bluuebunny/crossref_metadata_2025 huggingface dataset:
Administration of Asian Herb Bennet (Geum japonicum) Extract Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone
Authors: Lim Dong Wook , Han Taewon , Um Min Young , Yoon Minseok , Kim Tae-Eun , Kim Yun Tai , Han Daeseok , Lee Jaekwang , Lee Chang Ho
Published: November 2019

Geum japonicum, commonly known as Asian herb bennet, has been used as a diuretic, astringent, anti-dizziness, and anti-headache agent in traditional medicine. Since the antidepressant-like effects of G. japonicum extract have not been well studied, we examined the antidepressant-like effects of G. japonicum extract using depressive-like behavior induced in mice through daily injection of corticosterone (CORT). ICR mice (male, 8 weeks old) were treated with CORT (40 mg/kg, i.p.) and orally administered using oral gavage needles with G. japonicum extract (30, 100, and 300 mg/kg) for 4 weeks. Behavioral experiments were performed 1 h after administration. The control mice exhibited a significant increase in the immobility times in the tail suspension and forced swim tests as well as the step-through latency time in the passive avoidance test. Further, the control group showed a significant decrease in their sucrose consumption. However, treatment with G. japonicum extract at doses of 100 and 300 mg/kg significantly improved these depression-like behaviors without altering the locomotor activity. Moreover, treatment with G. japonicum extract significantly prevented the decrease in the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. In addition, G. japonicum extract had neuroprotective effects against CORT-induced neurotoxicity in SH-SY5Y cells. Our study indicates that G. japonicum extract exhibits antidepressant-like activity in CORT-induced depressive mice, which might be as a result of increased BDNF expression.
Withaninsams A and B: Phenylpropanoid Esters from the Roots of Indian Ginseng (Withania somnifera)
Authors: Baek Su Cheol , Lee Seoyoung , Kim Sil , Jo Mun Seok , Yu Jae Sik , Ko Yoon-Joo , Cho Young-Chang , Kim Ki Hyun
Published: November 2019

Withania somnifera (L.) Dunal (Solanaceae), known as Indian ginseng or ashwagandha, has been used in Indian Ayurveda for the treatment of a variety of disorders, such as diabetes and reproductive and nervous system disorders. It is particularly used as a general health tonic, analgesic, and sedative. As part of continuing projects to discover unique bioactive natural products from medicinal plants, phytochemical investigation of the roots of W. somnifera combined with a liquid chromatography–mass spectrometry (LC/MS)-based analysis has led to the isolation of two novel phenylpropanoid esters, Withaninsams A (1) and B (2), as an inseparable mixture, along with three known phenolic compounds (3, 4, and 6) and a pyrazole alkaloid (5). The structures of the new compounds were elucidated using a combination of spectroscopic methods, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HR-ESIMS). Withaninsams A (1) and B (2) are phenylpropanoid esters that contain a side chain, 4-methyl-1,4-pentanediol unit. To the best of our knowledge, the present study is the first to report on phenylpropanoid esters with 4-methyl-1,4-pentanediol unit. The anti-inflammatory activity of the isolated compounds (1–6) was evaluated by determining their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, where compound 3 inhibited LPS-induced NO production (IC50 = 33.3 μM) and TNF-α production, a pro-inflammatory cytokine (IC50 = 40.9 μM). The anti-inflammatory mechanism through the inhibition of transcriptional iNOS protein expression was confirmed by western blotting experiments for the active compound 3, which showed decreased iNOS protein expression.
The Role of MicroRNAs in Genome Response to Plant–Lepidoptera Interaction
Authors: Ražná Katarína , Cagáň Ľudovít
Published: November 2019

RNA interference is a known phenomenon of plant immune responses, involving the regulation of gene expression. The key components triggering the silencing of targeted sequences are double-stranded RNA molecules. The regulation of host–pathogen interactions is controlled by miRNA molecules, which regulate the expression of host resistance genes or the genes of the pathogen. The review focused on basic principles of RNA interference as a gene-silencing-based defense mechanism and the role of miRNA molecules in insect genomes. RNA interference as a tool for plant protection management is discussed. The review summarizes current miRNA-based biotechnology approaches for plant protection management.
Synthesis of Bisphenol A Based Phosphazene-Containing Epoxy Resin with Reduced Viscosity
Authors: Kireev Vyacheslav V. , Bilichenko Yulya V. , Borisov Roman S. , Mu Jianxin , Kuznetsov Dmitry A. , Eroshenko Anastasiya V. , Filatov Sergey N. , Sirotin Igor S.
Published: November 2019

Phosphazene-containing epoxy oligomers (PEO) were synthesized by the interaction of hexachlorocyclotriphosphazene (HCP), phenol, and bisphenol A in a medium of excess of epichlorohydrin using potassium carbonate and hydroxide as HCl acceptors with the aim of obtaining a product with lower viscosity and higher phosphazene content. PEOs are mixtures of epoxycyclophosphazene (ECP) and a conventional organic epoxy resin based on bisphenol A in an amount controlled by the ratio of the initial mono- and diphenol. According to 31P NMR spectroscopy, pentasubstituted aryloxycyclotrophosphazene compounds predominate in the ECP composition. The relative content in the ECP radicals of mono- and diphenol was determined by the MALDI-TOF mass spectrometry method. The organic epoxy fraction, according to gas chromatograpy-mass spectrometry (GC-MS), contains 50–70 wt % diglycidyl ether of bisphenol A. PEO resins obtained in the present work have reduced viscosity when compared to other known phosphazene-containging epoxy resins while phosphazene content is still about 50 wt %. Resins with an epoxy number within 12–17 wt %, are cured by conventional curing agents to form compositions with flame-retardant properties, while other characteristics of these compositions are at the level of conventional epoxy materials.
Enhancing the Efficacy of Religious Peacebuilding Practice: An Exploratory Evidence-Based Framework for Assessing Dominant Risks in Religious Peacebuilding
Authors: Owen Mark , King Anna
Published: November 2019

The ‘risk assessment’ in peacebuilding has become a standard, if sometimes slightly formulaic and performative, element of project design and written proposals. Largely driven by donor requirements and organisational procedures, the relatively new discipline and practice recognised as ‘Religious Peacebuilding’ has taken on many of the elements of ‘secular’ peacebuilding, including the risk assessment. This means that organisations increasingly have to attempt to understand the associated risks to projects with a religious dimension often without any specific guidelines, and in many cases, any relevant knowledge or previous experience of working with religious actors in peacebuilding. Consequently, the primary objective of this paper is to propose the first risk assessment framework for peacebuilding projects which explicitly focus on religious dimensions and actors. The framework is based on analysis of case studies and project evaluations from a number of contexts; and has the potential to make a tangible difference to the efficacy and impact of peacebuilding projects in a variety of post-conflict contexts. This paper will also briefly consider how the proposed framework relates to contemporary theoretical debates concerning the instrumentalization of religion, and increasing technocracy in peacebuilding theory and practice.
Creating Social Handprints: Method and Case Study in the Electronic Computer Manufacturing Industry
Authors: Benoit Norris Catherine , Norris Gregory A. , Azuero Lina , Pflueger John
Published: November 2019

This article introduces a process that can be used by companies to obtain an increasingly precise picture of their supply chain social footprint (negative impacts) and identify potential social handprints (i.e., changes to business as usual that create positive impacts) using social organizational life cycle assessment (SO-LCA). The process was developed to apply to the electronics sector but can be used by companies in any industry. Our case study presents the social footprint of a typical US computer manufacturing company and identifies potential salient social risks and hotspots using generic information about the inputs that are related to a global trade model. The global trade model enables us to map the likely supply chain based on where inputs are usually sourced from by the US electronic computer manufacturing sector. In order to identify material impacts, normalization factors were created and used. Once the material impacts and salient risks are known, it becomes necessary to identify root causes in order to plan actions that will truly make a meaningful change, addressing the issues at stake. The article concludes by establishing a methodology that enables the use of the industry-level impacts and assessment in combination with the organization’s own data to calculate company-specific results.
The Optimal Threshold and Vegetation Index Time Series for Retrieving Crop Phenology Based on a Modified Dynamic Threshold Method
Authors: Huang Xin , Liu Jianhong , Zhu Wenquan , Atzberger Clement , Liu Qiufeng
Published: November 2019

Crop phenology is an important parameter for crop growth monitoring, yield prediction, and growth simulation. The dynamic threshold method is widely used to retrieve vegetation phenology from remotely sensed vegetation index time series. However, crop growth is not only driven by natural conditions, but also modified through field management activities. Complicated planting patterns, such as multiple cropping, makes the vegetation index dynamics less symmetrical. These impacts are not considered in current approaches for crop phenology retrieval based on the dynamic threshold method. Thus, this paper aimed to (1) investigate the optimal thresholds for retrieving the start of the season (SOS) and the end of the season (EOS) of different crops, and (2) compare the performances of the Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI) in retrieving crop phenology with a modified version of the dynamic threshold method. The reference data included SOS and EOS ground observations of three major crop types in 2015 and 2016, which includes rice, wheat, and maize. Results show that (1) the modification of the original method ensures a 100% retrieval rate, which was not guaranteed using the original method. The modified dynamic threshold method is more suitable to retrieve crop SOS/EOS because it considers the asymmetry of crop vegetation index time series. (2) It is inappropriate to retrieve SOS and EOS with the same threshold for all crops, and the commonly used 20% or 50% thresholds are not the optimal thresholds for all crops. (3) For single and late rice, the accuracies of the SOS estimations based on EVI are generally higher compared to those based on NDVI. However, for spring maize and summer maize, results based on NDVI give higher accuracies. In terms of EOS, for early rice and summer maize, estimates based on EVI result in higher accuracies, but, for late rice and winter wheat, results based on NDVI are closer to the ground records.
An Efficient Encoding Voxel-Based Segmentation (EVBS) Algorithm Based on Fast Adjacent Voxel Search for Point Cloud Plane Segmentation
Authors: Huang Ming , Wei Pengcheng , Liu Xianglei
Published: November 2019

Plane segmentation is a basic yet important process in light detection and ranging (LiDAR) point cloud processing. The traditional point cloud plane segmentation algorithm is typically affected by the number of point clouds and the noise data, which results in slow segmentation efficiency and poor segmentation effect. Hence, an efficient encoding voxel-based segmentation (EVBS) algorithm based on a fast adjacent voxel search is proposed in this study. First, a binary octree algorithm is proposed to construct the voxel as the segmentation object and code the voxel, which can compute voxel features quickly and accurately. Second, a voxel-based region growing algorithm is proposed to cluster the corresponding voxel to perform the initial point cloud segmentation, which can improve the rationality of seed selection. Finally, a refining point method is proposed to solve the problem of under-segmentation in unlabeled voxels by judging the relationship between the points and the segmented plane. Experimental results demonstrate that the proposed algorithm is better than the traditional algorithm in terms of computation time, extraction accuracy, and recall rate.
A Fast, Three-Dimensional, Indirect Geolocation Method Using IAGM and DSM Data without GCPs for Spaceborne SAR Images
Authors: Liu Min , Xiao Peng
Published: November 2019

To determine the geolocation of a pixel for spaceborne synthetic aperture radar (SAR) images, traditional indirect geolocation methods can cause great computational complexity. In this paper, a fast, three-dimensional, indirect geolocation method without ground control points (GCPs) is presented. First, the Range-Doppler (RD) geolocation model with all the equations in the Earth-centered rotating (ECR) coordinate system is introduced. By using an iterative analytical geolocation method (IAGM), the corner point locations of a quadrangle SAR image on the Earth’s surface are obtained. Then, a three-dimensional (3D) grid can be built by utilizing the digital surface model (DSM) data in this quadrangle. Through the proportional relationship for every pixel in the 3D grid, the azimuth time can be estimated, which is the key to decreasing the calculation time of the Doppler centroid. The results show that the proposed method is about 12 times faster than the traditional method, and that it maintains geolocation accuracy. After acquiring the precise azimuth time, it is easy to obtain the range location. Therefore, the spaceborne SAR image can be geolocated to the Earth surface precisely based on the high-resolution DSM data.
A Single-Chip High-Voltage Integrated Actuator for Biomedical Ultrasound Scanners
Authors: Hsia Chin , Hsiao Yi-Chi , Huang Yen-Chung
Published: November 2019

This article presents a high-voltage (HV) pulse driver based on silicon-on-insulator (SOI) technology for biomedical ultrasound actuators and multi-channel portable imaging systems specifically. The pulse driver, which receives an external low-voltage drive signal and produces high-voltage pulses with a balanced rising and falling edge, is designed by synthesizing high-speed, capacitor-coupled level-shifters with a high-voltage H-bridge output stage. In addition, an on-chip floating power supply has also been developed to simplify powering the entire system and reduce static power consumption. The electrical and acoustic performance of the integrated eight-channel pulse driver has been verified by using medical-grade ultrasound probes to acquire the transmit/echo signals. The driver can produce pulse signals >100 Vpp with rise and fall times within 18.6 and 18.5 ns, respectively. The static power required to support the overall system is less than 3.6 mW, and the power consumption of the system during excitation is less than 50 mW per channel. The second harmonic distortion of the output pulse signal is as low as −40 dBc, indicating that the integrated multi-channel pulse driver can be used in advanced portable ultrasonic imaging systems.
A Gyroscope Signal Denoising Method Based on Empirical Mode Decomposition and Signal Reconstruction
Authors: Liu Chenchen , Yang Zhiqiang , Shi Zhen , Ma Ji , Cao Jian
Published: November 2019

To suppress the random drift error of a gyroscope signal, this paper proposes a novel denoising method, which is based on processing the intrinsic mode functions (IMFs) obtained by empirical mode decomposition (EMD). Considering that a gyroscope signal contains colored noise in addition to Gaussian white noise, fractal Gaussian noise (FGN) was introduced to quantify the noise in the gyroscope data. The proposed denoising method combines the FGN energy model and the modified method of Hausdorff distance (HD) to adaptively divide the IMFs into three categories (pure noise, pure information, and mixed components of noise and information). Then, the information IMFs and the mixed components after thresholding were selected to give the optimal signal reconstruction. Static and dynamic signal tests of the fiber optic gyroscope (FOG) were carried out to illustrate the performance of the proposed method, and compared with other traditional EMD denoising methods, such as the Euclidean norm measure method (EMD- l 2 -norm) and the sliding average filtering method (EMD-SA). The results of the analysis of both the static and dynamic signal tests indicate the effectiveness of the proposed method.
A Multiobjective, Lion Mating Optimization Inspired Routing Protocol for Wireless Body Area Sensor Network Based Healthcare Applications
Authors: Faheem Muhammad , Butt Rizwan Aslam , Raza Basit , Alquhayz Hani , Abbas Muhammad Zahid , Ngadi Md Asri , Gungor Vehbi Cagri
Published: November 2019

The importance of body area sensor networks (BASNs) is increasing day by day because of their increasing use in Internet of things (IoT)-enabled healthcare application services. They help humans in improving their quality of life by continuously monitoring various vital signs through biosensors strategically placed on the human body. However, BASNs face serious challenges, in terms of the short life span of their batteries and unreliable data transmission, because of the highly unstable and unpredictable channel conditions of tiny biosensors located on the human body. These factors may result in poor data gathering quality in BASNs. Therefore, a more reliable data transmission mechanism is greatly needed in order to gather quality data in BASN-based healthcare applications. Therefore, this study proposes a novel, multiobjective, lion mating optimization inspired routing protocol, called self-organizing multiobjective routing protocol (SARP), for BASN-based IoT healthcare applications. The proposed routing scheme significantly reduces local search problems and finds the best dynamic cluster-based routing solutions between the source and destination in BASNs. Thus, it significantly improves the overall packet delivery rate, residual energy, and throughput with reduced latency and packet error rates in BASNs. Extensive simulation results validate the performance of our proposed SARP scheme against the existing routing protocols in terms of the packet delivery ratio, latency, packet error rate, throughput, and energy efficiency for BASN-based health monitoring applications.
Application of Raman Spectroscopy to Working Gas Sensors: From in situ to operando Studies
Authors: Elger Ann-Kathrin , Hess Christian
Published: November 2019

Understanding the mode of operation of gas sensors is of great scientific and economic interest. A knowledge-based approach requires the development and application of spectroscopic tools to monitor the relevant surface and bulk processes under working conditions (operando approach). In this review we trace the development of vibrational Raman spectroscopy applied to metal-oxide gas sensors, starting from initial applications to very recent operando spectroscopic approaches. We highlight the potential of Raman spectroscopy for molecular-level characterization of metal-oxide gas sensors to reveal important mechanistic information, as well as its versatility regarding the design of in situ/operando cells and the combination with other techniques. We conclude with an outlook on potential future developments.
Normative Environmental Configuration of SMEs within the Sustainable Development Discourse in South Africa: An Empirical Study
Authors: Masocha Reginald
Published: November 2019

This paper investigates the role of normative environmental configuration forces on small and medium-sized enterprises (SMEs) adopting sustainable development practices in South Africa. A research survey was performed, and data were gathered from SMEs utilizing owners and managers as respondents. Non-probability sampling at the hand of the convenience method was utilised and 220 respondents constituted the final sample. The analysis of data constituted factor analysis and hypotheses were tested through the structural equation modelling technique. The study hypothesised that normative forces have an impact on the participation of SMEs in the extents of sustainability practices, namely social, environmental and economic. The results led to the supporting of all the hypotheses postulated in the study. Thus, the major recommendation was to support the training, networking and professional affiliations of SMEs in sustainable development issues in order to ensure proliferation of sustainable development amongst these firms.
Bio-Inspired Synthetic Ivory as a Sustainable Material for Piano Keys
Authors: Fischer Dieter , Parks Sarah C. , Mannhart Jochen
Published: November 2019

Natural ivory is no longer readily or legally available, as it is obtained primarily from elephant tusks, which now enjoy international protection. Ivory, however, is the best material known for piano keys. We present a hydroxylapatite–gelatin biocomposite that is chemically identical to natural ivory but with functional properties optimized to replace it. As this biocomposite is fabricated from abundant materials in an environmentally friendly process and is furthermore biodegradable, it is a sustainable solution for piano keys with the ideal functional properties of natural ivory.
Assessing the Moderating Effect of Corruption on the E-Government and Trust Relationship: An Evidence of an Emerging Economy
Authors: Jameel Arif , Asif Muhammad , Hussain Abid , Hwang Jinsoo , Sahito Noman , Bukhari Mussawar Hussain
Published: November 2019

The foremost purpose of this article is to investigate the effect of electronic-government (e-government) on public trust and the moderating impact of corruption on this relationship. The data was obtained through a structural questionnaire involving 800 Pakistani citizens at the local level. The true response rate was 58.3%. The data was analyzed using confirmatory factor analysis, multiple regression and stepwise hierarchal regression. The results showed there is an empirically significant association among e-government practices and public trust in local self-government and a negative moderating role of corruption. The findings suggest that e-government can develop a procedure-based trust by advancing connections with people and their insights of responsiveness. The individuals’ viewpoints about the state, including trust, are fundamental concerns for the governance and administrative system. Testing these above associations via a moderation technique is a novel process which contributed to the current study on e-government.
Identification of Urban Functional Regions Based on Floating Car Track Data and POI Data
Authors: Yu Beibei , Wang Zhonghui , Mu Haowei , Sun Li , Hu Fengning
Published: November 2019

Along with the rapid development of China’s economy as well as the continuing urbanization, the internal spatial and functional structures of cities within this country are also gradually changing and restructuring. The study of functional region identification of a city is of great significance to the city’s functional cognition, spatial planning, economic development, human livability, and so forth. Backed by the emerging urban Big Data, and taking the traffic community as the smallest research unit, a method is proposed to identify urban functional regions by combining floating car track data with point of interest (POI) data recorded on an electronic map. It provides a new perspective for the study of urban functional region identification. Firstly, the main functional regions of the city studied are identified through clustering analysis according to the passenger’s spatial-temporal travel characteristics derived from the floating car data. Secondly, the fine-grained identification of the functional region attributes of the traffic communities is achieved using the label information from POI data. Finally, the AND-OR operation is performed on the recognition results derived by the clustering algorithm and the Delphi method, to obtain the identification of urban functional regions. This approach is verified by applying it to the main urban zone within Chengdu’s Third Ring Road. The results show that: (1) There are fewer single functional regions and more mixed functional regions in the main urban zone of Chengdu, and the distribution of the functional regions are roughly concentric centering in the city center. (2) Using the traffic community as a research unit, combined with dynamic human activity trajectory data and static urban interest point data, complex urban functional regions can be effectively identified.
Effect of Biochar and Irrigation on the Interrelationships among Soybean Growth, Root Nodulation, Plant P Uptake, and Soil Nutrients in a Sandy Field
Authors: Ma Hua , Egamberdieva Dilfuza , Wirth Stephan , Li Qirui , Omari Richard Ansong , Hou Mudan , Bellingrath-Kimura Sonoko D.
Published: November 2019

To investigate the interrelationships among biochar, soil nutrients, and soybean plant growth in more detail, the root nodulation response of soybean (Glycine max L.) to biochar application was analyzed in a field study. We further examined the biochar effect on soil phosphatase activity to elucidate the relationships among biochar, phosphatase activity, and plant phosphorus uptake. Soybean was planted in a sandy field wherein the biochar and irrigation conditions were considered the two treatment factors. In our result, irrigation increased the pod number and plant height by 20.7% and 11.1%, respectively. Irrigation reduced the shoot and root dry matter content by 67.9% and 75.1%, respectively. The nodule number increased by 37% due to biochar addition under irrigated conditions. The soil carbon concentration was elevated by 13.4% with biochar application under rainfed conditions. Acid phosphomonoesterase (APM) was increased by 21.8% in the biochar-incorporated plots under the irrigated condition. Principal component analysis and redundancy analysis suggested that biochar application enhanced the relationships between the nodule number and soil potassium and magnesium concentrations. The correlation between soil sulfur content and nodule number was eliminated by biochar application. APM activity was associated with higher shoot and root phosphorus content and shoot dry weight after biochar application.
The Improvement of the Comfort of Public Spaces as a Local Initiative in Coping with Climate Change
Authors: Vukmirovic Milena , Gavrilovic Suzana , Stojanovic Dalibor
Published: November 2019

Being the vital element of successful cities, public spaces play an important role in achieving sustainable development goals and in coping with climate change. The new urban agenda considers public spaces indispensable for sustaining the productivity of cities, social cohesion and inclusion, civic identity, and quality of life. Accordingly, there is no doubt about the importance of public spaces, while their quality is generated through the symbiosis of various elements. On the basis of normative theories of urban design, several public space design frameworks have been established in order to define what makes a good public place. Such a framework for public space quality evaluation is developed and tested at the Chair for Planning and Design in Landscape Architecture at the University of Belgrade—Faculty of Forestry. The framework covers six criteria which illuminate key aspects of public spaces: safety and security, accessibility, legibility, comfort, inspiration and sensitivity and liveability. In this research, special attention is paid to the criteria of comfort analysed on two scale levels in Belgrade, Serbia. In the past, Belgrade was affected by extreme weather events that caused serious and sometimes disastrous consequences. The most pronounced challenges among them are heat waves in summer that, due to the shortage of vegetation combined with the proliferation of tarmac and concrete surfaces and reduced air ventilation, particularly threaten the densely populated central municipalities of Stari Grad, Savski Venac and Vracar. The first scale level covers the analysis of the public space network and the degree of establishment of green infrastructure in Lower Dorcol quartier, which is located in the Municipality of Stari Grad, using quantitative and qualitative indicators and GIS (Geographic Information System) digital tools. The aim of this study is to observe the actual state of the public space network and to define a future scenario of its development in line with climate change challenges. Jevrejska Street, as an element of the above-mentioned public space network, is the subject of the next phase of the research. The study on this scale level will cover qualitative and quantitative analysis of public space elements such as paving, urban equipment, greenery, lighting, water facilities, etc. Next to that, by using the ENVI Met platform, the actual and proposed improvement of the street will be explored. The final part of this research will include a discussion about the research methodology used in order to improve the public space design process and to point out the need for the careful consideration of comfort as an important aspect of good public space.
The Impact of Financial Leverage on Shareholders’ Systematic Risk
Authors: Aharon David Yechiam , Yagil Yossi
Published: November 2019

This paper tests the degree to which a sustainable relationship exists between financial leverage and the systematic risk of shareholders under the following capital market imperfections: corporate and personal taxes as well as risky debt and bankruptcy costs. This beta-leverage relationship has not yet been examined empirically in prior studies nor compared with the theoretical parameter values implied by well-known formulations in the literature. Using data from publicly traded American industrial firms, we found that risky debt models, rather than their corresponding risk free debt models, are more sustainable and appropriate for describing the link between equity beta and financial leverage. Our findings imply that estimating betas or unlevering betas based on risk free debt models might lead to unsustainable and inaccurate estimates of key corporate parameters such as the cost of capital, and may consequently lead to inappropriate capital budgeting decisions. In this respect, the results of this study might have consequences to the recently growing area of sustainable finance in the sense that investment decisions made by different bodies and institutions in the country are more consistent with market imperfections that exist in the economy. In other words, our findings can be in line with a sustainable financial marketplace that contributes to the economic efficiency in the long run and can be related to social well-being.
Social Parking: Applying the Citizens as Sensors Paradigm to Parking Guidance and Information
Authors: Barbancho Julio , Ropero Jorge , Luque Joaquín , Caraballo Alejandro , León Carlos
Published: November 2019

Nowadays, the problem of parking guidance information (PGI) is one of the great challenges of smart cities. Sensor networks have been traditionally used, but they sometimes constitute a high administrative cost. For this reason, this paper presents social parking, a system that is based on the citizens as sensors paradigm, where data are collected by users and are processed using data mining techniques. Moreover, an ontology is used to enable the standardization of information. This way, social parking is compatible with the FIWARE platform. A forecast algorithm was also designed and verified to estimate the number of free parking spots inside a parking lot. With this aim, we used public parking data from eight parking lots in the city of Zaragoza. Client applications allowed testing of all the functions of the parking system. These tests were carried out in three experimental parking lots in the city of Málaga.
Stakeholders and Long-Term Sustainability of SMEs. Who Really Matters in Crisis Contexts, and When
Authors: Manzaneque-Lizano Montserrat , Alfaro-Cortés Esteban , Priego de la Cruz Alba María
Published: November 2019

The impact of crises on the long-term sustainability of small and medium-sized enterprises (SMEs) has been attracting growing interest in the literature and from governments due to the significance of such companies with respect to economic growth, innovation, and employment. Although failure prediction models have been proposed based on accounting and other qualitative information, little is known regarding the influence of stakeholders on the failure process of SMEs. From the perspective of long-term sustainability, this article analyzes the role of the financial influence of stakeholders on the likelihood of business failure. An empirical study was carried out on a sample of 2352 Spanish SMEs, examining the differences between failed and non-failed SMEs and using a classification tree methodology to investigate the role played by each type of stakeholder in overcoming crisis events. The study provides empirical evidence regarding the relative importance of stakeholders to SMEs under conditions of financial distress, and proposes their categorization on the basis of their control over firms’ financial resources. Specifically, the analysis reveals that the capacity of the firm to generate sustainable wealth over time and to overcome critical situations is dependent on the most critical stakeholders. Workers, customers, and suppliers are the most important in ensuring the long-term sustainability of SMEs during the first stages of a crisis. Following the initial operational problems, other creditors (financial institutions) become relevant. In this sense, the results of this study encourage firms and governments to develop cooperation strategies with stakeholders (co-responsibility) in line with the proposed conceptual models of business sustainability.
Developing a Digital Artifact for the Sustainable Presentation of Marketing Research Results
Authors: Shen Zheng , de la Garza Armida
Published: November 2019

The rapid development of technology transforms the way researchers conduct projects, communicate with others, and disseminate findings. In addition to traditional presentations of research results, this paper argues that building a digital artifact is another optional method for the dissemination of research findings from the perspective of marketing. Thus, 20 Irish and Chinese micro-influencers were investigated from March 2016 to March 2019, and their microblogs were analyzed by text mining techniques. Consequently, the paper finds four types of keywords that micro-influencers apply to their marketing on social media. Based on the marketing keywords, a digital tool is designed to label fashion keywords in the microblogging automatically. The proposed tool not only contributes to model fashion bloggers’ content and increase the influence of marketing on social media but also enlightens marketing scholars to develop digital tools for the sustainability of disseminating research results.
The Evolutionary Use of Curved Wood in Korean Traditional Architecture
Authors: Ryoo Seong Lyong , Youn Hyun Chul
Published: November 2019

Various types of curved wooden have always been used in traditional Korean architecture. One component is a curvaceous column with varying thicknesses, and the others are curved beams or girders that are needed to support the roof and present diverse curvature. By examining the historical alteration of the parts and shapes of these curved members, it is possible to identify the sustainable aspects of Korean traditional architecture and infer the influence of the historical background on forming the sustainability of the architecture. To be specific, while the Goryeo Dynasty (10–14 C) showed an aesthetic summit of temple architecture in terms of extravagant curved wooden members precisely calculated and designed under the influence of Buddhism and aristocracy, the early Joseon Dynasty (15–16 C) presented restrained curve forms of wooden members with fewer materials and a faster process due to Neo-Confucianism, which emphasized austerity. After tremendous social crisis and two wars, the mid-Joseon Dynasty (17–18 C) showed creative indigenous houses with naturally curved timbers, minimizing the manufacturing process and maximizing the pragmatic functionality of the space under the influence of the wars and Silhak (the Realist School of Confucianism). In addition, the late Joseon Dynasty (19–20 C) presented office buildings with strengthened dynamic shapes of the naturally curved timbers as symbolic expression, which is an expanded concept beyond the functionality. In Korean traditional architecture, curved wood members have been used without interruption—although in varying degrees depending on social and economic situations—and have continued to be one of the characteristics of Korean architecture.
Estimation and Climate Factor Contribution of Aboveground Biomass in Inner Mongolia’s Typical/Desert Steppes
Authors: Wang Xiumei , Dong Jianjun , Baoyin Taogetao , Bao Yuhai
Published: November 2019

Grassland biomass is an essential part of the regional carbon cycle. Rapid and accurate estimation of grassland biomass is a hot topic in research on grassland ecosystems. This study was based on field-measured biomass data and satellite remote sensing data from the Moderate resolution imaging spectroradiometer (MODIS). A generalized linear model (GLM) was used to analyze the aboveground biomass (AGB), dynamic changes, and relevance of climatic factors of the typical/desert steppe in Inner Mongolia during the growing seasons from May 2009 to October 2015. The results showed that: (1) The logarithmic function model with the ratio vegetation index (RVI) as the independent variable worked best for the typical steppe area in Inner Mongolia, while the power function model with the normalized differential vegetation index (NDVI) as the independent variable worked best for the desert steppe area. The R2 values at a spatial resolution of 250 m were higher than those at a spatial resolution 500 m. (2) From 2009 to 2015, the highest values of AGB in the typical steppe and desert steppe of Inner Mongolia both appeared in 2012, and were 41.9 Tg and 7.0 Tg, respectively. The lowest values were 30.7 Tg and 5.8 Tg, respectively, in 2009. (3) The overall spatial distribution of AGB decreased from northeast to southwest. It also changed considerably over time. From May to August, AGB at the same longitude increased from south to north with seasonal variations; from August to October, it increased from north to south. (4) A variation partitioning analysis showed that in both the typical steppe and desert steppe, the combined effect of precipitation and temperature contributed the most to the aboveground biomass. The individual effect of temperature contributed more than precipitation in the typical steppe, while the individual effect of precipitation contributed more in the desert steppe. Thus, the hydrothermal dynamic hypothesis was used to explain this pattern. This study provides support for grassland husbandry management and carbon storage assessment in Inner Mongolia.
Socially Responsible Practice and CSR Orientation of Chinese Managers: The Role of Confucian Ethics and Confucian Dynamism
Authors: Li Fuan , Wang Xingyuan , Kashyap Rajiv
Published: November 2019

A concern for socially responsible practice, especially for pro-environmental behavior in emerging economies, has drawn much attention in recent years. The present study contributes to understanding socially responsible decisions of Chinese managers by explicitly modeling the interplay of their social responsibility orientation and endorsement of Confucian principles with regard to investment in environment friendly technology. The results show that Confucian ethics and Confucian dynamism exert significant influence on a socially responsible decision, either directly or through their effect on social responsibility orientation. Nonetheless, they have opposing impacts on managers’ decision-making, which may help explain some anomalous managerial behavior. Implications for research and practice are provided.
Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice
Authors: Sant’Anna Morena Brazil , Lopes Flavia Souza Ribeiro , Kimura Louise Faggionato , Giardini Aline Carolina , Sant’Anna Osvaldo Augusto , Picolo Gisele
Published: November 2019

Neuropathic pain is a disease caused by structural and functional plasticity in central and peripheral sensory pathways that produce alterations in nociceptive processing. Currently, pharmacological treatment for this condition remains a challenge. Crotoxin (CTX), the main neurotoxin of Crotalus durissus terrificus rattlesnake venom, has well described prolonged anti-inflammatory and antinociceptive activities. In spite of its potential benefits, the toxicity of CTX remains a limiting factor for its use. SBA-15 is an inert nanostructured mesoporous silica that, when used as a vehicle, may reduce toxicity and potentiate the activity of different compounds. Based on this, we propose to conjugate crotoxin with SBA-15 (CTX:SBA-15) in order to investigate if when adsorbed to silica, CTX would have its toxicity reduced and its analgesic effect enhanced in neuropathic pain induced by the partial sciatic nerve ligation (PSNL) model. SBA-15 enabled an increase of 35% of CTX dosage. Treatment with CTX:SBA-15 induced a long-lasting reduction of mechanical hypernociception, without modifying the previously known pathways involved in antinociception. Moreover, CTX:SBA-15 reduced IL-6 and increased IL-10 levels in the spinal cord. Surprisingly, the antinociceptive effect of CTX:SBA-15 was also observed after oral administration. These data indicate the potential use of the CTX:SBA-15 complex for neuropathic pain control and corroborates the protective potential of SBA-15.
Newly Discovered Action of HpTx3 from Venom of Heteropoda venatoria on Nav1.7 and Its Pharmacological Implications in Analgesia
Authors: Wu Xinzhou , Wang Zhouquan , Chen Yu , Xu Dehong , Zhang Peng , Wang Xianchun
Published: November 2019

It has been reported that Heteropodatoxin3 (HpTx3), a peptidic neurotoxin purified from the venom of the spider species Heteropoda venatoria, could inhibit Kv4.2 channels. Our present study newly found that HpTx3 also has potent and selective inhibitory action on Nav1.7, with an IC50 of 135.61 ± 12.98 nM. Without effect on the current–voltage (I-V) relationship of Nav1.7, HpTx3 made minor alternation in the voltage-dependence of activation and steady-state inactivation of Nav1.7 (4.15 mV and 7.29 mV, respectively) by interacting with the extracellular S3–S4 loop (S3b–S4 sequence) in domain II and the domain IV of the Nav channel subtype, showing the characteristics of both pore blocker and gate modifier toxin. During the interaction of HpTx3 with the S3b–S4 sequence of Nav1.7, the amino acid residue D in the sequence played a key role. When administered intraperitoneally or intramuscularly, HpTx3 displayed potent analgesic activity in a dose-dependent manner in different mouse pain models induced by formalin, acetic acid, complete Freund’s adjuvant, hot plate, or spared nerve injury, demonstrating that acute, inflammatory, and neuropathic pains were all effectively inhibited by the toxin. In most cases HpTx3 at doses of ≥ 1mg/kg could produce the analgesic effect comparable to that of 1 mg/kg morphine. These results suggest that HpTx3 not only can be used as a molecular probe to investigate ion channel function and pain mechanism, but also has potential in the development of the drugs that treat the Nav1.7 channel-related pain.
Influence of Colostrum and Vitamins A, D3, and E on Early Intestinal Colonization of Neonatal Holstein Calves Infected with Mycobacterium avium subsp. paratuberculosis
Authors: Stabel Judith , Krueger Lucas , Jenvey Caitlin , Wherry Taylor , Hostetter Jesse , Beitz Donald
Published: November 2019

Exposure of neonates to Mycobacterium avium subsp. paratuberculosis (MAP) via infected dams is the primary mode of transmission of Johne’s disease. Little is known about the impacts of feeding colostrum and supplemental vitamins on the gut microbiome in calves exposed to MAP. In the present study, calves were assigned at birth to one of six treatment groups: (1) Colostrum deprived (CD), no vitamins; (2) colostrum replacer (CR), no vitamins; (3) CR, vitamin A; (4) CR, vitamin D3; (5) CR, vitamin E; (6) CR, vitamins A, D3, E, with five calves per treatment in a 14-day study. All calves were orally inoculated with MAP on days 1 and 3 of the study. Differences due to vitamin supplementation were not significant but treatment groups CR-A, CR-E, and CR-ADE had higher numbers of MAP-positive tissues overall. Shannon diversity indices demonstrated regional differences in microbial communities, primarily Proteobacteria, Bacteroidetes, and Firmicutes, between the ileum, cecum, and spiral colon of all calves. CD calves exhibited increased richness compared with CR calves in the cecum and spiral colon and harbored increased Proteobacteria and decreased Bacteroidetes in the mucosa compared with the lumen for all three tissues. Overall, supplementation with vitamins did not appear to influence gut microbiome or impact MAP infection. Feeding of colostrum influenced gut microbiome and resulted in fewer incidences of dysbiosis.