bluuebunny/crossref_metadata_2025 huggingface dataset:
Construction of Remote Patient Perceived Value Satisfaction Model with Online Medical Service for Specialties Based on ACSIM and TAM
Authors: Zhemin Zhang , Alturas Bráulio
Published: October 2022

With the development of medical treatment partnership and “internet + medical service” in China, this study proposes a remote patient perceived value satisfaction model (RPPVSM) with online medical service for specialties from the perspective of patient perceived value. Taking Shanghai Pulmonary Hospital Specialist Alliance (SPHSA) as the research subject, RPPVSM was constructed based on ACSI and TAM. Structural Equation Modeling (SEM) was modified to have a better degree of fitness and validation outcomes of the hypothesis as follows: Perceived ease of use has a significantly positive impact on perceived value with coefficient being 0.248; perceived usefulness has a significantly positive impact on the satisfaction with coefficient being 0.577; perceived value has a significantly positive impact on satisfaction with coefficient being 0.163. Perceived synergy has a significantly positive impact on perceived value with coefficient of 0.547; perceived ease of use will have a significantly positive impact on satisfaction through the perceived value variable with coefficient of mediation being 0.094; perceived synergy has a significant impact on satisfaction through perceived value with mediation coefficient being 0.196. The results suggest that the inclusion of the patient’s perception value index in the medical information platform is conducive to the construction of RPPVSM. Note: This study is not a clinical trial.
Student Survey After Ten Years of Continuous Blended Teaching of Echocardiocraphy
Authors: Parra Víctor M. , Fita Guillermina , Azqueta Manel , González Mauricio , Aranda Fernando , Maestre MaLuz , Silva Jorge , Hortal Javier , Morales Daniel , Bórquez Emiliano , Adasme Fabián , Real María Isabel , Mercadal Jordi , Zelada Pamela , Riobó Gonzalo , Galdames Katia , Domenech Raúl J.
Published: October 2022

Aims: The aim of this study is to analyze the impact of 10 years of blended learning in echocardiography.
Methods and results: A total of 140 of 210 medical doctors who graduated from our teaching program from 2011 to 2020 responded to the survey. Among them, 53,57% were anesthesiologists and 26,42% intensivists. More than 85% of respondents indicated that the online period met their expectations, and 70,2% that the hands on practice met the objectives. Posterior to the Diploma there was a significant increase in the frequency of use of echo compared to before the Diploma, both in transthoracic and transesophageal echocardiography, from 24,29% to 40,71% and from 13,57% to 27,86%, respectively. The echo was applied mainly in the perioperative period (56,7%) and in intensive care (32,3%), and only in 11% of cases it was used in emergency units. Additionally, 92,4% of respondents revealed that it was very useful in their subsequent professional practice and 92,47% that it helped them in the interpretation of echo reports.
Among the strengths they highlighted ‘the theoretical content, clinical cases, hands on activity and the teaching staff’. Among the weaknesses, 50% requested a practice period lasting more than one week.
Conclusion: The blended learning of echocardiography over a decade has been satisfactorily evaluated by the graduated specialists and has been related to a significant increase in its use in the perioperative period and in intensive care. The main challenges are to establish a longer period of practice and achieve greater scope in Emergency Medicine.
Bianchi type cosmological models with heat flow in Lyra’s geometry
Authors: R Santhikumar , B Satyannarayana , Kornu Suryanaryana P S , E Satyannarayana P
Published: October 2022

Bianchi type-V cosmological model along with perfect fluid and heat conduction have been discussed in the presence of Lyra’s geometry(1951 Lyra et al.). By using the law of variation for the mean Hubble parameter the solution contains heat conduction and gauge function for \(n=0 and n\ne 0\), which is related to the average scale factor of metric and gives decelerating parameter. We discussed heat transmission stages from initial time to the late time of the universe. The relation between density and pressure is discussed. We obtain a constant decelerating parameter. Physical interpretation and thermodynamic laws are discussed.
Preparing state within target topological sector of lattice gauge theory model on quantum simulator
Authors: Qiu Xingze , Yan Zheng , Zhou Zheng , Wang Yan-Cheng , Meng Zi Yang , Zhang Xue-Feng
Published: October 2022

Simulating lattice gauge theory (LGT) Hamiltonian and its nontrivial states by programmable quantum devices has attracted numerous attention in recent years. Rydberg atom arrays constitute one of the most rapidly developing arenas for quantum simulation and quantum computing. The Z2 LGT and topological order has been realized in experiments while the U(1) LGT is being worked hard on the way. States of LGT have local constraint and are fragmented into several winding sectors with topological protection. It is therefore difficult to prepare a state in certain sector for experiments, and it is also an important task for quantum topological memory. Here, we propose a protocol of sweeping quantum annealing (SQA) for searching the state within target topological sector. With the Monte Carlo method, we show that this SQA has linear time complexity of size with applications to the antiferromagnetic transverse field Ising model, which has emergent U(1) gauge fields. This SQA protocol can be realized easily on quantum simulation platforms such as Rydberg atoms and superconducting circuits. We expect this approach would provide a generic recipe for resolving the topological hindrances in quantum optimization and the preparation of quantum topological state.
Detection method of rail surface defects based on deep learning
Authors: Xu Jianming
Published: October 2022

For the detection of uneven and irregular texture surface defects, the conventional image reconstruction is difficult because the background texture is a nonstationary signal. At the same time, because it is difficult to obtain the image feature information such as the shape and gray level of defects in advance, and the visual features of similar defects can show great dispersion, the existing detection methods that rely on target features are difficult to apply. According to the vibration theory and transient finite element-boundary element theory, a method of analyzing and detecting rail fracture defects by using rail vibration response data is proposed. By establishing the dynamic model of vibration analysis of ballastless track, the characteristics of vibration acceleration of track under the condition of complete rail fracture and 50% fracture of rail section under the periodic load excitation of nodes are studied. In this paper, an unsupervised learning surface defect detection method based on image inpainting is proposed.In this method, a small number of normal texture sample images should be used as training sets to train the network model. Then, during detection, the missing region is artificially set in the sample image, and the content of the missing region is predicted by using the network model. Finally, according to the structural similarity evaluation and residual error between the reconstructed image and the image to be tested, the defect detection and separation are realized. Experimental results show that the algorithm has strong generalization ability, can accurately segment defects of tile images with large amount of complex texture, uneven illumination and low contrast, and has strong robustness.
Heart Disease Prediction System Using Convolutional Neural Networks
Authors: VARKALA KRISHNAIAH
Published: October 2022

In computer visualization. Deep learning affords effective outcomes for machine learning complications. Several techniques like minimum distance technique, K-Nearest neighbor algorithm, Naïve Bayes, Support Vector Machine, and Artificial Neural Network are used for the purpose of medical data classification. In this paper, heart disease data classification is performed using convolutional neural network. Generally convolutional neural network uses and applied in image data sets, but, in proposed method is used to calculate the accuracy of event for heart disease data sets. The experiments are passed out using heart disease data set of Uel machine learning repository. This trained classifier can classify the given data into either normal or abnormal of heart disease data.
The simultaneous degradation of prochloraz and tebuconazole in water with identification of the main degradation products using liquid chromatography-tandem mass spectrometry.
Authors: Awwad Mahmoud M. , taha sherif M , Khalil Mostafa M.H. , Salem Abdelnaby Mohamed , Chovelonc Jean-Marc
Published: October 2022

Prochloraz and tebuconazole are well-known fungicides for broad-spectrum applications, including; medical, industrial, and agricultural. These fungicides are frequently used simultaneously for the protection of various agricultural products. The presence of these fungicides in water doesn't only affect the health of direct consumers but also limits their reuse. In this study, complete degradation of these fungicides and their degradation products were accomplished using thermal-activated persulfate. It takes only 30 min to degrade 97% and 98% of PCZ and TBZ, respectively, in their single presence in water using 1.4 mM persulfate and a temperature of 50 ºC. However, in their simultaneous presence in water, a treatment for a complete one hour is required to degrade 99% and 94% for PCZ and TBZ, respectively, at the same degradation conditions. The persulfate degradation of prochloraz was conducted by the cleavage of the imidazole ring and the subsequent formation of a trichlorophenol. While, persulfate degradation of tebuconazole was mainly accomplished by the formation of a hydroxyl structure, cleavage of the tert-butyl chain, and the subsequent formation of a di-ketone degradation product. The identification of PCZ and TBZ degradation products was determined using the liquid chromatography-tandem mass spectrometry technique (LC-MS/MS) at both positive and negative modes. The suggested structures of these degradation products and their dissipation were confirmed and monitored, respectively, using efficiently developed LC-MS/MS multiple reaction monitoring methods.
Agreement between a swept-source ocular coherence tomography biometrer, a spectral-domain ocular coherence tomography biometrer, and an optical low coherence reflectometry biometer in eyes with cataract
Authors: Zarei-Ghanavati Saimak , Nikpayam Majid , Namdari Maral , Bakhtiari Elham , Hassanzadeh Samira , Ziaei Mohammed
Published: October 2022

Background
This study aimed to assess the agreement between biometric parameters measured by a spectral-domain OCT optical biometer device (Optopol Revo NX) with a validated Swept-source biometer (IOLMaster 700) and a validated optical low coherence reflectometry (OLCR) biometer (Lenstar LS 900), in cataract surgery candidates.
Methods
In this prospective comparative study, 100 patients (100 eyes) who were eligible for cataract surgery were involved. Bland Altman analysis was used to assess agreement between devices for biometric parameters including axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and central corneal thickness (CCT).
Results
AL measurements were successful in 82 eyes (82.0%) with Revo NX, in 91 eyes (91.0%) with Lenstar LS 900, and in 97 eyes (97.0%) with IOL Master 700. When Revo NX was compared to IOLMaster 700 and Lenstar LS 900, the mean differences were as follows: -0.02 ± 0.0.02 and − 0.02 ± 0.03 for AL, 0.01 ± 0.03 and 0.10 ± 0.03 (p < 0.05) for ACD, -0.15 ± 0.03 (p < 0.05) and 0.001 ± 0.04 for LT, and − 2.29 ± 0.92 (p < 0.05) and 0.73 ± 1.43 for CCT. There was a good correlation between devices for AL, ACD, LT, and CCT (ICC > 0.75). Bland-Altman analysis showed a narrower 95% limit of agreement (-0.35 to 0.31) between Revo NX and IOL Master 700 in measuring AL.
Conclusion
Despite the higher measurement failure rate in eyes with cataract, the Revo NX showed very good agreement with the IOL Master 700 and Lenstar LS 900 optical biometers in measuring AL, ACD, LT, and CCT. However, ACD and LT measurements can not be considered interchangeable between these devices.
BORN study: a multicenter randomized trial investigating cord blood RBC transfusions to reduce the ROP severity in extremely low gestational age neonates.
Authors: Teofili Luciana , Papacci Patrizia , Orlando Nicoletta , Bianchi Maria , Pasciuto Tina , Mozzetta Iolanda , Palluzzi Fernando , Giacò Luciano , Giannantonio Carmen , Remaschi Giulia , Santosuosso Michela , Beccastrini Enrico , Fabbri Marco , Valentini Caterina Giovanna , Bonfini Tiziana , Cloclite Eleonora , Accorsi Patrizia , Dragonetti Antonella , Cresi Francesco , Ansaldi Giulia , Raffaeli Genny , Villa Stefania , Pucci Giulia , Mondello Isabella , Santodirocco Michele , Ghirardello Stefano , Vento Giovanni
Published: October 2022

Background.
Extremely low gestational age neonates (ELGAN, i.e., neonates born before 28 weeks of gestation), are at high risk of developing retinopathy of prematurity (ROP), with potential long-life visual impairment. Due to concomitant anemia, ELGANs need repeated red blood cell (RBC) transfusions. These produce a progressive replacement of fetal hemoglobin (HbF) by adult hemoglobin (HbA). Furthermore, a close association exists between low levels of HbF and severe ROP, suggesting that a perturbation of the HbF-mediated oxygen release may derange retinal angiogenesis and promote ROP.
Methods/design.
BORN (umBilical blOod to tRansfuse preterm Neonates) is a multicenter double-blinded randomized controlled trial in ELGANs, to assess the effect of allogeneic cord blood RBC transfusions (CB-RBCs) on severe ROP development. Recruitment, consent and randomization take place at 10 Neonatology Intensive Care Units (NICUs) of 8 Italian tertiary Hospitals. ELGANs with gestational age at birth comprised between 24 + 0 and 27 + 6 weeks are randomly allocated into two groups: 1) standard RBC transfusions (adult-RBCs) (control arm); 2) CB-RBCs (intervention arm). In case of transfusion need, enrolled patients receive transfusions according to the allocation arm, unless an ABO/RhD CB-RBC is unavailable. Nine Italian public CB banks cooperate to make available a suitable amount of CB-RBC units for all participating NICUs. The primary outcome is the incidence of severe ROP (stage 3 or higher) at discharge or 40 weeks of post-menstrual age, which occurs first.
Discussion.
BORN is a ground-breaking trial, pioneering a new transfusion approach dedicated to ELGANs at high risk for severe ROP. In previous non-randomized trials, this transfusion approach was proven feasible and able to prevent the HbF decrease in patients requiring multiple transfusions. Should the BORN trial confirm the efficacy of CB-RBCs in reducing ROP severity, this transfusion strategy would became the preferential blood product to be used in severely preterm neonates.
Trial registration:
ClinicalTrials.gov Identifier: NCT05100212
A Dhdds K42E knock-in RP59 mouse model shows inner retina pathology and defective synaptic transmission
Authors: Nguyen Mai , Chakraborty Dibyendu , Rao Sriganesh Ramachandra , Onysk Agnieszka , Radkiewicz Mariusz , Surmacz Liliana , Swiezewska Ewa , Kraft Timothy , Sherry David , Fliesler Steven , Pittler Steven
Published: October 2022

Retinitis pigmentosa (RP) defines a group of hereditary progressive rod-cone degenerations that exhibit a common phenotype caused by mutations in over 70 genes. While most mutations in the dehydrodolichyl diphosphate synthase (DHDDS) gene result in syndromic abnormalities, some mutations cause non-syndromic RP (RP59). DHDDS encodes one subunit of the enzyme cis-prenyltransferase (CPT), which is required for the synthesis of dolichol (Dol), that is a necessary protein glycosylation cofactor. We previously reported the creation and initial characterization of a knock-in mouse model harboring the most prevalent RP59-associated DHDDS mutation (K42E) to understand how defects in DHDDS lead to retina-specific pathology. This model exhibited no profound retinal degeneration, nor protein N-glycosylation defects. Here, we report that the Dol isoprenylogue species in retina, liver, and brain of the K42E mouse model are shorter than in the corresponding tissues of age-matched controls, as reported in blood and urine of RP59 patients. Retinal transcriptome analysis demonstrated elevation of many genes encoding proteins involved in synaptogenesis and synaptic function. Quantitative retinal cell layer thickness measurements demonstrated a significant reduction in the inner nuclear layer (INL) and total retinal thickness (TRT) beginning at postnatal (PN) ∼2 months, progressively increasing to PN 18-mo. Histological analysis revealed cell loss in the INL, outer plexiform layer (OPL) disruption, and ectopic localization of outer nuclear layer (ONL) nuclei into the OPL of K42E mutant retinas, relative to controls. Electroretinograms (ERGs) of mutant mice exhibited reduced b-wave amplitudes beginning at PN 1-mo, progressively declining through PN 18-mo, without appreciable a-wave attenuation, relative to controls. Our results suggest that the underlying cause of DHDDS K42E mutation driven RP59 retinal pathology is defective synaptic transmission from outer to inner retina.
One step double augmentation with human dermis allograft and homologous PRP in misdiagnosed/chronic Achilles tendon ruptures.
Authors: Lughi Marcello , Moretti Cinzia , Ferretti Matteo , Bondioli Elena , Maitan Nicolò , Casadei Roberto
Published: October 2022

Background. Misdiagnosed/chronic Achilles tendon injuries are rare and disabling for patients. Surgical treatment of this type of injury guarantees optimal clinical and functional results by exploiting the proven regenerative potential of allografts of decellularized dermis and growth factors released from platelets concentrated in plasma. In this study, we mainly describe the surgical technique, original and not found in the literature, of using a biological graft (allograft of decellularized dermis) and homologous thrombin-activated PRP in a single step. Secondly, we evaluated results obtained at a minimum follow-up of 18 months and a maximum of 24 months. Methods. All patients of this study complained of pain, but above all of severe functional limitation that Achilles tendon injury had been causing for more than a month. Surgical approach, always used by the first author, respected predefined steps: careful dissection and preparation of the peritendinous tissues from suture to the end of the procedure, tenorrhaphy and augmentation with allopatch to obtain a mechanically effective repair to avoid recurrences, and finally 'biological' augmentation with a unit of homologous thrombin-activated PRP. We offered to all patients a regenerative rehabilitation program post-operatively. Results. All patients were evaluated clinically (functional clinical tests and questionnaires) and instrumentally (elastosonography and perfusion MRI). In all patients pain was resolved and district function and kinetic chains improved with resumption of daily activities, work and sports. Conclusions. The optimal results found confirm the regenerative potential of decellularized dermis allograft and PRP (homologous and thrombin-activated) in our study. This potential can also be exploited in cases of severe tendon destructuring and limited 'intrinsic' regenerative potential and at any age. The proposed one-step surgical technique of a double augmentation therefore appears useful, safe, reproducible and applicable in all chronic tendon lesions with low regenerative potential.
Epidemiological and therapeutic analyses of lung cancer patients in the Hokushin region: a retrospective hospital administrative database study
Authors: Kobayashi Takashi , Nishino Yoshikazu , Takiguchi Tomoya , Kanda Shintaro , Otsuki Kengo , Tanaka Yuriko , Nakazawa Yozo , Ito Ken-ichi , Hayashi Ryuji , Yasumoto Kazuo , Uramoto Hidetaka , Hirono Yasuo , Makino Tomoe , Nakada Mitsutoshi , Yano Seiji , Koizumi Tomonobu
Published: October 2022

Objective
This study was performed to validate the epidemiology, initial treatment, and clinical practice in lung cancer patients in the Hokushin region, Japan.
Methods
We surveyed retrospective data of newly diagnosed and registered lung cancer patients in 22 principal hospitals in Hokushin region linked with health insurance claims data for registered patients between 2016 and 2017.
Results
A total of 5503 lung cancer cases were newly diagnosed in Hokushin region during the study period. These patients consisted of 3677 (66.8%) men and 1826 (33.2%) women, with a median age of 72.2 years (range, 27 – 103 years). Diagnoses were small cell lung cancer in 512 (9.4%) cases, squamous cell carcinoma in 1083 (19.7%), and non-squamous non-small cell lung cancer in 3906 (70.9%). The population with stage I disease in Toyama prefecture (41.1%) was lower than in the other three prefectures associated with reduced selection of initial surgery therapy and increased frequencies of stage IV disease (33.2%) and best supportive care (18.6%). Initial chemotherapy for stage IV non-squamous NSCLC consisted of tyrosine kinase inhibitors in 39.3% of cases for EGFR and 4% of cases for ALK-positive non-squamous NSCLC, followed by platinum compounds (25.9%) non-platinum compounds (12.9%), and immune checkpoint inhibitors (10.2%). Carboplatin was the commonly prescribed first-line cytotoxic chemotherapeutic agent in 65.4% of patients under 75 years old and in 96.7% of patients over 75 years old.
Conclusion
This study revealed real-world data on epidemiological and treatment status in lung cancer in four prefectures in Hokushin region, Japan.
Carcinogenic and Non-carcinogenic Risk Assessment Induced by Pesticide Residues in Fresh Pistachio in Iran Based on Monte Carlo Simulation
Authors: Mahdavi Vahideh , Omar Sharaf S. , Zeinali Tayebeh , Sadighara Parisa , Fakhri Yadolah
Published: October 2022

This research is aimed at analysis 88 pesticides in 30 fresh pistachio samples prepared from stores in Iran by QuEChERS-Ultra-High Performance Liquid Chromatography-tandem mass spectrometry (UHPLC-MS/MS). The results showed at least one pesticide was in 67% of fresh pistachio samples. Kresoxim methyl residue was detected in 20 samples with average of 0.11 mg kg− 1, this average is 2.2 times more than MRL. buprofezin in 5 samples with average of 0.17 mg kg− 1 was observed with 3.4 times more than MRL, hexaconazole and permethrin were recognized in 3 samples lower than MRL with average residue of 0.030 and 0.028 mg kg− 1, respectively. In addition, potential non-carcinogenic and carcinogenic health risk assessments were evaluated using probabilistic methods performed with the Monte Carlo simulation algorithm. The order of pesticide ranking based on HQ was hexaconazole > buprofezin > permethrin > kresoxim methyl. Total HQ (HI) was 2.0E-4 and for children 9.0E-4 hence it means fresh pistachio consuming maybe not have significant short-term health risks for cosumers. Ranking based on CR was hexaconazole > kresoxim methyl > metalaxyl > permethrin > buprofezin. However, total CR due to pesticide residues was not higher than 1E-6 value (1.09E-9) therefore, consumers were not at significant risk of carcinogenicity in this product.
Social determinants of health and well-being among irregular migrant workers in Malaysia: A case study of Chin people from Myanmar
Authors: Khai Tual Sawn
Published: October 2022

Background
Malaysia is the second-most popular destination for regular and irregular migrant workers from Myanmar. They contribute to the economic prosperity of both the host and home countries; yet, their social determinants of health and physical well-being, particularly among irregular migrants remain neglected and unexplored. This study looked at how Myanmar irregular migrant workers' daily challenges, workplace exploitation and conditions, and coping strategies related to the social determinants of their health and well-being.
Methods
Two interview techniques were used in this study: semi-structured interviews with nine participants (n = 9), and three Focus Group Discussions with sixteen participants (n = 16). Participants were recruited through referrals from NGOs and snowball sampling due to the nature of the hidden population.
Results
The findings revealed that a variety of factors are affecting participants' health and well-being. Among the most pressing issues is their irregular immigrant status, which exposes them to various forms of exploitation and prevents them from accessing services. They suffer from depression, overthinking, worries about their families, and insomnia as a result of such conditions. Some relied on religious devotion (prayer), ignoring their sadness and dedication to support their families, while others relied on cohabitation or drinking alcohol, damaging their physical and mental health.
Conclusions
The findings suggest that Myanmar and Malaysian governments should collaborate to regularize existing irregular migrants in Malaysia and establish zero or low-cost recruitment policies to eliminate irregular migration for prospective workers since their labour contributions play a significant role in both countries' economies.
Yausa and M.Oleifera as natural coagulants for conventional water treatment
Authors: Gámez Lorena Salazar , Jojoa Edgar Narvaez , Cano Roberto Salazar
Published: October 2022

In Colombia there is a large gap between urban and rural areas in terms of the coverage of water and sanitation infrastructure. In 2018 there was a water supply system coverage of 87.6% in urban areas and 35% in rural areas. Some studies report that in 2017, 53.6% of the rural population did not have access to drinking water, given that these areas of the country are spread out in zones where conventional treatment systems are not adequate.
This study focuses on the color and turbidity removal performance of two natural coagulants at a given turbidity level; 40 – 50 NTU. The first of which, Moringa Oleifera, is widely known for its properties as a coagulant, and the other is Yausa (Abutilon Insigne Planch), a native plant species of Colombia that is used in an artisanal process of sugar extraction from sugar cane. Both natural coagulants were evaluated using a jar test procedure. Results showed that M. Oleifera and Yausa removed 90% and 93.6% turbidity respectively. For color removal, efficiencies of 95% and 85.3% were obtained respectively for M. Oleifera and Yausa.. Usage of natural coagulants (i.e M.Oleifera or Yausa) as opposed to chemical ones (i.e., alum), can be considered as an alternative for water treatment, especially in rural areas where the economic situation and access to chemical coagulants is difficult, and where the use of native species such as Yausa for industrial process is practiced.
Repeated Exposure to Lps Induces Sustained Neuroinflammation and Leptin Resistance
Authors: Silva Hellen Veida da , Debarba Lucas Kniess , Antunes-Rodrigues José , Elias Lucila Leico K.
Published: October 2022

Repeated exposure to lipopolysaccharide (LPS) was shown to induce leptin resistance. This study aimed to assess hypothalamic neuroinflammation in animals challenged with repeated injections of LPS. Male C57Bl6 mice were assigned into three different groups according to the following treatments: 7 daily injections of saline (CT); 6 daily injections of saline + 1 injection of LPS on the last day (1LPS, 5ug/animal), or 7 daily injections of LPS (7LPS). After the single injection of LPS, there was a reduction in food intake and body weight. However, after the third injection, the 7LPS animals did not show the hypophagic effect, characterizing the desensitization to the endotoxin. To assess the responsiveness to leptin, control and LPS-treated groups received a leptin injection (5mg/kg, intraperitoneal) and food intake and the expression of p-STAT-3 in the hypothalamus were determined. Leptin injection reduced food intake and increased STAT3 phosphorylation in the control group, but not in the 7LPS group. Exogenous leptin did not present an additional effect on the 1LPS-induced hypophagia. We also observed that the expression of SOCS3, PTP1B, and TCPTP, leptin signaling counter-regulators, were increased in the 7LPS group compared to the control, but not in the 1LPS group. Furthermore, we observed neuroinflammation characterized by morphological microglial changes in both acute and repeated exposure to LPS, compared to the control group. These data indicate that repeated exposure to LPS leads to neuroinflammation, and expression of leptin counteracting proteins that ultimately contribute to leptin resistance in the hypothalamus.
Evaluation of the effectiveness of common indoor plants in improving the indoor air quality of studio apartments
Authors: Sharma Shambhavi , Bakht Ahtesham , Jahanzaib Muhammad , Lee Hyunsoo , Park Duckshin
Published: October 2022

People spend most of their time indoors, and prolonged exposure to pollution can harm their health. The degradation of indoor air quality (IAQ) has raised serious issues. Botanical biofilters are an exciting solution for lowering indoor air pollution. However, plants cultivated inside under low light intensity (10–50 µ mole PAR m− 2 s− 1) generate CO2 in the indoor atmosphere. Combining C3 and CAM plants may be able to address this problem by lowering CO2 emission levels and enhancing the efficiency of pollution removal by removing the primary indoor air pollutants from actual interior settings, including Carbon dioxide (CO2), formaldehyde (HCHO), particulate matter (PM2.5 and PM10), and total volatile organic compounds (TVOCs). As a result, a successful botanical biofilter made of several plants was researched. Indoor plants can phytoremediate a variety of indoor contaminants. However, just a few studies have demonstrated its efficacy in practical contexts. Due to the harsh winter, apartments in South Korea are frequently closed, necessitating the measurement of interior air pollution concentration in real time. Four apartments (APT I through APT IV) with various ventilation and indoor plant setups were selected for this investigation. Various combinations of indoor environment (ventilation, low light) and a combination of C3 and CAM indoor plants as a botanical biofilter were used to study the sites over two months. Current research indicates that combining a botanical biofilter with ventilation can reduce levels of CO2, TVOCs, HCHO, PM2.5, and PM10 by 76%, 87%, 75%, 52%, and 51%, respectively. The current study concluded that different indoor potted plants provide an effective, affordable, self-regulating, sustainable option for enhancing indoor air quality and, consequently, human well-being and productivity in small, cramped places.
The non-vanishing imprint of gravitational waves as the result of its nonlinear evolution in the space
Authors: Gurwich Ioseph
Published: October 2022

In this paper, we consider the nonlinear self-interaction of gravitational waves and its results, which appear in the spectral space. Many authors widely consider different nonlinear effects, among them, in the frame of the concept of "gravitational memory." We begin the study by analyzing harmonic waves. Theoretical analysis shows that higher harmonics do not have suitable conditions for energy accumulation. But our study shows another exciting result. It predicts the transformation of gravitational wave energy into a non-vanishing deformation of the metric on the background space (zero harmonic or generated static field in our terminology). In other words, the waves leave their imprint on the background space. Moreover, this imprint does not disappear after the damping of the gravitational impulse. In addition, it gradually accumulates contributions from various sources. The path of the Primordial Gravitational Wave is much weaker than in galaxies, and the static field created in the latter can be associated with additional mass. In this study, we evaluate the effects numerically.
PACS. PACS-key 04.30.Nk
Comparison and Parallel Implementation of Alternative Moving-Window Metrics of the Connectivity of Protected Areas Across Large Landscapes
Authors: Hughes Josie , Lucet Valentin , Barrett Griffin , Moran Scott , Manseau Micheline , Martin Amanda E. , Naujokaitis-Lewis Ilona , Dastis Jorge Octavio Negrín , Pither Richard
Published: October 2022

Context.
A variety of metrics can be used to measure connectivity of protected areas. Assumptions about animal movement and mortality vary among metrics. There is a need to better understand what to use and why, and how much conclusions depend on the choice of metric.
Objectives.
We compare selected raster-based moving-window metrics for assessing the connectivity of protected areas to natural habitat in the surrounding area, and develop tools to facilitate calculation of these metrics for large landscapes.
Methods.
We developed parallel implementations of distance-weighted sum and Spatial Absorbing Markov Chain methods in R packages to improve their useability for large landscapes. We investigated correlations among metrics for Canadian protected areas, varying background mortality, cost of movement, mean displacement, dispersal kernel shape, distance measure used, and the treatment of natural barriers such as water, ice, and steep slopes.
Results.
At smaller spatial scales (2–5 km mean displacement), correlations among metric variants are high, suggesting that any of the metrics we investigated will give similar results and simple metrics will suffice. Differences among metrics are most evident at larger spatial scales (20–40 km mean displacement) in moderately disturbed regions. Assumptions about the impact of natural barriers have a large impact on outcomes.
Conclusions.
In some circumstances different metrics give similar results, and simple distance-weighted metrics likely suffice. At large spatial scales in moderately disturbed regions there is less agreement among metrics, implying that more detailed information about disperser distribution, behaviour, and mortality risk is required for assessing connectivity.
6-phosphofructo-2-kinase is a potential prognostic gene in gastric cancer and associated with immune infiltration
Authors: Lei Lan , Lan Yu-yin , Chen Li-Ting , Wu Zhi-Bing
Published: October 2022

Background
Gastric cancer is a common malignant tumor of digestive system with high morbidity and mortality. Reprogramming of glucose metabolism plays an important role in the occurrence and immune infiltration of gastric cancer.PFKFB3 is an efficient allosteric activator of glycolysis.Therefore, an in-depth understanding of PFKFB3 expression in the gastric cancer microenvironment and its effect on immune cells may help to find new ways to combat gastric cancer, thereby promoting existing therapeutic therapies.
Methods
We evaluated the expression of PFKFB3 in gastric cancer, its relationship with immune invasion and the value of clinical prognosis by a series of databases such as TCGA (Cancer Genome Atlas) and GEO (Gene Expression Omnibus) and in vitro and in vivo experiments.
Results
PFKFB3 was overexpressed in gastric cancer, up-regulation of PFKFB3 usually predicted poor prognosis, and high PFKFB3 expression in gastric cancer was significantly associated with poor overall survival (OS) and progression-free survival (PFS)).In addition, high expression of PFKFB3 correlates with immune cell infiltration and associated immune markers in the gastric cancer microenvironment.In vitro and in vivo experiments showed that high expression of PFKFB3 could promote the growth and metastasis of gastric cancer cells, and PFKFB3 antagonist treatment could delay the growth of gastric cancer cells.
Conclusion
High expression of PFKFB3 leads to poor prognosis of gastric cancer, that is, shorter OS and PFS.PFKFB3 is associated with levels of immune infiltration in gastric cancer patients, including B cells, CD4 + T cells, CD8 + T cells, and macrophages.The results showed that PFKFB3 was associated with immune infiltration and could be used as a potential biomarker to predict the prognosis of gastric cancer.In addition, PFKFB3 expression may contribute to the regulation of gastric cancer macrophages, CD8 + T cells, TAM, Th1 cells and Treg, and is a potential biomarker for gastric cancer treatment, revealing the correlation between glucose metabolism reprogramming and gastric cancer immunotherapy.
The effect of ocular melanin density on human vision
Authors: Pirgourabi Parmida
Published: October 2022

Background: Without discussing the effect of ocular melanin density on vision, let us make the logical assumption that since melanin is a protective factor for the eye, its lower density causes more sunlight to damage vision cells. The question is not how the melanin density of the eye affects vision, but how the melanin density of the eye affects vision. The purpose of this manuscript is to try to answer this question.
Results: After the test, it was found that in lighter eye color, due to the lower density of melanin, less protection against the sun’s rays is provided to the vision cells, which caused the destruction or damage to the vision cells and makes the person perceive colors darker than people see that the density of melanin in the eyes is higher.
Conclusion: the color of each person’s eyes indicates the density of melanin in the eye, the lighter it is, the lower the density of melanin in the eye, and since the melanin in the eye has a protective role for the vision cells against solar rays, the lower its density, the more severe the damage from solar rays. The visual cells, especially the cylindrical ones, are increased and may affect the person’s vision.
Utility of Apneic Oxygenation with Intubation to Reduce Severe Desaturation and Adverse Tracheal Intubation Associated Events in Critically Ill Children
Authors: Napolitano Natalie , Polikoff Lee , Edwards Lauren , Tarquinio Keiko , Nett Sholeen , Krawiec Conrad , Kirby Aileen , Salfity Nina , Tellez David , Krahn Gordon , Breuer Ryan , Parsons Simon J. , Page-Goertz Christopher , Shults Justine , Nadkarni Vinay , Nishisaki Akira
Published: October 2022

Background
Determine if apneic oxygenation (AO) delivered via nasal cannula during the apneic phase of tracheal intubation (TI), reduces adverse TI-associated events (TIAEs) in children.
Methods
AO was implemented across 14 pediatric intensive care units (ICUs) as a quality improvement intervention during 2016–2020. Implementation consisted of an intubation safety checklist, leadership endorsement, local champion, and data feedback to frontline clinicians. Standardized oxygen flow via nasal cannula for AO were as follows: 5 liters/minute for infants (< 1 year), 10 liters/minute for young children (1–7 years), and 15 liters/minute for older children (≥ 8 years). Outcomes were the occurrence of adverse TIAEs (primary) and hypoxemia (SpO2 < 80%, secondary).
Results
Of 6,549 TIs during the study period, 2,554 (39.0%) occurred during the pre-implementation phase and 3,995 (61.0%) during post-implementation phase. AO utilization increased from 23–68%, p < 0.001. AO was utilized less often when intubating infants, those with a primary cardiac diagnosis or difficult airway features, and patient intubated due to respiratory or neurological failure or shock. Conversely, AO was used more often in TIs done for procedures and those assisted by video laryngoscopy. AO utilization was associated with a lower incidence of adverse TIAEs (AO 10.5% vs without AO 13.5%, p < 0.001), aOR 0.75 (95% CI 0.58–0.98, p = 0.03) after adjusting for site clustering (primary analysis). However, after further adjusting for patient and provider characteristics (secondary analysis), AO utilization was not independently associated with the occurrence of adverse TIAEs: aOR 0.90, 95% CI 0.72–1.12, p = 0.33. The occurrence of hypoxemia was not different: AO 14.2% vs without AO 15.2%, p = 0.43.
Conclusion
AO utilization was associated with a lower occurrence of adverse TIAEs in patients undergoing TI in the pediatric ICU.
Oxidation of Alcohols to Carbonyl Compounds Catalyzed by Reusable Manganese Porphyrin under Mild Aqueous Conditions
Authors: Sokhandan-Koirim Zahra , Ghorbanloo Massomeh , Mokary-Yazdely Tahere
Published: October 2022

The present study aims to introduce a new catalytic system, namely poly[(2-acrylamido-2-methyl-1-propane sulfonic acid-co-acrylonitrile)-Mn(III) meso tetra(N-methyl-4-pyridyl) porphine briefly called p(NaAMPS-co-AN)‐[Mn(TMPyP)]. Free-radical polymerization at ambient temperature was employed to construct this catalytic system. To prepare this heterogeneous bi-phasic catalyst, poly(NaAMPS-co-AN) was axially grafted onto the metal centers of the MnIII composite. In order to identify the amounts of metals in prepared compound, atomic absorption spectroscopy (AAS) was utilized. The results indicated that p(NaAMPS-co-AN)‐[Mn(TMPyP)] had the potential to efficiently catalyze alcohol oxidation with high selectivity in the solid-liquid biphasic reaction system. Furthermore, the catalytic activities of alcohol oxidation by the reaction-controlled phase transfer catalyst system were compared in the presence of H2O2 and TBHP, as oxidants, in a biphasic environment. It was found that functioning as a nanoreactor, the prepared catalyst system facilitated the oxidation of alcohols in water, leading to the substantial acceleration of catalytic reaction rates. After the completion of the catalytic activity, the catalyst could be separated easily from the reaction media and reused without any activity loss. In effect, the quality of the catalyst remained the same for eight cycles. The excellent performance of p(NaAMPS-co-AN)‐[Mn(TMPyP] is mostly attributed to its macroporous structure which allow for a rapid diffusion of the reactants to the reactive Mn(III) centers. High stability and reusability of catalyst without leaching is may be due to the AN. In fact, p(NaAMPS-co-AN)‐[Mn(TMPyP)] has chemical cross-linker, MBA, and physical cross-linker, AN. In a similar vein, the FT-IR spectra and atomic absorption spectroscopy confirmed the great recyclability, durability, and leaching resistance of the catalyst.
Diversity and Abundance of Avifauna: Implications for Conservation and Ecotourism Development in Suba Forest, Central Ethiopia
Authors: Tassie Nega , Dejene Sintayehu W. , Elphick Chris , Mosisa Gemechis B.
Published: October 2022

Background: Birds are among essential taxa in various ecosystems where their presence/absence and status indicate conditions of the habitats. Bird watching can bring economic resources to communities diversifying their livelihoods and contributing to biodiversity conservation in areas of bird habitats. Hence, a detailed understanding of species biogeography, diversity, and abundance is critical ecological information to evaluate or develop conservation strategies. The present study was conducted to assess species diversity and abundance of avifauna during wet and dry seasons of 2021 implications for conservation and ecotourism development in the Suba forest, Central Ethiopia. Stratified random sampling technique was utilized to select sampling blocks from each habitat type. Data were collected using lines transect and points transect count methods. Diversity of the species was computed using the Simpson's and Shannon-Weiner diversity indices. A two-way ANOVA was applied to know the effect of habitat and seasonality on avian species richness and abundance.
Results: A total of 132 birds belonging to 51 families were identified during the study period. Among the recorded bird species, 124 were found to be residents. Four were endemic to Ethiopia, six were endemic to Ethiopia and Eritrea, and seven were globally threatened. The highest, H' = 4.569, and the lowest, H' = 3.935, of bird species was observed in natural forest and farmland habitats during the wet and dry seasons, respectively. Approximately half of the recorded species were found to be common. The difference in habitat type and variation in the season had substantial effects on the species abundance and richness. Plantation forest and farmland habitats had more worth mentioning community similarity. The forest has frequently been visited by domestic tourists than foreign non- resident and foreign resident tourists in the last 10 years.
Conclusions: Suba forest is abundant in avifaunal resources with high ecotourism potential but lacks functioning conservation efforts and research. Thus, effective conservation measures and further research in other aspects of the forest are required.
First steps to study the demography of vascular epiphytes in cities
Authors: Mondragón Demetria , Mora-Flores Martha Patricia
Published: October 2022

Urban ecosystems could jeopardize the existence of vascular epiphytes (VS), given that their occurrence is linked to phorophyte availability and particular climatic conditions. Despite reports of VS in cities, nothing is known about their demography. A first step in this direction is to describe their population structures (PS). We established the PS of VS present in urban parks in Oaxaca City, addressing the following questions: what is their demographic status? and are there differences in the structure of populations growing in native versus exotic phorophytes? During 2021, we censused all the trees in six urban parks, recording their origin (native or exotic), the epiphytic species found on them and the development stages present in each VS population. Overall, five VS species were documented:Tillandsia ionantha,T. makoyana,T. sp,T. recurvataandT. schiedeana; the first three with only one individual and the latter two with 5,694 and 95, respectively. A MANOVA test indicated significant differences in PS betweenT. recurvata(type I structure, suggesting a growing population) andT. schiedeana(type III structure, suggesting a senile population) (Wilkes' λ = 0.821, F-Radio = 11.96 P < 0.001). PS showed no differences related to tree origin. Our results indicate that it is necessary to conduct demographic studies to have a more accurate idea of the current condition of vascular epiphytes in cities. For instance, even though we found five VS species, only one of them seems to have viable populations in Oaxaca city.
GPR137 promotes cell cycle exit and neuronal differentiation in the neuro2A cells
Authors: Iwasa Kensuke , Yamagishi Anzu , Yamamoto Shinji , Haruta Chikara , Maruyama Kei , Yoshikawa Keisuke
Published: October 2022

The orphan receptor, G protein-coupled receptor 137 (GPR137), is an integral membrane protein involved in several types of cancer. GPR137 is expressed ubiquitously, including in the central nervous system (CNS). We established a GPR137 knockout (KO) neuro2A cell line to analyze GPR137 function in neuronal cells. KO cells were generated by genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and cultured as single cells by limited dilution. Rescue cells were then constructed to re-express GPR137 in GPR137 KO neuro2A cells using an expression vector with an EF1α promoter. GPR137 KO cells increased cellular proliferation and decreased neurite outgrowth (i.e., a lower level of neuronal differentiation). Furthermore, GPR137 KO cells exhibited increased expression of a cell cycle regulator, cyclin D1, and decreased expression of a neuronal differentiation marker, Neuro D1. Additionally, GPR137 KO cells exhibited lower expression levels of the neurite outgrowth markers STAT3 and GAP43. These phenotypes were all abrogated in the rescue cells. In conclusion, GPR137 deletion increased cellular proliferation and decreased neuronal differentiation, suggesting that GPR137 promotes cell cycle exit and neuronal differentiation in neuro2A cells. Regulation of neuronal differentiation by GPR137 could be vital to constructing neuronal structure during brain development.