bluuebunny/crossref_metadata_2025 huggingface dataset:
EMERGING FRONTIERS: ADVANCEMENTS IN BIO-NONMATERIAL’S AND NON-INVASIVE STRATEGIES FOR COMBATING CANCER THROUGH PHOTO THERMAL THERAPY
Authors: S. YOKESH , R. TEEJESWARI , V. JALANIY , R. LOKESHVAR
Published: September 2024

Cancer remained a global health challenge in 2020 and claimed approximately 10 million lives, thus rendering it the main reason for demise. Photo Thermal Therapy (PTT) has emerged as a promising approach among the various cancer therapies. PTT offers several advantages over traditional treatments such as surgery, chemotherapy, and Radiotherapy due to its precise tumor targeting and reduced damage to healthy tissues. Photo Thermal Agents (PTAs) are central to PTT and selectively kill cancer cells by converting near-infrared light into heat. However, some PTAs exhibit toxicity and remain in the body's Reticulo Endothelial System (RES), limiting their clinical utility. To address this issue, scientists are looking at putrescible nano-photothermal compounds. This study talks about the effects of PTT and other cancer treatment techniques on patient health, stares at the process beneath PTT, and highlights recent bio-nonmaterial’s utilized in PTT. It also looks at how low temperatures and brightly coloured light might be used to improve PTT efficacy.
BRINZOLAMIDE-LOADED ETHO-LECIPLEX FOR EFFECTIVE OCULAR MANAGEMENT OF GLAUCOMA: D-OPTIMAL DESIGN OPTIMIZATION AND IN VIVO EVALUATION
Authors: EL-HELALY SARA NAGEEB , HAMMOODI HAYDER A. , TADROS MINA I. , ELKASABGY NERMEEN A.
Published: September 2024

Objective: Brinzolamide (BRZ) is an active carbonic anhydrase inhibitor adopted for glaucoma management. The limited aqueous solubility of the drug restricts its potential for ocular administration. Therefore, the aim of this investigation was to design a nanocarrier system called Etho-Leciplex (Etho-LPs) for the delivery of BRZ.
Methods: Etho-LPs were fabricated by a simple one-step technique and then optimized by D-optimal design employing Phospholipon®90G (PC): surfactant ratio and surfactant type (Cetyl Trimethyl Ammonium Bomide (CTAB) and Searylamine; SA) as independent variables, whereas the dependent variables were Entrapment Efficiency (EE%), Particle Size (PS), Polydispersity Index (PDI), and Zeta Potential (ZP). Design Expert® statistically suggested the optimum Etho-LP, which consisted of PC: Surface Active Agent (SAA) molar ratio (X1) of 1:1.27 and mixture of CTAB and SA (X2) in 1:1 molar ratio.
Results: The optimum Etho-LPs particles had spherical morphology, and EE% of 91.12±0.2 %, PS of 76.21±1.21 nm, PDI of 0.421±0.001 and ZP of 35.88 ±0.10 mV. The in vitro release study results demonstrated that BRZ is rapidly liberated from the optimum Etho-LPs compared to BRZ-suspension. Further, the optimum Etho-LP showed good mucoadhesive properties besides potential safety on rabbits’ eyes tissues. The optimum Etho-LP was found to enhance the ocular bioavailability of the drug in rabbits’ eyes relative to the BRZ suspension. In addition, histopathological assessment indicated the safety of BRZ-loaded Etho-LPs.
Conclusion: Overall, the obtained outcomes indicated the effectiveness of employing Etho-LPs for the treatment of glaucoma.
FORMULATION AND EVALUATION OF ETODOLAC AND TRIAMCINOLONE ACETONIDE LOADED NANO LIPID CARRIER GELS FOR THE THERAPEUTIC MANAGEMENT OF OSTEOARTHRITIS PAIN THROUGH TOPICAL ADMINISTRATION: A COMPARATIVE STUDY
Authors: CHAKRABORTY SOUVIK , GUPTA N. VISHAL , JAIN VIKAS , V. BALAMURALIDHARA
Published: September 2024

Objective: The present study aims to prepare carbopol-based hydrogels loaded with Etodolac (EDT), and Triamcinolone Acetonide (TCA) incorporated Nanolipid Carriers (NLCs) (EDTg and TCAg) to compare the efficacy and potency of both drugs for Osteoarthritis (OA) pain management.
Methods: EDT-NLCs and TCA-NLCs were prepared with the help of the solvent evaporation method after screening the lipids, and the NLCs were optimized. The optimized NLC formulations EDT-NLC and TCA-NLCs were examined for particle size, PDI, zeta otential, Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD), Transmission Electron Mcroscopy (TEM) and in vitro release. The prepared EDTg and TCAg have been evaluated with in vitro drug release, ex-vivo skin permeation, and in vivo pharmacokinetic and pharmacodynamic parameters.
Results: DSC and PXRD graphs showed a decrease in melting point and the amorphous form of the optimized NLC formulation. Different evaluation tests revealed that the EDT-NLCs and TCA-NLCshad particle size of 161±0.0021 nm and 167.4±0.0010 nm, PDI of 0.148±0.023 and 0.130±0.01, and zeta potential of-14 mV and-15 mV respectively, indicating their distinct nature. In vitro drug release study, ETDg showed 89.84±1.71 % release, while TCAg released 94.75±1.79 % after 24 h of application. ETDg permeated 86.5±1.68% of EDT-NLCs through the dorsal skin, compared to TCA-NLCs 76.5±1.13 %in an ex vivo skin permeation investigation. A pharmacokinetic study identified 76.3±1.98 % of EDT-NLCs and 63.25±2.003 of TCA-NLCs in drug plasma. Pharmacodynamic characteristics like X-ray analysis, Immuno Histochemistry (IHC), and histopathology indicated that EDTg and TCAg managed OA pain. All evaluation tests carried out in this research showed that formulated hydrogels could manage OA.
Conclusion: The results suggested in this research prove EDTg to have a higher potentiality than TCAg for the management of OA pain
COMBINING LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY (LC-MS/MS) TECHNIQUE, SPECTROPHOTOMETERVALIDATION AND AN IN SILICO STUDY OF 96% ETHANOL EXTRACT OF SPIRULINA PLATENSIS
Authors: SUSANTININGSIH TIWUK , FADILAH FADILAH , PRIJANTI ANI RETNO , HARDIANY NOVI SILVIA
Published: September 2024

Objective: This study was to analyze the component sofa 96% ethanol extract of Spirulina platensis by the LC-MS/MS technique, then validate them with the spectrophotometer technique using the C-phycocyanin standard and an in silico study approach as an antioxidant property of S. platensis against inflammatory.
Methods: Chromatographic resolution was attained with a Phenominex C18 (50 mm×2.6 mm, 3 µm) stationary column technique, validation using C-phycocyanin standard using the spectrophotometer technique, and an in silico study of c-phycocyanin using molecular docking analysis.
Results: Tentative active compounds such as flavonoid (Maltol and Morin), peptide (Cyclo Pro-Ala, Cyclo Pro-Pro, and Thymine), and phenol (m-Aminophenol, N-Methyltyramine, and Tyramine) have been identified from a 96% ethanol extract of S. platensis by LCMS/MS analysis. The concentration of c-phycocyanin in the 96% ethanol extract of S. platensis is 229, 2µg/ml. According to our in silico study, c-phycocyanin demonstrates potential as an anti-inflammatory agent.
Conclusion: The LC-MS/MS technique can detect flavonoid, peptide, and phenolic components in the 96% ethanol extract of S. platensis. A spectrophotometer can identify the validation equation of c-phycocyanin in a 96% ethanol extract of S. platensis. Based on our in silico study, c-phycocyanin demonstrate the capability to prevent inflammatory activity.
NAVIGATING NITROSAMINES: ORIGIN, DETECTING, ANALYSING AND REGULATING IMPURITIES IN PHARMACEUTICALS
Authors: SONAWANE TEJAS SANJAY , PAINGINKAR TANVI , BAVADIA RUCHIR , VASANTHARAJU SG , SATHYANARAYANA MUDDUKRISHNA BADAMANE , RAVI GUNDAWAR
Published: September 2024

N-nitrosamines are carcinogenic impurities mostly found in groundwater, treated water, foods, beverages, and consumer products like processed meats, alcoholic beverages, cosmetics, and cigarette smoke. The recent discovery of N-nitrosamines in pharmaceutical products and subsequent recalls pose a significant health risk to patients. Nitrosamine impurities in drug products have appeared as a critical concern in pharmaceuticals prompting extensive scrutiny from regulatory agencies and stakeholders. To avoid carcinogenic and mutagenic effects in patients relying on these medications, authorities have established specific guidelines in risk assessment scenarios and proposed control acceptable limits for nitrosamine impurities in pharmaceuticals. This review provides an information on historical background of Nitrosamine impurities; its carcinogenic effect; the sources and formation of impurities; associated risks of nitrosamines in drug formulations; different analytical techniques for nitrosamine detection. It also gives an understanding of the general Quality Risk management (QRM) process, techniques for measuring nitrosamine impurities with control strategies as directed by the regulatory authorities and how to avoid them in pharmaceutical drug products. A brief review on recalls of drug classes including angiotensin II receptor antagonists, histamine-2 receptor antagonists, antimicrobial agents, and antidiabetic drugs by regulatory bodies due to its potential harm produced by nitrosamine have been discussed. Moreover, the regulatory landscape governing nitrosamine impurities are explored, encompassing recent guidelines from major regulatory bodies such as the United States Food and Drug Administration (USFDA), European Medicines Agency (EMA) and Health Canada (HC) in controlling/eliminating the nitrosamine impurities in pharmaceuticals.
ANALYTICAL QUANTIFICATION OF BOSUTINIB IN NANOCARRIER USING UV AND HPLC: METHOD DEVELOPMENT AND VALIDATION
Authors: AGADE RISHABH , HUSSAIN UJBAN , TRIVEDI SAGAR , BELGAMWAR VEENA
Published: September 2024

Objective: Bosutinib, a potent tyrosine kinase inhibitor, holds significant promise in cancer therapy, particularly in Breast Cancer treatment. This study focuses on the analytical quantification of Bosutinib in Nanocarriers (BNCs) essential for quantification in terms of targeted delivery.
Methods: A comprehensive method development and validation process was undertaken utilizing UV-visible spectroscopy and High-Performance Liquid Chromatography (HPLC). Preformulation studies confirmed the purity and physicochemical properties of bosutinib. UV-visible spectroscopy established a calibration curve for bosutinib and BNCs, with precision, accuracy, Limits of Detection (LOD), and Limits of Quantification (LOQ) determined. HPLC analysis further validated bosutinib quantification, ensuring the robustness and reliability of the analytical method.
Results: Bosutinib and BNCs were evaluated using UV-visible spectroscopy, revealing λ max at 263 nm and 277 nm, respectively, showing a strong correlation with the regression coefficient (R2) being 0.9969 and 0.9994, respectively. The precision (intra-day and inter-day) data shows strong reproducibility with a Percentage Relative Standard Deviation (%RSD) of less than 1.5%. Completely distinguished sharp peaks of bosutinib and BNCs were developed using HPLC under ambient settings; 3.974±0.006 and 3.083±0.004 was the Resolution Time (Rt) at which bosutinib and BNCs were discovered, respectively. The Theoretical Plate (TP) values of 5179±93 and 2598±85 and the Tailing Factor (TF) of1.00±0.002 and 1.10±0.004 were both within the predetermined bounds.
Conclusion: The developed UV and HPLC methods offer accurate and reliable quantification of bosutinib in a nanocarrier, essential for optimizing drug delivery strategies and therapeutic outcomes in cancer treatment. This analytical approach contributes to advancing pharmaceutical research in precision medicine and targeted drug delivery systems.
FORMULATION AND EVALUATION OF LICORICE OIL-BASED EMULGEL FOR THE TREATMENT OF PSORIASIS
Authors: JUREL PRIYANKA , BAHADUR SHIV , BAJPAI MEENAKSHI
Published: September 2024

Objective: The aim of the present research work was to develop and evaluate the topical emulgel incorporated with licorice oil for the effective management of psoriasis.
Methods: The present study involves the preparation and optimization of licorice oil-based emulsion using tween 80, span 20, propylene glycol and was loaded in gel base (carbopol 940 was used as gelling agent). The prepared emulgel were evaluated for various parameters such as particle size, zeta potential, entrapment efficiency, spreadibility, pH, viscosity, Fourier-Transform Infrared Spectroscopy (FTIR), in vitro release studies and in vitro cell line study.
Results: The optimized formulation was found to have droplet size of 54.50 nm,-14.1 V zeta potential, entrapment efficiency of 59.53±8.42 % and spreadibility of 2.901±0.12 mm. The pH and viscosity of optimized licorice oil-based emulgel was found to be 6.0±0.467 and 93,500±832 cps, respectively. Cumulative in vitro release was found to be 95.15±0.26 % has shown by the optimized formulation for 10 h. In (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT cytotoxicity study indicated non-toxic potential properties of licorice oil and its emulgel at lower level and caused moderate toxicity at higher level against Human Epidermal Keratinocytes (HaCaT) cell lines after the incubation period of 24 h respectively.
Conclusion: This study showed that the emulgel formulation has the potential to significantly enhance the efficacy of licorice oil in the treatment of psoriasis. These findings provide exciting new possibilities for improving psoriasis treatment and explores importance of continued research in this area.
INVESTIGATING MULTITARGET POTENTIAL OF MUCUNA PRURIENS AGAINST PARKINSON'S DISEASE: INSIGHTS FROM MOLECULAR DOCKING, MMGBSA, PHARMACOPHORE MODELLING, MD SIMULATIONS AND ADMET ANALYSIS
Authors: FATHIMA C. ZAKIYA , JAMES JAINEY P. , SRINIVASA MAHENDRA GOWDRU , T. J SINDHU , B. M. MARIYAM JOUHARA , REVANASIDDAPPA B. C. , D. GHATE SUDEEP
Published: September 2024

Objective: Mucuna pruriens (Velvet beans) is a leguminous plant recognised in Vedic therapy as an anti-Parkinsonism agent. The plant is known as the natural reservoir for levodopa. The study aims to evaluate the multitarget inhibitory potency of active constituents present in Mucuna pruriens using in silico tools.
Methods: The phytoconstituents present in Mucuna pruriens were retrieved from the IMPPAT database. The physicochemical and toxicity parameters of phytoconstituents were evaluated using Qikprop and ProTox-3. The inhibitory potential of phytoconstituents on the enzymes Monoamine Oxidase-B (MAO-B), Acetylcholinesterase (AChE), and Catechol-O-Methyltransferase (COMT) was evaluated using in silico techniques, including molecular docking, pharmacophore modelling, and molecular dynamics simulations, conducted with Schrödinger software programs.
Results: The active constituents comply with Lipinski’s rule for drug-likeness. Further, the molecular docking studies revealed the phytoconstituent luteolin and acacetin showed promising multitargeted inhibitory properties. Especially luteolin (-11.504 kcal/mol) and acacetin (-10.620 kcal/mol) have obtained excellent docking scores with MAO-B, whereas the known drug levodopa showed a docking score of-8.501 kcal/mol. The pharmacophore modelling revealed that donor, acceptor, and aromatic features present in luteolin and acacetin are the essential pharmacophoric features accountable for biological activity. The simulation study generated the stability of the protein-ligand complex and found that luteolin showed a stable complex with MAO-B.
Conclusion: Based on these findings, the result of the current study can be used to develop a novel luteolin-based drug for treating Parkinson’s disease with preferred structural modification. However, additional and more comprehensive research is required on this compound.
HESPERETIN DERIVATIVES AS PPAR γ AGONIST: A PHARMACOPHORE APPROACH
Authors: MUTHIAH RAMANATHAN , CHINNIAH VIJAYALAKSHMI , ENGELS. S. E. MAIDA
Published: September 2024

Objective: The study focuses on enhancing the pharmacological activity of hesperetin, a bioflavonoid, to develop novel derivatives with improved efficacy and reduced side effects compared to existing Thiazolidinediones (TZDs) as PPAR g agonist.
Methods: The Methodology involves various computational approaches, including pharmacophore modelling, molecular docking, Molecular Mechanics with Generalised Born and Surface Area Solvation (MMGBSA), and molecular dynamics simulations. Pharmacophore modelling identifies essential binding features validated by Quantitative Structure-Activity Relationship (QSAR) models. Database screening and docking confirm lead compounds' binding affinity, with MMGBSA aiding lead optimization. Toxicological assessment ensures drug likeness and bioavailability. Molecular dynamics simulations explore protein-ligand complex stability and dynamics, revealing insights into their interactions.
Results: The results indicate MOL-297 exhibits improved properties over hesperetin, including ADME properties, solubility, blood-brain barrier permeability, docking score, and binding energy. Molecular dynamics simulations confirm Mol-297-PPAR γ complex stability, with favourable ligand-amino acid interactions.
Conclusion: The developed new molecule MOL 297, is a novel Peroxisome Proliferator-Activated Receptor (PPAR) gamma agonists with enhanced pharmacological properties, warranting further experimental validation and drug development.
QUANTITATIVE DETERMINATION OF METHYL-4-CHLOROBUTYRATE, A POTENTIAL GENOTOXIC IMPURITY, CONTENT IN MOXIFLOXACIN HCL BY GC-EI-MS
Authors: APARNA K. , RACHEL K. VIJAYA , RAO K. M. V. NARAYANA
Published: September 2024

Objective: Methyl-4-Chlorobutyrate (M4CB), a genotoxic impurity, was identified in the active pharmacological components of the fourth-generation fluoroquinolone, moxifloxacin (MXFN). There has not yet been a report on the analysis of the M4CB impurity content in the MXFN molecule. Consequently, a Gas Chromatography-Electron Ionization-Mass Spectrometry (GC-EI-MS) method was established that has the ability to identify and measure M4CB impurity content at ppm level.
Methods: The column exploited in M4CB impurity assay was a Dura Bond 624 (DB-624) type stationary column. Temperatures of 220 °C and 280 °C were consistently maintained at the injection and detection sites, respectively. The helium, as carrier gas, in split mode with ratio of 1:7 was used. The column's flow rate remained steady around 2.0 ml/min. The mass spectrometer was operated in Single Ion Monitoring (SIM) mode at m/z = 74.
Results: The impurity M4CB is generated during the manufacturing process of cyclopropanamine, which is an intermediary molecule in the manufacturing process of MXFN. This new GC-EI-MS approach can measure the M4CB at 0.9452 ppm in MXFN samples with a 500 mg/ml concentration following International Council for Harmonisation (ICH) standards. Very low quantification limits (0.9452 ppm), high linearity (range=0.945 ppm to 5.625 ppm; regression coefficient= 0.9999), and a reasonable recovery range (94.60-94.63%) were all provided by this new validated GC-EI-MS approach. Three batches were analysed for M4CB content by new GC-EI-MS approach and found that none of the batches contained M4CB impurity.
Conclusion: The GC-EI-MS approach has excellent applicability in the quality assurance testing of MXFN for M4CB content since it was adequate in terms of linearity, precision, sensitivity, accuracy, specificity, and robustness.
SYNTHESIS, CHARACTERIZATION AND IN VITRO EVALUATION OF VATERITE MICROPARTICLES
Authors: JOSE DEENA , KUMUDHA D.
Published: September 2024

Objective: The aim of this research is to synthesize submicron-sized calcium carbonate vaterite particles of elliptical shape with different reaction durations. We also aim to assess their antioxidant and anti-inflammatory properties, which may be beneficial for treating diseases such as asthma and rheumatoid arthritis.
Methods: Calcium carbonate vaterite particles were prepared using the co-precipitation method with varying reaction times, characterized by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier Transformation Infrared Spectroscopy (FTIR), and Poly-Dispersity Index, with antioxidant activity assessed by the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method and anti-inflammatory activity by the protein denaturation method.
Results: SEM and TEM analysis revealed that the synthesized vaterite particles had an elliptical shape with nano-crystalline particles of around 50 nm size. FTIR verified the production of vaterite particles. Research on antioxidants and anti-inflammatory agents revealed that the crystalline particles exhibited DPPH scavenging action, with an IC50 of 12.6 µg/ml, and a noteworthy reduction in protein denaturation in the albumin protein denaturation test, with an IC50 of 222.49 µg/ml, in comparison to the reference value.
Conclusion: The results highlight the potential of elliptical vaterite submicron micro-particles as versatile platforms with anti-inflammatory and antioxidant properties, paving the way for future advancements in drug delivery systems, food additives, and natural supplements by efficiently encapsulating drugs and proteins.
DIAGNOSTIC AND THERAPEUTIC ROLE OF MESOPOROUS SILICA NANOPARTICLES IN COMBATING CANCER
Authors: KATARIYA NUPUR , FARSWAN ARVIND SINGH , NAINWAL NIDHI , KUMAR GANESH
Published: September 2024

Cancer is a global health problem of human beings that is growing day by day despite several advancements in the medical field. The main concern of cancer treatment is the timely and proper diagnosis of this disease and the targeting of therapeutic moieties to the cancer site. Nanotechnology has emerged as a boon for the healthcare system in treating various life-threatening diseases. Mesoporous Silica Nanoparticles (MSNs), have drawn interest in the diagnosis and treatment of cancers and various other diseases. MSNs can be easily adjusted to specifically target cancer cells, improve drug targeting and minimize the undesirable effects. In the imaging and diagnosis of cancer, MSNs can be altered with imaging agents or used as contrast agents in imaging techniques like Magnetic Resonance Imaging (MRI) and Computed Tomography (CT). MSNs can be used to deliver different types of therapeutic molecules alone or in combinations to provide a synergistic effect in eradicating cancer. The current review focused on highlighting the role of MSNs in combating cancer. In addition, the biodegradation, clearance and toxicity profile of MSNs is explained to evaluate their suitability for clinical applications.
Competition of Narratives: Deciphering the Debates on Research at Universities of Applied Sciences in Austria
Authors:   FH Oberösterreich, Hochschulforschung und -entwicklung, Universität Wien, Institut für Wissenschafts- und Technikforschung, Sterrer Stefanie
Published: September 2024

Research at Austrian universities of applied sciences (UAS) is often characterized as practice-oriented and directly applicable, yet it is also criticized as amateurish or trivial. Despite the varied reality of research activities, dominant narratives shape public perceptions of UAS research and influence debates about its identity, quality, and legitimacy. This article, based on a comprehensive document analysis, explores why research at Austrian universities of applied sciences has remained controversial over the past three decades. It identifies two main narratives: one that views UAS as institutions primarily focused on teaching rather than research, and another that regards UAS research as a significant contributor to innovation and regional development. These narratives are intertwined with broader discourses on higher education and scientific knowledge production. Drawing on insights from higher education studies and science and technology studies, this article examines how these narratives reflect and perpetuate competing social norms and ideologies. The coexistence of these narratives in public discourse highlights underlying power dynamics and social inequities, compelling stakeholders, including UAS administrators and researchers, to navigate conflicting expectations regarding UAS research. By delineating these narratives, situating them within broader discursive frameworks, and acknowledging their simultaneous existence, this article enhances our understanding of the ongoing debate surrounding UAS research. It underscores the importance of engaging with the complexities of this discourse rather than dismissing it, as it is crucial to broader discussions about the value of academic research and the role of universities in advancing research and innovation.
Mangles al rescate: cómo estos árboles purifican ecosistemas costeros
Authors: Pérez Hernández Victoria Sabrina , Millán Aguilar Olivia Guadalupe , Manzano Sarabia Mercedes Marlenne , Hurtado Oliva Miguel Ángel , Osuna Martínez Carmen Cristina
Published: September 2024

El acelerado crecimiento de la población humana en las últimas décadas ha llevado a un aumento en la tecnificación industrial, generando grandes cantidades de contaminantes, como aguas residuales, desechos sólidos y emisiones gaseosas. Estos contaminantes, al no recibir un tratamiento adecuado, pueden dañar el ambiente y la salud humana. Para mitigar estos efectos, se han desarrollado estrategias como la biorremediación, que emplea organismos como bacterias, hongos, algas y plantas para rehabilitar entornos contaminados por metales pesados, hidrocarburos, pesticidas y plásticos. Aunque no es una tecnología nueva, su continua actualización a través de la investigación y la incorporación de nuevos organismos específicos para cada ecosistema es crucial. Una estrategia prometedora es el uso de mangles, plantas altamente tolerantes a altas temperaturas y salinidad, que muestran un gran potencial en la biorremediación de ecosistemas costeros contaminados por metales pesados.
Importance of Yoga in Educational Field
Authors: C Girisha
Published: September 2024

The evolution of education in India mirrors the shifting needs and values of society over time. This thesis examines the transition from the ancient Gurukula system, which prioritized holistic development, to the contemporary education model that emphasizes academic achievement and structured learning. It underscores the importance of integrating practices such as yoga into the modern education system to alleviate the increasing pressures on students and to promote their overall well-being. The ancient Gurukula system was fundamentally based on a strong teacher-student relationship, fostering the development of the mind, body, and spirit. Beyond academic instruction, students learned life skills, moral values, and disciplined living, with yoga playing a central role in enhancing mental clarity, physical fitness, and spiritual growth. In contrast, the modern education system, though more widely accessible, often overlooks the importance of mental and physical health in its focus on academic achievement. This oversight has led to increased stress and pressure on both students and teachers, highlighting the need for more holistic educational approaches. To address these challenges, this thesis advocates for the integration of yoga into the modern education system as a means to improve students' mental and physical well-being. In response, a Recommended Yoga Protocol for Children (6-12 Years) has been developed, featuring a 35-minute daily yoga practice designed for school settings. This protocol incorporates asanas (postures), pranayama (breathing techniques), and relaxation exercises aimed at enhancing focus, reducing stress, and improving physical health among children. A key aspect of the research was a comparative study titled "Survey of 50 Students of Age Group 6-12: A Comparative Study Before and After Yoga Implementation," conducted in Turuvekere Taluk, Tumkur District. This study involved 50 students aged 6-12 years and aimed to assess the impact of the yoga protocol on their academic performance, concentration, and overall wellbeing. Pre- and post-implementation assessments were used to evaluate changes in physical fitness, mental alertness, and academic performance
Quasi-Contract: A Comparative Analysis Between the United States of America and Indonesia
Authors: Sibarani William , Puspaningsih Utami , Stefanie Clarita
Published: September 2024

Since the Roman era, there has been a general consensus that no one should prosper at the expense of another. However, the development of variations in legal systems in the world means that many countries must continue to adapt to this situation to avoid legal loopholes. In certain situations, the complexity of obligations in society causes quasi-contracts to occur. As a country that follows the civil law constitutional framework, Indonesia still encounters difficulties in handling quasi-contract disputes, not only due to the absence of written regulations but also because previous court decisions do not bind Indonesia. In contrast, in the United States of America, the creation of law occurs through court decisions. However, this study also aims to deliver insight into the legal systems' orientations in those two nations and how they relate to restorative justice. Hence, the author will discuss how quasi-contract problems are resolved by explaining the comparison between the two legal systems. This study uses a comparative juridical method to analyze the judgment practices on quasi-contracts between the United States of America and Indonesia and recommends the urgency of issuing regulations to address these disputes.
The Fractal-Lattice Hubbard Model
Authors: Conte Monica , Zampronio Vinicius , Röntgen Malte , Smith Cristiane Morais
Published: September 2024

Here, we investigate the fractal-lattice Hubbard model using various numerical methods: exact diagonalization, the self-consistent diagonalization of a (mean-field) Hartree-Fock Hamiltonian and state-of-the-art Auxiliary-Field Quantum Monte Carlo. We focus on the Sierpinski triangle with Hausdorff dimension 1.58 and consider several generations. In the tight-binding limit, we find compact localised states, which are also explained in terms of symmetry and linked to the formation of a ferrimagnetic phase at weak interaction. Simulations at half-filling revealed the persistence of this type of magnetic order for every value of interaction strength and a Mott transition for U/t ∼ 4.5. In addition, we found a remarkable dependence on the Hausdorff dimension regarding i) the number of compact localised states in different generations, ii) the scaling of the total many-body ground-state energy in the tight-binding limit, and iii) the density of the states at the corners of the lattice for specific values of electronic filling. Moreover, in the presence of an intrinsic spin-orbit coupling, the zero-energy compact localized states become entangled and give rise to inner and outer corner modes.
Mujeres en la música: ejecución de repertorio de compositoras en la escena musical académica costarricense
Authors: Miranda-Gutiérrez Noelia
Published: September 2024

El presente artículo es el resultado de una búsqueda exploratoria en torno a la ejecución de repertorio realizado por compositoras académicas en Costa Rica desde finales del siglo XIX hasta la actualidad. El objetivo de esta investigación es contribuir a la reivindicación histórica de las compositoras académicas ante la continua invisibilización de este repertorio en el país. El estudio se delimita espacialmente en las salas de concierto ubicadas en el Valle Central, ya que durante estos siglos es donde se registra la principal concentración de reproducción de obras musicales académicas en Costa Rica. El artículo incluye revisión bibliográfica, seis entrevistas a mujeres profesionales en la música, quienes compartieron sus testimonios acerca de su experiencia con el repertorio académico compuesto por mujeres, además, se realizaron consultas directas en archivos históricos para identificar la presencia o ausencia de este repertorio en el país. Todas estas fuentes permiten, a su vez, generar un primer registro de obras musicales y compositoras académicas que han pasado por las salas de concierto de Costa Rica desde las precursoras a finales del siglo XIX hasta las compositoras contemporáneas. Este registro evidencia cómo, a pesar de las resticciones patriarcales que ha caracterizado la composición y el canon musical, las mujeres han estado presentes con sus obras en todos los siglos explorados para el artículo.
Reporte de caso: Cirugía oncológica de la presentación intraocular de un tumor venéreo transmisible en perro
Authors: Mesa Truque Juan Diego , Martínez Alvarado Ingrith Maritza , Pedraza Castillo Luz Natalia
Published: September 2024

El tumor venéreo transmisible (TVT), es una neoplasia contagiosa de distribución mundial, que se propaga sexualmente en la mayoría de los casos y se caracteriza por producir lesiones primarias sobre los genitales, sin embargo, también puede manifestarse en áreas extra-genitales. El presente reporte  tiene como objetivo describir el caso de un paciente canino macho, mestizo, de dos años y medio de edad, quien acudió al Centro Clínico Veterinario de la Universidad de los Llanos por un cambio en el color y aumento de tamaño del ojo derecho. Además, la propietaria menciona que su mascota fue diagnosticada con TVT en otro centro clínico hace 8 meses, donde recibió tratamiento. Se realizó enucleación del globo ocular como tratamiento quirúrgico, y posteriormente, tras confirmar el diagnóstico de TVT mediante histopatología, se inició tratamiento quimioterapéutico con vincristina a una dosis de 0,025 mg/kg. Luego del proceso quirúrgico y las sesiones de quimioterapia, el paciente se recupera satisfactoriamente.
Memorias V Encuentro de Investigadores Facultad de Ciencias Agropecuarias y Recursos Naturales Universidad de los Llanos
Authors: Agropecuarias y Recursos Naturales Facultad de Ciencias
Published: September 2024

La Facultad de Ciencias Agropecuarias y Recursos Naturales, con el apoyo de los grupos de investigación en: Biotecnología y Toxicología Acuática y Ambiental – BioTox, Innovación en sistemas agrícolas y forestales – ISAF, Ciencia, tecnología e innovación agroindustrial – CITIA, Farmacología Experimental y Medicina Interna – Élite, Patología de Animales Domésticos y Fauna Silvestre – GRIPADS realizaron  el V  Encuentro  de  Investigadores  de  la Facultad  de  Ciencias  Agropecuarias  y  Recursos  Naturales durante el 21 y 22 de noviembre   del   2023   en   el   Auditorio   Eduardo   Carranza,   sede   Barcelona  de   la Universidad de los Llanos, Villavicencio, Meta, Colombia. El Encuentro de Investigadores de la FCAyRN, es un evento académico que se ha realizado desde el año 2013 y que tiene como objetivo general divulgar y socializar los resultados de los procesos de investigación de la Facultad de Ciencias Agropecuarias y Recursos Naturales de la Universidad de los Llanos, enmarcadas en las cinco líneas de investigación de la FCAyRN, así:
 

Salud Animal, Agrícola y Ambiental

Producción Agraria

Desarrollo Rural y Territorial

Sistemas de Producción Agroindustrial

Recursos Hidrobiológicos
Polityka finansowa wybranych gmin województwa warmińsko-mazurskiego
Authors: Pomianek Iwona
Published: September 2024

Możliwości inwestycyjne samorządów lokalnych, stanowiące istotny czynnik rozwoju obszarów wiejskich, są w dużym stopniu uwarunkowane z jednej strony samodzielnością dochodową i wydatkową samorządów, a z drugiej – aktywnością w zakresie aplikowania o środki z funduszy Unii Europejskiej. Wysoka samodzielność finansowa i aktywność cechowała gminy o wyższym poziomie rozwoju, według miernika rozwoju społeczno-gospodarczego Hellwiga. Z drugiej strony – gminy wiejskie oddalone od aglomeracji miejskich, o niższym poziomie rozwoju, cechowała bierność w aplikowaniu o dofinansowanie projektów, których realizacja właśnie tam byłaby najbardziej potrzebna
Publiczny system finansowy w gospodarce rynkowej
Authors: Waściński Tadeusz , Wójcik Grażyna
Published: September 2024

W pracy omówiono zasady funkcjonowania publicznego systemu finansowego, koncentrując się na jego zadaniach oraz specyficznych właściwościach. Stwierdzono, że publiczny system finansowy w Polsce jest ciągle w okresie przeobrażeń dokonywanych w różnych płaszczyznach funkcjonowania
Zarządzanie finansami jednostek samorządu terytorialnego na przykładzie gminy
Authors: Wyrębek Henryk
Published: September 2024

Funkcjonow?nie jednostek s?morządu terytori?lnego j?wi się j?ko problem wielkiej w?gi t?k dl? c?łego społeczeństw?, j?k i poszczególnych jednostek. J?kość or?z rozmi?r re?lizow?nych z?d?ń są funkcją posi?d?nych z?sobów, ? zwł?szcz? ich efektywnego wykorzyst?ni?. Zmi?ny w filozofii z?rządz?ni? fin?ns?mi dotyczą wszystkich jednostek s?morządowych dzi?ł?jących w obecnej rzeczywistości gospod?rczej. Z?soby finansowe są szczególnym z?sobem, ? procesy związ?ne z ich grom?dzeniem i wyd?tkow?niem są nie tylko interesujące, lecz t?kże wym?g?ją szczegółowego spojrzeni? i szczególnej?n?lizy. W artykule zaprezentowano zarządzanie finansami samorządu terytorialnego na przykładzie Gminy Grodzisk
Uwagi na temat kryzysu gospodarczego i sektora bankowego w Polsce
Authors: Piocha Stanisław , Radlińska Kamila
Published: September 2024

Obecny kryzys gospodarki globalnej uwidocznił niedoskonałości funkcjonowania rynków globalnych. Znaczny poziom integracji ekonomicznej, silne międzynarodowe współzależności spowodowały przeniesienie zaburzeń z jednego rynku w jednym kraju na pozostałe rynki świata, przyczyniając się do zaburzeń funkcjonowania wszystkich gospodarek narodowych. Problemem ważnym i niezbędnym dla dobrego funkcjonowania gospodarki światowej jest określenie procesów wczesnego przewidywania sytuacji kryzysowych gospodarki globalnej. Autorzy przedstawiają wstępne badanie empiryczne w zakresie analizy stanu gospodarki i stanu sektora bankowego oparte na ostatnich doświadczeniach polskiej gospodarki.
Indeks RESPECTIndex jako inicjatywa Giełdy Papierów Wartościowych w procesie tworzenia zasad CSR na polskim rynku kapitałowym
Authors: Wiśniewski Tomasz
Published: September 2024

Rozpoczęcie przez Giełdę Papierów Wartościowych w Warszawie pierwszego na polskim rynku kapitałowym projektu klasyfikacji spółek pod względem stosowania dobrych praktyk wraz z uwzględnieniem w swojej działalności biznesu odpowiedzialnego społecznie prowadzi do pytania czy projekt spełnia kładzione w nim założenia? Przeprowadzona w tym celu analiza taksonomiczna z wykorzystaniem miary TMAI wybranych wskaźników głównych indeksów giełdowych potwierdza, że spółki zakwalifikowane do portfela indeksu RESPECTIndex są bardziej atrakcyjne pod względem inwestycyjnym niż spółki z innych indeksów giełdowych.
Polski rynek otwartych funduszy inwestycyjnych na tle rynku europejskiego
Authors: Karpio Andrzej , Żebrowska-Suchodolska Dorota
Published: September 2024

Otwarte fundusze inwestycyjne (FIO) mają istotny wpływ na poziom rozwoju rynku kapitałowego. Dlatego autorzy podjęli próbę porównania rynku FIO w Polsce z rynkami w innych krajach europejskich, ze szczególnym uwzględnieniem krajów dawnego bloku wschodniego. Analizie poddano fundusze z różnych klas ryzyka, porównano zarówno zmiany w ilości funduszy, jak i wielkości aktywów. Wyniki wskazują na niewielki udział funduszy polskich w rynku europejskim, równocześnie wyróżniają się one w porównaniu z funduszami dawnych krajów socjalistycznych.
IN SILICO STUDY OF HYDROGEN PEROXIDE (H2O2) BINDING EFFECT TO EXTRACELLULAR SIGNAL-REGULATED KINASES (ERK)
Authors: Layla Athiyah , Widyarti Sri , Sumitro Sutiman Bambang
Published: September 2024

H2O2 can provide a physiological response by activating Mitogen activated protein kinase (MAPK) signaling components, it can phosphorylate and activate several regulatory proteins, which are closely related to gene expression, and growth promotion. H2O2 has neuroprotective abilities and potential to be a complementary therapy. It can be implemented in Parkinson Disease (PD) therapy, by activating Extracellular signal-regulated kinases (ERK/1/2/5) play central role in the control of endothel cell proliferation and activate apoptosis signal-regulating kinase 1 (ASK1), key modulators of the apoptosis cell or death balance. The main pathology of PD is amyloid fibrils composed of αSyn (α-Synuclein), can cause disruption of the blood-brain barrier (BBB.) Aggregate of αSyn caused mitochondrial dysfunction, dysregulation and apoptosis in barrier-type brain endothelial cells (BECs), it leads BBB leakage, increase BBB permeability and disrupt L-DOPA transport. Therefore, treatments that prevent vascular degeneration may be new targets for the of PD. This research used in silico method. The 3D structures of ligand and protein target was retrieved from PubChem and protein data bank (PDB). Ligand was converted using the Open Babel and molecular docking program used AutoDock Vina, as a plug-in in PyRx. Results were analysed using PyMOL and Discovery Studio. Molecular dynamics simulation used YASARA. From this study, H2O2 lowering RMSD and RMSF value of ERK 1/2/5 and ASK1. It is known that H2O2 can stabilize ERK 1/2/5 and ASK1.
Performance of Physicochemical Processes for the Removal of Cu2+ from Water: A Review
Authors: Zaghloul Ahmed , A Sabour
Published: September 2024

Today, in many regions of the world, fresh water resources for the production of drinking water are non-existent or insufficient in relation to population growth or industrial production, making it necessary to resort to water treatment processes. Elimination likely to rid this water of toxic elements before any discharge. Several purification techniques based on physicochemical and biological processes are used, including ion exchange, coagulation-flocculation, membrane separation and adsorption methods. The main objective of this work is to compare the performances of these techniques for the retention of Cu2+ ions. The results obtained indicate that the selected processes have great potential for the elimination of Cu2+ ions in aqueous solution and in particular the process of adsorption.
Advanced Nano Research on Titanium Dioxide Nanoparticles: Prospects, General and Green Synthesis with Applications in Nanotechnology and Nanomedicine
Authors: Selvin Rosilda , S Raj Shrisha , Naseem Saba , D Bhuvana , Shetty Ruchira R , Dave Priyanka
Published: September 2024

Large volumes of titanium dioxide (TiO2 ) nanoparticles (NPs) are produced globally for a variety of uses. The physicochemical characteristics of TiO2 nanoparticles differ from those of their fine particle (FP) analogues, potentially modifying their bioactivity. The majority of the research included here has addressed the respiratory system and demonstrated the significance of inhalation as the main method of exposure to TiO2 NP in the workplace. TiO2 NPs have the potential to move from the gastrointestinal tract (GIT) and lung to systemic organs, albeit this appears to happen at a slow rate. Additionally, research has been conducted on other human exposure pathways. TiO2 nanoparticulate carriers can be injected intravenously to enter the human body and be used in nanomedicine. Intravenous exposure to TiO2 NPs can result in pathological lesions in the brain, kidneys, liver, and spleen. Additionally, as we have demonstrated here, the majority of these effects might result from the use of extremely high concentrations of TiO2 NPs. Despite the rising manufacturing and usage of TiO2 NPs, there is also a dearth of epidemiological data on this topic. Lung tumors have been documented in long-term rat inhalation trials, however. This study outlines the present state of knowledge about the general and green synthesis methods of TiO2 nanoparticles with applications in medicine.
Recent Breakthroughs of Nanomedicine in Medical Fields
Authors: Reddy A Vijaya Bhaskar
Published: September 2024

Nanomedicine refers to the application of nanoparticles for disease diagnosis and treatment. Recent progresses in nanomedicine have demonstrated significant breakthroughs in enhancing the efficiency and safety of medical treatments. The key advances in nanomedicine for targeted drug delivery systems, to treat the spinal cord diseases, to enhance immune modulation and regenerative medicine have shown promising in recent years. Despite the advancements of nanomedicine, a few challenges such as biocompatibility, toxicity, and regulatory hurdles remain.
Exploring public views on the use of synthetic datasets for research - results from the DELIMIT study
Authors: Lugg-Widger Fiona , Nollett Claire , Brookes-Howell Lucy , Robling Mike , Trubey Rob
Published: September 2024

Background Synthetic data refers to datasets derived from ‘real’ administrative data records but sufficiently abstracted to minimise disclosure risk. They can be an efficient way for researchers to learn about the properties of datasets and inform data requests, prior to data applications.
However, little is understood about how the UK public feel about the creation and use of such datasets for research purposes.
Methods We worked with a community engagement agency (Egality Health) to recruit a diverse UK public panel, to discuss issues relating to the use of synthetic data in research.
Across four workshops, participants listened to presentations from topic experts, and deliberated on perceived benefits and risks of synthetic data, ethical issues and reflections on how to communicate clearly about synthetic data. Members agreed a set of recommendations for researchers, data custodians and policy makers.
Results We will summarise key themes and recommendations from the workshops, explaining how these might help inform future policy.
We will reflect on how these results fit with parallel work that has explored the views of researchers and data custodians on the use of synthetic data for research, and discuss potential international implications of our findings.
Conclusions and Implications As with any research that seeks to draw on the public’s data, it is vital that researchers and policy-makers engage with and involve the public in any decision making around synthetic data.
In presenting findings from this project, we seek to advocate for a public voice in this topic and to ensure that future policy - both in the UK and internationally - is aligned with public attitudes.
Hazard Analysis and Fire Risk Assessment in a Chemical Lab Based on the Example of Hydrogen Peroxide Production Unit
Authors:   Mendeleev University of Chemical Technology, Stetsenko I.A. , Kolesnikov A.V. ,   Mendeleev University of Chemical Technology, Akinin N.I. ,   Mendeleev University of Chemical Technology
Published: September 2024

The problem of fire risk assessment for chemical labs and hazard analysis in them has been considered. According to the authors, chemical labs are objects of increased fire hazard as large volumes of flammable and combustible substances are stored and handled in the labs. Emergencies that occurred in labs on the territory of the Russian Federation described by the authors confirm the necessity of timely fire risk assessment and management in order to ensure the safety of laboratory technicians and prevent negative consequences for the environment. The chemical lab of the non-organic substances and electrochemical processes department of the Tushino Complex of the Mendeleyev University of Chemical Technology has been selected for the examination. A unit for hydrogen peroxide production by the electrochemical method was installed in the lab; the size of the unit is planned to be increased to the scale of an industrial enterprise shortly. A five-stage method described in the Federal Law of 22.07.2008 № 123-FZ has been used as an approach to fire risk assessment. For hazard analysis, the HAZID method has been chosen. Prior to the HAZID session, a hazard analysis for the object of examination. The HAZID session has been conducted based on the example of a hydrogen peroxide production unit by electrochemical method. As a result, a list of identified hazards has been compiled, and recommendations to prevent or minimize the consequences have been developed. The hazards identified are used to assess potential threats via failure trees. The «Failure Tree» module is implemented in the RizEks-2 software product developed by the scientific risk study center RIZIKON. The software product Fenix+ is proposed to be used for individual fire risk assessment. Therefore, it has been concluded that this approach to fire risk assessment is applicable not only in the labs of the Mendeleyev University of Chemical Technologies but also in other technical schools, considering their specific features.