bluuebunny/crossref_metadata_2025 huggingface dataset:
THE STATE POSITION AS A PREFERENT CREDITOR OF THE TAX DEBT IN BANKRUPTCY
Authors: Damayanti Ratih
Published: September 2019

Bankruptcy is a decision issued by the Court that resulted in a general confiscation of all the wealth owned and the wealth that will be owned by the debtor in the future. The State has the preference right to tax debt on the property of the Taxpayer. This means that the position of the state as a preferent creditor who is declared to have prior rights over the property of the Taxpayer to be auctioned in public. The state's preference by taxpayer repayment is in fact not as easy as one might imagine, there are some problems. The purpose of article writing is to know the position of the State as a preferent creditor for the tax debt of the taxpayer declared bankrupt and know the obstacles of the State as a preferent creditor to the repayment of tax debt on taxpayers declared bankrupt. Provisions on the State's prior rights include the principal taxes, administrative sanctions in the form of interest, penalties, increases, and tax collection fees. The weakness in the regulation creates an impediment to the application of the State as a preferential creditor who has the preference right, namely the formulation of the preference right itself that is unclear about the notion of the state's position as the preferent creditor, in addition to the overlapping regulation of the preference right (preferent creditor) The Civil Code, the Law on General Taxation and Bankruptcy Laws and Postponement of Debt Payment Obligations which not only the State as the Preference rights holder's creditors.
PROTECTION IN RETAIL INVESTORS DISADVANTED BY FAKE TRANSACTION PRACTICE (CORNERING THE MARKET)
Authors: ARGIYANTO DESTU
Published: September 2019

The practice of fake transaction is a stock trading practice that incurs many losses, especially for retail investors who basically do not control the market in majority on the floor of the stock. This practice may threaten the liquidity and credibility of capital market activities in Indonesia. Pseudo transaction is one of the crimes prohibited in Capital Market Law which fall into the category of market manipulation. In simple terms, market manipulation is an activity undertaken by a person either directly or indirectly creating a false or misleading image of a trading activity, market situation, or price of Securities at a Stock Exchange or giving a statement, or an improper, or misleading statement so that the price of the securities in bursa affected. Provisions on market manipulation are provided in Articles 91, 92 and 93 of Law Number 8 of 1995 concerning the Capital Market.Keywords : Concerning the market, Ritel Investors, Protection
The Civil Law Review Of The Role Of Joint Village-Owned Business Entities (BUM Desa Bersama) As the Subject of Civil Law
Authors: Saraya Sitta
Published: September 2019

Village development in Indonesia demands a growing system of regulations both in the field of village development and its economy so that since the enactment of Law Number 6 of 2014 concerning Villages, Village-Owned Enterprises (BUM Desa) have emerged to support economic development and development of a village in Indonesia . BUM Desa is a Legal Entity that can carry out legal actions to manage capital and assets owned, provide general public services in the form of drinking water management, village waste management, management of barns, making ponds, managing plantation products and livestock products, utilizing tourism potential into villages tourism and other business activities that involve the active role of independent village communities, establish partnerships and cooperation with other parties, both individuals and other legal entities such as Limited Liability Companies, CVs and so on. The purpose of this study is to find out the role of the role of the Joint Village Business Entity as the subject of Civil Law in carrying out various legal actions including cooperating in various fields with other business entities incorporated.Keywords: Civil Law, Joint Village Owned Enterprises (BUM Desa Bersama), Subjects of Civil Law
Fondasi Ilmu Hukum Berketuhanan: Analisis Filosofis terhadap Ontologi, Epistemologi, dan Aksiologi
Authors: Ali Mahrus
Published: September 2019

Ketuhanan Yang Maha Esa ditempatkan sebagai sila pertama Pancasila. Implikasinya, pembaharuan, pembentukan, dan penegakan hukum di Indonesia harus bersumber pada nilai yang terkandung di dalam sila pertama tersebut. Penelitian ini bertujuan untuk secara filosofis menganalisis ontologi, epistemologi, dan aksiologi ilmu hukum berketuhanan. Penelitian ini merupakan penelitian hukum normatif dengan pendekatan filosofis dan konseptual. Hasil penelitian ini mengungkap bahwa hakikat ilmu hukum berketuhanan adalah ilmu hukum yang dikembangkan berbasis pada nilai-nilai ketuhanan. Ia bukanlah ilmu hukum yang sekuler yakni ilmu hukum yang melepaskan diri nilai-nilai moral dan agama, melainkan ilmu hukum yang menjadikan nilai-nilai moral dan agama sebagai fondasi dalam pembaharuan, pembentukan, dan penegakan hukum. Kebenaran pengetahuan menurut ilmu hukum berketuhanan beranjak dari kebenaran firman Tuhan yang diwujudkan dalam bentuk nilai-nilai Pancasila yang selaras dengan nilai-nilai budaya bangsa Indonesia. Kebenaran di sini tidak hanya mengacu kepada kebenaran korespondensi, kebenaran koherensi, dan kebenaran pragmatis, tapi juga menjadikan ketiganya menyatu di bawah payung kebenaran ilahiah. Sedangkan nilai yang hendak diwujudkan oleh ilmu hukum berketuhanan sedemikian komperensif yang memuat semua nilai-nilai bangsa Indonesia baik yang religius maupun yang kultural. Nilai-nilai ini sudah dipraktikkan sejak lama oleh bangsa Indonesia sebelum merdeka. Meskipun nilai-nilai itu universal dan abstrak, tapi ia sudah mendarah daging dan menjiwai kehidupan sehari-hari bangsa Indonesia.Believing in the only and one God is set as the first pillar of Pancasila. This will have an implicate that the law reform, law making, and law enforcement must refer to the values. This article is aimed at analysing the ontology, epistemology, and axiology of God law. This research is normative legal research, white the approach used is both philosopical and conceptual. This article reveals that the essence of God law is the law founded by the values of God. It combines the values of morality and religion. The truth of knowledge stands from the truth of Gods sayings and is manifested in the form of values of Pancasila which are in accordance with the cultural values of Indonesia. The absolute truth of Gods sayings is a combination of correspondence, coherence, and pragmatic rightness. Finally, the value directed by the Gods law is so comprehensive consisting all Indonesian values religiously and culturally which have been practised at long time. Although these values are universal dan abstract, they have been embedded in the soul and daily life of Indonesian people.
Problematika Kebijakan Syariat Islam di Aceh Berdasarkan Peraturan Bupati Nomor 5 Tahun 2010
Authors: Mardhiah Nellis
Published: September 2019

Peraturan Bupati Nomor 5 Tahun 2010 tentang Peraturan Penegakan Syariat Islam dalam pemakaian busana Islam di Kabupaten Aceh Barat. PERBUP ini adalah menjadi pokok permasalahan yang utama dalam penelitian ini. Penerapan peraturan tersebut menjadi kontradiksi di kehidupan masyarakat dalam memahami dan mematuhi kebijakan tersebut. Permasalahan lain dalam qanun syariat islam yang diterapkan di Provinsi Aceh dan khususnya Kabupaten Aceh Barat adalah belum diberlakukannya aturan kepada Warga Negara Asing yang melanggar norma-norma syariat islam. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis permasalahan sosial yang dialami masyarakat terkait pelaksanaan peraturan Syariat Islam di masyarakat Aceh Barat. Pendekatan penelitian ini menggunakan kualitatif. Hasil penelitian ini menunjukkan bahwa permasalahan sosial penerapan Syariat Islam di Kabupaten di Aceh Barat pasca pemberlakukan peraturan Bupati Nomor 5 Tahun 2010 belum berjalan secara maksimal karena terjadi peningkatan kasus-kasus yang signifikan dari tahun 2011-2015. Pelanggaran-pelanggaran terhadap penerapan syariat Islam tersebut diantaranya disebabkan oleh kelemahan sosialisasi ke masyarakat dalam penerapan kebijakan dan kurangnya anggaran operasional, sehingga implementasi kebijakan tidak berjalan dengan baik. Selain itu ada juga intervensi kelompok aktivis Hak Asasi Manusia yang meyakini bahwa hukum syariat Islam yang diterapkan di Aceh adalah melanggar HAM.Regent Regulation No. 5 of 2010 on the Regulation of Enforcement of Islamic Sharia in the use of Islamic dress in the District of West Aceh. This is a key issue in this research. The implementation of the regulation becomes a contradiction in the life of the community in understanding and complying with the policy. Another problem in qanun syariat Islam that is applied in Aceh Province and especially West Aceh regency is not yet enforced rules to foreign citizen who violate norms of Islamic sharia. This study aims to identify and analyze social problems experienced by the community related to the implementation of Islamic Sharia rules in the people of West Aceh. This research approach uses qualitative. The results of this study indicate that the social problem of the implementation of Islamic Sharia in the District in West Aceh after the enactment of Regulation No. 5 of 2010 has not been running maximally due to the increase of significant cases from 2011-2015. Violations against the implementation of Islamic Sharia are caused by the weakness of socialization to the community in the implementation of the policy and the lack of operational budget, so the implementation of the policy is not going well. In addition there are also intervention groups of human rights activists who believe that Islamic sharia law applied in Aceh is a violation of human rights.
Politik Hukum Perlindungan Pekerja Migran Perempuan di Indonesia
Authors: Natalis Aga , Ispriyarso Budi
Published: September 2019

Penelitian ini bertujuan untuk menganalisis bagaimana politik hukum perlindungan pekerja migran perempuan berbasis teori hukum feminis di Indonesia. Penelitian ini menggunakan pendekatan yuridis normatif. Hasil kajian menunjukkan bahwa Politik hukum perlindungan terhadap pekerja migran perempuan, dapat ditelusuri berdasarkan beberapa regulasi terkait, mulai dari tatanan ideal, konstitusional, legislasi dan implementasi. Undang-undang perlindungan pekerja migran dianggap belum mampu melindungi pekerja migran perempuan Indonesia, tidak ada peraturan khusus terkait perlindungan pekerja migran perempuan dan belum konsisten untuk mengimplementasi berbagai konvensi yang telah diratifikasi terkait perlindungan pekerja migran terutama perempuan, sehingga perlu ditetapkan peraturan khusus terkait perlindungan pekerja migran Indonesia dalam rangka mewujudkan instrumen hukum perlindungan pekerja migran yang responsif terhadap kebutuhan pekerja migran perempuan Indonesia. Teori hukum feminis mendesak, pemerintah untuk menciptakan regulasi, terutama terkait perlindungan pekerja migran perempuan yang menempatkan perempuan pada posisi yang istimewa. This research aims to analyze how is the politics of law of the protection of female migrant workers is based on the feminist legal theory in Indonesia. This research uses a normative juridical approach. The results of the study indicate that the politcs of law of the protection of female migrant workers can be traced based on several related regulations, ranging from ideal, constitutional, legislative and implementation arrangements. The law on the protection of migrant workers is deemed unable to protect Indonesian female migrant workers, there are no specific regulations relating to the protection of female migrant workers and has not been consistent in implementing ratified conventions related to the protection of migrant workers, especially women, so special regulations need to be stipulated regarding migrant workers protection Indonesia in order to realize a legal instrument for the protection of migrant workers who is responsive to the needs of Indonesian women migrant workers. Feminist legal theory urges the government to create regulations, especially related to the protection of female migrant workers who place women in a special position.
Bone mineral density, body composition and metabolic profiles in adult women with complete androgen insensitivity syndrome and removed gonads using oral or transdermal estrogens
Authors: Gava Giulia , Mancini Ilaria , Orsili Isabella , Bertelloni Silvano , Alvisi Stefania , Seracchioli Renato , Meriggiola Maria Cristina
Published: September 2019

Objectives

To assess bone health in adult women with complete androgen insensitivity syndrome (CAIS) and removed gonads compared with age-matched healthy controls. To evaluate the effects of transdermal oestradiol 2 mg or oral estradiol valerate 2 mg on bone, biochemical and clinical characteristics.

Design

Cohort study.

Methods

Bone, body composition and anthropometric parameters were assessed in 32 adult CAIS and 32 healthy controls. In 28 cases, CAIS evaluations of metabolic, bone and body composition were performed also after a maximum of 6 years of therapy.

Results

Lumbar, femoral and total body bone mineral density (BMD) were significantly lower in those with CAIS when compared with controls. The prevalence of vertebral osteoporosis and osteopenia was significantly higher in the CAIS group (P = 0.038, OR = 9.67, 95% CI: 1.13–82.83 and P = 0.012, OR= 3.85, 95% CI: 1.34–11.16, respectively). Prevalence of femoral osteopenia was significantly higher in the CAIS group (P = 0.0012, OR = 7.93, 95% CI: 2.26–27.9). During follow-up, lumbar BMD significantly increased suggesting a significant effect of treatment on BMD (P = 0.0016), while femoral and total body BMD did not show any significant change. Total body BMD values were positively associated to the duration and route of oestrogen administration and to serum estradiol levels. Transdermal administration of estrogens was associated with better total body BMD in comparison to oral administration.

Conclusions

Our results reinforce the importance of adequate hormonal treatment for women living with CAIS, suggesting a better effect from the transdermal route over the oral route.
Overexpression of BnaAOX1b Confers Tolerance to Osmotic and Salt Stress in Rapeseed
Authors: Yang Hongli , Deng Linbin , Liu Hongfang , Fan Shihang , Hua Wei , Liu Jing
Published: September 2019

Alternative oxidases (AOXs) are the terminal oxidase in the cyanide-resistant respiration pathway in plant mitochondria, which play an important role in abiotic stress and are proposed as a functional marker for high tolerant breeding. In this study, ten AOX genes (BnaAOXs) were identified, and CysI and CysII of AOX isoforms were highly conserved in rapeseed. Among them, Bna.AOX1b was mainly expressed in the ovule and displayed varying expression between rapeseed cultivars which showed different salt resistance in seed germination. We identified its mitochondrial localization of this gene. To investigate the function of BnaAOX1b in rapeseed, transgenic rapeseed lines with overexpressed BnaAOX1b were created and seed germination and seedling establishment assays were performed under osmotic, salt, and ABA treatment. The results indicated that overexpression of BnaAOX1b significantly improved seed germination under osmotic and salt stress and weakened ABA sensitivity. In addition, post-germination seedling growth was improved under high salt condition, but showed hypersensitivity to ABA. RNA-sequencing analysis indicated that the genes involved in electron transport or energy pathway were induced and a number of gene responses to salt stress and ABA were regulated in Bna.AOX1b overexpressing seeds. Taken together, our results imply that Bna.AOX1b confers tolerance to osmotic and salt stress in terms of seed germination and seedling establishment by regulating stress responsive genes and the response to ABA, and could be utilized as a candidate gene in transgenic breeding.
Anspruch auf Zugang zu Informationen des Bundeskartellamts aus einem abgeschlossenen Fusionskontrollverfahren nach § 1 IFG
Authors: Wirtz Markus , Schmidt Ulrich
Published: September 2019

Mit dem vor kurzem veröffentlichten Urteil des BVerwG vom 9. 5. 2019, Az. 7 C 34.17, wurde zum ersten Mal höchstrichterlich die Frage behandelt, ob ein Informationsanspruch nach § 1 Abs. 1 Informationsfreiheitsgesetz (IFG) in Bezug auf Informationen des BKartA aus einem Fusionskontrollverfahren besteht. Konkret ging es um den Zugang eines nicht beigeladenen Dritten zum Votum des Berichterstatters. Das BVerwG hat das Bestehen eines Informationsanspruchs wegen des Ausschlussgrunds nach § 3 Nr. 3 lit. b IFG verneint. Dieser Beitrag greift das Urteil auf und geht – abstrahiert von dem der Entscheidung zugrunde liegenden konkreten Sachverhalt – der Frage nach, unter welchen Voraussetzungen ein Anspruch auf Zugang zu Informationen des Bundeskartellamts aus einem Fusionskontrollverfahren besteht.
Metrology: where do we stumble?
Authors: Адлер Ю. П.
Published: September 2019

The article presents the main milestones in the development of the science of metrology, identifies the controversial and difficult aspects of the development of this area of ​​scientific knowledge. The goals and objectives of metrology are described in detail, the applied aspects of a peculiar methodological crisis in metrology are revealed. An analysis of a set of issues related to measurements is presented, which clearly confirms the crisis in applied metrology.Issues related to the process of carrying out measuring procedures are considered, and algorithms for performing measurements in accordance with the rules and procedures for servicing (checking) equipment are presented. Measurement operations are presented systematically, that is, taking into account the complex relationships of standards, statistical samples, etc. The article is replete with numerous historical examples and interesting remarks.The article considers such important aspects as joint training, issues of developing a single terminological base and developing adequate statistical databases. The article is supplied with working cases of calculations of significant values ​​for the analysis. The issues related to monitoring changes in the characteristics of the system being measured are considered in detail. The article clarifies aspects of this activity as an element of quality management. The issues of experiment planning in the field of metrology are also considered. The article is polemical.It is concluded that metrology is in the way of big changes. These changes are in the air, can be traced in solving various problems. The purpose of the article is to describe the state that metrology is currently experiencing, identify key points and controversial points. And in essence - to simulate the first steps that will allow changes in metrology to be realized.
Critique of the Theory and Practice of Bureaucracy
Authors: Демченко Л. Д.
Published: September 2019

The article examines the critical views on the bureaucracy of political philosophers and experts in thefield of public administration, from the end of the eighteenth century to the present day. The emphasis is onthe fact that phenomenon and concept of bureaucracy is one of the most discussed and analyzed within thescience of public administration. Despite the historical stability and evolution of the theoretical foundationsof bureaucracy, the latter is increasingly criticized by researchers. The analysis of critical sources ofbureaucracy as a scientific model and the practical organization of a public administration confirms the ideaof the non-relevance of bureaucratic management mechanisms in the context of modern, dynamic socialtransformations.The goal of the paper is to comprehensively analyze critical assessments of the bureaucracy at the levelof theory and practice, to systematize the dysfunctional characteristics of the bureaucracy as a form ofadministration.The analysis of the papers of such scholars as Ch. Barnard, Ch. Goodsell, R. Hummel, R. Merton, M.Meyer, etc. shows that the disadvantages of the bureaucratic model of public administration include itsmechanistic character, absoluteness of rationality, antihumanism, and formalization of procedures. Today,most scholars recognize the need to establish a post-bureaucratic (postmodern) model that recognizes theprimacy of a person (citizen) over the state apparatus, the need for his / her active involvement in publicpolicy, efficiency and effectiveness as the main criteria for the quality of public administration activities, etc.Another form of critique of bureaucratic practice is the researches of gender scholars. These criticalremarks, above all, are due to the rejection of the rationalist-modern form of organization, as a definitelymale center.
Invarianza de Medición y Estructural de la Escala Básica de Empatía Breve (BES-B) en Niños y Adolescentes Peruanos
Authors: Merino-Soto Cesar , López-Fernández Verónica , Grimaldo-Muchotrigo Miriam
Published: September 2019

El objetivo del presente estudio fue examinar la invarianza de medición y la invarianza estructural de una medida de empatía, para niños y adolescentes peruanos. Los participantes fueron 417, provenientes de Lima Metropolitana. Se aplicó la Escala Básica de Empatía Breve (BES-B) de manera estandarizada. El análisis  consistió en aplicar el modelamiento de ecuaciones estructurales para evaluar la invarianza de medición y las medias latentes en los constructos de empatía afectiva y cognitiva. Los resultados muestran que la invarianza de medición se mantiene satisfactoriamente de acuerdo al género y la edad; las diferencias en las medias latentes muestran ser entre fuertes o moderadas respecto a la edad y el sexo. Se discuten las implicaciones teóricas y prácticas.
Satisfacción Laboral en el Docente Dominicano: Antecedentes Laborales
Authors: Tomás Jose M. , De los Santos Saturnino , Fernández Irene
Published: September 2019

La satisfacción laboral del colectivo docente ha sido estudiada desde diversas perspectivas, debido a los importantes efectos que esta puede tener tanto a nivel económico como a nivel organizacional. La muestra empleada en este trabajo se compone de 978 docentes dominicanos, y fue obtenida mediante un muestreo estratificado, y, por tanto, representativo de la población. En este estudio se examina un modelo de ecuaciones estructurales en el cual el contexto de trabajo y las condiciones laborales afectan el burnout y el engagement de los profesores. A su vez, se plantea que burnout y engagement afectan la satisfacción laboral docente. El modelo ajustó a los datos: χ2(223)= 1089.9, p<.001; CFI=.93; RMSEA=.066;SRMR=.107. Los resultados arrojan luz sobre los factores contextuales del plano educativo que pudieran replantearse en el desarrollo de futuras políticas educativas.
How Do Couples Disagree? An Analysis of Conflict Resolution Profiles and the Quality of Romantic Relationships
Authors: Delatorre Marina Zanella , Wagner Adriana
Published: September 2019

This study aimed to identify conflict resolution profiles and assess relationship quality levels associated with each profile. The participants were 750 heterosexual couples living in southern Brazil. They filled out measures about conflict resolution strategies, relationship quality, and sociodemographic data. A latent profile analysis was conducted in order to classify participants regarding conflict resolution. Variance and association analyses were also conducted in order to examine relationships between the resolution profiles and other study variables. Four profiles were identified: Low Conflict/Withdraw, Validator, Hostile, and Volatile. The Validator profile showed higher relationship quality, followed by Low Conflict/Withdraw and Volatile profiles, which did not differ from each other, and the Hostile, which showed low levels of relationship quality. We conclude that even though validation and negotiation are desirable, emotionally intense strategies may also be beneficial for couples in some contexts.
The Importance of Oriental Cults in Antium
Authors: Venetucci Beatrice Palma , Cacciotti Beatrice , Mangiafesta Maria
Published: September 2019

This paper discusses the preliminary results of a research project, concerning Egyptian statues and Mithraic monuments, which were probably discovered in Antium and obtained by chance by local collectors or sold by antiquarians after scarcely documented excavations through the 17th–18th centuries.
Mithras in Regio VI, Umbria
Authors: Bastianelli Giovanna
Published: September 2019

The presence of Mithras in Regio VI, Umbria, is documented by materials (some inscriptions, two arae, two reliefs, two tauroctonies: one of them fragmentary, the other one almost complete) which were either fortuitously unearthed between the 18th and the 19th century without any further research following, or discovered during unsystematic excavations – in both cases, they ended up lost (or simply forgotten) among the other pieces of family collections. This is how Marquis Eroli and Count Valenti bought, respectively, a relief now kept at the Museo Archelogico in Terni and a fragmentary tauroctony, still visible today in the hall of his ancestral palace in Trevi; Count Ramelli retrieved a tauroctony and some inscriptions in Sentinum: the tauroctony was then walled in the hall of his palace in Fabriano and the inscriptions were collected in the lapidarium of the palace. Finally, Count Marignoli promoted the excavation of the Mithraeum in Spoleto, dug up by Fabio Gori and documented in drawings and watercolors by the architect Silvestri; currently that Mithraeum has been reduced to a shapeless heap of rubble and its materials are not to be found anywhere.

This is definitely a distressing situation which, however, allows us to outline at least a Mithraic geography in Umbria made up of places along the Via Flaminia, east and west, where initiates to the Mithraic cult used to live, from Ocriculum to Interamna Nahars, Montoro, Spoletium, Trebiae, Carsulae and Sentinum, on the junction of the road coming from Helvillum. As for the cultores Mithrae in Regio VI, the few surviving inscriptions speak about them. There are freemen and freedmen, few slaves, some artisans, maybe some landowners or administrators of private and public estates who live and work at in-between towns and villae. They participate in the cult by covering various functions and supporting it financially: the leones in Carsulae collect money to build their leonteum; Sextus Egnatius Primitivus pays out of pocket to rebuild a spelaeum destroyed by an earthquake, while the thirty-five patroni of Sentinum contribute in different ways to the needs of their community.
Ernő Dohnányi's Library and Music Collection
Authors: Laskai Anna
Published: September 2019

It is not an easy task to reconstruct the library and music collection of a composer, whose homes – from Hungary through some European cities and South America to the United States – cannot be counted on the fingers of both hands. This paper investigates the story of Ernő Dohnányi's music collection and music library: summarizes the stages of Dohnányi's life, where he stayed for a longer period of time, therefore makes it possible to round up a considerable library and also discusses the lists, which give account of the items of the composer's books and scores. These lists preserved about the content of Dohnányi's previous Hungarian books and music collections of the Széher út villa, the music collection on Városmajor utca (the house of Dohnányi's sister), and about the library and music collection of the Dohnányis' Tallahassee home. The author of this paper could use the items of Dohnányi's books and scores, which the composer possessed in the final decade of his lifetime, too. At present, these documents, Dohnányi's American Estate is in the care of the Archives for 20th–21st Century Hungarian Music of the Institute for Musicology, Research Centre for Humanities of the Hungarian Academy of Sciences, Budapest. Beside the lists, the correspondence between Dohnányi and his sister, Mici, also contains information about the story of Dohnányi's libraries and music collections. This overview follows Dohnányi's collection even during the American years when he wanted to receive volumes of his former library, and understandably wanted to establish as rich a library as he had in his previous homes.
Future energy, fuel cells, and solid-oxide fuel-cell technology
Authors: Minh Nguyen Q. , Shirley Meng Y.
Published: September 2019

According to the US Department of Energy’s Energy Infomation Administration (EIA) (International Energy Outlook 2017), world energy consumption will increase 28% between 2015 and 2040, rising from 575 quadrillion Btu (∼606 quadrillion kJ) in 2015 to 736 quadrillion Btu (∼776 quadrillion kJ) in 2040. EIA predicts increases in consumption for all energy sources (excluding coal, which is estimated to remain flat)—fossil (petroleum and other liquids, natural gas), renewables (solar, wind, hydropower), and nuclear. Although renewables are the world’s fastest growing form of energy, fossil fuels are expected to continue to supply more than three-quarters of the energy used worldwide. Among the various fossil fuels, natural gas is the fastest growing, with a projected increase of 43% from 2015 to 2040. As the use of fossil fuels increases, the EIA projects world energy-related carbon dioxide emission to grow from ∼34 billion metric tons in 2015 to ∼40 billion metric tonnes in 2040 (an average 0.6% increase per year).
Participação nas eleições presidenciais de 2014: eleitores de Salvador usuários do Facebook e WhatsApp
Authors: Santana Rosane Soares
Published: September 2019

Este estudo investiga o uso do Facebook e do WhatsApp pelos eleitores de Salvador, no processo de engajamento cívico e participação política, durante as eleições presidenciais em 2014. Mede os níveis de participação on-line e off-line dos eleitores usuários das duas plataformas digitais e a correlação das variáveis sociodemográficas, renda familiar, frequência de acesso à internet, interesse político e preferência partidária com este processo. Os dados foram obtidos através de uma survey realizada em Salvador, em janeiro de 2015, que investigou diversas variáveis sobre o uso das Tecnologias da Informação e da Comunicação (TICs) no processo decisório eleitoral. Os resultados demostraram que os eleitores usuários do Facebook sobreposto ao WhatsApp foram mais participativos do que os eleitores que usaram separadamente o site de relacionamento ou o dispositivo de mensagens instantâneas. O estudo revelou ainda que o Facebook pode funcionar como uma plataforma alternativa para a participação dos eleitores de faixa etária mais avançada e que seus usuários foram os que mais se expressaram politicamente durante as eleições.
Partial Multi-Label Learning via Credible Label Elicitation
Authors: Fang Jun-Peng , Zhang Min-Ling
Published: September 2019

In partial multi-label learning (PML), each training example is associated with multiple candidate labels which are only partially valid. The task of PML naturally arises in learning scenarios with inaccurate supervision, and the goal is to induce a multi-label predictor which can assign a set of proper labels for unseen instance. To learn from PML training examples, the training procedure is prone to be misled by the false positive labels concealed in candidate label set. In light of this major difficulty, a novel two-stage PML approach is proposed which works by eliciting credible labels from the candidate label set for model induction. In this way, most false positive labels are expected to be excluded from the training procedure. Specifically, in the first stage, the labeling confidence of candidate label for each PML training example is estimated via iterative label propagation. In the second stage, by utilizing credible labels with high labeling confidence, multi-label predictor is induced via pairwise label ranking with virtual label splitting or maximum a posteriori (MAP) reasoning. Extensive experiments on synthetic as well as real-world data sets clearly validate the effectiveness of credible label elicitation in learning from PML examples.
Efficient Data Point Pruning for One-Class SVM
Authors: Fujiwara Yasuhiro , Kanai Sekitoshi , Arai Junya , Ida Yasutoshi , Ueda Naonori
Published: September 2019

One-class SVM is a popular method for one-class classification but it needs high computation cost. This paper proposes Quix as an efficient training algorithm for one-class SVM. It prunes unnecessary data points before applying the SVM solver by computing upper and lower bounds of a parameter that determines the hyper-plane. Since we can efficiently check optimality of the hyper-plane by using the bounds, it guarantees the identical classification results to the original approach. Experiments show that it is up to 6800 times faster than existing approaches without degrading optimality.
Bayesian Posterior Approximation via Greedy Particle Optimization
Authors: Futami Futoshi , Cui Zhenghang , Sato Issei , Sugiyama Masashi
Published: September 2019

In Bayesian inference, the posterior distributions are difficult to obtain analytically for complex models such as neural networks. Variational inference usually uses a parametric distribution for approximation, from which we can easily draw samples. Recently discrete approximation by particles has attracted attention because of its high expression ability. An example is Stein variational gradient descent (SVGD), which iteratively optimizes particles. Although SVGD has been shown to be computationally efficient empirically, its theoretical properties have not been clarified yet and no finite sample bound of the convergence rate is known. Another example is the Stein points (SP) method, which minimizes kernelized Stein discrepancy directly. Althoughafinitesampleboundisassuredtheoretically, SP is computationally inefficient empirically, especially in high-dimensional problems. In this paper, we propose a novel method named maximum mean discrepancy minimization by the Frank-Wolfe algorithm (MMD-FW), which minimizes MMD in a greedy way by the FW algorithm. Our method is computationally efficient empirically and we show that its finite sample convergence bound is in a linear order in finite dimensions.
Wasserstein Soft Label Propagation on Hypergraphs: Algorithm and Generalization Error Bounds
Authors: Gao Tingran , Asoodeh Shahab , Huang Yi , Evans James
Published: September 2019

Inspired by recent interests of developing machine learning and data mining algorithms on hypergraphs, we investigate in this paper the semi-supervised learning algorithm of propagating ”soft labels” (e.g. probability distributions, class membership scores) over hypergraphs, by means of optimal transportation. Borrowing insights from Wasserstein propagation on graphs [Solomon et al. 2014], we re-formulate the label propagation procedure as a message-passing algorithm, which renders itself naturally to a generalization applicable to hypergraphs through Wasserstein barycenters. Furthermore, in a PAC learning framework, we provide generalization error bounds for propagating one-dimensional distributions on graphs and hypergraphs using 2-Wasserstein distance, by establishing the algorithmic stability of the proposed semisupervised learning algorithm. These theoretical results also shed new lights upon deeper understandings of the Wasserstein propagation on graphs.
Eliminating Latent Discrimination: Train Then Mask
Authors: Ghili Soheil , Kazemi Ehsan , Karbasi Amin
Published: September 2019

How can we control for latent discrimination in predictive models? How can we provably remove it? Such questions are at the heart of algorithmic fairness and its impacts on society. In this paper, we define a new operational fairness criteria, inspired by the well-understood notion of omitted variable-bias in statistics and econometrics. Our notion of fairness effectively controls for sensitive features and provides diagnostics for deviations from fair decision making. We then establish analytical and algorithmic results about the existence of a fair classifier in the context of supervised learning. Our results readily imply a simple, but rather counter-intuitive, strategy for eliminating latent discrimination. In order to prevent other features proxying for sensitive features, we need to include sensitive features in the training phase, but exclude them in the test/evaluation phase while controlling for their effects. We evaluate the performance of our algorithm on several realworld datasets and show how fairness for these datasets can be improved with a very small loss in accuracy.
Hybrid Reinforcement Learning with Expert State Sequences
Authors: Guo Xiaoxiao , Chang Shiyu , Yu Mo , Tesauro Gerald , Campbell Murray
Published: September 2019

Existing imitation learning approaches often require that the complete demonstration data, including sequences of actions and states, are available. In this paper, we consider a more realistic and difficult scenario where a reinforcement learning agent only has access to the state sequences of an expert, while the expert actions are unobserved. We propose a novel tensor-based model to infer the unobserved actions of the expert state sequences. The policy of the agent is then optimized via a hybrid objective combining reinforcement learning and imitation learning. We evaluated our hybrid approach on an illustrative domain and Atari games. The empirical results show that (1) the agents are able to leverage state expert sequences to learn faster than pure reinforcement learning baselines, (2) our tensor-based action inference model is advantageous compared to standard deep neural networks in inferring expert actions, and (3) the hybrid policy optimization objective is robust against noise in expert state sequences.
Workup and Management of Immune-Mediated Colitis in Patients Treated with Immune Checkpoint Inhibitors
Authors: Singh Bhavana Pendurthi , Marshall John L. , He Aiwu Ruth
Published: September 2019

As the use of immune checkpoint inhibitors for several different malignancies becomes more mainstream, their side-effect profile raises new challenges. In 2011, the Food and Drug Administration approved the first checkpoint inhibitor for the treatment of advanced melanoma, and since then, checkpoint inhibitors have demonstrated efficacy in many other tumor types. Given the frequent use of immune checkpoint inhibitors in a wide range of cancers today, the diagnosis and management of their immune-mediated toxicities need special attention. One of the most common is immune-mediated colitis. Workup and management of immune-mediated colitis can be challenging and is the purpose of this review.

Key Points

Rate of immune mediated colitis differ from different kind of immune checkpoint inhibitor treatment. To work up immune-mediated colitis, tests to rule out infectious etiologies of diarrhea, colonoscopy and abdominal image will help to differentiate immune mediated colitis from colitis from other etiology. Patients with mild colitis can be managed with supportive therapies alone, but more severe cases may require immunomodulators such as steroid. Refractory cases may require tumor necrosis factor (TNF) inhibitors, such as infliximab in addition to steroid treatment.
A Phase I Study of Alpha-1,3-Galactosyltransferase-Expressing Allogeneic Renal Cell Carcinoma Immunotherapy in Patients with Refractory Metastatic Renal Cell Carcinoma
Authors: Hahn Andrew W. , Drake Charles , Denmeade Samuel R. , Zakharia Yousef , Maughan Benjamin L. , Kennedy Eugene , Link Charles , Vahanian Nicholas , Hammers Hans , Agarwal Neeraj
Published: September 2019

Lessons Learned

HyperAcute Renal immunotherapy was well tolerated and demonstrated antitumor activity in patients requiring salvage-line treatment for metastatic renal cell carcinoma (mRCC). HyperAcute Renal immunotherapy was safely administered with concomitant salvage-line treatments for mRCC, and it may be a candidate for inclusion in novel combinations for salvage treatment of mRCC because of its unique mechanism of action.

Background

HyperAcute Renal (HAR) immunotherapy exploits a naturally occurring barrier to xenotransplantation and zoonotic infections in humans to immunize patients against metastatic renal cell carcinoma (mRCC) cells. HAR consists of two allogeneic renal cancer cell lines genetically modified to express α(1,3)Gal, to which humans have an inherent pre-existing immunity.

Methods

Patients with refractory mRCC were eligible for this phase I dose-escalation trial. Concomitant treatment was permitted after the initial 2 months of HAR monotherapy. HAR was injected intradermally weekly for 4 weeks then biweekly for 20 weeks, totaling 14 immunizations. The primary endpoint was safety and determination of a maximum tolerated dose (MTD).

Results

Among 18 patients enrolled, two grade 3 adverse events (AEs) were attributed to HAR, lymphopenia and injection site reaction, and no grade 4/5 AEs occurred. The recommended phase II dose (RP2D) was 300 million cells. One patient had a partial response and eight patients had stable disease, for a disease control rate of 50% (9/18). Median overall survival with low-dose HAR was 14.2 months and was 25.3 months with high-dose HAR.

Conclusion

In pretreated mRCC, HAR immunotherapy was well tolerated and demonstrated antitumor activity. HAR immunotherapy may be a candidate for inclusion in novel combinations for salvage treatment of mRCC.
Thameslink programme, UK: collaboration at London Bridge station
Authors: Farrell Liam , Blanchflower Simon , Witcomb Tim
Published: September 2019

Completed in 2019, the Thameslink Programme was a £7 billion scheme sponsored by the UK government to transform north–south rail travel across London. One of the most challenging elements was redevelopment of London Bridge station. The number of interfaces, combined with the work’s scale and complexity, led to a new way of working with major suppliers. A collaborative partnership was formed, combining the skills, expertise and experience of all organisations into one effective delivery unit. Despite a challenging schedule, the partnership delivered against all its milestones and is recommended for similar complex projects.
Burden of CKD and Cardiovascular Disease on Life Expectancy and Health Service Utilization: a Cohort Study of Hong Kong Chinese Hypertensive Patients
Authors: Wan Eric Yuk Fai , Yu Esther Yee Tak , Chin Weng Yee , Fong Daniel Yee Tak , Choi Edmond Pui Hang , Tang Eric Ho Man , Lam Cindy Lo Kuen
Published: September 2019

Significance Statement

The relative effects of the burdens of CKD and cardiovascular disease on risk of mortality, direct medical costs, and life expectancy in people with hypertension are unknown. In this retrospective cohort study of 506,849 patients with hypertension in Hong Kong, co-occurrence of these conditions was associated with significant incrementally elevated mortality risk, direct medical costs, and reduced life expectancy. The authors found extremely high mortality risk and cost increases for severe CKD, exceeding the combined effects from heart disease and stroke. Moderate CKD, heart disease, and stroke had burdens that were similar individually and roughly multiplicative for any combination. These findings suggest that CKD prevention and intervention to reduce mortality and health care costs in people with hypertension should be given priority equal to that for cardiovascular disease.

Background

The relative effects of combinations of CKD, heart disease, and stroke on risk of mortality, direct medical costs, and life expectancy are unknown.

Methods

In a retrospective cohort study of 506,849 Chinese adults in Hong Kong with hypertension, we used Cox regressions to examine associations between all-cause mortality and combinations of moderate CKD (eGFR of 30–59 ml/min per 1.73 m2), severe CKD (eGFR of 15–29 ml/min per 1.73 m2), heart disease (coronary heart disease or heart failure), and stroke, and modeling to estimate annual public direct medical costs and life expectancy.

Results

Over a median follow-up of 5.8 years (2.73 million person-years), 55,666 deaths occurred. Having an increasing number of comorbidities was associated with incremental increases in mortality risk and medical costs and reductions in life expectancy. Compared with patients who had neither CKD nor cardiovascular disease, patients with one, two, or three conditions (heart disease, stroke, and moderate CKD) had relative risk of mortality increased by about 70%, 160%, and 290%, respectively; direct medical costs increased by about 70%, 160%, and 280%, respectively; and life expectancy at age 60 years decreased by about 5, 10, and 15 years, respectively. Burdens were higher with severe CKD.

Conclusions

This study demonstrated extremely high mortality risk and medical cost increases for severe CKD, exceeding the combined effects from heart disease and stroke. Mortality risks and costs for moderate CKD, heart disease, and stroke were similar individually and roughly multiplicative for any combination. These findings suggest that to reduce mortality and health care costs in patients with hypertension, CKD prevention and intervention merits priority equal to that of cardiovascular disease.
Öğretmen Adaylarının Dijital Okuryazarlık Düzeyleri
Authors: YONTAR Alper
Published: September 2019

Bu araştırmanın amacı, Sınıf Eğitimi ve Sosyal
Bilgiler Eğitimi programlarında okuyan öğretmen adaylarının dijital
okuryazarlık (sayısal yetkinlik) düzeylerini bazı değişkenler açısından
incelemektir. Çalışmada öğretmen adaylarının dijital okuryazarlık düzeylerini
ortaya koymak amacıyla tarama modeli kullanılmıştır. Araştırmaya, 2017-2018 eğitim-öğretim yılında, bir
devlet üniversitesinin, Sınıf Eğitimi ve Sosyal Bilgiler Eğitimi lisans
programlarının 3. ve 4. sınıflarına devam eden 216 öğretmen adayı katılmıştır. Örneklem
seçiminde, öğretmen adayları tarafından “Öğretim Teknolojileri ve Materyal
Tasarımı” dersini almış olma veya almakta olma şartı gözetilmiştir. Araştırma
verileri, Akkoyunlu, Yılmaz Soylu ve Çağlar (2010) tarafından geliştirilen
“Sayısal Yetkinlik Ölçeği” aracılığıyla toplanmıştır. Ölçek, 7’li likert tipi
45 maddelik bir ölçektir. Araştırmanın
veri toplama sürecinde araştırmacı, öğretmen adaylarına ölçekleri dağıtıp
gerekli açıklamaları yapmıştır. Toplanan verilerin analizinde SPSS 20 paket
programı aracılığıyla betimsel istatistiklerden ve t testi analizinden
yararlanılmıştır. Çalışmada ölçeğin motivasyon ve yetkinlik alt boyutlarını
oluşturan maddelerinden faydalanılmıştır. Bunun nedeni bu iki alt boyutun, bu
çalışmada ulaşılmak istenen verileri elde etmede yeterli olduğu düşüncesidir.
Dolayısıyla çalışmada ölçeğin iki alt boyutunu oluşturan toplam 26 maddesi
analize tabi tutulmuştur. Araştırma sonuçlarına göre erkek öğretmen adaylarının
dijital okuryazarlık düzeyleri, kadın öğretmen adaylarınınkinden anlamlı
derecede yüksek bulunmuştur. Katılımcıların genel olarak orta düzeyde dijital
okuryazarlığa sahip oldukları da çalışmanın bulguları arasındadır.