bluuebunny/crossref_metadata_2025 huggingface dataset:
How do question-answer exchanges among generations matter for children’s happiness?
Authors: Hirose Junichi
Published: June 2024

Intergenerational exchange plays an increasing role in realizing sustainable societies. Question-answer exchanges are the trigger for individuals to initiate some intergenerational relations, and the literature has established that inquisitiveness (curiosity about something and someone different) contributes to people’s generativity and happiness. However, little is known about how children’s inquisitiveness influences their generative concern and happiness. We claim that inquisitiveness is essential for children to enhance their happiness and hypothesize that those who receive a positive response from adults tend to be inquisitive and express the signs of generativity. To empirically examine the hypothesis, we have statistically characterized inquisitiveness in relation to adult-child interaction, generativity (offering care for people and the natural environment) and happiness, using the data from a survey of 511 Japanese children between 9 and 14 years and by applying the revised generativity concern scale (GCS-R). The results show that inquisitiveness correlates with generativity and happiness, primarily that a positive response by adults to children’s inquiries promotes their inquisitiveness through adult-child interactions. Our analysis shows that children’s inquisitiveness, encouraged by adults’ positive responses, is more significant in happiness than the generativity concern during childhood. Overall, the results suggest that adults responding positively to children’s questions is essential for promoting inquisitiveness and increasing happiness.
Bounding systems: A qualitative study exploring healthcare coordination between the emergency youth shelter system and health system in Toronto, Canada
Authors: Hudani Alzahra , Schwan Kaitlin , Labonté Ronald , Yaya Sanni
Published: June 2024

Background

Several youth staying at emergency youth shelters (EYSs) in Toronto experience poorly coordinated care for their health needs, as both the EYS and health systems operate largely in silos when coordinating care for this population. Understanding how each system is structurally and functionally bound in their healthcare coordination roles for youth experiencing homelessness (YEH) is a preliminary step to identify how healthcare coordination can be strengthened using a system thinking lens, particularly through the framework for transformative system change.

Methods

Forty-six documents, and twenty-four semi-structured interviews were analyzed to explore how the EYS and health systems are bound in their healthcare coordination roles. We continuously compared data collected from documents and interviews using constant comparative analysis to build a comprehensive understanding of each system’s layers, and the niches (i.e., programs and activities), organizations and actors within these layers that contribute to the provision and coordination of healthcare for YEH, within and between these two systems.

Results

The EYS and health systems are governed by different ministries, have separate mandates, and therefore have distinct layers, niches, and organizations respective to coordinating healthcare for YEH. While neither system takes sole responsibility for this task, several government, research, and community-based efforts exist to strengthen healthcare coordination for this population, with some overlap between systems. Several organizations and actors within each system are collaborating to develop relevant frameworks, policies, and programs to strengthen healthcare coordination for YEH. Findings indicate that EYS staff play a more active role in coordinating care for YEH than health system staff.

Conclusion

A vast network of organizations and actors within each system layer, work both in silos and collaboratively to coordinate health services for YEH. Efforts are being made to bridge the gap between systems to improve healthcare coordination, and thereby youths’ health outcomes.
Unrevealing the multitargeted potency of 3-1-BCMIYPPA against lung cancer structural maintenance and suppression proteins through pharmacokinetics, QM-DFT, and multiscale MD simulation studies
Authors: Alshehri Mohammed Ali , Asiri Saeed A. , Helmi Nawal , Baeissa Hanadi M. , Hamadi Abdullah , Alzahrani Abdulrahman , Alghamdi Rashed Mohammed , Rafeeq Misbahuddin M. , Alharbi Zeyad M. , Kamal Mohammad Azhar
Published: June 2024

Lung cancer, a relentless and challenging disease, demands unwavering attention in drug design research. Single-target drugs have yielded limited success, unable to effectively address this malignancy’s profound heterogeneity and often developed resistance. Consequently, the clarion call for lung cancer drug design echoes louder than ever, and multitargeted drug design emerges as an imperative approach in this landscape, which is done by concurrently targeting multiple proteins and pathways and offering a beacon of hope. This study is focused on the multitargeted drug designing approach by identifying drug candidates against human cyclin-dependent kinase-2, SRC-2 domains of C-ABL, epidermal growth factor and receptor extracellular domains, and insulin-like growth factor-1 receptor kinase. We performed the multitargeted molecular docking studies of Drug Bank compounds using HTVS, SP and XP algorithms and poses filter with MM\GBSA against all proteins and identified DB02504, namely [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid (3-1-BCMIYPPA) as multitargeted lead with docking and MM\GBSA score range from -8.242 to -6.274 and -28.2 and -44.29 Kcal/mol, respectively. Further, the QikProp-based pharmacokinetic computations and QM-based DFT showed acceptance results against standard values, and interaction fingerprinting reveals that THR, MET, GLY, VAL, LEU, GLU and ASP were among the most interacting residues. The NPT ensemble-based 100ns MD simulation in a neutralised state with an SPC water model has also shown a stable performance and produced deviation and fluctuations <2Å with huge interactions, making it a promising multitargeted drug candidate—however, experimental studies are suggested.
Self correction fractional least mean square algorithm for application in digital beamforming
Authors: Shah Syed Asghar Ali , Jan Tariqullah , Shah Syed Muslim , Raja Muhammad Asif Zahoor , Zafar Mohammad Haseeb , Haq Sana Ul
Published: June 2024

Fractional order algorithms demonstrate superior efficacy in signal processing while retaining the same level of implementation simplicity as traditional algorithms. The self-adjusting dual-stage fractional order least mean square algorithm, denoted as LFLMS, is developed to expedite convergence, improve precision, and incurring only a slight increase in computational complexity. The initial segment employs the least mean square (LMS), succeeded by the fractional LMS (FLMS) approach in the subsequent stage. The latter multiplies the LMS output, with a replica of the steering vector (Ŕ) of the intended signal. Mathematical convergence analysis and the mathematical derivation of the proposed approach are provided. Its weight adjustment integrates the conventional integer ordered gradient with a fractional-ordered. Its effectiveness is gauged through the minimization of mean square error (MSE), and thorough comparisons with alternative methods are conducted across various parameters in simulations. Simulation results underscore the superior performance of LFLMS. Notably, the convergence rate of LFLMS surpasses that of LMS by 59%, accompanied by a 49% improvement in MSE relative to LMS. So it is concluded that the LFLMS approach is a suitable choice for next generation wireless networks, including Internet of Things, 6G, radars and satellite communication.
Two hybrid flow shop scheduling lines with assembly stage and compatibility constraints
Authors: Muñoz-Sánchez Rafael , Martínez-Salazar Iris , González-Velarde José Luis , Ríos Solís Yasmín Á.
Published: June 2024

Two hybrid flow shop scheduling lines must be coordinated to assemble batches of terminated products at their last stage. Each product is thus composed of two jobs, each produced in one of the lines. The set of jobs is to be processed in a series of stages to minimize the makespan of the scheduling, but jobs forming a product must arrive at the assembly line simultaneously. We propose a mixed integer linear programming model. Then, based on the model, we propose a pull-matheuristic algorithm. Finally, we present two metaheuristics, a greedy randomized adaptive search procedure and a biased random key genetic algorithm, and compare all the methodologies with real-based instances of a production scheduling problem in the automobile manufacturing industry. The greedy algorithm yields high-quality solutions, while the genetic one offers the best computational times.
Application of the Sepsis-3 criteria to describe sepsis epidemiology in the Amsterdam UMCdb intensive care dataset
Authors: Williams Christopher Y. K. , Edinburgh Tom , Elbers Paul W. G. , Thoral Patrick J. , Ercole Ari
Published: June 2024

Introduction

Sepsis is a major cause of morbidity and mortality worldwide. In the updated, 2016 Sepsis-3 criteria, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, where organ dysfunction can be represented by an increase in the Sequential Organ Failure Assessment (SOFA) score of 2 points or more. We sought to apply the Sepsis-3 criteria to characterise the septic cohort in the Amsterdam University Medical Centres database (Amsterdam UMCdb).

Methods

We examined adult intensive care unit (ICU) admissions in the Amsterdam UMCdb, which contains de-identified data for patients admitted to a mixed surgical-medical ICU at a tertiary academic medical centre in the Netherlands. We operationalised the Sepsis-3 criteria, defining organ dysfunction as an increase in the SOFA score of 2 points or more, while infection was defined as a new course of antibiotics or an escalation in antibiotic therapy, with at least one antibiotic given intravenously. Patients with sepsis were determined to be in septic shock if they additionally required the use of vasopressors and had a lactate level >2 mmol/L.

Results

We identified 18,221 ICU admissions from 16,408 patients in our cohort. There were 6,312 unique sepsis episodes, of which 30.2% met the criteria for septic shock. A total of 4,911/6,312 sepsis (77.8%) episodes occurred on ICU admission. Forty-seven percent of emergency medical admissions and 36.7% of emergency surgical admissions were for sepsis. Overall, there was a 12.5% ICU mortality rate; patients with septic shock had a higher ICU mortality rate (38.4%) than those without shock (11.4%).

Conclusions

We successfully operationalised the Sepsis-3 criteria to the Amsterdam UMCdb, allowing the characterization and comparison of sepsis epidemiology across different centres.
Generating large-scale real-world vehicle routing dataset with novel spatial data extraction tool
Authors: Ali Hina , Saleem Khalid
Published: June 2024

This study delves into the critical need for generating real-world compatible data to support the application of deep reinforcement learning (DRL) in vehicle routing. Despite the advancements in DRL algorithms, their practical implementation in vehicle routing is hindered by the scarcity of appropriate real-world datasets. Existing methodologies often rely on simplistic distance metrics, failing to accurately capture the complexities inherent in real-world routing scenarios. To address this challenge, we present a novel approach for generating real-world compatible data tailored explicitly for DRL-based vehicle routing models. Our methodology centers on the development of a spatial data extraction and curation tool adept at extracting geocoded locations from diverse urban environments, encompassing both planned and unplanned areas. Leveraging advanced techniques, the tool refines location data, accounting for unique characteristics of urban environments. Furthermore, it integrates specialized distance metrics and location demands to construct vehicle routing graphs that represent real-world conditions. Through comprehensive experimentation on varied real-world testbeds, our approach showcases its efficacy in producing datasets closely aligned with the requirements of DRL-based vehicle routing models. It’s worth mentioning that this dataset is structured as a graph containing location, distance, and demand information, with each graph stored independently to facilitate efficient access and manipulation. The findings underscore the adaptability and reliability of our methodology in tackling the intricacies of real-world routing challenges. This research marks a significant stride towards enabling the practical application of DRL techniques in addressing real-world vehicle routing problems.
Assessing vegetation cover and valuing ecosystem services in southwestern Ethiopia: Implications for conservation
Authors: Yilma Zenebe Ageru , Yitay Bialfew Ashagrie
Published: June 2024

The Bench-Sheko zone, parts of the Eastern Afromontane Biodiversity Hotspot, is characterized by its rich biodiversity. However, recent reductions in vegetation cover have drawn concern, highlighting the critical role of remote sensing in monitoring these alterations is critical. Furthermore, this study evaluates the economic value of the ecosystem services rendered by the diverse types of vegetation cover class in the area. The classification of vegetation types and measuring their ecosystem benefits are crucial for monitoring vegetation and analyzing land cover changes. estimating the value of ecosystem services is vital for environmental impact assessments, cost-benefit analyses, and creating payment schemes for these natural services. For the vegetation cover map, it uses Sentinel-2 satellite data and a Random Forest classifier using Google Earth Engine. Based on a properly chosen reference, ecosystem service assessment approaches include benefit transfer, direct market value, and the social cost of carbon. The results highlight the vegetation classes’ enormous value and the services they offer. The largest value for Supporting Services (2829.3 USD ha⁻1yr⁻1) is found in the Remnant Forest, which makes up 30.98% of the total area. With the highest value for both cultural services (2847.7 USD ha⁻1yr⁻1) and regulatory services (5063.9 USD ha⁻1yr⁻1), the wetlands, which make up 4.35% of the total area, stand out. The total annual value of all ecosystem services provided by all vegetation classes is estimated to be 2.089 billion USD. When paired with methods for tracking and assessing changes in vegetation cover over time, high-resolution satellite images and precise classification algorithms can offer insightful information on the condition of the environment and support informed decision-making. In order to evaluate and convey to society and policymakers the advantages of vegetation cover, the value of ecosystem services is essential.
Beyond objective metrics: A comparative analysis of health care systems incorporating subjective dimensions to improve comparability of access and equity in healthcare assessments
Authors: Jaworeck Sandra
Published: June 2024

Comparing health care systems is important for several reasons. E.g. lower-resource health care systems can learn from higher-resource ones, and country-specific progress can be made. Previous rankings of health care systems have been based on objective factors such as the number of available hospital beds or health care spending. An index is considered here that includes a subjective level that is intended to represent access to the health care system. Therefore, this study investigates the divergence between subjective and objective indices related to health care expenditure, with a focus on the influence of involuntary and voluntary payments. Utilizing the Rational Choice Theory as a framework, it explores how individual preferences and perceived benefits affect these indices. The analysis reveals that social insurance contributions, which are mandatory and beyond individual control, are evaluated differently in subjective indices compared to objective indices. This discrepancy is less pronounced for voluntary expenditures, where individuals have decision-making power. The findings highlight significant variations in the correlations between macroeconomic health care indicators and the indices, emphasizing the critical role of autonomy in financial decisions related to health care.
Association between support of basic psychological needs and stress response as mediated by motivation for solitude
Authors: Takagi Gen , Shibata Michiaki , Nakagawa Yumi
Published: June 2024

This study examined the relationship between not self-determined / self-determined solitude and stress responses, as well as the effect of supporting / thwarting of basic psychological needs. The sample consisted of 606 Japanese people aged 20 years and older. We used a cross-sectional survey to measure their motivations for solitude, supporting / thwarting of basic psychological needs, and stress responses. Not self-determined solitude was negatively correlated with supporting of basic psychological needs and positively correlated with thwarting of basic psychological needs. In addition, a cutoff score of 16 for not self-determined solitude was found to be optimal for identifying individuals with a high stress response. Mediation analysis revealed that supporting / thwarting of basic psychological needs has direct effects on stress responses and indirect effects mediated by not self-determined solitude. These findings suggest that fostering environments that support basic psychological needs of autonomy, competence, and relatedness can alleviate not self-determined solitude and reduce stress responses.
Inhibitory activities of essential oils from Syzygium aromaticum inhibition of Echinochloa crus-galli
Authors: Ni Xianzhi , Bai Haodong , Han Jincai , Zhou Yong , Bai Zhendong , Luo Siquan , Xu Jingjing , Jin Chenzhong , Li Zuren
Published: June 2024

Echinochloa crus-galli is a serious weed species in rice paddies. To obtain a new potential bioherbicide, we evaluated the inhibitory activities of 13 essential oils and their active substances against E. crus-galli. Essential oil from Syzygium aromaticum (L.) Merr. & L. M. Perry (SAEO) exhibited the highest herbicidal activity (EC50 = 3.87 mg mL-1) among the 13 essential oils evaluated. The SAEO was isolated at six different temperatures by vacuum fractional distillation, including 164°C, 165°C (SAEO—165), 169°C, 170°C 175°C and 180°C. The SAEO—165 had the highest inhibitory rate against E. crus-galli. Gas chromatography-mass spectrometry and high phase liquid chromatography identified eugenol (EC50 = 4.07 mg mL-1), α-caryophyllene (EC50 = 17.34 mg mL-1) and β-caryophyllene (EC50 = 96.66 mg mL-1) as the three compounds in SAEO. Results from a safety bioassay showed that the tolerance of rice seedling (~ 20% inhibition) was higher than that of E. crus-galli (~ 70% inhibition) under SAEO stress. SAEO induced excessive generation of reactive oxygen species leading to oxidative stress and ultimately tissue damage in E. crus-galli. Our results indicate that SAEO has a potential for development into a new selective bio-herbicide. They also provide an example of a sustainable management strategy for E. crus-galli in rice paddies.
Gut microbiota diversity in a dung beetle (Catharsius molossus) across geographical variations and brood ball-mediated microbial transmission
Authors: Chen Hao-Yu , Wang Cheng-Ye , Zhang Bin , He Zhao , Yang Ren-can , Zhang Hong-hui , Hu Qing-quan , Zhao Zhi-Yong , Zhao Min
Published: June 2024

The dung beetle primarily feeds on the feces of herbivorous animals and play a crucial role in ecological processes like material cycles and soil improvement. This study aims to explore the diversity and composition of the gut microbiota of Catharsius molossus (a renowned dung beetle originating from China and introduced to multiple countries for its ecological value) and exploring whether these gut microbes are transmitted vertically across generations. Using 16S rRNA and ITS rRNA gene sequencing techniques, we described the diversity and composition of gut microbes in C. molossus from different localities and different developmental stages (Egg, young larvae and old larvae). We discovered that the diversity of gut microbiota of dung beetles varied obviously among different geographical localities and different developmental stages, and we also discussed the potential influencing factors. Interestingly, the microbial community structure within the brood balls is more similar to male dung beetle than to that of females, which is consistent with the observation that the brood ball is constructed by the male dung beetle, with the female laying egg in it at the final step. This unique breeding method facilitates offspring in inheriting microbial communities from both the mother and the father. Initially, the larvae’s gut microbiota closely mirrors that of the parental gift in these brood balls. As larvae grow, significant changes occur in their gut microbiota, including an increase in symbiotic bacteria like Lactococcus and Enterococcus. Analysis of the gut bacteria of adult dung beetles across various localities and different developmental stages identified nine core genera in adults, contributing to 67.80% of the total microbial abundance, and 11 core genera in beetles at different developmental stages, accounting for 49.13% of the total. Notably, seven genera were common between these two core groups. Our results suggest that Parental gifts can play a role in the vertical transmission of microbes, and the abundance of probiotics increases with larval development, supporting the hypothesis that "larval feeding behavior occurs in two stages: larvae first feed on parental gifts to acquire necessary microbes, then enrich symbiotic microbiota through consuming their own feces."
Patient preferences for models of care for fibromyalgia: A discrete choice experiment
Authors: Norwood Patrícia , Beasley Marcus , Stevens Martin , Hollick Rosemary , Macfarlane Gary , McNamee Paul ,   for the PACFiND Study Investigators
Published: June 2024

Background

Fibromyalgia is a common reason for referral to a rheumatologist and is a centralised pain state with symptoms beginning in adolescence/early adulthood and manifests as pain throughout the body, fatigue and cognitive dysfunction. Whilst there is considerable evidence on effective treatments, diagnosis and management are complex. There is almost no evidence on how to organise health services to deliver recommended therapies. The aim of the current study was to understand patient preferences for different features of healthcare services for fibromyalgia.

Methodology

We use the Discrete Choice Experiment Method (DCE), a choice-based survey that quantifies preferences for attributes of goods, services or policy interventions, to elicit preferences in relation to alternative models of care for people with fibromyalgia. In this study, attributes describe different models of care for fibromyalgia. We based attributes and levels on earlier phases of the PACFiND project and a literature review on fibromyalgia models of care. The final analysis sample consisted of 518 respondents who completed the survey in full.

Results

The final analysis sample consisted of 518 respondents ((patients living in the UK, over 18 years old, with a diagnosis of fibromyalgia), who completed the survey in full. The model of care most preferred is one characterised by earlier diagnosis and ongoing management by a Rheumatologist, via Face-to-face or Phone/video call appointments, with a stronger preference for the latter mode of support. The most preferred treatment was Medication, followed by Physical Therapy, with the least preferred being Talking Therapy. Relative to a Waiting Time for treatment of 6 months, respondents would prefer a lower Waiting Time of 3 months and dislike waiting 12 months for treatment. Respondents showed willingness to receive Ongoing Help and Advice by a Nurse Practitioner or a GP, instead of a Specialist Rheumatologist, provided they were compensated by other changes in the model of care.

Conclusion

This study has found that, although respondents express a preference for specialist care, provided by a Rheumatologist, they may be willing to trade-off this preference against other features within a model of care. This willingness to accept a different skill-mix (e.g., appointments with a GP or a Nurse Practitioner) has important implications for practice and policy, as this is a more feasible option in settings where the availability of specialist care is highly constrained.
The effect of core stability training on ball-kicking velocity, sprint speed, and agility in adolescent male football players
Authors: Sofuoğlu Ceyda , Güçhan Topçu Zehra , Bayrakcı Tunay Volga
Published: June 2024

This study was conducted to investigate the effect of core stability training program on ball-kicking velocity, running speed, and agility in adolescent male football players. To this end, 36 male football players aged 12–14 were divided into the training group and control group. Before implementing the core stability training program, participants’ ball-kicking velocity, sprint speed, and agility performance were measured with a Bushnell velocity radar gun, 20 m sprint test, and 505 agility test, respectively, in both training group and control group. After the measurements, the training group followed core stability training program three days a week, for eight weeks in addition to the routine training program, while the control group followed the routine training program only. Ball-kicking velocity, sprint speed, and agility performance were re-measured in both groups after the completion of the core stability training program. Significant improvements were detected in all parameters, i.e., ball-kicking velocity, sprint speed, and agility performance in the training group (p<0.05). On the other hand, in the control group, no significant change was detected in the ball-kicking velocity and sprint speed (p>0.05), whereas a significant improvement was observed in agility performance (p<0.05). Inter-group comparisons revealed statistically significant differences between the groups in ball-kicking velocity and sprint speed in favor of the training group (p<0.05), while no significant difference was found between the groups in agility performance (p>0.05). In conclusion, this study’s findings suggest that core stability exercises can be incorporated into the routine training program of adolescent male football players.
Governance in times of war: Public procurement in Ukraine
Authors: Klymak Margaryta , Vlandas Tim
Published: June 2024

Wars increase the importance of government functions, yet they also constrain their ability to fulfill these functions. In particular, wars hinder economic activity, thereby limiting governments’ capacity to raise the revenues required to maintain stability and meet the heightened needs of citizens. Effective governance is therefore severely undermined in times of war. However, empirical research on how wars affect government procurement is limited. We address this gap by exploring procurement dynamics using over one million public purchases of goods and services in Ukraine between January 2021 and October 2022, corresponding to the Russian invasion of the country. We document a large fall in the total number of purchases since the invasion and an increase in the share of successfully completed procurements. This higher success rate comes at the cost of efficiency, with the government paying more to source their goods. This can be attributed to the decline in the share of government purchases via online auctions and the reduced competition. Thus, the prioritization of the quick acquisition of goods and services forced governments to sacrifice cost-effectiveness. In summary, the war did not lower the successful purchasing of private goods and services, and transparency was not decreased. However, the trade-off of speed and transparency for greater costs may become increasingly problematic with the growing budget constraints resulting from the war. This article contributes to our understanding of the Ukrainian government choices during the early phase of the war. The results also highlight the importance of ensuring procurement efficiency and transparency when the war ends as reconstruction efforts will require substantial increases in government procurements.
Detection of hepatitis viruses in suspected cases of Viral Haemorrhagic Fevers in Nigeria
Authors: Salu Olumuyiwa Babalola , Akinbamiro Tomilola Feyikemi , Orenolu Remilekun Mercy , Ishaya Onyinye Dorothy , Anyanwu Roosevelt Amaobichukwu , Vitowanu Olubunmi Rita , Abdullah Maryam Abiodun , Olowoyeye Adenike Hellen , Tijani Sodiq Olawale , Oyedeji Kolawole Solomon , Omilabu Sunday Aremu
Published: June 2024

There have been several Viral Hemorrhagic Fever (VHF) outbreaks in Nigeria which remains a public health concern. Despite the increasing number of suspected cases of VHF due to heightened surveillance activities and growing awareness, only a few cases are laboratory-confirmed to be VHF. Routinely, these samples are only tested for Lassa virus and Yellow fever virus with occasional testing for Dengue virus when indicated. The aetiology of the disease in these VHF suspected cases in Nigeria which are negative for Lassa, Yellow fever and Dengue viruses remains a puzzle. Since the clinical features exhibited by suspected VHF cases are like other endemic illnesses such as Hepatitis, there is a need to investigate the diversity and co-infections of hepatitis viruses as differentials and possible co-morbidity in suspected cases of VHFs in Nigeria. A total of three hundred and fifty (350) blood samples of 212 (60.6%) males and 138 (39.4%) females, aged <1–70 years with a mean age of 25 ±14.5, suspected of VHFs and tested negative for Lassa, Yellow fever and Dengue viruses were investigated for Hepatitis A, B, C and E viruses at the Centre for Human and Zoonotic Virology (CHAZVY), College of Medicine, University of Lagos (CMUL) using serologic and molecular techniques. The serologic analysis of these VHF suspected cases samples revealed that 126 (36%) were positive for at least one hepatitis virus. Individual prevalence for each of the hepatitis virus screened for showed that 37 (10.6%), 18 (5.1%) and 71 (20.3%) were positive for HBV, HCV and HEV respectively. All the samples were negative for HAV. A co-infection rate of 11.9% was also observed, with HCV/HEV co-infections being the most prevalent and the Northern region having the greatest burden of infection. The evidence of hepatitis virus infections in suspected cases of VHF was documented. Thus, their associations as co-morbidities and/or mortalities in this category of individuals require further investigations in endemic countries such as Nigeria. Therefore, the possible inclusion of screening for hepatitis viruses and other aetiologic agents that could mimic infections in suspected cases of VHFs in Nigeria should be thoroughly evaluated to guide informed policy on the diagnosis and management of these cases.
Uncovering the knowledge gap: A web-based survey of healthcare providers’ understanding and management of dengue fever in East Azerbaijan, Iran
Authors: Abbasi Madineh , Zaim Morteza , Moosazadeh Mahmood , Alizadeh Mahasti , Dorosti Abbasali , Khayatzadeh Simin , Nikookar Seyed Hassan , Raeisi Ahmad , Nikpoor Fatemeh , Mirolyaie Abdolreza , Hokmabad Behrooz Naghili , Bazmani Ahad , Kaveh Farzad , Azimi Somayeh , Enayati Ahmadali
Published: June 2024

Background

Dengue fever (DF) is increasingly recognized as one of the world’s major mosquito-borne diseases and causes significant morbidity and mortality in tropical and subtropical countries. Appropriate and timely diagnosis and risk stratification for severe disease are crucial in the appropriate management of this illness. Healthcare providers (HCPs) play a key role in dengue fever diagnosis, management and prevention. The present study was conducted to determine the knowledge, attitudes and practices (KAP) among HCPs in East Azerbaijan Province, Iran.

Methods

A cross-sectional survey among 948 HCPs, using a structured questionnaire, was conducted in East Azerbaijan Province from May to July 2022. Data analysis was undertaken using descriptive methods, the Chi-square test or Fisher’s exact test, and logistic regression. A P-value <0.05 was considered for statistical significance.

Results

Out of the 948 (68.5% female) respondents, 227 were physicians and 721 were health professionals. The knowledge level of DF was found to be largely inadequate in the present study population (80.4%). The physician vs. health professional were a significant factor in differentiating attitude scores. The mean practice score regarding DF prevention and control measures among respondents was 8.40±1.97.

Conclusion

The findings call for urgent continuous education and training courses to increase KAP levels and increased capacity and capability for DF prevention and control. This is of outmost importance for the first point of care of DF patients.
Adoption of antithrombotic stewardship and utilization of clinical decision support systems—A questionnaire-based survey in Dutch hospitals
Authors: Graafsma Jetske , Klopotowska Joanna E. , Derijks Hieronymus J. , van de Garde Ewoudt M. W. , Hoge Rien H. L. , Kruip Marieke J. H. A. , Meijer Karina , Karapinar-Carkit Fatma , van den Bemt Patricia M. L. A.
Published: June 2024

Antithrombotics require careful monitoring to prevent adverse events. Safe use can be promoted through so-called antithrombotic stewardship. Clinical decision support systems (CDSSs) can be used to monitor safe use of antithrombotics, supporting antithrombotic stewardship efforts. Yet, previous research shows that despite these interventions, antithrombotics continue to cause harm. Insufficient adoption of antithrombotic stewardship and suboptimal use of CDSSs may provide and explanation. However, it is currently unknown to what extent hospitals adopted antithrombotic stewardship and utilize CDSSs to support safe use of antithrombotics. A semi-structured questionnaire-based survey was disseminated to 12 hospital pharmacists from different hospital types and regions in the Netherlands. The primary outcome was the degree of antithrombotic stewardship adoption, expressed as the number of tasks adopted per hospital and the degree of adoption per task. Secondary outcomes included characteristics of CDSS alerts used to monitor safe use of antithrombotics. All 12 hospital pharmacists completed the survey and report to have adopted antithrombotic stewardship in their hospital to a certain degree. The median adoption of tasks was two of five tasks (range 1–3). The tasks with the highest uptake were: drafting and maintenance of protocols (100%) and professional’s education (58%), while care transition optimization (25%), medication reviews (8%) and patient counseling (8%) had the lowest uptake. All hospitals used a CDSS to monitor safe use of antithrombotics, mainly via basic alerts and less frequently via advanced alerts. The most frequently employed alerts were: identification of patients using a direct oral anticoagulant (DOAC) or a vitamin K antagonist (VKA) with one or more other antithrombotics (n = 6) and patients using a VKA to evaluate correct use (n = 6), both reflecting basic CDSS. All participating hospitals adopted antithrombotic stewardship, but the adopted tasks vary. CDSS alerts used are mainly basic in their logic.
Capital structure, business model innovation, and firm performance: Evidence from Chinese listed corporate based on system GMM model
Authors: Tian Xu , Wang Yan , Kohar Umar H. A.
Published: June 2024

This paper aims to verify the impact of capital structure on business model innovation and firm performance and the mediating effect of business model innovation. We use the data of the Chinese growth enterprises market (GME) listed high-tech firms from 2016 to 2022 as a dynamic panel data model with the system–generalized method of moments (sys-GMM), adopting return on asset and earning per share as firm performance. Our results show that capital structure has a lag effect on firm performance. The total debt ratio in the last period has a significant non-linear impact on the performance and business model innovation level of nowadays, presenting a U-shaped relationship. The first-order lag short-term debt ratio positively improves firm performance. Business model innovation significantly promotes better firm performance, and business model innovation does exist in the mediating effect between enterprise capital structure and its performance. These results remain robust to different sample sizes or proxy variables. This paper proposes some suggestions for firm operations and government policies based on the findings.
Rice farmers’ preferences for seed quality, packaging, and source: A study from northern Bangladesh
Authors: Sarkar Md. Abdur Rouf , Habib Muhammad Ashraful , Sarker Mou Rani , Rahman Md. Mahbubur , Alam Sultanul , Manik Md. Nazmul Islam , Nayak Swati , Bhandari Humnath
Published: June 2024

The use of quality seeds is crucial to improve rice yield, food security, and farmers’ livelihoods. The large informal seed system, limited access to quality seeds, and low seed replacement rate challenge increasing rice yield. Despite robust government initiatives to support the seed system, progress has been slow. Besides, the need for farmers’ behavioural change, enhanced coordination, and communication at the local level has not received adequate attention. We investigate rice farmers’ preferences for quality seed, packet sizes, types, and sources, and assess the impact of utilizing good quality seed. We collected quantitative data from 1196 rice farmers in northern Bangladesh in 2019. To identify major factors influencing farmers’ preferences regarding quality seed, packet sizes, packet types, and seed sources, we employed ordered logit and multinomial logit models. Additionally, we used the propensity score matching procedure to assess the impact of good quality and formal seed sources on the rice yield. The findings revealed that farmers strongly prefer using seeds from formal sources despite limited accessibility. Of the total farmers, 34% use public source seeds, 33% use private source seeds, and the rest rely on their own saved seeds. The use of good quality seeds increased rice yields from the base yield by 0.07–0.28 t/ha. We found about a 48% gap in accessing good-quality seeds, indicating significant potential for scaling up the seed systems. Farmers using formal seed sources yielded 0.03–0.15 t/ha more than informal seed users. Farmers strongly prefer 5 kg packets due to their cost-effectiveness, easy storage, and handling convenience. Additionally, farmers prefer polycoated jute sacks for their versatility, multi-purpose applications, and resistance to pests. The econometric model results showed that farmers’ preferences were significantly influenced by gender, farm type, crop yield, seed price, market distance, various stakeholders’ advice, and seed supply systems’ constraints. The government should implement policies and programs to strengthen a well-connected seed network in rural areas, promoting inclusivity, and enhancing rice productivity. Besides, farmers’ needs and preferences should be considered in designing and implementing seed-related initiatives to foster sustainable agricultural development.
Ever-embodied arts and education
Authors: Kwon Hyunji
Published: June 2024

As an editor of this journal, I have the pleasure of presenting the editorial for this issue. Introducing the contents, I observe how the concept of embodiment or the connection between the body and the world, is embedded in all the works featured. From authors across the globe, the discourse of an ever-embodied and ever-evolving education through art is present, articulated through current practice and future visions of what is yet to come in arts education.
Children’s artistic expressions inspired by nature during early childhood garden pedagogy
Authors: Ruokonen Inkeri , Lepistö Jaana
Published: June 2024

The aim of this case study was to investigate how children learn about gardens and gardening through art; how they express their thoughts through visual expressions and stories. The research data include eleven drawings and stories from children about nature and gardening and were collected during the summer of 2021 in Finland’s only campus garden for teacher education. Additionally, six teachers were interviewed about their experiences with garden pedagogy. The data were analysed using descriptive thematic analysis. The findings include: the natural garden environment supports children’s creative thinking as expressed visually and verbally; children learn a great deal about nature and gardening and outdoor pedagogy in gardens can be integrated with play, excursions, imaginary thinking and knowledge related to natural environments. The positive findings underscore the imperative to implement arts-based garden pedagogy in Finland, which has diminished greatly in recent years.
Hopes, dreams and regrets: Exploring the power of metaphoric imagery
Authors: Chen Hsiao-ping
Published: June 2024

This study outlines a new approach to engaging students in artmaking within an undergraduate classroom by employing metaphors as artmaking strategies. Mark Ryden’s painting, The Apology, was used to teach preservice PK-6 education students how to derive meaning from art. Strategies of exploring students’ hopes, dreams and regrets indicate the importance of curriculum design focusing on students’ lived experiences and their social world. The study also offers examples of questions, creative inquiry and artmaking strategies that can be effectively integrated into students’ artmaking to foster deeper understanding and enhance conceptual thinking. Stories of students’ metaphoric images demonstrate how metaphor and imagery can be powerful tools for self-reflection and discovery as well as how teachers can develop art activities for and with students while empowering them to create a sense of self through art.
Visual essay of the performance El peso del pensamiento
Authors: Vidagañ María , Alonso-Sanz Amparo
Published: June 2024

Since the 1960s, performance has been one of the leading practices of feminist artists. This photo essay introduces our performance entitled El peso del pensamiento (2020–22). It denounces the cultural and symbolic violence suffered by women in academic environments through the legitimization and dissemination of gender-biased scientific and literary publications. The performance took place in 26 libraries at three public universities in the Autonomous Community of Valencia (Spain), namely ten libraries at the University of Valencia (UV), five at the Polytechnic University of Valencia (UPV), and eleven libraries at the Miguel Hernández University of Elche (UMH). Within the context analysed, we conclude that the weight of academic thought is decidedly masculine.
The Cancer Plot: Terminal Mortality in Marvel’s Moral Universe, Reginald Wiebe and Dorothy Woodman (2023)
Authors: Tiro Hana
Published: June 2024

Review of: The Cancer Plot: Terminal Mortality in Marvel’s Moral Universe, Reginald Wiebe and Dorothy Woodman (2023)

Edmonton: University of Alberta Press, 336 pp.,

ISBN 978-1-77212-711-9, p/bk, $39.99 CAD
Toxic effect of metals (Al, Cd, Pb, Cr, and Fe) in soybean experiment (Glycine max L.) IPRO technology
Authors: Silva Neto Jerônimo Luiz da , Sharma Porshia , Melo Aurélio Ferreira , Menezes Filho Antonio Carlos Pereira de , Ventura Matheus Vinícius Abadia
Published: June 2024

Soil contamination by heavy metals is a serious environmental and agricultural problem. Among the toxic metals, aluminum, cadmium, lead, chromium, and iron represent production problems for agriculture around the world. This study aimed to evaluate the tolerance to Al, Cd, Pb, Cr, and Fe in the vegetative phase of the NEO 790 IPRO cultivar. Different concentrations of 0, 35, 85, and 125 mg L-1 were prepared and added to the soil. The parameters evaluated were percentage of germination, plant length, root length, aerial and root fresh mass, and aerial and root dry mass. Al and Cd presented negative results for some vegetative parameters, being toxic at the concentrations evaluated. Positive effects were obtained for Pb and Cr on other morphological parameters, and for the Fe element, it was possible to observe double suitability as a toxic element in high doses (> 85 mg L-1) and in doses lower than 85 mg L-1 effect stimulator. The NEO 790 IPRO cultivar proved to be resistant in most of the parameters evaluated at the applied doses.
Stimulation of the calcium‐sensing receptor induces relaxations through CGRP and NK1 receptor‐mediated pathways in male rat mesenteric arteries
Authors: Carlton‐Carew Simonette R. E. , Greenberg Harry Z. E. , Greenwood Iain A. , Albert Anthony P.
Published: June 2024

Stimulation of the calcium‐sensing receptor (CaSR) regulates vascular contractility, but cellular mechanisms involved remain unclear. This study investigated the role of perivascular sensory nerves in CaSR‐induced relaxations of male rat mesenteric arteries. In fluorescence studies, colocalisation between synaptophysin, a synaptic vesicle marker, and the CaSR was present in the adventitial layer of arterial segments. Using wire myography, increasing external Ca2+ concentration ([Ca2+]o) from 1 to 10 mM induced vasorelaxations, previously shown to involve the CaSR, which were inhibited by pretreatment with capsaicin. [Ca2+]o‐induced vasorelaxations were partially reduced by the calcitonin gene‐related peptide (CGRP) receptor blockers, CGRP 8–37 and BIBN 4096, and the neurokinin 1 (NK1) receptor blocker L733,060. The inhibitory effect of CGRP 8–37 required a functional endothelium whereas the inhibitory action of L733,060 did not. Complete inhibition of [Ca2+]o‐induced vasorelaxations occurred when CGRP 8–37 and L733,060 were applied together. [Ca2+]o‐induced vasorelaxations in the presence of capsaicin were abolished by the ATP‐dependent K+ channel (KATP) blocker PNU 37883, but unaffected by the endothelium nitric oxide synthase (eNOS) inhibitor L‐NAME. We suggest that the CaSR on perivascular sensory nerves mediate relaxations in rat mesenteric arteries via endothelium‐dependent and ‐independent mechanisms involving CGRP and NK1 receptor‐activated NO production and KATP channels, respectively.
BOF steelmaking endpoint carbon content and temperature soft sensor model based on supervised weighted local structure preserving projection
Authors: Su YunKe , Liu Hui , Chen FuGang , Liu JianXun , Li Heng , Xue XiaoJun
Published: June 2024

Endpoint control stands as a pivotal determinant of steel quality. However, the data derived from the BOF steelmaking process are characterized by high dimension, with intricate nonlinear relationships between variables and diverse working conditions. Traditional dimension reduction does not fully use non-local structural information within manifold shapes. To address these challenges, the article introduces a novel approach termed supervised weighting-based local structure preserving projection. This method dynamically includes label information using sparse representation and constructs weighted submanifolds to mitigate the influence of irrelevant labels. Subsequently, trend match is employed to establish the same distribution datasets for the submanifold. The global and local initial neighborhood maps are then constructed, extracting non-local relations from the submanifold by analyzing manifold curvature. This process eliminates interference from non-nearest-neighbor points on the manifold while preserving the local geometric structure, facilitating adaptive neighborhood parameter change. The proposed method enhances the adaptability of the model to changing working conditions and improves overall performance. The carbon content prediction maintains a controlled error range of within ±0.02%, achieving an accuracy rate of 82.50%. The temperature prediction maintains a controlled error range of within ±10°C, achieving an accuracy rate of 79.00%.