bluuebunny/crossref_metadata_2025 huggingface dataset:
Bacteriological Profile and Predictors of Death Among Neonates With Blood Culture-Proven Sepsis in a National Hospital in Tanzania—A Retrospective Cohort Study
Authors: Ba-alwi Nour Abdallah , Aremu John Ogooluwa , Ntim Michael , Takam Russel , Msuya Mwanaidi Amiri , Nassor Hamid , Ji Hong
Published: April 2022

Background

Neonatal sepsis is still a major cause of death and morbidity in newborns all over the world. Despite substantial developments in diagnosis, treatments, and prevention strategies, sepsis remains a common problem in clinical practice, particularly in low-resource countries.

Methods

A retrospective cohort study of 238 neonates with positive blood culture-proven sepsis (in Muhimbili National Hospital) was conducted from January 2019 to December 2020. The outcomes of hospitalization were survival and death.

Results

In total, 45.4% mortality resulted from 238 neonates who had sepsis exclusively based on blood culture positivity. A significant association was found between very low birth weight (VLBW), hyperglycemia, mechanical ventilation, and high neonatal mortality. Among the different clinical presentations of neonatal sepsis, lethargy, vomiting, and respiratory distress were found to be frequently associated with neonatal mortality. Furthermore, sepsis with Gram-negative bacteria and early-onset sepsis were also associated with high neonatal mortality. Of the 108 neonatal deaths, the largest proportion (40%) was observed with Staphylococcus aureus, and the remaining 38% was caused by Klebsiella, 14% by Escherichia coli, 5% by Pseudomonas, 4% by Acinetobacter, and 2% by Streptococcus. No neonatal deaths from Serratia infection were observed. The overall resistance of isolated organisms to the recommended first-line antibiotics was 84% for ampicillin and 71.3% for gentamicin. The resistance pattern for the recommended second-line antibiotics was 76.2% for ceftriaxone, 35.9% for vancomycin, and 17.5% for amikacin.

Conclusion

VLBW, early-onset sepsis, clinical and laboratory parameters like lethargy, vomiting, and hyperglycemia, sepsis with Gram-negative bacteria, and being on mechanical ventilation are strong predictors of death in neonatal sepsis. In addition, this study discovered extraordinarily high resistance to conventional antibiotics. These findings give light on the crucial aspects to consider in preventing this disease and poor outcomes.
Social Media Interventions Strengthened COVID-19 Immunization Campaign
Authors: Di Mauro Antonio , Di Mauro Federica , De Nitto Sara , Rizzo Letizia , Greco Chiara , Stefanizzi Pasquale , Tafuri Silvio , Baldassarre Maria Elisabetta , Laforgia Nicola
Published: April 2022

Background

Since The Italian Medicines Agency (AIFA) has recommended the COVID-19 vaccine Comirnaty in children aged 5–11, the immunization campaign faced vaccine hesitancy in parents. Social media are emerging as leading information source that could play a significant role to counteract vaccine hesitancy, influencing parents' opinions and perceptions. Our aim was to evaluate the coverage of the COVID-19 vaccine Comirnaty in a cohort of children aged 5–11 whose families have been counseled to use Social Media to counteract vaccine hesitancy.

Methods

All parents of children aged 5–11 in a primary care setting were instructed by their pediatrician to get accurate information about the COVID-19 vaccine from a Facebook page. Active calls to vaccinate children were also scheduled through messaging services Pediatotem and Whatsapp. Vaccination rates of children in the study were assessed with an electronic database and compared to both regional and national child vaccination rates.

Results

Coverage of 277 children aged 5–11 was analyzed from 16 December 2021 to 31 January 2022. A total of 62.4% (173/277) of enrolled children received the 1st dose of COVID-19 vaccine Comirnaty and 39.7% (110/277) the 2nd dose. Coverage rates were higher compared both to the regional population (1st dose: 48.8%, 2nd dose: 24.6%; p = 0.001) and national population (1st dose: 32.1%, 2nd dose: 13.8%; p < 0.001).

Conclusion

Increasing vaccine confidence using Social Media interventions have a positive impact on vaccination acceptance of parents.
Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes
Authors: Kapelemera Alinafe Magret , Uang Yow-Shieng , Wang Li-Hsuan , Wu Tien-Yuan , Lee Fang-Yu , Tai Li , Wang Ching-Chiung , Lee Chia-Jung
Published: April 2022

Paclitaxel is a prescribed anticancer drug used to treat various cancers. It is a substrate of cytochrome P-450 (CYP-450) enzymes. Despite its efficacy, paclitaxel has severe side effects. Herbal medicines are commonly used to treat the side effects of chemotherapy. They can be administered before, during, and after chemotherapy. Xiang-Sha-Liu-Jun-Zi Tang (XSLJZT) is a herbal formula commonly used in breast cancer patients. The main purpose of this study was to assess the pharmacokinetic (PK) influence of XSLJZT on paclitaxel PK parameters, determine its effect on CYP-450 enzyme expression, and evaluate its effect on enzyme activity. Sprague Dawley rats were classified into pretreatment and co-treatment groups, where XSLJZT was pre-administered for 3, 5, and 7 days and co-administered 2 h before paclitaxel administration. The rat liver tissues and Hep-G2 cells were used to determine the effects of XSLJZT on CYP3A1/2 and CYP3A4 enzymes respectively. Western blot analysis was used to detect changes in the CYP3A1/2 and CYP3A4 enzymes expression. The influence of XSLJZT on enzyme activity was evaluated using human liver microsomes, and a liquid chromatography-tandem mass spectrometric system was developed to monitor paclitaxel levels in rat plasma. Results demonstrated that XSLJZT increased the area under the concentration versus time curve (AUC) for paclitaxel in pretreatment groups by 2-, 3-, and 4-fold after 3, 5, and 7 days, respectively. In contrast, no significant change in the AUC was observed in the co-treatment group. However, the half-life was prolonged in all groups from 17.11 min to a maximum of 37.56 min. XSLJZT inhibited CYP3A1/2 expression in the rat liver tissues and CYP3A4 enzymes in Hep-G2 cells in a time-dependent manner, with the highest inhibition observed after 7 days of pretreatment in rat liver tissues. In the enzyme kinetics study, XSLJZT inhibited enzyme activity in a competitive dose-dependent manner. In conclusion, there is a potential interaction between XSLJZT and paclitaxel at different co-treatment and pretreatment time points.
Synthesis, Characterization, Biological Activity and Molecular Docking Studies of Novel Organotin(IV) Carboxylates
Authors: Muhammad Niaz , Ahmad Mukhtar , Sirajuddin Muhammad , Ali Zafar , Tumanov Nikolay , Wouters Johan , Chafik Abdelbasset , Solak Kübra , Mavi Ahmet , Muhammad Shabbir , Shujah Shaukat , Ali Saqib , Al-Sehemi Abdullah G.
Published: April 2022

Four new carboxylates complexes with general formula R2SnL2 and R3SnL, where R = n-butyl (1, 3), methyl (2, 4) and L = 4-Chlorophenoxyacetate, were synthesized in significant yields. FT-IR analysis revealed a chelating (1 and 2) and a bridging bidentate (3 and 4) coordination modes for the carboxylate ligand in solid state which was further confirmed by the single crystal X-ray analysis of complex 4. The NMR data (1H, 13C and 119Sn) revealed a higher coordination number around the tin center in R2SnL2 (1 and 2) compared to R3SnL (3 and 4). A close matching was observed between the experimental and calculated structures (obtained at B3LYP/6-31G* + LANL2DZ basis set). Quantum chemical analysis indicates that the carboxylate moiety has the major contribution in the formation of filled and unfilled orbitals as well as in ligand to ligand intramolecular charge transfer during the electronic transitions. The cytotoxicity data of the screened compounds evaluated against lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) revealed that 1, 3 and 4 have shown dose dependent cytotoxic effects while HL and 2 have shown steady and low cytotoxic activities. The antibacterial activity of complexes 1–4 is higher than that of HL. Molecular docking study showed an intercalation binding mode for complex 3 with DNA (docking score = −3.6005) involving four polar interactions. Complex 3 docking with tubulin (PDB ID 1SA0) with colchicine as a target protein resulted in three polar interactions (docking score −5.2957). Further, the docking analysis of the HL and 1–4 has shown an adequate interactions with the coronavirus SARS-CoV-2 spike protein, nucleocapsid protein and human angiotensin converting enzyme (ACE2).
Active Tumor-Targeting Nano-formulations Containing Simvastatin and Doxorubicin Inhibit Melanoma Growth and Angiogenesis
Authors: Negrea Giorgiana , Rauca Valentin-Florian , Meszaros Marta Szilvia , Patras Laura , Luput Lavinia , Licarete Emilia , Toma Vlad-Alexandru , Porfire Alina , Muntean Dana , Sesarman Alina , Banciu Manuela
Published: April 2022

Primary melanoma aggressiveness is determined by rapid selection and growth of cellular clones resistant to conventional treatments, resulting in metastasis and recurrence. In addition, a reprogrammed tumor-immune microenvironment supports melanoma progression and response to therapy. There is an urgent need to develop selective and specific drug delivery strategies for modulating the interaction between cancer cells and immune cells within the tumor microenvironment. This study proposes a novel combination therapy consisting of sequential administration of simvastatin incorporated in IL-13-functionalized long-circulating liposomes (IL-13-LCL-SIM) and doxorubicin encapsulated into PEG-coated extracellular vesicles (PEG-EV-DOX) to selectively target both tumor-associated macrophages and melanoma cells. To this end, IL-13 was conjugated to LCL-SIM which was obtained via the lipid film hydration method. EVs enriched from melanoma cells were passively loaded with doxorubicin. The cellular uptake of rhodamine-tagged nano-particles and the antiproliferative potential of the treatments by using the ELISA BrdU-colorimetric immunoassay were investigated in vitro. Subsequently, the therapeutic agents were administered i.v in B16.F10 melanoma-bearing mice, and tumor size was monitored during treatment. The molecular mechanisms of antitumor activity were investigated using angiogenic and inflammatory protein arrays and western blot analysis of invasion (HIF-1) and apoptosis markers (Bcl-xL and Bax). Quantification of oxidative stress marker malondialdehyde (MDA) was determined by HPLC. Immunohistochemical staining of angiogenic markers CD31 and VEGF and of pan-macrophage marker F4/80 was performed to validate our findings. The in vitro data showed that IL-13-functionalized LCL were preferentially taken up by tumor-associated macrophages and indicated that sequential administration of IL-13-LCL-SIM and PEG-EV-DOX had the strongest antiproliferative effect on tumor cells co-cultured with tumor-associated macrophages (TAMs). Accordingly, strong inhibition of tumor growth in the group treated with the sequential combination therapy was reported in vivo. Our data suggested that the antitumor action of the combined treatment was exerted through strong inhibition of several pro-angiogenic factors (VEGF, bFGF, and CD31) and oxidative stress-induced upregulation of pro-apoptotic protein Bax. This novel drug delivery strategy based on combined active targeting of both cancer cells and immune cells was able to induce a potent antitumor effect by disruption of the reciprocal interactions between TAMs and melanoma cells.
Genetic and Physiological Responses to Heat Stress in Brassica napus
Authors: Kourani Mariam , Mohareb Fady , Rezwan Faisal I. , Anastasiadi Maria , Hammond John P.
Published: April 2022

Given the current rise in global temperatures, heat stress has become a major abiotic challenge affecting the growth and development of various crops and reducing their productivity. Brassica napus, the second largest source of vegetable oil worldwide, experiences a drastic reduction in seed yield and quality in response to heat. This review outlines the latest research that explores the genetic and physiological impact of heat stress on different developmental stages of B. napus with a special attention to the reproductive stages of floral progression, organogenesis, and post flowering. Several studies have shown that extreme temperature fluctuations during these crucial periods have detrimental effects on the plant and often leading to impaired growth and reduced seed production. The underlying mechanisms of heat stress adaptations and associated key regulatory genes are discussed. Furthermore, an overview and the implications of the polyploidy nature of B. napus and the regulatory role of alternative splicing in forming a priming-induced heat-stress memory are presented. New insights into the dynamics of epigenetic modifications during heat stress are discussed. Interestingly, while such studies are scarce in B. napus, opposite trends in expression of key genetic and epigenetic components have been identified in different species and in cultivars within the same species under various abiotic stresses, suggesting a complex role of these genes and their regulation in heat stress tolerance mechanisms. Additionally, omics-based studies are discussed with emphasis on the transcriptome, proteome and metabolome of B. napus, to gain a systems level understanding of how heat stress alters its yield and quality traits. The combination of omics approaches has revealed crucial interactions and regulatory networks taking part in the complex machinery of heat stress tolerance. We identify key knowledge gaps regarding the impact of heat stress on B. napus during its yield determining reproductive stages, where in-depth analysis of this subject is still needed. A deeper knowledge of heat stress response components and mechanisms in tissue specific models would serve as a stepping-stone to gaining insights into the regulation of thermotolerance that takes place in this important crop species and support future breeding of heat tolerant crops.
Application of Dance Movement Therapy to Life-Death Education of College Students Under Educational Psychology
Authors: Yang Liu , Li Fen
Published: April 2022

The present work aims to efficiently carry out life-death education (LDE) for college students, improve their psychological problems, and reduce suicide accidents by combining LDE with Dance Movement Therapy (DMT). DMT is a psychosomatic cross therapy that treats mental or physical diseases through dance or improvisation. Firstly, this paper introduces LDE and DMT and designs the activities of DMT intervention. Secondly, the relationship between DMT and LDE is analyzed. Finally, a questionnaire survey is conducted on the research objects. The research objects are divided into the experimental group receiving DMT intervention, the control group participating in sports dance courses, and the benchmark group. The research data show no significant difference in interpersonal skills and emotional psychology among the three groups. The DMT intervention group has substantial changes in other factors except for the conflict control ability before and after the intervention. In addition, the questionnaire survey results after the intervention demonstrate that the DMT intervention group gets a significantly higher score in the interpersonal relationship, interpersonal relationship building ability, moderate rejection ability, self-disclosure ability, and emotional support ability. Therefore, DMT intervention positively impacts college students’ interpersonal relationships. After the sports dance course, there are differences in the total score of interpersonal ties and scores of interpersonal relationships building ability, self-disclosure ability, and emotional support ability in the control group, but with no significant difference in moderate rejection ability and conflict control ability. Therefore, compared with traditional psychotherapy methods, the DMT method reported here is conducive to releasing pressure and alleviating physical and mental anxiety. The research content provides new ideas for psychological education in colleges and universities and contributes to improving college students’ suicidal tendencies and helping college students grow up healthily.
Chronic Exercise as a Modulator of Cognitive Control: Investigating the Electrophysiological Indices of Performance Monitoring
Authors: Wunder Meaghan L. , Staines W. Richard
Published: April 2022

Exercise may influence components of executive functioning, specifically cognitive control and action monitoring. We aimed to determine whether high level exercise improves the efficacy of cognitive control in response to differing levels of conflict. Fitter individuals were expected to demonstrate enhanced action monitoring and optimal levels of cognitive control in response to changing task demands. Participants were divided into the highly active (HA) or low-active group based on self-reported activity using the International Physical Activity Questionnaire. A modified flanker task was then performed, in which the level of conflict was modulated by distance of distractors from the target (close, far) and congruency of arrows (incongruent, congruent). Electroencephalography (EEG) was collected during 800 trials; trials were 80% congruent, 20% incongruent, 50% close, and 50% far. The error-related negativity (ERN) and error positivity (Pe) were extracted from the difference wave of correct and incorrect response locked epochs, the N2 from the difference wave of congruent and incongruent stimulus locked epochs and the P3 from stimulus locked epochs. The HA group showed a larger Pe amplitude compared to the low-active group. Close trials elicited a larger N2 amplitude than far trials in the HA group, but not the low-active group, the HA group also made fewer errors on far trials than on close trials. Finally, the P3 was smaller in the lowest conflict condition in the HA, but not the low-active group. These findings suggest that habitual, high levels of exercise may influence the endogenous processing involved in pre-response conflict detection and the post-error response.
Understanding the Joint Impacts of Cognitive, Social, and Geographic Proximities on the Performance of Innovation Collaboration Between Knowledge-Intensive Business Services and the Manufacturing Industry: Empirical Evidence From China
Authors: Zhao Ting , Yang Meng , Cao Zhijuan , Wang Xiang
Published: April 2022

Most previous empirical studies just addressed the influence of geographical proximity on interactive learning regarding the collaboration between knowledge-intensive business service (KIBS) and manufacturing industries. Drawing upon the social cognitive and knowledge-based perspective, this study bridged the research gaps by investigating the joint effects of geographical proximity and two representative non-geographic-proximities (i.e., cognitive proximity and social proximity) in fostering manufacturing firms’ innovation performance. In terms of the empirical analysis, we applied a research sample that involves the data of various manufacturing industries in 260 cities of China from 2003 to 2014 to test the corresponding hypotheses. Additionally, the Spatial Durbin Model (SDM) was adopted and the research findings showed that: (i) the geographic and social proximity significantly promote the knowledge transfer from KIBS to manufacturing firms, which further improves the innovation performance of the latter. However, the effect of cognitive proximity presents insignificant; (ii) the interactive effect of geographic and social proximity was positively associated with the innovation collaboration between KIBS and manufacturing firms; (iii) although the individual effect of cognitive proximity was insignificant, when it interacted with geographic or social proximity, the joint effects were proved to promote the innovation performance of manufacturing firms. This study extends our understanding pertaining to the influencing mechanism of proximity for KIBS and the innovation process. The findings proved that geographic and social proximity are two imperative facilitators of knowledge-creating collaboration, highlighting their indispensable role in moderating and mediating the knowledge transfer of KIBS as well as the innovation performance of manufacturing firms. Notably, cognitive proximity is contingent upon geographic and social proximity on its positive effects on the innovation performance for KIBS and their clients’ collaboration.
Psychiatric Hospitalizations of People Found Not Criminally Responsible on Account of Mental Disorder in France: A Ten-Year Retrospective Study (2011–2020)
Authors: Fovet Thomas , Baillet Maëlle , Horn Mathilde , Chan-Chee Christine , Cottencin Olivier , Thomas Pierre , Vaiva Guillaume , D'Hondt Fabien , Amad Ali , Lamer Antoine
Published: April 2022

Background

Criminal responsibility is a key concept in the criminal sanctioning of people diagnosed with mental health disorders who have committed crimes. In France, based on the recommendations of one or more expert psychiatrists, a judge can declare a person not criminally responsible on account of mental disorder (NCRMD) if, at the time of the offense, the person was presenting a psychiatric disorder that abolished or altered his/her capacity for discernment and/or ability to control his/her actions. In such a case, the judge also generally orders an involuntary psychiatric hospitalization. The objectives of this study were to (1) describe longitudinal retrospective administrative data of psychiatric hospitalizations for people found NCRMD, (2) identify the age, sex, and principal diagnoses of these individuals, and (3) characterize the trajectories of their psychiatric care before and after NCRMD psychiatric hospitalization.

Methods

We used discharge reports from the French national hospital database called Programme de médicalisation des systèmes d'information (PMSI) to gather longitudinal data that describe psychiatric hospitalizations for people found NCRMD between 2011 and 2020, the age, sex, and principal diagnoses of these patients, the length of their hospitalization, and the trajectories of their psychiatric care before and after their NCRMD psychiatric hospitalization.

Results

We identified 3,020 patients who were hospitalized for psychiatric care after having been found NCRMD between 2011 and 2020. The number of admissions on these grounds has remained stable over this period, ranging from 263 in 2011 to 227 in 2021. They were mostly young men diagnosed with a psychotic disorder (62%). The majority (87%) were hospitalized in general psychiatric hospitals, and only 13% were admitted to maximum-security units (Unités pour malades difficiles, UMD). The median duration of hospitalization for these patients was 13 months. Our results show that 73% of the patients had already been hospitalized prior to their NRCMD hospitalization. The rehospitalization rate within 5 years of discharge from NCRMD psychiatric hospitalization was 62%.

Conclusion

We conducted the first study investigating the psychiatric hospital treatment of people declared NCRMD in France. There is an urgent need for further studies to investigate the clinical characteristics of these patients.
The Social Connectome – Moving Toward Complexity in the Study of Brain Networks and Their Interactions in Social Cognitive and Affective Neuroscience
Authors: Maliske Lara , Kanske Philipp
Published: April 2022

Over the past 150 years of neuroscientific research, the field has undergone a tremendous evolution. Starting out with lesion-based inference of brain function, functional neuroimaging, introduced in the late 1980s, and increasingly fine-grained and sophisticated methods and analyses now allow us to study the live neural correlates of complex behaviors in individuals and multiple agents simultaneously. Classically, brain-behavior coupling has been studied as an association of a specific area in the brain and a certain behavioral outcome. This has been a crucial first step in understanding brain organization. Social cognitive processes, as well as their neural correlates, have typically been regarded and studied as isolated functions and blobs of neural activation. However, as our understanding of the social brain as an inherently dynamic organ grows, research in the field of social neuroscience is slowly undergoing the necessary evolution from studying individual elements to how these elements interact and their embedding within the overall brain architecture. In this article, we review recent studies that investigate the neural representation of social cognition as interacting, complex, and flexible networks. We discuss studies that identify individual brain networks associated with social affect and cognition, interaction of these networks, and their relevance for disorders of social affect and cognition. This perspective on social cognitive neuroscience can highlight how a more fine-grained understanding of complex network (re-)configurations could improve our understanding of social cognitive deficits in mental disorders such as autism spectrum disorder and schizophrenia, thereby providing new impulses for methods of interventions.
The Myopectineal Orifice: A Study of Thai Cadavers
Authors: Tansawet Amarit , Rodsakan Thanakorn , Kasetsermwiriya Wisit , Lerdsirisopon Sopon , Techapongsatorn Suphakarn
Published: April 2022

Objective

This study aimed to determine the myopectineal orifice size measured in Thai human cadavers.

Materials and Methods

A total of 30 human cadavers, comprising 55 groins, were assessed. Myopectineal orifices (MPOs) were measured in two dimensions: height from the lower border of the conjoined tendon to the upper border of the pectineal ligament and width from the lateral border of pubic tubercle to the medial border of the iliopsoas muscle.

Results

The mean MPO size is 7.13 + 0.14 cm in width and 6.66 + 0.32 m in height. The mean width and height in male cadavers are 7.16 + 0.14 and 6.84 + 0.27 cm, respectively. The mean width and height in female cadavers are 7.09 + 0.12 and 6.45 + 0.24 cm, respectively. The mean MPO area is 37.26 ± 0.027 cm2, compared with the area of mesh graft 10 cm × 15 cm, 150 cm2. Although the shrinkage of cadaveric tissue and mesh size were adjusted, which were 39.56 ± 0.029 and 81 cm2, respectively, they were found to be sufficient for the mean MPO area. It was found that the mesh size was sufficient for the mean MPO area.

Conclusion

A mesh size of 10 cm × 15 cm is found to be the appropriate size to cover the MPO among Thais.
Management Systems for Biannual Seed Crop of Italian Ryegrass (Lolium multiflorum Lam.) Grown at Various Nitrogen Fertilization: II. Second-Production Year Characterized by Considerable Crop Lodging and Limited Seed Shattering before Direct Combine-Harvesting
Authors: Svečnjak Zlatko , Kovačević Martina , Jareš Dario , Týr Štefan , Jama-Rodzeńska Anna , Milanović-Litre Ana
Published: April 2022

Multiyear production of Italian ryegrass seed crop is of interest. The impact of management systems on the second-production year of biannual crop was evaluated at various nitrogen fertilization (0, 60, 120, and 180 kg ha−1). Management systems of single-purpose crops were with (SeedPGR-crop) and without (Seed-crop) plant growth regulator (PGR) application. The dual-purpose crops incorporated early (EF-seed-crop) and late (LF-seed-crop) spring forage cut followed by seed harvest. The Seed-crop obtained a maximum yield (1631 kg ha−1) at 120 kg N ha−1, which decreased by 23% at the highest fertilization. This yield loss was associated with early (before heading) and severe lodging that brought about reduced aboveground biomass and lower harvest index due to the increased growth of vegetative tillers. The single-purpose crops had a similar number of reproductive tillers, seed weight, and seed shed; however, the SeedPGR-crops produced larger yields than the Seed-crops at all fertilization levels indicating the positive impact of PGR application on harvest index regardless of lodging intensity. Despite less lodging and lower seed shattering, the dual-purpose crops yielded less than the single-purpose crops primarily due to the reduction in the number of spikelets per ear and florets per spikelet in various ear sections of early- and late-formed ears. Seed yields of the dual-purpose crops were maximized (around 1200 kg ha−1) at 180 kg N ha−1. The LF-seed-crop had the lightest seeds and the smallest seed germination, but fertilization tended to improve these quality traits. The SeedPGR-crop was the best performing management system yielding above 2200 kg ha−1 at the two highest N levels, allowing greater flexibility in fertilization.
Feeding Habits of Sarda chiliensis chiliensis (Cuvier, 1832) in Northern Chile and Southern Perú
Authors: Pepe-Victoriano Renzo , Aravena-Ambrosetti Héctor , Huanacuni Jordan I. , Méndez-Abarca Felipe , Godoy Karina , Álvarez Nathalia
Published: April 2022

The trophic relationships of pelagic fishes with migratory traits such as the South Pacific Bonito, Sarda chiliensis chiliensis (Cuvier, 1832), have not been studied in depth in the past. The objective of the present research was to analyze the feeding habits of South Pacific Bonito by sex and to analyze a comparison between summer and autumn months in three different areas of the eastern South Pacific by applying different techniques used in trophic biology. Between December 2013 and June 2014, specimens were captured in the areas of Pozo de Lisas (Ilo, Peru), La Capilla (Arica, Chile) and Chanavayita (Iquique, Chile). The feeding dynamics and trophic composition of the diet were analyzed, as well as the feeding strategy and trophic relationships. A total of 1404 specimens were analyzed, of which 654 had stomach contents. Seven prey items were identified: (a) fish remains; (b) squid jaw remains; (c) squid gladius remains; (d) caudal fin remains; (e) Engraulis rigens; (f) Pleuroncodes monodon and (g) N/A (not determined). The Pozo de Lisas and La Capilla areas showed homogeneity in their prey items, while the Chanavayita area showed more diversity. Regarding the importance of prey items in the diet of S. chiliensis in the three localities, it would be correct to state that it is a generalist species.
Comparison of Donkey, Pony, and Horse Dorsal Profiles and Head Shapes Using Geometric Morphometrics
Authors: Maśko Małgorzata , Wierzbicka Małgorzata , Zdrojkowski Łukasz , Jasiński Tomasz , Sikorska Urszula , Pawliński Bartosz , Domino Małgorzata
Published: April 2022

Since donkey breeding has increased due to their variety of uses, welfare evaluation has become more important. This study aimed to compare donkey, pony, and horse dorsal profiles and head shapes using geometric morphometrics (GM). Photographs of 14 donkeys, 14 ponies, and 14 horses were analyzed using GM, including the sliding semilandmarks method. The variations in the first three principal components (PCs) were PC1: 57.16%, PC2: 16.05%, and PC3: 8.31% for the dorsal profiles and PC1: 44.77%, PC2: 13.46%, and PC3: 7.66% for the head shapes. Both the dorsal profiles and head shapes differed between donkeys and horses (p < 0.0001) but not between donkeys and ponies (p > 0.05). Moreover, both the dorsal profiles and head shapes differed in size between ponies and horses (p < 0.0001) but not in shape (p > 0.05). Higher Mahalanobis and Procrustes distances were noted between donkeys and horses as well between donkeys and ponies than between ponies and horses. The use of geometric morphometrics revealed the differences in the dorsal profiles and head shapes between the studied equids. These differences should be taken into account when adapting welfare scales and methods from horses to donkeys.
Effects of Rearing System and Fattening Intensity on the Chemical Composition, Physicochemical Properties and Sensory Attributes of Meat from Young Crossbred (Holstein-Friesian × Hereford) Bulls
Authors: Nogalski Zenon , Pogorzelska-Przybyłek Paulina , Sobczuk-Szul Monika , Modzelewska-Kapituła Monika
Published: April 2022

The study was aimed at determining the effects of the rearing system and intensity of fattening on beef physicochemical properties and sensory quality, fatty acid composition, and mineral compounds and vitamins concentration. The study was conducted using meat from 38 young, crossbred bull calves, which were reared with nurse cows (C) or were fed milk replacer (R). In the study, intensive (Int) or semi-intensive (SInt) fattening system were applied. The bulls were slaughtered at the age of 560 days and samples of the longissimus lumborum (LL) muscle were collected. Meat from C bulls was juicier (p < 0.05) and had a higher concentration of conjugated linoleic acid (CLA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), as well as zinc (Zn), iron (Fe), and α-tocopherol, compared with meat from R bulls. The Int system resulted in the intramuscular fat (IMF) content increase (p < 0.01) and reduced shear force (p < 0.05), compared with the SInt system. Meat from Int bulls had a better eating quality and a higher monounsaturated fatty acid (MUFAs), Zn, and Fe; however, it had a lower proportion of polyunsaturated fatty acids (PUFAs) and α-tocopherol concentration than meat obtained from SInt bulls.
Towards Improved Inertial Navigation by Reducing Errors Using Deep Learning Methodology
Authors: Chen Hua , Taha Tarek M. , Chodavarapu Vamsy P.
Published: April 2022

Autonomous vehicles make use of an Inertial Navigation System (INS) as part of vehicular sensor fusion in many situations including GPS-denied environments such as dense urban places, multi-level parking structures, and areas with thick tree-coverage. The INS unit incorporates an Inertial Measurement Unit (IMU) to process the linear acceleration and angular velocity data to obtain orientation, position, and velocity information using mechanization equations. In this work, we describe a novel deep-learning-based methodology, using Convolutional Neural Networks (CNN), to reduce errors from MEMS IMU sensors. We develop a CNN-based approach that can learn from the responses of a particular inertial sensor while subject to inherent noise errors and provide near real-time error correction. We implement a time-division method to divide the IMU output data into small step sizes to make the IMU outputs fit the input format of the CNN. We optimize the CNN approach for higher performance and lower complexity that would allow its implementation on ultra-low power hardware such as microcontrollers. Our results show that we achieved up to 32.5% error improvement in straight-path motion and up to 38.69% error improvement in oval motion compared with the ground truth. We examined the performance of our CNN approach under various situations with IMUs of various performance grades, IMUs of the same type but different manufactured batch, and controlled, fixed, and uncontrolled vehicle motion paths.
Changes in Selected Properties of Cold-Pressed Oils Induced by Natural Plant Additives
Authors: Krajewska Marta , Kachel Magdalena
Published: April 2022

Cold-pressed oils are becoming increasingly popular. The stability of these oils is the main concern, as changes occur in their organoleptic characteristics during storage, which could affect their suitability for consumption. Various natural plant components with antioxidant properties are added to cold-pressed oils to preserve their freshness for as long as possible. The present study assessed the effect of addition of garlic and chili pepper on the chemical properties of cold-pressed oil extracted from seeds of flax, hemp, and black cumin. First, the moisture level and the fat and protein content in the seeds were determined, and the oil was then extracted. The oil extraction yield was calculated, and the oil was analyzed to determine its fatty acid composition, acid value, peroxide value, and oxidative stability. Three samples were prepared for further analyses: a control sample with pure oil and two samples supplemented with 1 g/100 g of garlic or chili pepper. Changes in the oil samples stored for 2, 4, and 6 weeks were assessed based on the values of some parameters. The additives were found to exert antioxidant properties, as they caused effective inhibition of oxidative changes occurring during storage of the oils. The additives also extended the induction time.
Conventional Cervical Exercises Compared with a Mixed-Reality-Based Game in Asymptomatic Subjects: An Exploratory Crossover Pilot Study
Authors: Diaz-Saez Marta C. , Navarro-Fernández Gonzalo , Fernandez-Carnero Josué , Garrigós-Pedrón Miriam , Romero Muñoz Juan Pablo , Beltran-Alacreu Hector
Published: April 2022

Mixed reality presents itself as a potential technological tool for the management of people with musculoskeletal disorders, without having as many adverse side effects as immersive virtual reality. The objective of this study was to explore the possibilities of a mixed-reality game, performing task-oriented cervical exercises compared to conventional therapeutic exercises in sensorimotor outcome measures in asymptomatic subjects. A randomized crossover pilot study was performed with two intervention groups: a mixed-reality group (MRG) and a conventional exercise group (CEG). The cervical joint position error test (CJPET) and deep cervical flexor endurance test (DCFET) were measured as sensorimotor outcomes. Statistically significant differences were found in the pre–post comparison in the DCFET for both groups (MRG: t = −3.87, p < 0.01; CEG: t = −4.01, p < 0.01) and in the extension of the CJPET for the MRG (t = 3.50, p < 0.01). The rest of the measurements showed no significant differences comparing both groups pre- and postintervention (p > 0.05). Mixed reality has apparently the same positive effects as conventional exercises in sensorimotor outcomes in asymptomatic subjects. These results could help in future studies with mixed virtual reality in the management of people with musculoskeletal disorders.
Alkaline Extraction of Organomineral Potassium Humate from Coal Mining Waste
Authors: Nazarbek Ulzhalgas , Abdurazova Perizat , Nazarbekova Saule , Assylbekova Dina , Kambatyrov Maksat , Raiymbekov Yerkebulan
Published: April 2022

Organomineral potassium humate was extracted from coal mining waste from the Lenger deposit (Turkestan region, Kazakhstan) by alkaline extraction using an aqueous solution of potassium hydroxide. The time and temperature of the process were investigated for the degree of extraction and yield of the product. A comprehensive study of the physicochemical properties of the raw material and the resulting production potassium humate was carried out by chemical analysis, scanning electron microscope, energy dispersion, IR-Fourier spectrometric and X-ray diffractographic analyses. The maximum degree of extraction and yield of the product wasachieved at 80 °C and 90 min. Moreover, the experimental data were subjected to kinetic processing, as a result of which it was established that the process of extraction of potassium humate occurs in the external diffusion region.
Decomposition and Decoupling Analysis between HDI and Carbon Emissions
Authors: Li Dongju , Shen Tongtong , Wei Xi , Li Jie
Published: April 2022

The concept of low carbon is extended to the welfare dimension by considering the relationship between carbon emissions and the Human Development Index (HDI). This paper examines the decoupling between carbon emissions per capita and HDI and the welfare output of carbon emissions by using the data from 189 countries, from 1990 to 2019, as well as decomposes the drivers of the decoupling index and carbon emissions performance (CEP) in the example countries. The results show that most countries that achieve strong decoupling have very high human development, while the worst case is that a few countries with an extremely low human development achieved strong decoupling. Moreover, the status of strong decoupling in most countries is not stable, and there is a risk of transformation to another decoupling status. Although the CEP of most countries has gradually improved, very few countries have high CEP. Economic development effects are the primary inhibitor to achieving and maintaining strong decoupling in example countries. The main drivers of CEP improvement are the carbon productivity effects in the Czech Republic, Germany, and the United Kingdom, and the economic development effects in South Korea and Turkey. The main factors inhibiting the increase of CEP are the energy intensity effect in the Czech Republic, Germany, and the UK, and the welfare effect in South Korea and Turkey. These effects are all related to GDP. Economic activity broadly affects the decoupling index and CEP. Recommendations for maintaining HDI growth and reducing carbon emissions are made for countries with different human development.
Analysis and Prediction of Flow-Induced Vibration of Convection Pipe for 200 t/h D Type Gas Boiler
Authors: Yao Shouguang , Huang Xinyu , Zhang Linglong , Mao Huiyi , Sun Xiaofei
Published: April 2022

This paper is aimed at the analysis and prediction of the fluid-induced vibration phenomenon in the convection tube bundle area caused by Karman vortex street shedding in the background of a 200 t/h large-capacity D-type gas boiler. Based on the numerical simulation of flue heat state flow field and fast Fourier transform, the lift coefficient curve of different monitoring areas and the corresponding Karman vortex street shedding frequency are obtained. The accuracy of the analysis model is validated by comparing Karman vortex shedding frequency with acoustic equipment standing wave frequency. In order to meet the design requirements of the 200 t/h D-type gas boiler for reliable and stable operation, the vibration characteristics and variation rules of a convection tube bundle in a D-type boiler under different working conditions are predicted.
Comparative Assessment of the Functional Parameters for Metal-Ceramic and All-Ceramic Teeth Restorations in Prosthetic Dentistry—A Literature Review
Authors: Ispas Ana , Iosif Laura , Popa Daniela , Negucioiu Marius , Constantiniuc Mariana , Bacali Cecilia , Buduru Smaranda
Published: April 2022

The metal-ceramic fixed partial prosthesis is the golden standard for posterior tooth restorations. Following the demands of patients and clinicians for metal-free restorations, all-ceramic materials were developed as they offer an adequate alternative with better optical qualities and good mechanical properties. This study aims to carry out a bibliographic review to assess the survival rate and the biological and technical complications of all-ceramic and metal-ceramic fixed partial dentures. An electronic search for articles in the English language literature was performed using PubMed (MEDLINE). This literature review focused on research studies between 2010 and 2020 that performed clinical studies on tooth-supported fixed partial dentures with a mean follow-up of at least 3 years. All the studies, which analyzed the survival and complications of tooth-supported fixed partial dentures, were included. Thus, 14 studies reporting on 756 all-ceramic and 160 metal-ceramic fixed partial dentures met the inclusion criteria. A comparative analysis was carried out based on all the data existing in the studies included in this review. The metal-ceramic fixed partial dentures showed survival rates of 95% to 100% at 3-, 5-, and 10-year follow-up periods. Zirconia fixed partial dentures were reported to have survival rates of 81% to 100% at 3-, 5-, 9-, 10-year follow-up evaluations. The reinforced glass-ceramic fixed partial dentures showed survival rates of 70% to 93.35% at 5 years, while the alumina FPDs showed a survival rate of 68% at 3 years follow-up. The incidence of caries and loss of vitality were reported as higher for all-ceramic prostheses as compared to the metal-ceramic ones. A significant framework fracture was reported for glass-infiltrated alumina fixed partial dentures in comparison to metal-ceramic fixed partial dentures. All-ceramic and metal-ceramic restorations showed similar survival rates after 3 years, although all-ceramic restorations have problems with technical complications such as chipping, which can lead to framework fractures over time.
Neural Network-Based Prediction Model for the Stability of Unlined Elliptical Tunnels in Cohesive-Frictional Soils
Authors: Sirimontree Sayan , Keawsawasvong Suraparb , Ngamkhanong Chayut , Seehavong Sorawit , Sangjinda Kongtawan , Jearsiripongkul Thira , Thongchom Chanachai , Nuaklong Peem
Published: April 2022

The scheme for accurate and reliable predictions of tunnel stability based on an artificial aeural network (ANN) is presented in this study. Plastic solutions of the stability of unlined elliptical tunnels in sands are first derived by using numerical upper-bound (UB) and lower-bound (LB) finite element limit analysis (FELA). These numerical solutions are later used as the training dataset for an ANN model. Note that there are four input dimensionless parameters, including the dimensionless overburden factor γD/c′, the cover–depth ratio C/D, the width–depth ratio B/D, and the soil friction angle ϕ. The impacts of these input dimensionless parameters on the stability factor σs/c′ of the stability of shallow elliptical tunnels in sands are comprehensively examined. Some failure mechanisms are carried out to demonstrate the effects of all input parameters. The solutions will reliably and accurately provide a safety assessment of shallow elliptical tunnels.
Study on Erosion Characteristics and Mechanisms of Recycled Concrete with Tailings in Salt Spray Environments
Authors: Xu Jin , Li Tao , Zhan Meng , Chen Xiuyun , Xu Fan , Wang Sheliang
Published: April 2022

To improve the utilization efficiency of iron tailings (IOT) and recycled coarse aggregate (RCA), the mechanical properties, erosion depth and other erosion characteristics of recycled aggregate concrete (RAC) with different IOT amounts were studied in salt spray erosion environments and the erosion mechanisms were analyzed by SEM technology. The results showed that at the same erosion age, IOT caused the compressive strength and splitting tensile strength of RAC to tend to first increase and then decrease, with the optimum mixing amount being approximately 40%. Under the same conditions, the erosion depth of RAC was much higher than that of ordinary concrete. The erosion depth first decreased and then increased with an increasing amount of IOT. When the IOT content was 30–40%, the salt spray erosion depth reached its minimum. The solidification coefficient K1 first decreased and then increased with the increase in iron tailings content. At its lowest point, the iron tailings content was approximately between 30% and 50%, which demonstrated that the higher the salt spray erosion age, the larger the solidification coefficient. Through SEM microscopic images, it could be seen that the appropriate amount of iron tailings caused the formation of salt spray erosion crystals and that the effect of physical expansion pressure caused a reduction in the porosity of RAC and a slight increase in its mechanical properties and salt spray erosion resistance. When the iron tailings content was large, the optimal mix ratio of the concrete also changed and then harmful pores and cracks were regenerated. Therefore, resistance to salt spray erosion was weakened. The research in this paper provides a theoretical basis for the engineering application of recycled concrete with tailings in salt spray environments.