bluuebunny/crossref_metadata_2025 huggingface dataset:
SOMATOMETRIC MEASUREMENTS OF MALES DURING PRENATAL EXPOSURE TO AN OESTROGENIC DRUG
Authors: Sulaimanova Rimma , Kvochko Andrey
Published: November 2024

Excessive hormones and chemical compounds used
during pregnancy can have a delayed negative effect on the reproductive
organs of the offspring. Manifestations of negative
prenatal effects of hormones are the following indicators: body
weight, body length, tail length, length and width of the head,
and a number of other somatometric indicators. The aim of the
study was to investigate the somatometric measurements of
the male offspring when their mothers were exposed to the estrogenic
drug fulvestrant at a dose of 200 mkg/kg during pregnancy.
Experimental white non-pedigreed laboratory female
mice received a single intramuscular injection of the estrogen
drug fulvestrant on day 11 of gestation E 11.5 of gestation.
The intact group of females remained unaffected (physiological
pregnancy). Somatometric analysis of body weight, body
length, nose – to – ear length, ear – to – ear length, tail length,
hind right foot length and anogenital distance (AGR) was performed
in the obtained offspring at 1 month of postnatal development;
the obtained data were compared in pairs with similar
parameters of the intact and experimental groups offspring.
Thus, the male offspring obtained at the age of 1 month of
postnatal development as a result of exposure of their pregnant
mothers to the estrogenic drug – fulvestrant, changes in
somatometric indices were observed. Thus, the male offspring
obtained at the age of thirty days of postnatal development as
a result of their pregnant mothers’ injection of the estrogenic
drug fulvestrant, changes in somatometric indices were observed.
Studies of the biological model of the effects of estrogentype
drugs during pregnancy can help to predict pathological
changes in the reproductive system at early diagnosis and
develop a set of preventive measures in the period of organ
initiation and development.
MONITORING OF ANTIBIOTIC RESISTANCE OF ESCHERICHIA COLI WOUND DISCHARGE
Authors: Orlova Nadezhda , Ponomareva Maria , Permanova Kristina
Published: November 2024

The aim of the work was to evaluate the dynamics
of antibiotic resistance of Escherichia coli in the wound
contents of dogs and cats. The work was performed on the
basis of the veterinary clinic of the Federal State Budgetary
Educational Institution of Higher Education RGAU-MSHA
named after K. A. Timiryazev. In animals with clinical signs
of open wounds complicated by wound infection, the exact
localization of the wound was recorded, pathological material
was taken for the purpose of microbiological analysis, and if
E. coli was detected in the pathological material, sensitivity to
antibacterial drugs was determined using the disk diffusion
method. For the first time in the conditions of Moscow, the
distribution of E. coli as a causative agent of wound infection
was studied and the resistance of this pathogen to various
antibiotics was studied. It was found that the frequency of
occurrence of E. coli in the wound discharge in dogs was
higher than in cats, in 75 % of cases it was found in wounds
localized on the distal extremities of large dogs, it was
isolated in 15 % (9 cases). E. coli is not sensitive to penicillin
(ampicillin, amoxicillin) and cephalosporin (cephalexin) drugs,
but is sensitive to tetracyclines (doxycycline), chloramphenicol
(chloramphenicol), aminoglycosides (gentamicin) and is most
sensitive to fluoroquinolones (enrofloxacin and ciprofloxacin).
E. coli is sensitive to doxycycline, chloramphenicol, gentamicin,
ciprofloxacin, and to a greater extent to enrofloxacin. There is a
trend towards a continued decrease in the sensitivity of E. coli
to antibacterial drugs, but there is a preservation of sensitivity
to enrofloxacin, as well as a delayed decrease in sensitivity
to ciprofloxacin. There is an obvious need to develop empiric
antibiotic therapy schemes based on monitoring data on
antibiotic susceptibility of microorganisms.
MONITORING THE NUMBER OF PHYTOPHAGES IN CROPS OF DIFFERENT VARIETIES OF WINTER WHEAT
Authors: Glazunova Natalia , Khomutova Anna , Bezgina Juliya
Published: November 2024

The article presents data on the study of the influence
of varieties on the dynamics of the number of phytophages
in the spring-summer growing season of winter wheat in
the conditions of the zone of unstable humidification of the
Stavropol Territory. The research was carried out in 2020–2022
on the territory of the educational and experimental farm of the
Stavropol State Agrarian University in the crops of Alekseich,
Vassa and Tanya varieties. The objects of observations were
the red-breasted pyavica (Oulema melanopus L.), the harmful
bug turtle (Eurygaster integriceps Put.), large grass aphid
(Schizaphis graminum Rond.), common grass aphid (Sitobion
avenae F.), w heat t hrips ( Haplothrips tritici Kurd.), common
bread sawflies (Cephus pygmaeus L .) a nd b lack ( Trachelus
tabidus F.). The Vassa variety contributes to a decrease in
the population of the harmful turtle bug by 45.7 % and cereal
aphids by 46.4 % in the agrobiocenosis of winter wheat, this is
due to two reasons: first, it has a strong wax coating on the ear,
which makes it difficult for the imago and phytophagus larvae
to feed; second, it is medium-early, so wax ripeness occurs
earlier than that of the Alekseich variety, which prevents the
normal development of the larvae of the younger pest. The
Tanya variety is able to reduce the number of the harmful turtle
bug by 12.8 %, due to the fact that it is medium-early and wax
ripeness occurs 6–8 days earlier than the Alekseich variety,
some of the younger larvae do not have time to eat. Also, this
variety has a certain resistance to the red-breasted piavica,
since the population of the phytophagus in all the years of
observation was 25.0–35.3 % lower than in the crops of the
Vassa and Alekseich varieties. Varieties Alekseich, Tanya and
Vassa in the zone of unstable humidification of the Stavropol
Territory do not have a significant effect on the number of
populations of wheat thrips and bread sawflies.
PERAN BIMBINGAN PADA DIRI ORANG TUA DALAM PENERIMAAN ANAK BERKEBUTUHAN KHUSUS DI SLB
Authors: Rusda Lulu Utya , Nurdin Nurdin , Fauziah Siti , Rahmawati Rahmawati
Published: November 2024

Penelitian ini bertujuan untuk mengetahui peran bimbingan pada diri orang tua dalam penerimaan pada anak berkebutuhan khusus, dan apa yang mempengaruhi penerimaan diri orang tua yang memiliki anak berkebutuhan khusus, serta tahap orang tua dalam menerima anak sepenuh hati. Metode yang digunakan pada penelitian ini adalah metode deskriptif dengan jenis penelitian kualitatif. Pengumpulan data dilakukan dengan wawancara, observasi, dan studi dokumentasi yang diperoleh langsung dari sumber yang terkait. Teknik analisis data dilakukan dengan tahapan redaksi data, displai data dan verifikasi data pengambilan kesimpulan. Hasil penelitian menunjukan bahwa: proses tahapan awal yang dilalui orang tua yang memiliki anak berkebutuhan khusus ialah penolakan, kemarahan, tawar-menawar, depresi, dan penerimaan diri walaupun ada salah satu orang tua menerima anak mereka tanpa adanya penolakan. Proses penerimaan orang tua anak berkebutuhan khusus, peranan dan tanggung jawab yang dilakukan orang tua yang memiliki anak kebutuhan khusus ialah sama seperti anak lainnya memberi dukungan, fasilitas, memberikan makanan yang bergizi, mengasuh, serta menjaganya. Peran pembimbing dalam bimbingan orang tua untuk lebih mengenal anak mereka dengan memberikan informasi terkait anak selama di sekolah dan memberikan materi-materi yang bisa di pelajari orang tua dalam merawat anak mereka. Serta tahap dimana orang tua mulai menerima anak mereka dengan baik.
PERANAN TA’LIM PENYULUH AGAMA ISLAM DALAM MENINGKATKAN RELIGIUSITAS REMAJA MASJID
Authors: Fauzia Wa Ode Nilal , Akib Nasri , Mayasari Ros , Syamsu Khairunnisa
Published: November 2024

Penelitian kualitatif ini bertujuan untuk mendeskripsikan peranan ta’lim Penyuluh Agama Islam dalam meningkatkan religiusitas Remaja Masjid Al-Muhajirin. Data dikumpulkan melalui observasi, wawancara dan dokumentasi pelaksanaan kegiatan ta’lim yang dilakukan oleh Penyuluh Agama Islam terhadap Remaja Masjid. Hasil penelitian menunjukan bahwa peranan ta’lim yang dilakukan Penyuluh Agama Islam terhadap Remaja Masjid diantaranya adalah menjaga pendidikan keagamaan tetap berkesinambungan, melatih remaja masjid sebagai pemimpin, memperkuat silaturahmi, menghadirkan sikap cinta masjid dan perilaku yang menjadi religius. Faktor pendukung pelaksanaan ta’lim diantaranya adalah antusiasme dari Remaja Masjid untuk belajar agama, dukungan dari orang tua, ajakan dari teman-teman Remaja Masjid, dukungan dari Pembina Remaja Masjid, lingkungan Masjid Al-Muhajirin yang strategis, masyarakat yang memberikan akses dan fasilitas kepada siapa saja yang melakukan ta’lim atau dakwah di Masjid Al-Muhajirin, dan adanya prasarana penunjang ta’lim. Faktor penghambat pelaksanaan ta’lim yaitu kondisi remaja yang sulit diprediksi sehingga berpengaruh pada keaktifan dalam mengikuti ta’lim, waktu pelaksanaan ta’lim yang biasa bersamaan dengan kegiatan Penyuluh Agama Islam yang lain, waktu kegiatan ta’lim yang bersamaan dengan kesibukan Remaja Masjid dan eksternal dari Organisasi Masyarakat lain yang merasa belum bisa melakukan ta’lim kepada Remaja Masjid Al-Muhajirin.
A utilização da ozonioterapia no tratamento de hérnia de disco em cão
Authors: Rodrigues Vanessa Ribeiro , Siqueira Roberto , Alves Neto Aldo Francisco
Published: November 2024

Herniated disc is an affection of the intervertebral disc that often affects dogs of all breeds, ages and sex, and may have higher incidence in the breeds Dachshund, Pug, Cocker Spaniel and Pekinese. There are predisposing causes for the development of these discopathies, such as obesity, anatomical peculiarities of the spine of some breeds, falls, or trauma. The affected patients usually present pain, resistance to locomotion, proprioceptive ataxia, urinary and fecal incontinence or urinary retention, loss of sensation in the extremities, and may evolve to paresis or paralysis. Diagnosis is made by imaging exams, most commonly magnetic resonance and/or tomography, which indicate disc protrusions and extrusions causing spinal cord compression and dehydration/degeneration of the intervertebral disc. Treatment depends on the clinical condition of the animal, and may involve drug treatment, integrative medicine such as ozone therapy, physiotherapy, acupuncture or, in more severe cases such as disc extrusion, even surgery. In this report, the case of a 07-year-old pug dog that underwent ozone therapy sessions as a treatment for disc herniation will be discussed. The animal presented great recovery after 10 sessions of ozone therapy through paravertebral, trigger point and rectal insufflation techniques. Because it is a very common diagnosis in the clinical routine, the investigation of clinical signs, complementary exams and knowledge surrounding anatomy and ozone therapy techniques is of the utmost importance in obtaining the correct diagnosis and success in the integrative treatment.
Gestação ectópica com mumificação fetal em cadela
Authors: Silveira Dyego Deleon Mendes da , Gomes Caroline Ribeiro , Mota Nayane dos Reis , Silva Iara Souza , Barbosa Vivian de Brito , Aguiar Thais Pereira , Medina Dandara Campos Dirino , Paula Mhaique Henrique de , Hamade Vanessa do Carmo Eleto , Sá Roger Richelle Bordone de
Published: November 2024

Ectopic pregnancy is a condition where the fetus develops in atypical locations, whether intrauterine or extrauterine. Among the forms of ectopic pregnancy, secondary abdominal pregnancy is the most described in the literature. It develops as a consequence of trauma that causes uterine rupture. The aim of this study is to report a case in which a patient, with a history of trauma due to a car accident, presented a mummified fetus in the abdominal cavity. The patient was admitted with a complaint of dystocia and, after a C-section, an ovariohysterectomy was performed. During inspection of the abdominal cavity, a mummified fetus, enveloped by the omentum, was identified and carefully removed, separating the attached structures. During the ovariohysterectomy procedure, no macroscopic signs of scarring were observed in the uterus. The patient and her puppies did not present any complications during or after the procedure, and the adopted approach was effective, resulting in a normal birth for the puppies and a complication-free postoperative period for the mother.
Crown gall of grapevine and prospects for its biological control
Authors: Konup Liudmila , Pikovskyi Myroslav , Riabyi Mykola , Konup Anastasiia , Kyryk Mykola
Published: November 2024

The relevance of this study is conditioned by the spread of bacterial diseases of grapes in the south of Ukraine and the necessity of improving methods of pathogen identification and protection. The purpose of this study was to establish the area of bacterial grape cancer in Odesa region and to develop preventive measures based on the biological method. The study involved the inspection of industrial plantations for symptoms of the disease and its spread in the field. The molecular biological method of real-time polymerase chain reaction (PCR) was employed to identify the crown gall pathogen. The study was conducted following a certified methodology. PCR laboratory equipment was used to identify phytopathogens. As a result of the phytosanitary inspection of grape plantations of various farms in Odesa region, the study found grape bushes with characteristic symptoms of crown gall, with tumorous tissue growths in various parts of the plants: on the branches, stem, and grafting sites. Overall, grape crown gall is characterised by a wide distribution in the study area. According to the findings of the phytosanitary survey, the spread of bacterial grape cancer on different varieties ranged between 0.3-35%. The causative agent of the disease, A. tumefaciens, was identified in real time by PCR. The disease manifested itself in the form of characteristic symptoms and developed in a latent form. The developed multiplex PCR allowed for the simultaneous analysis of multiple strains of pathogenic agrobacterial isolates. Two isolates of agrobacteria were identified among the majority of isolates that were subsequently tested for tumour suppression: ILVM1 and ILVM2, which had elevated levels of antagonistic properties against the crown gall pathogen. The pathogenicity of the isolated agrobacteria on test plants of tomato and sunflower confirmed the findings of these properties obtained in vitro. The isolates of ILVM1 and ILVM2 agrobacteria considerably inhibited the growth of tumours on the stems of test plants compared to the pathogenic strain, and therefore they can be used in the future against the crown gall pathogen and to protect grape plants from secondary infection by the pathogen from the soil. The findings can be used to improve methods of biological plant protection against bacterial infections
The effectiveness of intercropping in the Forest-Steppe zone of Ukraine
Authors: Mokrienko Volodymyr , Kalenska Svitlana , Andriec Dmitro
Published: November 2024

Intercropping of agricultural crops offers a valuable technological solution for resource conservation and improved crop yield, essential to global food security. This study aimed to assess the effectiveness of intercropping maize and soybeans. Scientific methods were employed for conducting field and laboratory research, with experimental findings analysed statistically and interpreted. The study established that intercropping maize variety RAGT Zanetikks with soybean varieties Sirelia and Sakuza provides several advantages over monoculture cropping, especially in terms of yield formation. Maize demonstrated efficient utilisation of additional soil nitrogen fixed by soybeans in mixed plantings, resulting in significant maize yield gains across all fertiliser levels and even without fertilisation. The increase in maize yield in intercropped systems, compared with monoculture, ranged from 10.3% to 19.3%, depending on the fertiliser rate. The highest maize yield was achieved with N90P60K60 fertilisation: 10.26 t/ha in monoculture and 12.19-12.24 t/ha in intercropped systems. Although soybean yield declined in intercropped plantings, the combined yield of both crops in intercropping systems showed a substantial increase, reaching 14.51-14.70 t/ha under N90P60K60 conditions. The yield was strongly correlated with the leaf area index (r=0.93‑0.99). Soil nitrate nitrogen content was higher under soybean but decreased under intercropping systems. Soil biological activity increased with N60P45K45 fertilisation in maize and soybean monocultures (39.4 and 47.2 mg CO2/kg soil/day, respectively) and reached 52.6-55.1 mg CO2/kg soil/day in intercropped plantings. These findings have significant practical implications for production, promoting resource conservation and increasing gross grain production
Evaluating Student Self-Management, Interpersonal Skills, and Academic Behaviors
Authors:   Abai Kazakh National Pedagogical University, Kassymova G.K. ,   Institute of Metallurgy and Ore Beneficiation JSC, Satbayev University, Nursa'ban M. ,   Yogyakarta State University, Suleimen S.B. ,   Abai Kazakh National Pedagogical University, Rifqiyah F. ,   Yogyakarta State University, Sultan J. ,   Yogyakarta State University
Published: November 2024

This study examines the relationships between student self-management, interpersonal skills, and academic behavior through detailed statistical analysis of survey data. The survey used a Likert scale ranging from "strongly disagree" to "strongly agree" to assess respondents' perceptions of these three areas. To analyze the data, we used the JASP Frequencies: Binomial Test function, which was specifically designed to calculate confidence intervals for the proportions of responses at each level of agreement. The analysis involved calculating 95% confidence intervals for the proportion of respondents who selected each Likert scale category for each survey item. These intervals provide a range within which the true proportion of responses may fall, offering insights into general trends and the distribution of respondents' views. In addition, we used the Vovk-Sellke maximum p-ratio to further interpret the significance of the results to help understand the strength of the evidence against the null hypothesis. This exploratory analysis not only demonstrates the variability and reliability of respondents' responses, but also provides a deeper understanding of how students' self-management, interpersonal skills, and academic behaviors are perceived at different levels of agreement. Using these statistical methods, research aims to uncover patterns and relationships in the data, thereby contributing to a deeper understanding of the factors that influence student achievement.
The use of diatomites in industrial production technologies
Authors:   Satbayev University, Institute of Metallurgy and Ore Beneficiation JSC, Temirova S. , Fischer D. ,   Satbayev University, Institute of Metallurgy and Ore Beneficiation JSC, Kuldeyev Ye. ,   Satbayev University, Institute of Metallurgy and Ore Beneficiation JSC
Published: November 2024

General information on the distribution and reserves of diatomites in the world and Kazakhstan is presented, and their physical and chemical properties and applications are described. Diatomites have several valuable properties: high porosity, refractoriness, acid resistance, low thermal and acoustic conductivity, low bulk density and due to the large specific surface exhibit significant absorption capacity. It allows to use of them as fillers and heat-insulating materials in building technologies, filtering materials in the food industry, adsorbents in medicine, soil structuring agents and carriers of insecticides in the agrarian industry. The technologies for obtaining several industrial products with the use of Kazakhstani diatomites are described: as dry building mixtures, silicate bricks, foam glass, hydraulic binders, and iron oxide pigments.
Wastewater treatment from hydrogen sulphide using iron-containing coagulant
Authors:   Satbayev University, Institute of Metallurgy and Ore Beneficiation JSC, Temirova S. , Fischer D. ,   Satbayev University, Institute of Metallurgy and Ore Beneficiation JSC, Kuldeyev Ye. ,   Satbayev University, Institute of Metallurgy and Ore Beneficiation JSC
Published: November 2024

The increase of sulphate content in natural water sources due to anthropogenic causes leads to a corresponding increase of sulphate and sulphide concentrations in wastewater. Biochemical reactions occurring in sewage systems of sulphate reduction to sulphides and their subsequent oxidation to sulphuric acid cause microbially induced acid corrosion of concrete pipes. In addition, biochemical processes occurring in wastewater are accompanied by the release of toxic gases, including hydrogen sulphide, which adversely affect the human body. The methods based on the binding of hydrogen sulphide into insoluble metal sulphide are recognised as promising for the treatment of sulphide-containing waters. For the realisation of the process, it is offered to use iron compounds as the least toxic and relatively cheap reagents. The complex coagulant based on ferric diatomite, sodium ferrite and iron compounds for the treatment of wastewater from hydrogen sulphide is developed. Test tests of iron-containing coagulant have been carried out: at a flow rate of sewage 2,73 m3/hour, optimal dose of reagent 90 mg/l the concentration of hydrogen sulphide in treated water is 1,07 mg/l, that is close to maximum permissible concentration (MPC) values for sewage - 1 mg/l.
Comparative Analysis of Sorbents on Chromate Ion (VI) Sorption and Desorption: Influence of Composition and pH from Ilmenite Processing Solutions
Authors:   Satbayev University, Institute of Metallurgy and Ore Beneficiation JSC, Baishibekov A. , Purwaningsih D. ,   Universitas Negeri Yogyakarta, Toilanbay G. ,   Satbayev University, Institute of Metallurgy and Ore Beneficiation JSC, Al Azzam Khaldun M. ,   University of Jordan
Published: November 2024

In this work, the processes of sorption and desorption of chromate ions from the solution obtained as a result of the processing of high-chromium ilmenite concentrate were studied using sorbents: Amberlite IR120 (Na), Amberlite IRA-35, PuroliteA-100, LewatitMono Plus M-500. The influence of pH factor and sorption system composition on the sorption process of chromate ions (VI) was investigated. Different polymers were tested to evaluate their combined effect on the recovery of chromate ions. A correlation was found between the increase in the efficiency of the sorption process of chromate ions (98%) and a decrease in pH from pH 13.5 to pH 2.5. In addition, the sorption process was improved at higher sorbent concentrations and the desorption efficiency increased at higher molar concentrations of sodium hydroxide (NaOH). The study's results will serve for the optimization of sorption processes for the extraction of chromate ions (VI) with the participation of various polymeric sorbents in the industry.
Innovative Leadership: Impact and Challenges in Secondary and Higher Secondary Institutes of Pakistan
Authors: Khan Muhammad Pervez , Ali Nazakat
Published: November 2024

This study investigates the impact of innovative leadership and identifies the challenges faced by such leadership in educational institutes in Pakistan. The study used a qualitative research technique of research design for investigation and data was collected through open-ended questionnaire-cum interview. Innovative dimensions like Creativity/brainstorming, technology innovation, and skilled development innovation in teaching pedagogies have been focused on in this study. The results of this study suggest that there is a significant impact of innovative leadership dimensions on the implementation considering organizational improvement, efficiency, and performance. Challenges faced by innovative leadership were also discussed/identified through results that need to be addressed accordingly for the consistent growth in secondary and higher secondary educational institutes of Pakistan.
Historical Analysis of Environmental Degradation in Pakistan: A Narrative Review
Authors: Rafiq-uz-Zaman Muhammad , Khalid Nimra , Shafi Shumaila
Published: November 2024

The degradation of the environment in Pakistan has become worse through historical, socio-economic, and geopolitical interactions. This narrative review considers burning issues like deforestation, water shortage, and soil and water pollution, which can be linked to colonialism, industrial change, and urbanization. The review is an analysis that takes into consideration the political ecology approach, which demonstrates how political power has led to resource capture and environmental unfairness. This approach enhances the aspect of sustainability, stating measures be drawn from other nations to avoid further harm to ecology. While policy compliance is weak, promoting industrial development has brought negative impacts, according to the review of policy solutions such as afforestation programs, integrated management, and sustainable policies. The recommendations include reinforcing and promoting environmental legislation, improving intersectoral cooperation, and finding sustainable development that would help strengthen Pakistan's ecological base.
An Analytical Study of Semiotic Perspectives in Simpsons’ Seasons: Fiction cum Reality
Authors: Wafa Nida , Abdullah Muhammad , Shoukat Tehreem
Published: November 2024

Language plays an indispensable role in human communication. It has many forms, and each form has specific goals. This research explores the intricate interplay of semiotic elements within the iconic animated television series, Simpsons, across multiple seasons. Language in its multiple manifestations can also play a significant role in determining the relation between fiction and reality. The researchers have opted for a qualitative approach to analyzing the data in this regard. The most relevant Seasons were targeted and specific scenes of the selected episodes from these Seasons were analyzed critically. The study focused on ten predictions that relate to real-life events. In the semiotic analysis, the researchers targeted two levels of meaning: denotative and connotative. The first referred to literal meanings whereas the second more profound and contextualized ones. The findings illustrate that semiotics, in its various dimensions, play a significant role in the predictions of subsequent realities in the Simpsons.
EFFECT OF SHELLAC ON STRENGTH AND WATER RESISTANCE PROPERTIES OF Na2SiO3 AS WOOD ADHESIVE
Authors: Choudhary Manju , Jat Meena , Pal Bhupendra , Meenakshi
Published: November 2024

In different types of industries, a lot of adhesives are used, which are harmful to living beings and are the main source of environmental pollution. Among inorganic adhesives, sodium silicate is very popular due to its excellent binding qualities. It is odorless, fireproof, non-toxic, and free from volatile organic compounds. It is affordable and simple to use, but its low water resistance limits its large-scale commercial utilization in the wood-based sector. To strengthen the link between teak wood and sodium silicate, three different sets of Na2SiO3 adhesive—pure Na2SiO3, modified Na2SiO3 by using silica gel G (as curing agent), and modified Na2SiO3, having different concentrations of shellac (2 -10%) were prepared in the present study. According to the findings, the best combination for tensile strength and moisture resistance is modified sodium silicate with 6% and 8% shellac, respectively. The FT-IR data demonstrated that shellac had effectively intermixed within the structure of the silicate and had good thermal stability in the 270– 8020C temperature range, which is also confirmed by the results of XRD, TGA, and DTG.
FORCED DEGRADATION STUDIES AND ASSESSMENT OF DEGRADATION PRODUCTS OF IMEGLIMIN HYDROCHLORIDE USING LC-ESI/APCI-MS
Authors: Talati A.S. , Dave H. N.
Published: November 2024

Forced degradation subjects drug substances to stress conditions, producing degradation products that are crucial for evaluating stability under accelerated conditions. Imeglimin hydrochloride is a commonly prescribed medicine for managing type 2 diabetes mellitus. This study details the forced degradation experiments and LC-MS analysis of degraded products of Imeglimin Hydrochloride under various stress conditions, offering insights into its stability and providing information on fragmentation pathways and major degradation products. The optimized mobile phase for the LC-MS method was composed of 10 mM ammonium format buffer (pH 3): methanol with a ratio of 75:25 v/v, obtained on an Xtimate C-18 column (flow rate of 0.8 ml/min), with 234 nm as the specific detection wavelength for Imeglimin Hydrochloride. The drug was subjected to stress conditions including photolysis, hydrolysis, thermal, and oxidative stress conditions. After various stress conditions were applied, the complete stability pathways and effects of these stress conditions were examined. Imeglimin hydrochloride underwent degradation when exposed to oxidative conditions at room temperature and basic conditions at elevated temperatures. However, specific degradation products were not found under acidic, thermal, and photolytic stress conditions. By comparing predicted and observed fragmentation patterns and identifying base peaks, LC-MS analysis of Imeglimin Hydrochloride revealed two new degradation products, DP1 (m/z 160.2) and DP2 (m/z 118.0) under oxidative and basic stress conditions, respectively. The developed method was validated as per the guidelines of analytical method validation.
On improving approaches to reducing earthquake damage
Authors: Shebalin P. N. , Tikhotskyb S. A. , Kovalenko A. A.
Published: November 2024

Catastrophic earthquakes have not occurred in Russia since the Neftegorsk earthquake of 1995. Almost 30 years of apparent calm do not mean, however, that such disasters will not occur in the coming decades. Over these 30 years, there have been about 10 earthquakes of comparable strength, but all of them were in sparsely populated areas of Kamchatka, the Kuril Islands, and Altai. The experience of recent earthquakes in Turkey and Morocco shows that the approaches to seismic hazard assessment and the system of using such assessments in construction adopted worldwide, including in Russia, need to be adjusted. The paper discusses the need to apply both a probabilistic approach to seismic hazard assessment, necessary for seismic risk calculations, and deterministic analysis methods that will allow moving to more reliable assessments for detailed seismic zoning in areas of possible catastrophic earthquakes and for the construction of important facilities. Seismic risk assessments have not previously been carried out on a national scale, but are necessary for the implementation of a disaster insurance system and prioritization of costs for strengthening buildings in seismically hazardous areas.
The article was prepared on the basis of a report heard at a meeting of the presidium of the RAS on June 11, 2024.
Migration losses and reproduction of the population of small and medium cities of north-west Russia
Authors: Vorobieva O. D. , Topilin A. V. , Ustinova V. A.
Published: November 2024

The article is devoted to the analysis of trends in two components of population change – its reproduction and migration in small and medium-sized cities in the north-west of European Russia (using the example of cities in the Vologda and Novgorod regions). Following the demographic compression of rural settlements and their disappearance, a similar process affect the small and medium-sized cities of the ancient cultural, historical and economic centers of Russia. The causes and consequences of socio-economic deformations of traditional Russian territories identified. It is proposed to reconsider key approaches to the development of the urban settlement network in the region, measures of stabilization of the population and labor resources, improvement of the age structure, and increasing the migration attractiveness of small and medium-sized cities.
The Impact of Digital Instability on Interface Design Research
Authors: Salyha Pavlo
Published: November 2024

Research Objective: To identify and systematize the factors affecting digital instability in interface research and to explore methods for preserving (archiving) user experience over time to improve the quality of scientific research in this field. Research Methodology: Analysis of previous studies related to digital instability and interface archiving, as well as a comparative analysis of current approaches to preserving digital content. Scientific Novelty. The factors influencing digital instability on interface and user experience research have been identified and systematized. For the first time, a comprehensive analysis of the problems associated with the disappearance and transformation of digital interfaces, which complicates their research in time, has been conducted. New methodological approaches to interface research that take digital instability into account have been proposed, including focusing research on the designer's work process, clear fixation of the date and version of the research subject, and methods for archiving the user experience of interactive interfaces. Conclusions: Digital instability complicates interface design research, as online and desktop products constantly change or disappear, which can lead to the loss of the research subject even before the scientific work is completed. To improve the quality of research, it is necessary to implement methods of partial archiving, fix important interface elements, and focus on the designer's work process. Archiving digital interfaces is important for preserving them in their original form, which may include saving mockups in stable formats such as PDF, creating screenshots, or recording videos of user interactions with the interface. It is important to clearly fix the date and version of the interface being studied to ensure the possibility of subsequent verification of the results.
Ethno-Design of Galicia at the Beginning of the 20th Century
Authors: Volynska Olena
Published: November 2024

The aim of the research is the factors and backgrounds formation of Galicia ethno-design at the beginning of XX century. The processes, which influenced the area of ethno-design development, have completely been spotlighted in the work. Its formation is being considered as the cultural event interrelated with the historic-economical, geographical, social-cultural changes in the region of the investigated period. Research methods: search-analytical (identification, literature analysis and origin foundation), historical (research of events and phenomena development), chronological (events consideration in the time consistency), logical-synthetic (factors, events and phenomena analysis), generalization and systematization results. Scientific novelty. In the research the backgrounds and features of regional manner-designed heritage formation have been revealed which are rooted in the unique folk art, folk art traditions, grand work of regional rules formation and stylization, ethno-pedagogics principles application in familial art upbringing, formation of private craft and art-industrial schools in the area, and so forth. Conclusions. As the result it has been concluded that the Galicia ethno-design at the beginning of the last century was characterized by the distinctive art and art-industrial traditions which influenced the unique Ukrainian style separation based on the West-European achievements. Different kinds of folk art, craft and homecraft played the important role in those processes. Through the nature forms and reasons stylization they gained their signs and colors semantics inherent of the area. The background of Galicia ethno-design development has become the esthetic tastes formation in family training of children and youth, ethno-pedagogical phenomenon of the regional art dynasties, foundation and performance of educational establishments with the national art-industrial culture of the area. It is highly important to use this experience in the professional training of Ukrainian designers.
PENGARUH SOCIAL MEDIA MARKETING, INSTAGRAM INFLUENCER DAN GREEN PRODUCT TERHADAP PURCHASE DECISION
Authors: Al Ahmadi Wahid Hidayat , Fadhilah Muinah , Maharani Bernadetta Diansepti
Published: November 2024

Dalam perkembangan transformasi digital yang sangat pesat saat ini membuat peran pemasaran bagi kelangsungan usaha bisnis menjadi sangat penting, strategi pemasaran yang dilakukan oleh pengusaha diharapkan mampu memunculkan rasa percaya pada konsumen yang dapat dibangun melalui media sosial, dengan menyediakan produk dan layanan yang inovatif yang memberikan rasa dan nilai sehingga menciptakan kepercayaan kepada pelanggan yang dapat mendorong keputusan pembelian (purchase decision). Pada penelitian ini penulis mencoba menganalisis pengaruh social media marketing, instagram influencer, dan green product terhadap purchase desicion studi kasus pada akun instagram laode.mci8. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh masing-masing variabel yaitu social media marketing (X1), instagram influencer (X2), dan green product (X3) terhadap purchase decision (Y). Dalam penelitian ini data dikumpulkan melalui metode kuesioner berjumlah 100 orang responden menggunakan metode purposive sampling untuk mengetahui tanggapan responden terhadap masing-masing variabel. Kemudian analisis terhadap data yang diperoleh berupa analisis kuantitatif yang meliputi uji validitas, dan reliabilitas, uji asumsi klasik, uji hipotesis, dan uji analisis koefisien determinasi (R2). Teknik analisis data yang digunakan adalah regresi linier berganda yang berfungsi untuk membuktikan hipotesis penelitian itu. Hasil analisis menunjukan bahwa variabel social media marketing, instagram influencer, dan green product mempunyai pengaruh positif dan signifikan terhadap purchase decision. Uji hipotesis dengan menggunakan uji t juga menunjukan bahwa ketiga variabel independen yang diteliti terbukti berpengaruh signifikan terhadap variabel dependen. Kemudian melalui uji F bisa terlihat bahwa variabel social media marketing, instagram influencer, dan green product berpengaruh simultan terhadap purchase decision. Angka kuadrat Adjusted R sebesar 0,485 menunjukan bahwa 48,5% variasi purchase decision dapat dijelaskan oleh tiga variabel independen yang digunakan dalam persamaan regresi. Sedangkan sisanya 51,5 % dijelaskan oleh variabel lain diluar ketiga variabel yang digunakan dalam penelitian ini.
Self-determination, vocational rehabilitation, and workplace	supports
Authors: Wehmeyer Michael L.
Published: November 2024

This article introduces the special issue on self-determination and vocational rehabilitation by defining the self-determination construct and examining its relevance to vocational rehabilitation services.
ARCHITECTURAL METHODS AND TECHNIQUES THERMAL ADAPTATION OF BUILDINGS IN HOT CLIMATE CONDITIONS
Authors: Osychenko Halyna
Published: November 2024

Protection from summer heat is a practical and scientific issue, which is becoming more and more relevant in Europe and Ukraine due to climate changes and long periods of heat. Heat protection measures have a positive effect on the microclimate of the building, insufficient protection increases energy costs for maintaining heat in the building in the winter and protection from heat in the summer. Therefore, when designing buildings, it is important to balance the protection of the building from the sun and cold, the insulation of the building with its connection with the external environment, to ensure the ventilation of the premises and to make the optimal choice of materials to ensure a comfortable climate in the premises and to minimize energy consumption. The study analyzed the global experience of applying measures to protect buildings from heat by means of thermoregulation. A classification of the means of thermal adaptation of the building from the heat has been carried out (architectural, planning, engineering and technical measures, landscaping, reservoirs and water systems, construction and decoration materials), among which architectural and planning measures are combined and often include all others.The work classifies the methods and techniques of thermal adaptation of the building on two large-scale levels: thermoregulation of the microclimate of the site and thermoregulation of the microclimate of the building directly. The main focus of the research is on "soft" methods and means, which are traditional natural and passive measures against building overheating in countries with hot climates.Their diversity is considered and classified as follows: methods of creating shadowy micro spaces, methods of reducing overheating of building and ground surfaces, methods of building insulation (minimizing communication with the external adverse environment) and methods of ensuring ventilation.
BASIC PRINCIPLES OF UNIVERSAL DESIGN AND BARRIER ACCESSIBILITY WHEN DESIGNING PUBLIC SPACES IN MODERN CONDITIONS
Authors: Pavlenko Tetiana , Lytvynenko Tetyana , Yenshuieva Tetiana , Pasichna Tetiana , Zubrychev Oleksandr
Published: November 2024

These research materials consider the main problems of barrier-free public spaces in modern conditions. The main conceptual directions of solving the problem of barriers at the domestic and international levels are analyzed. A thorough analysis of the existing state of public spaces at the elementary level was carried out. On the basis of the researched conceptual directions for solving the problem of barriers, the main principles of universal design and barrier-free design in the design of public spaces are defined: the use of public space on equal rights, the possibility of flexible use of public space, the simplicity and convenience of using public space, the possibility of receiving information without dependence on sensory capabilities of users of public space, the possibility of making mistakes, the lowest level of applied physical effort, as well as the presence of a public space of the required size.Thus, the design of the environment of public spaces and its elements should be carried out taking into account the needs of low-mobility population groups in order to create a space without barriers.Taking into account the principles of universal design and barrier-freeness when designing public spaces enables visitors to safely and comfortably use the environment of public spaces in modern conditions.
HISTORICAL STAGES OF DEVELOPMENT AND PROBLEMS OF PROVIDING ARCHITECTURAL ACCESSIBILITY OF SPORTS FACILITIES
Authors: Shkliar Svitlana , Zaitseva Anna
Published: November 2024

The work analyzes the relationship between the development of sports for people with disabilities and the formation of sports buildings accessible to people with reduced mobility. It was established that the development of sports and the involvement of people with disabilities was the primary factor in the development of sports facilities and centers adapted to the needs of people with disabilities. The formation of the architecture of sports facilities accessible to people with reduced mobility has become a secondary issue of this problem, aimed at ensuring the parameters of the subject-spatial environment and accessibility requirements for athletes with disabilities.The main stages of the history of the development of architectural accessibility of sports facilities and the characteristic features of each of the stages are determined. In the history of the development of architectural accessibility of sports facilities, three stages can be distinguished, each of which had its own characteristic features. The first stage (20-50s of the 20th century) – "clinical sports" – the introduction of sports into the system of medical rehabilitation and, accordingly, sports facilities into the structure of medical institutions; adaptation of existing facilities to the needs of people with disabilities. The second stage (60-90s of the XX century) – "professional sports" – the establishment of official international sports committees and competitions for people with disabilities, the holding of the Paralympic Games, the creation of new sports facilities for professional sports of people with disabilities. The third stage (from the beginning of the 21st century) – "sport for all" – the development of amateur sports; designing sports facilities on the basis of universal design with free and equal access for all categories of users, including people with disabilities.The main problems of ensuring the architectural accessibility of sports facilities for people with disabilities in Ukraine are analyzed. It was determined that the main problem of the development of adaptive and amateur sports in Ukraine is the "architectural inaccessibility" of sports buildings erected during the 20th century, during the times of the former USSR, when neither the issues of barrier-free architecture nor the issues of sports for people with disabilities were paid attention to. The majority of such sports buildings in Ukraine. Therefore, the most urgent issue today in the field of inclusive sports facilities is the analysis of accessibility conditions for people with disabilities in existing sports buildings, as well as the development of recommendations for their adaptation and reasonable adjustment.
BICYCLE IN CITY TRANSPORT INFRASTRUCTURE: FOREIGN EXPERIENCE
Authors: Danylenko Anna , Topal Svitlana
Published: November 2024

Development of the transport infrastructure of cities and increasing the mobility of citizens is an urgent task in today's world. Many capitals of the world, in search of solutions to transport problems and with the aim of improving the environmental situation, are actively promoting the use of bicycles when moving around the city. In the conditions of dense urban buildings and constant traffic jams, the bicycle is considered as a sustainable alternative means of transport.The purpose of this work is to study the experience of European cities in the field of bicycle infrastructure, and to develop proposals for their implementation.To achieve this goal, the following tasks have been set:- To consider the modern foreign practice of implementing bicycle infrastructure in the cities and megacities of the world;- Develop proposals for their application in the transport policy of Ukraine.The article examines the foreign experience of the development of bicycle traffic in cities and megacities. Based on the analysis, generalizations were made, as a result of which the peculiarities of the development and directions of bicycle transport infrastructure in large cities were highlighted.The obtained results indicate the great prospects and possibilities of using such examples of bicycle transport infrastructure in Ukraine, in particular in the city of Odesa, where, due to the growing motorization, the citizens are faced with existing problems.