bluuebunny/crossref_metadata_2025 huggingface dataset:
Derecho Administrativo e interdisciplinariedad
Authors: Rincón Córdoba Jorge Iván
Published: November 2023

En el presente el Derecho administrativo debe posibilitar la realización de estudiosinterdisciplinarios, no como un único recurso metodológico sino como una alternativa enaquellos supuestos en los que las problemáticas analizadas demandan, tanto del docentecomo del estudiante, el análisis de factores extrajurídicos para comprender no sólo elcontexto de una determinada situación o institución, sino para construir nuevoconocimiento o, cuando menos, enriquecer el ya creado.
La docencia de Derecho Constitucional de personas con necesidades educativas especiales en la Universidad: una visión personal desde la perspectiva del docente.
Authors: García Gestoso Noemi
Published: November 2023

El objeto de esta contribución es exponer mi experiencia como profesora universitaria alimpartir materias del ámbito de Derecho Constitucional a alumnos que presentan opresentaban algún tipo de discapacidad de la que deriva algunas necesidades educativasespeciales en la Universidad de Vigo y mis reflexiones personales a la luz de estaexperiencia. Además expondré el sistema previsto en esta Universidad para la atenciónde estos alumnos.
Universidad y discapacidad. Diagnóstico sobre la inclusión de estudiantes con discapacidad en la Universidad de Córdoba.
Authors: García-Cano Torrico María , Castillejo Arroyo Ana , Jiménez Luque Natalia , Martínez Gallego Irene , Chiara María , Alós Cívico Francisco
Published: November 2023

El artículo presenta los resultados obtenidos en el primer estudio realizado por laUniversidad de Córdoba, a través del Servicio de Atención a la Diversidad, sobre lainclusión de las personas con discapacidad en la comunidad universitaria. En el estudioparticiparon 81 estudiantes con discapacidad matriculados en la Universidad durante elcurso académico 2016/17. Los participantes cumplimentaron el cuestionario (Cunidis-d),el cual recaba básicamente información sobre: adaptaciones curriculares, acción docente,accesibilidad y comunidad universitaria. La presente investigación recoge informaciónvaliosa a dos niveles: 1. Características descriptivas de la muestra de estudiantes condiscapacidad de la UCO. 2. Tabulación de las opiniones dadas respecto a los grupostemáticos recogidos en el cuestionario.
Derechos y canciones fundamentales: una aproximación musical al estudio de los derechos fundamentales. Fundamental rights and songs: a musical approach to the study of fundamental rights
Authors: Pérez Domínguez Fernando
Published: November 2023

La presente comunicación trata de exponer los motivos justificativos, losobjetivos, la metodología, el plan de ejecución y los resultados que viene produciendo elProyecto de Innovación Docente titulado “Derechos y Canciones Fundamentales”, que seha desarrollado a lo largo del curso 2017/18 desde la Universidad de Huelva. EsteProyecto presta atención a la riqueza de reflexiones, debates y situaciones que tienen porobjeto y referencia a los Derechos Fundamentales y que se manifiestan con intensidad enexpresiones artísticas como la música. Recopilar y sistematizar ese material musical através de una metodología de trabajo colaborativo es lo que pretende este Proyecto, conel objeto de ofrecer a los alumnos de Derecho una nueva y atractiva forma de aproximarseal estudio jurisprudencial de los Derechos Fundamentales, y al resto de ciudadanos unmotivo para promocionar la cultura de los Derechos.
La futura e hipotética asignatura de Justicia Restaurativa. Guía docente y pasos a seguir
Authors: Miguel Barrio Rodrigo
Published: November 2023

Ante el impulso que la justicia Restaurativa está adquiriendo tanto a nivelesdoctrinales como prácticos, se hace necesario su implantación como asignatura delGrado en Derecho, fomentando así entre el alumnado el conocimiento de lasposibles vías de resolución pacífica de conflictos entre los ciudadanos. Se va apromover un estudio doctrinal y pragmático a través del uso de métodos como mootcours, case method y la visualización de series y películas de ficción para ofrecerun conocimiento y una visión actual de las instituciones.
La internacionalización de la educación superior y la cooperación interuniversitaria como motor de cohesión social y desarrollo sostenible.
Authors: Montesinos Padilla Carmen
Published: November 2023

Su progresiva internacionalización y el refuerzo del enfoque basado encompetencias, han hecho proliferar las críticas frente a un sistema de EducaciónSuperior que se considera cada vez más mercantilizado. Sin embargo, a través delpresente trabajo se pretende defender una todavía muy necesaria cooperacióninternacional entre instituciones educativas radicadas en Estados con distinto nivelde desarrollo. Los argumentos teóricos a tales efectos presentados se acompañaránde un ejemplo de cooperación a través de una red de universidades de caráctertransformacional.
La simulación de un juicio con carácter interdisciplinar como experiencia docente en tiempos de pandemia
Authors: Martín Fernández Carmen , Urbano Sánchez Lucía
Published: November 2023

«La simulación de un juicio (moot court) con carácter interdisciplinar comoexperiencia docente» es un proyecto de innovación docente que se enmarca en elseno de un programa de formación del profesorado novel de la Universidad deCórdoba. Este proyecto tiene por objeto la realización de una simulación judicialpor equipos que persigue, fundamentalmente, la transferencia del conocimientoteórico a la práctica, mediante el planteamiento de un problema jurídico de caráctermultidisciplinar al que el alumnado ha de dar solución, desde dos perspectivasdistintas: la de la parte demandante y la de la parte demandada. Concretamente, elpresente trabajo pretende exponer el desarrollo de esta actividad, así comocompartir los resultados alcanzados con la misma y los principales inconvenientesdetectados tras su ejecución, a fin de que dicho análisis pueda traducirse en laimplementación de mejoras con vistas a futuras ediciones de esta actividad.
Un enfoque multidisciplinar en la docencia del Derecho: Reflexiones desde la experiencia de un proyecto de innovación docente basado en el método del caso
Authors: Jiménez Pineda Eduardo , González Jiménez Pedro Mario
Published: November 2023

Este artículo trata de poner de manifiesto las virtudes de una aproximaciónmultidisciplinar en la docencia del Derecho a partir de la experiencia desarrolladacon ocasión de un proyecto de innovación docente, con carácter interdisciplinar,basado en el método del caso. Así, se expone el modo en que se ha incorporado lamultidisciplinariedad a una simulación judicial, mediante la intervención de cuatroáreas de conocimiento, que han impartido formaciones específicas en cuartodisciplinas jurídicas, con objeto de capacitar al alumnado participante con losconocimientos necesarios para la resolución global del caso y el consiguienteaprendizaje jurídico desde una perspectiva multidisciplinar y eminentementepráctica. En fin, se concluyen los aspectos positivos de este tipo de enfoque de ladocencia del Derecho
Adaptación al entorno digital de la docencia de una asignatura multidisciplinar del Máster de acceso a la Abogacía: aplicación y protección de los Derechos Fundamentales
Authors: Simancas Sánchez Daniel
Published: November 2023

El presente artículo tiene como objetivo dar a conocer el proyecto deinnovación docente desarrollado por un grupo de docentes de la Facultad de Derecho de la Universidad Complutense de Madrid. Este proyecto perseguía adaptar una asignatura multidisciplinar del Máster de Acceso a la Abogacía a las nuevas herramientas al denominado “entorno digital”. La lectura del este artículo permitirá, por tanto, conocer los objetivos, la metodología, las diversas actividadesrealizadas durante proyecto y, por último, en los resultados obtenidos en el mismo.
EXPERIENCIAS DE APRENDIZAJE DEL DERECHO MERCANTIL A TRAVÉS DE LA JURISPRUDENCIA
Authors: Hernández Sainz Esther
Published: November 2023

El objeto de este trabajo es exponer nuestra experiencia en el diseño y puesta en práctica de actividades de aprendizaje a través de la jurisprudencia en las asignaturas Derecho Mercantil II y Derecho de Sociedades y del mercado de valores. Se explicará el proceso de preparación de las actividades, su desarrollo y los resultados de aprendizaje obtenidos por los alumnos. Finalmente se incluye una revisión de los beneficios que reporta esta metodología para la enseñanza del Derecho mercantil y para adecuarse al contexto de aprendizaje de competencias y habilidades que demandan los nuevos Planes de estudios en el marco del Espacio Europeo de Educación Superior; así como de las dificultades de su puesta en práctica.
EDITORIAL
Authors: Izquierdo Carrasco Manuel
Published: November 2023

En vuestras pantallas se presenta un nuevo número de Docencia y Derecho. La austeridad presupuestaria que nos envuelve también se ha manifestado en la ayuda que la Universidad de Córdoba, dentro de su Plan de Innovación y Mejora Educativa, nos viene concediendo en los últimos años, pero aquí estamos de nuevo. Y volvemos incluso con energías renovadas pues en este año se nos ha brindado la oportunidad de participar, junto con otras revistas on line de temática próxima, en una mesa redonda en el V Congreso Nacional de Docencia en Ciencias Jurídicas, celebrado recientemente en Valencia, y donde llegamos a unas conclusiones muy enriquecedoras. Las actas pueden consultarse en la siguiente dirección electrónica: www.uv.es/innodret/pub/2013actas_congreso.pdf
UNA PROPUESTA DIDÁCTICA A LA LUZ DEL COACHING: ENSEÑANDO UNA PERSPECTIVA DE GÉNERO SOBRE LOS DERECHOS HUMANOS
Authors: Urquizú Serrano Ana María , Valencia Ruiz Juliana , Castro Notario Francisca , Sanchís Vidal Amelia , Izquierdo Carrasco Manuel
Published: November 2023

Sensibilizar y formar al alumnado en la aportación de las mujeres en la construcción de los Derechos Humanos.
La evaluación por competencias de los casos prácticos sobre Derechos Fundamentales
Authors: Pérez Alberdi María Reyes José
Published: November 2023

En este trabajo, exponemos una experiencia docente de evaluación de los casos prácticos sobre derechos fundamentales a través de diversas herramientas que permiten objetivar esta tarea mediante la parcelación de la actividad en pequeñas unidades de observación y con referencia a cada una de las competencias trabajadas como son las rúbricas, escalas de valoración, listas de control, etc. A través de ello, se consigue no sólo dar publicidad a los criterios de evaluación y asegurar la transparencia del proceso, sino además proporcionar al alumnado una guía útil que le permite conocer cuál es su progreso y mejorar en su avance, convirtiéndose así en un elemento esencial del proceso formativo del estudiante.
Editorial
Authors: Queralt Jiménez Argelia
Published: November 2023

Este monográfico de la Revista Docencia y Derecho es, en su mayor parte, el resultado del seminario “El Trabajo de fin de grado a examen” que se celebró en Zaragoza el pasado 19 de febrero, bajo el paraguas de XIII Congreso de la Asociación de Constitucionalistas de España (ACE).
La evaluación de los trabajos fin de grado en la Facultad de Derecho de la Universidad de Zaragoza
Authors: Cebrián Zazurca Enrique
Published: November 2023

Este artículo pretende repasar y presentar al lector interesado la corta experiencia deevaluación de Trabajos Fin de Grado en la Facultad de Derecho de la Universidad deZaragoza, siguiendo el curso de la normativa destinada a evaluar esos Trabajos vigenteen cada momento, relatando alguno de sus efectos a la hora de su puesta en práctica yplanteándose una serie de dudas e inquietudes en torno al método mejor de evaluacióndel Trabajo Fin de Grado. Asimismo, ello se verá complementado por lo recogido en laGuía Docente de la asignatura “Trabajo Fin de Grado”, con el fin de mostrar de maneramás ajustada los criterios existentes en la evaluación del TFG.
The importance of Environmental Product Declarations in the decarbonization effort
Authors: Fuhler Megan , Panozzo Brent , Dodd Birgitte , Pasley Dylan , Young Allison
Published: November 2023

An Environmental Product Declaration (EPD) is a disclosure document that communicates how a product or material affects the environment throughout its life cycle. EPDs are used across many industries and government organizations as an accurate source of information when making procurement decisions to minimize environmental impacts. Developed by businesses and certified by third-party organizations, EPDs are created to communicate the environmental impacts of specified life-cycle stages of a product. As such, EPDs can be an important tool for organizations working toward carbon reduction goals, such as the Army’s decarbonization goals of Executive Order (EO) 14,057 and the Army Climate Strategy. This document summarizes the current state of EPDs, including how they are created, how they can be used to help analyze the environmental impacts of construction materials, and how they are being used by government entities. Also discussed are other decarbonization tools and methods to integrate EPDs, providing a more wholistic approach to the construction industry’s activities and impacts. The document concludes with a discussion of the challenges and the future of EPDs.
Analysis of chlorophyll and carotenoid compounds in eucalyptus leaves
Authors: Younes Nicolas , Cain Sophia
Published: November 2023

This protocol aims to extract and measure the amount of chlorophyll and carotenoids in leaf material using spectrophotometry. An ethanol extraction is used to analyse both chlorophyll a and b and carotenoids in leaf material with compounds quantified using absorbance across a range of wavelengths. This protocol uses ethanol as the extracting solution due to its affordability and safety compared to other reagents. We report a methodology that extracts pigments from whole leaf discs. The combination of extraction from leaf discs and ethanol extraction ensures this protocol is safe and rapid to complete. The protocol includes three phases: a preparation phase where samples are punched and added to ethanol (approximately 3 hours for 100 samples), an extraction phase where samples are left overnight, and a measurement phase where absorbance at a range of wavelengths is recorded using spectrophotometry (approximately 1 hour for 100 samples).
Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors
Authors: Beavis Paul , Darcy Phillip , Lai Junyun , Chan Jack , Sek Kevin , Scheffler Christina , Munoz Isabelle , Huang Yu-Kuan , Yap Kah Min , Lee Joel , Li Jasmine , Chen Amanda , Chan Cheok Weng , Derrick Emily , Todd Kirsten , Tong Junming , de Menezes Maria N. , Petley Emma , Kim Joelle , Nguyen Dat , Leung Patrick , So Joan , Deguit Christian Deo , Zhu Joe , House Imran , Kats Lev , Oliaro Jane , Parish Ian , Quinn Kylie , Neeson Paul , Slaney Clare , Saw Nicole , Dunbar Phoebe , Li Jiawen , Hoang Thang , Solomon Benjamin , Harrison Simon , Scott Andrew
Published: November 2023

The efficacy of chimeric antigen receptor (CAR) T cell therapy is limited in solid tumors by several factors including the immunosuppressive tumor microenvironment that gives rise to poorly persisting and metabolically dysfunctional T cells. To overcome this, we sought to identify transcription factors that could enhance CAR T cell fitness. We identified that the overexpression of Foxo1 could enhance the therapeutic efficacy of murine CAR T cells in the setting of syngeneic immunocompetent models and was dependent on the sustained production of proinflammatory cytokines. FOXO1 overexpression in human CAR T cells enforced broad transcriptional and epigenetic changes that led to a more “stem-like” phenotype and similarly improved therapeutic efficacy. Enhanced efficacy was associated with improved mitochondrial fitness and persistence in vivo. FOXO1 overexpression also led to a more stem like phenotype in patient derived CAR T cells and is therefore a promising strategy for the treatment of solid cancers.
Bacterial volatile organic compounds from Bacillus zanthoxyli HS-1 enhance tolerance responses against salt and high temperature in cucumber and cabbage
Authors: Barghi Anahita , Jung Ho Won
Published: November 2023

Background Abiotic stresses pose significant challenges to agriculture and food security. Recent research has explored innovative approaches to enhance plant tolerance against such stresses, including the use of plant-derived compounds and plant growth-promoting rhizobacteria (PGPR). Despite this effort, identifying and characterizing PGPR as biostimulants for triggering plant tolerance response is still valuable. This study delves into how Bacillus zanthoxyli HS1 (BzaHS1) and BzaHS1-derived volatile organic compounds (VOCs) conferred systemic tolerance in cabbage and cucumber plants against salt and heat stresses.
Results Both direct application of a BzaHS1 strain and indirect exposure to BzaHS1-derived VOCs promoted seedling growth of cabbage and cucumber plants under salt- and heat-stressed conditions. This induced systemic tolerance by BzaHS1 and BzaHS1-derived VOCs accompanied by increased callose deposition and narrow stomatal aperture against salt and heat stress, respectively. Reduced proline and malondialdehyde levels were observed in cabbage and cucumber plants treated with BzaHS1 and BzaHS1-derived VOCs, indicating that these plants were less sensitive to mock-treated plants. In addition, transcription of genes encoding superoxide dismutase, catalase, and heat shock protein 70 were increased in cabbage and cucumber plants treated with BzaHS1 and BzaHS1-VOCs.
Conclusion Overall, BzaHS1 and its bVOCs show potential for enhancing salt and heat stress tolerance in plants through modulation of stress-responsive pathways involved in osmotic stress responses, regulatory processes, and antioxidant machinery.
Loss of EIF4G2 Mediates Aggressiveness in Distinct Human Endometrial Cancer Subpopulations with Poor Survival Outcome in Patients
Authors: Kimchi Adi , Meril Sara , Avni Maya Muhlbauer , Lior Chen , Bahlsen Marcela , Olender Tsviya , Savidor Alon , Krausz Judit , Peled Hila Belhanes , Birisi Hila , David Nofar , Bialik Shani , Scherz-Shouval Ruth , David Yehuda Ben
Published: November 2023

The non-canonical translation initiation factor EIF4G2 plays essential roles in embryonic development and differentiation, and contributes to the cellular stress response via translation of selective mRNA cohorts. Currently there is limited and conflicting information regarding the potential involvement of EIF4G2 in cancer development and progression. Endometrial cancer (EC) is the most pervasive gynecological cancer in the developed world, with increasing incidence every year. High grade ECs are largely refractory to conventional treatments, presenting poor survival rates and lacking suitable prognostic markers. Here we assayed a cohort of 280 EC patients across different types, grades, and stages, and found that low EIF4G2 expression highly correlated with poor overall and recurrence free survival in Grade 2 EC patients, monitored over a period of up to 12 years. To establish a causative connection between low EIF4G2 expression and cancer progression, we analyzed in parallel two independent human EC cell lines and demonstrated that stable EIF4G2 knock-down resulted in increased resistance to conventional therapies. Depletion of EIF4G2 also increased the prevalence of molecular markers for aggressive cell subsets, and altered their transcriptional and proteomic landscapes. Prominent among the proteins with decreased abundance were Kinesin-1 motor proteins KIF5B and KLC1, 2, 3. Multiplexed imaging of the tumors from this EC patient cohort showed a correlation between decreased protein expression of either KIF5B or KLC1, and poor survival in patients of certain grades and stages. The findings herein reveal potential novel biomarkers for Grade 2 EC with potential ramifications for patient stratification and therapeutic interventions.
Characteristics of infections with ancestral, Beta and Delta variants of SARS-CoV-2 in the PHIRST- C community cohort study, South Africa, 2020-2021
Authors: Cohen Cheryl , Kleynhans Jackie , von Gottberg Anne , McMorrow Meredith , Wolter Nicole , Bhiman Jinal N. , Moyes Jocelyn , du Plessis Mignon , Carrim Maimuna , Buys Amelia , Kahn Kathleen , Tollman Stephen , Lebina Limakatso , Wafawanaka Floidy , Toit Jacques , Gómez-Olivé Francesc Xavier , Dawood Fatimah S. , Mkhencele Thulisa , Martinson Neil , Tempia Stefano
Published: November 2023

Background
Data on the characteristics of individuals with mild and asymptomatic infections with different SARS-CoV-2 variants are limited. We therefore compared the characteristics of individuals infected with ancestral, Beta and Delta SARS-CoV-2 variants in South Africa.
Methods
We conducted a prospective cohort study in a rural and an urban site during July 2020-August 2021. Mid-turbinate nasal swabs were collected twice-weekly from household members irrespective of symptoms and tested for SARS-CoV-2 using real-time reverse transcription polymerase chain reaction (rRT-PCR). Differences by variant were evaluated using multinomial regression.
Results
We included 1200 individuals from 222 households and 648 rRT-PCR-confirmed infection episodes (66, 10%ancestral, 260, 40% Beta, 322, 50%Delta). Symptomatic proportion was similar for ancestral (7, 11%), Beta (44, 17%), and Delta (46, 14%) infections (p=0.4). After accounting for previous infection, peak incidence shifted to younger age groups in successive waves (40-59 years ancestral, 19-39 years Beta, 13-18 years Delta). On multivariable analysis, compared to ancestral, Beta infection was more common in individuals aged 5-12 years (vs 19-39)(adjusted odds ratio (aOR) 2.6, 95% confidence interval (CI)1.1-6.6) and PCR cycle threshold (Ct) value <30 (vs >35)(aOR 3.2, 95%CI 1.3-7.9), while Delta was more common in individuals aged <5 (aOR 6.7, 95%CI1.4-31.2) and 5-12 years (aOR 6.6 95%CI2.6-16.7)(vs 19-39) and Ct value <30 (aOR 4.5, 95%CI 1.3-15.5) and 30-35 (aOR 6.0, 95%CI 2.3-15.7)(vs >35).
Conclusions
Consecutive SARS-CoV-2 waves with Beta and Delta variants were associated with a shift to younger individuals. Beta and Delta infections were associated with higher viral loads potentially increasing infectiousness.
Are 6 more accurate than 4? The delivery mode and its influence on postpartum depression and PTSD.
Authors: Beck-Hiestermann Franziska Marie Lea , Hartung Lisa Kathrin , Richert Nadine , Miethe Sandra , Wiegand-Grefe Silke
Published: November 2023

Background
Empirical evidence shows that 2–6% of all women develop post-traumatic stress disorder (PTSD) and about 10–15% postpartum depression (PPD) after childbirth. This study examines PTSD and PPD in the context of delivery mode, focusing 4 different caesarean section modes, elective primary (Grade 4), medically indicated primary (Grade 3), secondary from relative indication (Grade 2) and emergency secondary caesarean section (Grade 1), compared to vaginal and assisted vaginal delivery (AVD). The impact of the six subdivided delivery mode categories on the level of postpartum depression and PTSD will be investigated using common predictors (for postpartum depression psychological treatment before childbirth, Fear of childbirth, Planning of pregnancy, social support after childbirth and for PTSD psychological treatment before childbirth, fear of childbirth, induction of labor, birth debriefing and social support after childbirth).
Methods
Between four weeks and two years postpartum, 1223 women were surveyed once via an anonymous online questionnaire on demographic and gynecological data, type of delivery, PTSD (PCL-5) and PPD (EPDS).
Results
For both psychiatric disorders, ANOVA revealed significant differences between delivery mode and PPD and PTSD. With weak effects for PPD and medium to strong effects for PTSD. Post-hoc tests showed increased levels of postpartum depression for all caesarean section types compared to both vaginal delivery types. For PTSD, secondary relative indication (Grade 2), emergency secondary caesarean section (Grade 1) and assisted vaginal delivery (AVD) were associated with elevated levels of PTSD. Regression analysis revealed the delivery mode as a significant predictor of EPDS- (medium effect size) and PCL-5-Score (medium to high effect size).
Limitation:
Delivery was assumed to be the traumatic event; previous traumas were not recorded. The definition of the delivery mode was reported subjectively and not medically confirmed.
Conclusion
The study highlights the influence of delivery modes on the mental health of postpartum mothers: different modes influence different postpartum disorders in different ways. However, the definition of the delivery mode was only stated subjectively and not medically confirmed. Further research should investigate which aspects of the different delivery modes influence maternal mental health and how the perception of the birth may depend on a specific delivery mode.
Network Analysis and Molecular Mapping for Alzheimer’s Disease to Reveal the Drug Targets of Arbutin
Authors: Uvarajan Deenathayalan , Ravikumar Manish , Durairaj Brindha
Published: November 2023

Alzheimer's disease (AD) is a neurodegenerative disease that causes the degradation of brain cells. AD is the most common causative factor of dementia that leads to cognitive decline and loss of independence. Cholinesterase inhibitors and N-methyl-D- aspartate (NMDA) antagonists are currently available drugs to treat AD related symptoms. Several studies have proved that arbutin is found to be beneficial in treating various diseases thereby modulating its brain targets which further helps to reduce AD’s side effects. The present research is mainly focused to study the molecular pathways and to determine the mechanism of action of arbutin to mitigate AD using a system pharmacology approach. Bioinformatics tools are explored to identify arbutin's therapeutic targets for AD, including Cytoscape for network analysis, ShinyGo for gene ontology enrichment, and AutoDock for docking molecules. In a Cytoscape network, the Maximal Clique Centrality (MCC) algorithm of the CytoHubba plugin was used to determine the top ten hub genes. Out of 411 targets for arbutin and 395 targets for AD, 37 targets were selected and shared through the data filtering process. The biological activities of these 37 genes include post-translational regulation of the phosphorus metabolic process, response to abiotic stimulus, regulation of cell population proliferation, regulation of programmed cell death and response to oxygen-containing compounds. The top 10 enriched pathways were selected for future study from 284, including AD, cancer pathways, MAPK signaling, Diabetic cardiomyopathy and proteoglycans in cancer. Our results proved that arbutin can reduce the possibility of developing AD by modulating the activity of primary pathways groups, including its pharmacological mechanism of action in AD, revealing its ten therapeutic targets.
Multimodal Feature Fusion Machine Learning for Predicting Chronic Injury Induced by Engineered Nanomaterials
Authors: Li Xuehua
Published: November 2023

Concerns regarding chronic injuries (e.g., fibrosis and carcinogenesis) induced by nanoparticles raised public health concerns and needs to be rapidly assessed in hazard identification. Although in silico analysis is commonly used for risk assessment of chemicals, predicting chronic in vivo nanotoxicity remains challenging due to the complex interactions at multiple nano-bio interfaces. Herein, we developed a multimodal feature fusion analysis framework to predict the fibrogenic potential of metal oxide nanoparticles (MeONPs). Eighty-seven features derived from multiple MeONP-lung interfaces were used to develop a machine learning-based predictive framework. We identified viability damage and cytokine (IL-1β and TGF-β1) production in macrophages and epithelial cells as key events that are closely associated with particle size, surface charge, and interactions with lysosomes. Experimental validations showed that the developed in silico model had 85% accuracy in predicting MeONP-induced lung fibrosis. The heterogeneity distribution of data points indicated good applicability of the predictive model. Our findings demonstrate the potential usefulness of this predictive model for risk assessment of nanomaterials and in assisting regulatory decision making.
Optimizing the wells location using the Machine learning algorithms, as well as optimizing the drilling time of production and injection wells in one of the reservoirs in south west of Iran
Authors: Nikravesh Hamed , Ranjbar Ali , Azin Reza
Published: November 2023

In this study, the optimization of the location of oil production and injection wells, the number of production and injection wells, and the economic evaluation in the water injection process has been carried out using three algorithms: PSO, GA, and HGAPSO. Optimizing the oil extraction process by optimizing well locations, the optimal number of production and injection wells, and economic evaluation can improve the performance and efficiency of the process. In this study, the optimization of the water injection process into oil reservoirs using the PSO, GA, and HGAPSO algorithms has been addressed. Additionally, economic evaluation, considering costs and profits from oil production using the best-optimized parameters, has been conducted, and the best Net Present Value (NPV) has been calculated. Initially, the optimal well location problem is modeled, taking into account reservoir characteristics and geological conditions. Using the PSO and GA algorithms, the best well location and number of water injection wells have been obtained, leading to improved efficiency and cost reduction. Then, the GA algorithm is used to combine and modify viewpoints and optimize the number and location of wells. This algorithm explores optimal solutions in the well location space. Economic evaluation is performed using the best-optimized parameters by the algorithms. Costs of water injection, oil production costs, and profits from increased oil production are considered. By calculating the best Net Present Value (NPV), optimal decisions regarding the water injection process and enhancing the performance of oil reservoirs are made. Simulation results indicate that the GA algorithm outperforms other algorithms and can be used as a robust and effective method for optimizing well locations and the number of production and injection wells in the oil injection process. Ultimately, this study assists the oil industry in making better decisions about optimizing water injection and improving the efficiency and profitability of the process using the introduced optimization algorithms.
Performance Analysis of SVD and LSB Steganography Data Hiding Techniques: 6G Network Security Survey
Authors: Sr Tarek , Eltokhy Mostafa , Abouelazm Atef E. , El-Bendary Mohsen A. M.
Published: November 2023

The proposed visions for the sixth generation wireless communications network indicate that it will have the ability to transmit massive amounts of data in a very short time. These visions require the sixth-generation network to have a high level of security. This paper focuses on the confidentiality and privacy of data on the sixth-generation wireless communications network. The paper provides a comparison between two techniques of data hiding and showing that may be used with modern security technologies in sixth-generation networks, namely LSBsteganography and SVD watermarking.This comparison between the two technologies is to determine the strength and reliability of each technology in hiding and showing data without affecting it during transmission over the network. This paper provides the comparison by implementing some simulation experiments using these technologies on different types of data such as images, numerical data, and text messages. The simulation results showed the strength and reliability of each technology in hiding and showing data, as well as the impact of each technology on the transmitted data and whether it caused any loss or not.
Shared and different immune molecular signatures of lung transcriptome between connective tissue disease associated and idiopathic pulmonary arterial hypertension
Authors: Huang Kangping , Qian Junyan , Yang Xinzhuang , Ding Yufang , Liu Wenhao , Zhao Jiuliang , Wang Qian , Tian Zhuang , Li Mengtao , Zeng Xiaofeng
Published: November 2023

Background
Pulmonary arterial hypertension (PAH) is one of severe pulmonary circulatory complications and could be idiopathic or associated with connective tissue diseases (CTD). Immune mechanism has been discovered as an important mechanism in both idiopathic PAH (IPAH) and CTD-associated PAH (CTD-PAH). However, differences in immune response between IPAH and CTD-PAH need further exploration. This study compared the immune features of IPAH and CTD-PAH with integrated transcriptomics data from lung tissue.
Methods
Microarray data (GSE48149, GSE113439, and GSE117261) were downloaded from NCBI GEO. Differentially expressed genes (DEGs) were screened by limma package. Functional enrichment analysis and Gene set enrichment analysis (GSEA) were performed. Weighted gene co-expression network analysis (WGCNA) was conducted to screen immune-related module correlated with the two diseases. A specific Protein-Protein Interaction (PPI) network based on screened modules and the most representative pathway with the disease were visualized using Pathview. Potential targeted drug were selected based on selected DEGs and Drugbank database.
Results
Transcriptome data from 19 CTD-PAH patients, 46 IPAH patients and 45 healthy controls (HCs) were collected and integrated. 394 and 207 DEGs were identified in CTD-PAH and IPAH respectively and 111 shared DEGs were found. Inflammatory response were found enriched in shared DEGs, while CTD-PAH-specific pathways were more relevant to innate immune response. WGCNA analysis and following enrichment identified TNF signaling pathway correlated with CTD-PAH and Th1/Th2 differentiation pathway correlated with IPAH. Hub genes found in CTD-PAH included IL6 and CCL2, and in IPAH, CCL5 and IFNG were found to potentially play important roles. Possible drugs targeting discovered genes included adalimumab in CTD-PAH and emapalumab in IPAH.
Conclusions
This study revealed the shared and different characteristics of transcriptome between CTD-PAH and IPAH, particularly in immune response. Our results provide more basis for further research design in the pathophysiologic processes in lung and potential drug discovery.
On the Nonlinearity of the Foreperiod Effect
Authors: Chatroudi Amirmahmoud Houshmand , Mioni Giovanna , Yotsumoto Yuko
Published: November 2023

One of the frequently employed tasks within the implicit timing paradigm is the foreperiod task. The foreperiod is the time interval spanning from the presentation of a warning signal to the appearance of a target stimulus, during which reaction time trajectory follows time uncertainty. While the typical approach in analyzing foreperiod effects is based on linear approximations, the uncertainty in the estimation of time, expressed by the Weber fraction, implies a nonlinear trend. In this study, we analyzed the variable foreperiod reaction times from a relatively large sample (n = 109). We found that the linear regression on reaction times and log-transformed reaction times poorly fitted the foreperiod data. However, a nonlinear regression based on an exponential decay function with three distinctive parameters provided the best fit. We discussed the inferential hazards of a simplistic linear approach and demonstrated how a nonlinear formulation can create new opportunities for studies in implicit timing research, which were previously impossible.
On Categorical Approach to Reaction Systems
Authors: Kaniecki Mariusz , Mikulski Łukasz
Published: November 2023

In every matured theory, there is a need to investigate possible relationships between considered objects. To address this issue, it is natural to relate a category with given model of computing. Thanks to such approach, many properties are unified and simplified. In this paper, we investigate how category theory can be used to give a faithful semantics for reaction systems. In particular, we propose and discuss possible approaches to the problem of defining morphisms between reaction systems. We provide the definition of morphism that keep the behaviour of the original reaction system. Especially, some equivalences of reaction systems are reflected in terms of morphisms. For this purpose we expressed isomorphisms and sections in term of transition systems. Moreover, accelerating morphism defined in the last section give a new approach for including time in reaction system.
Numerical study of the performance of compaction grouting in structured clay using a hypoplastic model
Authors: Diao Yu , Jia Zhenyang , Zhu Pengyu , Zheng Gang , Peng Jun
Published: November 2023

Previous studies on compaction grouting mainly focused on reconstituted clay but did not consider the widespread structure of natural clay. Unlike reconstituted clay, the stress state and void ratio are independent in structured clay due to weathering. Thus S, the state parameter of structured clay, was proposed in this paper to more accurately describe the state of structured clay. Rs, the relative state parameter of structured clay was also proposed to normalize S. Then the numerical hypoplastic constitutive model of structured clay was implemented to evaluate the performance of compaction grouting in structured clay. It shows that the grout efficiency increases with sensitivity when Rs=0 but decreases when Rs=1. Besides, the grout efficiency and grout pressure decrease with increasing Rs. For structured clay with different values of S, there exists a certain value of Rs where the grout efficiency and grout pressure are equivalent to those of the corresponding reconstituted clay. Furthermore, the results were compared with those of heavily overconsolidated clay. It is determined that although negative pore pressure appears in both the horizontal direction and vertical direction in the structured clay when Rs=0, it only appears in the horizontal direction in heavily overconsolidated clay during grouting.
Pharmacological HIF-1 activation upregulates exosome production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin
Authors: Fujii Kohei , Fujishima Yuya , Kita Shunbun , Kawada Keitaro , Fukuoka Keita , Sakaue Taka-aki , Okita Tomonori , Kawada-Horitani Emi , Nagao Hirofumi , Fukuda Shiro , Maeda Norikazu , Nishizawa Hitoshi , Shimomura Iichiro
Published: November 2023

Pharmacological activation of hypoxia-inducible factor 1alpha (HIF-1α), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demonstrated that a HIF-1 activator enhanced exosome production from cultured endothelial cells synergistically with adiponectin, an adipocyte-derived factor, through both transcriptional induction and posttranscriptional stabilization of an adiponectin binding partner, T-cadherin. Increased exosome levels were observed in wild-type mice but not in T-cadherin null mice after consecutive administration of roxadustat. Adiponectin- and T-cadherin-dependent increased exosome production may be involved in the pleiotropic effects of HIF-1 activators.
Anomalously acting agents: the deployment problem
Authors: Wenger Ingeborg , Ebel Henrik , Eberhard Peter
Published: November 2023

The detection of intentionally antagonistic behavior in robot swarms brings about challenges that exceed identifying merely erroneous behavior. We investigate a data-based approach to recognize antagonistic behavior in robots executing a deployment task. The task requires a robot swarm of variable size and start positions to optimally distribute within an arbitrary convex surveillance area. Combining a long short-term memory neural network and a normalizing flow, our approach learns to approximate the probability of a robot action. Thus, actions with low probability density values can be categorized as anomalous. The applicability of the proposed approach is validated on simulated runs containing benevolent, antagonistic, and erroneous robots. Both antagonistic and erroneous robots are detected with an accuracy of more than 90 percent.
Identification and functional analysis of proteins in Pomacea canaliculate gut contents: a proteomics analysis
Authors: Li Dan , Liu Jing , Hu Wei , Li Jiang , Liu Lei , Yang Hua
Published: November 2023

Pomacea canaliculate is an invasive pest originating from South America. It has strong adaptability to the environment and can endanger local biodiversity, agricultural production, and human health. P. canaliculate can ingest a wide variety of food by a well-developed digestive and diverse feeding mechanisms. Aiming to target the digestive system as the way to control the spread of P. canaliculate, we conducted quantitative proteomics to comprehensively elucidate the protein composition in the gut contents of P. canaliculate. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) assay suggested that 845 proteins and 5861 unique peptides were identified in the gut contents of P. canaliculate. Among of the proteins, the EF-hand domain-containing proteins are the most abundance proteins. It has been suggested that EF-hand domain-containing proteins may participate in the formation of calcareous eggshell. Additionally, we discussed the structure and function of 11 cellulases detected from the gut contents of P. canaliculate. These cellulases were divided into three groups belonging to the Glycoside hydrolase family 9, Glycoside hydrolase family 10 and Glycoside hydrolase family 45, respectively. Notably, these cellulases play an important role in the digestion of cellulose. These findings put forth novel possibilities for exploring new safe, easy and efficient control measures of P. canaliculate.
EfficientPose: A Lightweight And Efficient Model with Transformer For Human Pose Estimation
Authors: Liang Wei , Cheng Zhang , Wang Yanxia , Han Junjia
Published: November 2023

The current methods for human pose estimation focus on improving the accuracy of prediction results, but they overlook the significant issues of computational cost and large number of parameters in practical deployment.Although some lightweight pose estimation models have successfully in reducing the number of parameters, lightweight models typically employ smaller convolutional kernel to reduce the model size, leading to insufficient capture of contextual information.To address this issue, this paper constructs a lightweight network model EfficientPose.Specifically, to expand the receptive field and acquire richer feature information without increasing computational costs, this paper proposes the Efficient Bottleneck Block (EBB) module.Additionally, to capture global spatial dependencies and enhance the representation capability of low-resolution features, a Transformer encoder is introduced into the model.Meanwhile, to overcome the issue of excessively long training time for lightweight models, a novel iterative training strategy is proposed to fully unleash the potential of EfficientPose.To validate the effectiveness of EfficientPose model, extensive comparative experiments and ablation studies are conducted in this paper.Compared with HRNet-W48, which has the same backbone network, EfficientPose not only reduces the number of parameters by 72\% when the input image size is the same but also improves the accuracy by 0.8 and 0.9 percentage points in the validation and test sets of COCO, respectively.Experiments show that the EfficientPose model can maintain high accuracy even with a significant reduction in the number of parameters.This provides the potential for further application in real-world scenarios with limited resources.
Acceptance and feasibility of a low-threshold and substitution services-based periodical monitoring system for blood-borne and sexually transmitted infections among people who inject drugs in Germany: a mixed-methods analysis
Authors: Krings Amrei , Steffen Gyde , Zimmermann Ruth
Published: November 2023

Background
To reach the global elimination goals of viral hepatitis B and C (HBC, HCV), human immunodeficiency virus (HIV) and other sexually transmitted infections as a public health threat by 2030, monitoring is needed. Staff members of drug services and opioid substitution treatment (OST) practices in Berlin and Bavaria recruited clients for a pilot study addressing the respective infections among people who injected drugs (PWID) in Germany, 2021/2022. Participants filled a questionnaire and were tested for HBV, HCV, HIV and syphilis using dried blood spots (DBS). We evaluated the study design to implement a feasible and accepted nationwide periodical monitoring among PWID and serve as an example for the implementation of similar monitoring systems in other countries.
Methods
A mixed-methods design was used, including focus group discussions with study participants and staff members and a semi-quantitative questionnaire filled by the latter. Aspects covered were the setting for recruitment, study preparation for staff members, willingness of clients to participate, the study questionnaire, blood collection and return of results.
Results
The majority (96%) of 668 study participants were recruited in low-threshold services, drug consumption rooms and OST-practices. Flexibility of recruiting study participants during routine work or testing weeks/days was important to the facilities. Collaborations with local AIDS services helped cope with the work load of data collection. The need to train staff for DBS collection was highlighted. Study participants welcomed the testing opportunity in familiar places. Study participants frequently needed assistance to complete the study questionnaire. Return of results was considered as ethically mandatory by staff members but referral to treatment remained challenging.
Conclusions
For a successful monitoring time flexibility and adequate training are essential. Individual benefits for study participants by receiving their test results should be ensured and referral networks with infectiology practices may increase number of infected PWID receiving treatment. Overall, the evaluation confirmed that a monitoring through drug services and OST-practices is feasible and well accepted in Germany. Beyond that It shows important lessons learned for the implementation in other countries.