Preparation of Aspirin Nanosuspension by Antisolvent Precipitation Method
Authors: Van Khanh Nguyen , Van Thuong Vu , Thanh Hai Nguyen , Anh Tuan Hoang 
Published: July 2022

This study aims to enhance the dissolution rate of a poorly-soluble drug, aspirin, by fabricating aspirin nanosuspensions using the anti-solvent precipitation. The  study investigates the effect of the type of solvents, solvent to anti-solvent ratio, drug concentration, machines, stirring speed, ultrasonication technique and the temperature of solvent on the particle size and polydispersity index. The characterization of the original aspirin powder and nanoparticles was evaluated by differential scanning calorimetry and in vitro dissolution test. The results indicate that the selected formulation showed the smallest mean size of 228.2 ± 24.6 nm and a zeta potential of - 40.3 ± 2.5 mV. The differential scanning calorimetry analysis demonstrates that aspirin nanoparticles possessed lower crystallinity than the raw aspirin powder. The dissolution of nanoparticle was significantly higher compared with the original drug in the in vitro dissolution test.
Keywords: Aspirin, nanosuspension, anti-solvent precipitation, differential scanning calorimetry, dissolution.
References
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