bluuebunny/crossref_metadata_2025 huggingface dataset:
Chikungunya Beyond the Tropics: Where and When Do We Expect Disease Transmission in Europe?
Authors: Tjaden Nils Benjamin , Cheng Yanchao , Beierkuhnlein Carl , Thomas Stephanie Margarete
Published: May 2021

Chikungunya virus disease (chikungunya) is a mosquito-borne infectious disease reported in at least 50 countries, mostly in the tropics. It has spread around the globe within the last two decades, with local outbreaks in Europe. The vector mosquito Aedes albopictus (Diptera, Culicidae) has already widely established itself in southern Europe and is spreading towards central parts of the continent. Public health authorities and policymakers need to be informed about where and when a chikungunya transmission is likely to take place. Here, we adapted a previously published global ecological niche model (ENM) by including only non-tropical chikungunya occurrence records and selecting bioclimatic variables that can reflect the temperate and sub-tropical conditions in Europe with greater accuracy. Additionally, we applied an epidemiological model to capture the temporal outbreak risk of chikungunya in six selected European cities. Overall, the non-tropical ENM captures all the previous outbreaks in Europe, whereas the global ENM had underestimated the risk. Highly suitable areas are more widespread than previously assumed. They are found in coastal areas of the Mediterranean Sea, in the western part of the Iberian Peninsula, and in Atlantic coastal areas of France. Under a worst-case scenario, even large areas of western Germany and the Benelux states are considered potential areas of transmission. For the six selected European cities, June–September (the 22th–38th week) is the most vulnerable time period, with the maximum continuous duration of a possible transmission period lasting up to 93 days (Ravenna, Italy).
Insights into SARS-CoV-2 Persistence and Its Relevance
Authors: Desimmie Belete A. , Raru Yonas Y. , Awadh Hesham M. , He Peimei , Teka Samson , Willenburg Kara S.
Published: May 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), continues to wreak havoc, threatening the public health services and imposing economic collapse worldwide. Tailoring public health responses to the SARS-CoV-2 pandemic depends on understanding the mechanism of viral replication, disease pathogenesis, accurately identifying acute infections, and mapping the spreading risk of hotspots across the globe. However, effective identification and isolation of persons with asymptomatic and mild SARS-CoV-2 infections remain the major obstacles to efforts in controlling the SARS-CoV-2 spread and hence the pandemic. Understanding the mechanism of persistent viral shedding, reinfection, and the post-acute sequalae of SARS-CoV-2 infection (PASC) is crucial in our efforts to combat the pandemic and provide better care and rehabilitation to survivors. Here, we present a living literature review (January 2020 through 15 March 2021) on SARS-CoV-2 viral persistence, reinfection, and PASC. We also highlight potential areas of research to uncover putative links between viral persistence, intra-host evolution, host immune status, and protective immunity to guide and direct future basic science and clinical research priorities.
Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?
Authors: Salahong Thanarat , Schwartz Christian , Sungthong Rungroch
Published: May 2021

AIDS first emerged decades ago; however, its cure, i.e., eliminating all virus sources, is still unachievable. A critical burden of AIDS therapy is the evasive nature of HIV-1 in face of host immune responses, the so-called “latency.” Recently, a promising approach, the “Shock and Kill” strategy, was proposed to eliminate latently HIV-1-infected cell reservoirs. The “Shock and Kill” concept involves two crucial steps: HIV-1 reactivation from its latency stage using a latency-reversing agent (LRA) followed by host immune responses to destroy HIV-1-infected cells in combination with reinforced antiretroviral therapy to kill the progeny virus. Hence, a key challenge is to search for optimal LRAs. Looking at epigenetics of HIV-1 infection, researchers proved that some bromodomains and extra-terminal motif protein inhibitors (BETis) are able to reactivate HIV-1 from latency. However, to date, only a few BETis have shown HIV-1-reactivating functions, and none of them have yet been approved for clinical trial. In this review, we aim to demonstrate the epigenetic roles of BETis in HIV-1 infection and HIV-1-related immune responses. Possible future applications of BETis and their HIV-1-reactivating properties are summarized and discussed.
Novel Ampeloviruses Infecting Cassava in Central Africa and the South-West Indian Ocean Islands
Authors: Kwibuka Yves , Bisimwa Espoir , Blouin Arnaud G. , Bragard Claude , Candresse Thierry , Faure Chantal , Filloux Denis , Lett Jean-Michel , Maclot François , Marais Armelle , Ravelomanantsoa Santatra , Shakir Sara , Vanderschuren Hervé , Massart Sébastien
Published: May 2021

Cassava is one of the most important staple crops in Africa and its production is seriously damaged by viral diseases. In this study, we identify for the first time and characterize the genome organization of novel ampeloviruses infecting cassava plants in diverse geographical locations using three high-throughput sequencing protocols [Virion-Associated Nucleotide Acid (VANA), dsRNA and total RNA], and we provide a first analysis of the diversity of these agents and of the evolutionary forces acting on them. Thirteen new Closteroviridae isolates were characterized in field-grown cassava plants from the Democratic Republic of Congo (DR Congo), Madagascar, Mayotte, and Reunion islands. The analysis of the sequences of the corresponding contigs (ranging between 10,417 and 13,752 nucleotides in length) revealed seven open reading frames. The replication-associated polyproteins have three expected functional domains: methyltransferase, helicase, and RNA-dependent RNA polymerase (RdRp). Additional open reading frames code for a small transmembrane protein, a heat-shock protein 70 homolog (HSP70h), a heat shock protein 90 homolog (HSP90h), and a major and a minor coat protein (CP and CPd respectively). Defective genomic variants were also identified in some cassava accessions originating from Madagascar and Reunion. The isolates were found to belong to two species tentatively named Manihot esculenta-associated virus 1 and 2 (MEaV-1 and MEaV-2). Phylogenetic analyses showed that MEaV-1 and MEaV-2 belong to the genus Ampelovirus, in particular to its subgroup II. MEaV-1 was found in all of the countries of study, while MEaV-2 was only detected in Madagascar and Mayotte. Recombination analysis provided evidence of intraspecies recombination occurring between the isolates from Madagascar and Mayotte. No clear association with visual symptoms in the cassava host could be identified.
Hepatitis B Virus-Related Cryoglobulinemic Vasculitis: Review of the Literature and Long-Term Follow-Up Analysis of 18 Patients Treated with Nucleos(t)ide Analogues from the Italian Study Group of Cryoglobulinemia (GISC)
Authors: Mazzaro Cesare , Dal Maso Luigino , Gragnani Laura , Visentini Marcella , Saccardo Francesco , Filippini Davide , Andreone Pietro , Zignego Anna , Gattei Valter , Monti Giuseppe , Galli Massimo , Quartuccio Luca
Published: May 2021

Hepatitis B virus (HBV) chronic infection causes progressive liver damage, although about 20% of patients develop extrahepatic manifestations such as cryoglobulinemic vasculitis (CV). Clinical manifestations range from mild to moderate (purpura, asthenia, arthralgia) to severe (leg ulcers, peripheral neuropathy, glomerulonephritis, non-Hodgkin lymphoma). A comprehensive review of therapeutic options for HBV-related CV is lacking. Nucleos(t)ide analogues (NA) suppress HBV replication in 90–100% of cases and induce clinical response in most patients with mild-to-moderate CV. Plasma exchange can be performed in patients with severe CV and should be considered in severe or life-threatening cases combined with high doses of corticosteroids and antiviral treatment. A cautious use of rituximab can be considered only in association with NA treatment in refractory cases. A review of the literature and an analysis of data collected by six centers of the Italian Group for the Study of Cryoglobulinemia on 18 HBV-CV nucleotide/nucleoside analogues (NAs)-treated patients were carried out.
Genomic Analysis of a Novel Phage Infecting the Turkey Pathogen Escherichia coli APEC O78 and Its Endolysin Activity
Authors: Deng Sangsang , Xu Qiang , Fu Yajuan , Liang Leiqin , Wu Yan , Peng Fang , Gao Meiying
Published: May 2021

Due to the increasing spread of multidrug-resistant (MDR) bacteria, phage therapy is considered one of the most promising methods for addressing MDR bacteria. Escherichia coli lives symbiotically in the intestines of humans and some animals, and most strains are beneficial in terms of maintaining a healthy digestive tract. However, some E. coli strains can cause serious zoonotic diseases, including diarrhea, pneumonia, urinary tract infections, and hemolytic uremic syndrome. In this study, we characterized a newly isolated Myoviridae phage, vB_EcoM_APEC. The phage vB_EcoM_APEC was able to infect E. coli APEC O78, which is the most common MDR E. coli serotype in turkeys. Additionally, the phage’s host range included Klebsiella pneumoniae and other E. coli strains. The genome of phage vB_EcoM_APEC (GenBank accession number MT664721) was 35,832 bp in length, with 52 putative open reading frames (ORFs) and a GC content of 41.3%. The genome of vB_EcoM_APEC exhibited low similarity (79.1% identity and 4.0% coverage) to the genome of Acinetobacter phage vB_AbaM_IME284 (GenBank no. MH853787.1) according to the nucleotide Basic Local Alignment Search Tool (BLASTn). Phylogenetic analysis revealed that vB_EcoM_APEC was a novel phage, and its genome sequence showed low similarity to other available phage genomes. Gene annotation indicated that the protein encoded by orf11 was an endolysin designated as LysO78, which exhibited 64.7% identity (91.0% coverage) with the putative endolysin of Acinetobacter baumannii phage vB_AbaM_B9. The LysO78 protein belongs to glycoside hydrolase family 19, and was described as being a chitinase class I protein. LysO78 is a helical protein with 12 α-helices containing a large domain and a small domain in terms of the predicted three-dimensional structure. The results of site-directed mutagenesis indicated that LysO78 contained the catalytic residues E54 and E64. The purified endolysin exhibited broad-spectrum bacteriolytic activity against Gram-negative strains, including the genera Klebsiella, Salmonella, Shigella, Burkholderia, Yersinia, and Pseudomonas, as well as the species Chitinimonas arctica, E. coli, Ralstonia solanacearum, and A. baumannii. An enzymatic assay showed that LysO78 had highly lytic peptidoglycan hydrolases activity (64,620,000 units/mg) against E. coli APEC O78, and that LysO78 had lytic activity in the temperature range of 4–85 °C, with an optimal temperature of 28 °C and optimal pH of 8.0, and was active at pH 3.0–12.0. Overall, the results suggested that LysO78 might be a promising therapeutic agent for controlling MDR E. coli APEC O78 and nosocomial infections caused by multidrug-resistant bacteria.
Comparative Proteomic Profiling: Cellular Metabolisms Are Mainly Affected in Senecavirus A-Inoculated Cells at an Early Stage of Infection
Authors: Liu Fuxiao , Ni Bo , Wei Rong
Published: May 2021

Senecavirus A (SVA), also known as Seneca Valley virus, belongs to the genus Senecavirus in the family Picornaviridae. SVA can cause vesicular disease and epidemic transient neonatal losses in pigs. This virus efficiently propagates in some non-pig-derived cells, like the baby hamster kidney (BHK) cell line and its derivate (BSR-T7/5). Conventionally, a few proteins or only one protein is selected for exploiting a given mechanism concerning cellular regulation after SVA infection in vitro. Proteomics plays a vital role in the analysis of protein profiling, protein-protein interactions, and protein-directed metabolisms, among others. Tandem mass tag-labeled liquid chromatography-tandem mass spectrometry combined with the parallel reaction monitoring technique is increasingly used for proteomic research. In this study, this combined method was used to uncover separately proteomic profiles of SVA- and non-infected BSR-T7/5 cells. Furthermore, both proteomic profiles were compared with each other. The proteomic profiling showed that a total of 361 differentially expressed proteins were identified, out of which, 305 and 56 were upregulated and downregulated in SVA-infected cells at 12 h post-inoculation, respectively. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analyses showed that cellular metabolisms were affected mainly in SVA-inoculated cells at an early stage of infection. Therefore, an integrated metabolic atlas remains to be explored via metabolomic methods.
Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines
Authors: Lu Lantian , Duong Viet Tram , Shalash Ahmed O. , Skwarczynski Mariusz , Toth Istvan
Published: May 2021

The production of subunit nanovaccines relies heavily on the development of a vaccine delivery system that is safe and efficient at delivering antigens to the target site. Nanoparticles have been extensively investigated for vaccine delivery over the years, as they often possess self-adjuvanting properties. The conjugation of antigens to nanoparticles by covalent bonds ensures co-delivery of these components to the same subset of immune cells in order to trigger the desired immune responses. Herein, we review covalent conjugation strategies for grafting protein or peptide antigens onto other molecules or nanoparticles to obtain subunit nanovaccines. We also discuss the advantages of chemical conjugation in developing these vaccines.
Immunogenicity and Safety of Inactivated Sabin-Strain Polio Vaccine “PoliovacSin”: Clinical Trials Phase I and II
Authors: Piniaeva Anastasia , Ignatyev Georgy , Kozlovskaya Liubov , Ivin Yury , Kovpak Anastasia , Ivanov Alexander , Shishova Anna , Antonova Liliia , Khapchaev Yusuf , Feldblium Irina , Ivanova Olga , Siniugina Aleksandra , Ishmukhametov Aydar
Published: May 2021

Global polio eradication requires both safe and effective vaccines, and safe production processes. Sabin oral poliomyelitis vaccine (OPV) strains can evolve to virulent viruses and result in poliomyelitis outbreaks, and conventional inactivated poliomyelitis vaccine (Salk-IPV) production includes accumulation of large stocks of neurovirulent wild polioviruses. Therefore, IPV based on attenuated OPV strains seems a viable option. To increase the global supply of affordable inactivated vaccine in the still not-polio free world we developed an IPV made from the Sabin strains–PoliovacSin. Clinical trials included participants 18–60 years of age. A phase I single-center, randomized, double-blind placebo-controlled clinical trial included 60 participants, who received one dose of PoliovacSin or Placebo. A phase II multicenter, randomized, double-blind, comparative clinical trial included 200 participants, who received one dose of PoliovacSin or Imovax Polio. All vaccinations were well tolerated, and PoliovacSin had a comparable safety profile to the Placebo or the reference Imovax Polio preparations. A significant increase in neutralizing antibody levels to polioviruses types 1–3 (Sabin and wild) was observed in PoliovacSin and Imovax Polio vaccinated groups. Therefore, clinical trials confirmed good tolerability, low reactogenicity, and high safety profile of the PoliovacSin and its pronounced immunogenic properties. The preparation was approved for clinical trials involving infants.
Global Prevalence and Drivers of Dental Students’ COVID-19 Vaccine Hesitancy
Authors: Riad Abanoub , Abdulqader Huthaifa , Morgado Mariana , Domnori Silvi , Koščík Michal , Mendes José , Klugar Miloslav , Kateeb Elham ,   on behalf of IADS-SCORE
Published: May 2021

Background: Acceleration of mass vaccination strategies is the only pathway to overcome the COVID-19 pandemic. Healthcare professionals and students have a key role in shaping public opinion about vaccines. This study aimed to evaluate the attitudes of dental students globally towards COVID-19 vaccines and explore the potential drivers for students’ acceptance levels. Methods: A global cross-sectional study was carried out in February 2021 using an online questionnaire. The study was liaised by the scientific committee of the International Association of Dental Students (IADS), and data were collected through the national and local coordinators of IADS member organizations. The dependent variable was the willingness to take the COVID-19 vaccine, and the independent variables included demographic characteristics, COVID-19-related experience, and the drivers of COVID-19 vaccine-related attitude suggested by the WHO SAGE. Results: A total of 6639 students from 22 countries, representing all world regions, responded to the questionnaire properly. Their mean age was 22.1 ± 2.8 (17–40) years, and the majority were females (70.5%), in clinical years (66.8%), and from upper-middle-income economies (45.7%). In general, 22.5% of dental students worldwide were hesitant, and 13.9% rejected COVID-19 vaccines. The students in low- and lower-middle-income (LLMI) economies had significantly higher levels of vaccine hesitancy compared to their peers in upper-middle- and high-income (UMHI) economies (30.4% vs. 19.8%; p < 0.01). Conclusions: The global acceptance level of dental students for COVID-19 vaccines was suboptimal, and their worrisome level of vaccine hesitancy was influenced by the socioeconomic context where the dental students live and study. The media and social media, public figures, insufficient knowledge about vaccines, and mistrust of governments and the pharmaceutical industry were barriers to vaccination. The findings of this study call for further implementation of epidemiology (infectious diseases) education within undergraduate dental curricula.
Converting Climate Change Gridded Daily Rainfall to Station Daily Rainfall—A Case Study at Zengwen Reservoir
Authors: Teng Tse-Yu , Liu Tzu-Ming , Tung Yu-Shiang , Cheng Ke-Sheng
Published: May 2021

With improvements in data quality and technology, the statistical downscaling data of General Circulation Models (GCMs) for climate change impact assessment have been refined from monthly data to daily data, which has greatly promoted the data application level. However, there are differences between GCM downscaling daily data and rainfall station data. If GCM data are directly used for hydrology and water resources assessment, the differences in total amount and rainfall intensity will be revealed and may affect the estimates of the total amount of water resources and water supply capacity. This research proposes a two-stage bias correction method for GCM data and establishes a mechanism for converting grid data to station data. Five GCMs were selected from 33 GCMs, which were ranked by rainfall simulation performance from a baseline period in Taiwan. The watershed of the Zengwen Reservoir in southern Taiwan was selected as the study area for comparison of the three different bias correction methods. The results reveal that the method with the wet-day threshold optimized by objective function with observation rainfall wet days had the best result. Error was greatly reduced in the hydrology model simulation with two-stage bias correction. The results show that the two-stage bias correction method proposed in this study can be used as an advanced method of data pre-processing in climate change impact assessment, which could improve the quality and broaden the extent of GCM daily data. Additionally, GCM ranking can be used by researchers in climate change assessment to understand the suitability of each GCM in Taiwan.
Comparison of Sr Transport in Compacted Homoionous Na and Ca Bentonite Using a Planar Source Method Evaluated at Ideal and Non-Ideal Boundary Condition
Authors: Baborová Lucie , Viglašová Eva , Vopálka Dušan
Published: May 2021

With the aim to determine the influence of dominant interlayer cation on the sorption and diffusion properties of bentonite, diffusion experiments with Sr on the compacted homoionous Ca- and Na-forms of Czech natural Mg/Ca bentonite using the planar source method were performed. The bentonite was compacted to 1400 kg·m−3, and diffusion experiments lasted 1, 3 or 5 days. Two methods of apparent diffusion coefficient Da determination based on the analytical solution of diffusion equation for ideal boundary conditions in a linear form were compared and applied. The determined Da value for Ca-bentonite was 1.36 times higher than that for Na-bentonite sample. Values of Kd were determined in independent batch sorption experiments and were extrapolated for the conditions of compacted bentonite. In spite of this treatment, the use of Kd values determined by batch sorption experiments on a loose material for the determination of effective diffusion coefficient De values from planar source diffusion experiments proved to be inconsistent with the standard Fickian description of diffusion taking into account only the pore diffusion in compacted bentonite. Discrepancies between Kd and De values were measured in independent experiments, and those that resulted from the evaluation of planar source diffusion experiments could be well explained by the phenomenon of surface diffusion. The obtained values of surface diffusion coefficients Ds were similar for both studied systems, and the predicted value of total effective diffusion coefficient De(tot) describing Sr transport in the Na-bentonite was four times higher than in the Ca-bentonite.
Palladium-Supported Zirconia-Based Catalytic Degradation of Rhodamine-B Dye from Wastewater
Authors: Jabeen Salma , Sufaid Khan Muhammad , Khattak Rozina , Zekker Ivar , Burlakovs Juris , Rubin Sergio S. dC , Ghangrekar Makarand Madhao , Kallistova Anna , Pimenov Nikolai , Zahoor Muhammad , Khan Gul Shahzada
Published: May 2021

The catalytic activity of Pd/ZrO2 was studied in terms of the degradation of rhodamine-B dye in the presence of hydrogen peroxide. Pd/ZrO2 was prepared by impregnation method, calcined at 750 °C and characterized by XRD, SEM and EDX. The catalyst showed good catalytic activity for dye degradation at 333 K, using 0.05 g of the catalyst during 5 h. The reaction kinetics followed the pseudo-first order kinetics. The Freundlich, Langmuir and Temkin isotherms were applied to the data and the best fit was obtained with Freundlich isotherm. Thermodynamic parameters, like ΔH, ΔG and ΔS were also calculated. The negative values of ΔH (−291.406 KJ/mol) and Gibbs free energy (ΔG) showed the exothermic and spontaneous nature of the process. The positive ΔS (0.04832 KJ/mol K) value showed suitable affinity of catalyst for dye degradation. The catalyst was very stable, active and was easily separated from the reaction mixture by filtration. It can be concluded from the results that the prepared catalyst could be effectively used in dyes degradation/removal from water subjected to further validation and use for various dyes.
Monitoring, Modeling and Management of Water Quality
Authors: Zessner Matthias
Published: May 2021

In this special issue, we are able to present a selection of high-level contributions showing the manifold aspects of the monitoring, modeling, and management of water quality. Monitoring aspects range from cyanobacteria in water using spectrophotometry via wide-area water quality monitoring and exploiting unmanned surface vehicles, to using sentinel-2 satellites for the near-real-time evaluation of catastrophic floods. Modeling ranges from small scale approaches by deriving a Bayesian network for assessing the retention efficacy of riparian buffer zones, to national scales with a modification of the MONERIS (Modeling Nutrient Emissions in River Systems) nutrient emission model for a lowland country. Management is specifically addressed by lessons learned from the long-term management of a large (re)constructed wetland and the support of river basin management planning in the Danube River Basin.
Treated Wastewater Irrigation—A Review
Authors: Hashem Mahmoud S. , Qi Xuebin
Published: May 2021

As the most important resource for life, water has been a central issue on the international agenda for several decades. Yet, the world’s supply of clean freshwater is steadily decreasing due to extensive agricultural demand for irrigated lands. Therefore, water resources should be used with greater efficiency, and the use of non-traditional water resources, such as Treated Wastewater (TW), should be increased. Reusing TW could be an alternative option to increase water resources. Thus, many countries have decided to turn wastewater into an irrigation resource to help meet urban demand and address water shortages. However, because of the nature of that water, there are potential problems associated with its use in irrigation. Some of the major concerns are health hazards, salinity build-up, and toxicity hazards. The objectives of this comprehensive literature review are to illuminate the importance of using TW in irrigation as an alternative freshwater source and to assess the effects of its use on soil fertility and other soil properties, plants, and public health. The literature review reveals that TW reuse has become part of the extension program for boosting water resource utilization. However, the uncontrolled application of such waters has many unfavorable effects on both soils and plants, especially in the long-term. To reduce these unfavorable effects when using TW in irrigation, proper guidelines for wastewater reuse and management should be followed to limit negative effects significantly.
Integrated Evaluation of the Water Deficit Irrigation Scheme of Indigowoad Root under Mulched Drip Irrigation in Arid Regions of Northwest China Based on the Improved TOPSIS Method
Authors: Wang Zeyi , Zhang Hengjia , Wang Yucai , Zhou Chenli
Published: May 2021

Limited water resources and low water productivity limit the sustainable development of agriculture in northwest China. In this study, drip irrigation under plastic film was used to achieve an optimal water deficit irrigation (WDI) scheme for the cultivation of indigowoad root (Isatis tinctoria L.). Field water control experiments were conducted in 2016 and 2017. Evaluation of WDI schemes was carried out by considering five indices: water consumption, yield, water use efficiency (WUE), indigo, and (R,S)-goitrin. To enhance the reliability of results, the analytic hierarchy process (AHP) and entropy weight method (EWM) were adopted to calculate the combined weight of the evaluation index. Finally, an improved technique for order of preference by similarity to ideal solution (TOPSIS) that integrated AHP–EWM weights was used to construct a unified, comprehensive evaluation model of indigowoad root under mulched drip irrigation that would produce high yield while saving water. The evaluation results indicated that mild WD (specifically, the V1G1 treatment) was continuously exerted during the vegetative and fleshy root growth periods, which enhanced the WUE and improved the quality of indigowoad root to a certain extent without significantly reducing the yield. These results provide a scientific basis for irrigation of indigowoad in northwest China and other areas with a similar environment.
Is the Volume-of-Fluid Method Coupled with a Sub-Grid Bubble Equation Efficient for Simulating Local and Continuum Aeration?
Authors: Mendes Lourenço Sassetti , Lara Javier L. , Viseu Maria Teresa
Published: May 2021

Air entrainment is common in free surface flows in large hydraulic structures (e.g., spillways, chutes, energy dissipation structures) and must be considered to assure an effective and safe operation. Due to the large size of the prototype structures, it is infeasible to model individual air bubbles. Therefore, using the OpenFOAM toolbox, an efficient simulation model for aerated flows is developed for engineering purposes. The Reynolds-averaged Navier–Stokes equations and the volume-of-fluid method are coupled with a sub-grid bubble population model that simulates entrainment and transport. A comprehensive assessment of the effectiveness, computational cost, and reliability is performed. Local and continuum bubble entrainment are evaluated in two distinct flows: an impinging jet and along a spillway chute. Aeration is induced, respectively, by a shear flow and by the thickening of the turbulent boundary layer. Moreover, a detailed sensitivity analysis of the model’s parameters is conducted. Calibration and validation are performed against experimental and prototype data. Among the analyzed entrainment formulations, the one depending exclusively on the turbulent kinetic energy is the only applicable to different flow types. Good accuracy is found, meeting engineering standards, and the additional computation cost is marginal. Results depend primarily on the volume-of-fluid method ability to reproduce the interface. Calibration is straightforward in self-aeration but more difficult for local aeration.
Optimal Return Policies and Micro-Plastics Prevention Based on Environmental Quality Improvement Efforts and Consumer Environmental Awareness
Authors: Wang Dong , Wang Kehong , Chen Yujing
Published: May 2021

Consumers initiating returns online may produce secondary packaging, while most of the packages are produced by plastics. The more products are returned, the more plastics are used. Existing research indicates that the plastic packages can contribute to the micro-plastics pollution of the environment. As consumer environmental awareness (CEA) improves, more and more consumers are willing to pay extra fees to change the materials of packages from plastics to others in order to protect the environment, prompting enterprises to adjust to their return policies. In this context, this paper takes environmental quality improvement effort and the environmental coefficient as decision variables, and compares the manufacturer’s optimal decisions under with and without return policy. Our results show as follows: (1) There is a positive correlation between CEA and environmental quality improvement effort and the environmental coefficient; that is, environmental quality improvement effort and the environmental coefficient increase with an increase in CEA; (2) When CEA is high (k≤τ≤d), there is a threshold for manufacturers to invest in environmental effort. However, when CEA is low (0≤τ≤k), regardless of the return policy the manufacturer implements, its profit increases with the promotion of CEA, and when the manufacturer allows consumer returns, the relationship is more obvious; (3) The manufacturer should adopt an appropriate return policy according to the changes in CEA. When CEA is low (0≤τ≤k), the manufacturer should adopt a without return policy; when CEA is high (k≤τ≤d), the manufacturer should adopt a full refund (r=p) return policy, which is the optimal profit, and increase investment in environmental protection. From the above conclusions, we suggest that the government should increase the publicity of environmental protection, consumers should establish the awareness of green consumption, and enterprises should increase investment in environmental quality improvement to achieve sustainable development.
Effect of Using Multi-Year Land Use Land Cover and Monthly LAI Inputs on the Calibration of a Distributed Hydrologic Model
Authors: Busari Ibrahim Olayode , Demirel Mehmet Cüneyd , Newton Alice
Published: May 2021

Effective management of water resources entails the understanding of spatiotemporal changes in hydrologic fluxes with variation in land use, especially with a growing trend of urbanization, agricultural lands and non-stationarity of climate. This study explores the use of satellite-based Land Use Land Cover (LULC) data while simultaneously correcting potential evapotranspiration (PET) input with Leaf Area Index (LAI) to increase the performance of a physically distributed hydrologic model. The mesoscale hydrologic model (mHM) was selected for this purpose due to its unique features. Since LAI input informs the model about vegetation dynamics, we incorporated the LAI based PET correction option together with multi-year LULC data. The Globcover land cover data was selected for the single land cover cases, and hybrid of CORINE (coordination of information on the environment) and MODIS (Moderate Resolution Imaging Spectroradiometer) land cover datasets were chosen for the cases with multiple land cover datasets. These two datasets complement each other since MODIS has no separate forest class but more frequent (yearly) observations than CORINE. Calibration period spans from 1990 to 2006 and corresponding NSE (Nash-Sutcliffe Efficiency) values varies between 0.23 and 0.42, while the validation period spans from 2007 to 2010 and corresponding NSE values are between 0.13 and 0.39. The results revealed that the best performance is obtained when multiple land cover datasets are provided to the model and LAI data is used to correct PET, instead of default aspect-based PET correction in mHM. This study suggests that to minimize errors due to parameter uncertainties in physically distributed hydrologic models, adequate information can be supplied to the model with care taken to avoid over-parameterizing the model.
Removal of AOX in Activated Sludge of Industrial Chemical Dyestuff with Bimetallic Pd/Fe Particles
Authors: Xu Cancan , Liu Rui , Zheng Wei , Lin Lichu , Chen Lvjun
Published: May 2021

Pd/Fe bimetallic particles were synthesized by chemical deposition and used to remove absorbable organic halogens (AOX) in the activated sludge of a chemical dyestuff wastewater treatment plant. Bath experiments demonstrated that the Pd/Fe bimetallic particles could effectively remove AOX. It indicated several factors, such as Pd loading, the amount of Pd/Fe used, initial activated sludge pH, and reaction time, which could affect the removal effect. The results showed that increasing the Pd content in Pd/Fe particles, from 0.01 to 0.05 wt %, significantly increased the removal efficiency of AOX in activated sludge. The Pd/Fe particles had a much higher removal efficiency of AOX in the activated sludge than bare Fe particles. A slightly acidic condition with a Pd content of 0.05% and 10 g/L of Pd/Fe was beneficial to the process of removing AOX in activated sludge. In detail, the removal efficiency of AOX in the activated sludge could reach 50.7% after 15 days of reaction with 10 g/L of Pd/Fe (Pd loading 0.05 wt %) and at an initial pH of 6.0 during the experiments. It also showed that the control samples without Fe0 and Fe/Pd additions only removed 7.9% of AOX under the same conditions. Meanwhile, the concentrations of AOX in the supernatant of activated sludge were lower than the initial AOX concentration in the supernatant during the activated sludge remediation with Pd/Fe bimetallic particles. The results indicated that the AOX removal from the activated sludge matrix might be mainly due to the Pd/Fe bimetallic particles, and not just by phase transfer.
Application of SWAT in Hydrological Simulation of Complex Mountainous River Basin (Part I: Model Development)
Authors: Marahatta Suresh , Devkota Laxmi Prasad , Aryal Deepak
Published: May 2021

The soil and water assessment tool (SWAT) hydrological model has been used extensively by the scientific community to simulate varying hydro-climatic conditions and geo-physical environment. This study used SWAT to characterize the rainfall-runoff behaviour of a complex mountainous basin, the Budhigandaki River Basin (BRB), in central Nepal. The specific objectives of this research were to: (i) assess the applicability of SWAT model in data scarce and complex mountainous river basin using well-established performance indicators; and (ii) generate spatially distributed flows and evaluate the water balance at the sub-basin level. The BRB was discretised into 16 sub-basins and 344 hydrological response units (HRUs) and calibration and validation was carried out at Arughat using daily flow data of 20 years and 10 years, respectively. Moreover, this study carried out additional validation at three supplementary points at which the study team collected primary river flow data. Four statistical indicators: Nash–Sutcliffe efficiency (NSE), percent bias (PBIAS), ratio of the root mean square error to the standard deviation of measured data (RSR) and Kling Gupta efficiency (KGE) have been used for the model evaluation. Calibration and validation results rank the model performance as “very good”. This study estimated the mean annual flow at BRB outlet to be 240 m3/s and annual precipitation 1528 mm with distinct seasonal variability. Snowmelt contributes 20% of the total flow at the basin outlet during the pre-monsoon and 8% in the post monsoon period. The 90%, 40% and 10% exceedance flows were calculated to be 39, 126 and 453 m3/s respectively. This study provides additional evidence to the SWAT diaspora of its applicability to simulate the rainfall-runoff characteristics of such a complex mountainous catchment. The findings will be useful for hydrologists and planners in general to utilize the available water rationally in the times to come and particularly, to harness the hydroelectric potential of the basin.
Comparison of Forecasting Models for Real-Time Monitoring of Water Quality Parameters Based on Hybrid Deep Learning Neural Networks
Authors: Sha Jian , Li Xue , Zhang Man , Wang Zhong-Liang
Published: May 2021

Accurate real-time water quality prediction is of great significance for local environmental managers to deal with upcoming events and emergencies to develop best management practices. In this study, the performances in real-time water quality forecasting based on different deep learning (DL) models with different input data pre-processing methods were compared. There were three popular DL models concerned, including the convolutional neural network (CNN), long short-term memory neural network (LSTM), and hybrid CNN–LSTM. Two types of input data were applied, including the original one-dimensional time series and the two-dimensional grey image based on the complete ensemble empirical mode decomposition algorithm with adaptive noise (CEEMDAN) decomposition. Each type of input data was used in each DL model to forecast the real-time monitoring water quality parameters of dissolved oxygen (DO) and total nitrogen (TN). The results showed that (1) the performances of CNN–LSTM were superior to the standalone model CNN and LSTM; (2) the models used CEEMDAN-based input data performed much better than the models used the original input data, while the improvements for non-periodic parameter TN were much greater than that for periodic parameter DO; and (3) the model accuracies gradually decreased with the increase of prediction steps, while the original input data decayed faster than the CEEMDAN-based input data and the non-periodic parameter TN decayed faster than the periodic parameter DO. Overall, the input data preprocessed by the CEEMDAN method could effectively improve the forecasting performances of deep learning models, and this improvement was especially significant for non-periodic parameters of TN.
Vulnerability of Hydraulic Constructions in Flood-Prone Agricultural Areas
Authors: Biscarini Chiara , Di Francesco Silvia , Casadei Stefano , Venturi Sara , Manciola Piergiorgio
Published: May 2021

The conditions of high hydraulic risk are mainly due to the interference between the river network and bridges, their relative access ramps and road embankments located in the floodplain. Actually, bridges are not always structurally adequate to withstand severe flood waves. In flood restoration works, there is an objective difficulty in implementing the structural safety of bridges because of historical, artistic and economic issues. Thus, the risk mitigation strategy often accounts for the assessment of the vulnerability degree of each bridge/road embankment according to an evaluation scale. Here we present a methodology regarding the classification of the vulnerability degree and its application to 84 works located in the alluvial area of the Tiber River, in the area of the Province of Perugia. For the purposes of a synthetic classification of works vulnerability, the individual assessed parameters are compared by means of subsequent contingency tables in order to compute the resulting vulnerability degree.
Antropofagia como descentramiento de Europa
Authors: Castañeda Sánchez Érika
Published: May 2021

El presente escrito hace una aproximación al trabajo literario de Oswald de Andrade desde la perspectiva benjaminiana de la historia que permite pensar un nuevo lugar para América Latina. Para alcanzar tal objetivo nos centraremos en el concepto de antropofagia a partir de dos importantes obras del autor: el “Manifiesto da poesía Pau-Brasil” (1924) y el “Manifiesto Antropófago” (1928), en las cuales de Andrade expone lo que entiende por antropofagia y cómo esta sería la característica del salvaje americano. Las afirmaciones realizadas por el escritor brasilero serán analizadas teniendo en cuenta dos aspectos del materialismo histórico propuesto por Walter Benjamin, el rechazo a la idea de progreso y la trituración del valor tradicional de la obra de arte.
Elástico de sombra, Juan Cárdenas. Madrid: Sexto Piso, 2019
Authors: Acevedo Rendón Julian
Published: May 2021

Elástico de sombra (Sexto Piso, 2019) expone las problemáticas que reflejan las prácticas culturales y económicas de las poblaciones minoritarias de este país —me refiero a las negritudes y los indígenas— como la producción del cacao, el tabaco, el algodón y el aguardiente, que en realidad han sido colonizadas por el supremacismo blanco, reafirmando de esta forma el lumpen capitalista.
Esperrància: O lugar da espera e da errância
Authors: Fuao Fernado Freitas
Published: May 2021

Esse ensaio apresenta algumas possibilidades do pensamento sobre hospitalidade-acolhimento enunciado pelo filósofo Jacques Derrida. Considera a teoria dos Encontros na collage como um modo de avançar nas obscuras relações entre hospede e hospedeiro. Para tanto essas duas figuras são comparadas analogamente com as figuras da espera e da errância, conforme as apresentadas em A collage como trajetória amorosa. Procura-se mostrar que, a questão da hospitalidade tem a propriedade de unir as diferenças, porém conservando-as enquanto diferenças. Dessa maneira, a espera e a errância seriam consideradas entidades indissociáveis uma da outra.
Human rights violations and genocide: Lessons of Rwanda
Authors: Voloshchuk Oksana , Kolesnyk Victoriia , Hetmantsev Maxim
Published: May 2021

The purpose of the article is a comprehensive analysis of the Rwandan genocide through the prism of human rights violations. To achieve this goal, such methods as historical-legal, comparative, formal-dogmatic, logical-semantic and analysis were used. The article argues that the acts of genocide clearly provide for the guilty intent and use of a state mechanism that has all the required human and material resources to implement such a plan. This feature is one of the key in terms of revealing the essence of genocide, so it can differentiate these actions from the general murder under criminal law and shows, depending on the object of distribution - life, health of a certain group of people - and motives - national, ethnic , racial or religious intolerance, hostility - its increased social danger. It is concluded that the inclusion of such a feature as one of the basic to the universal definition is urgent. This will allow to more fully implement the principle of inevitability of punishment for all perpetrators, to recognize the state as a subject of responsibility and thus will contribute to a more effective implementation of the preventive function in the international arena. The combined efforts of all nations and peoples are needed to fight, combat and prevent the crime of genocide. The positive results would be achieved only by joint efforts by using a set of various means of combating genocide.
Civil and criminal liability in the field of transport relations: the impact of the Covid-19 pandemic
Authors: Minchenko Raisa , Lutsyuk Pavlo , Kamensky Dmitriy , Kolodin Artem , Shamota Oleksandr
Published: May 2021

The COVID-19 pandemic has changed the lives not only of many people but also significantly affected the economy of individual countries and the world economy as a whole. The world has seen a reduction in production capacity due to the closure of borders between countries and the introduction of self-isolation. The coronavirus pandemic has disrupted the usual relationship between manufacturers and users and has made a major difference in transport. Such changes have been reflected in the regulation of relations regarding civil and criminal liability for offenses in the field of transport relations in a coronavirus pandemic. With this in mind, it is important to analyze the transformations of civil and criminal liability in the field of transport due to the Covid-19 pandemic. The work aims to analyze the civil and criminal liability in the field of transport relations due to the Covid-19 pandemic. The object of the study is a civil and criminal liability in the field of transport due to the Covid-19 pandemic. The subject of the study is the public relations that arise, change, and end during the prosecution of civil and criminal transport in the wake of the Covid-19 pandemic. The research methodology consists of such methods as the analytical method, historical method, method of analysis of legal documents, articles, and monographs, method of generalization, comparison, synthesis, and modeling. The study will analyze the changes that have taken place in the field of transport, namely the peculiarities of civil and criminal liability for violations in the field of transport during the Covid-19 pandemic, as well as clarify the problematic issues of prosecution in the field of transport and controversial aspects pre-trial settlement of conflicts by the parties. The research also identified the main trends in the transport sphere in the context of the Covid-19 pandemic and explained what changes need to be made to establish a mechanism for civil and criminal liability in the field of transport due to the Covid-19 pandemic.
Cassation filters in administrative judicial procedure: a step in a chasm or a novel that ukrainian society expected?
Authors: Drozd Oleksii , Dorokhina Yuliia , Leheza Yuliia , Smokovych Mykhailo , Zadyraka Natalia
Published: May 2021

The purpose of the article is to characterize the grounds for the use of "cassation administrative filters" as part of the mechanism for exercising the right of an individual to cassation appeal against a court decision in a public law dispute. The subject of research is the peculiarities of cassation review of decisions in administrative proceedings. Methodology: The methodological basis for the article are general and special methods of legal science, in particular: the method of dialectical analysis, the method of prognostic modeling, formal and logical, normative and dogmatic, sociological methods. The results of the study: The current regulations on the right of an individual to cassation appeal against court decisions in administrative proceedings by characterizing the existing procedural filters are analyzed. Practical implication: Based on the study of the case law, the types of administrative cassation filters applied by the courts when reviewing the decisions are identified. Value / originality: It is proved that achieving the effectiveness of the application of cassation administrative filters requires a high level of professionalism, which ensures the proper implementation of the individual’s right to file a cassation appeal, and developing the unified approach to the use of assessment categories.