bluuebunny/crossref_metadata_2025 huggingface dataset:
JAK/BCL2 inhibition acts synergistically with LSD1 inhibitors to selectively target ETP-ALL
Authors: Benyoucef Aissa , Haigh Katharina , Cuddihy Andrew , Haigh Jody J.
Published: October 2022

ETP-ALL (Early T cell Progenitor Acute Lymphoblastic Leukemia) represents a high-risk subtype of T cell acute lymphocytic leukemia (T-ALL). Therapeutically, ETP-ALL patients frequently relapse after conventional chemotherapy highlighting the need for alternative therapeutic approaches. Using our ZEB2Tg ETP-ALL mouse model we previously documented the potential utility of the catalytic LSD1 inhibitor (GSK2879552) for treating mouse/human ETP-ALL. However, this approach proved to be inefficient, especially in killing human LOUCY cell ETP-ALL xenografts in vivo. Here we have revealed the novel involvement of ZEB2/LSD1 complexes in repressing the intrinsic apoptosis pathway by inhibiting the expression of several pro-apoptotic proteins such as BIM (BCL2L11) as a major driver for ETP-ALL survival. Treatment with LSD1i (particularly with the steric inhibitor SP2509) restored the expression of ZEB2/LSD1 pro-apoptotic BIM (BCL2L11) target. In combination with a JAK/STAT pathway inhibitor (JAKi, Ruxolitinib) or with a direct inhibitor of the anti-apoptotic BCL2 protein (BCL2i, ABT-199) resistance of human and mouse ETP-ALL to LSD1i was reversed. This new combination approach efficiently inhibited the growth of human and mouse ETP-ALL cells in vivo by enhancing their differentiation and triggering an apoptotic response. These results set the stage for novel combination therapies to be used in clinical trials to treat ETP-ALL patients.
The association of serum vitamin D with incident diabetes in an African American population
Authors: Joseph Joshua J. , Langan Susan , Lunyera Joseph , Kluwe Bjorn , Williams Amaris , Chen Haiying , Sachs Michael C. , Hairston Kristin G. , Bertoni Alain G. , Hsueh Willa A. , Golden Sherita H.
Published: October 2022

Background

Incident diabetes risk is inversely proportional to 25-hydroxyvitamin D [25(OH)D] levels among non-Hispanic white but is unclear among African American (AA) populations. Serum 25(OH)D2 may be an important component of total 25(OH)D among AA populations due to higher levels of melanin.

Objective

To assess the association of serum 25(OH)D with incident diabetes among AAs and stratify by detectable 25(OH)D2.

Design

Serum 25(OH)D2 and 25(OH)D3 were collected from 2000 to 2004 among AA participants in the Jackson Heart Study. A cosinor model was used to adjust for the seasonality of 25(OH)D3; 25(OH)D3 and 25(OH)D2 were combined to ascertain total 25(OH)D. Incident diabetes (fasting glucose ≥126 mg/dl, use of diabetes drugs, or HbA1c ≥6.5%) was assessed over 12 years among adults without diabetes at baseline. Participants with missing baseline covariates or diabetes follow-up were excluded. Hazard ratios (HR) were estimated using Cox modeling, adjusting for age, sex, education, occupation, smoking, physical activity, alcohol use, aldosterone, and body-mass index.

Results

Among 3311 adults (mean age 53.3 years, 63% female) 584 participants developed diabetes over a median of 7.7 years. After adjustment, 25(OH)D ≥20 compared to <12 ng/ml was associated with a HR 0.78 (95% CI: 0.61, 1.00). Among participants with detectable 25(OH)D2 and 25(OH)D3 (n = 1671), 25(OH)D ≥ 20 ng/ml compared to <12 ng/ml was associated with a 35% (HR 0.65, 95% CI: 0.46, 0.91) lower risk of diabetes.

Conclusions

Higher levels of 25(OH)D may be protective against the development of diabetes among AA individuals, particularly among those with detectable 25(OH)D2 and 25(OH)D3.
A Posteriori dietary patterns, insulin resistance, and diabetes risk by Hispanic/Latino heritage in the HCHS/SOL cohort
Authors: Maldonado Luis E. , Sotres-Alvarez Daniela , Mattei Josiemer , Daviglus Martha L. , Talavera Gregory A. , Perreira Krista M. , Van Horn Linda , Mossavar-Rahmani Yasmin , LeCroy Madison N. , Gallo Linda C. , Albrecht Sandra S.
Published: October 2022

Objective

We examined links among dietary patterns (DPs), insulin resistance (IR), and diabetes risk by heritage in the Hispanic Community Health Study/Study of Latinos.

Methods

Hispanics/Latinos of Cuban, Dominican, Mexican, Puerto Rican, Central American, and South American heritage aged 18–74 years and diabetes-free completed two 24 h dietary recalls at baseline (2008–2011) and provided 6-year follow-up data (2014–2017; n = 7774). We classified 6-year IR status [improved, unchanged (referent), worsened] using a 1-SD change in fasting insulin between visits and defined incident diabetes based on American Diabetes Association criteria. We derived heritage-specific DPs via principal factor analysis and estimated their associations with 6-year IR status (multinomial) and incident diabetes (binary) using complex survey-based logistic regression.

Results

Five overarching DPs based on high-loading foods were shared by two or more heritage groups: “Burger, Fries, & Soft Drinks”; “White Rice, Beans, & Red Meats”; “Fish & Whole Grains”; “Cheese & Sweets”; and “Stew & Corn”. Comparing highest-to-lowest DP quintiles, the Dominican “Burger, Fries, & Soft Drinks” and Cuban “White Rice, Beans, & Red Meats” DPs were associated with worsened 6-year IR status (log-odds: 2.35, 95% CI: 1.02, 3.68, Ptrend = 0.037 and log-odds: 1.27, 95% CI: 0.49, 2.06, Ptrend = 0.009, respectively). The Puerto Rican “Burger, Fries, & Soft Drinks” and the Central American “White Rice, Beans, & Red Meats” DPs were associated with greater diabetes incidence (OR: 3.00, 95% CI:1.50, 5.99 and OR: 2.41, 95% CI: 1.05, 5.50, respectively).

Conclusions

A diet characterized by higher intakes of burgers, fries, and soft drinks and another characterized by higher intakes of white rice, beans, and red meats may be adversely associated with IR and diabetes risk in some Hispanic/Latino heritage groups. Future work is needed to offer more heritage-specific dietary guidance for diabetes prevention in this population.
Only virgin type of olive oil consumption reduces the risk of mortality. Results from a Mediterranean population-based cohort
Authors: Donat-Vargas Carolina , Lopez-Garcia Esther , Banegas José R. , Martínez-González Miguel Á. , Rodríguez-Artalejo Fernando , Guallar-Castillón Pilar
Published: October 2022

Background

Evidence on the association between virgin olive oil (OO) and mortality is limited since no attempt has previously been made to discern about main OO varieties.

Objective

We examined the association between OO consumption (differentiating by common and virgin varieties) and total as well as cause-specific long-term mortality

Methods

12,161 individuals, representative of the Spanish population ≥18 years old, were recruited between 2008 and 2010 and followed up through 2019. Habitual food consumption was collected at baseline with a validated computerized dietary history. The association between tertiles of OO main varieties and all-cause, cardiovascular and cancer mortality were analyzed using Cox models.

Results

After a mean follow-up of 10.7 years (129,272 person-years), 143 cardiovascular deaths, and 146 cancer deaths occurred. The hazard ratio (HR) (95% confidence interval) for all-cause mortality in the highest tertile of common and virgin OO consumption were 0.96 (0.75–1.23; P-trend 0.891) and 0.66 (0.49–0.90; P-trend 0.040). The HR for all-cause mortality per a 10 g/day increase in virgin OO was 0.91 (0.83–1.00). Virgin OO consumption was also inversely associated with cardiovascular mortality, with a HR of 0.43 (0.20–0.91; P-trend 0.017), but common OO was not, with a HR of 0.88 (0.49–1.60; P-trend 0.242). No variety of OO was associated with cancer mortality.

Conclusion

Daily moderate consumption of virgin OO (1 and 1/2 tablespoons) was associated with a one-third lower risk of all-cause as well as half the risk of cardiovascular mortality. These effects were not seen for common OO. These findings may be useful to reappraise dietary guidelines.
Disentangling nigral and putaminal contribution to motor impairment and levodopa response in Parkinson’s disease
Authors: Schröter Nils , Rijntjes Michel , Urbach Horst , Weiller Cornelius , Treppner Martin , Kellner Elias , Jost Wolfgang H. , Sajonz Bastian E. A. , Reisert Marco , Hosp Jonas A. , Rau Alexander
Published: October 2022

The extent to which the degeneration of the substantia nigra (SN) and putamen each contribute to motor impairment in Parkinson’s disease (PD) is unclear, as they are usually investigated using different imaging modalities. To examine the pathophysiological significance of the SN and putamen in both motor impairment and the levodopa response in PD using diffusion microstructure imaging (DMI). In this monocentric retrospective cross-sectional study, DMI parameters from 108 patients with PD and 35 healthy controls (HC) were analyzed using a voxel- and region-based approach. Linear models were applied to investigate the association between individual DMI parameters and Movement Disorder Society Unified Parkinson’s Disease Rating Scale-Part 3 performance in ON- and OFF-states, as well as the levodopa response, controlling for age and sex. Voxel- and region-based group comparisons of DMI parameters between PD and HC revealed significant differences in the SN and putamen. In PD, a poorer MDS-UPDRS-III performance in the ON-state was associated with increased free fluid in the SN (b-weight = 65.79, p = 0.004) and putamen (b-weight = 86.00, p = 0.006), and contrariwise with the demise of cells in both structures. The levodopa response was inversely associated with free fluid both in the SN (b-weight = −83.61, p = 0.009) and putamen (b-weight = −176.56, p < 0.001). Interestingly, when the two structures were assessed together, the integrity of the putamen, but not the SN, served as a predictor for the levodopa response (b-weight = −158.03, p < 0.001). Structural alterations in the SN and putamen can be measured by diffusion microstructure imaging in PD. They are associated with poorer motor performance in the ON-state, as well as a reduced response to levodopa. While both nigral and putaminal integrity are required for good performance in the ON-state, it is putaminal integrity alone that determines the levodopa response. Therefore, the structural integrity of the putamen is crucial for the improvement of motor symptoms to dopaminergic medication, and might therefore serve as a promising biomarker for motor staging.
Early dynamics of chronic myeloid leukemia on nilotinib predicts deep molecular response
Authors: Okamoto Yuji , Hirano Mitsuhito , Morino Kai , Kajita Masashi K. , Nakaoka Shinji , Tsuda Mayuko , Sugimoto Kei-ji , Tamaki Shigehisa , Hisatake Junichi , Yokoyama Hisayuki , Igarashi Tadahiko , Shinagawa Atsushi , Sugawara Takeaki , Hara Satoru , Fujikawa Kazuhisa , Shimizu Seiichi , Yujiri Toshiaki , Wakita Hisashi , Nishiwaki Kaichi , Tojo Arinobu , Aihara Kazuyuki
Published: October 2022

Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by the BCR-ABL1 tyrosine kinase. Although ABL1-specific tyrosine kinase inhibitors (TKIs) including nilotinib have dramatically improved the prognosis of patients with CML, the TKI efficacy depends on the individual patient. In this work, we found that the patients with different nilotinib responses can be classified by using the estimated parameters of our simple dynamical model with two common laboratory findings. Furthermore, our proposed method identified patients who failed to achieve a treatment goal with high fidelity according to the data collected only at three initial time points during nilotinib therapy. Since our model relies on the general properties of TKI response, our framework would be applicable to CML patients who receive frontline nilotinib or other TKIs.
Optical mapping compendium of structural variants across global cattle breeds
Authors: Talenti A. , Powell J. , Wragg D. , Chepkwony M. , Fisch A. , Ferreira B. R. , Mercadante M. E. Z. , Santos I. M. , Ezeasor C. K. , Obishakin E. T. , Muhanguzi D. , Amanyire W. , Silwamba I. , Muma J. B. , Mainda G. , Kelly R. F. , Toye P. , Connelley T. , Prendergast J.
Published: October 2022

Structural variants (SV) have been linked to important bovine disease phenotypes, but due to the difficulty of their accurate detection with standard sequencing approaches, their role in shaping important traits across cattle breeds is largely unexplored. Optical mapping is an alternative approach for mapping SVs that has been shown to have higher sensitivity than DNA sequencing approaches. The aim of this project was to use optical mapping to develop a high-quality database of structural variation across cattle breeds from different geographical regions, to enable further study of SVs in cattle. To do this we generated 100X Bionano optical mapping data for 18 cattle of nine different ancestries, three continents and both cattle sub-species. In total we identified 13,457 SVs, of which 1,200 putatively overlap coding regions. This resource provides a high-quality set of optical mapping-based SV calls that can be used across studies, from validating DNA sequencing-based SV calls to prioritising candidate functional variants in genetic association studies and expanding our understanding of the role of SVs in cattle evolution.
A detailed behavioral, videographic, and neural dataset on object recognition in mice
Authors: Rodgers Chris C.
Published: October 2022

Mice adeptly use their whiskers to touch, recognize, and learn about objects in their environment. This behavior is enabled by computations performed by populations of neurons in the somatosensory cortex. To understand these computations, we trained mice to use their whiskers to recognize different shapes while we recorded activity in the barrel cortex, which processes whisker input. Here, we present a large dataset of high-speed video of the whiskers, along with rigorous tracking of the entire extent of multiple whiskers and every contact they made on the shape. We used spike sorting to identify individual neurons, which responded with precise timing to whisker contacts and motion. These data will be useful for understanding the behavioral strategies mice use to explore objects, as well as the neuronal dynamics that mediate those strategies. In addition, our carefully curated labeled data could be used to develop new computer vision algorithms for tracking body posture, or for extracting responses of individual neurons from large-scale neural recordings.
A CBCT based cross sectional study on the prevalence and anatomical feature of C shaped molar among Jordanian
Authors: Al Omari Taher , AlKhader Mustafa , Ateş Ayfer Atav , Wahjuningrum Dian Agustin , Dkmak Alaa , Khaled Waheeb , Alzenate Hazem
Published: October 2022

The prevalence and anatomical features of C-Shaped Mandibular Second Molars (MSMs) are rarely studied in Jordanian sub-population. This study then took a part to evaluate the prevalence of C-shaped in MSMs using cone-beam computed tomography (CBCT) in the Jordanian sub-population. It used a cross-sectional design and three thousand scans collected over eight years between 2011 and 2019. The data were then reviewed for whether they were fully formed of MSMs. A total of 2037 cases that had 2845 MSMs were evaluated to identify C-shaped canals at coronal, middle, and apical sites. An oblique slicing module perpendicular to the long axis of MSMs was used to evaluate the teeth. The type and frequency of C-shaped canals, as well as the correlations between sex and side (right/left) and between sex and groove direction (buccal/lingual) were measured using the chi-square test on SPSS software at the significance level of 95%. A total of 342 teeth of 243 patients were C-shaped molars, which comprised 12% of the patient’s teeth and 99 of them as a bilateral C-shaped canal with mean age of 40 years and sex ratio of 2:1 between female and male. With the limitations of this study, the lingual groove and type 3 were the most common properties of MSM. Besides, the Jordanian population mostly had C-shaped canals.
Integrated network-based multiple computational analyses for identification of co-expressed candidate genes associated with neurological manifestations of COVID-19
Authors: Hazra Suvojit , Chaudhuri Alok Ghosh , Tiwary Basant K. , Chakrabarti Nilkanta
Published: October 2022

‘Tripartite network’ (TN) and ‘combined gene network’ (CGN) were constructed and their hub-bottleneck and driver nodes (44 genes) were evaluated as ‘target genes’ (TG) to identify 21 ‘candidate genes’ (CG) and their relationship with neurological manifestations of COVID-19. TN was developed using neurological symptoms of COVID-19 found in literature. Under query genes (TG of TN), co-expressed genes were identified using pair-wise mutual information to genes available in RNA-Seq autopsy data of frontal cortex of COVID-19 victims. CGN was constructed with genes selected from TN and co-expressed in COVID-19. TG and their connecting genes of respective networks underwent functional analyses through findings of their enrichment terms and pair-wise ‘semantic similarity scores’ (SSS). A new integrated ‘weighted harmonic mean score’ was formulated assimilating values of SSS and STRING-based ‘combined score’ of the selected TG-pairs, which provided CG-pairs with properties of CGs as co-expressed and ‘indispensable nodes’ in CGN. Finally, six pairs sharing seven ‘prevalent CGs’ (ADAM10, ADAM17, AKT1, CTNNB1, ESR1, PIK3CA, FGFR1) showed linkages with the phenotypes (a) directly under neurodegeneration, neurodevelopmental diseases, tumour/cancer and cellular signalling, and (b) indirectly through other CGs under behavioural/cognitive and motor dysfunctions. The pathophysiology of ‘prevalent CGs’ has been discussed to interpret neurological phenotypes of COVID-19.
Teleportation of hybrid entangled states with continuous-variable entanglement
Authors: He Mingjian , Malaney Robert
Published: October 2022

Hybrid entanglement between discrete-variable (DV) and continuous-variable (CV) quantum systems is an essential resource for heterogeneous quantum networks. Our previous work showed that in lossy channels the teleportation of DV qubits, via CV-entangled states, can be significantly improved by a new protocol defined by a modified Bell state measurement at the sender. This work explores whether a new, similarly modified, CV-based teleportation protocol can lead to improvement in the transfer of hybrid entangled states. To set the scene, we first determine the performance of such a modified protocol in teleporting CV-only qubits, showing that significant improvement over traditional CV-based teleportation is obtained. We then explore similar modifications in the teleportation of a specific hybrid entangled state showing that significant improvement over traditional CV-based teleportation is again found. For a given channel loss, we find teleporting the DV qubit of the hybrid entangled state can always achieve higher fidelity than teleporting the CV qubit. We then explore the use of various non-Gaussian operations in our modified teleportation protocol, finding that, at a cost of lower success probability, quantum scissors provides the most improvement in the loss tolerance. Our new results emphasize that in lossy conditions, the quantum measurements undertaken at the sender can have a surprising and dramatic impact on CV-based teleportation.
Optical tomography dynamics induced by qubit-resonator interaction under intrinsic decoherence
Authors: Mohamed A. -B. A. , Eleuch H.
Published: October 2022

A superconducting circuit with a qubit and a resonator coupled via a two-photon interaction is considered. When the resonator is initially in a superposition of coherent states, optical tomography and quantum coherence dynamics are examined in the context of intrinsic decoherence. The results reveal that optical tomography is a good quantifier of the quantum coherence produced by the qubit-resonator interaction. The effects of qubit-resonator detuning and intrinsic decoherence on the dynamics of optical tomography distributions for coherent and even coherent states are investigated. The dynamics of optical tomography distributions are highly dependent on detuning and intrinsic decoherence. Our numerical simulations reveal that there is a relation between the optical tomography and the generated quantum coherence. When the qubit-resonator detuning and intrinsic decoherence are augmented, the amplitude and intensity, as well as the structure of the optical tomography, change substantially.
Anthropogenic microparticles in the emerald rockcod Trematomus bernacchii (Nototheniidae) from the Antarctic
Authors: Bottari Teresa , Nibali Valeria Conti , Branca Caterina , Grotti Marco , Savoca Serena , Romeo Teresa , Spanò Nunziacarla , Azzaro Maurizio , Greco Silvestro , D’Angelo Giovanna , Mancuso Monique
Published: October 2022

Anthropogenic microparticles (AMs) were found for the first time in specimens of Trematomus bernacchii collected in 1998 in the Ross Sea (Antarctica) and stored in the Antarctic Environmental Specimen Bank. Most of the identified AMs were fibers of natural and synthetic origin. The natural AMs were cellulosic, the synthetic ones were polyester, polypropylene, polypropylene/polyester, and cellulose acetate. The presence of dyes in the natural AMs indicates their anthropogenic origin. Five industrial dyes were identified by Raman spectroscopy with Indigo occurring in most of them (55%). Our research not only adds further data to the ongoing knowledge of pollution levels in the Antarctic ecosystem, it provides an interesting snapshot of the past, highlighting that microplastics and anthropogenic fiber pollution had already entered the Antarctic marine food web at the end of the ‘90 s. These findings therefore establish the foundations for understand the changes in marine litter pollution over time.
Naïve pluripotent-like characteristics of non-tumorigenic Muse cells isolated from human amniotic membrane
Authors: Ogawa Eiji , Oguma Yo , Kushida Yoshihiro , Wakao Shohei , Okawa Kana , Dezawa Mari
Published: October 2022

Multilineage-differentiating stress-enduring (Muse) cells are non-tumorigenic pluripotent-like stem cells that exhibit triploblastic differentiation and self-renewability at the single-cell level, and are collectable as pluripotent surface marker SSEA-3(+) from the bone marrow (BM), peripheral blood, and organ connective tissues. SSEA-3(+) cells from human amniotic membrane mesenchymal stem cells (hAMSCs) were compared with hBM-Muse cells. Similar to hBM-Muse cells, hAMSC-SSEA-3(+) cells expressed pluripotency genes (OCT3/4, NANOG, and SOX2), differentiated into triploblastic cells from a single cell, self-renewed, and exhibited non-tumorigenicity. Notably, however, they exhibited unique characteristics not seen in hBM-Muse cells, including higher expression of genes related to germline- and extraembryonic cell-lineages compared with those in hBM-Muse cells in single-cell RNA-sequencing; and enhanced expression of markers relevant to germline- (PRDM14, TFAP2C, and NANOS3) and extraembryonic cell- (CDX2, GCM1, and ID2) lineages when induced by cytokine subsets, suggesting a broader differentiation potential similar to naïve pluripotent stem cells. t-SNE dimensionality reduction and Gene ontology analysis visualized hAMSC-SSEA-3(+) cells comprised a large undifferentiated subpopulation between epithelial- and mesenchymal-cell states and a small mesenchymal subpopulation expressing genes relevant to the placental formation. The AM is easily accessible by noninvasive approaches. These unique cells are a potentially interesting target naïve pluripotent stem cell-like resource without tumorigenicity.
Lipid-mediated delivery of CD47 siRNA aids JQ1 in ensuring simultaneous downregulation of PD-L1 and CD47 and improves antitumor immunotherapy efficacy
Authors: Li Yong , Meng Xianying , Chen Guang , Hou Yue , Wu Xuan , Wang Jialiang , Cong Xiuxiu , Mao Kuirong , Wu Chenxi , Chen Hongmei , Sun Xu , Zhou Jingjing , Wang Ye , Yang Yong-Guang , Sun Tianmeng
Published: October 2022

Cancer immunotherapy using immune checkpoint blockade has become an attractive treatment option for patients with different cancers.
4′-Alkylseleno-4-cyanobiphenyls, nSeCB: synthesis and substituent effects on the phase-transition and liquid crystalline behaviors
Authors: Arakawa Yuki , Shiba Takuma , Igawa Kazunobu , Sasaki Shunsuke , Tsuji Hideto
Published: October 2022

A homologous series of 4′-alkylseleno-4-cyanobiphenyls (nSeCB) was synthesized and their phase-transition behaviors were investigated and compared with those of the alkyl, alkoxy, and alkylthio homologs.
Insights into the effect of oxygen vacancies on the epoxidation of 1-hexene with hydrogen peroxide over WO3−x/SBA-15
Authors: Li Penghui , Gao Junhua , Shi Jing , Wang Huixiang , Xing Xiangying , Ren Jingzhao , Meng Yu , Wang Liancheng , Lv Baoliang
Published: October 2022

The introduction of oxygen vacancies improved 1-hexene epoxidation performance over WO3−x/SBA-15 catalysts, which is attributed to the enhanced Lewis acidity of the active centers and the reduced energy barrier of the rate-determining step.
Effects of strong coordination bonds at the axial or equatorial positions on magnetic relaxation for pentagonal bipyramidal dysprosium(iii) single-ion magnets
Authors: Li Min , Han Jiayi , Wu Haipeng , Du Yi-en , Liu Yufang , Chen Yongqiang , Chen Sanping
Published: October 2022

Pentagonal bipyramidal dysprosium(iii) complexes with different strong coordination bonds at axial or equatorial positions show a significant variation in their magnetic relaxation behavior.
Aqueous conversion of monosaccharides to furans: were we wrong all along to use catalysts?
Authors: Jakob Ana , Likozar Blaž , Grilc Miha
Published: October 2022

Dehydration of the most relevant biomass derived monosaccharides, xylose, glucose and fructose, was investigated to attain value-added platform chemicals: furfural, hydroxymethylfurfural (5-HMF) and levulinic acid (LA).
Short and efficient synthesis of alkylresorcinols: a route for the preparation of cannabinoids
Authors: Villano Rosaria , Straker Hannah , Di Marzo Vincenzo
Published: October 2022

In this work, we describe a general and efficient method for the preparation of alkylresorcinols (ARs), also in deuterated form.
Correction: Eliciting an immune hot tumor niche with biomimetic drug-based multi-functional nanohybrids augments immune checkpoint blockade-based breast cancer therapy
Authors: Du Wei , Chen Chen , Sun Peng , Zhang Shengchang , Zhang Jing , Zhang Xiaoyu , Liu Ying , Zhang Rui , Yan Chongzheng , Fan Changchun , Wu Jibiao , Jiang Xinyi
Published: October 2022

Correction for ‘Eliciting an immune hot tumor niche with biomimetic drug-based multi-functional nanohybrids augments immune checkpoint blockade-based breast cancer therapy’ by Wei Du et al., Nanoscale, 2020, 12, 3317–3329, https://doi.org/10.1039/C9NR09835F.
Transition metal-free reductive coupling of allylic sulfonylhydrazones with aryl boronic acids for C(sp3)–C(sp2) bond formation
Authors: Ali Kasim , Prajapati Gurudayal , Ampapathi Ravi Sankar , Panda Gautam
Published: October 2022

The reductive coupling between allylic sulfonylhydrazones and aryl boronic acids gives 1,3-diarylpropene systems with good to excellent yields under very simple reaction conditions without metal catalysts and an inert atmosphere.
Efficient synthesis of benzosultams containing continuous quaternary carbons via trapping active ylides with cyclic N-sulfonyl ketimines
Authors: Luo Zhengli , Chen Xuwen , Xue Jian , Deng Yaqi , Dong Suzhen , Liu Shunying
Published: October 2022

A rapid and efficient method for the synthesis of benzosultams containing continuous quaternary carbons in a one pot fashion has been developed with moderate to excellent yields at room temperature under air. The resulting products exhibit good anticancer activity in osteosarcoma cells.
Graphene oxide reinforced silk fibroin nanocomposite as an electroactive interface for the estimation of dopamine
Authors: Noor Afifa , Khalid Hamad , Aslam Muhammad , Hayat Akhtar , Khan Ather Farooq , Nasir Muhammad , Chaudhry Aqif Anwar , Nawaz Mian Hasnain
Published: October 2022

Schematic representation of fabrication of a GO-SF based flexible CC interface for DA estimation.
Advanced preparation and application of transition metal selenides in lithium–sulfur batteries: a review
Authors: Wang Hao , Deng Nanping , Wang Shuaishuai , Wang Xiaoxiao , Li Yanan , Zeng Qiang , Luo Shengbin , Cui Xianfeng , Cheng Bowen , Kang Weimin
Published: October 2022

In this review, we systematically summarize the working mechanism in the cycle process of the batteries, the preparation ways, the research progress and future developments of transition metal selenides in Li–S cells.
Facile synthesis of nitroamino-1,3,4-oxadiazole with azo linkage: a new family of high-performance and biosafe energetic materials
Authors: Banik Shreyasi , Kumar Pradeep , Ghule Vikas D. , Khanna Shweta , Allimuthu Dharmaraja , Dharavath Srinivas
Published: October 2022

Energetic materials serve as remarkable fuel/propellants for space shuttles, and their utility in civil and military applications is vast.
Efficient and hysteresis-free mixed-dimensional 2D/3D perovskite solar cells using ethyl lactate as a green additive to perovskite precursor solutions
Authors: Majeed Sadeer M. , Mohammed Mustafa K. A. , Ahmed Duha S.
Published: October 2022

Ethyl lactate is utilized for the first time as a green solvent to enhance the quality of anti-solvent-assisted solution-engineered perovskite films.
Ultra-dense interferometric chain architecture for datacom and telecom applications
Authors: Bidnyk Serge , Yadav Ksenia , Balakrishnan Ashok
Published: October 2022

Further increase in the density of integrated planar lightwave circuits (PLCs) depends on the introduction of compact guided-wave layout solutions. We describe a novel architecture for coiling multistage interferometric devices with densities reaching the theoretical limit. Our approach is validated by the design, fabrication, and deployment of state-of-the-art PLCs based on the proposed architecture for use in datacom and telecom applications.
Polarization dependency of the 3D transfer behavior in microsphere enhanced interferometry
Authors: Hüser Lucie , Pahl Tobias , Lehmann Peter
Published: October 2022

Enhancing the lateral resolution limit in optical microscopy and interferometry is of great interest in recent research. In order to laterally resolve structures including feature dimensions below the resolution limit, microspheres applied in the optical near-field of the specimen are shown to locally improve the resolution of the imaging system. Experimental and simulated results following this approach obtained by a high NA Linnik interferometer are analyzed in this contribution. For further understanding of the transfer characteristics, measured interference data are compared with FEM (finite element method) based simulations with respect to the polarization dependency of the relevant image information.
Quasi-analytical and rigorous modeling of interference microscopy
Authors: Pahl Tobias , Breidenbach Johannes , Lehmann Peter
Published: October 2022

We present an extended vectorial Kirchhoff model of coherence scanning interferometry including several vector rotations occurring in the imagining and scattering process as well as polarization dependent reflection coefficients. For validation simulated results are compared to those of the conventional scalar Kirchhoff model and a rigorous finite element modeling.
Analysis of size and concentration of microplastics in water using static light scattering combined with PCA and LDA
Authors: Choobbari Mehrdad Lotfi , Ciaccheri Leonardo , Chalyan Tatevik , Adinolfi Barbara , Meulebroeck Wendy , Ottevaere Heidi
Published: October 2022

Quantitative analysis of size and concentration of microplastics is a crucial step for having a better understanding of plastic pollution in the environment. Such information is typically obtained in a single particle mode that significantly increases the analysis time and can be a cumbersome task. Therefore, we demonstrate here a measurement technique based on Static Light Scattering (SLS) combined with chemometric methods such as Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) for resolving the size and concentration of multiple microplastic particles in water. Two sets of samples with uniform and non-uniform size distribution of microplastics, called “monodisperse” and “polydisperse”, respectively, are fully investigated. It is shown that a relationship exists between the scattering signals of mono- and polydisperse samples on the PCA space. Hence, a PCA-LDA model that is constructed on the PCA space of monodisperse samples is used to discriminate the size of the microplastics in polydisperse samples. By specifying the size of the particles, their concentration is determined using a simple linear fit.
Micro-reactors fabricated by Subaquatic indirect Laser-Induced Plasma-Assisted Ablation on soda-lime glass substrates
Authors: Flores-Arias M. Teresa , Gómez-Varela Ana I. , Munuzuri Alberto P. , Carballosa Alejandro , Bao-Varela Carmen
Published: October 2022

Synchronization control of complex systems is a field that emerged with huge interest and aims to study new possible routes to synchronization in networks of non-locally coupled chemical oscillators. Light can be used to stimulate these systems and to be able to synchronize the different micro-reactors involved in the complex system. To this end, transparent reactors with good optical qualities are needed. Glass is the most appropriated material to be used for fabricating the micro-reactors. Subaquatic indirect Laser-Induced Plasma-Assisted Ablation is presented as a laser technique that combines underwater ablation with shock waves as a potential technique for fabricating these micro-reactors by using a Nd:YVO4 laser.
Construction of Intelligent Business English Teaching Platform Based on Modern Information Technology
Authors: Xie Li
Published: October 2022

With the development of information technology, it is of great practical significance to construct an intelligent teaching platform for business English to supplement the traditional business English teaching. Through the analysis of the current situation of Business English teaching, we can see that the emphasis on theory teaching has neglected the cultivation of students' Business English practical skills. Facing the new business English application environment, by highlighting the characteristics of professionalism and innovation, giving full play to the advantages of information technology application, and building an intelligent teaching platform for business English, promoting business English teaching in an all-round way and realizing real reform.
Numerical Simulations in SCR systems with Emphasis on Uniform Flow at the Catalyst Inlet
Authors: Novák Martin , Matas Richard
Published: October 2022

Selective Catalytic Reduction (SCR) is one of the most widely used technologies for reducing emissions from diesel engines, which are widely used in the energy world. This technology is very complex, and it is not currently possible to address all aspects of it comprehensively. This study focuses on trying to improve the distribution of the exhaust stream at the catalyst inlet using models which represent the most common geometric distributions. Four types of geometries are selected, complemented by a fifth design, which is used as a reference, to find the maximum achievable values of the parameters under study. In this case, mainly the uniformity index is addressed, which indicates how uniformly the selected variable is distributed over the particular area. The study presents possible modifications of the flue gas duct which will be generally applied.
A comparison of natural and induced diversity in plant oils
Authors: Chardot Thierry
Published: October 2022

Currently, there is a growing demand to replace the compounds in a given product that are of a petroleum origin with renewable resources. One of these compounds, called fatty acid (FA), is the main component of vegetable oils. FA composition is not only responsible for the physicochemical properties of plant oils, but it also determines their uses. For example, since time immemorial, products containing lipids have been used for lighting and heating purposes. They are also excellent lubricants and possess drying properties important molecules for painting, and wood preservation. In terms of nutrition, they have a high-energy content, are part of our daily health requirements, and are used for animal feed. We present here some lipids of interest, the plants that produce them naturally with high yield, the enzymes responsible for their synthesis when known, and their possible uses, as well as resources and ways that could allow the lipids of interest to be produced in quantity in different hosts.
Vieillissement de la population et dépendance : Un coût social autant que médical
Authors: Davin Bérengère , Paraponaris Alain
Published: October 2022

Le vieillissement de la population est communément présenté comme un facteur majeur de
l’augmentation des dépenses de santé. La concomitance des deux phénomènes ne vaut toutefois
pas causalité. En effet, les habitudes de consommation de soins de plus en plus coûteux et la
médicalisation croissante de la santé chez toutes les générations, y compris les plus âgées,
semblent avoir un impact plus important dans la hausse des dépenses de soins et de biens
médicaux. Pour autant, aux côtés des frais médicaux, l’avancée dans l’âge révèle des besoins
croissants en aide humaine destinée à compenser la perte d’autonomie, éventuellement complétée
par des dispositifs techniques. Cette aide humaine est en grande partie assumée par l’entourage
proche, sur lequel elle fait peser des coûts dont l’évaluation économique dépasse largement ceux
tirés des comptes officiels de la dépendance.
Les immigrés face au VIH
Authors: Desgrées du Loû Annabel
Published: October 2022

Les immigrés, en particulier ceux venus d’Afrique subsaharienne, représentent une part importante des
personnes vivant avec le VIH en France. Cela est dû en partie au contexte épidémiologique des pays
d’origine, l’Afrique subsaharienne étant le continent le plus touché au monde par l’épidémie. Mais une
partie des contaminations surviennent aussi en France, après la migration, ce qui signe une
vulnérabilité spécifique dans ce groupe par rapport au risque d’infection VIH. Chez les immigrés, des
diagnostics VIH parfois tardifs, des situations de précarité peuvent minorer le succès des traitements.
Prévenir et prendre en charge le VIH/Sida le plus tôt possible chez les personnes étrangères qui arrivent
en France est donc un impératif de santé publique, qui implique de mieux comprendre les difficultés
sociales, administratives, économiques qu’elles peuvent rencontrer et qui augmentent les difficultés
d’accès au dépistage et les prises de risque, difficultés qui compliquent la vie avec la maladie.
Recherche interventionnelle en santé publique, transfert de connaissances et collaboration entre acteurs, décideurs et chercheurs : Le défi français de l’innovation
Authors: Cambon Linda , Alla François
Published: October 2022

L’utilisation des connaissances scientifiques dans la décision est un enjeu majeur pour notre système
de santé. Les obstacles à cette démarche sont liés à la production de la preuve, complexe dans ce
domaine, et à la difficulté de son intégration dans les processus décisionnels et les pratiques
professionnelles. Ces obstacles tiennent aux personnes, aux organisations, au contexte et à la nature
des preuves elles-mêmes. La démarche probante demande par conséquent à situer la réflexion à un
niveau systémique où se situe le transfert de connaissances, processus continu d’échanges entre
chercheurs et acteurs, favorisant la diffusion, l’adoption et l’appropriation des connaissances en vue
de leur utilisation dans la pratique et la décision. Lever ces obstacles revient à renforcer les équipes
de recherche interventionnelle, à transformer les processus d’élaboration des politiques publiques et,
plus encore, à créer des ponts entre recherche, action et décision dans une démarche intégrative de
recherche translationnelle de santé publique.
Spécificité des requêtes d’information dans une collaboration BIM
Authors: Rahhal Anabelle , Ben Rajeb Samia , Leclercq Pierre
Published: October 2022

Dans l’écosystème numérique de la construction, comprenant les croisement disciplinaires et technologiques du Building Information Management (BIM), cet article propose une analyse des requêtes d’information effectuées, afin de mener à bien trois missions d’évaluation d’un projet: l’estimation du coût de la construction, la planification 5D du chantier et l’estimation du coût du fonctionnement du bâtiment. Notre recherche s’appuie sur un cadre expérimental d’un projet collaboratif, mené en BIM, trois années consécutives de 2019 à 2021. Les résultats de l’enquête menée sont exposés et ils permettent de spécifier les requêtes d’information, dans le cadre de collaborations BIM, là où la gestion de l’information est au coeur des problématiques actuelles.
Laser-material interactions improve biomedical device applications
Authors: Thompson Avery
Published: October 2022

Laser etching, patterning, and coating can alter the interactions between materials and the human body, increasing performance or creating unique effects.
An empirical study on network conversion of stock time series based on STL method
Authors: Tian Feng , Wang Dan , Wu Qin , Wei Daijun
Published: October 2022

A complex network has been widely used to reveal the rule of a complex system. How to convert the stock data into a network is an open issue since the stock data are so large and their random volatility is strong. In this paper, a seasonal trend decomposition procedure based on the loess (STL) method is applied to convert the stock time series into a directed and weighted symbolic network. Three empirical stock datasets, including the closing price of Shanghai Securities Composite Index, S&P 500 Index, and Nikkei 225 Index, are considered. The properties of these stock time series are revealed from the topological characteristics of corresponding symbolic networks. The results show that: (1) both the weighted indegree and outdegree distributions obey the power-law distribution well; (2) fluctuations of stock closing price are revealed by related network topological properties, such as weighting degree, betweenness, pageranks, and clustering coefficient; and (3) stock closing price, in particular, periods such as financial crises, can be identified by modularity class of the symbolic networks. Moreover, the comparison between the STL method and the visibility graph further highlights the advantages of the STL method in terms of the time complexity of the algorithm. Our method offers a new idea to study the network conversion of stock time series.
Collective excitability in highly diluted random networks of oscillators
Authors: Paolini Gabriele , Ciszak Marzena , Marino Francesco , Olmi Simona , Torcini Alessandro
Published: October 2022

We report on collective excitable events in a highly diluted random network of non-excitable nodes. Excitability arises thanks to a self-sustained local adaptation mechanism that drives the system on a slow timescale across a hysteretic phase transition involving states with different degrees of synchronization. These phenomena have been investigated for the Kuramoto model with bimodal distribution of the natural frequencies and for the Kuramoto model with inertia and a unimodal frequency distribution. We consider global and partial stimulation protocols and characterize the system response for different levels of dilution. We compare the results with those obtained in the fully coupled case showing that such collective phenomena are remarkably robust against network diluteness.
Current-induced perpendicular effective magnetic field in magnetic heterostructures
Authors: Liu Qianbiao , Zhu Lijun
Published: October 2022

The generation of perpendicular effective magnetic field or perpendicular spins (σz) is central for the development of energy-efficient, scalable, and external-magnetic-field-free spintronic memory and computing technologies. Here, we report the first identification and the profound impacts of a significant effective perpendicular magnetic field that can arise from asymmetric current spreading within magnetic microstrips and Hall bars. This effective perpendicular magnetic field can exhibit all the three characteristics that have been widely assumed in the literature to “signify” the presence of a flow of σz, i.e., external-magnetic-field-free current switching of uniform perpendicular magnetization, a sin 2φ-dependent contribution in spin-torque ferromagnetic resonance signal of in-plane magnetization (φ is the angle of the external magnetic field with respect to the current), and a φ-independent but field-dependent contribution in the second harmonic Hall voltage of in-plane magnetization. This finding suggests that it is critical to include current spreading effects in the analyses of various spin polarizations and spin–orbit torques in the magnetic heterostructure. Technologically, our results provide a perpendicular effective magnetic field induced by asymmetric current spreading as a novel, universally accessible mechanism for efficient, scalable, and external-magnetic-field-free magnetization switching in memory and computing technologies.
Ultrafast 2DIR comparison of rotational energy transfer, isolated binary collision breakdown, and near critical fluctuations in Xe and SF6 solutions
Authors: Rotondaro Matthew C. , Jain Arkash , Erramilli Shyamsunder , Ziegler Lawrence D.
Published: October 2022

The density dependence of rotational and vibrational energy relaxation (RER and VER) of the N2O ν3 asymmetric stretch in dense gas and supercritical Xe and SF6 solutions for near critical isotherms is measured by ultrafast 2DIR and infrared pump–probe spectroscopy. 2DIR analysis provides precise measurements of RER at all gas and supercritical solvent densities. An isolated binary collision (IBC) model is sufficient to describe RER for solvent densities ≤ ∼4M where rotational equilibrium is re-established in ∼1.5–2.5 collisions. N2O RER is ∼30% more efficient in SF6 than in Xe due to additional relaxation pathways in SF6 and electronic factor differences. 2DIR analysis revealed that N2O RER exhibits a critical slowing effect in SF6 at near critical density (ρ* ∼ 0.8) where the IBC model breaks down. This is attributable to the coupling of critical long-range density fluctuations to the local N2O free rotor environment. No such RER critical slowing is observed in Xe because IBC break down occurs much further from the Xe critical point. Many body interactions effectively shield N2O from these near critical Xe density fluctuations. The N2O ν3 VER density dependence in SF6 is different than that seen for RER, indicating a different coupling to the near critical environment than RER. N2O ν3 VER is only about ∼7 times slower than RER in SF6. In contrast, almost no VER decay is observed in Xe over 200 ps. This VER solvent difference is due to a vibrationally resonant energy transfer pathway in SF6 that is not possible for Xe.