bluuebunny/crossref_metadata_2025 huggingface dataset:
Emprendimiento rural como estrategia de desarrollo territorial: una revisión documental
Authors: Jurado Paz Irina Margarita
Published: May 2022

El emprendimiento es actualmente considerado como una herramienta para que los estados puedan impulsar el desarrollo tanto económico, social, productivo e incluso el cultural dentro de los territorios, sin embargo, pese a las bondades de esta tendencia existen aún desafíos considerables para que los aportes obtenidos sean realmente sostenibles e impactantes. En el presente artículo de revisión documental, derivado del proyecto de investigación doctoral “Fortalecimiento del emprendimiento rural como una estrategia de desarrollo territorial: empoderando a las comunidades para su propio bien-vivir”, tiene como objetivo principal estudiar sobre de qué manera se debería abordar el emprendimiento, en especial en entornos rurales para que se pueda considera una estrategia efectiva de desarrollo territorial; para ello se utilizó una metodología de revisión de literatura, de tipo descriptiva, fundamentada en la revisión de más de 50 publicaciones de alto impacto. La principal conclusión obtenida está asociada con que es importante incluir un enfoque de desarrollo humano integral y sostenible al proceso concepción del emprendimiento rural, en donde por supuesto, se involucre una estrategia más integradora, es decir, cuando el individuo desde sus conocimientos y saberes, se conecte a la posibilidad de crear una unidad productiva, siendo está la base para la promoción de un desarrollo territorial. Finalmente, se concluye estableciendo que los criterios tales como: desarrollo humano, nuevas ruralidades, fortalecimiento de las competencias emprendedoras, el concepto del buen-vivir, entre otros elementos propios de las comunidades campesinas, son puntos críticos a tener en cuenta para adaptar una tendencia de manera que se obtengan los máximos beneficios posibles para la población.
Computation optimization procedures for stochastic filtering and smoothing algorithms via Kalman filter
Authors: Полухин П.В.
Published: May 2022

Процедуры фильтрации и сглаживания, построенные на основе фильтра Калмана, используются в инженерных и экономических задачах для оценки вектора состояния линейных динамических систем в условиях зашумленных данных. Калмановская фильтрация представляет собой важный раздел в теории проектирования систем управления. Эффективность, точность и быстродействие работы стохастических алгоритмов фильтрации и сглаживания во многом определяются используемыми аналитическими и численными алгоритмами, осуществляющими вычислительные процедуры. В рамках данной статьи предложено несколько численных алгоритмов, направленных на оптимизацию калмановских процедур фильтрации и сглаживания.

Filtering and smoothing procedures based on the Kalman filter are significantly used in engineering and economic tasks to evaluate the state vector of linear dynamic systems in noisy data conditions. Kalman filtering is an important section in the theory of control system design. The efficiency, accuracy and speed of stochastic filtering and smoothing algorithms are largely determined by the analytical and numerical algorithms used to perform computational procedures. Within the framework of this article, several numerical algorithms are proposed aimed at optimizing Kalman filtering and smoothing procedures.
Development of an algorithm for ranking aircraft of a group air target according to the priority of their destruction by guided aircraft missil
Authors: Аюш К.Х. , Баланян С.Т. , Пригарин В.Н.
Published: May 2022

Разработанный алгоритм ранжирования воздушных целей – один из важнейших компонентов информационно-управляющей подсистемы управляемой авиационной ракеты класса «воздух – воздух», оснащенной активной радиолокационной головкой самонаведения. Осуществлено программно-математическое обеспечение алгоритмизации процесса ранжирования воздушных целей с использованием языка программирования MatLab&Simulink. Исследована возможность применения алгоритма для ранжирования групповой воздушной цели по дальности от группы управляемых авиационных ракет, скорости сближения и курсовому углу. Получена зависимость диаметра окружности области невозможных атак от скорости цели при различных значениях располагаемой перегрузки ракеты.

The developed air target ranking algorithm is one of the most important components of the information and control subsystem of an air-to-air guided missile equipped with an active radar homing head. The software and mathematical support for the algorithmization of the process of ranging air targets was implemented using the Matlab & Simulink programming language. The possibility of using an algorithm for ranging a group air target in terms of range from a group of guided aircraft missiles, approach speed and heading angle has been studied. The dependence of the diameter of the circle of the area of impossible attacks on the speed of the target is obtained for various values of the available rocket overload.
Smart home: comparison of wired and wireless technologie
Authors: Мельник О.Н.
Published: May 2022

Рассматриваются различия выбора способа связи между элементами системы «Умный дом», которая может быть проводной или беспроводной, а также способы доставки сигнала и основные протоколы беспроводной связи.

This article examines the choice of the method of communication between the elements of the “Smart House” system. It can be wired or wireless. Methods of signal delivery and wireless communication protocols are also analyzed.
FEATURES OF TRA NSLATION OF RUSSIAN BEHAVIORA L VERBS INTO VIETNAM
Authors: Нгуен Т.Т.Х.
Published: May 2022

Представлен анализ семантики русских и вьетнамских глаголов поведения. Структурно различные языки характеризуются единством в выделении семантических моделей поведения, таких как «хвастовство», «баловство», «обман», однако состав групп различается. В русском языке определенные типы поведения обозначаются при помощи глагольной лексики, во вьетнамском языке используются глагольные фразеологические обороты, сохраняющие метафорические образы. В русском языке объектом оценивания обычно становится субъект поведения, во вьетнамском языке оцениваются действия, в центре внимания сам поступок. Русские глаголы поведения переводятся на вьетнамский язык при помощи глагольно-именных оборотов, включающих элемент совершения каких-либо поступков и включающих вьетнамские слова, аналогичные русским «делать» и «совершать».

The article is devoted to the analysis of the semantics of Russian and Vietnamese behavioral verbs. Structurally diff erent languages are characterized by the unity in the selection of semantic models of behavior, such as “bragging”, “self-indulgence”, “deception”, but the composition of the groups is diff erent. In Russian language certain types of behavior are indicated with the help of verb lexicon. In Vietnamese language verbal phraseological turns preserve metaphorical images. In Russian the object of assessment is usually the subject of behavior. In Vietnamese actions are evaluated, the focus is on the act itself. Russian verbs of behavior are translated into Vietnamese thanks to verb-nominal phrases, which include the element of performing any actions and Vietnamese words similar to the Russian ones “to do” and “to do”.
Tutorías remotas para acelerar aprendizajes
Authors: Almeyda Gonzalo
Published: May 2022

Versión abreviada de la revisión de literatura sobre los efectos de las tutorías remotas como solución costo-efectiva para la aceleración de aprendizajes. Recupera experiencias de tutorías relevantes y propone un marco para su descripción y análisis.
How Does Market Competition Affect Firm Innovation Incentives in Emerging Countries? Evidence from Chile and Colombia
Authors: Benavente José Miguel , Zuñiga Pluvia
Published: May 2022

The effect of market competition on firm innovation remains controversial, especially in the context of developing countries. This paper presents new empirical evidence about the causal impact of competition on firm innovation for Chilean and Colombian manufacturing firms. Using instrumental-variable estimation, our results show that market competition increases firm propensity to invest in innovation, but this relationship manifests differently in the two countries. While this relationship is linear in Chilean firms, an inversed-U shaped relation prevails in Colombian firms. In both countries, however, innovation incentives are mostly concentrated in the medium range of the firm productivity distribution. These findings are robust to including past innovation engagement, import competition, and business dynamics. In addition, first- stage estimations show that competition law interventions improved market competition in sanctioned sectors while business entry reforms significantly leveraged competition across industries. These findings stress the importance of pro-competition regulations and competition policy, not only to benefit consumers welfare but also to support firm innovation.
Niepełnosprawny jako sportowiec
Authors: Niedbalski Jakub
Published: May 2022

The chapter refers to the notion of sport of persons with disabilities,putting the main stress on the role of their physical involvement in theprocess of activation, integration and social inclusion. I first of all try topresent specificity of sport of the disabled, and outline a genesis anddirections for development of sport of the disabled in Poland and aroundthe world. In further part of the chapter I will focus on demonstrationof institutional and structural circumstances related to sport practicingby the disabled. I will also refer to direct experiences of this categoryof persons, posing an illustration to the raised notions. The closing partof this paper is posed by conclusions related to diagnosis of a presentsituation of the disabled practicing sport, and recommendations forchanges in state policy towards them.
Niepełnosprawny (intelektualnie) jako osoba doświadczająca emocji
Authors: Nosal Przemysław , Zaręba Marta
Published: May 2022

The research shows that mental disabled people have special emotional needs. In effect, their emotional well-being is a challenge for the social policy. On the one hand, mental disabled people needs are slightly different than other disabled groups. On the other hand, due to communication barriers the problem is defining these needs precisely. This paper covers the topic of mental disabled people emotional needs. At the begging it describes the main problems with emotional well-being. Then, it presents the research about the disabled people emotions in four areas – safety, plans& dreams, emotional disorder and social bonds.
Relación entre los niveles de conocimiento y gestión de los costos de producción de los gerentes del sector gastronómico colombiano
Authors: Eslava-Zapata Rolando , Chacón-Guerrero Edixón , Parra-González Beatriz
Published: May 2022

Esta investigación estudia la relación entre los niveles de conocimiento y gestión de los costos de producción con las variables socio-demográficas de los gerentes. A partir de un estudio cuantitativo, se aplicó un instrumento en la escala de Likert a un grupo de 21 empresas de la industria gastronómica, en San José de Cúcuta, Colombia. Las hipótesis se contrastaron a través de un análisis de varianza y de un análisis de correlación de Pearson. Los resultados indican que existe una relación entre los Conocimientos de los Materiales Directos con los Años de Antigüedad de los gerentes. Igualmente, existe correlación entre los conocimientos y la gestión de los costos de producción por parte de los gerentes. Esto implica que, en la medida que los gerentes profundizan su experiencia sobre los costos de producción, podrán identificar con precisión los elementos del costo de los diferentes productos, asignando de forma eficiente los recursos económicos.
Hacia una formación investigativa en el programa administración de empresas de la universidad de la Amazonia (2021–2028), Caquetá – Colombia
Authors: Pardo-Rozo Yelly Yamparli , Andrade-Adaime Milton César , Correa-Cruz Lucelly
Published: May 2022

El objetivo de este artículo es diseñar una propuesta para fortalecer la formación investigativa en el programa Administración de Empresas de la Universidad de la Amazonia, Colombia. La investigación es de tipo descriptivo y propositivo.  Se determinó una muestra de 389 estudiantes por muestreo aleatorio simple. El estudio empleó análisis de correlación y la elaboración de una matriz DOFA (Debilidades, Oportunidades, Fortalezas, Amenazas). Los resultados indican que para el 70% de los estudiantes, la investigación es un proceso complejo y mentalmente desvinculado de su formación profesional. Se concluye con: la propuesta de actividades de sensibilización orientadas a los estudiantes, la identificación de unidades de curso que incluyan investigación aplicada, el fomento hacia la participación en grupos y semilleros de investigación, aumento de créditos académicos en la malla curricular como apoyo a la opción de grado y la restructuración de las líneas de investigación del programa.
Propuesta de un modelo de un proceso de gestión de la producción basado en gestión por procesos y buenas prácticas en las MyPes productoras de pecanas en Ica- Pachacutec con la finalidad de incrementar la productividad
Authors:   , Reyes Angulo Fabrizio , Muñante Zevallos Alejandra Paola
Published: May 2022

En este estudio se propone un modelo de un proceso de Gestión de Producción basado en buenas prácticas y desarrollado con herramientas de gestión por procesos con la finalidad de aumentar la productividad de los cultivos de Pecanas en la región de Ica en el distrito de Pachacútec como área de estudio. Este estudio abarca el diagnóstico y el desarrollo del modelo propuesto. La relación entre estas etapas es la principal función para la mejora de la productividad de los huertos de pecanas. Con el estudio realizado se demostró que para aumentar la productividad de pecanas de 0.9 (tn/ha) a 1.40 (tn/ha), así como para poder determinar las necesidades de materia prima, instrumentos y/o mano de obra, se necesita un proceso estandarizado de producción de pecanas. Las limitaciones en la región de estudio tienden a ser de accesibilidad a recursos, cantidad de personas que conforman las MyPes y al nivel de estudio de los mismos. La principal contribución de la investigación es el modelo propuesto de la nuez de pecana, la cual se basa en 3 partes: El planeamiento de la producción, la programación de la producción y el control de la producción. El planeamiento de la producción se encargará de realizar un planeamiento de recursos de las micro y pequeñas empresas de pecana en el Perú; la programación de la producción se basará en la realización de un cronograma de recursos de la producción y el control de la producción estará enfocado a un control basado en tarjetas para llevar un registro básico para estas empresas.
Transmisión de la política monetaria a la inversión de las empresas que cotizan en la Bolsa de Valores de Lima en función su apalancamiento: El Broad Credit Channel
Authors:   , Salazar Ramírez Oscar Rodolfo
Published: May 2022

El presente estudio pretende analizar si los cambios en la tasa de interés de referencia del Banco Central de Reserva del Perú pueden afectan de manera diferenciada a las decisiones de inversión de las empresas corporativas que cotizan en la Bolsa de Valores de Lima. Para tales efectos utilizaremos un modelo econométrico de datos de panel, a través del cual evaluaremos si el grado de endeudamiento de cada firma es un factor que condiciona el impacto de cambios en la tasa de interés de referencia sobre las inversiones que ésta realiza. En relación a este mecanismo, conocido como Broad Credit Channel, nuestros resultados brindan evidencia a favor de que este canal podría encontrarse operativo en el Perú, siendo un elemento que condiciona el impacto de un aumento de la tasa de interés sobre la inversión.
NIIF 9: Instrumentos Financieros y su impacto en la Gestión Financiera en las empresas agrarias de cultivos con fundos en la Región Ica que siembran y/o comercializan uvas y arándanos, año 2018
Authors:   , Diaz Arias Leslie , Hernández De la Cruz Jesús Guillermo
Published: May 2022

El presente trabajo de investigación presenta como objetivo general determinar el impacto financiero de la Norma Internacional de Información Financiera 9: Instrumentos financieros, relacionado con la Gestión Financiera en las empresas agrarias de cultivos con fundos en la Región Ica que siembran y/o comercializan uvas y arándanos, año 2018. A raíz de los nuevos cambios en la normativa contable con el objetivo de mostrar más fiables los instrumentos financieros. La investigación es de tipo aplicada. Nuestra población consta de 21 empresas agrícolas que poseen fundos en la región de Ica dedicadas al cultivo que siembran y/o comercializan uvas y arándanos. Con la finalidad de obtener un mejor entendimiento se realizaron entrevistas a dos expertos de una firma auditora, de los cuales una se caracteriza por ser experta en la revisión financiera de NIIF del sector, y uno es experto en NIIF. Así como encuestas a los encargados de la evaluación del impacto de las Normas Internacionales de Información Financiera y aplicación en la empresa. De esta forma, la investigación se diseñó en 5 capítulos. En el primer capítulo, se desarrolló el Marco Teórico, donde se describen las variables y dimensiones de la tesis con el contexto en el cual se ubica nuestra investigación. En el segundo capítulo, se describe el problema, los objetivos e hipótesis general y específicos. En el tercer capítulo, se describió la metodología de investigación donde se define el tipo de investigación, diseño, población, muestra para el análisis cuantitativo y cualitativo. En el cuarto capítulo, se desarrolló la aplicación de los instrumentos y el desarrollo de casos prácticos con el propósito de medir el impacto de la NIIF 9. Por último, en el quinto capítulo se analizó los resultados obtenidos en los instrumentos, conclusiones y recomendaciones finales donde se concluyó que la NIIF 9: Instrumentos Financieros no impacta en la Gestión Financiera en las empresas agrarias de cultivos con fundos en la Región Ica que siembran y/o comercializan uvas y arándanos, año 2018.
CINEMATIC REPRESENTATIONS OF INTERRACIAL MARRIAGE THROUGH THE LENS OF SOCIOLOGICAL THEORY
Authors:   PhD, Department of Sociology, Northern Arizona University, Flagstaff, USA, Beeman Mark
Published: May 2022

The Birth of a Nation (1915) was the first feature-length film to focus on the topic of interracial marriage. Its strong anti-miscegenation message and racial stereotypes set the stage for Hollywood depictions of race relations for decades. This anti-miscegenation theme was challenged in 1967 with the release of Guess Who’s Coming to Dinner. The purpose of this research is to analyze these two landmark films through the lens of sociological theory using the comparative case study method. Drawing primarily from the theoretical insights of paternalistic and competitive race relations theory allows us to interpret the films in their socio-historical contexts. The findings of this sociological reading alert us to the difficulties of the film industry in transcending its problematic lens on race relations.
THE PERCEPTION OF CROWDING AND PERSONAL SPACE DURING COVID-19: AN EXAMPLE OF GROCERY SHOPPING
Authors: ŞAHİN Betül
Published: May 2022

Covid-19 has reshaped the daily lives of people all around the world. Many regulations and changes have been made by the authorities in order to reduce the risk of transmission of the virus. Significantly, the regulations made by the government aim to reduce the number of people per square meter in closed areas and to increase the social distance between people. These regulations bring along new personal space and crowding perceptions. In this context, people's behaviors in many public spaces, from public transportation to grocery shopping, have gained a new texture. This change not only changed the perspective of the place but also caused a change in the perspective of people for one another. In this paper, environmental regulations aiming to adapt people's behaviors to social distance due to Covid-19 are examined in terms of personal space and crowding concepts. The purpose is to conduct an online interview with a retrospective approach and present the data as a narrative to determine the participants' perceptions of the random sampling method about personal space and crowding concepts before and after the pandemic. The research data were analyzed using the content analysis method in the QRS Nvivo qualitative data analysis program. In the results of the study, it was revealed that people's need for personal space in closed areas increased, and the crowding perception differed from the pre-pandemic due to psychological reasons through the example of grocery shopping.
Postoji li u Hrvatskoj duboka država?
Authors: Kuljanac Žaklina , Mikašinović-Komšo Matej
Published: May 2022

U radu se analiziraju oblici percepcije postojanja duboke države u Hrvatskoj ‎kod političara kao skupine. Prikazom relevantne literature te provedenih istraživanja ‎o rasprostranjenosti teorija zavjera u Hrvatskoj (posebice onih u vezi‎ s postojanjem duboke države), postavljaju se temelji na kojima se razrađuje ‎eksplorativna analiza polustrukturiranih intervjua s hrvatskim političarima.‎ Glavni nalazi analize intervjua ukazuju na prisutnost percepcije postojanja ‎duboke države među političarima svih političkih skupina te na raznovrsnost‎ načina kojima je ona percipirana i opisana. Iako se percepcije oblika duboke‎ države među ispitanicima razlikuju, svi koji smatraju da ona postoji dijele‎ pesimistično viđenje sadašnjosti i uvjerenje da u kontroverznim događajima‎ bitnu ulogu imaju skrivene interesne skupine.‎
PROFILE OF MIDDLE SCHOOL STUDENTS’ CONCEPTUAL UNDERSTANDING ABOUT THE DISEASE
Authors: Rahmadani Yesika , Ramli Murni , Saputra Alanindra
Published: May 2022

The concept of disease is taught at every level of education in Indonesia, but we found some discontinuity. Disjointed and not mutually sustainable concepts cause students’ understanding to be suboptimal. One example of a sustainable concept was the learning progression (LeaP) about the concept of disease proposed by the National Research Council (NRC). This study was aimed to test and find out: 1) The validity of the LeaP instrument about the concept of disease, 2) The grades 7th and 8th students’ understanding towards the concept of disease. 296 students of grades 7th and 8th from four public middle schools in Surakarta were selected as the samples. The school samples were selected purposively, while the students and classes were selected based on the recommendation by the teacher. The ex post facto quantitative non-experimental was used as the research method. The instrument was produced according to the LeaP scheme proposed by NRC (2007). The instrument was an Ordered Multiple Choice (OMC) test with multiple choice levels. Data were collected using tests, interviews, and documentation. The results showed: 1) The instrument items was valid with very high reliability, 2). The instrument difficulty level and distinguishing power need to be improved, 3) Grades 7th and 8th students who have level 3 understanding were ranged from 37% to 39.62%.
Performance Evaluation of Low-Cost Vibration Sensors in Industrial IoT Applications
Authors: Iqbal Ali ,   Centre for Precision Technologies, School of Computing and Engineering, University of Huddersfield Queensgate, Huddersfield, West Yorkshire HD1 3DH, United Kingdom, Mian Naeem S. , Longstaff Andrew , Fletcher Simon
Published: May 2022

The recent development of low-cost accelerometers, driven by the Industrial Internet of Things (IIoT) revolution, provides an opportunity for their application in precision manufacturing. Sensor data is often of the highest consideration in any precision machining process. While high-cost vibration sensors have traditionally been employed for vibration measurements in industrial manufacturing, the measurement uncertainty affecting the accuracy of low-cost vibration sensors has not been explored and requires performance evaluation. This research focuses on the characterization of measurements from low-cost tri-axial micro electro-mechanical systems (MEMS) accelerometers in terms of identifying the parameters that induce uncertainties in measured data. Static and dynamic calibration was conducted on a calibration test bench using a range of frequencies while establishing traceability according to the ISO 16063 series and the IEEE-STD-1293-2018 standards. Moreover, comparison tests were performed by installing the sensors on machine tools for reliability evaluation in terms of digital transmission of recorded data. Both tests further established the relationship between the baseline errors originating from the sensors and their influence on the data obtained during the dynamic performance profile of the machine tools. The outcomes of this research will foresee the viability offered by such low-cost sensors in metrological applications enabling Industry 4.0.
Study of the Load Forecasting of a Wet Mill Based on the CEEMDAN-Refined Composite Multiscale Dispersion Entropy and LSTM Nerve Net
Authors: Luo Xiaoyan , Huang Yaofeng , Zhang Fangwei , Wu Qingling ,   School of Mechanical and Electrical Engineering, Jiangxi University of Science and Technology 86 Hongqi Dadao, Zhanggong, Ganzhou, Jiangxi 341000, China,   Jiangxi Mining & Metallurgy Electromechanical Engineering Technology Research Center, Ganzhou, China
Published: May 2022

To address the problem of wet ball milling in a strong noise environment, it is difficult to accurately detect the internal load parameters of the cylinder during grinding. In this paper, a mill load parameter prediction method is proposed based on complementary ensemble empirical mode decomposition (CEEMDAN)-refined composite multiscale dispersion entropy (RCMDE) and-long and short-term memory (LSTM) neural networks. Using this method, the vibration signals of the mill barrel under strong noise were decomposed using the CEEMDAN algorithm, sensitive modal components with strong correlation with the original signal were selected for reconstruction using the correlation coefficient method, and features of the reconstructed signals under different load parameters were extracted through RCMDE. The load characteristic vector of an RCMDE mill was used as the input of LSTM neural networks, and the filling rate, material and ball ratio, and grinding concentration were used as the output to establish the internal load prediction model of wet mill. Experiment results show that the prediction method has a high accuracy, with average absolute percentage errors of the filling rate, feed-to-ball ratio, and grinding concentration of 6.08%, 3.50%, and 3.47%, and average absolute errors were of 0.0167, 0.0146, and 0.0146, respectively.
Calculation of levee-breach widening rates
Authors: Robbins Bryant , Corcoran Maureen
Published: May 2022

Inundation modeling is often conducted for levee systems to understand current flood risks. The extent of inundation caused by a breach in the levee is highly influenced by the widening rate of the levee breach. This study presents an approach for calculating levee-breach widening rates based on average flow velocity through the breach, embankment height, and erosion characteristics of the soil. Estimates of soil erodibility are derived through an analysis of the measurements of soil erodibility presented in the National Cooperative Highway Research Program (NCHRP) Report 915 database. Levee-breach widening rate curves are calculated based on these erosion properties to demonstrate the approach, and default curves are presented for typical levees built from coarse-grained soils and fine-grained soils. While the most accurate approach for a site is to calculate site-specific widening rate curves based on estimates of local soil erodibility, the default curves presented provide a suitable starting point for initial inundation modeling.
ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL- 10
Authors: Liu Yaping , Zhang Xinxin , Wang Jing , Yang Fuhuang , Luo Wei , Huang Jie , Chen Mengling , Wang Sha , Li Caolong , Zhang Wei , Chao Jie
Published: May 2022

Silicosis is a pulmonary fibrosis-associated disease caused by the inhalation of large amounts of free silicon dioxide (SiO2) that mainly manifests as early inflammation and late pulmonary fibrosis. As macrophage precursors, monocytes accumulate in the lung during early inflammation, but their role in the development of silicosis is unclear. Single cell sequencing, western blotting, quantitative real-time PCR, ELISA and cell functional experiments were used to explore the specific effects of monocytes on fibroblasts. The CRISPR/Cas9 system was used to specifically knock down ZC3H4 and was combined with pharmacological methods to explore the mechanism by which ZC3H4 affects chemokine and cytokine secretion. The results indicated that 1) SiO2 induced an infiltrating phenotype in monocytes; 2) infiltrating monocytes inhibited the activation, viability and migration of fibroblasts by regulating IL-10 but not IL-8; and 3) SiO2 downregulated IL-10 via ZC3H4-induced autophagy. This study revealed that ZC3H4 regulated the secretion function of monocytes, which, in turn, inhibited fibroblast function in early inflammation through autophagy signaling, thereby reducing pulmonary fibrosis. These findings provide a new idea for the clinical treatment of silicosis.
Exosomes from human induced pluripotent stem cells-derived keratinocytes accelerate burn wound healing through miR-762 mediated promotion of keratinocytes and endothelial cells migration
Authors: Bo Yunyao , Yang Lijun , Liu Baiting , Tian Guiping , Li Chenxi , Zhang Lin , Yan Yuan
Published: May 2022

Background
The use of keratinocytes derived from induced pluripotent stem cells (iPSCs-KCs) may represent a novel cell therapy strategy for burn treatment. There is growing evidence that extracellular vesicles, including exosomes, are primary mediators of the benefits of stem cell therapy. Herein, we thus explored the effects of exosomes produced by iPSCs-derived keratinocytes (iPSCs-KCs-Exos) in a model of deep second-degree burn wound healing and evaluated the mechanistic basis for the observed activity.
Methods
iPSCs-KCs-Exos were isolated from conditioned medium of iPSCs-KCs and verified by electron micrograph and size distribution. Next, iPSCs-KCs-Exos were injected subcutaneously around wound sites, and its efficacy was evaluated by measuring wound closure areas, histological examination and immunohistochemistry staining. The effects of iPSCs-KCs-Exos on proliferation and migration of keratinocytes and endothelial cells in vitro were assessed by EdU staining, wound healing assays and transwell assay. Then, high-throughput microRNA sequencing was used to explore the underlying mechanisms. We assessed the roles of miR-762 in iPSCs-KCs-Exos-induced regulation of keratinocytes and endothelial cells migration. Furthermore, the target gene which mediated the biological effects of miR-762 in keratinocytes and endothelial cells was also been detected.
Results
The analysis revealed that iPSCs-KCs-Exos application to the burn wound drove the acceleration of wound closure, with more robust angiogenesis and re-epithelialization being evident. Such iPSCs-KCs-Exos treatment effectively enhanced endothelial cell and keratinocyte migration in vitro. Moreover, the enrichment of miR-762 was detected in iPSCs-KCs-Exos and was found to target promyelocytic leukemia (PML) as a means of regulating cell migration through a mechanism tie to integrin beta1 (ITGB1).
Conclusion
These results thus provide a foundation for the further study of iPSCs-KCs-Exos as novel cell-free treatments for deep second-degree burns.
First demonstration of functional task performance using a sonomyographic prosthesis: a case study
Authors: Engdahl Susannah M. , Acuña Samuel A. , King Erica L. , Bashatah Ahmed , Sikdar Siddhartha
Published: May 2022

Ultrasound-based sensing of muscle deformation, known as sonomyography, has shown promise for accurately classifying the intended hand grasps of individuals with upper limb loss in offline settings. Building upon this previous work, we present the first demonstration of real-time prosthetic hand control using sonomyography to perform functional tasks. An individual with congenital bilateral limb absence was fitted with sockets containing a low-profile ultrasound transducer placed over forearm muscle tissue in the residual limbs. A classifier was trained using linear discriminant analysis to recognize ultrasound images of muscle contractions for three discrete hand configurations (rest, tripod grasp, index finger point) under a variety of arm positions designed to cover the reachable workspace. A prosthetic hand mounted to the socket was then controlled using this classifier. Using this real-time sonomyographic control, the participant was able to complete three functional tasks that required selecting different hand grasps in order to grasp and move one-inch wooden blocks over a broad range of arm positions. Additionally, these tests were successfully repeated without retraining the classifier across three hours of prosthesis use and following simulated donning and doffing of the socket. This study supports the feasibility of using sonomyography to control upper limb prostheses in real-world applications.
Identifying major yield limiting nutrients on sorghum (Girana one) for developing site-specific nutrient management practices in low lands of Eastern Amhara
Authors: Adissie Samuel , Teshome Habtemariam , Sisay Kassa , Hailu Tadesse
Published: May 2022

Background: Omission trial is a passionate way of identifying yield limiting nutrients. A field experiment was conducted for identification of yield limiting nutrients through crop response in Kobo with test crop sorghum (Girana one variety) for two years in three kebeles. The design for experiment was a randomized completely block (RCBD) using farmer field as replication. Biological yield data were collected and subjected to analysis of variance (ANOVA). Whenever there was significant difference between treatments, the means were separated using LSD test at P≤0.05. Results: The results showed that the omission of nutrients from inorganic fertilizer alone or in combination resulted in significance grain yield reduction. The highest grain yield was observed with the treatment receiving NPS+FYM whereas the lowest was omission of all nutrients (control). There was no significant difference in biomass yield between treatments for both years. Omission of all nutrients from inorganic fertilizer alone or in combination significantly reduced grain yield of sorghum. Application of FYM in combination with inorganic fertilizer (NPS) and NP contained treatments (NPS, NPSK and NPSKZN) can meet nutrient requirement for sorghum. Conclusions: This experiment shows a significant yield advantage of all applied nutrients compared to omitting nutrients. Application of farm yard manure was also significantly affected grain yield compared to the control. Based on this result, nitrogen and phosphorous fertilizers with farm yard manure rather than secondary and micro nutrients can be recommended in the study area for increasing production and productivity of the sorghum.
Scolicidal activity of essential oils and nanoemulsions of Satureja sahendica and Artemisia dracunculus on hydatid cysts protoscoleces
Authors: Tabari Mohaddeseh Abouhosseini , Youssefi Mohammad Reza , Hasanabadi Reza , Bazaz Mojtaba Mousavi , Mahmoudabadi Elnaz , Nekooei Negar , Shahavi Mohammad Hassan , Sammakkhah Shohreh Alian , Moghaddas Elham
Published: May 2022

Hydatidosis is a substantial zoonosis infection with a significant socio-economic burden. Surgery is the most effective treatment of hydatidosis. The utilization of scolicidal agents is a method to minimize the risk of distribution of infective protoscoleces during surgery. So far, most of the available scolicidals result in local or systemic side effects. Considering essential oils of Artemisia dracunculus and Satureja sahendica have shown several bioactivities, we decided to characterize A.dracunculus and S.sahendica nanoemulsions and evaluate the scolicidal activity of these two nanoemulsions and the EOs using albendazole as positive control. To reach this goal, 10 3 protoscoleces of E.granulosus in 1 ml medium M199 were exposed to four concentrations of 1, 2, 5, and 10 µg/ml of EOs and nanoemulsions at 30, 60, and 120-minute time points. For all tested plants, a significant effect of the treatments (F5,60=61.47, P<0.001), the time of exposure (F2,120=170.72, P<0.001) and their interaction (F10,120=4.32, P<0.001) were noted. The overall mortality rate in protoscoleces after exposutre to S. sahendica nanoemulsion was significantly higher than other treatments and it was 83.13% (P˂0.05). Among all the tested compounds of the present study, nanoemulsion of S.sahendica demonstrated the highest toxicity on protoscoleces and may serve as a candidate for research and development on novel scolicidas.
Perceived Benefit of Yoga Among Adults Who Have Practiced Yoga for a Long Time: a Qualitative Study
Authors: AKDENİZ Şengül , KAŞTAN Özlem
Published: May 2022

Background: Previous quantitative studies have shown many of the perceived benefits of yoga practice on the mind and body. Although there are many quantitative studies in the international literature on yoga, the number of qualitative studies showing the experience of yoga practice is insufficient. An accurate demonstration of yoga participents experiences, opinions, and judgments on this subject requires a qualitative, rather than a quantitative approach.Purpose: This study was to explore the benefit perceived by adults who have practiced yoga for a long time.Design and method: This qualitative study is based on a hermeneutic–phenomenological approach. The research sample consisted of 18 adults who volunteered to participate in the research and regularly joined yoga practice. The study were collected through individual and focus group interviews with the participants who practise yoga and analyzed by content analysis method.Results: We created five themes. Themes coded by researchers: meaning of the concept of yoga (theme 1), physical, mental and social state before starting yoga (theme 2), reasons for practising yoga (theme 3), the participants' experiences of related to their physical and mental health and social relationships (theme 4), difficulties of doing yoga (theme 5). In addition, individuals in the study their perceptions of the concept of "yoga", their mental “yoga is like …… in order to reveal the images and their causes. Because ……” metaphor were asked to complete their sentences. A justification for the metaphors produced by the research participants or the concept of “because” is included to provide a basis.Conclusions: Both individual and focus group in their interviews, almost all of the participants described that doing yoga has positive benefits on the mind and body. The positive experiences of the participants in the study; decrease in pain and flexibility, increase in sleep quality, development of positive personality traits, increase in self-esteem, and coping with anxiety and stress more effectively. Since the study was qualitative and long-term, it was evaluated the beliefs, attitudes and behaviors of individuals were evaluated in a more realistic, systematic and detailed manner.
Changes in physiological responses and immunity of blunt snout bream Megalobrama amblycephala suffering from transport stress
Authors: Wang Bingke , Wang Yanhui , Jia Tao , Feng Jianxin , Qu Changyi , Wu Xiaojun , Yang Xingli , Zhang Qin
Published: May 2022

This study aimed to investigate the effects of transport stress on the physiological responses and immunity of Megalobrama amblycephala. Fish (average weight: 109.67 ± 1.51 g) were taken at eight times intervals: before experiment (control), at 0h, 1h, 3h, 6h, 12h, 24h, 3d, 7d after 4 hours of long-distance transportation. The results showed that plasma cortisol, glucose, triiodothyronine (T3) complement component 3 (C3), complement component 4 (C4), total protein, immunoglobulin M (IgM), and nitrogen monoxide (NO) concentrations as well as alternative complement pathway (ACH50), lysozyme, acid phosphatase (ACP) and myeloperoxidase (MPO) activities increased first and then decreased with significant differences observed between treatments (P < 0.05). Liver heat shock protein 70 (HSP70) and heat shock protein 90 (HSP90) expressions both increased first and then decreased with significant differences observed between treatments (P < 0.05). However, after a long period of stabilization, all the indicators of t blunt snout bream had returned to their pre-transport levels. Overall, these findings suggested that 4 hours of long-distance transportation caused stress response of blunt snout bream, and transport stress had a significant effect on plasma indicators. But post-transport recovery could return the physiological response, immune indexes and the expression of heat shock protein to the normal level. This also provided data support for the long-distance transportation of blunt snout bream in the future.
The expression of Lin28 in gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin in vitro and in vivo
Authors: Li Xian , Kang Lihua , Peng Jiaqi , Han Wenyan , Su Xiulan
Published: May 2022

Background: Gastric cancer has become one of the major diseases threatening human health. This study aimed to investigate the effect and mechanism of an anticancer bioactive peptide (ACBP) combined with oxaliplatin (OXA) on MKN-45, SGC7901, and NCI-N87 differentiated human gastric cancer cells and GES-1 immortalized human gastric mucosal epithelial cells. And the therapeutic effect and action mechanism of short-term intermittent ACBP combined with OXA on nude mice with human gastric cancer were investigate.Methods: The half-maximal inhibitory concentrations of these agents in these cells were measured by an MTT assay, and cell morphological changes were observed by H&E staining. The expression of Lin28, miR-107, miR-609 and Let-7 in these four cell lines was determined by q-PCR after drug treatment. Lin28 protein expression in these four cell lines treated with these drugs was measured by western blotting. Furthermore, activity and quality of life were observed daily in all tumor-bearing nude mice, and the expression of Lin28 in tumor tissue was determined by immunohistochemistry and RT-PCR. Results: The results showed that ACBP inhibited the proliferation of MKN-45, SGC7901, and NCI-N87 gastric cancer cells in a dose-dependent manner and weakly suppressed the proliferation of GES-1 cells. Moreover, the inhibitory effect on proliferation was stronger in poorly differentiated gastric cancer cells. ACBP, OXA and the combination upregulated Lin28 gene expression in MKN-45 cells and downregulated it in SGC7901 and GES-1 cells. ACBP and the combination therapy downregulated Let-7 expression in MKN-45 cells and upregulated Let-7 expression in SGC7901 cells. The combination of ACBP with OXA has significant anticancer sensitization on oxaliplatin, and also significantly improves the quality of life of tumor-bearing nude mice and reduces the toxic side effects of chemotherapeutic drugs on nude mice. Conclusion: ACBP alone and in combination with oxaliplatin influenced the expression of tumor stem cell marker gene Lin28 and regulated the expression of microRNAs specifically regulated by Lin28. In addition, the anticancer effects and attenuated sensitization effects of ACBP may be related to the Lin28/miRNA-107 signaling pathway, acting by inhibiting the proliferation of cancerous stem cells.
Effect of age at first conception as selection criteria on growth and carcass traits in Nellore cattle
Authors: Brunes Ludmilla Costa , Baldi Fernando , Costa Marcos Fernando Oliveira e , Lobo Raysildo Barbosa , Lopes Fernando Brito , Magnabosco Claudio Ulhoa
Published: May 2022

Despite the economic importance of sexual precocity for beef cattle production systems, in heifers, this indicator is commonly assessed indirectly using the scrotal circumference or with age at first calving (AFCa), which can delay the identification of precocious females. The study aimed to investigate the genetic parameters for age at first conception (AFCo), AFCa, and their relationship with growth and carcass traits, to verify the possibility of using AFCo as selection criteria for the genetic improvement of sexual precocity. The AFCo was considered the age at which the female presented the first positive diagnosis for pregnancy. The estimation of (co)variance components and genetic parameters was performed using a linear animal model in two-trait analyzes. The heritability estimates were moderate. The highest genetic and phenotypic correlation were obtained between AFCo and AFCa (0.88 ± 0.13 and 0.96 ± 0.13, respectively). In general, genetic correlations estimates between sexual precocity-indicator and growth and carcass traits were moderate and negative. The results of this study encourage the use of AFCo in Nellore cattle since this trait displayed enough genetic variability in Nelore cattle, can be used as selection criteria to improve sexual precocity, and would not display an unfavorable effect on other profitability traits. Selection for animals with early ages at first conception and calving would increase the carcass yield, fat deposition and growth performance. When the selection objective is to increase the heifer sexual precocity, we could use the first trait as criterion, as the measurement of this trait occurs at a lower age at first calving.
Use of cellulose nanofibers to improve hydrophobic and oleophobic properties for polyvinyl alcohol coated paper
Authors: Huang Shancong , Wang Xiyun , Meng Yu , Hua Feiguo , Tong Shuhua , xia xinxing
Published: May 2022

The effect of the composite coating containing a mixture of polyvinyl alcohol (PVA) and cellulose nanofibers (CNFs) prepared from bamboo pulp on the hydrophobic, oleophobic and strength properties of paper was investigated. The results showed that the size of bamboo fibers (BFs) decreased significantly and the crystallinity increased significantly after biological enzyme treatment. The average length of CNFs obtained by high pressure homogenization was about 2.4 µm, the diameter was about 28.7 nm, and the crystallinity was 63.63%. When the coating weight of PVA/CNF was 2.0 g/m2 and the CNF dosage was increased from 0.0–3.0%, the paper grease resistance grade was increased from 7 to 9, the Cobb value was decreased from 22.68 g/m2 to 18.37 g/m2, the contact angle was increased from 67.82° to 93.56°, and the longitudinal and transverse tensile index were increased from 67.72 N∙m/g and 37.63 N∙m/g to 68.61 N∙m/g and 40.71 N∙m/g, respectively. When the CNF dosage was 3.0% and the coating weight of PVA/CNF was increased to 4.0 g/m2, the grease resistance grade of the paper reached 12, the Cobb value was 21.80 g/m2, and the longitudinal and transverse tensile indices were 72.11 N∙m/g and 42.58 N∙m/g, respectively. Overall, the addition of CNFs to the PVA coating significantly improves the oleophobic property of the coated paper, and the hydrophobicity and tensile strength are well maintained.