bluuebunny/crossref_metadata_2025 huggingface dataset:
How Can a Deep Learning Algorithm Improve Fracture Detection on X-rays in the Emergency Room?
Authors: Reichert Guillaume , Bellamine Ali , Fontaine Matthieu , Naipeanu Beatrice , Altar Adrien , Mejean Elodie , Javaud Nicolas , Siauve Nathalie
Published: June 2021

The growing need for emergency imaging has greatly increased the number of conventional X-rays, particularly for traumatic injury. Deep learning (DL) algorithms could improve fracture screening by radiologists and emergency room (ER) physicians. We used an algorithm developed for the detection of appendicular skeleton fractures and evaluated its performance for detecting traumatic fractures on conventional X-rays in the ER, without the need for training on local data. This algorithm was tested on all patients (N = 125) consulting at the Louis Mourier ER in May 2019 for limb trauma. Patients were selected by two emergency physicians from the clinical database used in the ER. Their X-rays were exported and analyzed by a radiologist. The prediction made by the algorithm and the annotation made by the radiologist were compared. For the 125 patients included, 25 patients with a fracture were identified by the clinicians, 24 of whom were identified by the algorithm (sensitivity of 96%). The algorithm incorrectly predicted a fracture in 14 of the 100 patients without fractures (specificity of 86%). The negative predictive value was 98.85%. This study shows that DL algorithms are potentially valuable diagnostic tools for detecting fractures in the ER and could be used in the training of junior radiologists.
RETRACTED: Functionalized Biomass Carbon-Based Adsorbent for Simultaneous Removal of Pb2+ and MB in Wastewater
Authors: Zhang Nannan , Cheng Nan , Liu Qing
Published: June 2021

It is of great significance to realize the sustainable development of the environment to synthesize functional materials by value-added utilization of waste resources. Herein, a composite material of polyacrylic acid/lignosulfonate sodium/cotton biochar (PAA/LS/BC) was successfully prepared by grafting polyacrylic acid with functionalized waste cotton biochar and lignosulfonate sodium. The obtained absorbent showed prominent capture ability toward Pb2+ and methylene blue (MB) with capture characteristics of the pseudo-second-order model and Langmuir isotherm model. This experiment explored the adsorption performance of the adsorbent for pollutants at different conditions, and further revealed the selective adsorption of Pb2+ and MB in the mixed system. Analysis confirmed that electrostatic attraction and complexation are the most critical methods to remove contaminants. Additionally, the regeneration and stability experiment showed that the adsorption capacity of PAA/LS/BC for pollutants did not significantly decrease after five runs of adsorption–desorption. Various results can demonstrate that the adsorbent has excellent performance for removing pollutants and can be used as a material with development potential in the field of adsorption.
The Effect of Sandblasting on Properties and Structures of the DC03/1.0347, DC04/1.0338, DC05/1.0312, and DD14/1.0389 Steels for Deep Drawing
Authors: Krawczyk Janusz , Bembenek Michał , Frocisz Łukasz , Śleboda Tomasz , Paćko Marek
Published: June 2021

The erosion phenomenon has a significant influence on many metallic materials used in numerous industrial sectors. In this paper, we present the results of an analysis of the influence of abrasive impact erosion on surface and properties of DC03/1.0347, DC04/1.0338, DC05/1.0312, and DD14/1.0389 deep drawing steels. The chemical composition, static tensile tests, hardness tests, drawability tests, erosion tests, microstructure analysis, surface roughness, and hardness of the plates were investigated. The wear mechanisms and wear behavior of the investigated steels were also discussed. The results obtained in this study allowed the assessment of the microstructural changes in deep drawing steels under the influence of intense erosive impact. The obtained results indicate that the erosive impact may cause a significant grain refinement of the microstructure of the surfaces of the investigated materials. Moreover, large amounts of heat released during erosive impact may cause the material phase changes. This research expands the knowledge on specific mechanisms taking place during sandblasting and their influence on the properties of deep drawing steels and their wear behavior.
Novel High-Entropy Aluminide-Silicide Alloy
Authors: Novák Pavel , Nová Kateřina
Published: June 2021

Novel high-entropy (multi-principal elements) alloy based on Fe-Al-Si-Ni-Ti in equimolar proportions has been developed. The alloy powder obtained by mechanical alloying is composed of orthorhombic FeTiSi phase with the admixture of B2 FeAl. During spark plasma sintering of this powder, the FeSi phase is formed and the amount of FeAl phase increases at the expense of the FeTiSi phase. The material is characterized by a high compressive strength (approx. 1500 MPa) at room temperature, being brittle. At 800 °C, the alloy is plastically deformable, having a yield strength of 459 MPa. The wear resistance of the material is very good, comparable to the tool steel. During the wear test, the spallation of the FeSi particles from the wear track was observed locally.
Structural and Thermal Investigations of Co(II) and Ni(II) Coordination Polymers Based on biphenyl-4,4′-dioxydiacetate Linker
Authors: Głuchowska Halina , Łyszczek Renata , Mazur Liliana , Kirillov Alexander M.
Published: June 2021

Two coordination polymers, [Co(µ4-L)(H2O)2]n (1) and [Ni(µ-L)(H2O)4]n (2), were solvothermally assembled from the corresponding metal(II) chlorides and biphenyl-4,4-dioxydiacetic acid (H2L) as a flexible dicarboxylate linker. The cobalt(II) compound 1 featured a layer-pillared 3D metal-organic network with a cds topology, while the nickel(II) derivative 2 represented a linear chain 1D coordination polymer with a 2C1 topology. The µ4− and µ-L2− linkers exhibited different denticity and coordination modes in the synthesized compounds, thus contributing to their structural diversity. The dimensionality of 1 and 2 had an influence on their thermal stability and decomposition processes, which were investigated in detail by TG-DSC and TG-FTIR methods. Thermal decomposition products of coordination polymers were also analyzed by PXRD, confirming the formation of Co3O4/CoO and NiO as final materials. The obtained compounds broaden a family of coordination polymers assembled from flexible dicarboxylate linkers.
Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications
Authors: Xu Zhanyan , Omar Abdalla M. , Bartolo Paulo
Published: June 2021

Ideal bone scaffolds for tissue engineering should be highly porous allowing cell attachment, spreading, and differentiation and presenting appropriate biomechanical properties. These antagonistic characteristics usually require extensive experimental work to achieve optimised balanced properties. This paper presents a simulation approach to determine the mechanical behaviour of bone scaffolds allowing the compressive modulus and the deformation mechanisms to be predicted. Polycaprolactone scaffolds with regular square pores and different porosities were considered. Scaffolds were also printed using an extrusion-based additive manufacturing and assessed under compressive loads. Similar designs were used for both simulation and fabrication steps. A good correlation between numerical and experimental results was obtained, highlighting the suitability of the simulation tool for the mechanical design of 3D-printed bone scaffolds.
Predictive Modelling and Multi-Objective Optimization of Surface Integrity Parameters in Sustainable Machining Processes of Magnesium Alloy
Authors: Danish Mohd , Rubaiee Saeed , Ijaz Hassan
Published: June 2021

Magnesium alloys are widely used in numerous engineering applications owing to their superior structural characteristics. However, the machining of magnesium alloy is challenging because of its poor machinability characteristics. Therefore, this paper investigates the machining of magnesium alloys under different sustainable cooling conditions. The machining was performed by varying cutting velocity, feed rate, and depth of cut under dry and cryogenic cooling conditions. The primary focus of the paper is to develop a predictive model for surface roughness under different machining environments. The models developed were found to be in excellent agreement with experimental results, with only 0.3 to 1.6% error. Multi-objective optimization were also performed so that the best surface finish together with high material removal rate could be achieved. Furthermore, the various parameters of surface integrity (i.e., surface roughness, micro-hardness, micro-structures, crystallite size, and lattice strain) were also investigated.
Vibratory Powder Feeding for Powder Bed Additive Manufacturing Using Water and Gas Atomized Metal Powders
Authors: Sinclair Chad W. , Edinger Ralf , Sparling Will , Molavi-Kakhki Amin , Labrecque Chantal
Published: June 2021

Commercial powder bed fusion additive manufacturing systems use re-coaters for the layer-by-layer distribution of powder. Despite the known limitations of re-coaters, there has been relatively little work presented on the possible benefits of alternative powder delivery systems. Here, we reveal a feeding technology that uses vibration to control flow for powder bed additive manufacturing. The capabilities of this approach are illustrated experimentally using two very different powders; a ‘conventional’ gas atomized Ti-6Al-4V powder designed for electron beam additive manufacturing and a water atomized Fe-4 wt.% Ni alloy used in powder metallurgy. Single layer melt trials are shown for the water atomized powder to illustrate the fidelity of the melt tracks in this material. Discrete element modelling is next used to reveal the mechanisms that underpin the observed dependence of feed rate on feeder process parameters and to investigate the potential strengths and limitations of this feeding methodology.
Application of Plastic Wastes in Construction Materials: A Review Using the Concept of Life-Cycle Assessment in the Context of Recent Research for Future Perspectives
Authors: da Silva Tulane Rodrigues , de Azevedo Afonso Rangel Garcez , Cecchin Daiane , Marvila Markssuel Teixeira , Amran Mugahed , Fediuk Roman , Vatin Nikolai , Karelina Maria , Klyuev Sergey , Szelag Maciej
Published: June 2021

The urbanization process contributes to the growth of solid waste generation and causes an increase in environmental impacts and failures in the management of solid waste. The number of dumps is a concern due to the limited implementation and safe disposal of this waste. The interest in sustainable techniques has been growing in relation to waste management, which is largely absorbed by the civil construction sector. This work aimed to review plastic waste, especially polyethylene terephthalate (PET), that can be incorporated with construction materials, such as concrete, mortars, asphalt mixtures, and paving. The use of life-cycle assessment (LCA) is related, as a tool that allows the sustainability of products and processes to be enhanced in the long term. After analyzing the recent literature, it was identified that studies related to plastic wastes in construction materials concentrate sustainability around the alternative destination of waste. Since the plastic waste from different production chains are obtained, it was possible to affirm the need for a broader assessment, such as the LCA, providing greater quantification of data making the alternative processes and products more sustainable. The study contributes to enhance sustainability in alternative building materials through LCA.
Thermodilatometric Study of the Decay of Zeolite-Bearing Building Materials
Authors: Pansini Michele , Cappi Angelo , Monetti Vincenzo , Di Clemente Enrico , de Gennaro Maurizio , D’Amore Marco , Buccino Rosa , Santimone Nuzzi Pierpaolo , de Gennaro Bruno
Published: June 2021

Six zeolite-bearing rocks, often used as building materials, were analyzed by thermodilatometry, together with a rock not bearing zeolites and a plaster covering a containing wall made of zeolite-bearing dimension stones, up to 250 °C. The main results obtained were the following: (i) the zeolite-bearing rocks exhibited very small, if any, positive variation of ΔL/Lo (%) up to about 100 °C, whereas they more or less shrank in the temperature range 100–250 °C (final values ranging from −0.21 to −0.92%); (ii) the rock not bearing zeolites regularly expanded through the whole temperature range, attaining a final value of 0.19%; (iii) the plaster showed a thermodilatometric behavior strongly affected by its water content. Obtained results were interpreted based on plain thermal expansion, shrinkage by dehydration, cation migration and thermal collapse of the zeolitic structure. The decay of the zeolite-bearing building materials was essentially related to: (i) the large differences recorded in the thermodilatometric behavior of the various rocks and the plaster; (ii) the different minerogenetic processes that resulted in the deposition of the various zeolite-bearing rocks.
Macro-Modelling of Laser Micro-Joints for Understanding Joint Strength in Electric Vehicle Battery Interconnects
Authors: Das Abhishek , Beaumont Richard , Masters Iain , Haney Paul
Published: June 2021

Laser micro-welding is increasingly being used to produce electrically conductive joints within a battery module of an automotive battery pack. To understand the joint strength of these laser welds at an early design stage, micro-joints are required to be modelled. Additionally, structural modelling of the battery module along with the electrical interconnects is important for understanding the crash safety of electric vehicles. Fusion zone based micro-modelling of laser welding is not a suitable approach for structural modelling due to the computational inefficiency and the difficulty of integrating with the module model. Instead, a macro-model which computationally efficient and easy to integrate with the structural model can be useful to replicate the behaviour of the laser weld. A macro-modelling approach was adopted in this paper to model the mechanical behaviour of laser micro-weld. The simulations were based on 5 mm diameter circular laser weld and developed from the experimental data for both the lap shear and T-peel tests. This modelling approach was extended to obtain the joint strengths for 3 mm diameter circular seams, 5 mm and 10 mm linear seams. The predicted load–displacement curves showed a close agreement with the test data.
Study on X-ray Induced Two-Dimensional Thermal Shock Waves in Carbon/Phenolic
Authors: Wang Dengwang , Gao Yong , Wang Sheng , Wang Jie , Li Haipeng
Published: June 2021

Carbon/Phenolic (C/P), a typical anisotropic material, is an important component of aerospace and often used to protect the thermodynamic effects of strong X-ray radiation. In this paper, we establish the anisotropic elastic-plastic constitutive model, which is embedded in the in-house code “RAMA” to simulate a two-dimensional thermal shock wave induced by X-ray. Then, we compare the numerical simulation results with the thermal shock wave stress generated by the same strong current electron beam via experiment to verify the correctness of the numerical simulation. Subsequently, we discuss and analyze the rules of thermal shock wave propagation in C/P material by further numerical simulation. The results reveal that the thermal shock wave represents different shapes and mechanisms by the radiation of 1 keV and 3 keV X-rays. The vaporization recoil phenomenon appears as a compression wave under 1 keV X-ray irradiation, and X-ray penetration is caused by thermal deformation under 3 keV X-ray irradiation. The thermal shock wave propagation exhibits two-dimensional characteristics, the energy deposition of 1 keV and 3 keV both decays exponentially, the energy deposition of 1 keV-peak soft X-ray is high, and the deposition depth is shallow, while the energy deposition of 3 keV-peak hard X-ray is low, and the deposition depth is deep. RAMA can successfully realize two-dimensional orthotropic elastoplastic constitutive relation, the corresponding program was designed and checked, and the calculation results for inspection are consistent with the theory. This study has great significance in the evaluation of anisotropic material protection under the radiation of intense X-rays.
4H-SiC Double Trench MOSFET with Split Heterojunction Gate for Improving Switching Characteristics
Authors: Na Jaeyeop , Cheon Jinhee , Kim Kwangsoo
Published: June 2021

In this paper, a novel 4H-SiC split heterojunction gate double trench metal-oxide-semiconductor field-effect transistor (SHG-DTMOS) is proposed to improve switching speed and loss. The device modifies the split gate double trench MOSFET (SG-DTMOS) by changing the N+ polysilicon split gate to the P+ polysilicon split gate. It has two separate P+ shielding regions under the gate to use the P+ split polysilicon gate as a heterojunction body diode and prevent reverse leakage `current. The static and most dynamic characteristics of the SHG-DTMOS are almost like those of the SG-DTMOS. However, the reverse recovery charge is improved by 65.83% and 73.45%, and the switching loss is improved by 54.84% and 44.98%, respectively, compared with the conventional double trench MOSFET (Con-DTMOS) and SG-DTMOS owing to the heterojunction.
Influence of Ti3C2Tx MXene and Surface-Modified Ti3C2Tx MXene Addition on Microstructure and Mechanical Properties of Silicon Carbide Composites Sintered via Spark Plasma Sintering Method
Authors: Petrus Mateusz , Woźniak Jarosław , Cygan Tomasz , Lachowski Artur , Moszczyńska Dorota , Adamczyk-Cieślak Bogusława , Rozmysłowska-Wojciechowska Anita , Wojciechowski Tomasz , Ziemkowska Wanda , Jastrzębska Agnieszka , Olszyna Andrzej
Published: June 2021

This article presents new findings related to the problem of the introduction of MXene phases into the silicon carbide matrix. The addition of MXene phases, as shown by the latest research, can significantly improve the mechanical properties of silicon carbide, including fracture toughness. Low fracture toughness is one of the main disadvantages that significantly limit its use. As a part of the experiment, two series of composites were produced with the addition of 2D-Ti3C2Tx MXene and 2D-Ti3C2Tx surface-modified MXene with the use of the sol-gel method with a mixture of Y2O3/Al2O3 oxides. The composites were obtained with the powder metallurgy technique and sintered with the Spark Plasma Sintering method at 1900 °C. The effect adding MXene phases had on the mechanical properties and microstructure of the produced sinters was investigated. Moreover, the influence of the performed surface modification on changes in the properties of the produced composites was determined. The analysis of the obtained results showed that during sintering, the MXene phases oxidize with the formation of carbon flakes playing the role of reinforcement. The influence of the Y2O3/Al2O3 layer on the structure of carbon flakes and the higher quality of the interface was also demonstrated. This was reflected in the higher mechanical properties of composites with the addition of modified Ti3C2Tx. Composites with 1 wt.% addition of Ti3C2Tx M are characterized with a fracture toughness of 5 MPa × m0.5, which is over 50% higher than in the case of the reference sample and over 15% higher than for the composite with 2.5 wt.% addition of Ti3C2Tx, which showed the highest fracture toughness in this series.
Preparation, Surface Characterization, and Water Resistance of Silicate and Sol-Silicate Inorganic–Organic Hybrid Dispersion Coatings for Wood
Authors: Cheumani Yona Arnaud Maxime , Žigon Jure , Ngueteu Kamlo Alexis , Pavlič Matjaž , Dahle Sebastian , Petrič Marko
Published: June 2021

The purpose of this study was to comparatively investigate the behavior of silicate and sol-silicate coatings non-modified or modified with an organosilane on wood and on wood pre-coated with silica-mineralized primers. Adhesion strength, morphology, and water permeability and related damages were studied to evaluate the possibility of utilizing such inorganic-based coating systems for durable protection of wood without or with relatively cheap and water-borne primers. Potassium silicate and potassium methylsiliconate aqueous solutions and a colloidal silica were used for the preparation of the coatings. The white coating paints were brushed on beech wood substrates at a rate of 220 g·m−2. The coatings exhibited good coverage ability. The pull-off adhesion strength values appeared to be related to pH following a polynomial law. The adhesion strength for the silicate coatings were adequate (above 3 MPa and up to 5 MPa) for wood, whereas the values for the sol-silicates were too low for practical applications. The adhesion values were in general higher for the samples cured in a climate room (23 ± 3 °C and 75 ± 2% relative humidity) than the samples cured in the ambient atmosphere of the laboratory (23 ± 3 °C and 25 ± 5% relative humidity). The presence of microdefects (cracks, holes) was revealed in the coating layers by optical and scanning electron microscopy. The surface roughness parameters assessed by confocal scanning laser microscopy were dependent on the magnification applied for their measurement. The arithmetic average roughness Sa was between 5 µm and 10 µm at magnification 5× and between 2.5 μm and 10 µm at magnification 20×. The maximum peak-to-valley height Sz confirmed the presence of open pores emerging through the coatings. The open pores constitute free pathways for water ingress through the coatings, and could explain the high water absorption of the coatings including the methysiliconate-containing silicate coating and despite the relatively high water contact angle and low wettability exhibited by this sample. The post-application of a hydrophobizing solution containing hexadecyltrimethoxysilane and dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride considerably reduced the water permeability, while application of nanosilica-containing organic primers increased the adhesion for the coatings. Silicate coatings with adhesion great enough and resistance against water damages can be generated on wood even without a primer using low silica-to-alkali ratio binders and an organosilane additive. The sol-silicate coatings appear to be applicable only with a primer. The improvement of the paint formulations to control the formation of microcracks and open pores could be useful to reduce the liquid water permeability and increase durability. Otherwise, the application of a hydrophobizing treatment can be used for this purpose.
Balancing Strength and Ductility in Al Matrix Composites Reinforced by Few-Layered MoS2 through In-Situ Formation of Interfacial Al12Mo
Authors: Fan Lewen , Yang Lizhuang , Zhao Dongdong , Ma Liying , He Chunnian , He Fang , Shi Chunsheng , Sha Junwei , Zhao Naiqin
Published: June 2021

In this work, few-layered MoS2 (FLM) nanosheet-reinforced Al matrix composites are developed through powder metallurgy and hot extrusion. The microstructure, mechanical properties, and strengthening mechanisms have been systematically investigated. It is found that Al12Mo and Al2S3 can be formed in-situ during the sintering process, resulting in the improvement of interfacial bonding between FLM and Al matrix. With 1.5 wt.% of FLM addition, an improved tensile strength of 234 MPa with a high elongation of 17% can be obtained. Moreover, the strengthening mechanisms are also demonstrated to be grain refinement, dislocation strengthening, and load transfer, and the calculation indicates that load transfer is the main contribution factor. This work will inspire more new designs of metal matrix composites with balanced strength and ductility.
Formation of Iron Sulfides on Carbon Steel in a Specific Cement Grout Designed for Radioactive Waste Repository and Associated Corrosion Mechanisms
Authors: Robineau Mathieu , Deydier Valérie , Crusset Didier , Bellefleur Alexandre , Neff Delphine , Vega Enrique , Sabot René , Jeannin Marc , Refait Philippe
Published: June 2021

Carbon steel coupons were buried in a specific low-pH cement grout designed for radioactive waste disposal and left 6 months in anoxic conditions at 80 °C. The corrosion product layers were analyzed by µ-Raman spectroscopy, XRD, and SEM. They proved to be mainly composed of iron sulfides, with magnetite as a minor phase, mixed with components of the grout. Average corrosion rates were estimated by weight loss measurements between 3 and 6 µm yr−1. Corrosion profiles revealed local degradations with a depth up to 10 µm. It is assumed that the heterogeneity of the corrosion product layer, mainly composed of conductive compounds (FeS, Fe3S4, and Fe3O4), promotes the persistence of corrosion cells that may lead to locally aggravated degradations of the metal. New cement grouts, characterized by a slightly higher pH and a lower sulfide concentration, should then be designed for the considered application.
Effectiveness of Silanization and Plasma Treatment in the Improvement of Selected Flax Fibers’ Properties
Authors: Gieparda Weronika , Rojewski Szymon , Różańska Wanda
Published: June 2021

The study investigated the effectiveness of the combination of chemical and physical methods of natural fibers’ modification. The long flax fibers were subjected to various types of modification. These were silanization, plasma modification and a combination of these methods. For the silanization process, two types of silanes were used: amino- and vinylsilane. The application of structurally different compounds allowed us to acquire knowledge about the effect of the modifier structure on its properties. Various properties of flax fibers were investigated, comparing the results before and after different modification processes. The flammability of prepared samples were tested by pyrolysis combustion flow calorimeter (PCFC). In the effect of the natural fibers’ modifications, flammability was reduced even by 30%. The thermal stability of modified fibers increased. The FTIR tests of the gases released during thermal degradation of the tested fibers allowed us to determine the important compounds and prove a lower degree of flax-fiber decomposition after modification. Flax fibers were also tested to evaluate their physical properties (linear mass, average diameter, aspect ratio and hygroscopicity). Changes in surface morphology were observed by scanning electron microscope (SEM). The properties of natural fibers improved significantly, thus contributing to an increase in their suitability for the use in composites.
Time-Resolved PIV Measurements and Turbulence Characteristics of Flow Inside an Open-Cell Metal Foam
Authors: Kim Youngwoo , Moon Chanhee , Nematollahi Omid , Kim Hyun Dong , Kim Kyung Chun
Published: June 2021

Open-cell metal foams are porous medium for thermo-fluidic systems. However, their complex geometry makes it difficult to perform time-resolved (TR) measurements inside them. In this study, a TR particle image velocimetry (PIV) method is introduced for use inside open-cell metal foam structures. Stereolithography 3D printing methods and conventional post-processing methods cannot be applied to metal foam structures; therefore, PolyJet 3D printing and post-processing methods were employed to fabricate a transparent metal foam replica. The key to obtaining acceptable transparency in this method is the complete removal of the support material from the printing surfaces. The flow characteristics inside a 10-pore-per-inch (PPI) metal foam were analyzed in which porosity is 0.92 while laminar flow condition is applied to inlet. The flow inside the foam replica is randomly divided and combined by the interconnected pore network. Robust crosswise motion occurs inside foam with approximately 23% bulk speed. Strong influence on transverse motion by metal foam is evident. In addition, span-wise vorticity evolution is similar to the integral time length scale of the stream-wise center plane. The span-wise vorticity fluctuation through the foam arrangement is presented. It is believed that this turbulent characteristic is caused by the interaction of jets that have different flow directions inside the metal foam structure. The finite-time Lyapunov exponent method is employed to visualize the vortex ridges. Fluctuating attracting and repelling material lines are expected to enhance the heat and mass transfer. The results presented in this study could be useful for understanding the flow characteristics inside metal foams.
Investigation of Hydrothermally Stressed Silicone Rubber/Silica Micro and Nanocomposite for the Coating High Voltage Insulation Applications
Authors: Faiza  , Khattak Abraiz , Butt Safi Ullah , Imran Kashif , Ulasyar Abasin , Ali Asghar , Khan Zuhair Subhani , Mahmood Azhar , Ullah Nasim , Alahmadi Ahmad Aziz , Khan Adam
Published: June 2021

Silicone rubber is a promising insulating material that has been performing well for different insulating and dielectric applications. However, in outdoor applications, environmental stresses cause structural and surface degradations that diminish its insulating properties. This effect of degradation can be reduced with the addition of a suitable filler to the polymer chains. For the investigation of structural changes and hydrophobicity four different systems were fabricated, including neat silicone rubber, a micro composite (with 15% micro-silica filler), and nanocomposites (with 2.5% and 5% nanosilica filler) by subjecting them to various hydrothermal conditions. In general, remarkable results were obtained by the addition of fillers. However, nanocomposites showed the best resistance against the applied stresses. In comparison to neat silicone rubber, the stability of the structure and hydrophobic behavior was better for micro-silica, which was further enhanced in the case of nanocomposites. The inclusion of 5% nanosilica showed the best results before and after applying aging conditions.
Geopolymer Foams—Will They Ever Become a Viable Alternative to Popular Insulation Materials?—A Critical Opinion
Authors: Łach Michał
Published: June 2021

Over the last several years, there has been a large increase in interest in geopolymer materials, which are usually produced from waste materials, and their applications. The possibilities of application of geopolymers seem to be unlimited, and they are used in almost all fields of technology. Their use as insulation materials appears promising due to their complete nonflammability and excellent strength. However, one limitation is their complex manufacturing process and lack of stability of the obtained geopolymer foams as well as difficulties in achieving such good insulation properties possessed by polyurethane foams, polystyrene, and wool. Hundreds of studies have already been performed on insulating geopolymer foams and various types of foaming agents, and their authors reported that foamed insulating geopolymers had a density starting from 200 kg/m3 and thermal conductivity from 0.04 W/mK. However, the repeatability of the obtained results on an industrial scale is questionable. It is still a challenge to obtain a geopolymer material with comparable properties as conventional insulation materials and to overcome the barriers associated with the successful implementation of geopolymer material as insulation in buildings and other applications on a mass scale. This paper provides a comprehensive review of the methods used for the production of foamed geopolymers and the best parameters obtained, as well as a summary of the most important information reported in the scientific literature. It also presents the results of a critical analysis of the feasibility of implementing this technology for mass deployment. In addition, the problems and limitations that are most often encountered with the implementation of geopolymer technology are discussed.
Modified Carboxymethylcellulose-Based Scaffolds as New Potential Ecofriendly Superplasticizers with a Retardant Effect for Mortar: From the Synthesis to the Application
Authors: Capacchione Clotilde , Partschefeld Stephan , Osburg Andrea , Gliubizzi Rocco , Gaeta Carmine
Published: June 2021

This article is focused on the research and development of new cellulose ether derivatives as innovative superplasticizers for mortar systems. Several synthetic strategies have been pursued to obtain new compounds to study their properties on cementitious systems as new bio-based additives. The new water-soluble admixtures were synthesized using a complex carboxymethylcellulose-based backbone that was first hydrolyzed and then sulfo-ethylated in the presence of sodium vinyl sulphonate. Starting with a complex biopolymer that is widely known as a thickening agent was very challenging. Only by varying the hydrolysis times and temperatures of the reactions was achieved the aimed goal. The obtained derivatives showed different molecular weight (Mw) and anionic charges on their backbones. An improvement in shear stress and dynamic viscosity values of CEM II 42.5R cement was observed with the samples obtained with a longer time of higher temperature hydrolysis and sulfo-ethylation. Investigations into the chemical nature of the pore solution, calorimetric studies and adsorption experiments clearly showed the ability of carboxymethyl cellulose superplasticizer (CMC SP) to interact with cement grains and influence hydration processes within a 48-h time window, causing a delay in hydration reactions in the samples. The fluidity of the cementitious matrices was ascertained through slump test and preliminary studies of mechanical and flexural strength of the hardened mortar formulated with the new ecological additives yielded values in terms of mechanical properties. Finally, the computed tomography (CT) images completed the investigation of the pore network structure of hardened specimens, highlighting their promising structure porosity.
Effects of Geometric and Crystallographic Factors on the Reliability of Al/Si Vertically Cracked Nanofilm/Substrate Systems
Authors: Shim Jee S. , Go Dong H. , Beom Hyeon G.
Published: June 2021

In this study, tensile tests on aluminum/silicon vertically cracked nanofilm/substrate systems were performed using atomistic simulations. Various crystallographic orientations and thicknesses of the aluminum nanofilms were considered to analyze the effects of these factors on the reliability of the nanofilm/substrate systems. The results show that systems with some specific crystallographic orientations have lower reliability compared to the other orientations because of the penetration of the vertical crack into the silicon substrate. This penetration phenomenon occurring in a specific model is related to a high coincidence of atomic matching between the interfaces in the model. This high coincidence leads to a tendency of the interface to maintain a coherent form in which the outermost silicon atoms of the substrate that are bonded to the aluminum nanofilm tend to stick with the aluminum atoms under tensile loads. This phenomenon was verified by interface energy calculations in the simulation models.
Enhanced BDNF Actions Following Acute Hypoxia Facilitate HIF-1α-Dependent Upregulation of Cav3-T-Type Ca2+ Channels in Rat Cardiomyocytes
Authors: Morishima Masaki , Fujita Takafumi , Osagawa Satoshi , Kubota Hiroshi , Ono Katsushige
Published: June 2021

Brain-derived neurotrophic factor (BDNF) has recently been recognized as a cardiovascular regulator particularly in the diseased condition, including coronary artery disease, heart failure, cardiomyopathy, and hypertension. Here, we investigate the role of BDNF on the T-type Ca2+ channel, Cav3.1 and Cav3.2, in rat neonatal cardiomyocytes exposed to normoxia (21% O2) and acute hypoxia (1% O2) in vitro for up to 3 h. The exposure of cardiomyocytes to hypoxia (1 h, 3 h) caused a significant upregulation of the mRNAs for hypoxia-inducible factor 1α (Hif1α), Cav3.1, Cav3.2 and Bdnf, but not tropomyosin-related kinase receptor B (TrkB). The upregulation of Cav3.1 and Cav3.2 caused by hypoxia was completely halted by small interfering RNA (siRNA) targeting Hif1a (Hif1a-siRNA) or Bdnf (Bdnf-siRNA). Immunocytochemical staining data revealed a distinct upregulation of Cav3.1- and Cav3.2-proteins caused by hypoxia in cardiomyocytes, which was markedly suppressed by Bdnf-siRNA. These results unveiled a novel regulatory action of BDNF on the T-type Ca2+ channels expression through the HIF-1α-dependent pathway in cardiomyocytes.
Compact Full Ka-Band Waveguide Directional Coupler Based on Rectangular Aperture Array with Stairs
Authors: Deng Xida , Dong Ge , Dai Xuan , Deng Jinxiang
Published: June 2021

This article presents a compact 3 dB waveguide directional coupler with full waveguide bandwidth. It consists of a pair of rectangular waveguides with stairs structures in the coupling region. The waveguides are placed parallel to each other along their broad wall, which has a rectangular aperture array. The compact size, broad bandwidth, good in-band coupling flatness, and good return loss are achieved by using the proposed structure. For verification purposes, a prototype of the proposed coupler was designed, manufactured, and measured. The experimental results show that over the full waveguide bandwidth a return loss of input port better than 17.46 dB, coupling strength varying between −2.74 dB and −3.80 dB, power-split unbalance within 0.76 dB, and an isolation better than 20.82 dB were obtained. The length of the coupling region was only 15.82 mm.
Cystic Fibrosis Human Organs-on-a-Chip
Authors: Ogden Herbert Luke , Kim Hoyeol , Wikenheiser-Brokamp Kathryn A. , Naren Anjaparavanda P. , Mun Kyu Shik
Published: June 2021

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most epithelial cells. Major clinical features of CF include respiratory failure, pancreatic exocrine insufficiency, and intestinal disease. Many CF animal models have been generated, but some models fail to fully capture the phenotypic manifestations of human CF disease. Other models that better capture the key characteristics of the human CF phenotype are cost prohibitive or require special care to maintain. Important differences have been reported between the pathophysiology seen in human CF patients and in animal models. These limitations present significant limitations to translational research. This review outlines the study of CF using patient-derived organs-on-a-chip to overcome some of these limitations. Recently developed microfluidic-based organs-on-a-chip provide a human experimental model that allows researchers to manipulate environmental factors and mimic in vivo conditions. These chips may be scaled to support pharmaceutical studies and may also be used to study organ systems and human disease. The use of these chips in CF discovery science enables researchers to avoid the barriers inherent in animal models and promote the advancement of personalized medicine.
A Lubricating Oil Condition Monitoring System Based on Wear Particle Kinematic Analysis in Microfluid for Intelligent Aeroengine
Authors: Liu Zhenzhen , Liu Yan , Zuo Hongfu , Wang Han , Fei Hang
Published: June 2021

Lubricating oil monitoring technology is a commonly used method in aeroengine condition monitoring, which includes particle counting technology, as well as spectral and ferrography technology in offline monitoring. However, these technologies only analyze the characteristics of wear particles and rely on physical and chemical analysis techniques to monitor the oil quality. In order to further advance offline monitoring technology, this paper explores the potential role of differences in wear particle kinematic characteristics in recognizing changes in wear particle diameter and oil viscosity. Firstly, a kinematic force analysis of the wear particles in the microfluid was carried out. Accordingly, a microfluidic channel conducive to observing the movement characteristics of particles was designed. Then, the wear particle kinematic analysis system (WKAS) was designed and fabricated. Secondly, a real-time tracking velocity measurement algorithm was developed by using the Gaussian mixture model (GMM) and the blob-tracking algorithm. Lastly, the WKAS was applied to a pin–disc tester, and the experimental results show that there is a corresponding relationship between the velocity of the particles and their diameter and the oil viscosity. Therefore, WKAS provides a new research idea for intelligent aeroengine lubricating oil monitoring technology. Future work is needed to establish a quantitative relationship between wear particle velocity and particle diameter, density, and oil viscosity.
Adapting a Parental Support App to Promote Healthy Diet and Physical Activity Behaviors (MINISTOP) for a Multi-Ethnic Setting: A Qualitative Study on the Needs and Preferences of Parents and Nurses within Swedish Child Health Care
Authors: Alexandrou Christina , Müssener Ulrika , Thomas Kristin , Henriksson Hanna , Löf Marie
Published: June 2021

Early efforts for prevention of childhood overweight and obesity are needed. In order to adapt an app promoting healthy diet and physical activity behaviors in children (MINISTOP 1.0) for multi-ethnic communities, we explored: (1) needs and concerns among Somali-, Arabic-, and Swedish-speaking parents in terms of supporting healthy diet and activity behaviors in their children; (2) nurses’ perceptions of parental needs and concerns in relation to diet and physical activity behaviors; and (3) how the features and content of the MINISTOP 1.0 app could be refined to better support health behaviors in children, among both parents and nurses. Focus groups with Somali-, Arabic-, and Swedish-speaking parents (n = 15), and individual interviews with nurses (n = 15) were conducted. Parents expressed several challenges in supporting children’s health behaviors, the need for a tailored app, and alternative ways of accessing the content (audio/video). Nurses emphasized the need of supporting parents early, and the value of a shared platform in different languages, to facilitate communication. This study contributes valuable insights about parental needs and relevant adaptations to a parental support app, such as addition of audio/video files for increased accessibility. This adapted app version—MINISTOP 2.0, can be useful for childhood obesity prevention in multi-ethnic communities.
Mimicking Pathogens to Augment the Potency of Liposomal Cancer Vaccines
Authors: Nijen Twilhaar Maarten K. , Czentner Lucas , van Nostrum Cornelus F. , Storm Gert , den Haan Joke M. M.
Published: June 2021

Liposomes have emerged as interesting vehicles in cancer vaccination strategies as their composition enables the inclusion of both hydrophilic and hydrophobic antigens and adjuvants. In addition, liposomes can be decorated with targeting moieties to further resemble pathogenic particles that allow for better engagement with the immune system. However, so far liposomal cancer vaccines have not yet reached their full potential in the clinic. In this review, we summarize recent preclinical studies on liposomal cancer vaccines. We describe the basic ingredients for liposomal cancer vaccines, tumor antigens, and adjuvants, and how their combined inclusion together with targeting moieties potentially derived from pathogens can enhance vaccine immunogenicity. We discuss newly identified antigen-presenting cells in humans and mice that pose as promising targets for cancer vaccines. The lessons learned from these preclinical studies can be applied to enhance the efficacy of liposomal cancer vaccination in the clinic.
A Novel Curcumin-Mycophenolic Acid Conjugate Inhibited Hyperproliferation of Tumor Necrosis Factor-Alpha-Induced Human Keratinocyte Cells
Authors: Yuyun Yonelian , Ratnatilaka Na Bhuket Pahweenvaj , Supasena Wiwat , Suwattananuruk Piyapan , Praengam Kemika , Vajragupta Opa , Muangnoi Chawanphat , Rojsitthisak Pornchai
Published: June 2021

Curcumin (CUR) has been used as adjuvant therapy for therapeutic application in the treatment of psoriasis through several mechanisms of action. Due to the poor oral bioavailability of CUR, several approaches have been developed to overcome the limitations of CUR, including the prodrug strategy. In this study, CUR was esterified with mycophenolic acid (MPA) as a novel conjugate prodrug. The MPA-CUR conjugate was structurally elucidated using FT-IR, 1H-NMR, 13C-NMR, and MS techniques. Bioavailable fractions (BFs) across Caco-2 cells of CUR, MPA, and MPA-CUR were collected for further biological activity evaluation representing an in vitro cellular transport model for oral administration. The antipsoriatic effect of the BFs was determined using antiproliferation and anti-inflammation assays against hyperproliferation of tumor necrosis factor-alpha (TNF-α)-induced human keratinocytes (HaCaT). The BF of MPA-CUR provided better antiproliferation than that of CUR (p < 0.001). The enhanced hyperproliferation suppression of the BF of MPA-CUR resulted from the reduction of several inflammatory cytokines, including IL-6, IL-8, and IL-1β. The molecular mechanisms of anti-inflammatory activity were mediated by an attenuated signaling cascade of MAPKs protein, i.e., p38, ERK, and JNK. Our results present evidence for the MPA-CUR conjugate as a promising therapeutic agent for treating psoriasis by antiproliferative and anti-inflammatory actions.
Electrically Triggered Drug Delivery from Novel Electrospun Poly(Lactic Acid)/Graphene Oxide/Quercetin Fibrous Scaffolds for Wound Dressing Applications
Authors: Croitoru Alexa-Maria , Karaçelebi Yasin , Saatcioglu Elif , Altan Eray , Ulag Songul , Aydoğan Huseyin Kıvanc , Sahin Ali , Motelica Ludmila , Oprea Ovidiu , Tihauan Bianca-Maria , Popescu Roxana-Cristina , Savu Diana , Trusca Roxana , Ficai Denisa , Gunduz Oguzhan , Ficai Anton
Published: June 2021

The novel controlled and localized delivery of drug molecules to target tissues using an external electric stimulus makes electro-responsive drug delivery systems both feasible and desirable, as well as entailing a reduction in the side effects. Novel micro-scaffold matrices were designed based on poly(lactic acid) (PLA) and graphene oxide (GO) via electrospinning. Quercetin (Q), a natural flavonoid, was loaded into the fiber matrices in order to investigate the potential as a model drug for wound dressing applications. The physico-chemical properties, electrical triggering capacity, antimicrobial assay and biocompatibility were also investigated. The newly fabricated PLA/GO/Q scaffolds showed uniform and smooth surface morphologies, without any beads, and with diameters ranging from 1107 nm (10%PLA/0.1GO/Q) to 1243 nm (10%PLA). The in vitro release tests of Q from the scaffolds showed that Q can be released much faster (up to 8640 times) when an appropriate electric field is applied compared to traditional drug-release approaches. For instance, 10 s of electric stimulation is enough to ensure the full delivery of the loaded Q from the 10%PLA/1%GO/Q microfiber scaffold at both 10 Hz and at 50 Hz. The antimicrobial tests showed the inhibition of bacterial film growth. Certainly, these materials could be loaded with more potent agents for anti-cancer, anti-infection, and anti-osteoporotic therapies. The L929 fibroblast cells cultured on these scaffolds were distributed homogeneously on the scaffolds, and the highest viability value of 82.3% was obtained for the 10%PLA/0.5%GO/Q microfiber scaffold. Moreover, the addition of Q in the PLA/GO matrix stimulated the production of IL-6 at 24 h, which could be linked to an acute inflammatory response in the exposed fibroblast cells, as a potential effect of wound healing. As a general conclusion, these results demonstrate the possibility of developing graphene oxide-based supports for the electrically triggered delivery of biological active agents, with the delivery rate being externally controlled in order to ensure personalized release.