bluuebunny/crossref_metadata_2025 huggingface dataset:
DEVELOPMENT BANKING IN INDIA
Authors: Dr. Anjali Gupta  , Dr. Purushottam Kumar Arya
Published: August 2020

Development banking in India is almost as old as India’s independence. The emergence of development banking in India
is a post-independence phenomenon. Development bank is essentially a multi-purpose financial institution with a broad
development outlook. It is a financial institution which provides all types of financial assistance (medium as well as longterm) to business units, by way of providing loans, underwriting, investment and guarantee operations and promotional
activities – economic development in general and industrial development, in particular. Through this discussion we try to
highlight the phases through which Development Banking in India underwent, purpose for which they were established
and how they are different from commercial banks in India. We also try to stress on the extent to which presence of
Development Banks is relevant and important in the current scenario.
KEY WORDS: Development Banks ,Capital Market, Commercial Banks, Financial Institutions, Foreign Exchange
3. The Anti-Ecological University: Competitive Higher Education as Ecological Catastrophe
Authors: Morini Luca
Published: August 2020

Abstract The article aims at critiquing the current competitive framing which is shaping higher education policies and discourse at an international level. The argument initially takes an historical and genealogical approach to trace the roots of this
framing to ideological misinterpretations of evolutionary theory and ecology, and to the influence of eugenics in the framing of educational policy. The article then uses a systems theory lens to articulate the negative impact of competitive dynamics in global education on an ecosystemic level,
focusing on a “deecologization” of the two dimensions of time and space in the lives of university students and staff. Finally, the article concludes suggesting the necessity of an imaginative reecologization of thought as a precondition for any sustainable change in Higher Education
philosophy and policy.
Prognostic Value of EGFR Expression for Patients With Stage III Colorectal Cancer Receiving Fluoropyrimidine Metronomic Maintenance Therapy After Radical Resection and Adjuvant Oxaliplatin-Based Chemotherapy
Authors: Huang Ching-Wen , Ma Cheng-Jen , Su Wei-Chih , Chen_ Yi-Ting , Tsai Hsiang-Lin , Yeh Yung-Sung , Chang Tsung-Kun , Hsu Wen-Hung , Yu Fang-Jung , Wang Jaw-Yuan
Published: August 2020

This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression. We enrolled 197 patients with stage III CRC who had undergone radical resection and FOLFOX regimen adjuvant chemotherapy. The clinicopathological features and effects of metronomic maintenance therapy with oral capecitabine (daily dose of 850 mg/m2, twice daily, on days 114 every 3 weeks for 6 months) on survival according to treatment group and EGFR expression were analyzed. By conducting an in vitro cell line study and in vivo study through knockout of theEGFRgene, we analyzed the capacities of cell proliferation and migration. Relapse and survival were significantly more common in the FOLFOX group. Metronomic maintenance therapy was a significantly independent associated factor of relapse and survival as well as a prognostic factor of disease-free survival and overall survival. Significant intergroup differences in survival were only observed in patients with positive EGFR expression. Thus, our findings suggest EGFR expression is a prognostic factor in patients with stage III CRC receiving metronomic maintenance therapy. Analysis of EGFR expression in these patients helps identify potential candidates who may receive the optimal survival benefit from metronomic maintenance therapy.
Pedagogical Analysis Of Culturo-Educational Institutions’ Actions In Youth Education (On The Example Of Museum Activities)
Authors: Ahmadjonovna Egamberdieva Turgunoy , Bakhromovich Siddikov Ilyosjon
Published: August 2020

The article examines the problems associated with the education of young people of today’s, the processes of transformation in the national education system as a result of the era of globalization. The modern pedagogical functions of cultural and educational institutions, in particular museums, in raising the moral culture of young people have been studied as an important field.
Bolster Barrier (BOLER) as a Guardrail Impact Device to Enhance Energy Absorbtion
Authors: Sahekhaini Asnizah , Salleh Bibie Sara
Published: August 2020

Guardrails are the most important road furniture which prevent vehicles from going off the road or into the opposite lane. It also protects objects at the roadside and prevent vehicles from entering into dangerous areas such a ravine or river. Performance of guardrails is not only influenced by their own design, but also the design of the vehicle. The design of guardrails is mostly aimed to reduce serious effects towards vehicles and users in an event of an accident. Bolster Barrier (BOLER) is an impact device that enhances the existing W-shape guardrails that are intended to reduce the accident impact between road users and the guardrails themselves. The application of BOLER is focused at critical areas. The purpose of this device is to reduce the numbers of serious injuries and fatalities in an accident. BOLER involved an impact test known as dolly test at MIROS Lab, Provisional CRASE Crash Centre (PC3) of Ayer Molek, Melaka. The test measured the dolly’s velocity, W-beam guardrail bar’s deformation and the overall force overtime trace. The results for standard the W-beam guardrail with new impact device showed a lower peak force (47.6kN versus 51.5kN) and a delay in reaching peak force by 11.4 milliseconds as compared to guardrails without the new guardrail device. This delay of 11.4 milliseconds is crucial allowing airbags to inflate before full impact.
Chemical Composition and Antibacterial Activities of the Essential Oils from the Leaves of Premna angolensis and Premna quadrifolia, Two Lamiaceae from Côte d’Ivoire
Authors: Séraphin KOUASSI Kouamé , Antoine KOUAME Bosson , Akhanovna MAMYRBÉKOVA-BÉKRO Janat , YvesAlain BEKRO , Yvette FOFIE N’guessan Bra
Published: August 2020

This study was conducted with the objective of contributing to the valorization of aromatic and medicinal plants of Côte d’Ivoire. The essential oil (EO) of the leaves of two species of Premna, P. angolensis and P. quadrifolia obtained through steam distillation process, were analized through gas chromatography coupled with mass spectroscopy (GC-MS) and their antimicrobial activities was evaluated by agar diffusion method. The yields of EO extracted from the leaves of P. angolensis and P. quadrifolia are respectively 0.10 ± 0.02% and 0.40 ± 0.02%. 99.43% of the total chemical composition of the EO of P. angolensis leaves, are composed mainly of hydrocarbon sesquiterpenes (71.90%) followed by oxygenates (14.16%) and monoterpenes (13.22%). The main compounds found are β-caryophyllene (33.07%) and Humulene (10.78%). The EO of P. quadrifofia leaves, 99.59% of the composition was identified. It contains hydrocarbon sesquiterpenes (89.15%), followed by oxygenates compounds (8.61%) and monoterpenes (1.83%). The major compounds are αbulnesene (23.33%), germacrene D (18.83%) and caryophyllene (18.06%). The antimicrobial tests have shown that EO of P. quadrifolia leaves has no activites on studied strains and P. angolensis oil has a mild activity on Staphylococcus epidermidis and Klebsielle pneumoneae and a weak sensibility on Staphylococcus aureus CIP 4.83 and Candida albicans ATCC 10231. This study highlights chemical composition of the EO from P. angolensis and P. quadrifolia leaves. It shows more similarities of the chemical compositions of these two species of Premna and the interesting antimicrobial activity potential of P. angolensis EO
Dégoût et normes d'hygiène dans un métier de soin des apparences
Authors: Desprat Diane , Noûs Camille
Published: August 2020

Cet article repose sur une enquête réalisée entre 2013 et 2017 et s'appuie sur 76 entretiens et 26 semaines d'observations multi-situées dans des centres de formation publics et privés et des salons mixtes de standings différents. Il s'agit d'analyser comment les coiffeurs·euses débutant·e·s incorporent un ensemble de normes professionnelles ayant trait à l'hygiène corporelle tant dans leur apprentissage qu'en situation de travail. L'incorporation des règles d'hygiène formelles et informelles au long de la socialisation professionnelle transforme le rapport au corps et à l'apparence des apprenti·e·s. Faisant l'expérience par corps du dégoût pour le « sale », cette socialisation professionnelle implique un travail de soi et un contrôle des pairs sur la présentation de soi qui est constitutif du métier, de l'identité professionnelle et du sens donné à la relation de service face à une clientèle hétérogène. Les futur·e·s coiffeurs·euses deviennent davantage sensibles à ces aspects et se surprennent alors à éprouver du dégoût vis-à-vis de certain·es client·es jugé·es « malpropres ».
Parler en expert·e·s
Authors: Boni-Le Goff Isabel , Noûs Camille
Published: August 2020

Le cas des consultant·e·s en management donne à voir ce que la légitimité d'une expertise doit aux pratiques complexes associant des performances vocales et corporelles à des éléments discursifs. Envisagées dans leurs différentes dimensions, ces pratiques langagières concrétisent et mettent en visibilité l'expertise et permettent le passing expert. Le travail qui permet d'acquérir ces façons de parler en expert·e est activement encouragé et institutionnalisé par les entreprises de conseil. Mais, si chaque consultant·e est invité·e à se conformer à des normes professionnelles spécifiques pour « parler en expert·e », cette dimension du métier expose les consultantes à des difficultés spécifiques et à des expériences régulières de disqualification genrées.
La valeur professionnelle de l'identité
Authors: Bereni Laure , Noûs Camille
Published: August 2020

En s'appuyant sur une enquête comparative auprès de managers de la diversité en entreprise dans les régions de New York et de Paris, cet article explore les logiques de réalisme identitaire au sein d'emplois qualifiés. Inspirée du concept de «  racial realism  » (Skrentny, 2013), cette notion désigne le fait de considérer l'identité sexuée et racialisée comme une compétence professionnelle. Aux États-Unis comme en France, les corps sexués et racialisés des managers de la diversité signalent la saillance de la race et du genre dans la définition gestionnaire de la diversité, au-delà de la vulgate célébrant une infinité de différences. Mais alors qu'aux États-Unis l'identité « minoritaire » (de race, mais aussi de sexe) est perçue comme une qualité professionnelle pour exercer cette fonction, en France au contraire c'est l'identité « majoritaire » (là encore de race et de sexe) qui apparaît comme une ressource. Ce contraste confirme l'importance de placer les corps des travailleurs et des travailleuses au c ur de l'analyse des dispositifs gestionnaires, révélant ici l'influence des problématisations nationales de l'égalité et de la différence sur les appropriations pratiques d'un discours managérial transnational.
Des rapports de pouvoir à l'œuvre
Authors: Harchi Kaoutar
Published: August 2020

Le présent article rend compte des rapports de pouvoir à l'œuvre lors du processus de consécration littéraire des auteurs algériens de langue française Kateb Yacine (1929-1989) et Kamel Daoud (1970-), en France. À partir d'un corpus d'étude constitué d'entretiens semi-directifs, de discours littéraires et méta-littéraires et d'une documentation de nature variée, nous montrons que les rapports de pouvoir, signes d'une consécration « en demi-teinte », procèdent de l'organisation inégalitaire du champ des lettres françaises au sein duquel l'origine nationale agit comme opérateur hiérarchique. Cette démarche, sensible à la nationalisation de la normativité littéraire, permet dès lors d'éclairer les modalités de formation de la croyance en la valeur littéraire en situation postcoloniale ainsi que les usages stratégiques des œuvres en dehors de leur champ de production originel.
DAYS ALIVE OUTSIDE HOSPITAL AND RE-ADMISSIONS IN PATIENTS UNDERGOING ALLOGENEIC TRANSPLANTS FROM IDENTICAL SIBLINGS, UNRELATED DONORS OR HAPLOIDENTICAL DONORS “.
Authors: Sorà Federica , Chiusolo Patrizia , Laurenti Luca , Innocenti Idanna , Autore Francesco , Giammarco Sabrina , Metafuni Elisabetta , Alma Eleonora , Di giovanni Alessia , Sica Simona , Bacigalupo Andrea
Published: August 2020

We have studied the number of days alive outside Hospital (DAOH) and the number of re-admissions within the first 100 days after transplant in 185 patients who received an allogeneic hemopoietic stem cell transplant (HSCT). The donors were matched siblings (SIB; n=61), or alternative donors (ALT; n=124). The median number of DAOH for SIB transplants (78 days) was significantly greater than DAOH for ALT donor grafts (73 days) (p=0.0003) . Other positive predictors of DAOH were the use of reduced intensity regimens (p=0.01), grade 0-I graft versus host disease (GvHD) (p=0.0006) and a comorbidity index equal or less than two (p=0.04). Fifty one patients required re-admission (22%), which was predicted by grade II-IV GvHD (p=0.009), higher comorbidity index (p=0.06) and ALT donors as compared to SIBS (p=0.08). The CI of re-admission was 18% for SIB and 30% for ALT donor grafts. The non relapse mortality (NRM) for patients re-admitted was 25%, compared to 5% for patients not readmitted (p=0.0001). In a multivariate analysis re-admission was the strongest predictor of non relapse mortality (NRM) (p=0.0006) and survival (p<0.0001).

In conclusions: ALT donor transplants have lower numbers of DAOH, as compared to SIB grafts, which implies longer stay in hospital and greater cost. Re-admission to Hospital within 100 days, is predicted by GvHD, comorbidity index, donor type, and has a very strong impact on non relapse mortality and survival.
Cytomegalovirus genotype distribution among postnatally infected infants: association of glycoprotein B, glycoprotein N and glycoprotein H types with CMV-associated thrombocytopenia
Authors: Hu Hongbo , Cheng Ying , Peng Qiaoying , Chen Kun
Published: August 2020

The aim of the present study was to identify the virulence of glycoprotein B (gB), glycoprotein N (gN), and glycoprotein H (gH) genotypes of cytomegalovirus(CMV) and assess possible relationships between genotypes and CMV-associated thrombocytopenia. CMV gB, gN, and gH strains were determined by nested PCR and restriction length polymorphism from 30 CMV-associated thrombocytopenia infants infected postnatally and 40 non-thrombocytopenic infants. The gN2 (p = 0.043) and gH2 (p = 0.038) genotypes were associated with an elevated risk of developing thrombocytopenia. gB1 genotype was detected in 80.0% (16/20) of infants with moderately to severely symptomatic CMV disease and was associated with severe manifestations in CMV-associated thrombocytopenia infants (p = 0.022). Conversely, the gN1 genotype was detected in 5.0% (1/20) of infants with moderately to severely symptomatic CMV disease and represent less pathogenic CMV strains (p = 0.044). There may be potential associations between the gN2 and gH2 genotypes of CMV and infantile thrombocytopenia, and that the detection of the gB1and gN1 genotypes may help define the severity of CMV disease in infants.
Factors VIII and von Willebrand levels in women undergoing Assisted Reproduction: are their levels associated with clinical pregnancy outcome?
Authors: Attanasio Monica , Cirillo Michela , Coccia Maria Elisabetta , Castaman Giancarlo , Fatini Cinzia
Published: August 2020

A growing number of infertile women are considering pregnancy through assisted reproductive technologies; hormonal fertility treatment is associated with a procoagulant milieu. In oocyte donation Assisted Reproductive Technologies there are patients who experience repeated implantation failures, as well as biochemical pregnancy, in particular in women at advanced age (>40 yrs). No information is available concerning coagulation changes in women undergoing oocyte donation.

In this study, we decided to identify changes in haemostasis in women undergoing infertility treatment and their relationship with clinical pregnancy outcome.

 Our findings evidence an early increase of FVIII and VWF coagulation proteins, suggesting their potential role as early “predictors” of a successful clinical pregnancy in oocyte donation women. This may be intriguing for exploring potential mechanisms responsible for the establishment of a successful pregnancy after oocyte donation.
CYTOMEGALOVIRUS-INDUCED GASTROINTESTINAL BLEEDING AND PANCREATITIS COMPLICATING SEVERE COVID-19 PNEUMONIA: A PARADIGMATIC CASE.
Authors: Marchi Giacomo , Vianello Alice , Crisafulli Ernesto , Maroccia Alessio , Crinò Stefano Francesco , Pecori Sara , Zamboni Giulia A , Mazzaferri Fulvia , Tacconelli Evelina , Girelli Domenico
Published: August 2020

Key points:

COVID-19 is a novel pandemic disease whose pathophysiology and clinical description are still not completely defined.

Besides respiratory symptoms, gastrointestinal (GI) symptoms (especially including anorexia, diarrhea, and abdominal pain) represent the commonest clinical manifestations.

Emerging data point out that severe SARS-CoV-2 infection causes an immune dysregulation, which in turn may favor other infections.

Here we describe a patient with severe COVID-19 pneumonia who developed in the resolving phase abdominal pain associated to cytomegalovirus (CMV)-induced duodenitis with bleeding, and pancreatitis.

A high level of suspicion toward multiple infections, including CMV, should be maintained in COVID-19 patients with heterogeneous clinical manifestations.
SARS-CoV-2 Trasmission and Outcome in Neuro-rehabilitation patients hospitalized at Neuroscience Hospital in Italy
Authors: Di Gennaro Francesco
Published: August 2020

ABSTRACT

Introduction:  Patients admitted to intensive neurorehabilitation facilities following neurological damage who developed SARS-CoV-2 infection during hospitalization have not yet been reported. Such patients are elderly, with severe disabling neurological syndromes, more likely have significant underlying comorbidities and develop fatal complications during the disease. We reported clinical features, underlying comorbidities, laboratory and radiological findings, treatment and outcome of severely disabled neurological patients with SARS-CoV-2 infection.

Methods:  We retrospectively analyzed a group of 14 patients affected by severe neurological damage previously admitted to the Neurorehabilitation Unit of Neuromed Research Institute in Pozzilli, Italy, who developed confirmed COVID-19 during a SARS-CoV-2 outbreak occurred on March, 2020.

Results:  One out of 14 patients (7%) died after developing a severe acute respiratory distress. The remaining patients did not present any symptom or laboratory or radiological signs of the disease; neither new neurological deficit nor worsening of the pre-existing clinical manifestations were observed. Thirtheen patients had underlying comorbitidies (93%), the most frequent being hypertension (11 patients, 78.5%) and diabetes mellitus type II (7 patients, 50%). Long before infection, all patients were already under anticoagulant therapy with enoxaparin.

Conclusions:  In 13 out of 14 patients, the infection was asymptomatic; this is particularly intriguing considering their severe neurological clinical profile. According to the pivotal role played by inflammation and activation of blood coagulation in the pathogenesis of COVID-19, the anti-inflammatory and anticoagulant properties of enoxaparin, administered much earlier and during infection, could have favored an extremely benign disease course in these patients at high risk of poor outcome.

Keywords: SARS CoV 2, neurological patients, neurological damage, Infection, Coronavirus
How I treat acute and persistent sickle cell pain
Authors: Ballas Samir
Published: August 2020

Sickle pain is the hallmark of sickle cell disease (SCD). It could be acute, persistent/relapsing, chronic or neuropathic. Although there is a general consensus that pain is a major manifestation of SCD there is a controversy as to the types of pain and their interrelationship between acute, chronic, relapsing, persistent, etc. This report first reviews the general approach to the management of acute vaso-occlusive crisis (VOC) pain including education, counseling, pharmacotherapy, non-pharmacotherapy, and fluid therapy. This is followed by the presentation of five patients that represent typical issues that are commonly encountered in the management of patients with SCD. These issues are: individualized treatment of pain, bilaterality of pain, use of illicit drugs, tolerance to opioids, opioid induced hyperalgesia and withdrawal syndrome. The clinical aspects and management of each of these issues are described. Moreover, such complications as tolerance and withdrawal may persist after discharge and may be mistaken as chronic pain rather than resolving, persistent or relapsing pain.
Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts.
Authors: Dragani Matteo , Petiti Jessica , Rege-Cambrin Giovanna , Gottardi Enrico , Daraio Filomena , Caocci Giovanni , Aguzzi Chiara , Crisà Elena , Andreani Giacomo , Caciolli Francesca , Fava Carmen
Published: August 2020

Discontinuation of tyrosine kinase inhibitors (TKI) is the main goal today in the field of Philadelphia positive chronic myeloid leukemia (Ph + CML) and the criteria to attempt the interruption of therapy are well defined and rely on the possibility to regularly monitor the BCR-ABL1 transcript. Patients harboring atypical transcripts are automatically excluded from protocols due to the absence of a standardized method of quantification of their minimal residual disease (MRD). We report here the outcome of 6 patients with atypical transcripts with a long follow up whose MRD was followed in three cases with digital PCR during their treatment free remission (TFR).
Guest Editor: G. Castaman GENE THERAPY FOR HEMOPHILIA: FACTS AND QUANDARIES IN THE 21ST CENTURY
Authors: Doshi Bhavya S , Arruda Valder R , Arruda Valder R
Published: August 2020

Therapy for hemophilia has evolved in the last 40 years from plasma-based concentrates to recombinant proteins and, more recently, to non-factor therapeutics. Along this same timeline, research in adeno-associated virus (AAV) based gene therapy vectors has provided the framework for successful early phase clinical trials initially for hemophilia B (HB) and now for hemophilia A. Successive lessons learned from these early pivotal HB trials have paved the way for current advanced phase trials. Nevertheless, questions linger regarding 1) the optimal balance of vector dose to transgene expression, 2) amount and durability of transgene expression required, and 3) long-term safety. Some trials have demonstrated unique findings not seen previously regarding transient elevation of liver enzymes, immunogenicity of the vector capsid, and loss of transgene expression. This review will provide an update on the clinical AAV gene therapy trials in hemophilia and address the questions above. A thoughtful and rationally approached expansion of gene therapy to the clinics would certainly be a welcome addition to the arsenal of options for hemophilia therapy. Further, the global impact of gene therapy could be vastly improved by expanding eligibility to different patient populations and to developing nations. With the advances made to date, it is possible to envision a shift from the early modest goal of simply increasing life expectancy to a significant improvement in quality of life by reduction in spontaneous bleeding episodes and disease complications.
COVID‐19 post hematopoietic cell transplant, a report of 11 cases from a single center.
Authors: Adam Afadil
Published: August 2020

In late 2019 the coronavirus disease‐2019 (COVID‐19) pandemic caused by SARS Coronavirus 2 (SARS‐CoV‐2) started in Wuhan, China. Cancer patients are immunosuppressed from their disease and the therapy they receive.Hematopoietic cell transplant (HCT) recipients are a subgroup of patients that are severely immunocompromised and may be at an even higher risk of a complicated course during this infection.We herein report the outcomes and course of 11 sequential cases of HCT recipients infected by SARS‐CoV‐2 treated in our center.The patients age ranged from 17 to 60 years, the duration from transplant to infection ranged from day +5 to 192 months, 6 patients were post allo-HCT, 4 post auto-HCT and one had both allo and auto-HCT. The presenting symptoms were not different from other viral illnesses. The majority had mild COVID-19 stage, while 3 had moderate stage on presentation. None of the patients required oxygen supplementation nor mechanical ventilation.
Immunotherapy in Nonsmall Cell Lung Cancer (Basket of Choices)
Authors: Raj Abhishek
Published: August 2020

The advent of immunotherapy has changed the landscape of lung cancer management over the past few years. Once a uniformly fatal disease with limited therapeutic options, the physicians now have a myriad of options to choose from while offering therapy to a patient of metastatic nonsmall cell lung cancer.
A Large Cervical Immature Cystic Teratoma in a New-Born-Simulating Lymphatic Malformation
Authors: Jain Prashant , Prasad Ashish , Prasad Aparna , Jain Sarika
Published: August 2020

Cervical teratomas are rare and challenging tumors. Although most are benign in nature, there location near vital neck structures can cause significant morbidity. Sometimes, making a diagnosis can be a challenge, especially when it is purely cystic and closely resembles lymphatic malformation.
Takatsuki Syndrome – Not Really a Polyneuropathy, Organomegaly, Endocrinopathy, M-spike, and Skin Change!!!
Authors: Vineeth Vashe Keshava , Shetty Vijith
Published: August 2020

Polyneuropathy, organomegaly, endocrinopathy, M-spike, and skin changes (POEMS) is a rare multisystem disorder, with its prevalence in India being 1 in 330,000. It is a demyelinating neuropathy accompanied by dermatoendocrine syndrome. The cause of POEMS is unknown. The diagnosis of POEMS syndrome requires two mandatory criteria plus more than one major and more than one minor criterion. A middle-aged male with no known comorbidities from South India presented with complaints of burning micturition, increased frequency of micturition, and pain in the abdomen for 3 weeks. The patient was evaluated earlier at another center with a rise in serum creatinine from 1.9 to 2.9 mg/dl within a span of 3 days. The patient had pleural effusion, hypercalcemia, renal failure, and splenomegaly with lytic lesions. Due to the presence of typical skin lesions with polyneuropathy, workup for POEMS was carried out. Positron-emission tomography scan and vascular endothelial growth factor levels were checked and fulfilled the criteria. Early treatment was initiated, and POEMS has a good prognosis. As POEMS is very rare, early diagnosis improves the outcome.
The Efficacy and Safety of Plerixafor in Hematopoietic Stem Cell Mobilization in Patients with Non-Hodgkin Lymphoma, Multiple Myeloma, and Hodgkin Lymphoma Who Failed Mobilization with Granulocyte-Colony-Stimulating Factor Alone: A Single-Center Experience
Authors: Badarkhe Girish , Naik Radheshyam
Published: August 2020

Plerixafor is a CXCR4 antagonist which is administered along with granulocyte-colony-stimulating factor (G-CSF) to mobilize hematopoietic stem cells in patients with Non-Hodgkin lymphoma (NHL) or multiple myeloma (MM), who failed the mobilization with G-CSF alone.

This was a single-center, retrospective study of the efficacy of the plerixafor and G-CSF in 32 patients with NHL (n = 11), MM (n = 11), and Hodgkin lymphoma (HL) (n = 10) who failed mobilization with G-CSF alone.

A median number of 1.21 × 106, 1.32 × 106, and 6.73 × 106 CD34 + cells were mobilized in patients with MM, NHL, and HL, respectively. Overall, 31 (96.8%) patients mobilized more than 2 × 106 CD34 + stem cells and 21 (33.75%) patients mobilized more than 5 × 106 CD34 + stem cells. All 32 (100%) patients underwent hematopoietic stem cell transplantation. There were no adverse drug events reported.

This retrospective study shows that plerixafor is an effective and safe mobilization agent in patients with NHL, MM, and HL who have failed mobilization with G-CSF alone.
An Unusual Case of Acute Myeloid Leukemia with t(8:21) Presenting with Hypereosinophilia Showing Dysplastic Features
Authors: Singh Pragya , Aggrawal Meetu , Dawson Leelawathi , Singh Amitabh
Published: August 2020

Acute myeloid leukemia (AML) with specific genetic abnormalities is a clinically, biologically, and prognostically distinct category with some of the entities in it displaying characteristic morphology. AML with t(8:21) is one such subtype carrying favorable prognosis with specific blast morphology. Eosinophilia, characteristically, has been described till date in AML with inv (16); however, hypereosinophilia with prominent dysplastic features has yet not been seen with any AML subtype. We report the case of an 8-year-old child presenting with massive splenomegaly, hypereosinophilia, and low marrow blast percentage. The initial clinical and hematological impression was that of a chronic myeloproliferative neoplasm, which was later diagnosed as AML with t(8:21) with the help of cytogenetic studies. The case report highlights the unusual and extremely rare presentation of this AML subtype and the importance of cytogenetic studies in definite categorization, especially in cases with overlapping morphological and immunophenotypic findings.
Cerebral Sinus Venous Thrombosis in Indian Pediatric Patients With Acute Lymphoblastic Leukemia: Incidence, Risk Factors, and Outcome
Authors: Garg Akanksha , Kashyap Rajesh , Lal Hira , Mishra Prabhakar
Published: August 2020

Cerebral sinus venous Thrombosis (CSVT) is a rare complication of acute lymphoblastic leukemia (ALL) treatment, with an incidence rate ranging from 1.1% to 2.9%. Steroids and L-asparaginase (LASP) are the major risk factors.

The aim of this study was to find the incidence rate and risk factors for CSVT in our patients. Ninety-two pediatric ALL diagnosed and treated with ALL-Berlin–Frankfurt–Munster-95 protocol over a period of 5 years (2013–2017) were the subject of the study. Six (6.5%) patients developed CSVT during their therapy and were further analyzed.

Six (five males and one female) patients had a CSVT event. The mean age at presentation was 13.5 ± 4.1 years. CSVT event occurred during the induction/re-induction phase of chemotherapy. The superior sagittal sinus was the most frequent site of thrombosis. The timing of CSVT was related to using of LASP and steroids. High-risk disease was associated with an increased risk of thrombosis. Infection and dehydration were other important risk factors. No association was observed between the risk of CSVT and age, sex, immunophenotype, and white blood cell count. All the patients were treated with low-molecular-weight heparin and one patient developed heparin-induced thrombocytopenia. No death occurred due to CSVT.

The Incidence of CSVT was 6.5% in our study which is significantly high but comparable with studies from other Asian countries. It is, therefore, important to be vigilant for the detection of CSVT during treatment of ALL and initiate the appropriate treatment to prevent adverse events.
Validation of Superiority of p40 over p63 in Differentiating Squamous Cell Carcinoma and Adenocarcinoma Lung
Authors: Thamtam Vamshi , Uppin Shantveer , Hui Monalisa , Kumar N , Bhaskar K , Bala Stalin , Sadashivudu G , Paramjyothi G
Published: August 2020

In this era of targeted therapy, it is important to distinguish the various subtypes of nonsmall cell lung carcinoma (NSCC). Diagnosis based on morphology alone is challenging in poorly differentiated carcinomas and core biopsies. Immunohistochemistry (IHC) helps in specifying the lineage for the subtype of NSCC. Till date, p63 is the most frequently used and sensitive marker for squamous cell carcinoma (SQCC). However, it is not specific and stains a subset of adenocarcinoma (ADC). Thus, a more reliable and specific marker is required for the diagnosis of SQCC.

The objective of the study was to validate the diagnostic utility of p40 over p63 in differentiating pulmonary SQCC from ADC and NSCC-not otherwise specified (NOS).

A total of 123 cases of NSCC were initially reviewed and subtyped blinded to the results of IHC. This was followed by a review of IHC slides which included p63, p40, thyroid transcription factor 1, Napsin-A, cytokeratin (CK) 5/6, and CK7.

There were 64 ADC, 19 SQCC, and 40 NSCC-NOS. IHC helped to confirm the morphological diagnosis in 62/64 ADCs and19/19 SQCCs. IHC classified the cases of NSCC-NOS into NSCC favoring ADC – 12 cases, NSCC favoring SQCC – 10 cases, and NSCC favoring AD-SQCC – 4 cases. Both p63 and p40 showed near equal sensitivity for SQCC (100% and 97%, respectively), whereas p63 showed far lower specificity when compared to p40 (51.3% vs. 100%).

The present study confirms and validates that p40 is equally sensitive but highly specific than p63 in detecting SQCC. Hence, we recommend the routine use of p40 instead of p63 for the definite categorization of NSCC of the lung.
Impact of Demographic Traits and Personality Traits of Investors on Their Risk-Bearing Capacity: A Study with Special Reference to Investors of Kerala
Authors: K Athira , Kakkakunnan Mohamed Kutty
Published: August 2020

Investment decisions form a major part of every individual’s life. Behavioral finance which puts forward a new dimension in the field of finance recognizes that investment decisions are made after considering numerous psychological, economical and social factors. One of the important criteria considered while making any such decision is the risk. It includes uncertainties associated with the investment opportunity as well as the investors’ risk-bearing capacity. Investors’ risk-bearing capacity is in turn determined by numerous other aspects. An effort is made here to determine whether the risk-bearing capacities of investors are influenced by the demographic factors and personality traits. 120 investors of Kerala State were selected as the sample for this purpose. Analytical results indicated that the risk-bearing capacity is dependent on gender, occupation, and monthly income of the investors. Further, it was noticed that those who have low neuroticism scores and high scores in agreeableness, extraversion, and conscientiousness took higher risks compared to others. This indicated that neuroticism trait was found to have a negative correlation with risk-bearing capacity whereas; agreeableness, extraversion, and conscientiousness were found to have a positive relation. The study concluded that factors like demography and personality have a strong influence on an investor’s risk-bearing capacity.
Aprendizagem Matemática por meio da Componente Curricular Desenho Geométrico: algumas considerações tangíveis
Authors: Da Conceição Jefferson Correia
Published: August 2020

Este artigo apresenta algumas reflexões acerca de estudos envolvendo os componentes curriculares Desenho Geométrico e Matemática a partir das atividades docentes num contexto acadêmico em sala de aula com licenciandos em Matemática. A pesquisa configura-se como bibliográfica e de campo. Os dados foram analisados por meio da leitura de bibliografias específicas, observações e dos depoimentos dos licenciandos. Os resultados iniciais apresentaram percepções relevantes para efetivação dos estudos, apesar dos licenciandos pesquisados terem evidenciado inicialmente interlocuções limitadas entre as componentes curriculares citadas. Concluiu-se que, mediante os estudos a respeito da aprendizagem Matemática por intermédio do Desenho Geométrico, que é possível dinamizar, motivar e envolver muito mais os licenciandos, entendendo-se tais articulações entre as componentes mencionadas como motivação, ponto de partida, suporte e estímulos para os licenciandos, sobretudo, no que tange ao conhecimento matemático, com uma tessitura mais dinâmica, ativa e prazerosa, mesmo com a necessidade de ajustes e melhorias ao longo do processo, que se entende, como natural.
Initial Conservative Management of Exomphalos Major with Gentian Violet
Authors: Mitul Ashrarur Rahman , Ferdous K M N
Published: August 2020

Aim: The purpose of the study was to assess the results of topical use of gentian violet (GV), among the babies with exomphalos major in our institute. Methods: The study was carried out retrospectively in a tertiary care hospital during the pe­riod from 2005 to 2010 inclusive. Exomphalos patients were classified as major if diameter was >5 cm and/or had liver in the sac as content. These patients were initially preferentially treated conservatively with topical 1% GV over the sac resultig a ventral hernia to be re­paired later. Results: A total of 84 exomphalos patients were admitted during the study period. Among them, 37 neonates (26 males and 11 females) had exomphalos major (EM). Ten of them were prenatally diagnosed. The mean gestational age at delivery was 35 weeks, and mean birth weight was 2.1 Kg. Mean age at presentation was 3.7 days. Thirty (81%) had other associated anomalies, mostly cardiac (66.6%) and pulmonary (46.6%). Ten patients with EM needed early operation because of ruptured sac, and other anomalies. There were 2 pre­operative and 8 postoperative deaths in this subgroup. Twenty seven patients were treated conservatively, among these 4 died of overwhelming sepsis. Remaining 23 patients left the hospital with a ventral hernia planned to be repaired at 1 year of age. Overall mortality in our series was 37.83%. Conclusion: Initial conservative treatment of the sac with GV results in satisfactory outcome for infants with EM who cannot undergo immediate closure.
Influence of TTAB/14-S-14 Micelles on the Rate of the Condensation between Ninhydrin and Mercury-Dipeptide Complex in Absence and Presence of Salts and Organic Solvents: A Kinetic Approach
Authors: Saeed Adel A. M. , Salem Taher A. A. , Akram Mohammed
Published: August 2020

The interaction of mercury(II)–glycyl-L-alanine [Hg(II)–Gly-L-Ala]+ complex with ninhydrin has been studied kinetically both in aqueous as well as micellar media (cationic conventional/gemini surfactants) using UV-vis spectrophotometer at 70 ºC and a particular pH 5.0. The study was carried out as functions of [Hg(II)–Gly-L-Ala]+, [ninhydrin], [surfactant] [salts], and solvents (%v/v). The first-order-rate is observed concerning [Hg(II)–Gly-L-Ala]+, whereas fractional-order-rate dependence for [ninhydrin]. It has been found that 14-s-14 geminis enhance the rate of reaction more effectively than related cationic conventional surfactant tetradecyltrimethylammonium bromide (TTAB). The effect of additives such as salts (inorganic/organic) and organic solvents on the rate was also investigated. The reaction rate was explained in terms of the modified pseudo phase model (considering the association/adsorption of both the reactants on the micellar surface) and changes in micellar morphology occurring at higher [geminis]. The Eyring equation is valid for the reaction over the range of temperatures used. Various thermodynamic parameters and binding constants between reactants with the micelles have been evaluated.
Polyphenols/Flavonoids Analysis and Antimicrobial Activity in Pomegranate Peel Extracts
Authors: Abdu Omnia Hussein , A. M. Saeed Adel , Fdhel Taha Abubaker
Published: August 2020

The use of plants still plays a vital role to establish the basic health requirements in developing countries. The extracts of P. granatum and its compounds have shown antimicrobial activity. This study showed that the acetone (125.36±0.01 and 70.5±0.01) extract contained the highest amount of total polyphenols (TPPC) and total flavonoids content (TFC) respectively compared to methanol (105.6±0.005 and 20.99±0.004) extract while methanol extract content was higher than ethanol (94.14±0.02 and14.48 ±0.005). The aqueous extracts content was the less one (83.17 ± 0.003 and 10.65±0.003). When study the antimicrobial activity of four different prepared concentrations of four pomegranate peel extracts against microorganisms including two Gram-positive bacteria [P. aeruginosa and S. aureus], one Gram-negative bacteria [A. baumannii] and Candida parapsilosis. The result shown the antimicrobial activity of acetone extract on all microorganisms the highest value followed by methanol, ethanol, and aqueous extract activity. Besides, the activity of all extracts was good excepted aqueous extract has low antimicrobial activity against S. aureus.
Antibacterial Activity of Aloe Lanata and Aloe Vacillanis Plant Extracts
Authors: Khardesh Amani Ahmed F. , Hadi Hitham Qasem M. , Ali Khaled Saeed
Published: August 2020

This study was conducted to evaluate the antibacterial effect of the aqueous and Methanolic extracts of Aloe Lanata and Aloe Vacillanis. Using agar diffusion method, three different concentrations of Aloe extracts were evaluated on Staphylococcus aureus, Escherichia. coli, Pseudomonas aeruginosa, and to compare the effectiveness of extracts with some antibiotics  (Ampicillin: Amp, Erythromycin: Erytho, Gentamycin: Genta).The extracts showed that there was a different effect on the bacterial species according to the type and concentration of the plant extract as well as the inhibitory response to the bacterial species. The aqueous and alcoholic extract of A. lanata is more potent than A. vacillanis extract. In comparison to the type of extract, the alcoholic extract of A. lanata was more effective than the aqueous extract, while the aqueous extract of the A. vacillanis showed higher efficacy than the alcoholic extract. Both extracts had the most substantial effect on both E. coli and P. aeroginosa and were less effective on S. aureus. Antibacterial efficacy of studied plant extracts showed better efficacy than the antibiotic (Ampicillin, Erythromycin) on Staphylococcus aureus and E. coli.
Evaluation of Some Hematological and Serological Changes in Dengue Patients of Lahj-Yemen
Authors: AL-Samadi Manal Mohamed , Ali Khaled Saeed
Published: August 2020

The present study aimed to evaluate the changes in WBC and platelet count and detection of NS1 antigen, IgM and IgG antibodies in dengue patients. There were 103 confirmed cases of dengue including 49(47.6%) females and 54(52.4%) males. The WBC count was less than (2000 /μl) in 16 cases and was ranging between (2000-4000 /μl) in 44 cases. The platelets count decreased to <50000/μl in 4 (3.9%) of cases, <100,000/μl (50,000- 100,000/μl) in 14 (13.6%) of cases, and were between (100000-150000/ul) in 12 cases. About 83 (80.6%) patients were positive NS1 antigen, and 4 (3.9%) patients had IgM antibodies against dengue. Remaining 16 (15.5%) had both IgM and IgG antibodies against dengue. The identification of NS1 antigen, WBC and platelet count can be used as predictors of dengue infection.
التّقدير الكمّي للكوليسترول الكُلّي في بعض ألبان الأسواق اليمنيّة
Authors: Saeed Adel A. M. , Salem Taha Abu-Bakr Fahdel , Al-Saidi Fares Saif Salem
Published: August 2020

هدفت الدّراسة إلى تقدير الكوليسترول كمّيّاً في بعض الألبان المباعة في الأسواق اليمنيّة باستخدام الكروماتوجرافيا السّائلة فائقة الضّغط (HPLC). جمعت ثلاث عشر عيّنة بطريقة عشوائية من بعض الأسواق المحلّيّة وبعض المزارع الحيوانيّة (لمحافظتي عدن وأبين) وجهّزت للتحليل. تراوحت مستويات الكوليسترول بين (0.34-22.8 mg/100g). كان ترتيب المحتوى الكوليسترولي للعيّنات وفق المجاميع التّالية: الحليب الخام الطّازج كامل الدّسم الحيواني > الألبان التّجاريّة كاملة الدّسم الحيواني > الألبان التّجاريّة منزوعة الدّسم الحيواني والمضاف إليها دهن نباتي
CLINICAL FEATURES AND HEMATOLOGICAL PARAMETERS IN SOME CHIKUNGUNYA PATIENTS, YEMEN
Authors: Ali Eman Abdo , Ali Khaled Saeed , Alsubaihi Riad Mohamed
Published: August 2020

During march – May 2020, chikungunya (CHIK), an arboviral infection, has spread throughout the all area of Aden and Lahj governorate, infecting thousands of people.The study investigated haematological parameters and Clinical features of CHIK virus infected patients attending outpatient clinic at Al-shafa and Algamaheer medical center, Aden and Lahj, Yemen. 50 selected patients within the age of 14- 60 years were involved in the study according to the clinical features. The most common feature of the CHIKV infection was arthralgia and high fever. Other clinical manifestations reported as, headache, joint pain, redness of joints , swelling of joints vomiting and Fatigue Blood samples were collected and analyzed using Sysmex automated haematology analyzer for CBC test.Results showed the emergence of lymphopenia (15.7 ± 6.18%) , neutrophils (73.8 ± 6.98%) and the complete white blood cell (WBC) counts was 4.8 ± 1.4 103/μL in patients. The platelets (PLT) counts ranged from 92-244 103/μL (mean: 160 ± 47.4x103/μL). The hemoglobin decreased in 30 % of cases and was about (10 ± 1.2 g/dl) in children. By day 5 of illness the neutrophil and lymphocyte count had recovered to normal range, but the arthralgia and joint pain was continued for weeks. In addition of Clinical features, the neutrophils and lymphopenia was the main hematological indices of CHIK, in lack of CHIK antigen detection
SOSIALISASI PENGGUNAAN APLIKASI ZOOM MEETING DAN GOOGLE CLASSROOM PADA GURU DI SDN 17 MATA AIR PADANG SELATAN
Authors: Suhery Suhery , Putra Trimardi Jaya , Jasmalinda Jasmalinda
Published: August 2020

Tujuan dari kegaitan pelatihan agar guru di SDN 17 Mata Air Padang Selatan bisa melakukan pembelajaran daring secara online melalui rumah tanpa tatap muka langsung dengan siswa.Metode  yang  dipilih  dengan  cara  memberikan pelatihan.  Hasil  dari  kegiatan  pengabdian  masyarakat  ini adalah  panduan  praktis  dan  sederhana  berupa  pedoman  bagi  guru di SDN 17 Mata Air Padang Selatan untuk paham dan mengerti menggunakan aplikasi zoom meeting dan google classroom.
Modern stratagems for renewing the competitive environment of construction development
Authors: D. A. Ryzhakov  , Kondratsky V.O.
Published: August 2020

The company can maintain its competitive advantage through two the kinds of abilities - distinctive and replicable - and the unique combination of these that the organization creates to achieve synergy. The determining factor is the importance of the company's strategy. New concepts of competitiveness do not deny the importance traditional factors such as company size, assortment policy, price differentiation and low costs. At the same time, the special importance of new factors - key competencies, brand value, reputation, i.e. resources that are intellectual.
Ways to increase the efficiency of the marketing activities of the advertising enterprises
Authors: Zolotarova  Valentina
Published: August 2020

The purpose of the article is to identify ways to improve the marketing activity of advertising companies.

In the course of the research were used: general scientific methods, in particular: systematic approach - to identify and justify the global trends in the development of advertising services; expert survey method - to determine the priorities of advertising companies and promoters of promotional products among these two groups of respondents in the process of interaction; systematic method - to determine the main directions of increasing the efficiency of the enterprise advertising industry. According to the results of the research, the author identified the main trends that will prevail in the world and domestic advertising sphere in the coming years, as well as the main directions of improving the efficiency of the advertising industry. The practical significance of research results is that they can be used by advertising companies to improve their own performance, create new sustainable competitive advantages, find strategic opportunities, and more.