bluuebunny/crossref_metadata_2025 huggingface dataset:
Structural and functional insights into the fly microRNA biogenesis factor Loquacious
Authors: Jakob Leonhard , Treiber Thomas , Treiber Nora , Gust Alexander , Kramm Kevin , Hansen Kerrin , Stotz Mathias , Wankerl Ludwig , Herzog Franz , Hannus Stefan , Grohmann Dina , Meister Gunter
Published: February 2016

In the microRNA (miRNA) pathway, Dicer processes precursors to mature miRNAs. For efficient processing, double-stranded RNA-binding proteins support Dicer proteins. In flies, Loquacious (Loqs) interacts with Dicer1 (dmDcr1) to facilitate miRNA processing. Here, we have solved the structure of the third double-stranded RNA-binding domain (dsRBD) of Loqs and define specific structural elements that interact with dmDcr1. In addition, we show that the linker preceding dsRBD3 contributes significantly to dmDcr1 binding. Furthermore, our structural work demonstrates that the third dsRBD of Loqs forms homodimers. Mutations in the dimerization interface abrogate dmDcr1 interaction. Loqs, however, binds to dmDcr1 as a monomer using the identified dimerization surface, which suggests that Loqs might form dimers under conditions where dmDcr1 is absent or not accessible. Since critical sequence elements are conserved, we suggest that dimerization might be a general feature of dsRBD proteins in gene silencing.
Population-transplants by Philip II
Authors: Ellis J. R.
Published: February 2016

No abstract
Ν. Β. Κοσμά, Ο Λαγκαδάς. Ιστορία - Λαογραφία
Authors: Κωνσταντινίδης Ν. Α.
Published: February 2016

No abstract
Dr. Lothar Siegesmund, Griechisch - Makedonische Impressionen (Εντυπώσεις από την Ελληνική Μακεδονία)
Authors: Φόρης Βασίλειος Δ.
Published: February 2016

No abstract
Η άλωση της Θεσσαλονίκης στα 1430 και ο Σέρβος δεσπότης Γεώργιος Μπράνκοβιτς (Djuradj Brankovic)
Authors: Παπανδριανός Ιωάννης Α.
Published: February 2016

No abstract 
Ν. Π. Δελιαλή, Συμβολαί εις την Εκκλησιαστικήν Ιστορίαν της Κοζάνης, Ε'- Τα χαλκά αντικείμενα της Εκκλησίας του Αγίου Νικολάου Κοζάνης, ΣΤ' - Τα οικονομικά της Εκκλησίας του Αγίου Νικολάου Κοζάνης των ετών 1782-1802 (ανάτυπον εκ του Γ' - Δ' τόμου της "Οικοδομής", Επετηρίδος της Ιεράς Μητροπόλεως Σερβίων και Κοζάνης)
Authors: Παπουλίδης Κωνσταντίνος Κ.
Published: February 2016

No abstract 
Αθανασίου Γρ. Γερομιχαλού, Η εθνική δράσις του μητροπολίτου Πελαγονίας Ιωακείμ Φοροπούλου και αι εκθέσεις αυτού
Authors: Παπουλίδης Κωνσταντίνος Κ.
Published: February 2016

No abstract 
Ιωάννου Μ. Φουντούλη, Συμεών, Αρχιεπισκόπου Θεσσαλονίκης, τα λειτουργικά συγγράμματα τ. Ι Ευχαί και ύμνοι
Authors: Παπουλίδης Κωνσταντίνος Κ.
Published: February 2016

No abstract 
Εκλογές για μουχταροδημογεροντία στο Μπλάτσι της Κοζάνης (1888)
Authors: Τσάρας Γιάννης
Published: February 2016

No abstract
Από την ιδιωτικήν ζωήν ανθρώπων του λαού εις την αρχαίαν Μακεδονίαν
Authors: Κανατσούλης Δ.
Published: February 2016

No abstract
Η θεμελίωσις του πρώτου καθολικού ναού της Θεσσαλονίκης
Authors: Παπαστάθης Χαραλ. Κ.
Published: February 2016

No abstract
Και πάλι για τον Ιωάννη Κωττούνιο
Authors: Καραθανάσης Ιω. Ε.
Published: February 2016

No abstract
Raymond V. Schoder, Ancient Greece from the Air
Authors: Πέτσας Φώτιος Μ.
Published: February 2016

No abstract
Χερουβείμ, αρχιμανδρίτου, Σύγχρονες αγιορείτικες μορφές
Authors: Παπουλίδης Κωνσταντίνος Κ.
Published: February 2016

No abstract
Αι απολεσθείσαι τοιχογραφίαι της Παναγίας των Χαλκέων Θεσσαλονίκης
Authors: Ξυγγόπουλος Α.
Published: February 2016

No abstract
Οι δημοσιευμένες ομιλίες του Αρχιεπισκόπου Θεσσαλονίκης Ισιδώρου ως ιστορική πηγή για τη γνώση της πρώτης Τουρκοκρατίας στη Θεσσαλονίκη (1387-1403)
Authors: Βακαλόπουλος Απόστολος Ε.
Published: February 2016

No abstract
Η Μακεδονική πόλις από της εμφανίσεως της μέχρι των χρόνων του Μεγάλου Κωνσταντίνου
Authors: Κανατσούλη Δ.
Published: February 2016

No abstract
Η εξαγωγή χειρογράφων εξ Αγίου Όρους
Authors: Κυριακίδης Στ. Π.
Published: February 2016

No abstract
Υπήρξε επί Τουρκοκρατίας μητροπολιτικός ναός ο Αγ. Γεώργιος (Rotonda) και πότε;
Authors: Βακαλόπουλος Απόστολος
Published: February 2016

No abstract
Χριστοφόρου Νάλτσα, Ο Μακεδονικός Αγών εις την Δυτικήν Μακεδονίαν
Authors: Λαούρδας Βασ.
Published: February 2016

No abstract
Η συγγένεια του βιβλίου «Αόρατος πόλεμος» του Νικόδημου Αγιορείτη με το «Combattimento spirituale» του Lorenzo Scupoli
Authors: Παπουλίδης Κωνσταντίνος Κ.
Published: February 2016

No abstract
Les événements à Thessalonique au mois d'Avril en 1903 d’après les documents des archives historiques du Ministère des Affaires Étrangères de la Grèce
Authors: Νοτάρης Ιωάννης Σωτ.
Published: February 2016

No abstract
Οι Τζαμπλάκωνες: συμβολή εις την Βυζαντινήν Μακεδονικήν προσωπογραφίαν του ΙΔ' αιώνος
Authors: Θεοχαρίδης Γ. Ι.
Published: February 2016

No abstract
Βρεττανικές πηγές σχετικές με τον Μακεδονικόν Αγώνα (1901-1909)
Authors: Dakin Douglas
Published: February 2016

No abstract
Η σαρκοφάγος του Τιβέριου Κλαύδιου Λύκου βουλευτού
Authors: Θέμελης Πέτρος Γ.
Published: February 2016

No abstract
Eustazio di Tessalonica, La espugnazione di Tessalonica, testo critico, introduzione, annotazioni di Stilpon Kyriakidis, proemio di Bruno Lavaglini, versione italiana di Vincenzo Rotolo
Authors: Κριαράς Ε.
Published: February 2016

No abstract
Stilpon P. Kyriakides, Two studies on Modern Greek Folklore
Authors: Σκουτέρη Ελεονώρα
Published: February 2016

No abstract
Φώτη Ι. Παπανικολάου, Ιστορία του Κριμινίου
Authors: Κυριακίδης Στίλπων Π.
Published: February 2016

No abstract
Ιφιγενείας Γρ. Διδασκάλου, Το δημοτικό τραγούδι της Καστοριάς. Διαλέξις οργανωθείσα υπό της "Μακεδονικής Εστίας"
Authors: Κυριακίδης Στίλπων Π.
Published: February 2016

No abstract
Γ. Ι. Θεοχαρίδου, Ο ρόλος της Μακεδονίας εις την πολιτικήν και στρατιωτικήν ιστορίαν της Ελλάδος. Δύο διαλέξεις προς τελειοφοίτους στρατιωτικών σχολών
Authors: Κυριακίδης Στίλπων Π.
Published: February 2016

No abstract
Hugo Hepding (1878-1961)
Authors: Κυριακίδης Στίλπων Π.
Published: February 2016

No abstract
Ο Μ. Αλέξανδρος κατά τον Αρριανόν
Authors: Σκουφάκης Πέτρος
Published: February 2016

No abstract
Τα γεγονότα του 1821 στη Βόρεια Μολδαβία: Γεωργάκης Ολύμπιος και Ιωάννης Φαρμάκης
Authors: Γκαϊντατζής Νίκος
Published: February 2016

No abstract
Incidents survenus a la frontière de la Macédoine grecque et la question grecque (21 janvier 1946 - 21 octobre 1947)
Authors: Vacalopoulos Constantinos Ap.
Published: February 2016

Μέ τήν σύντομη αυτή εργασία του ό συγγραφέας εξετάζει τήν δραστηριότητα, πού άνέπτυξαν τό Συμβούλιο ’Ασφαλείας καί ή Γενική Συνέλευση του Ο.Η.Ε. για νά διευθετήσουν ορισμένες διαφορές, οί όποιες προέκυψαν μεταξύ της Ελλάδος καί των γειτονικών βαλκανικών κρατών έξ αίτιας παραβιάσεων των τελευταίων στά σύνορα τής έλληνικής Μακεδονίας. Ή πρόθεση
των οργάνων τού Ο.Η.Ε. καί των διαφόρων αντιπροσώπων των μελών του ήταν οχι μόνον νά αντιμετωπίσουν τήν διαταραχή τής ειρήνης στά βόρεια σύνορα τής έλληνικής Μακεδονίας, άλλα καί νά προχωρήσουν προς τήν έναρξη διαπραγματεύσεων γιά τήν αποκατάσταση ομαλών σχέσεων μεταξύ τών ενδιαφερομένων χωρών. Πραγματικά ή προσπάθεια του Ο.Η.Ε. στέφθηκε άπό τελική επιτυχία καί απέδειξε πολύ καθαρά τήν χρησιμότητα τών νέων συλλογικών οργάνων ασφαλείας.
Ο ανέκδοτος Κανονισμός της Ελληνικής Ορθοδόξου Κοινότητος Τυρνόβου Πελαγονίας
Authors: Παπαστάθης Χαράλαμπος Κ.
Published: February 2016

No abstract
Β. Γ. Σαμπανοπούλου, Εκκλησία και επαναστατικά κινήματα στην Κοζάνη
Authors: Χιονίδης Γεώργιος Χ.
Published: February 2016

No abstract
Κύριλλος Πατριάρχης Βουλγαρίας
Authors: Παπαστάθης Χαραλ. Κ.
Published: February 2016

No abstract
Διάφοροι οικογένειαι των Σερρών, Μελενίκου και μοναστηρίου Ρίλας κατα το έτος 1824
Authors: Βασδραβέλλης Ι.
Published: February 2016

No abstract
Έλεγχος κριτικής
Authors: Γεωργίου Χ. Γ.
Published: February 2016

No abstract
Τηλεμάχου Μ. Κατσουγιάννη, Περί των Βλάχων των ελληνικών χωρών. Β', Έκ του βίου και της ιστορίας των Κουτσοβλάχων επί τουρκοκρατίας
Authors: Παπαδόπουλος Στέφανος Ι.
Published: February 2016

No abstract
Αρχείον Στεφάνου Νικ. Δραγούμη. Ανέκδοτα έγγραφα για την επανάστασι του 1878 στη Μακεδονία. Εισαγωγή και επιμέλεια Ιωάννου Σωτ. Νοτάρη
Authors: Παπαδόπουλος Στέφανος Ι.
Published: February 2016

No abstract
The role of COP1 in repression of photoperiodic flowering
Authors: Xu Dongqing , Zhu Danmeng , Deng Xing Wang
Published: February 2016

Plants use the circadian clock as a timekeeping mechanism to regulate photoperiodic flowering in response to the seasonal changes. CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1), initially identified as a central repressor of seedling photomorphogenesis, was recently shown to be involved in the regulation of light input to the circadian clock, modulating the circadian rhythm and flowering. COP1 encodes a RING-finger E3 ubiquitin ligase and works in concert with SUPPRESSOR ofphyA-105(SPA) proteins to repress photoperiodic flowering by regulating proteasome-mediated degradation of CONSTANS (CO), a central regulator of photoperiodic flowering. In addition, COP1 and EARLY FLOWERING 3 (ELF3) indirectly modulateCOexpression via the degradation of GIGANTEA (GI). Here, we summarize the current understanding of the molecular mechanisms underlying COP1’s role in controlling of photoperiodic flowering.
Analysis of red autofluorescence (650-670nm) in epidermal cell populations and its potential for distinguishing contributors to 'touch' biological samples
Authors: Stanciu Cristina E. , Philpott M. Katherine , Bustamante Eduardo E. , Kwon Ye Jin , Ehrhardt Christopher J.
Published: February 2016

Interpretation of touch DNA mixtures poses a significant challenge for forensic caseworking laboratories.  Front end techniques that facilitate separation of contributor cell populations before DNA extraction are a way to circumvent this problem. The goal of this study was to survey intrinsic fluorescence of epidermal cells collected from touch surfaces and investigate whether this property could potentially be used to discriminate between contributor cell populations in a biological mixture.  Analysis of red autofluorescence (650-670nm) showed that some contributors could be distinguished on this basis. Variation was also observed between autofluorescence profiles of epidermal cell populations from a single contributor sampled on different days. This dataset suggests that red autofluorescence may be a useful marker for identifying distinct cell populations in some mixtures. Future efforts should continue to investigate the extrinsic or intrinsic factors contributing to this signature, and to identify additional biomarkers that could complement this system.
Features of Biological Action of Microwave Radiation on the Antiviral Defense of Whole Blood in Community-Acquired Pneumonia and in the Healthy People
Authors: Терехов  , Terekhov I. , Бондарь  , Bondar S.
Published: February 2016

The purpose of the study was to investigate the intracellular concentration factors of antiviral defense of cells whole blood of convalescents EAP and healthy individuals under the influence of low-intensity microwave irradiation of whole blood in vitro 1000 MHz. In accordance with the objectives of the study, in the lysates of mononuclear whole blood the authors determined by means of ELISAmethod the concentration of mitochondrial antiviral signaling protein MAVS, RIG-I-like receptor 3-type - helicase MDA-5, RIG-I-like receptor - helicase IFIH1, a transmembrane protein 173 (Tmeml73), interferon-regulated factors (IRF) 3, 7 and 8 subunits P50 and P65 nuclear transcription factor NF-kB, phosphorylated by serina in position 32 of the form of the inhibitor of nuclear transcription factor (ΙκΒ-α) and total concentrations. In addition, in the cell supernatant the authors assessed a spontaneous production by cells of the whole blood IFN-α, -|3.

It was definite the ability of a single 20-minute microwave exposure to increase in the phase of convalescence EP intracellular level in mononuclear most important regulatory proteins - MDA5, MAVS, Tmeml73, IRF8. The irradiation stimulates the production of antiviral interferon beta. In the healthy individuals irradiation contributes largely to the increase in intracellular MAVS. A smaller effect is observed for MDA5, Tmeml73. This single microwave irradiation enhances production of both IFN-alpha and beta, encouraging a greater degree of the latest products. A feature of the biological effects of radiation is its immune-modulator effect on the intracellular content of studied mediators.
The Principles of Differentiated Immunotherapy of Pro-Inflammatory Diseases of Different Genesis
Authors: Золоедов  , Zoloedov V. , Земсков  , Zemskov M. , Земскова  , Zemskova V. , Земсков  , Zemskov A. , Луцкий  , Lutskiy M.
Published: February 2016

The pathogenesis of various inflammatory diseases - deep pyodermia (DP), purulent soft tissue infection (PSTI), chronic pyelonephritis (SP) and chronic oophoritis (CO) is basis in the formation of diagnostically significant changes in routine hematological parameters and indicators of immune reactivity that can be represented in the form of specific formulas. So, the typical response of routine hematological tests on inflammation in patients from 4 groups was qualitatively universal standard, leukocytosis, neutrophilia, eosinophiles, monocytosis, lymphopenia, accelerated eryt-hrocyte sedimentation rate. In quantitative terms the differences were insignificant. When DP is relatively SP recorded higher leukocytosis and neutrophilia, relatively CO significantly less monocytosis and the value of the erythrocyte sedimentation rate, patients with CO had an advantage over SP by the number of neutrophils and monocytes, patients with PSTI relative to women with CO had reduced values of leukocyte, lymphocyte, granulocyte, erythrocyte sedimentation rate, relative to DP - monocytosis. In qualitative terms, the accumulation of hematological parameters for DP was minimal, with CO - maximum, when PSTI, SP - dynamics was average. One traditional treatment is not optimal, because it is not fully correct immune disorders. Additional administration to patients with monomodulators, metabolic agents, antioxidants, combinations of different origin, regional and systemic mechanism of action, with a differentiated focus on the basic parts of the lymphoid system (Roncoleukin, isoprinozine, gabriglobine, thymogen, nucleinate sodium, Derinat, polyoxidonium, licopid, superlymph, lipoxen, zygapan), in general, increases clinical effectiveness of conventional treatment, but requires a preliminary assessment of the effectiveness of these pharmacological effects on the clinical models. Mathematical formalization of the effects of immune disorders in the form of model formulas targets of action on lymphoid system allows you to set specific laboratory evidence to select individual options.
Effect of Multimodal Anesthesia on the Hemodynamic Profile and Acid-Base Balance in the Early Post-Operative Period in Patients Operated for Lung Tumors
Authors: Качур  , Kachur S. , Долгих  , Dolgikh V.
Published: February 2016

This work presents the effects of multimodal anesthesia with neuraxial blockade on the basic

parameters of central hemodynamics in patients operated for lung tumors, revealed by method of terapolar

rheovasography by Kubicek (systolic blood pressure, diastolic, average heart rate, ejection fraction, minute

volume of blood circulation, cardiac index, oxygen delivery index, the index of the total peripheral vascular

resistance), as well the effects on acid‐base balance of arterial blood in the immediate post‐operative period.

The level of antinociceptive protection was assessed by visual analogue scale. Comparison of results of patients

operated by means of multimodal anesthesia and the patients, operated in an inhalation intravenous

anesthesia with artificial lung ventilation and peri‐operative analgesia by opioid analgesics has revealed that

the hemodynamic profile of the first group of patients is characterized by stability of the basic parameters

such as blood pressure and heart rate, the lack of a pronounced reduction of the ejection fraction and stroke

volume of the heart, despite vasoplegia caused by epidural blockade. The level of partial oxygen tension of

arterial blood was decreased in the early postoperative period, but it was in the normal limits and he was

statistically significantly higher than in the comparison group that can help reduce the risk of post‐operative

complications. Significantly lower level of pain indicates adequate antinociceptive protection of patients.
Humoral Immune Response to Lipopolysaccharides of Enterobacteria in the Young Men 18-19 Years with Different Levels of Adaptation Reserves of Cardio-Respiratory System
Authors: Минина  , Minina E. , Гордиенко  , Gordienko A.
Published: February 2016

For the first this article time presents the data about the features of humoral immune response

to lipopolysaccharides of enterobacteria in youths with different levels of adaptation reserves, as well as the

possible pathogenetic and compensatory mechanisms of adaptive response to physical stress of sports orientation.

The analysis of correlations between cardio‐respiratory parameters and levels of serum anti‐LPS antibodies

of different classes of athletes in the competitive period and boys in the control group showed a correlation

of serum anti‐LPS‐IgA with autonomic regulation, largely expressed in students, which was accompanied

by an increase in the degree of centralization of management and regulatory mechanisms influence

the sympathetic component of the autonomic regulation. The authors demonstrate the necessity timely correction

and direction of the protective potential of the organism in relation to transient endotoxemia. After

the correction in the period between competitions increase physical performance in athletes by an average of

10.1% was accompanied by a trend towards lower levels of antibodies to enterobacterial lipopolysaccharide

classes of M and G, leveling differences in these parameters relative to boys in the control group, as well as

the lack of correlation relationships between studied parameters, indicating that the adaptive capacity expansion

with a decrease in the limiting factors.
Transcranial Electro-Psychocorrection in the Complex Treatment of Patients with Chronic Hepatitis C
Authors: Афонина  , Afonina E. , Смекалкина  , Smekalkina L.
Published: February 2016

The article presents the results of authors’ study of diagnosis and treatment of 90 patients with

chronic hepatitis C. The necessity of an organization of effective care of these patients according to combined

mental disadaptation was determined the relevance this study. Hepatitis C and its consequences are powerful

physical and mental stress on the body, occupying one of the leading causes of disability among the population.

Undetected and uncompensated timely signs of disadaptation may increase and eventually be transformed

into forms difficult to treat.

The purpose of this work was to investigate the efficacy of complex treatment of patients using the new

non‐drug technologies of psychocorrection at the stage of a hospital. For comparative analysis, the psychodiagnostic

and electro‐physiological examinations, the study of the adaptation level of and quality of life of

patients were carried out. The use of a level approach to the diagnosis of mental status of patients allows to

optimize the scheme of conventional treatment by differentiated selection of modern psycho‐methods.

The obtained data prove that the combined use of physio‐ and psychotherapy (transcranial electropsychocorrection)

is the most effective method to correct the health the health of patients with viral hepatitis

C. This method can be recommended for inclusion in the system of medical and psycho‐social support to

this contingent.
A Reconsideration of Gender Differences in Risk Attitudes
Authors: Filippin Antonio , Crosetto Paolo
Published: February 2016

This paper reconsiders the wide agreement that females are more risk averse than males. We survey the existing experimental literature, finding that significance and magnitude of gender differences are task specific. We gather data from 54 replications of the Holt and Laury risk elicitation method, involving about 7,000 subjects. Gender differences appear in less than 10% of the studies and are significant but negligible in magnitude once all the data are pooled. Results are confirmed by structural estimations, which also support a constant relative risk aversion representation of preferences. Gender differences correlate with the presence of a safe option and fixed probabilities in the elicitation method.

This paper was accepted by John List, behavioral economics.
Reputation and Regulations: Evidence from eBay
Authors: Hui Xiang , Saeedi Maryam , Shen Zeqian , Sundaresan Neel
Published: February 2016

To mitigate inefficiencies arising from asymmetric information, some markets rely on government interventions, whereas others rely on reputation systems, warranties, or guarantees. This paper explores the impact of two mechanisms, namely, reputation badges and buyer protection programs, and their interaction on eBay’s marketplace. Adding buyer protection reduces the premium for the reputation badge and increases efficiency in the marketplace. These efficiency gains are achieved by reducing moral hazard through an increase in sellers´ quality and by reducing adverse selection through a higher exit rate for low-quality sellers. Our estimates suggest buyer protection increases the total welfare by 2.9%.

This paper was accepted by Matt Shum, marketing.
Online Discrete Optimization in Social Networks in the Presence of Knightian Uncertainty
Authors: Raginsky Maxim , Nedić Angelia
Published: February 2016

We study a model of collective real-time decision making (or learning) in a social network operating in an uncertain environment, for which no a priori probabilistic model is available. Instead, the environment’s impact on the agents in the network is seen through a sequence of cost functions, revealed to the agents in a causal manner only after all the relevant actions are taken. There are two kinds of costs: individual costs incurred by each agent and local-interaction costs incurred by each agent and its neighbors in the social network. Moreover, agents have inertia: each agent has a default mixed strategy that stays fixed regardless of the state of the environment, and must expend effort to deviate from this strategy in order to respond to cost signals coming from the environment. We construct a decentralized strategy, wherein each agent selects its action based only on the costs directly affecting it and on the decisions made by its neighbors in the network. In this setting, we quantify social learning in terms of regret, which is given by the difference between the realized network performance over a given time horizon and the best performance that could have been achieved in hindsight by a fictitious centralized entity with full knowledge of the environment’s evolution. We show that our strategy achieves the regret that scales polylogarithmically with the time horizon and polynomially with the number of agents and the maximum number of neighbors of any agent in the social network.
A Two-Model Solution Approach for the Monthly Coal Train Reservations Planning Problem
Authors: Içyüz I. Ece , Richard Jean-Philippe P. , Eskigun Erdem , Acharya Dharma
Published: February 2016

The monthly coal train reservations planning problem arises in the unit train business of North American railroads. It involves a variety of operational and tactical decisions such as train formation, routing, and scheduling. As a result of the extensive scope of coal transportation in the United States, models for this problem grow quickly to a size unmanageable by state-of-the-art optimization software. Therefore, we propose a two-model heuristic solution methodology that is time-efficient and produces good quality solutions. The first model is developed under simplifying assumptions and yields an upper bound on the number of reservations to be accepted during the month. It also assigns car consists to reservations based on aggregate supply and demand of resources. This model also provides a tentative schedule for trains, and sets precedence relations between reservations. These being given, a second procedure is used to construct a detailed monthly schedule through the solution of network flow models and through the solution of a job-shop scheduling problem. The resulting solution is then improved through a large-scale neighborhood search. We evaluate our approach computationally, both on randomly generated and practical instances. We show numerically that our approach outperforms current practice.
Autistic spectrum conditions: the essentials for healthcare assistants and assistant practitioners
Authors: Wallang Paul , Elmer Dominic , Woodage Joanne
Published: February 2016

Autism can be described as ‘a lifelong developmental disability that affects how a person communicates with, and relates to, other people’ ( National Autistic Society, 2015 ).

This article seeks to give a brief overview of autism. Issues that are covered include the history of autism, its symptoms and treatments and how to work and how not to work with those who have an autistic spectrum condition.
Latest developments
Authors:   Contact a Family
Published: February 2016

Send your letters, news stories or latest developments to: The Editor, Child Care, St Jude's Church, Dulwich Road, Herne Hill, London, SE24 0PB email: childcare@markallengroup.com
Autistic spectrum disorder: what should you know?
Authors: Bellis Wendy
Published: February 2016

I am a paediatric dentist who has been working for over 20 years with the families of children who are on the autistic spectrum. This article is based not only on my own experience but also the feedback from those families whose children I have seen grow up under my care
The importance of hand hygiene
Authors: Russell Jo
Published: February 2016

This article looks at the importance of hand hygiene with regards to the initial and ongoing training required of the team in accordance with the guidance offered to us in dentistry
Performing religion: A comparative study of two interrelated Islamic practices
Authors: Arslan Ferhat
Published: February 2016

This research examines the sikiri dance of the Muslim Yao in Malawi and its contextual and performative associations with Islamic doctrines. Today the current state of sikiri is known to a certain extent, but its background still requires in-depth study. The evidence at hand, however, demonstrates that throughout history performing sikiri has caused controversies among various regional Islamic schools. This was mainly due to its accommodation of non-Islamic features, which in time have undergone some changes and, in case of the studied examples, even disappeared. Today’s sikiri dance nevertheless incorporates particular features that are reminiscent of Islamic ritual practice dhikr with respect to performance practice, form, context and embeddedness in Islam. The main aim of the research is therefore to investigate a potential kinship between present-day sikiri and dhikr in its most general sense. By doing so it also aims to draw attention to the dynamic quality of performative practices of Islam in the East African environment. The analysis is primarily based on empirical evidence that was obtained from a short fieldwork in Mangochi and Blantyre districts in Malawi.
Temporalidade e representações sociais: Estabilidade e dinâmica dos elementos ativados pelo regime militar brasileiro
Authors: Wolter Rafael Pecly , Wachelke João Fernando Rech , Sa Celso Pereira de , Dias Aline Passeri , Naiff Denis Giovani Monteiro
Published: February 2016

A abordagem estrutural das representações sociais considera que uma representação social é composta por cognemas de diferentes status: central e periférico. Todas as abordagens consideram que o fenômeno das representações é histórico e ligado à temporalidade.Parece‑nos que esta temporalidade, tanto sincrônica quanto diacrônica, pode servir como critério para distinguir os elementos centrais dos periféricos já que os primeiros são, por definição, mais estáveis que os segundos. Neste trabalho apresentamos uma pesquisa sobrea representação do Regime Militar brasileiro entre jovens (N = 295) que utilizou diferentes técnicas para distinguir os elementos centrais dos periféricos (os esquemas cognitivos de base e análise prototípica). Os resultados desta pesquisa são comparados com as pesquisas precedentes sobre o mesmo objeto. A comparação dos resultados mostra que somente três cognemas (censura, ditadura e repressão) se mantêm como centrais independentemente da técnica e do momento, o que nos leva a discutir a pertinência de comparações diacrônicas e intertécnicas para se estudar a estrutura representacional.
Determination of a space-dependent force function in the one-dimensional wave equation
Authors: Hussein S. O. , Lesnic D.
Published: February 2016

The determination of an unknown spacewice dependent force function acting on a vibrating string from over-specied Cauchy boundary data is investigated numerically using the boundary element method (BEM) combined with a regularized method of separating variables. This linear inverse problem is ill-posed since small errors in the input data cause large errors in the output force solution. Consequently, when the input data is contaminated with noise we use the Tikhonov regularization method in order to obtain a stable solution. The choice of the regularization parameter is based on the L-curve method. Numerical results show that the solution is accurate for exact data and stable for noisy data.
A New Formulation for Solutions of Boundary Value Problems Using Domain-type Approximations and Local Integral Equations
Authors: Sladek V. , Sladek J.
Published: February 2016

The boundary and domain-type approximations are discussed in boundary integral equation formulations for solution of boundary value problems. A new approach is proposed with using a domain-type approximation of the primary field and collocation of boundary conditions at boundary nodes and local integral representation of the primary field at interior nodes. Two kinds of the domain-type approximation are utilized. The proposed method is illustrated on potential problems in two dimensions.
An Advanced BEM for Thermal and Stress Analyses of Components with Thermal Barrier Coating
Authors: Lu Shan , Dong Menhong
Published: February 2016

An advanced boundary element method (BEM) for 2-D steady-state thermal analysis of components with thermal barrier coating (TBC) is presented in this paper. First, a scheme of evaluating the nearly singular integrals in stress analysis of a thin body was extended to the thermal analysis of components with TBC. Then the BEM formulation for thermal analysis of multi-layered structures was developed. Next, an advanced BEM was developed for 2-D interfacial stress analysis of components with TBC. The non-linear transformation scheme in stress analysis of thinbody under traction load by BEM was extended to evaluate the nearly singular integral in BEM for thermal and centrifugal stress analysis. Then BEM formulation for multi-layer structure under thermal, centrifugal and traction loads was presented. Several numerical examples of 2-D thermal analyses and interfacial stress analyses of components with TBC were analyzed with only 32 boundary elements. The accurate numerical results can be obtained even when the ratio of the coating thickness to element length approached 10 9 âˆ’ . The maximum relative percentage errors of interfacial tangent tension stresses under a complex temperature field, traction and centrifugal loads were 0.08%, 0.13% and 0.23%, respectively,. The present BEM will be an efficient tool for TBC design and TBC peeling-failure analysis.
Global higher integrability for non-quadratic parabolic quasi-minimizers on metric measure spaces
Authors: Fujishima Yohei , Habermann Jens
Published: February 2016

We prove up-to-the-boundary higher integrability estimates for parabolic quasi-minimizers on a domain

Ω
T

\Omega_{T}

=

=

Ω

×

\times

(0,T), where Ω denotes an open domain in a doubling metric measure space which supports a Poincaré inequality. The higher integrability for upper gradients is shown globally and under optimal conditions on the boundary

∂

\partial

Ω of the domain as well as on the boundary data itself. This is a starting point for a further discussion on parabolic quasi-minima on metric measure spaces, such as for example regularity or stability issues.
Very large solutions for the fractional Laplacian: Towards a fractional Keller–Osserman condition
Authors: Abatangelo Nicola
Published: February 2016

We look for solutions of

(

-
△

)

s

⁢
u

+

f
⁢

(
u
)

=
0

{{\left(-\triangle\right)}^{s}u+f(u)=0}

in a bounded smooth domain Ω,

s
∈

(
0
,
1
)

{s\in(0,1)}

,
with a strong singularity at the boundary.
In particular, we are interested in solutions which are

L
1

⁢

(
Ω
)

{L^{1}(\Omega)}

and higher order
with respect to

dist

(
x
,
∂
Ω
)

s
-
1

{\operatorname{dist}(x,\partial\Omega)^{s-1}}

. We provide
sufficient conditions for the existence of such a solution.
Roughly speaking, these functions are the real fractional counterpart
of large solutions in the classical setting.
Red clover (Trifolium pratense L.) honey: volatiles chemical-profiling and unlocking antioxidant and anticorrosion capacity
Authors: Jerković Igor , Radonić Ani , Kranjac Marina , Zekić Marina , Marijanović Zvonimir , Gudićc Senka , Kliškić Maja
Published: February 2016

Headspace solid-phase micro-extraction (HS-SPME) and ultrasonic solvent extraction (USE) were used for red clover honey volatiles extraction. The extracts were analysed using gas chromatography and mass spectrometry (GC-MS). Lilac aldehyde isomers dominated in the headspace (individual range from 7.6 % to 21.4 %) followed by phenylacetaldehyde (10.1-31.2 %) and benzaldehyde (7.0-15.7 %). Higher aliphatic alcohols and hydrocarbons were the predominant constituents of the honey extracts. The honey and its extracts exhibited rather weak anti-radical activity (DPPH assay) and total antioxidant activity (FRAP assay). On the other hand, the honey’s inhibitive properties towards the corrosion of AA 2017A alloy in NaCl solution (potentiodynamic polarisation and potentiostatic pulse measurements) revealed the honey to be a very good anodic inhibitor (efficiency up to 76 %) while the honey extracts (USE) showed better inhibition efficacy.
Deck and Cable Dynamic Testing of a Single-span Bridge Using Radar Interferometry and Videometry Measurements
Authors: Piniotis George , Gikas Vassilis , Mpimis Thanassis , Perakis Harris
Published: February 2016

This paper presents the dynamic testing of a roadway, single-span, cable-stayed bridge for a sequence of static load and ambient vibration monitoring scenarios. Deck movements were captured along both sideways of the bridge using a Digital Image Correlation (DIC) and a Ground-based Microwave Interfererometer (GBMI) system. Cable vibrations were measured at a single point location on each of the six cables using the GBMI technique.

Dynamic testing involves three types of analyses; firstly, vibration analysis and modal parameter estimation (i. e., natural frequencies and modal shapes) of the deck using the combined DIC and GBMI measurements. Secondly, dynamic testing of the cables is performed through vibration analysis and experimental computation of their tension forces. Thirdly, the mechanism of cable-deck dynamic interaction is studied through their Power Spectra Density (PSD) and the Short Time Fourier Transform (STFT) analyses. Thereby, the global (deck and cable) and local (either deck or cable) bridge modes are identified, serving a concrete benchmark of the current state of the bridge for studying the evolution of its structural performance in the future. The level of synergy and complementarity between the GBMI and DIC techniques for bridge monitoring is also examined and assessed.
The Sure-Thing Principle
Authors: Pearl Judea
Published: February 2016

In 1954, Jim Savage introduced the Sure Thing Principle to demonstrate that preferences among actions could constitute an axiomatic basis for a Bayesian foundation of statistical inference. Here, we trace the history of the principle, discuss some of its nuances, and evaluate its significance in the light of modern understanding of causal reasoning.
Crystal structure of bis(2-fluoro-4-nitrophenyl) terephthalate C20H10F2N2O8
Authors: Chen Wei , Ji Mian , Yang Shiyong
Published: February 2016

C20H10F2N2O8, triclinic, P1̅, a = 9.0557(19) Å, b = 9.2766(17) Å, c = 12.641(3) Å, α = 109.115(11)°, β = 97.058(11)°, γ = 108.767(11)°, V = 918.6(3) Å3, Z = 2, R
gt(F) = 0.0537, wR
ref(F
2) = 0.1416, T = 173 K.
Erfolgsfaktoren im Management von Komplementärwährungsorganisationen
Authors: Martignoni Jens , Gmür Markus
Published: February 2016

Komplementärwährungsorganisationen betreiben Währungssysteme in privater Trägerschaft, die zum Leistungstausch zwischen Personen oder Körperschaften geschaffen wurden. Sie haben für die Mitglieder einen ausgeprägten Selbsthilfecharakter, indem sie den Wettbewerb auf ein mehr oder weniger enges Feld eingrenzen. In einer Untersuchung von 15 Organisationen aus dem deutschsprachigen Raum wurde der Zusammenhang zwischen einer Reihe von Zielerreichungskriterien und dem Entwicklungsgrad des Management- Systems (in Anlehnung an das Freiburger Management-Modell für NPO) untersucht. Es zeigte sich, dass Organisationen, welche von Beginn an ein höher entwickeltes Management- System institutionalisieren, länger und gemessen am Währungsumsatz erfolgreicher sind.
Mitglieder-Bonussysteme als Instrument zur Erfüllung des Förderauftrags in Kreditgenossenschaften
Authors: Diel Annika , Klaus Johannes , Doluschitz Reiner
Published: February 2016

Die Analyse von Mitglieder-Bonussystemen in Kreditgenossenschaften zeigt, dass diese Systeme eine Komponente der Mitgliederförderung sein können. Gerade Leistungsaustauschbeziehungen zwischen Mitglied und Bank können hiermit gefördert werden, was zu einer Aktivierung der Mitgliedschaft führen kann. Ein geeignetes Instrument zur Differenzierung im Bankenwettbewerb stellt ein Mitglieder-Bonussystem jedoch nur bedingt dar. Vielmehr müssen individuell zugeschnittene Systeme angeboten werden, was wiederum einen hinreichend modularen Aufbau voraussetzt. Zudem muss die Mitgliedschaft gezielt in die Strategie von Genossenschaftsbanken eingebunden sein. Die bankenindividuelle Mitgliederstruktur ist ebenfalls zu beachten.
Gesellschaftliche Verantwortung von Genossenschaften durch MemberValue-Strategien
Authors: Theurl Theresia
Published: February 2016

Genossenschaftliche Kooperationen weisen eine besondere Governance auf. Strikt einzelwirtschaftlich motiviert entstehen zusätzlich positive gesellschaftliche und gesamtwirtschaftliche Effekte, die aus der genossenschaftlichen Zusammenarbeit folgen und die nicht ex post durch eine freiwillige oder erzwungene Korrektur der unternehmerischen Ergebnisse erreicht werden. Der MemberValue-Strategie als dem adäquaten genossenschaftlichen Steuerungskonzept ist die Übernahme gesellschaftlicher Verantwortung inhärent.
Institutionelle Lösungen bei der Mikrokreditvergabe – Empirische Befunde aus Österreich
Authors: Rimpler Melanie
Published: February 2016

Mikrokredite können eine Unternehmensgründung erleichtern helfen - nicht nur in Schwellen- undEntwicklungsländern.Der Beitrag beschreibt sozial- undwirtschaftspolitische Mikrokredit-Förderprogramme in Österreich mit ihren Initiatoren. Sehr oft unterstützen verschiedene öffentliche und private Partner zusammen mit Kreditinstituten eine Kreditvergabe, sei es bei der Beratung und Auswahl, durch Kapital, Sonderkonditionen oder Ausfallshaftungen. Auch wenn in Europa derzeit solidarische Formen der Kreditsuchenden weniger ausgeprägt sind, zeigen doch Kooperationen auf institutioneller Ebene weiterhin vorhandenes Vertrauen in das Potenzial von kooperativen Lösungen.
Eigenkapitalmanagement in Kreditgenossenschaften unter besonderer Berücksichtigung der möglichen Auswirkungen von Basel III
Authors: Reifschneider Annika
Published: February 2016

Als Konsequenz aus der schweren Finanzmarktkrise verfolgen die neu bekannt gegebenen Kapital- und Liquiditätsrichtlinien das Ziel, eine bessere Balance zwischen den eingegangenen Risiken und dem vorhandenen Eigenkapital der Banken zu schaffen. Aufgrund ihrer besonderen Werte und ihrer speziellen Governancestruktur fordern die Kreditgenossenschaften eine rechtsformabhängige Differenzierung der Gesetze. Mittels einer empirischen Untersuchung unter Genossenschaftsbanken wurden vor Inkrafttre­ten des Rahmenwerks Basel III verschiedene Handlungsoptionen identifiziert und analysiert. Basel III beinhaltet für die Genossenschaftsbanken einige Herausforderungen, stellt für den Großteil der Kreditgenossenschaften jedoch keine existentielle Bedrohung dar.
Überlegungen zur Regulierung erfolgsbasierter Vergütungssysteme in Genossenschaftsbanken
Authors: Bader David , Baumüller Josef
Published: February 2016

Genossenschaftsbanken sind seit dem Ausbruch der Finanzkrise von besonders umfassenden Regulierung(sbestrebung)en betroffen. Ein Schwerpunkt liegt hierbei auf den eingerichteten Vergütungssystemen; die Vorgaben erstrecken sich gleichsam über deren Ausgestaltung wie die Berichterstattung über diese. Eine Gegenüberstellung dieser Regulierung mit den genossenschaftlichen Spezifika hinsichtlich Governance-Fragen und daraus abgeleiteten Einsatzbedingungen erfolgsbasierter Vergütungssysteme zeigt hier jedoch ins Leere gehende Bestimmungen bzw. unbeantwortete Fragen. Die zweckmäßige Ausgestaltung erfolgsbasierter Vergütungssysteme im Genossenschaftskontext erfordert ein hohes Maß an konzeptioneller Sorgfalt und kann nicht unmittelbar aus dem Rahmen für börsennotierte Unternehmen abgeleitet werden.
ZfgG-Kurzbeitrag: Neckenmarkt oder Mühldorf, wo lag die erste Raiffeisenkasse im heutigen Österreich?
Authors: Werner Wolfgang
Published: February 2016

Seit dem Erscheinen der Festschrift „90 Jahre Raiffeisen Burgenland, 1922 - 2012“ im Jahre 2013 gibt es Unklarheit über die erste Gründung einer Raiffeisenkasse imheutigen Österreich. Die Festschrift nennt das im ehemaligen Königreich Ungarn der Doppelmonarchie gelegene Neckenmarkt/Westungarn als erste Gründung, bereits 1878 errichtet. Eine Analyse der vorliegenden Informationen bestätigt aber die immer getätigte Aussage, dass die erste Gründung 1886 inMühldorf bei Spitz in Niederösterreich erfolgte.
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides
Authors: Cawley Niamh X , Li Zhaojin , Loh Y Peng
Published: February 2016

Pro-opiomelanocortin (POMC) is a prohormone that encodes multiple smaller peptide hormones within its structure. These peptide hormones can be generated by cleavage of POMC at basic residue cleavage sites by prohormone-converting enzymes in the regulated secretory pathway (RSP) of POMC-synthesizing endocrine cells and neurons. The peptides are stored inside the cells in dense-core secretory granules until released in a stimulus-dependent manner. The complexity of the regulation of the biosynthesis, trafficking, and secretion of POMC and its peptides reflects an impressive level of control over many factors involved in the ultimate role of POMC-expressing cells, that is, to produce a range of different biologically active peptide hormones ready for action when signaled by the body. From the discovery of POMC as the precursor to adrenocorticotropic hormone (ACTH) and β-lipotropin in the late 1970s to our current knowledge, the understanding of POMC physiology remains a monumental body of work that has provided insight into many aspects of molecular endocrinology. In this article, we describe the intracellular trafficking of POMC in endocrine cells, its sorting into dense-core secretory granules and transport of these granules to the RSP. Additionally, we review the enzymes involved in the maturation of POMC to its various peptides and the mechanisms involved in the differential processing of POMC in different cell types. Finally, we highlight studies pertaining to the regulation of ACTH secretion in the anterior and intermediate pituitary and POMC neurons of the hypothalamus.
Negative Zinsen bei Darlehensverträgen?
Authors: Söbbing Thomas , von Bodungen Benjamin
Published: February 2016

Angesichts der aktuellen Niedrigzinsphase (beispielsweise hat die japanische Notenbank jüngst am 29. 1. 2016 die Einführung eines negativen Einlagenzinssatzes von 0,1 % beschlossen) stellt sich die Frage, ob Darlehensverträge, die für die Zinshöhe an einen Referenzzinssatz (wie den EURIBOR) anknüpfen und damit eine variable Verzinsung vorsehen, zu negativen Zinsen führen können, mit denen der Kapitalgeber belastet wird. Diese Frage wird insbesondere auch bei Bestandsverträgen virulent, wenn der von einer Zinsgleitklausel spezifizierte Referenzzinssatz im Laufe der Vertragszeit so weit in den negativen Bereich fällt, dass dadurch der Darlehenszinssatz insgesamt negativ wird, ohne dass insoweit ein vertraglicher Korrekturmechanismus vorgesehen ist. Da dieser Fall im europäischen Wirtschaftsraum völlig neu ist, stellt sich die Frage nach der Wirksamkeit einer solchen automatischen Zinsänderung mit besonderer Dringlichkeit.
KEBERSAMAAN DALAM PERBEDAAN: STUDI KASUS MASYARAKAT CIGUGUR, KABUPATEN KUNINGAN, JAWA BARAT
Authors: Syaripulloh Syaripulloh
Published: February 2016

This study was conducted to gain an overview of togetherness and harmony in the life of a multi-religious society Cigugur. The study was conducted using descriptive-qualitative methods deskriktif, with the observation, in-depth interviews, and documentation study as data collection techniques. The results showed that  Cigugur people who have a diversity in religion, namely Islam, Christianity, Catholicism, Protestantism, Aga ma Djawa Sunda (ADS) can coexist peacefully. They can live together respectfully because they have strong blood ties. For the people together is more important than the divisions caused by differing views. The unifying fac tor is the chairman of each religion, in addition to the prominent role of Pangeran Djatikusumah as Madrais descent.As the dominant culture, Agama Djawa Sunda (ADS) implement a full tolerance for Cigugur society to embrace and practice religious.
PENDIDIKAN BAGI PENDATANG DI TENGAH MAYORITAS MASYARAKAT PRIBUMI
Authors: Hermawan Iwan
Published: February 2016

This article is concerned with the conception of education for immigrants in the middle of the indigenous majority. As it is known that the movement of people from one place to another is a common and this effect on people’s lives, both migrants and natives. These conditions further reinforce the diversity of Indon esian society and encourage the need for multicultural education. Feature of the present time that every student h as the same rights in acquiring cultural knowledge and educational process is to be developed to further highlig ht the cultural diversity that supports the idea of mutual respect for differences among people. Meanwhile, the introduction of the values of the dominant culture of the local community needs to be done as the basis for a process of interaction and adaptation processes in a common life in the community.
PENGARUH PENDIDIKAN TERHADAP PENDAPATAN DOMESTIK REGIONAL BRUTO DI INDONESIA
Authors: Al Arif M. Nur Rianto
Published: February 2016

The aim of this research is to analyze the influence of education on gross domestic regional product at 33 provinces in Indonesia. The analysis method that used in this research is multiple regressions with six independent variables such as literacy rate, years of school, enrolment rate 1, enrolment rate 2, enrolment rate 3, and population. The result shown that years of school and population had an influence on gross domestic regional product in Indonesia, and literacy rate, enrolment rate 1, enrolment rate 2, and enrolment rate 3 didn’t have an influence of gross domestic regional product. From this result we can conclude that overall education had an impact on growth in IndonesiaDOI: 10.15408/sjie.v3i1.2062