bluuebunny/crossref_metadata_2025 huggingface dataset:
Stock Market Prediction Using Machine Learning
Authors: Gaur Prof. Shailendra , Bhardwaj Rishabh , Bansal Vinay , Kumari Nidhi , Gupta Shalley
Published: May 2019

Stock price prediction is one of the most complex machine learning problems. It depends on a large number of factors which contribute to changes in the supply and demand. In this paper, we propose a stock prediction analysis using machine learning based on support vector machines (SVM), linear regression and reinforcement learning. SVM are favored in applications where text mining is used for market prediction. SVMs can be used for both linearly and non-linearly separable data sets. when the data is linearly separable, SVMs construct a hyperplane on the feature space to distinguish the training tuples in the data such that the margin between the support vectors is maximized. Correlation is used between stock prices of different companies to predict the price of a stock by using technical indicator of highly correlated stocks, not only stock to be predicted.
Kurang Energi Kronis pada Wanita Usia Subur di Wilayah Kecamatan Limboto Kabupaten Gorontalo
Authors: Paramata Yeni , Sandalayuk Marselia
Published: May 2019

Kekurangan Energi Kronik (KEK) adalah keadaan dimana remaja putri/wanita mengalami kekurangan gizi (kalori dan protein) yang berlangsung lama atau menahun. Pada tahun 2013 berdasarkan data riset kesehatan dasar prevalensi KEK di kabupaten Gorontalo sebesar 12,5% pada wanita usia 15-49 tahun yang sedang hamil dan 15,1% pada wanita usia 15-49 tahun yang tidak hamil. Untuk mencegah risiko KEK pada ibu hamil sebelum kehamilan, wanita usia subur (WUS) sudah harus mempunyai gizi yang baik, misalnya dengan LILA tidak kurang dari 23,5 cm. Berdasarkan permasalahan diatas penelitian ini bertujuan untuk mengambarkan kejadian kurang energi kronik pada wanita usia subur (15-49 tahun) di kecamatan Limboto Kabupaten Gorontalo. Penelitian ini dilaksanakan  di kelurahan Tilihuwa, dengan jumlah sampel sebanyak 162 WUS usia 15-49 tahun yang dipilih secara Accidental sampling. Penelitian ini merupakan studi deskriptif dengan pendekatan cross sectional. Hasil penelitian ini didapatkan bahwa kejadian KEK terbanyak pada kelompok Wanita Usia 15-24 tahun yaitu 13 orang (81,3%), tingkat pendidikan hanya tamatan SD yaitu 7 orang (43,8%), status pekerjaan sebagai Ibu Rumah Tangga saja yaitu 10 orang (62,5%) dan seluruhnya yang menderita KEK tidak sedang hamil yaitu 16 orang (100%). Untuk mengurangi risiko KEK pada Wanita Usia Subur agar lebih memperhatikan kesehatan dan konsumsi makanan bergizi terutama pada kelompok usia remaja.
Contribuições da monitoria acadêmica em urgência, emergência e terapia intensiva para enfermagem
Authors: Da Silva Ionara , Silva Joyce Carolynne , Lima Karen Rayara Bezerra , Dantas Daniele Vieira , Dantas Rodrigo Assis Neves , Ribeiro Maria do Carmo de Oliveira
Published: May 2019

Objetivo: Descrever a vivência durante a monitoria da disciplina de alta complexidade da graduação em Enfermagem, no cuidado ao paciente crí­tico atendido em emergência e terapia intensiva. Métodos: Trata-se de um estudo descritivo, do tipo relato de experiência, realizado no primeiro semestre de 2017 pelas monitoras do projeto de ensino intitulado "Inovando o processo de ensino-aprendizagem em Enfermagem na urgência e emergência e terapia intensiva", tendo como público-alvo discentes do sexto perí­odo do curso de graduação em Enfermagem. Resultados: O papel das monitoras foi, através da divisão da turma em trios, simular o Objective Structured Clinical Examination (OSCE) utilizando um caso clí­nico de Parada Cardiorrespiratória (PCR), e assim estimular os estudantes a praticar de forma realí­stica as manobras de reanimação cardiopulmonar, além de utilizar o raciocí­nio clí­nico e julgamento crí­tico para definir a possí­vel causa da parada, bem como os cuidados pós-reanimação. Conclusão: A experiência da monitoria é de suma importância na formação acadêmica, pois, ao passo em que utiliza metodologias ativas com a finalidade de garantir melhorias no processo de ensino e aprendizagem dos alunos, o monitor também obtém extensa carga de conhecimentos na área e torna-se sujeito ativo no processo de iniciação í  docência.Palavras-chave: ensino, estudantes de enfermagem, reanimação cardiopulmonar, cuidados crí­ticos.
Prevenção de lesão por pressão e o uso do colchão pneumático versus colchão piramidal em unidade de terapia intensiva
Authors: Pereira Alexandre Aguiar , Pereira Ana Paula Aguiar , De Miranda Andrea Fabiane Aguiar Chagas , Rodrigues Elaine Valéria , Guimarães Jaqueline Vieira , Rassy Maria Elizabete de Castro
Published: May 2019

Introdução: As lesões por pressão são injúrias na pele ou tecidos moles adjacentes, que normalmente encontram-se sobre uma proeminência óssea, consideradas como problema de saúde pública e fator de agravo para o paciente acamado. Objetivo: Relatar o caso de pacientes que utilizaram o colchão pneumático e/ou piramidal como estratégia de prevenção de lesões por pressão em Unidade de Terapia Intensiva. Métodos: Relato de caso, descritivo, realizado em uma Unidade de Terapia Intensiva Adulto de uma Maternidade de Referência na cidade de Belém/PA, em setembro de 2017, com 6 pacientes. Para a obtenção dos dados foi realizada a busca dos pacientes que utilizavam o colchão pneumático e/ou piramidal e anotações diárias de enfermagem. Resultados: Dois (33,3%) dos pacientes que foram colocados sob o uso de colchão piramidal apresentaram lesão por pressão, enquanto dos 4 (66,67%) que utilizaram o colchão pneumático, apenas 1 (16,67%) paciente apresentou lesão. Conclusão: Sendo a prevenção de lesão por pressão uma das metas de Segurança do Paciente, concluiu-se que a utilização do colchão pneumático poderá contribuir para a redução do aparecimento dessas lesões em Unidade de Terapia Intensiva.Palavras-chave: lesão por pressão, unidades de terapia intensiva, segurança do paciente.
As representações sociais de Iemanjá para seus devotos: apontamentos para o cuidado de Enfermagem
Authors: Barbosa Bruno Ferreira do Serrado , Gomes Antônio Marcos Tosoli , Mercês Magno Conceição das , Duarte Gilmar Junker , França Luiz Carlos Moraes , Brandão Juliana de Lima , Reis Eudaci da Silva
Published: May 2019

Objetivo: Identificar a estrutura das representações sociais de Iemanjá na Cidade de Salvador para os frequentadores de sua festa e analisar estas representações sociais como base para o planejamento e a implementação do cuidado de enfermagem, em especial com relação ao conforto na relação enfermeiro-paciente. Métodos: No contexto da psicologia social o presente configura-se como estudo descritivo com abordagem qualitativa, alicerçado na teoria do núcleo central das representações sociais, neste estudo sobre a representação de Iemanjá. O campo da pesquisa foi a cidade de Salvador, Bahia, durante os festejos de Iemanjá, onde 99 pessoas com idade superior a 18 anos participaram. Resultados: O grupo estudado compreendia devotos, fiéis ou simpatizantes de Iemanjá e outras pessoas que estavam no local sem explicação definida e/ou trabalhavam na festa. O núcleo central das representações sobre Iemanjá é constituí­do por conteúdos que remetem três dimensões: prática, transcendental e afetiva. Conclusão: A estrutura representacional de Iemanjá entre os participantes do estudo apresenta vertentes práticas, imagéticas e transcendentais, que se estabelecem a partir de um processo dialógico-psico-contextual e os elementos que envolvem a entidade Iemanjá, principalmente a fé, pode ser imprescindí­vel para vinculação, compreensão e participação do paciente em dinâmicas assistências de Enfermagem.Palavras-chave: religião, enfermagem, espiritualidade.
Archives Management and Permanent Storage of Documents
Authors: Berisha Fikrie
Published: May 2019

Modern digital archives are modern archives which in big computer devices (servers), preserve archived original document overlooking the moment is produced. Archives in Kosovo assessment of archival documents make in two directions. First; selection of classical documents (on paper) with the value to be transformed into digital documents, and second; selection of contemporary documents produced by institutions of computer and internet era. Management of these digital documents requires procedures and professional standards for its storage and processing by the archive, in order to be ready to serve researchers and interested parties. Access to digital documents should be fast, simple procedures, providing documentation from the penetration of ‘hackers’ and people badly intention. To fulfil its mission digital document should ensure and complement the appearance of the original document. Since the user does not have the option of intervention and change in the document. Should work in protect emblem, which protects the entire area of the document in the form of molten seal, which also shows the ownership of certain archive. Safety documentation and document base by external users will be able to organize, deposit and stored at three levels: Server (1) be stored (saved) archival documents for use by the applicant; Server (2) stored data of the first and simultaneously updates added by continuous processing of new documents; and Server (3) is not accessible from outside through digital network, but stored all digital archive documentation and from here there should be no often exit. In Server 3 only entered document and stored as recent bank. From there, the document will be drawn only if it is missing or damaged document on server 1 and 2.Thus, through this categorization could be provided for long time electronic documents (digital), until to new modern inventions of modern digitalization technology that would ensure the preservation of documents for the ‘real’ long-term or permanent time.
Electronic Records Management in Romania: More Electronic-, Less Records-Management
Authors: Popovici Bogdan-Florin
Published: May 2019

The management of electronic records and documents seems to be very developed in Romania. Mostly under UE financing, a lot of institutions implemented modern systems and digitized legacy paper records. Pertinent pieces of legislation were adopted (time-stamp, electronic signature and even an electronic archiving act) and this might create an image of proper regulated environment. But a closer look to the facts shows that proper electronic records management lacks almost completely. The paper will look into details about the way modern archives are prepared for the future.
Disabled Persons in Slovenian Archives Reading Rooms: the Problem of Accessibility
Authors: Kosi Mojca
Published: May 2019

Article 14 of the Constitution of the Republic of Slovenia (1991) quotes: “In the Republic of Slovenia everyone is granted the same human and universal rights regardless of nationality, race, gender, language, religion, political beliefs, education, social status, disability or any other personal circumstance”. Reality isn’t always like that and with my paper I would like to point out a group of people that encounters various problems when executing their right of free movement (access to public spaces) and their right to retrieve, receive and spread information (access to- and usage of archives). When building or reconstructing Archives we shouldn’t think only about how to protect archival material but also about how to enable people with disabilities to move freely inside of premises and access archives.
Importance of Cultural and Educational Activities for Openness and Affirmation of Archives in Society (Experiences of the Archive of Tuzla Canton)
Authors: Zulić Omer
Published: May 2019

Cultural and educational activities are an important and indispensable segment of each archive. The same is manifested through various forms of action of exhibitions, cooperation with the media and educational institutions. We are talking about various facilities and projects that have multiple goals. One is presentation and affirmation of archival material as cultural heritage, as well as archives and archival activities. The second is the involvement of citizens, especially young people (students) in the project activities, thus raising awareness of the importance of the written cultural heritage. Opening the archives for citizens and society, through cultural and educational and other facilities at the time of global trends in the world, it certainly top priority. In this sense, the overall results are reflected in the level of affirmation, and (lack of) opennes of archives to society. Therefore, this paper aims to highlight the importance of cultural and educational activities, through the experience of the Archives of Tuzla Canton, for affirmation and greater openness of our Archives to professional, scientific, cultural, and the general public.
All with one Aim in Mind: Cooperation at Federal Level in the Field of Digital Archiving
Authors: Kruse Christian
Published: May 2019

Archives throughout the world are faced with the enormous task of ensuring that digital documents are permanently legible in order to be able to archive them. The possibilities of an individual archive administration in terms of human resources and finances are quickly exceeded on the way to a solution. The contribution presents cooperation at federal level, the joint efforts undertaken and the result.
Swiss Competency Model for the Archivist of the 21st Century
Authors: Bianchi Cristina
Published: May 2019

The paper discusses the competency model for archivists that the Swiss Association of Archivists (AAS) has written and published in 2012 to create a common model for all the parts of Switzerland including its different German, Italian and French traditions. The goal was to define the profession at the Swiss level, including its new aspects, and also communicate a positive picture of the profession, which remains mainly unknown outside specialized circles. Challenges between different linguistic traditions, new requirements of the professions, and a threefold set of competencies are explained through examples given in French and German, and translated into English, in the AAS documents Les métiers des archives: Le profil professionnel des archivistes (Profession in Archives : Competency Model of the Archivist) and Archiviste: un métier (Archivist : A Profession). Archival activities require specialized knowledge, professional competencies and social competencies, a new area for the first time taken into account and officially recognized.
The Relationship Between Private and Public Archive: Theory and Practice
Authors: Bogosavljević Mirjana
Published: May 2019

Clearly and precisely defined laws represent the basis for a good attitude towards the arhival materials, legal regulations determine the procedures and to a large extent make it possible to achieve a high level of protection and security of documents both in public archives and in private ones. The key problem is the issue of the normative arrangement of archival documents in private ownership. How is the document stored with the owner, how does the archive come to a contact, and if there is any legal regulation regarding the acquiring of documents from a private archive? The fact is that documents are archive treasures whether they are in the public archives or in private ownership. It is therefore important to establish a normative framework that encompasses a series of laws that are dealing with the profession, but above all taking care of the protection of documents and their preservation. The basis of work is the question of the relationship between state and private archives and their linkage as well as the usefulness of existing laws in the direction of taking over and keeping private property in possession of state archives.
Hyaluronidase-Responsive Mesoporous Silica Nanoparticles with Dual-Imaging and Dual-Target Function
Authors: Wu Zhi-Yuan , Lee Cheng-Chang , Lin Hsiu-Mei
Published: May 2019

Nanoparticle-based drug delivery systems are among the most popular research topics in recent years. Compared with traditional drug carriers, mesoporous silica nanoparticles (MSN) offer modifiable surfaces, adjustable pore sizes and good biocompatibility. Nanoparticle-based drug delivery systems have become a research direction for many scientists. With the active target factionalized, scientists could deliver drug carriers into cancer cells successfully. However, drugs in cancer cells could elicit drug resistance and induce cell exocytosis. Thus, the drug cannot be delivered to its pharmacological location, such as the nucleus. Therefore, binding the cell membrane and the nuclear target on the nanomaterial so that the anticancer drug can be delivered to its pharmacological action site is our goal. In this study, MSN-EuGd was synthesized by doping Eu3+ and Gd3+ during the synthesis of MSN. The surface of the material was then connected to the TAT peptide as the nucleus target for targeting the cancer nucleus and then loaded with the anticancer drug camptothecin (CPT). Then, the surface of MSN-EuGd was bonded to the hyaluronic acid as an active target and gatekeeper. With this system, it is possible and desirable to achieve dual imaging and dual targeting, as well as to deliver drugs to the cell nucleus under a hyaluronidase-controlled release. The experimental approach is divided into three parts. First, we conferred the material with fluorescent and magnetic dual-imaging property by doping Eu3+ and Gd3+ into the MSN. Second, modification of the cell membrane target molecule and the nucleus target molecule occurred on the surface of the nanoparticle, making the nanoparticle a target drug carrier. Third, the loading of drug molecules into the carrier gave the entire carrier a specific target profile and enabled the ability to treat cancer. In this study, we investigated the basic properties of the drug carrier, including physical properties, chemical properties, and in vitro tests. The result showed that we have successfully designed a drug delivery system that recognizes normal cells and cancer cells and has good anticancer effects.
Impact of Different Gums on Textural and Microbial Properties of Goat Milk Yogurts during Refrigerated Storage
Authors: Park Young , Oglesby Jolethia , Hayek Saeed , Aljaloud Sulaiman , Gyawali Rabin , Ibrahim Salam
Published: May 2019

In this study, the impact of seven different gums on textural and microbiological properties of goat milk yogurt during refrigerated storage was investigated. The results showed that yogurt containing xanthan and locust bean gums had enhanced firmness, consistency, cohesiveness, and viscosity during four weeks of storage compared to the control and yogurt fortified with other gums (p < 0.05). The addition of gums also helped to maintain the microbial viability of the yogurt culture and the probiotic Bifidobacterium spp. This study thus demonstrated that these gums could be used in the production of goat milk yogurt with enhanced textural properties.
Anti-Obesity Effect of Extract from Nelumbo Nucifera L., Morus Alba L., and Raphanus Sativus Mixture in 3T3-L1 Adipocytes and C57BL/6J Obese Mice
Authors: Sim Wan-Sup , Choi Sun-Il , Cho Bong-Yeon , Choi Seung-Hyun , Han Xionggao , Cho Hyun-Duk , Kim Seung-Hyung , Lee Boo-Yong , Kang Il-Jun , Cho Ju-Hyun , Lee Ok-Hwan
Published: May 2019

The antioxidant and anti-adipogenic activities of a mixture of Nelumbo nucifera L., Morus alba L., and Raphanus sativus were investigated and their anti-obesity activities were established in vitro and in vivo. Among the 26 different mixtures of extraction solvent and mixture ratios, ethanol extract mixture no. 1 (EM01) showed the highest antioxidant (α,α-Diphenyl-β-picrylhydrazyl, total phenolic contents) and anti-adipogenic (Oil-Red O staining) activities. EM01 inhibited lipid accumulation in 3T3-L1 adipocytes compared to quercetin-3-O-glucuronide. Furthermore, body, liver, and adipose tissue weights decreased in the high-fat diet (HFD)-EM01 group compared to in the high-fat diet control group (HFD-CTL). EM01 lowered blood glucose levels elevated by the HFD. Lipid profiles were improved following EM01 treatment. Serum adiponectin significantly increased, while leptin, insulin growth factor-1, non-esterified fatty acid, and glucose significantly decreased in the HFD-EM01 group. Adipogenesis and lipogenesis-related genes were suppressed, while fat oxidation-related genes increased following EM01 administration. Thus, EM01 may be a natural anti-obesity agent.
Modeling the Potential of Submarine Groundwater Discharge to Facilitate Growth of Vibrio cholerae Bacteria
Authors: Vollberg Felix , Walther Marc , Gärdes Astrid , Moosdorf Nils
Published: May 2019

Submarine groundwater discharge (SGD), the discharge of terrestrial groundwater to the ocean, can govern the coastal benthic environment. Bacteria such as Vibrio cholerae inhabit coastal waters and sediments, whose growth can be influenced by SGD. In particular, salinity changes introduced by SGD could have a positive effect on the abundance but also virulence of non-halophilic V. cholera bacteria dwelling in coastal waters and shallow marine sediments. Here we assess potential effects of SGD on the environmental properties that favor V. cholerae in a numerical modeling study representing multiple scenarios. Approaching natural systems, simulation results reveal a high sensitivity of non-halophilic Vibrio cholerae growth to SGD and its primary driving factors. This dependency leads to highest growth potential at high groundwater inflow and low hydraulic conductivity of the aquifer as well as for steep sea-side boundary slopes. Besides its minor impact on the extent of SGD in our model, dispersion is a crucial limiting factor for V. cholerae habitat. We conclude that there is a close connection between the driving factors of SGD and low salinity zones along a coastal slope, and recommend taking these into consideration for evaluating local V. cholerae outbreaks.
On (G, G′)-Prešić–Ćirić Operators in Graphical Metric Spaces
Authors: Shukla Satish , Mlaiki Nabil , Aydi Hassen
Published: May 2019

The purpose of this paper is to introduce a new type of operators in graphical metric spaces and to prove some fixed point results for these operators. Several known results are generalized and extended in this new setting of graphical metric spaces. The results are illustrated and justified with examples.
Relevant Aspects of Clostridium estertheticum as a Specific Spoilage Organism of Vacuum-Packed Meat
Authors: Wambui Joseph , Stephan Roger
Published: May 2019

Clostridium estertheticum is a psychrotolerant, gram-positive, motile, anaerobic, spore-forming, rod-shaped bacteria that causes blown pack spoilage (BPS). Spoilage occurs in vacuum-packed meat without temperature abuse. Having been reported in the last 30 years in several countries, BPS by Cl. estertheticum is a major issue around the world and presents a huge economic impact on the meat industry. Despite being an important spoilage microorganism, studies on Cl. estertheticum are challenged by numerous aspects. These include, lack or poor growth in laboratory media, long culturing periods, and unpredictable isolation on the media. These factors hamper the detection of Cl. estertheticum before occurrence of BPS, which further undermines efforts to prevent the occurrence of BPS. Nevertheless, considerable developments have taken place with regard to culture-independent methods. Although information on Cl. estertheticum is available, it is limited and remains highly fragmented. Therefore, this review collates the available information and discusses relevant aspects of Cl. estertheticum as a specific spoilage organism of BPS in vacuum-packed meat.
Lamium Plants—A Comprehensive Review on Health Benefits and Biological Activities
Authors: Salehi Bahare , Armstrong Lorene , Rescigno Antonio , Yeskaliyeva Balakyz , Seitimova Gulnaz , Beyatli Ahmet , Sharmeen Jugreet , Mahomoodally Mohamad Fawzi , Sharopov Farukh , Durazzo Alessandra , Lucarini Massimo , Santini Antonello , Abenavoli Ludovico , Capasso Raffaele , Sharifi-Rad Javad
Published: May 2019

This work is an updated snapshot of Lamium plants and their biological activities. The main features of the plant are described and the components of its essential oils are summarized. The traditional medicinal uses of Lamium plants has been reported. The presence of these chemicals i.e., hydroxycinnamic acids, iridoids, secoiridoids, flavonoids, anthocyanins, phenylpropanoids, phytoecdysteroids, benzoxazinoids, betaine can provide biological activities. After the discussion of antioxidant properties documented for Lamium plants, the biological activities, studied using in vitro models, antimicrobial, antiviral, anti-inflammatory, anti-nociceptive activity, and pain therapy and cytotoxicity and cytoprotective activity are here described and discussed. Finally, targeted examples of in vivo studies are reported.
Carbon Dot-Mediated Capillary Electrophoresis Separations of Metallated and Demetallated Forms of Transferrin Protein
Authors: Sirkisoon Leona R. , Makamba Honest C. , Saito Shingo , Colyer Christa L.
Published: May 2019

Carbon dots (CDs) are fluorescent nanomaterials used extensively in bioimaging, biosensing and biomedicine. This is due in large part to their biocompatibility, photostability, lower toxicity, and lower cost, compared to inorganic quantum dots or organic dyes. However, little is known about the utility of CDs as separation adjuvants in capillary electrophoresis (CE) separations. CDs were synthesized in-house according to a ‘bottom-up’ method from citric acid or other simple carbon precursors. To demonstrate the applicability of CDs as separation adjuvants, mixtures of holo- (metallated) and apo- (demetallated) forms of transferrin (Tf, an iron transport protein) were analyzed. In the absence of CDs, the proteins were not resolved by a simple CE method; however, upon addition of CDs to the separation buffer, multiple forms of Tf were resolved indicating that CDs are valuable tools to facilitate the separation of analytes by CE. CE parameters including sample preparation, buffer identity, ionic strength, pH, capillary inside diameter, and temperature were optimized. The results suggest that dots synthesized from citric acid provide the best resolution of various different forms of Tf and that CDs are versatile and promising tools to improve current electrophoretic separation methods, especially for metalloprotein analysis.
Constituents Isolated from the Leaves of Glycyrrhiza uralansis and Their Anti-Inflammatory Activities on LPS-Induced RAW264.7 Cells
Authors: Wang Liyao , Zhang Kaixue , Han Shu , Zhang Liu , Bai Haiying , Bao Fang , Zeng Yan , Wang Jiyong , Du Hong , Liu Yingqian , Yang Zhigang
Published: May 2019

Licorice, the root and rhizome of Glycyrrhiza uralansis Fisch, is one of the most frequently used Traditional Chinese Medicines in rigorous clinical trials to remove toxins and sputum, and to relieve coughing. However, the aerial parts are not used so widely at present. It has been reported that the aerial parts have many bioactivities such as anti-microbial and anti-HIV activities. In this study, we aimed to discover the bioactive compounds from the leaves of G. uralensis. Four new compounds, licostilbene A-B (1–2) and licofuranol A-B (3–4), together with eight known flavonoids (5–12), were isolated and identified from the leaves of G. uralensis. Their structures were elucidated mainly by the interpretation of high-resolution electrospray mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) spectroscopic data. Compared with quercetin, which showed a 50% inhibitory concentration (IC50) value of 4.08 μg/mL, compounds 1–9 showed significant anti-inflammatory activities by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 2.60, 2.15, 3.21, 3.25, 2.00, 3.45, 2.53, 3.13 and 3.17 μg/mL, respectively. The discovery of these active compounds is important for the prevention and treatment of inflammation.
Norcantharidin Suppresses YD-15 Cell Invasion Through Inhibition of FAK/Paxillin and F-Actin Reorganization
Authors: Hong Kyoung-Ok , Ahn Chi-Hyun , Yang In-Hyoung , Han Jung-Min , Shin Ji-Ae , Cho Sung-Dae , Hong Seong Doo
Published: May 2019

Norcantharidin (NCTD), a demethylated derivative of cantharidin, has been reported to exhibit activity against various types of cancers. However, the anti-invasive effects of NCTD and its molecular mechanism in human mucoepidermoid carcinoma (MEC) remain incompletely elucidated. Clonogenic, wound healing, invasion, zymography, western blotting and immunocytochemistry assays were performed in YD-15 cells to investigate the anti-invasive effect of NCTD and its molecular mechanism of action. The inhibitory effects of NCTD on invasiveness were compared with those of a novel focal adhesion kinase (FAK) kinase inhibitor, PF-562271. NCTD markedly suppressed the colony formation, migration, and invasion of YD-15 cells as well as the activities of MMP-2 and MMP-9. It disrupted F-actin reorganization through suppressing the FAK/Paxillin axis. Moreover, NCTD exhibited a powerful anti-invasive effect compared with that of PF-562271 in YD-15 cells. Collectively, these results suggest that NCTD has a potential anti-invasive activity against YD-15 cells. This study may clarify the impact of NCTD on migration and invasion of human MEC cells.
Application of GC/MS-Based Metabonomic Profiling in Studying the Therapeutic Effects of Aconitum carmichaeli with Ampelopsis japonica Extract on Collagen-Induced Arthritis in Rats
Authors: Jin Hua , Ma Ningning , Li Xin , Kang Mingqin , Guo Maojuan , Song Lili
Published: May 2019

Aconitum carmichaeli with Ampelopsis japonica (AA) is a classical traditional Chinese medicine (TCM) formula. There are a lot of examples showing that AA can be used to treat rheumatoid arthritis, but its mechanism of action is still not completely clear. In this research, collagen-induced arthritis (CIA) was chosen as a rheumatoid arthritis (RA) model. Rats of treated groups were continuously administered Aconitum carmichaeli (AC), Ampelopsis japonica (AJ) and Aconitum carmichaeli + Ampelopsis japonica (AA) orally once a day from the day after the onset of arthritis (day 7) until day 42. The results showed that AA not only significantly reduced paw swelling, but also improved the levels of TNF-α and IL-6 in serum. GC-MS-based urine metabonomics was established to analysis metabolic profiles and 21 biomarkers of RA rats were identified by the Partial Least Squares Discriminant Analysis (PLS-DA) and Support Vector Machine (SVM) methods. The prediction rate of the SVM method for the 21 biomarkers was 100%. Twenty of 21 biomarkers, including D-galactose, inositol and glycerol, gradually returned to normal levels after administration of AA. Metabolomic Pathway Analysis (MetPA) generated three related metabolic pathways—galactose metabolism, glycerolipid metabolism and inositol phosphate metabolism—which explain the mechanism of AA treatment of rheumatoid arthritis. This research provides a better understanding of the therapeutic effects and possible therapeutic mechanism of action of a complex TCM (AA) on rheumatoid arthritis.
The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules
Authors: Zhong Yanwen , Li Xuanyi , Yao Hequan , Lin Kejiang
Published: May 2019

The programmed cell death ligand protein 1 (PD-L1) is a member of the B7 protein family and consists of 290 amino acid residues. The blockade of the PD-1/PD-L1 immune checkpoint pathway is effective in tumor treatment. Results: Two pharmacophore models were generated based on peptides and small molecules. Hypo 1A consists of one hydrogen bond donor, one hydrogen bond acceptor, two hydrophobic points and one aromatic ring point. Hypo 1B consists of one hydrogen bond donor, three hydrophobic points and one positive ionizable point. Conclusions: The pharmacophore model consisting of a hydrogen bond donor, hydrophobic points and a positive ionizable point may be helpful for designing small-molecule inhibitors targeting PD-L1.
Relationship Between G-Quadruplex Sequence Composition in Viruses and Their Hosts
Authors: Puig Lombardi Emilia Puig , Londoño-Vallejo Arturo , Nicolas Alain
Published: May 2019

A subset of guanine-rich nucleic acid sequences has the potential to fold into G-quadruplex (G4) secondary structures, which are functionally important for several biological processes, including genome stability and regulation of gene expression. Putative quadruplex sequences (PQSs) G3+N1–7G3+N1–7G3+N1–7G3+ are widely found in eukaryotic and prokaryotic genomes, but the base composition of the N1-7 loops is biased across species. Since the viruses partially hijack their hosts’ cellular machinery for proliferation, we examined the PQS motif size, loop length, and nucleotide compositions of 7370 viral genome assemblies and compared viral and host PQS motifs. We studied seven viral taxa infecting five distant eukaryotic hosts and created a resource providing a comprehensive view of the viral quadruplex motifs. Overall, short-looped PQSs are predominant and with a similar composition across viral taxonomic groups, albeit subtle trends emerge upon classification by hosts. Specifically, there is a higher frequency of pyrimidine loops in viruses infecting animals irrespective of the viruses’ genome type. This observation is confirmed by an in-depth analysis of the Herpesviridae family of viruses, which showed a distinctive accumulation of thermally stable C-looped quadruplexes in viruses infecting high-order vertebrates. The occurrence of viral C-looped G4s, which carry binding sites for host transcription factors, as well as the high prevalence of viral TTA-looped G4s, which are identical to vertebrate telomeric motifs, provide concrete examples of how PQSs may help viruses impinge upon, and benefit from, host functions. More generally, these observations suggest a co-evolution of virus and host PQSs, thus underscoring the potential functional significance of G4s.
Preparing Pharmacists for Collaborative/Integrated Health Settings
Authors: Ascione Frank J.
Published: May 2019

Pharmacy practice is changing to accommodate the need for pharmacists to be better team members in newly emerging collaborative care and integrated health systems. Pharmacy schools could lead this change by educating students to be effective participants in these relatively new models of care. Schools are encouraged to follow the approach outlined in the recent guidance published by the Health Professions Accreditors Collaborative (HPAC) for interprofessional practice and education (“the new IPE”). This approach includes articulating an IPE plan, establishing goals, assessing student achievement of the necessary IPE competencies, developing educational plans that are multi-faceted and longitudinal, and modifying the existing assessment/evaluation process to ensure the quality of the IPE effort. These curricular decisions should be based on existing and new research on the effectiveness of IPE on student’s attitudes, knowledge, skills, and behavior. A key decision is how to create effective interactions between pharmacy students and those of other professions. Educational emphasis should be directed toward team building skills, not just individual competencies. The pharmacy faculty probably need to enhance their teaching abilities to accommodate this change, such as learning new technology (e.g., simulations, managing online exchanges) and demonstrating a willingness to teach students from other professions.
Correlation of Heavy and Light Flavors in Simulations
Authors: Frajna Eszter , Vértesi Róbert
Published: May 2019

The ALICE experiment at the Large Hadron Collider (LHC) ring is designed to study the strongly interacting matter at extreme energy densities created in high-energy heavy-ion collisions. In this paper we investigate correlations of heavy and light flavors in simulations at LHC energies at mid-rapidity, with the primary purpose of proposing experimental applications of these methods. Our studies have shown that investigating the correlation images can aid the experimental separation of heavy quarks and help understanding the physics that create them. The shape of the correlation peaks can be used to separate the electrons stemming from b quarks. This could be a method of identification that, combined with identification in silicon vertex detectors, may provide much better sample purity for examining the secondary vertex shift. Based on a correlation picture it is also possible to distinguish between prompt and late contributions to D meson yields.
Desgaste dental y hábitos dietarios en poblaciones arqueológicas del centro de Argentina
Authors: González Claudina V. , Fabra Mariana
Published: May 2019

El objetivo del presente trabajo es aportar al conocimiento sobre las estrategias de subsistencia y dieta de las poblaciones que habitaron el centro de Argentina, particularmente el actual territorio de la provincia de Córdoba en el Holoceno tardío, a partir del análisis macroscópico del patrón y el grado de desgaste dental. La muestra analizada está compuesta por 61 individuos adultos (19 femeninos y 42 masculinos) que provienen de 36 sitios arqueológicos de dos regiones geográficas, denominadas Sierras y Llanuras. Se cuenta con información radiocarbónica para 52 individuos, que permite ubicarlos en un rango entre los 4058 ± 89 y los 370 ± 15 14C años AP. Se registró de forma macroscópica el grado, patrón y forma del desgaste dental sobre 1.021 piezas dentales y luego se calcularon prevalencias según el sexo, la edad de muerte, la región (Sierras y Llanuras) y el período cronológico (previo a 1200 años AP, posterior a 1200 años AP). Se aplicaron análisis estadísticos (Chi-cuadrado) para evaluar la significación estadística de las diferencias observadas. Los resultados indican la existencia de diferencias regionales y temporales, tanto en la forma como en el grado del desgaste dental de estas poblaciones. Consideramos que estas diferencias estarían relacionadas a diferentes formas y técnicas de preparación de los alimentos antes que a cambios dietarios.
The threats of wire and wireless data transmission systems in rail traffic and management systems including cyber and terroristic attacks
Authors: Lewiński Andrzej
Published: May 2019

The paper deals with presentation of up to date state of protection in dissipated, computer railway control and management systems, including the future systems implemented in Polish State Railways based on wireless standards with regard the ETMS/ETCS solutions.
PELATIHAN DAN PENDAMPINGAN PEMBUATAN MEDIA PEMBELAJARAN BERBANTU MACROMEDIA FLASH BAGI GURU SMPN 11 TARAKAN SEBAGAI SALAH SATU UPAYA PENINGKATAN INOVASI DALAM PEMBELAJARAN
Authors: Rahayu Setia Widia , Widyawati Eka
Published: May 2019

Kondisi di lapangan bahwa masih banyak ditemukan guru yang dalam penyampaiannya hanya berceramah danduduk di depan kelas. Hal tersebut terjadi karena kurangnya kemampuan guru dalam memahami makna,manfaat dan cara penggunaan media pembelajaran. Melihat kondisi seperti itu, maka saya sebagai ketua timpengabdian memiliki inisiatif untuk membantu guru-guru disekolah dalam menciptakan media pembelajaran.Penggunaan media dalam proses pembelajaran diharapkan akan memudahkan siswa untuk memahami apayang disampaikan oleh guru, selain itu dengan menggunakan media pembelajaran akan memudahkan gurudalam menyampaikan materi pembelajaran dikelas. Adapun kegiatan pengabdian ini berupa pelatihan danpendampingan yang dilakukan dalam bentuk klasikal dan kelompok. Pelatihan pembuatan media pembelajaranmacromedia flash, berupa demonstrasi pelatihan pembuatan media pembelajaran, unjuk kerja kemampuanguru-guru SMPN 11 Tarakan dalam membuat media pembelajaran dan dan pendampingan perkembanganpelaksanaan program dari mampu menghasilkan media pembelajaran interaktif dan menarik. Kegiatanpengabdian pada masyarakat di SMPN 11 ini dirasakan sangat membantu guru-guru SMPN 11 Tarakan, halitu dilihat dari wawancara dan respon yang diberikan kepada peserta. Hasil pelatihan ini adalah guru pahamcara membuat media pembelajaran dengan bantuan macromedia flash.
Morphology, molecular genetics, and acoustics reveal two new species of the genus Leptobrachella from northwestern Guizhou Province, China (Anura, Megophryidae)
Authors: Wang Jian , Li Yu-Long , Li Yao , Chen Hong-Hui , Zeng Ya-Jun , Shen Jing-Min , Wang Ying-Yong
Published: May 2019

Two new species of the genusLeptobrachellaSmith, 1925,L.bijieJ. Wang, Y.L. Li, Y. Li, H.H. Chen & Y.Y. Wang,sp. nov.andL.purpuraventraJ. Wang, Y.L. Li, Y. Li, H.H. Chen & Y.Y. Wang,sp. nov., were described from northwestern Guizhou Province, China based on a combination of acoustic, molecular, and morphological data. The new discoveries bring the total number of this genus to 73, with 16 congeners recorded in China, and represent the second and third species of the genus reported from Guizhou Province.
Hattin y Alarcos: un análisis comparativo de la respuesta institucional de las órdenes militares a graves crisis en el este latino y la península ibérica
Authors: Bronstein Judith
Published: May 2019

Este artículo compara las respuestas de los Hospitalarios en el Reino de Jerusalén al desastroso resultado de la batalla de Hattin y de la orden de Calatrava en el Reino de Castilla a la batalla de Alarcos. Comparar el impacto de batallas devastadoras en estas dos órdenes militares facilita el análisis de factores inter-institucionales y extra-institucionales, como los modelos institucionales y las relaciones con la monarquía, que influyeron en la capacidad de las órdenes para recuperarse de estas crisis. El artículo utiliza una variedad de fuentes primarias de los siglos XII y XIII pertenecientes a órdenes militares, como cartas y fuentes legislativas, y también cartas, bulas papales y fuentes narrativas del este latino y la península ibérica.
Escenificaciones de poder en el ceremonial de las aperturas de Cortes españolas del siglo XIX
Authors: Luján Oriol
Published: May 2019

Este texto tiene la voluntad de analizar los ceremoniales de las aperturas de Cortes españolas de los primeros tres cuartos del siglo XIX (1810- 1874), como actos simbólicos de representación del poder. En estas páginas, se examinan las principales características del ritual, así como el papel de los sujetos participantes. Fundamentado en una metodología multidisciplinar, el estudio combina la influencia de la comunicación simbólica y el análisis de los conceptos utilizados en los discursos de apertura. El resultado pone de relieve la voluntad de la monarquía para presentarse como nexo de unión entre las instituciones parlamentarias y la población, conservando la Corona una posición autónoma. A pesar de que el ceremonial consolidó el papel central de la Corona, hay que destacar que también sirvió a los gobiernos como instrumento de control político y, en última instancia, ayudó a asentar el parlamentarismo.
Juan Donoso Cortés y Atanazy Raczyński: historia y consecuencias de su amistad
Authors: Mencfel Michał
Published: May 2019

El objeto del presente ensayo es mostrar la historia de la amistad entablada entre Atanazy Raczyński, aristócrata polaco y diplomático prusiano, y Juan Donoso Cortés, político, diplomático y pensador español. Para ello se indican las circunstancias de su encuentro en otoño de 1848 en Madrid y el rápido desarrollo de su relación, que, no obstante, tuvo un comienzo desafortunado y estuvo rodeado de prejuicios iniciales. La idea que aquí se desarrolla es que el fundamento de su amistad, a pesar de la divergencia de caracteres, se basaba en la coincidencia de sus ideas políticas. Dado que el pensamiento de Raczyński, a diferencia del de Donoso Cortés, es poco conocido en España, a él se dedica una parte del artículo, la cual va seguida por un comentario acerca de la influencia que sobre el aristócrata ejercieron las ideas del pensador español, perteneciente a una generación más joven. A modo de ilustración sobre la relación que los unía, el texto se completa con tres cartas no publicadas de Raczyński a Donoso escritas entre 1851 y 1852.
Transparent Throughput Elasticity for Modern Cloud Storage
Authors: Nicolae Bogdan , Riteau Pierre , Zhen Zhuo , Keahey Kate
Published: May 2019

Storage elasticity on the cloud is a crucial feature in the age of data-intensive computing, especially when considering fluctuations of I/O throughput. In this chapter, the authors explore how to transparently boost the I/O bandwidth during peak utilization to deliver high performance without over-provisioning storage resources. The proposal relies on the idea of leveraging short-lived virtual disks of better performance characteristics (and more expensive) to act during peaks as a caching layer for the persistent virtual disks where the application data is stored during runtime. They show how this idea can be achieved efficiently at the block-device level, using a caching mechanism that leverages iterative behavior and learns from past experience. Second, they introduce a corresponding performance and cost prediction methodology. They demonstrate the benefits of our proposal both for micro-benchmarks and for two real-life applications using large-scale experiments. They conclude with a discussion on how these techniques can be generalized for increasingly complex landscape of modern cloud storage.
Quantifying Participation in Large-Scale Virtual Environments
Authors: Bishop Jonathan
Published: May 2019

The term large-scale virtual environment (LSVE) is not in the common usage. One might find discussion on massively multi-user online role-playing games (MMORPGs) and multi-user virtual environment (MUVEs), but these are sub-types of LSVEs and usually focus on the graphical element, not measuring the capacity of the individual users and the computation of their combined potential, nor the analysis of how they interact with one another to achieve mutual or opposite goals that affect the usage of data and their own nutritional resources. By investigating different user groups, internal and external representations and various thresholds, including the serendipity threshold, this chapter contributes to the understanding of how digital addiction manifests through a brain measurement called knol, which can be used as a floating-point unit.
On the Discriminants of the Powers of an Algebraic Integer
Authors: Louboutin Stéphane R.
Published: May 2019

For $\unicode[STIX]{x1D6FC}$ an algebraic integer of any degree $n\geqslant 2$, it is known that the discriminants of the orders $\mathbb{Z}[\unicode[STIX]{x1D6FC}^{k}]$ go to infinity as $k$ goes to infinity. We give a short proof of this result.
Viability of using wind turbines for electricity generation in electric vehicles
Authors: Rubio Francisco , Llopis-Albert Carlos
Published: May 2019

This paper presents a feasibility study of applying a fluid energy recovery system by means of wind turbines for charging batteries of electric vehicles. This is because the main disadvantage of electric vehicles with regard to conventional fuel automobiles is the scarce capacity of storing sufficient energy to run long distances. This can be carried out by recovering a percentage of the energy used to overcome the aerodynamic drag of the vehicle. This work analysis different case studies, with different driving modes, to quantify the theoretical energy recovered from the vehicle aerodynamics. Results have shown the theoretical possibility to implement this technology in actual electric vehicles.