bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterisation of the impact induced damage in composites by cross-comparison among experimental non-destructive evaluation techniques and numerical simulations
Authors: Riccio A , Saputo S , Sellitto A , Lopresto V
Published: November 2016

Composite fibre-reinforced materials, under low velocity impacts, can experience simultaneous interacting failure phenomena, such as intra-laminar damage, fibre breakage and matrix cracking, and inter-laminar damage such as delaminations. These failure mechanisms are usually the subject of extensive investigations because they can cause a significant reduction in strength of composites structures leading to premature failure. In the present work, composite plates under low velocity impact are investigated. Experimental data, such as experimental curves and images from non-destructive inspections, are used to characterise the low velocity impacts-induced damage in conjunction with a non-linear explicit Finite element numerical model. The adopted numerical model, implemented in the FE code (Abaqus/Explicit) by a user-defined material subroutine (VUMAT), has been demonstrated to be very effective in predicting the damage onset and evolution and, in general, able to correctly integrate the experimental data by providing useful information about the impact damage localisation and evolution.
A stochastic model for the estimation of renewal periods of sharply curved metro rails
Authors: Bai Wenfei , Liu Rengkui , Sun Quanxin , Wang Futian , Xu Peng
Published: November 2016

Rail wear is the most common defect that affects sharply curved metro rails, thus impacting their renewal periods. This article presents a stochastic model, based on a Weibull distribution, for the estimation of the renewal periods of sharply curved metro rails based on the analysis of the characteristics of rail wear. The model considers several heterogeneous factors to determine their effects on the deterioration process and is shown to be able to estimate the life expectancy of these rails in any wear state, as well as their remaining lives and renewal periods, with respect to these heterogeneous factors. The model is validated by a case study of the Beijing Metro, based on 10 years of rail wear inspection data and heterogeneous factor data of 200 sharp curves.
When science becomes too easy: Science popularization inclines laypeople to underrate their dependence on experts
Authors: Scharrer Lisa , Rupieper Yvonne , Stadtler Marc , Bromme Rainer
Published: November 2016

Science popularization fulfills the important task of making scientific knowledge understandable and accessible for the lay public. However, the simplification of information required to achieve this accessibility may lead to the risk of audiences relying overly strongly on their own epistemic capabilities when making judgments about scientific claims. Moreover, they may underestimate how the division of cognitive labor makes them dependent on experts. This article reports an empirical study demonstrating that this “easiness effect of science popularization” occurs when laypeople read authentic popularized science depictions. After reading popularized articles addressed to a lay audience, laypeople agreed more with the knowledge claims they contained and were more confident in their claim judgments than after reading articles addressed to expert audiences. Implications for communicating scientific knowledge to the general public are discussed.
Simulating a Climate Engineering Crisis
Authors: Matzner Nils , Herrenbrück Robert
Published: November 2016

Background. At the 2015 Paris Agreement to limit global warming to a maximum of 2 degrees, climate activists and researchers began to look for alternative measures. Climate engineering (CE) - the deliberate manipulation of the planetary environment to decelerate climate change - emerges as a possibly effective, albeit risky and conflictual, option.

Aim. This article aims both at simulating a plausible international scenario of negotiation over solar climate engineering deployment, and at utilizing the rules of Model United Nations (MUN) for collaborative learning in a university class. Furthermore, the article intends to provide a framework for simulations about CE that could easily be reproduced.

Method. MUN is an established and well-tested foundation for a simulation with students, including preparation leading up to the simulation and feedback rounds afterwards. We repeated the simulation three times, recorded the sessions as well as the debriefings, and gathered interesting insight by comparing the results.

Result. For our CE simulations, we discovered: 1. Divergent interests (e.g. global north vs global south). 2. Power struggle (e.g. role of the veto powers). 3. Scientific and political ignorance (e.g. decision-making under uncertainty). 4. Risk politics (e.g. trade-offs between climate change risks vs. CE risks).

Conclusion. MUN qualifies well for simulating a CE crisis. However, known lacks in MUN settings (like underrepresentation of non-state actors) must be discussed during the debriefing. These simulations illustrate possible future conflicts over CE without being prescriptive in any way.
Goal-Setting in Educational Video Games
Authors: Nebel Steve , Schneider Sascha , Schledjewski Janine , Rey Günter Daniel
Published: November 2016

Background. The increased usage of educational video games with their strong graphical and technical potential raises the question of how to optimize the instructional elements of gameplay. In this article, the instructional goal was analyzed with the theoretical background of both motivational psychology (goal-setting theory) and cognitive psychology (goal-free effect).

Aim. We compared different goal types within an educational video game specifically produced for this context, using MINECRAFT as a content creation tool.

Method. Within a quantitative, empirical experiment, 87 students divided into three goal groups (specific learning goal, specific performance goal, goal-free condition) played the video game for nearly three hours per test session to gain knowledge about basic elements of computer science and basic electric engineering.

Results. The results show effects of goal-setting on cognitive load and affective measures. Having specific learning goals lowered extraneous and intrinsic cognitive load. Additionally, players following a specific learning goal reported having significantly more fun, indicating the affective impacts of goal-setting.

Conclusions. The outcomes of this study have practical implications for the creation of educational video games and theoretical implications for further work within the field of instructional psychology.
Performance Testing of RREB1, MYB, and CCND1 Fluorescence In Situ Hybridization in Spindle-Cell and Desmoplastic Melanoma Argues for a Two-Step Test Algorithm
Authors: Weissinger Stephanie E. , Frick Manfred , Möller Peter , Horst Basil A. , Lennerz Jochen K.
Published: November 2016

Background. Diagnostic confirmation of spindle-cell melanoma (SM) or desmoplastic melanoma (DM) as a melanoma can be challenging. In conventional melanoma (CM), a recently established fluorescence in situ hybridization (FISH) assay for RREB1, MYB, CCND1 can be helpful. Here, we determined the presence of RREB1, MYB, and CCND1 abnormalities in an SM/DM/mixed cohort. Methods. We assembled 49 cases and performed 3 separate hybridizations for RREB1/MYB/CCND1. We assessed clinical utility in diagnostically challenging cases and performed a cost and turnaround time analysis. Results. With regard to the diagnosis of melanoma, the FISH assay is 76% sensitive (n = 31/41 true positives melanomas) and 88% specific (n = 1/8 false positive desmoplastic nevi). The prevalence of abnormalities in DM is lower (12/19 cases, 63%; P = .03) than in SM (15/18 cases, 83%; P = .27), mixed (4 of 4 cases), or the reported sensitivity in CM (345/411 cases, 84%). The implied genetic differences in DM result in a higher false negative rate in DM (37%). Despite these limitations, when restricted to diagnostically challenging cases (n = 23), the FISH assay and, in particular, RREB1 was able to confirm melanoma in 70% (n = 16/23). Individual probe sensitivities ( RREB1 > MYB > CCND1) and a cost and turnaround time analysis argues for a 2-step test algorithm that reduces the economic impact of FISH testing considerably (~55%; n = 69 vs 123 hybridizations). Conclusion. We propose a step-by-step genetic testing algorithm to support the diagnosis of melanoma in the setting of SM/DM and show that FISH testing is useful in diagnostically challenging cases.
Prognostic value of free light chains lambda and kappa in early multiple sclerosis
Authors: Voortman Margarete M , Stojakovic Tatjana , Pirpamer Lukas , Jehna Margit , Langkammer Christian , Scharnagl Hubert , Reindl Markus , Ropele Stefan , Seifert-Held Thomas , Archelos Juan-Jose , Fuchs Siegrid , Enzinger Christian , Fazekas Franz , Khalil Michael
Published: November 2016

Background:

Cerebrospinal fluid (CSF) immunoglobulin free light chains (FLC) have been suggested as quantitative alternative to oligoclonal bands (OCB) in the diagnosis of multiple sclerosis (MS). However, little is known on their role in predicting clinical and paraclinical disease progression, particularly in early stages.

Objective:

To assess the prognostic value of FLC in OCB-positive patients with clinically isolated syndrome (CIS) suggestive of MS and early MS.

Methods:

We determined FLC kappa (KFLC) and lambda (LFLC) in CSF and serum by nephelometry in 61 patients (CIS ( n = 48), relapsing-remitting multiple sclerosis ( n = 13)) and 60 non-inflammatory neurological controls. Median clinical follow-up time in CIS was 4.8 years (interquartile range (IQR), 1.5–6.5 years). Patients underwent 3T magnetic resonance imaging (MRI) at baseline and follow-up (median time interval, 2.2 years; IQR, 1.0–3.7 years) to determine T2 lesion load (T2LL) and percent brain volume change (PBVC).

Results:

CSF FLC were significantly increased in CIS/MS compared to controls (all p < 0.001). A lower KFLC/LFLC CSF ratio was associated with CIS-clinically definite multiple sclerosis (CDMS) conversion (hazard ratio (HR) = 2.89; 95% confidence interval (CI) = 1.17–7.14; p < 0.05). No correlations were found for FLC variables with T2LL or PBVC.

Conclusion:

Our study confirms increased intrathecal synthesis of FLC in CIS/MS which supports their diagnostic contribution. The KFLC/LFLC CSF ratio appears to have a prognostic value in CIS beyond OCB.
Exploring play in school recess and physical education classes
Authors: Varea Valeria
Published: November 2016

The purpose of this study was to explore children’s play during recess and in physical education (PE) classes from the perspective of Huizinga’s theory of play. Specifically, this study investigated how primary school PE teachers used the concept of play, how it was understood by student participants, and how the participants engaged in the different phases of play during recess. Two groups of Year 3 children from two different schools participated in the study. Observations and unstructured group and individual interviews were used to collect data. The results reveal that PE teachers used the concept of play to propose activities, therefore employing play as a pedagogical tool. Participants engaged in some short breaks during the different parts of the PE class, during which they engaged in a ludic mode of play. Finally, the players communicated with each other in different ways while playing in a ludic mode during recess, using verbal and non-verbal communication and a combination of both. The results suggest that PE teachers need to determine which approaches to play are more appropriate to use in their classes.
A mixed-methods investigation of psychological factors relevant to weight maintenance
Authors: Dibb-Smith Amanda Ellen , Brindal Emily , Chapman Janine , Noakes Manny
Published: November 2016

This study investigated perceptions of and engagement with the concepts of planning and problem-solving, within a weight management sample. A total of 53 participants (62% female, 20–74 years old) completed a semi-structured interview and quantitative measures after a 16-week weight maintenance period. Preliminary weight maintainers (who had maintained losses of, at least 10% of their original weight) were compared with heavier-than-baseline participants (who had re-gained more weight than was originally lost). The maintainers exhibited stronger problem-solving skills ( p < .05). The heavier-than-baseline participants tended towards non-rational problem-solving styles. Qualitatively, the maintainers described more planning events and were more accepting of mistakes than the heavier-than-baseline participants. Implications are discussed.
‘If you are empathetic you care about both animals and people. I am a nurse and I don’t like to see suffering anywhere’: Findings from 103 healthcare professionals on attitudes to animal experimentation
Authors: Dignon Andrée
Published: November 2016

This report presents qualitative and quantitative data from 103 UK healthcare professionals describing attitudes to the current system of animal testing (to produce medicines and health interventions). To gather qualitative testimony, these healthcare professionals were organised into six separate focus groups (of 18, 17, 17, 15, 17 and 19 participants) where they were asked ‘what is your opinion about the current system of animal testing?’ The study focussed on attitudes to the current system rather than attitudes to animal testing in general. The healthcare professionals also completed a quantitative attitude scale questionnaire consisting of 20 statements (all favourable) towards the system of animal testing as currently practised. Statements such as ‘Testing agencies abide by legislation to safeguard animal welfare’ were displayed and the healthcare professionals were invited to agree or disagree with these statements. The results from both the quantitative and qualitative data suggest that healthcare professionals were opposed to the current system of animal experimentation.
Representations of health, illness and care by Eastern European, South American and Italian nurses: A qualitative study
Authors: Velotti Patrizia , Pace Cecilia Serena , Petrocchi Chiara , Zavattini Giulio Cesare
Published: November 2016

This qualitative study analyses the social representations of health, illness and care, considering the similarities and differences between 30 nurses from different regions. We conducted three intra-ethnic focus groups and two inter-ethnic focus groups. This study shows similarities between the nurses’ representations. All participants believed that the psychological sphere affects individual’s health, that disease is an imbalance between physical and psychological factors and that interpersonal aspects are essential for care. Differences emerged regarding many facets. Eastern European nurses placed more importance on psychological aspects, South American nurses emphasised interpersonal relationships and Italian nurses focused their attention on economic aspects and their impact on health, illness and care.
When do individuals with autism spectrum disorder show superiority in visual search?
Authors: Shirama Aya , Kato Nobumasa , Kashino Makio
Published: November 2016

Although superior visual search skills have been repeatedly reported for individuals with autism spectrum disorder, the underlying mechanisms remain controversial. To specify the locus where individuals with autism spectrum disorder excel in visual search, we compared the performance of autism spectrum disorder adults and healthy controls in briefly presented search tasks, where the search display was replaced by a noise mask at a stimulus-mask asynchrony of 160 ms to interfere with a serial search process while bottom-up visual processing remains intact. We found that participants with autism spectrum disorder show faster overall reaction times regardless of the number of stimuli and the presence of a target with higher accuracy than controls in a luminance and shape conjunction search task as well as a hard feature search task where the target feature information was ineffective in prioritizing likely target stimuli. In addition, the analysis of target eccentricity illustrated that the autism spectrum disorder group has better target discriminability regardless of target eccentricity, suggesting that the autism spectrum disorder advantage does not derive from a reduced crowding effect, which is known to be enhanced with increasing retinal eccentricity. The findings suggest that individuals with autism spectrum disorder excel in non-search processes, especially in the simultaneous discrimination of multiple visual stimuli.
Sex differences in the reciprocal behaviour of children with autism
Authors: Backer van Ommeren Tineke , Koot Hans M , Scheeren Anke M , Begeer Sander
Published: November 2016

Differences in the social limitations of girls compared to boys on the autism spectrum are still poorly understood. Impaired social-emotional reciprocity is a core diagnostic criterion for an autism spectrum disorder. This study compares sex differences in reciprocal behaviour in children with autism spectrum disorder (32 girls, 114 boys) and in typically developing children (24 girls, 55 boys). While children with autism spectrum disorder showed clear limitations in reciprocal behaviour compared to typically developing children, sex differences were found only in the autism spectrum disorder group: girls with autism spectrum disorder had higher reciprocity scores than boys with autism spectrum disorder. However, compared to typically developing girls, girls with autism spectrum disorder showed subtle differences in reciprocal behaviour. The sex-specific response patterns in autism spectrum disorder can inform and improve the diagnostic assessment of autism in females.
Quantifying and exploring camouflaging in men and women with autism
Authors: Lai Meng-Chuan , Lombardo Michael V , Ruigrok Amber NV , Chakrabarti Bhismadev , Auyeung Bonnie , Szatmari Peter , Happé Francesca , Baron-Cohen Simon ,   MRC AIMS Consortium
Published: November 2016

Autobiographical descriptions and clinician observations suggest that some individuals with autism, particularly females, ‘camouflage’ their social communication difficulties, which may require considerable cognitive effort and lead to increased stress, anxiety and depression. Using data from 60 age- and IQ-matched men and women with autism (without intellectual disability), we operationalized camouflaging in adults with autism for the first time as the quantitative discrepancy between the person’s ‘external’ behavioural presentation in social–interpersonal contexts (measured by the Autism Diagnostic Observation Schedule) and the person’s ‘internal’ status (dispositional traits measured by the Autism Spectrum Quotient and social cognitive capability measured by the ‘Reading the Mind in the Eyes’ Test). We found that the operationalized camouflaging measure was not significantly correlated with age or IQ. On average, women with autism had higher camouflaging scores than men with autism (Cohen’s d = 0.98), with substantial variability in both groups. Greater camouflaging was associated with more depressive symptoms in men and better signal-detection sensitivity in women with autism. The neuroanatomical association with camouflaging score was largely sex/gender-dependent and significant only in women: from reverse inference, the most correlated cognitive terms were about emotion and memory. The underlying constructs, measurement, mechanisms, consequences and heterogeneity of camouflaging in autism warrant further investigation.
The art of camouflage: Gender differences in the social behaviors of girls and boys with autism spectrum disorder
Authors: Dean Michelle , Harwood Robin , Kasari Connie
Published: November 2016

This study examined the extent to which gender-related social behaviors help girls with autism spectrum disorder to seemingly mask their symptoms. Using concurrent mixed methods, we examined the social behaviors of 96 elementary school children during recess (autism spectrum disorder = 24 girls and 24 boys, typically developing = 24 girls and 24 boys). Children with autism spectrum disorder had average intelligence (IQ ⩾ 70), a confirmed diagnosis, and were educated in the general education classroom. Typically developing children were matched by sex, age, and city of residence to children with autism spectrum disorder. The results indicate that the female social landscape supports the camouflage hypothesis; girls with autism spectrum disorder used compensatory behaviors, such as staying in close proximately to peers and weaving in and out of activities, which appeared to mask their social challenges. Comparatively, the male landscape made it easier to detect the social challenges of boys with autism spectrum disorder. Typically developing boys tended to play organized games; boys with autism spectrum disorder tended to play alone. The results highlight a male bias in our perception of autism spectrum disorder. If practitioners look for social isolation on the playground when identifying children with social challenges, then our findings suggest that girls with autism spectrum disorder will continue to be left unidentified.
Maritime environmental performance indicators for urban waterways in Amsterdam
Authors: Jacobs FAG , Visser K , Stapersma D
Published: November 2016

Owing to new regulations starting from 2025, all commercial canal boats have to comply to zero local emission standards in Amsterdam. It is therefore vital that a clear emission indicator is made available for vessels with a varying operational profile, such as canal boats. In this paper, it is argued that current indicators, such as the Energy Efficiency Design Index, are not suitable for these (passenger) vessels. This paper proposes environmental performance indicators that can quantify emissions, (non-dimensional) energy and fuel usage based on an operational profile set in the design phase. This profile includes part load operation and auxiliary consumers and it can compare new designed concepts with current baseline vessels based on the ‘benefit for society’ of different vessel types. In the proposed environmental performance indicators, several operational modes can be defined, in contrast with the currently proposed Energy Efficiency Design Index, which is a point index at 75% of installed power. To gauge not only local emissions but also global emissions, the environmental performance indicator methodology is used to determine a minimum efficiency from any power generation method. This minimum efficiency follows from a comparison between baseline vessels and concepts that are more energy efficient and emission friendly. The proposed environmental performance indicators were validated using measurements on typical propulsion configurations of canal boats in Amsterdam. Three full electric concepts were designed and compared with the measured baseline vessels. As full electric concepts do not have local emissions, the method of power generation must satisfy the requirement to have less global emissions than the mechanical baseline. Furthermore, an energy efficiency of at least 33% is calculated from a fossil-fuelled land-based power plant (including transport) to the boundary from quay to boat to be required for newly designed electric concepts to be more energy efficient than the mechanical baseline.
Psychology Student Experience of a Brief, Interprofessional Team Training
Authors: Zucchero Reneé A.
Published: November 2016

Healthcare providers, including psychologists who work as health service providers and with older adults, must be able to work effectively with professionals from other disciplines. Interprofessional education (IPE) engages students from two or more professions to learn collaboratively. To date, only a few studies have examined psychology student involvement in IPE. This article describes the experience of clinical psychology (Psy.D.) doctoral students ( N = 59) who attended a brief, interprofessional (IP) team training. Results of paired-samples t-tests suggest that there was an increase in self-reported positive attitudes about healthcare teams and skills related to working in IP teams from pretest to posttest. Hence, the training may facilitate the development of attitudes necessary for interprofessional competency and provide an opportunity to practice skills central to IP collaboration and team work which are essential for psychologists working in today’s healthcare environment. This experience may serve as a model for psychology programs seeking to expose students to brief, IP, team-based learning.
The Roles of Police Officers in Schools
Authors: Devlin Deanna N. , Gottfredson Denise C.
Published: November 2016

Deploying police officers, known as school resource officers (SROs), in schools is a popular school crime prevention strategy. This study tested whether specific SRO roles, rather than the presence or absence of SROs, influenced school crime and reporting of crimes to law enforcement differently. Specifically, schools with officers serving a law enforcement only role as well as those with officers who also teach and/or mentor (“mixed SROs”), were compared with schools without officers. The study used a longitudinal sample ( N = 480) from the School Survey on Crime and Safety for the years 2004, 2006, and 2008. Results suggest that the level of crime recording and reporting generally increased with SRO presence. Further, schools with law enforcement only SROs recorded more crimes than non-SRO schools, and contrary to hypotheses, schools with mixed SROs reported more crimes to law enforcement. Future research should expand on the typology of SROs used in this study.
Through a Shot Glass, Darkly: The Study of Games in the Light of Drinking Games
Authors: Sotamaa Olli , Stenros Jaakko
Published: November 2016

Drinking games have a history several millennia long. Yet the global community of game scholars has barely touched drinking and games, leaving the area for researchers of health and safety issues. This article is a think piece that approaches drinking games as games and as play, ponders what the study of games can learn from drinking games, weighs what is at stake in them, and connects them to discussions in contemporary game studies relating to materiality, modding, and criticism of the idealization of play.
No Way Out: Severely Abused Latina Women, Patriarchal Terrorism, and Self-Help Homicide
Authors: Harper Shannon B.
Published: November 2016

This article explores the diminished occurrence of intimate partner homicide (IPH)—referred to as self-help homicide—perpetrated by Latinas when compared with Black and White women. Self-help homicide is a consequence of patriarchal terrorism. I endeavor to answer the following research question: What explains lower rates of self-help homicide perpetrated by Latinas relative to White and Black women? This question is addressed through a self-help/intersectional theoretical analysis of structural, institutional, and cultural barriers to criminal justice resource access. This diminished access increases the likelihood of IPH victimization.
Abductor Digiti Minimi Flap for Vascularized Coverage in the Surgical Management of Complex Regional Pain Syndrome Following Carpal Tunnel Release
Authors: Cheung Kevin , Klausmeyer Melissa A. , Jupiter Jesse B.
Published: November 2016

Background: The development of Complex Regional Pain Syndrome (CRPS) represents a potentially devastating complication following carpal tunnel release. In the presence of a suspected incomplete release of the transverse carpal ligament or direct injury to the median nerve, neurolysis as well as nerve coverage to prevent recurrent scar has been shown to be effective. Methods: Retrospective chart review and telephone interview was conducted for patients who underwent abductor digiti minimi flap coverage and neurolysis of the median nerve for CRPS following carpal tunnel release. Results: Fourteen wrists in 12 patients were reviewed. Mean patient age was 64 years (range, 49-83 years), and the mean follow-up was 44 months. Carpal tunnel outcome instrument scores were 47.4 ± 6.8 preoperatively and 27.1 ± 10.6 at follow-up ( P < .001). Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) scores at follow-up were 29.4 ± 26. No significant postoperative complications were identified. Conclusions: The abductor digiti minimi flap is a reliable option with minimal donor site morbidity. It provides predictable coverage when treating CRPS following carpal tunnel syndrome.
Leadership, leadership development and all that jazz
Authors: Harrison Richard T
Published: November 2016

This article critiques key elements of contemporary leadership theory and practice, notably the persistent modernist emphasis on heroic individualism in models of the leader and leadership and the highly instrumental and performative nature of the competence approach to leadership development. Against this, the article draws on the history of jazz as an improvisational art form to develop a view of leadership based on fluidity and adaptability, commitment, creativity and change, community and team enabling and the idea of mastery and wisdom. Leadership-as-practice, in this view, is “collective coherent thinking” based on a lifetime of preparation for exploring the spaces between the notes where creative interpretation meets and responds to uncertainty and unpredictability.
Consistent sex-dependent effects of PKMζ gene ablation and pharmacological inhibition on the maintenance of referred pain
Authors: Nasir Hibatulnaseer , Mahboubi Hicham , Gyawali Sandeep , Ding Stephanie , Mickeviciute Aiste , Ragavendran J Vaigunda , Laferrière André , Stochaj Ursula , Coderre Terence J
Published: November 2016

Background

Persistently active PKMζ has been implicated in maintaining spinal nociceptive sensitization that underlies pain hypersensitivity. However, evidence for PKMζ in the maintenance of pain hypersensitivity comes exclusively from short-term studies in males using pharmacological agents of questionable selectivity. The present study examines the contribution of PKMζ to long-lasting allodynia associated with neuropathic, inflammatory, or referred visceral and muscle pain in males and females using pharmacological inhibition or genetic ablation.

Results

Pharmacological inhibition or genetic ablation of PKMζ reduced mild formalin pain and slowly developing contralateral allodynia in nerve-injured rats, but not moderate formalin pain or ipsilateral allodynia in models of neuropathic and inflammatory pain. Pharmacological inhibition or genetic ablation of PKMζ also effectively reduced referred visceral and muscle pain in male, but not in female mice and rats.

Conclusion

We show pharmacological inhibition and genetic ablation of PKMζ consistently attenuate long-lasting pain hypersensitivity. However, differential effects in models of referred versus inflammatory and neuropathic pain, and in males versus females, highlight the roles of afferent input-dependent masking and sex differences in the maintenance of pain hypersensitivity.
Acute endovascular treatment delivery to ischemic stroke patients transferred within a telestroke network: a retrospective observational study
Authors: Barlinn Jessica , Gerber Johannes , Barlinn Kristian , Pallesen Lars-Peder , Siepmann Timo , Zerna Charlotte , Wojciechowski Claudia , Puetz Volker , von Kummer Rüdiger , Reichmann Heinz , Linn Jennifer , Bodechtel Ulf
Published: November 2016

Background

Five randomized controlled trials recently demonstrated efficacy of endovascular treatment in acute ischemic stroke. Telestroke networks can improve stroke care in rural areas but their role in patients undergoing endovascular treatment is unknown.

Aim

We compared clinical outcomes of endovascular treatment between anterior circulation stroke patients transferred after teleconsultation and those directly admitted to a tertiary stroke center.

Methods

Data derived from consecutive patients with intracranial large vessel occlusion who underwent endovascular treatment from January 2010 to December 2014 at our tertiary stroke center. We compared baseline characteristics, onset-to-treatment times, symptomatic intracranial hemorrhage, in-hospital mortality, reperfusion (modified Treatment in Cerebral Infarction 2b/3), and favorable functional outcome (modified Rankin scale ≤ 2) at discharge between patients transferred from spoke hospitals and those directly admitted.

Results

We studied 151 patients who underwent emergent endovascular treatment for anterior circulation stroke: median age 70 years (interquartile range, 62–75); 55% men; median National Institutes of Health Stroke Scale score 15 (12–20). Of these, 48 (31.8%) patients were transferred after teleconsultation and 103 (68.2%) were primarily admitted to our emergency department. Transferred patients were younger (p = 0.020), received more frequently intravenous tissue plasminogen activator (p = 0.008), had prolonged time from stroke onset to endovascular treatment initiation (p < 0.0001) and tended to have lower rates of symptomatic intracranial hemorrhage (4.2% vs. 11.7%; p = 0.227) and mortality (8.3% vs. 22.6%; p = 0.041) than directly admitted patients. Similar rates of reperfusion (56.2% vs. 61.2%; p = 0.567) and favorable functional outcome (18.8% vs. 13.7%; p = 0.470) were observed in telestroke patients and those who were directly admitted.

Conclusions

Telestroke networks may enable delivery of endovascular treatment to selected ischemic stroke patients transferred from remote hospitals that is equitable to patients admitted directly to tertiary hospitals.
A case study of likely wild-type cardiac transthyretin amyloidosis causing rapid deterioration
Authors: Davies Thomas , Saleh Aarash , Coghlan Gerry , Whelan Carol , Agarwal Banwari
Published: November 2016

We present the case of an 88-year-old gentleman who presented to hospital septic with bilateral leg cellulitis, pulmonary oedema and hypotension. He had no history of heart disease but had had bilateral carpal tunnel releases. His condition deteriorated with refractory hypotension in spite of fluid filling, inotropic and vasopressor support. His echocardiogram showed an infiltrative cardiomyopathy with a speckled myocardium, severe concentric left and right ventricular increased wall thickness, diastolic dysfunction, biatrial dilatation and restrictive physiology in keeping with cardiac amyloidosis. He developed atrial fibrillation and worsening respiratory failure due to fluid overload and was intubated and ventilated but continued to decline and passed away. The degree of heart failure in the absence of ischaemia, the patient’s advanced age, echocardiographic findings and past history of carpal tunnel syndrome in a male are strongly indicative of a diagnosis of wild-type cardiac transthyretin amyloidosis. We discuss the key features and intensive care management of this disease.
Comparing dietary patterns derived by two methods and their associations with obesity in Polish girls aged 13–21 years: the cross-sectional GEBaHealth study
Authors: Wadolowska Lidia , Kowalkowska Joanna , Czarnocinska Jolanta , Jezewska-Zychowicz Marzena , Babicz-Zielinska Ewa
Published: November 2016

Aims:

To compare dietary patterns (DPs) derived by two methods and their assessment as a factor of obesity in girls aged 13–21 years.

Methods:

Data from a cross-sectional study conducted among the representative sample of Polish females ( n = 1,107) aged 13–21 years were used. Subjects were randomly selected. Dietary information was collected using three short-validated food frequency questionnaires (FFQs) regarding fibre intake, fat intake and overall food intake variety. DPs were identified by two methods: a priori approach (a priori DPs) and cluster analysis (data-driven DPs). The association between obesity and DPs and three single dietary characteristics was examined using multiple logistic regression analysis.

Results:

Four data-driven DPs were obtained: ‘Low-fat-Low-fibre-Low-varied’ (21.2%), ‘Low-fibre’ (29.1%), ‘Low-fat’ (25.0%) and ‘High-fat-Varied’ (24.7%). Three a priori DPs were pre-defined: ‘Non-healthy’ (16.6%), ‘Neither-pro-healthy-nor-non-healthy’ (79.1%) and ‘Pro-healthy’ (4.3%). Girls with ‘Low-fibre’ DP were less likely to have central obesity (adjusted odds ratio (OR) = 0.36; 95% confidence interval (CI): 0.17, 0.75) than girls with ‘Low-fat-Low-fibre-Low-varied’ DP (reference group, OR = 1.00). No significant associations were found between a priori DPs and overweight including obesity or central obesity. The majority of girls with ‘Non-healthy’ DP were also classified as ‘Low-fibre’ DP in the total sample, in girls with overweight including obesity and in girls with central obesity (81.7%, 80.6% and 87.3%, respectively), while most girls with ‘Pro-healthy’ DP were classified as ‘Low-fat’ DP (67.8%, 87.6% and 52.1%, respectively).

Conclusion:

We found that the a priori approach as well as cluster analysis can be used to derive opposite health-oriented DPs in Polish females. Both methods have provided disappointing outcomes in explaining the association between obesity and DPs. The cluster analysis, in comparison with the a priori approach, was more useful for finding any relationship between DPs and central obesity. Our study highlighted the importance of method used to derive DPs in exploring associations between diet and obesity.
Psychological consequences of traumatic upper limb peripheral nerve injury: A systematic review
Authors: Miller Caroline , Peek Aimie L , Power Dominic , Heneghan Nicola R
Published: November 2016

Introduction

Traumatic upper limb peripheral nerve injuries significantly impact individuals’ function and ability to return to work. Patients with peripheral nerve injury experience ongoing psychological impairments for which they are not routinely treated. The aim of this review was to investigate the psychological consequences of traumatic upper limb peripheral nerve injury.

Methods

A systematic review of MEDLINE, Embase, PsycINFO, CINAHL, AMED, BNI, the Cochrane libraries and grey literature up to October 2015 was undertaken. Two reviewers independently assessed methodological quality in accordance with Cochrane Collaboration recommendations. Eligibility criteria comprised: adults or adolescents with traumatic upper limb peripheral nerve injury using any measurement of psychological well-being.

Results

Six studies ( n = 245) met the inclusion criteria. Methodological quality varied widely. Evidence of post-traumatic stress disorder at one month, which decreased over time, was reported in three studies. Two studies found a statistically significant correlation between the early presence of post-traumatic stress disorder and reduction in function at 12 or more months. Limited information was available on anxiety, depression and mental quality of life. Combined nerve injuries (in two studies) had significantly higher levels of post-traumatic stress disorder, at one month, compared to those with an isolated nerve injury.

Conclusion

There is some evidence of early post-traumatic stress disorder following traumatic upper limb peripheral nerve injury, which may have an impact on functional outcome. However, high-quality studies using prospective cohorts are required to further evaluate the psychological aspects associated with this traumatic injury.
Sweet’s syndrome associated with clonal hematopoiesis of indeterminate potential responsive to 5-azacitidine
Authors: Yaghmour George , Wiedower Eric , Yaghmour Bassam , Nunnery Sara , Duncavage Eric , Martin Mike G.
Published: November 2016

Sweet’s syndrome (SS) is a rare condition characterized by the abrupt appearance of painful skin lesions due to neutrophilic dermal infiltration. Hematologic neoplasms, particularly acute myeloid leukemia (AML) and myelodysplastic syndromes (MDSs), have been commonly reported in association with SS. Clonal hematopoiesis of indeterminate potential (CHIP) is an emerging entity that is a precursor state to myeloid neoplasms. CHIP has not been previously associated with SS.

We report the case of a 71-year-old man who presented with recurrent, painful edematous and erythematous papules and nodules for 18 months despite treatment with corticosteroids. He had normal blood counts, but a macrocytosis was noted (110 fl). Alternative causes of macrocytosis were ruled out. A skin biopsy confirmed a diagnosis of SS. Bone marrow biopsy specimen yielded a normal karyotype except for loss of the Y chromosome and equivocal morphologic findings. Polymerase chain reaction (PCR) and reverse transcription polymerase chain reaction (RT-PCR) of selected genes from the peripheral blood demonstrated a mixed lineage leukemia (MLL) partial tandem duplication (PTD) and sequence variant in CCAAT/enhancer binding protein alpha (CEBPA). These findings were consistent with a diagnosis of CHIP. The patient was treated with 5-azacitidine and achieved a complete remission of his skin lesions and was able to discontinue corticosteroids.

To our knowledge, this is the first report of a patient with recurrent SS associated with CHIP. In addition to other myeloid neoplasms like AML and MDS, CHIP should be considered as a potential etiology in cases of recurrent SS. Treatment with a hypomethylating agents such as azacitidine could also serve as an alternative to systemic corticosteroid therapy.
From Mogi to Pokémon GO: Continuities and change in location-aware collection games
Authors: Licoppe Christian
Published: November 2016

We compare here some features of the emerging uses of Pokémon GO with earlier, though less successful, location-aware collection games such as Mogi. While mobility patterns are relatively similar, Pokémon GO brings about a distinctive augmented-reality dimension to the game experience, though it does not harness the social networking power of such location-aware game platforms to the same extent as earlier games.
Improving cardiovascular outcomes among Aboriginal Australians: Lessons from research for primary care
Authors: Thompson Sandra C , Haynes Emma , Woods John A , Bessarab Dawn C , Dimer Lynette A , Wood Marianne M , Sanfilippo Frank M , Hamilton Sandra J , Katzenellenbogen Judith M
Published: November 2016

Background:

The Aboriginal people of Australia have much poorer health and social indicators and a substantial life expectancy gap compared to other Australians, with premature cardiovascular disease a major contributor to poorer health. This article draws on research undertaken to examine cardiovascular disparities and focuses on ways in which primary care practitioners can contribute to reducing cardiovascular disparities and improving Aboriginal health.

Methods:

The overall research utilised mixed methods and included data analysis, interviews and group processes which included Aboriginal people, service providers and policymakers. Workshop discussions to identify barriers and what works were recorded by notes and on whiteboards, then distilled and circulated to participants and other stakeholders to refine and validate information. Additional engagement occurred through circulation of draft material and further discussions. This report distils the lessons for primary care practitioners to improve outcomes through management that is attentive to the needs of Aboriginal people.

Results:

Aspects of primordial, primary and secondary prevention are identified, with practical strategies for intervention summarised. The premature onset and high incidence of Aboriginal cardiovascular disease make prevention imperative and require that primary care practitioners understand and work to address the social underpinnings of poor health. Doctors are well placed to reinforce the importance of healthy lifestyle at all visits to involve the family and to reduce barriers which impede early care seeking. Ensuring better information for Aboriginal patients and better integrated care for patients who frequently have complex needs and multi-morbidities will also improve care outcomes.

Conclusion:

Primary care practitioners have an important role in improving Aboriginal cardiovascular care outcomes. It is essential that they recognise the special needs of their Aboriginal patients and work at multiple levels both outside and inside the clinic for prevention and management of disease. A toolkit of proactive and holistic opportunities for interventions is proposed.
A practical validation study of a commercial accelerometer using good and poor sleepers
Authors: Dickinson David L , Cazier Joseph , Cech Thomas
Published: November 2016

We validated a Fitbit sleep tracking device against typical research-use actigraphy across four nights on 38 young adults. Fitbit devices overestimated sleep and were less sensitive to differences compared to the Actiwatch, but nevertheless captured 88 (poor sleepers) to 98 percent (good sleepers) of Actiwatch estimated sleep time changes. Bland–Altman analysis shows that the average difference between device measurements can be sizable. We therefore do not recommend the Fitbit device when accurate point estimates are important. However, when qualitative impacts are of interest (e.g. the effect of an intervention), then the Fitbit device should at least correctly identify the effect’s sign.
Virtual carers for the elderly: A case study review of ethical responsibilities
Authors: Garner Tom A , Powell Wendy A , Carr Valerie
Published: November 2016

Intelligent digital healthcare systems are becoming an increasingly considered approach to facilitating continued support of our ageing population. Within the remit of such digital systems, ‘Virtual Carer’ is one of the more consistent terms that refers to an artificial system capable of providing various assistive living and communicative functionalities, embodied within a graphical avatar displayed on a screen. As part of the RITA (Responsive Interactive Advocate) project – a proof of concept for one such virtual carer system – a series of semi-structured discussions with various stakeholders was conducted. This paper presents the results of these discussions to highlight data security, replacement of human/physical care and always acting in the user’s best interest. These three ethical concerns and designer responsibilities are identified as highly relevant to both individuals and groups that may, in the future, utilise a system like RITA either as a care receiver or provider. This paper also presents some initial, theoretical safeguard processes relevant to these key concerns.
Anti–Herpes Simplex Virus Type-1 Activity and Phenolic Content of Crude Ethanol Extract and Four Corresponding Fractions of Quercus brantii L Acorn
Authors: Karimi Ali , Rafieian-Kopaei Mahmoud , Moradi Mohammad-Taghi , Alidadi Somayeh
Published: November 2016

This research was aimed to evaluate anti–herpes simplex virus type-1 (anti-HSV-1) activity of crude ethanol extract and 4 corresponding fractions of Quercus brantii acorn in vitro. Crude ethanol extract was prepared and subjected to fractionation with different polarity. Anti-HSV-1 activity was evaluated on baby hamster kidney cell line using MTT assay. The inhibitory effect of the plant materials on adsorption and/or post-adsorption stages of HSV-1 replication cycle were determined. Regression analysis was used to determine 50% inhibitory concentration and 50% cytotoxicity concentration, from which selective index was calculated. Based on our results, the chloroform fraction and the crude extract had the highest effect against HSV-1 with selectivity indices of 53.8 and 48.4, respectively. The n-hexane, n-butanol, and chloroform fractions inhibited HSV-1 replication in postadsorption stage ( P < .001). The results obtained indicated that the chloroform fraction of Q brantii acorn with high inhibitory effect against HSV-1 replication could be a new promising anti-HSV-1 agent.
Book Review: Ramesh Chandra Kalita, Agrarian Unrest in Assam
Authors: Farooqui Amar
Published: November 2016

Ramesh Chandra Kalita, Agrarian Unrest in Assam (Dispur: Ulopi Publications), 2014, 226 pp., ₹500 (hardback).