesar 87,95%. Kata Kunci — klasifikasi, penyakit jantung, naïve bayesClassifier Heart attack is one of the most deadly diseases recorded in the world, there are a number of new cases of heart disease as much as 43.32% and the number of deaths as much as 12.91%. In 2013 the number of sufferers of heart disease in Indonesia amounted to 61,682 people, in general the number of sufferers of this disease continues to increase due to lack of knowledge or information about heart disease, therefore we need a system that can provide information and classification of diseases early that can be used for classification if someone wants to find out information or early symptoms of a heart attack. Naïve Bayes method is one of the methods used to classify based on the probability or likelihood of previous data, in addition to a simple approach the method can also do a good classification. The testing mechanism is to divide 303 data into 5 subsets that will be validated by 5-fold cross validation. The final result of this study is the application of the classification system using the Naïve Bayes method which will produce an average accuracy value of 90.61%, a precision of 87.44%, and a recall of 87.95%. Keywords — classification, heart disease, naïve bayes
An Improved Image Segmentation System
Authors: Allioui Hanane , Sadgal Mohamed , El Fazziki Aziz
Published: April 2020

In this paper, we present a solution-based cooperation approach for strengthening the image segmentation.This paper proposes a cooperative method relying on Multi-Agent System. The main contribution of this work is to highlight the importance of cooperation between the contour and region growing based on Multi-Agent System (MAS). Consequently, agents’ interactions form the main part of the whole process for image segmentation. Similar works were proposed to evaluate the effectiveness of the proposed solution. The main difference is that our Multi-Agent System can perform the segmentation process ensuring efficiency. Our results show that the performance indices in the system were higher. Furthermore, the integration of the cooperation paradigm allows to speed up the segmentation process. Besides, the tests reveal the robustness of our method by proving competitive results. Our proposal achieved an accuracy of 93,51%± 0,8, a sensitivity of 93,53%± 5,08 and a specificity rate of 92,64%± 4,01.
Methodological Foundations for Testing the Level of Motivation and Labor Satisfaction of Young Engineers and Technicians
Authors:   Rostov State Transport University, Uvarov Ivan Aleksandrovich
Published: April 2020

This study proposes a methodology for testing young engineers and technicians for motivation and labor satisfaction, which are low at Russian enter-prises. The methodology combines the advantages of other methods, and also takes into account the features of these professional and age groups. In particular, features of young engineers and techni-cians’ needs have been taken into account. The structure of the test (the number of questions, an-swer options, their wording, the number of points distributed) are compiled with mathematical and psychological justification for this case. The differ-ence between the intensity and importance of the need is taken into account as well. The necessary transformations were made to verify the truth of the statements of the respondents. Based on this, a mathematical data processing algorithm was com-piled to match quantitative indicators to the logical meaning of the questions. Validation of the formula, considering the characteristics of this category of workers, was carried out according to Pearson's criterion and showed a high degree of reliability.
The Features of the Investigation of Cybercrimes
Authors:   Russian Presidential Academy of National Economy and Public Administration, Ryvkin Stanislav Yuryevich , Huseynov Tofik Azerovich ,   Russian Presidential Academy of National Economy and Public Administration
Published: April 2020

Continuing the research on the topic “Doctrinal pro-visions of procedural, search-cognitive, tactical ac-tions in the investigation of crimes that led to the death of military personnel, through the prism of practical innovations in military-applied criminalis-tics”, the authors note and analyze the features of the investigation of cybercrimes, including commit-ted in armed groups. The concepts and essential structures of cyber-digital weapons, the possibilities of making additions to regulatory acts in the inves-tigation of cyber attacks are being studied. It is indi-cated that a cybercrime is basically defined as any criminal activity that is carried out using the Internet with the use of information technology. Such ele-ment of the criminalistic characteristics of cyber-crime is highlighted as the power of cyber-digital weapons. The paper considers the features of inves-tigative situations during the preliminary investiga-tion of cybercrimes: secrecy of the mechanism of crime, the possibility of forensic trolling.
THE EFFECTS OF TECHNOSTRESS CREATORS AND ORGANIZATIONAL COMMITMENT AMONG SCHOOL TEACHERS
Authors: Hassan Narehan , Yaakob Siti Aisyah , Mat Halif Mazuin , Abdul Aziz Rozilah , Abdul Majid Afiza , Sumardi Nur Athirah
Published: April 2020

In the fast-paced world, information is retrieved and stored efficiently using IT technologies. Due to the constant change and advancement in technology, technostress has become a critical issue in many organizations especially for those who are IT illiterate. This scenario is especially true for school teachers in Malaysia where students’ information is stored and retrieved using a database system and posted online for quick accessibility of files and student management. However, for those who are not IT-skilled, this type of work demand can influence both the employee’s motivation and work commitment. School teachers in Malaysia are found to be overworked and most had to take home their work, especially in updating students’ information. The changing work demands and the need to perform both teaching and administrative duties have resulted in teachers facing a stressful working environment. This is especially true for senior teachers, whose IT skill is often lagging compared to their younger counterparts; hence the term technostress is coined -- not only to teachers but to those who are lacking in IT-related skills. Teachers’ commitment is of utmost importance to produce better workforce for the future. Hence, this study was conducted to examine both the relationship and the effects of techno-stress creators and organizational commitment among school teachers. This study was carried out at six schools in Selangor involving 173 school teachers.  The findings revealed that two dimensions of techno-stress creators which were techno-uncertainty and techno-insecurity had positive and significant influence on organizational commitment while all other three elements of techno-stress creators which were techno-overload, techno-invasion and techno complexity did not predict teachers’ organizational commitment. The findings also revealed that certain amount of techno-stress can enhance the level of teachers’ commitment.
Promoting Empathy Using Design Thinking in Project-Based Learning and as a Classroom Culture
Authors: Md Hashim Adila , Syed Aris Sharifah Ruzaina , Chan Yuen Fook
Published: April 2020

This paper explores the benefits of empathy skill for school students. The encouragement of empathy skill in school was discussed in two situations: 1. Using design thinking approach for project-based learning and 2. Promoting as a classroom culture. Empathy is an act of understanding, being conscious and experiencing the feeling and thoughts of other people. It is the key to inspire social innovation and diminishing prejudice against others. Empathy skill has affected our feeling of wellbeing and human centeredness to provide an understanding of people’s needs. By integrating design thinking process in school, students will equip themselves with empathy-related skills such as communication, observation, decision-making and positive relationship with others as part of their active learning process. Adapting design thinking in project-based learning requires students to be aware and concern in exploring human-driven design which leads to user satisfaction for any problem’s solution. Empathy also has the advantage of forming a positive classroom culture and sustaining a good teacher-student relationship. This paper discussed how the design thinking process can promote empathy skill during project-based learning for humanizing decision-making and the opportunity for empathy integration in the classroom to engage in positive collaboration and teamwork.

 

KEYWORDS: Classroom Culture, Design Thinking, Empathy, Project-Based Learning
STEM Integration: Factors Affecting Effective Instructional Practices in Teaching Mathematics
Authors: Mohd Rasid Nor Syazwani , Md Nasir Nurul Akmal , A/l Aperar Singh Parmjit Singh , Cheong Tau Han
Published: April 2020

Malaysian Ministry of Education (MOE) has created initiatives in the Malaysian Education Blueprint (2013- 2025 that aim to increase teachers’ and students’ competencies in Science, Technology, Engineering and Mathematics (STEM) subjects and create learning experiences that will prepare students for the considerable array of STEM career fields. There are so many effective instructional practices suggested in integrating STEM education for teaching Mathematics. However, there are some factors that need to be concerned in producing effective instructional practices in teaching Mathematics. This study investigated the factors affecting instructional practices of mathematics since the implementation STEM education. Using a descriptive design method, a questionnaire was administered to 100 students and 50 mathematics teachers in Klang Valley. The overall mean score of all four factors (Lesson plan and implementation, Mathematical discuss and sensemaking, task implementation, and classroom culture) measured in this study is moderately high based on students’ and teachers’ perspectives. Teachers rated all factors higher than students’ rate. Both teachers and students agreed that classroom culture is the important factor. There are no significant differences in the mean score of factors among gender of students and teachers. There is a significant difference in the mean score of factors among the achieving abilities among the students.

Keywords: STEM Education, Mathematics, Lesson plan, Task, Classroom culture, Mathematical discuss
M-Track: Progress Tracking System for MOOC Development
Authors: Md Noor Harrinni , Aziz Anealka
Published: April 2020

In 2014, the Ministry of  Education initiated Massive Open Online Course (MOOC) pilot project at public universities in Malaysia. Universiti Teknologi MARA (UiTM) was selected among three public universities to develop the university’s own MOOC.  This pilot project is one of the initiatives by the Malaysian government to support the ninth shift of Malaysia Education Blueprint 2015 – 2025 (Higher Education): Globalized Online Learning, which is introduced to achieve the desired outcomes set by the National e-Learning Policy (Dasar e-Pembelajaran Negara or DePAN). All MOOCs are now available on the Open Learning platform and offered throughout the year. It is a huge task indeed to manage and monitor simultaneous MOOC development in all UiTM faculties and state campuses. Thus, a tracking system to monitor the progress of MOOC development by lecturers called the M-Track System was designed. This paper explains how the system was developed and implemented. The system facilitates e-learning administrators to monitor the quality of MOOC at all 26 faculties and 12 UiTM campuses throughout Malaysia before there were offered to the public.The system can generate several types of report and this ensures the duration of MOOC development is adhered to. The target users of the system are the MOOC developers, MOOC Coordinators, MOOC Managers at the institution and anyone who wishes to develop MOOC.

Keywords: MOOC tracking, MOOC development, MOOC monitoring, MOOC reporting
Sinopse de Artigos Mais Relevantes em Arritmias Cardíacas
Authors: Papelbaum Bruno
Published: April 2020

Sinopse de artigos
Rational Use of Leads in Artificial Cardiac Pacing
Authors: Eduardo Duarte Carlos , Brambilla Sbaraini André
Published: April 2020

Introduction: Cardiovascular implantable electronic device (CIEDs) are a proven therapy for the treatment of bradyarrhythmias, prevention of sudden death or heart failure. Since the first transvenous pacemaker implantation more than 60 years ago, technological advances in devices and improvements in surgical techniques have occurred. However, this type of therapy is still associated with significant complications, most of them related to the implantation of transvenous leads. Objective: To present a reflection on how to practice the rational use of lead implantation and propose strategies and alternatives to delay or avoid it, based on the current knowledge in the various fields of artificial cardiac stimulation. Methods: Review of literature that used articles from 1995 to 2019, from several platforms and periodicals. Conclusion: There is an expectation that in the coming years there will be technological and knowledge advances in the field of leadless stimulation, allowing these devices to be incorporated into clinical practice in a routine manner. Currently, if the implantation of ventricular electrodes in cases of sinus node disease with preserved atrioventricular conduction is rationalized, the implantation of atrial electrodes in implantable cardioverter-defibrillators (ICD) without the necessity of antibradicardia stimulation or ventricular electrodes in cases without the necessity of antitachycardia stimulation (ATP) considering the subcutaneous ICD implantation, this article will have fulfilled its role.
Uso Racional dos Cabos-Eletrodos na Estimulação Cardíaca Artificial
Authors: Eduardo Duarte Carlos , Brambilla Sbaraini André
Published: April 2020

Introdução: Os dispositivos cardíacos eletrônicos implantáveis (DCEIs) são terapia consagrada para o tratamento de bradiarritmias, prevenção de morte súbita ou insuficiência cardíaca. Desde o primeiro implante de marcapasso transvenoso há mais de 60 anos, ocorreram avanços tecnológicos dos dispositivos e melhorias nas técnicas cirúrgicas. No entanto esse tipo de terapia ainda está associado a complicações significativas, a maioria relacionada ao implante dos cabos-eletrodos transvenosos. Objetivo: apresentar uma reflexão sobre como praticar o uso racional do implante de cabos-eletrodos e propor estratégias e alternativas para postergá-lo ou evitá-lo, com base nos conhecimentos atuais nos diversos campos da estimulação cardíaca artificial. Métodos: Revisão da literatura que utilizou artigos de 1995 a 2019, de diversas plataformas e revistas. Conclusão:Há a expectativa de que nos próximos anos ocorram avanços tecnológicos e de conhecimento no campo da estimulação leadless, permitindo que esses dispositivos sejam incorporados na prática clínica de maneira rotineira. Atualmente, se o implante de eletrodos ventriculares nos casos de doença do nó sinusal com condução atrioventricular preservada for racionalizado, o implante de eletrodos atriais nos cardiodesfibriladores implantáveis (CDI) sem necessidade de estimulação antibradicardia ou dos eletrodos ventriculares nos casos sem a necessidade de estimulação antitaquicardia (ATP) considerando o implante de CDIs subcutâneos, este artigo terá cumprido o seu papel.
Cardiomyopathy Induced by Artificial Heart Stimulation
Authors: dos Santos Galvão Filho Silas
Published: April 2020

With the advent of cardiac pacemakers more than 60 years ago, the era of artificial cardiac pacing began, which changed the natural history of symptomatic bradycardias, significantly increasing the survival especially of patients with complete atrioventricular block.
PSYCHOPATHY
Authors: COOKE David J.
Published: April 2020

Psychopathy is an important forensic construct. Psychopathic personality disorder has long been recognized as an important forensic construct. It has relevance for violence, treatability and manageability. It is a construct that can have a disproportionate influence on decision making and ethical forensic practice requires practitioners to take cognizance of the limitations of our current assessments.
STUDYING THE PROCEDURE COMPONENT OF LEARNING MOTIVES OF STUDENTS WITH DIFFERENT GPA
Authors: KELOYAN Mari
Published: April 2020

The article focuses on the study of the procedural component of students' learning motives from the faculties of humanities of ASPU. As an academic task has been taken reading comprehension, and reading comprehension actions have been considered as procedural components of learning motives.

The focus group method was chosen as an effective method for studying the above-mentioned issue. The results of the focus group study, that's the variety of reading comprehension actions of students with different GPA (Grade Point Average) were revealed and grouped. The actions or strategies of medium and especially low GPA students are poor for ensuring deep comprehension of academic texts, which in its turn decreases learning motivation, while students with high-GPA mainly perform mental actions of different complexity levels for ensuring text comprehension which in turn increases intrinsic learning motivation.
Promosi Perpustakaan Melalui Instagram: Studi di Perpustakaan Universitas Airlangga
Authors: Suharso Putut , Pramesti Aninda Nurwindu
Published: April 2020

Artikel berisi tentang bagaimana promosi perpustakaan lewat media sosial Instagram. Interaksi antara pustakawan dengan pemustaka saat ini bisa dilakukan secara virtual dengan memanfaatkan teknologi informasi yang ada. Peneliti secara khusus mengamati salah satu akun perpustakaan perguruan tinggi yaitu Universitas Airlangga. Bagaimana berkomunikasi dengan pemustaka lewat Instagram merupakan salah satu cara yang efektif dalam melakukan sebuah promosi di perpustakaan perguruan tinggi. Artikel ini juga melihat bagaimana bentuk-bentuk interaksi yang ditawarkan aplikasi Instagram dan bagaimana pihak Perpustakaan Universitas Airlangga menggunakan fasilitas yang terdapat di Instagram Itu sendiri. Metode pengambilan data melalui observasi di akun Instagram Universitas Airlangga dan melakukan studi pustaka yang telah ada. Kajian ini dilakukan secara intensif selama 3 (tiga) bulan, yaitu dari bulan Agustus - Oktober 2019 untuk melihat bagaimana perpustakaan melakukan promosi perpustakaan lewat Instagram. Hasil dari kajian yang kami lakukan perpustakaan Airlangga telah memanfaatkan semua fasilitas yang ada di Instagram dalam melakukan promosi perpustakaan. Perpustakaan telah menggunakan Fasilitas Instagram Story, Upload Video, upload Foto, bahkan melakukan Live Instagram guna melakukan promosi perpustakaan
Odwarstwienie nabłonka barwnikowego – diagnostyka multimodalna w codziennej praktyce klinicznej – część druga
Authors: Kucharczuk Jan , Lahutta-Kordys Katarzyna
Published: April 2020

Odwarstwienie nabłonka barwnikowego jest częstą patologią występującą w różnych chorobach siatkówki. Rozpoznanie to jest używane bardzo często, ale nie zawsze w prawidłowym znaczeniu i bez wyraźnego rozróżnienia między jego typami. Odmienna patogeneza i typ zmian wiążą się z charakterystycznymi cechami w badaniu angiografii fluoresceinowej, autofluorescencji, spektralnej koherentnej tomografii optycznej i badaniu angiograficznym opartym na koherentnej tomografii optycznej. W niniejszym artykule spróbujemy zwrócić uwagę na istotne elementy stosowanej w codziennej praktyce klinicznej diagnostyki multimodalnej tej patologii, pozwalające prawidłowo określić jej typ, naturalny przebieg oraz postępowanie terapeutyczne.
Choroby odzwierzęce w okulistyce. Część 2. Zespół larwy wędrującej ocznej
Authors: Borkowski Piotr
Published: April 2020

Toksokaroza oczna, właściwie zespół larwy wędrującej ocznej, to choroba pasożytnicza oka, której przyczyną są obcogatunkowe larwy glist, najczęściej psiej (Toxocara canis), które przypadkowo zawędrowały do gałki ocznej. Jest to rzadka choroba, ale druga z infekcyjnych przyczyn zapalenia tylnego odcinka błony naczyniowej w Polsce (11,8%). Dostępne komercyjnie w Polsce badania dodatkowe, które możemy zastosować w tej jednostce chorobowej, mają ograniczone znaczenie, więc rozpoznanie powinno być kliniczne. W artykule tym zebrano dane z literatury z uwzględnieniem jej nowych pozycji, na temat epidemiologii, przebiegu klinicznego, rozpoznawania oraz współczesnych zasad leczenia toksokarozy ocznej opisane z punktu widzenia specjalisty chorób zakaźnych i pasożytniczych praktycznie zajmującego się chorobami oczu od ponad 20 lat.
Usos exploratórios e sustentáveis da natureza no entorno do Parque Nacional da Serra do Itajaí em Indaial-SC
Authors: Santos Gilberto Friedenreich dos , Garrote Martin Stabel
Published: April 2020

O estudo trata das relações sociedade e natureza para compreender os usos exploratórios e sustentáveis da natureza das comunidades localizadas na zona de amortecimento (ZA) e entorno do Parque Nacional da Serra do Itajaí (PNSI), especificamente no município de Indaial, Vale do Itajaí (SC). O objetivo da pesquisa é investigar a história dos usos dos recursos naturais da natureza antes e após a criação do PNSI em 2004. Trata-se de uma pesquisa exploratória de caráter histórico baseada em fontes bibliográficas, especialmente regionais, e o acervo de transcrições e áudios de entrevistas do grupo de pesquisa. A identificação de iniciativas de usos sustentáveis nas comunidades consistiu na aplicação de questionários com proprietários de empreendimentos. A atividade de campo inclui a observação da paisagem para identificar o processo de ocupação e uso dos recursos naturais. Até a década de 1980 o desenvolvimento das comunidades associava-se basicamente à agricultura e exploração madeireira. A partir de 1990, leis ambientais proíbem a exploração da Mata Atlântica e rompem um período de intensa exploração. A criação do PNSI consolida o processo de proteção da biodiversidade e dos recursos hídricos na região, que favorece a conservação dos atrativos naturais e propiciam o desenvolvimento de empreendimentos e atividades de lazer.
Palavras-chave: Parque Nacional da Serra do Itajaí. Comunidades de entorno. Indaial. Uso exploratório. Desenvolvimento Sustentável.
Análise comparativa de lucratividade das culturas de erva-mate em relação a soja no Planalto Norte Catarinense
Authors: Pedrassani Daniela , Knop Marisa Liller , Perciak Jamile
Published: April 2020

Diante da importância das culturas de erva-mate e soja no Planalto Norte de Santa Catarina faz-se essencial um estudo dos valores de custos e o retorno financeiro da produção de erva-mate como forma de diversificar a propriedade, tornando-a mais lucrativa. O desenvolvimento de uma ferramenta de consulta para tomada de decisões em relação a diversificação de culturas e comparativos, traz aos agricultores e investidores rurais, um instrumento auxiliar para a tomada de decisão baseada em valores reais médios de acordo com a região e realidade. Deste modo, o objetivo foi analisar a lucratividade obtida com o cultivo de erva-mate e comparar com a obtida com o cultivo de soja em área agrícola na região do Planalto Norte Catarinense. A pesquisa foi do tipo quantitativa, exploratória e descritiva. Realizou-se a análise financeira do Valor Presente Líquido (VPL). Os resultados indicaram que num período de 10 anos das duas atividades, a erva-mate, apesar de requerer maior tempo entre o investimento e o retorno econômico, foi superior financeiramente. A cultura da erva-mate tem seu retorno de investimento no quinto ano após o plantio. A soja mantém lucratividade a cada safra, necessitando investimentos para produção anual, já a erva-mate, há investimento maior no primeiro ano, e diminui os investimentos a partir do segundo ano, apenas para manter as plantas em crescimento, e estabilizando a produção no nono ano. Conclui-se que a erva-mate tem retorno financeiro superior em relação à soja.
Palavras-Chave: Análise Financeira. Agricultura. Rentabilidade. Desenvolvimento Regional.
F-wave parameters for the tibial nerve in Miniature Dachshunds with and without naturally acquired thoracolumbar intervertebral disk herniation
Authors: Okuno Seiichi , Orito Kensuke
Published: April 2020

OBJECTIVE

To determine values of F-wave parameters for the tibial nerve in clinically normal Miniature Dachshunds and those with thoracolumbar intervertebral disk herniation (IVDH).

ANIMALS

53 Miniature Dachshunds (10 clinically normal and 43 with various clinical grades of thoracolumbar IVDH).

PROCEDURES

F-waves were elicited in the interosseous muscles of 1 hind limb in each dog by stimulation of the tibial nerve. F-wave parameters were measured for 32 stimuli/dog, and mean values were calculated. Linear regression was performed to assess correlations between F-wave parameters and clinical severity of IVDH.

RESULTS

For clinically normal dogs, mean ± SD values of shortest F-wave latency, mean F-wave conduction velocity, mean F-wave duration, and ratio of the mean F-wave amplitude to M response amplitude were 8.6 ± 0.6 milliseconds, 83.7 ± 6.1 m/s, 6.6 ± 1.5 milliseconds, and 9.8 ± 8.5%, respectively. F-wave persistence was 100%. Mean F-wave duration was positively correlated with clinical grade of IVDH. Linear regression yielded the following regression equation: F-wave duration (milliseconds) = 6.0 + 2.7 × IVDH grade. One dog with grade 2 IVDH had a mean F-wave duration shorter than that of all 5 dogs with grade 1 IVDH; 1 dog with grade 3 IVDH had a longer duration than that of all 10 dogs with grade 4 IVDH.

CONCLUSIONS AND CLINICAL RELEVANCE

Mean F-wave duration was correlated with the severity of inhibitory motor tract dysfunction in the spinal cord of dogs. F-wave examination may be useful for objective functional evaluation of upper motor neurons in the spinal cord.
Some additional records to the inventory of dragonflies and damselflies (Odonata) in Andalas University’s Limau Manis campus complex, Padang, West Sumatra
Authors: JANRA MUHAMMAD NAZRI , HERWINA HENRY
Published: April 2020

Since the publication of inventory list for dragonflies and damselflies within the boundary of Andalas University’s Limau Manis Campus Complex, Padang, on 2018, the survey efforts have been continuously conducted. Hence, in this article we add five odonate species new for Andalas University’s Limau Manis Campus Complex, with one species Drepanosticta cf. bispina may require further investigation and elaboration on its existence in West Sumatra. We also corrected the identification of Heliocypha fenestrata into H. angusta angusta. With this addition, Andalas University’s Limau Manis Campus Complex currently resides for 32 species and 9 families of Odonata, increasing from previously 27 species and 8 families.
Potential side effects of medicine on patients with tuberculosis fixed-dose combination in dr. Pirngadi Hospital, Medan
Authors: DASOPANG EVA SARTIKA , HASANAH FENNY , FAUZIAH IDA , SALMAN SALMAN , BAKRI TEDY KURNIAWAN
Published: April 2020

Tuberculosis is caused by the bacterium Mycobacterium tuberculosis, which by only using a few new antibiotics, can kill the bacteria. Tuberculosis treatment has several stages, namely intensive and advanced stages. Compliance with the use of OAT is an imported factor in the success of TB treatment. The use of many drugs can cause side effects that result in patients stopping treatment when it creates the TB treatment process to fail. Improved adherence can do by using a fixed-dose combination OAT. In the intensive phase, the patient will get a fixed-dose combination containing a mixture of four antibiotics. The purpose of this study is to evaluate the potential side effects that occur during fixed-dose combination OAT treatment at an intensive stage and see the level of compliance of patients taking TB drugs. Observational sampling in TB patients was taking OAT at an acute stage by looking at side effects that arise during treatment and then analyzed using statistics and algorithm Naranjo. The results showed the most common potential side effects for fixed-dose combination OAT in the intensive stage were itching, headache and nausea with a percentage of 72% each, joint pain 45%, stomach pain 36.4%, lack of appetite and rashes 27.3% each and reddish color in the urine 18.2%. The results of the analysis using Naranjo logarithm obtained results eight, which means the side effects might cause due to the use of the drug. The results of patient compliance achieved a 100% compliance rate
Molecular taxonomy of Indopiptadenia oudhensis (Brandis) Brenan (Leguminosae - Mimosoideae) - A threatened endemic monotypic genus
Authors: Dhakad Ashok Kumar , Pandey Vijay Vardhan , Kumar Rahul , Thakur Ajay , Chandra Anup , Barthwal Santan
Published: April 2020

Indopiptadenia oudhensis (Brandis) Brenan is a threatened and an endemic legume forest tree genus of tropical moist deciduous forest of lower foothills of Himalaya. As population status of the species is declining at alarming rate, molecular characterization and germplasm conservation is urgently needed. This is the first attempt to draw its phylogeny based on molecular level and evolutionary closeness with other legumes. Among three barcode genes i.e rbcL, matK and ITS, only rbcLaF-rbcLaR gave satisfactory amplification and proved that rbcL is still working well than other barcode genes and justifies the evolutionary affinities with other legume species. Based on nucleotide homeology, the species is closely related to Prosopis cineraria and demonstrated nucleotide variation at only one site (552; A>G). Based on rbcL gene sequences and phylogeny, its evolutionary linkages found similar to the species placed in subfamilies Mimosaoideae and Caesalpiniodeae. However, researchers working on legume phylogeny clearly mentioned that Indopiptadenia is a part of clade mimosoid of Caesalpinioideae based on morphology. Hence, Indopiptadenia oudhensis may be the connecting species between subfamilies Mimosaoideae and Caesalpiniodeae.
GC–MS analysis of ethanolic leaf extract of Capparis divaricata Lam.
Authors: Hemalatha M. , Korlam Saivenkatesh , Yasodamma N.
Published: April 2020

Planet earth is rich in plant-based medicine. Unfortunately, most of the medicinal plants are not in lime light for their optimal utilisation by the mankind mostly, because of unknown medicinally important phytochemicals present in them. Capparis divaricata Lam. is one of the medicinally important plants widely distributed in Arthagiri Hills of Chittoor Dist., Andhra Pradesh. The plant is ethnobotanically used for different ailments especially cancer. In the present study, Gas Chromatography and Mass Spectrometry (GC-MS) analysis of leaf ethanolic extract of Capparis divaricate is reported. Octasilaxone, Hexadecamethyl; Acetoxymethyl – Trimethyl: Octamethyl were identified as the major compounds.  Further, these compounds may act as anti-cancerous agents by efficient pharmacological studies.
The principles of liberal internationalism in diplomatic reality of Lester B. Pearson
Authors: Pokrovskaia Daria Mikhailovna
Published: April 2020

The subject of this research is the practice of liberal internationalistic approach to foreign affairs, which form many decades is a defining factors in studying Canada’s foreign policy. The Canadian liberal internationalism emerged after the World War II, and the concept of its ideology received its development in the 1950’s being inextricably linked to the name of Lester Pearson. The object of this research is the views, ideas and main approaches of Lester Pearson, who held a post of Undersecretary of State and later Prime Minister of Canada, towards the formation of foreign policy of the country. Methodology contains the analysis of personal sources of Lester Pearson and his colleagues, public speeches, official documents of Canadian Department of Foreign Policy, as well as writings of the leading Russian and foreign scholars. The author highlights the key principles of the liberal internationalistic approach towards conducting Canada’s foreign policy, among which is the institutional approach, participation of Canada in world politics as a “medium superpower”, mediation in settlement of international disputes, peacekeeping activity and adherence to the ideas of collective security, etc. A detailed analysis is carried out on the personal views and techniques of conducting diplomacy of Lester Pearson that influences the development of the Canadian liberal internationalism.
THE OCCUPY ESTELITA MOVEMENT AND SILENCING IN PERNAMBUCO JOURNALISM
Authors: Figueiredo Carolina Dantas , Cavalcanti Juliana
Published: April 2020

This paper investigates the press in the state of Pernambuco and its silencing of the Occupy Estelita movement by analyzing journalistic coverage on the occupation of the José Estelita pier. An examination was conducted between May and June of 2014 on how the voices for the Occupy Estelita movement were silenced in the journalistic coverage from the three main journals in Pernambuco: Folha de Pernambuco, Diario de Pernambuco and Jornal do Commercio. At a time when traditional media are experiencing a crisis in their business model and information is increasingly horizontal, we reflect on the silencing of the Occupy Estelita movement in the Pernambuco press.Este artigo se propõe a investigar o silenciamento da imprensa pernambucana no caso do Movimento Ocupe Estelita, a partir da análise da cobertura jornalística realizada durante a ocupação do terreno do Cais José Estelita. Entre maio e junho de 2014, diagnosticou-se como a voz do Movimento Ocupe Estelita foi silenciada na cobertura jornalística dos três principais jornais pernambucanos: Folha de Pernambuco, Diario de Pernambuco e Jornal do Commercio. Em um momento em que os meios tradicionais de comunicação vivem uma crise de modelo do negócio e no qual a informação é cada vez mais horizontal, avalia-se aqui os reflexos do silenciamento do tema Ocupe Estelita na pauta da imprensa pernambucana.Este trabajo propone investigar lo silenciamiento realizado por la prensa del estado de Pernambuco en el que se refiere a el caso del Movimento Ocupe Estelita, tomando como referencia el análisis de la cobertura periodística realizada durante la ocupación del terreno del Cais José Estelita. Entre mayo y junio de 2014, fue realizado un diagnóstico de cómo la voz de Movimento Ocupe Estelita fue silenciada en la cobertura periodística de los tres principales periódicos de Pernambuco: Folha de Pernambuco, Diario de Pernambuco y Jornal do Commercio. En un momento en que los medios tradicionales experimentan una crisis de modelo de negocio y en que la información es más horizontal, evaluamos los reflejos de lo silenciamiento del caso Ocupe Estelita en la prensa de Pernambuco.