bluuebunny/crossref_metadata_2025 huggingface dataset:
Lithium Cholesterol Sulfate: A Novel and Potential Drug for Treating Alzheimer’s Disease and Autism Spectrum Disorder
Authors: Hu Weiqiang , Zhao Menghua , Lian Junrong , Li Dandan , Wen Jinhua , Tan Jun
Published: August 2022

Background and Objective:

Recent studies have shown that lithium treatment can reduce symptoms of Alzheimer’s disease (AD) and Autism Spectrum Disorder (ASD). However, the present lithium salts clinically available have serious short-term and long-term side effects, requiring frequent monitoring of blood chemistry and plasma lithium levels to avoid toxicity. Consequently, there is a demand for a safer and more effective lithium formulation to treat these diseases.

Methods:

Hence, we firstly synthesized lithium cholesterol sulfate (LiCS) and compared its pharmacological effects with that of lithium chloride (LiCl) and sodium cholesterol sulfate (NaCS) on markers of neurodegenerative disease in cell cultures.

Results:

LiCS was more potent than LiCl in increasing inhibitory GSK3β (Ser9) phosphorylation (pGSK3β) in both CHO and SH-SY5Y cells. These agents dose-dependently increased pGSK3β, starting at 10 μM for LiCS and 60 μM for LiCl and maximally by approximately 100% at 60 μM for LiCS and 1.25 mM for LiCl, without altering total GSK3β levels. In HEK293/tau cells, LiCS reduced tau (Thr231) phosphorylation (ptau) starting at 10 μM and maximally by 63% at 40 μM without altering total tau levels, but ptau levels were not altered by LiCl at any dose between 60 μM and 1.25 mM. In BV2 cells, LiCS and LiCl decreased LPS-induced TNFα levels, starting at 20 μM for LiCS and 5 mM for LiCl, and maximally by approximately 30% at 80 μM for LiCS and 20 mM for LiCl. NaCS at any dose between 5 and 90 μM did not alter pGSK3β, ptau or LPS-induced TNFα.

Conclusion:

LiCS may become a new drug with good pharmacological potential for the treatment of neurodegenerative disorders, such as AD and ASD, by allowing lithium to more readily access intracellular pathological processes.
Natural Carbohydrates-based Nanoparticles: A Review of Pharmaceutical
Applications
Authors: Kumar Karan , Wadhwa Sheetu , Sharma Arun , Singh Gurvinder , Kumar Rajesh
Published: August 2022

Carbohydrates are the most common biopolymers with the capability to construct supramolecular structures. For biomedical purposes, a variety of carbohydrate-based nanoparticles have been
used. Basic monosaccharides or disaccharides, along with sophisticated polymeric systems, are used to
create these structures. The shape and properties of these materials can be modified using chemical
alterations. Carbohydrates-based nanogels and nanoparticles have been used for drug delivery, tissue
engineering, and cell imaging. Carbohydrate-based elements are excellent derivatives for the production of responsive systems because of the reversible character of the assembly, which is frequently
based on a mixture of hydrophobic interactions and hydrogen bonding. The present manuscript attempts to review the recent studies on carbohydrate-based nanomaterials and an update on the patents
granted for the same.
MicroRNA-16 Represses TGF-β1-induced Epithelial-to-Mesenchymal
Transition in Human Lung Adenocarcinoma Cell Line
Authors: Rajasekaran Subbiah , Mishra Sehal , Gandhi Deepa
Published: August 2022

Background:

The transforming growth factor-beta1 (TGF-β1)-induced epithelial-tomesenchymal
transition (EMT) has a crucial effect on the progression and metastasis of lung cancer
cells.

Objective:

The purpose of this study was to investigate whether microRNA (miR)-16 can suppress
TGF-β1-induced EMT and proliferation in human lung adenocarcinoma cell line (A549).

Methods:

Quantitative real-time polymerase chain reaction (RT-qPCR) was used to detect the expression
of miR-16. The hallmarks of EMT were assessed by RT-qPCR, Western blotting, and cell proliferation
assay. A bioinformatics tool was used to identify the putative target of miR-16. The activation of
TGF-β1/Smad3 signaling was analysed using Western blotting.

Results:

Our results showed that miR-16 expression was significantly down-regulated by TGF-β1 in
A549 cells. Moreover, agomir of miR-16 suppressed TGF-β1-induced EMT and cell proliferation.
Computational algorithms predicted that the 3’-untranslated regions (3’-UTRs) of Smad3 are direct targets
of miR-16. In addition, miR-16 mimic was found to inhibit the TGF-β1-induced activation of the
TGF-β1/Smad3 pathway, suggesting that miR-16 may function partly through regulating Smad3.

Conclusion:

Our results demonstrated that overexpression of miR-16 suppressed the expression and activation
of Smad3, and ultimately inhibited TGF-β1-induced EMT and proliferation in A549 cells. The
present findings support further investigation of the anti-cancer effect of miR-16 in animal models of
lung cancer to validate the therapeutic potential.
Are Herbal-peptides Effective as Adjunctive Therapy in Coronavirus
Disease COVID-19?
Authors: Rafieian-Kopaei Mahmoud , Aleebrahim-Dehkordi Elahe , Soveyzi Faezeh , Saberianpour Shirin
Published: August 2022

Background:

Plant antiviral peptides (AVP) are macromolecules that can inhibit the
pathogenesis of viruses by affecting their pathogenic mechanism, but most of these peptides can
bind to cell membranes, inhibit viral receptors, and prevent viruses. Recently, due to the
coronavirus pandemic, the availability of appropriate drugs with low side effects is needed. In this
article, the importance of plant peptides in viral inhibition, especially viral inhibition of the
coronavirus family, will be discussed.

Methods:

By searching the databases of PubMed, Scopus, Web of Science, the latest articles on
plant peptides effective on the COVID-19 virus were collected and reviewed.

Results:

Some proteins can act against the COVID-19 virus by blocking sensitive receptors in
COVID-19, such as angiotensin-converting enzyme 2 (ACE2). The 23bp sequence of the ACE2
alpha receptor chain can be considered as a target for therapeutic peptides. Protease and RNAP
inhibitors and other important receptors that are active against COVID-19 should also be
considered.

Conclusion:

Herbal medicines with AVP, especially those with a long history of antiviral effects,
might be a good choice in complement therapy against the COVID-19 virus.
Robust and Lightweight System for Gait-based Age Estimation towards
Viewing Angle Variations
Authors: Upadhyay Jaychand , Gonsalves Tad , Katkar Vijay
Published: August 2022

Gait based age recognition is a very challenging task, as it involves multiple hurdles such as change in viewpoint of the person. The proposed system handles this problem by performing a sequence of tasks such as GEI formation from silhouette, applying DCT on GEI and extracting the features and finally using MLP for age estimation. The proposed system proves its effectiveness comparing the performance with state of art methods -conventional methods and deep learning based methods. The performance of the system is estimated on OU-MVLP and OULP-Age datasets. The experimental results show the robustness of the system against viewing angle variations.

Background:

In computer vision applications, gait-based age estimation across several cameras is critical, especially when following the same person in various viewpoints.

Objective:

To implement the system which adopts lightweight approach for gait-based age estimation.

Method:

The proposed system uses a combination of the discrete cosine transform (DCT) and multi-layer perceptron (MLP) on gait energy image (GEI) to perform age estimation.

Result:

The performance of the system is extensively evaluated on the OU-MVLP and OULP-Age datasets.

Conclusion:

The proposed system attains best mean absolute error (MAE) of 5.05 (in years) for the OU-MVLP dataset, and 5.65 for the OULP dataset.
GENERA-Z TANGGUH; GEN-Z OF PRIMAGANDA JOMBANG HIGH SCHOOL EMPOWERMENT TOWARDS HANDLING OF COVID-19 IN THE SCHOOL WITH PREVENTIVE AND 4T (TRACING, TEXTING, TESTING, TREATMENT) EFFORT
Authors:   Department of Nursing, Faculty of Health Science, Universitas Brawijaya, Susanto Akhiyan Hadi , Micho Rahma ,   Department of Nutrition, Faculty of Health Science, Universitas Brawijaya, Wisnasari Shila , Azizah Nurona , Ariningpraja Rustiana Tasya ,   Department of Nursing, Faculty of Health Science, Universitas Brawijaya
Published: August 2022

The government has started to require limited face-to-face learning starting in July 2021. Until now, cases of Covid-19 transmission are still being reported. Primaganda High School, Jombang is one of the high schools in Jombang within the Pondok Pesantren environment with moderate exposure to Covid-19 transmission. The risk of transmission during face-to-face learning will be quite high, so there is a need for an integrated management of COVID-19 handling based on proper human resource empowerment. The purpose of community service is to increase empowerment through training. The integrated training was provided for 2 months involving 46 students (referred to as “Genera-Z Tangguh”) as initial movers. Empowerment focuses on preventing the transmission of Covid-19 (education and application of health protocols), and 4T (tracing, texting, testing, treatment) by utilizing digital applications. Activity results include, 1) An increase in the knowledge of Tangguh Genera-Z members about the application of health protocols in schools with an average score of 90 (pre-test mean 30), 2) An increase in knowledge of Tangguh Genera-Z members about 4T cases of Covid-19 with an average post-test score of 70 (pre-test mean 30), 3) The establishment of an integrated Covid-19 handling system related to reporting management and handling of related parties at Primaganda High School Jombang. It can be concluded that this activity is one of the important student social activities and needs to be an example for its application in other schools, to prevent the spread of Covid-19 in the school environment.
COMMUNITY EMPOWERMENT FOR PREVENTION AND SCREENING OF COVID-19 COMORBID DISEASE IN AYAPO VILLAGE
Authors:   Nursing Diploma Study Program, Health Polytechnic of Ministry of Health Jayapura, Apay Frengky , Kusuma Ardhanari Hendra ,   Applied Nursing Undergraduate Study Program, Health Polytechnic of Ministry of Health Jayapura, Rohmani Rohmani ,   Nurse Profession Study Program, Health Polytechnic of Ministry of Health Jayapura
Published: August 2022

Public awareness in facing the Corona Virus Disease-19 (Covid-19) pandemic is decreasing, many are neglecting the use of masks, keeping a safe distance of 1-2 meters, washing hands with soap and the use of hand sanitizers has also decreased. This shows that the fact that the incidence of covid-19 cases is increasing. The surge in Covid-19 patients is still not under control by many countries, but some of them have experienced a decline. After almost recording 100,000 new Covid-19 patients in a day. Awareness in preventing covid-19 by implementing public health protocols is decreasing. Therefore, it is necessary to have the involvement of village community leaders, religious leaders, youth leaders, women leaders, youth coral cadets, heads of community health centers and local governments to make the village community aware. We will form a covid-19 task force team in Ayapo Village. The examination of Comorbid Diseases by screening blood pressure measurements, measuring cholesterol levels, and measuring uric acid levels in adult patients in Ayapo Village The purpose of this community service is to prevent the spread of Corona virus disease-19 in Ayapo Village. This community service method is with a quantitative approach by providing health counseling to the community, screening for comorbid corona virus disease-19. The results showed that the knowledge of the people of Ayapo village about Corona virus disease- 19 was most dominant knowledge with a total of 58 people (81.7%) and the least was good knowledge totaling 2 people (2.8%). Conclusion: Community knowledge and public awareness in preventing covid-19 in Ayapo Village are still lacking.
INCREASING CLINICAL PRECEPTOR COMPETENCE THROUGH PRECEPTORSHIP METHOD TRAINING IN BANGIL HOSPITAL, PASURUAN REGENCY
Authors:   Department of Nursing, Faculty of Health Sciences, Universitas Brawijaya, Amaliya Sholihatul , Kapti Rinik Eko , Choiriyah Muladefi , Sari Efris Kartika , Ulya Ikhda , Rini Ika Setyo ,   Department of Nursing, Faculty of Health Sciences, Universitas Brawijaya
Published: August 2022

The Preceptorship method facilitates students to develop their cognitive, affective, and psychomotor abilities. Through Preceptorship, clinical instructors/preceptors become role models as tutors, leaders, supervisors, and mentors for students. Furthermore, nursing staff who meet the qualifications of a preceptor need Preceptorship training. The Pasuruan District Hospital is one of the network hospitals where nursing students practice the nursing profession, and there are only a few preceptors have attended Preceptorship training. Therefore, it is necessary to conduct Preceptorship training for preceptors. This activity aims to achieve preceptor competence with the Preceptorship method. The respondents were health care staff from Bangil Hospital, such as nurses, midwives, nutritionists, radiographers, medical recorders clerks, and physical therapists. The activity included training for three days from 19-21 November 2019 by providing material, demonstrating, and simulating the Preceptorship method in several rooms at Bangil Hospital. The data collection to measure the level of knowledge used pre-test and post-test questionnaires, while for skills using observation in the implementation of simulations directly to students in the hospital room. Forty-seven respondents participating in this training were male (32%) and female (68%). The results of the level of knowledge were pre-test mean 47.74 and post-test 88.85 with p-value paired t-test results 0.001. Observation results show that the preceptor can practice the Preceptorship method well with students. In conclusion, this training activity increases the knowledge and skills of Preceptorship clinical education methods for preceptors.
INCREASING EARLY DETECTION OF CHILDHOOD GROWTH DISORDERS WITH CHRONIC DISEASES IN COVID-19 ERA
Authors:   Allergy-Immunology Division, Pediatric Department, Faculty of Medicine, Universitas Brawijaya/dr. Saiful Anwar Hospital, Indonesia, Wulandari Desy , Barlianto Wisnu , Koentartiwi Dyahris , Wulandari Hajeng ,   Allergy-Immunology Division, Pediatric Department, Faculty of Medicine, Universitas Brawijaya/dr. Saiful Anwar Hospital, Indonesia
Published: August 2022

Impaired growth is still a problem that needs attention in Indonesia. There are still many incidents of children with short stature due to lack of nutrition, undernourished toddlers, and even malnutrition. Therefore, the detection of child growth still needs to be improved. The Covid-19 pandemic has made parents of patients afraid and anxious to take their children to health facilities, so that monitoring of their growth is neglected, especially in pediatric patients with chronic diseases. This community service activity is intended to provide training to parents of patients on how to measure anthropometric status in pediatric patients with chronic diseases so that parents are expected to be able to screen or detect growth disorders early and independently. Therefore, education and training are held with the aim of increasing the knowledge and skills of parents in examining the anthropometric status of children. Evaluation is done by asking questions and practicing anthropometric status checks at the beginning and end of the activity and good numbers of material uptake by participants are obtained so that participants can independently assess the child's anthropometric status and get an increase in skills. The knowledge of the patient's parents about awareness of growth and development screening is still lacking so that it can affect the detection of developmental disorders in children. With this activity, it can provide the ability of the patient's parents to equip themselves to monitor the growth of their child.
Hacia la restauración con Annona glabra (Annonaceae) de una selva inundable: establecimiento y crecimiento de plántulas, y cambio en la vegetación acompañante
Authors: Sánchez-García Edgar Abel , López Rosas Hugo , Sosa Vinicio J. , Lindig-Cisneros Roberto , Moreno-Casasola Patricia
Published: August 2022

Antecedentes y Objetivos: Actualmente existe deterioro y disminución de selvas inundables debido a la deforestación para ganadería e introducción de pastos exóticos. Los objetivos del presente estudio fueron evaluar el porcentaje de supervivencia de plántulas de Annona glabra, el cambio en la vegetación acompañante, y estimar los costos de los tratamientos experimentales de restauración ecológica de una selva inundable de A. glabra transformada en pastizal e invadida por el pasto exótico Echinochloa pyramidalis. Métodos: El estudio se realizó en un pastizal inundable en la costa central de Veracruz, México. Consistió en sembrar cuatro plántulas de A. glabra en cuadros experimentales expuestos a distintas técnicas de restauración. Se probaron 15 tratamientos experimentales que consistieron en cinco técnicas de restauración (sin modificación, cubierta plástica, plantación de Pontederia sagittata, remoción de suelo, y elevación del suelo) y tres pretratamientos aplicados a las plántulas sembradas (plántulas de vivero con y sin fertilizante, plántulas de selva) en un diseño de bloques al azar.Resultados clave: Se registró baja supervivencia de plántulas (30.7%), siendo mayor en plántulas de selva (41.1%). El mayor porcentaje de supervivencia se registró con la técnica de elevación del suelo, seguido de la de remoción. Se registraron 40 especies en la vegetación; la mayor riqueza específica se observó en las técnicas de elevación del nivel del suelo y remoción. Las especies con mayor Valor de Importancia Relativa fueron Echinochloa pyramidalis, Mimosa pigra y Annona glabra. El pretratamiento en el cual se obtuvieron las plántulas directamente de la selva fue el más económico.Conclusiones: Se requieren acciones para incrementar el éxito de la reforestación. Para futuros proyectos de restauración, recomendamos la elevación del suelo en áreas de transplante y cubierta de plástico previo a la plantación, para incrementar la probabilidad de supervivencia, y reducir la cobertura del pasto; además de la reforestación con plántulas colectadas de un fragmento de selva.
Results of numerical modelling of the problem of video pulse ground penetrating radar research in freshwater bodies
Authors: Gulevich Oxana , Volkomirskaya Liudmila , Mingalev Igor , Varenkov Vladimir , Suvorova Zoya , Akhmetov Oleg , Mingalev Oleg , Reznikov Aleksander
Published: August 2022

Ground-penetrating radar profiling on the surface of water bodies is applied in various geological and engineering studies. Here, we present the results of numerical simulation of the propagation of a video pulse electromagnetic signal in a freshwater body with gradients of the permittivity and electrical conductivity in the near-bottom layer. The method of numerical solutions of Maxwell's equations in the time domain is applied, in the general setting for rapidly changing processes, without restrictions on the magnitude of the change in the parameters of the medium. The results make it possible to explain the apparent decrease in water depth according to GPR data in comparison with the true depth and the appearance of additional reflecting boundaries on radargrams in the bottom layer.
Using Big Data Technology to Protect the Environment
Authors: Dovgal Vitaly , Kuizheva Saida
Published: August 2022

In the context of digitalization of all aspects of the surrounding world, data is becoming particularly relevant as one of the most valuable resources. The concept of "big data" means a huge amount of information, the size of which is too large, or it is created too quickly or has a structuring that does not allow it to be processed using traditional data management systems. Currently, large amounts of data and analytics are increasingly used by government agencies, non-governmental organizations and private companies in the field of environmental protection. The range of practical use of this technology is quite wide: from improving energy efficiency, tracking climate change over long periods of time, monitoring water quality, and ending with the promotion of environmental justice. This article describes several extremely promising applications of large data sets and their analytics, which can help achieve the goals of environmental protection and sustainable development, provide environmental benefits, help research on the environment, its conservation and protection. The widespread adoption of big data processing solutions allows us to illustrate the range of initiatives and approaches to reduce the environmental burden used by government agencies, non-governmental organizations and private companies.
Clinical and Antimicrobial profile of Acinetobacter Species at a Tertiary Care Teaching Hospital
Authors: Madhavi R. Bindu , Anitha D. , Beena P.M.
Published: August 2022

Acinetobacter infection with multidrug resistant strains is an emerging infection of global concern as it leads to serious disease. They are also important pathogens causing hospital acquired infections. Information on the prevalence, spectrum of illness and antibiotic sensitivity pattern of Acinetobacter is important for appropriate management of patients. We aimed to determine the prevalence of Acinetobacter species and evaluate the clinical profile and antibiotic sensitivity pattern of Acinetobacter species from various clinical samples. From October 2018 to September 2019, various clinical samples received in the microbiology laboratory were studied from the electronic records and the data on the isolation of Acinetobacter from these samples and its antibiotic sensitivity pattern was collected and analysed. The clinical data was also collected to determine the clinical spectrum. The prevalence of Acinetobacter species from various clinical samples was found to be 8.9%. Isolates were more common in general wards than in ICUs. The Acinetobacter infections occurred significantly in male patients (65.7%) than in female patients (34.3%), with male: female ratio of 1.9:1. The most common infection caused by Acinetobacter species was Wound infection (54.36%) followed by Respiratory tract infection (34.27%). Multidrug resistance was seen in 75 % of the isolates. Significant prevalence of multidrug resistant Acinetobacter infections was noted in our study. The findings emphasize the need for strict hospital infection control practices and the restricted use of antibiotics to prevent the occurrence of these infections.
Presence of Extended Spectrum Beta Lactamase, Virulence Genes and Resistance Determinants in Biofilm Forming Klebsiella pneumoniae Isolated from Food Sources: A Potent Risk to the Consumers
Authors: Ashwath Priyanka , C Bhavyashree , Gatty Ashwitha M. , M. Kavitha G. , Sannejal Akhila Dharnappa
Published: August 2022

Foodborne diseases and infection caused by associated pathogens is a public health concern. Majority of the investigations focus on common foodborne pathogens like Vibrio parahaemolyticus, Escherichia coli, Listeria monocytogenes, Shigella, Salmonella and Staphylococcus aureus. Limited knowledge has been accounted on Klebsiella pneumoniae. Presence of multidrug-resistant K. pneumoniae in the food supply is disturbing. Hence, this study assessed the presence of K. pneumoniae isolates from food samples (fresh vegetables and chicken), ascertained the presence of drug-resistant phenotypes, extended spectrum beta lactamase production, antibiotic resistance determinants, genes associated with virulence and their ability to form biofilm. Resistance towards ceftazidime and tetracycline was noted among all the isolates in the study, while they exhibited sensitivity to chloramphenicol and co-trimoxazole. All the isolates were potent ESBL producers carrying at least one ESBL encoding genes. Plasmid mediated quinolone resistance gene was detected in one isolate each from onion and chicken respectively. The isolates marked the absence of tetracycline and chloramphenicol resistance genes. Multiple virulence genes (ureA, khe, fimH, mrkD, wabG, uge and elt) were possessed by each of the isolates. K. pneumoniae from chicken and cucumber were moderate biofilm formers and those from tomato exhibited weak biofilm formation. Increased expression of the mrkA gene and reduction in the expression of the biofilm forming gene fimH gene was observed among the biofilm formers. One of the moderate and non-biofilm formers exhibited increased mrkD gene expression. The results from our study stipulate, that raw vegetables and meat serve as dormant source of drug-resistant and virulent K. pneumoniae.
Optimal Performance of Security by Fragmentation and Replication of Data in Cloud
Authors: Rajani Mrs. K. , Sreeja Y. , Tejaswini T. , Manasa B.
Published: August 2022

Abstract: Outsourcing data to a third-party administrative control, as is done in cloud computing, gives rise to security concerns. The data compromise may occur due to attacks by other users and nodes within the cloud. Therefore, high security measures are required to protect data within the cloud. However, the employed security strategy must also take into account the optimization of the data retrieval time. In this paper, we propose Division and Replication of Data in the Cloud for Optimal Performance and Security (DROPS) that collectively approaches the security and performance issues. In the DROPS methodology, we divide a file into fragments, and replicate the fragmented data over the cloud nodes. Each of the nodes stores only a single fragment of a particular data file that ensures that even in case of a successful attack, no meaningful information is revealed to the attacker.
A Distributed Intrusion Detection System for AODV Network
Authors: Jaiswal Ms. Rashmi , Amarji Ms. Chandramala
Published: August 2022

Abstract: The Ad hoc On-Demand Distance Vector (AODV) routing protocol, designed for mobile ad hoc networks, offers quick adaptation to dynamic link conditions, low processing and memory overhead, and low network utilization. However, without keeping in mind the security issues in the protocol design, AODV is vulnerable to various kinds of attacks. This thesis analyzes some of the vulnerabilities, specifically discussing attacks against AODV that manipulate the routing messages. We propose a solution based on specification-based intrusion detection to detect attacks on AODV. Briefly, our approach involves the use of finite state machines for specifying correct AODV routing behavior and distributed network monitors for detecting run-time violation of the specifications. In addition, one additional field in the protocol message is proposed to enable the monitoring. We illustrate that our algorithm, which employs a tree data structure, can effectively detect most of the serious attacks in real time and with minimum overhead. Routing attacks will have distressing effects over the network and bequest a significant challenge once planning strong security mechanisms for vehicular communication. In this paper, we examine the effect and malicious activities of a number of the foremost common attacks and also mention some security schemes against some major attacks in VANET. The attacker's aim is only to modify the actual route or provides the false data about the route to the sender and also some attackers are only flooding unwanted packets to consume resources in available network. Various routing approaches are also mentioned in the paper because the routing of data is very important to deliver the traffic information to leading vehicles. It's advised that a number of the ways that to approach this made field of analysis issues in VANET might be to fastidiously design new secure routing protocols in which attacks are often rendered meaningless and because of the inherent constraints found in the network, there's a desire for light-weight and sturdy security mechanisms.
Study on the Light Weight Geopolymer Concrete Made of Recycled Aggregates from Lightweight Blocks
Authors: Mathi1 A. Mathu , Lavanya G.
Published: August 2022

Abstract: This study studied the properties of lightweight geopolymer concrete that contained recycled lightweight block aggregate. The recovered blocks are classified as coarse aggregates after being crushed.To reduce greenhouse gas emissions, geopolymers have the potential to be used to create new, environmentally beneficial materials. A new class of building materials called geopolymer concrete (GPC) has a replacement for regular Portland cement concrete (OPCC) and are capable of revolution in the construction sector. The impact of On the strength characteristics, alkaline activators have been investigated. Used fly ash was obtained for this study from a nearby thermal power plant. Samples were produced from low-calcium fly ash through activation with a combination of sodium silicate solution and sodium hydroxide. Fly ash was added to the concrete with a ratio of 0.5. Using a mix proportion and 5,10,15 Molar of sodium hydroxide solution, geopolymer specimens were cast. The samples underwent compression testing. test with ambient temperatures for curing. From the analysis ofLiterature suggests that the combination of the aforementioned ingredients is healing. FromAccording to a review of the literature, the amalgamation of the aforementioned elementshas a favorable effect on the strength properties of geopolymer concrete. Since fly ash is viewed as a waste product, geopolymer concrete made from low-calcium fly ash costs less than Portland cement concrete as a result. Lowcalcium fly ash-based geopolymer concrete has good compressive strength, very little drying shrinkage and minimum creep, great resistance to sulphate attack, and superior acid resistance.
A Comparative Analysis of Biophilic Approach in Building Design
Authors: Neha Ar. K. , Pragadeeswari Ar. R. , Saranya Ar. K. , Yogapriya Dr. G. , Anju Ar. S.
Published: August 2022

Abstract: Today's growing modern cities become a cause for a greater number of environmental issues like global warming, earthquake, urban heat effects, and pollution, which ends in environmental degradation. People are spending a large part of their life in a confined environment, henceforth we need to consider their perspective in those spaces and bring sustainable ideas in it. As a designer and architect, we play a major role in implementing the nature-based approaches like biophilic design in our projects to create awareness among people about sustainable built forms. This becomes a connecting component between humans and nature on an infrastructure level and becomes more effective physically and mentally for the human life to live in. This study reviews the various outcomes in different climatic zones, its advantages and its well-being in environmental behavior. This ideology would work efficiently and adaptable to its surrounding environment and helps solve environmental issues in today’s world
An Essay on Quantum Processors
Authors: Pranav K. V. R .
Published: August 2022

Abstract: Fundamentally we need a processor to carryout computations and intelligent jobs. A CPU in a computer based on Intel technology has been common. As is time getting advanced researchers continued working on large problems for solutions with in minimum time. They expect quantum computers could give good answer in minimum time. This article tried to understand the quantum processors.
A Survey on Real Time Sign Language Detector using ML
Authors: Gattani Parag , Laddha Shreya , Srivastava Sakshi , BM Vikranth
Published: August 2022

Abstract: With the rapid growth in the field of object detection, developing a sign language detector as it is the main instrument of correspondence for physically challenged individuals has invoked the need for such a system. Communication via gestures is a shelter for the genuinely provoked individuals to communicate their contemplations and feelings. With the assistance of computer vision and neural organizations, we can recognize the signs and show the respective text as the output. This paper is a survey based on a broad collection of research papers on the related domain to propose an efficient and accurate model with the core functioning of a better response time and real-time detection using various machine-learning algorithms.
Singer Identification by Vocal Parts Detection and Singer Classification Using LSTM Neural Networks
Authors: Rao K. Rajashekhar , Sharvani K. , Vaishnawi Ch. Shri , Marina Margaret
Published: August 2022

Abstract: Identification of singers is considered an important research area in audio signal processing. It has acquired the scientist’s intrigues in two primary branches,1) recognizing vocal parts of polyphonic music, and 2) Classifying Singer. Here, we plan to handle the two issues, simultaneously. Techniques like GMM, SVM, and HMM have previously been utilized in classifying singers. In this work, we proposed a system for singer identification using Deep Learning and Feed Forward Neural Networks, which to the best of our knowledge have not been used for this purpose before. Preprocessing involves examining large sets of audio features to extract the most efficient set for the recognition stage. Our work is divided into several stages. To begin with, the vocal parts of all music files are identified utilizing an LSTM network which can perform well for the time series information, for example, audio signals. Then, at that point, an MLP network is integrated and contrasted with an SVM classifier in order to classify the gender of the singers. At last, one more LSTM network is involved to recognize every singer ID, and contrasted with MLP network in a similar task. In each step, various classifiers are analyzed and the outcomes are looked at, which affirm the effectiveness of our technique contrasted with the best in class.
Construcción de la interculturalidad crítica en una cooperativa artesanal de mujeres rarámuri y mestizas
Authors: Ruiz Salazar Grissel Alejandra , Martínez Corona Guadalupe Beatriz , Zapata Martelo Emma , Pérez Hernández Luz María , Arras Vota Ana María de Guadalupe , Garza Bueno Laura Elena
Published: August 2022

Por la existencia de la colonialidad histórica en las relaciones interétnicas entre población mestiza (dominante) y población rarámuri (subalternizada), en Chihuahua, México, interesó conocer una experiencia organizativa desde la intercultural crítica (opuesta al simple reconocimiento de la presencia multicultural), en una cooperativa artesanal integrada por 21 mujeres de las culturas rarámuri y mestiza-occidental, en la ciudad de Chihuahua. El objetivo fue identificar la práctica de elementos de la interculturalidad crítica o de expresiones de la colonialidad en las relaciones sociales de sus integrantes. Se empleó un enfoque cualitativo de investigación con el uso de la observación y aplicación de entrevistas en profundidad. Se identificaron componentes de la práctica de la interculturalidad crítica en las relaciones, interétnicas, intragenéricas y laborales en procesos organizativos de la cooperativa, como: intercambio de saberes, toma de decisiones horizontales, reconocimiento mutuo, fortalecimiento de capacidades. También, presencia de elementos colonizadores asociados a mecanismos de mercado de productos artesanales y normatividades ajenas a la cultura rarámuri. El potencial democratizador de la práctica de la interculturalidad crítica se visibilizó en la sororidad e intercambio de elementos culturales, que no atentan la preservación de las identidades étnico culturales de las participantes.
The Effects of Platelet-Rich Plasma in Conjunction with Rehabilitation for Lower Extremity Musculoskeletal Pathologies
Authors: Masaracchio Michael , Kirker Kaitlin
Published: August 2022

Background: Platelet-rich plasma (PRP) has been considered for its role in facilitating the body’s own healing processes, with the potential to complement rehabilitation in the management of lower extremitymusculoskeletal pathologies.Methods: Eligible studies were randomized clinical trials and quasi-experimental trials with completed data analysis; published in English; recruited participants aged >18 years; had at least two groups, with one intervention group receiving PRP injection alone or PRP injection and rehabilitation, and the comparison group receiving either rehabilitation alone or a control group receiving saline and rehabilitation; included at least one outcome measure of pain, disability, quality of life, or return to play. An electronic search was conducted using PubMed, Embase, Cochrane, Pedro, and clinicaltrials.gov. Methodological quality was assessed using the Cochrane Collaboration Risk of Bias (RoB) tool. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to assess the quality of evidence. Meta-analyses were conducted across outcomes in each pathology when possible.Results: Twenty-one studies assessed Achilles rupture, Achilles tendinopathy, lateral ankle sprain, high ankle sprain, hamstring injury, knee osteoarthritis, acute muscle injury, patellar tendinopathy, and plantar fasciitis, with an average RoB score of 9.9 out of 12. Meta-analyses for Achilles rupture (n = 270) revealed a nonsignificant effect on disability in the short and long term (high level of evidence) when comparing PRP, immobilization, and exercise/physical therapy to placebo, immobilization, and exercise/physical therapy. Meta-analyses for Achilles tendinopathy revealed a nonsignificant effect on pain (n = 64) in the short term, and disability in the short (n = 138) as well as long term (n = 192) (very low to low level of evidence) when comparing PRP and exercise to placebo and exercise.Conclusions: While individual studies demonstrated significant findings across outcomes, the non-significant pooled results and inability to perform further meta-analyses made it difficult to provide definitive recommendations for the addition of PRP to exercise for lower extremity musculoskeletal pathologies. Future studies should standardized PRP exercise rehabilitation protocols with better dosage parameters, consider larger sample sizes, and have short and long term follow-up periods consistent with the Cochrane Collaboration.
Evaluating the Accuracy of Computed Tomography of the Kidneys, Ureters, and Bladder Interpretation by Urology Trainees for Suspected Acute Nephrolithiasis
Authors: Daggamseh1 Abdallah M.K. , Robinson Richard , Dukic Ivo
Published: August 2022

Aim: This study aims to evaluate the interpretation accuracy of urology trainees in reporting computed tomography of the kidneys, ureters, and bladder (CT-KUB) compared with the formal radiology reports in patients with suspected acute nephrolithiasis.

Methods: A sample of 12 consecutive CT-KUB scans for suspected acute nephrolithiasis was prospectively compiled and displayed using a software PACS viewer. 11 urology trainees, with an average of 24 months of urology specialist training, interpreted each scan. A total of 132 urology trainees’ reports were compared to the formal radiology reports for agreement in detecting key findings (presence or absence of stone disease), signs of urinary tract obstruction, clinically significant findings, and clinically non-significant findings.

Results: There was a high level of agreement between urology trainees and radiologists for detecting key findings (98.4%) and clinically significant abnormalities (72.7%). There was less agreement in detecting all signs of urinary tract obstruction (56.2%) and non-clinically significant findings (36.8%).

Conclusion: This study shows that urology trainees can accurately report CT KUB studies for key findings and clinically significant abnormalities. This may improve ongoing acute management and early patient discharge. However, their findings should be verified against formal radiological reports.
Is Group and Saving Before the Modern Bipolar Transurethral Resection of the Prostate Still Necessary?
Authors: Kretzmer Leo , Damola Adebiyi , Libotte Chloe , Ehsanullah Syed Ali , Jones Adam , Apakama Ike
Published: August 2022

Introduction: Group and save (G&S) sampling is commonplace for patients undergoing transurethral resection of the prostate (TURP) due to the historically high risk of bleeding. However, modern adjustments to the procedure, including the advent of bipolar TURP in saline, have significantly reduced this risk. This study assessed whether routinely performing G&Ss before the modern TURP is still appropriate.

Materials and Methods: This study was a retrospective review of all patients who underwent a TURP from January 2009 until December 2019 in one centre. A total of 687 patients were identified during this period. In addition, data was collected on G&S samples, blood products, and postoperative complications such as clot retention or if patients required a blood transfusion.

Results: All patients had G&S samples taken before their operation. Only six (0.87%) patients required a blood transfusion. Half were transfused intra-operatively and half post-operatively. Remarkably, none of the transfused patients were below the National Institute for Health and Care Excellence (NICE) threshold to transfuse of <70g/L(8). Six patients were also noted to develop clot retention following the catheter removal.

Discussion and Conclusion: This study has determined that patients undergoing a TURP rarely require blood transfusions. We propose that the practice of routinely taking G&S samples before this procedure should be reviewed. This would give a financial benefit and relieve patients of the unnecessary test. We would recommend thorough optimisation of patients before surgery, including review of anticoagulation and correction of any preoperative anaemia.
KOMUNIKASI ANTARPRIBADI GURU TERHADAP SISWA BERKEBUTUHAN KHUSUS DALAM MEMBENTUK KEPERCAYAAN DIRI SISWA DI SEKOLAH LUAR BIASA NEGERI (SLBN) DESA SANSARINO KABUPATEN TOJO UNA-UNA
Authors: Ningsih Fitriani Puspa , Mohamad Nur Santi M.
Published: August 2022

State Extraordinary School (SLBN) Sansarino Village, Tojo Una-Una Regencyis a Special School which is devoted to children with special needs to develop knowledge and ways to socialize with others so that they can better understand self-confident. Students with special needs are also students who need special attention because they need guidance and education in living their lives. The need for inclusion, the need for control and the need for affection shown by the teacher to students greatly helps the teacher's teaching and learning process. Interpersonal communication at the SLBN of Sansarino Village, verbally and non-verbally, was carried out well and the teachers also made efforts to increase self-confidence in Children with Special Needs. Such as efforts to present a comfortable and fun teaching and learning process for students, provide motivation to students, increase the competitive spirit among students, not discriminate against weak children, provide training to students to increase self-confidence. Students are able to control their behavior well in daily life, can adapt and interact, have a sense of mutual concern, a sense of social solidarity, tolerance for each other so that there is no sense of being left out. Because they have a sense of mutual need, kinship and respect for one another.
RESPON MASYARAKAT TERHADAP PROGRAM VAKSINASI COVID-19 DI KABUPATEN POSO PROVINSI SULAWESI TENGAH
Authors: Aepu Sitti Hajar N. , Bakari Yulianti , Claudia Jeane
Published: August 2022

This study discusses vaccination, where the government's efforts to protect the health of its citizens from the Covid-19 virus are carried out simultaneously in Indonesia. This study aims to describe and analyze the extent of public knowledge and experience of the Covid-19 vaccination program and the response shown by the community to accept or reject the vaccination. Qualitative research method with the stages of observation and in-depth interviews as well as conducting a literature review related to the research focus. The rhesults showed that the knowledge and experience of the people of Moengko Baru Village about vaccination was still lacking and varied, where more information was obtained from social media, mass media so that they believed in hoax news circulating and would indirectly affect the response to behavior, attitudes and actions in vaccinating. However, some people already have good knowledge of the vaccination and are willing to be vaccinated for health and for immunity against diseases/viruses. The Government of Poso Regency has carried out a socialization program in the community so that the public better understands the importance of vaccination in the formation of herd immunity or group immunity.
TOXIC PARENTS PADA PODCAST
Authors: Berliana Sandra , Sumardjijati  , Claretta Dyva , Arviani Heidy
Published: August 2022

The term toxic parents is being discussed lately because many Indonesian parents are learning to be better mothers and fathers by avoiding their parent’s mistakes. Toxic parents are parents who have negative parenting patterns that are consistently and dominant in their children's lives, including abuse, violence, and humiliation that can cause trauma, mental damage, and harm the child in the long term. Considering that many young people feel related to the issue of toxic parents, the podcast Curhat Babu tries to raise this issue. This study aims to find out how early adults accept toxic parents on the episode of Curhat Babu podcast “Bisakah Kita Mengubah Orang Tua Kita?”. This study uses descriptive qualitative method. Data collection techniques used are in-depth interviews and documentation. This study uses a reception analysis of Stuart Hall's Encoding-Decoding model which divides the audience's meaning into three positions: dominant-hegemonic, negotiated, and opposition. The results showed that the reception of the informants varied, but tended to be in a dominant position, where the audience accepted the dominant meaning in the podcast as whole which states that children cannot demand to change parents so the control is on themselves to break the toxic parent’s chain. Life experience, knowledge, and religion factors influence the various meanings and receptions of the informants.
GAYA KOMUNIKASI PIMPINAN DALAM MEMOTIVASI SEMANGAT BEKERJA DI SUB BAGIAN KOMUNIKASI PIMPINAN PEMKAB TEGAL
Authors: Imanidar Oka
Published: August 2022

Communication has a very important role to support all activities, especially within the organization. When there is no communication between leaders and employees or vice versa, it will hinder the process of performance of organizational goals. The leader's communication style must also be in accordance with the situation and conditions of the organization he leads. Because it can affect the performance and productivity of its employees. The purpose of this study was to describe the communication style of the leadership of the Tegal Regency Leadership Communications Sub Division in motivating the work spirit of the employees. This study uses descriptive qualitative research with data collection techniques by observation, interviews and documentation. There are 6 informants selected by the researcher. Results Based on research on leadership communication style in motivation to work in the Tegal Regency Leadership Communications Sub-Section, it can be concluded that the leadership in the Leadership Communications Sub-Section uses communication. In motivation, the leader provides instructions, instructions, information and explanations to employees. However, it is not uncommon for leaders here to use horizontal communication, namely exchanging messages or ideas with each member in the organization. This is in an open attitude that is owned by the leadership. Leadership communication style Sub Division of Leadership Communications uses two communication styles, namely The Equalitarian Style and The Relinguishing Style. In the motivation to work employees, the leadership of the Sub-Division of Leadership Communications uses two-way communication. This is very effective in influencing employees to work hard. Because two-way communication is very important used by leaders to create good and effective communication.