bluuebunny/crossref_metadata_2025 huggingface dataset:
Fe₃O₄@Polydiallyl Isophthalate Magnetic Microspheres for Enhanced MRI/CT and Magnetothermal Effect-Guided Tumor Ablation
Authors: Chen Piaoyi , Zhou Yanfang , Chen Mianrong , Lun Yingying , Li Qiuxia , Xiao Qinglin , Huang Yugang , Li Jiesong , Ye Guodong
Published: April 2022

Background: Multi-functional embolic microspheres for treating stage B hepatocellar carcinoma often require complex synthesis processes and harsh conditions. But the traditional embolic agents (e.g. polyvinyl alcohol and iodized oil) often cause unexpected embolism and have potential risks of damaging the human body. The aim of this research was to use a photo-click method to prepare multifunctional microspheres with magnetocaloric effect and MR/CT/DSA imaging function used in the transcatheter arterial embolization.Methods: Fe3O4@polydiallyl isophthalate (Fe3O4@PDAIP) magnetic microspheres were synthesized by one-pot photopolymerization without hindered by degradative chain transfer. The in vitro and in vivo anti-tumor effects were characterized with hepatoma cell experiments and tumor-bearing mouse model. The DSA and CT in vitro were utilized to evaluate imaging ability of Fe3O4@PDAIP. The safe was tested via histopathological examination and serum detection.Result: The results showed that Fe3O4@PDAIP magnetic microspheres had ablation effect on tumor cells and had imaging effect through MR/CT/DSA scanning. The microspheres was heated to 42-48 oC by magnetocaloric effect in alternating magnetic field, which significantly decreased the activity of mouse liver cancer cells in vitro. In vivo, it can inhibit the growth of tumor after magnetothermal therapy without obvious toxicity.Conclusion: Fe3O4@PDAIP magnetic microspheres can be potentially applied to the locoregional and precise interventional treatment of liver tumors.
Weight loss in elderly orthopaedic patients leads to bone loss
Authors: Chen Xiangxu , Bai Liyong , Tian Chuwei , Zhao Yakuan , Zhang Cheng , Shi Liu , Zhang Yuanwei , Xie Wenjun , Chen Hui , Rui Yunfeng
Published: April 2022

BackgroundThe number of patients with osteoporosis or low bone mass is increasing annually. Weight loss is reportedly associated with bone loss and is a strong predictor of osteoporosis. It was still not clear the relationship between weight loss and bone loss in the elder.MethodsThe study included 520 patients aged ≥65 years (178 men and 342 women). Age, gender, weight, and height were recorded. Femoral neck bone mineral density and T-score were investigated using a dual-energy X-ray absorptiometry scanner. Blood calcium (Ca), phosphorus (P), albumin (ALB), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were measured. Patients were classified by gender (male and female), age (65-79 years and ≥80 years), and T-score: normal, osteopenia and osteoporosis.ResultsAge, gender, body mass index (BMI), ALP and TG were independent factors for osteoporosis. For the 65-79 and ≥80 year age groups, female patients presented lower T-scores than males. Ca, P, ALB, ALP, TC, HDL and LDL levels were significantly different between men and women in the 65-79 year age group. In addition, BMI and TG levels were significantly decreased in osteoporotic patients compared with normal bone mass patients. TC levels declined in 65-79 year-old male and female patients with osteoporosis. In the group of women aged ≥80 years, osteoporotic patients showed significantly increased ALP levels. Furthermore, we found positive correlations between BMI and TG levels in the groups of male and female patients. However, we found no significant differences in ALB, Ca, P, HDL and LDL levels in osteoporotic compared to normal bone mass patients.Conclusion Osteoporotic patients showed significantly decreased BMI and TG levels compared with those with normal bone mass. BMI was showed positive correlations with TG levels in male and female patients. These results indicate a correlation between weight loss and bone loss and a correlation between lipid profiles and bone mass.
Brain Computer Interface using hybrid adaptive filtering and Higher order Crossing Analysis based on Modified DNN
Authors: Sharad Shwetav , Chakraverti Sugandha , Kundu Shakti , Chakraverti Ashish Kumar , Singh Murari Kumar
Published: April 2022

Brain computer interface (BCIs) aims to communicate with external devices and also recognize human activities through brain signals. However, existing algorithms have some drawbacks, such as poor resolution, high-frequency noise, risk, and low accuracy. Various machine learning algorithms have been used to recognize human activities, but it is more complex to recognize the activities of humans. In order to solve these issues BCIs system based on modified DNN is proposed. Using a modified DNN algorithm, all human activities are recognized through the brain signals. The proposed method contains two phases such as training and testing the data. First, the Brain signal is taken as input, and then the next phase is pre-processing. The signal is pre-processed using a bandpass filter to remove noise present in the signal. Then the next phase is feature extraction, for that features are extracted from the pre-processed signal using Hybrid Adaptive Filtering (HAF) and Higher Order Crossing (HOC) analysis. In order to evaluate the HAF-HOC performance on a user-independent basis, a set of brain signals for each human activity was analyzed and pre-processed. The next phase is classification. For classifying the brain signal, a modified DNN algorithm is used. The Sailfish Optimization technique is used to train the neural network and also used to optimize the weights of the DNN classifier. The results show that the proposed method can obtain 98% accuracy and 0.03 Error, and 10% False Positive Rate. An existing system such as SVM, KNN, RF, and NB reached 86%, 90%, 83% and 70% accuracy, respectively, which is lower than our proposed method.
Screening for anti-neoplastic enzymes producing halophilic bacterial extract and their antioxidant activity due to carotenoid synthesis
Authors: Rathakrishnan Deepalaxmi , Gopalan Arunkumar
Published: April 2022

Out of 1127 halophilic bacteria, salt-loving microorganisms from different geographical locations in India isolated, twenty-eight strains were studied for antioxidant qualities for its usage in cancer medicines. The methanolic extracts were extracted and analyzed for anti-cancer effect through anti-neoplastic enzymes (L-asparaginase and L-glutaminase) screening, while antioxidant capabilities were investigated for fifteen isolates using both radical and non-radical assays.. The extracts also have enhanced radical scavenging ability against the stable 2,2'azinobis (3-ethylbenzothiazoline-6-sulfonic acid) disodium salt radical cation (86.34±0.007 mM TE/g extract), nitric oxide (64.79±0.004 μg/mL), phosphomolybdenum (1.69±0.024 mg AAE/g extract), ferric reducing power (28.19±0.012 mM Fe (II) E/mg) and showed better Ic50 values on 1,1-diphenyl- 2-picrylhydrazyl (5.48 mg/ml) assay. All of the studies has been done three times, and the results are significantly better than the standards utilized. Finally, four potent halophilic isolates from various antioxidant activities were chosen. These isolates could synthesize carotenoids that possessed anti-oxidant activities when grown in the halophilic medium was identified by UV/Visible spectra analysis. Secondary metabolite investigations using GC-MS study and LC-MS/MS analysis confirmed that isolated strains had the potential to produce compounds that might be used primarily as therapeutics. The enormous anti-oxidant potential of the strains Staphylococcus arlettae, Bacillus subtilis, B. tequilensis, and B. haynesii extracts could be used as a natural free radical scavenger to prevent oxidative-stress-related illnesses like cancer, neurodegeneration, as well as in the food safety markets in general.
Patient’s preferences on the use of Telemedicine during the Coronavirus disease 2019 (COVID-19) Pandemic. ONCOTELEMED study
Authors: Ribera Paula , Soriano Sandra , Climent Carla , Vilà Laia , Macias Ismael , Fernandez Luis , Giner Julia , Gallardo Enrique , Seguí Miquel Àngel , Pericay Carles
Published: April 2022

BACKGROUND
Since the beginning of the COVID-19 pandemic, the use of telehealth for cancer care was rapidly implemented without previous experience. Afterwards, few published studies have assessed patient’s perception with the use of telemedicine during this period. The main objective of ONCOTELEMD study was to evaluate the opinion of patients attended via telemedicine during the first quarter of 2020 in the Medical Oncology Service of Hospital Parc Taulí, Sabadell.
METHODS
646 patients were visited via telephone between March 13 and April 30 2020. A 12-question survey was presented to them between February 4 and April 19 2021. Statistical analysis was carried out using Chi-square test.
RESULTS
487 patients responded. Median age was 68 years [27–90]. 90% of patients were satisfied with the telephone visit and 60% would agree to switch some in-person to virtual visits in the future. In general, patients agreed to be informed via telehealth of radiological/analytical results but not of new oral or endovenous treatments. 75% of patients had a medium or low-null knowledge of new technologies. However, statistical significant differences were found according to age groups. 60% of patients younger than 50 years would prefer to have different technological tools to contact their oncologist whereas 58% of patients older than 70 years would prefer only telephone or video-calls.
CONCLUSIONS
In global, patients surveyed were satisfied with the virtual visit and believe that telehealth could have a role following COVID-19 pandemic. Nevertheless, it is necessary to individualize its use according to patient’s preferences and conditions.
Genome wide association study of grain hardness and novel Puroindoline alleles in common wheat
Authors: Wang Junyou , Yang Chenkang , Zhao Wenjia , Wang Ying , Qiao Ling , Wu Bangbang , Zhao Jiajia , Zheng Xingwei , Wang Juanlin , Zheng Jun
Published: April 2022

Grain hardness is a key determinant of wheat milling and end-use quality. Puroindoline genes (PINs) are the major genes responsible for wheat grain hardness, but other QTLs also contribute to this trait. Therefore, it is essential to identify loci associated with grain hardness and to the better describe the diversity of PINs in wheat. In this study, 287 wheat accessions representing 70 years of Shanxi Province wheat breeding were used to study grain hardness. Genome-wide association analysis (GWAS) was performed using the 15 K array, and the diversity of PIN alleles was investigated. Among the accessions there was a continuous distribution for grain hardness index (HI) with hard wheat being most common. GWAS identified nine significant marker-trait associations (MTAs), including that located on PINs, which explained 7.03–17.70% of phenotypic variation. Four MTAs on chromosome 2A, 2B, 5A, and 7A were novel loci. A total of 11 PIN alleles were detected, including a novel double-deletion allele of PIN genotype in Donghei1206. The most frequent genotypes were Pina-Dla/Pinb-Dlb (43.9%) and Pina-Dla/Pinb-Dip (18.8%), and both the frequency of Pina-D1a/Pinb-D1b and the HI value increased with breeding years. These results improve understanding of the genetics of grain hardness and help future molecular marker-assisted breeding for this important trait.
Trypanosoma cruzi antigenic proteins, shared with acute lymphoblastic leukemia and neuroblastoma
Authors: García Leticia Eligio , Guerrero Mariana Soria , Vázquez María del Pilar Crisóstomo , Acosta Víctor Alberto Maravelez , Campos Adrián Cortés , Jimenez Enedina
Published: April 2022

An inhibitory relationship has been reported between the incidence of some parasitic infections and the development of cancer. Some studies indicate that immunization with protein extracts of T.cruzi, the protozoan parasite that causes Chagas disease, prevents the appearance of tumors in 60% of mice injected with the murine lung carcinoma tumor line. The molecular bases of this process have not been elucidated, although the presence of some antigens present in tumor cells and on the surface of T.cruzi suggests an anti-parasitic immune response with an effective cross-reaction against cancer cells, hence the importance to identify the antigens involved and determine their potential as target cells in anticancer therapy. The general objective of this work is to determine the presence of antigenic proteins of T.cruzi, shared with cells in culture of ALL and NB, for this, polyclonal antibodies against T.cruzi were developed in rabbits, and the reactivity with protein extracts of cultured ALL and NB cells was determined, Likewise, the protein immunodetection of the different strains of T.cruzi was carried out with the anti-T.cruzi antibodies of the five strains. The study would also contribute to broadening the knowledge of immunological interactions between cancer and parasites in the future and therefore would broaden the panorama of new therapeutic strategies applied in oncology.
The Effect of Arterial Cannula Tip Position on Differential Hypoxia During Venoarterial Extracorporeal Membrane Oxygenation
Authors: Wickramarachchi Avishka , Burrell Aidan J.C. , Stephens Andrew F. , Šeman Michael , Vatani Ashkan , Khamooshi Mehrdad , Raman Jaishankar , Bellomo Rinaldo , Gregory Shaun D.
Published: April 2022

Background: The interaction between native left ventricular output and venoarterial extracorporeal membrane oxygenation (VA ECMO) flow may hinder perfusion of oxygenated blood to the aortic arch branches, resulting in differential hypoxia. Typically, the arterial cannula tip is placed in the iliac artery or abdominal aorta. However, the hemodynamics of an advanced arterial cannula tip have not been studied before. This simulation study aimed to investigate the effect of altering arterial cannula tip position on VA ECMO perfusion to the upper extremities.Methods: Computational fluid dynamics simulations were performed using a patient-specific geometry of the aorta and physiologically representative boundary conditions. Four arterial cannula tip positions (P1. common iliac, P2. abdominal aorta, P3. descending aorta and P4. aortic arch) were compared with different degrees of cardiac dysfunction and VA ECMO support (50%, 80% and 90% VA ECMO support).Results: P4 was able to supply oxygenated blood to the arch vessels at all support levels, while P1 to P3 only perfused the arch vessels with the highest level (90%) of VA ECMO support. Even during the highest level of support, P1 to P3 could only provide oxygenated VA ECMO flow at 0.11 L/min to the brachiocephalic artery, compared with 0.5 L/min at P4.Conclusions: Advancing the arterial cannula tip into aortic arch increased the perfusion of blood from VA ECMO to the aortic arch vessels at all simulated support levels. In contrast, the tip position used in standard clinical practice was predicted to result in differential hypoxia during 50% and 80% support with only a slight improvement at 90% support. Therefore, during VA ECMO, advancing the arterial cannula tip has the potential to improve upper body perfusion and reduce the risk of differential hypoxia.
CircCARM1 governs the miR-338-3p/TRAF3 axis to activate the IkBα/P65 signaling pathway, thus contributing to OGD/R-induced AC16 cell injuries
Authors: Yin Xuejiao , Chen Hongdan , Sun Guowei , Xu Yangxing , Wang Lingnan
Published: April 2022

Background: Myocardial cell injury is a key event in acute myocardial infarction (AMI). The involvement of circular RNA (circRNA) in cardiovascular disease has aroused much attention. The purpose of this study was to uncover the role of circRNA coactivator-associated arginine methyltransferase 1 (circCARM1) in cell model of AMI.Methods: Myocardial cells (AC16) were subjected to oxygen glucose deprivation/reoxygenation (OGD/R) to induce AMI models. Expression analysis of circCARM1, miR-338-3p and tumor necrosis factor receptor-associated factor 3 (TRAF3) was conducted using Real-time quantitative PCR (RT-qPCR). Cell viability, proliferation and apoptosis were assessed by CCK-8, EdU or flow cytometry assay. Oxidative stress was evaluated according to MDA level and SOD activity using commercial kits and the protein levels of NOX2 and SOD2 using western blot. The release of inflammatory factors was measured using ELISA kits. The predicted binding association between miR-338-3p and circCARM1 or TRAF3 was validated by pull-down assay or dual-luciferase reporter assay.Results: CircCARM1 was overexpressed in OGD/R-treated AC16 cells. OGD/R suppressed AC16 cell viability and proliferation and promoted apoptosis, oxidative stress and inflammation, while circCARM1 knockdown alleviated these injuries. MiR-338-3p was targeted by circCARM1, and miR-338-3p repression reversed the effects of circCARM1 knockdown. In addition, TRAF3 was a downstream target of the circCARM1/miR-338-3p axis, and TRAF3 reintroduction reversed the effects of miR-338-3p overexpression, thus recovering OGD/R-induced AC16 cell injuries. TRAF3 knockdown attenuated the activity of IkBα/P65 signaling pathway via modulating the miR-338-3p/TRAF3 axis in OGD/R-treated AC16 cells.Conclusion: CircCARM1 governed the miR-338-3p/TRAF3 axis to activate the IkBα/P65 signaling pathway, thus contributing to OGD/R-induced AC16 cell injuries.
Impacts of Koka Hydropower Dam on Benthic Macroinvertebrate Assemblages in the Awash River, Ethiopia
Authors: Getachew Melaku , Gebrie Geremew Sahilu , Mulat Worku Legesse , Mereta Seid Tiku , Kelly-Quinn Mary
Published: April 2022

Macroinvertebrate distribution and community structure in lotic water are influenced by a range of natural environmental variables and other anthropogenic factors, particularly related to the construction of dams. Hydropower dams can alter natural flow regimes, sediment transportation, hydrochemical water quality, channel morphology, water temperature, and nutrient cycles and physically obstruct the dispersal and the migration of macroinvertebrates and fish communities. The objective of this study was to evaluate the impacts of the Koka Hydropower Dam on benthic macroinvertebrate assemblage structures. Environmental, hydromorphological, and macroinvertebrate community data were collected along the course of the Awash River in the upper Awash basin. A total of 2305 macroinvertebrates assigned to 11 orders and 41 families were collected from 15 sites in the upstream, midstream, and downstream reaches. Ephemeroptera (32.2%), Diptera (24.6%), and Trichoptera (20.2%) represented 77% of the total abundances.The canonical correspondence analyses, multivariate test, showed that river velocity and phosphate concentration explained the majority of the variation (60%) in macroinvertebrate community structure among the three reaches possibly due to the dam’s impact in addition to other forms of impairment differences between reaches. The water quality categories of the river reach based on the Shannon diversity index at upstream, midstream, and downstream locations were high, moderate, and low, respectively. Based on the macroinvertebrate family-level information, this study found that the water quality degradation was most severe in the downstream reach. Overall, detection of the specific impacts of the dam is complicated by nutrient pollution in the river.
Prediction Model with External Validation for Early Detection of Postoperative Pediatric Chylothorax
Authors: Moza Rohin , NP Melissa Winder , Adamson Gregory T. , Ou Zhining , Presson Angela P. , Vijayarajah Senthuran , Goldstein Stephanie A. , Bailly David K.
Published: April 2022

Background: Earlier diagnosis of chylothorax following pediatric cardiac surgery is associated with decreased duration of chylothorax. Pleural fluid testing is used to diagnosis chylothorax which may delay detection in patients who are not enterally fed at time of chylothorax onset. Our aim was to develop and externally validate a prediction model to detect chylothorax earlier than pleural fluid testing in pediatric patients following cardiac surgery.Methods: A Multivariable logistic regression model was developed to detect chylothorax using a step-wise approach. The model was developed using data from patients <18 years following cardiac surgery from Primary Children’s Hospital, a tertiary-care academic center, between 2017 and 2020. External validation used a contemporary cohort (n=171) from Lucille Packard Children’s Hospital. Results: A total of 763 encounters (735 patients) were analyzed, of which 72 had chylothorax. The final variables selected were chest tube output (CTO) the day after sternal closure (dichotomized at 15.6 mL/kg/day, and as a continuous variable) and delayed sternal closure. The highest odds of chylothorax was associated with CTO on post sternal closure day 1 >15.6mL/kg/day (odds ratio 11.3, 95% CI 6,3, 21.3). The c-statistic for the internal and external validation datasets using the dichotomized CTO variable were 0.78 (95% CI:0.73, 0.82) and 0.84 (95% CI, 0.78, 0.9) and performance improved when using CTO as a continuous variable (OR 0.84, CI: 95% CI 0.80, 0.87) Conclusions: Using the models described, chylothorax after pediatric cardiac surgery may be detected earlier and without reliance on enteral feeds.
Molecular evidences show human papillomavirus type 124 can be trans-species infection in horses
Authors: Tong Panpan , Palidan Nuerlan , Song Xiaozhen , Jia Chenyang , Duan Ruli , Tian Shuyao , Yang Enhui , Pan Juanjuan , Kuang Ling , Jia Erken , Xie Jinxin
Published: April 2022

Human papillomavirus type 124 (HPV124), a member of betapapillomavirus, is associated with viral warts, actinic keratosis, and squamous cell carcinoma incidence in human. No reports of HPV124 infection in mainland China have been reported to date. In a survey of Chinese horses, we detected HPV124 via next-generation sequencing (NGS) in nasal swabs from 42% (39/93) of Thoroughbred horses, 7% (2/30) of the Akhal-Teke horses, and 17/50 aborted fetal lung tissues of Yili mares that were initially found to be negative for equid herpesvirus 1, which indicated the virus can be trans-species infection in different breeding horses, and suggested that this pathogen may potentially contribute to abortion incidence among horses. Further investigation showed that some workers involved in horse farm were positive for HPV124, which strongly suggested that horse-origin HPV124 strain may be transmissible from human workers to horses. Sequence analyses of E6 gene sequences from 18 Chinese HPV124 samples were performed, revealing that the 7 of 18 HPV124 strain identified both horses and human in the present study shared 100% sequence identity with previously published HPV124 isolate. Phylogenetic analyses based on E6 gene sequences in GenBank further revealed that the HPV124 isolate identified herein was closely related to the NJ3900 HPV124 reference strain, clustering together with the established Beta 1 HPV lineage. These results provide first evidence that HPV124 can infect horses, may function as a causative agent for abortions in Yili horses, and come from HPV124-positive humans laboring.
Inferring predictive genetic models and regulatory elements by deep learning of cross-species single-cell gene expression landscapes
Authors: Li Jiaqi , Wang Jingjing , Zhang Peijing , Wang Renying , Mei Yuqing , Sun Zhongyi , Fei Lijiang , Jiang Mengmeng , Ma Lifeng , E Weigao , Chen Haide , Wang Xinru , Fu Yuting , Liu Daiyuan , Wang Xueyi , Li Jingyu , Guo Qile , Liao Yuan , Yu Chengxuan , Jia Danmei , Wu Jian , He Shibo , Liu Huanju , Ma Jun , Lei Kai , Chen Jiming , Han Xiaoping , Guo Guoji
Published: April 2022

Despite extensive efforts to sequence different genomes, genetic models to interpret gene regulation and cell fate decisions are lacking for most species. Here, we performed whole-body single-cell transcriptomic analysis of zebrafish, Drosophila, and earthworm. We then mapped cell landscapes covering eight representative metazoan species to study gene regulation through evolution. With uniformly constructed cross-species datasets, we developed a deep learning-based strategy, Nvwa, to predict gene expression landscapes and decipher cis-regulatory elements (CREs) at the single-cell level. We systematically compared cell type-specific transcription factors (TFs) and CREs to reveal conserved genetic regulation among vertebrates and invertebrates. Our work provides a valuable resource and a novel strategy for studying regulatory language in diverse biological systems.
Einsatz von virtuellen Rundgängen in der Distanz-Laborlehre
Authors: Braun Christoph , Kayali Fares , Moser Thomas
Published: April 2022

Die praktische Laborlehre an der Fachhochschule St. Pölten ist seit Aufkommen der Covid-19-Pandemie von situationsbedingten Problemen betroffen. Zusätzlich zu dem durch einzuhaltende Abstandsregeln entstandenen Platzmangel und erweiterten Zutrittsbeschränkungen zur Benutzung der Labore kommt es zu kurzfristigen Umplanungen bzw. Umstellungen der Lehreinheiten von Präsenz- auf Hybrid- oder Onlinelehre. Aufgrund der eingeschränkten Nutzungsmöglichkeiten der Laborinfrastruktur, startete daher das Projekt Lab4home mit dem Ziel, neue didaktische Szenarien zur Durchführung von Distanz-Laborlehreinheiten zu entwickeln. Dabei steht eine gemeinsame Konzeption von didaktischen Elementen der Vermittlung, Aktivierung und Betreuung im Einklang mit technisch und finanziell realisierbaren Möglichkeiten. Dieser Beitrag soll nun anhand von zwei Praxisbeispielen zeigen, wie aktuelle Virtual-Reality-Technologien in Form von interaktiv aufbereiteten 360°-Bildmaterialien in didaktische Szenarien eingegliedert wurden. Beantwortet wird dabei, welche Entscheidungen es benötigte, um in Anlehnung an bereits erprobte Gestaltungsprinzipien und Theorien diese Technologie in der Online-Laborlehre einzusetzen. Im Einsatz der entwickelten Szenarien zeigten sich dann zuvor nicht bedachte Auswirkungen auf die Lehre und die infrastrukturelle Organisation. In Form von didaktisch geplanten Panoramafotos wurden den Lernenden beispielsweise Inhalte zur 3D-Druck-Technologie aus wenig bekannten Blickwinkeln (Innerhalb eines 3D-Druckers) vermittelt, wobei bereits medientechnische Grundkenntnisse ausreichten, um die Lernmaterialien zu entwickeln. Das erhobene Feedback der Studierenden zeigt, dass die inhaltliche Erweiterung der Distanz-Laborlehre positiv wahrgenommen wird. Die aus der Umsetzung der ersten beiden Praxisanwendungen entstandenen Erkenntnisse dienen nun zur Entwicklung und Durchführung einer weiterführenden Feldstudie.
Welche Merkmale zeigt eine vollimmersive Mehrpersonen-VR-Simulation im Vergleich zum Einsatz von Videokonferenzsoftware in Gruppenarbeitsprozessen?
Authors: Hejna Urszula , Hainke Carolin , Seeling Stefanie , Pfeiffer Thies
Published: April 2022

Der Einsatz von vollimmersiven VR-Lernumgebungen fördert bei Lernenden die individuellen Fähigkeiten und ihr Vorwissen. Konkrete Lerneffekte und Integrationskonzepte sind jedoch noch nicht ausreichend untersucht. Im Rahmen eines vom BMBF geförderten Forschungsprojektes soll mit diesem Beitrag deshalb der Frage nachgegangen werden: Welche didaktisch-gestalterischen sowie kommunikativ-interaktiven Unterschiede zeigen vollimmersive virtuelle Lernumgebungen gegenüber dem Einsatz von Videokonferenzsoftware im Kontext der Gruppenarbeit? Das Ziel ist es, den Einsatz von Multiplayer-VR-Szenarien der Nutzung von Videokonferenztools für Gruppenarbeitsprozesse im Rahmen der Fallarbeit gegenüberzustellen und deren Vor- und Nachteile aufzuzeigen. Die Ergebnisse zeigen, dass sich für Gruppenarbeitsprozesse in beiden Formaten Vor- und Nachteile finden lassen. Die Umsetzung des Konzeptes der Fallarbeit fällt jedoch in beiden Formaten positiv aus. Folglich ist der Erfolg einer Gruppenarbeit von der konzeptionellen Einbindung der Methode in den Lehrkontext abhängig, sodass die Form der Umsetzung vorwiegend Einfluss auf die Performanz nimmt. Zukünftig gilt es, konkrete Implementierungskonzepte für den Einsatz von VR-Anwendungen in der Lehre zu entwickeln und zu erproben.
Maschinelle Gesichtserkennung im öffentlichen Raum
Authors: Braun Binder Nadja , Kunz Eliane , Obrecht Liliane
Published: April 2022

Der Einsatz von maschineller Gesichtserkennung im öffentlichen Raum birgt die Gefahr einer gesellschaftlichen Massenüberwachung. Werden dabei biometrische Daten, die ein Individuum eindeutig identifizieren, genutzt, handelt es sich nach dem neuen Datenschutzgesetz um eine Bearbeitung besonders schützenswerter Personendaten. Die maschinelle Gesichtserkennung ist in der Schweiz regulatorisch kaum umrissen. Dabei sind Überlegungen dazu dringend geboten. Dies ergibt sich einerseits aus der Grundrechtsrelevanz der Thematik, andererseits fordern zivil-gesellschaftliche Organisationen ein entsprechendes Verbot. Auch die geplante EU-Regelung zur künstlichen Intelligenz, in der die Gesichtserkennung enthalten ist, sollte in den Erwägungen berücksichtigt werden. Vor diesem Hintergrund gibt der vorliegende Aufsatz einen Überblick über die im Zusammenhang mit maschineller Gesichtserkennung im öffentlichen Raum auftre-tenden Rechtsfragen und befasst sich mit der Frage der Notwendigkeit eines Verbots oder Moratoriums.

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L’utilisation de la reconnaissance faciale automatique dans l’espace public comporte le risque d’une surveillance de masse de la société. Si des données biométriques identifiant clairement un individu sont utilisées, il s’agit, selon la nou- velle loi sur la protection des données, d’un traitement de données personnelles sensibles. En Suisse, la reconnaissance faciale automatique n’est guère encadrée par la réglementation. Il est pourtant urgent de réfléchir à cette question. Cela résulte, d’une part, de l’importance de cette question en termes de droits fondamentaux et, d’autre part, de la volonté de certaines organisations de la société civile d’interdire une telle utilisation de ces données. La réglementation européenne prévue en matière d’intelligence artificielle, qui inclut la reconnaissance faciale, devrait également être prise en compte dans les réflexions. Dans ce contexte, le présent article donne un aperçu des questions juridiques qui se posent s’agissant de la reconnaissance faciale automatique dans l’espace public et se penche sur la question de la nécessité d’une interdiction ou d’un moratoire.
An inference problem in a mismatched setting: a spin-glass model with Mattis interaction
Authors: Camilli Francesco , Contucci Pierluigi , Mingione Emanuele
Published: April 2022

The Wigner spiked model in a mismatched setting is studied with the finite temperature Statistical Mechanics approach through its representation as a Sherrington-Kirkpatrick model with added Mattis interaction. The exact solution of the model with Ising spins is rigorously proved to be given by a variational principle on two order parameters, the Parisi overlap distribution and the Mattis magnetization. The latter is identified by an ordinary variational principle and turns out to concentrate in the thermodynamic limit. The solution leads to the computation of the Mean Square Error of the mismatched reconstruction. The Gaussian signal distribution case is investigated and the corresponding phase diagram is identified.
A SHOPPERS TALE: THE DIGITAL MARKETING INFLUENCE ON THE BEHAVIOR OF ONLINE SHOPPING USERS, A PHENOMENOLOGY
Authors:   Philippine School Doha, Doha, Qatar., L. Baranao MAEd Elmerson ,   Research Development, Accreditation and Publication Office, PSD, Doha, Qatar.,   Research Capstone Project, PSD, Doha, Qatar., M. Garzo Louisse ,   Philippine School Doha, Doha, Qatar.,   Research Development, Accreditation and Publication Office, PSD, Doha, Qatar.,   Research Capstone Project, PSD, Doha, Qatar., L. Edra Fsheimer ,   Philippine School Doha, Doha, Qatar.,   Research Development, Accreditation and Publication Office, PSD, Doha, Qatar.,   Research Capstone Project, PSD, Doha, Qatar., Vaunne Drey C. Teruel Lord ,   Philippine School Doha, Doha, Qatar.,   Research Development, Accreditation and Publication Office, PSD, Doha, Qatar.,   Research Capstone Project, PSD, Doha, Qatar., E. Balmores Edward ,   Philippine School Doha, Doha, Qatar.,   Research Development, Accreditation and Publication Office, PSD, Doha, Qatar.,   Research Capstone Project, PSD, Doha, Qatar., Dave U. Alvarado John ,   Philippine School Doha, Doha, Qatar.,   Research Development, Accreditation and Publication Office, PSD, Doha, Qatar.,   Research Capstone Project, PSD, Doha, Qatar.
Published: April 2022

Online shopping has significantly transformed the way consumers buy their desired products in this technological era. This study aims to set out the lived experiences of online shoppers who have altered their buying behavior to a more transcended one especially amidst this pandemic. Method: This qualitative paper made use of a phenomenological research design to understand the lived experiences and perceptions of the participants relative to the central question: How do online marketing strategies affect the behavior of customers? Data were gathered using a one-to-one interview that consists of twenty-five developmental questions and were analyzed using an inductive approach in theme development. Results:Four major themes emerged out of the data gathered which are Product Management, Customer Relations, Buyer-Seller Relationship, and Business Gains. Online shoppers behavior was directly influenced by the digital marketing strategies in consideration to the assessed product, trend impact, customer concerns and satisfaction, and the benefits they can get using this online business platform. The study revealed that online shoppers developed skills and characteristics that affect their purchasing behavior relative to the digital marketing strategies. Conclusion: Digital marketing significantly influenced the purchasing behavior of online shopping users who used various strategies as a reflection of their rich lived experiences.Recommendation: Online products and services providers may consider the identified behaviors of online shoppers through responsive digital marketing strategies crucial in promoting and protecting the best interest of the companies and consumers.
LITERACY INTERVENTION FOR THE TRIBE (PROJECT LIFT): HIGHER EDUCATION INSTITUTION EXTENSION PROGRAM FOR INDIGENOUS PEOPLES
Authors:   Associate Professor 1,Camarines Norte State College, Philippines., Mariscotes Abad Eduardo , Jean Villapando-Abad Delma ,   Associate Professor 1, Camarines Norte State College, Philippines.
Published: April 2022

This study introduces Project LIFT, a collaborative Education/ Training/ Advocacy program for Indigenous Peoples known as Manide Tribe in the province. The history of the program is followed by a description citing the program implementation system. It features the holistic, needs- based approach employed by the extension implementers and partner external linkages in reaching out to the target beneficiaries as well as how the program caters the literacy and skill necessities of the adopted tribe .Project LIFT is presented as one of the avenues for the performance of Extension function of the college.
CLINICAL PROFILE AND EVALUATION OF SERUM PROLACTIN LEVEL IN CIRRHOSIS OF LIVER WITH SPECIAL REFERENCE TO CHILD PUGH SCORE
Authors:   Dr Animesh Debnath -PGT Medicine.Jorhat Medical College & Hospital (JMCH)., Animesh Debnath , A.K Sen ,   Dr A.k.Sen -Prof & HOD Department of Medicine (JMCH)., Jawgam Umbon ,   Dr Jawgam Umbon -Associate Professor Department of Medicine (JMCH)., Barhoi Anju Teli ,   Dr Anju Barhoi Teli .Prof & Hod Department of Biochemistry (JMCH ).
Published: April 2022

Clinical profile and evaluation of serum prolactin level in cirrhosis of liver with special reference to Child Pugh Score. Abstract Background: With the increasing incidence of liver cirrhosis the use of a biomarker such as prolactin, indicates the severity of the disease, its complications and serves as a tool for early intervention. Aim: To study the clinical profile and evaluation of serum Prolactin level in Cirrhosis of Liver with special reference to Child Pugh Score. Materials and Methods: A observational cross sectional study on 70 patients admitted under Department of Medicine, JMCH from July 2020 to June 2021. All the patients are subjected to the routine work up for chronic liver disease including serum prolactin level. Results: A total of 70 Patients analyzed in the study. The mean age is found to be 47 years with SD Â±13 years, the male and female ratio is 4:1 with mean prolactin levels among the males, it is 36.9 ng/dl with SD Â±15.3 ng/dl and in females it is 42.8 ng/dl with SD Â±14.2 ng/dl . Of the 70 patients in this study, 59 (84.3%) of them had serum prolactin levels elevated above 19 ng/ml with various clinical profiles . The various clinical presentations noted in our study included ascites in 69 (98.5%) patients, portal hypertension in 63( 90 %) of the patients , oesophageal varices in 44 (62.85%) with upper GI bleed in 31 (44.3%) patients, hepatic encephalopathy (grades 1-4) in 50 (71.42%) patients. Out of 70 patients 55(78.5%) were of class C in child pugh score and the mean prolactin level is found to be 43.638 ng/ml while normal serum prolactin levels is seen in all patients with Class A of Child Pugh Class with p value < 0.001 . The Spearmen coefficient value i.e. the r-value was 0.830 which is a strong positive correlation between the child pugh scoring system and serum prolactin level. Conclusion: Serum prolactin level correlated with the Child Pugh score in predicting the severity of the disease. Patients with a higher serum prolactin have a greater incidence of complications of cirrhosis like PHTN, HE and Esophageal varices.
QUÍMICA VERDE E A TABELA PERIÓDICA DE ANASTAS E ZIMMERMAN: TRADUÇÃO E ALINHAMENTOS COM O DESENVOLVIMENTO SUSTENTÁVEL
Authors: Júnior Carlos , Jesus Dosil , Júnior Gildo
Published: April 2022

GREEN CHEMISTRY AND THE PERIODIC TABLE BY ANASTAS AND ZIMMERMAN: TRANSLATION AND ALIGNMENT WITH A SUSTAINABLE DEVELOPMENT. Green and Sustainable Chemistry (GSC) provides scientific and ethical innovations to achieve a sustainable future. In this context, international efforts and strategies have been made to incorporate this green philosophy into education. Brazil has immense potential to lead in this scenario, providing new approaches to introduce GSC into secondary education, especially with 2022 being the International Year of Basic Sciences for Sustainable Development. However, most published works on GSC are in English, which can be a language barrier for implementing GSC into Portuguese-speaking communities, such as Brazil. From this perspective, this paper aims to present a translation of the “Periodic Table of the Elements of Green and Sustainable Chemistry” by Paul T. Anastas and Julie B. Zimmerman into the Portuguese language. Our systematic translation of the names of the elements into Portuguese followed rigorous semantic and contextual details required for this process. We also identified and recommended some teaching opportunities of this interdisciplinary encyclopedia in alignment with a sustainable future. This green periodic table is a multidisciplinary tool that provides directions for “Systems Thinking in Chemistry Education”. Therefore, we contributed to the standardization and greater discussion of this alternative periodic table for future Portuguese-language publications.
Strategic Analysis of the Development Potential of the Entrepreneurial University of Kuzbas
Authors: Leuhova Maria , Korchagina Irina
Published: April 2022

Introduction. Modern universities must fulfill the so-called “third mission” and become entrepreneurial (University 3.0). To go through this strategic transformation, universities need new theoretical approaches to strategizing. The research objective was to identify the strategic opportunities of creating an entrepreneurial university in the Kemerovo Region, i.e. interests of its stakeholders, mission, strategic priorities, competitive advantages, etc. Study objects and methods. The research featured the Kemerovo State University as the leading university in the region. It relied on the strategizing theory and methodology developed by V.L. Kvint, Foreign Member of the Russian Academy of Science. It involved an analysis of interests and values, an OTSW analysis, the method of strategic priorities and competitive advantages, etc. Results and discussion. The strategic development of the Kemerovo State University as an entrepreneurial university on its way to University 4.0 proved to be possible and expedient. The interests of the main stakeholders coincided in the field of R&D commercialization and the development of the entrepreneurial ecosystem of the university. Global, national, and regional trends determined the potential and expediency of “the third mission” of the Kemerovo State University. The strategizing strengths included a ready-made entrepreneurial training system, innovative infrastructure, competencies, and experience in start-ups, while the low level of entrepreneurial culture appeared to be the most obvious weakness. The article introduces the mission of the Kemerovo State University as an entrepreneurial university. The authors identified five strategic priorities, four of which demonstrated competitive advantages, as well as clear strategic contours and goals. Conclusion. The study can be of interest to management departments of universities that plan their strategic development as entrepreneurial universities.
The Role of Strategic Management in Organization Development
Authors: Kocherbaeva Aynura , Samaybekova Zeynegul
Published: April 2022

Strategic management allows business to respond to the changes that occur in the markets, science, technology, economy, society, and politics. Poor strategic management puts the organization at risks and deprives it of the ability to predict and make plans, thus dooming it to short-term, on-the-spur-of-the-moment, or belated decisions. In a highly competitive and dynamic environment, organizations must develop a long-term strategy in order to keep pace with the external changes. In practice, many organizations act as if the environment were permanent, and lose competitive advantage. To be a market leader, the company should be able to predict external changes, design a proper strategy, determine competitive advantages, and avoid strategic risks. Strategy development is unique for each organization and depends on its market position, developmental rate, potential, competitors, products and services, the current state of economy, cultural environment, etc. This research featured the case of mobile provider “O!” (OsOO NUR Telecom, Kyrgyzstan).
Using solar photovoltaic energy in urban water supply systems: a case study in Kayseri, Turkey
Authors: Sekmen Ufuk , Yildiz Omer Faruk , Yilmaz Mehmet , Ozdemir Ozgur
Published: April 2022

Submersible pumps, widely used in deep wells drilled to meet the water needs of users in urban areas, add an additional load to the conventional electricity grid infrastructure and are responsible for increasing the concentration of greenhouse gas emissions in the atmosphere. The main objective of this study is to investigate the technical and economic feasibility of using solar photovoltaic (PV) energy to reduce the net power drawn from the grid by submersible pumps in urban water supply systems. The Germiraltı catchment area (Kayseri, Turkey), which provides all of its energy needs from the city electricity grid, was chosen as the research area. Two different scenarios, ‘hybrid-powered water pumping system’ and ‘grid-connected PV system’, were analyzed and evaluated. A 1,620 kWp grid-connected PV system can inject 2,787.8 MWh/year of energy into the grid, which is more than the total annual energy need of the submersible pumps. The system operates with 85.7% performance ratio (PR), 19.6% capacity factor (CF) and 4.71 (h/d) final yield. The payback period of the system is calculated as 4.1 years. The results show that it is economically competitive to meet the energy needs of submersible pumps in urban water supply systems with solar PV energy.
River flow modelling for flood prediction using artificial neural network in ungauged Perkerra catchment, Baringo County, Kenya
Authors: Chebii Sally Jeruto , Mukolwe Micah Mukungu , Ong'or Basil Iro
Published: April 2022

Artificial neural network (ANN) modelling has been applied successfully in hydrology to predict future flows based on previous rainfall-runoff values. For a long time, flooding has been experienced in the surrounding areas of the Rift Valley lakes including Lake Baringo, fed by the River Perkerra, due to the rising water levels because of the above-normal rainfall season, resulting in massive socioeconomic losses. The study aims at predicting the occurrence of floods in River Perkerra using an ANN model with the input data being 417 consistent pairs of daily rainfall and discharge, and simulated runoff as the output. The model was trained, tested and validated producing a best fit regression with R2 of 0.951 for training, 0.938 for validation, 0.953 for testing giving an average of 0.949 indicating a close relationship between the input and output values. The overall best validation performance, RMSE, was 0.9204 m3/s indicating high efficiency of the FFNN model developed to predict floods. Flows greater than 14 m3/s, Q1, were the extreme flood events closely associated with socioeconomic losses. This prediction of Q1 value is crucial in the formulation and implementation of measures and policies by the County Government that will mitigate adverse impacts of predicted floods in the catchment.
Aggregation of Fe2O3 nanoparticle in the presence of organophosphate esters (OPEs)
Authors: Zhang Yucheng , Shi Yongfeng , Su Xiaotong , Tam Nora F. Y. , Lei Huifang , Chen Zihui , Wu Qihang
Published: April 2022

Aggregation is a key process for determining the environmental behavior and impact of a nanoparticle (NP). Since organophosphate esters (OPEs), which are recognized as emerging contaminants, are distributed widely in the natural aquatic environment, they may contribute to interacting with NPs and ultimately influence their transport and fate. Here, we investigated two typical organophosphate esters OPEs on aggregation the Fe2O3 NP in aquatic environments. The results showed that both tri-ethylhexyl phosphate (TEHP) and tris (chloroisopropyl) phosphate (TCPP) improved the colloidal stability of Fe2O3 NP in artificial water and environmental matrices. TEHP exhibited an obvious effect than TCPP on the Zeta potential and aggregation rates of Fe2O3 NP in artificial water. In the presence of electrolyte, 10 mg/L TCPP and TEHP increased the critical coagulation concentration (CCC) by 3.6 times and 17.4 times, respectively. Compared with pore-water, the aggregation rates of Fe2O3 NP in river water were slightly higher than those in pore-water, which can be attributed to the higher DOC in pore-water. We suggested that the high hydrophobicity and molecular weight of OPEs were considered important factors against the aggregation of Fe2O3 NP in water. Greater surface charge and steric hindrance originating from TCPP and TEHP dominated the colloidal stability of Fe2O3 NP.