bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of an affect, sensation seeking, and premeditation on risky decision-making: Conditional process analysis
Authors: Verma Adarsh K. , Chivukula Usha
Published: February 2023

Risks often accompany available choices in decision-making, particularly where the monetary factor gets involved. Researchers have explored the pathways underlying risky decision-making for decades, but most of these pathways have explored the factors individually rather than through a holistic approach. The present study examines the role of personality, cognitive, and biological components in risky decision-making. Here, the Iowa Gambling Task (IGT) paradigm is used to study the targeted outcome variable (IGT payoff) in 281 healthy students. Two moderation-mediation models hypothesized sensation seeking and lack of premeditation as predictors of IGT payoff. Positive and negative moods prior to IGT administration were considered mediators, and age and gender as moderators in predicting payoff. The hypothesized models were tested using conditional process analysis. Results indicate that both predictors significantly negatively predict payoff while moderated by gender and age categories. Interestingly, the indirect relationships apply to 21–34 years old men and 21–25 years old women. These age and gender-specific findings in apparently healthy participants highlight the need for replicating the current research in different age groups and clinical populations involving maladaptive decision-making patterns.
Dietary practices, physical activity and social determinants of non-communicable diseases in Nepal: A systemic analysis
Authors: Sharma Sudesh , Matheson Anna , Lambrick Danielle , Faulkner James , Lounsbury David W. , Vaidya Abhinav , Page Rachel
Published: February 2023

Unhealthy dietary habits and physical inactivity are major risk factors of non-communicable diseases (NCDs) globally. The objective of this paper was to describe the role of dietary practices and physical activity in the interaction of the social determinants of NCDs in Nepal, a developing economy. The study was a qualitative study design involving two districts in Nepal, whereby data was collected via key informant interviews (n = 63) and focus group discussions (n = 12). Thematic analysis of the qualitative data was performed, and a causal loop diagram was built to illustrate the dynamic interactions of the social determinants of NCDs based on the themes. The study also involved sense-making sessions with policy level and local stakeholders. Four key interacting themes emerged from the study describing current dietary and physical activity practices, influence of junk food, role of health system and socio-economic factors as root causes. While the current dietary and physical activity-related practices within communities were unhealthy, the broader determinants such as socio-economic circumstances and gender further fuelled such practices. The health system has potential to play a more effective role in the prevention of the behavioural and social determinants of NCDs.
Determinants of mortality among hospitalized patients with COVID-19 during first and second waves of the pandemic: A retrospective cohort study from an isolation center in Kano, Nigeria
Authors: Dayyab Farouq Muhammad , Bashir Hussain Abdullahi , Sulaiman Abdulwahab Kabir , Iliyasu Garba , Hamza Muhammad , Yakasai Ahmad Maifada , Nashabaru Ibrahim , Saidu Hadiza , Ahmad Bashir Garba , Dabo Bashir , Abubakar Aminu Yusuf , Idris Ibrahim Musa , Yahaya Abdulrauf Sani , Ado Mustapha , Abdurrahman Ibrahim Sabo , Usman Hafizu Musa , Bello Mohammed Kabiru , Jaafar Jaafar Suleiman , Abdullahi Anifowose , Alhassan Abubakar Muhammad , Ahmad Abdulmalik , Allen Alika Ehima , Ezekiel Medu Oghenekevwe , Umar Muhammad Abdullahi , Abdullahi Muhammad B. , Sulaiman Sahabi Kabir , Hussaini Tijjani , Umar Amina Abdullahi , Tsanyawa Aminu Ibrahim , Shuaibu Sabitu Y. , Kabo Nasir Alhassan , Muhammad Basheer Lawan , Yahaya Mohammed Nura , Bello Imam Wada , Rajab Ashiru , Daiyab Abdulhakim Muhammad , Kabara Aminu Faruk , Garko Muhammad Sule , Habib Abdulrazaq Garba
Published: February 2023

Background

Coronavirus disease 2019 (COVID-19) has emerged as an important cause of morbidity and mortality worldwide.

The aim of this study is to identify the clinical predictors of mortality among patients with COVID-19 pneumonia during first and second waves in a treatment center in northwestern Nigeria.

Methods

This was a retrospective cohort study of 195 patients hospitalized with COVID-19 between April 2020 to March 2021 at a designated COVID-19 isolation center in Kano State, Northwest Nigeria. Data were summarized using frequencies and percentages. Unadjusted odds ratios and 95% confidence intervals and p-values were obtained. To determine independent determinants of mortality, we performed a stepwise multivariate logistic regression model.

Results

Of 195 patients studied, 21(10.77%) patients died. Males comprised 158 (81.03%) of the study population. In the adjusted stepwise logistic regression analysis, age>64 years (OR = 9.476, 95% CI: 2.181–41.165), second wave of the pandemic (OR = 49.340, 95% CI:6.222–391.247), cardiac complications (OR = 24.984, 95% CI: 3.618–172.508), hypertension (OR = 5.831, 95% CI:1.413–24.065) and lowest systolic blood pressure while on admission greater than or equal to 90mmHg were independent predictors of mortality (OR = 0.111, 95%CI: 0.021–0.581).

Conclusion

Strategies targeted to prioritize needed care to patients with identified factors that predict mortality might improve patient outcome.
Fuentes para el estudio de las consecuencias sociales de la COVID-19. Una revisión de las encuestas realizadas en España (2020-2021)
Authors: Torrado José Manuel , Duque-Calvache Ricardo , Castellano García Laura , Fernández-Pérez Ángel
Published: February 2023

Los cambios causados por la crisis de la COVID-19 han sido objeto de gran atención por parte de la investigación social. Sin embargo, su volumen es tal que muchas de las encuestas han pasado desapercibidas, siguiendo a día de hoy infrautilizadas. Este trabajo presenta una revisión de las diferentes encuestas sociales específicas sobre COVID-19 realizadas por las instituciones públicas en España, con un doble objetivo. De un lado, servir de herramienta de consulta para investigadores que quieran emprender un trabajo de investigación sobre la pandemia con datos secundarios. De otro, plantear una reflexión a partir del metaanálisis de las características y evolución de las encuestas producidas. Nuestros resultados muestran que la producción de información sigue un curso similar al de la propia enfermedad, y con cada oleada se desataba también un periodo de gran producción de datos. Al tiempo también se produjo una evolución de los temas y bloques de preguntas, que inicialmente se centraban en aspectos de vida cotidiana, después en los impactos sobre la economía y sociedad, posteriormente en la gestión política y finalmente, con el comienzo de la vacunación, en temas de salud.
Discurso político en redes sociales sobre el colectivo minoritario inmigrante: análisis de las narrativas e implicaciones educativas
Authors: Galindo Héctor , García-Magariño Sergio , Losada Daniel
Published: February 2023

En un clima de polarización como el que se vive actualmente, el recurso al miedo y a la descalificación, tan común en las estrategias políticas electoralistas, se topa con límites éticos y legales vinculados al discurso del odio y al enaltecimiento del terrorismo. Por ello, estudiar las dinámicas de redes que rozan la radicalización violenta, en general, y los discursos del odio, en particular, se torna vital. El objetivo del presente estudio es, en primer lugar, caracterizar los discursos en torno a la inmigración que proceden de los representantes políticos de los partidos principales de España y, en segundo lugar, evaluar dichos discursos en función del nivel de riesgo en el que incurren de cometer delitos relacionados con el discurso del odio. Para este fin, se utiliza una red social como sistema de análisis, Twitter, en la que se analizan 500 tweets relacionados con las palabras «inmigrantes», «menas» y «refugiados» de un total de 132.249 tweets de los diversos partidos políticos más influyentes. Los hallazgos apuntan a la existencia de un patrón estadísticamente significativo y antagónico entre los discursos de los partidos políticos PSOE y Vox ante la inmigración ilegal. Concretamente, se aprecia cómo mientras el primero destaca la parte más humanística de la inmigración y considera que es un problema que debe ser tratado internacionalmente, el segundo subraya las consecuencias negativas que puede tener esta situación en la seguridad de la ciudadanía española. Finalmente, se proponen diversas implicaciones educativas relacionadas con la competencia mediática y el empoderamiento del profesorado y del alumnado.
O uso da cartografia social na construção do turismo comunitário
Authors: Santos Lara Maia dos , Santos Camila Dutra dos
Published: February 2023

O Território quilombola-pesqueiro do Cumbe passa por conflitos devido à presença de empreendimentos chamados “desenvolvimentistas”, tais como a carcinicultura e a energia eólica, que privam o território e impedem os modos de vida dos(as) quilombolas. A comunidade vê no turismo comunitário uma forma de resistência dos seus costumes e vivências, e a cartografia social surge como metodologia de reconhecimento territorial. O objetivo geral do artigo é entender como a cartografia social pode ser utilizada como ferramenta para visibilizar os sujeitos e suas atividades cotidianas e culturais no mesmo mapa, utilizando das práticas da pesquisa participativa desenvolvidas em projetos de extensão universitária. A cartografia social surge então como importante ferramenta de pesquisa para a visibilização dos territórios e comunidades tradicionais.
Fechamento de escolas no campo e seus rebatimentos na reprodução social camponesa
Authors: Lima Tiago Barreto , Santos Geovanio Silva , Carvalho Tereza Simone Santos de
Published: February 2023

O campo brasileiro é historicamente marcado por contradições estruturais. Na década de 1990, por pressões dos movimentos sociais de luta pela terra, em especial, do Movimento dos Trabalhadores Rurais Sem Terra, o debate sobre uma educação do/para o campo se intensificou. De um lado, o Agronegócio buscou capitanear essas demandas dos movimentos sociais para a formação de quadros necessários ao manejo dos avanços tecnológicos voltados à sua reprodução. De outro, a Educação do Campo obteve avanços a ponto de se transformar em política pública. Concomitantemente, ante a intensificação do neoliberalismo no Brasil, observou-se o retrocesso, com o fechamento de boa parte das escolas no campo. Tendo isso em mente, objetivamos neste artigo discutir o fechamento de escolas no campo e seus desdobramentos para a reprodução camponesa tomando como referência o município de Moita Bonita – SE. A pesquisa, de cunho quali-quantitativo, contou com levantamento de dados junto aos órgãos oficiais e entrevistas semiestruturada com grupos focais. Os dados foram analisados à luz do materialismo histórico dialético e apontaram como conclusões a compreensão do fechamento de escolas no campo como expressão do modo de sociabilidade do capital, que busca negar os sujeitos e seus lugares, afirmando sua lógica sistêmica de reprodução.
Participação da agricultura familiar no Programa Nacional da Alimentação Escolar durante a pandemia da COVID-19 em municípios do estado de Goiás
Authors: Silva Emanuel Jeremias Ramalho da , Corcioli Graciella , Cruz Fabiana Thomé da
Published: February 2023

O presente estudo se dedica a analisar a participação da agricultura familiar no Programa Nacional de Alimentação Escolar (PNAE) em municípios da Microrregião do Rio Vermelho, no estado de Goiás, no primeiro ano de pandemia da COVID-19. O estudo se deu em sete municípios: Araguapaz-GO, Aruanã-GO, Britânia-GO, Faina-GO, Goiás-GO, Matrinchã-GO e Santa Fé de Goiás-GO. Foi verificado que houve uma queda na aquisição de gêneros alimentícios da agricultura em todos os municípios analisados, com destaque para o município de Goiás-GO que não adquiriu qualquer valor da agricultura familiar, muito embora seja o que detém o maior volume de recursos repassados e onde estão localizados boa parte da agricultura familiar da região. Diante do estudo apresentado, apurou-se, ainda, que houve aumento nos recursos repassados pelo FNDE em 2020. A participação, antes e durante a pandemia, se deu de forma majoritária de agricultores familiares individuais, com exceção do município de Goiás-GO que, em 2019, contratou exclusivamente de grupos formais. A partir do estudo aprofundado do período pandêmico, verificou-se que a agricultura familiar esteve vulnerável à falta de gestão eficiente do PNAE, o que pode indicar ausência de planejamento de compras institucionais sólido e bem articulado com a agricultura familiar.
Abrasion Resistance and Water Absorption Characteristics of Ti-HAp Hybrid Reinforced Polyetheretherketone Biocomposites
Authors: Itua Agbeboh Newton , Oluwole Oladele Isiaka , Ojo Daramola Oluyemi , Hope Adegun Miracle
Published: February 2023

The influence of abrasion on biomedical implant in human body is a constant cause of pain, discomfort and sometimes a repeat of surgery as a result of the complications from the effects of wear on the implants and the negative consequences of the resultant abrasive particles on the surrounding tissue and bodily environment. To alleviate this, a titanium-hydroxyapatite hybrid reinforced polyetheretherketone (PEEK) biocomposite material was developed, characterized and tested. X-Ray Diffraction characterization revealed that the calcined eggshell was composed mainly of lime and portlandite. The calcined eggshell was then used in the synthesis of hydroxyapatite powder (HAp) with characteristic bands confirmed by FTIR spectroscopic analysis. Biocomposites were developed from the blend of titanium and hydroxyapatite powders in varying proportions as reinforcements in PEEK matrix. The developed composites and control sample were subjected to abrasion and water absorption tests from where it was revealed that biocomposite sample reinforced with 10 wt.% orthophosphoric acid synthesized eggshell possess optimum abrasion resistance with a wear index of 0.20 mg/cycle with an acceptable level of water absorption next to the unreinforced polyetheretherketone over a period of 35 days.
Children’s Physical Health and Implementation of Post-Pandemic Healthy Behavior
Authors: Kuswanto Cahniyo Wijaya , Pratiwi Dona Dinda , Denata Galuh Yuliar
Published: February 2023

Purpose – The physical condition of children needs to be analyzed in the field, whether COVID-19 affects their health or not, and how to implement post-pandemic healthy living behaviours in the school and community environment so that children are truly safe when hanging out with their friends.Design/methods/approach – This research uses a case study qualitative method by collecting data using observation, interviews, and document analysis. Source triangulation is a means to assist in the validity of the data.Findings – The results showed that the children’s physical health began to improve. It is supported by the current improvement in children’s health, as well as free physical activity that can be carried out at school or in the community. In addition, a COVID vaccine helps the child’s immune system to be more robust against disease. The implementation of clean and healthy living behaviours in schools and the community is very supportive, as evidenced by hand-washing equipment in every corner of the house and school.Research implications/limitations – The limitations of this study are the narrow research subjects, so general conclusions cannot be drawn. However, the research results can be stakeholder input to invite the public to continue implementing health protocols.Practical implications – The results show field findings found a decline in the prokes provision of infrastructure for clean and healthy living behavior in schools and the community.Originality/value – This study proves that young children are far away from COVID-19. It is proven at home and school. Many children are in good health and fit and doing everyday activities.Paper type: Research paper
PENGUKURAN KUALITAS LAYANAN BERDASARKAN DIMENSI SERVICE QUALITY (SERVQUAL) DENGAN METODE ZONE OF TOLERANCE (ZOT) DAN KANO PADA PET WORLD
Authors: Rahmawati Dewi , Aulawi Hilmi , Kurniawati Rina
Published: February 2023

Pet World merupakan salah satu jasa pelayanan kebutuhan hewan peliharaan yang berada di Kabupaten Garut, namun pemenuhan tingkat kepuasan pelanggan belum dapat dilakukan secara optimal. Tujuan dari penelitian ini adalah untuk mengetahui tingkat layanan berdasarkan pada dimensi kualitas yang diberikan terhadap kepuasan pelanggan serta menghasilkan usulan perbaikan untuk meningkatkan kualitas layanan pada Pet World. Penelitian ini menggunakan pendekatan Mix Method dimana data kualitatif dilakukan untuk menguji validitas dan reliabilitas. Sedangkan data kuantitatif digunakan untuk pengolahan metode Servqual untuk mengukur kepuasan pelanggan, metode ZOT untuk mengukur apakah pelayanan masih dalam batas toleransi, dan metode kano untuk mengukur prioritas.Hasil penelitian menunjukan bahwa atribut layanan yang tidak memuaskan atau atribut yang memiliki gap score negatif yaitu dua atribut pada dimensi tangibles dalam segi kenyamanan dan keamanan, satu atribut pada dimensi reliability pada segi ketepatan dalam produk serta satu atribut pada dimensi responsivenes pada segi akses informasi. Selain itu, metode Servqual, ZOT, dan Kano relevan dengan penelitian yang dilakukan karena pada metode ini mengukur kualitas layanan berdasarkan pada dimensi kualitasnya serta berorientasi pada kepuasan pelanggan. Abstract[Measurement of Service Quality Based on Service Quality (Servqual) Dimensions With Zone of Tolerance (ZOT) and Kano on Pet World] Pet World is one of the services for pet needs in Garut Regency, but the fulfillment of the customer satisfaction level has not been optimal. The purpose of this study was to know the level of service based on the dimensions of quality provided to customer satisfaction and to produce suggestions for improvements to improve service quality at Pet World. This study used a Mix Method approach. The Qualitative data was used to test the validity and reliability. The quantitative data was used for processing the Servqual method to measure customer satisfaction, the ZOT method to measure whether the service is still within tolerance limits, and the Kano method to measure priority. The results showed unsatisfactory service attributes or attributes with a negative gap score were two attributes on the tangibles dimension in terms of comfort and security, one on the reliability dimension in terms of product accuracy, and one on the responsiveness dimension in terms of access to information. In addition, the Servqual, ZOT, and Kano methods are relevant to the research conducted because this method measures service quality based on its dimensions and does orient to customer satisfaction.Keywords: Kano; Mix Method; service quality; zone of tolerance
SUSTAINABLE FASHION FROM PRODUCT SERVICE SYSTEM PERSPECTIVE: A LITERATURE REVIEW
Authors: Paramita Dhyana
Published: February 2023

Fast fashion perpetuates the perception that clothing products are cheap and are easily disposed of. Consequently, the fashion industry contributes great concern for environmental impact. Product-service system (PSS) may serve as an integrated product-service solution to support sustainable fashion. While there is an increasing trend in PSS studies, the literature studies in fashion PSS remains limited. This paper aims to explore the research topics in fashion PSS studies by examining topics addressed in fashion PSS literature, how PSS may contribute to sustainability in the context of the fashion industry, as well as positive and negative value perceived consumers in adopting PSS fashion. The research is conducted through literature review retrieved from Scopus and analyzed according to the aim of this paper. The results show that topics addressed in fashion PSS are related to potential drivers and barriers to adopt PSS fashion, business model, environmental impact, and life cycle analysis. The role of PSS in the fashion context is product and use-oriented. The consumer perception on adopting PSS fashion is classified as emotional, functional, social, financial, environmental, and psychological aspects.
New data on the recently described Brazilian Cerrado hotspot endemic Cerradomys akroai Bonvicino, Casado et Weksler, 2014 (Rodentia: Cricetidae)
Authors: Bezerra Alexandra M. R. , Weksler Marcelo
Published: February 2023

Cerradomys akroai is a recently described rodent species, known from two localities in the Brazilian Cerrado, in southeastern Tocantins state (type locality), and in southwestern Piauí state. Herein we add a third locality recorded from a specimen collected in central Tocantins state, in a “cerrado sensu stricto” habitat. Morphological and molecular analyses confirm the identification. The three localities now known for the species are restricted to northern Cerrado domain, and two are located in sites severely impacted by anthropogenic activities. Current conservation category of Cerradomys akroai is Data Deficient, and additional information on its distribution and biology is required.
Photoredox-catalyzed three-component difluorobenzylation of quinoxalin-2(1H)-ones with unactivated vinylarenes and BrCF2CO2Et/HCF2CO2H
Authors: Shen Lu , Yuan Jin-Wei , Zhang Bing , Song Sai-Yi , Yang Liang-Ru , Xiao Yong-Mei , Zhang Shou-Ren , Qu Ling-Bo
Published: February 2023

An environmentally friendly strategy for the photo-catalyzed three-component reaction between quinoxalin-2(1H)-ones, vinylarenes, with inexpensive and easily accessible ethyl bromodifluoroacetate/sodium difluoromethanesulfinate is described. This protocol exhibits mild conditions, high efficiency, and excellent functional group tolerance, providing a highly efficient approach for the synthesis of difluorobenzylated quinoxalin-2(1H)-ones by the formation of two carbon-carbon bonds. A radical mechanism is responsible for this three-component transformation.
COLLECTIVIZING COMMUNICATIVE SPACES FOR COLLABORATION IN RURAL LODGING IN BRAZIL
Authors: Torres Tricárico Luciano
Published: February 2023

Collectivization and collaboration are categories essentially studied as a social dimension in urban contexts, despite the spatial dimension of rural realities. Given this reality of scientific studies, the research goal was to demonstrate collectivization for collaboration in rural lodging spaces from Sítio Hortêncio (Florianópolis, state of Santa Catarina, Brazil) as a research object. The research is a qualitative and descriptive study in view of space as a communicating empirical object. Bibliography and search in primary and secondary data sources, in loco spatial reading, and photographs of the spaces of the research object as support for spatial reading constituted the research procedures and instruments. First, collected data was approached by Semiotic of Peirce, followed by Benjamin Montage Theory. The semiotic and the montage theory presented themselves as unusual as methodological approaches for the Hospitality industry; the rural lodging space was an innovative attribute of approach for studies in the Hospitality area; rural lodging spaces revealed possibilities of political actions of collaborative, direct democracy for the empowerment of rural communities in Brazil. Collectivization and collaboration have been explained as urban phenomena. Therefore, the description of rural lodging spaces could legitimize other spaces that are not urban public spaces as support for collectivization and collaboration. The results gave meaning to rural lodging spaces, understood as communicators of collectivization for collaboration in the Brazilian rural territory.
Coupling between the Stereocilia of Rat Sensory Inner-Hair-Cell Hair Bundles Is Weak, Shaping Their Sensitivity to Stimulation
Authors: Scharr Alexandra L. , Ó Maoiléidigh Dáibhid , Ricci Anthony J.
Published: February 2023

The hair bundle is the universal mechanosensory organelle of auditory, vestibular, and lateral-line systems. A bundle comprises mechanically coupled stereocilia, whose displacements in response to stimulation activate a receptor current. The similarity of stereociliary displacements within a bundle regulates fundamental properties of the receptor current like its speed, magnitude, and sensitivity. However, the dynamics of individual stereocilia from the mammalian cochlea in response to a known bundle stimulus has not been quantified. We developed a novel high-speed system, which dynamically stimulates and tracks individual inner-hair-cell stereocilia from male and female rats. Stimulating two to three of the tallest stereocilia within a bundle (nonuniform stimulation) caused dissimilar stereociliary displacements. Stereocilia farther from the stimulator moved less, but with little delay, implying that there is little slack in the system. Along the axis of mechanical sensitivity, stereocilium displacements peaked and reversed direction in response to a step stimulus. A viscoelastic model explained the observed displacement dynamics, which implies that coupling between the tallest stereocilia is effectively viscoelastic. Coupling elements between the tallest inner-hair-cell stereocilia were two to three times stronger than elements anchoring stereocilia to the surface of the cell but were 100–10,000 times weaker than those of a well-studied noncochlear hair bundle. Coupling was too weak to ensure that stereocilia move similarly in response to nonuniform stimulation at auditory frequencies. Our results imply that more uniform stimulation across the tallest stereocilia of an inner-hair-cell bundlein vivois required to ensure stereociliary displacement similarity, increasing the speed, sensitivity, and magnitude of the receptor current.

SIGNIFICANCE STATEMENTGeneration of the receptor current of the hair cell is the first step in electrically encoding auditory information in the hearing organs of all vertebrates. The receptor current is shaped by mechanical coupling between stereocilia in the hair bundle of each hair cell. Here, we provide foundational information on the mechanical coupling between stereocilia of cochlear inner-hair cells. In contrast to other types of hair cell, coupling between inner-hair-cell stereocilia is weak, causing slower, smaller, and less sensitive receptor currents in response to stimulation of few, rather than many, stereocilia. Our results imply that inner-hair cells need many stereocilia to be stimulatedin vivoto ensure fast, large, and sensitive receptor currents.
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2
Authors: Jiang Honghui , Ariyoshi Mariko , Hori Tetsuya , Watanabe Reito , Makino Fumiaki , Namba Keiichi , Fukagawa Tatsuo
Published: February 2023

Centromere protein A (CENP‐A) nucleosomes containing the centromere‐specific histone H3 variant CENP‐A represent an epigenetic mark that specifies centromere position. The Mis18 complex is a licensing factor for new CENP‐A deposition via the CENP‐A chaperone, Holliday junction recognition protein (HJURP), on the centromere chromatin. Chicken KINETOCHORE NULL2 (KNL2) (ggKNL2), a Mis18 complex component, has a CENP‐C‐like motif, and our previous study suggested that ggKNL2 directly binds to the CENP‐A nucleosome to recruit HJURP/CENP‐A to the centromere. However, the molecular basis for CENP‐A nucleosome recognition by ggKNL2 has remained unclear. Here, we present the cryo‐EM structure of the chicken CENP‐A nucleosome in complex with a ggKNL2 fragment containing the CENP‐C‐like motif. Chicken KNL2 distinguishes between CENP‐A and histone H3 in the nucleosome using the CENP‐C‐like motif and its downstream region. Both the C‐terminal tail and the RG‐loop of CENP‐A are simultaneously recognized as CENP‐A characteristics. The CENP‐A nucleosome–ggKNL2 interaction is thus essential for KNL2 functions. Furthermore, our structural, biochemical, and cell biology data indicate that ggKNL2 changes its binding partner at the centromere during chicken cell cycle progression.
L‐arginine homeostasis governs adult neural stem cell activation by modulating energy metabolism in vivo
Authors: Xu Mingyue , Guo Ye , Wang Min , Luo Xing , Shen Xuning , Li Zhimin , Wang Lei , Guo Weixiang
Published: February 2023

Neurogenesis in the developing and adult brain is intimately linked to remodeling of cellular metabolism. However, it is still unclear how distinct metabolic programs and energy sources govern neural stem cell (NSC) behavior and subsequent neuronal differentiation. Here, we found that adult mice lacking the mitochondrial urea metabolism enzyme, Arginase‐II (Arg‐II), exhibited NSC overactivation, thereby leading to accelerated NSC pool depletion and decreased hippocampal neurogenesis over time. Mechanistically, Arg‐II deficiency resulted in elevated L‐arginine levels and induction of a metabolic shift from glycolysis to oxidative phosphorylation (OXPHOS) caused by impaired attachment of hexokinase‐I to mitochondria. Notably, selective inhibition of OXPHOS ameliorated NSC overactivation and restored abnormal neurogenesis in Arg‐II deficient mice. Therefore, Arg‐II‐mediated intracellular L‐arginine homeostasis directly influences the metabolic fitness of neural stem cells that is essential to maintain neurogenesis with age.
Ubiquitylation of BBSome is required for ciliary assembly and signaling
Authors: Chiuso Francesco , delle Donne Rossella , Giamundo Giuliana , Rinaldi Laura , Borzacchiello Domenica , Moraca Federica , Intartaglia Daniela , Iannucci Rosa , Senatore Emanuela , Lignitto Luca , Garbi Corrado , Conflitti Paolo , Catalanotti Bruno , Conte Ivan , Feliciello Antonio
Published: February 2023

Bardet‐Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, renal abnormalities, postaxial polydactyly, and developmental defects. Genes mutated in BBS encode for components and regulators of the BBSome, an octameric complex that controls the trafficking of cargos and receptors within the primary cilium. Although both structure and function of the BBSome have been extensively studied, the impact of ubiquitin signaling on BBSome is largely unknown. We identify the E3 ubiquitin ligase PJA2 as a novel resident of the ciliary compartment and regulator of the BBSome. Upon GPCR‐cAMP stimulation, PJA2 ubiquitylates BBSome subunits. We demonstrate that ubiquitylation of BBS1 at lysine 143 increases the stability of the BBSome and promotes its binding to BBS3, an Arf‐like GTPase protein controlling the targeting of the BBSome to the ciliary membrane. Downregulation of PJA2 or expression of a ubiquitylation‐defective BBS1 mutant (BBS1K143R) affects the trafficking of G‐protein‐coupled receptors (GPCRs) and Shh‐dependent gene transcription. Expression of BBS1K143R in vivo impairs cilium formation, embryonic development, and photoreceptors' morphogenesis, thus recapitulating the BBS phenotype in the medaka fish model.
Characterization of the clientele attended in a Psychosocial Care Center - alcohol and drugs
Authors: Oliveira Eliany Nazaré , Silva Maria Wanessa Pereira , Eloia Sara Cordeiro , Mororó Francisca Waldiane Pereira , Lima Gleisson Ferreira , Matias Manuelle Maria Marques
Published: February 2023

This documentary and retrospective study aimed to analyze the profile of the clientele attended in the Psychosocial Care Center Alcohol and Other Drugs from Sobral, Ceará, Brazil in 2010, based on 300 records. Males predominated with 75% (n=225), with age ranging from 11 to 29 years old with 44.3% (n=133), single with 49% (n=147), and with elementary school 45.7% (n=137). The most commonly used drug among men was crack, 31.3% (n=94), and among women, tobacco, 12% (n=36). The losses associated with dependence, are mostly related to the family, with 31.3% (n=94). The highlight to crack requires changes in the care process implemented in institutions. One should remain alert to these new profiles related to chemical dependency, so that quality and integral care can be offered to this clientele.
Stress and coping among nurses of hemato-oncologic units
Authors: Umann Juliane , Silva Rodrigo Marques da SilvaRodrigo Marques da , Benetti Eliane Raquel Rieth , Guido Laura de Azevedo
Published: February 2023

We analyzed stress and Coping strategies used by Hemato-Oncology Unit nurses of a Rio Grande do Sul University Hospital. This is a descriptive, cross-sectional and quantitative study, conducted between March and April 2010. We applied a Form to sociodemographic characterization, Nurses Stress Inventory and Occupational Coping Scale in 18 nurses. We identified 55.55% of nurses in low stress. "Intrinsic Factors for Job" and "Feel emotional distress with work" represented higher stress for nurses. Control was the factor more used to deal with stressors and, in this factor, "I try to do what i think is expected of me" the action more used to manage them. Nurses use problem-centered Copingstrategies, considered more effective to deal with stressors. Therefore, they can have evaluated work in hemato-oncology unit as low-stress.
The teaching about the care of the elderly in nursing training: the situation in PortugalThe teaching about the care of the elderly in nursing training: the situation in Portugal
Authors: Santos Silvana Sidney Costa , Lopes Manuel José , Gemito Maria Laurência , Casas-Novas Maria Vitória , Pinheiro Felícia Tavares
Published: February 2023

This paper aims to look at the teaching situation of the nursing undergraduate degree’s courses about eldercare in Portugal. A documentary research on the teaching programs in 39 nursing schools, 26 schools presented syllabus units related to the topic ‘eldercare’ and in eight of these schools the contents of the units were identified. Using textual analysis and from the categories we concluded that the teaching regarding eldercare for the nurse training in Portugal is focused on hospital care; it is directed to the adult/elderly/family; it explores the definitions related to the aging process; it explores community issues, legislation and research. People responsible for the design/monitoring of teaching programs should include teaching regarding eldercare in the nurse training, considering that the elder population is increasing in Portugal.
Round-table discussion in the process of mental health continuing education
Authors: Ramos Luciane Silva , Beck Carmem Lúcia Colomé , Silva Gilson Mafacioli da , Silva Rosângela Marion da , Dissen Caliandra Marta
Published: February 2023

This study aimed to describe an experience report on the use of round-table discussion strategy as driver of Healthcare continuing education in the context of Psychiatric Reform. This is a descriptive study that used participatory methodology with workers of four health regions of a municipality located in Rio Grande do Sul, Brazil. We identified the potential of the first movements of the strategy entitled Mental Health in Discussion in displacing the Primary Healthcare Workers, in the sense of reviewing their practices and their perspective on users in mental distress. It was concluded that the strategy used can enhance the process of Healthcare continuing education in the context of Psychiatric Reform, even as a new proposal, subject to modifications, and that is drawing its own course in each round.
Logbook: experience of teaching-learning management and management in nursing and health
Authors: Santos José Luís Guedes dos , Pestana Aline Lima , Guerrero Patrícia , Klock Patrícia , Erdmann Alacoque Lorenzini
Published: February 2023

The article aimed at reporting an experience of a group of post-graduate students in teaching on the stage of implementation active teaching-learning methodologies in the discipline of Management in Nursing and Health. The experience happened in three different admission units of a federal hospital in the southern region of the country, in the second semester of 2010. We used a logbook for students to register the journey to deepen the reflections on the experiences of the actions of management. At the end of the internship, the students were asked the logbook so that experiences, feelings, anxieties generated in the course of the journey to knowledge could be identified. The students report that the curricular internship of Management in Nursing and Health is a process of construction that gradually allows to have a sense of what awaits them when they are professionals, thus contributing to a critical and reflective formation.
Monitoring children’s health in a public daycare center: focus on their nutritional profile
Authors: Santos Nathanielly Cristina Carvalho de Brito , Pinto Maria Benegelania , Henriques Amanda Haissa Barros , Cavalcanti Joseane da Rocha Dantas , Brito Cristhianne Carvalho de , Reichert Altamira Pereira da Silva
Published: February 2023

One aimed to identify the nutritional profile of children in a public daycare center in the city of Cuité-Paraíba, from the perspective of health surveillance. This is a cross-sectional, exploratory-descriptive, field study with a quantitative approach, performed in 2011, with 55 children from 6 to 60 months of life, assisted full time in a public daycare center, who met the selection criteria: be attending the daycare center; and not present any disability. One used for evaluation the anthropometric measurements of weight, height and Body Mass Index, according to the growth curve suggested by the Ministry of Health. One identified that 96.4% had adequate nutritional status, however, 7.3% had overweight risk and 3.6% underweight risk, especially girls. It is important to raise managers’, professionals’ and parents’ awareness about the health surveillance of children in daycare centers for identification and intervention against nutritional changes, encouraging an adequate child growth.
Profile of potential organ donors in a reference hospital
Authors: Rodrigues Thamy Braga , Chagas Maristela Inês Osawa , Brito Maria da Conceição Coelho , Sales Diane Sousa , Silva Regina Célia Carvalho da , Souza Ângela Maria Alves e
Published: February 2023

The study aimed to characterize the profile of potential organ donors in a hospital in the northern zone of Ceará, Brazil. This is a quantitative, retrospective and documentary study, performed in a hospital of Ceará, from information contained in the medical records of potential donors, from May to September 2009. Data were tabulated, focusing on the identification process and logistic aspects. We identified that the most prevalent diagnoses were traumatic brain injury (51.4%) and stroke (31.4%), and that 57.1% completed the process in time for organ procurement. Thus, we hope that the assessment of policy and donation data contributes to increase the donation rates, supporting the recognition of the process’s weaknesses, as well as the implementation of measures to promote its success.
Nursing diagnoses, interventions and outcomes in the bariatric surgery postoperative care
Authors: Moreira Rosa Aparecida Nogueira , Barros Lívia Moreira , Rodrigues Andrea Bezerra , Caetano Joselany Áfio
Published: February 2023

One aimed to identify the nursing diagnoses of the cardiovascular/pulmonary response class belonging to the activity/rest domain, according to the taxonomy II of NANDA-I in patients in the bariatric surgery immediate postoperative period and propose the interventions and nursing outcomes according to the Nursing Interventions Classification and the Nursing Outcomes Classification. This exploratory and cross-sectional study was carried out from July 2010 to June 2011 with 59 patients in the bariatric surgery immediate postoperative period. The most frequent nursing diagnoses were: Ineffective Peripheral Tissue Perfusion; Decreased Cardiac Output; Activity Intolerance; Risk for Decreased Cardiac Tissue Perfusion; and Risk for Ineffective Renal Perfusion. A nursing care plan was constructed with 16 interventions and 10 expected outcomes. The choice of appropriate interventions decreases hospitalization time and consequently the cardiopulmonary complications in the postoperative period. Another important issue is the standardization of language in the construction of the diagnoses and outcomes, which improves nursing documentation.
Work process and management competences of the nurses in the family health strategy
Authors: Paula Marcilene de , Peres Aida Maris , Bernardino Elizabeth , Eduardo Elizabete Araújo , Macagi Silvânia Terezinha Silva
Published: February 2023

The objective was to identify the dimension of the process of nursing work in a unit of the Family Health Strategy and correlate the necessary competences for the development of managerial activities. It is a descriptive study using the technique of non-participant observation during 160 hours of activities of four nurses from a unit of the Family Health Strategy, from March to May, 2011. The results showed that the care dimension holds 42% of the time spent by nurses in their activities, followed by management (33%), education (20%) and political participation (2.5%). In managerial dimension, managerial competences were classified as follows: communication (55%), leadership (33%), permanent education (8%) and decision making (4%). These competences are interrelated and developed together with administrative functions: planning, coordination, direction and control. For the development of their attributions in the Family Health Strategies the nurse professionals uses administrative tools demanding constant mobilization of different competences.
Senses of the being-there-woman-after-cardiac-surgery supported by Heidegger
Authors: Amorim Thaís Vasconselos , Salimena Anna Maria de Oliveira , Cardoso de Melo Maria Carmen Simões , Souza Ívis Emília de Oliveira , Silva Lúcia de Fátima da
Published: February 2023

Qualitative study aimed at presenting the unveiling of the senses of the being-there-woman-after-cardiac-surgery supported by Heidegger´s referential. The setting was a hospital accredited for performing highly complex cardiovascular procedures in Minas Gerais, Brazil. The field stage occurred in December 2011 and January 2012, and the subjects interviewed from the following question: How is your day-by-day after the cardiac surgery? The readings and recorded speeches enabled a comprehensive analysis and interpretation. It was learned that the woman shown in publicity, dominated by impersonal behavior in their speeches, curiosity and ambiguity. That reveals the inadequacy in the fear facing horror and terror, towards decadence. Facing the existential procedures, one can understand that as a being-in-the-world, the woman covered herself with the will to take care of herself, pointing a gap to be filled by the nurses through health promotion which should be in their practice.
Catheter-associated urinary tract infection: antimicrobial sensitivity profile*
Authors: Almeida Barros Silvana Kelie Souza de , Kerbauy Gilselena , Dessunti Elma Mathias
Published: February 2023

This descriptive quantitative study aimed to analyze the prevalence of microorganisms and the antimicrobial sensitivity profile from urine cultures of patients with catheter-associated urinary tract infection. We reviewed 394 medical records of adults hospitalized in the Intensive Care Units of the University Hospital of Londrina, Paraná, Brazil, from April to December 2011. The prevalence of catheter-associated urinary tract infection was of 34.0% (134) and 2.2% (3) of these patients developed sepsis. The most common microorganisms found in the urine cultures wereCandida sp (44.4%), Acinetobacter baumannii (9.7%) andPseudomonas aeruginosa (9.2%). This last one showed resistance of 86.7% to third-generation cephalosporins and the Acinetobacter baumannii showed resistance of 83.3% to carbapenems. Klebsiella pneumonia had 87.5% of resistance to third and fourth generation cephalosporins and 75.0% to carbapenems. We concluded that bacterial resistance is frequent in catheter-associated urinary tract infection and that we should emphasize the control measures.This descriptive quantitative study aimed to analyze the prevalence of microorganisms and the antimicrobial sensitivity profile from urine cultures of patients with catheter-associated urinary tract infection. We reviewed 394 medical records of adults hospitalized in the Intensive Care Units of the University Hospital of Londrina, Paraná, Brazil, from April to December 2011. The prevalence of catheter-associated urinary tract infection was of 34.0% (134) and 2.2% (3) of these patients developed sepsis. The most common microorganisms found in the urine cultures wereCandida sp (44.4%), Acinetobacter baumannii (9.7%) andPseudomonas aeruginosa (9.2%). This last one showed resistance of 86.7% to third-generation cephalosporins and the Acinetobacter baumannii showed resistance of 83.3% to carbapenems. Klebsiella pneumonia had 87.5% of resistance to third and fourth generation cephalosporins and 75.0% to carbapenems. We concluded that bacterial resistance is frequent in catheter-associated urinary tract infection and that we should emphasize the control measures.
Development of a theoretical guide for nursing care in cardiac arrest
Authors: Silva Aliandra Bittencourt da , Machado Regimar Carla
Published: February 2023

This study aimed to identify the knowledge on cardiorespiratory arrest among nurses in a hospital of Vale do Paraíba, São Paulo, Brazil, and develop a theoretical guide for care of this emergency. We prepared an instrument of data collection based on relevant literature and the 2010 AHA Guidelines for CPR, from August to October 2012. The sample consisted of 41 nurses who deliver care activities in various units of the hospital. The study showed that professional participants said they were able to act in cardiopulmonary resuscitation, however, there were limitations of knowledge about the theme. Given the above, we developed a theoretical guide for cardiac arrest care based on scientific literature and covering questions submitted by nurses.
Labor fatigue in rural workers
Authors: Oliveira Karla Nayalle de Souza , Bezerra Leilson Rocha , Bezerra Maria Augusta Rocha , Oliveira Kaline Nayanne de Souza , Carneiro Cristianne Teixeira
Published: February 2023

This is a research to identify the existence of labor fatigue in rural workers in Bom Jesus-PI, Brazil. This is a descriptive-exploratory study carried out from April to June, 2011, with 47 workers. Data collection took place by applying an instrument for evaluation of fatigue called "Bipolar Questionnaire" and semi-structured interview script and form to characterization of the socio-demographic profile and working conditions. The questionnaire was tabulated, being compared by Chi-Square test with 95% of reliability. It was performed for differentiation and classification of answers analyzed and observation of behavior within groups, the analysis of the main components and groups. It was observed that fatigue is common in a rural environment, mainly in the form of intense fatigue, due to the exposure to unhealthy conditions for the worker. Although they do not directly identify its trigger factors and therefore, their preventive measures.
Continuing healthcare education: a strategy to connect teaching and services
Authors: Filho Luiz Alves Morais , Marinho Cristiane da Silva Ramos , Backes Vânia Marli Schubert , Martini Jussara Gue
Published: February 2023

This experience report aims to describe the experience of implementing a project for continuing education with the nursing staff of the emergency service at three hospitals, highlighting the connection between teaching and service. This project was developed by professors and undergraduate nursing students of the Universidade Federal do Rio Grande do Norte in 2011, and conducted at the urgent care services of three hospitals. In each hospital were worked themes chosen by service professionals according to local needs. At the meetings, we used questioning with daily issues, round-table discussions of professional experiences, practical classes in the emergency care facility and laboratory, discussion of texts, and lecture/dialogue classes. The experience of this project reveals the importance and potential of integrating teaching-services in the continuing education of health workers in order to improve care quality and solidify the National Health System in Brazil