bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting ADRB2 enhances sensitivity of non-small cell lung cancer to VEGFR2 tyrosine kinase inhibitors
Authors: Xu Yingzhuo , Wang Jian , Wang Xu , Zhou Xiaoshu , Tang Jing , Jie Xiaohua , Yang Xijie , Rao Xinrui , Xu Yunhong , Xing Biyuan , Li Zhenyu , Wu Gang
Published: January 2022

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) tyrosine kinase inhibitors (TKIs) have achieved remarkable clinical progress in the treatment of non-small-cell lung cancer; however, resistance has limited their therapeutic efficacy. Therefore, understanding the mechanisms of VEGF-TKI and ICI resistance will help to develop effective treatment strategies for patients with advanced NSCLC. Our results suggested that treatment with VEGFR2-TKIs upregulated ADRB2 expression in NSCLC cells. Propranolol, a common ADRB2 antagonist, significantly enhanced the therapeutic effect of VEGFR2-TKIs by inhibiting the ADRB2 signaling pathway in NSCLC cells in vitro and in vivo. Mechanically, the treatment-induced ADRB2 upregulation and the enhancement of ADRB2/VEGFR2 interaction caused resistance to VEGFR2-TKIs in NSCLC. And the inhibition of the ADRB2/CREB/PSAT1 signaling pathway sensitized cells to VEGFR2-TKIs. We demonstrated that ADRB2 signaling is crucial in mediating resistance to VEGFR2-TKIs and provided a novel promising combinatory approach to enhance the antitumor effect of VEGFR2-TKIs in NSCLC combining with propranolol.
ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells
Authors: Hagenlocher Cathrin , Siebert Robin , Taschke Bruno , Wieske Senait , Hausser Angelika , Rehm Markus
Published: January 2022

Prolonged ER stress and the associated unfolded protein response (UPR) can trigger programmed cell death. Studies in cancer cell lines demonstrated that the intracellular accumulation of TRAIL receptor-2 (TRAIL-R2) and the subsequent activation of caspase-8 contribute significantly to apoptosis induction upon ER stress. While this might motivate therapeutic strategies that promote cancer cell death through ER stress-induced caspase-8 activation, it could also support the unwanted demise of non-cancer cells. Here, we therefore investigated if TRAIL-R2 dependent signaling towards apoptosis can be induced in pancreatic β cells, whose loss by prolonged ER stress is associated with the onset of diabetes. Interestingly, we found that elevated ER stress in these cells does not result in TRAIL-R2 transcriptional induction or elevated protein levels, and that the barely detectable expression of TRAIL-R2 is insufficient to allow TRAIL-induced apoptosis to proceed. Overall, this indicates that apoptotic cell death upon ER stress most likely proceeds independent of TRAIL-R2 in pancreatic β cells. Our findings therefore point to differences in ER stress response and death decision-making between cancer cells and pancreatic β cells and also have implications for future targeted treatment strategies that need to differentiate between ER stress susceptibility of cancer cells and pancreatic β cells.
Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development
Authors: Magaletta Margaret E. , Lobo Macrina , Kernfeld Eric M. , Aliee Hananeh , Huey Jack D. , Parsons Teagan J. , Theis Fabian J. , Maehr René
Published: January 2022

Maldevelopment of the pharyngeal endoderm, an embryonic tissue critical for patterning of the pharyngeal region and ensuing organogenesis, ultimately contributes to several classes of human developmental syndromes and disorders. Such syndromes are characterized by a spectrum of phenotypes that currently cannot be fully explained by known mutations or genetic variants due to gaps in characterization of critical drivers of normal and dysfunctional development. Despite the disease-relevance of pharyngeal endoderm, we still lack a comprehensive and integrative view of the molecular basis and gene regulatory networks driving pharyngeal endoderm development. To close this gap, we apply transcriptomic and chromatin accessibility single-cell sequencing technologies to generate a multi-omic developmental resource spanning pharyngeal endoderm patterning to the emergence of organ-specific epithelia in the developing mouse embryo. We identify cell-type specific gene regulation, distill GRN models that define developing organ domains, and characterize the role of an immunodeficiency-associated forkhead box transcription factor.
Significance of gene variants for the functional biogeography of the near-surface Atlantic Ocean microbiome
Authors: Dlugosch Leon , Poehlein Anja , Wemheuer Bernd , Pfeiffer Birgit , Badewien Thomas H. , Daniel Rolf , Simon Meinhard
Published: January 2022

Microbial communities are major drivers of global elemental cycles in the oceans due to their high abundance and enormous taxonomic and functional diversity. Recent studies assessed microbial taxonomic and functional biogeography in global oceans but microbial functional biogeography remains poorly studied. Here we show that in the near-surface Atlantic and Southern Ocean between 62°S and 47°N microbial communities exhibit distinct taxonomic and functional adaptations to regional environmental conditions. Richness and diversity showed maxima around 40° latitude and intermediate temperatures, especially in functional genes (KEGG-orthologues, KOs) and gene profiles. A cluster analysis yielded three clusters of KOs but five clusters of genes differing in the abundance of genes involved in nutrient and energy acquisition. Gene profiles showed much higher distance-decay rates than KO and taxonomic profiles. Biotic factors were identified as highly influential in explaining the observed patterns in the functional profiles, whereas temperature and biogeographic province mainly explained the observed taxonomic patterns. Our results thus indicate fine-tuned genetic adaptions of microbial communities to regional biotic and environmental conditions in the Atlantic and Southern Ocean.
Cocoa bean fingerprinting via correlation networks
Authors: Kumar Santhust , D’Souza Roy N. , Corno Marcello , Ullrich Matthias S. , Kuhnert Nikolai , Hütt Marc-Thorsten
Published: January 2022

Cocoa products have a remarkable chemical and sensory complexity. However, in contrast to other fermentation processes in the food industry, cocoa bean fermentation is left essentially uncontrolled and is devoid of standardization. Questions of food authenticity and food quality are hence particularly challenging for cocoa. Here we provide an illustration how network science can support food fingerprinting and food authenticity research. Using a large dataset of 140 cocoa samples comprising three cocoa fermentation/processing stages and eight countries, we obtain correlation networks between the cocoa samples by computing measures of pairwise correlation from their liquid chromatography-mass spectrometry (LC-MS) profiles. We find that the topology of correlation networks derived from untargeted LC-MS profiles is indicative of the fermentation and processing stage as well as the origin country of cocoa samples. Progressively increasing the correlation threshold firstly reveals network clusters based on processing stage and later country-based clusters. We present both, qualitative and quantitative evidence through network visualization, network statistics and concepts from machine learning. In our view, this network-based approach for classifying mass spectrometry data has broad applicability beyond cocoa.
Muscle-derived fibro-adipogenic progenitor cells for production of cultured bovine adipose tissue
Authors: Dohmen Richard G. J. , Hubalek Sophie , Melke Johanna , Messmer Tobias , Cantoni Federica , Mei Arianna , Hueber Rui , Mitic Rada , Remmers Dirk , Moutsatsou Panagiota , Post Mark J. , Jackisch Laura , Flack Joshua E.
Published: January 2022

Cultured meat is an emergent technology with the potential for significant environmental and animal welfare benefits. Accurate mimicry of traditional meat requires fat tissue; a key contributor to both the flavour and texture of meat. Here, we show that fibro-adipogenic progenitor cells (FAPs) are present in bovine muscle, and are transcriptionally and immunophenotypically distinct from satellite cells. These two cell types can be purified from a single muscle sample using a simple fluorescence-activated cell sorting (FACS) strategy. FAPs demonstrate high levels of adipogenic potential, as measured by gene expression changes and lipid accumulation, and can be proliferated for a large number of population doublings, demonstrating their suitability for a scalable cultured meat production process. Crucially, FAPs reach a mature level of adipogenic differentiation in three-dimensional, edible hydrogels. The resultant tissue accurately mimics traditional beef fat in terms of lipid profile and taste, and FAPs thus represent a promising candidate cell type for the production of cultured fat.
Peeking into a black box, the fairness and generalizability of a MIMIC-III benchmarking model
Authors: Röösli Eliane , Bozkurt Selen , Hernandez-Boussard Tina
Published: January 2022

As artificial intelligence (AI) makes continuous progress to improve quality of care for some patients by leveraging ever increasing amounts of digital health data, others are left behind. Empirical evaluation studies are required to keep biased AI models from reinforcing systemic health disparities faced by minority populations through dangerous feedback loops. The aim of this study is to raise broad awareness of the pervasive challenges around bias and fairness in risk prediction models. We performed a case study on a MIMIC-trained benchmarking model using a broadly applicable fairness and generalizability assessment framework. While open-science benchmarks are crucial to overcome many study limitations today, this case study revealed a strong class imbalance problem as well as fairness concerns for Black and publicly insured ICU patients. Therefore, we advocate for the widespread use of comprehensive fairness and performance assessment frameworks to effectively monitor and validate benchmark pipelines built on open data resources.
Transcription shifts in gut bacteria shared between mothers and their infants
Authors: Vatanen Tommi , Sakwinska O. , Wilson B. , Combremont S. , Cutfield W. S. , Chan S. Y. , Godfrey K. M. ,   NiPPeR Study Group, Sakwinska O. , Cutfield W. S. , Chan S. Y. , Godfrey K. M. , O’Sullivan J. M. , Barton Sheila J. , Cavanagh Mary , Chong Yap Seng , Costello Paula , Cox Vanessa , El-Heis Sarah , Jagtap Mrunalini , Lillycrop Karen , Nield Heidi , Satianegara Gernalia , Silva-Zolezzi Irma , Soh Shu E. , Woon Gladys , Kenealy Tim , Vickers Mark , Swann Jonathan , O’Sullivan Justin M.
Published: January 2022

The infant gut microbiome contains a portion of bacteria that originate from the maternal gut. In the infant gut these bacteria encounter a new metabolic environment that differs from the adult gut, consequently requiring adjustments in their activities. We used pilot community RNA sequencing data (metatranscriptomes) from ten mother-infant dyads participating in the NiPPeR Study to characterize bacterial gene expression shifts following mother-to-infant transmission. Maternally-derived bacterial strains exhibited large scale gene expression shifts following the transmission to the infant gut, with 12,564 activated and 14,844 deactivated gene families. The implicated genes were most numerous and the magnitude shifts greatest in Bacteroides spp. This pilot study demonstrates environment-dependent, strain-specific shifts in gut bacteria function and underscores the importance of metatranscriptomic analysis in microbiome studies.
Thermodynamic mechanism of the density and compressibility anomalies of water in the range − 30 < T (°C) < 100
Authors: Yasutomi Makoto
Published: January 2022

Compared to normal liquids, water exhibits a variety of anomalous thermal behaviors. This fact has been known for centuries. However, the thermodynamic mechanisms behind them have not been elucidated despite the efforts of many researchers. Under such circumstances, the author theoretically reproduced the measured values of the density-temperature curve at 1 atm for water above 0 $$^\circ $$

∘

C. Then, the mystery of negative thermal expansion was clarified in relation to the shapes of the intermolecular interactions. In this paper, the author develops this line of work further and presents the interactions between water molecules to simultaneously reproduce the measured values of both the density-temperature curve and the isothermal compressibility-temperature curve in the range $$-30<T(^\circ {\mathrm{C}})<100$$

-
30
<
T

(
∘

C
)
<
100

at 1 atm. Then, the thermodynamic mechanism that produces these thermal behaviors is clarified in relation to the shapes of the interactions between molecules. Unraveling the mystery of related phenomena in relation to the shapes of the interaction between molecules has been a traditional and fundamental method in physics since the days of Newton.
Evaluation of alveolar bone hypomineralization in pediatric hypophosphatasia using orthopantomography
Authors: Okawa Rena , Nakamoto Takashi , Matayoshi Saaya , Nakano Kazuhiko , Kakimoto Naoya
Published: January 2022

Hypophosphatasia (HPP) is a metabolic disease characterized by impaired bone mineralization and early exfoliation of primary teeth. This study was performed to develop a method for quantitatively evaluating alveolar bone hypomineralization using orthopantomographic images. Alveolar bone density was defined according to the pixel values and corrected by brightness shown by an indicator applied to the orthopantomographic device. Images of 200 healthy subjects (aged 2–15 years) were classified into five age groups. The corrected pixel values were significantly lower in the younger group than in those aged 14–15 years (2–4, 5–7, and 8–10 years versus 14–15 years: P < 0.0001, 11–13 years versus 14–15 years: P < 0.01). Orthopantomographic images of 17 patients with HPP were evaluated. The corrected pixel values of three-fourths of the patients with odonto type HPP were lower than the mean values of the healthy group. One-third of patients treated with enzyme replacement therapy showed higher corrected pixel values than the healthy group. Our results suggest that odonto type HPP without skeletal problems is occasionally accompanied by hypomineralization of alveolar bone and that alveolar bone hypomineralization in patients with severe HPP is possibly improved by enzyme replacement therapy.
Silencing acetyl-CoA carboxylase A and sterol regulatory element-binding protein 1 genes through RNAi reduce serum and egg cholesterol in chicken
Authors: Prasad Athe Rajendra , Bhattacharya T. K. , Chatterjee R. N. , Divya D. , Bhanja S. K. , Shanmugam M. , Sagar N. G.
Published: January 2022

Cholesterol is synthesized in chicken through de novo lipid biosynthetic pathway where two most important genes viz. SREBP1 and ACACA play immense role. To minimize cholesterol synthesis, RNAi approach was adopted and accordingly, we developed transgenic chicken possessing ACACA and SREBP1 shRNA constructs, which showed lower level of ACACA and SREBP1 in serum. The serum total cholesterol, triglycerides, HDL and LDL cholesterol was significantly lower by 23.8, 35.6, 26.6 and 20.9%, respectively in SREBP1 transgenic birds compared to the control. The egg total cholesterol and LDL cholesterol content was numerically lower in both ACACA and SREBP1 transgenic birds by 14.3 and 13.2%, and 10.4 and 13.7%, respectively compared to the control. It is concluded that the protocol was perfected to develop transgenic chicken through RNAi for knocking down the expression of ACACA and SREBP1 proteins, which minimized the cholesterol and triglycerides contents in serum and eggs.
A computational modeling of invadopodia protrusion into an extracellular matrix fiber network
Authors: Kim Min-Cheol , Li Ran , Abeyaratne Rohan , Kamm Roger D. , Asada H. Harry
Published: January 2022

Invadopodia are dynamic actin-rich membrane protrusions that have been implicated in cancer cell invasion and metastasis. In addition, invasiveness of cancer cells is strongly correlated with invadopodia formation, which are observed during extravasation and colonization of metastatic cancer cells at secondary sites. However, quantitative understanding of the interaction of invadopodia with extracellular matrix (ECM) is lacking, and how invadopodia protrusion speed is associated with the frequency of protrusion-retraction cycles remains unknown. Here, we present a computational framework for the characterization of invadopodia protrusions which allows two way interactions between intracellular branched actin network and ECM fibers network. We have applied this approach to predicting the invasiveness of cancer cells by computationally knocking out actin-crosslinking molecules, such as α-actinin, filamin and fascin. The resulting simulations reveal distinct invadopodia dynamics with cycles of protrusion and retraction. Specifically, we found that (1) increasing accumulation of MT1-MMP at tips of invadopodia as the duration of protrusive phase is increased, and (2) the movement of nucleus toward the leading edge of the cell becomes unstable as duration of the retractile phase (or myosin turnover time) is longer than 1 min.
Neuronal population activity dynamics reveal a low-dimensional signature of operant learning in Aplysia
Authors: Costa Renan M. , Baxter Douglas A. , Byrne John H.
Published: January 2022

Learning engages a high-dimensional neuronal population space spanning multiple brain regions. However, it remains unknown whether it is possible to identify a low-dimensional signature associated with operant conditioning, a ubiquitous form of learning in which animals learn from the consequences of behavior. Using single-neuron resolution voltage imaging, here we identify two low-dimensional motor modules in the neuronal population underlying Aplysia feeding. Our findings point to a temporal shift in module recruitment as the primary signature of operant learning. Our findings can help guide characterization of learning signatures in systems in which only a smaller fraction of the relevant neuronal population can be monitored.
High-throughput screening, next generation sequencing and machine learning: advanced methods in enzyme engineering
Authors: Vanella Rosario , Kovacevic Gordana , Doffini Vanni , Fernández de Santaella Jaime , Nash Michael A.
Published: January 2022

Enzyme engineering is an important biotechnological process capable of generating tailored biocatalysts for applications in industrial chemical conversion and biopharma.
Degradation of amyloid peptide aggregates by targeted singlet oxygen delivery from a benzothiazole functionalized naphthalene endoperoxide
Authors: Wu Hao , Liu Ziang , Shao Yujie , Li Guangzhe , Pan Yue , Wang Lei , Akkaya Engin U.
Published: January 2022

The endoperoxide form (BZTN-O2) of the naphthalene–benzothiazole conjugate successfully inhibited and/or reversed amyloid aggregation.
A dipodal bimane–ditriazole–diCu(ii) complex serves as an ultrasensitive water sensor
Authors: Karmakar Joy , Pramanik Apurba , Joseph Vincent , Marks Vered , Grynszpan Flavio , Levine Mindy
Published: January 2022

A bimane ditriazole–copper(ii) complex serves as an ultrasensitive water sensor. Key features of the system also include rapid response times and good selectivity for water compared to other protic solvents.
Simultaneously higher thermal stability and lower resistance drifting for Sb/In48.9Sb15.5Te35.6 nanocomposite multilayer films
Authors: Gao Shiwei , Hu Yifeng
Published: January 2022

In this study, In48.9Sb15.5Te35.6 (IST) was introduced as a stable interlayer to improve the weak amorphous thermal stability and large resistance drift of Sb films.
Molecular insight into the role of zeolite lattice constraints on methane activation over the Cu–O–Cu active site
Authors: Mahyuddin Muhammad Haris , Saputro Adhitya Gandaryus , Sukanli Reza Pamungkas Putra , Fathurrahman Fadjar , Rizkiana Jenny , Nuruddin Ahmad , Dipojono Hermawan Kresno
Published: January 2022

The zeolite ring structure constrains the Cu–μO–Cu geometry and determines how the Cu–μO–Cu bonds weaken to allow a μO–H bond to form during the H–CH3 bond cleavage. The weaker the Cu–μO–Cu bonds, the stronger the μO–H bond.
Study on the monolayer dispersion behavior of SnO2 on ZSM-5 for NOx-SCR by C3H6: the remarkable promotional effects of air plasma treatment
Authors: Zhang Lihong , Lai Qiang , Liu Yaqian , Li Xian , Zhang Wenqi , Xu Xianglan , Fang Xiuzhong , Xu Junwei , Wang Xiang
Published: January 2022

Plasma treatment promotes the monolayer dispersion threshold of SnO2 on H-ZSM-5 and the performance of SnO2/ZSM-5 for NOx-SCR by C3H6.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats
Authors: Liu Yaping , Huang Haoyue , Xu Ze , Xue Yuan , Zhang Dongdong , Zhang Yujing , Li Wenjie , Li Xing
Published: January 2022

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats induced by a high fat diet and streptozotocin.
Sustainable C–H functionalization under ball-milling, microwave-irradiation and aqueous media
Authors: Laskar Ranjini , Pal Tanay , Bhattacharya Trisha , Maiti Siddhartha , Akita Munetaka , Maiti Debabrata
Published: January 2022

This tutorial review gathers landmark work on transition-metal mediated C–H activation reactions using more sustainable approaches. We endeavour to promote and propagate such lines of research, reducing the usage of hazardous synthetic routes in chemical synthesis.
Highly porous nitrogen-doped carbon superstructures derived from the intramolecular cyclization-induced crystallization-driven self-assembly of poly(amic acid)
Authors: Sun Hui , Li Xiao , Jin Kai , Lai Xiaoyong , Du Jianzhong
Published: January 2022

Nitrogen-doped carbon superstructures derived from ICI-CDSA exhibited high specific capacitance contributed by considerable pseudocapacitance up to 40.6%, corresponding to a high active nitrogen utilization of 12.9%.
Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs
Authors: Radziwon Agata , Bhangu Sukhvir K. , Fernandes Soraia , Cortez-Jugo Christina , De Rose Robert , Dyett Brendan , Wojnilowicz Marcin , Laznickova Petra , Fric Jan , Forte Giancarlo , Caruso Frank , Cavalieri Francesca
Published: January 2022

Nanocomplexes of glycogen nanoparticles with serum albumin were formed by triggering the nanophase separation of albumin. The nanocomplexes enabled the delivery of chemotherapeutics in complex multicellular 3D tumour-like structures.
Hyperbaric reactions in organic synthesis. Progress from 2006 to 2021
Authors: Rulev Alexander Yu. , Zubkov Fedor I.
Published: January 2022

This account systematizes a hundred papers (2006–2021 yy) in order to highlight the advantages of hyperbaric conditions (1–20 kbar) in preparative organic synthesis.
DABSO as a SO2 gas surrogate in the synthesis of organic structures
Authors: Seyed Hashtroudi Mehri , Fathi Vavsari Vaezeh , Balalaie Saeed
Published: January 2022

Using DABSO as a substrate, different simple to complex structures can be constructed, such as sulfonyl fluorides, sulfonamides, sulfonohydrazides, sulfonic esters, and sulfones. In this review, we investigate the role of DABSO in organic synthesis.
Pyrolytic activation of cellulose: energetics and condensed phase effects
Authors: Padmanathan Arul Mozhi Devan , Mushrif Samir H.
Published: January 2022

Computational strategies used to capture condensed phase effects provide a novel outlook on cellulose chemistry. With phase transition, cellulose primary decomposition has a significant entropic penalty below 900 K but is enthalpy controlled beyond.
Electronic structure studies reveal 4f/5d mixing and its effect on bonding characteristics in Ce-imido and -oxo complexes
Authors: Moreau Liane M. , Lapsheva Ekaterina , Amaro-Estrada Jorge I. , Gau Michael R. , Carroll Patrick J. , Manor Brian C. , Qiao Yusen , Yang Qiaomu , Lukens Wayne W. , Sokaras Dimosthenis , Schelter Eric J. , Maron Laurent , Booth Corwin H.
Published: January 2022

Ce(iv) complexes with multiple bonds display similar f0 fractions, but different f/d hybridization, 5d-orbital energies, and TIP levels.
Electronic properties of graphene oxide: nanoroads towards novel applications
Authors: Khabibrakhmanov Almaz I. , Sorokin Pavel B.
Published: January 2022

In this work, we investigate in detail the atomic structure of graphene oxide and suggest an approach to widely tune its electronic properties.
The eROSITA Final Equatorial-Depth Survey (eFEDS)
Authors: Bahar Y. Emre , Bulbul Esra , Clerc Nicolas , Ghirardini Vittorio , Liu Ang , Nandra Kirpal , Pacaud Florian , Chiu I-Non , Comparat Johan , Ider-Chitham Jacob , Klein Mathias , Liu Teng , Merloni Andrea , Migkas Konstantinos , Okabe Nobuhiro , Ramos-Ceja Miriam E. , Reiprich Thomas H. , Sanders Jeremy S. , Schrabback Tim
Published: January 2022

Context.Scaling relations link the physical properties of clusters at cosmic scales. They are used to probe the evolution of large-scale structure, estimate observables of clusters, and constrain cosmological parameters through cluster counts.

Aims.We investigate the scaling relations between X-ray observables of the clusters detected in the eFEDS field using Spectrum-Roentgen-Gamma/eROSITA observations taking into account the selection effects and the distributions of observables with cosmic time.

Methods.We extract X-ray observables (LX,Lbol,T,Mgas,YX) withinR500for the sample of 542 clusters in the eFEDS field. By applying detection and extent likelihood cuts, we construct a subsample of 265 clusters with a contamination level of <10% (including AGNs and spurious fluctuations) to be used in our scaling relations analysis. The selection function based on the state-of-the-art simulations of the eROSITA sky is fully accounted for in our work.

Results.We provide the X-ray observables in the core-included <R500and core-excised 0.15R500-R500apertures for 542 galaxy clusters and groups detected in the eFEDS field. Additionally, we present our best-fit results for the normalization, slope, redshift evolution, and intrinsic scatter parameters of the X-ray scaling relations betweenLX-T,LX-Mgas,LX-YX,Lbol-T,Lbol-Mgas,Lbol-YX, andMgas-T. We find that the best-fit slopes significantly deviate from the self-similar model at a >4σ confidence level, but our results are nevertheless in good agreement with the simulations including non-gravitational physics, and the recent results that take into account selection effects.

Conclusions.The strong deviations we find from the self-similar scenario indicate that the non-gravitational effects play an important role in shaping the observed physical state of clusters. This work extends the scaling relations to the low-mass, low-luminosity galaxy cluster and group regime using eFEDS observations, demonstrating the ability of eROSITA to measure emission from the intracluster medium out toR500with survey-depth exposures and constrain the scaling relations in a wide mass-luminosity-redshift range.
The effect of concentration of ab mix and zpt solutions on the growth and production of mustard plants (Brassica juncea L.) in hydroponic wick systems
Authors: Reza Subakti Muhammad , Nurhayati  , Sari Rahayu Murni
Published: January 2022

This research was implemented in the greenhouse at the Experimental Garden of the Faculty of Agriculture Universitas Islam Sumatera Utara, Sub-distric Gedung Johor, Medan Johor District, Medan City, North Sumatra Province. This research was implemented from November to December 2020. This study aims to determine the effect of concentration of AB Mix and ZPT solutions on the growth and production of mustard greens. This study used a completely randomized design (CRD) with two treatment factors the concentration of AB Mix solution and ZPT application. The first factors, the concentration of AB Mix solution consisting of 3 levels: K0 = control, K1 = 550 ppm, K2 = 1100 ppm. The second factor was giving ZPT the earliest in 3 levels: Z0 = control, Z1 = 0.5 ml, Z2 = 1 ml. The parameters observed were plant height, number of leaves, leaf length, leaf width, wet weight and dry weight. Its is know from the results concentrations of AB Mix solution significantly affected plant height, number of leaves, leaf length, leaf width, wet weight and dry weight. Giving of ZPT had a significant effect on leaf width but had no significant effect on plant height, number of leaves, leaf length, wet weight and dry weight. The interaction of AB Mix solution concentration and ZPT giving had no significant effect on the growth and production of mustard greens.
Mapping potential fishing zones based on sea surface temperature and Chlorophyll-A in the Waters of Aceh Besar, Indonesia
Authors: Muhammad Muhammad , Widi Priana Agus , Affan Junaidi M. , Azief Haridhi Haekal , Irwan Irwan , Meurah Yuni Syarifah , Setiawan Ichsan
Published: January 2022

Utilization of potential fishery and marine resources is still not maximally used by fishermen. Sea surface temperatures and the spread of chlorophyll-a through remote sensing systems can be used as potential fishing zones. This study aims to determine potential fishing zones using geographic information systems through the distribution of sea surface temperatures and the value of chlorophyll-a concentrations in Aceh Besar waters which is expected to improve the sustainability of fishing efforts. This research was conducted in January-December 2019 using geographic information system by extracting from Aqua-MODIS satellite image with resolution of 4 km and sea surface temperature overlay method with chlorophyll-a concentration. The results found the highest sea surface temperature value was in April at 31.62°C and the lowest temperature was in December at 28.45°C. The highest average chlorophyll-a concentration in Aceh Besar waters was 1.53 mg/m3 in December and the lowest concentration of chlorophyll-a in June and September was 0.20 mg/m3. Suspected potential fishing zones during January to December 2019 were found as many as 62 potential fishing zones, namely in the Western, Northwest and Eastern waters of Aceh Besar. The most zones are in December as many as eight zones, namely in the Western, Northwest and East parts of Aceh Besar waters and the least found in July as many as one zone that is in the Western part of Aceh Besar waters. When compared to fishing operations areas, the potential fishing zone is in the western part of Aceh Besar waters.
Proximate composition and fatty acids profiling of Seahorse originated from Simeulue, Aceh-Indonesia
Authors: Abdullah Abbas Muhammadar , Karina Sofyatuddin , Qofifah Ririn , Nasir Muhammad , Asmawati Asmawati
Published: January 2022

The aim of this study was to determine the proximate composition, quantitative of fatty acids analysis as well as the content in the seahorse sample, Hippocampus sp which originated from Sibigo waters, Simeulue, Aceh, Indonesia. In this study, proximate composition and fatty acids of seahorse were determined. Based on the proximate analyses that had been conducted, results showed that protein was the most abundantly found in the seahorse (39.32±0.22%), orderly followed by carbohydrate (28.48±0.25%), ash (25.43±0.16%), moisture (6.29±0.13%) (dry weight basis) and fat (0.47±0.30%). Fatty acids profiling and analysis were also conducted by using the a GC-MS (Gas Chromatography-Mass Spectroscopy). The analysis result showed that sample possessed of saturated fatty acids in big size were palmitic acid, stearic acid, myristic acid, and lauric acid. While unsaturated fatty acids were arachidonic acid, linoleic acid and oleic acid. Traces of saturated fatty acids in small seahorse were found in the sample including palmitic acid, stearic acid, miristic acid and lauric acid, while unsaturated fatty acids were linoleic acid and oleic acid. The highest saturated fatty acid in seahorse was palmitic acid (60.67%), and unsaturated fatty acids were oleic acid (45.5%), arachidonic acid (25.08%) and linoleic acid (0.93%).
Understanding swarm earthquakes in Southeast Aceh, Sumatra
Authors: Simanjuntak Andrean V. H. , Kuncoro Djati C. , Irwandi Irwandi , Muksin Umar
Published: January 2022

The cause of the swarm earthquakes occurring from September until November 2020 remains unclear. The swarm activities are close to the Tripa active fault but also close to Mt. Bendahara. This study offers the analysis of seismic P and S wave arrivals and relocate the hypocenter of the swarm. We analysed the hypocentre distribution that recorded by Badan Meteorologi Klimatologi dan Geofisika (BMKG) from July 2020 to January 2021. The arrival of P and S-wave from 103 events was used obtain 1-D seismic velocity model. The earthquake used for this study consisted of at least 6 phases of seismic arrivals with the azimuthal gap angle less than 180 degree. The different velocities occurred in the upper and lower of the crustal thickness of 0 – 40 km. The Vp values are about 5.0 – 7.0 km/s and 3.0 – 5.0 km/s for Vs value while the Vp/Vs ratio are ranging from 1.5 to 1.7. Our preliminary results indicate that the potential swarm activities near to Mt. Bandahara maybe triggered by an unknown fault activity as no volcanic activity was reported.
Intellectual capital and islamic corporate social responsibility on the financial performance of sharia commercial banks in Indonesia
Authors: Sri Rahayu , Mahdi Fauzi , Julkarnain  , Triastuti Kurnia Heny Ningsih , Habibie Azwansyah
Published: January 2022

This study aims to examine Intellectual Capital, Islamic Corporate Social Responsibility on the Financial Performance of Islamic Commercial Banks in Indonesia based on the Islamicity Performance Index. The dependent variable is the Financial Performance of Islamic Commercial Banks in Indonesia based on the Islamicity Performance Index. The independent variables used in this study are Intellectual Capital and Islamic Corporate Social Responsibility. The population in this study is 14 Islamic banking companies. The sampling technique used purposive sampling, as many as 8 Islamic banking 2016-2019. The data were analyzed using Partial Least Square (PLS) tools. General Sharia based on Islamic City Performance Index with indicators of Equitable Distribution Ratio and Profit Sharing Ratio. Islamic Corporate Social Responsibility has no effect on the Islamic City Performance Index with indicators of Equitable Distribution Ratio and Profit Sharing Ratio.
Fiqh review on zakah of marine resources
Authors: Haridhi Mubarraq Hafiz , Fikriah Fikriah
Published: January 2022

The obligation of zakah for Muslims is imposed on valuable assets and it reaches the nishab level. The objectives of the shari'ah of zakah are to create an even distribution of income, avoid social inequality and raise the standard of living of the poor. Every asset that is obtained by a human being in the form of findings, results of efforts, work, gifts, and others that is fully owned, by achieving the nishab, must be paid its zakah. In classical fiqh, the classification of zakah maal is still limited, so that scholars continue to develop its classification with various legal istinbath methods. Zakah on marine resources also raises interpretations among scholars so that it needs to be studied from a fiqh perspective. Marine resources, both valuable goods and fisheries in large quantities which are used as sources of income and reach the nishab, need to be reviewed for its zakah regulation. This study is a literature review that reviews classical to modern zakah fiqh. This normative research found that marine resources that reach the nishab must be taken out as zakah for agriculture, commerce, mining, and others. Differences of opinion among scholars in arguing whether or not zakah on the sea resources is obligatory are based on the presence or absence of sources of livelihood from marine products at that time, so that differences in times led to differences of opinion. However, marine resources today have become a big source of livelihood for certain people. So that all forms of income that reach the nishab must be issued zakah. It can be concluded, that the zakah level of the traded marine products can be verified to commercial zakah or gold and silver zakah, which is 2.5%, or zakah on findings, which is between 2.5% and 20%, it depending on the type of resources obtained.
The effectiveness of TOEFL app for final-year students of Marine and Fisheries Faculty Universitas Syiah Kuala, Indonesia
Authors: Maulana Riyan , Irwan Irwan , Hanum Maila Cut , Mujiburrahman Mujiburrahman , Lidiana Lidiana
Published: January 2022

The paper reports the final-year students’ needs of English and its effectiveness in joining TOEFL Class conducted by Academic of FKP using TOEF FKP application in learning process. There were about 45 final-year students in the academic year 2020-2021 as the primary objects of this research. The researcher is qualitative research and administered questionnaires and interviews to collect data and constructed as. The results found that the students need English skill to face challenges in the future for their career. It was also found that there was a high demand for TOEFL Certificate as a proof as English capacity, as a graduation requirement in the faculty and as a tool in order to work in international maritime industries in Aceh. Therefore, most of the students placed English skill as their highest priority. This application can facilitate the process of learning English in particular because it utilizes technological developments in this case the android application where they have been introduced since childhood to them at home. It concluded that the results of this investigation should be taken into account in developing teaching, learning materials, improving the TOEFL FKP app and its regulation for marine students.
La maintenance prédictive a soif de data
Authors:   La rédaction
Published: January 2022

Comment exploiter les données à des fins de maintenance prédictive et ainsi optimiser la durée de vie des équipements ? L’innovation mise en place par EDF et Assystem à la centrale nucléaire de Flamanville vise à répondre, du moins en partie, à cette question.
Framatome met le numérique au service de la standardisation
Authors:   La rédaction
Published: January 2022

Pour répondre aux défis industriels liés à l’immense programme EPR 2 débutant par la construction de trois paires de réacteurs, Framatome déploie des outils numériques destinés à standardiser et à améliorer la qualité de ses produits. On parle de Product Lifecycle Management.
La simulation numérique au service du démantèlement
Authors:   La rédaction
Published: January 2022

Le Commissariat à l’énergie atomique et aux énergies alternatives (CEA) doit démanteler et assainir des structures de natures très diverses : laboratoires, ateliers, installations de R&D, etc. La tâche est d’autant plus compliquée que ces installations ont connu des modifications importantes au cours des dernières décennies, des changements qui ne sont pas toujours bien documentés. L’usage de maquettes numériques 4D et de la réalité virtuelle permet de préparer ces chantiers pour en optimiser la sûreté et les coûts.
La gestion des déchets radioactifs à l’ère du numérique
Authors:   La rédaction
Published: January 2022

Les différents acteurs du nucléaire intervenant dans la production ou la gestion des déchets radioactifs développent des outils pour assurer une continuité de l’information. Pour aller au-delà des initiatives des seuls sites ou entreprises, un collectif consacré aux déchets au sein de la Commission numérique du Groupement des industriels français de l’énergie nucléaire (Gifen) a été créé.
Weiterentwicklung der Reifegrade des Qualitäts – und
Risikomanagementsystems am Universitätsklinikum
Schleswig-Holstein
Authors: Soeth Edlyn , Hilbert Carsten , Scharffenberg Susanne , Wehkamp Kai , Rogge Annette , Kahla-Witzsch Heike , Freitag-Wolf Sandra , Scholz Jens , Petzina Rainer
Published: January 2022

Einleitung Konsekutiv zu unserer Publikation „Reifegrade des
Qualitäts- und Risikomanagementsystems am Universitätsklinikum
Schleswig-Holstein“ aus dem Jahr 2018 stellen wir die Weiterentwicklung
unseres Reifegradmodells vor. Qualitäts- und Risikomanagement (QRM) in
Krankenhäusern sind nicht nur gesetzlich gefordert, sondern
führen maßgeblich zu einer optimierten patienten- und
ablauforientierten Krankenversorgung.

Methode Durch einen strukturierten Erhebungsbogen zur Eigenbewertung
erfolgte an 46 Kliniken mit direkter Patientenversorgung an den beiden
Standorten des UKSH (Kiel und Lübeck) eine Analyse von insgesamt neun
Qualitätskriterien. Vier von diesen Kriterien
(Qualitätssicherung (QS), Critical Incident Reporting System (CIRS),
Beschwerdemanagement (BM) und Prozessmanagement (PM)) wurden bereits 2016
erhoben und in 2020 um fünf neue Aspekte erweitert – Audits und
Begehungen, Verantwortlichkeiten, Morbiditäts- und
Mortalitätskonferenzen, Hygieneschulungen und OP-Checklisten. Jedes
Qualitätskriterium wurde in vier Kategorien von A (voll implementiert)
bis D (nicht implementiert) eingeteilt.

Ergebnisse Im direkten Ergebnisvergleich der vier
Qualitätskriterien und des Gesamtreifegrades von 2016 und 2020 zeigten
sich statistisch signifikante Verbesserungen in 2020 in den Kriterien QS
(p=0,013), CIRS (p=0,026), PM (p=0,000) und dem
Gesamtreifegrad (p=0,019). Im Bereich BM wurden keine statistisch
signifikanten Unterschiede festgestellt, jedoch zeigte sich eine positive
Entwicklung. In den in 2020 zusätzlich erhobenen fünf
Qualitätskriterien wurden die Reifegrade A (voll implementiert) und B
(zum großen Teil implementiert) jeweils in folgenden
Häufigkeiten angegeben: Audits und Begehungen 100%,
Verantwortlichkeiten 95,6%, Morbiditäts- und
Mortalitätskonferenzen 65,2%, Hygieneschulungen 95,6%
und OP-Checklisten 100%.

Schlussfolgerung Das integrierte QRM ist seit Jahren fester Bestandteil am
UKSH. Die Wirksamkeitsüberprüfungen der initiierten
zielgerichteten Maßnahmen stellen jedoch eine Herausforderung dar. Aus
diesem Grund erscheint es notwendig, wirkungsvolle und ressourcenschonende
Ansätze für eine Evaluation von Maßnahmen und
für die Identifikation von Verbesserungspotentialen zu entwickeln. Die
erkannten Verbesserungspotentiale sollen risikopriorisiert und mit umsetzbaren
Maßnahmen ausgeschöpft werden. Diesen Grundsätzen
folgend konzipierten wir 2016 ein qualitatives Reifegradmodell zur Evaluation
des QRM-Systems am UKSH, dessen Weiterentwicklung wir hier aufzeigen.
„Aktiv leben mit Krebs – Tipps für einen
gesunden Lebensstil“ – Bedarfserfassung und Entwicklung einer
multimedialen Patienteninformation
Authors: van Eckert Sandra , Seidel Nadja , Stölzel Friederike , Wolff Michaela , Glausch Melanie , Spallek Jacob
Published: January 2022

Die positive Wirkung eines gesunden Lebensstils auf die ganzheitliche Verfassung
und Lebensqualität für Krebspatient*innen (Cancer
Survivors) ist wissenschaftlich belegt. Gemäß den National
Comprehensive Cancer Network (NCCN) Guidelines for Survivorship ist
Unterstützung in diesem Bereich ausdrücklich gefordert. Bei
hohem Unterstützungsbedarf für die Entwicklung und Umsetzung
eines gesunden Lebensstils gibt es jedoch, vor allem in ländlichen
Regionen, einen Mangel an spezialisierten Angeboten für
Krebspatient*innen. Nach Erfassung der Bedürfnisse war es unser
Ziel, eine leicht zugängliche, multimediale Patienteninformation auf der
Basis des sozial-kognitiven Prozessmodells des Gesundheitsverhaltens (Health
Action Process Approach – HAPA), zu konzipieren. Die Anhebung der
Gesundheitskompetenz steht u. a. als Basis für informierte
Entscheidungen, und ist damit eine wichtige Ressource für die
Krebsnachsorge. Weiterführende Erhebungen zur Akzeptanz, Nutzung und
Auswirkung der Patienteninformation hinsichtlich einer angestrebten,
längerfristigen Änderung des Gesundheitsverhaltens sind
empfohlen.
Existe alguma diferença entre um marcador esférico e uma moeda simples para planejamento digital de substituição de quadril?
Authors: Polesello Giancarlo Cavalli , Salerno Thiago Tronco , Queiroz Marcelo Cavalheiro de , Ricioli Junior Walter , Rabelo Nayra Deise Anjos , Honda Emerson Kyioshi
Published: January 2022

Objetivo Avaliar a precisão e as diferenças entre 2 tipos de marcadores metálicos, esfera e moeda, para calibração radiográfica no planejamento pré-operatório da artroplastia de quadril.

Métodos Quatro marcadores metálicos esféricos e quatro moedas, ambas de 25 mm de diâmetro, foram colocadas em trocânter maior, sínfise púbica, entre as coxas e a mesa do exame, para exame radiográfico do quadril em 33 pacientes com prótese de quadril. A cabeça da prótese foi utilizada para calibração e dois examinadores mediram os diâmetros da imagem dos marcadores, e os resultados foram analisados estatisticamente.

Resultados No trocânter maior, a esfera e a moeda não foram visualizadas em 19 radiografias (57,6%). Entre as coxas, o marcador de moeda não foi visualizado em 13 radiografias (39,4%). No trocânter maior, a precisão de 25 mm da moeda e da esfera foi, respectivamente, entre 57,1 e 63,3% e entre 64,3 e 92,9%. A moeda entre as coxas atingiu 25 mm de precisão entre 50 e 60%. Sobre a mesa de exame, os marcadores de moeda e esfera atingiram, respectivamente, diâmetros médios de 22,91 mm e 23 mm, o menor coeficiente de variação, o menor intervalo de confiança e o posicionamento mais fácil. Houve diferença estatística entre as avaliações dos marcadores (moeda vs. esfera) em todas as posições (p < 0,032), com exceção da posição na mesa de exame (p = 0,083).

Conclusões A moeda entre as coxas é o melhor marcador para calibração radiográfica no planejamento pré-operatório da artroplastia de quadril, e sugerimos o uso de outra moeda na mesa de exame para comparação, considerando os 8% de redução em relação ao seu tamanho real.
Tendinopatias do quadril: Uma atualização de conceitos e abordagens
Authors: Resende Vanessa Ribeiro de , Franco Yuri Rafael dos Santos
Published: January 2022

A presente atualização foi embasada nas novas evidências científicas das principais tendinopatias relacionadas ao quadril. Foram abordadas temáticas que envolvem os princípios do aparecimento das tendinopatias através, principalmente, do princípio da capacidade versus demanda e os aspectos biomecânicos envolvidos no seu aparecimento, suas principais características e apresentações clínicas. Associadas a isso, foram expostas as atualizações voltadas ao tratamento, com a terapia por exercício sendo o foco do tratamento conservador e as abordagens cirúrgicas necessárias para o controle ou resolução desses casos.
Applications of Ultrasound in the Postoperative Period: A Review
Authors: Long Emily , Maselli Amy , Barron Sivana , Morgenstern Monica , Comer Carly D. , Chow Kaimana , Cauley Ryan , Lee Bernard T.
Published: January 2022

Background Recent advances in ultrasound technology have further increased its potential for routine use by plastic and reconstructive surgeons.

Methods An extensive literature review was performed to determine the most common applications of ultrasound in the postoperative care of plastic and reconstructive surgery patients.

Results In contrast with other available imaging modalities, ultrasound is cost-effective, rapid to obtain, eliminates the need for ionizing radiation or intravenous contrast, and has virtually no contraindications. In addition to its diagnostic capabilities, ultrasound can also be used to facilitate treatment of common postoperative concerns conveniently at the bedside or in an office setting.

Conclusion This article presents a review of the current applications of ultrasound imaging in the postoperative care of plastic and reconstructive surgery patients, including free flap monitoring following microsurgery, diagnosis and treatment of hematoma and seroma, including those associated with BIA-ALCL, and breast implant surveillance.