bluuebunny/crossref_metadata_2025 huggingface dataset:
NGA Live-Production Workflows: Personalized Audio Experience in Broadcasting
Authors: Iwasaki Taishi , Kubo Hiroki , Sugimoto Takehiro , Oode Satoshi , Nakayama Yasushige , Okubo Hiroyuki
Published: January 2025

Next-generation audio (NGA) delivers personalized audio experiences based on the listener's preference, loud-speaker configurations, and rendering algorithms in the listening environments. A prototype of NGA production equipment was arranged to verify the NGA live-production workflow and produce the typical personalized NGA programs. It consisted of our developed NGA console, NGA loudness meter, and MPEG-H 3DA-complied coding system supporting the Audio Definition Model (ADM) and the serial representation of ADM (S-ADM). Subjective tests were conducted to verify the reasonability of the loudness measurement method to develop the NGA loudness meter using several rendering conditions, including loudspeaker configurations and rendering algorithms. The results showed that the differences between objective and subjective loudness of NGA programs are comparable to those of channel-based audio programs.
APLICAÇÃO DO CONTROLE ESTATISTICO E FERRAMENTAS DA QUALIDADE EM UMA INDUSTRIA TÊXTIL DO BRASIL
Authors: Do Carmo Brendeson Carvalho , Filho Adson Brito Pinheiro , Nunes Dr. Denílson Ricardo De Lucena , Costa Vinicius Teixeira
Published: January 2025

A indústria têxtil tem grande importância na economia brasileira desde o século XVIII por servir de complemento para outras indústrias tanto para grandes, medias e pequenas empresas. Atualmente essa indústria é responsável por gerar grandes receitas, no ano de 2023 arrecadando US$ 956 milhões em exportação, registrando um faturamento de R$ 193,2 bilhões em 2022 com investimento de 4,6 bilhões. Dessa forma se faz necessário analisar os processos dessa indústria, para que haja a possibilidade de geração de dados quantitativos precisos e assim justificar o investimento em seus setores. Portanto o presente trabalho tem como objetivo monitorar o processo produtivo de uma empresa brasileira do setor têxtil, através do controle estatístico do processo (CEP) juntamente com as ferramentas da qualidade, visando apresentar o cenário atual do processo que está sendo utilizado pela empresa e gerando um panorama geral dos setores fabris estudados.
REPERCUSSÕES PERINATAIS DA SÍFILIS CONGÊNITA EM RECÉM-NASCIDOS DE UMA MATERNIDADE DE RISCO HABITUAL NO ANO DE 2020
Authors: Gropillo Carolina Gonçalves , Shimizu Letícia , Simão Melissa Hissami , Azulay Caroline Wainstein , Ornellas Marcela Reis Rico , Serra Mayco José Reinaldi , David Maria Luisa Diaz Cunha , Rullo Vera Esteves Vagnozzi
Published: January 2025

Objetivo: Avaliar as repercussões perinatais de recém-nascidos (RN) acometidos por sífilis congênita (SC) em comparação ao perfil de RN não expostos no mesmo período de tempo. Metodologia: Trata-se de um estudo de coorte histórica realizado através da coleta de dados maternos e neonatais obtidos através do Livro de Parto da Maternidade Municipal de São Vicente, uma maternidade de risco habitual da Região Metropolitana da Baixada Santista - São Paulo, durante o ano de 2020. O grupo exposição foi caracterizado pelos RN acometidos por sífilis congênita e o grupo controle pelos RN não expostos. Resultados: O grupo exposição é composto por 45 RN com SC notificada e confirmada, sendo que 80% deles apresentam baixos títulos de VDRL. Na análise das variáveis maternas, 82,22% das mães têm de 19 anos a menos de 35 anos; 66,67% realizaram menos de 6 consultas pré-natal; e somente 33,33% tiveram parto cesárea. As variáveis neonatais demonstram que 75,56% dos RN nasceram com idade gestacional (IG) entre 37 semanas e 41 semanas e 6 dias. Dentre os RN analisados, 28,89% tinham baixo peso; 20% foram classificados como PIG; e dos RN classificados como PIG, 55,56% eram proporcionados. Além disso, 44,44% apresentaram pequena estatura para IG e 26,67% obtiveram classificação de pequeno PC para IG. Quanto ao Apgar no 1º minuto, 24,44% apresentaram pontuação menor ou igual a 7 e 71,11%, entre 8 e 10; no 5º minuto, 88,89% receberam pontuação entre 8 e 10. Após o nascimento, 73,33% dos RN foram encaminhados ao alojamento conjunto e 17,78% à UTI neonatal. Conclusão: A presença de SC esteve relacionada à maior incidência de desfechos neonatais desfavoráveis, quando comparado aos não expostos, nas variáveis prematuridade, baixo peso para a IG, Apgar de 1º minuto menor que 7 e encaminhamento à UTI neonatal.
Assessing the Efficacy of Quality of Life Evaluations in the Management of Chronic Illnesses
Authors: Surath Panda Soumya , Patil Tulsidas A. , H Malathi , Bansal Shivangi , Lal Soni Shankar
Published: January 2025

Taking care of people with chronic illnesses usually needs a complex method that focuses on both improving their health and quality of life (QoL). This essay gives an in-depth look at how QoL ratings are used and how well they work in managing chronic diseases. We want to find out how to improve QoL ratings so that treatments work better and patients are happier by carefully looking at a number of different assessment tools, such as both subjective patient-reported results and objective measures. Quality of life (QoL) tests are important for learning about how chronic illnesses affect daily life, mental health, and social relationships. Our results show that patient-centered methods that take into account personal thoughts and feelings are very important for getting a true picture of how hard chronic diseases are. We also look at the link between better QoL and clinical interventions. Our findings show that customised treatment plans that include both medical and psychological parts of care are often linked to better QoL results. The paper also talks about the problems with the way QoL is currently measured, like how different measurement tools are used in different hospital situations and how there isn't any standardisation. The paper suggests a way to use technology, like electronic health records and mobile health apps, in regular quality of life tests. These tools can give us data in real time and help with long-term tracking.
Analyzing the Impact of Healthcare Educational Initiatives on the Quality of Professional Practice
Authors: Tomar Arjit , Senapati Satyabhusan , Borah Nayana , T. C Uddhav , Karpe Suraj Rajesh
Published: January 2025

Introduction: The purpose of this study is to find out if healthcare training programs can improve the level of professional work among healthcare providers. As the need for better patient care and ongoing professional development grows, educational approaches are becoming more and more seen as essential ways to give doctors more advanced knowledge and skills.Methods: Both numeric and qualitative data were used in a mixed-methods technique. We looked at 30 peer-reviewed studies that came out between 2015 and 2023 and did a meta-analysis of results linked to clinical performance and the level of patient care. Also, 50 healthcare workers who took part in these training events were interviewed in a semi-structured way.Results: The results of the meta-analysis showed that clinical skills and patient outcomes got better, and the effect size was modest (Cohen's d = 0.5). Qualitative results showed that subjects said the main benefits were more trust and more up-to-date information. When digital tools were used in training, people were more interested and remembered more of what they learnt.Conclusions: Healthcare training programs are very important for improving the standard of clinical practice. The results show that these kinds of programs should continue to get money, with a focus on using digital tools to improve learning and effects. More study needs to be done on how these teaching tools work over time and whether they can be used in a wide range of hospital situations.
The Significance of Occupational Safety in Promoting Healthcare Workforce Satisfaction and Operational Efficiency
Authors: Chandra Deo Ram , Noor Shah Uzma , Prasad Debanjana , Kumbhar Shekhar M. , Shaik Shavali T.K.
Published: January 2025

In the healthcare field, where people often have to deal with mentally and physically challenging tasks, occupational safety is a key part of creating a good work atmosphere. Not only is making sure the workplace is safe important for reducing injuries and accidents, but it also plays a big part in making the healthcare staff happier and more productive. This article investigates the links among employee satisfaction, safety procedures at work, and the performance of operations in healthcare institutions. Regarding healthcare, workers' level of happiness directly relates to the safety precautions used in their workplace. Like physicians, nurses, and related health personnel, healthcare professionals often deal with high-stress events and must tend to patients on short notice. Ignoring the correct safety guidelines may lead to fatigue, additional anxiety, and absences—directly reducing employee satisfaction. Conversely, a safe workplace helps reduce these pressures, thereby improving job satisfaction, collaboration, and staff retention rates and lowering of stress. In healthcare institutions, employment happiness and operational efficiency are intimately linked. Employees that are content and feel supported are more likely to complete their tasks properly, therefore improving patient care and service performance. Like appropriate training, ergonomic designs, and mental health support, safety precautions help healthcare teams function better generally and assist to reduce errors. Additionally, focussing on workplace safety can lower the costs of worker compensation claims, absences, and employee loss, which helps healthcare facilities run more efficiently. In this paper, the urgent need for healthcare managers to make safety at work an important part of their operating plans is emphasised. In this way, they can not only protect the health and safety of healthcare workers, but also help the organisation succeed, making sure that both employees are happy and operations run smoothly.
Learning Assisted by Artificial Intelligence Tools in College Students
Authors: Cisneros Basurto Wilson Edmundo , Chapaca Tituaña Xiomara Maribel , Pesantez García Favio Manolo , Maldonado Beltrán Alexis Hernán
Published: January 2025

In particular, the present research seeks to substantiate the topic of learning assisted by artificial intelligence tools in college students, the main objective of this research was to evaluate the benefits of artificial intelligence tools in the academic training of university students. The scope of the research focuses on a representative sample of members of the University of the Armed Forces ESPE in Santo Domingo, using artificial intelligence tools as a complement to their training. To achieve these objectives, a longitudinal study was carried out covering a period of one academic semester. Data were collected through a survey, performance tests and analysis of tool usage records. Statistical analysis and qualitative techniques were used to process the data. The results showed significant improvements in their academic performance compared to their experience in other semesters. These tools facilitate the personalization of learning, adapting to the individual needs of the students, which resulted in greater engagement with the content and greater retention of information. In addition, it was observed that artificial intelligence tools promoted collaboration and knowledge sharing among students. The main findings of this research indicate that their incorporation in higher education can be highly beneficial. This research underscores the importance of considering the integration of artificial intelligence as a valuable resource for higher education in the digital age.
A INTELIGÊNCIA ARTIFICIAL NO PODER JUDICIÁRIO BRASILEIRO
Authors: Cruz Paula Beatriz Lima , Souza Patrícia Verônica Nunes Carvalho Sobral de
Published: January 2025

Com o avanço das ferramentas de IA, especialmente no Judiciário, surge a questão sobre a possibilidade de sua utilização na tomada de decisões judiciais automatizadas e os potenciais riscos de violação dos direitos fundamentais garantidos pela Constituição de 1988 e legislações correlatas. O trabalho visa explorar os impactos da inteligência artificial (IA) nos direitos individuais e coletivos, particularmente no contexto jurídico brasileiro. Dividido em três capítulos, o estudo aborda inicialmente os aspectos da IA e sua aplicação, seguido pela análise dos direitos individuais e coletivos. O terceiro capítulo se dedica a examinar como as aplicações da IA podem afetar esses direitos, destacando preocupações éticas e a necessidade de preservar a sensibilidade humana e a justiça equitativa. A metodologia adotada é qualitativa, utilizando revisão bibliográfica e documental, incluindo jurisprudência relevante. Espera-se alcançar um equilíbrio entre o uso da tecnologia e a proteção dos valores democráticos e dos direitos fundamentais, essenciais para uma sociedade inclusiva e justa.
Factores sociodemográficos de niños en edad preescolar para identificar sobrepeso u obesidad
Authors: Nájera Gutiérrez Gudelia , Sánchez Pérez Osbelia , Morales Rodríguez María Claudia , Resendiz Maldonado Brenda
Published: January 2025

El sobrepeso y la obesidad se definen como una acumulación anormal o excesiva de tejido adiposo, lo que puede tener repercusiones adversas en la salud, especialmente en la infancia. Según datos de la OMS, en 2016 se estimó que 41 millones de niños menores de 5 años en el mundo sufrían de sobrepeso u obesidad. Anteriormente, se creía que estas condiciones eran prevalentes principalmente en países de altos ingresos; sin embargo, en la actualidad, se observa un aumento significativo en naciones de ingresos bajos y medianos, especialmente en áreas urbanas. Generar evidencia que apoye la práctica de la enfermería, enfocándose en la promoción de la salud a través de intervenciones dirigidas a cuidadores y niños menores de 5 años, con la intención de prevenir enfermedades crónico-degenerativas. Se realizó un estudio cuantitativo, descriptivo y transversal en un Jardín de Niños con una población total de 113 niños que asistieron regularmente al Jardín de Niños durante el periodo de evaluación.  Este hallazgo coincide con estudios previos que indican un aumento de la obesidad infantil en contextos urbanos y rurales, lo que resalta la necesidad de enfoques adaptados a las características específicas de cada comunidad. La evaluación realizada justifica la implementación de intervenciones educativas personalizadas que respondan a las necesidades específicas de esta población infantil. Estas acciones contribuirán significativamente a reducir los riesgos asociados con el sobrepeso y la obesidad, al tiempo que garantizarán un desarrollo infantil adecuado y saludable.
Development Strategy in Increasing Tourist Visits in Cemagi Tourist Village
Authors: Ganang Aditiyo Prakoso  , Marmaiyatno  , Baskoro Harwindito
Published: January 2025

Purpose: Determine the internal and external factors that support and hinder development in Cemagi Tourism Village and Determine the best alternative strategy analysis for Cemagi Tourism Village.
Research methods: This research uses a qualitative approach. The sampling technique used in this research is purposive sampling. The data analysis used in this research is SWOT.
Results and discussion:The results of this research are the strategies that can be implemented in developing the Cemagi Tourism Village to increase the number of tourist visits, including: (1) SO Strategy: Creating Cemagi trek tour packages, agrotourism and cultural tourism, and making promotions about Cemagi's tourism; (2) WO Strategy to improve infrastructure or create infrastructure that supports tourism in Cemagi; (3) ST Strategy: Creating a different program from other tourist villages; (4) WT Strategy Create a village security program.
Implication: Based on the results and discussion of this research, the researcher recommends implementing the strategies that she has created, such as improving the existing infrastructure in the Cemagi Tourism Village. The tourist village should be more aggressive in its promotion, especially on social media. It would be better to collaborate with travel agents when selling tour packages. Collaborate with the government to create an event that can attract tourists to the Cemagi Tourism Village.
Formulation, development and optimization of ofloxacin FDDS sustained release for UTI and H. pylori
Authors: Afnan Muhammad , Shakeel Hamza , Mustafa Ghulam , Akram Waseem , Husain Talib
Published: January 2025

Objective: Development & Optimization of Ofloxacin Floating tablets to enhance gastric retention time. Sustained release effect of formulation will reduce the dosing frequency for UTIs and prolonged local effect will benefit against H-pylori infection. Materials: Pre formulation tests were performed which include bulk characteristics and flow properties. Post formulation studies include weight variation, thickness, content uniformity, hardness, friability, dissolution studies, release kinetics and compatibility & stability analysis. Kinetic studies were done and models were applied to understand the drug release mechanism. Accelerated stability analysis was also done for time period of 6 months. Results: All pre formulation tests were within range of USP standards, all the formulations showed good buoyancy. The in-vitro dissolution testing showed that F2 released drug at much slower rate, 64.97% within 24 hrs. F3 & F4 released ofloxacin at faster rate, 98.6% & 99.90% respectively, however, F1 released 91.66% drug within 24 hrs. F1 followed Higuchi model, F2 & F3 followed 1st order kinetics and F4 followed 1st order & Higuchi model. For F1, FTIR & DSC analysis curves showed no interaction or change of state of ofloxacin. Conclusion: Formulation F1 was proved to be the optimized formulation and followed non-Fickian release independent of concentration of drug also confirmed from Korsmeyer-Peppas equation. The Stability analysis also proved that F1 is the best fit formulation to be used as Floating Drug Delivery System of Ofloxacin. Stability analysis proved that polymers used in F1 formulation were effective effervescent agents and made the formulation optimized and efficacious.
Association of restless leg syndrome with fatigue and sleep quality among students taking paracetamol
Authors: Rehman Ayesha , Karim Ayesha , Ejaz Muhammad , Imran Hunsha , Iqbal Zunaira , Aslam Rimsha
Published: January 2025

Objective: Restless leg syndrome is a major condition experienced by many individuals and is mostly present in medical undergraduates it is mostly found in correspondence with fatigue and sleep and many other factors as well. The objective of this research is to examine the correlation between restless leg syndrome (RLS) and insomnia within the population of medical students. Methods: The inquiry is a sampling pattern of a cross-sectional study and sampling is done with a convenience sampling technique. To diagnose Restless Leg Syndrome, International Restless Legs Syndrome Study Group Diagnostic criteria are used, as well as fatigue and sleep quality are assessed by Fatigue Severity Scale and Pittsburgh Sleep Quality Index respectively. The responses from the participants were taken in the form of a Questionnaire. Statistical Package for Social Sciences (SPSS) is used to find out the interaction of restless leg syndrome with sleep and fatigue in medical undergraduates. The gathered data was evaluated over SPSS. The data was collected from 178 medical students both female and male mainly ranging from 18 to 26 years. Intervention: The data collection is done by International Restless Legs Syndrome Study Group Diagnostic criteria, Fatigue Severity Scale, and Pittsburgh Sleep Quality Index. The study is mainly conducted to raise awareness about restless leg syndrome in students and its correlating factors i.e. Poor sleep and fatigue. Results: This research contains 178 respondents. The mean age of respondents was 20.80 ±1.692 years with 36 (20.2%) being males and 142 (79.8%) being females. Sleep disturbance was observed in 80.9 % of the total population and fatigue was present in 53.4% of the total population. Restless Leg Syndrome was also so frequently present (36%) in medical students. Conclusion: The statistical analysis showed that restless leg syndrome was common in medical students and is most significantly correlated with fatigue and Sleep disturbance among medical undergraduates of Lahore Institute of Science & Technology with statistically significant (p=0.04) and (P=0.011) respectively.
Preparation of skin friendly topical gel containing betamethasone dipropionate loaded ethosomes and salicylic acid for the treatment of eczema
Authors: Azhar Aleesha , Aamir Muhammad Naeem , Khan Safiullah , Shehzadi Kiran
Published: January 2025

Ethosomes, a lipid-based vesicular system, are a cutting-edge method for delivering medicinal drugs transdermally for either local or systemic action. Betamethasone Dipropionate ethosomes were fabricated and then these were incorporated into the final gel containing salicylic acid. Betamethasone is an anti-inflammatory agent and salicylic acid acts as a keratolytic agent. The increased drug entrapment and permeation are caused by the high ethanol content of ethosomes. By changing the proportions of ethanol and lipoid S100 in a cold method, ethosomes were created. The concentration of ethanol utilized ranged from 30 to 40%, whereas the concentration of phospholipids ranged from 3 to 5%. The characteristics of ethosomes made with 40% ethanol and 3% Lipoid S100 were improved. The size, zeta potential, entrapment efficacy, in-vitro release profile, ex-vivo skin permeation study, plus in-vitro stability investigations of the prepared Betamethasone Dipropionate ethosomes were all assessed. With an average size of 220-240nm, entrapment efficiency was 81.42-91.65%%, zeta potential was -12.91 to -14.42, and its in-vitro cumulative drug release over 12 hours was 96%. The drug penetration from the ethosomes gel formulation through the rat skin was two times more than that of the Betamethasone control gel. Ethosomes gel's rheological behaviour was evaluated, and pseudo plastic flow behaviour suggested that the formulation was suitable for topical use. Moreover, the formulations were stable at 8 °C and the ethosomes formulation demonstrated improved drug penetration through the epidermal membrane, improving the medication's bioavailability.
A short review on poliomyelitis: Types, transmission, diagnosis, prevention, treatment
Authors: Marzia Ayna , Ali Liaqat
Published: January 2025

This research is focused on the impact of poliomyelitis in current era. It also explores strategies for its prevention and control. The study utilizes qualitative research methods to comprehensively explain and support interpretive goals. Secondary data sources are used for data collection. The disease is highly contagious and can spread rapidly, especially in areas with inadequate sanitation and low vaccination rates. The symptoms of polio vary from mild flu-like symptoms to severe paralysis, with some cases resulting in lifelong disability or death. Vaccination is the most effective means of preventing polio. The oral polio vaccine (OPV) and inactivated polio vaccine (IPV) have played a crucial role in reducing the global burden of the disease. Reinforcing healthcare systems: Polio eradication endeavors can contribute to the enhancement of overall healthcare systems, including surveillance, laboratory networks, and vaccine delivery systems. This can have broader benefits for other immunization programs and public health interventions. Collaboration and coordination: Continued cooperation among countries, international organizations, and stakeholders is essential in tackling the remaining challenges and ensuring a synchronized global response to polio eradication. Through united global efforts and unwavering dedication, the vision of a polio-free world can be achieved, safeguarding future generations from this devastating disease.
A cross-sectional study on treatment and preventive measures of dengue fever
Authors: Siddiqui Sidra , Maqbool Tahmina , Shyum Naqvi Syed Baqir , Zaheer Kamran , Khan Sarah Jameel , Siddiqui Sana
Published: January 2025

Objective: The Arbovirus known as dengue belongs to the Flaviviridae class. Asymptomatic to severe illnesses (dengue haemorrhagic fever/dengue shock syndrome) are the clinical spectrum of its expression. Despite the fact that this condition has been subject of extensive investigation, there is currently no cure. The goal of current study was to describe socioeconomic determinants and knowledge, attitude, and practice status of dengue treatment among population of Pakistan. Methods: From March 2023 to January 2024, cross-sectional survey involving 252 randomly chosen participants from various regions of Karachi were carried out. Systematic questionnaire was utilized to gather information about participant’s sociodemographic traits and their understanding of dengue fever and their practices for treating it. Factors related to awareness and comprehension of dengue were looked into independently by using IBM SPSS Statistics 20. Results: The majority of respondents were aware of dengue, yet they continued to have false beliefs about the areas where Aedes breeds. Misconceptions about Aedes breeding in unclean water were held by around half of the survey participants, and some were aware that Aedes bites most frequently at dawn and dusk. The level of preventative activity was marginally lower than the level of knowledge, despite a substantial (p<0.05) correlation between the two. Conclusion: As dengue spreads in Pakistan, it is critical to step up health promotion efforts by launching campaigns to dispel widespread misconceptions and information gaps regarding the disease and its treatment.
Formulation and evaluation of mucoadhesive gastro-retentive tablets of domperidone
Authors: Abdullah Drakhshaan , Saeed Rabia , Ali Maria , Sohail Mahum , Naeem Sumiya , Hussain Talib
Published: January 2025

Objective: This study was aimed at the formation and evaluation of the mucoadhesive gastro-retentive tablet of domperidone to overcome the drawbacks related to the oral administration of drugs. These gastro retentive formulations stay in the stomach for a longer time to provide prolonged gastric retention time. Methods: Mucoadhesive tablets were prepared by using Carbopol 940, sodium alginate, HPMC, and other polymer combinations in five formulations. Before tablet preparation, pre-formulation studies were performed i.e., bulk characterization, crystallinity, hygroscopicity, micrometric properties, melting point, particle size distribution, solubility, and stability analysis. The method of wet granulation was used for the formation of mucoadhesive gastro-retentive tablets of domperidone. Five formulations were evaluated for physical parameters using official methods mentioned in USP pharmacopeia, mucoadhesive strength & time, and swelling index. The USP-II dissolution apparatus with 1.2 HCl buffer was used for performing an in-vitro dissolution study for 24 hours. The optimized formulation was evaluated for compatibility studies using FTIR and DSC studies. Results: Among the five formulations the F5 was the optimized formulation because of its drug content, mucoadhesive strength, in-vitro drug release, and swelling index (7hr) of the optimized formulation 95.92 ± 0.62%, 26.98 ± 1.0gm, 93.16%, and 3.673% respectively. The release kinetics indicated that the F3 to F5 followed Higuchi’s equation and non-fickian release which means F5 was dependent on both diffusion and dissolution thus the system is both diffusion and dissolution controlled. The resultant peaks of FTIR and DSC studies showed almost no drug-polymer interaction, which indicated physiochemical compatibility of drug and polymer in the optimized formulation. Conclusion: Hence concluded that the F5 was an optimized formulation that contained 84gm of Carbopol 940 and was found suitable for all performed evaluating parameters.
Fabrication and characterization of colon targeted ibuprofen nanoparticles
Authors: Riaz Ayesha , Shaukat Areej , Farooq Umar , Ashraf Zunaira , Fatima Ishrat , Hussain Talib , Arshad Waqas , Sheikh Fatima Abkar
Published: January 2025

Aim: The objective of our study was to formulate a nanoparticulate drug delivery system that provides controlled delivery of ibuprofen directly targeting colon leading to optimized dosage, reduced side effects ultimately increasing bioavailability and to explore formulation optimization parameters. Methodology: Colon targeted ibuprofen nanoparticles were prepared by solvent evaporation method. Analysis of formulation was performed for surface morphology, percentage entrapment efficiency, particle size, zeta potential, content uniformity, in vitro drug release and Stability assessment. Result: The ultimate optimized conditions found were 1500rpm, 0.1% W/V Tween 80 stabilizer and 1:10 organic to aqueous ratio. Among 6 formulations of ibuprofen nanoparticles analyzed, F1 (with 0.1% Tween 80 stabilizer) was found to be optimized with highest percentage release 99.64%, mean particle diameter 586 nm, smooth surfaces, 88.36% encapsulation efficiency, zeta potential-49mV and controlled release of drug over 8 hours. Conclusion: The optimized stable formulation F1 results showcased that 1500 rpm, 0.1% W/V Tween 80 stabilizer and 1:10 organic to aqueous ratio are optimized parameters of colon targeted ibuprofen nanoparticles preparation with formulation being cost effective with its remarkable enhancement of bioavailability.
Improving paclitaxel delivery: Liposomal encapsulation for enhanced solubility, stability and targeted therapy
Authors: Shahid Muhammad Awais , Khan Muhammad Afzal Hussain , Wazhi Muhammad , Hussain Talib , Javed Muhammad , Fraz Muhammad , Ali Saba
Published: January 2025

Background: Paclitaxel, a potent anti-neoplastic agent, finds application in treating various malignancies like breast, ovarian, lung, and pancreatic cancers. However, paclitaxel's hydrophobicity renders it poorly soluble in water, hindering its therapeutic efficacy. Originally isolated from the Pacific Yew tree (Taxus brevifolia) in the 1960s, it has become a cornerstone of cancer treatment. Liposomes offer a promising strategy to address paclitaxel's solubility limitations. These microscopic vesicles, composed of lipid bilayers, have the potential to improve drug antitumor efficacy. Objectives: This study investigated the potential of liposomal encapsulation to: Improve the solubility and stability of paclitaxel, enable targeted delivery for a more precise therapeutic approach, potentially enhancing paclitaxel's therapeutic index. Methods: Five liposomal encapsulation of paclitaxel was achieved using the thin film hydration method with a rotary evaporator. Pre-formulation studies were conducted to assess paclitaxel's suitability for liposomal formulation. These included physical examination, melting point determination, solubility analysis and UV-visible spectral analysis for determining the absorbance maximum. Additionally, Differential Scanning Calorimetry (DSC) was employed to evaluate compatibility between the drug and excipients. Results: The liposomes had a mean particle size of 92.4±0.238 nm, an entrapment efficiency of 87.2±0.504 and acceptable drug loading of 7.654±0.49. The liposome is best stored at 40 C and has melting point of 2160 C. The solubility analysis is carried through UV spectrophotometer. The in vitro dissolution of formulation is carries out with help of dd solver and kinetic parameters were employed namely zero order, first order, Higuchi and Korsmeyer Pappas were employed. The Korsmeyer-Peppas is best fit and n values around 0.6. The stability analysis was carried with DSC which shows to be compatible with polymers below 1000 C and degradation above 1000 C. Conclusion: Liposomal formulations hold significant promise in cancer therapy due to their biocompatibility and low toxicity profile.
El tratamiento de las agresiones sexuales cometidas por menores en la legislación española
Authors: Cardenal Montraveta Sergi
Published: January 2025

El trabajo expone y analiza el tratamiento de las agresiones sexuales cometidas por menores en la legislación española tras la entrada en vigor de las últimas reformas de esta materia. Se destacan las insatisfactorias consecuencias derivadas de su consideración como delitos graves sometidos, en la mayoría de los casos, a las reglas previstas en el art. 10.2 de la Ley Orgánica de Responsabilidad Penal de los Menores (LORPM) para los delitos de máxima gravedad.
Procedimiento abreviado en el Sistema Integral de Justicia Penal para Adolescentes
Authors: Ramírez Valdés Edgar
Published: January 2025

Este artículo ofrece un estudio relacionado con el procedimiento abreviado en el Sistema Integral de Justicia Penal para Adolescentes en México. Hoy en día se desconocen los alcances de la figura del procedimiento abreviado en adolescentes; se confunde con la solución alterna al conflicto, lo que no debe ser así. El procedimiento abreviado fue creado para despresurizar los centros penitenciarios para personas adultas, y se ha buscado implementarlo con adolescentes, lo cual no es correcto, porque dicho procedimiento fue diseñado para adultos, no para adolescentes.
Justicia para adolescentes en México
Authors: Cobo Téllez Sofía Magdalena
Published: January 2025

El artículo analiza la evolución del Sistema Integral de Justicia para Adolescentes (SIJPA) en México, desde el cambio de paradigma del sistema tutelar al de protección integral. Se destaca la importancia de la especialidad y especialización, así como la necesidad de abordar la justicia para adolescentes desde una perspectiva sistémica, integral e interdisciplinaria. Se examinan los principios rectores del SIJPA, como el interés superior, protección integral y autonomía progresiva, y se enfatiza la necesidad de considerar los contextos de las personas adolescentes de manera holística.
‘My Two Lassies:’ Enslaved Children and the Creation of Family Narratives in British East Florida and Aberdeenshire
Authors: Osborne Désha Amelia
Published: January 2025

In 1783 Margaret and Sophia Ross were transportedby their father John Ross from the short-lived colony of British East Florida to live with relatives in Aberdeenshire, Scotland. Born into slavery like their mother Bella, the girls were manumitted before being sent to live with their grandfather, the Laird of Arnage. Their experiences, and their relationships with their Aberdonian relatives have until now remained conspicuously concealed in the archives in the Special Collections Library at the University of Aberdeen. Personal letters, journals, and testaments – in addition to records found in other archives in the United Kingdom, United States and the Caribbean – reveal the worlds of two among the many hundreds of marginalised ‘natural or reputed’ children lost to both memory and the historical record. Does their absence from official published history suggest an intentional and calculated deletion of their presence from the family story? 
The “Practitioner of Physick and Surgery” and the Enslaved “Doctor”: Medicine, Slavery, Race, and Patriarchy in the Eighteenth-Century Jamaica
Authors: Mitchell Elise
Published: January 2025

In 1773, Alexander Johnston, a Scottish ‘Practitioner of Physick and Surgery’ in St. Ann, Jamaica, made a list titled ‘my slaves’. Beside the name ‘Galen’ he wrote ‘a Doctor’. Galen was the only enslaved person Johnston ever recognised with that title. Many slave owners called the people they enslaved and tasked with attending ill enslaved people, ‘Doctor’, ‘Doctress’, or ‘nurse’. Johnston’s records reveal that he sent Galen away to train under another white doctor before assigning him that role. Johnston and Galen both lived in a time when medical labour and expertise were increasingly masculinised in Jamaica. Juxtaposing the histories of the Alexander Johnston and Galen provides insights into how racialised notions of masculinity created and foreclosed opportunities to become a medical practitioner or healer in eighteenth-century St. Ann, Jamaica. Tracing Johnston and Galen’s parallel migrations, careers, and legacies reveals devastating truths about the ways middling Scotsmen and doctors, like Johnston, enhanced their masculinity by exploiting the enslaved and how enslaved African men healers were simultaneously incorporated and marginalized within early British colonial medical practise.
The Gordons of Cairness and the Gordons of Cluny: Some Legacies of Caribbean Slavery in North East Scotland.
Authors: Short Alan Wilson
Published: January 2025

This paper is a preliminary, archive-based study of two unrelated Gordon families and some of the legacies of their slave derived-wealth in North East Scotland. In the case of the Gordons of Cairness, the family’s wealth from their Jamaican sugar income in the 1780’s and 1790’s, played a significant part in propelling the family into the front rank of the North East’s non- titled landed families, helping to fund architectural, educational and economic developments around their Cairness estate as well as subsidising Major General Thomas Gordon’s involvement in the Greek Wars of Independence in the 1820’s. In the case of the Gordons of Cluny, wealth from the family’s Tobago plantations supplemented the Cluny rental income contributing to the redevelopment of Cluny castle and estate and to the purchase of the islands of South Uist, Benbecula and Barra in the Outer Hebrides. As the historiography of Scotland’s links to slavery in the Caribbean increasingly places enslavement at the centre of our understanding of the nation’s economic progress in this era, research on the lives of the enslaved becomes a powerful tool for the public understanding of ‘Scotland’s Empire’. A small number of ‘slave registers’ in the Gordon of Cairness family papers, reveal themes of agency, endurance and resistance. The names of the enslaved help to remind us that the North East’s colonial connections intersect not only with the people of the Caribbean but with West Africans too.
'Aye, It Wis Aabody': Reflecting on the links of a rural Aberdeenshire Parish to Caribbean slavery
Authors: Loftus Siân , Younie David , Haslam K. , Haslam K.
Published: January 2025

The Old School in the historic parish of Birse in the North East of Scotland, presents as a modest rural Victorian building, but contains fabric from an original school constructed in the 1730s. During consideration for the future of the site, it was recognised that the school owed its establishment to a legacy in the will of Rev. Gilbert Ramsay in the early eighteenth century. Even a cursory examination establishes that Ramsay's life, and wealth, were intricately interlinked with the trade in enslaved people and that, via Ramsay's financial support, the residents of the parish of Birse have been the beneficiaries of the proceeds of Caribbean slavery. A community project, which took place in 2018 and 2019 and was entitled 'Aye, it was Aabody', was set up to explore Birse, and Scotland's, links with slavery in the Caribbean via Gilbert Ramsay's legacies and to ensure that any knowledge gained was shared with the local community through a series of community events and activities. This article outlines some of the key findings of the project's research but also higlights some of the benefits and challenges of a community-led heritage project, and the role that local communities can play, particularly when supported by academic scholars, in uncovering and disseminating the legacies of Caribbean slavery in their own parishes.
Forms as Objects of Thought in Aristotle’s On Ideas
Authors: Gonzalez-Varela Edgar ,   Philosophy Documentation Center
Published: January 2025

The argument from thinking in Aristotle’s On Ideas deals with the problem of ‘presence in absence’. It argues that, to solve it, one must posit Forms. Scholars claim that Aristotle takes the argument as valid either for Forms or for his own universals. I argue against both alternatives, for Aristotle thinks that the problem that motivates the argument does not require a metaphysical solution, but only a psychological solution.
Rancang Bangun Aplikasi Sistem Informasi Geografis untuk Pencarian Bengkel Resmi Honda di Kota Depok Berbasis Android dengan Metode Location-Based Service (LBS)
Authors: Farhan  , NM Faizah  , Koryanto Lucky
Published: January 2025

For modern society, motor vehicles have become the main mode of transportation. Regular vehicle maintenance is very important to maintain its performance and ensure safety while driving. However, many people have difficulty finding the nearest authorized Honda repair shop. The purpose of this study is to produce an android-based application that will help users find authorized Honda repair shops using the Location Based Service (LBS) method. This application will help find repair shops, check the accuracy of the repair shop location, and help raise awareness of the need to service vehicles at authorized repair shops. System development process Extreme programming consists of planning, designing, coding, and testing stages. The APP was developed from Android studio, Google Firebase, GPS, LBS. The test results show that this application can help users find the nearest authorized Honda repair shop, provide accurate address information, working hours, and repair shop contacts. This application also provides booking and navigation services to the repair shop. By using LBS, customers can contact the repair shop without having to waste time looking for the repair shop location first. This application is expected to increase the loyalty of Honda motorcycle owners to use authorized Honda repair shop services and increase awareness of the importance of routine vehicle maintenance
Consequence for the Partition (9,9,3)
Authors: Hassan Estbraq Fleeh , Jasim Niran Sabah , Yasin Mohammed , Issa Ahmad , Abo garara Samira moftah
Published: January 2025

Let  be a free module defined on the commutative ring  with identity. Buchsbaum studied the Weyl module resolution where the Weyl module  is the image of the Weyl map  for the skew-partition  ; where  runs over all partitions . There are a number of classical formulas that express the formal character of the representation  in terms of standard symmetric polynomials. Such formulas are also valid for the more general representation modules  associated to skew partition ; where , where the set of all irreducible polynomial representations of general linear group  of degree  is described by the module  
For the partition (9,9,3) by applying the boundary maps we reduction the terms of the characteristic-free of Weyl module resolution to the terms of the Lascoux resolution and prove that the sequence of the reduction terms is exact.
Fuzzy Soc–Small Two-Absorbing Modules and Related Concepts
Authors: Hanoon Wafaa H. , Salman Mustafa B. , KHAOLA ABDULHAMID SALEM
Published: January 2025

This study presents the fuzzy socle small two-Absorbing module and compares it to other fuzzy modules, including fuzzy small prime, fuzzy small two-Absorbing, and fuzzy two-Absorbing. Numerous aspects found during the investigation and discussion supported the new ideas, which fall within the fuzzy hollow, fuzzy chain, and fuzzy multiplication module classes. Discuss the connection between this concept and the fuzzy socle small two-Absorbing ideal. To create a new fuzzy socle small two-Absorbing, these findings are required.
Pengaruh Terpaan Berita Di Media Tentang Izin Tambang Terhadap Reputasi Organisasi Muhammmadiyah Di Kalangan Pemuda Muhammadiyah
Authors: Alaudin Irfan Dhiya
Published: January 2025

Penelitian ini bertujuan untuk mengkaji pengaruh terpaan berita mengenai izin tambang terhadap reputasi organisasi Muhammadiyah, khususnya dari perspektif mahasiswa Ikatan Mahasiswa Muhammadiyah (IMM) di Universitas Muhammadiyah Magelang. Di era media baru, berita yang disajikan oleh platform digital seperti Detik.com memiliki pengaruh yang signifikan terhadap persepsi publik. Teori Stimulus-Organism-Response (S-O-R) digunakan untuk memahami bagaimana berita mengenai izin tambang dapat mempengaruhi respons kognitif, afektif, dan konatif mahasiswa terhadap reputasi Muhammadiyah. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei, di mana data dikumpulkan melalui kuesioner dengan skala Likert. Sampel penelitian terdiri dari 100 mahasiswa IMM yang telah terpapar berita terkait izin tambang di Detik.com. Analisis data dilakukan menggunakan uji validitas dan reliabilitas, serta analisis regresi linear untuk mengetahui pengaruh terpaan berita terhadap persepsi mahasiswa. Hasil penelitian menunjukkan bahwa frekuensi, durasi, dan atensi terhadap berita izin tambang berpengaruh signifikan terhadap persepsi mahasiswa tentang kredibilitas, kepercayaan, keandalan, dan tanggung jawab Muhammadiyah. Penelitian ini juga menemukan bahwa sikap pro-kontra terhadap keputusan Muhammadiyah untuk terlibat dalam bisnis tambang memengaruhi reputasi organisasi di mata mahasiswa. Temuan ini memberikan kontribusi penting bagi pengelolaan reputasi organisasi di era media baru, terutama dalam menghadapi isu-isu sensitif seperti izin tambang yang dapat memengaruhi persepsi publik.
Grand Paris, une histoire de gares en lien avec les grands événements, des Expositions Universelles aux Jeux Olympiques et Paralympiques
Authors:   AHTTEP – Architecture Histoire Techniques Territoires Patrimoines de l’UMR AUSser, Vajda Joanne
Published: January 2025

This article aims to show the links between the construction of stations and major events in the Paris metropolis, through the example of three stations now located in the Grand Paris, which allow parallels between the construction of transport infrastructure for the Universal Exhibitions, the 1924 Olympic Games and the Olympic and Paralympic Games that took place 100 years later. On the one hand, we will see how these major events make it possible to rethink mobility in the Grand Paris, and on the other hand, to what extent a station built for the 1878 Universal Exhibition, the one in Colombes which was used for the 1924 Olympic Games or the one in Saint-Denis Pleyel, located near the Athletes’ Village and other infrastructures that are used for the 2024 Olympic and Paralympic Games, contribute to the transformation of the territories where they are located and find their place in the reconfiguration brought about by the construction of the new Grand Paris Express metropolitan transport network. We will see to what extent the undertaken projects concern broader urban developments, generate programmatic reflections and promise ambitious architectural approaches, which also reflect political visions. The construction of the new Saint-Denis Pleyel transport hub, presented as capable to transform the territory of Plaine Commune where the youngest and most precarious population of the Ile-de-France currently lives, has required complex engineering structures, generated the construction of new parts of the city (which require enormous financial investments) and has undergone developments that could make the Pleyel district a desirable place in the Grand Paris.
DEFINITION OF TIME: FROM THE SECOND TO CONSTRUCTAL LAW
Authors: LUCIA UMBERTO , GRISOLIA GIULIA
Published: January 2025

One of the open problems in Physics is the analytical definition of time. This paper addresses a possible answer to this topic by proposing an analytical definition of time obtained by the Second Law of Thermodynamics and the Constructal Law approach.