bluuebunny/crossref_metadata_2025 huggingface dataset:
Seismic behavior of braced steel frames with pipe dampers
Authors: Abdollahiparsa Hossein , Mahboubi Behnam , Zohari Alireza , Abdollahiparsa Saeid
Published: December 2020

Steel pipe dampers offer advantages such as a simple structure, low cost, high energy absorption and dissipation, consistent functionality under cyclic loading, and ductility. Dual-pipe dampers show improved performance over single pipe dampers in terms of strength. The current study focused on the structural performance of the dual-pipe system. The seismic performance of steel-framed structures having 4, 8, or 16 stories with either a simple moment frame or a braced frame equipped with pipe dampers were subjected to seismic loading and investigated using the finite element method. The performance of the models was examined by considering the base shear and lateral displacement of the roof as well as the von Mises distribution. The stress distribution caused by the plastic damage concentration increased in the pipe dampers in the 4- and 8-story models and the base shear decreased 50% in the 4-story models equipped with a pipe damper. The results showed that, in the 16-story models, the strength in the damping system should be designed in accordance with the other elements. In addition, the strength of the damping system can be increased by increasing the number of pipes and their thickness.
Moisture buffering effect of hygroscopic materials under wall moisture transfer
Authors: Yang Ming , Kong Fanhong , He Xuancheng
Published: December 2020

Hygroscopic material can moderate the indoor humidity variation due to its moisture buffering effect. This effect would change when used as interior finish mainly due to air exchange and wall moisture transfer. The author focused on clarifying the extent of the wall'’s influence on indoor moisture buffering and building humidity environment. A room model was established and the situation of no wall moisture transfer was simulated by adding a vapour barrier between the interior finish and the wall. Comparing this result with wall moisture transfer, the moisture buffering effect of the wall can be quantitatively analysed. The results verify that the buffering effect and the humidity environment, especially the seasonal buffering, change with the wall moisture transfer. The wall has great impacts on buffering in the cases of thin interior finish, high moisture production and low ventilation. Because the layer under the hygroscopic material also has buffering capacity, the difference of using various thicknesses of material is not obvious. Frequent ventilation reduces the buffering effect but improves the RH optimality.
Differentiating Depression From Demoralization in Organ Transplantation Recipients
Authors: Rzeszut Mary , Assael Rachel
Published: December 2020

Living with end stage organ failure and transplantation has implications for physiological, psychological, and social well-being. The development of anxiety or depressive disorders are common with demoralization, another psychological syndrome, a topic of interest in psychiatry. To feel demoralized is to lose hope, courage, or confidence, which upsets normal functioning. While depression may co-exist with demoralization, they are 2 distinct entities, with the former characterized by an inability to experience pleasure and the latter characterized by helplessness and avoidance coping. In an effort to more adequately address the psychological stress in organ transplant patients, it is important to distinguish between demoralization and depression. Demoralization has prognostic implications such as negative disease outcomes such as treatment nonadherence and an increase risk of suicide. Medication for depression is not effective for demoralization syndrome. Therapeutic interventions include cognitive behavioral techniques that focus on exploration of attitudes toward hope and meaning in life.
MiR-124-5p Inhibits the Progression of Gastric Cancer by Targeting MIEN1
Authors: Liang Feng , Zhang HongYan , Qiu YuXuan , Xu QianRu , Jian KaiYu , Jiang Lin , Wang Fei , Lu Xin
Published: December 2020

Objective:

To observe the effect of miR-124-5p on progression of gastric cancer (GC) and explore the targeting mechanism.

Methods:

After collecting the specimens, we used real-time fluorescence quantitative PCR to detect the miR-124-5p level of GC tissue and corresponding adjacent tissue. Then MTT test and scratch wound-healing assay were hired to evaluate the influence of miR-124-5p in GC cell (SGC-803 and SGC7901) migration and proliferation ability. The binding of miR-124-5p to migration and invasion enhancer 1 (MIEN1) was detected through dual luciferase reporter gene experiment and western blot was utilized to assay the protein level of MIEN1.

Results:

Compared with adjacent tissues, miR-124-5p level in GC tissues was lower significantly. MiR-124-5p mimic inhibited the metastasis and proliferation ability of SGC7901 cells and miR-124-5p inhibitor promoted the migration and proliferation ability of SGC803 cells. In addition, miR-124-5p targeted MIEN1 and negatively modulated the MIEN1 expression in SGC-803 and SGC7901 cells. Silencing MIEN1 negatively regulated the metastasis and proliferation ability of SGC7901 cells.

Conclusion:

MiR-124-5p inhibited the GC cell proliferation and metastasis phenotypes through MIEN1, which probably becomes a novel molecular target for clinical GC treatment.
San Huang Decoction Targets Aurora Kinase A to Inhibit Tumor Angiogenesis in Breast Cancer
Authors: Xu Yanlei , Wang Cong , Chen Xiyan , Li Yongfei , Bian Weihe , Yao Chang
Published: December 2020

San Huang Decoction (SHD), a Chinese herb formula, has been popularly prescribed in the clinical treatment of patients suffering from breast cancer. The aim of this study was to explore the anti-angiogenic effects of SHD in breast cancer and explain the underlying mechanism. Transwell and Matrigel assays showed that SHD reduced human umbilical vein endothelial cell migration and tubule formation and ELISA and qRT-PCR assays demonstrated its mediation of vascular endothelial growth factor (VEGF) expression. siRNA silencing of aurora kinase A (AURKA) produced results similar to those obtained by inhibition of AURKA with SHD. In addition, a chorioallantoic membrane assay was carried out to directly examine the effect of SHD on breast cancer anti-angiogenesis and immunofluorescence and immunohistochemical staining analysis showed that SHD reduced the expression of CD31, AURKA, and VEGF in a xenograft model. Furthermore, SHD regulated extracellular signal-regulated kinase expression in breast cancer cells, which was examined by western blotting. In conclusion, our findings indicated that SHD treatment mimicked the decrease in tumor neovascularization in breast cancer cells after the siRNA-mediated knockdown of AURKA. Thus, SHD may inhibit tumor angiogenesis in breast cancer by targeting AURKA and downregulating the ERK signaling pathway.
Extracting Chinese geographic data from Baidu Map API
Authors: Xue Yuan , Li Chuntao
Published: December 2020

In this article, we describe the two new commands cngcode and cnaddress, which can be used to link Chinese addresses to locations defined by their longitudes and latitudes through Baidu Map API v3.0 ( http://api.map.baidu.com ), an online map and navigation system widely used in China. cngcode transfers Chinese addresses to locations, whereas cnaddress does the opposite. These two commands make it easier with Stata to deal with addresses and locations in China.
Nonparametric synthetic control using the npsynth command
Authors: Cerulli Giovanni
Published: December 2020

In this article, I build on the work of Abadie and Gardeazabal (2003, American Economic Review 93: 113–132) and Abadie, Diamond, and Hainmueller (2010, Journal of the American Statistical Association 105: 493–505), extending the synthetic control method for program evaluation—implemented in Stata via the community-contributed command synth—to the case of a nonparametric identification of the synthetic (or counterfactual) time pattern of a treated unit (a country, a region, a city, etc.) subject to a specific intervention in a given time. After theoretical description of the model, I present npsynth, the command I developed for estimating the nonparametric synthetic control method proposed in this article. Using both simulated and real data, I set out a comparison of the performance of the parametric and nonparametric methods and widely discuss the results.
Techniques of Identity Talk in Reentering Mothers’ Self-Narratives: (M)othering and Redemption Narratives
Authors: De Coster Stacy , Heimer Karen
Published: December 2020

We examine how incarcerated women introduced themselves to a reentry program focused on reuniting them with their children. To communicate maternal worthiness, the women did not discuss their own past mothering but focused instead on their mothers’ mothering and on their future mothering. Our analysis uncovers two forms of identity talk women used to distance themselves from societal presumptions about their “bad” mothering: discussing shortcomings of their mothers in a process we call defensive (m)othering, and focusing on futures as good mothers through redemptive storytelling. These strategies reveal how women attempt to manage identities within structural, cultural, and situational constraints.
Lumbrical Muscles Neural Branching Patterns: A Cadaveric Study With Potential Clinical Implications
Authors: Colonna Michele R. , Piagkou Maria , Monticelli Andrea , Tiengo Cesare , Bassetto Franco , Sonda Regina , Battiston Bruno , Titolo Paolo , Tos Pierluigi , Fazio Antonina , Costa Alfio Luca , Galeano Mariarosaria , Porzionato Andrea , De Caro Raffaele , Cucinotta Filippo , Anastasopoulos Nikolaos , Papadopulos Nikolaos A. , Geuna Stefano , Natsis Konstantinos
Published: December 2020

Background

Lumbrical muscles originate in the palm from the 4 tendons of the flexor digitorum profundus and course distally along the radial side of the corresponding metacarpophalangeal joints, in front of the deep transverse metacarpal ligament. The first and second lumbrical muscles are typically innervated by the median nerve, and third and fourth by the ulnar nerve. A plethora of lumbrical muscle variants has been described, ranging from muscles’ absence to reduction in their number or presence of accessory slips. The current cadaveric study highlights typical and variable neural supply of lumbrical muscles.

Materials

Eight (3 right and 5 left) fresh frozen cadaveric hands of 3 males and 5 females of unknown age were dissected. From the palmar wrist crease, the median and ulnar nerve followed distally to their terminal branches. The ulnar nerve deep branch was dissected and lumbrical muscle innervation patterns were noted.

Results

The frequency of typical innervations of lumbrical muscles is confirmed. The second lumbrical nerve had a double composition from both the median and ulnar nerves, in 12.5% of the hands. The thickest branch (1.38 mm) originated from the ulnar nerve and supplied the third lumbrical muscle, and the thinnest one (0.67 mm) from the ulnar nerve and supplied the fourth lumbrical muscle. In 54.5%, lumbrical nerve bifurcation was identified.

Conclusion

The complex innervation pattern and the peculiar anatomy of branching to different thirds of the muscle bellies are pointed out. These findings are important in dealing with complex and deep injuries in the palmar region, including transmetacarpal amputations.
8-Hydroxy-2’-Deoxyguanosine and 8-Nitroguanine Production and Detection in Blood Serum of Breast Cancer Patients in Response to Postoperative Complementary External Ionizing Irradiation of Normal Tissues
Authors: Verigos Kosmas E. , Sagredou Sofia , Orfanakos Kyriakos , Dalezis Panayiotis , Trafalis Dimitrios T.
Published: December 2020

It is widely known that ionizing irradiation is strongly linked to the production of reactive oxygen (ROS) and nitrative species (RNS) through which DNA damage products like 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NG) are generated, respectively. In the present study, we aimed to investigate the formation of 8-OHdG and 8-NG upon irradiation and to further explore whether alterations in their concentration levels are related to the administered radiation doses and exposure time. Our research work was conducted in blood serum samples collected from 33 breast cancer patients who received adjuvant radiotherapy. The detection of 8-OHdG and 8-NG was assessed by enzyme-linked immunosorbent assay. Our results suggest that both, 8-OHdG and 8-NG, were formed during the radiation regimen. Significant correlations with radiation dose were also demonstrated by the dose-response curves of 8-OHdG and 8-NG, fitted by logarithmic distribution and polynomial regression, respectively. More precisely, 8-OHdG and 8-NG concentrations (ng/mL) were considerably increased when patients received ionizing radiation up to 30 Gy whereas irradiation over 30 Gy did not induce any further increases. The current study supports a) the production of 8-OHdG and 8-NG during radiotherapy and b) significant correlations between either 8-OHdG or 8-NG levels and radiation doses, indicating a radiation-dose-dependent relationship.
Construction of Radiation Surviving/Resistant Lung Cancer Cell Lines with Equidifferent Gradient Dose Irradiation
Authors: Wang Lijuan , Li Shangbiao , Zhu Xiaoxia
Published: December 2020

Radiotherapy plays an increasingly crucial role in the treatment of non-small cell lung cancer (NSCLC). Local tumor recurrence and tumor progression caused by intratumoral heterogeneity induced radiotherapy resistance remain the primary causes of radiotherapy failure. However, the lack of a suitable cell line model has hampered the exploration of the dynamic mechanisms of radiation resistance. We established 3 groups of equidifferent gradient dose irradiation surviving/resistant human lung cancer cell lines based on A549, H520, and H460 cells with clinical conventional fractionated radiotherapy (CFRT) (2 Gy × 20 F, 2 Gy × 30 F, and 2 Gy × 40 F). The radiosensitivity of the cells was detected by clone formation assay, EDU cell proliferation assay, neutral comet assay, and γ-H2AX immunofluorescence staining. The radiosensitivity and proliferation viability were increased in a received dose-dependent manner. Compared with parental cells, DNA double-strand breaks (DSBs) in cell lines that received higher-dose irradiation were significantly reduced. We successfully constructed equidifferent gradient dose irradiation surviving/resistant NSCLC cell lines whose radiation surviving and resistant abilities were increased in a received dose-dependent manner. This preclinical cell model could be used to dynamically observe and detect the radiation surviving/resistant biomarkers during radiotherapy stress, elucidate the mechanism of radiation resistance.
Effectiveness of combined superficial femoral artery endovascular therapy with popliteal-to-distal bypass: A paradigm shift in surgical open bypass for chronic limb-threatening ischemia
Authors: Kobayashi Taira , Hamamoto Masaki , Okazaki Takanobu , Hasegawa Misa , Fujiwara Takashi , Takahashi Shinya
Published: December 2020

Objectives

The purpose of this study was to evaluate the results of combining superficial femoral artery endovascular therapy with distal bypass originating from the popliteal artery as a method of lower extremity revascularization in patients with chronic limb-threatening ischemia.

Methods

The records of patients undergoing combined superficial femoral artery endovascular therapy with popliteal-to-distal bypass for chronic limb-threatening ischemia from January 2014 to April 2020 at a single institution were retrospectively reviewed. The patients’ background, operative details, and long-term outcomes were analyzed.

Results

Fifty-two popliteal-to-distal bypasses with superficial femoral artery endovascular therapy were performed in 49 patients (33 men; mean age, 76 ± 9 years; diabetes mellitus, 80%; end-stage renal disease with hemodialysis, 47%). The Trans-Atlantic Inter-Society Consensus II classification of superficial femoral artery–popliteal lesion was “A” in 8 (15%) patients, “B” in 14 (27%) patients, “C” in 24 (46%) patients, and “D” in 6 (12%) patients. The intervention for superficial femoral artery lesions was plain old balloon angioplasty in 4 patients, self-expandable nitinol stent in 15 patients, drug-coated balloon in 18 patients, drug-eluting stent in 4 patients, stent graft in 10 patients, and interwoven nitinol stent in 1 patient. Distal bypass originated from the above-knee popliteal artery in 9 (17%) limbs and the below-knee popliteal artery in 43 (83%) limbs. The most common outflow artery was the posterior tibial artery (44%). The mean follow-up period was 17 ± 17 months. The primary and secondary patency of the graft was 44% and 72%, respectively, at 1 year and 39% and 72%, respectively, at 3 years. Primary patency and freedom from clinical-driven target lesion revascularization of superficial femoral artery endovascular therapy lesions were 85% and 90%, respectively, at 1 year and 63% and 75%, respectively, at 3 years. Limb salvage was 97% at 1 year and 92% at 3 years. Wound healing was 67% at 6 months and 83% at 12 months.

Conclusions

Combined superficial femoral artery endovascular therapy with popliteal-to-distal bypass may be a promising approach for patients with chronic limb-threatening ischemia because of durable patency, acceptable wound healing, and good limb salvage.
The effectiveness of percutaneous mechanical thrombectomy in the treatment of acute thromboembolic occlusions of lower extremity
Authors: Liu Liguo , Zhang Xiujun , Huang Mei , Li Junhai , Zhao Ziyuan , Huang Junjie
Published: December 2020

Objectives

The objective of this study was to evaluate the effectiveness of percutaneous mechanical thrombectomy as the initial thrombus removal method in the treatment of acute lower extremity ischemia.

Methods

The patients with acute lower limb ischemia who underwent percutaneous mechanical thrombectomy between August 2016 and February 2018 were retrospectively reviewed. The patients were diagnosed by clinical examination and computed tomography angiography. The percutaneous mechanical thrombectomy was performed as the initial thrombus removal method, followed by anticoagulation therapy. The patients were followed up by clinical examination, imaging, and ankle brachial index (ABI) examination.

Results

Thirty-two patients (21 males, 11 females; average age of 68.53 ± 8.05; three cases of grade III, 29 cases of grade IIB) were reviewed. Recanalization of the thromboembolic occlusions were achieved in all patients. ABI significantly ( p < 0.01) increased postoperatively (preoperative ABI: 0.51 ± 0.13; postoperative ABI: 0.85 ± 0.65, ABI at three months postoperatively: 0.84 ± 0.66). Eleven patients underwent balloon dilation and three patients had stent placement. Complete thrombus removal was achieved in all patients. The primary patency at 3 months, 6 months, and 12 months postoperatively was 90%, 85%, and 56%, respectively. The secondary patency at 3 months, 6 months, and 12 months postoperatively was 93%, 87%, and 65%, respectively.

Conclusions

The immediate result appeared to be effective to use percutaneous mechanical thrombectomy as the first thrombus removal method in the treatment of acute thromboembolic occlusions in the lower extremity, while the midterm result needs to be further improved.
The democratic school experiences framework: A tool for the design and self-assessment of democratic experiences in formal education
Authors: de Groot Isolde , Lo Jane
Published: December 2020

In many democratic societies, schools are expected to prepare their students for participation in democratic societies. (Self)assessment frameworks, designed by scholars and curriculum developers, support the development of school initiated democratic experiences. Existing frameworks, however, are not designed to capture the interplay between the practices organized, related educational activities, and the types of aims pursued in education programs. To address this void, this paper presents an eight-sectored framework that captures the multiplicity of democratic education and participation in schools.
Efficacy of infliximab treatment on the mucosal healing of different intestinal segments in patients with ileocolonic Crohn’s disease
Authors: Wu Yaling , Zhang Lei , Cao Jingli , Wang Haichao , Ye Chen , Zhuoma Deji , Yang Pengyu , Wang Xiaolei
Published: December 2020

Background:

Mucosal healing (MH) is the key aim of the treat-to-target strategy for patients with Crohn’s disease (CD). The efficacy of infliximab (IFX) on MH in different ileocolonic segments is unclear. The aim of this study was to investigate endoscopic MH in different ileocolonic segments in patients with CD who received IFX treatment.

Methods:

A retrospective, single-center study was performed in patients with active ileocolonic CD between January 2012 and December 2018. All patients underwent IFX treatment for at least 30 weeks. The MH of five ileocolonic segments was assessed by the Simple Endoscopic Score for CD (SES-CD) at baseline, 14/22 weeks and 30/38 weeks. The SES-CD values were analyzed by a mixed-effects model after the correction for confounding factors.

Results:

A total of 101 eligible patients were included. The baseline endoscopic severity was similar across segments. At 30/38 weeks, the greatest changes in the SES-CD ulcer size and ulcerated surface subscores were −94.29% and −94.32% both in the transverse colon ( p < 0.0001), and the smallest changes were −67.88% and −69.67% both in the terminal ileum ( p < 0.0001) compared with baseline. Stenosis mainly presented in the right colon (12/29, 41.38%). The change in the SES-CD stenosis subscore was −6.25% in the right colon at 30/38 weeks compared with −71.88% at 14/22 weeks ( p = 0.0030). At 30/38 weeks, the transverse colon achieved the highest rate of complete MH (CMH) at 81.2%, and the lowest CMH rate occurred in the terminal ileum at 45.6%. Moreover, the degree of improvement in the rectum was negatively correlated with disease progression ( p = 0.011).

Conclusions:

Ileocolonic segments in CD presented different degrees of endoscopic MH during IFX treatment. The transverse colon showed the highest CMH rate, whereas the right colon with stenosis showed the poorest improvement. The differing propensities of ileocolonic segments may provide an individualized IFX treatment strategy.
Platelet-to-lymphocyte percentage ratio index: a simple non-invasive index to monitor the endoscopic activity in Crohn’s disease
Authors: Chen Rirong , Li Li , Chao Kang , Hong Mengzhi , Cao Qian , Ye Lingna , Zhou Gaoshi , Fang Xiaoli , Guo Huili , Cao Xiaocang , Ye Xiaoqi , Zeng Zhirong , Chen Minhu , Zhang Shenghong
Published: December 2020

Background:

Recent evidence has shown that the complete blood count (CBC) is abnormal in patients with Crohn’s disease (CD). We aimed to investigate an effective CBC parameter and explore its impact on disease activity in a large CD cohort.

Methods:

We performed a retrospective analysis of patients with established CD who underwent clinically indicated endoscopy at four tertiary centres in China between 2016 and 2020. Individual variables of the Simple Endoscopic Score for CD, CBC parameters, C-reactive protein (CRP) levels, erythrocyte sedimentation rate, and faecal calprotectin (FC) were independently reviewed by different investigators. The hold-out method was used to verify the predictive power of the established model.

Results:

Data from a total of 1388 endoscopic procedures performed for 882 eligible CD patients were available with routine blood parameters and related indicators. The model using platelet-to-lymphocyte percentage ratio (PLpR) had high accuracy for identifying patients in endoscopic remission (ER), with an area under the curve (AUC) of 0.785 [95% confidence interval (CI): 0.784–0.787], which was comparable with that for CRP (AUC: 0.775, 95% CI: 0.774–0.777). Notably, the AUC of PLpR was significantly higher than that of CRP in patients with colonic disease and with a history of surgery. Moreover, after combining the FC with PLpR, the AUC value of FC + PLpR increased up to 0.892 (95% CI: 0.890–0.894) for identifying ER.

Conclusions:

We explored an index (PLpR) to identify CD patients in ER based on platelet and lymphocyte percentage from the CBC. PLpR helped evaluate the degree of disease activity and monitor the therapeutic response.
Technical and clinical outcomes of endoscopic retrograde cholangiopancreatography (ERCP) procedures performed in patients with COVID-19
Authors: Voiosu Theodor , Voiosu Andrei , Boškoski Ivo , Arvanitakis Marianna , Bronswijk Michiel , Hollenbach Marcus , Benguş Andreea , Bălănescu Paul , Orlandini Beatrice , Blero Daniel , Van der Merwe Schalk , Mateescu Radu Bogdan , Devière Jacques , Costamagna Guido
Published: December 2020

Background:

The unprecedented situation caused by the coronavirus disease 2019 (COVID-19) pandemic has profoundly affected endoscopic practice in regard to access, volume, and workflow. We aimed to assess the potential changes in the technical outcomes of endoscopic retrograde cholangiopancreatography (ERCP) procedures carried out in patients with confirmed SARS-CoV-2 infection.

Methods:

We conducted an international, multicenter, retrospective, matched case-control study of ERCP procedures carried out in patients with confirmed COVID-19. The main outcome was technical success of the procedure as assessed by the endoscopist, and the secondary outcome was the development of procedure-related adverse events. Each case was matched in a 1:4 ratio with controls extracted from each center’s database in order to identify relevant changes in outcome measures compared with the pre-pandemic era.

Results:

Eighteen procedures performed in 16 COVID-19 patients [14 men, 65 years (9–82)] and 67 controls were included in the final analysis. Technical success was achieved in 14/18 COVID-19 cases, which was significantly lower as compared with the control group (14/18 versus 64/67, p = 0.034), with an endoscopic reintervention required in 9/18 cases. However, the rate of procedure-related adverse events was low in both groups (1/18 versus 10/67, p = 0.44). On multivariable analysis, COVID-19 status remained the only risk factor for technical failure of the procedure [odds ratio of 19.9 (95% confidence interval 1.4–269.0)].

Conclusions:

The COVID-19 pandemic has affected the volume and practice of ERCP, resulting in lower technical success rates without significantly impacting patient safety. Prioritizing cases and following recommendations on safety measures can ensure good outcome with minimal risk in dedicated centers.
The Degree of Ulcerative Colitis Burden of Luminal Inflammation score is superior to predicting medium- to long-term prognosis in patients with active ulcerative colitis
Authors: Chen Liang , Yang Jiaolan , Fang Leilei , Wu Wei , Feng Baisui , Shi Yanhong , Sun Mingming , Sun Xiaomin , Liu Zhanju
Published: December 2020

Aims:

The endoscopic evaluation is crucial for the management and treatment of ulcerative colitis (UC). Currently, the Mayo Endoscopic Score (MES) and the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) are two major endoscopic score systems to evaluate the status of mucosal inflammation and disease activity. However, in both MES and UCEIS systems, the disease extent is not included. The Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) score is a simple clinical score which is calculated as a product of the MES (0–3) and the extent of disease (E1–E3). The objective of this study was to compare the correlation among DUBLIN, UCEIS and MES, and also investigate the clinical characteristics for predicting treatment failure in patients with active UC.

Methods:

Between March 2015 and April 2019, 172 patients who were previously diagnosed with UC and had undergone colonoscopy were recruited in this study. We retrospectively reviewed the endoscopic scores and clinical characteristics at the time of the colonoscopy and assessed the prognosis of the patients. Endoscopic response was defined as the decrease in MES ⩾1 grade.

Results:

DUBLIN showed significant correlation with MES ( r = 0.748) and partial Mayo score (pMayo) ( r = 0.707), and moderately correlated with CRP ( r = 0.590). UCEIS also showed strong correlation with MES ( r = 0.712) but moderate correlation with pMayo ( r = 0.609) and CRP ( r = 0.588). Compared with the UCEIS (cut-off value: 4; sensitivity: 75.73%), DUBLIN score (cut-off value: 4; sensitivity: 86.41%) showed higher diagnostic sensitivity than UCEIS score (McNemar test, p < 0.05). Furthermore, a multivariate analysis also revealed that DUBLIN ⩾4 was the independent factor for predicting treatment failure for UC ( p < 0.001, odds ratio: 1.547; 95% confidence interval: 1.32–1.88).

Conclusion:

The DUBLIN score shows superior diagnostic performances in terms of sensitivity value compared with the UCEIS. Moreover, multivariate analysis indicates that DUBLIN ⩾4 is an independent factor for predicting medium- to long-term treatment failure in active UC patients.
Malocclusion Management Following Mandibular Reconstruction With Free Fibula Flaps
Authors: Cantini Ardila Jorge Ernesto , Fuentes Carlos Eduardo Torres , Gomez Giovanni Montealegre , Correa Susana , Gutierrez Erika Paola , Castiblanco Maria Paula , Flechas Francisco Sebastián Carvajal
Published: December 2020

Study Design:

Free fibula flaps are nowadays the gold standard for the surgical reconstruction on large mandibular defects. Malocclusion is an important complication of this type of reconstruction and many of these patients end up requiring subsequent orthognathic corrective surgery. This is a descriptive retrospective case series study.

Objective:

To describe the demographic data, operative techniques, corrective methods and postoperative results in the management of malocclusion following mandibular reconstruction with free fibula flap.

Methods:

This case series study included patients who underwent free fibula flap mandibular reconstructions and who that subsequently developed malocclusion requiring orthognathic corrective surgery, from June 2010 to December 2019. Panoramic X-rays, cephalometries and/or 3-D facial reconstruction CT scans were used for surgical planning to create surgical cutting guides, templates and occlusal splints in all the patients that underwent corrective orthognathic surgery.

Results:

There were 46 patients who underwent a free fibula flap mandibular and maxillary reconstruction at San Jose Hospital between June 2010 and December 2019 of these, 5 patients (10.9%) developed postoperative malocclusion. One case from another institution was added to this study for a total of 6 patients with malocclusion following mandibular reconstruction surgery with a fibula free flap. During the orthognathic surgery, vertical osteotomies were performed in 3 patients and bilateral sagittal split osteotomies were necessary in 2 patients and L-shape in 1 patient. Osteogenic distraction was performed in 3 patients as part of their orthognathic treatment. The fixation methods were based in miniplates for 3 of the patients and lag screws for the remaining 3 patients. With this approach, all patients had an adequate occlusion correction with a 100% consolidation at their 6-month follow up.

Conclusion:

Malocclusion is a significant complication following mandibular reconstruction surgery that must be identified and managed. In severe cases, it requires corrective orthognathic surgery in severe cases. We have developed a protocol to avoid pitfalls during the primary reconstruction and in case an orthognathic surgery is required for malocclusion correction, preoperative planning with cutting guides and occlusal splints should be assessed, to guarantee favorable results through a reproducible technique.
A giant thoraco abdominal wall lipoma in a child
Authors: Aihole Jayalaxmi Shripati
Published: December 2020

Lipomas are benign mesenchymatous soft tissue tumours occurring mostly in the subcutaneous areas of the body. They are usually asymptomatic painless swellings, presenting with a large size in adults. Giant lipomas are rarely reported in adults as well as in children. A case of giant lateral thoracoabdominal wall lipoma in a child has been reported here.
“Such” or “Other”? Options in 1 Corinthians 11.16
Authors: Clark David J.
Published: December 2020

This note summarises the different ways numerous translations have rendered the Greek word toiautēn in 1 Cor 11.16, the implications that the different options could have for interpreting the verse, and how readers in various cultures may perceive Paul’s attitude towards his original readers.
Translating Κύριος after 600 Years of “the Lord’s” Faithful Service
Authors: Bainbridge John T.
Published: December 2020

Much of Western Christianity continues to follow late medieval translation practices in translating yahweh and kurios. Since then, mainstream usage of “Lord” has slumped and evolved, with the little remaining usage often carrying a distinctly sinister connotation. The deep attachment to “Lord” within Christianity constitutes a second problem: although it creates methodological inconsistency, its historical super-sanctified status is likely the reason the terminology seems so impervious to change. Septuagint data highlight a further problem for sustaining “the LORD/Lord,” since doing so creates a grammatical mismatch with kurios (with regard to the definite article). These three problems call for reassessment of the ongoing suitability of “Lord” in English Bible translation and for a more context-driven methodology. This is defined and applied in a range of New Testament contexts for the purposes of demonstrating feasibility (rather than finality).
Pleonasms, Ideophones, and the Song of Songs
Authors: Noss Philip A.
Published: December 2020

In response to two articles by Izaak de Hulster in The Bible Translator, this note describes ideophone use in the Gbaya translation of the Song of Songs as a type of pleonastic translation.
Struggling to be more visible: Female digital creative entrepreneurs in China
Authors: Wang Qing , Keane Michael
Published: December 2020

Entrepreneurs have become the driving force of China’s economy over the past few decades. With a rapid surge in the growth of digital platforms, and the success of China’s platforms outside China, the aspiration to be entrepreneurial is recognized and celebrated. Increasingly, women are benefitting from this entrepreneurial fever. However, behind the increasing number of emerging women digital entrepreneurs, is the struggle to gain recognition. Drawing on cases studies of female digital startups, the article investigates some of the dilemmas faced when women strive to develop entrepreneurial identities. The article problematizes distinctions between the entrepreneur in a general sense, the creative entrepreneur, and female creative entrepreneurs. Whereas an entrepreneur in China is often conflated with a business owner, the identity of the creative entrepreneur is more precarious and unstable. The article finds that besides the difficulty to sustain a creative-based entrepreneurial identity, the hyper-competitive and masculinist fields of digital entrepreneurship and technical fields, combined with traditional gender roles and family responsibility, results in a devaluation of female entrepreneurship.
K-pop boot camps in choreographic co-creative labor
Authors: Liew Kai Khiun , Lee Angela
Published: December 2020

The worldwide popularity of South Korean popular music has generated global consumer demand for variations of its grueling training regimen offered by talent recruitment agencies and dance studios. Using the case study of the South Korean popular music boot camps offered by the Australia-based agency, The Academy, this article seeks to frame these performative engagements along more cosmopolitan notions of choreographic co-creative labor. In contrast to the highly competitive South Korean popular music machinery, participation in these boot camps can be characterized as affective prosumer “free labor” from trainees from diverse backgrounds, abilities, and motivations. Through programs that enable trainees to “re-present,” “re-organize,” and “re-interpret” K-pop dance performances, studios like The Academy leverage on K-pop’s popularity and its training pedagogies so as to open new fields of creative labor. Accompanying such openings are the strengthening transnational connectivities in the activities of The Academy in intensifying existing multicultural networks in Australia. The studio is also part of a more cosmopolitan platform in orienting traditionally Eurocentric mainstream Australia culturally toward the Asia-Pacific region. By further democratizing the dance abilities of K-pop choreographies, initiatives like The Academy serve in enlarging creative labor in transnational rhythmic communities.
The Impact of Age on Negative Emotional Reactions, Compliance With Health Guidelines, and Knowledge About the Virus During the COVID-19 Epidemic: A Longitudinal Study From Israel
Authors: Levkovich Inbar
Published: December 2020

In a longitudinal study we examined the impact of age on negative emotional reactions, compliance with health guidelines and knowledge about the virus during the COVID-19 epidemic. A total of 2509 people participated in a two-phase study: 1424 participants in the first phase (March 12-21) and 1085 participants in the second phase (April 23 to May 5). Age was categorized into 4 groups: age 18 to 30, age 31 to 40, age 41 to 50, and age 51 and over. In the first and second phase, compliance with health guidelines was highest among participants over the age of 50. Knowledge was significantly higher in the second phase than in the first among participants over age 50 and those between the ages of 40 and 50. In the second phase, knowledge did not differ by age group. Negative emotional reactions were significantly higher in the first phase than in the second. Moreover, negative emotional reactions were higher among participants up to age 30 than among all other participants. Perceived susceptibility did not differ by phase or by age group. The paper underscores the impact of age during the COVID-19 epidemic and points to the necessity of taking the needs of different age groups into consideration.
Are There Predictors of Success for Students With Disabilities Pursuing Postsecondary Education?
Authors: Madaus Joseph W. , Gelbar Nicholas , Dukes Lyman L. , Taconet Ashley , Faggella-Luby Michael
Published: December 2020

Students with disabilities are entering college in increasing numbers. Despite the increase, college persistence and completion remains a troublesome hurdle. Evidence-based practices and predictors have been identified for secondary-level students with disabilities; however, a parallel classification does not exist for postsecondary education. The purpose of this systematic review was to determine whether there are evidence-based predictors of college success with regard to retention, academic achievement, and graduation. Results indicated that although there are an insufficient number of studies to validate a core set of evidence-based practices at this time, there are a series of student-related practices that positively predict grade point average, retention, and graduation that warrant future investigation.
Exploring a Common Data Element for International Research in Long-Term Care Homes: A Measure for Evaluating Nursing Supervisor Effectiveness
Authors: McGilton Katherine S. , Backman Annica , Boscart Veronqiue , Chu Charlene , Gea Sánchez Montserrat , Irwin Constance , Meyer Julienne , Spilsbury Karen , Zheng Nancy , Zúñiga Franziska
Published: December 2020

The aim of this study is to recommend a common data element (CDE) to measure supervisory effectiveness of staff working in LTC homes that can be used in international research. Supervisory effectiveness can serve as a CDE in an effort to establish an international, person-centered LTC research infrastructure in accordance with the aims of the WE-THRIVE group (Worldwide Elements to Harmonize Research in Long Term Care Living Environments). A literature review was completed and then a panel of experts independently reviewed and prioritized appropriateness of the measures with mindfulness of their potential applications to international LTC settings. The selection of a recommended CDE measure was guided by the WE-THRIVE group’s focus on capacity rather than deficits, the expected availability of internationally comparable data and the goal to provide a short, ecologically viable measurement, specifically for low- and middle-income countries. Two measures were considered as the CDE for supervisory effectiveness, Benjamin Rose Relationship Scale and the Supervisory Support Scale; however, given that the latter measure has been translated in Spanish and Chinese and has been tested with nursing assistants in both of these countries with good psychometric properties, our group recommends it as the CDE going forward.
Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction
Authors: Azhar Gohar , Raza Sakeena , Pangle Amanda , Coleman Kellie , Dawson Amanda , Schrader Amy , Wolfe Robert R. , Wei Jeanne Y.
Published: December 2020

Approximately half of heart failure patients in the US have heart failure with preserved ejection fraction (HFpEF). HFpEF impairs physical performance and thus reduces quality of life. Increasing dietary protein intake can increase lean body mass and physical performance in healthy elderly individuals, but the effect of a high-quality protein supplement, with or without a structured exercise program, has not been investigated in HFpEF patients. Twenty-three obese elderly HFpEF patients with grade 1 or 2 diastolic dysfunction were randomized into three groups: control, protein supplementation alone, and protein plus exercise. Protein supplementation involved providing sufficient whey protein so that total intake was 1.2 g protein/kg/day. The exercise intervention was 2 days of hydrotherapy and 1 day of gym sessions per week under supervision of a fitness expert. Physical parameters and functional tests were performed at baseline and at 12 weeks. Protein supplementation alone failed to improve physical performance. However, when combined with light exercise, there was significant improvement in some (6-minute walk, 10 m walking speed, quadriceps strength), but not all, physical function measurements. The results of this pilot study suggest that further exploration of potential interactive effects between protein supplementation and light exercise in individuals with HFpEF is warranted.
World Christianity and Mission 2021: Questions about the Future
Authors: Zurlo Gina A. , Johnson Todd M. , Crossing Peter F.
Published: December 2020

This article marks the thirty-seventh year of including statistical information on World Christianity and mission in the International Bulletin of Mission Research. This year it includes details on some of the most frequently asked questions in quantifying mission and global Christianity: the number of missionaries worldwide, global access to the gospel, and the burgeoning Pentecostal/Charismatic movement. The article also provides brief methodological reflections on how the future of this kind of research might change, given the realities of COVID-19.
Impact of bedaquiline on treatment outcomes of multidrug-resistant tuberculosis in a high-burden country
Authors: Chesov Dumitru , Heyckendorf Jan , Alexandru Sofia , Donica Ana , Chesov Elena , Reimann Maja , Crudu Valeriu , Botnaru Victor , Lange Christoph
Published: December 2020

Background

Evaluation of novel anti-tuberculosis (TB) drugs for the treatment of multidrug-resistant (MDR)-TB continues to be of high interest on the TB research agenda. We assessed treatment outcomes in patients with pulmonary MDR-TB who received bedaquiline-containing treatment regimens in the Republic of Moldova, a high-burden MDR-TB country.

Method

We systematically analysed the SIMETB national electronic TB database and performed a retrospective propensity score-matched comparison of treatment outcomes in a cohort of patients with MDR-TB who started treatment during 2016–2018 with a bedaquiline-containing regimen (bedaquiline cohort) and a cohort of patients treated without bedaquiline (non-bedaquiline cohort).

Results

Following propensity score matching, 114 patients were assigned to each cohort of MDR-TB patients. Patients in the bedaquiline cohort had a higher 6-month sputum culture conversion rate than those in the non-bedaquiline cohort (66.7%versus40.3%; p<0.001). Patients under bedaquiline-containing regimens had a higher cure rate assessed by both World Health Organization (WHO) and TBnet definitions (55.3%versus24.6%; p=0.001 and 43.5%versus19.6%; p=0.004, respectively), as well as a lower mortality rate (8.8%versus20.2%; p<0.001 and 10.9%versus25.2%; p=0.01, respectively). In patients who previously failed on MDR-TB treatment, >40% of patients achieved a cure with a bedaquiline-containing regimen.

Conclusions

Bedaquiline-based MDR-TB treatment regimens result in better disease resolution when compared with bedaquiline-sparing MDR-TB treatment regimens under programmatic conditions in a country with a high burden of MDR-TB.
Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: machine learning on proteomics from the DETECT cohort
Authors: Bauer Yasmina , de Bernard Simon , Hickey Peter , Ballard Karri , Cruz Jeremy , Cornelisse Peter , Chadha-Boreham Harbajan , Distler Oliver , Rosenberg Daniel , Doelberg Martin , Roux Sebastien , Nayler Oliver , Lawrie Allan
Published: December 2020

Pulmonary arterial hypertension (PAH) is a devastating complication of systemic sclerosis (SSc). Screening for PAH in SSc has increased detection, allowed early treatment for PAH and improved patient outcomes. Blood-based biomarkers that reliably identify SSc patients at risk of PAH, or with early disease, would significantly improve screening, potentially leading to improved survival, and provide novel mechanistic insights into early disease. The main objective of this study was to identify a proteomic biomarker signature that could discriminate SSc patients with and without PAH using a machine learning approach and to validate the findings in an external cohort.

Serum samples from patients with SSc and PAH (n=77) and SSc without pulmonary hypertension (non-PH) (n=80) were randomly selected from the clinical DETECT study and underwent proteomic screening using the Myriad RBM Discovery platform consisting of 313 proteins. Samples from an independent validation SSc cohort (PAH n=22 and non-PH n=22) were obtained from the University of Sheffield (Sheffield, UK).

Random forest analysis identified a novel panel of eight proteins, comprising collagen IV, endostatin, insulin-like growth factor binding protein (IGFBP)-2, IGFBP-7, matrix metallopeptidase-2, neuropilin-1, N-terminal pro-brain natriuretic peptide and RAGE (receptor for advanced glycation end products), that discriminated PAH from non-PH in SSc patients in the DETECT Discovery Cohort (average area under the receiver operating characteristic curve 0.741, 65.1% sensitivity/69.0% specificity), which was reproduced in the Sheffield Confirmatory Cohort (81.1% accuracy, 77.3% sensitivity/86.5% specificity).

This novel eight-protein biomarker panel has the potential to improve early detection of PAH in SSc patients and may provide novel insights into the pathogenesis of PAH in the context of SSc.