bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality Assessment of Marinated Halva Sya (Parastromateus niger) Fillets
During Storage at 4 °C
Authors: Aberouamd Ali , Asvad Fatemeh
Published: May 2022

Background:

In recent years, there has been an increasing interest in using natural
food additives to improve the shelf life of marinated food.

Aim:

This research aimed to examine physicochemical changes promoted by a marinating process
in Halva Sya fish fillets during cold storage.

Methods:

Fish fillets were immersed in 500 ccs of lemon juice, 200 g of grated garlic, 60 g of
salt, 3 g of turmeric, 1 g of red pepper powder, 3 g of black pepper powder with 100 cc of distilled
water for preparation of traditional marinades and stored at -4 °C for 25 days. Some physicochemical
characteristics like pH and proximate composition were performed at 7, 18 and 25-
day intervals.

Results:

Results showed that although the values of proximate composition, energy values and
pH in marinated samples were different than control ones, the differences were insignificant
(p>0.05).

Conclusion:

The marinade sample in treatment 1 was found to be most acceptable, followed by
Marinade in treatment 3. The shelf-life of the marinated Halva Sya fish based on physicochemical
analyses at refrigerated storage (4 °C) was 7 days.
Pattern Classification for Ovarian Tumors by Integration of Radiomics
and Deep Learning Features
Authors: Liao Shengwu , Lu Zhentai , Liu Pengfei , Liang Xiaokang
Published: May 2022

Background:

Ovarian tumor is a common female genital tumor, among which malignant
tumors have a poor prognosis. The survival rate of 70% of patients with ovarian cancer is less than 5
years, while benign ovarian tumor is better, so the early diagnosis of ovarian cancer is important for
the treatment and prognosis of patients.

Objectives:

Our aim is to establish a classification model for ovarian tumors.

Methods:

We extracted radiomics and deep learning features from patients’CT images. The four-step
feature selection algorithm proposed in this paper was used to obtain the optimal combination of features,
then, a classification model was developed by combining those selected features and support
vector machine. The receiver operating characteristic curve and an area under the curve (AUC) analysis
were used to evaluate the performance of the classification model in both the training and test cohort.

Results:

The classification model, which combined radiomics features with deep learning features,
demonstrated better classification performance with respect to the radiomics features model alone in
training cohort (AUC 0.9289 vs. 0.8804, P < 0.0001, accuracy 0.8970 vs. 0.7993, P < 0.0001), and
significantly improve the performance in the test cohort (AUC 0.9089 vs. 0.8446, P = 0.001, accuracy
0.8296 vs. 0.7259, P < 0.0001).

Conclusion:

The experiments showed that deep learning features play an active role in the construction
of classification model, and the proposed classification model achieved excellent classification performance,
which can potentially become a new auxiliary diagnostic tool.
Heavy and Chronic Cannabis Addiction does not Impact Motor Function: A BOLD-fMRI Study
Authors: Boujraf Saïd , Alami Badreeddine , Chikri Mohamed , El Hamdaoui Halima , Maaroufi Mustapha , Aalouane Rachid , Rammouz Ismail
Published: May 2022

Objective:

The goal of this to demonstrate the impact of heavy and chronic cannabis use on
brain potential functional control, reorganization, and plasticity in the cortical area.

Methods:

23 cannabis users were convened in 3 groups of users. The first group included 11 volunteers
with an average of 15 joins/day; the second group included 6 volunteers with an average of 1.5
joins/day; the third group included 6 volunteers with an average of 2.8 joins/week. Besides, 6 healthy
volunteers in the control group, All healthy and cannabis users underwent identical brain BOLD-fMRI
assessments of their motor function. Besides, neuropsychological and full biological assessments were
achieved.

Results:

BOLD-fMRI maps of motor areas were obtained, including quantitative evaluation of the
activations in the motor area. A statistical analysis of various groups was achieved.

Conclusion:

Groups of chronic cannabis addiction of varying level of use were setup. Namely heavy,
moderate and low users groups; doses have been shown to have systematically equivalent effects on
the control of brain motor function. Indeed, the BOLD-fMRI shows a remarkable sensitivity to brain
plasticity and reorganization of the functional motor control of the studied cortical area, and such variation
was not shown. Specific elucidation of the effect of cannabis effect in this unique function
should clarify further protective pharmacological effects. This might illuminate the use of neuronal
resources to prepare processes for pharmacological use and pharmaceutical forms. This suggests
exploring any potential cannabis pharmaceutical form in diseases involving motor impairments.
An Insight through Various Models being used for Assessment of Depression
and its Management at Primary Level in Current Scenario
Authors: Bee Rizwana , Ahmad Mohammad , Verma Shashi
Published: May 2022

Aim:

The main aim of present study to assess depression and various neurotransmitters
involved in it with their evaluating models.

Background:

Depression is a common ailment that can be recurrent or even become chronic. According
to the National Service Framework for Mental Health (released in 1999 by the Department
of Health), people with depression should continue to be treated primarily in primary care settings.
Despite mounting evidence that general practitioners could do a better job of detecting and treating
depression, little research has been done on the perspectives of general practitioners who treat patients
who are depressed. Depression (major depressive disorder) is a widespread and significant medical
condition that has a negative impact on feeling, thinking, and behaviour.

Objectives:

The primary goal of this study was to gather data on depression, as well as to discuss several
methods for evaluating antidepressant drug response based on physical activities and neurotransmitters.

Method:

Antidepressant activity of various medications can be tested using two different types of
studies, including in-vivo and in-vitro, according to the review.

Result:

Depression is characterized by a persistent sense of sadness, insomnia, lack of concentration,
slowness in activity, restlessness, social isolation and a loss of interest that prevents you from doing
normal things. There are several types of depression, with symptoms ranging from mild to severe. Depression
is caused by a combination of factors and conditions, rather than a single factor. Major depression
is a mental condition marked by feelings of inadequacy, hopelessness, decreased activity,
sadness and mood swings, which seriously disrupt and negatively affect a person's life, sometimes,
leading to suicidal thoughts. The quest for a better understanding of the causes of depression and the
development of more effective treatments is critical. According to clinical and preclinical research,
stress appears to be a crucial mediator in the pathophysiology of depression. Using experimental models,
depression may be assessed based on several physical parameters such as locomotor activity, rearing,
defecation, and the number of centre square entries (in vivo and in vitro). Biological parameters
may also be used to locate it.

Conclusion:

Unhappiness and loss of interest in previously enjoyed activities are the symptoms of depression.
It can cause emotional and physical problems, as well as a decrease in the ability to function
together at work and at home. Finally it has been concluded that various neurotransmitters are involved
in depression at the synaptic cleft which can be controlled using various synthetic and herbal
drugs through in vitro and in vivo evaluating models.
Antidiabetic Drugs and their Potential Use in COVID-19: A Mechanistic
Approach
Authors: Balderas-Renteria Isaias , Espinosa-Rodriguez Bryan Alejandro , Nieto-Moreno Aissa Michelle , Gonzalez Llerena Jose Luis , Rico-Torres Tania Alejandra , Carranza-Rosales Pilar , Mendez-Lopez Luis Fernando
Published: May 2022

Many therapies have been developed against COVID-19 since it first appeared in December 2019. Antivirals, antimalarials, cephalosporins, colchicine, anticoagulants, and corticosteroids, among others, have been evaluated as protecting agents against antibacterial complications
due to their anti-inflammatory and immunomodulatory effects against thrombosis and cell death
caused by infection with SARS-CoV-2. Nevertheless, the overall balance in their application has
not been found to be satisfactory. On the other hand, developing and applying several vaccines
against this virus have marked an important watershed in preventive and prophylactic medicine in
the new millennium. However, given the regular efficacy reported of some of them, the still scarce
affordability, and the emergency of new strains for which no drug has been evaluated, the search
for new pharmacological therapy alternatives still represents an essential component in the clinical
management of COVID-19, and the rapid identification of drugs with potential antiviral and/or
immunomodulatory properties is needed. In the present review, a potential therapeutic effect of
metformin and other antidiabetic therapies for the management of COVID-19 are proposed and
discussed from the viewpoint of their in vitro and in vivo immunomodulatory effects. Given that
acute inflammation is an important component of COVID-19, antidiabetic therapies could be promising alternatives in its management and reducing the disease's severity. In order to understand how
metformin and other antidiabetic therapies could work in the context of COVID-19, here we review
the possible mechanisms of action through a detailed description of cellular and molecular events.
Is Testosterone the “Fountain of Youth” for Aging Men?
Authors: Giagulli Vito Angelo , Lisco Giuseppe , Mariano Francesco , De Tullio Anna , Triggiani Vincenzo
Published: May 2022

Background:

Late-Onset Hypogonadism (LOH) is defined as a clinical and biochemical
syndrome associated with advancing age. It is characterized by specific symptoms and less
specific manifestations due to deficiency of serum testosterone (T) levels.

Objective:

This review aims to summarize the evidence related to LOH definition, diagnostic
approach, and treatment to answer a clinical question: “Is Testosterone the fountain of youth for
aging men?".

Methodology:

MEDLINE/PubMed and institutional websites were searched for original papers,
guidelines, and position statements published in the last ten years.

Results:

Observational and randomized controlled studies on T replacement therapy in older men
have been reported.

Discussion and Conclusion:

Despite some heterogeneities regarding diagnostic definition, therapeutic
target, and testosterone prescription, all guidelines agreed that male hypogonadism should
be diagnosed and managed in aged men as in adulthood. However, trials assessing the efficacy
of T therapy conducted for male rejuvenating are lacking; thus, T prescription for this purpose is
not recommended.
A New Device for Remote Monitoring of Vital Parameters in Acromegalic
Patients: Pilot Study
Authors: Costa Denise , D’Amico Tania , Mercuri Valeria , Schiaffini Riccardo , Gargiulo Patrizia
Published: May 2022

Introduction:

Acromegaly is a rare disease that results from growth hormone (GH)
excess. Diabetes mellitus, hypertension,cardiomyopathy, and obstructive sleep apnoea syndrome(
OSAS) are frequent complications.

Aim of the study:

Identify a useful system to obtain a reliable remote monitoring of glucose and
the most important vital parameters in the acromegalic subjects.

Patients and Methods:

Sixteen acromegalic patients (from 30 to 73 years old) were enrolled. We
provided health monitor devices to the patients for continuous acquisition of physiological signals
including twelve-lead electrocardiography (EKG) and nocturnal SpO2. At the same time, we applied
on the same patients the blinded continuous glucose monitoring system(CGMS).

Results:

The lowest saturation peaks at night (<80%) were achieved in patients with a known
diagnosis of OSAS. A positive correlation was demonstrated between the lowest oxygen saturation
values and the CGM peaks (pV <0,0001) and between the average values of oxygen saturation
and CGM (pV<0,0003). Patients with a previous diagnosis of OSAS, obtained by polysomnography,
showed on the multiparametric monitor recordings superimposable to their known
condition. Instead we noticed a discordance in the two EKG recording: the wireless mode showed
an irregular rhythm in 5/16 patients, which was not confirmed by the recording mode with cables.

Conclusion:

The health monitor device associated with CGM may be a new useful and versatile
tool for fragile patients who can self-manage remote monitoring, and for physicians who can
obtain real-time information for the clinical and therapeutic management of patients. It is also a
useful tool for the follow-up of patients with OSAS. Moreover, once the interference of the OSAS
is excluded, the CGM allows us to obtain a more reliable and accurate diagnosis of DM.
A Chronic Inflammatory Inductive Condition in the Nursing Profession: A
Scoping Review
Authors: Vitale Elsa
Published: May 2022

Background:

Literature focuses on the well-being of patients and little on the well-being of nurses who, in turn, should be educated about well-being. The latter, on the other hand, very often have to work under serious pressure with inadequate resources and shift organization exposing them to health risk factors.

Objective:

To highlight which relationships exist between: diet, physical activity, body mass index (BMI) and mental health in the nursing profession.

Methods:

Author searched Medline (PubMed) database for medical subheadings terms and free full text referred to “Diet”, “Mental Health”, “Physical Activity”, “Nurses”, before 31st December 2020.

Results:

A total of 11 studies were included in this perspective review which better defined the relationships existing between diet, physical activity, mental health and nursing profession.

Conclusion:

From the studies present in literature it emerges that the nursing profession has an inherent imbalance in the regular circadian activity of human nature, as nursing assistance is provided 24 hours a day, therefore also during the night. Numerous studies have already highlighted significant differences between levels of mental and eating disorders among nurses who also work at night versus those who only work during the day. Therefore, it is possible to speak of the nursing profession as an “inductive inflammatory-chronic” activity on the basis of the extensive scientific evidence provided by literature.
Impact of a Papillomavirus Vaccination Promotion Program in Middle School: Study Protocol for a Cluster Controlled Trial
Authors: Tran Phuong Lien , Chirpaz Emmanuel , Boukerrou Malik , Bertolotti Antoine
Published: May 2022

Background

On Reunion Island, incidence and mortality for uterine cervical cancer is high, yet coverage rate for human papillomavirus (HPV) vaccination is low.

Objective

The main objective of the study is to evaluate the impact of a health promotion program promoting HPV vaccination on the proportion of middle school girls who complete the full HPV vaccination schedule (2 or 3 doses) by the end of school year.

Methods

This study is a cluster controlled intervention study using a superiority design. A combined health promotion program will be offered containing information to students and parents, training of general practitioners, and free school-based vaccination (in a “health bus”). Children who attend this program will constitute the intervention group and will be compared to children from another middle school who will not attend the program constituting the control group.

Results

Recruitment began in October 2020. In the intervention school, of 780 students, 245 were randomly selected in the 12 classes. In the control school, 259 students out of 834 were randomly selected.

Conclusions

In this study, we explore the impact of a health promotion program combining information toward students, parents, and general practitioners with free school-based vaccination. We expect a significantly higher HPV vaccination coverage in the intervention school as compared to the control school, whether it be among girls or boys. The final implication would be an extension of this program in all middle schools on the Island and thus an increase in HPV vaccination coverage.

Trial Registration

ClinicalTrials.gov NCT04459221; https://clinicaltrials.gov/ct2/show/NCT04459221

International Registered Report Identifier (IRRID)

DERR1-10.2196/35695
The First National Remote Emergency System for Malignant Hyperthermia (MH-NRES) in China: Protocol for the Design, Development, and Evaluation of a WeChat Applet
Authors: Yu Hong , Tan Lingcan , Teng Yi , Xu Zhao , Xiao Kun , Yin Jin , Zuo Yunxia , Zhu Tao , Deng Xiaoqian
Published: May 2022

Background

Malignant hyperthermia (MH) is a rare life-threatening anesthetic emergency. With respect to the high fatality rate, difficulty in early recognition, and the lack of disease-specific drug (ie, dantrolene) in China, more effort is needed to strengthen early diagnosis and effective treatment of MH emergencies. Nowadays, mobile health (mHealth) apps are changing the way of medical practice; they can serve as an accessible tool to help anesthesiologists deal with MH crises. However, no related mHealth-based emergency system is available currently.

Objective

The aim of this study is to outline the protocol for the development of a WeChat applet used to design a National Remote Emergency System for Malignant Hyperthermia (MH-NRES) in China, as well as the protocol for the evaluation of the user experience and perception of the system.

Methods

The system adopts the client-server architecture, with a custom user interface operating as clients and the back-end system operating as the server. The client-side software was developed using uni-app technology with Vue.js-based framework, which consists of 6 modules: Quick Diagnosis, Dantrolene Mobilization, Instruction on Dantrolene Use, MH Treatment, Recovery Period Treatment, and DNA Test and Biopsy. The back-end system was developed based on the Spring framework. The system will be evaluated by administrating a modified user version of the Mobile App Rating Scale. Pilot testing will be conducted in Sichuan Province, China, and a subsequent evaluation on a national scale is planned.

Results

The theoretical framework design of this system was completed in August 2021. The development of the system was completed in February 2022, and the refinement is currently ongoing. Pilot testing after the implementation of the system in Sichuan Province is planned to take 2 months, and the subsequent evaluation on a national scale is planned to take 2 months.

Conclusions

We have described a novel approach using the WeChat applet to develop the MH-NRES. Findings from the usability testing process in the current study may lead to refinements and is expected to suggest that this system is both feasible and welcomed by anesthesiologists. Depending on the availability of research funding, this system will be extended nationally across China.

International Registered Report Identifier (IRRID)

PRR1-10.2196/37084
Exploring the Risk of Suicide in Real Time on Spanish Twitter: Observational Study (Preprint)
Authors: García-Martínez Claudia , Oliván-Blázquez Bárbara , Fabra Javier , Martínez-Martínez Ana Belén , Pérez-Yus María Cruz , López-Del-Hoyo Yolanda
Published: May 2022

BACKGROUND

Social media is now a common context wherein people express their feelings in real time. These platforms are increasingly showing their potential to detect the mental health status of the population. Suicide prevention is a global health priority and efforts toward early detection are starting to develop, although there is a need for more robust research.

OBJECTIVE

We aimed to explore the emotional content of Twitter posts in Spanish and their relationships with severity of the risk of suicide at the time of writing the tweet.

METHODS

Tweets containing a specific lexicon relating to suicide were filtered through Twitter's public application programming interface. Expert psychologists were trained to independently evaluate these tweets. Each tweet was evaluated by 3 experts. Tweets were filtered by experts according to their relevance to the risk of suicide. In the tweets, the experts evaluated: (1) the severity of the general risk of suicide and the risk of suicide at the time of writing the tweet (2) the emotional valence and intensity of 5 basic emotions; (3) relevant personality traits; and (4) other relevant risk variables such as helplessness, desire to escape, perceived social support, and intensity of suicidal ideation. Correlation and multivariate analyses were performed.

RESULTS

Of 2509 tweets, 8.61% (n=216) were considered to indicate suicidality by most experts. Severity of the risk of suicide at the time was correlated with sadness (ρ=0.266; P<.001), joy (ρ=–0.234; P=.001), general risk (ρ=0.908; P<.001), and intensity of suicidal ideation (ρ=0.766; P<.001). The severity of risk at the time of the tweet was significantly higher in people who expressed feelings of defeat and rejection (P=.003), a desire to escape (P<.001), a lack of social support (P=.03), helplessness (P=.001), and daily recurrent thoughts (P=.007). In the multivariate analysis, the intensity of suicide ideation was a predictor for the severity of suicidal risk at the time (β=0.311; P=.001), as well as being a predictor for fear (β=–0.009; P=.01) and emotional valence (β=0.007; P=.009). The model explained 75% of the variance.

CONCLUSIONS

These findings suggest that it is possible to identify emotional content and other risk factors in suicidal tweets with a Spanish sample. Emotional analysis and, in particular, the detection of emotional variations may be key for real-time suicide prevention through social media.
Using Mixed Reality Headsets to Deliver Remote Bedside Teaching During the COVID-19 Pandemic: Feasibility Trial of HoloLens 2 (Preprint)
Authors: Sivananthan Arun , Gueroult Aurelien , Zijlstra Geiske , Martin Guy , Baheerathan Aravindhan , Pratt Philip , Darzi Ara , Patel Nisha , Kinross James
Published: May 2022

BACKGROUND

COVID-19 has had a catastrophic impact in terms of human lives lost. Medical education has also been impacted as appropriately stringent infection control policies precluded medical trainees from attending clinical teaching. Lecture-based education has been easily transferred to a digital platform, but bedside teaching has not.

OBJECTIVE

This study aims to assess the feasibility of using a mixed reality (MR) headset to deliver remote bedside teaching.

METHODS

Two MR sessions were led by senior doctors wearing the HoloLens headset. The trainers selected patients requiring their specialist input. The headset allowed bidirectional audiovisual communication between the trainer and trainee doctors. Trainee doctor conceptions of bedside teaching, impact of the COVID-19 pandemic on bedside teaching, and the MR sessions were evaluated using pre- and postround questionnaires, using Likert scales. Data related to clinician exposure to at-risk patients and use of personal protective equipment (PPE) were collected.

RESULTS

Prequestionnaire respondents (n=24) strongly agreed that bedside teaching is key to educating clinicians (median 7, IQR 6-7). Postsession questionnaires showed that, overall, users subjectively agreed the MR session was helpful to their learning (median 6, IQR 5.25-7) and that it was worthwhile (median 6, IQR 5.25-7). Mixed reality versus in-person teaching led to a 79.5% reduction in cumulative clinician exposure time and 83.3% reduction in PPE use.

CONCLUSIONS

This study is proof of principle that HoloLens can be used effectively to deliver clinical bedside teaching. This novel format confers significant advantages in terms of minimizing exposure of trainees to COVID-19, reducing PPE use, enabling larger attendance, and delivering convenient and accessible real-time clinical training.
A Novel Framework for Mixed Reality–Based Control of Collaborative Robot: Development Study (Preprint)
Authors: Shahria Md Tanzil , Sunny Md Samiul Haque , Zarif Md Ishrak Islam , Khan Md Mahafuzur Rahaman , Modi Preet Parag , Ahamed Sheikh Iqbal , Rahman Mohammad H
Published: May 2022

BACKGROUND

Applications of robotics in daily life are becoming essential by creating new possibilities in different fields, especially in the collaborative environment. The potentials of collaborative robots are tremendous as they can work in the same workspace as humans. A framework employing a top-notch technology for collaborative robots will surely be worthwhile for further research.

OBJECTIVE

This study aims to present the development of a novel framework for the collaborative robot using mixed reality.

METHODS

The framework uses Unity and Unity Hub as a cross-platform gaming engine and project management tool to design the mixed reality interface and digital twin. It also uses the Windows Mixed Reality platform to show digital materials on holographic display and the Azure mixed reality services to capture and expose digital information. Eventually, it uses a holographic device (HoloLens 2) to execute the mixed reality–based collaborative system.

RESULTS

A thorough experiment was conducted to validate the novel framework for mixed reality–based control of a collaborative robot. This framework was successfully applied to implement a collaborative system using a 5–degree of freedom robot (xArm-5) in a mixed reality environment. The framework was stable and worked smoothly throughout the collaborative session. Due to the distributed nature of cloud applications, there is a negligible latency between giving a command and the execution of the physical collaborative robot.

CONCLUSIONS

Opportunities for collaborative robots in telerehabilitation and teleoperation are vital as in any other field. The proposed framework was successfully applied in a collaborative session, and it can also be applied in other similar potential applications for robust and more promising performance.
Cardiovascular Disease Prevention Education Using a Virtual Environment in Sexual-Minority Men of Color With HIV: Protocol for a Sequential, Mixed Method, Waitlist Randomized Controlled Trial (Preprint)
Authors: Ramos S Raquel , Johnson Constance , Melkus Gail , Kershaw Trace , Gwadz Marya , Reynolds Harmony , Vorderstrasse Allison
Published: May 2022

BACKGROUND

It is estimated that 70% of all deaths each year in the United States are due to chronic conditions. Cardiovascular disease (CVD), a chronic condition, is the leading cause of death in ethnic and racial minority males. It has been identified as the second most common cause of death in persons with HIV. By the year 2030, it is estimated that 78% of persons with HIV will be diagnosed with CVD.

OBJECTIVE

We propose the first technology-based virtual environment intervention to address behavioral, modifiable risk factors associated with cardiovascular and metabolic comorbidities in sexual-minority men of color with HIV.

METHODS

This study will be guided using social cognitive theory and the Technology Acceptance Model. A sequential, mixed method, waitlist controlled randomized control feasibility trial will be conducted. Aim 1 is to qualitatively explore perceptions of cardiovascular risk in 15 participants. Aim 2 is to conduct a waitlist controlled comparison to test if a virtual environment is feasible and acceptable for CVD prevention, based on web-based, self-assessed, behavioral, and psychosocial outcomes in 80 sexual-minority men of color with HIV.

RESULTS

The study was approved by the New York University Institutional Review Board in 2019, University of Texas Health Science Center at Houston in 2020, and by the Yale University Institutional Review Board in February 2022. As of April 2022, aim 1 data collection is 87% completed. We expect to complete data collection for aim 1 by April 30, 2022. Recruitment for aim 2 will begin mid-May 2022.

CONCLUSIONS

This study will be the first online virtual environment intervention for CVD prevention in sexual-minority men of color with HIV. We anticipate that the intervention will be beneficial for CVD prevention education and building peer social supports, resulting in change or modification over time in risk behaviors for CVD.

CLINICALTRIAL

ClinicalTrials.gov NCT05242952; https://clinicaltrials.gov/ct2/show/NCT05242952

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/38348
Website Usability of American Anesthesiology Residency Programs (Preprint)
Authors: Seto Noah , Beach Jeffrey , Calvano Joshua , Lu Shu , He Shuhan
Published: May 2022

BACKGROUND

Due to the changes brought by the coronavirus pandemic on medical education, many students will have limited in person exposure to Anesthesiology programs and will rely on information gleaned digitally. Consequently, program websites used to provide information will become crucial in helping students decide where and how to apply in the future.

OBJECTIVE

The primary goals of this study were to: 1) Identify United States anesthesiology residency programs and their websites; 2) Objectively analyze anesthesiology residency websites employing a formally published usability scoring system; 3) Identify positive and negative trends to offer areas of improvement amongst anesthesiology residency websites.

METHODS

We included 114 United States anesthesiology residency program websites in our sample. Website usability was separated into four distinct categories: Accessibility, Marketing, Content Quality, and Technology. Each website was then analyzed and scored based on components highlighted within the four categories. The factors were then graded using a percentage system to create a comprehensive score for each program.

RESULTS

The highest scoring category was Content Quality (mean 4.7, std +/- 2.48, SE 0.23). The lowest scoring category was Technology (mean 0.9, std +/- 0.38, SE 0.04).

CONCLUSIONS

Through the framework of healthcare website usability, multiple anesthesiology residency programs were analyzed and scored in the areas of Accessibility, Marketing, Content Quality, and Technology. We recommend that anesthesiology programs should improve website usability to increase the ease by which applicants collect information about their programs. Proposed solutions include improving Technology by decreasing error pages on websites, migrating away from using in-line cascading style sheets (CSS), and increasing web page loading speeds.
Emoji Education: How Students can Help Increase Health Awareness by Making Emojis (Preprint)
Authors: Marzouk Sammer , He Shuhan , Lee Jarome
Published: May 2022

UNSTRUCTURED

Throughout the past several years, there has been an increasing need for medical and health-related emojis to become more present in our society. Even as the total number of emojis increases every year, the number of health-related emojis continues to be the same. This lack of innovation within the field presents a great opportunity for innovation in the field of medical communication. As the world becomes more interconnected through electronic communication, there is a lot of potential for medical professionals to develop new artistic representations of health and medical topics through emojis. Emoji are beginning to be used in more pieces of health communication, such as patient guides, procedure summaries, and general signage throughout hospitals to great amounts of success. However, the limiting factor using emojis is the finite number of health-related emojis. In order to address this problem, we propose a call to action to medical professionals to begin developing new emojis based on their health expertise. Anyone is able to submit an emoji to the Unicode Standard, which is the body that collects and standardizes emojis. By going through the submission process, we can expand the representations of health emojis and make certain topics more accessible for a greater number of people. This can present a great method of allowing a wider array of access to medical information that might be locked behind complex and technical words. In the future, we hope to continue pushing for a greater number of Unicode Standard emojis that depict healthcare by describing how health professionals can draw and submit emojis.
A Digital Platform to Support HIV Case Management for Youth and Young Adults: Mixed Methods Feasibility Study (Preprint)
Authors: Fee Connie , Fuller Julia , Guss Carly E. , Woods Elizabeth R. , Cooper Ellen R. , Bhaumik Urmi , Graham Dionne , Burchett Sandra , Dumont Olivia , Marty Emily , Narvaez Maria , Haberer Jessica E. , Swendeman Dallas , Mulvaney Shelagh A. , Kumar Vikram S. , Jackson Jonathan L. , Ho Y. Xian
Published: May 2022

BACKGROUND

Advances in medical treatments in recent years have contributed to an overall decline in HIV-related opportunistic infections and deaths in youth; however, mortality and morbidity rates in perinatally and non-perinatally infected youth living with HIV (YLWH) remain relatively high today.

OBJECTIVE

The goal of this project is to assess the usage, utility, and cost-effectiveness of PlusCare, a mobile/web application (app) for HIV case management for YLWH. The app supports routine case management tasks such as scheduling follow-up visits, sharing documents for review and signature, lab test results, and between-visit communications (e.g., encouraging messages).

METHODS

We conducted a single-group mixed-methods, pre-post study conducted with HIV case management programs in 2 large, urban hospitals in the Boston metro area. Case management staff (CMs, N=20) and YLWH patients (N=45) participated in the study with access to PlusCare for up to 15 months and 12 months, respectively.

RESULTS

CMs and YLWH reported System Usability Scale scores of 51 (SD=7.9) and 63 (SD=10.6), respectively. Although marginally significant, total charges billed at one of the two sites compared to the 12 months prior to app use (including emergency, inpatient, and outpatient charges) decreased by 41% (P=.046). We also observed slight increases in YLWH self-reported self-efficacy (SEMCD6) and quality of life (CDC HRQOL-4) from baseline to 12-month follow-up (P=.02 and P=.03, respectively) and increases in self-efficacy from 6-month to 12-month follow-up (P=.02). There was no significant change in HIV viral suppression or appointment or medication adherence in this small sample pilot study.

CONCLUSIONS

While perceived usability was low, qualitative feedback from CMs and usage patterns suggest direct messaging and timely, remote, and secure sharing of lab results and documents (including electronic signatures) between CMs and YLWH can be particularly useful and have potential value in supporting care coordination and promotion of patient self-efficacy and quality of life.

CLINICALTRIAL

ClinicalTrials.gov NCT03758066
Primary Studies Published in Predatory Journals Are Frequently Included in Systematic Reviews Published in High-Impact Dermatology Journals: A Cross-Sectional Study (Preprint)
Authors: Ottwell Ryan , Hightower Brooke , Failla Olivia , Snider Kelsey , Corcoran Adam , Hartwell Micah , Vassar Matt
Published: May 2022

UNSTRUCTURED

No abstract required for research letter.
Nudging for distance - does it work? A case study on proximity detection technologies to support preventive behavior in a Swedish workplace during Covid-19 (Preprint)
Authors: Villius Zetterholm My , Nilsson Lina , Jokela Päivi
Published: May 2022

BACKGROUND

The recent Covid-19 pandemic has contributed to the emergence of several technologies for infectious disease management. Although much focus has been placed on contact tracing applications, another promising new tactic is proximity tracing that focuses on health-related behavior and can be used for primary prevention. Underpinned by theories on behavioral design, a proximity detecting system can be devised that provides a user with immediate nudges to maintain physical distance to others. The practical feasibility of proximity detection during an infectious disease outbreak has not been sufficiently investigated.

OBJECTIVE

To evaluate the feasibility of using a wearable device to nudge for distance, and to gather important insights about how the functionality and interaction were experienced by the users. The results from this study can guide future research and design efforts in this emerging technology.

METHODS

This retrospective case study uses a mixed methods approach including interviews (n=8) and a survey (n=30), to compile the experiences of an event project which used a wearable proximity detecting technology to nudge users with auditory feedback to maintain a safe physical distance in their workplace.

RESULTS

Themes were generated from qualitative analysis based on data from interviews and survey open-text responses. The quantitative data was subsequently integrated into these themes: Feasibility (Implementation & Acceptance – Establishing a Shared Problem; Distance Tags in Context – Strategy, Environment and Activities; Understanding and Learning; Accomplishing the Purpose), and Design aspects (A Purposefully Annoying Device; Timing, Tone, and Proximity; Additional functions).

CONCLUSIONS

This empirical study establishes the feasibility of using a wearable technology to nudge individuals to maintain a safe distance in their workplace during a pandemic. The usability of the technology is dependent on context, situation, and user's ability to adapt. At certain situations the audio signal is experienced as frustrating, but most users agree that it needs to be annoying to ensure a sufficient behavioral adaption. We propose a dual nudge that involves a vibration followed by a sound. There are indications that the technology facilitates learning, and that the preventive distancing behavior can persist beyond the context of use. This study demonstrates that the key value of this technology is that it places the user in control and enables immediate action in a situation when distance to others is not maintained. The study contributes to the emerging field of personal and wearable technologies used for primary preventive purposes during infectious disease outbreaks. Future research is needed to evaluate the preventive effect, and to investigate behavior change in more detail and in relation to different forms of feedback.
Assessing a New Prescreening Score for the Simplified Evaluation of the Clinical Quality and Relevance of eHealth Apps: Instrument Validation Study (Preprint)
Authors: Wagneur Nicolas , Callier Patrick , Zeitoun Jean-David , Silber Denise , Sabatier Remi , Denis Fabrice
Published: May 2022

BACKGROUND

In 2020, more than 250 eHealth solutions were added to app stores each day, or 90,000 in the year; however, the vast majority of these solutions have not undergone clinical validation, their quality is unknown, and the user does not know if they are effective and safe. We sought to develop a simple prescreening scoring method that would assess the quality and clinical relevance of each app. We designed this tool with 3 health care stakeholder groups in mind: eHealth solution designers seeking to evaluate a potential competitor or their own tool, investors considering a fundraising candidate, and a hospital clinician or IT department wishing to evaluate a current or potential eHealth solution.

OBJECTIVE

We built and tested a novel prescreening scoring tool (the Medical Digital Solution scoring tool). The tool, which consists of 26 questions that enable the quick assessment and comparison of the clinical relevance and quality of eHealth apps, was tested on 68 eHealth solutions.

METHODS

The Medical Digital Solution scoring tool is based on the 2021 evaluation criteria of the French National Health Authority, the 2022 European Society of Medical Oncology recommendations, and other provided scores. We built the scoring tool with patient association and eHealth experts and submitted it to eHealth app creators, who evaluated their apps via the web-based form in January 2022. After completing the evaluation criteria, their apps obtained an overall score and 4 categories of subscores. These criteria evaluated the type of solution and domain, the solution’s targeted population size, the level of clinical assessment, and information about the provider.

RESULTS

In total, 68 eHealth solutions were evaluated with the scoring tool. Oncology apps (22%, 20/90) and general health solutions (23%, 21/90) were the most represented. Of the 68 apps, 32 (47%) were involved in remote monitoring by health professionals. Regarding clinical outcomes, 5% (9/169) of the apps assessed overall survival. Randomized studies had been conducted for 21% (23/110) of the apps to assess their benefit. Of the 68 providers, 38 (56%) declared the objective of obtaining reimbursement, and 7 (18%) out of the 38 solutions seeking reimbursement were assessed as having a high probability of reimbursement. The median global score was 11.2 (range 4.7-17.4) out of 20 and the distribution of the scores followed a normal distribution pattern (Shapiro-Wilk test: P=.33).

CONCLUSIONS

This multidomain prescreening scoring tool is simple, fast, and can be deployed on a large scale to initiate an assessment of the clinical relevance and quality of a clinical eHealth app. This simple tool can help a decision-maker determine which aspects of the app require further analysis and improvement.
The Effectiveness of Red Fruit Oil (Pandanus conideus Lamk.) Emulgel on the Acceleration of the Incision Wound Healing Process
Authors: Inayatilah Fidia Rizkiah , Guhir Abdul Malik , Atmaja Ria Ramadhani Dwi
Published: May 2022

Incision wounds have a fairly high prevalence in Indonesia. Chemical treatment of incision wounds has adverse side effects, therefore alternative treatment with natural ingredients is needed, namely using red fruit oil as the basic ingredient. The purpose of this study is to determine the effectiveness of red fruit oil (Pandanus conoideus­­ Lamk.) gel emulsion on the healing process of incision wounds in males both macroscopically and microscopically. This is an experimental laboratory study. The study design used was true experimental with a post-test-only control group design approach. The population consisted of 25 male mice which were divided into 5 groups, namely: (1) K- was a control group where the incision wound on the back was given a gel emulsion base; (2) K+ was the control group where the incision wound on the back was given Iodine Povidone ; (3) P1 is the treatment group where the incision wound on the back is given a 5% red fruit oil gel emulsion (F1); (4) P2 is the treatment group where the incision wound on the back is given a red fruit oil gel emulsion 10% (F2); (5) P3 was the treatment group where the incision on the back was given a 15% red fruit oil gel emulsion (F3). The treatment was given for 14 days. The data were then analyzed using the ANOVA test. The result showed that the administration of red fruit oil emulgel had a significant effect on the size of the incision wound on the 7th day (p=0.035) and the 14th day (p=0.005). Giving red fruit oil emulgel also had a significant effect on the thickness of the epithelium (p=0.000) and the number of fibroblasts (p=0.000). It can be concluded that the administration of red fruit oil emulgel affects the healing process of the incision wound both macroscopically and microscopically.
Development of Nanoparticles Pegagan Leaves Ethanolic Extract (centella asiatica (L.) Urban) using Variation Concentration of Poly-Lactic-CO-Glycolic Acid (PLGA) Polymer
Authors: Apriani Elsa Fitria , Mardiyanto Mardiyanto , Destiana Rika
Published: May 2022

Pegagan is a plant that plays an important role in health because of its secondary metabolite. However, many secondary metabolites tend to be unstable when exposed to UV light and oxygen such as flavonoid and terpenoid. The purpose of this study was to formulate the ethanolic extract of pegagan leaves into nanoparticle preparations to increase the stability of the extract. Nanoparticle preparations were made using the emulsion solvent evaporation method using Poly-Lactic-Co-Glycolic Acid (PLGA) and polyvinyl alcohol (PVA). PLGA acts as a polymer that will coat the extract and PVA as a stabilizer. Variations in the concentration of PLGA used were 50 mg, 75 mg, and 100 mg, while the concentration of PVA used was 40 mg and the extract concentration was 158 mg. Determination of the best formula is done by looking at the results of the percent encapsulation efficiency obtained from the three formulas, namely 93.68%, 85.35%, and 88.76%, respectively. Based on these results, formula 1 was determined as the best formula. The particle size obtained in the best formula was 288.1667±3.4195 nm, the polydispersity index (PDI) was 0.371±0.0045 and the zeta potential value was -10.6333±0.1154. A physical stability test (cycling test method) of the best formula found a decrease in pH of 0.54 and no organoleptic changes or precipitate formed.
Parental Involvement on Child’s Education at Home during COVID-19 Pandemic
Authors: Bonilla Marlon Toren , Camo Jemajo Guban , Lanzaderas Rhea Alvarez , Lanzaderas Riza Alvarez , Bonilla Anita Heredero
Published: May 2022

As the COVID-19 pandemic strikes, the Philippine educational system has been interrupted, with regular classrooms being replaced with distance learning. Parents are compelled to act as teachers or tutors in their children's home education. This study aims to find out how parents participate in distance learning at the height of the pandemic. This research used a descriptive-correlational research design. Researcher-made questionnaires were used to collect data from 60 parents chosen through stratified intentional sampling. Data were analyzed using descriptive statistics and Kendall’s Tau B for correlations. Findings revealed that family income and parental educational attainment are related to parental involvement. Parental educational attainment and barriers are quite important. Parental educational attainment and parental involvement with barriers are quite important. Family income with barriers is insignificant. The biggest difficulties that parents found were internet connectivity, lack of devices or gadgets, access to the internet, and difficulty instructing their children at home. It is suggested that the Department of Education adopt and stay current with distance learning education as a supplement to traditional methods of teaching-learning to ensure continuity during difficult times. In every situation, parents must accept the critical role of becoming involved in their child's learning process.
El deber de profesionalidad como elemento determinante del estándar de diligencia en el derecho del consumo
Authors: Gatica Rodríguez María Paz , Morales Ortiz María Elisa
Published: May 2022

The selected judgement refers to the so-called “duty of professionalism” as an element to take into account in determining providers’ liability. The comment intends to delineate the content of the duty of professionalism and its consequences, especially with regard to the standard of diligence due by providers.