bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advancement in Synthesis and Bioactivities of 1,3,4-Oxadiazole
Authors: Chaudhary Tarun , Upadhyay Prabhat Kumar
Published: December 2022

Derivatives of 1,3,4-oxadiazole are effective in the treatment and cure of a wide range
of diseases in medical chemistry, while industrial development has shown that they can be utilised
as corrosion inhibitors and light-emitting diodes. The researchers discovered several promising
synthetic strategies that created 1,3,4-oxadiazoles in extraordinarily high yields while using environmentally
friendly methods. These compounds can potentially be used in a wide range of lifechanging
applications. Stable isomeric oxadiazole forms of pleconaril, raltegravir, butalamine,
fasiplon, oxolamine, and several other drugs are among the numerous potent and effective pharmaceuticals
that are now on the market. Fasiplon, butalamine, raltegravir, and pleconaril treat
HIV/AIDS patients. This article has attempted to bring attention to the chemistry and pharmacology
of oxadiazole and its derivatives. Oxadiazole derivatives have been used extensively as prospective
therapeutic agents in clinical research, and this has become standard practice. The use of biological
and in-silico models has enabled scientists to identify more synthetic analogues of cancer prevention,
antifungal, and anti-HIV medications. This article provides recent information regarding procedures
for synthesizing 1,3,4-oxadiazoles and their biological actions on the body.
RBC Membrane-coated Nanoparticles: A Comprehensive Review on the Preparation Methods, Characterisations and Applications
Authors: Sammour Rana M.F. , Almardod Zainab A. , Alkayed Amira I.M. , Makhashen Marwa G.B. , Sbahi Tasneem M.H. , Ahmed Alaa I.M. , Albacha Rasha F.
Published: December 2022

Natural cells have become an area of interest due to their biocompatibility, nonimmunogenicity, biodegradability, and targeting specificity. The human vascular system retains distinctive physiological features that can be developed for enhanced and effective targeted drug delivery. Red blood cells (RBCs) have unique features and properties that make them potential natural carriers for numerous substances. Recently, the RBC membrane has become a unique biological carrier and it has been extensively studied due to its long-circulating half-life, low toxicity, high stability and the ability to transport various biologically active substances with higher drug release efficiency. Among the benefits of the RBC membrane as a drug delivery carrier in medical and biological fields is the use of this system in anticancer therapy. Antitumor drugs are loaded in gold NP, magnetic NPs, or mesoporous silica NPs. Then, the loaded NP is used as a core and coated with an RBC membrane to protect the NP from immune attack and enhance drug targeting. Moreover, RBCs have been used for encapsulating different enzymes to overcome the undesirable outcomes associated with enzyme replacement therapy. This review highlighted the most recent RBC membrane preparation methods, such as Membrane coating technology and Osmotic Loading Procedures. The recent advances in the design of RBC membrane carriers and discuss the applications of RBCs in different fields such as therapeutic enzymes, immunotherapy and anti-tumour therapy. Given the potential risks and challenges in the development of any treatment protocol, this review elucidated the problematic aspects and prospects, describing new modalities to overcome these problems. RBCs as a drug carriers are among the most interesting topics as a novel drug delivery system as they are convenient, effective, safer, biocompatible and have good properties to deliver and administrate the drug specifically to the target site of action with fewer side effects and interference with therapeutic aspects.
Distributed Ledger Technology and its Potential Applications - Financial Sector
Authors: Sharma Sachin , Kumar Kamal
Published: December 2022

The concept of blockchain has shown tremendous potential and growth in
the last decade. The terms such as blockchain and digital ledger technology are used
interchangeably. Many research efforts have been madto explain and harness the
benefits of digital ledger technology for the financial sector. Digital currency or
cryptocurrency is a technological currency based on the block chain concept.
Hydroponics Monitoring System Based on IoT and Blockchain
Authors: Singh Bedi Harpreet , Gupta Raghav , Sindhwani Manoj , Kumar Sharma Kamal
Published: December 2022

Since blockchain is the central technology of bitcoin, block chain has gained
a lot of attention in recent years. Its applications are expanding in a variety of fields,
including Internet of Things (IoT) defense, banking, industries, and medical centre.
Furthermore, IoT has grown in popularity because of its widespread usage in smart
homes and urban developments around the world. This paper presents the design of an
automated system for a greenhouse focusing mainly on Hydroponics. Along with the
design, the purpose of this study is monitoring, control, and visualization of the data.
This project addresses some of the issues in traditional farming. Issues like incapability
of agriculture due to small and fragmented land holdings, risk in using manures and
pesticides, and lack of mechanization. The segments of this project include the main
module (referred to as AGMS), the cloud, and the end user. The data visualization is
done through a website that will acquire it from a Wi-Fi module through APIs. The
study also includes social media alerts to platforms like Twitter and mail.
Safety and Effectiveness of Intravitreal Dexamethasone Implant (Ozurdex®) for the Treatment of Refractory Cystoid Macular Oedema (CMO) in Galway University Hospital
Authors: Tang Bobby , Yeow Casserene E. Shen , Harney Fiona , Townley Deirdre
Published: December 2022

Aim:

The aim of this study is to assess the real-life effectiveness and safety of intravitreal Ozurdex in an Irish setting.

Background:

Ozurdex is an intravitreal dexamethasone implant that is used for the treatment of macular oedema secondary to retinal vein occlusion and diabetic macular oedema.

Methods:

This was a retrospective observational study of adult patients in University Hospital Galway who received an intravitreal dexamethasone implant (Ozurdex) for the treatment of cystoid macular oedema secondary to diabetic eye disease or retinal vein occlusion. The main outcome was the mean change in best-corrected visual acuity 3-6 months after the treatment.

Results and Discussion:

36 patients were included in the study. Overall, there was a 1.66 mean letter gain (SD 11.8) 3-6 months post-treatment. The proportion of patients who gained >10 letters was 15.6%. The mean reduction in CST was 110.6um (SD 255.7), and in the linear regression analysis, no variables were found to be significantly associated with a change in visual acuity. In terms of adverse events, 14.3% of patients had significant cataract progression and 20.6% of patients had a significant rise in IOP following intravitreal Ozurdex implant.

Conclusion:

Intravitreal Ozurdex was found to be safe and effective, supporting it as an appropriate second-line treatment in patients with refractory macular oedema secondary to diabetic eye disease and retinal vein occlusion. Further studies should be carried out to evaluate the possible predictors of visual acuity outcome.
Governo eletrónico Brasil e Portugal as limitações na aplicabilidade da comunicação interativa cidadã.
Authors: Nogueira Junior Dario Azevedo
Published: December 2022

From the analysis of consolidated data such as: Index of Digitality of the Economy and Society of the European Commission, National Institute of Statistics, Internet Management Committee in Brazil, Digital In, Brazilian Institute of Geography and Statistics, Fundação Getúlio Vargas, among other sources, this article aims to contribute tothe academic debate, trying to trace a correlation in the pattern adopted in electronic public policies applied to the Brazilian and Portuguese reality. Starting from the aspect of how these governments are thinking about the use of the internet and its relationship with the restrictions of citizen digital interactivity in the sense of understanding how they see forming a thought in relation to the use of the internet by these governments, and their adherence to the concept of New Management Public (NGP)
Hubungan self awareness dengan disiplin belajar peserta Asesmen Kompetensi Minimum (AKM) SD Negeri Gugus 01 Kecamatan Ngawi
Authors: Septianingtias Arina , Herwin Herwin
Published: December 2022

Penelitian ini bertujuan untuk mengetahui hubungan self awareness dengan disiplin belajar peserta AKM SD Negeri Gugus 01 Kecamatan Ngawi. Penelitian ini menggunakan pendekatan kuantitatif dengan metode ex-post facto. Populasi dalam penelitian ini adalah peserta AKM SD Negeri Gugus 01 Kecamatan Ngawi pada tahun 2021 sebanyak 120 siswa dengan sampel penelitian berjumlah 92 siswa yang ditentukan menggunakan rumus Slovin. Teknik pengumpulan data menggunakan kuesioner dengan pengukuran skala likert. Instrumen pengumpulan data menggunakan skala self awareness dan disiplin belajar. Teknik analisis data dalam penelitian ini menggunakan analisis statistik deskriptif dan korelasi sederhana. Hasil penelitian menunjukkan bahwa terdapat hubungan yang positif dan signifikan antara self awareness dengan disiplin belajar peserta AKM SD Negeri Gugus 01 Kecamatan Ngawi yang dibuktikan dengan nilai koefisien korelasi sebesar 0,859 bernilai positif dengan nilai sig. (2-tailed) sebesar 0,000. Tingkat hubungan yang dimiliki variabel self awareness dengan variabel disiplin belajar adalah sangat kuat.Kata kunci: Asesmen kompetensi minimum, self awareness, disiplin belajar
Značenje multidisciplinarnog tima u rehabilitaciji osoba koje su preboljele COVID -19
Authors: Bobek Dubravka , Aksentijević Jan , Schnurrer-Luke-Vrbanić Tea , Zahirović Nino
Published: December 2022

COVID-19 multisistemska je bolest koja, iako dominantno utječe na dišni sustav, može zahvatiti gotovo svaki organski sustav te zahtijeva strukturiranu rehabilitaciju koju provodi multidiciplinarni tim. Akutna, rana, rehabilitacija tijekom prvih 30 dana od infekcije čini tek prvu fazu rehabilitacije osoba oboljelih od bolesti COVID-19. Simptomi i znakovi fizičkih, neurokognitivnih i psihičkih posljedica nakon infekcije virusom SARS-CoV2 mogu trajati tjednima ili mjesecima nakon kraja akutne faze bolesti, a mogu se razviti i u osoba koje su imale blagu kliničku sliku i nisu bile hospitalizirane. Najčešći simptomi i znakovi koji se javljaju nakon akutne faze bolesti COVID-19 jesu umor, zaduha, kašalj, bol u zglobovima i mišićima te nesanica i pojačani efluvij kose. Bolesnici čije je kliničko stanje u akutnoj fazi bolesti zahtijevalo liječenje mehaničkom ventilacijom, mogu imati dugotrajne posljedice uključujući fizičku slabost i neurokognitivnu disfunkciju (brain fog) obilježenu gubitkom intelektualnih funkcija poput koncentracije i kratkoročnog pamćenja. Bolesnici s kognitivnom disfunkcijom imaju problema s prisjećanjem riječi, diskalkulijom i koncentracijom. Rehabilitacijski program Post-COVID dnevne bolnice za fizikalnu medicinu i rehabilitaciju provodi multidisciplinarni tim koji je fokusiran na cjelokupno funkcioniranje bolesnika, a ne samo na ledirani organ ili organski sustav, uključujući posljedice bolesti COVID-19 te moguće komplikacije liječenja i komorbiditete. Cilj rehabilitacije bolesnika u razdoblju poslije COVID-a jest postizanje potpunog funkcionalnog oporavka i adekvatne kvalitete života.
Rehabilitacija osoba nakon moždanog udara
Authors: Laktašić Žerjavić Nadica , Slivar Luka , Perić Porin
Published: December 2022

Moždani udar, iako nastupa naglo, u svojoj biti je kronično stanje. Morbiditet i mortalitet od moždanog udara i dalje su vrlo visoki, a onima koji su preživjeli moždani udar, u pravilu, potrebna je akutna bolnička skrb koja se zatim nastavlja kroz subakutnu rehabilitaciju i, u konačnici, reintegraciju u zajednicu. Rehabilitacija se provodi timskim interdisciplinarnim pristupom. Usprkos uloženim naporima, još uvijek postoji mnogo nezadovoljenih potreba preživjelih koji su doživjeli moždani udar, počevši od dostupnosti akutne bolničke skrbi, potom dostupnosti i organizacije subakutne rehabilitacije te, u konačnici, od mogućnosti reintegracije u zajednicu. Rehabilitacija bi trebala započeti tijekom akutne bolničke skrbi unutar prvih 24 do 48 sati kroz ranu mobilizaciju bolesnika. U subakutnoj fazi ishod rehabilitacije izravno ovisi o broju sati dnevno provedenih u rehabilitacijskom programu. Za uspješan ishod rehabilitacije važno je individualno procijeniti oštećenje i funkciju pomoću specifičnih mjernih instrumenata, postaviti individualizirane ciljeve i sukladno tome izraditi plan rehabilitacije te pratiti učinkovitost rehabilitacijskog programa. Primarni je cilj rehabilitacije uspostavljanje samostalnosti u obavljanju aktivnosti svakodnevnog života. U članku su pregledno prikazani tijek rehabilitacije nakon moždanog udara, primarna i sekundarna oštećenja tjelesnih funkcija i struktura nakon moždanog udara, kao i ograničenja aktivnosti koja iz njih proizlaze, te osnovni principi njihove rehabilitacije.
Neurorehabilitacija oboljelih od Parkinsonove bolesti nakon ugradnje duboke mozgovne stimulacije
Authors: Rožmarić Gloria , Rački Valentino , Mašić Marijan , Vuletić Vladimira
Published: December 2022

Duboka mozgovna stimulacija (DBS) vodeća je kirurška metoda u liječenju bolesnika s uznapredovanom Parkinsonovom bolešću (PD). Neurorehabilitacijom nakon ugradnje DBS uređaja nastoji se oboljelima omogućiti normalno funkcioniranje u svakodnevnim interakcijama i aktivnostima te na taj način unaprijediti kvalitetu života. U procesu neurorehabilitacije sudjeluje multidisciplinarni tim koji čine neurolog, fizioterapeut i logoped. Uloga neurologa u ovome procesu je prilagođavanje parametara DBS uređaja te prilagodba farmakološke terapije. Uloga fizioterapeuta je održavanje i obnavljanje maksimalne funkcionalne pokretljivosti i sposobnosti, dok je uloga logopeda terapija poremećaja govora na koji DBS ima specifičan utjecaj.
Sindrom tarzalnog tunela
Authors: Skala Kavanagh Hana , Balen Diana , Nemčić Tomislav
Published: December 2022

Sindrom tarzalnog tunela (STT) relativno je rijetka kompresivna mononeuropatija donjih ekstremiteta uzrokovana kompresijom tibijalnog živca ili njegovih ogranaka (medijalnog ili lateralnog plantarnog živca) u području tarzalnog kanala. Pripada skupini kanalikularnih sindroma, a iako puno rjeđi, može se smatrati ekvivalentnim sindromu karpalnog tunela. Klinički se očituje pojavom boli, poglavito u medijalnom dijelu tabana te žarenjem i trncima u području prva tri prsta stopala. Uz kliničku procjenu, za dijagnosticiranje ove neuropatije najčešće se koriste elektrodijagnostičke pretrage – elektroneurografija (ENG) i elektromiografija (EMG), te ultrazvučna pretraga. Liječenje STT-a može biti konzervativno i kirurško. Konzervativno liječenje preporučuje se bolesnicima s lakšim do umjerenim tegobama, dok se kirurško liječenje provodi u bolesnika s težim oštećenjima. Cilj je ovog preglednog rada prikazati novije spoznaje vezane za STT s naglaskom na potvrdu kliničke dijagnoze najčešće korištenim dijagnostičkim pretragama kao što su elektroneurografija (ENG) i elektromiografija (EMG) te ultrazvučni pregled.
Software-Based Simulation on a 3D Environment for Vaccination Teaching and Learning: Design Science Research
Authors: Domingueti Daniel , Barbosa Feres Carvalho Darlinton , Colombo Dias Diego Roberto , Oliveira Valéria Conceição
Published: December 2022

Background

Student training requires specific laboratories for vaccination practice, which are usually limited, and even professionals’ continuing education regularly lacks proper care. Thus, new methodologies, concepts, and technologies, such as software-based simulations, are in highly demand.

Objective

This work aims to develop a 3D virtual environment to support teaching activities in the vaccination room. The software-based simulation must contribute positively to teaching considering a variable set of scenarios.

Methods

We applied the design science research method to guide the work. First, the concepts and opportunities were raised, which we used to build the simulation (ie, the proposed technological artifact). The development was assisted by a specialist, in which we sought to create a vaccination room according to Brazilian standards. The artifact evaluation was achieved in 2 stages: (1) an evaluation to validate the design with experts through the Delphi method; and (2) a field evaluation with nursing students to validate aspects of usability (System Usability Scale [SUS]) and technology acceptance and use (Unified Theory of Acceptance and Use of Technology version 2).

Results

We built the simulation software using the Unity game engine. An additional module was also developed to create simulation scenarios and view the students’ performance reports. The design evaluation showed that the proposed solution is adequate. Students’ evaluations confirm good usability (SUS score of 81.4), besides highlighting Performance Expectation as the most positively influential factor of Behavioral Intention. Effort Expectancy is positively affected by younger users. Both evaluation audiences cited the high relevance of the proposed artifact for teaching. Points for improvement are also reported.

Conclusions

The research accomplished its goal of creating a software-based simulation to support teaching scenarios in the vaccination room. The evaluations still reveal desirable improvements and user behavior toward this kind of technological artifact.
Monkeypox content on TikTok: a cross-sectional analysis (Preprint)
Authors: Ji-Xu Antonio , Htet Kyaw Zin , Leslie Kieron S
Published: December 2022

UNSTRUCTURED

Approximately 81,000 monkeypox cases have been confirmed globally during the ongoing 2022 outbreak. Online and social media platforms can help disseminate up-to-date information on monkeypox but can also cause patient harm by propagating misinformation. TikTok is currently the most downloaded app globally, with >1 billion monthly active users. However, there have been no studies investigating the quality of monkeypox content on TikTok. Hence, our aim was to analyze popular monkeypox content on TikTok to assess metrics affecting user engagement and content quality. TikTok was searched for videos using the term “monkeypox” on August 27, 2022. Metadata and content quality were assessed by two independent reviewers using DISCERN, a validated 16-item instrument to evaluate quality of health information scored from 1 (poor) to 5 (excellent). The mean DISCERN score was 2.8 (standard deviation [SD]=1.0), with high interrater reliability (Cohen’s kappa >0.8). Physician videos had a significantly higher mean DISCERN score (4.0) and lesser variation in scores (SD=0.5) compared to non-physician videos (mean DISCERN=2.1, SD=1.0; p<0.00001). Low DISCERN scores were most common on items involving sources of information and treatment choices. Only one video mentioned tecovirimat, and no videos mentioned vaccinia immune globulin, cidofovir or brincidofovir. Our findings highlight the potential for physicians to reduce monkeypox misinformation on TikTok. Physician creators posting monkeypox content on TikTok should consider including discussion of treatments and using hashtags selectively to increase user engagement.
Herpes-associated erythema multiforme in a postmenopausal woman
Authors: Susanto Hendri , Nurhilailah Nurhilailah , Ganesha Raziv , Hendarti Hening Tuti , Hadi Priyo
Published: December 2022

Herpes-associated erythema multiforme (HAEM) is an acute inflammatory mucocutaneous disease which is characterized by ulcerative lesion on oral mucous membrane with or without skin involvements. The etiology of erythema multiforme (EM) is probably hypersensitivity reaction to human herpes simplex virus tipe 1 (HSV-1). Lesions on lips with HAEM can be treated by corticosteroid and acyclovir topically and/or orally. The objective of this study wasto report the case of HAEM with painful ulcers accompanying with crust on lips. A 55 years old woman complained painful ulcers with crust on lips since the last five months. She had visited a primary health care service and received several medications such as antibiotic (ciprofloxacin), anti-inflammatory drug (corticosteroid), analgesic (mefenamic acid) but her complaint was never healed completely because it was always recurring. The lesion on her lips got worse when she ate hot and spicy food and after she went out for outdor activities. She had a history of herpes virus infection seven months before but it was completely healed after treated by acyclovir topically and amoxicilin orally. An extra oral examination found black brown crust on her upper lip vermillion, well-demarcated, irregular margin, rough surface, erythematous surrounding area, accompanied with pain. An intra oral examination identified ulcers, yellowish, 4-5 mm in size, well-demarcated, irregular margin, redness in surronding area, accompanied with pain. Acomplete blood count examination, serology test for HSV-1 (IgM and IgG) were taken and the result showed that only IgG was reactive. The therapies given to the patient were topical medications with a combination of corticosteroid, chloramphenicol and moisturizer, followed by methyl prednisolone and acyclovir orally. After 6-week treatment, the lesions were completely healed.Herpes-associated erythema multiforme (HAEM) caused by hypersensitivity reactionto herpes simplex virus type 1 (HSV-1) may have a characteristic of painful ulcers accompanied with crust on the lips. The combination of both anti-inflammatory and antiviral drugs can be a choice for the therapy.
Oral health-related quality of life in type 2 diabetic patients of Yogyakarta General Hospital
Authors: Agustina Dewi , Purwanti Nunuk , Hanindriyo Lisdrianto , Naritasari Fimma
Published: December 2022

Yogyakarta is a province in Indonesia with the highest prevalence (2.4%) of Diabetes Mellitus (DM). Around 90% of diabetic patients suffer from type 2 DM. Oral manifestations of DM may disturb oral functions which in turn influence oral health - related quality of life (OHRQo)L. This study aimed to evaluate the OHRQoL of type 2 DM outpatients in Yogyakarta General Hospital. The study subjects comprised 50 male outpatients and 32 female outpatients with type 2 DM (40-81 years old). Geriatric Oral Health Assessment Index (GOHAI) and Xerostomia Inventory were used to assess OHRQoL and xerostomia status, respectively. Intraoral examinations comprising periodontal tissue, oral hygiene (OH), coated tongue, and present teeth were performed. There were 49 (59.76%) subjects with low and 33 (40.24%) subjects with high score of GOHAI; 78 (95.12%) with and 4 (4.88%) without periodontal tissue defect; 79 (96.34%) with poor and 3 (3.66%) good OH; 17 (20.73%) with coated tongue >50% and 65 (79.27%) with coated tongue ≤50%; 34 (41.46%) with present teeth <20 and 48 (58.54%) with present teeth ≥20; and 39 (47.56%) with xerostomia and 43 (52.44%) with normal status. Only ‘present teeth’ had a significant contribution to the proportion of GOHAI status in type 2 DM patients in this study (p=0.032). Type 2 DM patients with ≥20 teeth had a more significant proportion of high GOHAI status compared to those with <20 teeth. The majority of type 2 DM outpatients of Yogyakarta General Hospital had poor OHRQoL as reflection of their oral condition that is partly contributed by patients with present teeth <20.
Effect of advanced-platelet rich-fibrin combined with rosuvastatin application after open flap debridement of infrabony pocket
Authors: Rahadianti Tissa , Herawati Dahlia , Murdiastuti Kwartarini
Published: December 2022

Open flap debridement (OFD) is an invasive therapy for chronic periodontitis with pocket 5 mm or more. However, it is difficult to achieve regeneration and new attachment with this therapy. Periodontitis starts to add growth factors and local drugs delivery as host modulation therapy. Advanced-PRF (A-PRF) contains more growth factor than PRF which plays a role in promoting fibroblast proliferation, reepithelization, extracellular matrix production, and endothelial cell migration. 1.2% rosuvastatin gel (RSV) is a local delivery drug with a pleiotropic effect that can modify host response to promoting BMSCs, BMP-2, OPG, ALP, RANKL, and osteoblasts. This study aimed to examine the effect of the application of A-PRF+RSV in OFD therapy of which the parameters were probing depth (PD), relative attachment loss (RAL), and alveolar bone height. The study samples consisted of 24 periodontal pockets which were divided into 2 groups of 12 pockets each, namely A-PRF+RSV for group 1 and PRF+RSV for group 2. Clinical evaluations were carried out on baseline, day-30, and day-90 for PD and RAL, and on baseline and day -90 for alveolar bone height. Data of PD and RAL reduction were analyzed with non-parametric test Mann-Withney, while data of reduction of alveolar bone height were analyzed with parametric Independent-T test. Group 1 obtained a statistically more significant result in reducing PD, RAL, and alveolar bone height compared to group 2 (p<0.05) To conclude, the application of A-PRF and 1.2% rosuvastatin gel in OFD procedure promotes a higher PD and RAL reduction and alveolar bone height increase than the application of PRF coupled with 1.2% rosuvastatin gel.
Effect of Co-Cr alloy recasting on the fracture toughness
Authors: Eka Resti Efrata , Dharmastiti Rini , Widjijono Widjijono
Published: December 2022

Frame denture generally uses Co-Cr alloy. However, alloy is expensive, so dental laboratories use residual sprue casting for recasting. The purpose of this study was to determine the effect of Co-Cr alloy recasting on fracture toughness. This was a laboratory experiment, with five sample groups, namely R0: 100% of new alloys; R1: 50% one-time recasting procedure and 50% new alloys, R2: 50% two-time recasting procedure and 50% new alloys, R3: 50% three-time recasting procedure and 50% new alloys, R4: 50% four-time recasting procedure and 50% new alloys. Fracture toughness was tested using a universal testing machine; the data were analyzed by One-Way Anova test and LSD (p>0.05). The results showed that the fracture toughness was 233.103 MPa-m1/2 in R4, and the highest was 242.435 MPa-m1/2 in R0. The results of the analysis by the LSD test on fracture toughness showed that there were no significant differences in R0 with R1 and R2, but there were significant differences between R0 with R3 and R4. There was a decrease after recasting in each group because of the missing elements of the Co-Cr alloy. The percentage of each element decreased due to oxidation and evaporation during heating. There was a change in the composition of the Co-Cr alloy in R3 and R4. There was a decrease in the fracture toughness. Variation in recasting frequency of Co-Cr alloy affected the fracture toughness. In each sample groups, the fracture toughness of Co-Cr alloy decreased after recasting.
The cariogenic effect of school snack on risk levels with caries assessment tool study in children age 12-15 years old
Authors: Subandari Yulita , Priyono Bambang , Supartinah Al
Published: December 2022

The teen years, around the age of 12-14 years, is the time for children to experience physical growth spurt, which increases their appetite, so they love snacks and develop snack eating habit at school. This study aims to determine the cariogenic effect of school snacks on caries risk based on the caries assessment tool (CAT) study in children aged 12-15 years. This is an observational quantitative study with cross-sectional research design. The population in this study were all students of class VII, aged 12-15 years in SMP Negeri (SMPN) Kulon Progo, comprised of 2,047 students. This study used a cluster proportional random sampling technique and obtained a sample size of 100 respondents. Data were collected using a questionnaire about school snacks and observation of caries risk assessment was based on CAT, and the data were analyzed using the Chi-Square test. The results showed that the cariogenic school snacks consumed by children aged 12-15 years in SMPN Kulon Progo were in the low category (71%); risk of caries occurrence based on CAT studies in children aged 12-15 years was in the high category of 50%. There was no significant effect on cariogenic school snacks on the level of caries risk based on CAT study in children aged 12-15 years.
Educational approaches to improving knowledge and attitude towards dental hygiene among elementary school children
Authors: Prabawati Nenny Wuri , Hanindriyo Lisdrianto , Widiati Sri
Published: December 2022

The selection of appropriate dental health education methods will be beneficial in promoting dental health. This study aimed to determine the difference in the effect of role-playing method and storytelling method on knowledge and attitudes towards oral hygiene among elementary school students. The research subjects were 112 students in grade 5. The subjects were divided into 2 different treatment groups, namely 56 students in grade 5 at SD Negeri Tegalrejo I with the storytelling method and 56 students in grade 5 at SD Negeri Tegalrejo II using the role-playing method. The measuring instrument in this research was a questionnaire. The data analysis used the Mann-Whitney test and Wilcoxon Signed Ranks test because the data were not normally distributed. The results of the analysis showed that there was a significant increase over time in knowledge and attitudes carried out in 3 assessments. The mean rank for delta values between the pre-test and posttest 2 for the knowledge variable using the role-playing method was 51.29 while that using the storytelling method was 61.71. Meanwhile, the mean rank for delta values for the attitude variable using the role-playing method was 49.93, while that using the storytelling method was 63.07. The results of the delta analysis from pre-test to post-test 1 and pre-test to post-test 2 showed that the storytelling group experiences a higher increase in knowledge and attitudes than the role-playing group (p<0.05). Provision of education using a storytelling method shows better improvement in students’ knowledge and attitudes towards oral hygiene than using a role-playing method.
Evaluation on the use of plate positioning guide (PPG) on the placement accuracy of post-hemimandibulectomy plate reconstruction
Authors: Doni Bulfendri , Rahajoe Poerwati Soetji , Widiastuti Maria Goreti
Published: December 2022

Improper placement of the reconstruction plate can lead to postoperative complications. Placing reconstruction plates that have arch for operation is made easier with the plate positioning guide (PPG) as a transfer method of reconstruction plate. This study aimed to assess the impact of PPG on the placement accuracy of reconstruction plate as determined by the symmetrical breadth of the mandibular arch and the consistent placement of reconstruction plate following hemimandibulectomy. According to the inclusion criteria, this was a retrospective cross-sectional study with 12 participants (n = 12) after hemimandibulectomy. Subjects were divided into PPG (n = 6) and Non-PPG (n = 6) groups. Measurement of the difference in the width of the mandibular arch and the height of the placement of the reconstruction plate between the reconstructed and non-resected sides in three positions (anterior, posterior, and angulus) was conducted using submentovertex radiographs and orthopantomogram (OPG) through the RadiAnt DICOM Viewer software. The placement accuracy of the reconstruction plates was analyzed using a one-sample t-test with p-value 0.05. The results showed that the placement accuracy of the reconstruction plate in the PPG group were accurate (p = 0.590), and the Non-PPG group was inaccurate (p = 0.000); with the independent sample test. There was a significant difference between the two groups (p = 0.000). Plate positioning guide provides better symmetry of the mandibular arch width post-hemimandibulectomy.
Osteoporosis detection using radiomorphometric examination and fractal dimensions through cone-beam computed tomography
Authors: Nursari Efie Mariyam , Kiswanjaya Bramma , Priaminiarti Menik , Bachtiar-Iskandar Hanna H
Published: December 2022

Cone-beam computed tomography (CBCT) is becoming more widely used in the field of dentomaxillofacial radiography, but its utility for bone quality assessment is still limited. This study was conducted to describe the use of radiomorphometric examination and fractal dimensions (FDs) for osteoporosis risk detection through CBCT in elderly patients. Medical databases (PubMed, Scopus, Elsevier, and Directory of Open Access Journals (DOAJ)) were searched using the keywords osteoporosis, radiomorphometric, fractal dimension, and fractal analysis. The search limits applied were available full-text articles, publication years 2012-2021, and articles published available in English. Then, the articles included were systematically reviewed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A total of four studies were included in this review. Seven radiomorphometric indices were used, and most indices were adopted from panoramic radiographs, such as the computed tomographycortical index, computed tomography mental index, computed tomography index, and four other indices along the mandible, which are the S (symphysis), A (anterior), M (molar), and P (posterior) indices. All of the radiomorphometric studies show similar results. These indices can identify osteoporosis-related changes and are useful as osteoporosis screening tools on CBCT. However, all FD studies show different methods and discover heterogeneous results. Radiomorphometric measurement methods in CBCT can be used to detect patients at risk for osteoporosis. The FD analysis method still finds heterogeneous research results, so it is recommended to standardize the method in terms of the shape, size, and location of the region of interest.
Relationship between premolar extraction on the dimension of upper airway and tongue posture in skeletal class II malocclusion
Authors: Rangkuti Hartati Zuraidah , Rachmawati Aditya , Sufarnap Erliera
Published: December 2022

Correction of skeletal Class II malocclusion with camouflage orthodontic treatment generally requires the extraction of the maxillary first premolars to provide space for retraction of the maxillary incisors. Retraction of incisors changes the position of the incisors and the dimensions of the dental arch, which can cause changes in tongue posture and affect the upper airway. The purpose of this study was to determine the relationship between premolar extraction on the dimensions of upper airway and tongue posture in skeletal Class II malocclusion. This study was designed as a retrospective cohort using lateral cephalometric radiographs before and after orthodontic treatment. The samples in this study consisted of 44 samples of adult patients (n = 44) aged 18-40 years, who were divided into 2 groups: 22 subjects treated without premolar extraction and 22 subjects treated with premolar extraction. Lateral cephalometric radiographic analysis were used to measure the dimensions of the upper airway by analyzing superior posterior airway space (SPAS), middle airway space (MAS), inferior airway space (IAS), vertical airway length (VAL), and tongue posture (tongue length and height tongue) using imageJ software. No Statistically significant different changes were observed as seen from the following results: SPAS (p = 0.709), MAS (p = 0.365), IAS (p = 0.562), (p = 0.401), tongue length (p = 0.578), tongue height (p = 0.086) in the sample group without extraction premolar. No significant alterations in the upper airway and tongue posture measurement were observed in the sample group with extraction premolar. Premolar extraction with retraction on upper incisors did not affect upper airway dimensions and toung posture in skeletal Class II malocclusion.
The effect of aerosol suction distance during brushing brackets of orthodontic patients on the presence of Streptococcus and Staphylococcus
Authors: Triawan Andi , Lasara Belladina Yusi
Published: December 2022

Dentists are one of the professions most at risk of infection transmission because dental care potentially produces many infectious aerosols for bacterial transmission. Using personal protective equipment and aerosol suction that meets the standards for dentists is vital to prevent cross-infection in patients in practice. This study aims to determine the effect of aerosol suction distance on the orthodontic patient bracket brushing process on total plate number and the presence of Streptococcus and Staphylococcus on the dentist’s face shield. The method used is the swab method on the face shield used by dentists after brushing orthodontic patient brackets with variations in the distance of aerosol suction to the oral cavity of 10 cm, 15 cm, and 20 cm. After 2 x 24 hours of incubation, the total plate count was calculated, and Streptococcus and Staphylococcus were identified by analyzing the characteristics of the growing colonies and executing the catalase test. The results showed that the lowest total plate number found on a face shield with aerosol suction distance of 10 cm from the oral cavity, 1.23 ± 0.01 CFU/cm2. The one-way ANOVA test obtained a significance value of p < 0.05, concluding that the variation of the aerosol suction distance affects the total face shield plate number. The presence of bacteria on the face shield was negative for Streptococcus and positive for Staphylococcus.
EXPLORATION OF THE EFFICACY AND SAFETY OF ORAL MOISTURIZING AGENTS FOR DRY MOUTH AND XEROSTOMIA: A SYSTEMATIC REVIEW
Authors: WICAKSONO IMME KRIS , WAHYUNI INDAH SUASANI
Published: December 2022

This systematic review aimed to explore the efficacy and safety of oral moisturizing agents for dry mouth and xerostomia. Oral moisturizing agents improve the patient's quality of life by moisturizing the oral mucosa and maintaining the buffer capacity. The methods of this review was structured following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Pubmed and Ebscohost-CINAHL Plus databases were used for article searching. The JADAD or Oxford quality scoring system was used to assess the risk of bias. Oral moisturizing agents tested were moisturizer mouthwash, Verramin gel, oral moisturizer jelly (OMJ), GC Dry Mouth Gel®, aloe vera mouthwash, and ginger mouthwash. All of them can reduce discomfort and dry mouth complaints in patients. Even OMJ could increase salivary pH and reduce the risk of candidiasis. There was no significant difference after using moisturizer mouthwash in patients with Sjogren's syndrome compared to giving natural water as a control. Mild to moderate adverse effects were found due to the use of moisturizer mouthwash. Oral moisturizing agents can overcome the problem effectively and safely for dry mouth or xerostomia, however, were less effective for patients with Sjogren's syndrome.
PHARMACOLOGICAL MANAGEMENT OF ORAL LESIONS IN ADENOID CYSTIC CARCINOMA PATIENTS UNDERGOING RADIOTHERAPY
Authors: ROSA DESI ELVHIRA , ADHISTY THEODORA , DEWI TENNY SETIANI
Published: December 2022

Objective: This case report aimed to describe the pharmacological management of oral lesions in adenoid cystic submental carcinoma patients undergoing radiotherapy.

Methods: A 48 y old female undergoing radiotherapy complained of difficulty eating, swallowing, and speaking due to severe pain in her oral cavity for three weeks. Intra-oral examination revealed painful yellowish-white plaques that could not be scrapped on the tongue, maxillary and mandibular anterior gingiva, left and right buccal mucosa, and palate, diagnosed with oral candidiasis. We also found multiple shallow ulcers on the left buccal mucosa and upper labial mucosa that can be seen as oral mucositis.

Results: The patient was given nystatin oral suspension for oral candidiasis, benzydamine hydrochloride for the complaint of pain when swallowing, and saline for promoting wound healing and keeping the oral mucosa moist. These lesions healed in a week and she could eat solid food without pain.

Conclusion: Appropriate pharmacological management of oral lesions in a patient undergoing radiotherapy provides significant healing to better quality of life.
Malware Detection Using Machine Learning and Deep Learning
Authors: Thete Prof. Sharda , Midgule Siddheshwar , Konde Nikesh , Kale Suraj
Published: December 2022

Abstract: Android application security is based on permission-based mechanisms that restrict third-party Android applications' access to critical resources on an Android device. The user must accept a set of permissions required by the application before proceeding with the installation. This process is intended to inform users about the risks of installing and using applications on their devices. However, most of the time, even with a well-understood permission system, users are not fully aware of endangered threats, relying on application stores or the popularity of applications and relying on developers to You are accepting the install without trying to analyze your intent.
4E Strategy for Pedagogical Analysis of Content
Authors: Mishra Yudhisthir , Khamari Miss. Kshireswari
Published: December 2022

Abstract: Pedagogical analysis is based on four essentials pillars along with their inherent mutual relationships and interdependence for being considered essential in the effective teaching-learning process. Content analysis of the topic being taught by the teacher in the subject. Setting of the teaching or instructional objectives of the content material of the topic in hand by writing them in specific behavioral term. Suggesting methods, techniques, teaching-learning activities aids and equipments helpful for the teaching-learning of the topic in hand quite in tone with the realization of the set instructional objectives. Suggesting appropriate evaluation devices in the form of oral, written or practical activities and test questions etc. for evaluating the outcomes of the teaching-learning process carried in relation to the teaching-learning process carried in relation to the teaching of the topic in hand. Researcher developed a strategies for pedagogical analysis of a particular content that is called “4E Strategy”.
Optimization of Injection Molding Process for Kenaf and Polypropylene Composite to Improve Its Tensile Strength
Authors: Yewale Priti , Kulkarni S. R.
Published: December 2022

Abstract: Process parameters directly affect the performance and quality of the composite of polypropylene (PP) and kenaf in injection molding. Optimize the parameter of injection molding with the help of response surface methodology (RSM). The important parameters are injection temperature, pressure, and holding time to optimize using the 3-factor, 3-level Box Behnken method. MINITAB 20 is used for statistical analysis of tensile properties of polypropylene and kenaf composite. In this paper the confirmation test is conducted to verify the predicted value of tensile strength and the results show the optimum value for injection temperature is 191.970°C, a pressure value is 40 bar, and the holding time is 13.8384 sec. the optimum parameters are used to manufacture the composite for better tensile strength and actual value of the composite is in the range of the predicted value.
Survey on Fire Detection Using Image Processing
Authors: Dandge Shrikant
Published: December 2022

Abstract: With rising Urbanisation the frequency of fires has increased. A rapid need exists for quick and effective fire detection. Traditional fire detection systems are utilizing physical sensors to detect fire. Sensors gather information about the chemical characteristics of airborne particles, which traditional fire detection systems then use to generate an alarm. However, it can also result in false alerts; for instance, an ordinary fire alarm system might be triggered by smoking inside a space. Using a computer system based on vision for detecting fire would facilitate rapid and precise detection of fire with the ongoing developments in image processing. A lot of observable improvements have been developed to help a successful fire detection algorithm or model. This paper compiles research on methods that, when used, can effectively detect fire. In addition, a system architecture for fire detection is developed in this study. It suggests many fire detection methods, including Celik, SDD, F-RCNN, R-FCN and YOLOv3. This paper offers a thorough comparison of the same.
Design and Analysis of Gear Bicycle Using Proton Exchange Membrane Fuel Cell (Analysis and MATLAB)
Authors: Magibalan Dr. S. , Gandhiraj S
Published: December 2022

Abstract: The fuel cell is an electrochemical cell is use to fuel to fuel source for automobile application. It is process to chemical energy converts of water vapor. The normally used to fuel source is coal energy, electrical and solar energy. Renewable resources fuel source of the vehicles power. From the literature survey it has been found that “polymer electrolyte membrane fuel cell” (or) “proton exchange membrane fuel cell”. Fuel cells are very useful as renewable power sources in remote location. It is small weight are most suited of transportation application.. The fuel cell is direct current (dc). The proton exchange membrane fuel cell output power is (50-250 kw) . it is low temperature compare to other fuel cell. The PEMFCs so efficiencies vary but most are between 40 % and 60 % energy efficient.
Congestion Management in Deregulated Power System Using Different Control Technique
Authors: Rajora Harshita
Published: December 2022

Abstract: In today’s scenario there is a challenge for power companies to meet the expected demand load due to continuous increases in load demand causes unpredictable failure in the components of power system including transmission line, generator, transformer and various other equipment this leads to over loading in the power system and the line become congested if this failure not removed on time the system reaches to emergency state, therefore we are using various techniques to control or manage these situations these methods includes Generator Rescheduling(GR),Load Shedding, Particle Swarm Optimizer(PSO), Grey Wolf Optimization (GWO),Harmony search algorithm etc. Optimal load shedding is effective control action for congestion management. The various algorithm applied on IEEE 30 bus system.