bluuebunny/crossref_metadata_2025 huggingface dataset:
Open Surgical Obliteration of Three Indirect Carotid-Cavernous Fistulas
Authors: Kosarchuk Jacob , Patel Shrey , Dent Walter , Hedges Thomas , Malek Adel , Heilman Carl
Published: January 2024

BACKGROUND AND IMPORTANCE:

Carotid-cavernous fistulas (CCFs) are abnormal connections between the carotid artery and the cavernous sinus (CS). CCFs are primarily treated by an endovascular route, but there are situations in which a lesion is not amenable to endovascular or transorbital treatment, necessitating a transcranial approach. In this select group of patients, the use of crushed temporalis muscle to pack the CS fistula site was found to be an effective method for treatment of CCFs.

CLINICAL PRESENTATION:

In this case series, we present 3 patients with CCFs in which endovascular treatment was not possible because of occlusion of the petrosal sinuses or stenosis of the superior ophthalmic vein at the superior orbital fissure, rendering the lesion inaccessible by a transvenous or transorbital route. Each patient was treated with a variation of temporalis muscle packing through a skull base triangle; one was treated through the anteromedial triangle, one through the supratrochlear triangle, and the third through the Parkinson triangle. The fistulas were cured in each case.

CONCLUSION:

Cavernous-carotid fistulas that are not amenable to endovascular or transorbital treatment can be successfully treated by packing the CS fistula site with crushed temporalis muscle. To cure these patients' symptoms and enhance their quality of life, it is crucial to weigh the advantages and disadvantages of each therapy option.
Morphometric Comparison of Endoscopic Endonasal Transpterygoid and Precaruncular Contralateral Medial Transorbital Approaches to Sphenoid Sinus Lateral Recess
Authors: Bhuskute Govind S. , Gosal Jaskaran Singh , Alsavaf Mohammad Bilal , Abouammo Moataz D. , Manjila Sunil , Kandregula Sandeep , Nayyar Ashish K. , Jha Deepak K. , Carrau Ricardo L. , Prevedello Daniel M.
Published: January 2024

BACKGROUND AND OBJECTIVES:

The endoscopic endonasal transpterygoid approach (TPA), minimally invasive compared with the sublabial transmaxillary and transcranial approaches, still accounts for morbidity in benign lateral recess of sphenoid sinus (LRSS) pathologies. Others have suggested an alternative route to the LRSS, the endoscopic contralateral medial transorbital approach (cMTO). However, no quantitative evidence exists to support the clinical application of this approach. This cadaveric study, in a controlled laboratory setting, provides a morphometric comparison of the TPA and cMTO for accessing the LRSS. The study also details the anatomy and technical nuances for optimizing the cMTO corridor.

METHODS:

Ten fresh preinjected human cadaveric specimens (20 sides) were dissected with neuronavigation, completing endoscopic cMTO and TPA on each side. Four parameters—working distance to lateral recess, surgical exposure area, angle of attack (AoA), and surgical freedom—were measured for each approach. Relevant osteological measurements in 10 dried human skulls were recorded.

RESULTS:

The mean distance from the superior margin of the lacrimal sac impression to the inferior margin of the trochlear fossa was 10.29 ± 1.13 mm, and that from the anterior ethmoidal artery foramina to the posterior lacrimal crest was 9.63 ± 1.23 mm. The mean exposure area around the LRSS was significantly higher in TPA (614.09 ± 40.38 mm2) than in cMTO (391.19 ± 59.01 mm2, P = .001). The mean AoA was 9.83° and 10.24° in the cMTO and TPA, respectively, in the craniocaudal direction (P = .529). In the horizontal plane, it was 9.29° and 10.76° (P = .012). There was no significant difference in surgical freedom between the cMTO and TPA (804.61 and 806.05 mm3, respectively; P = .993).

CONCLUSION:

Although comparatively limited exposure area, the cMTO approach has a similar AoA and surgical freedom as TPA and offers better visualization and ergonomic advantages. cMTO provides a feasible, less morbid, multiport technique for benign sphenoid sinus lateral recess pathologies.
Nasal Injuries and Issues in Athletes
Authors: Escalona Tomas , Okamura Anthony Robert
Published: January 2024

Nasal injuries and issues are widespread in athletic populations and can adversely affect training, performance, and overall well-being. Causes can typically be understood as cellular (allergic, nonallergic, and infectious rhinitis) or structural (static vs dynamic obstruction, trauma), and diagnosis and management differ accordingly. Upper respiratory tract infections, a subtype of infectious rhinitis, remain the most common illnesses among athletes. Here, the authors review the research surrounding the complex relationship between exercise, immunology, and susceptibility to infection. Furthermore, the authors provide an updated understanding of the current literature surrounding rhinitis and nasal trauma management and synthesize practical treatment considerations for providers caring for athletes at all levels.
Incidence and prevalence of injuries in some sports – review
Authors: Gurau Tudor Vladimir , Musat Carmina Liana , Voinescu Doina Carina , Anghel Lucretia , Gurau Gabriela , Postelnicu Madalina Gabriela , Stefanescu Catalin Aurelian , Onu Ilie , Corciova Calin , Iordan Daniel-Andrei
Published: January 2024

: Injuries are an inherent risk associated with sports participation, impacting the health and performance of athletes across various disciplines. This review aims to provide a comprehensive analysis of the incidence and prevalence of injuries in selected sports, shedding light on the magnitude and patterns of injuries observed within each sport. To conduct this review, an extensive search was performed across electronic databases and relevant sports medicine literature. The findings reveal significant variability in injury rates and patterns among different sports. Sports such as football, handball, and volleyball, exhibit higher overall injury rates, with musculoskeletal injuries being most prevalent. Conversely, sports such as running, and cycling tend to demonstrate lower injury rates, with a focus on overuse injuries. Common injury types observed across sports include sprains, strains, fractures, contusions, and concussions, while body regions such as the lower extremities, head and neck, and upper limbs are frequently affected. Various factors contribute to the occurrence of injuries in sports, including player age, gender, skill level, training intensity, equipment usage, playing surface, and rule modifications. Contact and collision sports carry a higher risk of traumatic injuries compared to non-contact and individual sports. Understanding the incidence and prevalence of injuries in different sports is crucial for the development and implementation of injury prevention strategies. This review highlights the need for tailored approaches that address sport-specific risk factors, focusing on athlete education, proper training techniques, equipment modifications, rule changes, and enhanced medical support.
Effects of non-contact electric fields on kidney and liver histology in tumour-induced rats
Authors: Alamsyah Firman , Firdausi Nisrina , Nugraheni Subekti Evi Dwi , Fadhlurrahman Ahmad Ghitha , Nurhidayat Luthfi , Pratiwi Rarastoeti , Taruno Warsito Purwo
Published: January 2024

Background A novel modality of cancer treatment based on exposure to non-contact electric fields has been developed to reduce cancer incidence. However, the safety of the electric field exposure was not fully investigated. Therefore, This study aimed to observe the safety of electric field exposure on kidney and liver structures. Methods Female Sprague-Dawley rats were divided into one control group and three treatment groups. Animals were treated with 7,12-dimethylbenz[a]anthracene for mammary tumour induction and exposed to non-contact electric fields individually for 10 hours a day for three weeks. Fresh samples of the kidney and liver were collected for observation of structural damage in both organs. Both organs were prepared for histopathological cross-sectioning using the paraffin method and Hematoxylin and Eosin staining followed by histological scoring using the post-examination masking method. Results Damages found in the kidney were as follows: thickening of the Bowman capsule, karyolysis, karyorrhexis, pyknosis, cloudy swelling, epithelial sloughing, inflammation, haemorrhage, and congestion. In addition, the number of inflammation and haemorrhage in the kidney structure of healthy rats that were exposed to electric fields was significantly lower than that in the control group. All damages to the kidneys were also found in the liver, but each showed a different degree of damage. Exposure to this electric field can cause haemorrhagic damage to the livers of healthy rats, but not to rats with breast cancer. Conclusions Exposure to non-contact electric fields can cause haemorrhagic damage to the livers of healthy rats, however, in other liver tissues and the kidneys, exposure to this electric field was safe. It can even decrease the number of inflammations and haemorrhages in the kidneys.
COVID-19 anxiety and uncertainty of classes: Devastating effect on students’ academic behavior and performance
Authors: Kulal Abhinandan , Rahiman Habeeb Ur
Published: January 2024

Background The second wave of coronavirus disease 2019 (COVID-19) upsurged the level of anxiety among students and in addition to this, frequent closure of class, switching of teaching and learning to virtual added more agony to academic life. This study aimed to assess the impact of COVID-19 anxiety and uncertainty in class on academic performance moderated through academic behavior. Methods A structured questionnaire was developed to collect primary data and was distributed to 480 students using a systematic sampling technique. A structured equation model was developed and tested with a few hypotheses to answer the research objectives. A conceptual model was developed with the help of literature in order to understand causal relationship between study variables and tested with the help of the structured equation model. Results The study results showed that COVID-19 anxiety and uncertainty in classes negatively impacted students’ academic behaviour, which lead to students’ poor performance. The study identified that COVID-19 anxiety and uncertainty of class do not have a direct impact on academic performance; it only has an indirect negative impact on academic performance. Conclusions It can be concluded that uncertainty of classes during lockdown increased anxiety among students and it negatively impacted the academic behaviour of the students which lead to poor academic performance. The study helps the policymakers of the education sector to uplift the spirit of students in this pandemic situation and motivate the students to keep hope in their future careers; therefore, this study helps to fill that gap by contributing a working model.
Use of ivermectin and factors associated with the prevention and/or treatment of COVID-19: a cross-sectional online survey in the province of Chincha, Peru
Authors: Salvador-Carrillo Jose , Campos-Loza Luz , Guillen-Carbajal David , Osada Jorge , Zevallos Alejandra , Torres-Roman J. Smith
Published: January 2024

Background Peru has reported one of the highest mortality rates from COVID-19 worldwide. The Chincha province has been one of the most affected regions in Peru and the leading promoter of the use of ivermectin for the treatment of COVID-19. Therefore, our study aimed to evaluate the frequency of use and factors associated with the use of ivermectin for COVID-19 in Chincha. Methods A cross-sectional study was conducted during the second wave of COVID-19 in Peru. For statistical analyses, frequencies and percentages were reported. Prevalence ratios (PR) with a 95% confidence interval (CI), and a p-value of 0.05 were used to determine statistical significance. SPSS version 22 (IBM Corp) program was used for the analyses. Results A total of 432 participants were included in the study. A total of 67.6% (n = 292) of the participants used ivermectin during the COVID-19 pandemic. Of these, 20.20% (n=59) of the people used ivermectin for prophylactic purposes only, while 41.79% (n=122) used it as treatment for COVID-19 only, and 38.01% (n=111) used it for both reasons. The consumption of ivermectin was associated with being 50 years or older (PR:1.27, 95% CI:1.04–1.54), having a technical education level (PR:1.16, 95% CI:1.01–1.34), having had symptoms of COVID-19 with negative/no diagnosis (PR: 1.28, 95% CI: 1.07–1.53) or positive diagnosis (PR:1.38, 95% CI:1.18–1.61), or having had contact with infected people (PR:1.45, 95% CI:1.06–1.98). Conclusions Most people in Chincha used ivermectin during the second wave of the COVID-19 pandemic. The main factors associated with the use of ivermectin for the prevention/treatment of COVID-19 were age ≥50 years, having a technical education level, having had symptoms with negative/no diagnosis or positive diagnosis, and contact with people infected with SARS-CoV-2.
Whole body vibration and rider comfort determination of an electric two-wheeler test rig
Authors: Krishna Keerthan , Hegde Sriharsha , G T Mahesha , Shenoy B Satish
Published: January 2024

Background Two-wheeled vehicles are the major mode of transportation in India. Such vehicles are exposed to excessive vibration on the road when compared to four-wheeled vehicles. However, the research on the reduction of whole body vibration in the case of two-wheelers is not explored in detail. The present study predicts rider comfort in the case of an electric two-wheeler as per ISO 2631-1, by obtaining the finding the weighted acceleration at the strategic locations of vibration at the test rig. Methods An electric two-wheeler test rig is used in the study. The values of acceleration from the test rig in running conditions are obtained by using NI LabVIEW 2019. The drive cycle of the electric vehicle (EV) test rig is controlled by Sync sols’ EV lab software. Obtaining the weighted root mean square (RMS) acceleration from running the test setup, it is compared with the ISO 2631-1 standard to obtain the rider comfort. Results Loading area, traction motor, base mount, and suspension were found to be the strategic points of vibration. Frequency weighted RMS acceleration of 0.3 to 0.4 m/s2 obtained at these points are prone to cause discomfort for the rider. Vehicle speed, road profile, and duration of exposure were found to be important parameters affecting the rider’s comfort. A maximum of 4.6 m/s2 amplitude was observed. The loading area, which corresponds to a rider’s seat in actual vehicle, is important and reduction of these vibrations make the ride comfortable for the rider. Suspension and base mount of the test rig are found to be uncomfortable observing the weighted RMS acceleration. Conclusions A suitable damping technique design is very much essential in reducing these vibrations and improve the rider comfort, as many more non-deterministic vibrations are prone to cause dis-comfort in case of actual on road riding conditions.
Dietary knowledge assessment among the patients with type 2 diabetes in Madinah: A cross-sectional study
Authors: Alharbi Mashael , Alharbi Mansour , Surrati Amal , Alhilabi Mashael , alrashdi Ayed , Almokhalafi Majedah
Published: January 2024

Background There is a huge burden of nutrition-related non-communicable diseases, and diabetes is one of the leading chronic nutrition-related diseases affecting more than 500 million people globally. Collecting information regarding the awareness of dietary and nutrition knowledge among diabetic patients is the first step to developing a disease prevention program. Thus, this study primarily aims at assessing the dietary awareness of diabetes patients attending the diabetic centre in Madinah governorate, Saudi Arabia. Methods The study was started in November 2020 and ended in October 2021. The study participants (315) were type 2 diabetes mellitus (T2DM) patients attending a diabetic centre in Madinah, Saudi Arabia. A self-prepared dietary knowledge questionnaire (DKQ) was used in this research. The variables include balanced diet, food type, food choice, carbohydrate, protein, and fat. Knowledge score was, and the total score was levelled/categorized into ‘good’, ‘average’, and ‘poor’. Data were analysed by SPSS v.26. Results The study results identified the current knowledge of T2DM patients about different dietary items. The knowledge score of 62.2% of participants showed an average level of dietary knowledge, which is statistically significant. When we separately evaluated their understanding of different dietary components, we found that T2DM patients had poor knowledge of carbohydrates (30.15%), fat, food choices (47.7%), and type (34.6%). However, they had acceptable knowledge of proteins (56.5%). Conclusion Our participants exhibited acceptable knowledge about proteins but poorer knowledge of other food groups. A healthy, well-balanced diet is essential for excellent glycaemic control. Educating and arranging a health education program regarding dietary knowledge is recommended, specially designed for diabetic patients so that patients can opt for a healthier lifestyle
Morphometry of pyramidalis muscle and its role in reconstructive surgeries: A cadaveric study in South Indian population
Authors: Sumalatha Suhani , Rao Sharanya , Ankolekar Vrinda Hari
Published: January 2024

Background The pyramidalis muscle is a tiny triangular-shaped muscle that is located in the anterior abdominal wall, which originates from the body of the pubis and pubic symphysis and is inserted into linea alba. This study aimed to measure the different parameters of the pyramidalis muscle in adult cadavers. Methods This study was carried out on 31 adults (26 males and five females) 10% formalin embalmed cadavers of both sexes from the Department of Anatomy at Kasturba Medical College, Manipal. Results The mean length of the right pyramidalis muscle was 64.44 ± 12.52 mm and the left pyramidalis muscle was 64.73 ± 12.81 mm. The mean width of the muscle was 15 ± 4.18 mm and 15.03 ± 3.52 mm on the right and left sides, respectively. The mean thickness of the muscle was 1.32 ± 0.55 mm and 1.4 ± 0.80 mm on the right and left sides, respectively. The distance between the umbilicus to pubic symphysis ranged from 130–192 mm and their mean was calculated to be 159.77 ± 15.36. The distance between the umbilicus and the apex of the muscle ranged from 72–123 mm. Conclusions The measured parameters like length, width and thickness may help the surgeons to locate the muscle during infra umbilical surgeries.
Case Report: Management of pediatric Le Fort and mandibular fracture with a modified cap splint
Authors: Mathura Mrinalini , Bhola Nitin , Agarwal Anchal , Gupta Monica
Published: January 2024

Pediatric facial fractures are rare and make up 5–15% of all facial fractures. The low incidence of facial fractures among children is due to physiological and environmental factors such as greater resilience of the pediatric skeleton, higher bone to tooth ratio, direct parental supervision and limited outdoor activity.1 In children of 5–10 years of age nasal fractures are by far the most frequent (58.6%), followed by mandibular fractures (21.5%). Orbital (9.5%), frontal (5.1%), and midfacial (3.8%) fractures are next in frequency2. Le Fort fractures are very rare in children, and there is a paucity of literature presenting their frequency and characteristics. In the mandible condylar fracture is the most common (38.9%) followed by angle (20.6%), parasymphysis (18.3%), body (15.3%) and symphysis (5.3%).3 Facial fractures are more common in boys, though this varies greatly from 1.1:1 to 8.5:1.4

The majority of facial fractures in children result from falls (7.8–48%) and sports-related injuries (4.4–42%).5

In primary or mixed dentition, the placement of internal fixation hardware is challenging due to the risk of injuring unerupted permanent tooth follicles. The use of resorbable plates and screws offer a potential solution to the growing pediatric facial bone as the standard titanium fixation systems carry the risk of translocation, growth restriction, and dental injury. Dental splinting or suspension wires can also be used in place of direct plating. Fortunately, mild malocclusion at this age has the potential to be improved through bony remodeling, the eruption of permanent dentition, compensation of the mastication mechanism, and posttraumatic orthodontia.6

Accordingly, the goal of treatment is to restore the underlying bony architecture to its preinjury position in a stable fashion with minimal residual functional and esthetic impairment.
A protocol for a comparative evaluation of the fracture resistance of endodontically treated teeth reinforced with Cention N, resin-modified glass ionomer cement (RMGIC) and short fiber reinforced flowable composite as an intraorifice barrier
Authors: Jidewar Namrata , Chandak Manoj
Published: January 2024

Background: Endodontic treatment is the most common method for resolving pulpal and periapical pathology. However, various studies have reported that almost 11%–13% of all teeth that undergo extraction after endodontic treatment show the presence of cracks, craze lines, and vertical root fractures. Teeth with inadequate post endodontic restoration are more prone to fracture and coronal leakage, resulting in the diffusion of oral fluids, bacteria, bacterial products, and possibly root canal treatment failure. Furthermore, studies have advocated the use of endodontically treated teeth with restorative materials that have a similar or higher elastic modulus than the tooth for providing stiffness against forces that cause root fracture. Intraorifice barriers made of restorative materials that can bond to radicular dentin could thus be used to reinforce the radicular dentin while also preventing coronal microleakage. Although the sealing ability of intraorifice barriers has been widely compared in the literature, there have been few studies on the strengthening effect of the materials used in the study as intraorifice barriers when placed into the root canal. As a result, the current in vitro study aims to assess the effect of various materials as intraorifice barriers (Cention N, Resin modified glass ionomer cement, and short fiber reinforced flowable composite) on the force required fracture teeth after root canal treatment.

Methods:  This in vitro study will be done on extracted human mandibular premolars with single root canal where after doing root canal treatment 2-3 mm obturating material would be replaced by intra orifice barriers (Cention N, resin modified glass ionomer cement [RMGIC], and short fiber reinforced flowable composite). The force required to fracture teeth will be calculated using universal testing machine.
Evaluation and comparison of the effectiveness of kaleidoscope and virtual reality goggles to reduce dental anxiety in young children undergoing administration of local anesthesia.
Authors: Parakh Himani , Thosar Nilima
Published: January 2024

Administration of local anesthesia via injection is the main reason for inducing anxiety in children and if not intervened it aggravates the anxiety in subsequent appointments. There are many approaches, including pharmacological and non-pharmacological methods that can be used to reduce children’s perception of pain and anxiety. A frequently used non-pharmacological behaviour management method to reduce anxiety and procedure pain is distraction. The rationale of distraction is to shift the attention to avert the brain from receiving unwanted stimulus which induce anxiousness. Many approaches including music, television, portable video games, virtual reality (VR) helmet, and virtual reality audio-visual eyewear, have been implemented so far. Kaleidoscope and virtual reality goggles may help as distraction techniques in reducing the levels of anxiety caused during administration of local anesthesia. By the aid of which the operator may be able to make the dental experience child friendly and ultimately provide quality dental care to anxious children. Non pharmacological measures of reducing pain are cost effective and best means that can be used while performing dental procedures. This is a research protocol for a study aimed to evaluate and compare the effectiveness of kaleidoscope and virtual reality goggles to reduce dental anxiety in young children.
Evaluation for the efficacy of haemocoagulase agent (botroclot) as a pulpotomy material as compared to ferric sulfate- an animal study.
Authors: Karkare Swati , Thosar Nilima
Published: January 2024

Deciduous teeth are thought to be best space maintainers; thus efforts are made to preserve these teeth for as long as possible.  Grossly carious primary teeth should be restored and maintained which is the primary objective of “Pediatric dentistry”. Pulpotomy is done in the primary teeth where mechanical pulp exposure occurs during caries removal. All the functions of the radicular pulp are expected to be maintained by pulpotomy procedure. The main objectives are 1) managing reversible pulpal inflammation and keeping pulp in a vital condition. 2) maintain the function of the radicular pulp in deciduous teeth.  Success of Pulpotomy procedure is dependent on many factors, and the ability of the pulpotomy medicament being hemostatic is one of the most vital factors to maintain the vitality of the radicular pulp. Considering the limitations of commonly used pulpotomy medicaments for primary teeth i.e. Formocresol and also the disadvantages associated with the hemostatic Ferric sulfate, the present study will be carried out using hemocoagulase (“botroclot”) which has shown improved hemocoagulant properties in the medical field and for healing the extraction socket wounds. The available solution of hemocoagulase agent converted  in suitable Gel form will be tested for its tissue compatibility and hemocoagulant efficacy when used as pulpotomy material . The study will be conducted in two phases, I) Formulation of the gel and in vitro tests; II) Animal study to check histopathological effect on the pulp tissue as a pulpotomy agent.
Combating the devastating effects of cotton bollworm: case of Uzbekistan
Authors: Shokirova Gavharhon , Juraev Zuhriddin , Mirzayeva Mutabar
Published: January 2024

Bollworm poses a significant threat to cotton crops worldwide, including in the Fergana province of Uzbekistan. This study aims to explore innovative approaches to bollworm control and contribute to the global understanding of integrated pest management strategies (IPM). Using an extensive literature review and field observations, the study evaluates the effectiveness of an integrated protection system in reducing reliance on chemical inputs while increasing overall efficiency. The results highlight the multigenerational life cycle of bollworm, its impact on various crops, and the need for artificial biological control methods and targeted insecticide applications. In addition, the study highlights the need to adopt globally accepted IPM practices to ensure sustainable pest management. The findings underscore the importance of collaboration among researchers, farmers, policymakers, and industry representatives in developing and implementing advanced control measures. Through integrated approaches and the incorporation of scientific advances, bollworm infestations can be contained while safeguarding agricultural productivity and minimizing environmental risks. Preprint of this article is available at: https://www.preprints.org/manuscript/202306.1512/v1
A BRIEF EXPLORATION OF ARTIFICIAL INTELLIGENCE IN DENTAL HEALTHCARE: A Narrative review
Authors: Kamath Prakrati , Kamath Prathvi , Saldanha Sharon J R , Shetty Thilak  B , Rodrigues Shobha J , M Mahesh , Pai Umesh  Y , Hegde Puneeth K , Bajantri Prashant , Mukherjee Sandipan
Published: January 2024

Artificial intelligence is a computer system which can replicate human behavior and largely supports human actions and interpretation, but not replace human responses. Over the past few decades, the field of artificial intelligence (AI) has experienced phenomenal development and expansion. We are surrounded by several instances of AI. The most typical examples include Chat GPT, Alexa, Google Maps, autocorrect and text editors, e-payments, virtual travel booking agent, social media monitoring, gaming, including chess matches involving computers versus human chess masters, self driving cars, adaptive cruise control, parking assistance, and facial recognition for biometrics such as retinal scans and fingerprint scans. AI has applications in different branches of Dentistry. This review article attempts to highlight these points and lays an emphasis on how AI is driving dentistry in the present and will improve dental care in the future. A total of 59 papers from an electronic search using Google Scholar and PubMed were used to create this narrative review. Artificial intelligence can be utilised for diagnosis, decision-making, treatment planning, early detection and prevention of oral disease, and finally result prediction by utilising cutting-edge technology in imaging. It shows how dentists can use it as a useful tool at various phases of clinical cases. The future of AI in dentistry appears to be outstanding with advancements in full artificial intelligence technology, dental assistance, and dental instructional tools. In order to help dental professionals better grasp AI as a tool to assist their work with enhanced efficiency, investigations need to be done to uncover patterns and foresee future related to oral health concerns.
Pelvic pain symptoms and endometriosis characteristics in relation to oxidative stress among adolescents and adults with and without surgically-confirmed endometriosis
Authors: Shafrir Amy L , Wallace Britani , Laliberte Ashley , Vitonis Allison F , Sieberg Christine B , Terry Kathryn L , Missmer Stacey A
Published: January 2024

Background: While the majority of reproductive-aged females will experience pelvic pain during their lives, biological mechanisms underlying pelvic pain are not well understood. We investigated associations between pelvic pain symptoms and oxidative stress among people with and without surgically-confirmed endometriosis.

Methods: Using an enzyme-linked immunosorbent assay, we measured 8-Hydroxy-2’-deoxyguanosine (8-OHdG) in urine samples and corrected for creatinine levels in 434 surgically-confirmed endometriosis participants compared to 605 participants never diagnosed with endometriosis. At enrollment, participants reported details of their pelvic pain symptoms. Linear regression was used to compute geometric mean (GM) creatinine-corrected 8-OHdG levels with 95% confidence intervals (CI) among all participants and those with and without endometriosis separately, adjusting for potential confounders. Interactions by surgically-confirmed endometriosis status were tested by Wald statistics.

Results: No trends in 8-OHdG were observed among those with or without endometriosis for severity or frequency of dysmenorrhea, acyclic pelvic pain, dyspareunia or pain with bowel movements. Among endometriosis participants, lower 8-OHdG levels were observed for participants with any white, blue/black, or brown lesions (GM=76.7 versus 82.9 ng/mg; p=0.10), which was primarily driven by lower levels of 8-OHdG for any blue/black lesions (GM=72.8 versus 81.6 ng/mg; p=0.05).

Conclusion: While no associations were observed between 8-OHdG and pelvic pain symptoms, future research is needed to assess how other pathways of oxidative damage, e.g. through proteins or lipids, may affect endometriosis-associated symptoms. Additionally, further research is needed to understand differences in oxidative stress among endometriosis lesion sub-phenotypes.
A study of hearing acuity and health of the external auditory canal in earphone users
Authors: Ghoshmoulic Ayushi , Deshmukh Prasad
Published: January 2024

Noise-induced hearing loss as seen in today’s young generation is primarily due to long-duration exposure to personal listening devices like earphones, headphones, earbuds, and other different types of personal listening devices. With the rise in internet usage, online education as well as online gaming, the use of personal listening devices has increased fourfold. The exposure to noise above 85 dB for a long duration is the most common cause of reduced hearing acuity. Normally the earphones and headphones tend to produce the volume of 78 to 136 dB. Hence continuous exposure to such amplitudes may cause hearing loss especially in adolescents. However the new feature of noise cancellation in earphones and headphones is said to reduce the cases of noise induced hearing loss by decreasing the ambient noises, thus leading to better hearing in low volumes even in crowded or noisy places. It is also seen that with continuous usage of earphones there are increased incidences of otomycosis and increased cerumen production as well. This study aims to establish a relationship between hearing loss and affects on health of external auditory canal in earphone users if any.
Modified pull-through delayed hand-sewn coloanal anastomosis after laparoscopic total mesorectal excision
Authors: Bendib Hani , Djelali Nabil , Oukrine Hind , Chekman Chemseddine , Anou Abdelkrim
Published: January 2024

Background: Since its first description by Babcock in the 1930's, the pull-through delayed coloanal anastomosis (DCA) has lost interest in favor of the immediate coloanal anastomosis (ICA) with temporary stoma; especially with the advent of surgical stapling devices. In the last few years, there has been a renewed focus on DCA due to published favorable results, notably the reduced rate of anastomotic fistulas (AF) without the need for a stoma.

Some authors have brought some modifications to the original technique. In this article, we describe the modified delayed coloanal anastomosis (mDCA) as it is performed in the Department of Oncologic Surgery at the Debussy Clinic.

Methods: The mDCA consists on the one hand in shortening the pulled-through colonic stump, and on the other hand in performing a high anastomosis at the upper part of the anal canal.  

Results: This technique was successfully carried out in three patients with low rectal cancer. No AF was observed and diversion ileostomy was avoided in all patients.

Conclusions: The mDCA is a feasible and safe approach for the treatment of rectal cancer by minimal invasive surgery.
Effectiveness of dynamic neuromuscular stabilization, neurodevelopmental techniques and proprioceptive neuromuscular facilitation on trunk and gait parameters in patients with subacute stroke: A three-arm parallel randomised clinical trial
Authors: Udhoji Swadha P , Raghumahanti Raghuveer , Kovela Rakesh K
Published: January 2024

Background Today, stroke is the principal cause of demise in both developed and developing countries. There are different techniques used to treat patients with sub-acute stroke. Trunk muscles play a key role, i.e. in keeping the spine and trunk in place. This stabilization requires moving the head and extremities freely and selectively. The aim of this study is to compare the effectiveness of dynamic neuromuscular stabilization (DNS), neurodevelopmental techniques (NDT) and proprioceptive neuromuscular facilitation (PNF) on trunk and gait parameters in the subacute phase of stroke. This study is intended to ascertain the efficacy of all three approaches individually and to compare the effectiveness of DNS, NDT and PNF on trunk and gait parameters. Furthermore, the findings of this study could be used to assist post-stroke survivors in their early recovery and improve their level of independence. Methods In this interventional study, participants will be divided into three groups, and in each group, 20 patients will be assigned randomly to each group using the sequentially numbered opaque sealed envelope method. Group A patients will be given DNS, Group B will be given NDT, and Group C will be given PNF. The patients will be given treatment for five days for four consecutive weeks. Outcome measures that will be used are trunk impairment scale (TIS), dynamic gait index (DGI) and gait parameters. Data will be collected before and after the 4-week treatment period. Conclusions After the study, a conclusion will be drawn regarding which treatment technique is most suitable among all the three strategies for treating stroke patients if the hypothesis of the study is found valid. Clinical Trials Registry – India (CTRI) reference no. CTRI/2022/06/043037; date of registration 22/05/2022.
Effectiveness of Play Therapy Programme in Promoting Early Child Development of under-5 Children visiting Tertiary Care Hospital in Rural Settings: Study Protocol of a Randomized Controlled Trial.
Authors: Patil Manoj , Gaidhane Abhay , Quazi Zahiruddin
Published: January 2024

Background Good care and conscious, mindful parenting are the essential requirements of the early childhood period. Good care in early childhood consists of mindful handling of children’s needs like hunger, care in sickness, socio-emotional needs, safety, love and affection. Good care promotes children’s development and provides a favourable environment for learning. It’s a well-known fact that hospitalization is a stressful situation for child of any age. Play is an integral part of early childhood period which is virtually restricted in hospital settings. This study will try to explore the effectiveness of play therapy delivered in hospital settings, on early child development. Methods This will be a randomized control trial conducted in the Paediatrics department of a tertiary care hospital in Wardha, India. The sample size will be 360 children, 180 each in intervention and control arm. The hospitalized children from intervention arm will receive customized Play Therapy sessions from trained research assistants and will be followed up at scheduled home visits for one year from the date of enrolment. All children will be assessed for changes in cognitive, motor and socio-emotional development scores. The differences in development scores between intervention and control groups will be compared and effect sizes of changes will be calculated. Discussion Implementation of play stimulation activities have been reported as useful strategies for promoting child development and good recovery during hospitalization. This trial will attempt to explore the effectiveness of play therapy on changes in child development scores of children from intervention group compared to the control group. The customized play therapy program will be adapted to paediatric inpatient settings, and attempts will be made to improve the Play Therapy kit for hospitalized children. Registration Clinical Trial Registry of India Registration No.: C.T.R.I./2022/03/041355, dated 24/03/2022. Protocol Version: v5 Dated 05/09/2023.
Identification of pathogenic-specific open reading frames in staphylococci species
Authors: Farhan Fatima Naser , Zielezinski Andrzej , Karłowski Wojciech M
Published: January 2024

Background Bacteria within the Staphylococcus genus are notorious for causing a wide range of infections, and they possess genes that play a pivotal role in determining their pathogenicity. In this study, we characterized open reading frames (ORFs), which represent potential functional gene sequences, from selected staphylococcal genomes. Methods Our study involved the extraction, categorization, and annotation of ORFs using diverse analytical methods. This approach unveiled distinct ORFs in both pathogenic and non-pathogenic species, with some commonalities. To assess the conservation of these ORFs and their relevance to pathogenicity, we employed tblastn and Clustal Omega-Multiple Sequence Alignment (MSA) methods. Results Remarkably, we identified 23 ORFs that displayed high conservation among pathogenic staphylococci, with five of them extending beyond the Staphylococcus genus. These particular ORFs may encode products associated with RNA catabolism and could potentially function as regulatory small open reading frames (smORFs). Of particular interest, we found a single smORF situated within a conserved locus of the 50S ribosomal protein L1, present in 200 genomes, including 102 pathogenic strains. Conclusions Our findings highlight the existence of ORFs with highly conserved elements, proposing the existence of 23 novel smORFs that may play a role in the pathogenicity of Staphylococcus species.
Household resilience of women migrant worker sellers of Jamu Gendong
Authors: Diniyati Dian , Widiyanto Ary , Sanudin Sanudin , Fauziyah Eva , Achmad Budiman , Suhaendah Endah , Hani Aditya , Muhtar Muhtar , Danarti Danarti , Widyaningsih Tri Sulistyati , Winara Aji , Najiyati Sri , Dewi Rukmini Nugroho
Published: January 2024

Background The selling of Jamu Gendong (an Indonesian traditional herbal medicine), is closely associated with the informal work of women who migrate to different regions. In Sukoharjo Regency and Wonogiri Regency, Central Java Province, the pressing need to meet household necessities in their places of origin compels women to assume the role of breadwinners. Therefore, this research aimed to identify the livelihood capital and resilience of migrant women selling jamu gendong. Methods The study was conducted in Ciamis Regency, West Java Province, Indonesia, in November 2022, using quantitative and qualitative methods. Primary data were collected through structured questionnaires and in-depth interviews. The sample comprised 51 women selected through snowball sampling and actively involved in selling Jamu Gendong, along with six key individuals from relevant agencies. Results The results showed that the households of migrant women selling jamu gendong survived and adapted to the migration destinations to prevent poverty. This was attributed to the livelihood strategy of business diversification. In this context, migration was exclusively practiced by women without family members who rented accommodation together. This research identified different forms of capital these women possess, including their productive age and skills in preparing jamu gendong, physical capital encompassing road infrastructure, marketplaces, access to health and education facilities, and natural, social, and financial capital. Conclusions The findings contribute to a comprehensive understanding of the resilience demonstrated by migrant women selling jamu gendong. However, further research should be conducted in areas beyond the city center to obtain a holistic view of their resilience.
Characterization of four digestates from different types of substrates used in biogas production in Northern Peru
Authors: Rascón Jesús , Juarez Contreras Lily del Pilar , García Saldaña Euler Willan , Gosgot Angeles Wildor , Huanes Milton A. , Taramona Ruiz Luis Alberto , Barrena Gurbillon Miguel Ángel
Published: January 2024

Background Biol is one of the best-known digestates, which occurs during anaerobic digestion in biodigesters to generate biogas, using animal manure and vegetable waste. This digestate type is used in organic agriculture due to its easy application, contributing simultaneously to the circular economy and food security. Methods The objective of this study was to characterize four types of biol, generated in four anaerobic biodigesters for biogas production implemented in northern Peru fed with manure: i) pig manure; ii) cattle manure; iii) horse manure; iv) cattle manure with coffee processing water. All the biodigesters implemented had the same design but worked under different environmental conditions. Descriptive and multivalent statistics were applied to the data obtained for the parameters evaluated. Results The biols obtained had different nutritional compositions, depending on the type of substrate used. The biol from pig manure was characterized by high concentrations of bacteria, the one from cattle manure had low concentrations of nutrients in general, the one from horse manure was rich in salts, and the one from cattle manure with coffee processing water was rich in organic matter. Conclusions These results showed that all the biols obtained can be used for organic agriculture. However, their selection will depend on the nutritional requirements of the type of crop and soil where the biols are to be applied.
Association of maternal mental health on development and growth of children under two years old from Wardha: Protocol for a cross-sectional study
Authors: Handa Alisha , Gaidhane Abhay , Quazi Zahiruddin , Chaudhari Sonali
Published: January 2024

Background A mother’s mental health is crucial in shaping the early years of her child’s development and growth. Many mental health conditions can have an impact on pregnant and postpartum mothers. Postpartum anxiety, postpartum depression, and postpartum psychosis are a few mental health conditions that can affect the mother and child if not catered to at the right time. A mother’s mental health can lead to childhood delays in milestones, language development and growth. This study intends to examine the way various aspects of mothers’ mental health, like depression and stress, can influence the early developmental trajectories and physical growth of young children. Protocol A cross-sectional study with 196 participants will be conducted. Eligibility criteria includes mothers with children under two years old. Data will be collected using a semi-structured questionnaire. Maternal mental health will be assessed using validated measures, including standardised questionnaires. Established developmental assessments and anthropometric measurements will evaluate child development and growth. Conclusions The findings of the study shall help in planning appropriate interventions to reduce the association of maternal mental with childhood delay in development and growth.
The readiness of the Asian research ethics committees in responding to the COVID-19 pandemic: A multi-country survey
Authors: Karbwang Juntra , Torres Cristina E. , Navarro Arthur M. , Wongwai Phanthipha , Jimenez Edlyn B. , Shetty Yashashri , Ramalingam Sudha , Koli Paresh , Amir Lisa , Rachmawati Septi Dewi , Waworundeng Monalisa , Rizki Harnawan , Noor Asyraf Syahmi Mohd , Ghimire Prakash , Gyanwali Pradip , Sharma Subhanshi , Ghimire Namita , Wanigatunge Chandanie , Yimtae Kwanchanok
Published: January 2024

Background COVID-19 is a highly challenging infectious disease. Research ethics committees (RECs) have challenges reviewing research on this new pandemic disease under a tight timeline and public pressure. This study aimed to assess RECs’ responses and review during the outbreak in seven Asian countries where the Strategic Initiative for Developing Capacity in Ethical Review (SIDCER) networks are active. Methods The online survey was conducted in seven Asian countries from April to August 2021. Two sets of online questionnaires were developed, one set for the chairs/secretaries and another set for the REC members. The REC profiles obtained from the REC members are descriptive in nature. Data from the chairs/secretaries were compared between the RECs with external quality assessment (SIDCER-Recognized RECs, SR-RECs) and non-external quality assessment (Non-SIDCER-Recognized RECs, NSR-RECs) and analyzed using a Chi-squared test. Results A total of 688 REC members and 197 REC chairs/secretaries participated in the survey. Most RECs have standard operating procedures (SOPs), and have experience in reviewing all types of protocols, but 18.1% had no experience reviewing COVID-19 protocols. Most REC members need specific training on reviewing COVID-19 protocols (93%). In response to the outbreak, RECs used online reviews, increased meeting frequency and single/central REC. All SR-RECs had a member composition as required by the World Health Organisation ethics guidelines, while some NSR-RECs lacked non-affiliated and/or layperson members. SR-RECs reviewed more COVID-related product development protocols and indicated challenges in reviewing risk/benefit and vulnerability (0.010), informed consent form (0.002), and privacy and confidentiality (P = 0.020) than NSR-RECs. Conclusions Surveyed RECs had a general knowledge of REC operation and played a significant role in reviewing COVID-19-related product development protocols. Having active networks of RECs across regions to share updated information and resources could be one of the strategies to promote readiness for future public health emergencies.