bluuebunny/crossref_metadata_2025 huggingface dataset:
Caracterización de comunidades bacterianas establecidas en un reactor biológico fijo para el tratamiento de efluentes domésticos
Authors: Zúñiga Hernández Erandy Mirell , Ramos López Miguel Ángel , Zavala Gómez Carlos Eduardo , Campos Guillén Juan , Ledesma García Janet , Arriaga Hurtado Luis Gerardo , Amaro Reyes Aldo , Sandoval Cárdenas Diana Issell , Rodríguez Morales José Alberto
Published: June 2023

El tratamiento biológico es el más utilizado para las aguas residuales domésticas. El reactor de lecho fijo es una biopelícula de microorganismos capaces de degradar la materia orgánica, y es una alternativa eficiente en comparación con los sistemas convencionales, ya que aumenta la superficie de contacto entre el microorganismo y la materia orgánica. El presente trabajo se centra en la adaptación, aclimatación y uso de lodo activado para la formación de una biopelícula en un biorreactor para el tratamiento de efluentes domésticos con un soporte PET; se comprobó que dicho material es factible para ser implementado como medio de soporte. El sistema de lecho fijo se mantuvo en operación durante 150 días, utilizando agua residual doméstica como sustrato, y evaluando la eficiencia del reactor por medio de parámetros de calidad de agua. La diversidad microbiana se evaluó por análisis de ARNr 16S. Las eficiencias de remoción de la Demanda Química de Oxigeno (DQO) y Demanda Bioquímica de Oxigeno (DBO) fueron mayores del 90 % y se logró la neutralización del efluente con características alcalinas. El tiempo de tratamiento fue de 4 h.  Se identificaron 11 Phylum bacterianos correspondientes para biopelícula y 8 en suspensión, donde los principales grupos bacterianos fueron Proteobacterias, Bacteroidetes y Firmicutes. El tiempo de tratamiento disminuyó en un 50 % respecto a los sistemas convencionales. La identificación de los Phylum permite comprender mejor la complejidad de las estructuras bacterianas en aguas residuales y como interviene en la eficiencia de los procesos del tratamiento de aguas residuales.
Simulation of the rainfall–runoff relationship using an HEC-HMS hydrological model for Dabus Subbasin, Blue Nile Basin, Ethiopia
Authors: Yilma Zemede Landu , Kebede Habtamu Hailu
Published: June 2023

Hydrological modeling is important to provide relevant hydrologic information from limited data. In this study, Hydrologic Modeling System (HEC-HMS) was used to simulate the rainfall–runoff relationship for the Dabus subbasin of the Blue Nile Basin. Daily precipitation and stream flow data from 2002 to 2019 were used as key input data for the model, together with soil and land use/land cover data, and a digital elevation model of the study area. Arc-GIS was employed in combination with Arc Hydro and HEC-GeoHMS tools for terrain processing and translating spatial information into model files for HEC-HMS, respectively. Model calibration was done with data from 2002 to 2014, while the validation was done from 2015 to 2019. Nash-Sutcliffe simulation efficiency (NSE), observation standardized ratio (RSR), and coefficient of correlation (R2) were used to assess the performance of the model. With NSE, RSR, and R2 values of 0.784, 0.334, and 0.816 for calibration, and 0.793, 0.323, and 0.875 for validation, the model simulation of stream flows was found in good agreement with the observed values. Therefore, the HEC-HMS model can be utilized to predict stream flows in ungauged catchments in the Dabus subbasin from measured rainfall data for proper water resource planning and management.
Da casa à escola: a organização escolar primária no município de Riachuelo/RN (1965-1976)
Authors: Araujo Rodrigo Wantuir Alves de , Fernandes Aline de Medeiros , Stamatto Maria Inês Sucupira
Published: June 2023

Estuda-se a institucionalização e expansão do ensino elementar, no Brasil, século XX. Considerando-se a diversidade de instituições educativas no processo de expansão da escola primária e à multiplicidade das denominações, tomou-se o estudo de um caso no século XX para a compreensão da institucionalização escolar no Brasil: o município de Riachuelo no Rio Grande do Norte. Para fins metodológicos, realizou-se uma pesquisa em História Oral, além das investigações documentais e bibliográficas. Constituíram-se entrevistas semiestruturadas com ex-professores que atuaram na educação primária do município de Riachuelo no período de 1965 a 1976. Os modelos de escolas isoladas, como a casa-escola, e os grupos escolares existiram de maneira simultânea, não havendo uma ruptura imediata ou uma linearidade no processo de educação brasileira.
METODOLOGÍAS DE EVALUACIÓN EX-ANTE DE LOS BENEFICIOS ECONÓMICOS DE LA BIOTECNOLOGÍA EN EL CULTIVO DE PAPA EN PERÚ
Authors: De los Reyes Maza y Silupú Santos , Gómez-Oscorima Raquel-Margot , Diez-Matallana Ramón-Alberto , Fernández-Northcote Enrique-N.
Published: June 2023

Las tecnologías agrícolas deben ser evaluadas antes de su implementación para que los tomadores de decisión tengan elementos objetivos para fundamentar su juicio. Dadas las diferencias en los resultados si se emplea métodos determinísticos o probabilísticos de evaluación ex-ante de las tecnologías, se busca determinar cuáles son más eficientes en la evaluación ex-ante de semillas genéticamente modificadas de papa resistentes a la rancha o tizón tardío (causada por Phytophthora infestans) y a la polilla de papa (Phthorimaea operculella). La resistencia a estos agentes bióticos se logra con genes de papas silvestres (modificación cisgénica) que brindan resistencia a rancha y con genes de Bacillus thuringiensis (modificación transgénica) que proveen resistencia a la polilla de papa. Se tuvo el objetivo de comparar las versiones determinística y probabilística de los métodos de presupuesto parcial y cambio de excedentes, aplicándolos al caso de la evaluación de los efectos económicos de liberar las semillas modificadas genéticamente de papa resistentes a rancha y polilla. Se comprueba mayor eficiencia de las metodologías probabilísticas, porque muestran probabilidades positivas y negativas de los beneficios de la tecnología, dando una imagen realista de su éxito esperado, superando a los métodos determinísticos que sólo encuentran valores positivos y únicos. En consecuencia, se recomienda aplicar los métodos probabilísticos por su utilidad en la toma de decisiones gubernamentales, al mostrar rangos de éxito y de fracaso.
A Comprehensive Study on Peppermint Oil and Cinnamon Oil as
Nanoemulsion: Preparation, Stability, Cytotoxicity, Antimicrobial,
Antifungal, and Antioxidant Activity
Authors: Özakar Emrah , Alparslan Levent , Adıgüzel M. Cemal , Torkay Gülşah , Baran Alper , Bal-Öztürk Ayça , Sevinç-Özakar Rukiye
Published: June 2023

Background:

Recent studies have shown that nanoemulsions prepared with essential oils
have significant antimicrobial potential against multidrug-resistant pathogens due to increased chemical
stability. Nanoemulsion also promotes controlled and sustained release, which increases their bioavailability
and efficacy against multidrug-resistant bacteria.

Objective:

This study aimed to investigate the antimicrobial, antifungal, antioxidant, and cytotoxicity
properties of cinnamon essential oil and peppermint essential oil as nanoemulsions compared to pure
forms. For this purpose, analyses of the selected stable nanoemulsions were carried out.

Method:

The droplet sizes and zeta potentials of peppermint essential oil nanoemulsions and cinnamon
essential oil nanoemulsions were found to be 154.6±1.42 nm and -17.1±0.68 mV and 200.3±4.71 nm
and -20.0±0.81 mV, respectively. Although the amount of essential oil used in nanoemulsions was 25% w/w,
antioxidant and antimicrobial activities were found to be more effective compared to pure essential oils.

Results:

In cytotoxicity studies on the 3T3 cell line, both essential oil nanoemulsions showed higher cell
viability than pure essential oils. At the same time, cinnamon essential oil nanoemulsions exhibited a
higher antioxidant property than peppermint essential oil nanoemulsions and showed superiority in the
antimicrobial susceptibility test conducted against four bacteria and two fungi. Cell viability tests determined
that cinnamon essential oil nanoemulsions showed considerably higher cell viability compared
to pure cinnamon essential oil.

Conclusion:

These findings indicated that the prepared nanoemulsions in the current study might positively
influence the dosing regimen and clinical outcomes of antibiotic therapy.
Study on the Effect of Polyoctadecyl Acrylate on Daqing Waxy Oil
Authors: Yang Yihai , Sun Zhengnan , Jing Guolin , Liu Yang , Xu Jianqi , Zhang Lina , Tao Hongyu
Published: June 2023

Introduction:

Crude oil is a complex mixture consisting of different hydrocarbons
such as resins, asphaltenes, aromatics and paraffins. Wax deposition in oil pipelines is
considered to be one of the most serious flow assurance problems.

Method:

In order to obtain a pour point depressant with a better effect on Daqing waxy
crude oil, a model oil containing Daqing paraffin was investigated. Polyoctadecyl acrylate
was prepared by taking polymerization of octadecyl acrylate monomer under the corresponding
reaction conditions. The pour point and viscosity were measured after adding the
pour point depressant into the waxy model oil.

Results:

The experimental results showed that the best pour point reduction effect of polyoctadecyl
acrylate was achieved when the mass of octadecyl acrylate monomer was 40wt%
of the total mass (the sum of the mass of solute octadecyl acrylate and solvent toluene), the
reaction temperature was 80 °C, the reaction time was 6 h, and the amount of initiator was
0.15wt% under the condition that toluene was used as the solvent. The addition of polyoctadecyl
acrylate effectively inhibits the appearance of wax crystals and makes the distribution
of wax crystals more dispersed.

Conclusion:

The optimal pour point depressant concentration was found to be 800 mg/kg.
The alkyl side chains of polyoctadecyl acrylate allow co-crystallization with the waxy
crystals and thus their dispersion, while its polar groups can weaken the interactions between
the wax crystals.
Mushrooms Against Malignancies: from Chemosensitization to Immunopotentiation
Authors: Kumar Soni Vivek , Kumar Ratre Yashwant , Mehta Arundhati , Chandra Sonkar Subash , Kumar Prajapati Santosh , Chaturvedi Navaneet , Shukla Dhananjay , Kumar Vishvakarma Naveen
Published: June 2023

Malignancies have been among the diseases which claim most of the lives
around the globe. They also impact the socioeconomic level as well as emotional
detriments among the near and dear ones. Various strategies and interventions have
been devised to combat these life-threatening conditions. The ill effects associated with
synthetic drugs comprising most of the anticancer drugs enforce looking for an
alternative source for molecules with therapeutic potential. Mushrooms are one of the
most prominent sources of bioactive molecules with diverse medicinal properties.
Various mushrooms have shown their ability to inhibit the proliferation of neoplastic
cells both in in vitro and in vivo investigations. Mushrooms and their active
constituents can affect the various Hallmarks of Cancer. Mushrooms are not only able
to inhibit the proliferation of cancer cells, but they also prevent the onset of
carcinogenesis. The anti-angiogenic property of various mushrooms is indicated in
several research investigations. The immunomodulatory potential and ability to avert
metastasis also aid in the anticancer potential of this wonderful food item. Due to the
high nutritive values of edible mushrooms, they have been suggested as nutraceuticals
and contribute to nutritional management in diseases including cancer. The active
constituents are also proven to have chemosensitizing ability. Preventive management
of cancer and reverting chemoresistance have been sought as promising achievements
in the clinical management of malignant conditions. Moreover, the nutritional values of
mushrooms, along with their therapeutic potential at various fronts against cancer,
make them a strong candidate for clinical application. This also warrants the careful exploration of mushrooms, their nutritive potential, and bioactive constituents against
malignant disorders in laboratory and clinical settings.
An Eco-friendly Practice of Decontamination of Toxicants using Fungi
Authors: Rouf Samim Abdur , Vaseem Huma
Published: June 2023

The advent of industrialization and urbanization has caused rapid
production of various types of domestic, agricultural, medical and technological goods,
such as different types of pesticides, herbicides, cyanotoxin, heavy metals, antibiotics,
dyes, phthalates, etc. Production of these substances has led to the production of
enormous amount of waste materials. Inappropriate discharge and uncontrolled
drainage of these waste materials into the environment have caused their accumulation
in the surrounding environment, causing serious health problems and destroying our
ecosystem. Different methods such as physical, chemical and biological have been
adopted to eliminate these waste materials. However, these methods are cost-effective
and have some side effects. Hence, in this chapter, efforts have been made to
understand the fungal enzymes involved in remediation processes, and their role and
the mechanism of action of fungi have been depicted. Besides that, we have also
discussed different categories of waste and their remediation using fungi, which is an
eco-friendly biological approach to remediate toxic materials.
Mushrooms - A Promising Candidate for the Bio.sorption of Heavy Metals from the Environment
Authors: Yadav Priyanka , Mishra Vartika , Tiwari Pandey Aprajita , Prasad Singh Mohan
Published: June 2023

Heavy metal pollution has become an emerging issue worldwide owing to
its high toxicity, non-biodegradability and persisting nature. Thus, it shows high
bioaccumulative ability in the living system that may lead to carcinogenicities and
several health complications in humans, even at trace concentrations. Their genesis
occurs via both natural as well as anthropogenic activities that have contributed to an
unusual increase in the concentration of toxic heavy metals across the globe. Several
conventional methods, namely chemical precipitation, ion exchange, and membrane
filtration, are being implied for the elimination of recalcitrant metals persisting in the
ecosystem. But these methods have their own shortcomings and offer many limitations
when applied to large volumes and fewer metal concentrations. In this regard, an
alternative treatment method is needed that will overcome major demerits while
remediating pollutants at a large scale without generating any secondary pollutants.
Hence, a variant of the sorption technique, i.e., biosorption, appeared as economical
and eco-friendly alternative treatment technology which is characterized by utilizing a
material of biological origin. Further, in this process, the binding of passive cations
might occur through living or nonliving biomass and aid in the elimination of
contaminants from the aquatic system. The origin of biosorbents may vary in terms of
the different microorganisms used. However, the biomass of macrofungi or mushrooms
has been apprehended as a reassuring class of low-cost adsorbents in effacing toxic
ions. This is because the cell walls of macrofungi are enriched with several functional
groups that provide key aspects in the biosorption process. In this chapter, the
biosorptive propensity of different mushrooms toward metal ions has been accented,
and also insights into mechanisms of biosorption are discussed.
Overview of Attack Surfaces in Blockchain
Authors: Zalte S. , Bhatia H. , Deshmukh R. , Gupta N. , Kamat R.
Published: June 2023

In blockchain technology, cybercriminals exploit new attack surfaces for
non-legitimate persons who wish a dissemination of fake information, encourage cyber
attacks, unethical behavior, etc. Attacks are believed to be attributed to the blockchain
cryptographic architecture, the bottom-line architecture, and the substance in which
they are applied. The main threat is focused on the progressive defense research
activity. It is currently believed that other attacks on the blockchain can be launched
without being able to withstand traditional defenses, a few of which may be used to
deliver any other attack. By delineating these attacks and examining their
countermeasures, it highlights the direction of new research that should be persisted for
safer and more competent use of blockchain. In spite of vulnerabilities and attacks, this
technology offers key features like hashing, immutability and digital signature, which
enrich the blockchain. Researchers also contributed to developing a security shield for
blockchain by using an intelligent combination of these features. Basically, these
features are required to achieve CIA (Confidentiality, Integrity and Authentication).
The contribution of this chapter would be systematically investigating the attack
surface of Blockchain technology. The attack surface is the sum of all conceivable
security risk exposures. It is also the total of all known and undiscovered threats,
possible vulnerabilities, and controls, including all resources. To do this, we set attack
vitality on the attack surface to a variety of attacks.
Preserving the Privacy of Wearable IoT Device Data Using Blockchain
Authors: Sowjanya K.K. , Madavi K.P.B. , Thahniyath G.
Published: June 2023

Personal healthcare has become the most important part of present human
life due to the COVID-19 pandemic. The awareness of one’s health is made easily
available by adopting IoT wearable devices like Fitbit, smart watches, oximeters, etc.
All these devices store sensitive information like a heartbeat, BP, distance traveled,
calories burnt, stress levels, location details, etc., and are stored in third-party data
servers. These servers are vulnerable to illegitimate users and also have a single point
of failure. The personal data of the individuals should be protected along with its
integrity. At the same time, the data stored in the servers should be decentralized to
overcome the problem of a single point of attack. The objective of this article is to
provide a framework that uses SHA-56 for generating the hash code and Blockchain
technology to store the data. Thus, providing privacy, security, and integrity for the
data.
Blockchain for Decentralized Services: On Improving Security and Performance of Distributed IPFS-based Web Applications
Authors: Le V. , Moazeni R. , Moh M. , Agrawal R. , Gupta N.
Published: June 2023

While cloud computing is gaining widespread adoption these days, some
challenges are emerging around the security, performance, and reliability of centralized
cloud resources. Decentralized services are introduced as an effective way to overcome
the limitations of cloud services. Blockchain technology, with its associated
decentralization, is used to develop decentralized application platforms. The
Interplanetary File System (IPFS) is built on top of a distributed system consisting of a
group of nodes that shares the data and takes advantage of blockchain to permanently
store the data. The IPFS is very useful in transferring remote data. This work focuses
on applying blockchain technology to the IPFS to improve its security and
performance. It illustrates different types of blockchain and their advantages and
challenges; it also describes the proposed design and its detailed implementation. For
performance evaluation, we show the performance gains, analyze security
enhancements, and discuss the tradeoffs between security and performance. The
presented work is significant towards more secure, efficient web applications utilizing
emerging blockchain technologies.
Three-tier Network Architecture to Mitigate DDoS Attacks on Hybrid Cloud Environments
Authors: Bhardwaj Akashdeep
Published: June 2023

With the rise of cyber-attacks on cloud systems globally, Cloud Service
Providers, Data carriers, and hosting providers are forced to consider the novel
challenges posed and requirements for attacks and, more specifically, DDoS protection
in large hosting environment setups. This chapter proposes using a multi-tiered
network design based on a Hybrid cloud solution comprising an On-premise solution
and a public cloud infrastructure capable of handling hurricane-sized DDoS storms.
Designing A Framework For Cloud Service Agreements For Cloud Environments
Authors: Bhardwaj Akashdeep
Published: June 2023

Cloud Computing has emerged as the prime IT computing model for on.demand access using a pool of shared resources with the least IT support. Cloud
computing is starting to replace the legacy office IT infrastructure and helpdesk support
system. Corporate and home users alike are hugely turning into cloud service
consumers and moving their data and work to the cloud. Therefore, the Cloud Service
Agreement (CSA) between cloud service consumers and cloud service providers has a
critical significance that can guarantee the highest level of service quality and delivery.
The current CSA parameters and CSA terms tend to fall short of the service delivery
commitments with no common terminology or standard followed industry-wide by the
cloud service providers. Comparing similar service offerings and agreements from
multiple cloud service providers continues to be a complex issue. This chapter provides
a pragmatic approach to Cloud Service Agreements, comparing the current process
with the proposed parameters and the new framework for CSA to determine the role of
various elements and terms in the decision-making process for cloud service
agreements for SaaS, PaaS, IaaS, and STaaS.
Comparing Single-Tier And Three-Tier Infrastructure Designs Against DDoS Attacks
Authors: Bhardwaj Akashdeep
Published: June 2023

With the rise in cyber-attacks on cloud environments like Brute Force,
Malware, or Distributed Denial of Service attacks, information security officers and
data center administrators have a monumental task. Starting from the need to safeguard
the client data, data center security, and ensuring cloud service availability, the team
needs to ensure the highest priority to service delivery performance and functionality
being offered to the service consumers. Organizations design data center and service
delivery to cater to maximize device provisioning & availability, improve application
performance, ensure better server virtualization and end up securing data centers using
security solutions at the internet edge protection level. These security solutions prove to
be largely inadequate in times of a DDoS cyber-attack. In this chapter, traditional data
center design is compared to the proposed three-tier data center architecture design.
The author performed DDoS attacks on both architectures to determine the resilience to
withstand DDoS attacks by measuring the Real User Monitoring parameters and then
validated the data using the Parametric T-Test.
Difusi dan Adopsi Inovasi SiBakul Markethub Free Ongkir DIY di Era Pandemi Covid-19
Authors: Putri Vidiastuti Dwi , Darwin Muhadjir , Ikhwan Hakimul
Published: June 2023

Pandemi Covid-19 di Indonesia berdampak pada penurunan pendapatan dan kesulitan akses pemasaran bagi UMKM. Kondisi ini perlu adanya upaya pemulihan daya beli masyarakat dan fasilitas terhadap pemasaran produk UMKM melalui layanan berbasis online. Inovasi SiBakul Markethub hadir sebagai solusi untuk membantu permasalahan UMKM dengan memberikan fasilitas free ongkos kirim. Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan proses difusi dan adopsi inovasi SiBakul Markethub di Yogyakarta serta seberapa relevan inovasi dikembangkan pasca pandemi. Metode penelitian yang digunakan yaitu deskriptif kualitatif melalui wawancara, observasi dan dokumentasi. Sampel penelitian ini terdiri dari satu konsultan PLUT DIY dan sepuluh UMKM yang mengetahui inovasi SiBakul Markethub. Inovasi SiBakul Markethub merupakan sesuatu yang baru maka terdapat proses difusi inovasi. Terdapat empat elemen difusi inovasi yaitu karakteristik inovasi, saluran komunikasi, jangka waktu dan sistem sosial. Proses adopsi inovasi menurut Rogers terdiri dari lima tahap meliputi pengetahuan, persuasi, keputusan, implementasi dan konfirmasi. Tahapan adopsi masyarakat terhadap SiBakul Markethub berbeda-beda tergantung kategori adopter. Hasil dari proses difusi dan adopsi inovasi memberikan dampak yang signifikan terhadap kenaikan omset. Inovasi SiBakul Markethub masih relevan dikembangkan pasca pandemi karena mendukung UMKM Go Digital. Penelitian ini memberikan kontribusi bagi pengembangan teori difusi inovasi dengan melihat konteks inovasi di masa pandemi Covid-19. Implikasi praktis dari penelitian ini memberikan wawasan kepada pemangku kepentingan terkait strategi pemasaran dan pengembangan layanan dalam menghadapi situasi pandemi.
РОЛЬ ПОЛІМОРФІЗМУ ГЕНІВ У ФОРМУВАННІ ПОРУШЕНЬ ФОЛАТНОГО ЦИКЛУ ТА ЇХ НАСЛІДКИ У ЖІНОК, ХВОРИХ НА СИНДРОМ ПОЛІКІСТОЗНИХ ЯЄЧНИКІВ (огляд літератури)
Authors: Архипкіна Тетяна , Бондаренко Володимир , Любимова Лідія , Місюра Катерина
Published: June 2023

Cиндром полікістозних яєчників (СПКЯ) є найбільш поширеною ендокринною репродуктопатією, актуальність якої постійно зростає. На сьогодні вважається, що формування СПКЯ відбувається на тлі множинних генетичних та епігенетичних змін, і особливе значення приділяється генам фолатного циклу. У даному огляді проведено аналіз літературних джерел щодо ролі найбільш досліджених та клінічно вагомих поліморфних генів фолатного циклу. Дано оцінку значущості зниження активності ферментів фолатного циклу 5,10-метилентетрагідро-фолат-редуктази (MTHFR), метіонін-синтази (MTR), метіонін-синтази-редуктази (MTRR) за наявності поліморфних варіантів генів, які їх кодують (MTHFR алель 677T, MTHFR алель 1298C та MTRR алель 66G), у формуванні гіпергомоцистеїнемії (ГГЦ). Дані літератури свідчать про те, що ГГЦ зустрічається частіше у хворих на СПКЯ, ніж у здорових жінок, та припускається, що вона може бути одним із факторів ризику розвитку даного захворювання й підґрунтям для виникнення притаманних йому метаболічних розладів. Наслідком ГГЦ вважається порушення структури та функції ендотелію і, відповідно, судинного тонусу, що призводить до розладів адекватного ангіогенезу, від якого в значній мірі залежать фолікулогенез, формування домінантного фолікула та якість оваріального резерву, а сама ГГЦ розглядається як чинник ризику розвитку репродуктивних розладів. З того часу, коли вперше з'явилися наукові роботи щодо існування зв'язку між поліморфізмом генів MTHFR, MTR, MTRR й СПКЯ, постійно проводяться дослідження в цьому напрямку та припускається, що зв'язок між поліморфізмами генів фолатного циклу та СПКЯ опосередкований рівнем гомоцистеїну в сироватці крові. Однак отримані результати залишаються вкрай суперечливими. Даний літературний огляд обґрунтовує необхідність подальших досліджень в цьому напрямку з метою з'ясування ролі поліморфних варіантів генів фолатного циклу в якості генів-кандидатів щодо розвитку СПКЯ у жінок репродуктивного віку в українській популяції.
THE DILEMMA OF USE OF THE LEVOTHYROXIN IN PATIENTS WITH HEART FAILURE (literature review and own data)
Authors: Pyvovar Sergiy , Rudyk Iurii , Shcherban Tetiana
Published: June 2023

Systematization of literature data on the use of thyroid hormones in patients with heart failure and the results of own research are given.
The therapy of levothyroxine in patients with heart failure, at the moment of time, remains still an "open book". Several questions remain unsolved: regimen, doses and schedule of levothyroxine use, consequences of this therapy. It is necessary to conduct large, multicenter, prospective, placebo-controlled studies, which should provide information on the safety and impact of levothyroxine on the long-term prognosis of these patients.
Our study shows that the long-term administration of levothyroxine in patients with heart failure and accompanying hypothyroidism has a dose-dependent positive effect on the value of the left ventricular ejection fraction and on the course of heart pathology. The maximum ejection fraction of the left ventricle is observed in patients who took the drug in a dose > 1.2 μg/kg. The use of the drug in a dose > 0.53 μg/kg leads to a probable decrease in the frequency of re-hospitalization within 2 years due to decompensation of heart failure.
Evaluation of hydroxymethylfurfural content in commercial and artisanal bee honey from Los Ríos-Babahoyo
Authors: Salazar Llorente Enrique José , Alvarado Álvarez Hugo Javier , Castro Cano Jamileth Marianela , Sosa Arias Byanka Margarita , Puga Lascano Sonia Alexandra
Published: June 2023

Hydroxymethylfurfural (HMF) is a compound that is produced after heat treatment of honey; that is, they are not present in the initial raw materials and can present a potential health hazard; they are known as chemical processing contaminants. This compound is an indicator parameter of the quality of honey produced spontaneously. Its concentration increases with time and other factors, such as improper heat treatment during processing, storage temperature and mode of transportation. The objective of this research is focused on evaluating the content of HMF present in 6 types of bee honey, 3 commercial brands and three artisanal brands; the honey was from eucalyptus and citrus flowering, and the place where the honey was acquired is in the Province of Los Ríos, since being a geographical area with abundant flora, the primary pollinators are bees (Apis Mellifera). In addition, the honey was heated at different temperatures and time intervals to evaluate whether Hydroxymethylfurfural increases when heat is added to the honey. The present work was carried out at the Technical University of Babahoyo; the commercial and artisanal bee honey were acquired between 1 and 5 days before the assay. For HMF analysis, a UV spectrophotometer was used, as specified in INEN 1637 standards, to determine the absorbance of the standard sample at 284 and 336 nm. The HMF values obtained for the three commercial brand honey and the artisanal brand honey are within limits allowed by INEN 1572 Technical Standard, which is 4_mg HMF/100_g of honey (40 mg HMF/kg of honey) as a maximum limit. The mean values ranged from 0.08 to 1.77 mg HMF-/g honey, while the honey subjected to heating had mean values ranging from 0.08 to 4.43 mg HMF/100_g honey. A high HMF content was determined, which exceeded the maximum limit, leading to the conclusion that commercial and artisanal honey does contain Hydroxymethylfurfural. Still, in small quantities, it is important to use good handling and preservation methods to prolong the product's shelf life.

Keywords: spectrophotometer ; Apis Mellifera ; radiation
Linierisasi Model Sistem Ball and Beam dan Metode Kendali LQG Berbasis MATLAB-Simulink
Authors: Suwardi Hanifah , Choir Anisa Septyaning , Nurrahma Salima , Hudati Imroatul
Published: June 2023

Abstract – There are some unstable control systems, it can be an important problem in control, like systems in aerospace and flight. This can be studied simply in the ball and beam system. The ball and beam system uses an LQG (Linear Quadratic Gaussian) controller to determine the effect of stability and optimal system to reach the set point and the results of the slope angle on the beam at the set point. There is a combination of LQR with the element matrix parameters Q and R which can be searched using a trial and error technique with the condition that the Q matrix is a positive semidefinite while the R matrix is a positive definite matrix. As well as the use of gain Kalman filter as an estimator. Two experiments are given on the Q and R matrix elements which will be used in three distance/position displacement tests. The design of LQG on ball and beam systems is carried out in the MATLAB-Simulink software. Then the results of the angle of inclination of the beam (beam) obtained 14° to make the ball reach a set point of 10 cm, 17° for a set point of 20 cm, and 28° for a set point of 30 cm. Keywords – ball and beam, angle, LQG, LQR, linearizationIntisari –Sistem kontrol yang tidak stabil menjadi sebuah masalah yang penting dalam pengontrolan, seperti sistem dalam aerospace dan penerbangan. Hal ini dapat dipelajari secara sederhana pada sistem ball and beam. Pada sistem ball and beam digunakan pengontrol LQG (linear quadratic gaussian) untuk mengetahui pengaruh stabilitas maupun optimalnya sistem mencapai set point serta hasil kemiringan sudut pada balok (beam) pada titik set point. Terdapat kombinasi LQR dengan parameter matriks elemen Q dan R yang dapat dicari menggunakan teknik  trial and error dengan syarat matriks Q ialah semidefinite positive sedangkan matriks R ialah matrik definit positif Serta penggunaan gain filter Kalman sebagai estimator. Dilakukan dua eksperimen pada elemen matriks Q dan R yang akan digunakan pada tiga pengujian perpindahan jarak/posisi. Rancangan LQG pada sistem ball dan beam dilakukan di software MATLAB-Simulink.  Diperoleh hasil sudut kemiringan beam sebesar 14° untuk membuat ball mencapai di posisi set point 10 cm, 17° untuk set point 20 cm, dan 28° untuk set point 30 cm.Kata kunci – ball and beam, sudut, LQG, LQR, linierisasi
Model Construction of Education Community for Foreign Language Major: A “Great Ideological and Political Courses” Perspective
Authors: Xi Wang , Jiaxin Zuo
Published: June 2023

“Great Ideological and Political Courses” conforms to the goal of talent training in the new era, which is the practical innovation of reforming ideological and political education in universities. At present, the problems of foreign language courses with ideological-political elements in universities are (1) loose cooperation between professional teachers and ideological and political workers, and (2) disconnected goals between teaching and educating students. In this study, the model of education community can help solve these problems, and is constructed from the perspectives of the coordination between professional teachers and ideological and political workers, the formulation of macro-cultivation scheme, and the complementary between professional and extracurricular classes, which will be applied to all aspects of foreign language education at university level, so as to promote the construction of ideological and political theories teaching in all courses (IPTTIAC).
A Cognitive Approach to Expressions of English Metaphors
Authors: Xue Li
Published: June 2023

This paper analyses the three expressions of English metaphors: nominal metaphors; verbal metaphors; adjective metaphors from the perspective of cognitive linguistics. For nominal metaphors, the author starts from metaphorical mapping mechanism, interpreting the different syntactic features of them: as a subject, an object, a predicate, an appositive and a possessive, figuring out the reasons for producing nominal metaphors and its cognitive approach. For verbal metaphors, this paper has, in detail, analyzed three different categories of them: the verbal metaphors with a logical subject predicate collocation; the ones with a logical verb, object collocation; and with a logical subject, predicate, object collocation with the above three kinds of linguistic theories, obtaining the forming mechanism of the verbal metaphors and its working ways in languages. For the adjective metaphors, this paper mainly applies the mapping theory between a source domain and a target domain in Conceptual Integration Theory. A comprehensive, detailed and systematical analysis of adjective meanings in basic adjective metaphors and metaphorical combinations of basic adjectives leads to the following conclusion: the combination of basic adjective metaphors is the result of the “Least Effort Principle” with characteristics of simplicity and popularity. In addition, it also possesses the capability to produce richer metaphorical expressions.
Exploring High School IT Course Teaching Resources in the Context of Educational Digital Transformation
Authors: Zhang Wuwen , Jian Huang , Yu Yang , Guan Yurong
Published: June 2023

The Chinese Ministry of Education initiated the implementation of the “National Education Digitalization Strategy Action” in 2022. The digital transformation of education has become a significant strategy in China’s educational reform and development in the new era, which is of great significance for the construction of high school information technology course teaching resources. This paper first introduces the concept and current situation of digital transformation and discusses the classification and existing issues of current high school information technology teaching resources. Next, it analyzes the future development direction and focus of high school information technology course teaching resources, including the development and utilization of digital educational resources, the construction and application of virtual laboratories, the development of personalized educational resources, the optimization and popularization of online education platforms, and the promotion of educational resource sharing and open education. Finally, this paper proposes development strategies and measures for high school information technology teaching resource construction, including strengthening the construction of educational informatization infrastructure, actively exploring the development and application of personalized educational resources, promoting educational resource sharing, and strengthening educational teaching management.
Brief Analysis on the Artistic Technique of Blurring Narrative Subject and its Extension —Take Yu Dafu’s “Degradation” as an Example
Authors: Chen Ruxin
Published: June 2023

As a representative work of vernacular novels in Chinese new literature, “Degradation” sets up an unnamed protagonist and focuses on his inner world for a deep and comprehensive portrayal, thus forming the main content of the novel. This paper will explore the reason why the protagonist of the novel unnamed and the design idea behind it, discuss the revolutionary significance of this method of vague narrative by contrasting with previous literature, and its extension in other art forms today.
АЛМАЗ ЭЛЕКТРОННОГО КАЧЕСТВА. ИННОВАЦИИ. ИНВЕСТИЦИИ. КРЕАТИВНЫЕ ПРОЕКТЫ
Authors: Лучинин В. , Колядин А. , Ягудаев Ю. , Ильин С.
Published: June 2023

Рассматривается синтетический алмаз электронного качества как материал для формирования отечественной ЭКБ на основе синтетического алмаза. Представлены проект создания серийного производства монокристаллических и поликристаллических пластин и эпитаксиальных структур синтетического алмаза и креативные проекты алмазного микроприборостроения.
КИТАЙСКИЙ РАЗРАБОТЧИК ПОЛУПРОВОДНИКОВЫХ КОМПОНЕНТОВ COREBAI MICROELECTRONICS: ОБЗОР ПРОДУКЦИИ
Authors: Садеков Д.
Published: June 2023

Компания Corebai Microelectronics (Beijing) Co. – известный на рынке Юго-­Восточной Азии разработчик и поставщик аналоговых микросхем и ИС смешанного сигнала. В статье представлен обзор основных категорий продукции Corebai, их ключевые сферы применения.
E-Commerce Website having a Niche in Books
Authors: Bhawarthi Amruta A.
Published: June 2023

Abstract: Everyone knows how expensive schools, colleges, and tuition fees are today. One such expense that everyone unconsciously ignores, is the high cost of college and school textbooks. Buying and selling used books have been the latest thing in the present. The main motive of this paper is to provide the masses, with a way to sell and buy used books Online. In this paper, we will present the working of our website and the intention behind it. Our website, Pustak.com is going to be an online platform that specializes in purchasing and selling second-hand used books. It will be a customer-to-customer platform to buy and sell books. Our website will help customers to browse through a catalog of books. Finally, We want to create an ecosystem where every Reader gets the book he/she wants.
IOT based Smart Agriculture Monitoring System Project
Authors: Satheswaran N.
Published: June 2023

Abstract: The need for efficient and effective agriculture has led to the development of IoT based smart agriculture monitoring systems. This article covers Arduino, GSM modem, WiFi modem, temperature sensor, humidity sensor, water sensor, mini fan, water pump fluid, crystal oscillator, resistors, capacitors, transistors, cables and connectors, diodes, PCBs, LEDs, transformers/a dapters, buttons, switches and IC sockets. The system allows realtime monitoring and control of the environment necessary for cultivation and optimization. Integrated with advanced technology , the solution enables farmers to make data-driven decisions and improve farming.
Determinasi Responsibilitas Tatakelola Keuangan Desa
Authors: Purba Kuras , Saragih Rintan Br. , Purba Sahala
Published: June 2023

This research intends to examine and analyze the competence of human resources, community involvement, supervision, and utilization of information technology that affect the Responsibilities of Village Financial Management in the Brand District of Karo Regency. This type of research is quantitative research and uses primary data. The data collection model used is a questionnaire. The analytical model used in this research is descriptive analysis and multiple linear regression. This research was used in 12 villages in the Brand District, and in each village 4 respondents were obtained, namely the Village Head, Village Secretary, Head of Finance, and one BPD person, so that the total number of respondents was 48 people. This research was conducted in April – May 2021. The results of this research show that human resource skills, community involvement, and technology utilization have a positive and significant correlation to Village Financial Governance Responsibility, while supervision has a negative and significant correlation to Village Financial Governance Responsibility. The contribution of this research is that the existence of human resource skills, community involvement, supervision, and utilization of technology can strengthen the responsibility of village financial governance throughout Indonesia, especially in villages located in the village of Brand District.
Does Institutional Ownership Moderate the Relationship Between the Board of Directors and Risk Disclosure?
Authors: Pijoh Dhea Vania Dominique , Pratama Bima Cinintya , Pramono Hadi , Hapsari Ira
Published: June 2023

The purpose of this study is to dissect the ways in which institutional ownership, the number of years a board has been in operation, and the representation of women on the board each influence the strength of the association between risk disclosure and other parameters. Purposive sampling was utilized to collect data from commercial banks registered with OJK between 2017 and 2021. From 41 different locations, 205 samples were taken. To test their hypothesis, the researchers used a panel data regression model. Several different types of descriptive and inferential statistics tests were utilized in this investigation, including but not limited to likelihood, Breusch-Pagan, and Hausman tests, as well as tests for heteroscedasticity and autocorrelation. We utilize the fixed effect model to analyze the correlation between the variables in Regression Models 1 and 2 based on the results of the aforementioned three preliminary tests for the panel data regression model. According to the data, the presence of female board members has no influence on risk disclosure, but the length of time a board has been in existence and institutional ownership both positively increase risk disclosure. Risk disclosure is linked to board tenure and gender parity, although it is unclear how much of an effect institutional ownership characteristics have on this correlation. The study's goal is to clarify the role that shareholders play on corporate boards. To better use shareholder responsibilities, especially institutional ownership, by companies.
Corporate Social Responsibility dan Ketahanan Perusahaan Dalam Menghadapi Pandemik di Asia Tenggara
Authors: Bahari Asniati
Published: June 2023

This study aims to find empirical evidence regarding the influence of CSR on corporate resilience in facing the COVID-19 pandemic in Southeast Asia during the first and second waves of the pandemic. The independent variable in this research is the company's CSR which consists of economic, environmental and social disclosures, while the dependent variable is company resilience. There were 175 companies as research samples in the first wave and 176 in the second wave. Data is obtained from sustainability reports and annual reports published by each company through its official website. Using SmartPLS 3.3.9, it was found that, both in the first and second waves of COVID-19, overall CSR had a positive effect on corporate resilience. In the first wave, disclosure of economic topics had a positive effect on corporate resilience, but disclosure of environmental and social topics had a negative effect. In the second wave, disclosure of social topics had a positive effect on corporate resilience, but disclosure of economic and environmental topics had a negative effect. The implications of this research show that companies need to disclose their business continuity activities during a pandemic to increase corporate resilience. With the longer the pandemic lasts, social activities are more important than economic and environmental activities. The results of this study can enrich knowledge in the field of sustainability accounting which is useful for company management in managing corporate sustainability and also for investors in choosing their investment objects.
Technology Acceptance Model: Determinans Actual System Use Of E-Bupot Unification Applications
Authors: Izzah Nabila Rif'atul , Istiqomah Dyah Febriantina
Published: June 2023

The research aimed to examine the influence of perceptions, attitudes, and intentions in using the e-Bupot Unification application with the Technology Acceptance Model approach. Survey with the object of Corporate Taxpayers using e-Bupot Unification registered at Jakarta Kebayoran Lama Primary Tax Service Office (KPP) by measuring constructs of perceived ease of use, perceived usefulness, attitudes toward use, behavioral intentions, and actual system use, using a questionnaire instrument to collect primary data on a sample of 110 Corporate Taxpayers. This research analyzed data and hypotheses using the Partial Least Square (PLS) method and SmartPLS 3.0 software. The analysis results show that “Perceived Ease of Use” positively and significantly affects “Perceived Usefulness” and “Attitudes Toward Use”. “Perceived Usefulness” positively and significantly affects “Attitudes Toward Use” and “Behavioral Intentions”. "Attitude towards Use" significantly influences "Behavioral Intention." "Behavioral Intention" significantly influences "Actual System Use."
Contradicciones en la incorporación de la perspectiva de género en la práctica docente en Tijuana, México
Authors: Islas Limon Julieta Yadira , Ojeda Norma , Tovar Hernandez Deysy Margarita , Vinas Velazquez Bertha Margarita
Published: June 2023

Este trabajo analiza los discursos relacionados con la socialización en género entre maestras de educación básica en escuelas públicas de Tijuana, México. Se recurre al enfoque teórico de la perspectiva de género bajo el paradigma de investigación cualitativo-interpretativo y se utiliza información obtenida mediante la técnica de grupos focales. Los hallazgos indican un desfase entre los discursos de las docentes sobre las categorías de género y las conductas y/o actitudes de estas hacia los roles de género que sus estudiantes manifiestan. Por un lado, se presenta un discurso de aceptación hacia la diversidad de género que no corresponden con lo socialmente esperado con los roles asociados al sexo y, por otro, se rechaza el ejercicio de la diversidad tanto entre la población estudiantil como entre el personal docente. Se requieren nuevas estrategias en los programas de formación y actualización docente en materia de género en Baja California.