bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Kapasitas Manajemen Kewirausahaan Dalam Bumdesa “Bina Sejahtera” Desa Dadapkuning, Kecamatan Cerme, Kabupaten Gresik
Authors: Diajeng Putri Yanuardani  , Lukman Arif
Published: July 2022

Penelitian ini bertujuan untuk mengetahui kapasitas manajemen kewirausahaan Bumdesa “Bina Sejahtera” Desa Dadapkuning, Kecamatan Cerme, Kabupaten Gresik. Teori yang digunakan dalam penelitian ini dari (Muhammad, 2007) yang menuliskan dalam disertasinya bahwa kapsitas manjemen kewirausahaan digambarkan melalui dua unsur yakni kapasitas manajer dan sistem manajemen. Desain penilitian menggunakan metode deskriptif dengan pendekatan kualitatif. Data didapatkan dengan melakukan kegiatan observasi lapangan, wawancara serta dokumentasi.  Hasil penelitian menunjukan bahwa aspek kapasitas manajer dianggap cukup baik meliputi aspek profesionalitas, sistem kompetisi, penilaian dan perbaikan kinerja, desentralisasi kewenangan, partisipasi dan transparansi. Sedangkan dalam sistem manajemen kapasitas yang dimiliki cukup baik dalam prosedur pelayanan, perilaku petugas dan kepastian biaya, meskipun juga belum optimal dalam struktur hirarki pelayanan dibuktikan melalui belum adanya ketentuan struktur hirarki pelayanan secara tertulis meskipun dalam menjangkau pelayanan BUM Desa Bina Sejahtera dinilai cukup mudah.
Pengaruh User Generated Content Dan E-Wom Pada Aplikasi Tik-Tok Terhadap Purchase Intention Produk Fashion
Authors: Dila Khoirin anisa  , Novi Marlena
Published: July 2022

Penelitian ini dilakukan dengan bertujuan untuk mengetahui bagaimana pengaruh user generated content (UGC) dan electronic word of mouth pada aplikasi TikTok terhadap purchase intention produk fashion. Jenis penelitian ini ialah penelitian kuantitatif. Populasi dari penelitian ini yaitu pengguna aplikasi TikTok dengan minimal berusia 17 tahun, dalam menentukan pengambilan sampel menggunakan purposive sampling dengan jumlah 100 sampel yang akan diambil. Teknik pengumpulan data penelitian ini menggunakan instrument penelitian berupa  kuisoner yang didistribusikan melalui Google Form, yang kemudian diolah menggunakan program SPSS untuk menganalisis uji regresi. Hasil yang diperoleh yaitu user generated content (UGC) pada memiliki pengaruh positif yang signifikan pada purchase intention, E-Wom memiliki pengaruh positif yang signifikan pada purchase intention.
Pengaruh Nilai Pelanggan dan Kualitas Pelayanan Terhadap Kepuasan Pelanggan Pada Jasa Makeup
Authors: Sarifuddin. T  , Cahyaning Raheni  , Setiawan Mandala Putra  , Ni Nyoman Lilik
Published: July 2022

Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis pengaruh dari nilai pelanggan dan kualitas layanan terhadap kepuasan pelanggan. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian asosiatif. Lokasi penelitian ini dilakukan di Jasa Make Up Mahataksu Wedding yang beralamatkan di jalan Merpati Kota Palu. Jenis dan sumber data yang digunakan dalam penelitian ini yaitu, data primer dan data sekunder. Populasi dalam penelitian ini adalah seluruh pelanggan yang pernah menggunakan jasa Make Up Mahataksu Wedding sejak berdirinya dari tahun 2020-2022. Sampel dalam penelitian ini adalah seluruh pelanggan yang pernah menggunakan jasa Make Up Mahataksu Wedding sejak periode penelitian khususnya pelanggan untuk prosesi pernikahan (Wedding) berjumlah 40 orang. Alat analisis yang digunakan pada penelitian ini yaitu analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa nilai pelanggan dan kualitas layanan secara simultan berpengaruh signifikan terhadap kepuasan konsumen. Selanjtunya, nilai pelanggan juga ditemukan secara parsial berpengaruh positif dan signifikan terhadap kepuasan konsumen, artinya semakin baik nilai yang didapatkan oleh pelanggan maka akan meningkat pula kepuasan dari konsumen tersebut. Selain itu, penelitian ini juga menemukan bahwa kualitas layanan secara parsial berpengaruh positif dan signifikan terhadap kepuasan konsumen, hal ini mengartikan bahwa semakin baik dan berkualitas bentuk layanan yang diberikan maka semakin meningkat pula kepuasan dari konsumen tersebut.
SISTEM PEMBARUAN OTOMATIS PERANGKAT LUNAK PADA SISTEM KENDALI PESAWAT TERBANG, STUDI KASUS: MCAS BOEING 737 MAX
Authors: Fandy Muhammad Alfandy Pramana Lubis , Yudhono Reo , Luqman Bukhori Muhammad
Published: July 2022

Maneuvering characteristic augumentation system adalah sistem komputer yang digunakan untuk mencegah terjadinya nose up berlebih pada pesawat Boeing 737 Max, semakin tinggi nose up dari pesawat akan menyebabkan pesawat kehilangan gaya angkat (stall). Sistem ini dibuat untuk mengkompensasi adanya pergeseran engine baru pada pesawat Boeing 737 Max yang cenderung kedepan, namun hal ini tidak diimbangi dengan perhitungan center of gravity yang baru. Sehingga pesawat memiliki kecenderungan untuk selalu nose up, sehingga dengan adanya sistem MCAS dapat menghindari pesawat cenderung nose up. Namun akibat sistem MCAS yang salah pembacaan terhadap posisi aktual pesawat maka MCAS akan mengendalikan elevator agar pesawat dapat nose down, karena pilot belum bisa mematikan MCAS maka pilot kesulitan untuk mengendalikan pesawat dan pesawat mengalami kecelakaan. Berdasarkan permasalahan tersebut peneliti membuat sebuah rancangan software pengganti MCAS yang memiliki kemampuan pembaruan dan kalibrasi secara otomatis untuk mendeteksi keadaan angle of attack dari pesawat aeromodelling.  Software yang digunakan pada penelitian ini terintegrasi dengan indikator LED dan buzzer, selanjutnya dihubungkan dengan servo elevator. LED dan buzzer digunakan untuk memberitahu apabila terjadi kegagalan pembacaan angle of attack antara software dan posisi aktual pesawat. Hasil penelitian menunjukkan rancangan software dapat bekerja dengan baik dengan mengintegrasikan XAMPP, website server data, MySQL, dan Apache. Ketika terjadi kegagalan pembacaan sudut angle of attack maka LED dan buzzer akan menyala, kemudian menghubungkan server display ke XAMPP, Apache dan MySQL. Setelah semua terhubung maka kalibrasi akan dilakukan dan data akan dikirim ke sistem pesawat.
ANALISIS KARAKTERISTIK KEAUSAN MATERIAL DENGAN MATRIKS RESIN MENGGUNAKAN FILLER SERAT BAMBU DAN PASIR BESI UNTUK APLIKASI KAMPAS REM
Authors: Mulyani Lili , Setiawan Ferry , Sofyan Edi
Published: July 2022

Kampas rem merpakan komponen yang mempunyai fungsi memperlambat atau menghentikan laju kendaraan. Saat ini kendaraan bermotor pada umumnya memiliki kecepatan yang sangat tinggi seiring dengan kemajuan teknologi pada kendaraan bermotor. Perkrmbangan teknologi  material telah menghasilkan jenis material baru yaitu komposit yang merupakan campuran antara 2 bahan atau lebih dirancang untuk mencapai kombinasi  sifat terbaik material. Pada penelitian ini yaitu membuat kampas rem dngan menggunakan bahan komposit yaitu pasir besi, resin, dan juga serat bambu dengan menggunakan variasi volume material. Kemudian di uji keausan untuk mendapatkan kesesuaian sebagai kampas rem yang layak. Hasil pengujian menghasilkan yaitu pada spesimen A & B dengan nilai aus yang sama yaitu 3,06735 x 10-7 mm2/kg dengan variasi 10% serat, 10% pasir dan 80% resin untuk spesimen A dan spesimen B dengan variasi 10% pasir, 25% serat dan 65% resin. Sedangkan nilai keausan yang paling besar adalah pada spesimen E dengan nilai aus 5,0881 x 10-7 mm2/kg. Dengan variasi 25% pasir, 25% serat dan 50% resin.
ANALISIS KEKUATAN STRUKTUR SAYAP KOMPOSIT DENGAN VARIASI MATERIAL ALUMINIUM DAN TITANIUM MENGGUNAKAN METODE ELEMEN HINGGA
Authors: Admin Admin , Putra Ikbal Rizki , Prasetyo Erwan Eko
Published: July 2022

Struktur sayap pesawat terbang berfungsi untuk mentransfer beban-beban yang terjadi pada permukaan pesawat ke bidang lain yang memiliki kekuatan lebih besar sehingga komponen pesawat tidak mengalami kegagalan karena setiap komponen menerima beban yang relatif kecil. Struktur yang dibuat harus memiliki kekuatan maksimal dengan berat seringan mungkin serta memenuhi faktor keamanan (safety factor). Penelitian ini melakukan desain dan analisis kekuatan struktur sayap pesawat dengan memvariasikan beberapa material. Jenis material yang digunakan dalam penelitian ini adalah Komposit TORAY T700SC-12K-50C, Aluminium Alloy 2014 T6 dan Titanium Ti-5553. Material komposit dengan susunan arah serat dimana lamina disusun secara simetris dengan arah serat untuk bagian shell dasar airfoil (0°/30°/90°/-30°/0°), dan untuk arah serat Ribs dan Spars (0°/45°/45°/90°), untuk ketebalan sebesar 0,00021 m atau 0,21 mm, Thickness (ketebalan) dibuat seragam dari wingroot sampai dengan wingtip. Dalam penelitian ini diperoleh Stress dan Displacement pada ketebalan yang seragam dimana dengan pembebanan 1 Mpa untuk material komposit dan ketebalan yang seragam 0,21 mm adalah 76.200 Mpa, Aluminium Alloy 2014 T6 pada nilai 87.510 MPa dan untuk Titanium sebesar 87.740 MPa.
PENGUJIAN TEMPERATUR ESC MENGGUNAKAN PENDINGIN PELTIER TECI-12706 DENGAN METODE EKSPERIMEN
Authors: Admin Admin , Eko Prasetiyo Erwan , Irmawan Erwin
Published: July 2022

Motor listrik pada era modern seperti ini sudah banyak dikembangkan untuk berbagai macam kendaraan, baik kendaraan untuk di darat, laut, maupun udara. Hal ini juga dilakukan sebagai upaya untuk penghematan energi agar lebih efektif dan ramah lingkungan. Dengan teknologi seperti ini transportasi yang berkembang dapat menjangkau tempat ataupun wilayah yang sebelumnya sulit dijangkau. Contohnya seperti UAV, dengan ukuran yang lebih kecil dibandingkan pesawat komersial, UAV dapat lebih mudah menjangkau daerah terpencil. Saat ini UAV juga sudah mulai di kembangkan dari yang menggunakan sistem propulsi tidak elektrik menjadi elektrik. Untuk sistem propulsi elektrik ini membutuhkan sebuah ESC (Electronic Speed Controller), ESC berperan penting dalam mengatur putaran pada BLDC (Brushless DC) motor. Penelitian ini memiliki tujuan untuk melakukan pengujian temperatur pada ESC dan kemudian ditambahkan pendingin peltier untuk melihat perubahan pada RPM, temperatur dan gaya dorong yang dihasilkan. Metode yang digunakan pada pengujian ini adalah metode eksperimen. Pengujian ini menggunakan ESC 300A, kemudian menggunakan termometer untuk pembacaan suhunya. Pada pengujian ini data yang diambil yaitu RPM, thrust, dan temperatur. Data tersebut kemudian dioleh menggunakan excel kemudian dianalisis. Hasil dari pengujian menunjukkan bahwa pada tegangan 25V pada ESC yang belum ditambahkan pendingin menghasilkan temperatur 38,2°C pada RPM maksimal yaitu 3.200 dan gaya angkat yang di hasilkan sebesar 10,8kgf. Kemudian pada tegangan yang sama ESC ditambah pendingin menghasilkan data temperatur 33,1°C. Pada ESC berpendingin ini, RPM maksimal yang dihasilkan lebih tinggi yaitu sebesar 3.300 RPM dibandingkan dengan ESC yang tidak menggunakan pendingin. Kenaikan RPM ini juga dapat menghasilkan gaya angkat yang lebih besar yaitu sebesar 11kgf.
THE EFFECT OF PRESS MEDIA FROM CERAMIC AND METAL MATERIALS ON THE TENSILE STRENGTH OF RECYCLED POLYPROPYLENE FOR THE DEVELOPMENT OF COMPOSITE MATRIX MATERIALS
Authors: Admin Admin , Setiawan Hery , Sehono Sehono , Tua Pranata Maruli
Published: July 2022

Composites generally consist of fiber (filler) and resin (matrix). Resin from recycled polypropylene (plastic) polymer was chosen because it has superior properties compared to other types. The manufacturing process with a hot air melting temperature (heat gun) of 300oC was chosen with two variations of  press media, namely metal and ceramic, to compare the mechanical properties of tensile strength. Specimens were shaped according to the ASTM D638 standard. The results showed that the recycled polypropylene with ceramic press media had an average tensile stress of 15.05 MPa, which was higher than that of compressed metal media of 13.06 MPa.
ANALISIS WAKTU PELAPISAN NIKEL PADA ALUMINIUM ALLOY 2024 TERHADAP UJI KEKERASAN VICKERS DENGAN MENGGUNAKAN PROSES ELEKTROPLATING
Authors: Admin Admin , Sehono Sehono , Setiawan Ferry
Published: July 2022

Elektroplating adalah metode finisihing yang digunakan untuk menaikkan sifat dan tampilan dari logam, hal ini dikarenakan logam utama akan dilapisi oleh ion-ion logam jenis lain. Dengan adanya proses elektroplating dapat memberikan sebuah metode yang relatif mudah dan murah untuk menaikkan sifat dan tampilan dari logam. Prinsip dasar dari elektroplating adalah logam yang ada dibagian katoda akan melepaskan ion-ion untuk selanjutnya menempel pada logam yang dihubungkan dengan anoda. Proses ini akan berjalan secara terus menerus sampai dengan arus listrik yang dialirkan dimatikan. Pada penelitian ini dilakukan proses elektroplating dengan menggunakan aluminium 2024 sebagai logam utama dan nikel seabagai logam pelapis. Variasi dari waktu yang digunakan pada proses elektroplating adalah 20 menit, 30 menit, dan 40 menit. Setelah dilakukan proses elektroplating maka selanjutnya aluminium dilakukan uji kekerasan untuk mengetahui dampak dari variasi waktu proses elektroplating. Dari hasil pengujian kekerasan menggunakan metode Hardness Vickers maka spesimen dengan nilai tertinggi terdapat pada variasi waktu 20 menit dengan nilai 328,11 kgf/mm, sedangkan yang paling rendah terdapat pada variasi 40 menit dengan nilai 140.445 kgf/mm. Dari hasil foto mikro juga menunjukkan bekas indentor pada variasi 40 menit memiliki lubang terbesar sedangkan pada waktu 20 menit yang paling kecil. Sehingga semakin lama dari proses elektroplating akan menurunkan nilai kekerasan dari aluminium alloy 2024 yang dilapisi dengan nikel.
Վրաստանի քաղաքական իրավիճակի նկարագրությունը Ստ. Բուռնաշևի պատմագիտական երկում
Authors: Մխիթարյան Գոհար
Published: July 2022

The article considers political condition of Georgia before conclusion of Georgievskiy treaty in 1783. The round of problems related to definition of the place of Georgia within the regional realities of 1750–1770s – relations of the King of Kartli-Kakheti Irakli II with Dagestan rulers and "Adrebijan khans" is presented in the article. The author examines the valuable contribution of some specialists in this field and focuses on the achievements of H. Papazian. The article considers the methods of work and main principles of publiccation of Persian documents in Soviet Union, which were the basis also for Papazian’s work. The author draws also some aspects for future developments in this field.
A History of the Geology Program at New Mexico State University: 1890 to 2015
Authors: Giordano Thomas H.
Published: July 2022

The history behind the Department of Geological Sciences at New Mexico State University goes back one hundred and thirty years and is complex. This history, as told in the pages of this monograph, documents the important details behind the founding of the NMSU geology program and its growth and evolution to 2015. The program's history is conveniently divided into three administrative phases. Phase I comprises the first 55 years, during which the program's activities were managed by one or two regular academic departments of the University. In the Earth Sciences phase, the geology program was administered as a division, along with one or two other divisions in the same department. In its third phase, the geology program became a regular academic department within the College of Arts and Sciences, its current status as the Department of Geological Sciences. Two obvious legacies of NMSU's geology program are the Department of Geological Sciences and the geophysics program in the Department of Physics. However, the program's legacy is also reflected in the students who have taken its courses and the program's research output through the efforts of its faculty, graduate students, and undergraduate students. Since the mid-1960s, the geology program has produced a vast amount of research that has led to a sophisticated understanding of the geology of southern New Mexico and adjacent areas. Finally, through a better understanding of the geology program's academic evolution, the program's alumni and current students, faculty, and staff will have a more profound appreciation of their academic experience at New Mexico State University
Importance of English language for medical students
Authors:   Teaching University Geomedi, Gvenetadze Nana
Published: July 2022

English plays a vital role in medical studies and forges the path for medical students to deepen their knowledge with updated medical information, books, articles, and the latest research, which are primarily available in English language, but that is not all. Medical students need to study English to pursue careers in the healthcare field, where the knowledge of this language can be crucial at times, therefore, English is essential for academic and professional purposes. The following review article aims to discuss the importance for medical students and doctors to learn English in order to develop in different settings, the Benefits of knowing professional English in the Healthcare field, and the Drawbacks of not understanding the English language.
Filary (zasady) prawa autorskiego w orzecznictwie Trybunału Sprawiedliwości Unii Europejskiej z lat 2016 – 2017 na tle współczesnych trendów w prawie prywatnym
Authors: Przybytek Piotr , Przybytek Paweł
Published: July 2022

Współczesne prawo autorskie musi się zmierzyć z wyzwaniami wynikłymi z dynamicznego rozwoju nowoczesnych technologii. Do zrealizowania ma cztery zadania. Po pierwsze, musi chronić przyrodzone prawo autora do własności rezultatów swojego wysiłku. Po drugie, autor zasługuje na wynagrodzenie za korzystanie z jego pracy, co z kolei stanowi zachętę do tworzenia – będącą trzecią główną zasadą nowoczesnego prawa autorskiego. I wreszcie autorów powinno się zachęcać do publikowania swoich dzieł, gdyż stymuluje to rozwój nauki i kultury. Z powyższych zasad (filarów) przynajmniej trzy pojawiają się w orzecznictwie Trybunale Sprawiedliwości Unii Europejskiej za lata 2016/2017 – I, II i IV. Trybunał stara się przede wszystkim zagwarantować autorom stosowne wynagrodzenie. Jednak podkreśla się trudność odseparowania uprawnień majątkowych i osobistych. I rzeczywiście zaprezentowana analiza prowadzi do wniosku, iż zlewają się one. Już wcześniej podkreślano, że organy Wspólnot wniosły istotny wkład w kształtowanie wzorców ochrony prawa autorskiego będących odpowiedzią na rozkwit nowych technologii. W naszej analizie zauważalna jest tendencja zrównywania prawnego tradycyjnie produkowanych utworów z ich cyfrowymi odpowiednikami.
Linia polityczna gazety „Przełom” Poalej Syjon Lewicy w latach 1946-1949
Authors: Flisiak Dominik
Published: July 2022

Poalej Syjon Lewica była ugrupowaniem reprezentującym skrajnie lewicowy odłam syjonizmu. Jej członkowie opowiadali się za sojuszem ze Związkiem Socjalistycznych Republik Radzieckich i doceniali zmiany zachodzące w powojennej Polsce. Aktywiści Poalej Syjon Lewicy optowali za powstaniem w Palestynie jednego, dwunarodowego państwa i z szacunkiem podchodzili do dorobku kultury języka jidysz. W powojennej Polsce stronnictwa żydowskie drukowały gazety w trzech językach: polskim, hebrajskim oraz jidysz. Gazeta „Przełom” była wydawana od 1946 do 1949 r. Adres wydawniczy znajdował się w Warszawie, numer gazety liczył średnio 12 lub 16 stron. Wśród osób publikujących artykuły byli m.in. Adolf Berman, Henryk Wasser oraz Leopold Weber.
Madawi al-Rasheed (ed.), Salman’s Legacy. The Dilemmas of a New Era in Saudi Arabia, Wydawnictwo Oxford University Press, Oxford 2020, ss. 367
Authors: Pietrasik Kamil
Published: July 2022

Recenzja: Madawi al-Rasheed (ed.), Salman’s Legacy. The Dilemmas of a New Era in Saudi Arabia, Wydawnictwo Oxford University Press, Oxford 2020, ss. 367
Lactobacillus Use for Plant Fermentation: New Ways for Plant-Based Product Valorization
Authors: Le Rouzic Morgan , Bruniaux Pauline , Raveschot Cyril , Krier François , Phalip Vincent , Ravallec Rozenn , Cudennec Benoit , Coutte François
Published: July 2022

Today, plant production is increasing, but most industrial processes generate a lot of waste and by-products for which, in the current context, it is a priority to recycle or valorize them. One of the cheapest valorization routes is fermentation, in particular lactic fermentation by Lactobacillus species, which produces lactic acid and other molecules of industrial interest such as bioactive compounds such as anthocyanin, organic acid, peptides, or phenol, which are widely found in the plant matrix, mainly in cereals, grass, fruits, and vegetables. Bioactive compounds may exert beneficial health effects, such as antioxidant, anti-inflammatory, antimicrobial, or prebiotic activities. In addition, lactic acid fermentation can improve existing products and lead to new applications in food, livestock feeding and biotechnology, such as the production of lactic acid, protein, or silage. This chapter reviews the use of Lactobacillus strains in the fermentation process of many plant bioresources or by-products through their different bioactivities, active molecules, and applications.
Simple and Fast DNA-Based Tool to Investigate Topoisomerase 1 Activity, a Biomarker for Drug Susceptibility in Colorectal Cancer
Authors: Geertsen Keller Josephine , Vandsø Petersen Kamilla , R. Knudsen Birgitta , Tesauro Cinzia
Published: July 2022

With the increased effort for identification of anticancer compounds, there is a growing need for tools to investigate the activity of enzyme biomarkers. Human topoisomerase 1 is the only target of the camptothecin derivatives, and the cellular drug response depends on the enzyme activity. Here we use the colon cancer cell line Caco2 to investigate the topoisomerase 1 activity using a simple and improved version of our rolling circle enhanced enzyme activity detection, the REEAD assay. We present two fast readout methods that do not require the use of specialized training or equipment. In this setup, topoisomerase 1 converts specific DNA substrates to closed circles. The circles are amplified by rolling circle amplification in the presence of biotinylated nucleotides allowing for the detection of the products using horse radish peroxidase conjugated anti-biotin antibodies. The visualization occurs by either ECL or by color development through the precipitation of the TMB onto the surface. The presented readouts allow for fast and sensitive screening of topoisomerase 1 activity in extracts from Caco2 cells, potentially enabling the patients’ stratification and the prediction of the chemotherapeutic response for individualized treatment. For these reasons, we believe that the presented method would be easily adaptable to the clinical settings.
Cutaneous Manifestations and Their Corresponding Dermoscopic Features in Patients with Dermatomyositis
Authors: Pozharashka Joana , Miteva Ljubka , Dourmishev Lyubomir
Published: July 2022

Introduction: Dermoscopy is a noninvasive and easy to apply technique that allows in vivo magnification of the skin and thus observation of morphologic structures invisible to the naked eye. Recently, it gained popularity for evaluation of inflammatory skin conditions. In the field of connective tissue diseases, dermoscopy has been used mainly as a simple and accessible substitute of nailfold capillaroscopy.
Objectives: The aim of the present study is to expand the application of dermoscopy in patients with dermatomyositis (DM) beyond the usual nailfold examination. A clinico-dermoscopic correlation is also suggested.
Methods: A total of twenty-nine patients with DM were enrolled in this descriptive prospective study, conducted over a three-year period. Dermoscopy was performed by a DermLite DL1 dermatoscope on polarization mode, attached to One Plus 3T camera. The following skin lesions were examined - periungual affection, scalp DM, Gottron’s papules, palmar papules, poikiloderma and auricular changes.
Results: Dermoscopy detected predominantly advanced nail fold capillary changes - giant capillaries (79%), microhemorrhages (46%) and avascular areas (25%). The most prevalent trichoscopic features were enlarged tortuous capillaries (64%), interfollicular scales (50%) and peripilar casts and tufting (36%). Among the other skin lesions assessed in this study - Gottron's papules were present in 20 patients, poikiloderma in 11, palmar papules in 4 and auricular lesions in 4 patients.
Comparison of early (EOP) and late onset psoriasis (LOP) regarding systemic inflammatory comorbidities: LOP is a more rapid subtype of psoriasis
Authors: Huseynova Terzi Leyla , Dogan Gunaydin Sibel
Published: July 2022

Background: Early onset psoriasis (EOP) and late onset psoriasis (LOP) differs regarding genetic background, clinical presentation, and course of disease.

Objective: In this study, comparison of EOP and LOP regarding systemic inflammatory comorbidities which are frequently seen in psoriasis and determination of possible differences is aimed.

Methods: A total of 160 plaque psoriasis patients; 121 with EOP and 39 with LOP were enrolled for the study. Data was collected with face-to-face questionnaire and patients’ medical chart evaluation. Collected data included medical and family history, clinical features and parameters indicating severity of psoriasis, results of laboratory work-up, physical and dermatological examination findings, presence of joint and nail involvement and associated inflammatory systemic comorbidities such as cardiovascular diseases (CVD), diabetes mellitus (DM), hypertension (HT), metabolic syndrome (MS), obesity.

Results: Nail involvement and PsA occurred more rapidly in LOP compared to EOP (p<0.01, p<0.01). Compared frequencies in LOP and EOP were 7.7% vs 0.8% for CVD, 38.5% vs 14% for HT, 33.3% vs 9.9% for DM and 44.7% vs 24.8% for MS respectively. CVD, HT, DM and MS were significantly more frequent in LOP compared to EOP (p=0.045, p=0.001, p<0.01, p=0.022). Results of multivariate analysis performed taking into account the age, gender, severity parameters of disease, alcohol consumption, smoking habits, and other concurrent systemic comorbidities revealed LOP to be an independent risk factor for CVD and DM (p<0.01, R2: 0.036, p<0.01, R2: 0.077).  

Conclusion: LOP seems to interact with systemic comorbidities hence generating more severe inflammatory burden and shows a more rapid course.
Evaluation of MCV/RDW Ratio and Correlations with Ferritin in Telogen Effluvium Patients
Authors: İbiş Saadet , Aksoy Saraç Gülhan , Akdağ Turan
Published: July 2022

Objective: Telogen effluvium is one of the chronic diseases that affect the quality of life (QoL) in women. The study aimed to evaluate the RDW/MCV ratio and its correlation with ferritin in Telogen Effluvium patients and to reveal their potential role in the etiopathogenesis of Telogen effluvium.

Material and Methods: We retrospectively evaluated the medical data of 250 patients who were admitted to the dermatology outpatient clinic between September 2020 and December 2020 with a diagnosis of Telogen effluvium. The control group was created retrospectively from the medical records of 250 healthy individuals. HB, HCT, MPV, MCV, RDW, ferritin, and MCV/RDW ratio of both groups were compared and evaluated statistically.

Results: All of the Telogen effluvium patients were women in terms of gender. The mean age of the patient group was 33,11±9,66 years and the mean age of the control group was 34,98±12,37 years. The ratio of MCV/RDW, MPV, MCV, and ferritin is lower in the group with Telogen effluvium compared to the control group and a statistically significant difference was found(p<0.05). However, the correlation between MCV/RDW ratio and ferritin was evaluated in Telogen effluvium patients, and no significant differences were found (p>0.05).

Conclusion: Iron deficiency anemia is thought of as a factor in female patients with telogen effluvium. Although the data shows the correction of iron deficiency is insufficient telogen effluvium, we proposed that laboratory tests should be routinely used in the diagnosis and treatment phase of patients who apply with the complaint of hair loss.
Sonographic Characteristics of Leiomyomatous Tumors of Skin and Nail—A Case Series
Authors: Taleb Eyal , Saldias Cristobal , Gonzalez Sergio , Misad Carlos , Wortsman Ximena
Published: July 2022

Introduction - The clinical appearance of the uncommon cutaneous leiomyomatous tumors (LMT) is nonspecific, leading to an extensive differential diagnosis. A non-invasive tool such as high-frequency ultrasound (HFUS) is required for characterizing LMTs in the clinical setting. Although the sonographic features of their uterine counterpart had been well reported, there are only scant reports on the use of ultrasound (US) for studying leiomyomatous neoplasms of the skin and nail.

Objectives and methods – We Characterized common sonographic features of LMT using HFUS in three patients, two of them with multiple cutaneous leiomyomas and another with a subungual leiomyosarcoma.

Results – In all cases, several shared ultrasound (US) characteristics were found. Moreover, we describe a new ultrasonographic sign in cutaneous leiomyomas called the “pine tree” sign, with other features not previously reported.

Conclusion - These ultrasonographic characteristics would strengthen the clinical diagnosis, assist with treatment management, and may help avoid serial biopsies in cases with multiple cutaneous lesions.
Sociedades de crédito ao microempreendedor e às empresas de pequeno porte: desenho institucional versus eficiência?
Authors: Dodl Alessandra , Carvalho João Carlos de
Published: July 2022

Este artigo visa analisar os resultados das SCMEPPs, com base em seus indicadores contábeis e operacionais, com o intuito de jogar luz sobre a adequação de seu desenho institucional. Seria o momento de discutir a mudança de regras do segmento, ou ainda, sua permanência sob a regulação/supervisão do Banco Central do Brasil.
Pervivencia de la ideología egipcia del león en la emblemática de Hieroglyphica de Horapolo
Authors: Hernández Figueroa María Isabel
Published: July 2022

Horapolo en Hieroglyphica trata de desentrañar el significado ya perdido de los jeroglíficos egipcios, y si bien su trabajo no es de tipo lingüístico, acierta a recoger algunos comportamientos característicos del león utilizados en la tradición egipcia. Dicha tradición tiene algunas ideas referidas al poder o la fuerza a partir del león, que vincula al monarca. El objetivo de este estudio es ver cómo estos significados se desarrollan desde lo pagano hacia lo cristiano a través de Hieroglyphica, dando lugar a la creación de otros significados como la valentía o la vigilancia que son tan apreciados en el hombre cristiano, y que incluso perviven en el arte moderno.
El doble efecto de la pandemia en el discurso transhumanista
Authors: García-Barranquero Pablo , Diéguez Antonio
Published: July 2022

La pandemia de la covid-19 ha puesto de manifiesto una vulnerabilidad parcialmente olvidada. Este período tan hostil nos ha hecho ser más conscientes de la finitud de nuestra vida y de los peligros a los que estamos expuestos por ser el organismo biológico que somos. Ante tal panorama, el transhumanismo ha aprovechado la coyuntura para proclamar, con más fuerza que nunca, los beneficios que tendría la aplicación de las nuevas tecnologías en el propio ser humano. Sin embargo, al mismo tiempo, los detractores de este movimiento han señalado, con la misma intensidad, cómo la pandemia ha debilitado muchas de sus promesas. Nosotros mostramos cómo tanto los primeros como los segundos siguen manteniendo posiciones radicalmente distintas en torno a qué se debe hacer con respecto a la vulnerabilidad, pero ambos han visto la oportunidad en esta pandemia para iluminar cuál debe ser la dirección correcta para el futuro de nuestra especie. Este acontecimiento, no afincado en los terrenos de ciencia-ficción, puede llegar a ser decisivo para repensar los grandes retos que (aún) nos esperan.
La materia oscura y los traumas europeos (1800-2020)
Authors: Ribes Alberto Javier
Published: July 2022

Durante la modernidad, en los últimos doscientos años, se produjo una laguna en la teoría social, un espacio que era visible para los contemporáneos, pero que no fue integrado con rotundidad en el centro de las reflexiones sobre lo social: nos referimos a lo que aquí denominamos la materia oscura de la modernidad. Este artículo tiene como objetivo poner de manifiesto ese vacío, la manera en que se abordó y se ha venido abordando, así como proponer una definición de dicho concepto. En un segundo momento realizaremos un análisis de los traumas europeos del siglo xx y la relación de ambos con la materia oscura, subrayando la importancia de los aceleradores intensivos de la violencia.
UHPLC-HRMS Based Saponin and Flavonoid Profiling of Chenopodium bonus-henricus L. Roots and Prolipase Activity of the Main Saponins
Authors: Kokanova-Nedialkova Zlatina , Nedialkov Paraskev
Published: July 2022

UHPLC-HRMS profiling method was used for a comprehensive study of flavonoid and saponin-rich fractions from the MeOH extract of C. bonushenricus L. roots. Thirty-one compounds, respectively, 16 saponins of five sapogenins (oleanoic acid, 2-hydroxyoleanoic acid, medicagenic acid, bayogenin, and phytolaccagenin), together with 15 flavonoid glycosides of 6-methoxykaempferol, isorhamnetin, spinacetin, and patuletin were detected. Lipase modulatory activities of the main saponins were established by measuring the levels of the released 4-nitrophenol using LC-MS. All saponins exhibited prolipase activity and could find application in the treatment of cachexia.
Production of Functional Recombinant Human Interferon-gamma by RTX CPD-fusion Technology
Authors: Krachmarova Elena , Nacheva Genoveva
Published: July 2022

Human interferon-gamma (hIFNγ) is an important pleiotropic cytokine with therapeutic application. Recombinant hIFNγ has been shown to be an effective pharmaceutical against a wide range of viral, immuno-suppressive diseases with promising prospects in cancer immunotherapy resulting in a strong increase in demand and price. The aim of this study was to develop an efficient method for production of soluble and active hIFNγ. To this end a fusion gene encoding hIFNγ and a C-terminally located His10-tagged RTX CPD was constructed by two-step PCR. The fusion gene was cloned in an expression vector under inducible promoter and expressed in different E. coli strains such as Rosetta (appropriate for expression of eukaryotic genes containing rare codons), and two chaperone containing strains – BL21(DE3)/pG-KJE8 and BL21(DE3)/pG-Tf2. The transformed bacteria were cultivated at 24℃ to favour proper folding of the recombinant protein. Under these conditions the strain BL21(DE3)/pG-KJE8 was chosen as more suitable for production of soluble hIFNγ. The latter was purified by Ni2+- based affinity chromatography, the peak fractions were subjected to affinity chromatography combined with a direct on-column digestion to release hIFNγ, which was further purified by ion exchange chromatography. It is worth mentioning that this strategy, employing auto-cleaving and solubility-enhancing CPD tag, combined with on-column tag digestion was applied for the first time for production of hIFNγ.
Effectiveness and Safety of Treatment with Nucleo(s)tide Analogues in Patients with Hepatitis B-related Cirrhosis
Authors: Gerdzhikova Klimentina , Donkov Ivo , Komitova Teodora , Genov Jordan , Vladimirov Borislav , Mitova Rumyana , Chetirska Milena , Asenova Boryana , Bedran Ali , Pavlov Kaloyan
Published: July 2022

Data from Bulgaria are limited on the long-term effects of nucleo(s)tide analogues (NAs) to patients with hepatitis B-related cirrhosis. The study aimed to evaluate the overall efficacy and renal safety of NAs in such cohort of patients, comparing treated with high to low-barrier NAs. We retrospectively analyzed 58 patients with HBV cirrhosis (74.1% in compensated stage) for a period of 5 years. Thirty-five patients received NAs with high-barrier of resistance: Tenofovir disoproxil fumarate and Entecavir (followed up for 51.63 ± 30.3) and 23 received NAs with low-barrier of resistance: Lamivudine and Telbivudine (followed up for 56.7 ± 48.4). After a median treatment time of 53.7 months virological response (VR) rates (HBV DNA<10 IU/ml) were 91.4% in high barrier and 87.0% in low barrier NAs groups. Undetectability of HBVDNA was influenced most by the treatments’ duration. Serological response reached 57.1%, similar for the two treatment groups. One patient (1.7%) cleared HBsAg and discontinued NAs (TDF). Multidrug resistance (MDR) occurred in 15.5% of LAM recipients only. One-, 3-, 5-, 8- year MDR rates were 0.0%; 11.1%; 33.3% and 77.6%. A slight improvement of the renal function was observed in 85.7% and 69.6% of the patients treated with high and low-barrier NAs. Dose reduction for renal toxicity was required in 1.7%. Decompensated cirrhosis and T2DM were the main risk factors for renal function decline. Long-term therapy with high and low barrier NAs was equally effective and renally safe in patients with HBV-related cirrhosis.
Fighting ability, personality and melanin signalling in free-living Eurasian tree sparrows (Passer montanus)
Authors: Fülöp Attila , Németh Zoltán , Kocsis Bianka , Deák-Molnár Bettina , Bozsoky Tímea , Kőmüves Gabriella , Barta Zoltán
Published: July 2022

Background

Individuals’ access to resources is often decided during dyadic contests the outcome of which is determined by the fighting (or competitive) ability of the participants. Individuals’ fighting ability (termed also as resource-holding power or potential, RHP) is usually associated with individual features (e.g., sex, age, body size) and is also frequently signalled through various ornaments like the black throat patch (bib) in many birds. Individual personality is a behavioural attribute often linked to fighting ability as well. Based on earlier studies, however, the relationship between personality and fighting ability is far from being straightforward. While accounting for sex and body size, we studied whether exploratory behaviour, an aspect of personality, predicts fighting ability when competing for food during winter in free-living Eurasian tree sparrows (Passer montanus). We also investigated whether the bib can serve as a potential indicator of individual competitiveness in this species.

Methods

We captured adult tree sparrows, marked them with a unique combination of colour rings, and collected data about the individuals’ sex, body size, bib size and exploratory behaviour. Birds were then released and the agonistic behaviour of the marked individuals was recorded while foraging in groups on bird feeding platforms.

Results

The probability of winning a fight, a proxy for fighting ability of individuals, was not related to exploratory behaviour, in either of the sexes. However, bib size was positively related to probability of winning in females, but not in males. Body size was not associated with probability of winning neither in males, nor in females.

Conclusions

Our results suggest that, at least in tree sparrows, the outcome of dyadic encounters over food during the non-breeding period are not determined by the exploratory personality of individuals. However, our findings provide further support for a status signalling role of the black bib in tree sparrows, and hint for the first time that bib size might function as a status signal in females as well. Finally, our results do not confirm that body size could serve as an indicator of fighting ability (i.e., RHP) in this species.
La violencia perversa en contextos educativos. Desafíos para el Trabajo Social
Authors:   Facultad de Trabajo Social, Universidad Autónoma de Coahuila (México), Salazar González Vastí Atalía , Acevedo Alemán Jesús ,   Universidad Autónoma de Coahuila (México)
Published: July 2022

La violencia perversa son aquellas prácticas o tácticas sutiles de agresión, encaminadas a destruir moral y psicológicamente a una persona, a través de palabras hirientes, mentiras, sarcasmos, descalificaciones, humillaciones, ironías, insinuaciones o miradas inquisitivas, manipulación, denigración, acoso, indiferencia, hostilidad, intimidación, entre muchas otras formas de agresión imperceptibles en la mayoría de las ocasiones. Dicha forma de violencia no respeta condición social, económica, o política, ni mucho menos género o edad, la pueden sufrir tanto adultos, como niños en cualquier contexto sea este familiar, social o escolar. En tal sentido, el objetivo del presente texto es describir las prácticas de intimidación que se viven en 67 Escuelas primarias de la Ciudad de Saltillo, Coahuila, México. Concluyéndose después de entrevistar a 1.307 niños de entre 10 y 14 años que la violencia perversa está presente, y diluida entre las conocidas como prácticas o conductas de intimidación o bullying. Reconocidas como parte del marco de la violencia perversa; que requiere de que los profesionales de la educación, administrativos y trabajadores sociales vinculados al escenario educativo se habiliten sobre este fenómeno. Para identificarlo en principio, e incentive en segundo momento, a generar protocolos efectivos de prevención y atención.
Marcos que guían las acciones colectivas solidarias en contexto de pandemia en la ciudad de Talca (Chile)
Authors:   Universidad Católica del Maule, Talca (Chile), Figueroa Toledo Nicolás , Concha Saldias Claudia ,   Facultad de Ciencias Sociales y Económicas, Universidad Católica de Maule, Talca (Chile)
Published: July 2022

Este artículo explora los marcos que guían las acciones colectivas solidarias de tres organizaciones ciudadanas en Talca (Chile), durante la crisis socio sanitaria provocada por el COVID-19. Estas acciones son parte de diversas expresiones que desarrollan las orgánicas comunitarias, para satisfacer las necesidades de producción y reproducción de la vida social. Desde la propuesta de Gamson y Meyer (1999), se indaga en los componentes que guían la acción colectiva. La metodología utilizada es de corte cualitativo debido a que requiere explorar en las experiencias y motivaciones que orientan las acciones. Se optó por el estudio de casos múltiples, y la información se obtuvo a través de entrevista grupales en modalidad virtual y presencial. Los resultados muestran, que las acciones colectivas solidarias se conciben como reparaciones sociales, económicas y afectivas, que surgen desde la autogestión, producto de la ausencia o débil funcionamiento de la institucionalidad pública, y la precarización de la vida como consecuencias del Estado neoliberal. Se identifica como componente movilizador la lucha por la dignidad, y se evidencia que las acciones colectivas solidarias son una respuesta a la crisis del cuidado, abriendo el debate respecto al reparto de responsabilidades en la sociedad y la frágil red de protección social.
Observational Study of Covid-19 Cases and Off-label Drugs to Manage Complications during First and Second Wave
Authors: Das Sushantha Kumar , Doddikindi Nanditha , Thoda Prathyusha , Jindam Shashank , Vajenepalli Sai Harshitha , Rao T. Rama
Published: July 2022

Background: Initially Covid-19 complication treatment was almost nil and focused only on supportive measures. Various off-label drugs were utilized globally to obtain better outcomes; the same was practiced by the Indian healthcare fraternity. We have aimed to review the utilization of off-label medicines like Vitamin C, Azithromycin, Ivermectin, Doxycycline, Low Molecular Weight Heparin, Zinc, Remdesivir, Dexamethasone, etc. prescribed in Covid-19 nodal hospital of Telangana state, India.

Methodology: A retrospective review and prospective observational study were conducted in the Covid-19 units of Gandhi medical college and hospital, Secunderabad between December 2020 and May 2021. The study was conducted after obtaining the necessary permission. In a retrospective review; previously published reports were analyzed to correlate the off-label medicine prescription for Covid-19 complications. Prospective case analysis was performed to access the outcome of drugs prescribed in Covid-19 complication and identified as off-label.

Results: A total of 60 prescriptions were analyzed. Among these; Vitamin-C, Dexamethasone, and Azithromycin were prescribed in 67%, 43%, and 37% cases respectively. The study further revealed that hypertension and diabetes mellitus were the two most commo  comorbidities that lead to hospitalization and subsequently required aggressive treatment to manage the Covid-19 related complications. Bilateral pneumonia was the most frequently appearing complication and therefore Dexamethasone and Azithromycin were listed as top off-label drugs to manage the same.

Conclusion: Due to the lack of specific treatment available initially to manage Covid-19 complications, off-label medicines not only aided enormously in recovering from the complication but also demonstrated to the world that the right choice of off-label medicine can greatly reduce the risk.
Mammaglobin 1 mediates progression of trastuzumab‐resistant breast cancer cells through regulation of cyclins and NF‐κB
Authors: Kusumastuti Ratih , Kumagai Yuji , Ishihara Seiichiro , Enomoto Atsushi , Murakami Takashi , Yasuda Motoaki , Haga Hisashi
Published: July 2022

Overexpression of human epidermal growth factor receptor 2 (HER2) in various cancers is correlated with poor patient survival. Trastuzumab, a recombinant humanized monoclonal antibody against HER2, has been considered to be a first‐line therapy for HER2‐positive breast cancer patients, but its usefulness is limited by the development of resistance. In this study, we established resistant cells by long‐term treatment with trastuzumab. These cells showed higher proliferation, invasion, and migration abilities than the wild‐type cells. Mammaglobin 1 (MGB1), cyclin D1, E1, A2, and phosphorylated NF‐κB (p‐p65) were upregulated in resistant cells. These proteins regulate cell proliferation, migration, and invasion of resistant cells. Depletion of MGB1 decreased cyclin and p‐p65 expression. Cyclin D1 and A2, but not E1 expression, were affected by p‐p65 downregulation. In summary, our results indicate that MGB1 expression is increased in breast cancer cells that have gained resistance to trastuzumab, and suggest that MGB1 promotes aggressiveness through cyclin and NF‐κB regulation.
Amyloidogenicity assessment of transthyretin gene variants
Authors: Grether Nicolai B. , Napravnik Felix , Imhof Thomas , Linke Reinhold P. , Bräsen Jan H. , Schmitz Jessica , Dohrn Maike , Schneider Christian , Svačina Martin K. R. , Stetefeld Jörg , Koch Manuel , Lehmann Helmar C.
Published: July 2022

Objective

Hereditary transthyretin‐mediated amyloidosis is a treatable condition caused by amyloidogenic variants in the transthyretin‐gene resulting in severe peripheral neuropathy or cardiomyopathy. Only about a third of over 130 known variants are clearly pathogenic, most are classified as variants of uncertain significance. A clear delineation of these into pathogenic or non‐pathogenic is highly desirable but hampered by low frequency and penetrance. We thus sought to characterize their amylogenic potential by an unbiased in vitro approach.

Methods

Thioflavin T and turbidity assays were used to compare the potential of mammalian cell expressed wt‐transthyretin and 12 variant proteins (either variants of uncertain significance, benign, pathogenic) to aggregate and produce amyloid fibrils in vitro. As proof of principle, the assays were applied to transthyretin‐Ala65Val, a variant that was newly detected in a family with peripheral neuropathy and amyloid deposits in biopsies. In silico analysis was performed to compare the position of the benign and pathogenic variants.

Results

Transthyretin‐Ala65Val showed a significantly higher amyloidogenic potential than wt‐transthyretin, in both turbidity‐ and Thioflavin T‐assays, comparable to known pathogenic variants. The other eight tested variants did not show an increased amyloidogenic potential. In silico structural analysis further confirmed differences between pathogenic and benign variants in position and interactions.

Interpretation

We propose a biochemical approach to assess amyloidogenic potential of transthyretin variants. As exemplified by transthyretin‐Ala65Val, data of three assays together with histopathology clearly demonstrates its amyloidogenicity.