bluuebunny/crossref_metadata_2025 huggingface dataset:
Mudança no perfil epidemiológico da raiva no Brasil
Authors: Cerqueira Thainá Aparecida Pereira Moura , Luz Rafael Moreira Ancora da , Ribeiro Matheus Lopes , Amorim Giovana Côrtes , Ramos Camila Schulze , Coelho Juliana de Almeida , Eiras Caio de Souza , Gitti Clayton Bernardinelli
Published: September 2023

A raiva é uma doença infectocontagiosa zoonótica causada pelo vírus rábico do gênero Lyssavirus. A transmissão da doença pode ocorrer por meio de quatro ciclos epidemiológicos de transmissão, que são caracterizados por suas variantes antigênicas, demonstrando assim sua alta capacidade de adaptação e sucesso evolutivo. Em todos os ciclos, a transmissão do vírus rábico entre os animais é feita por meio da inoculação do vírus presente na saliva de animais infectados a outros por meio de mordeduras e lambedura de mucosas ou continuidades da pele. Apresenta relevância em saúde pública pela possibilidade de coexistência desses ciclos, podendo ocorrer a disseminação e manutenção do agente em diferentes esferas do ambiente, constituindo-se em alto risco de transmissão, principalmente, por apresentar letalidade de 100% e provocar severa encefalite que cursa com manifestações clínicas neurológicas. Diante disso, objetivou-se realizar uma revisão bibliográfica com o intuito de abordar a doença de maneira ampla, a fim de demonstrar sobre a aplicabilidade das políticas públicas relacionadas à vacinação e medidas profiláticas eficazes contra os ciclos da raiva no território brasileiro, para que seja possível descrever sobre as mudanças epidemiológicas da doença em relação às suas variantes antigênicas. O presente estudo também objetivou demonstrar a prevalência da caracterização antigênica da variante três no território brasileiro, tanto para acidentes com humanos quanto para outros animais.
Qualitative indicators of redcurrant varieties (Ribes rubrum L.) selected by the Professor V.L. Symyrenko Department of Horticulture of NULES of Ukraine
Authors: Andrusyk G. , Andrusyk Y.
Published: September 2023

This study presents the findings on the qualitative indicators of seven varieties of redcurrant (Ribes rubrum L.), five of which are selected by the Professor V.L. Symyrenko Department of Horticulture of NULES of Ukraine. The largest average weight of berries had the varieties 'Buzhanska' (0.58 g) and 'Polyana Holosiivska' (0.59 g). These varieties also stand out among others in terms of maximum berry weight. In certain years of research, the fruits of 'Buzhanska' weighed 1.05 g. The 'Lebidka' variety had the largest cluster weight (6.98 g) due to the large number of berries in it (17 pcs.). The uniformity of berries in the cluster of the studied varieties is average (from 63 to 73% depending on the variety). The highest yields per bush were achieved by 'Buzhanska' (4.20 kg/bush), 'Kyianochka' (4.42 kg/bush) and 'Polyana Holosiivska' (4.0 kg/bush). The varieties 'Jonkheer van Tets' (c.), 'Polyana Holosiivska', 'Buzhanska' and 'Snizhanka' are rich in vitamin C. The highest dry soluble solids content was found in the 'Lebidka' variety (12.94%). The most sugars in the fruit were accumulated by the varieties 'Snizhanka' (5.40%), 'Buzhanska' (5.23%) and 'Malva' (5.13%). The white-fruited varieties 'Snizhanka' and 'Lebidka' are particularly notable for their dessert flavour, as they have the best sugar to total acidity ratio (TAR) among the varieties studied – 4 and 3, respectively, and the highest flavour score (9 points)
DEVELOPMENT OF ILP MARKERS FOR PFKFB4 AND RAS GENES OF AEGILOPS TAUSCHII
Authors: Hordynskyi S.
Published: September 2023

The relevance of this research is determined by the prevalence of cereal crops, particularly common wheat, one of the ancestors of which is Aegilops tauschii. The development of new markers that can be used to study the genetic diversity of cereals is a current issue today. The aim of this study was to develop intron length polymorphism (ILP) markers to investigate the intron length polymorphism of PFKFB4 and RAS genes in Aegilops tauschii, and to assess the potential use of the developed markers for genetic differentiation of Ae. tauschii and Ae. biuncialis. EST sequences were obtained using the NCBI database, and online tools such as CD-HIT, BLAST, and Primer3Plus were employed for primer design. Molecular markers, Aet_ILP_1.1, Aet_ILP_1.2, and Aet_ILP_2, were developed and their efficiency was tested on samples of Ae. tauschii and Ae. biuncialis. Amplified fragments were separated using denaturing polyacrylamide gel electrophoresis and silver staining was performed. The Aet_ILP_1.1 marker differentiated fifteen Ae. biuncialis samples into two groups. The use of the Aet_ILP_1.2 marker revealed additional amplicons in certain Ae. tauschii and Ae. biuncialis samples on electropherograms. The Aet_ILP_2 marker visualized amplicons only in Ae. biuncialis samples. Overall, the results indicate a low level of intraspecific genetic variability in Ae. tauschii using the developed markers, however, they can be effectively utilized for assessing interspecific differentiation between Ae. tauschii and Ae. biuncialis.
THE UTILITY OF METAGENOMIC DATA FOR THE BLACK SEA ECOLOGICAL STATUS ASSESSMENT
Authors: Pavlovska М. , Klepko A. , Prekrasna-Kviatkovska YE.
Published: September 2023

According to Marine Strategy Framework Directive the assessment of marine ecosystems’ environmental status is performed with 11 Descriptors, which are based on biological, physical and chemical parameters. The biological indexes are calculated based on taxonomic structure and distribution of eukaryotic communities. Meanwhile, bacterioplankton is sensitive to anthropogenic impact and is thus a promising indicator of aquatic environment status.

We have tested the utility of ecological pressure index (Pi) calculated with chemical data and bacterial community-based index (microgAMBI) for the assessment of Black sea waters ecological status. According to our estimations Pi varied depending on the chemical data used for its calculation, which indicates the necessity of using a wide range of xenobiotics in complex ecological status assessment. MicrogAMBI indicated that the Black sea surface waters can be characterized by “good” environmental status. “Moderate”, “poor” and “bad” ecological status was shown for 3 stations, yet there were no significant region-specific differences between the shelf zone and the open water.

Actinomycetales, Halomonadaceae and Shewanella relative abundance was associated with higher microgAMBI estimations and respectively with worse ecological status. Meanwhile, positive correlation was found between Synechococcus, Acidimicrobiaceae, Pelagibacteraceae, Rhodobacteraceae, Microbacteriaceae, Polaribacter, Rhodothermaceae and Chloroflexi abundance and “good” ecological status.

Microbial metagenomic data is promising for the complex assessmnet of Black sea waters ecological status, however, more research is needed to validate this approach. The development of metagenomic databases will contribite to increase in precision of microgAMBI calculation and subsequent ecological status analysis.
ASSESSMENT OF HEMATOLOGICAL AND IMMUNOLOGICAL INDICATORS OF BLOOD IN CATTLE FOR "IODINE" PATHOLOGY AFTER THE ACCIDENT AT THE CHERNOBYL NUCLEAR POWER PLANT
Authors: Lazarev М. , Klepko А.
Published: September 2023

Information on the content of the natural stable element iodine (127 I) in the radioactively contaminated territories of Ukrainian Polissia and the impact of its lack in these regions on the physiological indicators of the health of cattle (cattle) were analyzed. It is known that the most polluted territories of Ukraine belong to the Polissia zone, which are characterized as zones with a deficiency of biogenic trace elements in the soil, including iodine. It is also well known that it is radioactive iodine that plays a leading role in the radiation damage to biological objects in almost any nuclear accident when nuclear fission products enter the environment. Chernobyl NPP. Diagnostic signs and the clinical picture of radiation damage to animals by radioactive iodine are quite well described in the scientific literature. However, in our opinion, insufficient attention has been paid to these issues in situations where radioactive iodine affects animal populations in provinces endemic for stable iodine. It is known from the literature that the main clinical picture of stable iodine deficiency in cattle is: short stature, low weight, low productivity, characteristic changes in the hair coat - curliness, long hair, wrinkled skin, bradycardia, hypotonia of the scar, impaired reproductive functions, impaired erythro- and leukopoiesis. But when assessing the state of health of cattle in radioactively contaminated territories during the acute period of development of the Chernobyl accident, researchers noted very similar signs. In active experiments with the artificial introduction of radioactive iodine (131 I) into the body of cattle of various ages, we investigated changes in the physiological state of animals under the influence of various formed doses of radiation of the thyroid gland and confirmed our hypothesis regarding the similarity of the biological effects of radioiodine damage and the clinical picture of stable iodine deficiency . That is, screening of the main physiological parameters of animal health is the key to correct assessments of the degree of damage to the animal organism by radioactive iodine isotopes.
CORRELATION OF SUNFLOWER YIELD WITH FERTILITY INDICATORS OF BLACK SOIL TYPICAL UNDER DIFFERENT FERTILIZER SYSTEMS
Authors: Voitovyk M. V. , Tsyuk O. A.
Published: September 2023

One of the most important properties of the soil is its fertility, which is formed in the process of soil formation and is characterized by the totality of all its indicators. Restoration of soil fertility and its preservation should be a priority task of modern agriculture, as it is one of the important reserves for increasing the production of agricultural products. The purpose of the research was to determine the dependence of sunflower productivity on the physico-chemical and agrochemical parameters of typical chernozem depending on fertilization systems. The following methods were used in the research process: field - determination of the interaction of research objects with natural and agrotechnical factors; laboratory - determination of humus content, physicochemical and agrochemical indicators; statistical and mathematical - conducting dispersion, correlation and regression analysis.

The use of the organo-mineral system of fertilization in crop rotation contributes to the improvement of their physico-chemical and agrochemical indicators of typical chernozem. The highest yield of sunflower is formed under the mineral –2.9 t/ha and organo-mineral fertilization system, which is significantly higher than the option without fertilizers.

Long-term anthropogenic impact on typical chernozems leads to a trend of close correlation of sunflower yield with all indicators of mineral nutrition, except for mineral nitrogen, where the level of correlation was average (r = 0.41±0.24). Correlation coefficients indicate that pH, the sum of absorbed bases affect the increase in the content of humus, the average effect on the increase in the content of humus (r = 0.41), phosphorus (r = 0.62) and potassium (r = 0.65) in the soil layer 0-25 cm.
Partisipasi Masyarakat dalam Penanggulangan Stunting melalui Kegiatan Gizi Puskesmas Kebong Kecamatan Kelam Permai
Authors: Listiani Endang Indri , Yulianti Yulianti , Patriani Ira
Published: September 2023

The purpose of this study was to find out the form of community participation in stunting prevention through nutrition activities at Kebong Health Center, Kelam Permai District and to find out what factors influenced community participation in stunting prevention through nutrition activities at Kebong Health Center, Kelam Permai District. The research method used was descriptive research with a qualitative approach. In this study, the primary data source was data collected directly from the village government, health center, village communities in the Kelam sub-district, as parties related to the stunting management process. The results of the study explain that community participation in the nutrition program for stunting prevention by the Kebong Health Center, Kelam Permai District, namely: Campaign and Declaration of Stunting Prevention, Toddler Posyandu, Tracking of Stunted Babies, Malnutrition Surveillance, Implementation of Pregnant and Toddler Classes, Assistance of Pregnant Resti, Surveillance of Pregnant Women KEK , and the Exclusive Breastfeeding Group, as well as Monev for Stunting Toddlers. Forms of Community Participation in the form of: Labor Participation, Skills Participation, and Social Participation. Stages of community participation in the form of: Participation in Implementation, Participation in Evaluation, and Participation in Taking Benefits. Levels of Community Participation starting from: Consultation, Making joint decisions, Acting together, Providing support. Factors that influence community participation in the nutrition program for stunting control in Kelam Permai District are government intervention, community awareness, close living quarters, and free programs and The inhibiting factors were low knowledge, parents' work, lack of socialization, and inadequate follow-up.
Pengaruh Gender dan Pemahaman Tri Pantangan terhadap Persepsi Mahasiswa mengenai Penggelapan Pajak
Authors: Wardani Dewi Kusuma , Santoso Galih Rohmad
Published: September 2023

This study aims to examine the effect of gender and understanding of tri pantangan on students’ perceptions of tax evasion. The sample used in this study were accounting and management students at the Faculty of Economics, Sarjanawiyata Tamansiswa University from 2019 to 2022 using a convenience sampling technique. This research was conducted using a sample of 122 respondents. After the respondent fills in the questionnaire, the data will be processed presented in the form of a Likert scale. The method used in this research is descriptive quantitastive using primary data. The results of this study are that gender has no effect on student perceptions of tax evasion and understanding of tri pantangan has a negative effect on student perceptions of tax evasion.
Vincristine and Peripheral Neuropathy in Acute Lymphoblastic Leukemia Children
Authors: Thongmak Tipaporn , Yuthasompop Najwa
Published: September 2023

Objective: Peripheral neuropathy is a common neurological side effect in acute lymphoblastic leukemia (ALL) pediatric patients, receiving vincristine treatment. This study aims to explore the frequency, clinical, and electrodiagnosis of peripheral neuropathy of ALL patients.Material and Methods: This study was a retrospective cohort study, using medical record reviews of children who, diagnosed and undergoing treatment for acute lymphoblastic leukemia, from 1st January 2018 till 31st December 2022.Results: One hundred and ninety-seven patients were diagnosed with ALL and received chemotherapy. Ten patients had clinical and electrodiagnostic studies of peripheral neuropathy. B-cell type and high- risk classification were the most common in these patients. The most common symptom was bilateral foot drop and all patients had hyporeflexia. The mean cumulative dose of vincristine was 13.35±2.12 mg/m2. The axonal neuropathy, with motor dominantly and the peroneal nerves, were the highest abnormal finding in electrodiagnosis testing.Conclusion: This report addresses the frequent and clinical of patients with peripheral neuropathy. Foot drop and hyporeflexia might be helpful in early detection of peripheral neuropathy in ALL patients.
Improving the method of providing fuel economy of trucks by means of intelligent transport systems
Authors: Gritsuk Igor , Volkov Volodymyr , Ukrainskyi Eugene , Volkova Tetiana , Kuzhel Volodymyr
Published: September 2023

The purpose of the study is improving the method of ensuring the fuel efficiency of trucks by means of intelligent transport systems in variable operating conditions. The analysis of the processes of ensuring the operational control of the fuel consumption of cargo vehicles shows the perspective of their implementation on the basis of modern intelligent transport systems, the main tool of which is the method of remote monitoring. Remote monitoring of cargo vehicles is an effective tool designed not only for tracking the location and movement of vehicles, but also for a certain number of parameters of their technical condition. A mathematical model of an improved method of ensuring the fuel economy of trucks has been developed, which includes a process and analytical component for estimating limit values, forming optimal characteristics and forecasting technical condition parameters and fuel consumption by the engine and vehicle in the processes of cargo transportation. The mathematical model is built on the basis of differential and algebraic equations developed at KhNADU (Kharkiv National Automobile and Road University), NTU (National Transport University) and personally by the authors, which was adapted with appropriate changes in the part of the initial data and algebraic equations to improve the existing method. The improved method for determining and calculating the fuel consumption of a vehicle in operating conditions is based on the information and software complex (ISK) "Virtual Mechanic "HADI-12"" and the ISK "Service Fuel Eco "NTU-HADI-12"" of Khnadu.

As a result, the authors formulated as a general approach to the formation and improvement of the method of ensuring the fuel economy of a cargo vehicle of category N3 in the conditions of operation by means of intelligent transport systems, and actually the processes of solving the set tasks are based on the implementation of the system interaction of three interrelated components: process, information and analytical.
Methods of specifying the speed measurement of a car on the road during diagnostics
Authors: Zybtsev Yuriy , Kashkanov Vitaly , Vishtak Inna , Voroshylov Pavlo
Published: September 2023

This article describes methods of calibrating car speedometer on the road without expensive equipment. The most accurate results are obtained by using marking elements, for instance, the standard road guard fence. The most practical method is synchronous video recording of speedometer and the display of receiver for satellite signals GPS or/and GLONASS. Also, the Khnadu has substantiated methods of checking a car for acceleration and running out onto the road with simple measuring devices - a speedometer and a phone stopwatch.

Experiments have shown that the real picture of countermeasures does not fit into generally accepted models, and this should be taken into account when calculating the standards of diagnostic parameters - the path and time of exit and acceleration. For check of the car by a known method the horizontal section of the road 2.5...3 km long is necessary. On the most part of the territory of Ukraine such sections are very rare, so it is proposed to check up a car on an acceleration on II and III gears and on a coasting down from 50 or 40 km/h to 20 km/h, using accessible length of 0,5 km.

Behavior of car in such conditions was studied, some unknown specificities are discovered and described. The methods of calculation of control values for time of acceleration and time of coasting are offered. The speedometer is a frequency converter of the output shaft of the transmission or the wheels of the car. It inevitably reflects all the errors caused by the uncertainty of the rolling radius of the wheel, including due to atmospheric conditions, the degree of tire warm-up, vehicle loading and its distribution in the longitudinal and transverse directions, etc. Under these conditions, it is necessary to improve the standless diagnostic methods available to ordinary drivers, i.e. on-the-road inspection methods without complicated or prohibitively expensive equipment. So the calibration of the speedometer is a necessary test step and, in critical cases, must be performed at the beginning and end of each test day. Experimentally estimated the error, the required duration of measurement and speed variation when maintaining it by driver or by cruise control. Grading on GPS better when driving south. Calibration equation was obtained for the 2006 Honda Civic: VGPS = 0,9528 Vspeedo. – 0,83.
The Effectiveness of Solution-Focused Brief Counseling on Marital Intimacy in Mothers of Children with Down Syndrome: A Randomized Clinical Trial
Authors: Mirshafieian Naeimeh , Bokaie Mahshid , Jafari Mir Saeid
Published: September 2023

Background: Parents of children with intelligence and motor problems, including Down syndrome have to spend more time babysitting resulting in less intimacy with their mates. Solution-focused brief therapy is one of the treatments presented in the field of marital intimacy. This study aimed to investigate the effectiveness of solution-focused counseling on marital intimacy in mothers of children with Down syndrome. Materials and Methods: In this randomized clinical trial study, 72 couples were selected among members of the Asemannili Society (Isfahan-Iran) from 19/01/2021 to 20/04/2021. The control group received an educational pamphlet for four sessions (without homework) every other week while the intervention group attended eight 90-minute online counseling programs once a week. Bagarozi Marital Intimacy Questionnaire was completed at baseline, after intervention (8th week), and follow-up period (12th week) by the women and their spouses. Results: The mean scores of marital intimacy between the two groups at baseline (online: 313.23 ± 70.86, pamphlet: 315.92 ± 41.45) compared to the 12th week (online: 370.13 ± 44.63, pamphlet: 332.42 ± 30.39) were significantly different. The analysis of the variance test with repeated observations showed that the effect of group, and time on the total score of marital intimacy and its other dimensions, were significant (P<0.05) for women.Conclusion: Both online and pamphlet counseling can improve marital intimacy in mothers of children with Down syndrome, but online counseling appears to be more effective. Thus, this method is recommended for improving the marital intimacy of these women.
Heme Oxygenase-1 (HMOX1) Gene Polymorphisms, Thrombosis and COVID-19: Correspondence
Authors: Mungmunpuntipantip Rujittika , Wiwanitkit Viroj
Published: September 2023

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Differential Association of Dietary Linoleic Acid and Alpha-linolenic Acid with Adipose Tissue in a Sample of Iranian Adults; A Cohort-based Cross-sectional Study
Authors: Masoumi Seyed Jalil , Mohit Mohsen , Karami Esmail , Hadi Saeid
Published: September 2023

Background: Overweight and obesity are the most critical risk factors for chronic diseases. The quality of dietary fatty acids as one of the factors affecting fat accumulation has received little attention. This study investigates the association between dietary linoleic acid (LA) and alpha-linolenic acid (ALA) with body fat indices in a sample of healthy Iranian adults.Materials and Methods: In this cohort-based cross-sectional study, 3,195 individuals aged 20 to 60 who participated in the Shiraz University of Medical Science Employees Health Cohort study were included. Dietary intake was assessed using a validated 118-item Food Frequency Questionnaire (FFQ), and body composition was assessed by the bioelectrical impedance analysis method. Multiple linear regression adjusted for relevant confounders was used to determine the associations.Results:  Mean dietary intake of LA was 14.20 Â± 7.01 mg/day for men and 13.90 Â± 6.71 mg/day for women. Additionally, the daily intake of ALA was 0.18 Â± 0.18 mg/day in men and 0.17 Â± 0.19 mg/day in women. Dietary intake of ALA for men had an inversely significant association with body fat mass (BFM) (Î²: -0.585, 95% CI: -1.137, -0.032, P=0.038), percentage of body fat (PBF) (Î²: -0.537, 95% CI: -0.945, -0.129, P=0.010), Visceral Fat Area (VFA) (Î²: -2.998, 95% CI: -5.695, -0.302, P=0.029), and Waist to Hip Ratio (WHR) (Î²: -0.689, 95% CI: -1.339, -0.040, P=0.038).Conclusion: Higher dietary ALA intake was associated with lower BFM, BFP, VAF, and WHR in men. The present study confirms that ALA intake should be considered a preventive treatment to improve body composition. However, further research is recommended in this regard.
Postoperative Delirium and Dementia in Patients Undergoing Cardiac Surgery: A Review of Randomized Controlled Trials
Authors: Faramarz Zadeh Reza , Shahabi Raberi Venus , Solati Kooshk Qazi Morteza , Zolfi gol Ali , Kahourian Ozra , GhorbaniNia Rahil
Published: September 2023

Delirium and dementia are considered to be the most significant postoperative neurocognitive complications in patients undergoing cardiac surgery, particularly those aged 60 years and older, which reduces the post-surgery quality of life, prolongs hospitalization, increases costs, and elevated the rates of mortality. Nevertheless, the etiology, risk factors, and predictive biomarkers, have not been well elucidated particularly, in patients with unmanifested underline cognitive impairments. The present study aimed to review the findings on the etiology, factors increasing the risk of incidence, and predictive biomarkers of postoperative delirium and dementia after cardiac surgery, and to describe the suggested pharmacological and non-pharmacological interventions.
The Use of Artificial Intelligence in the Management of Neurodegenerative Disorders; Focus on Alzheimer's Disease
Authors: Khastehband Solmaz , Ghasempour Dabbaghi Khazar , Khosravirad Zahra , Jamalnia Sheida , GhorbaniNia Rahil , Mahmoudikohani Fatemeh , Zakeri Habib
Published: September 2023

Recent advances in artificial intelligence (AI) have shown great promise in the diagnosis, prediction, treatment plans, and monitoring the progression of neurodegenerative disorders. AI algorithms can analyze large amounts of data from various sources, including medical images, quantifiable proteins in urine, blood, and cerebrospinal fluid (CSF), genetic information, clinical records, Electroencephalography (EEG) signals, driving behaviors, etc. Alzheimer's disease as one of the most common neurodegenerative disorders. This study specifically explores the possible application of AI in the diagnosis, prediction, monitoring of disease progression, classifying, finding new biomarkers and drugs, and personalizing treatment plans of AD.
Anticancer Activity of Postbiotic Mediators Derived from Lactobacillus Rhamnosus GG and Lactobacillus Reuteri on Acute Lymphoblastic Leukemia Cells
Authors: Banakar Morteza , Haghgoo Roza , Mehran Majid , Yazdi Mohammad Hossein , Mohamadpour Hadiseh , Iravani Saadi Mahdiyar , Alaeddini Mojgan , Etemad-Moghadam Shahroo
Published: September 2023

Background: Leukemia remains a global health challenge, requiring the exploration of alternative therapies with reduced side effects. Probiotics, particularly Lactobacillus species, have gained attention because of their potential anticancer properties. This study investigated the anticancer and cytotoxic effects of postbiotic mediators (PMs) derived from Lactobacillus rhamnosus GG (LGG) and Lactobacillus reuteri (LR) on acute lymphoblastic leukemia (ALL) cells and peripheral blood mononuclear cells (PBMCs). Materials and Methods: The PMs were prepared by culturing LGG and LR strains and isolating the supernatant. The MTT assay assessed cell viability on ALL Jurkat cells and PBMCs, and apoptosis analysis was conducted using flow cytometry. Quantitative real-time PCR was also performed to analyze BAX, BCL-2, BCLX, FAS, and p27 gene expression levels. Results: The results showed that PMs derived from LGG and LR significantly reduced cell viability in Jurkat cells (P<0.05) but not PBMCs (P>0.05). Apoptosis analysis revealed an increase in apoptotic cells after PMs treatment. Nevertheless, gene expression analysis revealed no statistically significant difference between the treated and untreated groups in BAX, BCL-2, BCLX, FAS, and p27 gene expression levels (P>0.05). Conclusion: Findings suggest that specific PMs derived from LGG and LR possess anticancer properties against ALL cells. This research highlighted the promise of PMs as a cutting-edge and less toxic adjuvant therapeutic strategy in cancer treatment.
COMPARAÇÃO DO NÍVEL DE ATIVIDADE FÍSICA DIÁRIA E CONHECIMENTO SOBRE A DOENÇA PULMONAR OBSTRUTIVA CRÔNICA ENTRE HOMENS E MULHERES
Authors: Albuquerque Sampaio Juliana Albuquerque , Garcia Rejanny Duque Thomaz , Rabahi Marcelo Fouad , Corrêa Krislainy De Sousa
Published: September 2023

A DPOC tem a inatividade física como um fator de piora da condição física. Nota-se a importância do conhecimento sobre a doença para que os doentes consigam um automanejo adequado e alcancem melhor qualidade de vida. O objetivo é comparar o nível de atividade física e o conhecimento da doença entre homens e mulheres com DPOC. Trata-se de um estudo transversal analítico, realizado em uma clínica de pneumologia em Goiânia-GO. Aplicou-se o questionário de Bristol para avaliar o grau de conhecimento sobre a DPOC e o pedômetro para avaliar o nível de atividade física diária. Contou com 38 homens e 32 mulheres, ambos os sexos apresentaram-se em sua maioria (60,5% vs 59,4%)  como severamente inativo, porém nenhuma mulher foi classificada como ativa, enquanto 23,7% dos homens receberam essa classificação. Sobre o conhecimento da DPOC, não houve diferença entre homens e mulheres (p>0,05), eles sabem mais sobre os sintomas (3,45 ±1,06 vs 3,37± 1,16) e a etiologia (3,58± 0,95 vs 3,59 ±1,10) e sabem menos sobre os medicamentos: broncodilatador inalado (0,71± 1,04 vs 1,03± 1,00) e corticoide inalado  (0,39 ± 0,68 vs 0,53± 0,88). Conclui-se que não houve diferença estatística entre homens e mulheres quanto ao nível de atividade física e quanto ao conhecimento sobre a doença.
VII CONGRESSO BRASILEIRO DE FISIOTERAPIA NEUROFUNCIONAL, III CONGRESSO INTERNACIONAL DA ASSOCIAÇÃO BRASILEIRA DE FISIOTERAPIA NEUROFUNCIONAL E II SIMPÓSIO INTERNACIONAL DE SAÚDE FUNCIONAL
Authors: Organizadora Comissão
Published: September 2023

Com o tema “Promovendo a funcionalidade centrada na pessoa e na família”, o VII Congresso Brasileiro de Fisioterapia Neurofuncional (COBRAFIN) recebeu em Fortaleza (CE) cerca 1000 participantes, entre fisioterapeutas, pesquisadores, acadêmicos, pacientes e familiares, que se reuniram para partilhar conhecimento e discutir sobre a funcionalidade humana nos diversos ciclos da vida.

A programação científica contou com a ilustre presença de palestrantes de renome nacional e internacional que abordaram temas atuais e, de extrema relevância cientifica e para aplicação da prática clínica, com um ciclo de 90 palestras, distribuídas nos três dias de congresso, além da apresentação de mais de 400 trabalhos científicos aprovados, entre pôsteres e temas livres.

Para nós, que escolhemos trabalhar com a Fisioterapia Neurofuncional, embasar nossa prática clínica nas evidências científicas deve ser uma rotina exercida com responsabilidade e dedicação profissional. O COBRAFIN foi uma amostra de como a Fisioterapia Neurofuncional brasileira evoluiu e está aperfeiçoando suas práticas a cada dia. O evento também foi uma oportunidade de trocas de conhecimento testemunhando o fortalecimento da nossa especialidade, trazendo grandes discussões sobre os temas que contribuem para o aprimoramento da área.

Agradecemos ao corpo editorial da Revista Movimenta pela oportunidade de deixar este legado científico do VII COBRAFIN. A Fisioterapia Neurofuncional Brasileira continua escrevendo a sua história com muito trabalho, ciência e dedicação.
„Ozdobiona wszelkimi cnotami” cesarska siostra Pulcheria i „roztropna” cesarzowa Atenais-Eudocja – co o epoce Teodozjusza II wiedzieli Słowianie prawosławni w średniowieczu?
Authors: Brzozowska Zofia , Leszka Mirosław J.
Published: September 2023

Obraz cesarstwa bizantyńskiego w połowie V w. i wizerunek władających nim osób w piśmiennictwie staroruskim ukształtował się na bazie stworzonych na Bałkanach przekładów cerkiewnosłowiańskich dzieł trzech historyków bizantyńskich: Jana Malalasa (VI w.), Jerzego Mnicha zw. Hamartolosem (IX w.)  i Konstantyna Manassesa (XII w.). Wykorzystywanie ich przekazów przez autorów chronografów nawet w drugiej połowie XVI w. świadczy o wyjątkowej żywotności historiografii bizantyńskiej i swoistej ponadczasowości utworów wspomnianych dziejopisów. Trzeba  jednak zauważyć, iż Pulcheria, Teodozjusz II, Atenais-Eudocja i Marcjan nie przykuwali uwagi staroruskich historiografów tylko jako osoby mające realny wpływ na bieg wydarzeń w przeszłości. Słowianie prawosławni schyłku średniowiecza postrzegali połowę V w. przede wszystkim jako epokę wielkich sporów o naturę Chrystusa, zakończonych zwołaniem soborów ekumenicznych w Efezie (431 r.) i Chalcedonie (451 r.). Niektórzy zaangażowani w kontrowersje teologiczne swego czasu cesarze i cesarzowe byli na obszarze Slavia Orthodoxa czczeni jako święci. Analiza staroruskich chronografów z XIV–XVI w. pozwala przypuścić, że hagiografia oddziaływała na kreowanie wizerunków tego rodzaju postaci w historiografii. By zrekonstruować całościowy obraz Pulcherii i Atenais-Eudocji w literaturze staroruskiej należałoby zatem przebadać też poświęcone im teksty hagiograficzne.
All-Russian Conference with international participation “History of political and legal doctrines as a scientific and educational discipline”
Authors: Krotkova Natalya V.
Published: September 2023

Review of the All-Russian Conference with international participation “History of political and legal doctrines as a scientific and educational discipline”, held on April 20, 2023 at the Faculty of Law at Lomonosov Moscow State University, offers a wide range of positions on the history of political and legal doctrines. The participants, who are somehow connected with this discipline, express their opinion about its role and place in the modern educational process, its history and content, its significance for the training of lawyers, its general cultural function in the socializa-tion of personality and the formation of an ideological position. The speakers agreed that the post-Soviet period is characterized by a steady decline in the share of theoretical and historical disciplines in our legal education. The general conclusion is made that a disdainful attitude to fundamental legal science, including the history of political and legal doctrines, is fraught with a decrease not only in the level of professional training of lawyers, but also their general cultural level.
Sosyal bilgiler öğretiminde harita okuryazarlığı
Authors: BALCI Ali , YILDIRIM Salih
Published: September 2023

Harita okuryazarlığına ilişkin mevcut durumu betimlemeyi amaçlayan bu çalışmada, haritanın tanımı, kullanımı ve okunmasına yönelik ilgili literatür taranarak sosyal bilgiler dersi öğretim programındaki ilgili kazanımlar tahlil edilmeye çalışılmıştır. Nitel araştırma deseni ile yürütülen çalışmanın verileri doküman incelemesi ve literatür taraması ile elde edilmiştir. Doküman incelemesi (sosyal bilgiler dersi öğretim programı) sonucunda harita okuryazarlığı ile ilişkili 10 alt beceri tespit edilmiş ve bu beceriler ilgili literatür ile betimlenmiştir. Elde edilen veriler doğrultusunda harita okuryazarlığı; coğrafi konumu belirleme, yön tespiti, harita çeşitlerini ve haritalama yöntemlerini bilme, projeksiyonu tespit, haritanın lejantını okuyabilme, haritanın ölçeğini okuyabilme, haritadaki ve arazideki uzaklıkları ve eğimi hesaplayabilme, haritada ve arazide yeryüzü şekillerini belirleyebilme, izdüşüm ve gerçek alanı ilişkilendirme, dijital haritaları hazırlama ve okuma kategorilerinde örnekler verilerek değerlendirmelerde bulunulmuştur.
QALD-9-ES: A Spanish Dataset for Question Answering Systems
Authors: Soruco Javier , Collarana Diego , Both Andreas , Usbeck Ricardo
Published: September 2023

Knowledge Graph Question Answering (KGQA) systems enable access to semantic information for any user who can compose a question in natural language. KGQA systems are now a core component of many industrial applications, including chatbots and conversational search applications. Although distinct worldwide cultures speak different languages, the number of languages covered by KGQA systems and its resources is mainly limited to English. To implement KGQA systems worldwide, we need to expand the current KGQA resources to languages other than English. Taking into account the recent popularity that Large-Scale Language Models are receiving, we believe that providing quality resources is key to the development of future pipelines. One of these resources is the datasets used to train and test KGQA systems. Among the few multilingual KGQA datasets available, only one covers Spanish, i.e., QALD-9. We reviewed the Spanish translations in the QALD-9 dataset and confirmed several issues that may affect the KGQA system’s quality. Taking this into account, we created new Spanish translations for this dataset and reviewed them manually with the help of native speakers. This dataset provides newly created, high-quality translations for QALD-9; we call this extension QALD-9-ES. We merged these translations into the QALD-9-plus dataset, which provides trustworthy native translations for QALD-9 in nine languages, intending to create one complete source of high-quality translations. We compared the new translations with the QALD-9 original ones using language-agnostic quantitative text analysis measures and found improvements in the results of the new translations. Finally, we compared both translations using the GERBIL QA benchmark framework using a KGQA system that supports Spanish. Although the question-answering scores only improved slightly, we believe that improving the quality of the existing translations will result in better KGQA systems and therefore increase the applicability of KGQA w.r.t. the Spanish language domain.
Evaluating Reification with Multi-Valued Properties in a Knowledge Graph of Licensed Educational Resources
Authors: Kieffer Manoé , Fakih Ginwa , Serrano Alvarado Patricia
Published: September 2023

This paper presents the construction of a Knowledge Graph (KG) of Educational Resources (ER), where RDF reification is essential. The ERs are described based on the subjects they cover considering their relevance. RDF reification is used to incorporate this subject’s relevance. Multiple reification models with distinct syntax and performance implications for storage and query processing exist. This study aims to experimentally compare four statement-based reification models with four triplestores to determine the most pertinent choice for our KG. We built four versions of the KG. Each version has a distinct reification model, namely standard reification, singleton properties, named graphs, and RDF-star, which were obtained using RML mappings. Each of the four triplestores (Virtuoso, Jena, Oxigraph, and GraphDB) was setup four times (except for Virtuoso, which does not support RDF-star), and seven different SPARQL queries were experimentally evaluated. This study shows that standard reification and named graphs lead to good performance. It also shows that, in the particular context of the used KG, Virtuoso outperforms Jena, GraphDB, and Oxigraph in most queries. The recent specification of RDF-star and SPARQL-star sheds light on statement-level annotations. The empirical study reported in this paper contributes to the efforts towards the efficient usage of RDF reification. In addition, this paper shares the pipeline of the KG construction using standard semantic web technologies.
Hydrogels as effective wound dressings in support of wounds treatment
Authors: Górska Anna , Mendyk Aleksander
Published: September 2023

W ostatnich latach tematyka skutecznego leczenia ran przybiera na znaczeniu z uwagi na wzrastającą częstotliwość ich diagnozowania, ale również wzrost świadomości społecznej na temat istotności prawidłowej pielęgnacji ran. Ważnym elementem procesu terapeutycznego jest stosowanie materiałów opatrunkowych aktywnie wspomagających naturalny proces gojenia. Zwraca się przy tym uwagę na potencjał opatrunków hydrożelowych, które jako nieadhezyjne, miękkie i elastyczne produkty polimerowe o dużej zawartości wody mogą pełnić rolę bezpiecznej warstwy kontaktowej, redukować poziom bólu, utrzymywać optymalny poziom nawilżenia oraz promować autolityczne oczyszczanie rany.
Opatrunki hydrożelowe dostępne są w dwóch postaciach fizycznych, tj. półstałej (amorficzny hydrożel) oraz stałej (płat hydrożelowy). Z przeprowadzonego przeglądu piśmiennictwa wynika, że są to materiały przynoszące wiele korzyści w terapii ran suchych, słabo sączących i martwiczych, aczkolwiek ich zastosowanie w zaopatrywaniu ran zakażonych i z dużym wysiękiem jest ograniczone. Dlatego dostrzega się potrzebę ich dalszego rozwoju w kierunku modyfikacji właściwości chemicznych, fizycznych i biologicznych, a tym samym rozszerzenia ich funkcjonalności. Aktualne prace skupiają się wokół dwóch zasadniczych strategii, tj. 1) zwiększania skuteczności terapeutycznej przez inkorporowanie do układu substancji czynnej o działaniu przeciwzapalnym i przeciwbakteryjnym lub 2) wprowadzenia różnych czujników wykrywających, lub reagujących na bodźce środowiskowe.
W celu uzyskania produktu odpowiedniej jakości i trwałości stosowania nieodłączną częścią prac badawczych jest szczegółowa ocena właściwości projektowanych materiałów. Odpowiednia elastyczność, wytrzymałość mechaniczna, zdolność pęcznienia i chłonięcia, a także struktura wewnętrzna to czynniki, które należy zbadać dla oceny ich funkcjonalności.
Niniejsze opracowanie ma na celu usystematyzowanie wiedzy na temat opatrunków hydrożelowych oraz wskazanie aktualnych kierunków badań ich dalszego rozwoju. Praca zawiera opis ich właściwości, dostępnych postaci, składu oraz metod badania.
Classificacion del Cancer Laringeo de Acuerdo a su Localizacion y Extension Anatomo-Clinica
Authors: Leborgne Félix E.
Published: September 2023

La literatura sobre el câncer laríngeo es muy vasta y ha sido acumulada en um período relativamente reciente. Afección conocida vagamente en la antigüedad, es recién en el ano 1760 que Morgagni (18) refiere en su carta anatômica No. 28 dos observaciones de Valsalva con descripciones autópsicas bien precisas, acompanadas de Ias historias clinicas correspondientes. Se trataba en realidad de casos de câncer laringofaringeo.
Radioterapia no Câncer do Nasofaringe
Authors: Vieira Antonio Pinto
Published: September 2023

Relatório apresentado em Painel, sobre o Tema Oficial, "Tratamento do Câncer do Faringe", por ocasião do VI Congresso Internacional de Câncer, realizado em São Paulo, em 29 de julho de 1954.
Câncer do Côto Uterino Restante
Authors: Coutinho Alberto
Published: September 2023

O objetivo desta comunicação é apresentar 10 casos referentes ao desenvolvimento do câncer na cérvice em pacientes que sofreram histerectomia sub-total.
A violação positiva do contrato de seguro no âmbito da regulação de sinistro
Authors: Adães Matheus de Mello
Published: September 2023

A concepção da obrigação como processo enseja o reconhecimento de que os contraentes devem cooperar entre si para o adimplemento satisfatório. O vínculo obrigacional é permeado pela boa-fé que, em sua função jurígena, possui o condão de criar deveres aos contraentes. No contrato de seguro, a situação não destoa. Antes o oposto: trata-se de contrato marcado pela necessidade de observância da estrita boa-fé em todas as suas fases, com expressa determinação legal nesse sentido. Ocorre que, em que pese a falta de boa-fé ser expressamente sancionada em determinadas etapas contratuais, o Código Civil não alude a eventuais condutas carentes de boa-fé em sede de regulação de sinistro. Há, portanto, uma aparente lacuna quanto à possibilidade de resolução do contrato de seguro por inadimplemento em sede de regulação de sinistro, diante da ausência de boa-fé de um dos contratantes. Para enfrentar esse problema, o artigo objetiva se debruçar sobre as nuances do contrato de seguro e da complexidade da relação obrigacional, bem assim aferir a boa-fé como dever lateral e suas funções. Ao final, concluir-se-á que o descumprimento do dever de observar a boa-fé estrita também em fase de regulação de sinistro enseja inadimplemento contratual, por meio da violação positiva do contrato, facultando-se a resolução da avença e a indenização da parte prejudicada.
ОСОБЛИВОСТІ ДІЯЛЬНОСТІ АПТЕК У ВОЄННИЙ ЧАС НА ПРИКЛАДІ ЛОКАЛЬНИХ МЕРЕЖ РІВНЕНСЬКОЇ ОБЛАСТІ
Authors: Штрімайтіс Оксана Вікторівна , Карпович Наталія Василівна , Ткачук Оксана Миколаївна , Садовник Ольга Володимирівна
Published: September 2023

Стаття містить відомості про діяльність фармацевтичної галузі під час дії воєнного стану в Україні, зокрема функціонування роздрібної аптечної мережі, у тому числі з екстемпоральним виготовленням ліків, на прикладі локальних мереж Рівненщини: аптеки ТДВ «Рівнефармація» та ТОВ «Укрфарм». Фармацевтична галузь є частиною критичної інфраструктури, адже від її роботи залежить не тільки здоров’я, а й життя українців. Особливість фармацевтичної галузі полягає в тому, що всі її ланки тісно пов’язані між собою: товар прямує від виробника через дистриб’ютора до аптечних мереж, де його отримує кінцевий споживач. І якщо страждає одна з цих ланок, блокується робота й усіх інших. Через повномасштабну війну росії проти України компанії змушені адаптуватися до багатьох нових викликів. У перші тижні повномасштабного вторгнення постали проблемні питання стосовно логістики та доставки лікарських засобів і медичних виробів до аптек, дотримання умов зберігання та відпуску ліків. Уперше була зроблена комплексна оцінка діяльності аптек у воєнний час, у тому числі з екстемпоральним виготовленням на основі аналізу нормативно-правової законодавчої бази, що регламентує діяльність закладів, інтерв’ювання фармацевтів і менеджменту аптек. Дослідження ефективності роботи аптечної мережі проводилося в перший тиждень від початку повномасштабного вторгнення ворога, далі оцінювалась діяльність аптек у перші 3 місяці після цього та особливості роботи восени 2022 року. Також були визначені питання, які постали у воєнний час за різними показниками організації діяльності аптечних закладів, та запропоновані шляхи їх вирішення. Зокрема, для якісної роботи керівникам аптек потрібно було розробити альтернативні логістичні маршрути доставки лікарських засобів і виробів медичного призначення, розподілу та дотримання умов зберігання; аптек з екстемпоральним виготовленням – збільшити обсяги виробництва; фармацевтам – використати практичні навички з комунікації, менеджменту та маркетингу для якісного формування товарних запасів та забезпечення населення необхідними ліками.