bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Host—Guest Interactions for Tuning the Magnetic Coupling in Metal Ion Clusters
Authors: Abbati G. L. , Caneschi A. , Cornia A. , Fabretti A. C. , Gatteschi D.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dithiadiazolyl Radicals as Molecular Bricks for High Tc Organic Magnets
Authors: Antorrena Guillermo , Palacio Fernando , Rawson Jeremy M. , Smith J. Nicholas B.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: SASRIN, a Versatile Tool in Peptide Synthesis and Solid‐Phase Organic Chemistry
Authors: Mergler Monika , Gosteli Jacques , Grogg Peter , Nyfeler Rolf , Tanner Rudolf
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sugars Slide into Heparin Activity
Authors: Sinay Pierre
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Multi‐Component Methodologies in Solid‐Phase Organic Synthesis
Authors: Dax Scott L. , McNally James J. , Youngman Mark A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Inhibitors of 17α‐Hydroxylase/17,20‐Lyase (CYP17): Potential Agents for the Treatment of Prostate Cancer
Authors: Njar V. C. O. , Brodie A. M. H.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ring‐B Modified Anthracyclines
Authors: Suarato Antonino , Angelucci Francesco , Geroni Cristina
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2,3,4,5‐Tetrahydropyridine (Δ1‐Piperideine) and Its Derivatives. Synthesis and Chemical Properties
Authors: Shvekhgeimer M.‐G. A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Non‐Innocent Ligand in Coordination Chemistry: The Dithiolene Complexes
Authors: Fourmigue Marc , Domercq Benoit
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solid‐Phase Synthesis on Planar Supports
Authors: Lebl Michal
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Totally Enzymic Synthesis of Peptides: Penicillin Acylase Catalyzed Protection and Deprotection of Amino Groups as Important Building Blocks of This Strategy
Authors: Svedas Vytas K. , Beltser Alexander I.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New and Efficient Catalysts for Enantioselective Borohydride Reduction of Ketones and Imines
Authors: Nagata Takushi , Sugi Kiyoaki D. , Yorozu Kiyotaka , Yamada Tohru , Mukaiyama Teruaki
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Relocalization in Floppy Hydrocarbon Radicals
Authors: Cooksy A. L.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Prediction of Vibrational Spectra: The Use of Scale Factors
Authors: Alcolea Palafox Mauricio
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: CIDNP Studies of Electron and Proton Transfer Reactions of Radical Cations
Authors: Goez Martin
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: What Can We Learn from Nature about the Reactivity of Coordinated Phenoxyl Radicals? — A Bioinorganic Success Story
Authors: Krueger Hans‐Joerg
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Interaction of Hydrocarbons with Partial Oxidation Catalysts
Authors: Margolis L. Ya. , Korchak V. N.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cambridge Structural Database as a Tool for Studies of General Structural Features of Organic Molecular Crystals
Authors: Kuleshova L. N. , Antipin M. Yu.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reversible Encapsulation and Its Consequences in Solution
Authors: Rebek Jr. Julius
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unfolding, Refolding, and Hydration of Proteins in the Gas Phase
Authors: Jarrold Martin F.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrogen Bonding in Substituted‐Ammonium Salts of the Tetracarbonylcobaltate(‐I) Anion: Some Insights into Potential Roles for Transition Metals in Organometallic Crystal Engineering
Authors: Mareque Rivas Juan C. , Brammer Lee
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrogen and Fluorine in Crystal Engineering: Systematics from Crystallographic Studies of Hydrogen Bonded Tartrate—Amine Complexes and Fluoro‐Substituted Coumarins, Styrylcoumarins and Butadienes
Authors: Guru Row T. N.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Photochemical Synthesis of α,α,α‐Bromodifluorotoluene and α,α,α‐Chlorodifluorotoluene.
Authors: He Jinbao , Pittman Jr. Charles U.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐Methylanilines from Benzylic Azides.
Authors: Lopez Francisco J. , Nitzan Dov
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Enantiopure β‐ and γ‐Amino Alcohols from Homochiral α‐ and β‐Aminoacylsilanes as Stable Synthetic Equivalents of α‐ and β‐Amino Aldehydes.
Authors: Bonini Bianca Flavia , Comes‐Franchini Mauro , Fochi Mariafrancesca , Gawronski Jacek , Mazzanti Germana , Ricci Alfredo , Varchi Greta
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium Chloride and Tetraphenylphosphonium Bromide Intercalated Clay as a New Catalyst for the Heck Reaction.
Authors: Varma Rajender S. , Naicker Kannan P. , Liesen Per J.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: [4 + 3] Cycloaddition Reactions: Synthesis of 9,10‐Dimethoxy‐9,10‐propanoanthracen‐12‐ones.
Authors: Sarhan Abd El‐Wareth A. O.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Adventitious Synthesis of 2,2′‐Dipyrryl Disulfides.
Authors: Adhikari Raju , Jones Dionne , Liepa Andris J. , Mackay Maureen F.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Optically Active 2‐Chloromethyl‐2‐oxazolines by the Ortho‐Ester Condensation Method Using Triethyl Orthochloroacetate.
Authors: Kamata Kazuyuki , Sato Hideki , Takagi Emi , Agata Isao , Meyers A. I.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Synthesis of Protected Methyl 4‐Hydroxy‐1,2,3,4‐tetrahydroisoquinoline‐3‐carboxylate via Cleavage of Functionalized Dihydrooxazoles (Oxazolines).
Authors: Lerestif Jean Michel , Feuillet Soazig , Bazureau Jean Pierre , Hamelin Jack
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of Chiral, Nonracemic Trifluoromethyl‐Substituted Piperidines and Decahydroquinolines.
Authors: Jiang Jinlong , DeVita Robert J. , Doss George A. , Goulet Mark T. , Wyvratt Matthew J.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Metalation of γ‐Carbolines.
Authors: Papamicael Cyril , Dupas Georges , Queguiner Guy , Bourguignon Jean
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Alkylation of 1‐(3,4‐Disubstituted Phenyl)‐2‐thioxo‐1,2,5,6‐tetrahydropyrimidin‐4(3H)‐ones.
Authors: Kantminiene Kristina , Beresnevicius Zigmuntas , Mikulskiene Gema , Kihlberg Jan , Broddefalk Johan
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 1,3‐Dinitrotetrahydropyrimidines.
Authors: Bakke Jan M. , Riha Jaroslav
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of an Antioxidant Having a Dibenz[b,f]oxepine Skeleton.
Authors: Jinno Shuji , Okita Takaaki
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1H‐1,3‐Benzazaphospholes: The Organometallic Route and a New Three‐Step Synthesis with Reductive Ring Closure.
Authors: Bansal Raj K. , Gupta Neelima , Heinicke Joachim , Nikonov George N. , Saguitova Farida , Sharma Dinesh C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2‐Nitroferrocenyloxazolines: Precursors to Nitrofulvalenes and Derivatives of (pS)‐ and (pR)‐2‐Aminoferrocenecarboxylic Acids.
Authors: Salter Rhys , Pickett Tom E. , Richards Christopher J.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Triterpenoid Saponins from Bupleurum subovatum (Link) (Umbelliferae).
Authors: Anam Edet M.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Strategy for the Synthesis of Spiro[4,5]decanes: A Formal Total Synthesis of Acorone.
Authors: Biju P. John , Subba Rao G. S. R.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Studies on Natural Products. Part 7. Conversion of Parthenin to Anhydroparthenin Using Microwave Irradiation.
Authors: Das Biswanath , Venkataiah B.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Oxidation of Some Steroidal Dienes by Potassium Permanganate/Copper Sulfate.
Authors: Hanson James R. , Hitchcock Peter B. , Nagaratnam Sivajini
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Silane Reduction of Aromatic Ketones Mediated by Titanium Tetrachloride: A Synthesis of γ‐ and δ‐Aryl Substituted Amino Acids.
Authors: Yato Michihisa , Homma Koichi , Ishida Akihiko
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Unconventional Method for Purifying the N‐Carboxyanhydride Derivatives of γ‐Alkyl‐L‐glutamates.
Authors: Poche Drew S. , Moore Michael J. , Bowles Jennifer L.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organotransition Metal Modified Sugars. Part 10. Chromium Iminoglycosylidenes: Synthesis and Application to Photoinduced C‐Glycosidation.
Authors: Doetz Karl Heinz , Klumpe Markus , Nieger Martin
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Synthesis of 6‐Alkynyl‐6‐deoxy and Pseudo‐C‐disaccharides Derivatives of Mannofuranose via a 5,6‐Cyclic Sulfate.
Authors: Gourlain Thierry , Wadouachi Anne , Beaupere Daniel
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Synthesis of Sugar Esters Without Catalyst Using α‐Hydroxycarboxylic Acids.
Authors: Bromann Regina , Koenig Burkhard , Fischer Lutz
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Total Syntheses of Ircinal A and Related Manzamine Alkaloids.
Authors: Martin Stephen F. , Humphrey John M. , Ali Amjad , Hillier Michael C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Expedient Synthesis of (.+‐.)‐γ‐Lycorane.
Authors: Hoang‐Cong Xuan , Quiclet‐Sire Beatrice , Zard Samir Z.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Potential Silicon‐Containing Antifolates.
Authors: Taylor Edward C. , Chaudhuri Rajendra P. , Watson Samuel E.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the Common C.1—C.13 Hydrophobic Domain of the B‐Type Amphidinolides.
Authors: Eng Hugo M. , Myles David C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Absolute Configuration of Falcarinol, a Potent Antitumor Agent Commonly Occurring in Plants.
Authors: Zheng Guangrong , Lu Wei , Aisa Haji A. , Cai Junchao
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Pharmacological Activities of Novel 3‐(Isoxazol‐3‐yl)‐quinazolin‐4(3H)‐one Derivatives.
Authors: Daidone Giuseppe , Raffa Demetrio , Maggio Benedetta , Plescia Fabiana , Cutuli Vincenza Maria Catena , Mangano Nunzio Guido , Caruso Antonina
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Processing and Characterization of Microemulsion‐Derived Lead Magnesium Niobate.
Authors: Ng Wei Beng , Wang John , Ng Ser Choon , Gan Leong Ming
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Ultrafine Zirconia Particles.
Authors: Xie Yuqun
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis of Germacrane Sesquiterpenes and Related Compounds
Authors: Minnaard Adriaan J. , Wijnberg Joannes B. P. A. , de Groot Aede
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Calix[8]crowns: Synthesis, Stereochemistry, and Complexing Ability
Authors: Neri Placido , Geraci Corrada , Piattelli Mario
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of [b]‐Anellated Pyrroles via an Acylation Approach
Authors: Edstrom Eric D.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chirality in Insect Juvenile Hormones and Pheromones
Authors: Mori Kenji
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carceplexes and Hemicarceplexes
Authors: Jasat Ayub , Sherman John C.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Relay Auxiliaries
Authors: Bull Steven D. , Davies Stephen G. , Fox David J. , Garner A. Christopher , Sellers Thomas G. R.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbon—Carbon Bond Formations Involving Organochromium(III) Reagents
Authors: Fuerstner Alois
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heteroatom‐Stabilized Allylic Cations in [4 + 3] Cycloaddition Reactions
Authors: Harmata Michael
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Applications of Sulfones as Cationic Reagents
Authors: Chinchilla Rafael , Najera Carmen
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Synthesis of β‐Hydroxy Acids via Chiral Enolates of Carboxylic Acids and Esters
Authors: Fringuelli Francesco , Piermatti Oriana , Pizzo Ferdinando
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of 1,4‐Dichlorobut‐2‐yne Derivatives Leading to Heterocycles
Authors: Majumdar Krishna C. , Biswas Paritosh
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2‐Pyridylthioureas: Novel Nonpeptide Somatostatin Agonists with SST4 Selectivity
Authors: Liu S. , Crider A. M. , Tang C. , Ho B. , Ankersen M. , Stidsen C. E.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Concomitant weekly cisplatin and altered fractionation radiotherapy in locally advanced head and neck cancer
Authors: Newlin Heather E. , Amdur Robert J. , Riggs Charles E. , Morris Christopher G. , Kirwan Jessica M. , Mendenhall William M.
Published: June 2010

BACKGROUND:

Both concomitant chemotherapy and altered fractionation radiotherapy (RT) have been shown to improve outcomes for patients with locoregionally advanced head and neck squamous cell carcinomas. However, both strategies also increase acute toxicity, and it is questionable whether the 2 can be safely combined. Traditional concomitant chemotherapy regimens include high‐dose cisplatin given at 100 mg/m2every 3 weeks. The authors' purpose was to report efficacy and toxicity after weekly cisplatin (30 mg/m2/wk) concurrent with altered fractionation RT.

METHODS:

One hundred twenty‐one patients with American Joint Committee on Cancer stages II (3%), III (13%), or IV (84%) squamous cell carcinomas of the oropharynx (70%), hypopharynx (20%), or larynx (10%) were treated between 2000 and 2006 at the University of Florida with hyperfractionated RT (55 patients) or concomitant boost RT (66 patients) and concomitant cisplatin (30 mg/m2/wk).

RESULTS:

Median follow‐up was 2.9 years; median follow‐up on survivors was 3.6 years. Seventy‐nine percent of patients completed ≥6 cycles of chemotherapy; 94% received ≥7200 centigrays. Seven (6%) patients changed from cisplatin to carboplatin because of bone marrow toxicity. Gastrostomy tube feeding was required in 54% of patients either before (16%) or during RT (38%). Two (1.6%) patients died from therapy‐related complications. The 5‐year outcomes were: local control, 83%; locoregional control, 79%; distant metastasis‐free survival, 88%; cause‐specific survival, 76%; and overall survival, 59%. Seven (6%) patients had severe late complications. Three (3%) patients required a permanent gastrostomy tube.

CONCLUSIONS:

Concomitant weekly cisplatin with altered fractionation RT is a safe and effective treatment regimen. Cancer 2010. © 2010 American Cancer Society.
Early alpha‐fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma
Authors: Shao Yu‐Yun , Lin Zhong‐Zhe , Hsu Chiun , Shen Ying‐Chun , Hsu Chih‐Hung , Cheng Ann‐Lii
Published: June 2010

BACKGROUND:

Antiangiogenic therapy has become the most important treatment modality for patients with advanced hepatocellular carcinoma (HCC). In this study, the authors investigated levels of alpha‐fetoprotein (AFP) as a potential biomarker for treatment efficacy of antiangiogenic therapy.

METHODS:

Patients with advanced HCC who had been enrolled in 3 prospective phase 2 clinical trials that evaluated either sorafenib, bevacizumab, or thalidomide in combination with a potentially antiangiogenic, metronomic, oral 5‐fluoropyrimidine as first‐line systemic therapy were included. An early AFP response was defined as a decline >20% from baseline after 2 to 4 weeks of treatment. AFP response was analyzed for its association with treatment efficacy and survival outcome.

RESULTS:

Seventy‐two patients were included for early AFP response evaluation, and 12 of those patients (17%) were classified as early AFP responders. Early AFP responders, compared with nonresponders, had a significantly improved overall response rate (33% vs 8%; P = .037) and a significantly improved disease control rate (83% vs 35%; P = .002), which was defined as the percentage of patients who had an objective response plus stable disease for a minimum of 8 weeks. AFP responders, compared with nonresponders, also had longer median progression‐free survival (PFS) (7.5 months vs 1.9 months; P = .001) and longer median overall survival (OS) (15.3 months vs 4.1 months; P = .019). In a multivariate analysis, AFP response remained a significant independent predictor of better PFS and OS.

CONCLUSIONS:

The current results indicated that an early AFP response is a useful surrogate marker to predict treatment response and prognosis in patients with advanced HCC who receive antiangiogenic therapy. Cancer 2010. © 2010 American Cancer Society.
Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups
Authors: Karamitopoulou Eva , Zlobec Inti , Koumarianou Anna , Patsouris Efstratios S. , Peros George , Lugli Alessandro
Published: June 2010

BACKGROUND:

The objective of identifying protein biomarkers for patients with stage III and IV colorectal cancer is to improve risk stratification and, thus, to identify patients in the postoperative setting who may benefit from more targeted treatment. The objective of the current study was to determine the prognostic value of 19 protein markers assessed in primary tumors and matched lymph node (LN) metastases from patients with stage III and IV colorectal cancer.

METHODS:

Matched primary tumors and LN metastases from 82 patients with stage III and IV colorectal cancer were mounted onto a multiple‐punch tissue microarray and were stained for 19 protein markers involved in tumor progression (β‐catenin, E‐cadherin, epidermal growth factor receptor, phosphorylated extracellular signal‐regulated kinase [pERK], receptor for hyaluronic acid‐mediated motility, phosphorylated protein kinase B, p21, p16, B‐cell lymphoma 2, Ki67, apoptotic protease activating factor 1, mammalian sterile 20‐like kinase 1, Raf kinase inhibitor protein, vascular endothelial growth factor, ephrin type‐B receptor 2, matrix metalloproteinase 7, laminin5γ2, mucin 1 [MUC1], and caudal‐related homeobox 2). The prognostic effects of biomarkers in both primary tumor and positive LNs were assessed.

RESULTS:

MUC1, pERK and p16 in LN (P = .002, P = .014, and P = .002, respectively) had independent prognostic value. In patients with stage III disease who received adjuvant treatment, negative p16 expression was associated with highly unfavorable outcomes overall (hazard ratio [HR], 0.26; 95% confidence interval [CI], 0.1‐0.6; P = .005) when the analysis was stratified by pathologic tumor classification (HR, 0.25; 95% CI, 0.1‐0.7; P = .005), age (HR, 0.23; 95% CI, 0.1‐0.6; P = .004), and LN ratio (HR, 0.26; 95% CI, 0.1‐0.7; P = .007); and, in multivariate analysis, it was associated with performance status and the receipt of folic acid treatment (HR, 0.29; 95% CI, 0.09‐0.89; P = .03).

CONCLUSIONS:

The loss of p16 in LN metastases contributed to adverse outcomes in adjuvantly treated patients with stage III colorectal cancer independent of pathologic tumor classification, age, LN ratio, performance status, or folic acid treatment. The current results support the investigation of p16 as a prognostic and potential predictive biomarker for future randomized trials of patients with stage III colorectal cancer. Cancer 2010. © 2010 American Cancer Society.
Attention and working memory abilities in children treated for acute lymphoblastic leukemia
Authors: Ashford Jason , Schoffstall Corrie , Reddick Wilburn E. , Leone Christina , Laningham Fred H. , Glass John O. , Pei Deqing , Cheng Cheng , Pui Ching‐Hon , Conklin Heather M.
Published: June 2010

BACKGROUND:

To extend investigation beyond global cognitive measures prevalent in the literature, this study examined attention and working memory (WM) abilities of survivors of childhood acute lymphoblastic leukemia (ALL), the separate contributions of attention and WM to intelligence quotient (IQ), and their association with neuroimaging changes.

METHODS:

Ninety‐seven children with ALL received risk‐directed therapy based on presenting clinical and biological factors. During consolidation therapy, low‐risk patients received half the dose of intravenous methotrexate that standard‐risk/high‐risk patients received, and fewer doses of triple intrathecal therapy. Patients were classified according to end of consolidation magnetic resonance imaging scans (normal or leukoencephalopathy), and continuous measures of white matter structure were computed. As part of the protocol study, children completed cognitive assessment 2 years later (completion of therapy), using Digit Span Forward (DSF) for attention and Digit Span Backward (DSB) for WM.

RESULTS:

For the total sample and the standard‐/high‐risk group, Total Digit Span (TDS), DSF, and DSB were impaired relative to norms (P <.05). In the low‐risk group, only DSB was impaired (P <.0001). Across groups, a higher percentage of patients performed below the average range (scale score <7) on DSB (66%) compared with the DSF (14%) or TDS (18%). Regression analysis indicated that DSB predicted estimated IQ (P <.05), after accounting for DSF. Leukoencephalopathy was predictive of lower TDS (P <.05).

CONCLUSIONS:

WM appears to be especially sensitive to treatment‐related changes in ALL survivors, detecting difficulties potentially missed by global intelligence measures. These findings may facilitate the identification of vulnerable neural pathways and the development of targeted cognitive interventions. Cancer 2010. © 2010 American Cancer Society.
Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas
Authors: Paun Bogdan C. , Kukuruga Debra , Jin Zhe , Mori Yuriko , Cheng Yulan , Duncan Mark , Stass Sanford A. , Montgomery Elizabeth , Hutcheon David , Meltzer Stephen J.
Published: June 2010

BACKGROUND:

Colorectal cancer (CRC) is 1 of the leading causes of death in the Western world. CRC develops from premalignant lesions, chiefly colorectal adenomas. Currently, the most accurate and recommended screening method for finding colorectal adenomas is colonoscopy performed on all individuals aged >50 years. However, the costs and risks associated with this procedure are relatively high. The objectives of the current study were to correlate epigenetic alterations that occur in normal rectal mucosa, smoking status, and age with the presence or absence of concomitant colorectal adenomas and to assess the potential clinical value of methylation in normal rectal biopsies as a screening assay for the presence of polyps and, hence, the need for a full colonoscopy.

METHODS:

One hundred thirteen normal rectal mucosal biopsies from 113 patients were studied. DNA was extracted, modified with sodium bisulfite, and subjected to real‐time quantitative, methylation‐specific polymerase chain reaction analysis for the following genes: adenomatous polyposis coli (APC); cadherin 1, type 1, E‐cadherin (epithelial) (CDH1); estrogen receptor 1 (ESR1); cytokine high in normal 1 (HIN1); hyperplastic polyposis protein 1 (HPP1); O‐6 methylguanine‐DNA methyltransferase (MGMT); neural epidermal growth factor‐like 1 (NELL1); splicing factor 3B, 14‐kDa subunit (p14); cyclin‐dependent kinase (CDK) inhibitor 2B (inhibits CDK4) (p15); retinoic acid receptor beta (RARβ); somatostatin (SST); tachykinin, precursor 1 (TAC1); and tissue inhibitor of metalloproteinase (TIMP) metallopeptidase inhibitor 3 (TIMP3). Data were then analyzed using several proprietary software programs.

RESULTS:

By using several sets of genes, clinical characteristics, and multivariate analyses, the authors developed a prediction model for the presence of concomitant colorectal adenomas at the time of rectal biopsy. They also observed strong correlations between smoking status and rectal methylation pattern and between smoking status and the presence or risk of concomitant adenomas.

CONCLUSIONS:

A prediction model was developed for the presence of colorectal adenomas based on gene methylation patterns in the normal rectum. The results indicated that these genes may be involved in early stages of adenoma formation. The observed epigenetic alterations in these markers may be caused in part by the effects of smoking and/or age. Normal rectal methylation may be useful as a biomarker for narrowing the population in need of screening colonoscopy. Cancer 2010. © 2010 American Cancer Society.
Long‐term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high‐risk, high‐grade, soft tissue sarcomas of the extremities and body wall
Authors: Kraybill William G. , Harris Jonathan , Spiro Ira J. , Ettinger David S. , DeLaney Thomas F. , Blum Ronald H. , Lucas David R. , Harmon David C. , Letson G. Douglas , Eisenberg Burton
Published: June 2010

BACKGROUND:

The use of neoadjuvant and adjuvant chemotherapy in soft tissue sarcomas is controversial. This is a report of long‐term (≥5 years) follow‐up in patients with high‐grade, high‐risk soft tissue sarcomas treated with neoadjuvant chemotherapy, preoperative radiotherapy (RT), and adjuvant chemotherapy.

METHODS:

Patients with high‐grade soft tissue sarcoma ≥8 cm in diameter of the extremities and body wall received 3 cycles of neoadjuvant chemotherapy (mesna, doxorubicin, ifosfamide, and dacarbazine) and preoperative RT (44 grays administered in split courses), and 3 cycles of postoperative chemotherapy (mesna, doxorubicin, ifosfamide, and dacarbazine).

RESULTS:

Sixty‐four of 66 patients were analyzed. After chemotherapy and RT, 61 patients had surgery; 58 had R0 resections (5 amputations), and 3 had R1 resections. Ninety‐seven percent experienced grade 3 or higher toxicity, including 3 deaths. These toxicities were short term. With a median follow‐up of 7.7 years in surviving patients, the 5‐year rates of locoregional failure (including amputation), and distant metastasis were 22.2% (95% confidence interval [CI], 11.8‐32.6) and 28.1% (95% CI, 17.0‐39.2). The most common site of metastasis was lung. Estimated 5‐year rates of disease‐free survival, distant disease‐free survival, and overall survival were 56.1% (95% CI, 43.9‐68.3), 64.1% (95% CI, 52.3‐75.8), and 71.2% (95% CI, 60.0‐82.5), respectively.

CONCLUSIONS:

Although the toxicity was significant, it was limited in its course and for the most part resolved by 1 year. The long‐term outcome was better than might be expected in such high‐risk tumors. Cancer 2010. © 2010 American Cancer Society.
Clinical utility of multiparameter flow cytometry in the diagnosis of 1013 patients with suspected myelodysplastic syndrome
Authors: Kern Wolfgang , Haferlach Claudia , Schnittger Susanne , Haferlach Torsten
Published: June 2010

BACKGROUND:

The diagnosis and classification of myelodysplastic syndromes (MDS) is based on cytomorphology (CM) and cytogenetics (CG). Multiparameter flow cytometry (MFC) may add important diagnostic information.

METHODS:

To evaluate the potential role of MFC in the diagnostic setting of MDS, the authors analyzed the results from 1013 patients with suspected MDS by using CM, CG, and MFC in parallel.

RESULTS:

Concordance between CM and MFC was 82% for diagnostic results in 788 patients who had unequivocal CM results. An additional 225 patients had only minor dysplastic features identified by CM, including 51 patients (22.7%) who had clear evidence of MDS by MFC. Twelve patients who had no indication of MDS identified by CM had MDS‐typical CG aberrations; in 6 of those patients (50%), MFC revealed MDS characteristics. In another 11 of 23 patients (47.8%) who had minor dysplastic features identified by CM and MDS‐typical CG aberrations, MFC revealed MDS characteristics. The percentages of blasts determined by CM and by MFC were strongly correlated (P < .001). The frequency of aberrantly expressed antigens differed significantly between patients rated by CM as MDS (highest frequencies), suspected MDS, and no MDS (lowest frequencies). In various patients, MFC identified MDS‐typical aberrant antigen expression in cell compartments that were not rated dysplastic by CM. The numbers of aberrantly expressed antigens were correlated with International Prognostic Scoring System scores and overall survival.

CONCLUSIONS:

The current analysis clearly demonstrated an increased diagnostic yield with MFC when added to CM and CG in patients with suspected MDS. Cancer 2010. © 2010 American Cancer Society.