bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing the Anxiolytic and Relaxation Effects of Cinnamomum camphora Essential Oil in University Students: A Comparative Study of EEG, Physiological Measures, and Psychological Responses
Authors: Gong Xiangfei , Yang Yujun , Xu Tong , Yao Dongsheng , Lin Shengyu , Chang Weiyin
Published: July 2024

Background

Cinnamomum camphora is a commercially important tree species in China, and it’s also a common native tree in the forests of southern China. However, literature on the impact of Cinnamomum camphora essential oil (CCEO) on human psychophysiological activity is scarce. Hence, the primary objective of this study was to examine the effect of exposure to CCEO on the functioning of the human autonomic nervous system, electroencephalographic (EEG) activity, and emotional state.

Methods

Forty-three healthy university students participated. The data collected included heart rate (HR), blood pressure (BP), pulse rate, blood oxygen saturation (SpO2), electroencephalographic (EEG) activity, and the results of the Profile of Mood States (POMS) test.

Results

A drop in diastolic pressure (DBP) and pulse rate was also noticed after participants inhaled CCEO. Furthermore, EEG studies have demonstrated notable reductions in absolute beta (AB), absolute gamma (AG), absolute high beta (AHB), and relative gamma (RG) power spectra during exposure to CCEO. Conversely, the relative theta (RT) and power spectra values showed a significant increase. Additionally, the finding from POMS indicated that the fragrance evoked positive emotions and suppressed negative feelings.

Conclusion

The results suggest that exposure to CCEO may promote mental and physical relaxation, facilitate cognitive processes such as memory and attention, and enhance mood states.
Chains of extraction: shifting bioeconomies in India and East Africa
Authors: Gondouin Johanna , Eriksson Åsa , Thapar-Björkert Suruchi
Published: July 2024

Since the early 2000s, India has been a world leading hub for cross border reproductive treatments, in particular surrogacy, with the nation positioning itself as the “mother destination” for transnational commercial surrogacy, offering “First world services at Third world prices”. State policies, lack of legal regulation, state of the art medical infrastructure and a steady supply of women ready to take on the role as surrogate mothers against meager remuneration have been key factors behind the Indian success story. Yet, a gradual process of regulation in recent years, culminating in the introduction of the Surrogacy (Regulation) Bill 2020, has forced the industry to reinvent itself in order to maintain its role as a market leader in a booming global bioeconomy. This article takes the 2020 bill as a starting point for an exploration of the key trajectories that the Indian reproductive industry has taken since. This includes moving into new market segments, such as the unregulated practice of oocyte donation, and expanding globally into new geo-political contexts. Through these practices, India has successfully rebranded itself as a world leading “pre-conception assemblage hub” where embryos are assembled and implanted into surrogates who carry their pregnancies to term in countries with no protective legislation. The article begins to map the emerging links between the reproductive industry in India and East Africa - where diasporic networks are mobilized in the creation of new reproductive markets, dominated by Indian IVF providers. In particular, we discuss the current expansion in Kenya, which we situate against the backdrop of the colonial entanglements between the two countries. While the ART industry in Kenya is still young, we suggest that these emerging developments illuminate the effect of the ban on commercial surrogacy in India, which appears to have resulted in a partial relocation to countries that lack regulation, shifting the precarious conditions of surrogates in India to other women, elsewhere, in ways that rearticulate colonial racial hierarchies and migration patterns.
Investigating the workforce capacity and needs for animal disease surveillance and outbreak investigation: a mixed-methods study of veterinary services in Vietnam
Authors: Auplish Aashima , Tra Vu Thi Thu , Pham Duc Phuc , Green Alexandra C. , Tiwari Harish , Housen Tambri , Stevenson Mark , Dhand Navneet
Published: July 2024

The need for strengthening national capacities for disease prevention, preparedness, and response is increasingly becoming urgent. Central to this is strengthening existing systems and workforce capacity for disease surveillance and disease outbreak response. This study aimed to evaluate the national capacity and needs of veterinary services in Vietnam in animal disease surveillance and outbreak investigation skills. A cross-sectional, convergent, mixed-methods study was conducted between November 2020 and April 2021. An online questionnaire was administered to government field veterinarians, followed by descriptive and multivariable analyses to understand field capacity, specifically levels of experience in outbreak investigation and animal health surveillance. Semi-structured interviews were conducted with various stakeholders in veterinary services and interview transcripts were coded and thematically analyzed. Qualitative results were used to contextualize quantitative findings from the survey. Overall, 178 field veterinary staff completed the online survey, and 25 stakeholders were interviewed. Eighty percent of respondents reported a high priority for further training in both animal disease surveillance and outbreak investigation. Training and competence were more limited at the district and commune levels, highlighting a gap in capacity at the subnational level. Reasons included a lack of in-depth training opportunities, limited access to resources and high staff turnover. Respondents who completed postgraduate qualifications in epidemiology or Field Epidemiology Training Programs were more likely to have higher levels of experience in animal health surveillance and outbreak investigation. This study identified gaps in knowledge and adoption of practices most often related to local-level or less experienced veterinary staff with limited training opportunities in epidemiology. Findings inform the prioritization of training and planning activities to further enhance the national capacity of veterinary services in Vietnam. Underlying explanations for existing gaps in capacity include inequities in skill development and training opportunities across levels of veterinary staff, gaps in the chain of command and unequal funding across provinces.
Development of a UPLC-MS/MS method for quantifying KPT-335 (Verdinexor) in feline plasma for a study of PK
Authors: Yang Yuxin , Qiu Jicheng , Kong Jingyuan , Cao Yuying , Liu Yu , Chen Sumeng , Wen Zeyu , Sun Feifei , Cao Xingyuan
Published: July 2024

KPT-335 (Verdinexor) is a novel SINE that potently inhibits the nucleoprotein Exportin 1 (XPO1/CRM1) of tumor cell lines and reduces the replication level of the influenza virus. KPT-335 is mainly used for the treatment of canine tumors. Drugs for the effective treatment of feline tumors are currently unavailable in China. KPT-335 may have potential in the treatment of cat tumors. However, the effects of KPT-335 in cats are unreported, and no relevant methodology has been established for pharmacokinetic studies. In this study, a UPLC-MS/MS method was developed to determine KPT-335 concentrations in cat plasma, followed by pharmacokinetic studies. Briefly, plasma proteins are precipitated with acetonitrile, and the supernatant was collected for detection after centrifugation. The linearity for KPT-335 in cat plasma was in the range of 5–1,000 ng/mL. Satisfactory accuracy and precision were obtained. The intra-day accuracy was between −4.10% and 10.48%, the precision was ≤4.65%; the inter-day accuracy was between −0.11% and 8.09%, and the precision was ≤5.85%. Intra-day and inter-day accuracy and precision were within regulatory limits. The results of preliminary pharmacokinetic studies were as follows: Tmax was 1.46 ± 0.51 h; Cmax was 239.54 ± 190.60 ng·mL−1; T1/2 was 5.16 ± 2.30 h; AUC0-t was 1439.85 ± 964.64 ng·mL−1·h. The AUC0-∞ was 1589.82 ± 1003.75 ng·mL−1·h. The purpose of this study was to develop a rapid and simple UPLC-MS/MS method to detect KPT-335 concentration in cat plasma and to conduct preliminary pharmacokinetic studies to support the future application of KPT-335 in felines.
Treatment Responses in Histologic Versus Molecular Diagnoses of Lung Rejection
Authors: Zajacova A. , Mackova M. , Halloran K. , Gauthier P. , Balko J. , Guney M. , Rakita D. , Svorcova M. , Kolarik J. , Vachtenheim J. , Pozniak J. , Simonek J. , Fila L. , Lischke R. , Halloran P. F. , Havlin J.
Published: July 2024

Histologic evaluation of allograft biopsies after lung transplantation has several limitations, suggesting that molecular assessment using tissue transcriptomics could improve biopsy interpretation. This single-center, retrospective cohort study evaluated discrepancies between the histology of transbronchial biopsies (TBBs) with no rejection (NR) and T-cell mediated rejection (TCMR) by molecular diagnosis. The accuracy of diagnosis was assessed based on response to treatment. 54 TBBs from Prague Lung Transplant Program obtained between December 2015 and January 2020 were included. Patients with acute cellular rejection (ACR) grade ≥ 1 by histology received anti-rejection treatment. Response to therapy was defined as an increase in FEV1 of ≥ 10% 4 weeks post-biopsy compared to the pre-biopsy value. Among the 54 analyzed TBBs, 25 (46%) were concordant with histology, while 29 (54%) showed discrepancies. ACR grade 0 was found in 12 TBBs (22%) and grade A1 ≥ 1 in 42 TBBs (78%). Treatment response was present in 14% in the NR group and in 50% in the TCMR group (p = 0.024). Our findings suggest that low-grade acute cellular rejection is less likely to be associated with molecular TCMR, which might better identify lung transplant recipients who benefit from therapy.
Biologiczne uwarunkowania modyfikacji wymowy polskich sybilantów dziąsłowo-palatalnych przez młodych dorosłych
Authors: Ciecierska-Zajdel Beata
Published: July 2024

The author studied biological determinants of the tendency to modify the palatal pronunciation of sibilants [ɕ], [ʑ], [t͡ɕ], [dຏʑ] observable in young adults. The research group included 30 students, who exhibited varying levels of correct phonetic realisations of these consonants. The subjects underwent an examination that assessed their anatomical conditions, the functioning of their articulatory apparatus, the correct course of primary functions, the perceptual determinants, and the accuracy of the articulation of other Polish speech sounds. The study was quantitative. The results of the study were juxtaposed against the total number of the non-normatively realised sibilants, and subsequently analysed statistically. It turned out that there is a clear connection between the anatomical and funcƟtional factors, and the number of modified consonants: [ɕ], [ʑ], [t͡ɕ], [dຏʑ]. Therefore, the distortion of the palatal sibilants cannot be treated only as a socially or culturally conditioned pronunciation mannerism
The Impact of Knowledge Management and Organizational Learning Promotion in Small and Medium Enterprises on the Implementation of Industry 4.0 and Competitiveness
Authors: Cheng Chun-Hung , Li Meng-Hua , Tang Bau-Jen , Cheng Yea-Rong
Published: July 2024

The transformation and upgrading of small- and medium-sized enterprises (SMEs) need to align with global industrial development trends and can further assist SMEs in sustainable operation. In recent years, major industrial countries, such as Germany, China, and the United States, have promoted policies like Industry 4.0 or advanced manufacturing as part of their national manufacturing transformation strategies. In contrast, how SMEs follow these global industrial development trends and effectively apply new technologies hinges on internal knowledge management and organizational learning. To achieve the benefits of new technology implementation, enterprises must establish an effective knowledge management and organizational learning mechanism and promotion practices. The Taiwanese government has also adopted Industry 4.0 as an essential tool for assisting the transformation and upgrading of SMEs. Therefore, this study surveyed 129 SMEs in the Taiwanese metal industry, using a one-way ANOVA, Pearson correlation analysis, and simple regression analysis to explore the impact of the internal promotion of knowledge management and organizational learning on the introduction of Industry 4.0 and the enhancement in competitiveness. The results of this study indicate that the promotion of knowledge management and organizational learning contributes to the effective adoption of Industry 4.0 and the enhancement in competitiveness, showing significant correlations between these factors. Thus, the findings can serve as a reference for other partner countries.
Analysis and Evaluation of Fault Propagation Behavior in Integrated Avionics Systems Considering Cascading Failures
Authors: Dong Lei , Peng Bo , Chen Xi , Liu Jiachen
Published: July 2024

As the synthesis, modularization, and integration of avionics systems increase, the interconnections between systems and equipment within subsystems become increasingly complex, posing risks to the safety and reliability of the integrated avionics system. To address the risk of fault propagation due to functional cascade failures in integrated avionics systems, this paper proposes a discrete dynamic fault propagation analysis method, which was applied to an all-electric braking system to assess its feasibility. First, the architectural features of the Distributed Integrated Modular Avionics system are summarized. Subsequently, the constructed system layer model is described, establishing the function–resource hierarchical architecture. Subsequently, the behavior of cascading failure propagation in discrete dynamic systems is analyzed by integrating the cascading failure analysis method from SAE ARP 4761A and considering the coupling characteristics between system properties and functions comprehensively. This approach facilitates the development of a cascading failure propagation model for DIMA based on discrete dynamic systems. Finally, by using the all-electric braking system under DIMA architecture as a case study, key Core Processing Modules and failure-prone functions are identified. The findings reveal that within this system, CPM2 and CPM6 are particularly susceptible to failure propagation, and the automatic brake function is notably vulnerable. Data show that the system’s failure rate escalates markedly after 2×104 h of operation. Performing maintenance before reaching this threshold can further mitigate risks. This practice aligns with current international aircraft maintenance time regulations. The method proposed in this paper can be applied early in the allocation of DIMA resources to enhance security and support DIMA design.
Numerical Analysis of the Water Entry Process of the Cabin Structure of the Trans-Domain Morphing Aircraft Considering Structural Deformation
Authors: Zhang Yu , He Ziyi , Wang Chen , Hu Qi , Dong Songwen , Shen Xing , Zhang Jun , Wang Taoxi
Published: July 2024

During the water entry process of a trans-domain morphing aircraft, significant impact forces are generated when the aircraft hits the water surface, which will potentially cause the deformation of the cabin structure and might damage the structure or onboard devices. Thus, it is necessary to investigate the water entry process of the cabin structure. This paper analyses changes in fluid loads and the corresponding structural responses during the water entry process. Firstly, the numerical model is established for the water entry process and the modeling method is validated by comparing the results to the experimental data. An empirical formula is developed to correlate the impact loads with the water entry velocities. Then, fluid–structure interaction analysis of the water entry process is performed using a two-way coupling approach. The relationship between structural deformation and the water entry process is then investigated. The results are compared with those without considering the structural deformation. The empirical formula is then modified to reflect the effects of the deformation. The results show that structural deformation will disperse the impact load, which represents different responses compared to the rigid cabin structure.