bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of factors influencing the level of environmental risks of ferrous metallurgy companies
Authors: Kazakova N. A. , Kogdenko V. G.
Published: March 2021

Environmental safety is one of the Russian metallurgical companies’ leadership key requirements in the world market, in which the environmental friendliness of goods and services production is one of the important competitive advantages. The study aimed to develop methodological approaches to assessing the environmental risks of the largest Russian ferrous metallurgy companies based on public data. The approach proposed by the authors includes the substantiation of an algorithm for assessing environmental risks from identifying factors that have a significant impact on the level of environmental risks of ferrous metallurgy companies, the choice of indicators - indicators and a scale for their assessment to the formation of a consolidated rating of companies and its interpretation. The methodological basis of the study was the regulatory documents on environmental safety; sustainable development standards in the field of ecology; rating agencies’ data and information; metallurgical companies’ information from the Internet resources, their financial, environmental and annual reports; analytical reviews, works of foreign and Russian scientists on environmental issues; security, monitoring data conducted by the Russian Union of Industrialists and Entrepreneurs. In assessing environmental risks, data from 9 ferrous metallurgy companies included in the Forbs rating of the largest private companies in Russia were used: PJSC “NLMK”, PJSC “Severstal”, PJSC “MMK”, “EVRAZ” Group, PJSC “Mechel”, “Metalloinvest” Group, “OMK” Group, PJSC “TMK”, PJSC “ChTPZ”. This article includes the results of the first stage of the study, which consists in identifying the characteristics of the compared companies that affect the level of environmental risks, which include: the organizational structure of the business (scale, geography of activities, structure of holdings), financial condition (availability of financial resources, their directions investments, primarily investments in the reconstruction of production facilities), as well as the availability of information to assess the company’s impact on the environment. The article was prepared in the framework of the grant in the priority areas of research FSBEI HE Plekhanov Russian University of Economics on the topic “Monitoring of sectoral financial security risks in the digital environment using the Harvard paradigm of industry analysis”.
Test trials of a process to produce briquettes from coal mining waste
Authors: Ketegenov T. A. , Kamunur K. , Yushina T. I. , Kalugin S. N.
Published: March 2021

At the present time, coal production wastes up to 2 % of fine fraction, which has adverse impact on the environment. On the other hand, coal fines can be a feedstock to obtain different products of chemical processing—benzines, oils, briquettes, etc. For this reason, it is necessary to develop dedicated technologies to utilize fine waste in manufacture of products having high added value. The experimental results demonstrate usability of wheat bran as a binder in coal waste briquetting. It is found how the binder and the briquetting conditions influence the physical and mechanical properties and combustion characteristics of coal briquettes. The optimized coal briquetting conditions are: carbonization of feedstock, use of binder in quantity of 25–30 mass%, briquetting pressure of 4 MPa. Thus, the authors have analyzed the influence of the briquetting conditions on the properties of coal briquettes, and have tested the earlier developed approaches to transformation of Oi-Karagai coal fines into a target product of high added value. The authors appreciate participation of A. Karagulanov, fellow of the Al-Farabi Kazakh National University in this study. The work was performed with the grant support of the Ministry of Education and Science RK-A RO 08957618.
Sportif Rekreatif Aktiviteye Katılan Bireylerin Serbest Zaman Doyum Düzeyleri ve Optimal Performans Duygu Durumlarının Arasındaki İlişkinin İncelenmesi
Authors: HADİ Gaye , ERDEM Büşra , DUMAN Erhan
Published: March 2021

Bu çalışmanın amacı; sportif rekreatif aktivitelere katılan bireylerin serbest zaman doyum düzeyleriyle optimal performans duygu durumları arasındaki ilişkiyi incelemektir. Ayrıca katılımcıların serbest zaman doyum düzeyleri ve optimal performans duygu durumlarını cinsiyet ve katılma sebepleri açısından incelemektir. Çalışmanın örneklemi seçkisiz olmayan örnekleme yöntemlerinden uygun örnekleme yöntemi kullanılarak belirlenmiş ve 261 kadın (Ortyaş=22.49 ±5.64) ve 293 erkek (Ortyaş=22.63 ±5.37) bireyden oluşmaktadır. Araştırmada veri toplamak amacıyla kişisel veri formu, Serbest Zaman Doyum Ölçeğinin kısa versiyonu ve Sürekli Optimal Performans Duygu Durum Ölçeği kullanılmıştır. Elde edilen veriler, tanımlayıcı istatistik, korelasyon analizi, bağımsız gruplar t testi ve ANOVA kullanılarak analiz edilmiştir. Analiz sonuçlarına göre katılımcıların optimal performans duygu durumları ve serbest zaman doyumları arasında pozitif yönde anlamlı ve yüksek derecede bir ilişki olduğu görülmüştür (r=.600, p<.01). Katılımcıların serbest zaman doyum puanlarının cinsiyet değişkenine göre anlamlı olarak farklılaşmadığı görülürken (t=-1.776, p=.078), kadın ve erkek katılımcıların optimal performans duygu durumu puanları arasında anlamlı farklılık olduğu görülmüştür (t=-2.554, p=.011). Ayrıca, katılımcıların serbest zaman doyumlarının (F(2-551)=1.173, p>.05) ve optimal performans duygu durumu (F(2-551)=1.816, p>.05) puanlarının sportif rekreatif aktivitelere katılım sebeplerine göre farklılaşmadığı görülmüştür. Serbest zaman doyumu ile optimal performans duygu durumu arasında ilişkinin ortaya konması, pozitif duygu durumlarının deneyimlenmesinin bireylerin serbest zamanlarından elde ettikleri doyumla yakından ilişkili olduğunu desteklemektedir.
Optimal Performans Duygu Durumu, Zihinsel Dayanıklılık, Takım Sargınlığı ve Antrenör Sporcu İlişkisinin Yordayıcısı Olarak Mizah Tarzı: Adolesan Sporcular Üzerine Çalışma
Authors: MERDAN Halis Egemen , AŞÇI F. Hülya
Published: March 2021

Bu çalışmanın amacı, adolesan sporcuların optimal performans duygu durumu, zihinsel dayanıklılık, antrenör sporcu ilişki kalitesi ve takım sargınlığı kavramlarının mizah tarzları ile ilişkisinin incelenmesidir. Çalışmaya 2019-2020 sezonunda İstanbul’da futbol, basketbol, voleybol, hentbol ve su topu branşlarında mücadele eden 139 kız (X𝑦𝑎ş=15,44±1,00), ve 213 (X𝑦𝑎ş=15,73±1,41) erkek olmak üzere toplam 352 (X𝑦𝑎ş=15,61±1,27) adolesan sporcu gönüllü olarak katılmıştır. Çalışma kapsamında sporculara “Kişisel Bilgi Formu”, “Mizah Tarzları Ölçeği”, “Sürekli Optimal Performans Duygu Durum Ölçeği Kısa Formu”, “Sporda Zihinsel Dayanıklılık Ölçeği”, “Antrenör Sporcu İlişkisi Ölçeği”, “Genç Sporcu Takım Sargınlığı Ölçeği” uygulanmıştır. Verilerin analizinde çoklu hiyerarşik regresyon analizi kullanılmıştır. Yapılan regresyon analizi sonucunda katılımcı mizah tarzının, optimal performans duygu durum, (β= 0,12, p<0,05), zihinsel dayanıklılık (β= 0,18, p<0,01), antrenör-sporcu ilişki kalitesi ölçeğinin yakınlık (β= 0,12, p<0,05), bağlılık (β= 0,13, p<0,05), tamamlayıcılık alt boyutlarının (β= 0.12, p<0,05) ve takım sargınlığının sosyal sargınlık alt boyutunun (β= 0,14, p<0,05) pozitif yordayıcısı olduğu bulunmuştur. Ayrıca kendini geliştirici mizah tarzı optimal performans duygu durumun (β= 0,23, p<0,01) pozitif yordayıcısıdır. Öte yandan, saldırgan mizah tarzının optimal performans duygu durumun (β=-0.12, p<0,05), zihinsel dayanıklılığın (β= -0,25, p<0,01), antrenör-sporcu ilişkisi kalitesi ölçeğinin yakınlık (β= -0,21, p<0,05), tamamlayıcılık alt boyutlarının (β= -0,21, p<0,01) ve takım sargınlığının görev sargınlığı alt boyutunun (β= -0,14, p<0,05) negatif yordayıcısı olduğu bulunmuştur. Elde edilen bulgular, katılımcı ve saldırgan mizah tarzının, optimal performans duygu durum, zihinsel dayanıklılık, antrenör sporcu ilişki kalitesi ve takım sargınlığı düzeylerinin önemli yordayıcıları olduğunu göstermektedir.
60 Yaş Üstü Bireylerin Yaşam Doyumu, Sağlık Algısı ve Boş Zaman Etkinliği Tercihlerinin İncelenmesi
Authors: AYNA Çağla , GÜMÜŞ Hüseyin
Published: March 2021

İçinde bulunduğumuz yüzyılda dünyayı kasıp kavuran Covid-19 pandemisi nedeniyle sosyal ilişkilerin tekrar gözden geçirildiği, belli yaş grupları için sokağa çıkma yasaklarının uygulandığı ve yüz yüze iletişimin, kolektif davranışların sorgulandığı bu süreçten en çok etkilenen ve ne yapması ya da ne yapmaması en çok tartışılan grup şüphesiz 65 yaş üstü bireyler olmuştur. Pandemi sürecinden önce verileri toplanan bu araştırmanın amacı, 60 yaş üstü bireylerin katıldıkları boş zaman etkinlik türleriyle yaşam doyumu ve sağlık algısı arasındaki ilişkiyi incelemektir. Araştırmanın evrenini Mersin'de yaşayan 60 yaş ve üzeri bireyler oluşturmaktadır. Araştırmaya bu evrenden amaçsal örneklem metoduyla seçilen toplam 391 kişi katılmıştır. Araştırmada veri toplama aracı olarak; “Yaşam Doyumu Ölçeği” ve “Sağlık Algısı Ölçeği”nin yanı sıra katılımcıların boş zaman etkinlik türlerine katılım sıklığını belirlemek için 6 farklı etkinlik türünü içeren “Boş Zaman Etkinlik Türü Anketi” kullanılmıştır. Yaşam doyumu, sağlık algısı ve boş zaman etkinlik türü ilgisi arasında istatistiksel olarak bir ilişki olup olmadığını belirlemek amacı ile de Spearman sıra farkları korelasyon analiz tekniği kullanılmıştır. Yapılan analizler sonucunda; 60 yaş üstü bireylerin tercih ettikleri boş zaman etkinlik türü “ev merkezli sosyal etkinlikler” ile “kültürel ve eğlence içerikli etkinlikler” iken en az tercih edilen etkinlik “fiziksel etkinlikler” ile ‘’gönüllülük ve sosyal sorumluluk etkinlikleridir’’. 60 yaş üstü erkeklerde yaşam doyumu ile boş zaman etkinlik türü arasındaki en yüksek ilişki gönüllülük ve sosyal sorumluluk etkinlikleri (r=0.206) arasında iken 60 yaş üstü kadınlarda kültürel ve eğlence içerikli etkinlikler (r=0.286) arasındadır. Sağlık algısı ile arasında en yüksek ilişki olan boş zaman etkinliği ise kadınlarda (r=0.413) ve erkeklerde (r=0.418) “hobiler ve iç mekân etkinlikleri” olarak tespit edilmiştir.
REVITALIZATION OF THE HISTORICAL QUARTER. EXPERIENCE IN APPLYING THE CONTEXTUAL APPROACH
Authors: ORLOVA Natalia A. , ORLOV Dmitry N. , GARSHINA Anastasia A.
Published: March 2021

For the Samara architecture of our time, the urgency and priority of the problem of preserving and developing the historical center is obvious. This study is at the forefront of the current controversy on this issue and gives its own version of the solution to the problems. The practical signifi cance of the research is a new articulated and visualized experience of reconstructive actions in the historical environment. The method of urban planning analysis of the site in order to identify the reserves of the territory is proposed. Methods of working with the architectural form necessary for preserving the morphotype of the old city in the conditions of modern development are shown. Conclusions and recommendations based on specifi c urban planning material are formulated.
“Los dardos” de Lázaro Carreter al lenguaje de género
Authors: Guerrero Salazar Susana
Published: March 2021

A partir del concepto de ideología lingüística y de las propuestas metodológicas para el Análisis Crítico del Discurso, en este artículo se lleva a cabo un análisis pragmático cualitativo de un corpus de columnas sobre la lengua (CSL) de Fernando Lázaro Carreter, que están incluidas en dos libros: El dardo en la palabra (1997) y El nuevo dardo en la palabra (2003). Se trata de las columnas publicadas en prensa que abordan la feminización del lenguaje en cualquiera de sus manifestaciones (CSLM). El objetivo de este trabajo es determinar qué temas se tratan en estas columnas, qué relación guardan con sus contextos históricos y cómo muestran la identidad ideológica de Lázaro Carreter. Hemos concluido que en el Nuevo dardo se introducen dos temas que no aparecían en el primer dardo: por un lado, los procedimientos igualitarios (principalmente las formas desdobladas del discurso político) y, por otro, el uso de la palabra género (procedente del anglicismo gender). Para mostrar su desacuerdo con ambos temas, Lázaro Carreter emplea los mismos argumentos que la Academia Española ha seguido defendiendo posteriormente tanto en sus obras de referencia como a través de los medios de comunicación y redes sociales, convirtiéndose así en el primer y más destacado académico en difundir la argumentación de la RAE en torno al lenguaje inclusivo en el periodismo de opinión.
Dos antologías de las Noches áticas publicadas en Argentina: José María de Cossío (1952) y Santiago Sentís Melendo (1959)
Authors: García Jurado Francisco
Published: March 2021

Se analizan y comparan dos antologías de las Noches áticas de Aulo Gelio publicadas en Argentina en 1952 y 1959: la de José María de Cossío y la de Santiago Sentís Melendo, respectivamente. Mientras la primera incide en el interés anecdótico y curioso de la obra de Gelio, la segunda desarrolla una lectura jurídica. En cualquier caso, ambas antologías muestran un renovado interés por las Noches áticas, obra que desde el siglo XVII era considerada como una mera compilación.
Evidencialidad como posible herramienta de manipulación? La evidencialidad quechua en algunas traducciones de textos religiosos
Authors: Bernárdez Sanchís Enrique
Published: March 2021

En estas páginas analizamos la evidencialidad quechua en algunos textos religiosos cristianos contemporáneos, para comprobar si su funcionamiento es el habitual o muestra discrepancias achacables a alguna forma de manipulación. Estas traducciones al quechua muestran un funcionamiento de la evidencialidad distinto al habitual. ¿Se debe ello a un intento de manipulación religiosa-ideológica? Para ubicar estos textos en el contexto gobal de la lengua quechua, la primera parte es un repaso del sistema evidencial quechua, así como un breve análisis de su funcionamiento en textos escritos antiguos (siglos XVI y XVII), junto con textos narrativos del siglo XX. La segunda parte incluye el análisis de los textos religiosos contemporáneos.
Analysis of Factors Affecting Human Development Index in Special Regional of Yogyakarta
Authors: Fadillah Nurul , Setiartiti Lilies
Published: March 2021

This study aims to analyze the factors affecting the Human Development Index in the Special Regional of Yogyakarta. This study uses secondary data from the Central Bureau of Statistics (BPS) and the Regional Asset Financial Management Agency (BPKAD) in the Special Regional of Yogyakarta, namely Yogyakarta City, Sleman Regency, Bantul Regency, Kulon Progo Regency, and Gunung Kidul Regency in 2013- 2018. Meanwhile, the analysis tools used in the study used the Panel Data Method with the Fixed Effect Model approach. This study indicates that the Gross Regional Domestic Product (PDRB) and government spending in the health sector positively and significantly affect the Human Development Index. Government spending in the education sector has a negative and insignificant effect on the Human Development Index (HDI).
Pulgar en gatillo, pulgar en resorte, o tenosinovitis estenosante del pulgar pediátrico
Authors: Migoya Nuño Alfonso , Fraind Maya Gabriel , Loyo Soriano Luis Eduardo
Published: March 2021

El pulgar en gatillo es una patología de etiología idiopática en la que el tendón  flexor largo del pulgar se encuentra engrosado proximal a la polea A1 generando una discrepancia de tamaño que impide el deslizamiento del tendón a través dicha polea, Se presenta de manera global en 3 de cada 1000 RNV siendo mas común en población hispana,  su diagnóstico es clínico por lo que no se requieren estudios de extensión, la resolución espontánea de esta patología se presenta en el 30% de los casos aproximadamente,  porcentaje que puede aumentar si se realiza terapia física; sin embargo los pacientes que no presentan mejoría deben ser referidos al ortopedista pediátrico para recibir tratamiento quirúrigico.
IoT Telemonitoring System for COVID-19 Quarantine
Authors: Saraubon Kobkiat , Limthanmaphon Benchaphon
Published: March 2021

The global COVID-19 outbreak has been spreading to 235 countries around the world. The quarantine can prevent the spread of disease. In this research, we developed and proposed an IoT telemonitoring system for quarantine employing IoT and mobile technologies. The system allows medical staff to monitor body temperature and track the location of every single quarantine person remotely by using a mobile device. When the body temperature is greater than the threshold (38.0 °C), the system sends an alert to the medical staff via the mobile application. They can take the quarantined person to test for COVID-19. The average error of the system was less than 1%. The evaluation results reveal that the users were satisfied with the system.
Influence of thin-layer soil analogues on the production process of lettuce plants in intensive artificial-light culture
Authors: Udalova O. R. , Anikina L. M. , Khomyakov Yu. V. , Vertebniy V. E. , Dubovitskaya V. I. , Panova G. G.
Published: March 2021

Relevance.The solution to the problem of providing the population of our country with high - quality plant production all year round is possible when creating high-tech automated phytotechnological complexes based on innovative, resource-saving technologies for growing plants in an artificial climate, including the development of a new generation of root inhabited thin-layer analogues of soils.

Materials and methods. The research was carried out under controlled conditions of intensive artificial-light culture, when growing lettuce plants of the Typhoon variety on thin - layer analogs of soil of various composition and a low-volume soil analogue based on high-moor peat with a low degree of decomposition "Agrofit", selected as a reference for comparison, in plant growing light equipment developed at Agrophysical Institute.

Results. Evaluation of the influence of thin-film analogues of the soil based on the suspensions Cambrian clay, and /or sapropel in different ratios on the production process of lettuces showed when compared with control (hydrophilic fabric): a positive tendency to increase of height, number of leaves per plant; a significant increase in wet mass by 25-35%, dry mass in 54-80%, percent dry matter in 16-36%; increase of leaf area and photosynthetic capacity at 20-36%, net productivity of photosynthesis by 16-45%; a significant or in a form of tendency to increase in the content of potassium by 14-17%, calcium by 27-35%, zinc by 29-53% and disaccharides by 28-68%. In comparison with the low-volume analogue of the soil based on high-moor peat of a low degree of decomposition "Agrophyte" (standard), it was found an increase in the form of a pronounced positive trend in growth indicators - the height and number of leaves. wet, dry mass of plants, percentage of dry matter; net productivity of photosynthesis, a reliable or in form of trend to increase in leaf area, photosynthetic potential by 20-30%; an increase in the content of mineral elements in lettuce leaves. Possible reasons for the lower productivity of lettuce plants in the control were determined, and it associated with an increase in water intake in leaf tissues against the background of the absence of additional mineral and / or organic nutrition. The content of heavy metals and nitrates did not exceed the maximum permissible concentration (MPC) in all variants. All thin-layer analogs of the soil with the application of suspensions of various compositions can be recommended for growing lettuce in any cultivation facilities in conditions of intensive artificial-light culture.
Regulatory support for the organic market (in the world, EAEU countries, Russia)
Authors: Pivovarov V. F. , Razin A. F. , Ivanova M. I. , Meshcheryakova R. A. , Razin O. A. , Surikhina T. N. , Lebedeva N. N.
Published: March 2021

The article presents international and national documents providing regulatory support for the organic market. Organic agriculture, as a special direction of agricultural production, requires separate legislative regulation due to the specifics of relations arising in the process of production, sale and marketing of products, the availability of internationally recognized standards and certification procedures. Most of the countries of the world community have their own characteristics of the development of the sector of organic agricultural products, its production, marketing and regulation of these processes, regulatory support of the market for organic products. Organic farming in Russia today can rely on a system of legal regulation of organic production, including international and interstate acts on organic agriculture (JFOAM, FiBL, Codex Alimentarius Commission, regulations of the EAEU, EAEU and CIS), Federal law (93) and national state RF standards, regional laws and programs for the development of organic agriculture, certification organizations. Prior to the approval and implementation of the Federal Law on organic products at the regional level, several regions of the Russian Federation developed their own regulatory documents that allowed their producers to produce organic products. The legal impact on the formation of the organic market occurs not only through laws of direct action, but also through general economic laws, regulations, state programs, local regulations (for example, private standards of organizations), etc. The current procedure for passing certification in foreign countries and for Russian producers of organic products. The factors and conditions that allow to stimulate producers to increase the production of organic products, to pass the required and necessary certification of farms and products, making local products more competitive in comparison with other similar products are identified.
Biofortification of chervil with selenium
Authors: Kharchenko V. A. , Golubkina N. A. , Moldovan A. I. , Caruso G.
Published: March 2021

Relevance.Production of functional food with high levels of antioxidant status and selenium is essential for human protection against viral and cardiovascular diseases as well as cancer.

Methods.Evaluation of the efficiency in foliar sodium selenate biofortification (25. 50 and 75 mg Se/L) was achieved on three chervil genotypes.

Results.Intervarietal differences in biofortification level was demonstrated: from 15.5 to 31.1 for 25 mg Se/L dose; from 36.9 to 64.6 for 50 mg Se/L dose; and from 72.9 to 130 for 75 mg Se/L dose. At the chosen doses, selenium supply did not affect significantly the yield, antioxidant properties and photosynthetic content of chervil. Total antioxidant activity was in the range from 30 to 42 mg GAE/g d.w., phenolics content from 9 to 13 mg GAE/g d.w, flavonoids from 5 to 12 mg-eq quercetin/g d.w., ascorbic acid from 33 to 66 mg/100 g fresh w. High levels of carotene were a typical feature of Se fortified and non-fortified chervil. A direct correlation was recorded between phenolics content and total antioxidant activity (r=+0.954, P<0.01), and between water soluble compounds and nitrates accumulation (r=+0.920, P<0.01). Biofortification with selenium did not affect significantly the mineral content of plants. Consumption of 100 g of fresh chervil leaves, fortified with selenium, provides from 50 to 75% of the adequate selenium consumption level and from 16 to 20% of potassium. Taking into account that both selenium and potassium normalize heart activity, the new functional food product may be recommended for prophylactics and treatment of cardiovascular diseases and for the human selenium status optimization.
MITOCONDRIA: La energía de la vida
Authors:   Universidad San Ignacio de Loyola, De La Fuente Diez Canseco Luciana , Alvarado-Ortiz Ureta Carlos ,   Universidad San Ignacio de Loyola, Blanco Teresa ,   Universidad San Ignacio de Loyola
Published: March 2021

Libro dirigido fundamentalmente a estudiantes de ciencias de la salud y ciencias de los alimentos que ofrece una amplia descripción de la mitocondria, el único organelo del cuerpo humano dedicado a brindarle la energía que requiere para la actividad celular. Incluye un capítulo sobre las enfermedades mitocondriales, aquellas que le impiden a estos ‘soldados’ del organismo cumplir sus funciones, con la consiguiente aparición de diversos males.
Treatment Adherence to Drug Therapyin Patients with Stable Coronary Artery Disease During the COVID-19 Pandemic
Authors: Martsevich S. Y. , Lukina Y. V. , Zharkova E. D. , Kutishenko N. P.
Published: March 2021

The new coronavirus infection (COVID-19) pandemic and the subsequent quarantine measures, particularly home isolation of the population, could have seriously affected the quality of pharmacotherapy and adherence to it by patients with chronic non-communicable diseases.

Aim. To assess the dynamics of adherence to pharmacotherapy by patients with stable coronary artery disease (SCAD) in self-isolation during the COVID-19 pandemic.

Material and methods. To accomplish the aim of the study, we selected 39 patients with SCAD who previously completed the ALIGN study, the purpose of which was to align patients’ medical therapies according to current clinical guidelines. From May 05, 2020, to May 14, 2020, a telephone survey was conducted of 39 patients with SCAD (37, 94.8%) males, mean age 67.6±8.5 years). After one year of participation in the ALIGN study, 87.1% of the patients were adherent to their prescribed pharmacotherapy. Adherence (overall and to specific medications) was assessed by means of the original adherence scale, which made it possible to identify violations in taking medications (non-adherence to the intake regime or discontinued intake of medications), and the main reasons for adherence violation were established. Adherence registered during the telephone survey at the time of the COVID-19 pandemic was compared to that obtained during the last time the patient participated in the ALIGN study.

Results. During the period of home isolation, a substantial decline in the adherence of patients to pharmacotherapy was revealed. The percentage of adherent patients decreased from 87% to 54% due to an increase in the number of patients who stopped taking several or all of the recommended drugs during home isolation (p=0.024). The overall rate of adherence during the COVID-19 pandemic appeared to be even worse than before the start of the ALIGN study. A comparative analysis of subgroups with and without a decline in adherence revealed a trend suggesting that higher patient education (p=0.067) or previous percutaneous coronary intervention (p=0.063) can be considered a protective factor associated with fewer violations in adherence during the COVID-19 pandemic. Analysis of adherence to specific drugs showed that during self-isolation there was a decrease in adherence to antiplatelet drugs (p=0.047) and to statins (p=0.055). Adherence to beta-blockers, renin-angiotensin-aldosterone system inhibitors and dihydropyridine calcium antagonists remained unchanged.

Conclusion. In patients with SCAD during the period of home isolation in the COVID-19 pandemic and associated difficulties in contacting the attending physician, there was a decline in adherence and an increase in the number of patients who stopped taking several or all prescribed drugs.
Registration of Medicines in the Soviet Control and Licensing System on the Example of the Cardiological Drug Trinitrolong
Authors: Petrenko A. N. , Vasiliev P. A. , Martsevich S. Yu. , Kutishenko N. P. , Zvonareva O. I.
Published: March 2021

The article presents the history of the study and registration in the USSR of the buccal form of nitroglycerin (trinitrolong) in the 1970s and 1980s, based on a number of author's publications, documentary evidence and oral stories of participants in clinical trials. The specifics of the passage of the main stages of registration of a new pharmacological agent in the Soviet control and authorization system from the author's idea to the introduction of the drug into clinical practice are described. Some reasons for the lag of the USSR from the countries of the capitalist West in the development and introduction of new cardiac drugs are analyzed.
A Clinical Case: the Risk Factors of Acute Kidney Injury in a Cardiological Patient
Authors: Son E. A. , Kondratyuk M. R. , Fominykh E. V. , Fomin V. V.
Published: March 2021

Recent epidemiological studies have demonstrated that the development of a potentially reversible moderate acute kidney injury is associated with worsening clinical outcomes and an increased risk of death. This is especially true for patients with plural comorbidities who require procedures with IV radiopaque agents. This paper presents a clinical case of an elderly patient who requires coronary angiography, and who has common clinical conditions such as hypertension, multifocal atherosclerosis with the development of renal artery disease and the presence of a history of acute cerebrovascular accident and myocardial infarction, and chronic heart failure as well. Particular attention is given to assessing the risk of developing contrast-induced acute kidney injury in patients with cardiovascular disease, as well as discussing current views on the possibility of prescribing drugs that affect the reninangiotensin system in cardiac patients with concomitant renal artery disease.
Bone and Body Composition Analyses by Dxa in Adults With Gh Deficiency: Effects of Long-term Replacement Therapy
Authors: Rossini Alessandro , Lanzi Roberto , Galeone Carlotta , Pelucchi Claudio , Pennacchioni Mario , Perticone Francesca , Sirtori Marcella , Losa Marco , Rubinacci Alessandro
Published: March 2021

Purpose: The effects of growth hormone (GH) replacement on bone mass and body composition in adult with GH deficiency (AGHD) are still debated with regard to their persistence in the long term. Moreover, the impact of gender on the response to GH is controversial. Aim of this study was to evaluate the long-term effects of rhGH replacement on bone mass and body composition in a monocentric cohort of patients with AGHD.Methods: Data from 138 patients with AGHD (34.3 ± 14.3 years, 48 women and 90 men) treated with rhGH for a period of at least 3 years up to a maximum of 10 were retrospectively collected. Bone mineral density (BMD) at the lumbar spine, femur, and radius, and total and truncular body composition were evaluated by dual energy X-ray absorption (DXA) before and during treatment. Clinical and laboratory evaluations were performed before and during the treatment period on an annual basis.Results: Lumbar spine BMD consistently increased in males, while in females decreased after a transient improvement observed during the first 4 years of therapy. There were no significant changes in femoral BMD in either sexes, while a progressive increase at radius was observed only in males. Lean mass significantly increased in both sexes, while fat mass decreased only in males.Conclusions: In AGHD patients long-term rhGH replacement therapy induces a positive effect with regard to bone mass and body composition. A sexual dimorphism in the response to treatment is evident, with males displaying more favorable outcome.
Facile Synthesis of Nanostructured Zno-rgo Based Graphene and It’s Application in Waste Water Treatment
Authors: Ramadan Rania , Abdel-Aal Seham K.
Published: March 2021

In the present work graphene oxide GO prepared by chemical exifliation of graphite using Hummer’s method. A facile and green synthesis of ZnO-rGO nanocomposite was performed via Alovera plant extract. The characterization tools (XRD-FTIR- FESEM-TEM- AFM) proved the formation of single phase of ZnO-rGO nanocomposite. Since the environmental contamination caused by Cd(II) ion is a world issue as it has a harmful effect especially on the human health and environment. Subsequently, our goal in this work is to find an accurate method for detection and adsorption of toxic Cd(II). ZnO and ZnO-rGO nanocomposites are prepared for removing Cd(II) and on behalf of increasing its removal efficiency, GO is added. The results showed a great improvement in removal efficiency reached up to 90% at pH 6 after 90 min. the structure and surface of prepared samples studied through XRD, FTIR, FESEM and AFM.
Spatiotemporal Expression Patterns of Critical Genes Involved in FGF Signaling during Morphogenesis and Odontogenesis of Deciduous Molar in Miniature Pig
Authors: Guo Wenwen , Zhang Ran , Hu Lei , Wang Jiangyi , Wang Fu , Wang Jinsong , Zhang Chunmei , Wu Xiaoshan , Wang Songlin
Published: March 2021

Background
The fibroblast growth factor (FGF) pathway plays important role in epithelial-mesenchymal interactions during tooth development. However, how the ligands, receptors, and inhibitors of the FGF pathway get involved into the epithelial-mesenchymal interactions are largely unknown in miniature pigs, which can be used as large animal models for similar tooth anatomy and replacement patterns to humans.
Results
In this study, we investigated the spatiotemporal expression patterns of critical genes encoding FGF ligands, receptors, and inhibitors in the third deciduous molar of the miniature pig at the cap, early bell, and late bell stages. With the methods of fluorescence in situ hybridization and real time RT-PCR, it was revealed that the expression of Fgf3, Fgf4, Fgf7, and Fgf9 mRNAs were located mainly in the dental epithelium and underlying mesenchyme at the cap stage. The expression levels of Fgf3 and Fgf7 in the mesenchyme were upregulated in the early bell stage and then concentrated in the odontoblasts layer in the late bell stage. In contrast, the expression levels of Fgf4 and Fgf9 in the mesenchyme were downregulated from the cap to bell stage. Gene expression analysis also suggested that Fgfr1 and Fgfr3 were the major receptors regulating dental calcification. Furthermore, the inhibitor-coding genes Sprouty 2 and Sprouty 4 were expressed in the epithelium and mesenchyme in the three stages, indicating that elaborate regulation occurred during dental morphogenesis.
Conclusions
The spatiotemporal expression pattern of FGF signaling provides the foundation for future studies aiming to fine-tune dental morphogenesis and odontogenesis by controlling the interactions between the dental epithelium and mesenchyme, thereby promoting tooth regeneration in large mammals.
Design and Analytical Evaluation of A High Resistance Sensitivity Bolometer Sensor Based on Plasmonic Metasurface Structure
Authors: Hamouleh-Alipour Abbas , Mir Ali , Farmani Ali
Published: March 2021

Bolometer sensors are prominent and excellent choice in technology because they do not need cooling. The trade-off between high sensitivity, fast response time, and strong light absorption is a key important challenge in bolometer sensors. Here, the bolometric effect for a high resistance sensitivity plasmonic sensing of total and profile infusion of radiation is studied for the proposed bolometer sensor based on plasmonic multilayer structure at 26° C. In the present study, by generating strong coupling condition between incident wave and surface plasmon polaritons (SPPs), a very narrow absorption spectra with high figure of merit (FoM) is achieved. The analytical model and numerical simulation are fulfilled based on the transfer matrix method (TMM) and 3-D finite-difference time-domain (FDTD), respectively. The narrow absorption spectra that generate by strong coupling with SPPs heats the silver thin film that leads to variation in temperature and supports TE surface mode. This temperature change rectifies the resistance of the metal thin film by the bolometric effect. So, optical characteristics of the proposed metasurface bolometer sensor, including quality factor (Q), sensitivity, and figure of merit (FoM) are calculated that Max sensitivity, FoM, and Q are 17.2 RIU-1, 530 and 434.5, respectively. Finally, we analytically simulate the temperature coefficient of resistance (TCR) in terms of wavelength and refractive index of analyte (na) that this resistance change can be monitored by an external electric model. The proposed plasmonic multilayer configuration is a very compact footprint structure that achieved high resistance sensitivity and FoM in comparison with any previous reports. This proposed thermal, optical, and electric plasmonic metasurface bolometer sensor can be used in different applications such as biophysics, biology, and environmental science.
Specific inhibition of Streptococcus bovis by endolysin LyJH307 supplementation shifts the rumen microbiota and metabolic pathways related to carbohydrate metabolism
Authors: KIM Han Been , Park Tansol , Kwon Inhyuk , Seo Jakyeom
Published: March 2021

Background: Ruminal acidosis negatively affects the animal production and performances of high-performance cattle by abnormal balancing of the rumen microbiota, which caused significant economic damage to farmers. Endolysins, the bacteriophage-originated peptidoglycan hydrolases, are a promising replacement of antibiotics due to their immediate lytic activity and no evidence of antibiotic resistance. The objectives of this study were to investigate the lytic activity of Streptococcus bovis specific endolysin LyJH307 against S. bovis and explore changes in rumen fermentation and microbiota in an in vitro system. Treatments consisted of corn grain with protein elution buffer and corn grain with endolysin LyJH307 (LyJH307, 0.2% of dietary dry matter). The rumen bacterial community was analyzed using 16S rRNA amplicon sequencing, followed by the prediction of microbial functional features by using PICRUSt2.Results: Endolysin LyJH307 supplementation at 6 h incubation time markedly decreased the absolute abundance of S. bovis (approximately 70%) and increased ruminal pH at the end of the incubation. There were no significant changes in gas production, in vitro dry matter degradability, and total volatile fatty acid production. The acetate proportion was significantly increased after LyJH307 addition, whereas propionate was decreased, thereby inducing an increase of acetate to propionate ratio in LyJH307. LyJH307 supplementation increased D-lactate without any change in L-lactate concentration. Among the alpha diversity indices, there were no significant differences in Shannon’s index, Simpson’s index, Chao1 estimates, and evenness. Based on Bray-Curtis dissimilarity matrices, the LyJH307 affected the overall shift in ruminal microbiota. Endolysin LyJH307 supplementation induced an increase of 11 genera containing Lachnoclostridium, WCHB1-41, unclassified genus Selenomonadaceae, Paraprevotella, vadinBE97, Ruminococcus gauvreauii group, Lactobacillus, Anaerorhabdus furcosa group, Victivallaceae, Desulfuromonadaceae, and Sediminispirochaeta. The predicted functional features represented by the Kyoto Encyclopedia of Genes and Genomes pathways were changed by LyJH307 toward a decrease of carbohydrate metabolism.Conclusions: Endolysin LyJH307 caused a reduction of S. bovis and an increase of ruminal pH with concomitant shifts in minor rumen microbiota and its metabolic pathways related to carbohydrate metabolism. This study provides the first insight into the availability of endolysin as a specific modulator for rumen and shows the possibility of endolysin degradation by rumen microbiota.
Ecological Effects on Female Bill Color Explain Plastic Sexual Dichromatism in A Mutually-Ornamented Bird
Authors: Freitas Rita , Marques Cristiana , Cardoso Gonçalo C. , Trigo Sandra
Published: March 2021

Sex differences in ornamentation are common and, in species with conventional sex roles, are generally thought of as fixed, due to stronger sexual selection on males. Yet, especially in gregarious species, ornaments can also have non-sexual social functions, raising the possibility that observed sex differences in ornamentation are not fixed. For example, females may invest in costly ornamentation more plastically, to protect body and reproductive ability in more adverse ecological conditions. We tested this hypothesis with experimental work on the mutually-ornamented common waxbill (Estrilda astrild), supplementing their diets either with pigment (lutein, a carotenoid) or non-pigment (vitamin E) antioxidants, or alleviating winter cold temperature. We found that both lutein and vitamin E supplementation increased red bill colour saturation in females, reaching the same mean saturation as males, which supports the hypothesis that female bill colour is more sensitive to environmental or physiological conditions. The effect of vitamin E, a non-pigment antioxidant, suggests that carotenoids were released from their antioxidant functions. Alleviating winter cold did not increase bill color saturation in either sex, but increased the stability of female bill color over time, suggesting that female investment in bill color is sensitive to cold-mediated stress. Together, results show that waxbill bill sexual dichromatism is not fixed. Instead, sexual dichromatism can be modulated, and even disappear completely, due to ecology-mediated plastic adjustments in female bill color.
Spatio-temporal analysis of droughts in the Lake Chilwa Basin, Malawi
Authors: Kambombe Oscar Clement , Ngongondo Cosmo , Eneya Levis , Monjerezi Maurice , Boyce Clement
Published: March 2021

Drought phenomena are attributed to water availability deficit that is caused by low precipitation. However, droughts are quite complex and cannot simply be defined on the basis of precipitation as other factors may have an influence. In this study, we investigated the spatio-temporal patterns of droughts in Lake Chilwa Basin, an endorheic lake basin that has recently experienced major recurrent lake recessions. The standardized precipitation index (SPI) and standardized precipitation evapotranspiration index (SPEI) at six- and twelve-month timescales were used to evaluate drought severity variations from 1970 to 2018, in relation to the recessions. The stationarity difference in rainfall between 1973 to 1995 and 1996 to 2018 and climatological trends were tested using Mann-Whitney and Mann-Kendall tests, respectively. The El Niño Southern Oscilation (ENSO) influence on rainfall was also investigated. In general, the results show a statistically insignificant decreasing rainfall trend, coupled with statistically significant temperature increase (a=0.05). In addition, both indices broadly detected droughts within similar category ranges and variation patterns, suggesting minimal influence of temperature on droughts compared to rainfall. The study also reveals that not every ENSO event leads to low rainfall in the basin. It is further shown that unlike past major recessions e.g., 1994/95, recent lake dry-ups of 2012 and 2015 were as a result of milder droughts. Moreover, the trigger threshold of lake dry-ups is shown to have shifted; such that average annual rainfall below 1000mm is likely to yield a dry-up in recent times than before, which may be attributable to anthropogenic pressure.
Embedding information into JPEG images with distortion masking in frequency domain
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Melman A. S. , Petrov P. O. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Shelupanov A. A. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Aristov A. V. ,   National Research Tomsk Polytechnic University, Pokholkov Y. P. ,   National Research Tomsk Polytechnic University
Published: March 2021

Steganography allows to ensure the confidentiality of information by organizing covert data transmission channels. However, the effectiveness of steganographic information protection directly depends on the invisibility of a secret message, both for the human eye and for steganalysis methods. The paper proposes an approach that allows solving the problem of vulnerability of the popular QIM embedding method to statistical steganalysis. For this, it is proposed to use a variable quantization step, which is adaptively selected for each block of the JPEG cover image. The experimental results demonstrate an increase in the security level of steganographic embedding due to the application of the proposed approach.
Social media event data analysis
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Kataev M. Yu. , Orlova V. V. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: March 2021

Social media analysis has become ubiquitous at a quantitative and qualitative level due to the ability to study content from open social networks. This content is a rich source of data for the construction and analysis of the interaction of social network users when forming various groups, used not only for statistical calculations, social areas of analysis, but also in trade or for the development of recommendation systems. The large number of social media users results in a huge amount of unstructured data (by time, type of communication, type of message and geographic location). This article aims to discuss the problem of analyzing social networks and obtaining information from unstructured data. The article discusses information extraction methods, well-known software products and datasets.
Algorithm for reducing additional losses in asynchronous electric drives in plants with static power regulators
Authors:   Voronezh State Technical University, Khaychenko I. A. , Babenko V. V. ,   Voronezh State Technical University, Nefedov Yu. V. ,   Voronezh State Technical University, Ha Anh. Tu. ,   Voronezh State Technical University
Published: March 2021

The ways to reduce losses of electrical energy in power supply systems of industrial enterprises containing powerful semiconductor converters and asynchronous motors are considered. The source of additional electric power losses related to subharmonic nature of voltage fluctuations from operation of converters using the principle of frequency-pulse control is determined. The operation algorithm for thyristor switches of semiconductor converters is proposed, that provides reduction of electric power losses in asynchronous motors connected in parallel with powerful converters. The voltage graphs and currents of simulation model in operation modes of converters show the potential to increase energy efficiency of operation of a wide range of industrial objects with asynchronous motors, connected in parallel and having cyclically changing load.
Formononetin Production by Large-Scale Cell Suspension Cultures of Medicago sativa L.
Authors: AKTAŞ Tayfun , ÇÖLGEÇEN Hatice , ATAR Havva
Published: March 2021

In this study, calli of Medicago sativa L. cv. Elçi (alfalfa Elçi) were inoculated in cell suspension culture and analyzed for aggregate assay, cell viability test, total phenolic content assay, DPPH free radical scavenging activity and formononetin assay by means of High-Performance Liquid Chromatography (HPLC). Hypocotyl, cotyledon and apical meristem explants were taken from 15-day-old aseptic seedlings and germinated in MS medium. 10 g calli were grown for each explant and then transferred into cell suspension culture. The highest cell viability rate, which was 75%, and the highest DPPH free radical scavenging activity with 51.36% was measured in 1000 mL cell suspension culture, while the highest total phenolic content, i.e. 40.2 mg/g, was quantified in 250 mL cell suspension culture. In accordance with the findings of the study, the production of formononetin was higher in the calli derived from cell suspension cultures than in herb samples of M. sativa. Moreover, in 1000 mL cell suspension culture, 4.99 mg/g of formononetin concentration was quantified, which scored the highest. In large-scale cell suspension cultures of M. sativa, it was possible to increase the production of formononetin production. Hence, due to its medicinal significance, a method has been tested to obtain higher amounts of this compound.