bluuebunny/crossref_metadata_2025 huggingface dataset:
КОММУНИКАТИВНО-ПРАГМАТИЧЕСКОЕ ОПИСАНИЕ ОБРАЩЕНИЙ К НЕЗНАКОМОМУ АДРЕСАТУ В РУССКОЙ И ТУРЕЦКОЙ ЛИНГВОКУЛЬТУРАХ
Authors: Янкын Н.В.
Published: October 2024

Данная статья посвящена анализу функционирования формул обращений к незнакомым людям в ситуации привлечения внимания в русском и турецком языках с целью выявления особенностей их употребления. Коммуникативно - прагматическое описание представляет собой взаимодействие методик, используемых для изучения употребления говорящими языка в процессе коммуникации. Основная функция обращений - установление контакта для последующей коммуникации. Выбор нужной формы обращения регулирует взаимоотношения между говорящими, ведёт к успешному диалогу культур. Теория и методика преподавания иностранных языков, в том числе и русского как иностранного, нуждается в сопоставительных исследованиях для полного изучения особенностей функционирования речевых единиц. Результат данного исследования будет полезен как для студентов, изучающих русский и турецкий языки, так и для преподавателей с целью предупреждения интерференции.

The present paper is concerned with the analysis of the functioning of the formulas of addresses to strangers in a situation of attracting attention in Russian and Turkish in order to identify the peculiarities of their use. Communicative-pragmatic description is an interaction of techniques used to study the use of the language by speakers in the process of communication. The main function of addresses is to establish contact for further communication. The choice of the right form of address determines the relationship between the speakers and leads to a successful dialogue of cultures. The theory and methodology of teaching foreign languages, including Russian as a foreign language, needs comparative research to fully study the peculiarities of speech units' functioning. The result of this study will be useful for both Russian and Turkish language students and teachers to prevent possible interference.

Макала орус жана түрк тилдеринде көңүл буруу максатында бейтааныш адамдарга кайрылуу формулаларынын иштешин талдоого жана аларды колдонуунун өзгөчөлүктөрүн аныктоого арналган. Коммуникативдик-прагматикалык сыпаттоо - сүйлөшүү процессинде сүйлөшүп жаткандардын тилди колдонуусун изилдөө үчүн колдонулуучу ыкмалардын өз ара аракети. Кайрылуунун негизги милдети - коммуникацияны улантуу үчүн мамиле түзүп, кепти баштоо. Кайрылуунун керектүү формасын тандоо сүйлөөчүлөрдүн ортосундагы өз ара мамилелерди жөнгө салат, маданияттардын ийгиликтүү диалогуна алып келет. Чет тилдерди, анын ичинде орус тилин чет тили катары окутуунун теориясы жана методикасы сүйлөө бирдиктеринин иштешинин өзгөчөлүктөрүн толук изилдөө үчүн салыштырма изилдөөлөргө муктаж. Бул изилдөөнүн жыйынтыгы орус жана түрк тилдерин үйрөнүп жаткан студенттер үчүн да, мугалимдер үчүн да интерференцияны алдын алуу үчүн пайдалуу болот.
ПОНЯТИЕ И ВИДЫ ЭКВИВАЛЕНТНОСТИ В ГРАЖДАНСКОМ ПРАВЕ
Authors: Колсариева Н.Ш. , Самиев Д.М.
Published: October 2024

Статья посвящена вопросам эквивалентности в гражданском праве. Автором определены объект, цели и задачи исследования. Также им предприняты попытки изучения конкретных случаев применения принципа эквивалентности в гражданском праве. В статье приведены конкретные случаи применения эквивалентности, такие как возмещение морального вреда и неимущественного ущерба. Статья посвящена проблеме соизмеримости нанесённого ущерба и размера его возмещения, как и многие цивилисты автор придерживается позиции эквивалентности и его применение только в области гражданского права. Автор считает, что нельзя переводить неимущественные блага в материальную форму, в то же время он считает правонарушение не должно оставаться безнаказанным и предлагает тщательно изучить данную проблему и разработать другие варианты возмещения морального ущерба и неимущественного вреда.

Макала жарандык укуктагы эквиваленттүүлүктүн кѳйгѳйлѳрүнѳ арналган. Автор тарабынан изилдѳѳнүн объектисин, максатын жана милдеттерин аныкталган. Автор жарандык укуктагы эквиваленттүүлүк принцибин колдонуунун конкреттүү убакыттарын изилдѳѳ аракеттерин жасаган. Макалада эквиваленттүүлүктү колдонуунун конкреттүү учурлары, башкача айтканда моралдык, мүлктүк эмес зыянды калыбына келтирүү белгиленген. Макала келтирилген зыяндын жана аны калыбына келтирүү ѳлчѳмүнүн теңдигине, автор башка цивилистер катары эле эквиваленттүүлүк жарандык укукта гана пайдаланууну колдоосуна арналган. Автор мүлктүк эмес баалуулуктарды материалдык формага айлантырууга, ошол эле учурда укук бузуулар жазасыз калышына каршы экендигине байланыштуу бул кѳйгѳйдү терең изилдеп мүлктүк эмес жана моралдык зыянды калыбына келтирүүнүн башка жолдорун иштеп чыгуунун сунуштайт.

The article is devoted to the issues of equivalence in civil law. The author defined the object, goals and objectives of the study. He also attempted to study specific cases of application of the principle of equivalence in civil law. The article presents concrete cases of application of equivalence, such as compensation for moral damage and non-property damage. The article is devoted to the problem of commensurability of the inflicted damage and the size of its compensation. Like many civil lawyers, the author holds the position of equivalence and its application only in the civil law sphere. The author considers that it is impossible to transfer non-property benefits in a material form, at the same time he believes that the offense should not remain unpunished. The author proposes to study the problem carefully and develop other options of compensation for moral damage and non-property harm.
«МАНАС» ЭПОСУНДАГЫ «КАЛК КАРЫЯЛАРЫНЫН» ИДЕАЛЫ
Authors: Баитова Ф.Т. , Идаева А.Б.
Published: October 2024

Коомдун, мамлекеттин бакубаттыгы адамдардын пейилинен, көз карашынан, жүрүм-турумунан көз каранды экендиги байыртан келе жаткан акыйкат. Кыргыз элинин оозеки чыгармачылыгынын туу чокусу болгон «Манас» эпосун эле алсак, байыркы кыргыз коомунун абалы Жакыптын, Манастын, Абыке, Көбөштөрдүн адамдык ариетине жараша айырмалуу болгон. Эпостогу элдик наркты алып жүргөн даанышман таалимчилер Бакай, Кошой, Акбалталардан ала турган тарбия арбын. Алар жалпы журтту биримдикке чакырып, муундар байланышынын сакталуусу үчүн жаш муундарга жол көргөзүп, адал эмгекке үйрөткөн, көрөгөч, гуманист, акылман тарбиячы катары өз өрнөгү менен идеал деп таанылган. Өрнөктүү калк карылары жашоону уланткан кийинки муундарга үлгү болушкан жана алар жок учурда кыргыздырдын акыл көрөӊгөсү, нарк насили жокко тете болгон. Калк карыларынын эӊ негизги озуйпаларынын бири - сырткы баскынчылардан элди коргоо, элдин ынтымагын, биримдигин сактоо, эл-журттун, карапайым калктын жакшы жашоосу үчүн күрөшү болгон.

Издревле известно, что благополучие общества и страны зависит от поведения, взглядов и мировоззрения каждого человека. К примеру, благополучие древнего кыргызского общества отличалось человеческой честью таких главных героев, как Жакып, Манас, Абыке и Кобош в эпосе «Манас», который ценится как наивысшая точка устного произведения кыргызского народа. Эпос богат воспитаниями, которым можно научиться у Бакая, Кошоя и Акбалты, мудрых учителей, носителей-идеалов национальной ценности. Они - идеальные мастера, мудрые воспитатели-гуманисты, которые призывали к единству, направляли подрастающее поколение на правильный путь для сохранения связи между поколениями и на своем примере учили честному труду. Эти идеалы служили примером для подражания молодого поколения, а их отсутствие приравнивалось к отсутствию разума всего народа. Одной из их важнейших задач это - защитить народ от захватчиков, обеспечивать внутреннюю гармонию и единство и обеспечить хорошую жизнь нации.

It is known from ancient times that the well-being of society and the country depends on the attitudes, views and behavior of its each member. For instance, the state of the ancient Kyrgyz society was notable for the humane conscience of main heroes like Jakyp, Manas, Abyke and Kobosh in the epic “Manas”, which is considered to be the most successful and powerful folklore of the Kyrgyz nation. In the epic there is a great deal of lessons that can be learned from Bakai, Koshoi, and Akbalta, the wise teachers, the ideal holders of national value. They are evaluated as ideal masters, wise and humanistic educators, because they called for unity, set the pace for Kyrgyz youth to maintain the generational communication and taught to make an honest living through representing their role-model. These ideals served as a model for the young generation and their absence was evaluated as the absence of wit of the whole nation. One of their critical missions was to protect people from invaders; ensure a harmony and unity among people; and provide good living of the nation.
ТҮНДҮК АЛАЙ ТОО КЫРКАЛАРЫНДАГЫ ТИГИЛГЕН ТОКОЙЛОРДУН САНИТАРДЫК АБАЛЫ
Authors: Омурзакова Г.Т. , Абдижапар к.А.
Published: October 2024

Кыргызстанда жылдан жылга токой плантацияларын түзүү жана баалуулугу төмөн плантацияларды реконструкциялоо боюнча иштердин көлөмү өсүүдө. Ошондой эле тез өсүүчү дарактардын жана бадалдардын экономикалык жактан баалуулугу менен аны камсыз кылууга жөндөмдүү жаңы түрлөрүн тандоо аларды өстүрүү боюнча изилдөөлөрдүн көлөмү жогору болуп жатат. Булардын баары ийгиликтүү жаңылоо менен бирге бийик тоолуу токойлордун продуктуулугун жогорулатууда республиканын түштүк аймагындагы, негизинен Түркстан-Алай жана Фергана тоо кыркаларынын капталдарында, 1800-3000м абсолюттук бийиктикте таралган арча токоюнун алкагы күчөгөн антропогендик таасирге дуушар болуп, акырында токойлордун кыскарышына алып келген. Мамлекеттик токой фондунун сандык материалдары, Түркстан-Алай тоо кыркаларындагы арча токойлорунун абалы жөнүндө маалымат булактарына караганда, азыркы күндөгү антропогендик таасирдин натыйжасында токой аянттарынын кескин кыскарып кеткени ачык көрүнүп турат. Жалпысынан, бул тигилген токойлордо зыянкечтер жана илдеттер ар бир түргө мүнөздүү ооруулар менен жабыркаганы байкалган.

Из года в год в Кыргызстане растет объём работ по созданию лесных культур и реконструкции малоценных насаждений исследований по отбору и выращиванию новых пород деревьев и кустарников - быстрорастущих, хозяйственно ценных, способных обеспечить успешное возобновление, повышение продуктивности высокогорных лесов. Пояс арчовых лесов в южном регионе Республики, распространенный в основном по склонам Туркестане-Алайского и Ферганского хребта, на абсолютной высоте 1800-3000 м подвергается усиленному антропогенному воздействию, что в конечном счете, привело к сокращению лесопокрытых площадей. По числовым материалам Государственного лесного фонда, источникам информации о состоянии арчовых лесов Туркестано-Алая, видно, что площади лесов резко сократились в результате антропогенного воздействия современности. В целом было замечено, что эти лесонасаждения поражались вредителями и болезнями, характерными для каждого вида этого региона.

The volume of work on the creation of forest plantations and the reconstruction of low-value plantations is increasing from year in Kyrgyzstan. There is also an increasing and shrubs that can provide economic value. All this will increase the productivity of highland forests along with successful regeneration. The belt juniper forests in the southern region of the republic distributed mainly along the slopes of the Turkestan-Alai and Fergana ranges at an absolute height of 1800-3000m. It is subjected to increased anthropogenic impact which ultimately led to a reduction in forested areas. According to the numerical materials of the State Forestry Fund, sources of information about the state of juniper forests in the Turkestan-Alai mountain ranges is clear that the forest areas have been sharply reduced as a result of the anthropogenic influence of the present day. In general, it was observed that these planted forests were affected by pests and diseases with the specific to each species.
ANALYSIS OF GLOBAL EXPONENTIAL STABILITY FOR NONLINEAR IMPULSIVE STOCHASTIC SYSTEMS WITH DELAY USING REGULARIZATION TECHNIQUES
Authors: R. KADIEV  , A. PONOSOV
Published: October 2024

The W-transform in the form of the regularization techniques, based on inverse-positive matrices, is used to obtain verifiable global stability conditions for linear and nonlinear stochastic delay systems with random coefficients and impulses at random times. The results are conveniently formulated in terms of coefficients of the systems. Several examples illustrating the main results are offered.
EXISTENCE OF POSITIVE SOLUTIONS OF NONLINEAR STURM-LIOUVILLE BOUNDARY VALUE PROBLEMS
Authors: S. PANIGRAHI  , S. ROUT
Published: October 2024

The authors study the existence of positive solutions of nonlinear Sturm- Liouville boundary value problem: (p(t)y’ (t))’+ λf(t, y(t)) = 0, 0 < t < 1 with mixed boundary conditions ay(0) − bp(0)y'(0) = 0, cy(1) + dp(1)y'(1) = 0, for λ > 0 on a suitable interval. The methods involve the applications of a fixed point theorem for operators on a cone in a Banach space. An attempt has been made to establish the existence of a positive solutions of the above boundary value problem under certain sufficient conditions on f(t, y). Examples are given at the end of the paper to justify our results.
Social Mobility in Yeshiva High Schools in the 1980s: The Importance of Habitus and Religious Zionist Socialization
Authors: Trabelcy Erez
Published: October 2024

This article addresses the mobile experience of Mizrahi graduates of yeshiva high schools in the late 1980s. The research findings showed that the graduates attributed a central role to yeshiva high school in their process of social mobility. The yeshiva high school functioned as an elite educational institution and assisted students in the cultivation of a habitus that enabled social mobility. In addition, the students also experienced “sectoral mobility” as a result of their studies; their time in yeshiva high school was key to their integration into Israeli religious Zionist society. In conclusion, the study emphasizes the importance of habitus as a condition for mobility, with a particular focus on the religious Zionist socialization processes that took place in yeshiva high school in the 1980s.
Student Expectations in Hebrew Teacher Training: On the First Cohort of Palestinian Female Students from East Jerusalem
Authors: Manor Rama , Masry-Herzallah Asmahan
Published: October 2024

The study focused on the first cohort of Palestinian female students from East Jerusalem to enroll in a “Hebrew for Arabic speakers” teacher training program at the Hebrew University in Jerusalem. This novel curriculum is designed for Hebrew teachers in Arab schools, particularly in East Jerusalem. The research examined the students’ expectations from the curriculum and instructional staff. The study’s main argument was that students’ expectations from the program were impacted by a variety of historical, sociocultural, and political factors specific to the context of Jerusalem, as was their ability to become Hebrew teachers in East Jerusalem schools in accordance with the Israeli curriculum. Analysis according to Bronfenbrenner’s Ecological Theory indicated that students’ expectations pertained to: the development of personal and professional identity; the need for lecture support on academic and occupational issues; command of the Hebrew language as a stimulus for academic, occupational, and social development; integration in the Jerusalem employment market; and social mobility. The findings contribute to the little existing research on Palestinian Jerusalemites’ academic integration by conceptualizing a minority population’s aspirations in Israeli higher education. In this way, they may help policymakers in Israeli academic institutions to develop training programs targeted at specific populations.
Singlets-Driven Photoredox Catalysts: Transforming Noncatalytic Red Fluorophores to Efficient Catalysts
Authors: Abuhadba Sara , Fuqua Charlotte , Maltese Anthony , Schwinn Caroline , Lin Neo , Chen Angela , Martzloff Rilee , Esipova Tatiana , Mani Tomoyasu
Published: October 2024

Red-light absorbing photoredox catalysts offer potential advantages for large-scale reactions, expanding the range of usable substrates and facilitating bio-orthogonal applications. While many red-light absorbing/emitting fluorophores have been developed recently, functional red-light absorbing photoredox catalysts are scarce. Many photoredox catalysts rely on long-lived triplet excited states (triplets), which can efficiently engage in single electron transfer (SET) reactions with substrates. However, triplets of π-conjugated molecules are often significantly lower in energy than photogenerated singlet excited states (singlets). Combined with the inherent low energy of red light, this could limit the reductive/oxidative powers. Here, we introduce a series of sustainable heavy atom–free photoredox catalysts based on red-light absorbing dibenzo-fused BODIPY. The catalysts consist of two covalently linked units: a dibenzo-fused BODIPY fluorophore and an electron donor, arranged orthogonally. Excitation of the dibenzoBODIPY unit induces charge separation (CS) from the donor to the dibenzoBODIPY unit, forming a radical pair (RP) state. Unlike the regular BODIPY counterparts, these catalysts do not form triplets. Instead, SET occurs from the high-energy singlet-born RP states, preventing energy loss and effectively utilizing the low-energy red light. The proximity of donor molecules allows efficient charge separation despite the CS being uphill in energy. The molecules demonstrate efficient catalysis of Atom Transfer Radical Addition (ATRA) reaction, yielding products with high yields ranging from 70% to 90%, while the molecule without a donor group does not exhibit catalytic activity. The mechanistic studies by transient absorption and electron paramagnetic resonance (EPR) spectroscopy methods support the proposed mechanism. The study presents a new molecular design strategy for converting noncatalytic fluorophores to efficient photoredox catalysts operating in the red spectral region.
Transparent, ferroelectric Ca:HfO2 and Sr:HfO2 films grown from chemical solution on ITO-coated glass
Authors: Badillo-Avila Miguel-Angel , Taleb Sepide , Carreño-Jiménez Brenda , Ferreyra Cristian , Mokabber Taraneh , Rubi Diego , Aguirre Myriam , Castanedo-Pérez Rebeca , Torres-Delgado Gerardo , Acuautla Mónica , Noheda Beatriz
Published: October 2024

The discovery of ferroelectricity in HfO2 thin films has revived the interest on ferroelectric-based memories. Yet, other applications like transparent micro sensors and actuators are also potentially possible. By using a simple chemical solution method, we achieved the growth of transparent Ca:HfO2 and Sr:HfO2 films on ITO coated glass and reached polarization values of 12 and 6 µC/cm2, respectively, after deposition of top Pt electrodes. The selection of Ca or Sr as doping element brought about large variations in thermal conditions at which ferroelectricity in doped-HfO2 films was achieved. Sr:HfO2 required significantly shorter annealing times than Ca:HfO2 and caused deformation of the glass substrate despite otherwise equal processing conditions. Moreover, although, both Ca and Sr induced the crystallization of hafnia into high symmetry phases, the latter also enhanced the appearance of the monoclinic structure. Interestingly, high resolution transmission microscopy revealed a semi-epitaxial “cube on cube” growth of doped-HfO2 on individual ITO crystals. This predicts that accomplishing fully epitaxial HfO2 films by a chemical solution method should be possible. Technological innovation might come from achieving fully transparent ferroelectric/piezoelectric HfO2-based devices.
The effect of pyridinecarboxaldehyde functionalisation on reactivity and N-terminal protein modification
Authors: Barber Lydia , Spicer Christopher
Published: October 2024

The site-selective modification of protein N-termini represents a powerful strategy for producing homogeneous bioconjugates. 2-Pyridinecarboxaldehydes have emerged as a leading reagent class in this area, but conjugation suffers from relatively slow rates and a degree of reversibility. In this work, we therefore studied the effects of pyridinecarboxaldehyde functionalisation on N-terminal modification, providing insight into the factors governing relative contributions from competing reaction pathways and design criteria for second generation reagents for protein labelling. Importantly, this insight allowed us to identify several candidate reagents which provide both accelerated and more stable protein labelling, enabling further applications of this powerful technology.
A versatile and high-resolution hydrogel platform for volumetric additive manufacturing based on poly(ethylene glycol) diacrylate and alginate blends
Authors: Hall Patrick , Chasko DeShea , Wheeler Tim , Ostojich Diana , Aptecker Judah , Liashenko Ievgenii , Luxenhofer Robert , Lindberg Gabriella , Dalton Paul
Published: October 2024

Volumetric additive manufacturing (VAM) has emerged as a potent method for fabricating complex structures out of soft materials such as hydrogels. In this study, we developed a low-cost photopolymer platform based on low molecular weight poly (ethylene glycol) diacrylate (PEGDA) and alginate (Alg) blends which reduces material costs ~1000x. By adding non-crosslinked 0.5 wt.% of Alg to these 5, 10, or 15 wt.% PEGDA precursor solutions, we raised the viscosity from <1 mPa*s to 50 mPa*s, which enables VAM of low molecular weight PEGDA. The fabricated hydrogels have customizable mechanical properties, ranging from 14 ± 4 kPa to 90 ± 24 kPa, and 289 ± 121 kPa and correspond to equilibrium water contents of 96.8 ± 0.3%, 91.2% ± 0.8% and 84.1% ± 0.9%. The printed structures had minimum feature sizes ranging between 56 ± 9 μm for 5% PEGDA + 0.5 wt.% Alg, 47 ± 12 μm for 10% PEGDA + 0.5 wt.% Alg, and 39 ± 7 μm for 15% PEGDA + 0.5 wt.% Alg. Additionally, these materials are printable into designs with internal voids, unsupported struts, and interlocked features. Overall, this work establishes a low cost, mechanically tunable hydrogel platform for high resolution VAM which can improve accessibility and adoption.
Learning descriptors to predict organic structure-directing agent applicability in zeolite synthesis
Authors: Hoffman Alexander , Xie Mingrou , Gómez-Bombarelli Rafael
Published: October 2024

Zeolite synthesis frequently relies on organic structure-directing agents (OS- DAs), but the process of identifying the best OSDA to synthesize a given zeolite remains difficult. We use previously gathered binding energy data, in additional to the formation energies of the siliceous zeolite frameworks and approximate binding entropies of OSDAs to develop new descriptors to improve predictions based on known OSDA-zeolite pairs in the litera- ture. Our earlier work used templating energy (ET ) to rank the most likely OSDA-zeolite pairs to be produced from synthesis. Using literature recall area-under-the-curve (AUC) as a performance metric, we find that comput- ing energies associated with the net transformation that occurs during zeo- lite synthesis (the sum of the formation energy of the zeolite framework and the OSDA binding energy) provides a modest improvement over ET when predicting the zeolite phase that a given OSDA produces, from 67.1% aver- age literature recall to 69.1%, but slightly worsens predictions for the best OSDA for a given zeolite framework, from 67.7% to 64.9%. We then use machine learning symbolic regression to develop a new descriptor, which we call αT , that slightly improves upon ET for predicting an OSDA for a given framework, with an average literature recall of 68.2%. While zeolite synthesis remains difficult to predict a priori, the approaches used in this work provide one option for improving these predictions.
A lanthanide MOF with nanostructured node disorder
Authors: Griffin Sarah , Meekel Emily , Bulled Johnathan , Canossa Stefano , Wahrhaftig-Lewis Alexander , Schmidt Ella , Champness Neil
Published: October 2024

The synthesis and structural characterization of a new metal organic framework, UoB-100(Dy), is reported. Average structure refinements indicate that the node is disordered between two orientations of the nonanuculear secondary building unit (SBU). By performing 3D diffuse scattering (DS) analysis and Monte Carlo (MC) simulations, we confirm the presence of strong correlations between the metal clusters of UoB-100(Dy). These nodes assemble into a complex and novel nanodomain structure. Quantum mechanical calculations identify linker strain as the driving force behind the nanodomain structure. The implications of such a nanodomain structure for the magnetic, gas storage, and mechanical properties of lanthanide MOFs are discussed.
Microscopic Mechanism of Water-Assisted Diffusional Phase Transitions in Inorganic Metal Halide Perovskites
Authors: Liu Jialin , Hao Xiangming , van Huis Marijn , Fan Zhaochuan
Published: October 2024

The stability of perovskite materials is profoundly influenced by the presence of moisture in the surrounding environment. While it is well-established that water triggers and accelerates the black-yellow phase transition, leading to the degradation of the photovoltaic properties of perovskites, the underlying microscopic mechanism remains elusive. In this study, we employ classical molecular dynamics simulations to examine the role of water molecules in the yellow-black phase transition in a typical inorganic metal halide perovskite, CsPbI3. We have demonstrated, through interfacial energy calculations and classical nucleation theory, that the phase transition necessitates a crystal-amorphous-crystal two-step pathway, rather than the conventional crystal-crystal mechanism. Simulations for CsPbI3 nanowires show that water molecules in the air can enter the amorphous interface between the black and yellow regions. The phase transition rate markedly increases with the influx of interfacial water molecules, which enhance ion diffusivity by reducing the diffusion barrier, thereby expediting the yellow-black phase transition in CsPbI3. We propose a general mechanism through which solvent molecules can greatly facilitate phase transitions that otherwise have prohibitively high transition energies.
Assessment of free energies from electrostatic embedding density functional tight binding-based/molecular mechanics in periodic boundary conditions
Authors: Bonfrate Simone , Park Woojin , Trejo-Zamora Dulce , Ferré Nicolas , Choi Cheol Ho , Huix-Rotllant Miquel
Published: October 2024

Electrostatic embedding Quantum mechanics / molecular mechanics (QM/MM) methods in periodic boundary conditions can successfully describe the condensed phase reactivity of a fragment treated at the QM level with an atomistic description of an electrostatic environment treated at the MM level. The computational cost of ab initio QM methods limits the phase space sampling, affecting thus statistical quantities like free energies. Here, we explore the accuracy of the semi-empirical density-functional based tight-binding (DFTB) method by comparing the free energy profiles from several methods and parameters in the DFTB/MM to ab initio QM/MM free energy simulations. We show that DFTB2 correctly describes the free energy barrier of cis/trans isomerization of proline in water, the intramolecular proton transfer in pterin, and the nucleophilic fluoride substitution of chloromethane, showing a qualitatively good agreement with respect to experimental or ab initio simulations. DFTB3 describes well the free energy barriers but tends to favor weak endothermic reactions. None of the tested DFTB methods is able to predict a simultaneous water-assisted proton transfer for pterin, predicting rather a sequential proton transfer involving ionic water intermediates
Amesformer: a graph transformer neural network for mutagenicity prediction
Authors: Thompson Luke , Evans Josiah , Matthews Slade
Published: October 2024

The Ames mutagenicity test is a gold standard assay for the safety assessment of new chemicals. However, many in silico models rely on challenging-to-interpret ensemble strategies and molecular fingerprint data which neglects gestalt molecular structure. To improve upon these models, we propose AmesFormer, a graph transformer neural network which shows state-of-the-art performance when paired with our new Ames dataset. We briefly review the current state of Ames modelling with a focus on graph neural networks. We then benchmark AmesFormer on a standardised test dataset against 22 other Ames models, achieving state of the art (SOTA) performance. We then uniquely report the calibration performance of our model and attempts to improve it using temperature scaling. We support our findings with reference to other models from the literature and with developments in machine learning (ML) and graph theory. Overall, we present a high-performance, accessible, and open-source computational model for Ames mutagenicity, with significant potential for regulatory and drug development applications
PRÁTICAS INCLUSIVAS JUNTO A ESTUDANTES COM TRANSTORNO DO ESPECTRO AUTISTA (TEA) NO ENSINO SUPERIOR: REALIDADE, DESAFIOS E PRÁTICAS EXITOSAS
Authors: Nunes Lorena de Almeida Cavalcante Brandão , Marques Jaqueline Ferreira
Published: October 2024

Ao longo da história, tem se dado um processo de luta pelos direitos das pessoas com deficiência e uma de suas consequências foi o maior ingresso, recentemente observado, desse público no Ensino Superior. No presente artigo, pretendeu-se investigar, mediante revisão da literatura nacional, especificamente a inclusão escolar de estudantes com Transtorno do Espectro Autista (TEA) no âmbito do Ensino Superior, mapeando a realidade atual e identificando desafios e práticas exitosas. Comparando-se ao que ocorre na Educação Básica, os resultados indicaram que há escassez de estudos científicos sobre a inclusão de autistas no Ensino Superior. A leitura e análise das produções obtidas permitiu ainda identificar que, a despeito dos avanços ocorridos especialmente em termos de legislação, ainda há um longo caminho a ser percorrido a fim de que a inclusão seja efetiva, caminho esse que envolve a transformação de condições que consistem em entraves para a inclusão, bem como a disseminação de práticas exitosas.
Gombrowicz, Borges y la trampa de un Cosmos cartográfico
Authors: Ubelaker Andrade Max
Published: October 2024

En su novela Cosmos (1965), Witold Gombrowicz describe la creación compulsiva de una cartografía inasimilable: un ‘mapa’ idiosincrásico que crece espontáneamente de la mirada de su narrador, envolviéndolo en una estructura cambiante e inestable que sutilmente guía sus acciones. Este ensayo propone que Gombrowicz, después de más de 20 años en Buenos Aires, escribe Cosmos, en parte, como una respuesta compleja a Jorge Luis Borges y su rol como el escritor más celebrado de Argentina. Sugiere que Gombrowicz usa la novela para explorar sus ideas sobre las posibilidades generativas de la marginalidad cultural en Argentina y Polonia mientras responde a uno de los cuentos más conocidos de Borges: “La muerte y la brújula” (1942).
Más allá de los límites: Memorias, silencios y afectos en "Secretos de lucha" (2007)
Authors: Rivero Elizabeth G.
Published: October 2024

Secretos de lucha, documental producido por la compañía filmográfica francesa S.M.A.C, es la ópera prima de la directora Maiana Bidegain (1977), nacida en Bayona, Francia. Hija de exiliados de la dictadura cívico-militar uruguaya (1973-1985), en este film Bidegain intenta desvelar una historia familiar plagada de silencios que refleja una historia comunitaria no menos censurada y fragmentada. A partir de un marco teórico interdisciplinar que se nutre fundamentalmente de los Estudios de la Memoria, los Estudios Fílmicos y la Teoría de los Afectos, propongo en este ensayo que el documental de Bidegain transita y tensa diferentes límites discursivos, conceptuales y estéticos para examinar, desde su óptica de hija de afectados directamente por la dictadura uruguaya, las posibilidades y restricciones en la construcción de la memoria del pasado reciente. Para ello, el film explora modos alternativos de acceder a su conocimiento a través del potencial afectivo del film y de impulsar el compromiso ético y político de los espectadores con los eventos del pasado dictatorial y su legado.
Nasser Majed: A Hidden Narrative of Calligraphic Transformation in the Second Half of the 20th Century
Authors:   ,   Lebanese American University -- Chouran Beirut, Ghannoum Rima
Published: October 2024

Research on Arabic calligraphy during the 20th century has mainly focused on prominent calligraphers who have mastered the “art” of calligraphy. However, this focus overlooks the functions of calligraphy in the second half of the century that go beyond the artistic. Indeed, calligraphers played an indispensable role in the emerging new mass media. This thesis studies the evolving role of calligraphy during this transitional period through the works of Nasser Majed (1943-2015). Majed was a prolific calligrapher who worked in various mediums and fields, creating calligraphy for newspapers, magazines, advertisements, television broadcasts, paintings, book covers, atlases, fonts, and a Qur’an. As such, his work was at the heart of a capitalist and consumer-driven economy, in which calligraphers produced in commercial calligraphy daily. Majed’s experience and decades-long career provide unique insights into the evolution of calligraphic practices and the adaptation of calligraphy, employing new technologies to meet the demands of the second half of the 20th century. The research methodology includes a study of Majed’s formation, including his education, early career, and calligraphic tools. It also includes an overview of the status of Arabic calligraphy at the period of his artistic production, along with the social, political, and economic context during the second half of the 20th century. This research then examines Majed’s work and classifies it between “high-end” calligraphy (rooted in the traditional) and commercial calligraphy that was highly accessible, popular, and mass-produced. This helps us understand his contribution and how his calligraphy adapted to these media. Arguably, his commercial work was more impactful than his high-end work, which serves as a testament to the role of calligraphy during his time.
Hubungan Derajat Lesi Radiografi Toraks Pada Pasien TBC Paru Dewasa Disertai DM Tipe II Terkontrol Dengan Kadar Hemoglobin Di Rumah Sakit Royal Prima Kota Medan
Authors: Nazara Niscaya Aprian , Soekardi Adi , Lubis Yolanda Eliza Putri
Published: October 2024

Tuberkulosis (TBC) disebabkan oleh bakteri mycobacterium tuberculosis dan menyebabkan radang parenkim paru. Diabetes Melitus (DM) merupakan salah satu penyakit komorbid yang memengaruhi gambaran klinis tuberkulosis. Hemoglobin (Hb) merupakan protein yang memberi warna merah pada darah, yang berfungsi membawa oksigen dan terdiri atas besi. Tujuan penelitian ini adalah untuk melihat hubungan derajat lesi radiografi toraks pada pasien TBC paru dewasa disertai DM tipe II terkontrol dengan kadar hemoglobin di Rumah Sakit Prima Kota Medan. Jenis penelitian yang dilakukan adalah penelitian observasional analitik deskiptif pendekatan desain cross sectional dan bersifat retrospektif. Teknik pengambilan sampel adalah purposive sampling serta menggunakan data sekunder. Diperoleh sebanyak 70 data pasien yang memenuhi kriteria inklusi objek penelitian. Hasil penelitian menunjukkan jenis kelamin paling banyak ditemukan adalah laki-laki. Kadar hemoglobin pada laki-laki dan perempuan banyak ditemukan kurang dari normal. Berdasarkan kelompok umur mayoritas 56-65 tahun. Gambaran radiografi foto toraks paling sering ditemukan adalah konsolidasi dengan derajat lesi far advanced. Pada penelitian ini menunjukkan tidak adanya hubungan derajat pada pasien tuberkulosis paru dewasa disertai DM tipe II terkontrol dengan kadar hemoglobin. Dan tidak adanya hubungan radiografi toraks pada pasien tuberkulosis paru dewasa disertai DM tipe II terkontrol dengan kadar hemoglobin.
HEALING HORIZONS: AI AND ML INNOVATIONS IN PHARMACEUTICALS
Authors: Dr Farhat ul ain Sonia
Published: October 2024

Artificial Intelligence (AI) and Machine Learning (ML) are transforming the pharmaceutical industry, ushering in an era of efficiency, precision, and personalized treatment. This paper reviews the innovations brought by AI and ML across various stages of pharmaceutical development—from drug discovery and clinical trials to personalized medicine and supply chain optimization. AI-driven algorithms have significantly accelerated drug discovery by identifying potential drug candidates and predicting their efficacy, thus reducing time and costs. ML models are being employed in clinical trial optimization, helping to select suitable candidates, manage data, and predict trial outcomes with greater accuracy. Additionally, AI and ML are enhancing personalized medicine by tailoring treatment plans to individual patient profiles, thereby improving therapeutic effectiveness and minimizing side effects. This paper also explores the role of AI in optimizing pharmaceutical supply chains, streamlining production, and predicting demand, thereby reducing wastage and enhancing efficiency. Despite these advancements, challenges such as data privacy concerns, regulatory hurdles, and the need for large, high-quality datasets persist. This review highlights both the potential and limitations of AI and ML in reshaping the pharmaceutical landscape, emphasizing the need for collaboration between stakeholders—including researchers, regulatory bodies, and pharmaceutical companies—to address existing challenges. The study concludes that AI and ML are poised to play a pivotal role in transforming the pharmaceutical industry, ultimately leading to faster, safer, and more effective treatments. Future research should focus on improving AI transparency and developing robust ethical frameworks to facilitate widespread adoption in pharmaceuticals.
मोैर्यकालीन सामाजिक व्यवस्था का ऐतिहासिक अध्ययन
Authors: Singh Arvind Kumar , Parveen Shagufta
Published: October 2024

मनुष्य एक सामाजिक प्राणी है, वह अपना जीवन समाज के अन्तर्गत ही व्यतीत करता है और आजीवन समाज से जुड़ा रहता है। व्यक्ति का जन्म, पालन पोषण, शिक्षा, जीवन यापन सभी कुछ समाज में ही होता है। इस तरह मनुष्य और समाज का अन्योन्याश्रित सम्बन्ध है। मानव जीवन की प्रारम्भिक अवस्था में समाज का स्वरूप अनिश्चित एवं अविकसित था धीरे- धीरे लोग एक दूसरे के सम्पर्क में आते गये होंगे और सामाजिक सम्बन्ध निर्मित होते गये, जिसके फलस्वरूप समाज का निर्माण हुआ। यह भी कहा जा सकता है कि लोगों की एक साथ रहने की प्रवृत्ति एवं जीवन को व्यवस्थित रूप देने की इच्छा के परिणामस्वरूप समाज का निर्माण हुआ।1 मौर्य काल अनेक वर्णों और समूहों में बंटा हुआ था, इनके सामाजिक आचार विचार, रहन सहन और व्यवहार भी एक दूसरे से पृथक थें कालान्तर में इसी सामाजिक विभाजन के कारण अनेक सामाजिक संस्थाएं बनी जो मनुष्य के सामाजिक जीवन को उद्घाटित करने में प्रेरक तत्व बनी। धीरे-धीरे समाज के विविध पक्षों से सम्बन्धित सामाजिक व्यवस्थाओं का गठन हुआ। इन व्यवस्थाओं ने समाज को पूर्णता प्रदान की और विकास की ओर अग्रसर किया। समाज को पूर्णता प्रदान करने वाली इन्हीं व्यवस्थाओं में वर्ण व्यवस्था भी थी, इस व्यवस्था के अन्तर्गत प्रत्येक व्यक्ति को अपने स्वाभाविक गुणों के अनुरूप स्थान मिलता था। अपनी प्राकृतिक प्रवृत्ति और प्रतिभा के अनुरूप सम्पूर्ण मानव समाज चार वर्गों में विभक्त था।2 इस व्यवस्था के पूर्व गुप्तकालीन सामाजिक आयाम द्वारा भारतीय समाज का वर्णों में विभाजन किया गया। यह वर्ण विभाजन व्यक्ति के उसके स्वाभाविक गुणों का आधार था। समाज का यह वर्णगत विभाजन तत्कालीन सामाजिक जीवन का आधार थां जिससे प्रेरित होकर प्रत्येक व्यक्ति अपने लिए निर्धारित कर्तव्यों को करते हुए इस सामाजिक व्यवस्था का पालन करता था।
IMPACT OF CASHLESS PAYMENTS ON IMPULSE BUYING BEHAVIOUR OF GEN Z
Authors: Goyal Manisha
Published: October 2024

This study investigates the effect of cashless payments on Generation Z's impulse buying behavior in Mumbai. With the growing ubiquity of digital payment methods, companies and governments must understand their impact on customer behaviour, particularly among young adults. The goal was to look at how the use of cashless payments influences impulse buying among Generation Z customers. The study included 122 individuals aged 16 to 26 years old, chosen using a stratified random selection procedure to guarantee representation across key demographic criteria such as gender and socioeconomic status. Data was gathered using structured surveys that focused on participants' use of digital payment methods and their proclivity for impulsive purchases. According to the findings, the ease and accessibility of cashless transactions have a substantial impact on Generation Z's willingness to make impulsive purchases. This study adds to the current literature by shedding light on the behavioral dynamics of young consumers in metropolitan settings in terms of digital payments and impulsive purchasing. The consequences include that firms and marketers should modify their tactics to fit Generation Z customers' tastes and behaviors affected by the proliferation of cashless payment technology in cities such as Mumbai.
Production of esterase by Fusarium culmorum grown in the presence of different concentrations of di(2-ethylhexyl) phthalate and calcium ion in submerged fermentation
Authors:   Research Centre for Biological Sciences, Universidad Autónoma de Tlaxcala, Ixtacuixtla, Tlaxcala, 90120, Mexico., Chamorro-Mejía Alejandro , aramillo-Quintero Lidia Patricia , Sánchez Carmen ,   Bachelor in Industrial Chemistry, Universidad Autónoma de Tlaxcala, Apizaco, Tlaxcala, 90401, Mexico,   Faculty of Basic Sciences Engineering and Technology, Universidad Autónoma de Tlaxcala, Apizaco, Tlaxcala, 90401, Mexico
Published: October 2024

Phthalates are plastic additives used as plasticizers in the manufacture of flexible plastic materials. These compounds, such as di(2-ethylhexyl) phthalate (DEHP) are toxic substances to the environment and human health, and have been detected as environmental pollutants. In this study, the activity of esterase produced by Fusarium culmorum grown in media supplemented with different concentrations of DEHP (1.5, 3 and 4 g/L) and calcium ion (0.1 and 0.5 g/L) in submerged fermentation was characterized by biochemical tests and polyacrylamide gel electrophoresis. The greatest esterase activity was observed in cultures grown in media added with 3 g of DEHP/L and 0.5 g of calcium ion/L, followed by those cultures grown in media containing 1.5 g of DEHP/L. Whereas cultures grown on 4 g of DEHP/L had the lowest esterase activity. In general, cultures added with 0.5 g of calcium ion/L had the maximum enzymatic activity and the highest enzymatic productivity in the media tested. High concentration of DEHP were used as the sole source of carbon and energy by F. culmorum. It is suggested that the calcium ion favored the esterase production during the DEHP biodegradation. However, further studies are needed to understand the relationship between calcium ion, fungal growth, and enzyme production to provide the appropriate concentration of this ion in the culture medium.
ETIKA PROFESI, AUDIT TENURE, DAN TEKNOLOGI INFORMASI BERPERAN PENTING DALAM KUALITAS AUDIT ERA 5.0
Authors: Maharani Ade Retno , Novita Novita
Published: October 2024

Tujuan penelitian ini untuk menganalisis peran penting etika profesi, audit tenure dan kemampuan menggunakan teknologi informasi terhadap kualitas audit di era 5.0. Variabel yang digunakan meliputi etika profesi, audit tenure, dan kemampuan menggunakan teknologi informasi sebagai variabel bebas dan kualitas audit sebagai variabel terikat. Penelitian ini menggunakan data primer yang diperoleh dari hasil kuesioner yang disampaikan dengan cara menyebarkan link kuesioner kepada auditor. Sampelnya adalah 111 auditor yang beroperasi pada Kantor Akuntan Publik (KAP) di DKI Jakarta. Mekanisme pengolahan dan kajian data menggunakan Partial Least Square (PLS). Hasil penelitian ini menunjukkan bahwa etika profesi, audit tenure dan kemampuan menggunakan informasi berpengaruh positif dan signifikan terhadap kualitas audit. Hal ini menunjukkan auditor memiliki etika profesi, menerapkan audit tenure dan kemampuan menggunakan teknologi informasi dalam melaksanakan praktik audit memproduksi laporan audit yang bermutu. Studi menunjukkan bahwa meningkatkan etika profesi, audit tenure, dan kemampuan menggunakan teknologi informasi dapat memperkuat integritas dan akurasi audit, menghasilkan keputusan yang lebih andal bagi pemangku kepentingan.
TERAPIA ASSISTIDA POR ROBÔ E O TEABOT: UMA EXPERIÊNCIA NA APAE DE SERRA TALHADA
Authors: Santos José Antônio Pedro dos , Lopes Júlio César da Costa , Pereira Ellen Polliana Ramos Souza
Published: October 2024

Pessoas que possuem a alexitimia enfrentam desafios em expressar e interpretar expressões faciais ou tons de voz, o que afeta a sua compreensão emocional e a capacidade de
compreender as emoções dos outros. Pesquisas indicam que a prevalência desse distúrbio é
significativamente maior em indivíduos com Transtorno do Espectro Autista, atingindo quase
50% dessa população. Este trabalho apresenta o TEABot, um robô com inteligência artificial
desenvolvido para auxiliar no treinamento das expressões faciais emocionais na terapia assistida por robô, conduzida pela equipe multidisciplinar da APAE de Serra Talhada. Nove crianças,
com idades entre 2 e 9 anos, participaram ativamente, totalizando 42 sessões de terapia, com
um tempo de interação de 950 minutos e o registro de 14 mil imagens pelo robô. As crianças
demonstraram um alto nível de interesse durante as interações e o TEABot desempenhou um
papel importante no processo de aprendizado emocional delas. Contudo, com a pandemia de
COVID-19, muitos atendidos não puderam frequentar a associação por pertencerem a grupos
de risco. Para contornar essa situação, o TEABot foi transformado em um aplicativo gamificado, para que os pacientes possam realizar tratame
SATISFAÇÃO NO TRABALHO DE CUIDADORES DE PESSOAS COM DEFICIÊNCIA
Authors: Pinheiro Kelly Vale , Silva Simone Souza da Costa , Ramos Camila Carvalho , Pontes Fernando Augusto Ramos , Medeiros Marcelo
Published: October 2024

A qualidade de cuidados prestados às pessoas em situação de vulnerabilidade, em especial com deficiência e em serviços de acolhimento, associada à crescente redução mundial de
engajamento profissional no cuidado em saúde, reflete na percepção que cuidadores têm sobre
sua satisfação no trabalho. Esta pesquisa propôs descrever a percepção de satisfação no trabalho de cuidadores de pessoas com deficiência em instituição de acolhimento brasileira baseada
no enfoque da teoria de Herzberg e nos fundamentos da psicologia positiva. Partindo-se de um
inventário social e demográfico e 11 entrevistas coletivas, foram coletadas informações sobre
fatores promotores de satisfação de um grupo de cuidadores de pessoas com deficiência em acolhimento institucional. Com a análise de conteúdo e o método de Reinert associados, emergiram
dos dados analisados duas categorias: satisfação consigo e satisfação com o outro. A satisfação
envolvendo aspectos individuais (aprendizado pessoal, doação, prazer pessoal e reconhecimento) e sociais (prazer relacional, aprendizado do outro, prazer do outro, adoção e expectativa de
vida) tem como base as interações com o acolhido. Não ter um desenho longitudinal foi um
fator limitador deste estudo, sendo também uma proposta para futuras pesquisas, considerando
que as relações, constituintes propulsoras do desenvolvimento humano, processam-se ao longo
do tempo.