bluuebunny/crossref_metadata_2025 huggingface dataset:
Obstructive sleep apnea syndrome and cardiovascular risk factors in the antihypertensive therapy “escape” phenomenon
Authors: Mikhailova Oksana O. , Elfimova Eugenia M. , Litvin Aleksander Yu. , Chazova Irina E.
Published: February 2023

Aim. To assess the role of obstructive sleep apnea and other cardiovascular (CV) risk factors in the development of the antihypertensive therapy (AHT) efficacy escape phenomenon in patients with arterial hypertension (AH).
Materials and methods. The data of 75 patients with AH stage III, grades 13 were proceeded. All patients included in the study underwent night respiratory monitoring. After AHT prescription, blood pressure (BP) was monitored by three measurement methods (office, daily monitoring and self-control of blood pressure) initially, in 1, 3 and 6 months after the inclusion in order to confirm the initial therapy efficacy and to identify or exclude the escape phenomenon.
Results. In 36.0% of patients, the escape phenomenon was diagnosed in 1 or 3 months of observation. When comparing the group with the escape phenomenon, an initially higher level of systolic BP was revealed according to office measurements, 24-hour monitoring and self-control BP monitoring (134.04.7 mmHg vs 126.08.5 mmHg; 129.02.3 mmHg vs 121.07.7 mmHg; 131.08.2 mmHg vs 121.56.2 mmHg resp.; р0,05). There were no differences in sleep apnea and CV risk factors between the groups. However in patients with a minimal SpO285% during sleep, there were a higher levels of office systolic BP both before the AHT prescription, and during its use (157.610.4 mmHg vs 152.48.1 mmHg resp., р0,05; 132.06.8 vs 127.18.9 mmHg resp.; р0,05), and mean 24-hour systolic BP (125.75.9 vs 121.68.2 mmHg resp.; р0,05) compared with patients with a minimum SpO285%.
Conclusion. The higher BP level in patients with lover nocturnal hypoxemia does not allow us to exclude the delayed negative impact of obstructive sleep apnea, especially severe, on the BP profile in case of initially successful AH control.
Anemia and quality of life of chronic kidney disease patients on renal replacement therapy by programmed hemodialysis
Authors: Kotenko Oleg N. , Abolyan Liubov V. , Kuteinikov Vladislav Iu. , Vinogradov Vladimir E. , Fomin Victor V.
Published: February 2023

Aim. To study relationship between anemia and health-related quality of life (HRQOL) of chronic kidney disease stage 5 patients (CKD) undergoing renal replacement therapy by programmed hemodialysis.
Materials and Methods. The study was conducted on the basis of dialysis centers/departments in Moscow. The Russian-language version of the KDQOL-SFTM questionnaire, validated in Russia, was used to assess the HRQOL of patients on hemodialysis. A total of 723 patients were interviewed. Hemoglobin (Hb) levels were assessed in 442 patients based on outpatient records. To identify the relationship between Hb level and HRQOL scales, a correlation analysis was performed, as well as a HRQOL analysis in the three groups differing in hemoglobin levels (100; 100-120 and 120 g/l). Statistical data processing was carried by SPSS.22 and using parametric and nonparametric statistical methods.
Results. Correlation relationship was revealed between Hb and HRQOL of patients on hemodialysis on the scales "symptoms/problems", "pain", "vital activity, energy" and "total physical component of health". According to the scales "symptoms/problems" and "vital activity, energy", higher rates were noted among patients with Hb higher than the target level, which confirms the recommendations concerning the possibility of achieving higher Hb among individual patients who have not serious concomitant diseases and cardiovascular complications in order to improve their quality of life.
Conclusion. HRQOL assessment is important tool for planning and evaluating the effectiveness of anemia drug therapy among patients with CKD on hemodialysis.
Pharmacoeconomic evaluation of the tixagevimab and cilgavimab combination using for pre-exposure prophylaxis of COVID-19
Authors: Zhuravleva Marina V. , Chulanov Vladimir P. , Gagarina Julia V. , Shabalina Elena A.
Published: February 2023

Aim. To evaluate pharmacoeconomic feasibility using of the tixagevimab and cilgavimab combination for pre-exposure prophylaxis of COVID-19 in immunocompromised patients.
Materials and methods. Cost-effectiveness of tixagevimab and cilgavimab in persons 12 years old who weigh 40 kg and have either a history of allergy that prevents their vaccination against COVID-19 or moderate or immunocompromised was assessed based on PROVENT phase III study results. The quantity of life years or quality-adjusted life years gained was calculated. Direct medical cost associated with prophylaxis of COVID-19, treatment of infected patients and those experiencing long COVID post infection were assessed. Results were compared with wiliness-to-pay threshold, measured as tripled gross domestic product per capita and equal to 2.69 mln RUB in 2022.
Results. Pre-exposure prophylaxis of COVID-19 results in additional 0.0287 life years or 0.0247 quality-adjusted life years. The cost of additional life year gained is equal to 1.12 mln RUB, the cost of additional quality-adjusted life years is 1.30 mln RUB. Both costs of additional life year and cost of quality-adjusted life years appeared to be significantly less compared to wiliness-to-pay threshold.
Conclusion. Pre-exposure prophylaxis of COVID-19 with combination of tixagevimab and cilgavimab is economically feasible and may be recommended for wide use in Russian healthcare system.
ĐA DẠNG THÀNH PHẦN LOÀI CÁ RẠN SAN HÔ Ở VỊNH XUÂN ĐÀI TỈNH PHÚ YÊN
Authors: Hoàng Đình Trung , Nguyễn Hữu Nhật , Nguyễn Duy Thuận
Published: February 2023

Đã xác định được 65 loài cá rạn san hô thuộc 48 giống, 27 họ, 15 bộ của 2 lớp (cá Sụn – Chondrichthyes và cá xương – Osteichthyes) ở vịnh Xuân Đài, thị xã Sông Cầu, tỉnh Phú Yên. Trong số này, ghi nhận 30 loài có giá trị bảo tồn theo các thứ hạng khác nhau; 26 loài có giá trị giải trí, dùng trong nuôi làm cảnh, lặn ngắm cá và sử dụng trong câu cá thư giãn; 3 loài nuôi và 4 loài có khả năng gây nuôi; 15 loài có thể gây hại cho con người thông qua sát thương bằng gai vây và bằng vây đuôi.
ĐA DẠNG DI TRUYỀN QUẦN THỂ CÁ CHÌNH HOA (Anguilla marmorata) TẠI QUẢNG TRỊ
Authors: Nguyễn Anh Tuấn , Võ Đức Nghĩa , Trần Thị Thúy Hằng , Đào Tấn Học , Đặng Thanh Long
Published: February 2023

Nghiên cứu này được thực hiện nhằm đánh giá đa dạng di truyền của quần thể cá Chình hoa (Anguilla marmorata) tự nhiên tại tỉnh Quảng Trị dựa trên việc so sánh trình tự DNA của vùng gene điều khiển CR (control region) ty thể với các quần thể cá Chình hoa trên thế giới. Kết quả cho thấy khoảng cách di truyền giữa các cá thể trong quần thể dao động từ 0 đến 0,261, đạt trung bình 0,024. Trong 31 cá thể, 203 vị trí đa hình tách biệt (S) đã tạo ra 209 vị trí đột biến (Eta) với 31 kiểu haplotype khác nhau. Số lượng các nucleotide khác biệt trung bình là 29.299 (k); hệ số đa dạng nucleotide chiếm 26,09 × 10–3 (Pi); số lượng tối thiểu để xẩy ra quá trình tái tổ hợp (Rm) trong quần thể tương ứng với 51 sự kiện. Phần lớn cá thể thu được tại Quảng Trị có quan hệ di truyền gần gũi với quần thể cá Chình hoa Bắc Thái Bình Dương (27/31 cá thể) và 4 cá thể có mối quan hệ di truyền gần gũi với quần thể Nam Thái Bình Dương. Việc phát hiện các cá thể Chình hoa tại Quảng Trị có di truyền gần gũi với các cá thể thuộc Nam Thái Bình Dương được xem như một điểm đáng chú ý trong nghiên cứu này.
HIỆU ỨNG STARK QUANG HỌC CỦA EXCITON TRONG CHẤM LƯỢNG TỬ PHỎNG CẦU DẠNG DẸT InGaAs/InAlAs
Authors: Lê Thị Ngọc Bảo , Đinh Như Thảo
Published: February 2023

Trong bài báo này, chúng tôi nghiên cứu sự tồn tại của hiệu ứng Stark quang học của exciton trong chấm lượng tử phỏng cầu dạng dẹt bằng lý thuyết hàm sóng tái chuẩn hóa. Một sóng bơm mạnh đã được áp dụng để kết cặp các trạng thái lượng tử hóa của điện tử trong vùng dẫn trong mô hình hệ ba mức. Chúng tôi quan sát thấy hai vạch phổ hấp thụ liên vùng riêng biệt, thể hiện sự tách các mức năng lượng của điện tử do hiệu ứng Stark quang học. Đồng thời, các ảnh hưởng của năng lượng trường bơm, kích thước và dạng hình học của chấm lượng tử lên các đặc trưng của hiệu ứng cũng được khảo sát chi tiết.
THÀNH PHẦN HÓA HỌC VÀ HOẠT TÍNH CHỐNG OXY HÓA CỦA CÁC DỊCH CHIẾT TỪ HOA XUYẾN CHI (Bidens pilosa)
Authors: Lê Lâm Sơn , Lê Trung Hiếu , Nguyễn Quang Mẫn , Hồ Xuân Anh Vũ , Trần Thanh Minh , Nguyễn Việt Thắng , Nguyễn Đăng Giáng Châu , Lê Thuỳ Trang , Lê Thị Mỹ Linh , Trần Thị Văn Thi
Published: February 2023

Xuyến chi đã được sử dụng trong các bài thuốc cổ truyền Việt Nam. Khả năng chống oxy hóa của cao toàn phần và các cao phân đoạn từ hoa cây Xuyến chi được đánh giá thông qua ba mô hình: tổng khả năng chống oxy hoá, khả năng bắt gốc tự do DPPH và khả năng bắt gốc ABTS. Kết quả cho thấy cao ethyl acetate có khả năng chống oxy hóa tốt nhất với IC50 nhỏ nhất (IC50 = 31,54 μg·mL–1 và           IC50 = 35,33 μg·mL–1 tương ứng với khả năng bắt gốc DPPH và ABTS) và hàm lượng các chất chống oxy hóa cao nhất (85,05 ± 0,28 mg·g–1 acid gallic). Hàm lượng các hợp chất có hoạt tính sinh học (tổng các hợp chất phenol, tổng flavonoid, tổng triterpenoid và polysaccharide) trong dịch chiết hoa cây Xuyến chi được xác định bằng phương pháp trắc quang. Hàm lượng tổng các hợp chất phenol và flavonoid là 59,35 ± 0,83 mg GAE·g–1 và 42,35 ± 1,50 mg QE·g–1; hàm lượng polysacharide và triterpenoid là 4,44 ± 0,02% và 32,88 ± 0,66 mg acid oleanolic·g–1. Lần đầu tiên, tổng hàm lượng triterpenoid và polysacharide trong hoa Xuyến chi được công bố.
TỔNG HỢP VẬT LIỆU Ni/UiO-66 THEO PHƯƠNG PHÁP TRỰC TIẾP VÀ GIÁN TIẾP
Authors: Lê Thị Hòa , Lê Thị Thanh Nhi , Nguyễn Huyền Trang , Đoàn Thị Lệ Quyên , Hồ Văn Minh Hải , Đinh Thị Thu Thanh
Published: February 2023

UiO-66 là họ vật liệu khung hữu cơ kim loại tổng hợp bằng phương pháp nhiệt dung môi có diện tích bề mặt riêng lớn (1071 m2·g–1). Vật liệu UiO-66 này được biến tính bằng NiCl2 theo phương pháp trực tiếp (Nix(tt)/UiO-66) và gián tiếp (Niy(gt)/UiO-66). Kết quả đặc trưng hai vật liệu biến tính này bằng nhiễu xạ tia X, hiển vi điện tử quét và phổ hồng ngoại khác nhau không đáng kể. Tuy nhiên, phân tích nhiệt trọng lượng và đẳng nhiệt hấp phụ – khử hấp phụ N2 cho thấy có sự khác nhau giữa các phương pháp tổng hợp.
TỔNG HỢP VẬT LIỆU TiO2/rGO VÀ ỨNG DỤNG PHÂN TÍCH ĐỒNG THỜI CADIMI VÀ CHÌ BẰNG PHƯƠNG PHÁP VON – AMPE HOÀ TAN
Authors: Vũ Ngọc Hoàng , Vũ Thiên , Huỳnh Ngọc Thiết , Nguyễn Mậu Thành
Published: February 2023

Trong bài báo này, graphen oxit (GO) được tổng hợp từ bột graphit bằng phương pháp Hummer; GO được khử bằng axit ascorbic thành graphen  oxit dạng khử (rGO). Titan dioxit (TiO2) cấu trúc nano có tính ổn định vật lý và hóa học cao với nhiều ứng dụng, đặc biệt là trong lĩnh vực môi trường. Vật liệu TiO2/rGO được đặc trưng bằng nhiễu xạ tia X (XRD) và hiển vi điện tử quét (SEM) để chứng minh các đặc điểm hình thái của bề mặt chất hấp phụ. Quá trình hấp phụ – giải hấp phụ nitơ được sử dụng để xác định diện tích bề mặt riêng và độ xốp. Vật liệu vừa tổng hợp được ứng dụng để biến tính điện cực nền than thủy tinh nhằm xác định đồng thời hàm lượng cadimi và chì bằng phương pháp von-ampe hòa tan anot xung vi phân (DP-ASV). Độ nhạy của phương pháp đối với CdII và PbII là 0,329 ± 0,005 và 0,346 ± 0,004 μA/ppb. Giới hạn phát hiện đối với CdII và PbII là 3,17 và 2,42 ppb. Giữa Ip và nồng độ kim loại có tương quan tuyến tính tốt trong khoảng 6–80 ppb với R2 ≥ 0,998.
On the oscillation of nonlinear delay fractional partial differential equations with damping term
Authors: N Sasikala , V Sadhasivam
Published: February 2023

In this article we will consider the oscillation of nonlinear delay fractional partial differential equations with damping subject to Neumann boundary conditions.Sufficient conditions are obtained for the oscillation of solutions by using the method of generalized Riccati transformation.
A study on analytical solutions for stochastic differential equations via martingale processes
Authors: Syed Tahir Hussainy  , K Pathmanaban
Published: February 2023

In this paper, we propose some analytical solutions of stochastic differential equations related to Martingale processes. In the first resolution, the answers of some stochastic differential equations are connected to other stochastic equations just with diffusion part (or drift free). The second suitable method is to convert stochastic differential equations into ordinary ones that it is tried to omit diffusion part of stochastic equation by applying Martingale processes. Finally, solution focuses on change of variable method that can be utilized about stochastic differential equations which are as function of Martingale processes like Wiener process, exponential Martingale process and differentiable processes.
Stochastic fractional differential equations with generalized Caputo's derivative and impulsive effects
Authors: Chauhan Archana , Gautam Ganga Ram , Kumar Jitendra , Dabas Jaydev , S P S Chauhan
Published: February 2023

In this paper, impulsive stochastic fractional differential equations (ISFDEs) in Lp (p> 2) space are introduced. We present a general framework for finding solution for ISFDEs. Then, by using the Burkholder - Davis - Gundy inequality and Holder's inequality, we prove the existence and uniqueness of solution to ISFDE by fixed point theorem. We also investigate Lipschitz continuity of solutions with respect to initial values by using Gronwall inequality. Finally, we provide an application to illustrate the results we obtained.
On Paired Domination of Some Graphs
Authors: Isaac Rakhimol , Pandya Parashree
Published: February 2023

For a graph a subset D of the vertex set is called a dominating set if every vertex in is adjacent to some vertex in D. The domination number is the minimum cardinality of a dominating set of a graph G. The paired dominating set of a graph is a dominating set and the subgraph induced by it contains a perfect matching. The paired domination number is the minimum cardinality of a paired dominating set in G. In this paper, we discuss the paired domination number of the graphs obtained by the kth power of path and cycle and degree splitting graphs of some standard graphs.
On Connectivity of Zero-Divisor Graphs and Complement Graphs of some Semi-Local Rings
Authors: Subhash Mallinath Gaded  , Nithya Sai Narayana
Published: February 2023

Zero-divisor graphs have been a key area of focus for many researchers. For the semi local ring R of finite cartesian product of finite fields, we consider the zero divisor graph of R denoted by Γ(R) with vertex set as the non-zero zero-divisors of R where two vertices u and v are adjacent if and only if the product of u and v is the additive identity of the Ring R. The objective of this paper is to determine the number of cut vertices and cut edges, vertex connectivity and edge connectivity of the zero divisor graph Γ(R) and complement graph Γ(R).
RESULTS OF DENTAL IMPLANTS RESEARCH BY MEANS OF RESONANCE FREQUENCY ANALYSIS IN PATIENTS WITH OSTEOPLASTIC SURGERY PERFORMED FOR AUGMENTATION OF DEFICIENT ALVEOLAR RIDGE
Authors: S.V. Novikov
Published: February 2023

The use of dental implants being the intraosseous artificial fixtures is often required for orthopedic rehabilitation of completely edentulous patients; for their placement, adequate amount of bone tissue is needed, which in many cases is insufficient due to physiological bone loss, long-term wearing of full dentures, the duration of edentulism and complex clinical situations caused by maxillofacial injuries or general somatic diseases. Implant placement in the above situations requires timely preparation of deficient alveolar ridge by means of osteoplastic surgery. In its turn, the newly formed regenerated bone by its histological, physicomechanical and structural-functional properties can only approach the recipient bone tissue; therefore, the issue of implant osseointegration and its functional loading in regenerated bone remains debatable.
This research uses the method of frequency-resonance analysis showing implant stability coefficient numerically equal to the ISQ (Implant stability Quotient) values and reflecting the percentage of the osseointegration area of the intraosseous part of the implant. The results of research obtained by means of frequency-resonance analysis have proved that with the timely start of implant usage and adequate functional loading, ISQ values increase, that is, increases the osseointegration area along the interface of the intraosseous part of the implant placed in regenerated bone.
Comparative results of research reflecting ISQ values in 12 months after implant placement in bone augmented using various forms of autogenous bonegrafts, have been presented; therefore, a conclusion can be made that there is a direct relationship between osseointegration under conditions of functional chewing load and the shape and size of autogenous bonegrafts.
RETROSPECTIVE STUDY OF THE QUALITY OF LIFE OF PATIENTS WITH REDUCED ALVEOLAR PROCESSES IN WHICH REHABILITATION USED BONE PLASTY AND DENTAL IMPLANTATION
Authors: S.V. Novikov
Published: February 2023

In recent years, more and more attention has been paid to the problems of using dental implants in complex anatomical conditions due to bone deficiency. The probability of a favorable outcome after the treatment is quite high, which in turn is supported by the long-term results obtained after using various approaches in the rehabilitation of patients with a reduced volume of jaw bone tissue. Of course, the rehabilitation of such patients is difficult not only in terms of surgical preparation, but also in terms of orthopedic benefits, which impose restrictions on the capabilities of the patient's chewing and speech apparatus. In turn, the patient is faced with the task of maintaining as long as possible the result that the doctor originally sought, namely, using various methods of bone grafting, to create the necessary amount of bone tissue for the installation of implants, which are later used for orthopedic constructions, largely replenishing the functional characteristics. previously lost dentition. There are many studies that are devoted to modern methods of rehabilitation of patients with reduced alveolar processes of the jaws, however, only a small part affects the observation of delayed results of treatment of patients using bone grafting methods in combination with dental implantation. One of the advantages of this study is the ability to follow in dynamics what happens to these patients over a time period of up to 10 years, how strong the adaptive capabilities of the body are after major surgical interventions, what patient management tactics turned out to be the most effective. The assessment of the quality of life of such patients makes it possible to fully determine the feasibility of the operations and techniques to restore the function of the masticatory-speech apparatus.
The duration of the positive result obtained directly depends on the further interaction between the doctor and the patient. The key point is the dispensary observation of the patient, as a result of which the doctor gains clinical experience, and therefore the ability to predict further complications with one or another approach to the rehabilitation of patients in this category. On the other hand, for an objective assessment of the treatment performed, it is necessary to determine a common denominator that reflects the quality of life of our patients, therefore, the article presents the results of chewing assessment, as a fundamental criterion for the quality of life for most of these patients, using the SF-36 questionnaire, which is a kind of translator between subjective feelings of the patient and an objective assessment of the doctor.
ASSOCIATION OF NOS3 AND CYBA POLYMORPHISMS WITH FREQUENCY OF LIVER CIRRHOSIS IN PATIENTS WITH CHRONIC HEPATITIS B IN THE YAKUT POPULATION
Authors: Yu.A. Soloveva , N.V. Borisova , I.Sh. Malogulova
Published: February 2023

Chronic viral hepatitis B is a significant public health problem. Hepatitis virus carrier factors affect the course of chronic hepatitis B and odds of progression to liver cirrhosis. So, the research for the early development genetic predictors of complications of chronic hepatitis B is relevant. NOS3 and CYBA genes can act as predictor genes for early fibrotic processes in the liver. Researches confirm the role of oxidative stress and the mechanisms of cellular aging in the development of liver fibrosis. The purpose of this study is to identify the relationship between the carriage of polymorphisms of the NOS3 and CYBA genes and the development of liver fibrosis in patients with chronic viral hepatitis B in the Yakut population. Molecular genetic study of SNPs rs1799983 and rs1801131 of the NOS3 gene, rs4673 of the CYBA gene was carried out on 417 people. The collection of representative material was carried out on the basis of the Infectious Diseases Department of the Yakut Republican Clinical Hospital and the NEFU Clinic. As a result of a genetic study, it was found that in carriers of the mutant allele for the rs1799983 polymorphism of the NOS3 gene, the probability of developing liver cirrhosis is 1.81 times higher (0.176–0.098, CI 95%,), in carriers of the rs4673 mutant allele of the CYBA gene, the probability of developing liver cirrhosis is higher by 1.9 times (0.211–0.111, CI 95%), in carriers of the mutant allele for the rs2070744 polymorphism of the NOS3 gene, the probability of developing liver cirrhosis is 2.03 times higher (0.181–0.089, CI 95%). Thus, the obtained results indicate the need for additional studies of these genes, since they can be predictors of the development of liver cirrhosis in patients with chronic viral hepatitis B in the Yakut population.
CHARACTERISTICS OF DEMOGRAPHIC PROCESSES IN THE PRE-ARCTIC GROUPS OF THE EUROPEAN NORTH
Authors: A.L. Sannikov , R.A. Mustafin , V.A. Mustafina , R.V. Kubasov , A.G. Lukashov
Published: February 2023

Relevance: conducting a comparative analysis of demographic processes in two Arctic regions of the European North of Russia makes it possible to determine the main directions for improving the demographic policy of the territories. The aim of the study is to analyze mortality rates in the Komi Republic and the Arkhangelsk Region to assess demographic prospects in these regions. Materials and methods: the main demographic indicators that form the population decline in the Arkhangelsk region and the Komi Republic over the past 20 years were analyzed. A comparative study was conducted between them, as well as with the average statistical values in the Russian Federation. The main source of information was the website of the database of the Federal State Statistics Service. Results and discussion. Fluctuations in demographic indices in the Komi Republic and the Arkhangelsk Region as a whole have a similar trend and a common nature. Population losses in the Arctic territories of the country – the Arkhangelsk region and the Komi Republic as a whole are higher than the average for the Russian Federation. The greatest losses in these regions are formed due to high mortality from cardiovascular diseases in people of working age. Among the external causes of mortality, attention is drawn to the high suicide rate, which exceeds the national average in the Arkhangelsk region by 2.36 times, in the Komi Republic by 2.2 times. The deterioration in the level and structure of mortality in one region compared to another can be interpreted as a change in the quality of medical care during the period of negative changes associated with the COVID-19 pandemic. The analysis of the main demographic indicators in dynamics and in specific territorial entities makes it possible to identify possible predictors, causes of fluctuations in different time periods, the duration of responses to specific challenges and incentives.
COMMITMENT TO HEALTH-CREATING BEHAVIOR AMONG STUDENTS OF AN ENGINEERING AND TECHNICAL UNIVERSITY
Authors: A.G. Naimushina
Published: February 2023

The social problems of protecting the health of students are associated with the organization of an accessible educational environment in universities and the concept of disease prevention. Great importance is attached to the influence of traditional factors on health: smoking, alcohol, physical inactivity and overweight. It is quite difficult to assess the role played by secondary factors in maintaining health: stress resistance, sleep quality, full-time or part-time education. The purpose of the study was to conduct a comparative assessment of the prevalence of factors in the formation of commitment to health-building behavior among students of an engineering and technical university in indifferent groups. Materials and research methods: the process of self-assessment of health included a biographical research method, a block of sociological testing, a questionnaire, and an assessment of the quality of life. When describing the results of the study, the form of education and belonging to persons with disabilities are not mentioned. The students were divided into 3 groups depending on the state of health and the form of education. The hypothesis of the study was that they assumed a high correlation of behavioral risk factors in part-time students with a low level of stress resistance and a lower quality of life. We expected to receive information about the low quality of life in people with disabilities. During the study, the hypothesis was not confirmed. A high social status was determined for all respondents: the provision of separate housing, a living wage for one family member above the average, complete families. In both groups, full-time students have an equal attitude to personal health resources and a high level of stress. An analysis of behavioral factors of harm to health showed a significantly higher prevalence of smoking and a tolerant attitude to alcohol, high working capacity during the day and resistance to workload stress among students of distance learning. This fact caused difficulties in interpreting the relationship between traditional factors of harm to health and high indicators of the quality of life among working students. We noted general trends towards a decrease in smoking. All students showed a tendency to low reflection and understanding of lifestyle, which is confirmed by the biographical method of research and interviews.
NOVEL HYDROXYPYRIDINE DERIVATIVE PROTECTS NEURONS AGAINST ISCHEIC DAMAGE
Authors: R.M. Turmulaeva , K.I. Belanov , N.D. Bunyatyan , E.A. Eliseikina , O.V. Vasilkina , D.E. Timoshkin , P.S. Zamyshlyaev , E.V. Blinova
Published: February 2023

In this work, the cytoprotective effect of the original substance 3-hydroxypyridine ascorbate (3-EA) was studied. Cells for mixed cortical neuroglial culture were isolated from the brain (GM) of neonatal NMRI mice. The cell density in culture was adjusted to 15000 cells per 1 cm2. For experiments, 10-day-old cultures were used. To register the intracellular concentration of calcium ions ([Ca2+]i), cells were loaded with an intracellular fluorescent probe Fura-2AM dissolved in Hanks solution at a concentration of 4 μM, followed by 40-minute incubation at a temperature of 370C. Cells were washed three times before the experiment. Potassium chloride was applied to identify neurons, and short-term addition of ATP to the medium was used to detect glial cells (astrocytes). Cell cultures of the mouse cerebral cortex were preincubated for 24 hours with various concentrations (10, 50 and 100 μM) of 3-EA. The amplitude and shape of calcium responses were determined under conditions of oxygen-glucose deprivation (oxygen-glucose deprivation, OGD) and glutamatergic excitotoxicity (GluTox). Using fluorescence microscopy, cell viability tests, and PCR analysis, 3-EA has been shown to dose-dependently inhibit cortical cell death under glutamate excitotoxicity and ischemia/reoxygenation. Preincubation of cerebral cortex cells with 3-EA in the concentration range of 10–100 μM leads to a significant inhibition of the increase in Ca2+ ions in the cytosol ([Ca2+]i) of neurons and astrocytes in modeling glutamate excitotoxicity (GluTox) and oxygen-glucose deprivation (OGD). Decreasing [Ca2+]i and establishing a lower baseline [Ca2+]i inhibits necrotic cell death in an acute experiment.
GASTRIC LEIOMYOMA AND VITAMIN B12 DEFICIENCY ANEMIA COMBINED WITH OPISTORCHIASIS. A CLINICAL CASE
Authors: O.A. Baykova , N.N. Nikolaeva , E.G. Grishchenko , L.V. Nikolaeva
Published: February 2023

This case report demonstrates the interrelations between several clinical conditions: gastric leiomyoma, vitamin B12 deficiency anemia, and chronic opistorchiasis. A patient from diphyllobotriosis and opistorchiasis endemic territory presented with the symptoms of vitamin B12 deficiency. An endoscopic investigation found a 2 cm submucous node on the posterior wall of the stomach. Upon histological analysis, the node contained spindle-shaped cells with cigar-shaped nuclei without active mitoses and cell atypia. The immunohistochemical reaction to desmin and α-actin of smooth muscles was positive, while no CD117 and CD34 expression was found. These findings defined the node as a gastric leiomyoma. Multiple stool samples prepared with the Kato technique contained no Diphyllobothrium latum but Opistorchis felineus eggs were found. Kato method cannot rule out diphyllobotriosis completely. Simultaneously, opistorchiasis has no direct pathogenic interrelation with vitamin B12 deficiency anemia. Leiomyomas express the VPAC2 receptors. This makes the gastric glands more sensitive to the vasoactive intestinal polypeptide (VIP) that inhibits gastric secretion. Another possible mechanism that contributes to the vitamin B12 deficiency is autoimmune, where leiomyomas induce the antibodies against the Castle factor. However, the role of a combination of leiomyoma and opistorchiasis is still under discussion. Thus, this case should encourage the future research on the contribution of opistorchiasis to the onset of gastric leiomyoma.
TREATMENT OF PSYCHOGENIC PAIN SYNDROME IN CHILDREN AND ADOLESCENTS DURING ANTITUMOR THERAPY
Authors: O.A. Suetina , N.E. Kravchenko
Published: February 2023

Relevance: pain syndrome is a common phenomenon in oncopediatrics, and pain control and proper treatment tactics remain relevant to date. Objective: to generalize the experience of approaches to the therapy of psychogenic pain syndrome in children and adolescents with oncological and oncohematological diseases at the stage of antitumor treatment. Methods: traditional clinical and psychopathological, clinical and catamnestic methods and scale methods were used for psychiatry. Research material: children and adolescents who were treated at the Research Institute of the Russian Scientific Research Center and the Oncological and Oncohematological departments of the Morozovskaya DGKB DZM in 2020-2022. Results: 32 patients were selected from all those examined with suspected psychogenic pain, whose pain syndrome corresponded to the concept of "psychogenic algic syndrome". It was noted that female patients prevailed among patients with psychogenic pain.The patients were characterized by an exaggerated description and perception of pain sensations, the intensity of pain was associated with an emotional background, current events. Typical for patients were personality accentuations, as well as such psychopathological manifestations as anxiety, reduced mood background, fears, hypochondriac fixation. The proposed treatment tactics included medical (medicinal) and non-medical methods (psychotherapy, work with parents and caring adults). Conclusions:integrative models of therapy (a combination of medicinal and non-medicinal methods) for psychogenic pain syndrome show their high effectiveness.
CHANGES IN LIPID METABOLISM DURING THE INITIAL PERIODS MYOCARDIAL INFARCTION COMPLICATED BY ACUTE KIDNEY INJURY IN YOUNG AND MIDDLE-AGED MEN
Authors: A.V. Gordienko , A.V. Sotnikov , B.B. Tassybayev , D.V. Nosovich , B.A. Chumak
Published: February 2023

Relevance. Changes in lipid metabolism during myocardial infarction (MI) complicated by acute kidney injury (AKI) are potentially important for evaluating the effects of therapy and expanding the possibilities of prevention.
Aim. To evaluate the changes in lipid metabolism during acute and subacute MI periods and their role in the complication’s development in men under 60 years old (y.o.) with AKI to im-prove prevention and outcomes.
Material and methods. The results of inpatient examination and treatment of men aged 20-60 y.o. with MI were studied. Patients were divided into two age-comparable groups: the study group, with AKI - 22 patients and the control group, without it - 141 patients. The parameters of lipid metabolism and their dynamics were compared in the first hours (1) and at the end of the third week of MI (2) in selected groups, their influence was assessed (risk analysis by Pearson's Chi-square test) on the risk of AKI development and complications MI in the study group.
Results. In the study group, the following were observed: higher levels of low-density lipo-protein2 (LDL2) (5.53±2.50 mmol/l) compared to the control group (3.33±2.45 mmol/l; p=0.02); an increase in the levels of very low-density lipoproteins, a coefficient and an atherogenic index, a decrease in triglycerides (TG) at the end of the third week of the disease. The risk of AKI development was associated with the concentration of TG1≥1.88 mmol/l (p=0.007). Complicated course of MI in the study group is characterized by levels of LDL1≥4.0 (p=0.02), high-density lipoprotein1 (HDL1)˂1.1 (mmol/l; p=0.02), and their ratio (LDL1/HDL1) ≥4.5 (p =0.02).
Conclusions. In AKI, persistent atherogenic changes in lipids are noted both in the acute and at the end of the subacute period of MI. The risk of developing AKI increases at levels of TG1≥1.88 mmol/l, and the complicated course of MI in the study group is associated with lev-els of LDL1≥4.0, HDL1˂1.1 (mmol/l) and LDL1/HDL1≥4.5. It is expedient to use them in predictive modeling.
AN OUTBREAK OF UNKNOWN VIRAL HEPATITIS IN CHILDREN IN 2022
Authors: R.V. Kubasov , M.I. Mytsuk , Y.A. Lenina , E.D. Kubasova , V.V. Lupachev
Published: February 2023

Viral hepatitis is an extremely serious medical and social problem for humanity. The consequences of chronic hepatitis cause major social, economic and other losses. The most common causes of hepatitis are toxic damage, infectious disease, radiation exposure, ischemic and autoimmune process. As a rule, the causative agents of viral hepatitis are types A, B and C. However, other forms of hepatitis have also been verified, which are still poorly understood, for example, caused by other viruses – TTV, SEN, rubella, cytomegalovirus, HIV. In 2022, acute hepatitis of unknown origin was recorded in the UK among primary school children. Within a few weeks, the disease began to spread rapidly in a number of European countries. By the end of the second month since the outbreak began, the number of new cases exceeded 120 children. A characteristic feature of the manifestation of this disease was a severe, transient course, poorly treatable. In several cases, liver damage was irreversible (organ transplantation was required) up to a fatal outcome. But the most important problem of this new disease was the extremely difficult verification of its causative agent. For a long time, scientists could not establish the serological affiliation of the infectious agent, so for several months the disease was referred to as hepatitis of unknown etiology. Among the many hypotheses about the origin of the hepatitis virus under study, adenovirus is currently considered the most likely. However, it is still a mystery how the intestinal serotype of adenovirus (41F) became tropic to liver cells and, accordingly, why it causes acute diseases that occur in a very severe form.
A.N. MOTNENKO – DOCTOR, SURGEON, ARCTIC EXPLORER, RECTOR, TALENTED ADMINISTRATOR (ON THE 120TH ANNIVERSARY)
Authors: A.Yu. Ionov , I.V. Kryuchkova , T.A. Demisheva
Published: February 2023

Anton Naumovich Motnenko (1902-1953) was a prominent Fig.in the Kuban and domestic healthcare. The purpose of this study is to evaluate the contribution of A.N. Motnenko to the development of the Arctic, practical healthcare, the formation and development of higher medical education in Kuban and the country, and his administrative and organizational abilities. The article presents new and little-known facts of A.N. Motnenko's biography and the stages of his personality formation. A native of a peasant family, graduated from a medical institute in Rostov-on-Don, graduated as a surgeon. At the age of 31, he was appointed head of the polar winter quarters and at the same time a doctor on Franz Josef Land (1933-1934), where he successfully solved administrative issues, coped with the epidemic with the flu epidemic. He was personally acquainted with the legendary Arctic explorer I.D. Papanin. At the age of 33, he became the director of the Kuban Medical Institute. The Red Army (1943-1944), ensured the work of the university during the Great Patriotic War and the evacuation. Further administrative career: Director of the Medical Institute in Rostov-on-Don (1944), Deputy People's Commissar of Health of the RSFSR (1944-1949), Rector of the Odessa Medical Institute (1949-1951). All periods of A.N. Motnenko's biography reflected his outstanding personal and professional qualities. Along with personal charm, kindness to employees, he possessed Exceptional abilities as an organizer and manager, which were in demand during a difficult period in the history of our country. In the available Russian and regional sources, the issues of A.N. Motnenko's activities are presented incompletely, contain a number of inaccuracies, there is no single publication reflecting all aspects and stages of his activity, which is the novelty of this work.
MARKETING ANALYSIS OF THE PHARMACEUTICAL MARKET OF DRUGS FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS
Authors: R.O. Nikitin , I.A. Filina , G.V. Varenykh , Yu.E. Sangalova , O.S. Lositskaya
Published: February 2023

Content analysis of statistical data for the Russian Federation and the Belgorod region showed a trend of increasing prevalence of type 2 diabetes mellitus. Currently, according to the State Register of Patients with Diabetes Mellitus and the Federal State Statistics Service, as of January 1, 2022, more than 4.5 million patients were registered in Russia, which is slightly more than 3.1% of the country's population. In the Belgorod region on 01.01.2021, the number of patients with type 2 diabetes was 57,634 people or 3.74% of the population of the region. The increase in the dynamics of the prevalence of diabetes mellitus, its complications, disability and mortality determine the expediency of studying the range of lipid-lowering drugs to improve medical and pharmaceutical care for diabetic patients. The purpose of the study was a marketing analysis of the pharmaceutical market of medicines for the treatment of type 2 diabetes mellitus. Information and reference literature on the range of medicines registered and approved for use in the Russian Federation, Internet resources, supplier offers, scientific works of Russian and foreign scientists were used as objects of research. The study and analysis of the assortment were carried out using a wide range of methods and approaches to research, including generalization and data mining, general scientific analysis tools, statistical methods. In the course of the study of the range of lipid-lowering drugs in the domestic and local markets, the multidimensional characteristics of these segments were obtained. Based on the maximum indicators of the assortment, macro- and mesocontures of target segments of the markets of medicines for the treatment of type II diabetes mellitus have been developed: domestic and Belgorod markets of drugs for the treatment of type II diabetes mellitus
The types are represented by: mostly subgroup A10BA - "Biguanides", according to the active substance "Metformin". In terms of composition, drugs with one active ingredient in solid dosage form in the form of tablets are leading. The coefficient of assortment renewal in the Russian pharmaceutical market was 0.75, in Belgorod – 0.51. In general, the study showed that the pharmaceutical market of the Russian Federation has a significant resource for pharmacotherapy of type 2 diabetes mellitus, which provides an opportunity for interaction between pharmaceutical specialists and healthcare professionals to provide pharmaceutical and medical care.
ASSOCIATION OF ANEMIA WITH EXTRASYSTOLIA IN PATIENTS WITH SENIOR ASTHENIA
Authors: N.V. Aksyutina , E.L. Davydov , T.Yu. Bolshakova , D.A. Nadezhdina , I.S. Voronin , Yu.S. Suleymanov , A.V. Matryonina , V.V. Kusaev
Published: February 2023

According global population aging there is an increase in the absolute and relative numbers of people in older age groups. Therefore, senile asthenia (SA) is very relevant. An association between SA and cardiovascular disease has been proven. In addition, there is an increase of aging anemia. At the same time, mortality in patients with anemia, including anemia, which is caused by cardiovascular diseases, increases. Purpose of the study: To study the association of anemia with cardiovascular pathology in patients who have SA syndrome. 168 over 65-year-old patients were examined. The main group contains 60 patients with SA syndrome (37 men, 23 women); control group includes 108 people (68 men, 40 women) without SA syndrome. The median age of patients in the main group did not statistically significantly differ from the median age of people in the control group (82 years ±7.4 [75.00; 84.00] years versus 78 years ±7.1 [65.00; 82.00] years, p=0.605). All patients had a comprehensive geriatric assessment (CGE). Statistically, anemia in patients with SA is diagnosed more frequently in comparison with patients without SA (51.67% vs. 33.33%, p<0.001). Statistically, significant negative correlations were determined among the hemoglobin level and senile asthenia (r=-0.222; p<0.001), hematocrit and senile asthenia (r=-0.224; p<0.001). There are statistically significant direct correlations between anemia in patients with SA with frequent supraventricular extrasystole (r=0.152; p=0.049) and frequent ventricular extrasystole (r=0.154, p=0.047). Conclusion: The association of SA with anemia was confirmed, whereas anemia in patients, who have SA syndrome, affects the occurrence of frequent supraventricular and frequent ventricular extrasystoles.
PECULIARITIES OF THE COURSE OF PREGNANCY WITH MANIFESTATION OF COVID-19 INFECTION IN THE THIRD TRIMESTER
Authors: I.V. Sakhautdinova , R.I. Gromenko
Published: February 2023

Women during gestation are considered to be at high risk of viral respiratory infections with conversion to pneumonia due to physiological changes in the immune and cardiopulmonary systems. This research publication examined the peculiarities of the course of pregnancy, obstetric and perinatal outcomes during pregnancy against the background of a new coronavirus infection COVID-19 and assessed the changes in laboratory indices. Objective. to evaluate the features of the course of pregnancy with COVID-19 manifestation in the third trimester. Materials and Methods. 139 pregnant women at 28 weeks' gestation or more, including 112 pregnant women admitted to the obstetric department of an infectious diseases hospital with a confirmed diagnosis of COVID-19 and with mild to moderate degrees of infection, and 27 pregnant women in the antenatal clinic, who were conventionally healthy. The first group of pregnant women was divided into two subgroups, depending on the prescription of low molecular weight heparins for the prevention of venous thromboembolic complications (55 and 57 subjects, respectively). We evaluated the data of gynecological anamnesis, extragenital diseases, peculiarities of pregnancy course, clinical characteristics of COVID-19, comparison of laboratory tests. The features of the course of infection and pregnancy with altered blood parameters: lymphopenia, elevated levels of C-reactive protein, D-dimer were considered in the acute period of infection. The correlation between the gestational age at infection and the term of delivery as a result of the treatment was analyzed. The presence of iron deficiency anemia was considered as an additional risk factor for new coronavirus infection in pregnant women. Changes in the levels of fibrinogen, C-reactive protein, D-dimer may be the main markers in predicting the course of COVID-19 infection. Prescription of low-molecular-weight heparins at the initial stage of therapy may serve as a factor that allows prolongation of pregnancy to a pre-term term.
OBSTETRIC TACTICS IN PREMATURE PREGNANCY COMPLICATED BY PREMATURE RUPTURE OF THE MEMBRANES, THE CONDITION OF THE FETUS AND NEWBORN
Authors: L.I. Dyatlova , I.E. Rogozhina , V.N. Nechaev , O.N. Sergeeva , T.N. Glukhova
Published: February 2023

The present study is due to the high urgency of the problem of managing preterm labor initiated by premature rupture of the membranes. The purpose of this study was to analyze obstetric and neonatal outcomes during the prolongation of preterm pregnancy complicated by premature rupture of the membranes, and to assess the health status of newborns. Clinical observations were carried out on the basis of the State Health Institution "Clinical Perinatal Center of the Saratov Region".In 148 patients with a singleton pregnancy (the main observation group) at a period of 28-34 weeks, prenatal rupture of water occurred, while the pregnancy was prolonged to achieve greater morphological and functional maturity of the fetus. In 181 patients with a singleton pregnancy at the same gestational age, preterm labor occurred within the next 6-12 hours after prenatal rupture of water; these patients were included in the comparison group. Pregnancy in patients of the main group was prolonged by an average of 12.2±1.9 days (from 2 to 29 days). The paper presents the structure of indications for terminating the prolongation of preterm pregnancy with prenatal rupture of water, an analysis of the characteristics of the course of the birth act and the structure of indications for delivery by caesarean section in patients with premature pregnancy after a period of prolongation of gestation. A comparative analysis of the condition of 148 children born to patients of the main group and 181 newborns born to women of the comparison group showed the advantages of expectant management of patients with premature rupture of the membranes during preterm gestation. A decrease in the frequency of development and severity of respiratory disorders, the frequency of occurrence and degree of intraventricular hemorrhages in premature babies with the prolongation of a premature pregnancy complicated by prenatal rupture of water has been proven.