bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of highly active and robust Cu-Co–rGO electro-catalytic electrode for OER
Authors: Aiswarya P , Manu R.
Published: July 2024

In the present work a facile method was adopted for the fabrication of highly active and dimensionally stable cobalt-reduced graphene oxide (rGO) based composite electrode for OER process. The metal loading and the amount of graphene was optimized for better performance of the electrode. The development of these type of electrodes is noteworthy taking the advantage of the method and the materials used. The morphology and the composition were analyzed through scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX) and X-ray photo electron spectroscopy (XPS). Spectroscopic characterization was done using Fourier transform infrared (FTIR) analysis. Electrochemical characterization revealed excellent electro-catalytic activity of the prepared electrode and strongly suggest synergistic reaction between Co3O4 and rGO. The developed electrode can realize excellent Oxygen Evolution Reaction (OER) activity in alkaline media with low over potential and low tafel slope with long-term stability as evidenced from various analysis.
Thematic Analysis and Sentiment Evolution of Online Public Opinion on Hangzhou Asian Games: The Case of Sina Weibo
Authors: Che Wen , Gao Mingze , Qi Shenghua
Published: July 2024

It is of great significance to study the emotional evolution characteristics of significant sports events, to understand and master the changing law of online public opinion topics, to increase the attention and influence of sports events, to promote the dissemination of sports culture, and to correctly guide the direction of online public opinion on sports events. By dividing the life cycle of "Hangzhou Asian Games" microblog topics, using the LDA topic model and SnowNLP sentiment analysis, we mined the topics of online public opinion, analyzed the characteristics of public sentiment, and portrayed the sentiment evolution of "Hangzhou Asian Games" microblog topics in three dimensions: time, space and gender. The results show that Sina Weibo users are mainly optimistic about the topic of "Hangzhou Asian Games." The economically developed provinces in the southern and eastern regions are more optimistic about the topic than the economically less developed provinces in the western and northeastern regions, with higher user participation. In each life cycle, the emotional focus and emotional tendency show positive emotion>neutral emotion>negative emotion, and there are differences in the public opinion attention and emotional state of different topics in different periods, regions, and genders. Compared with other public opinion events, the emotional change of sports events public opinion is distinctive and unique, and its emotional evolution process is closely related to the development of different themes at different phases of sports events.
Analysis of Leaf cover on Raspberry Fruits Based on Hyperspectral Techniques Combined with Machine Learning Models
Authors: Chen Zhujun , Wang Juan , Xi Ruiqian , Ren Zhenhui
Published: July 2024

The aim of this study is to explore the potential application of hyperspectral technology in detecting the problem of fruit cover in the orchard. Three types of hyperspectral data were collected using a hyperspectral instrument to cover raspberry fruits with leaves. Machine learning models were used to classify and regress covered and uncovered fruits. The results show that hyperspectral technology can effectively differentiate fruits under different cover conditions, with spectral intensity data performing better in addressing cover issues. Random forest (RF) and multilayer perceptron (MLP) models demonstrated high accuracy in classification analysis, with MLP achieving a ROC AUC value of 0.99 on full-band data. Regression analysis also revealed a significant correlation between degree of coverage and spectral features, highlighting in particular the high explanatory power of light intensity data in predicting degree of coverage. This study not only confirms the application value of hyperspectral technology in precision agriculture, but also provides new technical support for intelligent orchard management and automated harvesting. Future research will focus on improving the generalisation ability of the models, integrating multi-source data to further improve the accuracy of coverage detection, and exploring the development of real-time monitoring and automatic control systems to achieve comprehensive intelligence in orchard management.
Attention-enabled Multi-layer Subword Joint Learning for Chinese Word Embedding
Authors: Xue Pengpeng , Tan Liang , Xiong Jing , Liu Zhongzhu , Liu Kanglong
Published: July 2024

In recent years, Chinese word embeddings have attracted significant attention in the field of natural language processing (NLP). The complex structures and diverse influences of Chinese characters present distinct challenges for semantic representation. As a result, Chinese word embeddings are primarily investigated in conjunction with characters and their subcomponents. Previous research has demonstrated that word vectors frequently fail to capture the subtle semantics embedded within the complex structure of Chinese characters. Furthermore, they often neglect the varying contributions of subword information to semantics at different levels. To tackle these challenges, we present a weight-based word vector model that takes into account the internal structure of Chinese words at various levels. The model further categorizes the internal structure of Chinese words into six layers of subword information: words, characters, components, pinyin, strokes, and structures. The semantics of Chinese words can be derived by integrating the subword information from various layers. Moreover, the model considers the varying contributions of each subword layer to the semantics of Chinese words. It utilizes an attention mechanism to determine the weights between and within the subword layers, facilitating the comprehensive extraction of word semantics. The word-level subwords act as the attention mechanism query for subwords in other layers to learn semantic bias. Experimental results show that the proposed word vector model achieves enhancements in various evaluation metrics, such as word similarity, word analogy, text categorization, and case studies.
Study on the mechanism of KIF2C/PLK1 in the growth and metastasis of oral squamous cell carcinoma
Authors: Wang Chenfei , Su Yuyuan , Shi Jinlong , Feng Guijuan
Published: July 2024

Oral squamous cell carcinoma (OSCC) is a prevalent malignant tumor characterized by challenging early symptom detection, rapid growth, extensive infiltration, and frequent lymph node metastasis, resulting in a generally unfavorable prognosis. Given the heterogeneity and high metastatic potential of OSCC, there is a need for more effective therapeutic targets. This study aims to investigate the impact of kinesin family member 2C (KIF2C) and Polo-like protein kinase 1 (PLK1) on OSCC progression and their potential interaction. Through the utilization of immunohistochemistry and western blot experiments, it was determined that the expressions of KIF2C and PLK1 were significantly upregulated in human oral cancer tissues and OSCC cell lines (SCC9, SCC25, Cal27). Subsequently, an OSCC cell was selected for analysis based on the detection of KIF2C expression (qPCR, WB) in the OSCC cell line. Following transfection with KIF2C and PLK1 interference vectors, the proliferation, migration, and invasion of OSCC cells were assessed using the CCK-8 method, EdU proliferation experiment, wound closure method, and Transwell method. Flow cytometry (FCM) and western blot techniques were utilized to assess alterations in apoptosis, angiogenesis, and epithelial-mesenchymal transition (EMT) in OSCC cells. Our findings indicate that KIF2C influences the proliferation, invasion, and metastasis of oral cancer cells, suggesting a potential association between KIF2C and PLK1. Specifically, KIF2C was found to enhance EMT, matrix degradation, and angiogenesis in OSCC cells by up-regulating PLK1. Subsequent flow cytometry analysis revealed that KIF2C and PLK1 suppressed apoptosis in cancer cells and induced proliferation in the S phase, thereby promoting cell proliferation. The association between the expression levels of KIF2C and PLK1 and the development and advancement of OSCC was confirmed, suggesting their potential utility as diagnostic and prognostic markers for OSCC.
Discovery of the Widespread Site-Specific Single-Stranded Nuclease Family Ssn
Authors: Veyrier Frédéric , Chenal Martin , Rivera-Millot Alex , Harrisson Luke , Khairalla Ahmed , Nieves Cecilia , Bernet Eve , Esmaili Mansoor , Belkhir Manel , Perreault Jonathan
Published: July 2024

Site-specific endonucleases that exclusively cut single-stranded DNA have hitherto never been described and constitute a barrier to the development of ssDNA-based technologies. Here, we identify and characterize one such novel family of widely distributed site-specific single-stranded nucleases (Ssn) exhibiting unique ssDNA cleavage properties. This family is a member of the GIY-YIG nuclease superfamily that encompasses restriction enzymes, homing endonucleases, and transposases involved in important biological processes. Unlike other families of the GIY-YIG superfamily that typically possess additional functional domains that dictate their various specificities, Ssn are small proteins only consisting of the GIY-YIG domain. By first comprehensively studying the Ssn homolog from Neisseria meningitidis, we demonstrate that it interacts specifically with a sequence element (called NTS) present in hundreds of copies and surrounding important genes in pathogenic Neisseria. In this species, NTS/Ssn interactions modulate horizontal gene transfers through natural transformation and thus constitute a novel mechanism shaping genome dynamics. We further identified thousands of Ssn homologs throughout the bacterial kingdom and demonstrate, in vitro, a range of Ssn nuclease specificities for their corresponding NTS. We demonstrate proofs of concept for applications including ssDNA detection and digestion of ssDNA from Rolling Circle Amplification. This discovery and its applications set the stage for the development of innovative ssDNA-based molecular tools and technologies.
Identification of prognostic biomarkers for endometrioid endometrial carcinoma based on the miRNA and mRNA co‐expression network regulated by estradiol
Authors: Jin Li , Xie Qiu , Huang Junting , Xie Yuan
Published: July 2024

Background: Endometrioid endometrial carcinoma (EEC), an estradiol-related disease, remains a serious health threat to women because of its high incidence and trend of rejuvenation. Accumulating evidence has highlighted that microRNAs (miRNAs) and messenger RNAs (mRNAs) play important roles in various biological processes involved in the pathogenesis of EEC. This study aimed to identify the potential prognostic biomarkers associated with EEC regulated by estradiol.
Results: Four estradiol-related DEGs were associated with prognosis, and 235 overlapping target DEGs were screened and incorporated into the functional enrichment analysis and protein–protein interaction network visualization studies. Additionally, SACS and GPR157were identified as potential biomarkers for EEC prognosis through survival analyses. Furthermore, single-cell transcriptome data were analyzed to show changesin gene expression levels in specific cell types.
Conclusions: This study demonstrates that miR-142-5p–SACSand miR-30a-5p–GPR157, which are regulated by estradiol, may hold promise as diagnostic and prognostic biomarkers and novel therapeutic targets for EEC.
Predictors of Work-Related Violence Against Nurses Working at a Tertiary Hospital in Kisumu, Kenya.
Authors: Atogo Anne Owira , Nyaberi Zablon , Arudo John
Published: July 2024

Background Workplace violence (WPV) is any act in which a person is abused, threatened, intimidated or assaulted in their work environment. It could involve physical, verbal or written threatening behaviour or physical attacks. Workplace violence against nurses is increasingly becoming a major problem globally. Because of the nature of their work, nurses are at increased risk of workplace violence.Objective To assess workplace violence against nurses at Jaramogi Oginga Odinga Teaching and Referral Hospital.Materials and methods It employed a cross-sectional study design among 184 nurses randomly selected from Jaramogi Oginga Odinga Teaching and Referral Hospital in Kisumu-Kenya. Data was collected using a self-administered questionnaire that asked questions regarding their sociodemographic characteristics, nature of their work, experience with workplace violence and institutional factors that could be associated with workplace violence. The data obtained was analysed descriptively (in the form of frequencies and proportions for categorical variable and inferentially as mean with corresponding standard deviation) and inferentially. Pearson chi-square test was adopted to assess statistically significant association between predictors of WPV and violence occurrence. Odds ratios were computed at 95% confidence interval.Results This study enrolled 184 nurses with a mean age of 37 (± 9.5) years, of whom 62% were female. Majority (88%; n = 162) of the nurses enrolled were at the operational level with 2 (1.1%) being supervisors and 20 (10.9%) being in senior management. Workplace violence was reported by 70% of the respondents, with 41.8% of them saying they were verbally abused. Among those physically abused, 71.8% were assaulted by the relatives of the patients with 28.2% being injured because of the incident. Bullying by co-workers was noted among 24 (13.0%) of the respondents while 41 (22.3%) reported sexual harassment. 96.2% had not received any training on WPV prevention in the last twelve months. Working in the general surgery department (p < 0.001) and lack of safety measures (p = 0.020) predicted WPV.Conclusion the study reports that working in general surgical wards and lack of institutional measures against violence are the major predictors of workplace violence among nurses. There is need to understand institutional processes, procedures and operations that reduce the likelihood of workplace violence in other hospital departments and apply these findings to the general surgery unit where there was a higher prevalence of workplace violence.
PERAN DINAS EKONOMI KREATIF DAN UKM DALAM PEMBERDAYAAN UMKM PEREMPUAN DI KABUPATEN SLEMAN YOGYAKARTA
Authors: Nisa Kanita Khoirun , Wahyuni Titi , Budita Ayla Karina
Published: July 2024

Abstrak: Aplikasi ekonomi kreatif telah menjadi trendsetter di banyak negara di dunia. Konsep creative economy menjadi terobosan bisnis baru yang memadukan unsur kreativitas dan pembaruan dalam pembangunan ekonomi. Peneliti terdahulu telah banyak yang melakukan penelitian di sektor UMKM dengan memperhatikan fenomena sektor ekonomi kreatif, namun kajian mendalam tentang UMKM masih kurang. Kajian ini bermaksud untuk menggali fungsi dari Dinas Ekonomi Kreatif dalam Pemberdayaan UMKM perempuan di Kabupaten Sleman. Penelitian menggunakan deskriptif kualitatif, data dikumpulkan secara observasi, wawancara, dan dokumentasi telah digunakan pada studi ini. Hasil studi menginformasikan telah ada dan terus berlanjut upaya pemberdayaan yang dilakukan oleh dinas ekonomi kepada para pelaku UMKM di Kabupaten Sleman. Bentuk pemberdayaan yang dilakukan di antaranya pendampingan dan sosialisasi.
Kata Kunci: Pemberdayaan; UMKM; Pendampingan
 
Abstract: The application of the creative economy has become trendsetters in many countries around the world. The creative economy concept is a new business breakthrough that combines elements of creativity and innovation in economic development. Many previous researchers have conducted research on the MSME sector by paying attention to the phenomenon of the creative economy sector, but in-depth studies on MSMEs are still lacking. This study intends to explore the function of the Creative Economy Service in empowering women's MSMEs in Sleman Regency. This research used descriptive research, data was collected through observation, interviews, and documentation. The study results indicate that there have been and are continuing empowerment carried out by the economic service for MSME actors in the Sleman Regency. Forms of empowerment carried out include mentoring and socialization.
Keyword: Empowerment; MSMEs; Mentoring
X-linked frontometaphyseal dysplasia 1
Authors: Mazur O. Ch. , Baiko S. V. , Kilchevsky A. V. , Mikhalenko E. P. , Morozov S. L. , Stankevich Yu. S. , Kursova T. S. , Poleshchuk Yu. A.
Published: July 2024

X-linked filaminopathies are a diverse group of orphan diseases caused by mutations in the FLNA gene which encodes the cytoskeletal actin-binding protein filamin A. Pathogenic variants in this gene cause a wide range of genetic syndromes with signs of organ and tissue damage — skeletal dysplasia, cardiovascular and renal abnormalities. One of a group X-linked filaminopathies is frontometaphyseal dysplasia 1 (OMIM 305620). A clinical case of a 15-year-old boy with congenital anomalies of the kidney and urinary tract: posterior urethral valves, bilateral megaureter, neurogenic bladder was presented. In addition, the patient had congenital heart disease: atrial septal defect, valvular pulmonary artery stenosis and secondary chronic cicatricial-granular stenosis of the larynx. Phenotypic deviations were manifested by skeletal abnormalities that included facial dysmorphism — prominent brow ridges, wide bridge of the nose, orbital hypertelorism, small pointed chin; high-degree scoliosis; valgus deformity of the lower extremities; contractures of various joints. The child was short stature and had multiple congenital developmental features. New-generation whole-exome sequencing (Illumina, NextSeq 550) made it possible to detect a non-synonymous hemizygous variant of the FLNA gene: c.3557G>A (p.S1186L, rs137853312). The identified mutation was confirmed by Sanger sequencing. Genetic testing of the parents was carried out and the c.3557G>A hemizygous mutation was found in the patient’s mother. The use of NGS makes it possible to identify rare hereditary syndromes and make an accurate diagnosis, which is very important for choosing the right management of patient.
Mucolipidosis type IV in the practice of pediatricians and medical geneticists
Authors: Semyachkina A. N. , Nikolaeva E. A. , Voskoboeva E. Yu. , Kuramagomedova R. G. , Bochenkov S. V.
Published: July 2024

Mucolipidosis type IV is a rare autosomal recessive disease from the group of lysosomal accumulation diseases caused by a malfunction of the cation channel due to mutations in the MCOLN1 gene. The clinical symptom complex includes a combination of neurological symptoms (impaired speech and motor development, spasticity, rigidity), corneal opacity and achlorhydria with iron deficiency anemia. The literature data on this disease and the medical history of a 13-year-old girl who was observed in the Department of Clinical Genetics of the Veltischev Institute are presented. The child had a characteristic clinical picture, including damage to the nervous system: decreased intelligence, muscular dystonia and spasticity, salivation, strabismus, hypoplasia of the corpus callosum; damage to the organ of vision — corneal opacity, cataracts, myopia, photophobia in combination with persistent iron deficiency anemia (apparently due to achlorhydria). The diagnosis was confirmed by the results of DNA diagnostics — a known pathogenic mutation NM_02533.3 was detected in the MCOLN1 gene: c.304C>T (p.Arg102Term) in a homozygous state; in the girl’s mother — in a heterozygous state. A differential diagnosis was made with phenotypically similar diseases, primarily with cerebral palsy, mucopolysaccharidosis, and other types of mucolipidosis. Further medical supervision of the child should be carried out with the obligatory participation of a neurologist, an optometrist, a gastroenterologist, an orthopedist and a nephrologist. Knowledge of the clinical features of pathology ensures more successful medical care with the prevention of complications.
Methods of non-invasive electrocardiology in the detection of myocardial damage after COVID-19 (SARS-CoV-2) infection in young elite athletes
Authors: Makarov L. M. , Komoliatova V. N. , Kiseleva I. I. , Bessportochny D. A. , Akopyan A. G. , Dmitrieva A. V. , Aksenova N. V.
Published: July 2024

The impact of the new coronavirus infection (SARS-CoV-2) on the state of the cardiovascular system in minor athletes is uncertain. The “golden” standard for their detection is cardiac magnetic resonance imaging with gadolinium contrast. However, mass screening of athletes using magnetic resonance imaging has not shown any advantage over conducting research according to indications. An analysis of the results of an in-depth medical examination of 1505 young athletes, members of youth teams of the Russian Federation, who were examined at the Center for Syncope and Cardiac Arrhythmias from September 1, 2021 to June 31, 2022, was carried out. 236 athletes (15.7%) suffered SARS-CoV-2 infection for the 6 months preceding the in-depth medical examination. Stage I of the examination included examination, electrocardiography, echocardiography, and bicycle ergometry. 22 athletes (9.3%) required a more in-depth examination due to the identified changes in the first stage (stage II). It included Holter monitoring with assessment of heart rate turbulence, microvolt alternation of the T wave and heart rate variability, and high-resolution electrocardiography. Seven athletes (32%), with changes identified at this stage, were sent for magnetic resonance imaging (stage III). Based on its results, myopericarditis was diagnosed in 4 cases (1.7% of 236), and the necessary treatment and observation were prescribed. Conclusion. There is a low (less than 2%) involvement of myocardial damage in young elite athletes who have had SARS-CoV-2 infection. Additional methods of non-invasive electrocardiology, such as high-resolution electrocardiography, Holter monitoring with assessment of heart rate variability, heart rate turbulence and microvolt alternation of the T wave, make it possible to determine indications for cardiac magnetic resonance imaging.
Association of genetic variants of hemostatic system genes with venous thrombosis in children born to mothers with a burdened obstetric and gynecological history
Authors: Perevezentsev O. A. , Mamedov I. S. , Burtsev D. V.
Published: July 2024

Thrombophilias are hereditary and acquired conditions characterized by an excessive tendency of the body to form thrombi in the blood vessels. Idiopathic venous thrombosis can often occur in childhood and can also be associated with certain genetic variants of hereditary predisposition to thrombophilia.

Purpose. To analyze the association of 8 genetic variants (F2 20210G>A, F5 1691G>A, F7 10976G>A, F13 G>T, ITGA2 807C>T, ITGB3 1565 T>C, PAI-1–675 5G>4G) with venous thrombosis in children born to mothers with a burdened obstetric and gynecological history.

Material and methods. The patient group included 322 children aged 7 to 14 years (average age 9.3 years), who had a history of episodes of venous thrombosis of various locations, born to mothers with obstetric and gynecological history. The comparison group included 159 healthy children also aged from 7 to 14 years (average age 9.5 years), who did not have a history of episodes of venous thrombosis and who were also born to mothers with obstetric and gynecological history. Molecular genetic analysis was carried out using real-time PCR with automatic analysis of melting curves.

Results. Based on the results of an analysis of the association of genetic variants with venous thrombosis in children born to mothers with obstetric and gynecological history, a connection with this pathology was established for genetic variants F5 1691G>A (genotype GA+AA, OR=3.33, 95% CI: 1.19 — 9.36), ITGA2 807C >T (TT genotype (OR=1.92, 95% CI:1.20 — 3.06) and heterozygous CT (OR=1.46, 95% CI: 1.10 — 1.93)) and ITGB3 1565 T>C (CC genotype (OR=2.77 95% CI:1.08 — 7.02) and TC (OR=1.40, 95% CI: 1.07 — 1.83)).

Conclusion. Thus, we established an association of 3 genetic variants (Leiden mutation, ITGA2 807C>T and ITGB3 1565 T>C) with venous thrombosis in children born to mothers with obstetric and gynecological history.
Análisis de la gestión del marketing digital de los medios oficiales de turismo en América
Authors: Molina Velásquez Edison Rubén , Soto Aguirre Ronald Leonardo , Changoluisa Yanza Alexis Fabricio , Lita Ushiña Melany Lizbeth
Published: July 2024

El marketing digital en la actividad turística es fundamental para la promoción de los países, y las organizaciones deben adaptarse a las nuevas tecnologías para alcanzar rendimientos óptimos que permitan ser competitivos en el mercado. El objetivo de la investigación fue analizar la gestión digital de los medios oficiales en 15 países de América. La metodología utilizada fue de enfoque mixto, con herramientas como SimilarWeb, GTmetrix, Page Speed Insights que permitieron obtener métricas y evaluar la participación de los países, el rendimiento general, el Lighthouse Performance y la velocidad en los dispositivos. En el estudio comparativo de los medios oficiales, se observó un bajo rendimiento en la gestión del marketing digital, y se resaltó la necesidad de mejorar las plataformas web, para atraer más visitas online y aumentar el tráfico web. Finalmente, el estudio realizado demuestra la importancia del manejo digital en el turismo para aportar al aumento de la visibilidad, mejorar el posicionamiento y la efectividad en línea.
Hydraulic investigation of flows at high-head overflow spillway with multiple aerators: a physical and numerical study of Mohmand Dam, Pakistan
Authors: Ali Syed Abbas , Khan Noor Muhammad , Sarwar Muhammad Kaleem , Zaffar Muhammad Waqas , Tariq Atiq Ur Rehman , Ullah Ubaid , Abbas Yasir
Published: July 2024

A spillway is the essential part of the dam body, which releases surplus flows. At higher floods, the spillway operates at high heads, which results in high flow velocities along the chute and may cause negative pressures and cavitation. Therefore, to minimize such issues, aerators are provided along the spillway's chutes. This study aims to analyze the performance of the high-head overflow spillway of Mohmand Dam, Pakistan, having a steep chute of 32° with multiple aerators. Based on Froude's law of similitude, the physical model study was carried out at Irrigation Research Institute, Nandipur, on a scale of 1:60, while FLOW-3D numerical models were used to compare different hydraulic parameters, i.e., flow depth, velocity and pressure. The numerical models were validated with the results of a physical model, which were found in an acceptable range (i.e., 4.93%), and the hydraulic performance of two aerators was evaluated at different discharges. The models indicated negative pressures inside the aerator cavity, which allowed the suction of air to the lower nappe. The maximum air entrainment at the first aerator was about 8.5%. The results also showed that air entrainment to the lower nappe decreased when discharge was increased, whereas the maximum air detrainment reached 11.3% downstream of the second aerator.
Gastroprotective Effect of oenothein B: a Romising Macrocyclic Ellagitannin
Authors: Martins José Luis Rodrigues , Silva Dayane Moreira da , Florentino Iziara Ferreira , Fajemiroye James Oluwagbamigbe , Hungria Pinto Emerith Mayra , Oliveira Thiago Sardinha de , Rocha Fábio Fagundes da , Souza Gil Eric de , Ferreira Anderson Luiz , Santos Suzana da Costa , Silva Osmar Nascimento , Costa Elson Alves
Published: July 2024

A peptic ulcer disease is a significant gastrointestinal disorder with a high prevalence of 80% in developing countries and 40% in developed countries. Oenothein B, a macrocyclic ellagitannin, has emerged as a potential therapeutic agent for this condition. The aim of this study was to investigate the anti-ulcer activity of Oenothein B and elucidate the underlying mechanisms involved in its gastroprotective effects. The anti-ulcer activity of Oenothein B was assessed using various experimental models, including ulcers induced by indomethacin, HCl/ethanol, and pyloric ligation. Several parameters were evaluated, including the quantification of volume, pH, total gastric acidity secretion, as well as catalase and superoxide dismutase activity. The role of prostaglandins in mediating the effects of Oenothein B was also examined. The results demonstrated that Oenothein B exhibited significant anti-ulcer activity when administered intraduodenally at a dose of 15 mg/kg in an acute protocol of induced ulcers. This treatment resulted in a reduction in volume and total gastric acidity secretion. Moreover, oral administration of Oenothein B was found to increase catalase and superoxide dismutase activity in the gastric mucosa. These findings suggest that Oenothein B exerts its anti-ulcer effects by reducing gastric acid secretion and enhancing the activity of antioxidant enzymes. Additionally, the modulation of endogenous prostaglandin levels appears to play a role in mediating these effects. In conclusion, Oenothein B demonstrates promising anti-ulcer activity and may serve as a potential therapeutic option for the management of peptic ulcer disease. Further investigations are warranted to elucidate the detailed mechanisms of action and evaluate its efficacy and safety in clinical settings.
Avaliação de Caracteres Agronômicos de Cultivares de Feijão-Caupi (Vigna unguiculata l.walp.) Cultivados em Esperança-PB
Authors: Silva Francyane Araújo , Silva Priscylla Vital Barboza , Meireles Denisvaldo Artur de , Costa Cássio Ricardo Gonçalves da , Oliveira Márcia Roseane Targino de , Fraga Vânia da Silva , Dias Bruno de Oliveira , Silva Joalison Brito , Araújo Witória de Oliveira , Campos Milton César Costa
Published: July 2024

O Feijão-caupi é uma importante fonte de insumo alimentício global nos últimos anos, contribuindo sob a excelente capacidade de fonte de nutrientes composto por proteínas, carboidratos, fibras, vitaminas e minerais. Logo, o objetivo deste trabalho foi avaliar as características agronômicas de cultivares de feijão-caupi implantadas no município de Esperança-PB. Utilizou-se o delineamento experimental de blocos ao acaso, com 3 blocos e 4 parcelas subdivididas, sendo avaliadas 20 plantas por cada parcela, totalizando 120 amostras. Foram utilizadas 6 variedades de feijão, e avaliado os seguintes parâmetros: comprimento, largura, espessura, peso, umidade, cinza e tempo de cocção. Dentre as cultivares estudadas, cultivar BRS Nova Era foi a que apresentou as melhores médias nos diferentes parâmetros analisados. Já relacionado ao tempo de cocção, todas as variáveis tiveram o seu cozimento em tempo inferior a 26 minutos, mas destacando-se a variável Costela de Vaca apresentando o menor tempo médio de mais ou menos 18 minutos.
Solos na Escola: Uma Experiência Didático-Prática com os Alunos do Ensino Fundamental no Município de Areia- PB
Authors: Bondade Bruno Bernardo , Santos Robson Vinício dos , Silva Joálison de Brito , Campos Milton César Costa , Barbosa José Matheus da Silva , Oliveira Flávio Pereira de , Lima Renato Abreu , Martins Thalita Silva
Published: July 2024

O solo é um componente fundamental do ecossistema terrestre, apesar de sua importância, esse tema, usualmente, não é abordado com a devida relevância no ensino fundamental. Assim, objetivou-se avaliar a percepção dos solos na escola: experiência com estudantes do 6° ano do ensino fundamental em uma escola em Areia – PB. O trabalho foi realizado na Escola Municipal de Ensino Fundamental José Lins Sobrinho, localizada na Vila do Mercado, distrito da Usina Santa Maria, zona rural do município de Areia-PB. O público alvo foram os estudantes de duas turmas do 6° ano do ensino fundamental nos períodos de 2022.2 e 2023.1 divididas em 25 alunos por período, totalizando 50 alunos. Foram aplicados questionários aos estudantes, antes e após as oficinas teóricas e práticas. Verificou-se a interação significativa dos estudantes no decorrer de todas as atividades, percebendo acréscimo no interesse de alguns estudantes e um avanço progressivo no conhecimento.
Meio Ambiente do Trabalho: Nova Disciplina Jurídica
Authors: Ribeiro Marcos André , Menezes Junior Eumar Evangelista , Franco de Oliveira Luis Vicente , Oliveira Silva Iransé , Ribeiro da Costa Matheus André , Santos Filho Iporé José , Santos Alves Vera Lúcia , Galace de Freitas Diego , Franco de Oliveira Rodrigo
Published: July 2024

Este artigo revisita a evolução do “Meio Ambiente do Trabalho” como uma disciplina jurídica inovadora, centrando-se na conexão intrínseca com a Constituição Federal de 1988 e o enfoque proeminente nas doenças ocupacionais. A Carta Magna de 1988, ao consagrar a dignidade da pessoa humana e o direito à saúde como fundamentais, estabelece um novo paradigma na proteção dos direitos laborais. A investigação minuciosa das disposições legais pertinentes destaca a influência direta da Constituição de 1988 na legislação trabalhista, especialmente no âmbito da prevenção e tratamento das doenças ocupacionais. A crescente prevalência dessas doenças destaca a urgência de uma abordagem jurídica que não apenas reaja, mas antecipe e previna efetivamente riscos ocupacionais. Este artigo examina os avanços e desafios decorrentes da consolidação do Meio Ambiente do Trabalho como uma disciplina autônoma. Salienta a importância de uma visão jurídica proativa para antecipar e mitigar riscos ocupacionais, promovendo ambientes laborais mais seguros e saudáveis. A análise propõe uma reflexão sobre como essa nova disciplina, enraizada nos princípios constitucionais, pode orientar a legislação e as práticas laborais em direção a um futuro onde os trabalhadores não apenas tenham seus direitos preservados, mas também desfrutem de ambientes de trabalho que respeitem integralmente sua dignidade e bem-estar.
Geoestatística Aplicada a Atributos Físicos e Químicos em Área com Mandioca na Região de Humaitá, Amazonas
Authors: Oliveira Ivanildo Amorim de , Santos Robson Vinício dos , Silva Douglas Marcelo Pinheiro da , Almeida Romária Gomes de , Freitas Ludmila de , Cunha José Maurício da , Oliveira Flávio Pereira de , Cavalcante Emanuel da Costa , Campos Milton César Costa
Published: July 2024

A mandioca é uma cultura de grande importância regional devido à sua adaptabilidade e excelente fonte de proteína, por outro lado, o sistema de manejo é fundamental para o sucesso do cultivo. O objetivo deste estudo foi utilizar semivariogramas escalonados para determinar a variabilidade espacial e o planejamento amostral de atributos físicos e químicos em um Cambissolo Háplico cultivado com mandioca na região de Humaitá, Amazonas. O experimento foi realizado em um Cambissolo Háplico cultivado com mandioca, estabelecendo-se uma malha de 70 x 70 m. Foram coletadas 64 amostras de solos deformadas e indeformadas com espaçamento regular de 10 m na profundidade de 0,0-0,20 m para determinação dos atributos químicos e físicos. Os dados foram submetidos a análises estatísticas descritivas e geoestatística. Concluiu-se que os atributos físicos apresentam maior variabilidade espacial em relação aos atributos químicos do solo, apresentando alcance de 30 e 42 metros respectivamente no ajuste do semivariograma escalonado. Com base no semivariograma escalonado, para caracterização da variabilidade espacial de atributos físicos e químicos em Cambissolo cultivado com mandioca, a densidade amostral é de 11 e 6 pontos ha-1 respectivamente. O uso de semivariograma escalonado é eficiente na determinação da densidade amostral, pois apresentam valores de alcance próximos aos valores médios dos atributos analisados individualmente.
Etnobotânica no Piauí, Brasil: Panorama Científico e Uso da Flora
Authors: Santos Letícia Sousa dos , Lemos Jesus Rodrigues , Andrade Ivanilza Moreira de
Published: July 2024

A dependência do ser humano das potencialidades que as plantas fornecem tem impulsionado pesquisas acerca dessa interação em todo o mundo. Acontece que as plantas desempenham um papel substancial na vida humana, seja como fonte de alimento, remédio, abrigo, decoração, construção e outros. Nesse contexto, buscamos analisar a produção científica sobre o uso de plantas por comunidades locais/tradicionais no estado do Piauí, inventariar as espécies e as principais utilidades para essas comunidades. Diante disso, foi realizada uma revisão de literatura nas bases de dados SciELO, Web of Science, Scopus, Science Direct, Portal de Periódicos CAPES e Google Acadêmico. Foram reportados 111 artigos científicos nos quais o ano de publicação variou de 2004 a 2023, com destaque para 2015 e 2017. As pesquisas foram realizadas em 67 municípios, com concentração no Norte do estado e Parnaíba foi o município que obteve mais registros (18). O total de 768 espécies foi citado pelas comunidades pesquisadas (agricultores familiares, artesãos, extrativistas, feirantes, horticultores, mantenedores de quintais, pescadores artesanais, quebradeiras de coco e quilombolas). Fabaceae (125) foi a família mais representativa em número de espécies usadas, seguida de Asteraceae (31), Malvaceae (29), Lamiaceae (28) e Euphorbiaceae (27). As espécies foram relatadas, majoritariamente, como recurso medicinal, porém aplicações como alimento e ração, fitocombustível, material e trabalho (construção, artesanato e afins), identidades de apoio (mágico-religiosa), ornamentação e paisagismo, foram observadas. Com essa revisão, foi possível levantar dados etnoflorísticos, destacando as relações entre moradores locais e a flora. Informações sobre o panorama e áreas com lacunas de conhecimento etnobotânico também foram apresentadas, a fim de nortear estudos futuros para um melhor entendimento sobre quais plantas estão sendo utilizadas, fatores que determinam seu uso e como influenciam na qualidade de vida dos piauienses (segurança alimentar, material e trabalho, identidades de apoio, etc).
Üniversite Öğrencilerinde Öz Şefkat ile Affetme Arasındaki İlişkide Psikolojik Esnekliğin Düzenleyici Rolü
Authors: Özdemir Ratibe , Öz Soysal Fatma Selda
Published: July 2024

Bu araştırmanın amacı, üniversite öğrencilerinin öz şefkat ile affetme düzeyleri arasındaki ilişkide psikolojik esnekliğin düzenleyici rolünün incelenmesidir. Bu amaç doğrultusunda üniversite öğrencilerinin affetme, öz şefkat ve psikolojik esneklik düzeyleri arasındaki ilişki ve bu kavramların cinsiyet değişkenine göre anlamlı bir farklılık gösterip göstermediği ele alınmıştır.Araştırma ilişkisel tarama modeli ile desenlenmiştir. Çalışma grubunu 2022-2023 eğitim öğretim yılında Dokuz Eylül Üniversitesi ve Afyon Kocatepe Üniversitesi’nde öğrenim gören 205’i kadın ve 193’ü erkek toplam 398 üniversite öğrencisi oluşturmaktadır. Araştırmada; araştırmacı tarafından hazırlanan “Kişisel Bilgi Formu”, “Heartland Affetme Ölçeği” “Öz Anlayış Ölçeği”, “Psikolojik Esneklik Ölçeği” veri toplama araçları kullanılmıştır. Verilerin analizinde, SPSS 24.0 paket programından yararlanılarak t testi, Pearson korelasyon analizi ve SPSS programına uzantı olarak eklenen Proccess v3.5 modeli ile düzenleyici (Model 1 ) regresyon analizi teknikleri kullanılmıştır. Araştırma sonucunda öz şefkat, psikolojik esneklik ve “öz şefkat X psikolojik esneklik etkileşimi (moderatör)” değişkenlerinin birlikte affetme toplam puanındaki varyansın %41’ini açıkladığı sonucuna ulaşılmıştır. Düzenleyici değişkenin açıklanan varyansa %1.2’lik bir katkısı vardır. Ayrıca üniversite öğrencilerinin affetme, öz şefkat ve psikolojik esneklik düzeylerinin cinsiyet değişkenine göre anlamlı düzeyde farklılık göstermediği bulgulanmıştır. Araştırma kapsamında elde edilen bulgular ilgili alan yazın ışığında tartışılmış, araştırmaya ve uygulamaya yönelik öneriler sunulmuştur.
Efficacy of a supervised exercise program on pain, physical function, and quality of life in breast cancer survivors: protocol for a randomized clinical trial. (Preprint)
Authors: García Molina Jenifer , Saiz Vazquez Olalla , Santamaría Vazquez Montserrat , Ortiz Huerta Juan Hilario
Published: July 2024

BACKGROUND

Breast cancer is the second most common type of cancer in women worldwide. Treatments for this disease can cause various side effects, such as pain, fatigue, loss of muscle mass and decreased quality of life. Physical exercise has proven to be an effective tool to reduce these side effects and improve the quality of life of breast cancer patients.

OBJECTIVE

The purpose of this project is to develop a randomized clinical trial to determine the efficacy of a supervised exercise program on pain, physical function and quality of life in female breast cancer survivors.

METHODS

A randomized, double-blind, clinical trial will be conducted with 325 participants. The intervention group will receive a supervised exercise program for 12 weeks, while the control group will receive no intervention. Participants' pain, physical function and quality of life will be assessed at baseline, post-intervention and 12 weeks post-intervention.

RESULTS

The results of the study are not yet available

CONCLUSIONS

Physical exercise is a promising tool for improving quality of life in female breast cancer survivors. Further research is needed to confirm the efficacy of physical exercise for this population.

CLINICALTRIAL

IO/02072024
DEDIKASI-App, increasing awareness and early detection of common skin diseases in Indonesia through a Mobile-phone Health Application: A Research Protocol (Preprint)
Authors: Abqari Ulfah , Isfandiari Muhammad Atoillah , Richardus Jan Hendrik , Korfage Ida J
Published: July 2024

BACKGROUND

Various media are used to enhance public understanding about diseases. While mobile health (mHealth) applications are widely used, there is little proof for using such apps to raise awareness of skin diseases.

OBJECTIVE

We intend to develop an app (DEDIKASI-apps) to raise awareness of skin diseases, including leprosy. The study will explore baseline awareness, assess the app’s acceptance among community and healthcare workers, and evaluate its effectiveness in enhancing awareness about skin diseases.

METHODS

The study will be conducted in 4 phases; (1) development of the DEDIKASI-app; (2) questionnaire development for awareness study; (3) acceptability testing; and (4) effect measurement of the DEDIKASI-app. We’ll adopt Design Thinking Methodology to develop the app, involving systematic-reviews, expert consultations, FGD, and validation process for questionnaire on skin diseases awareness. We’ll recruit 50 members of community for awareness and acceptability study and one healthcare worker per Puskesmas to assess their perception regarding the app. A randomized controlled trial will be conducted to measure the effectiveness of DEDIKASI-app. Result of awareness level will be categorized into low, moderate, and adequate level, each will be presented with proportions of community.

RESULTS

NA

CONCLUSIONS

Innovative approaches are required to enhance awareness in the community. The study will introduce new tools and insights to address the limited knowledge about detecting skin problems.

CLINICALTRIAL

The ethical clearance of the study has been sought from the Health Research Ethics Committee Faculty of Public Health Universitas Airlangga Surabaya with registration number 160/EA/KEPK/2023. The trial in phase four has been registered to the INA-CRR, the trial study registry of the Ministry of Health, Republic of Indonesia with number INA-O8EX276.
Determinación del Cono de Alta Renta de Santiago de Chile mediante autocorrelación espacial de precios
Authors: Gasic Klett Ivo , Larraín Videla Clemente
Published: July 2024

En esta investigación se analiza la autocorrelación espacial del precio del suelo en Santiago de Chile para comprobar la existencia de un distrito de alta renta, propio de los modelos de ciudades latinoamericanas. Para ello se aplica el Índice de Moran a un conjunto de 206 zonas de mercado dispuestas en una serie de 131 trimestres entre 1983-2016. Los resultados revelan una alta y estable autocorrelación espacial del precio del suelo, lo que confirma un distrito de alta renta, identificado como Cono de Alta Renta (CAR), localizado en las comunas de mayor ingreso de Santiago.
Альбумін-креатинінове співвідношення у сечі: діагностичне та прогностичне значення щодо уражень нирок за умов артеріальної гіпертензії та цукрового діабету 2-го типу (огляд літератури)
Authors: Miloslavsky D.K. , Koval S.M. , Schenyavska O.M.
Published: July 2024

В огляді вітчизняних та закордонних джерел літератури з наукометричної бази PubMed та сучасних європейських керівництв розглядаються аспекти використання чутливого лабораторного маркера альбумін-креатинінового співвідношення у сечі (АКСС), його діагностичного та прогностичного значення щодо уражень нирок серед хворих групи дуже високого ризику, а саме за умов поєднаного перебігу артеріальної гіпертензії та цукрового діабету 2-го типу. Авторами наводяться дані щодо визначення альбумінурії в історичному аспекті, класифікації її проявів, показань до визначення, розглядається питання щодо інформативності та специфічності цього показника як раннього чинника виникнення гіпертрофії лівого шлуночка, серцевої недостатності, діабетичної нефропатії, ожиріння, ліпідних порушень, показника глікемічного контролю, прогнозування серцево-судинних і ниркових наслідків, смертності від цих захворювань. Розглядається питання щодо більшої значущості АКСС порівняно з розрахунковою швидкістю клубочкової фільтрації щодо прогнозування виникнення переддіабету та цукрового діабету, діабетичної ретинопатії. Наводяться дані щодо поширеності, захворюваності та смертності від ниркових ускладнень артеріальної гіпертензії і цукрового діабету 2-го типу, надається стисла характеристика терапевтичних підходів щодо їх корекції.
Exploring the New Interpretation of the Fengshen Story
Authors: Wang Jiashen
Published: July 2024

As a classic Chinese mythology novel, Fengshen yanyi (Investiture of the Gods) is famous for its cultural value, historical value and social value. The story of “Fengshen” is also considered a rich source of inspiration for entertainment and cultural industries in China, influencing a wide range of audiences with diverse backgrounds. As developing the potential “story universe” of Fengshen has become a hot topic in the Chinese film market, reinterpreting Chinese mythology needs to be focused on. Based on the case of the “Fengshen story”, this study aims to explore the new context of Chinese mythology by collecting and analyzing secondary research, categorizing and organizing the findings, and discussing further research from different perspectives, thereby understanding the modern adaptations of traditional Chinese mythology and suggesting a bright future of conducting interdisciplinary research on Chinese mythology in the new context.
An Analysis on the Translation of The Book of Songs from the Perspective of Translation Aesthetics
Authors: Zhang Qingqing
Published: July 2024

The Book of Songs is the first collection of Chinese poems and the representative of Chinese classical culture. It plays an indelible role in the development of Chinese social culture. The Book of Songs not only boasts rhythm in reading, but also has a good effect in meaning expression and rhetoric. Taking the translation of The Book of Songs as an example, this thesis focuses on the study of aesthetic features in Xu Yuanchong’s translation from the perspective of Translation Aesthetics, and analyzes the translation aesthetic principles embodied in the translation cases. Poetry translation can be concluded that it not only requires accurate language, but also needs aesthetic features. Therefore, the translator should analyze the aesthetic features of the original poem before translating the poem, namely the beauty of meaning, sound and form. At the same time, the translator should give full play to his creative ability, and seek for the harmony and unity of meaning, sound and form on the basis of the original text, so as to make the translated poem equal to the original poem in aesthetic function.