bluuebunny/crossref_metadata_2025 huggingface dataset:
Estilo de vida dos estudantes de Medicina e adoecimento mental: Um protocolo de revisão sistemática
Authors: Flach Jemima de Oliveira Souza , Evangelista Renata Alessandra , Bueno Alexandre de Assis
Published: June 2024

O estilo de vida desempenha um papel crucial na determinação de certas condições mentais e médicas. Este artigo tem como objetivo apresentar um protocolo para avaliar, com base em evidências científicas da literatura, a associação entre o estilo de vida dos estudantes de medicina e o adoecimento mental durante a graduação. Método de revisão: o protocolo deste estudo foi desenvolvido conforme as diretrizes PRISMA para protocolos de revisão sistemática e será registrado na base de dados PROSPERO. A busca será realizada nas seguintes bases de dados: Scopus, EMBASE, SciELO e MEDLINE via PubMed. A literatura cinzenta também será incluída na pesquisa. Dois revisores independentes e cegos participarão da seleção dos estudos. A qualidade das evidências será analisada utilizando os instrumentos do Joanna Briggs Institute. A análise quantitativa dos estudos incluídos será apresentada por meio de uma metanálise; caso isso não seja viável, os dados serão apresentados através de uma análise descritiva. A revisão sistemática e a metanálise de estudos sobre etiologia e risco podem fornecer informações valiosas para profissionais de saúde e formuladores de políticas, esclarecendo os fatores de risco das doenças e identificando áreas onde outros fatores, além das intervenções diretas com terapia e tratamento, podem influenciar os resultados de saúde. Considerações finais: Identificar a relação entre estilo de vida e fatores desencadeantes de adoecimento mental é essencial para orientar a implementação e desenvolvimento de alternativas que melhorem o estilo de vida dos estudantes.
Da lei à prática: Analisando os desafios regulatórios no contexto das farmácias comerciais brasileiras
Authors: Maciel Alexandre Alves , Barros Anna Thalita Nunes de , Oliveira Maysa Boaventura , Pereira Gustavo José Vasco
Published: June 2024

No mundo das farmácias comerciais, a intersecção entre a legislação e a prática diária é um desafio constante. Enquanto as leis e regulamentos buscam garantir a qualidade, segurança e eficácia dos produtos farmacêuticos, a aplicação destas normativas muitas vezes apresenta obstáculos no ambiente comercial. Este estudo tem por objetivo analisar os desafios regulatórios enfrentados pelas farmácias comerciais brasileiras. A abordagem metodológica no processo de desenvolvimento desse estudo foi a revisão integrativa da literatura, um método que permite a integração de conhecimento através de um processo metódico e rigoroso. Dessa forma, foram selecionados 17 artigos que serviram de base para a produção desta revisão integrativa. As regulamentações exigem que as farmácias atendam a uma série de critérios técnicos, estruturais e de segurança, o que pode ser desafiador para os estabelecimentos comerciais. Sendo assim, a necessidade de cumprir todas as exigências legais, bem como manter-se atualizado com as constantes mudanças nas normas, torna o processo de regularização das farmácias comerciais uma tarefa complexa e que demanda constante atenção e cuidado por parte dos responsáveis pelo estabelecimento. Em conclusão, o processo de regularização de farmácias comerciais no Brasil é intrinsecamente complexo e desafiador, exigindo um compromisso contínuo com a conformidade regulatória, a educação dos profissionais e a adaptação às mudanças legislativas. A superação desses desafios é crucial para garantir a segurança dos pacientes e a eficácia dos serviços farmacêuticos, promovendo uma prática ética e de qualidade no setor.
Perspectiva anatômica e ética da caudectomia em cães
Authors: Mothé Gabriele Barros , Ferraz Vera Lúcia Teixeira , Dias Ana Luiza Souza , Duarte Gabriella da Silva , Brito Julia Barbosa de , Nascimento Raphael Espínola David do , Procopiak Reika Sato , Lameira Yasmin Xavier , Lima Renata Vieira Cerqueira , Mendes Junior Aguinaldo Francisco
Published: June 2024

As vértebras caudais caninas compõem a cauda do cão, variando em número e tamanho entre as raças, e são fundamentais para o equilíbrio, comunicação e expressão emocional. A caudectomia é um procedimento cirúrgico de amputação dessas vértebras. No entanto, quando por motivos estéticos ou culturais, essa prática tem gerado debates intensos e controvérsias significativas, levantando questionamentos sobre a justificativa para sua continuação. Baseado nisso, este trabalho tem o objetivo de descrever a anatomia das vértebras dos cães e a caudectomia, destacando os danos potenciais que tal mutilação pode causar nesses animais, apoiando-se em uma revisão da literatura.  Pesquisas indicam que a cauda é essencial não apenas para a comunicação canina, permitindo aos cães expressarem uma gama de emoções e intenções, mas também desempenha um papel crucial no equilíbrio, especialmente durante a corrida e ao realizar movimentos ágeis. A remoção da cauda pode, portanto, interferir significativamente no comportamento e na capacidade de expressão corporal dos cães, além de potencialmente causar dor, desconforto no período pós-operatório e levar a complicações sérias, como infecções e o desenvolvimento de neuroma de amputação, uma condição dolorosa que ocorre no coto da amputação. Atualmente, muitos países têm adotado leis e regulamentações que restringem ou proíbem a caudectomia em cães, exceto quando necessária por razões médicas. A crescente conscientização sobre o bem-estar animal tem levado a uma mudança de atitude em relação a essa prática, com mais tutores optando por manter a cauda natural de seus cães.
Dilbilgisinin Rivayet Lafızları Arasında Tercihe Etkisi: Dilci Şârih Tûribiştî Örneğinde Bir İnceleme
Authors: Aslan Zahir
Published: June 2024

Dil kurallarının oluşumunda belli bir standarda ulaşmak uzun bir sürecin neticesinde ortaya çıkmıştır. Dil bilginleri, kuralların belirlenmesinde istişhâd kaynağı olarak Kur’ân-ı Kerim ve klasik şiir üzerinde fikir birliğinde olurken, hadislerle istişhâd konusunda ise ihtilafa düşmüştür. Mana ile rivayet, senedde dile vakıf olmayan râvilerin varlığı ve istinsah hataları gibi etkenler bu ihtilafın temel dayanakları arasında gösterilebilir. Öte yandan temel gayesi hadislerin anlaşılması olan şerhler birçok konunun yanı sıra dil tahlillerine de yer vermiştir. Dile dair değerlendirmelerin yoğun olduğu hadis şerhlerinin dil açısından çalışılması rivayetlerin anlaşılmasına önemli katkı sunacaktır. Tûribiştî’nin kaleme aldığı el-Müyesser fî Şerhi Mesâbîhi’s-Sünne adlı şerh de Mesâbîhu’s-Sünne’de geçen rivayetlerin metinlerini bir dilci gibi tahkik etmiş, mukayeselerde bulunmuş ve detaylı açıklamalar yapmıştır. Bu çalışmada Tûribiştî’nin rivayet metinlerinde geçen kelimeleri/cümleleri nasıl tahlil ettiği, anladığı ve yorumladığı anlaşılmaya çalışılmıştır. Ayrıca yapılan değerlendirmelerin rivayet tercihine etkisi inceleme konusu edilmiştir. Müellif eserinde dilbilgisi ve hadis ilmine olan vukufiyetiyle önemli bir birikim ortaya koymuştur. Metinlerin dil açısından tahlilinde muhakkik bir metotla değerlendirmeler yapan müellif, görüldüğü kadarıyla çoğunlukla rivayet lafızlarının tercihinde nakli öncelemiştir.
Combination Concept of LSB and PlayFair Cipher for Optimizing Data Security
Authors: Hidajat Moch. Sjamsul , Ery Mintorini
Published: June 2024

Data security is now something that is very necessary, with the aim of ensuring that important data and information does not fall into the hands of unauthorized people. The widespread data exchange process provides opportunities for unauthorized parties to take, copy or steal the exchanged data. This is what triggers the importance of securing data when exchange occurs. In the field of computer science, there are many ways that data can be secured. These methods include the concepts of steganography and cryptography. Steganography is a way to hide data in various media, while cryptography is a way to encode data into a form that has no meaning. This research aims to design a system to secure messages in the form of text data using the Playfair cipher cryptography method and Least Significant Bit (LSB) steganography using image media and the image containing the message is not visible to the eye that the image contains a secret message
Authoritarian Parenting Practices on Korean Drama: Reception Analysis on SKY Castle
Authors: Primadini Intan , Setianoto Fiona Angeline
Published: June 2024

With a rating of 23.78%, the Korean drama "SKY Castle" had the highest rating amongst Korean dramas. Authoritarian parenting is discussed in this South Korean drama. 87% of students believe that they are in the wrong major, which expressed how this not only happened in South Korea but also in Indonesia. Authoritarian parents pressured them to join specific majors. This is a result of the stereotypes of majors in which parents hope will ensure students' success and financial stability. This authoritarian parenting style harms children’s mental health. The post-positivist perspective and the case study approach are both used in this descriptive qualitative study. In-depth interview data collecting and recording techniques, data validity techniques including construction validity, and pattern matching data analysis techniques are all used in this study. According to the study's findings, the audience's parents have preconceived notions about particular universities and majors, which have an effect on their children's mental health and relationships with their parents. It may be stated that viewers who were educated by authoritarian parents are in a negotiated position since each viewer has a unique viewpoint on authoritarian parenting in the Korean drama "SKY Castle" based on their own cultural background and experiences.
The role of the Institute of Oriental Studies named after academician Ziya Bunyadov of the National Academy of Sciences of Azerbaijan in the study of Arabic literature
Authors:   Azerbaijan Institute of Theology, Alimuradov Ilkin
Published: June 2024

Language‟s definition varies in the literature. One of the most accurate definitions of language is that the language is the voice through which people express their purpose, it is a tool for communication, understanding and interaction between people, and this is a phenomenon that reflects human knowledge and culture. At the same time, it is a powerful factor that animates people and helps them to develop and thrive. The beauty of the language is reflected in examples of poetry and prose of folk literature. It is one of the most famous and widely spoken languages in the world. Arabic is the language of science and culture and helps to transmit religious, scientific and literary knowledge throughout history. There is no doubt that Arabic literature emphasizes the beauty of the Arabic language from preIslamic times to the present day. Arabic literature attracts the attention of the whole world, both ancient and modern. One of the countries where the Arabic language and its literature is taught is Azerbaijan. There are universities and institutes that contain faculties of Arabic literature and its departments. One of the scientific institutions that study the Arabic literature is the Institute of Oriental Studies named after Ziya Bunyadov of the National Academy of Sciences of Azerbaijan. It should be noted that the most important results of scientific research and books of the Institute are used in educational institutions within the country and abroad.
Philosophical analysis of the western European personalism
Authors:   Khazar University, Khalilov Ruslan
Published: June 2024

The problems of individualism and especially personalism have always been one of those issues that have always attracted the attention of philosophical thought. This means that a person preserves his characteristics, originality and uniqueness in his relations with society. First of all, if we talk about the importance of identifying this problem, then, in essence, this is the study of its holistic and comprehensive nature, based on indicators that are characteristic of a particular person. It is not so easy to complete this task. Because we are talking about learning a process that begins with distinguishing a certain person from others and continues to form his uniqueness and define his existence. A person who comes into the world as an individual can become a being capable of activity, self-awareness and personality. Particularly, for the normal functioning and development of society each of its members needs a certain amount of uniqueness. And the diversity of members of society, the existence of distinct personalities ensures the true richness of each social structure and its culture. Therefore, the fact that people have individual uniqueness is also accepted as a pattern of social development. And we will be able to follow these processes in the ideas of the European personalists that we will talk about.
1924-YEAR BANKNOTES OF THE MILITARY CONSUMPTION SOCIETY UNDER THE AZERBAIJAN SHOOTING DIVISION
Authors:   Researcher, notaphilist, Zeiniev Gabil , Mammadova Aygun ,   National Museum of History of Azerbaija
Published: June 2024

This paper investigates the history, color photos, and illustrations of the paper notes printed by the Military Consumption Society under the Caucasian Shooting Division for the first time in early 1924. Considering that there has not been sufficient research on this area and the uniqueness of the materials, the authors obtained new scientific findings by providing detailed notaphilic information. In the initial section, the paper presents the history of the First Iron Shooting Regiment named after 26 Baku Commissars and the Third Caucasian Shooting Regiment, pertaining to the Azerbaijan Shooting Division, as well as discusses the role of the Military Consumption Society in providing financial support to the staff members of the division. It also includes photos of personalities distinguished by their activities and services. In the following sections of the paper, the issuers, denominations, characteristics, and various aspects of the main factual material of the research are covered. Materials added to these sections are the crest stamp of the First Iron Shooting Regiment Model Unit on loan checks printed in early 1924, additional stamps, and illustrations of the check of the Third Caucasian Shooting Regiment under the Azerbaijan Shooting Division. The paper catalogues, which has never been done before, the banknotes belonging to the Military Consumption Society of the Azerbaijan Shooting Division. Paper money tokens consumed by the Military Consumption Society of the Azerbaijan Shooting Division in 1924 are rare and unique facts. In modern collection circulation, such materials and copies are few, and those in complete condition are rare (especially checks of the Third Caucasian Shooting Regiment). They were in circulation for a short period of time, and at a later stage, they were taken out of use and completely destroyed.
LOVE AS A FATAL EMOTION
Authors:   Theology Institute of Azerbaijan, Mahmandarov Dashdamir
Published: June 2024

This article explores the notion that human behaviors and desires can be attributed to someone called the “Other.” Throughout history, since Aristotle, it has been suggested that humans are imitative beings. Along with further developed versions of Aristotle`s concept of mimesis, the idea emerged that man actually imitates the desire of the “Other”. That is manifested not only in personal life, but also in all aspects of social life. In this article, the focus is specifically on love and how it can be understood through this theory. Contrary to contemporary interpretations of love, the argument is made that it is, in fact, a destructive (murderous) emotion. To support this claim, references to literature, psychoanalysis, literary criticism, and philosophy are made. It is claimed that love is not a feeling of happiness, but of crisis, hysterical fits and pain. Tolstoy`s Anna Karenina serves as an example of love`s tumultuous nature. The fact that people give different shades to this ancient feeling in the modern world parallels the change of the world and human understanding. In the modern world, people attempt to live a life free of pain, sterilized and unwounded which causes a change in the essence of love. The article emphasizes these features and describes the ancient essence of love.
The effect of lobbying activities on foreign policy decision making: the case of the USA
Authors:   Baku State University, Musayeva Aygun
Published: June 2024

The article discusses issues of lobbying and its influence on foreign policy decision-making in the United States. In modern international relations, parallel to the state, new actors are especially active. The activation of new actors affects the adoption of foreign policy decisions of the states, and even makes the state dependent on them in many cases. Among such new actors, we can mention transnational companies, non-governmental organizations, social movements, nationalliberation movements, as well as the activities of lobbies. In particular, the expansion of lobbying is observed in the leading states of the international relations system. The development of the modern stage of the socio-political system of the United States of America is characterized by the fact that the process of democratization gradually covers all aspects of the American society - economy, politics, ideology and spirituality, culture and way of thinking. The period after the World War is the period when the United States of America won the role of a superpower without losing it again. In the more recent 80s, Americans' struggle for democracy and civil rights intensified.
Behavior, long-term stress and relationship to owner in relinquished dogs
Authors: Sulonen Cornelia , Löf Jenny , Jensen Per , Lasses Karolina , Theodorsson Elvar , Quist Helena , Roth Lina S. V.
Published: June 2024

Dog ownership gained popularity during the pandemic. However, there was also a corresponding increase in the number of dogs being relinquished and rehomed. The rehoming procedure is known to be stressful to the dog, but the short- and long-term effects still need to be better understood. This study aimed to enhance our understanding of the short- and long-term challenges dogs encounter during the rehoming process by combining behavioral and physiological measures. The study included 20 relinquished dogs from a Swedish shelter and 30 rehomed dogs, comparing them to 33 control dogs that have been with their owner since leaving the breeder as puppies. All participants performed an unsolvable problem task, eye-contact test, and memory test and hair samples were obtained to analyze cortisol concentrations. Furthermore, dog owners (of rehomed and control dogs) completed a questionnaire assessing their perceived human-dog relationship. These owner-dog dyads also participated in a behavioral synchronization test. The result indicated that shelter dogs had the shortest eye-contact duration in both an eye-contact test and an unsolvable problem task, but there was no difference between the three groups in the short-term memory test or in stress-related behaviors. Analysis of hair cortisol concentrations in the dogs revealed that the shelter dogs had higher long-term stress levels than rehomed dogs, but they did not differ significantly from control dogs. Both rehomed and control dogs synchronized their behavior with their owner, but, interestingly, the owners of rehomed dogs reported a higher emotional closeness to their dogs than owners of control dogs. Consequently, despite the observed short-term effects during the rehoming procedure, this study suggests that rehomed dogs can adapt to their new life and develop a strong relationship with their owner.
RNAi-based Boolean gates in the yeast Saccharomyces cerevisiae
Authors: Tian Ximing , Volkovinskiy Andrey , Marchisio Mario Andrea
Published: June 2024

Boolean gates, the fundamental components of digital circuits, have been widely investigated in synthetic biology because they permit the fabrication of biosensors and facilitate biocomputing. This study was conducted to design and construct Boolean gates in the yeast Saccharomyces cerevisiae, the main component of which was the RNA interference pathway (RNAi) that is naturally absent from the budding yeast cells. We tested different expression cassettes for the siRNA precursor (a giant hairpin sequence, a DNA fragment—flanked by one or two introns—between convergent promoters or transcribed separately in the sense and antisense directions) and placed different components under the control of the circuit inputs (i.e., the siRNA precursor or proteins such as the Dicer and the Argonaute). We found that RNAi-based logic gates are highly sensitive to promoter leakage and, for this reason, challenging to implement in vivo. Convergent-promoter architecture turned out to be the most reliable solution, even though the overall best performance was achieved with the most difficult design based on the siRNA precursor as a giant hairpin.
Enhanced prediction of cement raw meal oxides by near-infrared spectroscopy using machine learning combined with chemometric techniques
Authors: Zhang Yongzhen , Yang Zhenfa , Wang Yina , Ge Xinting , Zhang Jianfeng , Xiao Hang
Published: June 2024

The component analysis of raw meal is critical to the quality of cement. In recent years, near-infrared (NIR) has been emerged as an innovative and efficient analytical method to determine the oxide content of cement raw meal. This study aims to utilize NIR spectroscopy combined with machine learning and chemometrics to improve the prediction of oxide content in cement raw meal. The Savitzky-Golay convolution smoothing method is applied to eliminate noise interference for the analysis of calcium carbonate (CaCO3), silicon dioxide (SiO2), aluminum oxide (Al2O3), and ferric oxide (Fe2O3) in cement raw materials. Different wavelength selection techniques are used to perform a comprehensive analysis of the model, comparing the performance of several wavelength selection techniques. The back-propagation neural network regression model based on particle swarm optimization algorithm was also applied to optimize the extracted and screened feature wavelengths, and the model prediction performance was checked and evaluated using Rp and RMSE. In conclusion, the results indicate that NIR spectroscopy in combination with ML and chemometrics has great potential to effectively improve the prediction performance of oxide content in raw materials and highlight the importance of modeling and wavelength selection techniques. By enabling more accurate and efficient determination of oxide content in raw materials, NIR spectroscopy coupled with meta-modeling has the potential to revolutionize quality assurance practices in cement manufacturing.
Reliability on the Internet of Things with designing approach for exploratory analysis
Authors: Singh Khushwant , Yadav Mohit , Singh Yudhvir , Barak Dheerdhwaj , Saini Ashish , Moreira Fernando
Published: June 2024

The Internet of Things (IoT) proposes to transform human civilization so that it is smart, practical, and highly efficient, with enormous potential for commercial as well as social and environmental advantages. Reliability is one of the major problems that must be resolved to enable this revolutionary change. The reliability issues raised with specific supporting technologies for each tier according to the layered IoT reliability are initially described in this research. The research then offers a complete review and assessment of IoT reliability. In this paper, various types of reliability on the IoT have been analyzed with each layer of IoT to solve the issues of failure rates, latency, MTTF, and MTBF. Each parameter has a certain classification and perception as well as enhancement in efficiency, accuracy, precision, timeliness, and completeness. Reliability models provide efficient solutions for different IoT problems, which are mirrored in the proposed study and classified with four types of reliabilities. The field of IoT reliability exploration is still in its initial phases, despite a sizable research record. Furthermore, the recent case study of CHISS is elaborated with discovered behaviors including brand-new aspects such as the multifaceted nature of evolving IoT systems, research opportunities, and difficulties.
Epigenetic modifications in abdominal aortic aneurysms: from basic to clinical
Authors: Liu YuChen , Sun XiaoYun , Gou Zhen , Deng ZhenKun , Zhang YunRui , Zhao PingPing , Sun Wei , Bai Yang , Jing YuChen
Published: June 2024

Abdominal Aortic Aneurysm (AAA) is a disease characterized by localized dilation of the abdominal aorta, involving multiple factors in its occurrence and development, ultimately leading to vessel rupture and severe bleeding. AAA has a high mortality rate, and there is a lack of targeted therapeutic drugs. Epigenetic regulation plays a crucial role in AAA, and the treatment of AAA in the epigenetic field may involve a series of related genes and pathways. Abnormal expression of these genes may be a key factor in the occurrence of the disease and could potentially serve as promising therapeutic targets. Understanding the epigenetic regulation of AAA is of significant importance in revealing the mechanisms underlying the disease and identifying new therapeutic targets. This knowledge can contribute to offering AAA patients better clinical treatment options beyond surgery. This review systematically explores various aspects of epigenetic regulation in AAA, including DNA methylation, histone modification, non-coding RNA, and RNA modification. The analysis of the roles of these regulatory mechanisms, along with the identification of relevant genes and pathways associated with AAA, is discussed comprehensively. Additionally, a comprehensive discussion is provided on existing treatment strategies and prospects for epigenetics-based treatments, offering insights for future clinical interventions.
Comparative analysis through propensity score matching in thyroid cancer: unveiling the impact of multiple malignancies
Authors: Al-Ibraheem Akram , Abdlkadir Ahmed Saad , Al-Adhami Dhuha Ali , Lopci Egesta , Al-Omari Amal , Al-Masri Mahmoud , Yousef Yacoub , Al-Hajaj Nabeela , Mohamad Issa , Singer Susanne , Sykiotis Gerasimos P.
Published: June 2024

Background

The incidence of thyroid cancer is on the rise worldwide, with childhood exposure to radiation being the sole acknowledged catalyst for its emergence. Nonetheless, numerous other factors that may pose risks are awaiting thorough examination and validation. This retrospective study aims to explore the malignancies linked to thyroid cancer and contrast the survival rates of those afflicted with a solitary tumor versus those with multiple primary neoplasms (MPN).

Methods

This retrospective study examined data from King Hussein Cancer Center (KHCC), Jordan. Among 563 patients diagnosed with thyroid cancer, 30 patients had thyroid malignancy as part of MPN. For a 1:3 propensity score-matched analysis, 90 patients with only a primary thyroid malignancy were also enrolled.

Results

Hematologic and breast malignancies were among the most frequent observed cancers alongside thyroid neoplasm. Patients who had MPN were diagnosed at older age, had higher body mass index and presented with higher thyroglobulin antibody levels (p < 0.05 for each). Additionally, MPN patient displayed a stronger family history for cancers (p= 0.002). A median follow-up duration of 135 months unveiled that MPN patients faced a worse 5-year survival compared to their counterparts with a singular neoplasm (87% vs 100% respectively; p < 0.01). However, no distinction emerged in the 5-year event-free survival between these two groups.

Conclusion

MPN correlates with a significantly altered survival outcome of thyroid cancer patients. The diagnosis of thyroid carcinoma at an older age, accompanied by elevated initial thyroglobulin antibody levels and a notable familial predisposition, may raise concerns about the potential occurrence of synchronous or metachronous tumors.
Unveiling immune tolerance pathways in preeclampsia placenta: implications for molecular targets and discovery of potential biomarkers
Authors: Ma Yantuanjin , Deng Xingli , Shen Ru , Zhang Hongqing , Qian Yuan
Published: June 2024

During pregnancy, there is a link between disruption of maternal immune tolerance and preeclampsia, but the molecular mechanisms that regulate maternal and fetal immune tolerance remain unclear. This study employs bioinformatics to identify new markers related to placental immune tolerance and explore their potential role in predicting preeclampsia. Analyzing preeclampsia-related gene expression profiles in the Gene Expression Omnibus (GEO) dataset reveals 211 differentially expressed genes (DEGs) in the placenta, mainly influencing immune cell differentiation and response pathways. Employing weighted gene co-expression network analysis (WGCNA) and lasso regression, four potential target genes (ANKRD37, CRH, LEP, SIGLEC6) are identified for potential prediction of preeclampsia. Validation using the GSE4707 dataset confirmed the diagnostic and predictive potential of these candidate genes. RT-qPCR verified up-regulation in the placenta, while ELISA showed their correlation with immune tolerance factors associated with placental immune tolerance. As a result of this study, identifies potential biomarkers associated with placental immunity and contributes to understanding the molecular mechanism of preeclampsia.
Preparation and electrochemical properties of Li6La3Zr0.7Ti0.3Ta0.5Sb0.5O12 high-entropy Li-garnet solid electrolyte
Authors: Ye Ruijie , Ting Yin-Ying , Dashjav Enkhtsetseg , Ma Qianli , Taminato Sou , Mori Daisuke , Imanishi Nobuyuki , Kowalski Piotr M. , Eikerling Michael H. , Kaghazchi Payam , Finsterbusch Martin , Guillon Olivier
Published: June 2024

Garnet-type solid electrolytes stand out as promising Li-ion conductors for the next-generation batteries. It has been demonstrated that the inherent properties of garnets can be tailored by introducing various dopants into their crystal structures. Recently, there has been a growing interest in the concept of high entropy stabilization for materials design. In this study, we synthesized high-entropy garnets denoted as Li6La3Zr0.7Ti0.3Ta0.5Sb0.5O12 (LLZTTSO), wherein Ti, Sb, and Ta occupy the Zr site. The formation of the cubic garnet phase in LLZTTSO was confirmed through X-ray diffraction (XRD), and the resulting lattice parameter agreed with predictions made using computational methods. Despite the substantial porosity (relative density 80.6%) attributed to the low sintering temperature, LLZTTSO exhibits a bulk ionic conductivity of 0.099 mS cm−1 at 25°C, and a total ionic conductivity of 0.088 mS cm−1, accompanied by an activation energy of 0.497 eV. Furthermore, LLZTTSO demonstrates a critical current density of 0.275 mA cm−2 at 25°C, showcasing its potential even without any interfacial modification.
The influence of agricultural insurance on agricultural carbon emissions: evidence from China’s crop and livestock sectors
Authors: Jin Yue , Wang Xinya , Wang Qian
Published: June 2024

Agricultural insurance is an important tool for promoting low-carbon agriculture and achieving the “Carbon Peaking and Neutrality” goal. Using panel data from 31 provinces in China from 2001 to 2020, this study analyzes the carbon-reducing effects of agricultural insurance in both crop and livestock sectors. The results show that: (1) Agricultural insurance can decrease agricultural carbon emissions. (2) For crops, agricultural insurance reduces carbon emissions through green technical efficiency, and for livestock products by green technological advances. (3) Agricultural insurance could lower carbon emissions from the livestock and crop sectors in the eastern region. The carbon-reducing benefits of agricultural insurance for the crop sector are seen in the agricultural, agro-pastoral, and pastoral domains; for the livestock sector, these impacts are only seen in the agricultural domains.
Response of the functional traits of Schoenoplectus tabernaemontani to simulated warming in the Napahai wetland of northwestern Yunnan, China
Authors: Liu Zhenya , Zhao Yiqing , Yu Hongyan , Zhao Yao , Guo Huijun , Sun Mei
Published: June 2024

The impact of climate warming on wetland ecosystems is a current focal point in ecological research. In this study, the Napahai wetland, a typical plateau wetland in northwest Yunnan Province, was selected as the study site to understand the growth and survival strategies of emergent plants in a plateau wetland under climate warming conditions. Open-top chambers (OTCs) were used to simulate warming in three treatments (i.e., control group, 2.0 ± 0.5°C, and 4.0 ± 0.5°C) in order to study the responses of the functional traits of the dominant emergent plant Schoenoplectus tabernaemontani to simulated warming. The results showed that simulated warming significantly reduced the photosynthetic carbon assimilation capacity and biomass accumulation of S. tabernaemontani, as well as its nitrogen content and vascular bundle density, while it significantly increased the vascular bundle size. The growing season accumulated temperature (AT) and the mean temperature of the hottest month (WT) were the main temperature factors influencing the functional traits of S. tabernaemontani. In summary, simulated warming significantly affected the functional traits of S. tabernaemontani, which demonstrated effective adaptation to warming conditions. As the temperature rises and the light and productivity decrease, S. tabernaemontani prioritizes the supply of limited resources to the underground part to ensure the biomass supply of the reproductive structure. This study provides a case for revealing the response patterns and ecological adaptation strategies of plateau wetland plants to climate warming.
ScnML models single-cell transcriptome to predict spinal cord neuronal cell status
Authors: Liu Lijia , Huang Yuxuan , Zheng Yuan , Liao Yihan , Ma Siyuan , Wang Qian
Published: June 2024

Injuries to the spinal cord nervous system often result in permanent loss of sensory, motor, and autonomic functions. Accurately identifying the cellular state of spinal cord nerves is extremely important and could facilitate the development of new therapeutic and rehabilitative strategies. Existing experimental techniques for identifying the development of spinal cord nerves are both labor-intensive and costly. In this study, we developed a machine learning predictor, ScnML, for predicting subpopulations of spinal cord nerve cells as well as identifying marker genes. The prediction performance of ScnML was evaluated on the training dataset with an accuracy of 94.33%. Based on XGBoost, ScnML on the test dataset achieved 94.08% 94.24%, 94.26%, and 94.24% accuracies with precision, recall, and F1-measure scores, respectively. Importantly, ScnML identified new significant genes through model interpretation and biological landscape analysis. ScnML can be a powerful tool for predicting the status of spinal cord neuronal cells, revealing potential specific biomarkers quickly and efficiently, and providing crucial insights for precision medicine and rehabilitation recovery.
Routine antenatal molecular testing for α-thalassemia at a tertiary referral hospital in China: ten years of experience
Authors: Li Dongming , Liang Lifang , Meng Dahua , He Sheng
Published: June 2024

Objective

This study aimed to evaluate the efficacy of α-thalassemia gene testing as a part of an antenatal intervention program over a 10-year period.

Methods

All patients underwent α-thalassemia gene testing, which included the analysis of three types of deletions and mutations. Rare α-thalassemia gene testing was performed using Sanger sequencing, multiplex ligation-dependent probe amplification, and sequencing techniques. Prenatal diagnosis was performed in high-risk couples using chorionic villus sampling or amniocentesis.

Results

From 2010 to 2019, among the 91,852 patients examined, α-thalassemia mutations were identified in 41.78% of patients. The most frequent α0 gene mutation was--SEA, followed by--THAI. Two rare α0-thalassemia gene mutations at --32.8 and --230, were also observed. A total of 2,235 high-risk couples were identified, of which 562 were affected, including three with the--SEA/--THAI genotype and one with the--SEA/--230 genotype. Additionally, prenatal diagnosis revealed four cases of fetal anemia and/or mild edema, along with two cases of severe fetal edema. Chromosome and gene chip results were normal. Thalassemia gene testing showed an αCSα/αCSα genotype in four patients with anemia and/or mild edema, while two patients with severe fetal edema had one--SEA/αCSα genotype and one--SEA/--GX genotype. Using the cut-off points of 74.6 fL and 24.4 pg as criteria for identifying α0-thalassemia carriers and HbH disease, the detection rate of missed diagnoses in high-risk couples is consistent with national guidelines for standards, potentially saving 10,217,700 ¥.

Conclusion

Routine molecular testing for α-thalassemia in high-risk prenatal populations effectively prevented severe α-thalassemia births. Despite the high cost, the cutoff points proposed by this study suggest that implementing screening using a new parameter has the potential to reduce current expenses.
Efficacy of steroid therapy in the acute stage of anti-NMDAR and anti-MOG antibody overlapping encephalitis: a case report and literature review
Authors: Kondo Hikari , Takeuchi Yuko , Niwa Junichi , Yoshida Kenji , Takemura Naoaki , Hosoyama Sachiko , Kaga Tomotsugu , Kaneko Kimihiko , Mabuchi Naoki
Published: June 2024

Background

Recently, cases of overlapping encephalitis caused by anti-N-methyl-D-aspartate receptor (anti-NMDAR) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have been reported, and their clinical characteristics are gradually becoming clear. Acute-phase treatment typically involves the use of steroids, and although some studies have suggested that steroids can be effective, the extent of their efficacy has not yet been fully explored.

Case presentation

We present the case of a 25-year-old man with anti-NMDAR and anti-MOG antibody overlapping encephalitis who showed considerable improvement after steroid treatment. To gain a deeper understanding of the efficacy of steroids in managing this condition, we conducted a literature review of cases of anti-NMDAR and anti-MOG antibody double-positive encephalitis that were treated with steroids during the acute phase. Thirteen cases were analyzed, including a new case diagnosed at our hospital. All patients showed improvement after receiving steroid treatment in the acute phase. Ten patients did not have any sequelae, and nine of them showed a rapid or major response during the acute phase. In contrast, three patients experienced sequelae (mild cognitive decline, visual impairment, and memory impairment, respectively), with their response to steroids in the acute phase being slow or limited. Relapses occurred in five patients, in one patient during steroid tapering, and in another two patients after cessation of steroids.

Conclusion

Steroid therapy can be effective in the acute stage of anti-NMDAR and anti-MOG antibody overlapping encephalitis. A positive prognosis may be expected in patients who experience substantial improvement with steroid therapy during the acute phase.
Succession of phytoplankton communities from macro-scale to micro-scale in coastal waters of Qinhuangdao, China
Authors: Shang Xiaomei , Yang Shuang , Sun Jun
Published: June 2024

The coastal area of Qinhuangdao, particularly the Changli Gold Coast Nature Reserve, is experiencing ecological degradation and frequent Harmful Algal Blooms (HABs). This study focuses on the changing phytoplankton communities in these coastal waters, examining them from both a macroscopic and microscopic perspective. Utilizing microscopy, molecular techniques, and pigment analysis, seasonal shifts were observed, with diatoms predominating in June and July, and dinoflagellates in August. Our morphological examination enabled the classification of 89 species into four distinct groups. The species Paralia sulcata and Pseudo-nitzschia pungens were most abundant in early summer, while Tripos furca, a dinoflagellate, dominated in August. This indicates a shift in phytoplankton communities due to environmental factors such as phosphate deficiency and high nitrogen/phosphorus ratios. Additionally, the study notes the impact of reduced river runoff and reintroduction of scallop farming contributing to nitrogen-rich eutrophication in August. Molecular analysis revealed a disparity between microscopic observations and the prevalence of Teleaulax blooms during early summer. Elevated concentrations of TN and DOC, coupled with limited water exchange, emerged as primary factors contributing to their occurrence. Sediment analysis revealed a high diversity but low abundance of dinoflagellates in August, with a significant presence of harmful species. The study highlights the shift from diatoms to harmful dinoflagellate populations, exacerbated by eutrophication and pollution, leading to HABs. These findings provide a theoretical basis for understanding toxic algal blooms and are crucial for environmental agencies in developing strategies to protect and sustainably develop offshore environments.
Explanations for the positive storm surges on the left side of landfall typhoons in China
Authors: Wan Weiqi , Feng Xingru , Yin Baoshu , Liu Qingrong
Published: June 2024

The coastal regions of Southeast China frequently experience unusual positive storm surges on the left side of landfalling typhoons, a phenomenon historically overlooked and inadequately explained by conventional circular wind field models. In this study, a high resolution, two-dimensional storm surge model based on ADCIRC along with tide gauge data were used to investigate the spatiotemporal distribution of these surges and proposes underlying mechanisms, informed by a comparative analysis of circular and ERA5 reanalysis wind fields during typical typhoon event 9711 Winnie. Analyzing tide gauge data spanning from 1986 to 2016, the study uncovers a distinct pattern of left-side positive storm surges along the southeastern coast, notably on the Fujian coast and within the Taiwan Strait, which are found to be comparable to those on the cyclone’s right side. The research also documents a significant escalation in both the frequency and intensity of these left-side surges over the past three decades. Simulation results highlights the inadequacies of circular wind field models in operational forecasting and emphasizes the necessity of accounting for topographic influences and the structural complexity of wind fields in storm surge predictions. This is particularly pertinent in semi-enclosed seas with intricate hydrodynamics, such as the Taiwan Strait. The insights gleaned from this study are pivotal for enhancing the real-time simulation and prediction of storm surges, which are vital for coastal safety and disaster prevention measures.
Investigating the synergistic anti-aging effects of Sasobit and recycled engine oil in styrene-butadiene rubber modified asphalt
Authors: Li Zhen , Lu Zhen , Liu Xiajun , Wang Jianxiang
Published: June 2024

During the preparation of asphalt mixtures, styrene-butadiene rubber (SBR) polymers are susceptible to thermal decomposition, which can significantly impair the binder’s low-temperature performance. This study explores the potential of combining warming agents with waste materials to enhance the low-temperature properties and aging resistance of the binder. Specifically, it examines the synergistic impact of Sasobit/recycled engine oil (Sasobit/REO) composites on the rheological and physical attributes of styrene-butadiene rubber asphalt binder (SBRAB). Utilizing fluorescence microscopy (FM), bending beam rheometer (BBR), and dynamic shear rheometer (DSR), the study assesses the aging resistance and modification mechanisms of Sasobit/REO on SBRAB. The findings indicate that the incorporation of Sasobit/REO composites more effectively reduces the mix preparation temperature than either component alone. The preparation of Sasobit/REO warm mix asphalt mixtures is feasible at temperatures 20°C lower than those required for traditional hot mixtures. These composites also enhance the performance of SBRAB at both high and low temperatures, counteracting the adverse effects associated with the individual use of Sasobit or REO. This reduced short-term aging temperature is beneficial in lessening the negative impact of high temperatures on SBRAB’s performance. Moreover, the addition of Sasobit/REO composites significantly improves the thermal cracking resistance of SBRAB mixtures. The study also demonstrates that Sasobit/REO enhances the short-term and long-term aging resistance of SBRAB, paving the way for the broader application of this novel warm mix additive in the asphalt industry.
No association between hepatitis C virus infection and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies
Authors: Chang Cheng , Yan Hong-Mei , Liao Yan-Lin
Published: June 2024

Background and aim

There is still uncertainty regarding whether hepatitis C virus (HCV) infection is associated with colorectal cancer (CRC). This study aims to investigate the potential association between HCV infection and CRC through a systematic review and meta-analysis of cohort studies.

Methods

PubMed, Embase, and Web of Science were systematically searched from the beginning of their inception to October 2023 to find relevant cohort studies on the association between HCV infection and CRC risk. The random-effect, generic inverse variance method was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC outcome among individuals with HCV infection. We also performed subgroup and sensitivity analysis.

Results

A total of 8 cohort studies involving 1,939,164 participants were included in this meta-analysis. The result from the meta-analysis suggested that there was no statistically significant association between HCV and the risk of developing CRC (HR = 0.99, 95% CI: 0.82–1.88, p = 0.88) with low statistical heterogeneity (I2 = 28%, p = 0.20). Subgroup analyses that were conducted based on study design, diagnosis of HCV infection, and publication year yielded similar results. Analyses of subgroups based on study areas revealed that there was no significant association between HCV infection and CRC risk in Asia (n = 2, HR = 0.96, 95% CI: 0.71–1.29, p = 0.79; I2 = 26%), Europe (n = 3, HR = 1.06, 95% CI: 0.83–1.37, p = 0.63; I2 = 0%), and North America (n = 2, HR = 1.10, 95% CI: 0.87–1.38, p = 0.44; I2 = 0%); however, a negative correlation was found in Oceania (n = 1, HR = 0.43, 95% CI: 0.22–0.84, p = 0.01). Sensitivity analysis further reinforce the stability of our conclusion.

Conclusion

Our cohort-based meta-analysis showed insufficient evidence to support the association between HCV infection and an increased risk of CRC. To gain a clearer insight into the potential association between these two conditions, it would be beneficial to conduct large, well-designed, high-quality prospective cohort studies that consider different ethnic populations and potential confounding factors.

Systematic review registration: PROSPERO, identifier [CRD42023472688], https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023472688.