bluuebunny/crossref_metadata_2025 huggingface dataset:
FOXO3a Induces Myocardial Fibrosis by Upregulating Mitophagy
Authors: Lin Dongsheng , Luo Hui , Dong Bo , He Zhongchun , Ma Lixia , Wang Zhaofei , Wu Xianliang , Sui Qian
Published: February 2024

Background: Atrial fibrillation is one of the most common cardiac arrhythmias. Myocardial fibrosis is closely associated with atrial remodeling, which leads to heightened risk of atrial fibrillation. This study aimed to explore whether forkhead box protein O3 (FOXO3a) impacts myocardial fibrosis incidence by regulating mitophagy. Methods: Cell viability was assessed by cell counting kit-8 (CCK-8) assays. The expression of vimentin and cytochrome C was detected by immunofluorescence assays. Quantitative real-time polymerase chain reaction (PCR) was used to analyze the relative mRNA level of FOXO3a. Expression of FOXO3a, phosphorylated FOXO3a, Collagen I, Collagen III, alpha-smooth muscle actin (α-SMA), matrix metalloprotease 9 (MMP9), light chain 3 (LC3), phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1), Parkin, and sequestosome-1 (p62) proteins were determined by western blotting. 5-ethynyl-2′-deoxyuridine (EDU) incorporation was employed to measure cell proliferation. Changes in mitochondrial membrane potential were determined by 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide (JC-1) staining. A wound healing assay was used to examine cell migration, and the levels of reactive oxygen species were determined by flow cytometry. Results: The expression of FOXO3a was upregulated in cardiac fibroblasts treated with angiotensin II (AngII), while the expression of phosphorylated FOXO3a was downregulated under these conditions. FOXO3a knockdown significantly inhibited the proliferation, migration and collagen secretion of cardiac fibroblasts treated with AngII. The ratio of LC3 II/I as well as expression of PINK1 and Parkin was increased, and the expression of p62 was decreased, in cardiac fibroblasts treated with AngII. Moreover, these effects were limited by FOXO3a knockdown. Finally, the mitophagy inducer everolimus (RAD001) attenuated the suppressive effect of FOXO3a knockdown on cardiac fibroblast activation. Conclusions: FOXO3a promotes the progress of myocardial fibrosis by triggering mitophagy in cardiac fibroblasts.
Genome-Wide Identification, Sequence Alignment, and Transcription of Five Sex-Related Genes in Largemouth Bass (Micropterus Salmoides)
Authors: Zhang Xinhui , Ruan Zhiqiang , Sun Chengfei , Hu Cancan , Huang Yu , You Xinxin , Wang Xinwen , Xu Junmin , Liu Huan , Liu Xin , Ye Xing , Shi Qiong
Published: February 2024

Background: Largemouth bass (Micropterus Salmoides) is an economically important fish species in China. Most research has focused on its growth, disease resistance, and nutrition improvement. However, the sex-determining genes in largemouth bass are still unclear. The transforming growth factor-beta (TGF-β) gene family, including amh, amhr2 and gsdf, plays an important role in the sex determination and differentiation of various fishes. These genes are potentially involved in sex determination in largemouth bass. Methods: We performed a systematic analysis of 5 sex-related genes (amh, amhr2, gsdf, cyp19a1, foxl2) in largemouth bass using sequence alignment, collinearity analysis, transcriptome, and quantitative real-time polymerase chain reaction (qRT-PCR). This included a detailed assessment of their sequences, gene structures, evolutionary traits, and gene transcription patterns in various tissues including gonads, and at different developmental stages. Results: Comparative genomics revealed that the 5 sex-related genes were highly conserved in various fish genomes. These genes did not replicate, mutate or lose in largemouth bass. However, some were duplicated (amh, amhr2 and gsdf), mutated (gsdf) or lost (amhr2) in other fishes. Some genes (e.g., gsdf) showed significant differences in genomic sequence between males and females, which may contribute to sex determination and sex differentiation in these fishes. qRT-PCR was applied to quantify transcription profiling of the 5 genes during gonadal development and in the adult largemouth bass. Interestingly, amh, amhr2 and gsdf were predominantly expressed in the testis, while cyp19a1 and foxl2 were mainly transcribed in the ovary. All 5 sex-related genes were differentially expressed in the testes and ovaries from the 56th day post-fertilization (dpf). We therefore speculate that male/female differentiation in the largemouth bass may begin at this critical time-point. Examination of the transcriptome data also allowed us to screen out several more sex-related candidate genes. Conclusions: Our results provide a valuable genetic resource for investigating the physiological functions of these 5 sex-related genes in sex determination and gonadal differentiation, as well as in the control of gonad stability in adult largemouth bass.
Immune Response Associated Gene Signatures in Aortic Dissection Compared to Aortic Aneurysm
Authors: Doppler Christian , Rezk Marlene , Arbeithuber Barbara , Bernhard David
Published: February 2024

Background: Thoracic aortic dissections (TAD) are life-threatening events mostly requiring immediate surgical treatment. Although dissections mainly occur independently of thoracic aortic aneurysms (TAA), both share a high comorbidity. There are several indications for an involvement of the immune system in the development of TAD, just as in TAA. Nevertheless, specific disease-relevant genes, biomolecular processes, and immune-specific phenotypes remain unknown. Methods: RNA from isolated aortic smooth muscle cells from TAD (n = 4), TAA (n = 3), and control patients were analyzed using microarray-based technologies. Additionally, three publicly available bulk RNA-seq studies of TAD (n = 23) and controls (n = 17) and one single-cell RNA-seq study of TAA (n = 8) and controls (n = 3) were analyzed. Differentially expressed genes were identified and used to identify affected pathways in TAD. Five selected genes were validated by quantitative real-time polymerase chain reaction (PCR). Results: We identified 37 genes that were significantly dysregulated in at least three TAD studies—24 of them were not shown to be associated with TAD, yet. Gene ontology analysis showed that immune response was significantly affected. Five of the genes (CCL2, RNASE2, HAVCR2, CXCL8, and IL6R) were revealed as core genes that affect immune response in TAD. We compared the gene expression of those genes to TAA and found that CXCL8, IL6R, and potentially also CCL2 were upregulated in TAD. Conclusions: The identified immune-related genes showed TAD-specificity, independent of possible pre-existing comorbidities like TAA. So, these genes represent potential biomarkers and therapeutic targets linked to the immune response in acute TAD. Additionally, we identified a set of differentially expressed genes that represents a resource for further studies.
Αργή και γρήγορη σκέψη και εκπαίδευση στις φυσικές επιστήμες
Authors: Gousopoulos Dimitrios
Published: February 2024

In recent years there has been growing evidence that even after teaching designed to address the learning difficulties dictated by literature, many physics learners fail to create the proper reasoning chains that connect the fundamental principles and lead to reasoned predictions. Even though students have the required knowledge and skills, they are often based on a variety of intuitive reasoning that leads them to wrong conclusions. This paper studies students' reasoning on science problems through heuristic-analytical thought processes (System 1 - System 2). System 1 operates automatically and quickly with little or no effort and no sense of voluntary control, while System 2 focuses on the demanding mental activities that require it and is slow based on rules.
Infant Neural Speech Encoding Forecasts Language Difficulties in Preschool Years
Authors: Wong Patrick , Pan Shaoqi , Lai Eva , Chan Peggy , Feng Gangyi , Lam Hugh Simon , Leung Tak Yeung , Novitskiy Nikolay , Leung Ting Fan
Published: February 2024

AbstractImportance: Developmental language problems must be detected early to capitalize on the high effectiveness of early intervention. Because developmental language problems are not formally diagnosed until preschool years, a method must be developed and validated to forecast language problems from as early as infancy. Objective: To develop and validate predictive models of language problems using neural data collected from as early as infancy and language problems detected at up to 36 months of age.Design: A cohort study with initial electroencephalography (EEG) neural encoding of speech data collected between 3 weeks and 24 months of age and language outcome data collected between 7 and 36 months of age. The data reported were collected between 2016 and 2024. The cutoff date for analysis was March 25, 2024.Setting: Laboratory and home. Participants: A total of 726 healthy children from a community sample were recruited, 534 of whom with complete EEG and follow-up language data were included in the final analysis.Exposure: Early- and long-latency EEG responses to three speech stimuli (two native and one non-native) were collected. No intervention was involved.Main Outcome Measures: The Chinese Communicative Development Inventory – Cantonese version (CCDI-C) and the language subscale of the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III).Results: Random Forest was used as the machine learning algorithm to classify children into binary groups of below or at or above 16th percentile on the outcome measures. Different predictive models were constructed and compared, including those with and without EEG and clinical measures. Models with non-neural measures (e.g., gestational age and birth weight) predicted a language outcome above chance level. Models with EEG measures alone outperformed any models without neural features, with sensitivity and Area Under Curve (AUC) scoring well above 90% for the best models. When validated using unseen data, both sensitivity and AUC remained at 88%.Conclusion & Relevance: EEG neural encoding of speech can be a new procedure for screening language developmental problems as early as infancy. Families with children who are screened positive may consider early intervention in the form of parent coaching to promote better language development.
Cross-cultural studies on concepts of lying: methodological approaches and their findings. Forthcoming in: A. Wiegmann (ed): Lying, Fake News, and Bullshit. Bloomsbury: Advances in Experimental Philosophy.
Authors: Erut Alejandro
Published: February 2024

Concepts help us to represent the world. They underly how we organize our thinking regarding beliefs and complex structures, such as prototypes or theories. While some concepts appear universally present–likely due to evolved mechanisms– others seem to be culturally specific or embedded in complex cultural phenomena. Based on the existing literature, I will address where the concept of lying lies in the continuum between universalism and particularism, what we know about cultural differences in the concept of lying, and how the concept has been studied cross-culturally so far. Additionally, I will discuss the difficulties that the phenomenon of lying poses when aiming to understand it from a comparative perspective.
How Does the “Default Mode” Network Contribute to Semantic Cognition?
Authors: Fernandino Leonardo , Binder Jeffrey R
Published: February 2024

This review examines whether and how the “default mode” network (DMN) contributes to semantic processing. We review evidence implicating the DMN in the processing of individual word meanings and in sentence- and discourse-level semantics. Next, we argue that the areas that make up the DMN contribute to semantic processing by coordinating and integrating the simultaneous activity of local neuronal ensembles across multiple multimodal and unimodal cortical regions, creating a transient, global neuronal ensemble. The resulting ensemble implements an integrated simulation of phenomenological experience—that is, an embodied situation model—constructed from various modalities of experiential memory traces. We argue that these situation models are necessary not only for semantic processing but also for aspects of cognition that are not traditionally considered semantic. Although many aspects of this proposal remain provisional, we believe that it provides new insights into the relationships between semantic and nonsemantic cognition and into the functions of the DMN.
Roteiro para redação de estudos em farmacoepidemiologia conduzidos a partir de dados de saúde observacionais coletados rotineiramente (RECORD-PE), tradução para o Português
Authors: Langan Sinead , Schmidt Sigrún AJ , Wing Kevin , Ehrenstein Vera , Nicholls Stuart , Filion Kristian , Klungel Olaf , Petersen Irene , Sørensen Henrik Toft , Dixon William G , Guttmann Astrid , Harron Katie , Hemkens Lars G. , Moher David , Schneeweiss Sebastian , Smeeth Liam , Sturkenboom Miriam , von Elm Erik , Wang Shirley , Benchimol Eric I
Published: February 2024

Este artigo foi originalmente publicado em inglês (Langan SM, Schmidt SA, Wing K, et al. The reporting of studies conducted using observational routine collected health data statement for pharmacoepidemiology (RECORD-PE). BMJ 2018;363:k3532). Foi traduzido para o português por Tatiane Bomfim Ribeiro (Programa de Pós graduação em Epidemiologia, Faculdade de Saúde Pública - Universidade de São Paulo, São Paulo, Brasil), Lisiane Freitas Leal (Department of Epidemiology, Biostatistics and Occupational Health - McGill University, Montreal, Canadá), Luciane Cruz Lopes (Universidade de Sorocaba, São Paulo, Brasil), e depois traduzido novamente para o inglês por Michael Maia Schlussel (The EQUATOR Network, Centre for Statistics in Medicine, NDORMS - University of Oxford, Oxford, Reino Unido). A contra tradução foi revisada e comparada com a publicação original pelo Comitê Diretivo do RECORD, para maior precisão. Esta tradução foi endossada pelo Comitê Diretivo do RECORD. Em farmacoepidemiologia, os dados coletados rotineiramente a partir de registros eletrônicos de saúde (incluindo banco de dados da atenção primária, registros e bases administrativas para reembolso em saúde) são um recurso para pesquisas com intuito de avaliar a efetividade e a segurança dos medicamentos no mundo real. As diretrizes atualmente disponíveis para a redação de pesquisa utilizando dados não randomizados coletados rotineiramente - especificamente o REporting of studies Conducted using Observational Routinely collected health Data (RECORD) e Strengthening the Reporting of OBservational studies in Epidemiology (STROBE) - não capturam a complexidade da pesquisa farmacoepidemiológica. Assim, os autores ampliaram o roteiro RECORD para incluir diretrizes específicas para pesquisa farmacoepidemiológica (RECORD-PE). Este artigo inclui a lista de verificação do RECORD-PE (também disponível em www.record-statement.org) e explica cada item da lista de verificação com exemplos para o reporte adequado. Os autores anteviram que o uso crescente das diretrizes do RECORD-PE por pesquisadores, e também o endosso e adesão pelos editores das revistas, aprimorarão os padrões para redação de estudos farmacoepidemiológicos, realizados com dados coletados rotineiramente. Esta melhoria na transparência da redação beneficiará a comunidade científica, o cuidado do paciente e a saúde pública.
Co-creating and hosting PxP: A conference about patient engagement in research for and by patient partners
Authors: Richards Dawn P. , Mulhall Hetty , Belton Joletta , de Souza Savia , Flynn Trudy , Haagaard Alex , Hunter Linda , Price Amy , Riggare Sara , Tufte Janice Elizabeth , Twomey Rosemary , Khan Karim
Published: February 2024

Research projects, initiatives and conferences that include patients as partners rather than as participants are becoming more common. Including patients as research partners is an approach called patient engagement or involvement in research, and we will call it patient engagement throughout this paper. Patient engagement moves traditional health research conferences and events to include a broader audience for their knowledge exchange and community building efforts, beyond academics and healthcare professionals. However, there are few examples of conferences where patients are given the opportunity to fully lead. Our conference went beyond patient engagement – it was patient-led. Patient partners conceived, planned, and decided on all aspects of a virtual conference. We present the work and processes we undertook throughout 2023 to create and produce a conference called “PxP: For patients, by patients” or PxP for short, with a tagline of “Partnering to make research stronger.” PxP was patient-led, about patient engagement in research, and supported by the Canadian Institutes of Health Research Institute of Musculoskeletal Health and Arthritis and was not specific to any disease or condition. The PxP website, also known as the PxP Hub, now houses the recordings from the conference along with a variety of resources about patient engagement in research. These resources were recommended by the PxP Steering Committee members, speakers, and other patient partners who attended the 2023 conference. We lead you through how the idea for PxP was generated; how the international patient partner Steering Committee was convened and supported; how PxP was brought to life over a number of months; the PxP 3-day event and feedback collected about it to improve future efforts; trade-offs, challenges and learnings; resources required to support this type of event; and what the future holds for PxP in 2024 and beyond.It’s time to elevate patients into leadership roles for conferences and events, and we encourage you to adopt the PxP ethos by using or adapting our approach and resources to support this model.
Expert-derived recommendations for designing and facilitating tabletop crisis exercises: A Delphi study
Authors: Wallace Keira , Bollfrass Alex , Cooper Owen , Epstein Daniel , Forrest Steven , Lukosch Heide , Mason Roger , Meesters Kenny , Reid Simon , Waring Sara , Widmer Nicolas , Noetel Michael
Published: February 2024

Crises are destabilising, and crisis exercises are one of the core ways that organisations and governments prepare. Not all crisis exercises achieve their goals, and determining how to design them well is difficult to test experimentally. This study aims to identify i) the key goals of discussion-based crisis exercises, ii) what features of design and delivery are important for achieving the aims of discussion-based exercises, and iii) common mistakes. We used a three-round Delphi Method to harness the collective expertise of a diverse range of 16 researchers and professionals. In the first round, experts identified 40 different exercise features. After a further two rounds, consensus was achieved for 29 of the 40 exercise features. Overall, experts agreed on the critical importance of clear objectives, good facilitation, and quality debriefing. Experts also agreed that features such as fidelity and the explicit use of decision-making tools were not essential to achieving the aims of discussion-based exercises. There was disagreement amongst experts with regard to how much say the sponsor should have, how actively involved facilitators should be, and how accountable responders should be held. Overall, these findings are beneficial for exercise designers in highlighting what features to prioritise when designing and delivering discussion-based exercises to best promote organisational learning.
The Processing of Price Comparison is not Holistic but Componential
Authors: Macizo Pedro , Ojedo Fernando
Published: February 2024

In three experiments, we evaluate whether the processing of prices is holistic or componential. When participants receive two prices and they select the higher price, distance effects are found when the distances between the two prices are defined holistically but not when they are defined in terms of digits (Experiment 1). This result suggests that prices are processed holistically. However, we show that the holistic distance effect can be explained by the compatibility between the digits and the monetary category of prices (euro and cent). After controlling for the holistic distance, compatible trials (e.g., 8 euro - 4 cent, 8 > 4 and euro > cent) are processed faster than incompatible trials (e.g., 8 cent - 4 euro, 8 > 4 but cent < euro) with simultaneous and sequential presentation of prices (Experiment 2). Moreover, the compatibility effect is modulated by the ratio of intra monetary category comparisons (8 euro - 6 euro) and inter monetary category comparisons (8 euro - 4 cents) (Experiment 3). The existence of compatibility effects between the digits and the monetary category of prices suggests that cognitive processing of prices is not holistic but componential.
The interplay between effort and reward during experiential and observational category learning
Authors: Roark Casey L , Chandrasekaran Bharath
Published: February 2024

Perceptual categorization requires mapping highly variable sensory signals onto the same category. Some items are clearer examples of the category, being more typical or more distinct from contrasting categories. As a result, individual items differ in the difficulty and effort it takes to categorize them correctly – easier exemplars are more quickly and accurately identified and are therefore less effortful (and difficult exemplars are more effortful). Here, we ask how learners balance effort with reward when learning new categories. We examine rule-based auditory category learning with stimuli varying in the effort required for correct categorization. Three conditions varied in how effort was aligned with reward – high reward for high effort, high reward for low effort, and random reward. We compared results when participants learned from experience, actively exerting effort themselves to learn the categories (Experiment 1) and when participants learned from observing the effortful actions and outcomes of another learner (Experiment 2). Surprisingly, we found that aligning effort and reward was not beneficial for learning and that participants learned the categories and generalized to novel instances regardless of whether they learned through experience or observation. Further, participants only learned the incidental relationship between effort and reward when they learned through experience. When learning through observation, participants defaulted to an expectation that high effort should yield high reward, regardless of the relationship they actually experienced. Overall, generalization of category knowledge is possible through either experiential or observational learning but adjusting expectations about the relationship between effort and reward requires learning from experience.
The influence of spatial and temporal attention on visual awareness - a behavioral and ERP study
Authors: Ciupińska Kinga , Orłowska Wiktoria , Zębrowski Aleksander , Łępa Laura , Koculak Marcin , Bola Michał , Wierzchoń Michał
Published: February 2024

Whether attention is a prerequisite of perceptual awareness or an independent and dissociable process remains a matter of debate. Importantly, understanding the relation between attention and awareness is probably not possible without taking into account the fact that both are heterogeneous and multifaceted mechanisms. Therefore, the present study tested the impact on visual awareness of two attentional mechanisms proposed by the Posner model: temporal alerting and spatio-temporal orienting. Specifically, we evaluated the effects of attention on the perceptual level, by measuring objective and subjective awareness of a threshold-level stimulus; and on the neural level, by investigating how attention affects two postulated ERP correlates of awareness. We found that alerting and orienting mechanisms additively facilitate perceptual consciousness, with activation of the latter resulting in the most vivid awareness. Furthermore, we found that late positivity (LP) is unlikely to constitute a neural correlate of consciousness as its amplitude was modulated by both attentional mechanisms, but early visual awareness negativity (VAN) was independent of the alerting and orienting mechanisms. In conclusion, our study reveals a nuanced relationship between attention and awareness; moreover, by investigating the effect of the alerting mechanism, this study provides insights into the role of temporal attention in perceptual consciousness.
Feature binding is slow: temporal integration explains apparent ultrafast binding
Authors: Blaževski Lucija , Stein Timo , Scholte H. Steven
Published: February 2024

Visual perception involves binding of distinct features into a unified percept. While traditional theories link feature binding to time-consuming recurrent processes, Holcombe and Cavanagh (2001) demonstrated ultrafast, early binding of features that belong to the same object. The task required binding of orientation and luminance within an exceptionally short presentation time. However, because visual stimuli were presented over multiple presentation cycles, their findings can alternatively be explained by temporal integration over the extended stimulus sequence. Here, we conducted three experiments manipulating the number of presentation cycles. If early binding occurs, one extremely short cycle should be sufficient for feature integration. Conversely, late binding theories predict that successful binding requires substantial time and improves with additional presentation cycles. Our findings indicate that task-relevant binding of features from the same object occurs slowly, supporting late binding theories.
Increased Perceived Safety in Day-to-Day Life Relates to Critical National Identification
Authors: Syropoulos Stylianos , Law Kyle Fiore , Leidner Bernhard
Published: February 2024

National identification consistently predicts attitudes within and between groups. Research indicating that threat perceptions often lead to compliance with ingroup authorities suggests that heightened threat perceptions may contribute to stronger submissive national identification. However, the impact of feeling safe on a more critical (in contrast to submissive) sense of national identification remains largely unexplored. Drawing on social safety theory and attachment theory, the present investigation examined whether individual differences in feeling of safety relate to increased critical and submissive/blind forms national identification. Studies 1A-1B and 2A-2B utilized nationally representative data from large cross-national surveys, finding that greater perceived safety related to increased pride in, emotional attachment to and closeness to one’s nation. In Studies 3-5 we find that feeling safe in daily life and believing that one is capable of protecting oneself relate to more ingroup attachment and glorification. Notably, the association for feeling of safety and ingroup attachment was larger than that for ingroup glorification. This investigation offers consistent evidence for a positive association between how safe people feel and national identification, highlighting that more research is needed to better understand how feeling of safety could influence intergroup processes.
The Crucial Role of Research in Postgraduate Periodontics: A Vital Component of Clinical Excellence
Authors: Rijal Arjun Hari
Published: February 2024

Not available.
Effect of Systemically Administered Amoxicillin and Metronidazole in the Treatment of Chronic Periodontitis
Authors: Niraula Sirjana , Shrestha Surendra Man , Pradhan Ameena , Aryal Shreeya , Shrestha Shilu
Published: February 2024

Introduction: Nonsurgical periodontal therapy reduces periodontal inflammation, but complete removal of toxin and bacterial deposits is not always possible. Thus, adjunctive therapeutic strategies like use of systemic amoxicillin and metronidazole have evolved.
Objective: To evaluate effect of systemically administered amoxicillin and metronidazole in the treatment of chronic periodontitis.
Methods: A pretest post-test study was conducted from February 2021 to November 2021 in Department of Periodontics and Oral Implantology at Peoples Dental College and Hospital after ethical clearance from Institutional Review Committee of PDCH.  Thirty-six patients with chronic periodontitis were recruited through convenient sampling. The patients were assigned into two groups meeting the criteria of at least six teeth with probing pocket depth 5-7 mm. Group A received scaling and root planing and Group B received adjunctive systemic Amoxicillin and Metronidazole three times daily for seven days. Clinical parameters were evaluated at one month, three months and six months post-treatment. Data were analysed in SPSS v.20.
Results: Mean values of pocket depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were reduced significantly after treatment in both treatment groups with more clinical improvement in adjunctive systemic amoxicillin and metronidazole. However, on intergroup comparison, clinical attachment level and plaque index was not significantly reduced.
Conclusions: The findings of the current study showed significant improvements in both groups compared with baseline. Thus, adjunctive systemic amoxicillin and metronidazole provide better results than scaling root planing alone.
Hypersensitivity due to Chlorhexidine Digluconate Mouthwash: A Report of an Uncommon Case
Authors: Bhandari Suresh , Shrestha Sajeev , Adhikari Khushbu , Acharya Pujan , Thapa Victory
Published: February 2024

Chlorhexidine is a commonly used mouthwash in dentistry with proven benefits for various periodontal conditions. Various minor side effects may occur after its use in the oral cavity. However, in some uncommon cases, more severe signs and symptoms may develop, which require prompt attention. The present case report describes the clinical findings and management in one such instance where a patient developed a delayed hypersensitivity reaction a few days after the use of Chlorhexidine digluonate mouthwash. The signs and symptoms of the patient gradually subsided after the discontinuation of the mouthwash and the use of an oral antihistaminic medication.
Establishing the Essential Zone: Free Gingival Graft for Gingival Augmentation and Root Coverage
Authors: Sapkota Pratik , Shrestha Sajeev , Adhikari Khushbu , Acharya Pujan , Thapa Victory
Published: February 2024

Gingival recession is a frequently encountered clinical finding which causes compromised aesthetics and dentinal hypersensitivity leading to an inadequate zone of keratinized gingiva and might facilitate subgingival plaque formation resulting in further attachment loss. Epithelized soft tissue graft harvested from the hard palate, commonly known as free gingival graft is simple and highly predictable when used to increase the amount of keratinized tissue. This case report highlights the use of free gingival graft as a gingival augmentation and root coverage procedure for 26-year-old patients with Cairo RT2 mucogingival defects with optimum aesthetic outcome. ­­
हिउँमा लेखिएका नामहरू कवितामा लयविधान {Hiunma Lekhiyeka Namharu Kabitama Layabidhan}
Authors: ढकाल Dhakal विप्लव Biplab
Published: February 2024

‘हिउँमा लेखिएका नामहरू’ मुक्त लयमा आधारित एउटा छोटो गद्यकविता हो। लयविधानका परम्परागत एवं शास्त्रीय नियमहरूको बन्धनमा नबाँधिएको यस कवितामा सहज, स्वतःस्फूर्त र अनियोजित रूपमा मुक्त लयको सघन तीव्रता रहेको छ । यस कवितामा विषम आयामिक पङ्क्तिविन्यास, पदक्रम विचलन र लेख्यचिह्नको प्रयोगबाट लयप्रवाहलाई नियमन गरिएको छ भने समानान्तरता तथा सामान्य भाषिक आवृत्ति लयविधानका मूल कारकका रूपमा रहेका छन्।कवितामा मुक्त लयको उत्पादन, नियमन, व्यवस्थापन र अग्रभूमीकरणका लागि समग्र लयविधायक तत्वहरूको एकीकृत सहकार्यबाट निर्मित लयगत एकत्वको निर्णायक भूमिका रहेको छ ।
Hubungan Self Efficacy dengan Persiapan Kehamilan Sehat Pada Calon Pengantin Wanita
Authors: Nina Nina Sefia Sari , Toyibah Afnani , Apsari Duhita Dyah , Triningsih Reni Wahyu
Published: February 2024

Self efficacy mempengaruhi perilaku kesehatan seseorang termasuk perilaku mempersiapkan kehamilan pada masa prakonsepsi. Kehamilan yang tidak dipersiapkan dengan baik dapat memicu terjadinya berbagai masalah dalam kehamilan dan persalinan seperti; KEK, anemia, pendarahan antepartum, dan BBLR. Tujuan penelitian ini bertujuan untuk menganalisis hubungan self efficacy dengan persiapan kehamilan sehat pada calon pengantin wanita. Desain penelitian yang digunakan adalah analitik korelasi dengan pendekatan cross sectional. Populasi calon pengantin wanita di KUA Lowokwaru yang menikah pada bulan April – Mei 2023. Pengambilan sampel dilakukan menggunakan teknik purposive sampling dengan jumlah 57 responden yang telah memenuhi kriteria inklusi. Instrumen yang digunakan adalah kuesioner Perceived Health Competence Scale (PHCS) dan kuesioner persiapan kehamilan. Hasil analisis uji korelasi spearman rank menunjukkan koefisien korelasi 0,359 dengan taraf signifikasi 0,006 < 0,05 yang menunjukkan ada hubungan sedang antara self efficacy dengan persiapan kehamilan sehat pada calon pengantin wanita di KUA Lowokwaru, Malang. Kesimpulan: Semakin tinggi self efficacy maka persiapan kehamilannya semakin baik. Maka, sebaiknya dilakukan peningkatan pemberian informasi mengenai pentingnya meyakinkan diri untuk mengelola kesehatan dan mempersiapkan kehamilan kepada remaja.
Analisis Sentimen Ulasan Aplikasi Identitas Kependudukan Digital Pada Play Store Menggunakan Metode Naïve Bayes
Authors: Komarudin Ahmad , Hilda Atiqah Meutia
Published: February 2024

Salah satu inovasi baru pemerintah yaitu diadakannya Identitas Kependudukan Digital yang mana hal ini untuk membawa transformasi dalam cara masyarakat membuktikan identitasnya sendiri, membuatnya lebih mudah, aman, dan efisien dalam berbagai konteks kehidupan sehari-hari. Diketahui pada 20 Oktober 2023 aplikasi Identitas Kependudukan Digital hanya memperoleh 3,3 bintang dari 32,7 ribu ulasan. Penelitian ini bertujuan untuk medapatkan sebuah data sentimen dari aplikasi Identitas Kependudukan Digital pada Play Store berupa ulasan-ulasan dari pengguna. Pengambilan data dilakukan menggunakan metode scrapping melalui Google Colab yang hasilnya akan dilabeli negatif dan positif. Kemudian data akan dibersihkan dan disederhanakan melalui preprocessing, dan akan di klasifikasikan dengan algoritma Naïve Bayes.  Hasil klasifikasi selanjutnya dilakukan perhitungan performance dengan confusion matrix dan memperoleh nilai accuracy sebesar 82.23%, precission sebesar 76.08%, dan recall sebesar 94.02%.
Pengembangan Aplikasi Manajemen Litabmas Pendanaan Mandiri dengan Pendekatan Hierarchical Model-View-Controller (HMVC)
Authors: Wahyuni Eka Dyar , Afandi Mohamad Irwan , Putra Agung Brastama
Published: February 2024

Pengelolaan pelaksanaan kegiatan litabmas di suatu perguruan tinggi merupakan suatu kegiatan yang cukup kompleks dan rentan menghadapi permasalahan, apalagi jika dikelola secara tradisional. Arsip sering hilang atau bahkan rusak, kesulitan dalam melacak tanggungan luaran litabmas (artikel, jurnakl, paten/hki dll) periode sebelumnya hingga kesulitan menyediakan informasi dengan cepat. Artikel ini membahas pengembangan aplikasi manajemen litabmas pendanaan mandiri dengan pendekatan Hierarchical Model-View-Controller (HMVC). Pendekatan ini meminimalkan ketergantungan antar modul sehingga memudahkan pengembangan aplikasi secara tim. Aplikasi ini dirancang untuk memberikan solusi dalam mengelola seluruh siklus pelaksanaan kegiatan litabmas, mulai dari perencanaan proposal, evaluasi, hingga pelaporan hasil dan luaran litabmas. Aplikasi diuji dengan metode blackbox, dan menghasilkan 23 usecase yang sudah 100% memberikan output sesuai yang diharapkan.
Pengaruh Pemanasan Terhadap Perubahan Warna Pada Pangan
Authors: Amrih Dewi , Syarifah Atika Nur , Marlinda Gusta , Budiarti Puspita , Safitri Ainun , Nugraha Ihsan Satya Adi , Izzati Nuril Khoirunisa , Lejap Theodorus Yoseph Tatabuang , Maulana Iqbal , Rahmanto Ludi
Published: February 2024

Warna pada makanan dapat disebabkan oleh warna alami baik dari tumbuhan maupun hewan, ataupun warna yang ditambahakan selama proses pengolahan pangan. Selama proses pengolahan pangan, makanan juga dapat terbentuk warna ataupun terjadi perubahan warna. Salah satu pigmen warna alami yang berasal dari tumbuhan adalah antosianin, klorofil dan karotenoid. Penelitian ini bertujuan untuk mengetahui pengaruh pemanasan, baik terbuka maupun tertutup terhadap perubahan warna yang terjadi pada antosianin, klorofil dan karotenoid. Sampel yang digunakan pada penelitian ini adalah ubi ungu (mengandung pigmen antosianin), kacang panjang (mengandung pigmen klorofil), dan wortel (mengandung pigmen karotenoid). Dari hasil pengamatan diperoleh hasil bahwa antosianin dan klorofil memiki sifat peka terhadap panas sehingga mengalami proses degradasi warna pada ubi ungu dan kacang panjang dan juga terlihat warna air rebusan menjadi lebih keruh. Karotenoid memiliki sifat tahan panas sehingga degradasi warna yang terjadi pada sampel wortel hanya sedikit.
Peningkatan Kompetensi UMKM dalam Penyusunan Anggaran Penjualan di Cikarang Pusat
Authors: Asiah Neng , Yahya Adibah , Asti Eka Geovana , Permana Indra , Hidayat Nazwa Putri , Muarif Dede Samsul
Published: February 2024

The goal of sales budget support is to help companies or organisations create, implement, and oversee their own sales budget. The amount left over from the purchase price after products or services are sold for a predetermined period of time is known as the selling price. Analysing past data, answering client questions, determining target markets, and creating winning marketing campaigns are all steps in the process of creating a sales budget. The purpose of this step is to assist employees of SMEs in lowering sales pressure in the context of money management and business growth. This activity is intended to disseminate information about the advantages of lowering the purchase price, how fair competition can assist SMEs in reaching their financial objectives, and how this process can be maximised.  This activity is anticipated to offer insights into the advantages of sales budget support, how SMEs may attain their financial objectives with the appropriate strategy, and how this process can be improved for increased efficacy. By offering advice on how businesses should plan and manage their sales budgets, this activity can also add to the body of knowledge on financial management and business planning. Over time, support from sales budgets can play a significant role in a company's ability to succeed and expand sustainably.
Pengolahan Sampah Polimer Termoplastik dan Termoset di Lingkungan Bank Sampah Induk Kabupaten Jember
Authors: Shofiyah Rohimatush , Irawati Irawati
Published: February 2024

The Jember Regency Main Garbage Bank has the role of fostering and coordinating the Unit Garbage Bank in the Jember Regency area. BSI had several problems in terms of how to sort polymer waste and the need for technological tools for processing plastic polymer waste. The purpose of the PKM activity is to convey knowledge, information and technology for processing plastic polymer waste. The socialization that has been delivered is related to thermoplastic and thermoset polymer waste processing technology based on physical, chemical, technological and mechanical properties, as well as management and marketing strategy for waste bank products. After interviews with BSI and BSU management, discussions with participants, mentoring, and evaluation with partners; The PKM team presented that a Garbage Bank in the city of Jember really needs a plastic polymer waste counting tool to realize the Zero Waste program, increase economic value, usability and aesthetic value. Processing of plastic polymer waste has several methods, namely; recycling plastic waste into handicraft products, turning plastic waste into pellets, processing plastic waste into; fuel oil, brick mixture, and asphalt, recycling process, namely; Hydrogenation, Glycolysis, Methanolysis, Hydrolysis, Gasification, Pyrolysis and Catalytic Conversion, Recycling methods, namely (primary, secondary, tertiary and quarter) recycling.
The Influence of Entrepreneurial Orientation Dimension on Supply Chain Performance at PT XYZ Jakarta in 2022
Authors: Pratiwi Sekar Widyastuti , Purwoko Harry , Akbar Ghifari Maulana , Firdaus Muhammad Iqbal , Lermatan Esterlinus Edwin
Published: February 2024

This thesis aims to analyze the influence of entrepreneurial orientation dimensions on supply chain performance at PT XYZ. The supply chain is a vital element in business, including planning, procurement, production, distribution and delivery of products/services to end consumers. Entrepreneurial orientation includes proactiveness, innovation, and risk taking. This research uses a quantitative approach with survey methods and questionnaires distributed to managers and supply chain staff. Secondary data was obtained from literature, financial reports and company documents. Analysis uses SmartPLS 3.2.9 with variance-based structural equation analysis, measuring and modeling data simultaneously. Samples were taken using a saturated sampling technique. The results show that innovation has no significant positive effect on supply chain performance, while proactiveness and risk taking have a significant positive impact. Exogenous variables (innovation, proactiveness, risk taking) explain 53.1% of supply chain performance, the rest is influenced by other factors. The implications of this research provide guidance for companies to increase supply chain efficiency in competitive and dynamic markets.
Analisis Efektivitas Penerapan Program Kebijakan Pemutihan Pajak Kendaraan Bermotor dalam Upaya Meningkatkan Pendapatan Pajak Daerah di SAMSAT Kabupaten Tegal
Authors: Patria Yoka Mai
Published: February 2024

One such policy is to increase the number of taxpayers who own motor vehicles but have not been paying taxes. To address this issue, local governments offer an option to waive administrative sanctions for motor vehicle taxes. The purpose of this research is to analyze the effectiveness of the implementation of the motor vehicle tax amnesty policy, as well as to identify obstacles and efforts to overcome these obstacles in the program’s execution. This study adopts a qualitative approach with descriptive analysis methods with secondary data as its basis. The research results indicate that the effectiveness of the motor vehicle tax amnesty policy is relatively successful, evident in the increased achievement of motor vehicle tax revenue targets at the Tegal District SAMSAT in the years 2021- 2022. Despite the increase in revenue, there was a decline in realization in 2022 compared to 2021. However, the Tegal District SAMSAT has made efforts to enhance the collection of motor vehicle tax revenue.
GEOLOGY AND CREATIVITY. GEOLOGISTS IN ART
Authors:   Vernadsky State Geological Museum RAS, Cherkasov S.V. , Dadykina-Rabinovich I.V. ,   Vernadsky State Geological Museum RAS
Published: February 2024

The article is a brief overview and analysis of the work of authors belonging to the geological professional community. The work on the “Geology and Creativity” portal, created to collect and manage information about literary, artistic, and musical works of geologists, is covered.
MAMMALS OF KHAZAR FAUNAL COMPLEX FROM THE LOST DEPOSITS OF VOLGA REGION IN THE VERNADSKY STATE GEOLOGICAL MUSEUM. HISTORY OF THE SAMPLES’ RECEIPTION AND RESEARCH.
Authors:   Vernadsky State Geological Museum RAS, Starodubtseva I.A. , Kuznetsova T.V. ,   Lomonosov Moscow State University, Basova V.B. ,   Vernadsky State Geological Museum RAS
Published: February 2024

The article represents data about Khazar faunal complex (absolute age from 0, 4 up to 0, 08 million years back), originated from the lost locations such as Mysy, Tunguz, Kostyanoy Ostrov and presumably from Khoroshevsky Ostrov (Volga region), and stored in SGM RAS funds. The article describes the history of Tunguz and Kostyanoy Ostrov locations discovery and research. The article presents data about history of receipt and research of those collections.
АCADEMICIAN VLADIMIR OBRUCHEV – THE FIRST DIRECTOR OF THE GEOLOGICAL INSTITUTE OF THE ACADEMY OF SCIENCES OF THE SOVIET UNION
Authors:   Russian Academy of Sciences, Degtyarev K.E. , Malakhova I.G. ,   GIN RAS
Published: February 2024

The article is devoted to the first director of the Geological Institute of the Academy of Sciences of the Soviet Union Vladimir Obruchev. The reasons for his election and his connection with the Institute throughout his life are considered. Attention is paid to the creation, on the initiative of Obruchev, of a new field of geosciences at the Institute – the history of geological knowledge. The work with the scientific heritage of academician Vladimir Obruchev is highlighted.
PENGEMBANGAN MODUL PEMBELAJARAN PADA MATERI METABOLISME DI SMA NEGERI 4 LUBUKLINGGAU PROVINSI SUMATERA SELATAN
Authors: Susanti Ivoni
Published: February 2024

This study aims to understand the importance of metabolis processes in organisms through the development of learning modules for students of SMA Negeri 4 Lubuklinggau. The type of research is development using the Borg and Gall develeopment model which is modified into 4 stages. After validation, the next step is to apply it to clas XII students. The results show that there are differences in student learning outcomes using the modules on fatty acid material and free fatty acid tests between before and after using the module and carrying out experiments, with the average value of the initial test (pre-test) 57,78 smaller than the average values. The final test (post-test) is 80,69 and is greater than the KKM score (70).
PENERAPAN MODEL PEMBELAJARAN INKUIRI UNTUK MENINGKATKAN HASIL BELAJAR IPS SISWA KELAS V SDN 124395 PEMATANG SIANTAR
Authors: Herlina Lina , Shafira Fauza , Purba Wendi Leonardo
Published: February 2024

Penelitian ini bertujuan untuk meningkatkan proses pembelajaran IPS  agar dapat menyenangkan dan membuat siswa menjadi aktif. Penerapan model pembelajaran inkuiri dapat meningkatkan hasil belajar IPS siswa kelas V SDN 124395. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK) dengan menggunakan model Kemmis dan Mc. Taggart, dengan subjek penelitian yaitu siswa kelas V SDN 124395 yang berjumlah 29 siswa dan objek dalam penelitian ini adalah peningkatan hasil belajar siswa pada mata pelajaran IPS. Hasil penelitian menunjukkan bahwa melalui penerapan model ikuiri dalam pembelajaran IPS dapat meningkatkan hasil belajar siswa. Peningkatan hasil belajar siswa ini dilihat dari meningkatnya kemampuan siswa dalam mencari jawaban dari permasalah melalui berbagai tahapan dalam model inkuiri yaitu orientasi, merumuskan masalah, merumuskan hipotesis, mengumpulkan dan atau informasi, melakukan uji hipotesis, merumuskan kesimpulan. Peningkatan hasil belajar siswa dilihat dari meningkatnya persentase ketuntasan hasil tes siswa dimana pada pra tindakan persentasenya 31,03%, pada siklus I meningkat menjadi 55,17%, dan meningkat lagi pada siklus II menjadi 82,76%