bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a Composite from TPS–EVOH–SBR Reinforced with Coconut Fiber
Authors: Meráz-Rivera Jonathan , Cruz-Rivero Lidilia , Méndez-Hernández María Leonor , Rivera-Armenta José Luis , Angeles-Herrera Daniel , Ramírez-López Citlally
Published: September 2020

The aim of this research is to obtain a composite made of coconut fiber, thermoplastic starch (TPS), ethylene vinyl alcohol (EVOH), and styrene–butadiene copolymer (SBR), achieving the most significant criteria/attribute determined by users. The tools used were quality function deployment (QFD) and the theory of inventive problem solving (TRIZ). The end result indicated that the quality requirement and most representative attribute for users is the toxicity of the material. Four mixtures were made with different percentages of coconut fiber, TPS–EVOH, and SBR, subjecting them to Fourier transform infrared spectroscopy (FTIR), dynamic mechanical analysis (DMA), and thermogravimetric analysis (TGA). The material obtained complies with the requirements of the Food and Drug Administration (FDA) regarding the nontoxicity of synthetic materials (EVOH and SB) to be used in contact with food (packaging and packaging). The spectra IR of the presence of monomers such as methacrylic acid, 2-hydroxyethyl acrylate, itaconic acid, among others, was not detected due to the humidity of the material. On the other hand, the DMA graphs showed that the mixtures achieved high storage modules (from 1500 to 3000 MPa) at temperatures from −90 to −70 °C, and the TGA thermogram showed that the last material to degrade was SBR at temperatures from 400 to 500 °C.
Preparing Society for Automated Vehicles: Perceptions of the Importance and Urgency of Emerging Issues of Governance, Regulations, and Wider Impacts
Authors: Chen Su-Yen , Kuo Hsin-Yu , Lee Chiachun
Published: September 2020

This study explores the overall picture of how people perceive the importance level and urgency level regarding issues associated with automated vehicles, by sorting out ten issues, developing a questionnaire with 66 measurement items, and investigating how Artificial Intelligence (AI) experts and Computer Science (CS)/Electrical Engineering (EE) majors assessed these issues. The findings suggest that AI experts in Taiwan believed that the top five issues for preparing a society for autonomous vehicles (AVs) should include (1) data privacy and cybersecurity, (2) regulation considerations, (3) infrastructure, (4) governance, and (5) public acceptance. On the other hand, for their student counterparts, the results (1) demonstrate a somewhat different order from the third to the fifth place, (2) show an attention-focused profile on the issue of cybersecurity and data privacy, and (3) indicate that gender and a few wider-impact variables (technology innovation, infrastructure) are significant predictors for the assessment on the importance level of AVs, while some wider-impact variables (technology innovation, governance, economic benefits, infrastructure), which are positively associated, as well as concerns variables (cybersecurity and data privacy, regulations), which are negatively associated, could be predictors for the urgency level of AVs. Suggestions for future research and policymakers are provided.
On-Site Experience Effect on Stakeholders’ Preferences of Forest Management
Authors: Li Xiaoshu , Stainback G. Andrew
Published: September 2020

An understanding of how public preferences vary among different stakeholders toward forest management policies would be helpful in the forest policy design and administration process. In this study, we investigate the preferences toward forest management policies of three stakeholder groups-woodlot owners, environmentalists, and the general public. We used a stated-preference survey to elicit information about stakeholder preferences for forest management practices at Holt Research Forest in Maine. The survey was administered to each group both before and after an on-site experience at the forest. We specifically investigated how information and experience acquired through the on-site experience would influence the preferences of each group. We also conducted a latent class analysis to further explore the preference heterogeneity among survey participants. The results show differences in preferences for forest management policies between stakeholders with the preferences of woodlot owners differing substantially from environmentalists and the general public both before and after the on-site experience. The on-site experience did not have a substantial impact on woodlot owners. In contrast, it increased the consistency of choice decisions among environmentalists and the public.
Quality as Driver for Sustainable Construction—Holistic Quality Model and Assessment
Authors: Zhang Li , Balangé Laura , Braun Kathrin , Di Bari Roberta , Horn Rafael , Hos Deniz , Kropp Cordula , Leistner Philip , Schwieger Volker
Published: September 2020

Facing rising building demands due to a fast-growing world population and significant environmental challenges at the same time, the building sector urgently requires innovation. The Cluster of Excellence Integrative Computational Design and Construction for Architecture at the University of Stuttgart tackles these challenges through a Co-Design approach for integrating computational design and engineering and robotic construction. Within this research framework, a Holistic Quality Model is developed to ensure the technical, environmental, and social quality of Co-Design processes and products. Up to now, quality models that consider and integrate all these three aspects throughout the life cycle of buildings are still missing. The article outlines the concept of holistic quality assessment based on a Holistic Quality Model for sustainable construction. A key mechanism for sustainable quality assessment in the Holistic Quality Model is the definition of control and decision points in the construction process where critical decisions are made that will affect the quality of the building throughout its entire life-cycle. Firstly, subject-specific quality concepts are defined and their interrelations are conceptualized. Subsequently, these interrelations and their effects on the overall Co-Design construction processes and products are explained using the example of the semi-robotic production of concrete slabs. Examples for control and decision points are given as well. The outline presented here serves as a basis for further advancing and concretizing the Holistic Quality Model and its applications in Co-Design for a functioning, liveable, and sustainable high-quality construction and building culture.
Detecting Weak Signals of the Future: A System Implementation Based on Text Mining and Natural Language Processing
Authors: Griol-Barres Israel , Milla Sergio , Cebrián Antonio , Fan Huaan , Millet Jose
Published: September 2020

Organizations, companies and start-ups need to cope with constant changes on the market which are difficult to predict. Therefore, the development of new systems to detect significant future changes is vital to make correct decisions in an organization and to discover new opportunities. A system based on business intelligence techniques is proposed to detect weak signals, that are related to future transcendental changes. While most known solutions are based on the use of structured data, the proposed system quantitatively detects these signals using heterogeneous and unstructured information from scientific, journalistic and social sources, applying text mining to analyze the documents and natural language processing to extract accurate results. The main contributions are that the system has been designed for any field, using different input datasets of documents, and with an automatic classification of categories for the detected keywords. In this research paper, results from the future of remote sensors are presented. Remote sensing services are providing new applications in observation and analysis of information remotely. This market is projected to witness a significant growth due to the increasing demand for services in commercial and defense industries. The system has obtained promising results, evaluated with two different methodologies, to help experts in the decision-making process and to discover new trends and opportunities.
Ranking Potential Renewable Energy Systems to Power On-Farm Fertilizer Production
Authors: Mostafaeipour Ali , Sadeghi Sedeh Ali , Chowdhury Shahariar , Techato Kuaanan
Published: September 2020

Farmers across the world have long used chemical fertilizers to achieve higher production outputs. One of the basic inputs for the production of nitrogen fertilizer is fossil fuel, which is not only finite but also has tangible impacts on the environment. This study aims to determine the most suitable renewable energy resource (RER) for the production of fertilizer in Iranian farmlands. The resources considered in this study were photovoltaic energy, biomass energy, wind energy, and solar thermal energy. This assessment was carried out in terms of six general criteria derived from a PESTEL (Political, Economic, Socio-cultural, Technological, Environmental and Legal) analysis, and thus 20 sub-criteria were obtained with the help of experts. The criteria were weighted using the Fuzzy AHP (Analytic Hierarchy Process) method. Because of the use of criteria with crisp, fuzzy, and interval-type values, the ranking was performed using the extended TODIM (an acronym in Portuguese of interactive and multi-criteria decision-making) method. A sensitivity analysis was performed to determine the effects of the sub-criteria on the results. The results showed that the technological criterion is the most important measure for this assessment, and that photovoltaic energy and wind energy are the top two options for powering chemical fertilizer production in Iranian farmlands.
Enhancing Flood Resilience and Climate Adaptation: The State of the Art and New Directions for Spatial Planning
Authors: Meng Meng , Dabrowski Marcin , Stead Dominic
Published: September 2020

The need to respond to increasing flood risk, climate change, and rapid urban development has shaped innovative policies and practices of spatial planning in many countries over recent decades. As an instrumental–technical intervention, planning is mainly used to improve the physical environment (through concepts such as regulating waterproof facades of architecture, setting buffering zones, and designing green–blue corridors). However, the implementation of the proposed physical interventions is often challenging and necessitates assistance from practices such as climate assessment, policy disciplines, civil societies, and economic resources. These extensive perspectives have spawned many new research domains in the realm of spatial planning. This paper provides a review of the recent developments in flood resilience, risk management, and climate adaptation; based on this, it positions planning research and practice within these works of literature. Four clusters of thought are identified, mainly in the European and American scholarship of the last two decades. They are environmental concerns, disaster management concerns, socio-economic concerns, and institutional concerns. Current planning research concentrates on disaster management in the underlying belief that planning is functionally efficient. The attention to environmental concerns, socio-economic concerns, and institutional concerns of planning research remains insufficient but has been growing. This, in turn, enlarges the scope of planning research and indicates future directions for study. These new concerns relate to spatial planning’s ability to operate effectively in a multi-sectoral setting, despite limited resources and in the face of uncertain risk.
A Triple-Helix Approach for the Assessment of Hyperloop Potential in Europe
Authors: Gkoumas Konstantinos , Christou Michalis
Published: September 2020

Hyperloop is a proposed high-speed surface mode of passenger and freight transport that has gained much visibility in recent years. Since its introduction in modern form in 2013, progress on Hyperloop has been thriving, with several companies involved in research and development of Hyperloop systems and subsystems. Some of them have planned testing tracks in Europe, anticipating what could be the start of commercial routes. Nevertheless, there are concerns that need to be addressed regarding the safety and serviceability performance, and further steps are necessary for the standardization and certification of the system. This study leverages the state of play of Hyperloop development, identifies issues and challenges from a European perspective, and provides policy insights towards testing and commercialization. To this end, it follows a two-tier approach that (i) addresses safety concerns related to the implementation of Hyperloop as a key enabler of the proposed technology and (ii) analyses Hyperloop technology developments using a triple-helix innovation approach, using a structured methodology based on consolidated data sources (i.e., the Scopus database of peer-reviewed literature and the Patstat patent database). The performed analyses highlight the significant amount of research and patent activity on several aspects of Hyperloop, while the mapping of activities carried out by industry in Europe, as well as from European Services, highlights the progress made towards the future Hyperloop implementation in Europe. Altogether, these findings provide factual information regarding the necessary research, policy, and industry steps taken so far that can help bring Hyperloop into the market. To the authors’ knowledge this represents a very systematic and extensive literature review on Hyperloop’s scientific and technological developments.
Geomorphological and Geochronological Analysis Applied to the Quaternary Landscape Evolution of the Yeltes River (Salamanca, Spain)
Authors: Martín-Martín Iván , Silva Pablo-Gabriel , Martínez-Graña Antonio , Elez Javier
Published: September 2020

This paper aims to study the Quaternary geomorphological evolution of the Yeltes river-valley (Duero Basin, Central Spain) primarily based on the study of the Late Neogene piedmont dissected by the river and its Quaternary terrace sequence, since fluvial terraces are excellent archives to study the landscape and climate evolution during this period. Detailed geomorphological mapping implemented in GIS-based digital elevation models was used to the further applications of existing fluvial chronofunctions (relative terrace height-age transfer functions) to establish a numerical geochronology to the sequence of fluvial terraces in the zone. The obtained theoretical ages points to an onset of fluvial incision in the zone after 2.0–2.5 Myr ago, with the dissection of the “Raña surface” (a Gelasian alluvial piedmont widely developed in Central Spain). The obtained terrace ages coincide, in most cases, with warm isotopic stages (MIS) or mainly with the transit of cold to warm MIS. Additionally, this study suggests that the full connectivity of the Yeltes drainage (Ciudad Rodrigo Basin) with the Atlantic drainage was not completely effective until MIS 9 (c. 0.29 Myr). The new reported data allows for the exploration of the timing and processes involved in the capture of inland sedimentary basins (Ciudad Rodrigo, Duero basins) by the Atlantic drainage during the early Quaternary.
Does the School Really Support My Child? SOFIA: An Assessment Tool for Families of Children with SEN in Spain
Authors: Sánchez-Pujalte Laura , Gómez-Domínguez María Teresa , Soto-Rubio Ana , Navarro-Mateu Diego
Published: September 2020

The integration of the family in educating their children allows for the optimization of educational intervention. Despite its relevance, there is not much research aimed at collecting the voice of the families of students with Special Educational Needs (SEN) about their relationship with the school system. The present study aims to develop and validate a questionnaire of the family perception of the support received from the educational system, the Satisfaction of Family in Inclusive Education Assessment (SOFIA) Questionnaire, conformed of 26 indicators. Analyses of the psychometric properties of the instrument support that they are good for use in this area. Specifically, exploratory and confirmatory factor analyses support the internal structure of the instrument (confirmatory factorial analysis (CFA) = SBχ2 = 607.11, p < 0.001; χ2/df = 2.07; Comparative Adjustment Index (IFC) = 0.902; Incremental Adjustment Index (IFI) = 0.903; the root mean square error approximation (RMSEA) = 0.071) in the same way, all dimension showed adequate reliability (Cronbach’s alpha ranged from 0.91 to 0.94; CR ranged from 0.91 to 0.95). The Average Variance Extracted (AVE) results also showed adequate results (0.55 to 0.68). Our research results indicate that the SOFIA Questionnaire’s psychometric properties are adequate for the Spanish context. The SOFIA Questionnaire is presented as a valid and reliable instrument to collect the families’ perception of the support they receive from the educational system.
Environmental Education, an Essential Instrument to Implement the Sustainable Development Goals in the University Context
Authors: Esteban Ibáñez Macarena , Lucena Cid Isabel Victoria , Amador Muñoz Luis Vicente , Mateos Claros Francisco
Published: September 2020

The objective of this research is the analysis of sustainable development’s incorporation of the Sustainable Development Goals (SDGs) in the university from the environmental education approach. The study includes the necessary strategy to implement environmental contents, as well as the training of individuals to act with environmental responsibility. The descriptive, cross-sectional and quantitative methodology was used to create a questionnaire for university students. Then, we gathered data to achieve the goals proposed in this research: interpret the variations in environmental knowledge and behavior, and understand the conceptual aspects underlying in the students’ features, paying attention to the differences between men and women. The results show that many of the students have previous concepts about the environment, and they consider that environmental education is required to solve environmental issues. Finally, a training proposal is presented to introduce the topics of the SDGs and environmental education in the university.
Comparison of Long-Run Net Returns of Conventional and Organic Crop Rotations
Authors: Langemeier Michael R. , Fang Xiaoyi , O’Donnell Michael
Published: September 2020

This study compares the long-run net returns to land of conventional corn/soybean and corn/soybean/wheat crop rotations to that of an organic corn/soybean/wheat crop rotation. The net returns to land for the organic crop rotation were found to be approximately $68 and $74 per acre higher than those of the conventional corn/soybean and conventional corn/soybean/wheat crop rotations, respectively. Average net return estimates are sensitive to price, yield, and cost assumptions. Organic crop prices would have to drop more than 17.8 percent and organic crop yields would have to drop more than 16.8 percent before the conventional corn/soybean crop rotation was more profitable than the organic corn/soybean/wheat crop rotation. These percentage changes are relatively small compared to the historical relationships between organic and conventional crop prices and yields. A risk model was used to examine the trade-off between expected net returns and downside risk. Converting even a small proportion of acreage to an organic corn/soybean/wheat crop rotation improves net returns and reduces downside risk compared to only utilizing conventional crop rotations.
Study on the Similarity of the Parameters of Biomass and Solid Waste Fuel Combustion for the Needs of Thermal Power Engineering
Authors: Jaworski Tomasz J. , Kajda-Szcześniak Małgorzata
Published: September 2020

The topic raised in this paper concerns an important aspect regarding the possibilities of the combustion and co-combustion of biomass substrates (energetic willow/sewage sludge), in light of the renewable energy source (RES) regulations, with fuel from waste defined here as RDF. Particular interest in these fuels and their mixtures results from a search by the thermal power engineering sector for fuels whose combustion will be associated with benefits, e.g., the acquisition of energy origin licenses, availability and lower cost of obtaining fuel (RDF), as well as moderate investment contributions using the existing base of coal grate boilers. This article indicates the possible variants of the combustion and co-combustion of the abovementioned fuels, referring to the use of technical and technological capabilities of coal grate furnaces. It was possible by comparing the mechanical and thermal load of grates, as well as so-called indicators for the quantitative assessment of combustion (i.e., ignition rate and mass loss rate). The result of the combustion of the fuel as above in a laboratory-scale furnace (samples weighing up to 1 kg), as well as their thermogravimetric analysis, indicates a great similarity of the mass loss curve, temperature profiles and combustion phases, as well as indicators of a quantitative assessment in the process of biomass and RDF oxidation. The obtained results of the mechanical and thermal load capacity of the grates constitute the basis for further analyses of fuel conversion, without the risk of thermal and/or mechanical grate overload. Relying on the research of the indicators for the quantitative assessment of combustion, it was found that the combustion process of the tested fuels could be carried out while maintaining the quality of burning the fuel layer. Based on the conducted research, it can be assumed that it is possible to replace coal fuels with biomass, RDF fuel, sewage sludge using coal furnaces for their combustion, which means a hybrid nature of the furnace due to the type of fuel.
The Influence of Religion on Sustainable Consumption: A Systematic Review and Future Research Agenda
Authors: Orellano Anabel , Valor Carmen , Chuvieco Emilio
Published: September 2020

Background: Due to the current environmental crisis, sustainable consumption (SC) behaviour and its drivers has gained significant attention among researchers. One of the potential drivers of SC, religion, have been analysed in the last few years. The study of the relationship between religion and adoption of SC at the individual level have reached mixed and inconclusive results. Methods: Following the PRISMA guidelines, a systematic review of articles published between 1998 and 2019 was conducted using the Web of Science and Scopus databases. Search terms included sustainable consumption, green consumption, ethical consumption, responsible consumption, pro-environmental behaviour and religion. Results: This systematic review reveals that contradictory results are due to methodological and theoretical reasons and provides a unifying understanding about the influence of religion on SC practices. Results highlight the role of religion as a distal or background factor of other proximal determinants of environmental behaviour. Conclusions: This paper contributes to the literature concerning SC by synthesising previous scholarship showing that religion shapes SC indirectly by affecting attitudes, values, self-efficacy, social norms and identity. The review concludes with a research agenda to encourage scholars the study of other unexamined mediating constructs, such as beliefs in after life, cleansing rituals and prayer, moral emotions, moral identity, the role of virtues and self-restrain.
Socio-Environmental Vulnerability Assessment for Sustainable Management
Authors: Szewrański Szymon , Kazak Jan K.
Published: September 2020

Research on complex socio-environmental systems (also known as socio-ecological systems) has a long tradition in scientific considerations [...]
Addressing the Social Aspects of a Circular Economy: A Systematic Literature Review
Authors: Padilla-Rivera Alejandro , Russo-Garrido Sara , Merveille Nicolas
Published: September 2020

Circular Economy (CE) is a growing topic among scholars, industries, and governments, and is aimed at decoupling economic growth and development from the consumption of finite resources. CE incorporates different meanings, from reduce, reuse, and recycle activities, to environmental degradation or resource scarcity, and is supported by specific indicators to attain sustainable development. However, so far, there has been no agreement to measure how effective an industry/product is in making the transition from linear to circular approaches, particularly those that affect society. This research work aims to perform a systematic literature review (n = 60) to analyze and discuss how social aspects have been considered and integrated in CE research so far. Moreover, this review provides an overview of the literature on social impact within the CE, which results in three main outputs: a knowledge map of the CE, an analysis of social aspects within CE, and the theories/frameworks used to evaluate social impact of CE. Finally, this study brings to light how CE implementation can affect society and highlights the importance of social dimension in the domains of CE and a policy-making community, which could help move CE towards a sustainable development.
Analyzing the Relationships between Citizens’ Emotions and their Momentary Satisfaction in Urban Public Spaces
Authors: Weijs-Perrée Minou , Dane Gamze , van den Berg Pauline
Published: September 2020

It is recognized that the urban environment, and specifically better-experienced urban public space, contribute to people’s subjective well-being. However, research on people’s momentary subjective well-being (i.e., emotional state) in relation to the multiple aspects of urban public spaces is still limited. Therefore, the aim of this study was to analyze people’s emotional state and how this is influenced by the momentary satisfaction with urban public spaces, and also controlling for personal and experience characteristics. Data of 1056 momentary experiences of 161 citizens regarding the urban public space in Eindhoven, The Netherlands, were collected by means of an experience sampling method (ESM). These data were analyzed using a mixed multinomial logit (MMNL) model for each dimension of people’s momentary subjective well-being (i.e., sense of security, comfort, happiness, and annoyance). Results of this study showed that people were happier when they were satisfied with the atmosphere of the public space and felt more secure, comfortable, and less annoyed when they were more satisfied with traffic safety. Results could be used by policymakers and urban planners to create inclusive urban public spaces where people have more positive experiences, which eventually could lead to happier, comfortable, more secure and less annoyed citizens.
Simulation Methodology-Based Context-Aware Architecture Design for Behavior Monitoring of Systems
Authors: Cho Tae Ho
Published: September 2020

Generally, simulation models are constructed to replicate and predict the behavior of real systems that currently exist or are expected to exist in the future. Once a simulation model is implemented, the model can be connected to a real system for which the model has been built through sensors or networks so that important activities in the real system can be monitored indirectly through the model. This article proposes a modeling formalism BM-DEVS (Behavior Monitor-DEVS) that defines simulation models capable of monitoring the desired behavior patterns within the models so that the target system’s behavior can be monitored indirectly. In BM-DEVS, an extension of classic Discrete Event System Specification (DEVS), the behavior to be monitored is expressed as a set of temporal logic (TL) production rules within a multi-component model that consists of multiple component models to be monitored. An inference engine module for reasoning with the TL rules is designed based on the abstract simulator that carries out instructions in the BM-DEVS models to perform the simulation process. The major application of BM-DEVS is in the design and implementation of the context-aware architecture needed for various intelligent systems as a core constituent. Essentially all systems where some form of behavior monitoring is required are candidate applications of BM-DEVS. This research is motivated by the view that there exists symmetry between the real-world and the cyber world, in that the problems in both environments should be expressed with the same basic constituents of time and space; this naturally leads to adopting spatiotemporal variables composed of simulation models and developing a problem solver that exploits these variables.
Nematic and Smectic Phases: Dynamics and Phase Transition
Authors: Bailly-Reyre Aurélien , Diep Hung T.
Published: September 2020

We study in this paper the dynamics of molecules leading to the formation of nematic and smectic phases using a mobile 6-state Potts spin model with Monte Carlo simulation. Each Potts state represents a molecular orientation. We show that, with the choice of an appropriate microscopic Hamiltonian describing the interaction between individual molecules modeled by 6-state Potts spins, we obtain the structure of the smectic phase by cooling the molecules from the isotropic phase to low temperatures: molecules are ordered in independent equidistant layers. The isotropic-smectic phase transition is found to have a first-order character. The nematic phase is also obtained with the choice of another microscopic Hamiltonian. The isotropic-nematic phase transition is a second-order one. The real-time dynamics of the molecules leading to the liquid-crystal ordering in each case is shown by a video.
Critical Success Factors of the Reliability-Centred Maintenance Implementation in the Oil and Gas Industry
Authors: Zeinalnezhad Masoomeh , Chofreh Abdoulmohammad Gholamzadeh , Goni Feybi Ariani , Klemeš Jiří Jaromír
Published: September 2020

Reliability-Centred Maintenance (RCM) is a strategic process to improve the maintenance planning of companies which contributes to sustainable production. This method has been applied by numerous industries to achieve an efficient maintenance process, but many have not fully completed their goals. The reason for this failure is that RCM implementation is complex, and organisations need to have adequate preparations before they implement it. In the pre-implementation phase, it is necessary to know the number of Critical Success Factors (CSFs) as a critical measure for implementing the RCM method successfully. Therefore, it is important for practitioners to apply a symmetric mechanism involving fuzzy systems to achieve the desired RCM implementation. There are a limited number of studies that have observed these factors regarding the characteristics of oil and gas companies, especially in the pre-implementation phase. Addressing RCM pre-implementation issues is of high importance from the economic perspective of sustainability for oil and gas organisations. The objective of this study is to investigate significant items in RCM pre-implementation through a combination of quantitative and qualitative analyses. The Nominal Group Technique (NGT) method is applied by gaining the opinion of experts to determine the factors and prioritising them using mathematical modelling. A group of related experts from the oil and gas industry were initially interviewed and surveyed to determine the critical success factors. These identified factors were then analysed using quantitative analysis to identify the important degrees and scored using Fuzzy Analytic Network Process (FANP). Fifteen major factors affecting the criticality of successful RCM implementation have been identified and prioritised, based on their weights. The model proposed in this study could be used as a guideline for assessing CSFs in other countries. To apply the proposed model in different contexts, it needs to be modified according to the needs, policies, and perspectives of each country.
In Vitro and In Vivo Evaluation of the Toxic Effects of Dodecylguanidine Hydrochloride
Authors: Lim Yeon-Mi , Kim Haewon , Lim Seong Kwang , Yoo Jean , Lee Ji-Young , Eom Ig-Chun , Yoon Byung-Il , Kim Pilje , Yu Seung-Do , Shim Ilseob
Published: September 2020

The toxicity profiles of the widely used guanidine-based chemicals have not been fully elucidated. Herein, we evaluated the in vitro and in vivo toxicity of eight guanidine-based chemicals, focusing on inhalation toxicity. Among the eight chemicals, dodecylguanidine hydrochloride (DGH) was found to be the most cytotoxic (IC50: 0.39 μg/mL), as determined by the water soluble tetrazolium salts (WST) assay. An acute inhalation study for DGH was conducted using Sprague-Dawley rats at 8.6 ± 0.41, 21.3 ± 0.83, 68.0 ± 3.46 mg/m3 for low, middle, and high exposure groups, respectively. The levels of lactate dehydrogenase, polymorphonuclear leukocytes, and cytokines (MIP-2, TGF-β1, IL-1β, TNF-α, and IL-6) in the bronchoalveolar lavage fluid increased in a concentration-dependent manner. Histopathological examination revealed acute inflammation with necrosis in the nasal cavity and inflammation around terminal bronchioles and alveolar ducts in the lungs after DGH inhalation. The LC50 of DGH in rats after exposure for 4 h was estimated to be >68 mg/m3. Results from the inhalation studies showed that DGH was more toxic in male rats than in female rats. Overall, DGH was found to be the most cytotoxic chemical among guanidine-based chemicals. Exposure to aerosols of DGH could induce harmful pulmonary effects on human health.
Spatial Distribution and Ecological Risks of the Potentially-Toxic Elements in the Surface Sediments of Lake Bosten, China
Authors: Ma Long , Abuduwaili Jilili , Liu Wen
Published: September 2020

Aiming at the pollution and ecological hazards of the lake sediments of Bosten Lake, once China’s largest inland lake, the spatial distribution and influencing factors of the potentially-toxic elements in its surface sediments were studied with the methods of spatial autocorrelation, two-way cluster analysis, and redundancy analysis. Finally, based on the background value of potentially-toxic elements extracted from a sediment core, a comprehensive evaluation of the risk of these potentially-toxic elements was conducted with the potential-ecological-risk index and the pollution-load index. With data on the grain size, bulk-rock composition, and organic matter content, this comprehensive analysis suggested that with the enrichment of authigenic carbonate minerals, the content of potentially-toxic elements exhibited distinctive characteristics representative of arid regions with lower values than those in humid region. All potentially-toxic elements revealed a significant spatial autocorrelation, and high-value areas mainly occurred in the middle and southwest. The content of potentially-toxic elements is related to Al2O3, K2O, Fe2O3, TiO2, MgO, and MnO, and the storage medium of potentially-toxic elements mainly consists of small particles with a grain size <16 μm. The pollution load index (PLI) for the whole lake due to the potentially-toxic elements was 1.31, and the surface area with a PLI higher than 1 and a moderate pollution level accounted for 87.2% of the total lake area. The research conclusions have an important scientific value for future lake ecological quality assessment and lake environment governance.
Dengue and Zika Viruses: Epidemiological History, Potential Therapies, and Promising Vaccines
Authors: Silva Nelly M. , Santos Nuno C. , Martins Ivo C.
Published: September 2020

Dengue virus (DENV), which can lead to fatal hemorrhagic fever, affects 390 million people worldwide. The closely related Zika virus (ZIKV) causes microcephaly in newborns and Guillain-Barré syndrome in adults. Both viruses are mostly transmitted by Aedes albopictus and Aedes aegypti mosquitoes, which, due to globalization of trade and travel alongside climate change, are spreading worldwide, paving the way to DENV and ZIKV transmission and the occurrence of new epidemics. Local outbreaks have already occurred in temperate climates, even in Europe. As there are no specific treatments, these viruses are an international public health concern. Here, we analyze and discuss DENV and ZIKV outbreaks history, clinical and pathogenesis features, and modes of transmission, supplementing with information on advances on potential therapies and restraining measures. Taking advantage of the knowledge of the structure and biological function of the capsid (C) protein, a relatively conserved protein among flaviviruses, within a genus that includes DENV and ZIKV, we designed and patented a new drug lead, pep14-23 (WO2008/028939A1). It was demonstrated that it inhibits the interaction of DENV C protein with the host lipid system, a process essential for viral replication. Such an approach can be used to develop new therapies for related viruses, such as ZIKV.
Identification of Modulators of HIV-1 Proviral Transcription from a Library of FDA-Approved Pharmaceuticals
Authors: Sampey Gavin C. , Iordanskiy Sergey , Pleet Michelle L. , DeMarino Catherine , Romerio Fabio , Mahieux Renaud , Kashanchi Fatah
Published: September 2020

Human immunodeficiency virus 1 (HIV-1) is the most prevalent human retrovirus. Recent data show that 34 million people are living with HIV-1 worldwide. HIV-1 infections can lead to AIDS which still causes nearly 20,000 deaths annually in the USA alone. As this retrovirus leads to high morbidity and mortality conditions, more effective therapeutic regimens must be developed to treat these viral infections. A key target for intervention for which there are no current FDA-approved modulators is at the point of proviral transcription. One successful method for identifying novel therapeutics for treating infectious diseases is the repurposing of pharmaceuticals that are approved by the FDA for alternate indications. Major benefits of using FDA-approved drugs include the fact that the compounds have well established toxicity profiles, approved manufacturing processes, and immediate commercial availability to the patients. Here, we demonstrate that pharmaceuticals previously approved for other indications can be utilized to either activate or inhibit HIV-1 proviral transcription. Specifically, we found febuxostat, eltrombopag, and resveratrol to be activators of HIV-1 transcription, while mycophenolate was our lead inhibitor of HIV-1 transcription. Additionally, we observed that the infected cells of lymphoid and myeloid lineage responded differently to our lead transcriptional modulators. Finally, we demonstrated that the use of a multi-dose regimen allowed for enhanced activation with our transcriptional activators.
Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination
Authors: Crofts Kali F. , Alexander-Miller Martha A.
Published: September 2020

The initial months of life reflect an extremely challenging time for newborns as a naïve immune system is bombarded with a large array of pathogens, commensals, and other foreign entities. In many instances, the immune response of young infants is dampened or altered, resulting in increased susceptibility and disease following infection. This is the result of both qualitative and quantitative changes in the response of multiple cell types across the immune system. Here we provide a review of the challenges associated with the newborn response to respiratory viral pathogens as well as the hurdles and advances for vaccine-mediated protection.
Possible Cross-Reactivity between SARS-CoV-2 Proteins, CRM197 and Proteins in Pneumococcal Vaccines May Protect Against Symptomatic SARS-CoV-2 Disease and Death
Authors: Root-Bernstein Robert
Published: September 2020

Various studies indicate that vaccination, especially with pneumococcal vaccines, protects against symptomatic cases of SARS-CoV-2 infection and death. This paper explores the possibility that pneumococcal vaccines in particular, but perhaps other vaccines as well, contain antigens that might be cross-reactive with SARS-CoV-2 antigens. Comparison of the glycosylation structures of SARS-CoV-2 with the polysaccharide structures of pneumococcal vaccines yielded no obvious similarities. However, while pneumococcal vaccines are primarily composed of capsular polysaccharides, some are conjugated to cross-reacting material CRM197, a modified diphtheria toxin, and all contain about three percent protein contaminants, including the pneumococcal surface proteins PsaA, PspA and probably PspC. All of these proteins have very high degrees of similarity, using very stringent criteria, with several SARS-CoV-2 proteins including the spike protein, membrane protein and replicase 1a. CRM197 is also present in Haemophilus influenzae type b (Hib) and meningitis vaccines. Equivalent similarities were found at lower rates, or were completely absent, among the proteins in diphtheria, tetanus, pertussis, measles, mumps, rubella, and poliovirus vaccines. Notably, PspA and PspC are highly antigenic and new pneumococcal vaccines based on them are currently in human clinical trials so that their effectiveness against SARS-CoV-2 disease is easily testable.
Modelling Pluvial Flooding in Urban Areas Coupling the Models Iber and SWMM
Authors: Sañudo Esteban , Cea Luis , Puertas Jerónimo
Published: September 2020

Dual urban drainage models allow users to simulate pluvial urban flooding by analysing the interaction between the sewer network (minor drainage system) and the overland flow (major drainage system). This work presents a free distribution dual drainage model linking the models Iber and Storm Water Management Model (SWMM), which are a 2D overland flow model and a 1D sewer network model, respectively. The linking methodology consists in a step by step calling process from Iber to a Dynamic-link Library (DLL) that contains the functions in which the SWMM code is split. The work involves the validation of the model in a simplified urban street, in a full-scale urban drainage physical model and in a real urban settlement. The three study cases have been carefully chosen to show and validate the main capabilities of the model. Therefore, the model is developed as a tool that considers the main hydrological and hydraulic processes during a rainfall event in an urban basin, allowing the user to plan, evaluate and design new or existing urban drainage systems in a realistic way.
Performance of Three Sorghum Cultivars under Excessive Rainfall and Waterlogged Conditions in the Sudano-Sahelian Zone of West Africa: A Case Study at the Climate-Smart Village of Cinzana in Mali
Authors: Müller Manuel , Dembélé Siaka , Zougmoré Robert , Gaiser Thomas , Partey Samuel
Published: September 2020

Recent climate analyses show trends for increasing precipitation variability with increasing precipitation sums in Mali. The increasing occurrence of temporary intra-seasonal droughts and waterlogging longer than a week demands climate-smart solutions. Research has focused on water deficits since the 1980s. However, besides droughts, waterlogging can restrict productivity of sensitive cash and staple crops as cotton and corn. The year 2019 offered the historically unique opportunity to monitor waterlogging effects with 1088 mm precipitation in the rural commune Cinzanawith an isohyet of 681 mm. Impacts of two extreme downpours on three sorghum cultivars were monitored in a farmers-field experiment with three replications. All sorghum cultivars performed well in 2019 with significantly higher grain and above ground biomass yields than in the reference year 2007, with well distributed rainfall in Cinzana. “Jakumbè” (CSM63E) produced significantly higher grain yields than the hybrid cultivar “PR3009B” bred for high harvest index. The local cultivar “Gnofing” selected by local farmers produced significantly higher above ground biomass. All cultivars tolerated without severe stress symptoms 20 days waterlogging and 72 h inundation. Further waterlogging resilience research of other crops and other sorghum cultivars is needed to strengthen food security in Mali with expected increasing precipitation variation in the future.
Behavior of UV Filters, UV Blockers and Pharmaceuticals in High Rate Algal Ponds Treating Urban Wastewater
Authors: Vassalle Lucas , Sunyer-Caldú Adrià , Díaz-Cruz M. Silvia , Arashiro Larissa Terumi , Ferrer Ivet , Garfí Marianna , García-Galán Mª Jesús
Published: September 2020

The present study evaluated the efficiency of a high rate algal pond (HRAP) at pilot scale to remove pharmaceuticals and personal care products (PPCPs) from urban wastewater, including UV-filters and parabens (10), benzotriazoles (4), antibiotics (15), anti-inflammatories (3) and other pharmaceuticals (3). A total of 35 compounds were targeted, of which 21 were detected in the influent wastewater to the HRAP. Removals (RE%) for pharmaceuticals were variable, with efficient eliminations for atenolol (84%) and sulfathiazole (100%), whereas the anti-inflammatories naproxen and ketoprofen were only partially removed <50%. Benzotriazoles showed elimination rates similar to those of conventional WWTPs, with RE% ranging from no elimination to 51% for the UV filter benzophenone-3 (BP3) and 100% for 4-methylbenzilidenecamphor (4MBC). Hazard quotients (HQs) were estimated for those compounds not fully eliminated in the HRAP, as well as the cumulative ecotoxicity in the resulting effluent. The majority of the compounds yielded HQs < 0.1, meaning that no environmental risk would be derived from their discharge. Overall, these results clearly indicate that HRAPs are a reliable, green and cost-effective alternative to intensive wastewater treatment, yielding promising results removing these contaminants.
Quantifying Contributions of Climate Change and Local Human Activities to Runoff Decline in the Second Songhua River Basin
Authors: Shanshan Bao , Wei Yang , Xiaojun Wang , Hongyan Li
Published: September 2020

In the past several decades, climate change and human activities have influenced hydrological processes, and potentially caused more frequent and extensive flood and drought risks. Therefore, identification and quantification of the driving factors of runoff variation have become a hot research area. This paper used the trend analysis method to show that runoff had a significant downward trend during the past 60 years in the Second Songhua River Basin (SSRB) of Northeast China. The upper, middle, and lower streams of five hydrological stations were selected to analyze the breakpoint of the annual runoff in the past 60 years, and the breakpoints were used to divide the entire study period into two sub-periods (1956–1974 and 1975–2015). Using the water–energy coupling balance method based on Choudhury–Yang equation, the climatic and catchment landscape elasticity coefficient of the annual runoff change was estimated, and attribution analysis of the runoff change was carried out for the Fengman Reservoir and Fuyu stations in SSRB. The change in potential evapotranspiration has a weak effect on the runoff, and change in precipitation and catchment landscape were the leading factors affecting runoff. Impacts of climate change and land cover change were accountable for the runoff decrease by 80% and 11% (Fengman), 17% and 206% (Fuyu) on average, respectively; runoff was more sensitive to climate change in Fengman, and was more sensitive to catchment landscape change in Fuyu. In Fengman, the population was small, owing to the comparatively inhospitable natural conditions, and so human activities were low. However, in Fuyu, human activities were more intensive, and so had more impact on runoff for the Lower Second Songhua River compared to the Upper Second Songhua River.