bluuebunny/crossref_metadata_2025 huggingface dataset:
Animalistic dehumanisation as a social influence strategy
Authors: Quiamzade Alain , Lalot Fanny
Published: January 2023

The phenomenon of animalistic dehumanisation has been extensively studied in social psychology, but mostly as an intergroup relations tool used to justify the mistreatment of an outgroup. Surprisingly, however, dehumanisation has not been approached as an influence strategy to convince the ingroup to mistreat an outgroup. In the present article, we investigate these possible influence effects. We propose that a message depicting an outgroup in negative animalised terms would lead to lasting unfavourable outgroup attitudes because the animal essence conveyed through the message would immunise ingroup members against subsequent counterinfluence attempts. In one experimental study we compared the effect of three influence messages depicting a despised outgroup (Roma beggars) in negative animalised vs. negative humanised vs. positive humanised terms, followed by a counterpropaganda message advocating for Roma beggars’ rights. Results show that the animalisation message leads to a lasting animalised perception of the outgroup (eliciting disgust and repugnancy) that resists exposure to the counterpropaganda positive message. In contrast, the negative humanisation message provokes a brief negative perception of the group (pre-counterpropaganda) that disappears after exposure to the counterpropaganda. The animalisation message also leads to more negative attitudes and discriminatory behavioural intentions towards Roma beggars expressed after the counterpropaganda message (i.e., discrimination in the workplace, hiring intentions, and social proximity), whilst the negative humanisation message does not, showing no difference with the positive humanisation message. These results suggest that animalistic dehumanisation indeed acts as an influence strategy, immunising targets against subsequent counterpropaganda attempts. We discuss implications in the light of essentialisation, forms of dehumanisation and group status, and current non-discriminatory norms.
Desynchronized white matter function and structure in drug-naive first-episode major depressive disorder patients
Authors: Guo Qinger , Duan Jingfeng , Cai Shuyang , Zhang Jiaxi , Chen Tao , Yang Hong
Published: January 2023

Background

Major depressive disorder (MDD) is a highly prevalent mental disease. Using magnetic resonance imaging (MRI), although numerous studies have revealed the alterations in structure and function of grey matter (GM), few studies focused on the synchronization of white matter (WM) structure and function in MDD. The aim of this study was to investigate whether functional and structural abnormalities of WM play an essential role in the neurobiological mechanisms of MDD.

Methods

Gradient-echo imaging sequences at 3.0T were used to gather resting state functional MRI (rsfMRI) data, which were performed on 33 drug-naive first-episode MDD patients and 34 healthy controls (HCs). After data preprocessed, amplitude of low frequency fluctuation (ALFF) of WM was calculated. ALFF values in different frequency bands were analyzed, including typical (0.01–0.15 Hz) band, slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz) bands. In addition, the fractional anisotropy (FA) values in WM in 23 patients and 26 HCs were examined using tract-based spatial statistics (TBSS) and tractography based on diffusion tensor imaging (DTI). Pearson correlation analysis was applied to analyze the relationships between ALFF values and Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA).

Results

Compared with the HCs, MDD patients showed decreased ALFF values in posterior thalamic radiation (PTR) and superior longitudinal fasciculus (SLF) in slow-5 frequency band, no significant differences of ALFF values were found in typical and slow-4 frequency bands. In addition, there were no significant differences in FA values with TBSS analysis as well as the number of fibers in PTR and SLF with tractography analysis between two groups. Further correlation analysis showed that the ALFF value in SLF was negatively correlated with HAMA-2 score (r = −0.548, pFDR = 0.037) in patients.

Conclusion

Our results indicated that WM dysfunction may be associated with the pathophysiological mechanism of depression. Our study also suggested that the functional damage of the WM may precedes the structural damage in first-episode MDD patients. Furthermore, for mental disorders, slow-5 frequency band may be a more sensitive functional indicator for early detection of abnormal spontaneous brain activity in WM.
Impacts of industrial agglomeration on industrial pollutant emissions: Evidence found in the Lanzhou–Xining urban agglomeration in western China
Authors: Jia Zhuo , Chen Qi , Na Heya , Yang Yongchun , Zhao Jinyao
Published: January 2023

Industrial agglomeration does not only promote economic and social prosperity of urban agglomeration, but also increases industrial pollution, which poses a health risk to the general public. The Lanzhou–Xining urban agglomeration in western China is characterized by industrial agglomeration and serious industrial pollution. Based on the county panel data of the Lanzhou–Xining urban agglomeration in western China from 2010 to 2018, a research of the impacts of industrial agglomeration on industrial pollutant emissions was conducted by using spatial analysis technology and spatial econometric analysis. The results indicate that industrial agglomeration is an important factor leading to an increase in industrial pollutant emissions. In addition, population density, economic level, and industrial structure are also important factors that lead to the increase in industrial pollutant emissions. However, technological level has led to the reduction in industrial pollutant emissions. Furthermore, industrial pollutant emissions are not only affected by the industrial agglomeration, population density, economic level, industrial structure, and technological level of the county but also by those same factors in the surrounding counties, owing to the spatial spillover effect. Joint development of green industries and control of industrial pollutant emissions is an inevitable result for the Lanzhou–Xining urban agglomeration in western China.
Externalities, scarcity, and abundance
Authors: Frischmann Brett M. , Ramello Giovanni B.
Published: January 2023

Introduction

Do externalities work and matter differently in a world of scarcity vs. a world of abundance? In this article, we critically examine the economic phenomena of externalities. The concept of externality, an important idea in economics and law, is useful in exploring the complex and dynamic relationships between resource supply and human flourishing within various sociotechnical systems.

Methods

First, we define the basic concept and explain why it is fundamental to economic analysis of complex social environments Second, we briefly survey the intellectual history of externalities with the goal of tying together a few different strands of economic theory and providing a roadmap for a general theory of externalities. This discussion highlights a latent conflict between those who pursue and those who resist perfectibility (optimization) of social systems by internalizing externalities. Third, we compare externalities in worlds of scarcity and abundance.

Results

This article develops the theoretical framework, including a brief intellectual history and notes toward the development of a general theory of externalities. As a conceptual tool, externalities enable one to identify and examine social interdependencies and to map their causes and consequences. Externalities provide evidence of social demand for governance institutions. This descriptive utility can and should inform normative analysis, the design of governance institutions, and comparative institutional analysis. We also raise a series of (mostly empirical) questions that should frame comparative institutional analysis and evaluation of different externalities in the digital networked world.

Discussion

We focus on the scarcity and abundance of knowledge resources and the (technological) means for participating in the production, dissemination, and modification of such resources. In the real, necessarily imperfect world where abundance and scarcity vary across resources, people, and contexts, externalities persist, indicate social demand for governance, and inform comparative analysis and design of governance institutions.

JEL classification

D62, B52, D02.
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignant tumors in children: Initial experience in a single institution
Authors: Zhu Zhiyun , Chang Xiaofeng , Wang Jiarong , Yang Shen , Qin Hong , Yang Wei , Cheng Haiyan , Meng Deguang , Wang Huanmin
Published: January 2023

Background

Peritoneal malignant tumors in children are rare but commonly associated with disease progression and poor outcome. The successful treatment experience of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in adult peritoneal carcinoma has been applied to pediatric peritoneal malignancy in recent years. However, patients with desmoplastic small round cell tumor (DSRCT) accounted for the majority of patients treated with CRS and HIPEC in previous studies. The role of CRS and HIPEC remains controversial due to the rarity of the disease and the limited sample size of studies. Additionally, the cases using CRS and HIPEC except DSRCT were mainly small case reports with unclear outcomes. We present our experience in the treatment of pediatric peritoneal malignancies using CRS and HIPEC, with more emphasis on the safety, feasibility, and short-term outcome.

Methods

A retrospective query from December 2019 to February 2022 identified 19 children with peritoneal malignancies who underwent CRS and HIPEC in our institution. Clinical characteristics, therapies, and outcomes were summarized and analyzed.

Results

The median age of the patients was 6.4 years (range, 0.7–13.9 years). The histologic types included rhabdomyosarcoma (7), Wilms tumor (2), clear cell sarcoma of the kidney (2), undifferentiated sarcoma (2), immature teratoma (1), peritoneal serous carcinoma (1), malignant rhabdoid of the kidney (1), malignant germ cell tumor (1), neuroblastoma (1), and epithelioid inflammatory myofibroblast sarcoma (1). Seven patients underwent initial operation, and 12 patients received reoperation for tumor recurrence. The median peritoneal carcinomatosis index was 5 (range, 2–21). There were no perioperative deaths or life-threatening complications of CRS and HIPEC. Two patients had grade 3 complications of wound infection and wound dehiscence. With a median follow-up time of 14 months (range, 1.5–31 months), 14 patients were alive, and 5 died of tumor recurrence. Of the 14 patients who were alive, 2 relapsed after CRS and HIPEC and then received radiotherapy and molecular-targeted therapy or chemotherapy.

Conclusions

CRS and HIPEC are safe and feasible in children, without increasing serious complications in the peri- and postoperative periods. The complication is acceptable. The short-term outcome shows possible effectiveness in pediatric peritoneal malignant tumors. The long-term effectiveness needs to be verified by additional cases and long-term follow-ups.
Quality of life in dogs with idiopathic epilepsy and their owners with an emphasis on breed—A pilot study
Authors: Hamers Maud F. N. , Plonek Marta , Bhatti Sofie F. M. , Bergknut Niklas , Diaz Espineira M. Montserrat , Santifort Koen M. , Mandigers Paul J. J.
Published: January 2023

Epilepsy in dogs is a common chronic and serious disorder and may have an impact on the quality of life of the owners as well as the dogs themselves. The aim of this pilot study was to investigate the QoL score of dogs suffering from idiopathic epilepsy and their owners and if possible, investigate whether a breed specific difference exists. Owners, either Dutch or Belgium, were asked to participate in a web based SurveyMonkey questionnaire. A total of 402 questionnaires representing 402 dogs with epilepsy were suitable for further analysis. Of the 402 dogs, 253 were males and 149 were females. Ninety-nine different breeds were represented. Fourteen breeds (177 dogs in total) were used to calculate breed specific scores; Australian Shepherd (n = 8), Beagle (n = 7), Belgian Tervuren dog (n = 9), Belgian Groenendaeler dog (n = 8), Border Collie (n = 38), Chihuahua (n = 9), Dachshund (n = 13), Drentsche Patrijshond (a Dutch partridge dog) (n = 14), French Bulldog (n = 12), Golden Retriever (n = 17), Labrador Retriever (n = 18), and Rottweiler (n = 12). For the Border Collie, there was a statistically significant correlation between “epilepsy related death,” the severity of the seizures (p < 0.001) and cluster seizures (p < 0.001). The quality of life of the Border Collie was scored lower compared to all other dogs (p = 0.02). There were three breeds that had a minimal decrease in the overall quality of life score compared to all other dogs: the Chihuahua (p = 0.03), Dachshund (p = 0.001), and Golden retriever (p = 0.01). The score for “caring for my epileptic dog decreases my own QoL” was high for the Border Collie, Boxer, French Bulldog, and Rottweiler, but was only found to be statistically significantly higher in the Border Collie (p = 0.01). Scores for the Golden Retriever (p = 0.04) and Labrador (p = 0.006) were lower. In conclusion, this study reports breed specific quality of life scores of dogs with epilepsy and their owners, and underlines that breed by itself, is also an important factor when managing epilepsy in dogs.
Theoretical Contributions to Three Generalized Versions of the Celebioglu–Cuadras Copula
Authors: Chesneau Christophe
Published: January 2023

Copulas are probabilistic functions that are being used more and more frequently to describe, examine, and model the interdependence of continuous random variables. Among the numerous proposed copulas, renewed interest has recently been shown in the so-called Celebioglu–Cuadras copula. It is mainly because of its simplicity, exploitable dependence properties, and potential for applicability. In this article, we contribute to the development of this copula by proposing three generalized versions of it, each involving three tuning parameters. The main results are theoretical: they consist of determining wide and manageable intervals of admissible values for the involved parameters. The proofs are mainly based on limit, differentiation, and factorization techniques as well as mathematical inequalities. Some of the configuration parameters are new in the literature, and original phenomena are revealed. Subsequently, the basic properties of the proposed copulas are studied, such as symmetry, quadrant dependence, various expansions, concordance ordering, tail dependences, medial correlation, and Spearman correlation. Detailed examples, numerical tables, and graphics are used to support the theory.
Management of Parapharyngeal Space Tumors: Clinical Experience with a Large Sample and Review of the Literature
Authors: Jiang Chuanya , Wang Wenqian , Chen Shanwen , Liu Yehai
Published: January 2023

Parapharyngeal space (PPS) tumors are rare, and they account for 0.5–1.5% of all head and neck tumors. This study summarized the findings of large-sample clinical studies of PPS tumors and reported the clinical work-up and management of 177 cases of PPS tumors at our center. This retrospective study included patients treated for PPS tumors between 2005 and 2020 at our center. The basic characteristics, symptoms, surgical approach, complications, and recurrence rates were analyzed. A total of 99 male and 78 female patients, with a mean age of 48.3 ± 15.1 years, were enrolled in this study. The most common symptoms were external or intraoral masses (114 patients, 64%). Surgical management leveraging, a cervical approach, was used for 131 cases (74%). The tumors were benign for 92% (160 cases), with pleomorphic adenoma being the most common (88 cases, 50%). Surgical complications were reported for 31 cases (18%); facial and vocal cord paralyses were the most common. Three cases of recurrence were observed during the follow-up. PPS tumors are rare and present with atypical clinical manifestations. The current study, which involved cases in a large single center, demonstrates the importance of surgical interventions for PPS tumors. The use of endoscopic techniques has further expanded the scope of traditional surgical approaches and demonstrated its advantages in selected cases.
Novel Approach to Improving Specialist Access in Underserved Populations with Suspicious Oral Lesions
Authors: Nguyen James , Yang Susan , Melnikova Anastasya , Abouakl Mary , Lin Kairong , Takesh Thair , Wink Cherie , Le Anh , Messadi Diana , Osann Kathryn , Wilder-Smith Petra
Published: January 2023

Late detection and specialist referral result in poor oral cancer outcomes globally. High-risk LRMU populations usually do not have access to oral medicine specialists, a specialty of dentistry, whose expertise includes the identification, treatment, and management of oral cancers. To overcome this access barrier, there is an urgent need for novel, low-cost tele-health approaches to expand specialist access to low-resource, remote and underserved individuals. The goal of this study was to compare the diagnostic accuracy of remote versus in-person specialist visits using a novel, low-cost telehealth platform consisting of a smartphone-based, remote intraoral camera and custom software application. A total of 189 subjects with suspicious oral lesions requiring biopsy (per the standard of care) were recruited and consented. Each subject was examined, and risk factors were recorded twice: once by an on-site specialist, and again by an offsite specialist. A novel, low-cost, smartphone-based intraoral camera paired with a custom software application were utilized to perform synchronous remote video/still imaging and risk factor assessment by the off-site specialist. Biopsies were performed at a later date following specialist recommendations. The study’s results indicated that on-site specialist diagnosis showed high sensitivity (94%) and moderate specificity (72%) when compared to histological diagnosis, which did not significantly differ from the accuracy of remote specialist telediagnosis (sensitivity: 95%; specificity: 84%). These preliminary findings suggest that remote specialist visits utilizing a novel, low-cost, smartphone-based telehealth tool may improve specialist access for low-resource, remote and underserved individuals with suspicious oral lesions.
Causal Confirmation Measures: From Simpson’s Paradox to COVID-19
Authors: Lu Chenguang
Published: January 2023

When we compare the influences of two causes on an outcome, if the conclusion from every group is against that from the conflation, we think there is Simpson’s Paradox. The Existing Causal Inference Theory (ECIT) can make the overall conclusion consistent with the grouping conclusion by removing the confounder’s influence to eliminate the paradox. The ECIT uses relative risk difference Pd = max(0, (R − 1)/R) (R denotes the risk ratio) as the probability of causation. In contrast, Philosopher Fitelson uses confirmation measure D (posterior probability minus prior probability) to measure the strength of causation. Fitelson concludes that from the perspective of Bayesian confirmation, we should directly accept the overall conclusion without considering the paradox. The author proposed a Bayesian confirmation measure b* similar to Pd before. To overcome the contradiction between the ECIT and Bayesian confirmation, the author uses the semantic information method with the minimum cross-entropy criterion to deduce causal confirmation measure Cc = (R − 1)/max(R, 1). Cc is like Pd but has normalizing property (between −1 and 1) and cause symmetry. It especially fits cases where a cause restrains an outcome, such as the COVID-19 vaccine controlling the infection. Some examples (about kidney stone treatments and COVID-19) reveal that Pd and Cc are more reasonable than D; Cc is more useful than Pd.
Image Restoration Quality Assessment Based on Regional Differential Information Entropy
Authors: Wang Zhiyu , Zhuang Jiayan , Ye Sichao , Xu Ningyuan , Xiao Jiangjian , Peng Chengbin
Published: January 2023

With the development of image recovery models, especially those based on adversarial and perceptual losses, the detailed texture portions of images are being recovered more naturally. However, these restored images are similar but not identical in detail texture to their reference images. With traditional image quality assessment methods, results with better subjective perceived quality often score lower in objective scoring. Assessment methods suffer from subjective and objective inconsistencies. This paper proposes a regional differential information entropy (RDIE) method for image quality assessment to address this problem. This approach allows better assessment of similar but not identical textural details and achieves good agreement with perceived quality. Neural networks are used to reshape the process of calculating information entropy, improving the speed and efficiency of the operation. Experiments conducted with this study’s image quality assessment dataset and the PIPAL dataset show that the proposed RDIE method yields a high degree of agreement with people’s average opinion scores compared with other image quality assessment metrics, proving that RDIE can better quantify the perceived quality of images.
Structural Competency: A Framework for Racial Justice Intervention in Student Affairs Preparation and Practice
Authors: Whitman Kenyon Lee , Jayakumar Uma Mazyck
Published: January 2023

Higher education practices and policies are rooted in racism and imperialism. This causes physical and emotional harm to BIPOC students. Yet, student affairs practitioners and higher education leaders struggle to stay conscious of the relationships between macro structures of oppression and their deleterious educational, economic, health, and social consequences, when it comes time to assess, understand, and intervene in campus crises and racialized violence. Borrowing from the medical field, this paper offers “structural competency” as a framework for student affairs education and practice toward supporting practitioners prepared to mitigate systemic racism and to identify the social determinants of inequity. Structural competency in student affairs means having the capacity to understand and take actions toward addressing the root causes of BIPOC students’ marginalization in historically white campus contexts. It requires deep attention to how these causes—polices, institutional norms, infrastructures, and the hegemonic beliefs embedded in our economic, social, and political systems—interact with students’ lived experiences on campus. Guided by a Critical Race Theory lens, structural competency moves us toward confronting the downstream consequences of upstream decisions such as admissions standards that disenfranchise BIPOC students, or how the federal financial aid formula fails to account for equity in home ownership which disproportionately harms Black families for the benefit of white ones, because of antiblack U.S. policies such as redlining, making college less accessible for BIPOC students. This paper argues that such a structural competency framework and mindset in policy and practice is crucial for higher education leaders confronting systemic institutional policies that have a cumulative and ongoing oppressive impact on BIPOC students.
Evaluating the Potential of Multi-Anodes in Constructed Wetlands Coupled with Microbial Fuel Cells for Treating Wastewater and Bioelectricity Generation under High Organic Loads
Authors: Tamta Prashansa , Rani Neetu , Mittal Yamini , Yadav Asheesh Kumar
Published: January 2023

Multiple anodes can significantly enhance the treatment potential of constructed wetlands coupled with a microbial fuel cell (CW-MFC) system, which has not yet been explored. Thus, the present study evaluates the potential of multi-anodes and single cathode-based CW-MFC at significantly higher organic loading rates for treatment performance and bioelectricity generation. For this purpose, two identical but different materials, i.e., graphite granules (GG) and granular activated charcoal (GAC), were used to set up multiple anodes and single cathode-based CW-MFCs. The graphite granules (GG)-based system is named CW-MFC (GG), and the granular activated charcoal (GAC) based system is named as CW-MFC (GAC). These systems were evaluated for chemical oxygen demand (COD), NH4+-N removal efficiency, and electrical output at relatively higher organic loading rates of 890.11 g COD/m3-d and 1781.32 g COD/m3-d. At an OLR of 890.11 g COD/m3-d, the treatment efficiency was found to be 24.8% more in CW-MFC (GAC) than CW-MFC (GG), whereas it was 22.73% more for CW-MFC (GAC) when OLR was increased to 1781.32 g COD/m3-d. Whereas, NH4+-N removal efficiency was more in CW-MFC (GG) i.e., 56.29 ± 7% and 56.09 ± 3.9%, compared to CW-MFC (GAC) of 36.59 ± 3.8% and 50.59 ± 7% at OLR of 890.11 g COD/m3-d and 1781.32 g COD/m3-d, respectively. A maximum power density of 48.30 mW/m3 and a current density of 375.67 mA/m3 was produced for CW-MFC (GAC) under an organic loading rate of 890.11 g COD/m3-d.
Performance Analysis of Low-Capacity Water–LiBr Absorption–Cooling Systems Using Geothermal Heat-Sinks in Hot Climates
Authors: Ketfi Omar , Abdi Hamid , Lounici Billel , Bourouis Mahmoud
Published: January 2023

This paper addresses the use of a geothermal heat-sink to remove the heat released in domestic-sized single and double-effect water–LiBr absorption chillers operating in hot climates. This study is the continuation of a previous work, which demonstrated the operational constraints of these absorption chillers working in hot Algerian climate-zones. After localizing the non-operation zones for both systems, the thermo-physical properties of the soil at several depths are investigated for the implementation of the underground heat-exchanger. This heat-exchanger is connected to the condenser and the absorber of both systems, to supply cooling water at inlet temperatures of 33 °C in hot climate conditions, with ambient temperatures varying from 38 °C to 42 °C. The results show a steady operation for both absorption chillers in climate conditions which had not previously allowed the two systems to operate in water or air-cooled modes. A maximum coefficient of performance of 0.76 and 1.25 is obtained for single- and double-effect absorption cycles, respectively, with chilled water at 7 °C. The underground-tube length required is between 4.5 and 18 m, depending on the absorption-cycle configuration and the temperature of the chilled water.
Solar and Wind Energy Integrated System Frequency Control: A Critical Review on Recent Developments
Authors: Alam Md. , Chowdhury Tanzi , Dhar Abhishak , Al-Ismail Fahad , Choudhury M. , Shafiullah Md , Hossain Md. , Hossain Md. , Ullah Aasim , Rahman Syed
Published: January 2023

A paradigm shift in power systems is observed due to the massive integration of renewable energy sources (RESs) as distributed generators. Mainly, solar photovoltaic (PV) panels and wind generators are extensively integrated with the modern power system to facilitate green efforts in the electrical energy sector. However, integrating these RESs destabilizes the frequency of the modern power system. Hitherto, the frequency control has not drawn sufficient attention due to the reduced inertia and complex control of power electronic converters associated with renewable energy conversion systems. Thus, this article provides a critical summary on the frequency control of solar PV and wind-integrated systems. The frequency control issues with advanced techniques, including inertia emulation, de-loading, and grid-forming, are summarized. Moreover, several cutting-edge devices in frequency control are outlined. The advantages and disadvantages of different approaches to control the frequency of high-level RESs integrated systems are well documented. The possible improvements of existing approaches are outlined. The key research areas are identified, and future research directions are mentioned so that cutting-edge technologies can be adopted, making the review article unique compared to the existing reviews. The article could be an excellent foundation and guidance for industry personnel, researchers, and academicians.
Hydrodynamics of Energy-Efficient Axial-Flow Cyclones for Environmentally Safe Cleaning of Gas and Dust Emissions
Authors: Meshalkin Valery , Martsulevich Nicolay , Flisyuk Oleg , Likhachev Ilia , Nzioka Antony
Published: January 2023

We investigated the operation of an axial-flow cyclone as the most promising dust-cleaning equipment based on energy consumption. Numerical solutions were obtained for the gas-solids suspension flow equations in axial flow cyclones with different separation chambers’ geometry using FlowVision software. The chamber’s geometrical features determined the nature of the gas-solids suspension flow, directly affecting the dusty gases’ purification degree. The circulating gas flows and the turbulent “trace” after the swirl generator were found to negatively influence the cyclone efficiency and the hydraulic resistance values. A high chamber height also negatively affected the gas purification since the bulk of dust particles were removed from the gas-solids flow at the initial section. The initial section’s length coincided with the gas-solids suspension’s jet flow zone due to the flow coming off the swirl vanes’ edges. Due to turbulent mixing, the particles’ secondary entrainment and return to the gas flow began to manifest outside this zone. Based on this analysis, it is possible to develop recommendations for choosing the chamber’s geometric parameters, minimizing the influence of the indicated factors. On the basis of this research, it will be possible to ensure cyclones’ high efficiency with significantly lower hydraulic resistance when designing axial-flow cyclones relative to other types of cyclone.
Design of Variable Pitch Control Method for Floating Wind Turbine
Authors: Yuan Jiawang , Cheng Zhijiang , Liu Dengquan
Published: January 2023

Because of the randomness of wind speed and the nonlinearity of the dynamic equation of variable pitch control, it is difficult to establish an accurate dynamic equation of variable pitch of floating fan. In view of this situation, this paper takes the 5 MW floating wind turbine of the NREL (National Renewable Energy Laboratory) as the research object, establishes the dynamic equation under the basic control of FAST, uses the L-M (nonlinear least square method) to identify the dynamic parameters of the system and obtains the dynamic model of the floating fan under variable pitch stability control. Compared with the output of FAST in the same case, the accuracy of the control model is verified; the FAST base pitch control adopts PI control, but the effect of FAST base control is relatively poor. This paper proposes a disturbance-adaptive pitch control method based on fractional PID feedback; the results show that compared with the FAST base pitch control, the control method is more suitable for variable pitch control of a floating wind turbine. The generating power is more stable, the overshoot of generating power is smaller and the fluctuation of wind speed is smaller. Except for surge and heave, the fluctuation of the other four degrees of the freedom of the floating wind turbine platform is reduced, making it more suitable for the variable pitch control of the floating wind turbine.
Energy-Consumption Pattern-Detecting Technique for Household Appliances for Smart Home Platform
Authors: Caldera Matteo , Hussain Asad , Romano Sabrina , Re Valerio
Published: January 2023

Rising electricity prices and the greater penetration of electricity consumption in end-uses have prompted efforts to set up data-driven methodologies to optimise energy consumption and foster user engagement in demand-side management strategies. The performance of energy-management systems is greatly affected by the consumer behaviors and the adopted energy-management methodology. Consequently, it is necessary to develop appliance-level, detailed energy-consumption information models to inform citizens to improve behaviors toward energy use. The goal of the Home Energy Management System (HEMS) is to foster an ecosystem that is energy-optimized and can manage Internet of things (IoT) equipment over its network. HEMS allows consumers to reduce energy costs by adapting their consumption to variable pricing over the day. With the use of descriptive data-mining techniques, we have developed a numerical model that gives consumers access to information on their domestic appliances with regard to the number and duration of operations, cycles disaggregation for appliances that have cyclic operation (e.g., washing machine, dishwasher), and energy consumption throughout various time periods basing on 15-min monitoring data. The model has been calibrated and validated on two datasets collected by ENEA by real-time monitoring of Italian dwellings and has been tested over several appliances showing effective analysis of the energy-consumption patterns. Therefore, it has been integrated in the DHOMUS IoT platform, developed by ENEA to monitor and analyse the energy consumption in dwellings in order to increase citizens’ engagement and awareness of their energy consumption. The results indicate that the developed model is sufficiently accurate, and that it is possible to promote a more virtuous and sustainable use of energy by end users, as well as to reduce the energy demand as required by the current European Council Regulation (EU) 2022/1854.
A Parametric Design Method for the Lighting Environment of a Library Building Based on Building Performance Evaluation
Authors: Liu Qibo , Han Xiao , Yan Yuheng , Ren Juan
Published: January 2023

The lighting conditions of a library directly affect the users’ spatial experience, with glass curtain walls being widely used in the design of library skins. Although glass curtain walls have been extensively adopted, they increase indoor sun exposure and glare. Considering sunlight duration and radiation as the design basis, this study employs the Rhino and Grasshopper parametric platforms to parametrically design a library with a dynamic shading skin. Specifically, our design utilizes modular shading components that can change depending on the simulated sunlight data at different times. Additionally, a new optimal design strategy has been developed to enhance the environmental lighting performance of the library. The simulation results highlight that the indoor environmental lighting performance, under dynamic epidermal shading and based on sunlight duration data, is better for east–west, north–south, and east–west orientations on the summer solstice and the winter solstice. Meanwhile, the indoor environmental lighting performance, under dynamic epidermal shading based on daylight radiation data, is better for north–south orientation on the winter solstice. Overall, this study uses parameterization to integrate building simulation and architectural design to improve a building’s lighting performance.
2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection—Exploring the Role of the Red Blood Cell Membrane
Authors: Carvalho Maria , Medeiros Márcia M. , Morais Inês , Lopes Catarina S. , Balau Ana , Santos Nuno C. , Carvalho Filomena A. , Arez Ana Paula
Published: January 2023

Malaria remains a major world public health problem, contributing to poverty and inequality. It is urgent to find new efficacious tools with few adverse effects. Malaria has selected red blood cell (RBC) alterations linked to resistance against infection, and understanding the protective mechanisms involved may be useful for developing host-directed tools to control Plasmodium infection. Pyruvate kinase deficiency has been associated with resistance to malaria. Pyruvate kinase-deficient RBCs display an increased concentration of 2,3-diphosphoglycerate (2,3-DPG). We recently showed that 2,3-DPG impacts in vitro intraerythrocytic parasite growth, induces a shift of the metabolic profile of infected cells (iRBCs), making it closer to that of noninfected ones (niRBCs), and decreases the number of parasite progenies that invade new RBCs. As an increase of 2,3-DPG content may also have an adverse effect on RBC membrane and, consequently, on the parasite invasion, in this study, we explored modifications of the RBC morphology, biomechanical properties, and RBC membrane on Plasmodium falciparum in vitro cultures treated with 2,3-DPG, using atomic force microscopy (AFM)-based force spectroscopy and other experimental approaches. The presence of infection by P. falciparum significantly increased the rigidity of parasitized cells and influenced the morphology of RBCs, as parasitized cells showed a decrease of the area-to-volume ratio. The extracellular addition of 2,3-DPG also slightly affected the stiffness of niRBCs, making it more similar to that of infected cells. It also changed the niRBC height, making the cells appear more elongated. Moreover, 2,3-DPG treatment influenced the cell surface charge, becoming more negative in treated RBCs than in untreated ones. The results indicate that treatment with 2,3-DPG has only a mild effect on RBCs in comparison with the effect of the presence of the parasite on the host cell. 2,3-DPG is an endogenous host metabolite, which may, in the future, originate a new antimalarial tool with few adverse effects on noninfected cells.
Adjustment of the Structure of the Simplest Amino Acid Present in Nature—Glycine, toward More Environmentally Friendly Ionic Forms of Phenoxypropionate-Based Herbicides
Authors: Olejniczak Adriana , Stachowiak Witold , Rzemieniecki Tomasz , Niemczak Michał
Published: January 2023

The use of chemicals for various purposes in agriculture has numerous consequences, such as the contamination of ecosystems. Thus, nowadays it is perceived that their development should adhere to the principles of green chemistry elaborated by Paul Anastas. Consequently, to create more environment-friendly herbicides, we elaborated a ‘green’ synthesis method of a series of ionic liquids (ILs) containing cations derived from glycine. The appropriately modified cations were combined with an anion from the group of phenoxy acids, commonly known as 2,4-DP. The products were obtained with high yields, and subsequently, their properties, such as density, viscosity and solubility, were thoroughly examined to elucidate existing structure–property relationships. All ILs were liquids at room temperature, which enabled the elimination of some serious issues associated with solid active forms, such as the polymorphism or precipitation of an active ingredient from spray solution. Additionally, the synthesized compounds were tested under greenhouse conditions, which allowed an assessment of their effectiveness in regulating the growth of oilseed rape, selected as a model dicotyledonous plant. The product comprising a dodecyl chain exhibited the greatest reduction in the fresh weight of plants, significantly surpassing not only a commercially used reference herbicide but also the potassium salt of 2,4-DP.
Folic-Acid-Conjugated Thermoresponsive Polymeric Particles for Targeted Delivery of 5-Fluorouracil to CRC Cells
Authors: Milewska Sylwia , Siemiaszko Gabriela , Wilczewska Agnieszka Zofia , Misztalewska-Turkowicz Iwona , Markiewicz Karolina Halina , Szymczuk Dawid , Sawicka Diana , Car Halina , Lazny Ryszard , Niemirowicz-Laskowska Katarzyna
Published: January 2023

Colorectal cancer is the fourth most common cancer worldwide and the third most frequently diagnosed form of cancer associated with high mortality rates. Recently, targeted drug delivery systems have been under increasing attention owing to advantages such as high therapeutic effectiveness with a significant depletion in adverse events. In this report, we describe the biocompatible and thermoresponsive FA-conjugated PHEA-b-PNIPAAm copolymers as nanocarriers for the delivery of 5-FU. The block copolymers were obtained using RAFT (Reversible Addition–Fragmentation chain Transfer) polymerization and were characterized by methods such as SEC (Size Exclusion Chromatography), NMR (Nuclear Magnetic Resonance), UV–Vis (Ultraviolet–Visible), FT-IR (Fourier Transform Infrared) spectroscopy, and TGA (Thermogravimetric Analysis). Nanoparticles were formed from polymers with and without the drug-5-fluorouracil, which was confirmed using DLS (Dynamic Light Scattering), zeta potential measurements, and TEM (Transmission Electron Microscopy) imaging. The cloud points of the polymers were found to be close to the temperature of the human body. Eventually, polymeric carriers were tested as drug delivery systems for the safety, compatibility, and targeting of colorectal cancer cells (CRC). The biological evaluation indicated high compatibility with the representative host cells. Furthermore, it showed that proposed nanosystems might have therapeutic potential as mitigators for 5-FU-induced monocytopenia, cardiotoxicity, and other chemotherapy-associated disorders. Moreover, results show increased cytotoxicity against cancer cells compared to the drug, including a line with a drug resistance phenotype. Additionally, the ability of synthesized carriers to induce apoptosis and necrosis in treated CRC cells has been confirmed. Undoubtedly, the presented aspects of colorectal cancer therapy promise future solutions to overcome the conventional limitations of current treatment regimens for this type of cancer and to improve the quality of life of the patients.
The polyHIS Tract of Yeast AMPK Coordinates Carbon Metabolism with Iron Availability
Authors: Simpson-Lavy Kobi J. , Kupiec Martin
Published: January 2023

Energy status in all eukaryotic cells is sensed by AMP-kinases. We have previously found that the poly-histidine tract at the N-terminus of S. cerevisiae AMPK (Snf1) inhibits its function in the presence of glucose via a pH-regulated mechanism. We show here that in the absence of glucose, the poly-histidine tract has a second function, linking together carbon and iron metabolism. Under conditions of iron deprivation, when different iron-intense cellular systems compete for this scarce resource, Snf1 is inhibited. The inhibition is via an interaction of the poly-histidine tract with the low-iron transcription factor Aft1. Aft1 inhibition of Snf1 occurs in the nucleus at the nuclear membrane, and only inhibits nuclear Snf1, without affecting cytosolic Snf1 activities. Thus, the temporal and spatial regulation of Snf1 activity enables a differential response to iron depending upon the type of carbon source. The linkage of nuclear Snf1 activity to iron sufficiency ensures that sufficient clusters are available to support respiratory enzymatic activity and tests mitochondrial competency prior to activation of nuclear Snf1.
Optical Fiber Grating-Prism Fabrication by Imprint Patterning of Ionic-Liquid-Based Resist
Authors: Turek Natalia , Pala Piotr , Szpecht Andrea , Zając Adrian , Sembratowicz Teresa , Martynkien Tadeusz , Śmiglak Marcin , Komorowska Katarzyna
Published: January 2023

We present a method of microstructure fabrication on the tip of the optical fiber using a UV soft-imprint process of polymerizable ionic liquid-based optical resist. Ionic liquid with two UV-sensitive vinylbenzyl groups in the structure was diluted in non-hazardous propylene glycol (PG) to obtain liquid material for imprinting. No additional organic solvent was required. The impact of propylene glycol amount and exposure dose on optical and mechanical properties was investigated. The final procedure of the UV imprint on the optical fiber tip was developed, including the mold preparation, setup building, UV exposure and post-laser cure. As the IL-containing vinylbenzyl groups can also be polymerized by the radical rearrangement of double bonds through thermal heating, the influence of the addition of 1–2% BHT polymerization inhibitor was verified. As a result, we present the fabricated diffraction gratings and the optical fiber spectrometer component—grism (grating-prism), which allows obtaining a dispersion spectrum at the output of an optical in line with the optical fiber long axis, as the main component in an optical fiber spectrometer. The process is very simple due to the fact that its optimization already starts in the process of molecule design, which is part of the trend of sustainable technologies. The final material can be designed by the tailoring of the anion and/or cation molecule, which in turn can lead to a more efficient fabrication procedure and additional functionalities of the final structure.
The Diffusion Model of Intra-Golgi Transport Has Limited Power
Authors: Beznoussenko Galina V. , Bejan Andrei Iu. , Parashuraman Seetharaman , Luini Alberto , Kweon Hee-Seok , Mironov Alexander A.
Published: January 2023

The Golgi complex (GC) is the main station along the cell biosecretory pathway. Until now, mechanisms of intra-Golgi transport (IGT) have remained unclear. Herein, we confirm that the goodness-of-fit of the regression lines describing the exit of a cargo from the Golgi zone (GZ) corresponds to an exponential decay. When the GC was empty before the re-initiation of the intra-Golgi transport, this parameter of the curves describing the kinetics of different cargoes (which are deleted in Golgi vesicles) with different diffusional mobilities within the GZ as well as their exit from the GZ was maximal for the piecewise nonlinear regression, wherein the first segment was horizontal, while the second segment was similar to the exponential decay. The kinetic curve describing cargo exit from the GC per se resembled a linear decay. The Monte-Carlo simulation revealed that such curves reflect the role of microtubule growth in cells with a central GC or the random hovering of ministacks in cells lacking a microtubule. The synchronization of cargo exit from the GC already filled with a cargo using the wave synchronization protocol did not reveal the equilibration of cargo within a Golgi stack, which would be expected from the diffusion model (DM) of IGT. Moreover, not all cisternae are connected to each other in mini-stacks that are transporting membrane proteins. Finally, the kinetics of post-Golgi carriers and the important role of SNAREs for IGT at different level of IGT also argue against the DM of IGT.