bluuebunny/crossref_metadata_2025 huggingface dataset:
Higher Risk of Tumor Recurrence in NASH-Related Hepatocellular Carcinoma Following Curative Resection
Authors: Chien Shih-Chieh , Lin Yih-Jyh , Lee Chun-Te , Chiu Yen-Cheng , Chou Tsung-Ching , Chiu Hung-Chih , Tsai Hung-Wen , Su Che-Min , Yang Tsung-Han , Chiang Hsueh-Chien , Tsai Wei-Chu , Yang Kai-Chun , Cheng Pin-Nan
Published: November 2022

Background: The outcomes for patients with NASH-related HCC after curative resection have not been clarified. This study compared the overall survival (OS), time-to-tumor recurrence (TTR), and recurrence-free survival (RFS) associated with NASH-related HCC and virus-related HCC after resection. Methods: Patients with HCC who underwent curative resection were retrospectively enrolled. Baseline characteristics, including disease etiologies and clinical and tumor features, were reviewed. The primary outcomes were OS, TTR, and RFS. Results: Two hundred and six patients were enrolled (HBV: n = 121, HCV: n = 54, NASH: n = 31). Of those with virus-related HCC, 84.0% achieved viral suppression. In both the overall and propensity-score-matched cohorts, those with NASH-related HCC experienced recurrence significantly earlier than those with virus-related HCC (median TTR: 1108 days vs. non-reached; p = 0.03). Through multivariate analysis, NASH-related HCC (hazard ratio (HR), 2.27; 95% confidence interval (CI), 1.25–4.12) was independently associated with early recurrence. The unadjusted RFS rate of the NASH-related HCC group was lower than the virus-related HCC group. There was no difference in the OS between the two groups. Conclusions: NASH-related HCC was associated with earlier tumor recurrence following curative resection compared to virus-related HCC. Post-surgical surveillance is crucial for detecting early recurrence in patients with NASH-related HCC.
IL-33 Induces an Antiviral Signature in Mast Cells but Enhances Their Permissiveness for Human Rhinovirus Infection
Authors: Akoto Charlene , Willis Anna , Banas Chiara , Bell Joseph , Bryant Dean , Blume Cornelia , Davies Donna , Swindle Emily
Published: November 2022

Mast cells (MCs) are classically associated with allergic asthma but their role in antiviral immunity is unclear. Human rhinoviruses (HRVs) are a major cause of asthma exacerbations and can infect and replicate within MCs. The primary site of HRV infection is the airway epithelium and MCs localise to this site with increasing asthma severity. The asthma susceptibility gene, IL-33, encodes an epithelial-derived cytokine released following HRV infection but its impact on MC antiviral responses has yet to be determined. In this study we investigated the global response of LAD2 MCs to IL-33 stimulation using RNA sequencing and identified genes involved in antiviral immunity. In spite of this, IL-33 treatment increased permissiveness of MCs to HRV16 infection which, from the RNA-Seq data, we attributed to upregulation of ICAM1. Flow cytometric analysis confirmed an IL-33-dependent increase in ICAM1 surface expression as well as LDLR, the receptors used by major and minor group HRVs for cellular entry. Neutralisation of ICAM1 reduced the IL-33-dependent enhancement in HRV16 replication and release in both LAD2 MCs and cord blood derived MCs. These findings demonstrate that although IL-33 induces an antiviral signature in MCs, it also upregulates the receptors for HRV entry to enhance infection. This highlights the potential for a gene-environment interaction involving IL33 and HRV in MCs to contribute to virus-induced asthma exacerbations.
The Application of Passive Sampling Devices in Wastewater Surveillance
Authors: Shakallis Andreana G. , Fallowfield Howard , Ross Kirstin E. , Whiley Harriet
Published: November 2022

Wastewater-based epidemiology (WBE) is a surveillance approach used to examine chemical and biological targets within a population. Historically, the most common approaches to wastewater sampling include grab sampling and composite sampling, which can be performed manually or using an automated sampler. However, there are inherent flaws with these sampling methods. They can miss analytes due to fluctuation events in wastewater and can have high cost and labour implications. Alternately, passive sampling is a technique that involves a sampling medium that can stay in an aqueous matrix for extended periods of time to provide a greater temporal coverage. This literature review examines the current passive sampling devices used in wastewater surveillance and the general contaminants they are targeting. The polar organic chemical integrated sampler, Chemcatcher®, diffusive gradients in thin films sampler and semipermeable membrane devices were among the most frequently deployed samplers in wastewater matrices. Chemical contaminants and pharmaceuticals were identified as the most common targets. Passive sampling of biological targets has received recent attention due to the surveillance of SARS-CoV-2; however, overall, there is a lack of critical knowledge relating to the deployment and associated variability of passive samplers used for biological targets. Notwithstanding, the ability of passive sampling to capture temporal fluctuation of analytes in wastewater make it a useful sampling technique for the surveillance of pathogens in the community. Future research should focus on addressing the gaps in knowledge to optimise the use of these sampling devices.
Morphological Adjustment and Diversion Discharge Prediction in the Three Outlets Channel of the Jingjiang River
Authors: Chen Bang , Li Zhiwei , Hu Xuyue , Wang Danyang
Published: November 2022

The Three Outlets Channel (TOC) consisting of three anabranching rivers formed due to natural avulsion by extremely high floods, is the primary water–sediment channel connecting the Jingjiang in the middle Yangtze River and Dongting Lake (the second largest freshwater lake in China). Since the impoundment of the Three Gorges Reservoir (TGR) in 2003, the decreasing diversion of runoff and sediment load of the TOC has an impact on the hydrological connectivity of the river–lake relation. Nonetheless, it lacks complete understanding on the diversion of runoff and sediment load, erosion and deposition amount, and the calculation method of diversion runoff in the TOC. We used remote sensing images, hydrological data, and channel topography to analyze the change in runoff and sediment load, channel morphology, local erosion and deposition amounts. The main results show that: (i) Meander cutoffs of the Lower Jingjiang accelerated the reduction process of the Ouchi River’s runoff and sediment load and the increase in the number of dry days. After the impoundment of the TGR, the diversion of sediment load of the TOC was greatly affected, but the decreasing trend of the runoff diversion slowed down. (ii) The morphological change of the inlet zone of Ouchi River is larger than that of Songzi River and Hudu River. The morphological evolution of the inlet area led to the change in the diversion of runoff and sediment load of the TOC. (iii) In the dry season, the water level drop in the inlet zone of the TOC leads to a decrease in the diversion discharge. Therefore, considering the water level drop and channel width adjustment in the inlet zone, five empirical formulae for the diversion discharge of the five hydrological stations in the TOC are proposed. These empirical formulae can be used as a short-term forecast for future changes in the hydrologic regime and the dynamics of the Jingjiang–Dongting Lake relation.
Identification of Suitable Sites Using GIS for Rainwater Harvesting Structures to Meet Irrigation Demand
Authors: Preeti Preeti , Shendryk Yuri , Rahman Ataur
Published: November 2022

This study uses a multi-criteria decision analysis approach based on geographic information system (GIS) to identify suitable sites for rainwater harvesting (RWH) structures (such as farm dam, check dam and contour bund) to meet irrigation demand in Greater Western Sydney region, New South Wales, Australia. Data on satellite image, soil, climate, and digital elevation model (DEM) were stored in GIS layers and merged to create a ranking system, which were then used to identify suitable RWH (rainwater harvesting) areas. The resulting thematic layers (such as rainfall, land use/land cover, soil type, slope, runoff depth, drainage density, stream order and distance from road) were combined into one overlay to produce map of RWH suitability. The results showed that 9% of the study region is ‘very highly suitable’ and 25% is ‘highly suitable’. On the other hand, 36% of the area, distributed in the north-west, west and south-west of the study region, is ‘moderately suitable’. While 21% of the region, distributed in east and south-east part of the region, has ‘low suitability’ and 9% is found as ‘unsuitable area’. The findings of this research will contribute towards wider adoption of RWH in Greater Western Sydney region to meet irrigation demand. The developed methodology can be adapted to any other region/country.
Application of Empirical Approaches for Fast Landslide Hazard Management: The Case Study of Theilly (Italy)
Authors: Segoni Samuele , Barbadori Francesco , Gatto Alessio , Casagli Nicola
Published: November 2022

Landslide hazard management usually requires time-consuming campaigns of data acquisition, elaboration, and modeling. However, in the post-emergency phase management, time is a factor, and simpler but faster methods of analysis are needed to support decisions even in the short-term. This paper analyzes the Theilly landslide (Western Italian Alps), which was recently affected by a series of reactivations. While some instrumental campaigns are being carried out to support the design of protection measures, simple tools are also needed to assess the hazard of future reactivations and to evaluate the possibility of damming the torrent at the footslope. Therefore, state-of-the-art empirical methods were used and customized for the specific case study: a set of intensity–duration rainfall thresholds depicting increasing hazard levels was defined to monitor and forecast possible reactivations, while a methodology based on hydro-morphometric indices was applied to the case of study, to assess the possible evolution scenarios (landslide that does not dam the river, formation of a stable dam, formation of an unstable dam), based on the landslide volume. The proposed empirical methodologies have the advantage of requiring only ready-available input data and quick elaborations, thus allowing the rapid set up of tools that could be used for hazard management.
Atmospheric Water Harvesting with Metal-Organic Frameworks and Their Composites: From Materials to Devices
Authors: Huang Xiuying , Qin Qin , Ma Qinglang , Wang Bo
Published: November 2022

Clean water scarcity is deteriorating because of the growing population and water pollution. New methods to harvest freshwater from non-traditional water sources are urgently required to address this global issue. The atmosphere contains abundant water resources. Harvesting fresh water from the air has become an emerging and attractive approach, among which sorption-based atmospheric water harvesting (AWH) is the most promising method, as it demonstrates high water producibility, wide applicability and low energy consumption. Metal-organic frameworks (MOF) are a class of emerging porous materials characterized by their large specific surface area, adjustable pore structures and chemistry. Recently, hydrolytically stable MOFs have been used as sorbents in AWH, and several MOF-based prototyping devices have been demonstrated with great practical potential. In this review, we briefly summarize the recent progress on the MOFs and their derived composites as AWH sorbents. Then, we introduce several most representative devices using MOFs for practical applications. Finally, the challenges and perspectives of this emerging field are discussed.
Stormwater Management in Urban and Rural Areas
Authors: Kazak Jan K. , Dąbrowska Jolanta , Bednarek Agnieszka
Published: November 2022

In past decades, traditional stormwater management in urban and rural areas was associated with a rapid transfer of water to sewage systems or ditches, which resulted in pollutants and large volumes of water being carried to rivers and streams [...]
A Novel CYP4 Gene Identified in the Polychaete Sternaspis scutata and Its Transcriptional Levels along the Coasts of the Liaodong Peninsula
Authors: Yu Zhenglin , Qi Aimin , Wang Lili , Shan Encui , Li Dongmei , Yang Xiaolong , Zhang Anguo
Published: November 2022

Polychaetes (such as Sternaspis sculata) can biotransform polycyclic aromatic hydrocarbons (PAHs) in the environment, and the cytochrome P450 (CYP) enzyme is the key substance in this process. Here, a novel CYP gene was identified from S. sculata, a marine polychaete that is abundantly distributed along marine coasts worldwide. The full-length cDNA of the new CYP is a 1829 bp, encoding a protein of 509 amino acids. The deduced amino acid sequence of the CYP gene contains the conserved motifs of the P450 family (FxxGxxxCxG) and the characteristic sequences of the CYP4 family (EVDTFMFEGHDTT), showing high similarity to CYP4V from marine polychaetes. Therefore, the cDNA sequence might belong to the subfamily of CYP4V, tentatively named SsCYP4V. The expression levels of SsCYP4V in the field were detected in S. sculata sampled from six sites along the coasts of the Liaodong Peninsula. The results showed that the relative expression levels of SsCYP4V in S. sculata were significantly different among the sampling sites; however, no positive relationship was found between SsCYP4V expression levels and PAHs concentrations in the sediments. These findings suggested a complexity of CYP gene expression in the field, and SsCYP4V cannot be used as a biomarker for the field monitoring of PAH pollution.
Water Resource Management through the Lens of Planetary Health Approach
Authors: Kumar Pankaj , Avtar Ram
Published: November 2022

For eternity, water resources have proven to be the key to inclusive social development and human well-being [...]
Uphill Flow Rock Ramps. How the Design Impacts Their Functionality
Authors: Carrero-Díez Leticia , Martínez Santa-María Carolina , Fernández-Yuste J. Anastasio
Published: November 2022

Enhancing river passability is considered a central part of the efforts to maintain fish population and achieving good ecological status, according to the EU Water Framework Directive (WFD). One commonly proposed approach to achieving this aim involves the creation of fishways. However, recent studies have shown that many of these fish passes are often lacking an optimal design with far reaching consequences for fish migration. Several promising new designs such as nature-like rock ramps, with uphill flow, have been recently developed. Such studies attempt to address these drawbacks by adapting several structure-related features (i.e., boulder size and shape and friction walls). In this study, we used a 2D computational fluid dynamic model to assess how the key hydraulic variables (water depth, velocity and turbulent kinetic energy) were impacted by different design elements of uphill flow fishways with different configurations. With regard to the standard boulder shapes and sizes, our results reveal that: (1) doubling the boulder sizes results in a decrease of turbulent kinetic energy in resting corridors of up to 33%; (2) the inclusion of small friction-walls in the ramp design increases uphill velocity in the intermediate corridors by up to 49%; (3) the trapezoidal shape of the boulder leads to the largest decreases in maximum velocity in the gaps (16%) and the largest increases in the uphill velocity in the resting corridors (180%). These results may allow us to optimise the uphill flow rock-ramp design to improve the passability of this type of fishways.
A Continuous Multisite Multivariate Generator for Daily Temperature Conditioned by Precipitation Occurrence
Authors: Hernández-Bedolla Joel , Solera Abel , Paredes-Arquiola Javier , Sanchez-Quispe Sonia Tatiana , Domínguez-Sánchez Constantino
Published: November 2022

Temperature is one of the most influential weather variables necessary for numerous studies, such as climate change, integrated water resources management, and water scarcity, among others. The temperature and precipitation are relevant in river basins because they may be particularly affected by modifications in the variability, for example, due to climate change. We developed a stochastic model for daily precipitation occurrences and their influence on maximum and minimum temperatures with a straightforward approach. The Markov model has been used to determine everyday occurrences of rainfall. Moreover, we developed a multisite multivariate autoregressive model to represent the short-term memory of daily temperature, called MASCV. The reduction of parameters is an essential factor addressed in this approach. For this reason, the normalization of the temperatures was performed through different nonparametric transformations. The case study is the Jucar River Basin in Spain. The multisite multivariate stochastic model of two states and a lag-one accurately represents both occurrences as well as maximum and minimum temperature. The simulation and generation of occurrences and temperature is considered a continuous multivariate stochastic process. Additionally, time series of multiple correlated climate variables are completed. Therefore, we simplify the complexity and reduce the computational time for the simulation.
Two-Phase Annular Flow in Vertical Pipes: A Critical Review of Current Research Techniques and Progress
Authors: Xue Yunpeng , Stewart Colin , Kelly David , Campbell David , Gormley Michael
Published: November 2022

Two-phase annular flow in vertical pipes is one of the most common and important flow regimes in fluid mechanics, particularly in the field of building drainage systems where discharges to the vertical pipe are random and the flow is unsteady. With the development of experimental techniques and analytical methods, the understanding of the fundamental mechanism of the annular two-phase flow has been significantly advanced, such as liquid film development, evolution of the disturbance wave, and droplet entrainment mechanism. Despite the hundreds of papers published so far, the mechanism of annular flow remains incompletely understood. Therefore, this paper summarizes the research on two-phase annular flow in vertical pipes mainly in the last two decades. The review is mainly divided into two parts, i.e., the investigation methodologies and the advancement of knowledge. Different experimental techniques and numerical simulations are compared to highlight their advantages and challenges. Advanced underpinning physics of the mechanism is summarized in several groups including the wavy liquid film, droplet behaviour, entrainment and void fraction. Challenges and recommendations are summarized based on the literature cited in this review.
Evaluation of the Impact of Drought and Saline Water Intrusion on Rice Yields in the Mekong Delta, Vietnam
Authors: Minh Huynh Vuong Thu , Lavane Kim , Ty Tran Van , Downes Nigel K. , Hong Tran Thi Kim , Kumar Pankaj
Published: November 2022

The Mekong delta is Vietnam’s premier rice growing region, forming the livelihood basis for millions of farmers. At the same time, the region is facing various challenges, ranging from extreme weather events, saline water intrusion, and other anthropogenic pressures. This study examines how saline water intrusion and drought have affected rice yield in the Vietnamese Mekong Delta (VMD). Applying the Standardized Precipitation Index (SPI) and the maximum and minimum values of annual average salinity, we spatially examine the effects of drought and saline water intrusion on rice yields over a 40-year period (1980–2019). Our results highlight that 42% of the natural land area of the VMD has experienced increased drought occurrence during the winter-spring (WS) rice cropping season, while certain inland regions have additionally experienced increased drought occurrence during the summer-autumn (SA) rice cropping season. The Tri Ton Station, which has a significant Sen’s slope of −0.025 and a p-value of 0.05, represents an upstream semi-mountainous part of the delta, indicative of a rising severity of reoccurring drought. It should be noted that the yield decreases during the summer-autumn season as the positive SPI_SA increases. Salinity, on the other hand, is associated with SPI_WS during the winter-spring season. Our results highlight the need for improved evidence-based planning and investments in priority adaptation for both sustainable water infrastructure and to improve system resilience.
Operasi Tunneling Dengan Metode Natm Pada Pembangunan Terowongan Walini Kereta Api Cepat Jakarta-Bandung
Authors: Tanne Yongki Alexander
Published: November 2022

Dalam pelaksanaan Proyek Kereta Api Cepat Jakarta-Bandung diperlukan perencanaan dan analisa operasi konstruksi untuk mendapatkan metoda terbaik dan tingkat produktivitas tinggi. Pada tahap operasi diperlukan pengendalian agar memperoleh hasil yang efektif dan efisien. Penelitian ini melakukan pemodelan dan simulasi untuk operasi tunneling sepanjang 608 meter menggunakan metode NATM pada pekerjaan Terowongan Walini KCIC berdasarkan data-data eksisting resource dan durasi pekerjaan yang diperoleh. Pekerjaan Terowongan Walini merupakan salah satu pekerjaan yang mempunyai resiko tinggi terjadinya kegagalan sehingga dilakukan simulasi model operasi tunneling untuk memberikan gambaran terhadap produktivitas dan durasi pekerjaan. Simulasi yang dilakukan dengan aplikasi WebCyclone dan COST menghasilkan produktivitas sebesar 1.09 m/hari dan 1.16 m/hari, nilai produktivitas yang diperoleh dari simulasi mendekati nilai rata-rata produktivitas di lapangan yang sebesar 1,20 m/hari. Dengan produktivitas hasil simulasi diperkirakan operasi tunneling dapat diselesaikan dalam waktu 524 hari. Analisis sensitivitas yang dilakukan menunjukkan bahwa jumlah resource yang digunakan saat ini belum optimal dan dapat dikurangi namun tidak memengaruhi produktivitas.
Microbial pattern and antibiotic resistance in Ardabil city hospitals
Authors: Ahvar Negar , Pourrashid Mohammad Hassan , Mohammadshahi Jafar , Bahadoram Mohammad , Amani Firouz
Published: November 2022

Introduction: Antibiotic arbitrary use by increasing resistance changed to a growing issue in the 21st century and its optimal use in hospital could be essential for reducing health system costs and drug side effects. Objectives: The aim of this study was to investigate the pattern of antibiotic use in prescribed prescription. Patients and Methods: This was a cross-sectional study that has been done on 300 prescriptions which selected randomly form Ardabil city hospitals. The anatomical therapeutic chemical classification system with defined daily doses (ATC/DDD) standard measurement method recommended by World Health Organization (WHO) was conducted in the study. The amount uses rate of each medication calculated by DDD/100 bed days. Data collected by a checklist and analyzed by statistical methods in SPSS version 21. Results: The highest prescribed antibiotic was ciprofloxacin with 32% and the total antibiotics uses rate during study period was 44/95 DDD/100 Bed days. The mean number of drugs and prescribed antibiotics in intensive care unit (ICU) ward was more than other wards. However, comparing the rate of antibiotics use between wards based on ATC/DDD method showed that the infection ward with 62.9 was more than other wards. The most form of used antibiotics with 69% was in the form of Ampule and in intravenously method with 64% in all wards. Conclusion: The results of this study showed that the most used antibiotics by considering the studied method, prescribed dose and the hospitalized days were in internal and surgery ward respectively but according ATC/DDD method the most used antibiotics was in infection ward.
The association between COVID-19 and gestational diabetes mellitus: A narrative review
Authors: Hassanzadeh Rad Afagh , Fakhre Yaseri Amirhossein
Published: November 2022

The outbreak of COVID -19 has become an important health concern with diverse complications. Based on previous studies, women with gestational diabetes mellitus (GDM) are at a higher risk of COVID -19. Although numerous investigations have assessed the epidemiological and clinical aspects of this virus in pregnancy, few articles have clearly emphasized the role of COVID-19 in increasing the risk of GDM. In this narrative review, we aimed to assess the relationship between COVID-19 and GDM.
ACE I/D polymorphism is not a genetic modifier of renal features in sickle cell anemia patients
Authors: Bhaskar LVKS , Pattnaik Smaranika
Published: November 2022

Introduction: Sickle cell anemia (SCA) exhibits a host of complications that contribute to increased morbidity and mortality at the youngest ages. Objectives: The aim of this investigation is to look into the association between ACE I/D polymorphism and renal function in Indian patients with SCA. Patients and Methods: About 190 SCA patients confirmed by hemoglobin (Hb) electrophoresis were selected for this study. The severity of the disease was determined using anemia, clinical complications, total white blood cells count, and scores of blood transfusion. To define different renal function phases, estimated glomerular filtration rate (eGFR) was computed in adults and children using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) and Schwartz equations respectively. The ACE I/D polymorphism was conducted using polymerase chain reaction (PCR) and separation through agarose electrophoresis. Results: The risk of impaired renal function was not statistically distinct between ACE I/D genotypes and alleles. Further, the genotypes of ACE I/D and the risk of disease severity was not found to be associated with each other. Conclusion: This investigation found that ACE I/D is an insignificant genetic modifier of renal function or severity of disease in patients with SCA.
Does adding ketamine to morphine in a patient-controlled intravenous analgesia pump after orthopedic surgeries help better management of postoperative pain in obese patients? A double-blinded clinical trial
Authors: Moradi Amin , Abedini Naghi
Published: November 2022

Introduction: Low doses of ketamine can cause an antagonistic effect on NMDA-receptors by blocking the magnesium-gated channels. Several studies demonstrated the effect of ketamine in improving the analgesia using opioids, however, obese people reported different reactions to this problem. Objectives: This study seeks to answer the following question: Does adding ketamine to morphine in a patient-controlled intravenous analgesia pump (PCIA) after orthopedic surgeries help better management of postoperative pain in obese patients? Patient and Methods: This double-blinded clinical trial involved 60 obese (body mass of higher than 30 kg/m²) lower limb orthopedic surgery candidates at Shohada hospital (Tabriz, Iran). The participants were randomly categorized into three groups. In group M, 20 mg morphine sulfate, in group MK1 100 mg ketamine + 20 mg morphine sulfate, and in group MK2 200 mg ketamine+10 mg morphine sulfate was added to the analgesia pump. Pain intensity (VAS), sedation score (Ramsay Scale), as well as nausea and vomiting (N&V score) were compared among different groups at 12, 24, 36, and 48 hours after the operation. Results: Group M manifested a significantly higher pain intensity than two other groups during all examined times, and group MK2 demonstrated a significantly lower pain intensity than other groups. In the course of the research, the amount of opioid consumption in group MK2 was significantly lower than in the other groups. Conclusion: The addition of a low dose of ketamine to morphine in the PCIA pump after orthopedic surgeries in obese patients results in proper postoperative pain management. Trial Registration: The trial protocol was approved in the Iranian registry of clinical trial (identifier: IRCT2017101636822N1, https://www. irct.ir/trial/27429, ethical code; IR.TBZMED.REC.1400.820).
Evaluation of the severity of COVID-19 in people living with HIV; a review study
Authors: Hosseinpour Sadeq , Mohammadi Abgarmi Zahra , Deldar Zeinab , Motahhar Minoo , Shahani Toran , Mousavi Masoumeh Sadat
Published: November 2022

Background: Patients with HIV infection may be at an increased risk for morbidity and mortality from the COVID-19. This study aimed to investigate the severity of COVID-19 disease in people living with HIV (PLHIV). Methods: We conducted a systematic review of all articles and reports conducted in the Scholar, PubMed, and Magiran databases regarding the effects of COVID-19 on PLHIV from the beginning of 2020 until today. Results: A total of 1893 articles were found. After deleting unrelated articles according to keywords, a total of 507 articles were selected, after deleting duplicate articles, 400 subjects were selected and finally, after reading the abstracts 59 studies were included in our analysis. Finally, 15 papers were selected depending on the type of review. Conclusion: The results of the present, prevalence, severity of COVID-19 in PLWH was similar general population and this finding suggests that HIV infection not a risk factor for COVID-19 , and generally, PLWH should receive the same treatment approach applied to the general population.
COVID-19 in systemic lupus erythematosus; a mini-review on current knowledge
Authors: Rafieian Mahsa , Nasri Hamid , Rabiei Yassamin
Published: November 2022

The consequences of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection vary among persons, while some individuals are at high risk. Patients with systemic lupus erythematosus (SLE) and COVID-19 necessitate particular attention. SLE cases may be at particular risk for SARS-CoV-2 due to their dysregulated immune system and immunosuppressive treatments. Organ injury and administration of systemic glucocorticoids and other immunosuppressive agents are the risk factors for severe SARS-CoV-2. Additionally, SLE is not uncommon and could be severe in some ethnicities like African and Hispanic individuals and may be accompanied by poor outcomes of SARS-CoV-2. Thus, knowledge of the triggering immune response and therapeutic modalities in SLE and SARS-CoV-2 is necessary to guide treatment of this serious infectious disease in the background of SLE and vice versa.
Certain Identities of a General Class of Hurwitz-Lerch Zeta Function of Two Variables
Authors: Pathan M. A. , Kumar Hemant , Sharma Roshni
Published: November 2022

In this paper, we introduce a generalized double Hurwitz-Lerch Zeta function and then systematically investigate its properties and various integral representations. Further, we show that these results provide certain known as well as new extensions of earlier stated results of generalized Hurwitz-Lerch Zeta functions.
Characterization of high fluoride resistant Pseudomonas aeruginosa species isolated from water samples
Authors: Edward Raja Chellaiah , Pandeeswari Ravi , Ramesh U
Published: November 2022

Groundwater fluoride contamination is one of the most serious toxicological environmental issues in India and around the world. Water samples were taken from Natham taluk and screened for fluoride resistant bacteria. Initially, twenty-four fluoride resistant colonies were selected from 50 mM NaF supplemented LB agar plates. On blood agar plates, all isolates showed β-haemolysis, confirming their status as pathogens. Virulence factors (algD, plcH, toxA, gyrB, rhlC, lasB) and biofilm-forming genes (ppyR, pelA, pslA) were identified in these isolates by PCR analysis. The fluoride ion transporter ‘crcB’ was successfully amplified from these isolates by gene-specific PCR. Genus Pseudomonas and P. aeruginosa species-specific PCR analysis identified that all strains as belonging to the P. aeruginosa species. Besides, three high fluoride resistance strains were selected based on high fluoride resistance and confirmed as P. aeruginosa species by 16S rRNA sequencing and NCBI blast analysis.
PENGARUH PENDAPATAN ASLI DESA DANA DESA DAN ALOKASI DANA DESA TERHADAP BELANJA DESA
Authors: Taen Raa’ina Syahdzat , Eriswanto Elan
Published: November 2022

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pendapatan asli desa dari dana desa dan alokasi dana desa terhadap belanja desa. Metode penelitian ini adalah metode kuantitatif. Populasi penelitian ini adalah laporan keuangan 9 desa di kecamatan Palabuhanratu i 2017-2021. Sampel dalam penelitian ini berjumlah 45. Pengambilan sampel penelitian ini menggunakan Analisis Regresi Linier Berganda dan diolah menggunakan software SPSS. Berdasarkan hasil analisis SPSS dapat diketahui bahwa pendapatan asli desa tidak berpengaruh signifikan terhadap belanja desa. Namun dana desa dan alokasi dana desa berpengaruh signifikan terhadap belanja desa di desa-desa di kecamatan Palabuhanratu.
PENERAPAN PEDOMAN AKUNTANSI PESANTREN DI PONDOK PESANTREN AL I’TISHOM KUBU RAYA
Authors: Ruci Dewa , Prasetyo Henri
Published: November 2022

Pondok pesantren merupakan salah satu lembaga pendidikan yang mengkhususkan untuk memperdalam pengetahuan di bidang keagamaan. Mayoritas Pondok pesantren dalam operasional pendidikanya mengharuskan santri menginap di lingkungan ponpes. Oleh sebab itu, diharapkan kepada pengelola untuk menyediakan fasilitas sarana dan prasana yang nyaman untuk mendukung kegiatan belajar mengajar. Dalam memfasilitasi sarana dan prasarana tersebut, ponpes membuka diri untuk menerima donasi dari kaum muslimin. Sebagai salah satu bentuk pertanggungjawaban pengelola kepada para donatur adalah dengan membuat laporan keuangan yang memuat seluruh transaksi keuangan ponpes. Pencatatan yang dibuat haruslah sesuai dengan Pedoman Akuntansi Pesantren (PAP) yang diterbitkan oleh Ikatan Akuntan Indonesia (IAI) dan bekerjasama dengan Bank Indonesia. Penelitian ini bertujuan untuk meneliti bagaimana pencatatan keuangan di pondok pesantren Al I’tishom, apakah pelaporan keuangan ponpes sudah sesuai dengan PAP guna mengetahui perbaikan yang perlu dilakukan ponpes di bidang akuntansi. Penelitian ini menggunakan metode penelitian deskriptif kualitatif dengan wawancara, observasi, dan dokumentasi. Penerapan PAP pada pelaporan keuangan pesantren dilihat dari tiga aspek: pengungkapan dan pengukuran, penyajian, dan pengungkapan. Temuan penelitian ini menunjukkan bahwa Pondok Pesantren Al I’tishom masih belum menerapkan pelaporan keuangan sesuai dengan PAP.
PENGARUH RELIGIUSITAS DAN NASIONALISME WAJIB PAJAK DALAM MENINGKATKAN KEPATUHAN PAJAK ORANG PRIBADI
Authors: Daniati Nia , Ismatullah Ismet
Published: November 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh religiusitas dan nasionalisme wajib pajak dalam meningkatkan kepatuhan wajib pajak (studi kasus pada wajib pajak orang pribadi di KPP Pratama Sukabumi). Metode penelitian ini adalah metode kuantitatif. Populasi penelitian ini adalah Wajib Pajak orang pribadi pada KPP Pratama Sukabumi. Sampel dalam penelitian ini berjumlah 100 responden yang diambil secara acak. Pencicipan penelitian ini dilakukan dengan menggunakan Analisis Regresi Linier Berganda dan diolah menggunakan software SPSS. Berdasarkan hasil analisis SPSS dapat diketahui bahwa religiusitas tidak berpengaruh terhadap peningkatan kepatuhan wajib pajak orang pribadi di KPP Pratama Sukabumi. Namun, nasionalisme berpengaruh signifikan terhadap peningkatan kepatuhan wajib pajak orang pribadi di KPP Pratama Sukabumi.
PENGENDALIAN PERSEDIAAN WARUNG MAKAN SUNDA CHICKEN BERDASARKAN METODE ECONOMIC ORDER QUANTITY
Authors: Koo Dojeng Meisi , Afandi Rino Kurnia , Munandar Agus
Published: November 2022

Hasil penelitian ini bertujuan untuk membantu menganalisis manajemen persediaan pada warung makan Ayam Sunda. Selama penelitian, metode kualitatif diterapkan dengan melakukan wawancara langsung dengan pemilik warung makan Ayam Sunda untuk mendapatkan data yang digunakan dalam perhitungan persediaan. Berdasarkan wawancara, pemilik warung makan tersebut mengaku belum pernah melakukan pengelolaan persediaan. Oleh karena itu, penelitian ini mencoba menghitung biaya pemesanan dan biaya penyimpanan untuk warung makan Ayam Sunda menggunakan metode EOQ, agar dapat membantu pemilik dalam mengelola persediaannya. Hasil penelitian menunjukkan bahwa metode EOQ dapat membantu warung makan Ayam Sunda dalam meminimalkan biaya pemesanan persediaan. Metode EOQ juga membantu pemilik mengetahui jumlah dan frekuensi pemesanan yang optimal. Hal ini dibuktikan setelah dilakukan perhitungan, terdapat perbedaan biaya pemesanan yang signifikan.
Heterogeneity in School Value-Added and the Private Premium
Authors: Andrabi Tahir , Bau Natalie , Das Jishnu , Khwaja Asim I.
Published: November 2022

Using rich panel data from Pakistan, we compute test score based measures of quality (School Value-Addeds or SVAs) for more than 800 schools across 112 villages and verify that they are valid and unbiased. With the SVA measures, we then document three striking features of the schooling environment. First, there is substantial within-village variation in quality. The annualized difference in learning between the best and worst performing school in the same village is 0.4 sd; compounded over 5 years of primary schooling, this difference is similar in size to the test score gap between low- and high-income countries. Second, students learn more in private schools (0.15 sd per year on average), but substantial within-sector variation in quality means that the effects of reallocating students from public to private schools can range from -0.35sd to +0.65sd. Thus, there is a range of possible causal estimates of the private premium, a feature of the environment we illustrate using three different identification approaches. Finally, parents appear to recognize and reward SVA in the private sector, but the link between parental demand and SVA is weaker in the public sector. These results have implications for both the measurement of the private premium and how we design and evaluate policies that reallocate children across schools, such as school closures and vouchers.
Análisis comparativo de las metodologías para estimar el caudal ecológico en la bocatoma del Brazo-Cuenca del Río Camaná-Majes-Colca. Perú
Authors:   , Ticona Neyra Oscar Enmanuel
Published: November 2022

La presente Tesis tiene por objetivo principal realizar un análisis comparativo entre diversos métodos hidrológicos para estimar el Caudal Ecológico en la Bocatoma El Brazo en la Cuenca del Rio Camaná-Majes-Colca, Perú. La legislación peruana en materia de recursos hídricos define al Caudal Ecológico como el volumen de agua que se debe mantener en las fuentes naturales de agua para la protección o conservación de los ecosistemas involucrados, la estética del paisaje u otros aspectos de interés científico o cultural. Existen diversas metodologías para estimar el Caudal Ecológico para un cuerpo natural de agua, en este caso se trata de un rio que nace de los Andes peruanos y discurre hasta desembocar en la Hoya Hidrográfica del Pacífico. Para estimar el Caudal Ecológico para el tramo en estudio se analizaron diversos métodos hidrológicos empleando una serie histórica de 20 años de datos de caudales en el rio Camaná-Majes-Colca. La fuente de información fue la Estación Hidrológica de Huatiapa, porque posee una serie de datos con suficiente consistencia considerando las coordinaciones efectuadas con el Servicio Nacional de Meteorología e Hidrología del Perú (SENAMHI) que es la institución rectora que opera las Estaciones Hidrológicas. La especie indicadora para estimar el Caudal Ecológico es el Camarón de Rio cuyo nombre científico es el Cryphiops caementarius, que presenta importancia económica debido a que se distribuye en grandes poblaciones en la cuenca, y por ello, su pesca es la principal actividad económica hidrobiológica regional, según el IMARPE (Instituto del Mar Peruano), además, dinamiza la economía de la Cuenca en estudio. Finalmente, es de resaltar, que la importancia de esta Tesis radica en que a la fecha, la Autoridad Nacional del Agua del Perú (ANA), no ha establecido o validado un método para estimar el Caudal Ecológico en cuencas del Perú, por lo cual, la metodología y resultados alcanzados en esta tesis aportará directrices de fácil manejo y aplicación; la cual pueda servir de guía para determinar el Caudal Ecológico en otros tramos en la cuenca en estudio y en cuencas con similares características geomorfológicas en el Perú.
20 años no es nada: autonomía y globalismo en la política exterior argentina (2002-2022)
Authors: Bidondo Abril Camila , Shqueitzer María Florencia , Pasos Lucrecia , Zurita María Delicia , Mendoza Matías Nahuel , Bezus Pablo , Russo Sebastián , Zapata Victoria
Published: November 2022

Este libro nace como un desafío colectivo de los y las integrantes del CeRPI para celebrar los 20 años de las publicaciones de los informes sobre la política exterior argentina de nuestro Centro. A través de un profundo trabajo de recuperación, recopilación y estudio de fuentes de investigación, buscamos generar una nueva instancia de análisis de las estrategias de relacionamiento con el exterior que los diversos gobiernos de nuestro país han establecido a lo largo de las últimas dos décadas de la historia argentina. Así, hemos analizado fuentes de los más variados orígenes, desde las publicaciones de los principales especialistas en la materia, hasta los documentos públicos emanados de las diversas Instituciones del Estado argentino, así como diferentes aportes periodísticos, que permiten reconstruir el contexto de lo estudiado. Pero, por sobre todas las cosas, buscamos hacer un aporte a partir de una relectura de los informes y producciones que se han realizado a lo largo de este tiempo en el seno de nuestro Centro de Reflexión en Política Internacional del Instituto de Relaciones Internacionales. De esta forma, llevamos adelante esta tarea, transformando este desafío en un estimulante trabajo colectivo que, esperamos, sea del agrado del/la lector/a y aporte otro grano de arena del CeRPI al análisis, discusión y seguimiento de la política internacional de la Argentina.
About technogenic transformations of the river network on the Azov-Kuban Plain (Chelbas, Albashi rivers)
Authors: Pogorelov Anatoly , Lipilin Dmitry , Dudkina Alena , Kopaneva Oksana
Published: November 2022

The article analyzes changes in steppe agricultural landscapes in the central part of the Azov-Kuban Plain over the period 2000–2020 using satellite imagery and DEM ASTER GDEM data. in terms of changing the structure of land use and hydrographic characteristics. Most of the agricultural land of the Krasnodar territory, occupying 61.4 % of the region’s territory, is located on the Azov-Kuban plain in the steppe river basins. The territory under consideration with an area of 6268 km², covering the basins of the Chelbas and Albashi rivers, according to its geographical characteristics, is typical from the standpoint of the modern dynamics of agrolandscapes and transformations of the river network. The transformation of agrolandscapes is accompanied by redevelopment and plowing of the territory, mass construction of dams on rivers, violation of the conditions of natural drainage, which leads to the restructuring of water exchange processes in river basins. 19 private river basins have been identified with the definition of land use types on the surface of the basins. In each of the private basins, a land use structure has been established that affects hydrographic indicators, a decrease in the length of watercourses and the density of the river network has been revealed. For 2000–2020 in private basins, the total length of watercourses, due to plowing and redevelopment of the surface, decreased by 1.51–33.14 %, and in general, in the analyzed section of the Azov-Kuban Plain, by 437 km or by 16.5 %. A widespread “die-off” of the upper sections of the river and ravine network was recorded, most noticeable in the peripheral watersheds.
Use of geoinformation technologies in the study of cartometric and morphometric characteristics of lakes in the North Kazakhstan
Authors: Dmitriyev Pavel , Wendt Jan , Teslenok Sergey , Nosonov Arthur , Fomin Ivan , Mushtaykin Anton , Ilkaev Samat
Published: November 2022

The study is devoted to determining the possibilities of using geoinformation systems and technologies for organizing and implementing geoecological monitoring surveys of lakes in the territory of one of the largest lake regions within Kazakhstan—the North Kazakhstan region. The important task of creating a unified electronic catalog of lakes in the study area and placing it in free open access was practically solved. The studied quantitative and qualitative composition of topographic, cartometric, morphometric, hydrological, hydrochemical, hydrobiological, geoecological and other data on the lakes of the region made it possible to use in the catalog a number of cartometric and morphometric indicators common for all areal water bodies. For each of these indicators, a fixed set of values was determined containing information about various aspects of their state. In the procedure for describing and characterizing lakes, such parameters as their length, width, average and maximum depths, features of the bottom topography and its profiles, the length of the coastline and envelope, the degree of indentation of the coastline, the area of the reservoir and catchment area, the volume water mass, the degree of overgrowth of higher emersed vegetation, and others. Based on the analysis of the database of lakes created in Microsoft Excel application and desktop GIS digital mapping software product MapInfo Professional, a series of geoinformation and cartographic materials was prepared, in particular, maps that allow you to quickly obtain the necessary cartometric and morphometric indicators and geoecological characteristics of large lakes in the study region. Thus, by using the potential of graphical visualization of information from a specialized regional GIS in the MapInfo software shell, the possibilities of graphical representation of traditional statistical data of qualitative and quantitative cartometric and morphometric characteristics of lakes are clearly illustrated. The results of the work carried out, the obtained geoinformation and cartographic materials and significant amounts of information accumulated in databases of specialized regional GIS make it possible to organize and carry out a complex of full-scale monitoring studies of lakes for a large set of indicators, which is not only relevant and allows you to track the current state, but also to identify the dynamics of lake ecosystems within the territory of the region.
Acoustic frequency-dependent physical mechanism of sub-MHz ultrasound neurostimulation
Authors: Fan Haixiao , Shimba Kenta , Ishijima Ayumu , Sasaoka Kenya , Takahashi Tsuyoshi , Saka Eigo , Chang Chih-Hsiang , Jimbo Yasuhiko , Azuma Takashi , Takagi Shu
Published: November 2022

Ultrasound allows non-invasive and reversible modulation of neural circuit activity with high spatial resolution. Despite growing interest in clinical applications, the safe and effective use of ultrasound neuromodulation has been limited by a lack of understanding of the physical mechanisms underlying its effects. Here, we demonstrate acoustic frequency-dependent physical effects that underlie ultrasound neuromodulation, where cavitation and radiation forces are the dominant sources of low- and high-frequency stimulation, respectively. We used 39.5 and 500 kHz acoustic frequencies to stimulate cultured neural and glial cells to study acoustic frequency-dependent neural responses. We demonstrate increased evoked responses due to increased cavitation activity at the 39.5 kHz acoustic frequency. In contrast, notable cavitation activity was not detected at 500 kHz despite detection of evoked responses. Our work highlights the dependence of ultrasound neuromodulation on acoustic frequencies, with different physical effects underlying cell responses to low and high sub-MHz acoustic frequency ranges.