bluuebunny/crossref_metadata_2025 huggingface dataset:
Sufficient Condition for Estimation in DesigningH∞Filter-Based SLAM
Authors: Othman Nur Aqilah , Ahmad Hamzah , Namerikawa Toru
Published: February 2015

Extended Kalman filter (EKF) is often employed in determining the position of mobile robot and landmarks in simultaneous localization and mapping (SLAM). Nonetheless, there are some disadvantages of using EKF, namely, the requirement of Gaussian distribution for the state and noises, as well as the fact that it requires the smallest possible initial state covariance. This has led researchers to find alternative ways to mitigate the aforementioned shortcomings. Therefore, this study is conducted to propose an alternative technique by implementingH∞filter in SLAM instead of EKF. In implementingH∞filter in SLAM, the parameters of the filter especiallyγneed to be properly defined to prevent finite escape time problem. Hence, this study proposes a sufficient condition for the estimation purposes. Two distinct cases of initial state covariance are analysed considering an indoor environment to ensure the best solution for SLAM problem exists along with considerations of process and measurement noises statistical behaviour. If the prescribed conditions are not satisfied, then the estimation would exhibit unbounded uncertainties and consequently results in erroneous inference about the robot and landmarks estimation. The simulation results have shown the reliability and consistency as suggested by the theoretical analysis and our previous findings.
A New Energy Efficient and Reliable MedRadio Scheme Based on Cooperative Communication for Implanted Medical Devices
Authors: Hsu Jen-Ming , Chiang Tzu-Chiang , Yu Yao-Chang , Teng Wei-Guang , Hou Ting-Wei
Published: February 2015

The most significant shortcoming of implanted devices is the battery life. With advanced technology, implanted devices can have the capability to communicate with other health-related devices, but this also means the energy consumption requirement is greater than ever. Less power consumption would extend the duration of the batteries of implanted medical devices. In this paper, an energy efficient and reliable communication service device scheme that does not require any modification to the existing wireless network structure or the implanted devices under consideration is proposed. The scheme is intended to save a target device's energy necessary for resending communication signals by introducing a neighbor group header node and cooperative (wearable) nodes. The simulation results show that the scheme would result in energy savings of 70 percent with one or two cooperative nodes as compared with the current best approach.
A Bayesian Approach for Localization of Acoustic Emission Source in Plate-Like Structures
Authors: Yan Gang , Tang Jianfei
Published: February 2015

This paper presents a Bayesian approach for localizing acoustic emission (AE) source in plate-like structures with consideration of uncertainties from modeling error and measurement noise. A PZT sensor network is deployed to monitor and acquire AE wave signals released by possible damage. By using continuous wavelet transform (CWT), the time-of-flight (TOF) information of the AE wave signals is extracted and measured. With a theoretical TOF model, a Bayesian parameter identification procedure is developed to obtain the AE source location and the wave velocity at a specific frequency simultaneously and meanwhile quantify their uncertainties. It is based on Bayes’ theorem that the posterior distributions of the parameters about the AE source location and the wave velocity are obtained by relating their priors and the likelihood of the measured time difference data. A Markov chain Monte Carlo (MCMC) algorithm is employed to draw samples to approximate the posteriors. Also, a data fusion scheme is performed to fuse results identified at multiple frequencies to increase accuracy and reduce uncertainty of the final localization results. Experimental studies on a stiffened aluminum panel with simulated AE events by pensile lead breaks (PLBs) are conducted to validate the proposed Bayesian AE source localization approach.
A Yaw Stability Control Algorithm for Four-Wheel Independently Actuated Electric Ground Vehicles considering Control Boundaries
Authors: Lin Cheng , Xu Zhifeng , Zhang Ru
Published: February 2015

A hierarchical control algorithm of direct yaw moment control for four-wheel independently actuated (FWIA) electric ground vehicles is presented. Sliding mode control is adopted to yield the desired yaw moment in the higher layer of the algorithm due to the possible modeling inaccuracies and parametric uncertainties. The conditional integrator approach is employed to overcome the chattering issue, which enables a smooth transition to a proportional + integral-like controller, with antiwindup, when the system is entering the boundary layer. The lower level of the algorithm is given to allocate the desired yaw moment to four wheels by means of slip ratio distribution and control for a better grasp of control boundaries. Simulation results, obtained with a vehicle dynamics simulator, Carsim, and the Matlab/Simulink, show the effectiveness of the control algorithm.
Ethnic-Specific Genetic Association of Variants in the Corticotropin-Releasing Hormone Receptor 1 Gene with Nicotine Dependence
Authors: Tang Xiujun , Zhan Shumin , Yang Liping , Cui Wenyan , Ma Jennie Z. , Payne Thomas J. , Li Ming D.
Published: February 2015

Twin and family studies indicate that smoking addiction is highly influenced by genetic factors. Variants in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression. In this study, we tested five single nucleotide polymorphisms (SNPs) inCRHR1for their association with ND, which was assessed by smoking quantity (SQ), the Heaviness of Smoking Index (HSI), and the Fagerström test for ND (FTND) in 2,037 subjects from 602 families of either European American (EA) or African American (AA) ancestry. Association analysis of the five SNPs revealed a significant association of rs171440 with SQ in the AA sample and with SQ and FTND in the pooled AA and EA samples. Haplotype-based association analysis indicated significant association of haplotypes C-C (56.9%) and T-C (38.9%), formed by SNPs rs171440 and rs1396862, with SQ in the AA sample, C-C-G (47.6%) with SQ, and T-C-G (42.3%), formed by SNPs rs171440, rs1396862, and rs878886, with SQ and FTND in the pooled AA and EA samples. However, none of these associations remained significant after correction for multiple testing. Together, our results provide suggestive evidence for the involvement ofCRHR1in ND, which warrants further investigation using larger independent samples.
An Unusual Cause of Pulmonary Nodules in the Emergency Department
Authors: Yu Ryan , Ferri Melanie
Published: February 2015

We report a 51-year-old woman who presented to the emergency department with left-sided pleuritic chest pain 2 weeks after subtotal hysterectomy and bilateral salpingo-oophorectomy for a leiomyomatous uterus. Computed tomography scan of the chest revealed bilateral pulmonary nodules. Biopsy showed cytologically bland spindle cells without overt malignant features. Immunohistochemistry confirmed smooth muscle phenotype, in keeping with a clinicopathologic diagnosis of benign metastasizing leiomyoma (BML). BML does not frequently come to the attention of the emergency physician because it is rare and usually asymptomatic. When symptomatic, its clinical presentation depends on the site(s) of metastasis, number, and size of the smooth muscle tumors. Emergent presentations of BML are reviewed.
Xanthine Oxidase: Isolation, Assays of Activity, and Inhibition
Authors: Kostić Danijela A. , Dimitrijević Danica S. , Stojanović Gordana S. , Palić Ivan R. , Đorđević Aleksandra S. , Ickovski Jovana D.
Published: February 2015

Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Excessive production and/or inadequate excretion of uric acid results in hyperuricemia. This paper presents a detailed review of methods of isolation, determination of xanthine oxidase activity, and the effect of plant extracts and their constituents on it. Determining the content and activities of XO can be used for diagnostic purposes. Testing inhibition of XO is important for detection of potentially effective compounds or extracts that can be used to treat diseases that are caused by increased activity of XO.In vitrobioassays are used to examine test material for XO inhibition, as inhibitors of XO may be potentially useful for the treatment of gout or other XO induced diseases. Several authors reported on the XO inhibitory potential of traditionally used medicinal plants.
Green Synthesis and Characterization of Carbon Nanotubes/Polyaniline Nanocomposites
Authors: Nguyen Van Hoa , Shim Jae-Jin
Published: February 2015

Carbon nanotubes/polyaniline (CNT/PANI) nanocomposites were synthesized by the interfacial polymerization of aniline in the presence of CNTs using two green solvents, water and an ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate, [bmim][BF4]), as the two phases. The formation and incorporation of PANI on the surface of the CNTs were confirmed by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy ultraviolet-visible spectroscopy, and X-ray photoelectron spectroscopy. The analyses showed that the surface of the CNTs was coated with different morphologies of thin PANI layers depending on whether a HCl or HNO3solution was used. The thermal stability of the composites was much better than that of the bare CNTs and pure PANI. The as-prepared composites were also used to modify the nickel foam electrodes for characterization of the electrochemical properties.
An Analysis of Social Seed Network and Its Contribution to On-Farm Conservation of Crop Genetic Diversity in Nepal
Authors: Poudel Diwakar , Sthapit Bhuwon , Shrestha Pratap
Published: February 2015

Social seed systems are important for the maintenance of crop genetic diversity on farm. This is governed by local and informal system in the community through a farmers’ network. This paper analyses these local seed systems through application of social network analysis tools and mappings and examines the network member and its stability over space and time in a small rice farming community in Nepal. NetDraw software is used for data analysis and network mapping. We found that the dynamic network structure had key role in provisioning of traditional varieties and maintaining of crop genetic diversity on farm. We identify and ascertain the key network members, constituted either as nodal or bridging (connector) farmers, occupying central position in the network who promote seed flow of local crop diversity, thus strengthening crop genetic resource diversity on farm.
Assessment of Two School‐Based Programs to Prevent Universal Eating Disorders: Media Literacy and Theatre‐Based Methodology in Spanish Adolescent Boys and Girls
Authors: Mora Marisol , Penelo Eva , Gutiérrez Teresa , Espinoza Paola , González Marcela L. , Raich Rosa M.
Published: February 2015

Aims. To evaluate the long‐term effects of two school‐based prevention programs administered to a universal mixed‐sex sample of school‐going adolescents on disturbed eating attitudes, aesthetic ideal internalization, and other eating disorder risk factors, when compared to a control group. Methods. Participants were 200 adolescents aged 12–15 selected by means of incidental sampling from second‐year compulsory secondary education at schools. An interactive multimedia media literacy program (ML + NUT, Media Literacy and Nutrition) and a program focused on the same topics using dramatic arts (Theatre Alive) were applied and compared with a control group. Pretest, posttest (1 month later), and 5‐ and 13‐month follow‐up measurements were taken. Analyses were conducted with two‐way mixed 3 × 3 ANCOVA (group × phase) adjusted by baseline levels, body mass index, and sex. Results. Participants in both experimental groups showed significantly higher self‐esteem scores than the control group over time. The ML + NUT group also presented lower aesthetic ideal internalization scores than the control group. Discussion. Both programs can benefit students’ self‐esteem. Moreover, ML + NUT program was useful in reducing thin‐ideal internalization. However, differences in body dissatisfaction and disordered eating attitudes were not found. The programs may be protective on the core psychological variables, which are essential to adaptive adolescent development.
Image Denoising via Asymptotic Nonlocal Filtering
Authors: Liu Xiaoyan , Feng Xiangchu , Zhang Xuande , Li Xiaoping , Luo Liang
Published: February 2015

The nonlocal means algorithm is widely used in image denoising, but this algorithm does not work well for high-intensity noise. To overcome this shortcoming, we establish a coupled iterative nonlocal means model in this paper. Considering the computation complexity of the new model, we realize it by using multiscale wavelet transform and propose an asymptotic nonlocal filtering algorithm which can reduce the influence of noise on similarity estimation and computation complexity. Moreover, we build a new nonlocal weight function based on the structure similarity index. Simulation results indicate that the proposed approach cannot only remove the noise but also preserve the structure of image and has good visual effects, especially for highly degenerated images.
Novel Candidate Key Drivers in the Integrative Network of Genes, MicroRNAs, Methylations, and Copy Number Variations in Squamous Cell Lung Carcinoma
Authors: Huang Tao , Yang Jing , Cai Yu-dong
Published: February 2015

The mechanisms of lung cancer are highly complex. Not only mRNA gene expression but also microRNAs, DNA methylation, and copy number variation (CNV) play roles in tumorigenesis. It is difficult to incorporate so much information into a single model that can comprehensively reflect all these lung cancer mechanisms. In this study, we analyzed the 129 TCGA (The Cancer Genome Atlas) squamous cell lung carcinoma samples with gene expression, microRNA expression, DNA methylation, and CNV data. First, we used variance inflation factor (VIF) regression to build the whole genome integrative network. Then, we isolated the lung cancer subnetwork by identifying the known lung cancer genes and their direct regulators. This subnetwork was refined by the Bayesian method, and the directed regulations among mRNA genes, microRNAs, methylations, and CNVs were obtained. The novel candidate key drivers in this refined subnetwork, such as the methylation of ARHGDIB and HOXD3, microRNA let-7a and miR-31, and the CNV of AGAP2, were identified and analyzed. On three large public available lung cancer datasets, the key drivers ARHGDIB and HOXD3 demonstrated significant associations with the overall survival of lung cancer patients. Our results provide new insights into lung cancer mechanisms.
Disease-Modifying Drugs Reduce Cortical Lesion Accumulation and Atrophy Progression in Relapsing-Remitting Multiple Sclerosis: Results from a 48-Month Extension Study
Authors: Rinaldi Francesca , Perini Paola , Atzori Matteo , Favaretto Alice , Seppi Dario , Gallo Paolo
Published: February 2015

Cortical lesions (CLs) and atrophy are pivotal in multiple sclerosis (MS) pathology. This study determined the effect of disease modifying drugs (DMDs) on CL development and cortical atrophy progression in patients with relapsing-remitting MS (RRMS) over 48 months. Patients (n=165) were randomized to sc IFNβ-1a 44 μg, im IFNβ-1a 30 μg, or glatiramer acetate 20 mg. The reference population comprised 50 DMD-untreated patients with RRMS. After 24 months, 43 of the untreated patients switched to DMDs. The four groups of patients were followed up for an additional 24 months. At 48 months the mean standard deviation number of new CLs was significantly lower in patients treated with sc IFNβ-1a (1.4 ± 1.0, range 0–5) compared with im IFNβ-1a (2.3 ± 1.3, range 0–6,P=0.004) and glatiramer acetate (2.2 ± 1.5, range 0–7,P=0.03). Significant reductions in CL accumulation and new white matter and gadolinium-enhancing lesions were also observed in the 43 patients who switched to DMDs after 24 months, compared with the 24 months of no treatment. Concluding, this study confirms that DMDs significantly reduce CL development and cortical atrophy progression compared with no treatment.
Approximate Solution of Two-Dimensional Nonlinear Wave Equation by Optimal Homotopy Asymptotic Method
Authors: Ullah H. , Islam S. , Dennis L. C. C. , Abdelhameed T. N. , Khan I. , Fiza M.
Published: February 2015

The two-dimensional nonlinear wave equations are considered. Solution to the problem is approximated by using optimal homotopy asymptotic method (OHAM). The residual and convergence of the proposed method to nonlinear wave equation are presented through graphs. The resultant analytic series solution of the two-dimensional nonlinear wave equation shows the effectiveness of the proposed method. The comparison of results has been made with the existing results available in the literature.
Cementless Hydroxyapatite Coated Hip Prostheses
Authors: Herrera Antonio , Mateo Jesús , Gil-Albarova Jorge , Lobo-Escolar Antonio , Ibarz Elena , Gabarre Sergio , Más Yolanda , Gracia Luis
Published: February 2015

More than twenty years ago, hydroxyapatite (HA), calcium phosphate ceramics, was introduced as a coating for cementless hip prostheses. The choice of this ceramic is due to its composition being similar to organic apatite bone crystals. This ceramic is biocompatible, bioactive, and osteoconductive. These qualities facilitate the primary stability and osseointegration of implants. Our surgical experience includes the implantation of more than 4,000 cementless hydroxyapatite coated hip prostheses since 1990. The models implanted are coated with HA in the acetabulum and in the metaphyseal area of the stem. The results corresponding to survival and stability of implants were very satisfactory in the long-term. From our experience, HA-coated hip implants are a reliable alternative which can achieve long term survival, provided that certain requirements are met: good design selection, sound choice of bearing surfaces based on patient life expectancy, meticulous surgical technique, and indications based on adequate bone quality.
A Unique Case of Primary Ewing’s Sarcoma of the Cervical Spine in a 53-Year-Old Male: A Case Report and Review of the Literature
Authors: Holland Marshall T. , Flouty Oliver E. , Close Liesl N. , Reddy Chandan G. , Howard Matthew A.
Published: February 2015

Extraskeletal Ewing’s sarcoma (EES) is a rare presentation, representing only 15% of all primary Ewing’s sarcoma cases. Even more uncommon is EES presenting as a primary focus in the spinal canal. These rapidly growing tumors often present with focal neurological symptoms of myelopathy or radiculopathy. There are no classic characteristic imaging findings and thus the physician must keep a high index of clinical suspicion. Diagnosis can only be definitively made by histopathological studies. In this report, we discuss a primary cervical spine EES in a 53-year-old man who presented with a two-month history of left upper extremity pain and acute onset of weakness. Imaging revealed a cervical spinal canal mass. After undergoing cervical decompression, histopathological examination confirmed a diagnosis of Ewing’s sarcoma. A literature search revealed fewer than 25 reported cases of primary cervical spine EES published in the past 15 years and only one report demonstrating this pathology in a patient older than 30 years of ageage=38. Given the low incidence of this pathology presenting in this age group and the lack of treatment guidelines, each patient’s plan should be considered on a case-by-case basis until further studies are performed to determine optimal evidence based treatment.
High-Performance Grouting Mortar Based on Mineral Admixtures
Authors: Ma Cong , Tan Yuehu , Li Erbing , Dai Yinsuo , Yang Meng
Published: February 2015

A study on high-performance grouting mortar is reported. The common mortar was modified by mineral admixtures such as gypsum, bauxite, and alunite. The effects of mineral admixtures on the fluidity, setting time, expansion, strength, and other properties of mortar were evaluated experimentally. The microstructure of the modified mortar was characterized by X-ray diffraction, scanning electron microscopy, and mercury intrusion porosimetry. Moreover, the expansive performance and strength of the grouting mortar were verified by anchor pullout test. The results show that the best conditions for gypsum-bauxite grouting mortar are as follows: a water-to-binder ratio of 0.3, a mineral admixture content of ~15%, and a molar ratioKof 2. The ultimate bearing capacity of the gypsum-bauxite grouting mortar anchor increased by 39.6% compared to the common mortar anchor. The gypsum-bauxite grouting mortar has good fluidity, quick-setting, microexpansion, early strength, and high strength performances.
Performance of Size 1 I‐Gel Compared with Size 1 ProSeal Laryngeal Mask in Anesthetized Infants and Neonates
Authors: Kayhan Gulay Erdogan , Begec Zekine , Sanli Mukadder , Gedik Ender , Durmus Mahmut
Published: February 2015

Purpose. The size 1 I‐gel, recommended for small infants and neonates weighing 2–5 kg, has recently been released. There are no prospective studies available that assess the insertion conditions, sealing pressures, or ventilation quality of it. This study was designed to compare the performance of recently released size 1 I‐gel with size 1 ProSeal LMA. Methods. Fifty infants and neonates, ASA I‐II were included in this prospective, randomized, and controlled study. Patients were divided into two groups for placing I‐gel or ProSeal LMA. The primary outcome was airway leak pressure, and secondary outcomes included insertion time, insertion success and conditions, initial airway quality, fiberoptic view of the larynx, and complications. Results. There were no significant differences in terms of airway leak pressure between the I‐gel (27.44 ± 5.67) and ProSeal LMA (23.52 ± 8.15) (P = 0.054). The insertion time for the I‐gel was shorter (12.6 ± 2.19 s) than for the ProSeal LMA (24.2 ± 6.059 s) (P = 0.0001). Insertion success and conditions were similar in groups. We encountered few complications. Conclusion. Our study demonstrates that the size 1 I‐gel provided an effective and satisfactory airway as the size 1 ProSeal LMA. It may be a good alternative supraglottic airway device for use in small infants and neonates. This trial is registered with: ClinicalTrials.gov NCT01704118.
Solving the Multiscenario Max-Min Knapsack Problem Exactly with Column Generation and Branch-and-Bound
Authors: Pinto Telmo , Alves Cláudio , Mansi Raïd , Valério de Carvalho José
Published: February 2015

Despite other variants of the standard knapsack problem, very few solution approaches have been devised for the multiscenario max-min knapsack problem. The problem consists in finding the subset of items whose total profit is maximized under the worst possible scenario. In this paper, we describe an exact solution method based on column generation and branch-and-bound for this problem. Our approach relies on a reformulation of the standard compact integer programming model based on the Dantzig-Wolfe decomposition principle. The resulting model is potentially stronger than the original one since the corresponding pricing subproblem does not have the integrality property. The details of the reformulation are presented and analysed together with those concerning the column generation and branch-and-bound procedures. To evaluate the performance of our algorithm, we conducted extensive computational experiments on large scale benchmark instances, and we compared our results with other state-of-the-art approaches under similar circumstances. We focused in particular on different relevant aspects that allow an objective evaluation of the efficacy of our approach. From different standpoints, the branch-and-price algorithm proved to outperform the other state-of-the-art methods described so far in the literature.
Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation
Authors: Tang Jonathan , Huang Yurong , Nguyen David H. , Costes Sylvain V. , Snijders Antoine M. , Mao Jian-Hua
Published: February 2015

Long noncoding RNAs (lncRNAs) are emerging as key regulators of diverse cell functions and processes. However, the relevance of lncRNAs in the cell and tissue response to ionizing radiation has not yet been characterized. Here we used microarray profiling to determine lncRNA and mRNA expression in mammary glands of BALB/c and SPRET/EiJ mice after low-dose ionizing radiation (LDIR) exposure. We found that unirradiated mammary tissues of these strains differed significantly in baseline expressions of 290 lncRNAs. LDIR exposure (10 cGy) induced a significant change in the expression of many lncRNAs. The vast majority of lncRNAs identified to be differentially expressed after LDIR in either BALB/c or SPRET/EiJ had a significantly correlated expression pattern with at least one LDIR responsive mRNA. Functional analysis revealed that the response to LDIR in BALB/c mice is highly dynamic with enrichment for genes involved in tissue injury, inflammatory responses, and mammary gland development at 2, 4, and 8 weeks after LDIR, respectively. Our study demonstrates that genetic background strongly influences the expression of lncRNAs and their response to radiation and that lncRNAs may coordinate the tissue response to LDIR exposure via regulation of coding mRNAs.
An Alternating Variable Step-Size Adaptive Long-Range Prediction of LMS Fading Signals
Authors: Liao Xi , Xue Rui , Zhao Dan-feng , Wang Yang
Published: February 2015

We propose a linear alternating variable step-size adaptive long-range prediction (AVSS-ALRP) scheme to predict fading signals which is especially suitable for a versatile two-state land mobile satellite (LMS) channel model at S-band. A three-step design procedure is presented to optimize the prediction performance. Firstly, we establish the Gilbert-Elliot channel model based on first-order Markov chain for satellite communication downlink and take advantage of smoothing average to obtain channel observed values. At a second stage, eigenvalue decomposition method is applied to predict future long-range channel state instead of weighted prediction. Finally, combining variable step-size least mean squares and adaptive long-range prediction, we introduce the VSS-ALRP algorithm to predict LMS channel fading signals in the case of “ good” state, and the obtained prediction results would be revised based on the linear prediction of error when shadowing condition is in the “ bad” state. Simulation results show that the proposed scheme can not only offer an accurate prediction for long-range channel state and fading signals over the two-state Gilbert-Elliot channel model and greatly enhance the fading signals’ autocorrelation, but also have considerably better performance than long-range prediction (LRP) algorithm from the results of mean square error (MSE) and correlation coefficient.
Sensor Node Deployment Based on Electromagnetism-Like Algorithm in Mobile Wireless Sensor Networks
Authors: Özdağ Recep , Karcı Ali
Published: February 2015

The dynamic deployment of sensors in wireless networks significantly affects the performance of the network. However, the efficient application of dynamic deployments which determines the positions of the sensors within the network increases the coverage area of the network. As a result of this, dynamic deployment increases the efficiency of the wireless sensor networks (WSNs). In this paper, dynamic deployment was applied to WSNs which consist of mobile sensors by aiming at increasing the coverage area of the network with electromagnetism-like (EM) algorithm which is a population-based optimization algorithm. A new approach has been improved in calculating the coverage rate of the sensors by using binary detection model so as to carry out the dynamic deployments of sensors and it has been thought to reach realistic results efficiently. Simulation results have shown that the EM algorithm can be preferred in the dynamic deployment of mobile sensors within the wireless networks.
Untreated Isolated Sytolic Hypertension among Middle-Aged and Old Adults in the United States: Trends in the Prevalence by Demographic Factors During 1999–2010
Authors: Liu Xuefeng , Hoang Van Minh , Liu Yali , Brown Rachel L.W.
Published: February 2015

Isolated systolic hypertension (ISH) predominates hemodynamic hypertension subtypes and becomes a significant factor for cardiovascular and renal outcomes in middle-aged and old adults. The prevalence and changes of untreated ISH have not been fully investigated in this population. A total of 12,097 participants aged ≥40 years were selected from the National Health and Nutrition Examination Survey 1999–2010. The overall prevalence of untreated ISH was 15.2%. The prevalence decreased significantly from 16.8% in 1999–2004 to 13.5% in 2005–2010. Females, non-Hispanic blacks, and adults with low education had higher prevalence of untreated ISH than males, non-Hispanic whites, and adults with high education, respectively. Compared with 1999–2004, the prevalence of untreated ISH in 2005–2010 reduced in old adults (28.0% versus 37.7%), females (14.3% versus 19.5%), and non-Hispanic whites (12.7% versus 16.2%). The stratified prevalence of untreated ISH decreased in 2005–2010 in non-Hispanic white females (12.8% versus 18.6%) and females who did not attend college (16.9% versus 21.8%). Untreated ISH is more prevalent in old and female subjects, and significant improvements in these groups suggest that public health measures or changes are in the right direction.
Infinitely Many Eigenfunctions for Polynomial Problems: Exact Results
Authors: Chen Yi-Chou
Published: February 2015

LetFx, y=asxys+as-1xys-1+⋯+a0xbe a real-valued polynomial function in which the degreesofyinFx, yis greater than or equal to 1. For any polynomialyx, we assume thatT:Rx→Rxis a nonlinear operator withTyx=Fx, yx. In this paper, we will find an eigenfunctionyx∈Rxto satisfy the following equation:Fx, yx=ayxfor some eigenvaluea∈Rand we call the problemFx, yx=ayxa fixed point like problem. If the number of all eigenfunctions inFx, yx=ayxis infinitely many, we prove that (i) any coefficients ofFx, y, asx, as-1x,…, a0x, are all constants inRand (ii)yxis an eigenfunction inFx, yx=ayxif and only ifyx∈R.
Periodic and Chaotic Orbits of a Discrete Rational System
Authors: Lazaryan N. , Sedaghat H.
Published: February 2015

We study a rational planar system consisting of one linear-affine and one linear-fractional difference equation. If all of the system’s parameters are positive (so that the positive quadrant is invariant and the system is continuous), then we show that the unique fixed point of the system in the positive quadrant cannot be repelling and the system does not have a snap-back repeller. By folding the system into a second-order equation, we find special cases of the system with some negative parameter values that do exhibit chaos in the sense of Li and Yorke within the positive quadrant of the plane.
MALDI-TOF MS and CD Spectral Analysis for Identification and Structure Prediction of a Purified, Novel, Organic Solvent Stable, Fibrinolytic Metalloprotease fromBacillus cereusB80
Authors: Saxena Rajshree , Singh Rajni
Published: February 2015

The ability to predict protein function from structure is becoming increasingly important; hence, elucidation and determination of protein structure become the major steps in proteomics. The present study was undertaken for identification of metalloprotease produced byBacillus cereusB80 and recognition of characteristics that can be industrially exploited. The enzyme was purified in three steps combining precipitation and chromatographic methods resulting in 33.5% recovery with 13.1-fold purification of enzyme which was detected as a single band with a molecular mass of 26 kDa approximately in SDS-PAGE and zymogram. The MALDI-TOF MS showed that the enzyme exhibited 70–93% similarity with zinc metalloproteases from various strainsBacillussp. specifically fromBacillus cereusgroup. The sequence alignment revealed the presence of zinc-binding region VVVHEMCHMV in the most conserved C terminus region. Secondary structure of the enzyme was obtained by CD spectra and I-TASSER. The enzyme kinetics revealed a Michaelis constant(Km)of 0.140 μmol/ml andVmaxof 2.11 μmol/min. The application studies showed that the enzyme was able to hydrolyze various proteins with highest affinity towards casein followed by BSA and gelatin. The enzyme exhibited strong fibrinolytic, collagenolytic, and gelatinolytic properties and stability in various organic solvents.
Toll-Like Receptor Mediated Modulation of T Cell Response by Commensal Intestinal Microbiota as a Trigger for Autoimmune Arthritis
Authors: Rogier Rebecca , Koenders Marije I. , Abdollahi-Roodsaz Shahla
Published: February 2015

In autoimmune diseases, a disturbance of the balance between T helper 17 (Th17) and regulatory T cells (Tregs) is often observed. This disturbed balance is also the case in rheumatoid arthritis (RA). Genetic predisposition to RA confers the presence of several polymorphisms mainly regulating activation of T lymphocytes. However, the presence of susceptibility factors is neither necessary nor sufficient to explain the disease development, emphasizing the importance of environmental factors. Multiple studies have shown that commensal gut microbiota is of great influence on immune homeostasis and can trigger the development of autoimmune diseases by favoring induction of Th17 cells over Tregs. However the mechanism by which intestinal microbiota influences the Th cell balance is not completely understood. Here we review the current evidence supporting the involvement of commensal intestinal microbiota in rheumatoid arthritis, along with a potential role of Toll-like receptors (TLRs) in modulating the relevant Th cell responses to trigger autoimmunity. A better understanding of TLR triggering by intestinal microbiota and subsequent T cell activation might offer new perspectives for manipulating the T cell response in RA patients and may lead to the discovery of new therapeutic targets or even preventive measures.
Use of Adipose-Derived Mesenchymal Stem Cells in Keratoconjunctivitis Sicca in a Canine Model
Authors: Villatoro Antonio J. , Fernández Viviana , Claros Silvia , Rico-Llanos Gustavo A. , Becerra José , Andrades José A.
Published: February 2015

Keratoconjunctivitis sicca (KCS) or dry eye disease (DED) is an immune-mediated multifactorial disease, with high level of prevalence in humans and dogs. Our aim in this study was to investigate the therapeutic effects of allogeneic adipose-derived mesenchymal stromal cells (Ad-MSCs) implanted around the lacrimal glands in 12 dogs (24 eyes) with KCS, which is refractory to current available treatments. Schirmer tear test (STT) and ocular surface integrity were assessed at 0 (before treatment), 3, 6, and 9 months after treatment. Average STT values and all clinical signs showed a statistically significant change(P<0.001)during the follow-up with reduction in all ocular parameters scored: ocular discharge, conjunctival hyperaemia, and corneal changes, and there were no signs of regression or worsening. Implanted cells were well tolerated and were effective reducing clinical signs of KCS with a sustained effect during the study period. None of the animals showed systemic or local complications during the study. To our knowledge, this is the first time in literature that implantation of allogeneic Ad-MSCs around lacrimal glands has been found as an effective therapeutic alternative to treat dogs with KCS. These results could reinforce a good effective solution to be extrapolated to future studies in human.
The Relationship between Primary School Teacher and Student Attitudes towards Science and Technology
Authors: Denessen Eddie , Vos Nienke , Hasselman Fred , Louws Monika
Published: February 2015

This study focuses on the effects of teachers’ attitudes towards teaching about science and technology on student attitudes towards science and technology. A one-year longitudinal study involving 91 teachers and 1822 students from the higher years of Dutch primary schools showed that students develop less positive attitudes towards science and technology during their primary school years and that girls showed less positive attitudes than boys. Female teachers showed less positive attitudes towards teaching about science and technology than male teachers. Girls appeared to be susceptible of their teacher’s attitudes and especially developed less positive attitudes when their female teacher showed less enthusiasm for teaching science and technology. Implications for teacher education and teacher recruitment are discussed.
Pick’s Theorem in Two‐Dimensional Subspace of R3
Authors: Si Lin
Published: February 2015

In the Euclidean space , denote the set of all points with integer coordinate by . For any two‐dimensional simple lattice polygon P, we establish the following analogy version of Pick’s Theorem, k(I(P) + (1/2)B(P) − 1), where B(P) is the number of lattice points on the boundary of P in , I(P) is the number of lattice points in the interior of P in , and k is a constant only related to the two‐dimensional subspace including P.
Maternal Glucose during Pregnancy and after Delivery in Women with Gestational Diabetes Mellitus on Overweight Status of Their Children
Authors: Zhang Shuang , Liu Huikun , Zhang Cuiping , Wang Leishen , Li Nan , Leng Junhong , Li Yi , Liu Gongshu , Fan Xiangwei , Yu Zhijie , Yang Xilin , Baccarelli Andrea A. , Hou Lifang , Hu Gang
Published: February 2015

Objective. To examine the association of maternal glycemia during pregnancy and after delivery with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM).Methods. A total of 1,263 GDM mothers and their children finished the health survey at 1–5 years after delivery.Results. Offspring of GDM mothers who were diagnosed with diabetes during pregnancy had higher prevalence of overweight, higher mean weight for heightZscores, and higher mean BMI for ageZscores at 1–5 years old than the offspring of GDM mothers who were diagnosed with impaired glucose tolerance (IGT) during pregnancy. Offspring of GDM mothers who developed diabetes 1–5 years after delivery had higher mean values ofZscores for weight for height and BMI for age at 1–5 years old than the offspring of GDM mothers who had normal glucose or prediabetes after delivery.Conclusions. Offspring of GDM mothers who were diagnosed with diabetes during pregnancy or after delivery had an increased risk of childhood overweight or weight gain at 1–5 years old compared with children of GDM mothers with IGT during pregnancy or with normal glucose or prediabetes after delivery.
Velocity during Strength and Power Training of the Ankle Plantar and Dorsiflexor Muscles in Older Patients Attending Day Hospital Rehabilitation
Authors: Rajan Pavithra , Porter Michelle M.
Published: February 2015

Power training has been proposed as a more effective type of resistance training for older adults for functional performance. It is not yet known whether older adults respond appropriately to instructions for power versus strength training. The purpose of this study was to determine the velocity during strength and power training, with elastic resistance bands, in older adults attending a geriatric rehabilitation day program. It was hypothesized that power training would be faster than strength training, but that there would be large interindividual differences. Nine older patients (70 to 86 years) performed power and strength training of the ankle dorsiflexor and plantar flexor muscles using elastic resistance bands. Training sessions were filmed to assess the velocity of training. Power training occurred at faster velocities as compared to strength training (P<0.01) for both muscle groups. However, a wide variation was observed between participants in the training velocities. Older adults attending geriatric rehabilitation do have the potential to develop faster contractions during power training as compared to strength training. Nevertheless, the actual velocities achieved differed between individuals. This could explain some of the mixed findings of studies on power training. Hence, researchers should monitor velocity when comparing different types of resistance training.
Service Operations Optimization: Recent Development in Supply Chain Management
Authors: Shen Bin
Published: February 2015

Services are the key of success in operation management. Designing the effective strategies by optimization techniques is the fundamental and important condition for performance increase in service operations (SOs) management. In this paper, we mainly focus on investigating SOs optimization in the areas of supply chain management, which create the greatest business values. Specifically, we study the recent development of SOs optimization associated with supply chain by categorizing them into four different industries (i.e., e-commerce industry, consumer service industry, public sector, and fashion industry) and four various SOs features (i.e., advertising, channel coordination, pricing, and inventory). Moreover, we conduct the technical review on the stylish industries/topics and typical optimization models. The classical optimization approaches for SOs management in supply chain are presented. The managerial implications of SOs in supply chain are discussed.
Nonequilibrium Quantum Systems: Divergence between Global and Local Descriptions
Authors: Manrique Pedro D. , Rodríguez Ferney , Quiroga Luis , Johnson Neil F.
Published: February 2015

Even photosynthesis—the most basic natural phenomenon underlying life on Earth—involves the nontrivial processing of excitations at the pico- and femtosecond scales during light-harvesting. The desire to understand such natural phenomena, as well as interpret the output from ultrafast experimental probes, creates an urgent need for accurate quantitative theories of open quantum systems. However it is unclear how best to generalize the well-established assumptions of an isolated system, particularly under nonequilibrium conditions. Here we compare two popular approaches: a description in terms of a direct product of the states of each individual system (i.e., alocalapproach) versus the use of new states resulting from diagonalizing the whole Hamiltonian (i.e., aglobalapproach). The main difference lies in finding suitable operators to derive the Lindbladian and hence the master equation. We show that their equivalence fails when the system is open, in particular under the experimentally ubiquitous condition of a temperature gradient. By solving for the steady state populations and calculating the heat flux as a test observable, we uncover stark differences between the formulations. This divergence highlights the need to establish rigorous ranges of applicability for such methods in modeling nanoscale transfer phenomena—including during the light-harvesting process in photosynthesis.
Dynamic Programming-Based Energy Management System for Range-Extended Electric Bus
Authors: Wu Xiaogang , Chen Jingfu , Hu Chen
Published: February 2015

The heavy computational burden associated with the application of the traditional DP strategy to the energy management of range-extended electric buses poses a serious problem. On the basis of one Chinese typical urban bus driving cycle, an optimal control strategy is designed according to the SOC consumption trend, which is optimized by the DP algorithm. The dissipative energy and the energy-traction efficiency are our evaluation indices. The energy efficiencies of the powertrain system and components are analyzed by the energy flow diagram method. The results show that when the range-extended electric bus runs 35 Chinese typical urban bus driving cycles, the energy consumption and the energy efficiency of the powertrain system, which are optimized by the traditional DP strategy, can reach 2844.28 MJ and 31.29%, respectively. Compared with the traditional bus, the energy consumption can be reduced by 31.08%. The energy consumption and the energy efficiency of the powertrain system, which are based on one driving cycle optimal strategy, can reach 2857.69 MJ and 31.14%, respectively. The energy consumption is 0.47% higher than that with the traditional DP strategy, but the computation time is reduced by 96.85%.
Biodiversity andγ-Aminobutyric Acid Production by Lactic Acid Bacteria Isolated from Traditional Alpine Raw Cow’s Milk Cheeses
Authors: Franciosi Elena , Carafa Ilaria , Nardin Tiziana , Schiavon Silvia , Poznanski Elisa , Cavazza Agostino , Larcher Roberto , Tuohy Kieran M.
Published: February 2015

“Nostrano-cheeses” are traditional alpine cheeses made from raw cow’s milk in Trentino-Alto Adige, Italy. This study identified lactic acid bacteria (LAB) developing during maturation of “Nostrano-cheeses” and evaluated their potential to produceγ-aminobutyric acid (GABA), an immunologically active compound and neurotransmitter. Cheese samples were collected on six cheese-making days, in three dairy factories located in different areas of Trentino and at different stages of cheese ripening (24 h, 15 days, and 1, 2, 3, 6, and 8 months). A total of 1,059 LAB isolates were screened using Random Amplified Polymorphic DNA-PCR (RAPD-PCR) and differentiated into 583 clusters. LAB strains from dominant clusters (n=97) were genetically identified to species level by partial 16S rRNA gene sequencing. LAB species most frequently isolated wereLactobacillus paracasei,Streptococcus thermophilus, andLeuconostoc mesenteroides. The 97 dominant clusters were also characterized for their ability in producing GABA by high-performance liquid chromatography (HPLC). About 71% of the dominant bacteria clusters evolving during cheeses ripening were able to produce GABA. Most GABA producers wereLactobacillus paracaseibut other GABA producing species includedLactococcus lactis,Lactobacillus plantarum,Lactobacillus rhamnosus,Pediococcus pentosaceus, andStreptococcus thermophilus. NoEnterococcus faecalisorSc. macedonicusisolates produced GABA. The isolate producing the highest amount of GABA (80.0±2.7 mg/kg) was aSc. thermophilus.
Evaluation of Pediatric Manual Wheelchair Mobility Using Advanced Biomechanical Methods
Authors: Slavens Brooke A. , Schnorenberg Alyssa J. , Aurit Christine M. , Graf Adam , Krzak Joseph J. , Reiners Kathryn , Vogel Lawrence C. , Harris Gerald F.
Published: February 2015

There is minimal research of upper extremity joint dynamics during pediatric wheelchair mobility despite the large number of children using manual wheelchairs. Special concern arises with the pediatric population, particularly in regard to the longer duration of wheelchair use, joint integrity, participation and community integration, and transitional care into adulthood. This study seeks to provide evaluation methods for characterizing the biomechanics of wheelchair use by children with spinal cord injury (SCI). Twelve subjects with SCI underwent motion analysis while they propelled their wheelchair at a self-selected speed and propulsion pattern. Upper extremity joint kinematics, forces, and moments were computed using inverse dynamics methods with our custom model. The glenohumeral joint displayed the largest average range of motion (ROM) at 47.1° in the sagittal plane and the largest average superiorly and anteriorly directed joint forces of 6.1% BW and 6.5% BW, respectively. The largest joint moments were 1.4% body weight times height (BW ×H) of elbow flexion and 1.2% BW ×Hof glenohumeral joint extension. Pediatric manual wheelchair users demonstrating these high joint demands may be at risk for pain and upper limb injuries. These evaluation methods may be a useful tool for clinicians and therapists for pediatric wheelchair prescription and training.