bluuebunny/crossref_metadata_2025 huggingface dataset:
Leaf character of sugar palm on various shades and concentrations of liquid organic fertilizer
Authors: Widarawati Rosi , Syarifah Risqa Naila Khusna , Prakoso Budi
Published: August 2023

Palm sugar has been developed to produce various products and raw materials for their derivatives. There is a very high morphological diversity of sugar palm plants, while the morphological identification of different sugar palm plant species in Banten province is still limited. The aim of this research is to determine the effect of different treatments, such as shade percentage, liquid organic fertilizer concentration, and a combination of both, on the properties of palm leaves. The experimental design used in this study was the 2-factor RCBD split plot with 3 levels each. The first factor is the variation of the shadow percentage, namely N0 (no shadow), N1 (55% shadow), and N2 (85% shadow). The second factor is different concentrations of liquid organic fertilizer (POC), namely P0 (0 ml/liter water), P1 (1 ml/liter water), and P2 (2 ml/liter water). The results showed that different types of shade yielded insignificant results in terms of variable number of leaves, total leaf area, and leaf greenness. The different types of liquid organic fertilizer concentration treatments and treatment combinations of shade percentage and liquid organic fertilizer concentrations did not influence any of the observed variables.Keywords: growth, organic fertilizer, palm, shade
THE POWER STRUCTURE OF UNDERGROUND ECONOMY ACTIVITIES AT ROMBENGAN MALAM KOTA MALANG: AN INSTITUTIONAL ECONOMIC PERSPECTIVE
Authors: Aprilianto Fitrian
Published: August 2023

One of Indonesia’s most common underground economy practices is the emergence of informal markets in the community. This study aimed to identify the pattern of the power structure of the Roma merchants in Malang City from an institutional economic perspective. In this study, the method used is a descriptive qualitative approach with a phenomenological type. This study uses primary data, data directly obtained from interviews and observations. The main informants in the study were traders, and the supporting informants were parking attendants. From the researchers’ findings, it was found that several realities of the power structure existed until now, among others, in the Roma merchant community, there was no hierarchical and formal pattern of power structures that officially governed the merchant community. Mastery in the Roma community was only informal.
PREJUDICE TOWARD PAPUAN STUDENTS: THE ROLE OF INTERGROUP ANXIETY, BELIEF, CONTACT QUANTITY, AND SOCIAL IDENTITY
Authors: Meliana Yenny , Tondok Marselius Sampe
Published: August 2023

This study examined the relationship between social identity and prejudice against ethnic Papuan students with intergroup anxiety as mediators and quantity of contact and belief as moderators. This study using a quantitative cross-sectional survey design. Respondents (n=452) were students in Surabaya selected using accidental sampling. Data were collected online using Google Forms by employed several scales that were RIVEC (Rejection, Intimacy, Values, Emotions, and Culture) prejudice scale, a-three factors social identity scale, intergroup anxiety scale, contact quantity scale, and belief scale. The results of hypothesis testing showed that intergroup anxiety significantly mediates the relationship between social identity and prejudice against ethnic Papuan students (β= -0.25; p<0.001). The results also revealed the moderator roles of belief (β = -0.13; p<0.05) and quantity of contact (β = 0.07; p<0.05) in predicting prejudice. This finding can be concluded that the emotions associated with low intergroup anxiety play a role in mediated high social identity with low prejudice scores. Increased contact with outgroups did not guarantee a decrease in prejudice scores in people with high social identities. Still, the involvement of cognitive processes through positive beliefs by individuals acts as a buffer effect so that people with high social identities can decrease prejudice scores.
Poverty Analysis of Cassava Farmers in Wonogiri Regency, Indonesia
Authors: Arbianti Arbianti , Rahayu Endang Siti , Sutrisno Joko
Published: August 2023

Poverty is a central issue in development programs in Indonesia. Most people still depend on agriculture for their livelihoods with relatively low productivity and business income, so poverty are common in rural areas. Most of the Wonogiri residents work in agriculture, where one of the superior products is cassava, the largest producer in Central Java. Poverty reduction in agriculture is a critical factor in reducing poverty in Indonesia. This study examined the poverty status and determinants affecting the poverty status of cassava farmers in Wonogiri Regency, Indonesia. Purposive sampling techniques were used in 120 cassava farmers in Wonogiri Regency. Primary data were obtained with the aid of well-structured questionnaires and interviews. The data were analyzed using Foster-Greer Thorbecke (FGT) index and logistic regression (logit). The result of Foster Greer-Thorbecke's (FGT) analysis showed that headcount index (P0) was 0,3417, poverty gap index (P1) was 0,2092, poverty severity index (P2) was 0,1280. The logistic regression (logit) showed that determinants of the poverty status of cassava farmers were education, land area, household size, and farming experience. There needs to be an increase in education, land area, farming experience, and reduce the number of family dependents with family planning government programs.
SWOT -AHP AS A METHOD OF PUBLIC SERVICE STRATEGY
Authors: Juharni Juharni , Bahri Syamsul , Mustafa Delly , Arhas Sitti Hardiyanti
Published: August 2023

SWOT-AHP helps companies to develop and plan strategic alternatives to overcome all the challenges faced. The purpose of this study is to determine the public service strategy of the Makassar Laboratory Center. This research is a quantitative research, using the SWOT-AHP approach to determine the right strategy in improving organizational performance. Data is collected from the documentation results and then analyzed according to SWOT-AHP stages.  The results of data processing show that in the item of strength, having an international standard TB lab is the most dominant strength possessed by BBLK Makassar, in the item of weakness, the biggest weakness is the organizational culture that still tends to be negative (rigid, individual, passive, lack of empathy in providing services, so efforts need to be made for the organization to carry out public services based on public excellent. While the most dominant opportunity to be utilized is information technology support, while the biggest threat faced by BBLK Makassar is the entry of foreign investors in laboratory services that have more sophisticated systems and equipment (the threat of global competition in the AFTA era). After the SWOT-AHP analysis, 4 strategies emerged, namely: increasing the promotion and technology-based information services, building an integrated information technology system, improving the quality and quantity of human resources, and maximizing tool utilization by adding new types of examinations.
La ciudad y las indias: Buenos Aires (1744-1820)
Authors: Sarmiento Jacqueline
Published: August 2023

Este libro aborda la presencia de las indias en la ciudad de Buenos Aires entre 1744 y 1820, enfatizando en sus formas de interacción social y de incorporación a la vida urbana. El objetivo principal es dar visibilidad a este grupo de indias urbanas y sus condiciones específicas de vida. En este sentido, el trabajo se centra en la observación y problematización de sus modos de actuación en la sociedad, en las formas de sujeción a las que estuvieron expuestas y en las estrategias que fueron capaces de implementar como respuesta a ellas. En este sentido, la propuesta es analizar a las indias a partir del cruce de diversas categorías identitarias y la definición de sus condiciones específicas; caracterizar su presencia en la ciudad, tanto en el espacio urbano en su conjunto, como en los grupos domésticos y en las instituciones.
Agreement of antimicrobial susceptibility testing of Pasteurella multocida and Mannheimia haemolytica isolates from preweaned dairy calves with bovine respiratory disease
Authors: Credille Brent C. , Capik Sarah F. , Credille Allison , Crossley Beate M. , Blanchard Pat , Woolums Amelia R. , Lehenbauer Terry W.
Published: August 2023

OBJECTIVE

Evaluate agreement among the antimicrobial susceptibility profiles of Mannheimia haemolytica or Pasteurella multocida obtained by transtracheal wash, nasal swab, nasopharyngeal swab, and bronchoalveolar lavage.

ANIMALS

100 Holstein and Holstein-cross bull calves with bovine respiratory disease.

METHODS

Calves > 30 days old with naturally occurring bovine respiratory disease were sampled sequentially by nasal swab, nasopharyngeal swab, transtracheal wash, and then bronchoalveolar lavage. Samples were cultured, and for each antimicrobial, the MIC of 50% and 90% of isolates was calculated, and isolates were categorized as susceptible or not. Categorical discrepancies were recorded. Percent positive agreement and kappa values were calculated between isolates for each of the sampling methods.

RESULTS

Antimicrobial susceptibility varied by pathogen and resistance to enrofloxacin, florfenicol, tilmicosin, and spectinomycin was detected. Minor discrepancies were seen in up to 29% of classifications, with enrofloxacin, penicillin, and florfenicol more frequently represented than other drugs. Very major and major discrepancies were seen when comparing florfenicol (1.9%) and tulathromycin (3.8 to 4.9%) across sampling methods. Some variability was seen in agreement for enrofloxacin for several comparisons (8.3 to 18.4%).

CLINICAL RELEVANCE

Susceptibility testing of isolates from 1 location of the respiratory tract can reliably represent susceptibility in other locations. Nevertheless, the potential for imperfect agreement between sampling methods does exist. The level of restraint available, the skill level of the person performing the sampling, the age and size of the animal, disease status, and treatment history all must be factored into which test is most appropriate for a given situation.
Entrepreneurial intention acknowledgment in sustainable entrepreneurship: An exploratory study
Authors: Dieguez Teresa , Sobral Thiago , Conceição Oscarina
Published: August 2023

Entrepreneurship is more than ever a key factor to successfully surviving and building a sustainable future, as it is linked to certain positive and proactive personality traits and innovation and creativity. Higher education plays an important role in this ongoing process, as students of today need to be guided into becoming tomorrow's leaders. The 21st century demands new skills and education. Regarding entrepreneurship, it will be more effective the better the associated profile with the student is understood in terms of entrepreneurial intention. This research involves 101 respondents from a population of 300 students. Taking as dimensions attitude, norms, and behaviour, hierarchical and k-means clustering methods were applied to the responses, yielding five entrepreneurial intention profiles (clusters). This is the main contribution of this study to the literature, which may help entrepreneurship program administrators and students alike to improve on their entrepreneurial skillset. This study also presents a new approach to better motivate and work with students on what concerns entrepreneurship. It can also be applied in all contexts and areas of knowledge.
UTICAJ ORGANIZACIONE PODRŠKE NA ORGANIZACIONU POSVEĆENOST
Authors: Tripković Jovana
Published: August 2023

U radu se vrši analiza uticaja organizacione podrške na organizacionu posvećenost. Cilj istraživanja jeste shvatanje značaja konstrukta organizacione podrške i načina na koji ovaj konstrukt utiče na organizacionu  posvećenost  zaposlenog.
MOGUĆNOSTI PRIMENE SOLARNE ENERGIJE U LIBIJI NA PRIMERU PROJEKTA U GRADU AZAVIJA
Authors: Ayad Mohamed
Published: August 2023

Libija se nalazi pred velikim izazovima još od 2011. godine, kako političkim, tako i bezbednosnim. Pored velikih poteškoća kroz koje je prolazio narod u ovo zemlji, Libija je pridala veliki značaj implementaciji solarne energije u fabrikama i domaćinstvima – pokuša­vajući da reši još jedan od problema, snabdevanje elektič­nom energijom. Klima u ovom zemlji značajno doprinosi stvaranju mogućnosti da solarna energija bude odličan izvor električne energije za veliki deo stanovništva. Cilj istraživanja u ovom radu je da utvrdi potencijal čiste sunčeve energije za proizvodnju električne energije u kompanijama i domaćinstvima u Libiji.
UTICAJ ZADOVOLJSTVA POSLOM NA UČINAK ZAPOSLENIH
Authors: Zayed Mohamed
Published: August 2023

U radu se analizira uticaj zadovoljstva poslom na učinak zaposlenih, na osnovu kojih se predlažu mere unapređenja.
UTICAJ KONFLIKTA NA ONBORDING PROCES
Authors: Momirović Biljana
Published: August 2023

Predmet istraživanja ovog master rada jesu konflikti koji se dešavaju u toku onbording pro­grama. Cilj ovog istražovanja jeste da indetifikujemo potencijalne konflikte koji se mogu desiti u toku onbor­ding procesa između novozaposlenog i ostatka kolektiva i da pronađemo adekvatne načine za predupređenje tih konflikata, kako ne bi došlo do neželjenih posledica po rad i poslovanje organizacije.
OGLAŠAVANJE U TRADICIONALNIM I NOVIM MEDIJIMA: SLIČNOSTI I RAZLIKE
Authors: Tošić Gordana
Published: August 2023

U radu se razmatra problematika oglašavanja u tradicionalnim i novim medijima, s posebnim osvrtom na sličnosti i razlike ovakvih vidova komunikacije s ciljanom javnošću. Rezultati sprovedenog istraživanja potvrdi su da tradicionalni mediji gube primat u procesu informisanja u odnosu na nove medije, da se sve manje pažnje obraća na oglasne poruke, kao i da reklame u obliku postova na društvenim mrežama privlače najveću pažnju medijskih korisnika.
Sentidos e significados da Educação Física para os alunos do Ensino Médio
Authors: Kawashima Larissa Beraldo
Published: August 2023

Este texto apresenta reflexões e experiências que foram socializadas no curso de extensão “Possibilidades e desafios da Educação Física no Ensino Médio”, realizado pelo Curso de Licenciatura e Bacharelado de Educação Física da Universidade Estadual de Roraima (UERR), em novembro de 2021. O texto está dividido em duas partes: a apresentação dos conceitos sobre sentido e significado e sua relação com as aulas de Educação Física no Ensino Médio; as experiências pedagógicas no campus São Vicente. Para compreensão do sentido e significado da Educação Física para os estudantes do Ensino Médio, é importante conhecermos seu conceito, que neste caso recorro aos propostos por Bernard Charlot sobre a relação com o saber. As experiências relatadas neste texto se referem aos 1º, 2º e 3º anos, sendo uma com o teatro de nutrição (interdisciplinar), uma com as danças e outra sobre a educação para o lazer e o kart. A mudança de significado do conceito de Educação Física emitido pela sociedade só será possível se houver uma mudança de sentido para os alunos durante as aulas na escola, ou seja, é preciso modificar o sentido para o sujeito, pois as relações profícuas que estabelecerem com os saberes disponíveis durante as aulas, garantirão a legitimação de um novo significado para a Educação Física, que é social.
Metástasis: La Célula Invasiva
Authors: Olascoaga Caso Eugenia Marina , Juárez Aguilar Enrique
Published: August 2023

Mientras que la célula de cáncer se caracteriza por su proliferación exacerbada que da lugar al crecimiento de un tumor, es su capacidad de invadir nuevos y distantes órganos la causante de la muerte del organismo. Esta capacidad invasiva, conocida como metástasis, es regulada por moléculas solubles provenientes de células cercanas al tumor o a través de la circulación sanguínea, tales como hormonas y factores de crecimiento.
Aterosclerosis: nuevos tratamientos/ compuestos tradicionales
Authors: López Franco Oscar
Published: August 2023

En la actualidad, una de las enfermedades crónicas-degenerativas más frecuentes es la aterosclerosis, donde su alta incidencia, el costo económico asociado (sanitario y laboral) y la falta de tratamientos efectivos, nos lleva a la búsqueda de nuevos tratamientos. Una forma de abordar esta búsqueda es mediante modelos animales, que posteriormente se pueda extrapolar a los humanos. De este modo, ratones mutados genéticamente, como es el caso de los ratones deficientes en Lipoproteína E (Apo E-/-), los cuales NO expresan dicha Lipoproteína, generan expontáneamente placa de ateroma, originando Aterosclerosis.
Considerando el importante componente inflamatorio asociado a la aterosclerosis, abordamos un posible tratamiento con un compuesto (Partenolide) capaz de inhibir una de las principales rutas inflamatorias a nivel celular (activación del NF-κB). El partenolide es una lactona procedente de extractos de las hojas del Tanacetum parthenium o matricaria, utilizado frecuentemente en la medicina tradicional.
Diseño y validez de un cuestionario sobre aplicación de Principios Bioéticos
Authors: Santés Bastián María del Carmen , Preciado Serrano María de Lourdes , Colunga Rodriguez Cecilia , Del Ángel Salazar Erika Mayte , Fernández Sánchez Higinio
Published: August 2023

Introducción: La aplicación de los principios bioéticos en los profesionales de Enfermería es fundamental para brindar cuidados oportunos a los pacientes. Objetivo: Diseñar y validar un cuestionario sobre aplicación de principios bioéticos para el personal de Enfermería de un hospital de segundo nivel de atención. Métodos: Estudio en dos fases. Primera: se diseñaron enunciados respecto a los principios bioéticos de autonomía, beneficencia y justicia, que se sometieron a la validez de contenido con la técnica de juicio de expertos. Segunda: se efectuó la validez del constructo mediante el análisis de los índices de dificultad, discriminación, variabilidad y validez del ítem, así como la validez y fiabilidad del cuestionario total, con la participación de 214 enfermeros. Resultados: Se diseñaron 53 ítems y el análisis de los expertos consideró 42 como adecuados; los coe- ficientes de validez de constructo (.74) y fiabilidad Alpha de Cronbach (.80) se consideraron también adecuados. Conclusiones: Se ofrece un cuestionario factible y breve para identificar la aplicación de principios bioéticos en el personal de Enfermería, y así garantizar el óptimo cuidado de los pacientes hospitalizados.
Design and psychometric validation of a questionnaire on the application of Bioethical Principles
Abstract
Introduction: The application of bioethical principles in nursing professionals is essential when providing quality nursing care. Objective: To design and validate a questionnaire about the application of the bioethical principles in hospital nursing staff. Methods: A two-fold study. First, questions were designed regarding the bioethical principles of autonomy, beneficence and justice. These were subjected to: content validity with an expert panel. Secondly, a construct validity was performed through the statistical analysis of the difficulty, discrimination, variability and validity index, in a sample of 214 hospital nurses. Results: Fifty-three items were design and the expert panel considered 42 items as adequate. In the construct validity, the coefficient (.74) and reliability Cronbach’s Alpha (.80) were also considered adequate. Conclusions: We offer a reliable and short survey to identify the application of the bioethical principals in hospital nursing staff to ensure quality care for hospitalized patients.
La mSalud como una herramienta para la salud
Authors: Rodríguez Montes Oscar Eduardo , Gogeascoechea Trejo María del Carmen
Published: August 2023

La salud móvil (mSalud) constituye uno de los términos más buscados en la actualidad en el área de las ciencias de la salud; sin embargo, su definición como herramienta tecnológica interdisciplinaria podría confundirse entre los conceptos de salud electrónica (eSalud), que es en donde que se origina, o de la salud ubicua (uSalud), que utiliza elementos tecnológicos más complejos para lograr la mo- nitorización a través de sensores y dispositivos.
El presente artículo pretende clarificar el concepto y los antecedentes del término mSalud, así como las principa- les funciones y utilidades que ha originado en los últimos años.
Octopus Protest
Authors: Burns Leah
Published: August 2023

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Sprawl Signage
Authors: Wilkes James
Published: August 2023

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Is This What an Environmentalist Looks Like?
Authors: Bose Pablo
Published: August 2023

Somewhere on the streets of Seattle, on a brightwinters day in 1999, someone called me an environmentalist. I still haven’t quite recovered from the shock.
Lawn Snakes
Authors: Sau Wai Tai
Published: August 2023

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Untitled
Authors: Carranza Leonarda
Published: August 2023

One thing that we all agree on, is that it was dark when we left El Salvador. Some think it was night, evening, or just before day break. But all those that have a memory of that day in May remember that it was dark.
Combination of Herbal Steam Bath and Endorphin Massage to Increasing Breast Milk Production
Authors: Rhomadona Shinta Wurdiana , Primihastuti Dianita
Published: August 2023

The importance of breastfeeding has strong evidence. Complementary therapy that can increase milk production is to increase comfort and body fitness by using herbal steam baths. This is local wisdom that is still preserved in Indonesia as a therapy for postpartum mothers with water vapor. Another similar alternative is endorphin massage, which is a light touch therapy on the neck, back and arms that can trigger the release of endorphins that affect milk production. The purpose of this study was to estimate that the combination of the two methods would be more effective in influencing breast milk production. This research design is a quasi-experimental. The population in this study were postpartum mothers at the Independent Practice Midwife in Surabaya with a total sample of 40 which were divided into treatment and control groups, using purposive sampling technique. The treatment group was given intervention with a combination of herbal steam baths 2x/week for 5-20 minutes and endorphin massage 2x/week for 20 minutes, while the control group was not given. Each group was given a pre-test and post-test to determine the volume of breast milk production with indicators of increased baby weight, increased frequency of urination and defecation. Statistical test using Mann Whitney and Shapiro Wilk. The results showed that there was a significant effect of the combination of herbal steam baths and endorphin massage on increasing breast milk production with a value of α =0,000 atau α <0,05. There was a significant difference in milk production in the treatment group compared to the control group with a value of α =0,000 atau α <0,05. Conclusion: By doing a combination of herbal steam baths and endorphin massage regularly, it can increase milk production.
Description of Level Education and Employment of Nagari Gurun Panjang Induk Community, Bayang District, Pesisir Selatan District
Authors: Yulizawati Yulizawati , Afritunando Yogi
Published: August 2023

Population development without being balanced with controls to measure the desired population will only cause social, economic problems with all the high population growth from year to year requiring investment and facilities in the fields of education, health, employment, housing, and so on. This of course will be a quite complicated problem for the government in building and improving the standard of living for the country. Methods this research is study eksploratif with primary and secondary data. Populasi is citizen at nagari gurun panjang induk community. The sample is total sampling. The highest percentage of community work is housewives 23.5%. Te percentage of education in the community is high school 38.6%. In a simple sense, education is a human effort to develop his personality in accordance with the values in society and culture. The level of community education can affect the level of employment, this is evidenced by the percentage of housewives who do not work which is higher than other jobs, while at the level of education, the average community only has education up to high school level
Ultrasound Diagnosis of Congenital Diaphragm Hernia And Successful Outcome After Postnatal Surgery
Authors: Yusrawati Yusrawati , Faisal Putri Mentari
Published: August 2023

Background: Congenital diaphragmatic hernia (CDH) is a disorder where abdominal contents protrude into the chest. Congenital diaphragmatic hernias are seen in 1 of every 2000-4000 live births. Mortality is predominantly due to the development of pulmonary hypoplasia which is thought to be due to the mass effect on the developing lung.Case Report:Mrs. Y, a 32-year-old controlled for antenatal care at the fetomaternal polyclinic M Djamil hospital. She had no complaints, the patient was referred from another hospital with a suspected fetal diaphragm hernia. The patient is known to be 38-39 weeks term pregnancy, from ultrasound examination found herniation of abdominal contents into the thoracic cavity and. the liquor was excessive and the doppler study was normal. The ultrasound showed normal growth and corresponded to 38 week Then the patient was planned for caesarean section and a hernia repair surgery. The neonate was admitted to the neonatal intensive care unit (NICU). He was shifted to the pediatric surgeon with ventilator support after 48 h and was undergoing surgery. There was a posterolateral left sided defect (BOCKDALEK type) of around 22–24 mm. The intestines were reduced to the abdomen and the closure was done. Immediately after the surgery, the child was admitted back to the NICU and the further postnatal course was uneventful.Discussion and Conclusion: CDH is a malformation of the diaphragm due to failure of closure of the pleuroperitoneal canal at around 10 weeks leading to herniation of abdominal contents into the thoracic cavity leading to compression of lung tissues at pseudo glandular stage. CDH is often ultrasound diagnosed before birth [120, 121]. The intestine and/or the liver may be in the thorax and the lungs are small. US scan allows detailed assessment of the heart. The survival depends on the contralateral lung volume, Ninety percent of cases are due to posterolateral defect which is also called Bochdalek hernia—80% are left sided, 15% are right sided and 5% are bilateral. Herniated viscera leads to pulmonary hypoplasia and pulmonary hypertension. Prognosis depends on the gestational age at diagnosis (earlier the diagnosis, likely larger the defect), associated anomalies, contralateral lung volume, pulmonary vasculature (Doppler), cardiac function, liver herniation and gestational age at delivery
Using additive regression models for short-term forecasting of financial macro-indicators and assessing the potential for financing megaprojects
Authors: Kuznetsov Nikolay
Published: August 2023

The subject of this article is the issue of using additive regression models to predict financial indicators at the macro level. At the same time, special attention is paid to the impact of the economy monetization on the possibility of attracting funding for global development projects (megaprojects). It is shown that the main drawback of the most common forecasting models today is their situation-dependent nature. This, in turn, creates difficulties with the initial setup of the models and the subsequent interpretation of the results obtained, limiting the scope of the models, making the use of this toolkit difficult for financial professionals who do not have special mathematical training. With the help of modeling, forecast values of the gross domestic product (GDP) and money supply (M2) for the short-term time obtained, on the basis of which the expected value of the level of the economy monetization was calculated. Based on a predictive assessment of the level of monetization, it is shown that at the moment the country has a limited potential for increasing domestic debt, which, in the conditions of closing access to international capital markets and partial blocking of state reserves, can become a factor in disrupting the financing of megaprojects for the economy structural modernization. Directions for improving the monetary policy aimed at correcting this situation and increasing domestic investment activity are proposed.
Functionality and quality of life of patients with knee osteoarthritis after platelet-rich therapy
Authors: Riedo Cristiane de Oliveira , Souza Makcilene Paranho de , Salvarani Wagner , Gavioli Aroldo , Evangelista Fernanda Ferreira , Oliveira Nelson Luiz Batista de , Pelloso Sandra Marisa , Bitencourt Mariá Ramanio , Egger Paulo Acácio , Carvalho Maria Dalva de Barros
Published: August 2023

Objective: To evaluate the functional capacity and quality of life of patients with knee osteoarthritis submitted to platelet-rich plasma injection. Methods: Observational cross-sectional study carried out with 31 subjects seen at the orthopedics outpatient clinic of a university hospital in a municipality in northwestern Paraná, from 2016 to 2017. For data collection, a sociodemographic questionnaire was used, the Short Form36 and Lequesne's Algofunctional Questionnaire. For data analysis, descriptive statistics were used, with measures of dispersion, interquartile range and non-parametric Wilcoxon test. A 95% confidence level was established, and associations with p < 0.05 were considered statistically significant. All analyzes were performed using the R statistical environment.  Results: Most patients were female, with a mean age of 59.8 years (SD ± 12.2). In the pre-intervention with platelet-rich plasma, all subjects were classified in the extremely severe category. There was a significant improvement in all eight Short Form-36 domains, as well as pain reduction and functional recovery in the 31 patients. Conclusion: Platelet-rich therapy through injection in patients with knee osteoarthritis improved quality of life and reduced pain with increased operational capacity.
Uso de substâncias psicoativas por estudantes de enfermagem durante a pandemia da COVID-19
Authors: Romero Betina Kromann , Caldeira Lucas de Oliveira , Weizemann Luana Patricia , Zanella Renata , Campos Terezinha Aparecida , Oliveira Mateus Schmitz Ramalho de , Correia Ryan Mayk Caetano , Rocha Claudia Aparecida Godoy , Benjamini Luiz Felipe Pohlenz , Cheffer Maycon Hoffmann
Published: August 2023

Objetivo: Analisar o aumento ou diminuição de psicotrópicos utilizados por acadêmicos durante a pandemia da COVID-19. Métodos: Estudo descritivo, retrospectivo, de abordagem quantitativa, com acadêmicos de enfermagem matriculados no 5º e 7º período no ano de 2021 de um Centro Universitário privado do Oeste do Paraná. A coleta de dados foi feita por meio de questionário virtual (Google Forms) e os dados obtidos foram ordenados e analisados por meio da estatística descritiva simples. Resultados: Participaram da pesquisa 74 acadêmicos, dentre os quais: 25,7% foram infectados pelo novo coronavírus; 48,6% avaliaram sua saúde mental como excelente e boa. Houve incremento no nível alto de consumo de 2,7% no consumo de álcool e tabaco, 17,5% de açúcar, 9,5% de cafeína, 8,2% de ansiolíticos, 5,4% de antidepressivos e de indutores do sono. O consumo de cocaína era zero e aumentou para nível baixo, 1,8% dos participantes começaram a consumir cannabis durante o isolamento social. Conclusão: O aumento no consumo de psicoativos revela a necessidade de uma maior avaliação dos efeitos do seu uso durante e pós isolamento social.
Identification of Reservoir Distribution Using Extended Elastic Impedance (EEI) Inversion in the "Z" Field of the Kutai Basin
Authors: Haq Zikra Miftahul , Komara Eki , Lestari Wien
Published: August 2023

This research was conducted using EEI inversion on seismic data in Z Field, Kutai Basin. The EEI inversion is effectively used to determine the reservoir distribution by eliminating the angle limit on the elastic impedance to the Chi angle so that it can be correlated with petrophysical parameters that are sensitive to lithology and fluids. The data used in this study are well data, checkshots, horizons, and partial-stack angle gather 3D seismic data. The data obtained is processed to obtain the target zone first based on log interpretation. Based on data processing, the target zone is obtained at 1513 m to 1531 m. Sensitivity analysis was conducted to determine the sensitive parameters, which can separate the lithology of the formation. In the sensitivity analysis, the most sensitive log to separate lithology is the Vp/VS log, which can separate sandstone, shale, and coal. Furthermore, the EEI inversion analysis was carried out to obtain the most suiTable model for the inversion, the Based Hard Constraint model was obtained with a correlation reaching 0.997 and an error value of 0.078. Based on the EEI inversion, the target zone in the Z-field at a depth of 1258 ms - 1269 ms with a sandstone reservoir in the EEI range of 6000 (m/s)(g/cc) - 7500 (m/s)(g/cc) which spreads from northeast to south. The distribution of the sandstone reservoir is surrounded by coal with a range of EEI 7500 (m/s)(g/cc) - 12000 (m/s)(g/cc), and also the distribution of shale in the EEI range of 7500(m/s)( g/cc) - 9200(m/s)(g/cc).
Morphological Analysis of Anak Krakatau Volcano after 22 December 2018 Eruption using Differential Interferometry Synthetic Aperture Radar (DInSAR)
Authors: Iqbal Mochamad , Denhi Anjar Dwi Asterina , Kristianto  , Prayoga Ardy
Published: August 2023

Anak Krakatau Volcano is an active volcano located in the Krakatau Complex, Sunda Strait, Indonesia. On 22 December 2018, the volcano experienced a major eruption that led to a tsunami that devastated the shores of the islands of Java and Sumatra and killed up to 437 people. The eruption also destroyed the volcano’s body and change its shape drastically and forming a large crater in the southwestern part. After that eruption, the volcano continues to grow up. This research aims to analyze the deformation of the Anak Krakatau Volcano post-2018 eruption by using the differential interferometry SAR method (DInSAR). In order to support the analysis, we additionally compare the DInSAR result with tectonic-volcanic activity. Sentinel 1-A type SLC satellite imagery data from 5 June 2019 to 7 January 2020; consisting of 19 images or 18 pairs as master and slave were used to producing a deformation map. DInSAR result shows the volcano was generally experiencing deflation during the period, ranging from -1.03 to -4.81 cm (-3.01 cm average). However, inflation also occurred ranging from 0 to 5.99 cm, correlating with shallow and deep volcanic activity and followed by eruptions in October 2019 when the highest activities were observed. Furthermore, coherence value should be highly considered along with DInSAR processing, and this research allows that coherence to be acceptable.
For the Sake of Making Molecules
Authors: Togni Antonio
Published: August 2023

The aim of this article, while reviewing part of my research activities, is to illustrate the somewhat chaotic way leading from one specific topic to another – from e.g. ferrocenyl ligands for asymmetric catalysis, to asymmetric fluorination, to reagents for perfluoroalkylation, just to mention some of the most fruitful ones. That the way meandering  through several areas of research in chemical synthesis can be described as chaotic is not primarily due to my inability to plan the work of my research group. In the contrary, it is argued that academic research, viewed as mean to educating and forming young researchers, should resist the temptation towards an increasing projectification, milestone mentality, the myth of societal relevance, and consciously aim for a more anarchical trait, much in the sense of Feyerabend’s “anything goes”.
Details Matter in Structure-based Drug Design
Authors: Kuhn Bernd , Peters Jens-Uwe , Rudolph Markus G. , Mohr Peter , Stahl Martin , Tosstorff Andreas
Published: August 2023

Successful structure-based drug design (SBDD) requires the optimization of interactions with the target protein and the minimization of ligand strain. Both factors are often modulated by small changes in the chemical structure which can lead to profound changes in the preferred conformation and interaction preferences of the ligand. We draw from examples of a Roche project targeting phosphodiesterase 10 to highlight that details matter in SBDD. Data mining in crystal structure databases can help to identify these sometimes subtle effects, but it is also a great resource to learn about molecular recognition in general and can be used as part of molecular design tools. We illustrate the use of the Cambridge Structural Database for identifying preferred structural motifs for intramolecular hydrogen bonding and of the Protein Data Bank for deriving propensities for protein-ligand interactions.
Anti-UV the Hippo Way
Authors: Housecroft Catherine E.
Published: August 2023

The hippopotamus secretes a liquid from its skin that may act both as a sunscreen and an antibiotic.
Dealing with induced fit, conformational selection and secondary poses in molecular dynamics simulations for reliable free energy predictions
Authors: Procacci Piero
Published: August 2023

In this study we have tested the performance of standard molecular dynamics simulations (MD), replicates of shorter standard MD simulations, and Hamiltonian Replica Exchange (HREM) simulations for the sampling of two macrocyclic hosts for guests delivery, characterized by induced fit (phenyl-based host) and conformation selection (naphtyl-based host), and of the ODR-BRD4(I) drug-receptor system where the ODR ligand can assume two main poses. For the optimization of the HREM simulation, we have proposed an on-the-fly iterative scheme for equalizing the acceptance ratio along the replica progression at constant replica number. We have found that while short MD replicates are able to sample as effectively as HREM the diverse conformational states in the phenyl-based host and in the ODR-BRD4(I) complex, in the naphtyl-based macrocycle, characterized by long-lived meta-stable states, HREM is the only viable alternative for a reliable canonical sampling of the rugged conformational landscape. Implications of these results for free energy calculation of binding free energy in drug-receptor systems are highlighted.
Elucidating the Influence of Electrolyte Additives on Iron Electroplating Performance Towards Application in Iron-Based Batteries
Authors: Gimenez-Garcia Inmaculada , Forner-Cuenca Antoni
Published: August 2023

All-iron redox flow batteries are a promising alternative for grid-scale energy storage; however, their efficiency and lifetime are hampered by the poorly understood plating process, the limited reversibility of the negative half-cell, and the presence of competitive reactions. In this work, we propose a methodology to deconvolute the nucleation parameters of iron via a suite of electrochemical techniques, spectroscopy, and analytical models, coupled with microscopic and crystallographic techniques. We perform a systematic analysis with iron-based electrolytes to deconvolute the simultaneous plating and hydrogen evolution reactions, and investigate an array of additives to tune electroplating descriptors. We find that all additives studied are able to regulate the plating process and find that highly stable iron-complexes based on buffers, such as iron-borates or -citrates deliver greater battery performance in symmetric configuration, with nearly 50% higher cyclability than the baseline electrolyte. These additives show superior selectivity, with improvements in faradaic efficiencies from 60% to ~90% due to the balanced effects of enhanced nucleation and side reaction suppression. Herewith, the aim of this study is to bridge the knowledge gap between the role of additives, kinetics and efficiency of the electrodeposition reaction, and their interplay defining battery cycling performance.
QMrebind: Incorporating quantum mechanical force field reparameterization at the ligand binding site for improved drug-target kinetics through milestoning simulations
Authors: Ojha Anupam Anand , Votapka Lane , Amaro Rommie
Published: August 2023

Understanding the interaction of ligands with biomolecules is an integral component of drug discovery and development. Challenges for computing thermodynamic and kinetic quantities for pharmaceutically relevant receptor-ligand complexes include the size and flexibility of the ligands, large-scale conformational rearrangements of the receptor, accurate force field parameters, simulation efficiency, and sufficient sampling associated with rare events. Our recently developed multiscale milestoning simulation approach, SEEKR2 (Simulation Enabled Estimation of Kinetic Rates v.2), has demonstrated success in predicting binding (kon) and unbinding (koff) kinetics by employing molecular dynamics (MD) simulations in regions closer to the binding site and Brownian dynamics (BD) simulations far from the binding site. The MD region is further subdivided into smaller Voronoi tessellations to improve the simulation efficiency and parallelization. To date, all MD simulations are run using general molecular mechanics (MM) force fields. The accuracy of calculations can be further improved by incorporating quantum mechanical (QM) methods into generating system-specific force fields through reparameterizing ligand charges in the bound state. The force field reparametrization process modifies the potential energy landscape of the bimolecular complex, enabling a more accurate representation of the intermolecular interactions and polarization effects at the bound state. We present QMrebind (Quantum Mechanical force field reparameterization at the receptor-ligand binding site), an ORCA-based software that facilitates reparameterizing the potential energy function within the phase space representing the bound state in a receptor-ligand complex. With existing data from our SEEKR2 estimates and experimentally determined kinetic rates, we compare and interpret the receptor-ligand unbinding kinetics obtained using the newly reparameterized force fields for model host-guest systems and HSP90-inhibitor complexes. This method provides an opportunity to achieve higher accuracy in predicting kon and koff.
Chemically reversible CO2 uptake by dendrimer-impregnated metal-organic frameworks
Authors: Goncalves Rebecca , Cuadrado Carlos , Malliakas Christos , Wang Zhiwei , Thommes Matthias , Snurr Randall , Hupp Joseph
Published: August 2023

Industrialization over the past two centuries has resulted in a continuous rise of global CO2 emissions. These emissions are changing ecosystems and livelihoods. Therefore, methods are needed to capture these emissions from point sources and possibly from our atmosphere. Though the amount of CO2 is rising, it is challenging to capture directly from air because its concentration in air is extremely low, 0.04%. In this study, amines installed inside metal-organic frameworks (MOFs) are investigated for adsorption of CO2, including at low concentrations. The amines used are polyamidoamine dendrimers that contain many primary amines. Chemically reversible adsorption of CO2 via carbamate formation was observed, as was enhanced uptake of carbon dioxide via physisorption. Limiting factors in this initial study are comparatively low dendrimer loadings and slow kinetics for carbon dioxide uptake and release, even at 80 ˚C.
Generative BigSMILES: An Extension for Polymer Informatics, Computer Simulations & ML/AI
Authors: Schneider Ludwig , Walsh Dylan , Olsen Bradley , de Pablo Juan
Published: August 2023

The BigSMILES notation, a concise tool for polymer ensemble representation, is augmented here by introducing an enhanced version called generative BigSMILES. G-BigSMILES is designed for generative workflows, and is complemented by tailored software tools for ease of use. This extension integrates additional data, including reactivity ratios (or connection probabilities among repeat units), molecular weight distributions, and ensemble size. An algorithm, interpretable as a generative graph is devised that utilizes these data, enabling molecule generation from defined polymer ensembles. Consequently, the G-BigSMILES notation allows for efficient specification of complex molecular ensembles via a streamlined line notation, thereby providing a foundational tool for automated polymeric materials design. In addition, the graph interpretation of the G-BigSMILES notation sets the stage for robust machine learning methods capable of encapsulating intricate polymeric ensembles. The combination of G-BigSMILES with advanced machine learning techniques will facilitate straightforward property determination and in-silico polymeric material synthesis automation. This integration has the potential to significantly accelerate materials design processes and advance the field of polymer science.
“The Forbidden Kingdom”: Dari Representasi sampai Dependensi Kajian Orientalisme Edward Said
Authors: Badri Badri , Ihsanullah Abi , Heriyanti Lilis
Published: August 2023

The objectives of this research are to describe the representation and the dependency of the East and West using Edward Said's Orientalism. This research uses a descriptive qualitative method. The data collection method uses library research. The researcher watched The Forbidden Kingdom movie, then read books and journals that related to the topic. Data analysis was carried out by descriptive analysis between the data obtained and the explanation of the theory. The findings are the author represents the East through Lu Yan, The Silent Monk, Warlord, and Monkey King. Lu Yan represents a lazy and irrational person, The Silent Monk represents a harbored suspicion person, Warlord represents a depravity and inhuman person, and Monkey King represents a foolish person. The author also represents the East through the forests which have high grass and the deserts which have extreme weather. These places are dangerous and not friendly. The author also represents the East through citizens who are irrational and love violence. The author describes dependency on East to West, through China to Jason, while Jason is pulled by the golden staff to China in order to make China peaceful. AbstrakTujuan dari penelitian ini adalah untuk menggambarkan representasi serta ketergantungan Timur dan Barat menggunakan teori orientalisme milik Edward Said. Penelitian ini menggunakan metode kualitatif deskriptif. Metode pengumpulan data menggunakan studi pustaka. Peneliti menonton film The Forbidden Kingdom kemudian melakukan pembacaan terhadap buku dan jurnal terkait dengan topik yang akan diteliti. Analisis data dilakukan dengan cara analisis deskriptif antara data-data yang diperoleh dengan penjelasan teori. Hasil dari penelitian ini yaitu pengarang merepresentasikan Timur melalui tokoh Lu Yan, Biksu Pendiam, Warlord, dan Raja Monyet. Lu Yan digambarkan sebagai sosok yang pemalas dan irasional, Biksu Pendiam digambarkan sebagai sosok yang memendam rasa curiga, Warlord digambarkan sebagai sosok yang bejat moral dan tidak manusiawi, serta Raja Kera digambarkan sebagai sosok yang bodoh. Pengarang juga merepresentasikan Timur melalui hutan yang mempunyai rerumputan tinggi dan padang pasir yang bercuaca ekstrim. Dua tempat ini berbahaya dan tidak bersahabat. Pengarang juga merepresentasikan Timur melalui kehidupan sosial warga yang irasional dan mendahulukan kekerasan. Pengarang merepresentasikan ketergantungan Timur terhadap Barat melalui China terhadap Jason yang diawali dengan ditariknya Jason oleh tongkat emas menuju China untuk membuat China damai kembali.