bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-wide epigenetic changes in compartments of genetically unbalanced human blastocysts
Authors: Tikhonov Andrei V. , Krapivin Mikhail I. , Malysheva Olga V. , Koltsova Alla S. , Komarova Evgeniia M. , Golubeva Arina V. , Efimova Olga A. , Pendina Anna A.
Published: September 2024

BACKGROUND: Epigenetic genome reprogramming is an important determinant of human embryo development. However, its mechanisms remain poorly elucidated, especially in genetically unbalanced embryos.
AIM: The aim of this study is the analysis of DNA methylation and hydroxymethylation levels in trophectoderm and inner cell mass of genetically balanced and unbalanced human blastocysts.
MATERIALS AND METHODS: Twenty-two IVF-derived human blastocysts were enrolled in the study; of these blastocysts, 15 were genetically unbalanced and 7 — genetically balanced. Detection of 5-methylcytosine and 5-hydroxymethylcytosine was performed on trophectoderm and inner cell mass nuclei by indirect immunofluorescence.
RESULTS: In genetically unbalanced blastocysts, the DNA methylation level was elevated in both compartments. The DNA hydroxymethylation level, in contrast, was elevated only in inner cell mass, whereas trophectoderm cells retained the same level as in genetically balanced embryos. These changes equalized the inner cell mass and trophectoderm DNA hydroxymethylation levels in genetically unbalanced blastocysts, while in genetically balanced ones the 5-hydroxymethylcytosine content in inner cell mass lagged behind that in trophectoderm.
CONCLUSIONS: Genetic imbalance is associated with differential epigenetic changes in trophectoderm and inner cell mass cells of human blastocysts: DNA methylation level increases in both compartments while DNA hydroxymethylation level increases only in inner cell mass. The trophectoderm cells in genetically unbalanced blastocysts retain the same hydroxymethylation level as in genetically balanced ones, suggesting a possible explanation of the ability of karyotypically abnormal embryos to implant.
Technical aspect of the operation of accelerometers as composition of a system for monitoring engineering structures of a cable-stayed bridge over the Petrovsky canal in the construction of the Western Speed Diameter highway in Saint Petersburg
Authors: Makhonko Andrey A. , Lazarev Yuri G. , Antonyuk Anatoly A.
Published: September 2024

Aim. This study analyzes the current monitoring system for the engineering structures of a cable-stayed bridge across the Petrovsky Canal, part of the Western High-Speed Diameter highway in St. Petersburg, focusing on emergency situations where accelerometers on pylons record values that exceed limits.
Methods and Materials. The study utilizes statistical data from existing monitoring system databases. The tasks, set within the framework of the study, are accomplished by applying theoretical scientific methods including analytical techniques, mathematical statistics, and induction.
Results. The analysis presents an overview of the current system used for monitoring engineering structures and highlights issues related to emergency situations in which accelerometer readings exceed threshold values. This study proposes a method for assessing the reliability of the monitoring system by classifying the data obtained from the accelerometer into two groups. The research identifies the need for further investigations to understand the root causes of these issues.
Conclusion. Тhe results can assist in the design and installation of monitoring systems of the engineering structures for cable-stayed bridges, as well as for modernization and optimization of existing monitoring systems to improve the quality of structural technical condition assessments.
Evaluation of the effectiveness of incomplete phase pulse width modulation algorithms in the converter-electric motor system
Authors: Saushev Alexander V. , Belousov Igor V. , Samoseyko Veniamin F.
Published: September 2024

Aim. This study evaluates the effectiveness of incomplete-phase algorithms for pulse width modulation of three-phase voltages in frequency control of electric drives, using integral current dispersion in the load as the criterion.
Materials and methods. This study examines pulse width modulation processes in frequency-controlled electric drives, focusing on the converter-electric motor system. Methods from electric circuit theory are used, with proposed algorithms illustrated through drawings, and these drawing can be implemented in the matrix laboratory software.
Results. The process of pulse width modulation in the converter-electric motor system is considered. It is demonstrated that to minimize the number of switching keys in the frequency converter, incomplete-phase pulse width modulation algorithms are beneficial. Expressions for local dispersion of the interphase current in single-phase and two-phase modulation are analyzed. An expression for local current dispersion in a three-phase bridge circuit load is derived, and the concept of integral current dispersion in a three-phase load is derived. Indicators for evaluating the effectiveness of algorithms for incomplete-phase pulse width modulation are proposed. Graphs the efficiency coefficient, characterizing incomplete-phase pulse width modulation with a minimum number of switching of key elements in the function of the amplitude coefficient and in the function of the relative frequency of modulation are constructed.
Conclusion. The results aid in developing algorithms for controlling frequency converters in asynchronous electric drive systems.
Analysis of culvert design methods as methods of ensuring reliability at the design stage
Authors: Tsybin Dmitry Yu. , Ermoshin Nikolay A.
Published: September 2024

This analysis focuses on the factors and methods for ensuring the reliability of metal culverts, which are essential for the trouble-free operation of motorways. Special attention is paid to the calculation methods for structures with annular cross-sections. The results of the work are conclusions about the necessity of their annular cross-section. They also conclude the importance of developing these structures to enhance culverts’ durability and failure-free operation. This involves considering the stochastic nature of load parameters, structural materials, and operating conditions. Addressing this issue is possible through the assessment of reliability indicators for culverts using simulation modeling methods.
Final test submission
Authors: Hossain Shahadat
Published: September 2024

This is final test submission.
AN ALGEBRAIC APPROACH FOR REFINED NEUTROSOPHIC RANDOM VARIABLES
Authors: Hatip Ahmed
Published: September 2024

In this article, we are going to extend the definition of literal neutrosophic random variables to literal refined neutrosophic random variables and we will study its new properties. We derive and present various concepts including refined neutrosophic probability distribution function in the continuous case, refined neutrosophic cumulative distribution function of continuous refined neutrosophic random variables, refined neutrosophic expected value, refined neutrosophic variance, refined neutrosophic standard deviation, refined neutrosophic mean deviation, refined neutrosophic rth quartiles, refined neutrosophic moments generating function, and refined neutrosophic characteristic function. Additionally, the paper includes many solved examples and applications. This paper opens the road to generalizing many concepts in neutrosophic probability theory specially neutrosophic reliability theory, neutrosophic stochastic processes, and neutrosophic queuing theory.
MXENE 2D Ti3C2TX PRODUCTION AND SPIN-ORBIT EFFECT (SOI) OF Ti3C2(OH)2 IN THE ELECTRONIC STRUCTURE
Authors: Ekici Mesut Ramazan , Uzunok Huseyin Yasin , Bulut Emrah , Tütüncü Hüseyin Murat , Atasoy Ahmet
Published: September 2024

Research on new-generation materials to meet the energy needs has begun to attract attention. Recetly, energy storage in materials has become the most researched area. As a result of the reaction of the MAX phase 312 Ti3SiC2 powder with hydrofluoric acid, a new 2D nanosized layered powder called MXene, similar to graphene, was obtained. MXenes, which have been studied in various sectors, especially energy, have attracted the attention of researchers owing to their multilayered structures. When Ti3SiC2 powder was treated with hydrofluoric acid (HF), an accordion-like two-dimensional Ti3C2Tx MXene structure was formed. In MXenes, surface coatings such as –O,–OH, and –F groups, which determine and affect various aspects of 2D materials, such as conductivity, constitute the application area. In this study, Ti3C2(OH)2–O and/or–OH surface terminations were examined using density functional theory (DFT) with the effect of the hydrofluoric acid etching time. Quantum Espresso program was used for DFT calculation. X-ray diffraction (XRD) and scanning electron microscopy (SEM and FESEM) were used to examine the MXene-phase Ti3C2Tx powder and first-principles calculations were performed. The structural and electronic properties of MAX and MXene compounds were determined. The spin-orbit effect (SOI) was examined in the electronic structure of MXene. The total and partial densities of states (DOS) with and without spin orbit were calculated
LAMBERT AZIMUTHAL EQUAL-AREA PROJECTION
Authors: Öztürk Emre
Published: September 2024

In the present study, we give the proofs about important properties of Lambert azimuthal projection, like conformality, preserve area e.g. which characterizes it. While there are some kind of Lambert projection for instance standard, cylindrical in the literature, we utilize from the south polar aspect and in our proofs, we use this approach. Finally, we give some visualizations of the inverse of projection as an example.
EFFICIENT DRUG CARRIER FOR ACETYLSALICYLIC ACID FROM CHITOSAN-BASED COMPOSITES PREPARED WITH MONTMORILLONITE, CELLULOSE AND HYDROXYAPATITE
Authors: Sezer Dilay , Aktaş Zeynep , Hoşgün Seda , Hoşgün Emir Zafer , Bozan Berrin
Published: September 2024

In this study, chitosan-based hydroxyapatite/chitosan (HAP/CHI), cellulose/chitosan (CEL/CHI) and montmorillonite/chitosan (MMT/CHI) composites were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Thermogravimetric Analysis (TGA). Acetylsalicylic acid (ASA) was used as a drug for loading and desorption studies to determine the release behavior of the synthesized composites. The maximum adsorption capacities (qe) were obtained as 251.5 mg/g, 197.7 mg/g and 288.95 mg/g for HAP/CHI, CEL/CHI and MMT/CHI, respectively. In vitro release studies of ASA from the composites HAP/CHI, CEL/CHI, and MMT/CHI were carried out phosphate buffer solution (PBS) and gastric juice (GJ). In the intestinal medium (PBS) controlled drug release continued for 72 hours (4320 minutes), and burst release was observed in the first 5 minutes in all composites. 19.16%, 47.15% and 37.32% of the active ingredient from HAP/CHI, CEL/CHI and MMT/CHI composites, respectively, were released in the first 5 minutes. After 5 minutes, the release slowed down and became more controlled for all three composites. At the end of the release, the highest releasing composite was CEL/CHI, with 95.77% ASA release. A total drug release of 87.48% was achieved with MMT/CHI and 87.37% with HAP/CHI. In the gastric environment (GJ) Controlled drug release continued for 72 hours (4320 minutes), and burst release was observed in the first 5 minutes in all composites. 52.51%, 72.30% and 44.87% of the active ingredient from HAP/CHI, CEL/CHI and MMT/CHI composites, respectively, were released in the first 5 minutes. After 5 minutes, the release slowed down and became more controlled for all three composites. At the end of the release, the highest releasing capacity was found with the CEL/CHI composite, with 96.05% ASA release. A total drug release of 93.26% was achieved with HAP/CHI and 84.89% with MMT/CHI.
GEOMETRIC PATTERN OF POWERS OF THREE VIA SIERPINSKI TRIANGULAR NUMBERS
Authors: Ermiş Temel
Published: September 2024

In this study, we describe a new number sequence based on integers arranged in a fractal like structure to visualize powers of three. Moreover, we associate these new numbers with triangular numbers
TRATAMIENTO DE AGUAS DE PRODUCCIÓN ASOCIADAS AL PETRÓLEO APLICANDO TÉCNICAS ELECTROQUÍMICAS CON IONES METÁLICOS DE MAGNESIO
Authors: García-Rodriguez Luis Eduardo , Marriaga-Cabrales Nilson de Jesús , Vargas-Florez Javier Hernando , Forero-Duarte Bernardo Enrique
Published: September 2024

En este estudio, se usó la electrocoagulación del arreglo de electrodos magnesio-magnesio como ánodo y cátodo en la técnica electroquímica para el tratamiento de aguas de producción asociadas a un campo de petróleo en Colombia. El uso del material del magnesio en los electrodos es una alternativa diferente a los materiales usados normalmente y aplicados en la industria del petróleo, como lo son el material de hierro y el aluminio. La electrocoagulación como técnica electroquímica es una tecnología limpia y emergente que ha sido aplicado desde el siglo XXI. El proceso de electrocoagulación y electrodosificación de iones de magnesio se realizó con cambio de polaridad con y sin ajuste de pH, aplicando una densidad de corriente de 1 mA/cm2 durante 25 minutos, encontrándose una disminución en la turbidez mayor al 80 %.
DNA Methylation and Its Application in IBD
Authors: Rezaei Arezou
Published: September 2024

The Article Abstract is not available.
A Simple and Rapid Colorimetric Method for Methanol Determination Using Sodium Nitroprusside
Authors: Bakhshi Ali , Savaee Mohamadreza , Goodarzvand Chegini Koorosh , Hedayati Mehdi
Published: September 2024

Introduction: Methanol (CH3OH) exposure can be highly toxic to humans, resulting in severe clinical manifestations and even deaths if left untreated. Therefore, it is vital to estimate the amounts of methanol quickly and accurately to avoid its adverse health impacts. The main goal of the current study was to develop a simple, fast, reliable, and cost-effective colorimetric method for determining methanol amounts in some alcoholic and non-alcoholic samples.
Materials and Methods: A sodium nitroprusside-based colorimetric method was established to detect methanol in hand sanitizers, alcoholic beverages, and herbal distillations. A gas chromatography-mass spectrometry apparatus was applied to evaluate the efficacy of the Kit.
Results: The naked eye saw the color change in the presence of methanol. The established method revealed a good sensitivity (0.077%) and accuracy for methanol determination in different samples. Besides, this colorimetric method was precise, with intra- and inter-assay coefficients of variations less than 10%. Notably, the recovery percentages were 96.5% to 108%, indicating the acceptable accuracy of the studied method. The quantitative detection of methanol was finally validated by comparing it with gas chromatography-mass spectrometry results.
Conclusions: This colorimetric method has great potential for methanol detection due to advantages such as good sensitivity, acceptable accuracy, and fast response time.
The Oncogenic Potential of IQ Motif-Containing GTPase-Activating Protein3 in Human Bladder Cancer: An In-Silico Analysis
Authors: Abazari Omid , Vahidi Serajoddin , Modarressi Mohammad Hossein , Reza Javad Zavar
Published: September 2024

Introduction: IQ motif-containing GTPase-activating protein3 (IQGAP3) contributes to the progression of bladder urothelial carcinoma (BLCA), but its mechanisms are not systematically specified. Due to the oncogenic potential of IQGAP3, the current in-silico study intended to elucidate IQGAP3's role in BLCA progression.
Materials and Methods: Many bioinformatics tools, including UALCAN, Kaplan–Meier plotter, TNMplot, cBioPortal, GeneMania, Enrichr, TIMER2, muTarget, and UCSC Xena, were applied in the current study.
Results: The IQGAP3 level was more pronouncedly raised in BLCA tissues than in normal bladder tissues, and its increased expression was related to the advanced stage and higher grade. Enhanced IQGAP3 expression could result from its genetic alteration. Moreover, the mutation in P53 and RB1 genes was robustly associated with increased IQGAP3 expression. Besides, IQGAP3 correlative genes were dominantly involved in the cell cycle. On the other hand, IQGAP3 upregulation influenced immune checkpoint levels in the tumor microenvironment.
Conclusion: The in-silico findings suggested that IQGAP3 overexpression could be a crucial biomarker in BLCA.
Attitudes and Levels of Concern and Trust Towards COVID-19 Vaccination Among Patients Hospitalized at Shahid Beheshti Hospital in Kashan, Iran
Authors: Momen–Heravi Mansooreh , Arabzadeh Mohammad Ali , Fathizadeh Hadis , Farrahi Razieh
Published: September 2024

Introduction: This study aimed to explore hospitalized patients' attitudes, concerns, and trust regarding Coronavirus disease 2019 vaccination.
Materials and Methods: This descriptive-cross-sectional study was conducted on 128 patients hospitalized at Shahid Beheshti Hospital in Kashan, Iran, in 2022. Participants were selected using simple random sampling. The questionnaire included questions about demographic information, attitudes towards vaccination (7 items), levels of concern (14 items), and trust (15 items). Data were analyzed using SPSS 26 software. Descriptive statistical analysis and chi-square tests applied.
Results: Fifty-three (41.4%) of cases had a history of two vaccinations. Sinopharm was used in 28.12% of patients. The average attitude score was 8.21 ± 2.88, significantly associated with age (p = 0.02), nationality (p = 0.01), education (p = 0.01), and vaccination history (p = 0.02). The mean concern score was 35.41 ± 11.87, significantly linked to gender (p = 0.01) and vaccination history (p = 0.02). The average trust score was 40.50 ± 13.64, significantly associated with age (p = 0.04), gender (p = 0.01), vaccination history (p = 0.01), hospitalization history due to COVID-19 (p = 0.03), and COVID-19 infection history (p = 0.03).
Conclusion: The vaccination rate among participants was acceptable. However, concerns about vaccination and its complications were the primary reasons for vaccine hesitancy. Given that vaccine acceptance across various community groups is as crucial as vaccine development, it is recommended that health organizations provide information on vaccine benefits and address concerns about potential side effects.
Significant Impact of let-7d MicroRNA on Breast Cancer Cell Lines Post-Radiation Treatment
Authors: Nejadtaghi Mahdieh , Mozdarani Hossein
Published: September 2024

Introduction: Radiotherapy is a common treatment for breast cancer treatment, that induces DNA damage. These DNA damages are addressed through various repair pathways, which regulate the DNA repair systems and confer radio-resistance. Non-coding RNAs are a big proportion of genome transcripts without the potential to encode proteins. Related studies demonstrated that radiation affects the expression of non-coding RNAs. Let-7d, a tumor suppressor in numerous cancers, has some target genes that play a role in the DNA repair system.
Materials and Methods: Human breast cancer cell lines MDA-MB-231 and MCF-7 were cultured in a Dulbecco's Modified Eagle Medium. The exponentially growing cells were treated with some doses of X-rays. After radiation treatment and cell harvesting, RNA was extracted, and cDNA synthesis was done. The let-7d miRNA expression changes were calculated with real-time quantitative reverse transcription polymerase chain reaction.
Results: The results implied that radiation caused increased let-7d expression in breast cancer cell lines after radiation treatment. In addition, the results showed that 24 h after radiation, the expression of let-7d in the radioresistant cell line was higher than the radiosensitive one; 48 h after radiation, the expression of let-7d in the radiosensitive cell line was higher than the other one.
Conclusions: The results demonstrated that radiation treatment increased let-7d miRNA expression in both radiosensitive and radio-resistant breast cancer cell lines. Therefore, let-7d might be involved in the radiosensitivity of breast cancer.
Evaluating the Effects of Ketamine on Serum Glutamate Dehydrogenase, Glutamine Synthetase and Asparagine Synthetase Levels in Patients with Major Depressive Disorder Before and After Ketamine Treatment
Authors: Tary Eisa Taheri , Qujeq Durdi , Kheirkhah Farzan , Hajian-tilaki Karimollah
Published: September 2024

Introduction: It has been revealed that major depressive disorder (MDD)is a common and debilitating psychiatric disorder. Dysfunctional enzymes involved in neurotransmission glutamate dehydrogenase (GDH), Glutamine synthetase (GS) and Asparagine synthetase (ASNS) may underlie the pathophysiology of MDD. The present project aimed to explore the effects of Ketamine on GDH, GS and ASNS in MDD patients. This study provides evidence of interactions between ketamine and GDH, ASNS and GS levels in patients with MDD.
Materials and Methods: Patients with MDD are referred to the psychiatric ward of Shaheed Yahyanejad Hospital for regular follow-up. Patients diagnosed with MDD were based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), structured clinical interviews, as well as the severity of depression based on clinical criteria determined by a specialist physician. Serum samples from MDD patients before and after ketamine administration were taken to examine the changes in GDH, ASNS and GS levels. In this project, 29 patients with MDD therapy were evaluated with ketamine (0.75 mg/kg).
Results: Our study showed that after administrating ketamine, the level of ASNS and Glutamate dehydrogenase GDH in patients with MDD was reduced compared to pre-treatment. However, the level of GS was increased compared to before treatment. The results show that ketamine occurs at the metabolism level in MDD patients. Also, our results demonstrated that GDH, ASNS, and GS levels can be measured to evaluate the effect of Ketamine on MDD patients.
Conclusions: Patient success has improved depression after two months of administrating ketamine. Marginally, more than 80% of patients diagnosed with MDD treated with ketamine showed complete remission. Current results may be helpful in understanding the mechanisms responsible for ketamine’s clinical efficacy.
Investigating the Association between Coping Styles and Social Identity in Adolescents of Marginal and Non-Marginal Areas
Authors: Mosafer Hadis , Khaledi-Paveh Behnam , Salari Nader , Rahmati Mahmoud
Published: September 2024

Objective: This study aimed to investigate the relationship between coping styles and social identity among adolescents residing in marginal and non-marginal areas.
Method: A cross-sectional study design with a descriptive-analytic approach was utilized. The study population consisted of adolescents aged 12 to 19 from Kermanshah city, with 222 participants evenly distributed between marginal and non-marginal areas. Adolescents were enrolled in the study using a multi-stage sampling method (stratified cluster, simple randomized method). Data were collected using the Standard Social Identity questionnaire and Lazarus and Folkman's Coping Styles questionnaire. The data were analyzed statistically in the SPSS software environment (version 25) using appropriate statistical tests.
Results: The results of the study showed that there is a significant relationship between the components of social identity and coping styles in adolescents (P < 0.05). Emotion-focused and problem-focused coping styles had the ability to explain social identity in the adolescents of Kermanshah city. Also, in comparing the coping styles and social identity between adolescents from marginalized and non-marginalized areas in the city of Kermanshah, there was no significant difference (P < 0.05).
Conclusion: This study underscores the importance of understanding how coping strategies influence social identity among adolescents across different socio-environmental contexts. The findings highlight the need for further research to explore the mechanisms underlying these relationships and consider the role of contextual factors in shaping adolescent development.
Validity Study of an Emotional Face-Database in Iranian Community
Authors: Mohammadzadeh Azar , Tehrani-Doost Mehdi , Yaghoobi Elnaz
Published: September 2024

Objective: To investigate the accuracy of facial emotion recognition in the Iranian community, a face database validated in this community is required. To do this, we conducted a validation study on the Radboud face database. The primary objective of this study was to evaluate the accuracy of recognizing emotions through faces in an Iranian sample and then to choose the pictures with high agreement in terms of detecting emotions.
Method: This is a cross sectional study recruiting a total number of 142 males and females aged between 20 and 50 years old (Mean ± SD of age 31.7 ± 7.07). The participants were instructed to detect the type of emotion of each face as well as its valence and arousal. The percentage of participants’ agreement on evaluating each picture was assessed. To evaluate the effect of different variables on participants’ accuracy, one way and repeated measure ANOVA analyses were also used.
Results: Emotional faces were recognized by around 84% of the participants. The highest accuracy belongs to happy (Mean ± SD of 98 ± 6.1%) and the lowest one to neutral (75 ± 18.06%) faces. The accuracy for detecting other emotions were as follows: sad (91 ± 8.7%), surprised (87 ± 10.64%), angry (77 ± 15.6%), and fearful (76 ± 15.26%). Additionally, we found no differences between male and female participants in terms of recognizing emotions. Then we selected the pictures with high agreement (above 85 percent) in labeling emotions among the participants.
Conclusion: The current study provided a valid emotional face database based on Iranian participants’ responses in terms of recognizing basic emotions. The selected pictures can be used in designing tasks to evaluate emotion recognition ability in clinical and nonclinical populations. It can also be used in designing applications to improve detecting emotion in clinical samples such as individuals with autism spectrum disorder.
The Psychometric Properties of the Persian Version of Emotional Abuse Questionnaire
Authors: Shafiei Rezvani Nejad Kosar , Mirpour Zinat Sadat , Novin Mohammad Hassan , Chenari Anita Najafi , Jafaryparvar Zakiyeh
Published: September 2024

Objective: Intimate partner emotional abuse is a serious issue that can lead to catastrophic outcomes for victims. Emotional abuse involves psychological tactics to control, manipulate, and degrade a person within an intimate relationship. This research aimed to translate the Emotional Abuse Questionnaire (EAQ) developed by Jacobson and Gottman into Persian for use among Iranian university students.
Method: The translation of the 66-item EAQ involved a meticulous forward and backward translation process, linguistic matching, and a pilot review. In this cross-sectional study, 346 university students from Rasht, Iran, completed the EAQ. The mean age of participants was 26.78 ± 8.10 years, with most being female (89.0%). Reliability was evaluated using Cronbach's alpha and test-retest analysis while content and face validity were assessed by a panel of experts. Construct validity was examined through confirmatory factor analysis (CFA) and internal consistency measures. Divergent validity was assessed by comparing the EAQ with the ENRICH Marital Satisfaction Scale (EMS).
Results: Impact scores for face validity ranged from 2.33 to 3.92, based on respondents' ratings of frequency and importance. Content validity assessment led to removing four items with a CVR below 0.62, resulting in 62 valid items. The EAQ showed strong internal consistency, with a Cronbach’s alpha of 0.97, exceeding the acceptable threshold of 0.70. CFA results confirmed the validity of the second-order factor model of the EAQ (χ2/df = 4.34, CFI = 0.95, RMSEA = 0.098, SRMR = 0.077). The EAQ demonstrated a strong correlation with EMS measures, confirming divergent validity.
Conclusion: The Persian version of the EAQ is a reliable instrument for assessing emotional abuse among Iranian university students. Future research should explore the cultural sensitivity of the questionnaire and investigate associations between emotional abuse and other variables of interest, such as mental health outcomes or relationship dynamics. These avenues promise valuable insights into the frequency and effects of emotional abuse across diverse cultural contexts.
Predictors of Attitudes toward Aging in Middle-Aged Individuals: A Cross-Sectional Study
Authors: Mohamadzadeh Marzieh , Zanjari Nasibeh , Aliakbarzadeh Arani Zahra , Shoraka Hamidreza , Pirouzeh Razieh
Published: September 2024

Objective: Attitudes toward aging (ATA) are among the most important determinants of well-being in old age. However, little research has examined factors contributing to their formation in middle-aged individuals. This study aimed to investigate predictors of attitudes toward aging among Iranian middle-aged individuals in 2022.
Method: This study recruited 330 people with a mean age of 56.5 ± 5.6 using multistage cluster sampling. Data were collected using a three-part questionnaire, including demographic factors, an attitude toward aging questionnaire (AAQ), and a multidimensional scale of perceived social support (MSPSS). The obtained data were analyzed using SPSS (v.22) statistical software to conduct t-tests, ANOVA, Pearson correlation, and linear regression.
Results: According to bivariate analysis, perceived social support (PSS), age, level of education, and perceived income adequacy (PIA) had a significant relation with the total ATA score (P < 0.05). According to regression analysis, family support (β = 0.288, P < 0.001), friend support (β = 0.188, P < 0.001), significant others support (β = 0.130, P = 0.04), age (β = 0.118, P = 0.002), and PIA (β = 0.290, P < 0.001) were the predictor factors of ATA and explained 41% of the variance. PSS and PIA were the predictors of all dimensions of ATA.
Conclusion: The results highlight the role of potentially modifiable factors, such as PSS, PIA, and level of education, in shaping ATA. This requires interventions and policies that effectively promote social and financial support in middle-aged individuals.
Investigating the Relationship between Schizophrenia and Incidence Risk of Breast Cancer: A Systematic Review and Meta-Analysis of Cohort Studies
Authors: Mahdi Mahdavinoor Seyyed Muhammad , Soleimanabad Saeed Kargar , Bordbari Amir-Hassan , Mollaei Aghil , Seddigh Leila , Sarihi Sorour , FirooziKhojastefar Reihaneh , Dehbozorgi Raziye , Farhang Sara
Published: September 2024

Objective: Schizophrenia seems to have a complex association with various types of cancer, exerting a protective effect against some cancers while being a risk factor against some others. Therefore, we intended to conduct an updated systematic review and meta-analysis in order to examine the relationship between schizophrenia and the risk of breast cancer incidence.
Method: We did a systematic search of databases, namely Web of Science, Scopus, Embase, PubMed, and PsycINFO up to August 15, 2024. Screening and data extraction were performed independently. Data was analyzed using Stata16 software. We used the random effect model to pool the results, while the heterogeneity between studies was calculated using Cochran's Q test and (I2) index.
Results: We found 15 studies, among which 12 were included in this meta-analysis. The results indicated that the risk of breast cancer development is significantly increased in women with schizophrenia (SIR: 1.43, 95% CI: 1.08-1.85, P < 0.01; IRR: 1.19, 95% CI: 1.13-1.26, P < 0.01). Subgroup analysis revealed significant differences in the incidence of breast cancer rates among women with schizophrenia based on geographic location and duration of follow-up.
Conclusion: The results indicate that schizophrenia increases the risk of developing breast cancer. Therefore, taking preventive measures concerning breast cancer among women with schizophrenia is crucial. Additionally, regular screening programs should be implemented to ensure early diagnosis and treatment in case breast cancer is detected.
A Theory on the Nonlinear Relationship of Sexual Behavior and Aggression
Authors: Marashi Sayed Ali
Published: September 2024

Objective: Claims have been made that more sexual liberalism in society than what generally existed in human history is necessary to promote societal tranquility and reduce violence. This research was conducted to investigate the real relationship between sexual behavior and aggression based on scientific data especially from the perspective of physiological psychology.
Method: This study was a narrative review and utilized evidence-based findings from neuropsychology, psychophysiology, laboratory research, and field studies. Databases were explored for related terms until sufficiency was reached. The findings were categorized and analyzed descriptively and interpretively to establish connections between the findings. Ultimately, a comprehensive conceptualization was developed to conclude a theory on the relationship between sexual behavior, sexual satiety, and aggression.
Results: The study indicated that unrestrained sexual behavior leads to an escalation of the behavior, rather than satiation, and aggression rather than calmness. This may be due to positive feedback in the nervous and hormonal systems, specifically mediated by the medial preoptic area (MPA) and testosterone, leading to aggressive behavior. However, since sexual deprivation can potentially lead to aggression, it is advisable to view the relationship between sexual activity and violence as a non-linear one.
Conclusion: This paper establishes that the intensification of sexual behaviors leads to increased violence and aggression in society, ultimately elevating levels of public insecurity. Therefore, limiting sexual behavior within the framework of the relationship of married couples may serve as a moderating factor for this phenomenon.
Evaluation of Prescription Patterns in Management of Agitation in Patients Referred to the Emergency Department
Authors: Abshari Atefeh , Mohebbi Niayesh , Mohammadjafari Atefeh
Published: September 2024

Objective: This research aims to evaluate patterns of prescription of medications used to manage acute agitation in adult Iranian patients at the emergency department (ED) of Roozbeh Psychiatric Hospital in Tehran.
Method: The study analyzed data from the medical records of 252 patients who received pharmacotherapy for agitation.
Results: The findings revealed that 181 patients (71.82%) were given typical antipsychotics, with haloperidol being the most commonly prescribed medication. Atypical antipsychotics were administered to 24 participants (9.52%), primarily olanzapine, and 52 patients (20.63%) received benzodiazepines, predominantly lorazepam. The treatment response was also assessed as appropriate in 224 patients (88.89%) and inappropriate in 28 patients (11.11%).
Conclusion: The study recommends providing new-generation medications to developing countries and underscores the importance of updating student educational programs.
Using Nanozymes in the Removal of Persistent Organic Pollutants from Water Environments
Authors: Pormazar Seyedeh Mahtab
Published: September 2024

The Article Abstract is not available.
Health Risk Assessment of Nitrate, Nitrite, and Fluoride Ions in Water Reservoirs of Mehriz, Iran in 2023
Authors: Ghasemzadeh Ali , Taghi Ghaneian Mohammad , Fallahzadeh Reza Ali , Nodoshan Vahid Jafari , Fallahzadeh Hossein , Dalvand Arash
Published: September 2024

Introduction: High concentrations of nitrate, nitrite, and fluoride in drinking water can cause adverse health effects. This study aims to investigate concentration and health risks assessment of nitrate, nitrite, and fluoride ions in water reservoirs of Mehriz city and Bahadoran district.
Materials and Methods: Monthly sampling was done from water reservoirs of Mehriz city and Bahadoran district for 6 months. Nitrate, nitrite, and fluoride concentrations were measured in the samples using a spectrophotometer. Then, health risk assessment and sensitivity analysis were performed on the obtained data using Crystal Ball software and Monte Carlo simulation method.
Results: Nitrate, nitrite, and fluoride concentrations were lower than the standard limitation in all of the studied areas. Risk assessment findings indicated that hazard quotient (HQ) values of nitrite in Miankoh-Movahedin, Bidok and Bahadoran water reservoirs were less than 1 for all age groups. HQ values of nitrate were also below 1 for all age groups except children. HQ values of fluoride in Bahadoran water reservoir were below 1 for all age groups except children.
Conclusion: Health risk of consuming water containing nitrates and fluorides is high for children. Based on sensitivity analysis, the concentration of nitrate and fluoride in drinking water is the key factor in raising health risks. Reducing nitrate and fluoride concentrations in drinking water can reduce health risks in the population.
Evaluating the Efficiency of Aerated Lagoon System regarding the Removal of Indicator Bacteria from Municipal Wastewater
Authors: Salar Sara , Eftekhari Fatimah , Shafipour Maryam , Ebrahimnia Reza , Moghadar Ebrahim , Moosavi Seyed Abedin , Safari Hassan , Seyedghasemi Navisa Sadat , Shahryari Ali
Published: September 2024

Introduction: Treatment of municipal wastewater is essential to remove bacteria. This study is designed to evaluate the efficacy of a wastewater treatment plant (WWTP) for the removal of bacteria and using for irrigation or discharge in the Caspian Sea according to the World Health Organization (WHO) regulations.
Materials and Methods: A total of 105 samples were collected from 7 stations, including the inlet and the outlet of the WWTP in Bandargaz City (Iran), the intersection point of wastewater effluent with Caspian Sea (Gorgan Bay), and a radius of 200 meters in three directions east, west, and north of the intersection point of wastewater in Gorgan Bay. The multiple-tube fermentation technique was used to enumerate bacteria, and results were expressed as the Most Probable Number (MPN) per 100 ml.
Results: Bacteriological analysis exhibited that the concentration of total coliform, fecal coliform, fecal streptococci, and Clostridium perfringens were 1.38×1010, 5.57 × 107, 5.53 × 109, 1.26 × 109 in inlet, and 1.38 × 1010 , 5.57 × 107, 5.53 × 109 , 1.26 × 109 in outlet of WWTP, respectively.
Conclusion: The aeration lagoon has a low performance in bacteria population removal, which may be due to the climate condition of this region (few sunny days and many cloudy and rainy days). This effluent was not generally acceptable for discharge in the environment and reuse. Therefore, it is essential to modify the disinfection process to keep the concentration of bacteria under control. Additionally, continuous monitoring is necessary to control the quality of wastewater  before discharge into the environment or reuse
Promoting Women's Health by Managing Health Resources: A Letter to Editor
Authors: Khosravi Shahla , Rad Mahsa Khoshnam , Setayesh Valipour Nasimeh
Published: September 2024

Advancing the health goals of society requires human resources management of health as one of the most important tools. Providing the opportunity according to the skill and knowledge of service providers is the basis for providing quality services while considering the cost. This article explains the position of reproductive health scholars as a group to advance the health goals of mothers and babies.
Investigating of Resilience Scale of Selected Hospitals in Yazd City during Disaster Conditions in 2023
Authors: Akhoondi Haniye , Ameryoun Amirali , Najafi Rasoul , Askari Rohollah
Published: September 2024

Background: The need for healthcare is one of the fundamental needs of humans in critical and emergency situations. Hospitals and healthcare centers are among the first units that can reduce casualties by providing optimal and timely healthcare services. Therefore, the present study aims to evaluate the resilience status of selected hospitals in Yazd city during the crisis in the year 2023.
Methods: This research is a descriptive-cross sectional study conducted in 2023 in 5 selected hospitals in Yazd (classified by hospital ownership: university hospitals A, B, C, charity hospital D, and private hospital E). The resilience level of the hospitals during a crisis was assessed using Zhong's standard questionnaire, which evaluated 9 dimensions of resilience. Responses to the questions were based on a 5-point Likert scale (always to never), and data were analyzed using SPSS 26 software. Quantitative data were reported with central (mean) and dispersion (standard deviation) indicators, followed by qualitative (demographic) data as numbers and percentages.
Results: The results showed that the overall resilience status of the hospitals in this study averaged 3.95 ± 0.69, which was evaluated at a good level. The highest score was for the private hospital E with an average of 4.30 ± 0.55, and the lowest score was for the public hospital A with an average of 3.75 ± 0.55. Hospital A's score was at a moderate level, while the remaining hospitals were rated at a good level.
Conclusion: Considering the average resilience of hospitals in a number of areas, it is suggested to develop and present training programs related to preparing for critical situations and holding maneuvers and conducting exercises with emphasis on training key employees.
Effectiveness of Joint Attention Training on Basic Social Communication, Anxiety and Executive Functions of Children with Autism Spectrum
Authors: Mahmmoudiany Sardasht Birivan , Ehtshamzadeh Parvin , Hafezi Fariba
Published: September 2024

Introduction: The aim of this study was to investigate the effectiveness of joint attention training on basic social communication, anxiety and executive functions of children with autism.
Methods: The research design was quasi-experimental and pre-test and post-test with control group. The statistical populations of children with autism spectrum were referred to the psychiatric and psychological centers in Urmia City during the year 2021-2022. 30 individuals (15 ones from the shared attention group and 15 from the control group) were selected as a statistical sample using the available and targeted method. Data via questionnaires of basic social communication (Zabov, 2010), anxiety (Spence, 1999), executive functions of the parents' brief form (Balster Gerard et al., 2000) were collected during the intervention therapy method of joint attention training (Vakilizad and Abedi, 2015) (12 sessions, 3 days a week, each session was an hour and a half, each session was divided into 3 parts of 25 minutes with a 5 minute break for the child). Then the data were analyzed with Software SPSS V. 16 and multivariate analysis of covariance test.
Results: The results showed that joint attention training increased basic social communication and executive functions and reduced anxiety in children with autism spectrum. The differences between the investigated groups and the conducted tests were significant (P≤0.01).
Conclusion: Interventional treatment methods such as joint attention training should be developed for the treatment of autistic patients, so that with the help of these methods, the individual and collective life of these patients can be improved.
Effect of Hydralcoholic Extract of Dafneh on Expressin Level of MAPK8 and PTK2 Genes and Cell Viability of Ovarian Cancercell Lines (A2870S)
Authors: Bafrouizadeh Faezeh , Sabbagh Seyed Kazem , Mazaheri Mahta , Sarafraz-ardakani Mohammad Reza , Shetabi Farzaneh
Published: September 2024

Introduction: Ovarian cancer, as an aggressive epithelial tumor, remains one of the leading causes of cancer-related mortality in women. Regarding to the side effects of chemical drugs, medicinal plants, according to their unique properties such as cheapness, naturalness and availability, and without any significant side effects, medicinal plants have recently been considered in the prevention of diseases. In this laboratory research, the cytotoxic effect of hydroalkolic extract of Daphne mucronata Royle on cell viability of A2780 cancer cell and the expression of MAPK8 and PTK2 genes in the cells treated with the Ephedra plant extract during three-time interval 24,48 and 72 hours after treatment were investigated.
Methods: The inhibitory effect of hydroalcholic extact of D. mucronato on targeted cells was done using MTTassay then, expression level of MAPK8 and PTK2 genes in cells treated with plant extract were investigated using qRT-PCR method. Data analyses were done using GraphPad prism software.
Results: Regarding to the results of cell viability, IC50 rate for 24, 48 and 72h after treatment were determined as 105.40, 85.98 and 81.38µg/mL, respectively. Expression analysis of tested genes showed that hydroalcoholic plant extract of D. mucronato had not significant effect on expression of targeted genes (Pvalue≤0.05) so that there was no significant difference on their expression level compared to the control.
Conclusion: According to the results, it can be concluded that D. mucronato extract had a significant inhibitory effect on treated A2870s cancer cells, but it was not able to change the expression level of genes involved in anticancer activities and its molecular pathways. The use of bio-markers and other gene pathways is suggested for additional studies.
Unveiling Antiarthritic Potential of Moringa oleifera Lam. Extract: Evaluation and Hydroxypropylmethylcellulose-Based Formulation
Authors: Pandey Minakshi , Bajpai Meenakshi
Published: September 2024

Medicinal plants consist of complex chemical compounds that have been acknowledged for their important role in treating persistent human illnesses. This research concentrates on the phyto-physicochemical evaluation of Moringa oleifera Lam. extract and its in vitro anti-arthritic properties, as determined by inhibiting protein denaturation utilizing varying concentrations of the extract and a standard drug, diclofenac sodium. The study's results revealed a significant in vitro anti-arthritic impact of the extract, with an 85.8% inhibition compared to the standard drug's 99.9% inhibition. Furthermore, this research involved creating sustained-release tablets using hydroxypropyl methylcellulose (HPMC)-based formulations and various grades of hydrophilic polymers along with a fixed quantity of a hydrophobic polymer. The manufactured tablets demonstrated favourable sustained-release traits through direct compression, with the MF2 formulation showing a 73.8% cumulative release over 10 hours.