bluuebunny/crossref_metadata_2025 huggingface dataset:
Чинники впливу на впізнаваність бренду у кросмедійній продукції
Authors: Іваненко Дарина Олександрівна , Розум Тетяна Володимирівна
Published: March 2023

В роботі наведено результати дослідження сучасного стану технології зі створення кросмедійної рекламної продукції та чинників, що впливають на впізнаваність бренду. Виконано патентний пошук за чотирма тематичними напрямами та визначено тенденції розвитку кросмедійних технологій у галузі креативної реклами. Проаналізовано наповнення та цільову аудиторію кросмедійної рекламної продукції.
На основі проведеного аналізу та патентного пошуку визначено тенденції розвитку технологій, програмного і апаратного забезпечення та дизайну кросмедійних рекламних продуктів. За результатами аналізу можна сказати, що кросмедійна рекламна продукція активно розвивається і впізнаваність бренду для цієї продукції є актуальною та перспективною тематикою.
Патентний аналіз за останні десять років виявив сталий розвиток сучасних технологій, методів та апаратно-програмних засобів для створення кросмедійної рекламної продукції. У динаміці патентування стрімке зростання відзначено у 2018 р., що підтверджується великою кількістю виданих патентів в США, Японії, Польщі, Україні та Німеччині. Найбільш поширеними напрямами патентування є створення кросмедійної продукції, креативної реклами, загалом рекламної продукції та програних продуктів для розробки рекламної продукції.
В роботі представлено авторську класифікацію рекламної продукції за методами розміщеннями і каналами розповсюдження, а також кросмедійних рекламних продуктів за цільовою аудиторією, циклічністю, часом сприйняття інформації та каналами розповсюдження. Проаналізовано процес створення дизайну для кросмедійної рекламної продукції та розроблено причинно-наслідкову діаграму, що систематизує та виокремлює фактори, які впливають на ефективність кросмедійної рекламної продукції. Серед факторів відібрано основні, що впливають на ефективність впізнаваності продукції та при створенні продукту.
Monitorización del consumo eléctrico a través de flujos de datos para la gestión inteligente y sostenible de edificios públicos = Monitoring electricity consumption through data streams for smart and sustainable management of public buildings
Authors: Montalbán-Pozas Beatriz , Lucas-Bonilla Marta , García-Iglesias Beatriz , Barroso-Ramírez Sergio , Bustos-García-de-Castro Pablo , Serrano-Candela Francisco
Published: March 2023

La situación actual de escasez de recursos energéticos, unido a la ineficiencia en el uso de los edificios, y al avance de la tecnología sugiere la implantación de sistemas inteligentes para un uso más sostenible. En este texto se expone el desarrollo de un sistema de información heterogéneo que permite la monitorización de las infraestructuras edificatorias, y la integración de datos en una plataforma digital de visualización, dentro de una arquitectura escalable y de fuentes abiertas. Se ha implementado en el caso de estudio del municipio del Casar de Cáceres, y en el ámbito del consumo eléctrico de los edificios públicos; este municipio cuenta con unos 4500 habitantes y 39 contratos de contadores públicos que se agrupan según cada edificio y su tipología de uso (sanitario, educativo, culturales, asistenciales, otros, y alumbrado público). El uso de estos indicadores facilitará el establecimiento de políticas de evaluación de los edificios. Para finalizar, estos flujos de datos facilitarán la gestión municipal y mejorará la calidad de los servicios ofrecidos, permitiendo además mejorar su eficiencia y el ahorro de recursos, tanto naturales como humanos y económicos.AbstractThe current situation of scarcity of energy resources, together with the inefficient use of buildings and the advance of technology, suggests the implementation of intelligent systems for a more sustainable use. This text presents the development of a heterogeneous information system that allows the monitoring of building infrastructures and the integration of data in a digital visualisation platform, within a scalable and open-source architecture. It has been implemented in the case study of the municipality of Casar de Cáceres, and in the field of electricity consumption of public buildings; this municipality has about 4500 inhabitants and 39 public meter contracts that are grouped according to each building and its type of use (health, education, cultural, welfare, other, and public lighting). The use of these indicators will facilitate the establishment of building evaluation policies. Finally, these data flows will facilitate municipal management and improve the quality of the services offered, as well as improving their efficiency and saving resources, both natural, human and economic.
Estudio y análisis comparativo del consumo real de una vivienda passivhaus y del rendimiento de su instalación de aerotermia = Study and comparative analysis of the real consumption of a passivhaus house and the aerothermal installation performance
Authors: De-la-Cruz-Pérez Lucio
Published: March 2023

En el artículo se analiza desde el punto de vista del consumo de energía como ha sido el comportamiento real de una vivienda de tipología residencial colectiva certificada Passivhaus y construida en el año 2019. La citada vivienda, que está ubicada en el municipio de Zaragoza en zona climática D3, ocupa la primera planta de un edificio de 3 alturas y tiene todos los sistemas de producción térmica y resto de servicios alimentados con energía eléctrica. El estándar Passivhaus es un certificado de edificios de muy alta eficiencia energética que tiene entre sus características que las viviendas tengan una demanda de energía para calefacción y para refrigeración inferior a 15 kWh/m2 y año para ambos casos, con una carga de calefacción y refrigeración menor o igual a 10 W/m2. Finalmente se realiza un estudio comparativo real del rendimiento real y del COP de la instalación de producción térmica de la aerotermia para cada uno de los tres servicios (ACS, calefacción y refrigeración), en cada uno de los meses del año, bajo diversas hipótesis operativas y de temperaturas de consigna, obteniendo resultados muy interesantes desde el punto de vista de determinar cuál es el servicio que más energía consume y de establecer unos parámetros de funcionamiento de estas instalaciones para un mejor aprovechamiento térmico de la vivienda. Se realiza también un comparativo con una vivienda construida con criterios bioclimáticos en el año 2009.AbstractThe article analyses from the point of view of energy consumption the real behaviour of a Passivhaus-certified collective residential dwelling built in 2019. The house, which is located in the municipality of Zaragoza in climate zone D3, occupies the first floor of a 3-storey building and has all the thermal production systems and other services powered by electricity. The Passivhaus standard is a certificate for buildings with very high energy efficiency, whose characteristics include that the dwellings have an energy demand for heating and cooling of less than 15 kWh/m2 and year for both cases, with a heating and cooling load of less than or equal to 10 W/m2. Finally, a real comparative study is made of the real performance and COP of the aerothermal thermal production installation for each of the three services (DHW, heating and cooling), in each of the months of the year, under different operating hypotheses and setpoint temperatures, obtaining very interesting results from the point of view of determining which service consumes the most energy and establishing the operating parameters of these installations for a better thermal use of the dwelling. A comparison is also made with a house built with bioclimatic criteria in 2009
Valoración económica, ambiental y desempeño estructural de diferentes hormigones = Economic, environmental, and structural performance assessment of different concretes
Authors: Roca-Francín Ana , Ferreiro-Cabello Javier , Fraile-García Esteban
Published: March 2023

La dirección de proyectos de construcción, respetando el entorno y los parámetros ambientales es un tema ya abordado con anterioridad en multitud de trabajos científicos. Éste trabajo tiene como objetivo comparar y analizar los distintos parámetros ambientales derivados del análisis del ciclo de vida, concretamente en la etapa de producto, fases A1, A2 y A3 y los costes económicos incurridos en una estructura modelo, utilizando diferentes hormigones armados HA25, HA30, HA35, HA40, HA45 y HA50. Demostrando la utilidad que tiene para los directores de proyectos en el proceso de toma de decisiones, disponer de un análisis comparativo de parámetros medioambientales frente al coste económico. Éste estudio se ha realizado sobre una estructura en concreto, por lo que los resultados obtenidos son propios del edificio analizado. Sería muy interesante realizar éste estudio sobre una muestra de estructuras más amplia. Se podría, de ese modo, analizar cómo influyen en los parámetros ambientales otros factores como la geometría, la utilización de diferentes soluciones estructurales o diferentes datos de cálculo, como las cargas de viento o nieve.AbstractThe management of construction projects, respecting the environment and environmental parameters, is a subject that has already been addressed in many scientific works. The aim of this work is to compare and analyse the different environmental parameters derived from the life cycle analysis, specifically in the product stage, phases A1, A2 and A3 and the economic costs incurred in a model structure, using different reinforced concretes HA25, HA30, HA35, HA40, HA45 and HA50, demonstrating how useful it is for project managers in the decision-making process to have a comparative analysis of environmental parameters versus economic cost. This study has been carried out on a specific structure, so the results obtained are specific to the building analysed. It would be very interesting to carry out this study on a larger sample of structures. In this way, it would be possible to analyse how other factors such as geometry, the use of different structural solutions or different calculation data, such as wind or snow loads, influence the environmental parameters.
Willingness To Pay for HPV Vaccine Among Women Living With HIV in Nigeria
Authors: Akinsolu Folahanmi , Abodunrin Olunike , Adewole Ifeoluwa , Olagunju Mobolaji , Gambari Aisha O , Raji Dolapo , Idigbe Ifeoma , Njuguna Diana W , Salako Abideen , Ezechi Oliver
Published: March 2023

Background: Human papillomavirus (HPV) is responsible for most cervical cancer cases globally, with women living with HIV at higher risk of persistent HPV infection and HPV-associated disease. The HPV vaccine is a promising solution to reducing cervical cancer rates, but its uptake among women living with HIV in Nigeria is unknown.
Methods: A facility-based, cross-sectional survey was conducted with 1,371 women living with HIV to assess their knowledge of HPV, cervical cancer, and the HPV vaccine, as well as their willingness to pay for the vaccine at the HIV treatment clinic, Nigerian Institute of Medical Research, Lagos. Willingness to pay for the HPV vaccine was also assessed. Multivariable logistic regression models were developed to identify factors associated with willingness to pay for the HPV vaccine.
Results: The study found that 79.1% of participants had not heard of the vaccine, and only 29.0% knew of its efficacy in preventing cervical cancer. Moreover, 68.3% of participants were unwilling to pay for the vaccine, and the average amount they were willing to pay was low. Knowledge of HPV, the HPV vaccine, cervical cancer, and income were factors associated with willingness to pay for the vaccine. Health workers were the primary source of information.
Conclusion: The study found that 79.1% of participants had not heard of the vaccine, and only 29.0% knew of its efficacy in preventing cervical cancer. Moreover, 68.3% of participants were unwilling to pay for the vaccine, and the average amount they were willing to pay was low. Knowledge of HPV, the HPV vaccine, cervical cancer, and income were factors associated with willingness to pay for the vaccine. Health workers were the primary source of information.
Out-of-Pocket Costs Related to Chagas Disease: The Experience in Endemic Municipalities in Colombia
Authors: Herazo Rafael , Rey Adriana , Galvao Diogo , Medina Camargo Manuel , Cobos Pinzón Nini Johana , Rodriguez Sanchez Alba Cecilia , Marchiol Andrea , Pinazo María Jesus
Published: March 2023

Background

Out-of-pocket costs are key expenses that many individuals incur in order to receive health services. They have been identified as a key access barrier for vulnerable populations, in particular for populations affected by neglected diseases with a chronic progression, such as Chagas disease. It is important to understand the costs of accessing healthcare services that are borne by patients with T. cruzi infection.

Methodology

We prepared a structured survey for patients with T. cruzi infection/Chagas disease who were all treated by the healthcare system in endemic municipalities in Colombia. The results were analyzed according to three categories: 1. the socioeconomic profiling of the patients; 2. the costs of and time spent on transportation; and 3. the opportunity costs (money that was not earned) related to treatment at the local primary care hospital or at the high-complexity reference hospital.

Main findings

Ninety-one patients answered the survey voluntarily. The data revealed that, when treated at the specialized reference hospital, patients spent 5.5 times more on food and accommodation, transportation costs were five times higher, and the loss of earnings was three times higher than when they were treated at the local primary care hospital. Moreover, the amount of time spent on transportation was 4 times higher at the reference hospital.

Conclusions

Providing comprehensive healthcare services for Chagas management at local primary healthcare hospitals would allow the most vulnerable patients to save on expenses related to medical and non-medical costs (out-of-pocket costs), in turn leading to higher adhesion to treatment thus benefiting the health system as a whole.

These findings are in alignment with the WHO’s World Health Assembly 2010 Resolution on the importance of treating Chagas at local primary care hospitals, thereby saving patients time and money, allowing for timely care, and promoting access to healthcare.
Stachydrine and Synephrine, a Pair of Bioactive Equilibrists in Four Chinese Herbs from Citrus Genus
Authors: Sun Yifei , Xia Xuexue , Yuan Ganjun , Zhang Tongke , Deng Beibei , Feng Xinyu , Wang Qixuan
Published: March 2023

Four Chinese herbs Zhishi, Zhiqiao, Qingpi and Chenpi from Citrus genus were widely used for treating various cardiovascular and gastrointestinal diseases. Although many pharmacological functions of these herb decoctions can be clarified from the bioactivities of identified ingredients, some of them remain confusing. To clarify the reasons of those confusing functions, depending on the extended structure-activity relationships of cholinergic and anti-cholinergic agents, here a simple method for quickly discovering possible choline analogs was established using a specific TLC method, and then stachydrine and choline were first identified from these Citrus herb decoctions based on their NMR and HRMS data. After this, two TLCS methods were first established respectively for the quantitatively analyses of stachydrine and choline, and the contents of both two ingredients and synephrine in 39 samples were determined using the valid TLCS and HPLC methods, respectively. The results showed the contents of stachydrine were 2.4 times to those of synephrine in Zhiqiao while about 1/3 to 2/3 in Zhishi, Qingpi and Chenpi. Simultaneously, the contents of stachydrine, choline and synephrine in these herbs present similar changing trends along with the delay of harvest time. However, the contents of synephrine decrease most rapidly, while those of stachydrine decrease most slowly. Based on these above, comparing with the pharmacological activities and pharmacokinetics reported of stachydrine and synephrine, it indicated that stachydrine and synephrine can be considered as a pair of bioactive equilibrists, especially in the cardio-cerebrovascular protection from these citrus herbs. Simultaneously, it confirmed that stachydrine should play an important role in the pharmacological functions, especially in dual-directionally regulating the uterus and various beneficial effects on cardio-cerebrovascular system, kidney and liver, of these citrus herbs.
Mass Mortality of Asari Clams (Ruditapes philippinarum) Triggered by Wind-Induced Upwelling of Hypoxic Water Masses: Implication of Hydrogen Sulfide Release Associated With Biogenic Organic Loads
Authors: Sone Ryota , Miyawaki Dai , Ishida Toshiro , Kamohara Satroru , Waku Mitsuyasu , Inoue Tetsunori , Suzuki Teruaki
Published: March 2023

To investigate the mass mortality of asari clams triggered by upwelling-driven hypoxia, we conducted biological and oceanographic observations of the Rokujo tidal flat in Mikawa Bay, central Japan. In addition, a simple laboratory experiment was conducted using sediments on a tidal flat containing macrobenthos to examine the possibility of hydrogen sulfide formation in tidal flats. The results of field observations showed that the number and biomass of asari clams decreased from September to October in the tidal flat when hypoxia was intermittent. In particular, hypoxia persisted for approximately one week from September 21, which was associated with the calm weather and stagnation of tidal currents owing to the neap tide. The hydrogen sulfide concentration in the water directly above the sediment exceeded 30 mg L-1 after 3 days of incubation. Our results suggest that the mass mortality of asari clams may be caused by the high concentration of hydrogen sulfide produced by sulfate reduction, which is attributed to the chain of biological die-off caused by the upwelling of hypoxic water mass accompanied by meteorological events, and calm conditions such as the neap tide period.
LC, POTS, and ME/CFS: Lifting the Fog
Authors: Chambers Patrick
Published: March 2023

These three syndromes - long covid (LC), postural orthostatic tachycardia syndrome (POTS), and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) - have many symptoms in common. The common denominator remains elusive. The blood brain barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic links. There are several areas within the brain that have no BBB. These are known as circumventricular organs (CVOs) and their location relative to CNS nuclei that direct autonomic and neuroendocrine functions is provocative in the quest for pathogenesis. In addition the majority afflicted with LC and ME/CFS appear to be those with two MTHFR polymorphisms, present in over 50% of Americans. These polymorphisms elevate homocysteine. When homocysteine is combined with CVOs, the fog of POTS and its paradox are lifted. POTS may represent the intersection of LC and ME/CFS in those with the MTHFR gene (hypermethylation or 677TT). The gut microbiomes of LC and ME/CFS, deficient in butyrates, GABA, and diversity, are then linked with MTHFR genotype 677TT. Reactivation of neurotropic EBV and VZV, due to loss of surveillance by CD4+/CD8+ T cells, is seen as secondary. The oxidative stress generated by homocysteine, loss of glutathione, low fiber diet, and persistent chronic inflammation exhaust available mitochondria and, assisted by BKN and estrogen, exacerbate all the elements of these post viral fatigue syndromes.
Modern Paediatric Emergency Department: Potential Improvements in Light of New Evidence
Authors: Kula Roman , Popela Stanislav , Klučka Jozef , Charwátová Daniela , Djakow Jana , Štourač Petr
Published: March 2023

The increasing attendance of paediatric emergency departments becomes a serious health issue. To reduce an elevated burden of medical errors, inevitably caused by high level of stress exerted on emergency physicians, we propose potential areas for improvement in regular paediatric emergency departments. In effort to guarantee demanded quality of care to all incoming patients, the workflow in paediatric emergency departments should be sufficiently optimized. The key component remains implementing one of the validated paediatric triage systems upon patient's arrival at emergency department and fast-tracking patients with low level of risk according to the triage system. To ensure the patient's safety, emergency physicians should follow issued guidelines. Cognitive aids, such as well-designed checklists, posters or flow charts, generally improve physicians' adherence to guidelines and should be therefore available in every paediatric emergency department. To sharpen diagnostic accuracy, the use of ultrasound in paediatric emergency department, according to ultrasound protocols, should be targeted to answer specific clinical questions. Combining all mentioned improvements might reduce number of errors linked with overcrowding. The review serves not only as a blueprint for modernizing paediatric emergency departments, but also as a bin of useful literature which can be suitable in the paediatric emergency field.
Navigating the Hidden Politics of Water Resource Bureaucracies in Indonesia: Mapping Issue-Elements and Alliances
Authors: Sahide Muhammad Alif K. , Fisher Micah R. , Hasfi Nurul , Mas’ud Emban Ibnurusyd , Yunus Ahsan , Faturachmat Fatwa , Larekeng Siti Halimah , Maryudi Ahmad
Published: March 2023

Water resource politics are often overlooked for jurisdictional perspectives, or difficult to comprehend for the politics unfolding behind the scenes. Using Indonesia as a case study, we synthesized all water-related bureaucracies to generate a list of “Water resource Issue-Elements,” which served as a framework for translating actor-centered power dynamics. The data is based on policies reviewed from 2014 to 2017, coinciding with the beginning of a new presidential administration with heightened interests in water resource management. The study found that while the central coordinating and planning bureaucracies wield the strongest network power, two sectoral bureaucracies hold tremendous influence in guiding water resource management, which unfold under conditions of highly fragmented politics. On the one hand, the Ministry of Environment and Forestry influences water resources through its land management mandate and seeks to enlarge its bureaucratic power beyond state forest boundaries through the concept of watersheds. On the other hand, The Ministry of Public Works and Housing maintains its traditional mandate for managing river basins, wielding large budgets and networks to control information and determine project-related disbursements. As these two bureaucracies shape alliances administering water resources, their delegating responsibilities also refract to regional bureaucracies, shaping a new set of subnational contestations.
RESULTS OF MODELING OF COMPONENTS AND WORKING PROCESSES OF A HYBRID CAR WITH AN ASYNCHRONOUS MOTOR
Authors: Sergienko Nikolay , Pavlova Nataliya , Sergienko Anton , Lyubarsky Boris , Borysenko Anatolyi , Kalinin Pavel , Gubskyi Sergii , Dreval Oleksandr
Published: March 2023

The work presents simulation models of the control and monitoring system, the study of the dynamics of the parameters of the elements of a hybrid car using simulation modeling in Matlab / Simulink environment is performed. A series-parallel drive of driving wheels is considered. The electric drive is carried out from an asynchronous electric motor. The model includes energy consumption regulation and control subsystems, calculation and state control of the battery, internal combustion engine, electric drive, mechanical model of the car, simulator of driver's influence on the fuel pedal, driving mode control system. The changes in the operating parameters of the hybrid vehicle components and the vehicle itself on the given driving modes are presented. The results obtained correspond to the real values for the selected class of cars.
INCREASING THE RESOURCE OF VEHICLE PARTS BY COMPOSITE MATERIALS DURING THEIR RESTORATION REPAIR
Authors: Luzan Sergii , Bantkovskiy Vyacheslav , Klymenko Ilya , Bilous Leonid
Published: March 2023

To restore machine parts used quite a large range of materials in the form of wire, powders, flexible cords, etc. However, it is not always possible to provide the required resource for the restoration of parts working in abrasive and corrosive environments. One of the modern directions of increasing the wear resistance and other properties of reducing coatings is the use of composite materials. This paper presents the results of research on the development of a composite modifying material to control the properties of reducing coatings based on commercially available powder material PG- 10N-01. It is shown that the developed composite material obtained using the SHS process from a powder mixture of Ti+C+SiO2+Al2O3+Fe2O3+Al+PT-NA-01 provides a higher (1.65 times) abrasive resistance of the deposited alloy coating PG-10N-01 when modifying its composite material in the amount of 20%.
MONITORING PROPOSITION OF THE EUROPEAN BADGER (MELES MELES)
Authors:   Faculty of Animal Breeding, Bioengineering and Conservation, Warsaw University of Life Sciences – SGGW, Warszawa, Poland, BORUCKA Agata
Published: March 2023

The paper presents proposed methods for monitoring the European badger in Poland. In addition to the characteristics of the species, habitat requirements, threats and conservation perspectives are discussed. Based on literature data, indicators were developed to provide reliable information on population size and habitat condition. Furthermore, an example of a completed observation card and the resulting assessment is provided. Data collected in the recommended manner may help to learn about the current situation of badgers in Poland and thus contribute to the implementation of appropriate measures for their protection.
Mužský odev 18. storočia v zrkadle súdnych písomností z Liptovskej stolice
Authors: Nemec Miroslav
Published: March 2023

The clothing of criminals in the 18th century did not differ significantly from the clothing of the people around them, which is hardly surprising, as they came from their ranks. However, we can see in their clothing a reflection of their professional or social status. For example, it is evident from the clothing of most robbers that they came from a shepherd’s environment. In their clothing, we find components that have been explicitly designated as shepherd’s or were often found on shepherd’s clothing. Various forms of individual decoration are found on trousers and headgear, such as cloth ribbons and beads in particular, and also seashells. As for other categories of criminal, identifying a pattern for such a small number of cases is complicated. However, in general, their clothing contained mostly elements typical of their status or profession. Still, it is clear that even the clothes of the lower social groups were not uniform.
Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena
Authors: Nanda Aditya , Johnson Graham , Mu Yu , Ahrens Misha , Chang Catie , Englot Dario , Breakspear Michael , Rubinov Mikail
Published: March 2023

Much of systems neuroscience posits the functional importance of brain activity patterns
that lack natural scales of sizes, durations, or frequencies. The field has developed
prominent, and sometimes competing, explanations for the nature of this scale-free activity.
Here, we reconcile these explanations across species and modalities. First, we
link estimates of excitation-inhibition (E-I) balance with time-resolved correlation of distributed
brain activity. Second, we develop an unbiased method for sampling timeseries
constrained by this time-resolved correlation. Third, we use this method to show that
estimates of E-I balance account for diverse scale-free phenomena without need to attribute
additional function or importance to these phenomena. Collectively, our results
simplify existing explanations of scale-free brain activity, and provide stringent tests on
future theories that seek to transcend these explanations.
Recurring Suboptimal Choices Result in Superior Decision Making
Authors: Mondal Supratik , Lenda Dominik , Traczyk Jakub
Published: March 2023

A vast body of research has indicated that individuals with higher statistical numeracy, in comparison to individuals with lower statistical numeracy, make superior decisions by employing more deliberative processes leading to selecting options with the highest expected value (EV). However, it is not feasible to deliberate every time we make a choice due to cognitive and environmental constraints. In one simulation study and three well-powered, fully-incentivized empirical studies using the decision-from-experience task, we identified conditions where recurring suboptimal choices were more rewarding than a normatively superior strategy. That is, even if individual choices in isolation are considered suboptimal in light of the EV maximization principle, individuals with higher numeracy can adapt their decision strategy in accordance with changes in the task structure, and make faster suboptimal (or random in terms of EV maximization) decisions that result in overall superior performance (e.g., earning more money). We found that individuals who maximized EV without time constraints accumulated higher total gain. However, the trend reversed in the following two studies. Participants who made more suboptimal choices, under time constraints, earned more money than those who spent more time maximizing EV. Importantly, we found that more numerate individuals made significant adjustments to their meta-cognitive decision processes and made more quick suboptimal choices resulting in better overall earnings than less numerate individuals. Finally, our results also indicate that more numerate individuals are better at identifying the changes in the task structure and are more rational in their use of cognitive and environmental resources.
Polycystic Ovarian Syndrome (PCOS) and its association with VDR gene variants Cdx2 (rs11568820) and ApaI (rs7975232): Systematic Review, Meta-analysis and In silico analysis
Authors: Gupta Komal , Thakur Richa , Sharma Priya , Kamra Pooja , Khetarpal Preeti
Published: March 2023

Objective: Polycystic ovary syndrome (PCOS) is a multifactorial and polygenic disorder of women in the reproductive-age group. Among various reasons, Vitamin D level and Vitamin D receptor (VDR) polymorphism have been investigated as one of the predisposing causes. The study aims to investigate the association between VDR polymorphism and PCOS susceptibility.
Methodology: Online databases (PubMed, Central Cochrane Library, Science Direct and Google Scholar) were searched up to 30th March, 2022. With suitable syntax. Odds Ratios (OR) with 95% Confidence Interval (CI) and Chi-square (χ2) tests were applied under different genetic models to find the association between Cdx2 G>A (rs11568820) and VDR ApaI C>A(rs7975232) polymorphisms with PCOS risk. All the statistical calculations were performed using Review Manager 5.3 software (Cochrane Collaboration, Oxford, UK). To understand molecular effect of variants in the untranslated region, in silico analysis was performed using Regulome DB, FATHMM-MKL and Haploreg v4.1 web tools.
Results: Total fifteen case-control studies were identified with 2114 PCOS patients and 1552 control subjects.
VDR variant Cdx2 (rs11568820) was found to be significantantly associated (OR= 0.40, 95% CI= 0.22-0.72, p= 0.002) after the odd one out analysis of one major study. VDR variant ApaI is significantly associated with PCOS under all four genetic models: Dominant Model (AA + AC vs CC): OR= 0.75, 95%CI= 0.62-0.91,p= 0.003; Recessive model (AA vs. AA+AC): OR= 0.78, 95%CI= 0.63-0.98, p= 0.03; Additive model(AAvsAA+CC):OR=0.70,95%CI=0.57-0.87,p=0.001 and Allele model (A vs C): OR= 0.83, 95%CI= 0.74-0.91, p=0.0002 indicating ‘A’ allele as risk factor. Subgroup analysis revealed significant association among Asian population. However, In silico analysis of the intronic variants have yielded contradictory results.
Conclusion: The study revealed VDR Cdx2 and ApaI polymorphism as a significant risk factor for PCOS.
Potent anthelmintic activity of a colloidal nano-silver formulation (Silversol®) against the model worm Caenorhabditis elegans
Authors: Gajera Gemini , Godse Chhaya , DeSouza Anselm , Mehta Dilip , Kothari Vijay
Published: March 2023

Objective
In the background of a very small number of effective anthelmintics available today with a narrow activity spectrum, and a rise in resistance against them among parasitic helminths, there is an urgent need for discovery of novel broad-spectrum anthelmintics displaying no or minimal toxicity towards the host. Silver being used since centuries for therapeutic purposes and considered safe for human consumption, we investigated anthelmintic activity of a colloidal nanosilver formulation Silversol®. Anthelmintic efficacy of the test formulation was assayed employing the nematode Caenorhabditis elegans as a model worm through a live-dead count.
Results
Silversol® exerted anthelmintic action superior to one of the positive controls (Benzimidazole), and almost at par to another positive control (Ivermectin). At concentrations ≥2 ppm, it could kill all the worms present in the experimental well. Lower concentrations of silver were found to have a cuticle-damaging action on worms. Further investigation is warranted to assess whether Silversol® can exert similar potent activity against different species of parasitic helminths, and elucidate the underlying molecular mechanisms of action.
Joint PAPR and Non-linear Distortion Mitigation in OQAM-FBMC based Visible Light Communication System
Authors: Kumar Sanjeev , Singh Preeti
Published: March 2023

Light emitting diode (LED) non-linearities bounds the output of visible light communication (VLC) system. In this work, non-linear distortion mitigation in VLC system is presented. Distortion due to LED’s front-end components and high peak to average power ratio (PAPR) effects are discussed. Both pre-distortion and post-distortion techniques are analyzed for the minimization of non-linear distortion of intensity modulation/direct detection (IM/DD) based channel. The modulation technique used is offset quadrature amplitude modulation (OQAM) - filter bank multi-carrier (FBMC). A joint PAPR reduction and non-linear distortion mitigation technique for VLC is proposed. The proposed technique consists of hybrid processing algorithm partial transmit sequence (H-PTS) technique for PAPR reduction and kernel minimum symbol error rate (KMSER) based post-distortion method for reduction of non-linear distortion. The results have shown that proposed technique shows 2 dB improvement in PAPR and 4 dB improvement in non-linear distortion of VLC system.
Optimized model architectures for deep learning on genomic data
Authors: Münch Philipp , Gündüz Hüseyin Anil , Mreches René , Moosbauer Julia , Robertson Gary , To Xiao-Yin , Franzosa Eric , Huttenhower Curtis , Rezaei Mina , McHardy Alice , Bischl Bernd , Binder Martin
Published: March 2023

In computational biology, there is a lack of agreement on the optimal design of deep learning architectures, such as types and number of layers, often resulting in non-optimal design choices. We introduce GenomeNet-Architect, an architectural design framework that researchers can use to optimize deep learning models for genome sequence data. Relative to the best-performing baseline, GenomeNet-Architect reduces the read-level misclassification by 19%, with 32% faster inference and 83% fewer parameters.
Seasonality of Cholera in Kolkata and the Influence of Climate
Authors: Shackleton Debbie , Economou Theo , Memon Fayyaz , Chen Albert , Dutta Shanta , Kanungo Suman
Published: March 2023

Background
Cholera in Kolkata remains endemic and the Indian city is burdened with a high number of annual cases. Climate change is widely considered to exacerbate cholera, however the precise relationship between climate and cholera is highly heterogeneous in space and considerable variation can be observed even within the Indian subcontinent. To date, relatively few studies have been conducted regarding the influence of climate on cholera in Kolkata.
Methods
We considered 21 years of confirmed cholera cases from the Infectious Disease Hospital in Kolkata during the period of 1999–2019. We used Generalised Additive Modelling to extract the non-linear relationship between cholera and different climatic factors; temperature, rainfall and sea surface temperature (SST). Further, we have used cross-correlation lag analysis to identify the peak associated lag times, and negative binomial regression to quantify the influence of seasonal timing on the magnitude of seasonal cholera cases.
Results
Our findings revealed a dual-peak seasonality in Kolkata cholera cases with a separate summer and monsoon peak. Temperature was the only significant factor associated with summer cholera (mean temperature of 30.3°C associated with RR of 3.8) while rainfall was found to be the main driver of monsoon cholera (550mm total monthly rainfall associated with RR of 3.38). Both variables demonstrated considerable non-linear relationships. Variations in SST appear not to have any significant effect on the occurrence of cholera cases in either season. We found an optimal lag association between temperature and summer cholera of 7 weeks, compared with a much shorter lag of 3 weeks between rainfall and monsoon cholera. Early summers were significantly associated with the magnitude of summer cholera however early monsoons were not associated with monsoon cholera magnitude.
Conclusions
Kolkata exhibits a dual-peak phenomenon with independent mediating factors. We suggest that the summer peak is due to increased bacterial concentration in urban water bodies, while the monsoon peak is driven by contaminated flood waters. Our findings suggest that inventions designed to reduce cholera transmission should be tailored to the appropriate season.
Multi-Criteria Decision-Making Approach with Fuzzy Analytic Hierarchy Process Sets for The Structure on Transactional Distance
Authors: KANDEMİR Bülent , Çakmak Ebru Kılıç
Published: March 2023

The Transactional Distance Theory is a global theory that defines the items that should be found in distance education environments. Structure, which is one of the items of this theory, refers to the degree of flexibility that defines the ability of a course or program to meet individual student needs. In today's distance education approach, the subjective ideas of the designers are effective in the planning of the structural dimension. However, the question of how each item of the structure size affects the online environment and each other has still not been answered. In addition, the difficulties experienced in planning the structural dimension (structuring of online teaching) raise the question of how much each infrastructure item affects online teaching. This study arose from the need to understand how items of a critical dimension, such as structure, in distance education should be constructed objectively. With this study, the weight vector carried by each item related to the structural dimension in distance education was calculated. The Fuzzy Analytic Hierarchy Process, one of the multi-criteria decision-making approaches, was used in the calculation. The linguistic scale used in this method was effective in the preference of the Fuzzy Analytic Hierarchy Process. The linguistic scale enabled decision-makers to make correct binary decisions free from uncertainty and prejudices. At the end of the study, the weight vectors of 77 sub-items were calculated under 5 main items related to structure in online learning.
Identification of compound heterozygous deletions in the WWOX gene caused WOREE syndrome by whole exome sequencing
Authors: Dong xing-sheng , Wen Xiao-jun , Zhang Sheng , Wang De-gang , Xiong Yi , Li Zhi-ming
Published: March 2023

Background
WWOXbiallelic and loss-of-function pathogenic variants cause WWOX-related epileptic encephalopathy (WOREE syndrome), which has been reported in 60 patients to date. In this study, we report on a WOREE syndrome patient who presented with early-onset refractory seizures and global neurodevelopmental delay and died at the age of two and a half years.
Methods
We present clinical and molecular findings in the patient, including biallelic pathogenic variants in the WWOX gene. We employed different molecular approaches, such as whole exon sequencing, quantitative real-time polymerase chain reaction (PCR), and whole-genome sequencing, to identify the genetic defects. The breakpoints were determined through gap PCR and Sanger sequencing.
Result
Whole exon sequencing revealed homozygous exon 6 deletions in the WWOX gene in the proband. Quantitative real-time PCR confirmed that the deletions were inherited from each parent. However, using whole-genome sequencing, we identified three larger deletions (intron 5, exon 6, and exon 6-8) involving the WWOX gene in the proband, with deletion sizes of 13,261, 53,904, and 177,200 bp. The exact breakpoints were confirmed through gap PCR and Sanger sequencing. We found that the proband inherited the discontinuous deletion of intron 5 and exon 6 from the father, and the exons 6-8 deletion from the mother using gap PCR.
Conclusion
Our findings extend the variant spectrum of WOREE syndrome and support the critical role of the WWOX gene in neural development.
An artificial intelligence’s interpretation of complex high-resolution in situ transmission electron microscopy data
Authors: Wang Xingzhi , Yan Chang , Ondry Justin , Ercius Peter , Alivisatos A. Paul
Published: March 2023

In situ transmission electron microscopy (TEM) has enabled researchers to visualize complicated nano- and atomic-scale processes with sub-Angstrom spatial resolution and millisecond time resolution. These processes are often highly dynamical and can be time-consuming to analyze and interpret. Here, we report how variational autoencoders (VAEs), a deep learning algorithm, can provide an artificial intelligence’s interpretation of high-resolution in situ TEM data by condensing and deconvoluting complicated atomic-scale dynamics into a latent space with reduced dimensionality. In this work, we designed a VAEs model with high latent dimensions capable of deconvoluting information from complex high-resolution TEM data. We demonstrate how VAEs with high latent dimensions trained on atomically resolved TEM images of lead sulfide (PbS) nanocrystals is able to capture movements and perturbations of periodic lattices in both simulated and real in situ TEM data. The VAEs model shows capability of detecting and deconvoluting dynamical nanoscale physical processes, such as the rotation of crystal lattices and intraparticle ripening during the annealing of semiconductor nanocrystals. With the help of the VAEs model, we can identify an in situ observation that can serve as a direct experimental evidence of the existence of intraparticle ripening, a process so far has not been recorded under atomically-resolved in situ TEM for colloidal semiconductor nanocrystals. The VAEs model provides a potent tool for facilitating the analysis and interpretation of complex in situ TEM data as a part of an autonomous experimental workflow. It also shows potential to identify unexpected phenomena during the data analysis.
Preparation and evaluation of Orange Fruit Reference Extract based on the principles of Q-markers-A general procedure for establishing Herbal Reference Extracts used for identification
Authors: Zhao WANG , Xiao-yan WANG , Long-gang GUO , Xiao-wen HU , Hong-yu JIN , MA Shuang-cheng
Published: March 2023

Background
Herbal Reference Extracts (HREs) have been used for the overall quality control (QC) of Traditional Chinese Medicines (TCMs) and used as an effective strategy for solving the shortage of reference standards in quality evaluation of TCMs in recently years. But the preparation and evaluation of it has rarely been reported. The ideal HREs should be a combination of Chemical Reference (CR) and Efficacy Reference (ER). However, it is not realistic to achieve "completely extracted" of TCMs at the present stage. Quality markers (Q-markers) provides a series of effective and scientific strategies for QC of TCMs. And Q-markers-based HREs should be a meaningful attempt to promote the standardization of quality evaluation system for TCMs.
Purpose
Preparation adequate HREs based on the principles of Q-markers, and used for quality evaluation of relevant preparation products. Then propose the general procedure for establishing HREs used for identification.
Methods
The authenticity, specificity, consistency and stability (ASCS) were the four essential principles of HREs. In this study, we chose Aurantii Fructus as an example, Firstly, selected 7 Q-markers of it which has the properties of specificity, effectiveness and testability based on the combination of analytic hierarchy process and entropy weight method (AHP-EWM). Secondly, preparated its reference extract which is called Orange Fruit Reference Extract (OFRE) based on ASCS and its Q-markers. Thirdly, established the QC method of OFRE according to its usage requirements. And finally, demonstrated its application of the thin layer chromatography (TLC) identification and characteristic chromatogram identification in the Orange fruit formula granule (or called Zhiqiao Peifangkeli, ZQPK).
Results
Compared with the Herbal Reference Substance (HRS) which with characteristic appearance or morphological structure, OFRE can be used for TLC identification of ZQPK conveniently, without complicated extraction or purification steps. And in the analysis of characteristic chromatogram of ZQPK, the OFRE can provid a rather simple profile, the main naringin, neohesperidin, nobiletin and tangeretin were clearly separated, which indicated that the OFRE could be used to identify the characteristic chromatogram of ZQPK and reduce the use of Chemical Reference Substance (CRS). And finally, we propose the general procedure for establishing HREs used for identification.
Conclusion
In summary, Q-markers-based HREs is feasibility, and should have a broader application prospect. And this research concept can serve as a reference for study on preparation, evaluation and application of HREs used for identification.
A Bibliometric Analysis of Toxicological Impacts of Microplastics in the Environment.
Authors: Mittal Nishu , Tiwari Neeraj , Singh Dhananjay , Tripathi Prabhanshu , Sharma Sapna
Published: March 2023

Plastic has been known as an artificial polymer whereas environmental microplastics become a global concern. Microplastics are reported to cause immunotoxicity in human through gut deposition and entering the bloodstream. This study is a comprehensive indication of the recent research on microplastics toxicity in the gastrointestinal system. We performed bibliographic analysis using VOS viewer software, and analyzed the data received on microplastics and their impact on gut health which has grown exponentially since 2016. Recent findings also support the microplastic toxicity in combination with heavy metals. The smaller particle size and other factors enhanced the adsorption ability of environmental contamination such as heavy metals on microplastic which increased their bioaccumulation. Such toxic complexes of heavy metals and microplastic are a concern to natural ecosystems, so recent findings of environmental biologists are more focused on it. Few reports also demonstrated, the biofilm formation on microplastic surfaces which might cause greater environmental as well as human health risks. Notably, terms of determining the microplastics in human tissues through several analytical techniques are still limited to some extent. Future research should be focused on the quantification of microplastics in human tissues, the combined effect of microplastics with other contaminants, and their effects on the pre-existing diseases. This study boosts understanding of the potential impacts of microplastic and nano-plastic toxicity in the human gastrointestinal system.