bluuebunny/crossref_metadata_2025 huggingface dataset:
Diplomacy and tyrannicide: A letter of Robert Cecil, Earl of Salisbury, to Nicholas de Neufville, seigneur de Villeroy (1609)
Authors: Серегина А.Ю. , Шишкин В.В.
Published: October 2023

Публикация представляет неизвестное письмо государственного секретаря Якова I Роберта Сесила, графа Солсбери, своему французскому коллеге Никола де Нёвиллю, сеньору де Виллеруа из Собрания П.П. Дубровского (Санкт-Петербург, Российская национальная библиотека. Авт. 72. № 16). В письмо, написанном в Лондоне 7 (18?) ноября 1609 г., Сесил информировал Виллеруа о готовящемся против французского короля Генриха IV заговоре. К письму должен был прилагаться меморандум с подробным рассказом о заговоре, но он не сохранился. Во вступительной статье реконструирован политический контекст письма, а также установлено имя посла, который привез Сесилу сообщение о заговоре. Им был Джон Барклай, который летом-осенью 1609 г. посетил Северную Италию и Германию; его миссией было преподнести европейским государям посвященный им политический трактат Якова I. Представлена транскрипция письма (на франц. языке) и его русский перевод с комментариями.

The publication presents a previously unknown letter by Robert Cecil, Earl of Salisbury, Secretary of State to King James I of England, to his French colleague, Nicholas de Neufville, seigneur de Villeroy, from the Dubrovsky collection (St Petersburg, Russian National Library, Autograph 72, № 16). The letter was written in London on 7 (18?) November of 1609. Through it, Cecil informed Villeroy that there was a plot to kill King Henry IV of France. The details of the plot were to be provided in a memorandum sent together with the letter; this document has not survived. The introductory article established the political context of the letter. The ambassador of the King of England who brought Cecil the information of the plot has also been identified. This was John Barclay who in the summer and autumn of 1609 visited Northern Italy and Germany; his mission was to present European monarchs with a political tract by King James I dedicated to them. The publication presents the transcription of the letter (in French) and its Russian translation, together with commentaries.
Comparing Vegetation and Substrate Performances on Nutrient Removal and Biomass Establishment Using a Natural Swimming Pool Experiment
Authors: Hoffman Margaret C. , Berghage Robert , Wu Hong
Published: October 2023

Natural swimming pools (NSPs) rely on the interaction of bog vegetation, bacteria, and substrate to maintain water quality. Nitrogen (N) and phosphorus (P) levels in NSPs are critical because of their involvement in eutrophication. We conducted a 15-week greenhouse study to address the significant literature gap regarding nutrient removal capabilities of substrates and vegetation in the low-nutrient environment of NSPs. We used mass balance analyses to compare the performances of four substrates [river gravel (control), recycled glass, expanded clay, expanded shale] and two plant species [blue flag iris (Iris versicolor) and lizard’s tail (Saururus cernuus)] under two flow conditions: free water surface and subsurface flow. At the end of the experiment, except for the recycled glass group, all other substrate groups reduced water nitrate (NO3) levels to less than 30 mg⋅L−1, the standard of the 2011 Forschungsgesellschaft Landschaftsentwicklung Landschaftsbau (FLL) guidelines. However, only the expanded clay group closely approached the P standard (≤0.01 mg⋅L−1). Expanded clay and expanded shale demonstrated potential as substrates for NSP bogs. The final aboveground biomass dry weight was strongly negatively correlated with the final NO3 and P water concentrations. However, direct plant uptake proved insufficient to remove all nutrient inputs, especially for P. Except for the recycled glass group (34%), a significant portion of N (79%–90%) from total N added was removed by aboveground biomass. However, P uptake by biomass was substantially lower (18%–37%). With acceptable vigor and biomass accumulation, blue flag iris may be a suitable species for vegetated NSPs, whereas lizard’s tail is not because of uncertain establishment. Compared with controlling N, managing P for FLL standards in NSPs will be more challenging. Our work begins to fill the essential gap in the NSP literature regarding nutrient removal capabilities of substrates and vegetation. Future work should continue to study alternative substrates and plant species for P removal, particularly in field conditions and over longer periods.
Evaluation of breeding material on the basis of morphological and cytological characteristics of the reproductive organs of plants of the genus Miscanthus
Authors: Lashuk S. O.
Published: October 2023

Purpose. To study in vitro the morphological and cytological characteristics of anthers, pollen and pistils of plants of the genus Miscanthus.
Methods. Preparations of pistils, unpollinated seed buds, anthers and pollen, unstained or stained with a solution of carmine (2%) in acetic acid (45%) or methylene blue solution, were examined by light microscopy. Measurements for plants of different Miscanthus species, as well as counting the number of pollen of different diameters, were made in ten replicates.
Results. The morphologicaland cytological characteristics of the reproductive organs of M. sinensis, M. sacchariflorus and M. giganteus species were studied. It was found that the flower of this plant is monoecious, containing both stamens and a pistil. The color of the anthers is yellow or pinkish-yellow, their tissues consist of elongated cells 70–100 µm long. The pistil has a two-column ovary with long (2.0–2.8 mm) pinnate stigmas which vary in color from white to bright pink. The shape of the pistil feather is moderately branched; length – 160–300 µm; width – 20–30 µm; alternate position; the number of small branches is 10–15 pcs. The pollen of different Miscanthus species differ in qualitative and quantitative characteristics, in particular in M. sinensis and M. sacchariflorus it is characterized by a rounded shape, evenness and uniformity (43–48 µm in diameter), whereas in M. giganteus it is more heterogeneous in size (23–45 µm in diameter). The pollen has a rounded, decorated pore with a diameter of 2.7–4.0 µm.
Conclusions. According to the results of the conducted research, the morphological and cytological characteristics of the reproductive organs of M. sinensis, M. sacchariflorus and M. giganteus, namely: pistils, anthers and pollen, were provided. The data obtained should be taken into account in future breeding for the production of di- and triploid Miscanthus hybrids.
FeCl3-Catalyzed Cross-Coupling for Improving the Synthesis of Upadacitinib
Authors: Li Ziling , Shi Chundiao , Xiang Shengchang , Liu Chulong , Zheng Ximing
Published: October 2023

As an oral Janus kinase 1 inhibitor, upadacitinib shows good activity in the treatment of rheumatoid arthritis, especially for other drug-resistant and refractory rheumatoid arthritis patients. A key step in the synthesis of upadacitinib is the introduction of ethyl on the pyrroline ring. Here, a FeCl3/p-aminophenol catalyst system was used to increase the ethyl introduction for synthesis of pyrroline building blocks of upadaticinib. This catalytic system allows milder reaction conditions and increases the yield of this step by 25% compared to the existing reports, and the scale-up experiment is still effective. In addition, a possible FeII/FeIV catalytic mechanism for this reaction was also proposed.
A GENDERED TAXONOMY ON HOUSING PRECARITY
Authors: Pestana Lages Joana , Jorge Sílvia
Published: October 2023

‘How to stay home?’ is a question that many posed when the COVID-19 pandemic forced us to stay indoors. Housing precariousness is still a problem for circa sixty thousand families in Portugal, to whom escaping poverty, and several types of discrimination is still hard. This paper is based on an action-research project focused on housing precariousness, aiming to build a taxonomy on the different experiences lived by women, under the neoliberal context of the Global North. Starting from 10 in-depth interviews, this paper makes investigates housing precarity from a gendered perspective, identifying the main inequalities before and during the pandemic, as well as the priorities proposed for/from women. The relation between housing and gender is questioned from the way we organize ourselves: socially and spatially. Understanding this relation can be a catalyst to better responses and effective public policies, and more effectively end precarity.
CONJUNTURAS CRÍTICAS LATINO-AMERICANAS E A POLÍTICA DE HABITAÇÃO NA COLÔMBIA
Authors: Christie de Olives Sara Judy , Nascimento Neto Paulo , Arturo Calvache Jorge Armando , Caicedo Medina Julián Alberto
Published: October 2023

O artigo analisa a política habitacional na América Latina, com especial atenção à experiência da Colômbia. Nas últimas décadas, difundiu-se um modelo de produção padronizada de unidades habitacionais, com ênfase no estímulo à demanda e no apoio ao setor da construção civil. Esse modelo tem sido amplamente discutido em países como México, Chile, Colômbia e Brasil. Nesse contexto, a Colômbia se destaca por sua longa história de formulação e implementação de políticas de habitação social (PHS). O artigo analisa a trajetória de institucionalização da PHS colombiana, examinando os momentos críticos e seu impacto na dependência do programa. Além disso, propõe uma nova periodização que explica grandes compartimentos temporais a partir de três modos de restrição utilizados pelas instituições como meios de operação: regras, práticas e narrativas. Em conclusão, o artigo oferece uma perspectiva crítica sobre a política habitacional na América Latina e destaca a experiência da Colômbia como um caso relevante para sua análise a partir da teoria do neo-institucionalismo histórico que ajuda a entender a evolução e as limitações das políticas habitacionais no país e oferece uma base para o desenho de políticas futuras mais eficazes.

Palavras-chave: Política de habitação social, neo-institucionalismo histórico, América Latina e Colômbia.
Doces regionais, identidade e tradição
Authors: Alves Josemery Araújo , Taline Gomes Dantas Juliana
Published: October 2023

O artigo consiste numa análise da gastronomia regional, mais precisamente, com enfoque nas doceiras tradicionais, na cultura e como esse elemento pode se constituir como incitação turística na região do Seridó/RN. Com isso, o objetivo do estudo se qualifica em analisar como a confeitaria regional do Seridó, no Rio Grande do Norte, se constitui como parte da cultura e identidade local. Para tanto, buscou-se captar a visão das doceiras em seus conhecimentos para um resgate histórico e cultural de produção com seus ascendentes e descendentes; identificar a valorização e reconhecimento dos doces na perspectiva da população seridoense, além de visualizar a incitação turística da região e por fim, analisar o potencial dos doces como produto da cultura seridoense, na visão dos idealizadores do “1º Encontro das doceiras do Seridó”. É uma pesquisa qualitativa, de caráter exploratório-descritiva, de forma a examinar as especificidades do objeto de estudo. Os dados foram obtidos por pesquisa bibliográfica e coleta in loco com entrevistas semiestruturadas e questionários. A análise foi feita por representações gráficas e análise dos resultados que indicam que doces como o chouriço e filhós, passados como herança aos atuais doceiros, remetem à memória dos entrevistados, sendo classificados como os que mais representam o Seridó. Conclui-se que os doces da região são tidos como símbolo cultural gastronômico, uma memória que deve ser preservada e valorizada.
Estruturas e equipamentos do modal ferroviário na oferta turística do Maranhão
Authors: Pinho Thays Regina Rodrigues , Da Guia Amanda Leticia Silva , Santos Kauany Cristina Soares dos , Dos Santos Almeida Keila , Frazão Werllem do Nascimento
Published: October 2023

Os elementos ferroviários estão presentes na memória e no cotidiano dos maranhenses e são destacados a partir de sua ressignificância enquanto atrativos turísticos histórico-culturais. O estudo objetiva caracterizar e analisar estruturas do modal ferroviário em uso na oferta turística no Estado do Maranhão, a partir de comentários de viagem online. Com uma abordagem qualitativa, trata-se de uma investigação exploratória e categorial com coleta de depoimentos e avaliações de visitantes em OTRs (Online Travel Reviews), da plataforma Google Maps e Tripadvisor, no período de maio/2019 a outubro/2022. Na análise dos dados, os comentários foram subdivididos em categorias e analisados com a técnica análise de conteúdo. Os resultados apontam que os equipamentos e estruturas férreas são bem avaliados pelos usuários, existindo oportunidades de melhorias, e possuem forte apelo para uso turístico, especialmente quanto à identificação como elementos do patrimônio histórico e memória cultural.
Mercado de trabalho em eventos
Authors: Correa Edilene Vilas Boas Benevides , Silva Rodrigo Cardoso da , Silva Hiago Trindade de Lira
Published: October 2023

O objetivo geral do artigo é analisar a área de eventos do Distrito Federal – DF em termos de porte, relações trabalhistas e precarização do trabalho com destaque para o período pandêmico da Covid-19. O estudo se justifica a partir de três pontos: 1 – Conhecer o setor de eventos do DF. 2 – Identificar relatos dos impactos da pandemia na economia do DF, principalmente no mercado de eventos e seus trabalhadores. 3 – Discutir relações trabalhistas do setor de eventos no DF. A identificação da carência de informações sobre o tema no Brasil e DF, enfatizou a relevância deste trabalho, pois conforme estudo do Sebrae de 2018, o setor representava 4,3% do PIB, gerando 7,5 milhões de empregos diretos e indiretos e ainda assim, trata-se de um campo timidamente estudado. A pesquisa foi dividida em duas partes: A primeira consistiu em realizar pesquisa quantitativa, com análise de dados secundários do IBGE e DATASEBRAE (entre outros) para entender alguns números relevantes sobre o mercado de eventos. A segunda parte, qualitativa, através de entrevistas semiestruturadas com profissionais do setor de eventos do DF. Como resultado da pesquisa ressalta-se que, no contexto da Covid-19, no setor de eventos houve uma expansão do número de empresas e de microempreendedores individuais. Há um movimento de incentivo a abertura de MEI (microempreendedor individual) para substituir o trabalhador de carteira assinada por contratação de CNPJ, alargando a informalidade e precarização no setor, provocando também as baixas remunerações pela subcontratação e direitos limitados aos trabalhadores de eventos.
A AULA DE TEATRO EM TEMPOS PANDÊMICOS
Authors: Benigno Marcelo , Larangeira Telles da Silva Narciso
Published: October 2023

As relações entre A Escola [instituição] e O Teatro [fenômeno artístico] são paradoxais. A partir do contexto pandêmico e da inserção do ensino remoto nas escolas, várias perguntas vieram à tona. Este texto, escrito a quatro mãos por um professor universitário que apresenta algumas premissas do trabalho docente e por um professor da educação básica que reflete sobre uma prática realizada durante o contexto pandêmico na rede pública, apresenta questionamentos para o artistocente.
Comprehensive Investigation of the Influence of High-Altitude Hypoxia on
Clopidogrel Metabolism and Gut Microbiota
Authors: Zhang Juanhong , Sun Yuemei , He Jiaxin , Wu Guofan , Wang Rong , Zhang Junmin
Published: October 2023

Background:

The amount of metabolites converted into active metabolites is correspondingly reduced
since only more than 50% of clopidogrel is absorbed.

Objective:

Exploring the effect of gut microbiota altered by altitude hypoxia on the pre-absorption metabolism of
clopidogrel.

Methods:

In vitro and in vivo experiments were conducted to analyze the metabolism of clopidogrel through LCMS/
MS, while 16S rRNA analysis was used to investigate the changes in the gut microbiota of high-altitude animals.

Results:

We demonstrated that the intestinal flora is involved in the metabolism of clopidogrel through in vivo and
in vitro experiments. In addition, the plateau environment caused changes in the number and composition of intestinal
microbes. Intriguingly, alterations in the microbial population could lead to an increase in the pre-absorption
metabolism of clopidogrel after rapid entry into the plateau, the amount of absorbed blood is thus reduced, which
may affect the bioavailability and therapeutic effect of clopidogrel.

Conclusion:

Our results not only as a first clinical reference for dose adjustment of clopidogrel in high-altitude
environments but also would be helpful to provide a statement on the broader significance within the field of
pharmacokinetics or personalized medicine.
Ultrasound-Assisted Catalyst-Free Knoevenagel Condensation of Carbonyl
Compounds with C – H Acids in Water
Authors: Brahmachari Goutam , Karmakar Indrajit , Mandal Mullicka , Mandal Bhagirath
Published: October 2023

An ultrasound-assisted catalyst-free green protocol has been developed for the synthesis
of a series of diversely substituted Knoevenagel condensation products from the reaction between
functionalized aromatic aldehydes/isatin derivatives and substituted malononitriles as the C-H acids
in water at ambient conditions. The method is simple, straightforward, and highly efficient. The major
advantages of this newly developed protocol are expedient catalyst-free synthesis, good to excellent
yields, energy efficiency, use of water as reaction medium, easy isolation of products, no need
for column chromatographic purification, eco-friendliness, and operational simplicity.
Modulation of the Immune System Mechanisms using Probiotic Bacteria in Allergic Diseases: Focus on Allergic Retinitis and Food Allergies
Authors: Forouhandeh Haleh , Soofiyani Saiedeh Razi , Hosseini Kamran , Minaei Beirami Sohrab , Ahangari Hossein , Moammer Yusif , Ebrahimzadeh Sara , Kashef Nejad Masoomeh , Farjami Afsaneh , Khodaiefar Fariba , Tarhriz Vahideh
Published: October 2023

Allergic illnesses occur when an organism's immune system is excessively responsive to certain antigens, such as those that are presented in the environment. Some people suffer from a wide range of immune system-related illnesses including allergic rhinitis, asthma, food allergies, hay fever, and even anaphylaxis. Immunotherapy and medications are frequently used to treat allergic disorders. The use of probiotics in bacteriotherapy has lately gained interest. Probiotics are essential to human health by modulating the gut microbiota in some ways. Due to probiotics' immunomodulatory properties present in the gut microbiota of all animals, including humans, these bacterial strains can prevent a wide variety of allergic disorders. Probiotic treatment helps allergy patients by decreasing inflammatory cytokines and enhancing intestinal permeability, which is important in the battle against allergy. By altering the balance of Th1 and Th2 immune responses in the intestinal mucosa, probiotics can heal allergic disorders. Numerous studies have shown a correlation between probiotics and a reduced risk of allergy disorders. A wide range of allergic disorders, including atopic dermatitis, asthma, allergic retinitis and food allergies has been proven to benefit from probiotic bacteria. Therefore, the use of probiotics in the treatment of allergic diseases offers a promising perspective. Considering that probiotic intervention in the treatment of diseases is a relatively new field of study, more studies in this regard seem necessary
Racismo, ressentimento e resistência: o baile de Vinicius Junior sobre o recalque espanhol
Authors: Coimbra Gustavo Amaral , Sousa Kátia Menezes de
Published: October 2023

In this work, we propose to analyze the discursive practices of racial exclusion in relation to the black Brazilian athlete Vinicius Junior in European soccer. With this study, we aim to contribute to Foucauldian discursive studies, starting with the explanation of the notion of enuncia-tive function in the analysis of racist discourses, and showing that the statements always point to others that belong to the same enunciate network. To carry out the analysis, we will use, as meth-odological tools, the studies of Discourse Analysis carried out by Michel Foucault, especially the concepts of enunciation, power, and resistance. We will carry out the analyses to verify the presence of discursive regularities of animalization, dehumanization, and demoralization of excluded sub-jects. In addition, we will analyze the materialization of emotions in the statements that make up the discourses of resentment and repression. We will start with the statement that you must respect your opponent. When you score a goal, if you want to dance, go to the Sambadrome in Brazil. Here, what you must do is respect your fellow professionals and stop monkeying around to carry out the proposed checks. This research will result in an understanding of the discursive functioning of the relations of power in which black Brazilian athletes are inserted in European soccer.
Escola Sem Partido and the (real) problems of Brazilian education: an argumentative analysis
Authors: Silva Lucas Pereira da
Published: October 2023

In this article, we aim to discuss about a rhetorical-argumentative strategy of using epistemic argumentative instances to delegitimize the Motivating Circumstances that are constitu-tive of the polemics concerning Escola Sem Partido (ESP). We use a text representative of the posi-tion contrary to the ESP that aims to reframe the Practical Problem concerning the possible needs for action that become relevant in the social sphere of educational practices. For this, we assume the Argumentation Theory, in particular the notions of macrostructure and functional configuration of epistemic argumentation (Toulmin, 2003[1958]; Toulmin; Rieke; Janik, 1984[1978]) and practical argumentation (Fairclough; Fairclough, 2012; Gonçalves-Segundo, 2019). More punctually, we as-sume the studies on Polemics (Amossy, 2016; 2014), Critical Discourse Analysis (Fairclough, 2003; Gonçalves-Segundo, 2018), in addition to the cognitive-functional discussion on Epistemic Posi-tioning (Gonçalves-Segundo, 2020b; Marín-Arrese, 2011). We identified an articulation that, firstly, seeks to question the validity of the reading of the current state of affairs in the discourse of favora-ble positions to the ESP and that, secondly, challenges the Motivating Circumstances that justify the ESP proposal and that fuel controversial dissent. This, in turn, results in an attempt to reframe the Practical Problem, in order to seek to focus on topics and themes considered of paramount impor-tance for the maintenance of an educational system that needs improvement.
O discurso do ex-presidente do Brasil, Bolsonaro, em conflito com a concepção de Estado laico
Authors: Heleno Alex Rezende
Published: October 2023

This article aims to analyze political statements in ex-president Jair Bolsonaro’s dis-course that conflict with the concept of a secular State. From the campaign slogan to the reproduc-tion of a bible verse, the ex-president tends to direct his discourse, of a religious nature, to a conserv-ative and Christian audience, which contributed significantly to his victory in the 2018 elections. This discourse aims to please this part of society, in order to maintain a political base as president and, in 2022, as a candidate for re-election. This analysis is based on theoretical formulations of Dis-course Analysis, exploring the relations between the studies of Pêcheux (ideological formations), Foucault (power relations) and Orlandi, demonstrating the relations between language, subject and historicity present in the discourse. In this way, the ex-president’s discursive intentions to maintain a portion of the electorate can be seen.
Fictiones nelle filosofie medievali e filosofie medievali nelle fictions
Authors: Marmo Costantino
Published: October 2023

This contribution is divided into two independent parts: in the first part, it will deal not so much with examining individual cases of fictio and their role within a certain philosophy or an author, as to see how philosophizing or reasoning through fictiones has been theorized and practiced during the twel-fth and thirteenth centuries; in the second part, it will try, instead, to share what can be found reading medieval setting novels, and in particular medieval crime fiction, namely which image is given of medieval philosophers, philosophies and types of knowledge, and what type of role a wide range of disciplines going from medicine to the arts of trivium play within those narratives
Reflective practice and self-reliance development among nursing students what contribution to academic success?
Authors: El Atmani Zineb , Bellfkih El Mehdi , Madrane Mourad
Published: October 2023

L'étudiant en soins infirmiers parcourt un système d'étude complexe dans un domaine plein de défis. Il est appelé à entreprendre un programme de formation de trois ans qui devrait favoriser une meilleure articulation entre la théorie et la pratique et s'inscrire dans une démarche de professionnalisation, assurant ainsi le développement de son autonomie. Dans un tel contexte, prendre du recul et s'interroger sur la pratique de chacun reste un domaine rarement exploré. Suite à l'implantation de l'approche par compétences, le développement de la pratique réflexive (RP) chez les étudiantes et le besoin de stimuler chez elles l'esprit critique sont une priorité et une condition indispensable à une formation infirmière de qualité. En un mot, le développement d'une démarche réflexive permet à l'étudiant d'avoir la capacité de réfléchir sur les situations rencontrées lors de sa pratique professionnelle.Dans cette perspective, cette étude vise à étudier le développement de la pratique réflexive chez 200 étudiants de 21 ISPITS (Institut Supérieur des Métiers Infirmiers et des Technologies de la Santé) de différents coins du Royaume du Maroc. Elle se fait à l'aide d'un questionnaire dont la validité interne a été validée, envoyé via la plateforme Google Forms. A ce titre, cette étude quantitative portera sur deux aspects dont le premier est descriptif exploratoire pour étudier le niveau de développement de la pratique réflexive dans les ISPITS marocains. La seconde vise à étudier la relation entre la pratique réflexive et le développement de l'autonomie chez les étudiantes infirmières et à vérifier l'existence d'un impact possible sur leur réussite scolaire. Les résultats de cette étude montrent un impact positif de l'importance accordée aux RP dans la formation ISPITS. Aussi,
Value added of teaching factory learning in services production unit to prepare graduate work readiness
Authors: Rosidah Rosidah , Sutirman Sutirman
Published: October 2023

Teaching Factory Learning (TEFA) is a bridge to train students' skills to have work qualifications according to industry needs. The study examined the perspectives of students on TEFA learning in service production units in vocational schools to prepare the graduate work readiness (GWR). Research informants were students of Vocational Schools in the Special Region of Yogyakarta. The research was a qualitative descriptive approach. The data collection techniques were interviews and observations. Then, the collected data were validated using source triangulation. The research showed that students' perspectives on TEFA learning provided added values in 3 domains: 1) knowledge, 2) skills, and 3) Attitudes. Moreover, TEFA learning was able to prepare students to have competencies according to the needs of performance criteria in the industrial world, increase self-confidence and learning motivation, and foster a mental attitude of independence, responsibility, and industrial work culture.
The existence of Malaqbiq Tau Mandar local culture to empower students' educational character of West Sulawesi University
Authors: Ramadhana Nurhikma , Henie Irawati Al Muhdhar Mimien , Sulistijiono Sulistijiono
Published: October 2023

Various studies and facts show that a developed nation is a nation whose character is strong. The integration of local wisdom culture is important to be developed into learning materials because it has a high potential to be utilized in developing the character of students. West Sulawesi Province can be one example. Mandar people living in the province have various cultures and philosophies of cultural diversity which are called the "Malaqbiq tau Mandar". It is a cultural role model and a moral principle for the Mandar people of West Sulawesi. However, as time goes by, the cultural character of Malaqbiq tau Mandar tends to be neglected, especially in the learning process in class. This can be seen in the lack of student. Therefore, this study aims to explore the character education values of Malaqbiq tau Mandar as the basis to develop student character building at the University of West Sulawesi. This study was designed as a qualitative study using an ethnopedagogical approach. Data collection was carried out through interviews, observation, and documentation. Then, the data were analyzed through data reduction, data display, and conclusions. From the results of the study, it was revealed that the Malaqbiq tau Mandar culture contains the following educational values: Malaqbiq pau. Second, Malaqbiq kedzo. Third, Malaqbiq sipaq,and fourth, Malaqbiq gauq (having a good spiritual level and good behavior or morals). In conclusion, Malaqbiq tau Mandar's (MTM) character culture plays an important role in character education. Therefore, its good values should be integrated into the learning process to improve student character.
Teaching genesis of old Turkic alphabet and its connection with Turkic tribe Tamgas
Authors: Sadibekov Аskat К. , Baiymbetova Raushan K. , Myrzakhanova Akbota К. , Yergubekova Zh.S. , Abilova G. , Sadykova A.D.
Published: October 2023

Old Turkic inscription with 2500-years history from the beginning of the 5-4th century A.D., it has been proven that archaeologists have come to prove that European Rune has reached the Turkic steppe.  Every nation in the world has its genealogy, peculiarities and viewpoints. Each nation has its own language, customs, thinking system and value. It is common today that the Old Turkic language, which has been around for 300 years, has a great deal of social studies. The main aim of this paper is that the history of old Turkic inscriptions was formed 4-5th centuries before the European Rune inscription, and that this subject should still be studied in depth. The purpose of this study is to lay the foundation for Turkologists by training future philologists, and to open the way for a more in-depth study of our vision in the future. In recent years, the discovery of many exhibits in the territory inhabited by nomads can serve as an occasion to change the content of the prediction. This paper presents the thought that old Turkic scripts inherent to them. This idea is based on the opinions of famous scientists, based on the symbols of the Old Turkic tribes. This article focuses on scientific research from current scientists. The new data presented during the training of future philologists regarding the genesis of the ancient Turkic script will be analyzed.
Empowerment strategy for people with disabilities through nonformal batik education program
Authors: Mulyono Sungkowo Edy , Putra Widhanarto Ghanis , Sutarto Joko , Malik Abdul , Shofwan Imam
Published: October 2023

Efforts to improve the welfare of people with disabilities are the focus of the state as one of the ways to achieve equitable national welfare. Empowerment strengthens the presence of people with disabilities through climate growth and potential development to grow and develop into strong and independent individuals or groups of people with disabilities. This research aims to develop an empowerment strategy for people with disabilities through nonformal batik education programs. This research used Developmental Research and Utilization Model (DRU Model) with a mixed qualitative and quantitative approach. It is concluded that there are three main strategies for empowering people with disabilities: (1) awareness of people with disabilities and their parents of people by providing direction and motivation so that people with disabilities have the skills to support their future and are no longer dependent on their parents and families; (2) the formation of disability community groups to facilitate interaction among people with disabilities or with society and increase self-confidence; (3) implementation of education and training so that people with disabilities have skills for a livelihood by working in industries or entrepreneur. The value of the variable competency test positively influences the achievement of disability work with a regression coefficient of 0.07. These results indicate that if the competency test scores increase by 1%, the work performance of people with disabilities will increase by 0.07. The implication of this research is the formation of groups of people with disabilities who passed education and training with skills and livelihoods to make batik can carry out the entrepreneur and a model for developing community empowerment strategies for people with disabilities.
Construct validity of the instrument of digital skill literacy
Authors: Harlanu Muhammad , Suryanto Agus , Ramadhan Syahrul , Wuryandini Endang
Published: October 2023

This research is descriptive research that is conducted by quantitative approach to find out the validity and reliability of an instrument. The population in this research is all active college students at the State University of Semarang in nine faculties, taking sample is conducted by probability-sampling that means all population has the same chance to be a research subject. The number of samples in this research is 300 of people. The technique of data analysis on the validity verification in this research used Confirmatory Factor Analysis (CFA) technique. Meanwhile, for the estimation of reliability, the researcher used the formula of Cronbach’s Alpha. The data analysis is supported by JAMOVI program. The result of research shows that a) the instrument of digital skill literacy has fulfilled the criteria of goodness of fit with the result; 1) x2 = 162 dan df = 143; 2) p-value = 0,133; 3) RMSEA 0,021; 4) SRMR = 0,026; 5) and CFI = 0,99; b) the result of CFA shows 20 items that is divided by the indicator such as functional skill beyond, creativity, collaboration, communication, the ability to find select information, critical thinking and evaluation, cultural and social understanding, E-Safety have fulfilled valid criteria with the average score of loading factor is 0.80. c) the reliability of literacy digital skill instrument shows the estimation value which is 0.943 or very reliable.
LINKING MATHEMATICS AND CULTURAL PRACTICES OF THE AGTA TABANGNON IN THE UPLAND COMMUNITIES OF GOA, PHILIPPINES
Authors: Briones Salvador II Villar , Briones Shane Catolico , Palmes Marieta Pelon
Published: October 2023

The main foundation of ethnomathematics is an awareness of the many ways of knowing and doing mathematics that relate to the values, ideas, notions, procedures, and practices in a diversity of contextualized environments. The ethnomathematical practices of the Agta Tabangnon refer to the form of varying mathematical concepts that are embedded in their cultural practices. This paper presents the results of the efforts in documenting the ethnomathematics of the Agta Tabangnon in Sitio Ruras, Barangay Hiwacloy, Goa, Camarines Sur, Philippines. The significant contributions and challenges relative to their ethnomathematical concepts and cultural practices were also discussed. The Agta Tabangnon is a society that manifests stable cultural practices that capture and address every facet of their daily lives. Their ethnomathematics are instances of cultural practices that are passed down from generation to generation and have had a significant impact on society. Their ethnomathematics and cultural practices are the way their cultural group mathematizes their own realities in order to survive earnestly, so learning their practices is one way for us to embrace cultural diversity in our increasingly interconnected world.
Analysis of the needs of teachers of SMAN 3 Sidoardjo in the creation and use of learning media
Authors: Nenohai Jacky Anggara , Rokhim Deni Ainur , Minata Zelen Surya , Agustina Nur Indah , Islamiyah Kafita Krisnatul , Ronggopuro Burhanuddin , Habiddin Habiddin , Peni Ristiwi , Wahyudi Bambang , Wahyudi Asnan
Published: October 2023

This study aims to analyze the needs of teachers of SMAN 3 Sidoardjo in the creation and use of learning media in the teaching and learning process. The research method used is descriptive qualitative by taking data through a Google form-based questionnaire filled out online. The subjects of the study were 51 teachers of SMAN 3 Sidoardjo. The results of the survey based on questionnaire data obtained showed that the learning media used by the teachers of SMAN 3 Sidoardjo in the teaching process was made by as much as 72.5% and 27.5% were not made by themselves, so the media was obtained from Youtube, Google, and colleagues. The media created by several teachers has obstacles, namely mastery of IT (editing and programming languages), a long time in the development process, and its use has not adjusted to the characteristics of students and unites several media and materials in one platform such as  Learning Management System. Therefore, teachers need training and direct assistance in making intensive and simple learning media without using programming languages, flexible time, and accessible anywhere and anytime. Website-based media to accommodate all the material and learning resources taught so that students can easily use the press and improve their understanding of the material and the quality of learning So that teachers and students can adjust the scope and face problems in the learning process by the demands of the times.
Media development board game to increase student motivation in studying regional culture
Authors: Khotimah Khusnul , Wahyuningtyas Neni
Published: October 2023

Media development as an effort to introduce regional culture is considered essential to do. Technological developments make students' motivation to study culture begin to fade and shift with the emergence of Western civilization. This is motivated by the need for more interesting local culture introduction media for students and regional, cultural, and educational content in online or offline media. Therefore, learning media is needed to introduce regional culture. The objectives of this development research are: (1) Producing culture game education media board game products; (2) Testing and knowing the feasibility of culture game education media board game products; and (3) Knowing the effectiveness of culture game education board game media products in increasing learning motivation on material Sub Theme 2: "The Beauty of My Country's Cultural Diversity" for grade IV Elementary School. The development model used is ADDIE. The results of this development research are: (1) Learning media products, board game culture, and game education; and (2) Based on the validation that has been carried out on material experts and learning media experts, it is stated that the culture game education board game is suitable for use in the learning process and can be implemented for students with a percentage of the validity test of material experts, namely 89% and a percentage of the validity test of learning media experts, namely 98%. The results of the practicality test using the culture game education board game by the teacher obtained a score of 91%, while the trial results related to the percentage of students' motivation to learn culture through this media was 86%. The conclusion is based on the development done; the culture game education board game is declared appropriate when used as a medium to introduce regional culture.
Virtual reality video project design to improve vocational teachers' skills in implementing Kurikulum Merdeka
Authors: Endrayanto Yana , Sukmayadi Yudi , Masunah Juju
Published: October 2023

This project aims to improve the skills of vocational teachers in implementing the Merdeka Curriculum, with the design of the Merdeka Curriculum virtual reality video project to encourage the use of a learner-centered approach and prioritize skills-based learning relevant to the world of work. VR video content is designed to improve vocational teachers' understanding and skills in implementing the Merdeka Kurikulum. The purpose of this research is to facilitate teachers to have pedagogical skills in preparing teaching materials to evaluate learning. The method in this research is Action research with the VR video content development process involving determining clear learning objectives, designing a VR curriculum, preparing VR materials and content, and making VR videos using relevant technology and software. Furthermore, VR video content is implemented in vocational teacher learning by providing access to VR devices and clear usage guidelines. Evaluation is conducted to measure the effectiveness of VR videos in achieving learning objectives and obtain feedback from vocational teachers. The results of this project show that using VR videos in vocational teachers' learning can improve their engagement, understanding, and skills in the context of the Merdeka Curriculum. Vocational teachers experience a more interactive and immersive learning experience through a realistic virtual environment. Students also benefit from using VR videos, with an increased understanding of vocational concepts and their readiness for the world of work. The project also faced some challenges, such as the accessibility of VR devices and technical constraints. In discussing the project results, it is recommended to collaborate with related parties and share experiences with the education community so that the use of VR videos in vocational learning can expand and continue to grow.
Liver structure and fibrosis markers in modeling alcohol-induced liver injury and correction of detected disorders
Authors: Didenko V.I. , Klenina I.A. , Hrabovska O.I. , Gaidar Yu.A. , Halinskyi O.O. , Karachynova V.A. , Mylostуva D.F.
Published: October 2023

Background. Chronic alcohol use leads to alcoholic liver fibrosis. Today, a sufficient number of scientific studies are focused on the pathometabolic mechanisms of liver fibrosis development and formation in animal models. The purpose of our study was to investigate structural changes and liver stiffness, biochemical markers of fibrosis in rats with chronic alcoholic liver injury (CALI) modeling and to evaluate the changes of these parame­ters with different types of treatment. Materials and methods. Eighty-nine rats were divided into experimental groups depending on the duration of alcohol exposure (4 and 12 weeks) and the corresponding type of correction (metadoxine and prebiotic). Results. When modeling CALI at week 4, morphological studies revealed moderate large-droplet fatty hepatosis and mild fibrosis in the central venule of the liver lobes. After 12 weeks of forced alcoholization, with more pronounced general intoxication, hepatocytes have dystrophic changes such as appearance of single or grouped dystrophic cells in the parenchyma. A combination of protein and fatty dystrophy was more common. Elastography allowed to detect structural changes in the liver at the early stages of fibrosis formation when modeling CALI for 12 weeks. There were also changes in the levels of biochemical parameters: free and protein-bound hydroxyproline, glycosaminoglycans. According to the results of elastography, liver stiffness in rats increased maximally after prebiotic correction in all approaches compared to the controls. After correction of CALI, both early- and long-term, fibrosis markers normalized in rat liver homogenate after administration of metadoxine and prebiotic. After prebiotic correction at week 12 of alcoholization, we observed a 12% decrease in liver parenchymal stiffness in the CALI modeling group and a 19% decrease (p < 0.05) in the placebo group. After correction with metadoxine, there was a 1.5-fold increase in free hydroxyproline levels in rat liver homogenate at week 12 and a 1.2-fold increase in glycosaminoglycans (p < 0.05) at week 4 compared to the CALI modeling group. Conclusions. Long-term alcoholization of animals led to the development of dystrophic changes in hepatocytes, protein and fatty degeneration, and an increase in the number of capillaries. Against this background, liver stiffness and biochemical parameters changed. After correction with metadoxine and prebiotic, changes in the liver stiffness and fibrosis markers were observed at week 12 of CALI modeling.
The value of osteopontin in predicting fibrosis in patients with chronic viral hepatitis C
Authors: Sheiko A.G. , Yurko K.V.
Published: October 2023

Background. Diagnosis of an asymptomatic course of chronic viral hepatitis C (HCV) and the existing development of the fibrotic process by determining the marker capabilities of biochemical blood parameters (primarily osteopontin — OP) is an urgent issue in modern medicine. Purpose: to evaluate the prognostic value of biochemical blood markers for diagnosing an asymptoma­tic course of HCV and the existing fibrotic process. Materials and me­thods. Seventy-eight people were examined: 47 from the main group — 19 (40.4 %) women and 28 (59.6 %) men with chronic HCV, and 31 controls — 17 (54.8 %) women and 14 (45.2 %) men without chronic HCV. The median, as well as 25.0% and 75.0% quartiles and relative values were calculated for quantitative and qualitative measures, respectively. Predictors were determined using logistic regression analysis. Results. The data obtained by a univariate analysis indicate a significantly increased risk of develo­ping liver fibrosis on the background of chronic HCV, with alanine aminotransferase (ALT) levels increased by 1.037 times, aspartate aminotransferase (AST) by 1.051 times, gamma-glutamyl transferase (GGT) by 1.017 times; thymol turbidity test by 1.424 times; total protein by 1.162 times and OP by 3.002 times. With increased levels of triglycerides and very low-density lipoproteins, a significant decrease in these risks was found, by 74.7 and 94.7 %, respectively. A multivariate analysis found significantly increased risks of deve­loping liver fibrosis on the background of chronic HCV, with higher levels of AST, total protein, and OP (by 1.028, 1.195 and 2.510 times, respectively). Conclusions. With a significant liver damage by a fibrotic process (stage 3–4), as compared to stage 0–2, there is a probable predominance of biochemical liver markers in the blood of patients with HCV: ALT, AST, GGT, total protein and OP. AST, total protein, and OP were identified as reliable predictors of liver fibrosis. The developed mathematical model has high sensitivity and specificity: 87.5 and 83.9 %, respectively.
Utilization of Steepest Ascent and Box-Behnken Design for Determination of Gadolinium in Acetonitrile by Differential Pulse Voltammetry
Authors: Wyantuti Santhy , Pratomo Uji , Hartati Yeni Wahyuni , Shafira Amelia , Hardianto Ari , Bahti Husein Hernandi
Published: October 2023

Gadolinium (Gd) is an important material for advanced technology; hence, the development of a sensitive and efficient alternative for the Gd-detection method to reduce the dependency on complicated and expensive methods has been massively investigated. Furthermore, the combination of differential pulse voltammetry (DPV) and the experimental design to detect Gd provides a simple, effective, and efficient method. In this study, the Steepest Ascent and Box-Behnken designs were chosen to determine the maximum voltammetry responses. The optimum conditions used for this study showed an amplitude modulation of 0.0884 V, potential deposition of 1.4382 V, and deposition time was 60.3615 s with the obtained recovery value, accuracy, and precision values being 98.37, 95.91, and 5.12% in relative standard deviation (RSD), respectively. Meanwhile, the detection and quantization limit values are 3.46 and 11.53 mg/L, respectively. Under optimum conditions, the presence of Gd in acetonitrile is determined in a mixture with Eu and Sm. Based on the results, the DPV method is capable of determining the presence of Gd in acetonitrile.