bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Life History Dimensions in Reproductive Strategies Are Intuitive Across Cultures
Authors: Kruger Daniel J. , Fisher Maryanne L. , De Backer Charlotte , Kardum Igor , Tetaz Martin , Tifferet Sigal
Published: November 2023

Psychological research has been criticized for its extensive use of American university students to make broad claims about human psychology and behavior. Critics recommend a broader base of participants because there is substantial variability in experimental results across populations, and North American and Western European psychology pool participants may be outliers in comparison with the rest of the species. This challenge is especially pertinent for claims of species-universal evolved psychological architecture. One such claim has been made regarding recognition of human life history strategies. For example, previous research demonstrates that North American women and men can identify male and female characters with fast (high mating effort, low parental investment) and slow (low mating effort, high parental investment) life history strategies, make accurate predictions about their behavioral tendencies, and respond to them in ways that would facilitate participants’ own reproductive success. The current project validates the understanding of fundamental life history dimensions across a wide range of cultures, therefore supporting the idea that there is a universality in human’s ability to use, and perceive others’ use of, life history strategies. Results for each language sample replicated patterns from North American participants. Ratings for characters clustered into two dimensions, mating effort and parental investment. Items most central to the theoretical constructs had the highest factor loadings.
Father-child Interactional Synchrony in Brazilian Families With Maternal Depression
Authors: de Mendonça Júlia Scarano , Bussab Vera Sílvia Raad , Lucci Tânia Kiehl , Kärtner Joscha
Published: November 2023

In this study we were primarily concerned with paternal behavior with a focus on its proximal (immediate causation) and distal (function and evolution) levels of analysis, in the context of maternal depression. Several authors point out the flexibility of paternal caretaking in nature and argue that, in humans, it is facultative and, thus, more open to calculations of maximizing inclusive fitness than maternal behavior (Hrdy, 2014; Storey & Walsh 2011; Storey, Delahunty, McKay, Walsh, & Wilhelm, 2006). In addition, evolutionary approaches of depression offer functional analyses highlighting its adaptive function (Hagen, 1999; Price, 1967). From an evolutionary perspective, postpartum depression can have a signal function communicating mother’s need for extra support when she is unable to cope, especially from the partner (Hagen, 1999, 2002). Our main objective was to examine the associations between paternal behavior, maternal depression and family relationships. We hypothesized that when mothers are depressed, fathers assume a more active role within the family system, increasing investment to compensate for mother’s “partial functioning” due to depression, promoting their child’s well-being and, thus, potentially increasing their inclusive fitness. Forty-six father-child dyads were observed in a free-play situation and assessments of the degree of father-child interactional synchrony (interpersonal distance, visual and body orientation and dyadic involvement) were made. Greater father-child proximity and higher visual attunement, when mothers presented postpartum depression and later depression were found. These results were discussed in relation to the evolutionary hypothesis of depression, Trivers’ Parental Investment Theory and Family System Theory.
Sex Differences in Jealousy Are Not Explained by Attachment Style in Men and Women From Chile
Authors: Fernández Ana María , Muñoz-Reyes José Antonio , Dufey Michele , Pavez Paula , Baeza Carmen Gloria , Kinkead Patricia
Published: November 2023

Romantic jealousy is a sexually-differentiated emotion designed to secure reproductive liaisons. However, some suggest that sexual differences observed in the kind of infidelity that triggers jealousy cross-culturally could be only an artifact of attachment, shaping the masculine mind to develop a dismissing/avoidant attachment style, while the feminine attachment style is more likely to be anxious. This assumption was tested on a sample of 88 men and 170 women from Chile. The kind of infidelity that was more distressing was compared by sex and attachment style. As expected, results showed that men feel more jealousy distress by sexual infidelity scenario, while women by emotional infidelity scenario. However, Logistic Regressions did not support the proposition that attachment style may underlie sex differences in jealousy, because sex was the only significant predictors of the kind of jealousy that was more distressing. The discussion addresses the consistency of the evolved jealousy mechanism as plastic, but opened to specific contextual inputs other than attachment style.
The Cultured Chimpanzee: Nonsense or Breakthrough?
Authors: McGrew William C.
Published: November 2023

Controversy surrounds the claim that non-humans are culture-bearing creatures, yet the field of cultural primatology continues to progress. Using the chimpanzee as an example, this essay recounts the historical background to cultural primatology and its stage-wise development from natural history to ethnography to ethnology. First, it summarises the case for cultural primatology being nonsense, based on human uniqueness, dependency, transmission mechanisms, special pleading, language, and cumulative culture. Then, it counters with the case for cultural primatology being a breakthrough, citing multi-level comparative studies, universals, nuanced variation, and primate archaeology. Taking into account the strength of this diverse but convergent evidence, the breakthrough verdict is favoured.
The Trouble With Certainty in the Study of Human Evolution
Authors: Dávid-Barrett Tamás
Published: November 2023

A review of the book “The masters of the planet: the search for our human origins” by Ian Tattersall (2012).
“Disordered” behaviour. Alternatives to DSM-5 From an Ethological Perspective
Authors: Richer John
Published: November 2023

The shortcomings of DSM-5 and related psychiatric diagnostic systems are discussed, whilst maintaining sympathy for clinicians’ need for a shared category system. The ethological approach offers an alternative which promises to base clinical treatment on a more scientifically sound footing. Some examples of this approach are described, relating it to the behaviour of children diagnosed with ADHD or ASD; ethological concepts are used, such as behaviour observed when there are external or internal blocks to ongoing behaviour (frustration or motivational conflict), or behaviour seen along a dimension from simple displacement activities to playfulness. Concepts like pathology and disorder can be the object of study, but are not useful starting concepts to guide a scientific study; they are essentially practical and political concepts related to what a community agrees clinicians may treat. A scientific study acknowledges the need to study the range of human behaviour to provide a “map” to locate different behaviours, their causes, consequences and ontogeny, which then not only gives clinicians a better understanding and guidance to how to treat, but also can inform the societal debate about what they should treat.
Oral Contraception and Romantic Relationships—from the Lab to the Real World
Authors: Roberts S. Craig , Cobey Kelly D. , Klapilová Kateřina , Havlíček Jan
Published: November 2023

We review recent evidence that suggests that hormonal contraceptives may influence the dynamics of sexual relationships and the human pair-bond. Hormonal contraception likely has positive effects on cementing the pair-bond by decoupling sex from conception. However, changes in women’s evolved mate preferences associated with initiation or discontinuation of hormonal contraception may alter attraction to her partner, with potentially negative consequences for relationship satisfaction. We describe the evidence for such changes produced by laboratory studies, including prospective experimental designs, and how the consequences of such changes are being explored beyond the laboratory. In view of the growing prevalence of modern hormonal contraceptive methods across the globe, further study of such effects is urgently required.
Unique Aspects of Human Evolution
Authors: LaFreniere Peter
Published: November 2023

A review of the book “The Gap: The Science of What Separates Us from Other Animals” by Thomas Suddendorf (2013).
Defining Normal on the Playground: What Would Tinbergen Do?
Authors: Weisfeld Carol Cronin , Weisfeld Glenn E.
Published: November 2023

Using non-human animal models, ethologists have identified behaviors of children on the playground which have distinct behavioral ethograms and which seem to serve different functions. Play fighting may be seen between individuals of different size and power, especially if they reverse roles. Dominance-submission interactions often involve acts of power assertion among individuals who show reconciliation behaviors afterwards and who stay together in a stabilized hierarchical arrangement. Aggressive behaviors usually will not show such reversals, reconciliation, or stable pa%erns of affiliation. The literature on bullying, which was not founded on observation, has in all likelihood conflated these different behaviors; this confusion may help explain why bullying interventions often have li%le or no impact on changing children’s behavior.
Tinbergen’s Influence on Advances in Female Intrasexual Competition Research
Authors: Fisher Maryanne L.
Published: November 2023

Tinbergen (1963) proposed that there were four types of questions that could be used to collectively comprehend the biological underpinnings of behavior. These questions have been highly influential in several areas of investigation, and in this paper I review how they have shaped our understanding of women’s intrasexual competition for mates. While proximate (i.e., more descriptive and less adaption focussed) questions were historically popular, particularly among anthropologists who were among the first to document this behavior, there has been a recent shift towards understanding the ultimate level (i.e., evolutionary focussed) explanations for why these behaviors occur. This growing body of literature incorporates many sub-themes, such as voice perception, eating disorders, economic game theory, social psychology, pheromonal effects, and to a large extent, hormonal influences on behavior. I conclude with a short review of some of the topics that still require investigation in light of Tinbergen’s four questions.
Evolution—the Extended Synthesis: A Research Proposal Persuasive Enough for the Majority of Evolutionary Biologists?
Authors: Handschuh Stephan , Mitteroecker Philipp
Published: November 2023

A review of the book Evolution—the extended synthesis, edited by Massimo Pigliucci and Gerd B. Müller (2010).
Makna Life Goals dalam Film Rentang Kisah: Analisis Naratif Model Tzvetan Todorov
Authors: Putri Aji Devi , Adnani Kamila
Published: November 2023

The Rentang Kisah film is adapted from a best-selling novel which outlines the life journey of a Gita Savitri Devi. The purpose of this study is to describe the meaning of Life Goals in the film of Rentang Kisah through the analysis of Tzvetan Todorov's model. In this study, two problems were found, namely: first, how is the storyline of the film of Rentang Kisah examined through Tzevetan Todorov's analytical knife; and second, how the meaning of life goals in the film of Rentang Kisah is described in Tzvetan Todorov's narrative analysis. This researcher found several data findings that the storyline of the film of Rentang Kisah is depicted through 3 narrative lines in terms of the analysis of Tzvetan Todorov's model. There are 7 meanings of life goals found in the film texts studied, which include 4 meanings of life goals in the middle plot, and 3 meanings of life goals in the final plot. However, there is no life goals meaning in the beginning plot of the film.
DIALEKTIKA FILSAFAT DALAM SEJARAH ISLAM: PEMIKIRAN DAN PROBLEMATIKANYA
Authors: Muhammad Nazhif , Achmad Reza Hutama Al-Faruqi
Published: November 2023

Islamic philosophy has a long history of problems, both within and outside the Muslim body. Philosophy that originated in Greece has certainly given rise to judgment, condemnation, and even rejection from some Islamic circles. Al-Ghazālī (1058-1111 AD) with his book Tahāfut al-Falāsifah, which later made the stigma about philosophy worse and even led to his death, and which later appeared on the counter of an Ibn Rusyd with his book Tahafut At-Tahafut. This article highlights the thinking of Muslim philosophers and scholars in response to philosophy and mentions the reasons behind it, which will then be packaged in the form of the ups and downs of the development of Islamic philosophy. This article will also help decipher the origins of philosophy, its position in the tradition of thinking in Islam, and philosophy as a fusion between revelation and reason. This article's discussion uses a descriptive-analytical method that focuses on history. The results of this study can help recognize the role and position of philosophy in the intellectual history of Islam, which is then able to determine attitudes and views towards philosophy.
IMPLIKASI EPISTEMOLOGIS PEMIKIRAN FILSAFAT PAUL KARL FEYERABEND: KEBEBASAN AKADEMIK DALAM PENGEMBANGAN ILMU PENGETAHUAN ISLAM
Authors: Wahyudi M. Agus , Rijal Syamsul , Silahuddin  , Ikhwan M
Published: November 2023

Paul Karl Feyerabend has an idea called Epistemological Anarchism, which is a method used to criticize the establishment of knowledge with the aim of developing science itself. Academic freedom is one of the attitudes to develop knowledge while prioritizing objectivity. This research will discuss the implications of Feyerabend's thinking on developing knowledge and science in Islam. This research uses a library research approach with the method of collecting library data related to the research topic. The study results show that Feyerabend's concept of epistemological anarchism holds that there are no methodological rules in the development of knowledge and science. Feyerabend, finding a truth does not have to be through unnecessary falsification, but a truth can be found through new theories that have practical benefits. Epistemological anarchism has relevance to the epistemology of science development in Islam, namely as a way or steps to obtain educational knowledge based on Islamic fundamentals.
Pemberdayaan Ekonomi Masyarakat Berbasis Dana Sosial Keagamaan di Temanggung
Authors: Waluyo  , Piliyanti Indah
Published: November 2023

Dukuh Kandangan, in Tempuran Temanggung Village, consists of 130 families consisting of Christians, Muslims and Buddhists and live in harmony. The livelihoods of the majority are farmers and traditional ranchers. This community service is a form of support for strengthening religious moderation by empowering the community's economy based on socio-religious funds. Asset-based community development is used as a basis for the development of economic-based community empowerment. This approach focuses on developing community-based assets to support activities. This activity began with a focus group discussion (FGD) with academics to discuss the potential for community-based economic development in Temanggung. The results of this FGD were used to carry out interventions in the form of giving livestock which were managed by the community of three different religions in Dukuh Kandangan. These livestock become community assets to be jointly managed and used for the benefit of community capacity building.
WDR68 is essential for cellular proliferation induced by Adenovirus Type 5 E1A
Authors: wu zhao , xie lan , yuan ping , chu yi , peng hai
Published: November 2023

Despite previous data suggesting that the adenovirus 5 E1A protein
promotes quiescent cells entry into S-phase and stimulates cell
proliferation, the precise mechanisms are still debated. Here, we
demonstrate that WDR68, a highly conserved WD40-repeat protein,
significantly promotes cell proliferation and activates the
transcription of a large number of crucial genes in 293T cells alone, in
accordance with E1A protein. Subsequently, co-immunoprecipitation assays
showed that both E1A and WDR68 bind to the small pocket domain of RB,
and the interaction between E1A and RB does not depend on WDR68,
indicating that the above effect induced by WDR68 and E1A is not
involved in RB. Moreover, knock down of CtBP2, DYRK1B and FOXK1 in 293T
cells without WDR68 significantly stimulates transcription of a few
representative genes. These results suggested that binding of E1A to
WDR68 contributes it’s sequestering transcription corepressors CtBP2,
DYRK1B and FOXK1 and activates transcription of cell cycle-related
genes. Collectively, these findings show that WDR68 plays a central
factor in cell cycle progress-regulated by E1A and might be a potential
therapeutic target for adenovirus infection and adenovirus-related
tumors in future studies.
Effect of Foliar Application Nano NPK Fertilizers and Bio Stimulants on Growth, Yield, and Quality of Two Red Cabbage Cultivars (Brassica oleracea L. var. capitata rubra)
Authors: S. Saeed Dunya , M.S. Rasheed Sanaa
Published: November 2023

The experiment was done during growing seasons 2021-2022 in field condition at Protected cultivation Department/ in Zakho technical institute/Dohuk polytechnic university, to investigate the effect of Nano NPK fertilizers(0 and 2 g.l-1 ) and Bio stimulants (0, fulvic acid 0.5 g.l-1, amino acid 1g.l-1 and F+A g.l-1) on growth, yield, and quality of two red Cabbage Cultivars (Brassica oleracea L. var. capitata rubra) .The treatments will be arranged in split-split plot system. The fertilizers spray was done one month after transplanting and repeated three time interval 10 days between them. The result showed that the Nano NPK had no significant difference on the all parameters. fulvic acid (0.5 g.l-1 ) significantly increases head length (cm), head weight (kg) , and total yield (ton. ha-1). Number of leaves per plant increase with Amino acid (1 g.l-1.). While (F+A g.l-1) increased ascorbic acid (%), but bio stimulants no affected to anthocyanin (mg/100g) and carbohydrate (%) .The FIREBALL F1 cultivar significant increased No. of leaves per plant (leaf.plant-1), head weight (kg), total yield (ton. ha-1) and carbohydrate (%). While ZEINA F1 only increased ascorbic acid (%), but cultivars were not affected on head length (cm) and anthocyanin (mg/100g).The binary and triple interaction revealed that the combination between FIREBALL F1, fulvic acid (0.5 g.l-1 ) significantly increased almost all characteristics.
The role of mineralocorticoid receptors hyperactivation in the development of cardiorenal complications in patients with diabetes mellitus, perspective of the selective nonsteroidal mineralocorticoid receptors antagonist’s treatment: A review
Authors: Bobkova Irina N.
Published: November 2023

The renin-angiotensin-aldosterone system (RAAS) activation plays a key role in the chronic kidney disease (CKD) progression and in the cardiovascular complications (CVC) development in patients with diabetes mellitus (DM). RAAS blockers alone are not sufficient to prevent CVC and CVC progression. RAAS upregulation in CKD associated with DM triggers the mineralocorticoid receptors (MCR) hyperactivation which results in fibrosis and inflammation in the heart and kidneys. This review presents the current data about the variety of MCR hyperactivation manifestations, as well as about of multiplicity of MCR hyperactivation ways in DM. The efficacy and safety of finerenone, a new MCR nonsteroidal selective antagonist, are discussed.
A clinical and economic analysis of the use of dapagliflozin in patients with chronic heart failure in the entire spectrum of left ventricular ejection fraction in the Russian Federation
Authors: Nedogoda Sergey V. , Tereshchenko Sergey N. , Zhirov Igor V. , Salasyuk Alla S. , Barykina Irina N. , Lutova Viktoria O. , Popova Ekaterina A.
Published: November 2023

Aim. To estimate the cost-effectiveness of dapagliflozin across the range of ejection fraction in patients with heart failure (HF) in Russian Federation.
Materials and methods. Cost-effectiveness model was developed for estimate the use of dapagliflozin as part of standard therapy in patients with HF regardless of ejection fraction is unknown. The calculation of costs was carried out in a mathematical model adapted to the conditions of Russian healthcare system by using Russian costs inputs and patient population characteristics.
Results. In the model, dapagliflozin therapy yielded a mean of 0.209 additional life-years compared with standard of care in 10 years horizon. The incremental cost of 1 additional life-year was 665,715 RUB, which does not exceed the threshold of willingness to pay 2,235,202 RUB.
Conclusion. Thus, the intensification of chronic HF therapy with dapagliflozin is cost effective. The use of dapagliflozin in a cohort of 1000 target patients over 10 years will avoid 146 hospitalizations and 39 emergency visits due to HF, as well as prevent 32 deaths from cardiovascular diseases.
Hemostasis disorders in patients with systemic AL-amyloidosis
Authors: Rekhtina Irina G. , Khyshova Victoria A. , Zozulya Nadezhda I. , Dvirnyk Valentina N. , Mendeleyeva Larisa P.
Published: November 2023

Aim. To analyze the frequency and nature of hemorrhagic and thrombotic complications in patients with systemic AL-amyloidosis and compare with laboratory changes in the hemostasis system.
Materials and methods. The prospective study included 40 patients with newly diagnosed AL-amyloidosis. To detect amyloid, all patients underwent bone marrow trephine biopsy and duodenal biopsy, and 28 (70%) patients underwent biopsy of the affected organ. Before the start of therapy, all patients were determined the platelet count, activated partial thromboplastin time, thrombin time, fibrinogen concentration, time of XIIa-dependent fibrinolysis, antithrombin III, D-dimer, activity of blood coagulation factors VIII, X and vWF. The statistical part of the study was carried out using the IBM SPSS Statistics 2017 system software (SPSS, Chicago, IL, USA).
Results. In 20 (50%) patients, hemorrhages on the skin and mucous membranes were diagnosed as vascular purpura. Before the start of therapy, 7 (17.5%) patients had thrombosis, including leg vein thrombosis (5 patients), ischemic stroke (2 patients). There was a direct correlation between thrombotic complications and cutaneous hemorrhagic syndrome (p=0.007). In 15 (75%) cases, cutaneous hemorrhagic syndrome was accompanied by hypercoagulable shifts in the hemostasis system. Of the 20 patients with cutaneous hemorrhagic syndrome, 19 (95%) patients had kidney damage, including 15 patients with nephrotic syndrome. Hematoma type of bleeding, as well as heavy bleeding was not observed, including after a biopsy of the internal organs. According to the totality of hemostasis indicators, hypercoagulation syndrome was more often observed (in 23; 56% of patients). Hypocoagulation was diagnosed only in 2 (5%) patients with liver damage, 16 (39%) patients had normocoagulation.
Conclusion. Cutaneous hemorrhagic syndrome is the most common clinical manifestation of disorders in the hemostasis system in patients with AL-amyloidosis. The relationship of hemorrhages on the skin with nephrotic syndrome has been established, which may indicate a single pathogenetic mechanism. Cutaneous hemorrhagic syndrome is associated with hypercoagulable shifts in hemostasis and a high risk of thrombotic complications.
Relationship between the pain severity, use of non-steroidal anti-inflammatory drugs and blood pressure in elective large joint arthroplasty of the lower extremities
Authors: Okisheva Elena A. , Mironova Olga Iu. , Berdysheva Maria V. , Pyatigorets Evgenia S. , Krivova Natalya P. , Kurnosova Anna A. , Elizarov Mikhail  P. , Smetanin Sergey M. , Lychagin Alexey V. , Fomin Victor  V.
Published: November 2023

Aim. To evaluate the changes in blood pressure (BP), the severity of pain syndrome and non-steroidal anti-inflammatory drugs (NSAIDs) use patterns in patients hospitalized for elective arthroplasty of large joints of the lower extremities during the postoperative period.
Materials and methods. This study included 374 patients. In all patients, medical history, antihypertensive therapy and history of NSAIDs usage were collected, BP was measured, and the severity of pain was assessed via a 10-point scale before surgery, as well as 1 and 3 months after arthroplasty.
Results. The study included 132 (35.3%) males and 242 (64.7%) females. Among these, 289 (77.3%) patients had hypertension [grade 1 35 patients, grade 2 136 patients, grade 3 118 (25.0%) patients]; 280 (74.9%) patients were taking NSAIDs (121 daily, 135 23 times per week). The median pain severity before surgery was 8 points [7; 9], 1 month after surgery 2 points [1; 4], 3 months after surgery 1 point [0; 3]. At 1 month after arthroplasty, 23 (7.9%) patients reported a decrease in BP. In 17 (5.9%) patients, correction of previously prescribed antihypertensive therapy with a decrease in drug doses was required. At 1 month after arthroplasty, 256 patients discontinued NSAIDs. The analysis of the relationship between the severity of pain, NSAIDs use and the level of BP revealed a significant effect of pain syndrome (p0.0001) and the use of NSAIDs (p=0.014).
Conclusion. In the population of patients with elective arthroplasty of large joints of the lower extremities, a significant incidence of hypertension and a high prevalence of NSAIDs use are noted. During the postoperative period, a significant trend towards a decrease in the severity of pain was found, as well as the relationship of pain and NSAIDs with a decrease in BP.
Difficulties in differential diagnosis of the AL- and ATTR-cardiac amyloidosis. Case report
Authors: Orlov Filipp I. , Ansheles Alexey A. , Nasonova Svetlana N. , Saidova Marina A. , Zhirov Igor V. , Stepanova Elena A. , Suvorina Mariya Yu. , Shoshina Anastasia A. , Tereshchenko Sergey N. , Sergienko Vladimir  B.
Published: November 2023

The article presents a clinical case describing a complex differential diagnosis of cardiac amyloidosis types and verification of the diagnosis of AL-amyloidosis.
Sacubitril/valsartan in patients with mildly reduced or preserved ejection fraction and worsening heart failure: A review
Authors: Zhirov Igor V. , Safronova Natalia V. , Tereshchenko Sergey N.
Published: November 2023

Heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction are associated with significant morbidity and mortality, as well as growing economic burden. This review describes recent studies on the use of sacubitril/valsartan in heart failure patients with mildly reduced or preserved ejection fraction.
Sartans in the treatment of arterial hypertension: focus on telmisartan and azilsartan. A review
Authors: Zakiev Vadim D. , Kotovskaya Yulia V. , Tkacheva Olga N.
Published: November 2023

The activity of the renin-angiotensin-aldosterone system is one of the main pathogenetic mechanisms underlying cardiovascular diseases at all stages of the cardiovascular continuum. This article discusses the role of telmisartan and azilsartan as the most powerful sartans in modern cardiology. Azilsartan and especially telmisartan have a significant organoprotection and are superior to other antihypertensive drugs in terms of lowering blood pressure. However, the effect of azilsartan on hard endpoints has not been studied while the efficacy of telmisartan on hard endpoints has been evaluated in plenty clinical trials including 3 large randomized clinical trials with several thousand patients. The article also presents calculations showing the better cost-effectiveness of telmisartan compared to azilsartan.
Five-year dynamics adrenergic reactivity of erythrocytes after radio-frequency sympathic denervation of renal arteries in patients with resistant arterial hypertension
Authors: Rebrova Tatiana Yu. , Falkovskaya Alla Yu. , Afanasiev Sergei A. , Mordovin Viktor Fedorovich , Zyubanova Irina Vladimirovna , Muslimova Elvira Faritovna
Published: November 2023

Aim. To study the initial state of adrenergic reactivity and the five-year dynamics of the beta-adrenergic reactivity index of erythrocyte membranes and the manifestation of the antihypertensive effect of the procedure for radiofrequency destruction of sympathetic structures of the renal artery in patients with resistant arterial hypertension.
Subjects and methods. The analysis included 42 patients with resistant arterial hypertension (RH). The renal denervation (RD) procedure of the kidneys was performed by endovascular bilateral transcatheter radiofrequency ablation of the renal arteries. The study of 24-hour blood pressure monitoring (BPM) and the determination of -adrenoreactivity of erythrocytes (-ARM) by changes in the osmoresistance of erythrocyte membranes were performed initially, 1 week, 6 months, 1, 2, 3 and 5 years after RD. Patients retrospectively, at a follow-up period of 6 months after RD, were divided into responders (decrease in blood pressure by 10 or more mm Hg) and non-responders (decrease in blood pressure less than 10 mm Hg).
Results. 6 months after the RD, the number of responders was 28 people (66.7%), after 5 years - 31 people (73.8%). At the time of inclusion in the study, the median -ARM in the group of non-responders was not significantly higher than in the group of responders. After 6 months after the RD procedure, the -ARM indicator in the non-responder group was significantly lower than in the responder group (p = 0.043). With further follow-up in the group of responders, an increase in the median -ARM was noted, which reached significant differences relative to the baseline values in the group at follow-up periods of 1 year (p = 0.036) and 5 years (p = 0.004) after RD. The change in the -ARM indicator in the non-responder group was wavy in nature, the changes did not reach the significance criteria.
Conclusion. Renal denervation in 73.8% of cases is accompanied by a stable antihypertensive response for 5 years of observation and an increase in -ARM, which may indicate the implementation of compensatory mechanisms in conditions of increasing activity of the sympathoadrenal system in response to a decrease in blood pressure.
Indicators of cumulative disability due to malignant neoplasms of the brain for 2016–2021
Authors: Zapariy Natalia S. , Potapenko Olga I. , Vyalov Aleksandr V.
Published: November 2023

Background. One of the major issues of disability is improving the medical rehabilitation system for patients and disabled people due to malignant neoplasms of the brain. It is important to study the patterns of disability to develop effective medical and social rehabilitation methods for disabled people. Aim. To study the cumulative disability of the adult population due to malignant neoplasms of the brain in Moscow for 20162021 to develop measures for the prevention of morbidity and disability of this population, recommendations for improving comprehensive medical and social rehabilitation at all stages, and the provider of rehabilitation services. Materials and methods. It was a continuous study. The study included patients aged 18 years and older, examined and re-examined at the Bureau of Medical and Social Expertise due to malignant brain neoplasms in Moscow for 20162021. Results. Cumulative disability due to malignant neoplasms of the brain among the adult population of Moscow for 20162021 showed an increase in the total number of disabled people with a predominance of persons repeatedly recognized as disabled, the predominance of disabled people of working age with a tendency to rate increase, the predominance of malignant neoplasms of the brain (C71), frontal lobe (C71.1), and overlapping lesions of brain (C71.8); III disability category and males prevailed.
Importance of the reformed oncology education for today's specialists
Authors: Reshetov Igor V. , Fatyanova Anastasia S.
Published: November 2023

The article reflects practical aspects of the introduction of a new professional standard of oncologist. These are segreagation of competences according to the new labor functions, admission to professional retraining in oncology of doctors of new specialties, preparation of a new educational standard, as well as new requirements for work experience in the main specialty for retraining.
Observational studies as a tool for introducing innovative oncology approaches into clinical practice: A review
Authors: Khatkov Igor E. , Andreyashkina Irina I. , Anichkina Kristina A. , Pasternak Alina V. , Prokofieva Elizaveta S. , Zaitsev Roman D. , Trotsenko Ivan D.
Published: November 2023

Randomized clinical trials (RCTs) are the gold standard of evidence-based medicine. However, it is no less evident that real practice presents many new and important questions that are difficult to answer in the RCT. To what extent does the real patient meet the criteria for inclusion in the study? What are the efficacy and safety of the drug in comorbid and elderly patients? How deviations from the treatment regimen affect safety, etc. The introduction of innovative oncology approaches is disproportionately faster than in other fields. That is why a balanced analysis of the effects of innovation in real-world practice is relevant. Regulatory authorities are aware of this and demonstrate a willingness to consider and actively support real-world evidence research as part of drug applications, which is a powerful incentive for developing this area. The purpose of the article is to analyze the regulatory approaches in the United States and Europe to real-world studies when considering drug applications and to discuss the experience of organizing an observational study of the effectiveness of individual drugs for the treatment of oncological diseases in Moscow as a unique example of interaction between regulatory authorities and the expert community of oncologists.
DEVELOPMENT OF ARCS-BASED LEARNING TOOLS CONTAINING HOTS QUESTIONS TO IMPROVE THE CRITICAL THINKING ABILITY OF CLASS VIII SMP/MTS STUDENTS
Authors: Putri Fauziah Putri , Yerizon Yerizon , Arnawa I Made , Syafriandi Syafriandi
Published: November 2023

The literature study and preliminary analysis conducted showed that students' critical thinking skills were still low. This study aims to determine the characteristics of Attention, Relevance, Confidence, Satisfaction (ARCS)-based learning tools that contain valid, practical, and effective HOTS questions to improve the critical thinking skills of class VIII students of SMP N 6 Padang Panjang. This research is a development research using the Plomp model. The learning tools developed are in the form of Learning Implementation Plans (RPP) and Student Activity Sheets (LKPD). The research subjects were students of class VIII SMP N 6 Padang Panjang. Data was collected through documentation, observation, interviews, questionnaires, and tests of critical thinking skills. RPP Validity Score: 3.28 and LKPD: 3.21 with a valid category. Practicality of RPP: 92.08% and LKPD: 87.35% with very practical category. The effectiveness of learning tools based on testing the average critical thinking skills of the experimental class was 81.93, control class was 76.63. Based on statistical tests, a significance value of 0.048 <0.05 was obtained, and based on the list of t distribution tables with (𝑑𝑓)=60 and a=0.05, 1.671. Because t_count= 2.108>1.671=t_(table) then H0 is rejected and accepts H1. Based on the test results, it can be concluded that the ARCS-based learning tools contain HOTS questions that meet valid, practical, and effective criteria to improve students' mathematical thinking skills.
Development of Problem-Based Mathematics Learning Media in the Independent Curriculum
Authors: Nurvicky Febry Fajar , Effendi Moh Mahfud , Susanti Reni Dwi
Published: November 2023

This study aims to develop mathematics learning media with the Microsoft Office 365 Powerpoint program, the Problem-Based Learning model assisted by the TikTok application in an independent curriculum. In developing this learning media, researchers used the ADDIE development type (Analysis, Design, Development, Implementation, and Evaluation) with 30 students as respondents in mathematics at MTS Muhammadiyah 1 Malang. Data collection techniques were in the form of questionnaires which included observation and interview questionnaires, media and material validation questionnaires, as well as pre-test and post-test questionnaires. The feasibility test Assessment by material experts includes learning objectives, learning methods, learning resources, learning activities, and learning materials, 77% of which are categorized as very feasible. Then the media was tested in the class before and after being given the media test treatment. The results were 0.028 with the treatment category before and after using the TikTok application-based learning media. In this case, it means that the mathematics learning media combined with the TikTok application is very feasible to use.
Do Smallholder Farmers Need Paddy Microtakaful Scheme?
Authors: Salleh Fauzilah , Bakar Nor Mazlina Abu , Ismail Nur Salina , Rashid Norfadzilah , Deraman Wan Jemizan Wan
Published: November 2023

Smallholder farmers play a crucial role in the agricultural sector of developing nations, but they are exposed to a number of risks that could result in sizable financial losses. As an alternative risk-sharing mechanism that can assist smallholder farmers in effectively managing their risks, microtakaful has been introduced. The article intends to propose the Paddy Microtakaful Scheme (PMTS) exclusively for smallholding farmers in Malaysia. This protection is significant for smallholder farmers to provide sustainable economic growth and food security. A few key areas must be observed to understand the necessity of having the scheme. An overview of Malaysia’s agriculture sector is presented focusing on land use, employment, and production of food crops among the smallholder farmers. Risks and perils in agriculture, including natural disasters, pests, and crop diseases, are also outlined. The role of PMTS is also discussed, highlighting its many benefits to smallholder farmers. A survey was carried out among 275 smallholder farmers to gain information on their demographic profiles, farming activities as well as their willingness to contribute to the PMTS. The information is vital in developing a suitable and well-accepted PMTS, specifically among smallholder farmers in Malaysia. The PMTS framework presented in this report is based on a hypothetical product that contains four main attributes: 1) types of crops to be insured, 2) type of coverage, 3) contribution or the price, and 4) sum assured/benefit. The scheme includes coverage for natural disasters, pests, and crop diseases with the ultimate objective to reduce the vulnerability of the global food system. Further research will consist of the execution of a pilot program formulated to evaluate the effectiveness of PMTS. With the government’s three-way coordination and active roles, the smallholder farmers and Takaful company will become the essential constituents in realizing the PMTS.
Validity and Practicality of the E-Book Science Model RADEC (Read-Answer-Discuss-Explain-Create) to Improve the 4C Skills of Students
Authors: Pramita Rissa , Yulkifli Yulkifli
Published: November 2023

Quality human resources are the main goal of a nation's ability to compete. The demands of the 21st century also require quality human resources. Therefore, learning resources are needed that support students' 4C skills. The purpose of this research is to develop learning resources in the form of science e-books that have been tested for validity and practicality. The type of research used is research and development, using the ADDIE development model. In the ADDIE development model, there are five stages, including analysis, design, development, implementation, and evaluation. The validity of the Science E-Book uses the Aiken's V scale, and the practicality of the Science E-Book uses the Likert scale. Based on the results of the data analysis conducted, the validity and practicality results were obtained as follows. The results of e-book validity tests by experts were obtained at 0.88. The results of the teacher's practicality were obtained at 89.25%, and the results of the students' practicality were obtained at 88%. So it can be concluded that the RADEC model-based science e-book (Read-Answer-Discuss-Explain-Create) is valid and practical to use in science learning and to improve the 4C skills of junior high school students.
Diagnostic and therapeutic profile of patients treated for breast cancer in a radiotherapy unit: case of Dalal Jamm Hospital, Senegal
Authors: Mouhamadou Bachir Ba  , Rachidou Hamadou  , Papa Alioune Diagne  , Fatimatou Néné Sarr  , Pape Massamba Diéné  , Kanta Ka  , Lamine Gueye  , Doudou Diouf  , Papa Macoumba Gaye
Published: November 2023

Objective: Describe the epidemiological, diagnostic and therapeutic profile of breast cancer in Senegal. Patients and Methods: One hundred and sixty patients with histological confirmation of breast cancer, treated consecutively between June 2018 and December 2020, were retrospectively included. Predefined clinical data were extracted from medical records containing patient demographic information, medical history, diagnostic features, and different treatment types. Data were collected, entered and analyzed using SPSS version 23.0 software. Results: The median age of the participants was 48 years with extremes of 27 and 81 years. The average consultation time was 4 (± 2.6) months. Breast cancer was mainly discovered to clinical signs (91.3%). Screening mammography revealed only 5% of cases. The vast majority of patients had a tumor larger than 3 cm (78.2%). Molecular characterization by immunohistochemistry was studied in 87 patients (54.3%) with a predominance of the triple negative profile (36.8%). Neoadjuvant chemotherapy was performed in 111 patients (74%). One hundred and thirty-five patients (92.5%) had undergone a mastectomy with modified Patey type dissection and only 11 patients (7.5%) had conservative treatment. The histological complete response rate after neoadjuvant chemotherapy was 17.1%. The median time between surgery and radiotherapy was 6 months. All patients in the series received radiotherapy. It was adjuvant in 142 patients and exclusive for palliative purposes in 18 patients. It was moderately hypofractionated in 105 patients (65.6%); classic in 52 patients (32.5%). Acute toxicities of radiotherapy were mainly represented by grade 1 radiodermatitis (22.5%). Conclusion: The descriptive analysis of these results shows the young age of the patients, the late diagnosis of breast cancer in our context and a treatment which is essentially based on neo-adjuvant chemotherapy and radical mastectomy.
Nalar Kemanusiaan dalam Da’wah Multikultural:
Authors: Yulianto Hendra Bagus
Published: November 2023

Islam taught by Allah as well as being exemplified by the Prophet is a universal teaching which is manifested through the tagline Islam rahmatan lil alamin, being able to give grace to anyone, including the society where da'wah entity is carried out. But in reality there is a gap where das sein da'wah which is practiced not only hasn't been able to answer social problems in the society, but also it has also contributed to creating problems, that is violence in the name of religion. The dynamics of this issue are very vulnerable, especially in the context of a multicultural society whose existence is built on the foundation of diversity. This research wants to offer an alternative approach in humanist da'wah, especially in formulating da'wah messages by making humanity values as as humanist perspective in a multicultural society. Humanity values are expected to be able to become a da'wah approach, especially in the context of a multicultural society, including: the value of truth, the value of virtue (right conduct), the value of non-violence , the value of love or love, and the value of peace
PERAN MAJELIS PENDIDIKAN DASAR DAN MENENGAH MUHAMMADIYAH DALAM PENGEMBANGAN LEMBAGA PENDIDIKAN DI KABUPATEN KEPAHIANG
Authors: Yurika Tince Ajeng , Sugianti Iis , Fathurrochman Irwan , Asha Lukman
Published: November 2023

This study aims to describe the role of the Muhammadiyah Elementary and Secondary Education Council in the Development of Educational Institutions in Kepahiang Regency. This study aims to determine to what extent the role of the Elementary and Secondary Education Council has carried out its duties and functions which are one of the components of the leadership assistant in the Muhammadiyah organization in the field of education. This research method uses a descriptive qualitative approach. with the technique of collecting data from observations, interviews, to the chairman of the Kepahiang District Educational Council and supported by some related literature. The research data is reduced and presented, then analyzed for several conclusions. The results showed that; Providing assistance for learning facilities seeking facilities and infrastructure as well as financing providing facilities for learning activities through sports, scouting and religious activities to support the quality of educational institutions to develop better and superior, improve the quality of human resources for educators through routine training and guidance from relevant agencies and carry out learning evaluations at each educational institution how to view monthly performance reports, this is in accordance with the duties of the Dikdasmen assembly, namely as follows.
KOMUNIKASI LINGKUNGAN: UPAYA MEWUJUDKAN ARBORETUM GAMBUT SEBAGAI EKOWISATA DI KABUPATEN BENGKALIS
Authors: Primananda Anissa Febriani , Moekahar Fatmawati
Published: November 2023

The Peat Arboretum is one of the PT. Pertamina RU II, Sungai Pakning which is managed by the Kampung Jawa community group. This research was motivated by the discovery of land that was saved from peatland fires around Kampung Jawa in the 2013-2015. Basically, the people of Kampung Jawa are people with low education and lack of public awareness of environmental sustainability as an edutourism area. Therefore, this research aims at how PT. Pertamina RU II Sungai Pakning through its CSR activities communicated in building community participation to realize the Marsawa Peat Arboretum as ecotourism in Bengkalis Regency. In this study using qualitative research methods with a descriptive approach. research subjects were determined based on purposive sampling technique. Data collection techniques were carried out through in-depth interviews, observation, and documentation. The results of this study indicate that the environmental communication carried out by PT Pertamina in the CSR program in realizing the Peat Arboretum as ecotourism is carried out through several stages, namely assessment, planning, production and action and reflection. Of the four, community participation in realizing the Peat Arboretum as ecotourism in Bengkalis Regency has been effective, this can be seen from the voluntary community involvement in programs that lead to social change. The four stages are educational, solution and comprehensive efforts in realizing the Peat Arboretrum as Ecotourism in Bengkalis Regency.