bluuebunny/crossref_metadata_2025 huggingface dataset:
Lynch Syndrome-associated Genomic Variants
Authors: Botea Robert , Piron-Dumitrascu Madalina , Georgescu Tiberiu Augustin , Bohiltea Camil Laurentiu , Voinea Silviu Cristian , Varlas Valentin Nicolae , Iacoban Simona Raluca , Suciu Nicolae
Published: September 2024

Background and Aims: Lynch Syndrome, a hereditary disorder characterized by germline mutations in mismatch repair (MMR) genes, is a major contributor to colorectal cancers. It has also been identified in endometrial cancer. Despite the established role of MMR deficiency in tumorigenesis, the specific genomic alterations driving Lynch syndrome-associated endometrial cancer, and their overlap with colorectal cancer, remain incompletely understood. This study aims to fill this gap by performing a detailed comparative analysis of germline and somatic mutations in endometrial cancer within the context of Lynch syndrome.
Methods: We conducted whole exome sequencing on matched germline and somatic DNA from 13 patients diagnosed with Lynch syndrome-associated endometrial cancer. High-depth sequencing was performed, followed by rigorous bioinformatics analysis to identify and annotate variants, focusing on their potential pathogenicity and relevance to both endometrial and colorectal cancer.
Results: Our analysis revealed 1,118 germline and 14,051 somatic variants, with 493 variants common to both. Recurrent pathogenic mutations in MLH1, MSH2, and MSH6 were confirmed, highlighting their critical role in Lynch syndrome. Notably, frequent somatic mutations in the PIK3CA and PTEN genes were identified, implicating the PI3K/AKT/mTOR pathway as a key oncogenic driver in these cancers. Additionally, novel somatic mutations in genes related to the extracellular matrix such as FBN1 and SPARC were uncovered, suggesting a possible unique role in endometrial tumor progression.
Conclusions: This study provides new insights into the molecular basis of Lynch syndrome-associated endometrial cancer, emphasizing the overlap in oncogenic pathways with colorectal cancer. The discovery of shared and unique genetic mutations highlights the importance of developing combined treatment strategies and suggests that targeting these specific mutations could improve therapy for patients with Lynch syndrome-associated cancers.
Dissolution Enhancement of Ketoconazole by Melt Granulation Co-Processing
Authors:   Laboratory of Pharmacy, Faculty of Chemistry, Autonomous University of Mexico State, Toluca, State of Mexico, Mexico, 50120, Garcia-Radilla Abigail , Ortiz-Reynoso Mariana ,   Laboratory of Pharmacy, Faculty of Chemistry, Autonomous University of Mexico State, Toluca, State of Mexico, Mexico, 50120, Cuevas Gabriel ,   Laboratory of Natural Products Chemistry, Institute of Chemistry, National Autonomous University of Mexico, Mexico City, Mexico, 04510, Alcantara-Fierro Edna T. ,   Laboratory of Pharmacy, Faculty of Chemistry, Autonomous University of Mexico State, Toluca, State of Mexico, Mexico, 50120, Santillán-Benitez Jonnathan G. ,   Laboratory of Molecular Biology, Faculty of Chemistry, Autonomous University of Mexico State, Toluca, State of Mexico, Mexico, 50120
Published: September 2024

Background: Melt granulation (MG) is a simple operation involving a uniform mixture of active ingredients with a melted polymeric carrier. However, this process can also enhance a drug's biopharmaceutical properties by augmenting its dissolution rate and, thus, its absorption. Purpose: By applying MG technology, current research focuses on developing co-processed ketoconazole with a higher aqueous dissolution rate than its pure form. Methods: A measure of how the type and proportion of polymeric carriers affect the crystallinity and dissolution rate of co-processed ketoconazole materials was performed. MG prepared materials in a high-shear mixer using co-povidone (Kollidon®) VA 64, HPMCAS HF as polymeric carriers, PEG 1450 (Kollisolv®) and triethyl citrate as plasticizers. Results: The co-processed ketoconazole materials exhibited miscibility in the polymeric systems, as indicated by the reduction in the enthalpy of fusion. Drug crystallinity was significantly reduced in the HPMCAS HF polymeric system, confirmed by XRPD and ATR-FTIR studies. The dissolution rate was enhanced by using a higher drug concentration in a co-povidone VA 64 environment; contrarily, for HPMCAS HF, a higher drug dilution was observed to favor the dissolution rate. Conclusions: MG is a handy, low-cost technology that develops dissolution-enhanced co-processed active pharmaceutical ingredients, spotting specific carrier-drug interactions. MG yields scalable, proven processes, raising interest in its applications in optimizing drug therapeutic efficacy. Ultimately, this technology for dissolution enhancement could bring lower-cost, high-efficiency drugs to improve patients' quality of life.
Improving Antibiotic Use in Pediatric Preseptal Cellulitis Using a Clinical Practice Guideline
Authors: Cooper Brennen J. , Mitchell Michelle L. , Melamed Svetlana , Liegl Melodee , Pan Amy Y. , Burek Alina G.
Published: September 2024

OBJECTIVES

The purpose of this study was to evaluate the impact of a clinical practice guideline (CPG) on antibiotic use and resource utilization for pediatric preseptal cellulitis.

METHODS

This retrospective quasiexperimental study included patients between the age of 2 months and 17 years admitted for preseptal cellulitis between January 2013 and December 2023. The preseptal cellulitis CPG was implemented in December 2020 using a multifaceted strategy that included buy-in from key stakeholders, education of frontline providers, the official CPG launch, and stakeholder check-ins. The primary outcome was the use of broad-spectrum antibiotics, including dual/triple therapy and methicillin-resistant Staphylococcus aureus (MRSA) active antibiotics. The secondary outcome was resource utilization including blood testing and imaging. Outcomes were compared pre- and post-CPG implementation using the Fisher exact test and logistic regressions.

RESULTS

Of 236 patients meeting inclusion criteria, 175 and 61 patients composed the pre- and post-CPG cohorts, respectively. Median age (interquartile range) was 4.0 (1.8–8.3) years and 46% of the population were female. Post-CPG implementation changes in empirical antibiotic use included decreases in broad-spectrum use from 100% to 66% (P < .001), dual/triple therapy from 47% to 16% (P < .001), and MRSA active agents from 86% to 26% (P < .001). There was a decrease in complete blood count and blood culture orders from 75% to 57% (P = .014) and 32% to 18% (P = .047), respectively.

CONCLUSIONS

Use of broad-spectrum antibiotics, including dual/triple therapy and MRSA active antibiotics for the treatment of pediatric preseptal cellulitis, decreased after CPG implementation.
Determination and safety evaluation of metal element contents of Oviductus Ranae produced from Rana dybowskii by pond culture–forest grazing relay model in Heilongjiang Province, China
Authors: Tang Shizhan , Luan Peixian , Chen Feng , Wang Peng , Qin Dongli , Chen Zhongxiang , Hu Guo
Published: September 2024

The aquatic products of grazing ecological culture exhibit a strong reliance on the production environment system, which may result in heavy metal contamination. In this study, 24 elements (Ag, Al, As, Ba, Cd, Co, Cr, Cs, Cu, Fe, Ga, K, Mg, Mn, Na, Ni, Pb, Rb, Se, Sr, Tl, U, V, Zn) were determined for Oviductus Ranae (OR) from more than 1,000 individuals of Rana dybowskii produced by pond culture–forest grazing relay mode from six major production areas in Heilongjiang Province, China. Furthermore, we assessed the associated health risks. Our findings indicate that most of these 24 metal elements were detected in OR at a detection rate of 100%, with the exceptions being As (98.0%), Ga (98.0%), Co (98.0%), V (94.0%), Cd (89.0%), Pb (76.0%), Cs (74.0%), Tl (35.0%), and U (not detectable). Variations in element concentrations were significant across the six sampling sites, with characteristic elements identified to account for spatial differences. The total target hazard quotient was determined to be 0.152 in Heilongjiang Province, thereby suggesting a relatively low health risk associated with consuming OR from this region’s production systems according to existing standards and guidelines. Nevertheless, special attention is needed for monitoring the habitat environments of R. dybowskii from two sampling locations showing heightened pollution levels.
Composite catalysts based on the CaO‒Fe2O3 system for the oxidative conversion of methane
Authors: Kirik Nadezhda , Rabchevskii Evgenii , Shishkina Nina , Solovyov Leonid , Anshits Alexander
Published: September 2024

The catalysts of the CaO‒Fe2O3 system with Fe2O3 content in the range of 0‒100 wt.% were synthesized by the solid state method at 900 and 1000 °C. The catalysts were characterized by XRD and SEM‒EDX methods, and their activity in the oxidative conversion of methane at 750 °C was studied. The phase composition of the catalysts corresponds to the CaO‒Ca2Fe2O5, Ca2Fe2O5‒CaFe2O4 and CaFe2O4‒a-Fe2O3 regions of the phase diagram. The specific catalytic activity dependence on the Fe2O3 content has an extremum. The CaO‒Ca2Fe2O5 catalysts have the highest reactivity and the active centers in them are localized at the phase interface. The activity of Ca2Fe2O5–CaFe2O4 samples decreases with an increase in the CaFe2O4 content. The CaFe2O4‒a-Fe2O3 catalysts have a core-shell structure and exhibit the least activity, which is determined by the CaFe2O4 shell.
Reflective practice of nurse residents in the teaching-learning process in teaching hospitals
Authors: Paiva Ana Carolina de Oliveira , Silva Kênia Lara
Published: September 2024

ABSTRACT Objective: To analyze reflective practice in the teaching-learning process of nurses in residency programs in teaching hospitals in Minas Gerais, Brazil. Methods: Case study, based on the reflective practice framework, conducted in two teaching hospitals. Observation and interviews were conducted with first and second-year residents, and five participants were included for in-depth analysis, with their data subjected to frequency distribution analysis and Critical Discourse Analysis. Results: In 519 observed activities, elements of reflection were identified in 22.2%, especially active listening and expression of doubts. Discourses indicated practice as the best moment for teaching-learning due to its potential to generate reflections. Learning by doing and case discussion were considered potential strategies for reflective learning. Conclusion: Know-in-action reflection was evidenced as the predominant formative aspect for residents, with few opportunities for reflection on reflection-in-action.
A prática reflexiva de enfermeiros residentes no processo ensino-aprendizagem em hospitais de ensino
Authors: Paiva Ana Carolina de Oliveira , Silva Kênia Lara
Published: September 2024

RESUMO Objetivo: Analisar a prática reflexiva no processo ensino-aprendizagem de enfermeiros em programas de residência em hospitais de ensino de Minas Gerais, Brasil. Métodos: Estudo de caso, baseado no referencial da prática reflexiva, desenvolvido em dois hospitais de ensino. Realizaram-se observação e entrevista de residentes do primeiro e segundo ano, e incluídos, para análise em profundidade, cinco participantes, cujos dados foram submetidos à análise de distribuição de frequência e à Análise do Discurso Crítica. Resultados: Em 519 atividades observadas, houve identificação de elementos de reflexão em 22,2%, especialmente escuta com atenção operativa e expressão de dúvidas. Os discursos indicaram a prática como o melhor momento para o ensino-aprendizagem pelo potencial de produzir reflexões. Aprender fazendo e discussão de casos foram consideradas estratégias potenciais para a aprendizagem reflexiva. Considerações Finais: Evidenciou-se a reflexão conhecer-na-ação como a predominante na formação dos residentes, com poucas oportunidades para reflexão sobre a reflexão-na-ação.
“A ciência como valor cultural” e “A ciência em uma sociedade livre”
Authors: Niiniluoto Ilkka , Silva Vinícius Carvalho da
Published: September 2024

Resumo: Nascido em Helsinque, em 1946, Ilkka Niiniluoto fez mestrado em matemática, em 1968, e doutorado em filosofia teórica, em 1974, na Universidade de Helsinque. Foi Professor Associado de Fundamentos de Matemática, entre 1973 e 1977, e Professor de Filosofia Teórica, de 1977 a 2014. Sua prolífica carreira acadêmica inclui posições como presidente de importantes sociedades filosóficas e reitor da Universidade de Helsinque. Tem, como obras principais: Is Science Progressive? (1984), Truthlikeness (1987), Critical Scientific Realism (2002), Truth-Seeking by Abduction (2018) e Beauty, Truth, and Justice (2022). Sua pesquisa explora as interfaces entre Filosofia da Ciência, Epistemologia, Lógica, Teoria da Verdade e Axiologia da pesquisa científica. Em Critical Scientific Realism, Niiniluoto aborda o problema do valor da ciência, refutando uma concepção instrumentalista utilitária e defendendo um cognitivismo socialmente responsável, em que a ciência é concebida como uma atividade culturalmente valiosa por si mesma, sem a necessidade de satisfazer critérios impostos por necessidades práticas de ordem política e econômica.
Vinte anos da publicação da regulamentação de preços de medicamentos no Brasil: momento de atualizar?
Authors: Melo Valdete Aparecida de , Santana Rafael Santos , Galato Dayani
Published: September 2024

Resumo: Os critérios para definir os preços de medicamentos no Brasil estão previstos na Resolução CMED nº 2/2004 da Câmara de Regulação do Mercado de Medicamentos. Os preços estipulados influenciam o mercado privado e público, o que torna desafiador a revisão de políticas de preços devido a necessidade de harmonizar interesses sociais e econômicos. Uma proposta de revisão dessa Resolução foi disponibilizada por meio da Consulta Pública SEAE nº 2/2021 da Secretaria de Advocacia da Concorrência e Competitividade/Ministério da Economia, porém, até o momento sem publicação dos resultados consolidados até o momento. Recomendações recentes da Organização Mundial da Saúde em relação à adoção de diferentes limiares para definição de preços de medicamentos são adotadas nessa Resolução, embora essa tenha sido publicada há 20 anos. Com o objetivo de interpretar e descrever o alinhamento e os possíveis avanços e retrocessos nos textos legais relacionados à regulação de preços de medicamentos, foi utilizado o método da pesquisa documental analítica-descritiva, de cunho exploratório. Como resultado, foram mantidas a lista de países referência para conferência de preço internacional e os limiares de referenciamento interno e externo de preços. As omissões normativas da Resolução permanecem na Consulta Pública, como a ausência de critérios para precificar radiofármacos, terapias avançadas e medicamentos sem preço internacional, e sem comparadores no mercado brasileiro para revisar preços e transpor preço provisório para definitivo. Um ponto crítico foi a criação de bônus de 35% acima do preço estipulado para medicamentos que apresentem benefício clínico adicional sem, contudo, definir contornos claros quanto às evidências científicas aceitáveis para a comprovação desse benefício. Em suma, poucos avanços foram percebidos na Consulta Pública.
ENSINO HÍBRIDO CRÍTICO-COLABORATIVO: UMA DISCUSSÃO À LUZ DA TEORIA SÓCIO-HISTÓRICO-CULTURAL
Authors: Guimarães Ninin Maria Otilia , Camargo Magalhães Maria Cecília
Published: September 2024

A pandemia Covid-19 deflagrou, na área educacional, um problema relacionado às tecnologias digitais e às suas diferentes abordagens para o ensino. Na ânsia de se encontrar metodologias adequadas ao sistema remoto, optou-se pelo ensino denominado híbrido, mas cujas características indicavam propostas transmissivas, muito mais do que aquelas consideradas antes da pandemia, quando se recorria às tecnologias digitais. Por híbrido, passou-se a entender toda e qualquer proposta de ensino-aprendizagem que recorresse a um mix de instrumentos, com grande ênfase nos tecnológico-digitais. Concepções diversas sobre ensino híbrido, educação híbrida, aprendizagem híbrida, dentre outras denominações, todas elas carregando o estigma do hibridismo, adentraram no sistema educacional e isso vem se propagando desde o período pandêmico até o momento, sem uma efetiva discussão sobre quais bases teóricas orientam essa aprendizagem de caráter híbrido. Essa amálgama de abordagens para “ensino híbrido” orientou uma disciplina da pós-graduação em LAEL, na PUC-SP, no ano de 2021, cujo objetivo foi caracterizar o ensino-aprendizagem híbrido à luz da teoria sócio-histórico-cultural, orientado por metodologias crítico-criativas. Nessa direção, este artigo, seguindo a orientação de desenvolvimento da disciplina, abordará conceitos relacionados a ensino híbrido e suas reverberações, questionando essa visão dicotômica e cognitivista que sustenta muitos modelos assim denominados. Teoricamente, busca apoio no conceito de colaboração crítica e em outros conceitos de natureza sócio-histórico-cultural, confrontando-os aos que sustentam a abordagem hoje considerada de ensino híbrido. Discute uma situação de aprendizagem, ressaltando as características que permitem categorizá-la como atividade de ensino-aprendizagem híbrido na perspectiva sócio-histórico-cultural.
Ecosistema de enseñanza-aprendizaje: programas que acompañan al estudiante
Authors:   Universidad Cooperativa de Colombia, Muñoz Restrepo Alba Luz , Arroyave Villa Norberto Alonso , Jaramillo Jaramillo Wilmar , Betancourt Toro Luz Marina
Published: September 2024

La Universidad Cooperativa de Colombia, en concordancia con su proyecto institucional, se ha consolidado como una institución comprometida con la transformación social y el desarrollo sostenible, en un amplio derrotero de regionalización de la educación, marcado por su sistema multicampus. Su misión se encuentra centrada en la formación integral de profesionales capaces de generar cambios positivos en su entorno; además, se refleja en acciones y actividades concretas orientadas a promover el acceso a la educación superior y fortalecer la inclusión y la equidad. En este contexto, la Universidad dispone de un conjunto de programas que acompañan y blindan al estudiante en su proceso de formación. El eje central de estos programas es brindar apoyo académico, emocional y profesional a los estudiantes durante su trayectoria universitaria, a fin de garantizar su éxito y de contribuir a su desarrollo integral.
Bridging Humanities and Science Education : The SCISSORS Project
Authors: Tuba Orsolya , Fenyvesi Kristóf , Sinnemäki Jukka , Mäki-Kuutti Matias , Yada Takumi , Hofman Agata , Melańczuk Karolina , Csizmazia Katalin , Valovics Ágnes , Suhajda Virág , Suhajda Etelka
Published: September 2024

As a reader, interested in education, you know that science education is more than just teaching scientific concepts and theories. It is about nurturing the students’ curiosity, motivation, and critical thinking skills. However, have you ever considered the connection between science and social competencies? This is where our innovative approach comes in. The purpose of this ebook is to lay the pedagogical foundation for an educational framework combining the sciences and the humanities, and achieve impact through collaborative research and educational activities. Designed for educators, principals of educational institutions and decision-makers seeking to implement a novel pedagogical program, this resource presents valuable materials. Through exploring research-based insights and good practices from Hungary, and Finland, the primary goal is to influence the perspective of teachers regarding the instruction of sciences combined with humanities. This ebook advocates for a paradigm shift where soft skills and critical, analytical thinking are not seen in contrast but as interdependent, fostering a symbiotic relationship for a more impactful and holistic education. Our educational framework offers a pathway for integrating the development of social competencies into the existing structures of diverse school systems, eliminating the necessity for additional staff. Implementing our approach is a preventative measure against burnout for science teachers and other educators and fosters creativity and self-reflection throughout the teaching and learning journey. This method empowers teachers to link natural scientific discoveries with social occurrences, rendering them tangible and comprehensible for students.
A Study of Multiple Comparison Tests with Imprecise and Uncertain Information
Authors:   Research Scholar, Department of Statistics, Dibrugarh University, Dibrugarh, 786004, Assam, India, Kakati Nabanita , Gogoi Bipin
Published: September 2024

Objectives: This study aims to demonstrate the application of multiple comparison tests in situations involving imprecise, incomplete, and uncertain observations. Such data arises in many practical situations. Methods: Five post hoc multiple comparison tests viz. Fisher's LSD test, Tukey's HSD, Bonferroni ( ), Scheffe, and Hochberg ( ) method is utilized within a one-way design framework, with a significance level of 5%. Simulation studies are applied to the empirical level and power calculation. Findings: The study shows that Tukey's HSD ( ) shows the highest power in the determinant part, not the indeterminant part, compared to other tests. For, e.g., For (5, 5, 5, 5) with location parameter (0, .5, 1, 0), the power interval shows [.3953, .3584] where [ ]. Overall, and shows a prominent result and are preferable compared to other tests. From application, NANOVA provided the P-value is [<.001, <.001], i.e., tests are statistically significant. The P-value of the tests for pairs [1, 1] and [1, 1] accepted (greater than .05) means the average daily ICU occupancy of corona patients of more than 55 years and between 35 and 55 age groups are not equal. Similarly, other tests also show the same. Novelty: Neutrosophic Multiple comparisons are still developing, and computer programs are still unavailable to support them. We have applied a simulation study to check the performance of the tests. Keywords: Multiple comparisons, NANOVA, Neutrosophic Statistics, Indeterminacy, Covid-19
ChAT and human alpha-synuclein immunofluorescence staining v1
Authors: La Vitola Pietro
Published: September 2024

This protocol is designed for detecting choline acetyltransferase (ChAT) using the Millipore AB144P (RRID:AB_2079751) and human alpha-synuclein (Abcam, RRID:AB_2537217, MJFR1). Tissues stained with this protocol include 35 μm free-floating mouse brain sections. All tissues were from mice perfused with 4% PFA.
Single-cell RNA sequencing from human dorsal root ganglion v2
Authors: Sankaranarayanan Ishwarya , M Mwirigi Juliet , B Lesnak Joesph , Saad Yousuf Muhammad , Price Theodore
Published: September 2024

This protocol describes how to extract single cells from dorsal root ganglia sourced from human organ donors and perform single-cell RNA sequencing using the Single Cell Gene Expression FLEX kit from 10X Genomics.
SOD2 and human alpha-synuclein immunofluorescence staining v1
Authors: La Vitola Pietro
Published: September 2024

This protocol is designed for SOD2 and human alpha-synuclein staining using the anti-SOD2 (RRID:AB_2636921) and MJFR1-Alexa 488 (RRID:AB_2537217) antibodies. Tissue stained with this protocol include 35 μm free-floating mouse brain sections. All tissue was from mice perfused with 4% PFA.
A Protocol for Assessing Open Data Practices: Honours Students Can Lead the Way. v1
Authors: Deeb Haya , not provided tomasz.zielinski , not provided Andrew.Millar
Published: September 2024

Introduction The culture of scientific research is increasingly recognising the importance of Open Data. Open Data practices involve making research data freely available for others to use, which promotes research integrity, collaboration, and resource efficiency. This protocol aims to assess the openness and FAIRness (Findable, Accessible, Interoperable, and Reusable) of data shared in bioscience research publications. By following this protocol, researchers can systematically evaluate the data-sharing practices in their institutions, thus contributing to a broader culture of open data. This protocol documents the methodology used in the bioscience research field at the University of Edinburgh. The main purpose is to provide a comprehensive and replicable framework that can be adopted by other departments or research domains to evaluate and enhance their data-sharing practices. By sharing this methodology, we invite other institutions and departments to use this protocol to advance the culture of open data in their respective fields. Objective and GoalsObjectiveThe primary objective of this protocol is to evaluate the data-sharing practices in research publications. This involves assessing the completeness, reusability, accessibility, and licensing of data associated with published papers; recording research-related variables such as data types; and publication-related variables such as data availability statements. Goals To provide a structured and consistent methodology for assessing open data practices in bioscience research. To identify trends and challenges in data sharing across different research fields and over time. To promote the adoption of open data practices by highlighting successful examples and areas needing improvement. To encourage Honours students and interns to apply this protocol in their research projects, thus fostering a culture of open data from an early stage in their careers. To encourage other institutions and departments to evaluate their data-sharing practices using this documented methodology, thus fostering a culture of open data across the biosciences.
Deep-learning tool for early identification of non-traumatic intracranial hemorrhage etiology based on CT scan v1
Authors: Zhao Meng
Published: September 2024

Objective To develop anartificial intelligence system that can accurately identify acute non-traumaticintracranial hemorrhage (ICH) etiology based on non-contrast CT (NCCT) scansand investigate whether clinicians can benefit from it in a diagnostic setting. Methods The deep learning modelwas developed with 1868 eligible NCCT scans with non-traumatic ICH collectedbetween January 2011 and April 2018. We tested the model on two independentdatasets (TT200 and SD 98) collected after April 2018. The model’s diagnosticperformance was compared with clinicians’ performance. We further designed asimulated study to compare the clinicians’ performance with and without thedeep learning system augmentation. Results The proposed deeplearning system achieved area under the receiver operating curve of0.986 (95% CI 0.967–1.000) on aneurysms, 0.952 (0.917–0.987) on hypertensivehemorrhage, 0.950 (0.860–1.000) on arteriovenous malformation (AVM), 0.749(0.586–0.912) on Moyamoya disease (MMD), 0.837 (0.704–0.969) on cavernousmalformation (CM), and 0.839 (0.722–0.959) on other causes in TT200 dataset.Given a 90% specificity level, the sensitivities of our model were 97.1% and90.9% for aneurysm and AVM diagnosis, respectively. The model also shows animpressive generalizability in an independent dataset SD98. The cliniciansachieve significant improvements in the sensitivity, specificity, and accuracyof diagnoses of certain hemorrhage etiologies with proposed systemaugmentation. Conclusions The proposed deep learning algorithms can bean effective tool for early identification of hemorrhage etiologies based onNCCT scans. It may also provide more information forclinicians for triage and further imaging examination selection.
Influence of hybrid basalt fibre with varied length on the mechanical properties of normal and high strength concrete
Authors:   Dept. of Civil Engineering, Puducherry Technological University, Puducherry, India, Johnson Jisa , S. Eswari ,   Dept. of Civil Engineering, Puducherry Technological University, Puducherry, India, R. Saravanan ,   Dept. of Civil Engineering, Puducherry Technological University, Puducherry, India
Published: September 2024

Hybrid fibre-reinforced concrete combines different types of fibres or fibres of varying lengths to maximize their individual advantages, which can potentially lead to a synergistic enhancement in overall performance. The main aim of this study is to explore the feasibility of integrating a hybrid fibre system to enhance the efficiency and properties of basalt fibre-reinforced concrete. Specifically, the research focuses on evaluating the mechanical characteristics of basalt hybrid fibre-reinforced concrete across two concrete grades: normal strength M30 and high strength M60. Basalt fibres of 12 mm and 30 mm lengths are used to hybridize the concrete, with a total fibre volume fraction of 1.5%. By incorporating both short and long basalt fibres into the concrete matrix, this study aims to assess how these variations impact essential properties such as workability, compressive strength, flexural strength, and Modulus of Elasticity (MOE). The hybrid mix, comprising 25% of 12 mm fibres and 75% of 30 mm fibres at a volume content of 1.5%, demonstrates enhanced mechanical properties across all concrete grades. The addition of basalt fibres, particularly those with higher proportions of longer fibres, results in a decrease in workability. Notably, hybridizing fibres have no discernible effect on compressive strength or MOE in both concrete grades. From the results it was observed that the flexural strength of the optimal hybrid mixes is significantly higher, surpassing conventional concrete by 39% and 54.35% for M30 and M60 grades of concrete, respectively.
Başarı Duyguları Ölçeği Kısa Versiyonlarının Türk Kültürüne Uyarlanması
Authors: Filiz Ozan , Karademir Coşkun Tuğra
Published: September 2024

Güncel çalışmalar, duyguların öğrenme süreçleriyle güçlü bağlantısını ortaya koymaktadır. Buna karşı duyguların kapsamlı şekilde incelenmesine yönelik veri toplama araçlarında bir ihtiyaç bulunmaktadır. Bu doğrultuda çalışmanın amacı, Bieleke vd. (2021) tarafından geliştirilen başarı duyguları ölçeklerinden Öğrenmeye ve Sınıfa Yönelik Duygular Ölçeklerinin kısa versiyonlarına yönelik geçerlik ve güvenirlik analizlerinin yapılması ve Türk kültürüne uyarlanmasıdır. 725 üniversite öğrencisiyle toplanan verilerin geçerlik çalışmaları doğrulayıcı faktör analizi, güvenirlik çalışmaları Cronbach alfa katsayısı ve Kompozit güvenirliği ile gerçekleştirilmiştir. Doğrulayıcı faktör analizi sonucunda Türk kültürüne uyarlanan ölçeklerin sekiz duygu durumunu (keyif, umut, gurur, öfke, kaygı, utanma, umutsuzluk, sıkılma) ve her bir duygu durumu için dörder toplamda 32 madde içeren orijinal yapısının korunduğu ve kabul edilebilir uyum indislerine sahip olduğu belirlenmiştir. Cronbach alfa katsayılarının Öğrenmeye Yönelik Duygular Ölçeği için 0.804, Sınıfa Yönelik Duygular Ölçeği için 0.782 olduğu, faktörlere ilişkin güvenirlik için CR değeri incelendiğinde, Öğrenmeye Yönelik Duygular Ölçeği için 0.712 ile 0.870, Sınıfa Yönelik Duygular Ölçeği için 0.910 ile 0.962 aralığında değiştiği görülmüştür. Gerçekleştirilen analiz sonuçları, her iki ölçeğin Türkçe formunun geçerli ve güvenilir olduğunu göstermektedir.
Control and data acquisition system to study dielectric breakdown in low-pressure DC plasma reactor with parallels electrodes
Authors: Vieira Magaldi Bernardo , Sávio Pessoa Rodrigo , Pereira Cesare Mateus , André Ribeiro Afonso , Aparecida Martins Cristiane , Soares da Silva Sobrinho Argemiro
Published: September 2024

This work aimed to present the theory of dielectric breakdown of a glow discharge through the automation of gas injection (mass flow) systems with pressure control (pressure gauge) and voltage source with voltage control, in the reactor for the acquisition of rupture parameters for low-pressure glow discharges. Through the analysis of Paschen’s curves for the configuration with argon gases and atmospheric air, it was observed that the rupture potential for argon gas is lower than for atmospheric air, although the ionization potential of atmospheric air is lower about argon.
Automata-based Model of Scientific Activity
Authors:   A. P. Ershov Institute of Informatics Systems, Novosibirsk, 630090, Russian Federation, Shelekhov V. I.
Published: September 2024

The automata model of scientific activity is defined as an extension of the automata model of arbitrary activity. The automata model is built hierarchically and consists of a static part in the form of a set of data sections and a dynamic part defining a set of model processes. The structure of arbitrary activity is considered from the perspective of requirements engineering. To describe the structure of objects, a new data type is introduced: tree set. Tree sets of objects and activities are defined in the activity model. Science as a whole has a hierarchical tree structure and is defined as a tree set of scientific disciplines. The objects of the model of scientific activity are a theory and a set of scientific projects for each scientific discipline. The organisation of scientific activity in Russia is still inefficient. As an alternative, an organisation based on a portfolio of scientific projects formed by a team of leaders for each scientific discipline is considered. The team of leaders is created and updated in accordance with the principle of maximum competence. The apparatus of formal methods and requirements engineering is used to build a model of scientific activity. The static part of the model proposed by the author is formalised.
Особенности культурной политики Республики Корея
Authors: Миронова Татьяна Николаевна
Published: September 2024

Статья посвящена изучению культурной политики Республики Корея. Исследование особенностей ее формирования и реализации на различных этапах исторического развития показывает устойчивость цели по сохранению достижений и накопленного опыта поколений, обеспечению преемственности культурного развития, сохранению национальной идентичности и государственного суверенитета. Вместе с тем культурная политика — это динамичный процесс, в ходе которого цели, задачи и механизмы реализации уточняются и изменяются под воздействием как внутренней, так и внешней политики государства.

Эффективность реализации государственной культурной политики зависит от многих факторов: верно расставленных приоритетов; количества выделяемых на культуру ресурсов; систематического мониторинга за культурным развитием общества; своевременной трансформации модели управления; использования современных средств и технологий сохранения, популяризации и использования культурного наследия и т. д.

Республика Корея применяет достаточно эффективные методы реализации культурной политики. «Корейская волна» (Халлю) популяризирует национальную культуру в мире и повышает экономическую прибыльность корейских товаров. Кибердипломатия нацелена на формирование «достоверного» образа Кореи в мире. Изучение и адаптация данного опыта могут быть полезными в целях эффективной реализации культурной политики разных стран, в том числе и России.
Журналистика и процессы трансформации медиасреды в эпоху информационных войн
Authors: Головин Юрий Алексеевич , Коханая Ольга Евгеньевна
Published: September 2024

В статье рассмотрены границы журналистской деятельности в активно трансформирующемся социокультурном   медиапространстве и роль журналистики в общественной жизни. Проанализированы ключевые особенности функционирования современной медиасреды, такие как неограниченный доступ к контенту любой медиааудитории; увеличение скорости подачи и распространения информации в условиях глобальной медиатизации; неподъемный объем информации, обрушившийся на ее потребителя; стремительная роботизация медиасферы; способы переформатирования сознания посредством средств массовой информации, а также выявлена природа фейков, постправды и симулякров. Авторы обращают внимание на то, что журналистика и СМИ формируют межэтническую медиакультуру участников коммуникационного пространства, демонстрируют аудитории модели политического и социального поведения, что крайне важно в эпоху навязываемых англосаксонским миром ценностей либерализма, глобализма и мультикультурализма. Отмечены назревшие на современном этапе проблемы подготовки специалистов в сфере массмедиа. Отмечен низкий уровень медиакультуры и квалификации производителей контента в новых медиа. Авторами дан прогноз развития медиасферы и в целом цивилизации на ближайшие 30–50 лет.
У истоков проблемы равенства. Часть II
Authors: Канарш Григорий Юрьевич
Published: September 2024

Статья представляет собой продолжение работы автора, опубликованной в журнале «Знание. Понимание. Умение» (2024. № 1). В данной части статьи рассматривается эволюция идеи социального и политического равенства в эпоху раннего Нового времени. Исследуются представления о равенстве в эпоху Возрождения, Реформации, а также в период Английской буржуазной революции. Показано, что в это время, характеризующееся в социальном плане утверждением капиталистических отношений, на первый план выходит идея гражданского равенства (идеи индивидуальной свободы и частной собственности). Это был уже принципиально новый вид равенства по сравнению с Античностью, отражавший характер эпохи (капитализм). Однако уже внутри раннекапиталистического общества формируются важные альтернативные проекты общественного развития, предполагающие возможность индивидуальной свободы и самореализации на основе не частной, а общественной собственности. Это прежде всего коммунистические проекты Т. Мора и Т. Кампанеллы, а также Дж. Уинстенли.  Тем не менее завершение эпохи (конец Английской буржуазной революции) ознаменовался торжеством не социального равенства, а утверждением господства крупной буржуазии и обуржуазившегося дворянства, что, однако, можно рассматривать как прогрессивную модель в данном историческом контексте. Новые горизонты свободы и равенства открывает уже иная эпоха в европейской социальной истории — эпоха Просвещения.
Safety and reliability assessment of CO2 refrigeration system for underground applications below -50 °C
Authors: Barroca Pierre , Verlaat Bart , Teixeira Daniella
Published: September 2024

A new CO2 refrigeration concept is evaluated to cool the ATLAS and CMS experiments installed close to 100 m underground, at the Large Hadron Collider (LHC) at CERN. The first prototype unit produced to validate the conceptual design and to assess safety and reliability of the system has been commissioned. This paper presents results obtained, discusses the safety and reliability of the system and discourses on the list of recommendations for the future final units to cover the cooling loads of 380 kW for ATLAS and 750 kW for CMS at -53 °C evaporation temperature.
The Concept of Material Supervision over Animal Welfare
Authors: Rudy Michał
Published: September 2024

In the context of growing global awareness regarding animal protection and requirements for their treatment, administrative oversight of animal welfare is gaining importance as a key element in ensuring the proper functioning of the state and its institutions in enforcing administrative law norms. The article focuses on defining and discussing the objectives of administrative oversight in the context of animal welfare, highlighting its multidimensional nature, which serves not only to protect animal rights but also to maintain overall welfare standards. Through a review of existing positions in doctrine and jurisprudence, the author aims to define administrative oversight of animal welfare in the material aspect, considering preventive and reactive actions and the main goal, which is to improve living conditions for animals. In light of this perspective, he argues that effectively conducted administrative oversight can contribute to faster and more efficient improvement of living conditions for animals than traditional criminal proceedings. The considerations have both dogmatic and practical significance, emphasizing the role that administrative oversight can play in improving animal welfare. Highlighting the effectiveness of administrative tools in protecting animal rights contributes to the discussion on the superiority of these tools over penal legal measures, offering new perspectives on achieving better living standards for animals.
Considerations on the Legal Position (Rights) of a Witness Remaining with a Party in a Partnership
Authors: Zaremba Konstanty
Published: September 2024

The article aims to present the issue of protecting the rights of a witness who is a partner of a party to the proceedings. The presentation of the legal position of these persons in individual proceedings is based on the analysis of the right to refuse to testify and the right to refuse to answer a question. The key issue is to determine the subjective scope of the above-mentioned rights. Analyzing the provisions of criminal, civil and administrative proceedings, it can be concluded that only the Criminal Procedure Code covers persons living together subjectively. This means that this regulation will not only cover spouses but also persons who are cohabitants. A narrower scope for other procedures may entail procedural and evidentiary problems. The problem also concerns ailments and the method of imposing administrative fines. The article’s purpose is not only to present the problem but also to show a possible solution. Therefore, the postulate de lege ferenda was put forward, showing the potential ways of closing the legal loophole which gives a certain advantage to married persons over those who live only together.
ÜNİVERSİTE ÖĞRENCİLERİNİN TÜKENMİŞLİK, SOSYAL DESTEK VE PSİKOLOJİK İYİ OLUŞLARI İLE İSTEMSİZ ERTELEME EĞİLİMLERİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: Tarsuslu Sinan
Published: September 2024

Bu araştırma, üniversite öğrencilerinin tükenmişlik düzeyleri, sosyal destek algıları ve psikolojik iyi oluş durumları ile istemsiz erteleme eğilimleri arasındaki ilişkileri ve ilişki yönünü belirlemek amacıyla gerçekleştirilmiştir. Bu amaç doğrultusunda ilgili literatürde yer alan ölçekler kullanılmıştır. Ayrıca bu çalışmada tanımlayıcı-ilişki arayıcı türde bir araştırma tipi tercih edilmiştir. Çalışma Erzincan Binali Yıldırım Üniversitesi sağlık hizmetleri meslek yüksekokulunda eğitim gören 1376 öğrenciden 328 kişiye ulaşılarak gerçekleştirilmiştir. Araştırmada örnekleme hatalarını azaltmak ve daha yüksek temsil yeteneğine sahip örneklemler oluşturmak için orantılı tabakalı örnekleme yöntemi kullanılmıştır. Araştırma verileri doğrultusunda öğrencilerin, tükenmişlik düzeyleri ile istemsiz erteleme eğilimleri arasında orta düzeyde pozitif bir ilişki, algıladıkları sosyal destek algıları ile istemsiz erteleme eğilimleri arasında negatif yönlü zayıf bir ilişki, psikolojik iyi oluşları ile istemsiz erteleme eğilimleri arasında negatif yönlü orta düzeyde bir ilişki tespit edilmiştir. Değişkenler arası yapılan regresyon analizi sonucuna göre de öğrencilerin tükenmişlik düzeyinin, algılanan sosyal desteğin ve psikolojik iyi oluşunun istemsiz erteleme eğilimi üzerinde anlamlı bir etkisinin olduğu sonucuna da ulaşılmıştır. Sonuç olarak, araştırma eğitim psikolojisi alanında öğrencilerin akademik başarısını etkileyen önemli bir faktör olan istemsiz erteleme davranışının altında yatan nedenleri daha iyi anlamamıza katkı sağlayarak, öğrencilerin motivasyonunu artırmaya yönelik programların geliştirilmesi için önemli bir araç sağlayacağı düşünülmektedir.
TÜRKÇE ÖĞRETMENİ ADAYLARININ TÜRKÇE EĞİTİMİ BÖLÜMÜNE/ÖĞRETMENLİĞİNE GÜDÜLENME DÜZEYLERİ İLE İLGİLİ GÖRÜŞLERİ
Authors: Gömleksiz Mehmet , Doğan Fatma Nur , Sinan Ahmet Turan
Published: September 2024

Bu araştırmada Türkçe öğretmeni adaylarının Türkçe Eğitimi Bölümüne/Öğretmenliğine yönelik güdülenme düzeylerinin cinsiyet, sınıf düzeyi ve üniversite değişkenleri açısından incelenmesi amaçlanmıştır. Tarama modelinin kullanıldığı bu araştırmanın çalışma grubu Erzincan Binali Yıldırım Üniversitesi, Dicle Üniversitesi, Fırat Üniversitesi, İnönü Üniversitesi, Nevşehir Hacı Bektaş Veli Üniversitesi, Erciyes Üniversitesi, Cumhuriyet Üniversitesi, Siirt Üniversitesi ve Adıyaman Üniversitesi Eğitim Fakültelerinin Türkçe Eğitimi Bölümlerinin 1 ve 4. sınıfında öğrenim gören toplamda 809 Türkçe öğretmeni adayından oluşmaktadır. Veri toplama aracı olarak Arslan (2011) tarafından geliştirilen Türkçe Öğretmeni Adaylarının Türkçe Eğitimi Bölümüne ve Öğretmenliğine Yönelik Güdülenme Düzeyleri Ölçeği kullanılmıştır. Araştırma sonucunda öğretmen adaylarının güdülenme düzeylerinin bütün değişkenler bakımından istatistiksel olarak anlamlı bir şekilde farklılaştığı belirlenmiştir. Yapılan karşılaştırmalarda kadın öğretmen adaylarının erkeklerden, 1. sınıfların 4. sınıflardan daha yüksek güdülenme düzeyine sahip oldukları tespit edilmiştir. Üniversite değişkenine yönelik yapılan karşılaştırmada ise Siirt ve Dicle Üniversitelerinin daha düşük güdülenme düzeyinde olduğu belirlenmiştir. Bununla birlikte Türkçe öğretmeni adaylarının yüksek güdülenme düzeyine sahip oldukları sonucuna ulaşılmıştır.
Determinants of Economic Dynamism among the 22 Municipalities in the Philippines
Authors: Capulong Charlyn M. , Abing Martha Joy J. , Teves Maria Rizalia Y. , Babanto Gerrich Aldin C.
Published: September 2024

This study was conducted to identify the determinants of economic dynamism as proxy to investment climate of the 22 Municipalities in the Philippines. The variables namely infrastructure pillar, government efficiency pillar, and resiliency pillar from the Cities and Municipalities Competitiveness (CMCI) Survey are the independent variables considered in the study. Using panel regression in the analysis, the results show that economic dynamism is significantly driven by government efficiency and infrastructure pillars. Furthermore, the study revealed that economic dynamism scores of the Municipalities are increasing overtime as shown by the time effect component in the model. This suggests that the municipalities had improved their business climate over time, even during the pandemic. Based on the results, it is recommended that local government units (LGUs) focus on improving their performance under the indicators of government efficiency and infrastructure pillar to create a more business-friendly environment and attract more investors. Additionally, while the resiliency pillar did not show a statistically significant effect on economic dynamism, further review and enhancement of the indicators measuring resilience were suggested to better capture its impact.
The Influence of Gross Regional Domestic Product Per Capita and Foreign Direct Investment on Income Inequality: An Empirical Study of 34 Provinces in Indonesia
Authors: Maichal Maichal , Hartono Powell Gian , Firman Afrizal , Yudha I Made Endra Kartika
Published: September 2024

The study investigates the correlation between Gross Regional Domestic Product (GRDP) per capita, Foreign Direct Investment (FDI), and the Gini coefficient using panel data from 34 provinces in Indonesia from 2015 to 2023. A panel data regression analysis method was employed for data processing to optimize estimation results. The results obtained from the analysis using the Fixed Effects Model (FEM) consistently show strong positive outcomes. The findings imply a direct connection between higher GRDP per capita, increased FDI, and a higher Gini coefficient, suggesting that more significant foreign investment and higher per capita GDP contribute to increased income inequality across the Indonesian provinces. The study emphasizes the critical role of regional governments in addressing these disparities. It suggests strategies such as implementing regional policies to boost investment, enhancing infrastructure, creating more business opportunities, and promoting tourism. The proposal to establish the National Capital City (IKN) in East Kalimantan is presented as a long-term solution to reduce income inequality among the provinces.