bluuebunny/crossref_metadata_2025 huggingface dataset:
Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Authors: Ishikuro Mami , Obara Taku , Hasegawa Mayu , Murakami Keiko , Ueno Fumihiko , Noda Aoi , Onuma Tomomi , Matsuzaki Fumiko , Iwama Noriyuki , Kikuya Masahiro , Sugawara Junichi , Azegami Tatsuhiko , Nakayama Takashin , Mito Asako , Arata Naoko , Metoki Hirohito , Kanda Takeshi , Kuriyama Shinichi
Published: October 2024

Hypertensive disorders of pregnancy can cause hypertension in the future. Understanding how the blood pressure values of women with and without hypertensive disorders of pregnancy differ will facilitate follow-up blood pressure monitoring in clinical settings. This study investigated the association between hypertensive disorders of pregnancy and subsequent high blood pressure and hypertension. This study used Japanese data from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Follow-up systolic and diastolic blood pressures in normotensive women during pregnancy and those with hypertensive disorders of pregnancy were estimated using analysis of covariance adjusted for women with low birthweight, history of gestational diabetes mellitus, age, body mass index, pulse rate, smoking and drinking at the follow-up assessment, paternal hypertension history, and maternal hypertension or hypertensive disorders of pregnancy history. Finally, we performed a multiple logistic regression analysis. In total, 7343 women were included in the analysis. Women with a history of hypertensive disorders of pregnancy had higher blood pressure approximately three years postpartum compared with normotensive women. Hypertensive disorders of pregnancy in the most recent pregnancy in different subgroups, such as nulliparous women, multiparous women without a history of hypertensive disorders of pregnancy, and multiparous women with a history of hypertensive disorders of pregnancy, were associated with an increased risk of subsequent hypertension. Women’s birthweight was also weakly associated with hypertension. Even one experience of hypertensive disorders of pregnancy may contribute to elevated blood pressure and hypertension approximately three years postpartum. In addition, women’s birthweights may have a weak relationship with increasing blood pressure.
Filovirus vaccines as a response paradigm for emerging infectious diseases
Authors: Marzi Andrea , Feldmann Heinz
Published: October 2024

Nowadays, filovirus vaccine development may be seen as a paradigm for our response capabilities to emerging and re-emerging infectious diseases. Specifically, the West African Ebola virus disease (EVD) epidemic accelerated countermeasure licensure for several vaccine and therapeutic products. Those products have been successfully used to control EVD outbreaks in Central Africa over the past years. This positive development, however, has not yet reached beyond EVD. Therefore, it is pertinent to increase our efforts in the development of countermeasures for other human pathogenic members of the family Filoviridae as they continue to threaten public health in Sub-Saharan Africa. This review article summarizes the current filovirus vaccines in preclinical macaque studies and human clinical trials and discusses the most promising recent advancements.
Recombinant RSV G protein vaccine induces enhanced respiratory disease via IL-13 and mucin overproduction
Authors: Kawahara Eigo , Senpuku Kota , Kawaguchi Yoshino , Yamamoto Shinya , Yasuda Koubun , Kuroda Etsushi , Ouji-Sageshima Noriko , Ito Toshihiro , Hirai Toshiro , Shibata Takehiko , Yoshioka Yasuo
Published: October 2024

The G protein expressed on the surface of respiratory syncytial virus (RSV) is important for adhesion to host cells and as a vaccine target antigen. The corresponding vaccines can effectively eliminate RSV. However, they exacerbate pulmonary immunopathology including eosinophilic infiltration in the lungs after an RSV challenge in animal models, raising concerns about enhanced respiratory disease (ERD); thus, approaches that mitigate these effects are urgently needed. Herein, we aimed to examine the mechanisms of G protein vaccine-induced ERD in mice, using recombinant G protein as a vaccine antigen. After the RSV challenge, G protein-vaccinated mice exhibited lung weight gain, lung tissue damage, and increased infiltration of eosinophils, neutrophils, and CD4+ T cells into the lungs. We set lung weight gain as the endpoint for ERD and examined the impact of each infiltrating cell on lung weight gain. We observed that CD4+ T cells, but not eosinophils or neutrophils, that infiltrate the lungs are responsible for lung weight gain. In addition, T helper 2 cell-mediated IL-13 induced mucin hypersecretion and lung weight gain. Mucin hypersecretion may contribute to weight gain in the lungs. In conclusion, our results indicate a novel mechanism of G protein vaccine-induced ERD via IL-13 and mucin hypersecretion, which could lead to the development of safe G protein vaccines and the elucidation of the causes of ERD associated with other vaccines.
Nitrogen fixation in the North Atlantic supported by Gulf Stream eddy-borne diazotrophs
Authors: Hoerstmann Cora , Aguiar-González Borja , Barrillon Stéphanie , Carpaneto Bastos Cécile , Grosso Olivier , Pérez-Hernández M. D. , Doglioli Andrea M. , Petrenko Anne A. , Carracedo Lidia I. , Benavides Mar
Published: October 2024

Mesoscale oceanic eddies contribute to the redistribution of resources needed for plankton to thrive. However, due to their fluid-trapping capacity, they can also isolate plankton communities, subjecting them to rapidly changing environmental conditions. Diazotrophs, which fix dinitrogen (N2), are key members of the plankton community, providing reactive nitrogen, particularly in large nutrient-depleted regions such as subtropical gyres. However, there is still limited knowledge about how mesoscale structures characterized by specific local environmental conditions can affect the distribution and metabolic response of diazotrophs when compared with the large-scale dynamics of an oceanic region. Here we investigated genetic diazotroph diversity and N2 fixation rates in a transect across the Gulf Stream and two associated eddies, a region with intense mesoscale activity known for its important role in nutrient transport into the North Atlantic Gyre. We show that eddy edges are hotspots for diazotroph activity with potential community connectivity between eddies. Using a long-term mesoscale eddy database, we quantified N2 fixation rates as up to 17 times higher within eddies than in ambient waters, overall providing ~21 µmol N m−2 yr−1 to the region. Our results indicate that mesoscale eddies are hotspots of reactive nitrogen production within the broader marine nitrogen cycle.
Demonstration of high-frequency self-pulsing oscillations in an active silicon micro-ring cavity
Authors: Shetewy Abdou Eltamimy , Catuneanu Mircea Traian , He Menglong , Jamshidi Kambiz
Published: October 2024

We experimentally investigated the self-pulsing (SP) oscillations induced by the thermo-optic, free carrier, and Kerr nonlinear effects in integrated active silicon microring resonators. We demonstrate high frequency self-pulsing oscillations (up to 30 MHz) by applying a few millivolts of reverse bias voltage to the PIN junction of the active cavity. We illustrate that the shape of those oscillations (i.e., frequency and duty cycle) can be controlled by adjusting the CW input power and applying a reverse bias voltage to the PIN junction for carrier removal. This controlling is important for synchronizing the cavity which is crucial for neural network applications. Furthermore, we utilize a mathematical model for visualizing the stability regions by numerically studying coupled mode theory in silicon microcavity under different conditions.
Reducing inhomogeneous broadening of spin and optical transitions of nitrogen-vacancy centers in high-pressure, high-temperature diamond
Authors: Blinder Rémi , Mindarava Yuliya , Tran Thai Hien , Momenzadeh Ali , Yang Sen , Siyushev Petr , Sumiya Hitoshi , Tamasaku Kenji , Osaka Taito , Morishita Norio , Takizawa Haruki , Onoda Shinobu , Hara Hideyuki , Jelezko Fedor , Wrachtrup Jörg , Isoya Junichi
Published: October 2024

With their optical addressability of individual spins and long coherence time, nitrogen-vacancy (NV) centers in diamond are often called “atom-like solid spin-defects”. As observed with trapped atomic ions, quantum interference mediated by indistinguishable photons was demonstrated between remote NV centers. In high sensitivity DC magnetometry at room temperature, NV ensembles are potentially rivaling with alkali-atom vapor cells. However, local strain induces center-to-center variation of both optical and spin transitions of NV centers. Therefore, advanced engineering of diamond growth toward crystalline perfection is demanded. Here, we report on the synthesis of high-quality HPHT (high-pressure, high-temperature) crystals, demonstrating a small inhomogeneous broadening of the spin transitions, ofT2* = 1.28 μs, approaching the limit for crystals with natural13C abundance, that we determine asT2* = 1.48 μs. The contribution from strain and local charges to the inhomogeneous broadening is lowered to ~17 kHz full width at half maximum for NV ensemble within a > 10 mm3volume. Looking at optical transitions in low nitrogen crystals, we examine the variation of zero-phonon-line optical transition frequencies at low temperatures, showing a strain contribution below 2 GHz for a large fraction of single NV centers.
Multi-channel portable odor delivery device for self-administered and rapid smell testing
Authors: Hopper Richard , Popa Daniel , Maggioni Emanuela , Patel Devarsh , Obrist Marianna , Landis Basile Nicolas , Hsieh Julien Wen , Udrea Florin
Published: October 2024

To improve our understanding of the perception of odors, researchers are often required to undertake experimental procedures with users exposed to multiple odors in a variety of settings, including to diagnose smell loss in clinics and care homes. Existing smell tests are typically administered using multiple sniffing pens, manually presented to patients by a highly specialized nurse using a time-consuming and complex testing paradigm. Automated odor delivery devices, such as olfactometer systems, exist but are expensive, bulky and typically lab based, making them difficult to use for on the ground odor delivery. Here we have developed a portable, affordable, odor delivery device that can deliver 24 odors through individual channels with high temporal precision and without cross-contamination. The device allows for the rapid, flexible sequencing of odors via digital control using a mobile application and has been experimentally validated in the lab, as well as tested on patients. The design provides several advantages for investigating olfactory perception and offers the possibility that users can one day self-administer smell tests in a range of settings, including at home, allowing smell healthcare services to evolve and become part of a routine practice and self-care culture.
Serine phosphorylation mimics of Aβ form distinct, non-cross-seeding fibril morphs
Authors: Sanagavarapu Kalyani , Meisl Georg , Lattanzi Veronica , Bernfur Katja , Frohm Birgitta , Olsson Ulf , Knowles Tuomas P. J. , Malmendal Anders , Linse Sara
Published: October 2024

Left: One plane of an Aβ42 wt fibril with Ser8 and Ser26 marked. Right: Four aggregation time courses starting from a 1 : 1 mixture of Aβ42 wt and S26E, implying that the peptides fail to coaggregate and two separate types of fibrils are formed.
A strategy for detecting CSFV using DNAzyme-HCR cascade amplification
Authors: Cao Xiuen , Cai Jiajing , He Zhilin , Ji Haofei , Sun Ruowei , Zhang Xun , Chen Chuanpin , Zhu Qubo
Published: October 2024

The Hybridization Chain Reaction (HCR) is an isothermal amplification technique widely used for sensing nucleic acids and small molecules.
Real-time optical detection of mercury contamination in drinking water using an amphiphilic recognition probe at liquid crystal/aqueous interfaces
Authors: Pandey Satyabratt , Rashid Madeeha , Singh Vishal , Singh Garima , Patel Chandan Bhai , Verma Rohit , Dev Dharm , Singh Ranjan Kumar , Singh Sachin Kumar
Published: October 2024

A liquid crystal-sensing platform, leveraging N-dodecylamine-di-thiocarbamate (DDC), enables simple, sensitive, real-time and cost-effective detection of mercury in drinking water, aiding environmental pollution control.
Catalytic applications of organic–inorganic hybrid porous materials
Authors: Wang Maodi , Dai Huicong , Yang Qihua
Published: October 2024

Insights into the synergistic effects of different active sites of organic–inorganic hybrid porous materials for thermal- and photo-catalysis were discussed.
Zig-zag-fused π-extended BODIPYs via gold-catalysed cycloisomerisation
Authors: Ohashi Fumika , Takano Hideaki , Shinokubo Hiroshi
Published: October 2024

An efficient gold-catalysed intramolecular cycloisomerisation of BODIPYs provides seven-membered-ring-fused BODIPYs on the zig-zag edge. The fused π-extended BODIPYs exhibit unique photophysical properties including NIR absorption and emission.
Advances in perovskite-based photovoltaics and photocatalysis: a journey fueled by ChemComm
Authors: Mai Haoxin , Caruso Rachel A.
Published: October 2024

This Historical Reflections article shows the impact a selection of key communications in ChemComm have had in moving the study of perovskite-based materials forward in the areas of photovoltaics and photocatalysis.
Sn3S4: a new mixed-valence tin sulfide
Authors: Gajda Roman , Podsiadło Sławomir , Jastrzębski Cezariusz , Dłużewski Piotr , Woźniak Krzysztof
Published: October 2024

A new member of the family of tin chalcogenides has been synthesized and crystallized, and its structure was determined by single-crystal X-ray analysis. Sn3S4 is a mixed-valence compound with regular Fd3̄m space group symmetry.
Unravelling molecular interaction of the uranyl(vi) complex with bovine serum albumin
Authors: Behera Tankadhar , Sethi Sipun , Rout Jyotiprabha , Bag Bhawani Prasad , Behera Nabakrushna
Published: October 2024

Insight into the interaction of the uranyl(vi) complex with bovine serum albumin was gained through comprehensive spectroscopic and molecular docking studies.
Binding modes of a flexible ruthenium polypyridyl complex to DNA
Authors: Malagarriga Meritxell , González Leticia
Published: October 2024

Ruthenium(ii) polypyridyl complexes are attractive binders to DNA.
Wired for stability: evaluating the electrical performance of a solution-processed zinc oxide-modified silver nanowire transparent electrode
Authors: Lukic Jovan N. , Radmilovic Vuk V.
Published: October 2024

Excellent electrical stability protection via a fully solution processed transparent electrode based on zinc oxide nanoparticles and silver nanowires.
Bismuthene as a novel anode material of magnesium/zinc ion batteries with high capacity and stability: a DFT calculation
Authors: Isa Khan Muhammad , Khurshid Mahnaz , Alarfaji Saleh S. , Majid Abdul
Published: October 2024

In our research, we utilize density functional theory (DFT) to explore the properties of magnesium and zinc atoms adsorbed on bismuthene.
Computationally aided design of defect-appended aliphatic amines for CO2 activation within UiO-66
Authors: Pareras Gerard , Rimola Albert , Taddei Marco , Tiana Davide
Published: October 2024

We used computational chemistry to design new catalysts based on missing-clusters defective UiO-66 functionalised with aliphatic amine groups to adsorb CO2 transforming into carbamic acid.
MOF-derived N-doped CoNi@C as bifunctional catalysts for efficient water splitting
Authors: Yang Xihui , Li Zekun , Yang Zikun , Meng Dapeng , Wang Zhao
Published: October 2024

CoNi@C core–shell catalysts from ZIF-67 were synthesized for efficient water splitting. The hydrophilic carbon shell inhibits metal oxidation. The CoNi alloy serves as the active site, while nitrogen doping promotes the electrocatalytic performance.
A novel copper(ii) complex with a salicylidene carbohydrazide ligand that promotes oxidative stress and apoptosis in triple negative breast cancer cells
Authors: Paliwal Kumudini , Swain Abinash , Mishra Durga Prasad , Sudhadevi Antharjanam P. K. , Kumar Manjuri
Published: October 2024

A Cu(ii) complex binds and cleaves DNA effectively, exhibiting selective and significant cytotoxicity against breast cancer cells by the induction of intrinsic apoptosis, as evidenced by morphological changes and protein expression analysis.
Mechanistic insights into multimetal synergistic and electronic effects in a hexanuclear iron catalyst with a [Fe3(μ3-O)(μ2-OH)]2 core for enhanced water oxidation
Authors: Shen Zhi-Kai , Li Kang , Li Zi-Jian , Yuan Yong-Jun , Guan Jie , Zou Zhigang , Yu Zhen-Tao
Published: October 2024

A water-soluble hexanuclear iron(iii) complex can catalyze water oxidation in acidic aqueous solutions through reversible proton transfer on μ2-OH and multimetal synergistic spin variation.
Not so inert mer-tris-chelate cobalt(iii) complex of a hydroxy-pyridine functionalized NHC ligand for cyclic carbonate synthesis
Authors: Chowdhury Rhitwika , Bhat Irshad Ahmad , Sachan Sharad Kumar , Anantharaman Ganapathi
Published: October 2024

A robust mer-tris-Co(iii)-IMepyO catalyst was synthesized and utilized for diverse cyclic organic carbonate preparation.
Correction: Plasma-assisted fabrication of ultra-dispersed copper oxides in and on C-rich carbon nitride as functional composites for the oxygen evolution reaction
Authors: Benedet Mattia , Fasan Angelica , Barreca Davide , Maccato Chiara , Sada Cinzia , Deambrosis Silvia Maria , Zin Valentina , Montagner Francesco , Lebedev Oleg I. , Modin Evgeny , Rizzi Gian Andrea , Gasparotto Alberto
Published: October 2024

Correction for ‘Plasma-assisted fabrication of ultra-dispersed copper oxides in and on C-rich carbon nitride as functional composites for the oxygen evolution reaction’ by Mattia Benedet et al., Dalton Trans., 2024, https://doi.org/10.1039/d4dt02186j.
Influence of humic acid and UV-irradiation on iron-based nanoparticle toxicity in Girardia tigrina
Authors: Yadav Natasha , Nath Anurag , Singh Pushplata Prasad , Bohidar Himadri B. , Callahan Damien L. , Dujon Antoine M. , Afonso Luis O. B. , Schultz Aaron G.
Published: October 2024

The presence of humic acid and UV exposure influenced iron-based nanoparticle behaviour and toxicity to a freshwater planaria species.
A paired alkaline electrolyzer for furfural oxidation and hydrogen evolution over noble metal-free NiFe/Ni and Co/MXene catalysts
Authors: Liu Xiaopeng , Albloushi Mohammad , Galvin Michael , Schroeder Connor W. , Wu Yue , Li Wenzhen
Published: October 2024

A paired alkaline electrolyzer with non-noble metal catalysts was developed, demonstrating higher performances of furfural oxidation on NiFe/Ni foam at the anode and hydrogen evolution on Co/MXene at the cathode under practical current densities.
Acoustic enrichment of sperm for in vitro fertilization
Authors: Zhang Chunqiu , Rong Ning , Lin Ziyi , Li Peng-Qi , Shi Jingyao , Zhou Wei , Niu Lili , Li Fei , Tang Rongxin , Li Lei , Meng Long
Published: October 2024

This study introduces an acoustofluidic device that leverages acoustic streaming to efficiently accumulate sperm. Importantly, ultrasound significantly improves sperm motility, increases fertilization rates and accelerates multicellular development.
Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials
Authors: Shekhar  , Chowdhary Shefali , Mosnier Joel , Fonta Isabelle , Pradines Bruno , Kumar Vipan
Published: October 2024

In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
Recent advances from computer-aided drug design to artificial intelligence drug design
Authors: Wang Keran , Huang Yanwen , Wang Yan , You Qidong , Wang Lei
Published: October 2024

CADD and AIDD contribute to the drug discovery.
Natural product-inspired [3 + 2] cycloaddition-based spirooxindoles as dual anticancer agents: synthesis, characterization, and biological evaluation by in vitro and in silico methods
Authors: Nivetha Narayanasamy , Don Hamid Jevid , Simha N Akshaya , Devegowda Devanand , Ramu Ramith , Velmathi Sivan
Published: October 2024

A newly synthesized spirooxindole pyrrolothiazole derivative exhibited promising anticancer activity against both breast and colorectal cancer cells.
Dual responsive fluorescence switching of organohydrogel towards base/acid
Authors: Dixit Manish Kumar , Mukherjee Moupia , Sahu Bharat Kumar , Kalam Abul , Dubey Mrigendra
Published: October 2024

Herein, we report a dual acid/base responsive fluorescent and simultaneous reversible phase transformative organohydrogel (OHG).
Fully bio-based water-resistant wood coatings derived from tree bark
Authors: Wang Fengyang , Morsali Mohammad , Rižikovs Jānis , Pylypchuk Ievgen , Mathew Aji P. , Sipponen Mika H.
Published: October 2024

A fully bio-based and water-resistant wood surface protection system inspired by the natural barrier function of tree bark.
Flexible, self-healing and portable supramolecular visualization smart sensors for monitoring and quantifying structural damage
Authors: Jiao Dezhi , Gu Sihan , Cheng Li , Li Shuoqi , Liu Chengbao
Published: October 2024

A novel supramolecular damage sensor featuring unique ionic recognition, robust failure visualization and excellent environmental adaptability is constructed for monitoring and quantifying structural health.
Regular pentagonal folded La doped CoNiOOH@FeSe@NiSe/NF nanosheet array for high efficiency alkaline electrocatalytic oxygen evolution reaction
Authors: Lu Biaobiao , Yang Yaoxia , Zhang Yu , Zhang RuiRui , Zhou Fuxing , Wang Qingtao , Zeng Wei , Sun Dongfei
Published: October 2024

A heterostructure La-CoNiOOH@FeSe@NiSe electrode material was prepared on nickel foam by a simple hydrothermal method as an efficient and stable electrocatalyst for the oxygen evolution reaction in electrolytic water splitting.
Dinitromethyltetrazole (DNMT)-based energetic coordination polymers (ECPs) as lead-free primary explosives and laser initiators
Authors: Guo Jinkun , Huang Shiliang , Wei Liyuan , Lang Qing , Hao Wenjia , Xu Yuangang , Liu Yu , Lu Ming
Published: October 2024

A series of energetic coordination polymers has been synthesized by incorporating dinitromethyltetrazole with alkali metals (Na, K, Rb and Cs), which have potential applications in laser initiating high explosives.
Rhodium complexes bearing 2-(pyridin-2-yl)hydrazino acenaphthene-1-one: synthesis, structure and electrochemical studies
Authors: Bakaev I. V. , Komlyagina V. I. , Ulantikov A. A. , Romashev N. F. , Gushchin A. L.
Published: October 2024

In this work, synthetic routes for previously unknown Rh complexes with a redox-active 2-(pyridin-2-yl)hydrazino acenaphthene-1-one (Py-mhan) are proposed and their electrochemical behavior is investigated.
Palladium-catalyzed C–H bond activation and decarboxylation for the assembly of indolo[1,2-f]phenanthridine
Authors: Liu Xiaobing , Ban Yong-Liang , Liu Yanjie , Zhuang Mengdie , Zhou Yao
Published: October 2024

An expedient C–H activation strategy for the assembly of indolo[1,2-f]phenanthridine derivatives via a Pd-catalyzed decarboxylation tandem cyclization is presented.
P-Stereodefined morpholino dinucleoside 3′,5′-phosphorothioates
Authors: Jastrzębska Katarzyna , Antończyk Patrycja , Dolot Rafał
Published: October 2024

We present P-stereodefined morpholino phosphorothioate analogs and provide valuable structural insights into their stereochemistry. These P-diastereomerically pure analogs could have a significant impact in the field of nucleic acid therapeutics.
A general photocatalytic strategy for the synthesis of β-hydroxy acid derivatives from alkenes
Authors: Chen Meiling , Yang Jingjing , Xiao Wei , Chen Jian-Qiang , Wu Jie
Published: October 2024

A general and concise strategy to realize the photo-induced difunctionalization of alkenes to access β-hydroxy acid derivatives is developed.
Electrical stimulation: a novel therapeutic strategy to heal biological wounds
Authors: Preetam Subham , Ghosh Arka , Mishra Richa , Pandey Arunima , Roy Debanjan Singha , Rustagi Sarvesh , Malik Sumira
Published: October 2024

Electrical stimulation (ES) has emerged as a powerful therapeutic modality for enhancing biological wound healing.
Effect of accelerated aging on the thermo-mechanical behavior and biotribological properties of an irradiation cross-linked GO/UHMWPE nanocomposite after VE diffusion
Authors: Li Yinbiao , Duan Weipeng
Published: October 2024

The influence of accelerated aging on the thermo-mechanical behavior and biotribological properties of irradiation cross-linked GO/UHMWPE nanocomposite after VE diffusion was investigated, especially the biotribological properties.
Development of a disposable paper-based thin film solid-phase microextraction sampling kit to quantify ketone body
Authors: Mandal Debsmita , Dey Indrayani , Ghosh Chiranjit
Published: October 2024

Illustration for determination of β-hydroxybutyric acid ketone body by paper-based thin film solid-phase microextraction patches.
A metal ion and electrolyte free twin electrode photocapacitor possessing ultrafast charging capability
Authors: Surana Karan , Bariya Sanjay N. , Kanani Darshna B. , Soni Saurabh S.
Published: October 2024

CdSe quantum dots act as the photo-active material while a layered structure of rGO and TiO2 plays the role of a charge storage medium in the developed photocapacitor to achieve a capacitance of over 300 mF g−1.
Oxygen vacancies on CuGa2 catalysts enhance CO2 reduction to CO
Authors: Mou Jiangfeng , Hu Jin , Chen Tianyou , Wang Kaizhao , Wang Kaijun , Zhang WeiJun , Wu Shuai , Shi Jin , Zhao Pengchong
Published: October 2024

This study adopts a very simple and effective method to prepare the O–CuGa2 catalyst electrode enriched with oxygen vacancies. Its Faraday efficiency for CO production reaches as high as 82.6%.
Development of a dextrin–vitamin D3 micelle nanocarrier for the antimicrobial peptide LLKKK18 as a potential therapeutic agent for bone infections
Authors: Machado Alexandra , Gama Miguel , Martins José Alberto
Published: October 2024

In this work, an expedite synthesis was developed for a self-assembled micelle carrier for the antimicrobial peptide LL18.
AI-driven precision subcellular navigation with fluorescent probes
Authors: Zhu Yingli , Fang Yanpeng , Huang Wenzhi , Zhang Weiheng , Chen Fei , Dong Jie , Zeng Wenbin
Published: October 2024

AI-driven precision subcellular navigation with fluorescent probes.
Achieving high sensing sensitivity in a Dy3+ doped garnet phosphor toward optical thermometry
Authors: Long Shichang , Tian Minfeng , Zhang Dan , Luo Xixian , Xu Wen , Tian Ying , Xin Shuangyu
Published: October 2024

We report on a highly sensitive optical temperature sensing material based on two thermally coupled energy levels (4I15/2 and 4F9/2) of Dy3+.
Amide-functionalized lanthanide metal–organic frameworks: smart double ratiometric fluorescence sensing of thiodiglycolic acid and tunable luminescence
Authors: Zhang Xu , Yu Jiahui , Li Xin , Jiao Chengqi , Zhu Yanyu , Zheng Hanwen , Sun Zhengang
Published: October 2024

Two series of isostructural Ln-MOFs and Ln-doped MOFs were synthesized. Tb-DMF and Tb-DMA are the first to achieve double ratiometric fluorescence sensing of TDGA in real urine. Meanwhile, the doped Ln-MOFs achieve the regulation of emission colors.
Cardiac-derived CTRP9 mediates the protection of empagliflozin against diabetes-induced male subfertility in mice
Authors: Mu Yang , Luo Ling-Bo , Huang Rong , Shen Zhuo-Yu , Huang Dan , Zhao Shu-Hong , Yang Jing , Ma Zhen-Guo
Published: October 2024

Previous studies have shown beneficial effects of empagliflozin (Empa), a selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), on diabetes and cardiovascular outcomes in patients with diabetes. However, whether Empa could ameliorate diabetes mellitus (DM)-induced male spermatogenesis dysfunction remains unclear. Our study aimed to investigate the effect of Empa in the development of DM-induced male spermatogenesis dysfunction and to reveal the molecular mechanisms. DM mice were orally treated with Empa to investigate the effects of Empa on DM-induced male mice spermatogenesis dysfunction. We employed a cardiac-specific C1q/tumor necrosis factor-related protein 9 (CTRP9)-deficient mouse model and a cardiac-specific CTRP9 overexpression mouse model to investigate its role in the protection of Empa against diabetes-induced male subfertility. We found that Empa treatment could improve DM-induced male mice subfertility. Interestingly, we discovered that cardiac-derived CTRP9 was decreased in DM mice and this decrease was prevented by Empa treatment. A CTRP9 blocking antibody or cardiac-specific depletion of CTRP9 abolished the protection of Empa on DM-induced male subfertility. Cardiac-specific CTRP9 overexpression ameliorated DM-induced male subfertility. Mechanistically, we identified that cardiac-derived CTRP9 increased steroidogenesis in mice with diabetes in a PKA-dependent manner. We also provided direct evidence that activation of AMP activated protein kinase α (AMPKα)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signalling pathway by CTRP9 was responsible for the attenuation of ferroptosis in Leydig cells. In conclusions, we supposed that Empa was a potential therapeutic agent against DM-induced male mice spermatogenesis dysfunction.
An Effective Interprofessional Collaboration to Support African Refugee Students' Oral and Written Language and Social Integration
Authors: Karasinski Courtney , Niu-Cooper Rui
Published: October 2024

Purpose:

Two faculty members collaborated to advance educational equity by providing a summer camp experience to prevent summer learning loss for African refugee students in preschool through high school. Both faculty members educate university students in graduate programs, one for students aiming to become educators of English to Speakers of Other Languages and the other for speech-language pathology students.

Method:

Speech-language pathology graduate students provided supports for oral and written language within Tier 1 of a multitiered systems of support framework during camp. Interventions were provided within the context of the camp activities, rooted in the constructs of contextualized intervention, implicit learning, and feedback-free learning. The speech-language pathology students collaborated with the faculty members, camp director, community members, and the campers.

Results:

The speech-language pathology students learned to provide language support in natural environments, analyze writing, recognize strengths and areas for growth in multilingual learners, establish rapport with individuals from cultural and linguistic backgrounds that differ from their own, collaborate with other professionals, and build campers' confidence and self-esteem. The campers expanded their vocabulary, syntactic, and narrative production and developed teamwork, collaboration, and leadership.

Conclusions:

This program can be a model for others aiming to collaborate to advance educational equity. Speech-language pathologists have an important role in collaborating with colleagues from other disciplines to provide programs for language and literacy support, even when the students do not have underlying language disorder.
Comparison of permanent magnet synchronous machine and permanent magnet flux‐modulated machine in direct drive considering number of rotor poles
Authors: Abareshi Saeed , Faiz Jawad , Ghods Mehrage
Published: October 2024

Direct drive permanent magnet (PM) motors have become a very attractive choice for electric vehicles. Generally, PM motors are divided into PM synchronous motors (PMSMs) and PM flux‐modulated motors (PMFMMs). High torque density is the main requirement of direct drive motors, therefore, the structure of conventional PM motors is modified to boost the torque. Increasing the number of poles is a structural modification to achieve high torque density in PMSMs; however, a large number of poles affects motor characteristics such as power factor, flux weakening, losses, and efficiency. The other way to have high torque is to use PMFMMs, which have a high intrinsic torque density. This paper first compares the performance of PMSMs with different number of poles. Then the performance of PMFMMs and PMSMs are compared to show their differences. The performance of PMFMMs with different teeth modulators and magnetic gear ratios are predicted to show their effects upon its performance. The simulation results using finite elements method|finite element method (FEM) are presented, and finally, a PMFMM with 36 slots and 40 poles as case study is subjected to an experimental test and its results are compared with FEM.

The cover image is based on the article Comparison of permanent magnet synchronous machine and permanent magnet flux‐modulated machine in direct drive considering number of rotor poles by Saeed Abareshi et al., https://doi.org/10.1049/elp2.12500.
Analysis and control design for input‐series output‐parallel multi‐channel inductive power transfer system
Authors: Wang Leyu , Sun Pan , Liang Yan , Wu Xusheng , Deng Qijun , Rong Enguo
Published: October 2024

To realize high‐power inductive power transfer (IPT) for fast charging of electric vehicles (EVs), an input‐series output‐parallel (ISOP) multi‐channel IPT system is analysed in this paper, and an output control strategy based on single neuron controller is proposed to improve the stability of the system. Firstly, the steady‐state operating conditions of ISOP‐IPT system is analysed based on different compensation networks which shows that the constant‐voltage‐output compensation networks are more suitable for the proposed circuit structure. Then, to improve the voltage equalization between channels, an open‐loop control method combining parameter design and phase‐shift control is proposed against different coil misalignments. At the same time, based on the single neuron controller, the system output closed‐loop control is realized without the need of accurate system modelling. Finally, a three‐channel ISOP‐IPT experimental system was constructed, which operated stably at 2.9 kW with a power efficiency of 93.38%. The system closed‐loop control with control time of 22 ms is realized. The voltage equalization control offset is less than 1%.
Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis
Authors: Wang Shaoqiang , Wang Yifan
Published: October 2024

This article used network pharmacology, molecular docking, GEO analysis, and Gene Set Enrichment Analysis to obtain 38 main chemical components and 66 corresponding targets involved in Alzheimer's disease (AD) treatment in "Cistanche deserticola‐Polygala". Through further Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes enrichment analysis, we obtained AD signalling pathways, calcium signalling pathways, and other signalling pathways related to the treatment of AD with “Cistanche deserticola‐Polygala”. Molecular docking showed that most of the core chemical components had good binding ability with the core targets. This article aims to reveal the mechanism of “Cistanche deserticola‐Polygala” in treating AD and provide a basis for the treatment of AD with “Cistanche deserticola‐Polygala”.
Determination of heavy metal contamination and pollution indices of atmospheric dust in Dushanbe and Ayvaj, Tajikistan
Authors: Khalifaeva Shohina , Abdullaev Sabur , Maslov Vladimir , Safarov Bakhtiyor , Shukurov Firdavs
Published: October 2024

In this paper was studied the content of heavy metals in atmospheric dust of Dushanbe and Ayvaj. Dust samples were taken and analyzed to determine the content of heavy metals (HM): Zn, Pb, Cu, Cr, V, Ni, Co, As, Sr, MnO, TiO2 and Fe2O3 using X-ray fluorescence spectrometry. The pollution levels and environmental risks of HMs were assessed using the geoaccumulation index, contamination factor, pollution load index and potential ecological risk index. The results revealed severe contamination of atmospheric dust from Ayvaj and Dushanbe with particularly hazardous HMs such as As and Pb, the proportion of As is higher in the dust of Dushanbe, and the contribution of Pb is significant in the samples of Ayvaj. The concentrations of As, Pb, Zn, MnO, Sr, TiO2, V, Co in the dust of Dushanbe and As, Pb, Zn, Sr, TiO2, Cu in the dust of Ayvaj showed high variability (CV> 35%), which indicates an intense influence of anthropogenic activity. The results of the pollution factor analysis show that As, Co, V in Ayvaj atmospheric dust samples and Pb, Cr, Ni, V, MnO in Dushanbe samples were assigned to the class of very high pollution (CF>3). According to the results of the geoaccumulation index Ayvaj is heavily polluted with the following elements: V, Pb, Cr (3< Igeo ≤4). Based on the ecological risk index method, As and Pb were found to be priority pollutants in the study areas.
Investigation of atmospheric particles in Urmia Lake region using a hand-held sun-photometer
Authors: Alizadeh Salar , Bayat Ali , Khalesifard Hamid R.
Published: October 2024

Urmia Lake is a hypersaline lake in Northwest Iran. Regions inside its water catchment area experience frequent dust events. We are reporting the results of a two-year measurement campaign using a Calitoo sunphotometer, alongside synoptic measurements, satellite data, and atmospheric models. The monthly mean aerosol optical thickness (AOT) demonstrates a seasonal pattern, with fine particles prevailing in the winter and coarse particles being dominant during the summer months. Approximately 69% and 10% of the measurements indicate urban-industrial pollution and dust as the primary atmospheric particle types in the region, respectively. On the remaining days, a combination of the aforementioned aerosol types prevails as the dominant atmospheric particle composition. An in-depth analysis of a specific dust event unveiled a 24-hour delay between the peak AOT and the subsequent increase in particulate matter. Furthermore, the HYSPLIT model’s backward trajectory analysis depicted the transport of a dust plume from Mesopotamia to Urmia Lake, inducing alterations in AOT, mass concentrations, and visibility.
Recent advancements in the application of natural fibre/particulate based polymer composites in automotive industry: a review on sustainable development
Authors: Oladele Isiaka O. , Bichang’a Dennis O. , Borisade Sunday G. , Isola-Makinde Baraka A. , Akinbamiyorin Ilesanmi , Githinji David N.
Published: October 2024

The global environmental protection legislations, desire for cost-saving and weight reduction, and depleting petroleum-based raw materials have been the driving force behind the adoption of cellulosic fibres/particulates as reinforcing fillers and materials in polymer-based composites for diverse applications in these modern days. Natural fibres/particulates offer the benefits of biodegradability, sustainability, renewability, and lightweight. Therefore, it has been established that natural fibre/particulate-based polymer composites meet the environmentally friendly demands of the automotive industry. Thus, plant fibre/particulate-based polymeric composites are increasingly replacing non-biodegradable synthetic fibre/particulates-based composites and high energy-consuming products in automobile applications. This review provides an overview of cellulosic fibre/particulate-based polymeric composites in automobile body parts, the commonly used plant fibres/particulates, and their respective specific application areas in the automobile industry. The review also focused on different polymeric matrices for cellulosic fibre/particulate-based composites, the properties of the developed vegetable fibre/particulate-based composites, challenges associated with this class of engineering materials, and various strategies reported in literature for overcoming these challenges. The review showed that surface modification and treatment, hybridization, incorporation of nano-fillers, and advancement in the composite manufacturing processes are effective in addressing the identified challenges of plant fibre/particulate-based composites hindering their application in the automobile industry. Hence, the paper reviews the recent advances in the applications of plant fibre/particulate-based polymer composites in the automobile industry.
Stand, Potenzial und Barrieren der digitalen Transformation von
Frauenmilchbanken: Eine Umfrange unter AnwenderInnen
Authors: Ascherl Rudolf Georg , Berns Monika , Fusch Christoph , Karger-Seider Judith , Klotz Daniel , Naust Barbara , Sturm-Hentschel Ulrike , Gebauer Corinna ,   für die Frauenmilchbank-Initiative e.V.
Published: October 2024

Die Digitalisierung im Frauenmilchbankwesen wurde in einer Umfrage unter
Teilnehmenden des größten deutschsprachigen Fachsymposiums für Frauenmilchbanken
untersucht. Von den 100 Teilnehmenden waren 47% Pflegende, 23% ÄrztInnen und 3%
Hebammen. Die überwältigende Mehrheit (96%) wünschte sich mehr Digitalisierung
in ihrer Milchbank. Die am besten digitalisierten Prozesse waren die Befunde der
SpenderInnen, Beschriftung und Bestellung. Gleichzeitig zeigte sich eine
Diskrepanz zwischen dem maximal vorstellbaren Potenzial und der aktuellen
Umsetzung der digitalen Transformation. Die Befragung offenbarte die Vielzahl an
hauseigenen digitalen Lösungen. Als potenzielle Hauptvorteile der
Digitalisierung wurden Effizienzsteigerungen genannt, während
Implementierungsaufwand und Sicherheitsbedenken, insbesondere Stromausfall und
Cyberangriffe, nachteilig gesehen wurden. Finanzielle und personelle Engpässe,
Widerstände der lokalen EDV-Abteilung und rechtliche Bedenken wurden als größte
Barrieren wahrgenommen. Trotz dieser Herausforderungen und kritischer
Betrachtung der Nachteile betonten die Teilnehmer starken Optimismus und einen
Wunsch nach weiterer Digitalisierung im Frauenmilchbanksektor.
Denosumab for Management of Hypercalcemia in Primary
Hyperparathyroidism
Authors: Zhao Yihan , Zhang Fang , Zhang Simin , Zhang Xiaona , Gao Leili , Ren Qian , Han Xueyao , Ji Linong
Published: October 2024

Denosumab is a completely human monoclonal high-affinity antibody that binds to
the nuclear factor kappa-B ligand (RANKL) and is widely used to treat
osteoporosis. Furthermore, it can potentially lower serum calcium levels by
inhibiting osteoclast activation and preventing bone calcium from being released
into the blood. This review aimed to provide evidence of the efficacy and safety
of denosumab in treating hypercalcemia in primary hyperparathyroidism (PHPT).
PubMed and the Cochrane Library were searched for published studies that
described denosumab for hypercalcemia management in PHPT. Data were extracted by
two independent investigators and analyzed using SPSS 23. The risk of bias was
assessed by NIH Quality Assessment Tool. In total, 161 patients with PHPT from
18 studies were included in this review. The average age was 61 (47–72) years
and the highest serum calcium was 3.76 (3.11–4.20) mmol/l. We found that
denosumab can effectively reduce the serum calcium level by a median reduction
of 0.5 mmol/l within 3 days. Significant reduction was maintained for 14 days.
The serum calcium-lowering effect weakened after one month. In conclusion,
denosumab has a potential clinical value in treating hypercalcemia in patients
with PHPT.
ERN eUROGEN Guidelines on the Management of Anorectal Malformations Part I: Diagnostics
Authors: Aubert Ophelia , Irvine Willemijn F.E. , Aminoff Dalia , de Blaauw Ivo , Cascio Salvatore , Cretolle Célia , Iacobelli Barbara Daniela , Mantzios Konstantinos , Midrio Paola , Miserez Marc , Sarnacki Sabine , Schmiedeke Eberhard , Schwarzer Nicole , Sloots Cornelius , Stenström Pernilla , Lacher Martin , Gosemann Jan-Hendrik
Published: October 2024

Introduction Anorectal malformations (ARMs) are rare congenital anomalies that involve the anus, rectum, and oftentimes the genitourinary tract. The management of ARM patients is complex, and many controversies exist. To address this issue, the European Reference Network eUROGEN for rare and complex urogenital conditions aimed to develop comprehensive guidelines for the management of ARM.

Methods The Dutch Quality Standard for ARM served as the basis for the development of guidelines applicable on a European level. Literature was searched in Medline, Embase, and Cochrane. The ADAPTE method was utilized to incorporate the newest available evidence. A panel of 15 experts from 7 European countries assessed currency, acceptability, and applicability of recommendations. Recommendations from the Dutch Quality Standard were adapted, adopted, or rejected, and recommendations were formed considering current evidence and/or expert consensus.

Results Prenatal and neonatal diagnostic workup as well as postsurgical follow-up of anorectal, genitourinary tract, and neurologic system were reviewed. Seven new studies were identified. The panel adapted 13 recommendations, adopted 7, and developed 8 de novo. The availability of high-quality evidence was limited, and most recommendations were based on retrospective studies, case series, or expert opinion.

Conclusion Patients with ARM and their families require highly specialized and comprehensive care from the prenatal period to adulthood. This guideline provides recommendations for a comprehensive diagnostic workup of children with ARM throughout their life that is applicable on a European level.
An Updated Evaluation of the Management of Nerve Gaps: Autografts, Allografts, and Nerve Transfers
Authors: Johnson Anna Rose , Said Abdullah , Acevedo Jesus , Taylor Ruby , Wu Kitty , Ray Wilson Z. , Patterson J. Megan , Mackinnon Susan E.
Published: October 2024

Within the past decade, there have been multiple innovations in the field of nerve surgery. In this review, we highlight critical changes and innovations that have helped advance the field and present opportunities for further study. This includes the modification and clarification of the classification schema for nerve injuries which informs prognosis and treatment, and a refined understanding and application of electrodiagnostic studies to guide patient selection. We provide indications for operative intervention based on this nerve injury classification and propose strategies best contoured for varying injury presentations at differing time points. Lastly, we discuss new developments in surgical techniques and approaches based on these advancements.
Inflammatory Bowel Disease and Reproductive Health: A Focus on Pregnancy Planning and Outcomes
Authors: Mujumdar Sahaj , D'Souza Michelle , Abdalla Maisa I.
Published: October 2024

Reproductive counseling is crucial for women's health, especially for those with inflammatory bowel disease (IBD), which often affects younger patients during their childbearing years. Patients with IBD need special considerations when planning for pregnancy. Preconception counseling is important as it helps patients make informed decisions about pregnancy and allows for optimal management of IBD before, during, and after pregnancy. In this review, we aim to provide guidance for managing and treating patients with IBD throughout the preconception, pregnancy, and postpartum period.