bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship Between Hemoglobin Levels and Leukocyte Count On Stunting Incidence In Tanjung Agung Puskesmas, Muara Enim 2024
Authors: Putri Elsi Indah , Simanjuntak James P , Tampubolon Vina Novianty
Published: January 2025

Background: Stunting, defined as a condition where a child's height is significantly below the average for their age due to chronic malnutrition or recurring infections, remains a critical public health issue in Indonesia. This condition can lead to long-term cognitive and physical development challenges. This study explores the relationship between hemoglobin levels and leukocyte counts with stunting in the working area of Puskesmas Tanjung Agung, Muara Enim, in 2024.
Method: This study was conducted an observational analytic study with a cross-sectional design. Data on hemoglobin levels, leukocyte counts, and stunting incidence were collected from a sample of 79 children aged 24-60 months. Statistical analysis used the chi-square test to determine significant associations between variables.
Result: The study found that 64% of children with low hemoglobin levels and 66% of those with high leukocyte counts experienced stunting. The chi-square test indicated significant associations between low hemoglobin levels (p=0.003) and high leukocyte counts (p=0.001) with stunting.
Conclusion: The findings suggest a strong relationship between low hemoglobin levels, high leukocyte counts, and stunting incidence. These results highlight the need for integrated nutrition and health interventions to reduce stunting in rural areas.
Molecular and morphological characterisation of a new record of Bursaphelenchus arthuri (Nematoda: Aphelenchoididae) from a new host, Pinus pinea, in Europe
Authors: SILVA Hugo , CARDOSO Joana M.S. , DA COSTA Ricardo M.F. , ABRANTES Isabel , FONSECA Luís
Published: January 2025

Nematodes with morphological characters of Bursaphelenchus arthuri, a species of the Fungivorus group, first described in 2005 in China from imported coniferous packaging wood, were extracted from a centennial Pinus pinea tree with wilting symptoms in Coimbra, Portugal. Nematodes were transferred to Botrytis cinerea cultures to establish a nematode isolate which was characterised using morphological, morphometrical and molecular methods. Restriction fragment length polymorphism (RFLP) analysis carried out with five endonucleases of amplified internal transcribed spacer (ITS) of the rDNA region, revealed the characteristic restriction pattern described for Bursaphelenchus arthuri. Sequencing of the D2-D3 expansion region of the large subunit (LSU) of rDNA confirmed this identification. Phylogenetic analysis based on multiple sequence alignment of selected D2-D3 sequences showed that the Portuguese B. arthuri isolate formed a separate group, along with the other B. arthuri isolate from Taiwan available in GenBank, from those of other isolates of closely related nematodes species belonging to the Fungivorus group. This study is the first report of B. arthuri in Europe and from P. pinea.
Bibliometric and sequence analyses of the pathogenic Helicotylenchus nematodes
Authors: VOVLAS Alessio , AJOBIEWE Ebunoluwa Ijeoma , FANELLI Elena , TROCCOLI Alberto , DE LUCA Francesca
Published: January 2025

Publications between 2000 and 2024 on plant pathogenic species of Helicotylenchus nematodes were reviewed using bibliometric analyses with VOSviewer software. Sequences in GenBank for the same period were used to reconstruct phylogenetic relationships and correctly assign all the Helicotylenchus sequences in the database. The Scopus database was selected for its professional standards, international visibility, broad coverage, and controlled-vocabulary thesaurus available for indexing and retrieving documents. GenBank collects nucleotide sequences and relevant bibliographic and biological annotations for sequence analyses. This study highlighted research trends and specific complexities of working with Helicotylenchus, and the suitability of molecular markers used for identification of the main pathogenic species and confirmation of occurrence of species complexes or cryptic species.
Correlation of Raised Serum CA-125 Level with Laparotomy and Histopathology Findings of Ovarian Tumour in Combined Military Hospital, CMH Dhaka, Bangladesh
Authors: Akter Tasmia , Minkin Tanmina , Akter Sumaiya , Zahan Nusrat , Hossain Syeda Najiba , Bushra Anika , Dina Umme Salma , Khanam Afroja
Published: January 2025

Background: Ovarian tumour preferably malignant one is the leading cause of morbidity and mortality of women. Despite of advancement in surgical and chemotherapeutic treatment during the last decade, still survival rates are poor mainly due to late and incidental diagnosis. Objective: To find out correlation of raised serum CA -125 level with laparotomy and histopathological findings of ovarian tumours. Methodology: This observational descriptive study was conducted in the department of Obstetrics & Gynaecology in Combined Military Hospital, CMH Dhaka from January 2023 to December 2023 and data collection period of 6 months. Total 30 patients having ovarian tumour diagnosed clinically, by ultrasonography and with raised serum CA125 level were included in the study who underwent laparotomy and diagnosis confirmed by histopathology. Results: Total 30 cases of ovarian tumour with raised serum CA-125 were enrolled in the study. Patient presented with lump in the abdomen 26(86.7%) as the commonest presentation. The commonest tumour was epithelial tumour 22 (73.3%) followed by germ cell tumour 8(26.7%). Serous cyst adenoma (47.4%) was common benign tumour& serous cyst adenocarcinoma was the commonest malignant variety (36.3%). Serum CA-125 level was raised in all cases but highly raised in almost all the malignant ovarian tumour 10(90.9%), among them in poorly differntiated 2(18.2%) cases CA-125 level is markdly raised average is 433.5U/ml, then in moderately differentiated cases CA-125 level is highly raised avgerage is 221.5U/ml. In undifferentiated variety average level of CA-125 is 272.5U/ml. In well differentiated case CA-125 level raised to 69U/ml. And on laparotomy, tumours with malignant features has high serum level of CA-125 (>100U/ml). Conclusion: As serum CA-125 is highly raised in most of malignant ovarian tumour, mainly of epithelial variety and moreover makdly raised in poorly differented ones as well as these tumours are found to have features of malignancy on laparotomy, so we can conclude that raised serum CA-125 is a useful tumour marker for early screening, and as well as it can be used as a marker for assumption of the nature and aggresiveness of ovarian malingnancies. Thus, serum level of CA-125 can be used as a tool for detection of ovarian malignancy at early stage, to reduce the morbidity and mortality of patients, as well as to improve the survivility also to reduce the disease burden of the patient with ovarian tumour.
Erythropoietin Resistance Index in Hemodialysis Patients: A Single Moroccan Center Experience
Authors: Yassir Zajjari , Hajar Laasli , Imane Aragon , Larios Ahlonso , Majdouline Errihani , Taoufiq Aatif , Driss El Kabbaj
Published: January 2025

Introduction: Anemia is a common disorder in dialysis patients. The use of high doses of erythropoiesis stimulating agents is associated with poor outcomes in this population. The aim of this study, was to describe the response of ESA treatment in hemodialysis patients and determine the factors that can influence this response. Materials and Methods: We compared the effectiveness of erythropoietin treatment using the erythropoietin resistance index (ERI). The patients were divided into two groups according to their ERI: group 1 with ERI>10 UI/kg/week/g/100 ml and group 2 ERI 10 UI/kg/week/g/100 ml. We evaluated the effects of the anthropometric, demographic, clinical, laboratory and dialytic factors on ERI. Results: We found that low BMI, low serum albumin, high C-reactive protein, high serum ferritin and high predialysis serum 2 microglobulin levels were associated with high ERI and a hyporesponsiveness to erythropoietin. A multivariate analysis was showed significant association between high ERI and low serum albumin (OR=0.56; p=0.02). Conclusion: This may provide new contribution into anemia management in Hemodialysis patients. However, more prospective studies with a larger sample population are needed to generalize our results.
Japanese Encephalitis Virus in Pakistan: An Update and Way Forward
Authors: Nisa Tayyab UN , Siddiqui Adeena , Khan Saifullah
Published: January 2025

Japanese encephalitis (JE) is the leading form of mosquito borne viral encephalitis in Asia, with about 100,000 annual cases in which children are more dominant. The causative agent of JE is Japanese encephalitis virus (JEV) which is transmitted by Culex mosquitoes particularly Culex Tritaeniorhynchus. Mostly JE infections in humans are asymptomatic while severe JEV infection occurred in only few cases characterized by high grade fever, headache, seizures and unusual behavior, lesion and paralysis. The specific treatment of JEV is not available so far but the supportive care is effective. Many antiviral drugs have been investigated, but none of these have shown to improve the effect of JE except minocycline. The objective of gathering information and performing review is to asses JEV emergence possibility in Pakistan and to define some mitigation measure. In this review, the current knowledge of the prevalence and the pathogenesis of the JEV have been summarized. Furthermore, the current scenario of JEV, challenges and possible way forward in Pakistan has been discussed.
Strategi Pengembangan Gua Batu Cermin Labuan Bajo Sebagai Daya Tarik Wisata Alam
Authors: Enny Mulyantari  , Sahlit Sugesti  , Rikardus Yardiputra
Published: January 2025

Mirror Stone Cave has a potential attraction that needs to be developed as a natural tourist destination, however there are several factors that are obstacles in developing the cave's attraction. Therefore, this research aims to determine the development strategy in Mirror Stone Cave in increasing the attractiveness of natural tourist destinations. The research method uses a qualitative descriptive approach. The sampling technique uses a sampling technique. Data collection is carried out by means of observation, interviews and documentation. Test the validity of the data using source and method triagulation techniques. The data obtained was analyzed using the SWOT analysis technique. The research results show that to increase attractiveness, managers need to utilize better support and cooperation with the government, surrounding communities and stakeholders. By collaborating, efforts to increase the attractiveness of Mirror Stone Cave in terms of nature conservation, promotion, infrastructure, increasing workforce, community training as well as attractions, accessibility and amenities can be optimized well.
Studi Analisis Kesiapan Desa Jelantik Kecamatan Jonggat Kabupaten Lombok Tengah menjadi Desa Wisata
Authors: Muhamad Alam Setiawan  , Muharis Muharis
Published: January 2025

The trend of traveling to rural areas emerged after the Covid-19 pandemic because tourists wanted tourism with a healthier nuance. Tourism Villages then massively come up to meet this tourism demand. Jelantik Village, located in Central Lombok Regency, West Nusa Tenggara Province, is one of the villages that is seen as highly potential village to develop into a tourist village due to its attractions. This study aims to determine the readiness of Jelantik Village to become a tourist village. The method used in this study is a qualitative descriptive method. There are three important elements that are the subject of study to see the readiness of Jelantik Village to become a tourist village, namely the readiness of the A3 elements (Attractions, Accessibility, and Amenities), community elements, and government elements. The result of the study shows that Jelantik Village can be considered to be the strong embryo of tourist village. The readiness of the A3 elements has almost been fully met. The elements of society and government are basically ready in their respective contexts. However, the lack of communication seems to be an obstacle to a proper collaboration between the two elements, the society and the government. There is a fact that the community and the government are waiting for each other in starting the collaboration process makes progress stagnant in efforts to develop tourist villages in Jelantik Village.
Memperkuat Daya Tarik Setu Babakan: Integrasi Strategi Pemasaran Untuk Meningkatkan Kunjungan Wisatawan
Authors: Anisatul Auliya  , Uggasena Ariya Saputra  , Muhammad Rifky  , Muhammad Faza Alghifari  , Muhammad Iqbal Wily Mahmud  , Fredy Yohannes Noriaga  , Laura Aurelia Tedjasukmana
Published: January 2025

This research aims to conduct a SWOT analysis and develop an integrated marketing strategy to enhance Setu Babakan's appeal as a Betawi cultural destination. The study uses a descriptive qualitative method with primary data from official Indonesian government releases and secondary data from various publications and the internet. The SWOT analysis reveals strengths in natural, educational, and cultural tourism, weaknesses in public understanding and supervision, opportunities to increase community income and attract tourists, and threats from competition with other destinations. Based on this analysis, an integrated marketing strategy is formulated, focusing on target audiences like families, culture enthusiasts, nature tourists, and educational visitors. This strategy involves developing attractive tourism products, setting affordable prices, improving accessibility, utilizing digital marketing through websites and social media platforms, fostering partnerships with local governments, private sectors, and communities, and enhancing service quality and infrastructure. The recommended marketing integration aims to boost Setu Babakan's appeal as a Betawi cultural destination and attract more tourists.
Soluble receptor for advanced glycation end products and soluble interleukin-4 receptor in plasma and exhaled breath condensate as potential markers of asthma severity in children
Authors: Tereshchenko S. Y. , Smolnikova M. V. , Gorbacheva N. N.
Published: January 2025

Introduction. Asthma in children is characterized by chronic inflammation of the lower airways. The verification of reliable pro-inflammatory biomarkers, particularly non-invasive ones, is crucial for the diagnosis and treat[1]ment of childhood asthma. Aim. To evaluate the levels of soluble receptors for advanced glycation end products (sRAGE) and soluble interleukin-4 receptor (sIL-4R) in blood plasma and exhaled breath condensate (EBC) as potential biomarkers of bronchial asthma severity in children. Materials and methods. The study enrolled 195 children aged 6-17 years: 104 children with asthma and 91 children without any history of atopic diseases at baseline or during examination. The diagnosis and severity assessment of asthma were determined according to the Global Initiative for Asthma guidelines (GINA, 2021). EBC samples were collected using RTube devices (Respiratory Research, USA). The levels of sRAGE and sIL-4R were measured using magnetic bead-based multiplex immunoassay (MAGPIX, Luminex, USA). Results. Among 169 analyzed EBC samples, sRAGE was not detected in any sample above the minimum detectable level (14 pg/mL). In contrast, sIL- 4R levels exceeding the minimum detectable level (3 pg/mL) were found in 166 samples (98%). Plasma sRAGE levels were significantly lower in children with asthma (197.7 pg/mL) compared to controls (229.0 pg/mL; p=0.017). Similarly, EBC sIL-4R concentrations were significantly lower in children with asthma (120.3 pg/mL) compared to the control group (165.4 pg/mL; p<0.001). A statistically significant correlation was observed between plasma sRAGE levels and asthma severity (p=0.013, Kruskal-Wallis test). Conclusion. The measurement of plasma sRAGE and EBC sIL-4R levels appears to be a promising approach in developing novel biomarkers for the diagnosis, severity assessment, and monitoring of bronchial asthma in children.
Impulse oscillometry in the assessment of lung function in children with chronic nonspecific lung diseases
Authors: Knizhnikova E. V. , Evseeva G. P. , Polubartseva V. V. , Pichugina S. V. , Anureev S. V. , Suprun S. V. , Lebed’ko O. A.
Published: January 2025

Introduction. The article proposes an approach to evaluating the main parameters of impulse oscillometry (IOS) in children with chronic nonspecific lung diseases (CNSLD) using multivariate statistical methods. Aim. To identify types of ventilatory disorders in children with CNSLD using cluster analysis based on impulse oscillometry data. Materials and methods. A total of 71 children were examined, including 10 conditionally healthy children and 61 patients with CNSLD. Lung function was evaluated using IOS. The analyzed parameters included: Z5Hz—total respiratory impedance at an oscillation frequency of 5 Hz; R5Hz—total resistance at 5 Hz; R20Hz—proximal airway resistance at 20 Hz; X5Hz—reactance at 5 Hz; frequency dependence of resistance—D(Rrs5–Rrs20); delta Xrs5; and resonance frequency (Fres). Results. Analysis of the IOS data allowed all subjects to be divided into three clusters. The first cluster included children with the highest values of the main parameters studied. The clinical course of the disease in this group was characterized by pronounced clinical symptoms. Median values of the main respiratory impedance parameters in children of the second cluster remained within normal ranges; however, 20% of the children in this group showed increased values of X5Hz, D(Rrs5–Rrs20), delta Xrs5, and Fres with slightly elevated or normal R20Hz and R5Hz values, indicating ventilatory disorders at the level of the distal airways. The health status of children in the third cluster was more favorable compared to patients in the first and second clusters, and their IOS parameters were 1.5–2 times lower than those of children in the first and second clusters, indicating the absence of airway dysfunction. Conclusion. The presented IOS parameters will enable the practicing physician to make informed decisions regarding individual patients for better assessment of disease progression and treatment efficacy.
Effect of TAS2R20 gene polymorphisms on the development of asthma and the course of the disease
Authors: Naumov D. E. , Gassan D. A. , Kotova O. O. , Sheludko E. G. , Afanas’eva E. Yu. , Konev A. V. , Perelman J. M.
Published: January 2025

Introduction. It is known that bitter taste receptors (TAS2R) are localized in many organs and tissues including the respiratory tract. The functional characteristics of some TAS2R indicate their significant impact on the activity of mucociliary transport, cytokine production, and smooth muscle tone. Thus, TAS2R are often considered as promising targets for the therapy of asthma. Aim. To determine the effect of TAS2R20 polymorphisms on the development of asthma and the characteristics of the disease course. Materials and methods. The study included 230 patients with asthma of varying severity and 208 relatively healthy volunteers. Asthma control was determined using the Asthma Control Questionnaire and lung function were measured by spirometry. Single nucleotide polymorphisms (SNPs) TAS2R20 rs79420812, rs10845281, and rs61912291 were genotyped by PCR with melting analysis of oligonucleotide probes or amplification products. Total immunoglobulin E (IgE) levels in serum were determined using enzyme immunoassay. Results. Carriage of the TT genotype for rs61912291 was associated with uncontrolled asthma after adjustment for gender, age, and smoking status (OR 2.6, 95%CI (1.30-5.07), p=0.007). The same genotype was associated with signs of bronchial obstruction: a decrease in FEV1 to less than 80% (OR 5.42, 95%CI (1.48-19.87), p=0.01) and FEV1 /FVC to less than 70% (OR 2.44, 95%CI (1.43-4.18), p=0.001) after adjustment for gender, age, and smoking status. In addition, the homozygous state for the T allele for rs61912291 SNP was more common in asthma patients with IgE level of more than 100 IU/ml (OR 2.6 95%CI (1.22-5.54), p=0.01 after adjustment for gender, age and smoking status). Conclusion. SNPs of TAS2R20 do not affect the development of asthma but may be associated with the features of the disease course. Carriage of the TT genotype for rs61912291 SNP adversely affects the control of asthma, airway patency and is accompanied by an increased IgE level.
X-ray-functional diagnostics of small and large airways damage in patients with community-acquired pneumonia
Authors: Il’in A. V. , Ignat’eva E. A. , Bezrukov N. S. , Perelman Yu. M.
Published: January 2025

Aim: To assess the densitometric parameters of lung tissue indicative of small airway involvement and the morphometric parameters of large bronchi in patients with community-acquired pneumonia before and after treatment, and to analyze their diagnostic and clinical significance in comparison with spirometric parameters. Materials and methods. The authors analyzed CT and spirography data of 44 patients with community-acquired pneumonia before and after treatment with an interval of 10-14 days between the studies. Patients were divided into 2 groups according to the change in airflow according to the primary CT data. Lung function was assessed by forced expiratory flow spirometry. All examined patients underwent CT of lungs in the inspiratory phase with measurement of volumes in 3 density ranges, morphometric indices of large bronchi. Results. After the course of anti-inflammatory therapy there was a recovery of lung inflation in both groups. It was found that inflation was disturbed in both lungs, regardless of the localization of changes (unilateral, bilateral), which is associated with bronchial lesions. In the group with decreased inflation there was a positive correlation between the internal diameter of B10 of the right lung and forced expiratory volume in 1 sec (FEV1 ) (r=0,51, p<0,0001), negative correlation - between the thickness of B10 wall of the right lung and FEV1 (r=-0,53, p<0,0001). In the group of patients with lung hyperinflation, positive correlations were found between B10 inner diameter and FEV1 (r=0,46, p=0,0001), between the index of inspiratory inflation and FEV1 (r=0,80, p<0,0001). Conclusion. X-ray functional assessment of ventilation disorders by high-resolution CT with postprocessing allows to determine the type and reversibility of lung ventilation dysfunction and thereby significantly complement the visual characterization of lung lesions in community-acquired pneumonia.
Vaccination against pneumococcal infection as a tool to reduce mortality in patients with COPD and IHD
Authors: Ignatova G. L. , Avdeev S. N. , Antonov V. N. , Blinova E. V. , Osikov M. V.
Published: January 2025

Introduction. Ischemic heart disease (IHD) and chronic obstructive pulmonary disease (COPD) are currently major contributors to morbidity and mortality in the Russian Federation and worldwide. Preventive programs that include the use of pneumococcal vaccines, primarily the 13-valent pneumococcal conjugate vaccine, are widely recognized tools in managing patients with comorbid conditions. Aim. To assess the clinical efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13) in patients with COPD and IHD over a 10-year follow-up period. Materials and methods. The study included a total of 500 male patients diagnosed with COPD and IHD who received treatment or were under observation at the Pulmonology Center in Chelyabinsk. Patients were divided into three groups. The first group consisted of 149 vaccinated patients with isolated COPD (without IHD); the second group included 175 vaccinated patients with both COPD and IHD; the third group comprised 176 unvaccinated patients with COPD. The 13-valent pneumococcal conjugate vaccine (Prevnar 13) was used. The primary endpoint over the 10-year follow-up was the number of developed pneumonias. Secondary endpoints included the number of exacerbations, hospitalizations, and all-cause mortality. Results and conclusions. Vaccination with PCV13 significantly improved patient survival over at least a 10-year observation period. The use of the conjugate pneumococcal vaccine led to a significant reduction in the incidence of community-acquired pneumonia in patients with COPD, as well as in those with combined COPD and IHD. Vaccination resulted in the stabilization of key clinical and functional parameters, even over a 10-year period. Including pneumococcal vaccines in clinical guidelines for patients with comorbid COPD and IHD should be mandatory and prioritized.
THE ROLE OF GENETIC AND ENVIRONMENTAL FACTORS IN THE DEVELOPMENT OF HUMAN OBESITY
Authors: Pinki Gautam  , Dr. Sadhana Yadav  , Miss. Vaishnavi Tripathi  , Dr. Pratibha Yadav
Published: January 2025

Obesity is a multifactorial condition with significant health implications, including increased risks for type 2 diabetes, cardiovascular diseases, and various cancers. Understanding its development requires examining both genetic predispositions and environmental influences. The present paper makes an attempt to explore the genetic and environmental factors and their interactions in obesity, with a particular focus on recent studies from India. By integrating findings from global and Indian researches, this paper aims to provide a comprehensive view of obesity's complex etiology and offer insights for future research and public health strategies.
KEYWORDS: Obesity, Genetic Factors, Environmental Impacts, type 2 diabetes.
INTERESSE DOS GRADUANDOS DA EDUCAÇÃO A DISTÂNCIA PELA INICIAÇÃO CIENTÍFICA
Authors: De Menezes Rosilda , Araújo Edmyr Ferreira Costa , Barbosa Dayane de Oliveira , Araujo Vanessa Gonçalves Vieira , Dias Fátima Aparecida da Silva , Figueiredo Helenara Regina Sampaio
Published: January 2025

Este estudo investigou o interesse e as percepções de graduandos das modalidades Educação a Distância (EaD) e semipresencial em relação à Iniciação Científica (IC). Os dados foram coletados por orientandos do Programa de Iniciação Científica e Tecnológica a Distância (PICT-EAD) por meio de questionários online, direcionados aos graduandos dos cursos de Tecnólogo, Bacharelado, Licenciatura e 2ª Licenciatura, nas modalidades EaD e semipresencial da própria Instituição de Ensino Superior (IES). Os resultados mostraram interesse dos graduandos na IC e na continuação da pesquisa em pós-graduação. No entanto, revelaram baixa participação em práticas e eventos científicos, além de desconhecimento sobre o programa de IC que a IES proponente oferta para os graduandos das modalidades EaD e semipresencial. Destacaram-se as contribuições do PICT-EAD para a prática profissional e Letramento Científico (LC) dos participantes, enfatizando a necessidade de ampliação das oportunidades de pesquisa para os graduandos de cursos à distância.
Duelo en pandemia. Análisis funcional del duelo complicado.
Authors: Azurdia Turcios Juan José
Published: January 2025

Además de la pérdida de salud y empleo, la muerte de seres queridos fue una de las características más significativas de la vida durante el confinamiento por la pandemia del COVID-19. Este estudio tuvo como propósito sistematizar testimonios de dolientes que perdieron a un familiar a causa del virus. En el marco del enfoque cualitativo y el diseño secuencial, se entrevistó a 5 voluntarios que se encontraron en duelo complicado por la muerte de un familiar a causa del COVID-19. Como resultado, se identificó que las medidas de distanciamiento social hicieron vivir el duelo en soledad física y también en soledad subjetiva, que fue una creencia presente en los consultantes con duelo complicado. En contraposición, las creencias que favorecieron la elaboración del duelo se relacionaron con la religión. Las conductas que movilizaron al doliente hacia la resolución del duelo fueron la meditación, el ejercicio y la socialización con amigos. Se concluye que la soledad percibida y el autorreproche son factores presentes en el duelo complicado.
THE USE OF BLOCKCHAIN TECHNOLOGY IN THE INTERNAL CONTROL OF ENTERPRISE PROCUREMENT MANAGEMENT
Authors:   Moscow Technical University of Communications and Informatics, Dzhabrailov Khizar A. , Taramov Alu A. ,   Grozny State Petroleum Technical University named after Academician M. D. Millionshchikov, Grigorieva Irina V. ,   Kazan State Energy University
Published: January 2025

Being the starting point of the production and operational activities of the enterprise, procurement costs and risks have a very important impact on the production and operational activities of the enterprise. Thus, strengthening internal control over the procurement management of the enterprise is important for the production and operation of the enterprise. Currently, the implementation of internal procurement management control of an enterprise, provided that it is carried out at key points and links in procurement risk management, can effectively reduce the risks of enterprise procurement management to a certain extent. Based on the current situation with internal control of procurement management, this article analyzes the shortcomings of existing internal control, and combines the relationship between blockchain technology and internal control of procurement management to give specific application ideas.
INVESTMENT ACTIVITIES OF ENTERPRISES: FEATURES AND PROBLEMS AT THE PRESENT STAGE
Authors:   Grozny State Petroleum Technical University named after Academician M. D. Millionshchikov, Akhmieva Gulzhana R. , Dzhabrailova Selima S.-Kh. ,   Grozny State Petroleum Technical University named after Academician M. D. Millionshchikov
Published: January 2025

The article considers the peculiarities and problems of investment activity of modern enterprises. According to the authors, investment decisions should be justified taking into account the results of evaluation and comparison of the volume of proposed investments with the amount of possible investment profit. The authors believe that the insufficient volume of investment at modern enterprises is due to the existence of obstacles of both financial and non-financial (economic) nature. At that, as the main financial obstacles they consider: insufficiency of own funds at enterprises; difficulties in attracting debt financing; use of available funds for other types of activities, which provide higher profitability for a shorter period. The main non-financial obstacle, according to the authors, is the high degree of uncertainty about future economic conditions, which may have a negative impact on the level of return on investment.
PERSONAL FREEDOM AS AN OBJECT OF CRIMINAL– LEGAL PROTECTION IN THE RUSSIAN FEDERATION
Authors:   Chechen State University named after A. A. Kadyrov, Maltsagov Isa D. , Simorin Alexey I. ,   Don State Technical University, Isipova Lalita R. ,   Chechen State Pedagogical University
Published: January 2025

The article is devoted to the study of personal freedom as an object of criminal legal protection in the Russian Federation. The aim of the study is to analyze the existing norms of criminal law protecting personal freedom, to identify gaps and problems of their application in practice, as well as to formulate proposals to improve the legislation. Within the framework of the goal set, the following tasks were solved: study of constitutional guarantees of personal freedom; analysis of the elements of crimes that infringe on personal freedom; study of judicial practice in cases of crimes against personal freedom; identification of problems of law enforcement and development of proposals for their solution. The results of the study have shown the need to clarify certain corpus delicti of crimes and to improve the effectiveness of law enforcement agencies in the investigation and prevention of crimes against personal freedom. The practical significance of the work lies in the possibility of using the findings and proposals to improve the legislation and increase the effectiveness of law enforcement.
TRAINING NEURAL NETWORKS FOR RECOGNITION OF ANOMALIES IN CHROMATOGRAPHIC ANALYSIS DATA OF NATURAL GAS
Authors:   Federal State Budgetary Educational Institution of Higher Education “Chechen State University” them. A. A. Kadyrov”, Grozny, Russian Federation, Shakhbazova Madina S. , Zaitov Ruslan I. ,   Kazan State Power Engineering University, Kazan, Russian Federation, Dzhatdoeva Diana T. ,   North Caucasian State Academy, Cherkessk, Russian Federation
Published: January 2025

The article discusses the use of neural network models for recognizing anomalies in chromatographic analysis data of natural gas. Chromatographic analysis is an important tool for quality control and monitoring of gas mixture composition, but traditional anomaly detection methods such as thresholding and principal component analysis (PCA) often fail to cope with high-dimensional and noisy data. The paper presents the results of applying various neural network architectures, including autoencoders, convolutional networks (CNNs), and recurrent networks with LSTM mechanisms, to analyze chromatography data. Particular attention is paid to the interpretation of the detected anomalies and their relationship with the processes of technological equipment. The results of the study confirm the effectiveness of neural network models in the tasks of automation and improving the reliability of chromatographic analysis of natural gas.
ANALYSIS OF PARAMETERS OF VACANCIES IN REGIONS WITH HIGH DEMAND FOR ENGINEERING SPECIALTIES
Authors:   Kazan National Research Technological University, Garafiev Ilshat Z. , Garafieva Gulshat I. ,   Kazan National Research Technological University
Published: January 2025

The study identifies salary growth trends and analyzes the impact of various factors, such as industry, company size, type of employment, and work schedule, on the level of salaries offered. Particular attention is paid to the distribution of average and median values of maximum and minimum salaries. The results of the study emphasize the importance of work experience and industry specificity in determining the level of salary.
APPROACH TO THE FORMATION OF THE DIGITAL ECOSYSTEM OF STATE CORPORATIONS
Authors:   Saint Petersburg State Marine Technical University, Saint Petersburg, Russia, Perfiliev Ilya V. , Balashova Elena S. ,   Saint Petersburg State Marine Technical University, Saint Petersburg, Russia
Published: January 2025

The article examines instrumental and methodological procedures for assessing the competitiveness of economic entities of the high-tech industrial complex of Russia; interprets the main directions of increasing the competitiveness of enterprises by improving the education management system and improving the quality of human resources of enterprises; examines an extensive list of theoretical, methodological and practical-applied management problems in the context of the triad "education - science – production"; critically The causal mechanisms that have a destructive and destructive effect on the competitiveness of enterprises are rethought, on the basis of which methods of stimulating it are proposed, implemented in the context of an intra-company strategy for education management and human resource quality.
METHODS OF RISK ASSESSMENT IN THE FIELD OF TECHNOSPHERE SAFETY
Authors:   GGNTU named after academician M. D. Millionshchikov, Erzhapova Raisa S. , Bokova Elmira S. ,   GGNTU named after academician M. D. Millionshchikov
Published: January 2025

The article deals with the methods of risk assessment in the field of technosphere safety aimed at minimizing potential threats to people and the environment arising in the process of operation of technical systems. The aim of the study is to systematize the existing approaches to risk assessment, identify their advantages and disadvantages, and offer recommendations for improving the techniques. The tasks include analyzing quantitative and qualitative assessment methods, investigating factors affecting the level of risks, and reviewing practical examples of their application. As a result, an integrated approach to risk assessment has been developed that combines elements of various methodologies. The scientific novelty of the study lies in the integration of theoretical and practical aspects of risk assessment, which allows increasing the predictability and viability of technosphere systems.
DIGITAL ASPECTS OF HR MANAGEMENT
Authors:   Samara State Technical University, Samara, Russia, Malina Aliya B. , Ryadnov Egor R. ,   Samara State Technical University, Samara, Russia, Novoselova Olga V. ,   Samara National Research University, Samara, Russia
Published: January 2025

Currently, companies are striving to increase the efficiency of human resource management and reduce the time costs associated with manual processing and transfer of data between departments. Automation of these processes allows not only to optimize employee work-ing time, but also to significantly reduce the likelihood of errors, improve the protection of per-sonal data and increase the overall productivity of organizational processes.
The scientific article presents a technical solution in this area. The introduction of an internal module for automating the process of registering employees for employment will increase the efficiency of the company's HR management. The introduction of a single automation software module simplifies and speeds up the exchange of information, ensuring transparency and consistency of actions of all participants in the process.
Application of supervised and semi-supervised learning prediction models to predict progression to cirrhosis in chronic hepatitis C
Authors: Hu Yueying , Tang Weijing , Beste Lauren A. , Su Grace L. , Ioannou George N. , Van Tony , Zhu Ji , Waljee Akbar K.
Published: January 2025

In this study, we aim to examine the efficacy of deep learning methods in predicting the 1-year risk of developing cirrhosis in patients with chronic hepatitis C (CHC), as defined by transient elastography (TE), in comparison with conventional models, as well as to assess whether semi-supervised learning can improve performance relative to supervised learning when the labels are limited. We used the electronic health records of the 169,317 valid patients in the Veterans Health Administration system from 2000 to 2016. Predictor variables contained baseline characteristics, such as age, gender, race, hepatitis C virus genotype, and 26 liver-related longitudinal variables such as sustained virologic response and laboratory data. The response variable, developing cirrhosis, is defined as liver stiffness >12.5 kPa on TE within a 1-year window. Using baseline and longitudinal variables, we fitted four prediction models, including logistic regression (LR), random forest (RF), supervised recurrent neural network (RNN), and semi-supervised RNN (semi-RNN) and evaluated their performances. Both RNN (area under the receiver operating characteristic curve [AuROC] 0.744) and semi-RNN (AuROC 0.785) accurately predicted the risk of cirrhosis within 1 year and significantly outperformed RF (AuROC 0.731) and LR (AuROC 0.724). By enabling early identification of high-risk patients, these models hold promise for targeted interventions in clinical CHC treatment.
Opioid use among Nigerian students: Exploring knowledge gaps and preventive strategies
Authors: Adeyemi Adegoke Abdullahi , Tariq Maryam , Muhammad Syed , Olatunde Oduoye Malik , Imam Maryam , Faith Olanrewaju Omotayo , Adole Inalegwu John , Motunrayo Ojebola Abisola , Chinonso Ubechu Samuel
Published: January 2025

The increasing rate of opioid consumption among Nigerian students is alarming. Despite the therapeutic benefits of opioids, their excessive use could be detrimental. Exploring knowledge gaps and implementing preventive strategies are necessary to curb opioid misuse among Nigerian students. This review aimed to identify the prevalence estimates of non-prescribed opioid use among Nigerian students and explore the cultural and societal factors favoring opioid and other drug use in this population. It further aimed to provide and discuss strategies that could offer effective and long-lasting solutions for Nigerian policymakers to curb opioid use among Nigerian students. A systematic search strategy identified relevant studies from databases such as PubMed and Google Scholar using keywords such as opioid misuse, students, Nigeria, prevention strategies, and opioid use disorder. Articles on the prevalence rates, associated factors, and preventive measures were extracted. The findings revealed a high prevalence of opioid use among Nigerian students, particularly in the southwestern (7.87%) and northeastern (6.57%) parts of Nigeria. Approximately 4.6 million Nigerians, constituting 4.7% of the population, have used opioids for non-medical purposes. Tramadol and codeine are the most commonly misused opioids. Cultural practices and belief systems often impact the knowledge, attitudes, and perceptions of opioid use among students. Efforts to prevent and control opioid misuse in Nigeria should focus on effective coordination among students. Health-promotion measures and specific protection should be promoted alongside early diagnosis, prompt treatment, and rehabilitation of affected individuals.
Repurposing anabolic agents in cancer cachexia: A perspective
Authors: Lambert Charles Paul
Published: January 2025

Cancer cachexia kills millions of people worldwide every decade. Attenuating or mitigating this muscle-wasting condition associated with cancer could significantly reduce cancer-related deaths. The drug development pipeline takes 10 – 15 years to complete in the United States. During this period, hundreds of thousands to millions worldwide die of cancer cachexia. Medicines already approved by the United States Food and Drug Administration that cause significant muscle mass gains in healthy individuals could be used “off-label” or “repurposed” in individuals who do not have androgen receptor-responsive cancers. These agents are testosterone and anabolic steroids. In individuals with androgen receptor-responsive tumors, repurposing anabolic agents (e.g., beta-2 adrenergic agonist albuterol), which increases muscle mass through different mechanisms than the androgen receptor, is warranted. New research suggests that phenotyping for the androgen receptor must be conducted individually, even for the same cancer. The utilization of these two types of anabolic agents – those that use the androgen receptor and those that do not – in appropriate clinical trials in cancer cachexia is also warranted.
Multicavity structures with triply periodic minimal surface for broadband and perfect sound absorption manufactured by laser powder bed fusion
Authors: Zhang Mingkang , Deng Mingjian , Wang Guanhao , Yin Sihua , Liu Wenbin , Liu Chang , Chen Jie
Published: January 2025

This research proposes a multicavity and a graded structure design method for triply periodic minimal surface (TPMS) structures with broadband and perfect sound absorption. TPMS structures were manufactured by laser powder bed fusion. The sound absorption coefficient curves and acoustic band structure of TPMS are analyzed using a two-microphone impedance tube. As the thickness of TPMS structures increases, the noise reduction coefficient of TPMS structures increases linearly, and the first resonance frequency shifts to the lower frequency. The acoustic band structures indicate that the acoustic bandgap of TPMS structures shifts to a lower frequency with increasing thickness. Diamond has the highest noise reduction coefficient among these four types of TPMS. The TPMS with a multicavity design has multiple resonance peaks. Notably, the five resonance peaks of the multicavity-I-Wrapped Package (IWP) are all above 0.94, achieving near-perfect sound absorption over a wide frequency range. The semi-absorption bandwidth of the multicavity-TPMS structure has been widened, except for multicavity-diamond structures. Both uniform and multicavity TPMS present a subwavelength absorption peak. The graded design method can broaden the semi-absorption bandwidth of TPMS, and the combination of graded and multicavity designs can further enhance broadband and achieve perfect sound absorption.
Innovation and firm performance: Evidence from malaysian SMEs
Authors: Gill Daljeet Singh , Hanafi Norshafizah
Published: January 2025

The study is designed to examine and analyze the effects of product innovation and process innovation on firm performance of Small Medium Enterprises (SMEs) within the service industry in Malaysia. The populations of the respondents are owner managers of 150 SME firms, constituting 18% response rate. To test the relationship of the variables, Partial Least Squares Structural Equation Modeling (PLS-SEM) is utilized. Results of the analysis indicate that, product and process innovation positively impact as much as, 43% on overall firm’s performance. SME firms’ that emphasizes product and process innovation are proven to improve the performance. The study highlights that innovation is important aspect in all entrepreneurial activities that further ensure improved firm performance.
An Analytical and Numerical Approach to Solve the Tsunami Wave Propagation Equation
Authors: Kesarwani Juhi , Majumder Abhijit , Sharma Ishita , Kesarwany Ashish Kumar
Published: January 2025

We study the mathematical model of tsunami wave propagation (TWP) along the coastline of an ocean. The described model is represented by a system of non-linear partial differential equations. In this study, we employ two different techniques: one is the Adomian decomposition method (ADM, which is an analytical approach), and another is the finite difference method (FDM, which is a numerical approach) to obtain the solution for the proposed TWP model successfully. The solutions gained are numerically represented in graphs and tables. The validity of the solutions is investigated by comparing this proposed method with the fractional reduced differential transform method (FRDTM). The novelty of this paper is that we have demonstrated that the numerical method (FDM) better approximates the solution of our partial differential equation than the analytical method (ADM), and this has not been explored before in any other works. We examine the velocity and height of the coastline of an ocean from the tsunami wave equation using numerical and analytical techniques. MATLAB and MAPLE are used to obtain numerical and graphical representations.
Spatio-Temporal Analysis and Prediction by Logistic Regression of Respiratory Diseases in India
Authors: Subramani Priyanka , Dhakshnamoorthy Kalpanapriya
Published: January 2025

Respiratory illnesses rank among the top causes of death and disability in India, influenced by factors such as limited healthcare access, air pollution, smoking, allergens, and a lack of awareness. Despite government efforts to improve respiratory health policies, increase awareness, enhance healthcare facilities, and promote preventive measures, the incidence of respiratory diseases has been on the rise in recent years. This study uses Geographic Information System (GIS) technology to analyze the spatial and temporal distribution patterns of respiratory diseases, aiming to improve our understanding of the contributing factors. Principal component extraction and spatial statistical analyses were utilized to identify the main respiratory illnesses and their geographical distribution. The study concentrated on three major respiratory diseases Tuberculosis, Pneumonia, and Acute Respiratory Distress Syndrome (ARDS) which are related to each other diseases. The findings shows significant variations in the geographical distribution of these diseases across the time period 2019-2021. This spatio-temporal data is essential for enhancing current prevention, control, and treatment strategies for respiratory illnesses in the study area. The methodology applied in this study can be adapted to other regions with similar geographical characteristics and patient data. The study investigated the association of 14 variables with respiratory illnesses. The results indicate that certain variables are associated with an increased risk of frequent flare-ups and hospital admissions due to respiratory diseases. Furthermore, the severity of flare-ups leading to hospital admissions is significantly linked to the presence of comorbidities. These critical and easily measurable variables provide valuable insights for the optimal management of ambulatory patients with respiratory diseases.