bluuebunny/crossref_metadata_2025 huggingface dataset:
Liquid metal neuro-electrical interface
Authors: Zhang Xilong , Liu Chang , Tang Rongyu , Feng Weichen , Gao Jingru , Wu Bingjie , Deng Zhongshan , Liu Jing , Li Lei
Published: June 2024

Liquid metal (LM), an emerging functional material, plays increasing roles in biomedical and healthcare areas. It has particular values in neural interfaces as it combines high conductivity, flowability, and biocompatibility properties. Neuro-electrical interfaces (NEIs) are effective tools to provide a bridge between the nervous system and the outside world. The main target of developing neural interfaces is to help disabled people repair damaged nerves and enhance human capacity above normal ability. This article systematically summarizes LM-based neural interface technologies, including neural electrodes for electrical signal acquisition and administration of electrical stimulation and nerve guidance conduits for neural connectivity and functional reconstruction. The discussion begins with an overview of the fundamental properties associated with LM materials involved in the field of neural interface applications. The fabrication methods of LM-based neuro-electrodes and conduits are then introduced, and the current development status of LM-based neuro-electrodes and conduits is elaborated. Finally, the prospects and possible challenges of LM-based neural interfaces are outlined.
Investing in the long-term: an empirical approach
Authors: Enow Samuel Tabot
Published: June 2024

There has been a proliferation of numerous investment strategies over the years, but one strategy is perceived to have stood the test of time. Investing in the foreseeable future is favored by many successful long-term investors which focus on maintaining a long-term investment horizon. Investing in the long term involves purchasing assets and holding onto them for an extended period, regardless of short-term market fluctuations. Exploring the benefits of this method can help investors make informed selections and build a disciplined investment mindset to achieve their financial goals. The goal of this study was to empirically evaluate the merits of a purchase and hold strategy in financial markets because of its perceived considerable influence on active market players. A Sharpe ratio was utilized for six financial markets from June 13, 2018, to June 13, 2023. The findings revealed that market participants can achieve a sustainable return by simply maintaining a long-term view of their portfolios. This was evident in the Nasdaq, CAC 40 and Nikkei 225. Upon selecting a particular risk tolerance and investment horizon, market participants may earn significant returns on their portfolios.
Influence of environmental stimulation on impulse purchases in shopping malls
Authors: Au-Yeung Chor-Sum , Chao Ren-Fang , Chang Ruei-Lian
Published: June 2024

Impulse purchases play a vital role in the sales revenue of shopping malls. This study utilized the Stimulus-Organism-Response framework to explore how shopping mall atmosphere stimulates consumer emotions, thereby impacting impulse purchase behavior. Structural equation modeling was employed for data analysis. The findings revealed that both positive and negative emotions can act as mediators in the process of forming impulse purchase behavior, albeit with distinct and sometimes antagonistic effects. This phenomenon is attributed to the differential impact of the service atmosphere on stimulating consumer emotions. Additionally, the study identified that only positive emotions can serve as mediators between spatial atmosphere and impulse purchases. In essence, stimuli in the shopping environment can influence consumer emotional responses, thereby prompting impulse purchase behavior.
Exploring the relationship between talent management, work-life balance, and job satisfaction in state-owned banking: a mediation analysis
Authors: Sabrina Clara , Kurniawati Desi Tri
Published: June 2024

The objective of this study is to examine how job satisfaction mediates the relationship between talent management and work-life balance, and employee performance in state-owned banks. The analysis employed quantitative analysis and data collection approaches, namely a questionnaire issued to 127 employees using Google Forms. Performing data analysis utilising the structural partial least squares (SEM-PLS) equation model. The findings indicated that both talent management and work-life balance have a direct and substantial favourable impact on employee performance. This study also discovered that job satisfaction had a role in partially mediating the impact of talent management on employee performance. Job satisfaction somewhat mediates the impact of talent management and work-life balance on employee performance. These findings indicate the importance of consistently focusing on and enhancing talent management methods and work-life balance in order to enhance employee performance.
Literature review of the organizational citizenship behavior of employees in the public sector
Authors: Iqbal Muhammad , Ika Nurul Qamari  , Arni Surwanti
Published: June 2024

This study contributes to our understanding of employee behavior in governmental organizations. This paper aims to demonstrate the effects of organizational culture, transformational leadership, and work motivation on organizational citizenship behavior (OCB). This paper also aims to conduct a literature evaluation on the OCB of the public sector, using VOSviewer to acquire a visual representation of the research's progress. The VOSviewer for visualizing research progress adds value by providing a clear and intuitive representation of the scholarly landscape. Visualizing connections and clusters among documents can facilitate the identification of key themes and research directions. The study searched the Scopus database using the keywords "organizational citizenship behavior public sector," resulting in the discovery of 85 relevant documents. The study analyzed documents published between 2019 and 2023. Afterward, the study selected 25 documents with the highest rankings as references using Publish or Perish. Supplementary documents were discovered through Google Scholar and Proquest. In comparison to other studies, this research is more diverse in the variables, providing integrated information in the public sector. Consequently, this research remains pertinent. Nevertheless, the amount of study conducted on OCB in the public sector has been limited. Therefore, there is a potential for further investigation in this field. The main findings of the study demonstrate that (i) underscore the relevance of promoting a positive organizational culture, fostering transformational leadership, and enhancing work motivation to encourage OCB among public sector employees and finally (ii) the results of this study indicate that influential factors have a positive impact significantly on the OCB in the public sector.
Are hotels meeting customer expectations regarding service quality
Authors: Nyirangondo Marie , Du Bruyn Monique , Dilotsotlhe Nombulelo
Published: June 2024

This study explores customers' perceptions of the service quality provided in the hotel industry in Pretoria, in the Republic of South Africa. Considering the growth of the hotel industry in Pretoria, this study revealed that customers expect to receive a high level of service quality, leading to customer satisfaction and producing a positive perception of hotel service quality. An exploratory research design was adopted, and qualitative data were collected by interviewing hotel customers. Regarding limitations, this study was conducted at one selected hotel in Pretoria. Atlas.ti software was used to analyse the collected data. The analysis of the data identified several specific themes that were relevant to shaping the perceptions of the respondents in terms of service quality and their satisfaction with the service quality received. The themes supported existing literature regarding (i) the factors influencing perceptions of service and (ii) the specific influences within those themes, which were elaborated on, finally leading to recommendations for managing service quality perceptions in the hotel industry.
Optimal Sleep as a Determinant of Healthy Lifespan
Authors: Balasubramani Subramani Paranthaman , R Pandi-Perumal Seithikurippu , Williams John L.
Published: June 2024

Sleep is an essential component of a healthy lifespan, influencing both physical and mental well-being along with good quality of life. Adequate sleep quality and quantity are associated with a host of health advantages, including enhanced immune function, learning and memory, emotional well-being, and cardiovascular health. Chronic sleep deprivation, or poor sleep quality, is associated with a variety of negative health outcomes, including an increased risk of obesity, diabetes, hypertension, depression, cancer, and even premature death. One compelling argument in favor of sleep as a predictor of a healthy lifespan is its effect on cellular repair and regeneration. During sleep, the body goes through important activities such as tissue repair, muscular growth, and memory consolidation. Sleep also helps the brain eliminate toxins and metabolic waste, which contributes to its optimal functioning. Without adequate sleep, these important processes are jeopardized, resulting in accelerated aging and greater susceptibility to chronic illnesses. Furthermore, sleep is essential for maintaining hormone balance, particularly those involved in appetite regulation and metabolism. Sleep disturbances can disrupt the regulation of these hormones, resulting in weight gain, metabolic diseases, and, ultimately, a shorter life span. Finally, prioritizing optimal sleep is pivotal for increasing longevity and general health. Emphasizing the importance of sleep hygiene and treating sleep-related dysfunctions should be part of the modern approach to extending healthy life.
Formulation and Evaluation of Bivalent Swine and Avian Lipid Nanoparticles mRNA Vaccine
Authors: Kassab Mohammed Mahmoud Shawky
Published: June 2024

المستخلص
تصنيع لقاح مكون من الحمض النووي الريبوزي الرسول الخاص بالبروتينات المسئولة عن انتاج البروتينات نيورامنيديز والهيم اجليوتونين لفيروسي الانفلونزا الخنازير والطيورمحاط بجزيئات دهنية بحجم النانوميتر

عدوى انفلونزا الخنازير وانفلونزا الطيور مشكلة خطيرة تؤرق العالم كله هذه الايام خصوصا
انها مميتة لكثير من اطفال العالم . بعد فترة التعافي من الاصابة تتكون المناعة المكتسبة ضدها
لمدة عام تقريبا.
هذه الانفلونزا تسبب تسمم فيروسي في الدم بالاضافة للالتهاب الرئوي
وهذامن بين اكبرالاسباب للوفاة بين الاطفال قبل سن عامين عالميا بشكل مباشر.
الهدف من الدراسة هو انتاج لقاح الحمض النووي الريبوزي الرسول
من نوع الام بالنانوتكنولوجي لبروتينات الهيم اجليوتونين والنيورامنيديز الموجودة على سطح
هذه الفيروسات التي تساعدتها في الاتصاق بالعائل الذي ستتكاثر داخل خلاياه بالجهاز التنفسي.
هذه الدراسة دراسة استكشافية ومن خلالها
استطاعنا تصميم هذا اللقاح باستعمال نظام توصيل للقاح بالنانوتكنولوجي حجم جزيئاته
70نانوميمتر. اللقاح الجديد اظهر فاعلية بنسبة 60% واظهر فاعلية حيوية مقاربة واثار جانبية
اقل بالمقارنة باللقاحات المتوفرة حاليا بالسوق الدوائي ضد هذا النوع من الفيروسات الوبائية.

ABSTRACT
Background:
Worldwide, Swine and Avian influenza, or the H1N1 and H5N1 serotypes of the Influenza A virus, is a highly contagious illness. In recent years, the global incidence of mortality rate has surpassed 284,000 fatalities.
Aim of the study:
The production of mRNA vaccine lipid nanoparticles (LNP) to combat the deadly strains of Avian and Swine influenza (H1N1 and H5N1 of the influenza A serotype).
Methodology:
Polymerase chain reaction (PCR) was used to clone genes of interest encoding Haemagglutinin (HA) and Neuraminidase (NA) of Influenza A virus strains (H5N1 and H1N1) known as Avian flu and Swine flu, respectively. The genes were then inserted using the EcoR1, BAM Hind II restriction endonuclease type II, and Ligase enzyme into the pET-21(+) transcription vector plasmid. On the other hand, the hybrid transcription vectors were mixed with T7 RNA polymerase and ribonucleotides within a test tube after being linearized using EcoR II. Following their purification via reversed-phase high-performance liquid chromatography (RP-HPLC), the mRNAs of the HA and NA were encased in 70 nm LNPs and subjected to reverse-phase high-performance liquid chromatography (RP-HPLC). Lastly, immunogenicity studies were performed in stages 1/2 of randomized human and preclinical clinical trials.
Results:
The bivalent vaccination had around 63% efficacy in preclinical studies and approximately 60% efficacy in randomized human clinical trials. As shown by the ELISA test, strong neutralizing antibodies against HA were prevalent.
Conclusion:
The current study is a promising effort because of the development of the novel LNP-mRNA vaccine, which could lower the incidence of Avian and Swine flu infectious disorders.
The GLP-1 Receptor Agonist Liraglutide Decreases Primary Bile Acids and Serotonin in the Colon Independently of Feeding in Mice
Authors: Nonogaki Katsunori , Kaji Takao
Published: June 2024

Liraglutide, a glucagon-like peptide 1 analog used to treat type 2 diabetes and obesity, is a po-tential new treatment modality for bile acid (BA) diarrhea. Here, we show that administration of liraglutide significantly decreased total BAs, especially the primary BAs, including cholic acid, chenodeoxycholic acid, taurocholic acid, taurochenodeoxycholic acid, glycocholic acid, and β-muricholic acid, in the liver and feces. In addition, liraglutide significantly decreased trypto-phan metabolites, including L-tryptophan, serotonin, 5-hydroxy indole-3-acetic acid, L-kynurenine, and xanthurenic acid, in the colon, whereas it significantly increased in-dole-3-propionic acid. Moreover, the administration of liraglutide remarkably decreased the ex-pression of apical sodium-dependent bile acid transporter, which mediates BA uptake across the apical brush border member in the ileum, ileal BA binding protein, and fibroblast growth factor 15 in association with decreased expression of the BA-activated nuclear receptor farnesoid X receptor and the heteromeric organic solute transporter Ostα/β, which induces BA excretion, in the ileum. Liraglutide acutely decreased body weight and blood glucose levels in association with decreases in plasma insulin and serotonin levels in food-deprived mice. These findings suggest the potential of liraglutide as a novel inhibitor of primary BAs and serotonin in the colon, which may be in-volved in the improvement of BA diarrhea.
Effects of the Methotrexate on HIF-1α, HIF-2α and P4H-TM Levels in Breast Cancer Cells: Results from an In Vitro Study
Authors: Can Orcun , Dumur Seyma , Ergun Dilek Duzgun , Papila Berrin , Afsar Cigdem Usul , Uzun Hafize
Published: June 2024

Background: Methotrexate (MTX) displayed cytotoxic properties against some cancer cells. However, there is very limited data about the possible anti-tumoral potential of them in breast cancer (BC) cells. We aimed to determine the effects of MTX, which is widely used in clinical practice, on cell viability, Hypoxia-inducible factor (HIF) -1α, HIF-2α and prolyl 4-hydroxylase-transmembrane (P4H-TM) in BC cells (MCF-7) and health breast cell (HTERT-HME1) treated with MTX. Methods: Human healthy breast cells (HTERT-HME1) and BC cells (MCF-7) treated with MTX for 24 h, 48h, and 72 h, the effects of MTX on cell viability. Results: The cell viability and with half-maximal inhibitory concentration (IC50) values of of MTX treatment in healthy breast cells were determined to be higher than in MCF-7 cells. MTX showed higher cytotoxicity against MCF-7 cells. MTX significantly reduced cell viability values in HTERT-HME1 and MCF-7 cells. HIF-1α, HIF-2α, and P4H-TM levels was significantly higher in the MCF-7 group than the other groups. Morever, there was a moderate significant correlation between HIF-1α and HIF-2α levels and between HIF-1α and P4H-TM. Conclusions: MTX will show a further decrease in cell viability in long-term treatments of 48 and 72 hours, it is predicted that short-term use may be more appropriate. P4H-TM may be a novel regulator of hypoxia in BC cells. HIF-1α, a key protein responsible for the molecular mechanism of hypoxia in cells, is a key mediator between P4H-TM and hypoxia in MTX-treated cells. HIF-1α, HIF-2α, and P4H-TM values may be markers that can be used as a panel to differentiate BC from healthy women.
Advances in Modeling Approaches for Oral Drug Delivery: Artificial Intelligence, Physiologically Based Pharmacokinetic, and First-Principal Models
Authors: Arav Yehuda
Published: June 2024

Oral drug absorption is the primary route for drug administration. However, this process hinges on multiple factors, including the drug’s physicochemical properties, formulation characteristics, and gastrointestinal physiology. Given its intricacy and the exorbitant costs associated with experimentation, the trial-and-error method proves prohibitively expensive. Theoretical models have emerged as a cost-effective alternative by assimilating data from diverse experiments and theoretical considerations. These models fall into three categories: data-driven models, encompassing classical pharmacokinetics, quantitative-structure models (QSAR), and machine/deep learning. Mechanism-based models include quasi-equilibrium, steady-state, and physiologically based pharmacokinetics, alongside first principles such as molecular dynamics and continuum models. This review provides an overview of recent modeling endeavors across these categories, evaluating their respective advantages and limitations. Additionally, a primer on partial differential equations and their numerical solutions is included in the supplementary materials, recognizing their utility in modeling physiological systems despite their mathematical complexity limiting their widespread application in this field.
Assessment of the Biodegradability and Compatibility of Finished Leathers: Analysis Using Spectroscopy and Thermal Methods
Authors: López Alberto Vico , Bertazzo Marcelo , Maestre-Lopez Maria I. , Arán-Ais Francisca , Orgilés-Calpena Elena , Marhuenda-Egea Frutos C.
Published: June 2024

In this study, the biodegradation properties of leather treated with various finishing chemicals were evaluated in order to enhance the sustainability of leather processing. We applied advanced analytical techniques including FT-IR, thermogravimetric analysis (TGA), and solid-state NMR spectroscopy. Leather samples treated with different polymers, resins, bio-based materials, and traditional finishing agents were subjected to a composting process under controlled conditions to measure their biodegradability. The findings revealed that bio-based polyurethane finishes and acrylic wax exhibited biodegradability, while traditional chemical finishes like isocyanate and nitrocellulose lacquer showed moderate biodegradation levels. The results indicated significant differences in the biodegradation rates and the impact on plant germination and growth. Some materials, such as black pigment, nitrocellulose lacquer and wax, were beneficial for plant growth, while others, such as polyurethane materials, had adverse effects. These results support the use of eco-friendly finishes to reduce the environmental footprint of leather production. Overall, this study underscores the importance of selecting sustainable finishing chemicals to promote eco-friendly leather manufacturing practices.
Acceptability of Medical Male Circumcision as an HIV preven-tion intervention among male learners in a South African high school
Authors: Gotye Lungani , Nomatshila Sibusiso , Maake Kedibone , Chitha Wezile , Mabunda Sikhumbuzo , Nyembezi Anam
Published: June 2024

Abstract: Circumcision is a long-standing and frequently performed surgical procedure which holds significant cultural significance among AmaXhosa people in South Africa. Due to cultural reasons in some parts of Africa, the integration of medical male circumcision with traditional manhood initiation rituals still lacks acceptance. This study examined the level of knowledge and acceptance of voluntary male medical circumcision (VMMC) among young males in a selected high school in the Nyandeni District of the Eastern Cape Province, South Africa. A descriptive, quantitative, cross-sectional study was conducted, and a self-administered questionnaire was used to obtain information on sociodemographic characteristics, knowledge of VMMC, percep-tions of VMMC, and circumcision practices. One Hundred participants were recruited from both grades 11 and 12, and 82% of the participants indicated that they had received information about VMMC. Most of the respondents (88%) preferred traditional male circumcision (TMC) and only 12% of respondents preferred VMMC. The participants displayed a good understanding of the distinction between VMMC and TMC. However, results from the study showed that most re-spondents exhibited low acceptability towards VMMC. These findings highlight the need to develop evidence-based strategies to enhance learners’ knowledge and acceptance of VMMC.
Protein and Amino Acid Metabolism of Thermoanaerobacter mathranii
Authors: Orlygsson Jóhann , Scully Sean Michael , Abraham Clay
Published: June 2024

The members within the genus Thermoanerobacter have been much less investigated for protein and amino acid metabolism as compared with carbohydrates. The present study investigates the biotechnological potential of Thermoanaerobacter mathranii (DSM 11426) concerning its ability to produce high energy alcohols from amino and fatty acids. End-product formation was analyzed from glucose in the presence and absence of butyric acid as well as from selected proteins, and all amino acids. T. mathranii did not degrade any of the proteins tested to a large extent but de-grade several amino acids, namely serine and the branched-chain amino acids (leucine, isoleu-cine, valine) when cultivated in the presence of thiosulfate. The main end products from the branched-chain amino acids were a mixture of their corresponding branched-chain fatty acids and alcohols. 13C2-labeled leucine revealed that the strains degraded the amino acid in the pres-ence of thiosulfate, producing 3-methyl-1-butyrate, which was then used as an electron acceptor which led to the accumulation of 3-methyl-1-butanol. The strain is highly ethanologenic, pro-ducing more than 1.2 mol ethanol per mol of glucose degraded. The strain was able to reduce volatile fatty acids during glucose fermentation to their corresponding alcohol, further suggest-ing this strain may be of greater biotechnological value beyond bioethanol production.
Long-Term Monitoring of Indoor CO Levels in Disproportionately Impacted Communities in the North Denver Metropolitan Area
Authors: Sankhyan Sumit , Hollo Aniya K , Gonzalez-Beltran Dulce , Clements Nicholas , Miller Shelly L.
Published: June 2024

Carbon monoxide (CO) is a colorless, odorless gas emitted from carbon fuel combustion. In this study we monitored indoor carbon monoxide (CO) levels for 120 homes over three seasons in the North Denver metropolitan region as part of an environmental justice initiative to quantify health and social well-being impacts from a major freeway construction upgrade nearby. Urban outdoor CO levels are typically very low (less than 1 ppm in Denver) due to air pollution control strategies and technologies implemented over the past several decades. However, people can still be exposed to higher than outdoor levels of CO in their homes due to the operation of indoor appliances that use carbon fuels such as natural gas. Our data show that ~10% of the homes had consistent daily average levels of CO above 3.5 ppm and 24-57% of the homes showed peaks greater than 9 ppm. While much higher levels can result in CO poisoning and fatalities, these lower levels of CO have been associated with adverse health impacts, especially pregnant women, and sensitive populations. Our results highlight the need for increasing awareness regarding CO exposures in homes with gas appliances and motivate the transition from non-electrified homes toward electrification.
Correlation of Urinary Glyphosate Levels with Whole Blood Selenium Levels among a Representative Sample of US Adults: NHANES 2013-2018
Authors: Chu Pei-Lun , Hsiao Ching-Chung , Wang Chikang , Lin Chien Yu
Published: June 2024

Purpose: Glyphosate and glyphosate-based herbicides (GBH), extensively utilized as herbicides worldwide, have been associated with numerous health issues. Previous experimental studies have indicated their potential to disrupt selenium homeostasis by either interfering with uptake or increasing oxidative stress. However, there is a significant research gap concerning the connection between glyphosate exposure and selenium status in epidemiological studies, particularly within nationally representative samples.
Methods: In this study, we examined data from the 2013-2018 National Health and Nutrition Examination Survey (NHANES), involving 3011 participants aged 3 and above. Our main objective was to examine the connection between urinary glyphosate levels, whole blood selenium, and selenium intake.
Results: Our analysis did not uncover an association between urinary glyphosate and selenium intake. Nevertheless, we observed a negative correlation between urinary glyphosate levels and whole blood selenium, with a ß coefficient of -1.984, S.E. = 0.639, and P = 0.003 in the final model. We also reported a notable decrease in the average concentrations of whole blood selenium as glyphosate tertiles increased, with P-values for trend of 0.033. Furthermore, the association was particularly prominent among females, non-Hispanic whites, and individuals with lower selenium intake.
Conclusions: In this thorough examination of NHANES data, our study uncovers a possible detrimental connection between glyphosate exposure and whole blood selenium levels. These findings underscore the importance of further investigation into the health consequences of glyphosate exposure and its potential influence on selenium status, thereby raising awareness of potential implications for public health.
Diagnostic Potential of miR-143-5p, miR-143-3p, miR-551b-5p and miR-574-3p in Chemoresistance of Locally Advanced Gastric Cancer: A Preliminary Study
Authors: Janiczek-Polewska Marlena , Kolenda Tomasz , Poter Paulina , Kozłowska-Masłoń Joanna , Jagiełło Inga , Regulska Katarzyna , Malicki Julian , Marszałek Andrzej
Published: June 2024

Introduction:
Gastric cancer (GC) is one of the most frequently diagnosed cancers in the world. Although the incidence is decreasing in developed countries, treatment results are still unsatisfactory. The standard treatment for locally advanced gastric cancer (LAGC) is gastrectomy with perioperative chemotherapy.
Aim:
Assessment of selected microRNAs (miRNAs) in chemoresistance in archival material from LAGC.
Material and method:
The research group consisted of archival material from 10 patients with LAGC. Histological material from each patient was used from a biopsy performed during gastroscopy and after surgery preceded by 4 cycles of neoadjuvant chemotherapy (NAC) according to the FLOT or FLO regimen. The expression of selected miRNAs was assessed in the tissue material, such as miRNA-21-3p, miRNA-21-5p, miRNA-106a-5p, miRNA-122-3p, miRNA-122-5p, miRNA-143-3p, miRNA-143-5p, miRNA-203a-3p, miRNA-203-5p, miRNA-551b-3p, miRNA-551b-5p and miRNA-574-3p. miRNA expression was assessed by quantitative chain reaction polymerase reverse transcriptase (qRT-PCR). The response to NAC was assessed by computed tomography of the abdomen, chest and histopathology after gastrectomy. The statistical analyses were performed using GraphPad Prism 9.The significance limit was set at p
Research on the Classification of Work Orders based on BERT and Feature Fusion
Authors: Peng Xiong Yun , Chen Lian Guo , Cao Kuo Jun
Published: June 2024

Convolutional neural networks (CNNs) face challenges in capturing long-distance text correlations, and Bidirectional Long Short-Term Memory (BiLSTM) networks exhibit limited feature extraction capabilities for text classification of work order. To address the abovementioned problems, this work utilizes an ensemble learning approach to integrate model elements efficiently. This study presents a method for classifying work order texts using a hybrid neural network model called BERT-BiLSTM-CNN. First, use Bert for preprocessing to obtain text vector representations. Then, capture context and process sequence information through BiLSTM. Next, capture local features in the text through CNN. Finally, obtain classification results through Softmax. Through comparative analysis, the method of fusing these three models is superior to other hybrid neural network model architectures in multiple classification tasks. It has a significant effect on work order classification.
Upper and Lower Bounds to Pull-Out Loading of Inclined Hooked End Steel Fibres Embedded in Concrete
Authors: Rees David W. A. , Abdallah Sadoon
Published: June 2024

Steel fibre reinforced concrete (SFRC) consists of short hooked steel fibres randomly distributed and oriented within the cementitious matrix. The contribution of fibre in bridging cracks to provide the stress transfer required relies upon the orientation of the fibre in the concrete. Bridging fibre aligned with a crack are less effective than those inclined to it. Therefore, understanding the pull-out behaviour of misaligned fibre is a key factor to quantify and optimize the design of SFRC in the structural applications. In the laboratory a single oriented fibre embedded in a solid cylinder of concrete is subjected to a pull-out test where the axis of a tensile force is aligned with the axis of the cylinder. Based upon the observed behaviour this paper presents a new analytical bounding approach to capture the pull-out response of misaligned hooked-end steel fibre embedded in a concrete matrix. The analysis is based upon a transversely isotropic condition assumed for the plasticity that occurs in the cold drawn fibre. The model accounts for the influence of fibre diameter and the combined strengths of the steel and concrete. The model predictions have also been compared with other experimental results published in the literature. The results showed that the model can predict pull-out loads reasonably for different fibre orientations between bounds of failure derived from the strengths of the two constituents. A critical orientation is observed at maximum strength. Therein, an understanding of the pull-out behaviour of misaligned, hooked-end fibres is necessary to optimize the strength of concrete from this method of reinforcement.
Approximations in Mean Square Analysis of Stochastically Forced Equilibria for Nonlinear Dynamical Systems
Authors: Bashkirtseva Irina
Published: June 2024

Motivated by important applications to the analysis of complex noise-induced phenomena, a problem of the constructive description of randomly forced equilibria for nonlinear systems with multiplicative noise is considered. Using apparatus of the first approximation systems, we construct an approximation of mean square deviations that explicitly takes into account the presence of multiplicative noise. This approximation is compared with the widely used approximation based on the stochastic sensitivity technique. The general mathematical results are illustrated with the example of the van der Pol oscillator with hard excitement.
On Mittag-Leffler Function and Consequent Fractional Integral Operator Inequalities
Authors: Liu Yonghong , Farid Ghulam , Hassaballa Abaker A. , Ro Jongsuk , Bashier Mnahil M. , Younis B. A.
Published: June 2024

The unified Mittag-Leffler (ML) function is important factor in formulation of compact form of fractional integrals. In this paper estimations of integral operators, with the unified ML function as kernel are given. The Hadamard inequality in the form of fractional integrals is proved by considering refinement of convexities. These estimations provide various inequalities as refinements of recently published results.
Lactonization of α-Ferrocenyl Ketocarboxylic Acids via Nucleophilic Attack of Carbonyl Oxygen
Authors: Pokharel Uttam , Curole Brennan , Andras Autumn , LeBlanc Brandon , Fronczek Frank
Published: June 2024

The effects of the ferrocenyl moiety to enhance the nucleophilicity of the carbonyl group, situated at its adjacent position, have been explored in a series of α-ferrocenyl ketocarboxylic acids. In the presence of trifluoroacetic anhydride, 3-ferrocenoylpropionic acid and 4-ferrocenoylbutyric acid gave 5-ferrocenyl-4-trifluoroacetyl-2(3H)-furanone and 6-ferrocenyl-5-trifluoroacetyl-3,4-dihydropyran-2-one, respectively. Under similar reaction conditions, 2-ferrocenylcarbonylbenzoic acid, a keto carboxylic acid without a β-hydrogen, gave a dimerized lactone, 3,3’-diferrocenyl-3,3’-diphthalide possibly due to radical coupling. The nucleophilic attack of carbonyl oxygen, activated by the ferrocenyl moiety, to the carboxylic carbon, is assumed to be the crucial mechanistic step in forming these lactones. When the carbonyl group was reduced to an alcohol to break its conjugation with the ferrocenyl moiety, saturated lactones were isolated after the acidic workup. These results indicate that the α-ferrocenyl carbinols readily undergo solvolysis under acidic conditions, giving ferrocenylcarbenium ions, which are attacked by the carboxy oxygen to give lactones.
Male Body Odor Affects Emotional State, LH and Cortisol Secretion in Women of Different Age Groups
Authors: Laktionova Tatiana , Kvasha Ilya , Voznessenskaya Vera
Published: June 2024

Hormone changes across women's menstrual cycle may lead to changes in perception of chemical signals and hormonal responses to these cues. The aim of the present study was to determine the role of menstrual cycle phase on the effects of extracts of male axillary secretions (EMAS) in women. We tested healthy reproductive age and premenopausal women (n=29). EMAS/control solution was applied once in two hours either in the follicular or luteal phase, while collecting saliva samples for LH and cortisol monitoring. LH and cortisol concentrations were analyzed using EIA technique. PANAS and VAS were used to assess the mood. We observed a significant increase in the number of LH peaks (p=0.0447) and their amplitude (p=0.0469) when EMAS was applied in the follicular phase. The same application in the luteal phase lowered the amplitude of LH peaks (p=0.0382). EMAS application increases salivary cortisol level in reproductive age women relative to premenopausal women (p=0.0032). PANAS revealed changes in positive and negative affect after EMAS application. Our data indicate the significance of the menstrual cycle phase for EMAS effects on LH secretion, mood, but not on cortisol secretion in women.
Optimization Of The Search For Neuroprotectors Among Bioflavonoids
Authors: Belenichev Igor , Ryzhenko Victor , Popazova Olena , Bukhtiyarova Nina , Gorchakova Nadia , Oksenych Valentyn , Kamyshnyi Oleksandr
Published: June 2024

For the first time to optimize the creation of new neuroprotective agents based on bioflavonoids, we applied information technologies - docking analysis to calculate the binding of candidate molecules to the pharmacological target protein transthyretin, as well as the program of virtual screening of NO scavengers. As a result of this approach, the substance catechin was isolated from candidate molecules - quercetin, catechin, Epicatechin gallate, Epicatechin, Procyanidin B1, Procyanidin B2, Procyanidin B3, Catechin-3-gallate according to docking analysis. As a result of virtual screening, catechin was identified as a potential NO scavenger (55.15% prediction). The results of the prediction were confirmed by in vitro experiments. Course administration of catechin to animals with experimental multiple sclerosis (MS) against the background of methylprednisolone administration completely eliminated lethal cases, reduced the number of diseased animals by 20%, as well as prevented the development of severe neurological symptoms by 20% (compared to the methylprednisolone group) and by 60% compared to the control group. Course administration of catechin with methylprednisolone leads to decrease of neurodegradation markers in the cytosol of rats with EAE: NSE by 37%, and S-100 - by 54.8%. The combined administration of methylprednisolone significantly exceeds the combination of methylprednisolone with the reference drug mexidol by the degree of NSE reduction. The obtained results indicate a significant neuroprotective effect of ocular combinations of methylprednisolone and catechin. The above-mentioned confirms the correctness of bioflavonoid selection with the help of virtual screening program.
Transnasal Brain Sampling for Human Rabies Confirmation
Authors: Djimatey Moses Barima , Abubakar Abdul-Rahim , Sylverken Augustina Annan , Odoom Theophlius , Abubakari Braimah Baba , Ohemeng John Akwasi , Yale Gowri , Lohr Frederic , Gamble Luke , Mahadevan Anita
Published: June 2024

Rabies remains a significant global threat, yet accurate estimations of its impact are hindered by the lack of confirmatory diagnoses. Postmortem confirmation of rabies traditionally involves invasive brain tissue testing, a process met with resistance from deceased patients' families, impeding consent. This paper presents and evaluates an innovative yet unpublished transnasal approach for postmortem brain tissue collection, offering a minimally invasive, easier, faster, and safer method. This method preserves the cadaver's integrity, potentially easing family reluctance towards autopsies. The limited testing of both human and animal rabies in Ghana highlights the challenges in diagnosing this fatal disease. Scarce diagnostic resources and the complexity of obtaining brain tissue samples exacerbate the issue. Cultural and religious beliefs surrounding autopsies contribute to familial hesitation, viewing these procedures as disruptive and disfiguring, further complicating consent. The transnasal technique involves approaching the brain tissue through the nostrils and cribriform plate without any superficial manipulation of the patient's head and face, thereby preserving aesthetics and natural features of the person. Technological advancements and seamless One Health collaboration among governmental, non-governmental, and research entities locally and globally culminated in Ghana's first confirmed rabies diagnosis using this method of brain tissue collection. This success emphasizes the efficiency and feasibility of transnasal brain collection approach and the invaluable role of the One Health approach and collaborative efforts in overcoming diagnostic challenges in rabies control.
Study on Overseas Readers' Evaluation and Dissemination Effect of the English Translation of Romance of the Three Kingdoms
Authors: Zhu Zhuolu , Yu Shiyi , Wang Juan
Published: June 2024

In evaluating the translation quality and translation value of literary works, one of the most important assessment links is to focus on the degree of acceptance of translations by readers. Through the study of overseas readers' evaluations and dissemination effects of English translations, we can comprehensively and accurately assess the impact of different translations on readers, provide more scientific guidance and decision-making basis for the translations of classical literature, and promote the dissemination of Chinese literature overseas, thereby contributing to the enhancement of China's cultural soft power. It can provide more scientific guidance and decision-making basis for the translation of classical literature, promote the overseas dissemination of Chinese literature, and boost the enhancement of the soft power of Chinese culture. This study collects readers' evaluations of Martin Palmer's English translation of Romance of the Three Kingdoms, which is ranked first in the review data on Amazon and the official website of Goodreads, through the Octopus data collector, and conducts text data mining on it, utilizing the KHCoder text analyzing tool and adopting a combination of qualitative and quantitative methods, to analyze the readers' reviews of the high-frequency words and semantic mapping were analyzed. It was found that the factors affecting overseas readers' evaluation of the English translation of Romance of the Three Kingdoms include: the length of the full translation, the confusion and difficulty in memorization and phonetic comprehension of Chinese character names due to the names and words in the English translation, and the completeness of the translation in retaining the essence of the original work. Therefore, the subsequent translation of Romance of the Three Kingdoms not only needs to grasp the two perspectives of linguistic accuracy and cultural adaptation, but also should take more account of the preferences and needs of overseas readers, and optimize and adjust these aspects in a targeted manner.
Innovation in Facility Layout Optimization through Heavy Equipment Repair revolution
Authors: Prediansyah Mochamad Afan Wahyu , Cahyana Atikha Sidhi
Published: June 2024

This study addresses the challenge of prolonged forklift repair times at PT Karya Mitra Teknik, a heavy equipment repair company, attributed to inefficient facility layout. Through field observations and stakeholder interviews, Activity Relationship Chart (ARC) and Analysis Allocation Diagram (AAD) methods were applied to identify inefficiencies and propose layout improvements. Results show a significant reduction in total repair area distance from 110 meters to 55 meters, indicating enhanced operational efficiency. The findings underscore the importance of optimizing facility layout in heavy equipment repair workshops to streamline operations and reduce repair turnaround times, offering practical implications for similar industries seeking cost-effective solutions.
Highlights:
1. Efficient facility layout reduces repair area distance.2. ARC and AAD methods streamline resource allocation.3. Optimal layout enhances operational efficiency, reduces turnaround times.
Keywords: Facility Layout Optimization, Heavy Equipment Repair, Operational Efficiency, Activity Relationship Chart (ARC), Analysis Allocation Diagram (AAD)
Optimized Smart Home Temperature Monitoring Using IoT
Authors: Putra Dandi Pratama , Ayuni Shazana Dhiya
Published: June 2024

This research aims to monitor residential home temperatures using the Internet of Things (IoT) and Google Sheets. By adopting a Research and Development (R&D) approach, the study designs and tests a temperature monitoring tool with DHT11 sensors, NodeMCU ESP8266, and LCD displays. Data is integrated into Google Sheets for real-time access. The results show improved service efficiency, reducing waiting times to 0.41-2.45 minutes, with fewer waiting customers and lower utilization rates. This system enhances living conditions by providing easy temperature monitoring, recommending future studies to extend data collection periods for comprehensive analysis. Highlight:   Efficient Monitoring: Real-time temperature data via Google Sheets. Integrated System: Uses DHT11 sensors and NodeMCU ESP8266. Research Implications: Extend data collection for thorough analysis.   Keywoard: Temperature Monitoring, Internet of Things, Google Sheets, DHT11 Sensors, NodeMCU ESP8266
Management of Traumatic Dental Injuries among Otolaryngologists in Southwestern Mainland China: a cross-sectional observational survey
Authors: Pan Zhongjing , Zeng Qinghan , Ma Tianpei , Peng Yuanyuan , Zhang Jinyi , Xu Jue , Lu Dan
Published: June 2024

Background
This study aimed to examine otolaryngologists' attitudes and knowledge regarding the management of traumatic dental injuries (TDIs) encountered when patients present at the emergency department or during procedures such as tonsillectomy,adenoidectomy and suspension laryngoscopic surgery, as well as their motivation for pursuing additional education in this area.
Methods
A cross-sectional observational survey involving otolaryngologists selected from multiple hospitals across Sichuan Province was carried out in this study. The questionnaire, consisting of 31 questions, was segmented into three sections: demographic data (10 items), knowledge about the management of TDI (17 items), and attitudes toward acquiring dental trauma education (4 items). Descriptive analysis, the Kruskal–Wallis test, the Mann–Whitney U test and ANOVA were used for statistical analysis.
Results
In the analysis, a total of 214 surveys were included, with over half of the participants (60.3%) having experienced at least one TDI case in their practice, while four in ten (39.7%) reported never encountering any cases. Participants who had a longer duration of practice were more likely to have a large caseload on the TDI (χ2 = 29.44, p < 0.001). Seventy-one percent of participants experienced TDI during the perioperative period; however, only 6/214 participants (2.8%) responded correctly to all three questions about emergency management of TDI, and nearly all participants (98.1%) chose to refer TDI patients to a dentist. The majority of participants (91.1%) stated that they had not received any training on TDI, and 94.4% were willing to receive TDI-related education.
Conclusions
The findings of this study highlight the inadequate knowledge of otolaryngologists in southwestern mainland China regarding the management of TDI. Furthermore, the results indicate a strong interest among otolaryngologists in pursuing further training, which could help meet the educational needs necessary for providing appropriate management of TDI patients. Hence, it is imperative to provide targeted training courses to ensure prompt and appropriate TDI treatment, thereby minimizing the associated medical and societal costs.
Application of Low Density Polyethylene (LDPE) Passive Samplers for Monitoring PAHs in Groundwater
Authors: Ola Ibukun , Drebenstedt Carsten , Burgess Robert M. , Allan Ian J. , Hoth Nils , Külls Christoph
Published: June 2024

Equilibrium passive sampling continues to find increasing use for performing in-situ assessments and monitoring of hydrophobic organic compounds (HOCs). Although this method has been successfully used in several field studies including open surface waters and sediments, comparatively, their use in groundwater has been very limited. In this study, low density polyethylene (LDPE) passive samplers were deployed for 80 d in three groundwater wells contaminated with polycyclic aromatic hydrocarbons (PAHs). Prior to deployment, LDPE was loaded with performance reference compounds (PRCs) consisting of deuterated PAHs and their release used to ascertain system equilibrium. Within the 80-d deployment period, LDPE-groundwater equilibrium was confirmed for PAHs with molecular weights (MW) in the range of 178 to 228 (i.e., anthracene, chrysene). Measured freely dissolved concentrations (Cw) were between one to three orders of magnitude lower than the total filtered concentrations (Ctotal) in the studied wells. The sum of PAHs (ΣPAHs) measured based on Cw and Ctotal were 2.05, 0.07, and 29.2 μg L-1 and 197, 59.7 and 1010 μg L-1, at wells 1, 2, and 3, respectively. A separate dataset, comprising long-term (2010 to 2022) concentrations of PAHs in total (i.e., unfiltered) groundwater is also presented to provide insight into PAH contamination levels at the assessed groundwater wells based on conventional measurement. Estimated in-situ LDPE daily clearance volumes (2.34 to 27.56 Ld-1) for the target analytes were far less than the daily turnover of ground water (144 to 348 Ld-1) encountered in the wells eliminating the possibility of depletive sampling of the groundwater by the passive samplers. These results represent the first published study on the practical application of equilibrium passive sampling using LDPE for monitoring and quantitatively assessing PAHs in groundwater. Also, this work demonstrates, LDPE are a useful tool for measuring the Cw of PAHs in groundwater, a critical contaminant in many ecological and human health risk assessments.