bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical manifestations and diagnosis of consequences of traumatic brain injury in children
Authors: Guzeva V. I. , Guzeva V. V. , Guzeva O. V. , Kasumov V. R. , Okhrim I. V. , Orel V. V.
Published: April 2022

In Russia, about 140–160 thousand children are hospitalized annually with a diagnosis of childhood traumatism. Half of the surviving children with severe traumatic brain injury become disabled. Purpose. To perform a comparative analysis of clinical and anamnestic data and neurological disorders in children with traumatic brain injury (TBI). Characteristics of children and research methods. The study involved 81 children with TBI of varying severity. Statistical processing of data was carried out using Student’s test and Fisher’s exact method. Results. The study showed that the duration of the period from the moment of TBI to the hospitalization of children due to post-traumatic complications decreases linearly with increasing age at the time of traumatic brain injury. Mild traumatic brain injury was diagnosed in 47 (58.02%) children, moderate-to-severe — in 16 (19.75%) children, severe traumatic brain injury — in 18 (22.22%) children. The EEG study showed the presence of epileptiform and paroxysmal activity in children not only with moderate and severe, but also mild traumatic brain injury. Post-traumatic epilepsy was diagnosed in 28 (46.67%) children, the risk group for developing post-traumatic epilepsy was 19 (31.67%) children. MRI examination of the brain revealed organic changes in 62.07% of children. Conclusion. A special feature in children is the presence of post-traumatic consequences even after a mild traumatic brain injury. The duration of the period before hospitalization due to post-traumatic consequences in children decreases with increasing age at the time of traumatic brain injury. Focal symptoms in children with severe traumatic brain injury were detected significantly more often than in children with mild and moderate traumatic brain injury.
Optimizing the diet of children with disabilities
Authors: Lugovaya E. A. , Averyanova I. V.
Published: April 2022

Principles of nutrition for disabled children are very important. Russia’s specialized institutions and boarding schools for children with disabilities were monitored and proved to have no specific diet adapted for children with special needs (mental delay, emotional-volitional defects — autistic disorders). According to the World Health Organization (WHO), unbalanced diets along with lifestyle habits are the main risk factors for chronic diseases which can develop and accelerate disorders in intellectual and cognitive abilities. The study analyzed reference data in order to identify and summarize patterns in diets designed for children with special medical care needs. The review assessed works of foreign and domestic authors, as well as data obtained with SRC ‘Arktika,’ on nutrition status of children with disabilities under the north conditions. By meta-analysis, the authors made recommendations for optimizing the diet for children with disabilities.
Wood Texture as An Inspiration for the Creation of Digital Imaging
Authors: Yuwono Budi
Published: April 2022

In the world of design, themes and concepts become fundamental. Themes and concepts cover the whole idea of a work, as well as in the field of digital imaging. Ideas can be taken from nearby environments such as natural beauty of wood texture. The idea used in the creation of digital imaging is wood texture. The process is the pre-production and production stage. Methods consisting of idea stages, data collection, stage of embodiment, and finalization. At the idea stage, it is attempted to visualize and represent the wood texture through digital imaging techniques. This idea was raised based on believes that wood texture has the aesthetic textures to be applied to digital imaging illustration. Data collection is done through observation. While at the stage of embodiment the process carried out is to make editing image through Adobe Photoshop software. Finalization done with export the illustration in JPG format. The result of this creation is an illustrative work resulting from the digital imaging process entitled Dream Land. It is the process of uniting and editing multiple images into one relevant entity.
Evaluation of tear secretion by phenol red thread test in Holstein cows
Authors: SAĞLAM KAMIL , DÜZ ERKAN
Published: April 2022

This study aimed to measure the normal physiological tear production of Holstein cows with the phenol red thread (PRT) test to determine the reference value specific to this test and to examine the effect of the number of births, age and seasonal air temperature on the amount of tear production. The study was performed on 50 Holstein cows aged 3-7 years in two groups. The PRT test was performed in group 1 in January and in group 2 at the end of May. The age and birth numbers of all animals were recorded. The mean amount of tear secretion for all Holstein cows (n = 50) was 32.90 ± 0.73 mm/15 sec. The mean value was 34.47 ± 1.28 mm/15 sec. for group 1 (n = 23) and 31.55 ± 0.73 for group 2 (n = 27). When the seasonal temperature increased from 12°C to 20°C, the difference in the mean amount of tear production between group 1 and group 2 was statistically significant (P <0.05). Although there was a tendency for the amount of tears produced to increase with the increase in the number of births, it was not statistically significant (P > 0.05). Similarly, the decrease in the number of tears with increasing age was not statistically significant (P > 0.05). This study determined reference values for tear secretion in healthy Holstein cows with the PRT test. Higher PRT scores were recorded in winter than in spring (P <0.05), and the change in PRT values was not significant as the number of births and age increased (P > 0.05).
Novel Approaches for the Application of Herbs for Skin Care
Authors: Gautam Rupesh Kumar , Kamal Mohammad Amjad , Chopra Hitesh , Tsagkaris Christos , Matthews Lauren
Published: April 2022

Skin is the largest non–parenchymal organ of the human body. It constitutes a natural
barrier against pathogens and harmful environmental exposures and contributes to the human body's
homeostasis. Conditions affecting the skin range from infections and injury to autoimmune diseases
and cancer. Herbs have been used to treat dermatological conditions for a long time. Traditional
approaches to delivering herbs to the skin include ointments, gels, creams, and lotions. However,
poor lipophilicity or hydrophilicity in most herbal preparations results in limited bioavailability and
poor penetration, restricting their effectiveness. Nanotechnology-based approaches have major potential,
showing more promising results in enhancing transdermal penetration than traditional approaches.
This review article summarizes such advances and sheds light on future directions in using
nanotechnology-based strategies.
When the Mind Comes to Live Inside the Body: The Ontogeny of the Perceptual
Control Clock
Authors: Ferber Sari Goldstein , Geva Ronny , Weller Aron
Published: April 2022

In this editorial, we discuss the neurobiological processes underlying the early emergence
of awareness that we term the “when” and “how” the mind comes to live inside the body. We describe
an accumulative developmental process starting during embryonic life and continuing to fetal
and postnatal development, of coupling of heart rate, body movements, and sleep states on the behavioral
level with underlying mechanisms on the structural, functional, cellular, and molecular levels.
A developmental perspective is proposed based on Perceptual Control Theory (PCT). This includes
a developing sequence of modules starting from early sensing of neural intensities to early
manifestation of human mindful capacities. We also address pharmacological treatments administered
to preterm infants, which may interfere with this development, and highlight the need to consider
this potential “side effect” of current pharmaceuticals when developing novel pharmacogenomic
treatments.
Favorable Aspects of Silymarin in Linezolid Treatment Against Diabetic
Methicillin-Resistant Staphylococcus aureus (MRSA) Infected Rats
Authors: Vivekanandan Lalitha , Singaravel Sengottuvelu , Thangavel Sivakumar
Published: April 2022

Background:

Linezolid used for diabetic methicillin-resistant Staphylococcus aureus (MRSA)
infections is limited due to hepatotoxicity, lactic acidosis, anemia, and oxidative stress induced by diabetes
and linezolid therapy. Silymarin is a hepatoprotective, antioxidant, antibacterial, and antidiabetic.

Objective:

The research investigated the role of silymarin in linezolid treatment against MRSA-infected
diabetic rats.

Methods:

Type 2 diabetes mellitus (T2DM) was induced by a high-fat diet (58% calories fat) for 2 weeks,
followed by a single intraperitoneal injection of streptozotocin (STZ) 35 mg/kg into Wistar rats. The diabetic
rats were rendered neutropenic and subcutaneously injected with 106 CFU/ml of MRSA. Linezolid
and silymarin were administered orally at a dose of 50 mg/kg twice daily for 14 days. The bacterial
load/abscess, hematological, biochemical, enzymatic parameters, antioxidants, and histopathological studies
were performed on the 42nd day.

Results:

The MRSA was confirmed by PCR assay. The minimum inhibitory concentration of linezolid
was found to be 0.5-2 μg/ml. The linezolid treated MRSA infected diabetic rats showed 9.69 x 103 CFU /
abscess bacterial count, decreased intestinal alkaline phosphatase (IAP), RBC, antioxidants, elevated lactate,
and liver markers than diabetic rats. The silymarin treatment showed a decrease in the bacterial count
(2.98 x 103 CFU / abscess), serum lactate, liver markers, increased IAP levels, and antioxidants in linezolid
treated diabetic infected rats.

Conclusion:

The research concluded that silymarin could be a better herbal therapeutic agent that attenuated
diabetic and linezolid induced complications in MRSA-infected diabetic rats.
Medicinal Importance, Pharmacological Activities, and Analytical Aspects
of an Isoflavone Glycoside Tectoridin
Authors: Patel Dinesh Kumar
Published: April 2022

Background:

Polyphenols are a group of secondary plant metabolites produced in
plants as a protective system against oxidative stress, UV radiation, pathogens, and predatorial
attacks. Flavonoids are a major class of plant phenolics present in fruits, vegetables, tea, and red
wine. Tectoridin, also called 40,5,7-thrihydroxy-6-methoxyisoflavone-7-Ob-D-glucopyranoside
is an isoflavone glycoside present in the flower of Porites lobata.

Methods:

Present work focused on the biological importance, therapeutic potential, and pharmacological
activities of tectoridin in medicine. Numerous scientific data have been collected from
different literature databases such as Google Scholar, Science Direct, PubMed, and Scopus to
know the health beneficial potential of tectoridin. Pharmacological data have been analyzed in
the present work to know the biological effectiveness of tectoridin against human disorders. Analytical
data of tectoridin have been collected and analyzed in the present work to know the
importance of modern analytical methods in the isolation, separation, and identification of
tectoridin.

Results:

Scientific data analysis revealed the biological importance and therapeutic benefit of
tectoridin in medicine, signifying the therapeutic potential in healthcare systems. The biological
activities of tectoridin are mainly due to its anti-inflammatory, anti-platelet, anti-angiogenic,
hepatoprotective, anti-tumor, estrogenic, antioxidant, and hypoglycemic activity. However, this
work has also presented the effectiveness of tectoridin against rat lens aldose reductase, nitric oxide,
skeletal and cardiac muscle sarcoplasmic reticulum, and enzymes. Analytical data signified
the importance of modern analytical techniques for separation, identification, and isolation of
tectoridin.

Conclusion:

The present work signified the biological importance and therapeutic benefit of tectoridin
in medicine and other allied health sectors.
Comprehending the Role of Endocrine Disruptors in Inducing Epigenetic
Toxicity
Authors: Kirtana Arikath , Seetharaman Barathi
Published: April 2022

Endocrine disruptors are natural or man-made chemicals that interfere with the body’s
endocrine system leading to hormone synthesis and production defects. These chemicals are
categorized as plasticizers and cosmetic chemicals, heavy metals, phytoestrogens, pesticides,
detergents, surfactants, and flame retardants. Some of the most common endocrine disruptors
are dioxins, bisphenol A, phthalates, perchlorate, perfluoroalkyl, and poly-fluoroalkyl substances
(PFAs), phytoestrogens, polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls
(PCB), triclosan, atrazine, lead, arsenic, mercury, organophosphate pesticides, and glycol
ethers. Epigenetic alterations such as DNA methylation, histone modification, and miRNA
regulation have been observed to play a major role in many diseases such as cancer, neurodegenerative
diseases, PCOS, cardiovascular diseases, and various other disorders. In recent times,
there has been a focus on endocrine-disrupting chemicals in epigenetic alterations. This review
concentrates on estrogen and androgen disrupting effects, placental, and fetal effects, thyroid
disrupting effects, and transgenerational effects of endocrine disruptors.
Mathematical Modelling of a Non-Isothermal Tubular Reactor
Authors: Pal Dipankar , Ghosh Sourav
Published: April 2022

Background:

Tubular reactors have wide applications in various industries, namely,
ammonia synthesis, oil cracking, gasoline production, and sulfur dioxide oxidation to sulfur trioxide.
The most common reactor is the tubular flow reactor. This article aims to study the variation
of outlet concentration and temperature on different parameters, like Reynolds number, Prandtl
number, and Peclet number, which determine the performance and conversion of reactants. This
article shows the temperature and concentration profiles of various parameters.

Methodology:

In the analysis of the first part of the article, a different governing equation of a nonisothermal
tubular flow reactor has been described. The non-dimensionless form of the governing
equations has been derived by applying different boundary conditions. COMSOL Multiphysics
software was used (version -5.6) to solve the coupled governing equations (non-linear PDE).

Results:

The plots of various parameters like Reynolds number, Prandtl number with outlet temperature,
and conversion have been shown. The temperature and concentration profile for certain
conditions are also shown.

Conclusion:

The variation of parameters shows how strongly they depend on the net conversion
of reaction. The thermal effects should be taken care of as the heat of the reaction is very sensitive
to converting and forwarding the reaction. Proper temperatures must be maintained for highly
exothermic reactions; a real-life process is Haber’s process of ammonia production.
Argument structure of transition and transfer verbs
Authors: Ariasih Ni Luh Putu , Sedeng I Nyoman
Published: April 2022

This study entitled Argument Structure of Transition and Transfer Verbs. It focused on the argument structure which maps the grammatical relation and the semantic roles. This study aimed to recognize the grammatical relations of transition and transfer verbs of slides verbs arguments and to explain the semantic roles of transition and transfer verbs of slides verbs arguments. This study is library research. The data of this study were collected from Corpus of Contemporary American English (COCA) which was related to transition and transfer verbs. The documentation method and note-taking technique were applied in collecting the data. In analyzing the data, the descriptive-qualitative method was applied. The data were described and explained based on the theory of argument structure and the theory of transition and transfer verbs. Based on the analysis, the grammatical relation operated within transition and transfer verbs with the class of slide verb involve subject, object and oblique. Verb bounce, float, move, roll and slide can be constructed with SV, SVO, SV OBL, SVO OBL and SVO OBL OBL. Furthermore, the structure SVO OBL OBL only appears in the verb of move.
Developing a Mobile Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events Administration System to Capture Postradiation Toxicity in Oncology: Usability and Feasibility Study (Preprint)
Authors: Underwood Jody , McCloskey Susan , Raldow Ann , Kishan Amar , Zalkin Chad , Navarro Daniel , Holt Lisa Scott , Webb Andrew , Lynch Kathleen A , Atkinson Thomas M
Published: April 2022

BACKGROUND

Accurate self-reported symptomatic toxicity documentation via the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) is essential throughout cancer treatment to ensure safety and understand therapeutic efficacy. However, the capture of accurate toxicities from patients undergoing radiation therapy is challenging because this is generally provided only at the time of scheduled visits.

OBJECTIVE

This study seeks to establish the usability and feasibility of a mobile PRO-CTCAE Administration System (mPROS) to capture toxicities related to radiation therapy.

METHODS

English-speaking adult patients who were undergoing radiation therapy for cancer were enrolled and given a brief demonstration of the Say All Your Symptoms (SAYS) and Symptom Tracking Entry Program (STEP) interfaces of the mPROS app, followed by a patient-use phase where patient actions were observed as they navigated mPROS to enter toxicities. Patient feedback was captured via a semistructured interview and brief questionnaire.

RESULTS

We enrolled 25 patients (age: mean 60.7 years; females: n=13, 52%; White patients: n=13; 52%; non-Hispanic patients: n=19, 76%; college graduates: n=17, 68%). Patients almost equally preferred the SAYS (n=14, 56%) or STEP (n=11, 44%) interfaces, with 21 patients (84%) agreeing that they would use mPROS to report their symptoms to their health care team and 19 patients (76%) agreeing that they would recommend mPROS to others.

CONCLUSIONS

The mPROS app is usable and feasible for facilitating the patient reporting of radiation therapy–related symptomatic toxicities. A revised version of mPROS that incorporates patient input and includes electronic health record integration is being developed and validated as part of a multicenter trial.
Authors’ Response to Peer Reviews of “Modeling Years of Life Lost Due to COVID-19, Socioeconomic Status, and Nonpharmaceutical Interventions: Development of a Prediction Model” (Preprint)
Authors: John Jari
Published: April 2022

UNSTRUCTURED

This is the author response to peer review reports related to MS#30144
Acceptability of Video Observed Treatment vs. Direct Observed Treatment for Tuberculosis: A Comparative Analysis between South and Central India (Preprint)
Authors: Rao Joseph Sushil , Diwan Vishal , Kumar Anil A , Varghese Suman Sarah , Sharma Upasana , Purohit Manju , Das Arundhati , Rodrigues Rashmi
Published: April 2022

BACKGROUND

Direct Observed Treatment (DOT) is a requirement in the management of Tuberculosis (TB) globally. With the transition from alternate day treatment to daily treatment in India, monitoring treatment adherence through DOT is a logistic challenge. The pervasiveness of mobile phones in India therefore provides a unique opportunity to address this challenge remotely.

OBJECTIVE

This study was designed to compare the acceptability of mobile phones for antitubercular treatment (ATT) support in two distinct regions of India.

METHODS

This was a cross sectional exploratory study that enrolled 351 patients with TB, of whom 185 were from Bangalore, Karnataka, South India and 166 from Ujjain, Madhya Pradesh, Central India. Trained research assistants administered a pretested questionnaire comprising demographics, phone usage patterns and acceptability of mobile phone technology to support treatment adherence to TB medicines. The results were statistically analysed.

RESULTS

The mean age of the 351 participants was 32±13.6 years of whom 140 (40%) were women. Of the participants, 259 (74%) were urban, 221 (63%) had >4 years of education. A significantly greater number of participants were newly diagnosed with TB and were in the intensive phase of treatment. Overall, 218 (62%) preferred vDOT over DOT.
There was an overall difference in preference between the two sites which is explained by difference in socio economic variables vDOT

CONCLUSIONS

Mobile phone adherence support is acceptable to patients on Antitubercular treatment ATT with minor variations in design based on demographic and cultural differences. In India, the preference for voice calls over text messages/SMS while designing mHealth interventions cannot be ignored. Of importance is the preference for DOT over vDOT in central India, unlike South India. However, in time, the expanding use of mobile technology supplemented with counselling, could overcome the barriers of privacy and stigma and promote the transition from in-person DOT to vDOT or mobile phone adherence monitoring and support for ATT in India.

CLINICALTRIAL

CTRI/2017/07/009052
Effectiveness of Virtual Reality in Symptom Management of Cancer Patients：A Systematic Review and Meta-Analysis (Preprint)
Authors: Wu Yuan , Wang Nannan , Zhang Huichao , Zhang Yuxi
Published: April 2022

BACKGROUND

Although the survival rate of cancer patients has been increasing, such patients often experience severe physical and psychological burdens due to the effects of the disease itself and therapy. Multiple virtual reality (VR)-based interventions have been used to help improve physical and psychological symptoms and quality of life in cancer patients.

OBJECTIVE

This study aimed to assess the effects of VR-based interventions on anxiety, pain, depression, fatigue, fear, distress, and quality of life in cancer patients.

METHODS

We conducted comprehensive searches in the PubMed, Web of Science, CINAHL, EMBASE, Cochrane Library, Scopus and APA PsycINFO databases from their inception to 12 July 2022. Two reviewers independently selected studies and extracted articles that met strict inclusion and exclusion criteria. Quality assessments of the included studies were performed according to the Cochrane risk assessment tool, and data analysis was performed using RevMan 5.4 software.

RESULTS

A total of 20 studies were included in this review, and 15 (75%) were selected for meta-analysis. The results showed a significant difference between the VR and control groups for anxiety (standard mean difference [SMD] =−1.01, 95% CI −1.55 to −0.48, P<0.001), pain (SMD= −0.80, 95% CI −1.27 to −0.32, P<0.001), depression (SMD=−1.78, 95% CI −3.26 to −0.30, P=0.02), fear (MD=−0.82, 95% CI −1.60 to −0.03, P=0.04), distress (SMD=−1.16, 95% CI −1.96 to −0.37, P=0.004), and fatigue (SMD=−2.47, 95% CI −2.92 to −2.02, P<0.001). However, no significant difference was observed in quality of life (SMD=1.01, 95% CI −0.67 to 2.70, P=0.24).

CONCLUSIONS

VR interventions were effective in improving physical and psychological symptoms in cancer patients. Due to the limited number of studies, small sample sizes, and moderate to high heterogeneity, these results should be interpreted with caution. More rigorous, comprehensive and high-quality randomized controlled trials (RCTs) are needed to validate the results of this study.

CLINICALTRIAL

PROSPERO International Prospective Register of Systematic Reviews CRD42022304931；https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=304931
Correction: Mining Electronic Health Records for Drugs Associated With 28-day Mortality in COVID-19: Pharmacopoeia-wide Association Study (PharmWAS) (Preprint)
Authors: Lerner Ivan , Serret-Larmande Arnaud , Rance Bastien , Garcelon Nicolas , Burgun Anita , Chouchana Laurent , Neuraz Antoine
Published: April 2022

UNSTRUCTURED

Not applicable
Teledermatology in Chile: Implementation of a single national system. (Preprint)
Authors: Gatica Monsalve José Luis , Aedo Gabriel , Letelier María , Sabando Vezna , Loubies Rodrigo , Fuenzalida Hector , Aragon-Caqueo Diego , Martinez Gabriel
Published: April 2022

UNSTRUCTURED

SUMMARY:
Introduction: Teledermatology(TD) allows the delivery of timely and quality care. Although the implementation of local systems has shown to provide good levels of resolvability, the implementation of a single system at the national level allows to reach all geographical areas in a uniform and timely manner.
Objective: To describe the results of the implementation of a unified national TD system in Chile.
Methods: Observational-retrospective study of electronic interconsultations (EIs) resolved by TD specialty in national teledermatology system from December 1st, 2018, to December 31st, 2020.
Results: A total of 49,211 electronic interconsultations from all geographic areas of Chile. From these, 57.55% received a diagnosis and treatment that could be delivered in a Primary Health Care (PHC), thus, preventing the inadequate referral of 28,321 patients to the secondary level. The most frequent specific diagnoses were: melanocytic nevus 8.86% (n:4364), Non-melanoma skin cancer 8.73%(n:4294) and irritant contact dermatitis 8.2%(n:4037).From the sample, female sex accounted for 29,942(60.8%) of the consultations. Age and latency in the resolution of median EI/interquartile range were 43/24 years and 3.5/6.4 days respectively. Finally, the diagnostic agreement between the TD specialist and the PHC physician was 71.03%.
Conclusion: The implementation of a single national TD system, which incorporates a high volume of IE and all the geographical areas of Chile, has shown to have high levels of resolvability, low waiting times, and a high level of resolution centers of origin. This could be an alternative to optimize healthcare attention in the public system of low to middle-income countries.
Zhou Youguang’s View of Modern Chinese Characters and its Significance
Authors: Liu Haowen
Published: April 2022

As one of the most famous linguists in China, Zhou Youguang made a great deal of beneficial researches to form his view of modern Chinese characters and research the modern Chinese characters teaching. Under the background of the current era, Zhou Youguang’s view of modern Chinese characters is still of great significance. By thinking about his view, the future generations can gain valuable information and experience. Therefore, it is necessary for us to further study Zhou Youguang’s view of modern Chinese characters.
Mehrwert der Stipendien- und Forschungskooperationsprogramme des BMBWF
Authors:   WPZ Research GmbH, Ecker Brigitte , Pfaffel Andreas , Régent Verena
Published: April 2022

Die vorliegende Evaluierungsstudie hat das Ziel, den Mehrwert für Fördernehmerinnen und Fördernehmer der Stipendien- und Forschungskooperationsprogramme der fünf onderrichtlinien namens Auslandslektorate, Stipendienprogramme INCOMING, Stipendienprogramme OUTGOING, Programmstipendien und Maßnahmen zur Internationalisierung zur Förderung der Mobilität von Studierenden, Lehrenden und Forschenden an Hochschul- und Forschungsinstitutionen in Österreich sowie im Ausland näher zu betrachten. Der Evaluierungszeitraum umfasst die Jahre 2016–2021.
Isolation, Phenotypic Identification and Antibiotic Resistance Profile of Bacterial Isolates from Intestinal Fluids of Local Minahasa Pigs, North Sulawesi, Indonesia
Authors: Mege Revolson Alexius , Semuel Mokosuli Yermia , Manampiring Nonny , Adil Ellen Hettie
Published: April 2022

The Minahasa local pig is unique because it is the oldest local pig that has spread to the Philippine islands. Minahasa local pigs have endemic characteristics because they are in the Wallacea zone. Research has been carried out to isolate bacteria from pig intestinal fluid and obtain an antibiotic response profile from pure bacterial isolates. Pig samples were obtained from two locations in North Sulawesi, namely in North Minahasa and North Minahasa. Intestinal fluids are taken immediately when the pig is slaughtered. The liquid was preserved in a sterile container and inoculated directly on the nutrient agar medium by the dilution method. The bacterial isolates obtained were pure cultured and then used for automatic phenotypic identification using Vitek 2 Compact. The results showed that pure culture isolates were obtained from intestinal fluids of local pigs in Minahasa, North Sulawesi, indicating that two isolates (S1 and S2) were Escherichia coli and S3 was Enterobacter aerogenes. Isolate S1 showed resistance to Ampicillin, while isolate S2 showed resistance to Tetracycline, furthermore isolate S3 showed resistance to Tetracycline, Furanes, and Trimethoprim/Sulfonamide. The results confirm that further research is needed to isolate and test the antibiotic resistance of bacteria from pig intestines in several locations and various stages of common local pigs.
Diabetes Prediction Using Machine Learning
Authors: R Ashwini , Afshin S M Aiesha , V Kavya , Raj Prof. Deepthi
Published: April 2022

Abstract: The concept of machine learning has quickly become very attractive to the healthcare industry. Predictions and analyzes made by the research community on medical data sets help with appropriate care and precautions in the prevention of disease. of machine learning, the types of algorithms that can help make decisions and predictions. We also discuss various applications of machine learning in the medical field, with a focus on diabetes prediction through machine learning. Diabetes is one of the most increasing diseases in the world and it requires continuous monitoring. To check this, we explore various machine learning algorithms which will help in early prediction of this disease. This work explains various aspects of machine learning, the types of algorithm which can help in decision making and prediction. The predictions and analysis made by the research community for medical dataset support the people by taking proper care and precautions by preventing diseases. Discuss various applications of machine learning in the field of medicine focusing on the prediction of diabetes through machine learning. Diabetes is one of the fastest-growing diseases in the world and requires constant monitoring. To verify this, we are exploring different machine learning algorithms that will help with this baseline prediction. Keywords: Decision Support Systems, Diabetes, Machine learning, Support vector Machine, Random Forest, K-Nearest Neighbor, Logistics Regression
Design and Fabrication of Electric Forklift
Authors: Yadav Jayesh , Vishwakarma Manish , Shakir Siddiqui Mohd , Yadav Sanoj , Rehman Yusuf
Published: April 2022

Abstract: In today life there is wide of forklifts variety of forklifts from the large heavy loadings trucks to the one that works among narrow aisles forklifts have becomes one of basics transportation tools we use in our lives with all the forklifts in existence we find that there are some improvement that can be to bring forklifts to the better performance. We describe forklift powered by an electric motor instead of the IC engine using rechargeable batteries the main objective of this project is to design electrically powered forklift for material handling in industrial warehouses and workshops. Nowadays in industries, the forklift operates on an IC engine for transportation and hydraulic system for lifting and lowering of materials. Due to this mode of operation, there are many adverse environmental impacts such as emission of carbon dioxide and leakage of hydraulic fluid. Thus, this project aim to making the electric system into a forklift to make it electrically powered which lift to 1 ton kg and elevate up to 8 feet. Keyword: Forklift, Heavy Loads, Transportation, I.C engine, Industrial Warehouse, Environment, Electrically Powered.
LEITURAS DA VIOLÊNCIA ESCOLAR PERANTE O PROJETO CONTEMPORÂNEO DE EDUCAÇÃO DE DELORS
Authors: Carolino Lucas
Published: April 2022

Delors’ report (1988) has a worldwide proposal for schools to fulfill a missiono f adapting to four pillars: learning to know, learning to do, learning to live together and learning to be. From Delors’ report, here called the contemporary education project, it can be observed that the new current school education settings have been preparing young people and adolescents for the job market and to develop skills for coexistence, group and teamwork, to later develop these skills along with professional work activities. It is convenient to analyze this generalist proposal and its impacts in Brazil, as well as whether this report would be directly related to school violence. Therefore, this essay proposes to critically reflect on it based on psychology and two techniques (listening and working with groups) that the psychologist has for a comparative analysis of models.
В пространстве научного центра: условия труда ученых
Authors: Бочаров Юрий , Фрезинская Наталия , Сергеев Кирилл
Published: April 2022

В статье рассматриваются проблемы пространственной организации научных центров, возникших в нашей стране. Условия труда учёных исследуются на примере Пущинского научного центра биологических исследований, Новосибирского научного центра, Научно-образовательного центра на острове Русский во Владивостоке. Привлекаются материалы, отражающие развитие объектов науки в США, Чили, Германии, Великобритании, Франции и Швейцарии. Анализируются подходы к решению проектных задач и даются предложения, актуальные в сегодняшних обстоятельствах. Тексты статьи сопровождаются графиком, чертежами и фотографиями.

Выполняется анализ факторов, способных оказывать существенное воздействие на функциональный состав и планировку градостроительных образований, ставших очагамисосредоточения учёных. Отмечается необходимость расширения сети центров коллективного пользования (в том числе установок класса мегасайенс), обеспечивающих возможности продвижения фронта научных исследований при одновременной экономии земельных ресурсов и денежных средств. Характеризуются особенности взаимного размещения подразделений, ведущих дистанционные исследования. Предлагается учитывать индивидуальные требования участников производственного процесса к его материальной среде, создавать центры нестандартных заказов на территории научных зон.

Подчёркивается, что развитие информационно-коммуникационных технологий не снижает потребности в личных деловых контактах, ими обуславливается необходимость создания зон профессионального общения и временного жилища, интерактивных музеев и выставочных комплексов. Исследуется роль культурной среды и живописных природных ландшафтов в процессах творческой деятельности. Выводы и предложения авторов иллюстрируются экспериментальной схемой планировки Заречья – научного центра, размещённого на условной площадке в Подмосковье, к западу от Москвы.
Университет и город. Очерк эволюции связи университетской институции с городской средой. Часть II. Особенности формирования российских университетов, современное состояние, модель межуниверситетского кампуса
Authors: Кулешова Галина
Published: April 2022

В стране поставлена задача реализации программы стро­ительства межуниверситетских кампусов — важных ресурсов развития как образовательного комплекса, так и городской среды региональной столицы. В статье прослежена эволюция развития университетов, их влияние на города размещения, характеристики университетских кампусов за рубежом. Освещены вопросы современного состояния университетской инфраструктуры, размещение новых кампусов в составе городских территорий.
Strategic regulation and planning analysis of stratification in private colleges
Authors: Adriansyah Gusti , Ngibad Khoirul , Rodli Achmad Fathoni , Ekasari Ratna , Arif Donny
Published: April 2022

This study aims to assess the differentiation of the freedom to learn independent campus (FLIC) program level in the Indonesian Ministry of Education and Culture policies, determine objectives scope, assess internal resources, analyze regulations, develop competitive strategies, and implement and evaluate them. FLIC is a program for students who learn outside of campus in collaboration with companies and work experience converted as academic assessments. Using a quantitative design method with a sample of the university population can provide an objective evaluation of a study. The research results of stratified data reveal different values of the entire population sample at the university level with the faculty and study program levels. It was found that there was an increase in the percentage of students’ interests and talents in implementing the FLIC program from the government, and the freedom to choose lecturers outside of tertiary institutions was the most attractive factor (Hu, Liu, Chen, & Qin, 2018). Meanwhile, the main finding in this study is that there is a significant increase in the data obtained at the faculty level in the implementation of FLIC activities. Another result that supports the executive’s attitude who can provide solutions from implementing this policy is that at the lowest level, the organizational structure of universities becomes more effective in implementing the FLIC program from the government
Clinical indicators for asthma-COPD overlap: a systematic review and meta-analysis
Authors: Peng Junjie , Wang Min , Li Xiaoou , Shen Yongchun , Chen Lei , Wen Fuqiang
Published: April 2022

Background: Some clinical indicators have been reported to be
useful in differentiating asthma-COPD overlap (ACO) from pure
COPD/asthma, but the results were inconsistent. This study aims to
evaluate the diagnostic value of these indicators for ACO.
Methods: Databases of PubMed, EMBASE, Ovid and Web of Science
were retrieved. Pooled standardized mean difference (SMD) with 95%CI
was calculated in random effects model. Heterogeneity was explored
through I-squared statistic. Publication bias was assessed via
funnel-plot with begg’s and egger’s tests. Results: 46 eligible
studies were included. The pooled results indicated, compared with pure
COPD, ACO patients had higher FEV % (SMD=0.16, 95%CI
0.05 to 0.27), DLCO% (SMD=0.38, 95%CI 0.16 to 0.6), FeNO (SMD=0.58,
95%CI 0.38 to 0.78), serum total IgE (SMD=0.42, 95%CI 0.07 to 0.76),
blood eosinophil (SMD=0.43, 95%CI 0.26 to 0.61), percentage of induced
sputum eosinophil (SMD=0.62, 95%CI 0.42 to 0.83), and lower percentage
of induced sputum neutrophil (SMD=-0.48, 95%CI -0.7 to -0.27),
circulating YKL-40 (SMD=-1.09, 95%CI -1.92 to -0.26). However, compared
with asthma alone, ACO patients had lower FEV %
(SMD=-1.1, 95%CI -1.32 to -0.87), DLCO% (SMD=-0.83, 95%CI -1.24 to
-0.42), FeNO (SMD=-0.25, 95%CI -0.38 to -0.11), and higher percentage
of induced sputum neutrophil (SMD=0.51, 95%CI 0.21 to 0.81),
circulating YKL-40 (SMD=0.96, 95%CI 0.27 to 1.64).
Conclusions: Compared with pure COPD/asthma, ACO patients have
different levels of FEV %, DLCO%, FeNO, serum total
IgE, blood eosinophil, percentage of induced sputum
eosinophil/neutrophil, and circulating YKL-40, which could be helpful to
establish a clinical diagnosis of ACO. More studies are warranted to
validate these findings.
House mouse subspecies do differ in their social structure
Authors: Mikula Ondřej , Macholán Miloš , Ďureje Ľudovít , Hiadlovská Zuzana , Daniszová Kristina , Janotová Kateřina , Bímová Barbora Vošlajerová
Published: April 2022

It is widely acknowledged that population structure can have a
substantial impact on evolutionary trajectories. In social animals, this
structure is strongly influenced by relationships among the population
members, so studies of differences in social structure between diverging
populations or nascent species are of prime interest. Ideal models for
such a study are two house mouse subspecies, Mus musculus
musculus and M. m. domesticus, meeting in Europe along a
secondary contact zone. Though the latter subspecies has usually been
supposed to form tighter and more isolated social units than the former,
the evidence is still inconclusive. Here, we carried out a series of
radio-frequency identification experiments in semi-natural enclosures to
gather large longitudinal datasets on individual mouse movements. The
data were summarised in the form of uni- and multi-layer social
networks. Within them, we could delimit and describe the social units
(‘modules’). While the number of estimated units was similar in both
subspecies, domesticus revealed a more ‘modular’ structure. This
subspecies also showed more intramodular social interactions, higher
spatial module separation, higher intramodular persistence of
parent-offspring contacts, and lower multiple paternity, suggesting more
effective control of dominant males over reproduction. We also
demonstrate that long-lasting modules can be identified with basic
reproductive units or demes. We thus provide the first robust evidence
that the two subspecies differ in their social structure and dynamics of
the structure formation.
Possibilistic uncertainty assessment in the presence of optimally integrated solar PV-DG and probabilistic load model in distribution network
Authors: Parihar Shradha , Malik Nitin
Published: April 2022

To integrate network load and line uncertainties in the radial distribution
network (RDN), the probabilistic and possibilistic method has been applied.
The load uncertainty is considered to vary as Gaussian distribution function
whereas line uncertainty is varied at a fixed proportion. A voltage
stability index is proposed to assign solar PV-DG optimally followed by
application of PSO technique to determine the optimal power rating of DG.
Standard IEEE 33- and 69-bus RDN are considered for the analysis. The impact
of various uncertainties in the presence of optimally integrated solar PV-DG
has been carried out on 69-bus network. The results obtained are superior to
fuzzy-arithmetic algorithm. Faster convergence characteristic is obtained
and analyzed at different degree of belongingness and realistic load models.
The narrower interval width indicates that the observed results are
numerically stable. To improve network performance, the technique takes into
account long-term changes in the load profile during the planning stage. The
significant drop in network power losses, upgraded bus voltage profile and
noteworthy energy loss savings are observed due to the introduction of
renewable DG. The results are also statistically verified.
Dignity of Human Life in Bioethics
Authors: Kusmaryant Carolus Boromeus
Published: April 2022

Dignity of human life is widely uses in bioethics. There are many controversial topics in bioethics which uses human dignity as the basis of their argument. UNESCO’s Universal Declaration of Bioethics and Human Rights placed human dignity, human rights and fundamental freedom as the basic principle of bioethics. Human dignity become a solid and strong foundation for bioethical principles, in which, human being is placed at the center of the development of science and technology and not marginalized.
Penggunaaan Teknologi Dalam Pembelajaran Daring Pada Kelompok Kerja Guru PAI SD
Authors: Rusdiani Atik , Saputra Joni
Published: April 2022

Tujuan dari pengabdian masyarakat ini adalah untuk membantu guru PAI pada Kelompok Kerja Guru PAI SD Kecamatan Natar dengan memberikan dukungan/pelatihan/bimbingan penggunaan teknologi dalam pembelajaran daring sehingga pembelajaran daring dapat dilakukan dengan baik di SD kecamatan Natar. Metode implementasi melalui mentoring, pelatihan dan lokakarya.. Haasil pretest menunjukkan 16% peserta kurang memahami teknologi, dan 84% peserta tidak memahami teknologi. Hasil post- tes menunjukkan 36% peserta baik memahmi teknologi dan  64% peserta cukup baik memahami teknologi. Kegiatan ini berlangsung dengan berlatih menggunakan teknologi dalam pembelajaran online untuk meningkatkan pemahaman dan sumber daya guru PAI dalam penggunaan teknologi yang efektif dan maksimal dalam pembelajaran daring
Kesetaraan Gender dan Pendidikan Humanis
Authors: Fitriani Erda , Neviyarni Neviyarni
Published: April 2022

Gender equality is still a target for countries that are members of the SDGs, including Indonesia. Efforts to improve gender equality are mainly through education, both family education and school education. Gender responsive education has been carried out in Indonesia and has become a target for sustainable development with the SDGs program, which is targeted to be achieved by 2030. Various phenomena of gender inequality are still encountered in society. This shows that there are problems in the perception and application of gender equality. One of the efforts to give birth to justice and gender equality is through education. Therefore, this article aims to explain the concept of gender and gender equality and then gender equality education.
Peran Ganda Ibu Dalam Pendidikan Anak di Saat Pandemi Covid-19
Authors: Khairat Nadya Nurul , Junaidi Junaidi
Published: April 2022

During the Covid-19 Pandemic, all learning activities are carried out online, all aspects of life become unstable, having implications for all aspects of human life, including the community's economy. Many heads of households have lost their jobs, and there are some heads of households who are unable to meet the needs of their families. Basically a housewife has duties in the family such as: serving her husband, raising children, cooking, cleaning the house and other general activities that are carried out like a housewife. But in reality many women, especially housewives, work to help their husbands to support their families. The theory used isThe role theory (role theory) was put forward by Stephen & Stephan. The research method used is qualitative with the type of case study. In this study, researchers selected informants by purposive sampling. The data analysis technique used is data analysis technique from Milles and Hurberman through analysis consisting of three activity lines, (1) reduction, (2) data presentation, and (3) conclusion drawing/verification.
Mewujudkan Perajin Gerabah yang Mandiri Melalui Program
Authors: Rubiyatno Rubiyatno , Wuri Josephine , Apriani Lisia
Published: April 2022

The purpose of this community service is to enhance entrepreneurial motivation, improve understanding of human resource optimization, improve partners' understanding of business plans and also produce business plan documents as business development plans and improve financial management. As a result, innovative product designs have the value of selling by utilizing information technology, understanding and entrepreneurship skills in their fields, enhancing the ability of craftsmen in using the Internet network for expansion of marketing, improving financial management through cash flow, and the ability of partners to operate a financial-based application program a simple computer. Participatory approaches are used for partners to actively participate in all activities from start to finish. After conducting discussion with Partners 1 and 2, we provided the necessary training and mentoring to help overcome the weaknesses of Partners 1 and Partners 2, pottery craftsmen in Panjangrejo Pundong area, Bantul. After completing the program, it can be concluded that Partner 1 and Partner 2 were extremely enthusiastic in this activity due to the desire to be good at developing their business and all targeted indicators have been achieved, for example, customer identification and availability of production equipment.
LOKAKARYA KEPALA SEKOLAH DAN STAF SMK ASJI TENTANG PPI
Authors: Suparno Paul
Published: April 2022

The purpose of this workshop was to help ASJIs SMK principals and curriculum staff better understand the Ignatian Pedagogical Paradigm (Paradigma Pedagogi Ignatian -- PPI). The SMK principals and staff were aware that they did not understand enough what PPI was and how to apply PPI in the context of Vocational High Schools (Sekolah Menengah Kejuruan -- SMK). So they wanted to know better and learned more about the PPI spirit, values, and dynamics.To help those principals and staffs needs, ASJI provided a workshop on PPI. A lecturer from Sanata Dharma University was invited to guide the workshop as an instructor. During the workshop, the participants discussed PPI and planned how to apply and improve PPI in their own schools. The result was that every school made one program (RPP) to implement PPI in their schools.