bluuebunny/crossref_metadata_2025 huggingface dataset:
The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure
Authors: Brown Susie L. , Kendrick Samantha
Published: January 2021

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-motif. When within promoter regions, the i-motif has the potential to act as a molecular switch for controlling gene expression. However, i-motif structures in genomic areas of repetitive nucleotide sequences may play a role in facilitating or hindering expansion of these DNA elements. Despite research on the i-motif trailing behind the complementary G-quadruplex structure, recent discoveries including the identification of a specific i-motif antibody are pushing this field forward. This perspective reviews initial and current work characterizing the i-motif and providing insight into the biological function of this DNA structure, with a focus on how the i-motif can serve as a molecular target for developing new therapeutic approaches to modulate gene expression and extension of repetitive DNA.
Understanding Host Immunity and the Gut Microbiota Inspires the New Development of Vaccines and Adjuvants
Authors: Yakabe Kyosuke , Uchiyama Jun , Akiyama Masahiro , Kim Yun-Gi
Published: January 2021

Vaccinations improve the mortality and morbidity rates associated with several infections through the generation of antigen-specific immune responses. Adjuvants are often used together with vaccines to improve immunogenicity. However, the immune responses induced by most on-going vaccines and adjuvants approved for human use vary in individuals; this is a limitation that must be overcome to improve vaccine efficacy. Several reports have indicated that the symbiotic bacteria, particularly the gut microbiota, impact vaccine-mediated antigen-specific immune responses and promote the induction of nonspecific responses via the “training” of innate immune cells. Therefore, the interaction between gut microbiota and innate immune cells should be considered to ensure the optimal immunogenicity of vaccines and adjuvants. In this review, we first introduce the current knowledge on the immunological mechanisms of vaccines and adjuvants. Subsequently, we discuss how the gut microbiota influences immunity and highlight the relationship between gut microbes and trained innate immunity, vaccines, and adjuvants. Understanding these complex interactions will provide insights into novel vaccine approaches centered on the gut microbiota.
Assessment of Antimicrobic, Antivirotic and Cytotoxic Potential of Alginate Beads Cross-Linked by Bivalent Ions for Vaginal Administration
Authors: Pavelková Miroslava , Vysloužil Jakub , Kubová Kateřina , Pavloková Sylvie , Molinková Dobromila , Celer Vladimír , Pechová Alena , Mašek Josef , Vetchý David
Published: January 2021

Antimicrobial agent abuse poses a serious threat for future pharmacotherapy, including vaginal administration. The solution can be found in simple polymeric systems with inherent antimicrobial properties without the need to incorporate drugs, for instance alginate beads cross-linked by bivalent ions. The main goal of the presented study was to provide improvement on the well-documented cytotoxicity of Cu2+ cross-linked alginate. Alginate beads were prepared by external ionotropic gelation by cross-linking with Cu2+, Ca2+ and Zn2+ ions, separately and in mixtures. Morphological properties, swelling capacity, ion release and efficacy against the most common vaginal pathogens (C. albicans, E. coli, E. faecalis and virus strain—human herpesvirus type 1) were evaluated. The prepared particles (particle size 1455.68 ± 18.71–1756.31 ± 16.58 µm) had very good sphericity (0.86 ± 0.04–0.97 ± 0.06). In mixture samples, Cu2+ hampered second ion loading, and was also released incompletely (18.75–44.8%) compared to the single ion Cu2+ sample (71.4%). Efficacy against the selected pathogens was confirmed in almost all samples. Although anticipating otherwise, ion mixture samples did not show betterment over a Cu2+ cross-linked sample in cytotoxicity–pathogen efficacy relation. However, the desired improvement was found in a single ion Zn2+ sample whose minimal inhibition concentrations against the pathogens (0.6–6.12 mM) were close to, or in the same mathematical order as, its toxic concentration of 50 (1.891 mM). In summary, these findings combined with alginate’s biocompatibility and biodegradability give the combination solid potential in antimicrobial use.
Strategies to Get Drugs across Bladder Penetrating Barriers for Improving Bladder Cancer Therapy
Authors: Wang Shupeng , Jin Shaohua , Shu Qinghai , Wu Song
Published: January 2021

Bladder cancer is a significant public health concern and social burden due to its high recurrence risk. Intravesical drug instillation is the primary therapy for bladder cancer to prevent recurrence. However, the intravesical drug therapeutic effect is limited by bladder penetrating barriers. The inadequate intravesical treatment might cause the low drug concentration in lesions, resulting in a high recurrence/progression rate of bladder cancer. Many strategies to get drugs across bladder penetrating barriers have been developed to improve intravesical treatment, including physical and chemical methods. This review summarizes the classical and updated literature and presents insights into great therapeutic potential strategies to overcome bladder penetrating barriers for improving the intravesical treatment of bladder cancer.
Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans
Authors: Okonogi Siriporn , Phumat Pimpak , Khongkhunthian Sakornrat , Chaijareenont Pisaisit , Rades Thomas , Müllertz Anette
Published: January 2021

Clinical use of 4-Allylpyrocatechol (APC), a potential antifungal agent from Piper betle, is limited because of its low water solubility. The current study explores the development of the self-nanoemulsifying drug delivery system (SNEDDS) containing APC (APC-SNEDDS) to enhance APC solubility. Results demonstrated that excipient type and concentration played an important role in the solubility of APC in the obtained SNEEDS. SNEDDS, comprising 20% Miglyol 812N, 30% Maisine 35-1, 40% Kolliphor RH40, and 10% absolute ethanol, provided the highest loading capacity and significantly increased water solubility of APC. Oil-in-water nanoemulsions (NE) with droplet sizes of less than 40 nm and a narrow size distribution were obtained after dispersing this APC-SNEDDS in water. The droplets had a negative zeta potential between −10 and −20 mV. The release kinetics of APC from APC-SNEDDS followed the Higuchi model. The NE containing 1.6 mg APC/mL had effective activity against Candida albicans with dose-dependent killing kinetics and was nontoxic to normal cells. The antifungal potential was similar to that of 1 mg nystatin/mL. These findings suggest that APC-SNEDDS are a useful system to enhance the apparent water solubility of APC and are a promising system for clinical treatment of oral infection caused by C. albicans.
Controlled Release Fertilizers: A Review on Coating Materials and Mechanism of Release
Authors: Lawrencia Dora , Wong See Kiat , Low Darren Yi Sern , Goh Bey Hing , Goh Joo Kheng , Ruktanonchai Uracha Rungsardthong , Soottitantawat Apinan , Lee Learn Han , Tang Siah Ying
Published: January 2021

Rising world population is expected to increase the demand for nitrogen fertilizers to improve crop yield and ensure food security. With existing challenges on low nutrient use efficiency (NUE) of urea and its environmental concerns, controlled release fertilizers (CRFs) have become a potential solution by formulating them to synchronize nutrient release according to the requirement of plants. However, the most significant challenge that persists is the “tailing” effect, which reduces the economic benefits in terms of maximum fertilizer utilization. High materials cost is also a significant obstacle restraining the widespread application of CRF in agriculture. The first part of this review covers issues related to the application of conventional fertilizer and CRFs in general. In the subsequent sections, different raw materials utilized to form CRFs, focusing on inorganic and organic materials and synthetic and natural polymers alongside their physical and chemical preparation methods, are compared. Important factors affecting rate of release, mechanism of release and mathematical modelling approaches to predict nutrient release are also discussed. This review aims to provide a better overview of the developments regarding CRFs in the past ten years, and trends are identified and analyzed to provide an insight for future works in the field of agriculture.
Creation and Validation of a Temperature-Based Phenology Model for Meloidogyne incognita on Common Bean
Authors: Giné Ariadna , Monfort Patricia , Sorribas Francisco Javier
Published: January 2021

The thermal requirements of Meloidogyne incognita on Phaseolus vulgaris in a set of constant soil temperatures were determined and the phenology model was validated at fluctuating soil temperatures. The base temperature (Tb) and the thermal constant (S) from nematode inoculation to females starting to lay eggs were 11.3 °C and 323 accumulated degree days (DD), respectively; Tb = 10.5 °C and S = 147 DD from egg production to emergence of juveniles; and Tb = 11.1 °C and S = 476 DD for life cycle completion. At fluctuating soil temperatures in pots with the minimum lower than Tb and the maximum higher than To (optimal temperature), the DD calculation was carried out by the average daily temperature–Tb (ADTb) and the single sine method over Tb (SSTb) with horizontal, intermediate, and vertical cutoffs. The most accurate were the ADTb and the SSTb with horizontal and intermediate cutoffs (93–106% of the predicted value) but the vertical underestimated the accumulated DD (75–82% of the predicted value). When fluctuating soil temperatures were between Tb and To in a plastic greenhouse, only the ADTb method was used. Life cycle completion was observed around 465 DD (accuracy between 0.95 and 0.99) at four different transplanting dates.
Fungal Infection Induces Anthocyanin Biosynthesis and Changes in DNA Methylation Configuration of Blood Orange [Citrus sinensis L. (Osbeck)]
Authors: Sicilia Angelo , Catara Vittoria , Scialò Emanuele , Lo Piero Angela Roberta
Published: January 2021

The biosynthesis of sweet orange anthocyanins is triggered by several environmental factors such as low temperature. Much less is known about the effect of biotic stress on anthocyanin production in sweet orange, although in other species anthocyanins are often indicated as “defense molecules”. In this work, citrus fruits were inoculated with Penicillium digitatum, the causal agent of green mold, and the amount of anthocyanins and the expression of genes related to their biosynthesis was monitored by RT-real time PCR after 3 and 5 days from inoculation (DPI). Moreover, the status of cytosine methylation of DFR and RUBY promoter regions was investigated by McrBC digestion followed in real-time. Our results highlight that fungal infection induces anthocyanin production by activating the expression of several genes in the biosynthetic pathway. The induction of gene expression is accompanied by maintenance of high levels of methylation at the DFR and RUBY promoters in the inoculated fruits, thus suggesting that DNA methylation is not a repressive mark of anthocyanin related gene expression in sweet orange subjected to biotic stress. Finally, by measuring the expression levels of the Citrus DNA demethylase genes, we found that none of them is up-regulated in response to fungal infection, this result being in accordance with the observed maintenance of high-level DFR and Ruby promoter regions methylation.
Can Foliar Pulverization with CaCl2 and Ca(NO3)2 Trigger Ca Enrichment in Solanum tuberosum L. Tubers?
Authors: Coelho Ana Rita F. , Lidon Fernando C. , Pessoa Cláudia Campos , Marques Ana Coelho , Luís Inês Carmo , Caleiro João , Simões Manuela , Kullberg José , Legoinha Paulo , Brito Maria , Guerra Mauro , Leitão Roberta G. , Galhano Carlos , Scotti-Campos Paula , Semedo José N. , Silva Maria Manuela , Pais Isabel P. , Silva Maria J. , Rodrigues Ana P. , Pessoa Maria F. , Ramalho José C. , Reboredo Fernando H.
Published: January 2021

This study aimed to assess the efficiency of Ca enrichment in tubers of three genotypes of Solanum tuberosum L., through foliar spraying with CaCl2 and Ca(NO3)2 solutions. In this context, soil heterogeneity of three potato-growing fields, as well as the implications of Ca accumulation among tissues and some quality parameters were assessed. Three potato varieties (Agria, Picasso and Rossi) were grown in three production fields and during the life cycle, four pulverizations with calcium chloride (3 and 6 kg ha−1) or calcium nitrate (0.5, 2 and 4 kg ha−1) were applied. For screening the potential phytotoxicity, using Agria as a test system, the potential synthesis of photoassimilates was determined, and it was found that after the 3rd Ca application, leaf gas exchanges were moderately (net photosynthesis), to strongly (stomatal conductance) affected, although without impact on Ca accumulation in tubers. At harvest, the average Ca biofortification index varied between 5–40%, 40–35% and 4.3–13% in Agria, Picasso and Rossi, respectively. Moreover, the equatorial region of the tubers in general showed that Ca accumulation prevailed in the epidermis and, in some cases, in inner areas of the potato tubers. Biofortified tubers with Ca also showed some significant changes in total soluble solids and colorimetric parameters. It is concluded that Ca enrichment of potato tubers through foliar spraying complemented the xylem mass flow of Ca from roots, through phloem redistribution. Both fertilizers showed similar efficiency, but Rossi revealed a lower index of Ca accumulation, eventually due to different metabolic characteristics. Although affected by Ca enrichment, potato tubers maintained a high quality for industrial processing.
Tensile Fatigue Behavior of Polyester and Vinyl Ester Based GFRP Laminates—A Comparative Evaluation
Authors: Ferdous Wahid , Manalo Allan , Yu Peng , Salih Choman , Abousnina Rajab , Heyer Tom , Schubel Peter
Published: January 2021

Fatigue loading is critical to fibre reinforced polymer composites due to their anisotropic and heterogenous nature. This study investigated the tensile fatigue behaviour of polyester and vinyl ester based GFRP laminates to understand the critical aspects of failure mode and fatigue life under cyclic loading. GFRP laminates with two different resin systems (polyester and vinyl ester), two different stress ratios (0.1 and 0.5) and two different environmental conditions (air and water) were investigated at an applied stress of 80%, 60%, and 40% of the ultimate capacity. Based on the investigated parameters (i.e., resin types, stress ratio, environmental conditioning, and maximum applied stress), a fatigue model was proposed. Results show that the resin system plays a great role in fatigue failure mode while the stress ratio and environmental condition significantly affect the tensile fatigue life of GFRP laminates. The types of resin used in GFRP laminates and environmental conditions as input parameters in the proposed fatigue model are a unique contribution.
Glycerol Assisted Pretreatment of Lignocellulose Wheat Straw Materials as a Promising Approach for Fabrication of Sustainable Fibrous Filler for Biocomposites
Authors: Mahmood Hamayoun , Mehmood Saqib , Shakeel Ahmad , Iqbal Tanveer , Kazmi Mohsin Ali , Khurram Abdul Rehman , Moniruzzaman Muhammad
Published: January 2021

Glycerol pretreatment is a promising method for the environmentally-friendly transformation of lignocellulosic materials into sustainable cellulose-rich raw materials (i.e., biopolymer) to fabricate biocomposites. Here, a comparison of aqueous acidified glycerol (AAG) pretreatment of wheat straw (WS) with alkaline, hot water, and dilute acid pretreatments on the thermal and mechanical characteristics of their fabricated composite board is presented. A comparison of total energy expenditure during WS pretreatment with AAG and other solutions was estimated and a comparative influence of AAG processing on lignocellulosic constituents and thermal stability of WS fiber was studied. Results imply that AAG pretreatment was superior in generating cellulose-rich fiber (CRF) as compared to other pretreatments and enhanced the cellulose contents by 90% compared to raw WS fiber. Flexural strength of acidic (40.50 MPa) and hot water treated WS composite (38.71 MPa) was higher compared to the value of 33.57 MPa for untreated composite, but AAG-treated composites exhibited lower values of flexural strength (22.22 MPa) compared to untreated composite samples. Conversely, AAG pretreatment consumed about 56% lesser energy for each kg of WS processed as compared to other pretreatments. These findings recognize that glycerol pretreatment could be a clean and new pretreatment strategy to convert agricultural waste into high-quality CRF as a sustainable raw material source for engineered biocomposite panels.
Functionality of Cellulose Nanofiber as Bio-Based Nucleating Agent and Nano-Reinforcement Material to Enhance Crystallization and Mechanical Properties of Polylactic Acid Nanocomposite
Authors: Shazleen Siti Shazra , Yasim-Anuar Tengku Arisyah Tengku , Ibrahim Nor Azowa , Hassan Mohd Ali , Ariffin Hidayah
Published: January 2021

Polylactic acid (PLA), a potential alternative material for single use plastics, generally portrays a slow crystallization rate during melt-processing. The use of a nanomaterial such as cellulose nanofibers (CNF) may affect the crystallization rate by acting as a nucleating agent. CNF at a certain wt.% has been evidenced as a good reinforcement material for PLA; nevertheless, there is a lack of information on the correlation between the amount of CNF in PLA that promotes its functionality as reinforcement material, and its effect on PLA nucleation for improving the crystallization rate. This work investigated the nucleation effect of PLA incorporated with CNF at different fiber loading (1–6 wt.%) through an isothermal and non-isothermal crystallization kinetics study using differential scanning calorimetry (DSC) analysis. Mechanical properties of the PLA/CNF nanocomposites were also investigated. PLA/CNF3 exhibited the highest crystallization onset temperature and enthalpy among all the PLA/CNF nanocomposites. PLA/CNF3 also had the highest crystallinity of 44.2% with an almost 95% increment compared to neat PLA. The highest crystallization rate of 0.716 min–1 was achieved when PLA/CNF3 was isothermally melt crystallized at 100 °C. The crystallization rate was 65-fold higher as compared to the neat PLA (0.011 min–1). At CNF content higher than 3 wt.%, the crystallization rate decreased, suggesting the occurrence of agglomeration at higher CNF loading as evidenced by the FESEM micrographs. In contrast to the tensile properties, the highest tensile strength and Young’s modulus were recorded by PLA/CNF4 at 76.1 MPa and 3.3 GPa, respectively. These values were, however, not much different compared to PLA/CNF3 (74.1 MPa and 3.3 GPa), suggesting that CNF at 3 wt.% can be used to improve both the crystallization rate and the mechanical properties. Results obtained from this study revealed the dual function of CNF in PLA nanocomposite, namely as nucleating agent and reinforcement material. Being an organic and biodegradable material, CNF has an increased advantage for use in PLA as compared to non-biodegradable material and is foreseen to enhance the potential use of PLA in single use plastics applications.
Morphological, Structural, Thermal, Permeability, and Antimicrobial Activity of PBS and PBS/TPS Films Incorporated with Biomaster-Silver for Food Packaging Application
Authors: Aziman Nurain , Kian Lau Kia , Jawaid Mohammad , Sanny Maimunah , Alamery Salman
Published: January 2021

The development of antimicrobial film for food packaging application had become the focus for researchers and scientists. This research aims to study the characteristics and antimicrobial activity of novel biofilms made of poly (butylene succinate) (PBS) and tapioca starch (TPS) added with 1.5% or 3% of Biomaster-silver (BM) particle. In morphological examination, the incorporation of 3% BM particle was considerably good in forming well-structured PBS film. Meanwhile, the functional groups analysis revealed the 3% BM particle was effectively interacted with PBS molecular chains. The flame retard behavior of BM metal particle also helped in enhancing the thermal stability for pure PBS and PBS/TPS films. The nucleating effect of BM particles had improved the films crystallinity. Small pore size features with high barrier property for gas permeability was obtained for BM filled PBS/TPS films. From antimicrobial analysis, the BM particles possessed antimicrobial activity against three bacteria Staphylococcus aureus, Escherichia coli, and Salmonella Typhimurium in which PBS/TPS 3% BM film exhibited strong antimicrobial activity against all tested bacteria, however, PBS/TPS 1.5% BM film exhibited strong antimicrobial activity against E. coli only. Hence, the incorporation of BM into PBS/TPS film could be a sustainable way for developing packaging films to preserve food products.
Recent Advances in the Rejection of Endocrine-Disrupting Compounds from Water Using Membrane and Membrane Bioreactor Technologies: A Review
Authors: Katibi Kamil Kayode , Yunos Khairul Faezah , Che Man Hasfalina , Aris Ahmad Zaharin , bin Mohd Nor Mohd Zuhair , binti Azis Rabaah Syahidah
Published: January 2021

Water is a critical resource necessary for life to be sustained, and its availability should be secured, appropriated, and easily obtainable. The continual detection of endocrine-disrupting chemicals (EDCs) (ng/L or µg/L) in water and wastewater has attracted critical concerns among the regulatory authorities and general public, due to its associated public health, ecological risks, and a threat to global water quality. Presently, there is a lack of stringent discharge standards regulating the emerging multiclass contaminants to obviate its possible undesirable impacts. The conventional treatment processes have reportedly ineffectual in eliminating the persistent EDCs pollutants, necessitating the researchers to develop alternative treatment methods. Occurrences of the EDCs and the attributed effects on humans and the environment are adequately reviewed. It indicated that comprehensive information on the recent advances in the rejection of EDCs via a novel membrane and membrane bioreactor (MBR) treatment techniques are still lacking. This paper critically studies and reports on recent advances in the membrane and MBR treatment methods for removing EDCs, fouling challenges, and its mitigation strategies. The removal mechanisms and the operating factors influencing the EDCs remediation were also examined. Membranes and MBR approaches have proven successful and viable to eliminate various EDCs contaminants.
Dually Crosslinked Polymer Networks Incorporating Dynamic Covalent Bonds
Authors: Hammer Larissa , Van Zee Nathan J. , Nicolaÿ Renaud
Published: January 2021

Covalent adaptable networks (CANs) are polymeric networks containing covalent crosslinks that are dynamic under specific conditions. In addition to possessing the malleability of thermoplastics and the dimensional stability of thermosets, CANs exhibit a unique combination of physical properties, including adaptability, self-healing, shape-memory, stimuli-responsiveness, and enhanced recyclability. The physical properties and the service conditions (such as temperature, pH, and humidity) of CANs are defined by the nature of their constituent dynamic covalent bonds (DCBs). In response to the increasing demand for more sophisticated and adaptable materials, the scientific community has identified dual dynamic networks (DDNs) as a promising new class of polymeric materials. By combining two (or more) distinct crosslinkers in one system, a material with tailored thermal, rheological, and mechanical properties can be designed. One remarkable ability of DDNs is their capacity to combine dimensional stability, bond dynamicity, and multi-responsiveness. This review aims to give an overview of the advances in the emerging field of DDNs with a special emphasis on their design, structure-property relationships, and applications. This review illustrates how DDNs offer many prospects that single (dynamic) networks cannot provide and highlights the challenges associated with their synthesis and characterization.
Biobased Thermoplastic Elastomers: Structure-Property Relationship of Poly(hexamethylene 2,5-furanodicarboxylate)-Block-Poly(tetrahydrofuran) Copolymers Prepared by Melt Polycondensation
Authors: Paszkiewicz Sandra , Irska Izabela , Zubkiewicz Agata , Szymczyk Anna , Piesowicz Elżbieta , Rozwadowski Zbigniew , Goracy Krzysztof
Published: January 2021

A series of poly(hexamethylene 2,5-furanodicarboxylate)-block-poly(tetrahydrofuran) (PHF-b-F-pTHF) copolymers were synthesized using a two-stage procedure, employing transesterification and polycondensation. The content of pTHF flexible segments varied from 25 to 75 wt.%. 1H nuclear magnetic resonance (NMR) and Fourier transformed infrared spectroscopy (FTIR) analyses were applied to confirm the molecular structure of the materials. Differential scanning calorimetry (DSC), dynamic mechanical measurements (DMTA), and X-ray diffraction (XRD) allowed characterizing the supramolecular structure of the synthesized copolymers. SEM analysis was applied to show the differences in the block copolymers’ morphologies concerning their chemical structure. The influence of the number of flexible segments in the copolymers on the phase transition temperatures, thermal properties, as well as the thermo-oxidative and thermal stability was analyzed. TGA analysis, along with tensile tests (static and cyclic), confirmed the utilitarian performance of the synthesized bio-based materials. It was found that an increase in the amount of pTHF caused the increase of both number-average and weight-average molecular weights and intrinsic viscosities, and at the same time causing the shift of the values of phase transition temperatures toward lower ones. Besides, PHF-b-F-pTHF containing 75 wt.% of F-pTHF units was proved to be a promising thermoplastic shape memory polymer (SMP) with a switching temperature of 20 °C.
Polyferrocenylsilane Semicrystalline Polymer Additive for Solution-Processed p-Channel Organic Thin Film Transistors
Authors: He Zhengran , Zhang Ziyang , Asare-Yeboah Kyeiwaa , Bi Sheng , Chen Jihua , Li Dawen
Published: January 2021

In this study, we demonstrated for the first time that a metal-containing semicrystalline polymer was used as an additive to mediate the thin film morphology of solution-grown, small-molecule organic semiconductors. By mixing polyferrocenylsilane (PFS) with an extensively-studied organic semiconductor 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS pentacene), PFS as a semicrystalline polymer independently forms nucleation and crystallization while simultaneously ameliorating diffusivity of the blend system and tuning the surface energies as a result of its partially amorphous property. We discovered that the resultant blend film exhibited a 6-fold reduction in crystal misorientation angle and a 3-fold enlargement in average grain width. Enhanced crystal orientation considerably reduces mobility variation, while minimized defects and trap centers located at grain boundaries lessen the adverse impact on the charge transport. Consequently, bottom-gate, top-contact organic thin film transistors (OTFTs) based on the TIPS pentacene/PFS mixture yielded a 40% increase in performance consistency (represented by the ratio of average mobility to the standard deviation of mobility). The PFS semicrystalline polymer-controlled crystallization can be used to regulate the thin film morphology of other high-performance organic semiconductors and shed light on applications in organic electronic devices.
Fast Fabrication of Nanostructured Films Using Nanocolloid Lithography and UV Soft Mold Roller Embossing: Effects of Processing Parameters
Authors: Lee Demei , Tang Ya-Ling , Liu Shih-Jung
Published: January 2021

We report the fabrication of nanofeatured polymeric films using nanosphere lithography and ultraviolet (UV) soft-mold roller embossing and show an illuminative example of their application to solar cells. To prepare the nanofeatured template, polystyrene nanocolloids of two distinct sizes (900 and 300 nm) were overlaid on silicon substrates using a spin coater. A lab-made soft-mold roller embossing device equipped with a UV light source was adopted. A casting method was employed to replicate the nanofeatured template onto polydimethylsiloxane, which was used as the soft mold. During the embossing procedure, the roller was driven by a step motor and compressed the UV-curable resin against the glass substrate to form the nanofeatured layer, which was subsequently cured by UV radiation. Polymer films with nanoscaled features were thus obtained. The influence of distinct processing variables on the reproducibility of the nanofeatured films was explored. The empirical outcomes demonstrate that UV soft-mold roller embossing offers a simple yet potent way of producing nanofeatured films.
Preparation and Characterization of Ionic Conductive Poly(acrylic Acid)-Based Silicone Hydrogels for Smart Drug Delivery System
Authors: Kim Young-Ah , Jeong Jin-Oh , Park Jong-Seok
Published: January 2021

In this study, we developed a smart drug delivery system that can efficiently deliver the required amounts of drugs using the excellent ion conductivity of poly(acrylic acid) (PAA) and an electrical stimulus. As a result of its having carboxyl groups, PAA hydrogel can be used in drug delivery patches to release drugs by ionic conductivity. However, PAA hydrogel has low durability and poor mechanical properties. The carboxyl group of PAA was combined with a siloxane group of silicone using electron-beam irradiation to easily form a crosslinked structure. The PAA–silicone hydrogel has excellent mechanical properties. Specifically, the tensile strength increased more than 3.5 times. In addition, we observed its cell compatibility using fluorescence staining and CCK-8 assays and found good cell viability. Finally, it was possible to control the drug delivery rate efficiently using the voltage applied to the ion-conductive hydrogel. As the voltage was increased to 3, 5, and 7 V, the amount of drug released was 53, 88, and 96%, respectively. These excellent properties of the PAA–silicone hydrogel can be used not only for whitening or anti-wrinkling cosmetics but also in medical drug-delivery systems.
Optical Assessment of Porosity Parameters in Transparent Woven Fabrics
Authors: Kostajnšek Klara , Zupin Živa , Hladnik Aleš , Dimitrovski Krste
Published: January 2021

This paper deals with the possibility of a fast and accurate assessment of the number, size, and distribution of pores in transparent woven fabrics based on light penetration. The procedure of analyzing the pore structure in the fabrics based on a digital image is presented in detail. Fabric pores are treated as image particles and analyzed with the Java-based image processing software ImageJ. The obtained data relate to the constructional parameters of the fabric that allow for further analysis, provide the possibility to compare structurally similar or different samples as well as double check the results generated by optical or other means. This paper describes work on plain and similar to plain weaves. The conducted analysis revealed several expected and some unexpected results. Among the former, we can list the range of pore sizes in the examined woven fabrics, the distribution of pores in regard to their similarity, and the effect of dents. Examples of the latter are the magnitude of the cumulative percentage of pores in regard to the weave and the degree to which they participate in the inter-yarn and inter-fiber pores.
Conceptual Design of a Negative Emissions Polygeneration Plant for Multiperiod Operations Using P-Graph
Authors: Pimentel Jean , Orosz Ákos , Aviso Kathleen B. , Tan Raymond R. , Friedler Ferenc
Published: January 2021

Reduction of CO2 emissions from industrial facilities is of utmost importance for sustainable development. Novel process systems with the capability to remove CO2 will be useful for carbon management in the future. It is well-known that major determinants of performance in process systems are established during the design stage. Thus, it is important to employ a systematic tool for process synthesis. This work approaches the design of polygeneration plants with negative emission technologies (NETs) by means of the graph-theoretic approach known as the P-graph framework. As a case study, a polygeneration plant is synthesized for multiperiod operations. Optimal and alternative near-optimal designs in terms of profit are identified, and the influence of network structure on CO2 emissions is assessed for five scenarios. The integration of NETs is considered during synthesis to further reduce carbon footprint. For the scenario without constraint on CO2 emissions, 200 structures with profit differences up to 1.5% compared to the optimal design were generated. The best structures and some alternative designs are evaluated and compared for each case. Alternative solutions prove to have additional practical features that can make them more desirable than the nominal optimum, thus demonstrating the benefits of the analysis of near-optimal solutions in process design.
Technologies and Extraction Methods of Polyphenolic Compounds Derived from Pomegranate (Punica granatum) Peels. A Mini Review
Authors: Lampakis Dimitrios , Skenderidis Prodromos , Leontopoulos Stefanos
Published: January 2021

The interest in using plant by-product extracts as functional ingredients is continuously rising due to environmental and financial prospects. The development of new technologies has led to the achievement of aqueous extracts with high bioactivity that is preferable due to organic solvents nonuse. Recently, widely applied and emerging technologies, such as Simple Stirring, Pressure-Applied Extraction, Enzymatic Extraction, Ultrasound-Assisted Extraction, Pulsed Electric Fields, High Hydrostatic Pressure, Ohmic Heating, Microwave Assistant Extraction and the use of “green” solvents such as the deep eutectic solvents, have been investigated in order to contribute to the minimization of disadvantages on the extraction of bioactive compounds. This review is focused on bioactive compounds derived from pomegranate (Punica granatum) peels and highlighted the most attractive extraction methods. It is believed that these findings could be a useful tool for the pomegranate juices industry to apply an effective and economically viable extraction process, transforming a by-product to a high added value functional product.
Position Deviation Control of Drilling Machine Using a Nonlinear Adaptive Backstepping Controller Based on a Disturbance Observer
Authors: Ji Huifu , Liu Songyong
Published: January 2021

Thin coal seam mining is a development direction to solve the problem of energy supply at this stage, which cannot be realized by small working space, low automation, and drilling deviation. In this paper, a nonlinear adaptive backstepping controller based on a disturbance observer is proposed and used on a coal auger for position tracking control to achieve directional drilling. Firstly, a nonlinear dynamic model for the deflection control mechanism is built with the consideration of parameter uncertainties and external disturbances. Then, the parameter uncertainty and external disturbance are regarded as a system compound disturbance. Furthermore, a disturbance observer is designed to estimate the system compound disturbance and a nonlinear adaptive backstepping controller was proposed to compensate the system compound disturbance. The upper bound of the compound disturbance, which can effectively reduce the chattering in the directional control process, cannot be obtained easily. A stability analysis of the DCM (deviation control mechanism) with the proposed controller is proved based on the Lyapunov theory. Finally, an electro-hydraulic servo displacement control experimental system with matlab xPC target rapid prototyping technology and a prototype experiment system is established to verify the effectiveness of the proposed control strategy. The experimental results indicate that the proposed controller can yield more satisfactory position tracking performance, such as parameter uncertainties and external disturbances, than the conventional proportion integral derivative (PID) controller and an adaptive backstepping controller. Using the control strategy, technical breakthrough on horizontal directional drilling can be realized for thin coal seam mining.
Is God Listening to My Prayers? Initial Validation of a Brief Measure of Perceived Divine Engagement and Disengagement in Response to Prayer
Authors: Exline Julie J. , Wilt Joshua A. , Harriott Valencia A. , Pargament Kenneth I. , Hall Todd W.
Published: January 2021

Does God listen and respond to prayers? This project provided initial validation for a brief measure of perceived divine engagement and disengagement in response to prayer. As part of a larger project on religious/spiritual struggles among U.S. undergraduates, we used Sample 1 (n = 400) for exploratory factor analysis and Sample 2 (n = 413) for confirmatory factor analysis and initial validity testing. A two-factor model with four items per factor provided acceptable fit. On average, participants reported more divine engagement than disengagement. They endorsed items about God listening more than those about God responding. Divine engagement showed strong positive associations with religiousness and positive-valence variables involving God. Divine disengagement showed strong positive associations with variables suggesting divine struggle or distance. Importantly, both subscales also showed evidence of incremental validity: Divine engagement predicted positive-valence God variables (e.g., secure attachment, collaborative religious coping, gratitude to God, and awareness of God) even when controlling for religiousness and positive God concepts and attitudes. Divine disengagement predicted more spiritual struggles and more negative-valence and distance-related God variables (divine struggle, anxious and distant attachment, and self-directing religious coping) even when controlling for doubt about God’s existence, negative God images, anger/disappointment toward God, and concern about God’s disapproval. In short, this brief new measure shows promise as a tool to assess beliefs about God’s responsiveness to prayer.
Is the EU’s Resource Base of Copper Ore Deposits Large? A Fuzzy Set Theory Approach
Authors: Krzak Mariusz
Published: January 2021

Copper raw materials have not been identified as a critical raw material for the economy of the European Union (EU). Demand for metal for use within the EU is satisfied mainly by imports of raw materials in various processing stages and from recycling. Imports include not only copper concentrates, but also refined metals, alloys, and intermediate and finished products. In terms of EU imports, mining supplies represent a minor share of demand. It is likely that copper demand will grow in the coming decades and that global as well as European reserves of copper will be depleted more rapidly. For Europe, no complete and harmonised dataset presenting estimates of total EU copper resources and reserves exists, with the exception of the attempted Minerals4EU project. In colloquial language, many imprecise concepts aim at describing reality. Classic probability tools cannot be used to describe imperfect information. There are no sharp thresholds between the boundaries of many measurements; instead, smooth transitions are observed. This gradation between full and partial membership and non-membership is not included in classical set theory; thus, the capacity for describing such effects is provided by fuzzy set theory. An attempt is made in the present paper at a fuzzy description of the copper reserve base in the EU countries. The basic terminology of fuzzy sets is presented and useful logical operators are indicated. The copper reserve base in the EU countries was assessed in relation to world reserves and an appraisal of this base within these countries was carried out.
Fast Hyper-Spectral Radiative Transfer Model Based on the Double Cluster Low-Streams Regression Method
Authors: del Águila Ana , Efremenko Dmitry S.
Published: January 2021

Fast radiative transfer models (RTMs) are required to process a great amount of satellite-based atmospheric composition data. Specifically designed acceleration techniques can be incorporated in RTMs to simulate the reflected radiances with a fine spectral resolution, avoiding time-consuming computations on a fine resolution grid. In particular, in the cluster low-streams regression (CLSR) method, the computations on a fine resolution grid are performed by using the fast two-stream RTM, and then the spectra are corrected by using regression models between the two-stream and multi-stream RTMs. The performance enhancement due to such a scheme can be of about two orders of magnitude. In this paper, we consider a modification of the CLSR method (which is referred to as the double CLSR method), in which the single-scattering approximation is used for the computations on a fine resolution grid, while the two-stream spectra are computed by using the regression model between the two-stream RTM and the single-scattering approximation. Once the two-stream spectra are known, the CLSR method is applied the second time to restore the multi-stream spectra. Through a numerical analysis, it is shown that the double CLSR method yields an acceleration factor of about three orders of magnitude as compared to the reference multi-stream fine-resolution computations. The error of such an approach is below 0.05%. In addition, it is analysed how the CLSR method can be adopted for efficient computations for atmospheric scenarios containing aerosols. In particular, it is discussed how the precomputed data for clear sky conditions can be reused for computing the aerosol spectra in the framework of the CLSR method. The simulations are performed for the Hartley–Huggins, O2 A-, water vapour and CO2 weak absorption bands and five aerosol models from the optical properties of aerosols and clouds (OPAC) database.
Remote Sensing for International Peace and Security: Its Role and Implications
Authors: Avtar Ram , Kouser Asma , Kumar Ashwani , Singh Deepak , Misra Prakhar , Gupta Ankita , Yunus Ali P. , Kumar Pankaj , Johnson Brian Alan , Dasgupta Rajarshi , Sahu Netrananda , Besse Rimba Andi
Published: January 2021

Remote sensing technology has seen a massive rise in popularity over the last two decades, becoming an integral part of our lives. Space-based satellite technologies facilitated access to the inaccessible terrains, helped humanitarian teams, support complex emergencies, and contributed to monitoring and verifying conflict zones. The scoping phase of this review investigated the utility of the role of remote sensing application to complement international peace and security activities owing to their ability to provide objective near real-time insights at the ground level. The first part of this review looks into the major research concepts and implementation of remote sensing-based techniques for international peace and security applications and presented a meta-analysis on how advanced sensor capabilities can support various aspects of peace and security. With key examples, we demonstrated how this technology assemblage enacts multiple versions of peace and security: for refugee relief operations, in armed conflicts monitoring, tracking acts of genocide, providing evidence in courts of law, and assessing contravention in human rights. The second part of this review anticipates future challenges that can hinder the applicative capabilities of remote sensing in peace and security. Varying types of sensors pose discrepancies in image classifications and issues like cost, resolution, and difficulty of ground-truth in conflict areas. With emerging technologies and sufficient secondary resources available, remote sensing plays a vital operational tool in conflict-affected areas by supporting an extensive diversity in public policy actions for peacekeeping processes.
An Improved Segmentation Method for Automatic Mapping of Cone Karst from Remote Sensing Data Based on DeepLab V3+ Model
Authors: Fu Han , Fu Bihong , Shi Pilong
Published: January 2021

The South China Karst, a United Nations Educational, Scientific and Cultural Organization (UNESCO) natural heritage site, is one of the world’s most spectacular examples of humid tropical to subtropical karst landscapes. The Libo cone karst in the southern Guizhou Province is considered as the world reference site for these types of karst, forming a distinctive and beautiful landscape. Geomorphic information and spatial distribution of cone karst is essential for conservation and management for Libo heritage site. In this study, a deep learning (DL) method based on DeepLab V3+ network was proposed to document the cone karst landscape in Libo by multi-source data, including optical remote sensing images and digital elevation model (DEM) data. The training samples were generated by using Landsat remote sensing images and their combination with satellite derived DEM data. Each group of training dataset contains 898 samples. The input module of DeepLab V3+ network was improved to accept four-channel input data, i.e., combination of Landsat RGB images and DEM data. Our results suggest that the mean intersection over union (MIoU) using the four-channel data as training samples by a new DL-based pixel-level image segmentation approach is the highest, which can reach 95.5%. The proposed method can accomplish automatic extraction of cone karst landscape by self-learning of deep neural network, and therefore it can also provide a powerful and automatic tool for documenting other type of geological landscapes worldwide.
Monitoring Key Forest Structure Attributes across the Conterminous United States by Integrating GEDI LiDAR Measurements and VIIRS Data
Authors: Rishmawi Khaldoun , Huang Chengquan , Zhan Xiwu
Published: January 2021

Accurate information on the global distribution and the three-dimensional (3D) structure of Earth’s forests is needed to assess forest biomass stocks and to project the future of the terrestrial Carbon sink. In spite of its importance, the 3D structure of forests continues to be the most crucial information gap in the observational archive. The Global Ecosystem Dynamics Investigation (GEDI) Light Detection and Ranging (LiDAR) sensor is providing an unprecedented near-global sampling of tropical and temperate forest structural properties. The integration of GEDI measurements with spatially-contiguous observations from polar orbiting optical satellite data therefore provides a unique opportunity to produce wall-to-wall maps of forests’ 3D structure. Here, we utilized Visible Infrared Imaging Radiometer Suite (VIIRS) annual metrics data to extrapolate GEDI-derived forest structure attributes into 1-km resolution contiguous maps of tree height (TH), canopy fraction cover (CFC), plant area index (PAI), and foliage height diversity (FHD) for the conterminous US (CONUS). The maps were validated using an independent subset of GEDI data. Validation results for TH (r2 = 0.8; RMSE = 3.35 m), CFC (r2 = 0.79; RMSE = 0.09), PAI (r2 = 0.76; RMSE = 0.41), and FHD (r2 = 0.83; RMSE = 0.25) demonstrated the robustness of VIIRS data for extrapolating GEDI measurements across the nation or even over larger areas. The methodology developed through this study may allow multi-decadal monitoring of changes in multiple forest structural attributes using consistent satellite observations acquired by orbiting and forthcoming VIIRS instruments.