bluuebunny/crossref_metadata_2025 huggingface dataset:
BASIS OF FUNCTIONING OF THE QUALITY MANAGEMENT SYSTEM
Authors:   Kazan National Research Technological University, Girfanova Elena Y.
Published: December 2024

Leading global organizations have already formed a number of quality management principles, following which, it is possible to form a competent policy in the field of quality within the enterprise and achieve successful results. Quality itself is a complex concept and includes a set of characteristics, properties and parameters that consumers expect to see in the context of satisfying their needs.
RESEARCH OF COMPETITIVENESS IN THE MARKET OF AGRO-INDUSTRIAL (AGRICULTURAL) PRODUCTS
Authors:   FGBOU VO Chechen State University named after A. A. Kadyrov, Eskhadzhieva Khadishat Kh. , Amadaev Anzor A. ,   FGBUN “ Comprehensive Scientific Research Institute of the Russian Academy of Sciences named after H. I. Ibragimov, Chagaeva Malika V. ,   Grozny State Petroleum Technical University named after Academician M. D. Millionshchikov
Published: December 2024

Speaking about what measures can be taken to effectively increase the market competitiveness of agricultural products, most believe that they can focus on the following aspects: such as promoting largescale agricultural product bases, regionalization and specialization; accelerating the development of leading agricultural production enterprises; creating brands, creating well-known brands and increasing the popularity of agricultural products products; optimization of the structure of agricultural products and improvement of the quality of agricultural products; development of diversified agricultural products. This article discusses the topic of competitiveness in the agricultural products market.
THE IMPORTANCE OF USING COMPUTER SOFTWARE TECHNOLOGIES IN MODERN ENTERPRISES
Authors:   Grozny State Petroleum Technical University named after Academician M. D. Millionshchikov, Magamadova Tabarik S. , Dadaeva Rezeda I. ,   Grozny State Petroleum Technical University named after Academician M. D. Millionshchikov
Published: December 2024

Along with computer technologies that are widely used in various fields, software is used in many enterprises. In modern enterprises, the use of computer software has become commonplace. It not only allows enterprises to carry out unified management, but also plays a positive role in expanding their marketing business. This article discusses the use of computer technology in a modern enterprise.
Liquid–liquid phase separation in neurodegenerative diseases: An updated understanding
Authors: Zhou Yiming , Chen Xinlu , Liu Cihang , Wang Ying , Xia Tianjiao , Gu Xiaoping
Published: December 2024

Liquid–liquid phase separation (LLPS), once understood merely as a physicochemical phenomenon, has emerged over the past decade as a critical player in life processes. LLPS provides a novel framework for understanding the structure, function, and spatiotemporal regulation of intracellular biomolecules. Through LLPS, biomolecules within cells can spontaneously assemble into membraneless compartments, which allow precise regulation of biochemical reactions and influence critical cellular processes such as signal transduction and gene expression. Despite its recognized significance in basic biological research, the role of LLPS in human disease is still an area worthy of continued exploration. Currently, the most studied disorders in relation to LLPS are neurodegenerative diseases and cancer. In neurodegenerative diseases, LLPS is closely linked to protein misfolding and aggregation, processes that can lead to the formation of toxic assemblies, ultimately causing neuronal damage and death. In cancer, aberrant LLPS may contribute to the dysregulation of signaling pathways, promoting uncontrolled cell proliferation and metastasis. This review highlights recent advances regarding the role of LLPS in the pathogenesis of neurodegenerative diseases, discussing its function in these pathological conditions and proposing directions for future research. As research progresses, the potential role of LLPS in other human diseases will likely be uncovered, offering new avenues for diagnosis and therapy. Therefore, further investigation into the mechanisms of LLPS and its involvement in disease pathology will be crucial for advancing our understanding of human health and disease.
68Ga-PSMA PET CT/MRI in the initial diagnosis and staging of prostate cancer: A review
Authors: Akinmuleya Oluwatobi I. , Cohen Philip F. , Kairemo Kalevi
Published: December 2024

Prostate-specific membrane antigen-positron emission tomography (PSMA-PET) imaging has demonstrated potential in addressing prostate cancer (PCa) diagnostic difficulties. According to current guidelines, gallium-68 (68Ga)-PSMA-PET is used as an adjunct to traditional imaging modalities in patients with primary PCa. The purpose of this review, conducted using Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, is to give an overview of studies that have examined the role of 68Ga-PSMA in the initial diagnosis of PCa, its performance in TNM staging, its correlation with prostate-specific antigen (PSA) levels, targeted biopsies, and the International Society of Urological Pathology (ISUP) scores using computed tomography (CT) or magnetic resonance imaging (MRI). The findings demonstrate that, in addition to MRI alone, combining 68Ga-PSMA-PET with MRI-targeted biopsy improves the initial identification of clinically significant prostate cancer (csPCa), particularly for ambiguous prostate imaging-reporting and data system (PI-RADS) three lesions. 68Ga-PSMA-PET/CT is useful when MRI results for csPCa are uncertain, but consistent techniques are required. Regarding risk assessment and therapy planning, 68Ga-PSMA-PET has a strong correlation with both PSA levels and ISUP scores. It accurately detects primary PCa lesions, making it suitable for high-risk patients. In 68Ga-PSMA-PET, higher maximum standardized uptake value (SUVmax) readings are linked to more aggressive illness. For N and M staging, 68Ga-PSMA-PET/CT is more sensitive and specific than conventional imaging; however, for T-staging, multiparametric MRI (mpMRI) provides better accuracy. 68Ga-PSMA-PET/MRI shows improved accuracy for primary PCa detection compared to mpMRI alone. Challenges include the lack of standardized SUVmax cutoff values. 68Ga-PSMA-PET is useful for the initial diagnosis and staging of PCa, complementing MRI, although further research is needed to standardize imaging techniques and interpretations.
Single-nucleotide polymorphism rs670 in the promoter region of the apolipoprotein A-I gene
Authors: Dionys Rodrigues da Costa Mac , Ribeiro Duque Bruna , Maria Lima Pinheiro Natasha , Maria Martins Teixeira Izabell , Paula Magalhães Emanuel , Ramon Cunha da Silva Felipe , Edson da Silva Mateus , Maria Costa Martins Alice , Róseo Paula Pessoa Bezerra de Menezes Ramon , Lima Sampaio Tiago
Published: December 2024

Apolipoprotein A-I (Apo A-I) plays a central role in the function of high-density lipoprotein (HDL). The rs670 single-nucleotide polymorphism (SNP) was identified as a cytosine-to-thymine (C>T) transition in a cytosine–phosphate–guanine site within the promoter region of APOA1. Given its location, studies have hypothesized that this polymorphism may influence APOA1 expression, potentially impacting lipid and carbohydrate metabolism. The aim of this integrative review was to summarize all observational and experimental studies on the rs670 SNP available in the Scopus, ScienceDirect, dbSNP, and LitVar2 databases up to July 2024. In total, 162 articles were identified, of which 28 met the inclusion criteria. Most studies originated from Asia and were published between 2009 and 2023. Of the selected studies, 14 (50%) examined the association of the rs670 SNP with metabolic disorders. Among these, eight (28.57%) reported an association between the polymorphic allele and alterations in lipid profiles, proinflammatory markers, and insulin resistance. The remaining studies explored associations between the polymorphic allele and ischemic events, pharmacological therapies, diet, neurodegenerative diseases, pancreatitis, and breast cancer. The rs670 SNP occurs in more than 20% of the global population. Its position within the promoter region enables it to potentially regulate the APO cluster on chromosome 11. This review underscores the need for further investigation into the impact of this polymorphism on gene expression and its role in the pathogenesis of metabolic syndrome, cardiovascular disease, and cancer.
Association of high-density lipoprotein-related inflammatory markers with suicidal ideation: Data from the NHANES 2015 – 2023 survey
Authors: Sun Zhonghua , Chen Sen , Xu Yameng , Qu Chen
Published: December 2024

Suicidal ideation (SI) is a strong predictor of suicide risk. High-density lipoprotein (HDL)-related inflammatory indicators, which combine HDL cholesterol (HDL-C) with other inflammation-related markers, provide a comprehensive assessment of the body’s inflammatory, immune, and metabolic states. However, limited research has examined the association between HDL-related inflammatory indicators and SI. This study analyzed data from 14,554 participants, including 588 individuals with SI, using information from the 2015 – 2023 National Health and Nutrition Examination Survey. SI was evaluated using the ninth item of the Patient Health Questionnaire-9. A weighted approach was applied to logistic regression, restricted cubic spline, and subgroup analyses to explore the relationship between six HDL-related inflammatory indicators and SI. In addition, weighted quantile sum regression was employed to account for the interactions among inflammatory markers and their influence on the outcomes. Among the various single-marker models, only high-sensitivity C-reactive protein/HDL-C (CHR) consistently demonstrated a significant linear association with SI. In Model 3 of the logistic regression analysis, the odds ratio with a 95% confidence interval was 1.11 (1.02, 1.21). Mixture analyses further identified CHR as the primary factor contributing to the increased prevalence of SI. This study provides the first epidemiological evidence linking multiple novel inflammatory markers to SI, identifying CHR as the most critical factor. Further prospective studies are needed to confirm this causal relationship.
EpCAM-targeting cancer immunotherapies: Evidence from clinical studies and the way forward
Authors: Makafui Dogbey Dennis , Andong-Koung-Edzidzi Ursula-Claire , Atlegang Molope Gomolemo , Singh Jesmika , Lovemore Bvudzijena Tatenda , Naran Krupa , Barth Stefan
Published: December 2024

Overexpressed cell-surface receptors play a crucial role as biomarkers in immunodiagnostics and immunotherapy. Epithelial cell adhesion molecule (EpCAM) is a 40 kDa cell-membrane glycoprotein associated with cell differentiation, survival, migration, and proliferation. The structure, biological functions, and role of EpCAM in tumorigenesis have been extensively studied, including its involvement in metastasis, tumor cellular signaling, and pro-proliferating pathways. It is differentially overexpressed on the surface of several tumor types, with substantial evidence suggesting a positive correlation with poor disease prognosis and overall survival. Consequently, it has emerged as a significant target for immunotherapy development, with some of them already entering clinical evaluation and one having been approved by the U.S. Food and Drug Administration to date. Pre-clinical and clinical studies evaluating anti-EpCAM immunotherapies have reported diverse outcomes necessitating critical assessment in considering future therapy development. EpCAM-targeting immunotherapies including monoclonal antibodies, adoptive cell transfer therapy, immunocytokines, recombinant immunotoxin, and bispecific T-cell engagers have been studied as monotherapy or in combination with other treatments resulting in improved outcomes. Depending on disease status, EpCAM-targeting therapies are studied in adjuvant and neoadjuvant settings by integrating the clinical features of patients and treatment intent. However, the wide range of adverse events reported in various unsuccessful clinical studies has implications for future clinical trial designs, patient stratification, and endpoint criteria measures. This review examines the efficacy and toxicity profiles of anti-EpCAM immunotherapeutic approaches that have undergone clinical investigations for the treatment of antigen-positive malignancies and provides perspectives to guide future research and development strategies toward precision medicine.
Coupling Coordination Analysis between Total Factor Productivity and Digital Economy in China’s Agriculture
Authors: Gao Shuang , Yamada Masaaki , Gao Dawei , Nie Haisong
Published: December 2024

This study aims to systematically analyze the coupling and coordinated development between the digital economy (DE) and total factor productivity (TFP) in China’s agricultural sector, focusing on their impact on regional agricultural advancement. Using a comprehensive dataset from 31 Chinese provinces covering the period from 2014 to 2021, we apply the EBM model, entropy weight method, and coupling coordination degree model to assess TFP-DE interactions. To capture spatial-temporal dynamics and regional disparities, we employ kernel density estimation, Moran’s I index, the Dagum Gini coefficient, and an obstacle degree model. The findings reveal an initial phase of “multipolarization” in TFP-DE coordination, which gradually stabilizes towards preliminary coordination levels. Despite this progress, significant regional imbalances persist, particularly in central and western provinces where “low-low” clusters dominate, in contrast to the “high-high” clusters in eastern regions. While disparities in coordination have narrowed in eastern areas, they continue to widen across central and western regions. The primary obstacles have shifted from foundational infrastructure to challenges directly associated with DE and TFP. This study underscores the necessity of region-specific policies to address these disparities, particularly in underdeveloped areas, to enhance agricultural productivity through digital integration. The findings provide a strategic foundation for policymakers to foster balanced and sustainable growth, contributing to China’s broader goals for agricultural modernization.
Circumference, Minimum Degree and Clique Number
Authors: Yuan Long-Tu
Published: December 2024

The circumference and the clique number of a graph is the length of a longest cycle and the largest order of a clique in it respectively. We show that the circumference of a 2-connected non-Hamiltonian graph $G$ is at least the sum of its clique number and minimum degree unless $G$ is one of two specific graphs.
The Rational Number Game
Authors: Bowler Nathan , Gut Florian
Published: December 2024

We investigate a game played between two players, Maker and Breaker, on a countably infinite complete graph where the vertices are the rational numbers. The players alternately claim unclaimed edges. It is Maker's goal to have after countably many turns a complete infinite graph contained in her coloured edges where the vertex set of the subgraph is order-isomorphic to the rationals. It is Breaker's goal to prevent Maker from achieving this.We prove that there is a winning strategy for Maker in this game. We also prove that there is a winning strategy for Breaker in the game where Maker must additionally make the vertex set of her complete graph dense in the rational numbers.
Unraveling the therapeutic potential of Calculus Bovis in liver cancer: A novel step for targeted cancer treatment
Authors: Chen Xing-Yu , Lan Xiang
Published: December 2024

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally, and effective treatments are urgently needed. The present study aimed to investigate the inhibitory effect of Calculus Bovis (CB) on liver cancer and the underlying mechanisms. CB inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway, thereby suppressing the proliferation of liver cancer cells. The inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments (detailed by Huang et al ). The present study provides a theoretical basis for the application of CB for the treatment of liver cancer, providing new avenues for liver cancer treatment.
Assessing Information Literacy Competencies of Fresh Students at Bauchi State University Gadau: Insights from the Library Environment
Authors: Mohammed Adamu , Yusuf Asma’u Muhammad
Published: December 2024

The purpose of this study is to understand the levels of freshers’ information literacy skills at Bauchi State University Gadau, Nigeria. This study was conducted using cross sectional survey research method A questionnaire developed was used for data collection, and the data were analyzed using descriptive statistics of percentages and frequencies that was described in chart formats. The target population in this study comprise of 3,236 freshers during the 2022/2023 academic session of Bauchi State University Gadau. Based on the simple random sampling method, the sample size is three hundred and forty-four (344) as determined by the statistical formulation provided by Yamane (1967). The findings showed that the freshers acquire information literacy skills during orientation, workshops or from course syllabus. the study also found that freshers at Bauchi State University Gadau do not have the proper understanding of the concept of information literacy and cannot identify credible sources of information. Thus, this study recommends that more formal training programmes concerning information literacy skills need to be integrated into freshers’ curriculum to support the students learning and can improve their understanding of the concept of information literacy skills.
Application of Social Media Networking (SMN) To Library and Information Service Delivery in Nigerian Academic Libraries
Authors: Olubiyo Peter Olubunmi
Published: December 2024

The paper expounds the meaning of social networking as a process of building relationship among group of people with common interest and ideology. Social networking is achieved through the use of social media. Social media is an essential tool for library to explore in its unquenchable passion to pervade society with relevant and current information. Social media offers a powerful and pervasive communications platform that is radically changing the way we interact. With its viable feedback mechanism, social networking could assist library to respond to queries, current awareness, SDI, new arrival, send out reading list, alert on overdue among other services. Brief Historical Trace of social media were stated. Publications of a university’s research findings and intellectual contents are easier shared with social media. The challenges on the use of Social Media Networking (SMN) for Library Service Delivery were discussed as Copyright issues which is a common challenge when making use of social media to disseminate information and this is not restricted to information disseminated in print format alone but it also cuts across information disseminated in audio and video format. Cost of carrying out library services using social network sites could be enormous and other challenges were discussed in the paper. It was recommended that social media should be made accessible to user information needs of online users to help libraries get closer to the society.
THE ATTENUATION CHARACTERISTICS OF DIFFERENT FREQUENCY COMPONENTS OF ACOUSTIC EMISSION SIGNAL DURING PROPAGATION IN ELM AND PINE WOOD
Authors: DU KUN , WANG YOULI , ZHANG ZHIHENG , LI MING , FANG SAIYING
Published: December 2024

In order to gain a deeper understanding of the attenuation characteristics of different frequency components of acoustic emission signal when propagating in wood, this research conduct pencil lead fracture experiments on the surface of elm and pine specimen. Original AE signals acquired by different sensors are decomposed using 5-level wavelet transform, the attenuation characteristics of different frequency components are studied, and the acoustic emission source is located according to the energy of different frequency components. The results indicate that the propagation distance is the main factor affecting the attenuation of AE signals. The longer the propagation distance, the greater the degree of attenuation. The attenuation characteristics of high-frequency components of acoustic emission signals deviate from the ideal attenuation model after the propagation distance greater than 10 cm. The higher the frequency components of acoustic emission signals, the faster they attenuatewhen propagation in elm and pine specimen.
Análisis del Contenido de Azufre (S) en la Gasolina por el Método de Hidrodesulfuración
Authors: Peña Murillo Sandra , Zambrano Nevárez Eddie , Villa Manosalvas Gonzalo , Baquerizo Figueroa Julio , Lindao Rodríguez William Kevin
Published: December 2024

A lo largo de los años, el contenido de azufre en la gasolina ha impactado directamente en las emisiones de dióxido de azufre (SO₂), uno de los contaminantes atmosféricos más perjudiciales para el medio ambiente y la salud humana. Este compuesto no solo contribuye significativamente a la contaminación del aire, sino que también reduce el rendimiento y la vida útil de los equipos que utilizan este combustible. Ante esta problemática, el objetivo de la presente investigación es analizar el contenido de azufre en la gasolina mediante el método de hidrodesulfuración (HDS), a través de una revisión bibliográfica exhaustiva. Para ello, se seleccionaron fuentes relevantes aplicando criterios de inclusión y exclusión que aseguran la calidad metodológica de los estudios consultados. La hidrodesulfuración se presenta como una técnica eficaz para reducir el contenido de azufre en combustibles fósiles, permitiendo alcanzar niveles que cumplen con las normativas ambientales más estrictas. Tras la recopilación de los artículos, se realizó una revisión crítica, evaluando los métodos de hidrodesulfuración y extrayendo información clave sobre su eficacia y eficiencia en comparación con otras técnicas. Se identificaron patrones y contrastaron hallazgos en los estudios científicos seleccionados, lo que permitió construir una base sólida para el análisis del contenido de azufre en la gasolina. Este proceso resaltó las contribuciones significativas que el método HDS ofrece, destacando su capacidad para minimizar las emisiones contaminantes. De esta manera, la investigación subraya la importancia de aplicar tecnologías de tratamiento que reduzcan el contenido de azufre en la gasolina, mitigando sus efectos ambientales.
El Papel de las Prácticas Preprofesionales en el Desarrollo de la Adaptabilidad de los Estudiantes a los Cambios en el Mercado Laboral Durante el Período Marzo - Septiembre 2024
Authors: Arevalo Cordovilla Braulio Christian , Campoverde Pico Jennifer Lissete , Andaluz Leon Delia Maria
Published: December 2024

Este estudio analiza el impacto de las prácticas preprofesionales en el desarrollo de la adaptabilidad y habilidades técnicas de estudiantes de ingeniería entre marzo y septiembre de 2024. En un mercado laboral en constante cambio, estas prácticas permiten a los estudiantes adquirir competencias clave mediante la exposición a entornos laborales reales. El 85% de los encuestados reportó mejoras en el manejo de software especializado, mientras que el 78% fortaleció su experiencia con equipos tecnológicos y maquinaria industrial. El acceso a tecnologías avanzadas y la resolución de problemas complejos fueron determinantes para su formación adaptativa. Un 82% de los estudiantes enfrentó situaciones inesperadas semanalmente, desarrollando resiliencia y capacidad de adaptación, habilidades confirmadas por supervisores empresariales que destacaron su actitud hacia el aprendizaje continuo. La duración de las prácticas también influyó en la adquisición de competencias, observándose mayores beneficios en programas extendidos. Los resultados reflejan que las prácticas preprofesionales no solo mejoran habilidades técnicas, sino que también preparan a los estudiantes para responder de manera efectiva a los desafíos del mercado laboral contemporáneo. Se recomienda fortalecer la duración y calidad de estos programas para maximizar su impacto formativo y profesional.
Regulación Emocional en Niños con Trastorno por Déficit de Atención e Hiperactividad (TDAH), en Educación Inicial
Authors: González Vázquez Mariela Elizabeth , Barrozo Murillo Valeria Alexandra , Galarza Alejandro María de Lourdes , Castillo Ureña Marilyn del Carmen
Published: December 2024

Este artículo tuvo como objetivo general analizar la regulación emocional en niños con Trastorno por Déficit de Atención e Hiperactividad (TDAH) en educación inicial, producto de la revisión de investigaciones en el período del 2018 a 2023 en la plataforma Scopus. El artículo exploró cómo el manejo de impulsividad y reacciones emocionales es clave para el desarrollo académico y social de estos niños. La metodología empleada fue de revisión sistemática de artículos que abordaron estrategias de regulación emocional para niños con TDAH en contextos educativos. Los resultados muestran un aumento en la producción de estudios que destacan la importancia de la regulación emocional, con Estados Unidos liderando las investigaciones. Las intervenciones, como la escritura y estrategias socioemocionales, mejoraron el autocontrol, autoestima y adaptación social de los niños con TDAH. En la discusión de resultados, se resalta la necesidad de adaptar estrategias pedagógicas a cada contexto cultural y de capacitar a los docentes en técnicas de regulación emocional. En conclusión, el estudio confirma que los programas de regulación emocional no solo benefician el rendimiento académico, sino que también promueven un desarrollo integral en niños con TDAH. Se recomienda continuar investigando para optimar estas estrategias, permitiendo entornos de aprendizaje inclusivos y eficaces.
Relación del Estado Nutricional con Resultados Adversos Cardiovasculares y Dislipidemia en la Población del Sector Rural Huachi Grande, un Estudio de Prevalencias
Authors: Sancho Cando Erick David , Sancho Cando Mario Andrés , Vera Barberan Oliver Steeven , Acosta Monje Pamela Lisbeth , Morocho Borja Telmo Eduardo
Published: December 2024

El estado nutricional de una persona depende del tipo de alimentación, metabolismo, actividad física entre otros factores; el índice de masa corporal es un dato antropométrico muy utilizado en la práctica médica, actualmente el sobrepeso como la desnutrición se han convertido en enfermedades con alta prevalencia a nivel mundial; la malnutrición y el desarrollo de enfermedades crónicas no transmisibles están estrechamente relacionadas, convirtiéndose el sobrepeso y obesidad en un factor de riesgo cardiovascular modificable; además se relacionan con el desarrollo de dislipidemias que empeoran el estado de salud de la persona que la padece; en Ecuador hay una alta prevalencia de enfermedades cardiovasculares, siendo la primera causa de muerte desde el 2021 hasta la actualidad; los habitantes de los sectores rurales al no tener una educación nutricional adecuada y no realizarse chequeos de salud de manera subsecuente desarrollan dichas enfermedades por lo que es importante realizar estudios que permitan conocer la situación de salud. El presente artículo se trata de un estudio no experimental, descriptivo, transversal con enfoque cuantitativo que busca exponer la prevalencia de enfermedades cardiovasculares y dislipidemia según el índice de masa corporal de los participantes, en los habitantes de la población rural de la parroquia Huachi Grande en el mes de Julio del año 2024.
An Action Research for Implementing Affective Teaching Strategies for Reducing Anxiety and Increasing Motivation in EFL Beginner Learners at Campus Liberia of Universidad Nacional (UNA) in Guanacaste, Costa Rica
Authors: Ruiz Sequeira Carlos Gerardo , Montero Cortes Tobias , Moya Bello María Fernanda , Brenes Zúñiga Jorge
Published: December 2024

This study explores the impact of teacher feedback and behavior on student motivation and performance in English as a Foreign Language (EFL) classrooms. It highlights the negative effects of harsh feedback and emotional abuse, contrasted with the positive outcomes of supportive teacher-student interactions. Using a mixed-methods approach involving surveys and classroom observations of 64 beginner EFL students, the research identifies various self-motivation techniques students use, such as positive self-statements and relaxation methods. The study also evaluates the effectiveness of a pedagogic proposal incorporating five affective teaching strategies, which significantly enhance student engagement and learning. The findings underscore the importance of a positive and empathetic classroom environment, recommending that teachers and educational institutions adopt supportive and innovative teaching methods to improve EFL education outcomes.
Energy and exergy evaluation in a densified biomass burner using cocoa shells, intended for air heating for the artificial drying of food
Authors: Castillo-Leon N. Y. , Rincon-Quintero A. D. , Mosquera-Clavijo A. A. , Suarez-Lopez Carolina Andrea , Betancur-Arboleda Luis Alonso , Alfonso del Portillo-Valdes Luis
Published: December 2024

Residual biomass as a renewable resource provides alternatives for energy generation, turning a problem into an opportunity for the industry. This study aims to analyze the energy and exergy performance of a biomass burner that uses cocoa shells as fuel for air heating and subsequent artificial drying of food. The study involves a conventional exergy analysis evaluating the energy performance of the equipment and proposing improvements to enhance the thermal efficiency of the system. The research consists of six phases: it begins with defining the input data of the system, followed by determining the thermodynamic properties of the working fluid (air), the exergies of the biofuel and the working fluid are calculated, energy and exergy balances are performed in the heat exchanger of the burner, and efficiencies are obtained. Finally, a sensitivity analysis is conducted to understand the burner’s behavior under different scenarios. The results showed an average exergy efficiency of 9.8%. By increasing energy efficiency in the sensitivity analysis, the outlet temperature rises to 164°C; however, exergy destruction decreases by 48.7%. One of the significant conclusions of this study proposes modifying the coil design to improve the exergy efficiency of the system due to its heat transfer capacity to the air.
Mastery Level of Interpersonal and Intrapersonal Skills Among Prospective FPTV Teachers
Authors: Abdullah Nurmina , Rahim Mohd Bekri
Published: December 2024

Education transformation certainly makes the role and duties of teachers larger, more challenging and more complex. Effective interpersonal and intrapersonal communication skills are extremely important for a teacher in the delivery of education, classroom management and student interaction. This study aimed to examine the level of mastery of interpersonal and intrapersonal skills of future teachers on FPTV. The respondents to this study were 175 final year teachers and they covered all the courses offered in FPTV. The questionnaire was used as a research instrument. Data were analyzed using statistics in terms of frequency, percentage, mean score, standard deviation, Independent T-Test and Pearson correlation. The findings of the study have shown that the highest level of mastery of interpersonal skills is teamwork and the highest level of mastery of intrapersonal skills is the domain of personality. However, presentation skills, listening skills, emotional intelligence and spiritual intelligence are at a moderate level. The study also reported that there was no significant difference in the level of interpersonal and intrapersonal skills based on gender. Finally, a few proposals for future studies were made, including making comparisons for skills between teachers teaching at the secondary school level and vocational colleges. It aims to find out the level of skill difference that teachers have in the two kinds of schools. Besides, it is recommended to focus on increasing the number of studies on technical instructors, as the search results indicate a scarcity of research on the level of engineering abilities among technical teachers. Given that BPLTV is a prominent aspect of education in Malaysia, it is imperative to undertake more regular studies on BPLTV teachers.
PENGARUH KUALITAS AUDIT DAN KOMITE AUDIT TERHADAP KECURANGAN LAPORAN KEUANGAN (STUDI EMPIRIS PADA PERUSAHAAN MANUFAKTUR SEKTOR BARANG KONSUMSI PRIMER YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2020-2023)
Authors: Luthfiyyah Alya
Published: December 2024

Financial statement fraud is a high incidence of fraud compared to corruption and misuse of assets. The purpose of this research is how audit quality, audit committees and financial statement fraud are, how much influence audit quality and audit committees have on financial statement fraud, how much influence audit quality has on financial statement fraud, how much influence the audit committee has on financial statement fraud. The purpose of this study was to determine the effect of audit quality and audit committee on financial statement fraud. The data source used in the study is secondary data from the annual financial statements the study used 240 sample data from 60 companies for 4 years of research. Sampling using non-probability sampling with purposive sampling technique. To measure the effect of the sample, the classic assumption test analysis and panel data regression analysis. The condition of audit quality, audit committees and financial statement fraud in manufacturing companies in the primary consumer goods sector in the sample is in poor condition. The research results show that audit quality has a negative and significant effect on financial statement fraud. Good audit quality can reduce financial statement fraud. Furthermore, the audit committee has no effect and not significant on financial statement fraud, a poor audit committee will increase financial statement fraud. The results of simultaneous testing show that audit quality and the audit committee jointly influence financial statement fraud.
Double “acct”: A Distinct Double-peaked Supernova Matching Pulsational Pair Instability Models
Authors: Angus C. R. , Woosley S. E. , Foley R. J. , Nicholl M. , Villar V. A. , Taggart K. , Pursiainen M. , Ramsden P. , Srivastav S. , Stevance H. F. , Moore T. , Auchettl K. , Hoogendam W. B. , Khetan N. , Yadavalli S. K. , Dimitriadis G. , Gagliano A. , Siebert M. R. , Aamer A. , Boer T. de , Chambers K. C. , Clocchiatti A. , Coulter D. A. , Drout M. R. , Farias D. , Fulton M. D. , Gall C. , Gao H. , Izzo L. , Jones D. O. , Lin C.-C. , Magnier E. A. , Narayan G. , Ramirez-Ruiz E. , Ransome C. L. , Rest A. , Smartt S. J. , Smith K. W.
Published: December 2024

We present multiwavelength data of SN 2020acct, a double-peaked stripped-envelope supernova (SN) in NGC 2981 at ∼150 Mpc. The two peaks are temporally distinct, with maxima separated by 58 rest-frame days and a factor of 20 reduction in flux between. The first is luminous (M

r
 = −18.00 ± 0.02 mag) and blue (g − r = 0.27 ± 0.03 mag) and displays spectroscopic signatures of interaction with hydrogen-free circumstellar material. The second peak is fainter (M

r
 = −17.29 ± 0.03 mag) and has some spectroscopic similarities to an evolved stripped-envelope SN, with strong forbidden [Ca ii] and [O ii] features. No other known double-peaked SN exhibits a light curve similar to that of SN 2020acct. We find the likelihood of two individual SNe occurring in the same star-forming region within that time to be highly improbable, while an implausibly fine-tuned configuration would be required to produce two SNe from a single binary system. We find that the peculiar properties of SN 2020acct match models of pulsational pair instability (PPI), in which the initial peak is produced by collisions of shells of ejected material, shortly followed by core collapse. Pulsations from a star with a 72 M
⊙ helium core provide an excellent match to the double-peaked light curve. The local galactic environment has a metallicity of 0.4 Z
⊙, a level where massive single stars are not expected to retain enough mass to encounter the PPI. However, late binary mergers or a low-metallicity pocket may allow the required core mass. We measure the rate of SN 2020acct–like events to be <3.3 × 10−8 Mpc−3 yr−1 at z = 0.07, or <0.1% of the total core-collapse SN rate.
Burden and predictors of M-pox suspected cases in a rural setting of Cameroon: implications for developing countries
Authors: Nganmegni Flaure Rasana P , Ngo Julienne Louise L , Essomba René G , Nguwoh Philippe S , Metomb Franck S , Epee Emilienne , Mandeng Nadia , Mballa Georges-Alain E , Boum II Yap , Okomo Marie Claire A , Taheu Christian N , Fokam Joseph
Published: December 2024

Introduction: M-pox is a re-emerging pathogen that is spreading rapidly in developing countries, presenting a serious health risk. Data are scarce on M-pox and its determinants in endemic countries such as Cameroon. This study aimed to assess the epidemiological burden and factors linked to the resurgence of M-pox in high-risk communities in Cameroon.
Methodology: A community-based surveillance was conducted from April to October 2022, among 88 individuals at the Ayos Health District (AHD). Participants were interviewed, and cases of M-pox were defined based on World Health Organization (WHO) clinical criteria. Data were analyzed using CSPro v.6.0 and SPSS v.20.0, with p < 0.05 as the statistical significance level.
Results: The overall suspected M-pox cases rate was 25% (22/88). Following logistic regression, history of chickenpox (OR 0.14, p = 0.05); history of smallpox (OR 9.14, p < 0.001), vaccination against poxviruses (p < 0.001), skin infection (OR 210, p < 0.001), upper respiratory infection (p < 0.001), atypical dermatitis (OR 144, p < 0.001), skin allergy (OR 68.57, p < 0.001), contact with an individual suffering from M-pox in the last 14 days before symptoms onset (OR 9.14, p < 0.001), contact with animals in the last 14 days before symptom onset (OR 12.68, p  0.001), regular meal consumption (OR 0.35, p = 0.04), meal-sharing, and handling of bushmeat (p = 0.01) were significantly associated with M-pox infection.
Conclusions: The clinical features of M-pox were common in rural Cameroonian setting, suggesting the need for active surveillance in these high-risk communities.
Can antiviral drugs address the treatment challenges of severe fever with thrombocytopenia syndrome? - a systematic meta-analysis
Authors: Shen Lumeng , Han Mingfang , Lou Jingjing , Shen Wenya , Li Shibo
Published: December 2024

Background: Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease with high mortality and severity rates. However, there is no clear treatment plan, specific effective antiviral drugs, or effective vaccine for SFTS. Recent studies have shown that the therapeutic effect of Ribavirin and other commonly used antiviral drugs such as Favipiravir (T-705), on SFTS is still controversial. This meta-analysis was conducted to evaluate the therapeutic efficacy of antiviral drugs on SFTS.
Methods: Relevant studies were searched from Cochrane Library, Web of Science, Embase. and PubMed from inception to June 30, 2022, and updated to 2023. The study screening, data extraction, and quality assessment were conducted by re-searchers independently. A counterpart assessment tool was used to assess methodological quality, and the Stata15 software was employed to perform meta-analysis.
Results: The meta-analysis included 8 studies consisting of 4692 patients. The results showed no significant difference in the mortality rate of SFTS patients between the antiviral drug group and the control group (HR: 0.85, 95% CI: 0.46–1.59, p = 0.618). Antiviral drugs had no noticeable effect on this disease (RR: 0.93, 95% CI: 0.58–1.48, p = 0.747).
Conclusions: At present, antiviral drugs (Ribavirin and Favipiravir) used routinely in clinics show no positive effect on the treatment of SFTS yet and fail to reduce the mortality rate. On the other hand, clinical studies specifically evaluating viral load found that antiviral drugs were effective in the treatment of SFTS patients with low viral load, but the efficacy was not statistically significant.
Investigation of colistin heteroresistance and the colistin resistance genes mcr-1 to mcr-5 in Escherichia coli and Klebsiella pneumoniae isolates in a tertiary hospital in Turkey
Authors: Afyoncu Erkut , Eryıldız Canan
Published: December 2024

Introduction: Heteroresistance is not detected by traditional antimicrobial susceptibility testing methods and may lead to treatment failures. Investigating the presence of plasmid-mediated colistin resistance genes is important because of the horizontal transmission of the relevant genes between bacterial species. This study aimed to investigate the presence of colistin heteroresistance and the colistin resistance genes mcr-1 to mcr-5 in Escherichia coli and Klebsiella pneumoniae isolates.
Methodology: A total of 254 isolates, including 100 E. coli and 154 K. pneumoniae strains isolated from clinical samples, were included in the study. Colistin susceptibility was evaluated using the broth microdilution method for all strains. Heteroresistance screening was performed using the gradient strip test. Eight strains were evaluated for heteroresistance by population analysis profiling (PAP). The colistin resistance genes mcr-1 to mcr-5 were investigated by multiplex polymerase chain reaction (PCR) in colistin-resistant K. pneumoniae isolates. Multilocus sequence typing (MLST) analysis was performed on two K. pneumoniae strains.
Results: Colistin resistance was not detected in the E. coli isolates and was detected in 16.23% (25/154) of the K. pneumoniae isolates. No heteroresistant bacteria were detected by the gradient strip test or by PAP. All colistin-resistant isolates were negative for the mcr genes. The two isolates analyzed by MLST were ST14 and ST2096.
Conclusions: Periodic follow-up of colistin heteroresistance is useful for administering appropriate antibiotic therapy. In addition, the investigation of colistin resistance genes is important for infection control measures.
Oral traditional Chinese medicine for mild to moderate cases of COVID-19: a network meta-analysis based on RCTs
Authors: Cao Wen , He Nannan , Luo Yannian , Zhang Zhiming
Published: December 2024

Introduction: This systemic review examines the effectiveness and safety of combining traditional Chinese medicine with standard therapy in the treatment of mild to moderate cases of coronavirus disease 2019 (COVID-19).
Methodology: We retrieved articles from PubMed, Web of Science, Cochrane, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, Weipi (VIP), and China Biology Medicine disc (CBM). The deadline for retrieval was 20 August 2022, and it was updated on 1 July 2023. Two researchers worked independently on literature screening, data extraction, and evaluation of the quality of the literature.
Results: A total of 21 randomized controlled trials were included in this review; consisting of 9 articles in English and 12 articles in Chinese. According to the fixed-effects model, the results of the traditional meta-analysis indicated a significantly superior efficacy of oral traditional Chinese medicine combined with standard therapy in treating mild to moderate cases of COVID-19, compared to standard treatment (OR = 1.81, 95% CI: 1.59–2.06), with no increased adverse effects (OR = 1.28, 95% CI: 0.95–1.73). The network meta-analysis results revealed Lianhua Qingke, Toujie Quwen, and Jinhua Qinggan granules as the three best Chinese medicines with the most effective treatment outcomes; while Lianhua Qingwen capsule/granules, Reyanning, and Shufeng Jiedu capsules were the top three Chinese medicines with the fewest side effects.
Conclusions: The efficacy of oral traditional Chinese medicine combined with standard therapy in treating mild to moderate COVID-19 was significantly superior to standard therapy alone. However, the limited quality of evidence reduces the reliability of the meta-analysis.
Detection and characterization of carbapenemase-producing Enterobacteriaceae in cancer patients: first Sri Lankan report of blaVIM in Enterobacteriaceae
Authors: Chathuranga Gayashan , Dissanayake Thushari , Fernando Neluka , Wanigatunge Chandanie Amila
Published: December 2024

Background: Carbapenem-resistant Enterobacteriaceae (CRE) are an important cause of infections in cancer patients. The proportion of carbapenem resistance and the types of carbapenemase-encoding genes in Enterobacteriaceae isolated from cancer patients were determined in this study.
Methodology: Bacteria isolated from adult, in-ward cancer patients with lower respiratory tract infections (LRTI), skin and soft tissue infections (SSTI), or urinary tract infections (UTI) were included in the study. Enterobacteriaceae were identified up to the species level by API® 20E test kits. Carbapenem resistance was defined as non-susceptibility to either imipenem or meropenem in the disc diffusion test. Major carbapenemase-encoding genes (blaKPC, blaNDM, blaOXA-48, blaIMP, and blaVIM) were detected by the GeneXpert® Carba-R real-time PCR instrument.
Results: Enterobacteriaceae comprised 57% (94/165) of the bacterial isolates. Carbapenem resistance among Enterobacteriaceae was 46.8% (44/94). Klebsiella pneumoniae (65.9%, 29/44) was the predominant CRE isolate followed by Escherichia coli (25%, 11/44). The majority of CRE isolates (72.7%, 32/44) had a meropenem MIC of ≥ 32 µg/mL. Carbapenemase-encoding genes were identified in 43 of the 44 CRE isolates. blaNDM was the most prevalent carbapenemase-encoding gene and was detected in 67.4% (29/43) of Enterobacteriaceae isolates. No isolate was positive for blaIMP. Sixteen (37.2%) isolates co-harbored more than one carbapenemase-encoding gene. Two Enterobacteriaceae isolates were found to harbor blaVIM.
Conclusions: Nearly all CRE isolated in this study were carbapenemase producers. This study documented the emergence of blaVIM harboring Enterobacteriaceae for the first time in Sri Lanka.
Guerre et « conquête spatiale »
Authors: Gleize Georges-Emmanuel
Published: December 2024

D’une production volumineuse depuis les débuts de la « Conquête spatiale », la prospective spatiale fait l’objet d’un questionnement ancien dans l’écriture de l’histoire de l’espace (Burrows, Launius, Villain…). L’actualité militaire de cette prospective, qui croît à mesure de l’intérêt pour le contrôle de l’espace et de ses ressources, rend nécessaire l’actualisation de son étude. Le présent article ambitionne d’interroger cette prospective militaire spatiale, notamment lorsque celle-ci est écrite par les marges ( science fiction prototyping, design fiction ). Il s’agit ici de comprendre les formes, les acteurs, mais également les thèmes et les méthodes d’écriture de ces travaux qui mêlent science, géopolitique et science-fiction. La publication d’un certain nombre de sources en Europe comme aux États-Unis, en derniers lieux desquelles les trois volumes des travaux de la Red Team française permettent de saisir les particularités, mais également les limites de cet effort pour penser l’avenir de la guerre dans l’espace.