bluuebunny/crossref_metadata_2025 huggingface dataset:
以機器學習法建立糖尿病營養衛教門診病人血糖變化之預測模型與系統以輔助臨床決策
Authors: 劉美媛 劉美媛 , Mei-Yuan Liu 劉忠峰 , Chung-Feng Liu 馬于珊 , Yu-Shan Ma 陳佳群
Published: July 2022

目的：以機器學習技術建立有效預測糖尿病個案之長期血糖變化模型，並實作成系統，提供予病人營養介入輔助決策之參考。

材料與方法：數據來源為奇美醫療體系三院區門診營養衛教系統2007至2019年加入糖尿病試辦計畫之成年病人就診營養衛教紀錄，依文獻與專業經驗選擇20個特徵變數，以多種機器學習演算法建立「預測一年後病人糖化血色素是否改善達7%以上」之模型。最後挑選最佳模型（Area Under the Curve[AUC]最高者）實作成預測系統以供臨床使用。

結果：各機器學習法建立之模型精確度在0.735~0.749間，其中支持向量機法之敏感性達0.757、特異性0.739、AUC值0.828，為最佳模型。我們將預測系統提供給3位營養師試用，均獲得正面的肯定，認為此系統對糖尿病營養諮詢衛教非常有幫助。

結論：以機器學習建立之預測模型具有優異的品質，為糖尿病營養諮詢衛教提供非常有前景的方法，可作為臨床疾病照護及飲食衛教介入之有效參考，使病人維持良好之長期血糖控制，減少糖尿病引發合併症發生率，有助於提升醫療品質與促進醫病共享決策。

 

Purpose: The prevalence of diabetes mellitus (DM) continues to increase worldwide. We built a machine learning model and developed a prediction system that is based on an optimal model to effectively predict blood sugar changes in patients with diabetes. Our findings contribute to the implementation of long-term patient nutrition interventions.

Method: Data of outpatients with type 2 DM who were 20 years or older and underwent nutrition education under a diabetes pay-for-performance program were obtained from the Nutrition and Health System Database of the outpatient clinic of the Chi Mei Hospital network; the data spanned the years from 2007 to 2019. On the basis of literature findings and professional experience, 20 characteristic variables and multiple machine learning algorithms were applied to build a model to predict whether the glycosylated hemoglobin (HbA1c) of the outpatients improved by more than 7% after 1 year. The optimal model (model with the highest area under the curve [AUC]) was selected and used to develop a prediction system for use in clinical settings.

Results: The accuracy levels of the developed models ranged from 0.735 to 0.749; the supportvector- machine model with a sensitivity of 0.757, a specificity of 0.739, and an AUC of 0.828 was the optimal prediction model. The prediction system was tested by three dietitians, who affirmed its usefulness for diabetes meal planning and patient health education.

Conclusion: The prediction model based on machine learning algorithms performed excellently, and it is a promising tool for diabetes meal planning and patient health education. It is also an effective supporting tool for clinical disease care and dietary health education interventions. We believe that the model can help patients maintain favorable long-term blood sugar control, reduce their incidence of diabetes-related complications, improve the quality of medical care and promote shared decisionmaking.

 
以專案管理提升住院期間非計畫重返手術室指標正確性
Authors: 張簡志炫 張簡志炫 , Chih-Hsuan Chang-Chien 方前量 , Chien-Liang Fang 賴雅燕 , Ya-Yan Lai 周詠欽 , Yeong-Chin Jou 沈正煌
Published: July 2022

非計畫重返手術室是台灣臨床成效指標手術照護中的重要指標之一，常與前次手術的併發症有高度的相關性，又不易釐清計畫與非計畫、相關與不相關，使這支指標的正確性備受爭議。團隊藉由專案管理手法達成1.指標統計一致與正確、2.分析非計畫相關及非相關重返手術原因、3.提升手術安全與照護品質。與2014年同期相比，2015年嘉基非計畫性相關重返之發生率（P值）由1.2%降低至0.67%、2017年0.61%、2018年0.61%。藉由外科系品質會議逐案分析討論，整合醫療、護理、行政資訊共識，導正資料的正確性，由專案管理的過程重新檢視指標定義、指標收案流程及數值來源，可建立指標內部稽核制度及自我驗證指標資料正確性之機制，加強人員對醫療品質的重視度及參與度，讓病人安全與品質改善日常化。

 

Unplanned reoperation is a key indicator in surgical care category of Taiwan Clinical Performance Indicator and is highly correlated with complications associated with the previous operation. Distinguishing between planned and unplanned and related and unrelated surgery is difficult, and the correctness of indicators is frequently disputed. The research team used project management techniques (1) to obtain consistent and correct indicator statistics; (2) to analyze the reasons for unplanned reoperation; and (3) to improve surgical safety and care quality. Compared with 2014, in 2015, the incidence of unplanned reoperation (P value) in Ditmanson Medical Foundation Chia- Yi Christian Hospital decreased from 1.2% to 0.67% and further decreased to 0.61% in 2017 and 2018. Through the case-by-case analysis of cases presented at the surgical quality conference, the consensus on medical, nursing, and computer statistics was integrated to enhance data accuracy. Through reexamination of the definition of critical indicators, the process of indicator acceptance, and the source of values using project management techniques, an internal audit system for indicators and a mechanism for the self-verification of the correctness of indicator data was established to strengthen the attention and participation of medical personnel in medical quality, thereby improving medical quality and patient safety.

 
臺灣的高齡友善環境因應身心障礙者權利公約(CRPD)如何實踐通用設計之論述—以鄰里公園、長照機構、醫院為例
Authors: 黃耀榮 黃耀榮
Published: July 2022

臺灣為符合國際人權潮流，正式推動身心障礙者權利公約(Convention on the Rights of Persons with Disabilities, CRPD)。國際審查委員認為臺灣普遍缺乏無障礙環境，以及缺乏通用設計的法律定義及應用。通用設計所追求的理想在於將適用性極大化至每個人都可以使用同一設施設備，但是無障礙環境係追求每個人都有設施設備可以使用；臺灣要能先普及化無障礙環境，才有基礎實踐通用設計理念。

臺灣未來推動高齡友善環境，除了高齡者活動與照顧相關的社區生活設施、照顧機構之外，高齡者就醫、復能的醫療場所也應列為重點場所，且在建構無障礙環境的過程中漸進式同時實踐通用設計理念，將是需要思考的關鍵議題。

 

To support the global trend of accentuating human rights protection, Taiwan has officially begun to promote the Convention on the Rights of Persons with Disabilities (CRPD). International reviewers conclude that Taiwan lacks accessible environments as well as legal definitions and applications of universal design. Universal design seeks to maximize applicability by creating facilities and equipment usable by everyone. Similarly, accessible environments aim to ensure the access of facilities and equipment to all users. Taiwan must first achieve the prevalence of accessible environments before it can apply the principle of universal design.

For its subsequent promotion of age-friendly environments, Taiwan should focus on healthcare venues providing medical treatment and rehabilitation to older adults, in addition to community amenities and care institutions for this age group. A key topic meriting further exploration is the progressive implementation of universal design elements during the construction of barrier-free environments in Taiwan.

 
佛教慈濟醫療財團法人花蓮慈濟醫院疾病照護品質認證經驗分享
Authors: 張家銘 張家銘 , Chia-Ming Chang 田淑惠
Published: July 2022

臺灣近年來關節退化疾病族群比例持續上升，而人工關節置換是關節退化末期的首選治療。良好的人工關節置換，除了骨科手術本身外，應該包含術前評估、衛教及術後護理、止痛、復健等，而這些都需仰賴其他跨領域團隊的共同合作，然則要整合各專業領域團隊實非易事，所幸財團法人醫院評鑑暨醫療品質策進會所制訂之「關節置換疾病品質認證」給予我們明確指引及標準，同時亦督促整合各領域醫療團隊，發揮跨團隊效能，讓整體醫療品質有質的飛躍。

 

Recent years have seen a continual rise in the prevalence of degenerative joint diseases in Taiwan, where arthroplasty has become the most common method for treating end-stage joint degeneration. In addition to orthopedic surgery, satisfactory arthroplasty requires satisfactory preoperative assessment, health education, postoperative care, pain relief, and rehabilitation, all of which rely on interdisciplinary collaboration among healthcare professionals. Assembling a team of professionals across different disciplines is a challenging task. Therefore, Joint Commission of Taiwan has developed the joint replacement care certification to provide a set of clear guidelines and standards for arthroplasty. Integration of interdisciplinary teams should be prioritized to ensure efficient collaboration and substantially improve the overall healthcare quality.

 
與新冠肺炎共存下的兒童及青少年疫苗觀點
Authors: 許玉龍 許玉龍
Published: July 2022

相對成人而言，兒童及青少年感染新冠肺炎(COVID-19)的症狀雖然比較輕微，感染後仍有可能出現重症如兒童多系統發炎症候群，或產生長期的併發症如急性感染後徵候群。兒童及青少年接種COVID-19疫苗可預防其住院或得到重症及併發症、減少COVID-19病毒變異與傳播及儘快回復正常生活。多數研究及持續的安全監測證實核糖核酸疫苗對兒童及青少年具安全性，接種後產生心肌炎／心包膜炎的嚴重副作用較少見，且大多數病人經醫療照護後皆痊癒。先前因有對抗COVID-19的高強度防疫措施及疫苗，大大減少了其他傳染病的案例，然而這也導致免疫負債的產生，可能會導致被壓抑的傳染病反撲。在與COVID-19共存的時代，防疫措施將大幅度的解封，若進入秋冬季節，流感病毒勢必開始活躍，有可能與新冠病毒造成雙重流行。因此，除鼓勵兒童及青少年維持良好衛生習慣，接種常規疫苗（包含COVID-19疫苗及流感疫苗）是減少免疫負債及雙重流行衝擊最佳的方法。

 

Although the severity of COVID-19 infection is lower in children and adolescents than in adults, children and adolescents are encouraged to receive vaccination to prevent hospitalization and complications, such as multisystemic inflammatory syndrome and post-COVID conditions, reduce the spread of COVID-19, prevent the emergence of other variants, and restore a normal life. COVID-19 mRNA vaccines are suggested to be safe for children and teenagers. Severe events, such as myocarditis and pericarditis, after pediatric COVID-19 mRNA vaccination are rare. Most patients fully recover after management. Strict public health nonpharmaceutical interventions and vaccination program disturbances may cause an immunity debt in children. Therefore, vaccine-preventable diseases may reemerge after the lifting of COVID-19 mitigation measures. Twindemic may occur in the next influenza season due to the coexistence of influenza and SARS-CoV-2 viruses. In addition to maintaining good hygiene, emphasizing and encouraging pediatric routine immunization, including COVID-19 and influenza vaccination, are the most favorable methods for overcoming immunity debt and preventing twindemic.

 
醫療照護場域之性別與健康
Authors: 鍾成鴻 鍾成鴻
Published: July 2022

臺灣醫療場域因應2005年推動性別主流化之國家政策，亦適時調整相關各項醫療規定及推行健康促進政策，如「醫師執業登記及繼續教育辦法」第8條中，規定醫師每6年換照時應完成繼續教育，課程內容包括醫學倫理、醫療法規等，還包括「性別議題」之課程。學習性別教育對於醫療照護場域的益處究竟為何？

本文將探討性別主流化政策進入醫療領域後對病人健康照護之幫助、過去醫療場域可能造成之性別偏見與治療影響，以及看見醫療環境下之性別差異。醫事人員繼續教育課程納入性別議題，可提升性別敏感度、性別意識，以達到全人醫療、全人照護的最終目標。

 

In response to Taiwan’s promotion of the national gender mainstreaming policies in 2005, relevant regulations in healthcare venues have been adjusted, and health promotion policies have been implemented promptly. According to Article 8 of the Guidelines for the Licensing and Continuing Education of Physicians, physicians are required to complete their continuing education when they renew their licenses every 6 years. This education should cover subjects on medical ethics, medical regulations, and gender issues. Debates have emerged regarding the benefits of gender education to healthcare practice.

This study explored how the implementation of gender mainstreaming policies in healthcare venues benefits patient care; examined the effect of gender discrimination on healthcare treatment before policy implementation; depicted gender differences in the healthcare environment. Incorporating gender issues into continuing education received by healthcare professionals raises their gender sensitivity and awareness, helping them provide holistic health care.

 
“The Refining of Your Faith”?: Metallurgic Testing Imagery in James
Authors: Eng Daniel K.
Published: July 2022

This article proposes that (1) the author of James uses metallurgic imagery in the opening exhortation and (2) a thematic thread runs through Jas 2:1–3:12 in light of the two inextricable qualities of precious metals: genuineness and purity. This case is supported by an examination of the key terms δοκίμιον and δόκιμος in Jas 1, the testing/refining process of precious metals in antiquity, and usage of metallurgic imagery in Jewish and early Christian literature. After making a case for this concept in the prologue and Jas 2:1–3:12, I suggest that the theme also tacitly recurs in other parts of the epistle.
Clothing Norm and Attires of the Ottoman İlmiye Class
Authors: Çelik Murat
Published: July 2022

Those who founded and built the Ottoman mentality is the Ottoman ulema and the ilmiye class, which is its institutional structure. Although ulema, which constitutes the Ottoman ilmiye class within the military class, is divided into different sub-classes, the center they are affiliated with is the Ottoman medrese. In this regard. the Ottoman medreses are the center of the Ottoman ilmiye class and its intellectual mentality; therefore, it has its own tradition. customs, and clothing form. And attires make the Ottoman ilmiye visible within the state with all its elements and reiterate its status. The clothing regulations and differences of the Ottoman ilmiye class manifest themselves strongly from studentship, which is the lowest level, to the office of the sheikh al-Islam, the highest post. Differences and status regulations are made distinct through the design and colors of attires as well. Thus, they are rendered easily distinguishable in society. With this study, covering the attires belonging to the Ottoman ilmiye class, it is aimed to provide a contribution to three fields. Firstly, it is aimed to unfold the clothing norms of the Ottoman ilmiye class, and hence to establish a theoretical base. Surely, the clothing norm of the Ottoman ilmiye class has a philosophical background and reason. The design of this theoretical plan and reason is discussed in this study. Another target is to classify attires belonging to the Ottoman ilmiye class, to serve as a source for future studies. With this classification effort, the ilmiye attires will be sorted out and thus, the attires will be inter-related. The third and last aim is to pave the way for the establishment of the Ottoman ilmiye class attires as a sub-discipline in Ottoman higher education studies. Because a sub-discipline that will serve as a source for comparative studies can be established as such,
Urinary retention by mirtazapine: A case report
Authors: Gajananrao Raje Madhav
Published: July 2022

Introduction: Mirtazapine is considered to be safest and versatile antidepressant. However, sedation is known to be dose dependent side effect. 7.5 mg/day mirtazapine induces more sedation than 15 mg/day mirtazapine. There is no other side effect of mirtazapine which is reported to be dose dependent.
Case Report: Here is a case, where dose dependent urinary retention is detected. A 38-year-old married female reported with array of recurring symptoms like dysphoria, insomnia, loss of appetite, burning all over, uneasiness, increased frequency of micturation and stool, irritability, frustration, weeping often. She was symptomatic since last five to six years, despite regular psychiatric treatment. Her earlier psychiatrist had expressed inability to treat recurrence and intensity of her symptoms. She was kept on mirtazapine 7.5 mg per day to begin with. She responded favorably. To gain more relief dose of mirtazapine was increased to 15 mg/day. Within one to two days she complained of inability to pass urine. Her complaint was specific that she was not able to empty her bladder completely. After completing the act of micturation she used to experience much discomfort in pelvic region. Further investigations revealed significant urinary retention. Lowering of dose brought her relief immediately.
Conclusion: Mirtazapine with dose of 7.5 mg per day effectively could treat recurring symptoms of a female patient. But increase in dose up to 15 mg/day caused significant side effect of urinary retention against the conventional belief of rise in dose of mirtazapine would increase the relief.
COMPARATIVE ANALYSIS OF SURGICAL TREATMENT OF CHILDREN WITH CONGENITAL KIDNEY HYDRONEPHROSIS
Authors: КУСАИНОВ А.З. , ДУЙСЕБАЕВ М.Т. , РАЕВ А.А.
Published: July 2022

В исследование были включены 125 пациента, получавших лечение в урологическом отделении Центра детской неотложной медицинской помощи» г.Алматы за период с 2017 по 2021 гг. Пациенты с врожденным гидронефрозом ІІІ степени были разделены на 2 группы соответственно выполнению видам оперативных вмешательств: 1 группа - открытая люмботомия, 2 группа- пациенты, которым выполнялась лапароскопическая пиелопластика. В данной статье проведено сравнение техники обеих методов оперативного лечения. Произведена оценка таких показателей как: продолжительность оперативного пособия, продолжительность пребывания ребёнка в реанимационном отделении, продолжительность стационарного лечения больного.

The study included 125 patients who received treatment in the urological department of the Center for Children's Emergency Medical Care, Almaty for the period from 2017 to 2021. Patients with grade III congenital hydronephrosis were divided into 2 groups according to the types of surgical interventions: group 1 - open lumbotomy, group 2 - patients who underwent laparoscopic pyeloplasty. This article compares the technique of both methods of surgical treatment. An assessment was made of such indicators as: the duration of the surgical benefit, the duration of the child's stay in the intensive care unit, the duration of the patient's inpatient treatment.
COMPARATIVE CHARACTERISTICS OF THE USE OF BASIC HYPOTENSIVE MONOTHERAPY IN PATIENTS WITH RENAL PATHOLOGY
Authors: НАБИЕВ А.Н. , КАРТАЕВА Т.К. , ДУРМАНОВА А.К. , КУАНШАЛИЕВА Ж.Е. , ДЖУНУСОВА М.Б. , ИГЛИКОВ А.А. , НУРГАЛИЕВА Д.Т. , МАМРАЕВА А.О. , КУЗДЕНБАЕВА Р.С. , САЛЫКБАЕВА Ж.К. , ТАЖИГУЛОВА Ж.М.
Published: July 2022

Артериальная гипертензия (АГ) является важной медико-социальной проблемой как во всем мире, так и в Казахстане. Важным моментом в лечении АГ является проведение своевременной профилактики поражения почек. Целью данного исследования подбор наиболее оптимального гипотензивного нефропротективного препарата у пациентов с гипертонией в сочетании с нефрологической патологией. Материал и методы Работа основана на анализе данных по АД, лабораторных результатов исследований 43 пациентов. Результаты Основными критериями оценки эффективности проводимого лечения являлись: уровень артериального давления, значение креатинина, наличие протеинурии, уровень скорости клубочковой фильтрации. Эти показатели оценивались через месяц, 3 месяца и 6 месяцев приема препарата. Выводы Наиболее эффективными препаратами явились Лозартан (БРА) и периндоприл (ингибитор АПФ), учитывая их воздействие на уровень СКФ и протеинурию. Таким образом нефропротективный эффект данных препаратов был более выражен в сравнении с Амлодипином

Arterial hypertension (ah) is a serious medical and social problem both around the world and in Kazakhstan. An important point in the treatment of AG is timely prevention of kidney damage. The purpose of this study is to select the most optimal hypotensive nephroprotective drug in patients with hypertension with nephrological pathology. Material and methods The work is based on the analysis of data on ICD, the results of laboratory studies of 43 patients. Results The main criteria for evaluating the effectiveness of treatment are: the level of blood pressure, the value of creatinine, the presence of proteinuria, the level of glomerular filtration rate. These indicators were evaluated one month, 3 months and 6 months after taking the drug. Conclusions The most effective drugs were losartan (bra) and perindopril (ACE inhibitor), taking into account their effect on the level of SCF and proteinuria. Thus, the nephroprotective effect of these drugs was more pronounced compared to Amlodipine
MEDICAL AND SOCIAL CHARACTERISTICS OF PUERPERAL WOMEN WITH FETAL MACROSOMIA
Authors: Велиева А.Т. , Омарова Г.К.
Published: July 2022

В статье представлены результаты анализа историй родов родильниц с макросомией для выяснения их медико-социальных особенностей, так как на формирование крупного плода и стрессового недержания мочи у женщин репродуктивного возраста после естественных родов влияют многочисленные факторы, в том числе наследственность, персональные данные, уровень образования, паритет, соматические заболевания и другие. Выявлено, что крупный плод чаще встречается у домохозяек со средне-специальным и незаконченным высшим образованием, повторнородящих женщин с избыточной массой тела, макросомией в предыдущих родах.

This article contains the results of labor and delivery record analysis of the puerperal women with fetal macrosomia in order to determine their medical and social special characteristics, because the macrosomic fetus formation and stress urinary incontinence in women of reproductive age after the vaginal delivery are affected by many factors, including the family history, personal data, educational level, parity, somatic diseases, etc. It was revealed that a fetal macrosomia is more frequent for housewives with secondary specialized education and incomplete higher education, obese multiparas and women with previous fetal macrosomia.
POST-COVID-19 SYNDROME AND DIABETES MELLITUS: A REVIEW
Authors: АБЫЛАЙҰЛЫ Ж. , БОЛЬШАКОВА С.В. , АЛТЫНБЕКОВА С.А.
Published: July 2022

Коронавирусная инфекция представляет собой серьезную пандемию, приводящую к значительной смертности и заболеваемости во всем мире. У большинства пациентов с сопутствующими заболеваниями тяжесть состояния оценивалась от средней до критической, особенно сахарный диабет считается фактором риска неблагоприятного прогноза при COVID-19. Более того, у многих пациентов, выздоравливающих от COVID-19, развиваются стойкие или новые симптомы/ заболевания, которые длятся недели или месяцы. На сегодняшний день долгосрочные последствия COVID-19 для здоровья человека остаются в значительной степени неясными. Последние данные показывают, что 80% пациентов с COVID-19 имеют длительные симптомы, а наиболее частыми жалобами были утомляемость, головная боль, нарушение внимания, выпадение волос и одышка. В данной статье рассматривается влияние сахарного диабета на течение COVID-19, патогенез, клинические проявления пост-COVID-синдрома, а также краткое изложение влияния SARSCoV-2 на развитие впервые диагностированного диабета.

Coronavirus infection is a serious pandemic resulting in significant mortality and morbidity worldwide. In most patients with comorbidities, the severity of the condition was assessed from moderate to critical, especially diabetes mellitus is considered a risk factor for poor prognosis in COVID-19. Moreover, many patients who recover from COVID-19 develop persistent or new symptoms/diseases that last for weeks or months. To date, the long-term effects of COVID-19 on human health remain largely unclear. The latest data show that 80% of patients with COVID-19 have long-term symptoms and the most common complaints were fatigue, headache, impaired attention, hair loss and shortness of breath. This article reviews the impact of diabetes mellitus on the course of COVID-19, pathogenesis, clinical manifestations of post-COVID syndrome, and of the impact of SARS-CoV-2 on the development of newly diagnosed diabetes.
PROSPECTS FOR THE USE OF THE MEDICINAL PLANT MATERIAL - CATNIP HUNGARIAN (NEPETA NUDA L.)
Authors: ЕРДЕНБАЙ А.Н. , УСТЕНОВА Г.О.
Published: July 2022

Одним из приоритетных направлений поиска новых растительных источников биологически активных веществ является изучение малоизученных видов флоры Казахстана. Казахстан характеризуется богатейшим ареалом полезных растений, в первую очередь дикорастущих видов, обладающих лекарственными свойствами. Цель: определение основных направлений исследования лекарственного растительного сырья Котовника венгерского в фармацевтической технологии. Методы исследования: при подготовке данной исследовательской работы использовались систематические, описательные и ретроспективные методы. Результаты. Для дальнейшего исследования было выбрано один из таких перспективных и недостаточно изученных растений - Котовник венгерский (Nepeta nuda Sin. Nepeta pannonica L.), который растет в предгорьях Заилийского Алатау, составляет достаточную сырьевую базу. В надземной части растений рода Nepeta nuda обнаружены различные группы биологически активных соединений: эфирное масло, дитерпеноиды, тритерпеноиды, стероиды, алкалоиды, танины, флавоноиды. Богатый химический состав обуславливает широкий спектр фармакологических активностей Nepeta nuda.

One of the priority directions of search for new plant sources of biologically active substances is the study of poorly studied species of flora of Kazakhstan. Kazakhstan is characterized by the richest a real of useful plants, primarily wild-growing species with medicinal properties. The aim of our research is to identify the main areas of research on the medicinal plant material of Catnip hungarian in pharmaceutical technology. Research methods: systematic, descriptive and retrospective methods were used in preparing this research paper. Results. One such promising and insufficiently studied plant was chosen for further research - Catnip hungarian (Nepeta nuda Sin. Nepeta pannonica L.), which grows in the foothills of the Zailiisky Alatau, constitutes a sufficient raw material base. Various groups of biologically active compounds have been found in the above-ground parts of Nepeta nuda: essential oil, diterpenoids, triterpenoids, steroids, alkaloids, tannins, flavonoids. The rich chemical composition determines a wide range of pharmacological activi-ties of Nepeta nuda.
ASSESSMENT THE QUALITY OF LIFE IN PATIENTS WITH CARDIOVASCULAR DISEASES USING THE SF-36
Authors: Саруаров Е.Г. , Нускабаева Г.О. , Идрисов К.С. , Жунисова М.Б.
Published: July 2022

На сегодняшни день, многие исследования показывают, что риск возникновения сердечно-сосудистых заболеваний и проявления результатов лечения можно определить с помощью простых анкет, определяющих уровень качества жизни. Потому что, здоровье и качество жизни тесно связаны между собой.

Nowadays, many studies show that the risk of cardiovascular disease and the manifestation of treatment results can be determined using the simple questionnaires that determine the level of quality of life. Because health and quality of life are closely related with each other.
THE RESISTANCE OF HELICOBACTER PY-LORI TO ANTIBACTERIAL DRUGS(LITERATURE REVIEW)
Authors: МЫРЗАБЕК Б.Т. , РАХИМОВ К.Д. , КАЛИЕВА Ш.С. , НЕРСЕСОВ А.В. , ЛАВРИНЕНКО А.В.
Published: July 2022

Проблема диагностики и лечения инфекции Helicobacter pylori остается актуальной. Около 50% взрослых по всему миру инфицированы H. pylori. Хронический гастрит, ассоциированный с инфекцией Н. pylori, зачастую является предраковым состоянием и приводит к развитию рака желудка. Киотский глобальный консенсус впервые классифицировал гастрит, ассоциированный H. pylori как инфекционное заболевание, независимо от симптомов и осложнений, что было подтверждено Маастрихтским соглашением V. Устойчивость к противомикробным препаратам различается по географическому расположению стран. Среди стран Юго - Восточной Азии высокая устойчивость к кларитромицину и метронидазолу обнаружена в Китае. Низкая устойчивость к кларитромицину и относительно невысокая устойчивость к метронидазолу обнаружены в России. В некоторых странах, таких как Италия, Португалия, Индия сообщается о высокой устойчивости как к кларитромицину, метронидазолу, также и левофлоксацину. Отсутствие крупных исследований в Казахстане не позволяет представить полную картину сложившейся ситуации в Казахстане. Имеются лишь единичные исследования в популяции крупных городов Казахстана. Значительное повышение устойчивости к кларитромицину и метронидазолу было отмечено за последний год, что позволяет предположить, что приобретение устойчивости связано с высоким уровнем бесконтрольного потребления этих антибиотиков.

The problem of diagnosis and treatment of Helicobacter pylori infection remains relevant. About 50% of adults worldwide are infected with H. pylori. Chronic gastritis associated with H. pylori infection is often a precancerous condition and leads to the development of stomach cancer. The Kyoto Global Consensus was the first to classify H. pylori-associated gastritis as an infectious disease, regardless of symptoms and complications, as confirmed by the Maastricht Agreement V. Antimicrobial resistance varies according to the geographical location of countries. Among Southeast Asian countries, high resistance to clarithromycin and metronidazole is found in China. Low resistance to clarithromycin and relatively low resistance to metronidazole were found in Russia. In some countries, such as Italy, Portugal, and India, high resistance to both clarithromycin, metronidazole, and levofloxacin has been reported. The lack of large-scale research in Kazakhstan does not allow us to present a complete picture of the current situation in Kazakhstan. There are only isolated studies in the population of large cities of Kazakhstan. A significant increase in resistance to clarithromycin and metronidazole has been observed over the past year, suggesting that the acquisition of resistance is associated with a high level of uncontrolled consumption of these antibiotics.
Menadžerske kompetencije instruktora u online obrazovanju odraslih
Authors: Ljujić Bojan
Published: July 2022

Application of modern information and communication technologies (ICT) in education and emergence of new education forms including online education, lead to certain changes relating to teacher's competencies. Special significance is ascribed to managerial skills of instructors in online education, They do not represent something new, but in the context of modfern forms of education they are perceived differently then in traditional education, due to the fact that they are based differently - on technology. This paper primarly seeks to perceive the essence of managerial competencies of online educators, through their positioning and comparison with other important competencies in this type of education as well as consideration in the context of traditional education.
Analysis of available relevant literature led to interesting findings which suggest that managerial competence of online trainers is recognised as very important and that it has a slight priority among other competencies in online education. Some competencies in the set of managerial competencies in online education are not considered to be more important then others, but they are noticeable different then the homogenous ones which are significiant in the context of traditional education. It is also noticeable that managerial competencies are treated differently and in a more specific way in educational litertaure, in relation to scientific sources which originate in other fileds (economy, management etc.)
Saúde mental de estudantes de odontologia: sob a ótica discente
Authors: Bizerril Davi Oliveira , De Senna Juliana Sabóia , Damasceno Laryssa Maria Gomes , De Lima Marília Alves Melquiades , Bezerra Mariana Vieira de Melo
Published: July 2022

O objetivo foi analisar a saúde mental do estudante de graduação em Odontologia de uma universidade privada de Fortaleza, sob a ótica desses estudantes. Trata-se um estudo quantitativo, observacional, descritivo e transversal. Foi aplicado um questionário sobre saúde mental aos estudantes de Odontologia da Universidade de Fortaleza, no ano de 2019, contendo as variáveis: informações pessoais; perfil estudantil e atividades desenvolvidas; identidade pessoal, social e condição física e mental. O projeto foi aprovado pelo Comitê de Ética em Pesquisa da Universidade de Fortaleza, com o parecer nº 3.152.573. Participaram 313 estudantes; 99,7% afirmaram ter satisfação quanto: a autoestima e realização pessoal; ao relacionamento interpessoal com colegas; ao relacionamento interpessoal com professores. Com relação aos transtornos mentais comuns autorreferidos pelos participantes, 63,2% relataram ter algum tipo de transtorno mental. É preocupante a condição de saúde mental dos estudantes, pois na percepção destes, uma parcela significativa possui  algum tipo de transtorno mental.
clinical study of Fournier’s gangrene tertiary care center government medical college, Nizamabad
Authors: Sirasu Madhukar , Ramchandraiah C. , Muralidhar C.
Published: July 2022

Background: Fournier's gangrene (FG) is fast-spreading necrotizing gangrene that affects the perineum, perianal, and genital regions, but spares the testicles, bladder, and rectum due to their independent blood supply from the aorta. The purpose of this research is to share our experience managing 32 cases. Patients and method: Between April 2018 and May 2022, researchers from Government Medical College in Nizamabad conducted a prospective cross-sectional study of patients with FG. During the study period, all individuals diagnosed with FG and treated for it were included. Age, sex, hospital stay, premorbid conditions, mobility, mortality, laboratory examinations, and therapies performed are among the data collected from these. Results: A total of 38 patients were seen throughout the study, with four patients being eliminated due to missing data, leaving 32 patients for the final analysis. With a male to female ratio of 15:1, there were 30 (93.75%) males and 2 (6.25%) females.
In silico Characterization, ADMET prediction and Molecular Docking studies of few 2/3 carboxylate-4/5/6-monosubstitued indole derivatives as potential GSK-3β inhibitors
Authors: Dandagvhal Kamlesh , Chatpalliwar Vivekanand
Published: July 2022

Diabetes Mellitus is a leading cause of high mortality rate in the world. Recently, GSK-3β inhibitors showed promising results to treat Diabetes mellitus and several such molecules are in clinical trials. Ethyl 2/3-carboxylate-4/5/6-monosubstituted-1H-indole derivatives were designed with the aim to search new lead molecules. The molecular structures were drawn in ChemBiodraw Ultra© and molecular docking studies were performed by using Schrödinger and AutoDock 1.5.6 software. Few in silico properties such as Log P and toxicity profile were predicted online using SwissADME and PreADMET respectively. Amongst all the designed molecules, few derivatives showed maximum binding affinity in LBD of 6V6L protein. The lipophilic character of the molecules was predicted through their individual Log P Values; molecules with better binding affinities in LBD displayed Log P values of 2.25-3.13. Additionally, some of the designed molecules were subjected to PreADMET for predicting their safety and few were predicted to induce toxic reaction were as others were predicted to be safe in the models that were selected for prediction. Ethyl 2/3-carboxylate-4/5/6-monosubstituted-1H-indole derivative were designed resulting in new molecules with high binding affinities, also few of these molecules were predicted to be non-carcinogenic with low Log P values.
Branding as an identity of place in contemporary cities
Authors: Ali Narjis Hussain , Al-Khafaji Saba J. Neamah
Published: July 2022

Cities today compete with each other to achieve urban, economic, social, cultural and political development. Thus, place-branding strategies have become necessary for cities to thrive economically and achieve a better quality of life. The study aims to provide knowledge about the concept of the place branding and the ways to achieve it and the mechanism of implementation through urban design strategies and the role of the concept in shaping or enhancing the identity of the place. This research clarifies a problem (the lack of comprehensiveness of the available knowledge about the concept of the branding and its impact on shaping or enhancing the identity of the place in contemporary cities) assuming that (the brand and the ways to achieve it have an important role in promoting and forming the identity of the place in contemporary cities). The research concluded that the brand of the place and its effectiveness stems from the identity of the place and is linked to the rooted core values of the place. The research also reached a set of urban design strategies used in achieving the brand of the place.
survey of plant disease detection techniques based on image processing and machine learning
Authors: Kumar Ravindar , Jindal Vikas
Published: July 2022

The Plant disease identification is the key which prevent loss and improve quality of the agriculture products. The plant disease detection techniques have various phases which include pre-processing, segmentation, feature extraction and classification. In the pre-processing stage, the contrast of the input image is increased. The points which are not visible are highlighted. The second stage is the segmentation which can help in selecting the region of interest. The feature extraction phase will extract relevant features of the plant. In the last phase, classification algorithm will be applied which can predict name of the disease. The various schemes are already being proposed for the plant disease detection. In this paper, plant disease detection schemes are reviewed in terms of methodologies and outcomes.
Awareness and willingness to participate in domestic waste disposal in Mumbai Region
Authors: Tariq Maryam Hanzala , D’Silva Bernadette , Lala Faiza
Published: July 2022

Domestic waste disposal is considered to be one the causes of environmental pollution and can be associated to various health problems. Proper waste management and disposal of household waste is a major concern of many people. Research Objective: The objective of this survey was to assess the level of awareness and to identify the willingness to change towards the domestic waste disposal amongst the people. Research Design: An exploratory research was done using a semi-structured questionnaire. Using simple random sampling method, a total of 204 respondents were studied. Data was analyzed using the SPSS software. Findings: In the study 84.8% were aware of the term Domestic waste disposal Management while the rest 15.2 % were not aware at all of the term. Around 51.5% says that they have been given proper education on the domestic waste disposal. About 64.2% responded by saying that are very well aware that domestic waste requires a special treatment before disposal rest of the study population were not familiar with its’ proper disposal.
Yammatawa Community Community in kebbi State, Nigeria and School Dropout Syndrome
Authors: Bin Hassan Zainudin , Said Bashiru Musa
Published: July 2022

The study looked at secondary school dropout in the Yammatawa Communities of Nigeria’s Kebbi State. The study was conducted to examine how demographic traits and educational factors affect secondary school dropout in Kebbi State, specifically in the Yammatawa areas. With more than 11,000 secondary school shuttered, 18.5 million student dropout of school in Nigeria in 2020 report stated. 6,167 dropout students from the academic year 2020-2021 made up the study’s population. For data collection 400 dropout were employed. Data gathering methods included using student records, a class attendance log, and a structured questionnaire. In order to address the study questions, the acquired data were statistically analyzed, and the Pearson product moment correlation was employed to test the hypothesis. The study discovered that there were a number of trends that contributed to dropout rates. It is clear that there is no one reason why kids drop out of school; rather, a variety of factors interact with one another in a complex manner. The consequences of the secondary school dropout rate are that it will have a variety of effects on community and national educational development.
To evaluate of antioxidant activity of Costus igneus in ethanol induced peroxidative damage in albino rats
Authors: Dhone P. G , Manish Goyal. , Sahu Y. P , Mubeen Mohd. Faheem
Published: July 2022

The free radical oxidants such as reactive oxygen species, reactive nitrogen species, and reactive sulphur species are produced inside cells through various metabolic processes. The body is equipped with an antioxidant defence system that guards against oxidative damage caused by these reactive oxidants and plays a major role in protecting cells from oxidative stress and damage. Costus igneus possess various pharmacological activities like hypolipidemic, diuretic, antioxidant, anti-microbial, anti-cancerous. Preparation of Costus igneus leaves extract. The leaves of CI were collected from the plants grown. The leaves then were shade-dried and finely powdered; the ethanolic extract is obtained by Soxhlet extraction (20 g in 100 ml of 95% ethanol at 55 °C). The rats were divided into four groups:  Group I: Normal Control rats received 0.9% normal saline.  Group II: Ethanol (20% w/v of 2g/kg body weight). Group III: 20% w/v of 2g/kg ethanol + ethanolic extract of Costus igneus 300 mg/kg body weight.  Group IV: 20% w/v of 2g/kg ethanol + ethanolic extract of Costus igneus 600 mg/kg body weight. All the study groups received treatment through oral route for thirty days at a constant volume of 10 ml/kg.
Role of optimism in attitude towards self
Authors: Rawat Rohan , Mahapatra Mamata , Bhardwaj Gopa
Published: July 2022

Optimism has proven to be an effective coping and recovery tool in many situations. The review suggests a wide variety in the revealed predominance of psychiatric morbidity and behavioural issues in Indian adolescents. Will optimism be regulative in the self-punitive attitudes of depressed adolescents? Self-punitive attitudes involve- holding overly high standards, being self-critical at any failure to perform well, and generalizing from a single failure to a broader sense of self-worth, which is usually characteristic of depressed people. The current study aims to understand the role of optimism in the Indian urban older adolescents’ attitudes towards self. A sample of one hundred and ninety-two older adolescents (50% males and 50% females) aged between fifteen to nineteen years residing in the Noida region of NCR Delhi, was taken for this study. Results revealed that optimism has a significant negative association with self-criticism and generalization. Furthermore, maximum likelihood estimates indicated that optimism significantly predicts self-criticism and generalization. Although no significant effect or association was observed on high standards, optimism may play a vital role in preventing adolescents’ cognitive contaminants of depression.
Evaluating the level of primary school students in the light of reading skills
Authors: Hatem Zainab Adnan , Hide Arif Hatem , Al-Khafaji Zina Ghani Abdul Hussein
Published: July 2022

The aim of the current research is to (evaluating the level of primary school students in the light of reading skills), and to achieve this, the researcher relied on the descriptive approach, and a research tool was built, which is the questionnaire, which consisted of (22) paragraphs distributed on six main skills: recognition, pronunciation, understanding, taste, criticism. , the evaluation and put three alternatives for each paragraph (available, available to some extent, not available), and the researcher made sure of the validity and reliability of the tool. , Hashemite District, amounted to (382) male and female students for the academic year (2021-2022 AD) and after applying the tool and unloading the data, analyzing it and treating it statistically with the Statistical Package for Social Sciences (SPSS).The researcher reached a number of results, the most important of which are: The level of availability of reading skills for primary school students (fifth grade of primary school) was very poor
Analysis of the Arabic reading book for the sixth grade of primary school in the light of the concepts of intellectual security
Authors: Majeed Firas Ismaeel , Hussein Saif Tariq
Published: July 2022

The current research aims to analyze the poetic evidence included in the Arabic grammar book for the sixth literary grade in the light of aesthetic values. They set out to analyze the poetic evidence in the Arabic grammar book for the sixth literary class, and to ensure the stability of the analysis they used two methods: the first: analysis by another analyst, and the second: re-analysis between the researcher and himself after a specified period of time amounting to (14) days, and for the purpose of extracting the results he used frequencies and ratios The percentage of the domains of aesthetic values ​​and their sub-values, and comparing them with the percentage of the hypothetical mean to find out whether they are achieved or not. The results resulted in the realization of the field of (intellectual aesthetic values) with a percentage of (45.13%) and the failure of the rest of the fields.
Factors responsible for default among patients under the revised national tuberculosis control programme
Authors: Kumar Vikash , Ojha Vivek Anand
Published: July 2022

Tuberculosis (TB) is an infectious disease caused by bacillus Mycobacterium tuberculosis. It infects the lungs and causes pulmonary tuberculosis. But it can affect any organ in the human body. Defaulting from treatment has been one of the major obstacles to treatment management and an important challenge for tuberculosis control programmes. Defaulting from therapy is the main reason for its prevalence in our society, leading to relapse and multi-drug resistance TB cases.  This study has been done to determine the causes of default among patients undergoing treatment under the Revised National Tuberculosis Control Programme (RNTCP) and their rectification.
El Liderazgo en la Administracion de Empresas
Authors:   Universidad técnica de Manabí, Portoviejo, Ecuador., PALMA MACÍAS GREGORIO RIGOBERTO , MENDOZA SALTOS MARÍA FERNANDA ,   Universidad técnica de Manabí, Portoviejo, Ecuador.
Published: July 2022

La presente investigación pretende dar un panorama sobre las consideraciones del liderazgo en un contexto organizacional, y su vinculación intrínseca con la administración de empresas. Mediante una investigación de tipo documental bibliográfica, en la cual se revisaron diferentes tipos de fuentes, artículos científicos, libros, trabajos de grado, entre otros que proporcionan conceptualizaciones que ayudan a conocer y definir los diferentes aspectos del la investigación y que pudieran dar una visión general del tema en cuestión, se pudo conocer que el liderazgo es una cualidad importante y muy útil para lograr llevar a feliz término los objetivos que se planteen en una determinada organización, de igual manera se entiende que la aplicación de las herramientas que aporta la administración para dirigir empresas u organizaciones son piezas fundamentales para que los planes y metas de negocios se logren, esto unido al liderazgo efectivo que logren los gerentes o encargados de las empresas son el engranaje que llevara a las organizaciones a la constante evolución financiera y mantendrá la sustentabilidad de sus procesos, mediante planes de trabajo congruentes con la actualidad del mercado y a tono con las exigencias de la competencia.
El Neuromarketing en la actualidad, ventajas e influencia en los consumidores
Authors:   Instituto Superior Tecnológico 17 de Julio, Ecuador., PINZÓN BARRIGA LUIS ENRIQUE , VITERI RADE LAYLA YASMINA ,   Instituto Superior Tecnológico Euroamericano, Ecuador.
Published: July 2022

El uso del Neuromarketing vino a marcar un antes y un después en el mundo del marketing, pasando de técnicas tradicionales para saber las preferencias de los consumidores, a técnicas que permite a través de herramientas tecnológicas identificar diferentes estímulos, obtener información sobre las conductas de los usuarios o consumidores antes, durante y luego de adquirir el producto o servicio, con ello garantizar la apropiación y fidelidad de la marca. Es por esta razón que surge la necesidad de analizar con esta información, los ítems más relevantes sobre el Neuromarketing así como las ventajas, su impacto en el consumidor, las herramientas tecnológicas usadas e inclusive visualizar hacia donde lleva esta herramienta. La metodologia utilizada se basa en un diseño bibliografico de tipo documental, a través de la cual se realiza una revisión de artículos científicos para una vez obtenida la aproximación epistemológica a través de dichas fuentes, concluir que, las organizaciones deben mantenerse actualizadas con respecto a las técnicas que ofrece el Neuromarketing a fin de permanecer en el tope de la publicidad.
Pinceladas del Comercio Internacional
Authors:   Universidad Estatal de Guayaquil, Guayaquil, Ecuador., SURIAGA SÁNCHEZ MARCO ANTONIO , HIDALGO HIDALGO WASHINGTON AURELIO ,   Universidad Estatal de Guayaquil, Guayaquil, Ecuador.
Published: July 2022

Durante los últimos tiempos, el desarrollo económico de los pueblos viene dado por el intercambio de productos que se produce entre ellos, es decir, los bienes o servicios que producen un pueblo pueden ser adquirido por aquellos que no lo producen, produciéndose el intercambio por otro producto u otras formas de pagos, ahora bien, cuando ese intercambio se realiza entre otros países del mundo, estamos ante la presencia del comercio internacional. Es por la importancia que reviste a este intercambio para el crecimiento de los pueblos, que esta investigación se torna útil a fin de para asumir una cosmovisión del comercio internacional, con pinceladas de su epistemología teórica, importancia, ventajas y desventajas, caracterización y realizar de un corto viaje por América Latina. Para ello se utilizó una metodologia basada en el diseño bibliografico de tipo documental, a través de la cual se realiza una revisión sistemática de artículos científicos para una vez logrado un basamento general del comercio internacional concluir que a pesar de las crisis económicas actuales causadas por eventos mundiales como el Covid-19, el mercado internacional sigue contribuyendo al crecimiento económico, social, político y hasta cultural de los pueblos.