bluuebunny/crossref_metadata_2025 huggingface dataset:
Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth
Authors: Khan Husain Yar , Mpilla Gabriel B. , Sexton Rachel , Viswanadha Srikant , Penmetsa Kumar V. , Aboukameel Amro , Diab Maria , Kamgar Mandana , Al-Hallak Mohammed Najeeb , Szlaczky Mark , Tesfaye Anteneh , Kim Steve , Philip Philip A. , Mohammad Ramzi M. , Azmi Asfar S.
Published: March 2020

Pancreatic ductal adenocarcinoma (PDAC) remains an unmet clinical problem in urgent need of newer molecularly driven treatment modalities. Calcium signals, particularly those associated with calcium release-activated calcium (CRAC) channels, are known to influence the development, growth, and metastasis of many cancers. This is the first study investigating the impact of CRAC channel inhibition on PDAC cell lines and patient-derived tumor models. PDAC cell lines were exposed to a novel CRAC channel inhibitor, RP4010, in the presence or absence of standard of care drugs such as gemcitabine and nab-paclitaxel. The in vivo efficacy of RP4010 was evaluated in a hyaluronan-positive PDAC patient-derived xenograft (PDx) in the presence or absence of chemotherapeutic agents. Treatment of PDAC cell lines with single-agent RP4010 decreased cell growth, while the combination with gemcitabine/nab-paclitaxel exhibited synergy at certain dose combinations. Molecular analysis showed that RP4010 modulated the levels of markers associated with CRAC channel signaling pathways. Further, the combination treatment was observed to accentuate the effect of RP4010 on molecular markers of CRAC signaling. Anti-tumor activity of RP4010 was enhanced in the presence of gemcitabine/nab-paclitaxel in a PDAC PDx model. Our study indicates that targeting CRAC channel could be a viable therapeutic option in PDAC that warrants further clinical evaluation.
Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors
Authors: Tran Huy Minh , Wu Kuo-Sheng , Sung Shian-Ying , Changou Chun Austin , Hsieh Tsung-Han , Liu Yun-Ru , Liu Yen-Lin , Tsai Min-Lan , Lee Hsin-Lun , Hsieh Kevin Li-Chun , Huang Wen-Chang , Liang Muh-Lii , Chen Hsin-Hung , Lee Yi-Yen , Lin Shih-Chieh , Ho Donald Ming-Tak , Chang Feng-Chi , Chao Meng-En , Chen Wan , Chu Shing-Shung , Yu Alice L. , Yen Yun , Chang Che-Chang , Wong Tai-Tong
Published: March 2020

Atypical teratoid rhabdoid tumors (ATRTs) are among the most malignant brain tumors in early childhood and remain incurable. Myc-ATRT is driven by the Myc oncogene, which directly controls the intracellular protein synthesis rate. Proteasome inhibitor bortezomib (BTZ) was approved by the Food and Drug Administration as a primary treatment for multiple myeloma. This study aimed to determine whether the upregulation of protein synthesis and proteasome degradation in Myc-ATRTs increases tumor cell sensitivity to BTZ. We performed differential gene expression and gene set enrichment analysis on matched primary and recurrent patient-derived xenograft (PDX) samples from an infant with ATRT. Concomitant upregulation of the Myc pathway, protein synthesis and proteasome degradation were identified in recurrent ATRTs. Additionally, we found the proteasome-encoding genes were highly expressed in ATRTs compared with in normal brain tissues, correlated with the malignancy of tumor cells and were essential for tumor cell survival. BTZ inhibited proliferation and induced apoptosis through the accumulation of p53 in three human Myc-ATRT cell lines (PDX-derived tumor cell line Re1-P6, BT-12 and CHLA-266). Furthermore, BTZ inhibited tumor growth and prolonged survival in Myc-ATRT orthotopic xenograft mice. Our findings suggest that BTZ may be a promising targeted therapy for Myc-ATRTs.
CRIPTO and miR-371a-3p Are Serum Biomarkers of Testicular Germ Cell Tumors and Are Detected in Seminal Plasma from Azoospermic Males
Authors: Spiller Cassy M. , Lobo João , Boellaard Willem P. A. , Gillis Ad J. M. , Bowles Josephine , Looijenga Leendert H. J.
Published: March 2020

miR-371a-3p is currently the most informative reported biomarker for germ cell tumors (GCTs). Another developmental-related biomarker, CRIPTO, is involved in the regulation of pluripotency and germ cell fate commitment. We aimed to assess the value of CRIPTO as a diagnostic and prognostic biomarker of testicular GCTs (TGCTs) and also to assess its presence in seminal plasma samples, compared with miR-371a-3p. In total, 217 and 94 serum/seminal plasma samples were analyzed. CRIPTO was quantified using ELISA and miR-371a-3p using bead-based isolation followed by RT-qPCR. Methylation profiling (EPIC array) for the CRIPTO promoter region was undertaken in 35 TGCT tissues plus four (T)GCT cell lines. Significantly higher CRIPTO concentration was found in sera of non-seminomas compared to controls (p = 0.0297), and in stage II/III disease compared to stage I (p = 0.0052, p = 0.0097). CRIPTO concentration was significantly positively correlated with miR-371a-3p levels in serum (r = 0.16) and seminal plasma (r = 0.40). CRIPTO/miR-371a-3p levels were significantly higher in seminal plasma controls when compared to serum controls (p = 0.0001, p < 0.0001). CRIPTO/miR-371a-3p were detected both in normospermic and azoospermic males, and levels were higher in TGCTs compared to GCNIS-only. We have provided the largest dataset of evaluation of CRIPTO in serum and seminal plasma of GCTs, showing its potential value as a biomarker of the disease.
The Diversity Distribution Pattern of Ruderal Community under the Rapid Urbanization in Hangzhou, East China
Authors: Zhang Mingli , Song Kun , Da Liangjun
Published: March 2020

The process of rapid urbanization has affected the composition and diversity of urban vegetation species. The process of urbanization from 2000 was analyzed in the area of "one major city with three vice cities and six groups", according to the urban master planning of Hangzhou from 2001 to 2020. The results show that dramatic changes have occurred for land use types during the ten years from 2000 to 2010 in Hangzhou, of which urban land has become the main type of land use and the area of arable land has presented serious loss. This study found that the Gramineae and Compositae species were the main groups of ruderals in 1665 quadrats, which reflected the characteristics of a few large families. The number of Monotypic and Oligotypic family/genera accounted for 67.3% of the total number of families and 97.5% of the total number of genera. The ruderals were dominated by annual life forms with strong adaptability and high plasticity. The ruderal communities in the study areas were divided into 125 community types based on clustering analysis of the dominance of ruderal species. The proportion of summer annual ruderals in the dominant species of ruderal communities gradually decreased along the group-vice city-major city gradient. The percentage of winter annual ruderals was the highest and the percentage of perennials was the lowest in the groups. The number of ruderal community types showed a nonlinear decreasing trend along the urbanization gradient of the group-vice city-major city. The number of ruderal communities in the vice cities and the groups was similar, which was higher than that in the major city. Only species that are highly tolerant to urban habitats can be distributed under frequent and high-intensity human disturbances in the major city. Therefore, the number of ruderal communities in the major city was minimal and it had low diversity.
Penetration Resistance of Laacher See-tephra Andosols—Evaluating Rooting Conditions of Undisturbed and Excavated Forest Soils in SW-Germany
Authors: Zemke Julian J. , Bange Ulli , Dellen John , Groh Ines , Henn Roxane C. A. , Pöhler Joshua , Stegmann Stephan
Published: March 2020

This study discusses penetration resistance (PR) of forested Pumice-Andosol sites. PR, a key soil property influencing root growth and elongation, exerts a substantial influence on ecological site quality and tree growth. Andosols were expected to show low PR because of their unique characteristics (low bulk density, loose soil matrix). Five sites, two undisturbed and three backfilled, were sampled. The latter result from pumice excavation and were examined to quantify potential PR alterations in the aftermath of backfilling and pumice removal. Penetrologger sampling on undisturbed sites showed mean PR not exceeding 3 MPa, a literature-based, critical threshold restricting root growth, in the upper 0.80 m, indicating conditions fostering tree rooting. Backfilled sites mostly exhibited increased (> 3 MPa) PR, leading to rooting restrictions even beginning at −0.21 m. Deviations from undisturbed soils range from −15.6 to +109.3% depending on depth and age of the backfilled site. Furthermore, GIS-based data interpolation helped to identify spatial PR patterns and allowed a direct comparison before/after backfilling at one site. Statistical analysis revealed significantly altered PR after backfilling, while a concluding ANOVA provided at least significant governing factors (depth, area, clay + silt content, soil organic matter), albeit with only small effect sizes.
Increased Drought Sensitivity Results in a Declining Tree Growth of Pinus latteri in Northeastern Thailand
Authors: Rakthai Sakkarin , Fu Pei-Li , Fan Ze-Xin , Gaire Narayan , Pumijumnong Nathsuda , Eiadthong Wichan , Tangmitcharoen Suwan
Published: March 2020

Climate change may lead to alterations in tree growth and carbon cycling. Interpreting the response of forest growth to climate change requires an understanding of the temporal and spatial patterns of seasonal climatic influences on the growth of tree species. However, the effects of climate change on pine forest dynamics in tropical region of Thailand remain poorly understood. This study develops three new tree ring-width chronologies of Pinus latteri (Tenasserim pine) in northern and northeastern Thailand and analyzes their climate-growth relationships and temporal stability. Ring-width chronologies of P. latteri at three sites showed significantly positive correlations with precipitation, relative humidity and self-calibrated Palmer Drought Severity Index (scPDSI) during the dry season (previous November to current April) and early rainy season (May–June). Conversely, significantly negative correlations were found between ring-width site chronologies and air temperatures (mean, maximum and minimum) from April to August. Therefore, our results revealed that radial growth of Tenasserim pines from northern and northeastern Thailand was mainly limited by moisture availability during the dry-to-wet transition season from April to June. Moving correlations revealed that Tenasserim pines in the lowland area of northeastern Thailand became more sensitive to moisture availability in recent 30 years (1985–2017) as compared with early period (1951–1984). Accompanying the shifted growth sensitivity to climate change, growth synchrony among trees was increasing and tree growth rates of Tenasserim pines have been declining during recent decades at two more moisture-limited sites in northeastern Thailand. Recent rapid warming and increasing drought during the transition season (April–June) together intensify climatic constrains on tree growth of Tenasserim pines in the lowland area of northeastern Thailand. Considering continued regional climate change, pine forests in tropical lowland areas may encounter intensified drought stresses, and thus, become more vulnerable to future climate change. Our results serve as an early indicator of potential effects of climate change on tropical pine species and raise concerns about sustainable managements of pine forests under a changing climate.
Characterizing over Four Decades of Forest Disturbance in Minnesota, USA
Authors: Vogeler Jody , Slesak Robert , Fekety Patrick , Falkowski Michael
Published: March 2020

Spatial information about disturbance driven patterns of forest structure and ages across landscapes provide a valuable resource for all land management efforts including cross-ownership collaborative forest treatments and restoration. While disturbance events in general are known to impact stand characteristics, the agent of change may also influence recovery and the supply of ecosystem services. Our study utilizes the full extent of the Landsat archive to identify the timing, extent, magnitude, and agent, of the most recent fast disturbance event for all forested lands within Minnesota, USA. To account for the differences in the Landsat sensors through time, specifically the coarser spatial, spectral, and radiometric resolutions of the early MSS sensors, we employed a two-step approach, first harmonizing spectral indices across the Landsat sensors, then applying a segmentation algorithm to fit temporal trends to the time series to identify abrupt forest disturbance events. We further incorporated spectral, topographic, and land protection information in our classification of the agent of change for all disturbance patches. After allowing two years for the time series to stabilize, we were able to identify the most recent fast disturbance events across Minnesota from 1974–2018 with a change versus no-change validation accuracy of 97.2% ± 1.9%, and higher omission (14.9% ± 9.3%) than commission errors (1.6% ± 1.9%) for the identification of change patches. Our classification of the agent of change exhibited an overall accuracy of 96.5% ± 1.9% with classes including non-disturbed forest, land conversion, fire, flooding, harvest, wind/weather, and other rare natural events. Individual class errors varied, but all class user and producer accuracies were above 78%. The unmatched nature of the Landsat archive for providing comparable forest attribute and change information across more than four decades highlights the value of the totality of the Landsat program to the larger geospatial, ecological research, and forest management communities.
The Nickel: A History of African-Descended People in Houston’s Fifth Ward
Authors: Frazier Denise
Published: March 2020

This paper will chronicle the unique stories that have come to exemplify the larger experience of Fifth Ward as a historically African American district in a rapidly changing city, Houston. Fifth Ward is a district submerged in the Southern memory of a sprawling port city. Its 19th century inception comprised of residents from Eastern Europe, Russia, and other religious groups who were fleeing persecution. Another way to describe Fifth Ward is much closer to the Fifth Ward that I knew as a child—an African American Fifth Ward and, more personally, my grandparents’ neighborhood. The growing prosperity of an early 20th century oil-booming Houston had soon turned the neighborhood into an economic haven, attracting African Americans from rural Louisiana and east Texas. Within the past two decades, Latino communities have populated the area, transforming the previously majority African American ward. Through a qualitative familial research review of historic documents, this paper contains a cultural and economic analysis that will illustrate the unique legacies and challenges of its past and present residents. I will center my personal genealogical roots to connect with larger patterns of change over time for African Americans in this distinct cultural ward.
The Role of Corneal Biomechanics for the Evaluation of Ectasia Patients
Authors: Salomão Marcella Q. , Hofling-Lima Ana Luisa , Gomes Esporcatte Louise Pellegrino , Lopes Bernardo , Vinciguerra Riccardo , Vinciguerra Paolo , Bühren Jens , Sena Nelson , Luz Hilgert Guilherme Simões , Ambrósio Renato
Published: March 2020

Purpose: To review the role of corneal biomechanics for the clinical evaluation of patients with ectatic corneal diseases. Methods: A total of 1295 eyes were included for analysis in this study. The normal healthy group (group N) included one eye randomly selected from 736 patients with healthy corneas, the keratoconus group (group KC) included one eye randomly selected from 321 patients with keratoconus. The 113 nonoperated ectatic eyes from 125 patients with very asymmetric ectasia (group VAE-E), whose fellow eyes presented relatively normal topography (group VAE-NT), were also included. The parameters from corneal tomography and biomechanics were obtained using the Pentacam HR and Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany). The accuracies of the tested variables for distinguishing all cases (KC, VAE-E, and VAE-NT), for detecting clinical ectasia (KC + VAE-E) and for identifying abnormalities among the VAE-NT, were investigated. A comparison was performed considering the areas under the receiver operating characteristic curve (AUC; DeLong’s method). Results: Considering all cases (KC, VAE-E, and VAE-NT), the AUC of the tomographic-biomechanical parameter (TBI) was 0.992, which was statistically higher than all individual parameters (DeLong’s; p < 0.05): PRFI- Pentacam Random Forest Index (0.982), BAD-D- Belin -Ambrosio D value (0.959), CBI -corneal biomechanical index (0.91), and IS Abs- Inferior-superior value (0.91). The AUC of the TBI for detecting clinical ectasia (KC + VAE-E) was 0.999, and this was again statistically higher than all parameters (DeLong’s; p < 0.05): PRFI (0.996), BAD-D (0.995), CBI (0.949), and IS Abs (0.977). Considering the VAE-NT group, the AUC of the TBI was 0.966, which was also statistically higher than all parameters (DeLong’s; p < 0.05): PRFI (0.934), BAD- D (0.834), CBI (0.774), and IS Abs (0.677). Conclusions: Corneal biomechanical data enhances the evaluation of patients with corneal ectasia and meaningfully adds to the multimodal diagnostic armamentarium. The integration of biomechanical data and corneal tomography with artificial intelligence data augments the sensitivity and specificity for screening and enhancing early diagnosis. Besides, corneal biomechanics may be relevant for determining the prognosis and staging the disease.
A System Dynamics Model for Ecological Environmental Management in Coal Mining Areas in China
Authors: Shi Fulei , Cao Haiqing , Wang Chuansheng , Yao Cuiyou
Published: March 2020

In recent years, mounting attention has been paid to ecological environmental management in coal mining areas in China. This paper conducts a system dynamics (SD) model for ecological environmental management in coal mining areas. Firstly, the whole causal loop diagram of the system is built to illustrate the general system. Secondly, five subsystems are presented according to the causal loop diagram. Then, given the stable investment for ecological environmental management in coal mining areas, our objective is to find a better allocation that can get the best ecological environmental quality in coal mining areas. Notably, we present six allocations of the investment for ecological environmental management in coal mining areas. The results show that, in allocation 4, we can get the best ecological environmental quality in coal mining areas. That is, the best improvement of mining environment can be achieved by distributing the treatment cost highly on the proportion of investment in green vegetation.
Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study
Authors: Karbownik-Lewińska Małgorzata , Stępniak Jan , Żurawska Anna , Lewiński Andrzej
Published: March 2020

High-normal TSH can be associated with metabolic abnormalities and infertility. Aims of this study are to analyze retrospectively if routinely measured blood laboratory and anthropometric parameters differ between women of reproductive age with TSH < 2.5 mIU/L and with TSH ≥ 2.5 mIU/L. Retrospective analysis was performed in 466 female inpatients, aged 13–51, hospitalized in an endocrine department. The group of 280 patients with normal thyroid tests (TSH 0.27-4.2 mIU/L; normal FT3 and FT4) was selected and it was divided into two subgroups, i.e., with TSH < 2.5 mIU/L and TSH ≥ 2.5 mIU/L (n = 66; 23.6%). After excluding patients on L-thyroxine treatment (n = 240), those with TSH ≥ 2.5 mIU/L constituted 22.92% (n = 55). In the group of 280 patients with normal thyroid tests, an abnormally high concentration of triglycerides and an abnormally low HDLC/cholesterol ratio occurred more frequently in women with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (17% vs. 7%, p = 0.017; 14% vs. 5%, p = 0.015, respectively). Increased concentration of thyroid antibodies, i.e., TPOAb, occurred more frequently in patients with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (27% vs. 9%, p = 0.001). The same differences were found in the group of 240 patients after excluding those on L-thyroxine treatment. Blood lymphocyte concentration was the only independent linear parameter associated with TSH ≥ 2.5 mIU/L (OR = 1.551, p = 0.024) but only in the group of 280 patients with normal thyroid tests. TSH concentration correlated positively with blood lymphocyte (r = 0.129, p = 0.031) and TPOAb (r = 0.177, p = 0.005) concentrations but only in the group of 280 patients with normal thyroid tests. Less favorable lipid profiles and a higher prevalence of thyroid antibodies in women of reproductive age with high-normal TSH suggests that L-thyroxine treatment should be considered in such patients. The significance of a positive association between high-normal TSH and blood lymphocytes requires further evaluation.
Modelling the 200 m Front-Crawl Performance Predictors at the Winter Season Peak
Authors: Costa Mário J. , Santos Catarina C. , Marinho Daniel A. , Silva António J. , Barbosa Tiago M.
Published: March 2020

This study aimed to identify potential predictors of 200 m front crawl performance at the winter season peak based on the anthropometric, physiological and biomechanical domains. Twelve expert male swimmers completed an incremental 7 × 200 m step test immediately after their most important winter competitions. Measurements were made of: (i) height, body mass and arm span as anthropometrical parameters; (ii) velocity at a 4 mmol·L−1 lactate concentration (V4), maximal oxygen uptake (VO2máx) and energy cost (C), as physiological parameters; (iii) stroke frequency (SF), stroke length (SL), stroke index (SI) and propelling efficiency (ηp) as biomechanical indicators; and (iv) 200 m front crawl race time in official long course competitions. Spearman correlation coefficients identified V4 as the single factor having significant relationship with performance. Simple regression analysis determined V4, SI and arm span as the most relevant variables of each group. Multiple linear regression models showed that physiological factors explained better (59%) the variation in performance at this stage of the season, followed by the biomechanical (14%) ones. Therefore, V4 can be one important aspect for training control and diagnosis for those who want to achieve success in the 200 m front crawl at the winter season peak.
Sex Differences in Comorbidity, Therapy, and Health Services’ Use of Heart Failure in Spain: Evidence from Real-World Data
Authors: Gracia Gutiérrez Anyuli , Poblador-Plou Beatriz , Prados-Torres Alexandra , Ruiz Laiglesia Fernando J , Gimeno-Miguel Antonio
Published: March 2020

Heart failure (HF) is becoming increasingly prevalent and affects both men and women. However, women have traditionally been underrepresented in HF clinical trials. In this study, we aimed to analyze sex differences in the comorbidity, therapy, and health services’ use of HF patients. We conducted a cross-sectional study in Aragón (Spain) and described the characteristics of 17,516 patients with HF. Women were more frequent (57.4 vs. 42.6%, p < 0.001) and older (83 vs. 80 years, p < 0.001) than men, and presented a 33% lower risk of 1-year mortality (p < 0.001). Both sexes showed similar disease burdens, and 80% suffered six or more diseases. Some comorbidities were clearly sex-specific, such as arthritis, depression, and hypothyroidism in women, and arrhythmias, ischemic heart disease, and COPD in men. Men were more frequently anti-aggregated and anti-coagulated and received more angiotensin-converting-enzyme (ACE) inhibitors and beta-blockers, whereas women had more angiotensin II antagonists, antiinflammatories, antidepressants, and thyroid hormones dispensed. Men were admitted to specialists (79.0 vs. 70.6%, p < 0.001), hospital (47.0 vs. 38.1%, p < 0.001), and emergency services (57.6 vs. 52.7%, p < 0.001) more frequently than women. Our results highlight the need to conduct future studies to confirm the existence of these differences and of developing separate HF management guidelines for men and women that take into account their sex-specific comorbidity.
A Stochastic Multi-Attribute Method for Measuring Sustainability Performance of a Supplier Based on a Triple Bottom Line Approach in a Dual Hesitant Fuzzy Linguistic Environment
Authors: Qu Guohua , Xue Rudan , Li Tianjiao , Qu Weihua , Xu Zeshui
Published: March 2020

China is a developing country and with the speeding up of its industrialization, the environmental problems are becoming more serious, environmental pollution is a major environmental health problem in China. In order to have a more effective management and control of the significant growth issues of environment pollution, green supply chain incentives have started, which is kind of market incentive aiming to moderate the adverse effects of environmental pollution. Proper green chain supply selection and evaluation of companies is becoming very essential in sustainable green supply chain management. Generally speaking, decision-makers (DMs) prefer to provide a set of feasible and quantitative information for making performance evaluation, which motivates us to propose a framework using dual hesitant fuzzy linguistic term set (DHFLTS) and hesitant fuzzy linguistic term set (HFLTS) to select green suppliers. In this paper, group satisfaction and the regret theory are adopted for elicitation of preference information. The DHFLTS and HFLTS provide qualitative preferences of the DMs as well as reflect their hesitancy, inconsistency, and vagueness. Further, two new group satisfaction degrees are defined called the group satisfaction of hesitant fuzzy linguistic term set and dual hesitant fuzzy linguistic term set. Some properties of group satisfaction with DHFLST and HFL are also discussed. Unknown attribute weights are obtained to construct a novel Lagrange function optimization model to maximize the group satisfaction degree, which is an extension of general group satisfaction degree. A novel methodological approach based on two group satisfaction degrees framework and regret theory is developed to rank and select green chain suppliers focusing on specific selection objectives. The proposed model and method of this paper allow the DM to execute different fuzzy scenarios by changing importance weights attached to the triple-bottom-line areas. In the final part, the advantage of the proposed group satisfaction degree under DHFL and HFL background over the existing group satisfaction degree using examples have been presented with different computational combinations.
Physical Disorders are Associated with Health Risk Behaviors in Chinese Adolescents: A Latent Class Analysis
Authors: Song Bingdong , Hu Weirong , Hu Wanxia , Yang Rong , Li Danlin , Guo Chunyu , Xia Zhengmei , Hu Jie , Tao Fangbiao , Fang Jun , Zhang Shichen
Published: March 2020

It is known that health risk behaviors (HRBs) can lead to a variety of physical and mental health problems among adolescents, but few studies have paid attention to the relationship between latent classes of HRBs and adolescent diseases. The purpose of this study was to use latent class analysis (LCA) to clarify the potential subgroups of HRBs (smoking, drinking, screen time, non-suicidal self-injuries, suicidal behaviors, and unintentional injuries) and examine the association between the subgroups of HRBs and physical disorders (diarrhea, fever, cough, and vomiting) with multiple logistic regression analysis, in Chinese adolescents. Self-reported HRBs and physical disorders were used to evaluate 22,628 middle school students in six cities of China, from November 2015 to January 2016, based on a multistage stratified cluster sampling approach. The prevalence of diarrhea, fever, cough, and vomiting was 23.5%, 15.9%, 50.6%, and 10.7%, respectively. We identified four latent classes of HRBs by LCA, including low-risk class, moderate-risk class 1 (smoking, drinking, and screen time), moderate-risk class 2 (non-suicidal self-injuries and suicidal behaviors, unintentional injuries), and high-risk class (smoking, drinking, screen time, non-suicidal self-injuries, suicidal behaviors, and unintentional injuries), which were 64.0%, 4.5%, 28.8% and 2.7% of participants, respectively. Compared to the low-risk class, all other classes showed higher risk for these physical disorders (P < 0.01 for each). In particular, the high-risk class had the highest risk (diarrhea (odds ratio (OR) = 2.628, 95% confidence interval (CI) 2.219 to 3.113), fever (OR = 3.103, 95% CI 2.591 to 3.717), cough (OR = 2.142, 95% CI 1.805 to 2.541), and vomiting (OR = 3.738, 95% CI 3.081 to 4.536). In conclusion, these results indicated that heterogeneity exists in HRBs, and subgroups of HRBs were correlated to the occurrence of common physical disorders in Chinese adolescents. Therefore, multiple HRBs rather than single factors should be considered for the prevention of common physical disorders in schools.
Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis
Authors: Goetschalckx Elise , Mekahli Djalila , Levtchenko Elena , Allegaert Karel
Published: March 2020

Various cohort studies document a lower glomerular filtration rate (GFR) in former extremely low birth weight (ELBW, <1000 g) neonates throughout childhood when compared to term controls. The current aim is to pool these studies to describe the GFR pattern over the pediatric age range. To do so, we conducted a systematic review on studies reporting on GFR measurements in former ELBW cases while GFR data of healthy age-matched controls included in these studies were co-collected. Based on 248 hits, 6 case-control and 3 cohort studies were identified, with 444 GFR measurements in 380 former ELBW cases (median age 5.3–20.7 years). The majority were small (17–78 cases) single center studies, with heterogeneity in GFR measurement (inulin, cystatin C or creatinine estimated GFR formulae) tools. Despite this, the median GFR (mL/min/1.73 m2) within case-control studies was consistently lower (−13%, range −8% to −25%) in cases, so that a relevant minority (15–30%) has a eGFR<90 mL/min/1.73 m2). Consequently, this pooled analysis describes a consistent pattern of reduced eGFR in former ELBW cases throughout childhood. Research should focus on perinatal risk factors for impaired GFR and long-term outcome, but is hampered by single center cohorts, study size and heterogeneity of GFR assessment tools.
Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis
Authors: Cațan Liliana , Cerbu Simona , Amaricai Elena , Suciu Oana , Horhat Delia Ioana , Popoiu Călin Marius , Adam Ovidiu , Boia Eugen
Published: March 2020

(1) Background: Adolescent idiopathic scoliosis (AIS) can be associated with vitamin D deficiency and osteopenia. Plantar pressure and stabilometry offer important information about posture. The objectives of our study were to compare static plantar pressure and stabilometric parameters, serum 25-OH-vitamin D3 and calcium levels, and bone mineral densitometry expressed as z-score in patients with moderate AIS and healthy subjects. (2) Methods: 32 female adolescents (idiopathic S shaped moderate scoliosis, main lumbar curve) and 32 gender and age-matched controls performed: static plantar pressure, stabilometry, serum 25-OH-vitamin D3 and calcium levels, and dual X-ray absorptiometry scans of the spine. (3) Results: In scoliosis patients, significant differences were recorded between right and left foot for total foot, first and fifth metatarsal, and heel loadings. Stabilometry showed a poorer postural control when compared to healthy subjects (p < 0.001). Patients had significantly lower vitamin D, calcium levels, and z-scores. Lumbar Cobb angle was significantly correlated with the z-score (r = −0.39, p = 0.02), with right foot fifth metatarsal load (r = −0.35, p = 0.04), center of pressure CoPx (r = −0.42, p = 0.01), CoP displacement (r = 0.35, p = 0.04) and 90% confidence ellipse area (r = −0.38, p = 0.03). (4) Conclusions: In our study including female adolescents with idiopathic S shaped moderate scoliosis, plantar pressure and stabilometric parameters were influenced by the main scoliotic curve.
Extended Classification Course Improves Road Intersection Detection from Low-Frequency GPS Trajectory Data
Authors: Chen Banqiao , Ding Chibiao , Ren Wenjuan , Xu Guangluan
Published: March 2020

The requirements of location-based services have generated an increasing need for up-to-date digital road maps. However, traditional methods are expensive and time-consuming, requiring many skilled operators. The feasibility of using massive GPS trajectory data provides a cheap and quick means for generating and updating road maps. The detection of road intersections, being the critical component of a road map, is a key problem in map generation. Unfortunately, low sampling rates and high disparities are ubiquitous among floating car data (FCD), making road intersection detection from such GPS trajectories very challenging. In this paper, we extend a point clustering-based road intersection detection framework to include a post-classification course, which utilizes the geometric features of road intersections. First, we propose a novel turn-point position compensation algorithm, in order to improve the concentration of selected turn-points under low sampling rates. The initial detection results given by the clustering algorithm are recall-focused. Then, we rule out false detections in an extended classification course based on an image thinning algorithm. The detection results of the proposed method are quantitatively evaluated by matching with intersections from OpenStreetMap using a variety of distance thresholds. Compared with other methods, our approach can achieve a much higher recall rate and better overall performance, thereby better supporting map generation and other similar applications.
Nest Site Selection during Colony Relocation in Yucatan Peninsula Populations of the Ponerine Ants Neoponera villosa (Hymenoptera: Formicidae)
Authors: Rocha Franklin H. , Lachaud Jean-Paul , Hénaut Yann , Pozo Carmen , Pérez-Lachaud Gabriela
Published: March 2020

In the Yucatan Peninsula, the ponerine ant Neoponera villosa nests almost exclusively in tank bromeliads, Aechmea bracteata. In this study, we aimed to determine the factors influencing nest site selection during nest relocation which is regularly promoted by hurricanes in this area. Using ants with and without previous experience of Ae. bracteata, we tested their preference for refuges consisting of Ae. bracteata leaves over two other bromeliads, Ae. bromeliifolia and Ananas comosus. We further evaluated bromeliad-associated traits that could influence nest site selection (form and size). Workers with and without previous contact with Ae. bracteata significantly preferred this species over others, suggesting the existence of an innate attraction to this bromeliad. However, preference was not influenced by previous contact with Ae. bracteata. Workers easily discriminated between shelters of Ae. bracteata and A. comosus, but not those of the closely related Ae. bromeliifolia. In marked contrast, ants discriminated between similar sized Ae. bracteata and Ae. bromeliifolia plants, suggesting that chemical cues and plant structure play an important role. Size was also significant as they selected the largest plant when provided two dissimilar Ae. bracteata plants. Nest site selection by N. villosa workers seems to depend on innate preferences but familiarization with plant stimuli is not excluded.
Synergistic Influences of Stearic Acid Coating and Recycled PET Microfibers on the Enhanced Properties of Composite Materials
Authors: Nguyen Dang Mao , Vu Thi Nhung , Nguyen Thi Mai Loan , Nguyen Trinh Duy , Thuc Chi Nhan Ha , Bui Quoc Bao , Colin Julien , Perré Patrick
Published: March 2020

This study aims to produce novel composite artificial marble materials by bulk molding compound processes, and improve their thermal and mechanical properties. We employed stearic acid as an efficient surface modifying agent for CaCO3 particles, and for the first time, a pretreated, recycled, polyethylene terephthalate (PET) fibers mat is used to reinforce the artificial marble materials. The innovative aspects of the study are the surface treatment of CaCO3 particles by stearic acid. Stearic acid forms a monolayer shell, coating the CaCO3 particles, which enhances the compatibility between the CaCO3 particles and the matrix of the composite. The morphology of the composites, observed by scanning electron microscopy, revealed that the CaCO3 phase was homogeneously dispersed in the epoxy matrix under the support of stearic acid. A single layer of a recycled PET fibers mat was pretreated and designed in the core of the composite. As expected, these results indicated that the fibers could enhance flexural properties, and impact strength along with thermal stability for the composites. This combination of a pretreated, recycled, PET fibers mat and epoxy/CaCO3-stearic acid could produce novel artificial marble materials for construction applications able to meet environmental requirements.
Electro-Oxidation–Plasma Treatment for Azo Dye Carmoisine (Acid Red 14) in an Aqueous Solution
Authors: Barrera Héctor , Cruz-Olivares Julián , Frontana-Uribe Bernardo A. , Gómez-Díaz Aarón , Reyes-Romero Pedro G. , Barrera-Diaz Carlos E.
Published: March 2020

Currently, azo dye Carmoisine is an additive that is widely used in the food processing industry sector. However, limited biodegradability in the environment has become a major concern regarding the removal of azo dye. In this study, the degradation of azo dye Carmoisine (acid red 14) in an aqueous solution was studied by using a sequenced process of electro-oxidation–plasma at atmospheric pressure (EO–PAP). Both the efficiency and effectiveness of the process were compared individually. To ascertain the behavior of azo dye Carmoisine over the degradation process, the variations in its physical characteristics were analyzed with a voltage–current relationship, optical emission spectra (OES) and temperature. On the other hand, chemical variables were analyzed by finding out pH, electrical conductivity, absorbance (UV/VIS Spectrophotometry), chemical oxygen demand (COD), cyclic voltammetry (CV), energy consumption and cost. The sequenced process (EO–PAP) increased degradation efficiency, reaching 100% for azo dye Carmoisine (acid red 14) in 60 min. It was observed that the introduction of small quantities of iron metal ions (Fe2+/Fe3+) as catalysts into the plasma process and the hydrogen peroxide formed in plasma electrical discharge led to the formation of larger amounts of hydroxyl radicals, thus promoting a better performance in the degradation of azo dye. This sequenced process increased the decolorization process.
Mechanical Properties, Microstructure, and Chloride Content of Alkali-Activated Fly Ash Paste Made with Sea Water
Authors: Siddique Salman , Jang Jeong Gook
Published: March 2020

The aim of the present study is to investigate the potential of sea water as a feasible alternative to produce alkali-activated fly ash material. The alkali-activated fly ash binder was fabricated by employing conventional pure water, tap water, and sea water based alkali activating solution. The characteristics of alkali-activated materials were examined by employing compressive strength, mercury intrusion porosimetry, XRD, FT-IR, and 29Si NMR along with ion chromatography for chloride immobilization. The results provided new insights demonstrating that sea water can be effectively used to produce alkali activated fly ash material. The presence of chloride in sea water contributed to increase compressive strength, refine microstructure, and mineralogical characteristics. Furthermore, a higher degree of polymerization on the sea water-based sample was observed by FT-IR and 29Si NMR analysis. However, the higher amount of free chloride ion even after immobilization in sea water-based alkali-activated material, should be considered before application in reinforced structural elements.
Resistance Characteristics of SMA Actuator Based on the Variable Speed Phase Transformation Constitutive Model
Authors: Lu Yifan , Zhang Rongru , Xu Ye , Wang Lei , Yue Honghao
Published: March 2020

The shape memory alloy (SMA)-based actuators have been increasingly used in different domains, such as automotive, aerospace, robotic and biomedical applications, for their unique properties. However, the precision control of such SMA-based actuators is still a problem. Most traditional control methods use the force/displacement signals of the actuator as feedback signals, which may increase the volume and weight of the entire system due to the additional force/displacement sensors. The resistance of the SMA, as an inherent property of the actuator, is a dependent variable which varies in accordance with its macroscopic strain or stress. It can be obtained by the voltage and the current imposed on the SMA with no additional measuring devices. Therefore, using the resistance of the SMA as feedback in the closed-loop control is quite promising for lightweight SMA-driven systems. This paper investigates the resistance characteristics of the SMA actuator in its actuation process. Three factors, i.e., the resistivity, the length, and the cross-sectional area, which affect the change of resistance were analyzed. The mechanical and electrical parameters of SMA were obtained using experiments. Numerical simulations were performed by using the resistance characteristic model. The simulation results reveal the change rules of the resistance corresponding to the strain of SMA and demonstrate the possibility of using the resistance for feedback control of SMA.
The Effect of a Corrosion Inhibitor on the Rehabilitation of Reinforced Concrete Containing Sea Sand and Seawater
Authors: Pan Chonggen , Li Xu , Mao Jianghong
Published: March 2020

Concrete made with sea sand and seawater is rich in chlorine ions which are the main factors that induce corrosion of the reinforcement. In this study, an innovative method to rehabilitate reinforcement is presented; the concentrations of chloride ions and the corrosion inhibitor in concrete were measured. Electrochemical chloride extraction (ECE) was applied as a control experiment via using saturated Ca(OH)2 solution as an external electrolyte. Bidirectional electromigration (BIEM)technology combined with the corrosion inhibitor could not only remove the chloride ions but also protect the steel bar in concrete, and animidazoline inhibitor mixed in concrete is more effective than thetriethylenetetramine inhibitor due to the specific molecular structure. It was found that the optimum ratio of N/Cl reached the maximum value 3.3, when the concentration of inhibitor was 1. Meanwhile, the experimental results also revealed that the corrosion inhibitor and chloride ion concentrations reached necessary levels on the surface of the steel, and the corrosion inhibitor migrated effectively. Overall, the contents of imidazoline and triethylenetetramine inhibitor in seawater concrete are0.75% and 1%, respectively. The results demonstrate that the addition of the corrosion inhibitor and the application of bidirectional electromigration would effectively improve the durability of reinforced concrete containing sea sand and seawater.
Analysis of One-Dimensional Ivshin–Pence Shape Memory Alloy Constitutive Model for Sensitivity and Uncertainty
Authors: Islam A B M Rezaul , Karadoğan Ernur
Published: March 2020

Shape memory alloys (SMAs) are classified as smart materials due to their capacity to display shape memory effect and pseudoelasticity with changing temperature and loading conditions. The thermomechanical behavior of SMAs has been simulated by several constitutive models that adopted microscopic thermodynamic or macroscopic phenomenological approaches. The Ivshin–Pence model is one of the most popular SMA macroscopic phenomenological constitutive models. The construction of the model requires involvement of parameters that possess inherent uncertainty. Under varying operating temperatures and loading conditions, the uncertainty in these parameters propagates and, therefore, affects the predictive power of the model. The propagation of uncertainty while using this model in real-life applications can result in performance discrepancies or failure at extreme conditions. In this study, we employed a probabilistic approach to perform the sensitivity and uncertainty analysis of the Ivshin–Pence model. Sobol and extended Fourier Amplitude Sensitivity Testing (eFAST) methods were used to perform the sensitivity analysis for simulated isothermal loading/unloading at various operating temperatures. It is evident that the model’s prediction of the SMA stress–strain curves varies due to the change in operating temperature and loading condition. The average and stress-dependent sensitivity indices present the most influential parameters at several temperatures.
Research on a Micro-Processing Technology for Fabricating Complex Structures in Single-Crystal Quartz
Authors: Han Chao , Li Cun , Zhao Yulong , Li Bo , Wei Xueyong
Published: March 2020

Single-crystal quartz material is widely applied in the manufacture of resonators and sensors, but it is difficult to process because of its high hardness. A novel way to fabricate single-crystal quartz structures is proposed in this paper; the method includes quartz-on-silicon (QoS) technology and inductively coupled plasma (ICP) etching, which makes it feasible to fabricate complex structures with crystal quartz. The QoS method encompasses the bonding of silicon and quartz, followed by the thinning and polishing of quartz, which can enable the fabrication of an ultra-thin quartz wafer on silicon. In this way, instead of the conventional wet etching with hydrofluoric acid, the quartz layer can be easily etched using the ICP dry-etching method. Then, the structure of the pure quartz material is obtained by removing the silicon wafer. In addition, the silicon layer can be processed into the appropriate structure. This aspect overcomes the difficulty of processing a complex structure of single-crystal quartz with different crystal orientations. Thin single-crystal quartz wafers of Z-cut with a thickness of less than 40 μm were obtained by using this method, and a complex three-dimensional structure with an 80 μm width was also acquired by the ICP etching of the quartz wafer. The method can be applied to make both crystal-oriented quartz-based sensors and actuators, such as quartz resonant accelerometers.