bluuebunny/crossref_metadata_2025 huggingface dataset:
Whole genome sequencing data of Candida krusei, pathogen causing Candidaemia, from Department of Parasitology Culture Collection, Faculty of Medicine Universitas Indonesia
Authors: Fadilah Fadilah , Adawiyah Robiatul , Wahyuningsih Retno , Rozaliyani Anna , Fatril Ayu Eka , Paramita Rafika Indah , Erlina Linda , Istiadi Khaerunissa Anbar
Published: June 2022

Candida krusei is a Candida non-albicans species with a high prevalence, which causes candidaemia. Current treatment guidelines include fluconazole as a primary therapeutic option for the treatment of these infections; however, it is only a fungistatic against Candida spp., and both inherent and acquired resistance to fluconazole have been reported. C. krusei species is also reported as the only Candida sp. which has an intrinsic resistance factor to fluconazole. Therefore, in dealing with antifungal resistance, it is necessary to develop new antifungal agents that are efficient in the treatment of fungal infections, especially those caused by C. krusei. The purpose of this study was to investigate the genome of clinical C. krusei isolates and correlate the resistant phenotypes with mutations in resistance genes. A total of 16 samples of C. krusei from clinical samples from hospitals in Jakarta were used in the experiment. All colonies were extracted using the QIAamp DNA Mini Kit. The library was prepared using the Illumina DNA Prep Kit. The sequencing process was carried out on the Illumina MiSeq Platform using a 2x301 paired-end configuration. FASTQ raw files are available under the BioProject Accession Number PRJNA819536 and Sequence Read Archive Accession Numbers SRR18739949 and SRR18739964.
Case Report: Central retinal artery occlusion following sildenafil intake
Authors: Mahmoud Anis , Abid Fatma , Khairallah Molka , Sakji Fatma , Ibn Hadj Amor Hassen , Attia Hala , Mbarek Sameh , Messaoud Riadh
Published: June 2022

Purpose: To report a case of central retinal artery occlusion associated with sildenafil intake and briefly discuss its causative pathogenesis.

Methods: A 50-year-old man with no premorbidities presented with symptoms of sudden severe visual field constriction in the left eye (LE). Best-corrected visual acuity in the LE was 20/25. Fundus examination and fluorescein angiography of the LE were suggestive of central retinal artery occlusion (CRAO) with cilioretinal artery sparing. Further investigation revealed that 100 mg of sildenafil had been taken for the first time three hours before the onset of symptoms.

Results: The patient was treated promptly with intravenous acetazolamide, sublingual isosorbide dinitrate and ocular massage, but without visual recovery. No other associated systemic or local risk factors were found, and the case was classified as a potential complication of sildenafil.

Conclusion: Although no direct link could be established, the aim of this report is to highlight the incidence and to consider this issue when evaluating any case of central retinal artery occlusion.
Opposition, comparison, and associativity: On Luis J. Prieto as a reader of the Cours de linguistique générale
Authors: Chávez Barreto E. Israel
Published: June 2022

This paper aims to show the role played by the relations of comparison and associativity, as they are introduced in Saussure’s Cours de linguistique générale, in the theories of Luis J. Prieto. This is done, first, on the basis of a historiographical approach, and second, on the basis of an exegetical approach to Prieto’s works. Thus, the paper first presents and analyses three programmes, corresponding to three courses Prieto gave at the Universidad Nacional de Córdoba during the early 1950s. The analysis of these programmes will show the centrality of Saussure’s Cours in Prieto’s linguistic theorizing. After this, an attempt will be made to show the continuity between the theoretical tenets presupposed by the courses’ programmes and the main proposal advanced in Prieto’s article “Classe et concept. Sur la pertinence et sur les rapports saussuriens ‘de comparaison’ et ‘d’échange’”. By constructing this continuity we attempt to show: (1) the constant influence the Cours exerted upon Prieto’s thinking throughout his whole career, and (2) that such influence is manifested in the fact that Prieto did not generalize linguistic principles as such, but rather posited that linguistic principles were instances of more general semiotic ones.
The Trika School - A Religio-Philosophical Emergence
Authors: Sharma Niharika
Published: June 2022

The worship of Śiva as a deity was the dominant form of theistic and religious devotion which flowed through Kashmir to other parts of India from the first century BC. The Trika school is an idealistic, monistic, and theistic school of philosophy in Śaivism, that originated in the ninth century C.E. in Kashmir. The study attempts to elucidate the historical development of Trika school along with the idiosyncratic and unique philosophy of the school. The paper further endeavours to explain the enthralling development of this particular school which can best be understood from a religio-philosophical context. The study employs textual analysis and conceptual enquiry as the research method to analyse and present the development and distinct nature of the Trika school.
Patient experience of informed consent for diagnostic coronary angiogram and follow-on treatments
Authors: Blanchard Howard T , Carroll Diane L , Astin Felicity
Published: June 2022

Background/Aims

Coronary angiography requires a complex informed consent process as a legal and ethical requirement before treatment. This process may allow percutaneous coronary intervention to be completed as a continuation of a coronary angiography. Patients routinely consent to both interventions, but over one-quarter will only receive the diagnostic angiogram. This study explored views and understandings of the informed consent process, and associations with demographic characteristics, among patients who consented to coronary angiography and same-setting percutaneous coronary intervention, but were found to be ineligible for the latter.

Methods

A descriptive cross-sectional survey design was used to explore patients' views. A total of 62 participants (73% male, mean age 68.4 years) completed a 36-item survey the day after undergoing diagnostic coronary angiography.

Results

Female participants reported greater difficulty in recalling treatment information (P<0.03), found discussions about alternative treatments more confusing (P<0.02), and the disclosure of comprehensive risk information more of a deterrent to consent for treatment (P<0.02) compared to men. Higher levels of education were associated with greater preference for information and involvement in treatment decisions (P<0.002).

Conclusions

Patients who give informed consent for diagnostic coronary angiography with or without a same-setting percutaneous coronary intervention need clear comprehensive information regarding alternative options. By recognising the patient's need for information, nurses can provide an individualised explanation and reinforcement of the information provided during informed consent.
Highlighting the latest research: May 2022
Authors: Palmer Sarah Jane
Published: June 2022

Sarah Jane Palmer presents a selection of recently published articles of interest to nurses working in cardiovascular nursing. The aim of this roundup is to provide a brief overview of the research papers selected. A full reference is provided for those who wish to look at the research in further detail.
Accuracy and remunerative implications of clinical coding in elective plastic surgery
Authors: Georgiou A , Ruston J , Haque S , Woollard A
Published: June 2022

Introduction

Accurate coding is essential to ensure correct remuneration for clinical procedures. However, coders are non-clinical, and use operative and discharge notes to infer what they think are appropriate codes. As plastic surgery encompasses a huge variety of procedures, the codes used may not reflect the procedures performed.

Methods

Electronic records from July/August 2019 were consulted to identify commonly performed procedures on elective lists that were then reviewed retrospectively by a coding auditor and a clinician. Procedures were chosen to reflect a range of plastic surgery, including hand surgery, breast surgery and general plastic surgery. The changes to the clinical codes (procedural and diagnostic) and Healthcare Resource Group tariff implications were analysed. The audit loop was completed in July 2020 after the introduction of clinical coding improvement strategies.

Results

A total of 65 relevant cases were included. Changes were made in 31 cases (24 changes to OPCS-4 codes and 7 changes to ICD-10 codes). Significant remunerative implications for the department were noted (£209 per patient on average).

Conclusions

This study has demonstrated a clear need for collaboration between clinicians and coders. Increased surgeon awareness of clinical coding and clear documentation are essential. We have presented strategies to improve coding as part of a continued quality improvement.
Terahertz imaging using optically controlled Fourier-basis structured illumination
Authors: Grossman Erich N. , Feldkhun Daniel , McComb Sean , Wagner Kelvin
Published: June 2022

We demonstrate that a new type of structured-illumination imaging may be migrated from the optical to the terahertz domain. This Fourier-basis technique involves illuminating a target with rapidly moving sinusoidal fringes of controllable spatial frequency and orientation, while measuring the scattered radiation on a single fast detector. This initial proof-of-concept demonstration is purely one-dimensional since the fringe orientation is fixed, but the technique is readily extensible to two dimensions. The fringes are first generated in the near-infrared (808 nm) by passing a high-power laser beam through an acousto-optic Bragg cell driven by a superposition of two RF signals slightly offset in frequency, blocking the undeflected beam, and refocusing the two diffracted beams onto a metal-backed semiconductor wafer. The laser can be amplitude modulated to slow down the moving fringes to accommodate the semiconductor’s temporal response. The semiconductor acts as an optically addressed spatiotemporal modulator for a THz beam illuminating the same area. The periodic optical fringes effectively transform the semiconductor into a reflective THz diffraction grating with a programmable period. The diffracted THz radiation is then imaged onto the remote target plane, where the diffraction orders interfere pairwise to create traveling THz fringes. Scattered radiation from the target is collected by a simple receiver operating in “light bucket” mode, which produces an output signal consisting of a superposition of sinusoidal tones, one for each spatial Fourier component of the target. We present measurements of the THz fringe projector’s performance and compare with a model of the semiconductor modulator’s operation. Finally, we present Fourier-reconstructed images of pairs of point targets as an initial demonstration of THz Fourier-basis agile structured illumination sensing imaging.
Hybrid laser activated phycocyanin/capecitabine treatment of cancerous MCF7 cells
Authors: Jahdi Abdollahi Sahar , Parvin Parviz , Mayahi Sara , Seyedi Solaleh , Mohsenian Parnian , Ramezani Fatemeh
Published: June 2022

Laser-induced fluorescence is recently used as an efficient technique in cancer diagnosis and non-invasive treatment. Here, the synergic therapeutical efficacies of the Capecitabine (CAP) chemodrug, photosensitive Phycocyanin (PC) and graphene oxide (GO) under laser irradiation were investigated. The therapeutical efficacies of diverse concentrations of CAP (0.001-10 mg/ml) and PC (0.5-10 mg/ml) alone and with laser irradiation on human breast adenocarcinoma (MCF-7) cells were examined. The interactional effects of 100 mW SHG Nd:YAG laser at 532nm and GaAs laser at 808 nm ranging power of 150 mW- 2.2W were considered. The contribution of graphene oxide (GO) in biocompatible concentrations of 2.5-20 ng/ml and thermal characteristics of laser exposure at 808 nm on GO + fluorophores have been studied. The effects of the bare and laser-excited CAP + PC on cell mortality have been obtained. Despite the laser irradiation could not hold up the cell proliferation in the absence of drug interaction considerably; however, the viability of the treated cells (by a combination of fluorophores) under laser exposure at 808 nm was significantly reduced. The laser at 532 nm excited the fluorescent PC in (CAP + PC) to trigger the photodynamic processes via oxygen generation. Through the in-vitro experiments of laser-induced fluorescence (LIF) spectroscopy of PC + CAP, the PC/CAP concentrations of the maximum fluorescence signal and spectral shifts have been characterized. The synergic effects of the laser exposures and (CAP + PC) treatment at different concentrations were confirmed. It has been shown here that the laser activation of (CAP + PC) can induce the mortality of the malignant cells by reducing the chemotherapeutic dose of CAP to avoid its non-desirable side effects and by approaching the minimally invasive treatment. Elevation of the laser intensity/exposure time could contribute to the therapeutic efficacy. Survival of the treated cells with a combination of GO and fluorophores could be reduced under laser exposure at 808 nm compared to the same combination therapy in the absence of GO. This survey could benefit the forthcoming clinical protocols based on laser spectroscopy for in-situ imaging/diagnosis/treatment of adenocarcinoma utilizing PC + CAP + GO.
Few-cycle short-wave-infrared light source for strong-field experiments at 200 kHz repetition rate
Authors: Sytcevich Ivan , Viotti Anne-Lise , Guo Chen , Vogelsang Jan , Langer Fabian , L’Huillier Anne , Arnold Cord L.
Published: June 2022

We present a compact, few-cycle, short-wave infrared light source delivering 13 µJ, carrier-envelope phase (CEP) stable pulses around 2 µm, operating at 200 kHz repetition rate. Starting from an ytterbium fiber amplifier, the seed is produced via white-light generation followed by difference frequency generation, and later amplified in two BiBO nonlinear crystals. A pulse duration of 15.8 fs is measured with the dispersion scan technique, while the CEP stability is assessed via a monolithic spectral interferometry scheme. We demonstrate the potential of the system to drive strong-field experiments by performing high-order harmonic generation in argon gas.
Ultra-broadband long-wave-infrared pulse production using a chirped-pulse difference-frequency generation
Authors: Huang H. , Xiao X. , Burger M. , Nees J. , Jovanovic I.
Published: June 2022

We present a broadband light source based on near-infrared chirped-pulse difference-frequency mixing that is suitable for seeding long-wave-infrared (LWIR) optical parametric chirped-pulse amplification (OPCPA). A nitrocellulose pellicle is used in a Ti:sapphire regenerative amplifier to generate dual-frequency output pulses, which are subsequently mixed in a 0.4-mm thick AgGaS2 crystal. LWIR pulses with ∼1 µm full width at half maximum (FWHM) bandwidth centered at 10.5 µm are generated by mixing transform-limited pulses. Assisted by genetic algorithm optimization, the bandwidth is broadened to ∼3 µm FWHM within the 8–12 µm atmospheric transmission window. The seed source paves the path towards tabletop ultrafast terawatt-class passively carrier-envelope-phase stabilized OPCPA in the LWIR region.
Skeletal Muscle Satellite Cells in Sickle Cell Disease Patients and Their Responses to a Moderate-intensity Endurance Exercise Training Program
Authors: Januel Léa , Merlet Angèle N. , He Zhiguo , Hourdé Christophe , Bartolucci Pablo , Gellen Barnabas , Galactéros Frédéric , Messonnier Laurent A. , Féasson Léonard
Published: June 2022

We previously demonstrated that 8 weeks of moderate-intensity endurance training is safe and improves muscle function and characteristics of sickle cell disease (SCD) patients. Here, we investigated skeletal muscle satellite cells (SCs) in SCD patients and their responses to a training program. Fifteen patients followed the training program while 18 control patients maintained a normal lifestyle. Biopsies of the vastus lateralis muscle were performed before and after training. After training, the cross-sectional area and myonuclear content in type I fibers were slightly increased in the training patients compared to non-training patients. The SC pool was unchanged in type I fibers while it was slightly decreased in type II fibers in the training patients compared to non-training patients. No necrotic fibers were detected in patients before or after training. Therefore, the slight myonuclear accretion in type I fibers in trained SCD patients may highlight the contribution of SCs to training-induced slight type I fiber hypertrophy without expansion of the SC pool. The low training intensity and the short duration of training sessions could explain the low SC response to the training program. However, the lack of necrotic fibers suggests that the training program seemed to be safe for patients’ muscle tissue.
Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice
Authors: Oura Seiya , Hino Toshiaki , Satoh Takashi , Noda Taichi , Koyano Takayuki , Isotani Ayako , Matsuyama Makoto , Akira Shizuo , Ishiguro Kei-ichiro , Ikawa Masahito
Published: June 2022

Meiosis is a hallmark event in germ cell development that accompanies sequential events executed by numerous molecules. Therefore, characterization of these factors is one of the best strategies to clarify the mechanism of meiosis. Here, we report tripartite motif-containing 41 (TRIM41), a ubiquitin ligase E3, as an essential factor for proper meiotic progression and fertility in male mice. Trim41 knockout (KO) spermatocytes exhibited synaptonemal complex protein 3 (SYCP3) overloading, especially on the X chromosome. Furthermore, mutant mice lacking the RING domain of TRIM41, required for the ubiquitin ligase E3 activity, phenocopied Trim41 KO mice. We then examined the behavior of mutant TRIM41 (ΔRING-TRIM41) and found that ΔRING-TRIM41 accumulated on the chromosome axes with overloaded SYCP3. This result suggested that TRIM41 exerts its function on the chromosome axes. Our study revealed that Trim41 is essential for preventing SYCP3 overloading, suggesting a TRIM41-mediated mechanism for regulating chromosome axis protein dynamics during male meiotic progression.
Analysis of secondary metabolite gene clusters and chitin biosynthesis pathways of Monascus purpureus with high production of pigment and citrinin based on whole-genome sequencing
Authors: Zhang Song , Zeng Xiaofang , Lin Qinlu , Liu Jun
Published: June 2022

Monascus is a filamentous fungus that is widely used for producing Monascus pigments in the food industry in Southeast Asia. While the development of bioinformatics has helped elucidate the molecular mechanism underlying metabolic engineering of secondary metabolite biosynthesis, the biological information on the metabolic engineering of the morphology of Monascus remains unclear. In this study, the whole genome of M. purpureus CSU-M183 strain was sequenced using combined single-molecule real-time DNA sequencing and next-generation sequencing platforms. The length of the genome assembly was 23.75 Mb in size with a GC content of 49.13%, 69 genomic contigs and encoded 7305 putative predicted genes. In addition, we identified the secondary metabolite biosynthetic gene clusters and the chitin synthesis pathway in the genome of the high pigment-producing M. purpureus CSU-M183 strain. Furthermore, it is shown that the expression levels of most Monascus pigment and citrinin clusters located genes were significantly enhanced via atmospheric room temperature plasma mutagenesis. The results provide a basis for understanding the secondary metabolite biosynthesis, and constructing the metabolic engineering of the morphology of Monascus.
A long-term study indicates that tree clearance negatively affects fledgling recruitment to the Blue-fronted Amazon (Amazona aestiva) population
Authors: Seixas Gláucia Helena Fernandes , Mourão Guilherme
Published: June 2022

The Blue-fronted Amazon (Amazona aestiva) is a Neotropical parrot with a large distribution in South America, including areas in Brazil, Bolivia, Argentina and Paraguay. A substantial part of the population of this parrot is concentrated in the Pantanal, a large wetland located in the center of South America. There, the clearing of forest and savannas has occurred through the years to accommodate beef-cattle pasture, and crops. Our objective was to understand the direct and indirect effects of time, availability of forest and savannas, and rainfall over the number of nestlings and fledged young of Blue-fronted Amazons inhabiting the southern Pantanal. We surveyed their nests from 1997 to 2018 and counted the number of nestlings produced and the number of fledglings capable to leave the nest in each year. Additionally, we used available data on the area covered by arboreal vegetation, and rainfall data collected at a Meteorological Station located in a central area of the study, as predictors of the numbers of nestlings and fledglings produced every year. Then, we applied structural equation modeling to examine both the direct and indirect effects of time, arboreal habitat availability, and annual cumulative rainfall on the number of nestlings and fledgling per nest. Finally, we estimated the long-term trend of the number of fledglings per nest as a surrogate to the populational trend of Blue-fronted Amazon. We found that none of the variables in our model explained the number of nestlings in nests, but the number of nestlings and the arboreal habitat availability directly and positively affected the number of fledglings. Time indirectly and negatively affected the number of fledglings per nest, whereas rainfall affected it indirectly positively. Additionally, we detected a concerning decrease of about 30% of the fledglings during the 22-years study, which could lead to a change in the species conservational status.
Determinants of the COVID-19 vaccine hesitancy spectrum
Authors: Piltch-Loeb Rachael , Silver Diana R. , Kim Yeerae , Norris Hope , McNeill Elizabeth , Abramson David M.
Published: June 2022

Vaccine hesitancy remains an issue in the United States. This study conducted an online survey [N = 3,013] using the Social Science Research Solution [SSRS] Opinion Panel web panelists, representative of U.S. adults age 18 and older who use the internet, with an oversample of rural-dwelling and minority populations between April 8 and April 22, 2021- as vaccine eligibility opened to the country. We examined the relationship between COVID-19 exposure and socio-demographics with vaccine intentions [eager-to-take, wait-and-see, undecided, refuse] among the unvaccinated using multinomial logistic regressions [ref: fully/partially vaccinated]. Results showed vaccine intentions varied by demographic characteristics and COVID-19 experience during the period that eligibility for the vaccine was extended to all adults. At the time of the survey approximately 40% of respondents were unvaccinated; 41% knew someone who had died of COVID-19, and 38% had experienced financial hardship as a result of the pandemic. The vaccinated were more likely to be highly educated, older adults, consistent with the United States initial eligibility criteria. Political affiliation and financial hardship experienced during the pandemic were the two most salient factors associated with being undecided or unwilling to take the vaccine.
Incorporating the effect of heterogeneous surface heating into a semi-empirical model of the surface energy balance closure
Authors: Wanner Luise , Calaf Marc , Mauder Matthias
Published: June 2022

It was discovered several decades ago that eddy covariance measurements systematically underestimate sensible and latent heat fluxes, creating an imbalance in the surface energy budget. Since then, many studies have addressed this problem and proposed a variety of solutions to the problem, including improvements to instruments and correction methods applied during data postprocessing. However, none of these measures have led to the complete closure of the energy balance gap. The leading hypothesis is that not only surface-attached turbulent eddies but also sub-mesoscale atmospheric circulations contribute to the transport of energy in the atmospheric boundary layer, and the contribution from organized motions has been grossly neglected. The problem arises because the transport of energy through these secondary circulations cannot be captured by the standard eddy covariance method given the relatively short averaging periods of time (~30 minutes) used to compute statistics. There are various approaches to adjust the measured heat fluxes by attributing the missing energy to the sensible and latent heat flux in different proportions. However, few correction methods are based on the processes causing the energy balance gap. Several studies have shown that the magnitude of the energy balance gap depends on the atmospheric stability and the heterogeneity scale of the landscape around the measurement site. Based on this, the energy balance gap within the surface layer has already been modelled as a function of a nonlocal atmospheric stability parameter by performing a large-eddy simulation study with idealized homogeneous surfaces. We have further developed this approach by including thermal surface heterogeneity in addition to atmospheric stability in the parameterization. Specifically, we incorporated a thermal heterogeneity parameter that was shown to relate to the magnitude of the energy balance gap. For this purpose, we use a Large-Eddy Simulation dataset of 28 simulations with seven different atmospheric conditions and three heterogeneous surfaces with different heterogeneity scales as well as one homogeneous surface. The newly developed model captures very well the variability in the magnitude of the energy balance gap under different conditions. The model covers a wide range of both atmospheric stabilities and landscape heterogeneity scales and is well suited for application to eddy covariance measurements since all necessary information can be modelled or obtained from a few additional measurements.
Systematic review of the physiological and health-related effects of radiofrequency electromagnetic field exposure from wireless communication devices on children and adolescents in experimental and epidemiological human studies
Authors: Bodewein Lambert , Dechent Dagmar , Graefrath David , Kraus Thomas , Krause Tobias , Driessen Sarah
Published: June 2022

Background

For more than 20 years, the potential health risks of radiofrequency electromagnetic field (RF EMF) exposure from mobile communication devices on children and adolescents have been examined because they are considered sensitive population groups; however, it remains unclear whether such exposure poses any particular risk to them.

Objectives

The aim of this review was to systematically analyze and evaluate the physiological and health-related effects of RF EMF exposures from wireless communication devices (mobile phones, cordless phones, Bluetooth, etc.) on children and adolescents.

Methods

This review was prepared according to thePreferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) guidelines. Methodological limitations in individual studies were assessed using the Office of Health Assessment and Translation (OHAT) Risk-of-Bias Rating Tool for Human and Animal Studies.

Results

A total of 42 epidemiological and 11 experimental studies were eligible for this review. Most of the studies displayed several methodological weaknesses that limited the internal validity of the results. Due to a lack of consistency regarding the outcomes as well as the lack of scientific rigor in most reviewed studies, the body of evidence for the effects of RF EMF of mobile communication devices on subjective symptoms, cognition, and behavior in children and adolescents was low to inadequate. Evidence from the studies investigating early childhood development, brain activity, cancer, and physiological parameters was considered inadequate for drawing conclusions about possible effects.

Discussion

Overall, the body of evidence allows no final conclusion on the question whether exposure to RF EMF from mobile communication devices poses a particular risk to children and adolescents. There has been rapid development in technologies generating RF EMF, which are extensively used by children and adolescents. Therefore, we strongly recommend high-quality systematic research on children and adolescents, since they are generally considered as sensitive age groups.
Association between workplace psychological violence and work engagement among emergency nurses: The mediating effect of organizational climate
Authors: Hu Huiling , Gong Haiyan , Ma Dongmei , Wu Xue
Published: June 2022

Background

Given that increasing attention is being given to the burdens on medical systems, researchers have concentrated their attention on nurses’ work engagement, especially in emergency departments.

Purpose

To investigate the current situation of work engagement of nurses in emergency department, and to find out the impact of psychological violence on work engagement and its impact path.

Basic procedures

The research is a cross-sectional study. Questionnaires were distributed to 243 nurses from the emergency departments of ten tertiary hospitals from September to October 2019. SPSS was used to conducted ANOVA. The AMOS was used to conduct structural equation model to test the mediating effect of organizational climate on the association between psychological violence and dimensions of work engagement.

Main findings

Psychological violence was negatively correlated with organizational climate, vitality, dedication, and focus, and organizational climate was positively correlated with dimensions of work engagement. A negative relationship was found between psychological violence and three dimensions of work engagement, which was mediated by organizational climate.

Conclusion

In order to curb workplace psychological violence and improve the work engagement level of emergency nurses, organizational climate can be used as an intervention measure. The support of leaders, the care of colleagues and the mutual understanding and communication between doctors and patients can alleviate the job burnout of nurses in the face of heavy work, so that nurses can face their daily work with a better mental outlook.
Knowledge of vaccine handlers and status of cold chain and vaccine management in primary health care facilities of Tigray region, Northern Ethiopia: Institutional based cross-sectional study
Authors: Gebretnsae Hailay , Hadgu Tsegay , Ayele Brhane , Gebre-egziabher Equbay , Woldu Mulugeta , Tilahun Mulugeta , Abraha Alemnesh , Wubayehu Tewolde , Medhanyie Araya Abrha
Published: June 2022

Background

Ethiopia federal ministry of health has been working on increasing access to immunization service by deploying solar refrigerators to primary health care facilities. However, there is limited evidence on cold chain and vaccine management status. Therefore, the objective of this study was to assess knowledge of vaccine handlers and status of cold chain and vaccine management and their associated factors in primary health care facilities of Tigray region Northern Ethiopia.

Methods

Institutional based cross-sectional study was conducted in four randomly selected districts of Tigray region, Northern Ethiopia. In each selected district, all primary health care facilities with functional vaccine refrigerators were included in the study. Data were collected using a pre-tested semi-structured questionnaire. The collected data were entered into Epi-data version 3.1 and then exported to Statistical Package for Social Sciences (SPSS) version 21 for analysis. All variables with p-value of < 0.25 in bivariate logistic regression analysis were included in multi-variable model to identify predictors of the dependent variables.

Results

In this study, fifty Primary Health Care Facilities (PHCFs) were included with a response rate of 94.4%. The overall level of good knowledge of vaccine handlers and good status of cold chain and vaccine management were 48% (95% CI; 30.7%-62%) and 46% (95%CI; 26.1%-61.3%) respectively. Receiving training on cold chain and vaccine management (AOR = 5.18; 95%CI: 1.48–18.18) was significantly associated with knowledge of vaccine handlers. Furthermore, receiving supportive supervision (AOR = 4.58; 95%CI: 1.04–20.17) and good knowledge of vaccine handlers (AOR = 10.97; 95%CI: 2.67–45.07) were significant associated with cold chain and vaccine management.

Conclusions

This study showed that knowledge of vaccine handlers on cold chain and vaccine management was poor. Similarly, the cold chain and vaccine management status was also poor. Therefore, on-site training should be provided to vaccine handlers to increase their knowledge, so as to improve their practices on cold chain and vaccine management. In addition, Programme based supportive supervision is needed to improve cold chain and vaccine management.
The contribution of knowing practice to the theory–practice ‘divide’ in global learning
Authors: Bullivant Andrea
Published: June 2022

This article draws on research exploring how practitioners in development education centres (DECs) in England conceptualise global learning and understand the relationship between theory and practice. It responds to ongoing critique that when it comes to practice, there is a lack of clarity and reflection on conceptual and theoretical issues, and their implications for what practitioners know and do. Informed by critical grounded theory, the research analysed data obtained through focus groups which were designed to engage practitioners in a process of reflecting on their work collaboratively and critically. While findings from an early analysis of responses appeared to support arguments about a weak theory–practice relationship, revisiting participants’ emphasis on what they do as practice prompted exploration of the literature on similar debates in wider professional contexts. This introduced insights centred on concepts of embodied and ‘knowing practice’. Applying these concepts back to the data supported evidence of a more complex and symbiotic relationship between theory and practice in some participants’ responses. This was significant in reframing the theory–practice divide assumed by the research aims, shifting the emphasis from knowledge to practice, and opening up questions about what knowledge and practice means in the context of DECs. It also empowered practitioners by alerting them to possibilities for engaging more actively with knowledge and transforming their practice collectively.
Trousseau Syndrome in a 25-Year-Old Woman with Occult Colon Malignancy, Lynch Syndrome, and Chronic Thromboembolic Pulmonary Hypertension
Authors: Matthews Caleb R. , Madison Mackenzie , Zhang Chen , Waters Joshua , Garcia Jose P. , Beckman Daniel
Published: June 2022

We present a rare case of thrombosis associated with an occult colon malignancy (Trousseau syndrome) in a 25-year-old woman who also presented with previously unidentified Lynch syndrome and acute-on-chronic thromboembolic pulmonary hypertension. Staged treatment included bilateral pulmonary endarterectomy under deep hypothermic circulatory arrest, followed 11 days later by laparoscopic subtotal colectomy and creation of a primary anastomosis. The patient tolerated both procedures well and recovered normal functional status. Final pathologic analysis of the resected colon mass revealed a pT3N0, stage IIA adenocarcinoma; no adjuvant therapy was administered. At her one-year follow-up visit, the patient was cancer-free, remained on lifelong apixaban anticoagulation, and was undergoing routine monitoring and genetic counseling. This case highlights the need for multidisciplinary management of a patient with severe chronic thromboembolic pulmonary hypertension and a concomitant malignancy.
The effects of L1, task, and classifier type in Chinese-L2 learners’ use of classifiers
Authors: Zhang Jiahuan , Gnevsheva Ksenia
Published: June 2022

This study explores three potential factors that influence Chinese L2 learners’ classifier use in a classroom setting: L1 background, task, and classifier type. We developed a picture-prompted test, including composition, free cloze, and multiple-choice cloze questions to elicit the use of classifiers. Participants were 50 Chinese L2 learners from Arabic, English, and Japanese L1 backgrounds. Although Japanese L1 participants performed numerically better than their Arabic and English counterparts, statistical analysis suggests that L1 was not a significant predictor of test performance. The composition task was shown to be conducive to the use of test-taking strategies, and it revealed a higher classifier accuracy than the more constrained multiple-choice task. Meanwhile, there was an interaction between L1 and task, suggesting that L1 influence may be conditioned by task type. Moreover, our logistic model predicts different levels of accuracy for classifier use by type, which potentially suggests a developmental path of acquiring classifiers licensed by the most prominent noun feature they are associated with, with shape being the earliest, followed by animate, inanimate, and concept.
Performance of four regression frameworks with varying precision profiles in simulated reference material commutability assessment
Authors: Markus Corey , Tan Rui Zhen , Lim Chun Yee , Rankin Wayne , Matthews Susan J. , Loh Tze Ping , Hague William M.
Published: June 2022

Objectives

One approach to assessing reference material (RM) commutability and agreement with clinical samples (CS) is to use ordinary least squares or Deming regression with prediction intervals. This approach assumes constant variance that may not be fulfilled by the measurement procedures. Flexible regression frameworks which relax this assumption, such as quantile regression or generalized additive models for location, scale, and shape (GAMLSS), have recently been implemented, which can model the changing variance with measurand concentration.

Methods

We simulated four imprecision profiles, ranging from simple constant variance to complex mixtures of constant and proportional variance, and examined the effects on commutability assessment outcomes with above four regression frameworks and varying the number of CS, data transformations and RM location relative to CS concentration. Regression framework performance was determined by the proportion of false rejections of commutability from prediction intervals or centiles across relative RM concentrations and was compared with the expected nominal probability coverage.

Results

In simple variance profiles (constant or proportional variance), Deming regression, without or with logarithmic transformation respectively, is the most efficient approach. In mixed variance profiles, GAMLSS with smoothing techniques are more appropriate, with consideration given to increasing the number of CS and the relative location of RM. In the case where analytical coefficients of variation profiles are U-shaped, even the more flexible regression frameworks may not be entirely suitable.

Conclusions

In commutability assessments, variance profiles of measurement procedures and location of RM in respect to clinical sample concentration significantly influence the false rejection rate of commutability.
Snoring induced reflux (SnoR) and a carcinoma in the gastro-oesophageal junction
Authors: Loske Gunnar
Published: June 2022

Little is known about the relationship between snoring and the development of carcinomas of the gastro-oesophageal junction. The aim of the paper is to draw attention to snoring induced reflux (SnoR) observed during a routine preoperative examination in a patient with AEG type II after neoadjuvant chemotherapy. During the examination the patient (body mass index 26.5) started to snore deeply. As a consequence, remarkable morphological-functional changes at the gastro-oesophageal junction became apparent. Reflux was periodically aspirated, accompanied by snoring on inspiration. In our patient, the carcinoma developed precisely at this point of contact. The phenomenon of SnoR is demonstrated in a video. SnoR could be an explanation for the described correlation between snoring and the occurrence of carcinomas in the gastro-oesophageal junction. Further studies on the phenomenon of SnorR could be of major interest for the understanding of AEG carcinomas. It is possible that new preventive measures can be derived from these findings.
Limited diagnostic value of questionnaire-based pre-participation screening algorithms: a “risk-exposed” approach to sports activity
Authors: Palermi Stefano , Sirico Felice , Fernando Fredrick , Gregori Giampietro , Belviso Immacolata , Ricci Fabrizio , D’Ascenzi Flavio , Cavarretta Elena , De Luca Mariarosaria , Negro Francesco , Montagnani Stefania , Niebauer Josef , Biffi Alessandro
Published: June 2022

Background

Several pre-participation screening algorithms (PPSAs) have been proposed to assess sports eligibility in different populations. They are usually based on self-administered questionnaires, without further medical assessment if no risk factors are documented. The Med-Ex “Formula Benessere” worksite program includes a complete cardiovascular (CV) screening for all participants. The purpose of this study was to assess PPSAs accuracy in detecting medical and/or CV abnormalities in the general population, comparing the results with the date derived from Med-Ex program.

Methods

The Med-Ex medical evaluation, consisting of medical history, physical examination (including body composition), resting electrocardiogram (ECG) and exercise stress test in 464 male subjects (38.4 aged) was analyzed and matched to several PPSAs – Physical Activity Readiness Questionnaire (PAR-Q) (2002–2020), American Heart Association (AHA)/American College of Sport Medicine (ACSM) (1998–2009–2014–2015), European Association of Cardiovascular Prevention and Rehabilitation (EACPR) (2011) – retrospectively simulated.

Results

Five-hundred and 67 abnormalities were detected though Med-Ex medical evaluation, and one-fourth (24%) would have been undetected applying PPSA alone. In particular 28% of high blood pressure, 21% of impaired fasting glycaemia, 21% of high Body Mass Index (BMI) values and 19% of ECG abnormalities would have been missed, on average, by all PPSAs.

Conclusions

The simulation analysis model performed in this study allowed to highlight the limits of PPSAs in granting sport eligibility, compared to a medical-guided CV screening. These findings emphasize the importance of a more balanced approach to pre-participation screening that includes a thorough evaluation of the cost/benefit ratio.
Low HDL-C is a non-fasting marker of insulin resistance in children
Authors: Zevin Erika L. , Peterson Amy L. , Dodge Ann , Zhang Xiao , Carrel Aaron L.
Published: June 2022

Objectives

Childhood obesity and associated comorbidities, including insulin resistance, are increasing in the United States. Our objectives were to (1) determine the prevalence of insulin resistance in children seen in dyslipidemia clinic and (2) evaluate which aspects of the lipid profile correlate with insulin resistance.

Methods

Children and adolescents seen in a specialized pediatric dyslipidemia clinic without secondary diagnoses known to alter the lipid panel were included. Simultaneous fasting lipid panel, insulin, and glucose levels were available in 572 children (50.5% male).

Results

Mean patient age was 15.0 ± 3.6 years with the majority being over 10 years of age (92.5%). Mean BMI was 29.8 ± 8.1 kg/m2 and BMI standard deviation score was 1.80 ± 0.9. Mean HOMA-IR was 6.2 ± 5.7 with a range of 0.4–49.3, and interquartile range of 2.7–7.6. Triglyceride level had a positive correlation with HOMA-IR (p<0.001). HDL-C negatively correlated with HOMA-IR even controlling for triglyceride level by multivariate analysis (p=0.001) and HDL-C <30 mg/dL predicted IR with 41.5% PPV.

Conclusions

In children and adolescents with dyslipidemia, insulin resistance is common and significantly correlates with reduced HDL-C levels. Non-fasting samples are easier to obtain in children and low HDL-C, which is minimally affected on non-fasting samples, could be an easily obtained indicator of IR. Increasing detection of insulin resistance in children with dyslipidemia may provide greater opportunities for lifestyle interventions and possible pharmacotherapy to modify cardiovascular risk.
On the Raising of the Finite Main Verb in Angolan Portuguese and in Mozambican Portuguese: Cartographic Hierarchies, Microvariation and the Use of Adverbs as Diagnostics for Movement
Authors: Tescari Neto Aquiles
Published: June 2022

This paper revisits the issue of verb raising in two closely related languages, namely Angolan Portuguese (AP) and Mozambican Portuguese (MP). Cinque’s (cartographic) hierarchy of adverbs is used to examine microvariation in these two varieties of Portuguese. The empirical data, gathered through experiments on acceptability rating tasks (to detect the position of the V(erb) in relation to adverbs) and cloze tests (to diagnose the adverbial classes which can be recovered by the elliptical VP), have been collected among university students in Luanda and Maputo, the capitals of Angola and Mozambique, respectively. The cutting points within the functional hierarchy where the V goes, be it mandatorily or optionally, are different in the two languages. In AP, the verb must raise past the frustrative aspect adverb (em vão/à toa‘in vain’), while in MP the verb must raise to the left of the singular completive adverb (tudo‘everything’). The main verb cannot raise past the AspTerminativeadverb (já não/não mais‘no longer’) in MP. In AP, it can optionally raise over the highest projection in the inflectional domain. Such a difference may explain the recovery of high adverbs in VP-ellipsis structures, only possible in AP. The corollary of the inter-linguistic study developed for Comparative Syntax is the adequacy of the cartographicdémarchewhen it comes to establishment of strict boundaries in the study of microvariation among closely related grammars.
The Reference to the Leasing of Land on Stela Krakow National Museum MNK-XI-999 from the First Intermediate Period
Authors: Demidchik Arkadiy
Published: June 2022

Our knowledge regarding the practice of land lease in Egypt of the III–II millennia BC still remains very patchy. To date, the oldest evidence of its existence are considered to be the Heqanakht letters from the Middle Kingdom. The article argues, however, that oblique references to it occurred as early as in the First Intermediate Period, and simply have not yet been recognized as such. In the autobiographical inscription of the overseer of butchers Merer, the collocation is being shown to be about land lease; Merer’s risk-management strategy against too low inundations was akin to that of Heqanakht. The situation reported in the inscription of the overseer of priests Rehui (Manchester 5052) is reminiscent of that described in the demotic literary story of Djedher (p British Museum EA 69532, ll. 6−9).
Versatzstücke eines Hymnus an den Sonnen- und Schöpfergott (O. Lg Ae BJF 31a, O. ANAsh.Mus. H.O. 302+342 etc. und Lied Nr. 100 des Großen Leidener Liederzyklus I 350)
Authors: Fischer-Elfert Hans-W.
Published: June 2022

The purpose of this communication is to show that the recently published ostracon Lg Ae BJF 31a in Basle/Switzerland carries fragments of a hymn to the sun- and creator god Amun-Re instead of a prayer. A couple of parallels on other ostraca and the collection of numerical hymns on pLeiden I 350 can be adduced to justify its attribution to the hymnic genre.