bluuebunny/crossref_metadata_2025 huggingface dataset:
Permanent indwelling celestin tubes in malignant esophageal strictures
Authors: Lindholmer C. , Samuelsson S. , Theve N. O.
Published: February 2007

Eighteen patients with unresectable carcinoma of the esophagus were surgically intubated with the Celestin tube. Twelve patients (66.7%) had good palliation and relief of dysphagia. The operation mortality rate was 16.7%, which is in accordance with figures reported for endoscopic intubation of malignant strictures of the esophagus.
Spinal metastases of basal cell carcinoma
Authors: Weshler Zeev , Leviatan Avigdor , Peled Isaac , Wexler Menachem
Published: February 2007

A case of spine metastasis of basal cell carcinoma and review of the literature are presented. The treatment approach is discussed.
Tamoxifen response following no response to orchiectomy in metastatic male breast cancer: A case report
Authors: Hiluard Dennis A. , Wilbur David W. , Camacho Elber S.
Published: February 2007

A male patient with advanced breast cancer had no response to orchiectomy but subsequently enjoyed a 17‐month partial response to tamoxifen 10 mg B.I.D. His tumor estrogen receptor (ER) protein was 555 fmol protein/ml cytosol. The potential role of ER determinations in the selection of therapy for advanced male breast cancer is discussed.
Multiple primary malignant neoplasms
Authors: Lee Shiong S. , Wasiljew Bohdan K. , Song Ki T.
Published: February 2007

A 75‐year‐old man developed neurilemmoma of the left eighth cranial nerve, adenomatous polyp of the sigmoid colon, adenocarcinoma of the prostate, mixed cell type lymphoma of the right neck, and infiltrating ductal carcinoma of the right breast metachronously during a period of 38 years. The cancer of the right breast occurred 7 years after the long‐term stilbesterol treatment of prostatic carcinoma, which suggests a causal relationship between the hormonal therapy and development of breast carcinoma.
Simultaneous occurrence of adenocarcinoma and transitional cell carcinoma as two separate primary tumors in the bladder
Authors: Wiener Marshall , Sarma Deba P. , Weilbaecher Thomas G.
Published: February 2007

We report on a 56‐year‐old man who had two distinct and separate primary tumors of the bladder simultaneously: one mucin‐producing adenocarcinoma and the other a transitional cell carcinoma. Despite local extension of the adenocarcinoma beyond the bladder wall, surgical resection has resulted in a 6‐year recurrence‐free survival of the patient.
The effects of ascorbic acid and butylated hydroxyanisole in the chemoprevention of 1,2‐dimethylhydrazine‐induced large bowel neoplasms
Authors: Jones Frank E. , Komorowski Richard A. , Condon Robert E.
Published: February 2007

Human large bowel neoplasia seems to be caused by environmental carcinogens. The experimental carcinogen, 1,2‐dimethylhydrazine (DMH), must be oxidized in the body to have effect. The antioxidants, butylated hydroxyanisole (BHA) and ascorbic acid, were tested for efficacy in prevention of experimental large bowel neoplasia.

Carcinogenesis was induced in female CF‐1 mice by administering DMH, 20 mg/kg, sq for 24 weekly doses. Test animals received varying doses of ascorbic acid, BHA, or both agents together. Animals were sacrificed when moribund or at 35 weeks. All colons were totally embedded and analyzed histologically.

Ascorbic acid demonstrated no effects on incidence or density of large bowel tumors. Ascorbic acid did increase the ratio of adenomas to adenocarcinomas. BHA decreased the incidence and density of large bowel tumors. The lowest incidence was obtained in the group receiving both agents combined.

It is concluded that BHA is effective in the chemoprevention of DMH‐induced large bowel neoplasms. Ascorbic acid demonstrates only modest effect. The greatest effect on tumor incidence is seen when ascorbic acid and BHA are administered together.
Intraspinal epidermoid cyst
Authors: Sarma Deba P. , Carter Claremont F. , Weilbaecher Thomas C.
Published: February 2007

An intraspinal epidermoid cyst occurring in the lumbo‐sacral region of a 38–year old man with congenital spina bifida occulta is described. Relevant literature on the subject is reviewed.
Medullary carcinoma of the breast: An association with negative hormonal receptors
Authors: Ponsky Jeffrey L. , Gliga Lucius , Reynolds Sheryl
Published: February 2007

The records of all patients undergoing breast surgery at one institution over a 6‐year period were retrospectively reviewed. Twenty‐two cases were found to meet the criteria for designation as medullary carcinoma of the breast. Estrogen receptor assay was performed in 20 cases and was negative in 75% of these patients; those with positive estrogen receptor asssay had very low values. Progesterone receptor assay was performed in 10 of these patients and was found to be negative in 9. The one positive value was very low. Medullary carcinoma of the breast, in spite of a generally favorable prognosis, shows a consistent relationship with negative hormonal receptors.
Bilateral abdominoinguinal incision
Authors: Nambisan R. N. , Karakousis C. P.
Published: February 2007

A successful removal of a very vascular pelvic sarcoma through a bilateral abdominoinguinal incision is presented. The advantages of the incision are that it provides good exposure of the iliac vessels and aids in dissecting the tumor from these vessels. Catheter embolization of the branches supplying the tumor during angiogram helps to decrease vascularity of very vascular tumors.
Carcinosarcoma of the lung with spindle‐cell epithelial component: Report of a case
Authors: Gabriel Juan B. , Ibanez Irene , Kondlapoodi Preetham , Chauhan Prem M. , Hagstrom Jack W. C.
Published: February 2007

A case of primary endobronchial carcinosarcoma with predominant spindle cell squamous carcinoma is described. The spindle cell component has not been previously reported as occurring in pulmonary carcinosarcomas. We suggest that this variety of carcinosarcoma closely resembles sarcoma of the lung histologically and emphasize that a distinction between the two neoplasms is important in view of the generally good prognosis of endobronchial carcinosarcomas.
Malignant mesenchymoma of median nerve: Combined nerve sheath sarcoma and liposarcoma
Authors: Shuangshoti Samruay , Benjavongkulchai Sunpetch , Chittmittrapap Soottiporn
Published: February 2007

A malignant mesenchymoma consisting of nerve sheath sarcoma and liposarcoma occurred in the right median nerve of a 29‐year‐old man who did not have stigmata of von Recklinghausen neurofibromatosis. It produced pain at the affected part, referred pain to the palm, and weakness of muscles supplied by branches of this nerve. The tumor was first excised 1 month after its initial manifestation, but recurred twice and eventually metastasized to the lung within 19 months. It is suggested that aberrant differentiation of the mesenchymal component of the neural crest, the ectomesenchymal structure, has created this combined sarcoma of nerve sheath and liposarcoma, forming a malignant mesenchymoma.
Branchiogenic carcinoma (Malignant branchioma)
Authors: Rónay P. , Bodó M. , Zemplén B.
Published: February 2007

The authors describe the characteristics of branchiogenic carcinoma as that of a pathological entity on the occasion of reporting four cases. The clinical course of the disease and the cytological and histological features are discussed on the basis of our observations and literature data. The authors stress the importance of careful and repeated clinical examinations, which exclude the possibility of a primary tumor of other localization, in establishing the diagnosis of branchiogenic carcinoma.
Fatty changes and metastases in axillary lymph nodes
Authors: Werbin Nahum
Published: February 2007

A variety of pathological changes with clinical and prognostic significance is described in axillary lymph nodes removed at mastectomy. We studied 572 lymph nodes removed from 43 women and 1 man during a radical or modified radical mastectomy performed for carcinoma of the breast. We found that in about one‐third of the specimens some degree of fat infiltration, or changes, was present; metastases were found in either fatty or nonfatty lymph nodes. We conclude that the presence of fat in axillary lymph nodes does not influence implantation of tumor cells from a primary carcinoma of the breast and has to be reported as an anatomic variant.
Fluorescent histochemical demonstration of estrogen and progesterone binding in giant cell tumors of bone: Preliminary observations
Authors: Malawer Martin , Bray Michael , Kass Mary
Published: February 2007

Hormonal receptors of giant cell tumors (GCTs) have not been previously reported. Five cases of GCT of bone were analyzed for estrogen and progesterone binding. Frozen sections were studied by a histochemical method, using 17‐beta‐6‐CMOBSA‐FITC and 11‐alpha‐hydroxyprogester‐one‐HS‐BSA‐TMRITC. Cytoplasmic fluorescence with estradiol‐BSA‐FITC was seen in stromal cells of all five tumors; three also showed cytoplasmic staining with progesterone‐BSA‐TMRITC. No fluorescence was seen in the giant cells. Two cases were also analyzed by a dextrancoated charcoal cytosol assay. No estrogen or progesterone receptor was detected by cytosol assay. This study suggests that the estrogen and progesterone binding is present in GCT of bone, possible to low‐affinity sites rather than high‐affinity receptors. Further investigation of hormonal receptors of GCTs of bone is warranted.
Assessment of the role of surgery for stage III bronchogenic carcinoma
Authors: Hara Nobuyuki , Ohta Mitsuo , Tanaka Koichi , Ichinose Yukihito , Noge Sazahito , Miyazaki Kazuhiro , Ishimatsu Toyohiro
Published: February 2007

In order to assess the role of surgery for stage III bronchogenic carcinoma, we reviewed our results of 282 patients who were treated with surgical resection or various other therapy modalities. The survival in patients who underwent surgical resection was significantly better than those with nonresectable carcinoma. However, superior survival results were demonstrated only in patients with complete resection. In contrast, the survival in patients with palliative resection was similar to that in patients with exploratory thoracotomy and inoperable carcinoma. On the other hand, all patients with T3N2 lesions died of their disease within two years after surgery even when undergoing complete resection. Thus, we conclude that radical resection should be indicated in patients with T3N0–1 and Tl–2N2 lesions if complete resection is expected.
Combined paraganglioma and glioma of conus medullaris and cauda equina
Authors: Shuangshoti Samruay , Suwanwela Nitaya , Suwanwela Charas
Published: February 2007

A mixed paraganglioma and glioma occurred in the conus medullaris and cauda equina of a woman. The tumor was subdural, encapsulated, and vascular. It was first manifested with symptoms and signs of compression of the cauda equina when she was 19 years of age and was excised when she was 24. The tumor was attached to the conus medullaris, the dura mater, and a nerve root of the cauda equina. Striking light and dark cells with an organoid arrangement mingled with a few glial fibrillary acidic protein (GFAP)‐positive neuroglia forming a combined paraganglioma and glioma. Twenty‐three paragangliomas were reported in the literature including the present case. The sex and age of recorded 19 patients demonstrated ten males and nine females with an average age of 46.3 years. Twenty tumors were subdurally situated at the conus medullaris and cauda equina. Three neoplasms were epidural and thoracic in location.
Endodermal sinus tumour of the ovary: Serum alpha fetoprotein dynamics and mmunohistochemical localization of marker in tumour tissue
Authors: Buamah Paul K.
Published: February 2007

The apparent successful treatment of endodermal sinus tumour of ovary is reported. The patient, after surgery and adjuvant chemotherapy, has remained in remission, and the serum alpha fetoprotein has been less than 10 μg/l over a period of 9 months.
Anaesthesia and development of some experimental tumours
Authors: Frid I. A. , Evtjukhin A. I. , Bernstein M. I. , Rudakov V. F. , Dunajevski I. V. , Ostroumova M. N. , Moskalik K. G.
Published: February 2007

Present work is based on the data of experimental studies on the influence of inhalatory (ether, chloroformum, halothane and methoxyfluorane) and intravenous anaesthesia (neurovegetative block and neuroleptoanalgesia) upon the tumour growth and metastasization as well as the level of corticosteronemy in surgical trauma.

It has been revealed that the narcosis may change the course of the tumorous process both by means of its action on the endocryne part of the organism‐tumour system and immediately (halothane) due to its cytostatic action.

Obviously, anaesthesia may appear one of the factors influencing the results of multifactoral therapy of tumorous diseases.
Late occurrence of malignancy in a ganglioneuroma 19 years following radiation therapy to a neuroblastoma
Authors: Keller Steven M. , Papazoglou Savvas , McKeever Paul , Baker Alan , Roth Jack A.
Published: February 2007

Neuroblastoma is a common solid tumor of childhood. Maturation to a ganglioneuroma or regression has been reported to occur spontaneously or following minimal treatment. Malignant degeneration of such a ganglioneuroma is extremely rare. We present a report of a malignant tumor arising in a ganglioneuroma 19 years following abdominal radiation therapy for neuroblastoma.
Metastatic carcinoma in inguinal hernia sac
Authors: Chen Karl T. K.
Published: February 2007

A patient with unexplained low back pain, weight loss, and pulmonary infiltrate underwent an inguinal herniorrhapy. Histologic examination of the grossly normal hernia sac revealed metastatic adenocarcinoma. The patient died of cachexia 10 months later. This case observation suggests the necessity of histologic examination of grossly normal hernia sacs.
Unusual presentation of carcinoma of the vermiform appendix: A report of two cases
Authors: Waizbard E. , Michowitz M. , Baratz M. , Papo J. , Stavorovsky M.
Published: February 2007

Two unusual presentations of perforated mucoid adenocarcinoma of the appendix are described. One patient presented with a large periappendicular abscess that extended into the gluteal region, the other with a retroperitoneal abscess and abscesses in the right flank and groin. Recognition of the source of the abscess may be difficult but is essential for the prevention and elimination of the sepsis which may be life‐threatening. The presence of mucin in the drained pus is highly suggestive for perforated bowel carcinoma. A high index of suspicion and the performance of prompt diagnostic procedures may bring early surgical treatment and better results.
Combination chemotherapy for metastatic carcinoma of the ampulla of Vater—report of three cases
Authors: Bukowski R. M. , Hermann R. E. , Theodors A.
Published: February 2007

Three patients with metastatic carcinoma of the ampulla of Vater received celiac artery infusion of 5‐fluorouracil, adriamycin, mitomycin‐C, and streptozotocin followed by intravenous administration of the same combination. In two patients with measurable disease, one partial (6.0 months) and one complete response (16.0 + months) occurred. Two out of three patients remain alive at 30.0+ and 21.0+ months. Carcinoma of the ampulla of Vater may be a neoplasm responsive to combination chemotherapy.
“Early” tongue carcinoma
Authors: Razack Mohamed S. , Sako Kumao , Ring Alejandro H.
Published: February 2007

This is a retrospective study done in 89 patients who were treated for stage I lingual carcinoma, to determine the local control and 5‐year salvage rate and the site and frequency of recurrences with salvage rate with a second modality.
High‐dose versus low‐dose CMFP regimen in advanced breast cancer
Authors: Kumar Anand , Khanna N. N. , Pant C. C. , Khanna S.
Published: February 2007

Fifty cases of advanced breast cancer (stages III and IV) were treated by combination chemotherapy. The study compares the two different dose schedules and toxicities of a combination of cyclophosphamide, methotrexate, 5‐flurouracil, and prednisone. Results are better with high‐dose regimen, though the incidence of toxicity is much as compared to low‐dose schedules, but, considering the beneficial response, the high‐dose schedule is recommended.
Near‐total gastrectomy
Authors: Takagi Hiroshi , Morimoto Takeshi
Published: February 2007

Total gastrectomy has more frequent and serious postoperative complications than subtotal gastrectomy. An esophago‐gastric stoma with a side‐to‐side anastomosis permits a near‐total gastrectomy to be undertaken with virtually the same results as a total gastrectomy. This procedure is used for early gastric cancers that have widely spreading, single or multiple lesions, or lesions near the esophago‐gastric junction, and for the cure or palliative resection of selected patients with advanced gastric cancer.
Lipomatous meningioma associated with cerebral vascular malformation
Authors: Kasantikul Vira , Jan Brown W.
Published: February 2007

A unique epileptic patient with intracranial neoplasm is reported in which a meningioma with lipomatous and osseous components was found associated with cerebral arteriovenous malformation at the same location in the right frontal lobe. The development of the leptomeningeal neoplasm may have been influenced by the underlying vascular anomaly. The cerebral arteriovenous malformation and altered hemodynamics also could have induced the sudden onset of clinical seizures, hemiparesis, and unconsciousness.
Scheduling of combination chemotherapy for a murine melanoma, with the subrenal capsular assay
Authors: Raina Suresh , Hill Helene Z. , Hill George J. , Rush Benjamin F.
Published: February 2007

The effect of varying schedules for administration of two drugs, dimethyl triazeno imidazole carboxamide (DTIC) and methylcyclohexyl chloroethyl nitrosourea (MeCCNU), was studied using the Harding‐Passey Mouse melanoma in the subrenal capsular assay. The results of the assay indicate that the responses of the tumor varied depending on the schedule of administration. The best response, with a mean decrease in dimensions of 3.0 ocular micrometer units (± 1.12 SD), was noted with administration of DTIC on day 1 after tumor implantation, followed by MeCCNU on day 2. These results are similar to previously reported data in CD2F1 mice bearing intraperitonal Harding‐Passey melanoma and suggest that the subrenal capsular assay may be of use in determining the best combinations and schedules of administration for treatment of tumors.
Epidemiology of cancer of the cervix in greater bombay
Authors: Jussawalla D. J. , Yeole B. B.
Published: February 2007

An attempt has been made to study in depth the cervical cancer problem in Greater Bombay by undertaking epidemiological investigations to identify its aetiology, by utilising the data collected by the Bombay Cancer Registry. Although cancer of the uterine cervix is found to occur at all ages in Bombay, it is mainly seen during middle age. Its incidence is highest in the Hindu community and lowest in the Parsi. This neoplasm appears to have a strong association with the degree of sexual activity. Thus it is rarely seen in nuns, and commonly found in women who have had multiple sexual partners. There is also a relative preponderance in the poorer, uneducated section of the community. In order to identify the high‐risk groups, a retrospective study was undertaken of proven cases of cancer of the uterine cervix. The results were compared with those of similar controls, equal in number and closely matched for age, religion, and income, in order to examine the risk factors of possible aetiological importance in women with cervical cancer. We have sought to estimate the effects of parity, the age at first marriage and at first delivery. The highest risk was observed in women who had had multiple pregnancies early in life. It is interesting to note that multiparity seems to be an important risk factor in Bombay women, in contrast to the Western experience.
Renal cell carcinoma in a horseshoe kidney
Authors: Wiener Marshall , Sarma Deba , Rao Moparty
Published: February 2007

A case of renal cell carcinoma arising in a horseshoe kidney and presenting with a pathologic fracture of humerus is reported. Relevant literature is discussed.
Hemicorporectomy—perioperative management: A case presentation and review of literature
Authors: Shafir M. , Abel M. , Tausk H. , Norton L. , Miller Th. R. , Aufses A. H.
Published: February 2007

Hemicorporectomy, or translumbar amputation, is a dramatically drastic surgical salvage procedure for patients with uncontrolled locally extensive pelvic‐perineal malignancies. Several successful cases have been reported in the world literature [3–6] and careful perioperative management has been crucial. The case presented is that of a massive recurrent chondrosarcoma of the pelvis with special emphasis on close monitoring and finely tuned supportive care; unusual manifestations of neuroleptic malignant syndrome and of narcotic withdrawal are discussed.
Advanced leiomyosarcoma of the stomach
Authors: Celik Cihangir , Lopez Cecelia , Douglass Harold O.
Published: February 2007

Retrospective studies of twelve patients with advanced gastric leiomyosarcomas were undertaken to evaluate radical surgical resection and combined modality treatment with regard to the patient survival and symptom palliation. All but one patient were found to have metastases or involvement of adjacent organs at the initial operation. Despite radical resection, multidrug chemotherapy, and radiation therapy, no patient survived beyond the third year. Patients with objective response to chemotherapy and radiation and chemotherapy had a mean survival of 27 months, while those who did not respond survived only 7 months. The longest survival among untreated group was 8 months. Successful palliation of advanced gastric leiomyosarcoma requires early diagnosis, surgical resection and multimodal therapy.
Small bowel exclusion from the pelvis by a polyglycolic acid mesh sling
Authors: Devereux Dennis F. , Kavanah Maureen T. , Feldman Merrill I. , Kondi Edward , Hull David , O'brien Michael , Deckers Peter J. , Mozden Peter J.
Published: February 2007

Radiation enteritis is seen in patients receiving radiation therapy for various pelvic malignancies. Attempts to prevent this have included various surgical as well as nutritional approaches with little success. The use of a polyglycolic acid mesh sling sewn above the pelvic inlet has prevented small bowel descent into the true pelvis in rats and in humans. The technique has been successful in both with no attendant morbidity during an 11‐month follow up. Several patients have received additional doses of radiation therapy that would not have been given if the small bowel were not removed from the area to be irradiated.
Prolonged remission of metastatic malignant fibrous histiocytoma induced by combination chemotherapy
Authors: Clamon Gerald H. , Robinson Robert A. , Olberding Elizabeth B.
Published: February 2007

A patient with metastatic malignant fibrous histiocytoma (MFH) achieved a complete remission with polychemotherapy lasting 42+ months. In view of this long‐term survival and two similar prior reports of long‐term survival after aggressive treatment, the goal of therapy for metastatic MFH must be reconsidered.
Results and complications of staging laparotomy in hodgkin's disease
Authors: Wobbes T. , Lubbers E. J. C. , De Pauw B. E.
Published: February 2007

Between 1969 and 1983, 123 patients with Hodgkin's disease underwent a staging laparotomy. The stages of 34 (27%) patients were changed by laparatomy. Twenty‐nine patients (23%) were upstaged, five (4%) down‐staged. The most considerable change was found in stage III. The accuracy of preoperative lymphangiography was 85%. The postoperative complication rate was 15%. There were no operative deaths. The staging laparotomy for Hodgkin's disease is a reliable procedure, and allows less aggressive therapy in selective groups.
The role and value of surgery in metastatic renal adenocarcinoma: A retrospective clinical study of 106 nephrectomized cases
Authors: Appelqvist Pertti
Published: February 2007

The results of treatment of 106 consecutive nephrectomized cases with metastatic renal adenocarcinoma were analyzed. Over 50% of the patients were dead at 1 year and more than 80% at 2 years from the first metastases. The corresponding 5‐year survival rate was 7.3%. Fourteen patients demonstrated a response to radiotherapy, hormonal therapy, cytotoxic drugs, or active specific immunotherapy. The 5‐year survival rate of the responders was 14.3% from the first metastases. The 5‐year survival rate for 22 patients presenting with only one metastasis was 32%. The corresponding figure for patients presenting with multiple metastases was 1%. Complete excision of metastases was possible in 12 patients, whose 5‐year survival rate was 58.3%. All patients with solitary metachronous metastases completely excised lived 5 years or more. It seems that a small number of metastatic renal adenocarcinomas are slow‐growing tumors that may simulate a favorable effect of a therapy, but at the same time such disease with nephrectomy, usually with minor tumor burden, in fact may also react better to the treatment, and this feature can cause difficulties in judging the value of any therapy in metastatic renal adenocarcinoma.
Postoperative adjuvant mediastinal radiation in lung cancerxs
Authors: Steinfeld Alan D. , Glicksman Arvin S.
Published: February 2007

Postoperative adjuvant mediastinal radiation therapy was used in a group of 18 patients with advanced (nine Stage 2, nine Stage 3) non‐small cell carcinoma of the lung who had undergone curative resection. All patients had metastases to hilar and/or mediastinal nodes. The disease‐free survival at 2 1/2 years was 55% for Stage 2 patients, suggesting a survival advantage compared to historical controls. No benefit was found in Stage 3 patients. A prospective randomized study of adjuvant radiation in node‐positive patients is indicated.
Neuromuscular hamartoma
Authors: Chen KARL T. K.
Published: February 2007

A rare case of neuromuscular hamartoma, a benign tumor composed of well‐differentiated skeletal muscle and nerve fibers, is described and compared with four previously reported cases. The tumor arose in the major peripheral nerves. Three of the five tumors were congenital tumors. A biopsy is essential in establishing the diagnosis. However, the tumor may be left alone if it cannot be separated from the nerve with ease, since spontaneous regression has been documented.
A unique surgical approach for massive retroperitoneal tumors
Authors: Molt Patrick , Shafir Michail , Aufses Arthur H.
Published: February 2007

A unique approach to retroperitoneal tumors is described, utilizing an inverted U‐shaped incision that allows exposure of the retroperitoneum, great vessels, and intraperitoneal organs.
Utility of the abdominoinguinal incision in the resection of lower abdominal tumors
Authors: Karakousis Constantine P.
Published: February 2007

The abdominoinguinal incision provides exposure and renders resectable large tumors located in the lower retroperitoneum, the area of external iliac vessels, and the wall of the pelvis. It is particularly useful for tumors manifesting fixation to these areas.

It has been used successfully in 18 patients with malignant tumors and may be expected to increase substantially resectability of tumors in this area and to decrease the need for hemipelvectomy.
The polymorphic apocrine nevus: A study of a unique tumor including carcinoembryonic antigen staining
Authors: Schwartz Robert A. , Rojas‐Corona Rogelio , Lambert W. Clark
Published: February 2007

The apocrine nevus is a rare tumor. We report a 32‐year‐old man with a neck nodule, histologically an apocrine nevus displaying mature and immature apocrine structures in a distinctive pattern. The carcinoembryonic antigen staining was positive intracellularly only in the smaller luminal structures. We have named this unique tumor a polymorphic apocrine nevus.
Hepatic artery catheterization via the superior pancreaticoduodenal artery
Authors: Au Francis C. , Tyson R. Robert
Published: February 2007

The superior pancreaticoduodenal artery is a continuation of the gastrod‐uodenal artery. Besides being a good‐sized artery, it is easily accessible. It is a reasonable vascular access for hepatic artery cannulation.
Bilateral malignant brenner tumor of the ovary
Authors: Chen Karl T. K.
Published: February 2007

The clinicopathologic features of a case of malignant Brenner tumor with bilateral ovarian involvement are described. The tumor was apparently confined within the ovaries at initial laparotomy. However, multiple skeletal metastases developed 4 months later and the patient died of the disease 6 months after diagnosis.
Dysgerminoma of the ovary
Authors: Jose Baby , Mendoza Enrique , Chu M. , Sharma Subhash
Published: February 2007

Dysgerminomas of the ovary are rare germ cell tumors. They are more common at puberty. Surgery followed by irradiation has resulted in excellent cure rates in early stages of this disease. This paper is a review of six patients with a diagnosis of dysgerminoma who were treated at the Department of Radiation Oncology, University of Louisville. The controversy on the use of irradiation in Stage Ia tumor is discussed in detail. A review of the literature is also done in this paper.
Hickman‐broviac catheter use in cancer patients
Authors: Landoy Zvi , Rotstein Coleman , Lucey Joyce , Fitzpatrick John
Published: February 2007

Seventy‐nine patients who had Hickman‐Broviac (H‐B) catheters inserted over a 1‐year period were studied. There were 52 patients in the hematological group and 27 patients in the solid tumor group. Complications associated with the H‐B cathethers were infection and venous thrombosis, with infection being more common. Nine patients experienced local infection, ten had local infection with bacteremia, and 14 had severe infection, respectively. Infectious complications were more prevalent in the hematological group; 13 of the 14 severe infections were found in patients with hematological disorders. Severe infection was more common in patients with two catheters in place as compared to those with only one catheter (P < 0.05). In particular, the presence of two catheters significantly increased the risk of infection in hematological patients. The risk of infection may be reduced by using only one catheter with either a single or double lumen.
Duodenojejunostomy and stapled occlusion for distal duodenal perforation from malignant retroperitoneal tumors
Authors: Kostroff Karen M. , Turnbull Alan D. , Rotstein Lorne E. , Raaf John H.
Published: February 2007

Three patients with unresectable malignant retroperitoneal tumors that invaded and perforated the distal duodenum presented with sepsis unresponsive to antibiotics. A technique of proximal side‐to‐side duodenojejunostomy with stapled occlusion of the distal duodenum resulted in successful diversion and immediate resolution of sepsis.
Comparision of immunologic and enzymatic assay of prostatic acid phosphatase for follow‐up and assessment of clinical status of stage d prostate cancer
Authors: El‐Shirbiny Ayda , Bhargava Arvind , Beckley Sunmolu , Fitzpatrick John , Murphy Gerald P.
Published: February 2007

Prostatic acid phosphatase (PAP) was measured in 70 patients with stage D prostate cancer under different modalities of treatment. PAP was determined by radioimmunoassay (RIA), counter immunoelectrophoresis (CIEP), and enzymatic method using α‐naphthyl phosphate to compare the usefulness of the three methods in follow‐up and assessing the clinical status of stage D prostate cancer. In the regressive state (29 patients), RIA and enzymatic methods correlated well; both gave 17% of abnormal results with a mean value of 4.7 ± 4.6 and 3 ± 1.7. Also, in the progressive state (17 patients) the two methods showed similar percentages of abnormal results with a mean value of 40 ± 38 and 19 ± 17 for RIA and enzymatic method, respectively. There was greater variability in the stable group owing to the difference in the tumour load. Again the two methods correlated well regarding their diagnostic sensitivity and specificity as a parameter for assessing the clinical response. CIEP, used as a qualitative method, showed more positive than negative results and did not correlate with the clinical state. We feel that the conventional enzymatic method is adequate for follow‐up and assessing clinical state of stage D prostate cancer.
Six recent liposarcomas including largest to date
Authors: Takagi Hiroshi , Kato Kimiyuki , Yamada Eikichi , Suchi Taizan
Published: February 2007

This report describes six cases of liposarcoma. The primary sites were the retroperitoneum in three cases, the lower extremity in two cases and the jejunal mesenterium in one case. One retroperitoneum case had the heaviest liposarcoma (40 kg) that has been reported in the literature. One patient with thigh liposarcoma who developed three recurrences and underwent hemipelvectomy has been free from the disease for the past 6 1/2 years. Histologically, all three retroperitoneum cases showed well‐differentiated liposarcoma and two lower extremity cases had myxoid type liposarcoma.
Tracheal carcinoma presenting as a thyroid tumor
Authors: Zirkin Howard J. , Tovi Ferit
Published: February 2007

Direct invasion of the trachea by an aggressive tumor originating in the thyroid gland is an unusual but well‐documented phenomenon. The reverse situation, that is, a primary tracheal neoplasm invading by direct extension into the thyroid gland and presenting as a thyroid mass is apparently an even less common occurrence. A careful search of the literature has failed to reveal any recorded instances of this type of occurrence. We report a case of an adenoid cystic carcinoma arising in the trachea and invading the thyroid gland and recurrent laryngeal nerves causing vocal cord paralysis. The presentation of this lesion as a primary thyroid tumor is an unusual occurrence that serves to remind the clinician that in the differential diagnosis of thyroid masses one must include the possibilities of metastases or direct extension of a primary neoplasm from another organ.
Lateral pectoralis nerve: The need to preserve it in the modified radical mastectomy
Authors: Serra G. Elpidio , Maccarone G. Biagio , Ibarra P. Eduardo , de la Fuente Rafael
Published: February 2007

The preservation of the medial pectoralis nerve is classical and compulsory in the Patey Modified Radical Mastectomy, which innervates the clavicular and sternal insertions of the pectoralis major muscle. The lateral pectoralis nerve innervates the lower third, and the costo‐abdominal insertions of the pectoralis major muscle.

The tight relationship of this nerve with the pectoralis minor muscle makes it impossible to resect the muscle without damaging the nerve. The lesion of this nerve causes fibrosis, atrophy and shortening of the pectoralis major muscle, limitations of the shoulder movements, and a certain degree of skeletonization of the chest wall. Routine removal of the pectoralis minor muscle, as seen in Patey's type operation, with sectioning of the lateral pectoralis nerve, and the above mentioned sequela, is not recommended since it destroys the cosmetic result which is the main objective of the surgery. In naming these structures we prefer Moosman's proposal, because it is easier to remember, it adapts better to our surgical training, and it denotes course location and distribution. We encourage the preservation of the pectoralis minor muscle, and the lateral pectoralis nerve in the modified radical mastectomy, following the Scanlon's proposal in the hope of maintaining a cosmetic aspect and an appropriate base for the reconstructive surgery.
Biliary and duodenal bypass for carcinoma of the head of the pancreas
Authors: Gough Ian R. , Mumme Geoffrey
Published: February 2007

A review was undertaken of 66 patients having palliative bypass surgery for carcinoma of the head of the pancreas. A second laparotomy for relief of duodenal obstruction was necessary in six of 29 (20%) of the patients who did not have gastroenterostomy performed initially, but late gastric outlet obstruction occurred only once in 37 patients having an initial gastroenterostomy (P < 0.05). Cholecystojejunostomy failed to provide permanent biliary bypass in 14 of 53 (26%) patients, compared to successful drainage in all 13 patients having anastomosis of the common hepatic duct to the jejunum (P < 0.05). In seven patients cholecystojejunostomy was performed when the cystic duct was already obstructed by tumour. Therefore prophylactic gastrojejunostomy is recommended as a routine. The gallbladder should only be used for biliary bypass when appropriate contrast x‐rays have demonstrated the patency of the cystic duct.
Primary carcinoma of stensen's duct: Recognition and management with literature review
Authors: Frechette Claude N. , Demetris Anthony J. , Barnes E. Leon , Futrell J. William
Published: February 2007

Primary carcinoma of Stensen's duct is a rare neoplasm with only 15 cases reported in the English literature since 1927. The authors present a recent additional patient and discuss their criteria for the determination of true primary ductal lesions based upon clinical presentation, operative findings, and tumor histology. This method of selection, most particularly involving electron microscopy in the reported case, is necessary to define whether the lesion originates from the ductal epithelium. All previously reported cases were reviewed, together with the actual pathologic slides in four available cases. Only ten were retained as primary ductal lesions. Most important, this analysis clarifies the natural history of these neoplasms and reinforces a recent theory of histogenesis of salivary gland tumors. In light of these findings, a rational treatment plan can be suggested.
Renal cell carcinoma presenting as skeletal muscle mass
Authors: Alexiou G. , Papadopoulou‐Alexiou M. , Karakousis C. P.
Published: February 2007

Solitary muscle tumor, representing the first manifestation of metastatic renal cell carcinoma, is rare. A case report of a tumor mass in the left posteromedial arm, which proved to be metastatic from the right kidney, is presented. The incidence of this condition among patients presenting as a soft tissue sarcoma may be about 1%.
Primary neuroendocrine carcinoma of the skin (Merke's cell carcinoma)
Authors: Alexiou G. , Papadopoulou‐Alexiou M. , Karakousis C. P.
Published: February 2007

Primary neuroendocrine carcinoma of the skin (Merkel's cell carcinoma) is a rare tumor. Until recently 86 patients with this tumor have been described. Two cases of this tumor are presented. This neoplasm has a high propensity for lymphatic as well as hematogenous metastases. It presents as a dermal or subcutaneous nodule. Awareness of this condition may lead to earlier diagnosis and improved survival.
Carcinosarcoma of the heart
Authors: Chen Karl T. K.
Published: February 2007

A unique intracardiac tumor arising in the left atrial wall is described. The patient presented with the classical clinical features of left atrial myxoma. The resected tumor was histologically malignant and showed features of a carcinosarcoma, a tumor type which has not previously been reported to arise in the heart. Histogenetically, this tumor may represent the malignant counterpart of cardiac myxoma.
Reassessment of technical and biological factors in paranasal sinus carcinoma
Authors: Hintz Brace L. , Kagan A. Robert , Wollin Myron , Miles John , Chan Paul Y. M. , Nussbaum Herman , Rao Aroor R. , Ryoo Monica C.
Published: February 2007

Twenty‐seven patients with paranasal sinus carcinoma were analyzed. Local control with radiation alone was poor, with most patients failing centrally within the primary site. With preoperative radiation local control is 60%. Previous reports have emphasized failure at superior sites—particularly the orbit. The pattern of local failure in our series is predominantly various medial sites inclusive of intact or exenterated orbit. The surgically nonremovable medial structures are best encompassed by a three‐field radiotherapy technique (weighted anterior and two laterals).
Malignant feminizing leydig cell tumor
Authors: Shapiro Charles M. , Sankovitch Anatole , Yoon Woo J.
Published: February 2007

A patient with a feminizing malignant Leydig cell tumor is presented. Hormonal assays revealed increased production of prolactin, estradial, and total estrogens. Eleven years after the onset of his disease he remains clinically well.
Scrotal calcinosis: Calcification of epidermal cysts
Authors: Sarma Deba P. , Weilbaecher Thomas G.
Published: February 2007

The so‐called idiopathic scrotal calcinosis does not appear to be idiopathic, but rather a process of dystrophic calcification of epidermal cysts. We report a case that would be otherwise called “idiopathic” where we found squamous epithelial lining around the calcified masses. Literature is reviewed in support of the view that the calcified scrotal nodules are related to epidermal cysts.
Chemotherapy trials in malignant pheochromocytoma: Report of two patients and review of the literature
Authors: Bukowski R. M. , Vidt Donald G.
Published: February 2007

Two patients with metastatic pheochromocytoma received chemotherapy with 5‐fluorouracil, cyclophosphamide, and streptozotocin. A biochemical response occurred in one instance. A review of the literature and the results in the reported patients indicate cyclophosphamide and/or streptozotocin may have activity in this neoplasm.
Intraoral melanoacanthoma
Authors: Frey Vincent M. , Lambert W. Clark , Seldin R. David , Schneider Lawrence C. , Mesa Mayra L.
Published: February 2007

A 39‐year‐old black woman noted a pigmented lesion on her right buccal mucosa of which she had been previously unaware. Physical examination revealed a 2.0 × 1.8‐cm uniformly pigmented, macular to slightly plaque‐like, symmetrically folded, indented lesion. Histologic examination revealed a hyperplastic mucous membrane containing numerous dendritic melanocytes at all levels. No pleomorphism or cytological atypia was recognized and no fibrosis was present in the corium. The case was diagnosed as “melanoacanthoma”.
Metastasizing basal cell carcinoma developing in a gunshot wound in a black man
Authors: Lambert W. Clark , Kasznica John , Chung Haingsub R. , Moore Dorothy
Published: February 2007

Both basal cell carcinomas that arise in blacks and those that metastasize are rare, and development of this tumor is an uncommon, late complication of trauma. We report a case of a 70‐year‐old black man with a basal cell carcinoma arising in a gunshot wound in a shoulder and metastasizing to axillary lymph nodes. Histologically, the tumor was of the metatypical type.
Peroxidase antiperoxidase versus specific red cell adherence in detection of O (H) antigen in bladder cancer: A blind study
Authors: Javadpour N. , Vafrier J. , Worsham G. F. , O'connel K.
Published: February 2007

We have previously demonstrated that the presence or absence of ABO(H) cell surface antigens correlated with stage, grade, and prognosis of patients with bladder cancer. However, because of the weak antigenecity of 0(H), certain investigators have reported a high rate of false‐negative results utilizing specific red cell adherence (SRCA) test of Davidsohn. Since approximately 45% of the population is blood group 0(H), this high rate of false‐negative result renders the test unreliable in an ordinary laboratory. The present study is comparing the results of SRCA to that of peroxidase antiperoxidase (PAP) technique in a double‐blind fashion in 29 patients with bladder cancer having 0(H) blood group. In terms of grade, stage, frequency of recurrent tumor, and quality of slides, the results of PAP is superior over SRCA. Furthermore, the convenience, permanence, and ready availability of PAP will enhance the utility of this test in a conventional histopathologic laboratory with a high rate of accuracy and reproducibility.
Hepatic artery ligation and chemotherapeutic infusion in the treatment of hepatic malignancy
Authors: Al‐Jurf Adel S. , Jochimsen Peter R. , Shirazi Siroos S. , Zike Wilbur L. , Urdaneta Luis F.
Published: February 2007

This report reviews the results of treatment of hepatic malignancies by intra‐arterial infusional chemotherapy and hepatic artery ligation. Seventy‐nine patients with liver metastases or primary hepatomas were treated by this technique between the years 1970 and 1982. The majority of patients had metastatic disease from colon and rectal cancers. The median and mean survivals in the total group was 10 and 14 months, respectively (including operative deaths). Patients with metastatic disease from colon and rectal cancers had better survival than those with metastases from other primaries. Patients with synchronous liver malignancy had better survival than those with metachronous disease. Length of survival correlated positively with the duration of chemotherapeutic infusions, the latter being frequently (in 42% of patients) interrupted because of catheter complications. A new technique utilizing implantable pumps can be expected to further improve the results by reducing catheter malfunction and prolonging treatment courses.
A technique for isolated hyperthermic liver perfusion
Authors: Quebbeman Edward J. , Skibba Joseph L. , Petroff Robert J.
Published: February 2007

Hyperthermia, either alone or combined with chemotherapy, has been shown to be effective in treating cancer. Because some investigators believe that regional hyperthermia may be more effective than whole body hyperthermia, we developed a technique to heat only the liver to 42‐43 degrees for 4 hr. The procedure was adapted from a previously described animal model and was performed in four humans. Vascular isolation of the liver was accomplished by cannulating the hepatic artery, the portal vein, and the inferior vena cava followed by occluding the suprahepatic vena cava and the liver was then perfused with blood and nutrients from an oxygenated reservoir. Preliminary results show radiologic and histologic evidence of tumor necrosis or cessation of tumor growth in three of the patients. We believe this technique is safe enough for clinical experimental use and deserves further investigation.
The giant apocrine hidrocystoma
Authors: Lambert W. Clark , Wiener Bruce Dennis , Schwartz Robert Allen , Quillen Carl G. , Giampapa Vincent C.
Published: February 2007

We report a patient with a large apocrine hidrocystoma. These tumors are almost always under 10 mm in diameter. In this 40‐year‐old man the tumor measured 20 mm. Apocrine hidrocystoma must be considered when evaluating a patient with a large cystic lesion of the face. Surgical management is similar to that of other benign cystic lesions of this region.
Evaluation of leukocyte adherence inhibition (LAI) test in primary and secondary hepatic malignancies
Authors: Tantry B. V. , Jain A. K. , Gupta Saroj , Gupta J. P.
Published: February 2007

Leukocyte adherence inhibition (LAI) has been demonstrated to be a simple, rapid, and reliable technique in the diagnosis of various malignancies including hepatocellular carcinoma. The LAI test was carried out employing modified tube LAI technique in patients with primary hepatocellular carcinoma (HCC) and secondary carcinomas of liver. Positive LAI response to HCC antigen was obtained in all six (100%) cases of hepatocellular carcinoma tested. None of the control cases, which included 8 healthy subjects and 16 cases of benign liver diseases, gave positive LAI response. Two out of 19 cases of secondary carcinoma gave a positive LAI reaction to HCC antigen. In secondary carcinomas, 19 out of 21 cases (90.48%) gave positive LAI reaction to secondary adenocarcinoma antigen. There were two false positives in controls (1 each of cirrhosis and amebic liver abscess), and 1 out of 8 cases of HCC also gave positive response to secondary carcinoma antigen. Thus, LAI test was found to be useful in the diagnosis of hepatic malignancies.