bluuebunny/crossref_metadata_2025 huggingface dataset:
A Robust Zn-Hydroxamate Metal–Organic Framework Constructed from an Unsymmetrical Ligand for Iodine Capture
Authors: Song Ting , Zhu Yinning , Li Zhehao , Mei Zhewei , Shao Zhen-Wu , Liu Chong
Published: August 2024

To qualify as competent sorbents for airborne contaminants such as iodine vapor, permanent porosity and chemical stability are key criteria for the selection of candidate metal-organic frameworks (MOFs). To ensure these characteristics, in the present study, an unsymmetrical bifunctional ligand incorporating both carboxylic acid and hydroxamic acid groups was employed for MOF [Zn(CBHA)](DMF) [SUM-13; CPHA = 4-carboxyphenylhydroxamate, DMF = N,N-dimethylformamide] design and synthesis. Though coupled with Zn2+, which does not typically yield kinetically robust MOFs with hard acids, the SUM-13 featuring differentiated coordination modes of chelating, bridging and monodentate bonding exhibited exceptional chemical stability and permanent porosity, with a Brunauer–Emmett–Teller (BET) surface area of 296.9 m2/g and a total pore volume of 0.1196 cm3/g. Additionally, with porosity and open metal sites at the five-coordinate Zn2+ centers, SUM-13 was demonstrated to be an eligible iodine adsorbent, reaching a maximum uptake of 796 mg/g. These findings underscore the validity and potential of the design strategy in constructing stable metal–organic frameworks.
Importance of the Cysteine-Rich Domain of Snake Venom Prothrombin Activators: Insights Gained from Synthetic Neutralizing Antibodies
Authors: Misson Mindrebo Laetitia E. , Mindrebo Jeffrey T. , Tran Quoc , Wilkinson Mark C. , Smith Jessica M. , Verma Megan , Casewell Nicholas R. , Lander Gabriel C. , Jardine Joseph G.
Published: August 2024

Snake venoms are cocktails of biologically active molecules that have evolved to immobilize prey, but can also induce a severe pathology in humans that are bitten. While animal-derived polyclonal antivenoms are the primary treatment for snakebites, they often have limitations in efficacy and can cause severe adverse side effects. Building on recent efforts to develop improved antivenoms, notably through monoclonal antibodies, requires a comprehensive understanding of venom toxins. Among these toxins, snake venom metalloproteinases (SVMPs) play a pivotal role, particularly in viper envenomation, causing tissue damage, hemorrhage and coagulation disruption. One of the current challenges in the development of neutralizing monoclonal antibodies against SVMPs is the large size of the protein and the lack of existing knowledge of neutralizing epitopes. Here, we screened a synthetic human antibody library to isolate monoclonal antibodies against an SVMP from saw-scaled viper (genus Echis) venom. Upon characterization, several antibodies were identified that effectively blocked SVMP-mediated prothrombin activation. Cryo-electron microscopy revealed the structural basis of antibody-mediated neutralization, pinpointing the non-catalytic cysteine-rich domain of SVMPs as a crucial target. These findings emphasize the importance of understanding the molecular mechanisms of SVMPs to counter their toxic effects, thus advancing the development of more effective antivenoms.
Multi-Objective Planting Structure Optimisation in an Irrigation Area Using a Grey Wolf Optimisation Algorithm
Authors: Wu Li , Tian Junfeng , Liu Yanli , Wang Yong , Zhang Peixin
Published: August 2024

To improve agricultural production efficiency, increase farmers’ income, and promote sustainable development, we established a multi-objective optimisation model for crop planting structure in an irrigation area using the grey wolf optimisation (GWO) algorithm to comprehensively consider the resource, economic, and social objectives associated with agriculture. This model was subsequently applied to obtain the optimal planting structure in the southern bank of the Xiaolangdi Reservoir irrigation area in Henan Province, China. The planting areas of wheat, corn, autumn miscellaneous, and economic crops are 30,417; 25,050; 7157; and 1789 hm2, respectively. The irrigation water is 8292.66 × 104 m3, output value of crops is 105,721.37 × 104 CNY, and crop yield is 34,280.31 × 104 kg. Different solutions are used to solve the model to evaluate the results, and the order degree entropy method is used to evaluate and compare the results of multiple solutions. The optimisation scheme obtained with this model is consistent with the evaluation results of the cooperative game optimisation scheme, and the relative order degree entropy is 0.136, which is better than that in other schemes. Thus, the optimisation scheme of crop planting structure obtained via GWO comprehensively considers irrigation water consumption, economic benefits, and crop yield, which ensures coordinated development of resource, economic, and social systems and is conducive to promoting the benign development of the whole irrigation area system.
Cobalt-Based MOF Material Activates Persulfate to Degrade Residual Ciprofloxacin
Authors: Luo Yiting , Su Rongkui
Published: August 2024

Antibiotic residues in water environments have garnered widespread attention. Metal-organic frameworks (MOFs) have found extensive applications in water purification. This study investigates the use of a cobalt-based MOF material, zeolitic imidazolate framework-67(ZIF-67)(Co), for activating persulfate (PMS) to remove residual antibiotic ciprofloxacin (CIP) from aqueous environments. The main findings are as follows: ZIF-67(Co) exhibits insignificant adsorption capacity for CIP, and PMS alone does not degrade CIP effectively. However, ZIF-67(Co)-activated PMS demonstrates the efficient degradation of CIP, following pseudo-second-order reaction kinetics. Under optimal conditions of the catalyst dosage (15 mg) and PMS concentration (1.0 mM), the removal efficiency reaches 88% after 60 min. Comparative analysis of CIP degradation at different initial pH levels shows that the highest efficiency is reached under mildly acidic conditions, with an 86% removal rate achieved within 60 min under these conditions. Investigation into the impact of various inorganic anions on the ZIF-67(Co)-catalyzed PMS degradation of CIP reveals significant inhibition by chloride ions (Cl−), whereas nitrate (NO3-) and sulfate (SO42-) ions have minor effects on the degradation efficiency. The system demonstrates a consistent performance across different water matrices, highlighting ZIF-67(Co)/PMS as effective for ciprofloxacin removal in environmental waters. This study provides technical support for the efficient removal of antibiotic residues.
Dewaterability Enhancement of Anaerobic Sludge Using Polymeric Aluminum Chloride and Polyoxyethylene Alkyl Ether Surfactants
Authors: Song Eunhye , Kim Eunju , Kim Gyeong Woo , Jeong Cheol Jin , Lee Wonbae , Han Seong Kuk
Published: August 2024

The use of coagulants, such as ferric chloride hexahydrate, in wastewater treatment processes is known to induce pipe corrosion and to contribute to the discoloration of treated water. This study explores alternative approaches to sludge dewatering by evaluating the effectiveness of polymeric aluminum chloride (PAC) as a coagulant and polyoxyethylene alkyl ether (POAE) as a surfactant. The impacts of coagulation/flocculation were assessed using time to filtration (TTF) and a pressure filter press. The effects of certain coagulant and surfactant dosages were studied. The inputs were in the range of 105–1750 mg/L for PAC and 28–152 mg/L for POAE, which were determined based on zeta potential (ZP) measurements. The optimal concentrations were 876 mg/L for PAC and 114 mg/L for POAE, resulting in a TTF of less than 1 min. Moreover, the effect of pH on anaerobic sludge dewaterability was investigated. At a low pH below 8, the ZP reached the maximum value, and a higher pH resulted in a reduction in ZP. Under low-pH adjustments, it was observed that the dewatering performance of the POAE surfactant improved more significantly than that of the PAC coagulant. In addition, the effect of pressure was analyzed using a pressure filter under conditions favoring POAE, with relatively lower dosages and greater cost-effectiveness. In order to evaluate the solubility of organic matter under pressurized conditions, the filtrate’s removal efficiency, chemical oxygen demand (COD), and total phosphorus (TP) were investigated. Solubilization did not occur at an increased pressure of around 10 bars. The findings presented in this study provide technical assistance for sludge treatment.
Patient Preferences and Priorities for the Design of an Acute Kidney Injury Prevention Trial
Authors: Elliott Meghan J. , Fiest Kirsten M. , Love Shannan , Birdsell Dale , Loth Maureena , Dumka Heather , Rana Benny , Shommu Nusrat , Benterud Eleanor , Gil Sarah , Acharya Dilaram , Harrison Tyrone G. , Pannu Neesh , James Matthew T.
Published: August 2024

Key Points

For AKI prevention trial recruitment, patients prioritized technology enabled prescreening and involvement of family members in the consent process.

For trial intervention delivery, participants prioritized measures to facilitate ease of trial intervention administration and return visits.

For AKI prevention trial outcomes, patient participants identified effects on kidney-related and other clinical outcomes as top priorities.

Background

High-quality clinical trials are needed to establish the efficacy and safety of novel therapies for AKI prevention. In this consensus workshop, we identified patient and caregiver priorities for recruitment, intervention delivery, and outcomes of a clinical trial of cilastatin to prevent nephrotoxic AKI.

Methods

We included adults with lived experience of AKI, CKD, or risk factors of AKI (e.g., critical care hospitalization) and their caregivers. Using a modified nominal group technique approach, we conducted a series of hybrid in-person/virtual discussions covering three clinical trial topic areas: (1) consent and recruitment, (2) intervention delivery, and (3) trial outcomes. Participants voted on their top preferences in each topic area, and discussion transcripts were analyzed inductively using conventional content analysis.

Results

Thirteen individuals (11 patients, two caregivers) participated in the workshop. For consent and recruitment, participants prioritized technology enabled prescreening and involvement of family members in the consent process. For intervention delivery, participants prioritized measures to facilitate ease of intervention administration and return visits. For trial outcomes, participants identified kidney-related and other clinical outcomes (e.g., AKI, CKD, cardiovascular events) as top priorities. Analysis of transcripts provided insight into care team and family involvement in trial-related decisions, implications of allocation to a placebo arm, and impact of participants' experiences of AKI and critical illness.

Conclusions

Findings from our workshop will directly inform development of a clinical trial protocol of cilastatin for nephrotoxic AKI prevention and can assist others in patient-centered approaches to AKI trial design.
Exploring the role of AI in enhancing sustainability within New Zealand's hospitality industry: A study on knowledge, applicability, and perception in reducing food waste
Authors:   , Perera Melanie
Published: August 2024

The hospitality industry in New Zealand is a noteworthy contributor towards the country’s Gross Domestic Product, however, it is also responsible for a significant amount of food waste (FW). In recent years, there has been a growing interest globally in artificial intelligence (AI) to curb FW in the hospitality industry. This study explores the role of AI in reducing FW and enhancing sustainability within New Zealand's hospitality industry, specifically, it focuses on the factors critical for its implementation - knowledge, attitudes, and perceptions of hospitality stakeholders. The study adopted a mixed-methods approach involving quantitative and qualitative data collection from 131 industry professionals. The data suggests that the sample is skewed towards the lower end of FW, requiring caution due to inconsistent self-reported data with audits (Chisnall, 2017). A quarter were unsure or found it difficult to estimate avoidable food waste (AFW), potentially indicating a lack of awareness or difficulty measuring FW accurately. Inaccurate demand forecasting is the primary cause of FW in catering services and cafes/coffee shops, while portion control and plate waste are cited as the main causes of FW in fine-dining restaurants and pubs. A lack of FW awareness is the leading cause of FW in hotels/resorts and fast-food outlets. The diverse range of challenges faced by the hospitality industry provides insights into the areas where improvements can be made to increase efficiency, reduce waste, and enhance customer satisfaction. The study found a general lack of awareness and knowledge about AI among hospitality professionals, yet an openness to adopting AI-driven technologies for FW reduction. Challenges such as cost-effectiveness and proven effectiveness are key causes hindering AI adoption. Increased awareness and promotion of AI's return on investment could decrease scepticism and facilitate effective integration into FW reduction strategies. Finally, this research underlines the need for collaborative efforts among industry professionals, policymakers, and technology developers to overcome existing hurdles and leverage AI for sustainable practices in the hospitality sector in New Zealand.
“Kıspet Pehlivanın Yarısıdır” : Kültürel Miras Aktarımında Sinema Sanatından Yararlanma Örneği Olarak “Kıspet” Filmi
Authors: Özdemir Kadirhan
Published: August 2024

Kültür, sanat alanında kendine özgü kodlarla varlık gösterir. Sinema bu sanat dallarından biri olarak toplumun kültürel belleğinde yer etmiş semboller ve kavramlarla ilişkilendirilir. Yönetmenler ve senaristler, eserlerinde bu kültürel belleğe sıkça atıfta bulunurlar. Halk bilimi ile görsel kültürün bir parçası olan filmler arasındaki ilişki, bu kültürel kodlara yapılan atıflara dayanır. Makalede, kültürel mirasın aktarımında sinema sanatının rolü “Kıspet” adlı kısa film üzerinden incelenmektedir. Senaryosunu Necip Güleçer ve Harun Korkmaz’ın yazdığı ve yönetmenliğini Harun Korkmaz’ın üstlendiği “Kıspet” kısa filmi Kültür ve Turizm Bakanlığı Sinema Genel Müdürlüğü ile Yağlı Güreş Birliği tarafından desteklenmiştir. Filmin konusunu Antalya’nın bir köyünde yaşayan Hamza adında bir çocuğun başpehlivan olma hayali oluşturmaktadır. Çalışma kapsamında ele alınan film, taşıdığı kültürel unsurlar göz önünde bulundurularak kültürde tek tipleşmenin önüne geçmek üzere imzalanan Somut Olmayan Kültürel Mirasın Korunması Sözleşmesi bağlamında değerlendirilmiştir. Makalenin amacı, “Kıspet” adlı filmde kullanılan yağlı güreş geleneğine ilişkin kodların kültürel mirasın korunması ve gelecek nesillere aktarılması açısından nasıl bir rol oynadığını ortaya koymaktır. Bu çalışmada, yöntem olarak içerik analizi ve literatür taramasının yanı sıra, Harun Korkmaz’ın röportajları ve filmle ilgili haberler üzerinden netnografik analiz uygulanmıştır. Bulgular, “Kıspet” filminin Türk geleneksel yağlı güreş kültürünü sinema sanatı aracılığıyla başarılı bir şekilde işlediğini göstermektedir. Film, kültürel mirasın aktarımında iyi bir uygulamalı halk bilimi örneği olarak değerlendirilmektedir. “Kıspet” filmi, yağlı güreş etrafında oluşan geleneğin önemini vurgulayarak izleyicilerde kültürel mirasa olan bağlılığı artırırken, gelecek nesillere de bu mirası aktarma konusunda bir araç olarak işlev görmektedir. Bu bulgular, sinema sanatının kültürel mirasın korunması ve aktarılmasında önemli bir rol oynayabildiğini göstermektedir.
The Role and Positioning of Public Relations in Non Profit Organisations: A Case Study Analysis
Authors:   ,   Cork Institute of Technology, Lyons Gillian
Published: August 2024

"This study aims to explore the role and positioning of public relations (PR) in non-profit organisations (NPO’s). Two case studies are explored namely the Mercy Hospital Foundation and the Cork Simon Community. The lack of research in the area along with the belief that NPOs rely on PR more than any other industry prompted the research idea for this study. The literature review deals with the need for PR to be accepted as a management function with many leading theorists agreeing on the matter. According to Grunig (1992), the organisational effectiveness theories provide organisations with the formula to make their organisation successful. This study found that elements of the organisational theories had a direct link with the PR function through communication, strategic management planning, crisis management and goal evaluation. The research methodology was conducted through mainly qualitative research. The main research method for this study is two case studies in an attempt to explore depth rather than breadth. In order to maximise the research potential, sub research methods were utilised. Observation, documentation and record analysis along with interviews were used to gather data. The study found that neither organisation had a designed PR department yet relied heavily on the PR function. PR tasks were delegated between management and staff members. Despite this, the PR function was part of senior management and held in high regard by all interviewees. As a result of the findings, this study recommends a qualified and experienced PR professional is hired to maximise the PR function and allow other staff members concentrate on their own tasks. While the study explores NPOs it is intended to add to the body of PR knowledge across all sectors."
Safety Data Dissemination Framework For Vehicular Networks
Authors:   ,   Cork Institute of Technology, Koubek Martin
Published: August 2024

"An effective transportation system is essential to modern societies with transportation having a significant influence on economic growth, social development and the environment. But this dependence on road mobility has had serious consequences in terms of rising crash costs that include deaths, injuries, lost productivity, material damage and congestion. The European Union and many other governments worldwide support active safety as being the next logical step in diminishing crash costs after passive safety (safety belt, ABS etc.) where drivers will be warned prior to reaching hazardous situations enabling them to react appropriately. While improving road safety is unanimously considered the major driving factor for the deployment of Intelligent Vehicle Safety Systems, the challenges relating to reliable multi-hop broadcasting are exigent in vehicular networking. Broadcast protocols for Vehicular Ad-hoc Networks (VANET) must guarantee fast and reliable delivery of information to all vehicles in the neighbourhood, where the wireless communication medium is shared and highly unreliable with limited bandwidth. This thesis presents a broadcast communications protocol, the Reliable Vehicular Geobroadcast (RVG) protocol specifically designed for Vehicular Ad-hoc Networks (VANET) where the emphasis is on satisfying requirements for safety applications with respect to delay, packet delivery and overhead. The RVG protocol was compared with existing broadcast protocols in a complex realistic vehicular simulation environment including sample urban and highway test network scenarios using safety warning and SOS warning services to test the effectiveness of the protocols in disseminating warning messages. The evaluation results highlight that the existing broadcast protocols for vehicular safety application dissemination are not satisfactory for safety application requirements (packet delivery, delay and overhead) across a range of vehicular network environments. In contrast, the RVG protocol has been demonstrated to overcome these drawbacks - RVG is a robust broadcast protocol suitable as a general purpose dissemination mechanism for a range of safety applications over diverse vehicular environments in targeted geographical areas that satisfies safety data dissemination requirements with high packet delivery, low delay and low overhead."
Exploring Aspects Of Social Change In A Newly Multi-cultural Community
Authors:   ,   Institute of Technology Tralee, Hopkins Mary
Published: August 2024

"This research explored aspect of the social changes attached to the arrival of immigrants in a smaller-type rural community. It was particularly concerned with how this newly multicultural community was adapting to and accepting of a new social identity. This study may have provided the first opportunity for locals and new-comers to engage with the nature of changes happening in the community and to speak out on what they had to say. Qualitative in-depth interviews were conducted with 5 local population members, 5 adult immigrants and 2 support service staff. This research examined levels of cultural nationalism among local respondents, how the immigrant population regarded their position and identity in their new surroundings and how immigrant support workers saw their role as service providers. Results showed that, in spite of strong concerns with changes in the community, levels of racist thinking among local respondents were more associated with cultural nationalism than personal racist attitudes towards new-comers. However, recorded low efforts at integration and adoption of host country identity, indicate that immigrant respondents are likely to experience adaptational difficulties which can benefit from better bridging interventions. Discussion at each stage reflects on coping levels and the adaptive defenses being deployed while this community adjusts to new multicultural social structures."
The Role And Significance Placed On Corporate Social Responsibility In The Hotel Industry In The South West Region Of Ireland.
Authors:   ,   Cork Institute of Technology, Millar Shirley
Published: August 2024

"This research sets out to examine the concept of Corporate Social Responsibility in the context of the hotel industry, with a specific focus on Ireland and the South West Region. The study looked at the level of importance placed on CSR by both the hotel consumer and the hotel industry. The study also sought to determine the relevance of CSR as a source of competitive advantage Interest in the practice of Corporate Social Responsibility (CSR) has become increasingly prominent in recent years. There has been a shift in practice from companies doing good to be seen to be doing good, towards a more mutually beneficial position where CSR activity allows a company to do good and do well. In recent decades the theory of the triple bottom line was also introduced. This is where a company operates with consideration given to the social, environmental and economic impact of the business. The primary research was carried out in the South West region of Ireland. On site questionnaires were used to gather consumer data and semi-structured interviews were used to gather industry data from hotel managers. A number of key findings have resulted from this study. CSR has been widely researched in the context of industry in general. There is, however, a dearth of research from the hotel industry’s perspective, especially in Ireland. It is evident that the hotel consumer is becoming more conscious of social and environmental activities, however, price location and quality of service remain the most important factors when choosing a hotel to use. This research also found that there is a lack of communication by hotels of their social and environmental activities to their customers. This information would influence the customers’ perception of the hotel if it was known to them, and perhaps alter purchase behaviour. The main areas identified for gaining competitive advantage were the improvement of the businesses’ reputation, the attraction of a higher quality workforce and the reduction in the cost base."
Factors of Fiber Resistance of Russian Breeding Cotton to Epiphytic Microflora for Obtaining Environmental Friendly Raw Materials
Authors: Илларионова К.В. , Григорьев С.В.
Published: August 2024

Глобальная температура и влажность оказывают широкомасштабное воздействие на все сферы жизни. В благоприятных условиях текстиль является средой активности грибов и бактерий, подвергается биоразрушению, что ведет к распространению плесени и микробиотическим воспалениям. Селекция прядильных на биорезистентность волокна к деструкторам – один из аспектов решения проблем экологии, адаптации агроэкосистем к меняющемуся климату. Хлопковое сырье – основное в производстве одежды и бытового текстиля. Исследование факторов биоустойчивости волокна к гнилостному разрушению актуально для создания современного поколения сортов прядильно-масличных культур. Цель работы – изучение биологической деструкции волокна хлопчатника российской селекции, выращенного в Южном ФО РФ. Новизну исследований составляют полученные данные по устойчивости разноокрашенного хлопкового волокна к биоразрушению микрофлорой во взаимосвязи с термическим изменением его массы, что имеет принципиальное значение для создания экологичного текстиля в РФ. Исследовано зеленое, коричневое и белое волокно 9 сортов и линий хлопчатника. Рост микрофлоры на хлопке стимулирован при 28°С и влажности 90-98 %. Деструкцию волокна изучали световой микроскопией, температурную деградацию – на дериватографе Q-1000. Для изучения матрицы признаков использован анализ главных компонент (PCA). Установлено, что зеленое волокно более устойчиво к биодеструкции, чем белое. Наиболее устойчивым оказалось коричневое. Термостойкость хлопкового волокна в значительной мере определяется его исходной устойчивостью. Данные о признаках – компонентах резистентности волокна к биодеструкции во взаимосвязи с его натуральной окрашенностью – составляют научную ценность исследований. Исследования имеют практическую значимость, поскольку получение хлопкового волокна, обладающего естественной устойчивостью к гнилостному разрушению микроорганизмами, будет способствовать оптимизации химической нагрузки в производстве, улучшать агроэкологию среды, позволит повысить биобезопасность текстильных изделий.
THE ROLE OF NURSING IN BARRETT'S OESOPHAGUS: IDENTIFICATION, DIAGNOSIS AND TREATMENT.
Authors: Rubén Aced Magaña , Isabel Cólera Gómez , Ana María Morón Esteban , Ana Saide Gabro Marcén , Micaela Ardid Pardo , Teresa Peón Sánchez
Published: August 2024

El Esófago de Barrett (EB) es una condición médica originada por la transformación de la mucosa esofágica distal, donde las células escamosas normales son sustituidas por un epitelio columnar con células caliciformes. Esta modificación estructural puede predisponer al desarrollo de cáncer esofágico, por lo que su manejo adecuado es crucial. En este contexto, este estudio se enfoca en explorar el papel fundamental del personal de enfermería en todo el espectro del EB, desde el diagnóstico inicial hasta el tratamiento continuo. La revisión exhaustiva de la literatura incluyó bases de datos reconocidas como PubMed, Elsevier y Scielo, así como otras fuentes relevantes, para recopilar información actualizada y fundamentada. Los hallazgos subrayan diversas intervenciones clave donde el personal de enfermería desempeña un rol crucial. Entre estas intervenciones se destacan las medidas higiénico-dietéticas, que incluyen recomendaciones sobre la dieta y el control del reflujo gastroesofágico, factores cruciales en el manejo del EB. Además, se reconoce la importancia del manejo farmacológico, donde los enfermeros no solo administran medicamentos sino que también educan a los pacientes sobre su correcto uso y efectos secundarios. En casos más avanzados, el papel de la enfermería en la preparación y seguimiento de procedimientos quirúrgicos es esencial, asegurando una atención integral y continua. Un componente crucial que emerge de esta revisión es la educación para la salud proporcionada por el personal de enfermería. Esta educación abarca desde la promoción de estilos de vida saludables hasta la explicación detallada de la enfermedad y sus complicaciones potenciales, empoderando así a los pacientes para que tomen decisiones informadas sobre su salud. En resumen, la formación especializada y el rol activo del personal de enfermería son fundamentales para mejorar los resultados clínicos y la calidad de vida de los pacientes con EB. Su participación desde el diagnóstico inicial hasta el manejo continuo no solo optimiza la atención médica, sino que también brinda un apoyo invaluable tanto a pacientes como a sus familias durante todo el proceso de tratamiento de esta compleja condición médica.
THE ROLE OF NURSERY IN THE CARE OF EPILEPSY PATIENTS IN SPECIALIZED UNITS.
Authors: Ana Saide Gabro Marcén , Rubén Aced Magaña , Isabel Cólera Gómez , Ana María Morón Esteban , Teresa Peón Sánchez , Micaela Ardid Pardo
Published: August 2024

La epilepsia es una condición neurológica caracterizada por la hiperexcitabilidad de las neuronas, siendo una de las principales causas de consulta en neurología. Para atender a los pacientes con esta patología, se está estudiando la importancia de las unidades especializadas en epilepsia y el papel fundamental de la enfermería en el diagnóstico, tratamiento y educación de los pacientes y sus familias. Se destaca la necesidad de incrementar el número de estas unidades y la formación especializada en neurología para el personal de enfermería.
CLINICAL CASE: NURSING CARE PLAN FOR MYOMECTOMY.
Authors: Micaela Ardid Pardo , Rubén Aced Magaña , Isabel Cólera Gómez , Ana María Morón Esteban , Teresa Peón Sánchez , Ana Saide Gabro Marcén
Published: August 2024

Los miomas uterinos son tumores benignos que surgen en el miometrio. Actualmente, los miomas uterinos tienen una prevalencia del 25 al 40% en mujeres por debajo de los 50 años. Se presenta el caso clínico de una paciente de 30 años que se somete a una miomectomía, realizándose un Proceso de Atención de Enfermería (PAE) según la valoración de las necesidades de Virginia Henderson, determinándose los diagnósticos, objetivos e intervenciones, utilizando la nomenclatura NANDA, NOC Y NIC.
ERKƏN YAŞLI UŞAQLARDA KƏSKİN RESPİRATOR XƏSTƏLİKLƏR ZAMANI İL-21 VƏ γ-İNF SƏVİYYƏSİ
Authors: Hüseynova I.E. , Həsənov Ə.Q.
Published: August 2024

Məqalədə erkən yaşlı uşaqlarda tənəffüs yolları xəstəlikləri zamanı sitokin sistemində baş verən dəyişiklikləri öyrənmək məqsədilə aparılmış tədqiqat işi haqqında məlumat verilmişdir. Tədqiqata tənəffüs yollarının müxtəlif xəstəlikləri ilə ambulator və stasionar müalicə alan hər iki cinsdən olan 59 erkən yaşlı uşaq daxil edilmişdir. Kontrol qrup kimi 20 praktik sağlam uşaq götürülmüşdür. Əsas qrupa daxil olan xəstələr diaqnoza əsasən 2 yarımqrupa bölünmüşdür: I yarımqrupa kəskin respirator xəstəliyi (KRX) olan 37 xəstə, II yarımqrupa digər tənəffüs yolları xəstəlikləri olan 22 uşaq daxil edilmişdir. Tədqiqata cəlb olunmuş xəstə və sağlam uşaqlarda immun göstəricilər – qan serumunda ELİSA metodu ilə İL-21 konsentrasiyası, immunoferment analizi (İFA) metodu ilə γ-İNF konsentrasiyası təyini edilmişdir. Tədqiqat göstərmişdir ki, I yarımqrupda xəstələrin qan serumunda İL-21 konsentrasiyası kontrol qrupdakına nisbətən 2,2 dəfə, II yarımqrupda kontrol qrupdakına nisbətən 3,2 dəfə artır. γ-İNF konsentrasiyası I yarımqrupda kontrol qrupa nisbətən 1,9 dəfə artmış, II yarımqrupda isə 1,7 dəfə azalmışdır. Beləliklə, aparılan tədqiqatın nəticələrinə əsasən demək olar ki, erkən yaşlı uşaqlarda tənəffüs yolları xəstəliklərində İL-21 və γ-İNF klinik diaqnostik əhəmiyyət daşıya bilər. Açar sözlər: kəskin respirator xəstəliklər, immun sistem, sitokinlər
БРУКСИЗМ И СТОМАТОЛОГИЧЕСКИЙ СТАТУС ПАЦИЕНТОВ С ШИЗОФРЕНИЕЙ ПРИ РАЗНЫХ ВИДАХ МЕДИКАМЕНТОЗНОЙ ТЕРАПИИ
Authors: Бойко Д.И. , Евтушок В.В. , Скрыпников А.Н. , Сонник Г.Т. , Борисенко В.В. , Казаков А.А.
Published: August 2024

В ходе исследований были обследованы 51 пациент с клиническим диагнозом шизофрения, которые были разделены на 2 группы: 1 – пациенты, которые находились на лечении комбинацией нейролептическим и противоэпилептическим средством (16 человек); 2 – пациенты, которые принимали комбинацию двух нейролептиков (35 человек). Всем пациентам было проведено клиническое интервью с определением основных жалоб общего и стоматологического профиля, а также стоматологическое обследование с определением количества кариозных, пломбированных и удаленных зубов, упрощенного индекса Грина-Вермильйона и папиллярно-маргинально-альвеолярного индекса. Пациенты, получавшие лечение двумя нейролептическими средствами в сравнении с комбинацией нейролептик и антиконвульсант, имели худшее гигиеническое состояние полости рта, что может быть связано с нормотимическим эффектом антиконвульсантов. Выявлена связь формы медикаментозной терапии шизофрении с вероятностью развития бруксизма. Установлена вероятность развития брук116 сизма с большей частотой у пациентов, находящихся на лечении комбинацией нейролептиков с противоэпилептическими средствами. Построено прогностическую модель определения вероятности развития бруксизма у пациентов с шизофренией, получающих разное медикаментозное лечение.
GİCGAH-ÇƏNƏ OYNAĞININ OSTEOARTROZLARININ MÜALİCƏSİNDƏ XONDROKSİLİN TƏTBİQİ
Authors: Əhmədov E.T. , Cəfərov M.Ə. , Quliyev A.H. , Qurbanəliyeva Q.İ.
Published: August 2024

Məqalədə gicgah-çənə oynağının osteoartrozu olan xəstələrin müalicə kompleksinə xondroksil preparatının əlavə edilməsinin effektivliyi haqqında məlumat verilmişdir. 70 xəstə (50 qadın, 20 kişi) üzərində aparılmış müşahidələr göstərmişdir ki, xondroksil preparatı ilə müalicədən sonra gicgah-çənə oynağının hərəkətliliyi bərpa olunur, ağızın açılması və çənənin hərəkətliliyi yaxşılaşır, çeynəmə və nitq qabiliyyəti normallaşır. Müəlliflər müalicə kompleksinə əlavə edilən xondroksilin təsirindən sağalmanın sürətlənməsini və xəstələrin həyat keyfiyyətinin yaxşılaşmasını preparatın oynaqdaxili metabolizm proseslərinə tənzimedici təsiri ilə izah edirlər.
АНТИСИНТЕТАЗНЫЙ СИНДРОМ
Authors: Шамгунова Б.А. , Касымова Е.Б. , Бегляров Р.О. , Заклякова Л.В.
Published: August 2024

Антисинтетазный синдром – это редкое аутоиммунное заболевание, ассоциированное с воспалительной миопатией, артритом, интерстициальным заболеванием легких, лихорадкой, феноменом Рейно и рукой механика. Антисинтетазный синдром связан с выработкой антисинтетазных антител, которые участвуют в патогенезе мышечного и легочного повреждения; их наличие коррелируют с активностью заболевания. В обзорной статье представлены новейшие данные об эпидемиологии, патогенезе, клинических проявлениях и лечении этого редкого ревматического заболевания.
ALKOHOLUN UZUN MÜDDƏT TƏSİRİ NƏTİCƏSİNDƏ AĞ SİÇOVULLARIN BAŞ BEYNİ STRUKTURLARINDA MONOAMİNLƏRİN MİQDARİ DƏYİŞİKLİKLƏRİNİN KORREKSİYASI
Authors: Мамедгасанов Т.С.
Published: August 2024

Представлены результаты исследования, проведенного с целью фармакологического изучения возможности корригирующего действия мексидола и пирацетама на изменение количества моноаминов в разных структурах головного мозга белых крыс при длительном воздействии алкоголя. Анализ результатов проведенных исследований показал, что изменение количества моноаминов в разных структурах головного мозга белых крыс (гипоталамус, стриатум, лобная кора) при длительном применении алкоголя приближается к исходному уровню под влиянием мексидола и пирацетама. Более быстрая нормализация содержания моноаминов наблюдалась при совместном применении мексидола и пирацетама.

Məqalədə xronik alkohol qəbulu fonunda ağ siçovullarda baş beyninin müxtəlif strukturlarında monoaminlərin miqdarında baş verən dəyişikliklərə meksidol və pirasetamın korrektor təsirinin farmakoloji tədqiqinə həsr edilmiş tədqiqat işi haqqında məlumat verilmişdir. Tədqiqatın nəticələrinin təhlili göstərmişdir ki, meksidol və pirasetamın təyini fonunda xronik alkohol qəbulu ilə bağlı ağ siçovulların baş beyninin müxtəlif strukturlarında (hipotalamus, striatum, frontal qabıq) monoaminlərin miqdar dəyişikliklərini əhəmiyyətli dərəcədə aradan qaldırır. Ən yaxşı effekt meksidol və pirasetamın birlikdə istifadəsi zamanı müşahidə edilir.

The article provides information about a pharmacological research study dedicated to changes in the levels of monoamines in the white matter of the brain during chronic alcohol consumption. This study focused on the corrective effects of “Mexidol” and “Piracetam”. The analysis of the research findings showed that the changes in the levels of monoamines in different brain structures of white rats (hypothalamus, striatum, frontal cortex) during prolonged alcohol consumption approach the initial levels under the influence of “Mexidol” and “Piracetam”. A faster normalization of monoamine content was observed with the simultaneous administration of “Mexidol” and “Piracetam”.
CANDLE-ПОДОБНЫЙ СИНДРОМ: КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ
Authors: Quliyeva N.M.
Published: August 2024

Məqalədə nadir patologiyalardan biri olan CANDLE sindromuna (Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated temperature) görə müalicə almış 1 yaş 5 aylıq xəstə qız haqqında məlumat verilir. Xəstə kompleks klinik, immunoloji laborator, instrumental müayinələrdən keçirilmiş, genetik analiz olaraq PSMB4, PSMB8, PSMB9 və PSMA3 genləri araşdırılsa da, bu genlər aşkar olunmayıb, lakin bütün klinik əlamətlərə və xəstəliyin gedişinə əsasən Candle sindromuna bənzədiyinə görə, xəstəyə CANDLE-yə bənzər sindrom diaqnozu qoyulmuşdur. Məqalədə qeyri-spesifik immun mexanizm vasitəsilə, bəzi hallarda isə spesifik immun tənzimin pozulması nəticəsində yaranan və autosom-ressesiv yolla ötürülən CANDLE sindromu haqqında qısa məlumatla yanaşı, müəllifin praktikada müşahidə etdiyi klinik nümunənin şərhi verilmişdir. Bu xəstəliyin tədqiqi klinik əlamətlərinin tipik xüsusiyyətlərinə, diaqnostika və müalicəsinin çətinliyinə görə böyük praktik əhəmiyyət kəsb edir.

В статье представлены сведения о девочке 1 года 5 месяцев с одной из редких патологий – CANDLE-подобным синдромом (хронический атипичный нейтрофильный дерматоз с липодистрофией и повышенной температурой). Больному проведено комплексное клинико-иммунологическое лабораторное и инструментальное обследование, в качестве генетического анализа исследованы гены PSMB4, PSMB8, PSMB9 и PSMA3, но эти гены не обнаружены, однако учитывая, что все клинические признаки и течение заболевания сходны CANDLE-синдромом, у больной установлен диагноз CANDLE-подобный синдром. В статье наряду с краткими сведениями о синдроме CANDLE, который обусловлен неспецифическим иммунным механизмом, а при некоторых случаях как следствие специфического нарушения иммунной регуляции и передается по аутосомно-рецессивному пути, приведен пример, наблюдаемый в практике автора. Изучение этого заболевания имеет большое практическое значение в связи с типичными особенностями его клинической симптоматики, сложностью диагностики и лечения.

The article provides information about a 1-year and 5-month-old girl with one of the rare pathologies – CANDLE-like syndrome (Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature). The patient underwent a comprehensive clinical-immunological laboratory and instrumental examination. Genetic analysis of the PSMB4, PSMB8, PSMB9, and PSMA3 genes was conducted, but these genes were not detected. However, considering that all clinical signs and the course of the disease are similar to CANDLE syndrome, the patient was diagnosed with CANDLE-like syndrome. The article briefly outlines information about CANDLE syndrome, which is caused by a non-specific immune mechanism and, in some cases, as a result of a specific immune regulation disorder, transmitted in an autosomal recessive manner. Alongside this, the article presents a case observed in the author's practice. The study of this disease is of great practical importance due to the typical features of its clinical symptoms, the complexity of diagnosis, and treatment.
КЛИНИКО-АНАМНЕСТИЧЕСКАЯ ХАРАКТЕРИСТИКА ОСТРОЙ КРАПИВНИЦЫ У ДЕТЕЙ И УРОВЕНЬ СЕКРЕТОРНОГО IgA В ПОЛОСТИ РТА БОЛЬНЫХ
Authors: Şixəmmədova A.C.
Published: August 2024

Məqalədə kəskin övrə diaqnozu qoyulmuş uşaqların klinik anamnestik xüsusiyyətlərinin öyrənilməsi və bu xəstəlik zamanı ağız boşluğunda sekretor IgA səviyyəsinin araşdırılması məqsədilə aparılmış tədqiqat işi haqqında məlumat verilir. Əsas tədqiqat qrupuna kəskin övrə diaqnozu qoyulmuş 80 uşaq, kontrol qrupa isə 20 praktik sağlam uşaq daxil edilmişdir . Tədqiqata cəlb edilmiş xəstə və sağlam uşaqların ağız suyundakı SIgA (sekretor IgA) – immunofermet analizi ( İFA) metodu ilə Medispec-6000 aparatında təyin edilmişdir. Tədqiqat göstərmişdir ki, kəskin övrə xəstəliyi diaqnozu ilə tədqiqata cəlb edilmiş uşaqlar arasında yaşı 3-dən 6-ya qədər olanlar üstünlük təşkil edirlər – 42 nəfər (52,5%). Etioloji amillər arasında qida allergenlərinin rolu daha böyükdür. Xəstələrin ağız boşluğunda SIgA səviyyəsi kontrol qrupdakına nisbətən 1,3 dəfə aşağı olmuşdur.

В статье представлены данные по изучению клинико-анамнестической характеристики детей с диагнозом острая крапивница, а также исследованию уровня секреторного IgA в полости рта при этом заболевании. В основную группу исследования вошли 80 детей с диагнозом острая крапивница, в группу контроля — 20 практически здоровых детей. SIgA (секреторный IgA) в слюне больных и здоровых детей, участвующих в исследовании, определяли методом иммуноферментного анализа (ИФА) на аппарате Medispec-6000. Исследование показало, что среди включенных в исследование детей с диагнозом острая крапивница преобладали пациенты в возрасте от 3 до 6 лет - 42 ребенка (52,5%). Среди этиологических факторов преобладали пищевые аллергены. Уровень SIgA в полости рта больных был в 1,3 раза ниже, чем в контрольной группе.

The article presents data from a study on the clinical and anamnestic characteristics of children with acute urticaria, as well as the examination of secretory IgA levels in the oral cavity. The main study group comprised 80 children diagnosed with acute urticaria, while the control group consisted of 20 practically healthy children. Secretory IgA (SIgA) in the saliva of both sick and healthy children participating in the study was determined using enzyme-linked immunosorbent assay (ELISA) with the Medispec-6000 apparatus. The study revealed that among the children with acute urticaria included in the study, those aged 3 to 6 years predominated, comprising 42 children (52.5%). Food allergens were predominant among the etiological factors. The level of SIgA in the oral cavity of patients was 1.3 times lower than that in the control group.
Implementation of the principle of presumption of innocence of suspects in investigations, pre-trial and trial examinations
Authors: Sukadana Dewa Ayu Putri
Published: August 2024

The principle of presumption of innocence is a fundamental legal principle in the justice system to protect the rights of suspects. Law No. 8 of 1981 concerning Criminal Procedure Law (KUHAP) Article 66 of the Criminal Procedure Code explains "every person suspected of committing a criminal act is deemed innocent, until a court decision is made that has permanent legal force." This means that as long as the decision has not been changed, the defendant or suspect cannot be blamed. The application of the principle of presumption of innocence has become the main basis in the modern justice system to guarantee justice and protect individual rights. This article explores the significance and implementation of the presumption of innocence in the context of protecting the rights of suspects in the justice system. Through an overview of the literature and context analysis, this article outlines the basic principles of the principle of presumption that brings truth and its influence on the process of examining disputes. Apart from that, this article also discusses the challenges and efforts to ensure the effective implementation of the principle of presumption of illegality in legal practice.
Legal ethics for tracing the roots of corruption in Indonesia
Authors: Hehanussa Deassy JA , Pede Albert
Published: August 2024

The purpose of this study is to investigate how the principles of legal ethics may be used to find and eliminate the sources of corruption in Indonesia. Legal ethics provides a framework for evaluating legal acts and regulations in light of their ethical implications by incorporating moral principles within the legal profession. Legal statutes, administrative rules, judicial rulings, and scholarly articles are the main and secondary sources consulted in this normative qualitative study. To conduct a normative analysis, one must first determine the efficacy of the current legal framework in eliminating corrupt activities, and then assess the application of legal ethical standards within that framework. According to the findings, flaws in the legal system that permit corruption may be identified by using ethical principles of law, such as fairness, honesty, accountability, and respect for human rights. Justice requires that the law be applied without bias or prejudice, and integrity guarantees that everyone participating in the judicial system is forthright and honest. The public's faith in the justice system depends on its honest administration, and the public may rest certain that its representatives will always put the public interest first because of their moral and professional obligations. Human rights compliance guarantees that anti-corruption initiatives safeguard victims' rights while also punishing those responsible for wrongdoing
Consumer Protection Againts Innappropriate Online Goods Purchases Reviewed From The Civil Code and Consumer Protection Law
Authors: Turnip Johannes Mangapul , Amalia Apri
Published: August 2024

Online buying and selling transactions are carried out by some Indonesian people through e-commerce platform whice are a technological development. Online purchasing transactions are carried out to save time and make things easier for buyers. However, there is a phenomenon in online purchases in the form of consumer complaints regarding dissatisfaction with the goods purchased which do not match  the information provided by the seller. The identification of the research problem is how consume law is protected in the civil code and consumer protection law and the responsibility of business actors for consumer losses. The aim of the research is to determine consumer legal protection and the responsibilities of business actors towards consumers. The research uses normative juridical research, a statutory regulation approach and is analysed qualitatively. Consumer protection is regulated in the civil code and consumer protection law number 8 of 1999 which regulates the protection and replacement of goods if the goods received by the consumer do not conform to what was agreed in the sale and purchase transaction. The responbility of business actors for consumer losses is to provide compensation for demage, replacement of goods and/or refunds
Normative Legal Analysis of Notary Code of Ethics: Improving Legal Professional Ethical Standards
Authors: Prasetyo Wakhid
Published: August 2024

The notary profession plays a critical role in a country's legal system, requiring notaries to adhere to the highest ethical standards to maintain integrity, professionalism, and public trust. This research aims to analyze the gap between the existing notary code of ethics and the expected ethical standards. Using a normative legal approach, the study examines primary legal materials, including statutory regulations, ethical guidelines, and relevant court decisions, as well as secondary legal sources. The research findings reveal several gaps between the current notary code of ethics and the anticipated ethical standards. One significant gap is the lack of firm regulations addressing potential conflicts of interest that may arise in notarial practice. Additionally, the study identified differences in the enforcement of ethical sanctions and complaint mechanisms for code of ethics violations. These findings underscore the importance of strengthening the notary code of ethics to ensure alignment with the profession's expected ethical standards. By addressing these gaps, the notary profession can further enhance its integrity, professionalism, and the public's trust in the legal system. The study's insights can inform policymakers and regulatory bodies in their efforts to refine and reinforce the ethical framework governing the notary profession