bluuebunny/crossref_metadata_2025 huggingface dataset:
Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome
Authors: Shan Zack Y. , Kwiatek Richard , Burnet Richard , Del Fante Peter , Staines Donald R. , Marshall‐Gradisnik Sonya M. , Barnden Leighton R.
Published: June 2017

Unrefreshing sleep is a hallmark of chronic fatigue syndrome/myalgic encephalomyelitis (CFS). This study examined brain structure variations associated with sleep quality in patients with CFS. 38 patients with CFS (34.8 ± 10.1 years old) and 14 normal controls (NCs) (34.7 ± 8.4 years old) were recruited. All subjects completed the Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index (PSQI), and Chalder Fatigue Scale (CFQ) questionnaires. Brain MRI measures included global and regional grey and white matter volumes, magnetization transfer T1 weighted (MT‐T1w) intensities, and T1 weighted (T1w) and T2 weighted spin echo signal intensities. We performed voxel based group comparisons of these regional brain MRI measures and regressions of these measures with the PSQI and CFQ scales adjusted for age, anxiety and depression, and the appropriate global measure. In CFS patients, negative correlations were observed in the medial prefrontal cortex (mPFC) between PSQI and MT‐T1w intensities (family‐wise error corrected cluster, PFWE < 0.05) and between PSQI and T1w intensities (PFWE < 0.05). In the same mPFC location, both MT and T1w intensities were lower in CFS patients compared with NCs (uncorrected voxel P < 0.001). This study is the first to report that brain structural differences are associated with unrefreshing sleep in CFS. This result refutes the suggestion that unrefreshing sleep is a misperception in CFS patients and further investigation of this symptom is warranted.
Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice
Authors: Soares Ana Francisca , Paz‐Montoya Jonathan , Lei Hongxia , Moniatte Marc , Gruetter Rolf
Published: June 2017

Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age‐ and sex‐dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but has been insufficiently characterized under standard housing conditions, where age‐related metabolic alterations are known to occur. We studied a total of 10 male and 10 female mice longitudinally. At 3, 7 and 11 months of age, non‐invasive 1H‐magnetic resonance spectroscopy (1H‐MRS) was used to monitor hepatic lipid content (HLC) and fatty acid composition in vivo, and glucose homeostasis was assessed with glucose and insulin challenges. At the end of the study, hepatic lipids were comprehensively characterized by nuclear magnetic resonance (NMR) and liquid chromatography‐mass spectrometric analyses of liver tissue samples. In males, HLC increased from 1.4 ± 0.1% at 3 months to 2.9 ± 0.3% at 7 months (p < 0.01) and 2.7 ± 0.3% at 11 months (p < 0.05), in correlation with fasting insulin levels (p < 0.01, r = 0.51) and parameters from the insulin tolerance test (ITT; p < 0.001, r = –0.69 versus area under the curve; p < 0.01, r = –0.57 versus blood glucose drop at 1 h post‐ITT; p < 0.01, r = 0.55 versus blood glucose at 3 h post‐ITT). The metabolic performance of females remained the same throughout the study, and HLC was higher than that of males at 3 months (2.7 ± 0.2%, p < 0.01), but comparable at 7 months (2.2 ± 0.2%) and 11 months (2.2 ± 0.1%). Strong sexual dimorphism in bioactive lipid species, including diacylglycerols (higher in males, p < 0.0001), phosphatidylinositols (higher in females, p < 0.001) and omega‐3 polyunsaturated fatty acids (higher in females, p < 0.01), was found to be in good correlation with metabolic scores at 11 months. Therefore, in mice housed under standard conditions, sex‐specific composition of bioactive lipids is associated with metabolic protection in females, whose metabolic performance was independent of hepatic cytosolic lipid content.
A nonintrusive proper generalized decomposition scheme with application in biomechanics
Authors: Zou X. , Conti M. , Díez P. , Auricchio F.
Published: June 2017

Proper generalized decomposition (PGD) is often used for multiquery and fast‐response simulations. It is a powerful tool alleviating the curse of dimensionality affecting multiparametric partial differential equations. Most implementations of PGD are intrusive extensions based on in‐house developed FE solvers. In this work, we propose a nonintrusive PGD scheme using off‐the‐shelf FE codes (such as certified commercial software) as an external solver. The scheme is implemented and monitored by in‐house flow‐control codes. A typical implementation is provided with downloadable codes. Moreover, a novel parametric separation strategy for the PGD resolution is presented. The parametric space is split into two‐ or three‐dimensional subspaces, to allow PGD technique solving problems with constrained parametric spaces, achieving higher convergence ratio. Numerical examples are provided. In particular, a practical example in biomechanics is included, with potential application to patient‐specific simulation.
Cryptophycins: cytotoxic cyclodepsipeptides with potential for tumor targeting
Authors: Weiss Christine , Figueras Eduard , Borbely Adina N. , Sewald Norbert
Published: June 2017

Cryptophycins are a class of 16‐membered highly cytotoxic macrocyclic depsipeptides isolated from cyanobacteria. The biological activity is based on their ability to interact with tubulin. They interfere with microtubule dynamics and prevent microtubules from forming correct mitotic spindles, which causes cell‐cycle arrest and apoptosis. Their strong antiproliferative activities with 100‐fold to 1000‐fold potency compared with those of paclitaxel and vinblastine have been observed. Cryptophycins are highly promising drug candidates, as their biological activity is not negatively affected by P‐glycoprotein, a drug efflux system commonly found in multidrug‐resistant cancer cell lines and solid tumors. Cryptophycin‐52 had been investigated in phase II clinical trials but failed because of its high neurotoxicity. Recently, cryptophycin conjugates with peptides and antibodies have been developed for targeted delivery in tumor therapy. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.
Static pentane extraction as a potential alternative to Soxhlet extraction for polypropylene olive oil overall migration limit measurements
Authors: Ehlers Charles , Taylor Brenda
Published: June 2017

Static pentane extraction of olive oil from polypropylene was evaluated as a safer, higher throughput alternative to pentane Soxhlet extraction for the recovery of olive oil from polypropylene for overall migration limit determinations. Static, ambient temperature, pentane extraction achieved quantitative recovery of olive oil from polypropylene plaques prepared by using the OM‐5 overall migration limit protocol. In addition to validation data for static extractions, a modified esterification procedure is presented as a means to accommodate the larger sample sets that are enabled with static extraction.
Motion control skill assessment based on kinematic analysis of robotic end‐effector movements
Authors: Liang Ke , Xing Yuan , Li Jianmin , Wang Shuxin , Li Aimin , Li Jinhua
Published: June 2017

Background

The performance of robotic end‐effector movements can reflect the user's operation skill difference in robot‐assisted minimally invasive surgery. This study quantified the trade‐off of speed–accuracy–stability by kinematic analysis of robotic end‐effector movements to assess the motion control skill of users with different levels of experience.

Methods

Using ‘MicroHand S’ system, 10 experts, 10 residents and 10 novices performed single‐hand test and bimanual coordination test. Eight metrics based on the movements of robotic end‐effectors were applied to evaluate the users' performance.

Results

In the single‐hand test, experts outperformed other groups except for movement speed; in the bimanual coordination test, experts also performed better except for movement time and movement speed. No statistically significant difference in performance was found between residents and novices.

Conclusions

The kinematic differences obtained from the movements of robotic end‐effectors can be applied to assess the motion control skill of users with different skill levels.
Manipulator‐driven selection of semi‐active MR‐visible markers
Authors: An Junmo , Webb Andrew G. , Shah Dipan J. , Chin Karen , Tsekos Nikolaos V.
Published: June 2017

Background

A method for the identification of semi‐active fiducial magnetic resonance (MR) markers is presented based on selectively optically tuning and detuning them.

Methods

Four inductively coupled solenoid coils with photoresistors were connected to light sources. A microcontroller timed the optical tuning/detuning of coils and image collection. The markers were tested on an MR manipulator linking the microcontroller to the manipulator control to visibly select the marker subset according to the actuated joint.

Results

In closed‐loop control, the average and maximum were 0.76° ± 0.41° and 1.18° errors for a rotational joint, and 0.87 mm ± 0.26 mm and 1.13 mm for the prismatic joint.

Conclusions

This technique is suitable for MR‐compatible actuated devices that use semi‐active MR‐compatible markers.
A decoupled designing approach for sampling consensus of multi‐agent systems
Authors: Liu Yongfang , Zhao Yu , Chen Guanrong
Published: June 2017

This paper introduces the motion‐planning approaches to solve the distributed consensus problems via sampling measurements. First, for first‐order multiagent systems, a class of sampled‐data–based algorithms are developed with arbitrary sampling periods, which solve the asymptotic consensus problem under both directed fixed and random switching topologies. Then, a new kind of distributed consensus algorithms is designed based on sampling measurements for second‐order multiagent systems. Under both the directed fixed and periodical switching topologies, asymptotic consensus problems of second‐order multiagent systems can be solved by using the proposed algorithms. Compared with existing continuous‐time consensus algorithms, one of remarkable advantages of proposed algorithms is that the sampling periods, communication topologies, and control gains are decoupled and can be separately designed, which relaxes many restrictions in controller designs. Finally, some numerical examples are given to illustrate the effectiveness of the analytical results.
Assessing the impact of Volatile Functionality removal in web applications: Model‐Driven vs Code‐Based approaches
Authors: Urbieta M. , Frajberg D. , Rossi G.
Published: June 2017

Web applications must quickly adapt to new business demands to keep clients onboard. When unexpected and unforeseen requirements appear, the changes pose challenges to software engineers as they were not considered in the application design and such new functionality can be only valid only for a period in certain situations.

This work presents a comparison of maintenance consequences in the software quality when using a Model‐Driven approach against a Code‐Based one where changes are managed in an ad hoc way. We used the removal of volatile functionality as case of study due to the fact that its characteristics stress the development process. We considered both external and internal quality of deliverables.

For assessing the quality of deliverables, we evaluated the production of more than 35 students using both approaches considering their perception gathered through questionnaires and their deliverables.

We present the preliminary evidence that there is no significant difference between approaches. Model‐Driven performed slightly better than Code‐Based, but both responded negatively in terms of deliverables' quality. Results show that maintenance tasks are detrimental to software quality where Model‐Driven approach does not excel over Code‐Based approach. The Model‐Driven approach only highlighted on productivity.
Debugging‐workflow‐aware software reliability growth analysis
Authors: Cinque Marcello , Cotroneo Domenico , Pecchia Antonio , Pietrantuono Roberto , Russo Stefano
Published: June 2017

Software reliability growth models support the prediction/assessment of product quality, release time, and testing/debugging cost. Several software reliability growth model extensions take into account the bug correction process. However, their estimates may be significantly inaccurate when debugging fails to fully fit modelling assumptions. This paper proposes debugging‐workflow‐aware software reliability growth method (DWA‐SRGM), a method for reliability growth analysis leveraging the debugging data usually managed by companies in bug tracking systems. On the basis of a characterization of the debugging workflow within the software project under consideration (in terms of bug features and treatment phases), DWA‐SRGM pinpoints the factors impacting the estimates and to spot bottlenecks, thus supporting process improvement decisions. Two industrial case studies are presented, a customer relationship management system and an enterprise resource planning system, whose defects span a period of about 17 and 13 months, respectively. DWA‐SRGM revealed effective to obtain more realistic estimates and to capitalize on the awareness of critical factors for improving debugging.
Hematopoietic stem cell transplantation in qatar
Authors: Bakr Mohammad , Al-Hijji Ibrahim , Menasria Naziha , Merenkov Zeyd , Al-Azzawi Safaa , Taha Ruba , Gulied Amaal , Gillespie Catherine Anne , Dermime Said , Liakopoulou Effie , Knuth Alexander
Published: June 2017

Hematopoietic stem cell transplantation (HSCT) offers potentially curative therapy for many hematologic and nonhematologic conditions. As a successful outcome of Qatar’s National Cancer Strategy, the HSCT program was started in the National Center for Cancer Care and Research (NCCCR) in October 2015. The HSCT program in NCCCR is the only transplant program in Qatar and self-sufficient with all three core components: the stem cell collection facility, the stem cell processing facility, and the clinical program, which are locally available at Hamad Medical Corporation. In this paper, we report on the outcomes of the first 16 patients who underwent autologous stem cell transplantations (ASCTs) in our center. A total of 17 ASCT have been performed for 16 adult (≥14 years) patients. Thirteen of the 16 patients were eligible for disease evaluation at Day 100 post-ASCT. Among these patients, the overall response rate on Day 100 was 92% (complete remission, 61%; very good partial remission/partial remission, 31%) and stable disease occurred in 6%. The procedure was very well tolerated by all patients. At the time of writing this report, all patients are alive; however, one patient (6%) had disease relapse. The Day 100 post-ASCT nonrelapse mortality rate was 0%. Launching the HSCT program represents a historic milestone in the development of the health-care sector in Qatar. The 1st year of this program was very fruitful with the accomplishment of 17 successful transplants. We are in the process of starting the allogenic HSCT early next year. This would represent the next significant milestone for cancer care in Qatar.
Leveraging social and digital media for participant recruitment: A review of methods from the Bayley Short Form Formative Study
Authors: Burke-Garcia Amelia , Mathew Sunitha
Published: June 2017

Introduction

Social media is increasingly being used in research, including recruitment.

Methods

For the Bayley Short Form Formative Study, which was conducted under the the National Children’s Study, traditional methods of recruitment proved to be ineffective. Therefore, digital media were identified as potential channels for recruitment.

Results

Results included successful recruitment of over 1800 infant and toddler participants to the Study.

Conclusions

This paper outlines the methods, results, and future research opportunities.
The Normative Authority of Social Practices: A Critical Theoretical Reading of Hegel’s Introduction to thePhilosophy of Right
Authors: Lima Erick
Published: June 2017

What follows is an attempt to interpret Hegel’s Introduction to thePhilosophy of Rightin a way that explores the thesis of reason’s social character in light of the recent debate on Hegel’s theory of practical normativity. The discussion aims to highlight Hegel’s commitment to a ‘reconstructive’ version of the ‘immanent transcendence’ motive of Critical Theory and, more generally, to a programmatic critique of ‘deficient’ rationality and its effects on practice.
An unknown Phanerozoic driver of brachiopod extinction rates unveiled by multivariate linear stochastic differential equations
Authors: Reitan Trond , Liow Lee Hsiang
Published: June 2017

Whether the evolutionary dynamics of one group of organisms influence that of another group of organisms over the vast timescale of the geological record is a difficult question to tackle. This is not least because multiple factors can influence or mask the effects of potential driving forces on evolutionary dynamics of the focal group. Here, we show how an approach amenable to causality inference for time series, linear stochastic differential equations (SDEs), can be used in a multivariate fashion to shed light on driving forces of diversification dynamics across the Phanerozoic. Using a new, enhanced stepwise search algorithm, we searched through hundreds of models to converge on a model that best describes the dynamic relationships that drove brachiopod and bivalve diversification rates. Using this multivariate framework, we characterized a slow process (half-life of c. 42 Myr) that drove brachiopod extinction. This slow process has yet to be identified from the geological record. Using our new framework for analyzing multiple linear SDEs, we also corroborate our previous findings that bivalve extinction drove brachiopod origination in the sense that brachiopods tended to diversify at a greater rate when bivalves were removed from the system. It is also very likely that bivalves “self-regulate” in the sense that bivalve extinctions also paved the way for higher bivalve origination rates. Multivariate linear SDEs as we presented them here are likely useful for studying other dynamic systems whose signatures are preserved in the paleontological record.
Ixodes kangdingensis (Acari: Ixodidae), a new species from the Siberian weasel, Mustela sibirica (Carnivora: Mustelidae) in China
Authors: GUO TIANYU , SUN YI , XU GUANG , DURDEN LANCE A.
Published: June 2017

The female and nymph of Ixodes (Pholeoixodes) kangdingensis n. sp. are described based on both morphology and analysis of 16S rRNA gene sequences. Specimens of this new tick species were collected from a Siberian weasel (Mustela sibirica) in Kangding County, Sichuan Province, China. The morphological features of the female and nymph are unique to distinguish I. kangdingensis n. sp. from other members of the subgenus Pholeoixodes, including the presence of distinctly shaped cornua, anterior and posterior processes on palpal article I and a large angular projection on each side of the hypostome. Partial sequence of 16S rRNA gene grouped this species with Ixodes arboricola and Ixodes lividus with sequence divergence of new species from I. arboricola 4·16% and from I. lividus 8·49%. Data on the phylogenetic position, hosts, geographic distribution and key to females of closely related species are also provided.
Radiocarbon Dating of Barrows of the Pazyryk, Karakoba, and Bystrianka Cultures from the Manzherok Region, Russia
Authors: Borodovskiy Andriey P , Krąpiec Marek , Oleszczak Łukasz
Published: June 2017

This paper presents radiocarbon (14C) dating of Scythian period sites discovered in Northern Altai, Russia, in the 1990s, including large, unlooted barrow cemeteries in the Manzherok region. The results indicate that barrows attributed to the Karakoba culture may represent a long time span from the beginning of the 9th century BC until the beginning of 1st century BC, while those linked with the North Pazyryk culture generally keep within the Scythian period: from the beginning of the 5th century BC to the late 1st century AD. 14C analysis has confirmed the viability of traditional archaeological dating and the contemporaneity of barrows belonging to various cultural traditions (North Pazyryk, Karakoba), and also allowed correlating the horizons of burials to the seismic phenomena observed at the site.
Women's Legislative Underrepresentation: Enough Come Forward, (Still) Too Few Chosen
Authors: Ashe Jeanette
Published: June 2017

No established liberal democracy has achieved sex balance in its national legislature. Scholars agree skewed candidate pools put forward by parties during elections cause sex-disproportionate seat distribution, but disagree as to whether disproportionality is caused by too few women aspirant candidates coming forward (supply) or party selectors preferring men (demand). This paper uses a multistage method to explore supply and demand during the British Labour party's candidate selection process. Rare data from three elections and 4622 aspirants allow for an unobstructed look inside the secret garden of politics and reveal the party is not fully feminized insofar that women aspirants are disproportionally filtered out of its selection process and are disproportionally underrepresented in its candidate pool. Testing reveals a lack of selector demand for women aspirants has a greater impact on women's underrepresentation than an undersupply of women aspirants, a finding which supports using sex quotas to level imbalanced candidate slates.
Pope Innocent III and the Annulment of Magna Carta
Authors: HELMHOLZ RICHARD
Published: June 2017

Historians have offered a variety of explanations for Pope Innocent III's release of King John from the promise that he made to observe the clauses of Magna Carta. None has won general acceptance. This article proposes an alternative by examining the tenets of the canon law as it was understood in 1215. That examination shows that the law of oaths (De iureiurando) played a central role in canonistic thought of the time. It contained the juristic resources that made it possible for Innocent to release John from the oath that he had taken at Runnymeade.
Taxonomy of Nystiellidae (Caenogastropoda, Epitonioidea) from Brazil, with description of three new species from the South-western Atlantic
Authors: Pimenta Alexandre Dias , Andrade Bruno Garcia , Absalão Ricardo Silva
Published: June 2017

A taxonomic revision of the Nystiellidae from Brazil, including samples from the Rio Grande Rise, South Atlantic, was performed based on shell morphology. Five genera and 17 species were recognized. For the richest genus,Eccliseogyra, the three species previously recorded from Brazil were revised:E. brasiliensisandE. maracatu, previously known only from their respective type series, were re-examined. Newly available material ofE. maracatuexpanded the known geographic range of this species to off south-east Brazil.Eccliseogyra nitidais now recorded from north-eastern to south-eastern Brazil, as well as from the Rio Grande Rise. Three species ofEccliseogyraare newly recorded from the South Atlantic:E. monnioti, previously known from the north-eastern Atlantic, occurs off eastern Brazil and on the Rio Grande Rise; its protoconch is described for the first time, confirming its family allocation.Eccliseogyra pyrrhiasoccurs off eastern Brazil and on the Rio Grande Rise, andE. folinioff eastern Brazil. The genusIphitusis newly recorded from the South Atlantic.Iphitus robertsiwas found off northern Brazil, although the shells show some differences from the type material, with less-pronounced spiral keels. Additional new finds showed thatIphitus cancellatusranges from eastern Brazil to the Rio Grande Rise, and Iphitusnotiossp. nov. is restricted to the Rio Grande Rise.Narrimania, previously recorded from Brazil based on dubious records, is confirmed, including the only two living species described for the genus:N. azelotes, previously only known from the type locality in Florida, andN. concinna, previously known from the Mediterranean. A third species,Narrimania raquelaesp. nov. is described from eastern Brazil, diagnosed by its numerous and thinner cancellate sculpture. To the three species ofOpaliopsispreviously known from Brazil, a fourth species,O. arnaldoisp. nov., is added from eastern Brazil, and diagnosed by its very thin spiral sculpture, absence of a varix, and thinner microscopic parallel axial striae.Papuliscala nordestina, originally described from north-east Brazil, is recorded off eastern Brazil and synonymized withP. elongata, a species previously known only from the North Atlantic.
Composing music, developing dialogues: An enactive perspective on children's collaborative creativity
Authors: Veloso Ana Luísa
Published: June 2017

This study aims to provide new insights on the nature of the embodied and collaborative processes related to the emergence of new musical ideas that occur when children are composing in groups.

Data was obtained by participant observation of the teacher/researcher and by ten videotaped one-hour musical sessions dedicated to the development of a music composition by two groups of children, all of whom were eight years old.

It was found that when composing in groups a) children use embodied processes to transform what they experience on diverse realms of their existence into musical ideas, and that b) while creating music, children engage in several improvisatory moments where new ideas emerge through the diverse ways they enact the surroundings where the activity is occurring. Findings suggest a conception of music composing as a multidimensional phenomenon that entails cognitive processes that are distributed across and beyond the physical body. Findings also suggest that composing music in collaboration with others nurtures a set of creative possibilities that would otherwise, not occur. Considerations for music education theory and practice are addressed in the last section of the article.
Changing Property-Rights Regimes: A Study of Rural Land Tenure in China
Authors: Brandt Loren , Whiting Susan H. , Zhang Linxiu , Zhang Tonglong
Published: June 2017

Through two rounds of land contracting, rural households have been allocated a bundle of rights in land. We observe significant differences across villages in the amount of land to which villagers retain a claim and the institutional mechanisms governing the exchange of land rights. This study reveals the perpetuation and expansion of non-market mechanisms accruing to the benefit of village cadres and state officials and only limited emergence of market mechanisms in which households are primary beneficiaries. It identifies factors in economic, political and legal domains that incentivize and enable state officials and local cadres to capture returns from use of land. Relatedly, the study finds differences in conflict over property-rights regimes. Drawing on a pilot survey carried out by the authors in November of 2011 in Shaanxi and Jiangsu provinces (192 households in 24 villages), this paper seeks to explain heterogeneity and change in property-rights regimes over time and across space.
Clingcon: The next generation
Authors: BANBARA MUTSUNORI , KAUFMANN BENJAMIN , OSTROWSKI MAX , SCHAUB TORSTEN
Published: June 2017

We present the third generation of the constraint answer set systemclingcon, combining Answer Set Programming (ASP) with finite domain constraint processing (CP). While its predecessors rely on a black-box approach to hybrid solving by integrating the CP solvergecode, the newclingconsystem pursues a lazy approach using dedicated constraint propagators to extend propagation in the underlying ASP solverclasp. No extension is needed for parsing and groundingclingcon's hybrid modeling language since both can be accommodated by the new generic theory handling capabilities of the ASP groundergringo. As a whole,clingcon3 is thus an extension of the ASP systemclingo5, which itself relies on the groundergringoand the solverclasp. The new approach ofclingconoffers a seamless integration of CP propagation into ASP solving that benefits from the whole spectrum ofclasp's reasoning modes, including, for instance, multi-shot solving and advanced optimization techniques. This is accomplished by a lazy approach that unfolds the representation of constraints and adds it to that of the logic program only when needed. Although the unfolding is usually dictated by the constraint propagators during solving, it can already be partially (or even totally) done during preprocessing. Moreover,clingcon's constraint preprocessing and propagation incorporate several well-established CP techniques that greatly improve its performance. We demonstrate this via an extensive empirical evaluation contrasting, first, the various techniques in the context of CSP solving and, second, the newclingconsystem with other hybrid ASP systems.
The Christian Hermeneutics of Cranmer’s Homilies
Authors: Briggs Richard S.
Published: June 2017

This article explores some of the hermeneutical resources of the two official books of homilies, authorized to be preached in the BCP communion service. The historical contexts and successive editions of the books are explained, and a focused reading is offered of the key texts relevant to the interpretation of Scripture. Some consideration is given to other related texts that highlight Cranmer’s hermeneutical approach. It is suggested that Cranmer’s use of Scripture is not in practice the approach he commends in the first homily, but is driven by concerns with attaining the ‘right’ doctrine of justification. A key issue is the interplay between readerly character, deferral to wise readers, and the pressure of the text against particular traditions. It is argued that the Books of Homilies here offer rich material for reflection upon the nature of Christian hermeneutics in one particular ecclesial tradition, and indicate an Anglican approach to Scripture that has much to offer.
Factor Structure of the Social Phobia and Anxiety Inventory for	Children in an Irish Adolescent Population
Authors: Fitzgerald Amanda , Rawdon Caroline , O’Rourke Claire , Dooley Barbara
Published: June 2017

Abstract. The Social Phobia and Anxiety Inventory for Children (SPAI-C) is a 26-item, empirically derived, self-report measure, which assesses symptoms of social phobia based on DSM-IV criteria. Previous studies have examined the factor structure of the SPAI-C and suggested three-, four-, and five-factor models. However, differences in the underlying factor structures reported may be due to misuse of analytic methods or use of mixed samples, rather than meaningful differences in the underlying presentation of social anxiety. We tested all previously published factor structures in an Irish community-based adolescent sample. Confirmatory factor analysis (CFA) and DSM-5 criteria supported the five-factor structure proposed by Aune, Stiles, and Svarva (2008) including Assertiveness, Physical/Cognitive Symptoms, Public Performance, Social Encounters, and Avoidance factors. Findings suggest that the Social Phobia and Anxiety Inventory for Children (SPAI-C) is relevant to DSM-5 criteria for social anxiety disorder (SAD) and is appropriate for use with older adolescents outside of the USA.
Replicability of the Psychometric Properties of Trait-Levels Measures	of Spontaneous and Deliberate Mind Wandering
Authors: Chiorri Carlo , Vannucci Manila
Published: June 2017

Abstract. Recent research on individual differences in mind wandering has shown that two different forms, spontaneous and deliberate, can be distinguished and measured with the Mind Wandering-Spontaneous (MW-S) and the Mind Wandering-Deliberate (MW-D) scales. In this study we tested whether the psychometric properties of Italian versions of these scales replicated across two common administration methods (paper-and-pencil and online survey). We also investigated their construct validity with respect to other self-report measures of MW and daydreaming, and measures of attentional control (AC). These measures were completed by 123 psychology students using the paper-and-pencil versions and by 165 online participants. The factor structure of the MW scales and their correlations with the other measures were replicated almost perfectly across administration methods. A confirmatory factor analysis (CFA) performed on data from 270 community participants further supported the replicability of the factor structure of the MW and AC scales. Albeit moderately correlated, the MW-S and the MW-D scales showed discriminant validity, since the former had significantly higher correlations with the other MW and AC measures, but not with daydreaming. These findings further supported the distinctiveness of the two forms of MW and suggested that in correlational studies the administration method is unlikely to affect results.
The Relation Between Financial Incentives, Motivation, and Performance
Authors: Thibault Landry Anaïs , Gagné Marylène , Forest Jacques , Guerrero Sylvie , Séguin Michel , Papachristopoulos Konstantinos
Published: June 2017

Abstract. To this day, researchers are debating the adequacy of using financial incentives to bolster performance in work settings. Our goal was to contribute to current understanding by considering the moderating role of distributive justice in the relation between financial incentives, motivation, and performance. Based on self-determination theory, we hypothesized that when bonuses are fairly distributed, using financial incentives makes employees feel more competent and autonomous, which in turn fosters greater autonomous motivation and lower controlled motivation, and better work performance. Results from path analyses in three samples supported our hypotheses, suggesting that the effect of financial incentives is contextual, and that compensation plans using financial incentives and bonuses can be effective when properly managed.
KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL
Authors: Kurt Ibrahim Cagri , Sur Ilknur , Kaya Ezgi , Cingoz Ahmet , Kazancioglu Selena , Kahya Zeynep , Toparlak Omer Duhan , Senbabaoglu Filiz , Kaya Zeynep , Ozyerli Ezgi , Karahüseyinoglu Sercin , Lack Nathan A , Gümüs Zeynep H , Onder Tamer T , Bagci-Onder Tugba
Published: June 2017

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively kill tumor cells. TRAIL resistance in cancers is associated with aberrant expression of the key components of the apoptotic program. However, how these components are regulated at the epigenetic level is not understood. In this study, we investigated novel epigenetic mechanisms regulating TRAIL response in glioblastoma multiforme (GBM) cells by a short-hairpin RNA loss-of-function screen. We interrogated 48 genes in DNA and histone modification pathways and identified KDM2B, an H3K36-specific demethylase, as a novel regulator of TRAIL response. Accordingly, silencing of KDM2B significantly enhanced TRAIL sensitivity, the activation of caspase-8, -3 and -7 and PARP cleavage. KDM2B knockdown also accelerated the apoptosis, as revealed by live-cell imaging experiments. To decipher the downstream molecular pathways regulated by KDM2B, levels of apoptosis-related genes were examined by RNA-sequencing upon KDM2B loss, which revealed derepression of proapoptotic genes Harakiri (HRK), caspase-7 and death receptor 4 (DR4) and repression of antiapoptotic genes. The apoptosis phenotype was partly dependent on HRK upregulation, as HRK knockdown significantly abrogated the sensitization. KDM2B-silenced tumors exhibited slower growth in vivo. Taken together, our findings suggest a novel mechanism, where the key apoptosis components are under epigenetic control of KDM2B in GBM cells.
Ubiquitin-dependent regulation of Cdc42 by XIAP
Authors: Murali Arun , Shin Jaeyoung , Yurugi Hajime , Krishnan Aswini , Akutsu Masato , Carpy Alejandro , Macek Boris , Rajalingam Krishnaraj
Published: June 2017

Rho GTPases control fundamental cellular processes and Cdc42 is a well-studied member of the family that controls filopodia formation and cell migration. Although the regulation of Cdc42 activity by nucleotide binding is well documented, the mechanisms driving its proteostasis are not clear. Here, we demonstrate that the highly conserved, RING domain containing E3 ubiquitin ligase XIAP controls the protein stability of Cdc42. XIAP binds to Cdc42 and directly conjugates poly ubiquitin chains to the Lysine 166 of Cdc42 targeting it for proteasomal degradation. Depletion of XIAP led to an increased protein stability and activity of Cdc42 in normal and tumor cells. Consistently, loss of XIAP enhances filopodia formation in a Cdc42-dependent manner and this phenomenon phenocopies EGF stimulation. Further, XIAP depletion promotes lung colonization of tumor cells in mice in a Cdc42-dependent manner. These observations shed molecular insights into ubiquitin-dependent regulation of Cdc42 and that of actin cytoskeleton.
Myosin 7 and its adaptors link cadherins to actin
Authors: Yu I-Mei , Planelles-Herrero Vicente J. , Sourigues Yannick , Moussaoui Dihia , Sirkia Helena , Kikuti Carlos , Stroebel David , Titus Margaret A. , Houdusse Anne
Published: June 2017

Cadherin linkages between adjacent stereocilia and microvilli are essential for mechanotransduction and maintaining their organization. They are anchored to actin through interaction of their cytoplasmic domains with related tripartite complexes consisting of a class VII myosin and adaptor proteins: Myo7a/SANS/Harmonin in stereocilia and Myo7b/ANKS4B/Harmonin in microvilli. Here, we determine high-resolution structures of Myo7a and Myo7b C-terminal MyTH4-FERM domain (MF2) and unveil how they recognize harmonin using a novel binding mode. Systematic definition of interactions between domains of the tripartite complex elucidates how the complex assembles and prevents possible self-association of harmonin-a. Several Myo7a deafness mutants that map to the surface of MF2 disrupt harmonin binding, revealing the molecular basis for how they impact the formation of the tripartite complex and disrupt mechanotransduction. Our results also suggest how switching between different harmonin isoforms can regulate the formation of networks with Myo7a motors and coordinate force sensing in stereocilia.
Sodium vanadium titanium phosphate electrode for symmetric sodium-ion batteries with high power and long lifespan
Authors: Wang Dongxue , Bie Xiaofei , Fu Qiang , Dixon Ditty , Bramnik Natalia , Hu Yong-Sheng , Fauth Francois , Wei Yingjin , Ehrenberg Helmut , Chen Gang , Du Fei
Published: June 2017

Sodium-ion batteries operating at ambient temperature hold great promise for use in grid energy storage owing to their significant cost advantages. However, challenges remain in the development of suitable electrode materials to enable long lifespan and high rate capability. Here we report a sodium super-ionic conductor structured electrode, sodium vanadium titanium phosphate, which delivers a high specific capacity of 147 mA h g−1 at a rate of 0.1 C and excellent capacity retentions at high rates. A symmetric sodium-ion full cell demonstrates a superior rate capability with a specific capacity of about 49 mA h g−1 at 20 C rate and ultralong lifetime over 10,000 cycles. Furthermore, in situ synchrotron diffraction and X-ray absorption spectroscopy measurement are carried out to unravel the underlying sodium storage mechanism and charge compensation behaviour. Our results suggest the potential application of symmetric batteries for electrochemical energy storage given the superior rate capability and long cycle life.
Controlling heat and particle currents in nanodevices by quantum observation
Authors: Biele Robert , Rodríguez-Rosario César A. , Frauenheim Thomas , Rubio Angel
Published: June 2017

We demonstrate that in a standard thermo-electric nanodevice the current and heat flows are not only dictated by the temperature and potential gradient, but also by the external action of a local quantum observer that controls the coherence of the device. Depending on how and where the observation takes place, the direction of heat and particle currents can be independently controlled. In fact, we show that the current and heat flow in a quantum material can go against the natural temperature and voltage gradients. Dynamical quantum observation offers new possibilities for the control of quantum transport far beyond classical thermal reservoirs. Through the concept of local projections, we illustrate how we can create and directionality control the injection of currents (electronic and heat) in nanodevices. This scheme provides novel strategies to construct quantum devices with application in thermoelectrics, spintronic injection, phononics, and sensing among others. In particular, highly efficient and selective spin injection might be achieved by local spin projection techniques.
Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression
Authors: Rokavec Matjaz , Kaller Markus , Horst David , Hermeking Heiko
Published: June 2017

Epithelial-mesenchymal transition (EMT) plays an important role in tumor invasion and metastasis. A comprehensive, bioinformatics analysis of CCLE and TCGA datasets of seven tumor types allowed us to identify a novel pan-cancer EMT-associated gene expression signature consisting of 16 epithelial and 4 mesenchymal state-associated mRNAs. Among the identified epithelial cell state-associated factors, down-regulation of the RBM47 (RNA binding motif protein 47) mRNA displayed the most significant association with metastasis and poor survival in multiple cohorts of colorectal cancer (CRC) patients. Moreover, decreased RBM47 protein expression was associated with metastasis in a cohort of primary CRCs. RBM47 was directly suppressed during EMT induced by IL6-activated STAT3 or ectopic SNAIL and SLUG expression via conserved binding motifs of these factors within the RBM47 promoter. Moreover, RNAi-mediated down-regulation of RBM47 in CRC lines resulted in increased cell migration, invasion and metastases formation. As demonstrated by the example of RBM47, the EMT-associated signature characterized here allows to identify biomarkers for predicting clinical outcome of CRC and presumably other cancer entities. In addition, our functional analysis of RBM47 shows that the down-regulation of RBM47 during CRC progression may promote EMT and metastasis.
Lactate dehydrogenase A promotes the invasion and proliferation of pituitary adenoma
Authors: An Jiayin , Zhang Yin , He Jiaojiang , Zang Zhenle , Zhou Zheng , Pei Xiangdong , Zheng Xin , Zhang Weihua , Yang Hui , Li Song
Published: June 2017

Lactate dehydrogenase A (LDHA) has been reported to be involved in the initiation and progression of tumors. However, the potential role of LDHA in pituitary adenoma (PA) remains unknown. In this study, we showed that the expression levels of LDHA mRNA and protein were significantly elevated in invasive PA samples, and positively correlated with higher Ki-67 index. Overexpression of LDHA in a PA cell line (GH3) promoted glucose uptake through the upregulation of glucose transporter-1 (Glut1), lactate secretion and induced cellular invasion by upregulation of matrix metalloproteinase2 (MMP2). LDHA also promoted GH3 cell proliferation through induction of cell cycle progression via activation of the Akt-GSK-3β-cyclinD1 pathway. Accordingly, oxamate-induced inhibition of LDHA suppressed glucose uptake, lactate secretion, invasion and proliferation in GH3 cells via down regulation of Glut1 and MMP2 expression and inhibition of the Akt-GSK-3β-cyclinD1 pathway. Moreover, oxamate induced GH3 cell apoptosis by increasing mitochondrial reactive oxygen species (ROS) generation. In vivo, LDHA overexpression promoted tumor growth, and oxamate delayed tumor growth. In primary PA cell cultures, oxamate also effectively suppressed invasion and proliferation. Our data indicate that LDHA is involved in promoting the progression of PA, and oxamate might be a promising therapeutic agent for the treatment of PA.
DFT-inspired methods for quantum thermodynamics
Authors: Herrera Marcela , Serra Roberto M. , D’Amico Irene
Published: June 2017

In the framework of quantum thermodynamics, we propose a method to quantitatively describe thermodynamic quantities for out-of-equilibrium interacting many-body systems. The method is articulated in various approximation protocols which allow to achieve increasing levels of accuracy, it is relatively simple to implement even for medium and large number of interactive particles, and uses tools and concepts from density functional theory. We test the method on the driven Hubbard dimer at half filling, and compare exact and approximate results. We show that the proposed method reproduces the average quantum work to high accuracy: for a very large region of parameter space (which cuts across all dynamical regimes) estimates are within 10% of the exact results.
Developmental validation of a 6-dye typing system with 27 loci and application in Han population of China
Authors: Liu Yaju , Guo Lihong , Jin Haiying , Li Zheng , Bai Rufeng , Shi Meisen , Ma Shuhua
Published: June 2017

In this study, a novel 27-locus system (now known as the SureID PanGlobal system), including 24 autosomal STRs (D3S1358, TH01, D21S11, D18S51, Penta E, D12S391, D6S1043, D2S1338, D1S1656, D2S441, D5S818, D13S317, D7S820, D19S433, CSF1PO, Penta D, vWA, D8S1179, TPOX, FGA, D16S539, D22S1045, SE33, D10S1248), two Y-chromosome markers (DYS391 and Y-indel) and the sex determining marker, Amelogenin was developed with six fluorescent dyes labeling. The included STR loci belonged to the core loci in the Combined DNA Index System (CODIS) and the European Standard Set (ESS) as well as some additional loci commonly used in commercial kits and national DNA databases. This paper describes the validation studies conducted with the SureID PanGlobal system using Applied Biosystems 3500 XL Genetic Analyzer for fragment length detection that included the analysis of the following parameters and aspects: PCR conditions, sensitivity, species specificity, inhibition, precision, stutter, DNA mixtures, and stability studies with crime scene samples. The studies demonstrated that the SureID PanGlobal system is reproducible, accurate, sensitive and robust for forensic application and databasing. Additionally, the whole cycling time of the system can finish within 65 minutes, which was developed specifically for rapid and reliable generation of DNA profiles obtained from blood, buccal swabs and forensic stains.
Liver Fat, Hepatic Enzymes, Alkaline Phosphatase and the Risk of Incident Type 2 Diabetes: A Prospective Study of 132,377 Adults
Authors: Chen Sean Chun-Chang , Tsai Shan Pou , Jhao Jing-Yun , Jiang Wun-Kai , Tsao Chwen Keng , Chang Ly-Yun
Published: June 2017

Previous studies have reported inconsistent results of the associations of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) with incident type 2 diabetes (diabetes hereafter). We aimed to resolve the controversy by taking nonalcoholic fatty liver disease (NAFLD) into account. The study population comprised 132,377 non-diabetic individuals (64,875 men and 67,502 women) aged 35–79 who had two or more health examinations during 1996–2014. A total of 6,555 incident diabetes (3,734 men and 2,821 women) were identified, on average, over 5.8 years of follow-up. Cox regression was used to calculate the hazard ratio (HR) for incident diabetes, adjusting for classical confounders. The risk of incident diabetes was significantly associated with NAFLD [HR = 2.08 (men) and 2.65 (women)]. Elevated ALT, AST, GGT and ALP were also significantly associated with the increased risk of diabetes, with HRs of 1.27, 1.23, 1.58 and 1.37, respectively, in men, and 1.56, 1.18, 1.48 and 1.44, respectively in women. Our results suggest that NAFLD, ALT, AST, GGT and ALP are independent predictors for incident diabetes in both men and women.