bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Surface Plasmon Resonance Biosensor for the Rapid Detection of Botulinum Neurotoxins
Authors: Patel Kruti , Halevi Shmuel , Melman Paul , Schwartz John , Cai Shuowei , Singh Bal
Published: August 2017

Botulinum neurotoxins (BoNTs) are Category A agents on the NIAID (National Institute of Allergy and Infectious Diseases) priority pathogen list owing to their extreme toxicity and the relative ease of production. These deadly toxins, in minute quantities (estimated human i.v. lethal dose LD50 of 1–2 ng/kg body weight), cause fatal flaccid paralysis by blocking neurotransmitter release. The current gold standard detection method, the mouse-bioassay, often takes days to confirm botulism. Furthermore, there are no effective antidotes known to reverse the symptoms of botulism, and as a result, patients with severe botulism often require meticulous care during the prolonged paralytic illness. To combat potential bio-terrorism incidents of botulinum neurotoxins, their rapid detection is paramount. Surface plasmon resonance (SPR) is a very sensitive technique to examine bio-molecular interactions. The label-free, real-time analysis, with high sensitivity and low sample consumption makes this technology particularly suitable for detection of the toxin. In this study, we demonstrated the feasibility in an assay with a newly designed SPR instrument for the rapid detection of botulinum neurotoxins. The LOD (limit of detection) of the Newton Photonics (NP) SPR based assay is 6.76 pg/mL for Botulinum Neurotoxin type A Light Chain (BoNT/A LC). We established that the detection sensitivity of the system is comparable to the traditional mouse LD50 bioassay in BoNT/A using this SPR technology.
Validation Study of Italian Version of Inventory for Déjà Vu Experiences Assessment (I-IDEA): A Screening Tool to Detect Déjà Vu Phenomenon in Italian Healthy Individuals
Authors: Mumoli Laura , Tripepi Giovanni , Aguglia Umberto , Augimeri Antonio , Baggetta Rossella , Bisulli Francesca , Bruni Antonella , Cavalli Salvatore , D’Aniello Alfredo , Daniele Ornella , Di Bonaventura Carlo , Di Gennaro Giancarlo , Fattouch Jinane , Ferlazzo Edoardo , Ferrari Alessandra , Giallonardo Annateresa , Gasparini Sara , Nigro Salvatore , Romigi Andrea , Sofia Vito , Tinuper Paolo , Vaccaro Maria , Zummo Leila , Quattrone Aldo , Gambardella Antonio , Labate Angelo
Published: August 2017

The Inventory Déjà Vu Experiences Assessment (IDEA) is the only screening instrument proposed to evaluate the Déjà vu (DV) experience. Here, we intended to validate the Italian version of IDEA (I-IDEA) and at the same time to investigate the incidence and subjective qualities of the DV phenomenon in healthy Italian adult individuals on basis of an Italian multicentre observational study. In this study, we report normative data on the I-IDEA, collected on a sample of 542 Italian healthy subjects aging between 18–70 years (average age: 40) with a formal educational from 1–19 years. From September 2013 to March 2016, we recruited 542 healthy volunteers from 10 outpatient neurological clinics in Italy. All participants (i.e., family members of neurological patients enrolled, medical students, physicians) had no neurological or psychiatric illness and gave their informed consent to participate in the study. All subjects enrolled self-administered the questionnaire and they were able to complete I-IDEA test without any support. In total, 396 (73%) of the 542 healthy controls experienced the DV phenomenon. The frequency of DV was inversely related to age as well as to derealisation, jamais vu, precognitive dreams, depersonalization, paranormal activity, remembering dreams, travel frequency, and daydreams (all p < 0.012). The Italian version of IDEA maintains good properties, thus confirming that this instrument is reliable for detecting and characterising the DV phenomenon.
Significance of microRNAs in Androgen Signaling and Prostate Cancer Progression
Authors: Takayama Ken-ichi , Misawa Aya , Inoue Satoshi
Published: August 2017

The androgen receptor (AR) plays important roles in prostate cancer development and prostate tumor growth. After binding to androgens, AR functions as a nuclear receptor and translocates to the nucleus to bind to specific AR-binding sites (ARBSs). AR regulates epigenetic factor recruitments to activate its downstream signaling. Although androgen deprivation therapy (ADT) is initially useful for prostate cancer patients, most patients eventually show resistance with hormone-refractory prostate cancers (HRPCs) or castration-resistant prostate cancers (CRPCs). Thus, new therapeutic strategies targeting HRPCs/CRPCs should be very important for clinical medicine as well as prostate cancer biology. Past studies have shown that mechanisms such as AR overexpression, hypersensitivity, variants and reprograming are responsible for developing HRPCs/CRPCs. These findings suggest that AR target genes will be major key factors. In this review article, we focus mainly on the androgen-regulated microRNAs (miRNAs) to summarize the contribution of miRNA-mediated pathways for prostate cancer progression.
Characterization of Urban Heat and Exacerbation: Development of a Heat Island Index for California
Authors: Taha Haider
Published: August 2017

To further evaluate the factors influencing public heat and air-quality health, a characterization of how urban areas affect the thermal environment, particularly in terms of the air temperature, is necessary. To assist public health agencies in ranking urban areas in terms of heat stress and developing mitigation plans or allocating various resources, this study characterized urban heat in California and quantified an urban heat island index (UHII) at the census-tract level (~1 km2). Multi-scale atmospheric modeling was carried out and a practical UHII definition was developed. The UHII was diagnosed with different metrics and its spatial patterns were characterized for small, large, urban-climate archipelago, inland, and coastal areas. It was found that within each region, wide ranges of urban heat and UHII exist. At the lower end of the scale (in smaller urban areas), the UHII reaches up to 20 degree-hours per day (DH/day; °C.hr/day), whereas at the higher end (in larger areas), it reaches up to 125 DH/day or greater. The average largest temperature difference (urban heat island) within each region ranges from 0.5–1.0 °C in smaller areas to up to 5 °C or more at the higher end, such as in urban-climate archipelagos. Furthermore, urban heat is exacerbated during warmer weather and that, in turn, can worsen the health impacts of heat events presently and in the future, for which it is expected that both the frequency and duration of heat waves will increase.
Changes in Seed Germination Ability, Lipid Peroxidation and Antioxidant Enzyme Activities of Ginkgo biloba Seed during Desiccation
Authors: Feng Jing , Shen Yongbao , Shi Fenghou , Li Chengzhong
Published: August 2017

With the aim of investigating the antioxidant system and germinability in response to the desiccation of Ginkgo biloba seeds, they were put in a drying room (25 ± 2% relative humidity, 25 °C) for 67 days. Results showed that the germination rate remained constant when seed moisture content (MC) decreased from 48% (fresh seeds) to 45.1%. However, when MC reached 40.1%, the germination percentage decreased from 92% to 50%. A significant positive correlation was observed between the MC and seed germination percentage (r = 0.910). The electrical conductivity was significantly increased during the initial desiccation (48–45.1%). Furthermore, both the superoxide dismutase (SOD) and peroxidase (POD) activity first reduced, then elevated to peak values before they declined again. POD activity rose earlier than SOD activity, indicating that the POD reaction was more desiccation-sensitive than the SOD. Significant negative correlations were observed between the MC and malondialdehyde (MDA) content (r = −0.619) and electrical conductivity (r = −0.745). Our collective results suggest that G. biloba seeds are highly sensitive to desiccation. Excessive desiccation could reduce the antioxidant enzyme activity of G. biloba seeds and intensify membrane lipid peroxidation, which causes the consequent reduction—or even the complete loss—of seed germinability.
A Survey of Denial-of-Service and Distributed Denial of Service Attacks and Defenses in Cloud Computing
Authors: Bonguet Adrien , Bellaiche Martine
Published: August 2017

Cloud Computing is a computing model that allows ubiquitous, convenient and on-demand access to a shared pool of highly configurable resources (e.g., networks, servers, storage, applications and services). Denial-of-Service (DoS) and Distributed Denial-of-Service (DDoS) attacks are serious threats to the Cloud services’ availability due to numerous new vulnerabilities introduced by the nature of the Cloud, such as multi-tenancy and resource sharing. In this paper, new types of DoS and DDoS attacks in Cloud Computing are explored, especially the XML-DoS and HTTP-DoS attacks, and some possible detection and mitigation techniques are examined. This survey also provides an overview of the existing defense solutions and investigates the experiments and metrics that are usually designed and used to evaluate their performance, which is helpful for the future research in the domain.
Comparison of Metabolic Syndrome Indicators in Two Samples of Central and South Americans Living in the Washington, D.C. Area in 1993–1994 and 2008–2009: Secular Changes in Metabolic Syndrome in Hispanics
Authors: Gill Regina , Jackson Robert , Duane Marguerite , Miner Allison , Khan Saira
Published: August 2017

The Central and South American populations are growing rapidly in the US; however, there is a paucity of information about their health status. Objectives: we estimated the prevalence of metabolic syndrome (MetS) and its individual components from two cohorts of Central and South Americans. Methods: This cross-sectional, medical record extraction survey sampled 1641 adults from a Washington, D.C clinic. A questionnaire was used to collect socio-demographic, medical history, anthropometric, biochemical, and clinical data. Results: among the 1993–1994 cohort, the MetS prevalence was 19.7%. The most prevalent MetS components were low high-density lipoprotein (HDL) cholesterol (40.4% men and 51.3% women), elevated triglycerides (40.9% men and 33.1% women), and high body mass index (BMI) ≥ 25 kg/m2 (27.6% men and 36.6% women). The overall prevalence of MetS in the 2008–2009 cohort was 28%. The most common abnormal metabolic indicator was an elevated BMI ≥ 25 kg/m2 (75.6%). 43.2% of men and 50.7% of women had HDL levels below normal, while the prevalence of hypertriglyceridemia was 46.5% and 32.5% for men and women, respectively. Conclusion: the prevalence of MetS was significantly greater in 2008–2009 compared with 1993–1994 (p ≤ 0.05). Dyslipidemia and high BMI have increased. Although similar components were identified in both the 1993–1994 and 2008–2009 study populations, the risks of MetS have increased over time.
A Diagnostic Post-Occupancy Evaluation of the Nacadia® Therapy Garden
Authors: Sidenius Ulrik , Karlsson Nyed Patrik , Linn Lygum Victoria , K. Stigsdotter Ulrika
Published: August 2017

The design of the Nacadia® therapy garden is based on a model for evidence-based health design in landscape architecture (EBHDL). One element of the model is a diagnostic post-occupancy evaluation (DPOE), which has not previously been fully developed. The present study develops a generic DPOE for therapy gardens, with a focus on studying the effects of the design on patients’ health outcomes. This is done in order to identify successes and failures in the design. By means of a triangulation approach, the DPOE employs a mixture of methods, and data is interpreted corroborating. The aim of the present study is to apply the DPOE to the Nacadia® therapy garden. The results of the DPOE suggest that the design of the Nacadia® therapy garden fulfills its stated aims and objectives. The overall environment of the Nacadia ® therapy garden was experienced as protective and safe, and successfully incorporated the various elements of the nature-based therapy programme. The participants encountered meaningful spaces and activities which suited their current physical and mental capabilities, and the health outcome measured by EQ-VAS (self-estimated general health) indicated a significant increase. Some design failures were identified, of which visual exposure was the most noteworthy. The DPOE model presented appears to be efficient but would nonetheless profit from being validated by other cases.
Respiratory Syncytial Virus: The Influence of Serotype and Genotype Variability on Clinical Course of Infection
Authors: Vandini Silvia , Biagi Carlotta , Lanari Marcello
Published: August 2017

Respiratory syncytial virus (RSV) belongs to the recently defined Pneumoviridae family, Orthopneumovirus genus. It is the leading cause of acute bronchiolitis and one of the most common causes of infant viral death worldwide, with infection typically occurring as recurrent seasonal epidemics. There are two major RSV subtypes, A and B, and multiple genotypes, which can coexist during RSV epidemic season every year and result in different disease severity. Recently, new RSV genomic sequences and analysis of RSV genotypes have provided important data for understanding RSV pathogenesis. Novel RSV strains do spread rapidly and widely, and a knowledge of viral strain-specific phenotypes may be important in order to include the more virulent strains in future therapeutical options and vaccine development. Here we summarize recent literature exploring genetic and molecular aspects related to RSV infection, their impact on the clinical course of the disease and their potential utility in the development of safe and effective preventive and therapeutic strategies.
Integrating Long Tide Gauge Records with Projection Modelling Outputs. A Case Study: New York
Authors: Watson Phil J.
Published: August 2017

Sea level rise is one of the key artefacts of a warming climate which is predicted to have profound impacts for coastal communities over the course of the 21st century and beyond. The IPCC provide regular updates (5–7 years) on the global status of the science and projections of climate change to assist guide policy, adaptation and mitigation endeavours. Increasingly sophisticated climate modelling tools are being used to underpin these processes with demand for improved resolution of modelling output products (such as predicted sea level rise) at a more localized scale. With a decade of common coverage between observational data and CMIP5 projection model outputs (2007–2016), this analysis provides an additional method by which to test the veracity of model outputs to replicate in-situ measurements using the case study site of New York. Results indicate that the mean relative velocity of the model projection products is of the order of 2.5–2.8 mm/year higher than the tide gauge results in 2016. In the event this phenomena is more spatially represented, there is a significant role for long tide gauge records to assist in evaluating climate model products to improve scientific rigour.
Finite Element Modeling of Multilayer Orthogonal Auxetic Composites under Low-Velocity Impact
Authors: Jiang Lili , Hu Hong
Published: August 2017

The multilayer orthogonal auxetic composites have been previously developed and tested to prove that they own excellent energy absorption and impact protection characteristics in a specific strain range under low-velocity impact. In this study, a three dimensional finite element (FE) model in ANSYS LS-DYNA was established to simulate the mechanical behavior of auxetic composites under low-velocity drop-weight impact. The simulation results including the Poisson’s ratio versus compressive strain curves and the contact stress versus compressive strain curves were compared with those in the experiments. The clear deformation pictures of the FE models have provided a simple and effective way for investigating the damage mechanism and optimizing the material, as well as structure design.
Incorporation of Collagen in Calcium Phosphate Cements for Controlling Osseointegration
Authors: Hu Ming-Hsien , Lee Pei-Yuan , Chen Wen-Cheng , Hu Jin-Jia
Published: August 2017

In this study, we investigated the effect of supplementing a non-dispersive dicalcium phosphate-rich calcium phosphate bone cement (DCP-rich CPC) with type I collagen on in vitro cellular activities and its performance as a bone graft material. Varying amounts of type I collagen were added during the preparation of the DCP-rich CPC. In vitro cell adhesion, morphology, viability, and alkaline phosphatase (ALP) activity were evaluated using progenitor bone cells. Bone graft performance was evaluated via a rat posterolateral lumbar fusion model and osteointegration of the implant. New bone formations in the restorative sites were assessed by micro-computed tomography (micro-CT) and histological analysis. We found that the incorporation of collagen into the DCP-rich CPC was associated with increased cell adhesion, cell viability, and ALP activity in vitro. The spinal fusion model revealed a significant increase in bone regeneration. Additionally, better osseointegration was observed between the host bone and graft with the DCP-rich CPC supplemented with collagen than with the collagen-free DCP-rich CPC control graft. Furthermore, compared to the control graft, the results of micro-CT showed that a smaller amount of residual material was observed with the collagen-containing DCP-rich CPC graft compared with the control graft, which suggests the collagen supplement enhanced new bone formation. Of the different mixtures evaluated in this study (0.8 g DCP-rich CPC supplemented with 0.1, 0.2, and 0.4 mL type I collagen, respectively), DCP-rich CPC supplemented with 0.4 mL collagen led to the highest level of osteogenesis. Our results suggest that the DCP-rich CPC supplemented with collagen has potential to be used as an effective bone graft material in spinal surgery.
Multiaxial Fatigue Damage Parameter and Life Prediction without Any Additional Material Constants
Authors: Yu Zheng-Yong , Zhu Shun-Peng , Liu Qiang , Liu Yunhan
Published: August 2017

Based on the critical plane approach, a simple and efficient multiaxial fatigue damage parameter with no additional material constants is proposed for life prediction under uniaxial/multiaxial proportional and/or non-proportional loadings for titanium alloy TC4 and nickel-based superalloy GH4169. Moreover, two modified Ince-Glinka fatigue damage parameters are put forward and evaluated under different load paths. Results show that the generalized strain amplitude model provides less accurate life predictions in the high cycle life regime and is better for life prediction in the low cycle life regime; however, the generalized strain energy model is relatively better for high cycle life prediction and is conservative for low cycle life prediction under multiaxial loadings. In addition, the Fatemi–Socie model is introduced for model comparison and its additional material parameter k is found to not be a constant and its usage is discussed. Finally, model comparison and prediction error analysis are used to illustrate the superiority of the proposed damage parameter in multiaxial fatigue life prediction of the two aviation alloys under various loadings.
X-ray Tomography Characterisation of Lattice Structures Processed by Selective Electron Beam Melting
Authors: Hernández-Nava Everth , Tammas-Williams Samuel , Smith Christopher , Leonard Fabien , Withers Philip , Todd Iain , Goodall Russell
Published: August 2017

Metallic lattice structures intentionally contain open porosity; however, they can also contain unwanted closed porosity within the structural members. The entrained porosity and defects within three different geometries of Ti-6Al-4V lattices, fabricated by Selective Electron Beam Melting (SEBM), is assessed from X-ray computed tomography (CT) scans. The results suggest that horizontal struts that are built upon loose powder show particularly high (~20 × 10−3 vol %) levels of pores, as do nodes at which many (in our case 24) struts meet. On the other hand, for struts more closely aligned (0° to 54°) to the build direction, the fraction of porosity appears to be much lower (~0.17 × 10−3%) arising mainly from pores contained within the original atomised powder particles.
Usual Choline Intakes Are Associated with Egg and Protein Food Consumption in the United States
Authors: Wallace Taylor , Fulgoni Victor
Published: August 2017

Choline is an essential nutrient with critical roles in several biological processes including neuronal development, cell signaling, nerve impulse transmission, and lipid transport and metabolism. The National Cancer Institute method was used to assess usual intakes of choline from foods according to data for participants enrolled in the National Health and Nutrition Examination Survey 2009–2014 datasets and pregnant women in the 2005–2014 datasets. Suboptimal intakes of choline are present across many gender and life-stage subpopulations, as well as pregnant women in the U.S. Only 8.03 ± 0.56% of adults and 8.51 ± 2.89% pregnant women meet the AI for choline. Children 2–3 years were the most likely to meet their gender and life-stage specific AI, followed by children 4–8 years. Adults 19+ years who consume eggs were more likely to meet their gender and life-stage AI as compared to non-consumers (57.3 ± 1.45% and 2.43 ± 0.28%). Consumers of eggs had almost double the usual intake of choline as compared to non-consumers (525 ± 5.17 mg/d and 294 ± 1.98; p < 0.0001). Protein food (meat, poultry and seafood) consumption also increased usual choline intakes compared to non-consumers (345 ± 2.21 mg/day and 235 ± 8.81; p < 0.0001) to a lesser degree, but did not result in substantial increases in the percent of individuals meeting the AI. No subpopulation exceeded the UL for choline. This research illustrates that it is extremely difficult to achieve the AI for choline without consuming eggs or taking a dietary supplement.
Diet Quality throughout Early Life in Relation to Allergic Sensitization and Atopic Diseases in Childhood
Authors: Nguyen Anh , Elbert Niels , Pasmans Suzanne , Kiefte-de Jong Jessica , De Jong Nicolette , Moll Henriëtte , Jaddoe Vincent , De Jongste Johan , Franco Oscar , Duijts Liesbeth , Voortman Trudy
Published: August 2017

Early-life nutrition is an important modifiable determinant in the development of a child’s immune system, and may thereby influence the risk of allergic sensitization and atopic diseases. However, associations between overall dietary patterns and atopic diseases in childhood remain unclear. We examined associations of diet quality in early life with allergic sensitization, self-reported physician-diagnosed inhalant and food allergies, eczema, and asthma among 5225 children participating in a population-based cohort in the Netherlands. Diet was assessed during pregnancy, infancy, and childhood using validated food-frequency questionnaires. We calculated food-based diet quality scores (0–10 or 0–15), reflecting adherence to dietary guidelines. At age 10 years, allergic sensitization was assessed with skin prick tests. Information on physician-diagnosed inhalant and food allergies, eczema, and asthma was obtained with questionnaires. We observed no associations between diet quality during pregnancy and allergic sensitization (odds ratio (OR) = 1.05 per point in the diet score, 95% confidence interval (CI): 0.99, 1.13), allergies (0.96, 95% CI: 0.88, 1.04), eczema (0.99, 95% CI: 0.93, 1.06), or asthma (0.93, 95% CI: 0.85, 1.03) in childhood. Also, diet quality in infancy or childhood were not associated with atopic outcomes in childhood. Our findings do not support our hypothesis that a healthy dietary pattern in early life is associated with a lower risk of allergic sensitization or atopic diseases in childhood.
“Omics” in Human Colostrum and Mature Milk: Looking to Old Data with New Eyes
Authors: Bardanzellu Flaminia , Fanos Vassilios , Reali Alessandra
Published: August 2017

Human Milk (HM) is the best source for newborn nutrition until at least six months; it exerts anti-inflammatory and anti-infective functions, promotes immune system formation and supports organ development. Breastfeeding could also protect from obesity, diabetes and cardiovascular disease. Furthermore, human colostrum (HC) presents a peculiar role in newborn support as a protective effect against allergic and chronic diseases, in addition to long-term metabolic benefits. In this review, we discuss the recent literature regarding “omics” technologies and growth factors (GF) in HC and the effects of pasteurization on its composition. Our aim was to provide new evidence in terms of transcriptomics, proteomics, metabolomics, and microbiomics, also in relation to maternal metabolic diseases and/or fetal anomalies and to underline the functions of GF. Since HC results are so precious, particularly for the vulnerable pre-terms category, we also discuss the importance of HM pasteurization to ensure donated HC even to neonates whose mothers are unable to provide. To the best of our knowledge, this is the first review analyzing in detail the molecular pattern, microbiota, bioactive factors, and dynamic profile of HC, finding clinical correlations of such mediators with their possible in vivo effects and with the consequent impact on neonatal outcomes.
Coordination-Driven Controlled Assembly of Polyphenol-Metal Green Coating on Wood Micro-Grooved Surfaces: A Novel Approach to Stable Superhydrophobicity
Authors: Wang Kaili , Wang Zhong , Dong Youming , Zhang Shifeng , Li Jianzhang
Published: August 2017

A versatile, fast, and nature-inspired polyphenol chemistry surface modification was applied to prepare superhydrophobic surfaces with micro-grooved structures in this study. Tannic acid and iron ion (TA–FeIII) complexes were employed as a molecular building block for anchoring biomimetic coating onto the wood substrate with catalytically reducing formative Ag ions as the rough surface to ensure well-developed micro/nanostructure hierarchical roughness. TA–FeIII complexes also acted as stable bridges between the substrate and hydrophobic groups. The thickness and architecture of TA–FeIII complex coatings can be tailored by coordination-driven multistep assembly. The results indicated that the micro/nano hierarchical roughness structure was well-developed with increased coating times and increased deposition of reduced Ag nanoparticles, resulting in excellent superhydrophobic properties (e.g., water CA (contact angle) of about 156° and a rolling angle of about 4°). The superhydrophobic material exhibited outstanding stability and durability in harsh conditions, including strong acid/base or organic solvent, high-temperature water boiling, ultrasonic cleaning, and ultraviolet aging. A series of superhydrophobic models are proposed to clarify the effect of the micro/nano hierarchical structure on these superhydrophobic properties.
Studies on Bhartṛhari and the Pratyabhijñā: The Case of svasaṃvedana
Authors: Ferrante Marco
Published: August 2017

The article addresses a critical problem in the history of South Asian philosophy, namely the nature of the ‘knowledge of knowledge’ (svasaṃvedana). In particular, it investigates how the Śaiva tantric school of the Pratyabhijñā (10th–11th c. CE) used the notion as an argument against the Buddhists’ ideas on the nature of the self. The paper then considers the possibility that the source of the Śaivas’ discussion was the work of the philosopher/grammarian Bhartṛhari (5th c. CE).
Automated Quantification of Surface Water Inundation in Wetlands Using Optical Satellite Imagery
Authors: DeVries Ben , Huang Chengquan , Lang Megan , Jones John , Huang Wenli , Creed Irena , Carroll Mark
Published: August 2017

We present a fully automated and scalable algorithm for quantifying surface water inundation in wetlands. Requiring no external training data, our algorithm estimates sub-pixel water fraction (SWF) over large areas and long time periods using Landsat data. We tested our SWF algorithm over three wetland sites across North America, including the Prairie Pothole Region, the Delmarva Peninsula and the Everglades, representing a gradient of inundation and vegetation conditions. We estimated SWF at 30-m resolution with accuracies ranging from a normalized root-mean-square-error of 0.11 to 0.19 when compared with various high-resolution ground and airborne datasets. SWF estimates were more sensitive to subtle inundated features compared to previously published surface water datasets, accurately depicting water bodies, large heterogeneously inundated surfaces, narrow water courses and canopy-covered water features. Despite this enhanced sensitivity, several sources of errors affected SWF estimates, including emergent or floating vegetation and forest canopies, shadows from topographic features, urban structures and unmasked clouds. The automated algorithm described in this article allows for the production of high temporal resolution wetland inundation data products to support a broad range of applications.
Novel Decomposition Scheme for Characterizing Urban Air Quality with MODIS
Authors: Misra Prakhar , Fujikawa Aya , Takeuchi Wataru
Published: August 2017

Urban air pollution is one of the most widespread global sustainability problems. Previous research has studied growth or fall of particulate matter (PM) levels using on-ground monitoring stations in urban regions. However, studying this worldwide is difficult because most cities do not have sufficient infrastructure to monitor air quality. Thus, satellite data is increasingly being employed to solve this limitation. In this paper, we use 16 years (2001–2016) of aerosol optical depth (AOD) and Angstrom exponent ( α ) datasets, retrieved from MODIS (Moderate Resolution Imaging Spectroradiometer) sensors on the National Aeronautics and Space Administration’s (NASA) Terra satellite to study air quality over 60 locations globally. We propose a novel technique, called AirRGB decomposition, to characterize urban air quality by decomposing AOD and α retrievals into ‘components’ of three distinct scenarios. In the AirRGB decomposition method, using AOD and α dataset three scenarios were investigated: ‘R’—high α and high AOD, ‘G’—high α and low AOD, and ‘B’—low α and low AOD values. These scenarios were mapped and quantified over a triangular red, green and blue color scale. This visualization easily segregates regions having a high concentration of industrial aerosol from only natural aerosols. Our analysis indicates that a sharp divide exists between North American and European cities and Asian cities in terms of baseline pollution and slopes of R and G trends. We found that while pollution in cities in China has started to decrease (e.g., since 2011 for Beijing), it continues to increase in South Asia and Southeast Asia. e.g., R offset of Beijing and New Delhi was 54.98 and 50.43 respectively but R slope was −0.04 and 0.08 respectively. High offset (≥45) and slope (≥0.025) of B for New York, Tokyo, Sydney and Sao Paolo shows that they have clean air, which is still getting better.
A Modified Dual-Baseline PolInSAR Method for Forest Height Estimation
Authors: Xie Qinghua , Zhu Jianjun , Wang Changcheng , Fu Haiqiang , Lopez-Sanchez Juan M. , Ballester-Berman J. David
Published: August 2017

This paper investigates the potentials and limitations of a simple dual-baseline PolInSAR (DBPI) method for forest height inversion. This DBPI method follows the classical three-stage inversion method’s idea used in single baseline PolInSAR (SBPI) inversion, but it avoids the assumption of the smallest ground-to-volume amplitude ratio (GVR) by employing an additional baseline to constrain the inversion procedure. In this paper, we present for the first time an assessment of such a method on real PolInSAR data over boreal forest. Additionally, we propose an improvement on the original DBPI method by incorporating the sloped random volume over ground (S-RVoG) model in order to reduce the range terrain slope effect. Therefore, a digital elevation model (DEM) is needed to provide the slope information in the proposed method. Three scenes of P-band airborne PolInSAR data acquired by E-SAR and light detection and ranging (LIDAR) data available in the BioSAR2008 campaign are employed for testing purposes. The performance of the SBPI, DBPI, and modified DBPI methods is compared. The results show that the DBPI method extracts forest heights with an average root mean square error (RMSE) of 4.72 m against LIDAR heights for trees of 18 m height on average. It presents a significant improvement of forest height accuracy over the SBPI method (with a stand-level mean improvement of 42.86%). Concerning the modified DBPI method, it consistently improves the accuracy of forest height inversion over sloped areas. This improvement reaches a stand-level mean of 21.72% improvement (with a mean RMSE of 4.63 m) for slopes greater than 10°.
Progressive Line Processing of Kernel RX Anomaly Detection Algorithm for Hyperspectral Imagery
Authors: Zhao Chunhui , Deng Weiwei , Yan Yiming , Yao Xifeng
Published: August 2017

The Kernel-RX detector (KRXD) has attracted widespread interest in hyperspectral image processing with the utilization of nonlinear information. However, the kernelization of hyperspectral data leads to poor execution efficiency in KRXD. This paper presents an approach to the progressive line processing of KRXD (PLP-KRXD) that can perform KRXD line by line (the main data acquisition pattern). Parallel causal sliding windows are defined to ensure the causality of PLP-KRXD. Then, with the employment of the Woodbury matrix identity and the matrix inversion lemma, PLP-KRXD has the capacity to recursively update the kernel matrices, thereby avoiding a great many repetitive calculations of complex matrices, and greatly reducing the algorithm’s complexity. To substantiate the usefulness and effectiveness of PLP-KRXD, three groups of hyperspectral datasets are used to conduct experiments.
Relevance of Reactive Fe:S Ratios for Sulfur Impacts on Arsenic Uptake by Rice
Authors: Boye Kristin , Lezama-Pacheco Juan , Fendorf Scott
Published: August 2017

Human arsenic exposure from rice consumption is a global concern. Due to the vast areas of naturally contaminated soils in rice-producing regions, the only possibility for reducing hazardous exposure is to prevent As uptake and translocation to rice grain. Sulfur inhibits As mobility both in soil and plant, indicating that soil S content may be a primary factor controlling As uptake; indeed, gypsum (CaSO4·H2O) has been proposed as a potential amendment. Here, we investigated S controls on rice As uptake within two naturally contaminated soils (15.4 and 11.0 mg As per kg soil, respectively) from Cambodia, by adding gypsum at two levels (20 and 60 mg per kg soil). We found that although gypsum initially decreased As release to soil solution, the concentrations then increased compared to the control treatment. Further, As concentrations in rice biomass were generally insignificantly affected by the gypsum treatments and trended in opposite directions between the two soils. Single and multivariate statistical tests indicated that Fe exerted stronger control on As uptake in rice than S and that the initial ratio of reactive Fe to sulfate-S had an overriding impact on As uptake in rice. However, in the soil with higher inherent sulfate content (91 mg SO42−-S per kg soil) the additional S provided by gypsum appeared to increase the ability of the rice plant to prevent As translocation to grain. We conclude that S may contribute to regulating grain As concentrations, but that the effect is highly dependent on S:Fe(As) ratios. Thus, at modest amendment rates, gypsum has limited potential for minimizing As concentration in rice when applied to naturally contaminated soil, particularly if the reactive Fe(III) content is high.
Balancing Rural Household Livelihood and Regional Ecological Footprint in Water Source Areas of the South-to-North Water Diversion Project
Authors: Wang Chen , Shi Guoqing , Wei Yongping , Western Andrew , Zheng Hang , Zhao Yan
Published: August 2017

There is a knowledge gap and practical demand to understand the co-evolutionary relationship between rural household livelihood and regional ecological footprints for developing sustainable livelihoods in ecological conservation regions. This paper tracks the change trajectories of rural household livelihoods and regional ecological footprints in four water source areas of the South-to-North Water Diversion Project where various ecological and environmental protection projects and measures are being proposed to protect water quality. As a result, some concerns regarding rural livelihood have arisen. The sustainable livelihood approach developed by DFID (Department for International Development in UK) was used to measure the natural, physical, financial, human, and social capitals of rural livelihoods, while the ecological footprint accounting approach was used to calculate the amount of bio-productive spaces that produce the yearly resource flows for human consumption. The study period is 2000–2014 and data was obtained from the Statistical Yearbooks. The results show that the change trend of natural capitals of rural households, which have increased by 72.5% (SY), 98.8% (NY), 69.3% (TA), and 120.3% (JN) within 15 years, determine the overall change track of rural livelihoods and that rural household livelihood grows with the expansion of regional ecological footprints. Sensitivity of regional eco-footprints to rural livelihood varies from 5.8 to 0.5 in case areas. It is recommended that in the “post South-to-North Water Diversion era”, four policy instruments—population transfer and relocation, industrial restructuring and updating, rural infrastructure and community reconstruction, and cross-ecological compensation—should be adopted to improve sustainable livelihoods in these four water source areas.
Interaction between Various Apple Procyanidin and Staphylococcal Enterotoxin A and Their Inhibitory Effects on Toxin Activity
Authors: Shimamura Yuko , Hirai Chikako , Sugiyama Yuka , Utsumi Mio , Yanagida Akio , Murata Masatsune , Ohashi Norio , Masuda Shuichi
Published: August 2017

In this study, we investigated the interaction between apple polyphenols (AP; mainly consisting of procyanidin (PC) from an apple) and staphylococcal enterotoxin A (SEA), and the inhibitory effects of AP on SEA activity. According to the degree of polymerization, in particularly highly polymerized PC (more than pentamer) strongly interacted with SEA. The binding affinity of AP with SEA molecules was determined using Biacore analysis. AP reacted with SEA immobilized on a Biacore sensor chip. After treatment with pepsin and pancreatin, to examine the changes of binding affinity of AP in intragastric conditions, AP maintained interaction with SEA. We examined whether AP inhibits the proliferation and interferon-γ (IFN-γ) production induced by SEA in mouse spleen cells. AP strongly inactivated the proliferation and IFN-γ production induced by SEA. These results suggest that AP, which has a higher degree of polymerization, inactivates stronger biological activity of SEA through interaction with SEA. Our studies are the first to demonstrate the relationship between the degree of polymerization of AP and the inhibitory effects on SEA activities.
Multi–Model Ensemble Approaches to Assessment of Effects of Local Climate Change on Water Resources of the Hotan River Basin in Xinjiang, China
Authors: Luo Min , Meng Fanhao , Liu Tie , Duan Yongchao , Frankl Amaury , Kurban Alishir , De Maeyer Philippe
Published: August 2017

The effects of global climate change threaten the availability of water resources worldwide and modify their tempo-spatial pattern. Properly quantifying the possible effects of climate change on water resources under different hydrological models is a great challenge in ungauged alpine regions. By using remote sensing data to support established models, this study aimed to reveal the effects of climate change using two models of hydrological processes including total water resources, peak flows, evapotranspiration, snowmelt and snow accumulation in the ungauged Hotan River Basin under future representative concentration pathway (RCP) scenarios. The results revealed that stream flow was much more sensitive to temperature variation than precipitation change and increased by 0.9–10.0% according to MIKE SHE or 6.5–10.5% according to SWAT. Increased evapotranspiration was similar for both models with a range of 7.6–31.3%. The snow-covered area shrank from 32.5% to 11.9% between the elevations of 4200–6400 m, respectively, and snow accumulation increased when the elevation exceeded 6400 m above sea level (asl). The results also suggested that the fully distributed and semi-distributed structures of these two models strongly influenced the responses to climate change. The study proposes a practical approach to assess the climate change effect in ungauged regions.
Non-Dominated Sorting Harmony Search Differential Evolution (NS-HS-DE): A Hybrid Algorithm for Multi-Objective Design of Water Distribution Networks
Authors: Yazdi Jafar , Choi Young Hwan , Kim Joong Hoon
Published: August 2017

We developed a hybrid algorithm for multi-objective design of water distribution networks (WDNs) in the present study. The proposed algorithm combines the global search schemes of differential evolution (DE) with the local search capabilities of harmony search (HS) to enhance the search proficiency of evolutionary algorithms. This method was compared with other multi-objective evolutionary algorithms (MOEAs) including NSGA2, SPEA2, MOEA/D and extended versions of DE and HS combined with non-dominance criteria using several metrics. We tested the compared algorithms on four benchmark WDN design problems with two objective functions, (i) the minimization of cost and (ii) the maximization of resiliency as reliability measure. The results showed that the proposed hybrid method provided better optimal solutions and outperformed the other algorithms. It also exhibited significant improvement over previous MOEAs. The hybrid algorithm generated new optimal solutions for a case study that dominated the best-known Pareto-optimal solutions in the literature
Adrenal Myelolipoma Diagnosed in a 72-Year-Old Patient with Abdominal Pain
Authors: Franca Tiago Galan de , Rocha Gabriela Ferreira , Calixto Sheyla Cristina De Souza
Published: August 2017

BACKGROUND: Adrenal myelolipoma is a rare benign tumor formed by hematopoietic tissue and mature adipose tissue. Usually is insidious and found occasionally on image exams, therefore is also called incidentaloma. Image studies and anatomopathological exam are important to define the diagnosis of adrenal myelolipoma. This study’s objective was to report the case of this rare adrenal tumor and its main diagnostic means.

CASE: It was report case about a 72-year-old patient, whose initial symptom was diffuse abdominal pain, nausea and vomiting, diagnosed with adrenal myelolipoma after image studies even in the absence of laboratory abnormalities, and submitted at a private hospital at Belém-PA.

CONCLUSIONS: The adrenal myelolipoma, due its usual asymptomatic characteristics or its no-specifics symptoms, requires a meticulous analysis concerning both diagnosis and treatment. Thus, our case report corroborates the importance of the image studies in front of an obscure and difficult diagnosis, especially the computed tomography, and anatomopathological evaluation, since they are essential to the best decision making and consequently a better prognosis of the patient.
Preliminary Evidence for a Virial Shock around the Coma Galaxy Cluster
Authors: Keshet Uri , Kushnir Doron , Loeb Abraham , Waxman Eli
Published: August 2017

Galaxy clusters, the largest gravitationally bound objects in the universe, are thought to grow by accreting mass from their surroundings through large-scale virial shocks. Due to electron acceleration in such a shock, it should appear as a γ-ray, hard X-ray, and radio ring, elongated toward the large-scale filaments feeding the cluster, coincident with a cutoff in the thermal Sunyaev–Zel’dovich (SZ) signal. However, no such signature was found until now, and the very existence of cluster virial shocks has remained a theory. We find preliminary evidence for a large γ-ray ring of

minor axis around the Coma cluster, elongated toward the large-scale filament connecting Coma and Abell 1367, detected at the nominal

confidence level (

using control signal simulations). The γ-ray ring correlates both with a synchrotron signal and with the SZ cutoff, but not with Galactic tracers. The γ-ray and radio signatures agree with analytic and numerical predictions if the shock deposits

of the thermal energy in relativistic electrons over a Hubble time and

in magnetic fields. The implied inverse Compton and synchrotron cumulative emission from similar shocks can contribute significantly to the diffuse extragalactic γ-ray and low-frequency radio backgrounds. Our results, if confirmed, reveal the prolate structure of the hot gas in Coma, the feeding pattern of the cluster, and properties of the surrounding large-scale voids and filaments. The anticipated detection of such shocks around other clusters would provide a powerful new cosmological probe.
Fast Magnetic Reconnection: “Ideal” Tearing and the Hall Effect
Authors: Pucci Fulvia , Velli Marco , Tenerani Anna
Published: August 2017

One of the main questions in magnetic reconnection is the origin of triggering behavior with on/off properties that, once it is activated, accounts for the fast magnetic energy conversion to kinetic and thermal energies at the heart of explosive events in astrophysical and laboratory plasmas. Over the past decade, progress has been made on the initiation of fast reconnection via the plasmoid instability and what has been called “ideal” tearing, which sets in once current sheets thin to a critical inverse aspect ratio

. As shown by Pucci & Velli, at

, the timescale for the instability to develop becomes of the order of the Alfvén time and independent of the Lundquist number (here defined in terms of current sheet length L). However, given the large values of S in natural plasmas, this transition might occur for thicknesses of the inner resistive singular layer that are comparable to the ion inertial length d

i
. When this occurs, Hall currents produce a three-dimensional quadrupole structure of the magnetic field, and the dispersive waves introduced by the Hall effect accelerate the instability. Here we present a linear study showing how the “ideal” tearing mode critical aspect ratio is modified when Hall effects are taken into account, including more general scaling laws of the growth rates in terms of sheet inverse aspect ratio: the critical inverse aspect ratio is amended to

, at which point the instability growth rate becomes Alfvénic and does not depend on either of the (small) parameters

. We discuss the implications of this generalized triggering aspect ratio for recently developed phase diagrams of magnetic reconnection.