bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents
Authors: Özdemir Ahmet , Gökbulut Sevtem , Sever Belgin , Çiftçi Gülşen A. , Altıntop Mehlika D.
Published: December 2017

Background:

Arylidene indanones have attracted a great deal of interest due to their outstanding
therapeutic applications. In particular, considerable research has pointed out the importance of arylidene indanones
in the field of cancer research.

Objective:

The aim of the current work was to design and synthesize arylidene indanone-based anticancer agents.

Method:

New arylidene indanones were obtained via the Claisen-Schmidt condensation of 5-chloro-6-methoxy-
2,3-dihydro-1H-inden-1-one with p-substituted benzaldehyde derivatives. MTT assay was performed to evaluate
their cytotoxic effects on MCF-7 human breast adenocarcinoma, HeLa human cervix carcinoma and NIH/3T3
mouse embryonic fibroblast cell lines. The most effective derivatives were evaluated for their DNA synthesis
inhibitory and apoptotic effects. The most apoptotic compounds were also investigated for their effects on
caspase-3 activation in HeLa cells. The binding interactions of the most effective caspase-3 activator at the
active site of caspase-3 were confirmed through molecular docking studies using Schrodinger’s Maestro molecular
modeling package.

Results and Conclusion:

Compounds 2, 3, 4, 5, 6 and 7 exhibited selective anticancer activity against HeLa
cells, whilst compounds 7 and 10 showed selective anticancer activity against MCF-7 cells. Compound 10
caused significant DNA synthesis inhibition on MCF-7 cells, whereas compound 3 caused significant DNA
synthesis inhibition on HeLa cells. Compounds 2 and 3 were determined as the most apoptotic agents against
HeLa cells, whereas compounds 7 and 10 showed apoptotic activity against MCF-7 cells. Besides, compound 2
was identified as the most effective compound on caspase-3 activation in HeLa cells. Docking studies showed
that compound 2 interacted with the residues His121 and Tyr204 forming π-π stacking interactions.
A STUDY OF THE ATTITUDE OF COLLEGE STUDENTS OF PUNJAB TOWARDS YOGA
Authors: Asija Anurag
Published: December 2017

In modern life, people generally try to accomplish too much in too little time, consequently they accumulate a lot of stress in their lives. In that time, yoga plays an important role to alleviate the stress and rejuvenate the body. In the times, yoga was a form of Bhakti. Rishi Patanjali, rightly called the father of yoga, who around 200 b.c. gave us the present literary form of yoga doctrine in his famous treaties Yoga Sutra. In modern times, the value of yoga is being increasingly recognized for general and it’s preventive and curative effects. Yoga does not conceive man having a physical body but on the contrary, it emphasizes the greater values of the mind which characterizes his personality, Thus, yoga leads to ultimate physical health and happiness together with the achieve of mental and patience.
HEAD OF INSTITUTION AND HIS DUTIES
Authors: Dadhwa Sushil Kumar
Published: December 2017

In this article, an attempt has been made to focus on the head of institution and his qualities. The head of the institution is considered the mirror of the institution. It means that if the head of the institution will be qualitative person then his school will also be qualitative in the field of education and other co-curricular activities. Head of the institution should have good qualities because head is model for teachers, students as well as for the members of society. In this article researcher has focused on the head of the institution and his qualities. The researcher have not only hope but also fully faith that this article would be very helpful for those person who are going to become the head of the institution.
Outcomes of a Digitally Delivered Low-Carbohydrate Type 2 Diabetes Self-Management Program: 1-Year Results of a Single-Arm Longitudinal Study (Preprint)
Authors: Saslow Laura R , Summers Charlotte , Aikens James E , Unwin David J
Published: December 2017

BACKGROUND

Type 2 diabetes mellitus has serious health consequences, including blindness, amputation, stroke, and dementia, and its annual global costs are more than US $800 billion. Although typically considered a progressive, nonreversible disease, some researchers and clinicians now argue that type 2 diabetes may be effectively treated with a carbohydrate-reduced diet.

OBJECTIVE

Our objective was to evaluate the 1-year outcomes of the digitally delivered Low-Carb Program, a nutritionally focused, 10-session educational intervention for glycemic control and weight loss for adults with type 2 diabetes. The program reinforces carbohydrate restriction using behavioral techniques including goal setting, peer support, and behavioral self-monitoring.

METHODS

The study used a quasi-experimental research design comprised of an open-label, single-arm, pre-post intervention using a sample of convenience. From adults with type 2 diabetes who had joined the program and had a complete baseline dataset, we randomly selected participants to be followed for 1 year (N=1000; mean age 56.1, SD 15.7 years; 59.30% (593/1000) women; mean glycated hemoglobin A1c (HbA1c) 7.8%, SD 2.1%; mean body weight 89.6 kg, SD 23.1 kg; taking mean 1.2, SD 1.01 diabetes medications).

RESULTS

Of the 1000 study participants, 708 (70.80%) individuals reported outcomes at 12 months, 672 (67.20%) completed at least 40% of the lessons, and 528 (52.80%) completed all lessons of the program. Of the 743 participants with a starting HbA1c at or above the type 2 diabetes threshold of 6.5%, 195 (26.2%) reduced their HbA1c to below the threshold while taking no glucose-lowering medications or just metformin. Of the participants who were taking at least one hypoglycemic medication at baseline, 40.4% (289/714) reduced one or more of these medications. Almost half (46.40%, 464/1000) of all participants lost at least 5% of their body weight. Overall, glycemic control and weight loss improved, especially for participants who completed all 10 modules of the program. For example, participants with elevated baseline HbA1c (≥7.5%) who engaged with all 10 weekly modules reduced their HbA1c from 9.2% to 7.1% (P<.001) and lost an average of 6.9% of their body weight (P<.001).

CONCLUSIONS

Especially for participants who fully engage, an online program that teaches a carbohydrate-reduced diet to adults with type 2 diabetes can be effective for glycemic control, weight loss, and reducing hypoglycemic medications.
Introducing the Power, Conflict, and Democracy Programme
Authors: Törnquist Olle
Published: December 2017

The state of democracy in the Global South is marked by a striking paradox: while liberal democracy has attained an ideologically hegemonic position through two so-called waves of democracy, the qualities of such democracies is increasingly called into question. The "old" democracies in the global South like Sri Lanka are weakened. Democracy deficits have emerged within constitutional and institutional arrangements as well as in political practices. Further, the "third wave of democracy" is over. "New" democracies like Indonesia have fostered freedoms, privatisation and decentralisation but continue to suffer from poor governance, representation, and participation. Hence there are general signs of decline. Vulnerable people are frustrated with lack of actual influence and sustained elitism. Politicians winning elections often need to foster ethnic and religious loyalties, clientelism and the abuse of public resources. Powerful groups and middle classes with poor ability to win elections tend to opt for privatisation and return partially to authoritarian governance.Critical questions are therefore asked about the feasibility of democracy in developing country contexts. Some observers say it is only a problem of better crafting of institutions. Others contend that "full" democratisation was premature in the first place and that necessary preconditions need to be created beforehand. This article argues that both positions are based on a narrow and static understanding of democracy. While the core elements of democracy are universal, real world democracies develop (or decline) over time and through contextual dynamics; in processes and contexts of actors, institutions and relations of power. Therefore, the crucial task is to analyse the problems and options of expanding the historically "early" freedoms and deficient elements of democracy that fortunately exist in spite of poor socio-economic and political conditions in countries such as Sri Lanka and Indonesia rather than giving up on these freedoms until the other conditions have somehow improved. This is to advance towards the universally accepted aim of democracy in terms of popular control of public affairs on the basis of political equality; and to be able to use democracy to handle conflicts and alter unequal and unsustainable development.
State and Civil Society Relationships in Indonesia: A society-oriented Reading in Search for Democratic Space
Authors: Mundayat Aris Arif , Narendra Pitra , Irawanto Budi
Published: December 2017

This paper has shown how the relationship between state and civil society in Indonesia is part of the problem of building democratic government. The problems in Indonesian society is the polycentric nature, by which civil society organisations or popular organisations are being fragmanted and often unorganised. This has made it increasingly difficult to transform various conflicts into more political through democratic institution. At least there are four major problems:The first problem is when a strong civil society faces an ineffective state tactic of governmentality. This tends to stimulate civil society resistance and conflict; or it fosters coexistence through alternative governmentality techniques where the relationship between the state and society is in conflict. The second problem is when a weak civil society faces and effective state. This tends to trigger practices of money politics which are embedded in patronage and clientelism. The third problem can be found in the situation where weak civil society faces an ineffective state which tends to stimulate the emergence of extralegal governmentality practiced by thugs, militia, vigilantes, and paramilitaries. The fourth problem is reflected in the situation where a strong civil society faces an effective state.
Public Opinion on Peace as a Reflection of Social Differentiation and Politicisation of Identity in Sri Lanka
Authors: Stokke Kristian , Peiris Pradeep
Published: December 2017

This article provides a critical analysis of the public opinion on peace in Sri Lanka, with consideration to two determinants: social differentiation and politicisation of identities. Specifically, it aims at developing arguments about the correlations between public opinion, social position, and political mobilisation. Inspired by Bourdieu's concepts of habitus, social space, and political field, this article develops an empirical analysis of the links between ethnic identity and public opinion on peace, and between social differentiation and opinions within the Sinhalese majority community in Sri Lanka. This article argues that ethnic polarisation and politicisation were the foremost determinants of public opinion during the peace process in 2002-2009.
Mainstreaming Radical Politics in Sri Lanka: The case of JVP post-1977
Authors: Dewasiri Nirmal Ranjith
Published: December 2017

This article provides a critical understanding of dynamics behind the roles of the People's Liberation Front (JVP) in post-1977 Sri Lankan politics. Having suffered a severe setback in the early 1970s, the JVP transformed itself into a significant force in electoral politics that eventually brought the United People's Freedom Alliance (UPFA) to power. This article explains the transformation by examining the radical political setting and mapping out the actors and various movements which allowed the JVP to emerge as a dominant player within the hegemonic political mainstream in Sri Lanka. Furthermore, it also highlights the structural changes in JVP politics and its challenges for future consolidation.
The Soft Power of a Small State: Discursive Constructions and Institutional Practices of Norway's Peace Engagement
Authors: Stokke Kristian
Published: December 2017

Since the end of the Cold War, Norway has widely functioned as facilitator for conflict resolution in interstate conflicts and, thus, constructed Norwegian foreign policy as an international peace promoter. This article provides a critical understanding of the discursive construction and institutional practices of Norwegian peace engagement and the effectiveness of the Norwegian approach in conflict resolution experiences. By utilising valuable insights from international relations theories, this article critically analyses the construction of identity and interests in Norwegian foreign policy discourse, focusing particularly on the balancing act between realist and idealist internationalism in peace engagement.
Financing Politics in Indonesia
Authors: Mas'oed Mohtar , Savirani Amalinda
Published: December 2017

This paper aims to map out practices of political financing in Indonesia from the political to the socio-historical perspective. Arguing about the party financing and the corruption of politicians and the parties, this paper also proposes about strategies at the individual level for performing financing politics, as well as factors that help to explain their performance. It compares cases in three different periods of Indonesian history: the post-independence, the Suharto (New Order) era, and reformasi after the fall of Suharto in 1998. This paper discusses and analyses the financing politics belonging to the political and socio-historical perspective, the issue of financing politics, the results of mapping students theses from three universities in Java together with relevant papers by LIPI (the Indonesian Sciences Institute), and directly presents three case studies of individual performing financing politics. Two of the case studies concern with politicians from the post-independence and Suharto era, while the third concerns a member of the city of Solo's local parliament. This paper shows how financing politics would be no longer relevant, as the cultural capital, political capital, and social capital also may contribute in supporting one's political career.
Local Politics in Indonesia, 1999-2010: A Literature Review
Authors: Hanif Hasrul , Pratikno Pratikno
Published: December 2017

This paper attempts to map out the existing literature on the post-1999 political landscape at the local level. This literature review is made up by five key questions: (1) How is localising of power in Indonesia understood?; (2) How does power operate at local levels?; (3) What are the forces that shape Indonesian local politics?; (4) What are the prominent manifestations in Indonesian local politics?; (5) What are alternative political forces that possibly represent the setting up of the street demonstrations?; (6) What is the type of democratic governance format explored in the existing literature?
De muros, fronteras y otros bordes. Notas para una historia crítica del muro como elemento arquitectónico
Authors: Brinkman-Clark William
Published: December 2017

La modernidad explotó la forma y la función de los muros.
Dejaron de mantener fuera a la otredad disfrazada de invasores y bárbaros, y pasaron a contener la otredad al interior de la sociedad, a separar y, con ello, determinar a los locos, los criminales y los enfermos. Las penitenciarías, los hospitales y las cárceles servirían de prototipo para los muros del siglo xx, muros cuyo objetivo era aislar los elementos que amenazan la homogeneidad de una sociedad moderna y civilizada. El muro de Berlín, los de Gaza y de Cisjordania, así como el fronterizo entre nuestros países y, en especial, todos aquellos que recuerda Ortiz y que encierran fraccionamientos y clubes de golf, o que simplemente nos encierran dentro de nuestra propia casa, son el último eslabón de la historia arquitectónica del muro que aquí se propone. La dimensión simbólica de algunos puede ser abordada por medio de la literatura; la de otros, mediante la poesía, el cine, el drama o la televisión; la de unos cuantos más, quizá no cuenta con un medio de fácil acceso. En suma, el trabajo por realizar consistiría en encontrar el significado de cada uno, lo que cada sociedad y época dice sobre sus muros y, por supuesto, lo que los muros nos dicen de las sociedades y las épocas.
La monstruosa cartografía patagónica o los mapas como discursos retóricos
Authors: Gattás Vargas Maia , Gabriela Núñez Paula , Lema Carolina
Published: December 2017

En este artículo se revisan la delimitación y la representación de la región patagónica argentina en diversos mapas. Dicho espacio se incorporó tardíamente al país sudamericano y se caracterizó como frontera en discursos que mezclan la línea y el territorio. Este proceso de apropiación está representado gráficamente en los mapas, lo cual permite evidenciar cómo las fronteras estatales y las de organización interna de Estado se superponen. Así, el mapa se erige en constructor, reproductor y naturalizador de discursos.
Dinamika Keberlangsungan Kelompok Pengusul HKm Sepakat, Pangkalan Bun, Kalimantan Tengah
Authors: Amalia Risna Noviati , Afiff Suraya Abdulwahab
Published: December 2017

This study aims to gain an understanding on a process by which a group can survive. This research applies qualitative and ethnographic methods in the form of case study of one community group in Central Kalimantan that was formed to abtain social forestry permit with Hutan Kemasyarakatan scheme. This study traces internal and external dynamics that contribute significantly to the group’s ability to survive, despite the challenge of this group to gain support from local government. The results show that a number of factors play an important role in maintaining the existence of groups such as the role of the group leader, the motivation and meaning of the group for the members, and how the actors outside the group such as non-governmental organizations and related government agencies concerned with the existence of the group. I hope that the results of this study can improve the understanding of interested parties to support community institutions in forest management. Studi ini bertujuan untuk memperoleh pemahaman tentang proses yang membuat suatu kelompok dapat terus bertahan. Penelitian dengan menggunakan metode kualitatif dan etnografi ini mengangkat studi kasus satu kelompok masyarakat di Kalimantan Tengah yang dibentuk untuk memperoleh ijin perhutanan sosial dengan skema Hutan Kemasyarakatan.Penelitian ini menelusuri dinamika internal dan eksternal yang berkontribusi nyata pada kemampuan kelompok untuk dapat bertahan, terlepas dari kenyataan tantangan kelompok ini untuk memperoleh dukungan dari pemerintah daerah setempat.Hasil penelitian menunjukkan bahwa sejumlah faktor berperan penting untuk mempertahankan keberadaan kelompok seperti peran dari ketua kelompok, motivasi dan makna kelompok bagi anggota, serta bagaimana aktor-aktor di luar kelompok seperti lembaga swadaya masyarakat dan lembaga pemerintah terkait yang berkepentingan dengan keberadaan kelompok.Penulis berharap hasil penelitian ini dapat meningkatkan pemahaman pihak-pihak yang tertarik untuk mendukung kelembagaan masyarakat dalam pengelolaan hutan
Phenolic compounds, antioxidant and antimicrobial properties of the wild cherry (Prunus avium L.) stem
Authors: Ademovic Zahida , Hodzic Snjezana , Halilic-Zahirovic Zarka , Husejnagic Darja , Dzananovic Jasna , Saric-Kundalic Broza , Suljagic Jasmin
Published: December 2017

The aim of this study was to determine the total phenolic content, evaluate
antioxidant propertie and antimicrobial potential, and identify phenolic
compounds in alcoholic and aqueous extracts of the wild cherry (Prunus avium
L.) stems collected in Bosnia and Herzegovina. Alcoholic extracts had higher
contents of phenolic and flavonoid components, as well as the antioxidant and
ferric reducing antioxidant capacity in comparison to aqueous extracts. All
extracts were characterized by HPLC analysis. Furthermore, for the first
time, the antimicrobial properties of wild cherry stem extracts were
evaluated. Quercetin and (+)-catechin were the main compounds identified in
the alcoholic extract, followed by chlorogenic acid and rutin. Quercetin was
also the major component detected in aqueous extracts. Besides, alcoholic
extract showed better antibacterial properties against Staphylococcus aureus
as a representative gram-positive bacteria than infusion, whereas none of the
samples showed antibacterial activity against Escherichia coli and fungus
Candida albicans.
Effect of aluminium particles on mechanical and morphological properties of epoxy nanocomposites
Authors: Bello Sefiu , Agunsoye Johnson , Adebisi Jeleel , Hassan Suleiman
Published: December 2017

Bumper is a front or rear part of automobiles. It is designed and shaped to
be impact absorbing and protecting automobiles from damage in low impact
collisions. Initially, they were made from heavy steels, increasing the
weight of automobiles and fuel consumption. Also, high impacts of steel
bumpers on pedestrians during accidental collision cause fatalities and or
disabilities. An effort to enhance fuel efficiency, safety, freedom of design
and shape detailing, heavy alloys for automobile applications are now being
replaced with polymeric composites. Aluminium micro particles and
nanoparticles were prepared from aluminium cans through sand casting, lathe
machine spinning, and ball milling techniques. Both types of aluminium
particles were incorporated into a mixture of diglycidyl ether of bisphenol A
(DGEBA, epoxy resin) cured with amine base hardener (ABH). Phases of the
epoxy polymer and composites were identified using Xray Diffraction (XRD).
Spatial arrangement of the phases within the matrix and their elemental
composition were examined using Scanning Electron Microscope with attached
energy dispersive X-ray spectroscopy (SEM/EDX). Tensile, impact and micro
hardness tests were conducted on the prepared epoxy/aluminium composites.
Results of the XRD showed the presence of aluminium compounds/phases due to
chemical reactions between aluminium particles and DGEBA/ABH system. SEM
confirmed a homogeneous distribution of the phases within the epoxy matrix,
and that there is a strong adhesion between the epoxy matrix and aluminium
particles. Correlation between the mechanical properties of the prepared
nanocomposite and the procured bumper materials exhibited a fair suitability
of the prepared nanocomposites for automobile applications.
Influence of storage period on properties of biopolymer packaging materials and pouches
Authors: Bulut Sandra , Lazic Vera , Popovic Senka , Hromis Nevena , Suput Danijela
Published: December 2017

Bilayer biodegradable films based on pumpkin oil cake (PuOC) and zein, as
well as pouches made from these materials, were prepared, and the changes of
their mechanical, physicochemical and barrier properties were analyzed during
four weeks of storage. Heat seal quality of formed pouches and composition of
the gas atmosphere in the pouches were also monitored. The results showed
that the bilayer film had a thickness of 300 ? 10 (?m), and no its changes
were observed during the storage time. The tensile strength of the tested
film increased slightly in the third week, but the elongation at break showed
a decreasing trend during the whole storage period. The decreases in the
moisture content, total soluble matter and swelling of the obtained film,
were also observed. After one month of storage, the O2 transmission rate of
tested films, increased from 27 to 64 (ml/m2 24h 1 bar), and the CO2 gas
transmission rate from 147 to 188 (ml/m2 24h 1 bar). The heat seal strength
of the PuOC/Zein pouches decreased during the whole storage period. The
percentage of O2 in PuOC/Zein pouches increased up to 7 times during the
storage period; however, the percentage of CO2 decreased up to 18 times
already after one week, and then remained stable in the rest of the storage
period. These results are, to a smaller extent, due to the gas transmission
rate through the material, especially for CO2 , and to a greater extent, due
to the low heat seal strength, which decreased through the storage period,
and probably influenced the content of the gases in the pouches.
Bioactivity of blackberry (Rubus fruticosus L.) pomace: Polyphenol content, radical scavenging, antimicrobial and antitumor activity
Authors: Cetojevic-Simin Dragana , Ranitovic Aleksandra , Cvetkovic Dragoljub , Markov Sinisa , Vincic Milica , Djilas Sonja
Published: December 2017

A large volume of industrial waste of biological origin is produced annually
worldwide, causing a serious disposal problem even though it is a huge source
of beneficial compounds which may be used for their high nutritional and
bioactive properties. The bio-potential of blackberry pomace (waste) obtained
after juice separation from the Cacanska bestrna and Thornfree cultivars was
evaluated. Higher amounts of total and monomeric anthocyanins, total
phenolics, and total flavonoids were found in Thornfree pomace extract and
demonstrated stronger 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging
activity (2.12 mmol TEAC g-1) than Cacanska bestrna pomace extract (1.03 mmol
TEAC g-1). Both extracts highly increased apoptosis/necrosis ratios in all
investigated cell lines. The highest cell growth inhibition effects
(EC50=52.5 - 64.7 ?g mL-1) and the highest increase of apoptosis (AI=12.2)
were obtained in breast adenocarcinoma cell line. Both blackberry pomace
extracts inhibited the growth of all tested microorganisms. In the reference
and wild bacterial strains MIC and MBC/MFC were achieved in the 0.39-25 mg
mL-1 and 0.78-25 mg mL-1 range, respectively. Blackberry cultivar pomaces are
rich source of phytochemicals with significant health promoting properties
that could be further utilized as beneficial food ingredients.
Changes in milk composition of domestic Balkan donkeys’ breed during lactation periods
Authors: Lazarevic Jasmina , Tasic Tatjana , Popovic Sanja , Banjac Vojislav , Djuragic Olivera , Kokic Bojana , Cabarkapa Ivana
Published: December 2017

Changes in the milk composition during early, middle and late stage of
lactation period were monitored in 10 individual autochthonous donkeys of the
Domestic Balkan breed. Animals were grazing ad libitum during early and
middle lactation, while supplements (meadow hay, corn and corn stalks) were
added during the late lactation period. The aim of this study was to evaluate
the main compounds of donkeys? milk during different periods of lactation.
Based on the obtained results it was noticed that nutritional effects on milk
composition were the greatest in the early and middle lactation. Chemical
analysis indicated that donkeys? milk was quite poor in dry matter
(8.82-9.68%), fat (0.54-0.67%) and protein (1.44-1.79%), and conversely was
high in lactose content (6.06-7.12%). Concentration of vitamin C varied
significantly (P<0.05) during the lactation period and was very high
(12.84-26.89 ?g/mL) in comparison to milk from other animal species.
Likewise, the content of lysozyme (1.95-3.29 g/L) and lactoferrin (1.56-3.14
g/L) during the early and middle lactation period showed an increase.
Donkeys' milk did not show any significant differences in MUFA, n6-PUFA and
UFA contents, while n3-PUFA, n6/n3 and UFA/SFA ratio showed a significant
variability (P<0.05) during the lactation period.
Chromatographic lipophilicity and pharmacokinetic behavior of some newly synthesized styryl lactone stereoisomers
Authors: Lоncаr Dаvоr , Мilоsеvic Nаtаsа , Vitas Jasmina , Karadzic Milica , Jevric Lidija , Benedekovic Goran
Published: December 2017

The RP-HPLC retention constants of several newly synthesized cytotoxic styryl
lactone stereoisomers were determined as parameters of their lipophilicity.
Stereochemistry of the compounds has an effect on the retention behavior of
only tricyclic isomers. For them, the difference in retention and
chromatographic lipophilic parameters are significant. The chromatographic
lipophilic parameters of all compounds were correlated with a fourteen
computer calculated lipophilic parameters, log P, and pharmacokinetic
parameters. Significant linear correlations (R2 adj>0.90) were obtained
between MLog P and affinity for plasma proteins binding. The correrelations
for the other pharmacokinetic parameters were improved by introducing some
more molecular descriptors. Multiple linear regression analysis suggested
that the volume of distribution depended on the lipopholicity and Ka HSA
(HSA-human serum albumin) and the absorption through membrane and
permeability in the jejunum depend on the lipophilicity and hydrogen bond
donors. The tested compounds showed a potent to moderate cytotoxic activity
toward several human cancer cells and poor permeation through the blood brain
barrier.
Extraction and encapuslation of bioactive compounds from carrots
Authors: Seregelj Vanja , Cetkovic Gordana , Canadanovic-Brunet Jasna , Tumbas-Saponjac Vesna , Vulic Jelena , Stajcic Sladjana
Published: December 2017

Carrot is an important root vegetable rich in bioactive compounds like
carotenoids and polyphenols with appreciable levels of several other
functional components having significant health-promoting properties.
Utilization of carotenoids is limited due to their instability. Encapsulation
is one of the alternatives used to improve carotenoid stability. The
objectives of this study were to optimize the extraction and encapsulation of
carotenoids from carrot. Freeze-dried carrots were extracted by conventional
solvent extraction (CSE) using four solvents, i.e. ethanol, acetone, ethyl
acetate, and hexane. Although CSE using hexane and ethyl acetate resulted in
highest carotenoid contents (18.27 and 15.73 mg ?-carotene/100 g), acetone
and ethanol at a solid to solvent ratio 1:10 w/v with slightly lower
carotenoid contents (14.52 and 11.45 mg ?-carotene/100 g) were chosen for
further studies due to their higher food compatibility and higher polyphenol
content (88.86 and 66.21 mg GAE/100 g) than with lower solid to solvent ratio
(1:5 w/v). Ethanol and acetone carrot extracts were encapsulated using
different carriers by a freeze-drying method in order to obtain the optimum
encapsulate with the highest carotenoid encapsulation efficiency (EE).
Encapsulation using the maltodextrin, whey and soy protein as a wall material
yielded an EE of carotenoids ranging from 41.95% to 100%. The encapsulated
?-carotene content was evaluated during two months of storage at ambient
temperature under light and dark conditions. Generally, the retention of
carotenoids was significantly higher in dark conditions, where maximum
retention (65.94-87.32%) occurred in the samples encapsulated in maltodextrin
and soy protein.
Flux intensification during microfiltration of distillery stillage using a kenics static mixer
Authors: Vasic Vesna , Jokic Aleksandar , Sciban Marina , Prodanovic Jelena , Dodic Jelena , Kukic Dragana
Published: December 2017

The present work studies the effect of operating parameters (pH, feed flow
rate, and transmembrane pressure) on microfiltration of distillery stillage.
Experiments were conducted in the presence of a Kenics static mixer as a
turbulence promoter, and its influence on the flux improvement and specific
energy consumption was examined. Response surface methodology was used to
investigate the effect of selected factors on microfiltration performances.
The results showed that response surface methodology is an appropriate model
for mathematical presentation of the process. It was found that the use of a
static mixer is justified at the feed flow rates higher than 100 L/h. In
contrast, the use of a static mixer at low values of feed flow rate and
transmembrane pressure has no justification from an economic point of view.
Determination of culture medium composition for maximizing the biomass production of Pseudomonas stutzeri
Authors: Vidakovic Ana , Sovljanski Olja , Ranitovic Aleksandra , Cvetkovic Dragoljub , Markov Sinisa
Published: December 2017

In the recent years, extensive studies have been conducted on the application
of bioremediation in order to prevent and solve the global problem of nitrate
accumulation especially in water and soil. In the studies related to the
biological denitrification, Pseduomonas stutzeri is usually used as a model
microorganism due to its ability of performing a complete reduction of
nitrate. The aim of this work is to establish a culture medium at a
laboratory level for maximizing the biomass production of Pseduomonas
stutzeri ATCC 17588 and Pseudomonas stutzeri D1, previously isolated from the
Danube (Novi Sad, Serbia) by using a Box-Bhenken experimental design and
response surface methodology. The selected independent variables (+, 0, -
levels) were: glucose (0, 1 and 2 g/L), KNO3 (1, 2 and 3 g/L), and peptone
(0.4, 2 and 4 g/L), while the number of viable cells (log/mL) was chosen as a
dependent factor (response). Based on the obtained results, it can be noticed
that the maximum number of P. stutzeri ATCC 17588 viable cells is achieved
when the initial content of glucose, KNO3 and peptone in the medium are 0
g/L, 2 g/L and 4 g/L, respectively. In the case of P. stutzeri D1, the most
appropriate media for enhancing the biomass production consists of glucose (1
g/L), KNO3 (3 g/L) and peptone (4 g/L). ?he obtained results can be used for
further technoeconomic analysis and scale up of the P. stutzeri biomass
production.
Research in Social Media: Data Sources and Methodologies
Authors: Debreceny Roger S. , Wang Tawei , Zhou Mi (Jamie)
Published: December 2017

This paper examines both the opportunities and limitations in the use of social media for accounting research. Given the dynamic nature of social media and the richness of the context, there are opportunities for researchers to directly observe communication and information exchanges, typically within the context of an observable social network. The paper provides an overview of the characteristics of four commonly used social network sites (SNSs): Facebook, Twitter, LinkedIn, and StockTwits. The data collection details, opportunities, and limitations are set out. The paper also provides illustrative examples of codes that a researcher might employ to extract information from the SNSs. To provide a comparison of accounting-relevant interactions, the paper measures the extent of posts on StockTwits, Twitter, and Facebook for a random sample of corporate announcements.
The Synthetic Microneurotrophin BNN27 Affects Retinal Function in Rats With Streptozotocin-Induced Diabetes
Authors: Ibán-Arias Ruth , Lisa Silvia , Mastrodimou Niki , Kokona Despina , Koulakis Emmanuil , Iordanidou Panagiota , Kouvarakis Antonis , Fothiadaki Myrto , Papadogkonaki Sofia , Sotiriou Aggeliki , Katerinopoulos Haralambos E. , Gravanis Achille , Charalampopoulos Ioannis , Thermos Kyriaki
Published: December 2017

BNN27, a C17-spiroepoxy derivative of DHEA, was shown to have antiapoptotic properties via mechanisms involving the nerve growth factor receptors (tropomyosin-related kinase A [TrkA]/neurotrophin receptor p75 [p75NTR]). In this study, we examined the effects of BNN27 on neural/glial cell function, apoptosis, and inflammation in the experimental rat streptozotocin (STZ) model of diabetic retinopathy (DR). The ability of BNN27 to activate the TrkA receptor and regulate p75NTR expression was investigated. BNN27 (2,10, and 50 mg/kg i.p. for 7 days) administration 4 weeks post–STZ injection (paradigm A) reversed the diabetes-induced glial activation and loss of function of amacrine cells (brain nitric oxide synthetase/tyrosine hydroxylase expression) and ganglion cell axons via a TrkA receptor (TrkAR)-dependent mechanism. BNN27 activated/phosphorylated the TrkAY490 residue in the absence but not the presence of TrkAR inhibitor and abolished the diabetes-induced increase in p75NTR expression. However, it had no effect on retinal cell death (TUNEL+ cells). A similar result was observed when BNN27 (10 mg/kg i.p.) was administered at the onset of diabetes, every other day for 4 weeks (paradigm B). However, BNN27 decreased the activation of caspase-3 in both paradigms. Finally, BNN27 reduced the proinflammatory (TNFα and IL-1β) and increased the anti-inflammatory (IL-10 and IL-4) cytokine levels. These findings suggest that BNN27 has the pharmacological profile of a therapeutic for DR, since it targets both the neurodegenerative and inflammatory components of the disease.
In Vivo Visualization of β-Cells by Targeting of GPR44
Authors: Eriksson Olof , Johnström Peter , Cselenyi Zsolt , Jahan Mahabuba , Selvaraju Ram K. , Jensen-Waern Marianne , Takano Akihiro , Sörhede Winzell Maria , Halldin Christer , Skrtic Stanko , Korsgren Olle
Published: December 2017

GPR44 expression has recently been described as highly β-cell selective in the human pancreas and constitutes a tentative surrogate imaging biomarker in diabetes. A radiolabeled small-molecule GPR44 antagonist, [11C]AZ12204657, was evaluated for visualization of β-cells in pigs and nonhuman primates by positron emission tomography as well as in immunodeficient mice transplanted with human islets under the kidney capsule. In vitro autoradiography of human and animal pancreatic sections from subjects without and with diabetes, in combination with insulin staining, was performed to assess β-cell selectivity of the radiotracer. Proof of principle of in vivo targeting of human islets by [11C]AZ12204657 was shown in the immunodeficient mouse transplantation model. Furthermore, [11C]AZ12204657 bound by a GPR44-mediated mechanism in pancreatic sections from humans and pigs without diabetes, but not those with diabetes. In vivo [11C]AZ12204657 bound specifically to GPR44 in pancreas and spleen and could be competed away dose-dependently in nondiabetic pigs and nonhuman primates. [11C]AZ12204657 is a first-in-class surrogate imaging biomarker for pancreatic β-cells by targeting the protein GPR44.
CO02 - História da Astronomia em produções do mestrado profissional em ensino de física
Authors: Soares Fabiana Gozze , Oliveira Michele Silva , Da Silva Agenor Pina , Figueiredo Filho Newton
Published: December 2017

RESUMO - COMUNICAÇÃO ORAL
CO06 - A história das ciências colaborando no estudo da estrutura atômica e dos modelos atômicos no ensino médio
Authors: Trancoso Marcelo Delena , Dos Santos Nadja Paraense
Published: December 2017

RESUMO - COMUNICAÇÃO ORAL
RC03 - A ciência nos perfumes: atribuindo significados à química orgânica através da história da temática
Authors: Coelho Márcia Maria Pinto , Moreira Marlon Duarte , Afonso Andreia Francisco
Published: December 2017

RESUMO - RODA DE CONVERSA
RC05 - Hipátia de Alexandria: a presença da mulher no alvorecer das ciências
Authors: Batista Patrícia Da Silva , Quirino Maria José Da Silva de Oliveira , Russo Ana Lúcia Rodrigues Gama , Corrêa Carlos José Galvão
Published: December 2017

RESUMO - RODA DE CONVERSA
P06 - Monumentos históricos: um lugar para o pensamento matemático
Authors: Dos Santos Edson Júnio , Barrére Eduardo
Published: December 2017

RESUMO - PÔSTER
P07 - Encontro Caravana da Ciência: incentivo à prática de Iniciação Científica no Ensino Médio como meio de Ensino e Aprendizagem de Ciências e Divulgação Científica
Authors: Santos Elias De Barros , Roque Zuleika Stefânia Sabino
Published: December 2017

RESUMO - PÔSTER
Commodity Market Heterogeneity and Cross-Market Integration
Authors: Kunkler Michael
Published: December 2017

We evaluate the recent levels of heterogeneity and cross-market integration for fluctuations in commodity futures returns for a post-financial-crisis data sample. We find that a single commodity-market risk factor explains 30.6% of the total variation in commodity futures returns. The commodity-market risk factor is significantly correlated with the dominant market-wide risk factors from other asset classes: +66.7% with a market risk factor for the US equity market; -74.2% with a US dollar risk factor for the FX market; and -27.8% with an interest-rate level risk factor for the US interest rate market. Thus, a part of the systematic variation in the commodity market is integrated with other asset classes.
Criminal arbitration in the Saudi system Tasilah study
Authors: Farouk Abbas Nehad
Published: December 2017

Arbitration is generally an old idea, appear in our time in several kindsof them civil arbitration is the first to appear, and trade which is recognized by the several official forms and taking Msmyate in arbitration centers, whether local, regional or international, and arbitration managing a modern areas, and keeps talking about Criminal arbitration, a field of push and pull in his presence, and legitimacy, and it was our interest in the subject, because the criminal sphere of thorny areas that do not gain from the writer wrote an important purpose, and whatever thousand is fertile ground and appointed inexhaustible. As criminal Arbitration many imperatives that require his presence, and the text it systems, and work by applying the rules of legitimacy to the necessities of the conduct of life among the people easily, cooperation and reconciliation, in particular, that the scope and resources mentioned in numerous surgeries and Alerosh is estimated religiously as will be described in the study, most notably the false mentioning al-Hakim And the importance of the recent subject of arbitration in the criminal field, and touches important aspects of life, and what it requires from the application of the provisions and principles of justice, and its importance in reducing the burden on the modern judiciary, I wanted to contribute interested in the topic in the study of the scarcity of studies that have raised the subject.
Patterns of sleep disorders in children with autism with the attention deficit -hyperactivity disorder
Authors: Fattah Mohammed Hussein Ahmed Abdel
Published: December 2017

The present study aims to identify the extent of the prevalence of some sleep disorders patterns of autistic children with attention deficit hyperactivity disorder, and the preparation and rationing measure of attention deficit hyperactivity disorder when autistic children, and scale disturbances of sleep when autistic children with attention deficit hyperactivity disorder, and differences gender (male - female) in sleep disorders patterns in these children, and to identify the predictable patterns of sleep disorders in autistic children with attention deficit hyperactivity disorder, the study sample: The sample consisted reconnaissance of the (study 60) of children with autism parents, has been application on (60) of children (40 males and 20 females) between the ages of (7 -12 years), sample basic study consisted of (80) of children with autism parents, it has been the application on (80) of autistic children (50 males 0.30 females) between the ages of (7-12 years), and the study sample of visitors to Al Amal Hospital for Mental Health Barar- northern border region - Saudi Arabia, approach the study: the use of a researcher in the current study, the descriptive approach comparative The study found that it can predictable patterns of sleep disorders in children with autism, attention deficit hyperactivity disorder, as some common patterns of sleep disorders in children study sample and found statistically significant differences in sleep disorders among both male and female patterns of children study sample in favor of males.
Arabic Language Sciences, Literature and Arts in Al- Maghreb and Al-Andalus through Ibn Khaldun’s “Muqaddema”
Authors: Qobbaj Amer A.
Published: December 2017

This study aims to identify and portray the main historical and civilizational features of the linguistic situation in Al-Maghreb and Al-Andalus, based on the Muqaddema of Ibn Khaldun (d. 808 A.H\1406 A.D), who was a witness to many of the scientific aspects of civilization in both countries, especially the Arabic language sciences, literature and arts, a large bulk of which, was transferred from the Islamic East and reached Al-Andalus and Al- Maghreb. Ibn Khaldun had divided sciences into two groups: sciences based on textual evidence and sciences based on cognitive reasoning. He considered the Arabic Language sciences within the textual sciences, linking their emergence and wide spread to two reasons: “Umran” (urbanism, culture and civilization), and continuity in the transmission of knowledge from one generation to another in major cities, especially before the destruction of Kairouan by Hilali tribes during the fifth century A.H./eleventh century AD, and before the fall of Cordoba by Spaniards during the seventh A.H century/thirteenth A.D century. Despite the fact that Ibn Khaldoun was pessimistic about the condition of learning and knowledge in his era, particularly the deteriorating condition of the Arabic language caused by the mixing of Arabs with non-Arabs, he mentioned in Muqaddimah many scholars who maintained and protected the Arabic language and spread it in Al-Maghreb and Al-Andalus through their published books in various areas of Arabic syntax, linguistics, semantics, and poetry. These books constituted and shaped the cultural, educational and Islamic identity. Much research has been done in the area of Arabic linguistics, mainly in Al-Maghreb and Al-Andalus, yet most of it did not analyze the contents of the Muqaddema which relate to Arabic language in these two areas. This study investigates the linguistic references in the Muqaddema about the Arabic language and shed some light on the features of the historical relationships between these two regions of the Western Islamic world, as well as the mutual interaction that accompanied the linguistic development there.
TEKNO-CULTURE: MEMAHAMI KONDISI MASYARAKAT MASA DEPAN
Authors: Aswan Aswan
Published: December 2017

The development of advanced communications technology has brought about fundamental changes in the world of life. A number of views on the spirit behind the progress are emerging, as well as about the effects it incurs. This paper tries to see two basic things. First about the passion and trends behind the advances in communication technology. This section includes all-free behavior that encourages the tendency of abnormalities, identity greed, the speed and interconnectedness. Second, about the spirit of thought that underlies the advancement of communication technology. This section reviews the three currents of thought that become the dominant discusus in viewing technology. That thought is; 1) utopianism as an optimistic view of the positive role of science and technology, 2) dystopianism, as a pessimistic view of science and technology, and 3) hypertopianism, as the 'fatalist' view of science and technology. The various streams of thought that the author studied from a number of literatures in this field show the tendency of many thinkers to highlight the negative aspects of the latest advances in communication technology. Similarly depicted in this paper, the gloomy portrayal of the future of communication technology in this paper can be viewed positively, that it gives us a map of the spirit of progress, as a "long-warning system" that provides mapping, and the possibility of the future by departing from current social, cultural and technological trends can help us read its constellations and impacts