bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Model for Optimized Gas Allocation in Gas Lift Operation Using Metaheuristic Algorithms
Authors: Merzoug Ahmed , Chemmakh Abderraouf , Ouadi Habib , Laalam Aimen , Djezzar Sofiane , Boualam Aldjia , Mouedden Nadia , Rasouli Vamegh , Ibrahim Ezdeen
Published: October 2022

Gas lift is one of the most commonly used artificial lift method in oil-producing wells. However, the technique requires constant optimization of gas allocation to maximize profit. The Gas Lift Performance Curves (GLPC) are the main design element that is used for optimized injection. Several authors have proposed models to fit the GLPC. These curves are generated by modeling wells in a multiphase steady-state simulator. Once the model is built, a sensitivity analysis is run, and the curves are generated. In this work, The common workflow to generate GLPC was followed. Then, a new correlation for GLPC was suggested. The correlation outperforms all the models in the literature in terms of R-score and root mean square error. The correlation was then used to formulate a case study for four wells located in North Africa. First, the wells and PVT models were used to create a simulation. Once the simulation was calibrated, a sensitivity analysis of the gas lift injection rate was run. The new correlation was used to fit the GLPC. The optimization problem was mathematically formulated, and stochastic optimization techniques were used, noting Grey Wolf Optimization (GWO) Algorithm and Genetic Algorithm (GA) to obtain the global optimum of the distribution of a limited gas lift quantity. Both algorithms’ results were compared. GWO slightly outperformed GA. The advantages of GWO over GA were discussed, and the optimum gas allocation was obtained.
The effect of violence acceptability on dating violence: Focusing on the escalation of coercive control
Authors:   Korean Association of Public Safety and Criminal Justice, Kim Ka-Eun
Published: October 2022

This study aims to determine how perceived violence acceptability affects dating violence in an individual. As opposed to previous studies, this study reclassified dating violence into coercive control (behavioral control, emotional abuse) and physical dating violence (physical violence, sexual violence).
It was examined in particular how individuals' acceptability for violence progressively grew from behavioral control to emotional abuse, and ultimately to physical violence. This is the difference between this study and previous studies. A total of 2,000 unmarried men between the ages of 19 and 60 were surveyed for this study. The study used data from the ‘Dating Violence Survey 2015’ conducted by the Korean Institute of Criminology and Justice.
Here are the results of the analysis. First, in the structural model, the criteria for model fit are met, so the research model can be accepted. Second, all paths show a statistically significant effect based on the path analysis. Third, all research models confirmed direct effect, indirect effect, and total effect as a result of mediating effect verification. The relationship between violence acceptability and physical violence, however, was not directly affected. Behavioral control and emotional abuse were confirmed to be mediated by a full mediating effect. Finally, all specific indirect effects associated with mediation pathways were found to be significant.
Thus, the results of this study suggest the importance of coercive control in dating violence, as well as directions for further research.
Review of legal protection measures against security threats related to Metaverse
Authors:   Korean Association of Public Safety and Criminal Justice, Lee Junhyoung , Min Heungki
Published: October 2022

After the COVID-19 pandemic, the importance of the metaverse has been highlighted as the proportion of online virtual space has expanded dramatically. The metaverse market will grow even bigger in the future, and it is highly likely that it will merge with various industrial fields and become inseparable from our daily lives. This is the reason why it is required to respond to various security threats caused by the characteristics of the virtual world. As a result of the review of previous studies, we selected personal information infringement and digital sex crimes as representative security threats related to Metaverse, and then reviewed legal protection measures against these two security threats.
To this end, the 「Personal Information Protection Act」 and 「Criminal Act」, the 「Act on Special Cases concerning the Punishment of Sexual Violence Crimes, etc.」, and the 「Act on the Protection of Children and Juveniles Sexuality」 were reviewed, and the 'Act on Special Cases concerning the Punishment of Sexual Violence Crimes, etc.' and 'Information We reviewed some amendments to the Act on Promotion of Communication Network Utilization and Information Protection, etc.
As a result of the review, rather than rushing to enact an independent law to deal with only the security threats related to the Metaverse, in order to ensure the healthy and safe use of the Metaverse, the legal system on various security threats related to the use of the Metaverse within the framework of the current law was revised. It is considered reasonable to amend or supplement or to enact a one-point law that applies to specific threats. Excessive sanctions against the rapidly growing metaverse industry have plenty of room to shrink the industry itself. However, the damage may snowball by delaying the related security threats. Therefore, it is judged that it is necessary to discuss legislation at a level that is acceptable to both the industry and users. To this end, legislative bodies must collect and analyze opinions from relevant industries, users, and expert groups to reduce the damage that short-sighted legislation enacts.n to the analysis of the functions and manpower of Amtrak police.
Artificial Intelligence-Based Defense Project Research on security vulnerabilities and countermeasures
Authors:   Korean Association of Public Safety and Criminal Justice, Jung Ung-kyu , Kim Do-young
Published: October 2022

This study examines the current state of artificial intelligence in the 4th Industrial Revolution, which is currently undergoing global development, and examines the systems that the United States and the Republic of Korea are incorporating into defense projects. The research was conducted to look at the security vulnerabilities identified to date and to suggest ways to compensate for the security vulnerabilities that may arise in the future development process.
Because AI operates on the basis of superintelligence and hyper-connectivity, if a part is hacked, it can damage the entire system, and if the data built up is turned into misinformation by a hacker, the entire operating system can be crippled. The weapons systems of defense projects developed and operated for the purpose of war may have more serious consequences for society than AI-based equipment used by civilians.
In this regard, we would like to explore the vulnerable areas that need to be supplemented and explore solutions based on the opinions of the literature and experts. We look forward to using it as a resource to help us now and in the future of leveraging artificial intelligence.
A Study on the Korean Electronic Evidence Disclosure (E-Discovery) Issue and Solutions
Authors:   Korean Association of Public Safety and Criminal Justice, Kim Bum-sun , Lee Sang-jin
Published: October 2022

These days, when core evidence of litigation is digitally produced and processed and especially important information is encrypted and preserved, the electronic evidence initiation model of countries that have already introduced the electronic evidence initiation system is supplemented or revised to suit each country's situation through trial. In the current domestic litigation environment where the electronic evidence disclosure system has not been established, it is difficult for litigants to secure digital evidence held by individuals, companies, and governments in litigation procedures. On the other hand, many countries, including the Anglo-American region, are already operating the e-Discovery system. Recently, discussions have been taking shape in Korea, such as the introduction of a Korean-style e-Discovery law, but concerns have also been raised about possible side effects. In particular, companies are concerned that confidential information of the company may be leaked to competitors through specialized companies or related persons in charge of investigation through the electronic evidence disclosure procedure. To solve this problem, this study aims to present the issues and improvements of the introduction of Korean electronic discovery through the ① qualification management of court-designated experts ② unilateral rejection of sensitive confidential information ③ public cloud server operation model ④ electronic evidence initiation council.
An Investigation of Weaning from Ventilator Criteria in Iran: A Systematic Review
Authors: Vafaee Kamran , Fallahi Masoud , Chale Maryam Chale , Hemmati Mahvan , Darvishi Niloufar
Published: October 2022

Background: Long-term mechanical ventilation can adversely affect patients and the healthcare system. Ventilator-dependent patients need specialized care, frequent monitoring, and long-term hospitalization in ICUs, increasing patient costs and intensive care units' occupation. 40% of the total time when the patient is connected to the mechanical ventilation device is devoted to the weaning process of these patients from the mechanical ventilation device. Therefore, it is necessary to separate the patient undergoing mechanical ventilation as soon as possible. Consequently, we conducted a systematic review study to investigate the best methods of weaning intensive care unit patients from the ventilator in Iran.
Method: In this systematic review, studies relevant to the latest methods according to PRISMA 2020 of weaning the patient from the ventilator in Iran, after transferring the studies to EndNote software and removing duplicate studies, were examined by two researchers separately. In case of disagreements, a third collaborator reassessed the study and made the final decision. The evaluation of the studies was done during the primary, secondary, qualitative evaluation, and data extraction stages.
Results: In the primary search in the researchers' chosen databases, we identified 1103 possible related articles and transferred them to EndNote software used for data management. We excluded 235 duplicate articles from our survey. In the screening stage, 457 articles were excluded from the remaining 868 studies by reading the article's title and its abstract according to inclusion and exclusion criteria. In the stage of evaluating the eligibility, from 411 studies, researchers excluded 402 articles by researchers through reading the full text of articles based on the inclusion and exclusion criteria due to their irrelevance. Based on STROBE and CONSORT checklists, the qualitative evaluation stage excluded no article from the remaining 9 studies due to poor methodological quality. Finally, nine studies were included in the final analysis.
Conclusion: Identifying and adopting strategies to promote successful mechanical ventilation weaning is a priority for research and quality improvement. This study has reviewed the evidence related to various methods designed to promote the success of weaning from the ventilator in Iran. However, it seems that more studies are needed to discover the effectiveness of ventilator-weaning strategies.
Mitigation of Cr (VI) from aqueous solution using jute charcoal iron composite (JC-FeCs): Response surface methodology (RSM)
Authors: kumari binu , Tiwary Rajani kant , yadav Mahendra
Published: October 2022

In this study potential adsorbent jute charcoal iron composite (JC-FeCs) was synthesized via co precipitation of iron composite on jute charcoal and utilized it for Cr (VI) removal from water. The surface morphology of composite were performed with advance techniques such as BET, FESEM, EDX, FTIR, XPS, AFM and HR-TEM to analyzed the surface functional groups and elements on the prepared composite. The influence of pH, JC-FeCs dose, time, and concentration on % removal of Cr (VI) were examined. Noteworthy, the JC-FeCs reveals excellent removal capacity of Cr (VI) (Qmax 92.33 mg/g) at 303K which is much better than those adsorbent reported in the literature. XPS analysis of adsorbent shows the existence of both Cr (VI) and Cr (III) peaks on JC-FeCs surface, which implied that Cr (VI) adsorption occurs on composite. Herein Cr (VI) was first adsorbed on JC-FeCs via electrostatic force of attraction, later it was partially reduced to Cr (III). Non-linear isotherm study suggests monolayer adsorption occurs on homogenous surface of JC-FeCs adsorbent due to greater value of R2 than other isotherm. Kinetic studies suggest that adsorption followed pseudo second order model with greater R2 value. Thermodynamic study indicate endothermic, spontaneous and physisorption adsorption process. The predicted result of Cr (VI) removal obtains from RSM model and the observed % removal were found close to each other indicate that quadratic model best explain the adsorption process. Desorption study shows the good regeneration ability of adsorbent in alkaline medium. Thus, this bio-composite could work as an effective adsorbent for mitigation of Cr (VI) from water in environmental pollution cleanup.
Umbilical Cord Blood CK-MB, Troponin T, ProBNP, IMA Levels, and Fetal Cardiac Function in Cases of IUGR
Authors: TURGUT Ezgi , Özdemir Halis , Narlı Belkıs , Yılmaz Canan , BAYRAM Merih , KARÇAALTINCABA Deniz
Published: October 2022

Objective: To evaluate umbilical cord blood creatine kinase MB (CK-MB), Troponin T (TnT-hs), pro-brain natriuretic peptide (proBNP), ischemia modified albumin (IMA) levels and fetal cardiac function in intrauterine growth retardation (IUGR).
Methods: The study included 39 pregnant women with IUGR and 42 healthy pregnant women in control group. IUGR was diagnosed when estimated fetal weight was <10 percentile. Fetal cardiac function was evaluated by ultrasound in third trimester of pregnancy and compared with control group. Umbilical cord blood biochemical test (CK-MB, TnT-hs, proBNP, IMA) results compared between the groups.
Results: In cardiac morphological evaluation, cardiothoracic index was higher and left sphericity index was lower in the IUGR group compared to the control group (p<0,001, p=0,018). Left myocardial performance index (MPI) was higher, tricuspid and mitral annular plane systolic excursion (TAPSE and MAPSE) values were lower in IUGR group than control group (p=0,035, p=0,038 and p=0,011 respectively). In IUGR group only proBNP levels was increased compare to control group in umbilical cord blood biochemical tests (p=0,018). There was negative correalation between umbilical cord blood proBNP levels and MAPSE value (r=-0,332, p=0,002).
Conclusions: We observed that IUGR was associated with fetal cardiac morphological changes and systolic dysfunction. Also, in IUGR group cord blood proBNP level was increased and negatively correlated with MAPSE value.
Identifying Molecular Markers for Resistance to Septoria tritici Blotch in Bread Wheat
Authors: Cobertera David , Mundt Christopher C. , Zemetra Robert
Published: October 2022

Septoria tritici blotch (STB) is a foliar disease of wheat (Triticum aestivum L.) caused by the ascomycete fungus Zymoseptoria tritici. STB is a polycyclic disease and represents a significant threat to wheat production, reducing yield and grain quality. The control of STB is mainly based on fungicides. Unfortunately, Z. tritici populations have evolved high resistance levels to some of these fungicides, causing them to lose their efficacy. Therefore, increasing STB resistance through plant breeding is the most cost-effective and environmentally friendly method for control. A recombinant inbred line (RIL) population was developed from a cross between a cultivar moderately susceptible to STB, ‘Madsen’ (PI 511673), and ‘Foote’ (PI 599663), which has provided moderate resistance to STB in the Pacific Northwest (PNW) region of the U.S. The RIL population, consisting of 217 lines, was phenotyped across multiple environments for STB response and genotyped using Illumina HiSeq 3000 Sequencing. The STACKS program was used to select SNPs. The best linear unbiased prediction (BLUP) value for each accession across different environments for STB severity was used for QTL mapping. Results of quantitative trait loci (QTL) analysis indicated minor genes associated with resistance in chromosomes 4B, 5A, 6B, 6D, and 7DS. Presence of all seven QTL in RILs reduced STB severity by over 70% compared to RILs lacking any of the QTL. These QTL could be used develop breeder-friendly molecular markers for genotypic selection of improved STB resistance in wheat in the PNW.
Knowledge, Practice, and factors associated with neonatal pain management among nurses working at West Oromia Public Hospitals, Ethiopia: A cross-sectional study
Authors: Mekonen Wandimu Muche , Muhye Addis Bilal , Gobeza Mengistu Berhanu
Published: October 2022

Introduction:
Pain is an unpleasant sensory and emotional experience associated with actual or potential damage. Recently, in developing countries including Ethiopia, there is insufficient data regarding the knowledge and practice of neonatal pain management among nurses. Hence, the current study identified the nurses’ knowledge, practice, and factors associated with neonatal pain management at west Oromia public hospitals.
Objective
This study aimed to assess knowledge, practice, and factors associated with neonatal pain management among nurses at west Oromia public hospitals, Ethiopia 2022.
Methods
An Institutional-based cross-sectional study design was used to conduct the study from all thirty-five public hospitals in west Oromia, from May 1 to 30/2022. A simple random sampling technique was used to select the study participant. The data was entered into Epi-data version 4.6 and exported to SPSS version 26 for analysis. Descriptive statistic was presented in text, tables, and charts. Bivariable and multivariable logistic regression was computed considering the p-value < 0.05 to identify statistically significant factors.
Result
This study was conducted with 203 staff nurses’ working in the neonatal intensive care unit with a response rate of 98.5%. 127(62.6%) of the nurses had adequate knowledge regarding neonatal pain management. As a practice, 33(16.3%) of the participant had a good practice. There was a significant association between nurses’ knowledge status and getting training on neonatal pain management at university/college (AOR, 2.31; CI 1.29, 4.27). The knowledge level (AOR, 3.3 CI: 1.14, 9.32), having a pain management policy in place (AOR, 5.44, CI: 1.92, 15.37), and receiving training on neonatal pain management at university/college (AOR, 2.55 CI: 1.09, 5.97) were significantly associated with the practice of nurses.
Conclusion and Recommendation:
The finding revealed that nurses had inadequate knowledge and practice in neonatal pain management. Though the level of nurses’ knowledge of neonatal pain management is mediocre and the level of nurses’ practice in neonatal pain management is unpredictably low. Therefore, providing training on neonatal pain management at university/college, providing on-job training, and endorsing pain management policy have a paramount role in improving nurses’ knowledge and practice on neonatal pain management.
Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease
Authors: Wilson Jennifer , Bowen Ellen , DiGiacomo Philip , Fraser Hannah , Guttenplan Kevin , Smith Benjamin , Heberling Marlene , Vidano Laura , Shamloo Mehrdad , Shah Nigam , Grimes Kevin
Published: October 2022

Schizophrenia is a debilitating condition necessitating more efficacious therapies. Previous studies suggested that schizophrenia development is associated with aberrant synaptic pruning by glial cells. We pursued an interdisciplinary approach to understand whether therapeutic reduction in glial cell – specifically astrocytic – phagocytosis might benefit neuropsychiatric patients. We discovered that beta-2 adrenergic receptor (ADRB2) agonists reduced phagocytosis using a high-throughput, phenotypic screen of over 3,200 compounds in primary human fetal astrocytes. We used protein interaction pathways analysis to associate ADRB2, to schizophrenia and endocytosis. We demonstrated that patients with a pediatric exposure to salmeterol, an ADRB2 agonist, had reduced in-patient psychiatry visits using a novel observational study in the electronic health record. We used a mouse model of inflammatory neurodegenerative disease and measured changes in proteins associated with endocytosis and vesicle-mediated transport after ADRB2 agonism. These results provide substantial rationale for clinical consideration of ADRB2 agonists as possible therapies for patients with schizophrenia.
Comprehensive analysis of the prognostic role and mutational characteristics of m6A-related genes in lung adenocacinoma
Authors: Chen Jing-Hua , Chu Xiang-Peng , Chen Zi-Hao , Chen Bi-Jun , Jiang Shao-Kun , Rosell Rafael , Zhong Wen-Zhao
Published: October 2022

Background
Lung adenocarcinoma (LUAD) is an invasive disease, which originates from small airway epithelial cells or alveolar type II cells. N6-methyladenosine (M6A) RNA methylation is involved in diverse biological processes. Studies have shown that m6A RNA methylation abnormalities play an important role in the pathogenesis of many human diseases, including cancer. The present study explores the prognostic role and mutational characteristics of m6A-related genes in LUAD.
Methods
RNA-seq and somatic mutation data of Genomic Data Commons and The Cancer Genome Atlas (GDC TCGA)-LUAD were downloaded from UCSC Xena for comprehensive analysis. M6A-related genes were selected from the content of RNA m6A modification in cancer. M6A genes were further screened by comparing the significance and survival of m6A genes between the normal group and the tumor group and analyzing the relationship between m6A genes and LUAD patients.
Results
GDC LUAD data were downloaded from UCSC Xena public database, and the gene expression data of 19 m6A methylation regulators in LUAD were extracted for differential expression levels. Then, the mutation of m6A genes was analyzed based on the single nucleotide polymorphism data of UCSC Xena. To further confirm the prognostic genes, univariate Cox regression and the Kaplan Meier method were used to determine the relationship between their expression level and the overall survival time in the TCGA database. Finally, HNRNPC, IGF2BP1, and IGF2BP3 genes were established for subsequent analysis. Correlation analyses showed that the three genes were correlated with clinical features and immune cell infiltration. Enrichment analysis revealed that HNRNPC was mainly enriched in ribonucleoprotein complex biogenesis, IGF2BP1 in the mitotic cell cycle checkpoint, and IGF2BP3 in the nuclear division pathway.
Conclusions
Our study identified novel immune-related prognostic markers of LUAD. Moreover, the potential mechanisms of prognostic markers in regulating the etiology of LUAD were investigated. These findings enrich our understanding of the relationships between immune and LUAD and may provide new insights into the treatment of LUAD patients.
Greening the financial regulation:Case of credit limit optimization for renewable energy
Authors: HIMRI Hicham , SAHNOUN Kacem , BAZZI Mehdi , Alaoui AbdelKader Ouatik El
Published: October 2022

The sense of urgency surrounding climate change is increasing over time, pushing the banking system to effectively align sustainable financial rules and project financing with the Paris Agreement’s Goals. Central banking lies on a set of instruments that address financial market functioning and financial stability at both the micro- and macroprudential levels. These instruments range from awareness to regulation and supervision. Our contribution consists in implementing one of these instruments, namely, credit limits, by employing mathematical modeling to optimize fund allocation in favor of the renewable energy sector, which is regarded as one of the least polluting. Our numerical application for a simulated bank portfolio has assisted in channeling a higher proportion of loans into renewable energy at the expense of other sectors that pose a high financial and environmental risk. Our findings have policy implications for both investors and policymakers.
Inter-pregnancy Interval Following Missed Abortion and the Risk for Preterm Birth
Authors: Bachar Gal , Abboud Yousef , Farago Naama , Justman Naphtali , Khatib Nizar , Zipori Yaniv , Weiner Zeev , Vitner Dana
Published: October 2022

Propose: Short inter-pregnancy interval (IPI), less than 18 months following live birth, has been associated with adverse pregnancy outcome. Our objective was to evaluate whether a short IPI following a medically treated missed abortion (MA) poses similar perinatal risks in a subsequent pregnancy.
Study Design: We performed a retrospective cohort study on women with MA, treated with Misoprostol (prostaglandin E1), and with a documented subsequent live pregnancy, at a single tertiary medical center (2010-2022). We excluded women who had surgical evacuation following failure of medical treatment. Women were allocated into two groups: IPI ≤ 18 months and IPI > 18 months. The primary outcome was the risk for a spontaneous preterm birth before 37 weeks of gestation in the consecutive pregnancy. Secondary outcomes included additional maternal and neonatal adverse outcome.
Results: We included 1,110 pregnancies: 430 (38.74%) women with IPI < 18 months and 680 (61.26%) women with IPI > 18 months. The characteristics of the two groups were not significantly different (Table 1), including Misoprostol number of doses.
The rate of spontaneous preterm birth < 37 and < 34 weeks’ gestation were significantly higher among women with a shorter IPI (16.28% vs. 7.06% and 6.74% vs. 5.0%, respectively, p<0.05). These women also had a higher risk for cesarean delivery (31.63% vs. 23.34%, p=0.005) and postpartum hemorrhage (PPH) (4.42% vs. 2.06%, p=0.029) compared to women with IPI > 18 months. No other significant differences were noted.
Conclusion: Short IPI (≤ 18 months) following a medical treatment for MA is associated with an increased risk of preterm birth, cesarean delivery, and PPH. Our findings may be particularly important for counseling women following missed abortion who desire another pregnancy.
Neurobehavioral and neurochemical basis of compulsive behavior: A 7T magnetic resonance spectroscopy study in humans
Authors: Biria Marjan , Banca Paula , Healy Mairead , Keser Engin , Sawiak Stephen , de Souza Ana Maria Frota Lisbôa Pereira , Marzuki Aleya , Sule Akeem , Ersche Karen , Robbins Trevor
Published: October 2022

There has been relatively little analysis of possible neurochemical correlates of compulsive behavior to illuminate its underlying neural mechanisms. We utilised 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and GABA levels in anterior cingulate cortex and supplementary motor area (SMA) of healthy volunteers and patients with Obsessive-Compulsive Disorder (OCD). Within the SMA, trait and clinical measures of compulsive behavior were related to glutamate levels, whereas a behavioral index of habitual control correlated with the glutamate:GABA ratio. OCD patients additionally exhibited elevated glutamate levels and glutamate:GABA ratios in anterior cingulate cortex which also correlated with habitual control. This study highlights important underlying relationships between SMA mechanisms of habitual control relevant to compulsive behavior, common to the healthy sub-clinical and OCD populations. The results also demonstrate additional involvement of anterior cingulate in the balance between goal-directed and habitual responding in OCD.
Management Of Foreign Bodies In The Gastrointestinal Tract: A Retrospective Study Of 24 Cases
Authors: Guo Zhuang , Zhang Taotao , Xue Jiaming , Yang Huiliang , Zhang Xiangwen
Published: October 2022

Background: Foreign body ingestion is frequently encountered in clinical practice. However, few studies have focused on gastrointestinal foreign body ingestion. This study aims to analyze the location of gastrointestinal foreign body ingestion and treatment measures to report our experience in its management.
Methods: Data were collected from all patients with foreign body ingestion accepting management in our center from September 2016 to July 2022. The demographic data, type, location, clinical features, and management were reviewed and analyzed retrospectively.
Results: A total of 24 cases with foreign body ingestion underwent management. Jujube pit ingestion was the most common (16 cases). Most of the ingested foreign bodies were located in the intestine (21 cases), especially in the small intestine (7 cases). One case in the duodenum and one in the rectum underwent conservative management, 3 cases in the stomach and 2 cases in the intestine underwent endoscopic treatment, and 17 cases in the intestine underwent surgical intervention.
Conclusions: Ingested foreign body is usually secondary to unconscious accidental ingestion and is frequently caused by dietary habits. Foreign body ingestion in the GI tract usually happens in the small intestine with perforation-peritonitis. Once foreign body ingestion is diagnosed, it must be decided on therapeutic regimens based on the location of foreign body.
Effects of morality and reputation on risk-taking behaviors on behalf of robots
Authors: Chen Na , Zhai Yanan , Liu Xiaoyu , Hu Xueyan
Published: October 2022

The relationship between robots and humans is becoming increasingly intimate and will continue to become an integral part of life, with robots working together with human beings. In teamwork, individual decision making for others is influenced by morality and reputation. However, the effect of individuals’ decision making for others in human-robot collaborative teams remains unclear, and individuals may have different degrees of consideration for morality and reputation when making decisions for robots or humans. This research conducted three experiments based on Gneezy and Potters' investment decision-making experimental paradigm and compared the influence mechanisms of morality and reputation on decision making for others in human teams and human-robot teams. Experiment 1 verifies that when the individual decision-making objects were robots and human beings, the decision making for others was different, When the decision object is a robot, the risk preference of the decision making for others’ behavior is higher .Experiment 2 verifies that morality and reputation are the influencing factors of the differences in the decision making for others. Experiment 3 proposes the mechanism of the difference between the decision making for others in a human team and a human-robot team. That is, in a human-robot team, reputation is a mediating variable of the influence of morality on the decision making for others, while in a human team, there is no such mediating effect. The research results show that people's decision making for others is influenced by their cooperation partner. When the cooperation partner is a robot, the risk preference of the decision making for others is higher because of the low constraint of social morality. However, if a good reputation is maintained for morality considerations, then the risk preference of the decision making for others will be reduced.
Effects of environmental exposures on the barely visible impact damage of flax fibre reinforced biocomposite and its glass fibre hybrids
Authors: Ahamed Muneer Ahmed Musthaq Musthaq , Dhakal Hom Nath , Zhang Zhongyi , Barouni Antigoni , Lupton Colin , Zahari Rizal Bin , Shibli Abdullah Al , Babaa Saleh Elkelani , Jiang Chulin
Published: October 2022

Exposure of biocomposites to various environmental conditions is a concern when used for structural and semi-structural outdoor applications. This study investigates the effect of different environmental exposures on the low-velocity impact damage behaviour of flax fibre reinforced epoxy composite and its glass/flax hybrids. Flax and flax/glass hybridised epoxy laminates were fabricated using the vacuum infusion technique. A drop-weight low-velocity impact tests were performed on composite laminates at 5 J of incident energy with sub-zero temperatures, i.e., at (-10°C and − 20°C) and room temperature (R.T.). In order to evaluate the induced damage at different temperatures, micro-computed tomography (µ-CT) and visual inspection techniques were employed. The experimental results show that at a sub-zero temperature of -20°C, the flax and hybrid glass/flax composites showed more brittle damage behaviour than at room temperature. Furthermore, these experimental results have shown that alternating hybrid glass/flax laminates exhibited noticeable transverse cracks at R.T. and − 10°C., with higher absorbed energy and maximum impact load-carrying ability arising from positive hybrid effects. Also, it is evidenced from the results that the hybrid approach can be a viable strategy for achieving improved impact performance of natural plant fibre reinforced composites (NPFRCs) when exposed to different environmental conditions.
Size effect in PbS Quantum Dots Luminescence
Authors: Grevtseva Irina , Chevychelova Tamara , Ovchinnikov Oleg , Smirnov Mikhail , Kondratenko Tamara , Khokhlov Vladimir , Zvyagin Andrey , Astashkina Marina
Published: October 2022

This paper presents new regularities of the size effect in IR luminescence of semiconductor colloidal PbS quantum dots, passivated with thioglycolic acid molecules (PbS/TGA QDs). It was found that decrease in the average PbS/TGA QDs size of the sample from 4.9 nm to 2.6 nm produces the luminescence peak shifts from 1350 nm to 865 nm. At that time, in the excitation spectrum the peak due to exciton absorption shifts from 1235 nm to 707 nm. The Stokes shift increases from 0.086 to 0.32 eV. The study of time-resolved luminescence showed that the luminescence decay is complex non-exponential it, that is determined by the statistical distribution of luminescence quenchers in PbS/TGA QDs over the ensemble. The complex of the obtained experimental results made it possible to conclude that the observed luminescence is determined by the radiative annihilation of exciton in PbS/TGA QDs.
Characterization and genome analysis of the novel phage VS1 infecting the pathogenic bacterium Vibrio splendidus of Apostichopus japonicus
Authors: Duan Xuemei , Jiang Liming , Guo Ming , Li Chenghua
Published: October 2022

Vibrio splendidus is one of the common pathogens in the ocean and infects Apostichopus japonicus, Atlantic salmon and Crassostrea gigas, leading to a variety of diseases. In this study, a virulent phage, VS1, which infects V. splendidus, was isolated from aquaculture ponds in Dalian, China. Its genome annotation and characterization were detected. The complete genome of phage VS1 consists of a linear double-stranded DNA that is 248,270 bp in length with an average G + C content of 42.5% and 144 putative protein-coding genes, and 116 genes have known functions. There are 4 tail fiber genes in the positive and negative strands of the phage VS1 genome. The domains and crystal structure of the phage VS1 tail fibers were obtained from the Protein Data Bank and SMART (http://smart.embl.de) database. The bacteriostatic effect of phage VS1 on V. splendidus culture was 93.5 times. Comparative genomic and phylogenetic analyses indicate that phage VS1 is a novel phage. This study provides the genome characterization of the novel phage VS1 that infects V. splendidus.
Characterization and establishment of an immortalized rabbit ovary granulosa cell line for reproductive biology experiments
Authors: Bao Zhiyuan , Chen Yang , Li Jiali , Zhang Xiyu , Dai Yingying , Wang Fan , Cai Jiawei , Ren Yuyao , Zhao Bohao , Wu Xinsheng
Published: October 2022

Granulosa cells (GCs) are the key components of ovarian follicles for regulating oocyte maturation. communicating with oocytes through complex gap junctions and regulate the growth and development of oocytes. In addition to being considered to have great potential for human therapeutic model development and livestock breeding. Here, we transformed lentivirus-mediated simian virus 40 Large T (SV40LT) into primary rabbit granulosa cells (Pri RGCs) to establish an immortalized cell line. Morphologically, the immortalized RGCs (Im RGCs) were indistinguishable from the Pri RGCs, cell structure was intact following H&E staining. No significant difference in cell proliferation viability and growth between Im RGCs and Pri RGCs. Based on GCs-specific markers, the expression of FSHR, StAR, CYP11A1 and CYP17A1 were identified by PCR, immunofluorescence, and western blot analysis. ELISA shows that ImRGCs can synthesize steroid hormones normally. Karyotype analysis showed that the number of chromosomes remained normal during the process of infinite passage, soft-agar cloning experiment and nude mice tumorigenic experiment Indicates that the ImRGCs were not malignantly transformed. In conclusion, the immortalized granulosa cell line of rabbit follicle was established and can be used as a tool cell for future studies on biological research, animal husbandry and female reproductive disease.
Small Protein NBASP Encoded by lncRNA FAM201A Decreases Neuroblastoma Progression via FABP5
Authors: Ye Mujie , Gao Runnan , Chen Shiyu , Bai Jianan , Chen Jinhao , Lu Feiyu , Gu Danyang , Shi Xiaoting , Yu Ping , Tang Qiyun , Dong Kuiran
Published: October 2022

Increasing evidence indicates that long non-coding RNA (lncRNA) is one of the most important RNA regulators in the pathogenesis of neuroblastoma (NB). However, limited studies have addressed the possibility that lncRNAs possess the ability of encoding functional peptides, which could affect the initiation and development of tumors by participating in signal pathway transduction, immune regulation, and tumor
metabolism. Here, we found that downregulation of lncRNA FAM201A was associated with NB malignant progression and a poor prognosis. A variety of gain- and loss-of-function studies elucidated the anti-tumor effects of lncFAM201A on the
regulation of growth and metastasis of NB cells. Surprisingly, combined with database predictions and experimental verifications, we found that significantly down-regulating lncRNA FAM201A in NB identified the ability to encode the
tumor-suppressing micropeptide, NBASP, which negatively regulated the expression of FABP5. Mechanistically, our transcriptomics analyses confirmed that the regulatory role between NBASP and FABP5 was mediated by activation of the ERK
pathway. In conclusion, our findings revealed that NBASP encoded by lncRNA FAM201A played a tumor-suppressor role in NB carcinogenesis via down-regulating FABP5 to inactivate the ERK pathway. These results extended our understanding of the relationship of lncRNA-encoded functional peptides and plasticity of tumor progression.
Necessity of pathological examination of reflux esophagitis
Authors: Chen Qianqian , Linghu Enqiang , Zhu Wenya , Niu Shaoli , Li Yi , Li Jia
Published: October 2022

Background: Routine biopsies are not recommended in the guidelines for RE patients, whereas upper gastrointestinal endoscopy combined with histopathological examination is necessary for RE patients with high-risk factors.
Methods: The medical records of 613 patients with RE who had undergone upper gastrointestinal endoscopy and biopsy for histopathological examination were collected. Relevant and risk factors for pathological outcomes were analyzed.
Result: The proportions of middle-aged and male participants were higher. The pathological outcome was related to age and endoscopic findings, but not sex. Age is a risk factor for intestinal metaplasia and is associated with esophagitis severity. Esophageal mucosa status, white moss, and hemostasis with adrenaline are relevant with LIN,only mucosal status is a risk factor. LA Grade is a significant risk factor for HIN. Mucosa status and white moss are both risk factors for erosive ulcer and pathological follow-up necessity.
Conclusion: Biopsy and pathological follow-up of cases with risk factors, especially endoscopic mucosal abnormalities, help screen for precancerous lesions and reduce misdiagnosis.
Application of feed-forward neural network approaches to ApplicationApplication of feed-forward neural network approaches to radiomics-based survival analysis in glioma patients radiomics-based survival analysis in glioma patients
Authors: Remigio Adrian Sabariaga , Franich Rick , Panettieri Vanessa
Published: October 2022

Radiomic features extracted from MR images, along with other clinical covariates, have been shown to facilitate glioma patient prognostication via survival analysis. In this study, we apply the DeepSurv and neural network-parameterized probability mass function (PMF-NN) models to the survival analysis of glioma patients using the age and extracted radiomic features from multiparametric MRIs in the Brain Tumor Segmentation Challenge 2018 (BraTS 2018) dataset. First order and texture features were calculated for the whole tumor and peritumoral brain zone (PBZ) regions in both T1-weighted contrast-enhanced (T1-wce) and T2-weighted fluid attenuated inversion recovery (T2-FLAIR) images. To the best of our knowledge, this work is the first to apply the DeepSurv and PMF-NN models to radiomics-based survival analysis of glioma patients. Whole tumor shape features were also calculated from the delineated masks of the whole tumor. Pearson correlation analysis showed age, 4 first-order, 10 shape, and 17 texture features are correlated with the overall survival of glioma patients. These correlated features were used as input for the developed DeepSurv and PMF-NN models. The best performing DeepSurv model in our study obtained a 1050-day integrated Brier score (IBS) and C-index of 0.122 and 0.670, respectively. For the best performing PMF-NN in terms of IBS, a 1050-day IBS of 0.125 and a C-index of 0.632 were obtained. Thus, our DeepSurv and PMF-NN models provide clinically informative predictions. Our developed models outperformed the Cox proportional hazards (CPH) with supervised principal component analysis (SPCA) from a separate study in terms of IBS.
[18F]-PSMA-1007-PET for evaluation of kidney function
Authors: Rassek Philipp , Schäfers Michael , Rahbar Kambiz , Backhaus Philipp
Published: October 2022

Purpose
Prostate-specific membrane antigen (PSMA) is present in the proximal tubule cells of the kidneys. This results in high renal tracer uptake in PSMA-PET, which may contain useful information on renal function. As part of the clinical evaluation for [177Lu]-PSMA therapies, patients undergo PSMA-PET and often additional [99mTc]-mercapto-acetyltriglycine (MAG3) scintigraphy to assess renal function. Aim of this study was to evaluate estimation of renal function with [18F]-PSMA-1007-PET/CT (PSMA-PET) by comparison to synchronous MAG3-scintigraphies.
Methods
We retrospectively investigated 73 prostate cancer patients with 93 synchronously available PSMA-PET/CT, MAG3-scintigraphies and serum creatinine. For determination of split renal function in PSMA-PET/CT, we evaluated the relative unilateral total renal PSMA uptake, i.e. SUVmean multiplied by the renal volume (SRFPSMA-TOTAL) and relative unilateral maximal standardized uptake value (SRFSUV). These were compared to MAG3 split renal function (SRFMAG3) using Pearson correlation and receiver operating characteristics analysis. For determination of global renal function, correlation of bilateral total renal PSMA uptake with MAG3 tubular excretion rate and serum creatinine was assessed.
Results
SRFMAG3 was strongly correlated with SRFPSMA-TOTAL (r= 0.872, p<0.001) and with SRFSUV (r=0.815, p<0.001). Relevant abnormalities of SRFMAG3 (unilateral renal function < 25 %) could be detected with sensitivities and specificities of 90% and 92% for SRFPSMA-TOTAL, and 80% and 95% for SRFSUV. Measures of absolute renal function were only weakly correlated with bilateral total renal PSMA uptake.
Conclusion
Renal [18F]-PSMA-1007 uptake allowed to quantify renal split function with good accuracy based on SRFPSMA-TOTAL or SRFSUV.
Ultrastructure morphology of antennae and mouthparts of in-vasive pest Aethina tumida (Coleoptera: Nitidulidae)
Authors: Chen Xiao-Xiao , Chen Rui-Ling , He Ding-Kun , Huang Min
Published: October 2022

The small hive beetle (SHB), as one of the six major pathogens of honeybee, has invaded China in recent years and caused serious harm to the apiculture industry of China. In order to explore the feeding mechanism ofAethina tumida, we used scanning electron microscopy for the first time to conduct a detailed study on the morphology and structure of antennae and mouthparts, including the distribution and abundance of sensilla. The results showed that its clavate antennae and chewing mouthparts are similar to those of other nitidulid on the structure and types of sensilla. There are 5 types of sensilla were identified on antennae: 3 subtypes of sensilla chaetica (SC), 1 type of sensilla trichodea (SP), 6 subtypes of sensilla basiconica (SB), 2 subtypes of sensilla styloconica (SS) and 1 type of Böhm bristles (BB); 8 types of sensilla on mourthparts: 1 type of SC, 8 subtypes of SB, 2 subtypes of SP, 2 subtypes of SS, 1 type of SM, 1 type of sensilla coelocinica (Sco), 2 subtypes of campaniformia (Scam) and 1 type of BB. We also compared the differences of sensilla with the only reported nitiduline speciesOmositacolonand inferred their sensory function.