bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimación de la calidad de la dieta en sistemas silvopastoriles mediante la cuantificación del nitrógeno fecal
Authors: Portilla-Pinzón Danilo , Barragán-Hernández Wilson , Carvajal-Bazurto Christian , Cajas-Girón Yasmin
Published: January 2019

Con el objeto de evaluar la calidad de la dieta consumida por bovinos en sistemas silvopastoriles (SSP), mediante su estimación a través del nitrógeno fecal (NF), se compararon cuatro arreglos que variaron en su composición vegetal, con especies arbustivas (L. leucocephala y C. cujete), arbóreas (A. saman, G. ulmifolia y C. grandis) y maderables (P. quinata y S. macrophylla), contra un tratamiento sin árboles (M. maximum). A cada tratamiento fueron asignadas 4 vacas Romosinuano x Holstein x Cebú (436±64,2 kg) a las cuales se les colectó heces vía rectal. Las muestras de heces fueron secadas y sometidas a análisis de nitrógeno (total, soluble e insoluble en FDN), FDN y materia orgánica (MO). Con el NF se estimó la cantidad de proteína fecal (PCF), proteína cruda (PC) y la digestibilidad de la dieta consumida en cada SSP. Se observó efecto significativo (p<0.01) del tratamiento sobre la cantidad de NF, presentado como PCF. El tratamiento Pasto-Arbust-Arbor-Mad obtuvo un valor de 132.19 g.kg MO-1, con diferencia significativa de los tratamientos Pasto, Pasto-Arbus y Pasto-Arbor, con registros de 119.77, 116.77 y 118.91 g.kg MO-1 respectivamente. No se registró efecto del tratamiento en las fracciones de MO, FDN y el contenido de nitrógeno soluble e insoluble en FDN. La digestibilidad y la PC de la dieta consumida estimada a través del NF varió de 61.45% a 65.24% y de 10.28% a 12.02% respectivamente. La cuantificación del NF permitió revelar la calidad de la dieta que consumen los bovinos en ambientes SSP de estructura vegetal compleja.
Exploration of Proteins Involved in Acquisition of Resistance to Cetuximab
Authors: Nakamura Hironori , Nagamine Ayumu , Yashima Hideaki , Araki Takuya , Yamamoto Koujirou
Published: January 2019

Anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (Mabs) show high efficacy in about 50% of colorectal cancer (CRC) patients with wild-type KRAS. However, < 20% of patients with KRAS wild-type CRC have continued therapeutic effects with these agents, and acquired resistance to treatment has become a serious clinical problem. In this study, to clarify the factors related to acquisition of resistance to cetuximab (Cmab) and establish countermeasures against such acquired resistance, we conducted a comprehensive protein analysis via a proteomics approach using acquired resistance cell lines derived from Cmab-sensitive CRC cell lines and original cell lines. Cmab-acquired resistance cell lines were generated by continuous exposure of SW48 and C99 cell lines to Cmab. Expression of dCK and zinc finger and BTB domain-containing protein 41 (ZBTB41) increased more than 10-fold, and dual specificity protein phosphatase 3 (DUS3) expression decreased by less than 1/10 with acquisition of resistance to Cmab in both C99 and SW48 cell lines. Because overexpression of dCK is known as a positive indicator of efficacy of nucleoside analogs such as cytarabine or gemcitabine, it is considered that nucleoside analogs activated by dCK may be useful agents in treatment of cancers with acquired Cmab-resistance. In the future, we need to clarify the usefulness of these drugs for the treatment of Cmab resistant CRC and to assess the possibility of restoration of Cmab sensitivity by regulation of ZBTB41 and DUS3 expression.Keyword : cetuximab, colorectal cancer, acquired resistance, protein, dCK, ZBTB41
Thatbiq Hifdz al-Mufradat li Taarqiyyah Maharah al-Imla' Laday Thalabah al-Madrasah al-Tsanawiyyah al-Mutakamilah Hidayatullah Palopo
Authors: Mahmud Muhammad Said
Published: January 2019

AbstrakPenelitian ini berbicara tentang implementasi menghapal kosakata dalam meningkatkan keterampilan imla pada siswa-siswi dari Sekolah Menengah Pertama Integral Hidayatullah Palopo. Metodologi penelitian menggunakan pendekatan deskriptif kuantitatif. Adapun metode pengumpulan data menggunakan wawancara, kuesioner, dokumentasi. Hasil dari penelitian ini adalah: 1. Penerapan menghapal kosakata di sekolah Madrasah Tsanawiyah Integral Hidayatullah Palopo sangat menarik dan menyenangkan siswa. Dalam penerapan metode menghapal kosakata dalam bahasa Arab, guru menuntut tetapi dapat membuat belajar menjadi menarik dan menyenangkan sehingga peserta didik dapat bersemangat dan siap untuk menyerap pelajaran. 2. Keterampilan imla di Sekolah Menengah Pertama Integral Hidayatullah Palopo telah meningkat. Hal ini disebabkan karena dalam pembelajaran guru mampu menjadikan suasana yang menenangkan dan menarik, sehingga keterampilan imla dengan metode hapalan dari siswa-siswi menjadi menigkat. 3. Penerapan hapalan kosakata di Sekolah Menengah Pertama Integral Hidayatullah Palopo sangat berpengaruh dalam kemampuan imla dalam metode pembelajaran yang bertujuan untuk menentukan keberhasilan siswa. Sesugguhnya metode pembelajaran bertujuan untuk memudahkan siswa dalam memahami pelajaran terutama bahasa Arab.Kata kunci: Penerapan metode hapalan kosa kata, maharah imla
Spatiotemporal Aspects of Big Data
Authors: Karim Saadia , Soomro Tariq Rahim , Aqil Burney S. M.
Published: January 2019

Data has evolved into a large-scale data as big data in the recent era. The analysis of big data involves determined attempts on previous data. As new era of data has spatiotemporal facts that involve the time and space factors, which make them distinct from traditional data. The big data with spatiotemporal aspects helps achieve more efficient results and, therefore, many different types of frameworks have been introduced in cooperate world. In the present research, a qualitative approach is used to present the framework classification in two categories: architecture and features. Frameworks have been compared on the basis of architectural characteristics and feature attributes as well. These two categories project a significant effect on the execution of spatiotemporal data in big data. Frameworks are able to solve the real-time problems in less time of cycle. This study presents spatiotemporal aspects in big data with reference to several dissimilar environments and frameworks.
An Efficient Technique for Size Reduction of Convolutional Neural Networks after Transfer Learning for Scene Recognition Tasks
Authors: Romanuke Vadim
Published: January 2019

A complex classification task as scene recognition is considered in the present research. Scene recognition tasks are successfully solved by the paradigm of transfer learning from pretrained convolutional neural networks, but a problem is that the eventual size of the network is huge despite a common scene recognition task has up to a few tens of scene categories. Thus, the goal is to ascertain possibility of a size reduction. The modelling recognition task is a small dataset of 4485 grayscale images broken into 15 image categories. The pretrained network is AlexNet dealing with much simpler image categories whose number is 1000, though. This network has two fully connected layers, which can be potentially reduced or deleted. A regular transfer learning network occupies about 202.6 MB performing at up to 92 % accuracy rate for the scene recognition. It is revealed that deleting the layers is not reasonable. The network size is reduced by setting a fewer number of filters in the 17th and 20th layers of the AlexNet-based networks using a dichotomy principle or similar. The best truncated network with 384 and 192 filters in those layers performs at 93.3 % accuracy rate, and its size is 21.63 MB.
Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia
Authors: Aničić Milan , Vučićević Ivana , Vasković Nikola , Radojičić Sonja , Juntes Polona , Nešić Slađan , Aleksić-Kovačević Sanja , Marinković Darko
Published: January 2019

Canine distemper virus (CDV) is a worldwide distributed RNA virus that can cause severe disease in carnivore and non-carnivore species. Red foxes are highly susceptible and may act as a reservoir of the virus. As in other wild species, distemper in red foxes can manifest as acute, systemic and chronic nervous form. In the present study, we detected antibodies against CDV among red foxes in Western Serbia, and analyzed histopathologically and immunohistochemically for CDV nuclear protein antigen (CDV-NP) brain samples derived from seropositive animals. Seroprevalence of CDV antibodies was 36.8%. Histopathological changes included gliosis, neuronal degeneration, satellitosis, mononuclear inflammation, demyelination and presence of inclusion bodies. Immunostaining showed a diffuse presence of CDV-NP antigen, mainly in the cytoplasm of astrocytes and neurons. Results of this work contribute to the opinion that red foxes act as a potential reservoir of CDV and underline the importance of routine vaccination of dogs that could come in close contact with these animals. Potential active surveillance program would give a better insight in the degree of CDV infection in wildlife.
Influence of High Frequency Electromagnetic Fields Produced by Antennas for Mobile Communication on the Structure of the Pancreas in Rats: Histological and Unbiased Stereological Analysis
Authors: Paraš D.Smiljana , Gajanin B. Radoslav , Manojlović Lj. Maja , Ružić Nj. Zoran
Published: January 2019

The emission of high frequency electromagnetic fields (HF EMF) produced by antennas for mobile communications has been controversially alleged to have adverse health effects. The aim of our work was to examine whether there are effects on living organisms from HF EMF produced by mobile communication antennas. In this experiment Wistar strain rats were exposed to HF EMF with the following characteristics: 1.9 GHz frequency, 0.24 A/m intensity, electric field strength of 4.79 V/m, and SAR (specific absorption rate) value of 2.0 W/m2. Exposure time was 7 hours per day, 5 days per week, over the course of sixty days. This experiment was conducted on a total of 30 male rats divided randomly into two equal groups: one group of animals was exposed to GSM fields (Global System of antennas for Mobile Communications) as described above whereas the other group of animals was not exposed to any GSM fields. In our study, results show that the quantity, diameter and numerical density of the islets of Langerhans in the pancreatic tissue increased in rats exposed to HF EMF compared to the unexposed group. The volume density, number and numerical density of pancreatic cells also changed in rats that were exposed to the HF EMF compared to the unexposed group. Our study shows a change in the stereological and histological parameters of rat pancreatic tissue due to the effects of HF EM fields produced by antennas for mobile communication.
Effect of Flax-Seed Enriched Concentrate Supplementation in Grazing Pramenka Breed Lamb’s Diet on Omental Fat Fatty Acids
Authors: Mujić Emir , Omanović Halil , Mateo Javier , Pračić Nermin , Vilić Husein , Šahinović Refik , Nedić Drago , Giráldez Francisco Javier , Lorenzo Jose Manuel , Červek Matjaž
Published: January 2019

This research is aimed at determining the impact of supplementing extensively reared lambs with a limited amount of flax seed enriched-concentrate on the fatty acid profile of the lamb meat (omental fat depot). A total of 96 60-day old Pramenka breed lambs (23.85±3.98 kg live body weight; 60±10 days of age; 42 males and 54 females) raised on pasture with their dams were randomly divided in three experimental groups: control (CON) or extensive rearing group, which did not receive any supplementary feed; concentrate (CC) group, receiving 300 g of a conventional commercial concentrate feed per animal daily, and concentrate-flax seed (CC-FS) group, receiving 300 g/day of the concentrate supplemented with 5% of flax seed. After 60 days of experimental period, 10 lambs were selected (5 males and 5 females) from each group and slaughtered. Omental fat samples were taken and analyzed to determine their fatty acid profile. Significant (P>0.05) differences in the fatty acid profile between CON and CC groups were small. However, enrichment of the concentrate with 5% flax seed increased the percentages of PUFA and n-3 PUFA when compared to both CON and CC groups and thus slightly improved the nutritional characteristics of the omental fat. The effect of sex on the fatty acid profile was only observed for C20:4 n-6 and C20:5 n-3 (P < 0.05).
Eating Behaviour and Food Preferences of Tîrgu Mures High School Students
Authors: Salcudean Maria , Rus Victoria , Ruta Florina , Dogar Catalin Moise , Simion Iustinian , Nemes Levente
Published: January 2019

Introduction. Due to a busy and exhausting urban lifestyle parents do not always have the necessary time to pay sufficient attention to the quality of the dietary habits of their children.

Objective. Starting from the premise that teenagers have insufficient information about healthy eating, the present study aimed to highlight eating behaviours and nutrition knowledge deficits in a group of 427 high school students from Tîrgu Mures.

Methods. An observational study based on lifestyle and food frequency consumption was conducted. In 2017, students in fifteen classes from several High School Institutions from Targu Mures, Romania, were asked to complete a questionnaire with questions relating to the current state of health, lifestyle characteristics, anthropometric indicators, frequency of daily meal consumption, significance and intake of food additives, leisure activities performed and also teenagers’ preferences for food products.

Results. The average age of the respondents was 16.1 years old, 72.6% were boys, and 82% lived in the city. 43.6% of respondents stated that food is a necessity, while 22% asserted that food characterizes a pleasure for them. Concerning the calorific value of foods, 32.8% stated that they have no interest in the calorie content of different food products while only 26%, mainly girls, took notice of these. 31.10% of respondents indicated that they include the recommended amount of vegetables in their daily diet, 22% prefer to eat preserved foods while increased consumption of sweets was observed in 39.80%. 55.50% of respondents ate breakfast on a regular basis, and 37% read food labels.

Conclusions. The results emphasise the necessity to develop more effective educational programs designed to create necessary background information for a young generation, change adolescent dietary behaviours for the better, and thus prevent dietary related diseases.
Effect of Food on the Pharmacokinetics of Gliclazide 60 mg Modified Release Tablet in Healthy Caucasian Volunteers
Authors: Pop Diana , Gheldiu Ana-Maria , Oroian Monica , Marcovici Adriana , Bhardwaj Sandeep , Khuroo Arshad , Kochhar Ravi , Vlase Laurian
Published: January 2019

Objective: To evaluate the food effect on glicazide disposition in clinical trials conducted on healthy Caucasian volunteers who were given a new modified release oral formulation of Gliclazide 60 mg developed by Sun Pharmaceutical Industries, India.

Methods: The studies were designed as open-label, randomized, single-dose, crossover studies that consisted of two periods. During each study, venous blood samples were taken before and after drug administration up to 96 hours. Subsequently, individual plasma profiles were determined and non-compartmental method was employed for the assessment of food effect on the pharmacokinetic profile of gliclazide. The statistical significance of differences for the main pharmacokinetic parameters was evaluated by ANOVA test, for p < 0.05 statistical significance was decided. The relative profiles of absorption of gliclazide were obtained by mathematical deconvolution. All calculation were performed by Phoenix WinNonlin®.

Results: High-fat, high-calorie meal decreased gliclazide exposure. The mean maximum plasma concentration decreased with 14%, while the mean total area under the plasma concentration-time profile registered a 17% decrease. The elimination half-lives under fasted and fed conditions were comparable and the time to maximum plasma concentration was shortened under fed condition. Safety evaluation showed that overall gliclazide was well tolerated under both fasted and fed condition.

Conclusions: The statistical analysis revealed the lack of food effect on the new modified release tablets of Gliclazide 60 mg. However, before stating a definite conclusion regarding the food effect on gliclazide pharmacokinetic profile, additional studies on patients with type 2 diabetes mellitus should be conducted.
Sampling k-partite graphs with a given degree sequence
Authors: Kayibi Koko K. , Samee U. , Pirzada Shariefuddin , Khan Muhammad Ali
Published: January 2019

The authors in the paper [15] presented an algorithm that generates uniformly all the bipartite realizations and the other algorithm that generates uniformly all the simple bipartite realizations whenever A is a bipartite degree sequence of a simple graph. The running time of both algorithms is 𝒪(m),where

m
=

1
2

∑

i
=
1

n

a

i

${\rm{m}} = {1 \over 2}\sum\nolimits_{\rm {i} = 1}^n {{ \rm{a}_\rm {i}}}$

. Let A =(A1 : A2 : ... : Ak) be a k-partite degree sequence of a simple graph, where Ai has ni entries such that ∑ni=n. In the present article, we give a generalized algorithm that generates uniformly all the k-partite realizations of A and another algorithm that generates uniformly all the simple k-partite realizations of A. The running time of both algorithms is 𝒪(m), where

m
=

1
2

∑

i
=
1

n

a

i

$m = {1 \over 2}\sum\nolimits_{i = 1}^n {{a_i}}$

.
Statistical complexity of the quasiperiodical damped systems
Authors: Fülöp Ágnes
Published: January 2019

We consider the concept of statistical complexity to write the quasiperiodical damped systems applying the snapshot attractors. This allows us to understand the behaviour of these dynamical systems by the probability distribution of the time series making a difference between the regular, random and structural complexity on finite measurements. We interpreted the statistical complexity on snapshot attractor and determined it on the quasiperiodical forced pendulum.
Realization of a Long-haul Optical Link with Erbium Doped Fiber Amplifier
Authors: Huszaník Tomáš , Turán Ján , Ovseník Ľuboš
Published: January 2019

The need for high capacity and bandwidth in broadband communication systems increased rapidly in a few past years. Optical fiber is now the major transmission medium for fast and reliable communication replacing the old copper-based connections. However, with the deployment of optical networks, number of problems arise. The main problem of optical networks is the amplification in the long-distance transmission. Erbium doped fiber amplifier (EDFA) is the leading technology in the field of optical amplifiers. It uses erbium doped fiber to amplify optical signal. The importance of amplification in optical domain is relevant in long-haul and high-speed transmission systems. In this paper the study of the EDFA is presented. Based on an analytical study, the simulation model of the EDFA is created. The main aim is to determine the optimal parameters of the EDFA for a long-haul 16-channel DWDM (Dense Wavelength Division Multiplexing) system. The performance of the proposed DWDM system is mathematically analyzed using BER (Bit Error Rate) and Q factor.
Effects of Dietary Moringa oleifera Leaf Meal as a Replacement for Soybean Meal on Growth, Body Composition and Health Status in Cyprinus carpio Juveniles
Authors: Adeshina Ibrahim , Sani Ramatu Abdulkareem , Adewale Yusuf Adetunji , Tiamiyu Lateef Oloyede , Umma Samuel Bem
Published: January 2019

The growth performance, nutrient utilization and health status of Cyprinus carpio fed various levels of Moringa oleifera leaf meal as a replacement for soybean meal was investigated. Six isonitrogenous diets were formulated with Moringa oleifera leaf meal at 0%, 10%, 20%, 30%, 40% or 50% crude protein replacement. The diets were fed to the fish at 5% body weight to 360 Cyprinus carpio juveniles (8.12±0.21 g) allotted to 18 happas (1 m3) in a completely randomized design for 12 weeks. The results revealed that crude protein replacement levels of 30% had significantly better final weight, weight gain, specific growth rate, protein efficiency ratio and feed conversion ratio, while survival rates were not significantly different. Also, haematological, biochemical and immune responses of the fish fed Moringa oleifera leaf meal fortified diets were significantly improved. The results further suggest that higher inclusion replacement is possible but opined that, for growth and economic consideration, Moringa oleifera leaf meal could be used to replace 30% crude protein of soybean in the diet of Cyprinus carpio juveniles.
A sequence adapted from the movement of the center of mass of two planets in solar system
Authors: Fialová Jana
Published: January 2019

In this paper we derive a sequence from a movement of center of mass of arbitrary two planets in some solar system, where the planets circle on concentric circles in a same plane. A trajectory of center of mass of the planets is discussed. A sequence of points on the trajectory is chosen. Distances of the points to the origin are calculated and a distribution function of a sequence of the distances is found.
New stability results for spheres and Wulff shapes
Authors: Roth Julien
Published: January 2019

We prove that a closed convex hypersurface of the Euclidean space with almost constant anisotropic first and second mean curvatures in the Lp
-sense is W
2

,p
-close (up to rescaling and translations) to the Wulff shape. We also obtain characterizations of geodesic hyperspheres of space forms improving those of [10] and [11].
Death, ethical judgments and dignity
Authors: Komenská Katarína
Published: January 2019

In Peter Singer’s article “The Challenge of Brain Death for the Sanctity of Life Ethic”, he articulates that ethics has always played an important role in defining death. He claims that the demand for redefining death spreads rather from new ethical challenges than from a new, scientifically improved understanding of the nature of death. As thorough as his plea for dismissal of the brain-death definition is, he does not avoid the depiction of the complementary relationship between science and ethics. Quite the opposite, he tends to formulate a stronger, philosophically more consistent argument to help science and medical practitioners to define life, death, and the quality of life. In my commentary, I would like to focus on two issues presented in Singer’s study. Firstly, I will critically analyze the relationship between science and ethics. Secondly, I will follow on from Singer’s arguments differentiating between end of life as an organism and end of life as a person. The latter case is necessarily linked with man’s participation in her/his life, setting life goals, and fulfilling her/his idea of good life. Through the consequential definition of the dignity in ethics of social consequences, I will try to support Singer’s idea.
Axiology and the mortality of the human being
Authors: Wojewoda Mariusz
Published: January 2019

Awareness of mortality is one of the key aspects of human existence. Death goes beyond the boundary of knowledge, mortality. However, it is actually experienced by man as something inevitable. Death is a fact – the end of life, and the experience of mortality is one of the borderline situations. In the essay, the author puts forward the thesis that the experience of mortality has a significant impact on the human understanding of values. Attitudes towards death be it fear, resignation, indifference, fascination, mourning, sadness, despair after the loss of a loved one, or the desire for death, indicate the wealth of the world of value of axiological experience. The attitude of the person towards death, in some sense, is a test of our humanity, the principal value to which we refer most often. The author of the essay adopts the position of axiological relationalism (or axiological structurism), it implies that values are independent of the subject, they form a network of relational connections, but they are in a significant way connected with culture. The study of these connections: 1) with the world of people, 2) world of things, 3) internal relations that take place between values, allows us to get to know the complex structure of the world of values. In the article, the author analyzes in what sense mortality influences human understanding of values.
Lost and Wasted Human Capital – How Transformations of Family, Socialization, and Population Control Influence Welfare and Well-Being
Authors: Michalski Michał A.
Published: January 2019

This paper analyzes the influence of the transformations of marriage and family on the human capital (HC) creation in contemporary Western societies. One of the basic assumptions included here is that these processes are connected with profound socio-cultural shifts that were initiated in the 20th century, and were manifested e.g. through the sexual revolution of the 1968.

According to the thesis of the paper, it is necessary to point at this complex and multidimensional changes to understand why and how the West is losing its HC, which is followed by decrease in well-being and welfare at the same time. This important and alarming problem is illustrated by the analysis of the impact of abortion on the U.S. society and economy.

The paper contributes in an innovative way to the research on the quality and quantity of HC, which becomes a more and more valued factor of socio-economic development.

The analyses undertaken here engage the contribution of research on HC and family from such disciplines as economics, sociology, psychology, and cultural studies.
Mycobiota and Mycotoxic Contamination of Feed Cereals
Authors: Harčárová M. , Čonková E. , Sihelská Z.
Published: January 2019

The cereals are a suitable substrate for the growth of microscopic filamentous fungi. Micromycetes are capable of reducing the nutritional value of feedstuff and they can produce several mycotoxins. The most frequent genera of microscopic filamentous fungi are Fusarium, Penicillium, Alternaria and Aspergillus. The contamination by microscopic fungi and mycotoxins was determinated in 56 samples of feed cereals originating from the Slovak Republic. The most common genera of fungi detected in the feed cereals included: Alternaria (67.8 %), Fusarium (44.6 %), Penicillium (39.2 %), Mucor (30.3 %), Rhizopus (28.5 %), Cladosporium (21.4 %), Scopulariopsis (8.9 %) and Aspergillus (1.7 %). Deoxynivalenol was present in 24 samples (42.8 %) and zearalenone in 15 samples (26.7 %). The values of both mycotoxins did not reach the regulatory limits and thus they do not pose a risk to livestock nutrition.
The Smart City is landing! On the geography of policy mobility
Authors: Hýllová Lucia , Slach Ondřej
Published: January 2019

The aim of this paper is to provide a geographical urban policy perspective on the strategy of Smart Cities in the specific context of Czechia. Considering that the implementation of the Smart Cities (SC) concept is still relatively young in Czechia, it is highly relevant to examine the time-space diffusion of this concept in Czechia in the geographical lens: where the first initiative to build a smart city started, when the process was started and by whom; in other words, to provide basic empirical evidence of understanding the policy mobility and implementation of smart city policy into the urban development strategies. In the first of our approach, we evaluate the implementation of the term “smart city” in strategic city documents. The next step is the analysis of the strategic urban (city) and smart city documents by distinguishing conceptually distinct pillars of the SC concept and an overview of actors and policy-makers who initiate and support individual pillars of the concept of SC in Czechia. The results of the analysis highlight the differences between the implemented SC topics into city strategies which are caused by fragmented policy mobility, its modifications and influence of key actors who have found the opportunity to participate in policy-making processes at the certain spatial level.
Generalized Knockout Tournament Seedings
Authors: Karpov A.
Published: January 2019

Generalized knockout tournament seedings for an arbitrary number of participants in one match are designed. Several properties of knockout tournament seedings are investigated. Enumeration results for knockout tournament seedings with different properties are obtained. Several new generalized knockout tournaments seedings are proposed and justified by a set of properties.
Assessment of Anemia in Correlation with Inflammatory Status in Patients with Intestinal Transit Disorders
Authors: Voicu Cristina , Rugină Sorin
Published: January 2019

The intestinal transit disorders are polymorphic clinical manifestations requiring complex differential diagnosis and a multidisciplinary medical team.

A major challenge for the clinician is the differentiation of patients with organic suffering versus functional disorder.

Anemia is the most common extra-digestive manifestation of intestinal inflammatory diseases.

We have evaluated biologically and by imaging patients with diarrhea and alternating diarrhea/constipation without including infectious causes. We plan to determine in these patients the status and type of anemia, as well as its correlation with local and systemic inflammation.
Relationship of Lichen Planus, Hepatitis Virus C and Low Level of Total Antioxidant Capacity
Authors: Georgescu Simona Roxana , Musetescu Alina , Ene Corina Daniela , Ene Cosmin , Mitran Mădălina , Mitran Cristina , Tampa Mircea , Nicolae Ilinca
Published: January 2019

Based on the latest medical research, it is supposed that lichen planus is an inflammatory disorder, associated with autoimmune diseases, hepatitis C infection, oxidative stress or antioxidant deficiency. The purpose of the present work is to determine a panel of serum antioxidants, possibly involved in the development/persistence of the disease. The determination of extracellular antioxidants (bilirubin, uric acid, albumin, iron, transferrin, ferritin, copper, ceruloplasmin, total antioxidant capacity) in patients with lichen planus during exacerbations have revealed a significant reduction in non-enzymatic antioxidant systems. Hepatitis C virus enhances the deficit of antioxidants in patients with lichen planus. Based on these findings, the authors consider that lichen planus is a complex disease of unidentified cause and its pathogenic mechanisms are still incompletely elucidated. It may be speculated that several interconnected mechanisms are involved in the onset and evolution of lichen planus.
Development of C-Means Clustering Based Adaptive Fuzzy Controller for a Flapping Wing Micro Air Vehicle
Authors: Ferdaus Md Meftahul , Anavatti Sreenatha G. , Garratt Matthew A. , Pratama Mahardhika
Published: January 2019

Advanced and accurate modelling of a Flapping Wing Micro Air Vehicle (FW MAV) and its control is one of the recent research topics related to the field of autonomous MAVs. Some desiring features of the FW MAV are quick flight, vertical take-off and landing, hovering, and fast turn, and enhanced manoeuvrability contrasted with similar-sized fixed and rotary wing MAVs. Inspired by the FW MAV’s advanced features, a four-wing Nature-inspired (NI) FW MAV is modelled and controlled in this work. The Fuzzy C-Means (FCM) clustering algorithm is utilized to construct the data-driven NIFW MAV model. Being model free, it does not depend on the system dynamics and can incorporate various uncertainties like sensor error, wind gust etc. Furthermore, a Takagi-Sugeno (T-S) fuzzy structure based adaptive fuzzy controller is proposed. The proposed adaptive controller can tune its antecedent and consequent parameters using FCM clustering technique. This controller is employed to control the altitude of the NIFW MAV, and compared with a standalone Proportional Integral Derivative (PID) controller, and a Sliding Mode Control (SMC) theory based advanced controller. Parameter adaptation of the proposed controller helps to outperform it static PID counterpart. Performance of our controller is also comparable with its advanced and complex counterpart namely SMC-Fuzzy controller.
A Framework for Multidisciplinary Business Simulations
Authors: Busbach-Richard Uwe , Dietrich Antje
Published: January 2019

In this paper, the design and introduction of a framework for multidisciplinary business simulations at the School of Public Administration of Kehl University will be presented. Within Kehl’s Public Administration study program, various subjects like organization, law, human resources, computer sciences, finance, psychology and economics are supported in an interdisciplinary way. Both theoretical and scientific skills as well as soft skills such as teamwork, project management and coordination will be further developed by using an interdisciplinary approach. A framework for multidisciplinary business simulations has been developed to support this interdisciplinary approach. The framework integrates realistic and practical simulations of interdisciplinary case studies into the study program of Public administration at Kehl University. In order to reduce costs for case study development, the framework offers a generic case study pattern. This pattern was purposefully developed and covers very different disciplines in the best possible way so that the students can conduct simulations that are realistic and possible during their studies. Further, two different simulation implementations of the case studies were designed within the framework for multidisciplinary business simulations. A short-term simulation intends to check the ongoing learning success. A long-term simulation aims for giving students feedback concerning their skills just before graduating. The case studies based on the generic case study pattern come from a wide variety of public administration tasks. Examples of currently conceived case studies include e-invoicing, IT-infrastructure for schools and IT-office workplaces. The case studies were developed together with practitioners from municipalities and local agencies in order to create realistic simulations. This addresses the actual complexity of the future working environment of students. The comprehensive application of knowledge learnt in different subjects motivates students to work on these case studies.
Relationships between grain size in self-developed soft magnetic composites and the Grucad hysteresis model
Authors: Jastrzȩbski Radosław , Jakubas Adam , Chwastek Krzysztof
Published: January 2019

Soft magnetic composites (SMCs) have been in the spotlight of magnetic community due to their unique properties which can easily be tailored up to a specific application. The present paper is focused on the possibility to develop SMC cores produced from iron powder mixed with suspense polyvinyl chloride. Important processing parameters like grain size are correlated with the parameters of a simple phenomenological hysteresis model developed by the Grucad research group.
Research of magnetic properties of spolic technosols (alcalic/hyperartefactic) on the landfill of industrial waste from nickel production
Authors: Reiffers Marián , Vilček Jozef , Michaeli Eva , Čurlík Ivan , Klamár Radoslav , Čech Vladimír , Ivanová Monika , Koco Štefan , Pasternák Tomáš , Il’kovič Sergej , Parma Ludvík , Šebeň Vladimír , Šterbáková Katarína , Litecká Juliána , Csatáryová Mária , Zapotoková Mariana , Solar Vladimír
Published: January 2019

The article presents the results of measurements of magnetic properties of samples spolic technosols (alcalic/hyperartefactic) form the landfill of black nickel mud at Sered’, Slovakia. We measured the dependence of magnetic moment as a function of temperatures (240-340 K) and applied magnetic fields up to 7.2 MA/m (90 kOe). We observed at room temperature the tendency to saturation of magnetic moment. The temperature dependences showed possible ferromagnetic behaviour.
Fatty acid profile in fat obtained from edible part of land snails harvested in Poland
Authors: Szkucik Krzysztof , Ziomek Monika , Paszkiewicz Waldemar , Drozd Łukasz , Gondek Michał , Knysz Przemysław
Published: January 2019

Introduction: The objective was to determine the content of fatty acids in edible snail fat by snail species, collection site, and processing stage.

Material and Methods: The research material comprised 180 edible fat samples from the three genera of edible snails collected in Poland: free-living Helix pomatia (HP) and two cultivated Cornu subspecies: C. aspersa maxima (CAM) and C. aspersum aspersum (CAA). All snails came from the Greater Poland and Lower Silesian Provinces: HP from their natural habitat and CAM and CAA from heliciculture farms. The studies focused on the raw meat, cooked meat, and frozen meat processing stages. Fatty acid (FA) profiles were determined by the gas chromatography method.

Results:
Helix pomatia fat showed a higher saturated fatty acid (SFA) content, whereas the fat of Cornu genus snails had a higher unsaturated fatty acid (UFA) component, i.e. monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA). Thermal processing of snail meat increased all the determined SFA and decreased all the PUFA values, and increased the content of C18:1, C20:1, and C22:1 acids in the MUFA group. The material collection site had limited impact on FA content as differences were noted only in levels of C18:1, C18:2 n6, and C20:5. The differences pertained only to the fat of farmed snails of the Cornu genus.

Conclusion: Due to the high content of UFA and a favourable ratio of n6:n3 acids and PUFA:SFA, snail fat can be regarded as nutritionally valuable.
Alkali-silica Reaction in Finnish Concrete Structures
Authors: Lahdensivu Jukka , Kekäläinen Pirkko , Lahdensivu Alina
Published: January 2019

Even though natural phenomena do not abide to borders, Finland has traditionally been considered an alkali-silica reaction (ASR) free country. This is due to exceptional quality of the mostly course crystalline igneous rocks. However, during the last few years dozens of cases of ASR have been reported. The scope of this study was to study the occurrence of ASR, and to find out the initiation time of the reaction in resent investigations of Finnish concrete structures. ASR is found occurring all over Finland. The reacting aggregates consist of rock types, which are considered relatively stable or low reacting in literature.
Rice Husk Resource for Energy and Cementitious Products with Low CO2 Contributions
Authors: During Otto , Bhochhibhoya Silu , Maskey Ramesh Kumar , Joshi Rajendra
Published: January 2019

Rice Husk Ash (RHA) is a well-known supplementary cementitious materials (SCMs) that can be used for concrete with reduced CO2 contributions. In 2016, only Nepal produced 5.2 million tonnes rice that gave about 1.14 million tonnes rice husk. The rice husk can also be used directly in a cement kiln as a fuel. This study analysis the potential CO2 reductions from three scenarios and emphasis strengths, weaknesses, opportunities and treats in the production systems for initiate a decision process with possibilities to get an industry project financed from the green climate found. The highest CO2 benefits were from rice husk used in a cement kiln were half of the yearly rice husk production in Nepal could reduce the climate impact with 808000 tonnes CO2.
Nutritional Assessment of Dialysis Patient with a Web-Based Tool Allows More Accurate Treatment of Malnutrition
Authors: Ferlinc Mihela , Knap Bojan
Published: January 2019

Background/Aims: Regular assessment of nutritional status of dialysis patients is vital for preventing malnutrition and protein energy wasting. The aim of this clinical study was to analyze dietary intake of dialysis patients and to determine if it meets their nutritional needs.

Methods: Clinical study was conducted on 30 randomly selected dialysis patients in the dialysis department of the University Medical Centre Ljubljana. Nutritional interview was conducted unannounced five times over a period of three months with the 24-hour recall method. Results were analyzed with Prodi 6.6 Expert software. Body composition was measured with bioimpedance spectroscopy.

Results: Average caloric intake of 30 patients is 14.1 ± 4.7 kcal/kg body weight per day, average protein intake is 0.61 ± 0.19 g/kg body weight per day. The average BMI (body mass index) is 27.9 ± 4.4 kg/m2, the average LTI (lean tissue index) is 12.5 ± 3.1 kg/m2, the average FTI (fat tissue index) is 14.2 ± 5.7 kg/m2 and the average phase angle is 4.2 ± 1.0. Average calorie intake and protein intake are inadequate according to the dietary recommendations for dialysis patients. Anthropometric measurements indicate sarcopenic obesity.

Conclusion: According to the aim of the study, we confirmed that caloric and protein intake of dialysis patients were inadequate according to their needs. Depending on the results of nutritional analysis and bioimpedance measurements, we have confirmed the presence of protein energy wasting among observed patients.
Hyperfibrinogenemia in Peripheral Arterial Disease: Coexistent and Independent Risk Factor (A Report of Two Cases and Review of Literature)
Authors: Bosevski Marijan , Krstevski Gorjan , Mitevska Irena , Antova Emilija , Bosevska Golubinka
Published: January 2019

These case reports aim to show that hyperfibrinogenemia is a risk factor for the progression and prognosis of peripheral arterial disease (PAD), in patients with and without diabetes mellitus type 2.

We present a patient with PAD who has type 2 diabetes mellitus, who has previously been repeatedly treated for lower limb ischemia with multiple vascular surgeries performed. A few weeks before admission the patient developed critical lower limb ischemia, which was treated with an iliaco-popliteal and femorofemoral bypass. The patient had elevated serum fibrinogen values. In the current admission, renewed left limb ischemia was diagnosed, and surgically evaluated with a recommendation for amputation of the left limb as a surgical recommendation. Our second patient had a stable intermittent claudication, dyslipidemia and hyperfibrinogenemia. He was successfully treated for those risk factors. Regular monitoring of the patient showed improved claudication distance and quality of life

Our case reports, supported by a literature review, demonstrate that hyperfibrinogenemia is a possible risk factor for progression and the prognosis of PAD.
Evaluation of Correlation Between the Pharmacogenetic Profiles of Risperidone Treated Psychiatry Patients with Plasma and Urine Concentration of Risperidone and its Active Moiety 9-OH Risperidone Determined with Optimized Bioanalytical LC Method
Authors: Filipce Ana , Naumovska Zorica , Nestorovska Aleksandra Kapedanovska , Sterjev Zoran , Brezovska Katerina , Tonic-Ribarska Jasmina , Grozdanova Aleksandra , Suturkova Ljubica , Raleva Marija
Published: January 2019

Atypical antipsychotic risperidone is widely used first-line monotherapy in schizophrenia and combined therapy in bipolar disorders. Therapeutic plasma concentrations of risperidone and its active moiety are directly influenced by genetic variations in metabolic CYP450 enzymes (CYP2D6 and CYP3A4/5) and transporter (ABCB1) protein and additional environmental factors. Since active metabolite 9-OH risperidone has a greater percentage of the pharmacologically active fraction and is equipotent to the parent drug risperidone, it is assumed that it contributes significantly to therapeutic and adverse effects.

Unpredictable dose/concentration ratio, narrow therapeutic index, number of interactions, along with serious adverse reactions (ADR), raises the need for individualization of risperidone treatment and establishing of good therapeutic regime using TDM.

A simple and reliable validated bioanalytical liquide-liquide extraction HPLC/UV method was applied for the simultaneous determination of risperidone and its active metabolite, 9-OH risperidone, in human plasma and urine of 52 hospitalized schizophrenia/bipolar disorder patients treated with risperidone as monotherapy and in polytherapy. All the patients were previously genotyped for CYP2D6 (EM=30, EM/IM=14, IM=4 IM/PM=1 and PM=3) and ABCB1 using Real-Time PCR methods with TaqMan SNP genotyping suitable assays according to the guidelines of the manufacturer (Life Technologies, USA).The influence of CYP2D6 phenotype on metabolic ratio MR (Ris/9-OHRis) in plasma (p=0.012) and in urine (p=0.048) was confirmed. Statistically significant correlation (R2=55.53%, Rho=0.844, p<0,0001) for MR in both plasma and urine indicates that urine may be utilized as appropriate media for initial CYP2D6 phenotype identification and selection of patients on risperidone treatment with high risk for ADR.
Evaluation of Pain Following the Use of Scalpel Versus Electrosurgery for Skin Incisions in the Facial Regions
Authors: Peneva Margarita , Gjorgjeska Andrijana , Gjorgova Smilja Tudzarova , Dzonov Boro , Noveski Lazo , Ginoski Vladimir , Tolevska Roza Dzoleva , Breshkovska Hristina
Published: January 2019

Introduction: Postoperative pain presents a significant medical problem. It can create a considerable discomfort in the immediate postoperative period and thus increase patient’s morbidity. Multiple mechanisms are involved in its’ etiology, one of them being the method of tissue incision. The aim of this study is to compare the early postoperative pain following incision with two different methods, scalpel and electrosurgery in the facial regions.

Material and methods: Eighty patients with both benign and malignant skin lesions in the facial regions undergoing surgery were enrolled in this study. Patients were randomized in two groups. In group A, comprising 40 patients, cold steel surgical scalpel №15 was used for the surgical procedure. Electrosurgical microneedle with 0.06mm tip radius and generator unit KLS Martin Electrosurgical Unit ME MB 2 set on cutting mode, power 12 W was used for performing the surgery in group B including the same number of patients. After the surgery patients were given analgesics on their demand. The total number of on demand analgesics requirements was calculated. The patients were also asked to note the oral analgesics they were taking after being released from the hospital.

Results: Results of this study showed a statistically significant difference between the groups in the analgesics demand on the day of the operation (p=0.041). On the day of the operation 52.5% patients in the scalpel group and only 30% of the patents of the electrosurgery group received analgesics on demand. In all other analysed time points, the patients in the scalpel group received analgesics more often than the patients in the microneedle group, but with no statistically confirmed difference between the groups (p>0.05). Even more significant is the fact that patients treated with electrosurgery that needed analgesics, had significantly bigger excision area median 471 (rank 283-589) compared to the patients treated with the conventional method 289 (rank 177-432) (p=0.016).

Conclusion: In accordance with previous studies our results suggested a significantly reduced postoperative pain in the electrosurgery group.
A 4-Year-Old Boy with Beckwith Wiedemann Syndrome (BWS)
Authors: Janchevska Aleksandra , Tasic Velibor , Laban Nevenka , Polenakovic Momir , Gucev Zoran , Bachmann Nadine , Bergmann Carsten
Published: January 2019

Objectives: Molecular characterization of a patient with BWS.

Clinical presentation and intervention: A 4-year-old boy with overgrowth (weight above 99th and height at 99th percentile) had longitudinal hemihypertrophy of the tongue and left cheek. In addition, there was a difference of one centimeter in the circumference of the left and right leg. Molecular genetic analysis revealed hypomethylation of KvDRM1 (LIT1) in the imprinting control region-2 (ICR2) on chromosome 11p15.5 and a normal methylation pattern of the H19-differentially methylated region (H19-DMR) in the ICR1. The estimated tumor risk was 1-5%.

Conclusion: This patient with clinical characteristics of BWS has an imprinting defect associated with a low risk of embryonal tumors.