bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-gestational primary choriocarcinoma of the ovary presentation of a clinical case
Authors: Vargas-Hernandez Victor Manuel , Machuca-Hernandez Violeta Fabiola , Victor Manuel Vargas-Aguilar , Agustin Rodriguez Blaz , Jose Maria Tovar Rodriguez
Published: January 2022

Background: Ovarian germ cell tumors are derived from the primordial germ cells of the ovary, they can be benign or malignant. Non-gestational ovarian choriocarcinoma is extremely rare and aggressive that is of gestational or non-gestational origin, its prevalence is less than 0.6% of all ovarian germ cell tumors. Due to the rarity of the tumor, there is a lack of information on the clinical-pathological characteristics, diagnosis and treatment. Objective: A case of non-gestational ovarian choriocarcinoma and a review of the literature are presented. Clinical case: We present the case of a 20-year-old woman who presented with an acute abdomen, due to abdominal pain and distention, with scant vaginal bleeding and pain on cervical mobilization; An ultrasound was performed with a right annex with a lesion measuring 114x83x79mm and a total volume of 394cc, heterogeneous with linear images inside punctiform and human chorionic beta-gonadotropin levels, elevated 112.337 mUI/mL, the patient underwent an exploratory laparotomy with the finding of an ovarian tumor; performing salpingo-oophorectomy and the histopathological report of the definitive surgical specimen and immunohistochemical study, the diagnosis of non-gestational ovarian choriocarcinoma was made. Conclusion: Non-gestational choriocarcinoma is an extremely rare malignant neoplasm that can present clinically as an acute abdomen and requires differential diagnoses. Management is the combination of surgery and adjuvant chemotherapy, our patient responded.
[RETRACTED] Next Plant CBD Gummies Reviews: Updates 2022 - Shocking Revelation! v1
Authors: Plant CBD Gummies Next
Published: January 2022

[RETRACTED]

https://www.mynewsdesk.com/iexponet/pressreleases/next-plant-cbd-gummies-reviews-2022-new-dietary-ingredient-of-full-spectrum-gummies-3155753
Evaluation of Coronavirus Phobia and Depression in Patients With Cardiovascular Disease
Authors: CANSEL Neslihan , KARACA Yücel , YAĞIN Fatma Hilal
Published: January 2022

Objective: Although there are numerous studies examining the psychological effects of COVID-19 pandemic on the general population, the number of studies on individuals with cardiovascular disease is limited. This study aimed to determine coronavirus phobia and depressive symptoms and their possible associated factors in cardiovascular disease patients during the current pandemic period.
Material and methods: In this cross-sectional study, patients applied to the cardiology outpatient clinic due to a cardiovascular disease between November-December, 2020, and individuals without any cardiovascular diseases were included. Participants answered a questionnaire consisting of sociodemographic variables, Patient Health Questionnaire-9 (PHQ-9) and COVID-19 Phobia Scale (CP19-S).
Results: In total, 372 people participated. The CPS-19 and PHQ-9 total scores of the patient group were higher than the control group. Patients reported that they most afraid of someone in the family might infected with the coronavirus. PHQ-9 total scores of females, CP19-S and PHQ-9 total scores of those with a history of psychiatric illness were high. Psychological, somatic, social subscale scores, CP19-S and PHQ-9 total scores of married patients were lower than singles. High leveled-education increased CP19-S total, psychological and social sub-scores. While the psychological and somatic subscale scores of the smokers were high, their PHQ-9 total scores were low. Those admitted to intensive care due to COVID-19 reflected low economic subscale and CP19-S total scores. Correlation analysis detected a correlation between the CP19-S subscale, total scores and PHQ-9 total scores.
Conclusion: The COVID-19 pandemic has psychologically affected cardiovascular patients. Evaluation of this effect may guide the taking of measures that will contribute to the prognosis and mortality of patients with cardiovascular disease.
Цифровой этикет: вопросы методологии
Authors:   Санкт-Петербургский государственный электротехнический университет «ЛЭТИ», Мамина Р.И.
Published: January 2022

Показано, что цифровой этикет — это новый вид этикетной коммуникации, который формируется в пространстве Всемирной Глобальной паутины третьего поколения — Web 3.0, и, как следствие, функционирует как в онлайн, так и в оффлайн/онлайн режимах. Рассмотрены роль и значение цифрового этикета в условиях современных реалий, выделены основные направления его развития — это непосредственное общение в сети, взаимодействие с гаджетами, а также самопрезентации в сети. Специфика и особенности каждого направления рассмотрены в рамках цифрового этикета, как единой целостной системы. Подчеркивается, что новый вид этикета представляет собой современное междисциплинарное знание теоретико-прикладного характера, которое находится в стадии своего становления, поэтому с необходимостью требует внимания специалистов, представляющих как гуманитарное знание, так и знание новых и новейших информационно-коммуникативных технологий.
Избирательное социальное дистанцирование: технологии и коррекция
Authors:   Межрегиональная Межведомственная Интернет-Гостиная «Белая Речь», Рыбаков Д.Г. , Султанова Р.М. ,   Башкирский государственный университет, Гаязова Г.А. ,   Башкирский государственный университет
Published: January 2022

Развитие информационно-технического компонента социально-экономической, образовательной среды жизнедеятельности современного человека открывает новые возможности и отвечает изменяющимся потребностям детей, в том числе — имеющим ограниченные возможности здоровья. Сотрудничество учёных и специалистов, родителей таких детей и общественников позволяет актуализировать и более тонкие тенденции в развитии и запросах современных детей.
Borders as the ultimate (de)Fence of Identity: an ontological security approach to exclusionary populism in Italy and Spain
Authors: Cervi Laura , Tejedor Santiago
Published: January 2022

This paper looks at the discursive construction of the concept of border and its interaction with identity in two exclusionary populist movements: Lega in Italy and Vox in Spain. The study, based on the analysis of an ad hoc selection of discourses by the two parties’ leaders, applies clause-based semantic text analysis to detect the main discursive representations of the “us” and the “others” as threatening ontological security and the performative role played by borders as the ultimate (de)Fence for identity. Results show that Matteo Salvini focuses his discourse on the manipulation of physical space, representing Italy as the space for Italians and proposing to “close the borders” as the only way to stop the “invasion”. Santiago Abascal, on his side, constructs Spanish identity as inherently and proudly “anti-Islamic”. Borders, therefore, are invalicable for those considered incompatible with local values, namely “Muslims”, represented as a “natural threat” to Spanish identity.
The effect of neostigmine, hexamethonium and methyllycaconitine on large-conductance cation channels in the nuclear membrane of cerebellar purkinje neurons of rats
Authors:   Bogomolets Institute of Physiology NASU, Briantseva B.-M. , Tarnopolska O. ,   Taras Shevchenko national University of Kyiv, Kotyk O. ,   Bogomolets Institute of Physiology NASU, Kotliarova A. ,   Bogomolets Institute of Physiology NASU
Published: January 2022

Large-conductance cation channels (LCC-channels) were found in both (inner and outer) nuclear membranes of cerebellar Purkinje neurons. They are the most common type of intracellular spontaneously active ion channels among other identified. Their structure and physiological functions are still unknown, but the previous findings confirmed their sensitivity to a number of agonists/antagonists of nicotinic acetylcholine receptors. The purpose of the investigation was to estimate the effect of other regulators of the N-cholinoreceptors functioning – neostigmine, hexamethonium, and methyllycaconitine (MLA) on the LCC-channels in the nuclear membrane of cerebellar Purkinje neurons of rats. The effect of the agents was estimated based on changes in the following biophysical parameters: current amplitude, Po, channel flickering effect. Ion currents through single channels were registered using the patch-clamp technique in a nucleus-attached mode in voltage-clamp configuration. Among the studied substances, only MLA and hexamethonium influenced the LCC-channels functioning. Hexamethonium at a concentration of 2 mM reduced the Po of the LCC-channels by 46%. Under the influence of MLA, a slight effect of channel flickering was observed ("Poisson surprise" was 2.14 in the control and 3.81 under the influence of 200 μM of the substance respectively). No significant change of the biophysical characteristics of the LCC-channels under the influence of neostigmine was detected. Despite the low efficiency as LCC-channels blockers, the lack or only slight effect is a strong argument in favor of the substance usage in medicine due to their wide therapeutic potential. The severity of their effects is necessary for a comprehensive analysis of the effect patterns of the abovementioned substances on the molecular dynamics of the studied channels. The results will also be important for the identification or synthesis of new and more effective inhibitors of the LCC-channels.
TRANSFORMATION OF SINGLE-FAMILY RESIDENTIAL ZONE OF LVIV (THE CASE OF KOZELNYKY NEIGHBORHOOD)
Authors:   Ivan Franko National University of Lviv, HUDZELIAK Iryna
Published: January 2022

The single-family residential zone occupies an important place in the geospatial organization of the city of Lviv. According to the genesis, there are three types of single-family residential zone - former villages, which entered the administrative boundaries of the city in the 20th century; specially planned neighborhoods of single-family residence for different social groups of the population; small plots of single-family residence in the central part of the city in areas with a significant difference in height. The spatial transformation of Kozelnyky began in the 1860s with the construction of the railway and led to the loss of part of the agricultural land and several residential neighborhoods. Joining Lviv in 1959 radically changed the geospatial organization of Kozelnyky. Industrial construction and the construction of city roads through the village contributed to the emergence of internal barriers, which, consequently, increased social isolation within the neighborhood. In present, Kozelnyky is a buffer between the southern industrial zone and the new Sykhiv residential district. The neighborhood of Kozelnyky has stable borders, except for the south-eastern outskirts, where the construction of multi-storey buildings is the most intensive. Planning features of privatized land plots and narrow streets inhibit the penetration of urban architectural forms into rural construction. Construction compaction is mainly done by erecting annexes or new buildings on smallholdings without sharing them. The population of Kozelnyky is about 1163 people, most of them are descendants of Ukrainians deported from Poland. The transformation of the social structure is mainly due to the change of generations with minimal migration. The specific social structure, hybrid features of everyday life and sustainable attitudes of most people to preserve the existing way of life will further slow down the spatial transformation and contribute to the preservation of the rural cultural landscape of the neighborhood. The most acute problems of the neighborhood are: mostly dirt roads, lack of social facilities, in many households - centralized water supply and sewerage. Solving these problems requires significant investments and purposeful urban planning decisions that will facilitate the integration of the single-family residential zone into the urban environment. The abandoned area with technical water settlers may in the future be turned into a recreational zone for the residents of Kozelnyky district and the adjacent multi-storey buildings.
Manipulating the image of ‘Kyiv Rus’ in English-language publications of Russia Today (RT) media resource
Authors:   National University of Kyiv-Mohyla Academy, Moiseienko O. Yu. , Mazin D. M. ,   National University of Kyiv-Mohyla Academy
Published: January 2022

The article presents the results of the first analysis of linguistics strategies in representing and manipulating with the image of the medieval state “Kyivan Rus” in English-language publications of the Russia Today (RT), a multilingual Russian media resource propagating ideological views of the contemporary Russian state. The claims of the neoimperial Russian iscourse to exert an exclusive historical and political right over the ancient state of Kyivan Rus has been revealed. The application of the relevant media frames helped to identify linguistic and rhetorical tools aimed at building the planned ideology and ruling the reception of non-critical readers. The conducted analysis of the narratives based on the main contexts of using the image of “Kyivan Rus” in RT-publications helped to discover the list of the basic language strategies of manipulation with historical concepts, in particular the strategies of attacking and insulting the opponent, argumentum ad authority, dominating close-ended questions, or imposing forged relations between the signifier and its far-fetched interpretation. The context of the contemporary Russia and the context of the contemporary Ukraine were distinguished in the RT’s publications on Kyivan Rus. The research analysis confirms a targeted use of rhetorical tools by Russain media in order to voluntarily disrupt the historical discourse for neo-imperial objectives. The implemented study has also helped to clarify the immense difficulty of the Russian ideologists to prove their unique possessive legacy over the Kyivan Rus state, which is the direct predecessor of the Ukrainian state. The latter explains the aggressive and abusive nature of the publications in the Russia Today, undoubtedly oriented at non-critical readers. Further analysis of other English-language media messages will be useful to deepen the understanding of the exploited linguistic and rhetorical strategies in the contemporary ideological and political discourse.
TEACHING AND ASSESSMENT OF ENGLISH LISTENING-TO-WRITING IN UPPER SECONDARY SCHOOL: PEDAGOGICAL ADVANTAGES AND CHALLENGES
Authors:   Taras Shevchenko national University of Kyiv, Lavrenchuk Yuliia , Kavytska Tamara ,   Taras Shevchenko national University of Kyiv
Published: January 2022

As a life-long skill, writing plays a crucial role in post-secondary education and career. The nature and instruction of writing, however, have considerably changed over the last decade by shifting the focus onto integrated or source-based writing. On the one hand, combining writing and other skills – listening, for instance – enhances both skills; on the other hand, practicing writing together with listening develops critical thinking and rhetoric in learners. With its emphasis on knowledge transformation instead of knowledge transmission, source-based writing has captured the attention of researchers and language trainers in many educational settings, including secondary school. In the Ukrainian context, source-based writing in L2 education has been neglected on both theoretical and practical levels; as a result, it is excluded from most tertiary and secondary school writing courses as well as assessment. Therefore, the objective of this paper is to consider cognitive characteristics as well as pedagogical advantages and challenges of integrated listening and writing in an English classroom at upper secondary school. The research has revealed pedagogical values of integrated writing which include improved task authenticity, fair assessment, and the fact that integrated writing is not affected by the topic effect. The challenges are related to cognitive complexity of the integrated writing process and difficulties in interpreting the scores in the assessment process. The paper concludes that despite challenges, integrated listening and writing possesses strong pedagogical values as it enhances learners’ literacy, rhetoric as well as critical and creative thinking
NNOVATIVE FORMS OF TEACHING UKRAINIAN LITERATURE TO 7TH-GRADE STUDENTS OF SECONDARY SCHOOL
Authors:   Taras Shevchenko national University of Kyiv, Sorokina Nataliia , Lutsiv Yelizaveta ,   Taras Shevchenko national University of Kyiv
Published: January 2022

This research raises the important issues of the innovative education in general and the introduction of innovative organizational forms and techniques into the process of teaching Ukrainian literature in the 7th grade of a secondary school, in particular. In this sense, the paper aims at investigating the pedagogical essence and practical value of innovative forms of teaching in a secondary school. Thus, the authors consider the concept of «innovative lesson» in comparison to a classic lesson. The paper offers several classifications of modern innovative lessons used by teachers in the academic process and assume that there is no unified typology offered in literature. The implementation of innovative forms of teaching entails observing a range of requirements related to a lesson structure and aims that agree with every lesson stage, contextual and organizational aspects as well as teaching techniques. The paper discusses problems and difficulties that in-service teachers encounter when introducing innovative lessons in practice. Based on the assumptions made from literature and lesson observations conducted during teaching training practice (1 semester of 2020-2021 academic year) the innovative lesson-research was worked out and introduced to 7th graders. The survey on implementing the innovative lessons shows that both teachers-practitioners and students demonstrate positive perceptions of iinovative lessons and readiness to use them in practice. The conducted lesson-reseach «My Native Land Literature» with 7th graders has received positive feedbacks as well. The research results prove that innovative forms of teaching Ukrainian literature in a secondary school can be one of the effective ways to modernize educational process and motivate learners. The prospective of further research lies in creating a collection of innovative lessons in Ukrainian literature for 7 th grade students of a secondary school.
DEVELOPING READING SKILLS IN SECOND YEAR STUDENTS MAJORING IN SECONDARY EDUCATION IN A DISTANCE LEARNING ENVIRONMENT
Authors:   Taras Shevchenko national University of Kyiv, Druzhchenko Tetiana
Published: January 2022

The publication is a detailed lesson plan on the topic «Clothes and Fashion. Dress code» within the course of the English language currently taught in a distance learning environment. The lesson focuses on developing reading skills such as scanning and reading for details in the second-year students majoring in Secondary Education (CEFR level B1). The lesson is also aimed at developing students’ speaking and writing skills as well as enhancing vocabulary. It has been demonstrated how traditional peer interaction can be brought into the digital space via Zoom breakout rooms, enabling an essential increase in student talk time in the English classroom. The importance of giving clear task instructions followed by ICQs during the online class has been highlighted. The techniques for providing feedback during accuracy work and fluency work have been differentiated and applied.
PRACTICAL EFFICIENCY OF EQR METHOD FOR SOLVING GLOBAL OPTIMIZATION PROBLEMS
Authors:   University of Chemical Engineering, Dnipro, Ukraine, Kosolap A. I.
Published: January 2022

This article provides an analysis the practical effectiveness of the method of exact quadratic regularization. Significant computational experiments have been performed to solve the complex multi-modal test and practical problems. The results of computational experiments are compared with the best results obtained by existing methods of global optimization. Comparative analysis shows a much greater practical efficiency of the method of exact quadratic regularization.
Economic effects of promotion and relegation in parallel competitions
Authors: Gasparetto Thadeu , Barajas Angel
Published: January 2022

Previous research evidence some negative effects after league relegations. However, these works focused only on domestic league figures, overlooking that football clubs play in simultaneous tournaments. Therefore, the effects of relegation in a domestic league on those simultaneous championships remain unclear. Our dataset comprises twenty men’s Brazilian State Championships from 2013 to 2017. Panel Data Ordinary Least Squares models are employed as econometric techniques. The results suggest that the promotions to the second tier of the Brazilian League increase both attendance and revenues of clubs while relegations impact them negatively. Nonetheless, the promotion to the top tier produces no significant increase, which may indicate a potential adverse demand effect. Further research may inspect whether it happens in European football.
New trends for artificial intelligence development in medicine
Authors: Ryazanova Svetlana V. , Mazaev Vladimir P. , Komkov Artem A.
Published: January 2022

The article discusses the modern aspects of the use of artificial intelligence (AI) in medicine, the use of AI technologies in Russia and abroad. The article describes the limitations of the use of AI in various fields of medicine, discusses possible solutions, and develops electronic devices for remote and independent monitoring. The problems of information security and ethical issues of AI application are presented with the arguments of experts and expert organizations in AI issues, as well as the prospects for development and possible consequences of AI implementation. The possibilities of using AI in real clinical practice are explained, indicating the prospects for the future generation of doctors and their patients. Examples of data systematization for AI processing are given, which is a key factor in the reliability of predictive models obtained using AI.
Possibilities of neurocognitive rehabilitation using the dual tasks method in patients in the early postoperative period of coronary bypass surgery
Authors: Syrova Irina D. , Tarasova Irina V. , Trubnikova Olga A. , Sosnina Anastasia S. , Lozhkina Olga A. , Belik Ekaterina V. , Dyleva Yulia A. , Temnikova Tatiana B. , Frolov Alexey V. , Gruzdeva Olga V. , Barbarash Olga L.
Published: January 2022

Background. Previously, it has been demonstrated that the use of the dual-task method (performance cognitive and motor tasks simultaneously) in cognitive rehabilitation provides sustainable improvements in cognitive and motor functions. However, the effectiveness of the dual-task method in cardiac surgery patients has not been studied enough yet.
Aim. To evaluate the effectiveness of the training for recovering cognitive function using a computer program of dual tasks in the early postoperative period of on-pump coronary artery bypass surgery (CABG).
Material and methods. Sixty-two patients aged 64 [60; 69] years were examined before surgery and divided into two groups: with postoperative cognitive training (n=29) and without cognitive rehabilitation (n=33). The extended neuropsychological testing was performed 23 days before and 89 days after CABG to assess the psychomotor and executive functions (neurodynamic), attention and short-term memory, as well as the serum concentrations of markers of brain damage: neuron-specific enolase and S100 protein were measured.
Results. The data of preoperative extended neuropsychological testing did not demonstrate between-group differences. At 810 days after CABG, 20% decrease of the cognitive indicators was detected in patients of both groups. In the group with cognitive training, the number of patients with impaired memory, attention and neurodynamics was significantly lower than in the group without training. Also, in patients who underwent cognitive rehabilitation, there was no increase in the concentrations of neuron-specific enolase and calcium-binding protein S100 compared to preoperative values, in contrast to patients without rehabilitation.
Conclusion. The use of dual tasks computer program demonstrated a decrease in the severity of cognitive impairment after surgery.
Nursing profoundly premature newborns with artificial placentae: a review
Authors: Oyedele Akinyemi , Oyedele Morakinyo , Murashko Andrey V.
Published: January 2022

Neonatal mortality and morbidity are substantial issues affecting the maternal healthcare sector. Extremely premature infants, notably those born before the 28-week mark, experience significant morbidity and mortality rates during neonatal care. This is a result of developmental immaturity and iatrogenic injury. Several attempts have been made to develop a womb-like environment to mimic uteroplacental physiology, but limited success has been noted over the last decade. This review aims to summarize the current literature on improved techniques implemented in creating an artificial placenta, the principles of these procedures, and their limitations. Our findings indicate that implementing techniques that closely mimic uteroplacental pathophysiology is crucial in decreasing the excessive neonatal mortality and morbidity rates seen in extremely premature infants.
Encapsulated necrotic pancreatitis
Authors: Kitavina Svetlana I. , Petrovichev Victor S. , Ermakov Aleksandr N. , Ermakov Nikolay A. , Nikitin Igor G.
Published: January 2022

This study presents a rare clinical case of encapsulated necrotic pancreatitis, which was a complication of acute pancreatitis that arose against the background of alimentary disorders. The aspects of the semiotics of radiation diagnostic methods in the follow-up control of these pathologies were presented.
This case is notable for the manifestation of diseases upon hospital admission, as in the classical edematous form of acute pancreatitis, with a further increase in negative dynamics. This demonstrated the possible stepwise disease development, accompanied by a series of follow-up computed tomography between the clinical and morphological phases of acute pancreatitis and before the formation of pancreatic necrosis, which was complicated by sequestration of the pancreatic body with peripancreatic abscess formation. Afterward, the therapeutic paradigm was changed, and the place of the conservative approach was taken by active surgical tactics, followed by repeated manipulations and follow-up computed tomography and magnetic resonance until the improvement of the patients condition.
Role of the GRIN1 gene polymorphism in the formation of post-traumatic epilepsy
Authors: Gazaryan Lilit M. , Selyanina Natalia V. , Karakulova Yuliya V. , Sosnin Dmitriy Y.
Published: January 2022

Introduction: NMDA receptors are involved in the pathogenesis of seizures, as it subunit is coded for by the GRIN1 gene. Different GRIN1 mutations are known in patients with different forms of epilepsy and encephalopathy. However, no data are available on the participation of the GRIN1 gene and its polymorphisms in the development of post-traumatic epilepsy (PTE). Aim: To determine the influence of single-nucleotide rs1126442 polymorphism of GRIN1 on the risk of PTE formation. Materials and methods: A total of 140 patients were examined, which included 69 patients with PTE and 71 patients with genetic epilepsy. All patients underwent a comprehensive examination, with evaluation of history, neurological status, electroencephalography (EEG) and neuroimaging results, and genotyping of blood samples by real-time polymerase chain reaction. The control sample for genetic examination was venous blood from 60 healthy individuals. Results: Focal seizures with transition to bilateral and tonicclonic seizures were predominant in the PTE group. Neuroimaging revealed dystrophic, cystic, and cystogliotic alterations and signs of external hydrocephaly. EEG recorded interictal and ictal epileptiform activity and slowing of theta waves. Genotyping by rs1126442 polymorphism of GRIN1 revealed predominance of heterozygous G/A and homozygous A/A genotypes in patients with PTE in the codominant (odds ratio (OD)=3.43; 95% confidence index (CI) 1.567.55; p=0.0047), dominant (OR=3.24; 95% CI 1.576.68; p=0.0011), and superdominant (OR=2.90; 95% CI 1.366.22; p=0.0048) inheritance models. The carriage of heterozygous G/A rs1126442 genotype of GRIN1 was associated with an epileptiform activity in the EEG of all patients with epilepsy (OR=2.40; 95% CI 1.115.20; p=0.024). Conclusion: The carriage of heterozygous G/A genotype and homozygous A/A rs 1126442 genotype of GRIN1 in the dominant and codominant inheritance models is associated with a high risk of development of epilepsy after craniocerebral trauma. The carriage of heterozygous G/A rs 1126442 genotype of GRIN1 is associated with an epileptiform activity in EEG.
Pharmacoepidemiology of the administration of antihypertensive drugs by doctors in the Voronezh region in comparison with the results of the PYTHAGOR IV study
Authors: Kartashova Elvira S. , Batischeva Galina Aleksandrovna , Zhdanova Olga A. , Sharapova Yulia A.
Published: January 2022

Background: To examine the pharmacoepidemiology of treatment for arterial hypertension (AH) in Russia, the PYTHAGOR study has been conducted since 2001, including PYTHAGOR III (20012002), PYTHAGOR III (2008), and PYTHAGOR IV (2013). Increasing the role of doctors of outpatient care in the pharmacotherapy of patients with AH creates prerequisites for conducting new pharmacoepidemiological studies.
Aim: To investigate the structure of prescriptions of antihypertensive drugs (AHD) by outpatient doctors at the regional level in comparison with the results of PYTHAGOR IV pharmacoepidemiological study.
Materials and methods: In 2018, a survey was conducted in the Voronezh region among 104 doctors, including 58 general practitioners (55.8%), 37 therapists (35.6%), and four cardiologists (3.8%). The average age of the doctors was 45.7 13.5 years, the accumulated period of work was 21.0 13.7 years, and the period of work in an outpatient clinic was 16.6 12.4 years.
Results: In the structure of doctors pREFERENCES in selecting free combinations of AHD, doctors preferred angiotensin-converting enzyme inhibitors (iACE; 90.3%), but they were prescribed more rarely than that in PYTHAGOR IV study (93.8%). The remaining AHD groups were used by doctors of the VR more often than in the PYTHAGOR IV study: beta-adrenoblockers, 89.4% (PYTHAGOR IV, 73.1%); diuretics, 88.4% (73.2%); calcium antagonists (CА), 86.5% (67.3%); angiotensin II receptor blockers (ARB), 81.7% (62.1%); imidazoline receptor agonists, 57.6% (13.3%). In the selection of fixed combinations of AHD: iACE or ARB with a diuretic was used in 71.9% and 36.4%, respectively, and iACE with CA in 46.2%. In the PYTHAGOR IV study, these combinations were used more rarely, i.e., in 33.3%, 28.0%, and 24.1%, respectively.
Conclusion: The data obtained indicate adherence of doctors to modern clinical guidelines for the pharmacotherapy of AH.
Clinical case of an unusual course of coronavirus infection in patient with chronic disseminated pulmonary tuberculosis and human immunodeficiency virus infection
Authors: Dobin Vitaly L. , Gorbunov Alexei V. , Muratov Yevgeniy N.
Published: January 2022

Introduction: The coronavirus 2019 (COVID-19) pandemic demonstrated a negative influence on many underlying diseases, their course, and prognosis. A combined course of active tuberculosis, human immunodeficiency virus (HIV) infection, and COVID-19 is a rare case in the routine clinical practice; therefore, it is of scientific and practical interest. In a 41-year-old patient with severe chronic disseminated pulmonary tuberculosis and HIV infection, presence of tuberculosis mycobacteria, resistance to streptomycin and isoniazid, chronic respiratory failure, cachexia, and immunodeficiency, COVID-19 was manifested only by the detection of SARS-Cov-2 virus from the nasopharynx and did not influence the treatment and prognosis of tuberculosis.
Conclusion: The described case of a combination of active tuberculosis with HIV infection and COVID-19 demonstrated that effective treatment of specific tuberculosis process is quite possible.
Optimal periods for coronary artery bypass surgery on working heart in patients with stenosis of left main coronary artery and acute coronary syndrome
Authors: Staroverov Ilia N. , Staroverov Ivan N. , Churakov Stanislav O. , Lonchakova Oksana M.
Published: January 2022

Introduction: The treatment strategies of patients with stenosis of the left main coronary artery (LMCA) and acute coronary syndrome (ACS) is being debated. One of the key problems is the selection of the optimal time for coronary artery bypass surgery (CABS) in these patients.
Aim: To analyze different periods of revascularization of the myocardium by CABS on a working heart in patients with LMCA stenosis and ACS.
Materials and methods: A prospective analysis of treatment of 112 patients with LMCA stenosis ( 50%) and ACS was performed. Patients were divided to three groups depending on the time of surgical treatment: upto 7 days after occurrence of ACS, 18 (16.1%, group1) patients; 814 days, 38 (33.9%, group2) patients; 14 days, 56 (50%, group3) patients. The average time of ACS-CABS in all patients was 15 days. The groups were comparable in terms of the main preoperative parameters, except for EuroSCORE II and GRACE scale that were predominant in the early periods of CABS.
Results: LMCA subocclusion (stenosis 90%) with coexistence of anginal syndrome at rest was observed in more than half of patients with surgery upto 7 days (56%, p=0.019). The surgery duration, blood loss through drains, number of days in the resuscitation unit, duration of artificial lung ventilation, and use of vasopressor support were not significantly different. The revascularization index was higher in surgeries conducted within 7 days than in surgeries performed within 814 days (2.33 0.59 versus 1.89 0.65, p=0.02). The evaluation of the dynamics of the functional parameters of the myocardium showed a greater increase in ejection fraction in group1 when compared with group3 after surgery (p=0.036). In the evaluation of the end-diastolic volume of the left ventricle, the average reductions were 16 mL, 14 mL, and 8.5 mL, respectively, without any significant differences among the groups. The rate of intrahospital lethality was highest in group3 (.4%), followed by group2 (2.6%). No fatal outcomes were noted in surgeries conducted in upto 7 days (p 0.050).
Conclusion: Early CABS performed upto 7 days have similar immediate results to delayed ones and considerably improves the contractile ability of the myocardium in patients with ACS and LMCA stenosis.
Variability of arterial pressure and cardiac rhythm in patients with coronary heart disease and diabetes mellitus: Effect of sodium-glucose co-transporter 2 inhibitor
Authors: Kotskaya Anastasia V. , Salaychuk Elizaveta V. , Kudinov Vladimir I. , Terentyev Vladimir P. , Lankina Maria S.
Published: January 2022

Introduction: A factor that worsens the course of coronary heart disease (CHD) in patients with type 2 diabetes mellitus (DM2) is cardiovascular autonomic neuropathy (CAN), in which the risk of sudden death increases fivefold. The prevalence of CAN in patients with both CHD and DM2 may reach 60%. Classic cardiovascular tests (CCT) do not permit identification of CAN at the preclinical stage. A modern method of treatment for DM2 uses sodium-glucose co-transporter 2 inhibitors, which have confirmed cardioprotective effects.
Aim: To analyze the prevalence of alterations of arterial pressure variability (APV) and of heart rhythm variability (HRV) in patients with both CHD and DM2 and the effect of empagliflozin on these parameters.
Materials and methods: A total of 210 patients aged 64.5 6.7 years (103 men) with both CHD and DM2 were examined (group1). Anthropometric and biochemical parameters were analyzed, electrocardiogram and arterial pressure were monitored daily, and CCT was performed. For comparison, 64 patients with CHD with no alterations in the carbohydrate metabolism were examined (group2, n=64, aged 66.4 2.3 years). Further, among patients in group1, patients with impaired HRV and APV were selected, but they had CCT scores 4.0, and they were divided into group1G (n=22) where empagliflozin was added (1025 mg/day) and group1C (n=20) where the previous therapy was continued.
Results: CAN was detected in 22% of patients with CHD and DM2, and all patients had impaired HRV and ADV. Deviations of HRV and APV parameters with normal CCT scores ( 4.0) were detected in 43% of the patients. Within 6 months of treatment with empagliflozin, the HbA1c level decreased from 8.38% 0.56% to 6.9% 0.26% (p 0.05); in the groupwithout empagliflozin treatment, it decreased from 8.28% 0.32% to 7.30% 0.29% (p 0.05). In the empagliflozin group, the average heart rate per day decreased from 86.7 2.4 to 76.7 2.1 beats/min (p 0.05), the circadian index increased from 1.19 0.02 to 1.30 0.01 (p 0.05), the SDNN increased from 106.1 2.21 to 114.03 2.34 ms (p 0.05), and the systolic arterial pressure variability index decreased from 22.9% 1.7% to 16.4% 1.9% at daytime (p 0.05) and from 16.8% 2.2% to 12.3% 2.6% at nighttime (p 0.05).
Conclusion: The identified alterations of HRV and APV parameters may be manifestations of CAN, and CCT score 4.0 may indicate the preclinical stage. Positive dynamics of HRV and APV was recorded with empagliflozin therapy, which improved the functional condition of the autonomic nervous system.
Features of geriatric status of patients during the pandemic COVID-19
Authors: Bogdanova Tatiana A.
Published: January 2022

BACKGROUND: In older patients, the new coronavirus infection may present with atypical symptoms such as delirium, dizziness, and unusual fatigue. At the same time, restriction of movement and fear of infection during the COVID-19 pandemic affect decreased physical activity and increased frequency of anxiety, depression and sleep disorders. Due to these symptoms and conditions are significant falls risk factors, the risk of falls and the frequency of falls in older adults is expected to increase in the near future.
AIM: To identify the new cases of COVID-19 infection in patients 65 and older and to determine the incidence and risk factors of falls in patients who have had COVID-19.
MATERIALS AND METHODS: The study involved 86 patients territorially attached to the Family Medicine Center of the North-Western State Medical University named after I.I. Mechnikov. All patients who took part in the study had COVID-19 infection. 48 of them (available at the time of the study) were interviewed in order to establish falls risk factors and cases of falls. The control group consisted of 58 patients who had not had COVID-19 infection. Analysis of the outpatient records of all study participants, screening of frailty, questionnaires, assessment of emotional status, and detection of sleep disorders were performed.
RESULTS: The frequency of neurological symptoms increased in COVID-19 infected patients: dizziness (p 0.05), unsteady gait (p 0.05), impaired or lost sense of smell (anosmia) and loss of taste (dysgeusia) (p 0.05), sleep disorders, symptoms of depression and anxiety. The proportion of patients with decreased body weight was significantly higher after the disease (p = 0.0127). Patients in the control group also had a high frequency of complaints of memory and attention disorders, decreased vision, symptoms of anxiety and depression, and difficulty moving around. The incidence of frailty symptoms in the control group was 63.1% (n = 53). Patients who have not been infected with COVID-19 were significantly more likely to report imbalanced walking 60.3% (n = 35) than patients who had COVID-19 infection 37.5% (n = 18) (p = 0.002). One-third of COVID-19 survivors had elevated plasma glucose levels for the first time, 3.4% had worsened diabetes, and 5.8% of participants were rehospitalized within 3 months of illness.
CONCLUSIONS: The study demonstrated a high incidence of neurological symptoms in participants who had COVID-19: dizziness, unstable gait, sleep disorders, symptoms of depression and anxiety, and weight loss complaints. Patients who had not had COVID-19 infection showed a high frequency of complaints of memory and attention impairment, decreased vision, symptoms of anxiety and depression, and imbalanced walking. The syndromes and symptoms identified in both groups were risk factors for falls and the risk of developing a fear of falling.
A Rediscovered Syriac Amulet from Turfan in the Collection of the Hermitage Museum
Authors: Dickens Mark , Smelova Natalia
Published: January 2022

Item ВДсэ-524 in the State Hermitage Museum in St. Petersburg is an amulet scroll written in Syriac which was discovered by the Second German Turfan Expedition (19041905) and kept afterwards in the Museum of Ethnology (Museum fr Vlkerkunde) in Berlin. The artifact originates in the Turkic-speaking Christian milieu of the Turfan Oasis, probably from the Mongol period. The text, however, reflects a long tradition of magical literature that goes back to ancient Mesopotamia and can be categorised as a piece of apotropaic (protective) magic. The article contains an edition of the Syriac text with translation and a discussion of its place of discovery, its overall composition and specific words and expressions found in the text. The authors point out likely connections between the Hermitage amulet and the Turfan fragments SyrHT 274276 kept in the Staatsbibliothek zu Berlin Preuischer Kulturbesitz and briefly discuss its similarity with amulet H彩101 discovered in Qara Qoto by the 19831984 expedition of the Institute of Cultural Relics, Inner Mongolia Academy of Social Sciences.
Emotions and International Relations
Authors: Kotsur G.
Published: January 2022

This article is the part of the recent emotional turn when the scholars of social science are paying more attention to the study of collective emotions in international affairs. The former dominance of the biological and essentialist paradigms in this field were replaced by a number of culture-centered approaches based on social constructivism, which were elaborated within two pioneering disciplines – anthropology of emotions and history of emotions. The influence of such a scientific revolution included the key axis of the common – unique with an emphasis on the latter. The IR has been also affected by an emotional turn when the field of constructivist emotional studies had been established in the early 2000s. The object of this work is the transnational structural common – collective emotional patterns that have recurrent nature and emerge beyond state borders. This part of reality has not been conceptualized by scholars. Therefore, the aim of the article is to fill an epistemological vacuum and outline the ways for conceptualization of transnational structural common. It is IR that seem to be the most suitable field to do this. The empirical case of the crisis response after terrorist attacks are analyzed as the example of the transnational structural common. This case is explored by the author through the framework of "emotion culture" by S. Koschut in combination with the concept of "emotives" by W. Reddy. Speeches by the leaders of Israel, the United States, Russia, India and France after six terrorist attacks from 1972 to 2015 allow to identify an integrated tripartite emotional structure, which is observed in each of the cases. This structure includes an emotive of pity; compensatory structure with the emotives of fighting fear through reciprocal determination; finally, an emotive of solidarity. This discursive structure functions in a stable way because the emotional code connects the type of event (terrorist attack) with the cultural script (tripartite structure). Finally, some approaches in sociological institutionalism would enrich future studies of emotion culture.
A review on open bite
Authors: Munjal Anshul , Ali Adeeba , Abraham Sharon Ann , Jini Bater
Published: January 2022

Normal occlusion is analyzed in three dimensions- sagittal, vertical and transverse, and any deviation in these three parameters are further attributed to skeletal, dental, habitual or a combination of the three factors. Open bite characterized by insufficient or absence of contact between anterior and/or posterior teeth have been found to be one of the most complex vertical malocclusion to treat with high tendency for relapse in both surgical and non surgical intervention. The aim of the article is to arrive at a precise diagnosis and classify with early intervention using the most appropriate treatment and retention modalities to achieve long term functional and esthetic goals.
¿Democracia o dictadura? Visiones de la revolución cubana en la Cadena García Valseca, 1959-1969
Authors: Gil Pérez Anderson Paul , Sánchez Parra Sergio Arturo
Published: January 2022

El objetivo del artículo es analizar los cambios en la cobertura informativa de la organización periodística Cadena García Valseca acerca de la revolución cubana. A partir de la revisión e interpretación cualitativa de fuentes de prensa e historiografía se determina que la revolución cubana fue presentada con dos visiones. Una primera que celebró el triunfo de Fidel Castro, Camilo Cienfuegos y Ernesto Guevara, sobre la dictadura de Fulgencio Batista como una victoria de la democracia en América Latina. La segunda visión que deslegitimó el proceso revolucionario en Cuba como una dictadura comunista que implicó un “aparente” riesgo para la estabilidad del continente y en especial de México. De esta manera, se ofrece una perspectiva desde la prensa mexicana que aporta mayores matices en un proceso siempre vigente en la nueva historia política latinoamericana.
Karakteristik Mikoriza Arbuskula Tanaman Serai Wangi (Cymbopogon nardus L.) di Lapangan Ternaungi dan Tidak Ternaungi
Authors: Sukarno Nampiah , Laelandi Rahayu , Qayim Ibnu , Amelya Mega Putri
Published: January 2022

Arbuscular mycorrhiza (AM) characteristics of citronella grass in the field have not been reported. This research aimed to study the AM characteristics of citronella grass grown in unshaded and shaded fields. The roots of citronella grass were collected from citronella grass plantations in Cianjur, West Java. The root samples were analyzed for AM structures, namely entry points, intercellular hyphae, arbuscules, and vesicles. The results showed that the citronella grass form AM colonization. The quality of root colonization differed between the two cultivation systems. The unshaded citronella grass had higher root colonization compared to shaded citronella grass. In the unshaded citronella grass, the number of arbuscules was 7 per cm of root length, whereas in the shaded citronella grass was 4 per cm of root length. The types of arbuscules observed were arum and intermediate. There were no differences in the number of entry points in the two cultivated systems, which was 3,5 entry points per cm of root length. The numbers of vesicles and internal hyphae in unshaded citronella grass were lower than that of in the shaded citronella grass. In the unshaded citronella grass, the number of vesicles and intracellular hyphae were 1,5 and 8,5 per cm root length, whereas in the shaded citronella grass were 3,5 and 11 per cm root length, respectively. Shading plants grown in the field were bamboo, banana, coffee, tea, and sugar palm. All the shading plants formed AM symbiosis with a colonization value of 7 to 30%. This research indicates that arbuscular mycorrhiza is an important component in the citronella grass cultivation in unshaded and shaded fields.

 

Keywords: Arbuscule, entry point, intercellular hyphae, root colonization, vesicle