bluuebunny/crossref_metadata_2025 huggingface dataset:
The Expressive Dimension of Free Exercise
Authors: Golemboski David
Published: April 2024

Expressivist theories of law focus not only on what legal arrangements do but also what they communicate. The expressivist view has gained special currency in the context of religious establishment. Even when governmental involvement with religion is not coercive or does not materially violate anyone’s rights, it may nevertheless be undesirable by virtue of expressing a preference for a certain religion or a privileged status for certain religious groups over others. The existing literature, however, lacks an equivalent expressivist analysis of the related but distinct domain of free exercise of religion. What is expressed when a religious individual or group is granted special relief from the legal requirements that would otherwise apply to them? I argue that just like religious establishments, religious exemptions not only implicate rights and material interests but also have important expressive dimensions that both help account for their value and impose limits on their desirability.
Colombian Paramilitaries and Their Successor Groups
Authors: Wilson Suzanne B.
Published: April 2024

This essay reviews the following works:

The Frontier Effect: State Formation and Violence in Colombia. By Teo Ballvé. Ithaca, NY: Cornell University Press, 2020. Pp. 228. $27.95 paperback. ISBN: 9781501747540.

Paramilitarismo. Balance de la contribución del CNMH al esclarecimiento histórico. By Centro Nacional de Memoria Histórica (CNMH). Bogotá: Centro Nacional de Memoria Histórica, 2018. Pp. 234. Free e-book. ISBN: 9789585500051.

Agrarian Capitalism, War and Peace in Colombia: Beyond Dispossession. By Jacobo Grajales. New York: Routledge, 2021. Pp. 190. $44.95 paperback. ISBN: 978036775707.

Clientelistic Warfare: Paramilitaries and the State in Colombia (1982-2007). By Francisco Gutiérrez Sanín. Oxford: Peter Lang, 2019. Pp. 480 pages. $72.95 hardcover. ISBN: 9781787073654.

Borderland Battles: Violence, Crime, and Governance at the Edges of Colombia’s War. By Annette Idler. New York: Oxford University Press, 2019. Pp. 496. $29.00 paper. ISBN: 9780190849153.

Organized Violence after Civil War: The Geography of Recruitment in Latin America. By Sarah Zukerman Daly. New York: Cambridge University Press, 2016. Pp. 344. $25.00 paperback. ISBN: 9781107566835.
Existential Inertia and Thomistic Esse
Authors: Boczar Jack
Published: April 2024

In recent years, a considerable amount of interest has arisen in the topic of existential inertia (henceforth EIT)
and its relation to the natural theology of Thomas Aquinas. While contemporary Thomists have engaged with proponents of EIT, strangely enough, no literature has focused on Aquinas’s own response to the objection(s) from an EIT-like position. The intention of this article is to (1) lay out the basic thrust of EIT and then (2) articulate how Aquinas’s own metaphysical commitments dissolve the problems that EIT raises. After formulating an argument based on Aqunias’s own texts and paying attention to the metaphysical commitments it involves, I then level three objections and respond to them.
A Miocene sperm whale (Cetacea, Physeteroidea) tooth from Liessel (Noord-Brabant, the Netherlands)
Authors: Snoodijk Felix , Wallaard Jonathan J. W. , Schulp Anne S. , Reumer Jelle W. F.
Published: April 2024

Here we report a well-preserved isolated physeteroid tooth of Late Miocene age from Liessel, the Netherlands. The presence of several morphological features allows attribution to the macroraptorial physeteroids. Size and morphology are to some extent comparable to Zygophyseter and almost identical to the primarily tooth-based Tortonian taxon Scaldicetus caretti. However, the genus Scaldicetus was declared unutilizable, which is supported here with an overview of modern classifications of Scaldicetus species and specimens. Despite the restrictions, the type species S. caretti is still valid, although the name is to be restricted to the type material. Based on its morphological resemblance, the tooth is identified as Physeteroidea indet. cf. Scaldicetus caretti.
Plastic pollution and human–primate interactions: A growing conservation concern
Authors: Anca Evelyn D. , Wallis Janette
Published: April 2024

As an anthropogenic creation, plastic pollution is a form of human–wildlife interaction and an emerging conservation threat to a growing number of species in both terrestrial and marine environments. Although plastic pollution has spread worldwide and a growing body of literature shows its effects on human health, little is known about its impact on our closest living relatives, nonhuman primates, and their habitats. With over 60% of primate species already under threat of extinction, plastic pollution in their habitats poses a unique problem, exposing them to physical harm, synthetic chemicals, and pathogens through ingestion, entanglement, and oral manipulation. Moreover, through its presence in soil, air, and waterways, plastic pollution leads to environmental degradation and reduces the quality and ecological functionality of primate habitats. This perspective article covers what is known so far about plastic pollution as a conservation threat to nonhuman primates. It is a call for primatologists to address plastic pollution in our research and conservation initiatives. By collecting data on plastic pollution’s presence and assessing its impact on primates and their habitats, we can develop safe protocols and prevention strategies to combat the threat of plastic pollution in the Anthropocene.
Estimation of Groundwater Residence Time Using Radiocarbon and Stable Isotope Ratio in Dissolved Inorganic Carbon and Soil CO2
Authors: Agrawal Rahul Kumar , Mohanty Ranjan Kumar , Rathi Ajayeta , Mehta Shreya , Yadava M G , Kumar Sanjeev , Laskar Amzad H
Published: April 2024

Estimation of residence time of groundwater, particularly in regions with inadequate surface waters are very important for formulating sustainable groundwater management policies. We developed a technique for extracting dissolved inorganic carbon (DIC) quantitatively from water for measuring its 14C contents and presented the analytical details here. We also measured stable carbon isotope ratio (δ13C) in soil CO2 and groundwater DIC to correct the groundwater 14C ages. In addition, 14C in soil CO2 were measured for making necessary correction in the initial activity of the recharging water. The corrected 14C contents in the groundwater samples were used to estimate their residence times employing Lumped Parameter Models (LPM), a set of mathematical models to account for the processes that take place during transport from the recharge to the sampling spots. We present a case study focused on the calculation of radiocarbon ages and residence times for a groundwater sample collected from the campus of Physical Research Laboratory in Ahmedabad, Gujarat, India. The study also includes estimations of groundwater residence times using previously measured 14C ages of groundwater samples from Gujarat, India. Various factors controlling the groundwater ages in the LPM and their applicability are discussed.
A HOMEMADE SEMIAUTOMATIC GRAPHITIZATION DEVICE FOR AMS 14C DATING AT NTUAMS LAB
Authors: Shen Tzu-Tsen , Li Hong-Chun , Qiu Rick
Published: April 2024

A low-cost and computer-controlled graphitization system connected to an elemental analyzer (EA) has been designed and built at the NTUAMS Lab. This semiautomatic system equips 6-unit reactors for the graphitization of CO2 with H2 on the iron catalyst. The entire procedure takes about 7 hours for iron conditioning, sample combustion and loading, and graphitization. The system can produce good-quality graphite for samples containing 0.5–1.6 mg carbon mass, with the pressure yield of graphitization ranging from 57.7% to 87.1%. The average values of OXI and OXII agree well with the consensus value, but the result of ANU sucrose was observed to be slightly higher than the reported one. The background samples of anthracite over ten months yielded an average of 0.38±0.10 pMC (n=21) corresponding to a 14C age of 45 kyr BP. Intercomparison samples L and M of FIRI exhibit that the measured 14C ages are almost identical to the consensus values and have a small spread in these values. The system has been carrying out graphitization for total organic carbon (TOC) of peat samples, and providing a more efficient and convenient way for AMS 14C dating.
A systematic review of the effect of dietary and nutritional interventions on the behaviours and mental health of prisoners
Authors: Poulter Matthew , Coe Shelly , Graham Catherine Anna-Marie , Leach Bethan , Tammam Jonathan
Published: April 2024

Prisoners experience a higher burden of poor health, aggressive behaviours and worsening mental health than the general population. This systematic review aimed to identify research that used nutrition-based interventions in prisons, focusing on outcomes of mental health and behaviours. The systematic review was registered with Prospective Register of Systematic Reviews on 26 January 2022: CRD42022293370. Inclusion criteria comprised of current prisoners with no limit on time, location, age, sex or ethnicity. Only quantitative research in the English language was included. PubMed/Medline, Web of Science, EMBASE, PsycINFO and CINAHL were searched, retrieving 933 results, with 11 included for qualitative synthesis. Studies were checked for quality using the revised tool to assess risk of bias in randomised trials or risk of bias in non-randomised studies of interventions tool. Of the included studies, seven used nutritional supplements, three included diet changes, and one used education. Of the seven supplement-based studies, six included rule violations as an outcome, and only three demonstrated significant improvements. One study included mental health as an outcome; however, results did not reach significance. Of the three diet change studies, two investigated cognitive function as an outcome, with both reaching significance. Anxiety was included in one diet change study, which found a significant improvement through consuming oily fish. One study using diet education did not find a significant improvement in overall mental resilience. Overall, results are mixed, with the included studies presenting several limitations and heterogeneity. Future research should aim to consider increased homogeneity in research design, allowing for a higher quality of evidence to assess the role nutrition can play in improving the health of prisoners.
Weak amenability for dual Banach algebras
Authors: Mahmoodi Amin
Published: April 2024

A suitable notion of weak amenability for dual Banach algebras, which we call weak Connes amenability, is defined and studied. Among other things, it is proved that the measure algebra M(G) of a locally compact group G is always weakly Connes amenable. It can be a complement to Johnson’s theorem that $L^1(G)$ is always weakly amenable [10].
Late Silurian event stratigraphy and facies of South Wales and the Welsh Borderland, United Kingdom
Authors: Hillier Robert D , Waters Richard A , Davies Jeremy R , Higgs Kenneth T , Molyneux Stewart G
Published: April 2024

Lithofacies and biostratigraphical analysis has enabled the establishment of a stratigraphic event framework for Ludfordian and Pridoli strata in south Wales and the Welsh Borderland. In SW Wales, the Golden Grove Axis acted as a structural hinge separating the shallow marine storm-influenced Cae’r mynach Seaway from a pediment surface above which Ludfordian colluvium (Abercyfor Formation) was deposited. The Axis seeded four NW-derived river-influenced delta progrades of Leintwardinian to early Pridoli age (Tilestones Formation). A NE-sourced early Pridoli wave-influenced delta deposited the Downton Castle Sandstone Formation (DCSF), coeval to the youngest Tilestones prograde, with a lateral interface existing between Mynydd Epynt and the Clun Forest area. Except for the Malverns area, the DCSF is no longer recognized south of the Neath Disturbance. Early Pridoli forced regression promoted widespread subaerial exposure north of the Neath Disturbance, with incision into tracts close to the Welsh Borderland Fault System. The basinward-shift in facies belts resulted in marine erosion and deposition of a phosphatic ravinement pebble lag. The wave-influenced Clifford’s Mesne Sandstone Formation delta subsequently seeded on the Gorsley Axis with tidally influenced Rushall Formation accumulating in a back-barrier setting. The Pwll-Mawr Formation records the easterly advance of coeval coastal deposits on the western side of the remnant Cae’r mynach Seaway. Behind migrating delta coastlines, green muds accumulated on coastal plains (Temeside Mudstone Formation) with better drained red dryland alluvium (Moor Cliffs Formation) charting expansion of Old Red Sandstone lithofacies. Mid-Pridoli incision preserves the Pont ar Llechau Formation estuarine valley fill.
Custom Versus Customary Law: Does South African Jurisprudence Draw the Distinction?
Authors: Osman Fatima
Published: April 2024

This article presents a critical analysis of whether South African courts employ established theoretical concepts to delineate the boundaries between custom and customary law. To facilitate a comprehensive understanding, the article begins by providing an overview of the South African legal system, laying the groundwork for the subsequent discussion. The article then delves into prominent theories that address the differentiation between custom and customary law, providing a succinct summary of each. Finally, the article examines the degree to which these theories have been embraced by the courts. Notably, the article uncovers the courts’ emphasis on factors such as certainty and the protection of human rights when deciding whether to apply customary law, rather than relying solely on the distinction between custom and customary law.
Evaluation of epiphytic microbiota in red clover and alfalfa on silage fermentation products, bacterial community diversity and functionality of oat
Authors: Wang Siran , Li Junfeng , Zhao Jie , Dong Zhihao , Nazar Mudasir , Kaka Niaz Ali , Lin Ziqun , Shao Tao
Published: April 2024

The purpose of this experiment was to evaluate the contribution of epiphytic microbiota on alfalfa (AL), oat (OT), and red clover (RC) to ensiling characteristics and bacterial community diversity of oat. With the irradiation of γ-ray, sterile OT (~233 g/kg dry matter (DM)) was inoculated by sterile water (STOT), epiphytic microbiota from OT (OTOT), AL (OTAL) and RC (OTRC), respectively. Triplicate silage-bags for each treatment were sampled after different days (1, 3, 7, 15, 30 and 60) of fermentation, respectively. Similar chemical compositions were found between fresh oat and STOT. Lower (P < 0.05) contents of ammonia nitrogen (NH3-N) and higher (P < 0.05) accumulation of lactic acid were found in OTAL compared with OTRC and OTOT on day 3. The greatest (P < 0.05) NH3-N, acetic acid concentrations and pH and the lowest (P < 0.05) concentration of lactic acid were found in OTRC on day 60. After 3 days of ensiling, Lactobacillus accounted for a big proportion in OTAL and OTOT, and Hafnia-Obesumbacterium was predominant in OTRC. The bacterial communities in OTAL and OTOT had lower (P < 0.05) abundances of ‘Genetic Information Processing’ than OTRC after 3 days. Overall, the composition, diversity, and activity of epiphytic microbiota can notably influence the ensiling characteristics of forage oat. The lactic acid bacteria (hetero-fermentative type) and Enterobacteriaceae species played an important role in producing ethanol contents during the ensiling of forage oat.
The role of using the submucosal conchoplasty technique for the management of concha bullosa in decreasing post-operative middle meatus synechia formation after functional endoscopic sinus surgery: a randomised controlled trial
Authors: Elgendy Ahmed , Khafagy Yasser , Elzayat Saad , Ali Elouny Ali Gamal
Published: April 2024

Objective

The study aimed to compare the applicability of classic lateral lamellectomy versus submucosal conchoplasty techniques in managing concha bullosa during and after functional endoscopic sinus surgery.

Methods

The study randomly divided 56 patients with bilateral concha bullosa into two groups. One group of patients underwent the submucosal conchoplasty technique and the other group underwent the lateral lamellectomy technique. The study compared the intra-operative findings, including the time required for each technique, the amount of intra-operative bleeding and the post-operative endoscopic outcome of the middle meatus and middle turbinate stability.

Results

Submucosal conchoplasty was significantly more time-consuming than the lateral lamellectomy technique (p = 0.001*). The difference in the intra-operative amount of bleeding was (p = 0.086*). The lateral lamellectomy group showed a higher rate of synechia formation in the middle meatus (p = 0.012*).

Conclusion

Submucosal conchoplasty is a valid technique for managing concha bullosa with better post-operative endoscopic outcomes.
Efficacy of intranasal corticosteroid sprays in relieving clinical signs of Eustachian tube dysfunction: a systematic review and meta-analysis of randomised, controlled trials
Authors: Nibhanupudy Tara J. , Patel Aneesh , Trinh Caroline P. , Jenkins Elizabeth , Weber Peter C. , Levi Jessica R.
Published: April 2024

Objective

Eustachian tube dysfunction is prevalent in both paediatric and adult populations. Current clinical guidelines recommend observation over topical intranasal corticosteroids for Eustachian tube dysfunction management, which remains controversial. This study aimed to systematically review randomised, controlled trials assessing topical intranasal corticosteroid efficacy in Eustachian tube dysfunction, and analyse effect through tympanometric normalisation.

Methods

PubMed, EMBASE, Web of Science and Cochrane Library databases were searched. All randomised, controlled trials assessing intranasal corticosteroids in adult or paediatric Eustachian tube dysfunction patients were included. A meta-analysis of proportions was used to evaluate tympanogram normalisation.

Results

Of 330 results, eight randomised, controlled trials met inclusion criteria and underwent qualitative data synthesis and risk-of-bias analysis. Meta-analysis of tympanometry data from four eligible trials (n = 512 ears) revealed no significant difference in tympanometric normalisation between intranasal corticosteroids and control (odds ratio 1.21, 95% confidence interval 0.65–2.24).

Conclusion

Study results do not strongly support intranasal corticosteroids for Eustachian tube dysfunction. Data were limited, emphasising the need for larger, higher quality, randomised, controlled trials.
Gastrointestinal helminths of opossums (Mammalia: Didelphidae) from Bolivia
Authors: Jiménez F. Agustín , Campbell Mariel L. , Byles Beth , Scheibel Raymond Philip , Gardner Scott L.
Published: April 2024

A total of 32 taxa of helminths were recovered from 52 individuals corresponding to 17 species of didelphiomorph marsupials collected across Bolivia. From these, 20 taxa are registered for the first time in this landlocked South American country, including the cestode Mathevotaenia bivittata, and the nematodes Moennigia sp., Travassostrongylus callis, Viannaia didelphis, V. hamata, V. metachirops, V. minispicula, V. philanderi, V. simplicispicula, V. skrjabini, V. viannai, Cruzia tentaculata, Monodelphoxyuris dollmeiri, Neohilgertia venusti, Pterygodermatites elegans, Pterygodermatites jeagerskioldi, Spirura guianensis, Gongylonemoides marsupialis, Turgida turgida and Trichuris reesali. We report for the first time parasites for Marmosops bishopi, Monodelphis emiliae, Monodeplhis glirina, Monodelphis sanctarosae, Monodelphis peruviana and Thylamys sponsorius and document 38 new records of parasites infecting marsupials. Twenty-six taxa of helminths infect 2 or more species of didelphiomorph marsupials, with the exception of Travassostrongylus callis, Viannaia didelphis, V. hamata, V. minispicula and V. hamate, which infected individuals of a single species.
Lives in Music
Authors: Frith Simon
Published: April 2024

One of the more annoying aspects of the life of a popular music academic is that we study music that is primarily made and used by people who seem to have no interest at all in what we have to say. Popular musicians and fans are engaged with what we're talking about but not with how we talk about it. When the first volume of our history of live music came out, covering 1950–67 (Frith et al. 2013), I did some non-academic promotional work for it – presenting our book at a literary festival, library events and pensioners’ clubs (these were the people who had lived through what we were describing). Audiences were, like my non-academic friends, sufficiently interested in live music history to discuss our findings with enthusiasm but, at the same time, found the book unreadable. They couldn't be doing with academic research conventions, with the references constantly interrupting the narrative flow, with the painstaking collection and assessment of evidence, the stolid back and forth between the particular (the facts) and the general (the concepts).
An asymmetric S-curve trajectory planning based on an improved jerk profile
Authors: Han Chol Jun , Song Kwang Rim , Rim Un-Ryong
Published: April 2024

In this paper, a method of planning the expanded S-curve trajectory of robotic manipulators is proposed to minimize the execution time as well as to achieve the smoother trajectory generation in the deceleration stage for point-to-point motions. An asymmetric parameter is added to the piecewise sigmoid function for an improved jerk profile. This asymmetric profile is continuous and infinitely differentiable. Based on this profile, two analytical algorithms are presented. One is applied to determine the suitable time intervals of trajectory satisfying the time optimality under the kinematic constraints, and the other is to determine the asymmetric parameter generating the minimum execution time. Also, the calculation procedure for the time-scaled synchronization for all joints is given to decrease unnecessary loads onto the actuators. The velocity, acceleration, jerk and snap (the derivative of jerk) of the joints and the end-effector are equal to zero at two end points of motion. The simulation results through 3 DOF and 6 DOF robotic manipulators show that our approach reduces the jerk and snap of the deceleration stage effectively while decreasing the total execution time. Also, the analysis for a single DOF mass-spring-damper system indicates that the residual vibration could be reduced to 10% more than the benchmark techniques in case velocity, acceleration and jerk are limited to 1.24 m/s, 6 m/s2 and 80 m/s3, respectively and displacement is set to 0.8m. These results manifest that the performance of reducing residual vibrations is good and demonstrate an important characteristic of the proposed profile suitable for point-to-point motion.
Feminist Rereading of Shabih’khani in Iran
Authors: Azarm Milad
Published: April 2024

This article examines Shabih’khani, a traditional ritual performance in Iran also known as Ta’ziyeh, in the context of the ‘Woman, Life, Freedom’ movement. It includes the historical challenges faced by Iranian women in a patriarchal society dominated by politics and religion, augmenting existing research on women’s Shabih’khani through recently discovered documents that show the erasure of feminine symbols within the tradition. The article also explores the theatrical conventions, dramaturgical elements, and historical reasons for the emergence and decline of women’s Shabih’khani, together with factors that contribute to the endurance of men’s Shabih’khani. By drawing connections and comparisons between Shabih’khani and the contemporary ‘Woman, Life, Freedom’ movement, it illuminates the factors shaping the movement and offers insights into its potential for success and progress.
Embodied Voice Valery Nikolayevich Galendeyev 12.5.1946 – 24.1.2024
Authors: Shevtsova Maria
Published: April 2024

Valery Galendeyev seemed immortal, so steady was his demeanour, so light his ample frame. We knew that he had had serious Covid early in the pandemic but his habitual warmth and gentle irony belied his health’s decline as he continued to work as if it would never stop. He understood, though, that, sooner rather than later, his growing ill heath, which he discreetly set aside, would stop him.
Contemporary Censorship Debates in Germany
Authors: Carlson Marvin
Published: April 2024

During the past five years the cultural world in Germany has been shaken and divided by a series of controversies involving contemporary works of art charged with being anti-Semitic. Obviously, with the Holocaust continuing to occupy a major position in modern German consciousness and history, sensitivity to anti-Semitic expressions is particularly keen here. This sensitivity has been increased by a number of recent developments, including the growing visibility of far-right political groups, the rise of the Boycott, Divestment, and Sanctions movement (BDS) protesting Israeli treatment of the Palestinians, and the official politicization of these tensions by a parliamentary ruling in 2015 restricting the activities of the BDS. The conflict between legitimate criticism of policies of the Israeli state and legitimate censorship of ethnically offensive material has recently become increasingly bitter in Germany. This article discusses the dynamics of three of the most significant recent examples: the conflict involving Germany’s most prestigious arts festival, the Kassell documenta in 2020; the withdrawal in 2022 of the European Drama Award, the continent’s largest award, from British dramatist Caryl Churchill; and the withdrawal from the Munich stage of the most recent play by Wajdi Mouawad, who has been widely heralded in Germany as the most significant contemporary dramatist.
ASYMPTOTICALLY UNIFORMLY MOST POWERFUL TESTS FOR UNIT ROOTS IN GAUSSIAN PANELS WITH CROSS-SECTIONAL DEPENDENCE GENERATED BY COMMON FACTORS
Authors: Wichert Oliver , Becheri I. Gaia , Drost Feike C. , van den Akker Ramon
Published: April 2024

This paper considers testing for unit roots in Gaussian panels with cross-sectional dependence generated by common factors. Within our setup, we can analyze restricted versions of the two prevalent approaches in the literature, that of Moon and Perron (2004, Journal of Econometrics 122, 81–126), who specify a factor model for the innovations, and the PANIC setup proposed in Bai and Ng (2004, Econometrica 72, 1127–1177), who test common factors and idiosyncratic deviations separately for unit roots. We show that both frameworks lead to locally asymptotically normal experiments with the same central sequence and Fisher information. Using Le Cam’s theory of statistical experiments, we obtain the local asymptotic power envelope for unit-root tests. We show that the popular Moon and Perron (2004, Journal of Econometrics 122, 81–126) and Bai and Ng (2010, Econometric Theory 26, 1088–1114) tests only attain the power envelope in case there is no heterogeneity in the long-run variance of the idiosyncratic components. We develop a new test which is asymptotically uniformly most powerful irrespective of possible heterogeneity in the long-run variance of the idiosyncratic components. Monte Carlo simulations corroborate our asymptotic results and document significant gains in finite-sample power if the variances of the idiosyncratic shocks differ substantially among the cross-sectional units.
Feeling signs: Motor encoding enhances sign language learning in hearing adults
Authors: Morett Laura M. , Cieśla Mathew , Bray Mary E. , Emmorey Karen
Published: April 2024

Manual production enhances learning and recall of signs by hearing second language learners; however, the mechanisms enabling this effect are unclear. We examined whether the motor encoding (somatosensory feedback) that occurs during sign production benefits learning and whether it interacts with sign iconicity, which also enhances learning. American Sign Language (ASL) signs varying in iconicity were learned either via production (repetition) with the eyes closed or via observation without production. Signs learned via production were recalled more accurately than signs learned via observation, indicating that motor encoding from manual production enriches the representations of signs. Moreover, the effect of motor encoding interacted with iconicity, suggesting that motor encoding may particularly enhance the recall of signs low in iconicity. Together, these results reveal the importance of somatosensory feedback as a key mechanism underlying the beneficial effect of production on sign learning, demonstrating that feeling one’s own signing promotes learning and recall of signs.
The uses of stools in classical Athens: diphrophoroi in the Parthenon frieze, old comedy, Attic vases and beyond
Authors: Bednarek Bartłomiej
Published: April 2024

The following article discusses the significance of a stool carried by persons referred to in ancient Greek sources (from Old Comedy to Plutarch) as diphrophoroi. As I argue, the iconography suggests that this piece of furniture was often used by attendants responsible for their mistresses’ outfit, make-up and hairstyle. By extension, the most famous representation of two girls with stools on their heads on the east Parthenon frieze can be interpreted as an allusion to the ritual dressing and embellishing of Athena's statue.
Temporal Clustering of Precipitation Driving Landslides Over the Italian Territory
Authors: Banfi F. , De Michele C.
Published: April 2024

The occurrence of multiple precipitation events not‐independent in time, that is, a temporal clustering, is an example of a temporal compounding event. This type of forcing is of great relevance for the occurrence of different natural hazards, like floods and deep‐seated landslides, for which previous soil saturation plays an important role in shaping the associated hazard. Using ERA5‐Land data set and E‐OBS, we firstly investigate the spatial and temporal characteristics of temporal clustering of precipitation over the Italian territory, and we relate it with two oscillation patterns, namely North Atlantic Oscillation (NAO) and Mediterranean Oscillation Index (MOI), and with common synoptic conditions. Then, we explore the role of temporal compounding of precipitation in the generation of different movement types (complex, debris flow, fall, flow, and sliding) using the database of landslides from the Aree Vulnerate Italiane project (in Italian AVI, meaning Areas Affected by Landslides or Floods). From this study it emerges that below average values of NAO and MOI increase the probability of having clustered precipitation events. For all types of landslides, except rock falls, we observed that the majority of the events are preceded by a temporal clustering of precipitation, over longer time windows for complex events, shorter for debris flows. For rock falls, we found also a link with low minimum temperature and freeze‐thaw cycles for winter events and high maximum temperature for summer events. This work contributes to the investigation of temporal clustering of precipitation in connection with natural hazards characterized by a mechanism of saturation.
Energy Transport and Conversion Within Earth's Supercritical Bow Shock: The Role of Intense Lower‐Hybrid Whistler Waves
Authors: Hull Arthur J. , Muschietti Laurent , Agapitov Oleksiy V. , Chaston Christopher C. , Le Contel Olivier , Lindqvist Per‐Arne
Published: April 2024

Detailed analysis of a high Mach number quasiperpendicular Earth bow shock crossing by the Magnetospheric Multiscale (MMS) spacecraft fleet reveal that lower‐hybrid (LH) whistler waves generated in the shock foot region transport energy predominately along the shock surface and slightly toward the shock ramp in the shock normal incidence frame, where wave energy accumulates and is dissipated into the plasma. This suggests the LH whistlers play an integral role in energy reconfiguration at high Mach number collisionless shocks with ramifications to plasma heating. The multipoint observations are used to quantify the wave characteristic parameters (via interferometry), Poynting fluxes, and energy conversion rates D, and to assess their scale dependencies and spatial and temporal properties. The whistler associated energy transport and conversion are found to depend on scale and location within the layer. High‐frequency electrostatic waves yield largest values of D. However, the dominant net energy exchange contribution is from the LH whistlers. In the foot spatially temporally coherent net energy exchange from the plasma to whistlers is observed, whereas deeper in the ramp net wave energy dissipation to the plasma is observed exhibiting significant space‐time variability. These results are consistent with the modified two stream instability driven by the relative drift between reflected ions and electrons as the mechanism for wave growth in the foot. Owing to strong electron heating, whistler energy dissipation in the ramp is attributed to Landau damping, which out‐competes the destabilizing effect of the reflected ion and electron drift.
Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells
Authors: Silva Suellen L. R. , Dias Ingrid R. S. B. , Rodrigues Ana Carolina B. da C. , Costa Rafaela G. A. , Oliveira Maiara de S. , Barbosa Gabriela A. da C. , Soares Milena B. P. , Dias Rosane B. , Valverde Ludmila F. , Rocha Clarissa A. G. , Roy Nainita , Park Christopher Y. , Bezerra Daniel P.
Published: April 2024

Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote the development and progression of AML, and eradication of LSCs is critical for effective control of this disease. Emetine is an FDA-approved antiparasitic drug with antitumor properties; however, little is known about its potential against LSCs. Herein, we explored the antileukemic potential of emetine, focusing on its effects on AML stem/progenitor cells. Emetine exhibited potent cytotoxic activity both in hematologic and solid cancer cells and induced AML cell differentiation. Emetine also inhibited AML stem/progenitor cells, as evidenced by decreased expression of CD34, CD97, CD99, and CD123 in KG-1a cells, indicating anti-AML stem/progenitor cell activities. The administration of emetine at a dosage of 10 mg/kg for two weeks showed no significant toxicity and significantly reduced xenograft leukemic growth in vivo. NF-κB activation was reduced in emetine-treated KG-1a cells, as shown by reduced phospho-NF-κB p65 (S529) and nuclear NF-κB p65. DNA fragmentation, YO-PRO-1 staining, mitochondrial depolarization and increased levels of active caspase-3 and cleaved PARP (Asp214) were detected in emetine-treated KG-1a cells. Moreover, treatment with the pancaspase inhibitor Z-VAD(OMe)-FMK partially prevented the apoptotic cell death induced by emetine. Emetine treatment also increased cellular and mitochondrial reactive oxygen species, and emetine-induced apoptosis in KG-1a cells was partially prevented by the antioxidant N-acetylcysteine, indicating that emetine induces apoptosis, at least in part, by inducing oxidative stress. Overall, these studies indicate that emetine is a novel potential anti-AML agent with promising activity against stem/progenitor cells, encouraging the development of further studies aimed at its clinical application.
Tissue-specific features of innate lymphoid cells in antiviral defense
Authors: Piersma Sytse J.
Published: April 2024

Innate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include type I, type II, and type III immune cells. While NK cells have been well recognized for their role in antiviral immunity, other ILC subtypes are emerging as players in antiviral defense. Each ILC subset has specialized functions that uniquely impact the antiviral immunity and health of the host depending on the tissue microenvironment. This review focuses on the specialized functions of each ILC subtype and their roles in antiviral immune responses across tissues. Several viruses within infection-prone tissues will be highlighted to provide an overview of the extent of the ILC immunity within tissues and emphasize common versus virus-specific responses.
Skin graft with dermis and appendages generated in vivo by cell competition
Authors: Nagano Hisato , Mizuno Naoaki , Sato Hideyuki , Mizutani Eiji , Yanagida Ayaka , Kano Mayuko , Kasai Mariko , Yamamoto Hiromi , Watanabe Motoo , Suchy Fabian , Masaki Hideki , Nakauchi Hiromitsu
Published: April 2024

Autologous skin grafting is a standard treatment for skin defects such as burns. No artificial skin substitutes are functionally equivalent to autologous skin grafts. The cultured epidermis lacks the dermis and does not engraft deep wounds. Although reconstituted skin, which consists of cultured epidermal cells on a synthetic dermal substitute, can engraft deep wounds, it requires the wound bed to be well-vascularized and lacks skin appendages. In this study, we successfully generate complete skin grafts with pluripotent stem cell-derived epidermis with appendages on p63 knockout embryos’ dermis. Donor pluripotent stem cell-derived keratinocytes encroach the embryos’ dermis by eliminating p63 knockout keratinocytes based on cell-extracellular matrix adhesion mediated cell competition. Although the chimeric skin contains allogenic dermis, it is engraftable as long as autologous grafts. Furthermore, we could generate semi-humanized skin segments by human keratinocytes injection into the amnionic cavity of p63 knockout mice embryos. Niche encroachment opens the possibility of human skin graft production in livestock animals.
CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age
Authors: Menon Tejas , Illing Patricia T. , Chaurasia Priyanka , McQuilten Hayley A. , Shepherd Chloe , Rowntree Louise C. , Petersen Jan , Littler Dene R. , Khuu Grace , Huang Ziyi , Allen Lilith F. , Rockman Steve , Crowe Jane , Flanagan Katie L. , Wakim Linda M. , Nguyen Thi H. O. , Mifsud Nicole A. , Rossjohn Jamie , Purcell Anthony W. , van de Sandt Carolien E. , Kedzierska Katherine
Published: April 2024

Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8+ T-cells provide broadly cross-reactive immunity and alleviate disease severity by recognizing conserved epitopes. Despite the IBV burden, only 18 IBV-specific T-cell epitopes restricted by 5 HLAs have been identified currently. A broader array of conserved IBV T-cell epitopes is needed to develop effective cross-reactive T-cell based IBV vaccines. Here we identify 9 highly conserved IBV CD8+ T-cell epitopes restricted to HLA-B*07:02, HLA-B*08:01 and HLA-B*35:01. Memory IBV-specific tetramer+CD8+ T-cells are present within blood and tissues. Frequencies of IBV-specific CD8+ T-cells decline with age, but maintain a central memory phenotype. HLA-B*07:02 and HLA-B*08:01-restricted NP30-38 epitope-specific T-cells have distinct T-cell receptor repertoires. We provide structural basis for the IBV HLA-B*07:02-restricted NS1196-206 (11-mer) and HLA-B*07:02-restricted NP30-38 epitope presentation. Our study increases the number of IBV CD8+ T-cell epitopes, and defines IBV-specific CD8+ T-cells at cellular and molecular levels, across tissues and age.
Room-temperature low-threshold avalanche effect in stepwise van-der-Waals homojunction photodiodes
Authors: Wang Hailu , Xia Hui , Liu Yaqian , Chen Yue , Xie Runzhang , Wang Zhen , Wang Peng , Miao Jinshui , Wang Fang , Li Tianxin , Fu Lan , Martyniuk Piotr , Xu Jianbin , Hu Weida , Lu Wei
Published: April 2024

Avalanche or carrier-multiplication effect, based on impact ionization processes in semiconductors, has a great potential for enhancing the performance of photodetector and solar cells. However, in practical applications, it suffers from high threshold energy, reducing the advantages of carrier multiplication. Here, we report on a low-threshold avalanche effect in a stepwise WSe2 structure, in which the combination of weak electron-phonon scattering and high electric fields leads to a low-loss carrier acceleration and multiplication. Owing to this effect, the room-temperature threshold energy approaches the fundamental limit, Ethre ≈ Eg, where Eg is the bandgap of the semiconductor. Our findings offer an alternative perspective on the design and fabrication of future avalanche and hot-carrier photovoltaic devices.
Spatial decoupling of bromide-mediated process boosts propylene oxide electrosynthesis
Authors: Chi Mingfang , Ke Jingwen , Liu Yan , Wei Miaojin , Li Hongliang , Zhao Jiankang , Zhou Yuxuan , Gu Zhenhua , Geng Zhigang , Zeng Jie
Published: April 2024

The electrochemical synthesis of propylene oxide is far from practical application due to the limited performance (including activity, stability, and selectivity). In this work, we spatially decouple the bromide-mediated process to avoid direct contact between the anode and propylene, where bromine is generated at the anode and then transferred into an independent reactor to react with propylene. This strategy effectively prevents the side reactions and eliminates the interference to stability caused by massive alkene input and vigorously stirred electrolytes. As expected, the selectivity for propylene oxide reaches above 99.9% with a remarkable Faradaic efficiency of 91% and stability of 750-h (>30 days). When the electrode area is scaled up to 25 cm2, 262 g of pure propylene oxide is obtained after 50-h continuous electrolysis at 6.25 A. These findings demonstrate that the electrochemical bromohydrin route represents a viable alternative for the manufacture of epoxides.
Dynamics of Wnt/β-catenin reporter activity throughout whole life in a naturally short-lived vertebrate
Authors: Ogamino Shohei , Yamamichi Moeko , Sato Ken , Ishitani Tohru
Published: April 2024

Wnt/β-catenin signaling plays a major role in regulation of embryogenesis, organogenesis, and adult tissue homeostasis and regeneration. However, the roles played by Wnt/β-catenin and the spatiotemporal regulation of its activity throughout life, including during aging, are not fully understood. To address these issues, we introduced a Wnt/β-catenin signaling sensitive reporter into African turquoise killifish (Nothobranchius furzeri), a naturally ultra-short-lived fish that allows for the analysis of its whole life within a short period of time. Using this reporter killifish, we unraveled the previously unidentified dynamics of Wnt/β-catenin signaling during development and aging. Using the reporter strain, we detected Wnt/β-catenin activity in actively developing tissues as reported in previous reports, but also observed activation and attenuation of Wnt/β-catenin activity during embryonic reaggregation and diapause, respectively. During the aging process, the reporter was activated in the choroidal layer and liver, but its expression decreased in the kidneys. In addition, the reporter also revealed that aging disrupts the spatial regulation and intensity control of Wnt/β-catenin activity seen during fin regeneration, which interferes with precise regeneration. Thus, the employed reporter killifish is a highly useful model for investigating the dynamics of Wnt/β-catenin signaling during both the developmental and aging process.
PARKIN is not required to sustain OXPHOS function in adult mammalian tissues
Authors: Filograna Roberta , Gerlach Jule , Choi Hae-Na , Rigoni Giovanni , Barbaro Michela , Oscarson Mikael , Lee Seungmin , Tiklova Katarina , Ringnér Markus , Koolmeister Camilla , Wibom Rolf , Riggare Sara , Nennesmo Inger , Perlmann Thomas , Wredenberg Anna , Wedell Anna , Motori Elisa , Svenningsson Per , Larsson Nils-Göran
Published: April 2024

Loss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause autosomal recessive early-onset Parkinson’s disease (PD). Extensive in vitro and in vivo studies have reported that PARKIN is involved in multiple pathways of mitochondrial quality control, including mitochondrial degradation and biogenesis. However, these findings are surrounded by substantial controversy due to conflicting experimental data. In addition, the existing PARKIN-deficient mouse models have failed to faithfully recapitulate PD phenotypes. Therefore, we have investigated the mitochondrial role of PARKIN during ageing and in response to stress by employing a series of conditional Parkin knockout mice. We report that PARKIN loss does not affect oxidative phosphorylation (OXPHOS) capacity and mitochondrial DNA (mtDNA) levels in the brain, heart, and skeletal muscle of aged mice. We also demonstrate that PARKIN deficiency does not exacerbate the brain defects and the pro-inflammatory phenotype observed in mice carrying high levels of mtDNA mutations. To rule out compensatory mechanisms activated during embryonic development of Parkin-deficient mice, we generated a mouse model where loss of PARKIN was induced in adult dopaminergic (DA) neurons. Surprisingly, also these mice did not show motor impairment or neurodegeneration, and no major transcriptional changes were found in isolated midbrain DA neurons. Finally, we report a patient with compound heterozygous PRKN pathogenic variants that lacks PARKIN and has developed PD. The PARKIN deficiency did not impair OXPHOS activities or induce mitochondrial pathology in skeletal muscle from the patient. Altogether, our results argue that PARKIN is dispensable for OXPHOS function in adult mammalian tissues.
Reducing short-acting beta-agonist use in asthma: Impact of national incentives on prescribing practices in England and the findings from SENTINEL Plus early adopter sites
Authors: Crooks M. G. , Cummings H. , Morice A. H. , Sykes D. , Brooks S. , Jackson A. , Xu Y.
Published: April 2024

Short-acting beta-agonist (SABA) over-use in asthma is harmful for patients and the environment. The Investment and Impact Fund (IIF) 2022/2023 financially rewarded English primary care networks that achieved specific targets, including reducing SABA over-use (RESP-02) and lowering the mean carbon footprint per salbutamol inhaler prescribed (ES-02). SENTINEL Plus is a co-designed quality improvement package that aims to improve asthma outcomes and reduce asthma’s environmental impact by addressing SABA over-use. We investigated the impact of (i) the IIF incentives and (ii) SENTINEL Plus implementation on asthma prescribing. Using Openprescribing.net data, we demonstrate that IIF 2022-2023 had no significant impact on the total number of SABA prescribed in England (25,927,252 during 12-months pre- and 25,885,213 12-months post-IIF; 0.16% decrease; p=NS), but lower carbon footprint SABA inhaler use increased (Salamol™ prescribing increased from 5.1% to 19% of SABA prescriptions, p < 0.01). In contrast, SENTINEL Plus sites significantly reduced SABA prescribing post-implementation (5.43% decrease, p < 0.05).