bluuebunny/crossref_metadata_2025 huggingface dataset:
BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors
Authors: Petrelli Annalisa , Rizzolio Sabrina , Pietrantonio Filippo , Bellomo Sara E. , Benelli Matteo , De Cecco Loris , Romagnoli Dario , Berrino Enrico , Orrù Claudia , Ribisi Salvatore , Moya-Rull Daniel , Migliore Cristina , Conticelli Daniela , Maina Irene M. , Puliga Elisabetta , Serra Violeta , Pellegrino Benedetta , Llop-Guevara Alba , Musolino Antonino , Siena Salvatore , Sartore-Bianchi Andrea , Prisciandaro Michele , Morano Federica , Antista Maria , Fumagalli Uberto , De Manzoni Giovanni , Degiuli Maurizio , Baiocchi Gian Luca , Amisano Marco F. , Ferrero Alessandro , Marchiò Caterina , Corso Simona , Giordano Silvia
Published: May 2023

Despite negative results of clinical trials conducted on the overall population of patients with gastric cancer, PARP inhibitor (PARPi) therapeutic strategy still might represent a window of opportunity for a subpopulation of patients with gastric cancer. An estimated 7% to 12% of gastric cancers exhibit a mutational signature associated with homologous recombination (HR) failure, suggesting that these patients could potentially benefit from PARPis. To analyze responsiveness of gastric cancer to PARPi, we exploited a gastroesophageal adenocarcinoma (GEA) platform of patient-derived xenografts (PDX) and PDX-derived primary cells and selected 10 PDXs with loss-of-function mutations in HR pathway genes. Cell viability assays and preclinical trials showed that olaparib treatment was effective in PDXs harboring BRCA2 germline mutations and somatic inactivation of the second allele. Olaparib responsive tumors were sensitive to oxaliplatin as well. Evaluation of HR deficiency (HRD) and mutational signatures efficiently stratified responder and nonresponder PDXs. A retrospective analysis on 57 patients with GEA showed that BRCA2 inactivating variants were associated with longer progression-free survival upon platinum-based regimens. Five of 7 patients with BRCA2 germline mutations carried the p.K3326* variant, classified as “benign.” However, familial history of cancer, the absence of RAD51 foci in tumor cells, and a high HRD score suggest a deleterious effect of this mutation in gastric cancer. In conclusion, PARPis could represent an effective therapeutic option for BRCA2-mutated and/or high HRD score patients with GEA, including patients with familial intestinal gastric cancer.

Significance:

PARP inhibition is a potential strategy for treating patients with gastric cancer with mutated BRCA2 or homologous repair deficiency, including patients with familial intestinal gastric cancer, for whom BRCA2 germline testing should be recommended.
Updated Review of Major Cancer Risk Factors and Screening Test use in the United States, with a Focus on Changes During the COVID-19 Pandemic
Authors: Star Jessica , Bandi Priti , Nargis Nigar , Islami Farhad , Yabroff K. Robin , Minihan Adair K. , Smith Robert A. , Jemal Ahmedin
Published: May 2023

We present national and state representative prevalence estimates of modifiable cancer risk factors, preventive behaviors and services, and screening, with a focus on changes during the COVID-19 pandemic. Between 2019 and 2021, current smoking, physical inactivity, and heavy alcohol consumption declined, and human papillomavirus vaccination and stool testing for colorectal cancer screening uptake increased. In contrast, obesity prevalence increased, while fruit consumption and cervical cancer screening declined during the same timeframe. Favorable and unfavorable trends were evident during the second year of the COVID-19 pandemic that must be monitored as more years of consistent data are collected. Yet disparities by racial/ethnic and socioeconomic status persisted, highlighting the continued need for interventions to address suboptimal levels among these population subgroups.
Supplementary Table S1: Recruiting TIL trials for patients with non-melanoma solid cancers from TIL Therapy: Facts and Hopes
Authors: Monberg Tine J. , Borch Troels H. , Svane Inge M. , Donia Marco
Published: May 2023

Table S1 shows recruiting TIL trials for patients with non-melanoma solid cancers
Supplementary Table S2 from Clinical Relevance of BRCA1 Promoter Methylation Testing in Patients with Ovarian Cancer
Authors: Blanc-Durand Félix , Tang Roseline , Pommier Margaux , Nashvi Marzieh , Cotteret Sophie , Genestie Catherine , Le Formal Audrey , Pautier Patricia , Michels Judith , Kfoury Maria , Hervé Robert , Mengue Sylvie , Wafo Estelle , Elies Antoine , Miailhe Gregoire , Uzan Jennifer , Rouleau Etienne , Leary Alexandra
Published: May 2023

Clinical data and outcomes of patients included
Supplementary Table S6 from DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
Authors: Tawk Bouchra , Rein Katrin , Schwager Christian , Knoll Maximilian , Wirkner Ute , Hörner-Rieber Juliane , Liermann Jakob , Kurth Ina , Balermpas Panagiotis , Rödel Claus , Linge Annett , Löck Steffen , Lohaus Fabian , Tinhofer Ingeborg , Krause Mechtild , Stuschke Martin , Grosu Anca Ligia , Zips Daniel , Combs Stephanie E. , Belka Claus , Stenzinger Albrecht , Herold-Mende Christel , Baumann Michael , Schirmacher Peter , Debus Jürgen , Abdollahi Amir
Published: May 2023

Supplementary Table S6. Contingency Table of Hypoxia-M and CD8-immunohistochemistry (IHC) staining for CD8-T cells
Supplementary Table S1 from Clinical Relevance of BRCA1 Promoter Methylation Testing in Patients with Ovarian Cancer
Authors: Blanc-Durand Félix , Tang Roseline , Pommier Margaux , Nashvi Marzieh , Cotteret Sophie , Genestie Catherine , Le Formal Audrey , Pautier Patricia , Michels Judith , Kfoury Maria , Hervé Robert , Mengue Sylvie , Wafo Estelle , Elies Antoine , Miailhe Gregoire , Uzan Jennifer , Rouleau Etienne , Leary Alexandra
Published: May 2023

Primer sequences for methylation analysis (methylation-specific ddPCR)
Supplementary Methods S1 from DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
Authors: Tawk Bouchra , Rein Katrin , Schwager Christian , Knoll Maximilian , Wirkner Ute , Hörner-Rieber Juliane , Liermann Jakob , Kurth Ina , Balermpas Panagiotis , Rödel Claus , Linge Annett , Löck Steffen , Lohaus Fabian , Tinhofer Ingeborg , Krause Mechtild , Stuschke Martin , Grosu Anca Ligia , Zips Daniel , Combs Stephanie E. , Belka Claus , Stenzinger Albrecht , Herold-Mende Christel , Baumann Michael , Schirmacher Peter , Debus Jürgen , Abdollahi Amir
Published: May 2023

Supplementary Methods, Results, Table of Contents
Supplementary Appendix S1 from DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
Authors: Tawk Bouchra , Rein Katrin , Schwager Christian , Knoll Maximilian , Wirkner Ute , Hörner-Rieber Juliane , Liermann Jakob , Kurth Ina , Balermpas Panagiotis , Rödel Claus , Linge Annett , Löck Steffen , Lohaus Fabian , Tinhofer Ingeborg , Krause Mechtild , Stuschke Martin , Grosu Anca Ligia , Zips Daniel , Combs Stephanie E. , Belka Claus , Stenzinger Albrecht , Herold-Mende Christel , Baumann Michael , Schirmacher Peter , Debus Jürgen , Abdollahi Amir
Published: May 2023

Statistical Output
Data from The Negative Influence of Baseline Cell-free DNA on Long-term Survival in DLBCL Depends on Frontline Treatment Intensity
Authors: Desmots Fabienne , Rossille Delphine , Roussel Mikael , Pangault Céline , Louarn Laetitia , De Saint Jore Mylène , Le Gouill Steven , Bouabdallah Krimo , Delwail Vincent , Gressin Remy , Cornillon Jérôme , Damaj Gandhi , Maisonneuve Hervé , Damotte Diane , Kraeber-Bodere Françoise , Lamy Thierry , Parrens Marie-Cécile , Milpied Noël , Fest Thierry
Published: May 2023

AbstractPurpose:
This study aims to investigate the relationship between the intensity of the initial treatment given to patients with de novo diffuse large B-cell lymphoma (DLBCL) and the impact of their baseline cell-free DNA (cfDNA) levels on their long-term survival.
Experimental Design:
The GOELAMS 075 randomized clinical trial compared rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) with high-dose R-chemotherapy plus autologous stem cell transplantation (R-HDT) for patients aged ≤60. An interim PET assessment was used to refer patients for salvage therapy. With a median follow-up of more than 5.8 years, we analyzed the effects of the treatment arm, salvage therapy, and cfDNA level at diagnosis on overall survival (OS).
Results:
In a representative group of 123 patients, a high cfDNA concentration (>55 ng/mL) at diagnosis was associated with poor clinical prognostic factors and constituted a prognostic marker, independently of the age-adjusted International Prognostic Index. A cfDNA level above a threshold value of 55 ng/mL at diagnosis was associated with significantly worse OS. In an intention-to-treat analysis, high-cfDNA R-CHOP patients (but not high-cfDNA R-HDT patients) had worse OS [HR (95% confidence interval), 3.99 (1.98–10.74); P = 0.006]. In patients with high cfDNA levels, salvage therapy and transplantation were associated with a significantly higher OS rate. Among 50 patients with complete response 6 months after the end of treatment, for 11 of 24 R-CHOP patients, the cfDNA did not fall back to normal values.
Conclusions:
In this randomized clinical trial, intensive regimens mitigated the negative influence of high cfDNA levels in de novo DLBCL, relative to R-CHOP.
Monitoring Sarcoma Response to Immune Checkpoint Inhibition and Local Cryotherapy with Circulating Tumor DNA Analysis
Authors: Bui Nam Q. , Nemat-Gorgani Neda , Subramanian Ajay , Torres Ileana A. , Lohman Marta , Sears Timothy J. , van de Rijn Matt , Charville Gregory W. , Becker Hans-Christoph , Wang David S. , Hwang Gloria L. , Ganjoo Kristen N. , Moding Everett J.
Published: May 2023

Purpose:

Immune checkpoint inhibition has led to promising responses in soft tissue sarcomas (STS), but the majority of patients do not respond and biomarkers of response will be crucial. Local ablative therapies may augment systemic responses to immunotherapy. We evaluated circulating tumor DNA (ctDNA) as a biomarker of response in patients treated on a trial combining immunotherapy with local cryotherapy for advanced STS.

Patients and Methods:

We enrolled 30 patients with unresectable or metastatic STS to a phase II clinical trial. Patients received ipilimumab and nivolumab for four doses followed by nivolumab alone with cryoablation performed between cycles 1 and 2. The primary endpoint was objective response rate (ORR) by 14 weeks. Personalized ctDNA analysis using bespoke panels was performed on blood samples collected prior to each immunotherapy cycle.

Results:

ctDNA was detected in at least one sample for 96% of patients. Pretreatment ctDNA allele fraction was negatively associated with treatment response, progression-free survival (PFS), and overall survival (OS). ctDNA increased in 90% of patients from pretreatment to postcryotherapy, and patients with a subsequent decrease in ctDNA or undetectable ctDNA after cryotherapy had significantly better PFS. Of the 27 evaluable patients, the ORR was 4% by RECIST and 11% by irRECIST. Median PFS and OS were 2.7 and 12.0 months, respectively. No new safety signals were observed.

Conclusions:

ctDNA represents a promising biomarker for monitoring response to treatment in patients with advanced STS, warranting future prospective studies. Combining cryotherapy and immune checkpoint inhibitors did not increase the response rate of STS to immunotherapy.
Supplementary notes from The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides
Authors: Bedran Georges , Gasser Hans-Christof , Weke Kenneth , Wang Tongjie , Bedran Dominika , Laird Alexander , Battail Christophe , Zanzotto Fabio Massimo , Pesquita Catia , Axelson Håkan , Rajan Ajitha , Harrison David J. , Palkowski Aleksander , Pawlik Maciej , Parys Maciej , O'Neill J. Robert , Brennan Paul M. , Symeonides Stefan N. , Goodlett David R. , Litchfield Kevin , Fahraeus Robin , Hupp Ted R. , Kote Sachin , Alfaro Javier A.
Published: May 2023

Supplementary notes 1 and 2.
Supplementary legends from The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides
Authors: Bedran Georges , Gasser Hans-Christof , Weke Kenneth , Wang Tongjie , Bedran Dominika , Laird Alexander , Battail Christophe , Zanzotto Fabio Massimo , Pesquita Catia , Axelson Håkan , Rajan Ajitha , Harrison David J. , Palkowski Aleksander , Pawlik Maciej , Parys Maciej , O'Neill J. Robert , Brennan Paul M. , Symeonides Stefan N. , Goodlett David R. , Litchfield Kevin , Fahraeus Robin , Hupp Ted R. , Kote Sachin , Alfaro Javier A.
Published: May 2023

Legends for Supplementary tables, supplementary figures, and supplementary notes.
Supplementary Table 4 from The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides
Authors: Bedran Georges , Gasser Hans-Christof , Weke Kenneth , Wang Tongjie , Bedran Dominika , Laird Alexander , Battail Christophe , Zanzotto Fabio Massimo , Pesquita Catia , Axelson Håkan , Rajan Ajitha , Harrison David J. , Palkowski Aleksander , Pawlik Maciej , Parys Maciej , O'Neill J. Robert , Brennan Paul M. , Symeonides Stefan N. , Goodlett David R. , Litchfield Kevin , Fahraeus Robin , Hupp Ted R. , Kote Sachin , Alfaro Javier A.
Published: May 2023

Comparison data of COD-dipp ncMAPs with 4 other studies.
Supplementary Table 1 from The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides
Authors: Bedran Georges , Gasser Hans-Christof , Weke Kenneth , Wang Tongjie , Bedran Dominika , Laird Alexander , Battail Christophe , Zanzotto Fabio Massimo , Pesquita Catia , Axelson Håkan , Rajan Ajitha , Harrison David J. , Palkowski Aleksander , Pawlik Maciej , Parys Maciej , O'Neill J. Robert , Brennan Paul M. , Symeonides Stefan N. , Goodlett David R. , Litchfield Kevin , Fahraeus Robin , Hupp Ted R. , Kote Sachin , Alfaro Javier A.
Published: May 2023

Datasets and samples considered in this study.
Data from The immunopeptidome from a genomic perspective: Establishing the non-canonical landscape of MHC class I–associated peptides
Authors: Bedran Georges , Gasser Hans-Christof , Weke Kenneth , Wang Tongjie , Bedran Dominika , Laird Alexander , Battail Christophe , Zanzotto Fabio Massimo , Pesquita Catia , Axelson Håkan , Rajan Ajitha , Harrison David J. , Palkowski Aleksander , Pawlik Maciej , Parys Maciej , O'Neill J Robert. , Brennan Paul M. , Symeonides Stefan N. , Goodlett David R. , Litchfield Kevin , Fahraeus Robin , Hupp Ted R. , Kote Sachin , Alfaro Javier A.
Published: May 2023

Abstract
Tumor antigens can emerge through multiple mechanisms, including translation of non-coding genomic regions. This non-canonical category of antigens has recently gained attention; however, our understanding of how they recur within and between cancer types is still in its infancy. Therefore, we developed a proteogenomic pipeline based on deep learning de novo mass spectrometry to enable the discovery of non-canonical MHC-associated peptides (ncMAPs) from non-coding regions. Considering that the emergence of tumor antigens can also involve post-translational modifications, we included an open search component in our pipeline. Leveraging the wealth of mass spectrometry-based immunopeptidomics, we analyzed 26 MHC class I immunopeptidomic studies of 9 different cancer types. We validated the de novo identified ncMAPs, along with the most abundant post-translational modifications, using spectral matching and controlled their false discovery rate (FDR) to 1%. Interestingly, the non-canonical presentation appeared to be 5 times enriched for the A03 HLA supertype, with a projected population coverage of 54.85%. Here, we reveal an atlas of 8,601 ncMAPs with varying levels of cancer selectivity and suggest 17 cancer-selective ncMAPs as attractive targets according to a stringent cutoff. In summary, the combination of the open-source pipeline and the atlas of ncMAPs reported herein could facilitate the identification and screening of ncMAPs as targeting agents for T-cell therapies or vaccine development.
NL-201 Upregulates MHC-I Expression and Intratumoral T-cell Receptor Diversity, and Demonstrates Robust Antitumor Activity as Monotherapy and in Combination with PD-1 Blockade
Authors: Mortales Christie , Dutzar Benjamin , Chen Jerry , Chen Alex , Huard Justin , Walkey Carl , Swanson Ryan
Published: May 2023

Cytokine engineering has shown promise as a means to create novel immunomodulatory agents or to improve upon the therapeutic potential of natural cytokines. NL-201, a de novo, hyperstable, IL2 receptor alpha (IL2Rα)–independent agonist of the receptors for IL2 and IL15, elicits robust preclinical activity in syngeneic murine cancer models, including those resistant to immune checkpoint inhibitors (ICI). Here, we report that NL-201 monotherapy converts ‘cold’ tumor microenvironments (TME) to immunologically ‘hot’ states by driving pro-inflammatory gene expression, enhancing IFNγ-dependent MHC-I expression, and expanding both T-cell number and clonal diversity. In addition, the combination of NL-201 and anti–PD-1 resulted in complementary antitumor activity in the immunologically ‘cold’ and ICI resistant B16F10, EMT6, and Renca syngeneic models. In the B16F10 model, treatment with NL-201 plus anti–PD-1 increased the abundance of CD4+ and CD8+ effector T cells in the TME. These findings reveal an important mechanistic basis for the antitumor activity of NL-201 both as a monotherapy and in combination with PD-1 antagonists, and provide further context for the role of IL2Rα-based signaling in ICI-resistant tumors.
Supplementary Figure S2 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R. , Le Marchand Loïc , Haiman Christopher A. , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: May 2023

Supplementary Figure 2: Surveillance, Epidemiology, and End Results Program stage distribution of bladder cancer cases by race/ethnicity. 0: In situ: noninvasive, intraepithelial; 1: Localized only; 2: Regional by direct extension only; 3: Regional lymph node(s) involved only; 4: Regional by BOTH direct extension AND regional lymph node(s) involved; 5: Regional, NOS; 7: Distant site(s)/lymph node(s) involved; 8: Unknown if extension or metastasis; M: Missing.
FIGURE 2 from Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R. , Le Marchand Loïc , Haiman Christopher A. , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: May 2023

Association between Any T2D and bladder cancer in the multiethnic sample stratified by sex, smoking status, alcohol consumption, and BMI. Models adjusted for pack-years smoked (0, 1–10, 11–20, 21–30, 31–40, >40), alcohol consumption (<1 drink/month, ≤1 drink/day, >1 drinks/day), sex (male, female), number of cigarettes smoked per day among smokers (5 cigarettes or less, 6–10 cigarettes, 11–20, 21–30, 31, or more), race/ethnicity (European American, African American, Japanese American, Latin American, Native Hawaiian), and reproductive factors among females. BMI (kg/m3) and smoking status (ever, never, current) were included as strata variables due to their proportional hazard violation. Categorical birthyear was also included as a strata variable to adjust for possible cohort effects. CI, confidence interval; HR, hazard ratio; P het: P-heterogeneity for likelihood ratio test for difference in association across covariate levels.
A estética da hipermasculinidade: uma alternativa de masculinidade pela arte de Tom of Finland
Authors: Giuffrida Paulo Del Bianco
Published: May 2023

Tom of Finland foi um artista homoerótico que, através de suas obras, impactou fortemente na mudança de representação do homem homossexual, que, no início do século XX, era tido como externo ao gênero masculino, sendo levado ao estado de não pertencimento, nem homem e tampouco mulher. Este artigo propõe uma análise das obras de Tom com intuito de compreender a estética da hipermasculinidade formulada a partir de sua arte, expondo como fato uma incessante política de afirmação da existência homossexual como também masculina e máscula.
Daqueles que dizem o nome
Authors: Borges Laura Faria Porto
Published: May 2023

Conto inspirado em "O Búfalo", de Clarice Lispector.
Adlafia kociolekii sp. nov. (Bacillariophyceae): a new naviculoid diatom from the Eastern Himalayas, India
Authors: RADHAKRISHNAN CHERAN , DAS SUDIPTA KUMAR , WETZEL CARLOS E. , KARTHICK BALASUBRAMANIAN
Published: May 2023

We describe Adlafia kociolekii sp. nov. from aerial habitats in Sikkim, India, a part of the Eastern Himalayas. The species is described based on light and scanning electron microscopic observations. The main diagnostic features include valves are clear elliptical, a narrow axial area at the centre, radiate to convergent striation, and distinctive Voigt discontinuity at both apices. In terms of ultrastructure, the features that identify this species as new are the internally presence of raphe on the elevated sternum, with distal raphe ends distinctly deflected to opposite sides of proximal ends, and distal ends terminating in long and thickened helictoglossae. The species was also recorded from wet walls and freshwater habitats of north-east India, in the present study. The morphological features of the species are compared with other closely similar taxa of Adalfia and other naviculoid genera.
Ceratozamia rosea (Zamiaceae): A new species from the Northern Mountains of Chiapas, Mexico
Authors: GARCÍA GONZÁLEZ JOSÉ , PÉREZ-FARRERA MIGUEL Á. , GUTIÉRREZ-ORTEGA JOSÉ SAID , VOVIDES ANDREW P. , DÍAZ JIMENEZ PEDRO
Published: May 2023

Ceratozamia rosea sp. nov., a new cycad species from the northern mountains of Chiapas, Mexico, is described and compared with its geographically proximal and morphologically similar congeners. Ceratozamia rosea is closely related to the geographically proximal species C. zoquorum, C. becerrae, and C. sancheziae, but easily distinguishable by its purplish-pink (Mexican pink) emerging leaves, a trait unique in the genus. Additionally, C. rosea presents several other qualitative and quantitative traits that are significantly differentiated from each of these species. This new species description suggests that Ceratozamia diversity in Chiapas, Mexico, might be higher than previously thought. Ceratozamia rosea is critically endangered due to over-collecting and habitat destruction.
A new diatom (Surirellaceae: Bacillariophyta) species—Surirella caljoniana sp. nov.—in Göydün Spring, Sivas in Eastern Anatolia, Republic of Türkiye
Authors: SOLAK CÜNEYT NADIR , COCQUYT CHRISTINE , HAMILTON PAUL B. , HOLMES JOE , YILMAZ ELIF , KESBIÇ IŞIL
Published: May 2023

A new species Surirella caljoniana sp. nov. is described from a unique microenvironment in the mountainous region of Türkiye. The taxon was found in a small soda spring which is an important water source for the Kızılırmak River. Surirella caljoniana is similar to Surirella brebissonii Krammer & Lange-Bertalot, S. brebissonii var. kuetzingii Krammer and Lange-Bertalot, S. lacrimula J.D.English, S. neglecta Reichardt and S. subsalsa W.Smith in morphology and shape. Unlike the other taxa, S. caljoniana has an oval-elliptic, slightly heteropolar outline, larger length/width ratio and a narrowly rounded, slightly protracted foot pole. Over the striae, distinct fimbriate silica protrusions are evident and similar to some marine species within the Pinnatae.
Spongillaflies (Neuroptera: Sisyridae) of North America with a key to the larvae and adults
Authors: BOWLES DAVID E.
Published: May 2023

The distributions of the two genera (Climacia and Sisyra) and six species of spongillaflies known to occur in Canada, Mexico and the United States are reviewed and summarized. Several new and significant distribution records are presented for states or provinces in these countries. Species diagnoses and a revised, illustrated key to the third instar larvae and adults of all species are presented.
Description of the larva and pupa of Potamyia phaidra Malicky and Chantaramongkol (Trichoptera: Hydropsychidae) from southern Thailand
Authors: PROMMI TAENG ON , PERMKAM SURAKRAI , SITES ROBERT W.
Published: May 2023

Larvae and pupae of Potamyia phaidra Malicky and Chantaramongkol (Trichoptera: Hydropsychidae) were collected from montane streams in southern Thailand. Pupal identifications were based on genitalic features in common with described adults, and larvae were associated with the pupae. Herein, the final larval instar and pupa are described, diagnosed, and figured.
The “Nuts and Bolts” of Doing Coproduction: Exploring Implementation Decisions in Climate Adaptation Research with Stakeholders
Authors: Clifford K. R. , Henderson J. , McAlear Z. , Dilling L. , Duncan B. , Ehert S. , Arens S. , Page R. , Rick U.
Published: May 2023

Developing local climate adaptation strategies that respond to weather and climate extremes is increasingly salient. Coproducing knowledge and climate adaptation strategies can be an important approach to ensuring that they are context specific, meet community needs, and are deemed usable by local decision-makers. Most of the guidance for coproduction has focused on important, overarching themes and ethical considerations like trust, iteration, and flexibility; these are incredibly valuable, but little attention has been focused on specific, highly consequential research decisions that researchers must make that shape project outcomes. Here, we reflect on our experience in a pilot project coproducing climate adaptation knowledge and strategies in six rural communities. We identify eight questions that researchers coproducing science with communities will need to grapple with when designing and conducting research and discuss some of the related trade-offs of each. Topics include community recruitment, champion selection, participant makeup, geography, clarifying expectations, timing, prioritization, and next steps. The questions are broadly applicable to knowledge coproduction and important especially as greater attention is being given to the ethics of doing this work, the power relations, and the potential risk associated with it. We hope that these questions can guide a dialogue for others and motivate explicit discussions of trade-offs involved in planning research that is coproduced with communities. We call for more of this type of self-reflection and sharing across our research community to deepen our knowledge and hopefully lead to a more rapid improvement in outcomes across the many efforts underway today to cocreate climate knowledge for adaptation.
New Testament Apocrypha: More Noncanonical Scriptures, volume 2: A response to Ronald Charles, Sean Hannan and Mona Tokarek LaFosse
Authors: Burke Tony
Published: May 2023

In a joint session at the 2022 annual meeting of the Canadian Society for Patristic Studies and the Canadian Society of Biblical Studies, Mona Tokarek LaFosse assembled a panel of reviewers to engage with the texts presented in the second volume of New Testament Apocrypha: More Noncanonical Scriptures (Eerdmans, 2020). This article is a response to those papers by Tony Burke, the editor of the volume. The response addresses a number of themes raised by the reviewers, including the selection and arrangement of the texts, their troubling depictions of race and gender, the role of orality in their creation, and how the texts can be used in the classroom.
The Impact of Literacy on COVID-19 Pandemic: An Empirical Analysis on India
Authors: Banerjee Subhanil , Koner Souren , Sharma Disha , Gupta Shilpi
Published: May 2023

The study examines how literacy affects COVID-19. It has considered state-level recovery to the total tested ratio and fully vaccinated-to-population ratio as two dependent variables; on the other hand, the state-wise literacy ratio and population density have been considered as independent variables. The success against COVID-19 in India has been achieved through digital retaliation along with the spread of information regarding social distancing, vaccinations, curfews, and lockdowns. The results reveal that the literacy rate impacts both the dependency ratios in a statistically significant and positive way. Quantification of the impact of literacy on COVID-19 is the most novel and unique.
Modeling Jesus Beyond the Black Square: Perspectives on Allyship, False Hope, and Amplifying Silenced Voices
Authors: Page Cassandra D. , Faulds Bethany , Brown Courtney
Published: May 2023

The Triune God has always championed the cause of those who are oppressed. Jesus’ life, death, resurrection, and ascension display the perfect embodiment of social justice. #BlackOutTuesday was one of the largest online social justice demonstrations to date. The proceeds of #BlackoutTuesday and the overwhelming lack of follow-up action after the event provide a window into current activism and the ways in which historic patterns are still prevalent despite the veneer of increased awareness. While current patterns of activism may commonly stop at a black square, the call of Christ invites his followers to move beyond such performative actions into true anti-racist action. This article aims to apply the integration of psychology and theology to modern-day social justice issues using three perspectives that center allyship, false hope, and amplifying silenced voices through the lens of the impetus for #BlackoutTuesday, its misrepresentation in the media, and its actual impact and fallout.
The Consequences of Legislative Professionalism in U.S. State Legislatures: A Review
Authors: Rocca Michael S. , Krebs Timothy B. , McArthur Dylan
Published: May 2023

As polarization and gridlock continues to grip national politics, Americans are increasingly looking to states to remedy the nation’s most significant challenges. But this was not always the case. Americans are increasingly looking to states to remedy the nation’s most significant challenges. But this was not always the case. In the 1960s, state governments—particularly their legislatures—were in crisis. Few legislatures had the capacity to address the daunting issues that were creating massive political, social, and economic unrest in American states and cities. After decades of reforms to address these issues, and the studies of legislative reform that followed, we can make some conclusions about the consequences of legislative professionalization. The purpose of this paper is to present the key findings from work dedicated to the study of these consequences.
Digitized Patients: Elaborative Tinkering and Knowledge Practices in the Open-source Type 1 Diabetes “Looper Community”
Authors: Jansky Bianca
Published: May 2023

In this article, I explore knowledge practices in increasingly digitized, data-driven, and personalized healthcare settings by empirically focusing on the “looper community” in type 1 diabetes. This community develops and uses open-source automated insulin delivery systems and frequently criticizes slow innovation cycles and data monopolies of commercial device manufacturers. Departing from the literature on patient knowledge, I argue that studying these knowledge practices at the intersection of digitized and personalized health care, open-source innovation, and patient activism calls for an expansion of the theoretical notions of patient knowledge. Empirically I map out three knowledge practices: technical, including maintenance and repair work; recursive, including the building and maintenance of adjunct care and support structures; and methodological, including scientistic forms of self-experimentation. I propose “elaborative tinkering” to foreground the nuances of when and how patients’ different forms of knowledge practices intertwine and when they are kept apart. This approach offers new concepts for understanding what it means to know as patients in spaces of (chronic) self-care, innovation, and activism.
Psychometric Properties of the Turkish Version of the Abiloco: Factor Analysis
Authors: Keskin Esra , Livanelioğlu Ayşe
Published: May 2023

The ABILOCO is a questionnaire measuring mobility in stroke patients. The aim of the study was to evaluate the psychometric properties of the ABILOCO-Turkish. One hundred forty stroke patients were included. Thirteen items were rated according to 3 levels: difficult, easy, and impossible. The construct validity of the ABILOCO-Turkish was investigated using exploratory and confirmatory factor analysis. The reliability of the ABILOCO-Turkish was investigated through internal consistency approaches and test–retest reliability. The ABILOCO-Turkish was compared with the Timed Up & Go (TUG) test and the Berg Balance Scale for validity. The scale was repeated 1 week later for test–retest reliability. The Cronbach’s alpha value calculated was 0.96 and item–total score correlations were between 0.464 and 0.899. The intraclass correlation coefficient (ICC) calculated for test–retest reliability was 0.989. According to the results, the ABILOCO-Turkish is highly correlated with the TUG (r: −0.830, p < 0.001) and the Berg Balance Scale (r: 0.919, p < 0.001). The exploratory factor analysis of the ABILOCO-Turkish showed that it is unidimensional, with this factor explaining 66.56% of the variance, and the construct validity was proven by confirmatory factor analysis. The Turkish version of the ABILOCO is a reliable and valid scale for evaluating mobility in stroke patients.
‘It’s tough. It is hard’: A qualitative interview study of staff and volunteers caring for hospice in-patients with delirium
Authors: Featherstone Imogen , Siddiqi Najma , Jones Lesley , Coppo Eleonora , Sheldon Trevor , Hosie Annmarie , Wolkowski Anna , Bush Shirley H , Taylor Johanna , Teodorczuk Andrew , Johnson Miriam J
Published: May 2023

Background:

Delirium is a distressing condition often experienced by hospice in-patients. Increased understanding of current multidisciplinary care of delirium is needed to develop interventions in this setting.

Aim(s):

To explore hospice staff and volunteers’ practice, its influences and what may need to change to improve hospice delirium care.

Design:

Qualitative interview study using behaviour change theory from a critical realist stance.

Setting/participants:

Thirty-seven staff, including different professional groups and roles, and volunteers were purposively sampled from two in-patient hospices.

Results:

We found that participants’ practice focus was on managing hyperactive symptoms of delirium, through medication use and non-pharmacological strategies. Delirium prevention, early recognition and hypoactive delirium received less attention. Our theoretically-informed analysis identified this focus was influenced by staff and volunteers’ emotional responses to the distress associated with hyperactive symptoms of delirium as well as understanding of delirium prevention, recognition and care, which varied between staff groups. Non-pharmacological delirium management was supported by adequate staffing levels, supportive team working and a culture of person-centred and family-centred care, although behaviours that disrupted the calm hospice environment challenged this.

Conclusions:

Our findings can inform hospice-tailored behaviour change interventions that develop a shared team understanding and engage staff’s emotional responses to improve delirium care. Reflective learning opportunities are needed that increase understanding of the potential to reduce patient distress through prevention and early recognition of delirium, as well as person-centred management. Organisational support for adequate, flexible staffing levels and supportive team working is required to support person-centred delirium care.
Piaget's 3-mountains task with impossible options: Sighted, blindfolded, early and late blind participants
Authors: Chao Hsin-Yi , Wnuczko Marta , Kennedy John M.
Published: May 2023

In Piaget's 3-mountains task, 3D objects – a cube, cone and sphere – sit on a square tabletop. They are portrayed in 2D pictures as elevations (projections to the sides) such as one with a square on the left, a triangle in the middle and a circle on the right. Three objects offer six elevations, of which four are possible and two impossible. The possibles are elevations from the sides of the table – front, left, right and rear. In the impossibles, an object in the corner of the table is shown in the middle of an elevation. Sighted, sighted-blindfolded, early- and late-blind adults judged the elevations as to side of the table or impossible. The results suggest similar spatial abilities across groups. The impossible options had mid-range accuracy for all groups, with reaction times like possible options. The sighted and blind participants may consider possible and impossible options sequentially, one item at a time.
Cascaded acquisition of spatial contextual cueing
Authors: Lie Kin-Pou
Published: May 2023

Spatial contextual cueing refers to the facilitation of visual search when invariant spatial configurations of the target and distractors are learned. Using the instance theory of automatization and the reverse hierarchy theory of visual perceptual learning, this study explores the acquisition of spatial contextual cueing. The findings support the reverse hierarchy theory, which predicts that the acquisition of spatial contextual cueing progresses in an easy-to-difficult cascading manner. However, these findings are inconsistent with instance theory, which predicts that the acquisition of spatial contextual cueing in easy-half-repeated trials would keep pace with that in difficult-half-repeated trials. This study concludes that compared with instance theory, reverse hierarchy theory more plausibly explains the acquisition of spatial contextual cueing.
The mediational role of individual and organizational factors in the work engagement and occupational stress relationship
Authors: Amankwah Majoreen Osafroadu
Published: May 2023

This study investigated the mediating role of individual and organizational factors on the relationship between work engagement and occupational stress among males and females, junior, mid-level and senior staff members in the banking sector using a cross-sectional survey. Employing a quantitative study, data was gathered from 288 banking staff. Findings show a significant positive relationship between work engagement and age, educational level, one’s position in an organization and organization tenure, and a significant negative relationship between work engagement and gender and occupational stress. There were age, educational level and gender differences in work engagement. There were differences in the level of work engagement in relation to organizational tenure. One’s position, educational level and gender significantly predicted work engagement but age and organization tenure did not. However, educational level, age, one’s position and organizational tenure mediated the relationship between occupational stress and work engagement. These findings have implications for employee well-being and satisfaction and productivity in the organizational setting.
Silicon Savannahs and motorcycle taxis: A Southern perspective on the frontiers of platform urbanism
Authors: Cirolia Liza Rose , Sitas Rike , Pollio Andrea , Sebarenzi Alexis Gatoni , Guma Prince K
Published: May 2023

The rise of digital platforms in urban Africa has been rightfully critiqued as an example of global techno-capital seeking new frontiers of profit among precarious lives and from fragile infrastructures. However, this techno-pessimistic reading of so-called “platform urbanism” leaves us with a bleak outlook on the future of the African city as a mere site of accumulation and exploitation. In this article, in contrast, we offer a more ambivalent analysis of a compelling trend in several African cities: the platformization of motorcycle taxis. Our focus is on Kigali and Nairobi two cities that have been celebrated as “Silicon Savannahs” for their commitment to digital innovation, and where motorcycle taxis have long contributed to the regular movement of people and goods. Deploying a Southern urban perspective on the digitization of these mobility systems, we make two contributions to platform urbanism debates. First, we show that this phenomenon dovetails two decades of supply-side, developmental investments in the connectivity infrastructure upon which platforms rely and are predicated. Second, we show that platform urbanism is not simply a case of global technologies landing in Africa. It is characterized by a proliferation of experiments in which domestic and international capital coalesce, platforms intersect in dynamic ways with informal economies, and local adaptations are necessary for survival. Overall, we argue that the platformization of motorcycles in these cities (and arguably others) constitutes a dynamic and evolving landscape that requires more careful conceptual and empirical attention.
Novel Soft-Computing Approach to Better Predict Flexible Pavement Roughness
Authors: Naseri Hamed , Shokoohi Mohammad , Jahanbakhsh Hamid , Karimi Mohammad M , Waygood E.O.D.
Published: May 2023

Road infrastructures are fundamental parts of peoples’ lives, allowing them to access various destinations and activities. Accordingly, infrastructure should be in an appropriate condition. A pavement maintenance plan should be optimized, and pavement condition should be predicted accurately to obtain optimal pavement maintenance solutions. Therefore, the prediction of pavement conditions with high accuracy has been an immense concern. This study aims to introduce a new approach to accurately predict pavement international roughness index (IRI) over the long term. To this end, all the vital parameters, including initial IRI, pavement age, lane width, traffic loadings, structural characteristics, climatic features, and pavement distresses, are considered. With all the vital parameters, the prediction problem includes 58 variables. Thus, the application of a proper feature-selection technique is vital. To this end, a novel hybrid feature-selection method is introduced by a combination of arithmetic optimization algorithm and stochastic gradient descent regression (AOA-SGDR). Moreover, the performance of the proposed feature-selection method is compared with Lasso and all features. Five machine-learning algorithms, including random forest regression (RFR), support vector machine, multi-layer perceptron, decision-tree regression, and multiple linear regression, are employed for the prediction process. By employing AOA-SGDR, the average testing-data mean absolute error (MAE) reduces by at least 7.92%. Meanwhile, RFR provides the highest accuracy, with average testing-data MAE of 0.095 m/km. Moreover, analyzing the parameters indicates that initial IRI, pavement age, equivalent single axle load (ESAL), and structural number (SN) have the most significant relative influence on IRI.
“The lessons of 9/11 haven’t been learned”: World Trade Center cough syndrome reframed as a national news item during COVID-19 pandemic
Authors: Reed Sada
Published: May 2023

This study is a content analysis of American news coverage of World Trade Center (WTC) cough syndrome, a common ailment among 9/11 survivors, published before and during the COVID-19 pandemic. Before the pandemic, coverage was limited to areas geographically proximate to the attacks and embodied themes of respiratory disease descriptions, heroism and patriotism and government involvement. Pandemic-era coverage expanded to areas where survivors now live and embodied themes of survivors comparing 9/11 to the pandemic, survivors’ vulnerability to COVID-19, lack of federal government transparency, calls for caution and safety protocols, heroism and patriotism and the 9/11 Victim Compensation Fund.
“Don’t Turn a Blind Eye”: An Instruction for Supporting Meaningful Conversations About Gender-Based Violence During Perinatal Care
Authors: Mirlashari Jila , Pederson Ann , Lyons Janet , Brotto Lori A.
Published: May 2023

Background and purpose

Evidence suggests that Gender-based violence (GBV) is prevalent throughout the perinatal period. Women during this time have frequent contact with healthcare providers (HCPs), and there are many opportunities that HCPs can identify GBV and support women by early intervention during routine prenatal care. However, evidence shows that HCPs are still hesitant to address this issue. This study was conducted to explore the experiences of Survivors and HCPs on how to manage a meaningful conversation about GBV with survivors during perinatal care.

Methods

A thematic approach has been used in this qualitative study.

Results

Twenty-eight semi-structured interviews were conducted with survivors and HCPs. Three main themes emerged from the data analysis, including: “Knock gently on the door to enter the client's private world”, “Show interest in clients’ stories that are beyond their physical problems” and “Gradually and cautiously cross the hidden borders.”

Conclusion

HCPs play a pivotal role in identifying GBV and providing support for survivors, particularly during their perinatal period. However, initiating a conversation around this sensitive topic needs time, skill, and enough knowledge. Validating survivors’ experiences, providing a private and safe atmosphere without judgment, and creating empathy could lead to more disclosure of GBV. To have a meaningful conversation, HCPs need to have a holistic approach toward care, show interest in clients’ stories beyond their physical problems, and support clients who have shared sensitive information.
The House That Deconstruction Built: Can Post-Structuralism Inform A Liberatory Social Work Praxis?
Authors: Talarico Giacinta
Published: May 2023

Social work praxis has long been in conversation with feminist praxis and has more recently been informed by an anticolonial feminist praxis that aims to center theorizing, activism, and service delivery around individuals and communities considered “most marginalized.” While this “most marginalized” class may be deemed newly worthy social service consumers this framing reinforces extant settler colonial hierarchies of power and oppression by constituting new classes of “deserving” and “undeserving” social service recipients. This article explores how the feminist organizing, scholarship, and activism of the past decade—specifically around the #MeToo movement and trans-exclusionary radical feminism (TERF) wars—have impacted social work praxis and laid bare the dualistic binds of a post-structuralism that has been consumed and recast within neoliberalism as demobilized identity politics. By examining these limitations, questions are raised regarding next steps for a social work praxis concerned with justice, transformation, and liberation.