bluuebunny/crossref_metadata_2025 huggingface dataset:
Review on artificial intelligence application in structural earthquake engineering
Authors: Abdul Satar Qayoumi  , Haseebullah Shalizi  , Mazhar A. Dhankot
Published: January 2025

Artificial Intelligence (AI) has brought a transformative shift to seismic engineering during past decade, enabling engineers to address complex challenges with unprecedented precision and efficiency. By leveraging machine learning (ML) and deep learning (DL) technologies, researchers are redefining seismic analysis, structural response prediction, and damage assessment. AI-driven methods such as artificial neural networks (ANNs) and convolutional neural networks (CNNs) have proven highly effective in analyzing seismic data and predicting structural performance during earthquakes. These tools process vast datasets collected from global seismic networks, facilitating real-time monitoring and more accurate damage assessments. They predict structural responses with remarkable precision, optimize designs for resilience, and better prepare for natural forces Furthermore, advancements like physics-informed neural networks (PiNNs) integrate engineering principles with AI, providing models that are both reliable and interpretable. This paper reviews the advancements of AI application in earthquake engineering during the past decade (Open Access Articles), current challenges and future directions.
Evaluation of the cytotoxicity of the aqueous extract of Allium sativum (Lilliaceae) on macrophage cells of the Raw-264.7 line by the cytotoxic concentration method (CC50)
Authors: Marc Germain Minoue Kuum  , Celestin Ayangma  , Felix Luther Ndoung  , Gisele Ateba Nke  , Sida Magloire Biwole
Published: January 2025

The present work aims to identify, determine the presence and quantities of the chemical groups contained in the aqueous extract of Allium sativum, and to evaluate its cytotoxicity in order to justify its multiple biological activities and its therapeutic indications in traditional medicine for better evaluation in human health. An in vitro study was carried out at the bacteriology laboratory of the Central Hospital of Yaoundé and at the Nutrition and Nutritional Biochemistry laboratory of the University of Yaoundé 1. An aqueous extract of Allium sativum was prepared by cold maceration. To highlight the presence or absence of secondary metabolites, specific qualitative phytochemical tests based on discoloration, precipitation or turbidity reactions were carried out, using the methods of Pascual et al. [1] and [2]. The characterization of the chemical constituents was done by specific reactions. The investigation for these phytochemical groups were carried out on the aqueous extract following the protocols usually used the methods of Singleton et al. [3], Ghorai et al. [4] and Fernanda et al. [5]. The in vitro cytotoxicity of the extract was evaluated on Raw cells 264.7 murine macrophage cell lines, provided by the Noguchi Memorial Institute for Medical Research at the University of Ghana. The cells were maintained in continuous culture in the laboratory and subsequently used for the cytotoxicity test. The evaluation of the cytotoxicity of the aqueous extract of Allium sativum and the positive control (Dimethyl Sulfoxide) were carried out on macrophage cells of the Raw-264.7 line using the cytotoxic concentration method (CC50). The aqueous extract had a yield of 37.84%. The CC50 value for the aqueous extract of Allium sativum is greater than 1000 μg/mL, while for Dimethyl Sulfoxide (5%) the CC50 value is 0.08275 ± 0.00367 μg/mL. At the end of this study, we were able to evaluate the phytochemical screening of the plant. It appears that our extract contains high amounts of polyphenols, tannins, flavonoids and terpenoids. These results suggest an interesting potential of our extract with potential antimicrobial, anti-inflammatory, analgesic, vasculoprotective, antispasmodic, antioxidant and/or immunomodulatory properties. No significant cytotoxic effect of the aqueous extract of Allium sativum was observed on murine macrophages. These results suggest that the plant can be used in traditional therapeutic treatments. Furthermore, a more in-depth study by phytochemical sorting followed by chromatography will allow us to isolate the active molecules of Allium sativum in order to justify its multiple biological activities, its therapeutic indications in traditional medicine and in order to offer an available and affordable phytomedicine. accessible to the global community.
UPAYA MENINGKATKAN KUALITAS LAYANAN MELALUI APLIKASI DIGITAL SIC PROSPERITY DI SEMEN INDONESIA COOPERATIVE
Authors: Rohman Wahyu Mutiara , Sukaris Sukaris
Published: January 2025

Tujuan dari penelitian adalah untuk menganalisis fitur dan manfaat aplikasi digital Semen Indonesia Cooperative Prosperity, penelitian ini bertujuan untuk menganalisis kualitas layanan yang diberikan dengan adanya aplikasi digital SIC Prosperity, dan menganalisis upaya untuk meningkatkan kualitas layanan yang diberikan dengan adanya aplikasi digital Semen Indonesia Cooperative Prosperity. Menggunakan teknik deskriptif kualitastif berdasarkan data primer dan sekunder. Metode pengumpulan data didasarkan pada wawancara terstruktur dengan pertanyaan yang telah disiapkan sebelumnya dari informasi yang diperoleh. Hasil menunjukkan bahwa upaya meningkatkan kualitas layanan dengan pengembangan fitur-fitur seperti koneksi simpanan sukarela untuk berbelanja, penarikan simpanan online, dan fitur pembayaran untuk kebutuhan sehari-hari, fitur mutasi simpanan dan simulasi pembiayaan yang lebih rinci meningkatkan transparansi dan perencanaan keuangan, partisipasi anggota dalam pengambilan keputusan diperkuat dengan adanya entry surat suara online pada Rapat Anggota Tahunan, memperluas kerjasama dengan ritel dan meningkatkan kompetensi sumber daya manusia dalam pengelolaan teknologi. Namun, pelayanan yang diberikan dengan adanya aplikasi digital Semen Indonesia Cooperative Prosperity cukup baik sesuai dengan 5 dimensi kualitas layanan (reliability, tangible, responsiveness, assurance dan emphty). Pengembangan fitur dalam aplikasi digital Semen Indonesia Cooperative Prosperity tidak hanya memenuhi kebutuhan anggota tetapi juga meningkatkan pengalaman layanan secara keseluruhan. Dengan memperkuat transparansi, fleksibilitas, dan partisipasi anggota, serta meningkatkan kerjasama dengan ritel dan kompetensi Sumber Daya Manusia, Semen Indonesia Cooperative Prosperity berpotensi untuk menjadi solusi keuangan digital yang lebih inovatif dan efektif. Upaya ini menunjukkan komitmen yang kuat untuk memberikan layanan yang berkualitas dan relevan bagi seluruh anggota.
The Influence of Tax Sanctions and Tax Rates on Perceptions of Tax Evade Agency with Tax Information Technology as a Moderation Variable in KPP Pratama Jombang
Authors: Pramiana Omi , Nabila Fikrotun , Sucipto Beni
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh sanksi pajak dan tarif pajak terhadap persepsi penggelapan pajak badan dengan teknologi informasi sebagai variabel moderasi. Populasi yang digunakan dalam penelitian ini adalah seluruh wajib pajak badan yang terdaftar dan telah melakukan kewajiban perpajakannya di KPP Pratama Jombang masa pajak tahun 2022. Metode pemilihan sampel yang digunakan dengan menggunakan rumus Slovin dan diperoleh 100 sampel. Teknik analisis data yang digunakan adalah analisis dengan SmartPLS 4.0. Hasil penelitian ini menunjukkan bahwa sanksi pajak berpengaruh negatif tidak signifikan terhadap persepsi penggelapan pajak badan, tarif pajak berpengaruh positif signifikan terhadap persepsi penggelapan pajak badan, teknologi informasi tidak dapat memoderasi atau memperlemah pengaruh variabel sanksi pajak terhadap variabel persepsi penggelapan pajak badan, dan teknologi informasi dapat memoderasi atau memperkuat pengaruh variabel tarif pajak terhadap variabel persepsi penggelapan pajak badan.
The Effect of Green Accounting on Financial Performance with Environmental Performance as a Mediation Variable
Authors: Pramiana Omi , Indrasah Fifi , Suprapto Sugeng , Aminin Aminin
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh green accounting terhadap kinerja keuangan dengan kinerja lingkungan sebagai variabel mediasi pada perusahaan manufaktur sektor barang konsumen primer yang terdaftar di Bursa Efek Indonesia (BEI) periode 2021-2023. Penelitian ini menggunakan metode pendekatan kuantitatif asosiatif, dengan jumlah sampel yang diperoleh dengan metode purposive sampling sebanyak 36 perusahaan dengan jumlah data yang digunakan sebanyak 108 data yang diperoleh dari laporan tahunan (annual report) atau laporan keberlanjutan (sustainability report) pada masing-masing perusahaan. Teknik analisis data pada penelitian ini yaitu uji analisis jalur dengan program SPSS 25. Berdasarkan hasil pada penelitian ini menunjukkan bahwa green accounting berpengaruh positif terhadap kinerja keuangan, green accounting berpengaruh positif terhadap kinerja lingkungan, kinerja lingkungan berpengaruh positif terhadap kinerja keuangan, dan kinerja lingkungan memediasi sebagian (partial mediation) pengaruh green accounting terhadap kinerja keuangan.
PENGOLAHAN MINYAK JELANTAH UNTUK BAHAN DASAR PEMBUATAN SABUN CUCI PADA IBU-IBU RUMAH TANGGA
Authors: Nurfajriah  , Sari Santika , Anggraini Silvia , Zidane Mohammad , Fitriani Alyssa , Ad’hania Faizha , Farhan Inarta Muhammad
Published: January 2025

Used cooking oil is a serious problem for the environment. It is expected that its management can be regulated properly. People in Kampung Pulo do not know well about cooking oil management. The repeated use of cooking oil is in fact bad for health. Through this program, it is hoped that the community can find out how to process used cooking oil into soap economically. The method of implementing the activity begins with the problem discussion stage, socialization of the dangers of used cooking oil, soap making training, and activity evaluation. The results of the activity obtained that the community can know insights related to the dangers of used cooking oil well and its processing into laundry soap that can be used in household activities. It is hoped that the implementation of the program can be sustainable and even generate income for the community through soap products that have selling value
PENDAMPINGAN PENCEGAHAN KANKER PAYUDARA MELALUI PEMERIKSAAN PAYUDARA SENDIRI (SADARI) PADA REMAJA
Authors: Riski Akbarani  , Faiza Eva Inayatul , Alfia Hildayanti Rezha
Published: January 2025

Breast cancer is a health problem experienced by women throughout the world. This incident can occur at puberty, but is more common at older ages. Early detection is a very important first step to find out early the presence of a tumor or lump in the breast so that it can reduce the death rate due to cancer. The earlier breast cancer is found, the easier it will be to treat it. The aim of this activity is to increase the knowledge of young women about breast self-examination to detect breast cancer early. The method used in the initial stage was a survey, the second stage was lecture and practice, and the third stage was evaluation. The result is an increase in knowledge about breast self-examination, but there is still a need for socialization and motivation about the importance of regular breast self-examination for early detection of breast cancer.
DIGITALISASI PEMASARAN DAN SISTEM KEUANGAN PADA INDUSTRI RUMAH TANGGA COCONUT OIL KEDIRI
Authors: Irawan Mohammad Isa , Mukhlash Imam , Rukmini Meme , Hendy  , Hidayat Nurul , Rukmi Alvida Mustika , Iqbal Mohammad , Probojati Rasyadan Taufiq
Published: January 2025

Industri rumah tangga (IRT) minyak kelapa d’Hayfa Sukses Berkah memproduksi minyak kelapa murni Abila. Minyak kelapa yang dihasilkan memiliki kualitas yang tidak kalah baik dengan minyak kelapa yang dihasilkan industri besar. Beberapa kendala usaha yang dihadapi diantaranya sistem keuangan usaha yang belum tertata dan minimnya pemahaman pemilik dan staf dalam membuat laporan keuangan membuat usaha ini sulit berkembang. Tercampurnya keuangan usaha dan rumah tangga juga menjadi kendala internal. Selain memproduksi minya kelapa murni, dHayfa Sukses Berkah juga memiliki produk-produk turunan berbahan dasar minyak kelapa yang belum banyak diketahui masyarakat. Kegiatan pengabdian masyarakat ini dikembangkan sebuah sistem keuangan terkomputerisasi dan pemasaran digital bagi produk minyak kelapa Abila dan produk turunannya. Perkembangan sistem keuangan terkomputerisasi menunjukkan dampak positif dalam pengelolaan mitra. Pemanfaatan marketplace menunjukkan potensi dalam memperluas jangkauan pasar dan meningkatkan penjualan.
AUTOMATIC ELECTROPLATING CHROME DAN DIGITALISASI PEMASARAN : INOVASI TEKNOLOGI PENINGKATAN SENTRA INDUSTRI PANDE BESI
Authors: Kristanti Bella Arum , Wakidah Riska Nur , Muktiningrum Trinil
Published: January 2025

Economic development is essential for enhancing community welfare, particularly in Kiping Village, Tulungagung Regency, East Java, where the majority of residents rely on blacksmithing. This traditional industry primarily produces agricultural tools like knives, sickles, and machetes using simple and conventional methods. However, the quality of these products often falls short in a competitive market increasingly dominated by manufactured alternatives.
To revitalize the Blacksmith Small and Medium Industry (IKM) in Kiping, it is crucial to adopt a Smart Economy strategy that emphasizes entrepreneurship and innovation. Implementing modern techniques, such as automatic electroplating chrome technology, can significantly improve product quality, durability, and aesthetic appeal. This enhancement will not only help local blacksmiths compete with mass-produced items but also increase the perceived value of their products.
Moreover, the current marketing practices, which rely heavily on collectors, limit the artisans' reach and profit margins. By integrating digital marketing strategies, blacksmiths can directly connect with consumers, expanding their market and securing better prices for their goods. This shift towards a more sustainable and resilient business model will empower local craftsmen, ensuring that they receive fair compensation for their work.
Ultimately, fostering innovation and improving marketing strategies will not only enhance the competitiveness of Kiping’s blacksmiths but also contribute to the broader goal of local economic development, uplifting the community and securing a sustainable livelihood for its residents.
EDUKASI HUKUM TENTANG PEMAHAMAN USIA PERKAWINAN DI MTS ALKHAIRAAT PARIGI
Authors: Irzha Friskanov. S  , Dewi Kemala Sari
Published: January 2025

Fenomena perkawinan dini bukan menjadi hal yang baru di Indonesia. Dalam perkembangannya, lahirlah Undang-Undang Nomor 16 Tahun 2019,  artinya negara konsen pada hak dan kewajiban anak. Tak dipungkiri, masih ada celahnya masyarakat melakukan perkawinan di bawah usia perkawinan dengan menggunakan dispensasi nikah yang diajukan di pengadilan. Perubahan batas usia perkawinan ini merupakan langkah yang dilakukan pemerintah untuk menekan tingginya pernikahan dini, akan tetapi aturan ini ternyata tidak memberikan dampak signifikan disebabkan karena masih adanya dispensasi perkawinan yang diberikan kepada calon mempelai yang akan menikah di bawah usia 19 tahun dengan catatan ada izin dari orang tua dan diajukan permohonan dispensasi perkawinan di pengadilan. Kegiatan pengabdian ini akan dilakukan di MTS Alkhairat Parigi dengan target peserta siswa kelas X dan XI dengan metode pelaksanaan ceramah dan diskusi kemudian dilanjutkan dengan pendampingan. Perkawinan anak memiliki dampak negatif yang signifikan terhadap kesehatan, pendidikan, ekonomi, dan psikologis anak-anak. Secara kesehatan, anak perempuan berisiko mengalami komplikasi kehamilan dan masalah kesehatan reproduksi. Dari sisi pendidikan, mereka cenderung putus sekolah, membatasi kesempatan kerja, dan menyebabkan ketergantungan finansial. Psikologis, mereka menghadapi tekanan emosional, risiko kekerasan dalam rumah tangga, dan hambatan perkembangan sosial. Selain itu, perkawinan anak melanggar hak asasi manusia, termasuk hak atas pendidikan dan perlindungan dari kekerasan. Oleh karena itu, diperlukan upaya bersama dari berbagai pihak untuk mengakhiri praktik ini dan melindungi hak serta masa depan anak-anak.
IMPLEMENTASI STRATEGI PEMASARAN MELALUI WEBSITE DENGAN METODE SWOT SEBAGAI UPAYA PENINGKATAN PENJUALAN
Authors: Putri Anisa Meliantika , Manafe Leonard Adrie , Wahyudi Agus
Published: January 2025

Penelitian ini dilakukan dengan tujuan untuk mengetahui peningkatan penjualan dengan strategi pemasaran melalui website pada PT. Roda Hammerindo Jaya (RHJ). Penelitian ini diteliti dengan berdasarkan teknologi internet yang semakin maju pada saat ini. Penulis dalam menganalisis penelitian ini metode pendekatan yang digunakan yaitu pendekatan kualitatif dengan analisis deskriptif. Untuk mengukur kekuatan, kelemahan, peluang dan ancaman yakni digunakan metode analisis SWOT (Strenghts, Weaknesses, Opportunities, Threats). Teknik data yang dikumpulkan oleh peneliti yakni melalui wawancara, observasi dan juga dokumentasi. Penelitian yang dihasilkan ialah kekuatan yang dimiliki RHJ yaitu harga yang kompetitif dengan menawarkan produk yang bervariasi. Terdapat kelemahan yang dimiliki yaitu sering terjadinya stok barang yang kosong. Peluang yang dimiliki RHJ adanya penjualan melalui website menjadi salah satu cara untuk menjangkau konsumen secara luas dan untuk meningkatkan volume penjualan. Ancaman yang sedang dihadapi saat ini banyak pesaing bisnis yang menjual produk serupa. Sehingga dapat digambarkan bahwa strategi pemasaran online melalui website yang dilakukan RHJ mempunyai kekuatan dan peluang yang bisa digunakan dengan maksimal dalam mempromosikan produk secara online.
Analisis Pemasaran Syariah Pembiayaan Cicil Emas Bank Syariah Indonesia KCP Bangkalan Trunojoyo
Authors: Ahmad Muharram Alafi  , Trischa Relanda Putra
Published: January 2025

Penelitian ini bertujuan untuk mengidentifikasi strategi pemasaran yang diterapkan oleh Bank Syariah Indonesia KCP Bangkalan Trunojoyo dalam memasarkan produk pembiayaan cicil emas serta untuk meningkatkan jumlah nasabah produk tersebut. Penelitian ini menggunakan pendekatan deskriptif kualitatif, dengan data diproses menggunakan perangkat lunak Nvivo dan dianalisis melalui metode reduksi. Hasil penelitian mengungkap bahwa Bank Syariah Indonesia KCP Bangkalan Trunojoyo telah berhasil mengadopsi konsep Marketing Mix 4C dalam strategi pemasarannya. Bank juga telah menemukan variabel yang memengaruhi pilihan konsumen untuk produk pembiayaan cicil emas. Ini termasuk preferensi budaya, sosial, ekonomi, dan psikologis yang memengaruhi keputusan pembelian mereka.  Hal ini menunjukkan bahwa memahami kebutuhan dan keinginan pelanggan dengan pendekatan yang komprehensif dan terorganisir sangat penting untuk keberhasilan pemasaran produk syariah.
Comparative Analysis of the Effect of Sex and Age on the Hematological and Biochemical Profile of BALB/c and C57BL/6 Inbred Mice
Authors: Patel Suresh , Patel Satish , Kotadiya Ashvin , Patel Samir , Shrimali Bhavesh , Tank Mihir , Patel Tushar , Trivedi Harshida , Kshirsagar Samadhan , Jain Mukul
Published: January 2025

Mice are the most commonly used models of infectious disease, and disease in mice is similar to that of humans. As a consequence, standard hematology and biochemistry reference values in mice are essential to evaluate functional changes caused by experimental treatments, although very few data in the literature provide a comparative reference range. The aim of this investigation was to establish the reference intervals for major hematology and biochemistry analytes in 2 inbred mouse strains, BALB/c and C57BL/6, at 3 different age ranges. Parameters were assessed in 600 mice (300 male and 300 female) of BALB/c and C57BL/6 strains at 6 to 8 wk, 10 to 14 wk, and 6 to 9 mo of age. Reference intervals were calculated by nonparametric or robust methods according to sample size, and statistical analyses were performed to assess the changes in relation to sex, age, and strain. The data demonstrate that strain, sex, and age have significant effects on the hematologic and biochemical profiles of mice. Hemoglobin, Hct, MCH, MCHC, neutrophils, eosinophils, and ALP were found to be significantly greater in BALB/c mice. In contrast, WBC, lymphocytes, basophils, glucose, total protein, albumin, and urea were found to be significantly greater in C57BL/6 mice in all age ranges. Lymphocytes and ALP progressively decreased with age, while neutrophils increased with age in both strains. The study successfully defined and established reference intervals for hematologic and biochemical analytes in 2 inbred mouse strains at 3 different age ranges. The reference values reported here could be useful in characterizing the phenotype of experimental mice and assessing the changes caused by investigational treatments.
An Overview of Anesthetic Procedures for Ferret (Mustela putorius furo) Preclinical Brain MRI: A Call for Standardization
Authors: Celdran-Bonafonte Diego , O’Connell Kathryn A , Dieckhaus Laurel , Mocarski Emily , Adras Natalie M , Hutchinson Elisabeth B , Pacharinsak Cholawat
Published: January 2025

Neuroscience research has been increasingly active during the last 2 decades, largely driven by the high prevalence and increasing burden of neurologic disorders. While rodents are essential models for biomedical research of neurologic disorders, they lack similar brain anatomy and protein expression profiles to humans, thus limiting their translational value as models of traumatic brain injury, stroke, Alzheimer’s disease, and Parkinson’s disease. The use of ferrets as a model species in neuroscience has been increasing due to their neuroanatomical similarities with humans, including a gyrencephalic brain and larger white matter-to-gray matter ratio. Compared with nonhuman primates, sheep, and swine, ferrets also have the advantages of reduced size, lower housing costs, and lower phylogenetic order. These, among other advantages, make ferrets a promising species to bridge research gaps and complement traditional rodent studies. Although modern neuroscience research in ferrets relies heavily on advanced imaging techniques such as magnetic resonance imaging (MRI), most of the preclinical MRI installations are not designed or optimized for use with ferrets. In this paper we discuss the intricacies and limitations that need to be considered when performing ferret MRI procedures. Reviews of ferret biologic peculiarities, anesthetic protocols, management of complications, and the impact of these factors on MRI outcomes are presented. Standardizing anesthesia protocols for the conduct of MRI in ferrets will aid in better physiologic monitoring as well as imaging outcomes that ultimately benefit the science being conducted.
Effective Eradication of Mouse Norovirus and Helicobacter spp. in Laboratory Mice (Mus musculus) via Iodine Immersion and Cross-Fostering Technique
Authors: Kehoe Roseann E , Reimer David C , Bright Lauren A , Singh Bhupinder , Eswaraka Jeetendra
Published: January 2025

Eradication of pathogens from mouse colonies is crucial for scientific research reproducibility and animal welfare. The previously described techniques for eradicating pathogens by rederivation through embryo transfer or caesarian technique can be costly and technically challenging. The objective of our study was to assess the efficacy of iodine immersion combined with cross-fostering for eradicating murine norovirus (MNV) and Helicobacter spp. in laboratory mice. The iodine immersion technique was modified to prevent pathogen transmission and reduce the risk of cannibalism. The hypothesis of this study was that iodine immersion combined with cross-fostering of pups would be as effective at eliminating MNV as it is at clearing Helicobacter in laboratory mice. This study was performed on newborn litters of various mice strains housed in a room positive for both these pathogens. The pups were immersed in warmed, diluted iodine within 48 h of birth, and then cross-fostered to a Swiss Webster dam negative for MNV and Helicobacter. The presence of MNV and Helicobacter in donor dams, weanlings, and adult post-immersion animals was tested using fecal PCR. All 27 litters born to MNV- and Helicobacter-positive dams tested negative for both pathogens at weaning and at 8 wk postweaning. Follow-up PCR exhaust dust testing from the housing racks confirmed a negative status for MNV and Helicobacter over multiple quarterly pathogen screening tests conducted over an 18-mo period. This study is, to our knowledge, the first to demonstrate successful eradication of MNV through iodine immersion combined with cross-fostering, proving this method to be effective for eliminating MNV and Helicobacter spp. in affected colonies.
Evaluating Outcomes of Diazepam Administration in Gradual Steps Introductions of Adult Male and Female Rhesus Macaques (Macaca mulatta)
Authors: Myers Adam K , Baker Kate C , Kubisch Michelle J , Russell-Lodrigue Kasi E , Bohm Rudolf P
Published: January 2025

Social housing remains one of the best forms of environmental enhancement for nonhuman primates (NHPs). The gradual steps (GS) method, a 2-step plan involving an initial phase of limited physical contact (protected contact [PC]) prior to full contact (FC), is widely used for introducing macaque pairs. Recent evidence has suggested that administration of diazepam prior to FC introduction, without a PC phase, improves the success rate of pairings among adult male rhesus macaques (Macaca mulatta). Nevertheless, given the popularity of the standard GS method, there is considerable interest in using diazepam along with this technique. We hypothesized that administering a single dose of diazepam prior to the PC phase would improve the success rates of isosexual pairings of unfamiliar adult macaques. Twelve males and 12 females were studied in each of 3 groups, with 2 different doses of oral diazepam (2.5 or 3.2 mg/kg) and controls introduced without diazepam. Pairs were deemed successful after 14 consecutive days of compatible FC housing. Among males, success rates for the low diazepam, high diazepam, and control groups were 67%, 50%, and 67%, respectively. Among females, the corresponding values were 50%, 33%, and 17%. There were no significant differences in overall introduction success rates for either sex. However, among females, the success rates during the initial PC phase were significantly higher in introductions involving the lower dose of diazepam (83%) than among controls (33%). Descriptively, in both sexes, less severe wounding patterns were observed with the lower dose compared with either the high dose or control groups. Our results suggest that diazepam administration prior to the PC phase of the GS method does not improve pairing outcomes for either sex in rhesus macaques. However, diazepam may have some utility in moderating wounding during unsuccessful introductions.
The Impact of Athymic Nude Mouse Stock and Colony Source on the Severity of Corynebacterium-Associated Hyperkeratosis
Authors: Michelson Abigail , Cheleuitte-Nieves Christopher , Miranda Ileana C , Ricart Arbona Rodolfo , Dobtsis Irina , Wipf Juliette , Lipman Neil S
Published: January 2025

Corynebacterium bovis (Cb), the etiologic agent of Corynebacterium-associated hyperkeratosis (CAH) in nude mice, may impact research outcomes. Little is known about the differences in the course and severity of CAH in different outbred athymic nude mice stocks. Three genetic stocks (designated A, B, and C), 1 of which was obtained from 2 geographically separate colonies with distinct microbiota (A1 and A2), were inoculated topically with 1 × 108 cfu of a pathogenic Cb field isolate (no. 7894; n = 6/stock) or sterile media (n = 2/stock; controls). Clinical signs were assessed daily and scored 0 to 5 based on lesion severity. Mice were euthanized at 14 (A1, A2, B, and C) or 28 (B) days postinoculation (dpi), macroscopic changes were documented, and 6 skin samples per mouse were obtained and histologically scored 0 to 4 based on the presence and severity of hyperkeratosis, acanthosis, inflammation, and bacterial colonies. No stock A1 or control mice developed clinical disease; 1 of 6 stock B mice developed mild CAH (mean peak clinical score [MPCS]: 0.33) at 14 dpi (14-d group); 2 of 6 stock B (28-d group) developed mild CAH at 15 dpi (MPCS: 0.33); and all stock C and A2 mice developed significant clinical signs at 5 dpi (MPCS: 2.5 and 3, respectively), which resolved by 11 dpi. Despite differences in clinical presentation, all Cb-infected mice had hyperkeratosis and/or acanthosis with associated bacterial colonies. Stocks A1 and B, which had minimal or no clinical signs, were colonized with Corynebacterium amycolatum (Ca). In contrast, stocks C and A2 were not colonized with Ca, raising the possibility that Ca and/or other components of the skin microbiota may mitigate clinical signs but not necessarily all histopathologic changes associated with infection. These findings suggest host genetics and/or the skin microbiota can markedly influence the presentation of CAH in nude mice.
Light Cycle Phase Effects on Behavioral Responses to Stress Exposure in Rats
Authors: Brown Chad E , Borrell Andrew C , DeMar James C , Almarode Cooper J , Naderi Aurian O , Han Abraham J , Taylor Rachel M , Lowery-Gionta Emily G
Published: January 2025

Animal models enable investigation of the impact of stress on emotional-behavioral performance to facilitate understanding of posttraumatic stress symptoms experienced in humans. Refinement of animal stress models could lead to a reduction in the number of subjects needed to detect statistically significant stress effects, in accordance with Russel and Burch’s three Rs of research. We assessed whether performance of experimental procedures (that is, stress exposure and poststress behavioral testing) during the dark or light phases of the 12-h light/12 h-dark cycle is a refinement that could accomplish this reduction. At 3 h into either the light or dark phase, male and female adult Sprague–Dawley rats underwent a single-day traumatic stress exposure. Rats then underwent behavioral testing for exploratory behaviors, startle responses, and conditioned fear responses at 2 h, 1 d, and 9 d after stress exposure. Distance traveled in the elevated plus maze (EPM) by both male and female rats was significantly reduced in the dark phase compared with the light phase. Male rats of the dark phase group also spent less time in the open arms of the EPM, and traveled less, spent less time in the center, and spent more cumulative time freezing in the open field. Female rats of the dark phase group spent more cumulative time freezing in the EPM and exhibited significantly more tone-cued conditioned freezing responses. Our results suggest that performing experimental procedures during the dark phase of the light cycle may be a useful refinement mechanism, as procedures performed during this period had the greatest effect on behavioral outcomes in both males and females. Light cycle phase is an experimental variable that should be considered when designing experiments to maximize behavioral effects, including those in response to stress.
Antidiabetic Effects and Mechanisms of Action of Uncaria gambir Roxb. in Diabetic Sprague–Dawley Rats
Authors: Fajarwati Indah , Solihin Dedy D , Wresdiyati Tutik , Batubara Irmanida , Mariya Sela S
Published: January 2025

The antidiabetic properties of Uncaria gambir are not yet fully understood, particularly concerning how it affects diabetic animal models. Further investigation in this aspect is pivotal before initiating clinical evaluations. This study aimed to investigate the antidiabetic activity of U. gambir and how it influences blood glucose levels in diabetic Sprague–Dawley rats. In this study, 28 rats were divided into 7 groups. The groups were as follows: a nondiabetic rat group, a nondiabetic rat group given U. gambir, a diabetic rat group, a diabetic rat group given glibenclamide, and 3 diabetic rat groups given U. gambir at 3 doses (200, 300, and 400 mg/kg). Diabetes was induced using streptozotocin (50 mg/kg) given by intraperitoneal injection. Blood glucose levels were measured weekly, and the animals were euthanized at the end of the experiment. Intracardiac blood and tissues such as the pancreas, liver, and skeletal muscle were collected for further analysis. The results showed that administering U. gambir to diabetic rats resulted in significantly lower blood glucose levels than untreated diabetic rats. U. gambir has a complex mechanism to reduce blood glucose levels. including increase of insulin production, preservation of the islets and pancreatic β cells, and optimization of glycogenesis, as reflected in a significant increase in liver glycogen levels. These findings suggest that U. gambir’s multicompound and multitarget capabilities in controlling blood glucose levels may have utility for treatment of diabetes.
Peningkatan Pemahaman Urgensi Peristiwa Qurban Melalui Khutbah dan Imam di Hari Raya Idul Adha di Masjid Nurul Wathon, Kelurahan Lubuk Tukko Baru, Tapanuli Tengah
Authors: Siregar Saputra Husein
Published: January 2025

Kegiatan pengabdian masyarakat ini dilaksanakan melalui peran sebagai khatib dan imam pada Hari Raya Idul Adha dengan tema khutbah "Ekspresi Iman dan Cinta di Keluarga Ibrahim." Khutbah ini bertujuan untuk mengajak jamaah merefleksikan kisah keluarga Nabi Ibrahim AS yang penuh dengan nilai-nilai ketakwaan, pengorbanan, dan cinta. Dalam khutbah, ditekankan pentingnya menanamkan iman dan cinta dalam keluarga, sebagaimana ditunjukkan oleh Nabi Ibrahim AS, Hajar, dan Ismail AS. Kegiatan ini mendapat respons positif dari jamaah yang merasa terinspirasi untuk memperkuat hubungan keluarga dengan dasar iman yang kokoh. Selain khutbah, kegiatan juga meliputi pelaksanaan salat Idul Adha dan penyembelihan hewan qurban. Kegiatan ini berhasil meningkatkan kesadaran jamaah akan pentingnya memperkuat nilai-nilai spiritual dalam keluarga, menjadikan keluarga sebagai fondasi utama untuk menghadapi tantangan kehidupan modern dengan berlandaskan iman dan cinta.
Pendampingan Penggunaan Media Pembelajaran Mind Mapping sebagai Solusi Mengatasi Kebosanan Siswa dalam Pembelajaran Sejarah Kebudayaan Islam (SKI) di Min 2 Kepulauan Sangihe
Authors: Darise Gina Nurvina , Mahmudah Nurul , Kusnan Kusnan , Saud Indah Wardaty , Jafar Gita Fajrin , Mokodompit Nurul Fajriani , Alkatiri Rahmawaty
Published: January 2025

Sejarah Kebudayaan Islam (SKI) merupakan mata pelajaran yang wajib diajarkan di berbagai jenjang madrasah. Namun, hingga saat ini, pembelajaran Sejarah Kebudayaan Islam (SKI) masih dianggap sebagai pelajaran yang membosankan. Untuk mengatasi hal tersebut, tim pengabdian yang terdiri dari dosen Fakultas Tarbiyah dan Ilmu Keguruan IAIN Manado berinisiatif melakukan pendampingan dengan menggunakan media pembelajaran mind mapping (peta pikiran). Metode Participatory Action Research (PAR) digunakan dalam pelaksanaan program ini untuk memastikan bahwa pendekatan yang diterapkan relevan dengan kebutuhan siswa dan efektif dalam meningkatkan keterlibatan serta pemahaman mereka terhadap materi pelajaran. Lokasi pengabdian bertempat di MIN 2 Kepulauan Sangihe, Provinsi Sulawesi Utara. Kegiatan pengabdian ini mendapatkan respons positif, yang ditunjukkan oleh siswa dan guru. Hasilnya menunjukkan bahwa mind mapping tidak hanya membantu siswa memahami dan mengingat materi dengan lebih mudah, tetapi juga memberikan dampak positif pada proses pengajaran guru, khususnya pada mata pelajaran Sejarah Kebudayaan Islam (SKI).
Peran Ganda Wanita dalam Ketahanan Ekonomi Keluarga: Studi Kasus pada Wanita Pengemudi Ojek Suru-Suru All Delivery di Kabupaten Mandailing Natal
Authors: Setiadi Fadlan Masykura , Rahman Aulia
Published: January 2025

Penelitian ini membahas pemberdayaan wanita dalam sektor informal, dengan fokus pada pengemudi ojek Suru-Suru All Delivery di Mandailing Natal yang menjalankan peran ganda sebagai ibu rumah tangga dan pencari nafkah. Studi ini bertujuan untuk mengeksplorasi pengelolaan peran ganda tersebut, dampaknya terhadap ketahanan ekonomi keluarga, serta tantangan yang dihadapi. Penelitian kualitatif ini menggunakan metode studi kasus dengan wawancara mendalam, observasi partisipatif, dan dokumentasi pada lima partisipan. Hasil menunjukkan bahwa pekerjaan ini berkontribusi signifikan terhadap pemenuhan kebutuhan dasar, pendidikan anak, dan tabungan keluarga, meskipun terdapat tantangan seperti kelelahan fisik, stigma sosial, dan masalah keamanan. Penelitian ini menawarkan perspektif baru dengan mengkaji pengalaman wanita di sektor transportasi daring di daerah pedesaan yang kurang dieksplor oleh studi sebelumnya. Hasil ini memberikan rekomendasi bagi pengambil kebijakan untuk menciptakan peluang kerja inklusif yang mendukung pemberdayaan ekonomi wanita di daerah pinggiran.
Sosialisasi Bijak Menggunakan Gadget terhadap Anak di Panti Asuhan Al-Ummah Ponorogo
Authors: Litanianda Yovi , Nuryadin Ridho Akbar , Reza Muhammad
Published: January 2025

Penggunaan gadget dalam kalangan anak-anak menjadi fokus penting dalam berbagai lembaga sosial, terutama di Panti Asuhan Al-Ummah. Gadget menjadi bagian tak terpisahkan dari kehidupan modern, membawa manfaat besar sekaligus dampak yang perlu dipertimbangkan, terutama dalam hal penggunaan berlebihan. Oleh karena itu, kegiatan pengabdian ini bertujuan untuk melakukan sosialisasi bijak menggunakan gadget kepada 26 anak di panti dengan rentang usia 5 hingga 16 tahun. Melalui observasi lapangan, dokumentasi, Pre-test, dan Post-test, hasil observasi menunjukkan bahwa 80,77% atau setara 21 anak panti menggunakan gadget lebih dari 2 jam. Berdasarkan Pre-test ditemukan tingkat pemahaman anak-anak mengenai penggunaan gadget yang aman berada pada nilai rata-rata 45 artinya untuk pemahaman bijak menggunakan gadget masih kurang paham. Kegiatan ini secara komprehensif mensosialisasikan penggunaan gadget kepada anak Panti Asuhan Al-Ummah selama 2 jam 30 menit. Setelah sosialisasi, Post-test menunjukkan peningkatan rata-rata nilai menjadi 72,3, menggambarkan efektivitas program sosialisasi dalam meningkatkan pemahaman dan perilaku bijak menggunakan gadget. Peningkatan signifikan pada nilai Post-test mencerminkan dampak positif dari sosialisasi, menunjukkan bahwa anak-anak mampu meningkatkan pemahaman dan perilaku bijak menggunakan gadget. Simpulan penelitian ini menegaskan bahwa program sosialisasi bijak menggunakan gadget berhasil meningkatkan kesadaran dan pemahaman anak-anak terkait risiko penggunaan gadget berlebihan, dengan peningkatan rata-rata sebesar 27,3 poin.
Strategi Tiktok Live Streaming dan Celebrity Endorser dalam Meningkatkan Keputusan Pembelian Produk Erigo
Authors: Amran Ali , Rahmadi Egi , Dewi Sri W K
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh live streaming dan celebrity endorser dalam keputusan pembelian produk Erigo pada aplikasi tiktok. Data dikumpulkan dengan melakukan survei menggunakan kuesioner kepada 100 pengguna tiktok yang berdomisili di Kota Bandung dan ditentukan dengan teknik purposive sampling. Alat analisis data menggunakan SPSS. Hasil penelitian menunjukkan live streaming secara parsial tidak berpengaruh terhadap keputusan pembelian, celebrity endorser secara parsial berpengaruh terhadap keputusan pembelian, dan terdapat pengaruh positif secara simultan antara live streaming dan celebrity endorser terhadap keputusan pembelian. Manfaat penelitian ini yaitu untuk mengetahui dan menganalisis cara tepat untuk menerapkan strategi pemasaran yang dilakukan perusahaan melalui live streaming dan celebrity endorser pada media sosial.
PENGARUH CONTENT MARKETING TERHADAP CUSTOMER ENGAGEMENT PADA INSTAGRAM MUMS GARDEN
Authors: Nurcahyani Dwi , Fitria Dona
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh content marketing yang terdiri dari reader cognition, sharing motivation, persuasion, decision making, dan life factor terhadap customer engagement pada Instagram Mums Garden. Populasi penelitian ini adalah followers atau pengikut Instagram Mums Garden dengan jumlaha 1.464 pengikut. Metode penelitian yang digunakan adalah kuantitatif dengan jumlah sampel sebanyak 100 responden. Data yang dikumpulkana melalaui kuesioner, observasi, dan dokumentasi. Analisis data dilakukan menggunakan regresi linear berganda. Pengaruh ini terlihat dari bentuk persamaan regresi yang dihasilkan dalam penelitian adalah Y = 5,875 + 0,569 X1+ 0,256 X2 + 0,709 X3 + 0,719 X4 + 0,404 X5. Koefisien determinasi menunjukan bahwa content marketing berpengaruh terhadap customer engagement sebesar 81% sedangkan sisanya 19 dipengaruhi oleh faktor lain. Darai hasil uji F dan uji t membuktikan bahwa content marketing yang terdiri dari reader cognition, sharing motivation, persuasion, decision making, dan life factor secara silmutan dan parsial berpengaruh terhadap customer engagement pada Instagram Mums Garden.Kata Kunci: Content Marketing; Customer Engagement.
THE INFLUENCE OF SERVICE QUALITY, FOOD QUALITY AND PERCEIVED VALUE ON CUSTOMER SATISFACTION IN PADANG PAYAKUMBUAH
Authors: Aqilah Khonsa Mumtaz , Aini Husna N , Nuh Ahmad , Eddy W Finantyo
Published: January 2025

The research titled "The Impact of Service Quality, Food Quality, and Perceived Value on Customer Satisfaction at Padang Payakumbuah" focuses on identifying key factors that influence customer satisfaction in the culinary sector, specifically at the BSD branch of Padang Payakumbuah in Tangerang Selatan. Utilizing online questionnaires distributed to customers who dined there in the last three months, the study aims to uncover significant relationships between service quality, food quality, and perceived value. It is anticipated that higher service and food quality will enhance perceived value, leading to increased customer satisfaction. Ultimately, the findings are intended to provide actionable insights for restaurant management to improve service delivery and food offerings, thereby fostering brand loyalty and maintaining Padang Payakumbuah's reputation in the competitive market for traditional Minangkabau cuisine(Dewi et al., 2023).
Bayesian Diagnostic Classification Models for a Partially Known Q-Matrix
Authors: Yamaguchi Kazuhiro
Published: January 2025

This study proposes a Bayesian method for diagnostic classification models (DCMs) for a partially known Q-matrix setting between exploratory and confirmatory DCMs. This Q-matrix setting is practical and useful because test experts have pre-knowledge of the Q-matrix but cannot readily specify it completely. The proposed method employs priors for the Bayesian variable selection to simultaneously estimate the effects of active and nonactive attributes, and the simulations lead to appropriate attribute recovery rates. Furthermore, the proposed method recovers the attribute mastery of individuals at the same as for a fully known Q-matrix. In addition, the proposed methods can be used to estimate the unknown Q-matrix part. A real data example indicates that the proposed Bayesian estimation method for the partially known Q-matrix fits better than a fully specified Q-matrix. Finally, extensions and future research directions are discussed.
Caracterización morfológica y anatómica del fruto, semilla y plántula de Schinopsis marginata Engl. (Anacardiaceae) y su relación con las fases de la germinación
Authors: Herrera Álvarez Ana Belén , Agüero César Germán , Joseau Jacqueline , Molinelli María Laura
Published: January 2025

Schinopsis marginata Engl. (Anacardiaceae) is a dominant native tree of the Chaco Serrano Forest of Argentina. The objectives were to characterize the morphology and anatomy of the fruit, seed and seedling, describe the morphology of the seedling in the nursery and establish relationships with the germination: water uptake and radicle emission. Microscopy, laboratory and nursery germination, and staining techniques were applied for anatomical, morphological and water uptake characterization. The definition of the fruit as samara is based on morphology and anatomy, and new data on the pericarp and its function as a mechanical barrier during root emergence are provided. The morphology and anatomy of the seed is characterized for the first time with the novelty of the vestigial aril. In the embryo, the storage function of the cotyledons is verified. The morphology of the nursery seedling was confirmed and diagnostic characters were established for its recognition. In relation to the germination, the path taken by the water is determined and it is verified that the macrosclereids of the mesocarp constitute the physical barrier to water uptake. The function of the aril in the opening of the endocarp in the imbibition phase is suggested, which favors root emergence.
BOUNDLESS CREATION, VIRTUAL MUSIC AND GLOBAL COLLABORATION
Authors: Justin Rizky Stephanie , Darmayuda I Komang
Published: January 2025

The advent of digital technologies has revolutionized the way music is created, shared, and experienced, thereby enabling a new era of boundless creation through virtual music. This study explores how the convergence of digital tools, virtual platforms, and global connectivity has transformed the landscape of music production, fostering unprecedented opportunities for collaboration across borders, cultures, and genres. Musicians, producers, and composers can now create, record, and perform together in virtual spaces regardless of their physical location. By leveraging cloud-based software, real-time collaboration tools, and virtual instruments, creators are no longer limited by geographical constraints, allowing for more diverse, innovative, and experimental work. The study also examines the impact of virtual music on the global music industry, including its role in democratizing access to music production, expanding audience reach, and reshaping traditional models of distribution and performance. Ultimately, the fusion of virtual music and global collaboration has opened new avenues for artistic expression, cross- cultural exchange, and creative freedom.
TOPENG RANGDA AS METAPHOR OF DEWI DURGA BY TJOKORDA OKA TUBLEN
Authors: Artawan Cokorda Alit , Mudra I Wayan , Muka I Ketut , Karja I Wayan
Published: January 2025

The Topeng Rangda created by Tjokorda Oka Tublen with a distinctive character as an interpretation of Durga has a magical impression. This research aims to deeply understand Rangda as a metaphor of Durga by Tjokorda Oka Tublen. The Topeng Rangda created by Tjokorda Oka Tublen's is sacred to the community and used as a role model by the Balinese people.  Nevertheless, until now there has been no special study about it. This research uses a qualitative method. The data collection is done by purpose sampling with observation, interview, and literature study techniques, dissected with aesthetic theory and metaphor theory. The result of this study, Topeng Rangda as a metaphor is a mask with a scary face as the embodiment of Dewi Durga in white with buck teeth, bulging eyes with a magical, majestic and authoritative impression. The process of creating Tjokorda Oka Tublen's mask includes: newasen, nyawi, nyalonan, makalan, nadiang, nelesang, ngalusang, ngewarna, dan pasupati.