bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative analysis of compressed hydrogen losses during its transportation through the pipelines from different materials
Authors: Bolobov V. I. , Petkova A. P. , Popov G. G. , Zlotin V. A. , Latipov I. U. , Sherstneva A. O. , Zhuikov I. V.
Published: April 2023

The authors estimate possible losses of transported compressed hydrogen (P = 10 MPa) due to diffusion through the pipe wall applying Sieverts law and Arrhenius equation and using tabular data on the coefficients of permeability and solubility. The calculation was carried out for pipelines made of various metallic and non-metallic materials at room and elevated temperatures. It is shown that the volume of the diffused gas at T = 298°K (25°С) is only fractions of a percent of the pumped hydrogen volume. At the same time, the biggest loss occurs in a pipeline made of polyethylene (~0.03%), and the most insignificant one in austenitic steels (~10-6%). For carbon and low-alloy steels, the main materials of gas pipelines, these losses are at the level of 10-4–10-5 %. When the temperature rises to 683°K (410°C), the losses in steel pipelines increase to 0.25%, in polymer pipelines to 20%.
Long-term high-temperature exposure effects on mechanical properties and structure of the 42XNM alloy after neutron irradiation in the VVER-1000. Part 1. Mechanical tests
Authors: Gurovich B. A. , Frolov A. S. , Kuleshova E. A. , Fedotov I. V.
Published: April 2023

The paper presents the results of mechanical tests of ring specimens made of the 42XNM alloy after irradiation as part of the control and protection system of the VVER-1000 reactor to a damaging dose of ~12 dpa at a temperature of ~350°C and subsequent isothermal annealings in the temperature range of 400– 1150°C (heating and holding for ~2 h). A model was constructed and validated by the finite element method, it describes the mechanical characteristics of irradiated and non-irradiated samples from the 42XNM alloy during tests in the temperature range from 500 to 1000°C. The model was used to plot the temperature dependences of the maximum local plastic deformation and the yield strength of the material under study.
Structure forming processes in economically alloyed shipbuilding steel of 890 MPa yield strength level with a bainite-martensite structure when microalloyed with vanadium
Authors: Sych O. V. , Korotovskaya S. V. , Novoskoltsev N. S. , Khlusova E. I.
Published: April 2023

The kinetics of growth of austenite grains during heating, the features of the processes of dynamic and static recrystallization occurring under various temperature-deformation regimes of hot plastic deformation have been studied. Phase transformations have been studied during continuous cooling of hot-worked austenite in a low-carbon low-alloy steel with a guaranteed yield strength of 890 MPa. As a result, the boundary temperature-deformation conditions for the formation of a finely dispersed bainite-martensite structure were established, on the basis of which technological modes for the production of thick-plate rolled products in industrial conditions were developed. The structure and properties of rolled sheets 35 mm thick from shipbuilding sparingly alloyed steel of strength level 890 are presented.
Long-term high-temperature exposure effects on mechanical properties and structure of the 42XNM alloy after neutron irradiation in the VVER-1000. Part 2. Structural studies
Authors: Gurovich B. A. , Frolov A. S. , Kuleshova E. A. , Maltsev D. A. , Fedotov I. V. , Safonov D. V.
Published: April 2023

The paper presents the results of structural studies of ring specimens made of the 42XNM alloy after irradiation as part of the control and protection system of the VVER-1000 reactor to a damaging dose of ~12 dpa at a temperature of ~350°C and subsequent isothermal annealings in the temperature range of 400– 1150°C (heating and holding for ~2 h). It is shown that during long-term isothermal annealing, a change in the phase composition of the alloy is observed, dislocation structures and grain-boundary segregations are annealed, and porosity evolves. It has been confirmed that decrease in the plastic properties of the 42XNM alloy after irradiation and subsequent isothermal annealing in the temperature range of 400–1000°C could be explained by the formation of precipitates of the second phases (zones of discontinuous decomposition of the solid solution with the release of α-Cr particles along the grain boundaries) and pores at the grain boundaries.
On the ability of polymers to self-lubrication in metal – polymer friction pairs
Authors: Sedakova E. B. , Li Syanshun , Zharov V. E. , Breki A. D. , Pozdnyakov A. O. , Smirnov A. A.
Published: April 2023

Results of comparative research of wear resistance of polytetrafluoroethylene (PTFE), polyetheretherketone (PEEK), ultrahigh molecular weight polyethylene (UHMWPE) and polyamide 6 (PA6) in friction pairs with 18Kh2N4МА, 08Kh18N10Т and 40Kh13 are presented. Self-lubricating ability of polymers was determined by the contact pressure value corresponding to the upper border of the diapason, in which the effect of stabilization of linear wear intensity values and by the length of this diapason along the axis of loads is shown. Carbon steel 45 was used as a base steel in the comparison. PEEK, UHMWPE and PA6 friction pairs show higher values of intensity of linear wear but decrease in ability to self-lubrication. However in friction pair PTFE – steel 18Kh2N4МА with the prevailing content of nickel (about 4%), expansion of a range of stabilization of linear wear intensity is observed. In friction pairs PTFE with steel 40Kh13, containing a considerable percentage of chrome (13%), in absence of nickel, and with steel 18Kh2N4МА containing a complex of nickel and chrome (10% and 18%, respectively), the least wear resistance and ability to self-lubrication of polymer are marked. Temperatures on polymer tribocontact corresponding to ranges of wear stabilization loadings in researched friction pairs are determined.
Filosofia, psicanálise & contemporaneidade
Authors: Fachini Julio , Almeida de Lima Guilherme
Published: April 2023

Filosofia, Psicanálise & Contemporaneidade – Volume 3 traduz filosoficamente o resultado de uma sistematização contínua, a partir do trabalho de pesquisadores implicados nas problemáticas que a contemporaneidade suscita dentro da teoria e da clínica psicanalítica. O núcleo investigativo desta obra é o desdobramento dos pressupostos psicanalíticos traçados em uma perspectiva temporal e amparados por uma retrospectiva teórica e conceitual. Este volume possui como objetivo iluminar o significante Contemporaneidade com o olhar do passado, mas sem perder, no entanto, o horizonte e o destino epistemológico, metodológico e conceitual da psicanálise. Filosofia, Psicanálise & Contemporaneidade, pois trabalhar com a psicanálise implica, naturalmente, contemplar a perspectiva cronológica e temporal da existência humana. Para Freud, acolher o presente é sempre acolhê-lo em sua historicidade, isto é, em um presente historicizado. Abordar o contemporâneo e a filosofia nos conduz, naturalmente, ao Cronos, pois precisamos encarar os conceitos em suas articulações inevitavelmente cronológicas. No entanto, mais do que encará-los em sua cronologia temporal, também podemos contemplar o tempo em filosofia da psicanálise a partir de um tempo não cronológico, ou seja, o tempo de Kairós: um tempo deslocado, oportuno, memorável, catártico e inconsciente. Esta obra é efeito da aliança entre pesquisadores que carregam um resíduo de Cronos e de Kairós, e que, encarando a temporalidade desenvolvem articulações entre a psicanálise e temas como: epistemologia, metapsicologia, religião, arte, educação, clínica, sociologia, política, e cultura.
Evolución del procesamiento natural del lenguaje
Authors: Giraldo Forero Andres Felipe , Orozco Duque Andrés Felipe
Published: April 2023

El lenguaje escrito no ha sido ajeno a los cambios culturales y tecnológicos. Por ejemplo, la invención de la imprenta en el siglo XV, o el desarrollo de los computadores personales y los teléfonos inteligentes en las últimas décadas, fueron hitos que marcaron drásticamente su evolución. De manera paralela al desarrollo del lenguaje, la evolución de la computación y el surgimiento de algoritmos inteligentes, capaces de tomar decisiones han tenido avances impresionantes en los últimos años formando una nueva área de estudio conocida como inteligencia artificial IA, considerada por muchos como la siguiente gran revolución.   La integración de las técnicas de IA con el fin de interpretar, manipular y comprender el lenguaje humano da como resultado la rama del procesamiento natural del lenguaje PNL, la cual, teniendo en cuenta los últimos avances en modelos de generación de lenguaje, se puede convertir en el próximo gran hito en cuanto al lenguaje escrito. Los primeros algoritmos de PNL estaban basados en reglas, posteriormente se empezó a utilizar esquemas de clasificación supervisada basados en modelos como la regresión logística, las máquinas de soporte vectorial, los modelos ocultos de Markov, o los árboles aleatorios condicionales, entre otros. El problema de los modelos de clasificación tradicionales es que los mismos están orientados a evaluar cada palabra, o las relaciones entre cada palabra y la palabra anterior, pero no capturan el contexto de las mismas en una frase completa.
inclusão digital de pessoas com deficiência por intermédio da apropriação tecnológica
Authors: Simões Aguiar Aline , Antonio Stefanuto Vanderlei
Published: April 2023

Este artigo versa sobre um relato de experiência docente resultante de um projeto-piloto intitulado “Curso de Informática Básica para Pessoas com Deficiência (PcD)”, com o objetivo de descrever a relevância deste curso para os cursistas, demonstrando os desafios e avanços decorrentes do uso das ferramentas tecnológicas, assim como as conquistas provenientes das relações interpessoais estabelecidas entre alunos aprendizes  e alunos monitores. A pesquisa está ancorada na teoria do “computador na educação” de Valente (1991), “educação inclusiva” de Mantoan (2003), “Tecnologias de Informação e Comunicação (TICs)” em Souza, Santos e Schlunzen (2012), entre outros. Adotou-se como metodologia a pesquisa de abordagem qualitativa, descritiva de um relato de experiência. A coleta de dados realizou-se por meio da observação participativa passiva, usando como instrumento para anotações um diário de bordo. Os resultados evidenciaram a necessidade de formação de alunos-monitores, produção e adequação didático-metodológicas e de espaço arquitetônico, bem como o uso de instrumentos específicos, como: apostilas, software e hardware.
Luta Marajoara na escola
Authors: Santos Carlos Afonso Ferreira dos , Andrade Welison Alan Gonçalves , Freitas Rogério Gonçalves de
Published: April 2023

Este relato de experiência versa sobre uma sequência pedagógica com o tema Luta Marajoara, proposta para uma turma do 3º ano do ensino fundamental de uma escola pública do município de Soure, Arquipélago do Marajó, Pará. O objetivo foi apresentar perspectivas didático-pedagógicas relacionadas à Luta Marajoara e contribuir para sua sistematização nas aulas de Educação Física. A sequência foi distribuída em três aulas contempladas pelos aspectos culturais e tradicionais; pelos fundamentos e ações motoras; por atividades lúdicas e jogos de oposição; e, por fim, pela realização de um mini torneio. Observou-se que o ensino da Luta Marajoara foi um dispositivo para os alunos valorizarem sua própria cultura, assim como refletir sobre o modo como desenvolvemos nossas identidades. A delimitação dos objetivos, a organização das estratégias metodológicas e a adoção de instrumentos/recursos alternativos para o ensino de Luta Marajoara resultou em uma experiência positiva e criativa para a formação dos estudantes.
Tensões, aprendizagens e reflexões no trato com as lutas na escola
Authors: Furtado Renan Santos
Published: April 2023

te estudo trata-se de um relato de experiência com o conteúdo lutas em aulas de Educação Física no Ensino Médio da Escola de Aplicação da Universidade Federal do Pará. Como objetivo central deste estudo, buscamos apresentar algumas reflexões provenientes de tensões teórico-práticas entre certos conceitos estabelecidos no campo acadêmico, tais como: lutas, artes marciais e esportivização e manifestações como a Luta marajoara, o Huka-huka e as Artes Marciais Mistas (MMA). Metodologicamente, com base na perspectiva do trabalho intelectual concebido como artesanato oriundo da imbricação formativa entre experiências de vida, profissionais e teóricas (MILLS, 2009), partimos do confronto entre fontes empíricas de nossas atividades de ensino, junto com uma literatura especializada dos campos da Educação Física, Lutas e Sociologia do esporte. Do ponto de vista das principais aprendizagens produzidas junto aos estudantes, pontuamos que: 1) A luta marajoara e o huka-huka transcendem o conceito clássico de lutas, ainda que estejam englobados nele, mas, a explicação aprofundada dessas práticas culturais necessita explorar os contextos e o simbolismos presentes nessas manifestações. 2) O MMA se apresenta como uma esportivização de novo tipo, sendo o conceito clássico de esportivização produzido no âmbito da Sociologia do esporte do século 20 insuficiente para explicar esse fenômeno.
Influencia de algunos factores en la fermentación ácido láctica del polen apícola
Authors: Benavides Guevara Ruth M. , Quicazan Marta C. , Ramírez Toro Cristina
Published: April 2023

El polen es un recurso fundamental para la nutrición de las abejas por su alto valor nutricional, tanto en proteína y grasa; estos insectos lo recolectan de las flores y aportan a la colmena (polen apícola), donde desarrollan un bioproceso natural, al inducir una fermentación del polen dentro de la colmena, generando el pan de abejas, alternativa que se considera sustentable para la alimentación del ser humano. En el presente estudio se evaluó a escala de laboratorio la influencia de algunos factores en la fermentación ácido láctica de esta matriz vegetal. Primero se caracterizó la matriz vegetal, segundo se evaluó las diferentes relaciones como polen: agua (1:1 y 1:2), adecuación de pH con NaOH 5N (neutralizado y sin neutralizar) hasta llegar a un pH cercano a 6.0, adicional se fermento con tres cultivos iniciadores L.acidophilus, Bifidobacterium lactis y Yomix@205, posterior, se efectuó un seguimiento de la acidificación, pH y recuento de células viables para analizar las diferentes cinéticas a través del tiempo. Se encontró que el polen es rico en proteína 25.362±0,38% y en grasa 7.27±0,02%, respecto a la fermentación se encontró un cambio significativo para la relación polen: agua 1:2 neutralizado, al ser un comportamiento típico de fermentación al disminuir el pH e incrementar la acidez para cada uno de los tres cultivos starter. Posterior se realiza recuento de células viables al punto final de la fermentación, encontrando que el cultivo Bifidobacterium lactis, presento mayor concentración de microrganismos a las 47 horas de 2.26 x109 unidades formadoras de colonia/g, en comparación a otros cultivos.
Diseño e implementación de un laboratorio virtual remoto como estrategia de la enseñanza de la física general en el servicio del componente practico de la Universidad Nacional Abierta y a Distancia
Authors: Benitez Rodriguez Edson Daniel , Diaz Raga Hugo Hernando
Published: April 2023

The purpose of this document is to originate and publicize the ICT-Mediated Educational Project carried out at UNAD as a pilot center of this process, applying this service in the implementation of a Virtual Remote Laboratory hereinafter LVR, to measure the impact generated in universities that do not have a laboratory service and therefore it is proposed in a virtual way to generate greater coverage in rural areas. The pertinent process regarding the Mesocurricular approach since it is applied to the Institutional field and designs educational experiences of various kinds, therefore, the option of teaching General Physics as a practical component is offered, supporting some significant points in the basic teaching of physics . The aforementioned project incorporates simulated practices, and E- learning is complemented by the E-training practice known as "Digital Practice", which includes a real-time simulator (Labview licensed software) linked by online web where the electronic elements to perform the connection using the Arduino board, they will be useful to link them remotely. For that reason, it is a situation that causes great interest in the academic community in providing this type of L.V.R service and that there is the possibility of providing this service to educational institutions in the future through the UNAD.
Identificación del nivel de la gestión tecnológica del sector metalmecanico en la ciudad de Duitama
Authors: Rincón Parra Nidia Stella , Garzón Martínez Sonia Patricia , Florez Lina Maria
Published: April 2023

Technological Management can be conceived as the meeting of vital production actions supported by knowledge and expertise, this interaction adds value to the products and determines the business differentiating factor. The objective of this article is to evaluate the level of technological management in which the metal-mechanic sector is found in the city of Duitama to propose management actions and strategies that project it competitively, the type of research used is non-experimental descriptive, with finite population sample of 131 companies, using proportional stratified sampling, taking Technology Management as a system as the main axis in this analysis, and as study categories the input variables to the system that, from operationalization, become evaluation criteria of the levels of technological management, which is found in the theoretical foundation; through a diagnostic analysis that allows determining the level of the current situation of the sector, which places it at level 2 medium-low, which means that the criteria involved in Technological management are not taken into account as a support for strategic actions of their organizations. reaching the conclusion that technology management becomes an organizational and sectoral challenge.
Características pedagógicas, didácticas y tecnológicas para el diseño de sistemas gamificados basados en experiencia de usuario en Educación virtual
Authors: Munévar Pablo Alexander , Pedraza Clara Esperanza , Aranda Diego Fernando , Granados Javier Reina , Buitrago Paola Andrea , Samper Luis Fernando , Montenegro Carlos Enrique , Gaona Paulo Alonso
Published: April 2023

This paper is part of the progress results of a research project supported by MinCiencias and the Antioquia Government, which focuses on the development of a gamified system, which is theoretically supported by emerging and current trends such as Deep Learning, artificial intelligence, big data and user experience focused on strengthening quality in virtual education.

 

Under a SCRUM-type methodology, a set of phases is defined, ranging from exploration, identification of variables and categories, system development, piloting, and validation to be brought to a level of technological maturity type TRL3. This methodology has generated the work path and design from architectural and modeling aspects of the development of a gamified system, from its idea to its development and implementation.

 

The relationships between the results of the articulation between engineering, education and the sciences of social behavior, are approached from emerging models, and exponential technologies that allow establishing favorable elements for the development of platforms, applications and pedagogical and didactic innovations which, as in this case, strengthen the processes focused on retention and permanence as a factor associated with reducing student dropout.
El incumplimiento fiscal en las grandes empresas
Authors: Pérez Feria Lizbeth , García Álvarez Aída Dinorah , Martínez Prats Germán
Published: April 2023

This investigation refers to the tax non-compliance that exists in Mexico given that it is a situation that commonly occurs before the Tax Authorities, since this is due to the non-payment of tax and that the companies do not present through their declarations, since they do not inform their entire income. The affectation is documented in the Public Treasury, causing that there are not enough resources to satisfy the needs of society.

The objective of this research is to deepen the causes why companies come to evade certain obligations that they have with the State, as well as the consequences that this entails and to compare the rates of tax collection in the last 5 years, analyzing the impact that has caused the COVID-19 pandemic.

The methodology is documentary, taking into account the recovery of information with a qualitative approach, since it is the one that is oriented to the production of descriptive data, selecting different types of search sources through the reading of documents such as; books, magazines, etc

The findings of this investigation indicate that through the low collection in recent years they affect society and as a consequence they do not meet the needs that they require. That is why it is important to make citizens aware from a young age about a tax culture in which they must have certain obligations when they reach the age of majority.
Estrategias de marketing en el mercado de antojitos regionales en Tabasco Caso: handmade snacks restaurant.
Authors: Baeza Priego María de la Cruz
Published: April 2023

Today there is a diversity of commercial strategies that companies carry out with the desire to remain in the markets in which they compete, it has been observed mostly that large companies have been able to implement risky and effective commercial strategies; in the case of PyMES whose investment in this area is usually scarcer due to budget issues and in some others due to ignorance on the subject, few are the companies of this type that choose a commercial strategy with a medium-term vision.

 

This scientific article aims to analyze the commercial strategies that can be implemented by the company Handmade Snacks Restaurant located in Villahermosa, Tabasco, according to its strategic objectives to remain in the market as a leading company in its field.  As a study methodology, the analysis of the case is used using primary data collection methods, so it proceeds basically from the observation and interview of the study subjects, as well as the application of a consumption preference survey of their customers and possible expansion of the restaurant in other locations in the State of Tabasco.

The results of the research show that the strategies that Handmade Snacks Restaurant can potentially apply are the differentiation strategy, the blue ocean strategy, using mostly direct marketing, given the conditions and preferences of its customers.
Las nuevas tecnologías y su implementación en el sistema educativo
Authors: Xicoténcatl Valencia Martha Libny
Published: April 2023

Education is an essential part for social development, this is because through it there is training in which people learn values as well as obtain various skills through the knowledge acquired through education, with the passage of time education has had great changes this is due to the various tools and systems that have emerged to have a greater scope on the people, so that they can understand their environment more efficiently to develop their skills; The birth and implementation of technology has generated great changes within society has brought with it a great variety of tools as well as the implementation of technological systems that allow human activities to be developed more efficiently as well as in less time, reducing costs and labor so that since its arrival society has been evolving on a recurring basis. The objective of the article is to show that new technologies have had a great relevance in the educational system, which with its implementation has brought great benefits for teaching and learning that develops around education.
The existence and urgency of administrative efforts in the administrative justice and regulation
Authors: Ridwan Ridwan
Published: April 2023

One of the elements in a legal state is the separation or division of power (machtenscheiding), in the sense that each state institution is formed with separate functions and powers or is divided independently and does not interfere with each other (van der Burg et al., 1985). One of the characteristics of the concept of the welfare state is the government’s obligation to seek the general welfare, or bestuurszorg (Utrecht, 1985). Along with the government’s obligation to strive for the welfare of the community, the goal is that the government not only implements the legal provisions that have been made by the legislature but is also attached with authority to make laws and regulations, especially in the form of implementing regulations, policy regulations, and various decisions. The method used in this research is to use a descriptive-analytical approach, which is used to examine the provisions of the relevant legislation and literature. In accordance with the doctrine of Administrative Law, administrative efforts are part of the government’s task. The importance of administrative efforts, among others, lies in their complete examination, which includes policy and legal aspects and can immediately change, correct, or even revoke disputed decisions.
CSN5 plays a role in asthma via its interaction with PD-L1
Authors: Jang An-Soo , Choi SeonMuk , An MinHyeok , Lee Pureun-Haneul , Hwang DaYeon , Park Shinhee
Published: April 2023

Background The COP9 signalosome (CSN) is a highly conserved
protein complex composed of eight subunits. The individual CSN subunits
play essential roles in cell proliferation, signal transduction
modulation, gene transcription, angiogenesis, and microenvironmental
homeostasis. However, the exact role of CSN subunit 5 (CSN5) in
bronchial asthma remains unclear. Methods The potential link
between CSN5 and bronchial asthma was investigated in ovalbumin
(OVA)-induced asthma in mice. Samples from HMVEC-L cells treated with
Dermatophagoides pteronyssinus (Derp1) and CSN5 small interfering RNA
were collected to determine the expression of NF-κB, IκBα, IKKβ, PD-L1,
and CSN5. Furthermore, plasma CSN5 levels in asthma patients (stable and
exacerbated states) were analyzed. Results Plasma CSN5 levels
were higher in patients with exacerbated asthma (n = 19) than in healthy
controls (n = 10) or patients with stable asthma (n = 10). The CSN5
level was correlated with lung function in patients with asthma. CSN5
silencing in HMVEC-L cells reduced the NF-κB protein level at 4 h and
PD-L1 level at 4 h, 8 h, and 24 h after Derp1 treatment. Goblet
cell hyperplasia, lung fibrosis, and the levels of CSN5, PD-L1, NF-κB,
p-IκBα, p-IKKβ, IL13, and INFγ proteins increased at 33 and 80 days in
OVA-sensitized/challenged mice compared with control mice, but these
changes were reduced by PD-L1 inhibitor treatment. Conclusions
The results indicate that CSN5 interacts with PD-L1 in asthma and may be
a potential target for asthma treatment.
Breaking the ‘Don’t Eat Me’ Signal: In Silico Design of CD47 Directed Peptides for Cancer Immunotherapy
Authors: Sobhia Masilamani , Laddha Kapil
Published: April 2023

The main cause of mortality globally is cancer and despite there being a
number of therapies available to treat cancer, the success in finding
one is like finding a needle in haystack. Immunotherapy emerges to be
the one of the needles in this haystack of cancer treatment.
Immunotherapeutic agents enhance the immune response of patient’s body
to tumor cells One of the immunotherapeutic targets, Cluster of
Differentiation 47 (CD47), releases the “don’t eat me” signal when it
binds to its receptor, Signal Regulatory Protein (SIRPα). Tumour cells
use this signal to circumvent the immune system, rendering it
ineffective. In order to stop tumour cells from releasing the “don’t
eat me” signal, the CD47-SIRPα interaction is specifically targeted in
this study. In order to do so, in silico peptides were designed
based on the structural analysis of the interaction between two proteins
using point mutations on the interacting residues with the other amino
acids. The peptide library was designed and docked on SIRPα using
computational tools. Later on, after analysing the docked complex, best
of them were selected for MD simulation studies of 100 nanoseconds.
Peptides were further analysed after MD studies to narrow down to the
possible potential anti-SIRPα peptides.
NCEDs drive Rising but not Peaking abscisic acid profiles in diverging conifer species
Authors: Rizzuto Gabriele , Wang Dapeng , Chen Jinhui , Hung Tin Hang , Fitzky Anne Charlott , Flashman Emily , MacKay John J.
Published: April 2023

Climate change poses one of the greatest threats to forest ecosystem
integrity. An improved understanding of how trees respond to extreme
climatic events is crucial to find new ways of managing forests in the
face of global warming. In this work we look at the genetic mechanisms
governing the production of the plant hormone abscisic acid (ABA), which
safeguards plant’s water status by the means of two divergent modes
across different conifer species. We find that conifers from
evolutionary ancient families adopt a conservative water strategy during
drought by accumulating high levels of ABA in their leaves, which we
describe as Rising types, while more derived species accumulate the
hormone in a transient manner and allow for greater water loss,
accordingly to a Peaking type. Moreover, we provide evidence that these
contrasting strategies may be controlled by divergent gene expression,
including sequences involved in the biosynthetic and catabolic pathways
of ABA, and especially nine- cis-epoxycarotenoid dioxygenases (
NCEDs). Our results help to clarify the genetic and physiological
bases of iso/anisohydric responses. We believe that studying these and
other related genes that regulate plant water status, such as those
involved in ABA storage and mobilisation, may help foresters develop and
grow more resistant trees.
Structure and Elasticity of Aorta In Children with Chronic Renal Failure and Relation to Hydration Status of the Patients
Authors: Sarisoy Ozlem , Arıcı Sule , Bodur Ece Demirci , Tezel Oguzhan , Alpay Harika , Akalin Figen
Published: April 2023

Introduction: We aimed to evaluate cardiovascular risks and
influencing factors by measuring aortic elasticity parameters and
carotid intima thickness in children with cronic renal failure (CRF),
and also evaluated the hydration status of patients with Bioimpedance
spectroscopy (BIS) measurements and investigated the effect of hydration
status on vascular functions. Metods: The study group consisted
of 38 patients with CRF, their ages between 6 to 20 years (mean ± SD=
13.34 ± 3.74), of which 16 were girls and 22 were boys. The control
group, which consisted of 31 healthy children between 7 and 16.5 years
of age (mean ± SD= 12.1± 2.92), 16 girls and 15 boys). Left ventricular
end-diastolic, end-systolic, left atrial diameters, interventricular
septum, and left ventricular posterior wall thickness were measured.
Systolic and diastolic diameters of the aortic annulus and aorta at each
level were obtained; z-scores, aortic strain, distensibility, stiffness
index were calculated. Carotid intima-media thickness and flow- mediated
dilatation were studied. Bioimpedance spectroscopy was performed to all
patients. Results: Interventricular septum and left atrial
(p=0,002, p=0,013), sinus valsalva and sinotubular junction z scores
(p=0,009, p=0,012) were found to be higher and distensibility and strain
decreased, stiffness index increased in the abdominal aorta of patients
with CRF (p=0,007, p=0,002, p=0,004). Patients with CRF had
statistically significant over-hydration. Conclusion: Vascular
wall changes that affect the elastic properties of the aortic wall begin
to develop in childhood in patients with CRF. This is related to the
severity of the disease and the patient’s hydration status.
Computational Study for the Identification of Novel Therapeutic Targets in Haemophilus influenzae by Subtractive Genomics Approach
Authors: Kumar Harish , Sobhia M. E.
Published: April 2023

Haemophilus influenzae, a gram-negative, facultative anaerobic
coccobacillus, is a member of Pasteurellaceae family. It causes a
variety of invasive and non-invasive bacterial infections known as H.
influenzae infections. The rise in antibiotic resistance alarms for the
identification of novel therapeutic targets for treating H. influenzae
infections. The emerging trends in the field of Pharmacoinformatics have
aided in the prediction of novel putative therapeutic targets.
Subtractive Genomics is a simple yet powerful approach for the
identification of novel therapeutic targets for a bacterial pathogen.
The purpose of the current study is to identify novel putative
therapeutic targets for the treatment of H. influenzae infections. In
this study, the core proteome of 72 strains of H. influenzae was
analysed, and 115 proteins were found to be unique and non-homologous to
the human proteome. Further screening of these proteins led to
identification of 25 proteins involved in the 29 unique metabolic
pathways of bacteria. We have identified five novel putative therapeutic
targets for H. influenzae bacteria that are unique, non-homologous to
the human proteome, essential for the bacterial survival, and involved
in the unique metabolic pathways of bacteria.
Precursor deconvolution error estimation: the missing puzzle piece in false discovery rate in top-down proteomics
Authors: Jeong Kyowon , Kaulich Philipp T. , Jung Wonhyeuk , Kim Jihyung , THOLEY Andreas , Kohlbacher Oliver
Published: April 2023

Top-down proteomics (TDP) directly analyzes intact proteins and thus
provides more comprehensive qualitative and quantitative
proteoform-level information than conventional bottom-up proteomics that
relies on digested peptides and protein inference. While significant
advancements have been made in TDP in sample preparation, separation,
instrumentation, and data analysis, reliable and reproducible data
analysis still remains one of the major bottlenecks in TDP. A key step
for robust data analysis is the establishment of an objective estimation
of proteoform-level false discovery rate (FDR) in proteoform
identification. The most widely used FDR estimation scheme is based on
the target-decoy approach (TDA), which has primarily been established
for bottom-up proteomics. We present evidence that the TDA-based FDR
estimation may not work at the proteoform-level due to an overlooked
factor, namely the erroneous deconvolution of precursor masses, which
leads to incorrect FDR estimation. We argue that the conventional
TDA-based FDR in proteoform identification is in fact protein-level FDR
rather than proteoform-level FDR unless precursor deconvolution error
rate is taken into account. To address this issue, we propose a formula
to correct for proteoform-level FDR bias by combining TDA-based FDR and
precursor deconvolution error rate.
Unleashing the Potential of Stem Cells for Targeted Anti-Microbial Treatment
Authors: Yetgin Ali
Published: April 2023

Infectious diseases continue to pose a serious threat to human health as
a result of the spread of antibiotic resistance, underscoring the urgent
need for new and focused therapeutic approaches. Due to their
regenerative and immunomodulatory capabilities, stem cells have emerged
as a potential source for the development of antimicrobial therapies.
This paper reviews the potential of stem cells as a targeted strategy
for combating infections, focusing on their ability to differentiate
into specific cell types that can directly target and eliminate
microorganisms, as well as their capacity to modulate the immune
response and enhance host defenses. The article discusses the challenges
and opportunities associated with the clinical implementation of
antimicrobial therapies derived from stem cells. Among these obstacles
are the need for uniform protocols for cell isolation, expansion, and
delivery, as well as the significance of rigorous evaluations of safety
and efficacy. Given all relevant factors, it is our belief that the
application of stem cells as a targeted antimicrobial approach holds
significant potential for the development of effective and enduring
therapeutic interventions for infectious diseases.
Characteristics and Mechanism of Bubble Initiation in Transformer Oil Induced by Vibration
Authors: Guo Chong , Zhang Qiaogen , Zhou Junjie , Wang Shaoqi , Sun Yunhan , Zhang Zhetao
Published: April 2023

Operating experience has shown that vibration can cause pressure
fluctuations and initiate bubbles at the oil gap, which seriously
threatens the insulation properties of oil-immersed power equipment. The
main aim of this study was to determine the characteristics and
mechanism of bubble initiation at the transformer oil gap under
vibration in this paper. The results show the existence of the
vibration-dependent bubbling phenomenon at the oil gap. Interestingly,
bubbles initiate during the process of gap expansion, and the evolution
of bubble morphology was further analyzed. The threshold characteristic
of the bubble initiation process was found, and the relevant influencing
factors were experimentally obtained. In the range considered in this
study, higher gas content, higher temperature, and lower moisture
content are conducive to bubble initiation at the oil gap under
vibration, while vibrational frequency does not affect the threshold
characteristic of bubble initiation process. The vibration-dependent
bubbling phenomenon can be attributed to the vibration-induced
cavitation process caused by the decrease in pressure at the oil gap.
The influence mechanism of the above factors on the threshold
characteristics of bubble initiation was further discussed. This study
contributes to providing a reference for risk assessment of abnormal
vibration of oil-immersed power equipment.
Introducing Machine Learning in Auditing Courses
Authors: Huang Feiqi , Wang Yunsen
Published: April 2023

The advances in machine learning have gained close attention from audit practitioners and standard setters. However, fewer than half of accounting programs teach predictive analysis, including machine learning. To develop students’ knowledge and skills of machine learning in auditing applications, this study introduces machine learning to the accounting curriculum and presents a novel hands-on approach for teaching machine learning in auditing courses. The objective is to provide students who have no statistics background and programming skills with the basic knowledge of machine learning and hands-on exercises for predicting auditing tasks. In addition to instruction manuals, this study demonstrates an implementation of machine learning exercises in a graduate-level auditing course.
Mitochondria-Associated Molecular Mechanisms in Endometriosis - A Mini Review
Authors: W Tana
Published: April 2023

Endometriosis is a multifaceted disorder, with a variety of factors and processes at play. Research is currently investigating the influence of genetics, epigenetics, signaling pathways, and oxidative stress in its etiology. It is clear that these elements have an effect on the mitochondria in different cells, which are responsible for regulating ROS production, energy metabolism, and signal transduction in endometriosis. An assessment of mitochondrial-related molecular mechanisms in endometriosis is in progress.
Implementasi Perbaikan Kualitas Citra Tanaman terhadap Perbedaan Kamera untuk Prediksi Pigmen Fotosintesis berbasis Machine Learning
Authors: Tjokro Atmodjo Felix Adrian , Prilianti Kestrilia Rega , Setiawan Hendry
Published: April 2023

Implementation of Plant Image Quality Improvement based on Machine Learning on Camera Variation to Predict Photosynthetic Pigments. Pigments are natural dyes found in plants and animals. In photosynthesis, there are 3 essential pigments: chlorophyll, cartenoid, and anthocyanin. Pigment analysis can be performed with High Performance Liquid Chromatography (HPLC) and a spectrophotometer. However, HPLC and spectrophotometers require high resources and time. Thus, the Fuzzy Piction Android application built using the FP3Net model is the best choice in pigment prediction since it is low on cost and accessible. However, the Fuzzy Piction produces different performance, which is affected by light conditions and camera specifications. The experiment used ten sample images for Jasminum sp., P. betle, Syzygium oleina of green and red variations, and Graptophyllum pictum leaves with three smartphone cameras and three lighting levels. Improvements using 3D-TPS produced the best SSIM values in the range of 0.9191 – 0.9797 for images Syzygium oleina of green and red variations leaves, and the predicted MAE value of pigment was 0.0296 – 0.0492.Keywords: 3D-TPS, plant leaves, pigment, image quality improvement
 
Pigmen merupakan pewarna alami yang ditemukan pada tumbuhan dan hewan. Dalam proses fotosintesis terdapat tiga pigmen yang penting, yaitu klorofil, kartenoid, dan antosianin. Analisis pigmen dapat dilakukan dengan Kromatorafi Cair Kinerja Tinggi (KCKT) dan spektrofotometer. Namun,KCKT dan spektrofotometer membutuhkan sumber daya dan waktu yang tinggi. Sehingga, aplikasi Android Fuzzy Piction yang dibangun menggunakan model FP3Net mejadi pilihan dalam prediksi pigmen dengan biaya murah dan mudah. Akan tetapi, aplikasi Android Fuzzy Piction menghasilkan kinerja yang berbeda-beda yang dipengaruhi oleh kondisi cahaya dan spesifikasi kamera. Dilakukan percobaan dengan mengambil sepuluh sampel citra daun dari empat varietas tanaman yaitu, pucuk merah, daun ungu, melati, dan sirih. Citra diambil dengan tiga kamera smartphone dan tiga tingkat pencahayaan yang berbeda. Perbaikan yang dilakukan menggunakan algoritma 3D-TPS menghasilkan nilai SSIM terbaik pada rentang 0.9191 –0.9797 untuk citra daun pucuk merahdan nilai MAE prediksi pigmen sebesar 0.0296 –0.0492.Kata Kunci: 3D – TPS, daun tanaman, pigmen, perbaikan kualitas citra
The Research Development of Tax Avoidance: A Literature Review
Authors: Safitri Rema , Widarjo Wahyu
Published: April 2023

This study looks at ninety articles about tax avoidance from seventy well-known national and international journals. This study looked at articles about tax avoidance from 2017 to 2022 and put them into groups based on the subject and method. China Journal of Economics, Management, Accounting, Journal of Accounting Studies, Journal of International Accounting, Auditing, and Taxation the International Journal of Innovation, Creativity, and Change has published most of the articles about avoiding taxes. The results of this study show that from 2017 to 2022, corporate governance, political connections, profitability, corporate social responsibility, and earnings management will be the most common ways for companies to avoid paying taxes. Most articles about tax avoidance have been published in the China Journal of Economics, Management, and Accounting, the Journal of Accounting Studies, the Journal of International Accounting, Auditing, and Taxation, and the International Journal of Innovation, Creativity, and Change. The results of this study show that from 2017 to 2022, corporate governance, political connections, profitability, corporate social responsibility, and earnings management will be the most common factors related to tax avoidance. Between 2017 and 2022, researchers will use the quantitative method the most, while the effective cash rate will be the most common way to measure tax evasion. This study has limitations, including the fact that it only includes data from 2017 to 2022.
Pengembangan Multimedia Interaktif Berbasis Aplikasi Smart Apps Creator 3 Pada Mata Pelajaran IPA Kelas VII Di SMP
Authors: Berta Aditya , Bentri Alwen
Published: April 2023

Pembelajaran di sekolah pada saat ini mulai disesuaikan dengan perkembangan teknologi informasi, sehingga terjadi perubahan dan pergeseran paradigma pendidikan serta meningkat penggunaan media dan teknologi. Penelitian ini bertujuan untuk menghasilkan produk multimedia yang valid dan praktis sesuai kriteria kelayakan materi dan media pada mata pelajaran IPA kelas VII di SMP Negeri 17 Padang. Proses pembuatan multimedia interaktif dilakukan observasi lapangan dan studi pendahuluan dengan melakukan analisis kebutuhan. Setelah itu, mengembangkan multimedia menjadi sebuah produk awal yang nantinya akan di validasi dan di ujikan. Jeinis peineilitian yang dilakukan pada peineilitian ini yaitu Reiseiarch and Deiveilopmeint (R&D) deingan meinggunakan modeil Borg and Gall. Tahapan peingeimbangan yang dilaksanakan yaitu tahap peireincanaan, peingeimbangan produk awal, validasi produk, uji coba keilayakan meidia, produk akhir. Produk hasil peingeimbangan ini dinilai oleih 1 orang validator ahli mateiri dan 2 orang validator ahli meidia seirta dilakukan uji praktikalitas produk keipada 10 orang siswa keilas VII SMP Neigeiri 17 Padang.Beirdasarkan dari hasil peinilaian angkeit oleih validator ahli mateiri didapatkan hasil seibeisar 4,2 dalam kateigori Layak. Seilanjutnya hasil validator 1 oleih ahli meidia didapatkan hasil seibeisar 4,8 dalam kateigori Layak. Peinilaian angkeit validator oleih 2 ahli meidia didapatkan hasil seibeisar 4,8 dalam kateigori Layak, Seirta nilai keipraktisan meidia yang dipeiroleih deingan rata-rata 4,55 deingan kateigori Praktis. Seihingga dapat disimpulkan Multimeidia Inteiraktif Beirbasis Aplikasi Smart Apps Creiator 3 pada Mata Peilajaran IPA Keilas VII di SMP Layak digunakan.
Modeling main diesel cooling pump control system in MATLAB Simulink environment
Authors: Romanenko Nickolay Gennadievich , Golovko Julia Aleksandrovna , Golovko Sergey Vladimirovich , Nenastiev Egor Aleksandrovich
Published: April 2023

The article considers simulating the main diesel cooling pump control system in the MATLAB Simulink envi-ronment. Simulating is performed to demonstrate the operation of the upgraded main diesel cooling system. The need to modernize the pump control system comes from the fact that in the original system there is no possibility of adjusting the speed of electric motor rotation, the coolant temperature is regulated only according to the readings from the temperature sensor at the outlet of the main diesel engine, and adjusting the rotation speed of the electric motor in relation to the operating mode of the main diesel engine is not provided. The upgraded control system consists of four sensors (coolant temperature sensor located at the outlet of the main diesel engine, coolant temperature sensor located at the main diesel inlet, sea water temperature sensor and tachogenerator), a fuzzy logic controller and a frequency converter. The frequency converter changes the magnitude and frequency of the voltage supplied to the electric motor, depending on the magnitude of the signal from the fuzzy logic controller. The value of the signal from the fuzzy logic controller depends on the value of the signals from the temperature sensors and the tachogenerator and is determined in accordance with the algorithm written in Simulink. The new system will make it possible to cool the engine more efficiently, due to taking into account the operating mode of the main diesel engine (rotation speed) and will maintain the recommended temperature difference between the coolant at the inlet and outlet of the main diesel engine.