bluuebunny/crossref_metadata_2025 huggingface dataset:
Cracking the Initiation Mechanism of High Cu-Bearing Nitrogen-Alloyed Austenitic Stainless Steel in the Process of Hot Deformation
Authors: Fu Xiao-Yang , Bai Pu-Cun , Yang Ji-Chun
Published: October 2018

The cracking initiation mechanism of high Cu-bearing nitrogen-alloyed austenitic stainless steel was systematically investigated by using a Gleeble-1500D simulator under different strains and deformation temperatures in the hot deformation process. The cracking initiation process and microstructure variations were characterized by optical microscopy (OM), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) with energy dispersive spectroscopy (EDS) and transmission electron microscopy (TEM). In the deformation process, Cu-rich and Cr-rich phases were found around the microscopic crack at the strain of 0.5. Cu content was found to be higher at the grain boundary than inside the grain. The equilibrium phase diagram calculated by Thermo-calc shows that Cu precipitates out in the form of an elementary substance below 1022 °C, when the Cu mass fraction reaches 5%. Meanwhile, dislocation walls and twin crystals were observed by TEM. The results show that the synergistic effect of the secondary phases, such as M23C6 precipitated along the grain boundary and stress concentration, lead to crack generation, which is lower at high temperature and low temperature and is higher at 1100 °C and increase as the strain increases.
Design Optimisation of the Feeding System of a Novel Counter-Gravity Casting Process
Authors: Papanikolaou Michail , Pagone Emanuele , Georgarakis Konstantinos , Rogers Keith , Jolly Mark , Salonitis Konstantinos
Published: October 2018

The appropriate design of feeders in a rigging system is critical for ensuring efficient compensation for solidification shrinkage, thus eliminating (shrinkage-related) porosity and contributing to the production of superior quality castings. In this study, a multi-objective optimisation framework combined with Computational Fluid Dynamics (CFD) simulations has been introduced to investigate the effect of the feeders’ geometry on shrinkage porosity aiming to optimise casting quality and yield for a novel counter-gravity casting process (CRIMSON). The weighted sum technique was employed to convert this multi-objective optimisation problem to a single objective one. Moreover, an evolutionary multi-objective optimisation algorithm (NSGA-II) has been applied to estimate the trade-off between the objective functions and support decision makers on selecting the optimum solution based on the desired properties of the final casting product and the process characteristics. This study is one of the first attempts to combine CFD simulations with multi-objective optimisation techniques in counter-gravity casting. The obtained results indicate the benefits of applying multi-objective optimisation techniques to casting processes.
Steric Effect of Antioxidant Diels-Alder-Type Adducts: A Comparison of Sanggenon C with Sanggenon D
Authors: Li Xican , Ren Zhenxing , Wu Zimei , Fu Zhen , Xie Hong , Deng Langyu , Jiang Xiaohua , Chen Dongfeng
Published: October 2018

Sanggenons C and D are two Diels-Alder-type adducts from Chinese crude drug Sang-bai-pi. Structurally, both sanggenons construct stereoisomers. In the study, they were comparatively determined using four antioxidant assays, including ferric ion reducing antioxidant power (FRAP) assay, Cu2+-reducing assay, 1,1-diphenyl-2-picryl-hydrazl (DPPH•)-scavenging assay, and 2,2′-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid radical (ABTS•+)-scavenging assay. Their Fe2+-binding reactions were explored using UV-Vis spectra. Finally, their cytoprotective effects were evaluated using flow cytometry. In electron transfer (ET)-based FRAP and Cu2+-reducing assays, sanggenon D was found to have lower IC50 values than sanggenon C; however, in multi-pathway-based DPPH•-scavenging and ABTS•+-scavenging assays, sanggenon C possessed lower IC50 values than sanggenon D. UV-Vis spectra suggested that sanggenon C generated a bathochromic-shift (286 nm → 302 nm) and displayed stronger UV absorption than sanggenon D. In flow cytometry, sanggenon C and sanggenon D, respectively, exhibited 31.1% and 42.0% early apoptosis-percentages towards oxidative-stressed mesenchymal stem cells (MSCs). In conclusion, both sanggenons may undergo multiple pathways (e.g., ET and Fe2+-binding) to protect MSCs against oxidative stress. In the mere ET aspect, sanggenon D possesses a higher level than sanggenon C, while in multi-pathway-based radical-scavenging, Fe2+-binding, and cytoprotection aspects, sanggenon C is more active than sanggenon D. These discrepancies can conclusively be attributed to the steric effect.
Biodegradation of 7-Hydroxycoumarin in Pseudomonas mandelii 7HK4 via ipso-Hydroxylation of 3-(2,4-Dihydroxyphenyl)-propionic Acid
Authors: Krikštaponis Arūnas , Meškys Rolandas
Published: October 2018

A gene cluster, denoted as hcdABC, required for the degradation of 3-(2,4-dihydroxyphenyl)-propionic acid has been cloned from 7-hydroxycoumarin-degrading Pseudomonas mandelii 7HK4 (DSM 107615), and sequenced. Bioinformatic analysis shows that the operon hcdABC encodes a flavin-binding hydroxylase (HcdA), an extradiol dioxygenase (HcdB), and a putative hydroxymuconic semialdehyde hydrolase (HcdC). The analysis of the recombinant HcdA activity in vitro confirms that this enzyme belongs to the group of ipso-hydroxylases. The activity of the proteins HcdB and HcdC has been analyzed by using recombinant Escherichia coli cells. Identification of intermediate metabolites allowed us to confirm the predicted enzyme functions and to reconstruct the catabolic pathway of 3-(2,4-dihydroxyphenyl)-propionic acid. HcdA catalyzes the conversion of 3-(2,4-dihydroxyphenyl)-propionic acid to 3-(2,3,5-trihydroxyphenyl)-propionic acid through an ipso-hydroxylation followed by an internal (1,2-C,C)-shift of the alkyl moiety. Then, in the presence of HcdB, a subsequent oxidative meta-cleavage of the aromatic ring occurs, resulting in the corresponding linear product (2E,4E)-2,4-dihydroxy-6-oxonona-2,4-dienedioic acid. Here, we describe a Pseudomonas mandelii strain 7HK4 capable of degrading 7-hydroxycoumarin via 3-(2,4-dihydroxyphenyl)-propionic acid pathway.
Lichen Xanthones as Models for New Antifungal Agents
Authors: Resende Diana I. S. P. , Pereira-Terra Patrícia , Inácio Ângela S. , Costa Paulo Martins da , Pinto Eugénia , Sousa Emília , Pinto Madalena M. M.
Published: October 2018

Due to the emergence of multidrug-resistant pathogenic microorganisms, the search for new antimicrobial compounds plays an important role in current medicinal chemistry research. Inspired by lichen antimicrobial xanthones, a series of novel chlorinated xanthones was prepared using five chlorination methods (Methods A–E) to obtain different patterns of substitution in the xanthone scaffold. All the synthesized compounds were evaluated for their antimicrobial activity. Among them, 3-chloro-4,6-dimethoxy-1-methyl-9H-xanthen-9-one 15 showed promising antibacterial activity against E. faecalis (ATCC 29212 and 29213) and S. aureus ATCC 29213. 2,7-Dichloro-3,4,6-trimethoxy-1-methyl-9H-xanthen-9-one 18 revealed a potent fungistatic and fungicidal activity against dermatophytes clinical strains (T. rubrum, M. canis, and E. floccosum (MIC = 4–8 µg/mL)). Moreover, when evaluated for its synergistic effect for T. rubrum, compound 18 exhibited synergy with fluconazole (ΣFIC = 0.289). These results disclosed new hit xanthones for both antibacterial and antifungal activity.
Biodetoxification of Phenolic Inhibitors from Lignocellulose Pretreatment using Kurthia huakuii LAM0618T and Subsequent Lactic Acid Fermentation
Authors: Xie Yuejiao , Hu Qing , Feng Guodong , Jiang Xu , Hu Jinlong , He Mingxiong , Hu Guoquan , Zhao Shumiao , Liang Yunxiang , Ruan Zhiyong , Peng Nan
Published: October 2018

Phenolic inhibitors generated during alkaline pretreatment of lignocellulosic biomasses significantly hinder bacterial growth and subsequent biofuel and biochemical production. Water rinsing is an efficient method for removing these compounds. Nevertheless, this method often generates a great amount of wastewater, and leads to the loss of solid fiber particles and fermentable sugars. Kurthia huakuii LAM0618T, a recently identified microorganism, was herein shown to be able to efficiently transform phenolic compounds (syringaldehyde, hydroxybenzaldehyde, and vanillin) into less toxic acids. Taking advantage of these properties, a biodetoxification method was established by inoculating K. huakuii LAM0618T into the NH3/H2O2-pretreated unwashed corn stover to degrade phenolic inhibitors and weak acids generated during the pretreatment. Subsequently, 33.47 and 17.91 g/L lactic acid was produced by Bacillus coagulans LA204 at 50 °C through simultaneous saccharification and fermentation (SSF) from 8% (w/w) of NH3/H2O2-pretreated corn stover with or without K. huakuii LAM0618T-biodetoxification, indicating biodetoxification significantly increased lactic acid titer and yield. Importantly, using 15% (w/w) of the NH3/H2O2-pretreated K. huakuii LAM0618T-biodetoxified corn stover as a substrate through fed-batch simultaneous saccharification and fermentation, high titer and high yield of lactic acid (84.49 g/L and 0.56 g/g corn stover, respectively, with a productivity of 0.88 g/L/h) were produced by Bacillus coagulans LA204. Therefore, this study reported the first study on biodetoxification of alkaline-pretreated lignocellulosic material, and this biodetoxification method could replace water rinsing for removal of phenolic inhibitors and applied in biofuel and biochemical production using the alkaline-pretreated lignocellulosic bioresources.
Copper Oxide Nanoparticles Cause a Dose-Dependent Toxicity via Inducing Reactive Oxygen Species in Drosophila
Authors: Baeg Eugene , Sooklert Kanidta , Sereemaspun Amornpun
Published: October 2018

Copper oxide nanoparticles (CuONPs) have attracted considerable attention, because of their biocide potential and capability for optical imaging, however CuONPs were shown to be highly toxic in various experimental model systems. In this study, mechanism underlying CuONP-induced toxicity was investigated using Drosophila as an in vivo model. Upon oral route of administration, CuONPs accumulated in the body, and caused a dose-dependent decrease in egg-to-adult survivorship and a delay in development. In particular, transmission electron microscopy analysis revealed CuONPs were detected inside the intestinal epithelial cells and lumen. A drastic increase in apoptosis and reactive oxygen species was also observed in the gut exposed to CuONPs. Importantly, we found that inhibition of the transcription factor Nrf2 further enhances the toxicity caused by CuONPs. These observations suggest that CuONPs disrupt the gut homeostasis and that oxidative stress serves as one of the primary causes of CuONP-induced toxicity in Drosophila.
Screening and Management of Gestational Diabetes Mellitus after Bariatric Surgery
Authors: Benhalima Katrien , Minschart Caro , Ceulemans Dries , Bogaerts Annick , Van Der Schueren Bart , Mathieu Chantal , Devlieger Roland
Published: October 2018

Gestational diabetes mellitus (GDM) is a frequent medical complication during pregnancy. This is partly due to the increasing prevalence of obesity in women of childbearing age. Since bariatric surgery is currently the most successful way to achieve maintained weight loss, increasing numbers of obese women of childbearing age receive bariatric surgery. Bariatric surgery performed before pregnancy significantly reduces the risk to develop GDM but the risk is generally still higher compared to normal weight pregnant women. Women after bariatric surgery therefore still require screening for GDM. However, screening for GDM is challenging in pregnant women after bariatric surgery. The standard screening tests such as an oral glucose tolerance test are often not well tolerated and wide variations in glucose excursions make the diagnosis difficult. Capillary blood glucose measurements may currently be the most acceptable alternative for screening in pregnancy after bariatric surgery. In addition, pregnant women after bariatric surgery have an increased risk for small neonates and need careful nutritional and foetal monitoring. In this review, we address the risk to develop GDM after bariatric surgery, the challenges to screen for GDM and the management of women with GDM after bariatric surgery.
Effects of Glycine on Collagen, PDGF, and EGF Expression in Model of Oral Mucositis
Authors: Sá Odara Maria de Sousa , Lopes Nilza Nelly Fontana , Alves Maria Teresa Seixas , Caran Eliana Maria Monteiro
Published: October 2018

Oral mucositis is frequently a toxic effect of chemotherapeutic and/or radiotherapeutic treatment, resulting from complex multifaceted biological events involving DNA damage. The clinical manifestations have a negative impact on the life quality of cancer patients. Preventive measures and curative treatment of mucositis are still not well established. The glycine has anti-inflammatory, immunomodulatory, and cytoprotective actions, being a potential therapeutic in mucositis. The objective was to evaluate the effects of glycine on the expression of collagen and growth factors, platelet and epidermal in a hamster model oral mucositis. The mucositis was induced by the protocol of Sonis. There were 40 hamsters used, divided into two groups: Group I-control; Group II-supplemented with 5% intraperitoneal glycine, 2.0 mg/g diluted in hepes. Histopathological sections were used to perform the immune-histochemical method, the evaluation of collagen expression, and the growth factors: Epidermal growth factor (EGF) and platelet (PDGF). It was observed that the group supplemented with glycine experienced higher amounts of collagen expression and predominance type of collagen I. The glycine group presented lower immunoexpression of the growth factors, EGF and PDGF. The group supplemented with glycine showed a marked healing process of the oral mucosite, demonstrated by the predominance of collagen type I and reduction of growth factors, EGF and PDGF.
Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA)
Authors: Malkawi Ruba , Iyer Abhishek , Parmar Anish , Lloyd Daniel G. , Leng Goh Eunice Tze , Taylor Edward J. , Sarmad Sarir , Madder Annemieke , Lakshminarayanan Rajamani , Singh Ishwar
Published: October 2018

Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance. In this work, we describe the design and rapid synthesis of novel teixobactin analogues containing two cysteine moieties, and the corresponding disulfide-bridged cyclic analogues. These analogues differ from previously reported analogues, such as an Arg10-teixobactin, in terms of their macrocyclic ring size, and feature a disulfide bridge instead of an ester linkage. The new teixobactin analogues were screened against Methicillin-resistant Staphylococcus aureus and Methicillin-sensitive Staphylococcus aureus. Interestingly, one teixobactin analogue containing all l-amino acid building blocks showed antibacterial activity against MRSA for the first time. Our data indicates that macrocyclisation of teixobactin analogues with disulfide bridging is important for improved antibacterial activity. In our work, we have demonstrated the unprecedented use of a disulfide bridge in constructing the macrocyclic ring of teixobactin analogues.
Establishing a New Ambulatory Care Practice Site as a Pharmacy Practice Faculty
Authors: Gupta Vasudha , Williams Evan
Published: October 2018

There is an imminent need to identify and develop new ambulatory care practice sites with the increase in the number of colleges of pharmacy across the nation. This manuscript provides recommendations to help clinical faculty determine whether a potential pharmacy practice site will be able to provide adequate resources and support to establish a successful practice. This may be challenging to pharmacy practice faculty in settings where clinical pharmacy services have never been utilized. Topics include the pre-work needed prior to approaching a new practice site, assessing the need for physical requirements, meeting key personnel, marketing clinical skills and services, implementing, and evaluating practice site. Preparation includes having a clear vision of the pharmacist services, ensuring that stakeholders have an understanding of the pharmacy services inquiring the site support and resources for the pharmacist, and regularly communicating.
Chromatin Loop Extrusion and Chromatin Unknotting
Authors: Racko Dusan , Benedetti Fabrizio , Goundaroulis Dimos , Stasiak Andrzej
Published: October 2018

It has been a puzzle how decondensed interphase chromosomes remain essentially unknotted. The natural expectation is that in the presence of type II DNA topoisomerases that permit passages of double-stranded DNA regions through each other, all chromosomes should reach the state of topological equilibrium. The topological equilibrium in highly crowded interphase chromosomes forming chromosome territories would result in formation of highly knotted chromatin fibres. However, Chromosome Conformation Capture (3C) methods revealed that the decay of contact probabilities with the genomic distance in interphase chromosomes is practically the same as in the crumpled globule state that is formed when long polymers condense without formation of any knots. To remove knots from highly crowded chromatin, one would need an active process that should not only provide the energy to move the system from the state of topological equilibrium but also guide topoisomerase-mediated passages in such a way that knots would be efficiently unknotted instead of making the knots even more complex. We perform coarse-grained molecular dynamics simulations of the process of chromatin loop extrusion involving knotted and catenated chromatin fibres to check whether chromatin loop extrusion may be involved in active unknotting of chromatin fibres. Our simulations show that the process of chromatin loop extrusion is ideally suited to actively unknot, decatenate and demix chromatin fibres in interphase chromosomes.
Hyaluronic Acid-Based Nanomaterials for Cancer Therapy
Authors: Kim Jin Hong , Moon Myeong Ju , Kim Dong Yi , Heo Suk Hee , Jeong Yong Yeon
Published: October 2018

Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan and a major component of the extracellular matrix. HA is overexpressed by numerous tumor cells, especially tumor-initiating cells. HA-based nanomaterials play in importance role in drug delivery systems. HA is used in various types of nanomaterials including micelle, polymersome, hydrogel, and inorganic nanoparticle formulations. Many experiments show that HA-based nanomaterials can serve as a platform for targeted chemotherapy, gene therapy, immunotherapy, and combination therapy with good potential for future biomedical applications in cancer treatment.
Enhanced Adsorption of Bisphenol A from Aqueous Solution with 2-Vinylpyridine Functionalized Magnetic Nanoparticles
Authors: Li Qiang , Pan Fei , Li Wentao , Li Dongya , Xu Haiming , Xia Dongsheng , Li Aimin
Published: October 2018

In this study, a novel 2-vinylpyridine functionalized magnetic nanoparticle (Mag-PVP) was successfully prepared. The prepared Mag-PVP was characterized by transmission electronic microscopy (TEM), Fourier transform infrared spectrophotometry (FT-IR), vibrating sample magnetometry (VSM) and thermogravimetric analysis (TGA), and was used for the adsorption of bisphenol A (BPA) from aqueous solutions. Mag-PVP, which is composed of Fe3O4 nanoparticles and poly divinylbenzene-2-vinylpyridine (with a thickness of 10 nm), exhibited magnetic properties (Ms = 44.6 emu/g) and thermal stability. The maximum adsorption capacity (Qm) of Mag-PVP for BPA obtained from the Langmuir isotherm was 115.87 mg/g at 20 °C, which was more than that of Fe3O4 nanospheres. In the presence of NaCl, the improved adsorption capacity of Mag-PVP was probably attributed to the screening effect of Mag-PVP surface charge and salting-out effect. In the presence of CaCl2 and humic acid (HA), the adsorption capacity of BPA decreased due to competitive adsorption. The adsorption of BPA by Mag-PVP increased slightly with the increase in pH from 3.0 to 5.0 and obtained the largest adsorption amount at pH 5.0, which was probably attributed to hydrogen bonding interactions. Moreover, in actual water, Mag-PVP still showed excellent adsorption performance in removing BPA. The high adsorption capacity and excellent reusability performance in this work indicated that Mag-PVP was an effective adsorbent for removing BPA from aqueous solutions.
Non-Viral Transfection of Human T Lymphocytes
Authors: Riedl Simon A. B. , Kaiser Patrick , Raup Alexander , Synatschke Christopher V. , Jérôme Valérie , Freitag Ruth
Published: October 2018

The genetic modification of human T lymphocytes with established non-viral methods is inefficient. Linear polyethylenimine (l-PEI), one of the most popular non-viral transfection agents for mammalian cells in general, only achieves transfection rates in the single digit percentage range for these cells. Here, a well-defined 24-armed poly(2-dimethylamino) ethyl methacrylate (PDMAEMA) nanostar (number average of the molecular weight: 755 kDa, polydispersity: <1.21) synthesized via atom transfer radical polymerization (ATRP) from a silsesquioxane initiator core is proposed as alternative. The agent is used to prepare polyplexes with plasmid DNA (pDNA). Under optimal conditions these polyplexes reproducibly transfect >80% of the cells from a human T-cell leukemia cell line (Jurkat cells) at viabilities close to 90%. The agent also promotes pDNA uptake when simply added to a mixture of cells and pDNA. This constitutes a particular promising approach for efficient transient transfection at large scale. Finally, preliminary experiments were carried out with primary T cells from two different donors. Results were again significantly better than for l-PEI, although further research into the response of individual T cells to the transfection agent will be necessary, before either method can be used to routinely transfect primary T lymphocytes.
Microencapsulation of Purple Cactus Pear Fruit (Opuntia ficus indica) Extract by the Combined Method W/O/W Double Emulsion-Spray Drying and Conventional Spray Drying: A Comparative Study
Authors: Toledo-Madrid Keren , Gallardo-Velázquez Tzayhrí , Osorio-Revilla Guillermo
Published: October 2018

The aim of this study was to microencapsulate an optimized extract of purple cactus pear fruit (Opuntia ficus indica), rich in phenolic compounds (PC), betacyanins (BC), and betaxanthins (BX), with antioxidant capacity (AC), by two methodologies: combined water-in-oil-in-water double emulsions-spray drying (W/O/W-SP) and conventional spray drying, studying the effect of spray drying (SP) on PC and AC. Optimal extraction conditions for bioactive compounds were: 52 °C, for 30 min, using aqueous ethanol (40%w/w) as the solvent, with a 0.85 desirability function, obtaining 17.39 ± 0.11 mg GAE/gdw (gallic acid equivalents per gram of dry weight) for PC, 0.35 mg BE/gdw (betanin equivalents per gram of dry weight) for BC, and 0.26 mg IE/gdw (indicaxanthin equivalents per gram of dry weight) for BX. The best combination of temperatures for conventional SP and W/O/W-SP was 160–80 °C obtaining the highest retention and encapsulation efficiencies for PC. For conventional SP, results were: 107% and 100% PC and AC retention efficiencies (RE-PC and RE-AC), respectively, with 97% of PC encapsulation efficiency (EE-PC), meanwhile for the W/O/W-SP results were: 78% and 103% RE-PC and RE-AC, respectively, with 70% of EE-PC. Microcapsules obtained with W/O/W-SP maintained their structure and integrity and showed a considerable reduction in globule size in the reconstituted W/O/W emulsions due to the spray drying stress. Despite having lower EE-PC than conventional SP, spray dried W/O/W emulsions seem as a promising controlled-delivery vehicle for antioxidant compounds.
Shaping the Religiosity of Chinese University Students: Science Education and Political Indoctrination
Authors: Li Miao , Lu Yun , Yang Fenggang
Published: October 2018

Our study examined the respective relationships between two components of higher education in mainland China—science education and political indoctrination—and the religiosity of university students. Using a cross-sectional, representative sample of about 1700 college students in Beijing, we found first that students studying natural/applied sciences were less likely to perceive Protestantism, Catholicism, and Islam as plausible and less likely to have supernatural belief, relative to students in humanities/social sciences. In addition, the more students positively evaluated the political education courses—which indicates students’ acceptance of political indoctrination—the less likely they reported Protestantism and Catholicism as being plausible. Nevertheless, neither science education nor political indoctrination was associated with the perceived plausibility of Buddhism and Daoism or the worshipping behavior of students. We discuss the implications of these findings in light of the secularization debate and the research on education, religion, and state atheism.
Challenging Moderate Muslims: Indonesia’s Muslim Schools in the Midst of Religious Conservatism
Authors: Zuhdi Muhammad
Published: October 2018

Muslim schools are an important element of education in Indonesia. The school was in place long before Indonesia’s independence in 1945. Schools educate Indonesian Muslim children to understand and practice religion while promoting a sense of nationalism. Thanks to Muslim schools, Indonesian Muslims are recognized as being moderate. Recently, however, the moderate nature of Indonesian Islam is challenged by the spirit of conservative Islam. The question is how Muslim schools play their roles in the discourse of moderate versus conservative Muslims. This study identified five issues that are largely discussed among Indonesian Muslims: Islam and state, Muslims–non Muslims relations, non-mainstream Islam, gender, and media. Knowing that there is a strong relationship between society and education, i.e., religious education, it is important to see the relationship between schools and society including how the current conservative trend in Indonesian Islam is being taught at schools. This study explored how the curriculum of (Islamic) religious education potentially contributes toward the development of Indonesian conservative Muslims and how religious education teachers view sensitive issues concerning conservative Islam. To answer these questions, the analysis of religious education curricula and the interviewing of teachers serve as the primary methods of data collection. Four religious education teachers from different provinces of Indonesia were interviewed to reveal their opinions on various religion-related issues. This paper discusses how Islamic education in Indonesia has been designed to present moderate Islam but, at the same time, faces a number of challenges that try to turn religious education into conservative religious doctrines.
Towards a Typology of Battlefield Miracles: The Case of Operation “Cast Lead” in the Israel Defense Forces
Authors: Rosman Elisheva
Published: October 2018

Battlefield miracle stories are not rare. This paper suggests a typology of battlefield miracles. From this perspective it asks what sort of miracles can we expect to see in battle and when can we expect to see them? After presenting the main points of discussion regarding miracles, it proposes a range of categories for military miracles (miracles as acts that violate nature versus miracles as everyday acts; those involving the divine versus occurrences not requiring the presence of a heavenly emissary; acts of benevolence versus acts with no such intent; having a clear purpose versus acts where there is disagreement regarding interpretation). After discussing these categories, the articles uses Operation Cast Lead (December 2008–January 2009) as a case study to test the typology suggested above. Since this field is underdeveloped, this paper sets out to initiate a conversation on battlefield miracles, with hope that future studies will build upon it.
RMB Exchange Rates and Volatility Spillover across Financial Markets in China and Japan
Authors: Qin Fengming , Zhang Junru , Zhang Zhaoyong
Published: October 2018

This study examines empirically the volatility spillover effects between the RMB foreign exchange markets and the stock markets by employing daily returns of the Chinese RMB exchange rates and the stock markets in China and Japan during the period in 1998–2018. We find evidence that there exist co-volatility effects among the financial markets in China and Japan, and the volatility of RMB exchange rates contribute to the co-volatility spillovers across the financial markets. Reversely, the return shock from the stock markets can also generate co-volatility spillover to the foreign exchange markets. The bidirectional relationship reveals that both the fundamental hypothesis and the investor-induced hypothesis are valid. Our estimates also show that the spillover effects led by the stock market in Japan are stronger than that from the foreign exchange markets and the Chinese stock markets, implying that market with higher accessibility has greater spillover effects onto other markets. We also found that the average co-volatility spillover effects among the RMB exchange markets and the stock markets in Japan and China are generally negative. These findings have important policy implications for risk management and hedging strategies.
Spacecraft Robot Kinematics Using Dual Quaternions
Authors: Valverde Alfredo , Tsiotras Panagiotis
Published: October 2018

In recent years, there has been a growing interest in servicing orbiting satellites. In most cases, in-orbit servicing relies on the use of spacecraft-mounted robotic manipulators to carry out complicated mission objectives. Dual quaternions, a mathematical tool to conveniently represent pose, has recently been adopted within the space industry to tackle complex control problems during the stages of proximity operations and rendezvous, as well as for the dynamic modeling of robotic arms mounted on a spacecraft. The objective of this paper is to bridge the gap in the use of dual quaternions that exists between the fields of spacecraft control and fixed-base robotic manipulation. In particular, we will cast commonly used tools in the field of robotics as dual quaternion expressions, such as the Denavit-Hartenberg parameterization, or the product of exponentials formula. Additionally, we provide, via examples, a study of the kinematics of different serial manipulator configurations, building up to the case of a completely free-floating robotic system. We provide expressions for the dual velocities of the different types of joints that commonly arise in industrial robots, and we end by providing a collection of results that cast convex constraints commonly encountered by space robots during proximity operations in terms of dual quaternions.
Slim and Efficient Neural Network Design for Resource-Constrained SAR Target Recognition
Authors: Chen Hongyi , Zhang Fan , Tang Bo , Yin Qiang , Sun Xian
Published: October 2018

Deep convolutional neural networks (CNN) have been recently applied to synthetic aperture radar (SAR) for automatic target recognition (ATR) and have achieved state-of-the-art results with significantly improved recognition performance. However, the training period of deep CNN is long, and the size of the network is huge, sometimes reaching hundreds of megabytes. These two factors of deep CNN hinders its practical implementation and deployment in real-time SAR platforms that are typically resource-constrained. To address this challenge, this paper presents three strategies of network compression and acceleration to decrease computing and memory resource dependencies while maintaining a competitive accuracy. First, we introduce a new weight-based network pruning and adaptive architecture squeezing method to reduce the network storage and the time of inference and training process, meanwhile maintain a balance between compression ratio and classification accuracy. Then we employ weight quantization and coding to compress the network storage space. Due to the fact that the amount of calculation is mainly reflected in the convolution layer, a fast approach for pruned convolutional layers is proposed to reduce the number of multiplication by exploiting the sparsity in the activation inputs and weights. Experimental results show that the convolutional neural networks for SAR-ATR can be compressed by 40 × without loss of accuracy, and the number of multiplication can be reduced by 15 × . Combining these strategies, we can easily load the network in resource-constrained platforms, speed up the inference process to get the results in real-time or even retrain a more suitable network with new image data in a specific situation.
Wearable Carbon Nanotube-Based Biosensors on Gloves for Lactate
Authors: Luo Xiaojin , Shi Weihua , Yu Haoming , Xie Zhaoyang , Li Kunyi , Cui Yue
Published: October 2018

Developing a simple and direct approach for interfacing a sensor and a target analyte is of great interest for fields such as medical diagnosis, threat detection, food quality control, and environmental monitoring. Gloves provide a unique interface for sensing applications. Here, we show for the first time the development of wearable carbon nanotube (CNT)-based amperometric biosensors painted onto gloves as a new sensing platform, used here for the determination of lactate. Three sensor types were studied, configured as: two CNT electrodes; one CNT electrode, and an Ag/AgCl electrode, and two CNT electrodes and an Ag/AgCl electrode. The sensors are constructed by painting the electrodes using CNT or Ag/AgCl inks. By immobilizing lactate oxidase onto the CNT-based working electrodes, the sensors show sensitive detections of lactate. Comparison of sensor performance shows that a combination of CNT and Ag/AgCl is necessary for highly sensitive detection. We anticipate that these findings could open exciting avenues for fundamental studies of wearable bioelectronics, as well as practical applications in fields such as healthcare and defense.
NCA-Net for Tracking Multiple Objects across Multiple Cameras
Authors: Tan Yihua , Tai Yuan , Xiong Shengzhou
Published: October 2018

Tracking multiple pedestrians across multi-camera scenarios is an important part of intelligent video surveillance and has great potential application for public security, which has been an attractive topic in the literature in recent years. In most previous methods, artificial features such as color histograms, HOG descriptors and Haar-like feature were adopted to associate objects among different cameras. But there are still many challenges caused by low resolution, variation of illumination, complex background and posture change. In this paper, a feature extraction network named NCA-Net is designed to improve the performance of multiple objects tracking across multiple cameras by avoiding the problem of insufficient robustness caused by hand-crafted features. The network combines features learning and metric learning via a Convolutional Neural Network (CNN) model and the loss function similar to neighborhood components analysis (NCA). The loss function is adapted from the probability loss of NCA aiming at object tracking. The experiments conducted on the NLPR_MCT dataset show that we obtain satisfactory results even with a simple matching operation. In addition, we embed the proposed NCA-Net with two existing tracking systems. The experimental results on the corresponding datasets demonstrate that the extracted features using NCA-net can effectively make improvement on the tracking performance.
Highly Sensitive Humidity Sensor Based on Oblique Carbon Nanoplumes
Authors: Qiao Siqi , Peng Xiaoyan , Wang Lidan , Duan Shukai , Chu Jin , Jia Pengfei
Published: October 2018

In this work, we fabricated three carbon nanoplume structured samples under different temperatures using a simple hot filament physical vapor deposition (HFPVD) process, and investigated the role of surface morphology, defects, and graphitic content on relative humidity (RH) sensing performances. The Van der Drift growth model and oblique angle deposition (OAD) technique of growing a large area of uniformly aligned and inclined oblique arrays of carbon nanoplumes (CNPs) on a catalyst-free silicon substrate was demonstrated. The optimal growing temperature of 800 °C was suitable for the formation of nanoplumes with larger surface area, more defect sites, and less graphitic content, compared to the other samples that were prepared. As expected, a low detection limit, high response, capability of reversible behavior, and rapid response/recovery speed with respect to RH variation, was achieved without additional surface modification or chemical functionalization. The holes’ depletion has been described as a RH sensing mechanism that leads to the increase of the conduction of the CNPs with increasing RH levels.
StraightenUp+: Monitoring of Posture during Daily Activities for Older Persons Using Wearable Sensors
Authors: Cajamarca Gabriela , Rodríguez Iyubanit , Herskovic Valeria , Campos Mauricio , Riofrío Juan Carlos
Published: October 2018

Monitoring the posture of older persons using portable sensors while they carry out daily activities can facilitate the process of generating indicators with which to evaluate their health and quality of life. The majority of current research into such sensors focuses primarily on their functionality and accuracy, and minimal effort is dedicated to understanding the experience of older persons who interact with the devices. This study proposes a wearable device to identify the bodily postures of older persons, while also looking into the perceptions of the users. For the purposes of this study, thirty independent and semi-independent older persons undertook eight different types of physical activity, including: walking, raising arms, lowering arms, leaning forward, sitting, sitting upright, transitioning from standing to sitting, and transitioning from sitting to standing. The data was classified offline, achieving an accuracy of 93.5%, while overall device user perception was positive. Participants rated the usability of the device, in addition to their overall user experience, highly.
Analysis of Human Body Shadowing Effect on Wireless Sensor Networks Operating in the 2.4 GHz Band
Authors: Januszkiewicz Łukasz
Published: October 2018

Miniaturized wireless sensors are designed to run on limited power resources, requiring minimization of transmit power and lowering of the fade margin in the link budget. One factor that has an important impact on wireless sensor network design is path loss between the transmitter and the receiver. This paper presents an analysis of the influence of human bodies on path loss in the 2.4 GHz band, which is commonly used for wireless sensor networks. The effect of body shadowing was first analyzed in full wave computer simulations using the finite-difference time-domain method. Due to the high numerical burden, the simulations were limited to only a small region around the human body. To analyze the performance of networks in larger indoor environments, a human body model is proposed that can be used for simulations with a ray-based computer program. The proposed model of human body is the main contribution of this paper. It was used to analyze the body shadowing effect in a typical indoor environment. The results were found to be in good agreement with measurements.
Mutually Coupled Time-to-Digital Converters (TDCs) for Direct Time-of-Flight (dTOF) Image Sensors ‡
Authors: Ronchini Ximenes Augusto , Padmanabhan Preethi , Charbon Edoardo
Published: October 2018

Direct time-of-flight (dTOF) image sensors require accurate and robust timing references for precise depth calculation. On-chip timing references are well-known and understood, but for imaging systems where several thousands of pixels require seamless references, area and power consumption limit the use of more traditional synthesizers, such as phase/delay-locked loops (PLLs/DLLs). Other methods, such as relative timing measurement (start/stop), require constant foreground calibration, which is not feasible for outdoor applications, where conditions of temperature, background illumination, etc. can change drastically and frequently. In this paper, a scalable reference generation and synchronization is provided, using minimum resources of area and power, while being robust to mismatches. The suitability of this approach is demonstrated through the design of an 8 × 8 time-to-digital converter (TDC) array, distributed over 1.69 mm2, fabricated using TSMC 65 nm technology (1.2 V core voltage and 4 metal layers—3 thin + 1 thick). Each TDC is based on a ring oscillator (RO) coupled to a ripple counter, occupying a very small area of 550 μ m2, while consuming 500 μ W of power, and has 2 μ s range, 125 ps least significant bit (LSB), and 14-bit resolution. Phase and frequency locking among the ROs is achieved, while providing 18 dB phase noise improvement over an equivalent individual oscillator. The integrated root mean square (RMS) jitter is less than 9 ps, the instantaneous frequency variation is less than 0.11%, differential nonlinearity (DNL) is less than 2 LSB, and integral nonlinearity (INL) is less than 3 LSB.
Value of Information Based Data Retrieval in UWSNs
Authors: Khan Fahad Ahmad , Butt Sehar , Khan Saad Ahmad , Bölöni Ladislau , Turgut Damla
Published: October 2018

Sensor nodes in underwater sensor networks may acquire data at a higher rate than their ability to communicate over underwater acoustic channels. Autonomous underwater vehicles may mitigate this mismatch by offloading high volumes of data from the sensor nodes and ferrying them to the sink. Such a mode of data transfer results in high latency. Occasionally, these networks need to report high priority events such as catastrophes or intrusions. In such a scenario the expectation is to have a minimal end-to-end delay for event reporting. Considering this, underwater vehicles should schedule their visits to the sensor nodes in a manner that aids efficient reporting of high-priority events. We propose the use of the Value of Information metric in order to improve the reporting of events in an underwater sensor network. The proposed approach classifies the recorded data in terms of its value and priority. The classified data is transmitted using a combination of acoustic and optical channels. We perform experiments with a binary event model, i.e., we classify the events into high-priority and low-priority events. We explore a couple of different path planning strategies for the autonomous underwater vehicle. Our results show that scheduling visits to sensor nodes, based on algorithms that address the value of information, improves the timely reporting of high priority data and enables the accumulation of larger value of information.
Scanning Laser Rangefinders for the Unobtrusive Monitoring of Gait Parameters in Unsupervised Settings
Authors: Fudickar Sebastian , Stolle Christian , Volkening Nils , Hein Andreas
Published: October 2018

Since variations in common gait parameters (such as cadence, velocity and stride-length) of elderly people are a reliable indicator of functional and cognitive decline in aging and increased fall risks, such gait parameters have to be monitored continuously to enable preventive interventions as early as possible. With scanning laser rangefinders (SLR) having been shown to be suitable for standardised (frontal) gait assessments, this article introduces an unobtrusive gait monitoring (UGMO) system for lateral gait monitoring in homes for the elderly. The system has been evaluated in comparison to a GAITRite (as reference system) with 86 participants (ranging from 21 to 82 years) passing the 6-min walk test twice. Within the considered 56,351 steps within an overall 7877 walks and approximately 34 km distance travelled, it has been shown that the SLR Hokuyo UST10-LX is more sensitive than the cheaper URG-04LX version in regard to the correct (automatic) detection of lateral steps (98% compared to 77%) and walks (97% compared to 66%). Furthermore, it has been confirmed that the UGMO (with the SLR UST10-LX) can measure gait parameters such as gait velocity and stride length with sufficient sensitivity to determine age- and disease-related functional (and cognitive) decline.
Analysis of Errors in the Estimation of Impact Positions in Plate-Like Structure through the Triangulation Formula by Piezoelectric Sensors Monitoring
Authors: Marino-Merlo Eugenio , Bulletti Andrea , Giannelli Pietro , Calzolai Marco , Capineri Lorenzo
Published: October 2018

The structural health monitoring (SHM) of critical structures is a complex task that involves the use of different sensors that are also aimed at the identification of the location of the impact point using ultrasonic sensors. For the evaluation of the impact position, reference is often made to the well-known triangulation method. This method requires the estimation of the differential time of arrival (DToA) and the group velocity of the Lamb waves propagating into a plate-like structure: the uncertainty of these two parameters is taken into consideration as main cause of localization error. The work proposes a simple laboratory procedure based on a set-up with a pair of sensors that are symmetrically placed with respect to the impact point, to estimate the uncertainty of the DToA and the propagation velocity estimates. According to a theoretical analysis of the error for the impact position, the experimental uncertainties of DToA and the propagation velocity are used to estimate the overall limit of the SHM system for the impact positioning. Because the error for the DToA estimate depends also on the adopted signal processing, three common methods are selected and compared: the threshold, the correlation method, and a likelihood algorithm. Finally, the analysis of the positioning error using multisensory configuration is reported as useful for the design of the SHM system.
LiDAR-Based Non-Cooperative Tumbling Spacecraft Pose Tracking by Fusing Depth Maps and Point Clouds
Authors: Zhao Gaopeng , Xu Sixiong , Bo Yuming
Published: October 2018

How to determine the relative pose between the chaser spacecraft and the high-speed tumbling target spacecraft at close range, which is an essential step in space proximity missions, is very challenging. This paper proposes a LiDAR-based pose tracking method by fusing depth maps and point clouds. The key point is to estimate the roll angle variation in adjacent sensor data by using the line detection and matching in depth maps. The simplification of adaptive voxelized grid point cloud based on the real-time relative position is adapted in order to satisfy the real-time requirement in the approaching process. In addition, the Iterative Closest Point algorithm is used to align the simplified sparse point cloud with the known target model point cloud in order to obtain the relative pose. Numerical experiments, which simulate the typical tumbling motion of the target and the approaching process, are performed to demonstrate the method. The experimental results show that the method has capability of estimating the real-time 6-DOF relative pose and dealing with large pose variations.