bluuebunny/crossref_metadata_2025 huggingface dataset:
Microstructure and Morphology Control of Potassium Magnesium Titanates and Sodium Iron Titanates by Molten Salt Synthesis
Authors: Zhang Haoran , Li Mengshuo , Zhou Ze , Shen Liming , Bao Ningzhong
Published: May 2019

Titanates materials have attracted considerable interest due to their unusual functional and structural properties for many applications such as high-performance composites, devices, etc. Thus, the development of a large-scale synthesis method for preparing high-quality titanates at a low cost is desired. In this study, a series of quaternary titanates including K0.8Mg0.4Ti1.6O4, Na0.9Mg0.45Ti1.55O4, Na0.75Fe0.75Ti0.25O2, NaFeTiO4, and K2.3Fe2.3Ti5.7O16 are synthesized by a simple molten salt method using inexpensive salts of KCl and NaCl. The starting materials, intermediate products, final products, and their transformations were studied by using TG-DSC, XRD, SEM, and EDS. The results show that the grain size, morphology, and chemical composition of the synthesized quaternary titanates can be controlled simply by varying the experimental conditions. The molar ratio of mixed molten salts is critical to the morphology of products. When KCl:NaCl = 3:1, the morphology of K0.8Mg0.4Ti1.6O4 changes from platelet to board and then bar-like by increasing the molar ratio of molten salt (KCl–NaCl) to raw materials from 0.7 to 2.5. NaFeTiO4 needles and Na0.75Fe0.75Ti0.25O2 platelets are obtained when the molar ratio of molten salt (NaCl) to raw materials is 4. Pure phase of Na0.9Mg0.45Ti1.55O4 and K2.3Fe2.3Ti5.7O16 are also observed. The formation and growth mechanisms of both potassium magnesium titanates and sodium iron titanates are discussed based on the characterization results.
Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049
Authors: Xu Xiuli , Han Jiahui , Wang Yanan , Lin Rui , Yang Haijin , Li Jiangpeng , Wei Shangzhu , Polyak Steven W. , Song Fuhang
Published: May 2019

Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds.
Zeaxanthin Isolated from Dunaliella salina Microalgae Ameliorates Age Associated Cardiac Dysfunction in Rats through Stimulation of Retinoid Receptors
Authors: El-Baz Farouk Kamel , Hussein Rehab Ali , Saleh Dalia Osama , Abdel Jaleel Gehad Abdel Raheem
Published: May 2019

Retinoids are essential during early cardiovascular morphogenesis. However, recent studies showed their important role in cardiac remodeling in rats with hypertension and following myocardial infarction. The present study aimed to investigate the effect of zeaxanthin heneicosylate (ZH); a carotenoid ester isolated from Dunaliella salina microalgae, on cardiac dysfunction ensuing d-galactose injection in rats. Rats injected with d-GAL (200 mg/kg; I.P) for 8 weeks were orally treated with ZH (250 μg/kg) for 28 consecutive days. Results showed that d-GAL injection caused dramatic electrocardiographic changes as well as marked elevation in serum levels of homocysteine, creatinine kinase isoenzyme and lactate dehydrogenase. A reduction in the cardiac contents of glucose transporter-4 and superoxide dismutase along with the elevation of inducible nitric oxide synthetase and interleukin-6 was also noticed. Oral administration of ZH significantly improved the above mentioned cardiac aging manifestations; this was further emphasized through histopathological examinations. The effect of ZH is mediated through the interaction with retinoid receptor alpha (RAR-α) as evidenced through a significant elevation of RAR-α expression in cardiac tissue following the lead of an in silico molecular docking study. In conclusion, zeaxanthin heneicosylate isolated from D. salina ameliorated age-associated cardiac dysfunction in rats through the activation of retinoid receptors.
Specific Urinary Metabolites in Malignant Melanoma
Authors: Valko-Rokytovská Marcela , Hubková Beáta , Birková Anna , Mašlanková Jana , Stupák Marek , Zábavníková Marianna , Čižmárová Beáta , Mareková Mária
Published: May 2019

Background and objectives: Melanin, which has a confirmed role in melanoma cell behaviour, is formed in the process of melanogenesis and is synthesized from tryptophan, L-tyrosine and their metabolites. All these metabolites are easily detectable by chromatography in urine. Materials and Methods: Urine samples of 133 individuals (82 malignant melanoma patients and 51 healthy controls) were analysed by reversed-phase high-performance liquid chromatography (RP-HPLC). The diagnosis of malignant melanoma was confirmed histologically. Results: Chromatograms of melanoma patients showed increased levels of 5,6-dihydroxyindole-2-carboxylic acid, vanilmandelic acid, homovanilic acid, tryptophan, 5-hydroxyindole-3-acetic acid, and indoxyl sulphate compared to healthy controls. Concentration of indoxyl sulphate, homovanilic acid and tryptophan were significantly increased even in the low clinical stage 0 of the disease (indoxyl sulphate, homovanilic acid and tryptophan in patients with clinical stage 0 vs. controls expressed as medium/ interquartile range in µmol/mmol creatinine: 28.37/15.30 vs. 5.00/6.91; 47.97/33.08 vs. 7.33/21.25; and 16.38/15.98 vs. 3.46/6.22, respectively). Conclusions: HPLC detection of metabolites of L-tyrosine and tryptophan in the urine of melanoma patients may play a significant role in diagnostics as well as a therapeutic strategy of melanoma cancer.
Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary Study
Authors: Panella Lorenzo , Volontè Laura , Poloni Nicola , Caserta Antonello , Ielmini Marta , Caselli Ivano , Lucca Giulia , Callegari Camilla
Published: May 2019

Background and Objectives: Pain is one of the most common symptoms that weighs on life’s quality and health expenditure. In a reality where increasingly personalized therapies are needed, the early use of genetic tests that highlights the individual response to analgesic drugs could be a valuable help in clinical practice. The aim of this preliminary study is to observe if the therapy set to 5 patients suffering of chronic or acute pain is concordant to the Pharmacogenetic test (PGT) results. Materials and Methods: This preliminary study compares the genetic results of pharmacological effectiveness and tolerability analyzed by the genetic test Neurofarmagen Analgesia®, with the results obtained in clinical practice of 5 patients suffering from acute and chronic pain. Results: Regarding the genetic results of the 5 samples analyzed, 2 reports were found to be completely comparable with the evidences of the clinical practice, while in 3 reports the profile of tolerability and effectiveness were partially discordant. Conclusion: In light of the data not completely overlapping with results observed in clinical practice, further studies would be appropriate in order to acquire more information on the use of Neurofarmagen in routine clinical settings.
Retrospective Toxicological Profiling of Radium-223 Dichloride for the Treatment of Bone Metastases in Prostate Cancer Using Adverse Event Data
Authors: Soldatos Theodoros G. , Iakovou Ioannis , Sachpekidis Christos
Published: May 2019

Background and Objective: Radium-223 dichloride (Xofigo®) is a calcium mimetic agent approved for the treatment of castration-resistant prostate cancer patients with symptomatic bone metastases and no known visceral metastatic disease. This targeted, α-particle-emitting therapy has demonstrated significant survival benefit accompanied by a favorable safety profile. Nevertheless, recent evidence suggests that its combined use with abiraterone and prednisone/prednisolone may be associated with increased risk of death and fractures. While the precise pathophysiologic mechanisms of these events are not yet clear, collecting evidence from more clinical trials and translational studies is necessary. The aim of our present study is to assess whether accessible sources of patient outcome data can help gain additional clinical insights to radium-223 dichloride’s safety profile. Materials and Methods: We performed a retrospective analysis of cases extracted from the FDA Adverse Event Reporting System and characterized side effect occurrence by using reporting ratios. Results: A total of ~1500 prostate cancer patients treated with radium-223 dichloride was identified, and side effects reported with the use of radium-223 dichloride alone or in combination with other therapeutic agents were extracted. Our analysis demonstrates that radium-223 dichloride may often come with hematological-related reactions, and that, when administered together with other drugs, its safety profile may differ. Conclusions: While more prospective studies are needed to fully characterize the toxicological profile of radium-223 dichloride, the present work constitutes perhaps the first effort to examine its safety when administered alone and in combination with other agents based on computational evidence from public real-world post marketing data.
The Oxidative Stress in Knee Osteoarthritis Patients. An Attempt of Evaluation of Possible Compensatory Effects Occurring in the Disease Development
Authors: Paździor Marek , Kiełczykowska Małgorzata , Kurzepa Jacek , Luchowska-Kocot Dorota , Kocot Joanna , Musik Irena
Published: May 2019

Background and Objective: Osteoarthritis (OA) is a disorder of the musculoskeletal system resulting in worsening of life condition. The research revealed the involvement of oxidative stress into both OA pathogenesis and the effects of therapeutic agents applied in OA cases. The activities of the most important antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and total antioxidant status (TAS), in blood of the knee OA patients were studied, with the aim of clarifying which enzymatic antioxidants are involved into osteoarthritis (OA)-related oxidative stress and whether any compensatory effects occur. The results were additionally analyzed with regard to gender. Methods: Whole blood SOD (U/mL), plasma GPx (U/L) and CAT (U/mL) activities as well as plasma TAS (mmol/L)) in knee OA patients were investigated. Sixty-seven patients (49 females and 18 males) with primary knee OA were enrolled. The control comprised 21 subjects (10 females and 11 males) free of osteoarthritis or inflammation. Results: TAS was decreased in OA subjects (4.39 ± 0.53 vs. 4.70 ± 0.60), with this effect being more significant in OA females (4.31 ± 0.51 vs. 5.02 ± 0.54). GPx was depressed in all OA patients (518 ± 176 vs. 675 ± 149). In both genders, GPx was decreased, significantly in males (482 ± 185 vs. 715 ± 105). SOD was decreased in all OA patients (109 ± 32 vs. 127 ± 42). CAT showed no difference in all OA subjects vs. control, while in OA females it was depleted (20.2 (11.6–31.6) vs. 38.5 (27.9–46.6)) and in OA men it increased (26.9 (23.3–46.5) vs. 14.0 (7.0–18.6)). Conclusions: The obtained results suggest that in men some compensatory mechanisms towards OA-related oxidative stress occurred. Based on the obtained data, the introduction of antioxidant supplements into OA therapy could be suggested with further research concerning the choice of agents.
The Influence of Talc Addition on the Performance of Polypropylene Membranes Formed by TIPS Method
Authors: Gryta Marek
Published: May 2019

The effect of talc addition on the morphology of capillary membranes formed by a thermally induced phase separation (TIPS) method was investigated in the presented work. The usability of such formed membranes for membrane distillation was evaluated. Two types of commercial capillary polypropylene membranes, fabricated for microfiltration process, were applied in the studies. A linear arrangement of polymer chains was obtained in the walls of membranes formed without a talc addition. In the case of membranes blended with talc, the linear structure was disordered, and a more porous structure was obtained. The changes in morphology enhanced the mechanical properties of blended membranes, and their lower thermal degradation was observed during 350 h of membrane distillation studies. Long-term studies confirmed the stability of talc dispersion in the membrane matrix. A leaching of talc from polypropylene (PP) membranes was not found during the membrane distillation (MD) process.
Environmentally Assisted Cracking Behavior of S420 and X80 Steels Containing U-notches at Two Different Cathodic Polarization Levels: An Approach from the Theory of Critical Distances
Authors: González Pablo , Cicero Sergio , Arroyo Borja , Álvarez José
Published: May 2019

This paper analyzes, using the theory of critical distances, the environmentally assisted cracking behavior of two steels (S420 and API X80) subjected to two different aggressive environments. The propagation threshold for environmentally assisted cracking (i.e., the stress intensity factor above which crack propagation initiates) in cracked and notched specimens (KIEAC and KNIEAC) has been experimentally obtained under different environmental conditions. Cathodic polarization has been employed to generate the aggressive environments, at 1 and 5 mA/cm2, causing hydrogen embrittlement on the steels. The point method and the line method, both belonging to the theory of critical distances, have been applied to verify their capacity to predict the initiation of crack propagation. The results demonstrate the capacity of the theory of critical distances to predict the crack propagation onset under the different combinations of material and aggressive environments.
Community- and Hospital-Acquired Klebsiella pneumoniae Urinary Tract Infections in Portugal: Virulence and Antibiotic Resistance
Authors: Caneiras Cátia , Lito Luis , Melo-Cristino José , Duarte Aida
Published: May 2019

Klebsiella pneumoniae is a clinically relevant pathogen and a frequent cause of hospital-acquired (HA) and community-acquired (CA) urinary tract infections (UTI). The increased resistance of this pathogen is leading to limited therapeutic options. To investigate the epidemiology, virulence, and antibiotic resistance profile of K. pneumoniae in urinary tract infections, we conducted a multicenter retrospective study for a total of 81 isolates (50 CA-UTI and 31 HA-UTI) in Portugal. The detection and characterization of resistance and virulence determinants were performed by molecular methods (PCR, PCR-based replicon typing, and multilocus sequence typing (MLST)). Out of 50 CA-UTI isolates, six (12.0%) carried β-lactamase enzymes, namely blaTEM-156 (n = 2), blaTEM-24 (n = 1), blaSHV-11 (n = 1), blaSHV-33 (n = 1), and blaCTX-M-15 (n = 1). All HA-UTI were extended-spectrum β-lactamase (ESBL) producers and had a multidrug resistant profile as compared to the CA-UTI isolates, which were mainly resistant to ciprofloxacin, levofloxacin, tigecycline, and fosfomycin. In conclusion, in contrast to community-acquired isolates, there is an overlap between virulence and multidrug resistance for hospital-acquired UTI K. pneumoniae pathogens. The study is the first to report different virulence characteristics for hospital and community K. pneumoniae pathogens, despite the production of β-lactamase and even with the presence of CTX-M-15 ESBL, a successful international ST15 clone, which were identified in both settings. This highlights that a focus on genomic surveillance should remain a priority in the hospital environment.
β-Thujone and Its Derivatives Modify the Probing Behavior of the Peach Potato Aphid
Authors: Wróblewska-Kurdyk Anna , Gniłka Radosław , Dancewicz Katarzyna , Grudniewska Aleksandra , Wawrzeńczyk Czesław , Gabryś Beata
Published: May 2019

Thujone is a natural biologically active monoterpene ketone component of essential oils of numerous plants. The aim of the study was to evaluate the effect of β-thujone and β-thujone derivatives bisulfite adduct, lactone, oxime, and lactam application on behavior of Myzus persicae (Sulz.) (Hemiptera: Aphididae) during probing and settling. The choice and no-choice tests (aphid settling and Electrical Penetration Graph (EPG), respectively) revealed that stereochemistry of thujone was important for biological activity (β-thujone caused changes in aphid behavior while α-thujone did not) and that cyclopentane ring modifications and functional groups addition gave derivatives that possessed stronger and more durable deterrent effects. The most effective modification was the incorporation of a lactam moiety into the β-thujone molecule. Application of β-thujone lactam limited aphid settling for at least 24 h, caused restlessness in aphids and a delay or failure in reaching phloem phase by M. persicae. β-Thujone lactam can be considered a deterrent of medium potency with activity expressed at preingestive phase of aphid probing. Other compounds did not restrain aphid stylet penetration in non-phloem tissues but slightly limited sap ingestion (lactone, oxime), and restrained aphid settling for a period of less than 24 h (β-Thujone, bisulphite adduct, lactone).
Structural Characterization and Anti-Proliferation Activities Against Tumor Cells of an Arabinogalactan from Juniperus convallium
Authors: Li Beibei , Dong Mengxue , De Ji , Ye Li , Chen Daofeng , Lu Yan
Published: May 2019

As a hyperproliferative disorder, cancer has continued to be a major public health challenge. In the present study, a polysaccharide JC-PS1 was isolated and purified from Juniperus convallium. JC-PS1 is a heteropolysaccharide composed of Ara, Gal, GalA and Rha with the average molecular weight of 280 kDa. Based on the methylation and 2D NMR analysis, JC-PS1 was elucidated as a backbone of →5)-α-Araf-(1→ and →3,5)-α-Araf-(1→, and three kinds of branches attached to the O-3 position of →3,5)-α-Araf-(1→, including β-GalpA-(1→3)-β-Galp-(1→, α-Araf-(1→3)-α-Rhap-(1→ and α-Araf-(1→3)-β-Galp-(1→. Accordingly, the atomic force microscopy of JC-PS1 showed a linear filamentous structure with small proportion of branches. Furthermore, JC-PS1 exhibited significant anti-proliferation activities against PANC-1, A431, MDA-MB-231, U118MG and H1975 cells with the IC50 values of 296.8, 477.9, 657.4, 686.7 and 862.1 μg/mL, respectively. This indicated that JC-PS1 could be a potential therapeutic agent for the treatment of cancer.
Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry
Authors: Zeng Wenjuan , Zhang Yanyan , Zheng Wei , Luo Qun , Han Juanjuan , Liu Jian’an , Zhao Yao , Jia Feifei , Wu Kui , Wang Fuyi
Published: May 2019

The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT4CTT7G8C9T10TCTCC-3′ (ODN15), using ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) in conjunction with tandem mass spectrometry (top-down MS). Top-down MS analysis with collision-induced dissociation (CID) fragmentation of the mono-platinated and di-platinated ODN15 provided abundant and informative Pt-containing or Pt-free a/[a − B], w and internal fragments, allowing the unambiguous identification of T4, T7, C9, and T10 as the platination sites on the cisplatin-ODN15 adducts. These results revealed that, in addition to the well-established guanine site, the unexpected thermodynamic binding of cisplatin to cytosine and thymine bases was also evident at the oligonucleotide level. Furthermore, the binding models of cisplatin with cytosine and thymine bases were built as the Pt coordinated to cytosine-N(3) and thymine-N(3) with displacement of the proton or tautomerization of thymine. These findings contribute to a better understanding of the mechanism of action of cisplatin and its preference for gene loci when the drug binds to cellular DNA, and also demonstrate the great potential and superiority of FT-ICR MS in studying the interactions of metallodrugs with large biomolecules.
Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential
Authors: Salehi Bahare , Capanoglu Esra , Adrar Nabil , Catalkaya Gizem , Shaheen Shabnum , Jaffer Mehwish , Giri Lalit , Suyal Renu , Jugran Arun K , Calina Daniela , Docea Anca Oana , Kamiloglu Senem , Kregiel Dorota , Antolak Hubert , Pawlikowska Ewelina , Sen Surjit , Acharya Krishnendu , Selamoglu Zeliha , Sharifi-Rad Javad , Martorell Miquel , Rodrigues Célia F. , Sharopov Farukh , Martins Natália , Capasso Raffaele
Published: May 2019

Cucurbita genus has received a renowned interest in the last years. This plant species, native to the Americas, has served worldwide folk medicine for treating gastrointestinal diseases and intestinal parasites, among other clinical conditions. These pharmacological effects have been increasingly correlated with their nutritional and phytochemical composition. Among those chemical constituents, carotenoids, tocopherols, phenols, terpenoids, saponins, sterols, fatty acids, and functional carbohydrates and polysaccharides are those occurring in higher abundance. However, more recently, a huge interest in a class of triterpenoids, cucurbitacins, has been stated, given its renowned biological attributes. In this sense, the present review aims to provide a detailed overview to the folk medicinal uses of Cucurbita plants, and even an in-depth insight on the latest advances with regards to its antimicrobial, antioxidant and anticancer effects. A special emphasis was also given to its clinical effectiveness in humans, specifically in blood glucose levels control in diabetic patients and pharmacotherapeutic effects in low urinary tract diseases.
Conversion of Furfuryl Alcohol into Ethyl Levulinate over Glucose-Derived Carbon-Based Solid Acid in Ethanol
Authors: Zhao Geng , Liu Ming , Xia Xinkui , Li Li , Xu Bayin
Published: May 2019

In this study, a carbon-based solid acid was created through the sulfonation of carbon obtained from the hydrothermal pretreatment of glucose. Additionally, ethyl levulinate, a viable liquid biofuel, was produced from furfuryl alcohol using the environmentally benign and low-cost catalyst in ethanol. Studies for optimizing the reaction conditions, such as reaction time, temperature, and catalyst loading, were performed. Under the optimal conditions, a maximum ethyl levulinate yield of 67.1% was obtained. The recovered catalyst activity (Ethyl levulinate yield 57.3%) remained high after being used four times, and it was easily regenerated with a simple sulfonation process. Moreover, the catalyst was characterized using FT-IR, XRD, SEM, elemental analysis, and acid-base titration techniques.
Antihypertensive Effects of Corn Silk Extract and Its Novel Bioactive Constituent in Spontaneously Hypertensive Rats: The Involvement of Angiotensin-Converting Enzyme Inhibition
Authors: Li Chia-Cheng , Lee Yu-Chen , Lo Hsin-Yi , Huang Yu-Wen , Hsiang Chien-Yun , Ho Tin-Yun
Published: May 2019

Corn silk tea has been used in folk medicine for anti-hypertensive healthcare. Angiotensin-converting enzyme (ACE) plays a crucial role on the homeostasis of blood pressure. However, effects of corn silk tea on ACE activity and the presence of ACE inhibitory constituents in corn silk are still unknown. Here we applied proteomics and bioinformatics approaches to identify corn silk bioactive peptides (CSBps) that target ACE from the boiling water extract of corn silk (CSE). CSE significantly reduced systolic blood pressure (SBP) levels in spontaneously hypertensive rats and inhibited the ACE activity. By proteomics coupled with bioinformatics analyses, we identified a novel ACE inhibitory peptide CSBp5 in CSE. CSBp5 significantly inhibited the ACE activity and decreased SBP levels in a dose-dependent manner. Docking analysis showed that CSBp5 occupied the substrate-binding channel of ACE and interacted with ACE via hydrogen bonds. In conclusion, we identified that CSE exhibited anti-hypertensive effects in SHRs via the inhibition of ACE, the target of most anti-hypertensive drugs. In addition, an ACE inhibitory phytopeptide CSBp5 that decreased SBP levels in rats was newly identified. Our findings supported the ethnomedical use of corn silk tea on hypertension. Moreover, the identification of ACE inhibitory phytopeptide in corn silk further strengthened our findings.
Probing the Optical Properties of MoS2 on SiO2/Si and Sapphire Substrates
Authors: Han Tao , Liu Hongxia , Wang Shulong , Chen Shupeng , Li Wei , Yang Xiaoli , Cai Ming , Yang Kun
Published: May 2019

As an important supplementary material to graphene in the optoelectronics field, molybdenum disulfide (MoS2) has attracted attention from researchers due to its good light absorption capacity and adjustable bandgap. In this paper, MoS2 layers are respectively grown on SiO2/Si and sapphire substrates by atmospheric pressure chemical vapor deposition (APCVD). Atomic force microscopy, optical microscopy, and Raman and photoluminescence spectroscopy are used to probe the optical properties of MoS2 on SiO2/Si and sapphire substrates systematically. The peak shift between the characteristic A1g and E12g peaks increases, and the I peak of the PL spectrum on the SiO2/Si substrate redshifts slightly when the layer numbers were increased, which can help in obtaining the layer number and peak position of MoS2. Moreover, the difference from monolayer MoS2 on the SiO2/Si substrate is that the B peak of the PL spectrum has a blueshift of 56 meV and the characteristic E12g peak of the Raman spectrum has no blueshift. The 1- and 2-layer MoS2 on a sapphire substrate had a higher PL peak intensity than that of the SiO2/Si substrate. When the laser wavelength is transformed from 532 to 633 nm, the position of I exciton peak has a blueshift of 16 meV, and the PL intensity of monolayer MoS2 on the SiO2/Si substrate increases. The optical properties of MoS2 can be obtained, which is helpful for the fabrication of optoelectronic devices.
Thermoelectric Inversion in a Resonant Quantum Dot-Cavity System in the Steady-State Regime
Authors: Abdullah Nzar Rauf , Tang Chi-Shung , Manolescu Andrei , Gudmundsson Vidar
Published: May 2019

We theoretically investigate thermoelectric effects in a quantum dot system under the influence of a linearly polarized photon field confined to a 3D cavity. A temperature gradient is applied to the system via two electron reservoirs that are connected to each end of the quantum dot system. The thermoelectric current in the steady state is explored using a quantum master equation. In the presence of the quantized photons, extra channels, the photon replica states, are formed generating a photon-induced thermoelectric current. We observe that the photon replica states contribute to the transport irrespective of the direction of the thermal gradient. In the off-resonance regime, when the energy difference between the lowest states of the quantum dot system is smaller than the photon energy, the thermoelectric current is almost blocked and a plateau is seen in the thermoelectric current for strong electron–photon coupling strength. In the resonant regime, an inversion of thermoelectric current emerges due to the Rabi-splitting. Therefore, the photon field can change both the magnitude and the sign of the thermoelectric current induced by the temperature gradient in the absence of a voltage bias between the leads.
Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization Study
Authors: Libuda Lars , Laabs Björn-Hergen , Ludwig Christine , Bühlmeier Judith , Antel Jochen , Hinney Anke , Naaresh Roaa , Föcker Manuel , Hebebrand Johannes , König Inke R. , Peters Triinu
Published: May 2019

While observational studies show an association between 25(OH)vitamin D concentrations and depressive symptoms, intervention studies, which examine the preventive effects of vitamin D supplementation on the development of depression, are lacking. To estimate the role of lowered 25(OH)vitamin D concentrations in the etiology of depressive disorders, we conducted a two-sample Mendelian randomization (MR) study on depression, i.e., “depressive symptoms” (DS, n = 161,460) and “broad depression” (BD, n = 113,769 cases and 208,811 controls). Six single nucleotide polymorphisms (SNPs), which were genome-wide significantly associated with 25(OH)vitamin D concentrations in 79,366 subjects from the SUNLIGHT genome-wide association study (GWAS), were used as an instrumental variable. None of the six SNPs was associated with DS or BD (all p > 0.05). MR analysis revealed no causal effects of 25(OH)vitamin D concentration, either on DS (inverse variance weighted (IVW); b = 0.025, SE = 0.038, p = 0.52) or on BD (IVW; b = 0.020, SE = 0.012, p = 0.10). Sensitivity analyses confirmed that 25(OH)vitamin D concentrations were not significantly associated with DS or BD. The findings from this MR study indicate no causal relationship between vitamin D concentrations and depressive symptoms, or broad depression. Conflicting findings from observational studies might have resulted from residual confounding or reverse causation.
Impact of Nutrition on Enhanced Recovery After Surgery (ERAS) in Gynecologic Oncology
Authors: Bisch Steven , Nelson Gregg , Altman Alon
Published: May 2019

Enhanced recovery after surgery (ERAS) pathways aim to improve surgical outcomes by applying evidence-based practices before, during, and after surgery. Patients undergoing surgery for gynecologic malignancies are at high risk of complications due to population, patient, disease, and surgical factors. The nutritional status of the patient provides the foundation for recovery after surgery, and opportunities to optimize outcomes exist from the first patient assessment to the early days after surgery. This review highlights the importance of nutritional assessment and intervention during the pre-operative and post-operative periods in the context of ERAS in gynecologic oncology surgery. The emerging role of immunonutrition, carbohydrate loading, and the importance of individualized care are explored. Evidence from studies in gynecologic oncology is presented, where available, and extrapolated from colorectal and other cancer surgery trials when applicable.
Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene
Authors: Meléndez-Martínez Antonio J. , Stinco Carla M. , Mapelli-Brahm Paula
Published: May 2019

In this work, the importance of dietary carotenoids in skin health and appearance is comprehensively reviewed and discussed. References are made to their applications in health-promoting and nutricosmetic products and the important public health implications that can be derived. Attention is focused on the colourless UV radiation (UVR)-absorbing dietary carotenoids phytoene and phytofluene, which are attracting increased interest in food science and technology, nutrition, health and cosmetics. These compounds are major dietary carotenoids, readily bioavailable, and have been shown to be involved in several health-promoting actions, as pinpointed in recent reviews. The growing evidence that these unique UVR-absorbing carotenoids with distinctive structures, properties (light absorption, susceptibility to oxidation, rigidity, tendency to aggregation, or even fluorescence, in the case of phytofluene) and activities can be beneficial in these contexts is highlighted. Additionally, the recommendation that the levels of these carotenoids are considered in properly assessing skin carotenoid status is made.
Antimicrobial Effect of Thymus capitatus and Citrus limon var. pompia as Raw Extracts and Nanovesicles
Authors: Pinna Roberto , Filigheddu Enrica , Juliano Claudia , Palmieri Alessandra , Manconi Maria , D’hallewin Guy , Petretto Giacomo , Maioli Margherita , Caddeo Carla , Manca Maria Letizia , Solinas Giuliana , Bortone Antonella , Campanella Vincenzo , Milia Egle
Published: May 2019

In view of the increasing interest in natural antimicrobial molecules, this study screened the ability of Thymus capitatus (TC) essential oil and Citrus limon var. pompia (CLP) extract as raw extracts or incorporated in vesicular nanocarriers against Streptococcus mutans and Candida albicans. After fingerprint, TC or CLP were mixed with lecithin and water to produce liposomes, or different ratios of water/glycerol or water/propylene glycol (PG) to produce glycerosomes and penetration enhancer vesicles (PEVs), respectively. Neither the raw extracts nor the nanovesicles showed cytotoxicity against human gingival fibroblasts at all the concentrations tested (1, 10, 100 μg/mL). The disc diffusion method, MIC-MBC/MFC, time-kill assay, and transmission electron microscopy (TEM) demonstrated the highest antimicrobial potential of TC against S. mutans and C. albicans. The very high presence of the phenol, carvacrol, in TC (90.1%) could explain the lethal effect against the yeast, killing up to 70% of Candida and not just arresting its growth. CLP, rich in polyphenols, acted in a similar way to TC in reducing S. mutans, while the data showed a fungistatic rather than a fungicidal activity. The phospholipid vesicles behaved similarly, suggesting that the transported extract was not the only factor to be considered in the outcomes, but also their components had an important role. Even if other investigations are necessary, TC and CLP incorporated in nanocarriers could be a promising and safe antimicrobial in caries prevention.
Interspaced Repeat Sequences Confer the Regulatory Functions of AtXTH10, Important for Root Growth in Arabidopsis
Authors: Cao Jun , Lv Yueqing , Li Xiang
Published: May 2019

An interspaced repeat sequence (IRS) is a unique sequence similar to prokaryotic CRISPR in structure. In this study, 1343 IRSs were identified in the Arabidopsis genome. Functional annotation of the IRS-related genes showed that they were associated with various growth and development processes. More than 30% of the IRSs were located in promoter regions. Deletion of some IRSs affected promoter activity, suggesting their roles in the regulation of gene expression. Next, the function of the AtXTH10 gene was further analyzed, and the expression of this gene was regulated by IRSs in its promoter region. Transgenic and mutant plants analysis indicated that the AtXTH10 gene was associated with root development by affecting cell wall structure. Moreover, the expression profiles of some key genes involved in root development signaling pathways were also affected by AtXTH10. These results suggest that IRSs could be involved in regulating the expression of genes with important roles in plant development.
Agarose/Spherical Activated Carbon Composite Gels for Recyclable and Shape-Configurable Electrodes
Authors: Kim Jong Sik , Kim Ju-Hyung , Cho Younghyun , Shim Tae Soup
Published: May 2019

Soft electrodes have been known as a key component in the engineering of flexible, wearable, and implantable energy-saving or powering devices. As environmental issues are emerging, the increase of electronic wastes due to the short replacement cycle of electronic products has become problematic. To address this issue, development of eco-friendly and recyclable materials is important, but has not yet been fully investigated. In this study, we demonstrated hydrogel-based electrode materials composed of agarose and spherical activated carbon (agar/SAC) that are easy to shape and recycle. Versatile engineering processes were applied thanks to the reversible gelation of the agarose matrix which enables the design of soft electrodes into various shapes such as thin films with structural hierarchy, microfibers, and even three-dimensional structures. The reversible sol–gel transition characteristics of the agar matrix enables the retrieval of materials and subsequent re-configuration into different shapes and structures. The electrical properties of the agar/SAC composite gels were controlled by gel compositions and ionic strength in the gel matrix. Finally, the composite gel was cut and re-contacted, forming conformal contact to show immediate restoration of the conductivity.
A Novel One-Pot Synthesis of Poly(Propylene Carbonate) Containing Cross-Linked Networks by Copolymerization of Carbon Dioxide, Propylene Oxide, Maleic Anhydride, and Furfuryl Glycidyl Ether
Authors: Gao Lijun , Chen Xianggen , Liang Xiangjun , Guo Xiuzhi , Huang Xianling , Chen Caifen , Wan Xiaodan , Deng Ruyu , Wu Qifeng , Wang Lingyun , Feng Jiuying
Published: May 2019

The thermoplastic poly(propylene carbonate) (PPC) containing cross-linked networks was one-pot synthesized by copolymerization of carbon dioxide, propylene oxide (PO), maleic anhydride (MA), and furfuryl glycidyl ether (FGE). The copolymers were characterized by Fourier transform infrared spectroscopy (FT-IR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) measurements. The thermal and dimensional stability of the copolymers were improved. When the MA and FGE load increased from 1 mol% to 4 mol% of PO, the copolymers contained the gel contents of 11.0%–26.1% and their yields were about double that of the PPC. The 5% weight-loss degradation temperatures (Td,-5%) and the maximum weight-loss degradation temperatures (Td,max) increased from 149.7–271.3 °C and from 282.6–288.6 °C, respectively, corresponding to 217.1 °C and 239.0 °C of PPC. Additionally, the hot-set elongation tests showed that the copolymers exhibited elasticity and dimensional stability with the minimum permanent deformation of 6.5% which was far less than that of PPC of 157.2%, while the tensile strengths were a little lower than that of PPC because of the following two conflicting factors, cross-links and flexibility of the units formed by the introduced third monomers, MA and FGE. In brief, we provide a novel method of one-pot synthesis of PPC containing cross-linked networks. According to this idea, the properties would be more extensively regulated by changing the cross-linkable monomers.
Synthesis of Novel pH-Tunable Thermoresponsive Hydroxyl-Terminated Hyperbranched Polyether
Authors: Zhu Xiuzhong , Duan Xiao , Bai Ting , Zhang Xuan , Wang Tong , Cao Tao , Fan Xiaodong
Published: May 2019

In this study, a new pH-tunable thermoresponsive hydroxyl-terminated hyperbranched polyether (HTHP 2) was successfully prepared via a one-pot cationic polymerization technique and postmodification. In the first step, hydroxyl-terminated hyperbranched polyether containing double bonds (HTHP 1) were synthesized. Then, through thiol-ene “click” reaction, pH-responsive carboxyl groups were introduced to the target polymer of HTHP 2. The products were characterized via Fourier-transform infrared spectra (FTIR), nuclear magnetic resonance (NMR), and size-exclusion chromatography-multiangle laser light scattering (SEC-MALLS). Moreover, dynamic light scattering (DLS) and UV–Vis spectroscopy was employed to study the pH- and thermoresponsiveness in detail. Results showed that HTHP 2 possessed typical pH-controllable thermoresponsive behavior. By regulating the solution pH value range 3.0–5.4, LCST of HTHP 2 could be changed from 12.8 to 68.0 °C. Meanwhile, the cell viabilities of A549 cells were more than 80% for in vitro cytotoxicity tests of HTHP 2, suggested that HTHP 2 polymers are of good biocompatibility for up to 24 h.
Polyamine-Based Organo-Clays for Polluted Water Treatment: Effect of Polyamine Structure and Content
Authors: Cristiani Cinzia , Iannicelli-Zubiani Elena Maria , Dotelli Giovanni , Finocchio Elisabetta , Gallo Stampino Paola , Licchelli Maurizio
Published: May 2019

Hybrid materials based on clays and polyamines are supposed to be efficient heavy metals sorbents due to the well-known adsorption behaviour of the clay matrix and to the coordination properties of un-protonated amino groups. For this purpose, a montmorillonite clay was modified with three different aliphatic polyamines: L6 and L10 have a linear structure with six and ten amino groups, respectively, while B14 is a branched polyamine with fourteen amino groups. Initial amine concentration was the main parameter investigated and data were fitted with Langmuir and Freundlich models. Interaction mechanisms between clay and amines were deeply investigated by different experimental techniques such as X-ray powder diffraction (XRD), thermal analysis measurements (DTG), Fourier Transform Infrared Spectroscopy (FT-IR) and diffuse reflectance (NIR) spectroscopy. Experimental results showed that the amount of amines efficiently immobilized in the solid phase can be increased by increasing the initial concentration of polyamines in the clay modification process. These data were best fitted by Freundlich model, indicating a presence of surface sites of different nature. In the resulting hybrid materials, neither the accessibility of the NH/NH2 groups of the amines, nor the accessibility of the structural OH of the clay was hindered. Several preliminary tests in La ions’ uptake and release from aqueous solution were also carried out. In the conditions used for this study, total metal ion removal was achieved at sufficiently low linear amine loadings (i.e., 0.45 mmol/gclay for the small L6 amine), suggesting that these hybrid materials are promising for the proposed application in environmental remediation.
Promoting the Circular Economy via Waste-to-Power (WTP) in Taiwan
Authors: Tsai Wen-Tien
Published: May 2019

The waste management sector significantly contributes to emissions of ambient air pollutants and greenhouse gases, especially in sanitary landfills. In this regard, Taiwan is moving toward a circular economy society via resource recycling and waste-to-power (WTP) in the waste management. In the past decade, the recycling rate of general waste (including recyclable waste, kitchen waste, and bulk waste) increased from 40.97% in 2008 to 60.22% in 2017. On the other hand, 24 large-scale waste incineration plants gained about 2.5 TW-h of net electricity generation, based on 6.25 million metric tons of waste incinerated in 2017. The objectives of this paper are to update the status of waste generation and its WTP in Taiwan. Based on these updated data, the preliminary benefit analysis of WTP showed annual benefits of equivalent electricity charge of around $US 3.3 × 108 (using the feed-in-tariff rate 3.8945 NTD$/kW-h; 1 $US ≈ 30 NTD$) and equivalent CO2 mitigation of about 1.4 million metric tons (using the electricity emissions factor 0.55 kg CO2 equivalent/kW-h). In order to gain environmental, energy, and economic benefits, the regulatory and technological measures for promoting WTP are briefly summarized to create another low-carbon society in Taiwan.
Remote Sensing in Urban Forestry: Recent Applications and Future Directions
Authors: Li Xun , Chen Wendy Y. , Sanesi Giovanni , Lafortezza Raffaele
Published: May 2019

Increasing recognition of the importance of urban forest ecosystem services calls for the sustainable management of urban forests, which requires timely and accurate information on the status, trends and interactions between socioeconomic and ecological processes pertaining to urban forests. In this regard, remote sensing, especially with its recent advances in sensors and data processing methods, has emerged as a premier and useful observational and analytical tool. This study summarises recent remote sensing applications in urban forestry from the perspective of three distinctive themes: multi-source, multi-temporal and multi-scale inputs. It reviews how different sources of remotely sensed data offer a fast, replicable and scalable way to quantify urban forest dynamics at varying spatiotemporal scales on a case-by-case basis. Combined optical imagery and LiDAR data results as the most promising among multi-source inputs; in addition, future efforts should focus on enhancing data processing efficiency. For long-term multi-temporal inputs, in the event satellite imagery is the only available data source, future work should improve haze-/cloud-removal techniques for enhancing image quality. Current attention given to multi-scale inputs remains limited; hence, future studies should be more aware of scale effects and cautiously draw conclusions.
Automated Classification of Trees outside Forest for Supporting Operational Management in Rural Landscapes
Authors: Bolyn Corentin , Lejeune Philippe , Michez Adrien , Latte Nicolas
Published: May 2019

Trees have important and diverse roles that make them essential outside of the forest. The use of remote sensing can substantially support traditional field inventories to evaluate and characterize this resource. Existing studies have already realized the automated detection of trees outside the forest (TOF) and classified the subsequently mapped TOF into three geometrical classes: single objects, linear objects, and ample objects. This study goes further by presenting a fully automated classification method that can support the operational management of TOF as it separates TOF into seven classes matching the definitions used in field inventories: Isolated tree, Aligned trees, Agglomerated trees, Hedge, Grove, Shrub, and Other. Using publicly available software tools, an orthophoto, and a LIDAR canopy height model (CHM), a TOF map was produced and a two-step method was developed for the classification of TOF: (1) the geometrical classification of each TOF polygon; and (2) the spatial neighboring analysis of elements and their classification into seven classes. The overall classification accuracy was 78%. Our results highlight that an automated TOF classification is possible with classes matching the definitions used in field inventories. This suggests that remote sensing has a huge potential to support the operational management of TOF as well as other research areas regarding TOF.
A New GIS-Based Model for Karst Dolines Mapping Using LiDAR; Application of a Multidepth Threshold Approach in the Yucatan Karst, Mexico
Authors: Moreno-Gómez Miguel , Liedl Rudolf , Stefan Catalin
Published: May 2019

Dolines are important features strongly influencing the outcomes of groundwater vulnerability maps, subsidence risk and land use studies. Their relationship with subsurface features like epikarst, stresses the importance of doline mapping for environmental and hydrological management strategies. Current methodologies to map dolines from elevation models apply morphometric attributes on depressions, including a depth threshold, to filter depressed areas and to define dolines. However, the use of a single threshold tends to overlook dolines located in already depressed areas. In this work a new geographic information systems (GIS)-based methodology is proposed to identify karst depressions within digital elevation models, applying a multidepth threshold approach. The method statistically classifies depression intervals to identify dolines at variable depths. The method was tested in the Yucatan karst, displaying a final accuracy of 63% after testing different parameters. The results are affected by false positives due to the impossibility of verifying by imagery 190 possible dolines in areas of dense vegetation. Nevertheless, out of 655 estimated dolines, 464 match those located by imagery giving sensitivity and precision values of 85% and 71%, respectively. Comparing this methodology against single threshold outcomes, improvement is evident in doline mapping. Notwithstanding, its application and performance with lower and higher resolution elevation models must be investigated.