bluuebunny/crossref_metadata_2025 huggingface dataset:
Stand-Alone Posterior Expandable Cage Technique for Adjacent Segment Degeneration with Lumbar Spinal Canal Stenosis: A Retrospective Case Series
Authors: Choi Woo-Jin , Kim Seung-Kook , Alaraj Manhal , Kim Hyeun-Sung , Lee Su-Chan
Published: March 2021

Background and Objectives: Symptomatic adjacent segment degeneration (ASD) with lumbar spinal canal stenosis (LSCS) is a common complication after spinal intervention, particularly interbody fusion. Stand-alone posterior expandable cages enable interbody fusion with preservation of the previous operation site, and screw-related complications are avoided. Thus, the aim of this study was to investigate the clinicoradiologic outcomes of stand-alone posterior expandable cages for ASD with LSCS. Materials and Methods: Patients with persistent neurologic symptoms and radiologically confirmed ASD with LSCS were evaluated between January 2011 and December 2016. The five-year follow-up data were used to evaluate the long-term outcomes. The radiologic parameters for sagittal balance, pain control (visual analogue scale), disability (Oswestry Disability Index), and early (peri-operative) and late (implant) complications were evaluated. Results: The data of 19 patients with stand-alone posterior expandable cages were evaluated. Local factors, such as intervertebral and foraminal heights, were significantly corrected (p < 0.01 and p < 0.01, respectively), and revision was not reported. The pain level (p < 0.01) and disability rate (p < 0.01) significantly improved, and the early complication rate was low (n = 2, 10.52%). However, lumbar lordosis (p = 0.62) and sagittal balance (p = 0.80) did not significantly improve. Furthermore, the rates of subsidence (n = 4, 21.05%) and retropulsion (n = 3, 15.79%) were high. Conclusions: A stand-alone expandable cage technique should only be considered for older adults and patients with previous extensive fusion. Although this technique is less invasive, improves the local radiologic factors, and yields favorable clinical outcomes with low revision rates, it does not improve the sagittal balance. For more widespread application, the strength of the cage material and high subsidence rates should be improved.
Mushroom-Derived Bioactive Molecules as Immunotherapeutic Agents: A Review
Authors: Patel Dinesh K. , Dutta Sayan Deb , Ganguly Keya , Cho Seong-Jun , Lim Ki-Taek
Published: March 2021

Mushrooms with enhanced medicinal properties focus on finding such compounds that could modulate the human body’s immune systems. Mushrooms have antimicrobial, antidiabetic, antiviral, hepatoprotective, antitumor, and immunomodulatory properties due to the presence of various bioactive components. β-glucans are the major constituent of the mushroom cell wall and play a significant role in their biological activity. This review described the techniques used in the extraction of the active ingredients from the mushroom. We highlighted the structure of the bioactive polysaccharides present in the mushrooms. Therapeutic applications of different mushrooms were also described. It is interesting to note that mushrooms have the potential sources of many bioactive products that can regulate immunity. Thus, the development of functional medicinal food based on the mushroom is vital for human welfare.
The Function of Selenium in Central Nervous System: Lessons from MsrB1 Knockout Mouse Models
Authors: Shi Tengrui , Song Jianxi , You Guanying , Yang Yujie , Liu Qiong , Li Nan
Published: March 2021

MsrB1 used to be named selenoprotein R, for it was first identified as a selenocysteine containing protein by searching for the selenocysteine insert sequence (SECIS) in the human genome. Later, it was found that MsrB1 is homologous to PilB in Neisseria gonorrhoeae, which is a methionine sulfoxide reductase (Msr), specifically reducing L-methionine sulfoxide (L-Met-O) in proteins. In humans and mice, four members constitute the Msr family, which are MsrA, MsrB1, MsrB2, and MsrB3. MsrA can reduce free or protein-containing L-Met-O (S), whereas MsrBs can only function on the L-Met-O (R) epimer in proteins. Though there are isomerases existent that could transfer L-Met-O (S) to L-Met-O (R) and vice-versa, the loss of Msr individually results in different phenotypes in mice models. These observations indicate that the function of one Msr cannot be totally complemented by another. Among the mammalian Msrs, MsrB1 is the only selenocysteine-containing protein, and we recently found that loss of MsrB1 perturbs the synaptic plasticity in mice, along with the astrogliosis in their brains. In this review, we summarized the effects resulting from Msr deficiency and the bioactivity of selenium in the central nervous system, especially those that we learned from the MsrB1 knockout mouse model. We hope it will be helpful in better understanding how the trace element selenium participates in the reduction of L-Met-O and becomes involved in neurobiology.
Highly Efficient Methylene Blue Dye Removal by Nickel Molybdate Nanosorbent
Authors: Rakass Souad , Oudghiri Hassani Hicham , Mohmoud Ahmed , Kooli Fethi , Abboudi Mostafa , Assirey Eman , Al Wadaani Fahd
Published: March 2021

Removing methylene blue (MB) dye from aqueous solutions was examined by the use of nickel molybdate (α-NiMoO4) as an adsorbent produced by an uncomplicated, rapid, and cost-effective method. Different results were produced by varying different parameters such as the pH, the adsorbent dose, the temperature, the contact time, and the initial dye concentration. Adsorbent dose and pH had a major removal effect on MB. Interestingly, a lower amount of adsorbent dose caused greater MB removal. The amount of removal gained was efficient and reached a 99% level with an initial methylene blue solution concentration of ≤160 ppm at pH 11. The kinetic studies indicated that the pseudo-second-order kinetic model relates very well with that of the obtained experimental results. The thermodynamic studies showed that removing the MB dye was favorable, spontaneous, and endothermic. Impressively, the highest quantity of removal amount of MB dye was 16,863 mg/g, as shown by the Langmuir model. The thermal regeneration tests revealed that the efficiency of removing MB (11,608 mg/g) was retained following three continuous rounds of recycled adsorbents. Adsorption of MB onto α-NiMoO4 nanoparticles and its regeneration were confirmed by Fourier transform infrared spectroscopy (FTIR) analysis and scanning electron microscopy (SEM) analysis. The results indicated that α-NiMoO4 nanosorbent is an outstanding and strong candidate that can be used for removing the maximum capacity of MB dye in wastewater.
Genetically Encodable Scaffolds for Optimizing Enzyme Function
Authors: Tan Yong Quan , Xue Bo , Yew Wen Shan
Published: March 2021

Enzyme engineering is an indispensable tool in the field of synthetic biology, where enzymes are challenged to carry out novel or improved functions. Achieving these goals sometimes goes beyond modifying the primary sequence of the enzyme itself. The use of protein or nucleic acid scaffolds to enhance enzyme properties has been reported for applications such as microbial production of chemicals, biosensor development and bioremediation. Key advantages of using these assemblies include optimizing reaction conditions, improving metabolic flux and increasing enzyme stability. This review summarizes recent trends in utilizing genetically encodable scaffolds, developed in line with synthetic biology methodologies, to complement the purposeful deployment of enzymes. Current molecular tools for constructing these synthetic enzyme-scaffold systems are also highlighted.
GC-FID-MS Based Metabolomics to Access Plum Brandy Quality
Authors: Ivanović Stefan , Simić Katarina , Tešević Vele , Vujisić Ljubodrag , Ljekočević Marko , Gođevac Dejan
Published: March 2021

Plum brandy (Slivovitz (en); Šljivovica(sr)) is an alcoholic beverage that is increasingly consumed all over the world. Its quality assessment has become of great importance. In our study, the main volatiles and aroma compounds of 108 non-aged plum brandies originating from three plum cultivars, and fermented using different conditions, were investigated. The chemical profiles obtained after two-step GC-FID-MS analysis were subjected to multivariate data analysis to reveal the peculiarity in different cultivars and fermentation process. Correlation of plum brandy chemical composition with its sensory characteristics obtained by expert commission was also performed. The utilization of PCA and OPLS-DA multivariate analysis methods on GC-FID-MS, enabled discrimination of brandy samples based on differences in plum varieties, pH of plum mash, and addition of selected yeast or enzymes during fermentation. The correlation of brandy GC-FID-MS profiles with their sensory properties was achieved by OPLS multivariate analysis. Proposed workflow confirmed the potential of GC-FID-MS in combination with multivariate data analysis that can be applied to assess the plum brandy quality.
Multivariate Statistical Approach for Nephrines in Women with Obesity
Authors: Robeva Ralitsa , Nedyalkova Miroslava , Kirilov Georgi , Elenkova Atanaska , Zacharieva Sabina , Kudłak Błażej , Jatkowska Natalia , Simeonov Vasil
Published: March 2021

Catecholamines are physiological regulators of carbohydrate and lipid metabolism during stress, but their chronic influence on metabolic changes in obese patients is still not clarified. The present study aimed to establish the associations between the catecholamine metabolites and metabolic syndrome (MS) components in obese women as well as to reveal the possible hidden subgroups of patients through hierarchical cluster analysis and principal component analysis. The 24-h urine excretion of metanephrine and normetanephrine was investigated in 150 obese women (54 non diabetic without MS, 70 non-diabetic with MS and 26 with type 2 diabetes). The interrelations between carbohydrate disturbances, metabolic syndrome components and stress response hormones were studied. Exploratory data analysis was used to determine different patterns of similarities among the patients. Normetanephrine concentrations were significantly increased in postmenopausal patients and in women with morbid obesity, type 2 diabetes, and hypertension but not with prediabetes. Both metanephrine and normetanephrine levels were positively associated with glucose concentrations one hour after glucose load irrespectively of the insulin levels. The exploratory data analysis showed different risk subgroups among the investigated obese women. The development of predictive tools that include not only traditional metabolic risk factors, but also markers of stress response systems might help for specific risk estimation in obesity patients.
Recoverable Palladium-Catalyzed Carbon-Carbon Bond Forming Reactions under Thermomorphic Mode: Stille and Suzuki-Miyaura Reactions
Authors: Tessema Eskedar , Elakkat Vijayanath , Chiu Chiao-Fan , Tsai Zong-Lin , Chan Ka Long , Shen Chia-Rui , Su Han-Chang , Lu Norman
Published: March 2021

The reaction of [PdCl2(CH3CN)2] and bis-4,4′-(RfCH2OCH2)-2,2′-bpy (1a–d), where Rf = n-C11F23 (a), n-C10F21 (b), n-C9F19 (c) and n-C8F17 (d), respectively, in the presence of dichloromethane (CH2Cl2) resulted in the synthesis of Pd complex, [PdCl2[4,4′-bis-(RfCH2OCH2)-2,2′-bpy] (2a–d). The Pd-catalyzed Stille arylations of vinyl tributyltin with aryl halides were selected to demonstrate the feasibility of recycling usage with 2a as the catalyst using NMP (N-methyl-2-pyrrolidone) as the solvent at 120–150 °C. Additionally, recycling and electronic effect studies of 2a–c were also carried out for Suzuki-Miyaura reaction of phenylboronic acid derivatives, 4-X-C6H4-B(OH)2, (X = H or Ph) with aryl halide, 4-Y-C6H4-Z, (Y = CN, H or OCH3; Z = I or Br) in dimethylformamide (DMF) at 135–150 °C. At the end of each cycle, the product mixtures were cooled to lower temperature (e.g., −10 °C), and then catalysts were recovered by decantation with Pd leaching less than 1%. The products were quantified by gas chromatography/mass spectrometry (GC/MS) analysis or by the isolated yield. The complex 2a-catalyzed Stille reaction of aryl iodides with vinyl tributyltin have good recycling results for a total of 8 times, with a high yield within short period of time (1–3 h). Similarly, 2a–c-catalyzed Suzuki-Miyaura reactions also have good recycling results. The electronic effect studies from substituents in both Stille and Suzuki-Miyaura coupling reactions showed that electron withdrawing groups speed up the reaction rate. To our knowledge, this is the first example of recoverable fluorous long-chained Pd-catalyzed Stille reactions under the thermomorphic mode.
Moringa oleifera Extract Extenuates Echis ocellatus Venom-Induced Toxicities, Histopathological Impairments and Inflammation via Enhancement of Nrf2 Expression in Rats
Authors: Adeyi Akindele O. , Adeyemi Sodiq O. , Effiong Enoh-Obong P. , Ajisebiola Babafemi S. , Adeyi Olubisi E. , James Adewale S.
Published: March 2021

Echis ocellatus snakebite causes more fatalities than all other African snake species combined. Moringa oleifera reportedly possesses an antivenom property. Therefore, we evaluated the effectiveness of M. oleifera ethanol extract (MOE) against E. ocellatus venom (EOV) toxicities. Thirty male rats were grouped as follows (n = 5): Group 1 (normal control received saline), groups 2 to 6 were administered intraperitoneally, 0.22 mg/kg (LD50) of EOV. Group 2 was left untreated while group 3 to 6 were treated post-envenoming with 0.2 mL of polyvalent antivenom, 200, 400, and 600 mg/kg of MOE respectively. MOE significantly (p < 0.05) normalized the altered haematological indices and blood electrolytes profiles. MOE attenuated venom-induced cellular dysfunctions, characterized by a significant increase in NRF2, and concomitant downregulation of increased antioxidant enzymes (SOD and CAT) activities in the serum and heart of the treated rats. MOE normalized the elevated TNF-α and IL-1β in serum and heart tissues. Furthermore, the IgG titre value was significantly (p < 0.5) higher in the envenomed untreated group compared to the MOE-treated groups. Hemorrhagic, hemolytic and coagulant activities of the venom were strongly inhibited by the MOE dose, dependently. Lesions noticed on tissues of vital organs of untreated rats were abolished by MOE. Our findings substantiate the effectiveness of MOE as a potential remedy against EOV toxicities.
Strengthening Regenerated Cellulose Fibers Sourced from Recycled Cotton T-Shirt Using Glucaric Acid for Antiplasticization
Authors: Biswas Manik Chandra , Dwyer Ryan , Jimenez Javier , Su Hsun-Cheng , Ford Ericka
Published: March 2021

The recycling of cellulose from cotton textiles would minimize the use of virgin crop fibers, but recycled polymers are generally inferior in mechanical performance to those made from virgin resins. This challenge prompted the investigation of biobased additives that were capable of improving the mechanical properties of fibers by means of antiplasticizing additives. In this study, regenerated cellulose (RC) fibers were spun from cellulose found in cotton T-shirts, and fibers were mechanically strengthened with glucaric acid (GA), a nontoxic product of fermentation. The recycled pulp was activated using aqueous sodium hydroxide and then followed by acid neutralization, prior to the direct dissolution in lithium chloride/N,N-dimethylacetamide (LiCl/DMAc) at 3 wt.% cellulose. At 10% (w/w) GA, the tensile modulus and strength of regenerated cellulose from recycled cotton fibers increased five-fold in contrast to neat fibers without GA. The highest modulus and tenacity values of 664 cN/dtex and of 9.7 cN/dtex were reported for RC fibers containing GA.
Biopolymer Matrices Based on Chitosan and Fibroin: A Review Focused on Methods for Studying Surface Properties
Authors: Zakharova Vasilina A. , Kildeeva Nataliya R.
Published: March 2021

For the creation of tissue-engineered structures based on natural biopolymers with the necessary chemical, physical, adhesive, morphological, and regenerative properties, biocompatible materials based on polysaccharides and proteins are used. This work is devoted to a problem of the technology of polymeric materials for biomedical purposes: the creation of biopolymer tissue engineering matrix and the development of a methodology for studying morphology and functional properties of their surface to establish the prospects for using the material for contact with living objects. The conditions for the formation of scaffolds based on composite materials of chitosan and fibroin determine the structure of the material, the thickness and orientation of molecular layers, the surface morphology, and other parameters that affect cell adhesion and growth. The analysis of studies of the morphology and properties of the surface of biopolymer matrices obtained using different methods of molding from solutions of chitosan and fibroin is carried out.
Identification and Validation of Operational Welfare Indicators Appropriate for Small-Scale Goat Farming in Chile
Authors: Rodriguez Jaqueline , Morales Mario , Cañon-Jones Hernan
Published: March 2021

Goat production in Chile is carried by small-scale farmers obtaining milk and cheese as the main products. The welfare of goats under these types of production systems is currently unknown and no appropriate validated operational welfare indicators are currently available. We took the tasks of identifying operational welfare indicators and validating them with all stakeholders. A total of 37 operational welfare indicators were obtained. The use of these validated indicators and the welfare score is appropriate to Chilean goat production systems and may successfully increase the sustainability of production and farmers in Chile.
A Methodological Approach for Assessing the Safety of Historic Buildings’ Façades
Authors: Ruggiero Giovanni , Marmo Rossella , Nicolella Maurizio
Published: March 2021

Inefficiency in maintaining and managing architectural heritage threatens both heritage conservation and public safety. Damage related to collapsed building elements requires an investigation into the factors which cause these phenomena in order to prevent them and to mitigate their effects. This paper aims to define a methodological approach for assessing the risk to humans of falling bodies from historic buildings’ façades. The method is based on the identification of a group of parameters to assess façade’s hazards, vulnerability and public exposure. The results provide the identification of risk factors and related affecting parameters, proposing a synthetic indicator to quantify the risk. The proposal is original in the field of both maintenance planning and preventive maintenance, intending to preserve architectural heritage and public safety. The results lead to an easy tool, as a map, to prioritise risk mitigation interventions. Such a tool, if integrated into maintenance tenders, allows the evaluation, in the context of condition-based maintenance, of the need for interventions.
Spontaneous Grafting of OH-Terminated Molecules on Si−H Surfaces via Si–O–C Covalent Bonding
Authors: Dief Essam M. , Brun Anton P. Le , Ciampi Simone , Darwish Nadim
Published: March 2021

The surface functionalization of oxide-free hydrogen-terminated silicon (Si−H) enables predictably tuning its electronic properties, by incorporating tailored functionality for applications such as photovoltaics, biosensing and molecular electronics devices. Most of the available chemical functionalization approaches require an external radical initiator, such as UV light, heat or chemical reagents. Here, we report forming organic monolayers on Si–H surfaces using molecules comprising terminal alcohol (–OH) groups. Self-assembled monolayer (SAM) formation is spontaneous, requires no external stimuli–and yields Si–O–C covalently bound monolayers. The SAMs were characterized by X-ray photoelectron spectroscopy (XPS) to determine the chemical bonding, by X-ray reflectometry (XRR) to determine the monolayers thicknesses on the surface and by atomic force microscopy (AFM) to probe surface topography and surface roughness. The redox activity and the electrochemical properties of the SAMs were studied using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The availability and the ease of incorporating OH groups in organic molecules, makes this spontaneous grafting as a reliable method to attach molecules to Si surfaces in applications ranging from sensing to molecular electronics where incorporating radical initiator setups is not accessible.
Unveiling the Influence of Non-Toxic Fluorinated Ionic Liquids Aqueous Solutions in the Encapsulation and Stability of Lysozyme
Authors: Ferreira Margarida L. , Vieira Nicole S. M. , Araújo João M. M. , Pereiro Ana B.
Published: March 2021

Proteins are bioactive compounds with high potential to be applied in the biopharmaceutical industry, food science and as biocatalysts. However, protein stability is very difficult to maintain outside of the native environment, which hinders their applications. Fluorinated ionic liquids (FILs) are a promising family of surface-active ionic liquids (SAILs) that have an amphiphilic behavior and the ability to self-aggregate in aqueous solutions by the formation of colloidal systems. In this work, the protein lysozyme was selected to infer on the influence of FILs in its stability and activity. Then, the cytotoxicity of FILs was determined to evaluate their biocompatibility, concluding that the selected compounds have neglected cytotoxicity. Therefore, UV–visible spectroscopy was used to infer the FIL-lysozyme interactions, concluding that the predominant interaction is the encapsulation of the lysozyme by FILs. The encapsulation efficiency was also tested, which highly depends on the concentration and anion of FIL. Finally, the bioactivity and thermal stability of lysozyme were evaluated, and the encapsulated lysozyme keeps its activity and thermal stability, concluding that FILs can be a potential stabilizer to be used in protein-based delivery systems.
Disaster Recovery Practices and Resilience Building in Greece
Authors: Coccossis Harry , Delladetsimas Pavlos-Marinos , Katsigianni Xenia
Published: March 2021

This paper aims to elaborate on the notion of resilience by analysing the historical long-term impact of recovery processes that follow catastrophic events. In this respect, the approach reveals the importance of two major dimensions of disaster recovery practices: the establishment of an effective resilience milieu in conjunction with the generation of safety knowledge. The analysis focuses on two island case studies in Greece that experienced devastating earthquakes in the 1950s: Cephalonia (Ionian Sea) and Santorini (South Aegean Sea). Both insular cases underwent a comprehensive and (in many respects) innovative reconstruction process that set the scene for establishing a ‘resilience milieu’ and, in a dialectical manner, a ‘safety culture’, which for many years has been embedded in local development trajectories and influenced spatial growth dynamics.
Post-Pandemic Recovery: A Case of Domestic Tourism in Akaroa (South Island, New Zealand)
Authors: Hussain Asif , Fusté-Forné Francesc
Published: March 2021

The current pandemic (Covid-19) disrupted businesses and challenged societies all over the world. In particular, destinations are being urged to keep the attraction and value of their products and services in post-pandemic tourism recovery programs. Drawing from a qualitative study based on published reports and research, and using participant observation, this research analyses the situation of tourism in Akaroa, South Island of New Zealand, during the coronavirus outbreak and the first stages of the recovery process. Results of the research show that while crisis management led to the closure of the sector due to strict social and travel restrictions, the confinement measures adopted by the government and the progressive reopening of the country has resulted in a shift from “cruise tourism” into a gradual return of “domestic tourism”. This paper argues that local peoples’ perspectives must be kept in mind when developing a tourism recovery strategy. This case study also shows that because of the nature of changing working environment, there is potential to change local demography in the form of an increase in residents putting pressure on local infrastructure. In a rural and marine environment, local stakeholders’ attention is required to focus on “quality” of tourism rather than “quantity”. Nature-based resources and outdoor activities are expected to be the critical ingredients for tourism’s immediate and sustainable future.
Impact of stress on clinical outcomes of non-surgical periodontal therapy in patients with severe generalized periodontitis
Authors: Bebars A. , Romano F. , Giraudi M. , Ortu V. , Sekka I. , Massano E. , Mariani G. M. , Aimetti M.
Published: March 2021

Relevance.Aim – to assess the impact of psychosocial stress on the clinical outcomes in severe periodontitis patients treated with Nonsurgical Periodontal Therapy (NPT).Materials and methods.Patients received 2 psychological questionnaires to score their stress levels, while clinical data were obtained 1 week before and six weeks after the completion of NPT.Results.A total of 55 patients were consecutively included in the study and subsequently categorized into different stress levels (low stress level n = 22 and moderate/high stress level n = 33). All clinical parameters were found to be comparable at baseline between groups. While reduction in full-mouth bleeding scores was found to be statistically significantly lower in group with higher stress levels, a similar improvement in the other clinical parameters was observed at the completion of NPT.Conclusion.Psychosocial stress seems to influence negatively the results of NPT and highly stressed patients may represent a risk category for disease progression.
Condition of the tongue, periodontal and immune statuses in men with alcohol dependence syndrome
Authors: Kunavina K. A. , Opravin A. S. , Soloviev A. G. , Harkova O. A. , Davidovich N. V.
Published: March 2021

Relevance. Oral health problems, particularly periodontal diseases, are frequent complications in people with alcohol dependence syndrome (ADS). The assessment of the periodontal, immune status and the tongue condition in ADS patients by the set of indices is promising. Materials and methods. The periodontal and immune status and the tongue condition were examined in 114 men, of whom 47 were patients with stage II ADS and 67 were subjects without a history of ADS. Pearson's chi-squared test, Mann–Whitney U test, logistic regression, factor analysis were used for statistical analysis. Results. ADS patients have significantly worse oral hygiene (p < 0.001) and 35.5 times higher probability of moderate to severe gum inflammation (p < 0.001). Sextants with bleeding (39.0%) and calculus (25.9%) prevailed among ADS patients whereas most of sextants were healthy (85.8%) in the comparison group. Significant inter-group differences were found for all CPI codes except code 4 (p < 0.001). The dorsal surface tongue coating (63.8%) and minor hyperkeratosis (27.7%) prevailed among ADS patients, while in the comparison group, there were no changes in 34.3% of subjects and coating was present in 38.8% (p = 0.003). The risk of satisfactory to poor oral hygiene was 3.7 times (p = 0.007) higher and the risk of moderate to severe gum inflammation was predicted to be 6.5 times (p = 0.015) higher if the examined subjects had changes in the tongue mucosa. The obtained differences in the level of IgG, TNF-α and cortisol prevailed in ADS patients (p < 0.001). Conclusion. In ADS patients, the severity of periodontal diseases, changes in the tongue mucosa and mucosal immunity imbalance are statistically significant. The considered dental markers of chronic alcohol intoxication are proposed to be used at the treatment and checkup dental visits to screen individuals at risk of alcohol use disorder.
Comparação entre contraceptivos hormonais combinados e progestágenos isolados na efetividade do tratamento da endometriose: uma revisão de literatura / Comparison between combined hormonal contraceptives and progestogens in the effectiveness of the treatment of endometriosis: a literature review
Authors: Pereira Ana Cláudia Costa , Pereira Matheus Moraes Alves , Vale Paula Melo , Silva Rayane Paula Silveira , Arreguy Renzo Camara , Melo Sara Tamna Ventura , Nogueira Taruany Melo
Published: March 2021

INTRODUÇÃO: A endometriose é uma condição ginecológica benigna crônica, hormônio-dependente e é definida pela presença ectópica de tecido endometrial. Dentre as opções de tratamento, o uso de contraceptivos hormonais combinados (CHC) e de progestágenos isolados (PR) é bastante prevalente nos consultórios. Diante disso, o objetivo do presente estudo é analisar e comparar os fármacos citados para avaliar sua efetividade no tratamento da endometriose.  METODOLOGIA: Revisão de literatura realizada nas bases de dados MEDLINE/Pubmed, LILACS e SciELO, com o uso dos descritores “Combined hormonal”, “Hormonal Contraception”, “Progesterone” e “Endometriosis”, juntamente aos operadores lógicos de pesquisa “OR” e “AND”. Incluiu-se artigos em inglês, português, espanhol e francês, com recorte temporal de 2011 a 2021. RESULTADOS: Foram selecionados 22 artigos dos quais 9 analisavam PR, 4 analisavam CHC, 3 analisavam ambos (PR e CHC) e 6 analisavam mais de um tipo de terapia. DISCUSSÃO: Os PR e CHC apresentam eficácia no controle dos sintomas e aumento da qualidade de vida em mulheres com endometriose, portanto, estão indicados como opção terapêutica de primeira linha no tratamento clínico da endometriose. CONCLUSÃO: O presente estudo não foi capaz de elucidar se há superioridade de uma terapia em relação a outra. Diante disso, o tratamento deve ser individualizado.
ПРАВОВЕ РЕГУЛЮВАННЯ РЕАЛІЗАЦІЇ ПРАВА НА ПРАЦЮ В УМОВАХ ЄВРОІНТЕГРАЦІЇ
Authors: Шабанов Р. І. , Ждан М. І.
Published: March 2021

Автори розкривають специфіку правового регулювання реалізації права на працю в умовах євроінтеграції. Вказується, що лише через розуміння необхідності зміни усталеного погляду на право на працю в європейсько-центрованому вимірі Україні вдасться провести ефективні реформи у сфері трудових відносин. Встановлено штучний характер законодавчого закріплення права на працю у СРСР, яке спрямовувалось винятково на реалізацію державотворчих цілей та завдань. У 90-ті рр. ХХ ст. право на працю, як порівняти із радянським розумінням, перетворилося із суб’єктивного права на об’єктивне право та елемент правоздатності. Авторами наголошується, що прийняття демократичного та ліберального Основного Закону України обумовило роздержавлення і повернення до лона універсальних прав людини права на працю, яке за своєю сутністю означає свободу праці. Досліджується природа та зміст права на працю як універсального права людини через концепцію негативної та позитивної свободи. Автори констатують, що в умовах євроінтеграції право на працю має розумітися як можливість людини заробляти собі на життя вільно обраною працею, розвиватися завдяки цій праці та мати гідне ставлення і рівні можливості у сфері праці.
The Theory of Tamil God Murugan
Authors: V Surendran
Published: March 2021

Murugu means beauty. If the beauty means Lord Muruga, he is the lord. Since Lord Muruga is the god of Tamils, murugan is called tamil god. Let us look at the principles of the great Tamil god Murugan. The principle of Lord Muruga is morality, charity should remain in this world. In this article, one can learn that to attain salvation, one should worship Lord Muruga and follow his righteous ness and attain salvation.
A STUDY OF SIRIP DESA AT CITERAS, LEBAK, BANTEN AN ARCHIEVAL INFORMATION SYSTEM
Authors: Astriratma Ria , Irmanda Helena Nurramdhani
Published: March 2021

This study aims to create an archiving information system that can be used to store data held by government officials in Citeras Village as needed. The research stage was preceded by collecting data archives/files contained in the Citeras Village Village. Then the data is processed to be processed in the system. The data obtained is modeled according to system requirements. Then implemented into a web-based system. The output of this research is the availability of an archiving information system as a data storage tool in accordance with the needs of the web-based Citeras Village government device using the SDLC (System Development Life Cycle) Waterfall method. Database design using MySQL and the programming language used is PHP. The result of this research is the availability of a web-based archiving information system for population data in Citeras Village which can then be used by Citeras Village officials, Rangkasbitung District, Lebak Regency, Banten.
Islamic Banking and Finance in Theory and Practice
Authors: Samad Abdus , Gardner Norman D. , Cook Bradley J.
Published: March 2021

This paper’s primary objective is to identify the relative importance of various Islamic financial products, in theory and in practice, by examining the financing records of the Bank Islam Malaysia (Berhad) and the Bahrain Islamic Bank. Currently, seven available Islamic financing products are considered viable alternatives to interest-based conventional contracts: mudarabah (trust financing), musharakah (equity financing), ijarah (lease financing), murabahah (trade financing), qard al-hassan (welfare loan), bay` bi al-thaman al-ajil (deferred payment financing), and istisna` (progressive payments). Among these financial products, mudarabah and musharakah are the most distinct. Their unique characteristics (at least in theory) make Islamic banks and Islamic financing viable alternatives to the conventional interest-based financial system. The question before us is to determine the extent of mudarabah and musharakah in Islamic financing in practice. The data are as follows: the average mudarabah is 5% of total financing, and the average musharakah is less than 3%. The combined average of mudarabah and musharakah for the two Islamic banks is less than 4% of the total finance and advances. The average qard al- hassan is about 4%, while istisna` does not yet exist in practice. Murabahah is the most popular and dominates all other modes of Islamic financing. The average use of murabahah is over 54%. When the bay` bi al-thaman al-ajil is added to the murabahah, the percentage of total financing is shown to be 2.68%. This paper also explores some possible reasons why these two Islamic banks appear to prefer murabahah to mudarabah and musharakah.
Toleration, Political Liberalism, and Peaceful Coexistence in the Muslim World
Authors: Sahin Bican
Published: March 2021

How can Muslim societies marked by religious, cultural, and ethnic diversity secure peace and stability? I argue that the principle of toleration provides the most appropriate environment for the peaceful coexistence of these differences, for individuals living in a polity can adopt different moral views and experience their cultural, ethnic, and other differences peacefully. Toleration is mainly a characteristic of liberal democratic regimes. However, different traditions of liberalism lead to different versions of liberal democracy. Also, not all versions of liberalism value toleration to the same degree. I argue that a liberal democracy based on “political” rather than “comprehensive” liberalism provides the broadest space for the existence of differences, for it does not present a shared way of life, but only a political framework within which individuals and groups with different worldviews can solve their common political problems. However, a liberal democracy based on comprehensive liberalism requires cultural groups and/or individuals to subscribe to fundamental liberal values (e.g., autonomy), and this stance limits its room for toleration. Thus, if liberal democracy is going to be introduced into the Muslim world to bring about peace and stability, it must be a liberal democracy based on political, rather than comprehensive, liberalism.
Not Without My Daughter
Authors: Nazari Hossein
Published: March 2021

As far as literary representations of the Islamic Republic of Iran in the West are concerned, according to Farzaneh Milani, Betty Mahmoody’s best-selling Not Without My Daughter (1987) remains “the most popular book ever published in the U.S. about Iran.” Nevertheless, the book’s unprecedented popularity notwithstanding, it has garnered scant critical attention. Hence, as the first major literary analysis of the text, this paper sets out to illustrate how Mahmoody’s “memoir” functions within the paradigm of the well-established literary tradition of American captivity narratives. In so doing, it demonstrates how the text constitutes a site wherein the three subgenres of captivity narratives – as a religious pilgrimage, a propagandistic tract, and a sensational shocker – converge. It also analyzes the conceptualization of captivity as a condition that transcends the boundaries of the spatial and the physical. Furthermore, analysis of the text reveals how the book’s production and reception were conditioned not only by its construction within the parameters of American captivity narratives, but also by what came to be known in the West as the “Iran Hostage Crisis.” Finally, the production and reception of Not Without My Daughter is critiqued as a testament to the protean nature of American captivity narratives and the genre’s malleability, which allow it to be rehashed and reformulated to align with the dominant sociopolitical zeitgeist at the time of production. Twenty years before Sen. John McCain (R-AZ) would sing, “Bomb, bomb, bomb, bomb, bomb Iran,” to the old Beach Boys tune “Barbara Ann,” the idea was proposed in the most popular book ever published in the US about Iran.
Do amadorismo profissional ao profissionalismo amador
Authors: Mayor Sarah Teixeira Soutto , Silva Sílvio Ricardo da
Published: March 2021

O presente artigo tem como objetivo analisar os discursos produzidos pela imprensa belo-horizontina sobre a profissionalização do futebol, especificamente em relação às tensões observadas entre a modernização almejada com o novo regime e as reais possibilidades do cenário local. Como metodologia, foram analisadas reportagens de jornais e revistas produzidas na capital mineira e em outras localidades, como Rio de Janeiro e Buenos Aires, devido à percepção da circulação de discursos comuns e da influência do cenário futebolístico dessas cidades. A análise das fontes evidencia uma convivência ambígua entre os discursos veiculados, que ora invocavam os supostos avanços do profissionalismo em contraposição à defasagem do amadorismo, ora condenavam o regime profissional em prol dos verdadeiros sentidos do esporte proporcionados pela prática amadora. Longe do apaziguamento que a palavra ‘transição’ pode supor, a mudança de regimes permaneceu durante a década de 1930 como protagonista de um cenário discursivo conflituoso.
INOVASI PELAYANAN PUBLIK MELALUI APLIKASI “E-DUKCAPIL” PEMBUATAN KARTU KELUARGA PADA DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KABUPATEN KARAWANG
Authors: Suwarni Neni
Published: March 2021

This study aims to analyze public service innovations through the application "E-dukcapil" in making family cards at the Department of Population and Civil Registration, Karawang Regency. The research conducted is qualitative research, in this research is descriptive in nature, namely to describe the reality of the events under study. The focus of this research is using the innovation attribute theory by Rogers, namely: (1) relative advantage, (2) suitability, (3) complexity, (4) possibility of experimentation, (5) ease of observation. Through observation data collection techniques, in-depth interviews and documentation. With the number of informants as many as 3 people. The results showed that the innovation of family card services through the "E-dukcapil" application was not entirely ideal. This is because the application has only been implemented for 3 months, and problems such as server disruptions are still common. Lack of public understanding of the use of information technology and the lack of human resources of the implementing apparatus, namely the number of Civil Servants (PNS) in the Department of Population and Civil Registration of Karawang Regency, which is only equivalent to 40 people.
Astrophil and Stella y la interpretación de "The Book of God' s Works"
Authors: Manzanas Calvo Ana Mª
Published: March 2021

"un gran texto único" (1989: 41, 42). Tal vez sea San Victor en Didascalicon quien describa con más riqueza expresiva la correspondencia natural entre "The Book of God's Works", o El Libro de la Naturaleza, y "The Book of God' s Words" o la Escritura:
El uso de "Project Work" en la enseñanza de lenguas extranjeras
Authors: Jiménez Raya Manuel
Published: March 2021

The present paper is the result of my own reflections on the contributions of different people to the field of language teaching and my own experience in a Spanish Secondary School implementing an autonomous learning scheme based on the use of Project Work and learner training as the main classroom  ctivities, although in this article I concentrate exclusively on Project Work. Project Work as defined in this article is the development of a rich, creative experience centred on the learner and his/her surroundings. The experience can be simple or complex but it is based on the interests of the learner. The article advocates the use of this technique in the classroom and attempts to analyse its main characteristics with reference to some methodological aspects. It is maintained that with the use of Project Work the different learning styles and language levels in the group are catered for. It also makes it possible for the teacher to find a balance between accuracy and fluency, allowing, at the same time, for a considerable degree of learner autonomy.
DEVASSOS NO PARAÍSO
Authors: Caruzo Matheus Svóboda
Published: March 2021

O presente trabalho é uma resenha descritiva da obra “Devassos no paraíso: a homossexualidade no Brasil da colônia à atualidade”, escrita pelo autor João Silvério Trevisan. Amplamente divulgado e referenciado desde a sua primeira edição, o título impulsionou uma expressiva interlocução entre ativistas do movimento LGBTQIA+ e pesquisadores do tema, fornecendo um amplo panorama histórico sobre a construção da homossexualidade no Brasil.
ENTREVISTA COM A ENFERMEIRA, EDUCADORA SEXUAL ESPECIALISTA EM SAÚDE PÚBLICA E EM SEXUALIDADE HUMANA - LENA VILELA
Authors: Fagundes Tereza Cristina
Published: March 2021

Maria Helena Brandão Vilela ou LENA VILELA – Membro associada da SBRASH, nossa colega é Enfermeira, Educadora Sexual especialista em Saúde Pública e em Sexualidade Humana pelo Centro de Estudos de Sexualidade Instituto H. Ellis. Como  uma das fundadoras do Instituto Kaplan, foi Diretora Executiva e Coordenadora de Projetos, no Centro de Estudos da Sexualidade Humana. Criadora do Programa Papo Firme declara que sua principal missão é "capacitar Pais e Mães em como abordar e orientar seus filhos sobre a sexualidade".
ASPECTOS SOCIOEMOCIONAIS ENVOLVIDOS NA TRANSEXUALIDADE
Authors: Albuquerque Roberto Nascimento de , Silva Matheus Máximo Rodrigues da
Published: March 2021

O processo transexualizador tem sido motivo de diversas discussões, porém não se observa o mesmo espaço para debater sobre isso sob a visão da pessoa transexual. Nesse contexto, o presente trabalho buscou identificar os aspectos socioemocionais envolvidos no processo transexualizador por meio de um estudo de caso. A coleta e análise de dados proporcionaram a elaboração das seguintes unidades de significados: A descoberta da identidade de gênero; O sofrimento; A transfobia; Motivação para o processo transexualizador; O pós-cirúrgico e o futuro. O processo transexualizador deve ser visto como um direito da população transexual e garantido pelo Sistema Único de Saúde. Além disso, transexuais que passam por esse procedimento aumentam sua autoestima, além de diminuirem o sofrimento psíquico que, muitas vezes, acarreta sérios transtornos mentais e, em casos extremos, o suicídio.
Performance Based Machine Learning Model to Enhance Performance of Students
Authors:   Assistant professor, Department of Computer Science Ganpat University, MCA,, Patel Dr. Bhavesh
Published: March 2021

Machine learning techniques are used by many organizations to analyze the data and finding some meaningful hidden pattern from the data, this process is useful by an organization to take the decision making process. Various organizations used like marketing, health care, software organization and education institute etc used it in decision making. We have used machine learning techniques to enhance the performance of students. It will be ultimately used by educational institute to improve the status of educational institute. This research paper includes Naïve Bayes (NB), Logistic Regression (LR), Artificial Neural Network(ANN) and Decision Tree machine learning techniques. Performance of these models have been compared using accuracy measures parameters and ROC index. This research paper has used various parameters like academic performance and demographic information to build the model. In addition to judge the performance also used some additional parameters to measure the performance like F-measure, precision, error rate and recall. The dataset is collected using survey methodology to build the model. As a conclusion found that the Artificial Neural Network model get the best performance among all the models.
Towards an E journalism Based on Semantic Web Technologies
Authors:   Computer Science Department, Faculty of Computers and information, Fayoum University, Egypt., Ismail Ahmed S. , Al-Feel Haytham ,   Computer Science Department, Community College, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Elbeh Heba ,   Computer Science Department, Community College, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Elkawkagy Mohamed ,   Computer Science Department, Community College, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Published: March 2021

The electronic journalism industry became one of the most important achievements of technology in the two decades. Through online media platforms, information and instant news delivered easily and cheaper than before. In addition to that, e-journalism reduces the time and space needed in traditional journalism industry, and hence improve the information lifecycle beginning from collecting reaching to delivering the news to users in convenient ways. On the other hand, Semantic Web technologies enrich the meaning of web content by converting the unstructured data to structured format. So, our proposed works aims to build robust e-journalism system based on Semantic Web technologies to improve the quality of service for journalists and readers.
Treatment of Waste Water of Educational Institution and Estimating the Cost of the Wwtp
Authors:   Department of Civil Engineering, SRM University, Chennai (Tamil Nadu), India., Maharathi Payal
Published: March 2021

Wastewater discharged from the institutions is white, acidic in nature ,turbidity is higher and high COD and BOD. Higher the values of the carbon dioxide and lower the value of chloride were noted for the waste water. Waste water which is rich in protein and fat content can be used as a feed for animals .Treatment of the waste water from GITA is treated and is utilized further for gardening purposes. The estimation of the entire construction of the plant was calculated and was constructed according to the plan.
现代农村公路设计的要点与常见问题分析
Authors: 何 成海
Published: March 2021

农村公路建设具有不同于高速公路等其他类型道路的特点，做好农村公路的设计工作，有更多的注意事项。论文对现代农村公路特点和居民出行方式进行了分析，在此基础上，立足安全性、便捷性和协调性原则，对农村公路设计要点进行了分析，并列举了农村公路设计中常见的问题。
岩土工程综合勘察在礼县张家村滑坡当中的应用
Authors: 郑 情 , 麻 江涛
Published: March 2021

2017 年“8.7”暴洪强降雨使得张家村易地搬迁安置点周侧地质环境发生破坏，引发了滑坡，影响张家村搬迁安置的正常建设、使用。岩土工程综合勘察是一种综合的手段和方法，在本次滑坡勘察中占决定性地位，并为防治方案提供了重要的技术参数和设计依据。
建筑电气智能化设计及应用浅谈
Authors: 彭 晶
Published: March 2021

通过《智能建筑设计标准》中对智能建筑的定义，分析建筑电气智能化设计的组成要素,从智能家居、智能安防、智能照明、智能配电这几个方向探讨建筑电气智能化设计要点和应用场合。
综放工作面调斜过拐点的设计与实践
Authors: 刘 文利 , 石 永光 , 莘 勇刚
Published: March 2021

在综采工作面过拐点的实际工作中，通过设计合理的调斜法和配比，并采取防止输送机上窜、运输下移、刷帮扩巷等措施，保证了综采工作面顶板的稳定和输送设备的合理搭接，保证了工作面的推进速度和产量，取得了良好的技术经济效果。对此，论文针对综放工作面调斜拐点的设计与实践进行一系列的分析。