bluuebunny/crossref_metadata_2025 huggingface dataset:
Technical Note—A Robust Perspective on Transaction Costs in Portfolio Optimization
Authors: Olivares-Nadal Alba V. , DeMiguel Victor
Published: May 2018

We prove that the portfolio problem with transaction costs is equivalent to three different problems designed to alleviate the impact of estimation error: a robust portfolio optimization problem, a regularized regression problem, and a Bayesian portfolio problem. Motivated by these results, we propose a data-driven approach to portfolio optimization that tackles transaction costs and estimation error simultaneously by treating the transaction costs as a regularization term to be calibrated. Our empirical results demonstrate that the data-driven portfolios perform favorably because they strike an optimal trade-off between rebalancing the portfolio to capture the information in recent historical return data and avoiding the large transaction costs and impact of estimation error associated with excessive trading.

The online companion is available at https://doi.org/10.1287/opre.2017.1699 .
Investigation and characterization of insect secretion on Albazia tree as biobased material alternative for matrix composite
Authors: Mujiyono Mujiyono. , Jamasri Jamasri. , Heru Santoso B. R. , Sutapa J. P. Gentur
Published: May 2018

The people of Ciamis regency, West Java district, Indonesia have been using biobased material to patch the tin roof, to join rod of machete and rod of hoe. They call it with the term "ant's house". This paper reports the investigation and characterization of the material as an alternative material for biobased composite matrix. Investigations were carried out in the traditional market Ciganjeng, Padaheurang, and Banjarsari subdistrict, Ciamis regency, West Java District, to obtain samples of the biobased material and collect information related to the main sources location. The sample was characterized by FTIR to predict functional group and SEM-EDAX to count mass of its chemical structure. Polarity and visualization of samples were done to prove the chemical structure prediction of the material. The results of the investigation and characterization showed that the sample is lac secretion of of insect that live on Albazia tree, so it is not the "ant's house". The main source location of the material is mountain area of Karangnangka village, Banjarsari subdistrict, Ciamis regency of West Java district. The chemical structure of the biobased materials is aleuretic acid. The next paper will report engineering aspect of matrix composite from this biobased material alternative.
Mechanical Properties of Aluminum/fly Ash Composites Produced by Hot Extrusion
Authors: Subarmono Subarmono. , Jamasri Jamasri. , Wildan M. W. , Kusnanto Kusnanto.
Published: May 2018

This research aims to investigate mechanical properties of aluminum matrix composites reinforced with fly ash (AMC/Fly ash) produced using hot extrusion.AMC/Fly ash was prepared from aluminum fine powder as matrix and fly ash as reinforcement. The various amount of fly ash of 5%; 7.5%; 10%; 12.5% and 15% wt were added to the aluminum fine powder. Each composition was mixed using rotary mixer for 3 hours. The mixture was compacted using uniaxial pressing with a pressure of 100 MPa to produce green body. The green body was hot extruded with an extrusion ratio of 0.25 and temperature of 600ºC. Bending strength, Vickers hardness, wear rate and porosity of the AMC/fly ash were measured. The microstructure was observed using SEM. The results show that mechanical properties of the composites such as bending strength and Vickers hardness increase, porosity and wear rate decrease with increasing fly ash content up to 12.5 wt %. Above 12.5 wt % of fly ash those mechanical properties of composites seems to be inverse. The properties of AMC/12.5 wt % fly ash produced using hot extrusion from green body showing the best properties in term of the bending strength, Vickers hardness, porosity and wear resistance, that are 302 MPa; 79 VHN; 0.73 % and 0,0095 mg/(MPa.m), respectively.
When Memory and Sexuality Collide: The Homosentimental Style of Gay Liberation
Authors: Reyes G. Mitchell , Schulz David P. , Hovland Zoe
Published: May 2018

Commemorating both the Stonewall Riots of 1969 and the subsequent Gay Liberation Movement, the Gay Liberation Monument projects a quiet, muted homosexuality that stands in sharp contrast to the courageous and violent assertion of homosexual identity that was Stonewall. Our essay examines this strange incongruity, revealing in the process the homosentimental style—a unique rhetorical form that attempts to negotiate the many contradictory motives animating LGBT advocacy. The Gay Liberation Monument’s use of homosentimentality refracts in many directions, simultaneously challenging dehumanizing rhetorics with affective appeals to care and friendship, presenting itself as assimilationist even as it offers coded indices of clone culture, and producing a doubled homosexual body—at once assimilationist and queer. Both the monument and the homosentimental style thus pose a challenge to binary conceptualizations of LGBT rights advocacy that separate assimilationist and queer politics.
“A Spirit That Can Never Be Told”: Commemorative Agency and the Texas A&M University Bonfire Memorial
Authors: Gaffey Adam J. , Barbour Jennifer L. Jones
Published: May 2018

On November 18, 1999, Texas A&M University (TAMU) experienced profound tragedy when the famed Aggie Bonfire collapsed, killing 12 students and injuring 27 others. This essay examines the rhetorical dynamics of the TAMU Bonfire Memorial and explores how it navigates the tension created when a constitutive symbol is implicated in a moment of tragedy. Specifically, we use this case to explore how memorials help shape perceptions of victim agency in commemorative form. As we argue, the memorial taps into resonant modes of public reasoning—including temporal metaphors, Christian theology, and campus tradition—to imply the tragic outcome of the 1999 collapse had cause beyond human or institutional control. Our analysis of the Bonfire Memorial illustrates the importance of commemorative agency and, in particular, how eliding victim agency can limit epideictic encounters that might foster a sense of present and future engagement on unreconciled issues.
Conjunctive queries with inequalities under updates
Authors: Idris Muhammad , Ugarte Martín , Vansummeren Stijn , Voigt Hannes , Lehner Wolfgang
Published: May 2018

Modern application domains such as Composite Event Recognition (CER) and real-time Analytics require the ability to dynamically refresh query results under high update rates. Traditional approaches to this problem are based either on the materialization of subresults (to avoid their recomputation) or on the recomputation of subresults (to avoid the space overhead of materialization). Both techniques have recently been shown suboptimal: instead of materializing results and subresults, one can maintain a data structure that supports efficient maintenance under updates and can quickly enumerate the full query output, as well as the changes produced under single updates. Unfortunately, these data structures have been developed only for aggregate-join queries composed of equi-joins, limiting their applicability in domains such as CER where temporal joins are commonplace. In this paper, we present a new approach for dynamically evaluating queries with multi-way
θ
-joins under updates that is effective in avoiding both materialization and recomputation of results, while supporting a wide range of applications. To do this we generalize Dynamic Yannakakis, an algorithm for dynamically processing acyclic equi-join queries. In tandem, and of independent interest, we generalize the notions of acyclicity and free-connexity to arbitrary
θ
-joins. We instantiate our framework to the case where
θ
-joins are only composed of equalities and inequalities (<, ≤, =, >, ≥) and experimentally compare this algorithm, called IEDyn, to state of the art CER systems as well as incremental view maintenance engines. IEDyn performs consistently better than the competitor systems with up to two orders of magnitude improvements in both time and memory consumption.
Selecting subexpressions to materialize at datacenter scale
Authors: Jindal Alekh , Karanasos Konstantinos , Rao Sriram , Patel Hiren
Published: May 2018

We observe significant overlaps in the computations performed by user jobs in modern shared analytics clusters. Naïvely computing the same subexpressions multiple times results in wasting cluster resources and longer execution times. Given that these shared cluster workloads consist of tens of thousands of jobs, identifying overlapping computations across jobs is of great interest to both cluster operators and users. Nevertheless, existing approaches support orders of magnitude smaller workloads or employ heuristics with limited effectiveness.

In this paper, we focus on the problem of subexpression selection for large workloads, i.e., selecting common parts of job plans and materializing them to speed-up the evaluation of subsequent jobs. We provide an ILP-based formulation of our problem and map it to a bipartite graph labeling problem. Then, we introduce B
ig
S
ubs
, a vertex-centric graph algorithm to iteratively choose in parallel which subexpressions to materialize and which subexpressions to use for evaluating each job. We provide a distributed implementation of our approach using our internal SQL-like execution framework, SCOPE, and assess its effectiveness over production workloads. B
ig
S
ubs
supports workloads with tens of thousands of jobs, yielding savings of up to 40% in machine-hours. We are currently integrating our techniques with the SCOPE runtime in our production clusters.
Scalable training of hierarchical topic models
Authors: Chen Jianfei , Zhu Jun , Lu Jie , Liu Shixia
Published: May 2018

Large-scale topic models serve as basic tools for feature extraction and dimensionality reduction in many practical applications. As a natural extension of flat topic models, hierarchical topic models (HTMs) are able to learn topics of different levels of abstraction, which lead to deeper understanding and better generalization than their flat counterparts. However, existing scalable systems for flat topic models cannot handle HTMs, due to their complicated data structures such as trees and concurrent dynamically growing matrices, as well as their susceptibility to local optima.

In this paper, we study the hierarchical latent Dirichlet allocation (hLDA) model which is a powerful nonparametric Bayesian HTM. We propose an efficient partially collapsed Gibbs sampling algorithm for hLDA, as well as an initialization strategy to deal with local optima introduced by tree-structured models. We also identify new system challenges in building scalable systems for HTMs, and propose efficient data layout for vectorizing HTM as well as distributed data structures including dynamic matrices and trees. Empirical studies show that our system is 87 times more efficient than the previous open-source implementation for hLDA, and can scale to thousands of CPU cores. We demonstrate our scalability on a 131-million-document corpus with 28 billion tokens, which is 4--5 orders of magnitude larger than previously used corpus. Our distributed implementation can extract 1,722 topics from the corpus with 50 machines in just 7 hours.
Table union search on open data
Authors: Nargesian Fatemeh , Zhu Erkang , Pu Ken Q. , Miller Renée J.
Published: May 2018

We define the table union search problem and present a probabilistic solution for finding tables that are unionable with a query table within massive repositories. Two tables are
unionable
if they share attributes from the same domain. Our solution formalizes three statistical models that describe how unionable attributes are generated from set domains, semantic domains with values from an ontology, and natural language domains. We propose a data-driven approach that automatically determines the best model to use for each pair of attributes. Through a distribution-aware algorithm, we are able to find the optimal number of attributes in two tables that can be unioned. To evaluate accuracy, we created and open-sourced a benchmark of Open Data tables. We show that our table union search outperforms in speed and accuracy existing algorithms for finding related tables and scales to provide efficient search over Open Data repositories containing more than one million attributes.
Indexed fast network proximity querying
Authors: Coşkun Mustafa , Grama Ananth , Koyutürk Mehmet
Published: May 2018

Node proximity queries are among the most common operations on network databases. A common measure of node proximity is random walk based proximity, which has been shown to be less susceptible to noise and missing data. Real-time processing of random-walk based proximity queries poses significant computational challenges for larger graphs with over billions of nodes and edges, since it involves solution of large linear systems of equations. Due to the importance of this operation, significant effort has been devoted to developing efficient methods for random-walk based node proximity computations. These methods either aim to speed up iterative computations by exploiting numerical properties of random walks, or rely on computation and storage of matrix inverses to avoid computation during query processing. Although both approaches have been well studied, the speedup achieved by iterative approaches does not translate to real-time query processing, and the storage requirements of inversion-based approaches prohibit their use on very large graph databases.

We present a novel approach to significantly reducing the computational cost of random walk based node proximity queries with scalable indexing. Our approach combines domain graph-partitioning based indexing with fast iterative computations during query processing using Chebyshev polynomials over the complex elliptic plane. This approach combines the query processing benefits of inversion techniques with the memory and storage benefits of iterative approache. Using real-world networks with billions of nodes and edges, and top-
k
proximity queries as the benchmark problem, we show that our algorithm, I-C
hopper
, significantly outperforms existing methods. Specifically, it drastically reduces convergence time of the iterative procedure, while also reducing storage requirements for indexing.
Discovery of genuine functional dependencies from relational data with missing values
Authors: Berti-Équille Laure , Harmouch Hazar , Naumann Felix , Novelli Noël , Thirumuruganathan Saravanan
Published: May 2018

Functional dependencies (FDs) play an important role in maintaining data quality. They can be used to enforce data consistency and to guide repairs over a database. In this work, we investigate the problem of missing values and its impact on FD discovery. When using existing FD discovery algorithms, some genuine FDs could not be detected precisely due to missing values or some non-genuine FDs can be discovered even though they are caused by missing values with a certain NULL semantics. We define a notion of genuineness and propose algorithms to compute the genuineness score of a discovered FD. This can be used to identify the
genuine FDs
among the set of all valid dependencies that hold on the data. We evaluate the quality of our method over various real-world and semi-synthetic datasets with extensive experiments. The results show that our method performs well for relatively large FD sets and is able to accurately capture genuine FDs.
LA3
Authors: Ahmad Yousuf , Khattab Omar , Malik Arsal , Musleh Ahmad , Hammoud Mohammad , Kutlu Mucahid , Shehata Mostafa , Elsayed Tamer
Published: May 2018

This paper presents
LA3
, a scalable distributed system for graph analytics. LA3 couples a vertex-based programming model with a highly optimized linear algebra-based engine. It translates any vertex-centric program into an iteratively executed sparse matrix-vector multiplication (SpMV). To reduce communication and enhance scalability, the adjacency matrix representing an input graph is partitioned into locality-aware 2D tiles distributed across multiple processes. Alongside, three major optimizations are incorporated to preclude redundant computations and minimize communication. First, the link-based structure of the input graph is exploited to classify vertices into different types. Afterwards, vertices of special types are factored out of the main loop of the graph application to avoid superfluous computations. We refer to this novel optimization as
computation filtering.
Second, a
communication filtering
mechanism is involved to optimize for the high sparsity of the input matrix due to power-law distributions, common in real-world graphs. This optimization ensures that each process receives only the messages that pertain to non-zero entries in its tiles, substantially reducing communication traffic since most tiles are highly sparse. Lastly, a
pseudo-asynchronous computation and communication
optimization is proposed, whereby processes progress and communicate asynchronously, consume messages as soon as they become available, and block otherwise. We implemented and extensively tested LA3 on private and public clouds. Results show that LA3 outperforms six related state-of-the-art and popular distributed graph analytics systems by an average of 10X.
Hydrolytic and oxidative enzyme production through cultivation ofPleurotus ostreatuson pulp and paper industry wastes
Authors: Skočaj Matej , Gregori Andrej , Grundner Maja , Sepčić Kristina , Sežun Mija
Published: May 2018

The growth of oyster mushroom (Pleurotus ostreatus) on pulp and paper industry wastes was studied. Specifically, the question was investigated whether solid-state fermentation ofP. ostreatuson paper-mill deinking sludge and primary sludge substrates is appropriate for production of enzymes, relevant to the pulp and paper industry. Following fermentation, extracellular protein was extracted and the specific activities of four enzymes were determined, namely, the cellulase, xylanase, lipase and peroxidase. Furthermore, the effects of the pH of the extraction buffer on these enzyme activities were determined, along with the effects of the incubation time. The data show thatP. ostreatuscan grow on solid wastes from the pulp and paper industry, which could help to minimize the waste volume and to decrease the ecological impact. Furthermore, the solid wastes in focus are good substrates for the production of commercially interesting enzymes.
Presentation of ACT/R-RBF Hybrid Architecture to Develop Decision Making in Continuous and Non-continuous Data
Authors: Rezazadeh Nader , Banirostam Touraj
Published: May 2018

Computational models are based on symbolic architecture. For this reason, computational models function problematically in dynamic, noisy, and continuous environments. The ACT/R (Adaptive Control of Thought-Rational) model is also problematic, as it is purely based on symbolic architecture like other computational models. The ACT/R decision-making process is based on the production operator on the input subject set. This approach firstly does not make a non-linear mapping between input and the decision-making result in ACT/R. Secondly, it is not possible to decide on the input subjects with a continuous input range because of the need to introduce numerous rules. The objective of presenting the ACT/R-radial basis function (RBF) hybrid architecture method was to create a communication network between input concepts in which the reception of and decision making on a combination of subjects and symbols are possible. Moreover, a non-linear mapping between input and the decision-making result can be created. The said capabilities have been obtained by the combination of ACT/R with an RBF neural network and calculation of the decision-making centers in the said network using clustering. The empirical experiments indicate desirable results in this regard.
The tert-butylaminomethyl(mesityl)phosphinic acid ester and formation of its zinc dichloride complex: syntheses and characterization
Authors: Lutter Michael , Stratmann Lukas M. , Jurkschat Klaus
Published: May 2018

The syntheses and structures of tert-butylaminomethyl(mesityl)phosphinic acid ethyl ester 2 and its zinc dichloride complex 3 are reported. In the solid state, both compounds are dimeric via hydrogen bridges. In the complex 3, the phosphinic acid ester 2 coordinates the zinc dichloride diastereoselectively.
Carbon nanofiber reinforced thermoplastic elastomer based on polypropylene/polybutadiene blend: theoretical modeling of Young’s modulus of the nanocomposites with respect to the orientation and agglomeration of carbon nanofiber
Authors: Sreedevi P.G. , Shadiya M.A. , Rani Joseph
Published: May 2018

The effect of the concentration of carbon nanofibers (CNFs) on thermoplastic elastomer based on polypropylene/polybutadiene (PP/BR) blend (80/20) prepared by melt blending process was investigated. The morphological properties are reported in combination with the mechanical and rheological properties of the nanocomposites. The dispersion of CNFs examined by transmission electron microscopy shows uniform dispersion of CNFs in the PP matrix. The mechanical performance is found to be in line with the morphological structure observed in scanning electron microscopy. Tensile strength and Young’s modulus of the PP/BR blend increase with an increase of filler content up to 3 wt%. The modified Halpin-Tsai equation that accounts for the effect of orientation and agglomeration of CNF was used to evaluate the Young’s modulus of the nanocomposite. The dynamic rheological analysis in the frequency sweep experiment shows that the introduction of CNF in the PP/BR blend improves the complex viscosity (ƞ*), storage modulus (G′), and loss modulus (G″) in the low-frequency region.
The effects of inulin and fructo-oligosaccharide on the probiotic properties of Lactobacillus spp. isolated from human milk
Authors: Tulumoğlu Şener , Erdem Belgin , Şimşek Ömer
Published: May 2018

This study aims to determine the effects of inulin and fructo-oligosaccharide (FOS) on the probiotic properties of five Lactobacillus spp. isolated from human milk. Lactobacillus spp. were isolated and identified, and the growth characteristics, acid and bile salt tolerance, antagonistic effects, and cholesterol assimilation of Lactobacillus strains were investigated in the presence of inulin and FOS. Lactobacillus casei L1 was able to utilize inulin and FOS as carbon source as well as glucose even other strains were able to use, including Lactobacillus rhamnosus GG. This strain also showed high tolerance to acid and bile salt, even at pH 2.5 and 0.5% bile salt levels, respectively. Inulin and FOS promoted the antimicrobial activity of L. casei L1 against pathogenic bacteria. Cholesterol assimilation was higher than in the other and control probiotic strains in the presence inulin and FOS, which were measured as 14 and 25 mg/dL, respectively. In conclusion, L. casei L1 can use both inulin and FOS to maintain its viability both at digestive conditions and also the relevant prebiotics, and show broad antagonistic activity and cholesterol assimilation.
Effect of Pavement Condition Monitoring Frequency with Unequal Interval on Determining Pavement Service Life
Authors: Xu Ying , He Jianbing , Ji Jie , Xu Shifa
Published: May 2018

Accurate determination of pavement service life based on time-series pavement condition data is crucial to achieve many pavement maintenance and management objectives. Although pavement condition monitoring frequency is one of the most important influencing factors used to estimate pavement service life, previous studies and applications are mainly focused on different monitoring frequencies with equal time intervals. No studies investigating the effect of pavement monitoring frequency with unequal time intervals for the determination of pavement service life have been conducted. In this study, the effects of estimating pavement service life using two pavement condition monitoring methods (equal versus unequal time intervals) under the same monitoring frequency were investigated. Two potential influencing factors, i.e., estimation methods (trend interpolation and extrapolation) and R2 of the fitted performance curve, were considered in this study. The analysis results indicate that, compared to the equal interval monitoring method at the same monitoring frequency, especially for pavement sections using the trend extrapolation method, the estimated accuracy of pavement service life was significantly improved using the unequal interval monitoring method. According to the analysis results, an optimal pavement condition monitoring method was developed and validated based on unequal interval monitoring using actual pavement condition data of I-16 in Georgia.
ZDDP Containing Tribofilms Generated under Sliding Micro Contact and Bearing Test Rig Conditions
Authors: Pape Florian , Muhmann Christian , Pahl David , Lipinsky Dieter , Arlinghaus Heinrich F. , Poll Gerhard
Published: May 2018

For machine elements in relative motion (like bearings), lubrication is mandatory to prevent wear or premature fatigue and to reduce friction. Oils and greases typically contain additives to protect against wear and oxidation by building up a tribofilm with a thickness of a few ten nanometers. There is the suspicion that under some critical compositions and under specific test conditions, the resulting tribofilm can cause early bearing failure because of subsurface damages like white etching cracks (WECs). One component relevant for tribofilm formation is zinc dialkyldithiophosphate (ZDDP), which forms protective phosphate glass-based tribofilms. With the aim of detecting critical lubricant compositions and test parameters, experiments on an FE8 test rig were performed. To investigate the formation of tribofilms, tests were also executed using a modified Center for Tribology (CETR, now Bruker Corporation, Billerica, MA) Olympus HDI reliability spin-stand. This device was originally developed to investigate the head-to-disk interface of a hard disk drive (HDD). During the test cycles, the coefficient of friction was recorded. In order to determine the effect of the operation conditions, the microtribological properties of the boundary layers were analyzed. The boundary layers were investigated by means of nanoindentations and nanoscratches on the raceways. Additionally, time-of-flight-secondary ion mass spectrometry (ToF-SIMS) with depth profiling was used to analyze the adhering lubricant, as well as the composition of the boundary layers.
Characterization of an activating R1353H insulin-like growth factor 1 receptor variant in a male with extreme tall height
Authors: Lin Yingbo , van Duyvenvoorde Hermine A , Liu Hongyu , Yang Chen , Warsito Dudi , Yin Chang , Kant Sarina G , Haglund Felix , Wit Jan M , Larsson Olle
Published: May 2018

Objective

The insulin-like growth factor1 receptor (IGF1R) is important in growth and development, and inactivating IGF1R mutations cause short stature and relatively high levels of serum IGF-I. We identified an unclassified IGF1RR1353H variant in a male with extreme tall height, very low levels of serum IGF-I and delayed and prolonged growth spurt. The index case’s mother and three sons all carried the variant, but so far only the eldest son (age 18 years) presented with tall height. We hypothesized that the variant could constitute an activating mutation.

Design

The IGF1RR1353H variant was investigated in Igf1r−/− mouse embryonic fibroblasts (R-cells) by cell cycle, colony formation and transcriptome analyses.

Results

The IGF1RR1353H (R-1353) exhibited significantly increased cell proliferation, G1-S progression and colony formation in soft agar. RNA sequencing identified 195 differentially expressed genes between R-WT and R-1353 (adjusted P < 1E-100). Most genes were upregulated in R-1353, including the gene encoding the androgen receptor (AR). Gene expression profiling showed the most significant enrichment in extracellular matrix organization (P = 2.76E-7), collagen biosynthesis (P = 1.21E-5) and cell adhesion (P = 7.38E-5). Retrospective biochemical analysis of the index case revealed decreased testosterone and sex hormone-binding globulin levels, whereas LH and FSH were within normal ranges. This profile suggests an increased sensitivity to androgen, which is compatible with the enhanced expression of Ar in R-1353 cells.

Conclusions

Our findings suggest that R1353H constitutes an activating IGF1R variant. The possible deregulation of collagen turnover and increased androgen sensitivity implicates an association to tall phenotype in male carriers.
Metformin counteracts the effects of FSH on rat Sertoli cell proliferation
Authors: Rindone Gustavo Marcelo , Gorga Agostina , Regueira Mariana , Pellizzari Eliana Herminia , Cigorraga Selva Beatriz , Galardo María Noel , Meroni Silvina Beatriz , Riera María Fernanda
Published: May 2018

Metformin (MET) is one of the most widely used anti-hyperglycemic agents for treating patients with type 2 diabetes and it has started to be used in pediatric population at ages when Sertoli cells are still proliferating. It is well known that follicle-stimulating hormone (FSH) is the major Sertoli cell mitogen. The aim of the study is to investigate a possible effect of MET, which has been shown to have anti-proliferative properties, on FSH regulation of postnatal Sertoli cell proliferation and on the molecular mechanisms involved in this regulation. The present study was performed in eight-day-old rat Sertoli cell cultures. The results obtained show that MET in the presence of FSH increases phosphorylated acetyl-CoA carboxylase and decreases phosphorylated p70S6K levels. Moreover, we show that MET decreases FSH-stimulated Sertoli cell proliferation, and this decrease is accompanied by a reduction in FSH-stimulated Ccnd1 and Ccnd2 expression and an increase in cell cycle inhibitor p21Cip expression. Altogether, these results suggest that MET can, at least in part, counteract the effect of FSH on postnatal Sertoli cell proliferation.
BLAST-XYPlot Viewer: A Tool for Performing BLAST in Whole-Genome Sequenced Bacteria/Archaea and Visualize Whole Results Simultaneously
Authors: Pedraza-Pérez Yagul , Cuevas-Vede Rodrigo Alberto , Canto-Gómez Ángel Bernardo , López-Pliego Liliana , Gutiérrez-Ríos Rosa María , Hernández-Lucas Ismael , Rubín-Linares Gustavo , Martínez-Laguna Ygnacio , López-Olguín Jesús Francisco , Fuentes-Ramírez Luis Ernesto
Published: May 2018

One of the most commonly used tools to compare protein or DNA sequences against databases is BLAST. We introduce a web tool that allows the performance of BLAST-searches of protein/DNA sequences in whole-genome sequenced bacteria/archaea, and displays a large amount of BLAST-results simultaneously. The circular bacterial replicons are projected as horizontal lines with fixed length of 360, representing the degrees of a circle. A coordinate system is created with length of the replicon along the x-axis and the number of replicon used on the y-axis. When a query sequence matches with a gene/protein of a particular replicon, the BLAST-results are depicted as an “x,y” position in a specially adapted plot. This tool allows the visualization of the results from the whole data to a particular gene/protein in real time with low computational resources.
Digital Transformation in Service Management
Authors: Matzner Martin , Büttgen Marion , Demirkan Haluk , Spohrer Jim , Alter Steven , Fritzsche Albrecht , Ng Irene C. L. , Jonas Julia M. , Martinez Veronica , Möslein Kathrin M. , Neely Andy
Published: May 2018

The digital transformation of single companies and of entire service businesses is an omnipresent topic – not only in the academic discourse but also in the current public debate. The topic is often approached phenomenologically. We invited a group of well-renown scholars from different academic fields to share with us personal observations and interpretations of the digital transformation in service management in the form of individual commentaries that go beyond. The commentaries we received are based on different theoretical perspectives. They include motivations of why digital transformation makes service management research (smr) more relevant, they depict implications for service companies, and they outline research needs. This article conflates the submitted commentaries, and it is the first SMR special research paper – a paper type that will be continued in future issues to explore topics in a similar fashion that are likely to have a significant influence on the development of smr.
Fibrosarcoma of Mandible Presenting As Secondary Primary Tumour - A Cytological Diagnosis
Authors: Sulagna Manna , Kalyani Raju , Azeem Mohiyuddin
Published: May 2018

Fibrosarcoma of bone occur in any location but mainly affects long bone. Its occurrence in craniofacial region is about 15%, mandible being the most common site. Fibrosarcoma of hed and neck area represents 5% of all malignant intraosseous tumours. It is commonly seen between 3rdto 6thdecades of life. Here we present a case in 65 years old female with past history of radiotherapy for carcinoma of buccal mucosa and now presents with fibrosarcoma of the left jaw which was diagnosed by FNAC and confirmed by biopsy.
Short-term Seizure Outcomes in Childhood Epilepsy
Authors: Aaberg Kari Modalsli , Bakken Inger Johanne , Lossius Morten I. , Lund Søraas Camilla , Tallur Kamath K. , Stoltenberg Camilla , Chin Richard , Surén Pål
Published: May 2018

BACKGROUND AND OBJECTIVES:

Seizure freedom is the optimal response to antiepileptic treatment. In previous studies, it has been shown that between 61% and 71% of children with epilepsy achieve seizure freedom, whereas 7% to 20% have drug-resistant epilepsy. The definition of drug resistance has not been consistent across studies, and there is a lack of contemporary population-based data. We used data from a large nationwide child cohort to provide such information, implementing the current standard definition of drug resistance.

METHODS:

The study was based on the Norwegian Mother and Child Cohort Study. Potential epilepsy cases were identified through registry linkages and parental questionnaires. Medical record reviews and parental interviews were used to collect clinical information and to classify seizures, epilepsies, and etiologies.

RESULTS:

The cohort included 112 745 eligible children aged 3 to 13 years (median age 7 years) at end of follow-up. Of these, 600 were epilepsy cases with at least 1 year of follow-up since epilepsy onset (median follow-up time: 5.8 years). There were 178 (30%) who had developed drug-resistant epilepsy, 353 (59%) who had been seizure free for ≥1 year, and 69 (12%) with intermediate seizure outcomes. Having an identified cause of epilepsy (genetic, structural, metabolic, or infectious) was associated with unsatisfactory seizure outcome (48% drug resistance) and influenced the relative risk associated with other prognostic factors. Sociodemographic characteristics were not associated with short-term seizure outcomes.

CONCLUSIONS:

Drug resistance occurs in 3 out of 10 children with epilepsy, whereas 6 out of 10 become seizure free. Having an identified cause of epilepsy is associated with poor response to treatment.
ОСОБЛИВОСТІ ОТРИМАННЯ АСЕПТИЧНОЇ КУЛЬТУРИ ACER SACCHARINUM L. В УМОВАХ IN VITRO
Authors: Bilous S.Yu. , Kurdyuk O.M. , Medvedchuk O.V.
Published: May 2018

Обґрунтовано актуальність мікроклонального розмноження Acer saccharinum L. Наведено особливості морфогенезу при введенні в культуру in vitro Acer saccharinum L. Проведено підбір оптимального часу відбору та тип експлантів. Встановлено оптимальні концентрації стерилянтів і час експозиції для ефективного (95 %) отримання асептичної культури Acer saccharinum L. Підібрано основні компоненти живильного середовища з додаванням регуляторів росту цитокінінового типу дії. Встановлено найефективніше середовище з додаванням 0,2 мг∙л-1 тідіазурону для успішного отримання морфогенно активних мікропагонів клена сріблястого в умовах in vitro.
СОБІВАРТІСТЬ ВИРОЩУВАННЯ ПІДЩЕП ДЛЯ ДЕКОРАТИВНИХ ФОРМ MORUS ALBA L.
Authors: Vitenko V.A.
Published: May 2018

Здійснені багаторічні дослідження з вирощування насіннєвих та вегетативних (укорінених зелених і здерев'янілих живців) щеп для декоративного формового різноманіття Morus alba L. дали змогу визначити собівартість їх вирощування та порівняти показники рентабельності. Встановлено, що найефективнішим способом вирощування підщепного матеріалу Morus alba L. є її укорінення здерев'янілими живцями у ранньоосінній період. Особливу увагу при цьому потрібно приділяти заготовленню живців, які потрібно заготовляти із молодих рослин, які не вступили у фазу плодоношення.З'ясовано, що найбільш довготривалим є вирощування насіннєвих підщеп, що можна пояснити більш тривалим ростом підземної та надземної частин підщеп у перші два роки.
РІСТ ТА ПРОДУКТИВНІСТЬ ЕКСПЕРИМЕНТАЛЬНИХ КУЛЬТУР СОСНИ ЗВИЧАЙНОЇ З РІЗНОЮ ГУСТОТОЮ
Authors: Zhukovskyi O.V.
Published: May 2018

Представлено результати вивчення впливу густоти деревостану на основні таксаційні показники 38-річних культур сосни звичайної. У процесі проведених досліджень встановлено, що середній діаметр деревостанів на секціях з різною їх густотою відрізняється від контролю на 5-10 %, а середня висота – на  5-8 %. Найбільшу різницю простежено у запасах деревостанів і становить 9-18 % між секціями і контролем. Зроблено висновок, що задана в молодому віці густота деревостану зберігає значний вплив на таксаційні показники через 38 років. Матеріали досліджень свідчать, що стояння дерев із густотою 4000 шт.·га-1, незалежно від способу рубки догляду, є оптимальним для отримання високого запасу деревини.
СУЧАСНИЙ СТАН ДЕРЕВНО-ЧАГАРНИКОВИХ НАСАДЖЕНЬ ДЕНДРОПАРКУ МЕЛІТОПОЛЬСЬКОГО ДЕРЖАВНОГО ЕДАГОГІЧНОГО УНІВЕРСИТЕТУ ІМЕНІ БОГДАНА ХМЕЛЬНИЦЬКОГО
Authors: Maltseva S.Yu. , Solonenko А.M. , Maltsev Ye.I.
Published: May 2018

Представлено матеріали щодо систематичної та екологічної структури деревно-чагарникової рослинності дендропарку Мелітопольського державного педагогічного університету імені Богдана Хмельницького. У складі дендрофлори дендропарку виявлено 60 видів дерев і чагарників, які представляють 52 роди, 4 класи, 24 порядки і 30 родин з відділів Pinophyta та Magnoliophyta. Серед представників дендрофлори є рідкісні, зникаючі, реліктові види та види, що охороняються (Ginkgo biloba L., Taxus baccata L., Ephedra arborea Lag., Paeonia suffruticosa Andr., Aralia mandshurica Rupr. et Maxim., Hibiscus syriacus L. та ін.) Частка інтродукованих представників становить 70 %. З екологічного погляду, переважають ксерофіти і ксеромезофіти.
АНАЛІЗ ДОСВІДУ АНАЕРОБНОГО ЗБРОДЖУВАННЯ ОСАДІВ СТІЧНИХ ВОД У КОНТЕКСТІ ЙОГО ЗАСТОСУВАННЯ НА ЛЬВІВСЬКИХ КАНАЛІЗАЦІЙНИХ ОЧИСНИХ СПОРУДАХ
Authors: Zhuk V.M. , Popadyuk I.Yu. , Verbovsky O.V.
Published: May 2018

Наведено аналіз перспектив будівництва метантенків на Львівських каналізаційних очисних спорудах згідно з проектом, виконаним шведською компанією "Абанор АБ". Проаналізовано закладені в проекті технічні показники та виконано їх порівняння зі сучасними аналогами. Окреслено ризики реалізації проекту з урахуванням місцевих умов. Для перевірки ефективності процесу термофільного анаеробного зброджування осадів стічних вод на Львівських КОС запропоновано виконати натурні експериментальні дослідження на пілотній установці – фізичній моделі метантенка.
ДОСЛІДЖЕННЯ ВПЛИВУ ВОДИ РІЗНОЇ ТВЕРДОСТІ НА КРОВ ЛЮДИНИ
Authors: Matsiyevska O.О.
Published: May 2018

Досліджено вплив води різної твердості на стан крові людини. Під час серій експериментів досліджуваний випивав дистильовану, водопровідну, талу та мінеральну природну натрієву гідрокарбонатну борну лікувально-столову воду "Поляна Квасова". Стан крові визначено скануванням за допомогою цифрового фазово-контрастного мікроскопа та порівняно з еталонним. Стан крові, близький до ідеального, зафіксовано за споживання людиною мінеральної води "Поляна Квасова". З усіх досліджених зразків "Поляна Квасова" характеризується найбільшою твердістю.
ОТРИМАННЯ РОЗРІДЖЕНОЇ МАСИ З РІЗНИХ ЗЛАКОВИХ ІЗ ВИКОРИСТАННЯМ ФЕРМЕНТНОГО ПРЕПАРАТУ FILTRASE BRX
Authors: Melnyk S.R. , Shevchuk L.I. , Melnyk Yu.R. , Boychuk O.L.
Published: May 2018

Наведено результати дослідження впливу ферментного препарату Filtrase BRX на закономірності отримання розрідженої маси з різних зернових культур: ячменю, вівса і пшениці. Визначено вплив ферментного препарату Filtrase BRX на в'язкість розрідженої маси, приготованої зі зазначених зернових культур за співвідношень зерно: вода – 1: (3-10). Показано, що використання Filtrase BRX сумісно із ферментним препаратом Amilex 4T, насамперед, впливає на зменшення кінематичної в'язкості розрідженої маси і, меншою мірою, – на зміну вмісту сухих речовин. Встановлено, що застосування ферментного препарату Filtrase BRX дає змогу зменшити витрату електроенергії в одному апараті термоферментативного оброблення у разі розрідження замісу з вівса на 29,8 %, а в разі розрідження замісу з ячменю – на 12,1 %.
МАТЕМАТИЧНА МОДЕЛЬ РОБОТИ АДГЕЗІЇ ОЛІЙНИХ КОМПОЗИЦІЙ НА ДЕРЕВИНІ
Authors: Yaremchuk L.A. , Pobereyko B.P.
Published: May 2018

Наведено математичну модель для дослідження роботи адгезії олійних композицій на деревинній підкладці. Теоретично визначено час розтікання олійної композиції на деревині. Задано граничні умови термодинамічних параметрів, які описують взаємозв'язок деревини (тверде тіло) з олійною композицією (рідина) на основі закону Гіббса для побудови математичної моделі роботи адгезії. Визначено вплив термодинамічних властивостей деревини та олійної композиції на крайовий кут змочування поверхні. Отримано залежність часу розтікання олійної композиції по поверхні деревини.
ІНТЕЛЕКТУАЛЬНА ПІДТРИМКА ПРИЙНЯТТЯ РІШЕНЬ В УМОВАХ НЕВИЗНАЧЕНОСТІ ПІД ЧАС КЕРУВАННЯ ОБ'ЄКТАМИ ПРИРОДОКОРИСТУВАННЯ
Authors: Shufnarovych M.A.
Published: May 2018

Актуальним питанням на сьогодні залишається збереження екологічно чистих територій, а також не менш важливим є питання прогнозування повеней і паводків на території України. Для вирішення цього питання запропоновано метод моделювання стану ґрунтів, шляхом застосування штучних нейронних мереж, а також система інтелектуальної підтримки прийняття рішень за результатами прогнозування рівня води в річках. В основу комп'ютерної системи покладено спеціалізоване програмне забезпечення, що ґрунтується на методі побудови математичних моделей на принципах генетичних алгоритмів. Використання ідей генетичних алгоритмів до побудови математичних моделей дає змогу не тільки вибрати оптимальну за структурою адекватну модель, але й значно зменшити число обчислень під час перебору моделей.
ЕКОЛОГІЗАЦІЯ ОСВІТИ ЯК КЛЮЧОВИЙ ФАКТОР ПІДГОТОВКИ ФАХІВЦІВ ДЛЯ СТАЛОГО РОЗВИТКУ
Authors: Tunytsya Yu.Yu. , Adamovsky M.G. , Borys M.M. , Kraievskyi S.N. , Magazynshchykova I.P.
Published: May 2018

Розглянуто сутність та сучасні проблеми екологізації вищої освіти в контексті вимог найновіших життєво важливих міжнародних документів – Паризької угоди Сторін Рамкової конвенції ООН щодо змін клімату (грудень 2015 р.); "Порядку денного для сталого розвитку до 2030 року", прийнятого на саміті ООН з Розвитку (вересень 2015 р.); "Платформи для дій "Освіта-2030", прийнятої на 38-й сесії Генеральної конференції ЮНЕСКО (листопад 2015 р.); добровільних зобов'язань України щодо екологізації освіти (Greening of Education: Ukraine's Contribution), взятих на саміті ООН "Ріо+20" (червень 2012 р.), а також Рішення колегії МОН України від 27 листопада 2015 р. "Про екологізацію вищої освіти України з метою підготовки фахівців для сталого розвитку". Окреслено здобутки вищих навчальних закладів України, зокрема Національного лісотехнічного університету України, у царині екологізації освіти як ключового фактора високопрофесійного кадрового забезпечення сталого розвитку.
ДЕНДРОФЛОРА БАЛКИ ШИРОКА (ОСТРІВ ХОРТИЦЯ)
Authors: Yakovlieva-Nosar' S. O. , Bessonova V. P.
Published: May 2018

Байрачні ліси Запорізької обл. відносять до байраків порожистої частини Дніпра. Вони мають важливе кліматичне та ґрунтозахисне значення, у них трапляються представники лісових, степових, лугових фітоценозів, часто – рідкісні й ендемічні види, а також місцева фауна. Такі заліснені балки характеризуються високою атракторною здатністю для рекреантів, діяльність яких призводить до трансформації рослинності байрачно-лісових фітоценозів. З огляду на це актуальною є інформація про стан їх дендрофлори для створення банку даних та оперативного моніторингу. Наведено дані про видовий склад дендрофлори балки Широка, розташованої на о. Хортиця (зона рекреаційної діяльності туристів та мешканців м. Запоріжжя), де зареєстровано 54 види деревних рослин, що належать до 43 родів і 26 родин. Встановлено, що найбільшим видовим насиченням характеризується родина Rosaceae Adans. У складі дендрофлори байрачного лісу аборигенні види становлять 48,1 %, інтродуковані – 51,9 %. Найбільша частка участі серед інтродукованих видів належить породам північноамериканського походження (11 видів, або 39,3 % від усієї кількості інтродуцентів). Інтродуценти представлені здебільшого Amorpha fruticosa, Robinia pseudoacacia, Morus alba та Celtis occidentalis. Основними лісотвірними аборигенними породами насадження є Acer platanoides, Quercus robur, Ulmus scabra, A. tataricum. З'ясовано породний склад верхніх ярусів деревостану та підліску, що зростають на території різних морфологічних частин балки. Байрачний ліс має значний ресурсний потенціал, включаючи медоносні та вітамінні рослини. У складі насадження виявлено види з високою інвазійною здатністю (Acer negundo, Amorpha fruticosa, Robinia pseudoacacia) та той, що визнано інвазійним у списках близьких до України територій (Parthenocіssus quinquifolia).
ХАРАКТЕРИСТИКА ВОЛЬЄРІВ ДЛЯ РАТИЧНИХ ARTIODACTYLA НА ТЕРИТОРІЇ ЖИТОМИРСЬКОЇ ОБЛАСТІ
Authors: Kratiuk O. L. , Guziy A. I. , Vlasiuk V. P. , Bezditko L. V.
Published: May 2018

Досліджено стан вольєрного господарства Житомирської області. На 01.03.2018 р. на території області мисливське господарство веде 91 користувач, в 11 з них функціонують вольєри. Їх загальна площа становить 941,7 га. Порівняно з 2007 р. площа вольєрів зросла у 8 разів. Найбільшими у регіоні є вольєри ТОВ "Камія Плюс" (500,0 га) та СФГ "Земля Полісся" (228,0 га). Серед державних підприємств найбільші вольєри функціонують у ДП "Білокоровицьке ЛГ" (70,5 га) та ДП "Баранівське ЛМГ" (56,2 га). Ще три вольєри можна вважати (для Житомирської обл.) середніми, а саме: вольєр ТОВ "МК "Хантер" (40,0 га), ТОВ "УТМР" (29,0 га) та Житомирської ОО УТМР (12,0 га). Упродовж 2007–2017 рр. загальна площа вольєрів області істотно зросла. У 2007 р. вона становила 120,0 га, а на початок 2018 р. – 941,7 га. Завдяки будівництву у 2011 р. вольєра ТОВ "Камія Плюс" їх площа зросла більш ніж удвічі. На початку ХХІ ст. на території області існувало 4 вольєри (ДП "Баранівське ЛМГ", ДП "Радомишльське ЛМГ", СФГ "Земля Полісся" та МГ "В'юнки"), в яких утримували 46 особин Cervus nippon та 75 особин Sus scrofa. У 2017 р. чисельність основного поголів'я ратичних становила уже 561 особину 6 видів (Cervus elaphus (29,6 %), Sus scrofa (20,0 %), Dama dama (19,3 %), Ovis ammon (18,2 %), Cervus nippon (8,2 %), Capreolus capreolus (4,8 %)). Якщо у 2013 р. більше половини всього поголів'я (52,4 %) становила Sus scrofa, то за два роки – у 2016 р. – її частка становила вже 40,0 %, а у 2018 р. – тільки 20,0 %. Натомість частка Cervus elaphus за останні три роки у вольєрах зросла від 15,3 % до 29,6 %.