bluuebunny/crossref_metadata_2025 huggingface dataset:
Phenolic and Flavonoids Contributions to the Antioxidant, Antidiabetic, and Anticholesterol Activities of Eriobotrya japonica Fruit Extract: An In Vitro Analysis
Authors: . Masfria , H Syahputra , G Haro , L R Nasution
Published: December 2024

Eriobotrya japonica has been traditionally used for its medicinal properties. This study investigates its fruit ethanol extract's phenolic and flavonoids profiles and evaluates its antioxidant, antidiabetic, and anticholesterol activities. Eriobotrya japonica fruit ethanol extract was tested for total phenolic and flavonoid content using Folin-Ciocalteu and AlCl3 methods. The antioxidant capacity was assessed by DPPH and metal chelation assays. The antidiabetic action was assessed using α-glucosidase inhibition and the Nelson-Somogyi method, whereas the Liebermann-Burchard method was used to measure anticholesterol. The extract exhibited large quantities of phenolics (38.62 mg GAE/g) and flavonoids (4.23 mg QE/g), demonstrating robust antioxidant activity with IC50 of 55 μg/mL by DPPH method and substantial inhibition (71%) by metal ion chelation. In addition, it exhibited strong antidiabetic effects 2.42 μg/mL in the α-glucosidase inhibition test, and at 10 μg/mL using the Nelson-Somogyi method resulted in a 24.02% yield. The extract demonstrated a significant reduction in cholesterol levels during the process of cholesterol reduction, obtaining a maximum reduction of 47.31% at the highest concentration tested. Ethanol extract of Eriobotrya japonica can be used in treating oxidative stress and diabetes and introduce its potential to reduce cholesterol levels. The high content of phenolic and flavonoids total contributes to its bioactivities, indicating its potential as a functional food ingredient.
Development and Evaluation of a Nanogel Formulation of Oxaprozin
Authors: S Bhardwaj , N Kalra , W Khan
Published: December 2024

The proposed work was aimed to Development and evaluation of a nanotechnology based formulation of oxaprozin. The preformulation studies for the chosen medication Oxaprozin include IR spectroscopy, melting point determination, and physical appearance analysis as methods of identification. It can be inferred from the Eudragit S-100 DSC overlay thermogram of the physical mixture and the pure drug demonstrates that the drug and excipients do not interact. According to Oxaprozin's UV spectra, the drug exhibits absorbances, with the highest absorbance occurring at 285 nm when the solution is made in methanol. Homogenicity, particle size, pH, drug content, in vitro drug release, skin irritation test, spreadability, extrudability, and viscosity were all optimized in the formulation of the nanogel. The drug content (±SD 98.9 ± 0.02), in vitro drug release (%), and spreadability (g.cm/s) of the optimized F7 formulation are 95.85 ± 0.0658 and 6.5 ± 0.3, respectively. 281 ± 0.5 is the extrudability (g). The viscosity of in cp at 50 (rpm) 9857 were found.
Development and Optimization of Nateglinide Loaded Polymeric Sustained Release Microspheres
Authors: A Vanjari , M Chauhan , P Newadkar , A Nikam
Published: December 2024

This research study aims to develop and characterize of polymeric sustained release microspheres of Nateglinide (NTG), anti-diabetic drug known for its shorter half-life, which leads to poor bioavailability and frequent dosing. NTG polymeric microsphere developed by Emulsion-Solvent Diffusion-Evaporation method. Ethyl cellulose was used as rate retarding material. The polymeric microsphere were characterised for % yield, encapsulation efficiency, drug release, FTIR, and SEM. The developed NTG polymeric microspheres were smooth and spherical with porous nature and showed entrapment efficiency in range of 59.43% - 88.47 % with highest percent yield of 98.75%. FTIR spectra showed drug excipient compatibility while optimized formulation F5 showed complete drug release up to 24 hrs. These results indicate that NTG microspheres offer a safe and effective drug delivery system with prolonged release, which can enhance bioavailability, improve patient compliance, and reduce dosing frequency.
Tuning Synthesis Parameters for Eco-friendly Iron Oxide Nanoparticles Using Pimenta dioica Extract
Authors: AR Bolaj , SP Mahaparale .
Published: December 2024

The fabrication of iron oxide nanoparticles (IONPs) through green synthesis techniques with Pimenta dioica extract, focusing on the effects of extract proportion, reaction time, temperature, pH, and stirring speed (RPM) on nanoparticle properties. The aim is to identify optimal conditions for producing IONPs with desirable characteristics for biomedical applications. The process involved combining extract, FeCl2 (Ferric chloride) and FeSO4 (ferrous sulphate) with 25% ammonia, then subjecting to calcination. The properties of the obtained nanoparticles were assessed, including particle size, zeta potential, thermal stability, magnetization, entrapment efficiency, and drug release. Optimal conditions were found to be a 2:1 extract proportion, 2-3 hours synthesis time, 60-80°C temperature, pH of 10-11, and 900 RPM. Under these conditions, the IONPs exhibited small particle sizes, high thermal stability, high magnetization, and high drug release rates. This study highlights the potential of Pimenta dioica extract in the green synthesis of IONPs, providing insights for optimizing nanoparticle synthesis for medical applications.
A Comparative Study of Branded and Generic Drugs: Cost Analysis in Indian Scenario
Authors: TA Prasad , A Panesar , A Suttee
Published: December 2024

Rising medicine costs adversely affects the access to healthcare and the economic status of households. Branded medicines are priced significantly higher than their generic equivalents (identical therapeutic value), even after the patent expiry. With governments pushing for greater adoption of generics, price remains the critical factor.
Objective: To understand the status of research into the ‘Pharmacoeconomics’ of generic medicine and test the fundamental premise of unbranded generic drugs being cheaper than branded drugs by conducting a comprehensive cost analysis in the Indian situation.
Methods: A qualitative analysis of the top-cited Scopus-indexed research papers published since Covid 19 (2020) has been carried, to understand the status of research into the ‘Pharmacoeconomics’ of generics, using VOSviewer (version 1.6.10). Quantitative cost analysis of branded drugs against their ‘cost-effective’ unbranded counterparts (generics) has been performed using current prices of drugs (solo-formulations) across the top 5 therapeutic categories.
Results: The bibliometric analysis indicates a strong positive association between volume of research and the adoption of generic medicine in a country. Though the fundamental premise of unbranded generic drugs being cheaper has been validated by and large, the possibility of it being vitiated is not ruled out. Highest cost variation was found in cardiology, respiratory and anti-diabetic segments.
Conclusions: India needs to increase its research and cross linkages in the domain of generic medicine to increase awareness and thereby adoption of generic medicine. Special attention needs to be paid on improving the efficiency and quality of local generic manufacturing plants to ensure cost effectiveness of generics.
Nanocrystal Formulation of Manidipine HCl: An Attempt to Enhance Solubility of Poorly Soluble Drug
Authors: AB Jadhav , RB Nawale , S Thorat
Published: December 2024

Background: Manidipine Hydrochloride (MND) is a long-acting dihydropyridine-type calcium antagonist and antihypertensive drug categorized under the Biopharmaceutics Classification System (BCS) Class II. Despite its therapeutic benefits, MND suffers from poor physicochemical and biological properties due to its high lipophilicity and low aqueous solubility, which pose challenges to formulation and drug delivery. Improving the solubility of such hydrophobic drugs is crucial for enhancing their bioavailability. While conventional methods for solubility enhancement exist, drug nanocrystal systems have emerged as a promising approach for addressing solubility issues in poorly soluble drugs.
Objective: To formulate and evaluate nanocrystals of MND using spray-drying technology to enhance its solubility and address limitations associated with its hydrophobicity.
Method: MND nanocrystals were prepared using a spray-drying technique, a cost-effective and scalable method that converts liquid formulations into dry powder through atomization and drying processes. The spray-dried nanocrystals were characterized by their particle size, morphology, solubility, and dissolution rate. Comparative studies evaluated the solubility enhancement achieved with the nanocrystals versus raw MND.
Result: The nanocrystals demonstrated a significant reduction in particle size and enhanced surface area, resulting in improved aqueous solubility and dissolution rates compared to raw MND. Spray-drying facilitated the uniform formation of nanocrystals, ensuring better dispersion and dissolution performance.
Conclusion: Spray-dried MND nanocrystals proved to be a viable strategy for overcoming solubility and bioavailability challenges. This approach offers a promising avenue for enhancing the clinical efficacy of poorly soluble drugs like MND.
Nanosponges: Revolutionizing Medical and Pharmaceutical Sciences
Authors: VR Nagare , SG Talele , DH Patil
Published: December 2024

Long-term efforts to develop a system which will not be hampered by the complex long process which is needed to create a good dose delivery system. It is due to mixture of both water loving and hating drug categories. A system consists of good nanotechnology to prepare sponges which will be of nanosized and will provide a good result and potency and to detect an activity causing toxicity, reducing rate of absorption and good release of active constituent. Due to reduction in size and having pores with good 3D structure. This properties will be effective in treating various symptoms or disease like cancer, disease related to autoimmune system. This data will help in providing basic information about good and bad effects with mode of methods to prepare and to characterize with maximum expansion in developing nanosponges.
Impact of Disease Duration on ADMA and Vitamin D Levels in Children with Nephrotic Syndrome
Authors: Sayed Samira Zain , Mohamed , Engy Ramadan , Moustafa M Tarek A. , Ali Lamia Hamdy , Mahgoob Mohammed Hashem
Published: December 2024

Aim: To investigate the relationship between disease duration, ADMA levels, and vitamin D deficiency in children with
nephrotic syndrome compared to healthy controls.
Background: Nephrotic syndrome (NS) is a pediatric kidney disorder characterized by proteinuria, hypoalbuminemia,
hyperlipidemia, and edema, often leading to cardiovascular and metabolic complications. ADMA, a marker of
endothelial dysfunction, and vitamin D deficiency are significant concerns in NS management.
Methods: This study included 25 children with NS and 25 healthy controls matched for age and sex. Serum ADMA and
vitamin D levels were measured using enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed
to evaluate the relationship between disease duration and the biomarkers.
Results: Children with NS showed significantly higher ADMA levels and lower vitamin D levels compared to controls.
Disease duration was positively correlated with ADMA and negatively correlated with vitamin D levels.
Conclusion: Prolonged NS is associated with increased endothelial dysfunction and vitamin D deficiency, highlighting
the need for comprehensive monitoring and targeted interventions to reduce cardiovascular and metabolic risks in
affected children.
Plasma Soluble Suppression of Tumorigenicity-2 Level with Colchicine in Coronary Artery Disease
Authors: Setouhi Amr , Maghraby K , Abdelsayed M. , Mahmoud Hossam Eldin M.
Published: December 2024

Recently, suppression of tumorigenicity 2 (ST2) of the interleukin 1 receptor family has become an important biomarker
in cardiovascular disease, more precisely in coronary artery disease. This review discusses two isoforms of ST2: the
membrane-bound ST2L and its soluble form, sST2. Specifically, the interaction between sST2 and IL-33 is quite
important; while IL-33 exerts actions to induce inflammatory responses, sST2 acts as a decoy receptor in suppressing
such actions and reflects myocardial stress. High circulating levels of sST2 have been associated with poor clinical
outcomes of CAD, and increased risks for MACE and all-cause mortality have been mainly seen in patients with type 2
diabetes mellitus. Despite this, the long-term prognostication of sST2 has remained largely unexplored, with very few
data available in the literature regarding its predictive value in large cohorts with extended follow-up periods. Other
issues are that colchicine may further exert an additive salutary effect on the cardiovascular component in gout-either
directly or indirectly through regulation of sST2 levels. Placebo-controlled studies revealed that colchicine reduced
inflammatory markers, thereby reducing the rate of MACE in CAD patients.Thus, the possible integration of sST2
measurement into clinical practice might finally translate into some real improvement in risk stratification and the
management strategy in CAD patients. Therefore, large prospective studies will be needed to fully delineate the
relationship of sST2 with CAD outcomes and its relationship to possible treatments, including colchicine. This review
thus discusses the need for more research studies in defining the role of sST2 as a biomarker in cardiovascular health for
further improvement in CAD patient management outcomes
Expression of minichromosome maintenance proteins in the exfoliated cells supplement sputum cytology in the diagnosis of lung cancer
Authors: Panakkal Neeraja , Lekshmi Asha , Krishna K. M. Jagathnath , Saraswathy Veena Vemadevan , Sujathan Kunjuraman
Published: December 2024

Objective:

Sputum cytology is recognized as a straightforward and noninvasive way to diagnose lung cancer, although its clinical utility has not yet been investigated. The objective of the study was to detect and classify cancerous cells in sputum by examining their expression of minichromosome maintenance proteins (MCM2 and MCM7). In addition, the study attempted to evaluate these proteins’ potential as biomarkers of lung cancer lesions and their relationships with clinicopathological characteristics.

Material and Methods:

MCM2 and MCM7 expression in sputum samples was evaluated using immunocytochemistry in sputum cell blocks (n = 97), and their correlation with clinicopathological features was examined. Diagnostic performance was evaluated as a function of sensitivity and specificity.

Results:

Immunoexpression of MCM2 and MCM7 was confined to the nuclei of malignant cells alone, suggesting its potential as a differential diagnostic marker. They showed significant correlations with tumor cytology (P < 0.001), while MCM7 alone exhibited a significant correlation with tumor stage (P = 0.014). The overexpression of these markers was notably pronounced in lung adenocarcinoma compared to other subtypes. In terms of characterizing malignant cells, MCM7 protein demonstrated the highest sensitivity at 92% with an area under the curve (AUC) of 0.961, whereas MCM2 had a sensitivity of 80% and AUC of 0.901.

Conclusion:

This study presents the inaugural use of MCM7 immunocytochemistry on exfoliated cells in sputum samples, proposing that analyzing immunocytochemical markers in sputum could serve as a cost-effective approach for diagnosing lung cancer. Integrating these assessed markers into routine cytopathology laboratories could augment traditional morphological evaluations, thereby improving the sensitivity of sputum cytology.
Planktonic Foraminifera Biostratigraphy Of Taeno Limestone, Ambon, Maluku Province, Indonesia
Authors: Zulfiah  , Aponno Sanny V. , Elly Erfin
Published: December 2024

The limestone became exposed to the surface because of an uplift event during the Quaternary period. This study aims to determine the age of limestone outcrops in the Taeno Traverse using planktonic foraminifera. This research located in Negeri Rumah Tiga, Teluk Ambon District, Ambon City. Field observations and laboratory analysis comprise the two steps of the study methodology. Employ the measuring section approach to gather detailed data in the field. There are 12 layers in the track, totaling 5.34 meters in thickness and 16.5 meters in length. Foraminifera samples prepared in the laboratory using H2O2 extraction and each sample's planktonic foraminifera taxa were identified. Nineteen samples were processed and confirmed to be fossilized planktonic foraminifera. A binocular stereo microscope with a 40x magnification used to analyze the data. The Taeno traverse is composed of calcarenite, a type of clastic limestone. The main characteristics include brownish-grey color, good sorting, sand particle size, open packing, and rounded-subrounded grain shape. Based on the identification results, 30 taxa of planktonic foraminifera fossils were found. The species with the highest abundance are Globorotalia tumida tumida, Globorotalia menardii menardii, Neogloboquadrina incompta, Pulleniatina obliquiloculata, Orbulina universa, Globigerinoides tenellus, and Spaerodinella deshiscens. According to the biodatum results, the Taeno Traverse is part of the Globorotalia ttruncatulinoides truncatulinoides zone with Globigerinella calida calida, Globorotalia tosaensis tosaensis, and Globorotalia crassaformis crassaformis sub-biozonation. This zone shows the age range of N21-N23, or equivalent to the Pleistocene.
Analysis Of Community And Practitioner Perceptions Of Biopori-Based Water Treatment Technologies In The Context Of Flood Resistance
Authors: Rahmawati  , Nurhapsa  , Fahmi Ahmad
Published: December 2024

This study explores the differences in perception between communities and practitioners regarding biopori-based water management technology in the context of flood management in Passeno Village, Baranti District, Sidenreng Rappang Regency, South Sulawesi Province, Indonesia. Employing a quantitative approach, the study involved 30 respondents, consisting of 27 members of farmer groups and 3 practitioners. Data were collected through surveys using structured questionnaires and analyzed using descriptive and inferential statistical techniques. The results indicated that communities rated the effectiveness and ease of implementation of biopori technology higher than practitioners did. The main obstacles identified were a lack of knowledge and government support, with proposed solutions including intensive investigations and government subsidies. Although no significant differences in perception were found between the two groups, this study emphasizes the importance of education, government support, and field experience in influencing the acceptance of biopori technology. The uniqueness of this research lies in its specific focus on biopori technology, the rare comparison of perceptions between communities and practitioners, and its systematic quantitative approach. Additionally, the study successfully identifies obstacles and practical solutions while encouraging better collaboration between communities and practitioners, thereby potentially providing significant contributions to policies and practices in water resource management in flood-prone areas.
Analysis Of River Ordo In The Tukad Balian Watershed (DAS), Bali Province, Indonesia
Authors: Sinaga Mardame Pangihutan , Simanullang Ady Frenly , Siburian Daniel Tony Edyt , Joko Barita Sianipar  , Sianipar Herna Febrianty , Sianturi Tambos August
Published: December 2024

River order research in Tukad Balian Watershed, Bali Province uses ArcGIS Pro to process ASTER GDEM and National DEM data. The analysis is based on: the area and Perimeter of the Watershed, Watershed Length and Width, Land Slope, Average Height, Order and Level of River Branching. The results obtained for the Watershed show that the morphometric value is an area of 15485,20 hectares, a length of 23,08 km, a land slope of 0,40%, and 5 orders of branching rivers with a total of 665 river sections. The shape of Watershed Tukad Balian roundness index value is 7,2. GIS is an effective system for reducing Watershed morphometric information. The research method used is to directly calculate the morphometric parameters of the Tukad Balian Watershed, Bali Province, namely: Area and Perimeter of the Watershed; Watershed Length and weight; River slop or gradient; Average Height; Order and Level of River Branching; Flow Density; and Watershed Form. The conclusion obtained is: The Tukad Balian watershed is a standard-sized watershed with an area of 15.485,20 Ha an average height of 200 meters above sea level and the main river channel is 10,71 Km long. There a plot sections with a total length of 23,08 Km; The elongated shape of the Tukad Balian watershed is in the medium category, where the Tukad Balian Watershed will not experience major flooding.
Analysis of Determining the Potential for Transit Oriented Development in the Setiabudi District Area, South Jakarta, Indonesia
Authors: Taki Herika Muhamad , Bethany Jaffa Rani  , Muhammad Dimas Elvin Putra
Published: December 2024

Crucial research into Transit Oriented Development (TOD) in the Setiabudi District of South Jakarta highlights its significance as a burgeoning business center. This study examines the TOD framework, which integrates high-density development with transportation systems to foster an efficient urban environment. Emphasizing pedestrian-friendly spaces and diverse land uses, the research employs a literature review method to outline the criteria and principles of TOD, referencing the ITDP TOD Standard 2017. Additionally, the analysis leverages data from other scholarly articles to assess the potential for TOD in Setiabudi, focusing on radius and distance analyses around key transit hubs using Google Maps and Google Earth. Stations such as LRT Dukuh Atas, LRT Setiabudi, and Bendungan Hilir MRT demonstrate high potential for TOD, while MRT Setiabudi Astra and LRT Kuningan Station show moderate potential. Conversely, Rasuna Said LRT Station exhibits low potential for TOD. The implementation of TOD at high-potential stations could yield significant positive impacts, while MRT Setiabudi Astra and LRT Kuningan Stations present opportunities for enhancement. We find that Rasuna Said LRT Station requires further attention to increase its future potential.
Cost-Efficient Digital Elevation Model (DEM) Acquisition on Flume Tank Morphodynamic Observation
Authors: Prasojo Octria Adi , Aufar Adlirrahman , Syahputra Reza
Published: December 2024

Digital Elevation Model (DEM) is well known for providing solutions to the theoretical and application-related problems around geosciences. The use of DEM in flume tank experiment is getting more common nowadays. Flume tank itself is built to simulate the landscape and stratigraphy at laboratory scale. This physical experiment may have tremendous impacts on understanding the sedimentation process in a laboratory-scaled experiment. Normally, the morphodynamic behaviour of a laboratory-scaled deposit in the flume tank experiment would be observed through its digital elevation model. In this paper, a novel method in constructing cost-efficient digital elevation model was presented. By using this inexpensive tool to create a digital elevation model in a flume tank experiment setup, some challenges and benefits will follow this method. Some challenges including tool’s resolution and time consuming could be diminished in the near future by creating automated motor system to move the laser distance meter sequentially. Automated and integrated system from the LDM to the processing software could also reduce the time consumption. In the other hand, some benefits including financial benefit, reliability in a sedimentary structure scale, and also the practicality to be applied in any flume tank system available in Indonesia. Nevertheless, this method had been tested and some reliable results from the previous studies in Quantitative Sedimentology Laboratory, Universitas Indonesia was presented in this paper. Hopefully, some major improvements could be done to get more accurate and detail digital elevation model in the near future.
تحقيق فصل (في الجمع بالسفر وبالمطر) من كتاب المواهب السنية شرح المقدمة الحضرمية للشيخ سعيد باعشن (دراسة وتحقيق)
Authors: باحميد صالح عبدالقادر علي
Published: December 2024

سعى الباحث من خلال هذا البحث العلمي لتسليط الضوء على تحقيق جزء من كتاب علمي فقهي متميز للعلامة باعشن وهو كتاب المواهب السنية شرح المقدمة الحضرمية. وقد هدفنا في هذا البحث للعمل على تحقيق فصل من هذا الكتاب؛ سعيا لإتمام تحقيقه كاملاً، ونشر الموروث العلمي المتميز للفقهاء الحضارم، إضافة إلى بذل الجهد للاستفادة القصوى من هذا الكتاب الفريد، وتمثلت مشكلة البحث في السعي لمعرفة الشيخ باعشن وجهوده الفقهية وكتابه المواهب السنية وترجيحاته الفقهية في الجزء المحقق، وتوصلنا في نتيجة هذا البحث للتعريف بالعلامة باعشن وكتابه المواهب السنية، إضافة إلى فك عبارات الجزء المحقق من ذلك الكتاب، وقد سلك الباحث في عمله في التحقيق إلى تخريج الأحاديث النبوية، والتعليق على بعض المسائل الفقهية، وقد استخدم الباحث في هذا البحث المنهج الوصفي والمنهج التاريخي، وقد قسم البحث إلى مبحثين: المبحث الأول: التعريف بالعلامة باعشن وكتابه المواهب السنية، والمبحث الثاني: تحقيق فصل في (الجمع بالسفر وبالمطر) من كتاب الصلاة من كتاب المواهب السنية شرح المقدمة الحضرمية.
الحث على ترشيد الموارد الاستهلاكية في السنة النبوية: دراسة موضوعية
Authors: الزهران محمد زاهر
Published: December 2024

يدرس هذا البحث موضوعا اقتصاديا مهماً، فيبين معنى ذلك، ثم يأتي بأهم الاحاديث النبوية الواردة في ذلك، ويبين توجيهها، وضوابطها الاقتصادية، وكيفية الاستفادة من هذه المفاهيم في الوقت الراهن اقتصاديا وشرعياً، والهدف الرئيس للبحث: هو دراسة مفهوم ترشيد الاستهلاك كما ورد في السنة النبوية، مع توضيح لمعانيه وأهميته، مع استعراض عدد من الأحاديث النبوية ذات الصلة، ثم بيان كيفية تطبيق هذه المفاهيم في السياق الاقتصادي والقانوني المعاصر، مع اعتماد الدراسة على المنهج الاستقرائي والوصفي، فقد تم جمع النصوص النبوية المتعلقة بالموضوع وتحليلها في المجالين الشرعي والاقتصادي. أما محاور البحث الرئيسية، فهي: تعريف ترشيد الاستهلاك ومعناه في السنة النبوية، ثم الأحاديث النبوية التي تحذر من الإسراف وتشجع على الاعتدال، وبعد ذلك: الضوابط الاقتصادية والشرعية لترشيد الاستهلاك وآثاره. وقد خلص البحث إلى عدة نتائج من أهمها: أن الإسراف والتبذير يؤديان إلى مشكلات اقتصادية واجتماعية وبيئية، والتأكيد على ترشيد الاستهلاك يعزز التوازن المالي على مستوى الفرد والمجتمع، مع الاستشهاد ببعض الأحاديث النبوية التي تقدم توجيهات عملية للحد من الهدر وتحقيق التنمية المستدامة.
A Mind Genomics Cartography of Shopping Behavior for Food Products During the Covid -19 Pandemic
Authors: Harizi Ariola , Trebicka Brunela , Moskowitz Howard , Tartaraj Azeta
Published: December 2024

The study presents a new approach to understand the mind of the persons in order to drive desired action in crisis situation, specifically the COVID-19 pandemic. Understand the mind of the shopper in a pandemic situation, with massive uncertainty, should provide direction for governments and the retail trade to adopt practices and communications which will reassure their customers. This study investigates the nature of what people will do to reassure themselves in the pandemic, and has been executed during the period of the pandemic, making the study relevant to the actual events taking place. The focus of the study is on the likelihood of buying ordinary food, given certain descriptions. The study revealed three mind-sets, clusters of individuals who respond to the pandemic in one of three ways. These are: Mind-Set 1: Focus on sanitation - supply; Mind-Set 2: Focus on budget for lifestyle; Mind-Set 3: Focus on shopping, personal needs, consumption. These mind-sets are distributed through the population, and are not limited to specific age or gender. The paper closes with the PVI, personal viewpoint identifier, to assign a new person to one of the three mind-sets.
Health Tourism and Alternative Medicine: a Study on the Offer and Profile of Establishments nearby Two Hospitals in the City of Porto Alegre-Brazil
Authors: Schander de Almeida Izabel Cristina , Ribeiro Helena Charko
Published: December 2024

Alternative medicine is a term that describes medical treatments that are used instead of traditional therapies. About 40 percent of adults in the United States say they use some form of alternative medicine. We analyze establishments that offer alternative treatments and are located in the vicinity of hospitals that receive health tourists. We found 10 establishments (through Google search) but only 04 responded to the survey. The reason for not performing in the other 06 was: 01 was not in attendance, in 03 it was not possible to contact, 01 was not found and 01 refused to respond. Among those who answered, 03 were not aware of health tourism. All attend patients from outside Porto Alegre and 03 from other states and countries. The percentage of out-of-town patient visits ranged from 0 to 10 percent in two establishments and 31 to 40 percent in two others. Chiropractic and Reike were the most commonly offered therapies, followed by Bach Flowers and others such as Orthomolecular Medicine, Chromotherapy and Aromatherapy. All the establishments have pages in the internet but only in 01 it is possible to obtain information in another language (in English, in the page of the parent company). We conclude that health tourism is still unknown by alternative medicine establishments and that even among those who receive patients from other sources, the movement can be considered small in half of them. Lack of sites in other languages may be a barrier to foreign tourists.
Validating Delone and Mclean Success Model in Hospitals of United Arab Emirates
Authors: Jad Kamilia Abdulmutalib Mohamed , Zainol Zuraidah
Published: December 2024

The UAE is well-known country in providing a high-quality technology-based healthcare. Almost all hospitals in the UAE deploy HIS in public and private hospitals, but this progress is not free from obstacles and challenges. A lack of expertise is the major problem to successfully deploying HIS by hospitals. Despite the ongoing expansion of healthcare technologies in the UAE, there is an absence of a framework that explain how the quality attributes of HIS (system quality, information quality, and service quality) contribute to patients’ satisfaction and boost the intention to use the system on regular bases. Determining the significance of these relationships is crucial to evaluate the framework that correlated them together towards better healthcare service. The aim of this study is to validate the Delone and McLean success model in healthcare domain, in particular the adoption of HIS in Al-Sharjah public hospitals Hence, quantitative methodology based on SEM was adopted to achieve this aim. A number of 428 questionnaires out of 500 distributed copies were used for data analysis. The result revealed that system quality, information quality, and service quality have significant effect on patient satisfaction and the intention to use HIS    on regular bases.
Critical Assessment of An Economic Evaluation of a Healthy Lifestyle Intervention for Chronic Low Back Pain (LBP)
Authors: Balidemaj Festina
Published: December 2024

Background: Globally, chronic low back pain (LBP) contributes significantly to the overall burden of disease, placing a heavy load on society through absenteeism and associated healthcare costs. Finding cost-effective measures to treat and prevent low back pain is therefore of utmost importance. Methods: A critical assessment of the study by Williams et al 2018 was performed by using a variation of the well-known Drummond’s checklist for the critical appraisal of economic evaluations. Results: The authors performed appropriate statistical analyses using the available data. Means and proportions of baseline characteristics of the intervention group were compared to those of the control group to evaluate their comparability. Conclusion: Upon thorough assessment of the appropriateness of the economic evaluation methods used by Williams et al., it is conclusive that the validity of their results is valuable and trusted to a degree, soundly achieving many of the listed Drummond et al requirements, yet failing to take into account a few aspects that grant some weaknesses to the study.
Implementation of Intercropping on Independent Palm Oil Plantation Based on Financial Feasibility Study
Authors: Oktoriana Shenny , Hazriani Rini , Romiyanto Romiyanto
Published: December 2024

The smallholder palm oil plantations in the Mayasopa Subdistrict, Singkawang City, West Kalimantan, have an average productivity of around 1.25 tons per hectare per year. Despite this, the palm oil plantation areas in this subdistrict have seen significant growth, reaching 668 hectares, which accounts for approximately 50% of all palm oil plantations in East Singkawang District. Given this trend, it is imperative to enhance the economic well-being of palm oil farmers by introducing alternative technologies that would not only increase food security and farmer income but also contribute to environmental preservation through the adoption of intercropping patterns. This study is focused on analyzing the financial viability of various intercropping plants. The research methodology involved a descriptive survey among 34 farmers who have implemented different intercropping plants. The financial feasibility of each intercropping plant variant was evaluated using the B/C ratio and farming income as critical measures. The findings indicate that in sequence, chilies, taro, and corn meet the criteria for financial viability in intercropping implementation. Based on these results, it is recommended that palm oil farmers consider introducing intercropping on their plantations, with a particular emphasis on cultivating chilies, which has been identified as the most financially viable option, to enhance their economic prospects.
Features of ecology for bivalve mollusk Potamocorbula amurensis in Peter the Great Bay, Japan Sea
Authors: Kolpakov E. V. , Nemova D. D. , Sokolenko D. A.
Published: December 2024

Features of ecology are considered for euryhaline bivalve mollusk Potamocorbula amurensis dwelling in Peter the Great Bay. Spatial distribution of the species is not uniform, the mollusks settle mainly in the areas affected to the river discharge influence with water salinity from 5 to 30 ‰, in the uppermost layer of silty, silt-sandy, sandy, sandy-gravely, or sandy-gravel-pebbly soils at the depths from 0.3 to 7.0 m. The densest aggregations of P.amurensis are found in the top of Amur Bay, with the biomass up to 2.3 kg/m2 and abundance > 31.103 ind./m2 at the depths shallower 2.0 m. They are able to form a byssus thread up to 30 mm long. This sestonophag species occupies usually a dominant or subdominant position in benthic communities, and itself is a prey for asian paddle crab Charybdis japonica and seabirds. Larvae of P. amurensis could be transported by estuarine streams to estuaries and lagoons where the species forms temporary aggregations dependent on the parental stocks, but in the vast Razdolnaya River estuary, especially in the relatively deep Tavrichansky Liman, there are stable mixed-age settlements where the specimens of age 5+ can be found that is the maximum life span of P. amurensis for Peter the Great Bay.
On the physical origins of reduced ionic conductivity in nanoconfined electrolytes
Authors: Fong Kara D , Grey Clare P , Michaelides Angelos
Published: December 2024

Ion transport through nanoscale pores is at the heart of numerous energy storage and separation technologies. Despite significant efforts to uncover the complex interplay of ion-ion, ion-water, and ion-pore interactions that give rise to these transport processes, the atomistic mechanisms of ion motion in confined electrolytes remain poorly understood. In this work, we use machine learning-based molecular dynamics simulations to characterize ion transport with first principles-level accuracy in aqueous NaCl confined to graphene slit pores. We find that ionic conductivity decreases as the degree of confinement increases, a trend governed by changes in both ion self-diffusion and dynamic ion-ion correlations. We show that the self-diffusion coefficients of our confined ions are strongly influenced by the overall electrolyte density, which changes non-monotonically with slit height based on the layering of water molecules within the pore. We further observe a shift in the ions' diffusion mechanism towards more vehicular motion as the degree of confinement increases. Non-ideal (beyond Nernst-Einstein) contributions to transport become more prominent under confinement due to increased cation-anion correlations arising from long-lived contact ion pairs. By building a mechanistic understanding of confined electrolyte transport, this work provides insights that could guide the design of nanoporous materials optimized for efficient and selective ion transport.
CReM-dock: de novo design of synthetically feasible compounds guided by molecular docking
Authors: Minibaeva Guzel , Polishchuk Pavel
Published: December 2024

De novo generation of compounds is an attractive strategy allowing to explore much broader chemical space than virtual screening. Fragment-based approaches suffer from low synthetic accessibility of generated compounds. In this study we combined the previously developed fragment-based generator CReM and molecular docking to guide the exploration of chemical space. The developed approach is very flexible and allows to indirectly control synthetic accessibility of generated compounds, their diversity by choosing one of selection strategies, augmentation of an objective function to generate more drug-like compounds, control over preserving important protein-ligand interactions and ligand poses. The generated compounds demonstrated high novelty and were competitive to compounds generated with REINVENT4. We demonstrated in different case studies flexibility of the developed approach and its applicability to de novo generation as well as fragment expansion tasks.
Mapping Polyamine Interactions in Live Cells Through Photoaffinity Labeling
Authors: Zakrzewski Maciej , Cocom Benjamin , Rahman Firdaus Moh Egy , Kałek Marcin , Szczepanowska Karolina , Gerlach Piotr , Serwa Remigiusz Adam
Published: December 2024

Polyamines are essential metabolites that play a crucial role in regulating key cellular processes. While previous studies have shown that polyamines modulate protein function through non-covalent interactions, the lack of robust analytical methods has limited the systematic identification of these interactions in living cells. To address this challenge, we synthesized novel photoaffinity probes and applied them to a model cell line, identifying over 400 putative protein interactors with remarkable structure-dependent specificity. The interaction profiles of these probes were visualized through in-gel fluorescence scanning, and their subcellular localization was examined using fluorescence microscopy. Higher polyamine analogs predominantly target proteins in the nucleoplasm and cytosol, whereas diamine analogs localize to vesicle-like structures near the Golgi apparatus, implying that different polyamine types show a proclivity for specific cellular compartments. This study provides a comprehensive overview of polyamine-protein interactions in live cells, offering valuable insights into their roles in cellular processes.
Knowledge, Awareness and Practice of Interdental Aids among Dentists in Bangalore City - A Questionnaire Based Study
Authors: I Ajaishalu , Bose Aditi , Yadalam Umesh , Raghava K Vijay , K Nambiar Manjusha , S Prakash Nomitha
Published: December 2024

Background and Aim Dental plaque is key in periodontitis development making plaque control crucial for successful periodontal therapy. Brushing alone often falls short in removing all plaque highlighting the importance of interdental cleaning aids for maintaining good oral hygiene. While many studies have examined dental professionals oral health behaviours few have focused on their knowledge and use of interdental aids. Therefore this study was undertaken with the objective of assessing the knowledge attitude and practice of interdental aids among dentists in Bangalore city.Methods A questionnaire-based study was conducted involving 100 subjects comprising 24 male and 76 female dentists. Data collection was facilitated through an online Google form. The questionnaire comprised 15 questions with five questions each focusing on knowledge attitude and practice. Chi square test of independence was employed to examine the distribution of responses to all questions.Results The average knowledge scores for male and female dentists were 4.83plusmn0.483 and 4.51plusmn0.931 respectively. Similarly the mean attitude scores were 4.08plusmn1.1 and 3.29plusmn1.198 while the mean practice scores were 3.667plusmn1.37 and 3.355plusmn1.4 for male and female dentists respectively. Notably there was a statistically significant difference P 0.005 in attitude towards interdental aids between the two groups.Conclusion The investigation into oral hygiene aids among dentists unveiled a predominantly sound grasp and implementation of interdental aids despite the identification of knowledge gaps in specific areas. The practice regarding interdental aids should be improved. Dentists should adhere to recommended oral self-care practices and set an example for their patients.
Comparative study of predictive models for hoax and disinformation detection in indonesian news
Authors: Adiati Nadia Paramita Retno , Priambodo Dimas Febriyan , Girinoto Girinoto , Indarjani Santi , Rizal Akhmad , Prayoga Arga , Beatrix Yehezikha
Published: December 2024

Along with the times, false information easily spreads, including in Indonesia.  In Press Release No.485/HM/KOMINFO/12/2021 the Ministry of Communication and Information has cut off access to 565,449 negative content and published 1,773 clarifications on hoax and disinformation content. Research has been carried out regarding this matter, but it is necessary to classify fake news into disinformation and hoaxes. This study presents a comparison between our proposed model, which is an ensemble of shallow learning predictive models, namely Random Forest, Passive Aggressive Classifier, and Cosine Similarity, and the deep learning model that uses BERT-Indo for classification. Both models are trained using equivalent datasets, which contain 8757 news, consisting of 3000 valid news, 3000 hoax news, and 2757 disinformation news. These news were obtained from websites such as CNN, Kompas, Detik, Kominfo, Temanggung Mediacenter, Hoaxdb Aceh, Turnback Hoax, and Antara, which were then cleaned from all unnecessary substances, such as punctuation marks, numbers, Unicode, stopwords, and suffixes using the Sastrawi library. At the benchmarking stage, the shallow learning model is evaluated to increase accuracy by applying ensemble learning combined using hard voting.  This results in higher values, with an accuracy of 98.125%, precision of 98.2%, F-1 score of 98.1%, and recall of 98.1%, compared to the BERT-Indo model which only achieved 96.918% accuracy, 96.069% precision, 96.937% F-1 score, and 96.882% recall. Based on the accuracy value, shallow learning model is superior to deep learning model.  This machine learning model is expected to be used to combat the spread of hoaxes and disinformation in Indonesian news. Additionally, with this research, false news can be classified in more detail, both as hoaxes and disinformation
The role of clinical psychology in the military environment
Authors: Klymenko I.S.
Published: December 2024

Background. Clinical psychology is one of the main branches of psychology that specializes in studying and treating various mental disorders and issues, preventivemeasures for mental illnesses, diagnosis of diseases and pathological conditions, as well as the influence of psychocorrective methods on the recovery process [1–3]. Within the framework of clinical psychology, various mental health problems such as depression, anxiety, eating disorders, addiction, post-traumatic stress disorders, and others are considered and treated.

Purpose – to evaluate the role of clinical psychology in the military environment, clarify and emphasize the ethical aspects faced by clinical psychologists in the military sphere.

Materials and Methods. An analytical literature review was conducted, and based on the obtained data, a training course was developed for psychologists and practical psychologists of healthcare institutions with over 5 years of experience in the healthcare system, who were transferred to the position of «Clinical Psychologist», allowing to investigate the effectiveness of training and the necessity of this specialization, to examine the level of assistance provided to different samples worked with by practical psychologists in hospitals (military personnel, internally displaced persons), and the level of effectiveness of providing different levels of psychological assistance after specialization and implementation of the protocols developed by us. A random sampling method was used for the survey of the subjects. Research methods: systemic analysis, questionnaire survey, statistical analysis.

Results. It has been established that clinical psychologists often encounter ethical dilemmas arising from their dual identity as psychologists and military personnel, as well as from the unique context and mission of military service. This article provides a summary of unique aspects of clinical practice in the military sphere with a particular emphasis on those elements that exacerbate ethical challenges. Prior to providing psychological assistance and after the war-related trauma in Ukraine, psychologists conducted research on the levels of anxiety, depression, and stress among servicemen and veterans. The basic survey consisted of 21 questions assessing symptoms of depression, anxiety, and stress levels among servicemen and veterans. Various levels of depression were observed in 78.11 ± 2.58% of servicemen and veterans, while mild, moderate, and severe levels of stress were found in 84.07 ± 2.59% of individuals, and various levels of anxiety were present in 88.1 ± 2.48% of cases. After rehabilitation, the level of depression decreased by 24.21%, the level of stress by 25.07%, and the level of anxiety by 28.52%.

Conclusions. The obtained results justify the need to improve approaches to the training and retraining of psychologists and practical psychologists working in healthcare institutions with more than 5 years of experience in the healthcare system, who are transferred to the position of «Clinical Psychologist».