bluuebunny/crossref_metadata_2025 huggingface dataset:
Massively Parallel CFD Simulation Software: CCFD Development and Optimization Based on Sunway TaihuLight
Authors: Liu Xiazhen , Lu Zhonghua , Yuan Wu , Ma Wenpeng , Zhang Jian
Published: July 2020

A parallel framework software, CCFD, based on the structure grid, and suitable for parallel computing of super-large-scale structure blocks, is designed and implemented. An overdecomposition method, in which the load balancing strategy is based on the domain decomposition method, is designed for the graph subdivision algorithm. This method takes computation and communication as the limiting condition and realizes the load balance between blocks by dividing the weighted graph. The fast convergence technique of a high-efficiency parallel geometric multigrid greatly improves the parallel efficiency and convergence speed of CCFD software. This paper introduces the software structure, process invocations, and calculation method of CCFD and introduces a hybrid parallel acceleration technology based on the Sunway TaihuLight heterogeneous architecture. The results calculated by Onera-M6 and DLR-F6 standard model show that the software structure and method in this paper are feasible and can meet the requirements of a large-scale parallel solution.
Change of Outpatient Oral Surgery during the COVID-19 Pandemic: Experience of an Italian Center
Authors: Bennardo Francesco , Antonelli Alessandro , Barone Selene , Figliuzzi Michele Mario , Fortunato Leonzio , Giudice Amerigo
Published: July 2020

COVID-19, which appeared to originate in China in December 2019, has spread worldwide in a pandemic way. The aim of this work is to present a protocol to standardize the outpatient oral surgery activities through remote triage, diagnostic tests, protections, and precautions that allow to provide care while minimizing risk for both patients and surgeons. This article summarizes the clinical and surgical experience of the Oral Surgery Unit of the “Mater Domini” Hospital (Magna Graecia University of Catanzaro, Italy) during the COVID-19 pandemic. The application of a scrupulous triage protocol, the use of remote consultations to limit patients’ access to the clinic, and the correct use of PPE prevented transmission of the virus between patients and staff members.
Effects of Irreducible Fluid Saturation and Gas Entry Pressure on Gas Production from Hydrate-Bearing Clayey Silt Sediments by Depressurization
Authors: Ma Xiaolong , Sun Youhong , Guo Wei , Jia Rui , Li Bing
Published: July 2020

Gas hydrates in the Shenhu area are mainly hosted in clayey silt sediments, which have the relatively high irreducible fluid saturation and gas entry pressure. And then, they will have an impact on gas production from hydrate-bearing clayey silt sediments, which was evaluated by the numerical simulations of SH2 site in Shenhu area in this paper. The results showed that, with the increase in irreducible water saturation and irreducible gas saturation, the amount of water production and gas production was obviously reduced. When the irreducible water saturation increased from 0.10 to 0.50, the cumulative CH4 production volume decreased from 1668799 m3 to 1536262 m3, and the cumulative water production volume dropped from 620304 m3 to 564797 m3, respectively. When the irreducible gas saturation increased from 0.01 to 0.05, the cumulative CH4 production volume dropped from 1812522 m3 to 1622121 m3, and the cumulative water production volume dropped from 672088 m3 to 600617 m3, respectively. In addition, the capillary pressure increased obviously with the increase in gas entry pressure, but the effect on gas production was small and the effect on water production could be negligible. In conclusion, irreducible water and gas saturation had an important effect on the gas production from gas hydrate, whereas the effects of gas entry pressure could be ignored.
Optimization for Due-Window Assignment Scheduling with Position-Dependent Weights
Authors: Wang Li-Yan , Lv Dan-Yang , Zhang Bo , Liu Wei-Wei , Wang Ji-Bo
Published: July 2020

This paper considers a single-machine due-window assignment scheduling problem with position-dependent weights, where the weights only depend on their position in a sequence. The objective is to minimise the total weighted penalty of earliness, tardiness, due-window starting time, and due-window size of all jobs. Optimal properties of the problem are given, and then, a polynomial-time algorithm is provided to solve the problem. An extension to the problem is offered by assuming general position-dependent processing time.
Study on the Fractal Characteristics of Coal Body Fissure Development and the Law of Coalbed Methane Migration of around the Stope
Authors: Yang He , Liu Zhen , Zhu Danliang , Yang Wenzhi , Zhao Dawei , Wang Wendi
Published: July 2020

Due to the complicated coalbed methane (CBM) occurrence conditions and the diverse geological structures in China, the promotion and application of the coal and gas simultaneous extraction technology have been seriously restricted. In view of this, this paper chooses Qingdong Coal Mine protection layer mining and CBM extraction field practice as the research background. Firstly, based on the similar material simulation experiment that simulates coal mining, the dynamic changing pattern of a mining field’s overburdened strata and corresponding stress are obtained, the relationship between gas desorption and stress can then be clarified. Further, with the help of the fractal theory and box counting method, the fracture development characteristics of the overlying strata are quantitatively described on the basis of experimental images. Finally, by building a model for calculating the penetrability coefficient of coal seam based on fractal dimension of mining fissure and analyzing the relationship between fissure development and fractal dimension, the gas migration law and the fissure development areas of #7 and #8 overburden strata where CBM concentrates can be revealed and determined. According to the orientation of the area mentioned above, the location of the CBM pumping field in relation to the coal seam roof and the arrangement of CBM extraction boreholes can be optimized, which make CBM extraction efficient. Meanwhile, the risk of coal and gas outburst is significantly reduced when the CBM concentration is controlled within 0.2% to 0.6% outside the corner of the working face and 0.1% to 0.35% in return flow, which is lower than 0.8%, the threshold of CBM concentration.
P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors
Authors: Romagnani Andrea , Rottoli Elsa , Mazza Emilia Maria Cristina , Rezzonico-Jost Tanja , De Ponte Conti Benedetta , Proietti Michele , Perotti Michela , Civanelli Elisa , Perruzza Lisa , Catapano Alberico L. , Baragetti Andrea , Tenedini Elena , Tagliafico Enrico , Falzoni Simonetta , Di Virgilio Francesco , Norata Giuseppe Danilo , Bicciato Silvio , Grassi Fabio
Published: July 2020

Extracellular ATP (eATP) is a signaling molecule that variably affects all cells of the immune system either directly or after hydrolysis to adenosine. Although eATP is virtually absent in the interstitium of normal tissues, it can be present in the hundreds of micromolar range in tumors, a concentration compatible with activation of the ATP-gated ionotropic P2X7 receptor. Here, we show that P2X7 activity in tumor-infiltrating lymphocytes (TIL) induces cellular senescence and limits tumor suppression. P2X7 stimulation affected cell cycling of effector T cells and resulted in generation of mitochondrial reactive oxygen species and p38 MAPK-dependent upregulation of cyclin-dependent kinase inhibitor 1A (Cdkn1a, encoding for p21Waf1/Cip1). Lack of P2X7 promoted a transcriptional signature that correlated with enhanced cytotoxic T-cell response in human solid tumors. In mice, transfer of tumor-specific T cells with deletion of P2rx7 significantly reduced tumor growth and extended survival. Collectively, these findings uncover a purinergic checkpoint that can be targeted to improve the efficacy of cancer immunotherapy strategies.

Significance:

These findings suggest that the purinergic checkpoint P2X7 may be targeted to enhance T-cell–mediated cancer immunotherapy and improve T effector cell accumulation in the tumor microenvironment.
Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy
Authors: Nowicki Theodore S. , Farrell Colin , Morselli Marco , Rubbi Liudmilla , Campbell Katie M. , Macabali Mignonette H. , Berent-Maoz Beata , Comin-Anduix Begoña , Pellegrini Matteo , Ribas Antoni
Published: July 2020

Transgenic T-cell receptor (TCR) adoptive cell therapies recognizing tumor antigens are associated with robust initial response rates, but frequent disease relapse. This usually occurs in the setting of poor long-term persistence of cells expressing the transgenic TCR, generated using murine stem cell virus (MSCV) γ-retroviral vectors. Analysis of clinical transgenic adoptive cell therapy products in vivo revealed that despite strong persistence of the transgenic TCR DNA sequence over time, its expression was profoundly decreased over time at the RNA and protein levels. Patients with the greatest degrees of expression suppression displayed significant increases in DNA methylation over time within the MSCV promoter region, as well as progressive increases in DNA methylation within the entire MSCV vector over time. These increases in vector methylation occurred independently of its integration site within the host genomes. These results have significant implications for the design of future viral vector gene–engineered adoptive cell transfer therapies.

Significance:

Cellular immunotherapies' reliance on retroviral vectors encoding foreign genetic material can be vulnerable to progressive acquisition of DNA methylation and subsequent epigenetic suppression of the transgenic product in TCR adoptive cell therapy. This must be considered in the design of future generations of cellular immunotherapies for cancer.

This article is highlighted in the In This Issue feature, p. 1611
Analyses of Intermediate-Stage Hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization prior to Designing Clinical Trials
Authors: Koroki Keisuke , Ogasawara Sadahisa , Ooka Yoshihiko , Kanzaki Hiroaki , Kanayama Kengo , Maruta Susumu , Maeda Takahiro , Yokoyama Masayuki , Wakamatsu Toru , Inoue Masanori , Kobayashi Kazufumi , Kiyono Soichiro , Nakamura Masato , Kanogawa Naoya , Saito Tomoko , Kondo Takayuki , Suzuki Eiichiro , Nakamoto Shingo , Yasui Shin , Tawada Akinobu , Chiba Tetsuhiro , Arai Makoto , Kanda Tatsuo , Maruyama Hitoshi , Kato Jun , Kuboki Satoshi , Ohtsuka Masayuki , Miyazaki Masaru , Yokosuka Osamu , Kato Naoya
Published: July 2020

Background: Intermediate-stage hepatocellular carcinoma (HCC) has a high frequency of recurrence and progression to advanced stage after transarterial chemoembolization (TACE), particularly in patients with high tumor burden. Promising new results from immune checkpoint inhibitors (ICIs) and ICI-based therapies are expected to replace TACE, especially in HCC patients with high tumor burden. Aims: The present study aimed to evaluate the effectiveness of TACE with a view to design clinical trials comparing TACE and ICIs. Methods: We retrospectively identified intermediate-stage HCC patients undergoing TACE from our database and subdivided patients into low- and high-burden groups based on three subclassification models using the diameter of the maximum tumor and the number of tumors. Clinical outcomes were compared between low- and high-burden intermediate-stage HCC. Results: Of 1,161 newly diagnosed HCC patients, 316 were diagnosed with intermediate-stage disease and underwent TACE. The median overall survival from high-burden intermediate-stage disease was not significantly different by clinical course, reaching high tumor burden in all subclassification models. The prognosis of high-burden patients after initial TACE was poor compared with low-burden patients for two models (except for the up-to-seven criteria). In all three models, high-burden patients showed a poor durable response rate (DRR) both ≥3 months and ≥6 months and poor prognosis after TACE. Moreover, patients with confirmed durable response ≥3 months and ≥6 months showed better survival outcomes for high-burden intermediate-stage HCC. Conclusions: Our results demonstrate the basis for selecting a population that would not benefit from TACE and setting DRR ≥3 months or ≥6 months as alternative endpoints when designing clinical trials comparing TACE and ICIs.
The Prevalence of Diabetes and Pre-Diabetes among the Dubai Population: Findings from Dubai Household Health Surveys, 2014 and 2017
Authors: Alawadi Fatheya , Hassanein Mohamed , Suliman Eldaw  , Hussain Hamid Y. , Mamdouh Heba , Ibrahim Gamal , Al Faisal Waleed , Monsef Nahed  , Farghaly Mohammad
Published: July 2020

Background: Diabetes mellitus is a leading cause of morbidity and mortality worldwide, imposing a considerable burden on health systems and societies as it affects both individuals and their families and has a large impact on the economic and social development of a country. Objectives: The purpose of this study was to study the prevalence of diabetes and pre-diabetes among the Dubai population and associations with diabetes risk factors. Methodology: A cross-sectional Diabetes Household Survey was carried out in the Emirates of Dubai during 2017 as a complementary stage of the Dubai Household Survey, 2014, which was a randomly selected, multistage, stratified, cluster survey. The sampling technique was selected to assess the rates of undiagnosed diabetes as well as the rates of pre-diabetes through screening with HbA1c. The size of the 2017 survey sample was estimated at 300 individuals for Emirati and 300 for non-Emirati. An additional 200 individuals were added to address non-response cases. These were added to those who were identified as diabetics in the 2014 Household Health Survey and then weighted to give a representative sample for the Dubai population. Results: The study revealed that the prevalence of diabetes in Dubai among UAE nationals was 19%, and it was 14.7% for expats. Consequently, the overall prevalence of diabetes in Dubai is 15.2%. Undiagnosed diabetes was 10% in UAE nationals and 10.9% in expats. Pre-diabetes in UAE national males was lower than in females, although this pattern was not observed among expats. Younger age, normal weight, and exercise were associated with lower rates of diabetes and pre-diabetes in UAE nationals and expats. Hypertension was associated with higher rates of diabetes regardless of nationality. Conclusions: The study concluded that the prevalence of diabetes among the Dubai population is alarmingly high and that a large proportion of the population are not aware of their diagnosis. A higher prevalence of diabetes is associated with multiple factors, such as age, male gender, hypertension, higher BMI, lack of exercise, and lower level or no education, as well as a family history of diabetes mellitus. Many of these factors can be easily modified, which could lead to a decrease in the burden of the disease.
História, analogia e natureza em Novalis
Authors: Losso Eduardo Guerreiro Brito
Published: July 2020

Ao formular as três etapas do destino histórico do Ocidente em Cristandade ou Europa, Novalis oferece a promessa de uma síntese futura entre a Idade Média e o Iluminismo na figura do erudito alemão romântico. Nele, o entusiasmo científico e filosófico irá ao encontro do arrebatamento místico e poético, em vez de o combater. Ele reconciliará arte e ciência, mundo sensível e espiritual, natureza e história, sagrado e profano. Já no romance Os discípulos de Sais há uma série de correlações vertiginosas entre natureza, espírito, corpo e história que não podem ser feitas por um cientista. Só podem ser geradas pelo poeta, o único que compreende o sentido da natureza. O artigo pretende mostrar o quanto o ideal de reencantamento dos dois livros está ligado ao saber analógico renascentista que, segundo Hartmut Böhme, introduz uma semiologia da natureza baseada em vínculos de semelhança entre as coisas. Se, na Renascença, é o filósofo natural que decifra a assinatura das coisas, em Novalis é o poeta que faz da linguagem a chave do reencantamento e da liberdade. O artigo termina refletindo sobre o conflito entre ilusão e realidade na poesia moderna.
Effects of Sugar‐Sweetened, Artificially Sweetened, and Unsweetened Beverages on Cardiometabolic Risk Factors, Body Composition, and Sweet Taste Preference: A Randomized Controlled Trial
Authors: Ebbeling Cara B. , Feldman Henry A. , Steltz Sarah K. , Quinn Nicolle L. , Robinson Lisa M. , Ludwig David S.
Published: July 2020

Background

A 2018 American Heart Association science advisory indicated that, pending further research, artificially sweetened beverages (ASBs) may be an appropriate initial replacement for sugar‐sweetened beverages (SSBs) during transition to unsweetened beverages (USBs).

Methods and Results

We randomly assigned 203 adults (121 males, 82 females; 91.6% retention), who habitually consumed SSBs, to 3 groups and delivered free SSBs, ASBs, or USBs to their homes for 12 months. Outcomes included serum triglyceride to high‐density lipoprotein cholesterol ratio (primary), body weight, and sweet taste preference (experimental assessment, 0%–18% sucrose solutions). Change in serum triglyceride to high‐density lipoprotein cholesterol ratio was not different between groups. Although overall change in weight also was not different between groups, we found effect modification (
P
=0.006) by central adiposity. Among participants in the highest tertile of baseline trunk fat but not other tertiles, weight gain was greater (
P
=0.002) for the SSB (4.4±1.0 kg, estimate±SE) compared with ASB (0.5±0.9 kg) or USB (−0.2±0.9 kg) group. Both sweetness threshold (–1.0±0.2% m/v;
P
=0.005) and favorite concentration (–2.3±0.4% m/v;
P
<0.0001) decreased in the USB group; neither changed in the SSB group. In the ASB group, sweetness threshold did not change, and favorite concentration decreased (–1.1±0.5% m/v;
P
=0.02). Pairwise comparison between the ASB and USB groups indicated a difference in sweetness threshold (
P
=0.015).

Conclusions

Replacing SSBs with noncaloric beverages for 12 months did not affect serum triglyceride to high‐density lipoprotein cholesterol ratio. Among individuals with central adiposity, replacing SSBs with either ASBs or USBs lowered body weight. However, USBs may have the most favorable effect on sweet taste preference.

Registration

URL:
https://www.clinicaltrials.gov
; unique identifier: NCT01295671.
Dismal Outcomes and High Societal Burden of Mitral Valve Regurgitation in France in the Recent Era: A Nationwide Perspective
Authors: Messika‐Zeitoun David , Candolfi Pascal , Vahanian Alec , Chan Vincent , Burwash Ian G. , Philippon Jean‐François , Toussaint Jean‐Manuel , Verta Patrick , Feldman Ted E. , Iung Bernard , Glineur David , Mesana Thierry , Enriquez‐Sarano Maurice
Published: July 2020

Background

Although US recent data suggest that mitral regurgitation (MR) is severely undertreated and carries a poor outcome, population‐based views on outcome and management are limited. We aimed to define the current treatment standards, clinical outcomes, and costs related to MR at the nationwide level.

Methods and Results

In total, 107 412 patients with MR were admitted in France in 2014 to 2015. Within 1 year, 8% were operated and 92% were conservatively managed and constituted our study population (68% primary MR and 32% secondary MR). The mean age was 77±15 years; most patients presented with comorbidities. In‐hospital and 1‐year mortality rates were 4.1% and 14.3%, respectively. Readmissions were common (63% at least once and 37% readmitted ≥2 times). Rates of 1‐year mortality or all‐cause readmission and 1‐year mortality or heart failure readmission were 67% and 34%, respectively, and increased with age, Charlson index, heart failure at admission, and secondary MR etiology; however, the event rate remained notably high in the primary MR subset (64% and 28%, respectively). The mean costs of hospital admissions and of readmissions were 5345±6432 and 10 080±10 847 euros, respectively.

Conclusions

At the nationwide level, MR was a common reason for admission and affected an elderly population with frequent comorbidities. Less than 10% of patients underwent a valve intervention. All subsets of patients who were conservatively managed incurred high mortality and readmissions rates, and MR represented a major societal burden with an extrapolated annual cost of 350 to 550 million euros (390–615 million US dollars). New strategies to improve the management and outcomes of patients with both primary and secondary MR are critical and warranted.
Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke
Authors: Keene Keith L. , Hyacinth Hyacinth I. , Bis Joshua C. , Kittner Steven J. , Mitchell Braxton D. , Cheng Yu-Ching , Pare Guillaume , Chong Michael , O’Donnell Martin , Meschia James F. , Chen Wei-Min , Sale Michèle M. , Rich Stephen S. , Nalls Mike A. , Zonderman Alan B. , Evans Michele K. , Wilson James G. , Correa Adolfo , Markus Hugh S. , Traylor Matthew , Lewis Cathryn M. , Carty Cara L. , Reiner Alexander , Haessler Jeff , Langefeld Carl D. , Gottesman Rebecca , Mosley Thomas H. , Woo Daniel , Yaffe Kristine , Liu YongMei , Longstreth William T. , Psaty Bruce M. , Kooperberg Charles , Lange Leslie A. , Sacco Ralph , Rundek Tatjana , Lee Jin-Moo , Cruchaga Carlos , Furie Karen L. , Arnett Donna K. , Benavente Oscar R. , Grewal Raji P. , Peddareddygari Leema Reddy , Dichgans Martin , Malik Rainer , Worrall Bradford B. , Fornage Myriam ,   on behalf of the COMPASS, SiGN, and METASTROKE Consortia
Published: July 2020

Background and Purpose:

Stroke is a complex disease with multiple genetic and environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2× to 3× more likely to die from stroke than European Americans.

Methods:

The COMPASS (Consortium of Minority Population Genome-Wide Association Studies of Stroke) has conducted a genome-wide association meta-analysis of stroke in >22 000 individuals of African ancestry (3734 cases, 18 317 controls) from 13 cohorts.

Results:

In meta-analyses, we identified one single nucleotide polymorphism (rs55931441) near the
HNF1A
gene that reached genome-wide significance (
P
=4.62×10
−8
) and an additional 29 variants with suggestive evidence of association (
P
<1×10
−6
), representing 24 unique loci. For validation, a look-up analysis for a 100 kb region flanking the COMPASS single nucleotide polymorphism was performed in SiGN (Stroke Genetics Network) Europeans, SiGN Hispanics, and METASTROKE (Europeans). Using a stringent Bonferroni correction
P
value of 2.08×10
−3
(0.05/24 unique loci), we were able to validate associations at the
HNF1A
locus in both SiGN (
P
=8.18×10
−4
) and METASTROKE (
P
=1.72×10
−3
) European populations. Overall, 16 of 24 loci showed evidence for validation across multiple populations. Previous studies have reported associations between variants in the
HNF1A
gene and lipids, C-reactive protein, and risk of coronary artery disease and stroke. Suggestive associations with variants in the
SFXN4
and
TMEM108
genes represent potential novel ischemic stroke loci.

Conclusions:

These findings represent the most thorough investigation of genetic determinants of stroke in individuals of African descent, to date.
Chemobrionics: From Self-Assembled Material Architectures to the Origin of Life
Authors: Cardoso Silvana S. S. , Cartwright Julyan H. E. , Čejková Jitka , Cronin Leroy , De Wit Anne , Giannerini Simone , Horváth Dezső , Rodrigues Alírio , Russell Michael J. , Sainz-Díaz C. Ignacio , Tóth Ágota
Published: July 2020

Self-organizing precipitation processes, such as chemical gardens forming biomimetic micro- and nanotubular forms, have the potential to show us new fundamental science to explore, quantify, and understand nonequilibrium physicochemical systems, and shed light on the conditions for life's emergence. The physics and chemistry of these phenomena, due to the assembly of material architectures under a flux of ions, and their exploitation in applications, have recently been termed chemobrionics. Advances in understanding in this area require a combination of expertise in physics, chemistry, mathematical modeling, biology, and nanoengineering, as well as in complex systems and nonlinear and materials sciences, giving rise to this new synergistic discipline of chemobrionics.
Home range and habitat use of two sympatric crocodylians (Melanosuchus niger and Caiman yacare) under changing habitat conditions
Authors: De la Quintana Paola , Aparicio James , Pacheco Luis F.
Published: July 2020

We used radio-telemetry to record how Caiman yacare (Cy) and Melanosuchus niger (Mn) responded to the intrusion of the Maniqui river into Cedral Lagoon in the Bolivian Amazon. Nine M. niger and 3 C. yacare were followed between December 2015 and May 2016. Both species showed a gradual reduction in mean monthly range from December (19.96 ha Mn and 1.74 ha Cy) to May 2016 (0.08 ha Mn and 0.24 ha Cy). Habitat use was fairly constant throughout the months for both species, Melanosuchus niger used mainly open swampy forests and Cyperaceae Marshes, while C. yacare used more islands and flooded grasslands. This study shows that both species of caimans responded to changes in depth and vegetation types, as their habitat as a whole was changed by river intrusion.
The Scientific Study of Religion: A Very Brief Reply to Donald Wiebe
Authors: Levene Nancy
Published: July 2020

A response to Donald Wiebe’s call for a scientific study of religion.
Breaking the Spell: Reconsidering Cognitive and Evolutionary Approaches to Atheism
Authors: Szocik Konrad , Messick Kyle J.
Published: July 2020

The scientific study of nonreligion has been described as being ‘under the spell’ of religion because the vast majority of research investigates nonbelief in respect to belief. This has resulted in a number of problematic theories, including the leading cognitive science of religion (CSR) theory that claims that religious belief is innate, and so to be a nonbeliever is to violate cognitive predispositions. This article critically analyzes innateness theories and encourages the development of further theories that incorporate social, adaptive, cultural, evolutionary, and biological factors in addition to cognitive contributors. This article details the roles of adaptive and functional aspects of nonbelief, the influence of credibility enhancing displays (CRED s), and the influence of cultural context on nonbelief as they are not sufficiently explained by CSR theories. It is proposed that future theories study nonreligion in its own right, instead of respective to religion, so that a broader range of unique characteristics can be accounted for without inaccurately and inadequately phrasing theories in terms of naturalness.
The genus Lejeunea Lib. (Lejeuneaceae, Marchantiophyta) in Brazil

Authors: BASTOS CID JOSÉ PASSOS , GRADSTEIN S. ROBBERT
Published: July 2020

Lejeunea is one of the largest genera of liverworts in the Neotropics and probably the largest liverwort genus in Brazil. We present the first treatment of Lejeunea for Brazil, and for any major part of the Neotropics. Fifty-eight species and three varieties are recognized. A key to the Brazilian species of Lejeunea is provided and each species is briefly described with data on geographical distribution, habitat, differentiating characters and affinities, and reference to published illustrations. Illustrations of a few selected species are also provided. Almost half of the species (24) are widely distributed in tropical America and four of them occur also in Africa; one species, L. flava, is pantropical. About 40% of the species (23) have more restricted ranges and are limited to tropical South America. Ten of them (L. atlantica, L. beyrichiana, L. combuensis, L. flagellifera, L. juruana, L. longidentata, L. oligoclada, L. perpapillosa, L. pulchra, L. subplana) are only known from Brazil. Within Brazil 19 species are widespread, the remaining ones have restricted distributions in the country. Twenty-three species are newly reduced to synonymy (see list in text), fourteen new lectotypifications are designated, two species are newly described, L. atlantica sp. nov. and L. pulchra sp. nov., and four new combinations are proposed: L. acanthogona var. cristulata comb. nov., L. acanthogona var. diversicuspis comb. nov., L. acanthogona var. grossiretis comb. nov. and L. beyrichiana comb. nov. Lejeunea cochleata is reported new to Brazil and L. rionegrensis is new to Ecuador.
Five new species of cotylean flatworms (Platyhelminthes: Polycladida: Cotylea) from Oaxaca, southern Mexican Pacific
Authors: RAMOS-SÁNCHEZ MARIELA , BAHIA JULIANA , BASTIDA-ZAVALA J. ROLANDO
Published: July 2020

The flatworms of the suborder Cotylea live in diverse marine substrates such as rocks, seaweed and sand or in association with corals. In the Mexican Pacific, particularly on the coast of Oaxaca, knowledge about cotyleans is scarce, with only one record of the genus Pseudoceros. The aim of this work was to describe the cotylean species present in the area. A total of 48 specimens were collected, fixed, mounted in whole mounts or histological sagittal and frontal histological sections of the reproductive systems. These were examined for taxonomic identification, determining five new species of four genera: Boninia oaxaquensis sp. nov., Pericelis sigmeri sp. nov., Pericelis nazahui sp. nov., Pseudoceros bicuti sp. nov. and Thysanozoon estacahuitensis sp. nov. The present study establishes the first record of the genus Boninia and the family Boniniidae for the Tropical Eastern Pacific. It also confirms the presence of the genus Pseudoceros on the coast of Oaxaca, and break the disjunct distribution of this genus (from Gulf of California to Gulf of Tehuantepec), as well as the genus Pericelis (from Canada to Galapagos Islands) and Thysanozoon (from Chile to Gulf of California).
A new, uniquely patterned spiny eel (Teleostei: Mastacembelidae) from southern Borneo, Kalimantan Tengah, Indonesia
Authors: NG HEOK HEE , TAN HEOK HUI
Published: July 2020

A new species of Macrognathus of the M. aculeatus species group is described from the Kahayan River drainage in southern Borneo, Kalimantan Tengah, Indonesia. Macrognathus kris, new species, is distinguished from all Asian congeners in having the following unique combination of characters: rim of anterior nostril with two fimbriae and two fimbrules; 43–45 rostral tooth plates; 24–25 dorsal spines; 46–55 dorsal-fin rays; 51–59 anal-fin rays; 20–23 principal caudal-fin rays; 76–78 total vertebrae; body depth at anus 11.8–15.9% SL; color pattern consisting of light brown stripe on dorsum and 11–14 irregular pentagonal dark brown blotches on sides of body.
A Hail Growth Trajectory Model for Exploring the Environmental Controls on Hail Size: Model Physics and Idealized Tests
Authors: Kumjian Matthew R. , Lombardo Kelly
Published: July 2020

A detailed microphysical model of hail growth is developed and applied to idealized numerical simulations of deep convective storms. Hailstone embryos of various sizes and densities may be initialized in and around the simulated convective storm updraft, and then are tracked as they are advected and grow through various microphysical processes. Application to an idealized squall line and supercell storm results in a plausibly realistic distribution of maximum hailstone sizes for each. Simulated hail growth trajectories through idealized supercell storms exhibit many consistencies with previous hail trajectory work that used observed storms. Systematic tests of uncertain model parameters and parameterizations are performed, with results highlighting the sensitivity of hail size distributions to these changes. A set of idealized simulations is performed for supercells in environments with varying vertical wind shear to extend and clarify our prior work. The trajectory calculations reveal that, with increased zonal deep-layer shear, broader updrafts lead to increased residence time and thus larger maximum hail sizes. For cases with increased meridional low-level shear, updraft width is also increased, but hailstone sizes are smaller. This is a result of decreased residence time in the updraft, owing to faster northward flow within the updraft that advects hailstones through the growth region more rapidly. The results suggest that environments leading to weakened horizontal flow within supercell updrafts may lead to larger maximum hailstone sizes.
Vertical Structure of the Upper–Indian Ocean Thermal Variability
Authors: Li Yuanlong , Han Weiqing , Wang Fan , Zhang Lei , Duan Jing
Published: July 2020

Multi-time-scale variabilities of the Indian Ocean (IO) temperature over 0–700 m are revisited from the perspective of vertical structure. Analysis of historical data for 1955–2018 identifies two dominant types of vertical structures that account for respectively 70.5% and 21.2% of the total variance on interannual-to-interdecadal time scales with the linear trend and seasonal cycle removed. The leading type manifests as vertically coherent warming/cooling with the maximal amplitude at ~100 m and exhibits evident interdecadal variations. The second type shows a vertical dipole structure between the surface (0–60 m) and subsurface (60–400 m) layers and interannual-to-decadal fluctuations. Ocean model experiments were performed to gain insights into underlying processes. The vertically coherent, basinwide warming/cooling of the IO on an interdecadal time scale is caused by changes of the Indonesian Throughflow (ITF) controlled by Pacific climate and anomalous surface heat fluxes partly originating from external forcing. Enhanced changes in the subtropical southern IO arise from positive air–sea feedback among sea surface temperature, winds, turbulent heat flux, cloud cover, and shortwave radiation. Regarding dipole-type variability, the basinwide surface warming is induced by surface heat flux forcing, and the subsurface cooling occurs only in the eastern IO. The cooling in the southeast IO is generated by the weakened ITF, whereas that in the northeast IO is caused by equatorial easterly winds through upwelling oceanic waves. Both El Niño–Southern Oscillation (ENSO) and IO dipole (IOD) events are favorable for the generation of such vertical dipole anomalies.
A Prospective Randomized Trial of N-butyl-cyanoacrylate + Metacryloxysulfolane Adhesive versus Suture Alone for Grafting in Rhinoplasty: 9 year Follow-up
Authors: Martino Carmine , Salzano Francesco , Martino Diletta , Ralli Massimo , De Vincentiis Marco , Maranzano Massimo , Greco Antonio , Salzano Giovanni , Di Stadio Arianna
Published: July 2020

Objective:

Use of cyanoacrylate glue in facial plastic surgery is still controversial due to the absence of long-term follow up showing the results. Aim of our study is comparing the long-term outcomes of N-butyl-cyanoacrylate + Metacryloxysulfolane versus traditional sutures in rhinoplasty.

Methods:

Prospective comparative study. One hundred forty-two patients affected by ptotic nasal tip were included and randomized in two groups. In group A, the surgeon fixed the graft by using the glue and suture and in group B by using the traditional suture only. The following data were collected and compared by statistical analysis: nasolabial angle before and after surgery, dimensions of the graft, duration time (in minutes) for graft application during the surgery, number of sutures applied to fix the graft, presence of post-surgery negative outcomes.

Results:

All patients statistically improved their nasolabial angle after surgery (ANOVA: P < .0001) without statistically significant differences between the two groups both at short and long follow-up (χ: P = 1 and P = .9 respectively). A statistically significant difference in graft fixation time ( P < .00001) and number of sutures (t: P < .00001) used was observed between the two groups. No statistically significant difference was observed in prevalence of infection after surgery.

Conclusion:

N-butyl-cyanoacrylate + Metacryloxysulfolane could be a valid tool to reduce the necessary number of sutures and to reduce the time required for graft fixation graft fixation with consistent results in long-term follow-up.
Goal Setting Among Experienced and Novice Occupational Therapists in a Rehabilitation Center
Authors: Šuc Lea , Švajger Andreja , Bratun Urša
Published: July 2020

Background.

Collaborative goal setting is an important part of client-centered occupational therapy. However, not all therapists have comparable skills when it comes to setting goals.

Purpose.

The aim of our study was to explore the experiences of novice and expert occupational therapists who use the Canadian Occupational Performance Measure in the process of goal setting.

Method.

This study followed a focused ethnography approach. Four beginners and four experienced occupational therapists were interviewed about their experiences with goal setting. We also observed them during a goal setting session. Data were analyzed using thematic analysis.

Findings.

The four main themes that emerged from the analysis showed both similarities and differences between novice and experienced therapists, especially in the areas of communication, guidance, and flexibility, as well as dilemmas they were facing.

Implications.

Our findings challenge the client-centeredness of the participants and the relevance of work experience when it comes to collaborative goal setting.
A Culturally Modified Application of Objectification Theory to Asian and Asian-American Women
Authors: Ko Stacy Y. , Wei Meifen
Published: July 2020

In the current study we sought to find support for a culturally modified application of objectification theory to Asian and Asian American women. The positive association between socialization experiences (i.e., racial teasing and appearance-focused social pressure) and the outcome variable (i.e., consideration of cosmetic surgery) was hypothesized to be mediated by self-objectification processes (i.e., internalization of beauty standards, body surveillance, and lower body esteem). Results using path analysis showed that culturally dominant (United States) and culturally specific (Asian) internalization of beauty standards, culturally dominant (United States) and culturally specific (Asian) body surveillance, and lower body esteem were significant mediators between socialization experiences and consideration of cosmetic surgery. A multiple-group analysis demonstrated equivalence of the model for Asian international and Asian American female students, showing that both dominant and culturally specific beauty standards may contribute to self-objectification processes for this population.
Recidivism by Conviction Offense Type and Release Status Among Prisoners Released in Iowa
Authors: Moore John , Eikenberry Jacob
Published: July 2020

Recidivism rates vary by conviction offense type and release status. Less is understood regarding associations of conviction offense type and release status on the specific recidivism outcomes of overall recidivism, new recidivism, and technical recidivism. This study examined associations of overall recidivism, new recidivism, and technical recidivism over a 3-year period among individuals released from the Iowa Department of Corrections from 2010 to 2014 ( N = 18,947). Recidivism was operationalized as reincarceration in this study. Drug offenders were the largest group released to supervised parole, and the highest proportion of offenders reincarcerated were drug offenders. Those released without supervision had lower odds of overall recidivism. Findings demonstrate that associations of recidivism outcomes vary based on recidivism operationalization, conviction offense type, and release status.
MicroRNA-29b Promotes Subchondral Bone Loss in TMJ Osteoarthritis
Authors: Sun J.L. , Yan J.F. , Yu S.B. , Zhao J. , Lin Q.Q. , Jiao K.
Published: July 2020

Abnormal subchondral bone remodeling plays important roles during osteoarthritis (OA) pathology. Recent studies show that bone marrow mesenchymal stem cells (BMSCs) in osteoarthritic subchondral bones exhibit a prominent pro-osteoclastic effect that contributes to abnormal subchondral bone remodeling; however, the pathologic mechanism remains unclear. In the present study, we used a mouse model with OA-like change in the temporomandibular joint (TMJ) induced by an experimentally unilateral anterior crossbite (UAC) and found that the level of microRNA-29b ( miR-29b), but not miR-29a or miR-29c, was markedly lower in BMSCs from subchondral bones of UAC mice as compared with that from the sham control mice. With an intra-articular aptamer delivery system, BMSC-specific overexpression of miR-29b by aptamer-agomiR-29b rescued subchondral bone loss and osteoclast hyperfunction in UAC mice, as demonstrated by a significant increase in bone mineral density, bone volume fraction, trabecular thickness, and the gene expression of osteocalcin and Runx2 but decreased trabecular separation, osteoclast number and osteoclast surface/bone surface, and the gene expression of cathepsin K, Trap, Wnt5a, Rankl, and Rank as compared with those in the UAC mice treated by aptamer-NC (all P < 0.05). In addition, BMSC-specific inhibition of miR-29b by aptamer-antagomiR-29b exacerbated those responses in UAC mice. Notably, although it primarily affected miR-29b levels in the subchondral bone (but not in cartilage and synovium), BMSC-specific overexpression of miR-29b in UAC mice largely rescued OA-like cartilage degradation, including decreased chondrocyte density, cartilage thickness, and the percentage areas of proteoglycans and type II collagen, while BMSC-specific inhibition of miR-29b aggravated these characteristics of cartilage degradation in UAC mice. Moreover, we identified Wnt5a, but not Rankl or Sdf-1, as the direct target of miR-29b. The results of the present study indicate that miR-29b is a key regulator of the pro-osteoclastic effects of BMSCs in TMJ-OA subchondral bones and plays important roles in the TMJ-OA progression.
Motivations for Diverted Buprenorphine Use in a Multisite Qualitative Study
Authors: Kavanaugh Philip R. , McLean Katherine
Published: July 2020

Drawing on a multisite sample of 40 persons who sell, share, or use diverted buprenorphine to manage opioid use disorder, in this study we describe why individuals seek to obtain buprenorphine outside of formal treatment contexts, and between-site variation regarding their motives and means. Findings indicate that both the provision and purchase of diverted buprenorphine support user-defined risk minimization strategies to avoid withdrawal, reduce heroin use, and satiate opioid cravings in periods of lowered tolerance. We also found that a subset of the sample used buprenorphine recreationally, and that it functioned to extend or augment illicit drug use careers. Implications of the findings are discussed in light of federal and state drug control and treatment policies.
Jasenovac
Authors: Byard Roger W
Published: July 2020

Jasenovac was a camp run by the Ustaše Supervisory Service (UNS) of the Independent State of Croatia during World War II. It was located approximately 100 km south-east of Zagreb on the banks of the Sava River. Although the purpose of, and number of deaths in, the camp have been debated, it appears that a significant number of Serbs, Roma and Jews died and/or were executed at this site between 1941 and 1945. The site demonstrates that not all detention camps at this time were controlled by the German government and that cultural/religious groups other than the Jews were detainees. Balkan mass graves may therefore derive from different conflicts at different times, and so establishing accurate conclusions from excavations often requires a verifiable and plausible context and an understanding of burial processes.
Prefigurative Politics and Social Movement Strategy: The Roles of Prefiguration in the Reproduction, Mobilisation and Coordination of Movements
Authors: Yates Luke
Published: July 2020

Recent work historicises and theoretically refines the concept of prefigurative politics. Yet disagreements over the question of whether or how it is politically effective remain. What roles does prefiguration play in strategies of transformation, and what implications does it have for understandings of strategy? The article begins to answer this question by tracking the concept’s use, from discussions of left strategy in the 1960s, a qualifier of new social movements in the 1980s–1990s, its application to protest events in the 2000s, to its contemporary proliferation of meanings. This contextualises reflections on the changing arguments about the roles of prefiguration in social movement strategy. Based on literature about strategy, three essential categories of applied movement strategy are identified: reproduction, mobilisation and coordination. Prefigurative dynamics are part of all three, showing that the reproduction of movements is strategically significant, while the coordination of movements can take various ‘prefigurative’ forms.
Employability With Mental Illness: The Perspectives of Employers and Mental Health Workers
Authors: Lettieri Andrea , Soto-Pérez Felipe , Franco-Martín Manuel A. , de Borja Jordán de Urríes Francisco , Shiells Kate R. , Díez Emiliano
Published: July 2020

Having prior contact with people with mental illness in the workplace can lead to an improvement in employers’ attitudes toward this group. However, there is currently a lack of instruments to measure attitudes toward the employability of people with mental illness. The overall aim of this study was to develop a Spanish scale of attitudes toward the employability of people with mental illness (CEPEM) and obtain preliminary data regarding its psychometric properties. Ninety-four items from three content domains were selected (attitudes, employability, and impact) and revised in an inter-rater agreement procedure in order to produce an initial scale. The scale was tested by employers and workers from the field of mental health. A reduced set of items was selected according to variability and homogeneity indexes. Additional analyses were conducted to explore the validity of the scale. Internal consistency was estimated for the full 33-item scale. Scale scores partially captured attitudinal differences between employers and workers. Finally, linear multiple regression analysis showed that the scale score, in combination with educational level, can help to predict employers’ intentions to hire people with mental illness. Limitations and future research directions are also addressed.
Critical Race Structuralism: The Role of Science Education in Teaching Social Justice Issues in Urban Education and Pre-Service Teacher Education Programs
Authors: Wiggan Greg , Pass Michelle B. , Gadd Sonja R.
Published: July 2020

Using critical race structuralism (CRS), a new contribution, as well as primary and secondary data, this article explores the role of science in teaching social justice issues in urban education. In the United States, a teaching workforce, which is predominately White, middle class, and female, intersects with an increasingly diverse student population, creating a need for culturally responsive teaching practices, particularly in science, technology, engineering, and math (STEM), and science, technology, engineering, arts, and math (STEAM) classes. An investigation of existing literature reveals the need for greater emphasis on environmental racism and social justice as they pertain to students living in low-income and urban communities. Our findings reveal that CRS can be utilized in a collective effort to transform teacher education programs and teacher pedagogy, to effectively address environmental racism and other social justice issues in urban schools and communities.