bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Six Lobster Species of Genus Panulirus (Decapoda, Palinuridae) from Aceh Waters, Indonesia Based on Morphometric Analysis
Authors: Irfannur I. , Saputra S. , Muliari M. , Akmal Y. , Batubara A. S.
Published: April 2024

Aceh Province is a potential area for the exploitation of Panulirus, with six species of Panulirus inhabiting coastal areas and coral ecosystems in Aceh Province including P. homarus (Linnaeus, 1758), P. longipes (A. Milne Edwards, 1868), P. ornatus (Fabricius, 1798), P. penicillatus (Olivier, 1791), P. polyphagus (Herbst, 1793), and P. versicolor (Latreille, 1804). This study aims to characterise six species of Panulirus originating from Aceh as management and conservation efforts in the future. This research was conducted from 2022‒2023 at Simeulue Island (P. homarus, P. longipes, P. penicillatus, and P. versicolor) and Aceh Jaya Regency (P. ornatus and P. polyphagus), Aceh Province, Indonesia. The collected samples were then transported to the Aquaculture Integrated Laboratory, Almuslim University, Indonesia for further analysis. The collected lobsters were of mature size (body weight and total length reaching 500 g and 18‒25 cm) with a total of 10 individuals per species. A total of 58 morphometric characters were measured, of which total length (TL) was used as the coefficient of data transformation, so only 57 characters were subjected to statistical tests. Statistical analysis of the measured morphometric characters was performed using univariate ANOVA (analysis of variance) and multivariate DFA (discriminant function analysis) methods using SPSS Ver. 22. Univariate and multivariate morphometric analysis allowed the classification of six Panulirus species based on their specific characters. A total of 51 out of 57 morphometric characters were significantly different (P < 0.05), while only the six characters were not significantly different. Panulirus ornatus is the species with the highest species distance compared to the other five Panulirus species based on DFA analysis (scatter plot). Morphometric analysis to differentiate the six Panulirus species provides more comprehensive information on key morphological identification characters.
SISRES: Web-Based Culinary Recommendation with Collaborative Filtering
Authors: Aini Qurrotul , Muhammad Fadly Hakim , Rustamaji Eri , Thwe Yamin
Published: April 2024

Due to its advantageous location on the border of Jakarta and Tangerang, Tangerang Selatan is a highly developed city. In this instance, the Tangerang Selatan Department of Culture and Tourism (Dispar Tangsel) is required to use the application to assist the general public in realizing the availability of information in the Tangerang Selatan area. Twenty to twenty-five restaurants submit applications each year to the Dispar Tangsel Tourism Business Registry (TDUP). Dispar Tangsel must choose and decide on TDUP licensing priorities from among TDUP requests in order to open a restaurant. The purpose of the research is to offer recommendations to the community on food choices. Rapid application development (RAD) was used in the system's development. Additionally, the collaborative filtering technique has been employed by the decision support system to determine the amount of criteria or weight for restaurants using the weighted sum algorithm and for restaurants using cosine-based similarity algorithms. Additionally, the system design tool made use of MySQL as a database, PHP, the Codeigniter framework, and the unified modeling language (UML). The result demonstrates that the system is capable of displaying the output in accordance with the user's expectations during black box testing, which evaluates the functionality of the system based on the specifications. Collaborative filtering in SISRES can yield a significant improvement in recommendation accuracy. By collectively analyzing user preferences and behaviors, the algorithm can provide more relevant and personalized recommendations.
Incidencia de dedo flotante en la osteotomía metatarsiana distal percutánea con osteosíntesis para el tratamiento de la metatarsalgia con dedo en martillo rígido
Authors: Bilbao Facundo , Cafruni Virginia María , Cardone Guillermo , Villena Daniel Sebastián , Verbner Jonathan Maximiliano , Carrasco N. Marina
Published: April 2024

Introducción: La metatarsalgia central es una causa frecuente de dolor de antepié. La osteotomía de Weil es el tratamiento quirúrgico más popular y la osteotomía metatarsiana distal percutánea (OMDP) es la técnica percutánea más utilizada. La principal desventaja de estas técnicas es la aparición de dedo flotante que es aún mayor cuando se la asocia a artrodesis interfalángica proximal (AIFP). En esta serie de casos, se combinó la OMDP y la osteosíntesis con clavija de Kirschner para elevar el centro de rotación de la cabeza del metatarsiano con el objetivo de disminuir la presencia de dedos flotantes. Nuestra principal hipótesis fue que esta técnica generará menos dedos flotantes en los pacientes con diagnóstico de metatarsalgia mecánica y dedo en martillo rígido, comparada con la osteotomía de Weil.

Materiales y Métodos: Se realizó un estudio retrospectivo en pacientes adultos con diagnóstico de metatarsalgia mecánica y dedo en martillo rígido. Se los sometió a una OMDP más fijación con clavija de Kirschner en combinación con AIFP. Finalmente, se comparó la presencia de dedos flotantes con un grupo de pacientes operados con la técnica de Weil y AIFP.

Resultados: Se realizaron 39 OMDP más AIFP. La tasa de dedos flotantes fue del 31%. No hubo una diferencia estadísticamente significativa comparada con la técnica de Weil (36%, p = 0,634).

Conclusión: La OMDP con elevación del centro de rotación asociada con AIFP no proporcionó una menor incidencia de dedos flotantes en comparación con la osteotomía de Weil.
Dermotracción por bandas: estudio retrospectivo sobre su efectividad en el cierre diferido de defectos de cobertura en la pierna
Authors: Carranza Pablo , Krause Faustino , Otero Adali , Bottarelli José Luis , Plana Federico
Published: April 2024

Introducción: Una propiedad característica del tegumento humano es la viscoelasticidad. La piel y el tejido celular subcutáneo traccionados por una fuerza constante pueden llegar a cubrir áreas expuestas en lapsos relativamente breves. El objetivo de este estudio fue analizar una serie de casos con defectos de cobertura de la pierna. Se realizó la síntesis tegumentaria con técnica de dermotracción mediante “bandas de tracción”, con la finalidad de poder precisar qué lesiones pueden beneficiarse de este método.

Materiales y Métodos: Estudio retrospectivo, descriptivo, longitudinal realizado entre 2012 y 2019. Los criterios de inclusión fueron: 1) heridas con déficit de cobertura tegumentaria en la pierna, de etiología traumática diversa (dehiscencia de abordajes quirúrgicos, fasciotomías por síndrome compartimental, fracturas expuestas y heridas abiertas con déficit de partes blandas).Resultados: Se analizó a 36 pacientes (edad promedio 28 años) que tenían lesiones con pérdida de cobertura localizadas en distintas regiones de la pierna. En 27 pacientes (75%), se logró el cierre sin necesidad de procedimientos complementarios. En el 8,3%, se logró la reducción del área expuesta y fue necesario un procedimiento complementario (injerto de piel). Seis pacientesrequirieron técnicas reconstructivas de partes blandas miocutáneas y fasciocutáneas.

Conclusiones: Esta técnica es efectiva, simple y económica para lograr el cierre diferido de las heridas complejas o fasciotomías. La dermotracción permite el cierre diferido en pocos días luego del trauma.
Luxación periastragalina posterior genuina cerrada sin fractura ni mala alineación asociada. Reporte de un caso y revisión bibliográfica
Authors: Romero Ante Juan Manuel , Rosero Cabrera Sebastián
Published: April 2024

La luxación periastragalina es un tipo de luxación infrecuente. Se clasifica según la relación del calcáneo con respecto al astrágalo, y las más comunes son las formas medial y lateral; y hay casos aislados de las variantes posterior y anterior. Presentamos el caso de un paciente con una luxación periastragalina cerrada posterior sin fractura asociada, el video de la técnica para la reducción cerrada bajo anestesia y también una revisión bibliográfica de esta infrecuente variedad de luxación.
SAMeCiPP: pasado, presente y futuro de una Sociedad pionera en la subespecialización
Authors: Segura Florencio Pablo
Published: April 2024

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Chemical-Mechanical Agents Versus Rotary Systems for Caries Removal: A Systematic Review of In Vitro Studies
Authors: Quiroz-Reynoso Josselyn Myriam , Mungi-Castañeda Sabina , Marroquín-Soto Consuelo , Carranza-Samanez Kilder Maynor , Dulanto-Vargas Julissa Amparo
Published: April 2024

The purpose of this systematic review was to compare the efficacy and efficiency of chemical-mechanical agents (CMA) versus rotary systems (RS) for the removal of dental caries (DC) in permanent molars. The search was carried out in five electronic databases (PubMed, Ebsco, Scopus, ScienceDirect, LILACS) and gray literature, complemented with a manual search in impact journals until July 2022 in English, Spanish and Portuguese. The efficacy of DC treatment was analyzed histologically, microbiologically, radiographically, or physicochemical-mechanically and efficiency was evaluated according to the shortest time for removal. Risk of bias was assessed with the RoB tool. Nine studies were included out of 914 publications that evaluated 337 molars with split design treated with low- or high-speed RS and CMA, such as Carisolv, Papacarie, Carie Care and Brix 3000. Significant differences were found among the studies (p<0.05), with Carisolv presenting a higher amount of residual caries, the presence of bacteria in dentin and less extent or volume of extracted caries, while Papacarie showed an absence of smear in dentin tubules and RS obtained higher microhardness values and required less time for removal. There was no difference between the two methods with respect to calcium-phosphorus titration or bond strength (p≥0.05). CMAs removed DC with less invasion to sound dentin tissues compared to RS, but reduced surface hardness and required a longer removal time.
“Few of the many returned home”
Authors: Nudell Joshua
Published: April 2024

Histories of the Sicilian Expedition usually focus on Athens, and with good reason: Athens supplied the largest number of ships, all the leaders were Athenians, and Thucydides' account is constructed as an Athenian tragedy that largely subsumes the allies into the crowd of soldiers. Moreover, it was in the aftermath of the disaster that the Aegean poleis slipped through the Athenian grasp. Scholars have offered explanations for the outbreak of the Ionian War that range from anti-Athenian sentiment stemming from wartime measures like the Standards Decree that primed the Athenians to reject Athenian hegemony to a change in Persian policy to an ephemeral mood. When they invoke Sicily, it is to follow Diodorus Siculus in arguing that the failure created contempt for Athenian hegemony (τὴν ἡγεμονίαν αὐτῶν καταφρονηθῆναι, 13. 34. 1). Another cause of the Ionian War, however, has received too little attention: the Ionians who fought in Sicily. In this paper I re-evaluate the Sicilian Expedition from the perspective of the non-Athenians, and particularly the Ionians. These contributions have traditionally been underestimated because Thucydides implies that they had fallen out of practice with warfare and were thus complicit in their own subjugation. Nevertheless, Thucydides' history is littered with accounts of Ionian soldiers fighting far from home, up to and including in the Sicilian Expedition (Thuc. 7. 20. 2; 7. 57. 3). Re-evaluating the evidence for Ionian contributions to the Athenian war effort in turn complicates straightforward assessments of the popularity of the empire and opens the possibility that it was not only Athenian weakness but also the costs borne by the allies that led the Ionians to put in motion the events that led to revolt.
A creative industries perspective on open strategy drivers
Authors: Radomska Joanna , Wołczek Przemysław , Hajdas Monika , Klimczak Mikołaj
Published: April 2024

Open strategy is a widely discussed research area, including the themes of organization design, open innovation, and open business models. However, the contextual perspective to analyse this concept is scarce. This paper addressed this issue by providing a framework highlighting a set of drivers that may affect transparency and inclusiveness as dimensions of open strategy and proposed these drivers by exploring the context of the creative industries representing the activities that differ in their business ecosystem. However, they are very similar in some respects (e.g., generating ideas, imagination, copyrights, intellectual property). These similarities make it interesting to bring the CI as the context for investigating industry factors that impact the strategy’s opening to understand the drivers that may hinder or foster its implementation. The authors believe the proposed framework could guide the decision-making process by providing the unfavourable and conducive drivers that might affect open strategy implementation.
Counting on The Norton Anthology of American Literature
Authors: Fredner Erik , Porter J. D.
Published: April 2024

We created a relational database that captures every author and work ever selected for The Norton Anthology of American Literature. Given this anthology's influence, our database reveals changes in the literary canon over the past half century. We find that the common story of increased diversity is true, albeit truer with respect to race than gender. However, the biggest structural change has been a substantial growth in the number of anthologized authors. We argue that, while that strategy has produced real gains, it also creates a canon that less effectively manages reader attention, affords women and people of color a less valuable position than many white male authors once enjoyed, and tacitly accepts the notion that the new additions do not have greater literary merit than authors on the original roster, whom we show editors too rarely cut.
Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells
Authors: Maxwell Scott , Okabe Jun , Kaipananickal Harikrishnan , Rodriguez Hanah , Khurana Ishant , Al-Hasani Keith , Chow Bryna S.M. , Pitsillou Eleni , Karagiannis Tom C. , Jandeleit-Dahm Karin , Ma Ronald C.W. , Huang Yu , Chan Juliana C.N. , Cooper Mark E. , El-Osta Assam
Published: April 2024

Key Points

Set7 knockout improves diabetic glomerular structure and function and prevents diabetes-induced endothelial–mesenchymal transition (EDMT) by regulating Igfbp5.

Set7 knockdown prevents, and (R)-PFI-2 hydrochloride reverses, diabetes-induced EDMT by regulating insulin growth factor binding protein 5.

Set7 regulates the phenotypic EDMT switch, and inhibiting the methyltransferase attenuates glomerular injury in diabetic kidney disease.

Background

Hyperglycemia influences the development of glomerular endothelial cell damage, and nowhere is this more evident than in the progression of diabetic kidney disease (DKD). While the Set7 lysine methyltransferase is a known hyperglycemic sensor, its role in endothelial cell function in the context of DKD remains poorly understood.

Methods

Single-cell transcriptomics was used to investigate Set7 regulation in a mouse model of DKD, followed by validation of findings using pharmacological and short hairpin RNA inhibition inhibition of Set7.

Results

Set7 knockout (Set7KO) improved glomerular structure and albuminuria in a mouse model of diabetes. Analysis of single-cell RNA-sequencing data showed dynamic transcriptional changes in diabetic renal cells. Set7KO controls phenotype switching of glomerular endothelial cell populations by transcriptional regulation of the insulin growth factor binding protein 5 (IGFBP5). Chromatin immunoprecipitation assays confirmed that the expression of the IGFBP5 gene was associated with mono- and dimethylation of histone H3 lysine 4 (H3K4me1/2). This generalizability was investigated in human kidney and circulating hyperglycemic cells exposed to TGFβ1. We showed that the highly selective Set7 inhibitor (R)-PFI-2 hydrochloride attenuated indices associated with renal cell damage and mesenchymal transition, specifically (1) reactive oxygen species production, (2) IGFBP5 gene regulation, and (3) expression of mesenchymal markers. Furthermore, renal benefit observed in Set7KO diabetic mice closely corresponded in human glomerular endothelial cells with (R)-PFI-2 hydrochloride inhibition or Set7 short hairpin RNA silencing.

Conclusions

Set7 regulates the phenotypic endothelial–mesenchymal transition switch and suggests that targeting the lysine methyltransferase could protect glomerular cell injury in DKD.

Podcast

This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2024_04_25_ASN0000000000000345.mp3
FORMING THE IMAGE OF THE MIXER IN THE COMPLEX FOR THE PRODUCTION OF SYNTHESIS GAS DEPENDING ON THE PRODUCTIVITY
Authors: Tseneva Sofiia N. , Kuzmin Aleksey M. , Morozova Ekaterina S.
Published: April 2024

The problem of shaping the image of a mixer in a synthesis gas production complex depending on productivity is discussed in the article. The main task is to justify the choice of a structural element for effective mixing of components in a small-scale synthesis gas production complex with a productivity of up to 5000 tons per year. Optimal conditions for each unit of the complex are being developed in order to ensure the quality performance of the individual block and to change the appearance of the mixing formation unit. The concept of creating mobile, transportable small-scale methanol production complexes, providing the necessary amount of product directly at the extraction site is discussed in the paper. The following requirements for these complexes are considered: mobility, transportability, work reliability in extreme conditions, small size, integration into infrastructure, maximum automation. In the context of this study, the processes of mixing components in the mixer, which allows us to define the quality picture of component mixing, overall dimensions, and appearance of the node itself are evaluated. Detailed analysis of the mixing processes in the mixer is carried out and its structure and functions are studied in depth. The paper presents a detailed analysis of the scheme, performed by iterative calculation of each element in the block under certain conditions and restrictions. The results help to identify the influence of productivity on the complex as a whole and on a specific node. This study will help specialists better understand optimal design and operation strategies for mixers for the production of synthesis gas. The article deepens the understanding of structural analysis in the context of choosing the most suitable structural element for effective component mixing.
EXPERIENCE IN IMPLEMENTATION OF CROSS DISCIPLINARY TRAINING ON OCCUPATIONAL SAFETY
Authors: Fedosov Artem V. , Musin Robert R. , Panin Semen S. , Tumanova Elena Yu.
Published: April 2024

The relevance of this article is related to the mandatory training in labor protection to meet the qualifications of specialists. The scientific article highlights the problem of the ineffectiveness of occupational safety training, focused exclusively on theoretical knowledge without a practical component. Lack of practice limits the application of theoretical knowledge in real situations, which leads to insufficient safety in the workplace. The relevance of the article is emphasized by the mandatory nature of occupational safety training and its importance for improving working conditions. Cross-disciplinary training is proposed as a solution to the problem, facilitating the exchange of experience, improving communication and developing collective skills. For optimal results in the field of occupational safety, it is proposed to develop cross-disciplinary training programs with a practical component.Program of additional professional education «Occupational Safety and Health. Workshop», developed jointly by the Federal State Budgetary Educational Institution of Higher Education «Ufa State Petroleum Technical University» and PJSC «Gazprom Neft», is a practical step in solving the identified problems. Analysis of the results, study of standards and interviews with the target audience of the training made it possible to create a program aimed at developing not only theoretical, but also practical skills necessary to ensure safety in the workplace.As a result, the implementation of such programs will be a key step in improving the skills of workers, ensuring occupational safety and minimizing the risk of accidents at work. The transition to cross-disciplinary training in occupational safety and health is a vector for further research and development, which is important not only from a practical, but also from a socio-economic point of view.
¿Cómo formar al profesorado en pensamiento computacional? Validación del Modelo 5PC
Authors: Serrano García Noemí Carmen , Serrano José Luis
Published: April 2024

Los nuevos currículos escolares incluyen la educación del pensamiento computacional del alumnado. Esto genera la necesidad de formar adecuadamente a los docentes, asunto que todavía presenta ciertas limitaciones. Una de ellas ha sido la ausencia de marcos pedagógicos adecuados. El diseño del Modelo 5PC trata de cubrir esta necesidad estableciendo cinco pasos secuenciales de enseñanza-aprendizaje del pensamiento computacional, que van activando distintos elementos a la vez que se desarrollan procesos de resolución de problemas. Sin embargo, este Modelo no cuenta con suficientes experiencias de implementación y evaluación. El objetivo de este estudio es someter este Modelo a juicio de expertos mediante el método Delphi, con el fin de validarlo y mejorarlo. Se realizaron dos rondas de preguntas en las que participaron seis expertos de distintas universidades. Tras el análisis de sus respuestas, se modificaron distintos elementos del Modelo 5PC, tales como: las fases del proceso de enseñanza-aprendizaje, las fases del proceso de resolución de problemas y en la distribución de los métodos y habilidades transversales.
Uso de los medios sociales por los docentes universitarios españoles de traducción e interpretación
Authors:   Universidad Internacional de Valencia, Cedillo Corrochano Carmen
Published: April 2024

Expertos en la materia llevan años reivindicando la necesidad de que el profesorado universitario tome consciencia de las posibilidades educativas de los medios sociales o social media, y las aplique adecuadamente en sus aulas para afrontar los retos pedagógicos presentes y futuros. Desde entonces, no han cesado las publicaciones que responsabilizan al profesorado universitario de no usar todo el potencial de estas tecnologías de la información y la comunicación para mejorar los procesos de aprendizaje y conocimiento de sus estudiantes y su inmersión en el mundo profesional. Sin embargo, si bien se ha sometido a análisis el uso de los medios sociales por los docentes de distintos grados o posgrados, hasta la fecha no se ha llevado a término ninguno que evalúe el comportamiento de los formadores de traductores e intérpretes a este respecto. Por ello, el presente trabajo explora los conocimientos que poseen los docentes del grado en Traducción e Interpretación de distintas universidades españolas sobre los medios sociales, el tratamiento que les dispensan en su vida personal y en su ejercicio docente, y la opinión crítica que sustentan sobre la importancia/utilidad de estas plataformas para los traductores e intérpretes, y para los mercados laborales actuales de traducción e interpretación. Así pues, revela novedosamente los resultados de un cuestionario de elaboración propia, cumplimentado por 50 profesores que imparten clases de traducción o interpretación en los grados de 18 universidades españolas. Las conclusiones delatan una necesidad (in)formativa sobre los medios sociales por parte del profesorado, que debería cubrirse para preparar a los estudiantes a adaptarse a las exigencias de los mercados de trabajo en los que se insertarán al finalizar sus estudios.
Comparative analysis of resection boundaries depending on the defect elimination method in oral mucosal cancer
Authors: Musin Sh. I. , Menshikov K. V. , Sultanbayev A. V. , Sharifgaleev I. A. , Ilyin V. V. , Guz A. O. , Rudyk A. N. , Osokin S. V. , Sharafutdinova N. A. , Chashchin A. V. , Garev A. V. , Baymuratov T. R.
Published: April 2024

Introduction. Surgical intervention remains the main method for treatment of the oral mucosa cancer. The generally accepted standard of the resection boundary that provides optimal local control is 5 mm. Adequate boundaries of indentation and choice of the reconstruction method are important issues facing specialists in head and neck tumors.

   Aim. To evaluate parameters of the resection edge in the surgical treatment of malignant neoplasms of the oral mucosa depending on the method of eliminating of the post-resection defect and its effect on the frequency of local relapse.

   Materials and methods. A retrospective analysis included 168 primary patients (50 % men and 50 % women) who received surgical treatment in the head and neck tumor department of the Republican Clinical Oncology Dispensary of the ministry of Health of the Republic of Bashkortostan (ufa) from 2019 to 2023. The median age of patients was 63 years (interquartile range (IQR) 55–69 years). most often, the primary tumor was located in the tongue – in 59.5 % (100/168) of cases. According to the method of post-resection defect removal, the patients were divided into 3 groups. In group 1, reconstruction was performed with local tissues (n = 71), in group 2 – with pedicle flaps (n = 41), and in group 3 – with revascularized flaps (n = 56). The median follow-up period was 18 months (IQR 8–28 months).

   Results. Resection boundaries in group 1 were 7.0 mm (IQR 5.0–12.5 mm), in group 2 – 6.5 mm (IQR 5–13 mm), and in group 3 – 12.5 mm (IQR 7.5–15.0 mm). The overall frequency of near/positive resection boundaries was 14.8 % (25/168). In group 1, it was 15.5 % (11/71), in group 2 – 19.5 % (8/41), in group 3 – 10.7 % (6/56). According to the analysis, relapse of the disease after radical treatment was noted in 32 % (55/168) of patients, of which 14.8 % (25/168) had a local relapse, 12.5 % (21/168) had a regional relapse, and 5.4 % (9/168) developed distant metastases. The frequency of local relapse in group 1 was 18.3 % (13/71), in group 2 – 23.8 % (10/41), in group 3 – 5.5 % (3/56). According to the analysis data, statistically significant differences in the boundary of indentation in the groups were revealed depending on the reconstruction method (p = 0.005).

   Conclusion. Based on the results of the present retrospective analysis, the choice of reconstruction method affects the resection boundary in real clinical practice. Limitations in the surgical indentation that surgeon faces when choosing a method for eliminating a post-resection defect are demonstrated.
The importance in clinical practice of the signal lymph node biopsy in squamous cell carcinoma of the head and neck
Authors: Gelfand I. M. , Kropotov M. A. , Isaeva M. T. , Podvyaznikov S. O.
Published: April 2024

Skin cancer is the second most common tumor among non-melanoma malignant skin neoplasms, accounting for 20 % of cases. In the Russian federation in 2022, this pathology was identified in 79,124 people. The peak incidence occurs in the age range of 60–70 years. Considering the increasing life expectancy, the incidence of skin cancer is expected to rise. Despite the fact that regional metastases occur in 0.3–16 % of cases, the risk of metastasis can increase up to 48 % depending on high-risk factors. Since the presence of regional metastases is a key prognostic factor, special attention should be given to preventive interventions in the areas of regional metastasis.
From the history of development of departments of medical service for head and neck tumors
Authors: Svetitsky P. V. , Goncharova E. G.
Published: April 2024

The article presents the history of development of otorhinolaryngology, a medical service associated with the head and neck tumors, as well as head and neck medical departments. The need for treatment of patients with malignant neoplasms in specialized oncological institutions is shown. Analysis of literature data, doctors’ speeches at various scientific conferences and personal contact with specialists in the head and neck cancers from Russia and countries – former republics of the USSR confirms the need for existence of the head and neck tumor departments.
Ultrasound diagnostics: assessment of tumor thickness and depth of invasion in squamous cell carcinoma of the oral cavity
Authors: Allakhverdieva G. F. , Dronova E. L. , Danzanova T. Yu. , Bacev A. F. , Pak M. B. , Kamolova F. Sh.
Published: April 2024

Aim. To evaluate the capabilities of ultrasound using various approaches in determining the depth of invasion of squamous cell carcinoma of the oral cavity and to compare the results obtained with data obtained by the use of other diagnostic methods.

   Materials and methods. In our reserch, ultrasonography was performed on 193 patients with primary malignant tumors of the mobile part of the tongue, floor of the oral cavity and tumors of rare locations (mucous membranes of the lip, cheek, alveolar processes). The age of the patients ranged from 15 to 85 years. In all patients, tumors were squamous cell carcinoma. ultrasound was performed using submandibular, intraoral and transbuccal approaches. ultrasonic data were compared with the results of pathomorphological examination, as well as of X-ray computed tomography and of magnetic resonance imaging with contrast.

   Results. A statistically significantly high correlation was obtained for all ultrasound approaches (submandibular, intraoral and transbuccal) with the depth of invasion of the oral tumor determined pathomorphologically (r = 0.78; r = 0.89; r = 0.93; p <0.001). Ultrasound using all approaches shows statistically significantly better results in determining the thickness of tumorsof the tongue and mouth floor in comparison with X-ray computed tomography and magnetic resonance imaging (p <0.001). All diagnostic methods are characterized by an overestimation of the tumor invasion depth (overdiagnosis) as compared with pathomorphological examination. for exophytic tumors and oral cavity tumors of mixed growth with an exophytic component, the depth of invasion was less than the tumor thickness.

   Conclusion. Ultrasound is an accessible, easily reproducible, radiation-free method, the resolution of which makes it possible to accurately determine not only the depth of invasion of oral tumors, but also the distance from the tumor to the midline of the tongue, that represents an important information when choosing the extent of surgical intervention.
Low expression of the ST6GAL2 and CD248 genes as an unfavorable prognostic marker of oral squamous cell carcinoma
Authors: Fedorova I. K. , Kolegova E. S. , Prostakishina E. A. , Dampilova T. D. , Patysheva M. R. , Yamshchikov P. S. , Denisov E. V. , Choynzonov E. L. , Kulbakin D. E.
Published: April 2024

Introduction. Squamous cell carcinoma (SCC) of the oral cavity is an aggressive and rapidly progressing disease. The tendency to progression of the tumor process is due to the clinical and pathological characteristics of the patient and the biological characteristics of the tumor. molecular and genetic disorders related with transcriptome level play an important role in tumor progression, which can be used in predicting the outcome of the disease.

   Aim. To identify markers for assessing the risk of the SCC progression.

   Materials and methods. Based on the data of the Cancer genome Atlas database, a bioinformatic search for genes associated with the progression of SCC was performed (11 genes were selected). Then we performed a retrospective analysis of clinical data and histological material from 38 patients with SCC treated at the Scientific Research Institute of Oncology of the Tomsk National Research medical Center of the Russian Academy of Sciences from 2018 to 2021. Fixed samples of tumor tissue were examined. The level of gene expression was determined by real-time quantitative polymerase chain reaction.

   Results. It was shown that decrease in the ST6GAL2 matrix RNA level is associated with presence of lymphogenic metastases and decrease in the CD248 matrix RNA level is associated with the occurrence of relapses.

   Conclusion. Expression level of the ST6GAL2 and CD248 genes can be used as predictors of an unfavorable prognosis of SCC.
Exploring ECG Signal Analysis Techniques for Arrhythmia Detection: A Review
Authors: Sandhya Samant Et al.
Published: April 2024

The heart holds paramount importance in the human body as it serves the crucial function of supplying blood and nutrients to various organs. Thus, maintaining its health is imperative. Arrhythmia, a heart disorder, arises when the heart's rhythm becomes irregular. Electrocardiogram (ECG) signals are commonly utilized for analyzing arrhythmia due to their simplicity and cost-effectiveness. The peaks observed in ECG graphs, particularly the R peak, are indicative of heart conditions, facilitating arrhythmia diagnosis. Arrhythmia is broadly categorized into Tachycardia and Bradycardia for identification purposes. This paper explores diverse techniques such as Deep Convolutional Neural Networks (CNNs), Long Short-Term Memory (LSTM), Support Vector Machines (SVM), Neural Network (NN) classifiers, as well as Wavelet and Time–Frequency Transform (TQWT), which have been employed over the past decade for arrhythmia detection using various datasets. The study delves into the analysis of arrhythmia classification on ECG datasets, highlighting the effectiveness of data preprocessing, feature extraction, and classification techniques in achieving superior performance in classifying ECG signals for arrhythmia detection.
Baseline Correction of Ground Motions for Linearly Detrended Accelerograms
Authors: Tian Shengze , Alam M. Shahria
Published: April 2024

By revisiting the accelerograms from 42 strong-motion stations in Hualien County that recorded the 2018 Mw 6.4 Hualien earthquake, we identified that the released “raw accelerograms” were linearly detrended to remove baselines. Baseline correction for these linearly detrended accelerograms is challenging, because the baseline drift patterns are more complex than typically recognized ones. To deal with this problem, here we propose a jerk correction pattern in addition to our previously proposed tilt correction pattern and cumulative correction pattern. The modified baseline correction procedure corrects all 126 accelerograms for three directions of the 42 strong-motion stations. The recovered ground displacements are consistent with geodetic measurements, demonstrating complex surface deformations in the close vicinity of the Milun fault.
East Prussia – About What Was and No Longer Is. Travel and Travelogue as a Bridge between Past and Present
Authors: Górajek Anna
Published: April 2024

This paper is devoted to an analysis of the travel reportages of German authors, which were written as a result of contemporary journeys to north-eastern Poland. The aim is to examine to what extent a journey to Poland, to the regions of Warmia and Masuria, is at the same time a journey to the lost landscapes of East Prussia, to what extent the past is present in the travel reports, and to what extent the travel reports evoke and revive what has disappeared.
History, Culture and Memory in the Novel "Grunowen oder Das vergangene Leben" by Arno Surminsk
Authors: Łyjak Konrad
Published: April 2024

Arno Surminski is a writer who was born in the former German province of East Prussia. His life and tough experiences at the end of World War II had an enormous influence on his literature. The novels of Surminski are not only full of references to his biography, but they are also the author’s commentary to lots on many other topics, e.g. the evacuation of East Prussia due to fear of the Red Army, the forced displacement of German civilians, the deportation to Siberia or mass rapes committed by the Soviet Army. The aim of the article is to analyse the novel Grunowen oder Das vergangene Leben by Arno Surminski not only as a literary fiction in the form of a travel novel, but most of all as Surminski’s contribution to the discussion about the history and culture of East Prussia.
Psychogeographical Walks with Paul Scraton and his Walk Book "On The Edge: Berlin Outskirts"
Authors: Kałążny Jerzy
Published: April 2024

Paul Scraton, born in 1979 in England, has lived in Berlin since 2001. He is the author of several books about different areas of Germany (e.g. the Baltic coast and Berlin) and the editor of the online-magazine Elsewhere. A Journal of Place. His travel book Am Rand: Um ganz Berlin includes descriptions of the outlying districts and reflections on his emotional relationship to these areas made on 10 walks along the Berlin city border. Scraton’s narratives are largely based on contemporary psychogeography as the method of exploration of the urban environments with special reference to personal connections to spaces and places called borderlands, edgelands and non-places. The article presents the reconstruction of the urban landscape outlined in Scraton’s book and reflections on the representational potential of the concept of psychogeography.
Complicaciones de la laringectomía total: experiencia de 7 años en un hospital universitario de Paraguay
Authors: Lugo Pla Humberto Joaquín , Solís Núñez Héctor Daniel , Giménez Almeida Santiago Marcelo , Benítez Ana Alicia María , Mena Canata Carlos Enrique
Published: April 2024

Introducción: El cáncer de laringe es la neoplasia maligna más común de las vías aerodigestivas superiores. La laringectomía total es el tratamiento de elección en casos avanzados, pero se asocia a una alta tasa de complicaciones. Objetivos: Conocer la prevalencia de las complicaciones posquirúrgicas de la laringectomía total y los factores asociados en pacientes con cáncer de laringe. Materiales y métodos: Estudio observacional, descriptivo, retrospectivo, de corte transversal, revisando el comportamiento de la laringectomía total y sus principales complicaciones en la Cátedra y Servicio de Otorrinolaringología del Hospital de Clínicas de la Facultad de Ciencias Médicas de la Universidad Nacional de Asunción, Paraguay, de 2015 a 2022. Se incluyeron pacientes mayores de 18 años, de ambos sexos, postoperados de laringectomía total, con diagnóstico anatomopatológico de neoplasia de laringe. Se excluyeron pacientes no operados, con fichas incompletas o que abandonaron el tratamiento. Se analizaron variables demográficas, clínicas, quirúrgicas y anatomopatológicas. Resultados: Se incluyeron 10 pacientes, todos varones, con edad media de 56,3 ± 10,2 años. El 90% presentaba hábitos tóxicos. La complicación más frecuente fue la fístula faringocutánea (70%), seguida por infección del sitio quirúrgico (10%) y sangrado posoperatorio (10%). El 71,4% de las fístulas se resolvieron con medidas conservadoras. El 30% tenía afectación supraglótica y el 57,1% de los que presentaron complicaciones recibieron radioterapia previa. Conclusión: Las complicaciones de la laringectomía total son frecuentes, principalmente la fístula faringocutánea. La afectación supraglótica y la radioterapia previa se asociaron a mayor tasa de complicaciones. Se requieren estudios prospectivos con muestras más grandes para confirmar estos hallazgos.
Pie diabético tratados con injerto obtenido por bioimpresora, a propósito de una serie de casos
Authors: Rivas Martínez Noelia , Salcedo Rodríguez Gabriela , Olmedo Florenciañez Eugenia , Duarte Centurión Kevin , Portillo Zena Laura , Rojas Báez Elías , Chaparro Santacruz Daisy , Barreto Machuca Viviano , Escudero Losanto
Published: April 2024

El riesgo de amputaciones en pacientes con diabetes es 10 a 20 veces más frecuente en comparación con no diabéticos. El equipo biotecnológico desarrollado por ROKIT Healthcare, Inc., de procedencia surcoreana: Dr. INVIVO, es un equipo de biotecnología que ofrece una terapia eficaz para el tratamiento del pie diabético, con una plataforma de regeneración de órganos hiperpersonalizados que mediante la inteligencia artificial, escanea la lesión para así, fabricar un parche que contiene células madres autólogas, matriz extracelular y materiales específicos de tejido, para posteriormente aplicarla a la herida, y con esto, lograr la cicatrización y regeneración completa. El propósito del presente reporte apunta a demostrar la efectividad del tratamiento en úlceras en pie diabético y exponer los resultados de 3 casos clínicos con extensas lesiones posteriores a amputaciones de miembros inferiores, atendidos en el Hospital Distrital de Ñemby, Paraguay, utilizando esta tecnología.
Applied Social Scientific Methods for the Measurement of Local Innovation Potential
Authors: Szabó-Tóth Kinga , Papp Z. Attila
Published: April 2024

The study introduces a methodological tool for measuring local social innovation potential and its application in five settlements in the Abaúj region of northeastern Hungary. When working on the local innovation potential (LIP) index we present in this study, we drew upon existing theories and models of social innovation. The complexity of LIP index comes from the fact that it builds upon both qualitative and quantitative data and research methods. Therefore it is simultaneously based on social scientific methods that are traditionally considered “soft” and “hard”. The LIP index is can take into account local specificities and characteristics into account and is thus suitable for presenting a fine-tuned description of the current situation and characteristics of a settlement, together with its future potential and directions for development.
Novel Fuzzy Reinforcement Algorithm for Mobile Robot Navigation in Automated Storage
Authors: Riman Chadi F. , Abi-Char Pierre E.
Published: April 2024

Robots are used to move stored items in Automated Storage (AS) to shelve and pickup items in warehouse depicted shelves. In this situation and many others, it is important to follow the shortest way so that the smallest time possible is taken to achieve the task. In this research, a Fuzzy Logic system with Q-Learning Reinforcement in order to achieve a better overall system. While Fuzzy Logic can be used alone for robot navigation, Reinforcement learning helps to adjust the fuzzy rules and refine them towards two main purposes: reach the final goal, while avoiding difficult obstacles such as traps. This is done as an enhancement on our previous work where Fuzzy Logic system was used alone. Simulation results are added to support the work done. It proved that this new system is much better than the previous one. Highlighting key parameters or features of simulation results show that the system achieved 33% more optimized time in addition to avoid stalled/unsuccessful navigation in some difficult situations, thus demonstrating the system’s success.
Campylobacter infections in Middle Eastern children: Review article
Authors: Al-Haddad Ahmed M. , Matran Yasser M. , Omer Abdullah O. Ba
Published: April 2024

() infections among children have become an alarming challenge for developed and developing countries. This narrative review highlights the concerning situation of and its antimicrobial resistance among Middle Eastern children. The review targeted studies on infections in the Middle East, focusing on those publications that were conducted within the past 14 years. The selected publications were sourced from the Google Scholar and PubMed databases. There was scanty published data addressing compylobacteriosis and its antimicrobial profile specifically among Middle Eastern children. Although there has been international concern about the role of and in causing childhood diarrhea, many regions in the Middle East do not appear to share the same level of concern. Furthermore, the complex interplay of socio-demographic and environmental elements that may influence infections, coupled with the globally rising concern over antibiotic resistance in spp (particularly multidrug-resistant strains), raises significant concerns in this region. Moreover, the presence of co-infections with , known to worsen disease severity, could exacerbate the issue and place a greater burden on healthcare systems. Additionally, the low awareness and insufficient prioritization of this public health issue, compounded by political conflicts in parts of the Middle East, present multiple challenges for children in several regions of the Middle East. These challenges, along with the consequences of late sequelae from infection, put many children in this region at significant risk. To effectively tackle these challenges, critical targeted interventions must be implemented. These interventions include conducting comprehensive epidemiological studies to understand the burden of in Middle Eastern children, characterizing the antibiotic susceptibility patterns of prevalent strains, updating healthcare practices to align with prevailing resistance profiles, adopting appropriate antibiotic prescription policies, and implementing robust infection control measures in this specific population.
Occurrence of nosocomial multi-drug resistant Klebsiella pneumoniae in India: A systemic review and meta-analysis
Authors: Lodhi Md. Mudassar Iqbal , S A Lakshminarayana , G.P Aaftab
Published: April 2024

The continuous rising of hospital acquired Multi Drug resistant creates an alarming condition in public health worldwide. Objective of this study is to identify quantitative analysis of hospital acquired Multi-Drug resistant in India.

Data were collected from Pub Med and Google scholar specific study of India to identify prevalence of Multi-drug resistant nosocomial starting from 2011 to 2023. Literature review were collected and analysed through Preferred reporting Items for Systematic Reviews and meta-analysis (PRISMA) guideline and SPSS- 25 software used for Data analysis. Meta-analysis report reveals that prevalence of multi-drug resistant among hospital acquired is 34.37 % and pooled prevalence rate of hospital acquired multi drug resistant infection found at 2 % (97.5 % CI, 2.5) with p-value is 0.01. Genotypic analysis reveals bla gene identified most among the studied samples.

Prevalence of ESBL, MDR associated with nosocomial infections estimated and correlated with mortality and death ratio as well as antibiotic susceptibility tests pattern was analysed in India which shows continuous rising number of MDR and ESBL especially hospital acquired infection. A finding of this study is indicating alarming situation of public health and it should control through interdisciplinary one health approach.
A case report of bloodstream infection by Prototheca zopfii: An emerging opportunistic pathogen
Authors: Tak Heena , Lali Bhumika Chandra , Amber Tabassum
Published: April 2024

This case report describes the presentation, investigation, and diagnosis of algaemia ( algaemia) in an immunocompromised patient with hematological malignancy. A patient of acute lymphoblastic leukemia was admitted with febrile neutropenia after a few weeks of induction chemotherapy. During hospital stay, the patient developed severe body pain, loss of appetite and persistent fever after a week of recovery. Upon thorough investigation, the patient was found to have central line related bloodstream infection with an emerging opportunistic environmental pathogen of genus species , sensitive to Amphotericin B, Fluconazole, Voriconazole, Micafungin and Caspofungin. Liposomal Amphotericin B, an antifungal treatment was prescribed, post-treatment blood cultures were negative.