bluuebunny/crossref_metadata_2025 huggingface dataset:
With relationship at the centre: Shared mentoring as a transformative experience
Authors: Rex Liz , Staikidis Kryssi
Published: March 2017

This article explores two perspectives of doctoral advisor and student as mentor and mentee whose decade long artistic mentoring relationship reveals a multidirectional flow through which research becomes interconnected and mutually influenced. Duography is used as a narrative methodology that reframes the mentoring relationship through a series of reflections related to authors’ artistic collaborative research experiences. An intergenerational culturally based mural project becomes a springboard for future research in informal learning contexts undertaken by both scholars. Belenky’s (1997b) empowered and relational ways of knowing are values reinforced and sustained through the intersections of mentorship, teaching, and research examined. The mentoring relationship is viewed as a pivotal and generative site for mutual influence informing key components of mentoring potentially useful for others.
Cultivating potential-harvesting wisdom: An a/r/tographical illumination of mentorship
Authors: Unrath Kathleen , Ruopp Amy
Published: March 2017

As artists/teacher/researchers, our collaborative process deeply explores mentorship through a verbal and visual dialogue illuminating a sense of profound trust and its development over time. Our shared artistic process created a space for becoming. The shared experience of co-creating is echoed in the reflective exchanges that evolved as we collaboratively developed our pictorial vision of mentorship simultaneously. Our experience of co-creating, while simultaneously recalling key mentorship moments from our history together, became a site of growth, rich and complex, mapping a story of mentorship across time. This a/r/tographical research brings to light a theory of mentoring that was revealed through the process of creating.
Web mapping application of Roman Catholic Church administration in the Czech lands in the early modern period
Authors: Seemann Pavel
Published: March 2017

Reconstruction of historical spatial relationships is still a topical issue in historical geography. In this respect, the Church history has not been well explored. The parish administration in the Czech lands is evolving since the advent of Christianity in 863, and a number of reforms have passed over the centuries. Significant changes in the administration also underwent during recatholisation of the Czech lands in the 17th and 18thcentury. From this Baroque era, there are written sources which have been preserved, so they can be utilized to reconstruct historical Church administration in the form of web mapping application. The paper briefly introduces methods which were used to build a spatial database filled with historical data. However, the main outcome of this paper is to describe the creation of the web mapping application that provides visualisation of this data. Discussed are topics like cartographic project, choice of map symbols, data generalization for different levels of detail and placement of annotations. Display of cartographic data were performed using the ArcGIS platform, through a combination of map tiles and feature services that are bundled into the application template created in Web AppBuilder.
Fundamentos y perspectivas desde donde pensar la integración de la docencia y la extensión en la Universidad Nacional del Litoral
Authors: Boffelli Mariana , Sordo Sandra
Published: March 2017

El artículo que se presenta aquí pretende dar cuenta del trabajo realizado por el Área de Incorporación Curricular de la Extensión de la Secretaría de Extensión de la Universidad Nacional del Litoral y las perspectivas teóricas que sustentan un enfoque particular, como lo es la educación experiencial.En este sentido, se intenta compartir, respecto de sus distintas secciones, desde qué perspectivas y cómo se viene trabajando la integración de la extensión en el currículo universitario, partiendo de las dimensiones que dan lugar a una definición de extensión y, con relación a esto, las tensiones y desafíos que implica pararnos en un marco más amplio.Se trata de visibilizar la experiencia llevada a cabo por el área en el Plan y Acción: Fortalecimiento de la Educación Experiencial en el currículo universitario, enmarcado en el Plan de Desarrollo Institucional de la universidad (2010–2019).
¿Extensión? ¿De qué estamos hablando?
Authors: Malano Daniel , Sánchez Sonia , Elz Rubén
Published: March 2017

En este artículo se abordan algunas cuestiones que surgen a lo largo de la práctica educativa de la cátedra de Extensión Universitaria en la Universidad Nacional del Litoral, y se propone el debate y reflexión respecto de los paradigmas educativos en el sistema universitario y las concepciones teóricas y académicas que se tiene de la extensión universitaria.¿Qué y cuánto pasa inadvertido frente a nuestros ojos? Preguntas que iremos proponiendo y sustentado desde otros paradigmas científicos con la intención de no caer en simplificaciones ni definiciones sino, por el contrario, abriendo el abanico de la compleja realidad social con que se enfrenta la extensión.
Repensar las ciencias y las fronteras disciplinares. Reflexiones a partir de proyectos de extensión sobre emergencia hídrica de la Universidad del Litoral
Authors: Córdoba Anabella , Morresi María del Valle , Chialvo Patricia
Published: March 2017

Este artículo aborda la articulación interdisciplinaria e interinstitucional de docentes y estudiantes universitarios respecto de la problemática de la emergencia hídrica apartir de proyectos de extensión de interés social que se vienen desarrollando en la Universidad Nacional del Litoral desde hace varios años.Parte de comprender a la educación, en su más amplia acepción, como la transmisión de la cultura de una a otra generación, como el espacio en que el sujeto entra en contacto con la experiencia humana y la apropia, es decir aprende.Cada sujeto va haciendo suya su cultura a partir de procesos de aprendizajes significativos y situados, que le permiten el dominio progresivo de los objetos, de modos de pensar, sentir, actuar legitimados en cada contexto histórico.En este marco nos propusimos articular las ciencias duras con las ciencias sociales y jurídicas mediante la recuperación y el reconocimiento de los diferentes tránsitos, historias y desarrollos que han tenido. En este sentido, nos dimoscuenta de que en las últimas décadas, y a partir de la temática que nos convoca, el riesgo es constitutivo de la sociedad en que vivimos en la actualidad, a la que intentamos comprender desde el paradigma de la complejidad en una permanentearticulación dinámica y posible.
Inclusión curricular de la extensión en el campo de la salud: la vinculación de la universidad con la sociedad desde una nueva perspectiva
Authors: Bordoni Noemí
Published: March 2017

El marco teórico–metodológico desde el cual se formula este documento plantea que la vinculación se construye articulando las múltiples expresiones y demandas sociales con las formas de producción del conocimiento y las nuevas maneras deorganizarlos, distribuirlos e intercambiarlos en los escenarios del equipamiento social. Sus espacios naturales de intervención son aquellos donde se genera el conocimiento y se forman los recursos humanos y en ellos se la programa, ejecuta y evalúa confrontando la teoría en la práctica. En el contexto mundial, laresponsabilidad social y cívica de las universidades ha adquirido un protagonismo que la posiciona en la indelegable interacción investigación–docencia–servicio y no como un componente marginal a la investigación y a la docencia. Por lo tanto,analizar la extensión universitaria implica reflexionar sobre la práctica docente, sobre los criterios de calidad y pertinencia que se aplican al evaluar la investigación y sobre el impacto social de sus intervenciones en los escenarios donde opera.El objeto de este informe es analizar, atendiendo a ese marco, los componentes estructurales de la extensión, los procesos de su inclusión curricular y los resultados obtenidos en términos de productos e impacto producido en el campo de la salud en una experiencia desarrollada por la Universidad de Buenos Aires.
La formación en extensión como desafío. Reflexiones a partir de la determinación curricular de la extensión agropecuaria en La Plata en los años 60
Authors: Barrionuevo Cintia Analía , Garat Juan José
Published: March 2017

Según Barrientos (2002), la primera cátedra de “extensión agropecuaria” en Argentina se creó en la Universidad Nacional de La Plata en la segunda mitad de los años 60. A casi 50 años de este proceso de determinación curricular, este artículo pretende contribuir no solo a una sociohistoria institucional ydisciplinar en particular —que involucra a la entonces denominada Facultad de Agronomía de La Plata y al Instituto Nacional de Tecnología Agropecuaria— sino que, mediante la revisión bibliográfica y el análisis de documentos, comprometeuna experiencia que, influida por las teorías de la modernización y el enfoque difusionista, integraba las funciones de docencia e investigación y acercaba a los estudiantes de grado de la carrera de Ingeniería Agronómica a la práctica profesional extensionista. Consideramos que una reflexión crítica de este proceso puede abonar al debate de la formación en extensión universitaria. Buscando superar la dicotomía intramuros/extramuros con que nació la extensión, examinar la compleja génesis de un espacio político–pedagógico como éste suma elementos para poner en discusión los sentidos de las intervenciones (más allá de lo rural/agropecuario), a la vez que permite reconocer tensiones aún vigentes.
Perspectivas de la Cartografía Social, experiencias entre extensión, investigación e intervención social
Authors: Diez Tetamanti Juan Manuel , Chanampa Magali Elizabeth
Published: March 2017

Concebimos a la Cartografía Social como un proceso productivo que implica una sucesión de eventos y fases en torno a la conjunción de representaciones colectivas y transformaciones a partir de la producción de nuevos sentidosespaciales. Nuestra experiencia nos ha demostrado nuevos espacios de producción y deconstrucción de lo que entendemos como mapa, texto, proyección, e ingresamos así en una necesaria interdisciplinariedad que nos permita abordar un texto cartográfico colectivo que deconstruye la noción decartografía tradicional. Mediante un breve recorrido sobre este método y práctica, proponemos profundizar en los ejes que hacen a su aplicación. El principal objetivo teórico–metodológico del artículo es el aporte que podamos ofrecer a lainvestigación, extensión e intervención social, desde una perspectiva de comunión entre estos espacios de acción. En este sentido, consideramos la sección Intervenciones de la presente convocatoria, como un espacio acorde a los finesy contribuciones del siguiente artículo. Finalmente, cabe resaltar que a partir de la experiencia de ocho años de trabajo con Cartografía Social, en 2014 se creó la Cátedra Libre de Cartografía Social, en el seno de la Universidad Nacional de laPatagonia, a partir de la cual se han dictado múltiples cursos y talleres tanto en Argentina como en Brasil, Uruguay, Costa Rica y Mozambique.
El aprendizaje y servicio como realización de la extensión universitaria. El caso de las Prácticas Sociales Educativas en la Universidad de Buenos Aires
Authors: García Oscar Gabriel , Galli Gustavo
Published: March 2017

A partir del año 2017 las Prácticas Sociales Educativas (PSE) tendrán un carácter obligatorio en la Universidad de Buenos Aires. Esta decisión apunta a promover un importante cambio en la formación universitaria. Analizamos su origen, definición y los problemas relacionados con su incorporación curricular.Planteamos la extensión como una forma de relación entre la universidad y la sociedad, donde la estrategia pedagógica que surge son el aprendizaje y servicio solidario como elementos de formación integral de los futuros profesionales.Será entonces que, mientras el aprendizaje y servicio le dan contenido teórico a la extensión universitaria, las PSE realizan esta tradicional misión del sistema de educación superior en la Argentina. Presentaremos entonces el modelo deimplementación de estas prácticas educativas en la Universidad de Buenos Aires.
Curricularización de la extensión universitaria para la promoción de la salud en la Universidad de La Habana. Un acercamiento a su conceptualización y praxis
Authors: Mainegra Amado Batista , González Aportela Odette , Ortiz Cárdenas Tania
Published: March 2017

A partir de las exigencias actuales de la educación superior cubana en la formación integral de los estudiantes y la participación activa y consciente de estos en dar solución a las demandas de la sociedad, la Universidad de La Habana incursiona desde el curso académico 2009–2010 en el desarrollo de la curricularización de la extensión universitaria. De ahí que el objetivo del presente trabajo sea socializar la experiencia de implementación de una estrategiametodológica de integración de procesos sustantivos como contribución a la conceptualización y praxis de la curricularización de la extensión universitaria en Cuba. La estrategia metodológica propuesta contribuye a la solución deldiagnóstico inicial, caracterizado por la atomización de los procesos sustantivos universitarios y el estado deseado y necesario de integración de dichos procesos, específicamente en las acciones de promoción de salud, donde la extensiónuniversitaria desempeña un rol dinamizador y sistémico y contribuye a la formación integral del joven profesional cubano.
Reflexiones en torno a las prácticas integrales en la Universidad de la República
Authors: Tommasino Humberto , Stevenazzi Felipe
Published: March 2017

El presente artículo se propone dialogar a partir de un conjunto de reflexiones que nos surgen luego del proceso de transformación de la Universidad de la República, Uruguay, en el marco de su Segunda Reforma, que tiene como uno de sus pilares la generación de prácticas integrales, encontrando en la extensión universitaria uno de sus motores. Se entiende la integralidad como la articulación de las funciones universitarias (enseñanza, extensión e investigación), interdisciplina ydiálogo de saberes (científicos y populares). Se procurará abordar el proceso de resignificación de la extensión y el desafío de la integralidad y cómo esto puede enriquecer la formación universitaria y aportar a la transformación de lo que implicahacer universidad.
Extensión, investigación e integralidad en la Facultad de Arquitectura, Diseño y Urbanismo de la Universidad de la República
Authors: Lago Guillermo , Rimbaud Tatiana , Venegas Marcela
Published: March 2017

El Servicio de Investigación y Extensión (SIE) de la Facultad de Arquitectura, Diseño y Urbanismo (FADU) de la Universidad de la República (UdelaR), Uruguay, tiene como cometido apoyar, promover y gestionar los asuntos relacionados con dos de las tres funciones universitarias, y ha asumido el rol de promotor dentro de la Facultad de las prácticas integrales. La integralidad es entendida como la articulación de la enseñanza, investigación y extensión en la formación de estudiantes, vinculados con actores no universitarios buscando contribuir a la resolución de problemáticas preferentemente desde abordajes interdisciplinarios.Este artículo hace foco en la convocatoria “Yo soy EFI” 2015–2016, donde se pretende, a partir de la autoidentificación con los Espacios de Formación Integral (EFI) desarrollados en FADU, orientar los esfuerzos para apoyar el desarrollo y difusión de los mismos. Estas convocatorias, las publicaciones,seminarios, y demás iniciativas que se han desarrollado desde el SIE implican pequeños pasos hacia un modelo de universidad necesario.
La extensión universitaria y el nuevo plan de estudios de la carrera de Abogacía en la Universidad Nacional de La Plata
Authors: Furfaro Cristian
Published: March 2017

El objetivo del presente artículo es reflexionar en torno a la inclusión de la extensión universitaria en el nuevo plan de estudios de la carrera de Abogacía de la Facultad de Ciencias Jurídicas y Sociales (FCJyS) de la Universidad Nacionalde La Plata (UNLP). Iniciaremos este recorrido con una breve descripción de algunas características de la extensión universitaria en la FCJyS, su relación con el plan de estudios vigente y el proceso de sanción del nuevo plan de estudios.Posteriormente, estableceremos algunas cuestiones teóricas que guiarán el análisis de los documentos elaborados por la FCJyS y que nos permitirán reflexionar sobre los fundamentos esgrimidos para incluir la extensión universitaria en el nuevoplan de estudios, los principios sostenidos y las decisiones que se tomaron.Finalmente, explicitaremos algunas cuestiones respecto de la tensión que existe en el mundo del Derecho entre prácticas profesionales y extensión universitaria.
EFFECT OF THE BANK OF RISK CAPITAL ADEQUACY RATIO (CAR) ON FOREIGN EXCHANGE NATIONAL PRIVATE BANKS
Authors: Herizon Herizon
Published: March 2017

The purpose of the research is to determine LDR, IPR, NPL, APB, IRR, PDN, BOPO and FBIR simultaneously and partially have significant influence toward Capital Adequacy Ratio (CAR). Population were the On Foreign Exchange National Private Banks. Sampling technique is purposive sampling so that the selected Bank were PT. Bank ICBC Indonesia, Tbk, PT. Bank Permata, Tbk ,PT. Bank UOB Indonesia, Tbk , PT. Bank. Data collected by the methods of documentation and analysis were performed by linear multiple regression analysis technique.Results shows that LDR, IPR, NPL, APB, IRR, PDN BOPO, and FBIR simultaneously have significant effect toward CAR ratio On Foreign Exchange National Private Banks. Partially LDR ratio significantly has a positive effect on CAR ratio On Foreign Exchange National Private Banks and Partially BOPO ratio significantly has a negative effect on CAR ratio On Foreign Exchange National Private Banks. Meanwhile IPR , NPL, and PDN has a positive effect but insignificant toward CAR  ratio On Foreign Exchange National Private Banks. On the other side, APB, IRR and FBIR have negative effect but insignificant toward CAR ratio On Foreign Exchange National Private Banks.
PENGARUH CITRA MEREK, IKLAN DAN PERSEPSI KUALITAS TERHADAP NIAT BELI SEPEDA POLYGON DI BOJONEGORO
Authors: Marta Laila Saleh
Published: March 2017

This Globalization era led to the development of various field. One of the development is visible si the field of transport. One of the menas of transportused by the public at the time was a bike. Today the bike has been converted as a means of sport. For some young people often used as a hobby. The purpose of this research is to test and analyze the effect of Brand Image, Advertising and Perceived Quality for Purchase Intention Polygon Bike in Bojonegoro. Independent variable that supports this research is Brand Image, Advertising and Perceived Quality, mean while its dependent variable is Purchase Intention. The size of respondent in this research were 100 in Bojonegoro.Sampling technique used in this research is Judgement Sampling Technique Analysis used is multiple linear regression and using analysis tool of SPSS version 16.00. The result of this research is Brand Image, Advertising and Perceived Quality has significant and positive influence on Purchase Intention.
PENGARUH STRUKTUR KEPEMILIKAN, STRUKTUR AKTIVA, LIKUIDITAS, RISIKO BISNIS, KEBIJAKAN DIVIDEN, UKURAN PERUSAHAAN, DAN PROFITABILITAS TERHADAP STRUKTUR MODAL PADA INDUSTRI HOTEL, RESTORAN DAN PARIWISATA
Authors: Jati Agustinus Kismet Nugroho
Published: March 2017

The determination of capital structure policy becomes important in the hotels, restaurants and tourism industry in Indonesia. This industry environment has a fairly high business fluctuations because the product that being offered is a product that requires a large capital. The firms in this industry which in have capital intensive, but also have a quite high business risks. On the other hand, firms also need to take care of the capital structure that will be used. It is the goal of this studies so that it can be the information for the firm to determine the optimal capital structure. The results of this study are simultaneously factors managerial ownership structure, asset structure, liquidity, business risk, dividend policy, the size and profitability of the firm has no significant effect on the capital structure of the firm, while only partially profitability factor that showed a significant negative effect on capital structure. This means there is a tendency of firms in this industry in Indonesia to use funding from internal sources to finance its business expansion.
KINERJA RASIO KEUANGAN UNTUK MEMPREDIKSI KONDISI FINANCIAL DISTRESS PADA PERUSAHAAN JASA DI BURSA EFEK INDONESIA PERIODE 2009-2014
Authors: Muazaroh Muazaroh
Published: March 2017

Identifying financial distress condition is important because it can be an early warning system before bankcruptcy. This condition can be predicted using models that have developed by many researchers. The purpose of this research is to describe and analyze the effect of the return on assets, current ratio, debt to equity ratio and total asset turnover towards condition of financial distress in service sector listed in Indonesian Stock Exchange (IDX) in the year 2009-2014. The data analysis technique is logistic regression. The sample consist of 60 data observed of the firms with positive earning before tax for the two consecutive years and 60 data observed of the firms with negative earning before tax for the two consecutive years. The result of this research shows thatreturn on asset significantly affects to condition of company financial distress. Whereas debt to equity ratio, current ratio and total asset turnover do not significantly influenceto condition of company financial distress.So, companies should pay attention to productivity in the future to maintain the effectiveness of the management.
PENGARUH KEPERCAYAAN, KEAMANAN, PERSEPSI RISIKO, SERTA KESADARAN NASABAH TERHADAP ADOPSI E-BANKING DI BANK BRI SURABAYA
Authors: Afghani Moh Faqih , Yulianti Emma
Published: March 2017

The purpose of this research was to analyze the effect of each-each variable, trust, security, perceived risk, and awareness to adoption e-banking on bank BRI customers in Surabaya. The process of data collection used convenience sampling method by purpose taking customers that used e-banking BRI in Surabaya. From 90 questionnaires distributed, there were 90 questionnaires returned. The method analysis used the program Spss 16.00. The result showed that three proposed hypothesis was accepted except two hypothesis relationship between security to adoption and perceived risk to adoption had no significant relationship. The management implication and suggestions for the banks as e-banking services providers were also discussed at the end of this research.
Review of London and the Making of Provincial Literature
Authors: Wigginton Caroline
Published: March 2017

Book review.
Review of Dante and the Dynamics of Textual Exchange
Authors: Fritz-Morkin Maggie
Published: March 2017

Book review
10.1 Back matter
Authors: O'Sullivan Daniel
Published: March 2017

10.1 Back matter
Wikis for group work: Encouraging transparency, benchmarking, and feedback
Authors: Abdekhodaee Amir , Chase Anne-Marie , Ross Bella
Published: March 2017

Technology is recognised as playing a part in the changing landscape in higher education; altering delivery modes and providing flexible opportunities for learning. Research into the use of wikis has shown that they provide many opportunities for student learning and the development of twenty-first century skills, however, there has been limited success in their use for collaboration. In this exploratory research, we report on a group wiki project in an engineering management unit at an Australian university. A wiki was introduced to replace the existing group report assessment to add transparency to the task. Each group had their own wiki and students were required to provide feedback to other group wikis which enabled transparency of students’ report development and group progress. The research aim was to investigate student perceptions of using a wiki. Students found the wikis helpful for benchmarking their activity against their peers. Students stated that peer feedback had improved their work; however, much of the feedback given by peers was too brief to be constructive, and provided too late to be useful in guiding their work. This paper will be of interest to academics interested in using wikis in their teaching to develop feedback, transparency, and benchmarking.
Effects of tagcloud-anchored group discussions on pre-service teachers’ collaborative knowledge construction
Authors: Lin Shu-Yuan , Xie Ying
Published: March 2017

Group discussions are critical for students constructing new understanding and knowledge in both classroom and distance education. Tagclouds can provide an intuitive overview about the group’s collective knowledge and could potentially be used as an anchor for group discussions. The effect of using tagclouds as anchors for group discussions was examined. Thirty-two pre-service teachers were randomly assigned into six groups, and they blogged for five weeks. At the end of the blogging activity, three groups were randomly selected to participate in tagcloud-anchored discussions. Evidence of knowledge construction was collected from participants’ concept maps, individual blog tags and group tagclouds. The result indicates tagcloud-anchored group discussions facilitated and enhanced the quality of knowledge construction as exhibited in their concept maps.
Tracking reading strategy utilisation through pupillometry
Authors: Wong Aaron Y. , Moss Jarrod , Schunn Christian D.
Published: March 2017

Explicit reading strategies help low-knowledge readers make the inferences necessary to comprehend expository texts. Self-explanation is a particularly effective strategy, but it is challenging to monitor how well a reader is applying self-explanation without requiring the reader to externalise the self-explanations being generated. Studies have shown that different reading strategies vary in the amount of cognitive control required as well as the engagement of brain regions involved in internally-directed attention. Pupil diameter is related to task engagement and cognitive control via the brain’s locus coeruleus-norepinephrine system. Therefore, pupil diameter could be a method to unobtrusively measure a reader’s use of self-explanation. The current study assessed whether pupil diameter can be used to distinguish between the use of different reading strategies and whether it is linked to the quality and effectiveness of the strategy in terms of learning gains. Participants reread, paraphrased, and self-explained texts while pupil diameter was recorded, and completed comprehension tests. Average pupil diameter differed between all three reading strategies, and pupil diameter was related to learning gains and the quality of strategy use. The results suggest that pupil diameter could be used to track effective reading strategy utilisation.
Editorial
Authors: Hedberg John G
Published: March 2017

This issue appears at a time when Higher Education is going through ashakeup in Australia. At the time of compiling this issue, there has justbeen announced an inquiry into the ways new technology can improveeducation.
The optimal exercise intensity for the unbiased comparison of thermoregulatory responses between groups unmatched for body size during uncompensable heat stress
Authors: Ravanelli Nicholas , Cramer Matthew , Imbeault Pascal , Jay Ollie
Published: March 2017

We sought to identify the appropriate exercise intensity for unbiased comparisons of changes in rectal temperature (ΔTre) and local sweat rates (LSR) between groups unmatched for body size during uncompensable heat stress. Sixteen males vastly different in body morphology were separated into two equal groups [small (SM): 65.8 ± 6.2 kg, 1.8 ± 0.1 m2; large (LG): 100.0 ± 13.1 kg, 2.3 ± 0.1 m2], but matched for sudomotor thermosensitivity (SM: 1.3 ± 0.6; LG: 1.1 ± 0.4 mg·cm−2·min−1·°C−1). The maximum potential for evaporation (Emax) for each participant was assessed using an incremental humidity protocol. On separate occasions, participants then completed 60 min of cycling in a 35°C and 70% RH environment at (1) 50% of VO2max, (2) a heat production (Hprod) of 520 W, (3) Hprod relative to mass (6 W·kg−1), and (4) Hprod relative to mass above Emax (3 W·kg−1>Emax). Emax was similar between LG (347 ± 39 W, 154 ± 15 W·m−2) and SM (313 ± 63 W, 176 ± 34 W·m−2, P > 0.12). ΔTre was greater in SM compared to LG at 520 W (SM: 1.5 ± 0.5; LG 0.8 ± 0.3°C, P < 0.001) and at 50% of VO2max (SM: 1.4 ± 0.5; LG 0.9 ± 0.3°C, P < 0.001). However, ΔTre was similar between groups when Hprod was either 6 W·kg−1 (SM: 0.9 ± 0.3; LG 0.9 ± 0.2°C, P = 0.98) and 3 W·kg−1>Emax (SM: 1.4 ± 0.5; LG 1.3 ± 0.4°C, P = 0.99). LSR was similar between LG and SM irrespective of condition, suggesting maximum LSR was attained (SM: 1.10 ± 0.23; LG: 1.07 ± 0.35 mg·cm−2·min−1, P = 0.50). In conclusion, systematic differences in ΔTre and LSR between groups unmatched for body size during uncompensable heat stress can be avoided by a fixed Hprod in W·kg−1 or W·kg−1>Emax.
Taking IUPAC Literally: Woodward’s Pure and Applied Chemistry Words
Authors: Seeman Jeffrey I.
Published: March 2017

According to IUPAC, “
Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques
Authors: Nimitvilai Sudarat , Uys Joachim D. , Woodward John J. , Randall Patrick K. , Ball Lauren E. , Williams Robert W. , Jones Byron C. , Lu Lu , Grant Kathleen A. , Mulholland Patrick J.
Published: March 2017

Cognitive impairments, uncontrolled drinking, and neuropathological cortical changes characterize alcohol use disorder. Dysfunction of the orbitofrontal cortex (OFC), a critical cortical subregion that controls learning, decision-making, and prediction of reward outcomes, contributes to executive cognitive function deficits in alcoholic individuals. Electrophysiological and quantitative synaptomics techniques were used to test the hypothesis that heavy drinking produces neuroadaptations in the macaque OFC. Integrative bioinformatics and reverse genetic approaches were used to identify and validate synaptic proteins with novel links to heavy drinking in BXD mice. In drinking monkeys, evoked firing of OFC pyramidal neurons was reduced, whereas the amplitude and frequency of postsynaptic currents were enhanced compared with controls. Bath application of alcohol reduced evoked firing in neurons from control monkeys, but not drinking monkeys. Profiling of the OFC synaptome identified alcohol-sensitive proteins that control glutamate release (e.g., SV2A, synaptogyrin-1) and postsynaptic signaling (e.g., GluA1, PRRT2) with no changes in synaptic GABAergic proteins. Western blot analysis confirmed the increase in GluA1 expression in drinking monkeys. An exploratory analysis of the OFC synaptome found cross-species genetic links to alcohol intake in discrete proteins (e.g., C2CD2L, DIRAS2) that discriminated between low- and heavy-drinking monkeys. Validation studies revealed that BXD mouse strains with theDallele at theC2cd2linterval drank less alcohol thanBallele strains. Thus, by profiling of the OFC synaptome, we identified changes in proteins controlling glutamate release and postsynaptic signaling and discovered several proteins related to heavy drinking that have potential as novel targets for treating alcohol use disorder.

SIGNIFICANCE STATEMENTClinical research identified cognitive deficits in alcoholic individuals as a risk factor for relapse, and alcoholic individuals display deficits on cognitive tasks that are dependent upon the orbitofrontal cortex (OFC). To identify neurobiological mechanisms that underpin OFC dysfunction, this study used electrophysiology and integrative synaptomics in a translational nonhuman primate model of heavy alcohol consumption. We found adaptations in synaptic proteins that control glutamatergic signaling in chronically drinking monkeys. Our functional genomic exploratory analyses identified proteins with genetic links to alcohol and cocaine intake across mice, monkeys, and humans. Future work is necessary to determine whether targeting these novel targets reduces excessive and harmful levels of alcohol drinking.
HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation
Authors: Chivero Ernest T. , Guo Ming-Lei , Periyasamy Palsamy , Liao Ke , Callen Shannon E. , Buch Shilpa
Published: March 2017

Neuroinflammation associated with HIV-1 infection is a problem affecting ∼50% of HIV-infected individuals. NLR family pyrin domain containing 3 (NLRP3) inflammasome has been implicated in HIV-induced microglial activation, but the mechanism(s) remain unclear. Because HIV-1 Transactivator of Transcription (Tat) protein continues to be present despite antiretroviral therapy and activates NF-kB, we hypothesized that Tat could prime the NLRP3 inflammasome. We found a dose- and time-dependent induction of NLRP3 expression in microglia exposed to Tat compared with control. Tat exposure also time-dependently increased the mature caspase-1 and IL-1β levels and enhanced the IL-1β secretion. Thesein vitrofindings were validated in archival brain tissues from Simian Immunodeficiency Virus (SIV)-infected and uninfected rhesus macaques. Further validation of NLRP3 primingin vivoinvolved administration of lipopolysaccharide (LPS) to HIV transgenic (Tg) rats followed by assessment of IL-1β mRNA expression and inflammasome activation (ASC oligomers and mature IL-1β). Intriguingly, LPS potentiated upregulation of IL-1β mRNA and inflammasome activation in HIV-Tg rats compared with the wild-type controls. Interestingly, we found an inverse relationship in the expression of NLRP3 and its negative regulator, miR-223, suggesting a miR-223-mediated mechanism for Tat-induced NLRP3 priming. Furthermore, blockade of NLRP3 resulted in decreased IL-1β secretion. Collectively, these findings suggest a novel role of Tat in priming and activating the NLRP3 inflammasome. Therefore, NLRP3 can be envisioned as a therapeutic target for ameliorating Tat-mediated neuroinflammation.

SIGNIFICANCE STATEMENTDespite successful suppression of viremia with increased longevity in the era of combined antiretroviral therapy, chronic inflammation with underlying neurocognitive impairment continues to afflict almost 50% of infected individuals. Viral, bacterial, and cellular products have all been implicated in promoting the chronic inflammation found in these individuals. Understanding the molecular mechanism(s) by which viral proteins such as HIV-1 Transactivator of Transcription (Tat) protein can activate microglia is thus of paramount importance. Herein, we demonstrate a novel role of Tat in priming and activating NLR family pyrin domain containing 3 (NLRP3) inflammasomes in microglial cells and in HIV-Tg rats administered lipopolysaccharide. Targeting NLRP3 inflammasome pathway mediators could thus be developed as therapeutic interventions to alleviate or prevent neuroinflammation and subsequent cognitive impairment in HIV-positive patients.
Neural Architecture for Feature Binding in Visual Working Memory
Authors: Schneegans Sebastian , Bays Paul M.
Published: March 2017

Binding refers to the operation that groups different features together into objects. We propose a neural architecture for feature binding in visual working memory that employs populations of neurons with conjunction responses. We tested this model using cued recall tasks, in which subjects had to memorize object arrays composed of simple visual features (color, orientation, and location). After a brief delay, one feature of one item was given as a cue, and the observer had to report, on a continuous scale, one or two other features of the cued item. Binding failure in this task is associated with swap errors, in which observers report an item other than the one indicated by the cue. We observed that the probability of swapping two items strongly correlated with the items' similarity in the cue feature dimension, and found a strong correlation between swap errors occurring in spatial and nonspatial report. The neural model explains both swap errors and response variability as results of decoding noisy neural activity, and can account for the behavioral results in quantitative detail. We then used the model to compare alternative mechanisms for binding nonspatial features. We found the behavioral results fully consistent with a model in which nonspatial features are bound exclusively via their shared location, with no indication of direct binding between color and orientation. These results provide evidence for a special role of location in feature binding, and the model explains how this special role could be realized in the neural system.

SIGNIFICANCE STATEMENTThe problem of feature binding is of central importance in understanding the mechanisms of working memory. How do we remember not only that we saw a red and a round object, but that these features belong together to a single object rather than to different objects in our environment? Here we present evidence for a neural mechanism for feature binding in working memory, based on encoding of visual information by neurons that respond to the conjunction of features. We find clear evidence that nonspatial features are bound via space: we memorize directly where a color or an orientation appeared, but we memorize which color belonged with which orientation only indirectly by virtue of their shared location.
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue
Authors: Hui Xiaoyan , Zhang Mingliang , Gu Ping , Li Kuai , Gao Yuan , Wu Donghai , Wang Yu , Xu Aimin
Published: March 2017

Adipose tissue inflammation, characterized by augmented infiltration and altered polarization of macrophages, contributes to insulin resistance and its associated metabolic diseases. The NAD+‐dependent deacetylase SIRT1 serves as a guardian against metabolic disorders in multiple tissues. To dissect the roles of SIRT1 in adipose tissues, metabolic phenotypes of mice with selective ablation of SIRT1 in adipocytes and myeloid cells were monitored. Compared to myeloid‐specific SIRT1 depletion, mice with adipocyte‐selective deletion of SIRT1 are more susceptible to diet‐induced insulin resistance. The phenotypic changes in adipocyte‐selective SIRT1 knockout mice are associated with an increased number of adipose‐resident macrophages and their polarization toward the pro‐inflammatory M1 subtype. Mechanistically, SIRT1 in adipocytes modulates expression and secretion of several adipokines, including adiponectin, MCP‐1, and interleukin 4, which in turn alters recruitment and polarization of the macrophages in adipose tissues. In adipocytes, SIRT1 deacetylates the transcription factor NFATc1 and thereby enhances the binding of NFATc1 to the Il4 gene promoter. These findings suggest that adipocyte SIRT1 controls systemic glucose homeostasis and insulin sensitivity via the cross talk with adipose‐resident macrophages.
A validated HPLC–MS/MS method for the quantification of supinoxin in rat plasma and its application to pharmacokinetic study
Authors: Jeong Jong-Woo , Seol Yun-Hwan , Hyun Hun-Chan , Kim Hye-Rim , Lee Jong-Hwa , Gong Young-Dae , Kang Nam Sook , Koo Tae-Sung
Published: March 2017

A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for the quantification of an anticancer drug, supinoxin (RX-5902), in rat plasma. Following precipitation pretreatment using 0.1% formic acid in acetonitrile, separation was performed using a reverse phase liquid chromatography column packed with C18 (3.5 μm, 2.1 × 50 mm) along with a mobile phase of 0.1% formic acid in distilled water and 0.1% formic acid in acetonitrile at a flow rate of 0.3 mL min−1. Detection was achieved using MS/MS by multiple reaction monitoring via an electrospray ionization source at mass/charge transitions of m/z 442.30 → 223.30 for supinoxin and m/z 430.08 → 223.20 for the internal standard DGG-200064. This method demonstrated a linear standard curve (r = 0.9980) over a supinoxin concentration range of 0.0005–1 μg mL−1, as well as intra- and inter-assay precisions below 7.08% and 13.74%, respectively, and an accuracy of 1.15–4.50%. The matrix effect, recovery, and process efficiency were 93.63%, 99.70%, and 93.33%, respectively. Thus, a sensitive and reliable LC–MS/MS method was developed and validated for the quantification of supinoxin in rat plasma. This method was successfully applied to the evaluation of pharmacokinetic studies after single intravenous and oral administration of 1 mg kg−1 supinoxin in rats.
A dabigatran-antidótum, az intravénás idarucizumab első hazai alkalmazása
Authors: Driesz Lajos , Barabás Éva , Bodócs Ildikó , Szántó Zoltán , Herr György , Bencsik Gábor , Pál László , Borbola József
Published: March 2017

Abstract:

At present, the direct thrombin inhibitor dabigatran is the only one amongst the new direct anticoagulants which has an effective, specific reversal agent. The novel agent idarucizumab is a humanized, monoclonal antibody fragment binds to dabigatran within minutes thereby offers an opportunity to induce a safe, long-lasting reverse of the anticoagulant effects of dabigatran. The authors describe the first use of idarucizumab in Hungary (23. 05. 2016) in an old female patient with non-valvular paroxysmal atrial fibrillation of high stroke risk-score and renal dysfunction who was taking dabigatran (2 x 110 mg/day) when an acute abdomen developed requiring emergency cholecystectomy. Patient received the antidote (idarucizumab 2 x 2.5 g/50 ml iv.) two hours before the surgical intervention, and she did not have any uncontrollable, life-threatening bleeding during the surgery. The high activated partial thromboplastin time relating to anticoagulative influence before the surgery normalized completely after administration of the antidote. Antagonizing dabigatran with idarucizumab was feasible and safe without any side effects. The patient received dabigatran therapy again after her recovery. Orv. Hetil., 2017, 158(10), 387–392.
Teoretyczne i praktyczne zagadnienia związane z pięciodniowym terminem na złożenie wniosku do USC w celu rejestracji kanonicznego małżeństwa (art. 10 ust. 1 pkt 3 Konkordatu)
Authors: Kroczek Piotr
Published: March 2017

The Concordat between the Holy See and the Republic of Poland was signed in 1993, but ratified in 1998. Year 2013 marks the 15th anniversary of coming into effect of the bilateral agreement. It is a good opportunity to evaluate its provisions. The paper aims to present one of the pieces of evidence from art. 10 sect. 1 no. 3 of the Concordat, namely, the evidence for registering canonical marriage in the State Civil Registry so that the marriage would be a subject to such effects as a marriage contracted according to Polish law. From the interpretation of the provision in question and application of its norms there arise some theoretical and practical problems. The author tries to solve them and give some postulates de lege ferenda so as to make the law more clear.
The celebrant of the Holy Sacrament of the Eucharist. Rules and canonical norms of the Orthodox Church
Authors: Mititelu Cătălina
Published: March 2017

This review  presents the canonical legislation text of the Orthodox Church, from the first millennium – corroborated with the text of the typiconal guidelines  made and published over the centuries in this part of this ecumenical Christian world – concerning the celebration of the Divine Sacrament of the Eucharist and, ipso facto, its celebrant. Thus an opportunity is created to offer to the reader (canonist or theologian) some eloquent testimonies of the liturgical-canonical Tradition of this Church, which is part of the common liturgical-canonical heritage of the ecumenical Church of  the first millennium.
Paraoxonase: The Universal Factor of Antioxidant Defense in Human Body
Authors: Borovkova E. I. , Antipova N. V. , Korneenko T. V. , Shakhparonov M. I. , Borovkov I. M.
Published: March 2017

The paraoxonase (PON) gene family includes three members: PON1, PON2, and PON3 aligned in tandem on chromosome 7 in humans. All PON proteins share considerable structural homology and have the capacity to protect cells from oxidative stress; therefore, they have been implicated in the pathogenesis of several inflammatory diseases, particularly atherosclerosis. Increased production of reactive oxygen species as a result of decreased activities of mitochondrial electron transport chain complexes plays a role in the development of many inflammatory diseases, including atherosclerosis. PON1 and PON3 proteins can be detected in plasma and reside in the high-density lipoprotein fraction and protect against oxidative stress by hydrolyzing certain oxidized lipids in lipoproteins, macrophages, and atherosclerotic lesions. Paraoxonase 2 (PON2) possesses antiatherogenic properties and is associated with lower ROS levels. PON2 is involved in the antioxidative and anti-inflammatory response in intestinal epithelial cells. In contrast to PON1 and PON3, PON2 is cell-associated and is not found in plasma. It is widely expressed in a variety of tissues, including the kidney, and protects against cellular oxidative stress. Overexpression of PON2 reduces oxidative status, prevents apoptosis in vascular endothelial cells, and inhibits cell-mediated low density lipoprotein oxidation. PON2 also inhibits the development of atherosclerosis, via mechanisms involving the reduction of oxidative stress. In this review we explore the physiological roles of PON in disease development and modulation of PONs by infective (bacterial, viral) agents.