bluuebunny/crossref_metadata_2025 huggingface dataset:
Test Not Talk screening for asymptomatic men
Authors: Pittrof R , McLellan J
Published: May 2007

This audit reviews the first year's experience within a rapid comprehensive sexually transmitted infection (STI) and HIV screening for asymptomatic men in a small-integrated sexual health clinic in outer London. Men requesting STI/HIV screening only were offered symptom self-assessment, blood tests for syphilis and HIV, and first void urine tests for chlamydia and gonorrhoea. Of 468 available appointments, 337 were made (72%) and 303 were kept (80%). Of the 303 attendances, 264 (87%) were first-ever attendances. Of the 303 men seen, 295 (97.4%) underwent chlamydia and gonorrhoea testing, while 246 (80.9%) were tested for syphilis and HIV. No new HIV diagnoses were made. One patient was diagnosed with late latent syphilis and one had asymptomatic gonorrhoea, while 20 (6.6%) diagnoses of chlamydia were made. We believe that Test Not Talk clinics offer a good approach to rapid screening of asymptomatic men and to meet their sexual health needs
Acoustic Comfort in Timber Frame Dwellings
Authors: Van Damme M , Blasco M , Crispin C , Huart P , Ingelaere B , Wuyts D
Published: May 2007

Timber framework has become the most common construction technique in the world for private dwellings. In Belgium, although masonry construction still constitutes the most important market share, the number of new houses with timber framework increases each year. Unfortunately the acoustic insulation of this construction type compares unfavourably with traditional masonry construction. In order to learn more about acoustic performance of timber framework houses and to compare them to the performance of traditional masonry houses, a measurement survey has been carried out, on fifteen single family dwellings with timber framework or heavyweight wood. This paper presents the results of the in situ measurements. The measurements were of façade sound insulation, sound insulation of the inner walls (horizontally and vertically) and impact noise insulation. Similar measurements also have been carried out on houses made of traditional masonry in order to compare the results. A comparison of the results collected in the laboratory and Belgian comfort criteria are also presented. Finally, results of acoustic tests in a multi-family timber construction are presented. The weaknesses of construction techniques observed during the study are discussed.
Technical Note: Transverse Vibrational Characteristics of Some Metals and Construction Materials
Authors: Surve Farhat
Published: May 2007

An experimental setup for investigation of transverse vibrational characteristics of bars is described. Characteristics of granite, marble and ceramic are investigated at varying frequencies in the free-free mode. Energy dissipation at the fundamental frequency and overtones are analyzed. Vibrational characteristics of metals like aluminium, brass and copper are examined and compared. Young's modulus for each of these materials is evaluated from their frequency response characteristics. Resonance broadening due to surface coating and changes in the medium of vibration is discussed. An algorithm is developed to simulate overtones, phase velocities, wavelengths and nodal positions, in order to verify experimental values.
Embedding {0, ½}-Cuts in a Branch-and-Cut Framework: A Computational Study
Authors: Andreello Giuseppe , Caprara Alberto , Fischetti Matteo
Published: May 2007

Embedding cuts into a branch-and-cut framework is a delicate task, especially when a large set of cuts is available. In this paper we describe a separation heuristic for {0, ½} cuts, a special case of Chvátal-Gomory cuts, that tends to produce many violated inequalities within relatively short time. We report computational results on a large testbed of integer linear programming (ILP) instances of combinatorial problems including satisfiability, max-satisfiability, and linear ordering problems, showing that a careful cut-selection strategy produces a considerable speedup with respect to the cases in which either the separation heuristic is not used at all, or all of the cuts it produces are added to the LP relaxation.
Solving the Bi-Objective Maximum-Flow Network-Interdiction Problem
Authors: Royset Johannes O. , Wood R. Kevin
Published: May 2007

We describe a new algorithm for computing the efficient frontier of the “bi-objective maximum-flow network-interdiction problem.” In this problem, an “interdictor” seeks to interdict (destroy) a set of arcs in a capacitated network that are Pareto-optimal with respect to two objectives, minimizing total interdiction cost and minimizing maximum flow. The algorithm identifies these solutions through a sequence of single-objective problems solved using Lagrangian relaxation and a specialized branch-and-bound algorithm. The Lagrangian problems are simply max-flow min-cut problems, while the branch-and-bound procedure partially enumerates s-t cuts. Computational tests reveal the new algorithm to be one to two orders of magnitude faster than an algorithm that replaces the specialized branch-and-bound algorithm with a standard integer-programming solver.
Conditions that Obviate the No-Free-Lunch Theorems for Optimization
Authors: Koehler Gary J.
Published: May 2007

Roughly speaking, the no-free-lunch (NFL) theorems state that any blackbox algorithm has the same average performance as random search. These results have largely been ignored by algorithm researchers. This paper looks more closely at the NFL results and focuses on their implications for combinatorial problems typically faced by many researchers and practitioners. We derive necessary conditions for the NFL results to hold based on common problem structures. Often it is simple to verify that these conditions are not present in the class of problems under investigation, thus providing a theoretical basis for ignoring the doleful implications of NFL giving justification for believing there might be a dominant algorithm for the problem class under study. We apply our results to three common classes of problems. We find that only trivial subclasses of these problems fall under the NFL implications.
Experiential Learning as Part of Pharmacist Supplementary Prescribing Training: Feedback from Trainees and Their Mentors
Authors: George Johnson , Bond Christine M , McCaig Dorothy J , Cleland Jennifer , Cunningham IT Scott , Diack H Lesley , Stewart Derek C
Published: May 2007

BACKGROUND:

A period of learning in practice (PLP) is an integral part of supplementary prescribing training for pharmacists in Great Britain. During the PLP, a designated medical practitioner (DMP) supervises and supports the trainee to develop competence in prescribing.

OBJECTIVE:

To evaluate the views and experiences of supplementary prescribing pharmacists and DMPs regarding the PLP and identify their perceived support needs during the PLP.

METHODS:

Prepiloted questionnaires were mailed in September 2006 to all pharmacists who had started their supplementary prescribing training at The Robert Gordon University, Aberdeen, Scotland (n = 242) and their DMPs (n = 232). Nonrespondents were sent up to 2 reminders. Responses were analyzed using descriptive and comparative statistics; responses to open questions were analyzed thematically.

RESULTS:

Responses were received from 186 (76.9%) pharmacists and 144 (62.1%) DMPs. Just over half of the pharmacists agreed/strongly agreed that they knew what was expected of them and their DMPs during the PLP, but less than half agreed/strongly agreed that it was important to communicate with pharmacist colleagues in the prescribing course. One hundred twelve (60.2%) pharmacists had their consultation skills reviewed by their DMPs during the PLP. Opportunities for professional development and teamwork were regarded as major positive experiences by both pharmacists and DMPs. Organizational, attitudinal, and time barriers were also reported. There was considerable interest among both pharmacists and DMPs for an Internet-based support network during the PLP.

CONCLUSIONS:

Information on the roles and responsibilities of pharmacists and DMPs during the PLP should be enhanced. The Internet could be a useful medium for communication during the PLP. Input from a multidisciplinary team of healthcare professionals and review of consultation videos could further enhance the PLP experience.

TRASFONDO:

Un período de aprendizaje en la práctica (PAP) es parte integral del adiestramiento de prescripción suplementaria (PS) para farmacéuticos en Gran Bretaña. Durante el PAP, un profesional médico designado (PMD) supervisa y ofrece apoyo a la persona que se adiestra para desarrollar la facultad de prescribir.
New Diagnosis of Hypertension among Celecoxib and Nonselective NSAID Users: A Population-Based Cohort Study
Authors: Wang Jingshu , Mullins C Daniel , Mamdani Muhammad , Rublee Dale A , Shaya Fadia T
Published: May 2007

BACKGROUND:

The use of nonsteroidal antiinflammatory drugs (NSAIDs) has been associated with increased blood pressure and hypertension. However, less is known about how the risk of hypertension is associated with cyclooxygenase 2 selective inhibitors (coxibs), especially celecoxib, the only coxib remaining on the market.

OBJECTIVE:

To compare the risk of incident hypertension associated with the use of celecoxib and nonselective (NS) NSAIDs.

METHODS:

A cohort study was conducted using secondary data from the GE Centricity Electronic Medical Record database, which contains millions of patient records seen by thousands of physicians across the US. The index date was defined as the date of the first NSNSAID or celecoxib prescription between January 1, 1999, and June 30, 2004. Patients were included if they were aged 18 years or older and were enrolled for at least 365 days prior to the index date. Excluded were patients who had any prior diagnosis of hypertension or pregnancy-related hypertension during the pre- or postindex date period. Also excluded were patients who had any prior prescription for antihypertensive drugs, coxibs, or NSNSAIDs. After applying inclusion/exclusion criteria, each celecoxib user was matched to 2 NSNSAID users by sex, age (±5 y), propensity score (within 0.2 SD), and number of unique drugs (±20%). Descriptive and survival analyses were conducted.

RESULTS:

The final sample consisted of 51 444 patients, of whom 17 148 were on celecoxib and 34 296 were on NSNSAIDs. Relative to NSNSAID users, patients on celecoxib had a similar rate of postexposure hypertension incidence (HR 1.013; 95% CI 0.862 to 1.190).

CONCLUSIONS:

Results from a population-based cohort analysis of electronic medical records did not show any difference in the hazard rates of incident hypertension between celecoxib and NSNSAID users.

ANTECEDENTES:

El uso de antiinflamatorios no esteroidales (AINEs) ha sido asociado a un incremento en la presión arterial y en el riesgo de hipertensión. Sin embargo, el riesgo de hipertensión asociado al uso de una nueva clase de AINEs conocidos como los inhibidores selectivos de la ciclooxigenasa II ó COX-2, es menos claro.
On the linearity of predefined and self‐anchoring Visual Analogue Scales
Authors: Hofmans Joeri , Theuns Peter
Published: May 2007

Two functional measurement studies were conducted to test the effect of two types of end anchors on the linearity of Visual Analogue Scale (VAS) data. With the first type of end anchors, participants responded to the stimuli using a VAS with predefined end anchors. With the second type, respondents defined the end anchors in terms of their own assumptions, perceptions, goals and values. The results show that VASs can be considered as linear scales and that the type of end anchors used has no effect on the linearity of the VAS data.
Infection of Internal Umbilical Remnant in Foals by Clostridium sordellii
Authors: Ortega J. , Daft B. , Assis R. A. , Kinde H. , Anthenill L. , Odani J. , Uzal F. A.
Published: May 2007

Omphalitis and the resulting septicemia contribute to perinatal mortality in several animal species. In foals, the most important causes of omphalitis are Escherichia coli and Streptococcus zooepidemicus. However to date, no information has been published about the role of Clostridium sordellii in these infections. In this paper, we describe 8 cases of perinatal mortality in foals associated with internal umbilical remnant infection by C. sordellii. The foals studied were between 12 and 21 days old at the time of death, and various breeds were represented in the group. Five of the foals were male and 3 were female. The diagnosis was established on the basis of the detection of C. sordellii by 3 methods (culture, fluorescent antibody test, and immunohistochemistry) and on gross and histopathologic findings. All foals had acute peritonitis, and the internal umbilical remnant was thickened by edema, hemorrhage, and fibrosis. A moderate amount of serosanguinous fluid with fibrin strands was present in the pericardial sac and pleural cavity. Histopathologically, the urachus and umbilical arterial walls were thickened by edema and exhibited hemorrhage, fibrin, and leukocytic infiltration. Gram-positive bacterial rods were observed in subepithelial areas of the urachus, the adventicia of umbilical arteries, and interstitium of the internal umbilical remnant. On the basis of these findings, we suggest that C. sordellii should be considered in the differential diagnosis for infections of the internal umbilical remnant in foals.
Uterine Infarctions in Cynomolgus Monkeys (Macaca fascicularis)
Authors: Trybus J. , Bain F. T. , Fikes J. D. , Carlson C. S. , O'Sullivan M. G. , Jayo M. J. , Cline J. M.
Published: May 2007

Uterine infarctions have not been reported in domestic animals, and there are few reports in the human medical literature. In a retrospective study, uterine infarctions were identified in 9 of 323 (2.8%) female cynomolgus monkeys ( Macaca fascicularis) necropsied over a 13-year period. The infarctions were grossly visible, after fixation, on the serosal surface of the uterus in 2 monkeys; the remainder were first recognized in histologic sections. Histologically, the lesions consisted of well-demarcated regions of endometrial and myometrial necrosis and of hemorrhage. All affected monkeys had histologic evidence of a previous pregnancy, which included enlarged myometrial vessels with an expanded perivascular matrix. In all monkeys with uterine infarctions, there was clinical evidence of severe systemic illness, which included trauma, diarrhea, hypovolemia, or septicemia. The major pathologic findings in affected monkeys included cutaneous or skeletal muscle necrosis (n = 5), enterocolitis (n = 4), pulmonary edema or diffuse alveolar damage (n = 3), and intestinal amyloidosis (n = 1). Histopathologic evidence of intravascular fibrin thrombi in multiple organs of 5 monkeys was consistent with a diagnosis of disseminated intravascular coagulopathy (DIC). Based on these findings, it appears that uterine infarction is an uncommon finding in cynomolgus monkeys and may occur secondary to a severe systemic illness, predisposing to DIC.
Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors
Authors: Romansik E. M. , Reilly C. M. , Kass P. H. , Moore P. F. , London C. A.
Published: May 2007

Mitotic index (MI) is an indirect measure of cell proliferation that has been demonstrated to be a strong predictor of outcome for several human and canine cancers. The purpose of this study was to evaluate the utility of MI as a predictor of biologic behavior and survival in dogs with cutaneous mast cell tumors (MCTs). Medical records from 148 dogs with histologically confirmed MCTs were reviewed. Information regarding tumor grade, local recurrence, metastatic disease, date of death/last follow-up, and outcome was obtained. The region of the tumor with the highest overall mitotic activity was chosen for evaluation, and the MI value was defined as the number of mitotic figures/10 high-power fields (400X, 2.7 mm2). A Cox proportional hazards regression model was used to compare MI with survival data. A Mann-Whitney test was used to compare MI on the basis of the development of local recurrence and metastatic disease. The MI correlated directly with tumor grade ( P < .0001). The median survival time for dogs with an MI ≤5 was significantly longer (70 months) than for those with an MI >5 (2 months), regardless of grade ( P < .001). For grade II tumors with an MI ≤5, the median survival time (MST) was 70 months, compared with 5 months for those with an MI >5 ( P < .001). For grade III tumors with an MI ≤5, the MST was not reached, compared with <2 months for those with an MI >5 ( P < .001). In conclusion, MI is a strong predictor of overall survival for dogs with cutaneous MCTs and should be included as a prognostic indicator when determining therapeutic options.
Diagnoses and Clinical Outcomes Associated with Surgically Amputated Canine Digits Submitted to Multiple Veterinary Diagnostic Laboratories
Authors: Wobeser B. K. , Kidney B. A. , Powers B. E. , Withrow S. J. , Mayer M. N. , Spinato M. T. , Allen A. L.
Published: May 2007

Amputation is commonly performed to both treat and diagnose conditions affecting the digits of dogs. Although histopathologic evaluation of these digits is routinely done, data on the prevalence and prognosis of neoplasms of the digit are scarce. The records of multiple veterinary diagnostic laboratories were searched to identify submissions of amputated digits from dogs. Four hundred twenty-eight separate submissions were reviewed for diagnosis, age, sex, limb of origin, and digits affected, and the original submitting clinics were surveyed to determine clinical outcome of the animal. No diagnosis could be agreed upon in 24 animals, and these were excluded from the study. Kaplan-Meier product-limit method was used to determine the disease-free interval and survival time. Neoplastic disease was identified in 296 of 404 submissions, with exclusively inflammatory lesions composing 108 cases. A total of 30 different neoplastic processes were identified. In 233 (77.7%) of the neoplastic cases, a malignant tumor was identified. Squamous cell carcinoma was the most commonly identified tumor ( n = 109, 36.3%), and 11 of 42 dogs for which clinical follow-up information was available developed metastatic disease. Squamous cell carcinoma of the digit appears to have a greater metastatic potential than that occurring elsewhere in the body. Other common diagnoses included melanoma ( n = 52, 17.3%), soft-tissue sarcoma ( n = 29, 9.7%), and mast cell tumor ( n = 20, 6.7%). Melanomas were associated with poor prognoses, with a median survival time of 365 days.
Immunoglobulin Crystals in Reactive Plasma Cells in a Dog
Authors: Zimmerman B. , Yamaguchi M. I. , Rush L. J.
Published: May 2007

Intracellular crystalline deposits of immunoglobulin are occasionally seen in human B-cell lymphoproliferative disorders such as multiple myeloma, chronic lymphocytic leukemia, and various forms of lymphoma. Even more uncommon is the occurrence of immunoglobulin crystals in benign plasma cells or reactive lymphocytes. Here we describe the histologic, immunohistochemical, and ultrastructural features of intracellular immunoglobulin crystals in nonneoplastic plasma cells in a chronic inflammatory lesion in a dog. Microscopically, the intracellular, nonbirefringent eosinophilic crystals were square to rectangular, 2–20 μgm long, and caused nuclear displacement to the periphery. The crystal-containing cells, as well as some of the crystals themselves, were positive for lambda light chain. Ultrastructural findings were consistent with a lattice network of protein-molecule alignment. The cause and significance of the crystals is unknown.
Tail Root Osteosarcoma in a Chipmunk (Tamias sibiricus)
Authors: Tamaizumi H. , Kondo H. , Shibuya H. , Onuma M. , Sato T.
Published: May 2007

An 8-year-old chipmunk (Tamias sibiricus) showed a mass on the tail root. Histologically, the excised mass showed proliferation of spindle-to-polyhedral cells and abundant multinucleated giant cells, with the production of neoplastic osteoid. Immunohistochemically, neoplastic cells were positive for vimentin and weakly positive for osteocalcin. Osteoid was also positive for osteocalcin. This tumor was diagnosed as a giant cell-type osteosarcoma. This is the first case report of osteosarcoma in a chipmunk.
Atrioventricular Valvular Angiectasis in Sprague-Dawley Rats
Authors: Fang H. , Howroyd P. C. , Fletcher A. M. , Diters R. W. , Woicke J. , Sasseville V. G. , Bregman C. L. , Freebern W. J. , Durham S. K. , Mense M. G.
Published: May 2007

Subendothelial heart valve angiectasis has been reported in cows, dogs, pigs, rats, mice, and in human fetuses and newborns. We observed a high incidence (62 in 208 animals examined) of spontaneous angiectasis on the atrioventricular (AV) valves in 10– to 40–week-old Sprague-Dawley rats. The angiectasis was observed predominately on the septal cusp of the right AV valve and located near the AV ostium in 57 of 62 animals. Of the remaining 5 valvular angiectases, 2 were present on the parietal cusp of the right AV valve and 3 were on the left AV valve. The angiectases were single or multiple, ranging from 40 to 300 um in diameter and were characterized by light microscopy as blood-filled dilatations lined by endothelium. Spontaneously occurring abnormalities in normal laboratory animals, such as the spontaneous valvular angiectasis reported here, need to be differentiated from drug-related lesions.
Fibroepithelial Hamartoma in a Domestic Pig
Authors: Sipos W. , Griessler F. , Schilcher F. , Stumpf I. , Pirker E. , Schmoll F.
Published: May 2007

This case report is the first description of a fibroepithelial hamartoma in a pig. The dysplasia, which covered half of the face of the newborn piglet, did not increase in relative size until the animal was euthanatized at 6 months of age. Histologic examination revealed a moderate orthokeratotic hyperkeratosis with variable degrees of epithelial proliferation. The main body of the dysplasia consisted of collagenous fibers. In addition, some proliferating small blood vessels as well as focally gathered dilated apocrine glands were evident. Given morphologic and clinical features, the diagnosis of a hamartoma seemed to be justified.
Poorly Differentiated Rectal Carcinoid in a Cow
Authors: Michishita M. , Takahashi K. , Moriya H. , Nakamura S. , Koyama H. , Sako T.
Published: May 2007

A carcinoid tumor was found as a solitary soft mass in the wall of the rectum adjacent to the anorectal junction in an adult Holstein cow. Microscopically, the tumor involved the submucosa and partly invaded the muscular layer. It consisted of a compact arrangement of a great number of large polygonal cells and a small number of small dark cells, some of which showed argyrophilia (Grimelius positive). Immunohistochemically, both types of tumor cells were positive for vimentin, keratin, and S-100 protein and weakly positive for neuron-specific enolase (NSE), whereas they were negative for some endocrine markers such as chromogranin A, insulin, glucagon, somatostatin, serotonin, adrenocorticotropic hormone, and calcitonin. Electron microscopy revealed membrane-bound secretory granules in the cytoplasm of some small dark cells. In such a poorly differentiated carcinoid, the morphologic characteristics of the small dark cells were strong evidence for the diagnosis. This is the first description of a poorly differentiated carcinoid developing in the rectum of a cow.
Hermaphroditism in a Sprague-Dawley Rat
Authors: Diters R. W. , Funk K. A. , Fang H. , Durham S. K. , Mense M. G.
Published: May 2007

A spontaneous case of unilateral true hermaphroditism was observed during the routine necropsy of a 9–week-old presumed female Sprague-Dawley rat on a repeat-dose toxicity study. There were no drug-related effects observed. True hermaphroditism is rare in rats, and despite the large numbers of rats examined annually, few cases are reported in the literature.
Genetic analysis of motor milestones attainment in early childhood
Authors: Peter Inga , Vainder Michael , Livshits Gregory
Published: May 2007

The age of attainment for four motor developmental traits, such as turning over, sitting up without support, pulling up to a standing position and walking without support, was examined in 822 children, including 626 siblings from families with 2 to 6 children, 68 pairs of dizygotic twins and 30 pairs of monozygotic twins. Correlation analysis, carried out separately for each type of sibship, showed the highest pairwise correlations in monozygotic twins and the lowest correlation in non-twin siblings for all motor milestones. Variance component analysis was used to decompose the different independent components forming the variation of the studied trait, such as genetic effect, common twin environment, common sib environment and residual factors. The results revealed that the major proportion of the total variance after adjustment for gestation age for the attainment of each motor skill, except pulling up to standing position, is explained by the common twin environment (50.5 to 66.6%), whilst a moderate proportion is explained by additive genetic factors (22.2 to 33.5%). Gestational age was found to be an important predictor of appearance of all motor milestones, affecting delay of 4.5 to 8.6 days for the attainment of the motor abilities for each week of earlier gestation. The age of attainment of the standing position was affected only by shared sibs environment (33.3% of the total variance) and showed no influence of either genetic or common twin environment. Phenotypic between trait correlations were high and significant for all studied traits (range between 0.40 and 0.67,P< 0.01 in all instances). Genetic cross correlations, however, were not easily interpreted and did not show clear variance trends among the different groups of children.
Constant multiple birth rates in the Czech Republic and the Slovak Republic until recently, 1972–1995
Authors: Imaizumi Yoko
Published: May 2007

Using vital statistics, yearly changes in the twinning and triplet rates by zygosity were investigated in the Czech Republic and the Slovak Republic during the period 1972–1995. Monozygotic (MZ) twinning rates in both countries had remained nearly constant (about 3 per 1000 total births) during that period. With a few exceptions, the dizygotic (DZ) twinning rates remained constant from 1972 to 1994, and increased in 1995 for both countries. MZ twinning rates for both countries were the lowest in Europe. As for triplet rates, overall rates increased significantly year by year in the Czech Republic, but not in the Slovak Republic. The triplet rate was significantly higher in 1995 than in the period 1972–1982 for both countries. The MZ triplet rate remained constant during that period in the Czech Republic. The trizygotic (TZ) triplet rates increased 3-fold for the Czech Republic and 4-fold for the Slovak Republic in 1972–1976 and 1992–1995. In the later period, the TZ rate was 1.5-fold higher in the Czech Republic than in the Slovak Republic. The quadruplet rate increased 2.3-fold from 2.9 per million births in 1982–1986 to 6.7 in 1992–1995 in the Czech Republic. The corresponding values were 2.7, 2.20 and 5.9-fold in the Slovak Republic. Both the Czech and the Slovak Republics were not affected by fertility drugs and assisted reproductive techniques until recently.
Individual differences in adolescent religiosity in Finland: familial effects are modified by sex and region of residence
Authors: Winter Torsten , Kaprio Jaakko , Viken Richard J , Karvonen Sakari , Rose Richard J
Published: May 2007

Data from 16-year-old Finnish twin pairs were used to estimate familial effects on religiosity and the modification of those effects by sex and residential region. The sample of 2265 twin boys and 2521 twin girls formed 779 monozygotic and 1614 dizygotic pairs, 785 of the same sex and 829 of opposite sex. We compared religiosity scores of twins living in more rural and traditional northern Finland with those living in the more urban and secular southern region. Girls had higher religiosity scores than did boys, and twins living in northern Finland had higher religiosity scores than those resident in southern Finland. Correlations for monozygotic twins were slightly higher than those for dizygotic twins, and covariance modeling found modest heritability of religiosity [11% (95% CI 0–24) for girls; 22% (95% CI 6–38) for boys], and substantial shared environmental effects [60% (95% CI 49–69) and 45% (95% CI 31–57)] among girls and boys, respectively. The correlation between shared environmental effects in boys and girls was estimated to be 0.84 (95% CI 0.73–0.99). In analyses distinguishing region of residence, girls living in southern Finland were found to have significantly higher unshared environmental effects than girls in northern Finland, while boys living in the urban south appeared to have lower shared environmental effects, and higher additive genetic effects, than boys living in the rural north.
Clarifying the relationship between religiosity and psychiatric illness: the impact of covariates and the specificity of buffering effects
Authors: Kendler Kenneth S , Gardner Charles O , Prescott Carol A
Published: May 2007

Previous analyses in a large population-based sample of female twins indicated that three dimensions of religiosity – personal devotion, personal conservatism and institutional conservatism – were, in different ways, significantly related to current depressive symptoms and substance use and lifetime psychiatric and substance use disorders. Furthermore, personal devotion, but neither personal conservatism nor institutional conservatism, buffered the depressogenic effects of stressful life events (SLEs). We here explore further these results, using linear, logistic and Cox regression models. Eight personality and six demographic variables had distinct patterns of association with the three dimensions. Personal devotion was positively associated with years of education, age, and optimism and negatively correlated with neuroticism. Personal conservatism was negatively associated with education, income, age, mastery and positively correlated with neuroticism. Institutional conservatism was negatively correlated with self-esteem and parental education. Covarying for these 14 variables produced little change in their association with psychiatric and substance use outcomes. The impact of the dimensions of religiosity differed as a function of the SLE category. High levels of both personal devotion and institutional conservatism protected against the depressogenic effects of death and personal illness. High levels of personal conservatism were associated with increased sensitivity to relationship problems. These results suggest that the association between religiosity and low risk for symptoms of depression and substance use may be in part causal. The relationship between dimensions of religiosity and response to SLEs is complex but probably of importance in clarifying the nature of the coping process.
Intrinsic and extrinsic religiousness: genetic and environmental influences and personality correlates
Authors: Bouchard Thomas J , McGue Matt , Lykken David , Tellegen Auke
Published: May 2007

This report presents findings for the Intrinsic (IR) and Extrinsic (ER) religiousness scales from the Minnesota Study of Twins Reared Apart. The scales were shown to be internally consistent, sufficiently distinct from the scales of the California Psychological Inventory and the Multidimensional Personality Questionnaire and unrelated to a number of measures of response style to justify treating them as distinct traits. The I scales also showed considerable evidence of construct validity in its correlations with religious fundamentalism and authoritarianism as assessed by the MMPI and Altemeyer's Right-Wing Authoritarianism scale. Data on IR and ER from 35 pairs of monozygotic twins reared apart (MZA) and 37 pairs of dizygotic twins reared apart (DZA) were fitted to a biometric model and demonstrated significant heritability (0.43 and 0.39), with a model containing genetic plus environmental factors fitting significantly better than a model containing only an environmental component. Twin similarity could not be explained by placement on a self-reported measure of family Moral Religious Emphasis as measured by the Family Environment Scale.
Long-term effect of placental type on anthropometrical and psychological traits among monozygotic twins: a follow up study
Authors: Gutknecht Lise , Spitz Elizabeth , Carlier Michele
Published: May 2007

The long-term effect of differences in placentation in MZ twins is a controversial subject. An effect has been clearly established for birth weight but data on psychological traits are still under debate. We studied 20 pairs of monochorionic MZ (MCMZ) and 24 pairs of dichorionic MZ (DCMZ) twins. A chorion effect was observed for Block Design (WISC-R) confirming a previous report: MC MZ co-twins were more similar that DC MZ co-twins. For anthropometrical measures, an expected effect in the opposite direction was found. No chorion effect was significant for the other variables. A follow up was undertaken 3 years later using cognitive, national academic evaluations, and personality variables. The sample included 16 pairs of MC MZ and 22 pairs of DC MZ twins. Again a chorion effect was observed on anthropometrical variables but results on the Block Design were not replicated. However, the MC MZ co-twins were more similar than the DC MZ co-twins for two other cognitive variables: Perceptual Organization Index from the WISC-R and Global Visualisation from a Belgian reasoning test. Among the personality variables only one was sensitive to a chorion effect. The discussion focuses on the need for larger samples to achieve adequate power in statistical comparisons.
Dizygotic to monozygotic twinning ratio at The Royal Women's Hospital, Melbourn 1947–1997, compared with Australian national twinning incidence
Authors: Tong Stephen
Published: May 2007

The incidence of dizygotic (Dz) twinning can be used as an index of natural human fertility. A retrospective study was done at The Royal Women's Hospital, Australia, to see whether the dizygotic to monozygotic (Mz) twinning ratio from one hospital can accurately reflect the national incidence of Dz twinning. The yearly twinning incidence from 1947–1997 was expressed as a Dz:Mz ratio, standardised for maternal age and plotted against previously published national statistics. The proportion of mothers born in Asia (of both singleton and multiples) between 1983–1997 was analysed to see whether different racial mixes might influence twinning trends. There were 5275 twins born of known sex and maternal age between 1947–1997. The agestandardised Dz:Mz ratio increased non-significantly from 1.39 in 1947 to 2.29 in 1953 (P = 0.08), underwent a significant decline to 0.73 in 1977, then remained stable until 1997 (P > 0.05). The same trends were also apparent when the data was pooled into 2-year groups with the increase from 1947/48–1953/54 becoming highly significant (P < 0.009). These trends observed in the hospital-based data were in close agreement with those found in the national statistics, with the exception of a rise in 1977–1982 only reflected in the Australia-wide data. In 1993, 2.6% of mothers were born in Asian countries; by 1997, this had risen to 10.6%. We found that the Dz:Mz ratio from one hospital closely reflects national twinning trends. Prospective studies must account for race, and would need around 200–300 twin pairs per year to minimise fluctuations of the ratio. Twin Research (2000) 3, 12–16.
Happy families: a twin study of humour
Authors: Cherkas Lynn , Hochberg Fran , MacGregor Alex J , Snieder Harold , Spector Tim D
Published: May 2007

The objective of this study was to estimate how much of an individual's appreciation of humour is influenced by genetic factors, the shared environment or the individual's unique environment. A population-based classical twin study of 127 pairs of female twins (71 monozygous (MZ) and 56 dizygous (DZ) pairs) aged 20–75 from the St Thomas' UK Adult Twin Registry elicited responses to five ‘Far Side’ Larson cartoons on a scale of 0–10. Within both MZ and DZ twin pairs, the tetrachoric correlations of responses to all five cartoons were significantly greater than zero. Furthermore, the correlations for MZ and DZ twins were of similar magnitude and in some cases the DZ correlation was greater than that of the MZ twins. This pattern of correlations suggests that shared environment rather then genetic effects contributes to cartoon appreciation. Multivariate model-fitting confirmed that these data were best explained by a model that allowed for the contribution of the shared environment and random environmental factors, but not genetic effects. However, there did not appear to be a general humour factor underlying responses to all five cartoons and no effect of age was seen. The shared environment, rather than genetic factors, explains the familial aggregation of humour appreciation as assessed by the specific ‘off the wall’ cognitive type of cartoons used in this study. Twin Research (2000) 3, 17–22.
Lifetime prevalence of mood and anxiety disorders in twin pairs discordant for schizophrenia
Authors: Lyons Michael J , Huppert Jonathan , Toomey Rosemary , Harley Rebecca , Goldberg Jack , Eisen Seth , True William , Faraone Stephen V , Tsuang Ming T
Published: May 2007

There have been long questions about the relationship of schizophrenia to other mental disorders. Lifetime DSM-III-R diagnoses of mood and anxiety disorders in twins with clinically diagnosed schizophrenia (n = 24) and their non-affected co-twins (n = 24) were compared with twins from pairs without schizophrenia (n = 3327) using a sample from the Vietnam Era Twin Registry. Schizophrenic probands had significantly elevated rates of all included disorders (bipolar disorder, major depression, dysthymia, generalized anxiety disorder, panic disorder, and PTSD) compared with controls (P < 0.01). The odd ratios comparing co-twins of schizophrenic probands with controls was greater than three for every disorder, but did not attain statistical significance. A similar pattern was observed when analyses were restricted to only monozygotic twins (n = 12). Consistent with other studies, schizophrenics appeared to have higher rates of a range of mental disorders. Our results suggest that schizophrenia per se represents a risk factor for other psychiatric disorders, but the absence of significantly elevated risk among non-schizophrenic co-twins suggested that family environmental and/or genetic factors that contribute to risk of schizophrenia do not increase the risk of mood and anxiety disorders to the same extent that the risk of these other disorders is increased by the presence of schizophrenia. Twin Research (2000) 3, 28–32.
Genetic nature of individual frailty: comparison of two approaches
Authors: Begun Alexander Z , Iachine Ivan A , Yashin Anatoli I
Published: May 2007

The traditional frailty models used in genetic analysis of bivariate survival data assume that individual frailty (and longevity) is influenced by thousands of genes, and that the contribution of each separate gene is small. This assumption, however, does not have a solid biological basis. It may just happen that one or a small number of genes makes a major contribution to determining the human life span. To answer the questions about the nature of the genetic influence on life span using survival data, models are needed that specify the influence of major genes on individual frailty and longevity. The goal of this paper is to test the nature of genetic influences on individual frailty and longevity using survival data on Danish twins. We use a new bivariate survival model with one major gene influencing life span to analyse survival data on MZ (monozygotic) and DZ (dizygotic) twins. The analysis shows that two radically different classes of model provide an equally good fit to the data. However, the asymptotic behaviour of some conditional statistics is different in models from different classes. Because of the limited sample size of bivariate survival data we cannot draw reliable conclusions about the nature of genetic effects on life span. Additional information about tails of bivariate distribution or risk factors may help to solve this problem. Twin Research (2000) 3, 51–57.
Improved indices of insulin resistance and insulin secretion for use in genetic and population studies of type2 diabetes mellitus
Authors: Jenkins Arthur B , Samaras Katherine , Carey David GP , Kelly Paul , Campbell Lesley V
Published: May 2007

Homeostasis model assessment (HOMA) provides indices of insulin secretion (β) and insulin resistance (R) derived from fasting plasma glucose (FPG) and fasting plasma insulin (FPI) levels. However, these indices could not account for a significant heritability of fasting plasma glucose (FPG) (h2 = 0.75, P < 0.01) in a group of 214 female twins. This result is consistent with a misclassification between effects due to insulin secretion and resistance in the HOMA indices. We report here evidence of such misclassification in the HOMA indices and describe a minor modification to the model which corrects it. Direct measures of insulin resistance (euglycaemic clamp) and secretion (i.v. glucose bolus) were obtained in 43 non-diabetic subjects. Heritability was estimated by statistical modelling of genetic and environmental influences in data from 214 non-diabetic female subjects. Modified HOMA (HOMA′) indices were obtained from β′ = (Ln(FPI)–c)/FPG and R′ = (Ln(FPI)–c)* FPG where c is a constant derived from regression analysis of Ln(FPI) vs FPG. Indices from both models correlated with the direct measures similarly (r = 0.63 (R), 0.49 (R′), 0.45 (β), 0.39 (β′), all P < 0.01). Directly measured insulin resistance and secretion were not significantly correlated (r = 0.13, P = 0.21). However, unmodified HOMA- and R were strongly related (r = 0.78, P < 0.0001 vs 0.13) demonstrating substantial misclassification. The relationship between β′ and R′ (r = 0.13) was not different from that between the two direct measures and significant heritability of β′ (h2 = 0.68, P < 0.01) and R′ (h2 = 0.59, P < 0.05) was evident in the twin data. The proposed modification to HOMA significantly reduces misclassification and reveals separate components of insulin resistance and insulin secretion in the heritability of FPG. Twin Research (2000) 3, 148–151.
The conjoined twins of Löwen
Authors: Blickstein Isaac
Published: May 2007

This paper discusses an unusual etching of unlike-sex conjoined twins of the syncephalus type dated 1547. The authenticity of the case is discussed in terms of the biological plausibility of such twins and in the light of mediaeval understanding of the twinning process. Unlike-sex syncephalic twins may occur as a result of dispermic fertilisation, or be an erroneous depiction of an asymmetrical anomaly of the external genitalia of a like-sex pair, mimicking the genitals of the other sex. On the other hand, the Löwen etching conforms with mediaeval beliefs that conjoined twins are divine punishment and therefore were used for ecclesiastical and perhaps commercial purposes. The historical context of the drawing, in which the relation between religion, media, and medicine satisfied the eagerness of the public for curios of Nature, is no longer valid. Thus the Löwen etching opens a window to the past from which modern medicine can be appreciated. Twin Research (2000) 3, 185–188.
Cervical length as a predictor of pre-term birth in twin gestations
Authors: Shapiro JL , Kung R , Barrett JFR
Published: May 2007

The aim of this study was to determine the predictive value of cervical length as a risk factor for spontaneous pre-term birth in twin gestations. A retrospective chart review was carried out on patients with twin pregnancies referred to our multiples' clinic. Cervical length was measured by transvaginal ultrasonography. Patients with an indicated pre-term delivery or intervention were excluded from the analysis. Outcomes included preterm delivery < 28 and < 35 weeks gestation. After extracting the data, 2 × 4 tables were constructed. Likelihood ratios were then generated for cervical lengths ≤2.0 cm, ≤2.5 cm, ≤3.0 cm, and > 3.0 cm. Because of the limited number of measurements taken < 25 weeks gestation, we elected to collapse the tables, thereby achieving more meaningful results. For measurements taken before 30 weeks gestation, a shorter cervix did predict delivery < 28 weeks gestation (likelihood ratios for cervical lengths ≤2.0 cm, ≤2.5 cm, ≤3.0 cm, and > 3.0 cm were 4.43, 1.94, 0.97, and 1.02, respectively). The probability of preterm delivery < 35 weeks gestation increased with decreasing cervical length (likelihood ratios for cervical length ≤2.0 cm, ≤2.5 cm, ≤3.0 cm, and > 3.0 cm were 2.58, 1.66, 1.38, and 0.81, respectively). A shorter cervix measured before 30 weeks gestation was a stronger predictor of preterm delivery < 28 weeks compared to < 35 weeks gestation. Cervical length was not predictive of preterm delivery if measured after 30 weeks. Cervical length is predictive of preterm delivery < 28 weeks and < 35 weeks gestation when measured before 30 weeks gestation. No trend was seen when measured after 30 weeks gestation. A prospective study is currently underway to confirm these results. Twin Research (2000) 3, 213–216.
Fetal Programming and the Leningrad Siege Study
Authors: Stanner Sara A. , Yudkin John S.
Published: May 2007

The Leningrad Siege Study investigated the relationship between decreased maternal food intake and risk factors for coronary heart disease in adult life. The study screened 169 subjects exposed to intrauterine starvation during the Siege of Leningrad (now St Petersburg) 1941–4, 192 subjects born in Leningrad before the siege and 188 subjects born concurrently with these two groups but outside the area of the siege. No difference was found between the subjects exposed to starvation in utero and during infancy in glucose tolerance [in utero: 5.2 mmol/l (95% confidence interval 5.1 to 5.3; infancy: 5.3 (5.1 to 5.5), p = 0.94], insulin concentration, blood pressure, lipid concentration or coagulation factors. The intrauterine exposed group had evidence of endothelial dysfunction by higher concentrations of von Willebrand factor and a stronger interaction between adult obesity and blood pressure. Non-systematic differences in subscapular to triceps skinfold ratio, diastolic blood pressure and clotting factors were demonstrated compared to the non-exposed groups. In conclusion, this study did not find an association between intrauterine starvation and glucose intolerance, dyslipidaemia, hypertension or cardiovascular disease in adult life. These findings differ from studies of subjects exposed to maternal starvation during the Dutch Hunger Winter. However, the dissimilar effects of exposure to the two famines may contribute to our understanding of the mechanisms of the ‘thrifty phenotype’ and support the importance of catch-up growth during early childhood, a situation that occurred in the Netherlands but not in Leningrad.