bluuebunny/crossref_metadata_2025 huggingface dataset:
An Integrated Model of Dissatisfaction Role in Understanding Post-Purchase Behavior in Sustainable Industry
Authors: Zrelli Imen
Published: October 2023

This research proposes to apprehend the debate relating to the risks of tariff modulation in particular at the customers post-purchase behavior in sustainable industry. Each Price modulation generates a different reaction from customers. This reaction can take place on two levels. The first concerns the elasticity of demand with respect to price and the second concerns rather the perception of the service itself. The price elasticity of demand is one of the measures of the effectiveness of marketing actions and helps to understand the state and dynamics of markets. The higher the price, the lower the demand. Moreover, a minority of customers is ready to buy the same service at a higher price. Each price difference translates into a change in demand according to the elasticity. Tariff modulation as a strategic decision must be well studied before its implementation. This is because of its significant impact on the perception of the service, especially as customers link the price to other factors, including quality.  To understand how customers perceive the price and consider bringing together services at different prices satisfying the same needs, we are going to conduct a field survey that will focus on the service sector, we are going to test the impact of dissatisfaction with Price modulation on post-purchase behavior and see how it plays a full mediating role between Price modulation and brand detachment.  We chose the questionnaire survey method for clients, since it allows us to gather a large number of variables and provide operational measures of qualitative variables. This by using psychometric scales accompanied by attitude scales which make it possible to calculate scores for each respondent. In the conclusion, it would be interesting to concentrate the effort on the search for new managerial orientations concerning the application of transparency and relational.
Role of Supply Chain Management in Quality of Healthcare Services
Authors: Chauhan Poonam , Nagappa A.N.
Published: October 2023

Healthcare organizations in Haryana (Kurukshetra) face many supply chain management challenges that can be addressed through effective operational and management decisions. The aim of this paper is to examine the supply chain management of healthcare quality in developing countries, particularly in rural healthcare in Haryana (Kurukshetra), and to consider demographic variables such as gender, age, education level and healthcare experience. Design and Hypothesis Testing Approach Distributed 500 questionnaires to determine the impact of aspects of supply chain management on the quality of health services. 27 of his seven procurement officers and administrative staff in Kurukshetra Haryana. The primary method was to collect data from 73 rural health managers and procurement managers to identify the quality and size of health services. The results of our study show that a combination of timely delivery of health products, specifications, level of health product providers and safety in the rural health sector of Haryana (Kurukshetra) is related to the quality of health services. The scope of this article focuses on employing appropriate human resources and highly trained professionals in supply chain departments to improve the quality of health services in the supply chain. As a practical contribution, this article can help healthcare supply chain managers and organizations do their jobs better or create a competitive advantage by addressing the issues and challenges facing individual healthcare managers, organizations and their partners.
Alignment of CSR Strategies with Business Objectives in IT Sector, Focusing on the Competitive Advantage
Authors: Saeidi Sayedeh parastoo , Saeidi Sayyedeh Parisa , Saeidi Parvaneh
Published: October 2023

While numerous researchers have focused on examining the impact of Corporate Social Responsibility (CSR) on various aspects of business in different industries, there still remains a research gap in conducting comprehensive analyses of CSR strategies in Information Technology (IT) sector. Therefore, this study aims to address this gap by evaluating the effects of CSR on competitive advantage in the IT companies. In order to analyze data, AMOS structural equation modeling (AMOS-SEM) method was applied, and data were collected during February-April 2023 from 143 Iranian IT firms where CSR has not been appropriately dealt within theoretical as well as practical terms. The findings reveal that among the four components of CSR — legal, ethical, economic, and discretionary—, ethical, legal, economic, and discretionary dimensions have the most positive impact on competitive advantage, respectively. Taken together, these findings suggest a significant role for CSR in enhancing the level of competitive advantage in IT companies. In addition to the knowledge contribution, this study holds significant practical implications for IT company managers to strengthen their decision-making processes and develop effective CSR strategies.
Can Aggressive Marketing Cause an Ethical Dilemma?
Authors: Hashem Tareq N.
Published: October 2023

Current aimed to answer the question of whether aggressive marketing (Intensity, Frequency, Intrusiveness, Personalization and Persistence) can be seen as an intruder to the ethical value of marketing tactics and strategies. Theoretical framework: Many organizations are seeking multiple approaches to market their product/services. Come of them do not give much attention to the marketing approach as long as it may comeback with profit and promotion to their products. One of these approaches are now called aggressive marketing which is based on organization taking risks and proactive tactics in order to guarantee its share in the market. Design/Methodology/Approach: Through quantitative methodology and a distribution of a questionnaire on (293) managers and officer within companies registered with the Companies Control Department. The answer to the question is the fact that YES, aggressive marketing can be a source of an ethical dilemma and companies must be careful not to cross ethical or legal boundaries in their marketing efforts, such as making false or misleading claims, using deceptive advertising, or engaging in unfair competition practices. Findings: Results also indicated that in some cases, aggressive of marketing can turn into harassment, with individuals receiving multiple phone calls, emails or direct mail that creates a sense of discomfort, anxiety or fear. Such marketing practices could be seen as abusive, unethical, and illegal. The level of intensity in aggressive marketing should be carefully calibrated to balance the need to generate sales with the need to maintain customer trust and brand reputation over the long term. Research, Practical & Social Implications: The theoretical implications of current study would involve examining the relationship between aggressive marketing tactics and their impact on the ethical framework of businesses, organizations and their stakeholders. On a practical level, the study's findings could have significant implications for the way in which companies approach marketing and promotions. Originality/value: The study could also highlight the importance of establishing clear ethical standards and guidelines for businesses and marketers, in order to prevent negative impact on customers and public perception.
Nutraceuticals Play an Emerging Role in SARS CoV2 and Neurological Dysfunction
Authors: S Sriranjini A , Thapliyal Ashish , Pant Kumud
Published: October 2023

The ApoE4 allele is a well-studied genetic risk factor for Alzheimer's disease, a condition with increasing prevalence and no cure. Precision nutrition, which targets metabolic pathways affected by ApoE4, offers a potential tool for disease prevention. However, long-term human studies on effective nutritional protocols for preventing Alzheimer's in ApoE4 carriers are lacking, partly because the precise mechanisms underlying the increased dementia risk in carriers are not fully understood. Fortunately, recent research has shed light on these mechanisms, opening up opportunities for potential risk reduction through lifestyle and nutrition interventions. In this research paper we discuss about the chawanprash phytocompounds and it is found that Terchebin is the effective phytocompund though docking and simulation methods and thereby indicating the potent Nutraceutical against various Neurological manifestations that is caused due to SARS Cov2 and AD. In this review, we explore recent findings on how ApoE4 impacts various cellular processes, including microglia and other inflammatory pathways.
The Impact of Using Visual Grammar on Iraqi EFL Secondary Students’ Performance
Authors: Sultan Hellah , Sultan Amra I.
Published: October 2023

This study sheds light on the aspect of visual grammar, which it’s teaching in Iraq has not received any attention in educational institutions or within the classroom curricula, so it aims at measuring the impact of using visual grammar on EFL secondary students’ performance.
The Aristotelian Conception of Principle as the Theoretical Foundation for a Healthy Cultural Relativism
Authors: Ibarra Silviano de Jesús Anda
Published: October 2023

to elucidate if the three most accepted modalities of cultural relativism -descriptive, normative, and cognitive- are philosophically valid, and consequently healthy for knowledge development, cultural understandings, and knowledge reliability. Theoretical Framework: the theoretical ideas oscillated among the pure reasoning behind cultural relativism, culture theory, the premises of Husserl’s phenomenology, and the Aristotelian notions of principle and relation, among others. Design / Methodology / Approach: the Aristotelian dialectic, which poses an idea to discussion, analyzes it to discard any contradiction; if contradiction emerges, the data and notions behind the discussed idea are hierarchized to the main principles of knowledge for improvement or correction. Findings: the only valid and healthy modality of cultural relativism is the “descriptive” one because it truly seeks the approach and understanding of alterity/otherness as the cultural relativism reasoning claims. Research, Practical & Social implication: the configuration of normative and epistemological systems based on cultural relativism is contradictory, unhealthy, and dangerous for culture and research conclusions. Originality / Value: this work consists of the attempt to conciliate the foundations of western philosophy with the contemporary philosophical doctrines as an invitation to achieve the ideal of culture: set a proper world for humanity.
The Impact of Cancer on Mental Health
Authors: Ugur Kübra
Published: October 2023

Cancer cases have grown significantly more dangerous as people's life expectancies have increased. In addition, cancer patients may experience serious mental health issues that hinder their recovery. There is a gap in cancer treatment where patients are frequently only treated for their cancer and the effects of cancer on mental health are usually ignored. Several psychiatric care programs are available to patients, but few people are aware of them, and cancer patients are not questioned regarding their attraction to these programs. The aim of the study is to analyze the impact of cancer on anxiety and depression level of cancer patients and to understand which prevention program is found more interesting by cancer patients. Seventy patients participated in this study.  Hospital Anxiety and Depression Scale (HADS) has been used to measure anxiety and depression. According to the results, the average anxiety level was 9.36 ± 4.33, and the average depression level was 10.49 ± 3.50. Based on the program selection, the majority of participants selected "Support Groups" with a rate of 41.40%, and "Educational Programs" with a rate of 31.40%.  In conclusion, the average anxiety level was at the borderline, and the average depression level was abnormal. This study shows that the mental health of cancer patients is neglected, and this issue is not sufficiently addressed. Future studies may focus on how to solve this problem more effectively and how to raise more awareness about the mental health of cancer patients.
Simulation of Wearable Microstrip Patch Antenna by Using Textile Material for Ambient RF Energy Harvesting
Authors: Batal Khadija El , Chakhchaoui Nabil , Eddiai Adil , Mazroui M’hammed
Published: October 2023

Future enhancements in radio frequency (RF) energy harvesting technology will make easy the creation of a network with no need of dedicated transmitters, as a reliable source of wireless energy power. Recently, the development and employment of wearable antennas has increased rapidly for application in the miniaturization of wireless communication devices. The principal feature of wearable antennas is that they are designed as garment elements able to transmit or receive wireless signals. In this context, we propose a design of a wearable textile microstrip patch antenna operating for wireless body area network (WBAN)at the resonance frequency =2.40GHz. The microstrip patch antenna with an edge feeding technique is designed and simulated by using the Keysight Advanced Design System (ADS) software. Textile materials have a low dielectric constant that reduces the surface wave losses and increases the impedance bandwidth of the antenna. The chosen dielectric substrate in this work is the jeans fabric with relative permittivity of 1.70, thickness of 1.00 mm and dissipation factor of 0.025. The antenna performance parameters are obtained from ADS Momentum. Simulation results show that antenna has the gain of 3.22 dBi and directivity of 8.10 dBi, showing that the wearable textile microstrip antenna has a good performance.
Adapting Blockchain for Secure and Efficient Identity Management in Oman's e-Government
Authors: AlBadi Asma Hamed salem , AlShibli Aisha Salim Rashid , AlSaqri Dhiya Hamed Ali , AlSariri Arwa Khalfan
Published: October 2023

This research paper examines the potential application of blockchain technology in e-government identity management, with a specific focus on the case of Oman. Traditional centralized identity systems in e-government face various challenges, such as security vulnerabilities and limited compatibility among government agencies. By utilizing the decentralized and unalterable characteristics of blockchain, Oman can enhance the security, privacy, efficiency, and transparency of identity management in e-government. The advantages include improved security and privacy, streamlined processes, data sharing and interoperability, transparency, cost reduction, and empowerment of citizens. The paper presents examples of blockchain-based identity management systems implemented in different sectors and countries, along with research studies in the field. Additionally, a survey was conducted to assess awareness and willingness to adopt blockchain-based identity management in Oman's e-government. The findings emphasize the importance of considering technical requirements, legal frameworks, interoperability standards, and user acceptance for successful implementation. Overall, blockchain technology offers promising solutions to strengthen identity management in e-government and establish a trustworthy digital environment for citizens and businesses.
The Simulation Model of Dengue Transmission by Gender of Human in Thailand
Authors: Pongsumpun Puntipa , Pongsumpun Puntani
Published: October 2023

Dengue disease can be transmitted to human by the biting of infected Aedes aegypti mosquitoes. This disease has 4 serotypes such as DEN-1, DEN-2, DEN-3 and DEN-4. The symptoms of this disease are high fever, headache, body aches, nausea and rash. This paper describes the spread of this disease by formulating the dynamical model between human and mosquito populations. The human are separating into man and woman populations. The standard dynamical modelling method is used to analyze our dynamical model. The numerical solutions are presented. The basic reproduction value of the disease is found. The way for reducing the transmission of this disease is introduced.
Adjusting control charts for inaccurate measurements
Authors: Etga Ran , Freund Sarit
Published: October 2023

The concept of statistics-based control is nearly a century old. The basic assumption is that the measurement is precise and therefore all calculation based on these data is also precise. Typically, this assumption is not far from reality and thus does not affect the proposed control limits. However, in some cases the rounding-off of measurements may lead to erroneous decisions. This study examines the effects of rounding-off on the average (X ?) control lines and suggests a simple method way to design new control lines, based on the conventional average run length (ARL).
Different Methods of Authentication for Mobile Banking
Authors: Nosrati Leili , Nosratri Laleh
Published: October 2023

Online banking authentication has been recognized as a key factor in the security of online banking. nowadays, different methods have been developed for online banking validation which cause problems from hacker attacks and Internet theft. Our research showed that biometrics is appropriate options for dealing with these issues. In this article, different authentication protocols for online banking have been compered.
Discrete Wavelet Transform and Ensemble Tree Algorithms for Air Pollutant Modeling: A Case Study
Authors: Gocheva-Ilieva Snezhana Georgieva , Ivanov Atanas Valev , Stoimenova-Minova Maya Plamenova , Koleva-Pavlova Stoyanka Krasimirova Koleva-Pavlova
Published: October 2023

Air pollution is one of the greatest environmental problems of our time on a global and local scale. Elevated and even low but constant levels of harmful emissions in the air in urbanized areas pose serious risks to the health of the population. This paper develops a new approach for statistical modeling of time series of air pollutants, depending on meteorological factors. A new framework based on discrete wavelet transform (DWT) is proposed for decomposing pollutant's time series as a sum of components that represent trend, seasonality, and other specific characteristics. A key element in the applied DWT is an adaptive scheme for selecting the threshold value to control the reverse DWT's accuracy for achieving better prediction of the time series values. The resulting components are modeled with cutting-edge predictive ensemble tree algorithms, including bagging, boosting, and stacking techniques. This approach is tested with real data measured with a mobile automated station in the Plovdiv region, Bulgaria. All models are evaluated, analyzed, and cross-validated. The models are applied for short-term pollution forecasts.
The Phenomenology of Tactile Perception for Design
Authors: Sinico Michele
Published: October 2023

For design, tactile perception is a crucial dimension of the user experience. Design disciplines can find an essential body of knowledge in the tradition of the psychology of perception. This article first introduces the physiological aspects, starting from receptor differences and leading to the tactile representation in the brain. Consistent with the phenomenological perspective, it is argued, however, that the reductionist approach provides an understanding of physiological mediation, useful for knowing the functioning of the organism, but not sufficient to make the user's perceptual-tactile experience immediate. The perceptual-tactile experience extends to the dimension of the self and demonstrates that the bodily self extends beyond the boundaries of the physical body. For the designer, therefore, scientific knowledge of the tactile experience derived from experimental phenomenology, developed from Gestalt psychology, is a priority.
Aerodynamic Performance Assessment of an Airfoil at Reynolds Number 10000: A Computational Approach
Authors: Teja J. Navya , Bodavula Aslesha , Dussa Govardhan
Published: October 2023

Effects of a low Reynolds number flow on an airfoil with cavities of a specified shape are analyzed computationally to assess the aerodynamic performance by observing the coefficients of lift and drag with increasing angles of attacks. The Reynolds number considered for the simulation is 1×104 operating at atmospheric conditions at sea level. Indentations with a definite shape (right-angled triangle) are utilized to find the vortex effects of air in the cavity on the shear layer separation on airfoil surface to retain the flow even at higher angles of attack. The simulation is run in ANSYS Fluent to study the increase in the aerodynamic performance, research findings include an increase in coefficient of lift values by approximately, 111.86% of cavity with depth 0.05C indented at 70% of the chord length at 6° angle of attack, 68.13% of cavity with depth 0.05C indented at 50% of chord length at 6° angle of attack, 23.93% of cavity with depth 0.025C indented at 70% of chord length at 6° angle of attack, 3.96% of cavity of depth 0.025C at 6° angle of attack, 9.59% of cavity of depth 0.05C at 18° angle of attack.
Comparative Analysis of ISO27001 and NIST CSF
Authors: Alghamdi Ahmed
Published: October 2023

Recent developments in Information and Communication Technology (ICT) have had a significant impact on commercial organizations in achieving their goals and objectives. However, the introduction of ICT introduced new cyber risks and threats as well. To mitigate cyber threats, various cybersecurity frameworks and standards are available e.g., ISO/IEC27001 and NIST Cybersecurity Framework (CSF). These frameworks can be used to measure/ audit the maturity level of an organization’s cybersecurity status. In this study, we have compared the ISO 27001 and NIST CSF and map these frameworks with each other.
Biomechanical Properties and Mechanotransduction of Skeletal Muscles as The Basis for The Use of Myofascial Osteopathic Techniques
Authors: Novoseltsev S. V. , Reshetnikov A. G. , Vyunov V. D. , Suleymanov T. R. , Nefedova A. M. , Solomatov P. G. , Taranenko S. I. , Kryazheva A. M. , Moskvicheva . V.
Published: October 2023

Skeletal muscles are an important link in human biomechanics. Every movement depends on muscle strength and is important for maintaining health and quality of life. Mechanical loads on the human body directly depend on the state of muscle tissue, so it is necessary to understand the cellular composition and regulation of the tissue responsible for the processes of mechanotransduction . This, in turn, makes it possible to develop methods of effective manual intervention in complex rehabilitation for patients with dysfunctions of the musculoskeletal system. This review describes the molecular basis of mechanotransduction in muscle tissue.
An Empirical Study on Sustainable Marketing Through Social and Environmentally Responsible Marketing Activities in The Restaurants In UAE
Authors: Byloppilly Rameshwaran
Published: October 2023

This paper investigates into the measures taken by the fast-food restaurants in the UAE to promote sustainable marketing through socially and environmentally responsible marketing activities and analyse the extent to which these fast-food restaurants have adopted sustainable marketing principles. The world population is facing problems like environmental pollution, increased carbon footprint, and unethical business practices. One of the causes of this pathetic state of affairs are the mushrooming fast-food restaurants which have contributed largely to the environmental footprint due to its wasteful packaging, inefficient waste disposal, and inefficient use of energy in its outlets. It was observed that the majority of the international fast-food restaurants were implementing sustainable marketing principles to a great extent. Though a few small local fast-food restaurants were aware of the sustainable marketing principles, however, they were finding it difficult to implement them in practice as these local restaurants were small business firms with low financial returns.
Nutriphytochemical Profiling and Changes in Cardiovascular Risk Index in Malarial Infected Mice Treated with Ethanol Root Extract of Phyllanthus Amarus
Authors: Opajobi Adefunke O. , Uzuegbu Ugochukwu E. , Olawale Ajala Michael , Toloyai Pere-Ebi Y. , Elu Chinwendu O. , Igwenyi Ikechukwu , Onyesom Innocent
Published: October 2023

Purpose: The use of medicinal plants in malarial treatment has become popular in Nigeria, an endemic country, due to failing chemotherapy and high cost of antimalarial drugs. One of such commonly used herbs is Phyllanthus amarus. The antimalarial activity of P. amarus has been consistently reported, giving credence to its traditional use. Nevertheless, effects of such treatment on reducing cardiovascular risk indices is yet to be fully documented. This is imperative since certain metabolic complications like increased plasma lipids have been associated with considerable risks of fatty liver and cardiovascular diseaes in severe cases of malaria in humans. Methods: In this present study, therefore, the antiplasmodial action of the ethanol root extract of P. amarus and its ED50 dose were determined and associated cardiovascular risk indices were evaluated in BALB/c malarial infected mice, having ascertained the nutritive quality and phytochemicals of plant root. Results: Results showed that P. amarus root is abundant in alkaloid phytochemical and the roots extracts demonstrated significant antiplasmodial activity in a dose-dependent trend with optimal ED50 and maximal potency in reducing cardiovascular risk indices (Atherogenic index of plasma, AIP and heart disease risk, HDR) and fatty liver, which compared well with the values obtained from the uninfected control mice. Conclusion: The roots of P. amarus possess a wide array of nutrients and phytochemicals, with significant antimalarial activity. The roots also reduced the risks of cardiovascular diseases associated with severe malaria, in experimental mice.
Effectiveness Of Education Regarding Stunting Prevention to Cadres: Systematic Literature Review
Authors: Elba Fardila , Hassan Hafizah Che , Umar Nur Syazana
Published: October 2023

Stunting, a disease characterized by prolonged nutritional deficiency during the initial 1,000 days of a newborn's life, continues to be a significant health concern in Indonesia, holding the second highest global prevalence. Ineffective parenting practices, insufficient prenatal care, challenges getting to nutrients and clean water, and infectious illnesses are some of the factors that contribute to childhood stunting. The provision of education to cadres on the prevention of stunting is one of the aspects of stunting prevention that plays a significant role in the process of overcoming the variables which lead to stunting from their underlying causes. Through the transmission of health information, the training that is offered to cadres has the potential to promote public health. This research wants to see how effective stunting education is in increasing cadres' knowledge about stunting prevention. In this study, a systematic literature review was combined with a search for systematic studies using the PRISMA technique, and the search was conducted on two national journal portals. The primary discussion of the study was based on six papers, all of which were investigated with a cross-sectional design that included stunting prevention instruction for cadres. These studies were chosen for the research project. Education with audiovisual media and lecture and discussion techniques has a 70% efficacy rate in expanding cadre knowledge. This is the way with the highest effectiveness rate.
Empowering Sustainability: The Promise of Energy Harvesting from Wheel Motion (Experiment and simulation)
Authors: Alwafaie Mohammed Alaa , Kovacs Bela
Published: October 2023

The evident rise in the demand for durable and environmentally friendly power solutions in the future has spurred the advancement of inventive energy harvesting architectures, specifically emphasizing renewable sources such as wind and solar power. This study aims to make a valuable contribution to the field of energy harvesting by introducing an original concept: the utilization of energy generated from wheel motion. The proposed method involves strategically positioning magnets and copper coils inside the hubcap's spoke. As the wheel rotates, the magnets' movement induces a winding action within the coils. This dynamic interaction, in accordance with Faraday's Law, generates an electric current within the coil. To assess the effectiveness of this approach, a meticulously designed experimental setup was implemented, measuring the output voltage of the electromagnetics. These measurements provide significant insights into the energy harvesting potential of this method. Furthermore, to ensure the reliability and accuracy of the findings, a numerical simulation was conducted, enabling a comprehensive analysis and validation of the experimental results. By exploring the concept of wheel motion energy harvesting, this research strives to contribute to the development of sustainable and efficient power generation solutions. The integration of electromagnetic principles into this innovative approach highlights the viability of utilizing wheel motion as a practical energy source. These findings pave the way for further advancements in energy harvesting technologies, fostering a more sustainable and environmentally friendly future.
Congenital Neck Masses
Authors: Ryu Jane , Igawa Teryn , Mohole Jyodi , Coward Melissa
Published: October 2023

There are many possible causes of congenital neck masses, with the most common ones being thyroglossal duct cysts, branchial cleft anomalies, and vascular malformations. Most congenital neck masses are asymptomatic in the neonatal period, but depending on the location and the size, they can cause airway obstruction and serious complications at birth. Proper diagnosis is important for optimal treatment planning, and if the airway is compromised, multidisciplinary teamwork is critical for proper airway management. This review summarizes the clinical features, etiology, diagnosis, management, and prognosis of different types of congenital neck masses.
Neonatal Surgical Procedures in the Intensive Care Unit versus the Operating Room
Authors: Brown Lindsay , Ayad Ihab , Iravani Marc
Published: October 2023

With advancements in neonatal care, the survival rates of preterm infants have increased, leading to a higher incidence of comorbidities and need for surgical interventions. Neonatologists, pediatric anesthesiologists, and pediatric surgeons are thus increasingly confronted with the decision of whether to perform surgical procedures on critically ill neonates and preterm infants in the operating room (OR) or the NICU. Although certain bedside procedures have been commonly described in the literature, a paucity of research exists regarding ideal patient selection and anesthetic management. In this review, we will examine the decision-making process for providing anesthetic care in the OR versus the NICU as well as investigate appropriate sedation agents for procedures occurring in the NICU. Ultimately, the location of the surgery should be determined by the circumstances of each patient and involve collaboration of the entire perioperative team.
A pajzsmirigy primer laphámcarcinomája.
Authors: Lévay Bernadett , Kiss Alexandra , Oberna Ferenc , Slezák András , Tóth Erika
Published: October 2023

A pajzsmirigyből kiinduló primer laphámcarcinoma az endokrin tumorokra vonatkozó
WHO-klasszifikáció legújabb, 2023-ban megjelent 5. kiadása alapján az
anaplasticus pajzsmirigy-carcinomák csoportjába tartozik. Igen ritka
előfordulású betegség, kedvezőtlen prognózis és rövid túlélési idő jellemzi.
Tanulmányunk célja felhívni a figyelmet ennek a ritka kórképnek a műtéti,
valamint terápiás nehézségeire. A 68 éves nőbeteget nehézlégzés és gyorsan
növekvő, jobb oldali nyaki terime miatt utalták intézetünk Fej-Nyak Sebészeti
Ambulanciájára. A fizikális vizsgálat során a nyak jobb oldalán fixált képletet
és a jobb oldali gégefél paresisét észleltük. Az aspirációs citológiai vizsgálat
laphámcarcinomát véleményezett a pajzsmirigyben, a képalkotó vizsgálatok
(18FDG-PET/CT) kizárták az egyéb fej-nyaki régióból történő
kiindulás lehetőségét. Műtétet végeztünk, melynek során a teljes pajzsmirigy
eltávolítását kíséreltük meg. A szövettani vizsgálat megerősítette a korábbi
citológiai vizsgálat során kórismézett, pajzsmirigy kiindulású laphámcarcinomát.
A megkezdett palliatív sugárterápia ellenére a beteg elhunyt. A pajzsmirigy
primer laphámcarcinomájának felismerése és kezelése komoly kihívást jelent a
sebésznek, valamint a kezelést végző team tagjainak. A túlélés tekintetében a
limitált sugár-, valamint kemoterápiás válaszkészség miatt kiemelt szereppel bír
a komplett sebészi eltávolítás, valamint az esetlegesen jelen lévő, terápiásan
célozható molekuláris patológiai eltérések azonosítása. Orv Hetil. 2023;
164(39): 1556–1559.
Gyermekkori neuroblastoma kezelésében alkalmazott 131-I-meta-jodo-benzil-guanidin terápia.
Authors: Gilitsch Annamária , Vojcek Ágnes , Mezősi Emese , Bán Zsuzsanna , Csernus Katalin , Ottóffy Gábor
Published: October 2023

A gyermekkori malignus betegségek egytizedét képviselő neuroblastoma klinikailag
és prognosztikailag is rendkívül heterogén betegség. A rossz prognózisú
esetekben a túlélést az utóbbi időszakban a gyorsan fejlődő multimodális terápia
jelentősen javította. Négy éves betegünk kivizsgálását bitemporalis duzzanat
miatt kezdtük meg, melynek hátterében IV. stádiumú neuroblastoma igazolódott
(csontvelői és multiplex csontáttétek). A kezelésre kezdetben jól reagáló tumor
posztkonszolidációs terápiája során azonban recidíva jelentkezett. A nagy
kockázatú, rossz prognózisú betegség ’salvage’ terápiájának részeként –
gyermekkori neuroblastoma esetében hazánkban először –
131-I-meta-jodo-benzil-guanidin-kezelést alkalmaztunk. A neuroendokrin szövetek
sejtjeinek noradrenalin transzportere képes a katecholaminanalóg
meta-jodo-benzil-guanidin felvételére. Ez az alapja a molekula képalkotásban
(123-I-meta-jodo-benzil-guanidin) és célzott terápiában
(131-I-meta-jodo-benzil-guanidin) történő felhasználásának, többek között
neuroblastoma esetében is. A 131-I-meta-jodo-benzil-guanidin-kezelés speciális
személyi és tárgyi feltételekhez van kötve, s különösen igaz ez gyermekkori
alkalmazására. Alapos szervezés mellett a radioizotóp-terápiában jártas
nukleáris medicina szakorvosok és kooperáló klinikusok (gyermekonkológusok,
szükség esetén felnőttbelgyógyászok) szoros együttműködését igényli. A külföldön
már rutinszerűen alkalmazott meta-jodo-benzil-guanidin-terápia napjainkig a
recidív neuroblastoma ’salvage’ terápiájának részeként jött szóba, azonban a
jelenleg még zajló klinikai vizsgálatok alapján a közeljövőben az első vonalbeli
kezelés részévé válhat. Az indikációs kör szélesedése miatt szükségszerű, hogy
hazánkban is egyre több gyermek számára váljon elérhetővé a kezelés. Orv Hetil.
2023; 164(39): 1550–1555.
Frequency of Rotavirus and Adenovirus in Children with Diarrhea
Authors: DURAN Hülya , YILMAZ YÜCEL Fadime
Published: October 2023

ABSTRACT
Aim: The aim of this study is retrospective evaluation of the frequency of rotavirus and adenovirus in stool, and their distribution according to gender, age and seasons in children with diarrhea admitted at outpatients or hospitalized in our hospital.
Material and Methods: Stool samples of patients aged between 0-18 years received at the Medical Microbiology Laboratory between 2021–2022 were evaluated for rotavirus–adenovirus. Rotavirus and adenovirus antigens were determined qualitatively by immunochromatographic cassette test method. Chi-square test was used in the statistical analysis.
Results: A total of 1148 stool samples of pediatric patients were received by our laboratory during these two years for rotavirus and adenovirus antigen test. Of 1148 patients, 8.6% were positive for rotavirus, 5.1% for adenovirus, and 0.6% for both rotavirus and adenovirus antigens. Rotavirus and adenovirus was positive in 7.2% and 5.6% of males, respectively, and 10.6% and 4.5% of females, and there were no statistically significant differences. Rotavirus was most frequently found in the age group 3-5 years (11.6%) and adenovirus was most frequently found in the age group 6-9 years (8.4%), with no significant difference. Rotavirus was most frequently detected in spring (12.9%) while adenovirus was found most frequently in winter (8.1%), without significant differences. Antigen positivity was 4.1% and 4.9% in outpatients for rotavirus and adenovirus, respectively, and 15.1% and 5.5% in hospitalized patients. Rotavirus positivity was significantly higher in hospitalized patients than outpatients, and adenovirus positivity did not show a significant difference.
Conclusion: We found that rotavirus and adenovirus were significant agents causing diarrhea in children, especially those younger than 5 years old, and that its frequency increased in winter and spring, and as rotavirus is a cause of hospitalization, implementation of rotavirus vaccine into routine vaccination programs seem to be beneficial for patients.
Clinical Observation in Premature Babies with Feeding Intolerance
Authors: ÖZCAN Beyza , BÜYÜKEREN Melek , KENAR Aytaç , KEÇECİ Ramazan
Published: October 2023

Objective: Feeding intolerance (FI) is a digestive disorder that manifests itself with gastric residue, abdominal distension, and vomiting, especially in preterm infants, and often causes a prolongation of the transition to full enteral feeding. Nutrition strategy is a significant clinical challenge for neonatologists. It is tried to treat feeding intolerance with methods such as minimal enteral nutrition and slow increase in sustenance, probiotic use, prevention/treatment of NEC and sepsis, and use of specially formulated foods, but these methods are only partially effective.

Methods: Babies under 32 weeks and 1500 g hospitalized in Konya City Hospital between August 2020 and January 2022 were evaluated retrospectively. Babies with and without feeding intolerance were divided into two groups, and their demographic and clinical conditions were examined. The treatment modalities of the group with feeding intolerance were evaluated.

Results: Of the 86 patients in the study, 36 were included in the FI group, and 50 were in the healthy control group. Late neonatal sepsis and duration of parenteral nutrition were found to be statistically significantly higher in the group with feeding intolerance compared to the control group (p
Evaluation of restless legs syndrome in children with allergic rhinitis
Authors: ALTAS Ugur , BİBİNOĞLU AMİROV Ceren , ALTAŞ Zeynep Meva , TUNCE Eray , KUTLUBAY Büşra , ÖZKARS Mehmet Yaşar
Published: October 2023

Aim: It was aimed to evaluate the frequency of restless legs syndrome (RLS) in children with a diagnosis of allergic rhinitis (AR).

Material and Method: The study is case-control type. Age, gender, height, weight, Body Mass Index (BMI), allergic rhinitis symptom score, allergic rhinitis severity, allergy tests, total IgE, eosinophil values of the case group were examined. Gender, age, height, weight and BMI were also calculated in the control group. Patients in both groups were questioned using the International Restless Legs Syndrome Study Group's (IRLSSG) questionnaire containing the latest diagnostic criteria and severity scoring revised for the pediatric age group. Neurological examination, questionnaire and RLS severity scoring results of the patients were performed by a pediatric neurologist.

Results: In the study, the data of a total of 230 children, 115 AR cases and 115 control groups, were evaluated. The frequency of restless legs syndrome in children with allergic rhinitis was significantly higher than in the control group (15.7% and 5.2%, respectively; p=0.010). The clinical severity of RLS patients was mostly moderate in both the case and control groups [44.4% (n=8) and 50% (n=3), respectively].

Conclusion: According to the results of our study; restless legs syndrome was observed more frequently in patients with allergic rhinitis compared to the control group.
Evaluation of Vitamin B12, Folic Acid, Ferritin and Vitamin D Levels in Obsessive Compulsive Disorder
Authors: İMRE Okan , KOCABAŞ Rahim
Published: October 2023

Aims: Obsessive compulsive disorder (OCD) is a heterogeneous disorder characterized by obsessions and compulsions. Despite the studies, etiopathogenesis is not fully understood. Pharmacological and psychosocial interventions in OCD may be insufficient due to limited knowledge of etiopathogenesis. Therefore, it is important to find inexpensive and easily determined biochemical parameters related to etiopathogenesis. In this study, the relationship between OCD and vitamin B12 (VitB12), folic acid (FA), vitamin D (VitD) and ferritin was investigated.

Material and Method: 50 patients with OCD (12 female, 38 male) and 50 healthy controls (HC) (13 female, 37 male) were included in this retrospective study. Serum VitB12, FA, ferritin and 25-OH VitD levels of both groups were compared.

Results: VitB12 (p
Bibliometric analysis of scientific literature on Acanthamoeba keratitis
Authors: EVLİCE Oğuz , YÜCEKUL Burcu
Published: October 2023

İntroduction: Our research aimed to assess Acanthamoeba keratitis research trends and compare contributions from various nations, institutions, journals, and authors.

Methodology: A bibliometric design was used. We used the Web of Science database to extract all Acanthamoeba keratitis articles from 1970 to 2021. To collect publishing data, analyze publication trends, and visualize relevant data, Microsoft Excel and VOSviewer were used.

Results: 171 (31.784 %) of them were published as open Access. 92.751% of them were published in Science Citation Index Expanded indexed journals. The mean number of citations was 13733, with a median of 25.53, and the H index was 63. 77.32 % of the articles were published since 2000. University of Texas in the United States had the highest number of publications (78, 14.499%), followed by the University of London in the UK (63,11.71%). The United States (USA) ranked first in the number of publications (151, 28.067%), followed by the United Kingdom (49, 9.108%) and Germany (31, 5.762%). Publications from the USA were cited 6,344 times (42.01/median per publication), while publications from the UK were cited 2,949 times (60.18/median per publication). Acanthamoeba keratitis research has increased significantly in the last 15 years.

Conclusions: With the use of information visualization analysis, we were able to gain a wide understanding of the state of affairs, recognize trends, and identify hotspots. It is a more effective way to learn the literature and could give future researchers summarized data
Survival Outcomes and Factors Affecting Prognosis in Patients with Head and Neck Region Mucoepidermoid Carcinoma Treated with Adjuvant Radiotherapy
Authors: DUZOVA Mursel , AKIN Mustafa
Published: October 2023

Aim: This study aims to ascertain the clinical and pathological factors linked to the outcomes of patients subjected to surgical intervention and postoperative radiotherapy for mucoepidermoid carcinoma (MEC) originating from both major and minor salivary glands in the head and neck region.
Material and Method: In this retrospective review, medical records of 42 patients who underwent surgery and subsequent radiotherapy for localized MEC in the major and minor salivary glands of the head and neck were analyzed to identify clinicopathological determinants of overall survival. Secondary endpoints encompassed local-regional control, distant metastasis-free survival, and disease-free survival.
Results: The median age of the patient cohort was 56 years, comprising 52.4% males and 47.6% females. The median follow-up period spanned 36 months, with a range of 6 to 88 months. All patients underwent curative surgery, followed by adjuvant radiotherapy. The 2-year and 5-year rates for overall survival (OS), local-regional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and disease-free survival (DFS) were 92% and 72.6%, 92.2% and 85.6%, 84.8% and 73%, 82% and 67.3%, respectively. Notably, only histologic grade emerged as a statistically significant prognostic factor, influencing both OS (p=0.019), DMFS (p=0.014), and DFS (p=0.044).
Conclusion: The histologic grade of the tumor is the foremost determinant impacting the outcomes of MEC cases. Adjuvant radiotherapy is recommended for high-grade tumors, while its application for low-grade and intermediate-grade tumors should be individualized based on the anticipated risk of recurrence. This underscores the significance of tailoring treatment approaches according to histologic characteristics.
Knowledge Level of High School Students about Crimean Congo Hemorrhagic Fever
Authors: AYDIN Emsal
Published: October 2023

Abstract

Introduction: The aim of this study is to determine the knowledge level of high school students about CCHF disease.

Materials and Methods: The population of the study, which was planned in descriptive type, consisted of 530 students in the first, second, third and fourth grades of high school, and 54.9% (n:291) of the students were reached. Verbal consent was obtained from the students and they were asked to fill out the questionnaire consisting of 15 questions. Data were calculated using mean, frequency and percentage in SPSS database.

Results: In the study, although the students knew that the transmission was by tick contact, they did not have enough information about how the transmission was, what to do in case of tick contact and the symptoms of the disease

Conclusion:. It is necessary to increase the knowledge level of students in order to prevent contagion. In order to increase the level of knowledge, the deficiencies of the students should be determined and the necessary training should be planned.
The Prognostic Value of Systemic Immune Inflammation Index in Children with Carbon Monoxide Poisoning
Authors: Özdemir Kaçer Emine
Published: October 2023

Backgrounds: Carbon monoxide (CO) is an odorless and colorless gas that forms when organic materials burn incompletely. Children are more susceptible to CO poisoning than adults because their respiratory and immune systems are still developing. The systemic immune inflammation index (SII) is a marker that reflects the balance between inflammation and immunity.
Aims: In this study, we investigate the relationship between CO poisoning in children and SII.
Materials and Methods: We conducted a retrospective observational study involving pediatric patients (age
Investigation of Thought Control and Obsessive Beliefs in Generalised Anxiety Disorder and Panic Disorder
Authors: PUŞUROĞLU Meltem
Published: October 2023

Aims: Obsessive beliefs and thought control are often thought to be associated with Obsessive Compulsive Disorder. However, the relationship with anxiety disorders has recently been investigated in the literature. In this study, Obsessive Beliefs and Thought Control levels in patients diagnosed with Generalised Anxiety Disorder and Panic Disorder were investigated. It is aimed to contribute to the literature on the cognitive aspects of anxiety disorders.

Material and Method: According to DSM 5 diagnostic criteria, 71 patients diagnosed with Generalised Anxiety Disorder, 63 patients diagnosed with Panic Disorder and 63 healthy controls were included in the study. The participants were applied the Thought Control Questionnaire and Obsessive Beliefs Questionnaire. In addition, Beck Anxiety Scale was applied to patients diagnosed with Generalised Anxiety Disorder and Panic Agoraphobia Scale was applied to patients diagnosed with Panic Disorder.

Results: A statistically significant difference was found between the groups in Distraction (F=11.383; p=