bluuebunny/crossref_metadata_2025 huggingface dataset:
Research On Exercise Fatigue Estimation Method of Pilates Rehabilitation Based On ECG and sEMG Feature Fusion
Authors: Li Dujuan , Chen Caixia
Published: November 2021

Purpose. Fatigue estimation is of great significance to improve the accuracy of intention recognition and avoid secondary injury in Pilates rehabilitation. Surface electromyography (sEMG) is used to estimate fatigue with low and unstable recognition rates. To improve the rate, this paper fused electrocardiogram (ECG) signal and sEMG signal under three different states, and the classification model of the improved proved particle swarm optimization support vector machine (IPSO-SVM) algorithm was established. Methods. Twenty subjects performed 150 minutes of Pilates rehabilitation exercise. ECG and sEMG signals were collected at the same time. After necessary preprocessing, the IPSO-SVM classification model based on feature fusion was established to identify three different fatigue states (relaxed, transition, and tired). The model effects of different classification algorithms and different fused data types were compared. Results. Compared with common physiological signal classification methods such as BP neural network algorithm(BPNN), K-nearest neighbor(KNN), and Linear discriminant analysis(LDA), IPSO-SVM had obvious advantages in the classification effect of sEMG and ECG signals, the average recognition rate was 87.83%. The recognition rates of sEMG and ECG fusion feature classification models were 94.25%, 92.25%, 94.25%. The recognition accuracy and model performance was significantly improved. Conclusion. The sEMG and ECG signal after feature fusion form a complementary mechanism. At the same time, IPOS-SVM can accurately detect the fatigue state in the process of Pilates rehabilitation. This study establishes technical support for establishing relevant man-machine devices and improving the safety of Pilates rehabilitation.
Apolipoprotein E Gene Polymorphism Effects on Lipid Metabolism and Risk of Cerebral Infarction in Northwest Han Chinese Population
Authors: Ma Wenbing , Zhang Liting , Yang Shuang , Zhang Suya , Dong Haiyan , Li Houli , Dong Weihua , Lu Xiaoyun , Feng Weiyi
Published: November 2021

Background: The apolipoprotein E (ApoE) genetic variation may be involved in the development of Cerebral Infarction (CI). Serum lipid levels are known risk factors for CI, but the effect of the ApoE gene polymorphism on lipid metabolism remains unclear. This retrospective cohort study aimed to determine the role of ApoE genotypes in CI risk and the relationships between ApoE gene polymorphism and serum lipid levels among the population of northwest China.patients and methods: 517 CI patients and 517 non-CI controls were enrolled in the study. Polymerase chain reaction and hybridization were used to test the ApoE gene polymorphisms.results: Patients with CI had a significantly higher frequency of ε3/ε4 genotype (OR =2.057, 95% CI = 1.477–2.864, P<0.001) and ε4 allele (OR =1.818, 95% CI = 1.364–2.424, P<0.001) than control participants. When stratifying by age and sex, it was found that statistically significant differences in the distribution and frequencies of the ε3/ε4 genotype(OR =3.067, 95% CI = 1.675–5.614, P<0.001 in age ≤60 years; OR =1.735, 95% CI = 1.156–2.604, P=0.008 in age >60 years and OR =2.206, 95% CI = 1.474–3.301, P<0.001 in males) and ε4 allele (OR =1.709, 95% CI = 1.201–2.432, P=0.001) in males and ε4 allele (OR =2.072, 95% CI = 1.281–3.353, P=0.003 in age ≤60 years; OR =1.704, 95% CI = 1.189–2.444, P=0.003 in age>60 years; OR =1.709, 95% CI = 1.201–2.432, P=0.001 in males and OR =2.046, 95% CI = 1.246–3.361, P=0.004 in females ) were observed between patients and controls. ε4 carriers had significantly lower ApoE level and higher low-density lipoprotein cholesterol (LDL-C), ApoB and ApoB/ApoA-I levels than ε2 carriers in both two groups. Additionally, control participants with ε4 carriers had significantly higher levels of lipoprotein and lower total cholesterol (TC) levels than ε2 carriers, CI patients with ε4 carriers had significantly lower level of ApoA-I than ε2 carriers. After adjusting for other established risk factors, drinking, hypertension, lipoprotein, triglycerides (TG) and ε4 allele were significant independent risk factor for CAD. ε4 allele presence was associated with a nearly two-fold higher CI risk.Conclusions: This study provides evidence that ε4 allele, drinking, hypertension, lipoprotein and TG levels are independent risk factor for CI among patients in Northwest China. Also, these data might be clinically useful in allowing for more individualized preventive and therapeutic strategies.
Computational Discovery of a miRNA and its Putative Target Genes in Ziziphus Jujuba using Genome-wide Expressed Sequence Tags
Authors: Fernando Salpadoruge Sanjana Supun Tharaka , Zakeel Mohamed Cassim Mohamed , Safeena Mohamed Ismail Sithy
Published: November 2021

Background Ziziphus jujuba is an important fruit crop which is increasingly becoming popular among consumers due to its medicinal properties. Increasing worldwide demand for the fruit poses new challenges to the industry which includes the need for accelerated cultivar development of jujubes. To embark on cultivar development with improved traits such as high yield and disease resistance, molecular and conventional breeding, and genetic engineering become imperative. But inadequate trait-enhancing alleles or gene pleiotropism limit the direct use of several identified genes. To overcome these issues, microRNAs (miRNAs) can be utilized in breeding of jujubes as genetic modulators to fine-tune the regulation of gene expression, thus the discovery of miRNAs becomes important. Methods and results In this study using a computational approach, we identified one potential miRNA (zju-miR-215-3p) from 2904 expressed sequence tags. The miRNA showed down regulation of five target proteins (AP-2 complex subunit alpha, C2H2-type domain-containing protein, sentrin-specific protease 1, hydrolase_4 domain-containing protein and putative alpha-ketoglutarate-dependent dioxygenase) and their suppression appears to be helpful to the plant to overcome stress conditions. Conclusion The miRNA identified in this study is associated with five potential target proteins, most of which are implicated in metabolic and developmental processes associated with plant growth and reproduction. Future studies are necessary to validate the miRNA by RNA sequencing and to confirm the molecular functions of the down regulations of target proteins.
Reaction Kinetics Modelling for Dry Anaerobic Digestion of Hura Crepitans Invasive Species Lignocellulosic Biomass
Authors: Olugbemide Akinola David , Likozar Blaž , Oberlintner Ana , Novak Uroš , Lawrence Ekebafe
Published: November 2021

In this research study, the impact of the feedstock to the inoculum (F/I) amount ratio in the dry anaerobic digestion (DAD) of Hura crepitans leaves was evaluated. Measured biogas volumes, as well as the chemical kinetic predictions for exponential, logistic and Gompertz model, depicting the agreement of the simulations over time, were also determined. From the F/I equivalents 2, 4 and 6 at 22 % of packed total solids, which were considered in analysis test procedure, the DAD digester with F/I number 4 was the most promising in terms of biogas’ production rate. Its daily methane/carbon dioxide was 690 mL, while cumulative generation productivity was greater than 2 L/sample, respectively. On the other hand, the DAD reaction with F/I contained 6, recorded the lowest related expressed primary matter of < 1 L. An associated early commencement of the organic material breakdown in all bio vessels was indicative of a good start-up phase, which is one of the challenges, often encountered in DAD process. Furthermore, applied experimental methods revealed the direct correlation phenomena between biodegradability physical constants, measured molecular CH4/CO2 synthesis and simulations. Hura crepitans being an invasive plant species makes its lignocellulosic fractions desired in terms of valorisation, as it is not competing with agricultural crop products. Modelling can, moreover, contribute to consecutive operation optimisation, scaling and integrating, also taking dynamics under consideration. As opposed to bio-refining wood residues, where individual cellulose, hemicellulose or lignin biopolymers can be attained, degradation to yield CH4 is robust, as well as compatible in combustion.
Clinicopathological Features' Correlation and Genes’ Expression of NEAT1, lincRNA-ROR and Oct4 in Iranian Patients with Gastric Cancer
Authors: Chaleshi Vahid , Nourian Mahyar , Zamani Naghmeh , Mehrvar Narjes , Iravani Shahrokh , Jalaeikhoo Hasan , Vosough Massoud
Published: November 2021

Purpose

Long non-coding RNAs (LncRNAs) play a critical role in the initiation and development of Gastric Cancer(GC). The aim of this study was to consider the expression of NEAT1, lincRNA-ROR and Oct4 and finally evaluate the correlation between their expression and clinical characteristics in Iranian patients with GC.
Methods

This cross-sectional study was performed on 41 gastric tumor tissue samples with matched normal adjacent tumor tissues. The RNA level of lncRNA NEAT1 and lincRNA ROR and Oct4 genes were assessed using the quantitative Real-time polymerase chain reaction. B2M was used as an internal control. Also, the relative expression of lncRNA NEAT1 and lincRNA ROR compared Oct4 in GC tissues was evaluated. The 2 −ΔΔCq method was used to determine the expression fold changes.
Results

A significant association was observed between the levels of lincRNA ROR and Oct4 genes in gastric tumor tissues comparing normal adjacent tissues (Mean = 1.558, p= 0.014), (Mean = 3.337, p< 0.001) and (Mean= 4.385, p<0.001), respectively. In addition, clinicopathological data comparing with lncRNAs and Oct4 mRNA expression levels in gastric cancer tissues showed no significant association. Here, we found that significant association between the levels of lincRNA ROR expression comparing oct4 mRNA level in gastric cancer tissues (R=0.417; P=0.024).
Conclusion

Our results Showed that lincRNA ROR and Oct4 have a significant association in gastric cancer. Also, our results indicate the first suggestion that lincRNA ROR expression correlated with oct4 mRNA level in gastric cancer tissues.
Studies on the Efficient Dual Performance of Lyngbya Majuscula Extract With Manganese Dioxide Nanoparticles in Photodegradation and Antimicrobial Activity
Authors: P RAMESH , A RAJENDRAN , P Manogar
Published: November 2021

The authors have requested that this preprint be removed from Research Square.
The Genetic Control of Polyacetylenes Involved in Bitterness of Carrots (Daucus Carota L.): Identification of QTLs and Candidate Genes From the Plant Fatty Acid Metabolism
Authors: Dunemann Frank , He Wanying , Böttcher Christoph , Reichardt Sven , Nothnagel Thomas , Heuvelmans Paul , Hermans Freddy
Published: November 2021

Background

Falcarinol-type polyacetylenes (PAs) such as falcarinol (FaOH) and falcarindiol (FaDOH) are produced by several Apiaceae vegetables such as carrot, parsnip, celeriac and parsley. They are known for numerous biological functions and contribute to the undesirable bitter off-taste of carrots and their products. Despite their interesting biological functions, the genetic basis of their structural diversity and function is widely unknown. A better understanding of the genetics of the PA levels present in carrot roots might support breeding of carrot cultivars with tailored PA levels for food production or nutraceuticals.
Results

A large carrot F2 progeny derived from a cross of a cultivated inbred line with an inbred line derived from a Daucus carota ssp. commutatus accession rich in PAs was used for linkage mapping and quantitative trait locus (QTL) analysis. Ten QTLs for FaOH and FaDOH levels in roots were identified in the carrot genome. Major QTLs for FaOH and FaDOH with high LOD values of up to 40 were identified on chromosomes 4 and 9. To discover putative candidate genes from the plant fatty acid metabolism, we examined an extended version of the inventory of the carrot FATTY ACID DESATURASE2 (FAD2) gene family. Additionally, we used the carrot genome sequence for a first inventory of ECERIFERUM1 (CER1) genes possibly involved in PA biosynthesis. We identified genomic regions on different carrot chromosomes around the found QTLs, that contain several FAD2 and CER1 genes within their 2-LOD confidence intervals. With regard to the major QTLs on chromosome 9 three putative CER1 decarbonylase gene models are proposed as candidate genes.
Conclusion

The present study increases the current knowledge on the genetics of PA accumulation in carrot roots. Our finding, that carrot candidate genes from the fatty acid metabolism are significantly associated with major QTLs for both major PAs, will facilitate future functional gene studies and a further dissection of the genetic factors controlling PA accumulation. Characterization of such candidate genes will have a positive impact on carrot breeding programs aimed at both lowering or increasing PA concentrations in carrot roots.
Interaction between envelope protein of Jaagsiekte Sheep Retrovirus and Hippo signaling pathway is inferred from transcriptome analysis of naturally infected Ovine Pulmonary Adenomatosis
Authors: Duan XuJie , Yang Hui , Zhang Liang , Li Huiping , Sun Zhiwei Zhi , Du Xiaoyue , Zhang Pei , Chen Sixu , Liu Ran , Liu Shuying
Published: November 2021

Background

Ovine pulmonary adenomatosis (OPA) is a contagious lung epithelial tumor of sheep caused by jaagsiekte sheep retrovirus (JSRV), which causes severe economic losses for the sheep industry in the world. The specific oncogenic mechanism of JSRV is not yet clarified.

Methods

In this study, RNA was extracted from lung tissues of 3 naturally infected OPA cases and 3 healthy individuals for transcriptome sequencing (RNA-Seq). Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to confirm the sequencing data. Immunohistochemistry (IHC) and western blot (WB) were performed to confirm the signaling pathway enriched by DEGs that was activated in naturally infected OPA cases. Cell viability, wound-healing, transwell and colony formation assays were performed to assess the cell malignant transformation of sheep trophoblast cells (STCs) transformed with JSRV- env lentivirus in vitro, and then WB was performed to confirm the signaling pathway that had been validated in the lung tissues.

Results

A total of 366 DEGs (154 up-regulated and 212 down-regulated) were identified by RNA-Seq of lung tissues of naturally infected OPA cases and healthy individuals. GO analysis showed that 366 DEGs were significantly enriched in 178 GO terms, including 114 biological processes, 19 cellular components and 45 molecular functions. KEGG analysis showed that the DEGs mainly enriched in cell proliferation, differentiation, apoptosis and migration, such as PI3K/Akt/mTOR, MAPK and Hippo signaling pathway, and Hippo signaling pathway has never been reported in naturally infected OPA cases. qRT-PCR results of 10 DEGs which were selected randomly were consistent with RNA-Seq results. The protein expression of

Hippo signaling pathway were up-regulated in naturally infected OPA lung tissues.

Cell viability, wound-healing, transwell and colony formation assays confirmed that JSRV- env lentivirus caused malignant transformation of STCs and JSRV Env increased the protein expression of Hippo signaling pathway.

Conclusions

This research first identified the changes in the transcriptome level of naturally infected OPA lung tissues. These data confirm that the Hippo signaling pathway is involved in the mechanism of OPA, clarify the interaction between Hippo signaling pathway and JSRV Env, provide further evidence for the tumorigenic mechanism of JSRV.
Comparison of different risk stratification rules to predict short-term adverse outcomes after syncope in older Chinese adults
Authors: Mu Hong , Liu Jiexin , Tang Hefei , Huang Cheng , Liu Limin , Yang Tiecheng
Published: November 2021

Background: Older adults with syncope are commonly treated in the emergency department. Clinical decision rules have been developed to assess syncope patients, but there have been no application or comparative studies in older Chinese cohorts until now. This study aimed to compare the values of five existing rules in predicting the short-term adverse outcomes of older patients. Methods: From September 2018 to February 2021, older Chinese patients (≥60 yr) with syncope admitted to our hospital were investigated and evaluated by the Risk Stratification of Syncope in the Emergency Department (ROSE) rule, the San Francisco Syncope Rule (SFSR), the FAINT rule, the Canadian Syncope Risk Score (CSRS) and the Boston Syncope Criteria (BSC). After a one-month follow-up, the sensitivity, specificity, accuracy, positive predictive values (PPV), negative predictive values (NPV), positive likelihood ratios (PLR), and negative likelihood ratios (NLR) of each aforementioned rule were calculated and compared. Results: A total of 171 patients, with a mean age of 75.65±8.26 years and 48.54% male, were analysed in the study. Fifty-eight patients were reported to have experienced short-term adverse incidents during the month. The neurally mediated syncope group showed a significant sex-specific difference in adverse incidences but the cardiac syncope group did not. There were some factors associated with significant differences in adverse incidences, such as a history of hypertension, congestive heart failure, and chronic obstructive pulmonary disorder, as well as the levels of SpO2, B-type natriuretic peptide (BNP) and troponin T (TnT), while the levels of haemoglobin and creatinine suggested potential significance. In order of the ROSE, SFSR, FAINT, CSRS and BSC rules in the analysis, the sensitivities were 81.03%, 77.59%, 93.10%, 74.14% and 94.83%, the specificities were 86.73%, 84.96%, 38.94%, 60.18% and 56.64%, the NPVs were 89.91%, 88.07%, 91.67%, 81.93% and 95.52%, and the NLRs were 0.22, 0.26, 0.18, 0.43 and 0.09, respectively. Conclusions: This study revealed that the five mentioned rules for syncope risk stratification, with their own characteristics, all showed crucial significance for screening older adults. Therefore, physicians in the emergency department should flexibly understand and judge older patients’ potential risks according to the actual clinical situations.
Abundance and distribution of microplastics in water and sediment of Baiyangdian Lake, Northern China
Authors: Fang Yanyan
Published: November 2021

Microplastics (MPs) have been found in all environment matrices and have become an issue of concern worldwide. In this study, Baiyangdian Lake in Northern China was investigated for the presence of MPs (0.45 µm–5 mm) in sediment and at different water depths. MPs were found at 1,000–20,000 pieces/m3 (average 9,595) in water and at 400–2,200 pieces/kg (average 1,023) in sediment. Since the implementation of pollution abatement measures, visible MPs have been nearly eliminated; the MPs found in this study were mainly in the micrometer range, with no more than 3–5 pieces greater than 1 mm per sample. The main forms of MPs were fibrous and fragmented, and the main components were polyamide, polyethylene, and polypropylene. MPs found in water near a garbage transfer station showed the following abundance of MPs: surface water < middle water < bottom water. The sediment contained a higher amount of MP fragments, indicating that the historical transfer and disposal of garbage was a main source of plastic deposition in this area. There was a high content of fibrous MPs in surface water, while the abundance of fragmented MPs increased with the depth of water. The main sources of MPs in the study area were residential activities, local plastic factories, and the treated effluent from a sewage treatment plant.
Hemorrhagic Transformation in Patients With Large-artery Atherosclerotic Stroke Is Associated With Gut Microbiota and LPS-TLR4 Signaling Pathway
Authors: Huang Qin , Wei Min-Ping , Feng Xian-Jing , Yu Fang , Liao Di , Liu Ze-Yu , Luo Yun-Fang , Zhao Ting-Ting , Tu Ru-Xin , Huang Qing , Liu Yun-Hai , Jian xia
Published: November 2021

Objective: Hemorrhagic transformation (HT) is a major complication of ischemic stroke that worsens outcomes and increases mortality. Disruption of gut microbiota is an important feature of stroke, and some special bacteria combined with bacterial metabolites may contribute to HT pathogenesis. we aimed to study the relationship between gut microbiota and HT of large-artery atherosclerotic stroke. Methods: From May-2020 through September-2021, the blood and fecal samples in patients with acute first-ever ischemic stroke and not undergoing intravenous thrombolysis or endovascular were obtained on admission, and gut microbiota was assessed by 16s ribosomal ribonucleic acid (rRNA) sequence. Stroke that developed HT (n=15) were compared to those without HT (n=17) and healthy controls (n=16). We also examined the key components of lipopolysaccharide (LPS) pathway: LPS, LPS-binding protein (LBP), and solube CD14 (sCD14). The role of gut microbiota in HT was evaluated using experimental stroke model. Results: We observed that bacterial diversity was decreased in both HT and non-HT group compared to the healthy controls. The patients of ischemic stroke that developed HT had differential composition of gut microbiota, in particular, an increase in the relative abundance and diversity of members belonging to the Enterobacteriaceae family. Plasma LPS and LBP levels were higher in HT group compared to non-HT group. The concentrations of LPS, LBP and sCD14 were associated with increased abundance of Enterobacteriaceae. In experimental study, the antibiotics treatment diminished HT-induced increase in the levels of LPS and LBP as well as upregulated expression of Toll-like receptor 4 (TLR4) and NF-κB in colon tissue. Transplant of microbiota from HT rats triggered higher level of LPS, LBP and sCD14 in plasma and increased expression of TLR4 and NF-κB in colon tissue.Conclusion: Stroke patients who developed with HT exhibit an obvious change in gut microbiota and LPS-induced inflammatory response. This suggests that maintaining a balance of gut microbiota may be an important factor in preventing HT after stroke.
Elastic Settlement Analysis of Rigid Footings Relying On The “Characteristic Point” Concept
Authors: Pantelidis Lysandros
Published: November 2021

In the present paper, the problem of finding the location of the so-called “characteristic point” of flexible footings is revisited. As known, the settlement at the characteristic point, is equal to the uniform settlement of the respective rigid footing. The cases of infinitely long strips and circular footings are studied fully analytically. For the case of rectangular footings, analytical results (for flexible footings) are compared with the respective numerical results (for rigid footings) obtained from 3D finite element analysis (210 cases were examined). As shown, the location of the characteristic point may greatly deviate from the well-known values reported in the literature, as it strongly depends on the thickness and Poisson’s ratio value of the compressible medium. For rectangular footings this location also depends on their aspect ratio, L/B. The location of the characteristic point with respect to the center of footing for the various cases examined is given in tabular form. Strain influence area values (Aj=ρjEs/qB) are also given for the convenient calculation of the settlement (ρj) of footings, especially the rigid, rectangular ones; q is the uniform surcharge of footing and Es the soil modulus.
Focused Ultrasound and RadioTHERapy for Non-Invasive Palliative Pain Treatment in Patients with Bone Metastasis: A Study Protocol for the Three Armed Randomized Controlled FURTHER-trial
Authors: Bartels Marcia , Ferrer Cyril , Bos Clemens , Bartels Lambertus , Boomsma Martijn , Slotman Derk , Phernambucq Erik , Nijholt Ingrid , Morganti Alessio , Siepe Giambattista , Buwenge Milly , Gruell Holger , Bratke Grischa , Yeo Sin Yuin , Blanco Roberto , Minn Heikki , Huhtala Mira , Napoli Alessandro , de Felice Francesca , Catalano Carlo , Bazzocchi Alberto , Gasperini Chiara , Campanacci Laura , Galendi Julia , Mueller Dirk , Braat Manon , Moonen Chrit , Verkooijen Helena
Published: November 2021

Background

Cancer Induced Bone Pain (CIBP), caused by bone metastases, is a common complication of cancer and strongly impairs quality of life (QoL). External Beam RadioTherapy (EBRT) is the current standard of care for treatment of CIBP. However, approximately 45% of patients have no adequate pain response after EBRT. Magnetic Resonance image guided High Intensity Focused Ultrasound (MR-HIFU) may improve pain palliation in this patient population.
Methods/design:

The FURTHER trial is an international multicenter, three-armed randomized controlled trial. A total of 216 patients with painful bone metastases will be randomized in a 1:1:1 ratio to receive EBRT only, MR-HIFU only, or combined treatment with EBRT followed by MR-HIFU. During a follow-up period of six months, patients will be contacted at eight time points to retrieve information about their level of pain, QoL and the occurrence of (serious) adverse events. The primary outcome of the trial is pain response at 14 days after completion of treatment. Secondary outcomes include pain response at 14 days after trial enrolment, pain scores (daily until the 21st day, weekly until the 6th week and monthly until the 6th month), toxicity, adverse events, QoL, and survival. Cost-effectiveness and cost-utility analysis will be conducted.
Discussion

The FURTHER trial aims to evaluate the effectiveness and cost-effectiveness of MR-HIFU – alone or in combination with EBRT – compared to EBRT to relieve CIBP. The trial will be performed in six hospitals in four European countries, all of which are partners in the FURTHER consortium.
Trial registration:

The FURTHER trial is registered under the Netherlands Trials Register number NL71303.041.19 and ClinicalTrials.gov registration number NCT04307914. Date of trial registration is 13-01-2020.
Transmen Individuals Have Hyperandrogenism Related Metabolic Changes Compared Ciswomen: Case Controlled Study
Authors: Erel Pınar , Elbasan Onur , Yorguner Neşe , İmre Eren , ÜSTAY Özlem
Published: November 2021

Introduction

: This study aims to evaluate metabolic parameters and hormonal profiles of transmen individuals who are referred from psychiatry outpatient clinic, compared to natal women.
Method

This study is designed as a single-center observational cohort study. Seventy drug-naive female to male transgender individuals (FtoM) and 34 healthy natal women for the control group were included. Hormone profile and metabolic parameters were measured and compared between the two groups.
Results

Sixteen of the 70 FtoM individuals meet Rotterdam criteria and are diagnosed with PCOS (22,85%), on the other hand in 4 individuals in the control group meet the criteria (11,7%). Although there wasn't any significant difference between the two groups weight and BMI; total testosterone, triglyceride, FAI, androstenedione, 17-OH progesterone, muscle strength, HOMA-IR levels were significantly higher in the transmen group and HDL levels were significantly higher in the control group (p values 0.001, 0.007, 0.013, 0.011, 0.001, 0.004 respectively.)
Conclusion

This is the first case-controlled study that compared anthropometric, metabolic, and endocrinological parameters of transmen individuals with cis women. In our study, we showed that even when PCOS patients were excluded, hyperandrogenemia continues in these individuals compared to cis women. It is clear that transmen individuals have higher androgen levels which may have been the reason for increased muscle strength, insulin resistance, and dyslipidemia compared to natal women. But the main reason for hyperandrogenism in drug-naïve transmen individuals is still not known and more comprehensive further studies are needed.
Energy and Heat for Medium-sized Cities in a Temperate Climate From a Small Nuclear Reactor and Solar Panels
Authors: Janczyszyn Jerzy , Jaskólski Marcin
Published: November 2021

The article discusses the possibilities of using a system consisting of small nuclear reactors, solar collectors and a heat accumulator in future carbon-free conditions. Kraków (Poland) was chosen as an example of a city supplied with electricity, and heat from the discussed system. The demand for electricity and heat was estimated, possible technical solutions were proposed in an approximate manner and monthly balances of electricity and heat were calculated. It was found impossible to meet the energy needs by using only renewable sources in specific conditions of moderate and season-dependent intensity values of sun and wind. The only and efficient option that is able to cover the city's demand for electricity and heat is a nuclear power plant, consisting, for example, of NuScale nuclear units in combination with solar collectors and a properly selected heat accumulator. Fifty MWel reactors were considered, but a new version of the NuScale modular reactor with a modular capacity of 77 MWel is also briefly shown.
Longitudinally Extensive Transverse Myelitis (LETM) in COVID-19 Infection, A Case-Report
Authors: Cutsem Jean-Christophe Van , Lamon Ann-Sophie , Belleghem Vincent Van , Vancaester Evelien
Published: November 2021

IntroductionSince the COVID-19 pandemic, a growing number of central nervous system (CNS) complications in patients with COVID-19 have been reported. Isolated, longitudinally extensive transverse myelitis (LETM), is a unique presentation of CNS involvement. The limited reports, its diverse clinical manifestations and the possible long-term consequences make the reporting crucial to further our understanding of those syndromes occurring in COVID-19 positive patients.Case PresentationA 63-year old male consulted the emergency department after a sudden onset of gait ataxia, a one-week history of paresthesia progressing from the feet to the midsternal area and urinary. He tested positive on a SARS-CoV-2 RNA RT-PCR nasopharyngeal swab two days prior to the onset of his symptoms. Neurological examination showed a sensory level at T7 with symmetrically reduced fine touch, vibration, proprioception and furthermore an ataxic gait was observed. Cerebrospinal fluid on day one of admission showed pleocytosis, predominantly neutrophils, elevated protein count and normal glucose level and IgG. MRI of the spinal cord revealed a diffusely increased signal intensity involving the near-complete spinal cord, from the brainstem to level T12, fitting the diagnosis of LETM. ConclusionThe few cases of transverse myelitis in association with COVID-infection are believed to have an immune-mediated postinfectious mechanism. In this case however, parainfectious direct viral invasion of the spinal cord is far more likely because of a neutrophilic predominance in CSF and a short timespan between infection and symptoms. It could provide more clues that the SARS-CoV-2 is acutally capable of causing direct neurotoxic effects.
Dynamic Pollution Emission Prediction Method of a Combined Heat and Power System Based on the Hybrid CNN-LSTM Model and Attention Mechanism
Authors: Wan Anping , Yang Jie , Chen Ting , Jinxing Yang , Li Ke , Qinglong Zhou
Published: November 2021

The prediction of pollution emission from a combined heat and power (CHP) system is very important for the production regulation and emergency response of a power system. The composition and structure of the CHP equipment are complex, and the production process is cumbersome. The fuel chemical reaction of the pulverized coal in the boiler represents a highly nonlinear and strongly interrelated process that is strongly affected by external environmental factors, which causes a certain level of volatility and uncertainty. In this study, a pollution emission prediction method of CHP systems based on feature engineering and a hybrid deep learning model is proposed. Feature engineering performs multi-step preprocessing on the original data, refines the correlation factors, and removes redundant variables. The hybrid deep learning model has a multi-variable input and is established by combining the convolutional neural network-long short-term memory network with the attention mechanism. The case study is conducted on the collected actual dataset. The influence of the prediction target periodicity on the prediction results is analyzed seasonally to verify the effectiveness of the hybrid model. The results show that the root mean square error of the proposed method is less than one, and the error is reduced compared to the other basic methods, which proves the superiority of the proposed pollution emission prediction method over the existing methods.
Onlife-Lehre in Corona-Zeiten? Reflexionen über eine hochschulübergreifende Ringvorlesung zum thematischen Dreieck musikkulturelle Bildung – Digitalisierung – Inklusion.
Authors: Pätzold Frank , Henning Ina , Niediek Imke
Published: November 2021

Der vorliegende Beitrag befasst sich mit Potentialen eines neuen Lehr-Lernformats für lehramtsbezogene Studiengänge in Form einer hochschulübergreifenden Ringvorlesung, die zwischen analogen und digitalen Formaten alterniert. Die inhaltliche Konzeption der Ringvorlesung bewegt sich im Themenfeld musikkulturelle Bildung – Digitalisierung – Inklusion. Erste Auswertungen von Erfahrungen lassen Momente entlang der Zusammenhänge des Onlife oder Postdigitalen erkennen. Deutlich wird aber auch, dass ein gemeinsamer konjunktiver Erfahrungsraum durch die Verflechtung von digitalen und analogen Anteilen im Jetzt und in der Zukunft im Sinne einer Bildungspraxis immer wieder neu konstituiert und ausgehandelt werden muss.
Lehramtsstudierende gestalten Erklärvideos für Grundschulkinder.
Authors: Ade Larissa , Pohlmann-Rother Sanna
Published: November 2021

Universitären Lehr-Lerngelegenheiten mit schulischem Praxisbezug wird besonderes Potenzial zur Förderung einer reflexiven Grundhaltung von angehenden Lehrkräften zugeschrieben. Im Kontext medienpädagogischerÜberlegungen gelten Lehrformate, die einen Theorie-Praxis-Transfer ermöglichen auch zur Weiterentwicklung medienpädagogischer Kompetenzen durch eine praxisnahe Erprobung von Unterricht mit digitalen Medien als vielversprechend. Im Würzburger Projekt PLUS@Wü wurde im Jahr 2020 ein Uni-Klassenzimmer an einer städtischen Grundschule eröffnet, das den Studierenden an der Schnittstelle von Universität und Schule Möglichkeiten zur medienpädagogischen Professionalisierung bietet. Mit der Corona-bedingten digitalen (Um-) Gestaltung medienpädagogischer Lehrveranstaltungen in der Uni-Klasse wurden herausfordernde Aufgaben und neue Chancen beispielsweise hinsichtlich der Initiierung des Theorie-Praxisbezugs sichtbar. Statt einer Unterrichtsstunde plantenund gestalteten die Studierenden in diesen Lehrveranstaltungen Erklärvideos, die von den Lehrkräften der Grundschule im Distanzunterricht eingesetzt werden konnten. Im Beitrag werden die Evaluationen der Lehrveranstaltungen aus der Perspektive der Studierenden und beteiligten Lehrkräften dargestellt. Anschließend rücken die Potenziale dieser Lehrformate sowohl für die medienpädagogische Professionalisierung von Lehramtsstudierenden als auch für die Gestaltung künftiger Lehrveranstaltungen im Präsenzformat in den Fokus.
Tagungsbericht: 13. Magdeburger Theorieforum
Authors: Schmidt Jennifer
Published: November 2021

Das 13. Magdeburger Theorieforum an der Otto-von-Guericke Universität hatte dieses Jahr den inhaltlichen Schwerpunkt „Bilder- und Bildpraxen im Kontext digital-vernetzer Kulturen“. Im veröffentlichten Call for Papers1 regten die Organisator*innen dazu an, das Verhältnis von Bildern, Bildpraxen und Digitalisierung sowie den Zusammenhang von fotografischen Technologien, Praktiken, Infrastrukturen und spezifischen Formen der Subjektivierung zu beleuchten. Zentrale Leitfrage war das Verhältnis von Bildern/Fotografie, Bildpraxen und Digitalisierung für sozial-, medien-, kultur- und bildungswissenschaftliche Forschung und Theoriebildung. Außerdem wurde nach den theoretischen und methodischen Zugängen zu gegenwärtigen Phänomenen digital-vernetzter Fotografie und Bildpraxen gefragt. Damit bot das Forum die Möglichkeit, das Zusammenspiel von Fotografie und Digitalisierung sowie aktuellen Bildpraxen und visuellen Formen der Kultur und Kommunikation zu reflektieren und diskutieren.
Pengenalan Konsep Ergonomi Dapur Kepada Ibu- Ibu PKK Kelurahan Sukawarna Kecamatan Sukajadi Kota Bandung dengan Pendekatan Edukatif dan Partisipatif
Authors: Novi  , Elty Sarvia  , Wawan Yudiantyo  , Winda Halim  , Christina
Published: November 2021

Saat ini pandemi Covid 19 yang masih menjangkiti hampir semua negara di dunia menyebabkan perubahan besar pada gaya hidup. Sekarang orang cenderung lebih memperhatikan asupan makanan dan kebersihannya. Selain itu, karena banyak menghabiskan banyak waktu di rumah maka muncul kebiasaan baru pula, salah satunya adalah kegiatan memasak di dapur. Berdasarkan survei yang dilakukan, 87% peserta menghabiskan waktunya lebih dari 1 jam di dapur. Tetapi sayangnya, masih banyak ketidaktahuan tentang bagaimana kondisi dapur yang ergonomis. Hal ini terbukti dari kuesioner yang diisi sebelum penyampaian informasi dilakukan. Seluruh peserta yang berjumlah 15 orang yang berasal dari PKK Kelurahan Sukawarna Kecamatan Sukajadi Kota Bandung belum mengenal istilah ergonomi dan penerapannya di dapur. Pengabdian masyarakat ini bertujuan untuk mengenalkan konsep ergonomi dapur kepada ibu-ibu PKK sehingga mereka dapat bekerja dengan lebih aman, sehat, nyaman, efektif, dan efisien. Metode yang digunakan adalah dengan pendekatan edukatif berbentuk webinar yang dilaksanakan secara daring. Kemudian, dilanjutkan dengan pendekatan partisipatif dengan memberikan kesempatan pada peserta untuk mengevaluasi dapurnya saat ini. Melalui edukasi yang disampaikan terlihat hasil berupa peningkatan pengetahuan peserta terkait konsep ergonomi dapur dan peserta dapat menjawab pertanyaanpertanyaan terkait penerapan ergonomi di dapur dengan lebih baik. Serta melalui pendekatan partisipatif yang dilakukan peserta menyadari kekurangan dapurnya saat ini. Hasil yang diharapkan adalah para peserta dapat lebih memperhatikan kondisi dapurnya sehingga dapat bekerja di dapur dengan lebih aman dan terhindar dari bahaya kecelakaan kerja.
Pengayaan Pengetahuan Investasi Digital Melalui Webinar Investasi dalam Era High Tech
Authors: Doro Edi  , Yenni Merlin Djajalaksana  , Julianti Kasih
Published: November 2021

Tren investasi telah berubah secara signifikan akibat imbas keberadaan pandemi COVID-19. Investasi tradisional seperti tabungan dan deposito tampak tidak lagi semenarik sebelumnya. Ledakan teknologi yang diakibatkan oleh adanya pandemi, mempromosikan berbagai investasi gaya baru menggunakan teknologi seperti saham, cryptocurrency, dan emas yang bisa dikelola melalui aplikasi daring. Meski investasi untuk ketiga jenis ini sudah menjadi perbincangan viral di Tanah Air, banyak orang Indonesia yang masih memiliki pengetahuan dan keterampilan yang terbatas di era baru investasi. Fakultas Teknologi Informasi Universitas Kristen Maranatha Indonesia bermaksud melaksanakan Corporate Social Responsibility melalui Program Pengabdian Masyarakat dengan mendidik masyarakat Indonesia tentang topik di era baru investasi digital, dan secara khusus ingin mempertimbangkan faktorfaktor apa pun yang terkait dengan investasi di saham, cryptocurrency, dan emas dengan cara yang benar. Niat ini telah diwujudkan dengan mengadakan Webinar Gratis yang terbuka untuk semua orang di Indonesia meskipun tidak terbatas hanya untuk mereka yang ada di Indonesia dengan topik “The Investment Puzzle: Stocks, Cryptocurrency, or Gold In The High Tech Era”. Webinar ini telah terlaksana pada hari Sabtu, 19 Juni 2021 melalui Aplikasi Zoom dan disiarkan juga melalui YouTube Channel Fakultas Teknologi Informasi Universitas Kristen Maranatha. Jumlah pendaftar mencapai 898 orang namun yang hadir dalam realisasinya adalah 462 peserta dari segala jenis kalangan dan masyarakat luas. Selain telah terpublikasi melalui YouTube, acara Webinar ini juga telah terpublikasi dalam bentuk berita di MCU News dan artikel di Kompasiana.
Edukasi dan Sosialisasi tentang Adversity Quotient dalam Upaya Pengembangan Kepemimpinan Diri Bagi Staff Kelurahan X, Kecamatan Y, Kota Bandung
Authors: Elty Sarvia  , Wawan Yudiantyo  , Kartika Suhada  , Christina
Published: November 2021

Siapapun sebenarnya bisa jadi pemimpin. Tiap orang mempunyai talenta, keterampilan dan keahlian tertentu yang tidak dipunyai oleh orang lain. Seorang pemimpin dibutuhkan untuk mengatur organisasi menjadi lebih baik, efektif dan efisien. Mengembangkan potensi menjadi seorang pemimpin berarti mengubah sebagian untuk diri kita, seperti memperbaiki kelemahan kita, mengubah karakter diri menjadi lebih baik dan positip, cara pandang yang baik dan luas , dan memiliki kemampuan dan keahlian untuk memimpin. Tujuan dari kegiatan ini adalah memberikan pemahaman lebih jauh bagi staff di kelurahan X bahwa pemimpin yang berhasil perlu mempunyai karakter kepemimpinan yang baik. Salah satunya adalah Adversity Quotient (AQ), yaitu kemampuan bertahan dalam menghadapi kesulitan dan mengatasinya. Metode yang digunakan adalah dengan pendekatan edukatif dengan memberikan pelatihan secara offline dan pemutaran video. Kegiatan edukasi dan sosialisasi ini di adakan dengan cara membagikan kuesioner terlebih dahulu di awal acara dan dilanjutkan dengan presentasi oleh tutor. Diakhir acara, hasil dari kuesioner AQ tadi akan diumumkan kepada peserta sehingga di harapkan dapat memberikan masukan kepada peserta apa saja kekurangan dan kelebihaan yang dimilikinya. Sebanyak 78 % peserta masih berada di kategori moderately AQ (Adversity Quotient) dan hanya 22 % berada di kategori moderately high AQ.
Penyusunan Rancangan Desain Dokumen Dan Laporan Keuangan Jujur Ministry Menuju Transparansi Keuangan
Authors: Santy Setiawan  , Se Tin  , Aurora Angela  , Sondang Mariani Rajagukguk  , Candra Sinuraya  , Anthonius  , Barnabas Tridig S.  , Frederick Ruben Hartanto  , Stefani Chendana
Published: November 2021

Pandemi Covid 19 yang melanda saat ini berimbas pada keadaan perekonomian Indonesia, bahkan mempengaruhi kehidupan ekonomi masyarakat Indonesia. Banyak masyarakat Indonesia saat ini yang kehilangan pekerjaan dan hidup di bawah garis kemiskinan. Jujur Ministry didirikan dengan maksud untuk membantu masyarakat yang terkena dampak Covid 19 dengan memberikan sarapan gratis bagi masyarakat yang tidak mampu, dan dalam jangka panjang memiliki rencana untuk memberikan bantuan dalam bidang pendidikan dan renovasi rumah. Pendiri Jujur Ministry memiliki keinginan untuk memiliki pencatatan laporan keuangan yang transparan untuk memberikan pertanggungjawaban kepada para donatur. Budaya kejujuran dan rasa kemanusiaan yang melatarbelakangi diselenggarakannya pengabdian masyarakat kepada Jujur Ministry. Tujuan pengabdian masyarakat yang dilakukan oleh tim pengabdi yang terdiri dari dosen Program Studi Akuntansi di Fakultas Bisnis Universitas Kristen Maranatha adalah membantu dalam pembuatan desain kegiatan, dokumen akuntansi dan laporan keuangan untuk Jujur Ministry. Pengabdian masyarakat menggunakan metode wawancara kepada pendiri Jujur Ministry dan dilakukan secara bertahap mulai dari wawancara kegiatan yang dilakukan Jujur Ministry, menyusun desain kegiatan dan dokumen akuntansi, serta menyusun desain laporan keuangan untuk Jujur Ministry. Tahapan terakhir tim pengabdi melakukan presentasi hasil kepada pendiri Jujur Ministry. Hasil dari pengabdian masyarakat ini berupa desain poster kegiatan yang dilakukan, desain dokumen akuntansi untuk kegiatan yang dilakukan, dan desain laporan keuangan yang disusun untuk Jujur Ministry. Tim pengabdi berharap pengabdian yang sudah dilakukan dapat membantu pendiri Jujur Ministry dalam mempertanggungjawabkan keuangan dan kegiatan yang dilakukan kepada para donatur secara transparan.
Pemberdayaan Kelompok Tani dan Pengembangan Kampung Sayur Bausasran di Masa Pandemi Covid 19
Authors: Dwi Aditiyarini  , Catarina Aprilia Ariestanti  , Aniek Prasetyaningsih  , Timothy Charles Wherrett  , Hardo Firmana Given Grace Manik  , Katon Wijana
Published: November 2021

Kampung Sayur Bausaran merupakan salah satu daerah percontohan dalam pertanian perkotaan di Kota Yogyakarta. Akan tetapi, kondisi pandemi Covid 19 menyebabkan penurunan produktivitas dan keterlibatan masyarakat dalam pertanian perkotaan ini. Melihat kondisi tersebut, civitas akademika UKDW tergerak untuk terlibat dalam keberlangsungan pertanian perkotaan di Bausasran. Program pengabdian ini bertujuan untuk memberdayakan 6 kelompok tani dan 1 lahan Gerakan Pekarangan Pangan di Kampung Bausasran melalui pembinaan sumber daya manusia, usaha, lembaga dan lingkungan. Pendekatan yang digunakan dalam program pengabdian ini meliputi pelatihan, penerapan dan simulasi pengetahuan dan teknologi. Kegiatan diawali dengan survey dan pemetaan kebutuhan masingmasing kelompok tani melalui wawancara secara langsung dengan pengurus kelompok tani. Berdasarkan hasil survey dan wawancara, terdapat perbedaan kebutuhan masingmasing kelompok tani berdasarkan kondisi, lokasi dan luas lahan pertanian. Meskipun demikian, program utama yang dibutuhkan masih terkait dengan pertanian. Metode bercocok tanam hidroponik secara sederhana menjadi salah satu solusi bagi pertanian perkotaan. Program pendukung meliputi usaha memperindah Kampung Sayur dan perbaikan manajemen serta administrasi. Program tersebut ditujukan untuk mengembangkan Kampung Sayur ke arah kawasan ekowisata berbasis edukasi pertanian. Pelaksanaan program ini disambut baik oleh perangkat desa dan pengurus kelompok tani. Lorong sayur yang hijau, diversifikasi produk olahan dan ketersediaan website dan media sosial untuk promosi merupakan bentuk pengembangan kelompok tani. Evaluasi dan perbaikan yang perlu dilakukan adalah pemetaan potensi kelompok tani yang lebih dalam dan rinci sehingga keunggulan dan potensi lokal yang ada dapat dikembangkan. Selain itu, diperlukan program pembinaan sumber daya manusia untuk meningkatkan motivasi masyarakat dalam memajukan pertanian perkotaan.
Transfer Teknologi Pengeringan Daun Pegagan untuk Masyarakat Desa Bedono, Kecamatan Jambu, Kabupaten Semarang
Authors: Victoria Kristina Ananingsih  , Cynthia Andriani  , Sumardi  , Bernardine Agatha Adi Konstantia
Published: November 2021

Kelompok masyarakat Raket Suket Desa Bedono, Kecamatan Jambu, Kabupaten Semarang, telah mengumpulkan data tanaman rumput yang tumbuh di kebun Desa Bedono. Kelompok Raket Suket mempunyai keterbatasan pengetahuan tentang kandungan gizi dan fitokimia tanaman rumput, serta pengolahan tanaman rumput menjadi minuman herbal, sehingga memerlukan pendampingan dari tim pengabdian masyarakat Fakultas Teknologi Pertanian Unika Soegijapranata (FTP). Kegiatan diawali dengan survey tanaman rumput di Desa Bedono. Studi pustaka dilakukan terhadap 5 tanaman rumput yang banyak tumbuh dan sering dikonsumsi oleh masyarakat Desa Bedono. Pengolahan dilakukan terhadap tanaman rumput yaitu pegagan (Centella asiatica), dengan cara pengeringan untuk membuat minuman herbal kering daun pegagan. Pengujian parameter kualitas dari minuman herbal pegagan kering dilakukan di Laboratorium yaitu kandungan antioksidan dan total fenol. Hasil studi pustaka dan analisa di Laboratorium (pengujian parameter kualitas) disampaikan kepada perwakilan Kelompok Raket Suket Desa Bedono dalam Transfer Teknologi (online) Pengeringan Daun Pegagan. Kelompok Raket Suket Desa Bedono selanjutnya dapat menerapkan teknologi pengeringan daun pegagan untuk produksi minuman herbal kering yang selanjutnya dapat dipasarkan ke masyarakat luas.