bluuebunny/crossref_metadata_2025 huggingface dataset:
Student Perspectives in Investing in Stocks to Grow Interest in Investing in the Investment Gallery of the Indonesia Stock Exchange Universitas Muhammadiyah Sidoarjo According to an Islamic View
Authors: Sholihah Noviatus , Hariyanto Wiwit
Published: September 2021

Knowledge of stock investment can encourage someone to have a positive attitude so that it fosters student interest in investing. Students are also still wondering whether the investment is a halal transaction or not. The purpose of this study is to find out how the perspective of students in investing in stocks according to the Islamic view to foster interest  investing in the IDX, Umsida.

             In this study, the method used is a qualitative method with data collection techniques carried out by interviews, observation and documentation. Informants in this study is students.

             The results of this study indicate that students who have invested in students have 3 symptoms, namely elements of knowledge, will and feelings. Meanwhile, students who have not invested already have one of the symptoms of 3 elements. The student's perspective in growing interest in investing according to the Islamic view is to increase knowledge about investment.
Ulama Sebagai Legitimator Informasi Keuangan Masyarakat Perdesaan Di Era Digital
Authors: Mirawati Ira , Sugiana Dadang
Published: September 2021

At the end of 2016, Muslim religious leaders are under the spotlight in relation to the success of 411 and 212 action calls that demand a judgment on Basuki Cahaya Purnama. This event shows that in this era of digital media, Muslim religious leaders still have an influence to mobilize the masses. Therefore, scholars need to be considered to participate to successing the development programs and become agents of change in the diffusion of innovation. Rural communities need ulama as opinion leaders or information legitimators, especially in the era of digital media that is developing today. Ulama is important to increase knowledge of rural communities including the field of finance and banking.Our Public Service Programme performed in Desa Cikondang, Kecamatan Cibeber, Kabupaten Cianjur Jawa Barat. In this location there are financial problems in the form of "mobile bank" which is the camouflage of moneylender activity.  The program is done in three stages, mapping the digital media access of ulama, mapping the moneylender problem, and mapping the role of ulama in overcoming the problem by utilizing digital media.
Strategi Talent Management Pada Usaha Kecil Dan Menengah Dalam Meningkatkan Daya Saing Bisnis
Authors: Nawangsari Lenny C , Sutawidjaya Achmad H
Published: September 2021

Dynamic business conditions, uncertainty and complexity require Small and Medium Enterprises (SMEs) to improve their strategy to exist in the business world. One of the important factors in business competition is the qualified Human Resources (HR). The good Management of  human resource talent will be an added value for business competition. This study aims to analyze talent management strategies in SMEs to improve business competitiveness. The research methodology used a qualitative approach using case study. Data obtained through interviews and field observations on 5 key informants in SMEs belonging to members of PAUB (Women Interfaith) in Malang. The results of the study found that the SME management talent strategy consists of talent planning, talent recruitment, Talent Development and Talent Retaining. Talent Management strategy development should pay attention to corporate strategy and external environment that affect the condition of SMEs. Talent Management Strategy if applied properly is expected to improve SME productivity and profitability so that will lead to SME business continuity.
Pengembangan Usaha Ikan Salai Patin Di Desa Pulau Gadang, Riau
Authors: Afrinis Nur , John Taruna , Nislawaty Nislawaty
Published: September 2021

The service has been carried out in the PKK Women's Group, the residents of Turi Hamlet, Turirejo Village, Kedamean District, Gresik Regency. The service is carried out for 1 month starting from August to September 2017. The aim is to help PKK residents of Dusun Turi especially women in determining the Cost of Goods Sold in Entrepreneurship so that they can calculate all the costs that have been used while running the business and also for know how much the amount of profit and loss during running the business. Small and medium enterprises (UKM) are businesses that start from family or home businesses. By making corn brownies as SMEs, they can earn their own income by utilizing farmers' crops such as corn which can be processed into food, namely corn brownies. By making corn brownies as SMEs, this dedication tries to help PKK residents of Turi Hamlet, especially mothers, in determining the cost of sales that can be applied to corn brownies UKM.
Strategi Supply Chain Usaha Kecil dan Menengah (UKM) Dalam Menghadapi Pasar Bebas (Studi Kasus PAUB, Malang, Indonesia)
Authors: Sutawijaya Ahmad Hidayat
Published: September 2021

This article puts forward the strategy of supply chain strategy for small and medium enterprises (called SMEs) in developing the network during their business period which network is needed and will change from time to time. Successful implementation of supply chain management (SCM) can give SMEs an advantage over their competitors. Problems that occur for SMEs in Indonesia and other developing countries face problems in the implementation of SCM due to lack of resources and direction. To compete effectively in global markets, SMEs must have effective supply chain management and thus require comprehensive strategic planning in an effort to develop the SME business group itself. This research methodology used qualitative approach through interview approach and field study to group members of Women Interfaith Among Religious (PAUB), Malang city. The results of field studies show that integrated small and medium enterprise (SME) supply chain strategy planning contribute to the success of SMEs for PAUB members of Malang city. The supply chain strategy planning process that SMEs need has stages like "source," "create," and "deliver". Thus, when implemented it will connect with various supply chain cycles such as "ordering," "procurement," "production," "distribution," and "customer" for SME groups.
Pengembangan Kapasitas Ekonomi Berbasis Masyarakat Di Desa Wisata Cibuntu, Indonesia
Authors: Bahri Asep Syaiful , Suyatno Rianto
Published: September 2021

The process of planning and decision making in the development program for this is oftenly done by top-down. Most often society is not given a choice and an opportunity to provide input. Sometimes government assistance creates dependency, which in turn would create trouble than help. The purpose of this study was to illustrate the potential of tourism and economic potential in the Cibuntu village as well as to determine the model to improve the local economy based on tourism. Samples are some families in the Cibuntu village. The results of this study indicate that the tourism  and economic potential are very diverse and can support tourism activities and for the community-based model of economic improvement which can be implemented is culinary-based, homestay based and craft-based.
Pemberdayaan Konselor Sebaya di MTs Darussalam Taman dan MTs Muhammadiyah 1 Taman Sidoarjo
Authors: Arifin Moch. Bahak Udin By , Fahyuni Eni Fariyatul
Published: September 2021

Peer counseling is counseling assistance which provided by peers who have been given training to be peer counselors, so that they can provide assistance both individually and groups. Guidance assistance is given to friends who have problems or who has various obstacles in the development of their personality. Peer counselors will provide positive reinforcement because peers have a large influence on individual behavior changes. The purpose of this service is to provide training to students who are given the authority as peer counselors in MTs Darussalam Taman and MTs Muhammadiyah 1 Taman to improving the effectiveness of teacher counseling guidance services. The steps in this service are: First, make observations to each school which is the aim to get an overview of the object, its includes the profile of the school, the number of students, the availability of counseling guidance staff, and information about student problems. Second, collaborating with counseling and classroom teacher teachers, selecting 30 students from grades VII and VIII in each school to become peer counselors. Third, conducting peer counselor training with lecture, question and answer, role play and simulation methods. Fourth, the concelor counseling follows up with mentoring and evaluating, the counseling process carried out by peer counselors. The results of this service are the increasing effectiveness of counseling services through peer counselors in Darussalam Taman MTs and MTs 1 Muhammadiyah Taman.
Analisis Sistem Informasi Akuntansi Penggajian Pada CV ABC di Jawa Tengah
Authors: Pramesti Wahyu , Trijayanti Desi
Published: September 2021

This research was conducted at CV ABC which is engaged in the furniture industry. In managing the payroll system this company is still less effective. It can be seen from several salary payment activities to employees who still often make mistakes in the process of calculating salaries and employee attendance records. In addition, in the process of paying salaries to employees, they often experience late payments. The purpose of this study is to analyze the payroll accounting information system in the company which is expected to help resolve the problems faced by the company. The research method used in this study is a qualitative descriptive research method. The thing that will be done by the researcher is to describe the use of payroll accounting system on CV ABC. The conclusion of this study is that the payroll system on CV ABC is already good because it has used a computerized system. The internal control in the payroll process is still weak because there are still division of tasks and responsibilities of each part that is unclear, namely there is a double duty and interdependence in working tasks, besides that supervision is still lacking for activities that should be routinely checked or corrected.
Pengetahuan Dewan Tentang Anggaran Dalam Pengawasan Keuangan Daerah (APBD) Di Kabupaten Sidoarjo
Authors: Dewi Santi Rahma , Sinduwiatmo Kukuh , Biduri Sarwenda
Published: September 2021

This study aims to find out how the board's knowledge about the budget in implementing regional financial supervision (APBD).This research was conducted with qualitative methods by presenting elements of questions regarding the board's knowledge of budget and regional financial supervision. Methods of gathering information using interviews and documentation to members of the Sidoarjo Regency council.The results of this study indicate that board members understand the process of determining the budget carried out by the executive, so that they can supervise and control the implementation of the APBD in Sidoarjo Regency. And expect follow-up from the executive on recommendations that have been given by the legislature where so far there has been no follow-up done
American Productivity Center (APC) and Craig-Harris Productivity Model method in measuring the productivity of customs companies
Authors: Ardianto Ricky , Jakaria Ribangun Bamban
Published: September 2021

The purpose of this study is centered on measuring the total and partial productivity of customs companies using the American Productivity Center (Apc) Method and the Craig-Harris Productivity Method where the difference between the two is the Craig-Harris Productivity Method directly measures the level of total efficiency obtained from company growth. overall while the American Productivity Center (Apc) method is a measurement to determine the level of the productivity index, profitability and price improvements. The results obtained from measurements in 2018 to 2019 for twenty-four periods are the productivity index of the APC model, the largest decrease in index occurred in capital input in April 2019, which decreased by 22.06%, while with the Craig-Harris Method the largest decrease in productivity figures occurred in power input. Employment in June 2019 decreased by 25.077% from the initial period. From the results of the two methods, there are differences in measurement results, namely the largest decrease in APC occurs in the Capital variable, while the largest decrease in the Craig-Harris Method occurs in Labor and the smallest decrease in productivity occurs in Material input.
Arduino Based Turkey Egg Incubator With Molen Rotation Method
Authors: Prayugo Ardi , Syahrorini Syamsudduha
Published: September 2021

Today's modern world of hatching many turkey eggs uses various incubators. Arduino-based turkey egg incubator with the molen rotation method uses an Arduino microcontroller that is connected to a DHT11 sensor for turkey egg incubator using the molen rotation method. Temperature and humidity are the main factors to determine the success at hatching of eggs, but also the need for the fertilization process in the eggs to be hatched because fertilization also determines the success rate at hatching eggs. Testing of the incubator is carried out directly from the turkey egg incubator at the temperature in the room and rotates it with the automatic spinning method with an angle of 360 ° every 4 hours. DHT11 can detect temperature and humidity in the incubator room, the optimal temperature for hatching turkey eggs is 37 ° -38 ° C and the optimal humidity is 55-60% RH, and the servo motor is able to move to move the egg rack according to the time specified. The measurement results of the DHT11 sensor readings are as desired with a minimum temperature reading of 37⁰C and a maximum temperature of 39⁰C with humidity that has been set at 55-60% and the molen rotation method runs according to the desired time every 6 hours for 4 times with 360 ⁰ rotation, at days 1-26 turkey eggs hatch with a result of 3: 2 in the sense that 3 successfully hatched and 2 failed to hatch.
Knowledge Base Design for Diagnosis Pregnancy Problems
Authors: Arzumni Farah Rifdah , Indahsari Rina Dewi
Published: September 2021

In Indonesia, the death rate of pregnant women was still very high. Lack of knowledge about the perceived symptoms during pregnancy make pregnant women regardless of the specific symptoms that can be harmful and disease records indicate the causes of indirect maternal death in pregnant.  Moreover, the risk of pregnant mother mortality is also higher due to the delay in taking the decision factors for referenced. Based on the fact, the proposed solution in the form of expert system diagnosis of diseases of pregnant women using the method of Backward Chaining that can help recognize diseases during pregnancy to take place based on the perceived symptoms of pregnant women as well as references that should be targeted by the patient. The methods of the Backward Chaining have a performance system that is capable of running the functional needs and high accuracy percentage results. With the existence of a system of experts on pregnancy problems that use the Backward Chaining method can describe the level of confidence of an expert on the problem at hand. Based on the test results, obtained results 100% functionality of disease diagnosis expert system of pregnant women worked in accordance with a list of system requirements and the system.
Effect of Drying Temperature on Sensory Properties of Mustard Flour (Brassica juncea) Using Oven Dryer
Authors: Ekawati Yeny , Saidi Ida Agustina
Published: September 2021

This study aims to determine the effect of drying temperatures on sensori properties of mustard greens flour. The study was conducted from February to April 2020. Hedonic test used non-parametric statistical to determine sensori properties of mustard greens flour.The sample used was mustard greens (Brassica juncea) from Waru, Sidoarjo. Various temperature used oven  drying at 40oC, 50oC,60oC and 70oC. The results showed that the drying temperatures has not difference on hedonic test of color, aroma, and texture of mustard flour.
International Guidelines on Natural and Nature-Based Features for Flood Risk Management
Authors: Bridges Todd , King Jeffrey , Simm Johnathan , Beck Michael , Collins Georganna , Lodder Quirijn , Mohan Ram
Published: September 2021

To deliver infrastructure that sustain our communities, economy, and environment, we must innovate, modernize, and even revolutionize our approach to infrastructure development. Change takes courage, but as one starts down the path of innovation, what was once novel becomes more familiar, more established. The U.S. Army Corps of Engineers (USACE) is walking this path with our partners through the Engineering With Nature (EWN) Initiative, integrating human engineering with natural systems. The International Guidelines on Natural and Nature-Based Features for Flood Risk Management are the next step toward revolutionary infrastructure development—a set of real-world guidelines to help familiarize us with what was once novel. USACE and collaborators around the world have been building, learning, and documenting the best practices for constructing Natural and Nature-Based Features (NNBF) for decades. The consolidation of these lessons into a single guidance document gives decision-makers and practitioners a much-needed resource to pursue, consider, and apply NNBF for flood risk management while expanding value through infrastructure. Relationships and partnerships are vital ingredients for innovation and progress. The NNBF Guidelines was achieved because of the strong relationships in the nature-based engineering community. The magnitude and diversity of contributors to the NNBF Guidelines have resulted in a robust resource that provides value beyond a single agency, sector, or nation. Similarly, the work of incorporating NNBF into projects will require us to strengthen our relationships across organizations, mandates, and missions to achieve resilient communities. I hope you are inspired by the collaborative achievement of the NNBF Guidelines and will draw from this resource to develop innovative solutions to current and future flood risk management challenges. There is a lot we can achieve together along the path of revolutionary infrastructure development.
An Overview of Labor Pain: Components and Stages of the Labor Process
Authors: El-Sakhawy Hend A. , Abodonya Ahmed M. , Abdelbasset Walid Kamal , El-Sakhawy6 Mohamed A.
Published: September 2021

Labor pain (LP) is unbearable and a major source of anxiety and stress. Painful uterine contractions cause hyperventilation in the mother, and because of augmented catecholamine concentration, both the mother and her fetus will be hypoxic. Effective analgesia provides protection from difficulties and ensures good results in both the mother and fetus. Hence, the control of pain should form an integral part of labor management at any level. This brief review aims to identify LP and its effects on fetus and mother, stages of delivery and labor process, and components of LP.
Diagnosis of Intra-Abdominal Pressure in a Patient with Concomitant Injury as a Predictor of the Development of Acute Pancreatitis in the Post-traumatic Period: A Case Report
Authors: Charyshkin Alexei L. , Evseev Roman M. , Smolkina Antonina V. , Manokhin A. V.
Published: September 2021

This article presents a clinical case of treatment of a patient with concomitant trauma. The increase in intra-abdominal pressure (IAP), as a predictor of the development of pancreatitis, was controlled by the developed method of radiation diagnostics. A method for assessing an increase in IAP, as a predictor of acute pancreatitis, is to quantify the volumetric blood flow in the superior mesenteric artery (SMA) and superior mesenteric vein (SMV) by Doppler ultrasound.
Magnetic Resonance Imaging in Diagnosis of Complications of Renal and Ureteral Injuries in Different Periods of Traumatic Disease
Authors: Magomedova Zavazhat M. , Egorova Elena A. , Lezhnev Dmitry A. , Smislenova Margarita V.
Published: September 2021

The aim of this study was to evaluate the effectiveness of MRI in diagnosing combined renal and ureteral injuries at different periods of traumatic disease (TD). Methods and Results: We analyzed the results of diagnostics and treatment of 139 patients (80 women and 59 men) with renal and ureteral injuries aged between 18 and 72 years. There were 67(48.2%) patients in the period of acute reaction to trauma, 40(28.8%) patients with early manifestations, and 32(23%) patients in the period of late manifestations. In 127(91.4%) patients, an urgent plain abdominal X-ray was performed without any preliminary preparation. USI of the abdominal and retroperitoneal space was performed in 108(77.7%) patients in the stage of the primary assessment of renal injury as it was a rapid non-invasive investigation. A whole-body MSCT was performed in 131(94.2%) patients, using the nonionic contrast agents Ultravist (350mg I/ml) and Omnipaque (350mg I/ml). MRI was performed in 125(89.9%) patients, including cases of pregnancy and a medical history of allergies. Contrast-enhanced MSCT had a high diagnostic efficiency in assessing complications in kidney and ureteral injuries at different periods of TD (accuracy of 89.2% for acute reaction, 88.8% for early manifestations, and 89.5% for late manifestations). MRI of the kidneys and ureters was indicated in periods of early and late manifestations of TB to detect renal complications in cases with a discrepancy between clinical manifestations and the results obtained by ultrasound and MSCT (accuracy of 87.5% for early manifestations and 89.9% for late manifestations).
The Genotype Distribution of Human Papillomavirus among HIV-Infected Women Planning Pregnancy in Irkutsk, Russia
Authors: Belyaeva Elena , Genich Eleva , Leshchenko Olga
Published: September 2021

The purpose of our research was to determine the detection frequency of 12 high-risk types of human papillomavirus (HPV) in women with human immunodeficiency virus (HIV) who are planning pregnancy and to assess the results of colposcopy and the state of the cervix in these women, depending on the presence of HPV. Methods and Results: We examined 31 women with HIV infection who sought pregnancy-planning advice at Scientific Center for Family Health and Human Reproduction Problems in Irkutsk during 2014-2015. All HIV-infected women were tested for the presence of high-risk HPV DNA in the epithelium of the cervical canal by PCR. Material for cytological examination (PAP test) was collected during gynecological examination. PAP tests were assessed according to the Bethesda system. All changes were divided into two types: ASCUS and SIL, the last was in its turn divided into two categories: LSIL and HSIL. The frequency of HPV detection in HIV-infected women planning pregnancy was 71%. HPV 16 was found in 16(51.6%) HIV-infected women and ranked first in frequency among 12 types of HPV. HPV 33 and HPV 35 were found in 15(48.4%) and 12(38.7%) HIV-infected women, respectively, and ranked the second and third in frequency among 12 HPV types. We compared abnormal colposcopy results in two groups of patients with HIV infection: Group 1 (n=22) included women with HPV and Group 2 (n=9) included women without HPV. ASCUS was detected in all patients of Group 1 (100%) and in 6(66.7%) women of Group 2. Two women (9.1%) from Group 1 were diagnosed with LSIL and 10(45.5%) women with HSIL. Conclusion: HIV-infected women planning pregnancy and living in Irkutsk form a group at high-risk of HPV infection.
The Assessment of Risk Factors for Development of Disability in Children with Congenital Hypothyroidism in Uzbekistan within a Neonatal Screening
Authors: Rakhimova Gulnara N. , Zhiemuratova Gulshad M. , Aliyevа Anna V.
Published: September 2021

The aim of this study was to detect the most significant risk factors leading to disability in children with congenital hypothyroidism (CH) in the autonomous Republic of Karakalpakstan (RK) during neonatal screening (NS). Methods and Results: We used data of patients with CH registered within NS in the RK in 1998-2019 by the Center for Screening of Mother and Child. To predict and calculate the most significant risk factors for disability in children with CH, we used the method of normalizing intensive indicators by E. Shigan, based on the Bayes theorem. The study recruited 111 patients with CH aged from 2 months to 20 years. Among the patients, there were 79(71.2%) girls and 32(28.8%) boys. Additionally, 34(30.6%) children with CH had been disabled since childhood. The lack of compensation after the start of treatment had the highest and most significant degree of disability risk (RR=6.39, 95% CI: 7.4-1.2). Among patients diagnosed outside of screening, disability developed 4.1 times more often than with the results of NS (RR=4.0, 95% CI: 1.1-10.6). In CH patients diagnosed outside of screening, “absence of reagents” was a significant factor increasing the risk of disability by 6.1 times (RR=6.1, 95% CI: 1.8-11.2). Such risk factors as “home delivery” and “parental refusal of the primary test” increased the risk of disability by 3.4 times (RR=3.4, 95% CI: 2.5-8.4) and 1.6 times (RR=2.4, 95% CI: 2.93-7.12), respectively. The possible errors or false-negative answers in the “normal” secondary test and the “normal” primary test increased the risk of disability by 3.3 times (RR=4.0, 95% CI: 3.2-10.7) and 2.4 times (RR=2.42, 95% CI: 2.93-7.12), respectively. Factors such as the “late response to retesting” (RR=0.82 95% CI: 0.65-0.54), “late awareness on the part of the medical staff” (RR=0.29, 95% CI: 0.27- 0.08), and "parental refusal of treatment" (RR=1.03, 95% CI: 0.81-0.84) showed less significance in patients' disability. The “starting treatment after 1 month” factor was 4.2 times more likely to result in disability than “starting treatment before 1 month” (RR=4.2, 95% CI: 4.5 -1.1). Cancellation of levothyroxine by parents for children up to 3 years of age and cancellation of treatment by parents after 3 years more likely resulted in disability by 1.4 times (RR=1.43, 95% CI: 1.4 -2.01) and 3.3 times (RR=3.33, 95% CI: 3.3-10.9), respectively. Conclusion: the most significant risk factors for the development of disability in children with CH in the RK were (in descending order): no compensation after starting treatment, no reagents for screening, starting treatment after 1 year, diagnostics outside of screening, cancellation of L-T4 by parents before and after age 3 years, false-negative secondary TSH test, false-negative primary test, parents refusing the primary test, and childbirth at home.
The Effectiveness of Local Conservative Therapy after Panretinal Laser Coagulation against the Background of Diabetic Neuropathy
Authors: Ponomareva Maria N. , Petrov Ivan M. , Gribanova Evgeniya K.
Published: September 2021

Background: Panretinal photocoagulation (PRP) (also called scatter laser treatment) remains one of the effective methods of treatment, and it can help to prevent blindness and low vision in diabetic retinopathy (DR). The aim of this study was to investigate the efficacy of local prolonged conservative therapy after PRP and the effect of somatic polymorbidity on visual functions in patients with diabetic neuropathy (DN) at the stage of clinical manifestations based on monitoring the clinical, functional and morphometric parameters of the macular region of the retina. Methods and Results: The study included 78 patients with type 2 diabetes (T2D) who underwent PRP for DR using a VISULAS® 532s solid-state laser (ZEISS). The patients were divided into two groups depending on the presence or absence of DN. Group 1 (n=60, 120 eyes) included patients with DN (stage of clinical manifestations), Group 2 (n=18, 36 eyes) included patients without DN. All patients underwent standard ophthalmological examination: visometry, tonometry, perimetry, biomicroscopy of the anterior segment of the eye and vitreous body, and fundus ophthalmoscopy. Thickness map of the retina was obtained using the RTVue-100 OCT (Optovue, Fremont, CA) EMM5 scan protocol and the Stratus OCT (Carl Zeiss Meditec, USA) radial scan protocol. After laser treatment, all patients, regardless of the treatment stage, were prescribed topically Broxinac® ( Bromfenac ophthalmic solution 0.09%), 1 drop twice a day for a month. In the presence of macular edema, a carbonic anhydrase inhibitor (Dorzolamide 2% solution) was added to the Broxinac® solution (1 drop twice a day) for up to 1 month after each PRP stage. The dynamics of CVA parameters and the retinal thickness of the macular region were assessed before PRP and 3 months after the complex treatment. Based on the monitoring of the clinical, functional and morphometric parameters of the macular region of the retina after PRP in T2D patients, we found a local, prolonged, 3-month conservative therapy to be effective, using the instillation of Broxinac® supplemented with Dorzolamide 2% solution in the presence of macular edema. Conversely, there is a negative effect of somatic polymorbidity (stage 3 chronic kidney disease), aspartate aminotransferase >40U/L) on corrected visual acuity (CVA) and morphometric parameters of the macular region of the retina during PRP in T2D patients with DN at the stage of clinical manifestations.
Spatial Distribution of the N2 and P300 Components of the Auditory Evoked Potential in Women with Arterial Hypertension: A study in the Russian Arctic
Authors: Krivonogova Olga V. , Krivonogova Elena V. , Poskotinova Liliya V.
Published: September 2021

The aim of this study was to evaluate the spatial distribution of the latencies and amplitudes of the N2 and P3 (or P300) components of the AEP in the Russian Arctic working-age women with different levels of BP. Methods and Results: A total of 25 working-age women living in Nadym city for more than 20 years took part in this study. Group 1 (n=12, control group) consisted of women with BP within the normal range (<130/90 mmHg); Group 2 (n=13) consisted of women with AH (AH duration from 1 to 10 years). The parameters of the N2 and P300) components of the AEP were evaluated using an electroencephalograph (Neuron-Spectrum-4/VPM, Russia). An auditory oddball paradigm was used to elicit the oddball ERPs. In Group 2, compared with Group 1, the N2 latency was more pronounced in the parietal (P4, P3), central (C4, C3), frontal (F4, F3), and left temporal (T3, F7) regions. The N2 amplitude in all studied brain regions in individuals of both groups was comparable. The P300 latency did not differ between the two groups. In Group 2, the P300 amplitude was significantly lower in the parietal region (P3) on the left, and in the central and temporal regions on the right (C4, T4). In Group 2, inverse correlations between DBP and the P3 amplitude were revealed in the central (C4: r=-0.88, P=0.001; C3: r=-0.86, P=0.001), frontal (F4: r=-0.76; P=0.01; F3: r=-0.93, P=0.001), and anterior-temporal cerebral regions (F8: r=-0.65, P=0.04; F7: r=-0.64, P=0.04). SBP correlated with the P3 amplitude in the right mid-temporal region (T4: r=0.64, P=0.04). Conclusion: The features of the spatial distribution of the N2 and P3 components of the AEP can be used for early diagnosis of the risk of developing cognitive disorders in AH patients.
A Study of the Influence of New Generation Granulated Sorbents on the Processes Regulating the Aggregate State of the Blood with the Use of Piezoelectric Thromboelastography
Authors: Barannikov Sergey V. , Cherednikov Evgeniy F. , Yuzefovich Igor S. , Mehantjeva Ludmila E. , Filev Igor F. , Maleev Yuri V. , Ovsyannikov Evgeniy S. , Maslova Violetta A.
Published: September 2021

Background: Gastroduodenal bleeding (GDB) and the improvement of endoscopic hemostasis (EH) remain a priority in emergency surgery. This article presents the results of an experimental study of the effects of granular sorbents (Aseptisorb, Aseptisorb-A, Aseptisorb-D) on the system regulating the aggregate state of the blood using modern capabilities of piezoelectric thromboelastography (TEG). Methods and Results: The study involved 12 healthy volunteers (9/75% men and 3/25% women) aged between 18 and 58 years, with the average age of 34.0(26.0;44.0) years. For the study, the blood of healthy volunteers with normal indicators of the system regulating the aggregate state of the blood was used. In vitro experiments: Several tests were performed with the blood of each volunteer. In the first experiment (the control stage), the blood cuvette did not contain the test material. At the second stage of the experiment, the hemostatic properties of new generation granulated sorbents (Aseptisorb, Aseptisorb-A, and Aseptisorb-D) were studied. Experimental studies have shown that the use of granular sorbents Aseptisorb, Aseptisorb-A, and Aseptisorb-D in varying degrees affects the links of platelet and coagulation hemostasis, providing acceleration of thrombosis processes while increasing the maximum density of the clot. These effects determine the effectiveness of the clinical use of these sorbents to stop various types of bleeding. Conclusion: Experimental studies of the effect of granular sorbents on the system regulating the aggregate state of the blood using piezoelectric TEG have shown that the use of Aseptisorb, Aseptisorb-A, and Aseptisorb-D can significantly reduce the time of blood clotting and increase the maximum clot density, which determines the possibility of the use of these sorbents in endoscopic hemostatic treatment for GDB.
Comparative Assessment of Inflammatory Reaction in Experimental Animals after Pleurodesis with Solutions of Hydrogen Peroxide and Talc
Authors: Izyumov Mikhail S. , Bulynin Viktor V. , Ovsyannikov Evgeniy S. , Bobrovskikh Andrey M. , Medvedeva Anastasia V. , Deryaeva Olga G.
Published: September 2021

The aim of our research was to compare the nature and severity of the inflammatory process in the lungs, in the leaves of the visceral and parietal pleura, and in the adjacent subpleural tissues of the chest wall in experimental animals after pleurodesis with solutions of 3% and 6% hydrogen peroxide, and talc. Methods and Results: The experiment was carried out on 200 Wistar rats, weighing 160-180 grams, 10 specimens in a subgroup, depending on the time of the experiment, i.e. 50 specimens in each study group, including the control group. The main criterion by which we determined the comparative characteristics of the effectiveness of talc and 3% and 6% solutions of hydrogen peroxide as preparations used for chemical pleurodesis in the rats was a morphological characteristic of inflammation. This criterion was confirmed by counting free cell populations in lung tissue (lymphocytes, macrophages, neutrophils, histiocytes). All comparison groups were characterized by a gradual increase in the number of lymphocytes, macrophages and histiocytes, ranging from minimum to maximum values, and by a gradual decrease in the number of neutrophils, starting with max and ending with minimum values. The number of lymphocytes, macrophages and histiocytes were increasing faster. But at the same time, for the most part, their number was lower after pleurodesis with 6% hydrogen peroxide. The minimum number of neutrophils and the fastest possible reduction in all cases was observed in pleurodesis with 6% hydrogen peroxide. Conclusion: Pleurodesis with a 6% solution of hydrogen peroxide as a chemical agent significantly affects the quality of the inflammatory response, reducing its duration and severity in the organs and tissues of the rats’ chests, compared with a solution of 3% hydrogen peroxide and talc.
Direct Pharmacological Correction of Oxidative Stress in Rat Kidneys Does Not Facilitate Diabetic Nephropathy
Authors: Zharikov A. Yu. , Filinova S.O. , Mazko O. N. , Makarova O. G. , Bobrov I. P.
Published: September 2021

The aim of this study was to evaluate the effect of alpha-tocopherol acetate (ATA) on the activity of free-radical oxidation (FRO) in renal tissue and renal function in rats with experimental streptozotocin (STZ)-induced diabetes mellitus (DM). Methods and Results: Experiments were conducted on 22 male Wistar rats aged 60-100 days and weighing 250-300g. The animals were divided into two groups (Group 1 (control) and Group 2 (experimental. To induce DM, the animals were injected intraperitoneally 1ml of STZ solution in the citrate buffer at a dose of 65mg/kg. For more selective modeling of type 2 DM, the rats were previously injected with an intraperitoneal solution of cytoflavin based on a nicotinamide dose of 115mg/kg In Croup 2, ATA was administered in the period from the fifth to eighth weeks, inclusive, intragastrically through a tube at a daily dose of 300mg/kg. Experiments showed that after a 4-week course of ATA, the concentration of thiobarbiturate-reactive products in the kidney tissues of the rats in Group 2 was 5.3 times lower than in Group 1. The activity of all antioxidant enzymes did not differ between the two groups. In both groups, during all 8 weeks of the experiment, the levels of renal excretion of glucose, protein, and creatinine significantly exceeded the initial level, while the level of diuresis remained stable. Conclusion: The long-term administration of ATA in experimental streptozotocin (STZ)-induced DM is accompanied by a significant suppression of the activity of the FRO processes in the kidneys, but does not lead to an improvement in the course of DN.
Biomedicine in the COVID Age: Opportunities, Responses, and Challenges
Authors: Rao Gundu H. R.
Published: September 2021

According to one of the earliest definitions, biomedicine means “clinical medicine based on the principles of physiology and biochemistry.” Clinicians for quite some time preferred the use of the term medical research to describe what they considered the clinical findings pertaining to various issues related to clinical studies. Since the time when the basic molecules of life, deoxyribonucleic acids, were characterized and the genetic code elucidated, there has been great excitement, anticipation, and promise for the development of precision and personalized medicine. However, the progress has been considerably slow and at times disappointing. The unprecedented coronavirus disease created a worldwide panic and exposed all our weaknesses and unpreparedness. It also demonstrated a global demand for better public health infrastructure and preparedness to combat future pandemics. This unprecedented public health crisis acted as a great stimulus for putting together a concerted effort to develop vaccines. According to the experts, the time was right and within 48 hours after the information on the SARS-CoV-2 genome was posted, Moderna scientists had on paper a workable mRNA, which would code for the spike protein. The immune engineers at Moderna as well as BioNTech were able to put together a lipid nanoparticle delivery system for safe delivery of this precious cargo to the appropriate cells. Professor Cody Meissner at Tufts University School of Medicine in Boston says, “It is absolutely astonishing that this happened [COVID Vaccine development] in such a short time—to me, it is equivalent to putting a person on the Moon.” It is indeed a great achievement, and it demonstrated the power of basic science and emerging technologies. The extraordinary success of mRNA vaccines has opened new avenues for mRNA-based therapies. mRNAs, siRNAs, and non-coding miRNAs will play a very important role as novel therapeutics soon. Furthermore, this success has acted as a catalyst for ongoing work on the use of small RNAs for therapeutic purposes. Having said that, I must say that there are a great many challenges that need to be addressed.
Milestones in Molecular Mechanisms of Adipogenesis and Adipose Tissue Plasticity
Authors: Shatova Olga P. , Zabolotneva Anastasia A. , Potievskiy Mikhail B. , Shestopalov Aleksandr V. , Roumiantsev Sergei A.
Published: September 2021

This review focuses on the problem of adipogenesis mechanisms and the biological role of adipose tissue (AT) in the human body. Over the past decades, various types of adipocytes have been identified and characterized—white, brown, beige, yellow, and pink. An important feature of AT is a high plasticity and the ability to transdifferentiate and de-differentiate into another cell type. In this case, the pathway of transformation mostly depends on adipocytes’ cellular and metabolic microenvironment. The mechanisms of adipogenesis and the ways of its regulation remain not fully understood. The principal role in the terminal differentiation of preadipocytes is assigned to PPARγ and receptors activated by bone morphogenetic proteins, insulin, and cortisol. However, in chronic inflammation, adipogenesis is suppressed and old adipocytes increase the production of proinflammatory cytokines, which leads to the death of inflamed cells and hypertrophy of neighboring adipocytes. Thus, disruption of adipogenesis, premature aging of white adipocytes, perturbations in the metabolic and cellular microenvironment of preadipocytes, and early apoptosis of fat cells cause the development of insulin resistance and metabolically unhealthy obesity.
Polos fríos en el Calar de Hernán Pelea y Cabrilla (Jaén, España), factores sinópticos y de microescala
Authors: Espín Sánchez David , Conesa García Carmelo , Olcina Cantos Jorge
Published: September 2021

Los extensos e inhóspitos calares ubicados en las Sierra de Segura y Cabrilla (divisoria entre las demarcaciones hidrográficas del Segura y Guadalquivir) presentan un estereotipo microclimático caracterizado por inviernos extremadamente fríos, con temperaturas mínimas absolutas cercanas a -30ºC en invierno, y -10ºC y -15ºC en otoño y primavera respectivamente. Los datos registrados han sido obtenidos de una red propia de termómetros registradores (datalogger) entre octubre de 2016 y febrero de 2021 (con un total de cinco inviernos de observación). A través del análisis estadístico de datos diezminutales y diarios de tres puntos de observación (Monterilla, Navalasno y Nava del Polvo), imágenes satelitales (VIIRS LST) y reanálisis mesoescalares es posible llevar a cabo la primera descripción climática del área de estudio, así como la identificación de los factores desencadenantes (sinópticos y de microescala) de las temperaturas mínimas extremas registradas, y el análisis de la tipología de los procesos de inversión térmica nocturna (ITN) y las piscinas de aire frío (CAP) generadas en el área de estudio. A pesar de que el tipo de piscina fría predominante es la de erosión turbulenta (39,0 %), los procesos de estabilidad nocturno son intensos (CINV entre 7,6 y 12,5ºC).
Incorporation of Neutrally Buoyant Proppants in Horizontal Unconventional Wells to Increase Propped Fracture Area Results for Substantially Improved Well Productivity and Economics
Authors: Brannon Harold , Hoffman Nicole
Published: September 2021

Hydraulic fracturing stimulation of unconventional wells employing large volumes of sand in low viscosity fluids provides propped fracture conductivity in less than 25% of the created fracture area, primarily because of poor sand transport mechanics. The remaining unpropped area is at best only marginally productive using the conventional sand/slickwater hydraulic fracturing process alone. Near-neutrally buoyant proppants (NBPs, ASG 1.055) have proven to be highly effective in accessing production from fracture area that is otherwise left unpropped. Fracture models illustrate the propped fracture area of designs incorporating NBPs is improved to over 85% of the created fracture area. Production simulations of typical slickwater and sand frac designs supplemented with NBPs at 3% by weight of sand distributed evenly throughout the slurry stages show cumulative production increases of 20% to greater than 50% compared to the large volume slickwater/sand treatments without NBPs.

Efforts have been directed to justification of the incremental expense involved with the NBP applications and assessment of the associated value-added economic metrics, including the value of the realized incremental production vs. time, the payback time for recovery of the incremental costs, and Return on Investment (ROI). For example, in a 2018 trial of NBP wells in the Middle Bakken formation of North Dakota, the production uplift observed for NBP wells achieved payback of the incremental costs in an average of 26 days; the 1-year cumulative oil production of the NBP wells averaged 69,632 barrels greater than control wells, resulting in a 25% uplift compared to the offset control wells. The Year 1 Return on Investment (ROI) for the drilling and completion costs of the first Middle Bakken well with NBP was 97% versus 64% for the sand-only control wells.

Controlled multi-stage horizontal completions of wells with sand-only have been evaluated against wells utilizing NBPs in the application have been executed within several unconventional plays, including the Permian and Williston basins. The performance of the NBP wells have consistently validated the production uplift predictions of the production simulation models. The case studies analyzed herein expand the economic assessment of the NBP stimulation designs by including production analyses quantitative comparison of Net Present Value, production decline rates, and projected EURs of the NBP wells and non-NBP offset wells.
An Integrated Ensemble-Based Uncertainty Centric Approach to Address Multi-Disciplinary Reservoir Challenges While Accelerating Subsurface Modeling Process in an Onshore Field, Abu Dhabi, UAE
Authors: Alqallabi Salahaldeen , Khan Abdul Saboor , Phade Anish , Gacem Mohamed Tarik , Adli Mustapha , Al-Jenaibi Faisal , Mansur Sheharyar , Malla Lyes , Benedictis Dario
Published: September 2021

The aim of this study is to demonstrate the value of a fully integrated ensemble-based modeling approach for an onshore field in Abu Dhabi. Model uncertainties are included in both static and dynamic domains and valuable insights are achieved in record time of nine-weeks with very promising results.

Workflows are established to honor the recommended static and dynamic modeling processes suited to the complexity of the field. Realistic sedimentological, structural and dynamic reservoir parameter uncertainties are identified and propagated to obtain realistic variability in the reservoir simulator response. These integrated workflows are used to generate an ensemble of equi-probable reservoir models. All realizations in the ensemble are then history-matched simultaneously before carrying out the production predictions using the entire ensemble.

Analysis of the updates made during the history-matching process demonstrates valuable insights to the reservoir such as the presence of enhanced permeability streaks. These represent a challenge in the explicit modeling process due to the complex responses on the well log profiles. However, results analysis of the history matched ensemble shows that the location of high permeability updates generated by the history matching process is consistent with geological observations of enhanced permeability streaks in cores and the sequence stratigraphic framework. Additionally, post processing of available PLT data as a blind test show trends of fluid flow along horizontal wells are well captured, increasing confidence in the geologic consistency of the ensemble of models. This modeling approach provides an ensemble of history- matched reservoir models having an excellent match for both field and individual wells’ observed field production data. Furthermore, with the recommended modeling workflows, the generated models are geologically consistent and honor inherent correlations in the input data. Forecast of this ensemble of models enables realistic uncertainties in dynamic responses to be quantified, providing insights for informed reservoir management decisions and risk mitigation.

Analysis of forecasted ensemble dynamic responses help evaluating performance of existing infill targets and delineate new infill targets while understanding the associated risks under both static and dynamic uncertainty. Repeatable workflows allow incorporation of new data in a robust manner and accelerates time from model building to decision making.