bluuebunny/crossref_metadata_2025 huggingface dataset:
IgG4 disease with multiorgan involvement: a case report
Authors: Vidanapathirana M. N. , Wijayaratne D.
Published: February 2024

Background

IgG4-related disease (IgG4RD) is a rare fibroinflammatory disease with multiorgan involvement. It presents insidiously over several years and can be a diagnostic enigma. Delays in diagnosis occur due to failure to consider IgG4 as a differential diagnosis, atypical presentations, and an insidious clinical course.

Case presentation

We report the case of a 70-year-old Sri Lankan man with pulmonary, renal, and neurological involvement of IgG4-related disease. Clinical manifestations evolved over a 4-year period and included exertional shortness of breath and dysesthesia of extremities. The diagnosis was established with clinical, radiological, and pathological criteria laid down by The American College of Rheumatology/European League Against Rheumatism in 2019.

Following diagnosis, the patient was started on oral steroids, with rapid improvement of his respiratory and neurological symptoms. He is currently under follow-up and will be monitored with clinical and radiological parameters, complement levels, and lung function tests.

Conclusion

This case outlines the presentation of a patient with IgG4-related disease with concurrent involvement of three uncommon sites. It highlights methods of diagnostic deduction by considering the clinical course of illness, imaging, and histopathology. It also describes evolving associations of IgG4-related disease with tuberculosis and lymphomas, which bear important diagnostic and therapeutic considerations.
Confronting the complexities of antimicrobial management for Staphylococcus aureus causing bovine mastitis: an innovative paradigm
Authors: Saeed Shamsaldeen Ibrahim , Kamaruzzaman Nor Fadhilah , Gahamanyi Noel , Nguyen Thi Thu Hoai , Hossain Delower , Kahwa Ivan
Published: February 2024

Globally, Mastitis is a disease commonly affecting dairy cattle which leads to the use of antimicrobials. The majority of mastitis etiological agents are bacterial pathogens and Staphylococcus aureus is the predominant causative agent. Antimicrobial treatment is administered mainly via intramammary and intramuscular routes. Due to increasing antimicrobial resistance (AMR) often associated with antimicrobial misuse, the treatment of mastitis is becoming challenging with less alternative treatment options. Besides, biofilms formation and ability of mastitis-causing bacteria to enter and adhere within the cells of the mammary epithelium complicate the treatment of bovine mastitis. In this review article, we address the challenges in treating mastitis through conventional antibiotic treatment because of the rising AMR, biofilms formation, and the intracellular survival of bacteria. This review article describes different alternative treatments including phytochemical compounds, antimicrobial peptides (AMPs), phage therapy, and Graphene Nanomaterial-Based Therapy that can potentially be further developed to complement existing antimicrobial therapy and overcome the growing threat of AMR in etiologies of mastitis.
COVID-19 vaccination hesitancy among Malawians: a scoping review
Authors: Nkambule Ellen , Mbakaya Balwani Chingatichifwe
Published: February 2024

Background

The best chance of eradicating the COVID-19 pandemic lies in a successful vaccination campaign against the virus. There is still hesitancy among some of the Malawians over the use of COVID-19 vaccines that are readily available. This review’s objective was to currently analyze COVID-19 vaccination hesitancy among Malawians.

Methods

This scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for Scoping Reviews. An electronic database search was performed using CINAHL, OVID Medline, PubMed, and Google Scholar for studies published between January 1, 2020, and July 10, 2023, on the topic of reluctance toward COVID-19 vaccine in Malawi. A review of the journal titles and abstracts was performed to establish a match within the selection criteria. Based on the parameters of interest, this paper included publications that explicitly mentioned COVID-19 vaccine hesitancy in Malawi.

Results

A total of seven articles were identified as meeting the inclusion criteria. Some of the eligible Malawian population’s poor response to COVID-19 vaccination was due to hesitancy. Misinformation is primarily to blame for COVID-19 vaccine reluctance. COVID-19 vaccines are viewed as dangerous or intended to cause harm such as the myth that the COVID-19 vaccine would cause infertility, severe disability, and even death. The review revealed that some people choose not to receive vaccines due to religious convictions and beliefs. Some individuals also think that getting the COVID-19 vaccine could result in receiving a triple-six (666) mark from the devil. There were also reports that the COVID-19 vaccination is being considered experimental and ineffective.

Conclusions

The Malawi government should focus on fear and misinformation regarding COVID-19 vaccination campaigns, using interventions, motivational interviews, and individual sensitization. Traditional, religious, and youth-led organizations should provide practical information on COVID-19 vaccine safety and efficacy.
Dynamic changes of rumen microbiota and serum metabolome revealed increases in meat quality and growth performances of sheep fed bio-fermented rice straw
Authors: Kyawt Yin Yin , Aung Min , Xu Yao , Sun Zhanying , Zhou Yaqi , Zhu Weiyun , Padmakumar Varijakshapanicker , Tan Zhankun , Cheng Yanfen
Published: February 2024

Background

Providing high-quality roughage is crucial for improvement of ruminant production because it is an essential component of their feed. Our previous study showed that feeding bio-fermented rice straw (BF) improved the feed intake and weight gain of sheep. However, it remains unclear why feeding BF to sheep increased their feed intake and weight gain. Therefore, the purposes of this research were to investigate how the rumen microbiota and serum metabolome are dynamically changing after feeding BF, as well as how their changes influence the feed intake, digestibility, nutrient transport, meat quality and growth performances of sheep. Twelve growing Hu sheep were allocated into 3 groups: alfalfa hay fed group (AH: positive control), rice straw fed group (RS: negative control) and BF fed group (BF: treatment). Samples of rumen content, blood, rumen epithelium, muscle, feed offered and refusals were collected for the subsequent analysis.

Results

Feeding BF changed the microbial community and rumen fermentation, particularly increasing (P < 0.05) relative abundance of Prevotella and propionate production, and decreasing (P < 0.05) enteric methane yield. The histomorphology (height, width, area and thickness) of rumen papillae and gene expression for carbohydrate transport (MCT1), tight junction (claudin-1, claudin-4), and cell proliferation (CDK4, Cyclin A2, Cyclin E1) were improved (P < 0.05) in sheep fed BF. Additionally, serum metabolome was also dynamically changed, which led to up-regulating (P < 0.05) the primary bile acid biosynthesis and biosynthesis of unsaturated fatty acid in sheep fed BF. As a result, the higher (P < 0.05) feed intake, digestibility, growth rate, feed efficiency, meat quality and mono-unsaturated fatty acid concentration in muscle, and the lower (P < 0.05) feed cost per kg of live weight were achieved by feeding BF.

Conclusions

Feeding BF improved the growth performances and meat quality of sheep and reduced their feed cost. Therefore, bio-fermentation of rice straw could be an innovative way for improving ruminant production with minimizing production costs.

Graphical Abstract
Is there any way to increase consumers’ purchase intention regarding surplus food blind-boxes? An exploratory study
Authors: Sun Jie , Wang Yanan , Yang Chun , Chen Jiangjie , Wei Wei , Miao Wei , Sun Hanchu , Gu Chao
Published: February 2024

As an emerging business model, merchants are selling surplus food in blind boxes, which provides new opportunities for reducing waste and promoting sustainable development. Surplus food blind boxes, however, have not been extensively researched in terms of design and marketing strategies. Therefore, we are examining how to increase consumers’ purchase intention regarding surplus food blind boxes as well as the relationship between purchase intention, continuous intention, and recommendation intention. In this paper, two studies are conducted. As part of study 1, We used factor analysis to explore the reasons that influence consumers to purchase. In study 2, we utilized structural equation modeling to examine the impact of purchase intention on continuous intention and recommendation intention. Results indicate that food quality, perceived sustainability, and conspicuous consumption are the most important positive factors. The most important negative factors are perceived food risk, resistance to sales techniques, taste anxiety, and inadequate marketing strategies. Based on our findings, we constructed a path relationship between purchase intention, continuous intention, and recommendation intention. The purchase intention of the surplus food blind box users directly influences the recommendation intention and the continuous intention, while the recommendation intention indirectly influences the continuous intention. This study did not demonstrate that gender had a moderating effect. Meanwhile, it provides a reference for the actual marketing management of surplus food blind box merchants.
Modeling the link between environmental, social, and governance disclosures and scores: the case of publicly traded companies in the Borsa Istanbul Sustainability Index
Authors: Kartal Mustafa Tevfik , Kılıç Depren Serpil , Pata Ugur Korkut , Taşkın Dilvin , Şavlı Tuba
Published: February 2024

This study constructs a proposed model to investigate the link between environmental, social, and governance (ESG) disclosures and ESG scores for publicly traded companies in the Borsa Istanbul Sustainability (XUSRD) index. In this context, this study considers 66 companies, examining recently structured ESG disclosures for 2022 that were published for the first time as novel data and applying a multilayer perceptron (MLP) artificial neural network algorithm. The relevant results are fourfold. (1) The MLP algorithm has explanatory power (i.e., R2) of 79% in estimating companies’ ESG scores. (2) Common, environment, social, and governance pillars have respective weights of 21.04%, 44.87%, 30.34%, and 3.74% in total ESG scores. (3) The absolute and relative significance of each ESG reporting principle for companies’ ESG scores varies. (4) According to absolute and relative significance, the most effective ESG principle is the common principle, followed by social and environmental principles, whereas governance principles have less significance. Overall, the results demonstrate that applying a linear approach to complete deficient ESG disclosures is inefficient for increasing companies’ ESG scores; instead, companies should focus on the ESG principles that have the highest relative significance. The findings of this study contribute to the literature by defining the most significant ESG principles for stimulating the ESG scores of companies in the XUSRD index.
Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease
Authors: Supakul Sopak , Murakami Rei , Oyama Chisato , Shindo Tomoko , Hatakeyama Yuki , Itsuno Maika , Bannai Hiroko , Shibata Shinsuke , Maeda Sumihiro , Okano Hideyuki
Published: February 2024

Background

The development of induced pluripotent stem cells (iPSCs) technology has enabled human cellular disease modeling for inaccessible cell types, such as neural cells in the brain. However, many of the iPSC-derived disease models established to date typically involve only a single cell type. These monoculture models are inadequate for accurately simulating the brain environment, where multiple cell types interact. The limited cell type diversity in monoculture models hinders the accurate recapitulation of disease phenotypes resulting from interactions between different cell types. Therefore, our goal was to create cell models that include multiple interacting cell types to better recapitulate disease phenotypes.

Methods

To establish a co-culture model of neurons and astrocytes, we individually induced neurons and astrocytes from the same iPSCs using our novel differentiation methods, and then co-cultured them. We evaluated the effects of co-culture on neurons and astrocytes using immunocytochemistry, immuno-electron microscopy, and Ca2+ imaging. We also developed a co-culture model using iPSCs from a patient with familial Alzheimer's disease (AD) patient (APPV717L mutation) to investigate whether this model would manifest disease phenotypes not seen in the monoculture models.

Results

The co-culture of the neurons and astrocytes increased the branching of astrocyte processes, the number of GFAP-positive cells, neuronal activities, the number of synapses, and the density of presynaptic vesicles. In addition, immuno-electron microscopy confirmed the formation of a tripartite synaptic structure in the co-culture model, and inhibition of glutamate transporters increased neuronal activity. Compared to the co-culture model of the control iPSCs, the co-culture model of familial AD developed astrogliosis-like phenotype, which was not observed in the monoculture model of astrocytes.

Conclusions

Co-culture of iPSC-derived neurons and astrocytes enhanced the morphological changes mimicking the in vivo condition of both cell types. The formation of the functional tripartite synaptic structures in the co-culture model suggested the mutual interaction between the cells. Furthermore, the co-culture model with the APPV717L mutation expressed in neurons exhibited an astrocytic phenotype reminiscent of AD brain pathology. These results suggest that our co-culture model is a valuable tool for disease modeling of neurodegenerative diseases.
Real-world use and clinical impact of an electronic patient-reported outcome tool in patients with solid tumors treated with immuno-oncology therapy
Authors: Dickson Natalie R , Beauchamp Karen D , Perry Toni S , Roush Ashley , Goldschmidt Deborah , Edwards Marie Louise , Blakely L Johnetta
Published: February 2024

Background

Utilization of electronic patient-reported outcome (ePRO) tools to monitor symptoms in patients undergoing cancer treatment has shown clinical benefits. Tennessee Oncology (TO) implemented an ePRO platform in 2019, allowing patients to report their health status online. We conducted a real-world, multicenter, observational, non-interventional cohort study to evaluate utilization of this platform in adults with solid tumors who initiated immuno-oncology (IO) therapy as monotherapy or in combination at TO clinics.

Methods

Patients initiating IO therapy prior to platform implementation were included in a historical control (HC) cohort; those initiating treatment after implementation were included in the ePRO cohort, which was further divided into ePRO users (platform enrollment ≤ 45 days from IO initiation) and non-users. Data were extracted from electronic medical records; patients were followed for up to 6 months (no minimum follow up). Outcomes included patient characteristics, treatment patterns, duration of therapy (DoT), and overall survival (OS).

Results

Data were collected for 538 patients in the HC and 1014 in the ePRO cohort; 319 in the ePRO cohort were ePRO users (uptake rate 31%). Baseline age was higher, more patients had stage IV disease at diagnosis, and more received monotherapy (82 vs 52%, respectively) in the HC vs the ePRO cohort. Median follow-up was 181.0 days (range 0.0–182.6) in the HC and 175.0 (0.0–184.0) in the ePRO cohort. Median DoT of index IO regimen was 5.1 months (95% confidence interval [CI], 4.4–NE) in the HC cohort vs not estimable (NE) in the ePRO cohort. Multivariable regression adjusting for baseline differences confirmed lower risk of treatment discontinuation in the ePRO vs HC cohort: hazard ratio (HR) 0.83 (95% CI, 0.71–0.97); p < 0.05. The estimated 6-month OS rate was 65.5% in the HC vs 72.4% in the ePRO cohort (p < 0 .01). Within the ePRO cohort, DoT of index IO regimen and OS did not differ between users and non-users. In ePRO users, patient platform use was durable over 6 months.

Conclusion

Improvements in DoT and OS were seen after ePRO platform implementation. Conclusions are limited by challenges in separating the impact of platform implementation from other changes affecting outcomes.
Viabahn stent graft for arterial injury management: safety, technical success, and long-term outcome
Authors: Brendel Jan M. , Mangold Tobias , Lescan Mario , Schmehl Jörg , Ghibes Patrick , Grimm Antonia , Greulich Simon , Krumm Patrick , Artzner Christoph , Grözinger Gerd , Estler Arne
Published: February 2024

Background

The Viabahn stent graft has emerged as an integral tool for managing vascular diseases, but there is limited long-term data on its performance in emergency endovascular treatment. This study aimed to assess safety, technical success, and long-term efficacy of the Viabahn stent graft in emergency treatment of arterial injury.

Methods

We conducted a retrospective single tertiary centre analysis of patients who underwent Viabahn emergency arterial injury treatment between 2015 and 2020. Indication, intraoperative complications, technical and clinical success, and major adverse events at 30 days were evaluated. Secondary efficacy endpoints were the primary and secondary patency rates assessed by Kaplan–Meier analysis.

Results

Forty patients (71 ± 13 years, 19 women) were analyzed. Indications for Viabahn emergency treatment were extravasation (65.0%), arterio-venous fistula (22.5%), pseudoaneurysm (10.0%), and arterio-ureteral fistula (2.5%). No intraoperative adverse events occurred, technical and clinical success rates were 100%. One acute stent graft occlusion occurred in the popliteal artery on day 9, resulting in a 30-day device-related major-adverse-event rate of 2.5%. Median follow-up was 402 days [IQR, 43–1093]. Primary patency rate was 97% (95% CI: 94–100) in year 1, and 92% (95% CI: 86–98) from years 2 to 6. One stent graft occlusion occurred in the external iliac artery at 18 months; successful revascularization resulted in secondary patency rates of 97% (95% CI: 94–100) from years 1 to 6.

Conclusion

Using Viabahn stent graft in emergency arterial injury treatment had 100% technical and clinical success rates, a low 30-day major-adverse-event rate of 2.5%, and excellent long-term patency rates.
Clinical and radiological results of high tibial of osteotomy over the age of 65 are comparable to that of under 55 at minimum 2-year follow-up: a propensity score matched analysis
Authors: Park Jae-Young , Kim Jae-Hwa , Cho Jin-woo , Kim Min soo , Choi Wonchul
Published: February 2024

Purpose

The results of medial open-wedge high tibial osteotomy (MOWHTO) according to age is inconclusive. This study aimed to compare the clinical outcomes and failure of MOWHTO in patients < 55 years and > 65 years.

Methods

Consecutive patients who underwent MOWHTO from July 2009 to August 2020 were retrospectively analyzed. 205 patients were considered for analysis. A 1-to-1 propensity score matched analysis to assess clinical outcomes scores including International Knee Documentation Committee (IKDC) subjective score and Lysholm score, radiologic outcomes, complication, and Total Knee Arthroplasty (TKA) conversion between patients > 65 years and patients < 55 years was performed. Radiologic outcomes included Hip-Knee-Ankle (HKA) angle, Weight Bearing Line ratio (WBLR), posterior tibial slope (PTS), and Insall-Salvati (IS) ratio before and after surgery.

Results

The follow-up period was 50.4 months in patients > 65 years and 55.3 months in patients < 55 years. There was no significant difference in the preoperative and postoperative HKA angle, WBLR, PTS, IS ratio, IKDC score and Lysholm score between the two groups. The arthroscopic evaluation of cartilage did not show any statistically significant differences between the two groups. Regarding Minimal clinically important differences (MCID), in the 26% of the older group exceeded MCID of IKDC score; 45% of the older group exceeded MCID of Lysholm score. In the younger group, 24% exceeded MCID of IKDC score and 35% exceeded MCID of Lysholm score. In older group, there were 7 (11.3%) cases of TKA conversion while no TKA conversion was recorded in the younger group. (P = 0.007) The average time to TKA conversion was 67 months. (42 months to 90 months) Kaplan–Meier analysis revealed that the survival rate was 95.2% at 4 years in the older group.

Conclusion

Similar clinical results were obtained in patients over 65 years of age that were eligible for MOWHTO at minimum 2-year follow-up as in patients under 55 years of age. MOWHTO may be a viable option in older patients if proper indications are met. However, the risk of TKA conversion must be considered preoperatively and discussed with patients.

Study Design: Cohort study; Level of evidence, 3.
Collision frequency measurement from optical reflectivity of laser indirect-driven CH/Al/diamond
Authors: Zhang Zhiyu , Hou Yong , Zhao Yang , Zhang Jiyan , Xu Tao , Jing Longfei , Qing Bo , Xiong Gang , Lv Min , Wang Feng , Du Huabing , Zhan Xiayu , Song Tianming , Huang Chengwu , Zhu Tuo , Zhang Yuxue , Zhao Yan , Zhang Lu , Li Liling , Yang Jiamin
Published: February 2024

A collision frequency measurement from the optical reflectivity of laser indirect-driven CH/Al/diamond on the SG-10kJ laser facility is presented. The optical reflectivity and the Al/diamond interface velocity were measured simultaneously by the velocity interferometer. The aluminum rear surface density was deduced from the interface velocity by analyzing the wave interaction. The deduced sample state was compared with the simulation and quite good agreement was found. The electron collision frequency was deduced by fitting the sample state to the optical reflectivity, and it is found that the experimental collision frequency agrees with a semi-empirical result within the error bar, but is larger than the simulated result based on the average-atom model with the hypernetted chain approximation.
Physical Activity, Sedentary Behavior, and Pancreatic Cancer Risk: A Mendelian Randomization Study
Authors: Gentiluomo Manuel , Dixon-Suen Suzanne C , Farinella Riccardo , Peduzzi Giulia , Canzian Federico , Milne Roger L , Lynch Brigid M , Campa Daniele
Published: February 2024

Pancreatic cancer is currently the seventh leading cause of cancer death worldwide. Understanding whether modifiable factors increase or decrease the risk of this disease is central to facilitating primary prevention. Several epidemiological studies have described the benefits of physical activity, and the risks associated with sedentary behavior, in relation to cancer. This study aimed to assess evidence of causal effects of physical activity and sedentary behavior on pancreatic cancer risk. We conducted a two-sample Mendelian randomization study using publicly available data for genetic variants associated with physical activity and sedentary behavior traits and genetic data from the Pancreatic Cancer Cohort Consortium (PanScan), the Pancreatic Cancer Case-Control Consortium (PanC4), and the FinnGen study for a total of 10 018 pancreatic cancer cases and 266 638 controls. We also investigated the role of body mass index (BMI) as a possible mediator between physical activity and sedentary traits and risk of developing pancreatic cancer. We found evidence of a causal association between genetically determined hours spent watching television (hours per day) and increased risk of pancreatic cancer for each hour increment (PanScan-PanC4 odds ratio = 1.52, 95% confidence interval 1.17-1.98, P = .002). Additionally, mediation analysis showed that genetically determined television-watching time was strongly associated with BMI, and the estimated proportion of the effect of television-watching time on pancreatic cancer risk mediated by BMI was 54%. This study reports the first Mendelian randomization-based evidence of a causal association between a measure of sedentary behavior (television-watching time) and risk of pancreatic cancer and that this is strongly mediated by BMI.

Summary: Pancreatic cancer is a deadly disease that is predicted to become the second leading cause of cancer-related deaths by 2030. Physical activity and sedentary behaviors have been linked to cancer risk and survival. However, there is limited research on their correlation with pancreatic cancer. To investigate this, we used a Mendelian randomization approach to examine the genetic predisposition to physical activity and sedentariness and their relation to pancreatic cancer risk, while excluding external confounders. Our findings revealed a causal link between the time spent watching television and an increased risk of pancreatic cancer. Additionally, we determined that over half of the effect of watching television on pancreatic risk is mediated by the individual's BMI.
Smad4 restricts injury-provoked biliary proliferation and carcinogenesis
Authors: Alexander William B. , Wang Wenjia , Hill Margaret A. , O'Dell Michael R. , Ruffolo Luis I. , Guo Bing , Jackson Katherine M. , Ullman Nicholas , Friedland Scott C. , McCall Matthew N. , Patel Ankit , Figueroa-Guilliani Nathania , Georger Mary , Belt Brian A. , Whitney-Miller Christa L. , Linehan David C. , Murphy Patrick J. , Hezel Aram F.
Published: February 2024

Cholangiocarcinoma (CCA) is a deadly and heterogeneous type of cancer characterized by a spectrum of epidemiologic associations as well as genetic and epigenetic alterations. We seek to understand how these features inter-relate in the earliest phase of cancer development and through the course of disease progression. For this, we studied murine models of liver injury integrating the most commonly occurring gene mutations of CCA – including Kras, Tp53, Arid1a and Smad4 – as well as murine hepatobiliary cancer models and derived primary cell lines based on these mutations. Among commonly mutated genes in CCA, we found that Smad4 functions uniquely to restrict reactive cholangiocyte expansion to liver injury through restraint of the proliferative response. Inactivation of Smad4 accelerates carcinogenesis, provoking pre-neoplastic biliary lesions and CCA development in an injury setting. Expression analyses of Smad4-perturbed reactive cholangiocytes and CCA lines demonstrated shared enriched pathways, including cell-cycle regulation, MYC signaling and oxidative phosphorylation, suggesting that Smad4 may act via these mechanisms to regulate cholangiocyte proliferation and progression to CCA. Overall, we showed that TGFβ/SMAD4 signaling serves as a critical barrier restraining cholangiocyte expansion and malignant transformation in states of biliary injury.
Molecular survey of certain protozoan agents that cause diarrhea in children in Sudan
Authors: Adam Mosab , Shen Hongwei , Enan Khalid-A , Wang Hao , Musa Azza B. Musa , El Hussein Abdel R. , Khidir Isam M. , Ma Xuejun
Published: February 2024

Introduction Diarrhea is a significant health problem in Third World. Identification the pathogen that cause diarrhea is vital for measures to prevent and control this disease. There are also very few reports of diarrhea in Sudan. Our study aimed to determine the Prevalenceof specific protozoan pathogens (Entameobia histolytica, Cryptosporidium parvum., and Giardia lamblia) in children in Khartoum, Sudan. Methods We conducted a cross-sectional survey among children under five years of age hospitalized with acute diarrhea between April and December 2014. Diarrheastool samples were collected and examined E. histolytica, C. parvum, and G. lamblia using a multiplex real-time PCR. Results 437 acute children were included in this study; the higher Prevalence of diarrhea was in the age less than ≤2years old (403,92.2%). The male-to -female ratio in this study was 1:1.7. infection with intestinal parasite was found in 155 (35.5%) cases, and co-infection was detected in 16 (3.7%) cases. G. lamblia (18.8%) and C. parvum (15.8 %) were the most frequently identified parasites, followed by E. histolytica (0.9). The parasite infection rate was highest and lowest in the under 2-year-old group (32.7%), and in the 2–4-year-old group (2.7%),the infection rate was higher was higher in boys (23.7%) than in girls (11.7%). tThe incidence of protozoan infection was higher (37.7%) in the rainy season (August to December) (32.7%), corresponding with that in the dry Season (April to June). (2.7%) Discussion Our present study demonstrated the high prevalence of G. lamblia and C. parvum in children with diarrhea in Khartoum region and usefulness of the multiplex real-time method in disclosing pathogenic protozoal agents. Our result highlighted the necessity of developing intervention measurement and control strategies to deal with childhood parasitic diarrhea in this region.
Effects of Consumer Dispositional Attitude on Purchase Intention in an Emerging Market
Authors: Shanbhogue A. Venugopal , Ranjith V. K.
Published: February 2024

Background Globalization trends have compelled multinational companies to change their marketing approach from multi-domestic marketing to global marketing. This strategy has had a major impact on the branding of companies. Due to these efforts by international companies, there has been a negative impact on local brands. Strong local brands always maintained the advantage of a high level of awareness among consumers, due to consumers’ close relationship with these brands, hence this resulted in strong and positive marketing investments in the home market. The purpose of this research is to evaluate the attitudinal dispositions towards global and local brands and purchase intention. The objective is to understand the underlying motives of consumers’ purchase decision. Methods Consumer disposition and attitude towards brands are evaluated based on respondents’ purchase intention of a select brand. Data are collected from Bangalore and Chennai using the convenience sampling method. Evaluation of the measurement model was performed using the Smart PLS 4 software. Results Findings suggest that consumer attitudinal disposition has a significant impact on consumers’ purchase intention. Attitude formation is the first step in consumers’ behavioural decision and making a purchase decision. Marketing managers/practitioners need to focus on forming this attitude in consumers’ minds, so that this attitude formation leads to a purchase decision. Conclusions This research provides theoretical and managerial implications for marketers, especially those operating in an emerging market like India as this study has examined the role of consumer disposition on attitude formation and purchase intention. From a theoretical perspective, this study developed and tested a conceptual model describing the relationship between attitudinal disposition and purchase intention.
The impact of anti-COVID measures on accommodation performance
Authors: Šťastná Milada , Ryglová Kateřina , Vaishar Antonín , Králíková Andrea
Published: February 2024

Background This article analyses mass accommodation facilities to examine the development of Czech tourism during the COVID-19 pandemic of 2020 and 2021. Methods The questionnaire survey was carried out in March 2021 in mass accommodation facilities. 131 responses were received from hotels and guesthouses throughout Czechia, which represents a return rate of 20%. Data were processed using Pearson's chi-square test to determine the effect of changes in facility type and category, quality, location, and primary focus before the outbreak of the pandemic. A statistical analysis of data on overnight stays was also used with data from the public database of the Czech Statistical Office. Results The study confirmed the increasing importance of domestic tourism and the greater sensitivity of destinations dependent on foreign tourists. Future strategies should be associated with destination rather than corporate management. The challenges are linked to the strengthening of environmentally friendly and sustainable tourism. To what extent the post-covid situation will return to the original model and to what extent it will at least partially reflect the changes that took place during the crisis period is a question for future research. Conclusions Moving from operational to strategic measures would be advisable.
Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Authors: Nakijoba Ritah , Nakayiwa Kawuma Aida , Ojara Francis Williams , Tabwenda Jovia C. , Kyeyune Jacqueline , Turyamureba Christine , Peter Asiimwe Simon , Magoola Johnson , Castelnuovo Barbara , Buzibye Allan , Waitt Catriona
Published: February 2024

Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure of the breastfed infant to drugs and any related risks are sparce. Lactation studies are only rarely performed close to licensing for medicines anticipated to be widely used in women of childbearing age. Medicines taken by breastfeeding mothers on tuberculosis (TB) treatment can be transferred to the breastfed infant. Potential effects of anti-tuberculosis medicines on nursing infants are not well understood. Similarly, women face mental health challenges whilst taking medications, including postpartum depression, hence the need to assess the psychological behavior of a breastfeeding woman. Potential risks are the development of adverse drug effects in the breastfed infant and selection for resistance, whereas potential benefits might include exposure to potentially prophylactic concentrations of the drug. Pharmacokinetic studies are therefore necessary to understand this situation fully. Methods This study will enroll 20 mothers receiving first-line anti-tuberculosis medicines, together with their breastfed infants, with the aim of characterizing the breastmilk transfer of the medicines from the mother to the infants. Samples of maternal blood, breastmilk and breastfeeding infant’s blood will be obtained at specific time points for bioanalysis of drug concentrations. Pharmacokinetic data will be analyzed using a population pharmacokinetic approach. Additionally, the study will assess the psychological status of breastfeeding women and the well-being of their infants. Maternal depression is linked to long-term negative consequences for the infant’s physiological regulation, poor growth-promoting setting for the infants, and inappropriate interactive conduct, characterized by low compassion, constrained range of emotional expression, and varying provision of the infant’s budding engagement. Conclusions This study will provide the first systematic characterization of mother-to-infant transfer of first-line anti-tuberculosis medicines through breast milk. A mathematical pharmacokinetics model characterizing plasma-to-breastmilk transfer of rifampicin, isoniazid, ethambutol, and pyrazinamide will be developed and used to characterize infant exposure through breast milk. Our findings will contribute towards treatment optimization in breastfeeding and provide a framework to foster other lactation pharmacokinetic studies.
The Competency Pipeline: Examining the Association of Doctoral Training with Early Career Outcomes
Authors:   , Ortiz Andrea
Published: February 2024

Participants from earlier nationwide studies on predictors of internship match were contacted 7-10 years after obtaining their doctoral degree to gather additional data concerning their attained early career competencies and benchmarks (e.g., scores on the national licensing exam). In this sample (N = 190), licensure exam scores were significantly positively associated with scores obtained on the Graduate Record Examination (GRE), family of origin socioeconomic status, and student debt load. However, obtained licensure scores were not found to be significantly associated with any pre-doctoral training variables (e.g., intervention/ assessment hours, number of integrated reports, number of publications, rank order of matched internship site) or most post-doctoral early career activities. Weak positive associations between licensures scores and engaging in teaching / supervision / consultation services were observed. Few self-reported early career competencies were found to be weakly positively associated with scores on the national licensing exam (i.e., integrity, seeking supervision, scientific mindedness, evidence-based practice). Significantly inverse associations were found between national licensing exam scores and self-reported competencies in the areas of management and systems change. Findings are discussed and implications for the national licensing exam considered.
Development and Preliminary Validation of the Comprehensive Trauma and Stressors Checklist
Authors:   , Kemble Lauren Alicia
Published: February 2024

To assess a wide range of stressors and traumas, we developed a trauma and stressors exposure checklist for adults to capture a wide variety of potential trauma exposure. This study details the extensive development and validation process of the Comprehensive Trauma and Stressors Checklist (CTSC). Study 1 consisted of item pool generation, review of existing trauma measures, content analysis, and expert review and input. Study 2 analyzed reliability and validity of the updated checklist. Participants were recruited from college and community samples (N = 200) and completed the CTSC along with five additional measures. The CTSC demonstrated high internal consistency (α =.96). Good temporal stability was established with a subset of participants (n = 28) who completed the survey twice for test-retest reliability (r = 0.86, p < .001). Significant correlations between scores on the CTSC and the Stressful Life Events Screening Questionnaire, Life Events Checklist for the DSM-5, Intersectional Discrimination Index, and Spiritual Abuse Questionnaire are evidence of strong convergent validity. Finally, the lack of significant correlations between CTSC scores and theoretically unrelated constructs supported the discriminant validity of the CTSC. This study provides preliminary evidence that the CTSC is a reliable and valid measure of exposure to traumas and stressors. Future studies with the CTSC will examine measurement invariance, exploratory and confirmatory factor analysis, and reading level.
"The Just For Fun Talent Show"
Authors:   , Bratcher Jordan
Published: February 2024

Three individuals prepare themselves to perform unique talents on a live stage, proving to themselves and others that they are far more capable than they imagined.
An Analytical Study of the Suite for Violin and Piano (1935), Op. 6, by Benjamin Britten (1913-1976)
Authors:   , Lee Hanjun
Published: February 2024

The Suite for Violin and Piano, Op. 6 is one of the least-known compositions by Benjamin Britten. It has been considered unfavorably by critics and scholars due to its puzzling mixture of tonal and post-tonal elements. However, this dissertation argues that the suite is composed with a clear tonal framework, and its unique mixed tonal-post-tonal language justifies an in-depth analysis. This analytical study utilizes a linear progression technique - the voice leading produced by passing tones and neighbor notes around focal pitches - to identify tonal areas of the suite.
Conditional Disclosure of Secrets and Storage over Graphs
Authors:   , Li Zhou
Published: February 2024

In the era of big data, it is essential to implement practical security and privacy measures to ensure the lawful use of data and provide users with trust and assurance. In the dissertation, I address this issue through several key steps. Firstly, I delve into the problem of conditional secret disclosure, representing it using graphs to determine the most efficient approach for storing and disclosing secrets. Secondly, I extend the conditional disclosure of secrets problem from a single secret to multiple secrets and from a bipartite graph to an arbitrary graph. Thirdly, I remove security constraints to observe how they affect the efficiency of storage and recovery. In our final paper, I explore the secure summation problem, aiming to determine the capacity of total noise. Throughout the dissertation, I leverage information-theoretic tools to address security and privacy concerns.
Leadership Practices and Processes that Close Opportunity Gaps for Socioeconomically Disadvantaged and Minoritized Students: A Case Study of a High-Needs Title 1 Elementary School
Authors:   , Braveboy Peter
Published: February 2024

The purpose of this qualitative, single case study was to identify leadership practices and processes that contributed to the success of a single High Needs, Title 1 elementary school that has experienced acknowledged superior academic success, particularly for its minoritized and low socioeconomically disadvantaged students, as indicated by the school's success on the State of Texas Assessment of Academic Readiness (STAAR) tests. The study sought to explore the principal's and teachers' conception of leadership for success and to examine what effective practices and processes were employed at a high-needs, high-performing campus that accounted for its success. The study applied the culturally responsive school leadership (CRSL) framework to analyze the practices employed at the school. Results of the study, from interviews with the principal and a focus group of three teachers, indicated that not only did they apply the principles of the CRSL framework, which employed the critical self awareness, culturally responsive curricula and teacher preparation in a culturally responsive and inclusive school environment which engaged parents and students in community contexts, but they also enhanced their effectiveness through the provision of additional resources for teachers and students, with a heavy reliance on data to guide academic decisions.
California Public Schools and Employees' Negligence of Supervision on School Property
Authors:   , Gonzales Manuel Salas
Published: February 2024

We live in a culture where school systems are accused of being negligent or at fault for any undesired outcome. This can leave school districts and their employees anxious about potential consequences, regardless if the negligent claim is warranted or not. Therefore, there is a need for all educators to understand their responsibilities to provide a safe learning environment, and this may look different from state to state across the United States. The purpose of this study was to analyze how California state courts have interpreted the concept of sovereign immunity and tort claims filed against California public-school districts and their public-school employees related to negligence of supervision on school grounds. This legal research case study design was guided by the following research question: what are the exceptions to sovereign immunity regarding negligence related to the supervision of students as required by California statute? This study analyzed twelve various cases of California public-school districts and employees involving negligence in supervision claims on school grounds after the 1963 California Tort Claims Act was enacted. Based on the issue, rule, application, and conclusion of the twelve cases, eight were ruled in favor of the plaintiff or appellant, and four cases had final court decisions in favor of the defendant or district being sued. Recommendations for further research are to replicate this study to determine how other states interpret negligence of supervision on school property for comparative purposes. Secondly, the research could be expanded to examine the supervision of students while off school premises.
Nitrogen Reduction Reaction: Deposition, Characterization and Selectivity of Transition Metal (V, Co and Ti) Oxynitrides as Electrocatalysts
Authors:   , Chukwunenye Precious O.
Published: February 2024

The electrocatalytic nitrogen reduction reaction (NRR) is of considerable interest due to its potential for less energy intensive and environmentally friendly ammonia production which is critical for agricultural and clean energy applications. However, the selectivity of NRR compared to the hydrogen evolution reaction (HER) often poses challenges for various catalysts, including Earth-abundant transition metal oxynitrides like Ti, V, and Co. In this work, a comparative analysis of the selectivity of these three metal oxynitrides was conducted, each having different metal oxophilicities. A combination of electrochemical, surface characterizations and density functional theory (DFT) calculations were employed to directly assess NRR and HER activities under the same reaction conditions. Results show that cobalt oxynitrides exhibit NRR activity at pH 10, involving the electrochemical reduction of both lattice-bound nitrogen and dissolved N2, although more HER activity was observed. In contrast, vanadium oxynitride films displayed HER inactivity at pH 7 and 10 but demonstrated NRR activity at pH 7, while titanium oxynitrides were active at pH 3.2 but inactive under neutral and basic pH conditions. These comprehensive studies highlight substantial variations in HER and NRR selectivity based on transition metal oxophilicity/azaphilicity, indicating distinct mechanisms governing NRR and HER mechanisms.
Surface Engineering of Materials for Beyond-Microelectronics
Authors:   , Anwar Fatima
Published: February 2024

All oxide heterostructure Cr2O3/TiO2-x was deposited on Al2O3(0001) single crystal via MBE. The analysis of interfacial interactions involving two metal oxides resulting in magnetic properties gave insights for using such heterostructures as potential spintronic device materials. The corundum phase epitaxial growth of TiO2-x on Al2O3 was characterized using XPS, AES, EELS, and LEED. The data obtained gives evidence of presence of two-dimensional electron gas at titania surface due to oxygen vacancies formation after deposition. On titania, the deposition of chrome in UHV results in the formation of oxidized chromia overlayer by abstraction of oxygen from the TiO2-x underlayer further increasing the number of vacancies present. In industrial R&D project, dry etching of multiple optical device components was performed using a novel angled etch prototype tool. The first set of experiments involved plasma etching of SiC thin films optimized for target application. The best-known method (BKM) worked from 300mm full wafer to 200mm product. In second experimentation, a variety of gray-tone photoresist received from customers were etched using BKM. Customer received etch rate on each gray-tone material. The third experiments compared recipe R1 to test recipe R2 on the test vehicle VDC. R2 showed faster etch rate but lower process repeatability (RMSE%). With continuous improvement of the tool and the process, two tools are operating products every day, a third prototype tool is about to be in pilot production.