bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-analysis protocol for an observational study on the effects of adolescent sports participation on health in early adulthood
Authors: Kokandakar Ajinkya H. , Lin Yuzhou , Jin Steven , Weiss Jordan , Rabinowitz Amanda R. , May Reuben A. Buford , Small Dylan , Deshpande Sameer K.
Published: June 2024

Abstract: We will study the impact of adolescent sports participation on early-adulthood health using longitudinal data from the National Study of Youth and Religion. We focus on two primary outcomes measured at ages 23–28 — self-rated health and total score on the PHQ9 Patient Depression Questionnaire — and control for several potential confounders related to demographics and family socioeconomic status. Comparing outcomes between sports participants and matched non-sports participants with similar confounders is straightforward. Unfortunately, an analysis based on such a broad exposure cannot probe the possibility that participation in certain types of sports (e.g., collision sports like football or soccer) may have larger effects on health than others. In this study, we introduce a hierarchy of exposure definitions, ranging from broad (participation in any after-school organized activity) to narrow (e.g., participation in limited-contact sports). We will perform separate matched observational studies, one for each definition, to estimate the health effects of several levels of sports participation. In order to conduct these studies while maintaining a fixed family-wise error rate, we deployed an ordered testing approach that exploits the logical relationships between exposure definitions. Our study will also consider several secondary outcomes including body mass index, life satisfaction, and problematic drinking behavior.
Price Optimization Combining Conjoint Data and Purchase History: A Causal Modeling Approach
Authors: Valkonen Lauri , Tikka Santtu , Helske Jouni , Karvanen Juha
Published: June 2024

Abstract: Pricing decisions of companies require an understanding of the causal effect of a price change on the demand. When real-life pricing experiments are infeasible, data-driven decision-making must be based on alternative data sources such as purchase history (sales data) and conjoint studies where a group of customers is asked to make imaginary purchases in an artificial setup. We present an approach for price optimization that combines population statistics, purchase history, and conjoint data in a systematic way. We build on the recent advances in causal inference to identify and quantify the effect of price on the purchase probability at the customer level. The identification task is a transportability problem whose solution requires a parametric assumption on the differences between the conjoint study and real purchases. The causal effect is estimated using Bayesian methods that take into account the uncertainty of the data sources. The pricing decision is made by comparing the estimated posterior distributions of gross profit for different prices. The approach is demonstrated with simulated data resembling the features of real-world data.
Do women with a previous unintended birth subsequently experience missed opportunities for postpartum family planning counseling? A multilevel mixed effects analysis
Authors: Ujah Otobo I. , Salemi Jason L. , Rapkin Rachel B. , Sappenfield William M. , Daley Elen M. , Kirby Russell S.
Published: June 2024

Client-provider communication about family planning (FP) remains an important strategy for preventing unintended pregnancy. Yet, the literature lacks empirical studies examining whether and how women’s intendedness of a recent pregnancy may impact subsequent receipt of FP counseling. We investigated whether the intendedness of a recent pregnancy is associated with subsequent missed opportunities (MOs) for FP counseling, taking into account compositional and contextual factors. We performed a secondary analysis using pooled data from the 2016, 2017 and 2018 Performance Monitoring and Accountability 2020 cross-sectional surveys conducted in Nigeria, adjusting for complex design effects. Weighted multilevel logistic regression modeling was used to examine the relationships between pregnancy intention and MOs, overall and at the health facility, using two-level random intercept models. In the analytic sample of women within 24 months postpartum (N = 6479), nearly 60% experienced MOs for FP counseling overall and even 45% of those who visited a health facility visit in the past 12 months (N = 4194) experienced MOs. In the multivariable models adjusted for individual-/household- and community-level factors, women whose recent birth was either mistimed or unwanted were just as likely to have MOs for FP counseling as their counterparts whose pregnancy was intended (p > 0.05). Factors independently associated with a MOs include individual/household level factors such as level of education, exposure to FP media, household wealth index and contextual-level variables (geographic region). While evidence that pregnancy intendedness is associated with MOs for FP counseling remains inconclusive, efforts to mitigate these MOs requires prioritizing women’s prior pregnancy intentions as well as equipping healthcare providers with the capacity need to provide high-quality client-centered FP counseling, particularly for women whose recent birth was unintended.
Clinicopathological and prognostic implications of EGFR mutations subtypes in Moroccan non-small cell lung cancer patients: A first report
Authors: Boukansa Sara , Mouhrach Ismail , El Agy Fatima , El Bardai Sanae , Bouguenouch Laila , Serraj Mounia , Amara Bouchra , Ouadnouni Yassine , Smahi Mohamed , Alami Badreeddine , Mellas Nawfel , Benbrahim Zineb , El Fatemi Hinde
Published: June 2024

Background

Non-small cell lung cancer (NSCLC) remains a significant global health concern, with EGFR mutations playing a pivotal role in guiding treatment decisions. This prospective study investigated the prevalence and clinical implications of EGFR mutations in Moroccan NSCLC patients.

Methods

A cohort of 302 NSCLC patients was analyzed for EGFR mutations using multiple techniques. Demographic, clinical, and pathological characteristics were assessed, and overall survival (OS) outcomes were compared among different EGFR mutation subtypes.

Results

EGFR mutations were present in 23.5% of patients, with common mutations (81.69%) dominating. Common mutations showed strong associations with female gender and non-smoking status, while rare mutations were associated with a positive smoking history. Patients with EGFR mutations receiving tyrosine kinase inhibitors (TKIs) had significantly improved OS compared to wild-type EGFR patients. Notably, patients with common EGFR mutations had the highest OS, while those with rare mutations had a shorter survival period, albeit not statistically significant.

Conclusion

This study highlights the relevance of EGFR mutation status in NSCLC patients, particularly in therapeutic decision-making. The association between smoking history and rare mutations suggests the need for tailored approaches. The survival advantage for patients with common EGFR mutations underscores the significance of personalized treatment strategies.
Discovery of a potent, selective, and tumor-suppressing antibody antagonist of adenosine A2A receptor
Authors: Wang Linya , Garg Pankaj , Chan Kara Y. , Yuan Tom Z. , Lujan Hernandez Ana G. , Han Zhen , Peterson Sean M. , Tuscano Emily , Safavi Crystal , Kwan Eric , Villalta Mouna , Mathur Melina , Lai Joyce , Axelrod Fumiko , Souders Colby A. , Emery Chloe , Sato Aaron K.
Published: June 2024

New immune checkpoints are emerging in a bid to improve response rates to immunotherapeutic drugs. The adenosine A2A receptor (A2AR) has been proposed as a target for immunotherapeutic development due to its participation in immunosuppression of the tumor microenvironment. Blockade of A2AR could restore tumor immunity and, consequently, improve patient outcomes. Here, we describe the discovery of a potent, selective, and tumor-suppressing antibody antagonist of human A2AR (hA2AR) by phage display. We constructed and screened four single-chain variable fragment (scFv) libraries—two synthetic and two immunized—against hA2AR and antagonist-stabilized hA2AR. After biopanning and ELISA screening, scFv hits were reformatted to human IgG and triaged in a series of cellular binding and functional assays to identify a lead candidate. Lead candidate TB206-001 displayed nanomolar binding of hA2AR-overexpressing HEK293 cells; cross-reactivity with mouse and cynomolgus A2AR but not human A1, A2B, or A3 receptors; functional antagonism of hA2AR in hA2AR-overexpressing HEK293 cells and peripheral blood mononuclear cells (PBMCs); and tumor-suppressing activity in colon tumor-bearing HuCD34-NCG mice. Given its therapeutic properties, TB206-001 is a good candidate for incorporation into next-generation bispecific immunotherapeutics.
Gene expression and anticancer evaluation of Kigelia africana (Lam.) Benth. Extracts using MDA-MB-231 and MCF-7 cell lines
Authors: Kalsoom Aasia , Altaf Awais , Sattar Huma , Maqbool Tahir , Sajjad Muhammad , Jilani Muhammad Idrees , Shabbir Ghulam , Aftab Saira
Published: June 2024

In recent years, a cancer research trend has shifted towards identifying novel therapeutic compounds from natural assets for the management of cancer. In this study, we aimed to assess the cytotoxic activity of Kigelia Africana (KA) extracts on breast cancer (MDA-MB-231 and MCF-7) and noncancerous kidney cells (HEK-293T) to develop an efficient anticancer medication. We used gas chromatography mass spectrometry (GC-MS to analyze the constituents of EKA and HKA extracts meanwhile the crystal violet and the MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assays were used to examine the possible cytotoxic effects of plant extracts on our cancer cell lines along with non-cancerous control. The quantitative real-time PCR (RT-PCR) was run on cell samples to evaluate the differential expression of cell proliferative markers of cancer (BCL-2 and TP53). These phytochemicals have been reported to have binding affinity for some other growth factors and receptors as well which was evaluated by the in-silico molecular docking against Bcl2, EGFR, HER2, and TP53. Our Morphological observation showed a significant difference in the cell morphology and proliferation potential which was decreased under the effect of plant extracts treatment as compared to the control samples. The ethanol extract exhibited a marked antiproliferative activity towards MDA-MB-231 and MCF-7 cell lines with IC50 = 20 and 32 μg/mL, respectively. Quantitative RT-PCR gene expression investigation revealed that the IC50 concentration of ethanolic extract regulated the levels of mRNA expression of apoptotic genes. With the target and active binding site amino acids discovered in the molecular docking investigation, TP53/Propanoic acid, 3-(2, 3, 6-trimethyl-1, 4-dioxaspiro [4.4] non-7-yl)-, methyl ester (-7.1 kcal/mol) is the best-docked ligand. The use of this plant in folk remedies justifies its high in vitro anti-cancer capabilities. This work highlights the role of phytochemicals in the inhibition of cancer proliferation. Based on all these findings, it can be concluded that EKA extract has promising anti-proliferative effect on cancerous cells but more study is required in future to further narrow down the active ingredients of total crude extract with specific targets in cancer cells.
Development and validation of nomograms to predict survival of neuroendocrine carcinoma in genitourinary system: A population-based retrospective study
Authors: Niu Xiangnan , Sun Shiwei , Fan Wenjuan , Yue Peng , Yao Wei , Wang Yue , Deng Xiaoqian , Guo Fuyu , Zhang Yangang
Published: June 2024

Neuroendocrine carcinoma (NEC) is a rare yet potentially perilous neoplasm. The objective of this study was to develop prognostic models for the survival of NEC patients in the genitourinary system and subsequently validate these models. A total of 7125 neuroendocrine neoplasm (NEN) patients were extracted. Comparison of survival in patients with different types of NEN before and after propensity score-matching (PSM). A total of 3057 patients with NEC, whose information was complete, were extracted. The NEC influencing factors were chosen through the utilization of the least absolute shrinkage and selection operator regression model (LASSO) and the Fine & Gary model (FGM). Furthermore, nomograms were built. To validate the accuracy of the prediction, the efficiency was verified using bootstrap self-sampling techniques and receiver operating characteristic curves. LASSO and FGM were utilized to construct three models. Confirmation of validation was achieved by conducting analyses of the area under the curve and decision curve. Moreover, the FGS (DSS analysis using FGM) model produced higher net benefits. To maximize the advantages for patients, the FGS model disregarded the influence of additional occurrences. Patients are expected to experience advantages in terms of treatment options and survival assessment through the utilization of these models.
The impact of perinatal maternal stress on the maternal and infant gut and human milk microbiomes: A scoping review protocol
Authors: Ryan Niamh , Leahy-Warren Patricia , Mulcahy Helen , O’Mahony Siobhain , Philpott Lloyd
Published: June 2024

Objective

The objective of this scoping review is to review the research evidence regarding the impact of perinatal maternal stress on the maternal and infant gut and human milk microbiomes.

Introduction

Perinatal stress which refers to psychological stress experienced by individuals during pregnancy and the postpartum period is emerging as a public health concern. Early exposure of infants to perinatal maternal stress can potentially lead to metabolic, immune, and neurobehavioral disorders that extend into adulthood. The role of the gut and human milk microbiome in the microbiome-gut-brain axis as a mechanism of stress transfer has been previously reported. A transfer of colonised aberrant microbiota from mother to infant is proposed to predispose the infant to a pro- inflammatory microbiome with dysregulated metabolic process thereby initiating early risk of chronic diseases. The interplay of perinatal maternal stress and its relationship to the maternal and infant gut and human milk microbiome requires further systematic examination in the literature.

Inclusion criteria

This scoping review is an exploratory mapping review which will focus on the population of mothers and infants with the exploration of the key concepts of maternal stress and its impact on the maternal and infant gut and human milk microbiome in the context of the perinatal period. It will focus on the pregnancy and the post-natal period up to 6 months with infants who are exclusively breastfed.

Methods

This study will be guided by the Joanna Briggs Institute’s (JBI) methodology for scoping reviews along with use of the Prisma Scr reporting guideline. A comprehensive search will be conducted using the following databases, CINAHL Complete; MEDLINE; PsycINFO, Web of Science and Scopus. A search strategy with pre-defined inclusion and exclusion criteria will be used to retrieve peer reviewed data published in English from 2014 to present. Screening will involve a three-step process with screening tool checklists. Results will be presented in tabular and narrative summaries, covering thematic concepts and their relationships. This protocol is registered with Open Science Framework DOI 10.17605/OSF.IO/5SRMV.
O campesinato e o seu histórico papel na sociedade
Authors: Silva Alcimária Fernandes da , Silva Anieres Barbosa da
Published: June 2024

A compreensão do espaço agrário atual requer dos pesquisadores de todas as áreas do conhecimento, em especial da ciência geográfica, um aprofundamento teórico que esclareça a complexidade desse tema. Tendo como referência essa premissa, o artigo se propõe a analisar como teóricos clássicos abordaram o processo de expansão do capital no campo e as consequências para os camponeses. Na elaboração e estruturação do texto, foram necessários suportes bibliográficos, amparando-se principalmente em autores que fazem a leitura dessa problemática, como Kautsky (1980), Lênin (1982), Luxemburgo (1970) e Chayanov (1924; 1974). Com isso, foi possível identificar que no estudo do desenvolvimento do capital no campo, autores como Kautsky (1980) e Lênin (1982), através de uma perspectiva linear, acabaram por decretar o fim do campesinato. Entretanto, provando que a história está em movimento e que a ciência se constrói constantemente, pensadores como Rosa Luxemburgo (1970) e Chayanov (1974) justificaram a permanência e a importância do campesinato no capitalismo. Além disso, concluímos que esse aporte teórico tem subsidiado as interpretações de autores brasileiros contemporâneos, principalmente da Geografia, na leitura do espaço agrário.
Deutschlands Ernährungsstrategie: Gesund, nachhaltig, fair … und gut!
Authors: Wolff Nina
Published: June 2024

Preiskrise, Tierleid, Klima- und Bauernproteste: Das Thema Ernährung wird derzeit aus unterschiedlichen Gründen heiß diskutiert. Angesichts der negativen Auswirkungen unseres Einkaufs- und Ernährungsverhaltens ist ein Wandel dringend nötig. Anfang 2024 legte die Bundesregierung deshalb ihre Ernährungsstrategie für „Gutes Essen in Deutschland“ vor.
Die Weiterentwicklung der Sozialen Marktwirtschaft angesichts planetarer Belastungsgrenzen
Authors: Lange Sarah , Goldschmidt Nils
Published: June 2024

Die planetaren Belastungsgrenzen stellen auch das deutsche Wirtschafts- und Sozialsystem vor substanzielle Herausforderungen. In diesem­ Beitrag wird aufgezeigt, dass die Soziale Marktwirtschaft konzeptionell und praktisch das Potenzial hat, die ökologisch gebotenen Reformen umzusetzen und im Sinne individueller Lebenschancen zu gestalten.
Regional Disparity and Social-Economic Convergence in New Autonomous Regions in Banten Province
Authors: Amalia Fitri , Fitrijanto Arief
Published: June 2024

As a new province after separating from West Java province, Banten province has experienced various economic growth among its regions, which can reveal disparity in development. Some regions have abundant resources, productive human resources, and access to good economic activities, while others do not. This condition causes inequality between regions. Regional convergence analysis measures not only economic variables but also social measures, such as the Human Development Index (HDI), poverty, and unemployment. This study aims to analyze sigma and absolute beta convergence, in addition to measuring the speed of the new autonomous region (Daerah Otonom Baru/DOB) economic growth convergence in Banten. The study method for regional disparity uses coefficient of variation and klassen typology. The klassen typology approach was used to identify sectors. The results of this study show that disparities occur in regions/cities within the province. The GDRP per capita, HDI, poverty, and unemployment in each region from years 2015-2019 were analyzed using the analytical methods σ-convergence and β-convergence. Regional convergence also occurs, but it is not clear enough to show the possible rate distribution convergence in the future. Socioeconomic factors, including unemployment and poverty, have become factors that impact the rate convergence in the province. Meanwhile, the human resource quality factor does not significantly impact. The new autonomous region (DOB) strategy uses a developing regional strategy, while the parent region has a lagging status. The implication of this research is that each region needs to develop sectors according to its characteristics.
Integrated management of development in Functional Urban Areas. The case of metropolitan areas in Slovenia
Authors: Danielewicz Justyna
Published: June 2024

Metropolisation and globalisation have had a significant influence on space and development, both in terms of the physical and social aspects of the environment. Metropolitan areas have become engines of development, centres of economic activity, innovation, and culture, attracting people and businesses from all over the world. However, this concentration of people and activities has also resulted in significant challenges concerning management of their sustainable development. Most of today’s challenges are spread across administrative borders and working at the level of the metropolitan area can help develop innovative solutions that benefit the wider functional urban areas. Many of the problems faced by territories cut across sectors and effective solutions require an integrated approach to managing the development of functional urban areas (FUAs) and cooperation between the various authorities and stakeholders involved. The aim of this study is to evaluate the degree to which an integrated approach to development management is used in the management of metropolitan areas in Slovenia. The research focuses on FUAs of Ljubljana and Maribor. The results show that policy makers understand the need for integrated planning and management on a supralocal level. Local authorities commonly cooperate with each other using legitimate forms of institutionalising inter-municipal cooperation.
Polska rzeczpospolita samochodowa. Geografia samochodów osobowych w Polsce
Authors: Czasopisma Redakcja
Published: June 2024

Jest to praca zbiorowa pod redakcją Tadeusza Stryjakiewicza i Bartłomieja Kołsuta, napisana przez zespół autorów związanych z Zakładem Geografii Ekonomicznej w składzie (w kolejności alfabetycznej): Jakub Domagalski, Bartosz Doszczeczko, Wojciech Dyba, Bartłomiej Kołsut, Robert Kudłak, Michał Męczyński, Bartosz Stępiński i Tadeusz Stryjakiewicz. Książka ta jest pierwszą taką publikacją w Polsce – stanowi połączenie atlasu geograficznego i wiarygodnego źródła informacji z licznymi ciekawostkami dotyczącymi przemian, które zachodziły na rynku samochodowym w okresie transformacji systemowej i po akcesji naszego kraju do Unii Europejskiej.
Well‐controlled mucosal exudation of plasma proteins in airways with intact and regenerating epithelium
Authors: Persson Carl
Published: June 2024

Superficial, systemic microcirculations, distinct from the pulmonary circulation, supply the mucosae of human nasal and conducting airways. Non‐injurious, inflammatory challenges of the airway mucosa cause extravasation without overt mucosal oedema. Instead, likely reflecting minimal increases in basolateral hydrostatic pressure, circulating proteins/peptides of all sizes are transmitted paracellularly across the juxtaposed epithelial barrier. Thus, small volumes of extravasated, unfiltered bulk plasma appear on the mucosal surface at nasal and bronchial sites of challenge. Importantly, the plasma‐exuding mucosa maintains barrier integrity against penetrability of inhaled molecules. Thus, one‐way epithelial penetrability, strict localization, and well‐controlled magnitude and duration are basic characteristics of the plasma exudation response in human intact airways. In vivo experiments in human‐like airways demonstrate that local plasma exudation is also induced by non‐sanguineous removal of epithelium over an intact basement membrane. This humoral response results in a protective, repair‐promoting barrier kept together by a fibrin‐fibronectin net. Plasma exudation stops once the provisional barrier is substituted by a new cellular cover consisting of speedily migrating repair cells, which may emanate from all types of epithelial cells bordering the denuded patch. Exuded plasma on the surface of human airways reflects physiological microvascular‐epithelial cooperation in first line mucosal defense at sites of intact and regenerating epithelium.
Household Size and Access to Education in Rural Burundi: The Case of Mutaho Commune
Authors: Ndayishimiye Bosco , Manirakiza René , Kakuba Christian , Sindayihebura Jean François Régis , Barankanira Emmanuel
Published: June 2024

While education is recognized as a fundamental human right and an important factor in improving economic and social conditions, child schooling rates in Burundi show that there are still children of school-age who are not attending school and those who drop out very prematurely. This scientific study aims to highlight the relationship between household size and access to education in Mutaho commune (rural Burundi) by documenting the socio-demographic factors of the head of household likely to influence the schooling status of children aged 7–17. The hypothesis put forward in this study is that children’s schooling is influenced by household size. Data from a survey of 215 households in the Mutaho commune were analyzed using binomial logistic regression. The analysis shows that a large household size (OR = 5.463; p < 0.05; 95% CI: 1.311–22.771) is negatively associated with the education of children aged 7–17 living in Mutaho commune. Reducing fertility should be an integral concern for all those involved in the fields of population, education, and development.
Improved tag estimation method for TDMA anticollision protocols using CA-CFAR technique
Authors: Frahtia Abderrahmene , Benssalah Mustapha , Kifouche Abdenour , Drouiche Karim
Published: June 2024

Radio Frequency Identification (RFID) is considered a key element of the Internet of Things (IoT). It enables objects to be identified and tracked using radio waves. In RFID systems, several tags may be present within the range of the reader, leading to collisions and interference between signals that reduce system performance. Several anti-collision solutions have been proposed to solve this problem based on TDMA (Time-Division Multiple Access) technique, such as the ALOHA, Slotted ALOHA and Dynamic Framed Slotted ALOHA (DFSA) protocols. In this paper, we propose to improve TDMA anti-collision protocols based on the Cell Averaging Constant False Alarm Rate (CA-CFAR) scheme. The CA-CFAR technique is introduced to estimate the number of tags in the physical layer so that the reader can adjust its transmission parameters accordingly and avoid collisions. The obtained results show that this technique achieves good results in terms of system efficiency and the number of required slots to identify all the tags of the system.
Sodium titanium oxide/zinc oxide (STO/ZnO) photocomposites for efficient dye degradation applications
Authors: Zayed Mohamed , Nasr Mervat , Aljaafreh Mamduh J. , Marashdeh Mohammad , Al-Hmoud M. , Shaban Mohamed , Rabia Mohamed , Tarek Amna , Ahmed Ashour M.
Published: June 2024

In this study, sodium titanium oxide (Na2Ti3O7, termed STO) and sodium titanate/zinc oxide (STO/ZnO) photocomposites were prepared for the first time. A low-cost hydrothermal technique was employed to fabricate the STO/ZnO photocomposites with varying ZnO weight ratios: STO/0.25ZnO, STO/0.5ZnO, and STO/ZnO. The prepared photocomposites were investigated for the decomposition of methylene blue dye (MB) under natural visible light illumination and an artificial tungsten halogen lamp. The STO/ZnO photocomposite exhibits high photodegradation performance, which can be correlated with its properties and characterization. The X-ray diffraction analysis reveals that STO has an average crystallite size of 69.1 nm, ZnO has an average crystallite size of 41.4 nm, and the combination of STO/ZnO results in a reduced average crystallite size of 39.5 nm. The bandgap (E
g) of STO/ZnO is 2.53 eV after controlling the ZnO weight ratio. The photocatalytic efficiency of the STO/ZnO photocomposite was 100% for MB within 60 min of solar light irradiation, compared to 33.7% for STO and 25.8% for ZnO. The effect of STO/ZnO dosage and MB concentration was investigated. Furthermore, the kinetics and mechanisms of the photocatalytic process were examined. The results suggest that STO/ZnO has promising potential for practical applications in wastewater treatment.
Enhancing mechanical and rheological properties of HDPE films through annealing for eco-friendly agricultural applications
Authors: Yang Ning , Li Ying , Feng Liangshan , Liu Qi , Luo Qing , Liu Jialei
Published: June 2024

A composite of high-density polyethylene/ultra-high molecular weight polyethylene (HDPE/UHMWPE) was synthesized via a high-temperature melting process. We specifically examined the effects of annealing on the morphological and rheological properties of the composite. Using scanning electron microscopy and advanced rotational rheometry, we determined that annealing notably alters the composite’s microstructure, with a reduction in pronounced features post-treatment. Rheologically, UHMWPE content significantly enhanced mechanical properties, particularly in storage modulus (G′), loss modulus (G″), and complex viscosity (|η*|), which aligned with scaling law principles. Our findings highlight a distinct improvement in mechanical properties post-annealing, underscoring the potential of UHMWPE in enhancing polymer composite performance. The scaling laws relating G′, G″, and |η*| with UHMWPE were identified as follows: (1) pre-c
e: G′ ∼ c
0.2, g″ ∼ c
0.07, |η*| ～ c0.07 and (2) post-c
e: G′ ∼ c
1.20, g″ ∼ c
0.6, |η*| ∼ c
0.64, with a forward shift in c
e noted after annealing. The addition of UHMWPE significantly enhanced the system’s properties, particularly after annealing. This study offers crucial insights into optimizing HDPE plastic films for enhanced durability and sustainability, ideally suiting them for eco-friendly agricultural uses.
The power of memes: personification as a marker of psychological distance in memes about the war in Ukraine
Authors: Laineste Liisi , Fiadotava Anastasiya , Troitskiy Sergey , Castañar Guillem
Published: June 2024

Memes offer responsive acute commentary on controversial societal matters, providing non-violent and democratic spaces of discussion for conflicts. The paper studies memes on the war in Ukraine that spread in Eastern (Russia, Estonia, Belarus) and Western Europe (Spain). We analyze who are the main actors/characters that personify the war in the memes in these countries, how these characters are represented in memes, and what are the global and local aspects of their portrayal. Personification is seen as a marker for psychological distance of the meme-makers and sharers to the conflict.
Systematic literature review on intrusion detection systems: Research trends, algorithms, methods, datasets, and limitations
Authors: Issa Melad Mohammed , Aljanabi Mohammad , Muhialdeen Hassan M.
Published: June 2024

Machine learning (ML) and deep learning (DL) techniques have demonstrated significant potential in the development of effective intrusion detection systems. This study presents a systematic review of the utilization of ML, DL, optimization algorithms, and datasets in intrusion detection research from 2018 to 2023. We devised a comprehensive search strategy to identify relevant studies from scientific databases. After screening 393 papers meeting the inclusion criteria, we extracted and analyzed key information using bibliometric analysis techniques. The findings reveal increasing publication trends in this research domain and identify frequently used algorithms, with convolutional neural networks, support vector machines, decision trees, and genetic algorithms emerging as the top methods. The review also discusses the challenges and limitations of current techniques, providing a structured synthesis of the state-of-the-art to guide future intrusion detection research.
Green synthesis of copper oxide nanoparticles using genus Inula and evaluation of biological therapeutics and environmental applications
Authors: Alangari Abdulaziz , Aboul-Soud Mourad A. M. , Alqahtani Mohammed S. , Shahid Mudassar , Syed Rabbani , Lakshmipathy R. , Modigunta Jeevan Kumar Reddy , Jaiswal Harshita , Verma Meenakshi
Published: June 2024

In this research, we produced copper oxide nanoparticles (CuO NPs) using extracts from the entire above-ground portion of plants of genus Inula (Inula graveolens). The synthesis of CuO NPs was verified through various physicochemical analytical methods, including UV–visible, Fourier transform infrared, and transmission electron microscopy. The CuO NPs were found to be around 20 nm in size and spherical in shape. Subsequently, the synthesized compounds were evaluated for their anticancer properties. After treating A549 cells with CuO NPs at concentrations of 15 and 30 μg, we examined their cytotoxicity, lipid peroxidation activity (malondialdehyde level), and antioxidant activity (catalase, superoxide dismutase, and glutathione levels). Additionally, we analyzed the expression of apoptotic marker genes (p53, caspase-3, and caspase-9), cytokine levels (IL-6 and TNF-α), and DNA fragmentation. Our findings demonstrated that CuO NPs enhanced the expression of apoptotic genes, suggesting that phytochemical-derived NPs from Inula extracts induce apoptosis by upregulating tumor suppressor genes and downregulating oncogenes in A549 cells. Furthermore, CuO NPs exhibited higher susceptibility toward B. subtilis and S. aureus compared to ampicillin. Using the response surface methodology, we determined that CuO NPs are effective adsorbents for removing Pb2+ ions from aqueous solutions, making them promising for environmental applications. Overall, our results indicate that CuO NPs have potential as antimicrobial, antioxidant, and anticancer agents and as efficient adsorbents.
Sustainability analysis and decision-making strategy for swamp buffalo (Bubalus bubalis carabauesis) conservation in Jambi Province, Indonesia
Authors: Syarifuddin Hutwan , Afdal Muhammad , Yurleni Yurleni  , Hamidah Afreni , Devitriano Dodi , Poy Tee Tuan
Published: June 2024

The objective of this study is to analyze the sustainability of swamp buffalo cultivation and develop decision-making strategies. Data were collected through focus group discussions with key informants in swamp buffalo cultivation and surveys of buffalo farmers in three regencies in Jambi Province. This study examines 37 attributes contained in four dimensions: ecological, economic, social, and technological dimensions. Data were analyzed using multidimensional scaling through the Rapid appraisal for buffalo technique and analytical hierarchy process (AHP) The results showed that the sustainability index of swamp buffalo cultivation in Sarolangun Regency was 59.39%, Batanghari 58.23%, and Tebo 55.93%. This study identified 12 leverage attributes obtained from 37 attributes that affect the sustainability of swamp buffalo, i.e., forage feed, agricultural waste, land use, agricultural infrastructure, land ownership, buffalo manure, buffalo ownership, livestock motivation, environmental impact, agricultural waste treatment, land processing, and post-harvest technology. Then, from the results of four-dimensional weighting with 12 attributes using AHP, there are 5 alternative strategies in decision making, namely, (1) build internet network infrastructure, (2) determine the number of livestock that can be raised in an area, (3) establish buffalo farming institutions, (4) prevent land use conflicts, and (5) increase farmer participation in raising buffalo livestock. This research provides input to policy makers to develop swamp buffalo cultivation by considering ecological, economic, social, and technological dimensions.
Introduction to the special issue: Culturally sensitive approaches to conceptualization and treatment of psychiatric disorders
Authors: Pinciotti Caitlin M. , Wiese Andrew D.
Published: June 2024

Cognitive-behavioral therapy (CBT) is an effective treatment for a variety of psychiatric disorders. However, historic underrepresentation, misapplication of techniques, and neglected consideration for the unique experiences of marginalized groups—including racial, ethnic, sexual, and gender minorities—have led to mistrust of mental health treatment among these communities and decreased access to quality, evidence-based care. Although these treatments are not inherently harmful to individuals with marginalized identities, clinicians can cause harm if they do not consider the role of culture in their conceptualization, assessment, and treatment of individuals with marginalized identities. Thus, this Special Issue details important considerations for conceptualization, assessment, treatment, and research related to a variety of psychiatric disorders in individuals with marginalized identities. In particular, this Special Issue describes substance use disorders among Black men, eating disorders among queer and transgender individuals, obsessive-compulsive disorder in Hispanic and Latin American individuals, and social anxiety disorder in Black adolescents.
Eating disorders among queer and trans individuals: Implications for conceptualization, assessment, and treatment
Authors: Cusack Claire E. , Silverstein Scout , Askew Autumn J. , Simone Melissa , Galupo M. Paz , Levinson Cheri A.
Published: June 2024

Eating disorders (EDs) have been traditionally viewed as a disorder affecting cisgender, heterosexual women. Yet, the prevalence of EDs among queer and trans (QnT) individuals, coupled with the lack of interventions that attend to contextual factors related to sexual orientation and gender identity, underscore a critical health disparity issue requiring urgent attention. Here, we first review factors pertaining to QnT individuals’ minoritized sexual and gender identities that are important to consider in ED conceptualization for this population (e.g., minority stressors, identity-based body image standards). Next, we describe problematic assumptions present in existing ED assessment and propose more inclusive approaches. Lastly, we provide suggestions for practices that providers can implement within their treatment of EDs among QnT individuals.
Natural resources and the underground economy: A cross-country study in ASEAN using Bayesian approach
Authors: Nguyen Thach Ngoc , Duong My Ha Tien , Nguyen Diep Van
Published: June 2024

The development of the underground economy can significantly affect a country’s economic indicators. Although there have been different studies on this phenomenon, many aspects of underground activities remain incompletely defined. Therefore, the current research aims to supplement the existing literature by analyzing the link between abundant natural resources and the scope of the underground economy. To accomplish this objective, we collected panel data from ten Association of Southeast Asian Nations (ASEAN) countries during the period 1991–2018. We then employed the Bayesian regression estimator to look into the influence of natural resources wealth on the scope of the underground sector. We found that the former can negatively and strongly affect the latter in ASEAN countries. That is, natural resources might be a blessing rather than a curse for economic growth and development in these countries. Other variables were found to have a strong positive relationship with the underground economy, like trade openness, tax burden, size of government, corruption, and the global financial crisis. Meanwhile, GDP growth, urbanization, and political stability had a strong negative effect on the size of the underground economy. These findings provide some implications for the governments of ASEAN countries to perform appropriate measures to control the underground economy.
Decision-making on the job choice in the condition of Slovak households
Authors: Kollar Jan , Kika Marian , Mazurova Barbora
Published: June 2024

Getting, keeping as well as changing jobs are the moments in a person’s life associated with not only the search and evaluation of the options but also with selection and decision-making. The article is one of the few in the Slovak Republic that deals with the issue of decision-making on the job choice in households, thus bringing new point of view into the knowledge about the Slovak labor market. The aim of the article is to analyse the decision-making process on the job choice of members of Slovak households and to identify the decision-making circumstances. It deals with the three selected parts of the decision-making process: the decision-making steps, the decision-making subject (decision-maker) and the decision-making circumstances. The contribution is based on the theoretical background concerned to decision-making, paid work and specific conditions of households and it draws the knowledge from the results of the original national research in more than 500 Slovak households. The primary data was collected through an anonymous survey, using a standardised anonymous questionnaire and guided interviews. Statistical sorting and descriptive statistics were used in data processing using the statistics software SPSS. The chi-square test was used to verify the representativeness of the research sample. The results show that the closer the final decision, the higher the proportion of individuals who implement decision-making actions. The most important decision-making circumstances include financial valuation, the character (difficulty) of the work and the childcare.
Medical device regulation and its impact on the industry: A case study of Czech companies
Authors: Maci Jan , Matejicek Martin , Peter Lukas , Lefley Frank , Maresova Petra
Published: June 2024

The implementation of regulations is often seen as a necessary tool to mitigate market failures and safeguard consumer interests. The Medical Device Regulation (MDR) is a recent regulation specifically designed for the production of medical devices, aiming to ensure their safety and effectiveness. This article focuses on Czech companies and seeks to examine and quantify the effects of the MDR on their operations, considering both economic and procedural impacts. Through the analysis of primary and secondary data, this study endeavors to shed light on the repercussions of the MDR on the companies in question. The findings suggest that the MDR will have a negative impact on the profitability of these companies, consequently influencing their operational strategies. One key factor contributing to this negative outcome is the inability of the companies to transfer the increased costs resulting from regulatory requirements to their customers. As a result, affected companies are forced to make adjustments to their product portfolios, reducing their range of offerings. The research reveals that the perception of the MDR among the companies is predominantly negative. This negative sentiment arises primarily due to the financial burdens imposed by the regulation and the other associated impacts discussed in the article. Furthermore, the MDR is not perceived as a catalyst for innovation within the industry. By quantifying the effects of the MDR on Czech companies, this article provides valuable insights into the real-world implications of this regulatory framework. The findings highlight the challenges faced by companies in adapting to and complying with the MDR, particularly in terms of its impact on profitability and product offerings. This research serves as a reminder of the complex interplay between regulations, economic outcomes, and industry dynamics. Ultimately, it emphasizes the importance of considering the potential ramifications of regulations and their effects on businesses and markets.
An attempt to resolve no-wait flow shop scheduling problems using hybrid ant colony and whale optimization algorithms
Authors: Rostamzadeh Reza , Gholipour Arezou , Komari Alaei Mohammad Reza , Zavadskas Edmundas Kazimieras , Saparauskas Jonas
Published: June 2024

The incentive for many developments and scientific progresses within the field of scheduling has emerged from industrial environments, and naturally, it could be utilized in expressing the scheduling concepts regarding terms used in the industry. Generally speaking, scheduling problems are known as limited optimization issues through which decisions related to the machines’ assignment and works processing sequence are probed. Thus, following a review of the related literature, the major goal of this research is to design a mathematical model and to solve it through a meta-heuristic for no-wait flow shop scheduling problem using different machines for the purpose of minimizing the time required to complete the work using whale and ant colony optimization (ACO) algorithms in Sanat-Gostar-e-Hamgam Shoe Company. The ACO and whale algorithm methods are used to compare and predict scheduling activities in manufacturing line of shoe industry. The results showed an ACO algorithm with two stages in mean ideal distance (MID) end amounting to 76.65 and 77.38, respectively. Also, regarding the amounts of standard error mean squares, it could be claimed that the model designed using the improved whale algorithm has a better prediction, and the minimum time required to complete works using the whale algorithm is estimated to be equal to 86.1071. This could lead to an optimal state in achieving the predetermined goals.
Intersectional Incoherence: Zainichi Literature and the Ethics of Illegibility
Authors: Textor Cindi
Published: June 2024

Intersectional Incoherence stages an encounter between the critical discourse on intersectionality and texts produced by Korean subjects of the Japanese empire and their postwar descendants in Japan, known as Zainichi Koreans. Arguing for intersectionality as a reading method rather than strictly a tool of social analysis, Cindi Textor reads moments of illegibility and incoherent language in these texts as a product of the pressures on Zainichi Koreans and their literature to represent both Korean difference from and affinity with Japan. Rejecting linguistic norms and representational imperatives of identity categories, Textor instead demands that the reader grapple with the silent, absent, illegible, or unintelligible. Engaging with the incoherent, she argues, allows for a more ethical approach to texts, subjects, and communities that resist representation within existing paradigms.
Examining the UTAUT Framework in Understanding the Perception-Intention Dynamics of Accounting Information Systems in the Age of Industry 4.0
Authors: Asrori Asrori , Amal Muhammad Ihlasul
Published: June 2024

Purpose: This research investigates the relationship between students' perceptions of a digital accounting laboratory and their intention to utilize it. This research is conducted in response to the challenges and opportunities posed by the Fourth Industrial Revolution and the Digital Economy.Method: The study adopts the Unified Theory of Acceptance and Use of Technology (UTAUT) to understand and explain the factors influencing students' intention to use the Digital Accounting Laboratory. Data were collected from students in the Department of Accounting at the Faculty of Economics and analyzed using SEM-PLS statistical method.Findings: The research findings indicate that students' intention to utilize the Digital Accounting Laboratory for project-based learning, to enhance their competency in digital accounting during the era of the Industrial Revolution 4.0 and the Digital Economy is significantly high. The intention is positively influenced by performance expectations, effort expectancy, social influences, and facilitating conditions. Furthermore, the use of Digital Accounting Laboratories contributes to improving students' competence in digital accounting, aligning with the needs of business entities in the Industrial Revolution 4.0 era and the Digital Economy.Novelty: This research contributes to the field by providing insights into developing and utilizing digital technologies in accounting education. Establishing a Digital Accounting Laboratory and its positive impact on students' intention and competence in digital accounting offer new perspectives for adapting to the challenges and opportunities of the Industrial Revolution 4.0 and the Digital Economy.