bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of an innovative model of community nursing for older adults based on Buurtzorg principles: a scoping review protocol
Authors: de Andrade Iohana Cristina Salla , Tosin Michelle Hyczy de Siqueira , Oliveira Martha , Nandram Sharda , Pinheiro Fernanda Gomes de Magalhães Soares , Oliveira Beatriz Guitton Renaud Baptista de
Published: September 2022

Objective:

The objective of this review is to map the international evidence on the implementation of the Buurtzorg model of community nursing practice for the care of older adults. We will describe where and how it has been used, and what the challenges and facilitators of implementing this model of care are.

Introduction:

The challenges of aging have mobilized health systems around the world to replace the current facility- and disease-centered care model with integrated patient-centered care models. The Buurtzorg model provides autonomy to nurses, who, in turn, empower patients in need-based and self-reliant care.

Inclusion criteria:

We will consider both published and unpublished studies and reports exploring the process of implementing the Buurtzorg community nursing model for older adults’ care internationally.

Methods:

We will implement a three-step search strategy to locate both published and unpublished primary studies, theses, dissertations, book chapters, and text and opinion reports using the following databases: MEDLINE (PubMed), LILACS (BVS Portal), COCHRANE (Cochrane Library), CINAHL (EBSCO), Web of Science (Clarivate Analytics), Google Scholar (Google), Embase and Scopus (Elsevier), ProQuest Dissertations and Theses Global (ProQuest), and the official Buurtzorg website (https://www.buurtzorg.com/). We will present the search strategy in a PRISMA flow diagram. Data will be extracted using Excel spreadsheets (Redmond, Washington, USA) and then analyzed narratively. Extracted data will be quantitatively pooled in tables using descriptive statistics to synthesize the characteristics of the reports and sample, followed by a qualitative summary of how the Buurtzorg model has been used, and what the challenges and facilitators of implementing this care model are.
Experiences of residents of long-term-care homes with the use of socially assistive technologies and the effectiveness of these technologies: a mixed methods systematic review protocol
Authors: Macdonald Marilyn , Weeks Lori , Moody Elaine , Martin-Misener Ruth , Iduye Damilola , States Chelsa , Ignaczak Melissa , Delahunty-Pike Alannah , Caruso Julie , Simm Janet , Rothfus Melissa
Published: September 2022

Objective:

The objective of this review is to explore the experiences of residents of long-term-care homes using socially assistive technologies and the effectiveness of these technologies in relation to depression, loneliness, and social interaction.

Introduction:

Research related to the experiences of residents of long-term-care homes with socially assistive technologies, and their effectiveness, is limited. This population of older adults is projected to steeply increase in the future, as will the need for services, such as long-term care. Older adults (≥65 years) in long-term care are at increased risk of depression, loneliness, and social isolation. Therefore, there is a need to explore the experiences of long-term-care residents with the use of socially assistive technologies and to determine the effectiveness of these technologies in relation to depression, loneliness, and social interaction.

Inclusion criteria:

This review will include studies about the experiences of older adults in long-term care using socially assistive technologies, and the effectiveness of these technologies. Older adults are defined as people 65 years of age and above. We will consider human-to-human socially assistive technologies, such as computers, smart phones, tablets, and associated applications. We will review quantitative, qualitative, and mixed methods studies.

Methods:

A JBI mixed methods convergent segregated approach will be used. Select databases and gray literature will be searched for published and unpublished studies, with no date or language limits. Titles, abstracts, and full texts of included studies will be screened by at least two reviewers, and undergo quality appraisal, data extraction, and synthesis of quantitative and qualitative data followed by integration of the two types of evidence.

Systematic review registration number:

PROSPERO CRD42021279015
Factors influencing self-perceived functioning after volar locking plate fixation of distal radius fractures: a scoping review protocol
Authors: Boel Susanne , Vinther Anders , Hansen Alice Ørts , Juhl Carsten Bogh , Landgren Marcus , Kristensen Hanne Kaae
Published: September 2022

Objective:

The objective of this review is to give an overview of the demographic, peri-, and postoperative factors that have been assessed for influence on self-perceived functioning at least 3 months after volar locking plate fixation of a distal radius fracture.

Introduction:

Most patients treated with a volar locking plate for a distal radius fracture recover within months after surgery; however, a subgroup of patients experience complications and slow recovery. A variety of demographic, peri-, and postoperative factors may influence self-perceived functioning. To facilitate functioning after surgery, supervised rehabilitation can be offered by a hand therapist. In the decision-making process about which patients to offer supervised rehabilitation, demographic, peri-, and postoperative factors may provide additional information, but no updated overview of explored factors has been found.

Inclusion criteria:

This review will consider all studies reporting on peri- and postoperative factors identified within 6 weeks after surgery, or demographic factors assessed for influence on self-perceived functioning experienced by patients at least 3 months after volar locking plate fixation of distal radius fractures.

Methods:

MEDLINE, CINAHL, Embase, Cochrane Library, PsycINFO, SPORTSdiscus, and Web of Science will be searched for eligible studies. The review will consider peer-reviewed studies published after 2005 in English and Scandinavian languages. Two reviewers will independently perform study selection and data extraction. Following a content analysis of each identified factor, the factors will be mapped to the International Classification of Functioning, Disability and Health (ICF) components by using the ICF linking rules. An overview will be depicted graphically or in tabular format for different timepoints based on assessment of the self-perceived functioning.
Effectiveness of prophylactic tranexamic acid versus placebo or no intervention for reducing blood loss in healthy patients undergoing orthognathic surgery: a systematic review protocol
Authors: Baghaie Hooman , Shukla Khilan , Stone Jennifer , Breik Omar , Munn Zachary
Published: September 2022

Objective:

The objective of this review is to evaluate the effectiveness of perioperative prophylactic tranexamic acid for reducing blood loss in orthognathic surgery in healthy patients.

Introduction:

Orthognathic surgery can cause significant hemorrhage, which requires postoperative blood transfusions. The most widely studied pharmaceutical adjunct for reducing blood loss is tranexamic acid, a synthetic amino acid that reversibly inhibits plasminogen activation. It is widely used and validated in other surgical procedures to limit blood loss; however, it is not a gold standard in orthognathic surgery.

Inclusion criteria:

We will include clinical trials comparing tranexamic acid to appropriate controls. The primary outcomes are intraoperative blood loss, change in hematocrit/hemoglobin level, and need for blood transfusion. Secondary outcomes include operating time, length of hospital stay, and adverse reactions. Studies of patients with pre-existing coagulopathies and those undergoing only minor orthognathic surgery (eg, genioplasty) will be excluded.

Methods:

We will search 3 electronic databases (PubMed, Embase, and Cochrane Library) from database inception. Titles, abstracts, and full-text papers will be assessed against the inclusion criteria by 2 independent reviewers. Risk of bias will be assessed using the Cochrane Risk of Bias 2.0 tool. Data will be extracted by 2 independent reviewers. Meta-analysis will be conducted for all outcomes where appropriate, with weighted mean differences used for intraoperative blood loss, changes in hematocrit/hemoglobin levels, operation time, and length of stay; and risk ratio for transfusion rates and adverse outcomes. Certainty of the evidence will be presented using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.

Systematic review registration number:

PROSPERO CRD42022314403
Ketogenic diet‐induced weight loss occurs independent of housing temperature and is followed by hyperphagia and weight regain after cessation in mice
Authors: Weber Alyssa , Medak Kyle D. , Townsend Logan K. , Wright David C.
Published: September 2022

Ketogenic diets (KDs) are a popular tool used for weight management. Studies in mice have demonstrated that KDs reduce food intake, increase energy expenditure and cause weight loss. These studies were completed at room temperature, a condition below the animal's thermal neutral zone which induces thermal stress. As energy intake and expenditure are sensitive to environmental temperature it is not clear if a KD would exert the same beneficial effects under thermal neutral conditions. Adherence to restrictive diets is poor and consequently it is important to examine the effects, and underlying mechanisms, of cycling from a ketogenic to an obesogenic diet. The purpose of the current study was to determine if housing temperature impacted the effects of a KD in obese mice and to determine if the mechanisms driving KD‐induced weight loss reverse when mice are switched to an obesogenic high fat diet. We demonstrate that KD‐induced reductions in food intake, increases in energy expenditure, weight loss and improvements in glucose homeostasis are not dependent upon housing temperature. KD‐induced weight loss seems to be largely explained by reductions in caloric intake while cycling mice back to an obesogenic diet following a period of KD feeding leads to hyperphagia‐induced weight gain. Collectively, our results suggest that prior findings with mice fed a KD at room temperature are likely not an artifact of how mice were housed and that initial changes in weight when transitioning from an obesogenic to a ketogenic diet or back are largely dependent on food intake.

image

Key points

Ketogenic diets reduce food intake, increase energy expenditure and cause weight loss in rodents

Prior preclinical studies have been completed at room temperature, a condition which induces thermal stress and limits clinical translatability

Here it is demonstrated that ketogenic diet‐induced reductions in food intake, increases in energy expenditure, weight loss and improvements in glucose homeostasis are similar in mice housed at room temperature or thermal neutrality

Ketogenic diet‐induced reductions in food intake appear to explain a large degree of weight loss. Similarly, switching mice from a ketogenic to an obesogenic diet leads to hyperphagia‐mediated weight gain
A Constitutive Model to Characterize In Vivo Human Palmar Tissue
Authors: Shojaeizadeh Maedeh , Spartacus Victoria , Sparrey Carolyn J.
Published: September 2022

In vivo characteristics of palmar soft tissue can be used to improve the accuracy of human models to explore and simulate a range of contact scenarios. Tissue characteristics can help to assess injury prevention strategies and designing technologies that depend on quantified physical contacts such as prosthetics, wearables, and assistive devices. In this study, a simplified quasi-linear viscoelastic (QLV) model was developed to quantify large deformation, in vivo soft tissue relaxation characteristics of the palm. We conducted relaxation tests on 11 young adults (6 males, 5 females, 18 < age < 30, mean age: 25 ± 4 yr) and 9 older adults (6 males, 3 females, age > 50, mean age: 61.5 ± 11.5 yr) using a 3 mm indenter to a depth of 50% of each participant's soft tissue thickness. The relaxation parameters of the QLV model were found to differ with age and sex, emphasizing the importance of using targeted material models to represent palmar soft tissue mechanics. Older adults showed on average 2.3-fold longer relaxation time constant compared to younger adults. It took 1.2-fold longer for young males to reach equilibrium than for young females; however, young females had a higher level of relaxation (36%) than young males (33%). Differences in specific QLV model parameters, P1, P2, and α were also found between age and sex groups. QLV characteristics differentiated by age and sex, add biofidelity to computational models which can provide a better representation of the diversity of tissue properties in the population.
Learning behavior of Neoseiulus californicus (Acari: Phytoseiidae) can help in adapting from feeding on alternative prey to target prey
Authors: Zhu Jia-Yun , Liu Jing , Qin Li , Xiao Feng , Liu Jian-Feng , Xiao Rong
Published: September 2022

Neoseiulus californicus (Acari: Phytoseiidae) is a commercialized predatory mite that is used as a biological control agent against Tetranychus urticae (Acari: Tetranychidae). Long-term feeding on alternative prey could impact the predatory capacity of N. californicus. Although most studies on the learning behavior of predatory mites have indicated that learning behavior could help them adapt from feeding on thrips (alternative prey) to spider mites (target prey), the role of learning behavior in adapting from feeding on astigmatid mites to spider mites has not been studied thus far. Therefore, this study explored the learning behavior of N. californicus in adapting from feeding on alternative prey (Oulenziella bakeri [Acari: Winterschmidtiidae]) to target mites (T. urticae). The attack latencies, prey preferences, and functional responses of female N. californicus were compared between two strains, N. californicus fed on T. urticae (TU) or O. bakeri (OB), and a learning behavior (LB) treatment. The results showed that the attack latency of OB strain was significantly longer than those of TU strain and LB treatment; OB strain did not show obvious prey preference between protonymphs of T. urticae and O. bakeri; and the functional response among TU, OB, and LB-treated strains were not significantly different. Our results demonstrated that long-term feeding on alternative prey had little effect on the predatory ability of N. californicus. To a certain extent, learning behavior can help N. californicus shift from feeding on alternative prey to target prey. Therefore, in the long run, it is reasonable to rear N. californicus on O. bakeri.
Super-resolution wearable electrotactile rendering system
Authors: Lin Weikang , Zhang Dongsheng , Lee Wang Wei , Li Xuelong , Hong Ying , Pan Qiqi , Zhang Ruirui , Peng Guoxiang , Tan Hong Z. , Zhang Zhengyou , Wei Lei , Yang Zhengbao
Published: September 2022

The human somatosensory system is capable of extracting features with millimeter-scale spatial resolution and submillisecond temporal precision. Current technologies that can render tactile stimuli with such high definition are neither portable nor easily accessible. Here, we present a wearable electrotactile rendering system that elicits tactile stimuli with both high spatial resolution (76 dots/cm
2
) and rapid refresh rates (4 kHz), because of a previously unexplored current-steering super-resolution stimulation technique. For user safety, we present a high-frequency modulation method to reduce the stimulation voltage to as low as 13 V. The utility of our high spatiotemporal tactile rendering system is highlighted in applications such as braille display, virtual reality shopping, and digital virtual experiences. Furthermore, we integrate our setup with tactile sensors to transmit fine tactile features through thick gloves used by firefighters, allowing tiny objects to be localized based on tactile sensing alone.
Evolving symbolic density functionals
Authors: Ma He , Narayanaswamy Arunachalam , Riley Patrick , Li Li
Published: September 2022

Systematic development of accurate density functionals has been a decades-long challenge for scientists. Despite emerging applications of machine learning (ML) in approximating functionals, the resulting ML functionals usually contain more than tens of thousands of parameters, leading to a huge gap in the formulation with the conventional human-designed symbolic functionals. We propose a new framework, Symbolic Functional Evolutionary Search (SyFES), that automatically constructs accurate functionals in the symbolic form, which is more explainable to humans, cheaper to evaluate, and easier to integrate to existing codes than other ML functionals. We first show that, without prior knowledge, SyFES reconstructed a known functional from scratch. We then demonstrate that evolving from an existing functional ωB97M-V, SyFES found a new functional, GAS22 (Google Accelerated Science 22), that performs better for most of the molecular types in the test set of Main Group Chemistry Database (MGCDB84). Our framework opens a new direction in leveraging computing power for the systematic development of symbolic density functionals.
Supplemental Material: Cenozoic kinematic histories of the Tidding and Lohit thrusts in the northern Indo-Burma Ranges: Implications for crustal thickening and exhumation of Gangdese lower arc crust along the Indus-Yarlung suture zone
Authors: Haproff Peter J. , al. et
Published: September 2022

Methodological details, additional figures, and data tables.
Supplemental Material: Emplacement dynamics of a crystal-rich, highly viscous trachytic flow of the Sancy stratovolcano, France
Authors: Prival Jean-Marie , Harris Andrew J.L. , al. et
Published: September 2022

Full list of samples with geographic coordinates and orientations.
Impact of targeted diabetic retinopathy training for graders in Vietnam and the implications for future diabetic retinopathy screening programmes: a diagnostic test accuracy study
Authors: Curran Katie , Congdon Nathan , Hoang Tung Thanh , Lohfeld Lynne , Nguyen Van Thu , Nguyen Hue Thi , Nguyen Quan Nhu , Dardis Catherine , Virgili Gianni , Piyasena Prabhath , Tran Huong , Salongcay Recivall Pascual , Tung Mai Quoc , Peto Tunde
Published: September 2022

Objectives

To compare the accuracy of trained level 1 diabetic retinopathy (DR) graders (nurses, endocrinologists and one general practitioner), level 2 graders (midlevel ophthalmologists) and level 3 graders (senior ophthalmologists) in Vietnam against a reference standard from the UK and assess the impact of supplementary targeted grader training.

Design

Diagnostic test accuracy study.

Setting

Secondary care hospitals in Southern Vietnam.

Participants

DR training was delivered to Vietnamese graders in February 2018 by National Health Service (NHS) UK graders. Two-field retinal images (412 patient images) were graded by 14 trained graders in Vietnam between August and October 2018 and then regraded retrospectively by an NHS-certified reference standard UK optometrist (phase I). Further DR training based on phase I results was delivered to graders in November 2019. After training, a randomised subset of images from January to October 2020 (115 patient images) was graded by six of the original cohort (phase II). The reference grader regraded all images from phase I and II retrospectively in masked fashion.

Primary and secondary outcome measures

Sensitivity was calculated at the two different time points, and χ2was used to test significance.

Results

In phase I, the sensitivity for detecting any DR for all grader groups in Vietnam was low (41.8–42.2%) and improved in phase II after additional training was delivered (51.3–87.2%). The greatest improvement was seen among level 1 graders (p<0.001), and the lowest improvement was observed among level 3 graders (p=0.326). There was a statistically significant improvement in sensitivity for detecting referable DR and referable diabetic macular oedema between all grader levels. The post-training values ranged from 40.0 to 61.5% (including ungradable images) and 55.6%–90.0% (excluding ungradable images).

Conclusions

This study demonstrates that targeted training interventions can improve accuracy of DR grading. These findings have important implications for improving service delivery in DR screening programmes in low-resource settings.
Systematic review of the effectiveness of the health inequalities strategy in England between 1999 and 2010
Authors: Holdroyd Ian , Vodden Alice , Srinivasan Akash , Kuhn Isla , Bambra Clare , Ford John Alexander
Published: September 2022

Objectives

The purpose of this systematic review is to explore the effectiveness of the National Health Inequality Strategy, which was conducted in England between 1999 and 2010.

Design

Three databases (Ovid Medline, Embase and PsycINFO) and grey literature were searched for articles published that reported on changes in inequalities in health outcomes in England over the implementation period. Articles published between January 1999 and November 2021 were included. Title and abstracts were screened according to an eligibility criteria. Data were extracted from eligible studies, and risk of bias was assessed using the Risk of Bias in Non-randomized Studies of Interventions tool.

Results

The search strategy identified 10 311 unique studies, which were screened. 42 were reviewed in full text and 11 were included in the final review. Six studies contained data on inequalities of life expectancy or mortality, four on disease-specific mortality, three on infant mortality and three on morbidities. Early government reports suggested that inequalities in life expectancy and infant mortality had increased. However, later publications using more accurate data and more appropriate measures found that absolute and relative inequalities had decreased throughout the strategy period for both measures. Three of four studies found a narrowing of inequalities in all-cause mortality. Absolute inequalities in mortality due to cancer and cardiovascular disease decreased, but relative inequalities increased. There was a lack of change, or widening of inequalities in mental health, self-reported health, health-related quality of life and long-term conditions.

Conclusions

With respect to its aims, the strategy was broadly successful. Policymakers should take courage that progress on health inequalities is achievable with long-term, multiagency, cross-government action.

Trial registration number

This study was registered in PROSPERO (CRD42021285770).
Assessment of person-centeredness in healthcare and social support services for women with unintended pregnancy (CarePreg): protocol for a mixed-method study
Authors: Zill Jördis M , Lindig Anja , Reck Lara Maria , Scholl Isabelle , Härter Martin , Hahlweg Pola
Published: September 2022

Introduction

For women with unintended pregnancy, access to high-quality care has been found limited due to social stigma and legal restrictions, especially when seeking abortion. To foster person-centeredness (PC), recognising the experiences and needs of women is the first premise. This study aims to (1) identify relevant dimensions of PC (2) evaluate PC in healthcare and social support services, (3) develop recommendations for further actions in healthcare and social support services for women with unintended pregnancy.

Methods and analysis

We will use a mixed-methods approach. Phase 1: expert workshops with 10–15 healthcare professionals and counsellors and semistructured interviews with 15–20 women with unintended pregnancy will be conducted to assess the relevance of PC dimensions. Phase 2: quantitative assessment of PC dimensions within healthcare and support services will be conducted. We aim to include 600 women with an unintended pregnancy (1) until 24 weeks of pregnancy or (2) who sought abortion within the past 8 weeks, over three measurement points within 12 months. To deepen the results, semistructured interviews will be conducted. Phase 3: a workshop with 10–15 experts and an online survey with 100–150 experts will be used to indicate recommendations. Participants will be gained through relevant care facilities. An ethical advisory board and an advisory board of affected women will be involved throughout the study.

Ethics and dissemination

The study will be carried out in accordance to the latest version of the Helsinki Declaration of the World Medical Association and principles of good scientific practice. The study was approved by the Local Psychological Ethics Committee of the University Medical Center Hamburg-Eppendorf, Germany (LPEK-0260). Written informed consent will be sought prior to study participation. The study results will be disseminated in scientific journals, through collaboration partners and plain language press releases.
Association of bridging therapy utilization with clinical outcomes in patients receiving chimeric antigen receptor (CAR) T-cell therapy
Authors: Johnson P Connor , Jacobson Caron , Yi Alisha , Gaballa Mahmoud R , Horick Nora , Rabideau Dustin J , Lindell Kevin , DePinho Gabriel D , El-Jawahri Areej R , Frigault Matthew J
Published: September 2022

Background

Chimeric antigen receptor (CAR) T-cell therapy recipients may receive bridging therapy while awaiting product manufacturing to control disease. Yet, data are lacking regarding the impact of bridging therapy use on clinical outcomes.

Methods

We conducted a retrospective analysis of 235 patients who received CAR T-cell therapy at two tertiary care centers from February 2016 to December 2019. We abstracted clinical outcomes from review of the electronic health record including (1) overall response; (2) complete response (CR); (3) progression-free survival (PFS); (4) overall survival (OS); and (5) toxicity (cytokine release syndrome (CRS) and neurotoxicity). We assessed the association of bridging therapy use with overall response rate (ORR) and CR rate using multivariable logistic regression and with PFS and OS using multivariable Cox regression controlling for covariates. We analyzed the association of bridging therapy use with CRS and neurotoxicity using Fisher’s exact test.

Results

Patients’ median age was 63.1 years (range: 19–82), and the majority were men (144/235, 61.3%). Most patients received axicabtagene ciloleucel (192/235, 81.7%), and the most common lymphoma subtype was diffuse large B-cell lymphoma or grade 3B follicular lymphoma (107/235, 45.5%). Overall, 39.4% (93/236) received bridging therapy. Bridging therapy regimens included systemic chemotherapy (48/92, 52.2%), corticosteroids (25/92, 27.2%), radiation (9/92, 9.8%), and other systemic therapies (10/92, 10.9%). In multivariable Cox regression, bridging therapy use was associated with OS (HR: 1.97, p=0.004) but not PFS (HR: 1.18, p=0.449). In multivariable logistic regression, bridging therapy use was not associated with ORR (OR: 0.69, p=0.391) or CR rate (OR: 0.96, p=0.901). We did not identify an association of bridging therapy use with grade 3+ CRS (p=0.574) or grade 3+ neurotoxicity (p=0.748).

Conclusions

We identified that bridging therapy use is not associated with differences in ORR, CR rate, or PFS but is associated with worse OS. These data suggest bridging therapy may be a surrogate for additional poor prognostic factors leading to inferior OS and underscore the need for novel bridging therapy regimens to optimize outcomes in this patient population.
Peptide emulsions in incomplete Freund’s adjuvant create effective nurseries promoting egress of systemic CD4+and CD8+T cells for immunotherapy of cancer
Authors: Melssen Marit M , Fisher Caroline T , Slingluff Craig L , Melief Cornelis J M
Published: September 2022

Water-in-oil emulsion incomplete Freund’s adjuvant (IFA) has been used as an adjuvant in preventive and therapeutic vaccines since its development. New generation, highly purified modulations of the adjuvant, Montanide incomplete seppic adjuvant (ISA)-51 and Montanide ISA-720, were developed to reduce toxicity. Montanide adjuvants are generally considered to be safe, with adverse events largely consisting of antigen and adjuvant dose-dependent injection site reactions (ISRs). Peptide vaccines in Montanide ISA-51 or ISA-720 are capable of inducing both high antibody titers and durable effector T cell responses. However, an efficient T cell response depends on the affinity of the peptide to the presenting major histocompatibility complex class I molecule, CD4+T cell help and/or the level of co-stimulation. In fact, in the therapeutic cancer vaccine setting, presence of a CD4+T cell epitope seems crucial to elicit a robust and durable systemic T cell response. Additional inclusion of a Toll-like receptor ligand can further increase the magnitude and durability of the response. Use of extended peptides that need a processing step only accomplished effectively by dendritic cells (DCs) can help to avoid antigen presentation by nucleated cells other than DC. Based on recent clinical trial results, therapeutic peptide-based cancer vaccines using emulsions in adjuvant Montanide ISA-51 can elicit robust antitumor immune responses, provided that sufficient tumor-specific CD4+T cell help is given in addition to CD8+T cell epitopes. Co-treatment with PD-1 T cell checkpoint inhibitor, chemotherapy or other immunomodulatory drugs may address local and systemic immunosuppressive mechanisms, and further enhance efficacy of therapeutic cancer peptide vaccines in IFA and its modern variants. Blinded randomized placebo-controlled trials are critical to definitively prove clinical efficacy. Mineral oil-based adjuvants for preventive vaccines, to tackle spread and severity of infectious disease, induce immune responses, but require more studies to reduce toxicity.
A substandard candle: the low-$$\nu $$ method at few-GeV neutrino energies
Authors: Wilkinson C. , Dolan S. , Pickering L. , Wret C.
Published: September 2022

As accelerator-based neutrino oscillation experiments improve oscillation parameter constraints with more data, control over systematic uncertainties on the incoming neutrino flux and interaction models is increasingly important. The intense beams offered by modern experiments permit a variety of options to constrain the flux using in situ “standard candle” measurements. These standard candles must use very well understood interaction processes to avoid introducing additional interaction model dependence. One option often discussed in this context is the “low-$$\nu $$
ν
” method, which is designed to isolate neutrino interactions where there is low energy-transfer to the nucleus, such that the interaction cross section is expected to be approximately constant as a function of neutrino energy. The shape of the low-energy transfer event sample can then be used to extract the flux shape. Applications of the method at high neutrino energies (many tens of GeV) are well understood. However, the applicability of the method at the lower energies of current and future few-GeV accelerator neutrino experiments remains unclear due to the presence of nuclear and form-factor effects inherent in the interaction models.In this analysis we examine the prospects for improving constraints on the accelerator neutrino fluxes in situ with the low-$$\nu $$
ν
method in an experiment-independent way, using (anti)neutrino interactions on argon and hydrocarbon targets from the GENIE, NEUT, NuWro and GiBUU event generators. We begin by investigating the extent to which deviations from the constant cross-section assumption are dependent on poorly understood aspects of the neutrino interaction model. We then assess whether a low energy-transfer event sample can be confidently identified using experimentally accessible observables. We finally consider how the practicalities of reconstructing the energy spectrum of interacting neutrinos in realistic detectors might further limit the utility of low-$$\nu $$
ν
flux constraints. The results show that flux constraints from the low-$$\nu $$
ν
method would be severely dependent on the interaction model assumptions used in an analysis of neutrinos with energies below 5 GeV, and anti-neutrinos below at least 15 GeV. The spread of model predictions show that a low-$$\nu $$
ν
analysis is unlikely to offer much improvement on typical neutrino flux uncertainties, even with a perfect detector. Notably—running counter to the assumption inherent to the low-$$\nu $$
ν
method—the model-dependence increases with decreasing energy transfer for experiments in the few-GeV region.
Ruppeiner geometry, P–V criticality and interacting microstructures of black holes in dRGT massive gravity
Authors: Safir T. K. , Rizwan C. L. Ahmed , Vaid Deepak
Published: September 2022

We probe the microstructure of the dRGT massive black hole in an anti-de Sitter background. The calculations are performed in an extended phase space with pressure and volume taken as fluctuation variables. We analyze the microstructure by exploiting the Ruppeiner geometry, where the thermodynamic curvature scalar is constructed via adiabatic compressibility. The nature of the curvature scalar along the coexistence line of small black hole (SBH) and large black hole (LBH) is investigated. In the microscopic interaction, we observe that the SBH phase behaves as an anyonic gas and the LBH phase is analogous to a boson gas. Further, we study the effect of graviton mass on the underlying microstructure of the black hole.
Lovelock black holes with double-logarithmic electrodynamics source
Authors: Ali Askar
Published: September 2022

This work examines the magnetized black holes of Lovelock gravity in the presence of double-logarithmic electrodynamics. In this context, the Lovelock polynomial is found and the accompanying thermodynamic quantities, such as mass, entropy, Hawking temperature, and heat capacity, are determined. This new model of nonlinear electrodynamics is used to calculate the black hole solutions of Einstein, Gauss–Bonnet and third-order Lovelock gravities as well. The impacts of the double-logarithmic electromagnetic field on the black hole thermodynamics in these particular theories are examined and the regions of horizon radius that correspond to the local thermodynamic stability are highlighted.
Finite representation of commutator sequences
Authors: Aichinger Erhard , Mudrinski Nebojša
Published: September 2022

Several structural properties of an algebraic structure can be seen from the higher commutators of its congruences. Even on a finite algebra, the sequence of higher commutator operations is an infinite object. In this paper, we exhibit finite representations of this sequence for finite algebras from congruence modular varieties.
TOWARDS A MEASURE OF HARMONIC COMPLEXITY IN WESTERN CLASSICAL MUSIC
Authors: BUONGIORNO NARDELLI MARCO , CULBRETH GARLAND , FUENTES MIGUEL
Published: September 2022

We recently introduced the concept of dynamical score network to represent the harmonic progressions in any composition. Through a process of chord slicing, we obtain a representation of the score as a complex network, where every chord is a node and each progression (voice leading) links successive chords. In this paper, we use this representation to extract quantitative information about harmonic complexity from the analysis of the topology of these networks using state-of-the-art statistical mechanics techniques. Since complex networks support the communication of information by encoding the structure of allowed messages, we can quantify the information associated with locating specific addresses through the measure of the entropy of such network. In doing so, we then characterize properties of network topology, such as the degree distribution of a graph or the shortest paths between couples of nodes. Here, we report on two different evaluations of network entropy, diffusion entropy analysis (DEA) and the Kullback–Leibler divergence applied to the conditional degree matrix, and the measurements of complexity they provide, when applied to an extensive corpus of scores spanning 500 years of western classical music. Although the analysis is limited in scope, our results already provide quantitative evidence of an increase of such measures of harmonic complexity over the corpora we have analyzed.
Translation and modulation invariant Banach spaces of tempered distributions satisfy the metric approximation property
Authors: Feichtinger Hans G.
Published: September 2022

In this paper, we establish the validity of the so-called Bounded Approximation Property (BAP) for a comprehensive class of translation and modulation invariant Banach spaces (B, ∥ · ∥B) of tempered distributions on the Euclidean space [Formula: see text]. In fact, such spaces have a double module structure, over some Beurling algebra with respect to convolution, and with respect to pointwise multiplication over some Fourier Beurling algebra. Combining this double module structure with functional analytic arguments which describe the approximation of convolution operators by discrete convolutions we are able to verify the BAP, in fact, for most cases even the Metric Approximation Property (MAP) for such Banach space. The family of spaces under consideration is very rich and contains virtually all the classical function spaces relevant for mathematical analysis, as long as the Schwartz space [Formula: see text] is dense in (B, ∥ · ∥B). In particular, all the reflexive spaces in this family are included. Moreover, this family of Banach spaces is closed with respect to intersections, sums and various interpolation methods.
Bianchi type-V transitioning model in Brans–Dicke theory with observational constraints
Authors: Bhardwaj Vinod Kumar , Dixit Archana , Pradhan Anirudh
Published: September 2022

In this paper, we have examined the viability of the Bianchi type-V universe in Brans–Dicke (BD) theory of gravitation. We have discussed the interacting and non-interacting scenarios between dark matter (DM) and dark energy (DE) of the derived universe within the framework of BD theory. CCA technique has been applied to constrain the model parameters using 46 values of observational Hubble data (OHD), Pantheon data (the latest compilation of SNIa with 40 binned in the redshift range [Formula: see text] and their combined datasets. We establish an exact solution of the field equations to derive the dynamics of the derived universe and the obtained results are found to agree with the observations. We also noted a distinctive change in the sign of the deceleration parameter from positive to negative, as well as the presence of a transition red-shift exists. Using various observational data points, the evolution trajectories for [Formula: see text] diagnostic planes are shown to understand the geometrical behavior of the Bianchi-V model. Some physical properties of the universe are also discussed. It is also worth noting that the conclusions of the cosmological parameter are consistent with modern observational data.
On the bundle of null cones
Authors: Bruce Andrew James
Published: September 2022

We examine the bundle structure of the field of nowhere vanishing null vector fields on a (time-oriented) Lorentzian manifold. Sections of what we refer to as the null tangent are by definition nowhere vanishing null vector fields. It is shown that the set of nowhere vanishing null vector fields comes equipped with a para-associative ternary partial product. Moreover, the null tangent bundle is an example of a non-polynomial graded bundle.
Geometry of a surface in Riemannian 3-manifold corresponding to a smooth autonomous dynamical system
Authors: Bayrakdar Tuna
Published: September 2022

In this work, we identify a smooth autonomous dynamical on a two-dimensional manifold with an exterior differential system [Formula: see text], where [Formula: see text] is a three-dimensional Riemannian manifold and [Formula: see text] is the differential ideal generated by the contact forms on [Formula: see text]. We investigate the intrinsic and the extrinsic geometry of a surface in [Formula: see text] and show that for a particular dynamical system [Formula: see text] admits a totally geodesic surface determined by a constant value of a coordinate function. We also exhibit that such a surface may define intrinsically nonflat minimal surface which is not necessarily totally geodesic.
Identities of the Jones monoid 𝒥5
Authors: Shahzamanian M. H.
Published: September 2022

Jones monoids [Formula: see text], for [Formula: see text], is a family of monoids relevant in knot theory. The purpose of this paper is to characterize the identities satisfied by the Jones monoid [Formula: see text].
Microwave Attenuation Studies of Polypyrrole-SWCNT Nanocomposite Films for Improved EMI Shielding
Authors: Raju P. , Kanaka Durga M. , Udaya Kumar S. , Neeraja Rani G.
Published: September 2022

In the process of finding stable, lightweight, broadband, cost-effective and improved electromagnetic interference (EMI) shielding material, electromagnetic wave attenuation properties of polypyrrole (PPy)—single-walled carbon nanotube (SWCNT) nanocomposite hybrid films were investigated in X-band region (8.2–12.4 GHz) and reported in the present work. The incorporation of SWCNT as a nanofiller in polymer matrix exhibits enhanced EMI shielding performance as compared to pure polymer films. The substantial values of dielectric loss with good impedance matching contribute to improvement in EMI shielding performance. It is found that with an increase of SWCNT loading in polymer matrix from 0 wt% to 5 wt%, nanocomposite films display a gradual increase in AC conductivity and total shielding effectiveness. The maximum total shielding effectiveness of 32.10 dB and minimum reflection loss of −45.54 dB with a wide bandwidth of 3.1 GHz, were obtained for 5 wt% CNT loading. The present results revealed that the prepared nanocomposite films are appropriate materials for lightweight, broadband EMI shields for radar and stealth applications.
Numerical Analysis of Flow-Induced Vibration of Heat Exchanger Tube Bundles Based on Fluid-Structure Coupling Dynamics
Authors: Chen Lei , Zhang Hongxin , Huang Song , Wang Bo , Zhang Chuanliang
Published: September 2022

According to the needs generated by the industry, there is an urgent need to investigate the flow vibration response law of the elastic tube bundle of heat exchangers subjected to the coupling effect of shell and tube domain at different inlet flow velocities. In this paper, based on the continuity equation, momentum equation, turbulence model, and dynamic grid technology, the vibration response of the elastic tube bundle under the mutual induction of shell and tube fluids is studied by using pressure-velocity solver and two-way fluid-structure coupling (FSC) method. The results show that the monitoring points on the same connection block have the same vibration frequency, while the vibration amplitude is different. Monitoring point A is the most deformed by the impact of fluid in the shell and tube domain. When the inlet velocity(

v

shell

=

v

tube

=
0.15

, 0.4, 0.5 m/s) of shell and tube is low, the amplitude of tube bundle vibration in the

Y

direction is greater than that in

X

and

Z

direction, and the tube bundle produces periodic vibration in the vertical direction. The vibration equilibrium position of the tube bundle along the shell flow direction gradually moves up with the increase of the inlet velocity. The amplitude in the

Y

-direction of the elastic bundle decreases with the increase of shell-side and tube-side velocity. The relationship between the vibration amplitude in the

Y

direction and the entrance velocity is a linear function.
Internal Synchronization Using Adaptive Control
Authors: Shahzad Mohammad , Raziuddin Mohammed , Naheed Mohammed
Published: September 2022

This paper mainly deals on the issue of a chaotic synchronization of a master and slave systems. It is generally the requirement of the synchronization that someone needs at least one to one master and slave systems. In the current study, the authors introduce the concept of a synchronization in which there is no need of slave/response system externally. Furthermore, the synchronization has been demonstrated here within a system among the subsystems of different orders. In addition, adaptive control is chosen for the synchronization among various combinations in multiswitching manner. For demonstration purpose, Lorenz Six Dimensional Hyper Chaotic System (L6DHCS) is chosen. There are three different kinds of possible switches presented by the authors formed within the considered system. The numerical simulations are carried out to validate the effectiveness of the analytical technique using Mathematica.
Hydrogel-Crosslinked Microneedles Based on Microwave-Assisted Drying Method
Authors: Chen Dongyu , Zhang Yu , Chen Xiaoke , He Qiyao , Wu Tianwei , Cao Xiaoping , Liu Jing , You Xueqiu
Published: September 2022

We present a method and several applications for the synthesis of hydrogel-crosslinked microneedle arrays utilizing microwave-assisted drying, ensuring a significant reduction in reaction preparation time while maintaining quality. We demonstrate the feasibility of drying hydrogels using microwaves and thus extend to crosslinked microneedle fabrication. Crosslinking was performed using 1,4-butanediol diglycidyl ether (BDDE) as a crosslinking agent. Infrared spectra of the microneedle arrays were measured with attenuated total reflection-Fourier transform infrared (ATR-FTIR). The surface morphology of the microneedle arrays was observed with scanning electron microscopy (SEM). The microneedle arrays were evaluated in terms of mechanical strength, swelling kinetics, rheological properties, degradation rate, and glucose iontophoresis. The results show that this method can shorten the reaction preparation time by 5 hours, and the prepared crosslinked microneedle array has better crosslinking efficiency, swelling effect, and greater mechanical strength than traditional methods.
Application and Analysis of Improved Fuzzy Comprehensive Evaluation Method in Goodwill Evaluation and Intangible Asset Management
Authors: Xu Mengyue
Published: September 2022

In order to improve the effect of goodwill evaluation and intangible asset management, this paper combines the improved fuzzy comprehensive evaluation method to construct an intelligent algorithm. In order to consider the many influencing factors of intangible asset prices and their own influence, this experiment adopts the ARDL model for analysis. Based on the traditional LSTM model, this paper innovatively introduces sparse principal component analysis for feature dimensionality reduction and, on the other hand, adds a convolutional neural network to the model, which is suitable for feature extraction. In addition, this paper constructs a goodwill evaluation and intangible asset management model based on the improved fuzzy comprehensive evaluation method. The research shows that the improved fuzzy comprehensive evaluation method proposed in this paper has a very good application effect in goodwill evaluation and intangible asset management.