bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN INFORMASI OBAT DI KLINIK UMMI HC KEDATON
Authors: Lestari Aulia Eka , Nofita Nofita , Ardiyansyah Ardiyansyah
Published: June 2023

Abstrak:ANALISIS TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN INFORMASI OBAT DI KLINIK UMMI HC KEDATON. Kepuasan pasien dalam menerima Pelayan Informasi Obat (PIO) adalah hal yang sangat penting karena kepuasan pasien yang tinggi akan menggambarkan baik buruknya PIO yang diberika. Oleh sebab itu dilakukan Analisis Tingkat Kepuasan Pasien Terhadap Pelayanan Informasi Obat di Klinik Ummi HC Kedaton bertujuan untuk mengetahui tingkat kepuasan pasien  terhadap Pelayanan  Informasi Obat yang diberikan berdasarkan lima dimensi kepuasan yaitu Reliability (Keandalan), Assurance (Jaminan), Tangible (Penampilan), Emphaty (Empati), Responsivensess (Ketanggapan). Penelitian ini merupakan jenis penelitian deskriptif  non ekperimental dengan model pendekatan Cross Sectional dengan metode yang paling terkenal untuk mengetahui kepuasan pelanggan yaitu Servqual (Service Quality). Penilaian terhadap kepuasan didapatkan dari hasil penyebaran kuesioner yang memuat 5 dimensi kepuasan. Responden dalam penelitian ini sebanyak 100 pasien yang mendapatkan obat dan menerima PIO. Hasil penelitian menunjukan bahwa tingkat kepuasan berdasarkan jenis kelamin perempuan (88,30%) dan laki-laki (83,43%), berdasarkan usia <18 tahun (96,21%), 18-25 tahun (92,46%), 26-45 tahun (89,96%), 46-65 tahun (91,48%), >65 tahun (81,81%). Berdasarkan pekerjaan swasta (90,24%), wiraswasta (89,81%), PNS (91,77%), dan lain-lain (93,01%). Berdasarkan pendidikan terakhir SMA (92,83%), D3 (88,18%), S1 (89,96%), dan lain-lain (100%). Analisis kuantitatif dengan Skala Likert menunjukan bahwa tingkat kepuasan berdasarkan dimensi Reliability (88,18%), dimensi Assurance (96,81%), dimensi Tangible  (99,68%), dimensi Emphaty (97%), dan dimensi Responsiveness (73,75%). Sehingga persentase rata-rata tingkat kepuasan pasien terhadap Pelayanan Informasi Obat (PIO) di Klinik Ummi HC Kedaton secara keseluruhan sebesar (91,08%) dengan kategori sangat puas.
NYERI KEPALA SEKUNDER ET CAUSA RHINOSINUSITIS : LAPORAN KASUS
Authors: Fitriyani Fitriyani , Andhara Kevin
Published: June 2023

Abstrak: Nyeri Kepala Sekunder ec Rhinosinusitis. Nyeri kepala adalah rasa nyeri atau rasa tidak mengenakkan pada daerah kepala dengan batas bawah dari dagu sampai kedaerah belakang kepala (area oksipital dan sebagian daerah tengkuk) Telah dilaporkan satu kasus di Rumah Sakit Pertamina Bintang Amin dengan keluhan nyeri kepala sekunder ec rhinosinusitis pada seorang perempuan  berusia 49 tahun yang ditegakkan diagnosisnya berdasarkan anamnesis didapatkan nyeri kepala dari dahi hingga leher. pemeriksaan fisik nyeri ketuk maskila dan pemeriksaan penunjang CT scan didapatkan Sinusitis maksilaris ringan kiri dan Deviasi septum nasalis ke kanan, diberikan penanganan pemberian obat dengan paracetamol.
Gambaran Tingkat Pengetahuan Remaja Putri tentang Dampak Pernikahan Dini di SMA N 4 Sungai Raya Kabupaten Kubu Raya
Authors: Sofila Sofila , Murtilita Murtilita , Fujiana Fitri
Published: June 2023

ABSTRACT The high incidence of early marriage is a problem that occurs in Indonesia today.  With the high rate of early marriage, it will have an impact on various aspects both socially, economically, family, psychologically and especially on health, one of the main health problems that occurs is that it will experience reproductive health problems, especially for women. West Kalimantan has entered the third rank with the highest rate of early marriage in Indonesia has early marriage in Indonesia has increased, especially after the pandemic, namely since 2020. To describe the level of knowledge of young women about the impact of early marriage at SMA N 4 Sungai Raya. Quantitative research using descriptive research methods, totaling 133 respondents using proportionate stratified random technique.  Data analysis used descriptive statistical analysis. The results of this study indicate that the majority of respondents at SMA N 4 Sungai Raya have sufficient knowledge, as many as 67 people (50,4%), 35 people with less knowledge (26,3%) and 31 people with good knowledge (23,3%). The level of knowledge of young women about the impact of early marriage at Sma n 4 Sungai Raya the most knowledge enough and the least knowledge well.  Keywords: Impact of Early Marriage, Early Marriage,  Knowledge  ABSTRAK Tingginya tingkat  kejadian pernikahan dini menjadi permasalahan yang terjadi di Indonesia saat ini. Dengan tingginya tingkat pernikahan dini ini akan berdampak pada berbagai macam aspek baik secara sosial, ekonomi, keluarga, psikologis dan terutama pada kesehatan, salah satu masalah kesehatan utama yang terjadi yaitu akan mengalami gangguan pada kesehatan reproduksi terutama pada wanita. Kalimantan Barat memasuki peringkat ke-3 dengan tingkat pernikahan dini tertinggi di Indonesia, dan pernikahan dini di Indonesia ini mengalami peningkatan terutama setelah terjadinya pandemi yaitu sejak tahun 2020. Mengetahui gambaran tingkat pengetahuan remaja putri tentang dampak pernikahan dini di SMA N 4 Sungai Raya. Penelitian kuantitatif dengan menggunakan metode penelitian deskriptif yang berjumlah 133 responden dengan menggunakan teknik proportionate stratified random. Analisa data menggunakan analisis statistik deskriptif. Hasil penelitian ini menunjukkan bahwa mayoritas responden SMA N 4 Sungai Raya berpengetahuan cukup sebanyak 67 orang (50,4%), berpengetahuan kurang 35 orang (26,3%) dan berpengetahuan baik 31 orang (23,3%). Tingkat pengetahuan remaja putri tentang dampak pernikahan dini di SMA N 4 Sungai Raya paling banyak berpengetahuan cukup dan paling sedikit yang berpengetahuan baik. Kata Kunci: Dampak Pernikahan Dini, Pernikahan Dini, Pengetahuan
Torrefaction: Process Parameters and Reactor Design
Authors: Djurdjevic Milica , Papuga Sasa
Published: June 2023

Torrefaction is a thermochemical process, where biomass is obtained in temperature range from from 200 to 300 °C, in inert atmosphere with the aim to increase carbon content of biomass. In this paper, emphasis is on biomass feedstock types, different effects on torrefaction success, and torrefaction reactors.
TWENTY-TWO YEARS OF SCIENCE COMMUNICATION RESEARCH: A BIBLIOMETRIC ANALYSIS
Authors: Balcı Emre Vadi , Duğan Özlem , Cavas Bulent
Published: June 2023

In recent years, the number of academic studies in the field of science communication has increased. It is important to make a general examination of the studies on science communication and to reveal their distribution according to years and countries in order to draw the framework of science communication studies. The main aim of this study was to analyze the science communication-based articles published in journals in the Web of Science (WoS) index in the last 22 years. Within the scope of the study, articles were scanned by typing keywords such as "topic", "title", "keywords" science communication from the WoS database and 322 articles were examined by bibliometric analysis method. As a result of the study, the articles published between 2000 and 2022 were examined according to years, countries, funding organizations, research area, publishing houses, country scores and citations. According to the results, most articles were published in 2022(N = 58); USA, UK, Australia, Germany ranked first with the number of articles and SAGE (N = 74) ranked first in publisher distributions. This study offers a global perspective on science communication and proposes a vision for future research.
Keywords: Bibliometrics analysis, journal articles, research trends, science communication, Web of Science (WoS)
GAMIFIED EDUCATIONAL ROBOTS LEAD AN INCREASE IN MOTIVATION AND CREATIVITY IN STEM EDUCATION
Authors: Chen Tan-I , Lin Shih-Kai , Chung Hung-Chang
Published: June 2023

The combination of education and robots is becoming an increasingly important issue. Although researchers have conducted some studies on educational robotics in STEM education at the undergraduate level, no research examined the effects of gamified educational robotics on participants’ motivation and creativity. Therefore, this study examines the effects of gamified educational robots on participants’ learning motivation and creativity in STEM. A quasi-experimental research design was used in this study. A total of 108 students from two classes enrolled in the information technology course were involved as participants. Learning motivation and creativity scales were used to collect data. The participants were introduced to a gamified educational robot as the course objective, learning content, and game mechanism to increase motivation and help students solve problems. In contrast, students in the control group received conventional instruction consisting of group discussions and lectures. Activities in both groups were held for eighteen weeks in three phases. The results showed that gamified educational robots could enhance learning motivation and positively influence learners' creativity. The results also indicate that learning motivation has significant effects on creativity, and students with high motivation perform better in terms of creativity. The results strengthen interdisciplinary STEM teaching and promote students' learning outcomes.
Keywords: gamification in STEM education, educational robot, STEM curriculum, learning motivation
TYPES OF QUALITY AND EQUAL SCIENCE EDUCATION SYSTEMS AND THE DEVELOPMENT OF EQUALITY IN EDUCATION
Authors: Jiang Tao , Jin Hong-wei , Ma Wen-jie , Chen Ji-gen , Yuan Ling-min
Published: June 2023

Some education systems have both quality and equality. They have achieved educational equity. This study aimed to uncover the practical wisdom of such systems in developing educational equality. A quantitative research design was used. Family capital and science achievement were the variables analyzed. They were secondary data collected by the 2018 PISA test. PISA surveyed students' family capital with questionnaires and measured students' science achievement with cognitive items. Six education systems with quality but low equality comprised the control group. Its sample size ranged from 4656 to 8312. The experiment group included nine quality and equal education systems, with sample sizes ranging from 3766 to 21490. The relative error and conditional probability were calculated to determine educational equality. Rawls' difference principle was used as a theoretical perspective. The findings showed that quality and equal education systems had three types: equal-start, equal-improvement, and egalitarian. The primary measure to improve equality in education is to ensure educational benefits for students in the bottom quartile of family capital. The development of educational equality was accompanied by a sustained reduction in the achievement gap between the disadvantaged and the advantaged. Implications for educational practice are discussed.
Keywords: disadvantaged students, educational equity, equality in education, inequality in education, science education
ONE HUNDRED CORE CONCEPTS IN CHEMISTRY AND UPPER-SECONDARY SCHOOL TEACHERS’ AND STUDENTS’ CHEMISTRY CONCEPTUAL STRUCTURES
Authors: Qian Yangyi , Wang Yangqian , Wen Jinju , Wu Simin , Zhang Jijia
Published: June 2023

A solid grasp of basic concepts and their relationships can stimulate learning motivation, improve teaching quality, and help students to build a body of knowledge in a discipline. Most of the previous studies have considered one chemistry topic amongst many others. To date, no studies have been conducted to explore the conceptual structures of teachers and students based on chemical concepts. Experts, teachers, and students (N=2348) from three public universities and ten upper-secondary schools in China participated in the studies. In Study 1, personal interviews, material evaluation, and importance rating questionnaires were conducted to determine the core concepts. In Study 2, the multidimensional scaling (MDS) and cluster analysis (CA) were conducted to explore the conceptual structures of upper-secondary school teachers and students. Then the structural differences between high- and low-achieving students were compared. The results showed that the three-dimensional solutions were appropriate for the conceptual structures of teachers and students, respectively. The high-achieving students have a more scientific and organized conceptual structure than those of low-achieving students. This study is the first to explore core concepts and their structure with a large sample size, and the reliable results help students understand abstract chemical concepts and improve their interest in scientific disciplines in the future.
Keywords: conceptual structure, core concepts in chemistry, multidimensional scaling, cluster analysis, upper-secondary school students
SIMULATION-BASED AND VIDEO-BASED APPROACHES TO DIVERSIFYING PHYSICS HOMEWORK
Authors: Simić Bojana , Mešić Vanes , Đapo Nermin , Movre Šapić Iva , Vidak Andrej , Alić Amina , Erceg Nataša
Published: June 2023

Physics homework often boils down to solving end-of-chapter quantitative problems. For targeting different learning goals of physics education, different types of homework are needed. The aim of this research was to compare the effectiveness of simulation-based, video-based, and paper-and-pencil homework in developing an understanding about Newton’s laws and forming positive attitudes towards physics homework. 150 first-year students from the Faculty of Chemical Engineering and Technology at the University of Zagreb (Croatia) were randomly assigned to one of the three above-mentioned homework approaches. After, students had lectures and seminars on Newton’s laws, they were administered a pre-test. In the next three weeks, the students completed three homework assignments on Newton’s laws, after which they completed a post-test. For students from all three homework approaches a substantial improvement in conceptual understanding has been observed. Although the three approaches proved to be equally effective when it comes to developing understanding, the simulation-based approach was found to be superior when it comes to developing positive attitudes towards physics homework. If one controls for target knowledge, the modality of the homework assignment does not affect cognitive outcomes, but it does affect students’ attitudes towards homework.
Keywords: conceptual understanding, experimental study, simulation-based homework, video-based homework
PECULIARITIES OF FORMATION AND FUNCTIONING OF CREATIVITY AS A LINGUISTIC PHENOMENON
Authors:   Donetsk National University of Economics and Trade named after Mykhailo Tugan-Baranovsky, Zinchenko V. M. , Boiko V. M. ,   Donetsk National University of Economics and Trade named after Mykhailo Tugan-Baranovsky
Published: June 2023

Objective. The objective of the research is to establish patterns, factors of influence and cause and effect in the processes of formation and realization of creativity, linguistics in particular. Methods. The authors apply the following scientific methods: theoretical — analysis and synthesis, analogy and thought experiment, practical — analysis of scientific literature, on the basis of which conclusions based on the laws, factors of influence and cause and effect in the processes of formation and realization of creativity, linguistic in particular. Results. Creativity is an important characteristic of the modern world, the «driving force» of progress. It implies a tendency to perceive a particular issue from a different angle, with a departure from the traditional norms of worldview. Creativity is seen as the ability to realize creativity. The factors of formation of the phenomenon of creativity are the factors of the system «4 P»: creative personality, creative process, creative press, creative product. Creativity as a creative activity is divided into several stages: perception of the problem, finding a solution, the emergence and formulation of hypotheses, testing the hypotheses, modifying them and obtaining the result. The level of creativity depends largely on the type of dominant intelligence in the individual. The linguistic kind of intelligence, including linguistic, foreign-language, literary and oratorical subspecies, determines the level of development of creative-linguistic abilities. Linguistic talent is an element of linguistic creativity. This category is defined as the synthesis of linguistic abilities, motivation and auxiliary factors for the development of talent. Linguistic creativity is realized through the formation of communicative strategies, the content of which takes into account the originality, effectiveness and social acceptability of material presentation. Therefore, linguistic creativity is an important subspecies of creativity that is pervasive throughout the world.
Filega/In Search: Embodying Community in Ethiopia
Authors: Wilcox Hui Niu , Belay Melaku
Published: June 2023

This paper offers a decolonial reading of Filega, an annual grassroots street performance organized by Ethiopian dance artist Melaku Belay in the context of an Orthodox Christian religious festival Timket. Our contextualized reading illuminates Ethiopian artists’ capacity to create beauty, joy and community; they do so by disrupting the dichotomies between discipline and freedom, the sacred and the profane. Filega’s decolonial significance also lies in its potential to transform public spaces and collective memories in service of community. In constructing this paper, we seek to decolonize our writing practice by unsettling the theory/practice dichotomy, and by experimenting with modes of co-authorship. Along with Filega participants and witnesses, we search for decolonized understandings of self, community, and discipline.
Is Tranexamic Acid an Effective Prevention in the Formation of Epidural Fibrosis? Histological Evaluation in the Rats
Authors: Circi Esra , Atici Yunus , Baris Alican , Senel Ahmet , Leblebici Cem , Tekin Saltuk Bugra , Ozturkmen Yusuf
Published: June 2023

Objective : The present study aimed to determine the topical and systemic efficacy of tranexamic acid (TXA) on epidural fibrosis in a rat laminectomy model.Methods : Thirty-two 12-month-old adult Sprague-Dawley rats were used in this study. Each rat underwent bilateral laminectomy at the L1 and L2 vertebral levels. Rats were divided into four groups : in group I (control group, n=8), a laminectomy was performed and saline solution was applied into the surgical space. In group II (topical group, n=8), laminectomy was performed and 30 mg/ kg TXA was applied to the surgical site before skin closure. In group III (systemic group, n=8), 30 mg/kg TXA was administered intravenously via the tail vein in the same session as the surgical procedure. In group IV (topical and systemic group, n=8), TXA was administered 30 mg/kg both topical and intravenous. The rats were sacrificed at 4 weeks postoperatively. Masson’s trichrome and hematoxylin and eosin were used to assess acute inflammatory cells, chronic inflammatory cells, vascular proliferation, and epidural fibrosis.Results : Epidural fibrosis, acute inflammation, chronic inflammation, and sum histologic score value were significantly lower in the systemic TXA group, systemic and topical TXA groups than in the control group (p<0.05). In addion, the sum histologic score was significantly lower in the topical TXA group than in the control group (p<0.05).Conclusion : In this study, epidural fibrosis formation was prevented more by systemic application, but the topical application was found to be effective when compared to the control group. As a result, we recommend the systemic and topical use of TXA to prevent epidural fibrosis during spinal surgery.
Clinical and Genetic Findings in Korean Patients with Choroideremia
Authors: Jo Woo Gyeong , Lee Christopher Seungkyu , Han Jinu
Published: June 2023

Purpose: We share and analyze the clinical presentations and genotypes of Korean male patients and female carriers who visited our clinic.Methods: Six male patients and three female carriers with comprehensive ophthalmic examinations and next-generation sequencing were included. Detailed clinical features were identified using visual field (VF) test and multimodal imaging including color fundus photography, fundus autofluorescence (FAF), and optical coherence tomography (OCT).Results: Six male patients were diagnosed with choroideremia at the median age of 25 years. Before genetic testing, three patients (50.0%) were clinically diagnosed with choroideremia, while the other three patients (50.0%) with retinitis pigmentosa. Patients showed different types of hemizygous CHM variants, including two nonsense variants, c.715C>T:p.(Arg239*) and c.799C>T:p.(Arg267*); two frameshift variants, c.1584_1587del:p.(Val529Hisfs*7) and c.403_404del:p.(Asp135Phefs*9); one splicing variant c.1511-28_1511-2del; and one exon 2-8 duplication. The latter three variants were novel. Two female carriers had heterozygous exon 2-8 duplication and the other one female carrier had heterozygous nonsense variant c.715C>T:p. (Arg239*). Fundus showed diffuse yellow-whitish scleral reflex and granular pigmented lesions. FAF showed multiple patchy hypofluorescence lesions, sparing macula. OCT showed thinning of outer nuclear layer, ellipsoid zone, retinal pigment epithelium layer, choroid thickness, interlaminar bridges, outer retinal tubulations, and microcysts in the inner nuclear layer. VF showed ring scotoma pattern with small amount of remaining central field. Asymptomatic female carriers showed variable fundus findings and mild changes in OCT.Conclusions: A detailed description of the genotypes with three novel mutations and phenotypes of six choroideremia patients and three CHM mutation female carriers are presented.
Mini-Review: Clinical Features and Management of Granular Corneal Dystrophy Type 2
Authors: Chang Myung Soo , Jun Ikhyun , Kim Eung Kweon
Published: June 2023

Granular corneal dystrophy type 2 (GCD2) is an autosomal dominant corneal stromal dystrophy that is caused by p.Arg124His mutation of transforming growth factor β induced (TGFBI) gene. It is characterized by well demarcated granular shaped opacities in central anterior stroma and as the disease progresses, extrusion of the deposits results in ocular pain due to corneal epithelial erosion. Also, diffuse corneal haze which appears late, causes decrease in visual acuity. The prevalence of GCD2 is high in East Asia including Korea. Homozygous patients show a severe phenotype from an early age, and the heterozygote phenotype varies among patients, depending on several types of compound heterozygous TGFBI mutations. In the initial stage, conservative treatments such as artificial tears, antibiotic eye drops, and bandage contact lenses are used to treat corneal erosion. Different surgical methods are used depending on the depth and extent of the stromal deposits. Phototherapeutic keratectomy removes anterior opacities and is advantageous in terms of its applicability and repeatability. For deeper lesions, deep anterior lamellar keratoplasty can be used as the endothelial layer is not always affected. Recurrence following these treatments are reported within a wide range of rates in different studies due to varying definition of recurrence and follow-up period. In patients who have undergone corneal laser vision-correction surgeries such as photorefractive keratectomy, LASEK, or LASIK including SMILE surgery, corneal opacity exacerbates rapidly with severe deterioration of visual acuity. Further investigations on new treatments of GCD2 are necessary.
Exploring Communication Management and Public Relations in Two Emerging Markets, China and Thailand
Authors: Siba Borah Prasad , Korankye Benard , Gaye Tijan , Afotey Odai Leslie , Komugisa Jill Ivy
Published: June 2023

This study aimed to address the lack of empirical research in public relations management by investigating the perspectives of professional leaders in public relations in two emerging markets, namely China and Thailand. To gather information, a pragmatic mixed-method approach, which included a survey and interviews, was employed. The data was then processed using SPSS using a sample size of 234. The study developed a framework based on the Meng and Berger Model on PR leaders. It explores how leadership in public relations is shaped by the sociopolitical context of the nation by examining and comparing the cases of China and Thailand. The study draws on the interpretation of professional leadership in public communication by PR leaders. The participants from both countries indicated that there were some similarities and differences between the Chinese and Thai markets concerning public relation leadership. With the most important issue raised in both countries, speed and volume of information appeared to be the most important. In addressing the issues, in-service training to gain new skills and taking advantage of the internet to acquire information appeared as the most important tools. Inspiring and motivating, and ability to manage teams appeared as important leadership abilities considered of value in both countries. The study identified three key dimensions that were present in both countries, namely team collaboration, communication knowledge management, and organizational culture and structure.
Administrative Challenges of Centre Workers of University of Education, Winneba
Authors: Subbey Michael
Published: June 2023

This study examined the administrative challenges faced by study centre workers of the University of Education, Winneba. The study employed a cross-sectional survey design. A structured questionnaire was administered to 84 study centre workers, selected through census. Frequencies, percentages, means and standard deviation, were used to analyse the data obtained. The study revealed that centre workers admitted to knowing and taking up their administrative responsibilities for the programme’s success. Again, the study showed that irregular payment of tutors’ claims and insufficient and unequal distribution of course materials were challenges faced by the study centre workers. Also, the centre workers employed some coping skills to run the study centres. These include: arriving on time during tutorial and examination days to put arrangements in place; delegation of authority to course representatives to execute daily routines; making available teaching and learning resources to tutors. The study recommends that the management of CODeL, UEW, should organise frequent workshops for the Centre workers to update their knowledge about their responsibilities. In addition, management should resolve the issue of irregular payment of tutors' claims and sensitize the workers on a regular basis regarding strategies they could employ to address their challenges in their administrative duties.
Distrito Pegmatítico de Santa Maria de Itabira (Minas Gerais) e seus depósitos de minerais de berílio
Authors: Dias Coralie Heinis , Chaves Mario Luiz de Sá Carneiro
Published: June 2023

A Província Pegmatítica Oriental do Brasil (PPOB) constitui uma extensa região situada na maior parte a leste do estado de Minas Gerais, onde ocorrem rochas graníticas com pegmatitos associados, muitas vezes representando importantes depósitos minerais. Esta província envolve distritos pegmatíticos com características peculiares em termos geográficos e geotectônicos. Dentre eles, o Distrito de Santa Maria de Itabira é mais meridional, sendo geologicamente pouco conhecido; seu interesse econômico é voltado principalmente para minerais de berílio, como berilo (água-marinha e esmeralda) e crisoberilo (alexandrita). O presente trabalho objetiva a descrição e a caracterização das principais áreas mineralizadas desse distrito, a partir da bibliografia disponível e de novos dados geológicos. Os depósitos são divididos em três campos pegmatíticos designados Itabira–Nova Era, Santa Maria de Itabira–Hematita e Ferros–Esmeraldas de Ferros. O primeiro constitui uma faixa principalmente esmeraldífera de grande potencial econômico, cujos depósitos mais importantes são os de Belmont, Piteiras e Capoeirana. O segundo campo pegmatítico (Santa Maria de Itabira–Hematita) apresenta pegmatitos de importância econômica para a produção de água-marinha, destacando-se os depósitos Ponte da Raiz, Morro Escuro, Jatobá e Tatu, nas imediações de Santa Maria de Itabira, além de pegmatitos produtores de alexandrita, no município de Antônio Dias. O terceiro campo (Ferros–Esmeraldas de Ferros) possui na atualidade poucas atividades minerárias, embora já tenha produzido cristais gigantes de topázio, além de ter sido o local de descoberta de esmeraldas em Minas Gerais. Os resultados obtidos apontam para as peculiaridades mineralógicas deste distrito em relação aos demais da PPOB.
The Nobel Prize in Physiology 1977: A literature review of the Radioimmunoassay Technique
Authors: Carvalho Matheus dos Santos do Nascimento , Costa Adriano Santana de Luna , Santana Allan Vieira Almeida , Batista Rodrigo Santana de Luna , Mesquita Neto Fernando Pinto de , Lima Jefferson Cavalcante de , Cabral Adriane Borges
Published: June 2023

The first study about radioimmunoassay was published in 1960 by 2 scientists, who created this new method to quantify human insulin, at a time when studies on diabetes and its pathophysiology were beginning to stand out. Years later, due to its strong relevance to the scientific world, such work was awarded the Nobel Prize in Physiology in 1977. Thus, the present study aims to expose the historical context of the discovery, the initial studies on diseases whose immunological origin was still unknown, the beginning of radioimmunoassay techniques and their potential benefits and effects for science. Therefore, a narrative review of the literature was carried out using the PubMed, Scielo and Google Scholar databases in order to find the theoretical bases that underlie the objective of the present study. The study revealed that through the use of radioisotopes for insulin labeling and the use of antibodies from animals, it was possible to quantify hormones at low blood concentrations, based on the graphic of the proportion between free marked insulin and insulin combined with antibodies. Such discovery was important to understand the pathophysiology of many diseases, although on the other hand it presents its risks because it involves radioactive material and because it is now in disuse due to the creation of methods such as ELISA. It is concluded that due to the historical and scientific importance of the RIA, this method proved to be worthy of the most renowned scientific award in the world.
Aleitamento materno em crianças portadoras de fenda labiopalatina: Revisão integrativa
Authors: Santos Hyasmym Kaiane Faesser , Moraes Suellen da Rocha Lage , Marques Ana Karolina de Oliveira
Published: June 2023

Objetivo: é identificar na literatura quais fatores associados à adesão ao aleitamento materno exclusivo em lactantes de 0-6 meses de vida com fissura de lábio e/ou palato. Método: revisão integrativa. A busca foi realizada através da Biblioteca Virtual de Saúde, nas bases de Literatura Latina Americana e do Caribe em Ciências em Saúde (LILACS), Medical Literature Analysis and Retrieval System Online (MedLine) e Base de Dados em Enfermagem (BDENf). A seleção dos artigos foi realizada através da plataforma Rayyan no período de dezembro de 2022 à janeiro 2023. Resultados: Foi identificado através dos artigos, que após os genitores receberem as devidas orientações e o treinamento quanto ao uso de algumas técnicas como educação alimentar no pré-natal, perinatal e pós-natal, o uso de obturador palatino, placa de alimentação, protetor de mamilo, mamadeira especial e colher foi evidenciaram como fatores contribuintes para o sucesso da amamentação. Conclusão: poucos lactantes foram amamentados exclusivamente e por período conforme recomendado pela OMS. Identificado que o recebimento de orientações por profissionais de saúde no pré-natal, perinatal e pós-natal é de extrema importância e instigou de forma favorável, ou seja, o sucesso dessa prática está relacionado diretamente à complexidade da fissura, fator não modificável, mas, também, ao recebimento de orientações indicando ser este um espaço de intervenção a ser explorado. Comprovando também, que com as técnicas e equipamentos adequados é possível o sucesso da prática do aleitamento materno exclusivo em crianças portadoras de fenda lábio e/ou palato.
Aspectos nutricionais no manejo do Diabetes mellitus gestacional
Authors: Raimundo Yasmin Rossini , Alcantara Giuliana Paixão de Oliveira , Garcia Paloma Popov Custódio
Published: June 2023

A Diabetes mellitus se caracteriza como uma patologia que pode ser encontrada principalmente em três diferentes tipos, e dentre estes está a diabetes mellitus gestacional (DMG). O DMG se desenvolve durante a gestação, a partir da resistência insulínica e apresenta alguns fatores de risco para seu desenvolvimento, como a obesidade e sobrepeso, histórico familiar e idade materna avançada. Assim, torna-se como objetivo a compreensão da sua patologia e a ação da nutrição no tratamento e prevenção, a partir da leitura de artigos e realização da revisão de literatura integrativa. Se apresentam como riscos que esse tipo de diabetes pode gerar à saúde da mãe e do concepto a pré-eclâmpsia, predisposição para desenvolvimento de diabetes mellitus tipo 2, macrossomia e maiores riscos de obesidade. A partir da compreensão desses pontos, entende-se o acompanhamento nutricional como eficaz na prevenção e tratamento do diabetes gestacional. A dieta de baixo índice glicêmico, DASH e dieta mediterrânea mostram-se eficientes no controle glicêmico durante a diabetes gestacional e também atuam na prevenção dessa patologia, de forma a promoverem gestações sem maiores intercorrências e hábitos alimentares mais saudáveis.
Applications of genomic research in pediatric endocrine diseases
Authors: Kim Ja Hye , Choi Jin-Ho
Published: June 2023

Recent advances in molecular genetics have advanced our understanding of the molecular mechanisms involved in pediatric endocrine disorders and now play a major role in mainstream medical practice. The spectrum of endocrine genetic disorders has 2 extremes: Mendelian and polygenic. Mendelian or monogenic diseases are caused by rare variants of a single gene, each of which exerts a strong effect on disease risk. Polygenic diseases or common traits are caused by the combined effects of multiple genetic variants in conjunction with environmental and lifestyle factors. Testing for a single gene is preferable if the disease is phenotypically and/or geneically homogeneous. Next-generation sequencing (NGS) can be applied to phenotypically and genetically heterogeneous conditions. Genome-wide association studies (GWASs) have examined genetic variants across the entire genome in a large number of individuals who have been matched for population ancestry and assessed for a disease or trait of interest. Common endocrine diseases or traits, such as type 2 diabetes mellitus, obesity, height, and pubertal timing, result from the combined effects of multiple variants in various genes that are frequently found in the general population, each of which contributes a small individual effect. Isolated founder mutations can result from a true founder effect or an extreme reduction in population size. Studies of founder mutations offer powerful advantages for efficiently localizing the genes that underlie Mendelian disorders. The Korean population has settled in the Korean peninsula for thousands of years, and several recurrent mutations have been identified as founder mutations. The application of molecular technology has increased our understanding of endocrine diseases, which have impacted on the practice of pediatric endocrinology related to diagnosis and genetic counseling. This review focuses on the application of genomic research to pediatric endocrine diseases using GWASs and NGS technology for diagnosis and treatment.
Natural course of IgE-mediated food allergy in children
Authors: Jeong Kyunguk , Lee Sooyoung
Published: June 2023

The prevalence of food allergy and food-induced anaphylaxis in children is increasing worldwide. Cow’s milk, hen’s eggs, and wheat allergies in young children have a more favorable prognosis with a relatively early outgrow, while allergies to peanuts, tree nuts, and seafood are more likely to be persistent. Although our understanding of the mechanism underlying the resolution of food allergy is incomplete, the roles of dendritic cells, regulatory T cells, and regulatory B cells are important. Many past studies on the natural course of food allergy were retrospective analyses of specific study groups, but large-scale population-based prospective studies are now being published. This review summarizes recent studies of the natural course of cow’s milk, hen’s eggs, wheat, peanuts, tree nuts, soy, sesame, and seafood allergies. The potential factors affecting the natural course of food allergy include symptom severity on ingestion, age at diagnosis, allergic comorbidities, skin prick test reaction size or serum food-specific immunoglobulin (Ig) E levels, changes in sensitization degree, IgE epitope specificity, ratio of food-specific IgE to IgG4, food-specific IgA levels, component-resolved diagnostic profile, diet, gut microbiome, and interventions such as immunotherapy. Since food allergy places a significant burden on patients and their caregivers in daily life, clinicians should be able to provide relevant knowledge on the natural course of food allergy, appropriately evaluate its resolution, and offer therapeutic options whenever possible.
Systemic autoinflammatory disorders
Authors: Jeong Dae Chul
Published: June 2023

Inflammation is a physiologic defense mechanism against an out-side attack. Usually, it resolves after the removal of noxious causes, but systemic autoinflammatory disorders (SAIDs) have recurrent or repeated acute inflammation through uncontrolled gene function, which can present as gain-of-function or loss-of-function of a gene during inflammation. Most SAIDs are hereditary autoinflammatory diseases and develop by dysregulation of innate immunity through various pathways including inflammasomes, endoplasmic reticulum stress, nuclear factor-κB dysregulation, and interferon production. The clinical manifestations include periodic fever with various skin findings such as neutrophilic urticarial dermatosis, or vasculitic lesions. Some SAID cases stem from immunodeficiency or allergic reactions related to monogenic mutation. The diagnosis of SAIDs is based on clinical findings of systemic inflammation and genetic confirmation, and have to exclude infections or malignancies. Moreover, a genetic study is essential for clinical features to be suspect SAID with or without a family history. Treatment is based on understanding the immunopathology of SAID, and targeted therapy to control disease flares, reduce recurrent acute phases and prevent serious complications. Diagnosing and treating SAID requires understanding its comprehensive clinical features and pathogenesis related to genetic mutation.
X-linked hypophosphatemic rickets: from diagnosis to management
Authors: Park Eujin , Kang Hee Gyung
Published: June 2023

X-linked hypophosphatemia (XLH), the most common cause of hypophosphatemic rickets, affects one in every 20,000 people. Although conventional therapy for XLH was introduced approximately 4 decades ago, the temporary replacement of oral phosphate salts and activated vitamin D cannot completely control chronic hypophosphatemia, leaving patients with incomplete healing and residual skeletal deformity as well as at risk of endocrine abnormalities and adverse drug reactions. However, understanding the pathophysiology has led to the development of a targeted therapy, burosumab, a fibroblast growth factor-23 inhibitor that was recently approved in Korea for the treatment of XLH. This review provides insight into the diagnosis, evaluation, treatment, and recommended follow-up for a typical case of XLH and reviews its pathophysiology.
Timing of parenteral nutrition initiation in critically ill children: a randomized clinical trial
Authors: Saleh Nagwan Y. , Aboelghar Hesham M. , Abdelaty Nehad B. , Garib Mohamed I. , Mahmoud Asmaa A.
Published: June 2023

Background: The optimal timing of parenteral nutrition (PN) initiation in critically ill children remains controversial.Purpose: To identify the optimal timing of PN initiation in critically ill children.Methods: This randomized clinical trial was conducted in the pediatric intensive care unit (PICU) of Menoufia University Hospital. A total of 140 patients were randomized to receive early or late PN. The early PN group consisted of 71 well-nourished and malnourished patients who received PN on the first day of PICU admission. Malnourished (42%) and well-nourished children randomized to the late PN group (42%) started PN on the fourth versus seventh day after admission, respectively. Mechanical ventilation (MV) was the primary outcome, while PICU length of stay and mortality were secondary outcomes.Results: Patients who received early PN started enteral feeding significantly earlier (median, 6 days; interquartile range, 2–20 days) than those not provided early PN (median, 12 days; interquartile range, 3–30 days; P<0.001) and had a significantly lower risk of feeding intolerance (5.6% vs.18.8%, P=0.035). The median time required to obtain full calories enterally was shorter in the early versus late PN group (P=0.004). Furthermore, patients in the early versus late PN group had a significantly shorter median PICU stay (P<0.001) and were less likely to require MV (P=0.018).Conclusion: Patients who received early PN had a lower MV need and duration than those who received later PN and had more favorable clinical outcomes in terms of morbidity.
Neonatal family-centered care: evidence and practice models
Authors: Lee Juyoung
Published: June 2023

Although advances in neonatology have reduced the mortality rate of high-risk infants, sick newborns or pre-mature infants undergo more intensive monitoring, pain-ful procedures, and lengthy hospitalization, leading to pro-longed separation from their parents. In recent decades, the importance of parent-infant closeness early in life has become more apparent, especially in preterm infants who are prone to neurodevelopmental deficits. There is an increasing body of evidence regarding the benefits of family-centered care (FCC) in neonatal intensive care units. Key aspects related to neonatal FCC include the parents’ presence in the ward and their participation in infants’ daily care and decision-making processes. In addition, an environment that supports a private and comfortable space for each family member and infant, such as a single-family room, should be provided. To successfully implement FCC in neonatal intensive care units, the culture of care and hospital policies should be changed to successfully implement FCC in neonatal intensive care units, and appropriate training for medical staff is also required.
The concept of diagnostics and treatment of hereditary angioedema (based on international and national recommendations)
Authors:   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai, Vasilyeva M.M.
Published: June 2023

The article analyzes recommendations for the diagnosis and treatment of hereditary angioedema (HAE) issued in the United States of America, Canada, the European Union and Russia. Based on these recommendations, a tactic for managing patients with hereditary angioedema has been developed
Aggregation dynamics of tropical tunas around drifting floating objects based on large-scale echo-sounder data
Authors: Navarro-García M , Precioso D , Gavira-O’Neill K , Torres-Barrán A , Gordo Gómez D , Gallego V , Gómez-Ullate D
Published: June 2023

Based on data gathered by echo-sounder buoys attached to drifting fish-aggregating devices (dFADs) across tropical oceans, we applied a machine learning protocol to examine the temporal trends of tuna-school associations with drifting objects both in comparison to previous studies, and in the context of the ‘ecological trap’ theory. Using a binary output, metrics typically used in the literature were adapted to account for the fact that the entire tuna aggregation under the dFAD was considered. The median time it took tuna to colonize the dFADs for the first time varied between 25 and 43 d, depending on the ocean, and the longest soak and colonization times were registered in the Pacific Ocean. The continuous residence times of tuna schools were generally shorter than continuous absence times (median values: 5-7 and 9-11 d, respectively), in line with the results found by previous studies. Using a regression output, 2 novel metrics, namely aggregation time and disaggregation time, were estimated to obtain further insight into the symmetry of the aggregation process. Across all oceans, the time it took for tuna aggregations to depart from individual dFADs was not significantly longer than the time it took for the aggregations to form. This does not align with what would be expected if the association were ‘strong and long-lasting’ as proposed by one of the aspects of the ‘ecological trap’ theory. The value of these results in the context of the reasons driving the aggregation process is discussed, and further analyses to enrich and make use of this data source are proposed.
Demography across latitudinal and elevational gradients for range-expanding whelks
Authors: Waite HR , Beshai RA , Sorte CJB
Published: June 2023

Marine species worldwide are responding to ocean warming by shifting their ranges to new latitudes and, for intertidal species, elevations. Demographic traits can vary across populations spanning latitudinal and elevational ranges, with impacts on population growth. Understanding how demography varies across gradients from range center to edge could help us predict future shifts, species assemblages, and extinction risks. We investigated demographic traits for 2 range-expanding whelk species: Acanthinucella spirata and Mexacanthina lugubris. We measured reproductive output across environmental (latitudinal and shore elevation) gradients along the coast of California, USA. We also conducted intensive measurements of offspring condition (survival and thermal tolerance) across shore elevation for M. lugubris at one site. We found no difference in reproductive output, body size, or larval survival across shore heights for M. lugubris, suggesting that egg-laying behavior buffers developing stages from the relatively high level of thermal variation experienced due to daily tidal emersion. However, across latitudes, reproductive output increased toward the leading range edge for A. spirata, and body size increased for both species. Increased vital rates at the leading range edge could increase whelk population growth and expansion, allowing species to persist under climate change even if contractions occur at trailing edges.
İş Güvenliği Uzmanlarının İş Tatmin Düzeyini Etkileyen Bireysel Faktörlerin İncelenmesi: Karaman ve Konya Örneği
Authors: TOYOĞLU Ayşe Ece , ÖZER Kubilay
Published: June 2023

İş sağlığı ve güvenliği kültürünün çalışanlar ve işverenler tarafından benimsenmiş olması büyük bir öneme sahiptir. İşletmelerde iş sağlığı ve güvenliğine yönelik uygulamaların tam olarak yerine getirilmesi gerekmektedir. Bu uygulamalar üzerinde en önemli rolü üstlenen iş güvenliği uzmanıdır. Bu bağlamda iş güvenliği uzmanının işini etkin ve verimli bir şekilde yapabilmesi için iş tatmininin sağlanmış olması gerekmektedir. Çalışmada iş güvenliği uzmanlarının iş tatmini üzerinde etkisi bulunan bireysel faktörlerin belirlenmesi amaçlanmıştır. Araştırma kapsamında Konya ve Karaman illerinde, Çalışma ve Sosyal Güvenlik Bakanlığı’nda kaydı bulunan A sınıfı, B sınıfı ve C sınıfı 310 iş güvenliği uzmanına Minnesota İş Tatmin Ölçeği kısa formu ile Google docs aracılığı ile ulaşılmıştır. Verilerin istatiksel analizi için SPSS paket programı kullanılmıştır. Araştırmada iş güvenliği uzmanlarının iş tatmin düzeyi x̄=3,12 orta düzeyde bulunmuştur. İstatistiki analizlerde iş tatmininin yaş, medeni durum, cinsiyet ve eğitim durumu değişkenlerinde farklılaşmadığı; ücret ve kıdem değişkenlerinde farklılaştığı belirlenmiştir. Yüksek ücret alanlar ile kıdemi fazla olanların iş tatmin düzeyi diğer gruplardan yüksek bulunmuştur.