bluuebunny/crossref_metadata_2025 huggingface dataset:
The frozen elephant trunk technique for acute retrograde type A aortic dissection: preliminary results
Authors: Kaneyuki Daisuke , Mogi Kenji , Watanabe Hiroyuki , Otsu Masayoshi , Sakurai Manabu , Takahara Yoshiharu
Published: August 2020

OBJECTIVES

Our goal was to determine the early and midterm outcomes after total arch replacement with the frozen elephant trunk (FET) technique compared to those of the conventional elephant trunk (ET) technique for acute retrograde type A aortic dissection.

METHODS

Between 2012 and 2019, a total of 49 patients had total arch replacement for acute retrograde type A aortic dissection. Patients were divided into the conventional ET (n = 17) and FET (n = 32) groups. The false lumen status was evaluated using enhanced computed tomography (CT) 1 week postoperatively. The diameter of the downstream aorta was evaluated annually using CT. The median follow-up period was 29 months.

RESULTS

Preoperative data and neurological complications were not significantly different in the 2 groups. The diameter and length of the ET prosthesis were significantly larger and longer in the FET group. The overall early mortality rate was 10.2% (5/49) with no differences between the 2 groups. The mean follow-up period was significantly longer in the conventional ET group. The rates of freedom from aortic events at 3 years were significantly lower in the FET group. At the level of the distal arch, postoperative false lumen patency was significantly lower and the follow-up aortic diameter was significantly smaller in the FET group.

CONCLUSIONS

The FET technique facilitates false lumen thrombosis and aortic remodelling at the distal arch level, with fewer adverse aortic events during the follow-up period with acceptable early outcomes; however, these findings are exploratory and require investigation.
Inter-mortality displacement hypothesis and short-term effect of ambient air pollution on mortality in seven major cities of South Korea: a time-series analysis
Authors: Kim Honghyok , Lee Jong-Tae
Published: August 2020

Background

Inter-mortality displacement (IMD) between cause-specific mortalities has not been introduced in air pollution epidemiology. Investigation into IMD would provide insights on the actual health burden of air pollution and interpretation of associations. We aimed to investigate IMD regarding short-term effect of air pollution on mortality.

Methods

We illustrated manifestations and interpretations of lag-mortality associations. If IMD exists, a net increase of one cause-specific death can be offset by a net decrease of other cause-specific deaths. We conducted a time-series analysis to estimate associations of ambient particulate matter smaller than 10 µm (PM10), ozone (O3), sulphur dioxide (SO2), nitrogen dioxide (NO2) and carbon monoxide (CO) with mortality, considering lags up to the previous 45 days, for seven major cities of South Korea from 2006 to 2013. Attributable mortality cases were identified.

Results

For O3, respiratory mortality [11 929 cases, 95% empirical confidence interval (eCI), 5358, 17 688 cases] was counterbalanced by cardiovascular mortality (-11 272 cases, 95% eCI: -22 444, -629 cases). All-cause mortality was 37 148 cases (95% eCI: 4448, 68 782 cases). For PM10, respiratory deaths were 9167 cases (95% eCI: 563, 16 521 cases), and cardiovascular deaths were 6929 cases (95% eCI: -11 793, 24 138 cases). Estimates for SO2 were comparable to those for PM10. All-cause mortality attributable to NO2 was explained by short-term mortality displacement. No associations with mortality were found for CO.

Conclusions

IMD may exist in the relationship between air pollution and mortality. The actual relationship between air pollution and cause-specific mortality may be masked by IMD.
Cohorts as collections of bodies and communities of persons: insights from the SEARCH010/RV254 research cohort
Authors: Henderson Gail E , Rennie Stuart , Corneli Amy , Peay Holly L
Published: August 2020

Longitudinal research cohorts are uniquely suited to answer research questions about morbidity and mortality. Cohorts may be comprised of individuals identified by specific conditions or other shared traits. We argue that research cohorts are more than simply aggregations of individuals and their associated data to meet research objectives. They are social communities comprised of members, investigators and organizations whose own interests, identities and cultures interact and evolve over time. The literature describes a range of scientific and ethical challenges and opportunities associated with cohorts. To advance these deliberations, we report examples from the literature and our own research on the Thai SEARCH010/RV254 cohort, comprising individuals diagnosed with human immunodeficiency virus (HIV) during acute infection. We reflect on the impact of cohort experiences and identity, and specifically how people incorporate cohort participation into meaning making associated with their diagnosis, the influence of cohort participation on decision making for early-phase clinical trials recruited from within the cohort, and the impact of the relationships that exist between researchers and participants. These data support the concept of cohorts as communities of persons, where identity is shaped, in part, through cohort experiences. The social meanings associated with cohorts have implications for the ethics of cohort-based research, as social contexts inevitably affect the ways that ethical concerns manifest.
Revising Ferritin Lower Limits: It’s Time to Raise the Bar on Iron Deficiency
Authors: Parker Michelle L , Storm Sherri , Sholzberg Michelle , Yip Paul M , Beriault Daniel R
Published: August 2020

Ferritin is a key diagnostic marker of iron deficiency (ID), but the interpretative guidance provided to physicians varies significantly. Clear discrepancies exist between clinical guidelines that recommend evidence-based ferritin cutoffs and clinical laboratories that report highly variable ferritin reference intervals (RIs) derived from apparently healthy populations. In this study, clinical laboratories across North America were surveyed to assess the RIs provided with ferritin results. Although clinical guidelines often recommend ferritin cutoffs of 15 or 30 µg/L to identify uncomplicated ID, the survey showed that 18 of 23 responding laboratories reported female RI lower limits well below 15 µg/L. To understand the clinical impact, we analyzed 52 027 unique patient ferritin values over a 5-year period (2013–2017) from a tertiary care hospital. In this population, the 90th percentile ferritin cutoff to identify ID anemia in adults was 24 µg/L in female patients and 25 µg/L in male patients. Distribution of ferritin results in female patients showed that menopausal status had a significant effect on median values, which increased 2- to 3-fold in the postmenopausal state. Furthermore, sorting the data for female patients by physician specialty showed the highest prevalence of low ferritin values in patients seen in obstetrics and gynecology. This study highlights the discrepancy between clinical guidelines and clinical laboratory practice for ferritin reporting and indicates that ferritin RIs, particularly for female patients, are set to an inappropriately low threshold in most clinical laboratories in North America; this level provides good specificity but poor sensitivity when screening for ID.
Non-Destructive Measurement of the Internal Quality of Citrus Fruits Using a Portable NIR Device
Authors: Santos Carla S P , Cruz Rebeca , Gonçalves Diogo B , Queirós Rafael , Bloore Mark , Kovács Zoltán , Hoffmann Isabel , Casal Susana
Published: August 2020

The citrus industry has grown exponentially as a result of increasing demand on its consumption, giving it high standing among other fruit crops. Therefore, the citrus sector seeks rapid, easy, and non-destructive approaches to evaluate in real time and in situ the external and internal changes in physical and nutritional quality at any stage of fruit development or storage. In particular, vitamin C is among the most important micronutrients for consumers, but its measurement relies on laborious analytical methodologies. In this study, a portable near infrared spectroscopy (NIRS) sensor was used in combination with chemometrics to develop robust and accurate models to study the ripeness of several citrus fruits (oranges, lemons, clementines, tangerines, and Tahiti limes) and their vitamin C content. Ascorbic acid, dehydroascorbic acid, and total vitamin C were determined by HILIC-HPLC-UV, while soluble solids and total acidity were evaluated by standard analytical procedures. Partial least squares regression (PLSR) was used to build regression models which revealed suitable performance regarding the prediction of quality and ripeness parameters in all tested fruits. Models for ascorbic acid, dehydroascorbic acid, total vitamin C, soluble solids, total acidity, and juiciness showed Rcv2 = 0.77–0.87, Rcv2 = 0.29–0.79, Rcv2 = 0.77–0.86, Rcv2 = 0.75–0.97, Rcv2 = 0.24–0.92, and Rcv2 = 0.38–0.75, respectively. Prediction models of oranges and Tahiti limes showed good to excellent performance regarding all tested conditions. The resulting models confirmed that NIRS technology is a time- and cost-effective approach for predicting citrus fruit quality, which can easily be used by the various stakeholders from the citrus industry.
Comparison of the gut microbiota in the groundwater amphipod Crangonyx islandicus Svavarsson & Kristjánsson, 2006 (Amphipoda: Crangonyctidae) to biofilms in its spring-source habitat
Authors: Gudmundsdóttir Ragnhildur , Björnsdóttir Snædís H , Marteinsson Viggó Þ , Pálsson Snæbjörn
Published: August 2020

Crangonyx islandicus Svavarsson & Kristjánsson, 2006 is a groundwater amphipod endemic to Iceland and restricted to spring sources at edges of lava fields in the volcanically active zone. Genetic analysis indicate that the amphipod has survived in subglacial refugia in the groundwater in Iceland during past Ice Ages. We investigated the gut bacteria of C. islandicus and compared them with the bacterial diversity identified in biofilms from its groundwater habitat. The diversity of both uncultivated and cultivated bacteria was analyzed using partial 16S rRNA gene sequences. The results show that iron-oxidizing bacteria such as Sideroxydans and Gallionella and the methanotroph Methylobacter are common in the biofilm but absent from the gut samples. Thiomonas was common in both the biofilm and the gut samples. The cultivation of gut bacteria revealed that most of the taxa could be linked with terrestrial soil and/or freshwater habitat based on available database entries. This indicates that the food source for the amphipods is partly of terrestrial origin. The presence of primary producers in the subsurface habitat of C. islandicus indicate that microbial chemolithotrophic activity might fuel the system at least partly and thus explain the amphipod survival in the subsurface of Iceland during repeated glaciation for the past 5 mya.
Adjuvant and neoadjuvant therapy for biliary tract cancer: a review of clinical trials
Authors: Nara Satoshi , Esaki Minoru , Ban Daisuke , Takamoto Takeshi , Shimada Kazuaki , Ioka Tatsuya , Okusaka Takuji , Ishii Hiroshi , Furuse Junji
Published: August 2020

Cancer originating in the biliary tract can be classified as bile duct cancer (cholangiocarcinoma), gallbladder cancer, or ampullary cancer. Bile duct cancer is further divided to intrahepatic, perihilar and distal bile duct subtypes according to the anatomical location of the tumor. The biological characteristics of each tumor are heterogeneous. However, because of the rarity of each disease, the efficacy of new drugs has been tested in groups of patients with different biliary tract cancers. In patients with metastatic or recurrent biliary tract cancer, recent randomized clinical trials revealed the non-inferiority of gemcitabine + S-1 and the superiority of gemcitabine + cisplatin + S-1 compared with gemcitabine + cisplatin in terms of overall survival, thereby establishing a new standard treatment. In the field of adjuvant therapy for biliary tract cancer, the British BILCAP (capecitabine compared with observation in resected biliary tract cancer) study revealed longer median overall survival in the capecitabine group than in the observation group in the per-protocol analysis (but not in the intention-to-treat analysis), bringing a shift toward postoperative management. Several other studies of adjuvant therapy are ongoing, and they may lead to reforms in treatment strategy for resectable biliary tract cancer in the future. The use of neoadjuvant therapy for biliary tract cancer is in its infancy, but it is expected to overcome the limitations of adjuvant therapy for this malignancy. In this review, we summarized the evidence available from clinical trials of adjuvant and neoadjuvant therapy for biliary tract cancer and described ongoing clinical trials.
The decoupling between gas exchange and water potential ofCinnamomum camphoraseedlings during drought recovery and its relation to ABA accumulation in leaves
Authors: Duan Honglang , Wang Defu , Wei Xiaohua , Huang Guomin , Fan Houbao , Zhou Shuangxi , Wu Jianping , Liu Wenfei , Tissue David T , Wan Songze
Published: August 2020

Aims

Drought stress and the degree of drought severity are predicted to rise under highly variable patterns of precipitation due to climate change, while the capacity of trees to cope with drought recovery through physiological and biochemical adjustment remains unclear. We aimed to examine the coupling of physiology and biochemistry in trees during drought and the following recovery.

Methods

Potted seedlings of Cinnamomum camphora were grown under well watered conditions prior to the experimental drought stress, which was initiated by withholding water. Seedlings were rewatered following attainment of two drought severities: mild drought (stomatal closure) and moderate drought (ψxylem = −1.5 MPa). We measured leaf-level water potential, gas exchange (photosynthesis and stomatal conductance), abscisic acid (ABA), proline and non-structural carbohydrates (NSCs) concentrations in seedlings of C. camphora during drought and a 4-day recovery.

Important Findings

We found that drought severity largely determined physiological and biochemical responses and affected the rate of recovery. Stomatal closure occurred at the mild drought stress, accompanied with ABA accumulation in leaves and decline in water potential, while leaf proline accumulation and variable NSC were evident at the moderate drought stress. More severe drought stress led to delayed recovery of gas exchange, but it did not have significant effect on water potential recovery. The relationships of water potential and gas exchange differed during drought stress and post-drought recovery. There was tight coupling between water potential and gas exchange during drought, but not during rewatering due to high ABA accumulation in leaves, thereby delaying recovery of stomatal conductance. Our results demonstrate that ABA could be an important factor in delaying the recovery of stomatal conductance following rewatering and after water potential recovery of C. camphora. Furthermore, greater drought severity had significant impacts on the rate of recovery of tree physiology and biochemistry.
Ecophysiological responses of two poplar species to intraspecific and interspecific competition under different nitrogen levels
Authors: Li Yan , Kang Jieyu , Li Zhijun , Korpelainen Helena , Li Chunyang
Published: August 2020

Aims

Populus deltoides and P. euramericana are widely used in China as major forestry species. At present, little is known about their responses to nitrogen (N) deficiency when grown in monocultures or mixed plantations. The aim of this investigation was to analyze the growth, and morphological and physiological responses of P. deltoides and P. euramericana to different N levels under competition conditions.

Methods

We employed two Populus species (P. deltoides and P. euramericana) to discover how N deficiency affects plant traits under different competition types (P. deltoides × P. deltoides, intraspecific competition; P. euramericana × P. euramericana, intraspecific competition; P. deltoides × P. euramericana, interspecific competition). Potted seedlings were exposed to two N levels (normal N, N deficiency), and nitrogen- and competition-driven differences in growth, morphology and physiology were examined.

Important Findings

Under normal N conditions, interspecific competition significantly decreased the total root weight, root mass fraction (RMF), root–shoot ratio (R/S) and carbon/nitrogen ratio (C/N), and increased the leaf dry weight, leaf mass fraction and total leaf area of P. euramericana compared with intraspecific competition. The same conditions significantly affected the growth and morphological variables of P. deltoides, except for the dry weight of fine roots, R/S, specific leaf area, RMF, total nitrogen content and C/N compared with intraspecific competition. In addition, chlorophyll a (Chla), total chlorophyll (Tchl), carotenoid contents (Caro) and the carbon isotope composition (δ 13C) of P. deltoides were significantly lower in interspecific competition than in intraspecific competition, but no difference was detected in P. euramericana. The effects of N deficiency on P. deltoides under intraspecific competition were stronger than under interspecific competition. In contrast, the effects of N deficiency on P. euramericana between intraspecific and interspecific competition were not significantly different. These results suggest that under normal N condition, P. deltoides is expected to gain an advantage in monocultures rather than in mixtures with P. euramericana. Under N deficiency, the growth performance of P. euramericana was more stable than that of P. deltoides under both cultivation modes.
Gibberellin-mediated RGA-LIKE1 degradation regulates embryo sac development in Arabidopsis
Authors: Gomez Maria Dolores , Barro-Trastoy Daniela , Fuster-Almunia Clara , Tornero Pablo , Alonso Jose M , Perez-Amador Miguel A
Published: August 2020

Ovule development is essential for plant survival, as it allows correct embryo and seed development upon fertilization. The female gametophyte is formed in the central area of the nucellus during ovule development, in a complex developmental programme that involves key regulatory genes and the plant hormones auxins and brassinosteroids. Here we provide novel evidence of the role of gibberellins (GAs) in the control of megagametogenesis and embryo sac development, via the GA-dependent degradation of RGA-LIKE1 (RGL1) in the ovule primordia. YPet-rgl1Δ17 plants, which express a dominant version of RGL1, showed reduced fertility, mainly due to altered embryo sac formation that varied from partial to total ablation. YPet-rgl1Δ17 ovules followed normal development of the megaspore mother cell, meiosis, and formation of the functional megaspore, but YPet-rgl1Δ17 plants had impaired mitotic divisions of the functional megaspore. This phenotype is RGL1-specific, as it is not observed in any other dominant mutants of the DELLA proteins. Expression analysis of YPet-rgl1Δ17 coupled to in situ localization of bioactive GAs in ovule primordia led us to propose a mechanism of GA-mediated RGL1 degradation that allows proper embryo sac development. Taken together, our data unravel a novel specific role of GAs in the control of female gametophyte development.
The Association Between Serum Human Epididymis Protein 4 Level and Cardiovascular Events in Patients with Chronic Obstructive Pulmonary Disease
Authors: Lin Hui , Xiao Jianhong , Su Xianghua , Song Bin
Published: August 2020

Objective

Serum human epididymis protein 4 (HE4) is associated with immune and inflammatory responses. This study aimed to assess the performance of serum HE4 in the early detection of cardiovascular (CV) events in patients with chronic obstructive pulmonary disease (COPD).

Methods

Serum HE4 levels were measured in 199 patients with COPD, all of whom were prospectively followed up for a median period of 36 months (range = 3 months–38 months). Logistic regression analysis was performed to assess the association between cardiovascular disease (CVD) history and HE4 in patients with COPD. Cox proportional hazard analysis was performed to assess the prognostic value of serum HE4 for predicting CV events.

Results

Serum HE4 levels were higher in patients with COPD with CV events than in those without CV events (252.6 pmol/L [186.4–366.8] vs 111.0 pmol/L [84.8–157.1]; P <.001). The multivariate logistic regression model revealed that serum HE4 (odds ratio = 1.639; 95% confidence interval [CI], 1.213–2.317; Ptrend =.009) was independently associated with CVD history after adjusting for age, sex, body mass index, current smoking status, current alcohol consumption status, admission systolic blood pressure and diastolic blood pressure, hyperlipidemia, left ventricular ejection fraction, primary diseases, and laboratory measurements in patients with COPD at baseline. The multivariate Cox proportional hazard analysis revealed that serum HE4 (hazard ratio = 2.012; 95% CI, 1.773–4.469; P <.001) was an independent prognostic factor for CV events in these patients. The Kaplan-Meier analysis showed that the rate of CV events was higher in patients with COPD with HE4 levels above the median (187.5 pmol/L) than in those with HE4 levels below the median.

Conclusion

Our results showed that serum HE4 was significantly and independently associated with CVD history and had independent predictive value for CV events in patients with COPD. Serum HE4 may enable early recognition of CV complication development among patients with COPD.
Ruptured Abdominal Aortic Aneurysm Presenting as Septic Shock
Authors: Davis Bryon , Brockshus Aaron , Merritt Clay , Donaldson Chase
Published: August 2020

A patient presented to the emergency department with undifferentiated shock 4 days after discharge from a hospitalization for a lower gastrointestinal bleed. The patient fulfilled 4/4 of the Systemic Inflammatory Response Syndrome criteria and 3/3 of the quick Sequential Organ Failure Assessment criteria on presentation to the emergency department, notably, without a localized source of infection and no localizing symptoms. After admission, the patient’s hemoglobin was found to have dropped more than expected after intravenous (IV) fluid administration, suggesting a potential alternative or concurrent etiology of the patient’s shock state. A digital rectal and focused assessment with sonography in trauma exam were performed and negative. The patient was then diagnosed with a ruptured infrarenal abdominal aortic aneurysm contained in the retroperitoneum by repeat point-of-care ultrasound. The patient was hemodynamically stabilized and taken for emergent grafting without confirmatory imaging. The patient was later found to also have 4/4 blood cultures positive with methicillin-sensitive Staphylococcus aureus associated with an aortic valvular vegetation and a mycotic aneurysm which contributed to the abdominal aortic aneurysm rupture. This case supports the use of comprehensive point-of-care ultrasound imaging to more rapidly and more definitively differentiate types of shock and etiologies of a shock state which can lead to more timely changes in management and improvement in outcomes.
Expeditionary Immersion Circulating Heating Device: A Promising Technique for Treating Frostbite Injuries and Warming Intravenous Fluids in a Forward Deployed Cold Weather Environment
Authors: Vinceslio Eric M , Fayos Zane , Bernadette Aaron , Van Gent Jan-Michael
Published: August 2020

Introduction

Cold weather injuries require prompt warm water immersion therapy, which proves to be a difficult task in the cold austere environment. Current guidelines recommend 104 °F water immersion, but producing and maintaining large volumes of warm water is challenging in sub-freezing temperatures. We describe a novel process of utilizing a sous vide immersion circulator to maintain warm fluids for immersion therapy and efficient fluid rewarming in a cold forward-deployed setting for the treatment of cold weather injuries in an effort to bridge the gap between current medical guidelines and practices.

Materials and Methods

Large water cans were warmed to 104 °F with the immersion circulator. A thermometer was inserted into a 1-inch steak, frozen to 30 °F, and placed in a basin with only the warmed water while the internal temperature was monitored until physiologic temperature was achieved. The time to this endpoint was recorded. A 1-L bag of normal saline and a 450-mL bag of whole blood were also separately warmed by the same technique. The temperature of the normal saline was monitored at 0-, 5-, 7-, 8-, 9-, and 10 -minute intervals. The process was similarly repeated, measuring the whole blood temperature at 0-, 5-, 7-, and 10-minute intervals.

Results

Ambient internal tent temperatures averaged 54 °F; outdoor temperatures were consistently sub-freezing. The 5-gallon cans of water at ambient temperature heated to 104 °F in 15 minutes. The water temperature remained constant for 3 weeks with the circulator running. The frozen steak started at 30 °F and reached 98 °F in 52 minutes and 45 seconds. The bag of normal saline and whole blood, refrigerated to 39 °F, achieved temperatures of 102 °F and 94 °F respectively after 10 minutes.

Conclusion

A heating immersion circulator device is a lightweight, flameless, and inexpensive way to consistently heat large volumes of water for treatment of cold weather injuries, hypothermia, and whole blood rewarming in a cold austere environment.
Evidence for a jet and outflow from Sgr A*: a continuum and spectral line study
Authors: Yusef-Zadeh F , Royster M , Wardle M , Cotton W , Kunneriath D , Heywood I , Michail J
Published: August 2020

We study the environment of Sgr A* using spectral and continuum observations with the Atacama Large Millimeter/submillimeter Array and Very Large Array. Our analysis of subarcsecond H30 α, H39 α, H52 α , and H56 α line emission towards Sgr A* confirms the recently published broad-peak ∼500 km s−1 spectrum towards Sgr A*. We also detect emission at more extreme radial velocities peaking near −2500 and 4000 km s−1 within 0.2 arcsec. We then present broad-band radio continuum images at multiple frequencies on scales from arcseconds to arcminutes. A number of elongated continuum structures lie parallel to the Galactic plane, extending from ∼0.4 arcsec to ∼10 arcmin. We note a non-thermal elongated structure on an arcminute scale emanating from Sgr A* at low frequencies between 1 and 1.4 GHz where thermal emission from the minispiral is depressed by optical depth effects. The position angle of this elongated structure and the sense of motion of ionized features with respect to Sgr A* suggest a symmetric, collimated jet emerging from Sgr A* with an opening angle of ∼30○ and a position angle of ∼60○ punching through the medium before accelerating a significant fraction of the orbiting ionized gas to high velocities. The jet with an estimated mass flow rate of ∼1.4 × 10−5 M⊙ yr−1 emerges perpendicular to the equatorial plane of the accretion flow near the event horizon of Sgr A* and runs along the Galactic plane. To explain a number of east–west features near Sgr A*, we also consider the possibility of an outflow component with a wider angle launched from the accretion flow at larger radii.
Propagating sample variance uncertainties in redshift calibration: simulations, theory, and application to the COSMOS2015 data
Authors: Sánchez Carles , Raveri Marco , Alarcon Alex , Bernstein Gary M
Published: August 2020

Cosmological analyses of galaxy surveys rely on knowledge of the redshift distribution of their galaxy sample. This is usually derived from a spectroscopic and/or many-band photometric calibrator survey of a small patch of sky. The uncertainties in the redshift distribution of the calibrator sample include a contribution from shot noise, or Poisson sampling errors, but, given the small volume they probe, they are dominated by sample variance introduced by large-scale structures. Redshift uncertainties have been shown to constitute one of the leading contributions to systematic uncertainties in cosmological inferences from weak lensing and galaxy clustering, and hence they must be propagated through the analyses. In this work, we study the effects of sample variance on small-area redshift surveys, from theory to simulations to the COSMOS2015 data set. We present a three-step Dirichlet method of resampling a given survey-based redshift calibration distribution to enable the propagation of both shot noise and sample variance uncertainties. The method can accommodate different levels of prior confidence on different redshift sources. This method can be applied to any calibration sample with known redshifts and phenotypes (i.e. cells in a self-organizing map, or some other way of discretizing photometric space), and provides a simple way of propagating prior redshift uncertainties into cosmological analyses. As a worked example, we apply the full scheme to the COSMOS2015 data set, for which we also present a new, principled SOM algorithm designed to handle noisy photometric data. We make available a catalogue of the resulting resamplings of the COSMOS2015 galaxies.
A combined timing/spectral study of IRAS 13224-3809 using XMM–Newton data
Authors: Caballero-García M D , Papadakis I E , Dovčiak M , Bursa M , Svoboda J , Karas V
Published: August 2020

We present the results from an X-ray variability study of IRAS 13224-3809. This is probably the best source for X-ray reverberation studies since it is X-ray bright, extremely variable, and it has been extensively observed with XMM–Newton. We used all the archival XMM–Newton data from the three EPIC cameras (to increase the signal to noise) and, given the many observations of the source, we were able to compute the time lags spectra in three different flux levels/periods. We fitted the time lags and energy spectra, simultaneously, using a new X-ray reverberation code that computes the time-dependent reflection spectra of the disc as a response to an X-ray flash from a point source located on the axis of the black hole (BH) accretion disc (lamp-post geometry). To the best of our knowledge, this is the first time for active galactic nuclei that both time lags and energy spectra are fitted by a model simultaneously in different flux periods. The model fits in the case when the BH is rapidly rotating are significantly better than the model fits in the case of a Schwarzschild BH. This result strongly favours the hypothesis of a rotating central BH in this source. We also detect significant variations in the height of the X-ray corona. The X-ray height appears to increase from ∼3–5 gravitational radii when the X-ray luminosity is of the order of ∼1.5–3 per cent of the Eddington limit, up to ∼10 gravitational radii, when the luminosity doubles.
Using atmospheric impact data to model meteoroid close encounters
Authors: Shober P M , Jansen-Sturgeon T , Bland P A , Devillepoix H A R , Sansom E K , Towner M C , Cupák M , Howie R M , Hartig B A D
Published: August 2020

Based on telescopic observations of Jupiter-family comets (JFCs), there is predicted to be a paucity of objects at sub-kilometre sizes. However, several bright fireballs and some meteorites have been tenuously linked to the JFC population, showing metre-scale objects do exist in this region. In 2017, the Desert Fireball Network (DFN) observed a grazing fireball that redirected a meteoroid from an Apollo-type orbit to a JFC-like orbit. Using orbital data collected by the DFN, in this study, we have generated an artificial data set of close terrestrial encounters that come within 1.5 lunar distances (LD) of the Earth in the size-range of 0.01–100 kg. This range of objects is typically too small for telescopic surveys to detect, so using atmospheric impact flux data from fireball observations is currently one of the only ways to characterize these close encounters. Based on this model, we predict that within the considered size-range 2.5 × 108 objects ($0.1{{\ \rm per\ cent}}$ of the total flux) from asteroidal orbits (TJ > 3) are annually sent on to JFC-like orbits (2 < TJ < 3), with a steady-state population of about 8 × 1013 objects. Close encounters with the Earth provide another way to transfer material to the JFC region. Additionally, using our model, we found that approximately 1.96 × 107 objects are sent on to Aten-type orbits and ∼104 objects are ejected from the Solar system annually via a close encounter with the Earth.
Box/peanut-shaped bulges in action space
Authors: Debattista Victor P , Liddicott David J , Khachaturyants Tigran , Beraldo e Silva Leandro
Published: August 2020

We introduce the study of box/peanut (B/P) bulges in the action space of the initial axisymmetric system. We explore where populations with different actions end up once a bar forms and a B/P bulge develops. We find that the density bimodality due to the B/P bulge (the X-shape) is better traced by populations with low radial, ${\it J}_{R,0}$, or vertical, ${\it J}_{z,0}$, actions, or high azimuthal action, ${\it J}_{\phi ,0}$. Generally, populations separated by ${\it J}_{R,0}$ have a greater variation in bar strength and vertical heating than those separated by ${\it J}_{z,0}$. While the bar substantially weakens the initial vertical gradient of ${\it J}_{z,0}$, it also drives a strikingly monotonic vertical profile of ${\it J}_{R,0}$. We then use these results to guide us in assigning metallicity to star particles in a pure N-body model. Because stellar metallicity in unbarred galaxies depends on age as well as radial and vertical positions, the initial actions are particularly well suited for assigning metallicities. We argue that assigning metallicities based on single actions, or on positions, results in metallicity distributions inconsistent with those observed in real galaxies. We therefore use all three actions to assign metallicity to an N-body model by comparing with the actions of a star-forming, unbarred simulation. The resulting metallicity distribution is pinched on the vertical axis, has a realistic vertical gradient, and has a stronger X-shape in metal-rich populations, as found in real galaxies.
SPIRou: NIR velocimetry and spectropolarimetry at the CFHT
Authors: Donati J-F , Kouach D , Moutou C , Doyon R , Delfosse X , Artigau E , Baratchart S , Lacombe M , Barrick G , Hébrard G , Bouchy F , Saddlemyer L , Parès L , Rabou P , Micheau Y , Dolon F , Reshetov V , Challita Z , Carmona A , Striebig N , Thibault S , Martioli E , Cook N , Fouqué P , Vermeulen T , Wang S Y , Arnold L , Pepe F , Boisse I , Figueira P , Bouvier J , Ray T P , Feugeade C , Morin J , Alencar S , Hobson M , Castilho B , Udry S , Santos N C , Hernandez O , Benedict T , Vallée P , Gallou G , Dupieux M , Larrieu M , Perruchot S , Sottile R , Moreau F , Usher C , Baril M , Wildi F , Chazelas B , Malo L , Bonfils X , Loop D , Kerley D , Wevers I , Dunn J , Pazder J , Macdonald S , Dubois B , Carrié E , Valentin H , Henault F , Yan C H , Steinmetz T
Published: August 2020

This paper presents an overview of SPIRou, the new-generation near-infrared spectropolarimeter/precision velocimeter recently installed on the 3.6-m Canada–France–Hawaii Telescope (CFHT). Starting from the two main science goals, i.e., the quest for planetary systems around nearby M dwarfs and the study of magnetized star/planet formation, we outline the instrument concept that was designed to efficiently address these forefront topics, and detail the in-lab and on-sky instrument performances measured throughout the intensive testing phase that SPIRou was submitted to before passing the final acceptance review in early 2019 and initiating science observations. With a central position among the newly started programmes, the SPIRou Legacy Survey (SLS) Large Programme was allocated 300 CFHT nights until at least mid 2022. We also briefly describe a few of the first results obtained in the various science topics that SPIRou started investigating, focusing in particular on planetary systems of nearby M dwarfs, transiting exoplanets and their atmospheres, magnetic fields of young stars, but also on alternate science goals like the atmospheres of M dwarfs and the Earth’s atmosphere. We finally conclude on the key role that SPIRou and the CFHT can play in coordination with forthcoming major facilities like the JWST, the ELTs, PLATO, and ARIEL over the decade.
Testing jet geometries and disc–jet coupling in the neutron star LMXB 4U 0614 + 091 with the internal shocks model
Authors: Marino A , Malzac J , Del Santo M , Migliari S , Belmont R , Di Salvo T , Russell D M , Lopez Miralles J , Perucho M , D’Aì A , Iaria R , Burderi L
Published: August 2020

Multiwavelength spectral energy distributions of low-mass X-ray binaries (LMXBs) in the hard state are determined by the emission from a jet, for frequencies up to mid-infrared, and emission from the accretion flow in the optical to X-ray range. In the last years, the flat radio-to-mid-IR spectra of black hole (BH) X-ray binaries was described using the internal shocks model, which assumes that the fluctuations in the velocity of the ejecta along the jet are driven by the fluctuations in the accretion flow, described by the X-ray power density spectrum (PDS). In this work, we attempt to apply this model for the first time to a neutron star (NS) LMXB, i.e. 4U 0614 + 091. We used the multiwavelength data set obtained in 2006, comprising data from radio to X-ray, and applied a model that includes an irradiated disc model for the accretion flow and an updated version of the internal shocks code for the ejection. The new version of the code allows to change the geometry of the jet for the case of non-conical jets. Only two alternative scenarios provide a satisfactory description of the data: using the X-ray PDS but in a non-conical geometry for the jet, or either using a conical geometry but with a ‘flicker-noise’ PDS. Both scenarios would imply some differences with the results obtained with similar models on BH X-ray binaries, shedding light on the possibility that jets in NS and BH binaries might somehow have a different geometry or a different coupling with the accretion flow.
ETHOS – an effective parametrization and classification for structure formation: the non-linear regime at z ≳ 5
Authors: Bohr Sebastian , Zavala Jesús , Cyr-Racine Francis-Yan , Vogelsberger Mark , Bringmann Torsten , Pfrommer Christoph
Published: August 2020

We propose two effective parameters that fully characterize galactic-scale structure formation at high redshifts (z ≳ 5) for a variety of dark matter (DM) models that have a primordial cutoff in the matter power spectrum. Our description is within the recently proposed ETHOS framework and includes standard thermal warm DM (WDM) and models with dark acoustic oscillations (DAOs). To define and explore this parameter space, we use high-redshift zoom-in simulations that cover a wide range of non-linear scales from those where DM should behave as CDM (k ∼ 10 h Mpc−1), down to those characterized by the onset of galaxy formation (k ∼ 500 h Mpc−1). We show that the two physically motivated parameters hpeak and kpeak, the amplitude and scale of the first DAO peak, respectively, are sufficient to parametrize the linear matter power spectrum and classify the DM models as belonging to effective non-linear structure formation regions. These are defined by their relative departure from cold DM (kpeak → ∞) and WDM (hpeak = 0) according to the non-linear matter power spectrum and halo mass function. We identify a region where the DAOs still leave a distinct signature from WDM down to z = 5, while a large part of the DAO parameter space is shown to be degenerate with WDM. Our framework can then be used to seamlessly connect a broad class of particle DM models to their structure formation properties at high redshift without the need of additional N-body simulations.
ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
Authors: Britton Sébastien , Chanut Pauline , Delteil Christine , Barboule Nadia , Frit Philippe , Calsou Patrick
Published: August 2020

Two DNA repair pathways operate at DNA double strand breaks (DSBs): non-homologous end-joining (NHEJ), that requires two adjacent DNA ends for ligation, and homologous recombination (HR), that resects one DNA strand for invasion of a homologous duplex. Faithful repair of replicative single-ended DSBs (seDSBs) is mediated by HR, due to the lack of a second DNA end for end-joining. ATM stimulates resection at such breaks through multiple mechanisms including CtIP phosphorylation, which also promotes removal of the DNA-ends sensor and NHEJ protein Ku. Here, using a new method for imaging the recruitment of the Ku partner DNA-PKcs at DSBs, we uncover an unanticipated role of ATM in removing DNA-PKcs from seDSBs in human cells. Phosphorylation of DNA-PKcs on the ABCDE cluster is necessary not only for DNA-PKcs clearance but also for the subsequent MRE11/CtIP-dependent release of Ku from these breaks. We propose that at seDSBs, ATM activity is necessary for the release of both Ku and DNA-PKcs components of the NHEJ apparatus, and thereby prevents subsequent aberrant interactions between seDSBs accompanied by DNA-PKcs autophosphorylation and detrimental commitment to Lig4-dependent end-joining.
Long-term efficacy of surgical resection with or without adjuvant therapy for treatment of secondary glioblastoma in adults
Authors: Huang Ruoyu , Li Guanzhang , Li Yiming , Wang Yinyan , Yang Pei , Zhang Chuanbao , Wang Zheng , Zhou Dabiao , Zhang Wei , Zhang Zhong , Jiang Tao
Published: August 2020

Background

There are limited studies on treatment strategies and associated clinical outcomes in patients with secondary glioblastoma (sGBM). We sought to investigate the prognostic factors and treatment decisions in a retrospective cohort of patients with sGBM.

Methods

One hundred and seventy-one patients with sGBM who met the screening criteria were included in this study. Kaplan–Meier survival analysis and Cox survival analysis were used to detect prognostic factors. R (v3.5.0) and SPSS software (v25.0, IBM) were used to perform statistical analyses.

Results

The median overall survival was 303 days (range 23–2237 days) and the median progression-free survival was 229 days (range 33–1964 days) in patients with sGBM. When assessing the relationship between adjuvant treatment outcome and extent of resection (EOR), the results showed that patients underwent gross total resection can benefit from postoperative radiotherapy and chemotherapy, but not in patients underwent subtotal resection. In addition, we also found that aggressive adjuvant therapy can significantly improve clinical outcomes of IDH1-mutated patients but no significant prognostic value for IDH1-wildtyped patients. The univariate Cox regression analyses demonstrated that EOR, adjuvant therapy, and postoperative Karnofsky Performance Scores were prognostic factors for patients with sGBM, and multivariate COX analysis confirmed that adjuvant therapy and EOR were independent prognostic factors.

Conclusions

For patients with sGBM, aggressive postoperative adjuvant therapy after gross total resection was recommended. However, we did not detect a benefit in IDH1-wildtype patients in our cohort.
Exploring ancestral phenotypes and evolutionary development of the mammalian middle ear based on Early Cretaceous Jehol mammals
Authors: Mao Fangyuan , Liu Cunyu , Chase Morgan Hill , Smith Andrew K , Meng Jin
Published: August 2020

We report a new Cretaceous multituberculate mammal with 3D auditory bones preserved. Along with other fossil and extant mammals, the unequivocal auditory bones display features potentially representing ancestral phenotypes of the mammalian middle ear. These phenotypes show that the ectotympanic and the malleus-incus complex changed notably during their retreating from the dentary at various evolutionary stages and suggest convergent evolution of some features to extant mammals. In contrast, the incudomalleolar joint was conservative in having a braced hinge configuration, which narrows the morphological gap between the quadroarticular jaw joint of non-mammalian cynodonts and the incudomalleolar articulations of extant mammals. The saddle-shaped and abutting malleus-incus complexes in therians and monotremes, respectively, could have evolved from the braced hinge joint independently. The evolutionary changes recorded in the Mesozoic mammals are largely consistent with the middle ear morphogenesis during the ontogeny of extant mammals, supporting the relation between evolution and development.
Does employment protection affect unemployment? A meta-analysis
Authors: Heimberger Philipp
Published: August 2020

Despite extensive research efforts, the magnitude of the effect of employment protection legislation (EPL) on unemployment remains unclear. This article applies meta-analysis and meta-regression methods to a unique data set consisting of 881 observations on the effect of EPL on unemployment from 75 studies. Once we control for publication selection bias, we cannot reject the hypothesis that the average effect of EPL on unemployment is zero. The meta-regression analysis, however, reveals that the choice of the EPL variable matters: estimates that build on survey-based EPL variables report a significantly stronger unemployment-increasing impact of EPL than estimates developed using EPL indices based on the OECD’s methodology, where the latter relies on coding information from legal provisions. Furthermore, using multi-year averages of the underlying data tends to dampen the reported unemployment effects of EPL, and product market regulation serves as a significant moderator variable.
Colchicine treatment increases the risk for fetal chromosomal aberrations—an observational study and systematic literature review
Authors: Singer Amihood , Grinshpun-Cohen Julia , Sagi-Dain Lena
Published: August 2020

Objectives

To examine the risk for chromosomal aberrations in fetuses of colchicine-treated patients in a large cohort, and to perform a systematic literature review on the subject.

Methods

For the observational study, a retrospective search was performed through the Ministry of Health computerized database, for all invasive tests performed due to parental colchicine treatment over the years 2003–19. The rate of aberrant karyotypes in pregnancies exposed to colchicine was compared with a local cohort of 2752 normal pregnancies, yielding six (0.2%) karyotype-detectable findings. In addition, a systematic literature search was conducted for studies examining the rate of chromosomal aberrations in pregnancies exposed to colchicine.

Results

The study group consisted of 755 pregnancies karyotyped due to colchicine exposure. A marked decrease due to this indication was noted over the years (i.e. 67 cases in 2003 vs 8 in 2019). Five (0.66%) chromosomal aberrations were noted: 47,XXY; 45,X0; 47,XYY; and two fetuses with trisomy 21. This rate was significantly increased compared with the control population [relative risk 2.2 (95% CI: 1.1, 4.2)]. Literature search yielded four studies encompassing 740 pregnancies. The rate of chromosomal aberrations ranged from ‘none’ (in three studies) up to 1.5%. Quality assessment of the evidence was defined as ‘low’.

Conclusion

The results of our observational study support the concern that colchicine treatment is associated with increased risk for fetal chromosomal aberrations; however, the absolute risk is relatively low (one in 151 pregnancies). This information should be taken into account when considering invasive testing in such pregnancies.