bluuebunny/crossref_metadata_2025 huggingface dataset:
BİST 100 getiri zaman serisinin kaotik analizi ve ANFIS ile kısa dönemli öngörülebilirliği
Authors: MOLLA Büşra , CAGIL Gültekin , UYAROĞLU Yılmaz
Published: March 2021

Borsa İstanbul’da işlem gören, halka açıklık oranı, işlem hacmi ve piyasa değeri gibi kriterler yönünden en yüksek 100 pay senedinin başarısının değerlendirilmesinde BİST 100 endeksi kullanılmaktadır. Bu çalışmada, BİST 100 getirilerinin kaotik yapıya sahip olup olmadığının ve kısa dönemli öngörülebilirliğinin tespit edilmesi amaçlanmıştır. Öncelikle, 02.01.2008 ile 02.01.2018 tarihleri arasındaki günlük BİST 100 fiyat endeksi verileri kullanılarak BİST 100 getirileri elde edilmiştir. En uygun gecikme zamanı ve gömülü boyut kullanılarak, kaos analizi için gerekli olan faz uzayı yeniden oluşturulmuştur. Ardından, bu getiri serisi için elde edilen yeni faz uzayında kaotik çekerin korelasyon boyutu hesaplanmıştır. Çalışılan BİST 100 yapısının doğrusal olup olmadığını tespit edilmesinde BDS (Brock, Dechert ve Scheinkman) testinden yararlanılmıştır. Bununla beraber, serinin uzun dönemli hafızaya sahip olup olmadığı, dönüştürülmüş genişlik yöntemi ile Hurst üsteli katsayısı belirlenmiştir. Getiri serisinin pozitif Lyapunov üsteline bakılarak, bu serinin kaotik davranış gösterip göstermediği tespit edilmiştir. Kaos analizinin ardından, BİST 100 endeksi YSA ve ANFIS modeli ile tahmin edilmiştir. En düşük hata değerine sahip modelin çıktıları getiri serisine dönüştürülerek BİST 100 getirilerinin tahmini değerleri elde edilmiştir.
Sonlu elemanlar yöntemi ile çatlaklı konik kirişlerde serbest titreşim analizi ve hasar konumlarının belirlenmesi
Authors: KAHYA Volkan , KARACA Sebahat , GÜNEŞ Sevgi
Published: March 2021

Bu çalışmada, hasarlı konik kirişlerin serbest titreşim analizleri için iki düğüm noktalı ve her bir düğüm noktasında dörder serbestliği (yatay ve düşey ötelenme, dönme ve eğrilik) bulunan bir sonlu eleman modeli sunulmuştur. Değişken kesitli Bernoulli-Euler kirişi için rijitlik ve kütle matrisleri Galerkin yöntemi ile elde edilmiştir. Sonlu eleman formülasyonunda, uzama titreşimleri için doğrusal Lagrange, eğilme titreşimleri için ise beşinci dereceden Hermit polinomları seçilmiştir. Hasarın tanımlanması için eleman rijitlik matrisi bir rijitlik kaybı katsayısı ile çarpılmıştır. Hasar sebebiyle eleman kütle matrisinde değişim olmadığı kabul edilmiştir. Önerilen elemanın doğruluğu, literatürdeki çalışmalarla karşılaştırmalar yapılarak gösterilmiştir. Modal eğrilik değişiminin hasar (çatlak) konumlarının bulunmasındaki başarısını göstermek amacıyla bazı sayısal sonuçlar sunulmuştur.
Ortadan mesnetli mikro kirişin doğrusal titreşim hareketleri
Authors: AKKOCA Şevki , BAĞDATLI Süleyman Murat , TOĞUN Necla
Published: March 2021

İmalat teknolojisindeki gelişmeler neticesinde ortaya çıkan mikro ve nano elektromekanik sistemler (MEMS ve NEMS); biyosensörler, aktüatörler ve atomik kuvvet mikroskopları (AKM) gibi mikro ve nano yapıya sahip sistemlerde çok yaygın olarak kullanılmaktadır. NEMS ve MEMS’ de kiriş veya benzeri elemanlar ve yapılar bulunmaktadır. Bu elemanlar sabit kesitli olduğu gibi değişken kesitlere de sahip olabilmektedirler. Söz konusu sistemler içindeki kiriş elemanların statik ve dinamik davranış karakterlerinin bilinmesi çok önemlidir. Çünkü sistemin sorunsuz çalışması için ihtiyaç duyulan çalışma frekansının, tasarlanan sistemin doğal frekansı ile aynı olmaması gerekmektedir. Bu nedenden dolayı mikro ve nano elemanların serbest titreşim analizlerinin yapılması sorunsuz bir tasarım için hayati önem taşımaktadır. Bu kapsamda, ortadan mesnetli mikro kirişin titreşim analizleri yapılmıştır. Mikro kiriş seramik özellikte olup elektrik alan içerisine yerleştirilmiş ve mesnetlerin pozisyonları değiştirilerek titreşim karakterleri incelenmiştir. Hareket denklemleri modifiye gerilme çifti teorisi kullanılarak Hamilton metoduna göre elde edilmiştir. Hareket denklemi, pertürbasyon metotlarından biri olan çok zaman ölçekli metot ile çözümü elde edilmiştir. Doğal frekanslar ve mod şekilleri, boyutsuz parametreler mesnet konumu, gerilme katsayısı ve mikrokirişlik katsayısına bağlı olarak elde edilmiştir.
Polietilen ince filmin dielektrik özelliklerinin frekans, sıcaklığa bağlı davranışı ve camsı geçiş sıcaklığının tespiti
Authors: YAKUT Şahin
Published: March 2021

35000 g/mol moleküler ağırlığa sahip külçe halindeki polietilenden (PE), termal buharlaştırma yöntemiyle 10-3 Torr vakum altında 750 nm kalınlığında PE ince filmler elde edildi. PE ince filmler alüminyum (Al) elektrotlar arasında kapasitör formunda hazırlandı. Hazırlanan PE ince filmlerin 10-106 rad/s açısal frekans ve 233 – 373 K sıcaklık aralığında dielektrik ölçümleri yapıldı. Elde edilen sonuçlar Cole-Cole modeli ile analiz edildiğinde PE ince filmlerin dielektrik sabitinin oda sıcaklığında yaklaşık 20 olduğu, yapıda üç farklı polarlanma mekanizmasının farklı frekans ve sıcaklık aralıklarında etkili olduğu görüldü. Bu mekanizmalardan α-rölaksasyonunun polimerlerde gözlenen camsı geçiş davranışını temsil ettiği belirlendi. Vogel-Fulcher-Tamman (VFT) modeli kullanılarak yapılan analizde PE ince filmin camsı geçiş sıcaklığının 315 K (42ᵒC) civarında olduğu tespit edildi. PE ince filmin, termal buharlaştırma yöntemiyle üretilmesinde ana zincirinde kırılmalar meydana gelebileceği ve lineer bir zincir formundan çapraz bağlı ağ formuna geçilebileceği görülmüştür. Elde edilen sonuçlar PE’nin ince film formunda külçe formuna kıyasla daha yüksek dielektrik sabit değerlerine ulaşabildiğini göstermiştir. Buna göre, PE ince filmin mikro ve nano boyutta enerji depolama sistemlerinde kullanımı da mümkün olabilir.
Profile of Student Career Commitments Based On Batak Subculture
Authors: Lesmana Gusman
Published: March 2021

The article aims to describe the results of the analysis of career commitment based on five Batak subcultures namely; Karo Batak, Mandailing Batak, Toba Batak, Pakpak Batak, and Simalungun Batak at the Faculty of Education, Muhammadiyah University of North Sumatra enrolled in the 2019/2020 school year. Description of this career commitment using the instrument used is a measurement tool and predictions of Gary J. Blau's career commitment. This article is expected to contribute to the development of knowledge in multicultural fields, especially cross-cultural fields in guidance and counseling services. The results of this study can be used for the purposes of developing the science of guidance and counseling in the study of multicultural competencies both conceptually and practically.
Encapsulation method developed for OLED devices mounted at laboratory
Authors: Santos Emerson Roberto , Yuki Erik Yassuo , Hui Wang Shu
Published: March 2021

A simple method with low cost of encapsulation for organic light emitting diode (OLED) devices mounted at laboratory was proposed to obtain considerable increase of the lifetime. In this study, it was used a capsule formed by: glass slide as substrate, a layer of polyvinyl acetate glue diluted in methyl alcohol, a layer of calcium oxide as secant and epoxy placed at the edges of capsule. The performance of this capsule was analyzed using a thin film of polymer semiconductor called as PEDOT:PSS, that is sensitive to moisture and oxygen from atmospheric air. The PEDOT:PSS thin layer was deposited between anode and cathode electrodes using commercial indium tin oxide (ITO) thin film deposited on glass substrate. The capsule was placed covering completely the PEDOT:PSS thin film, and the electrical resistance was measured by elapsed days. This result revealed lowest electrical resistance compared with other methods, showing also good performance as encapsulation process.
Reasonable Entrepreneurial Risk: Behavioural Criteria for Corporate Managers
Authors: Sosnovskikh Sergey , Cherkasova Oxana
Published: March 2021

This paper discusses the essence of the entrepreneurial risk, ethical and legal standards, which must be adhered to by the head of a commercial organisation. In the Russian legislation, there is debate concerning the boundaries of the responsibilities of the corporate manager. Existing literature doesn't contain many studies about the norms on the responsibility of persons authorised to act on behalf of a legal entity because it is new for Russian civil legislation, which shows the novelty of this study. We identify problematic aspects that arise both in the doctrine and judicial practice regarding the determination of the criteria of good faith and reasonable behaviour of the head of the corporation. Our study examines the legal nature of entrepreneurial risk and how it affects the formation of managerial decisions. As a result, we propose a basic model of the criteria for the good behaviour of a corporate manager within a reasonable entrepreneurial risk.
DEMOGRAPHIC SECURITY OF THE LVIV REGION: PROBLEMS AND RISKS OF ITS ACHIEVEMENT
Authors: PETROVSKA Myroslava , VERCHYN Nataliia , IVANOV Yevhen
Published: March 2021

The demographic situation in Lviv region has been assessed, namely – the population number and density, birth and death rates, the natural increase, the causes of death, the average life expectancy, age and sexual structure, demographic load, the age of maternity, and migration movement of population, as for the administrative-territorial units. The main problems and risks concerning demographic safety of the administrative subdivisions of Lviv region have been pointed out. The factors influencing this were determined, namely: the demogeographic location, economic, social, cultural, religion and behavioral factors, as well as indirect relationships with foreign policy, state and military safety through the social-geographic location. The new model of the demographic behavior that is being formed in Lviv region is characterized by the prevalence of families with few children, the low level of early marriages and births, as well as the increase in the average age of giving birth, the high level of extramarital births, and the prevalence of the psychological motives of giving birth. The migration behavior took the new features of the movement of urban dwellers and residents of remote villages into suburban areas, that caused the deterioration of the demographic indices and the decrease of demographic safety level. The method of the determining the integral assessments of the levels of demographic safety, demographic threats, demographic risk, and demographic danger of the region has been revealed. The level of the demographic safety (danger) is expressed by the indicators, which normalization serves as the basis for the calculation of the integral index of the demographic safety of the region. The latter was calculated from the official data of the State statistical service of Ukraine and the Main statistical office in Lviv region. The regional features of the demographic safety of Lviv region have been determined, and administrative-territorial units were typified according to the levels and tendencies of their demographic safety. It was determined that in 2018 five districts (Brody, Zhydachiv, Peremyshliany, Radehiv, and Stryi) and four cities of regional significance (Boryslav, Drohobych, Morshyn, and Chervonohrad) were in the state of demographic danger (0,0–0,382), while Yavoriv district and the city of Stryi – were in the state of demographic risk (0.619–0.854). No single administrative-territorial unit of Lviv region were in the state of demographic safety (0.855–1), while all the other units were in the state of demographic threat (0.383–0.618). The optimizing measures were proposed for minimizing the demographic danger and lessening demographic threats in Lviv region.
Psychological and Pedagogical Rehabilitation of Children Subjected to Violence and Abuse as Part of the Implementation of the Set of Measures “The World Begins with the Family” in the Volgograd Region
Authors: Kuchegasheva P.P. , Kubantseva A.P. , Oreshkina N.V.
Published: March 2021

The article describes the practice of psychological and pedagogical rehabilitation of children who have been subjected to ill-treatment and criminal attacks in the Volgograd region as part of the on-going set of measures aimed at the development of the system for ensuring safe childhood “The World Begins with the Family”. Special attention is paid to the traumatic consequences of violence and abuse, the manifestation of post-traumatic stress disorder, as well as the need for timely psy-chological and pedagogical rehabilitation and assistance to children who have been subjected to violence and abuse. The potential of using psychotherapeutic tools used in pivotal schools when working with children is analyzed. These schools are offices of emergency psychological assis-tance in their scientific and methodological district of the Volgograd educational cluster. The cluster allows environmentally friendly, fast and effective provision of one-time therapeutic assistance to the injured child, as well as build a system of long-term psychotherapeutic relationships.
Work Time Tracking Cyclogram as a Tool for Planning and Organizing Professional Activity for the Psychologist in the Educational Sector (Teacher-Psychologist)
Authors: Oltarzhevskaya L.E. , Egupova O.V. , Kuznetsova A.A. , Zheludova A.M. , Malakhova N.E.
Published: March 2021

The article is devoted to the development and implementation of a unified electronic form of the edu-cational psychologists’ time tracking weekly cyclogram in educational organizations. This work represents the experience of inter-district cooperation of seventeen educational organizations (schools) in Moscow. Each school is a large educational complex, which includes fifteen to twenty educational buildings with 1.5 to 3.5 thousand students of all education levels overall and consists of 5 to 20 specialists of the psychological and pedagogical support service. The relevance of the chosen topic comes from the need to ensure a unified approach to the provision of psychological and pedagogical assistance through the development and introduction of a unified documentation regulation and standardized calculation of specialists’ workload. The introduction of a cyclogram single form allows pedagogical psychologists to conduct self-audits of their activities in accordance with the approved professional standard “Teacher-psychologist (psychologist in the field of education)”, and administrations for monitoring the activities of Service specialists and the distribution of workload between them. The article discloses the technological component of constructing a weekly cyclogram of teachers-psychologists’ professional activity taking into account all forms of work.
The Use of Ebru Drawing in the Psychological Correction of Anxiety in Adolescents with Traumatic Experience
Authors: Kuchegasheva P.P. , Koloteva E.Y.
Published: March 2021

The article presents the analysis of psychological and pedagogical correctional work with children and adolescents in difficult life situations and having traumatic experience. The work is carried out by pedagogical psychologists of the pivotal schools of the Volgograd educational cluster using the ebru-drawing technology.
Dupilumab: A Review of Present Indications and Off-Label Uses
Authors: Muñoz-Bellido FJ , Moreno E , Dávila I
Published: March 2021

Recent advances in our understanding of T2 inflammation have revealed more diseases in which T2 inflammation is involved. Dupilumab is a recently developed monoclonal antibody that blocks signaling of IL-4 and IL-13, both of which are crucial cytokines in the T2 response. New possible indications are increasingly explored and include skin diseases, such as prurigo nodularis, nummular eczema, allergic contact dermatitis, chronic hand eczema, spontaneous chronic urticaria, bullous pemphigoid, alopecia areata, and Netherton syndrome, as well as respiratory diseases, such as allergic bronchopulmonary aspergillosis, chronic eosinophilic pneumonia, and allergic rhinitis. In addition, eosinophilic gastrointestinal disorders, particularly eosinophilic esophagitis, and food allergy, are also research fields of interest. Here, we review published data and clinical trials examining the use of dupilumab in these disorders.
IDENTIDADES EM TRANSIÇÃO: ENVELHECIMENTO E TECNOLOGIA CERÂMICA NO SAMBAQUI MORRO DOS ANJOS, NO VALE DO RIBEIRA
Authors: De Alencar Soraya Martins
Published: March 2021

O vale do rio Ribeira de Iguape é considerado como uma área de confluência de territórios por suas características geomorfológicas, que permite o acesso entre o planalto e o litoral. E foi ocupado, ao longo de milênios, por grupos de pescadores, caçadores coletores complexos que erigiam montículos artificiais denominados sambaquis. O sambaqui Morro dos Anjos é o único desta região com remanescentes de afinidades biológicas com grupos ceramistas da tradição Taquara-Itararé e corresponde ao último período de ocupação dos sambaquieiros. As práticas funerárias poderiam enunciar algumas questões sobre como se estabeleciam as relações sociais entre esses grupos, segundo categorias de identidade, no processo formativo desse monumento. As evidências materiais da coexistência de longo prazo entre indivíduos de locais e práticas sociais distintas motivou diferentes estratégias de interação entre as categorias de idade e gênero, na conformação de uma identidade que defina e compreenda esse monumento nos seus próprios termos.
ASPECTOS MATERIAIS DOS SÍTIOS PEDREIRA E ÁGUA VERMELHA, BAHIA
Authors: Fernandes Henry Luydy Abraham
Published: March 2021

O presente artigo aborda dois sítios no sul da Bahia: Pedreira, escavado dentro de um projeto de contrato e Água Vermelha, alvo de um salvamento pontual de urnas funerárias. A partir de uma breve revisão de dados das fases Itanhém/Itaúnas da tradição Aratu, o contexto de ambos os sítios é usado para discutir as características da cultura material. Como resultado, considera-se que os conjuntos cerâmicos em tela podem ser entendidos como uma mescla entre elementos da tradição Aratu e Tupi, encontro que teria gerado a fase Itanhém / Itaúnas.
O ALTO PURUS E O SERINGUEIRO, SUA MEMÓRIA, SUA HISTÓRIA
Authors: Sugizaki Eduardo , De Araújo Adelmar Santos
Published: March 2021

O presente trabalho é uma análise inicial da relação entre história e memória no Alto Purus. No anseio de uma compreensão preliminar do seu processo histórico faz-se necessário sistematizar o estudo em três momentos respectivamente relacionados: da lenda à história, do período de exploração do Alto Purus e o das memórias do seringueiro. Nesse percurso, percebem-se os liames de uma memória oral com uma memória escrita sinalizando o alimento da história de um rio.
Reactor Design Pattern
Authors: Mijač Marko , García-Cabot Antonio , Strahonja Vjeran
Published: March 2021

In object-oriented (OO) applications, objects collaborate through message passing, which results in these objects being coupled and mutually dependent. These dependencies can be reactive, i.e. such that, for example, the state change of one object, requires automatic reaction in all dependent objects. Examples of such reactive dependencies can be found in various software systems, including rich graphical interfaces, spreadsheet systems, animation, robotics, etc. Unlike the reactive paradigm which natively provides abstractions and mechanisms for the management of reactive dependencies, the OO paradigm lacks proper support. Object-oriented applications developers often resort to the use of ad-hoc solutions or design patterns such as the well-known Observer pattern, which are not suitable for managing more complex scenarios. In this paper we offer a novel design pattern (REACTOR), which utilizes a graph data structure to improve the management of reactive dependencies in OO applications.
Mobile Applications to Fight against COVID-19 Pandemic: The Case of Saudi Arabia
Authors: Hidayat-ur-Rehman Imdadullah , Ahmad Arshad , Ahmed Manzoor , Alam Aftab
Published: March 2021

In order to fight against the COVID-19 pandemic the government of Saudi Arabia launched three mobile applications namely Tetamman, Tabaud & Tawakkalna to keep the public aware about the corona virus and ensure monitoring of the suspected cases. The objective of this study is to curb the spread of COVID-19 by enhancing social measures and investigate the role of mobile applications in achievement of this objective. Comprehensive review of the role of mobile applications was made and a survey approach was used to evaluate the effectiveness of these applications. Findings of the study indicate that the users perceive that the applications are successful in achievement of the objectives for which these applications were launched. The key performance indicators (KPIs) included in the survey were efficiency, ease of use, satisfaction of users, fulfilment of purpose, usefulness and helpfulness etc. The average number of respondents, who agreed that these applications are performing according to the mentioned KPIs, is 86.6% for Tetamman, 80.5% for Tabaud and 90% for Tawakkalna. More awareness campaigns are needed so that more people adopt the use of these applications, which could significantly help in identification of new casesand enhance telehealth and teleconsultations. Moreover, the applications should be upgraded for self-triage.
Medical Informatics in Indonesia: Importance, Development, and Future Directions
Authors: Hansun Seng
Published: March 2021

Medical Informatics (MI) is an emerging multidisciplinary study in academic fields. Also known as ‘Health Informatics,’ this study combines three different well-known fields; Information Systems (IS), Computer Science (CS), and Health Science (HS). MI is crucial because it could help in bridging the gap that is commonly found in conventional Healthcare services with the usage of Information Technology (IT). However, despite its vital role, the development of MI in Indonesia is still not satisfactory. Therefore, in this paper, the importance of MI as an academic discipline will be briefly discussed, followed by the description of MI development in Indonesia, and some suggestions for its future development.
Bilişsel Faktörler ile Depresif Semptomlar ve İyi Oluş Arasındaki İlişkide Psikolojik Dayanıklılığın Aracı Rolü
Authors: SAĞ Bilgen , BİLİCAN F. Işıl
Published: March 2021

Bu çalışma bilişsel faktörler (uyumsuz şemalar ve pozitif algı) ile psikolojik semptomlar (depresif semptomlar ve mental iyi oluş) arasındaki ilişkide psikolojik dayanıklılığın aracı rolünü incelemektedir. Onsekiz ile 30 yaş arasındaki 231 katılımcıya (174 kadın, 57 erkek) Young Şema Ölçeği, Pozitif Algı Ölçeği, Yetişkinler İçin Psikolojik Dayanıklılık Ölçeği, Beck Depresyon Ölçeği, Warwick Edinburg Mental İyi Oluş Ölçeği ve demografik bilgi formu uygulanmıştır. Katılımcıların yaşı 18 ile 30 arasında değişmektedir. Bulgular, şema alanlarından kopukluk/reddedilmişlik ve zedelenmiş otonomi/özerklik’in depresif semptomları; kopukluk/reddedilmişlik, zedelenmiş otonomi/özerklik, diğerleri yönelimlilik ve yüksek standartlar/bastırılmışlığın iyi oluşu; kopukluk/reddedilmişlik, zedelenmiş otonomi/özerklik, zedelenmiş sınırlar ve yüksek standartlar/bastırılmışlığın ise psikolojik dayanıklılığı yordadığına işaret etmiştir. Psikolojik dayanıklılık, yüksek standartlar/bastırılmışlık ve depresyon arasında tam; zedelenmiş otonomi/özerklik ve depresif semptomlar arasında kısmi aracı rolü oynamaktadır. Kopukluk/reddedilmişlik ve zedelenmiş otonomi/özerklik ile iyi oluş ile ilişkisinde psikolojik dayanıklılığın tam aracı rolü bulunmaktadır. Koruyucu bir faktör olan pozitif algı puanları yükseldikçe dayanıklılık ve iyi oluş düzeyi yükselmekte ve depresyon düzeyi azalmaktadır.
Toplum Ruh Sağlığı Merkezine Kayıtlı Şizofreni Hastalarına Bakım Verenlerin Hastalığa Yönelik İnançları ve Bakım Yükleri
Authors: BİLGEN Çiğdem , ERDAL Aysun , BİLGİLİ Naile
Published: March 2021

Bu çalışmanın amacı Toplum ruh sağlığı merkezine kayıtlı olan şizofreni tanılı hastalara bakım verenlerin ruhsal hastalığa yönelik inançlarının ve bakım yüklerinin belirlenmesidir. Araştırmanın örneklemini Keçiören ve Etimesgut Toplum Ruh Sağlığı Merkezleri’ne kayıtlı 218 şizofreni hastasının bakım verenleri oluşturmuştur. Veriler Nisan-Eylül 2018 tarihleri arasında sosyodemografik bilgi formu, Ruhsal Hastalığa Yönelik İnançlar Ölçeği ve Algılanan Aile Yükü Ölçeği kullanılarak toplanmıştır. Bakım verenlerin %63.3’ü kadın, yaş ortalamaları 50.31±11.74’tür. Ortalama 27.04±11.04 yıldır bakım verdikleri şizofreni hastası ile birlikte yaşamaktadırlar. Ruhsal Hastalığa Yönelik İnançlar Ölçeği’nden alınan puan arttıkça Algılanan Aile Yükü Ölçeği’nden alınan puan da artmaktadır. Toplum ruh sağlığı merkezine düzenli olarak giden şizofreni hastasına bakım veren bireylerin, her iki ölçekten aldıkları puanlar gitmeyen hastalara bakım verenlere göre anlamlı düzeyde düşük bulunmuştur. Şizofreni hastalarının toplum ruh sağlığı merkezine gitme sıklığı arttıkça bakım verenlerin merkezin hizmetlerinden memnuniyet düzeyi artmaktadır. Sonuç olarak bakım verenin hastalığa yönelik inançları algıladığı bakım yükünü etkilemektedir. Toplum ruh sağlığı merkezlerinde verilen hizmete şizofreni hastalarının düzenli katılımı, bakım verenlerin hastalığa yönelik inançlarının olumlu yönde değişimine ve algıladıkları bakım yükünün azalmasına katkı sağlamaktadır.
Sosyal Medya Kullanımı, Sağlık Algısı ve Sağlık Arama Davranışının Koronavirüs Korkusu Üzerine Etkisi
Authors: ÖZDEMİR Derya , ARPACIOĞLU Selim
Published: March 2021

Bu çalışmanın amacı koronavirüs salgını sonrası sosyal medya kullanımının, sağlık algısının ve sağlık arama davranışının incelenmesi ve de bunların koronavirüs korkusu üzerindeki etkisinin araştırılmasıdır. Bu amaç doğrultusunda 18 yaş üzeri 1020 yetişkin birey ile anket çalışması yapılmıştır. Katılımcılara Tanıtıcı Bilgi Formunun yanı sıra Sağlık Arama Davranışı Ölçeği, Sağlık Algısı Ölçeği ve Koronavirüs Korku Ölçeği verilmiştir. Yapılan araştırma sonucunda sağlık arama davranışlarına daha fazla önem veren kişilerde daha yüksek korona virüs korkusu saptanmıştır. Sağlık algısı yüksek olan kişilerde ise korona virüs korkusunun daha az olduğu bulunmuştur. Sosyal medyada geçirilen zamanın korona virüs korkusu üzerine etkisine bakıldığında ise sosyal medyada daha fazla zaman geçiren katılımcıların korona virüs korkularının arttığı görülmüştür. Sonuç olarak, çalışmamızda Türkiye’de COVID-19 salgını sonrası bazı kesimlerin koronavirüs korkusu ve sağlık arama davranışları açısından daha dezavantajlı olduğu görülmektedir. Bu dezavantajlı popülasyonlara yönelik koruyucu psikolojik destek hizmetlerinin sunulması ve özellikle sosyal medyadaki bilgi kirliliğini engelleyecek ve doğru bilgiye ulaşılmasını sağlayacak mekanizmaların hayata geçirilmesi önerilir. Ayrıca sağlık algısını artıracak ve sağlık arama davranışlarında olumlu değişikliklere neden olacak toplumsal müdahaleler halk sağlığı açısından koruyucu olacaktır.
Komposisi Fisikokimia Tepung Ubi Kayu dan Mocaf dari Tiga Genotipe Ubi Kayu Hasil Pemuliaan
Authors: Wa ode Nafilawati , Darmawati Emmy , Suro Mardjan Sutrisno , Khumaida Nurul
Published: March 2021

Faktor penting yang mempengaruhi karakteristik fisikokimia tepung adalah bahan baku tepung, genotipe/varietas serta proses pengolahan dalam pembuatan tepung. Penelitian ini bertujuan untuk mengevaluasi komposisi fisikokimia tepung ubi kayu dan mocaf dari tiga genotipe ubi kayu yaitu GX, G053 dan G390 yang merupakan hasil pemuliaan tim Croop Improvement IPB. Evaluasi komposisi fisikokimia dilakukan dengan menganalisis kadar air, karbohidrat, protein, lemak, abu, kadar HCN, rendemen dan derajat putih.  Berdasarkan hasil analisis diketahui bahwa setiap genotipe ubi kayu memiliki komposisi fisikokimia yang berbeda-beda dipengaruhi oleh jenis genotipe dan proses pengolahannya. Komposisi fisikokimia tepung ubi kayu dari genotipe G053 memiliki keunggulan rendemen (26.10%±0.01), karbohidrat (89.11%±0.015), protein (2.63%±0.014), derajat putih tertinggi (96.89%±0.02) serta kadar air terendah (6.73%±0.004). Tepung dari genotipe G390 memiliki keunggulan kadar abu (0.74%±0.015) dan lemak (0.59%±0.005) terendah. Tepung GX memiliki keunggulan HCN terendah (0.40 ppm±0.198). Komposisi fisikokimia mocaf dari genotipe G053 memiliki keunggulan yaitu karbohidrat, derajat putih tertinggi (98.44%±0.02) dan kadar air terendah (6.65%±0.004). Mocaf dari genotipe G390 memiliki protein (3.01%±0.018) tertinggi kadar abu (0.28%±0.002) dan lemak terendah (0.57%±0.004). Mocaf dari genotipe GX memiliki keunggulan dengan kadar rendemen tertinggi (28.57%±0.08) dan HCN terendah (0.20 ppm±0.10).
ENSINO REMOTO EMERGENCIAL NO MUNICÍPIO DE MONGAGUÁ, SP
Authors: Sehnem Edmar Lucas Ferreira , Martins Angela Maria
Published: March 2021

O processo de implementação de políticas públicas educacionais em esferas municipais exige reflexão sobre os inúmeros elementos que influenciam tal movimento de modo a garantir a qualidade da educação. O ano de 2020, em decorrência da pandemia de COVID-19 e consequente crise sanitária, foi acometido por fatores intervenientes de toda ordem, o que causou a necessidade iminente da implementação do ensino remoto a fim de preservar a saúde de alunos e suas famílias. As redes de ensino depararam-se com a urgência em adotar ações e estratégias que primassem por mitigar os impactos da pandamia na educação considerando seus contextos sociais, políticos e culturais conforme apontam estudos recém divulgados. Nessa direção, este artigo tem o propósito de analisar e discutir as ações e estratégias adotadas por escolas municipais na cidade de Mongaguá, localizada na baixada santista do Estado de São Paulo, a partir das orientações recebidas pelo Departamento de Educação Municipal (DEM).
Impacto do Confinamento na Saúde das Crianças e Adolescentes Durante a Pandemia de COVID-19
Authors: Peixoto Daniela , Leal Bárbara , Ribeiro Daniela , Correia Laura , Hipólito Elsa , Rocha Paula
Published: March 2021

N/a.
Placebo-controlled trials of Covid-19 vaccines – Are they still ethical?
Authors: Ortiz-Millán Gustavo
Published: March 2021

A World Health Organization (WHO) Ad Hoc Expert Group on the Next Steps for Covid-19 Vaccine Evaluation recently recommended placebo-controlled trials (PCT) of Covid-19 vaccines. PCTs are ethically acceptable when there is no proven effective and safe treatment for a certain condition. However, there are already some vaccines that have been approved and which have high levels of efficacy and safety. Any new vaccine under development must be tested against the most effective vaccines available. PCTs go against the participants’ best interests, by putting them in a position of disadvantage while taking part in a trial, compared with people who are not in the trial and who could get vaccinated. Particularly in high-income countries, many people are getting vaccinated. This means that, following a recent trend in clinical trials, PCTs would have to be conducted in low- and middle-income countries, where there a number of advantages for drug companies, but where fatality rates of Covid-19 are, in many cases, much higher. For this and other reasons having to do with equal rights, participants in control groups should be protected with the most effective vaccines available.
A Comparative Study of Health Disparities in Cervical Cancer Mortality Rates Through Time Between Black and Caucasian Women in Alabama and the US
Authors: Abdalla Ehsan , Habtemariam Tsegaye , Fall Souleymane , Troy Roberta , Tameru Berhanu , Nganwa David
Published: March 2021

Background: The main purpose of this study was to assess changes in cervical cancer mortality rates through time between Black and Caucasian women residing in Alabama and the US. Methods: Alabama cervical cancer mortality rates (MR), percentage differences, percentage changes and annual percentage changes for trends were compared with the US baseline and target rates. The US Baseline data and target objectives of utilization of cervical cancer screening and MR were obtained from Healthy People 2020. The cervical cancer behavioral risk factors and utilization of screening tests data were obtained from CDC’s Behavioral Risk Factor Surveillance System (BRFSS). The cervical cancer MR data were obtained from the Surveillance, Epidemiology, and End Results (SEER). The analysis was done using SEER*Stat and Linear Trendlines analysis. Results: Although Blacks in Alabama had higher cervical cancer MR through times, a decreasing trend was noted for both races. However, in Alabama, there is no significant change in Blacks aged 65 years and older in cervical cancer MR, despite a high screening rate compared to Whites. In contrast, between 2002 and 2012, Whites in Alabama and the US made a significant progress toward the Healthy People 2020 goal. Conclusions: In Alabama, there exists cervical cancer MR disparity in Blacks despite the higher rates of screening for cervical cancer as would otherwise be expected. The state has not yet achieved the Healthy People 2020 goal. Public health officials should monitor progress toward reduction and/or elimination of these disparities by focusing in a follow up of screening.
Students’ Math Self-Concept, Math Anxiety, and Math Achievement: The Moderating Role of Teacher Support
Authors: Oda Satoshi , Konishi Chiaki , Oba Takashi , Wong Tracy K. Y. , Kong Xiaoxue , Onge-Shank Chloe St.
Published: March 2021

This study explored the moderating roles of teacher instrumental and emotional support on the association between students’ math anxiety/math self-concept and math achievement. Participants included 21,544 Canadian students aged 15 years (10,943 girls) who participated in the 2012 Program for International Student Assessment. Results indicated that instrument support and emotional support were positively associated with math achievement. A significant moderation effect was evident between instrumental support and math anxiety; higher levels of instrumental support were associated with higher math achievement at low levels of math anxiety. Emotional support did not interact with math anxiety or math self-concept. The present findings highlight the importance to consider not only individual factors (i.e., math anxiety and math self-concept) but also the role of teacher support in supporting math achievement.
A Study on Non-Synonymous Mutational Patterns in Structural Proteins of SARS-COV-2
Authors: Das Jayanta , Roy Swarup
Published: March 2021

SARS-CoV-2 is mutating and creating divergent variants across the world. An in-depth investigation of the amino acid substitution in the genomic signature of SARS-CoV-2 proteins is highly essential for understanding its host adaptation and infection biology. A total of 9587 SARS-CoV-2 structural protein sequences collected from 49 different countries are used to characterize protein-wise variants, substitution pattern (type and location), and major substitution changes. The majority of the substitutions are distinct, occurred mostly in a particular location, and leads to a change in amino acid's biochemical properties. In terms of mutational changes, Envelope (E) and Membrane (M) proteins are relatively stable than Nucleocapsid (N) and Spike (S) proteins. Several co-occurrence substitutions are observed, particularly in S and N proteins. Substitution specific to active sub-domains reveals that Heptapeptide Repeat, Fusion peptides, Transmembrane in S protein, and N-terminal and C-terminal domains in N protein are remarkably mutated, and also found few deleterious mutations in these domains.
Plausible Blockers of Spike RBD in SARS-CoV2 – Molecular Design and Underlying Interaction Dynamics from High-Level Structural Descriptors
Authors: Basu Sankar , Chakravarty Devlina , Bhattacharyya Dhananjay , Saha Pampa , Patra Hirak K.
Published: March 2021

COVID-19 is characterized by an unprecedented abrupt increase in the viral transmission rate (SARS-CoV-2) relative to its pandemic evolutionary ancestor, SARS-CoV (2003). The complex molecular cascade of events related to the viral pathogenicity is triggered by the Spike protein upon interacting with the ACE2 receptor on human lung cells through its receptor binding domain (RBDSpike). One potential therapeutic strategy to combat COVID-19 could thus be limiting the infection by blocking this key interaction. In this current study, we adopt a protein design approach to predict and propose non-virulent structural mimics of the RBDSpike which can potentially serve as its competitive inhibitors in binding to ACE2. The RBDSpike is an independently foldable protein domain, resilient to conformational changes upon mutations and therefore an attractive target for strategic re-design. Interestingly, in spite of displaying an optimal shape fit between their interacting surfaces (attributed to a consequently high mutual affinity), the RBDSpike–ACE2 interaction appears to have a quasi-stable character due to a poor electrostatic match at their interface. Structural analyses of homologous protein complexes reveal that the ACE2 binding site of RBDSpike has an unusually high degree of solvent-exposed hydrophobic residues, attributed to key evolutionary changes, making it inherently ‘reaction-prone’. The designed mimics aimed to block the viral entry by occupying the available binding sites on ACE2, are tested to have signatures of stable high-affinity binding with ACE2 (cross-validated by appropriate free energy estimates), overriding the native quasi-stable feature. The results show the apt of directly adapting natural examples in rational protein design, wherein, homology-based threading coupled with strategic ‘hydrophobic ↔ polar’ mutations serve as a potential breakthrough.
Cerebral Organoids Derived from a Parkinson’s Patient Exhibit Unique Pathogenesis from Chikungunya Virus Infection when Compared to a Non-Parkinson’s Patient
Authors: Schultz Emily , Jones Tyanthony , Xu Sibei , Dean Dana , Zechmann Bernd , Barr Kelli L.
Published: March 2021

Arboviruses of medical and veterinary significance have been identified on all 7 continents with every human and animal population at risk for exposure. Like arboviruses, chronic neurodegenerative diseases like Alzheimer’s and Parkinson’s disease are found wherever there are humans. Viral parkinsonism has been documented for a variety of human pathogens though there are few studies that evaluate the effects of viral infection on degenerative neurological diseases. Significant differences in baseline gene and protein expression have been determined between Human Induced Pluripotent Stem Cell lines derived from a non-Parkinson’s disease individual and from an individual with reported Parkinson’s disease. While the organoids generated from each cell line were physically indistinguishable, significant differences were observed in gene and protein expression for neurotransmission and immunity. It was hypothesized that these inherent differences would impact cerebral organoid responses to viral infection. In this preliminary observational study, cerebral organoids from a non-Parkinson’s and Parkinson’s patient were infected with Chikungunya virus and observed for 2 weeks. Parkinson’s organoids lost mass and exhibited a dysfunctional antiviral response. Neurotransmission data from both non-Parkinson’s and Parkinson’s organoids had dysregulation of IL-1, IL-10, IL-6. These cytokines are associated with mood and could be contributing to persistent depression seen in patients following CHIKV infection. Both organoid types had increased expression of CCR5 and CXCL10 which are linked to demyelination, highlighting a potential mechanism for virus-associated parkinsonism. The dysfunctional antiviral response of Parkinson’s organoids highlights the need for more research in neurotropic infections in a neurologically compromised host.
Rethinking Climate, Climate Change, and Their Relationship With Water
Authors: Koutsoyiannis Demetris
Published: March 2021

We revisit the notion of climate, along with its historical evolution, tracing the origin of the modern concerns about climate. The notion (and the scientific term) of climate has been established during the Greek antiquity in a geographical context and it acquired its statistical content (average weather) in modern times, after meteorological measurements had become common. Yet the modern definitions of climate are seriously affected by the wrong perception of the previous two centuries that climate should regularly be constant, unless an external agent acted. Therefore, we attempt to give a more rigorous definition of climate, consistent with the modern body of stochastics. We illustrate the definition by real-world data, which also exemplify the large climatic variability. Given this variability, the term “climate change” turns out to be scientifically unjustified. Specifically, it is a pleonasm as climate, like weather, has been ever changing. Indeed, a historical investigation reveals that the aim in using that term is not scientific but political. Within the political aims, water issues have been greatly promoted by projecting future catastrophes while reversing the true roles and causality directions. For this reason, we provide arguments that water is the main element that drives climate and not the opposite.
A Novel Low-Risk Germline Variant in the SH2 Domain of the SRC Gene Affects Multiple Pathways in Familial Colorectal Cancer
Authors: Skopelitou Diamanto , Miao Beiping , Srivastava Aayushi , Kumar Abhishek , Kuświk Magdalena , Dymerska Dagmara , Paramasivam Nagarajan , Schlesner Matthias , Lubiński Jan , Hemminki Kari , Försti Asta , Bandapalli Obul Reddy
Published: March 2021

Colorectal cancer (CRC) shows one of the largest proportions of familial cases among different malignancies, but only 5-10% of all CRC cases are linked to mutations in established predisposition genes. Thus, familial CRC constitutes a promising target for the identification of novel, high- to moderate-penetrance germline variants underlying cancer susceptibility by next generation sequencing. In this study, we performed whole genome sequencing on 3 members of a family with CRC aggregation. Subsequent integrative in silico analysis using our in-house developed variant prioritization pipeline resulted in the identification of a novel germline missense variant in SRC gene (V177M), a proto-oncogene highly upregulated in CRC. Functional validation experiments in HT-29 cells showed that introduction of SRCV177M resulted in increased cell proliferation and enhanced protein expression of phospho-SRC (Y419), a potential marker for SRC activity. Upregulation of paxillin, β-Catenin and STAT3 mRNA levels, increased levels of phospho-ERK, CREB and CCND1 proteins and downregulation of the tumor suppressor p53 further proposed the activation of several pathways due to the SRCV177M variant. The findings of our pedigree-based study contribute to the exploration of the genetic background of familial CRC and bring insights into the molecular basis of upregulated SRC activity and downstream pathways in colorectal carcinogenesis.
Fly Ash Waste Recycling by Pt/TiO2 Incorporation for Industrial Dyes Removal
Authors: Visa Maria , Cosnita Maria , Moldovan Macedon , Marin Cosmina , Mihaly Maria
Published: March 2021

New materials are obtained by transforming fly ash wastes into a valuable composite, with tandem adsorption and photodegradation properties. Mild hydrothermal synthesis, from titanium dioxide, Platinum nanoparticles and zeolite materials obtained from a waste, fly ash, as support, was involved in the composite preparation. The Platinum nanoparticles extended the photocatalytic activity of the composite in Visible range (Eg = 2.1 eV). The efficiency of tandem adsorption and photocatalytic activity of the new composite were evaluated to 80.70% for Bemacid Blau and 93.89% for Bemacid Rot, after 360 min, the irradiation time, with H2O2 addition.
The Effect of Lockdown Period During Covid-19 Pandemic on Air Quality in Sydney Region, Australia
Authors: Duc Hiep , Salter David , Azzi Merched , Jiang Ningbo , Warren Loredana , Watt Sean , Riley Matthew , White Stephen , Trieu Toan , Tzu-Chi Chang Lisa , Barthelemy Xavier , Fuchs David , Nguyen Hubert
Published: March 2021

In early 2020 from April to early June, the metropolitan area of Sydney as well as the rest of New South Wales (NSW, Australia) experienced a period of lockdown to prevent the spread of Covid-19 virus in the community. The effect of reducing anthropogenic activities including transportation had an impact on the urban environment in term of air quality which is shown to have improved for a number of pollutants, such as nitrogen dioxides (NO2) and carbon monoxide (CO), based on monitoring data on ground and from satellite. Besides primary pollutants CO and NOx emitted from mobile sources, PM2.5 (primary and secondary) and secondary ozone (O3) during the lockdown period will also be analysed using both air quality data and modelling method. The results show that NO2, CO and PM2.5 levels decreased during the lockdown, but O3 instead increased. The change in the concentration levels however are small considering the large reduction in traffic volume of ~30%. By estimate the decrease in traffic volume in Sydney region, the corresponding decrease in emission input to the WRF-CMAQ (Weather Research and Forecasting - Community Multiscale Air Quality Modeling System) air quality model is then used to estimate the effect of lockdown on the air quality especially CO, NO2, O3 and PM2.5 in the Greater Metropolitan Region (GMR) of Sydney. COVID-19 lockdown period is an ideal case to study the effect of motor vehicle and mobile source contribution to air pollutants such as those listed above in the GMR.
Memory Generation and Re-Activation in Food Allergy
Authors: Koenig Joshua F.E. , Bruton Kelly , Phelps Allyssa , Grydziuszko Emily , Jiménez-Saiz Rodrigo , Jordana Manel
Published: March 2021

Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG+ memory B cells replenish pools of IgE-secreting cells upon allergen exposure, which contract thereafter due to the short lifespan of tightly regulated IgE-expressing cells. Advances in the detection and highly dimensional analysis of allergen-specific B and T cells from allergic patients have provided insight on their phenotype and function. The newly identified Th2A and Tfh13 populations represent a leap in our understanding of allergen-specific T cell phenotypes, though how these populations contribute to IgE memory responses remains poorly understood. Within, we discuss the mechanisms by which memory B and T cells are activated, integrating knowledge from human systems and fundamental research. We then focus on memory reactivation; specifically, on the pathways of secondary IgE responses. Throughout, we identify areas of future research which will help identify immunotargets for a transformative therapy for food allergy.