bluuebunny/crossref_metadata_2025 huggingface dataset:
Dedifferentiated Liposarcoma in the Spermatic Cord Finally Diagnosed at 7th Resection of Recurrence: A Case Report and Bibliographic Consideration
Authors: Morozumi Kento , Kawasaki Yoshihide , Kaiho Yasuhiro , Kawamorita Naoki , Fujishima Fumiyoshi , Watanabe Mika , Arai Yoichi
Published: August 2017

Liposarcoma in the spermatic cord is infrequent, and accurate diagnosis of histopathological subtype is often difficult in spite of the importance of differential diagnosis for adequate treatment. A 54-year-old man underwent left-sided high orchiectomy with inguinal lymphadenectomy for a spermatic cord tumor in July 2006. The initial histopathological report diagnosed leiomyosarcoma in the spermatic cord. He then underwent surgeries for repeated recurrences a further 6 times between July 2008 and May 2014. Pathological finding at the 7th resection of the recurrent tumor was osteosarcoma, which was uncommon in the spermatic cord. With a thorough overview of all specimens, the histopathological diagnosis was finally confirmed as dedifferentiated liposarcoma because of a biphasic pattern in the specimen of high orchiectomy at the first resection. A biphasic pattern represents high-grade sarcoma like osteosarcoma and well-differentiated liposarcoma, and is characteristic of dedifferentiated liposarcoma. Although the dedifferentiated type is one of poor prognosis, the diagnosing of liposarcoma histopathologically was found to be difficult throughout this case. In this report we discuss the accurate histopathological diagnosis of liposarcoma in the spermatic cord in order to prevent repeated recurrences based on a review of the literature, as well as the difficulty in recognizing dedifferentiated liposarcoma macroscopically and morphologically. Our experience suggests that, after much difficulty, accurate histopathological diagnosis of liposarcoma in the spermatic cord is still clinically challenging.
Triggering of Eryptosis, the Suicidal Erythrocyte Death by Mammalian Target of Rapamycin (mTOR) inhibitor Temsirolimus
Authors: Bhuyan Abdulla Al Mamun , Cao Hang , Lang Florian
Published: August 2017

Background/Aims: The mammalian target of rapamycin (mTOR) inhibitor temsirolimus is utilized for the treatment of malignancy. Temsirolimus is at least in part effective by triggering suicidal tumor cell death. The most common side effect of temsirolimus treatment is anemia. At least in theory, the anemia following temsirolimus treatment could result from stimulation of eryptosis, the suicidal erythrocyte death. Hallmarks of eryptosis include cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signaling involved in the orchestration of eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress, ceramide, as well as activation of staurosporine and chelerythrine sensitive protein kinase C, SB203580 sensitive p38 kinase, D4476 sensitive casein kinase 1, and zVAD sensitive caspases. The purpose of the present study was to test whether temsirolimus influences eryptosis and, if so, to shed light on the signaling involved. Methods: Flow cytometry was employed to estimate cell volume from forward scatter, phosphatidylserine exposure at the cell surface from annexin-V-binding, [Ca2+]i from Fluo3-fluorescence, reactive oxygen species (ROS) abundance from DCFDA dependent fluorescence, and ceramide abundance utilizing specific antibodies. Hemolysis was determined from hemoglobin concentration in the supernatant. Results: A 48 hours exposure of human erythrocytes to temsirolimus (5 – 20 µg/ml) significantly decreased forward scatter and significantly increased the percentage of annexin-V-binding cells. Temsirolimus significantly increased Fluo3-fluorescence, DCFDA fluorescence and ceramide abundance at the erythrocyte surface. The effect of temsirolimus on annexin-V-binding was significantly blunted but not abolished by removal of extracellular Ca2+ and by addition of staurosporine (1 µM) or chelerythrine (10 µM) but not significantly modified by addition of SB203580 (2 µM), D4476 (10 µM), or zVAD (10 µM). Chelerythrine (10 µM) further significantly blunted the effect of temsirolimus on DCFDA fluorescence but not ceramide formation. Removal of extracellular Ca2+ had no effect on temsirolimus induced ROS formation or ceramide abundance. Conclusions: Temsirolimus triggers eryptosis with cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane, an effect at least in part due to Ca2+ entry, oxidative stress, ceramide and activation of staurosporine/Chelerythrine sensitive kinase(s).
Synchronous Endometrial and Ovarian Carcinoma: A Case Series
Authors: Makris Georgios-Marios , Manousopoulou Georgia , Battista Marco-Johannes , Salloum Ioannis , Chrelias Georgios , Chrelias Charalampos
Published: August 2017

Synchronous ovarian and endometrial cancer (SEOC) is a rare instance but it accounts for 50–70% of all synchronous female genital tract tumors. We report three cases of women who were diagnosed with SEOC and underwent surgical staging. All cases were of the endometrioid subtype, grade 1, both in the ovarian and endometrial component. Two of them were stage Ia/Ia, and the third was stage Ib/Ib. More than 2 years after the diagnosis, all patients were alive and recurrence-free. The present report critically discusses the main characteristics, risk factors, and management of patients with SEOCs.
Older Age at Multiple Sclerosis Onset Is an Independent Factor of Poor Prognosis: A Population-Based Cohort Study
Authors: Guillemin Francis , Baumann Cédric , Epstein Jonathan , Kerschen Philippe , Garot Teresa , Mathey Guillaume , Debouverie Marc ,   on behalf of the LORSEP Group
Published: August 2017

Background: Late-onset multiple sclerosis (LOMS) frequently features a primary progressive (PP) course, strongly predicting severe disability. In this population-based cohort, we estimated the prognostic role of age at multiple sclerosis (MS) onset, independent of PP course, on disability progression. Methods: The association of age at disease onset (adult, <50 years [AOMS], vs. late, ≥50 years [LOMS]) and time to Expanded Disability Status Scale (EDSS) score 4 and 6 was estimated by Cox regression modelling. Results: Among 3,597 patients, 245 had LOMS. Relapsing-remitting (RR) disease was less frequent with LOMS than AOMS (51.8 vs. 90.8%, p < 0.0001). PP course, LOMS and male gender predicted short time to EDSS 4 and 6. Worse outcome with LOMS (time to EDSS 4 and 6, HR 2.0 [95% CI 1.7-2.4] and 2.3 [1.9-2.9]) was independent of PP course or male gender. LOMS had greater impact on RR than PP disease (time to EDSS 4 and 6, HR 3.1 [2.3-4.0] and 4.0 [2.9-5.6]). Only LOMS predicted time from EDSS 4 to 6 (p < 0.0001). Conclusions: Late onset MS was strongly associated with poor prognosis, independent of initial disease course, in predicting the disability progression along time.
Macrophage Overexpressing NGAL Ameliorated Kidney Fibrosis in the UUO Mice Model
Authors: Guiteras Roser , Sola Anna , Flaquer Maria , Hotter Georgina , Torras Joan , Grinyó Josep Maria , Cruzado Josep Maria
Published: August 2017

Background/Aims: Alternatively activated macrophages (AAM) have regenerative and anti-inflammatory characteristics. Here, we sought to evaluate whether AAM cell therapy reduces renal inflammation and fibrosis in the unilateral ureteral obstruction (UUO) mice model. Methods: We stabilized macrophages by adenoviral vector NGAL (Neutrophil gelatinase-associated lipocalin-2) and infused them into UUO mice. To ascertain whether macrophages were capable of reaching the obstructed kidney, macrophages were stained and detected by in vivo cell tracking. Results: We demonstrated that some infused macrophages reached the obstructed kidney and that infusion of macrophages overexpressing NGAL was associated with reduced kidney interstitial fibrosis and inflammation. This therapeutic effect was mainly associated with the phenotype and function preservation of the transferred macrophages isolated from the obstructed kidney Conclusions: Macrophage plasticity is a major hurdle for achieving macrophage therapy success in chronic nephropathies and could be overcome by transferring lipocalin-2.
CKM
Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia
Authors: Siddiqui Moneeza Kalhan , Veluchamy Abirami , Maroteau Cyrielle , Tavendale Roger , Carr Fiona , Pearson Ewan , Colhoun Helen , Morris Andrew D. , George Jacob , Doney Alexander , Pirmohamed Munir , Alfirevic Ana , Wadelius Mia , Maitland van der Zee Anke H. , Ridker Paul M. , Chasman Daniel I. , Palmer Colin N.A.
Published: August 2017

Background—

To test the association of a recently reported variant in the creatine kinase (CK) muscle gene,
CKM
Glu83Gly (rs11559024) with constitutive creatine phosphokinase (CK) levels, CK variation, and inducibility. Given the diagnostic importance of CK in determining muscle damage, we tested the association of the variant with myalgia.

Methods and Results—

Meta-analysis between longitudinal cohort GoDARTS (Genetics of Diabetes Audit and Research, Tayside Scotland), minor allele frequency (=0.02), and randomized clinical trial (JUPITER [Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin], minor allele frequency=0.018) was used to replicate the association with baseline CK measures. GoDARTS was used to study the relationship with CK variability. Myalgia was studied in JUPITER trial participants. Baseline and SDs of CK were on average 18% (
P
value=6×10
−
63
) and 24% (
P
value=2×10
−5
) lower for carriers of the variant, respectively. The variant was not associated with myalgia (odds ratio, 0.84; 95% confidence interval, 0.52–1.38).

Conclusions—

This study highlights that a genetic factor known to be associated with constitutive CK levels is also associated with CK variability and inducibility. This is discussed in the context of evidence to suggest that the variant has an impact on inducibility of CK by trauma through a previously reported case of a homozygous carrier. However, the lack of association between the variant and myalgia suggests that it cannot reliably be used as a biomarker for muscle symptoms.
The Death of Honi the Circle Maker
Authors: Ron Zvi
Published: August 2017

Ancient literature preserves two accounts of the death of Honi the Circle Maker. One is in Josephus, where Honi is murdered by Jews after failing to participate in the Hasmonean civil war; the other is found in B. Ta. 23a, where Honi prays for death when nobody recognizes him after he awakes from sleeping for seventy years. While these two accounts seem to have no relation to each other, upon comparing the Bavli story to other tales of saintly long sleepers it appears that the Bavli story is a negative twist on the classic plot. The Bavli story is now understood as an aggadic version of the Josephus story, in the same category as the Bar Kamtza story and other similar explanatory narratives meant to highlight the reasons for tragedies in Jewish history.
Southeastern Australian Heat Waves from a Trajectory Viewpoint
Authors: Quinting Julian F. , Reeder Michael J.
Published: August 2017

Although heat waves account for more premature deaths in the Australian region than any other natural disaster, an understanding of their dynamics is still incomplete. The present study identifies the dynamical mechanisms responsible for heat waves in southeastern Australia using 10-day backward trajectories computed from the ERA-Interim reanalyses. Prior to the formation of a heat wave, trajectories located over the south Indian Ocean and over Australia in the lower and midtroposphere ascend diabatically ahead of an upper-level trough and over a baroclinic zone to the south of the continent. These trajectories account for 44% of all trajectories forming the anticyclonic upper-level potential vorticity anomalies that characterize heat waves in the region. At the same time, trajectories located over the south Indian Ocean in the lower part of the troposphere descend and aggregate over the Tasman Sea. This descent is accompanied by a strong adiabatic warming. A key finding is that the temperatures are raised further through diabatic heating in the boundary layer over eastern Australia but not over the inner Australian continent. From eastern Australia, the air parcels are advected southward as they become incorporated into the near-surface anticyclone that defines the heat wave. In contrast to past studies, the importance of cloud-diabatic processes in the evolution of the midlatitude large-scale flow and the role of adiabatic compression in elevating the near-surface temperatures is emphasized. Likewise, the role of the local surface sensible heat fluxes is deemphasized.
Perception of isolated chords: Examining frequency of occurrence, instrumental timbre, acoustic descriptors and musical training
Authors: Arthurs Yuko , Beeston Amy V. , Timmers Renee
Published: August 2017

This study investigated the perception of isolated chords using a combination of experimental manipulation and exploratory analysis. Twelve types of chord (five triads and seven tetrads) were presented in two instrumental timbres (piano and organ) to listeners who rated the chords for consonance, pleasantness, stability and relaxation. Listener ratings varied by chord, by timbre, and according to musical expertise, and revealed that musicians distinguished consonance from the other variables in a way that other listeners did not. To further explain the data, a principal component analysis and linear regression examined three potential predictors of the listener ratings. First, each chord’s frequency of occurrence was obtained by counting its appearances in selected works of music. Second, listeners rated their familiarity with the instrumental timbre in which the chord was played. Third, chords were described using a set of acoustic features derived using the Timbre Toolbox and MIR Toolbox. Results of the study indicated that listeners’ ratings of both consonance and stability were influenced by the degree of musical training and knowledge of tonal hierarchy. Listeners’ ratings of pleasantness and relaxation, on the other hand, depended more on the instrumental timbre and other acoustic descriptions of the chord.
The Commercial Street Photographer: The Right to the Street and the Droit à l’Image in Post-1945 France
Authors: Clark Catherine E.
Published: August 2017

This article examines the history of the commercial street photographer, or photofilmeur, in France from 1945 to 1955. Although itinerant photographers had long operated, they organized as a new profession after the Second World War in response to hostile reactions from other ‘sedentary’ photographers, conservative officials, lawmakers, and the police. Tracing the fight to regulate and even ban photofilmeurs in state and police archives, courtroom accounts, and union publications, this article reveals a struggle over the who, what, and where of photography: Who has the right to photograph whom? Can you take pictures of people without their consent? What is professional photography? Answers to these questions recast the history of street photography not as an aesthetic category, as most scholarship treats it, but in terms of the medium’s engagement with the law and issues of consent, intent, copyright, privacy, and dissemination that are at the heart of 20th and 21st-century photographic history.
Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions
Authors: Morita Ken , Maeda Shintaro , Suzuki Kensho , Kiyose Hiroki , Taniguchi Junichi , Liu Pu Paul , Sugiyama Hiroshi , Adachi Souichi , Kamikubo Yasuhiko
Published: August 2017

Key Points

Moderate attenuation of RUNX1 expression upregulates total RUNX expressions and enhances leukemogenesis through RUNX-GSTA2-ROS axis. Inhibiting GSTA2 function in vivo prolongs the overall survival of AML mice with intermediate RUNX1 expressions.
A review of transanal irrigation in adults
Authors: Wilson Mary
Published: August 2017

This article discusses transanal irrigation: what it is, the clinical conditions that might be helped by it and less invasive options that should be considered before starting irrigation. It looks at the delivery of this procedure, describes the different options available and compares and contrasts devices manufactured by five different companies. Contraindications are listed and side-effects discussed. Problems and possible solutions are considered. Transanal irrigation education for nurses and teaching patients is reviewed. Follow-up is discussed, including the reasons why some patients abandon irrigation. Quality of life can be improved for those who become successful users of transanal irrigation. When patients do continue to irrigate, even when this is not problem free, it can help them regain control over their bowel dysfunction by allowing them to evacuate their bowels at a time and a place that is convenient.
Cortrak tube placement part 2: guidance to avoid misplacement is inadequate
Authors: Taylor Stephen J , Clemente Rowan , Allan Kaylee , Brazier Sophie
Published: August 2017

Electromagnetic (EM)-guided tube placement has been successfully used to pre-empt lung misplacement, but undetected misplacements continue to occur. The authors conducted an audit to investigate whether official Cortrak or local guidance enabled differentiation of gastrointestinal (GI) from lung traces. X-ray, pH or an EM trace beyond the gastric body were used to independently confirm gastric position. The authors undertook 596 nasointestinal (NI) tube placements, of which 361 were primary GI placements and 41 lung misplacements. Official guidance that in GI traces a midline deviation is absent cannot differentiate GI from lung traces because deviation is common in both. However, when comparing a trace in the same patient, midline deviation during lung misplacement always occurred >18 cm above the horizontal line compared with only 33% of the subsequent GI deviation (p<0.0001). Official guidance could lead to aborted GI placements or undetected lung placements. EM-guided placement must have an expert-led understanding of the 3D trace pattern, artefact correction and appraised practical experience differentiating GI from lung placement. The authors invite Halyard Health to update guidance in view of these findings.
Security in the Anthropocene
Authors: Harrington Cameron , Shearing Clifford
Published: August 2017

The belief that »Nature« exists as a blank, stable stage upon which humans act out tragic performances of international relations is no longer tenable. In a world defined by human action, we must reorient our understanding of ourselves, of our environment, and our security. This book considers how decentred and reflexive approaches to security are required to cope with the Anthropocene - the Human Age. Drawing from various disciplines, this bold reinterpretation explores the possibilities for understanding and preparing a future that will look vastly different than the past. The book asks to dig deeper into what it means to be human and secure in an age of ecological exception. "In a growing field of interdisciplinary work on the Anthropocene, ›Security in the Anthropocene‹ sets itself apart. It blends ideas from criminology, international security studies and the environmental humanities to provide unique interdisciplinary insight into the challenges of living on an increasingly turbulent earth." - Audra Mitchell, Balsillie School of International Affairs/Wilfrid Laurier University "This essential, groundbreaking book offers a new conceptual framework that recalibrates what security means in the Anthropocene. Not content on simply highlighting the state of crisis fostered by existential risks in this new era, Cameron Harrington and Clifford Shearing invite us to imagine a more positive and caring form of security." - Benoit Dupont, University of Montreal "Harrington and Shearing's fine book explores evocatively how humans might cope with a world that is fundamentally changed through a critical appraisal of how new impacts on the Earth system shift the conditions of security. This is a tour de force of how our concepts of security create the world that afflicts us. The authors argue, convincingly, that there can be no security in the Anthropocene without an expanded vision of care." - John Braithwaite, Australian National University
Solutions and Stability of Generalized Kannappan’s and Van Vleck’s Functional Equations
Authors: Elqorachi Elhoucien , Redouani Ahmed
Published: August 2017

We study the solutions of the integral Kannappan’s and Van Vleck’s functional equations ∫Sf(xyt)dµ(t)+∫Sf(xσ(y)t)dµ(t)= 2f(x)f(y), x,y ∈ S; ∫Sf(xσ(y)t)dµ(t)-∫Sf(xyt)dµ(t)= 2f(x)f(y), x,y ∈ S; where S is a semigroup, σ is an involutive automorphism of S and µ is a linear combination of Dirac measures ( ᵟ zi)I ∈ I, such that for all i ∈ I, ziis in the center of S. We show that the solutions of these equations are closely related to the solutions of the d’Alembert’s classic functional equation with an involutive automorphism. Furthermore, we obtain the superstability theorems for these functional equations in the general case, where σ is an involutive morphism.
An Extension of a Ger’s Result
Authors: Marinescu Dan Ştefan , Monea Mihai
Published: August 2017

The aim of this paper is to extend a result presented by Roman Ger during the 15th International Conference on Functional Equations and Inequalities. First, we present some necessary and sufficient conditions for a continuous function to be convex. We will use these to extend Ger’s result. Finally, we make some connections with other mathematical notions, as g-convex dominated function or Bregman distance.
Some fixed point results for rational type and subrational type contractive mappings
Authors: Huang Huaping , Ansari Arslan Hojat , Dolićanin-Đekić Diana , Radenović Stojan
Published: August 2017

In this paper, we introduce the concepts of rational type and subrational type contractive mappings. We expand and improve some fixed point theorems obtained by Alsulamiet al.(Fixed Point Theory Appl., 2015, 2015: 97). Moreover, we give an example to support our results.
ps-ro fuzzy strongly α-irresolute function
Authors: Chettri Pankaj , Chettri Anamika
Published: August 2017

The prime objective of this paper is to introduce and characterize a new type of function in a fuzzy topological spaces called ps-ro fuzzy strongly α-irresolute function. The interrelations of this function with the parallel existing allied concepts are established. The independence of ps-ro fuzzy strongly α-irresolute and well known concept of fuzzy strongly α-irresolute function motivate authors to explore it. Also, this function is found to be stronger than ps-ro fuzzy continuity, ps-ro fuzzy semicontinuity, ps-ro fuzzy precontinuity and ps-ro fuzzy α-continuity. Further, several characterizations of these functions along with different conditions for their existence are obtained.
Photonic-Assisted mm-Wave and THz Wireless Transmission towards 100 Gbit/s Data Rate
Authors: Freire Hermelo Maria , Chuenchom Rattana , Rymanov Vitaly , Kaiser Thomas , Sheikh Fawad , Czylwik Andreas , Stöhr Andreas
Published: August 2017

This paper presents photonic-assisted 60 GHz mm-wave and 325 GHz system approaches that enable the transmission of spectral-efficient and high data rate signals over fiber and over air. First, we focus on generic channel characteristics within the mm-wave 60 GHz band and at the terahertz (THz) band around 325 GHz. Next, for generating the high data rate baseband signals, we present a technical solution for constructing an extreme bandwidth arbitrary waveform generator (AWG). We then report the development of a novel coherent photonic mixer (CPX) module for direct optic-to-RF conversion of extreme wideband optical signals, with a>5 dB higher conversion gain compared to conventional photodiodes. Finally, we experimentally demonstrate record spectral efficient wireless transmission for both bands. The achieved spectral efficiencies reach 10 bit/s/Hz for the 60 GHz band and 6 bit/s/Hz for the 325 GHz band. The maximum data rate transmitted at THz frequencies in the 325 GHz band is 59 Gbit/s using a 64-QAM-OFDM modulation format and a 10 GHz wide data signal.
ClO2-oxidation-based demulsification of oil-water transition layer in oilfields: An experimental study
Authors: Yuan Dandan , Tian Lei , Shen Xiaoyan , Sui Xin , Wang Baohui
Published: August 2017

Separation of oil and water is well known as a key process in the oil industry. For the purpose of improving the efficiency of the oil-water separation, a novel ClO
Gymnosporangium Species – An Important Issue of Plant Protection
Authors: Lāce Baiba
Published: August 2017

Rusts (Fungi, Basidiomycota, Pucciniomycotina, Pucciniomycetes, Pucciniales) are one of the most important causal agents of diseases and they are infecting many plants including cereals and field crops, vegetables, trees and many ornamentals. They have been studied for a long time and have economic importance among the plant diseases caused by agents of different species of fungi. In Europe, thirteen rust genera have been reported, of which the genus Gymnosporangium is the second largest after genus Phragmidium. The most significant fruit tree rust pathogen is the genus Gymnosporangium. The literature review shows quite limited scientific information about this genus and its species. Studies have mainly focused on some stages of the pathogen development cycle, which are significant for the spread of diseases - uredo and teleito stages. Special attention of the review was paid to European pear rust (caused by G. sabinae (Dicks.) G. Winter), the distribution of which has increased during the last ten years, especially in organic pear orchards. Currently there is a limited number of scientific publications about European pear rust, and they are mainly based only on observations in vitro without trials in the field, despite the fact that it has become one of the most devastating diseases. Therefore, the presented review analyses the rust exploration history, diversity and distribution of species, life cycle, development biology and plant protection issues.
A new outlook on the evaluation of health state and physical capacity of skiers with disabilities as exemplified by a female Paralympic Champion
Authors: Gawroński Wojciech
Published: August 2017

Introduction: Initially, sport for the disabled (including skiing) was only considered to be a follow-up to rehabilitation. Modifications concerning the rules and classifications of athletes (reducing the number of classes) led to increased competition and to the fact that winning started to be determined more by physical performance features than by a type of dysfunction. This required more regular training and greater training loads as well as observing health state and training effectiveness more carefully. The aim of the work is to present the methodology of assessing health state of the athletes and the level of their physical capacity and to discuss the results of the research conducted on a female skier during the period of her greatest achievements. Materials and methods: The research group consisted of cross-country skiers with motor disabilities who were preparing for Paralympic Games in the years 2002-2010. A regular complex model of assessing health was implemented. It consisted of medical examinations and a physical capacity test (to failure) during which selected physiological and metabolic indices as well as the amount of work and mean power were marked. Results: Health assessment consisted of the report confirming that the athlete is capable of taking part in training sessions and competitions. The results of a physical capacity test, i.e. duration of work, peak power and power at the anaerobic threshold as well as heart reactions show the moment when the subject demonstrated the highest level of physical capacity in the course of the observation. Conclusions: A regular observation makes it possible to prevent negative health consequences of increased training loads and to monitor the reactions of the subjects’ bodies to the tasks in particular periods of the preparation cycle. Sports achievements of the female athlete confirm the effectiveness of the training and observation, while her features may serve as an example of morpho-functional posture which enabled her to compete for the title of the Paralympic Champion in cross-country skiing.
Tadeusz Różewicz and Tadeusz Borowski: The Origin of a Parallel
Authors: Pietrych Piotr
Published: August 2017

It is an entrenched habit among the critics to connect the early poetry of Tadeusz Różewicz and Tadeusz Borowski’s concentration camp stories. However, this stereotype can be backed by no good proof either in the poems Różewicz wrote in the first years after the war or in their reception. The parallel Różewicz-Borowski was put out into the world by Jan Błoński in his Szkic portretu poety współczesnego [A portrait sketch of a contemporary poet] (1956); at that time the parallel became a handy tool in the battle with Socialist Realist critics and their evaluations of Różewicz’s poetry. The matching of the two authors was made all the more plausible by Różewicz’s comeback during the Polish Thaw. It was manifested not only in a spate of new poems but also in his decisions about the choice of poems representing the postwar phase for publications like Poezje zebrane [Collected Poems] (1957). In essence, the links between Różewicz and Borowski are intertextual. Różewicz must have been familiar with Borowski’s Auschwitz stories, which came as a shock to their first readers, and he would most certainly have read Rudolf Reder’s account of the extermination camp at Bełżec camp. Those two books helped to shape Różewicz’s experience of war that can found in his work.
Diagnosis of interspecific hybrids between Acacia mangium and A. auriculiformis using single nucleotide polymorphism (SNP) markers
Authors: Yuskianti Vivi , Huang Fa Xin , Zhang Bian Xiang , Shiraishi Susumu
Published: August 2017

This paper describes a diagnostic system to verify interspecific hybrids between Acacia mangium and A. auriculiformis using single nucleotide polymorphism (SNP) markers. Forty-eight DNA fragments were selected based on random amplified polymorphic DNAs (RAPD) amplified across 48 individuals from each parental species, and were transformed into 44 sequence-characterized amplified region (SCAR) markers. Five SNP markers that generated species-specific alleles for each species were selected from the 28 sequenced SCARs. A multiplex single nucleotide primer extension (SNuPE) analyses of the five SNPs using 40 A. mangium, 40 A. auriculiformis and 16 Acacia hybrids showed high discrimination power. This diagnostic system, with high discriminatory ability, provides a highly reliable and fast method for identifying interspecific hybrids of A. mangium and A. auriculiformis.
Genetic diversity of Anadenanthera colubrina Vell. (Brenan) var cebil, a tree species from the South American subtropical forest as revealed by cpSSR markers
Authors: Barrandeguy M. E. , García M.V. , Argüelles C. F. , Cervigni G. D. L.
Published: August 2017

Anadenanthera colubrina var cebil is a tree species native to the Upper Parana Atlantic Forest where human activities have severely impacted causing deep fragmentation. Microsatellites are not available in this species. Therefore, the first objective of this study was to generate chloroplast simple sequence repeats (cpSSR) by cross-species transfer. Understanding the evolutionary dynamics of subdivided populations is an important matter. In this way, a first approach to the characterization of the haplotypic diversity within and between populations as well as the genetic structure of native Argentinean populations were the main goals of this study.

Twenty four individuals from two populations of the Misiones province were studied and four cpSSR loci were tested. Two of them exhibited polymorphic patterns leading to the identification of 11 cpDNA haplotypes with high mean genetic diversity (GD=0.73). The minimum spanning network defined three clear groups which can be assigned to at least three subpopulations. AMOVA indicated that the total variance showed the highest percentage of variation (48%) within subpopulations with a fixation index (FST) statistically significant (FST=0.520; p<0.05). Brown’s two loci component analysis indicated that substructure population is present. Jost’s differentiation global index (Dest) was 0.049 while Dest pairwise comparison reflected a certain level of genetic structure.

The high diversity level detected in the adult trees of A. colubrina var cebil from the populations under study could be due to recent human influence. In this way, the reduction in population size caused a reduction in the number of trees leading to surviving trees showing the historical diversity of the populations analyzed.
Update of Antiplatelet Therapy in Patients Without Known Cardiovascular Disease
Authors: Tomasevic Miloje , Aleksandric Srdjan , Stojkovic Sinisa
Published: August 2017

Platelet activation and aggregation play a critical role in thrombosis, a fundamental pathophysiologic event responsible for the acute clinical manifestations of atherothrombotic events such as acute coronary syndrome, myocardial infarction, ischemic stroke/transient ischemic attack and peripheral artery disease. Dual antiplatelet therapy (low-dose aspirin plus ADP-P2Y12 receptor blockers) has become the cornerstone of therapy for the management of acute and chronic coronary artery disease and the prevention of ischemic complications associated with percutaneous coronary intervention. However, dual antiplatelet therapy in primary prevention of cardiovascular disease in patients without known cardiovascular disease did not significantly reduce the risk of cardiovascular events, such as myocardial infarction, stroke or death, but significantly increased the rate of bleeding. Furthermore, despite multiple randomized controlled trials evaluating the efficacy and safety of aspirin use in patients without known cardiovascular disease, its role in primary prevention is still unclear, especially in patients with a higher risk of cardiovascular disease (non-diabetic individuals with >2 risk factors for coronary artery disease, elderly >60 years with additional risk factors, and patients with diabetes). Currently, there are four ongoing randomized controlled trials aiming to fill the missing gap in the efficacy and safety of aspirin therapy for primary prevention in these patients. The current European and United States Guidelines agree that primary prevention of cardiovascular disease is essential, but there are some substantial differences in risk estimation and treatment strategies among patients without known cardiovascular disease. This short review is focused on these differences and practical treatment approach to these patients based on present European and United States recommendations.
The Effects of Chronic Administration of Cisplatin on Oxidative Stress in the Isolated Rat Heart
Authors: Smigic Jelena , Stojic Isidora , Zivkovic Vladimir , Srejovic Ivan , Nikolic Tamara , Jeremic Jovana , Sabo Tibor , Jakovljevic Vladimir
Published: August 2017

Taken into consideration that molecular and cellular mechanisms involved in cardiotoxicity are still not clear the aim of this study was to compare the production of oxidative stress parameters in the isolated rat heart between animals chronically treated with cisplatin and saline. Th e hearts of male Wistar albino rats (n = 24, 12 per group, age 8 weeks, body mass 250±50 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40-120 cmH2O). We followed the production of superoxide anion radicals, hydrogen peroxide, and nitrites and also index of lipid peroxidation during the changes of coronary perfusion pressure (CPP) (from 40 to 120 cm H2O) in coronary venous effluent. Modifications CPP were performed in order to determined if oxidative stress is involved in coronary endothelium response in conditions of hypoxia (lower than 60 cm H2O) and hyperoxia (higher than 80 cm H2O). Based on the results of this research we can conclude that with enhancement of CPP the values of oxidative stress statistically increased. However, this increment is more prominent in control group as a result of preserved endothelium and its more powerful response to hyperoxia. On the other hand, damaged endothelium of cisplatin-treated animals had weaker response to hyperoxia, and also lower antioxidant capacity.
The future: diagnostic and imaging advances in MEN1 therapeutic approaches and management strategies
Authors: Manoharan Jerena , Albers Max B , Bartsch Detlef K
Published: August 2017

Prospective randomized data are lacking, but current clinical expert guidelines recommend annual screening examinations, including laboratory assessments and various imaging modalities (e.g. CT, MRI, scintigraphy and EUS) for patients with multiple endocrine neoplasia type 1 (MEN1). Routine screening is proposed to detect and localize neuroendocrine manifestations as early as possible. The goal is timely intervention to improve quality of life and to increase life expectancy by preventing the development of life-threatening hormonal syndromes and/or metastatic disease. In recent years, some studies compared different and new imaging methods regarding their sensitivity and utility in MEN1 patients. This present article reviews the proposed diagnostic tools for MEN1 screening as well as potential future perspectives.
A note on the existence and construction of Dulac functions
Authors: Osuna Osvaldo , Rodríguez-Ceballos Joel , Vargas-De-León Cruz , Villaseñor-Aguilar Gabriel
Published: August 2017

This paper is concerned with a predator–prey model with hyperbolic mortality and prey harvesting. The parameter regions for the stability and instability of the unique positive constant solution of ODE and PDE are derived, respectively. Especially, the global asymptotical stability of positive constant equilibrium of the diffusive model is obtained by iterative technique. The stability and direction of periodic solutions of ODE and PDE are investigated by center manifold theorem and normal form theory, respectively. Numerical simulations are carried out to depict our theoretical analysis.
Ruoxia Li, Jinde Cao, Ahmad Alsaedi, Fuad Alsaadi Stability analysis of fractional-order delayed neural networks
Authors: Li Ruoxia , Cao Jinde , Alsaedi Ahmad , Alsaadi Fuad
Published: August 2017

At the beginning, a class of fractional-order delayed neural networks were employed. It is known that the active functions in a target model may be Lipschitz continuous, while some others may also possessing inverse Lipschitz properties. Based upon the topological degree theory, nonsmooth analysis, as well as nonlinear measure method, several novel sufficient conditions are established towards the existence as well as uniqueness of the equilibrium point, which are voiced in terms of linear matrix inequalities (LMIs). Furthermore, the stability analysis is also attached. One numerical example and its simulations are presented to illustrate the theoretical findings.
Alcaloides aporfínicos con actividad antituberculosa aislados de Ocotea discolor Kunth (Lauraceae)
Authors: Avila Murillo Monica Constanza , Albarracin Melo Lady Tatiana , Cuca Suárez Luis Enrique , Patiño Ladino Oscar Javier , Guzman Vasquez Juan David , Mchugh Thimothy , Begum Neelu
Published: August 2017

La tuberculosis causa miles de muertes a nivel mundial y que, actualmente, los fármacos usados no son suficientes y en ocasiones son obsoletos para su tratamiento, se hace necesaria la búsqueda de nuevos compuestos que ayuden a combatirla. Por tanto, se evaluó la actividad antituberculosis de los alcaloides ocoxilonina (1), ocoteina (2), dicentrina (3) y 1,2-metilendioxi-3, 10,11-trimetoxiaporfina (4), aislados de la madera de Ocotea discolor. Las estructuras fueron identificadas por medio del análisis de los datos espectroscópicos de resonancia magnética nuclear (NMR 1D – 1H, 13C, 2D – COSY, HSQC y HMBC), espectros de masas y comparación con datos de la literatura. Todos los compuestos aislados demostraron actividad antituberculosa, con un rango de variación en la concentración mínima inhibitoria entre 140 y 310 μM, siendo la ocoteina (2) la más activo contra la cepa virulenta de Mycobacterium tuberculosis H37Rv.
Figurines de moda y formación del gusto en las élites costarricenses a fines del siglo XIX (1889-1896)
Authors: Hurtado Pimentel Ángela
Published: August 2017

El artículo detalla la relación visual entre las revistas ilustradas especializadas en moda, llamadas figurines, y la manera en que se expresaba un gusto “afrancesado” en la vestimenta de las clases altas en Costa Rica a finales del siglo XIX. Se basa en criterios de Pierre Bourdieu sobre el gusto y de Norbert Elias sobre el proceso civilizador para establecer las asociaciones entre la información que se diseminaba con los figurines y la adopción de ciertas modas en la Costa Rica finisecular. Se hace una revisión de un acopio privado de figurines de moda, que incluye las revistas La Estación, La Moda Elegante y La Revista Ilustrada de Nueva York, publicadas entre 1889 y 1896. Se compara la información presentada en estos figurines con avisos comerciales en los periódicos costarricenses y retratos fotográficos del mismo período.
Wasserfrauen auf Abwegen: Die Transformation des Rusalka-Motivs in der polnischen und russischen Popkultur
Authors: Lechner Elisabeth , Simonek Stefan , Tomala Marlena
Published: August 2017

Sirens became an essential element of the literary imagination in many European literatures in Romanticism and have remained popular ever since. Also, in Russian and Polish culture, the image of the dangerously alluring and transgressive female nymph called “rusalka” is omnipresent. In this paper, the authors use a comparative approach to trace the evolution of the “rusalka” motif from its creation in the Romantic period to its transformed (and often highly sexualized) use in present-day popular culture. From works written by Pushkin, Lermontov, Mickiewicz as well as Bal’mont and Gumilev (amongst others), we move on to contemporary actualizations of the motif in the music videos and lyrics of a Russian girl group (“Фабрика”), a Polish pop performer (Doda Elektroda) and a Russian folk-metal band (“Alkonost”). We argue that the centuries-old popularity of the “rusalka” motif can be ascribed to the theme’s core semantics of female transgression and adaptability that lends itself especially well to the sphere of pop and its remixing and resignifying practices.
Видовая «неопределенность» двувидовых глаголов как следствие морфемной немаркированности
Authors: Ясаи Ласло
Published: August 2017

The author analyzes biaspectual verbs with borrowed roots which have prefixed perfective or suffixed imperfective correlates. The analysis focuses on the change (the weakening or loss) of biaspectual semantics of these verbs.
The Kinship Terminology in Ruthenian, Slovak, and Serbian.
Authors: Fejsa Mihajlo
Published: August 2017

The aim of this paper is to present the kinship terminology in the Ruthenian language and compare it with the kinship terminology in Slovak and Serbian. Some 270 years ago, groups of Ruthenians began migrating south from their homeland in the Carpathian mountains mostly from Zemplen and Šaroš counties (in present-day Slovakia) to the Bačka region (in present-day Serbia). Since the Ruthenian language has been in contact both with the Slovak and Serbian languages for a long time, we expect to find certain influence of these languages on the Ruthenian kinship terminology.
Investigation of allergen proteins in five tomato cultivars
Authors: Mócsai R.T. , Maczó A. , Grünwald-Gruber C. , Majer-Baranyi K. , Adányi N. , Milotay P. , Czelecz J. , Tömösközi-Farkas R.
Published: August 2017

Investigation of putative allergens from tomato berries is challenging as differences between human serum IgE specificity and reactivity as well as the non-specific binding of the primary and secondary antibodies often cause difficulties. In this study five tomato cultivars were investigated to evaluate their potential allergenicity in Hungarian tomato sensitive patients. The major allergens proved to be low molecular weight proteins, but several previously described allergens could be identified as well using IgE-Western blotting. IgE binding to cross-reactive carbohydrate determinants (CCDs) was ruled out through the use of CCD inhibitor, but non-specific binding of the secondary antibody remained an issue. IgE binding activity of a purified, immunoblot positive protein (band at 40 kDa), and non-specific binding of the secondary antibody to the same protein, was demonstrated with an Optical Waveguide Lightmode Spectroscopy (OWLS) based immunosensor. LC-ESI-MS/MS analysis showed this protein is an as-yet undescribed vicilin-type putative allergen.
Governança das instituições educacionais metodistas
Authors: Rosa Luciano Sathler da , Ferreira Barros Davi
Published: August 2017

Resumo: Os autores destacam alguns aspectos relacionados às alterações recentes dos sistemas de governança das instituições educacionais metodistas brasileiras. Ressaltam o princípio de que a atuação na educação secular é um dos fundamentos da identidade metodista. Afirmam que a confessionalidade deve ser praticada de forma criativa e adequada ao contexto educacional, de acordo com os princípios wesleyanos. Dialogam com um artigo publicado pela Revista de Educação do Cogeime, em 2006, no qual apresentaram caminhos e desafios possíveis para o atual modelo de gestão educacional.
Dark Triad Dirty Dozen: Avaliando seus Parâmetros Via TRI
Authors: Medeiros Emerson Diógenes de , Monteiro Renan Pereira , Gouveia Rildésia Silva Veloso , Nascimento Bruna da Silva , Gouveia Valdiney Veloso
Published: August 2017

Resumo O presente estudo objetivou explorar os parâmetros psicométricos da Dirty Dozen por meio da Teoria de Resposta ao Item (TRI), utilizando o Modelo de Resposta Graduada. Participaram 284 pessoas, com média de idade de 24,2 anos (DP = 8,76). Inicialmente, checou-se a dimensionalidade da escala, sendo encontrados resultados que apoiam uma estrutura composta por três fatores oblíquos (CFI = 0,99; TLI = 0,98; RMSEA = 0,03). Portanto, as análises de TRI foram realizadas separadamente para cada fator. Posteriormente, verificou-se que os itens discriminam adequadamente os participantes, sendo aqueles que pertencem ao fator narcisismo os mais endossados; maquiavelismo e psicopatia exigiram uma quantidade maior de theta para haver concordância com o conteúdo do item, quiçá em virtude desses traços serem socialmente indesejáveis. Estima-se que os objetivos do estudo foram alcançados, conhecendo evidências dessa medida breve a partir da TRI, referendando seu uso em possibilidades futuras.