bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis
Authors: Tsurusaki Shinya , Tsuchiya Yuichi , Koumura Tomoko , Nakasone Misaki , Sakamoto Taro , Matsuoka Masaki , Imai Hirotaka , Yuet-Yin Kok Cindy , Okochi Hitoshi , Nakano Hiroyasu , Miyajima Atsushi , Tanaka Minoru
Published: June 2019

Nonalcoholic steatohepatitis (NASH) is a metabolic liver disease that progresses from simple steatosis to the disease state of inflammation and fibrosis. Previous studies suggest that apoptosis and necroptosis may contribute to the pathogenesis of NASH, based on several murine models. However, the mechanisms underlying the transition of simple steatosis to steatohepatitis remain unclear, because it is difficult to identify when and where such cell deaths begin to occur in the pathophysiological process of NASH. In the present study, our aim is to investigate which type of cell death plays a role as the trigger for initiating inflammation in fatty liver. By establishing a simple method of discriminating between apoptosis and necrosis in the liver, we found that necrosis occurred prior to apoptosis at the onset of steatohepatitis in the choline-deficient, ethionine-supplemented (CDE) diet model. To further investigate what type of necrosis is involved in the initial necrotic cell death, we examined the effect of necroptosis and ferroptosis inhibition by administering inhibitors to wild-type mice in the CDE diet model. In addition, necroptosis was evaluated using mixed lineage kinase domain-like protein (MLKL) knockout mice, which is lacking in a terminal executor of necroptosis. Consequently, necroptosis inhibition failed to block the onset of necrotic cell death, while ferroptosis inhibition protected hepatocytes from necrotic death almost completely, and suppressed the subsequent infiltration of immune cells and inflammatory reaction. Furthermore, the amount of oxidized phosphatidylethanolamine, which is involved in ferroptosis pathway, was increased in the liver sample of the CDE diet-fed mice. These findings suggest that hepatic ferroptosis plays an important role as the trigger for initiating inflammation in steatohepatitis and may be a therapeutic target for preventing the onset of steatohepatitis.
RETRACTED ARTICLE: miR-381 modulates human bone mesenchymal stromal cells (BMSCs) osteogenesis via suppressing Wnt signaling pathway during atrophic nonunion development
Authors: Long Haitao , Zhu Yong , Lin Zhangyuan , Wan Jun , Cheng Liang , Zeng Min , Tang Yifu , Zhao Ruibo
Published: June 2019

The osteogenic differentiation of human bone mesenchymal stromal cells (BMSCs) has been considered as a central issue in fracture healing. Wnt signaling could promote BMSC osteogenic differentiation through inhibiting PPARγ. During atrophic nonunion, Wnt signaling-related factors, WNT5A and FZD3 proteins, were significantly reduced, along with downregulation of Runx2, ALP, and Collagen I and upregulation of PPARγ. Here, we performed a microarray analysis to identify differentially expressed miRNAs in atrophic nonunion tissues that were associated with Wnt signaling through targeting related factors. Of upregulated miRNAs, miR-381 overexpression could significantly inhibit the osteogenic differentiation in primary human BMSCs while increase in PPARγ protein level. Through binding to the 3′UTR of WNT5A and FZD3, miR-381 modulated the osteogenic differentiation via regulating β-catenin nucleus translocation. Moreover, PPARγ, an essential transcription factor inhibiting osteogenic differentiation, could bind to the promoter region of miR-381 to activate its expression. Taken together, PPARγ-induced miR-381 upregulation inhibits the osteogenic differentiation in human BMSCs through miR-381 downstream targets, WNT5A and FZD3, and β-catenin nucleus translocation in Wnt signaling. The in vivo study also proved that inhibition of miR-381 promoted the fracture healing. Our finding may provide a novel direction for atrophic nonunion treatment.
Mitotically heritable effects of BMAA on striatal neural stem cell proliferation and differentiation
Authors: Pierozan Paula , Karlsson Oskar
Published: June 2019

The widespread environmental contaminant β-methylamino-L-alanine (BMAA) is a developmental neurotoxicant that can induce long-term learning and memory deficits. Studies have shown high transplacental transfer of 3H-BMAA and a significant uptake in fetal brain. Therefore, more information on how BMAA may influence growth and differentiation of neural stem cells is required for assessment of the risk to the developing brain. The aim of this study was to investigate direct and mitotically inherited effects of BMAA exposure using primary striatal neurons and embryonic neural stem cells. The neural stem cells were shown to be clearly more susceptible to BMAA exposure than primary neurons. Exposure to 250 µM BMAA reduced neural stem cell proliferation through apoptosis and G2/M arrest. At lower concentrations (50–100 µM), not affecting cell proliferation, BMAA reduced the differentiation of neural stem cells into astrocytes, oligodendrocytes, and neurons through glutamatergic mechanisms. Neurons that were derived from the BMAA-treated neuronal stem cells demonstrated morphological alterations including reduced neurite length, and decreased number of processes and branches per cell. Interestingly, the BMAA-induced changes were mitotically heritable to daughter cells. The results suggest that early-life exposure to BMAA impairs neuronal stem cell programming, which is vital for development of the nervous system and may result in long-term consequences predisposing for both neurodevelopmental disorders and neurodegenerative disease later in life. More attention should be given to the potential adverse effects of BMAA exposure on brain development.
Author Correction: Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration
Authors: Luo Xiaoying , Wang Dan , Zhu Xintao , Wang Guozhen , You Yuehua , Ning Zuowei , Li Yang , Jin Siyi , Huang Yun , Hu Ye , Chen Tingting , Meng Ying , Li Xu
Published: June 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns
Authors: Shetty Amol C. , Jacob Christopher G. , Huang Fang , Li Yao , Agrawal Sonia , Saunders David L. , Lon Chanthap , Fukuda Mark M. , Ringwald Pascal , Ashley Elizabeth A. , Han Kay Thwe , Hlaing Tin Maung , Nyunt Myaing M. , Silva Joana C. , Stewart Kathleen E. , Plowe Christopher V. , O’Connor Timothy D. , Takala-Harrison Shannon ,   Artemisinin Resistance Confirmation, Characterization, and Containment (ARC3), Noedl Harald , Khan Wasif A. ,   Artemisinin Resistance Containment and Elimination (ARCE), Newton Paul , Kyaw Myat P. ,   Tracking Resistance to Artemisinin Collaboration (TRAC), White Nicholas J. , Dondorp Arjen M. , Day Nicholas P. , Woodrow Charles J. , Dhorda Mehul , Faiz M. Abul , Fairhurst Rick M. , Lim Pharath , Tripura Rupam , Mayxay Mayfong , Htut Ye , Nosten Francois , Phyo Aung Pyae , Pukrittayakamee Sasithon , Hien Tran Tinh , Nhien Nguyen Thanh Thuy , Mokuolu Olugbenga A. , Fanello Caterina I. , Onyamboko Marie A.
Published: June 2019

Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.
Force-driven reversible liquid–gas phase transition mediated by elastic nanosponges
Authors: Nomura Keita , Nishihara Hirotomo , Yamamoto Masanori , Gabe Atsushi , Ito Masashi , Uchimura Masanobu , Nishina Yuta , Tanaka Hideki , Miyahara Minoru T. , Kyotani Takashi
Published: June 2019

Nano-confined spaces in nanoporous materials enable anomalous physicochemical phenomena. While most nanoporous materials including metal-organic frameworks are mechanically hard, graphene-based nanoporous materials possess significant elasticity and behave as nanosponges that enable the force-driven liquid–gas phase transition of guest molecules. In this work, we demonstrate force-driven liquid–gas phase transition mediated by nanosponges, which may be suitable in high-efficiency heat management. Compression and free-expansion of the nanosponge afford cooling upon evaporation and heating upon condensation, respectively, which are opposite to the force-driven solid–solid phase transition in shape-memory metals. The present mechanism can be applied to green refrigerants such as H2O and alcohols, and the available latent heat is at least as high as 192 kJ kg−1. Cooling systems using such nanosponges can potentially achieve high coefficients of performance by decreasing the Young’s modulus of the nanosponge.
Author Correction: Limited capacity of tree growth to mitigate the global greenhouse effect under predicted warming
Authors: Büntgen Ulf , Krusic Paul J. , Piermattei Alma , Coomes David A. , Esper Jan , Myglan Vladimir S. , Kirdyanov Alexander V. , Camarero J. Julio , Crivellaro Alan , Körner Christian
Published: June 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: The pleasantness of sensory dissonance is mediated by musical style and expertise
Authors: Popescu Tudor , Neuser Monja P. , Neuwirth Markus , Bravo Fernando , Mende Wolfgang , Boneh Oren , Moss Fabian C. , Rohrmeier Martin
Published: June 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Analysis of whole Y-chromosome sequences reveals the Japanese population history in the Jomon period
Authors: Watanabe Yusuke , Naka Izumi , Khor Seik-Soon , Sawai Hiromi , Hitomi Yuki , Tokunaga Katsushi , Ohashi Jun
Published: June 2019

The Jomon and the Yayoi are considered to be the two major ancestral populations of the modern mainland Japanese. The Jomon people, who inhabited mainland Japan, admixed with Yayoi immigrants from the Asian continent. To investigate the population history in the Jomon period (14,500–2,300 years before present [YBP]), we analyzed whole Y-chromosome sequences of 345 Japanese males living in mainland Japan. A phylogenetic analysis of East Asian Y chromosomes identified a major clade (35.4% of mainland Japanese) consisting of only Japanese Y chromosomes, which seem to have originated from indigenous Jomon people. A Monte Carlo simulation indicated that ~70% of Jomon males had Y chromosomes in this clade. The Bayesian skyline plots of 122 Japanese Y chromosomes in the clade detected a marked decrease followed by a subsequent increase in the male population size from around the end of the Jomon period to the beginning of the Yayoi period (2,300 YBP). The colder climate in the Late to Final Jomon period may have resulted in critical shortages of food for the Jomon people, who were hunter-gatherers, and the rice farming introduced by Yayoi immigrants may have helped the population size of the Jomon people to recover.
Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor β2 in a new conformation
Authors: del Amo-Maestro Laura , Marino-Puertas Laura , Goulas Theodoros , Gomis-Rüth F. Xavier
Published: June 2019

Transforming growth factor β is a disulfide-linked dimeric cytokine that occurs in three highly related isoforms (TGFβ1–TGFβ3) engaged in signaling functions through binding of cognate TGFβ receptors. To regulate this pathway, the cytokines are biosynthesized as inactive pro-TGFβs with an N-terminal latency-associated protein preceding the mature moieties. Due to their pleiotropic implications in physiology and pathology, TGFβs are privileged objects of in vitro studies. However, such studies have long been limited by the lack of efficient human recombinant expression systems of native, glycosylated, and homogenous proteins. Here, we developed pro-TGFβ2 production systems based on human Expi293F cells, which yielded >2 mg of pure histidine- or Strep-tagged protein per liter of cell culture. We assayed this material biophysically and in crystallization assays and obtained a different crystal form of mature TGFβ2, which adopted a conformation deviating from previous structures, with a distinct dimeric conformation that would require significant rearrangement for binding of TGFβ receptors. This new conformation may be reversibly adopted by a certain fraction of the mature TGβ2 population and represent a hitherto undescribed additional level of activity regulation of the mature growth factor once the latency-associated protein has been separated.
Simulating human exposure to indoor airborne microplastics using a Breathing Thermal Manikin
Authors: Vianello Alvise , Jensen Rasmus Lund , Liu Li , Vollertsen Jes
Published: June 2019

Humans are potentially exposed to microplastics through food, drink, and air. The first two pathways have received quite some scientific attention, while little is known about the latter. We address the exposure of humans to indoor airborne microplastics using a Breathing Thermal Manikin. Three apartments were investigated, and samples analysed through FPA-µFTIR-Imaging spectroscopy followed by automatic analyses down to 11 µm particle size. All samples were contaminated with microplastics, with concentrations between 1.7 and 16.2 particles m−3. Synthetic fragments and fibres accounted, on average, for 4% of the total identified particles, while nonsynthetic particles of protein and cellulose constituted 91% and 4%, respectively. Polyester was the predominant synthetic polymer in all samples (81%), followed by polyethylene (5%), and nylon (3%). Microplastics were typically of smaller size than nonsynthetic particles. As the identified microplastics can be inhaled, these results highlight the potential direct human exposure to microplastic contamination via indoor air.
Comparative genomics of chytrid fungi reveal insights into the obligate biotrophic and pathogenic lifestyle of Synchytrium endobioticum
Authors: van de Vossenberg Bart T. L. H. , Warris Sven , Nguyen Hai D. T. , van Gent-Pelzer Marga P. E. , Joly David L. , van de Geest Henri C. , Bonants Peter J. M. , Smith Donna S. , Lévesque C. André , van der Lee Theo A. J.
Published: June 2019

Synchytrium endobioticum is an obligate biotrophic soilborne Chytridiomycota (chytrid) species that causes potato wart disease, and represents the most basal lineage among the fungal plant pathogens. We have chosen a functional genomics approach exploiting knowledge acquired from other fungal taxa and compared this to several saprobic and pathogenic chytrid species. Observations linked to obligate biotrophy, genome plasticity and pathogenicity are reported. Essential purine pathway genes were found uniquely absent in S. endobioticum, suggesting that it relies on scavenging guanine from its host for survival. The small gene-dense and intron-rich chytrid genomes were not protected for genome duplications by repeat-induced point mutation. Both pathogenic chytrids Batrachochytrium dendrobatidis and S. endobioticum contained the largest amounts of repeats, and we identified S. endobioticum specific candidate effectors that are associated with repeat-rich regions. These candidate effectors share a highly conserved motif, and show isolate specific duplications. A reduced set of cell wall degrading enzymes, and LysM protein expansions were found in S. endobioticum, which may prevent triggering plant defense responses. Our study underlines the high diversity in chytrids compared to the well-studied Ascomycota and Basidiomycota, reflects characteristic biological differences between the phyla, and shows commonalities in genomic features among pathogenic fungi.
Publisher Correction: Revealing membrane alteration in cells overexpressing CA IX and EGFR by Surface-Enhanced Raman Scattering
Authors: Rusciano Giulia , Sasso Emanuele , Capaccio Angela , Zambrano Nicola , Sasso Antonio
Published: June 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Construction of sulfur-containing moieties in the total synthesis of natural products
Authors: Wang Nengzhong , Saidhareddy Puli , Jiang Xuefeng
Published: June 2019

This review surveys the total syntheses of sulfur-containing natural products where sulfur atoms are introduced with different sulfurization agents to construct related sulfur-containing moieties.
Disposable electrochemical biosensor based on surface-modified screen-printed electrodes for organophosphorus pesticide analysis
Authors: Hua Quoc Trung , Ruecha Nipapan , Hiruta Yuki , Citterio Daniel
Published: June 2019

Sensitive and long-term stable disposable biosensor for organophosphorus analysis.
Synthesis of azonia cyanine derivatives as NIR fluorescent probes for nucleic acid detection and cell imaging
Authors: Chen Yuan , Wei Xue-Rui , Sun Ru , Xu Yu-Jie , Ge Jian-Jeng
Published: June 2019

A series of azonia cyanine dyes were designed and synthesized for nucleic acid detection and nucleolus imaging in fixed HeLa cells.
Correction: Synthesis of a monodisperse well-defined core–shell magnetic molecularly-imprinted polymer prior to LC-MS/MS for fast and sensitive determination of mycotoxin residues in rice
Authors: Pan Sheng-Dong , Ye Mei-Jun , Gao Guo-Sheng , He Qian , Wang Li , Chen Xiao-Hong , Qiu Qiao-Li , Jin Mi-Cong
Published: June 2019

Correction for ‘Synthesis of a monodisperse well-defined core–shell magnetic molecularly-imprinted polymer prior to LC-MS/MS for fast and sensitive determination of mycotoxin residues in rice’ by Sheng-Dong Pan et al., Anal. Methods, 2017, 9, 5281–5292.
Catalytic transformation of 2,5-furandicarboxylic acid to adipic acid over niobic acid-supported Pt nanoparticles
Authors: Wei Longfu , Zhang Junxian , Deng Weiping , Xie Shunji , Zhang Qinghong , Wang Ye
Published: June 2019

Biomass-derived 2,5-furandicarboxylic acid was successfully converted to adipic acid over a niobic acid-supported Pt catalyst in water under H2.
Influence of methyl-substitution on the dynamics of the C–H⋯F–C interaction in binary adducts
Authors: Cockcroft Jeremy K. , Li Jacqueline G. Y. , Williams Jeffrey H.
Published: June 2019

Variable-temperature X-ray diffraction has been used to probe structure and dynamics of two solid adducts formed by hexafluorobenzene with toluene andp-xylene.
Influence of framework Si/Al ratio and topology on electron transfers in zeolites
Authors: Crémoux T. , Batonneau-Gener I. , Moissette A. , Paillaud J.-L. , Hureau M. , Ligner E. , Morais C. , Laforge S. , Marichal C. , Nouali H.
Published: June 2019

From experimental results on H-ZSM-5 and H-*BEA zeolites, it is shown that the stability of radical cations and of charge transfer complexes (CTC) is highly dependent on the distance between Brønsted sites and strong Lewis sites or Brønsted Strong Lewis Pairs (BSLPs).
A mini review ofin situnear-ambient pressure XPS studies on non-noble, late transition metal catalysts
Authors: Zhong Liping , Chen Dingkai , Zafeiratos Spyridon
Published: June 2019

The rich surface chemistry of Fe, Co, Ni and Cu during heterogeneous catalytic reactions from the perspective of NAP-XPS studies.
Direct coating copper–zinc–aluminum oxalate with H-ZSM-5 to fabricate a highly efficient capsule-structured bifunctional catalyst for dimethyl ether production from syngas
Authors: Sun Yingqi , Han Xinghua , Zhao Zhongkui
Published: June 2019

This work reports a facile strategy for preparing a highly efficient capsule bifunctional catalyst by direct coating copper–zinc–aluminum oxalate with H-ZSM-5, showing outstanding catalytic properties for dimethyl ether production from syngas.
Formation of CeSiO4 from cerium(iii) silicate precursors
Authors: Estevenon Paul , Kaczmarek Thibault , Vadot Fabien , Dumas Thomas , Solari Pier Lorenzo , Welcomme Eleonore , Szenknect Stephanie , Mesbah Adel , Moisy Philippe , Poinssot Christophe , Dacheux Nicolas
Published: June 2019

Pure CeSiO4 (zircon type) was prepared by hydrothermal conversion of Ce(iii) silicate based solid precursors A-Ce2Si2O7 or Ce4.67(SiO4)3O.
A biochemometric approach for the assessment ofPhyllanthus emblicafemale fertility effects as determinedviaUPLC-ESI-qTOF-MS and GC-MS
Authors: Khaled Sally E. , Hashem Fatma A.-M. , Shabana Manal H. , Hammam Abdel-Mohsen M. , Madboli Abdel Nasser A. , Al-Mahdy Dalia A. , Farag Mohamed A.
Published: June 2019

Phyllanthus emblicaL. fruits have long been used in Ayurvedic medicine for their many health benefits.
Unlocking the response of lignin structure for improved carbon fiber production and mechanical strength
Authors: Zhang Ran , Du Qing , Wang Lei , Zheng Ze , Guo Li , Zhang Xiaoyu , Yang Xiangliang , Yu Hongbo
Published: June 2019

Soda lignin, a more linear polymer, blended with PAN could produce more carbon fibers with doubled tensile stress.
Disease-specific protein corona sensor arrays may have disease detection capacity
Authors: Caracciolo Giulio , Safavi-Sohi Reihaneh , Malekzadeh Reza , Poustchi Hossein , Vasighi Mahdi , Zenezini Chiozzi Riccardo , Capriotti Anna Laura , Laganà Aldo , Hajipour Mohammad , Di Domenico Marina , Di Carlo Angelina , Caputo Damiano , Aghaverdi Haniyeh , Papi Massimiliano , Palmieri Valentina , Santoni Angela , Palchetti Sara , Digiacomo Luca , Pozzi Daniela , Suslick Kenneth S. , Mahmoudi Morteza
Published: June 2019

Protein corona sensor array technology identifies diseases through specific proteomics pattern recognition.
Recent advances and applications of p-toluenesulfonylmethyl isocyanide (TosMIC)
Authors: Mathiyazhagan Arun Divakar , Anilkumar Gopinathan
Published: June 2019

TosMIC, a unique and multifunctional synthetic reagent, reacts with a wide spectrum of synthons to deliver novel scaffolds.
Iridium-catalyzed intramolecular enantioselective allylation of quinazolin-4(3H)-one derivatives
Authors: Peng Fei , Tian Hua , Zhang Pengxiang , Yang Haijun , Fu Hua
Published: June 2019

An efficient chiral cyclic phosphoramidite ligand-enabled iridium-catalyzed intramolecular allylation of quinazolin-4(3H)-one derivatives has been developed with high reactivity and high to excellent enantioselectivity.
Domino enyne metathesis en route to skeletally diverse, privileged scaffolds: synthesis of the tricyclic core of pseudolaric acid F
Authors: Lin Minggui , Cui Hao , Hua Yuhui , Zhang Yandong
Published: June 2019

A domino enyne metathesis strategy for the efficient synthesis of skeletally diverse, privileged scaffolds has been developed.
Correction: Enhanced thermal conductance at the graphene–water interface based on functionalized alkane chains
Authors: Chen Shuyu , Yang Ming , Liu Bin , Xu Min , Zhang Teng , Zhuang Bilin , Ding Ding , Huai Xiulan , Zhang Hang
Published: June 2019

Correction for ‘Enhanced thermal conductance at the graphene–water interface based on functionalized alkane chains’ by Shuyu Chen et al., RSC Adv., 2019, 9, 4563–4570.
Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives
Authors: Chen Zhi-Min , Liu Jianbo , Guo Jing-Yao , Loch Maximillan , DeLuca Ryan J. , Sigman Matthew S.
Published: June 2019

A regioselective and enantioselective palladium-catalyzed relay Heck alkenylation of alkenylbenzene derivatives to construct remote stereocenters is disclosed.
A general concept for the introduction of hydroxamic acids into polymers
Authors: Johann Tobias , Keth Jennifer , Bros Matthias , Frey Holger
Published: June 2019

Polyethers (PEG) with hydroxamic acid groups enable chelation of a variety of metal ions, coating of metal oxide surfaces and stabilization of nanoparticles. In contrast to catechol, hydroxamic acids are oxidation stable and biocompatible.
Adding available nitrogen and carbon can improve the efficiency of oil displacement with indigenous bacterial flooding
Authors: Gao Hui , Lai Hangxian , Zhang Junhui , Xue Quanhong
Published: June 2019

In this study, simulated oil displacement tests were performed to investigate the effects of addition of readily available nitrogen and carbon nutrients on indigenous bacterial growth and crude oil displacement.
Resistance-based analysis of limiting interfaces in multilayer water splitting photocathodes by impedance spectroscopy
Authors: Moehl Thomas , Cui Wei , Wick-Joliat René , Tilley S. David
Published: June 2019

Electrochemical impedance spectroscopy is used to determine the potential-dependent resistances in multilayer photocathodes for water splitting. Limitations in the devices can thereby be identified and improvements proposed and investigated.
Correction: Controlled synthesis of pentachlorophenol-imprinted polymers on the surface of magnetic graphene oxide for highly selective adsorption
Authors: Pan Sheng-Dong , Shen Hao-Yu , Zhou Li-Xin , Chen Xiao-Hong , Zhao Yong-Gang , Cai Mei-Qiang , Jin Mi-Cong
Published: June 2019

Correction for ‘Controlled synthesis of pentachlorophenol-imprinted polymers on the surface of magnetic graphene oxide for highly selective adsorption’ by Sheng-Dong Pan et al., J. Mater. Chem. A, 2014, 2, 15345–15356.
Metabolic remodeling of cardiomyocytes identified in phosphoinositide-dependent kinase 1-deficient mice
Authors: Li Chen , Niu Yan , Zheng Hong , Shan Congjia , Chen Qinbo , Yang Zhongzhou , Zhao Liangcai , Yang Changwei , Gao Hongchang
Published: June 2019

Metabolic remodeling plays an essential role in the pathophysiology of heart failure (HF). Many studies have shown that the disruption of phosphoinositide-dependent protein kinase-1 (PDK1) caused severe and lethal HF; however, the metabolic pattern of PDK1 deletion remains ambiguous. 1H nuclear magnetic resonance-based metabolomics was applied to explore the altered metabolic pattern in Pdk1-deficient mice. Principle component analysis showed significant separation as early as 4 weeks of age, and dysfunction of metabolism precedes a morphological change in Pdk1-deficient mice. A time trajectory plot indicated that disturbed metabolic patterns were related to the pathological process of the HF in Pdk1-deficient mice, rather than the age of mice. Metabolic profiles demonstrated significantly increased levels of acetate, glutamate, glutamine, and O-phosphocholine in Pdk1 deletion mice. Levels of lactate, alanine, glycine, taurine, choline, fumarate, IMP, AMP, and ATP were significantly decreased compared with controls. Furthermore, PDK1 knockdown decreased the oxygen consumption rate in H9C2 cells as determined using a Seahorse XF96 Analyzer. These findings imply that the disruption of metabolism and impaired mitochondrial activity might be involved in the pathogenesis of HF with PDK1 deletion.
Plasma properties of suprathermal electrons near comet 67P/Churyumov-Gerasimenko with Rosetta
Authors: Myllys M. , Henri P. , Galand M. , Heritier K. L. , Gilet N. , Goldstein R. , Eriksson A. I. , Johansson F. , Deca J.
Published: June 2019

Context. The Rosetta spacecraft escorted comet 67P/Churyumov-Gerasimenko from 2014 to September 2016. The mission provided in situ observations of the cometary plasma during different phases of the cometary activity, which enabled us to better understand its evolution as a function of heliocentric distance.

Aims. In this study, different electron populations, called warm and hot, observed by the Ion and Electron Sensor (IES) of the Rosetta Plasma Consortium (RPC) are investigated near the comet during the escorting phase of the Rosetta mission.

Methods. The estimates for the suprathermal electron densities and temperatures were extracted using IES electron data by fitting a double-kappa function to the measured velocity distributions. The fitting results were validated using observations from other RPC instruments. We give upgraded estimates for the warm and hot population densities compared to values previously shown in literature.

Results. The fitted density and temperature estimates for both electron populations seen by IES are expressed as a function of heliocentric distance to study their evolution with the cometary activity. In addition, we studied the dependence between the electron properties and cometocentric distance.

Conclusions. We observed that when the neutral outgassing rate of the nucleus is high (i.e., near perihelion) the suprathermal electrons are well characterized by a double-kappa distribution. In addition, warm and hot populations show a significant dependence with the heliocentric distance. The populations become clearly denser near perihelion while their temperatures are observed to remain almost constant. Moreover, the warm electron population density is shown to be strongly dependent on the radial distance from the comet. Finally, based on our results we reject the hypothesis that hot electron population seen by IES consists of solely suprathermal (halo) solar wind electrons, while we suggest that the hot electron population mainly consists of solar wind thermal electrons that have undergone acceleration near the comet.
Offshore Wind Energy and the Romanian Energy Future
Authors: Onea Florin , Rusu Liliana
Published: June 2019

The aim of the present work is to assess the electricity production coming from an offshore wind farm that may operate in the northern part of the Romanian coastal area. In the first part, a complete description of the Romanian energy sector is presented considering the t ime interval from January 2008 to December 2018. In general, the elect ricity sold is negat ive (exports exceed imports), with the ment ion that a significant cont ribution comes from hydroelect ric and coal generat ion. It is important to ment ion that , if one of these two sectors willno longer perform on full capacity, the elect ricity balance will be shifted to the elect ricity imports. As for the wind energy, the average values from the vicinity of Sulina site may vary between 5.6 m/s and 8 m/s depending on the season, these results being reported at a wind turbine level (80 m). By using an offshore win d farm which replicates the Greater Gabbard project (504 MW), England, was possible to est imate the annual energy product ion and to indicate the expected impact on the energy sector. For example, a single wind farm may cover 1.7% of the total production, which may be further associated with 9.6% from nuclear, 7.6% from hydroelect ric or 6.4% from coal, respectively.
Kinetic analysis of Wood residues and Gorse (Ulex europaeus) pyrolysis under non-isothermal conditions: A case of study in Bogotá, Colombia
Authors: Beltrán Vivian , Martínez Laura V. , López Andrés , Gómez María F.
Published: June 2019

Thermal degradation and kinetic for biomass materials wood residues and Gorse (Ulex europaeus) have been evaluated under pyrolysis (N2) conditions, using a non-isothermal thermogravimetric method (TGA) from 25°C to 900°C at different heating rates of 10, 20, 30 and 40°C min-1. In DTG curves the temperature peaks at maximum weight loss rate changed with increasing heating rate. The maximum rate of weight loss (%s-1) was obtained at a heating rate of 40°C/min of 0,38 and 0,46 (%s-1) for wood residues and Gorse, respectively. Activation energy calculations were based on selected non-isothermal methods (Kissinger, FWO, KAS, and Starink). For Gorse, the energy activation was 195.41, 194.44, 214.39 and 179.42 kJmol-1 by Kissinger, FWO, KAS, and Starink methods, respectively. In the other hand, the energy activation for wood residues was 176.03, 221.75, 243.08 and 198.26 kJmol-1 by Kissinger, FWO, KAS, and Starink methods, respectively. The results showed that Gorse has a lower activation energy than wood residues, which represents a great potential to be used as a feedstock in thermochemical technologies. The Levelized Cost of Electricity (LCOE) was calculated for gasification of wood residues and Gorse, which was 186 and 169 USD/MWh, respectively.
Increase of Energy Potential of Russian Forest resources due to Climate Change and CO2 Fertilization
Authors: Klimenko Vladimir , Tereshin Alexei , Mikushina Olga
Published: June 2019

Biofuels are an important energy source, currently providing about 10% of the world energy demand, including 2% of global electricity generation and the same share of total liquid fuel consumption. Wood fuel in Russia is one of the most affordable and most important type of renewable energy resources. In this paper we study the possible changes in energy potential of Russia's forest resources as a result of changes in the atmosphere and climate. The estimates of the global dioxide concentrations dynamics and mean annual air temperature change over the Russian territory for the period up to 2050 are developed using the MPEI models of the carbon cycle and regional climate. The calculations show that the change of net primary productivity of forests of Russia as a result of the CO2 abundance increase in the atmosphere, as well as of the increase of the air temperature and rainfall will enhance available energy resources of wood fuel by mid-century by more than 9 million tons of coal equivalent (Mtce).
Study of the fast calorimeter prototype for the Super Charm-Tau Factory
Authors: Prokhorova Ekaterina
Published: June 2019

Modern e+e− factories with high luminosity require fast response time of the detector subsystems to collect the data eﬃciently and suppress severe beam background. The prototype of the electromagnetic calorimeter based on the counter made of pure CsI crystal, novel wavelength shifter with nanostructured organosilicon luminophores and avalanche photodiodes Hamamatsu S8664-55 is discussed. Results of the measurement of the basic characteristics of the counter are presented.
Proposal of the Muon System for the Super Tau-Charm Factory
Authors: Uglov Timofey
Published: June 2019

The first results of the Super Charm-Tau factory muon system simulation are presented: estimation of the main characteristics such as space resolution and muon identification efficiency. A design of the muon system for the Super Charm-Tau factory based on the organic scintillator + WLS fiber + SiPM is proposed.
X, Y, Z search at Belle II
Authors: Prencipe Elisabetta
Published: June 2019

The Belle II experiment has successfully concluded Phase-2 of data taking in July 2018, and just started Phase-3, with the complete detector setup. Great perspectives and unique physics cases are enhanced in the Belle II physics program. In the sector of charmonium and spectroscopy, Belle II will investigate several physics processes: ISR physics for the vector states, bottomonium search and the study of the X(3872) line shape are some examples where the contribution of the Belle II experiment will help in better understanding QCD, for which several open issues still remain unsolved. First simulations and data analyses will be shown, with the first available dataset (2018), and the plan for spectroscopy search at Belle II will be discussed.
The decay J/ψ → γX(JP) → γϕϕ: Dynamical analysis of the X(JP) → ϕϕ resonance contributions
Authors: Kozhevnikov A.A.
Published: June 2019

The dynamics of the JPC = 0-+,0++, and 2++ resonance contributions to the decay $ J/\psi {\rm{ }} \to {\rm{ }}\gamma X\left( {{J^P}} \right) \to {\rm{ }}\gamma \phi \phi $ is analysed using the data obtained by BESIII collaboration. The effective coupling constants parameterising invariant amplitudes of the transitions $ J/\psi {\rm{ }} \to {\rm{ }}\gamma X\left( {{J^{PC}}} \right) $ and $ X\left( {{J^P}} \right) \to {\rm{ }}\phi \phi $ and masses $ X\left( {{J^P}} \right) $ of found from the fits are used to plot $ \phi \phi $ the mass spectrum of each JPC component.
Meson spectroscopy at VES and COMPASS
Authors: Ryabchikov Dmitry
Published: June 2019

Diffractive production of π- π- π+ and π- π0 π0 final states is the subject of comprehensive studies performed recently by the VES and the COM-PASS experiments. COMPASS pioneered the application of novel methods of partial-wave analysis: mass-independent PWA inmultiple (m3π, t’)-cells, mass-dependent analysis of spin-density matrices performed simultaneously in all measured t’ bins, the analysis with freed shapes of π+ π- isobars. In addition, COMPASS observed a new narrow state: a1(1420). VES has world-leading data samples on π- π- π+ and π- π0 π0, that yield compatible results and show the potential for a detailed comparison of isospin relations between different decay channels, using the PWA methods with fixed and freed shapes of ππ isobars.
Study of π+π−π+π− production with CMD-3 detector at the VEPP-2000 collider
Authors: Korobov A. A. , Akhmetshin R. R. , Amirkhanov A. N. , Anisenkov A. V. , Aulchenko V. M. , Banzarov V. Sh. , Bashtovoy N. S. , Berkaev D. E. , Bondar A. E. , Bragin A. V. , Eidelman S. I. , Epifanov D. A. , Epshteyn L. B. , Erofeev A. L. , Fedotovich G. V. , Gayazov S. E. , Grebenuk A. A. , Gribanov S. S. , Grigoriev D. N. , Ignatov F. V. , Ivanov V. L. , Karpov S. V. , Kasaev A. S. , Kazanin V. F. , Koop I. A. , Korobov A. A. , Kozyrev A. N. , Kozyrev E. A. , Krokovny P. P. , Kuzmenko A. E. , Kuzmin A. S. , Logashenko I. B. , Lysenko A. P. , Lukin P. A. , Mikhailov K. Yu. , Okhapkin V. S. , Otboev A. V. , Perevedentsev E. A. , Pestov Yu. N. , Popov A. S. , Razuvaev G. P. , Ruban A. A. , Ryskulov N. M. , Ryzhenenkov A. E. , Semenov A. V. , Senchenko A. I. , Shatunov Yu. M. , Shebalin V. E. , Shemyakin D. N. , Shwartz B. A. , Shwartz D. B. , Sibidanov A. L. , Solodov E. P. , Titov V. M. , Talyshev A. A. , Vorobiov A. I. , Yudin Yu. V.
Published: June 2019

The cross section of the process e+e−→ π+π−π+π− has been measured using an integrated luminosity of 17 pb−1 collected with the CMD-3 detector in the center-of-mass energy range 650-1000 MeV. High-precision measurements of various hadronic cross sections are of great interest in relation with the problem of the muon anomalous magnetic moment g-2. This measurement can be also used to test the relation between the cross section of e+e−→ π+ π−π+ π− and the spectral function for the τ−→ π−π0π0π0 decay predicted by the conservation of vector current (CVC).
Searching for dark sector with missing mass technique in fixed target experiments
Authors: Kozhuharov Venelin
Published: June 2019

Currently, the existence of a dark sector almost completely decoupled from the Standard Model is a viable solution for numerous long-standing problems in physics, including the nature of dark matter and the muon anomalous magnetic moment. A new gauge mediator, the dark photon, could be the portal to this hidden sector. The most general probe to its existence is the missing mass technique which requires a precise knowledge of the initial state of the process but does not put constraints on the dark photon final states. The experimental approaches to the search for dark photons in positron-on-target annihilation and in mesons decay in flight are presented and the physics reach is discussed.
The NNbar and multihadron production at the threshold at VEPP2000
Authors: Solodov E. P. , Akhmetshin R. R. , Amirkhanov A. N. , Anisenkov A. V. , Aulchenko V. M. , Banzarov V. Sh. , Bashtovoy N. S. , Berkaev D. E. , Bondar A. E. , Bragin A. V. , Eidelman S. I. , Epifanov D. A. , Epshteyn L. B. , Erofeev A. L. , Fedotovich G. V. , Gayazov S. E. , Grebenuk A. A. , Gribanov S. S. , Grigoriev D. N. , Ignatov F. V. , Ivanov V. L. , Karpov S. V. , Kazanin V. F. , Koop I. A. , Kirpotin A. N. , Korobov A. A. , Kozyrev A. N. , Kozyrev E. A. , Krokovny P. P. , Kuzmenko A. E. , Kuzmin A. S. , Logashenko I. B. , Lukin P. A. , Mikhailov K. Yu. , Okhapkin V. S. , Pestov Yu. N. , Popov A. S. , Razuvaev G. P. , Rogovsky Yu. A. , Ruban A. A. , Ryskulov N. M. , Ryzhenenkov A. E. , Semenov A. V. , Shatunov Yu. M. , Shatunov P. Yu. , Shebalin V. E. , Shemyakin D. N. , Shwartz B. A. , Shwartz D. B. , Sibidanov A. L. , Titov V. M. , Talyshev A. A. , Vorobiov A. I. , Zemlyansky I. M. , Yudin Yu. V.
Published: June 2019

A study of hadron production at the nucleon-antinucleon threshold has been performed with the CMD-3 detector at the VEPP-2000 e+e− collider. A very fast rise with an about 1 MeV width has been observed in the e+e−→ pp̅ cross section. A sharp drop in the e+ e−→ 3(π+π−) cross section has been con?rmed and found to have a width of less than 2 MeV, in agreement with the observed fast rise of the e+e−→ pp̅ cross section. For the ?rst time a similar sharp drop is demonstrated in the e+e−→ K+ K−π+π− cross section. The behavior of the e+e−→ 3(π+ π−), K+ K−π+π− cross sections cannot be explained by an interference of any resonance amplitude with continuum, therefore this phenomenon cannot be due to a narrow near-threshold resonance. No such structure has been observed in the e+e−→ 2(π+π−) cross section.
Identification of the e+e−→ nn̅ events in CMD-3 detector
Authors: Amirkhanov A.N. , Fedotovich G.V. , Gribanov S.S. , Logashenko I.B. , Popov A.S. , Ryskulov N.M. , Ryzhenenkov A.E.
Published: June 2019

A large amount of data collected with the CMD-3 detector above the threshold of the nn̅pair allows to measure the cross section of the process e+e−→ nn̅and the neutron form factor with good accuracy. This task is complicated by a large number of background events and necessity of finding ways to suppress them. A technique of identification for e+e−→ nn̅events is described.
Tau decays into two mesons: an overview
Authors: Gonzàlez-Solís Sergi
Published: June 2019

We review the state-of-the-art theoretical analyses of tau decays into a pair of mesons and a neutrino. The participant vector and scalar form factors, f+ (s) and f0(s), are described in the frame of Chiral Perturbation Theory with resonances supplemented by dispersion relations, and the physical parameters of the intermediate resonances produced in the decay are extracted through the pole position of f+,0(s) in the complex plane. As a side result, we also determine the low-energy observables associated to the form factors. We hope our study to be of interest for present and future experimental analyses of these decays.
Tau mass measurement at BES-III
Authors: Achasov M.N. , Mo X.H. , Muchnoi N.Yu. , Nikolaev I.B. , Privalov S.A. , Zhang J.Y.
Published: June 2019

A scan of the threshold region of the process e+ e−→ τ+τ− with integrated luminosity about 140 pb−1 was performed with the BES-III detector at the BEPC-II collider in order to measure the τ-lepton mass. The beam energy was determined by the Compton backscattering method. To verify the measurement accuracy scans of the J/ψ and ψ′ resonances were performed.
Open charm studies at Belle
Authors: Zhukova Valentina
Published: June 2019

We present the new results of measurements of the exlusive cross sections of the e+ e− annihilation to charmed meson pairs as a function of √ ceneter-of-mass energy from the open charm threashold up to $ \sqrt s = {\rm{6 GeV}} $ using initial state radiation technique. The analysis is based on a data sample collected by the Belle detector with an integrated luminosity of 951 fb−1. The accuracy of the cross section measurement is increased by a factor of 2 in comparison with the first Belle study. We have performed the first angular analysis + −→ D*± D*∓ of the $ {e^{\rm{ + }}}{e^ - } \to {D^{* \pm }}{D^{* \mp }} $ process and decomposed this exclusive cross section into three components corresponding to the diﬀerent D* helicities.
Comparison of applicable adjustment procedures for very small batches
Authors: Duret Daniel , Sergent Alain
Published: June 2019

The objective of this study is to propose and compare three methods of production process control that are voluntarily simple to implement on a machine. A mathematical formulation of the “sequence” type is used to model each method. An experimental validation is then carried out on the principle of launching a pre-production consisting of five parts machined and measured consecutively. A graphical analysis makes it possible to compare the different methods proposed and makes it possible to show the interest of the Bayesian weighted adjustment method.
Early treatment of open diaphyseal tibia fracture with intramedullary nail versus external fixator in Tanzania: Cost effectiveness analysis using preliminary data from Muhimbili Orthopaedic Institute
Authors: Haonga Billy T. , Areu Mapuor M.M. , Challa Sravya T. , Liu Max B. , Elieza Edmund , Morshed Saam , Shearer David
Published: June 2019

Introduction: Open tibia fractures are some of the most common types of Orthopedics injuries in low- and middle-income countries (LMICs). In Tanzania, open tibia fractures are treated either conservatively by prolonged cast or surgically by external fixation (EF) or intramedullary nail (IMN) when available. The cost of treatment and amount of time patients spend away from work are major economic concerns with prolonged casting and EF. The goal of this study was to determine the cost effectiveness of IMN versus EF in the treatment of open diaphyseal tibia fractures at Muhimbili Orthopaedic Institute (Dar es Salaam, Tanzania).

Methods: This is a prospective randomized control study conducted of patients with a closeable AO/OTA 42 open diaphyseal tibia fracture. The patients underwent surgical fixation with either IMN or EF at Muhimbili Orthopaedic Institute (MOI), and were followed up at 2, 6, and 12 weeks postoperatively. A micro-costing method was used to estimate the fixed and variable costs of IMN and EF of the open diaphyseal tibial fracture.

Results: The mean total cost per patient was lower for the IMN group ($425.8 ± 38.4) compared to the EF group ($559.6 ± 70.5, p < 0.001), with savings of $133.80 per patient for the IMN group. The mean hospital stay was 2.72 ± 1.40 days for the IMN group and 2.44 ± 1.47 days for the EF group (p = 0.5). Quality-adjusted life years (QALYs) were 0.26 per patient for the IMN group and 0.24 in the EF group at 12 weeks (p = 0.8). Ninety-two percent of patients in the IMN group achieved fracture union versus 60% in the EF group at three months postoperatively (p = 0.03).

Conclusion: IM nailing of a closeable open diaphyseal tibial fracture is more cost effective than EF. In addition, IM nailing has better union rates at three months compared to EF.
Empfehlungen zur maximalen Zuckerzufuhr in
Deutschland
Authors: Wenzel Sabine
Published: June 2019

Die Deutsche Gesellschaft für Ernährung (DGE), die Deutsche
Adipositas-Gesellschaft (DAG) und die Deutsche Diabetes-Gesellschaft (DDG)
haben im Dezember 2018 gemeinsam ein Konsensuspapier mit einer Empfehlung
zur maximalen Zufuhr freier Zucker in Deutschland veröffentlicht: Weniger
als 10 % der Gesamtenergiezufuhr sollen es sein – bei 2000 kcal/Tag sind das
maximal 50 g freier Zucker.
Tierwohl im Supermarktregal
Authors: Fleischhauer Anja
Published: June 2019

Im letzten Jahr brachte Lidl einen Haltungskompass für Frischfleisch heraus.
Kurze Zeit später zog Netto mit seinem Haltungszeugnis nach, dann Kaufland;
es folgten Penny und schließlich Aldi. Jedes Handelsunternehmen warf sein
eigenes Symbol ins Rennen – bei weitgehend vergleichbaren Kriterien der
Tierhaltung. Seit dem 1. April diesen Jahres haben diese
Einzelhandelsunternehmen zusammen mit Rewe und Edeka ihre Labels
vereinheitlicht. Es gilt für verpacktes Fleisch der jeweiligen
Eigenmarken.
Fasten für Menschen mit Typ-1-Diabetes
(FaMeD1)
Authors: Berger Bettina , Stange Rainer , Baumann Andrea , Köblös Diana , Liebscher Daniela , Bley Martina , Michalsen Andreas , Martin David
Published: June 2019

Typ-1-Diabetes mellitus (T1DM) ist eine fortschreitende und herausfordernde
chronische Erkrankung, welche immer wieder neue emotionale Anpassungsleistungen
erfordert 1. Im folgenden Studienprotokoll
wird das geplante Vorgehen zur Überprüfung der Machbarkeit und Sicherheit einer
Buchinger-Fastenintervention bei Menschen mit Typ-1-Diabetes mellitus in
Hinblick auf diabetesbezogene Problembereiche und unerwünschte Ereignisse wie
Ketoazidosen und schwere Unterzuckerungen vorgestellt.