bluuebunny/crossref_metadata_2025 huggingface dataset:
Influences of altering footstrike pattern and cadence on lower extremity joint coordination and variability among runners with patellofemoral pain
Authors: Liu Yue , Qi Yujie , Song Yanliqing , Feng Li , Wang Lin
Published: January 2023

Background

Patellofemoral pain (PFP) is a common overuse injury among runners. It is not only a hindrance to the runner’s training, but also to the runner’s quality of life. PFP runners may strategize different running strategies to reduce patellofemoral joint stress, release pain, and improve function.

Purpose

This study aimed to determine the changes in joint coordination and variability under combinations of foot strike pattern and cadence for runners with patellofemoral pain.

Methods

Twenty male runners with PFP performed six running strategies which were two strike patterns named forefoot (FFS) and rearfoot (RFS) accompanied by three running cadences named slow10%, normal, and fast10%. A modified vector coding technique and circular statistics were respectively used to identify the coordination pattern and variability between hip sagittal-knee frontal (HsKf), hip sagittal-knee sagittal (HsKs) and knee transverse-ankle frontal (KtAf) during stance phase. Coordination patterns which were conformed with anatomical motion pattern was classified as mechanically sound, and the distribution frequency of each coordination pattern was quantified.

Results

Switching to FFS, the HsKf couples (p < 0.001, ES = 1.34) and the HsKs couples (p = 0.001, ES = 0.82) displayed significantly greater frequency in mechanically unsound coordination pattern during the initial stance phase. The effect of increasing running cadence on RFS displayed significantly greater frequency in mechanically unsound hip dominancy (p = 0.042, ES = 0.65) and knee dominancy (p = 0.05, ES = 0.70) coordination patterns for HsKf couples as well as for HsKs couples (p = 0.023, ES = 0.86) during the initial stance phase. Combined with FFS and fast10% cadence, HsKs couples showed more hip-dominated mechanical sound coordination pattern (p = 0.002, ES = 1.25). Further, altering footstrike pattern and cadence failed to change the coordination variability.

Conclusions

Changing running cadence (± 10%) combined with transfer strike pattern from RFS to FFS could not increase the distribution frequency in mechanically sound coordination patterns and change coordination variability for PFP runners.
Utility of a buccal swab point-of-care test for the IFNL4 genotype in the era of direct acting antivirals for hepatitis C virus
Authors: Sy Aminata , McCabe Leanne , Hudson Emma , Ansari Azim M. , Pedergnana Vincent , Lin Shang-Kuan , Santana S. , Fiorino Marzia , Ala Aftab , Stone Ben , Smith M. , Nelson Mark , Barclay Stephen T. , McPherson Stuart , Ryder Stephen D. , Collier Jane , Barnes Eleanor , Walker Ann Sarah , Pett Sarah L. , Cooke Graham ,   on behalf of the STOP-HCV-1 trial team
Published: January 2023

Background

The CC genotype of the IFNL4 gene is known to be associated with increased Hepatitis C (HCV) cure rates with interferon-based therapy and may contribute to cure with direct acting antivirals. The Genedrive® IFNL4 is a CE marked Point of Care (PoC) molecular diagnostic test, designed for in vitro diagnostic use to provide rapid, real-time detection of IFNL4 genotype status for SNP rs12979860.

Methods

120 Participants were consented to a substudy comparing IFNL4 genotyping results from a buccal swab analysed on the Genedrive® platform with results generated using the Affymetix UK Biobank array considered to be the gold standard.

Results

Buccal swabs were taken from 120 participants for PoC IFNL4 testing and a whole blood sample for genetic sequencing. Whole blood genotyping vs. buccal swab PoC testing identified 40 (33%), 65 (54%), and 15 (13%) had CC, CT and TT IFNL4 genotype respectively. The Buccal swab PoC identified 38 (32%) CC, 64 (53%) CT and 18 (15%) TT IFNL4 genotype respectively. The sensitivity and specificity of the buccal swab test to detect CC vs non-CC was 90% (95% CI 76–97%) and 98% (95% CI 91–100%) respectively.

Conclusions

The buccal swab test was better at correctly identifying non-CC genotypes than CC genotypes. The high specificity of the Genedrive® assay prevents CT/TT genotypes being mistaken for CC, and could avoid patients being identified as potentially ‘good responders’ to interferon-based therapy.
The effect of contraceptive access reform on privately insured patients: Evidence from Delaware Contraceptive Access Now
Authors: Yoder Maranna , Boudreaux Michel
Published: January 2023

Background

Many states are implementing comprehensive programs aimed at reducing persistent barriers to contraceptive care. Evidence on the effectiveness of these programs is essential for practice improvement and policy development.

Objective

To evaluate changes in the probability of initiating a contraceptive method by women with employer sponsored insurance after implementation of Delaware Contraceptive Access Now (DelCAN), a statewide initiative that aimed to increase access to long-acting reversible contraceptives (LARCs).

Design, setting, and participants

We used a difference-in-differences design to examine contraceptive initiation rates. Data came from IBM Marketscan and covered women age 15–44 enrolled in employer sponsored insurance. The primary outcome was insertion of a LARC, both in the overall study population and in the immediate postpartum (IPP) setting. Secondary analysis examined changes to other contraceptive method types.

Results

The cohort of 4,550,459 enrollees generated a sample of 11,888,837 person-years and 615,670 childbirth hospitalizations. Difference-in-differences estimates suggested that DelCAN was associated with a 0.3 percentage point (95% CI [0.2, 0.5], p<0.001) increase in the LARC insertion rate in the overall study population and a 0.4 percentage point increase (95% CI [0.2, 0.6], p<0.001) in the percent of births adopting IPP LARC. Associations between DelCAN and LARC insertion appeared stronger for adolescents compared to older women. Results for other method types were less consistent.

Conclusions

A comprehensive statewide program was associated with increased LARC insertion rates among enrollees with employer sponsored insurance. Understanding the effect of these programs is critical for on-going policy development for states engaged in contraceptive access reform.
Adhesives free bark panels: An alternative application for a waste material
Authors: Wenig Charlett , Reppe Friedrich , Horbelt Nils , Spener Jaromir , Berendt Ferréol , Cremer Tobias , Frey Marion , Burgert Ingo , Eder Michaela
Published: January 2023

The proportion of bark in tree trunks is in the range of ~ 10–20%. This large amount of material is currently mainly considered as a by- or even waste-product by the timber processing industry. Recently, efforts towards the use of bark have been made, e.g. as a raw material to harvest different chemical compounds or as an additive for wood particle boards. Our motivation for this work was to keep the bark in an almost natural state and explore alternative processes and applications for use. The traditional method of de-barking tree trunks by peeling was used to harvest large bark pieces. Two pieces of peeled bark were placed crosswise, with the rhytidom side (outer bark) facing each other. After different conditioning steps, bark pieces were hot pressed to panels without adding adhesives. These experiments on bark samples of different Central European tree species suggest that production of panels with species dependent properties is possible and feasible. This is a step towards producing sustainable panels by using a natural waste material, while retaining its beneficial structure and its natural chemical composition.
Participation and adherence to mammography screening in the Capital Region of Denmark: The importance of age over time
Authors: Pett Lindsay , Hollenberg Becky , Mahoney Jessica , Paz Jake , Siu Nathan , Sun Amanda , Zhang Rachel , von Euler-Chelpin My
Published: January 2023

Mammography screening’s effectiveness depends on high participation levels. Understanding adherence patterns over time is important for more accurately predicting future effectiveness. This study analyzed longitudinal adherence to the biennial invitations in the Capital Region of Denmark from 2008–2017. We analyzed participation rates for five-year age groups along with their percent changes in each invitation round using linear regressions. Participation in the mammography screening program increased from 73.1% to 83.1% from 2008–2017. The participation rate among all age groups increased from the first to the fifth round, with the oldest age group having the largest increase (average percent change = 3.66; p-value = 0.03).
The latitudinal and longitudinal allelopathic patterns of an invasive alligator weed (Alternanthera philoxeroides) in China
Authors: Hu Si-Yi , Gao Hui , Li Jian , Wang Yan-Hong , Gao An-Guo , Wen Ji-Hui , Balah Mohamed Abdelaziz , Wu Ai-Ping
Published: January 2023

Allelopathy has been considered a good explanation for the successful invasion of some invasive plants. However, the real latitudinal and longitudinal allelopathic effects on native species have rarely been documented since many exotics have spread widely. We conducted a Petri dish experiment to determine the latitudinal and longitudinal allelopathic patterns of an invasive alligator weed (Alternanthera philoxeroides) on a common crop (Lactuca sativa) in China, and find what determines the allelopathic intensity. The results showed that the allelopathic effects of A. philoxeroides increased with the latitude while decreased with the longitude. This indicated that A. philoxeroides used its allelopathy to gain competitive advantages more in its recent invaded communities than that in its early invaded ones as A. philoxeroides is expanding from southeast China to northwest China. Furthermore, we found that the allelopathic intensity of A. philoxeroide was negatively correlated to the leaf contents of soluble carbohydrate (SC), carbon (C) and nitrogen (N), but that was positively correlated to the leaf contents of soluble protein (SP), free amino acids (FAA), plant polyphenol (PP), phosphorus (P) and potassium (K). These results suggested that the allelopathic intensity of A. philoxeroide was more determined by the limited P and K nutrients as well as the intermediate allelochemicals (SP, FAA, PP) rather than the unlimited C, N and SC. Thus, we can speculate that the negative or positive effects of plant aqueous extracts are a function of not only the extract concentrations but also the trade-offs between inhibition and promotion of all components in the extracts. Then we could reduce the allelopathic effects of A. philoxeroide by controlling the component contents in the plant tissues, by fertilization or other managements, especially in the plant recent invaded communities.
Anticholinergic burden measures, symptoms, and fall-associated risk in older adults with polypharmacy: Development and validation of a prognostic model
Authors: Dinh Truc Sophia , Meid Andreas D. , Rudolf Henrik , Brueckle Maria-Sophie , González-González Ana I. , Bencheva Veronika , Gogolin Matthias , Snell Kym I. E. , Elders Petra J. M. , Thuermann Petra A. , Donner-Banzhoff Norbert , Blom Jeanet W. , van den Akker Marjan , Gerlach Ferdinand M. , Harder Sebastian , Thiem Ulrich , Glasziou Paul P. , Haefeli Walter E. , Muth Christiane
Published: January 2023

Background

Anticholinergic burden has been associated with adverse outcomes such as falls. To date, no gold standard measure has been identified to assess anticholinergic burden, and no conclusion has been drawn on which of the different measure algorithms best predicts falls in older patients from general practice. This study compared the ability of five measures of anticholinergic burden to predict falls. To account for patients’ individual susceptibility to medications, the added predictive value of typical anticholinergic symptoms was further quantified in this context.

Methods and findings

To predict falls, models were developed and validated based on logistic regression models created using data from two German cluster-randomized controlled trials. The outcome was defined as “≥ 1 fall” vs. “no fall” within a 6-month follow-up period. Data from the RIME study (n = 1,197) were used in model development, and from PRIMUM (n = 502) for external validation. The models were developed step-wise in order to quantify the predictive ability of anticholinergic burden measures, and anticholinergic symptoms. In the development set, 1,015 patients had complete data and 188 (18.5%) experienced ≥ 1 fall within the 6-month follow-up period. The overall predictive value of the five anticholinergic measures was limited, with neither the employed anticholinergic variable (binary / count / burden), nor dose-dependent or dose-independent measures differing significantly in their ability to predict falls. The highest c-statistic was obtained using the German Anticholinergic Burden Score (0.73), whereby the optimism-corrected c-statistic was 0.71 after interval validation using bootstrapping and 0.63 in the external validation. Previous falls and dizziness / vertigo had the strongest prognostic value in all models.

Conclusions

The ability of anticholinergic burden measures to predict falls does not appear to differ significantly, and the added value they contribute to risk classification in fall-prediction models is limited. Previous falls and dizziness / vertigo contributed most to model performance.
Latent CMV infection of Lymphatic endothelial cells is sufficient to drive CD8 T cell memory inflation
Authors: Munks Michael W. , Rott Katherine , Nesterenko Pavlo A. , Smart Savannah M. , Williams Venasha , Tatum Angela , Xu Guangwu , Smith Tameka , Murray Susan E. , Hill Ann B.
Published: January 2023

CMV, a ubiquitous herpesvirus, elicits an extraordinarily large T cell response that is sustained or increases over time, a phenomenon termed ‘memory inflation.’ Remarkably, even latent, non-productive infection can drive memory inflation. Despite intense research on this phenomenon, the infected cell type(s) involved are unknown. To identify the responsible cell type(s), we designed a Cre-lox murine CMV (MCMV) system, where a spread-deficient (ΔgL) virus expresses recombinant SIINFEKL only in Cre+ host cells. We found that latent infection of endothelial cells (ECs), but not dendritic cells (DCs) or hepatocytes, was sufficient to drive CD8 T cell memory inflation. Infection of Lyve-1-Cre and Prox1-CreERT2 mice revealed that amongst EC subsets, infection of lymphatic ECs was sufficient. Genetic ablation of β2m on lymphatic ECs did not prevent inflation, suggesting another unidentified cell type can also present antigen to CD8 T cells during latency. This novel system definitively shows that antigen presentation by lymphatic ECs drives robust CD8 T cell memory inflation.
The opportunistic pathogen Pseudomonas aeruginosa exploits bacterial biotin synthesis pathway to benefit its infectivity
Authors: Shi Yu , Cao Qin , Sun Jingdu , Hu Xiaofang , Su Zhi , Xu Yongchang , Zhang Huimin , Lan Lefu , Feng Youjun
Published: January 2023

Pseudomonas aeruginosa is an opportunistic pathogen that predominantly causes nosocomial and community-acquired lung infections. As a member of ESKAPE pathogens, carbapenem-resistant P. aeruginosa (CRPA) compromises the limited therapeutic options, raising an urgent demand for the development of lead compounds against previously-unrecognized drug targets. Biotin is an important cofactor, of which the de novo synthesis is an attractive antimicrobial target in certain recalcitrant infections. Here we report genetic and biochemical definition of P. aeruginosa BioH (PA0502) that functions as a gatekeeper enzyme allowing the product pimeloyl-ACP to exit from fatty acid synthesis cycle and to enter the late stage of biotin synthesis pathway. In relative to Escherichia coli, P. aeruginosa physiologically requires 3-fold higher level of cytosolic biotin, which can be attributed to the occurrence of multiple biotinylated enzymes. The BioH protein enables the in vitro reconstitution of biotin synthesis. The repertoire of biotin abundance is assigned to different mouse tissues and/or organ contents, and the plasma biotin level of mouse is around 6-fold higher than that of human. Removal of bioH renders P. aeruginosa biotin auxotrophic and impairs its intra-phagosome persistence. Based on a model of CD-1 mice mimicking the human environment, lung challenge combined with systemic infection suggested that BioH is necessary for the full virulence of P. aeruginosa. As expected, the biotin synthesis inhibitor MAC13772 is capable of dampening the viability of CRPA. Notably, MAC13772 interferes the production of pyocyanin, an important virulence factor of P. aeruginosa. Our data expands our understanding of P. aeruginosa biotin synthesis relevant to bacterial infectivity. In particular, this study represents the first example of an extracellular pathogen P. aeruginosa that exploits biotin cofactor as a fitness determinant, raising the possibility of biotin synthesis as an anti-CRPA target.
Spatial wave solutions for generalized atmospheric Ekman equations
Authors: Fečkan Michal , Guan Yi , Wang JinRong
Published: January 2023

In this paper, we use Prandtl mixing-length theory and semiempirical
theory to extend the classical problem of the wind in the steady
atmospheric Ekman layer with constant eddy viscosity. New generalized
atmospheric Ekman equations are established and qualitative properties of
the corresponding ODEs are studied. Spatial wave solutions results for the
nonlinear and implicit equations with different nonlinearities are
presented.
Infinitely many homoclinic solutions for a class of damped vibration
problems
Authors: Xu Huijuan , Jiang Shan , Liu Guanggang
Published: January 2023

In this paper, we consider the multiplicity of homoclinic solutions for the following damped vibration problems

x
¨

(
t
)
+
B

x
˙

(
t
)
−

A
(
t
)
x
(
t
)
+

H

x

(
t
,
x
(
t
)
)
=
0
,
where
A
(
t
)
∈

(

R

,

R

N

)
is a symmetric matrix for all
t
∈

R

,
B
=
[

b

i
j

]
is an antisymmetric
N
×

N
constant matrix, and
H
(
t
,
x
)
∈

C

1

(

R

×

B

δ

,

R

)
is only locally defined near the origin in
x
for some
δ

>
0
. With the nonlinearity
H
(
t
,
x
)
being partially sub-quadratic at zero, we obtain infinitely many homoclinic solutions near the origin by using a Clark's theorem.
Deliniation of metropolitan areas in Poland: A functional approach
Authors: Gawrońska-Nowak Bogna , Lis Piotr , Zadorozhna Olha
Published: January 2023

elineation of urban functional areas helps policymakers and urban planners understand the connections between the core cities and areas surrounding them, and subsequently develop policies and solutions that can serve local populations. This article develops a readily applicable econometric method for delineation that considers functional aspects of cities and their surroundings. We perform delineation analysis using the data for 78 Polish core cities, grouping them by population size. Using the satellite data on lights emitted at night, population density, commuter numbers as well as the number of houses and apartments built in each commune, we apply a threshold regression model to determine the boundaries of functional urban areas. Our main results suggest that the mean radius of functional urban areas (FUAs) around the largest (most populous) cities is, on average, 21 km, while it is between 13 and 16 km for smaller cities. We then test how the econometric results compare with the perceptions of local inhabitants through a citizen science project (CSP) conducted as a robustness check.
The early-stage entrepreneurial activity of women in individualistic versus collectivist country groups: Motives, drivers and inhibitors
Authors: Apostol Stefan
Published: January 2023

The purpose of this paper is to investigate whether differences in female entrepreneurial rates are explained by inherited cultural, societal, and technological factors. Women's early-stage entrepreneurial activity in two groups of countries is examined in this study. As part of the analysis, we used data from the Global Entrepreneurship Monitor and employed Logistic Regression, the Synthetic Minority Oversampling Technique, and Firth logistics for rare events. Collectivist countries have higher rates of early-stage entrepreneurial activity among women, but these occur in less technologically advanced sectors. Women’s primary motivation for entrepreneurship in countries with lower disposable personal income is necessity. New technology adoption rates in early-stage entrepreneurial activity are significantly higher in collectivist countries. Young women's entrepreneurial rates are slightly affected by the loneliness phenomenon. study's weaknesses are the overconfidence of interviewees in their ability to self-assess their skills, the low rate of women entrepreneurs, and the omission of essential variables due to missing data. This study tests the adage that individualistic behavior promotes entrepreneurship and examines the impact of societal variables on women's entrepreneurship, contrary to certain assumptions made in the GEM report. The study contributes to the body of knowledge regarding female entrepreneurship.
Management methods and tools in family businesses: Impact on the effectiveness of achieving goals
Authors: Biel Magdalena , Ślusarczyk Beata
Published: January 2023

Efficient management at family businesses, like all other enterprises, requires the use of appropriate methods and tools. However, in many cases, the people managing these entities do not have any formal business education and often follow their intuition and act on experience gained over the years. The purpose of this article is to determine the extent to which select management methods and tools are used in Polish family businesses and to examine their impact on the effectiveness of achieving various objectives. A survey was conducted on a group of 182 managers of family businesses from Poland, who were asked about the effectiveness of achieving goals and the methods and tools used in management. The goals have been aggregated into three main groups: family goals, business goals, and a mix of family and business goals. Then, using statistical methods, the impact of the selected management methods and tools on the effectiveness of these three groups of objectives was examined. The conducted analysis has shown that family businesses in Poland make little use of professional management methods and tools and are rather limited to the intuitive use of the simplest methods, which they often cannot even professionally name. The research results indicate that the use of these methods only partially influences the effectiveness of achieving the set goals, and this impact can be observed in all three groups. In view of the above, the basic task of the broader family business environment is to improve the knowledge of professional management methods and tools among family business managers. From the scientific point of view, further research in this area is also necessary because little use of management methods and tools, especially those more professional, makes it difficult to broaden the study of the actual impact of these instruments on the effectiveness of achieving family business objectives
Automating the updated grade severity rating system (GSRS) using the Visual Basic.net programming language
Authors: Ampadu Vincent Michael , Ksaibati Khaled
Published: January 2023

Truck crashes on steep downgrades due to excessive brake heating, resulting from brake applications to control speeding, are a continuing cause of concern for the Wyoming Department of Transportation (WYDOT). In 2016, WYDOT funded a project to update the existing Grade Severity Rating System. Furthermore, in 2020, WYDOT commissioned a research project to automate the updated version of the mathematical model through an interactive, intuitive, aesthetically appealing and user-friendly Visual Basic.net objected-oriented software to simplify the computation of the maximum safe descent speed on these downgrades based on the truck weight. The software provides functionality for both the continuous Slope and separate downgrade methods. The primary beneficiaries of this software will be the highway agencies who will be able to estimate the maximum safe speed of descent for trucks with various weight categories and hence produce Weight Specific Speed (WSS) signs for each downgrade or a multigrade section.
ОСТЕОПОРОЗ СВЯЗАННЫЙ С БЕРЕМЕННОСТЬЮ И ЛАКТАЦИЕЙ: СЛУЧАЙ ИЗ ПРАКТИКИ
Authors: Аббосхужаева Л. С. , Алиханова Н. М. , Исмаилов С. И. , Тахирова Ф. А. , Акрамова Г. Г. , Шакирова М. М.
Published: January 2023

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ОЦЕНКА ЭФФЕКТИВНОСТИ СКРИНИНГА НА ВЫЯВЛЕНИЕ ПАЦИЕНТОВ С ВЫСОКИМ РИСКОМ ПЕРЕЛОМОВ
Authors: Гладкова Е. Н. , Лесняк О. М. , Забежинская И. В. , Илюшин Ю. М. , Колбин М. Ю. , Танаев В. Г.
Published: January 2023

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РАСПРОСТРАНЕННОСТЬ ГЕРИАТРИЧЕСКИХ СИНДРОМОВ У ПАЦИЕНТОВ 60 ЛЕТ И СТАРШЕ С ПЕРЕЛОМОМ ПРОКСИМАЛЬНОГО ОТДЕЛА ПЛЕЧЕВОЙ КОСТИ
Authors: Горджеладзе Х. Г. , Белова К. Ю.
Published: January 2023

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ОСТЕОМАЛЯЦИЯ, ВЫЗВАННАЯ ФРФ23-СЕКРЕТИРУЮЩЕЙ ОПУХОЛЬЮ: СЕРИЯ ИЗ 38 КЛИНИЧЕСКИХ СЛУЧАЕВ
Authors: Гронская С. А. , Гребенникова Т. А. , Рожинская Л. Я. , Слащук К. Ю. , Дегтярев М. В. , Пшиялковская Е. Г. , Цориев Т. Т. , Мамедова Е. О. , Пигарова Е. А. , Родионова С. С. , Буклемишев Ю. В. , Федотов Р. Н. , Мельниченко Г. А. , Белая Ж. Е.
Published: January 2023

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КАЧЕСТВО ЖИЗНИ И ЕГО ВЗАИМОСВЯЗЬ С ЛОКОМОТОРНЫМИ ФУНКЦИЯМИ У ЖЕНЩИН С РЕВМАТОИДНЫМ АРТРИТОМ
Authors: Добровольская О. В. , Феклистов А. Ю. , Демин Н. В. , Торопцова Н. В.
Published: January 2023

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АНАЛИЗ УРОВНЯ ВИТАМИНА D В ЗАВИСИМОСТИ ОТ СОСТОЯНИЯ ЛОКОМОТОРНЫХ ФУНКЦИЙ У ЖЕНЩИН С РЕВМАТОИДНЫМ АРТРИТОМ
Authors: Добровольская О. В. , Сорокина А. О. , Самаркина Е. Ю. , Черкасова М. В. , Торопцова Н. В.
Published: January 2023

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КАЧЕСТВО ОПРЕДЕЛЕНИЯ ВИТАМИНА D(ОН) В КРОВИ И РОЛЬ КАЛЬЦИДИОЛА В ПОДДЕРЖАНИИ ЗДОРОВЬЯ АТЛЕТОВ
Authors: Дорофейков В. В. , Зырянова И. В.
Published: January 2023

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ВЗАИМОСВЯЗЬ МЕЖДУ УРОВНЕМ НЕСФАТИНА-1 И ПОКАЗАТЕЛЯМИ КОСТНОГО РЕМОДЕЛИРОВАНИЯ У ПАЦИЕНТОВ С РЕВМАТОИДНЫМ АРТРИТОМ
Authors: Зборовская И. А. , Александров А. В. , Квливидзе Т. З. , Полякова Ю. В. , Папичев Е. В. , Сивордова Л. Е. , Ахвердян Ю. Р. , Заводовский Б. В.
Published: January 2023

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КЛИНИЧЕСКИЙ ОПЫТ ПРИМЕНЕНИЯ REMS-ДЕНСИТОМЕТРИИ В РФ
Authors: Иванов С. Н.
Published: January 2023

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ОСТЕОПОРОЗ У МУЖЧИН В ГРУЗИНСКОЙ ПОПУЛЯЦИИ - ПОДХОДЫ К ЛЕЧЕНИЮ
Authors: Киласония Л. О. , Цагарели М. , Лагвилава Л. , Копалиани М. , Долидзе Н. , Рухадзе Т.
Published: January 2023

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ВЛИЯНИЕ ДЕФИЦИТА ВИТАМИНОВ ГРУППЫ В И/ИЛИ КАЛЬЦИЯ И МАГНИЯ НА КОРРЕКЦИЮ НЕДОСТАТОЧНОСТИ ВИТАМИНА D У КРЫС
Authors: Коденцова В. М. , Леоненко С. Н. , Вржесинская О. А. , Сокольников А. А.
Published: January 2023

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КОНСЕНСУС РОССИЙСКОЙ АССОЦИАЦИИ ПО ОСТЕОПОРОЗУ ПО ПОРОГУ ВМЕШАТЕЛЬСТВА FRAX ДЛЯ МУЖЧИН РОССИЙСКОЙ ФЕДЕРАЦИИ: РЕЗУЛЬТАТЫ ДЕЛФИ ГОЛОСОВАНИЯ
Authors: Лесняк О. М. , Гладкова Е. Н. , Баранова И. А. , Белая Ж. Е. , Белова К. Ю. , Евстигнеева Л. П. , Ершова О. Б. , Заводовский Б. В. , Косматов О. В. , Мягкова М. А. , Никитинская О. А. , Оттева Э. Н. , Полякова Ю. В. , Сивордова Л. Е. , Скрипникова И. А. , Сулейманова А. К. , Торопцова Н. В. , Цориев Т. Т.
Published: January 2023

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ТРУДНОСТИ В ДИАГНОСТИКЕ И ЛЕЧЕНИИ БОЛЕЗНИ ПЕДЖЕТА КОСТЕЙ: РАЗБОР КЛИНИЧЕСКИХ СЛУЧАЕВ
Authors: Мазуренко С. О.
Published: January 2023

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УРОВЕНЬ ИНФОРМИРОВАННОСТИ ПО ПРОБЛЕМЕ ОСТЕОПОРОЗА У ВРАЧЕЙ, РАБОТАЮЩИХ В ОТДЕЛЕНИЯХ МЕДИЦИНСКОЙ РЕАБИЛИТАЦИИ, И ЭФФЕКТИВНОСТЬ ДОПОЛНИТЕЛЬНОГО ПРОФЕССИОНАЛЬНОГО ОБРАЗОВАНИЯ
Authors: Марченкова Л. А. , Крюкова И. В.
Published: January 2023

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РАЗРАБОТКА ГЕНЕТИЧЕСКОЙ МОДЕЛИ ПРОГНОЗИРОВАНИЯ РИСКА ОСТЕОПОРОТИЧЕСКИХ ПЕРЕЛОМОВ У ЖЕНЩИН
Authors: Морозик П. М. , Руденко Э. В. , Кобец Е. В. , Руденко Е. В. , Самоховец О. Ю. , Шибеко О. В.
Published: January 2023

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ОСТЕОАРТРИТ КАК ПРИЧИНА ОСТРОГО СУСТАВНОГО СИНДРОМА: ОЦЕНКА ВЛИЯНИЯ ТЕРАПИИ НА КЛИНИЧЕСКИЕ И ЛАБОРАТОРНЫЕ ПОКАЗАТЕЛИ ПАЦИЕНТОВ
Authors: Повзун А. С. , Щемелева Е. В. , Повзун К. А. , Ковальчук Е. Ю. , Рысев А. В.
Published: January 2023

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НИЗКОЭНЕРГЕТИЧЕСКИЕ ПЕРЕЛОМЫ У БОЛЬНЫХ С ПНЕВМОНИЕЙ, ВЫЗВАННОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИЕЙ COVID-19, И ИХ ВЛИЯНИЕ НА ПРОГНОЗ ЗАБОЛЕВАНИЯ
Authors: Семенова Т. С. , Мазуренко С. О. , Ермолаева Л. Г.
Published: January 2023

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ФАКТОРЫ РИСКА ОСТЕОПОРОЗА У ПАЦИЕНТОВ С СИСТЕМНОЙ СКЛЕРОДЕРМИЕЙ
Authors: Сорокина А. О. , Демин Н. В.
Published: January 2023

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КОМПОЗИЦИОННЫЙ СОСТАВ ТЕЛА У БОЛЬНЫХ РЕВМАТИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ
Authors: Сорокина А. О. , Феклистов А. Ю. , Добровольская О. В. , Демин Н. В. , Торопцова Н. В.
Published: January 2023

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ВЗАИМОСВЯЗЬ ВИТАМИНА D И РАЗЛИЧНЫХ КЛИНИЧЕСКИХ И ЛАБОРАТОРНЫХ ПАРАМЕТРОВ У БОЛЬНЫХ СТАРЧЕСКОГО ВОЗРАСТА И ДОЛГОЖИТЕЛЕЙ С ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА
Authors: Тополянская С. В. , Елисеева Т. А. , Санина А. И. , Турна О. И. , Романова М. А. , Вакуленко О. Н.
Published: January 2023

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СВЯЗЬ УРОВНЯ ВИТАМИНА Д И КАЛЬЦИЯ С ИЗМЕНЕНИЯМИ ПОКАЗАТЕЛЕЙ ФУНКЦИИ ПЕЧЕНИ У ПАЦИЕНТОВ, СТРАДАЮЩИХ СЕРДЕЧНО-СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИ
Authors: Турянская Ю. В. , Мелкозерова Н. Ю.
Published: January 2023

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СОВРЕМЕННАЯ КОНЦЕПЦИЯ САНАТОРНО-КУРОРТНОГО ЛЕЧЕНИЯ ПАЦИЕНТОВ С ЗАБОЛЕВАНИЯМИ КОСТНО-МЫШЕЧНОЙ СИСТЕМЫ
Authors: Фесюн А. Д. , Яковлев М. Ю.
Published: January 2023

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ОСОБЕННОСТИ ОБМЕНА ВИТАМИНА D В ПЛАЦЕНТЕ
Authors: Шелепова Е. С. , Зазерская И. Е. , Костарева А. А.
Published: January 2023

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ИССЛЕДОВАНИЕ ЭПИГЕНЕТИЧЕСКИХ И ФАРМАКОГЕНЕТИЧЕСКИХ МАРКЕРОВ ОСТЕОПОРОЗА И ПОЛИГЕННАЯ ОЦЕНКА РИСКА ПЕРЕЛОМОВ У ЖЕНЩИН ИЗ ВОЛГО-УРАЛЬСКОГО РЕГИОНА РОССИИ
Authors: Ялаев Б. И. , Хусаинова Р. И.
Published: January 2023

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Mixing Methods
Authors: Fritsch Bernhard , Götz Steven , Filser Wolfgang , Reinfeld Michaela , Klose Christoph , Vitti Paolo
Published: January 2023

Accompanying excavation activities in the area of the Roman luxury villa of Capo di Sorrento, 3D models of the landscape and relevant features have been created using mostly Structure-from-Motion (SfM) since 2015. With this method, it was possible to create a digital surface model of the excavation site combining terrestrial, aerial, and underwater photography. From this 3D model and other, more detailed sub-models of specific objects or areas, various new data were created that greatly enhance excavation documentation and the assessment of features. While some of these data, such as orthophotos generated from SfM models, are now standard practice on excavations, other products require more effort. The research project on the villa of Capo di Sorrento went beyond the results that were obtained from 3D models, and are usually presented as 2D pictures, to expand on the 3D data collected in the field in later work. In particular, the reconstruction of a grotto triclinium based on SfM models is combined with manual and tacheometric documentation to yield far-reaching insights into the architecture, furnishings, and orientation of the rooms on the north side of the pars maritima. Renderings of 3D data are used to simulate the views from certain points. This reconstruction is thus based on both the archaeological features and the specifications of the surface models and as such combines different methods of 3D processing, and fuses digital data with analog research results. Over the course of several excavation campaigns, a corpus of 3D products has grown within the research project. The respective methods of data acquisition, processing and analysis are primarily due to the landscape conditions of the study area. The detailed representation of the rocky subsoil – i.e. the heavily manipulated limestone plateau at the northern end of the cape – above and below water played a central role.
Legal education abroad: Colombian legal graduates and the social effects of LL.M. degrees
Authors: Ramírez César
Published: January 2023

This paper analyzes the social effects of U.S. Master of Laws degrees (LL.M.) in the Colombian juridical field. Therefore, this paper asks: what are the selection requirements of U.S. LL.M. programs? How do selection requirements reproduce social hierarchies in a country such as Colombia? To address these questions, this paper first describes the admission criteria of LL.M. programs in U.S. universities by relying on qualitative data such as the universities’ description of their selection mechanisms and the costs of admissions. Then, using primary and secondary quantitative and qualitative data, the paper describes how selection criteria reproduce the Colombian legal field’s social hierarchies. The article focuses on four selection requirements: the English proficiency requirement, grades, C/V, letters of recommendation, and the recognition of the degree. Finally, the paper concludes that current selection mechanisms reproduce social hierarchies in Colombia’s legal profession
Self-Supervised and Interpretable Data Cleaning with Sequence Generative Adversarial Networks
Authors: Peng Jinfeng , Shen Derong , Tang Nan , Liu Tieying , Kou Yue , Nie Tiezheng , Cui Hang , Yu Ge
Published: January 2023

We study the problem of self-supervised and interpretable data cleaning, which automatically extracts interpretable data repair rules from dirty data. In this paper, we propose a novel framework, namely Garf, based on sequence generative adversarial networks (SeqGAN). One key information Garf tries to capture is data repair rules (for example, if the city is "Dothan", then the county should be "Houston"). Garf employs a SeqGAN consisting of a generator
G
and a discriminator
D
that trains
G
to learn the dependency relationships (
e.g.
, given a city value "Dothan" as input, the county can be determined as "Houston"). After training, the generator
G
can be used to generate data repair rules, but may contain both trusted and untrusted rules, especially when learning from dirty data. To mitigate this problem, Garf further updates the learned relationships with another discriminator
D'
to iteratively improve the quality of both rules and data. Garf takes advantages of both logical and learning-based methods, which allow cleaning dirty data with high interpretability and have no requirements for prior knowledge and training data. Extensive experiments on real-world and synthetic datasets demonstrate the effectiveness of Garf. Garf achieves new state-of-the-art data cleaning result with high accuracy, through learning from dirty datasets without human supervision.
iEDeaL
Authors: Wang Qitong , Whitmarsh Stephen , Navarro Vincent , Palpanas Themis
Published: January 2023

Epilepsy is a chronic neurological disease, ranked as the second most burdensome neurological disorder worldwide. Detecting Interictal Epileptiform Discharges (IEDs) is among the most important clinician operations to support epilepsy diagnosis, rendering automatic IED detection based on electroencephalography (EEG) signals an important topic. However, most existing solutions were designed and evaluated upon artificially balanced IED datasets, which do not conform to the real-world highly imbalanced scenarios. In this work, we propose the iEDeaL framework for automatic IED detection in challenging real-world use cases. The main components of iEDeaL are the new SC neural network architecture, to efficiently detect IEDs on raw EEG series instead of extracted features, and SaSu, a novel loss function to train SC by optimizing the
F
β
-score. Experiments on two real-world imbalanced IED datasets verify the advantages of iEDeaL in offering more accurate and efficient IED detection when compared with other state-of-the-art deep learning-based and spectrogram feature-based solutions.
Biodegradation of synthetic PVP biofilms using natural materials and nanoparticles
Authors: Alzain Hassan , Hussein Karim , Jabr Ibrahim , Alsubaie Abdullah
Published: January 2023

Biodegradable nanofilms from polyvinyl pyrrolidone (PVP), carboxymethyl cellulose (CMC), citric acid (CA), glycerol (G), and zinc oxide nanoparticles (ZnO-NPs) were prepared using different ZnO concentrations and different electron beam irradiation doses, enabling crosslinking formation. The prepared films were characterized by X-ray diffractometer, Fourier transform infrared spectroscopy, thermogravimetric analyser, and transmission electron microscopy. The swelling percentage of PVP:CMC films was ordered in the sequence of composition ratio 1:2 > 1:1 > 2:1. Results showed decrease in swelling capacity accompanied by increase in gelation percentage of (PVP:CMC)/CA/G)/ZnO nanofilms as the irradiation dose increased up to 20 kGy. The tensile strength of (PVP:CMC) films increased by the incorporation of ZnO-NPs and increasing the irradiation dose. The thermal stability of the prepared (PVP:CMC)/CA/G/ZnO nanofilms was enhanced as the irradiation dosage increased. The water vapour transmission rate of the irradiated films was decreased. The biodegradability of the prepared nanofilms was monitored during 16 weeks and it exceeded 65% weight loss from the original blank weight. Moreover, the nanofilms exhibit antimicrobial activity against fungi, Gram-negative, and Gram-positive bacteria. The broad antimicrobial activity spectrum of the prepared nanofilms increased as the concentration of ZnO-NPs increased. These results suggested that (PVP:CMC)/CA/G/ZnO nanofilms can serve as biodegradable materials in various applications characterized by antimicrobial activity.
(Un-)persönliches Schreiben in der Wissenschaftssprache?
Authors: Matthies Jochen
Published: January 2023

Die vorliegende Studie beschäftigt sich mit Agensdemotion und Verfasserreferenz im Deutschen als fremder Wissenschaftssprache. Es wird eine vergleichende Korpusstudie mit deutschsprachigen Masterarbeiten von muttersprachlichen und polnischen Studierenden durchgeführt. Eine quantitative Auswertung ergibt signifikante Unterschiede zwischen den beiden Gruppen. Der Vergleich mit einer vorausgegangenen Studie mit Bachelorarbeiten zeigt aber auch, dass die Unterschiede zwischen L1- und L2-Sprechern und -Sprecherinnen auf Masterniveau geringer werden. Insbesondere seltene Konstruktionen, die auf dem niedrigeren Niveau unterrepräsentiert sind, nähern sich mit steigender Expertise in ihrer Häufigkeit dem L1-Muster an. Fehleranalysen zeigen außerdem auf, dass auch auf dem hohen Niveau der Masterarbeiten noch Einflüsse aus der L1 Polnisch zu erkennen sind.
Crystal structure of S-(benzo[d]thiazol-2-yl)-N-(tert-butyl)thiohydroxylamine, C11H14N2S2
Authors: Duan Yong-Hua , Yuan Fei , Hu Shi-Biao , Bian Jiang , Guo Ya-Fei
Published: January 2023

C11H14N2S2, monoclinic, I2/a (no. 15), a = 11.4278(8) Å, b = 8.5816(6) Å, c = 25.1115(18) Å, β = 95.173(6)°, V = 2452.6(3) Å3, Z = 8, Rgt
(F) = 0.0416, wRref
(F
2) = 0.1169, T = 293 K.
Synthesis and crystal structure of 8-bromo-3-(1H-pyrazole-1-carbonyl)-2H-chromen-2-one, C13H7BrN2O3
Authors: Hao Zhi-Feng , Zhu Shi-Jie , Lei Chuan-Wen , Zhou Ying
Published: January 2023

C13H7BrN2O3, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 7.2968(6) Å, b = 7.6743(6) Å, c = 11.5698(12) Å, α = 77.255(8)°, β = 73.573(8)°, γ = 73.509(7)°, V = 588.90(10) Å3, Z = 2, R

gt
(F) = 0.0459, wR

ref
(F
2) = 0.1089, T = 220 K.
Crystal structure of pentacarbonyl-(μ
2-ethane-1,2-dithiolato-κ
4
S:S,S′:S′)-(diphenyl(o-tolyl)phosphine-κ
1
P)diiron (Fe–Fe), C26H21Fe2O5PS2
Authors: Bi Lu-Yan , Liu Xu-Feng
Published: January 2023

C26H21Fe2O5PS2, orthorhombic, Pna21 (no. 33), a = 20.9559(8) Å, b = 14.1567(6) Å, c = 9.1976(4) Å, V = 2728.6(2) Å3, Z = 4, Rgt
(F) = 0.0217, wRref
(F
2) = 0.0570, T = 296(2) K.
The use of material resources in vocabulary explanations: a conversation analytic inquiry
Authors: Koç Tuncay , Ergül Hatice
Published: January 2023

Recent studies have examined the interactional management of verbal and non-verbal vocabulary explanations in second language (L2) classrooms. However, the use of material resources in vocabulary explanations has not been fully investigated yet. Based on a corpus of fourteen class-hours of (50-min each) video recordings of an L2 Oral Communication classroom at a higher education setting in Turkey, this study explores how material resources are employed in vocabulary explanation sequences in combination with talk and gestures. Using the micro-analytic lens of multimodal Conversation Analysis (CA) for the examination of the detailed transcriptions of vocabulary explanation sequences with material resources, three different patterns were identified: (1) gesture + material resources; (2) talk + gesture + material resources; and (3) scene enactment + material resources. The findings of this study contribute to classroom interaction research, more specifically to studies on vocabulary teaching, by providing a micro-analytic account of how material resources are employed in vocabulary explanations.
Vitamin D: marker, measurand & measurement
Authors: Dirks Niek F , Cavalier Etienne , Heijboer Annemieke C
Published: January 2023

The measurement of vitamin D metabolites aids in assessing vitamin D status and in diagnosing disorders of calcium homeostasis. Most laboratories measure total 25-hydroxyvitamin D (25(OH)D), while others have taken the extra effort to measure 25(OH)D2 and 25(OH)D3 separately and additional metabolites such as 1,25-dihydroxyvitamin D and 24,25-dihydroxyvitamin D. The aim of this review is to provide an updated overview of the main markers of vitamin D metabolism, define the intended measurands, and discuss the advantages and disadvantages of the two most widely used assays, automated assays and liquid chromatography–tandem mass spectrometry (LC-MS/MS). Whether using the easy and fast automated assays or the more complex LC-MS/MS, one should know the pitfalls of the used technique in order to interpret the measurements. In conclusion, automated assays are unable to accurately measure 25(OH)D in all patient groups, including persons using D2. In these cases, an LC-MS/MS method, when appropriately developed and standardized, produces a more reliable measurement.
Preparation and characterization of cellulose triacetate from cocoa pod husk
Authors: Bamba Massé , Assanvo Edja Florentin , Kouassi Esaïe Kouadio Appiah , Soro Doudjo , Ouattara Leygnima Yaya , Yao Kouassi Benjamin , Drogui Allali Patrick , Tyagi Dayal Rajeshwar
Published: January 2023

The valorisation of agricultural residues into a high value-added product is necessary to respond to the global environmental concerns caused by the pollution of agricultural waste. The objective of this study was to shed light on a new value-added usage of cocoa pod husk (CPH) for the synthesis of cellulose triacetate (CTA). Alkaline treatment with sodium hydroxide (5 wt%) followed by bleaching process with (2 wt%) hydrogen peroxide was found effective for the extraction of cellulose from CPH. The percentage of cellulose obtained was 80.5% with a yield of 54%. The CTA was synthesised by a explore new way acetylation reaction in the presence of acetic acid, acetic anhydride, and sulphuric acid. The CTA obtained had a degree of substitution of 2.87 and a percentage of acetylated group of 43.8%, as determined by titration. The result of Fourier transform infrared spectroscopy showed the appearance of the stretching of the ester and the acetyl groups, indicating the formation of CTA. X-ray diffraction showed that the crystallinity index of CPH cellulose was 38.4%, while indicating the semi-crystalline nature of CTA produced. Scanning electron microscopy confirmed a change in the morphology of CTA after acetylation. X-ray energy dispersive analysis showed that the CTA was mainly composed of carbon and oxygen.
Properties of acrylonitrile styrene acrylate copolymer modified eucalyptus/polyvinyl chloride composites
Authors: Wang Min , Yang Xingxing , Duan Guoyan , Wang Wei
Published: January 2023

Eucalyptus/polyvinyl chloride (PVC) composites were prepared by extrusion molding with eucalyptus as filler, PVC as matrix, and different contents of acrylonitrile styrene acrylate copolymer (ASA). The effects of different ASA content on the mechanical properties, water absorption properties, and thermal stability of eucalyptus/PVC composites were studied. The morphology of the tensile section of the composites was observed by scanning electron microscopy (SEM). The results showed that the addition of ASA could improve the mechanical properties, heat resistance, and interfacial compatibility of eucalyptus/PVC composites. It also could reduce the water absorption of the composites. When ASA content was 10 wt%, the mechanical properties and heat resistance of eucalyptus/PVC composite were the best, and the water absorption in 24 h was the lowest.
Historical Aspects of the Institute of Evidence and Proof in Civil Proceedings in Latvia (1918–1940)
Authors: Jurkeviča Tatjana
Published: January 2023

The institute of evidence is an integral part of achieving the objectives of civil proceedings, and only through it can effective civil protection be ensured in the courts. Within the framework of this paper, the concept and essence of evidence, as well as the general rules of proof in Latvia in the period from 1918 to 1940, are studied.
Differences of Legal Regulatiom in Financial Accounting and Corporate Income Tax
Authors: Endrijaitis Martynas
Published: January 2023

This paper discloses cases in which permanent differences between the legal regulation of financial accounting and corporate income tax arise, while revealing the significance of these differences in the fulfillment of a tax liability (corporate income tax)
A Novel Inpatient Buprenorphine Induction Program for Adolescents With Opioid Use Disorder
Authors: Trope Lee A. , Stemmle Monica , Chang Annie , Bashiri Nasrin , Bazazi Alexander R. , Lightfoot Marguerita , Congdon Jayme L.
Published: January 2023

BACKGROUND

Morbidity and mortality from nonprescribed opioid use and opioid use disorder (OUD) in adolescents have risen dramatically. Medication for opioid use disorder (MOUD) with buprenorphine reduces nonprescribed opioid use and prevents overdoses, though <5% of adolescents with OUD have timely access, partly because of barriers associated with buprenorphine induction. Induction in an inpatient pediatric setting has the potential to address such barriers and improve adolescent MOUD access.

METHODS

We developed and implemented a protocol for inpatient buprenorphine induction and linkage to MOUD care within a safety-net health system. After 1 year, we conducted descriptive analysis of participant characteristics, rates of induction completion and treatment linkage, and adverse events. We analyzed field notes from multidisciplinary huddles to identify implementation facilitators and barriers.

RESULTS

During May 2021 to July 2022, we completed 46 admissions for 36 patients aged 12 to 21 years. All used fentanyl and no other opioids. Forty of 46 (87%) admissions resulted in completed induction, and 3 additional patients never developed withdrawal symptoms and were discharged with maintenance buprenorphine. Linkage to ongoing treatment occurred within 2 weeks for 31 of 43 (72%) admissions for which buprenorphine was started. We identified facilitators and barriers to program implementation and maintenance.

CONCLUSION

These results provide promising preliminary evidence of the feasibility of inpatient buprenorphine induction for adolescents with OUD. Given the public health urgency and severe shortage of adolescent access to MOUD, these results prompt consideration of broader clinical implementation and research to facilitate rapid expansion of access to evidence-based OUD care.