bluuebunny/crossref_metadata_2025 huggingface dataset:
Projetos de desenvolvimento para a Amazônia e a expansão da dendeicultura
Authors: De Sousa Claudiane de Fátima Melo
Published: January 2020

No ano de 2004, o governo brasileiro lançou o Programa Nacional de Produção e Uso de Biodiesel (PNPB), um programa orientado para a diversificação da matriz energética brasileira. Como parte desse programa, em 2010 foi lançado o Programa de Produção Sustentável de Óleo de Palma no Brasil. Este programa teve forte impacto na Amazônia brasileira, pois a principal diretriz incluía a expansão da dendeicultura por meio de incentivos fiscais, linhas de créditos para a agricultura familiar e para as empresas produtoras e beneficiadoras de dendê. Os dois programas tinham como objetivo o desenvolvimento sustentável no meio rural, a geração de renda e a inclusão social. Com promessas de melhoria de vida e de renda, agricultores familiares foram incentivados a plantar dendê e muitas famílias fizeram contratos de compra e venda com grandes empresas do ramo. Este trabalho é um recorte de duas pesquisas que foram realizadas nos anos de 2013-2014; 2015-2019 o primeiro para minha dissertação de mestrado e o segundo para minha tese de doutorado. O recorte que aqui apresento chama atenção para os discursos que estão por trás do referido programa, discutindo à qual perspectiva de desenvolvimento este se alinha e ainda problematizar o imaginário sobre a Amazônia que em geral compõe parte do desenho de políticas de desenvolvimento que, via de regra, não tem levado a realidade socioeconômica da região em consideração. Por fim, contraponho as promessas do programa aos resultados obtidos e concluo que esse foi mais um programa de desenvolvimento que não logrou a inclusão social e econômica do homem e da mulher da região amazônica.Palavras-chave: Dendeicultura. Biopalma. Biodiesel. Agricultura familiar. Desenvolvimento.
Some problems of formation of the tourism industry at the Kazakh sectors of the Silk Routes
Authors: Kulgildinova T. A. , Zhubanova M. H. , Aytbaeva G. D. , Tusupbekova G. M. , Abdikerimova G.
Published: January 2020

The aim of this study is to review some problems of formation of the tourism industry at the Kazakh sectors of the Silk Routes. The study conducted a literature review method. The conclusion has appeared that among the most promising projects of the XXI century the international program for the revival of the Silk Road on the right holds a special place in its historical and universal scale. Mausoleum of Khoja Ahmed Yasawi, in the city of Turkestan, and Tamgaly petroglyphs (Almaty region) are included in the list of World Cultural Heritage by UNESCO. This is a clear proof that our ancestors left a rich heritage and recognised worldwide. We have a unique of its kind, the only post-Soviet state program â€˜Cultural Heritageâ€™ in the country. Thanks to her, we have restored dozens of landmarks. Kazakhstan is rich in historical monuments of the country and some objects of archeology are a thousand year old. Not surprisingly, we go to the historians from many countries.

Keywords: Tourism, industry, study, research, formation.
Сerebroprotective effect of some phenolic acids under conditions of experimental brain ischemia
Authors: Voronkov A. V. , Pozdnyakov D. I. , Nigaryan S. A.
Published: January 2020

The aim of the study was to evaluate the cerebroprotective effect of some phenolic acids under the conditions of experimental cerebral ischemia in rats.

Materials and methods. The experiment was conducted on male Wistar rats weighing 220–240 g. Focal cerebral ischemia was modeled by irreversible right-sided thermocoagulation of the middle cerebral artery under chloral hydrate anesthesia (350 mg/kg, intraperitoneally). The experimental compounds (4-hydroxy-3.5-di-tert-butyl cinnamic acid, caffeic acid and gallic acid 100 mg/kg each compound) and a reference drug (Mexicor – 100 mg/kg) were administered intragastrically next day after the surgery and then for three daysrunning. The effect of the test-compounds on the cognitive functions of the rats was evaluated by CRPA and TEA tests. The influence of the compounds on the changes in the concentration of lactate, pyruvate, homocysteine, as well as the degree of cerebral edema formation and necrosis of the brain tissue, were studied.

Results. In the study, it has been established that against the background of the focal cerebral ischemia, the administration of caffeic, 4-hydroxy-3,5-di-tert-butylcinnamic and gallic acid, contributed to the preservation of a memorable trace in rats, as well as a decrease in lactate concentration (by 40.37% (p<0.05), 151.26% (p<0.05), 48.02% (p<0.05)) and pyruvate (by 96.6,% (p<0.05), 38, 78% (p<0.05), 33.3% (p<0.05)), homocysteine (by 59.6% (p<0.05), 102.18% (p<0.05), 28.8% (p<0.05)), аnecrosis zone (by 122.79% (p<0.05), 165.11% (p<0.05), 12.38% (p<0,05)) and cerebral edema (by 10.47% (p<0.05), 11.08% (p<0.05), 9.92% (p<0.05)) relative to the NC group of rats.

Conclusion. The obtained data indicate the possibility of further detailed investigation of the cerebroprotective effect of 4-hydroxy-3,5-di-tert-butylcinnamic, caffeic and gallic acids.
Dynamics of the acute viral hepatitises morbidity and range of medicinal preparations for treatment in hospital environment in the Volgograd region (the Russian Federation), 2016–2018.
Authors: Ganicheva L. M. , Ioannidi E. A. , Panfilova O. A. , Tyurenkov I. N. , Knyazeva Yu. S. , Kaisheva N. Sh.
Published: January 2020

The aim of the study was to investigate the prevalence of acute viral hepatitises A, B and C in the Volgograd region; the range and identification of the most frequently prescribed pharmacological groups to be used in hospital environment; and analyzing the price dynamics of medicines. These factors will make it possible to assess the state of the medicine provision for the patients with this disease in hospital environment. 

Materials and methods. In the study, the following methods have been used: comparison, a method of grouping indicators and a structurallogical method. The materials were the hepatological department patients’ treatment sheets (Volgograd Regional Clinical Infectious Diseases Hospital N1).

Results. Acute hepatitis A is the most common (46.9%), acute hepatitis B occupies the second position (27.4%), and acute hepatitis C – the third one (25.7%), where in 46.2%, 23.5% and 14.7%, respectively, are accounted for by icteric viral hepatitis. Hepatoprotectors, symptomatic medications and rehydration and detoxification medicinal preparations are prescribed for all forms and degrees of the disease severity.

Conclusion. The study has revealed a decreased morbidity of acute viral hepatitises A, B and an increased morbidity of acute viral hepatitis C in the Volgograd region. Among all the types of hepatitises, the prevailing one is the icteric form of moderate severity. The range of medicinal preparations prescribed for the treatment of acute viral hepatitises has been studied. Most often, doctors prescribe hepatoprotectors, rehydration and detoxification medicinal preparations. The study of price dynamics, showed a predominant increase in hepatoprotectors and a decrease in medicines for rehydration and detoxification. The results obtained indicate a tendency towards the improvement of drug provision in the Volgograd Region, for the patients with acute viral hepatitises. Besides, the results of the study give an opportunity to consider the ways of its further optimization.
Kınık (İzmir) İlçesi Kavun Ekiliş Alanlarında Aulacophora foveicollis (Lucas) (Coleoptera: Chrysomelidae)’in Bulaşma Oranı ve Populasyon Değişimi Üzerinde Araştırmalar
Authors: ELTEZ Sumru , ELTEZ Raşit Zeki , EREN Erkan , ÇETİN Mehmet , KARSAVURAN Yusuf
Published: January 2020

Amaç:İzmir
İli Kınık İlçesinde kavun tarlalarında Aulacophora
foveicollis’in bulaşma oranı ve populasyon değişiminin saptanması

Materyal ve Metot: Çalışmanın ana
materyali İzmir İli Kınık İlçesinde yetiştirilen Cucumis melo L. (Cucurbitaceae) (kavun) ve Aulacophora foveicollis’in tüm biyolojik dönemlerine ait bireyleri
oluşturmuştur. Bulaşma
oranı çalışmaları 2017 ve 2018 yıllarında Sucahlı mahallesinde 6, Yayakent mahallesinde 4 ve Poyracık mahallesinde
5 adet seçilen tarlalarda fide, çiçeklenme, meyve tutumu ve hasat dönemlerinde
50’şer bitkide yapılmıştır. Populasyon değişimi ile ilgili sayımlar Sucahlı ve
Poyracık’da seçilen 4’er tarlada haftalık sayımlarla 25’şer bitkide
gerçekleştirilmiştir.

Bulgular: Aulacophora foveicollis’in Kınık İlçesinde
bulaşma oranı %100 olarak belirlenmiştir. Populasyon değişimi fidelerin dikimi
ile Mayıs ayından itibaren artmış, Temmuz ayı ortalarından itibaren azalmaya
başladığı, hasat döneminde bir miktar daha arttığı Eylül ayında hasat
bitiminden itibaren hızla düştüğü gözlemlenmiştir. Sıcaklık arttıkça genel
olarak poulasyonun da arttığı belirlenmiştir.

Sonuç: Bu çalışma ile A. foveicollis’in
bölgede bulaşık olduğu, fide dikimini takiben hasat sonuna kadar kavun
tarlalarında zarar yaptığı belirlenmiştir. Zararlı bu nedenle Nisan ayından
Eylül ayı sonuna kadar kavun tarlalarında bulunabilmektedir. Çalışmadan elde
edilen sonuçlar kavun üreticilerinin, A.
foveicollis’in hangi aylarda fazla olduğunu görmelerini ve zararlı ile
mücadele konusunda daha uygun zamanlarda hareket etmelerine olanak
sağlayacaktır.
Study of the content of the main macronutrients in gluten-free crops and products of their processing
Authors: Urubkov S. A. , Khovanskaya S. S. , Smirnov S. O.
Published: January 2020

The aim of this study was to obtain data on the quantitative ratio of the main nutrients in amaranth grain, as well as products of its processing (blasted grain and flour Krupchatki) in comparison with the more common in Russia gluten-free grain products, such as buckwheat and rice flour, corn and buckwheat. The review of Russian and foreign articles showed quite wide ranges of the content of the main nutrients in amaranth grain. As a result of the study, data on the content of the main macronutrients, i.e. protein, fat, digestible and non-digestible carbohydrates and ash content were obtained. The obtained data showed that the protein content in amaranth grain exceeds the content of this nutrient in buckwheat, as well as rice and corn flour. The total content of lipids in the exploded amaranth grain was 6.41% for dry matter, and surpassed the rest of the studied products in this indicator. The analysis showed a relatively high content of carbohydrates in all the studied products. The amaranth grain carbohydrates are made up 63,25% dry solids, which is lower than in other samples, where the values of this indicator ranged from 65,6 to 80.3% solids, the amount of indigestible carbohydrates in the grain amaranth is almost 2 times higher than this value in other samples. The results obtained in this study can be used in studies of gluten-free crops and products of their processing in the development of specialized gluten-free grain mixtures using amaranth for children's nutrition.
Improving the production technology of bakery products obtained using ingredients of plant origin
Authors: Naumenko N. V. , Potoroko I. Yu. , Kalinina I. V. , Malinin A. V. , Tsaturov A. V.
Published: January 2020

The article considers the possibility of using whole-grain flour from germinated wheat grain as a raw material component containing easily digestible sugars, essential amino acids, vitamins and minerals. For the intensification of the germination process, the treatment of wheat at the acoustic source of elastic oscillations is used at a frequency of (22 ± 1.65) kHz and power of 340 W and an exposure time of 5 minutes. The obtained whole-ground flour from germinated wheat grain has a weighted average particle size of flour 177 ± 25 microns. This flour was used in the production of model bread samples by partial replacement of high-grade flour in the amount of 10–50%. Based on the determination of technological parameters, it was found that the use of whole-grain flour from germinated wheat grain increases the sugar-forming and gas-forming ability of the flour mixture, intensifies the fermentation process. It has little effect on the quantity and quality of gluten. The optimal value of the drop number was found for the first-grade baking wheat flour and whole-grain flour from germinated wheat in a ratio of 80:20, respectively. This ratio was also defined as the best organoleptic evaluation of laboratory test baking bread samples. The model sample had an attractive appearance, a convex brown, uniform porosity, non-sticky, elastic crumb, pronounced taste and aroma. The authors note that the improvement of the production technology of bakery products obtained using whole-grain flour from germinated wheat grain is possible by choosing the optimal dosage of introducing this type of raw material and monitoring the technological parameters of the process.
Chocolate muffins with improved quality
Authors: Plotnikova I. V. , Magomedov G. O. , Shevyakova T. A. , Gubkovskaya V. V. , Plotnikov V. E.
Published: January 2020

Nowadays the production of competitive flour and chocolate confectionery products of improved quality and low cost is an important area. An alternative substitute for cocoa powder - cocoa shell powder - is promising in this regard. It can preserve the color, taste and aroma of the finished product. The objects of study were natural cocoa products obtained by cocoa beans processing - this is cocoa powder and heat-treated powder from cocoa shells. By the chemical composition the enrichment used contains a significant amount of valuable physiological effects of food substances. Compared with cocoa powder, it contains more fiber, cellulose, dietary fiber, minerals and vitamins, its energy value is 3 times lower. The introduction of cocoa shell powder into the muffins recipe intensifies the foaming process of the whipped recipe mixture, and the duration of its whipping is reduced. A rational dosage of cocoa shell powder was determined as 3.5% (by weight of the dough). According to organoleptic characteristics, samples of muffins with cocoa shell powder were not inferior to samples with cocoa powder, while their color, appearance, taste and aroma were improved. Chocolate muffins had a delicate, elastic crumb with uniform thin-walled porosity, had a smooth surface with slight detonations. The results of calculating the nutritional and energy value of the muffins showed that the "Chocolate Delight" muffins with cocoa shell powder contain more dietary fiber, minerals - K, Mg, P, Ca, vitamins - B3, B9, PP. The daily requirement for these nutrients is more than 20%, therefore the developed product can be attributed to functional products. The energy value of the developed "Chocolate Delight" sample is 34.4 kcal lower than the control.
Research of pigments of blue-green algae spirulina platensis for practical use in confectionery technology
Authors: Kalenik T. K. , Dobrynina E. V. , Ostapenko V. M. , Torii Y. , Hiromi J.
Published: January 2020

The article presents a study of the process of isolation of natural blue pigment – phycocyanin from the biomass of blue-green algae Spirulina platensis by water extraction, followed using its water solution as a natural food colorant in the production of milk chocolate. Recently, modern food enterprises are pursuing their policy towards expanding the range of products, which is closely related to the increasing needs of the population in food of a new kind. One of the solutions to this problem is the use of food additives of both natural and synthetic origin. Among the similar components widespread found dyes synthetic origin, which have high coverage rates and relatively low cost. However, many of the permitted in our country synthetic food dyes are banned in several developed countries as potentially dangerous to health. Synthetic dyes of red, yellow and green color have many natural analogues – carotenoids, lutein, chlorophyll, etc., except for the blue dye, the analogue of which is only anthocyanins, which are unstable depending on the pH conditions. In this article were identified phycobiliproteins and chlorophyll a in a water extract of spirulina. The mass concentration of phycobiliproteins and chlorophyll a was determined by spectrophotometric method before and after the addition of ammonium sulfate. A comparative analysis of the effect of fractionation (salting out) on the degree of purification of the phycocyanin solution. Presented and described the technological scheme of extraction of phycocyanin which allows to use it in food technologies as an extract or a dry powder. Established the concentration of phycocyanin extract from blue-green algae spirulina to produce milk blue chocolate. Determined organoleptic and hygienic characteristics of the finished product
Dry functional blend with fruit-berry powders for yeast dough
Authors: Moshkin A. V. , Vasyukova A. T. , Alexeyev A. E.
Published: January 2020

The basic information about functional mixtures is outlined, options for compositions and recommendations for use in baking in mass production are proposed. The characteristic of microbiological, physical and chemical indicators is given, and the results of toxicological studies of dry functional mixtures with fruit and berry powders are given. High-calorie, medium-calorie, and low-calorie composite mixtures have been developed for the centralized production of yeast dough. Dry functional mixtures can be produced according to regulatory documents: TU 9161-004-51926638-11 and TI to TU 9161-004-51926638-11. A patent of the Russian Federation No. 2602629 was obtained for dry functional mixtures with fruit and berry powders. The technological scheme for obtaining a dry functional mixture consists of the following operations: sifting, dosing of prescription components in predetermined proportions: dry egg-milk mixture in the amount of 56.2-61.6% sugar – 20.0-24.3% and salt – 14.1-17.2%. Xanthan (1.06-2.43%) or guar (4.25-5.30%) and fruit and berry powders (1.0-1.5%) are introduced as additional raw materials. Then mixing is carried out, preparation for implementation. The resulting mixture is portioned and packaged in paper bags. Fruit and berry powders were prepared from rose hips, aronia, nettle, bananas, apples and carrots. According to microbiological studies, the degree of contamination during storage during the year corresponds to SanPiN 2.3.2.1078-01, which makes it possible to produce dry functional mixtures with fruit and berry powders for long-term storage. They can be stored in a dry, well-ventilated room in compliance with sanitary rules, with a relative humidity of 65-70% and a temperature of 18-20 °C from 0 to 12 months. It was found that during storage for 12 months. in hermetically sealed paper bags, no powder quality changes were observed. Bakery products made using these mixtures can be recommended for medical, preventive and gerontological nutrition.
New production technology briquetted feed additive
Authors: Lytkina L. I. , Shentsova E. S. , Pereverzeva S. A. , Mikhaylov A. G.
Published: January 2020

Currently, the domestic market of animal feed products represented a wide variety of feed for cattle. However, even the most modern feed are not able to fully compensate for the lack of varietymicro- and macronutrients, vitamins and many other nutrientsThat the animals do not get enough in the process of feeding in a farm pasture and hunting grounds. In this connection, the establishment of a functional product, combining the complex substances needed in the feeding of animals and development of energy-efficient method of its production is important. The proposed technology allows to obtain an energy efficient fodder briquettes with high uniformity and specify the content of bioactive substances necessary for the animal organism growth and development, to provide longer retention products. Аn energy-efficient method for the production of a briquetted feed additive based on grain molasses has been developed, as a result of it the Increase ecological safety of the production line of fodder briquettes is increased, emissions of spent coolants into the environment are reduced, by 10–15% the specific energy costs are reduced through the use of a high-temperature steam compression heal pump.
Researching of features byosinthesis beta-glucans in the micelial mass Aspergillus niger and in non-conditional cereal grains
Authors: Manzhieva B. S. , Sharova N. Y.
Published: January 2020

At the moment, it seems relevant to process mycelial mass as a waste product of citric acid and substandard grain, since there is a problem of recycling production waste. In turn, waste processing makes it possible to isolate a number of unique compounds, such as glucan and chitin. Of interest is the cell wall of micromycetes. Its main structural polysaccharides (chitin and glucan) form a complex called the chitin-glucan complex. Moreover, the content of chitin in micromycetes is higher than in traditional raw materials - shells of marine crustaceans. The mycelial mass of Aspergillus niger micromycete is a promising source of glucan and chitin. Aspergillus niger biomass and substandard cereal grains contain soluble dietary fiber-beta-glucans. They help reduce the risk of cardiovascular disease by lowering cholesterol, control blood glucose, which is very important for patients with diabetes. In addition, because of the ability of beta-glucans to form viscous gels, these chemicals slow down the absorption of sugars. Due to this, there is a decrease in the glycemic index of products. Of greatest interest are glucans of microbial origin. In addition to structural features (more functionally active ?-1,3 / 1,6-bonds), the advantage of beta-glucans derived from biomass is a higher quantitative yield of soluble forms, which are interesting not only in the food industry, but also in medicine . The aim of this work is to study the effect of various carbon sources (raw materials) on the biosynthesis of glucan-containing compounds and their derivatives Aspergillus niger micromycetes. As a result of studies, it was found that the biomass on the corn starch hydrolyzate is the most effective, it contains a high content of beta-glucans.
Methods for obtaining grain bases for food
Authors: Shaimerdenova D. A. , Chakanova J. M. , Mahambetova A. A. , Iskakova D. M. , Yesmambetov A. A.
Published: January 2020

The use of the full potential of grain and leguminous crops laid down in them by nature is an important task in addressing the issues of balanced nutrition of the population, because food products based on these crops satisfy up to 70% of the daily human need for proteins, fats and carbohydrates, micro and macro elements, biologically active substances and remain the most affordable for all categories of consumers. Moreover, the preservation of all macro-, micronutrients, biologically active substances of the source grain remains a serious problem, because in the traditional approach to grain processing, the content of these components inevitably decreases. In the future, this process continues under the influence of technological parameters at all stages of production and storage of products. An analysis of the production technology of grain foundations showed a number of stages specific to each type of production. At the same time, micronization, extrusion and germination are recognized as the most productive. In preliminary studies, 4 types of grain and leguminous crops were identified as the most promising for the production of grain bases, which were subjected to micronization and extrusion according to the optimal conditions established by water absorption capacity and thermodynamic characteristics. Used the device DSC. Samples of selected cultures were germinated. In micronized, extruded and germinated grain bases, the chemical and vitamin composition is determined. A comparative characteristic revealed a promising method for the production of grain bases, which will be further used in food.
Establishment of a test culture to study the effects of ionizing radiation on the opportunistic and pathogenic microflora of food
Authors: Semenova Z. A. , Levshenko M. T. , Kolokolova A. Y. , Ilyuhina N. V. , Kurbanova M. N.
Published: January 2020

Due to the special importance of food in the emergence of acute intestinal infectious diseases and bacterial food poisoning, special attention is paid to the microbiological purity monitoring of food raw materials and food products. Ionizing radiation processing of food – is a promising technology for combating both microorganisms causing spoilage and pathogenic and opportunistic microorganisms – pathogens of dangerous diseases. However, work with vegetative forms of these microorganisms to study the effects of ionizing radiation is difficult because of the need to use in experiments only actively growing culture, which is sensitive to various environmental factors. When studying the effect of ionizing radiation on the microflora of food products, this study describes the investigation of the possibility of using as a test-culture the ascospores of the fungus Aspergillus fischeri instead of vegetative forms of pathogenic and opportunistic cultures. Ascospores of the fungus Aspergillus fischeri are used as a test culture in the development of pasteurization regimes of fruit and vegetable products. A. fischeri ascospores have been shown to have higher resistance to ionizing radiation in the range from 1 to 5 kGy at capacity 10 MeV in comparison with Salmonella enterica, Escherichia coli and Listeria monocytogenes cells. Therefore, in the development of ionizing radiation food processing regimes it is recommended to use ascospores of the fungus A. fischeri as a test culture instead of vegetative forms of bacteria.
Development of physicochemical foundations of the technology of extraction of low-ash graphite from high-carbone rocks of the Jiamusi-Hankaiskaya province
Authors: Molchanov V. P. , Medkov M. A.
Published: January 2020

The majority of high technologies which are indicators of the level of development of the industrial production in the advanced countries are inconceivable without graphite use. The bulk of graphite is imported into Russia from abroad. Enormous resources of crystal graphite are concentrated in ore deposits of the Jiamusi-Hankaiskaya province with submeridional strike towards the adjacent territories of the South of the Far East of Russia and the northeast of China. There are features of Dalnerechensk group (with Filinskoye being the largest of them), deposits of of Lesozavodsk group (Tamginskoye, Turgenevskoye) and graphite-ore giant of Liumao Mashan group of the Heilongjian province in the Northern, central and Southern sides of this province respectively. A characteristic feature of the graphite ores of these objects is the abundance of inclusions of quartz, native metals, intermetallic compounds. Using the deposits of the Lesozavodsk group as an example, the possibilities of extracting high-purity graphite from them were investigated. The results of the research of the conditions of the purification of the natural graphite with the usage of the processes of the hydrodifluoride technology are given. The interaction of the major impurity elements of the concentrate with NH4HF2 resulting in the formation of the complex fluorine ammonium salts and simple fluorides is established to occur during processing of the graphite concentrate with ammonium hydrodifluoride. Conducting the fluoridization with usage of 20 percents of surplus of NH4HF2 has been found to allow reaching the complete fluoridization of the impurity components which are present in the graphite. The complex fluorine ammonium salts and the fluorides of alkaline metals have appeared to be removed from fluoridated concentrate by means of the water leaching. As a result of the experiments, the foundations for the introduction of promising industrial hydrofluoride technology for the purification of natural graphite from impurities have been created. The application of the developed basic scheme for the production of high-purity graphite opens up wide prospects for the deep processing of graphite ores in the deposits of Primorye
Assessment of investment attractiveness of Voronezh region
Authors: Galimova I. I. , Pasynkova O. M. , Chaikovskaya L. N.
Published: January 2020

The economic security of a state, its subject, and also a single organization is largely determined on the basis of the assessment of individual components of economic security. They are financial, intellectual and personnel, technical and technological, political and legal, environmental, informational, power components. A special place among the elements of the economic security of the region belongs to the investment factor, the magnitude of which is influenced by many factors from various fields of activity. The level of influence of factors on the investment potential of the Voronezh region is considered in the presented work. The article reflects possible methods for assessing investment attractiveness, among which the rating method and the method for evaluating individual statistical indicators are highlighted. The advantages and disadvantages of each of them are considered. In conducting the study, the authors used the analysis of statistical indicators, which allow assessing both the investment potential of the region and the investment risks that inevitably arise during the implementation of projects. As a result, industrial, labor, consumer, infrastructural, financial, institutional, innovation and resource potential of the Voronezh region, as well as economic, social, criminal and environmental risks were analyzed. For all the studied indicators, growth rates were calculated, indicating an increase or decrease in the investment attractiveness of the region over time. According to the results of the work done, it was noted that, despite the instability in changing some of the factors studied, the Voronezh Region occupies a worthy place in the Central Federal District (CFD) in terms of investment attractiveness and is the leader in terms of financial investments in the economy.
Foreign experience of supporting development of technologies of storage of energy
Authors: Kalimullin L. V. , Levchenko D. K. , Smirnova Y. B. , Tuzikova E. S.
Published: January 2020

The purpose of the research is to analyze the needs for supporting developed systems of energy storage and storage systems. The analysis of the main global global challenges and challenges associated with the prospects for the development of energy storage and storage systems in Russia. Energy storage and storage technologies in the leading countries for the development of this energy industry (European Union countries, USA, China). Recommendations are formulated to ensure the possibility of creating energy storage systems in Russia. Scientific novelty lies in the development of theoretical and methodological provisions of a system for stimulating the development of energy storage and storage technologies, based on experiments with a high level of technological development in the energy sector, capable of setting and achieving strategic technological fronts of state development. Energy industries, including industry development programs and corporate documents of energy companies; in support of projects for the implementation of initiatives for the development and development of energy storage systems; in the process of developing educational programs in the field of energy and cooperation projects.
Energy saving technology of allocation of protein-bearing fractions from oilseeds with use of the paroezhektorny thermal pump
Authors: Shevtsov A. A. , Tertychnaya T. N. , Tkach V. V. , Serdyukova N. A.
Published: January 2020

The production cycle of complex processing of oilseeds with receiving vegetable oil, soluble and insoluble fraction from mix of the crushed pressing with heated water is offered; a squirrel from soluble fraction, the dried-up insoluble fraction. The main basic decision on decrease in energy consumption was the optimum choice of temperature differences in the evaporator and sections of the two-section condenser when receiving drying agents, the cooling air and warm water. The deviation from these values inevitably leads to increase in the consumed energy: fall of temperature of boiling of coolant in the evaporator on 1 °C results in need of increase in a consumption of working steam in the ejector of the paroezhektorny thermal pump, and therefore to an energy overexpenditure for 5–7 %, and temperature increase of condensation on 1° C leads to increase in power consumption by 2.0–2.5 %. The offered technology expands borders of energy efficient interface of objects of various temperature potentials on the basis of utilization and recovery of secondary energy resources. Universal approach in creation of the competitive technology providing heat generation and cold weather for in common proceeding heattechnological processes is fully realized. Ecologically safe conditions in implementation of technology due to use of water as coolant, excepting use toxic, vzryvo – and fire-dangerous working environments and also at the expense of the organization of the closed recirculation schemes for material and power streams with considerable decrease in removal of secondary energy resources from the scheme warm and cold supply are created.
Fast Multiple Projection Image Method for VR and AR Near-eye 3D Display
Authors: Yang Xin , Zhang HongBo , Wang QingHua
Published: January 2020

We propose a computer-generated hologram method for near-eye virtual reality and augmented reality 3D display. A 3D object located near the holographic plane is projected onto a projection plane to obtain a plurality of projected images with different angles. The hologram is calculated by superposition of projected image convolution with a specific PSF through the interference of reference wave with object wave. Holographic 3D display systems with LED as illumination, 4f optical filtering system and lens as eyepiece for near-eye VR display and HOE as combiner for near-eye AR display are designed. The results show that the proposed method is about 38 times faster than the conventional point cloud method. The proposed method is flexible to produce speckle noise free high-quality VR and AR images with efficient focus and defocus capabilities.
Astrocyte Infection during Rabies Encephalitis Depends on the Virus Strain and Infection Route as Demonstrated by Novel Quantitative 3D Analysis of Cell Tropism
Authors: Potratz Madlin , Zaeck Luca , Christen Michael , teKamp Verena , Klein Antonia , Nolden Tobias , Freuling Conrad M. , Müller Thomas , Finke Stefan
Published: January 2020

Although conventional immunohistochemistry for neurotropic Rabies virus (RABV) usually shows a high preference for neurons, non-neuronal cells are also potential target cells and abortive infection of astrocytes is considered a main trigger of innate immunity in the CNS. While in vitro studies indicated differences between field and less virulent lab-adapted RABVs, a systematic and quantitative comparison of astrocyte tropism in vivo is lacking. Here, a recently developed solvent-based tissue clearing technique was used to measure the RABV cell tropism in infected brains. Immunofluorescence analysis of 1 mm-thick tissue slices enabled 3D segmentation and quantification of infection frequencies of astrocytes and neurons. Comparison of highly virulent street virus clones from fox, dog, and raccoon with three lab strains of intermediate and low virulence revealed remarkable differences in the ability to infect astrocytes in vivo. While all viruses and infection routes led to comparable neuron infection frequencies, striking differences were detected for the infection of astrocytes. Consistent and inoculation route-independent astrocyte infection by field viruses, together with route-dependent or undetectable astrocyte infection by lab-adapted or vaccine viruses strongly suggests a model in which the ability to establish productive astrocyte infection in vivo functionally distinguishes field and attenuated lab RABV strains.
Effect of Manure and Urea Fertilization on Yield, Carbon Speciation and Greenhouse Gas Emissions from Vegetable Production Systems of Nigeria and Republic of Benin: A Phytotron Study
Authors: Olaleye Abimfoluwa , Peak Derek , Shorunke Akeem , Dhillon Gurbir , Oyedele Durodoluwa , Adebooye Odunayo , Akponikpe P.B. Irenikatche
Published: January 2020

Fertility management techniques being promoted in sub-Saharan Africa (SSA) seek to grow indigenous vegetables economically and sustainably. This study was conducted in a phytotron chamber and compared yield, soil carbon (C) speciation and greenhouse gas (nitrous oxide (N2O) and carbon dioxide (CO2)) emissions from SSA soils of two ecoregions; the dry savanna (lna, Republic of Benin) and rainforest (Ife, Nigeria) cultivated with local amaranth (Amaranthus cruentus) under manure (5 t/ha) and/or urea (80 kg N/ha) fertilization. Vegetable yield ranged from 1753 kg/ac to 3198kg/ac in the rainforest, RF, soils and 1281 kg/ac to 1951 kg/ac in the dry savanna, DS, soils. Yield in the urea treatment was slightly higher compared to the manure+urea treatment, but the difference was not statistically significant. Cumulative CO2 emissions over 21 days ranged from 497.06 to 579.47 g CO2 in the RF, and 322.96 to 624.97 g CO2 in the DS, while cumulative N2O emissions ranged from 60.53 to 220.86 mg N2O in the RF, and 24.78 to 99.08 mg N2O in the DS. In the RF samples, the combined use of manure and urea reduced CO2 and N2O emissions but led to an increase in the DS samples. ATR-FTIR analysis showed that the combined use of manure and urea increased the rate of microbial degradation in the soils of the DS, but no such effect was observed in soils of the RF. We conclude that combining manure and urea fertilization has different effects on soils of the two ecoregions, and that RF farmers can reduce agricultural emissions without compromising soil productivity and yield potential.
THE TOLERANCE AND YIELD COMPONENTS OF RICE BREEDING LINES SELECTED UNDER LOW AND OPTIMUM NITROGEN CONDITIONS
Authors: Lestari Angelita Puji , Suwarno Suwarno , Trikoesoemaningtyas Trikoesoemaningtyas , Sopandie Didy , Aswidinnoor Hajrial
Published: January 2020

One of the important issues on rice breeding is to develop new rice lines suitable for nitrogen efficiency in the suboptimum environment. The study aimed to evaluate the tolerance and yield components of rice breeding lines selected under low and high nitrogen conditions. The F6 generation from two cross-combinations of Gampai/IR77674 and Progol/Asahan, were evaluated in the dry season of 2014 under N suboptimum and N optimum conditions. A total of 172 lines plus six check varieties derived from the low and high N environment selection were evaluated under low N rate (34.5 kg N ha-1) and high N rate (138 kg N ha-1), arranged in an augmented design. Six check varieties were relocated three times in each block. Plot size was 5.5 m2 and plant spacing 20 cm x 20 cm. Data were collected for grain yield and major yield components. Results showed that the different status of nitrogen fertilizer affected the number of productive fillers, number of filled grains, 100-grain weight, and grain yield. Different cross combinations exhibited different results in the progeny performance. Ten lines have a higher yield also tolerant to low N condition, i.e. B14250F-6-9, B14250F-1-4, B14250F-9-9, B14250F-6-4, B14250F-5-2, B14262F-15-6, B14250F-2-6, B14262F-12-4, B14250F-5-1, and B14250F-11-4. Thus, to obtain the N tolerant lines, selection at a low N environment was more effective compared with the optimum selection environment.
Categorization of temocillin susceptibility using the disc diffusion method: Susceptible, Intermediate, Resistant or Undetermined?
Authors: HENRY Amandine , Michaud Anthony , Degand Nicolas , Bille Emmanuelle , Fournier Damien , Capitaine Agathe , Brun Cecile Le , Lourtet-Hascoët Julie , Guillard Thomas , Corvec Stéphane , Plouzeau-Jayle Chloé , Guillotel Elena , Farfour Eric
Published: January 2020

Background: Since the pandemic of ESBL (extended-spectrum beta-lactamases) and the emergence of carbapenemase-producing Enterobacterales there is a renewed interest in temocillin. However, as the molecule was little used, except in Belgium and UK, there are few guidelines for its antibiotic susceptibility testing (AST). We aim to assess the accuracy of the disc diffusion method (DDM) for temocillin susceptibility testing. Methods: Eight hundred eighty-eight Enterobacterales clinical strains of which 61.7% were resistant to 3 rd generation cephalosporin (3GC-R) were included. AST was performed using DDM in comparison to gradient strip tests (GST) and interpreted using the diameter breakpoint of 20mm and MIC breakpoint of 8 mg/L for DDM and GST as recommended by EUCAST-CASFM recommandations. Results: At breakpoint of 8mg/L, temocillin rates of susceptibility were 76.9%, 95.6% and 67.7% for overall, 3GC-S and 3GC-R strains respectively. Ninety-four (10.6%) discrepancies were noticed including 68 (72.3%) major errors and 26 (27.6%) very major errors. Sixty-eight (72.3%) of all errors correspond to inhibition diameters comprised between 17 and 23 mm. The presence of colonies within the inhibition diameter was noticed for 32 (5.3%) strains susceptible to temocillin. Conclusions: DDM lacks accuracy for strains displaying borderline inhibition zone diameter. We suggest applying the concept of area of technical uncertainty (ATU) for standard DDM. The strains displaying a diameter within the ATU should be tested by another method. The significance of colonies within the inhibition zone diameter should be explored.
Root exudate input stimulates peatland recalcitrant DOC decomposition by r-strategic taxa of Gammaproteobacteria and Bacteroidetes
Authors: Mastný Jiří , Bárta Jiří , Kaštovská Eva , Picek Tomáš
Published: January 2020

Background In peatlands, decomposition of organic matter is limited by harsh environmental conditions and low decomposability of the plant material. Increased microbial decomposition of organic matter in peatland ecosystems may become an important phenomenon in the near future after the expected shift in plant community composition from Sphagnum to vascular plants due to climate change. Such a change in plant community composition will lead to increased root exudates flux to the soil and stimulation of microbial growth and activity. The aim of our study was to evaluate the effect of root exudates on the decomposition of recalcitrant dissolved organic carbon (DOC) and identify the microorganisms responsible for this process. Results Decomposition of recalcitrant DOC was stimulated by a high levels of 13 C labelled root exudates addition whereas it was suppressed by a low levels of root exudates addition. Recalcitrant DOC decomposition was positively related to the exudate C/N ratio as a result of enhanced “microbial nutrient mining” due to a deepening of microbial nutrient limitation. The early stage of incubation immediately following the exudate addition was characterized by the preferential use of the added compounds at the expense of recalcitrant DOC. At the same time, r-strategic bacteria (identification based on average 16SrRNA gene copy number) belonging to mainly to Gammaproteobacteria and Bacteriodete s phyla relatively increased within the microbial community. At the later stage, this more abundant bacterial community was replaced by a less abundant community composed of bacteria mostly belonging to Alphaproteobacteria and Acidobacteria . The most important taxa with the potential to decompose complex compounds were indentified: Mucilaginibacter ( Bacteriodete s), Burkholderia and Pseudomonas ( Gammaproteobacteria ) among r-strategists and Bryocella and Candidatus Solibacter ( Acidobacteria ) among K-strategists. Conclusions Increased inputs of root exudates, with a higher C/N ratio, may stimulate decomposition of peatland recalcitrant DOC. In this, bacteria were found to be more important than fungi. Our experiment indicates that r-strategic bacteria as well as K-strategists can be important in stimulated decomposing of recalcitrant peatland DOC.
MALAT1 plays important role in MEK inhibitor, RG7420, on the proliferation and migration of endometrial cancer cell through sponging miR-129-5p/ TAK1
Authors: Shen Yuan , Mengjun Shan , LU Lin , Ding Xiaomin , Sun Yuanjue , Zhang Jianjun , He Aina , Wang Yaling , Zhou Yan , Su Yang , Yin Junyi , Shen Zan , Yao Yang , Li Ruiman , Hu Haiyan
Published: January 2020

Background: Endometrial cancer is one of the most common malignancies of the female genital tract. Although the overall five-year survival of EC is much higher than other genital tumor, 25% of the total patients with high risk to develop more aggressive diseases. The metastasis in EC patients is the main cause of death. The MEK inhibitor, which has significant effect on malignant molenoma, lung cancer and so on, has bright future in EC. Method: Here we treated the EC cell line HEC50 and HEC1A with different concentration of RG7420. The CCK8 was used to detecte the cell proliferation rate. Microarray analyzed the difference of LncRNAs in EC cells with or without RG7420. Luciferase reporter assay and RNA immunoprecipitation assay(RIP) were performed to verified the regulation among MALAT1, miR-129-5p and TGF-β-activated kinase 1 (TAK1). QRT-PCR and WB were used to detect the changes in mRNA and protein levels. We also performed ISH to detect the MALAT level in EC paraffin section. Results: We found the RG7420 significantly inhibited the viability and mobility of EC cell lines. Then we analyzed the profile of LncRNA in HEC50 with or without RG7420. We found after treated with IC50 of HEC50, the metastasis-associated lung adenocarcinoma transcript-1(MALAT1) decreased 6.13 times with up-regulation of tumor suppressor miR-129-5p. Our data also provided that MALAT1 may work as endogenous sponge for miR-129-5p. Here we predicted and proved TGF-β-activated kinase 1 (TAK1), encoded by MAP3K7, is the target of miR-129-5p and works as the key factor in metastasis of EC. Meanwhile we compared the MALAT1 level in EC paraffin section by in-situ hybridization. Rerospective analysis assessed the corelation between the MALAT1 level and the clinical characters of EC, MALAT1 is a poor prognostic marker of EC. Furthermore we over-expressed MALAT1 in EC cells, the function of RG7420 was reversed. Conclusion: Taken together, our data uncovered RG7420 inhibited the proliferation and migration of EC cell through MALAT1/miR-129-5p/TAK1 pathway. MALAT1 is a poor prognostic marker of EC.