bluuebunny/crossref_metadata_2025 huggingface dataset:
Ahorro, planes de pensiones y déficit público
Authors:   Universidad de Valencia, Quesada Javier
Published: February 2025

Este artículo analiza el efecto del incentivo fiscal al ahorro privado que disfrutan los planes privados de pensiones sobre el ahorro total nacional. Se presenta, mediante un ejercicio de simulación calibrado para el caso español, el efecto global sobre el déficit público. En general se observa que un incentivo al ahorro privado tiene un efecto inicial depresivo sobre el ahorro público que desaparece tan pronto las rentas procedentes del incremento de stock de capital que tiene lugar en la economía comienza a mejorar los ingresos públicos a través del impuesto sobre sociedades.
Aproximación a las cuentas financieras de la economía vasca 1985-1991
Authors:   Gobierno Vasco, Alberdi Larizgoitia Alberto , Barrena Longarte Leyre ,   Gobierno Vasco, Olalde Maguregui Arantza ,   Gobierno Vasco
Published: February 2025

Como es sabido, las cuentas financieras muestran el ahorro financiero de los diferentes agentes institucionales de la economía y las operaciones a través de las que se materializa dicho ahorro. Además suponen una valiosa contribución a la investigación de la relación entre el mundo real y el financiero ya que para el conjunto de la economía el ahorro financiero neto equivale al exceso de ahorro nacional disponible sobre, la formación bruta de capital. En este trabajo se presenta un primer resultado de las cuentas financieras de la economía vasca para el periodo 1985-1991, expresadas tanto en términos de saldos como de flujos. El apartado introductorio enmarca el estudio a nivel teórico e incluye una valoración global del trabajo. A continuación se ofrece una descripción detallada de la metodología utilizada, para finalizar con una presentación de los resultados obtenidos por grandes sectores institucíonales e instrumentos.
Sekularisasi: Salah Satu Ancaman bagi Kehidupan Beragama di Indonesia
Authors: Suwandi Zahrany Aulia
Published: February 2025

Secularization is defined as the process of separation between religion and state, where religion no longer has a central role in public and political life. Many people say that religion is an addiction and is very restrictive in worldly life so that it must be separated from public and political life. This article aims to conclude that secularization is a complex phenomenon with various impacts on religious life in Indonesia. This study uses qualitative research with a literature study approach. The results of the study suggest that secularization can be a threat to religious life in Indonesia for several reasons. Secularism must be seen as a constructive criticism for Indonesia. Secularism can cause moral decline, but it also encourages reflection and strengthens Pancasila as the foundation of the state. The research method used in this study uses literature studies, namely by searching for and analyzing data and sources of information related to secularism. The formulation of the problem of this study, the researcher discusses the process of secularization in Indonesia, the threat of secularization to religious life in Indonesia, and how religious people in Indonesia respond to this issue. As a result, religious communities in Indonesia need to understand secularization well and respond to it wisely in order to maintain a healthy and tolerant religious life.
O desfecho clínico do paciente pós prostatectomia radical na perspectiva da reabilitação peniana
Authors: Júnior Henrique Assis de Oliveira , Orsolin Cristiano Renato , Silva Matheus Figueiredo , Toledo José Henrique Gonçalves de , Maia Aluizio Del Bianco , Santos Raphael Henrique dos
Published: February 2025

O câncer de próstata é uma das neoplasias mais clássicas na população masculina. A prostatectomia radical está entre os principais desfechos para esse ocorrido, sendo a primeira escolha mediante enfermidades localizadas e localmente avançadas. No entanto, essa modalidade de tratamento cirúrgico costuma trazer grande prejuízo à função sexual masculina de modo amplo. Estima-se que a disfunção erétil é uma implicação frequente e temida do tratamento cirúrgico do câncer de próstata, de forma que há diversas estratégias para prevenir e tratar tal condição. Porém, uma adequada reabilitação sexual desses pacientes envolve um atendimento global às dificuldades encontradas na recuperação de uma vida sexual satisfatória, não apenas focado na qualidade das ereções. Atualmente, existem inúmeros transtornos sexuais frequentes que são desencadeados pela prostatectomia radical, mas que ainda são extremamente negligenciados no cuidado pós-operatório. Dentre eles, existem a necessidade de reabilitação peniana.
Estrés por Tecnologías: Estrategias de Afrontamiento de Docentes en Áreas Rurales
Authors: Bravo-Zurita Valeria Emperatriz
Published: February 2025

Justificación: a medida que los docentes enfrentan nuevas exigencias relacionadas con el uso de herramientas digitales, es necesario entender cómo sus estrategias de afrontamiento impactan su bienestar. Objetivo: analizar la relación entre las estrategias de afrontamiento y el tecnoestrés en docentes de la parroquia rural Bachillero del cantón Tosagua en la provincia de Manabí, Ecuador. Metodología: se utilizó un enfoque cuantitativo, de tipo no experimental y transversal con alcance descriptivo. La muestra estuvo compuesta por 33 docentes de las tres unidades educativas de la parroquia. Se aplicaron la Escala Multidimensional de Evaluación de los Estilos de Afrontamiento (BRIEF-COPE/28) y el Cuestionario RED TIC como instrumentos de evaluación. Resultados: los docentes emplean principalmente estrategias de afrontamiento centradas en el problema y en la emoción, destacando el afrontamiento activo. Se observó una alta prevalencia de síntomas relacionados con el tecnoestrés. Además, se encontraron correlaciones positivas moderadas entre diversas estrategias de afrontamiento y las manifestaciones de tecnoestrés. Conclusión: las combinaciones de estrategias de afrontamiento adoptadas por los docentes se asocian con distintos niveles de bienestar.
Dificultades de Regulación Emocional en Estudiantes de Nivelación
Authors: Moya-Lara Ivonne Nataly
Published: February 2025

Justification: the transition to university life represents a critical period filled with unique stressors such as academic pressure, financial independence, and adaptation to a competitive environment. These challenges highlight the importance of emotional regulation, defined as the ability to manage and respond appropriately to emotions. Objective: analyzing the relationship between difficulties in emotional regulation and demographic factors such as gender, age, and socioeconomic status among preparatory students at a public university in Manta, Ecuador. Methodology: Using a non-experimental, cross-sectional quantitative design, data were collected from a sample of 348 students through online questionnaires. The Difficulties in Emotion Regulation Scale (DERS) was used to measure emotional difficulties, showing high internal consistency (α = ,939). Results: The results showed high difficulty in emotion regulation among the participants, with elevated mean scores in subscales such as Non-Acceptance and Control. The analysis revealed that difficulties in emotion regulation are significantly associated with the investigated demographic factors, although specific details and differences vary. Conclusion: Difficulties in emotion regulation have a significant impact on the university experience, affecting both well-being and academic performance.
Masques et playback : traditions du geste et devenirs de l’acteur dans le théâtre de Susanne Kennedy
Authors: Jan Corentin
Published: February 2025

Le théâtre de la jeune metteuse en scène allemande Susanne Kennedy présente des partis pris formels forts: acteurs et actrices masqués, voix en playback pré enregistrés et diffusés en parallèle de l’action scénique, espaces troublés pour une utilisation ambigüe de la vidéo… Loin de se limiter un projet formaliste, l'esthétique de Susanne Kennedy s’appuie avant tout sur un travail novateur mené sur le jeu des comédiens et comédiennes qui, entravés et privés de certaines de leurs ressources habituelles, n’ont de cesse de reconsidérer et d’interroger leur présence sur le plateau. L’analyse de deux spectacles – Warum läuft Herr R. Amok ? et Drei Schwestern –, met en évidence que c’est précisément grâce un travail mené sur le geste théâtral et les traditions allemandes dans ce domaine que s’accomplit cette démarche symptomatique d’une nouvelle génération de la mise en scène sur les scènes germanophones aujourd’hui.
Silkworm Interaction and Its Role in Resistance to Bombyx Mori Nuclear Polyhedrosis Virus: A Genetic and Molecular Review
Authors: Usama Hanif  , Saba Naveed  , Noor Ul Huda  , Jafar Ebrahim Khail  , Muhammad Hasnat Ahmad  , Muhammad Haroon
Published: February 2025

Background: Bombyx mori nucleopolyhedrovirus (BmNPV) is a significant pathogen affecting silkworm populations, leading to substantial economic losses in sericulture. Understanding the genetic and molecular mechanisms underlying host resistance is crucial for developing effective control strategies. Objective: This review aimed to synthesize current knowledge on the genetic and molecular interactions between Bombyx mori and BmNPV, identifying key resistance mechanisms and potential strategies for enhancing antiviral defenses. Methods: A narrative review was conducted using literature from PubMed, Scopus, Web of Science, and Google Scholar. Studies focusing on silkworm immunity, genetic resistance, metabolic pathways, and transgenic approaches were analyzed. Data were synthesized to identify common resistance-associated genes and molecular pathways. Results: Resistance to BmNPV was found to be regulated by dominant and minor genes, metabolic alterations, and immune pathways such as Toll, IMD, and RNA interference. Transgenic silkworms overexpressing antiviral genes demonstrated enhanced resistance without compromising economic traits. Mortality analysis highlighted strain-specific differences in susceptibility. Conclusion: Genetic and metabolic resistance mechanisms play a critical role in BmNPV defense, with transgenic modifications offering a viable strategy for disease control. Findings provide insights into viral resistance models relevant to both sericulture and human virology.
The Application and Development of Modern Technology in Dance Art: A Case Study of the Dance Drama Only This Green
Authors: Bao Qian
Published: February 2025

With the rapid development of technology, modern science and technology have been widely integrated into various fields of artistic creation, especially in dance art. Technology has brought unprecedented innovative opportunities for dance creation and performance, particularly in the enhancement of visual representation, stage design, and audience experience. The dance drama Only This Green serves as a typical work that blends technology with dance art. By utilizing technologies such as virtual reality (VR), augmented reality (AR), and digital projection, it demonstrates the perfect combination of technology and traditional dance forms. This paper explores the application background, development trends, and innovative opportunities brought by modern technology in dance art. Using Only This Green as a case study, it analyzes the specific applications and achievements of modern technology in artistic creation. The article also looks forward to the future trend of the integration of dance art and technology, suggesting future development paths in interdisciplinary collaboration, intelligent creation, and digital dance art creation.
НЕКОТОРЫЕ ФАКТОРЫ ФОРМИРОВАНИЕ ПОДЗЕМНЫХ ВОД ТАКЫРНЫХ И ПОДТАКЫРНЫХ ЗОНАХ
Authors: Акимова Азима Пердебаевна , Очилов Голибжон Ерназаругли , Рахимбаев Отабек Давлатбаевич , Жетписбаева Айзада КауисКизи
Published: February 2025

The article is devoted to the study of natural factors that, to one degree or another, contribute to the formation of lenses of fresh groundwater in limestone and marl strata of Neogene deposits. According to the results of the research, changes in the salinity of soils in depth have been established and the possibility of artificial accumulation of drinking and saturated groundwater, by the method of construction of artificial structures, and underground reservoirs in fractured and karst rocks has been revealed.
Research on Folk Art Design of Manchu Decorative Patterns: From Historical Inheritance to Modern Innovation
Authors: Ding Yuhe , Naeim Fauzi
Published: February 2025

This study focuses on the folk art design of Manchu decorative motifs in China, exploring their relationship with ancestors, neighbouring regions and the universe, and revealing their visual presentation laws and cultural and social values through textual interpretation and dissection. Combining qualitative and quantitative methods, the study analyses the historical and cultural background of Manchu decorative motifs and their transmutation in contemporary culture, with the aim of systematically collating and researching outstanding folk art design culture, and refining the design laws and wisdom with Chinese characteristics, in order to develop and enhance the level of Chinese design, and to strengthen the soft power of culture.
YAŞIL İQTİSADİYYATDA DAYANIQLI İNKİŞAFPRİNSİPLƏRİNİN GÖZLƏNİLMƏSİ
Authors: Turan N. CƏFƏROV
Published: February 2025

Məqalənin yazılmasında əsas məqsəd yaşıl iqtisadiyyatın və onun davamlıiqtisadi inkişafa təsirinin vacibliyini vurğulamaqdır. Yaşıl iqtisadiyyatekoloji davamlılıq, sosial ədalət və iqtisadi inkişaf arasında balansyaratmağa yönəlmiş bir iqtisadi model olaraq təqdim olunur. Məqalədə yaşıl iqtisadiyyatın ətraf mühitin qorunması, karbon emissiyalarının azaldılması, təkrar emal və alternativ enerji mənbələrinin genişləndirilməsi kimi əsas prinsipləri müzakirə edilir. Eyni zamanda, bu yanaşmanın Azərbaycanda ekoloji problemlərin həllində necə mühüm rol oynadığı və ölkədə yaşıl iqtisadiyyatın təşviq edilməsi istiqamətində atılan addımlar da qeyd olunur.  Məqalənin əsas məqsədlərindən biri yaşıl iqtisadiyyatın tətbiqinin ölkənin davamlı iqtisadi inkişafına necə töhfə verə biləcəyini göstərməkdir. Məqalədə qeyd olunan əsas məsələlərdən biri də yaşıl texnologiyaların inkişafının və təbii resursların səmərəli istifadəsinin iş yerlərinin yaradılması və innovasiya imkanlarının genişlənməsi ilə iqtisadi artıma müsbət təsir etməsidir. Nəticə olaraq, məqalə yaşıl iqtisadiyyatın üstünlüklərini və Azərbaycanda davamlı inkişaf hədəflərinə çatmaq üçün bu modelin tətbiqinin vacibliyini izah etməyi hədəfləyir.
Türkdilli Dövlətlərdə Iqtisadi Qeyri- Sabitliyin Əsasi Kimi Monopolya Və Korrupsiya
Authors: ƏLİYEV Ədalət
Published: February 2025

MONOPOLY AND CORRUPTION AS THE BASIS OF ECONOMIC INSTABILITY TURKIC-SPEAKING COUNTRIES
Monopoly And Corruptıon As The Basıs Of Economıc Instabılıty Turkıc-Speakıng Countrıes This topic is one of the most pressing issues across various state activities. The preamble of the UN Convention against Corruption broadly outlines the concer s, convictions, and determination to combat corruption. Monopoly and corruption are factors that undermine a state's economic and national security. They affect science, education, industry, social sectors, the economy, politics, diplomacy, and finance. This article addresses these issues that currently exist in Turkic-speaking countries. It is essential for us, Turks, to understand these issues because without knowing the true causes negatively affecting the development of all sectors in our countries and the lives of their populations, we cannot build a strong unified society of Turkic- speaking states. Only by understanding the real state of affairs in each of our countries can we achieve unity among our peoples and states, with flourishing science, education, social sectors, and democracy akin to that of European Community countries.
Yaşıl İqtisadiyyatda “YAŞIL” Bacarıq və İş Yerləri
Authors: Hüseynova Arzu
Published: February 2025

GREEN SKILLS AND JOBS IN A "GREEN" ECONOMY
The focus of this article is on providing a systematic overview of job criteriaand required skills in the transition to a green economy. With this objective,the article highlights the concepts of "Green" skills and workplaces, theiroverview and relevance. The classification of "Green" workplaces and therequirements for "Green" skills have been determined based on it. 
 
Məqalənin məqsədi yaşıl iqtisadiyyata keçiddə iş yerlərinin meyarları vətələb edilən bacarıqlar haqqında sistemləşdirilmiş icmalın verilməsidir. Buməqsədlə məqalədə “yaşıl” bacarıqlar və iş yerləri anlayışları, onlara baxış,aktuallığı verilmişdir. “Yaşıl” iş yerlərinin təsnifatı və onun əsasında “Yaşıl”bacarığa tələblər müəyyənləşdirilmişdir.
İNSTİTUSİONAL İNNOVASİYA NƏZƏRİYYƏSİNƏSİSTEMATİK BAXIŞ
Authors: Səfər M. HÜSEYNOV
Published: February 2025

İnstitusional innovasiyalar eksponensial dəyişikliklər dünyasındaözünəməxsus şəkildə inkişaf edən ağıllı institutlar yaradır. Siyasətəəsaslanan müdaxilələr və təcrübi öyrənmə vasitəsilə qurumların rəhbərləriyaşamaq və uğur qazanmaq üçün tələb olunan praktiki və böhrana əsaslanan yenilikləri təqdim etməkdə mahir olurlar. Eynilə, institusional innovasiyanın idarə edilməsi, bu innovasiya formasının iqtisadi artımla əlaqəsi və texnoloji tərəqqi, əsas böhranların artması və yeni yaranan sosial-iqtisadi dəyişikliklər nəticəsində davam edən əsas sosial-iqtisadi dəyişikliklərin tələbləri səbəbindən tədqiqata maraq olaraq qalır. çətinliklər. Müvafiq olaraq, ədəbiyyatdan irəli gələn əsas sual cəmiyyətin dəyərini çatdırmaq üçün institusional innovasiyalara təsir edən müəyyənedicilər və prioritetlər dairəsinə aiddir. Beləliklə, institusional innovasiyanın potensialından irmək və inkişaf etdirmək vəzifəsialimlər ordusu üzərinə düşür. Bu məqalənin məqsədi institusionalinnovasiya ilə bağlı tədqiqatların mövcud vəziyyətini təhlil etməkdir.Sistematik nəzərdən keçirmə metodologiyasından istifadə edərəkqiymətləndirmə aparılmışdır. Məzmun institusional innovasiyalarınçoxsəviyyəli idarəetmə modelini inkişaf etdirmək məqsədilə əsasdeterminantları və idarəetmə prioritetlərini tapır. Məzmundan əldə edilənfikirlərə əsaslanaraq, məqalə institusional innovasiyanın gələcək idarəedilməsi üzrə tədqiqatlar üçün tədqiqat gündəmini müəyyən edir.
ÖLKƏMİZDƏ SU TƏCHİZATI VƏ SUYUN TƏMİZLƏNMƏSİ YOLLARI
Authors: Ədalət Bayraməli oğlu ƏLIYEV  , Suma Elxan qızı ZEYNALOVA
Published: February 2025

Məqalədə ölkəmizdə Su təchizatı təsiri və suyun təmizlənməsi yollarımüəyyənləşdirilməsinin nəzəri əsasları, eləcə də bu təbəqənin müəyyənləşdirilməsi üçün tətbiq olunan metodologiya müəllif yanaşması ilə araşdırılmışdır. Eyni zamanda bu sahədə aparılan araşdırmalar tədqiq edilmişdir.
Ethnic profiling: Informe sobre conductas tipificadas que afectan a la calidad de vida en España
Authors: Gascón-Cuenca (tutor) Andrés , Morano García David , Okechi Alawai Whitney Maribel , Casero Julio , Townend Kimberly Jade , Torreño Lerma Carlos , Cardicio Luisa , Mosquera Gironza Mayra A, , Savona Navarro Wanda , Marín Soler Amparo J. , Pelechà Aigües Néstor , Juan Amat Isabel , Crespo Andrea , Puertos García Begoña , García Añón José
Published: February 2025

Introducción. Sobre el problema hermenéutico.
Si bien nos encontramos ante un problema hermenéutico sobre el contenido semántico de los conceptos “desobediencia” y “autoridad”, con su consecuente problema normativo, intentaremos a lo largo del capítulo esquematizar la regulación normativa a nivel nacional y municipal (en el caso de Valencia, Madrid y Barcelona). Para ello, revisaremos la articulación que se hace en los reglamentos y códigos, así como la doctrina jurisprudencial que se aplica en cuestiones relacionadas con la desobediencia a la autoridad.
Empezaremos por exponer aquellos artículos de la Constitución Española (CE) relativos a la materia que nos ocupa. Así, según el art. 9.1 CE cualquier poder público está sujeto a la Constitución, quedando por tanto regido y autorizado por ella. La función de estos poderes es la salvaguarda de los derechos civiles y políticos de los ciudadanos. De esta forma, el artículo 9.2 CE establece que “corresponde a los poderes públicos promover las condiciones para que la libertad y la igualdad del individuo y de los grupos en que se integra sean reales y efectivas; remover los obstáculos que impidan o dificulten su plenitud y facilitar la participación de todos los ciudadanos en la vida política, económica, cultural y social”. Por su parte, el artículo 9.3 CE garantiza el principio de legalidad, la jerarquía normativa y la irretroactividad de las disposiciones sancionadoras que no sean favorables de los derechos individuales y la seguridad jurídica.
Por otro lado, el artículo 103 CE expresa la intencionalidad de la Administración pública, así como su adecuación de la ley al Derecho. Aquélla se servirá de la objetividad de los intereses generales y de los principios de descentralización y coordinación, y prevé la regulación del estatuto de los funcionarios públicos y el acceso a la función pública “de acuerdo con los principios de méritos y capacidad”. En el artículo 104 CE se manifiesta el objetivo perseguido con la creación de las Fuerzas y Cuerpos de seguridad del estado, así como la adecuación de sus protocolos ? de acción con los estatutos reguladores. Las fuerzas y cuerpos de seguridad del Estado tendrán “como misión proteger el libre ejercicio de los derechos y libertades y garantizar la seguridad ciudadana”.
Reagrupación familair
Authors: Fernández Artiach (tutora) Pilar , Ortiz Gisbert Raúl
Published: February 2025

Reagrupación familiar
Infografia Ocupació
Authors: Correcher Mira (tutor) Jorge , Costa Navarro David , Fierrez Soria Sonia , Gregorio Alcaide Yaiza , Hernández Azcon Ainhoa , Jusue Moñino Nerea Gema , Martínez Trigo Amanda , Muñoz Ruíz Rubén , Ramos Miralles Alejandro
Published: February 2025

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Informe sobre el modelo de Barnahus para Save the Children
Authors: García Sáez (tutor) Jose Antonio , Juan Sánchez  (tutor) Ricardo , Ramírez González (tutora) Alejandra , Da Re Giulia , Cubas Gómez Celia , García Monzó Marta , González Iniesta Román , Granell Navarro Ángeles , Torrecillas Martínez Ana , Ferrández Sansano Laura , Tejada Berrocal Agnes Madeliz , Pedrozo Arbeláez Natalia Carolina , Verdú Gómez Jose Antonio , Torres Míguez Ángela Yanira
Published: February 2025

El presente informe surge de un encargo realizado por Save the Children en el mes de octubre de 2019 a la Clínica Per la Justicía Social de la Facultat de Dret de la Universitat de València.
Los objetivos que se establecieron en dicho encargo fueron los siguientes:
1.Realizar un estudio sobre las competencias estatales y autonómicas en materia de actuación ante casos de abuso sexual infantil (ASI) con el fin de determinar su grado de compatibilidad con la implementación del Modelo Barnahus en la Comunitat Valenciana.
2.Realizar un estudio estadístico de los casos de ASI judicializados en la Comunidad Valenciana entre 2016 y 2019.
De manera que el desarrollo de este Informe se divide en dos partes que coinciden con cada uno de los Objetivos.
Informe para la Asociación Española Pro Derechos Humanos (APDHE). Denuncia sobre la falta de independencia del Poder Judicial español en la investigación de los crímenes del franquismo. Valencia, 14 de junio de 2019
Authors: Vanyó Vicedo (tutora) Raquel , Correcher (tutor) Jorge , Esteve Moltó (tutor) José Elias , Juan Sánchez (tutor) Ricardo , García Sáez (tutor) Jose A.
Published: February 2025

Informe para la Asociación Española Pro Derechos Humanos (APDHE). Denuncia sobre la falta de independencia del Poder Judicial español en la investigación de los crímenes del franquismo. Valencia, 14 de junio de 2019.
Propuesta de sanciones de la UE por violaciones de derechos humanos en Guinea Ecuatorial
Authors: Esteve Moltó José Elías , Portela Sais Clara , Vanyó Vicedo Raquel , Del Valle Calzada Estrella , Ferrando Hernández Joan Marc , Massoko Mocache , Fernández Rojas Natalia , Aníbal Mendoza Jairo , Garrido Marcela , Romero Germán , Campos Delgado Marcia , Martínez Rojas Sebastián , Atuesta Tatiana , Plaza Esteban
Published: February 2025

Propuesta de sanciones de la UE por violaciones de derechos humanos en Guinea Ecuatorial
Informe jurídico sobre la situación de la violencia sexual contra la infancia en España, realizado en el marco del VII Ciclo de revisión ante el Comité de los Derechos del Niño
Authors: García Sáez José Antonio , Ramírez González Alejandra , Martínez Quiñones Alejo , Pérez Guerra Ignacio , Ramón Alcaide Joan
Published: February 2025

Este informe es una versión extendida del Informe Alternativo que se presentará ante el Comité de Derechos del Niño en el marco del VII Ciclo de Revisión. Se aborda la situación de la violencia sexual contra la infancia en España, evidenciando los retos normativos y de políticas públicas que el estado español debe abordar a efectos de garanziar el cumplimiento de las obligaciones adquiridas en el marco de la Convención sobre los Derechos del Niño, particularmente lo señalado en sus artículos 19, 24, 28 y 39.
Moderne Aufklärung. Erkenntnisse für die Krisen der Gegenwart, por Johannes Rohbeck
Authors: Genazzano Pablo
Published: February 2025

Ressenya/Reseña/Review
Rohbeck, Johannes 2023, Moderne Aufklärung. Erkenntnisse für die Krisen der Gegenwart, Berlín: J. B. Metzler/Springer. ISBN 978-3-662-66654-8, 299 páginas.
Honneth y Adorno ante la patología: crítica que abre mundo o interpretación materialista de las obras de arte
Authors: Vidal Vanessa
Published: February 2025

Honneth and Adorno faced with pathology: world-opening critique or materialistic interpretation of artworks
Resumen: El artículo presenta una revisión de las lecturas de Dialéctica de la Ilustración que proponen J. Habermas y A. Honneth como filosofía objetivista de la historia o crítica que abre mundo y presenta, frente a ellas, la actualidad de la filosofía crítica de Adorno como interpretación materialista de las obras de arte.
Abstract: This article criticizes J. Habermas’ and A. Honneth’s reading of Dialectic of Enlightenment as an objectivist philosophy of history or a world-disclosing critique, respectively. Instead, it defends the actuality of Adorno’s critical philosophy as a materialist interpretation of works of art.
Palabras clave: crítica, materialismo, filosofía de la historia, interpretación, hermenéutica, teoría crítica.
Keywords: critique, materialism, philosophy of history, hermeneutics, interpretation, critical theory.
Crítica abstracta como “patología”
Authors: Madureira Miriam Mesquita Sampaio de
Published: February 2025

Abstract critique as “pathology”
Resumen: En lo que sigue pretendo poner en discusión el carácter y el sentido de cierta práctica, que se ha popularizado en los últimos años que se mueve entre la denuncia y la crítica. Esa práctica consiste en, generalmente con buenas intenciones, poner de relieve o exponer públicamente acciones o aspectos potencialmente condenables de personas, comportamientos, relaciones, instituciones u obras culturales, y ha sido entendida como parte de cierta “cultura de la cancelación”. Después de aclarar en qué medida se podría caracterizar ese tipo de práctica como “pensar abstracto” en el sentido de Hegel (I), discutiré, haciendo mención a algunas distinciones planteadas por representantes de la Teoría Crítica de la Escuela de Frankfurt, en qué sentido ella se podría interpretar todavía como una forma de crítica (II), por qué sería posible considerarla como “patológica” (III) y, finalmente, en qué sentido, y cómo, a pesar de ello, podríamos entender esa práctica efectivamente como forma de crítica (IV).
Abstract: In what follows, I intend to discuss the character and the meaning of a certain type of practice, located between denunciation and criticism, which has become popular in recent years. This practice consists of putting in relief or exposing publicly, usually with good intentions, actions or potentially condemnable aspects of persons, institutions and cultural works, being often understood as part of a “cancel culture”. After clarifying the extent to which this type of practice could be characterized as “abstract thinking” in the sense of Hegel (I), I shall discuss, using some distinctions from representatives of Frankfurt School Critical Theory, in what sense this practice could be interpreted as a form of criticism (II); why it might be regarded as “pathological” (III), and what meaning, and how, it could still have as a form of criticism (IV).
Palabras clave: pensar abstracto, Hegel, teoría crítica, cultura de la cancelación.
Keywords: abstract thinking, Hegel, critical theory, cancel culture.
Patologías contemporáneas de las relaciones sociales
Authors: Casuso Gianfranco , Herzog Benno , Ortega-Esquembre César
Published: February 2025

Contemporary Pathologies of Social Relations
¿Se puede aplicar el término de patologías, surgido del contexto médico, a entidades sociales? ¿Qué describe exactamente el término de las patologías sociales: unas sociedades que de alguna forma hacen “enfermar” a sus miembros o se puede describir a la sociedad misma como padeciendo una enfermedad? Y finalmente: ¿cuál es la relación entre la sociedad (patológica) y los individuos (patológicos)? También surge una gran cantidad de preguntas sobre la aplicación del concepto a la realidad social. ¿Qué fenómenos se pueden describir con el concepto de patología y a qué partes de la sociedad afecta? ¿Describe a grandes sistemas como el capitalismo o en general al sistema de reproducción social, o más bien hace referencia a la percepción de los individuos, su razón y sus ideologías? ¿Y en qué medida lo primero influye sobre lo segundo? Estas son también las preguntas básicas con las que el presente monográfico pretende contribuir al debate internacional.
Acceptance and reluctance of COVID-19 vaccination among the general population: a systematic review and meta-analysis of cross-sectional studies
Authors: Thiyagarajan Gajalakshmi , Nagasubramanian Vanitha Rani , Ravichandran Seetha Lakshmi , Baskaran Preetha , Thangam Danya Cendhil , Sankaranarayanan Rathiesh Kanna , Undela Krishna , Sridevi Bhima , Pelluri Ranakishor , Gurram Prasada Chowdari , Rajangam Jayaraman
Published: February 2025

The objective of this study was to systematically review the selected literature and identify the rate and reasons for acceptance and hesitancy among the common public toward coronavirus disease 2019 (COVID-19) vaccination in various countries. The systematic review was conducted in compliance with the “Preferred Reporting Project for Systematic Evaluation and Meta-Analysis” recommendations using search words in search engines (PubMed, Scopus, Google Scholar), and the cross-sectional studies were screened based on inclusion and exclusion standards. Institute of Joanna Briggs. A critical analytical checklist was used to evaluate publication bias in the included studies. The analysis was performed using the 4.0.5 version of R. Of the 84 articles screened, 18 were included. Ten articles that assessed the acceptance of COVID-19 vaccination in 22,212 participants reported an overall 59.6% acceptance rate with highest in Malaysia (94.3%) and the lowest in Hong Kong (42.2%). The proportion of the vaccination acceptance rate published in 16 studies with weighted mean difference (WMD) was 63.79% (95% CI: 54.19%–73.39 %; I2 = 100 %; p < 0.00001), and the proportion of hesitancy rate in 8 studies with WMD was 25.13% (95% CI: 17.21%–33.06%; I2 = 100 %; p < 0.00001). Hesitancy to get vaccinations was due to concerns about adverse consequences, lack of reliability, belief as a biological weapon, newness, issues regarding effectiveness and safety, and not wanting to be the first to receive the vaccination. COVID-19 vaccine acceptability rates overall were around 64%, and concerns about vaccine safety had led to hampered vaccination promotion among the public.
Cortico-striatal action control inherent of opponent cognitive-motivational styles
Authors: Avila Cassandra , Sarter Martin
Published: February 2025

Turning on cue or stopping at a red light requires attending to such cues to select action sequences, or suppress action, in accordance with learned cue-associated action rules. Cortico-striatal projections are an essential part of the brain’s attention–motor interface. Glutamate-sensing microelectrode arrays were used to measure glutamate transients in the dorsomedial striatum (DMS) of male and female rats walking a treadmill and executing cued turns and stops. Prelimbic–DMS projections were chemogenetically inhibited to determine their behavioral necessity and the cortico-striatal origin of cue-evoked glutamate transients. Furthermore, we investigated rats exhibiting preferably goal-directed (goal trackers, GTs) versus cue-driven attention (sign-trackers, STs), to determine the impact of such cognitive-motivational biases on cortico-striatal control. GTs executed more cued turns and initiated such turns more slowly than STs. During turns, but not missed turns or cued stops, cue-evoked glutamate concentrations were higher in GTs than in STs. In STs, turn cue-locked glutamate concentrations frequently peaked twice or three times, contrasting with predominately single peaks in GTs. In GTs, but not STs, inhibition of prelimbic–DMS projections attenuated turn rates and turn cue-evoked glutamate concentrations and increased the number of turn cue-locked glutamate peaks. These findings indicate that turn cue-evoked glutamate release in GTs is tightly controlled by cortico-striatal neuronal activity. In contrast, in STs, glutamate release from DMS glutamatergic terminals may be regulated by other striatal circuitry, preferably mediating cued suppression of action and reward tracking. As cortico-striatal dysfunction has been hypothesized to contribute to a wide range of disorders, including complex movement control deficits in Parkinson’s disease and compulsive drug taking, the demonstration of phenotypic contrasts in cortico-striatal control implies the presence of individual vulnerabilities for such disorders.
Pupil dilation offers a time-window on prediction error
Authors: Colizoli Olympia , van Leeuwen Tessa , Rutar Danaja , Bekkering Harold
Published: February 2025

Task-evoked pupil dilation has been linked to many cognitive variables, perhaps most notably unexpected events. Zénon (2019) proposed a unifying framework stating that pupil dilation related to cognition should be considered from an information-theory perspective. In the current study, we investigated whether the pupil’s response to decision outcome in the context of associative learning reflects a prediction error defined formally as information gain, while also exploring the time course of this prediction error signal. To do so, we adapted a simple model of trial-by-trial learning of stimulus probabilities based on information theory from previous literature. We analyzed two data sets in which participants performed perceptual decision-making tasks that required associative learning while pupil dilation was recorded. Our findings consistently showed that a significant proportion of variability in the post-feedback pupil response during decision-making can be explained by a formal quantification of information gain shortly after feedback presentation in both task contexts. In the later time window, the relationship between information-theoretic variables and the post-feedback pupil response differed per task. For the first time, we present evidence that whether the pupil dilates or constricts along with information gain seems to be context dependent, specifically related to increasing or decreasing average uncertainty (entropy) across trials. This study offers empirical evidence showcasing how the pupil’s response can offer valuable insights into the process of model updating during learning, highlighting the promising utility of this readily accessible physiological indicator for investigating internal belief states.
SATAY-based chemogenomic screening uncovers antifungal resistance mechanisms and key determinants of ATI-2307 and chitosan sensitivity
Authors: Karadzas Matthew T , Michel Agnès H , Mosbach Andreas , Giannakopoulos George , McGettigan Ruairi , Scalliet Gabriel , Kornmann Benoît
Published: February 2025

Multidrug-resistant fungal pathogens are a serious threat to public health and global food security. Mitigation requires the discovery of antifungal compounds with novel modes of action, along with a comprehensive understanding of the molecular mechanisms governing antifungal resistance. Here, we apply SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing method in
Saccharomyces cerevisiae
, to uncover loss- and gain-of-function mutations conferring resistance to 20 different antifungal compounds. These screens identify a diverse array of novel resistance mechanisms and multiple modes of action. SATAY is performed in drug-sensitive strains to generate chemogenomic profiles for compounds that lack activity against conventional laboratory strains. This study therefore provides a significant resource for exploring cellular responses to chemical stresses. We discover that the natural antifungal Chitosan electrostatically interacts with cell wall mannosylphosphate, and that the transporter Hol1 concentrates the novel antifungal ATI-2307 within yeast. This latter finding presents an avenue for drug design initiatives, but also unveils a straightforward evolutionary path to ATI-2307 resistance with minimal fitness cost.
Tuck-KGC: based on tensor decomposition for diabetes knowledge graph completion model integrating Chinese and Western medicine
Authors: ZhangSun Jiangtao , Yang Yu Xin , Zou Beiji , Peng Qinghua , Xiao Xiao Xia
Published: February 2025

The medical knowledge graph is essential for intelligent medical services, encompassing personalized diagnostics, precision therapies, and intelligent consultations, among others. However, medical knowledge graphs frequently suffer from incompleteness, primarily due to the absence of certain entities or relationships. The incomplete nature of knowledge graphs poses substantial challenges to these tasks. Knowledge graph completion technology is instrumental in addressing this issue. Specifically, tensor decomposition-based approaches for knowledge graph completion embed entities and relationships into the vector space, where tensor decomposition computations are employed to predict missing relationships within the knowledge graph. However, the tensor representation of entities and their relationships often overlooks crucial entity type information, potentially resulting in an abundance of irrational relationships during the prediction process. To mitigate this, we propose the Tucker Decomposition Knowledge Graph Completion (Tuck-KGC) method, which incorporates entity types into the tensor decomposition framework. This method maps the types of medical entities to vectors, which are seamlessly integrated into the knowledge graph representation learning process. This allows the model to thoroughly absorb entity information, thereby enhancing the accuracy of link prediction. To evaluate the Tuck-KGC, we built the Dia dataset, a knowledge graph tailored for precision medical analysis, which integrates both Traditional Chinese Medicine and Western medicine perspectives. The Dia dataset encompasses 10,294 entities with 214 relationships, covering a comprehensive spectrum including diseases, treatments, clinical manifestations, complications, etiology, and so on. Building upon the Dia dataset, experimental results indicate that the Tuck-KGC model boosts link prediction accuracy by roughly 8%, affirming the efficacy of incorporating entity type information into the model.
Active site titration of bovine β‐trypsin by Nα‐(N,N‐dimethylcarbamoyl)‐α‐aza‐lysine p‐nitrophenyl ester: kinetic and crystallographic analysis
Authors: Sartori Patrizia , Carugo Kristina Djinovic , Ferraccioli Raffaella , Balliano Gianni , Milla Paola , Ascenzi Paolo , Bolognesi Martino
Published: July 2002

Kinetics of bovine β‐trypsin (trypsin) with the N

α
‐(N,N‐dimethylcarbamoyl)‐α‐aza‐lysine p‐nitrophenyl ester (Dmc‐azaLys‐ONp) was obtained at pH 6.2 and 21.0°C. Dmc‐azaLys‐ONp shows the characteristics of an optimal active site titrant in that it (i) gives titrations in a short time, (ii) is a stable and soluble compound with a stoichiometric reaction that is easily and directly detectable, and (iii) allows titrations over a wide range of enzyme concentration. Moreover, the three‐dimensional structure of the trypsin · N

α
‐(N‐N‐dimethylcarbamoyl)‐α‐aza‐lysine acyl · enzyme adduct has been solved by X‐ray crystallography at 2.0 Å resolution (R = 0.145). The Dmc‐azaLys moiety of the active site titrant is sited in the serine proteinase reaction center, and is covalently linked to the OG atom of the Ser195 catalytic residue.
The mechanism of methane and dioxygen activation in the catalytic cycle of methane monooxygenase
Authors: Shteinman Albert A.
Published: July 2002

The binuclear structure of the active center of methane monooxygenase plays a determining role in dioxygen activation and in selectivity and specificity of alkane oxidation with this enzyme. A new mechanism is suggested for binding and activation of O2, which involves side‐on binding of O2
2− to iron atoms followed by its conversion to the bis‐μ‐oxo complex considered as an alternative of ferryl in CH4 activation. This mechanism results in the sequence of the cleavage of the O—O bond of peroxide O/O2− instead of the opposite sequence O2−/O, which takes place in the case of heme monooxygenase cytochrome P‐450. Therefore, in this case there is no necessity of the charge relay system [N.B. Gerber and S.G. Sligar, J. Am. Chem. Soc. 114 (1992) 8742] for the transformation of O2 to an active intermediate. The experiment for checking this hypothesis is suggested.
cDNA analysis of the mite allergen Lep d 1 identifies two different isoallergens and variants
Authors: Schmidt Margit , Olsson Susanna , van der Ploeg Ingeborg , van Hage-Hamsten Marianne
Published: July 2002

For the first time the complete cDNA encoding two isoallergens of the non‐pyroglyphid dust mite Lepidoglyphus destructor, Lep d 1, allergen has been sequenced. In addition, one of the isoallergens was found to have two variants. Oligonucleotides were designed from known amino acid sequences. The cDNA sequences were obtained by hybridizing these primers to mRNA and enhancement by the RT‐PCR technique. To obtain the different complete encoding cDNA sequences and eliminate heteroduplex artifacts, we performed PCR + 1 reactions. Comparison of the amino acid sequence of the allergen shows leader sequences of 16 amino acids for both isoforms.
Electromyographic activity in cervices with very low Bishop score during labor
Authors: Pajntar M. , Verdenik I.
Published: July 2002

Objectives: To investigate the activity of the smooth muscles in the cervix at the onset of induced labor and to further elucidate this activity in relation to uterine contractions and to the duration of the latent phase of labor, taking cervical ripeness into account. Methods: Cervical electromyographic (EMG) activity was studied at the onset of labor induced with amniotomy and oxytocin. Bipolar measurement of cervical electrical activity was performed. The root mean square of the cervical EMG activity and the intensity of intrauterine pressure in two groups of parturients with different cervical ripeness were compared. Results: The EMG activity was higher in the group with lower Bishop scores. We found a significant positive correlation between EMG activity and duration of the latent phase of labor. Conclusion: Smooth muscles in the human cervix are active during labor and act to some extent independently of the uterine corpus.
Avian olfactory neurogenesis
Authors: Lièvre Christiane Ayer‐Le , Lapointe Françoise , Leibovici Michel
Published: July 2002

Summry— Chemodetection represents one of the more primitive ways in which animals acquire information about their environment. Olfaction, and elaborate form of chemodetection, is common to every species of vertebrae. The mechanisms of olfaction have been particularly studied in rodents, although their olfactory organ, the olfactory epithelium, paradoxically presents the highest degree of complexity. For some years now, we have been interested in the avian olfactory system which is less complex than its mammalian counterpart. Like humans, birds are microsmatic and present the same basic characteristics as other air breathing species. In this review, we propose to discuss several aspects of the maturation of the olfactory system during development, paying particular attention to recent advances in this field.
Domain 2 of gelsolin binds directly to tropomyosin
Authors: Maciver Sutherland K. , Ternent Diane , McLaughlin Paul J.
Published: July 2002

Gelsolin is an actin filament severing protein composed of six similar structured domains that differ with respect to actin, calcium and polyphospho‐inositide binding. Previous work has established that gelsolin binds tropomyosin [Koepf, E.K. and Burtnick, L.D. (1992) FEBS Lett. 309, 56–58]. We have produced various specific gelsolin domains in Escherichia coli in order to establish which of the six domains binds tropomyosin. Gelsolin domains 1–3 (G1–3), G1–2 and G2 all bind tropomyosin in a pH and calcium insensitive manner whereas binding of G4–6 to tropomyosin was barely detectable under the conditions tested. We conclude that gelsolin binds tropomyosin via domain 2 (G2).
Correlation of the changes of the frequency of perichromatin granules with the RNA content of the interchromatin region of uterine cells in normal and ovariectomized rats. A high resolution in situ hybridization and stereological study
Authors: Vázquez‐Nin Gerardo H. , Jiménez‐García Luis F. , Echeverría Olga , Guzmán Aída , Coeto‐Barona Georgina , Nava‐Ruiz Concepción
Published: July 2002

The changes in the number of perichromatin granules (PCG) and the alterations in the RNA content of the interchromatin and perichromatin regions caused by ovariectomy and estradiol injection were studied in rat endometrial fibroblast and myometrial muscle cells. Twelve rats were divided in four groups. A group of rats was fixed without any treatment, the other three groups were ovariectomized and processed 21 days after the operation. One of them was studied without further treatment, and two groups were injected intraperitoneally with 20 μg of 17 β‐estradiol hemisuccinate and fixed 0.5 and 2 h after the injection. The frequency of PCG was evaluated in preparations stained with EDTA procedure preferential for RNP. The alterations of RNA content were estimated by post‐embedding high resolution in situ hybridization using a total DNA probe labeled with biotinilated nucleotides revealed by streptavidin coupled with 10 nm gold grains. Most of the non‐nucleolar labeling is associated to RNP containing fibrils. Perichromatin and interchromatin granules are labeled to a lesser extent. Castration brings about a reduction of the number of PCG and of the numerical density of labeling in endometrial fibroblasts. The injection of estradiol causes a rapid increase in both parameters. On the contrary, the frequency of PCG and intensity of labeling of epithelial endometrial cells and in muscle cells increase after ovariectomy and are reduced by estradiol administration. These results suggest that estradiol may affect differentially various types of target cells in the same organ, and also that PCG are not the only nuclear compartment of pre‐mRNA or mRNA altered by the changes in estradiol, the RNP containing fibrils located in the perichromatin and in the interchromatin regions are also involved.