bluuebunny/crossref_metadata_2025 huggingface dataset:
APLIKASI PERSAMAAN DIFERENSIAL PADA PENYEBARAN PENYAKIT BERBASIS SOFTWARE MAPLE UNTUK SISWA SMA NEGERI 3 AMBON
Authors: Beay Lazarus Kalvein , Wattimena Abraham Zacaria , Lesnussa Yopi Andry , Rahakbauw Dorteus Lodewyik
Published: June 2024

Persamaan diferensial telah menjadi salah satu topik matematika yang menarik pada kemajuan ilmu pengetahuan dan teknologi. Salah satu bentuk aplikasinya, yaitu pada penyebaran penyakit menular. Pada kenyataannya, pembelajaran matematika di sekolah masih bersifat teoritis, sehingga pembelaran bermakna sulit tercapai.  Materi matematika yang diberikan oleh guru sulit untuk dipahami oleh siswa karena bersifat abstrak. Hal ini mendorong pembelajaran untuk mengaplikasikan materi tentang persamaan diferensial pada kehidupan nyata di sekitar siswa. Selain itu, pesatnya kemajuan ilmu pengetahuan dan teknologi menuntut adanya kemampuan adaptasi dari siswa, guru, dan sekolah. Melalui kegiatan pengabdian ini, upaya adaptasi terhadap perkembangan ilmu pengetahuan dan teknologi dilakukan melalui peningkatkan kualitas pembelajaran pada SMA Negeri 3 Ambon. Kegiatan yang dilakukan meliputi upaya meningkatkan kemampuan siswa tentang penerapan materi persamaan differensial pada kehidupan nyata.  Pada akhirnya, Software Maple digunakan untuk mendukung proses pembelajaran matematika.
Pendidikan Perdamaian untuk Anak Usia Dini di Tengah Budaya Kekerasan
Authors: Kristianto Paulus Eko
Published: June 2024

Abstract. This article discusses an alternative offer to deal with the culture of violence that occurs around early childhood. Therefore, early childhood slowly needs to be made aware of a culture of violence and strategies for dealing with it simply according to the conditions and whereabouts of the child. This proposal uses the foundation of peace education studies. Thus, this article discusses peace education for early childhood amidst a culture of violence. The author used library research related to peace education, early childhood, and a culture of violence. This research showed that peace education has the potential to provide an alternative to dealing with a culture of violence. Indeed, it should be acknowledged that the study of peace education for early childhood is said to be minimal and urgently introduced early on, so this is expected to be a comprehensive conceptual breakthrough.Abstrak. Artikel ini membahas tawaran alternatif menghadapi budaya kekerasan yang terjadi di sekitar anak usia dini. Anak usia dini secara perlahan perlu disadarkan adanya budaya kekerasan dan strategi mengatasinya secara sederhana sebagaimana sesuai dengan kondisi dan keberadaan anak. Alternatif ini menggunakan pijakan kajian pendidikan perdamaian. Dengan kata lain, artikel ini membahas pendidikan perdamaian untuk anak usia dini di tengah budaya kekerasan. Metode penelitian yang penulis gunakan yaitu penelitian pustaka terkait pendidikan perdamaian, anak usia dini, dan budaya kekerasan. Penelitian ini menunjukkan bahwa pendidikan perdamaian berpotensi memberikan alternatif menghadapi budaya kekerasan. Memang, patut diakui bahwa kajian pendidikan perdamaian untuk anak usia dini dikatakan minim dan urgen dikenalkan sejak dini sehingga hal ini diharapkan dapat menjadi terobosan kebaruan konseptual yang komprehensif.
Analisis Bibliometrik: Penerapan Pedagogi Genre pada Pembelajaran Bahasa
Authors: Safi'i Imam , Sofiar Elly , Hikmat Ade
Published: June 2024

Genre Pedagogy is a text-based learning model. The learning process in the curriculum in Indonesia is to present language learning activities that refer to the Genre Pedagogy model. Articles that have been published contain many genre pedagogical models used in foreign language and non-language learning. Why was this research carried out? Looking at the digital-based conditions and times related to strong literacy skills in understanding various types of text. The aim of the research is to review literature related to the application of genre pedagogical learning models that use technology or are digitally based. The research method used is analysis or bibliometric methods sourced from Scopus and Crossref metadata using the Publish or Perish application. Based on searches and analysis using the Publish or Perish search system, it can be seen that there has not been a single study that specifically links it to digital-based Indonesian language learning. Thus, research is still needed on the application of digital-based genre pedagogy to Indonesian language learning.
Penerapan Model Pembelajaran Project Based Learning (PjBL) pada materi Energi Terbarukan di SMAN 3 Pandeglang
Authors: Suhartini Heni
Published: June 2024

The results of the 2023 SMAN 3 Pandeglang education report card show that literacy skills are in the Medium category (44.44% of students have achieved minimum competency) meaning that 40% - 70% of students have achieved minimum competency for reading literacy but efforts need to be made to encourage more students in achieve minimum competency.The use of the PjBL learning model is expected to increase social interaction between students and achieve higher student learning outcomes compared to competitive learning or individualistic learning which usually occurs. Most of the teaching and learning activities at SMAN 3 Pandeglang still use the lecture method or are not PjBL based.Based on the explanation above, it is necessary to carry out an in-depth study of improving students' scientific literacy abilities through the application of the Project Based Learning (PjBL) learning model on Renewable Energy material at SMAN 3 Pandeglang.
Representation of the Librarian in the Character of Urano Motosu in the Anime Ascendance af a Bookworm
Authors: Meilinda Eka , Prasetyawan Yanuar Yoga
Published: June 2024

Purpose Research. The librarian profession has often been underestimated. Several studies regarding the media that represents librarians depict the profession negatively. Positive representation is needed to depict the ideal figure of a librarian to reduce the developing negative stereotypes of librarians. This research aims to identify the representation of librarians in the character Myne (Urano Motosu), the main character with a high librarian spirit who carries out her duties as a church librarian. Research Methods. The research method used is Roland Barthes' semiotics. Result.  This research shows that Myne's appearance as a librarian uses a vintage style, no glasses, and half-space bun hair. Myne is described as having a superior character as a librarian and can represent the ideal librarian figure. Myne's librarian's weakness is that she has low social experience. However, over time, he was able to adapt and finally eliminate these shortcomings.  Conclusions. Myne represents the ideal librarian so that librarians and librarian professional organizations can use her as a role model. Keywords: Representation; librarian; semiotics; anime
Freud and Judaism
Authors: Ruin Hans
Published: June 2024

Review of Risto Nurmela: Sigmund Freud und sein Bekenntnis zum Judesein in ’Der Mann Moses und die monoteistische Religion’. Wien: Lit Verlag, 2023.
Um mestre dos elevadores e dos funiculares: engenheiro Mesnier du Ponsard
Authors:   Universidade de Coimbra, Murtinho Vitor
Published: June 2024

Mesnier du Ponsard foi, indelevelmente, um dos precursores dos transportes ferroviários em Portugal, destacando-se o seu trabalho no campo dos meios de locomoção mecânicos urbanos com o objetivo de vencer grandes diferenças altimétricas. Nesse sentido, a notoriedade do seu trabalho deve-se sobretudo à audácia das suas propostas de elevadores e de funiculares, contribuindo deste modo para a melhoria da mobilidade sustentada de algumas cidades nacionais. Estas propostas eram de iniciativa, normalmente, privada e tinham como princípio oferecer ligações cómodas entre zonas urbanas com acentuados desníveis e de acessibilidade condicionada.
Analysis of Risk Factors for Skin Disease Symptom at The Waste Disposal Workerin Deli Serdang
Authors: Sekar zahroh Diajeng ayu , Siregar Putra Apriadi , Utami Tri Niswati
Published: June 2024

Disease risks associated with waste collection and transportation work include skin health problems, increased cases of diarrhea, and skeletal muscle disorders. These circumstances will support the risk of developing skin diseases in waste  disposal workers. The purpose;of this study was to determine the relationship between length of service, use of Personal Protective Equipment (PPE), and personal hygiene with symptom of skin diseases among waste transport workers in Deli Serdang. This study is a quantitative study with a cross-sectional design. The sample amounted to 41 people with the sampling technique, namely total sampling. The research instrument was conducted by interview using a questionnaire and conducting field observations to observe waste transportation activities. Data analysis using univariate and bivariate, the statistical test used is the Chi-Square test. The results of research conducted on the relationship between the working period, the use of Personal Protective Equipment (PPE), and personal hygiene in waste transport workers in Deli Serdang, shows that workers who experience skin disease symptom are 41.5%. Based on the results of the chi-square analysis, it was found that there was a signicant relationship between the working period and symptom of skin diseases in waste transport workers where the value (pvalue=0.001), personal hygiene value (p-value=0.012), the use of Personal Protective Equipment (PPE) value (p-value=0.014). Conclusion: Based on the results of the study it can be concluded that there is a relationship between tenure, PPE, personal hygine with complaints of skin diseases in waste carriers. Waste haulers who have less than 5 years of service, compliant use of PPE, and good personal hygine are not at risk for skin disease complaints.

 

Keywords:  Personal Hygiene, Personal Protective Equipment (PPE), Work Period
Relationship between Knowledge Level and Cadre Attitudes About the Independent Care Program for the Use of Acupressure
Authors: Agustian Arya Brain , Suswardany Dwi Linna
Published: June 2024

Traditional health services that have been provided by health service facilities have an important purpose in highlighting disease problems in society, but public awareness in implementing independent care does not yet exist. Therefore, this research aims to determine the relationship between the level of knowledge and attitudes of cadres towards the self-care program using acupressure. The method used in this research is quantitative with a cross-sectional approach. This research was carried out in the working area of the Kartasura Community Health Center, namely in Ngadirejo Village and Pucangan Village in February 2024 with a population of 159 people. This study used non-probability sampling with a total sampling technique with a total of 159 respondents in accordance with inclusion and exclusion. Data collection was carried out using a questionnaire which was filled out directly by the respondent. The questionnaire has gone through validity and reliability tests before being used. The data analysis used in this research is descriptive analysis in the form of frequency distribution and chi-square test. Data analysis was carried out using the SPSS application. The chi-square test shows that there is a significant relationship between cadre knowledge and cadre attitudes towards the self-care program using acupressure in the Kartasura Health Center working area, especially Ngadirejo Village and Kartasura Village with a p-value of 0.031 < α 0.05. The conclusion is that the average cadre has a good level of knowledge and attitude towards the self-care program using acupressure. So with this program researchers have succeeded in increasing cadres' understanding of the acupressure method as part of independent care to increase knowledge of the benefits of acupressure in reducing disease problems in the community. Suggestions for cadres who have poor knowledge scores are that they can increase their knowledge scores by diligently participating in training held by the Kartasura Community Health Center.

 

Keywords :  Acupressure,  Education, Attitude
A BIBLIOMETRIC REVIEW OF NATURALIST ENVIRONMENTAL EDUCATION, 1937–2023
Authors:   Faculty of Design and Architecture, University Putra Malaysia, Selangor, Malaysia, LIU Xie , HUSSEIN Mohd Kher ,   Faculty of Design and Architecture, University Putra Malaysia, Selangor, Malaysia, BIN MAT NOOR Mohd Sallehuddin ,   Faculty of Design and Architecture, University Putra Malaysia, Selangor, Malaysia
Published: June 2024

The significance of naturalist environmental education (NEE) which primarily focuses on human-nature relationships lies in its ability to mitigate detrimental influences on environmental quality and foster environmental awareness, thereby averting adverse ecological consequences. Through a bibliometric examination of the literature using Scopus, this research attempted to chart and evaluate the intellectual production associated with NEE. The findings are based on a statistical analysis of 1553 documents using the VOSviewer software. Results indicate there has been a significant increase in global scholarly focus on NEE and the pattern of publications trend follows a four-stage progression. "Social Sciences" has the greatest number of relevant articles. Keywords including education literacy and sustainable development are of utmost importance. There is clear evidence of global scientific collaboration among developed countries. It's crucial for scholars to prioritize interdisciplinary collaboration within NEE, and enhance adult environmental literacy on developing countries.
STRATEGY FOR THE PREVENTION OF WORLD WARS IDEAL POLITICAL MAP OF THE WORLD, FROM 195 TO 21 MEGA-FEDERATIONS
Authors:   University of Craiova, Doctoral School of Sciences, Field of Geography, 13st, Alexandru Ioan Cuza St., 200585, Craiova, Romania, DIACONESCU Luca , NECȘULEA Angelica ,   University Babeș-Bolyai of Cluj-Napoca, Doctoral School History, Civilization, Culture, 1st, Mihail Kogălniceanu St., 400084, Cluj-Napoca, Romania
Published: June 2024

Wars have always caused millions and millions of dead, destroyed peoples' wealth and held development back. Geopolitics, alternative history, futurology or nationalist politics tackle this problem by creating regional paintings, but the results are low compared to expectations, the war due to border disorder is still intense. This research aims to develop a conceptual framework, based on five principles: historical, linguistic, religious, cultural and geopolitical, through which to create a theoretical direction, a map of the world close to the ideal IPMW (Ideal Political Map of the World). The concept of megastates, economically and nationally stable, such as: Brazil, the United States, China, Russia, India or the European Union currently existing, can expand worldwide, materializing in 21 countries with large areas and large populations, encouraging globalization, trade, free movement but above all an optimal framework of the balance of power.
RESULTS OF LOCAL ELECTIONS IN HARGHITA COUNTY, SEPTEMBER 27, 2020
Authors:   School of Advanced Studies of the Romanian Academy, Doctoral School of History and Archaeology, George Barițiu Institute of History, Cluj-Napoca, Romania, TOFAN George-Bogdan , NIŢĂ Adrian ,   Babeș-Bolyai University, Faculty of Geography, Gheorgheni Extension, Romania
Published: June 2024

The results of the local elections in Harghita County, 27th September 2020. This study aims to faithfully depict the territorial distribution of the electoral decisions taken by the inhabitants of Harghita County at the local elections held on 27th September 2020. Based on official statistical data from the Central Electoral Office (https://locale2020.bec.ro/rezultate), the voting for mayors, local and county councilors, as well as president of Harghita County Council was thoroughly examined. 67 mayors were elected in the 21st Electoral District ‒ Harghita County, their political affiliation being as follows: DUHR (48), SDP (7), HAT (5), IC (5), FHP (1) and NLP (1). Of the 835 local councilor seats, most were won by DUHR (570), followed by HAT (138), SDP (49), NLP (34), FHP (14), CI (13), PMP (8), SRU-LUSP (3), PRO ROMÂNIA (2), while the Magyar Civic Party, National Unity Block, Humanist Power Party (Social-Liberal) and the Liberal and Democrat Alliance won a single seat each. Harghita County Council is comprised of 30 county councilors (with one less seat than in the 2016-2020 legislature), 19 being DUHR members, 4 HAT, 3 SDP, 2 FHP and 2 NLP. Borboly Csaba, the DUHR candidate, received a total of 69 822 votes (64.54% of the votes), thus winning his fourth term as president of Harghita County Council.
ANEURISMA GIGANTE DE VEIA RENAL SECUNDÁRIO A FÍSTULA ARTERIOVENOSA IDIOPÁTICA: RELATO DE CASO E REVISÃO DE LITERATURA
Authors:   Hospital Agamenon Magalhães, Castanha de Albuquerque Neto Carlos , Ferreira Von-Sohsten Walter Joaquim , de Aguiar Guedes Rodrigo Augusto , Bandeira Mendes Costa Tiago , Pereira Carneiro de Albuquerque Maria Eduarda , Cabral de Sousa Jullyan , Ribeiro Grangeiro Sarah Ellen , Lemos Maia Rafaela , de Oliveira Buril Gabriela
Published: June 2024

Introdução: A fístula arteriovenosa é uma conexão direta entre uma artéria e uma veia. Uma fístula arteriovenosa renal idiopática é uma lesão rara (3-5% dos casos). Ademais, uma condição raramente descrita é a dilatação aneurismática venosa secundária ao alto fluxo sanguíneo imposto pela fístula arteriovenosa renal idiopática, alteração essa pouco relatada na literatura com sete casos identificados nessa revisão e publicados em lígua inglesa. Relato de caso: Este caso descreve um homem de 59 anos, hipertenso e portador de fibrilação atrial de baixa resposta ventricular com queixa de dores abdominais há 1 ano. Foi realizada ultrassonografia de abdômen total que evidenciou uma dilatação vascular renal a direita, lesão essa confirmada e detalhada por angiotomografia computadorizada de abdômen total. Diante das imagens, confirmou-se uma comunicação arteriovenosa renal com formação de aneurisma venoso medindo 6,5 centímetros no seu maior diâmetro. E o calibre da artéria renal após a comunicação arteriovenosa apresentava grande diferença para o diâmetro pré comunicação. Assim, foi optado por tratamento endovascular através de embolização da comunicação arteriovenosa com cola de cianoacrilato a 30% diluído com lipiodol® . Após a terapêutica instituída, com 48 horas, o paciente obteve alta hospitalar sem complicações e com função renal normal. Conclusão: Tanto o tratamento endovascular como o cirúrgico podem ser utilizados com bons resultados. No entanto, tendo em conta a escassez de dados publicados, desconhecem-se os resultados a longo prazo. Palavras-chave: Fístula Arteriovenosa. Aneurisma. Embolização Terapêutica.
HÉRNIA TRAUMÁTICA DA PAREDE ABDOMINAL: RELATO DE CASO E REVISÃO DA LITERATURA
Authors:   Universidade Federal do Paraná, Pessole Biondo-Simões Maria de Lourdes , Contin Mansur Alexandre , Waldraff Teixeira Henrique , Ayumi Teixeira Catarina , Lorenzi Daniela Thais ,   Complexo Hospital do Trabalhador
Published: June 2024

Introdução: A hérnia traumática da parede abdominal é caracterizada pela ruptura da musculatura e dos fáscias musculares da parede abdominal sem que haja solução de continuidade com a pele, levando à herniação do conteúdo abdominal. São incomuns e frequentemente associados a traumas com mecanismo de alta energia. Incidem em 0,17% a 0,90% dos pacientes com traumas abdominais. A preocupação com a busca de lesões intraperitoneais, faz com que sua identificação no primeiro momento seja frequentemente negligenciada. Por ser pouco frequente não se tem uma recomendação padronizada quanto ao momento da abordagem e mesmo qual a técnica ideal para seu reparo. Relato de caso: Os autores relatam uma paciente que sofreu acidente com colisão moto-auto. Não foi identificada a lesão de imediato e a mesma retornou um ano após com volumosa hérnia. Conclusão: O objetivo é alertar para a busca destas rupturas quando de traumatismos contusos sobre a parede abdominal. Palavras-chave: Hérnia. Parede abdominal. Traumatismo Múltiplo.
Paul Ricoeur filósofo del derecho: el sujeto de derecho y de responsabilidad como homme capable
Authors: Gorgoni Guido
Published: June 2024

En la última fase de la obra de Ricoeur, el ámbito jurídico se convierte en un punto central para la reflexión sobre la identidad y las capacidades del self, en lo que el sujeto realiza plenamente las capacidades como sujeto de derecho entendido como sujeto responsable en tanto que capaz de imputación reflexiva, adquiriendo así un espesor ético y antropológico ajeno a las categorías jurídicas de la subjetividad y la imputabilidad. El sí como sujeto de derecho despliega todo su potencial teórico en relación con una idea de responsabilidad orientada de manera prospectiva, es decir, en contraposición a la perspectiva "estática" de la atribución de derechos y deberes. La cuestión de la identidad del sujeto de derecho es abordada por Ricoeur desde la perspectiva de las condiciones concretas de su realización en relación con el otro, entendido en su doble forma interpersonal e institucional (en la doble figura del tú y de cada uno). Pero es solo enfrentándose a poderes reales y derechos concretos que el sí accede al estatuto de "verdadero sujeto de derecho", afirma Ricoeur, asì que la autonomía, de ser un supuesto teórico-dogmático en la base de la teoría de la subjetividad jurídica, se articula dentro de la cuestión de la ipseidad y la capacidad de auto-designación del sujeto como responsable, convirtiéndose también en una tarea cuya realización es incierta, caracterizando así  al sujeto del derecho como eminentemente vulnerable. Pero la vulnerabilidad donde se habla aquí está vinculada no solo con la fragilidad del cuerpo humano y con las asimetrías físicas: es la vulnerabilidad a la méconnaissance  que marca la constitución interpersonal del sujeto de derecho, y en este sentido no es necesariamente antitética a la autonomía, como marca del carácter interpersonal dentro del cual las relaciones con el otro se adquieren y se mantienen. Las capacidades del sí tienen que ser inscriptas en contextos sociales que estructuren la experiencia, es decir, lo legal y lo político, para que el sí pueda acceder al estatus de ciudadano, no solo desde el punto de vista de su reconocimiento por parte del sistema, sino también, y crucialmente, desde el punto de vista de su propia comprensión y la de los otros ciudadanos, ya que la igualdad y la reciprocidad en los derechos son solo una parte, aunque relevante, de un proceso de reconocimiento más amplio que va más allá del reconocimiento de un estatus igualitario a los sujetos por parte del sistema jurídico. En otras palabras, la cuestión de la autonomía y de la responsabilidad del sujeto de derecho se pone en relación con individuos concretos, cuya identidad no puede ser confinada únicamente a una forma jurídica.
Literatur Review: Pengaruh Media Sosial terhadap Industri Pariwisata dari Perspektif Destinasi dan Wisatawan
Authors: Kenyo Kharisma Kurniasari  , Eki Melina Widanti  , Atika Nur Hidayah
Published: June 2024

Artikel ini bertujuan untuk mengkaji sejauh mana dampak media sosial terhadap industri pariwisata, terutama dari sudut pandang wisatawan, pengelola destinasi, dan pemasar sebagai pemangku kepentingan pariwisata yang paling bergantung pada media sosial. Pesatnya pertumbuhan teknologi memudahkan wisatawan dalam memperoleh informasi sebelum melakukan perjalanan. Pada saat yang sama, mereka juga menjadi penghasil informasi dengan membagikan pengalaman wisata mereka melalui media sosial. Akibatnya, destinasi dengan strategi media sosial yang lebih baik dapat memperoleh jumlah pengunjung yang berlebihan. Oleh karena itu, pergeseran tren ini perlu dibarengi dengan perencanaan dan regulasi pariwisata yang tepat dengan tujuan menjaga aktivitas pariwisata selalu ramah dan menghindari pariwisata berlebihan di satu lokasi. Selain itu, pemahaman tentang perilaku wisatawan terkait dengan konsumsi media sosial akan membantu pengelola destinasi dan pemasar dalam meningkatkan penggunaan media sosial di masa mendatang.
Kata kunci: media sosial, industri pariwisata, destinasi wisata, persepsi wisatawan
DEVELOPMENT OF PROJECT-BASED LEARNING E-BOOK: A CASE STUDY FROM ACCOUNTING BILINGUAL CLASSES IN INDONESIA
Authors: Kartikasari Nungki , Hudaya Robith , Rizki Novia , Hanani Tri
Published: June 2024

This article aims to develop an e-book based on Project Based Learning needs in the Basic Accounting course for Bilingual Classes. The type of research used is research and development. The research model used in this study is the modified ADDIE method, which consists of 5 stages: analyzing, designing, developing, evaluating, and implementing. The data collection in this research includes collecting material from credible sources, then arranging it according to the order of the material in the Semester Learning Plan, and using an attractive design. Design validation is carried out by media experts and material experts. The validation results show a good value where this e-book is suitable for use. Design revisions are only limited to minor revisions and these revisions are based on validation forms from media experts and material experts, such as consistent use of terms, additional discussions, and additional report examples. Small group trials have also been carried out and found that the basic accounting electronic book value is suitable for use.
Traducción al español, adaptación transcultural y validación de la escala ADTC (Atopic Dermatitis Control Tool)
Authors: Caviedes Mariana Paula , Angles María Valeria , Luna Paula Carolina , Terrasa Sergio , Vazquez Peña Fernando , Echeverria Cristina , Larralde Margarita , Mazzuoccolo Luis Daniel
Published: June 2024

El cuestionario ADCT (Atopic Dermatitis Control Tool) permite objetivar en forma breve y autoadministrada la repercusión de la dermatitis atópica (DA) sobre la vida cotidiana de quien la padece. OBJETIVOS: Obtener una versión validarla en una población de adultos con DA. METODOLOGIA: 1) Traducción al español y adaptación transcultural del cuestionario a partir de la versión original en inglés, a través de un proceso de siete pasos. 2) Evaluación de la unidimensionalidad de la escala resultante mediante un análisis factorial exploratorio (AFE), de su confiabilidad mediante el coeficiente alfa de Cronbach, y de su validez mediante la evaluación de la correlación de su puntaje con los de los cuestionarios POEM y DLQI (criterios externos de referencia). RESULTADOS: La versión resultante del proceso de traducción y adaptación transcultural fue bien comprendida por la población blanco. El AFE de los 66 cuestionarios documentó la unidimensionalidad de la escala a partir del cumplimiento de todos los criterios utilizados para su verificación. Su confiabilidad fue excelente (Alfa de Cronbach: 0,917) y su puntaje tuvo muy alta correlación con los criterios de referencia externos (POEM: Spearman’s Rho 0,85; p < 0,0001; DLQI Spearman’s Rho = 0,81; p < 0,0001). CONCLUSION: La versión traducida al español y adaptada transculturación del cuestionario ADCT tiene características psicométricas apropiadas, lo que contribuirá a optimizar los procesos de cuidado de pacientes de habla hispana.
Fertility Preservation for Young Women with Breast Cancer: Review and Perspective
Authors: Zheng Shuxin , Cai Limei , Miao Zhiming , Yang Yinlong
Published: June 2024

Objectives: Breast cancer is a common malignancy that poses a significant danger to women. Recently the risks of breast cancer have been increasing in younger populations, and treatments may affect the ability to conceive, requiring options for fertility preservation. The clinical management of breast cancer typically involves surgery, chemotherapy, and radiotherapy, all of which may present detrimental effects on fertility. Thus, it is crucial to consider fertility preservation when formulating treatment plans. Mechanism: A narrative review was conducted to analyze the available literature regarding the impact of breast cancer treatment modalities on fertility, as well as strategies for fertility preservation. Findings in Brief: Various breast cancer treatment modalities can result in varying degrees of damage to a patient’s ovaries, potentially compromising their ovarian function and subsequently affecting their fertility. This article reviews various fertility preservation methods, including oocyte and embryo cryopreservation, controlled ovarian stimulation (COS), in vitro maturation (IVM), cryopreservation, and ovarian tissue transplantation. Additionally, we discuss several potential strategies, such as 3D bioprinting, Traditional Chinese Medicine (TCM), and Artificial Intelligence (AI) assisted treatment. Conclusions: The impact of breast cancer treatment modalities and fertility preservation strategies exhibits individual variability, necessitating the clinical selection of treatment based on the specific circumstances of each patient. The integration of 3D bioprinting, TCM, and AI is expected to provide a new perspective for young breast cancer patients seeking to maintain their fertility.
An Apoptosis-Related Specific Risk Model for Breast Cancer: From Genomic Analysis to Precision Medicine
Authors: Li Zhenghang , Liu Haichuan , Zhang Mingzhu , Wang Jianwei , Peng Qiling , Jiang Ning , Wei Yuxian
Published: June 2024

Background: Breast cancer (BC) ranks as the most prevalent malignancy affecting women globally, with apoptosis playing a pivotal role in its pathological progression. Despite the crucial role of apoptosis in BC development, there is limited research exploring the relationship between BC prognosis and apoptosis-related genes (ARGs). Therefore, this study aimed to establish a BC-specific risk model centered on apoptosis-related factors, presenting a novel approach for predicting prognosis and immune responses in BC patients. Methods: Utilizing data from The Cancer Gene Atlas (TCGA), Cox regression analysis was employed to identify differentially prognostic ARGs and construct prognostic models. The accuracy and clinical relevance of the model, along with its efficacy in predicting immunotherapy outcomes, were evaluated using independent datasets, Receiver Operator Characteristic (ROC) curves, and nomogram. Additionally, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses were used to predict potential mechanical pathways. The CellMiner database is used to assess drug sensitivity of model genes. Results: A survival risk model comprising eight prognostically relevant apoptotic genes (PMAIP1, TP53AIP1, TUBA3D, TUBA1C, BCL2A1, EMP1, GSN, F2) was established based on BC patient samples from TCGA. Calibration curves validated the ROC curve and nomogram, demonstrating excellent accuracy and clinical utility. In samples from the Gene Expression Omnibus (GEO) datasets and immunotherapy groups, the low-risk group (LRG) demonstrated enhanced immune cell infiltration and improved immunotherapy responses. Model genes also displayed positive associations with sensitivity to multiple drugs, including vemurafenib, dabrafenib, PD-98059, and palbociclib. Conclusions: This study successfully developed and validated a prognostic model based on ARGs, offering new insights into prognosis and immune response prediction in BC patients. These findings hold promise as valuable references for future research endeavors in this field.
Analysis of Related Factors Influencing Hypertension Classification among Centenarians in Hainan, China
Authors: Li Jing , Bi Jingfeng , Yang Shanshan , Wang Shengshu , Yang Shuwen , Chen Shimin , Han Ke , Luo Shengdong , Jiang Qiyu , Liu Miao , He Yao
Published: June 2024

Background: As a population ages, blood pressure levels gradually increase, leading to a higher incidence of hypertension and increased cardiovascular diseases risk. This study examines factors affecting hypertension grading among centenarians in the Hainan Province. Methods: Data from 2014 to 2016 were accessed from the cross-sectional database “Hypertension Levels and Epidemiological Characteristics of the Elderly and Centenarians in Hainan province of China”. This study included 690 centenarians with hypertension. Hypertension grading was the dependent variable, analyzed against independent variables including demographic information (sex, age, ethnicity, education level, marital status, cohabitation, and regional distribution), lifestyle factors (smoking, alcohol consumption, and physical activity), body mass index (BMI), and comorbid conditions (diabetes and hyperlipidemia). Logistic regression models, adjusted for these factors, were used to assess the determinants of hypertension grading among the participants. Results: Multivariate regression analysis, after adjusting for other variables, revealed significant associations between BMI, low-density lipoprotein (LDL) levels, and hypertension grades. Individuals with BMI below 18.5 kg/m2 had a 0.614-fold lower risk of developing grade III hypertension (odds ratio [OR]: 0.614, 95% confidence interval [CI]: 0.390–0.966, p = 0.0350) and a 0.586-fold lower risk for grade II hypertension (OR: 0.586, 95% CI: 0.402–0.852, p = 0.0052). Furthermore, individuals with elevated LDL levels had a 6.087-fold greater risk of progressing from grade I to grade III hypertension (OR: 6.087, 95% CI: 1.635–22.660, p = 0.0071) and a 4.356-fold greater risk of progressing from grade II to grade III hypertension (OR: 4.356, 95% CI: 1.052–18.033, p = 0.0423). Additionally, individuals of Li ethnicity had 1.823-fold greater risk of progressing from grade I to grade II hypertension compared to those of Han ethnicity (OR: 1.823, 95% CI: 1.033–3.218, p = 0.0383). Conclusions: A BMI below 18.5 kg/m2, elevated LDL, and ethnicity emerged the primary factors associated with hypertension grading in centenarians. To reduce the risk of hypertension, it is crucial for centenarians to maintain a healthy weight, normal LDL levels, and adopt dietary habits including a low-cholesterol and low-fat diet.
Bayesian Approach to Forecasting Aggregate Taxes of the Republic of Armenia
Authors:   Ministry of Finance of Republic of Armenia, Yerevan, Republic of Armenia, Petrosyan G.A. , Karapetyan N.N. ,   Ministry of Finance of Republic of Armenia, Yerevan, Republic of Armenia, Margaryan A.A. ,   Ministry of Finance of Republic of Armenia, Yerevan, Republic of Armenia, Sokolov A.N. ,   Financial Research Institute, Moscow, Russian Federation, Yakovleva I.I. ,   Financial Research Institute, Moscow, Russian Federation, Votinov A.I. ,   Financial Research Institute, Moscow, Russian Federation
Published: June 2024

This paper is devoted to the application of the Bayesian approach to the forecasting of aggregate taxes on the example of the Republic of Armenia. Typically, this approach is used in large-scale BVARs to forecast macroeconomic variables. The objective of this study is to estimate the efficiency of the Bayesian approach to constricting relatively low-scale fiscal VARs. Another objective is to build a specific BVAR model for forecasting tax revenues in the context of actual forecasting rounds. The study is based on seasonally adjusted quarterly aggregate tax data and the corresponding proxy bases. A hierarchical approach to the selection of BVAR’s priors is implemented. It assumes the random nature of variances in the prior values of the coefficients. The hierarchical approach is also characterized by a high level of variability of hyperparameters. To determine the optimal structure of the BVAR model in terms of out-of-sample prediction accuracy, a special algorithm was developed. This algorithm involves a specific procedure for the selection of priors and model parameters, which allows to significantly minimize the prediction error. The Geweke and Gelman-Rubin tests were used/considered to check the convergence of the parameters, and the acceptance rate of the Metropolis-Hastings algorithm was taken into account. It Additional priors, such as the sum-of-coefficients prior and the dummy-initialobservation prior (single-unit-root), are shown to improve the quality of out-of-sample forecasts. These priors allow for the possibility of the existence of a single root and cointegration between variables. The main finding of this study is that the proposed algorithm for selecting parameters in BVAR significantly improves out-of-sample performance compared to traditional frequency VAR.
The effects of isolated game elements on adherence rates in food-based response inhibition training
Authors: MacLellan Alexander , Pennington Charlotte Rebecca , Lawrence Natalia , Westwood Samuel James , Jones Andrew , Slegrova Anna , Sung Beatrice , Parker Louise , Relph Luke , Miranda Jessica Oliveira , Shakeel Maryam , Mouka Elizabeth , Lovejoy Charlotte , Chung Chaebin , Lash Sabela , Suhail Yusra , Nag Mehr , Button Katherine Susan
Published: June 2024

Introduction: Poor diet, and the consumption of foods high in fat, sugar and salt are common causes of numerous health conditions and premature mortality. Computerised food response inhibition training (food-RIT) is a type of intervention found to aid weight loss and reduce snacking of these foods with the inhibition of motor responses proposed to operate through the process of stimulus devaluation. However, these interventions are repetitive by nature and suffer from a lack of adherence, leading some to propose gamification as a solution to increase engagement. The effect of gamification is unclear, however, with a lack of research investigating the effects of single game elements in improving adherence to interventions. The current study therefore aims to investigate whether isolated common game elements (social or feedback) improve adherence, engagement and effectiveness of computerised food response inhibition training compared to standard non-gamified intervention. Methods: A sample of 252 participants (169 Female) were randomly assigned to either a standard non-gamified food response inhibition training, a training gamified with feedback elements, or a training gamified with social elements. Participants completed measures of snacking frequency and food evaluation before and after a 14-day training period, during which they were instructed to complete their assigned training. Training adherence and daily training motivation was recorded during this training period. Results: There were no significant effects of adding either feedback or social gamification elements improved training adherence, motivation, or effectiveness. Conclusions: This study finds no meaningful support for adding isolated game elements to food-RIT with a view to improving intervention adherence. These results raise questions about the magnitude of simple gamification effects, and future research may benefit from assessing the combined effects of multiple gamification elements in such cognitive interventions.
Me, my brain and I: a framework for neuroscience curriculum fostering research-practice partnership between scientists and educators
Authors: Korisky Adi , Davidesco Ido , Abu Ofek Ben , Levy Orel , Abrahami Klil , Gery Orli , Golumbic Elana Zion
Published: June 2024

Students' school requirements and learning activities engage many different cognitive processes, including as language processing, memory, learning, attention, reasoning, decision making, and social interaction. However, student rarely learn about these cognitive processes or the brain mechanisms underlying them, and therefore lack critical understanding about they themselves operate. Here, we describe a novel neuroscience curriculum, developed through a Research-Practice Partnership (RPP) between neuroscientists and educators, aimed at allowing students to learn about their own brain and cognitive abilities and engage in authentic neuroscientific inquiry. The curriculum is organized around three pillars: Learn Neuroscience – Experience Neuroscience – Contribute to Neuroscience. These are designed to optimize relevance, student engagement and interactive hands-on experience. In particular, by incorporating genuine neuroscientific research as part of the program, students are offered a front-row seat to the scientific process using cutting-edge neurotechnology and gain first-hand experience with the challenges and excitements of scientific inquiry.
The role of spatial location in irrelevant speech revisited: A registered replication of Jones and Macken (1995)
Authors: Kattner Florian , Hassanzadeh Mitra , Ellermeier Wolfgang
Published: June 2024

The goal of the present investigation was to perform a registered replication of Jones and Macken’s (1995b) study, which showed that the segregation of a sequence of sounds to distinct locations reduced the disruptive effect on serial recall. Thereby, it postulated an intriguing connection between auditory stream segregation and the cognitive mechanisms underlying the irrelevant speech effect. Specifically, it was found that a sequence of changing utterances was less disruptive in stereophonic presentation allowing each auditory object (letters) to be allocated to a unique location (right ear, left ear, center), compared to when the same sounds were played monophonically. Due to its importance for theoretical accounts of auditory distraction and because the results were somewhat equivocal, it is important to replicate this influential study with enhanced statistical power. The present replication (N=60) confirmed that the disruptive effect of a changing-state sequence ("V-J-X") as compared to a steady-state sequence ("J-J-J") - the changing-state effect - is reduced significantly with stereophonic presentation, suggesting that listeners perceptually grouped the presented sound into three separate steady-state streams, which produce much less interference with seriation compared to the monophonic presentation. However, in contrast to the original study, stereophonic steady-state sequences were found to be slightly more disruptive than monophonic sequences, suggesting that the change in location may also cause some interference on its own. Moreover, there was also a significant steady-state effect, with both steady-state conditions being more disruptive than silence. The results are discussed with regard to interference-by-process and attentional accounts of auditory distraction.
Latent trajectories of positive, negative symptoms and functioning in early intervention services for first-episode psychosis: A 2-year follow-up study
Authors: Percie du Sert Olivier , unrau joshua , Dama Manish , Palaniyappan Lena , Shah Jai , Joober Ridha , Raucher-Chéné Delphine , Malla Ashok K. , Lepage Martin
Published: June 2024

Background: From the first episode (FEP), the course of psychosis is marked by substantial heterogeneity of clinical and functional outcomes which poses significant challenges in providing prognostic guidance to patients and families. To better understand such heterogeneity within the context of early interventions servives (EIS), this study aimed to examine latent trajectories of positive, negative symptoms and functioning among FEP individuals undergoing EIS. Study design: The Prevention and Early Intervention Program for Psychoses (PEPP-Montreal) is a 2-year EIS for FEP that conducted longitudinal assessments of 689 individuals aged 14-35, including sociodemographics, cognition, psychopathology, and functioning. Latent growth mixture modelling was used to identify distinct patterns of clinical and functional trajectories. The inter-relationship between trajectories, and the association of trajectory membership with baseline characteristics and distal outcomes were investigated using the manual three-step approach.Study results: Two positive symptom trajectories (Stable-low -32%, Fluctuating -68%,), three negative symptom trajectories (Decreasing -41%, Fluctuating -15%, Stable-high -44%,) and two functioning trajectories (Increasing -57%, Stable-moderate -43%) were identified. Early treatment response, particularly on negative symptoms, consistently and strongly predicted better outcome trajectories (OR=[3.4-5.5]). Trajectories of higher symptom severity were associated with trajectory of worse functioning (RR=[1.5-2.2]), which exhibited lower rates of clinical and functional remission. Conclusion: These findings offer insights into clinically meaningful subgroups of individuals that could inform the prognosis of FEP and the development of individually tailored EIS. Individuals who do not show early improvement in negative symptoms may benefit from earlier psychosocial interventions specifically targeting actionable factors that contribute to secondary negative symptoms.
Filosofi Pendidikan Inklusi dalam Sistem Pendidikan Indonesia Menuju Merdeka Belajar
Authors: Yasjulia Rosi
Published: June 2024

Pendidikan Inklusi merupakan filosofi menghargai keberagaman. Artikel ini bertujuan untuk memahami konsep pendidikan inklusi, filosofi pendidikan inklusi, dan mengkaji implementasi pendidikan inklusi dalam sistem pendidikan di Indonesia sebagai perwujudan pemenuhan hak individu terhadap pendidikan. Artikel ini tersusun melalui studi literasi dengan mengumpulkan berbagai referensi hasil penelitian, artikel, dan pedoman pelaksanaan pendidikan inklusi. Filosofi pendidikan inklusi di Indonesia dipengaruhi oleh nilai-nilai keberagaman dan kesetaraan yang terdapat dalam Pancasila dan Undang-Undang Dasar 1945. Di Indonesia, perjalanan menuju pendidikan inklusif telah mengalami perkembangan yang signifikan dalam beberapa tahun terakhir. Pemerintah Indonesia telah melakukan langkah-langkah konkret untuk memperluas akses pendidikan bagi anak-anak dengan kebutuhan khusus. Pendidikan inklusif di Indonesia bukan hanya tentang memasukkan anak-anak dengan kebutuhan khusus ke dalam kelas reguler, tetapi juga dengan menciptakan lingkungan belajar yang ramah dan mendukung bagi semua siswa. Hal ini sejalan dengan semangat Merdeka Belajar yang menekankan pada kebebasan, keberagaman, dan kesetaraan dalam proses pembelajaran.
Biostatistical Analysis on Recent Issues : A Sampling study
Authors: Chaudhary Satya Narayan
Published: June 2024

This paper aims at examining the statistical methodology used in the research articles published in the journals of high repute. Conducting the correct statistical analysis is of paramount importance in every research, and hence, statistical methodology has often been checked predominantly in journals. In this paper, the original research articles published in the top 10 leading medical journals published in India, and indexed by PubMed in 2003 and a decade later in 2013 have been reviewed. The present article examined—study design types, frequencies of statistical methods, errors/defects in study design and statistical analyses, and also the implementation of CONSORT checklist in RCT’s (randomized clinical trials). Chi-square and Fisher’s exact tests, (wherever appropriate) were used to compare any proportional differences in use of statistical methods and various errors/defects during the 10 years in the study period. All the tests used in this article were conducted at 5% level of significance and were 2-tailed. Chi-square tests were conducted at one degree of freedom. Using arbitrary p thresholds (like p<0.01) instead of reporting exact p-values, reporting p value without test statistics, insufficient (or inappropriate) description of methods and p values without confidence intervals were most common of the errors present. In conclusion, this study indicates that Indian medical research seems to have made some progress regarding study design defects, but there remains ample room for improvement regarding statistical analyses. Most published studies continue to use a retrospective clinical design, with randomized clinical trials being quite rare. Those RCTs that are published often have serious methodological problems, including absence of sample size estimation and power calculations, as well as failure in (or in the reporting of) randomization.