bluuebunny/crossref_metadata_2025 huggingface dataset:
Reforma del Código del Derecho foral de Aragón en materia de discapacidad (Ley 3/2024, de 13 de junio)
Authors: Arbués Aísa David , Bayod López Carmen , Calatayud Sierra Adolfo , García Vicente Fernando , López Azcona Aurora , Oria Almudí Joaquín , Serrano García José Antonio
Published: September 2024

El pasado 13 de junio de 2024 las Cortes de Aragón aprobaron, por unanimidad, incluso en las escasas enmiendas presentadas al proyecto de ley, la modificación del Código del Derecho foral de Aragón en materia de capacidad jurídica de las personas. Todo un éxito sin precedentes que pone en valor la labor ejemplar de las Cortes, propia de Aragón y de los aragoneses. Esta obra, escrita por los miembros de la actual Comisión Aragonesa de Derecho civil tiene por objeto facilitar a los operadores jurídicos los primeros comentarios sobre la reforma, ofreciendo cada uno de los comentaristas las consideraciones y reflexiones que se tuvieron en cuenta en el seno de la Comisión y, en particular, en cada una de las ponencias internas en las que cada uno de nosotros trabajamos más directamente. La finalidad de estos comentarios no es otra que poner nuestro trabajo al servicio de los ciudadanos y facilitar, a ser posible, la labor de todos aquellos que tienen que aplicar la ley: abogados, fiscales, jueces, notarios, registradores, así como las diversas administraciones, pero, sobre todo, el uso y utilidad del Derecho civil por cada uno de los ciudadanos al regular esta reforma la capacidad jurídica de las personas para intervenir en tráfico jurídico, poniendo a su disposición las herramientas precisas para que, en el ejercicio de su libertad civil, Standum est chartae, puedan actuar ejercitando su capacidad jurídica bien por sí solos o bien con los apoyos que puedan necesitar. Esperamos haberlo conseguido. Carmen Bayod López Presidenta de la Comisión Aragonesa de Derecho civil
CAPACIDAD JURÍDICA DE LAS PERSONAS CON DISCAPACIDAD
Authors: Serrano García José Antonio
Published: September 2024

El pasado 13 de junio de 2024 las Cortes de Aragón aprobaron, por unanimidad, incluso en las escasas enmiendas presentadas al proyecto de ley, la modificación del Código del Derecho foral de Aragón en materia de capacidad jurídica de las personas. Todo un éxito sin precedentes que pone en valor la labor ejemplar de las Cortes, propia de Aragón y de los aragoneses. Esta obra, escrita por los miembros de la actual Comisión Aragonesa de Derecho civil tiene por objeto facilitar a los operadores jurídicos los primeros comentarios sobre la reforma, ofreciendo cada uno de los comentaristas las consideraciones y reflexiones que se tuvieron en cuenta en el seno de la Comisión y, en particular, en cada una de las ponencias internas en las que cada uno de nosotros trabajamos más directamente. La finalidad de estos comentarios no es otra que poner nuestro trabajo al servicio de los ciudadanos y facilitar, a ser posible, la labor de todos aquellos que tienen que aplicar la ley: abogados, fiscales, jueces, notarios, registradores, así como las diversas administraciones, pero, sobre todo, el uso y utilidad del Derecho civil por cada uno de los ciudadanos al regular esta reforma la capacidad jurídica de las personas para intervenir en tráfico jurídico, poniendo a su disposición las herramientas precisas para que, en el ejercicio de su libertad civil, Standum est chartae, puedan actuar ejercitando su capacidad jurídica bien por sí solos o bien con los apoyos que puedan necesitar. Esperamos haberlo conseguido.
INVALIDEZ E INEFICACIA DE ACTOS Y CONTRATOS
Authors: Bayod López Carmen
Published: September 2024

El pasado 13 de junio de 2024 las Cortes de Aragón aprobaron, por unanimidad, incluso en las escasas enmiendas presentadas al proyecto de ley, la modificación del Código del Derecho foral de Aragón en materia de capacidad jurídica de las personas. Todo un éxito sin precedentes que pone en valor la labor ejemplar de las Cortes, propia de Aragón y de los aragoneses. Esta obra, escrita por los miembros de la actual Comisión Aragonesa de Derecho civil tiene por objeto facilitar a los operadores jurídicos los primeros comentarios sobre la reforma, ofreciendo cada uno de los comentaristas las consideraciones y reflexiones que se tuvieron en cuenta en el seno de la Comisión y, en particular, en cada una de las ponencias internas en las que cada uno de nosotros trabajamos más directamente. La finalidad de estos comentarios no es otra que poner nuestro trabajo al servicio de los ciudadanos y facilitar, a ser posible, la labor de todos aquellos que tienen que aplicar la ley: abogados, fiscales, jueces, notarios, registradores, así como las diversas administraciones, pero, sobre todo, el uso y utilidad del Derecho civil por cada uno de los ciudadanos al regular esta reforma la capacidad jurídica de las personas para intervenir en tráfico jurídico, poniendo a su disposición las herramientas precisas para que, en el ejercicio de su libertad civil, Standum est chartae, puedan actuar ejercitando su capacidad jurídica bien por sí solos o bien con los apoyos que puedan necesitar. Esperamos haberlo conseguido.
STRATEGIC APPROACHES TO LEAN MANUFACTURING IN INDUSTRY 4.0: A COMPREHENSIVE REVIEW STUDY
Authors:   Master in Engineering Management, Department of Industrial Engineering, Lamar University, Texas, USA, Begum Shirin , Sumi Sayeda Sufia ,   Sayeda Sufia Sumi Master in Industrial Engineering, Department of Industrial Engineering, Lamar University, Texas, USA
Published: September 2024

This systematic review, based on the analysis of 130 peer-reviewed articles, explores the strategic integration of lean manufacturing with Industry 4.0 technologies, focusing on the role of the Internet of Things (IoT), artificial intelligence (AI), and big data analytics in enhancing lean practices. Using the PRISMA guidelines, the study identified key synergies between lean and Industry 4.0, demonstrating how these technologies facilitate real-time data collection, predictive maintenance, and process optimization, all of which align with lean’s core principles of waste reduction and continuous improvement. The review also highlights significant challenges to this integration, including high implementation costs, workforce skill gaps, and resistance to organizational change, particularly within small and medium-sized enterprises. Additionally, emerging trends suggest that the future of lean-Industry 4.0 integration will increasingly focus on sustainability, with companies leveraging digital tools to enhance energy efficiency and reduce environmental waste. The findings underscore the need for further research to address these challenges and explore scalable solutions that can drive the broader adoption of lean-Industry 4.0 integration in diverse industrial contexts.
O PAPEL DAS COMPRAS PÚBLICAS EM DEFESA COMO O NOVO VETOR DE DESENVOLVIMENTO NACIONAL
Authors: Abreu Bianca Veloso de Lacerda
Published: September 2024

This article discusses the importance of the defense industry as a driver of innovation and economic growth in the country. With the intensification of geopolitical challenges and the need to modernize the Armed Forces, Brazil has invested in acquisitions that encourage research and technological development. The proposed research analyzes how these strategic public purchases can not only strengthen military capacity, but also stimulate national industry, generating skilled jobs and promoting technology transfer. Collaboration between the government and the private sector is essential to maximize the benefits of these acquisitions, allowing technological advances to have a positive impact on various sectors such as health, energy and transport. In addition, these defense acquisitions can serve as an industrial policy tool, guiding investments in priority areas and contributing to the country's strategic autonomy.  In this context, the research aims to demonstrate how defense acquisitions and orders are an essential vector for economic and technological development, with the potential to transform industrial capacity and national competitiveness in a global scenario.
Matthias Senn, Geschichte der evangelisch-reformierten Kirchgemeinde zum Grossmünster Zürich 1833-2018, 2021
Authors: Engeler Judith
Published: September 2024

No abstract available.
Jon D. Wood, Reforming Priesthood in Reformation Zurich, 2019
Authors: Csukás Gergely
Published: September 2024

No abstract available.
Der Gelehrte, der Schüler und ein Gimpelpaar: Ein vergessener griechischer Brief von Conrad Gessner an Johannes Pontisella III.
Authors: Bernhard Jan-Andrea , Müller Clemens
Published: September 2024

In the collection of funeral poems (epicedia) for Conrad Gessner published by Josias Simler in 1566 along with a biography of the deceased, two distichs stand out. They were penned by then 14-year-old Johannes Pontisella; one in Latin, one in Greek. An inconspicuous letter draft from Gessner to 12-year-old Pontisella in manuscript ZBZ Ms C 50a has recently been discovered to further document the relationship between Gessner and young Pontisella. This essay outlines the biography of Johannes Pontisella III. (1552–1622) and his family, who originated in the Val Bregaglia. It illustrates the friendship between Johannes Pontisella II. (ca. 1510–1574) and Gessner, which was based, among other things, on their common interest in botanical and zoological matters, as well as the relationship of Pontisella III. with Zurich’s scholarly society. It furthermore discusses the tradition of humanist Greek funeral poetry (epicedia) and epistolography of the time in general and for Gessner in particular, analyzing his letter to Pontisella III. on a linguistic level and within the context of education in the 16th-century Grisons. The description of “mountain bullfinches” in Gessner’s letter is discussed in the context of his ornithological studies. A bilingual, annotated edition of Pontisella’s epicedia and Gessner’s letter draft concludes the essay.
Claude-Eric Descoeudres (Hg.), Desiderius Erasmus von Rotterdam: Adagia / Sprichwörter, 2021
Authors: Christ-von Wedel Christine
Published: September 2024

No abstract available.
Die Zürcher Hexenprozesse und die Reformatoren
Authors: Christ-von Wedel Christine
Published: September 2024

In the archives in Zurich, there are 230 sorcery trials during 1570 and 1630, among which 80 trials are death sentences. During 1521 and 1531, when Zwingli’s opinion was of dominant importance, only one witch was sentenced under a particular circumstance. Zwingli never addressed contemporary magic, sorcery, or the pact with the devil, which were the main accusations that the witches were blamed for. He even avoided speaking of witches in his exegesis of Exodus 22:17 (18). Bullinger was less reserved. He certainly believed in witchcraft, blamed witches of the pact with the devil, and called for death sentences. However, though he had already discussed sorcery in his Decades in the middle of the sixteenth century, only twenty years later, the number of sorcery trials increased in Zurich, while the fear of demonic attacks caused many witch hunts in the Little Ice Age all over Europe.
Reinhard Bodenmann et al. (Hg.), Heinrich Bullinger. Briefwechsel, Bd. 20, 2022
Authors: Nelson Burnett Amy
Published: September 2024

No abstract available.
Urs B. Leu / Sandra Weidmann, Der bibliophile Reformator: Rudolf Gwalthers Privatbibliothek, 2020
Authors: Steiniger Judith
Published: September 2024

No abstract available.
Katholische Kuriositäten: Aufarbeitung der Bedeutung und Funktion von Kuriositäten mit katholischem Hintergrund in der frühen Neuzeit, anhand der Sammlung der Bürgerbibliothek im reformierten Winterthur
Authors: Mäder-Esteves Andreas
Published: September 2024

This article presents an inquiry into the topic of catholic coded curiosities in protestant owned curiosity collections in the early modern period. The specific object of this investigation is the curiosity collections of the Library of Winterthur in Switzerland during the 17th and 18th century. This collection contained several objects of catholic origins, which didn't seem to distinguish themselves threw rarity, exoticism or value, like other curiosities typically would. Therefore, the question arose why these objects were part of the collection. This article tries to answer this question by the following argumentation: The protestant reformation brought with it a new ethos of education. Literacy and learning were promoted, so the believers could read and understand the bible. This new ethos, which saw education as a religious good, also led to the founding of libraries in many protestant cities. This reframes the catholic objects. If the library is seen as a place of education closely tied to religious goals, the catholic objects appear as part of the protestant educational project. Therefore, the catholic curiosities can be understood as pedagogical tools to teach the protestant citizens about the “false” teachings of catholicism as well as the history of the reformation.
Bernhard Stettler, Überleben in schwieriger Zeit: Die 1530er und 1540er Jahre im Spiegel von Vadians Korrespondenz, 2014
Authors: Heimbucher Martin
Published: September 2024

No abstract available.
Florian Hitz et al. (Hg.), Ulrich Campell: Das alpine Rhätien, 2021
Authors: Leu Urs B.
Published: September 2024

No abstract available.
Andreas Bodenstein von Karlstadt: Kritische Gesamtausgabe der Schriften und Briefe, Band 2: Briefe und Schriften 1519, 2019
Authors: Leu Urs B.
Published: September 2024

No abstract available.
Mona Garloff / Christian Volkmar Witt (Hg.), Confessio im Konflikt: Religiöse Selbst- und Fremdwahrnehmung in der Frühen Neuzeit, 2019
Authors: Steinemann Manuela
Published: September 2024

No abstract available.
Schweizerische Drucke in den bürgerlichen frühneuzeitlichen Privatbibliotheken in den Prager Städten
Authors: Fejtová Olga , Pešek Jiří
Published: September 2024

Based on an analysis of the probate inventories of the burghers of the New Town of Prague in the 17th century, the paper identifies religious and secular literature produced by Swiss printers in Prague burgher private libraries and examines its occurrence in the context of the development of a multi-confessional society in Bohemia before the Thirty Years’ War and subsequently in the phase of the recatholization policy towards a mono-confessional Catholic society. The prints of Swiss printers are analysed in the context of their contemporary offer on the Central European book market in Frankfurt a. M., which was mainly imported to Prague by Nuremberg merchants, and also in the context of the local Prague market, which offered titles by Swiss authors in translation. The reception of Swiss printed literature in the Prague towns is compared with the situation in one of the typical royal towns in Bohemia. The role of the Unity of Brothers in the reception of the production of Swiss printers is also taken into account.
Christian Link, Die Theologie Calvins im Rahmen der europäischen Reformation, 2021
Authors: Assonville Victor E. d’
Published: September 2024

No abstract available.
In der «Schule göttlicher Weisheit»
Authors: Baschera Luca
Published: September 2024

Bullinger uses the term philosophia Christi in the prefaces to his Commentary on 1 John and the collected edition of his commentaries on the New Testament epistles to describe what his readers should expect to learn from the Bible. This article first explores Bullinger’s use of the term ‘philosophy of Christ’ in the corpus of his commentaries. Next, it sketches the development of the term from its origin in the patristic period up to the time of Dutch humanist Erasmus in the early modern period. A consideration of the multifaceted influence Erasmus and his understanding of philosophia Christi exerted on Bullinger and, more broadly, on the Zurich Reformed milieu concludes the discussion.
Rainer Henrich / René Specht (Hg.), Johann Conrad Ulmer (1519–1600): Vollender der Reformation in Schaffhausen, 2020
Authors: Engeler Judith
Published: September 2024

No abstract available.
Urs B. Leu / Sandra Weidmann, Huldrych Zwingli’s Private Library, 2019
Authors: Berger-Gehringer Andreas
Published: September 2024

No abstract available.
Mit Liebe und Sanftmut eines Besseren belehren: Die lange Reformation als anhaltende Krise der Autorität
Authors: Berger-Gehringer Andreas
Published: September 2024

This article examines the conflict between Antoine Lescaille and the two pastors Léonard Constant and Jacques Couet of the French church of Basel. In 1590, Lescaille criticized the pastors’ teachings on the doctrine of justification. He expected to be properly instructed on his alleged errors and mistakes subsequently, however, the pastors insisted that as a layman he could not truly understand the complexity of the subject to begin with. Rather than exhaustively explain the theological doctrine of the Justification, the pastors approached Lescaille with «love and humility,» hoping this would help restore his trust in the French church and the pastors’ teachings. By examining this conflict and the French church’s strategies to handle Lescaille, this article illuminates how the long Reformation was driven by a clerical institutionalization of the Protestant church by the end of the 16th century, and how the long Reformation must be understood as an ongoing crisis of authority.
Eberhard Nehlsen / Christian Scheidegger (Hg.), Zürcher Liedflugschriften: Katalog der bis 1650 erschienenen Drucke in der Zentralbibliothek Zürich, 2021
Authors: Missfelder Jan-Friedrich
Published: September 2024

No abstract available.
Martin Ernst Hirzel / Frank Mathwig (Hg.), »... zu dieser dauernden Reformation berufen«: Das Zweite Helvetische Bekenntnis, 2020
Authors: Velinsky Mona
Published: September 2024

No abstract available.
Tai Chi, Qigong and the Treatment of Ankylosing Spondylitis
Authors: McGee Robert W
Published: September 2024

Tai chi and qigong have been used as primary or supplementary treatments for a wide range of diseases and ailments for hundreds, or even thousands of years in China. These two treatment techniques have been incorporated into western medical practices with increasing frequency in recent decades to treat a wide range of ailments, including fatigue, cancer, hypertension, depression, COPD, stroke, balance, heart disease and osteoporosis, to name a few. The present study summarizes the results of a literature search intended to find studies where tai chi or qigong have been used to treat ankylosing spondylitis. Several studies were found to have used tai chi or qigong to successfully treat ankylosing spondylitis symptoms.
Investment Strategies Based on Fundamental Stock Analysis
Authors: Viktorovich Bazyliev Viacheslav
Published: September 2024

Fundamental stock analysis is a methodology aimed at researching the financial performance and competitive advantages of a company in order to assess its investment attractiveness. The main focus is on analyzing revenue growth, profitability and sustainability of the company in the market, as well as macroeconomic conditions such as the general state of the economy and market demand. Effective management plays a key role in a company’s ability to overcome difficulties and seize opportunities to increase value. Investors use fundamental analysis to evaluate the company’s financial statements and determine its fair value, which allows them to identify undervalued and overvalued financial instruments. This method includes analysis at three levels: macroeconomic, industry, and company-specific levels, using various financial ratios and multipliers. Thus, fundamental analysis contributes to making informed investment decisions based on an objective assessment of the value of shares.
Perbandingan Legal Standing Pengajuan Judicial Review untuk Warga Negara Asing di Negara Indonesia dan Negara Jerman
Authors: Fikriya Makhyatul , Jaelani Elan , Rosidin Utang
Published: September 2024

Dalam Teori Negara Hukum Rechtstaats yang di gagasnya, Julius Stahl menyatakan bahwa setidaknya ada 4 prinsip dasar yang harus terpenuhi sebagai negara yang salah satu di antaranya adalah menjunjung tinggi Hak Asasi Manusia. Maka Indonesia sebagai Negara hukum haruslah menjunjung tinggi hak Asasi. Namun pada faktanya terdapat problematika dalam implemantasinya. Yakni tidak ada hak warga negara asing untuk mendapatkan legal standing dalam pengujian UU. Untuk itu perlu adanya studi komparasi hukum di Indonesia dengan hukum negara lain dalam hal ini negara Jerman. Metode Penelitian yang digunakan dalam penelitian  yaitu  Penelitian  Yuridis  Normatif  adalah  Metode  penelitian  hukum  yang dilakukan  dengan  cara  meneliti  bahan  pustaka  atau  bahan  sekunder. Hasil penelitian menunjukkan data dan informasi perbedaan antara Legal Standing Pengajuan Judicial Review untuk Warga Negara Asing di Negara Indonesia dan Negara Jerman.
Peran Generasi Muda dalam Pendidikan Politik untuk Meningkatkan Partisipasi Politik
Authors: Riyanti Ratna , Luthfi Amir , Rohana Dian
Published: September 2024

Peran generasi muda dalam mengembangkan dan meningkatkan partisipasi politik melalui pendidikan politik. Dalam era modern ini, partisipasi politik menjadi fondasi demokrasi yang kuat, dan generasi muda dianggap sebagai agen perubahan yang penting. Pendidikan politik berperan dalam membangun kesadaran politik di kalangan generasi muda. Dengan memahami prinsip-prinsip dasar politik, termasuk struktur pemerintahan, hak dan kewajiban warga negara, generasi milenial dapat mengembangkan pemahaman yang lebih mendalam tentang pentingnya partisipasi dalam proses politik. Peran pendidikan politik dalam membentuk pemahaman yang lebih mendalam tentang sistem politik, hak-hak warga, dan tanggung jawab sebagai pemilih. Generasi muda memiliki potensi besar untuk memperluas jangkauan partisipasi politik, terutama melalui penerapan teknologi informasi dan media sosial. Artikel ini juga membahas dampak positif yang dapat dicapai melalui keterlibatan aktif generasi muda dalam diskusi politik, kampanye pemilihan, dan kegiatan partisipatif lainnya.
Pendidikan Politik Generasi Muda Melalui Pendekatan Budaya Populer
Authors: Nasution Salman , Hafizsutrisno Hafizsutrisno
Published: September 2024

Alasan penulis tertarik dengan penelitian ini untuk mengetahui peran agen pendidikan politik terhadap partisipasi politik . Selain itu, penelitian ini juga bertujuan untuk mengetahui motivasi serta bentuk pendidikan politik dalam partisipasi politik pemilih muda. Hal ini diharap dapat memberi pendidikan politik untuk para generasi muda atau pemilih muda dalam mengikuti partisipasi politik pada pemilu legislative yang selanjutnya. Pendidikan politik bagi generasi muda dapat membuat mereka berperan aktif untuk memberikan gagasan mereka untuk para pemimpin politik yang relevan dengan kehidupan mereka, serta bisa memperkecil kesenjangan yang terjadi antara elite dan pemuda dengan upaya kritis terhadap politik serta partisipasi terhadap Politik.Melalui pendekatan-pendekatan budaya popular dengan anak muda seperti Media sosial dan memahami Perilaku anak muda atau Gen Z.Pendekatan menggunakan budaya popular terhadap anak muda untuk berpartisipasi dalam partai politik dan dapat mempengaruhi secara signifikan terhadap partisipasi pemilih pada Pemilihan Umum 2024.
Memahami Kekerasan dalam Pacaran Secara Resiprokal: Studi Kasus tentang Dinamika Hubungan yang Melibatkan Kekerasan Gegar Beralasan
Authors: Ramadhatsani Sahira , Apsari Nurliana Cipta , Taftazani Budi Muhammad
Published: September 2024

Artikel ini berfokus dalam menjelaskan fenomena kekerasan dalam pacarana secara resiprokal. Ini mencakup pentingnya kesadaran terhadap masalah ini dan dampaknya yang serius, serta berbagai bentuk kekerasan yang mungkin tidak disadari oleh banyak orang. Penekanan pada kekerasan fisik, emosional, seksual, dan ekonomi memberikan gambaran yang komprehensif tentang kompleksitas masalah ini. Selain itu, pendekatan teoritis dan penelitian kualitatif yang digunakan dalam artikel ini memberikan sudut pandang yang beragam dan mendalam terhadap isu tersebut. Pada akhirnya, abstrak ini menyoroti pentingnya keberanian dan tekad dalam keluar dari hubungan yang tidak sehat. Ini tidak hanya menekankan pentingnya kesadaran akan dampak kesehatan mental dan emosional yang serius, tetapi juga menekankan perlunya dukungan sosial, terapi, dan penyesuaian diri untuk memulai perjalanan menuju pemulihan dan kebahagiaan yang lebih baik.
Saito Kohei, El Capital en la Era del Antropoceno. Penguin Random House Grupo Editorial, 2022
Authors: Cantú Nájera Isael Petronio
Published: September 2024

Kohei Saito (1987, Tokio, Japón) ha des-articulado, con su libro “El capital en la era del Antropoceno” el sentimiento positivo y reconfortante de la pequeña burguesía que sentía que con sus acciones ecológicas podría detener el desastre que se cierne sobre la humanidad ante el fenómeno del calentamiento global.
Actos como sembrar un árbol, gestionando la basura, reduciendo, reciclando o reutilizándola o comprando un vehículo eléctrico, no servirán de nada mientras la esencia o núcleo de la transformación de las condiciones climatológicas sea el resultado de la forma dominante de producción: el capitalismo.
Pharmacogenomic Profiling to Tailor Antidepressant Therapy: Improving Treatment Outcomes and Reducing Adverse Drug Reactions in Major Depressive Disorder
Authors: Huang Muyi , Pan Haoyuan
Published: September 2024

Major Depressive Disorder (MDD) presents a significant challenge in clinical practice due to the variability in patient responses to antidepressants and the high incidence of adverse drug reactions (ADRs). The traditional trial-and-error approach to prescribing antidepressants often results in prolonged treatment periods, increased patient suffering, and higher healthcare costs. This study investigates the benefits of pharmacogenomic profiling to tailor antidepressant therapy, aiming to improve treatment outcomes and reduce ADRs. The primary objectives of this study were to evaluate the efficacy of personalized medication selection based on genetic profiles, reduce the time to achieve therapeutic efficacy, and enhance patient safety by minimizing ADRs. Pharmacogenomic testing methodologies, including genotyping and whole genome sequencing, were employed to identify genetic polymorphisms affecting drug metabolism and response. Key findings indicate that personalized antidepressant therapy increases response rates by 20-30% and reduces the time to symptom relief by 50%. The incidence of ADRs was decreased by 40-50% through tailored dosing and medication selection. Additionally, pharmacogenomic profiling identified 90% of high-risk patients before treatment, enabling preventive measures and personalized interventions. Dosage accuracy improved by 25-35%, contributing to better treatment outcomes. Economic analysis revealed substantial cost savings, with average annual savings of $2,000-$4,000 per patient and potential healthcare system savings of $100 million annually. The adoption of pharmacogenomic testing has increased from 5% to 25% of clinics over the past five years, demonstrating growing recognition of its clinical utility. This study underscores the transformative potential of pharmacogenomic profiling in optimizing antidepressant therapy, enhancing patient care, and reducing healthcare costs. Future research should focus on expanding genetic panels, increasing population diversity, and developing strategies for broader clinical integration.
A formação inicial na licenciatura em educação do campo dirigida para formação humana
Authors: Bonfim Luiz Jesus Santos , Marques Eliana Alencar
Published: September 2024

O presente artigo apresenta resultados parciais de uma pesquisa que teve como objetivo analisar em contexto de pesquisa-formação onto-crítica, o processo de constituição da formação inicial docente na licenciatura em educação do campo dirigida para a formação humana em uma perspectiva histórico crítica. Participaram da pesquisa quatro estudantes da Licenciatura em Educação do Campo com habilitação em Ciências da Natureza. A pesquisa foi desenvolvida nos pressupostos teórico-metodológicos do materialismo histórico-dialético, da psicologia histórico-cultural e da pedagogia histórico-crítica. Como metodologia utilizou-se a pesquisa-formação onto-crítica por meio de dispositivos para formação e produção de dados: relatórios e projetos, encontros formativos, diários formativos. Os dados foram analsiados a partir dos núcleos de significação. Os resultados da pesquisa revelam que a formação inicial na LEdoC se dirige para formação humana em uma perspectiva histórico crítica, quando é mediada por uma teoria pedagógica crítico radical, que possibilita o desenvolvimento de significações da atividade de ensino, como condição para promover a compreensão da prática social para além da aparência fenomênica. É necessário então, criar condições para que no processo de formação inicial se desenvolva significações da importância da mediação do conhecimento historicamente acumulado presente nos conceitos científicos como condição do desenvolvimento das máximas capacidades humanas que engendrem a compreensão crítica da realidade e sua transformação qualitativa. As signficações das participantes vão ao encontro dessa compreensão ao revelarem que o motivo da atividade do professor passa ser o desenvolvimento do aluno por meio do estudo e da aprendizagem teórica das legalidade naturais e sociais.
Gamificação e conceitos matemáticos na Educação de Jovens e Adultos
Authors: Trentin Valéria Becher , Trentin Luciano
Published: September 2024

A Educação de Jovens e Adultos (EJA) surge com o desafio de atender jovens e adultos em suas trajetórias humanas. Portanto, a finalidade dessa modalidade, não pode ser somente a de suprir carências de escolarização, devendo também garantir direitos específicos. No conjunto desses sujeitos, encontram-se jovens e adultos que buscam, no acesso à educação, meios para dar continuidade ao seu desenvolvimento humano e social. Sendo assim, podemos destacar que esta modalidade de ensino se insere no cenário educacional brasileiro com questões específicas no que se refere às práticas pedagógicas. Considerando a necessidade de práticas pedagógicas que abarquem a compreensão das relações e das condições sociais dos jovens e adultos, no presente artigo, traz-se para o debate a gamificação e a aprendizagem dos conceitos matemáticos nesta modalidade de ensino. Em termos metodológicos, empregaram-se os referenciais da pesquisa qualitativa, utilizando a observação para coleta de dados. A pesquisa teve como sujeitos uma professora e seus respectivos alunos da turma de Nivelamento 1º Segmento, de um Centro de Educação de Jovens e Adultos (CEJA), localizado em um município do estado de Santa Catarina. Constatou-se que a aprendizagem baseada na gamificação favorece o desenvolvimento de competências cada vez mais importantes e necessárias para o século XXI, como a resolução de problemas, a literacia digital e o pensamento crítico e a colaboração entre pares.
Educação a distância e identidade profissional docente
Authors: Coutinho Hebert Rogério do Nascimento , Carvalho Antonia Dalva França , Alcoforado Joaquim Luis Medeiros
Published: September 2024

No Brasil, a Educação a Distância, ao longo do tempo, atravessou a era dos Correios, passando pelo rádio e pela televisão, vivendo, hoje, o tempo da internet e provocando, com isso, transformações no campo social, cultural e educacional que afetam diretamente a identidade profissional em todas as áreas. Nesse contexto o presente estudo infere acerca da relação existente entre a Educação a Distância (EaD) e a Identidade Profissional Docente, elencando como problemática de pesquisa o seguinte questionamento: quais as implicações educacionais e pedagógicas incididas sobre a identidade profissional docente, oriundas dos incrementos pedagógicos e docentes da Educação a Distância? O objetivo é, portanto, analisar a relação existente entre o surgimento e a consolidação da EaD no Brasil, seus avanços pedagógicos e a influência da virtualidade na formação de professores. A pesquisa se configura como sendo exploratória, de abordagem qualitativa, de cunho bibliográfico. Os resultados revelam que a EaD se configura como uma modalidade de ensino que demanda práticas educativas, pedagógicas e docentes alinhadas às necessidades provenientes da virtualidade. Evidenciam, ainda, que ela oferece novas oportunidades de desenvolvimento profissional, por fomentar a exploração de novas abordagens tecnológicas e pedagógicas, impactando na reelaboração da identidade docente.
Balanço das contribuições apresentadas nos Congressos Nacionais de Editores de Periódicos de Educação (CONEPEd) para a editoração científica
Authors: Medeiros Neta Olivia , De Oliveira Dias Rosimeri , Imbiriba Sousa Colares Maria Lília
Published: September 2024

Este artigo coloca em análise os Congressos Nacionais de Editores de Periódicos de Educação (CONEPEd) com o objetivo de explicitar a recente trajetória deste Congresso que, em 2024, realiza a sua quarta edição. Eles acontecem como eventos do Fórum de Editores de Periódicos da Área de Educação (FEPAE) da Associação Nacional de Pesquisa e Pós-Graduação em Educação (ANPED) organizado em parceria com a Revista Brasileira de Educação (RBE). Para tanto, uma pesquisa exploratória foi realizada visibilizando o que temos feito nos congressos, suas discussões e contribuições para o presente da editoração de periódicos no Brasil. Foi historicizado nos Congressos Nacionais de Editores de Periódicos de Educação as programações com seus temas, minicursos, eixos temáticos e demais atividades realizadas. Bem como, suas contribuições, redes de apoio, as condições e possibilidades das práticas de publicação e editoração científica na área da educação. É possível dizer que o CONEPEd vem se constituindo como uma possibilidade efetiva de produção de uma rede colaborativa entre editores de periódicos da educação vinculados ao FEPAE/ANPED, assim como espaço de discussão política sobre editoria científica.
O campo editorial e os desafios contemporâneos
Authors: Dias Erika Simone de Almeida Carlos , Jardilino Jos´´e Rubens Lima
Published: September 2024

O objetivo deste ensaio foi refletir sobre os pilares da Ciência Aberta e sua implementação no espaço Ibero-americano. A Ciência Aberta tem sido fundamental para o avanço científico moderno, promovendo colaboração e transparência na pesquisa. Este movimento se insere em um contexto de transformações nas formas de produção e circulação de informação e conhecimento. A Ciência Aberta facilita a rápida divulgação dos resultados de pesquisas, aumentando sua eficiência e impacto. A implementação da Ciência Aberta exige esforços conjuntos de financiadores, instituições e reguladores, transformando profundamente as bases da prática científica e promovendo uma ciência mais colaborativa e eficaz para enfrentar os desafios contemporâneos. No Brasil, a Ciência Aberta enfrenta desafios na comunicação científica, mas, o Brasil não está sozinho, faz parte de um movimento maior que ocorre por toda Ibero América. A implementação do acesso aberto, a internacionalização das revistas, o enfrentamento à mercantilização do conhecimento científico é central para a democratização do conhecimento. A hegemonia do inglês como língua científica impõe barreiras, mas a colaboração regional pode promover uma ciência mais inclusiva. Porém, Iniciativas como DIALNET, REDIB, LATINDEX, SciELO e Redalyc exemplificam os esforços para integrar a ciência ibero-americana às práticas de Ciência Aberta, visando o desenvolvimento sustentável e a justiça social.
Chemical composition, antibacterial, anticancer, and anti-a-glucosidase activities of essential oils from Alpinia nelumboides
Authors: Tran Van Thi Kieu , Le Thang Truong , Nguyen Chuong Hoang , Thi Tran Thao Nguyen , Hoang Viet
Published: September 2024

The chemical composition and biological properties of essential oils extracted from the rhizomes and leaves of Alpinia nelumboides were examined in this study. The oils were isolated via hydrodistillation using a Clevenger apparatus and analyzed with GC-FID/MS. Antibacterial activity against antibiotic-resistant bacterial strains was evaluated using the agar microdilution method. Anticancer and α-glucosidase inhibitory activities were assessed through in vitro assays. Eucalyptol was identified as the major component, accounting for 71.23% and 32.82% of the rhizome and leaves oils, respectively. Both rhizome and leaf extracts exhibited antibacterial activity against several antibiotic-resistant bacterial strains, with minimum inhibitory concentration values ranging from 8 to 16 mg/ ml. The rhizome essential oil demonstrated anticancer properties against NCI-H460 (IC50 = 98.28 ± 5.22 μg/ml) and HepG2 (IC50 = 189.87 ± 3.16 μg/ml) cell lines. Additionally, it showed α-glucosidase inhibitory activity (IC50 = 2.42 mg/ml). The essential oils obtained from A. nelumboides possess promising biological activities, including antibacterial, anticancer, and α-glucosidase inhibitory properties. These findings suggest their potential use as healthcare pharmaceuticals in the future.
Development and Quality Evaluation of Fibre Enriched Broken Basmati Rice Based Noodles
Authors: Bandral Julie D , Sood Monika , Gupta Neeraj , Dutta Upma , Choton Skarma , Chauhan Jesreen
Published: September 2024

Broken rice is fragmented but it cannot be considered as defective because it has same nutritional value as unbroken rice contains. Also, if the broken rice contains all germ and bran, then it has nutrition as brown rice, otherwise it has nutrition as white rice. In the present investigation, protein and fiber rich noodles were prepared by incorporation of groundnut meal (GM) and green leaf powder (GLP) prepared using fenugreek leaves and coriander leaf powder in the ratio 50:50. The quantity of GM and GLP was varied from 0 to 12 and 0 to 18 per cent, respectively for the formulation of rice noodles. The developed products were stored for 90 days in polyethylene bags to ascertain the changes in cooking characteristics, proximate composition and sensory parameters. Weight increase and volume increase showed an increasing trend with the incorporation of green leaf powder and groundnut meal from 142.89 to 183.52 % and 144.73 to 218.98 %, respectively whereas the cooking time and cooking loss significantly decreased from 12.10 to 10.77 minutes and 7.23 to 6.31 per cent, respectively. On the basis of sensory evaluation, noodles prepared from 8 per cent GLP and 12 per cent GM were adjudged the best with regard to their acceptability and storability having mean crude protein, crude fat, crude fibre and ash contents of 17.46, 2.00, 2.17 and 1.01 per cent, respectively.
OB or Not OB: Idiosyncratic utilization of the tRNA‐binding OB‐fold domain in unicellular, pathogenic eukaryotes
Authors: Kapps Delphine , Cela Marta , Théobald‐Dietrich Anne , Hendrickson Tamara , Frugier Magali
Published: October 2016

In this review, we examine the so‐called OB‐fold, a tRNA‐binding domain homologous to the bacterial tRNA‐binding protein Trbp111. We highlight the ability of OB‐fold homologs to bind tRNA species and summarize their distribution in evolution. Nature has capitalized on the advantageous effects acquired when an OB‐fold domain binds to tRNA by evolutionarily selecting this domain for fusion to different enzymes. Here, we review our current understanding of how the complexity of OB‐fold‐containing proteins and enzymes developed to expand their functions, especially in unicellular, pathogenic eukaryotes.
miR‐296 inhibits proliferation and induces apoptosis by targeting FGFR1 in human hepatocellular carcinoma
Authors: Wang Liyan , Bo Xiaotong , Zheng Qinghua , Xiao Xuhua , Wu Linling , Li Bin
Published: October 2016

MiR‐296 was previously reported to be underexpressed in hepatocellular carcinoma (HCC). However, the clinical value of miR‐296 and its function in HCC remain poorly understood. In this study, we found that miR‐296 levels are decreased in HCC specimens and cells, and that the underexpression of miR‐296 is associated with adverse clinical parameters and poor overall survival rate. In vitro experiments indicate that miR‐296 inhibits proliferation, colony formation, and cell cycle progression, and enhances apoptosis in HCC cells. Notably, we found that the fibroblast growth factor receptor 1 (FGFR1) is a downstream target that mediates the functions of miR‐296 in HCC. Thus, our findings indicate that miR‐296 exerts a tumor suppressive role in HCC and is a potential biomarker and drug‐target.
TIM29 is a subunit of the human carrier translocase required for protein transport
Authors: Callegari Sylvie , Richter Frank , Chojnacka Katarzyna , Jans Daniel C. , Lorenzi Isotta , Pacheu‐Grau David , Jakobs Stefan , Lenz Christof , Urlaub Henning , Dudek Jan , Chacinska Agnieszka , Rehling Peter
Published: October 2016

Hydrophobic inner mitochondrial membrane proteins with internal targeting signals, such as the metabolite carriers, use the carrier translocase (TIM22 complex) for transport into the inner membrane. Defects in this transport pathway have been associated with neurodegenerative disorders. While the TIM22 complex is well studied in baker's yeast, very little is known about the mammalian TIM22 complex. Using immunoprecipitation, we purified the human carrier translocase and identified a mitochondrial inner membrane protein TIM29 as a novel component, specific to metazoa. We show that TIM29 is a constituent of the 440 kDa TIM22 complex and interacts with oxidized TIM22. Our analyses demonstrate that TIM29 is required for the structural integrity of the TIM22 complex and for import of substrate proteins by the carrier translocase.
First paleoseismic evidence for great surface‐rupturing earthquakes in the Bhutan Himalayas
Authors: Le Roux‐Mallouf Romain , Ferry Matthieu , Ritz Jean‐François , Berthet Théo , Cattin Rodolphe , Drukpa Dowchu
Published: October 2016

The seismic behavior of the Himalayan arc between central Nepal and Arunachal Pradesh remains poorly understood due to the lack of observations concerning the timing and size of past major and great earthquakes in Bhutan. We present here the first paleoseismic study along the Himalayan topographic front conducted at two sites in southern central Bhutan. Paleoseismological excavations and related OxCal modeling reveal that Bhutan experienced at least two great earthquakes in the last millennium: one between the seventeenth and eighteenth century and one during medieval times, producing a total cumulative vertical offset greater than 10 m. Along with previous studies that reported similar medieval events in Central Nepal, Sikkim, and Assam, our investigations support the occurrence of either (i) a series of great earthquakes between A.D. 1025 and A.D. 1520 or (ii) a single giant earthquake between A.D. 1090 and A.D. 1145. In the latter case, the surface rupture may have reached a total length of ~800 km and could be associated with an earthquake of magnitudeMw = 8.7–9.1.
Resolving a long‐standing model‐observation discrepancy on ozone solar cycle response
Authors: Li King‐Fai , Zhang Qiong , Tung Ka‐Kit , Yung Yuk L.
Published: October 2016

To have the capability for long‐term prediction of stratospheric ozone (O3), chemistry‐climate models have often been tested against observations on decadal timescales. A model‐observation discrepancy in the tropical O3 response to the 11 year solar cycle, first noted in 1993, persists for more than 20 years: While standard photochemical models predict a single‐peak response in the stratosphere, satellite observations show an unexpected double‐peak structure. Such discrepancy has led to the question of whether the current standard O3 photochemistry is deficient. Various studies have explored uncertainties in photochemistry and dynamics but there has not been compelling evidence of model biases. Here we suggest that decadal satellite orbital drifts relative to the diurnal cycle could be the primary cause of the discrepancy. We show that the double‐peak structure can be reproduced by adding the A.M./P.M. diurnal difference to the single‐peak response predicted by the standard photochemistry. Thus we argue that the standard photochemistry is consistent with the observed solar cycle modulation in stratospheric O3.
Magnetic and geochemical signatures of flood layers in a lake system
Authors: Støren Eivind W. N. , Paasche Øyvind , Hirt Ann M. , Kumari Monika
Published: October 2016

River floods holds the capasity to erode and transport sediments that are deposited whenever the discharge is reduced. In catchments that are subjected to repeated flooding, downstream lakes can therefore contain a record of past events across multiple timescales. High‐resolution core scanning analyses, such as X‐ray fluorescence (XRF) scanning and magnetic susceptibility (MS) provide data that are frequently used to detect flood layers in soft sediment archives, such as lakes, fjords and ocean basins. Deposits of past floods also can potentially reveal information about the evolution of flood events as well as source area. Here we explore ways in which subtle variability in high‐resolution data can be utilized and subsequently vetted by high‐precision measurements in order to delineate the copious information that can be extracted from soft sediment records. By combining magnetic hysteresis measurements and first‐order reversal curves (FORCs) with inductively coupled plasma optical emission spectrometer (ICP‐OES) measurements of chemical elements on 36 samples, questions about flood dynamics and variability are raised, and also sources of noise in high‐resolution scanning techniques are discussed. Specifically, we show that a lake flood record from Southern Norway containing 92 floods distributed over 10,000 years can be subdivided into two groups of floods that were generated either by spring snow melting, intense summer rainstorms, or a combination of both. The temporal evolution of this pattern shows a marked shift toward spring floods around 2000 years ago compared to the earlier part of the record.
Effects of the crustal magnetic fields on the Martian atmospheric ion escape rate
Authors: Ramstad Robin , Barabash Stas , Futaana Yoshifumi , Nilsson Hans , Holmström Mats
Published: October 2016

Eight years (2007–2015) of ion flux measurements from Mars Express are used to statistically investigate the influence of the Martian magnetic crustal fields on the atmospheric ion escape rate. We combine all Analyzer of Space Plasmas and Energetic Atoms/Ion Mass Analyzer (ASPERA‐3/IMA) measurements taken during nominal upstream solar wind and solar extreme ultraviolet conditions to compute global average ion distribution functions, individually for the north/south hemispheres and for varying solar zenith angles (SZAs) of the strongest crustal magnetic field. Escape rates are subsequently calculated from each of the average distribution functions. The maximum escape rate (4.2 ± 1.2) × 1024s−1 is found for SZA = 60°–80°, while the minimum escape rate (1.7 ± 0.6) × 1024s−1 is found for SZA = 28°–60°, showing that the dayside orientation of the crustal fields significantly affects the global escape rate (p = 97%). However, averaged over time, independent of SZA, we find no statistically significant difference in the escape rates from the two hemispheres (escape from southern hemisphere 46% ± 18% of global rate).
Trends in annual and extreme flows in the Lena River basin, Northern Eurasia
Authors: Tananaev N. I. , Makarieva O. M. , Lebedeva L. S.
Published: October 2016

A long‐term daily streamflow data set, covering the period from 1925 to 2013, was compiled for the Lena River basin, with an average record length of 49 years. Time series of mean annual daily flow (MADF) and extreme (maximum,Qmax, and minimum,Qmin) daily flows were subject to trend detection and change point detection analysis. Significant changes result mostly from rapid “breakpoint” homogeneity disruptions. Thirty one time series showed trends in MADF, 10, inQmax, and 32 of the 55 records with nonzeroQmin, significant atp ≤ 0.05. Upward trends prevail in both mean annual and extreme flows, with average magnitudes of 47% (MADF), 56% (Qmax), and 68% (Qmin). Two to three stations in each subset showed downward trends (averaging −20%, −39%, and −38%, respectively). Abrupt changes are observed in the 1990s and early 2000s mostly in the headwaters of the basin, underlain by discontinuous permafrost.