bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Handover Control Parameters on Handover Performance in 5G and beyond Mobile Networks
Authors: Alraih Saddam , Nordin Rosdiadee , Shayea Ibraheem , Abdullah Nor Fadzilah , Abu-Samah Asma , Alhammadi Abdulraqeb
Published: March 2022

Mobility management is essential in mobile communication networks to provide a smooth connection during users’ mobility. Handover control parameters (HCPs), such as handover margin (HOM) and time-to-trigger (TTT), are major and essential factors in mobility management that must be defined carefully to make efficient handover (HO) procedures. Their impact becomes more critical with the deployment of fifth-generation (5G) mobile networks and beyond (B5G). This is due to the different characterizations of next mobile networks, such as the use of millimeter-wave (mmWave) bands, the ultradense deployment of small base stations (BSs), large mobile connection traffic growth, and other more critical factors. The case becomes more sensitive with the high mobility speed scenarios. This study proposes different HCP system settings to be investigated and analyzed over B5G networks. They will be investigated with various mobile speed scenarios to illustrate their impact on the network performance. Various key performance indicators (KPIs) are considered to evaluate and validate system performance, such as reference signal received power (RSRP), HO probability (HOP), HO ping-pong (HOPP), radio link failure (RLF), HO interruption time (HIT), and HO failure (HOF). Results show that the various system settings provide different and significant impacts on the performance of B5G networks. Furthermore, the setting of HCP1 obtained the best performance in RSRP and RLF with -69.7 dBm and 4.8%, respectively, while the optimum performance of HOPP, HIT, HOP, and HOF is achieved in the HCP6 setting with 0%, 0.02 ms, 0.05%, and 0%, respectively. Moreover, the overall outcome of all HCP settings is 54.94%. These results indicate a tradeoff between RLF and HOPP with various HCP settings in B5G mobile networks. Thus, the HCP system settings must be adjusted carefully considering other factors, such as mobile environment and use case.
Accurate Recognition Method of Continuous Sports Action Based on Deep Learning Algorithm
Authors: Zhengfeng Huang
Published: March 2022

In order to improve the recognition effect of continuous sports action, an accurate recognition method of continuous sports action based on deep learning is proposed. The convolution neural network is used to predict the key points and center vector of human body in grid mode, and the key points of human body are grouped according to the distance from the key points of the human body to the center of human body, so as to obtain the sequence diagram of sports posture, input the posture sequence diagram of sports action in the deep learning network, and apply the best strategy of continuous action recognition obtained in the deep learning training stage to the accurate recognition of continuous sports action. The position of the rectangular frame of the attitude instead of the target attitude is predicted online by the convolution neural network, and the recognition is completed when the attitude stops. The experimental results show that this method can effectively recognize continuous sports actions in real time. The expected average overlap rate of different video attributes is high, which has better recognition effect. At different position error thresholds, it has high recognition accuracy.
Biological Breakdown of Sports in Athletics Based on Multimedia Image Acquisition Techniques
Authors: Sun Peng , Zhang Biyu , Chen Qiaoling , Guo Jianbang
Published: March 2022

This paper provides an in-depth analysis and study of the decomposition of sports biology of athletics events through multimedia image acquisition techniques. The proposed design uses SOPC hardware-software collaboration technology, which makes full use of the parallelism of hardware as well as the flexibility of software to essentially improve the speed of image processing and greatly improve the efficiency of image processing. The high speed and parallelism of hardware are used to realize the image acquisition part with high timing requirements and the preprocessing algorithm with a large number of operations and strong repetition, in addition to the difficulties of many initialization configuration parameters of each peripheral. Additionally, the need for frequent adjustment of peripheral working parameters is solved by making full use of the scalability and flexibility of software, and the control signals output by software can coordinate the work of each hardware module to ensure that each module of the system cooperates. It is also possible to coordinate the work of each hardware module through the control signal output from the software to ensure that each module of the system cooperates and operates in an orderly and efficient manner and provides the possibility of realizing a higher level of the image processing algorithm. The system includes four main factors: swinging action, supporting action, vacating action, and speed rhythm. Based on this system, 14 key kinematic indicators were selected to reflect the technical status of the youth walkers. The landing angle decreased with the increase of speed, and the landing technique was insufficient; it had better control of the large and small arm angle, and their stride width was open, while the other four athletes showed increased tension in the hip joint and upper limb with the increase of walking speed, as well as the wrong action of forward and internal rotation of the large and small arms.
On Vertex Degree-Based Topological Indices for Fixed Branching Vertices of Trees
Authors: Hanif Muzamil , Bhatti Akhlaq Ahmad , Javaid Muhammad , Alam Md Nur
Published: March 2022

The Gourava indices and hyper-Gourava indices are graph invariants, related to the degree of vertices of a graph

G

. Let

T

n
,
b

denote the collection of all chemical trees with

n

vertices where

b

denotes the number of branching vertices,

1
≤
b
<

n
−
2

/
2

. In the current paper, maximum value for the abovementioned topological indices for different classes

1

T

n
,
b

and

2

T

n
,
b

of

T

n
,
b

is determined and the corresponding extremal trees are characterized.
A Cloud Computing-Based Intelligent Forecasting Method for Cross-Border E-Commerce Logistics Costs
Authors: Li Yanting
Published: March 2022

Aiming at the problems of poor forecasting effect and low accuracy and low efficiency in current cross-border e-commerce logistics cost prediction methods, a cloud computing-based intelligent method for cross-border e-commerce logistics cost prediction is proposed. Analyze cloud computing concepts, characteristics, and service models, study cloud computing-related technologies, and train BP neural network algorithms based on BP neural network principles. The BP neural network structure is obtained by determining the number of neurons in the input layer, the number of neurons in the hidden layer, the number of neurons in the output layer, and the activation function of the neural network. Normalize the input data samples of the input layer, and select the initial weight, threshold, and learning rate parameters of the BP neural network to determine the momentum coefficient. This paper uses neural network model combined with Spark cloud computing platform to realize the intelligent prediction of cross-border e-commerce logistics cost. This method has good predictive ability. After a large amount of data input and output relationship training, it has obtained the most suitable model for prediction. The experimental results show that the cross-border e-commerce logistics cost prediction effect of the proposed method is good, and it can effectively improve the accuracy and efficiency of cross-border e-commerce logistics cost prediction.
An Improved Method Research on Graphics and Image Processing System
Authors: Du Zhaofang
Published: March 2022

In the era of high-speed information, with the popularization of network and the rapid development of multimedia communication technology, human society has entered a key new stage of development. Human productivity and living style have been significantly altered as a result of social informatization. The field of computer image processing has also made significant strides recently. Photoshop has evolved into a must-have piece of software for those who work in computer graphics and image processing on a regular basis. It contributes to increased job productivity in the processing of computer visuals and photos because of its extensive functionality, user-friendliness, and humanization. Photoshop is a graphics and image processing technology programme that is very efficient. This software’s image processing function is quite strong, and it is capable of producing graphics and image processing of the highest quality. This technology is widely used in practical work. Professionals are required to operate skillfully and grasp the technology accurately. Photoshop is widely used in current graphics and image processing. While meeting the relevant processing requirements of users, it is also used in various occasions related to image processing.
Peripapillary Nerve Fiber Layer Thickness and Optic Nerve Head Parameters in Patients Recovered from COVID-19: A Longitudinal Study
Authors: Abrishami Mojtaba , Hassanpour Kiana , Hosseini SeyedehMaryam , Shoeibi Nasser , Ansari-Astaneh Mohammad Reza , Emamverdian Zahra , Gharib Bahareh , Amini Nasibeh , Abrishami Majid
Published: March 2022

Purpose. To quantify the longitudinal changes of the optic nerve head (ONH) parameters and peripapillary retinal nerve fiber layer (pRNFL) thickness in patients recovered from coronavirus disease 2019 (COVID-19) using spectral-domain optical coherence tomography (OCT) analysis. Materials and Methods. In an observational longitudinal study, in patients recovered from COVID-19, ONH OCT images were recorded at least two weeks after recovery from the systemic disease as the baseline and after one and three-month follow-up. Ganglion cell complex (GCC) analysis, ONH parameters, and pRNFL thickness changes were measured. Results. A total of 36 eyes from 18 recovered COVID-19 patients including eleven (61.2%) females were studied. The average age was 35.5 ± 7.5 years. The pRNFL thickness in the nasal lower sector significantly decreased from 77 ± 18 μm in the first post-COVID-19 month to 74 ± 10 μm in the third month (

P
=
0.8

). The average, superior, and inferior pRNFL thickness remained unchanged. The average cup volume significantly decreased from 0.27 ± 0.15 mm3 at baseline to 0.19 ± 0.15 mm3 in the third post-COVID-19 visit (

P
=
0.028

). In terms of ONH morphologies including rim, disc and cup to disc area, and the vertical and horizontal ratio, the changes were not significant over the 3-month study period. Focal loss volume and global loss volume values were not changed significantly. Conclusion. Localized defect in the nasal lower sector of pRNFL is observed in 3-month post-recovery from COVID-19. Larger studies with longer follow-ups are required to reveal the exact changes in ONH parameters.
Clinical Observation and Pharmacoeconomic Evaluations of Original Research Drug and Generic Drug Bortezomib in the Treatment of Multiple Myeloma
Authors: Liang Yongchao , Zhu Ying , Zhang Ying , Chen Ziwei , Li Boyang , Liu Aijun , Liu Lihong
Published: March 2022

Background. Multiple myeloma (MM) is one of the hitherto incurable malignant blood tumors. Bortezomib plays an important role in the treatment of MM. Objective. We aimed to compare effectiveness, safety, and pharmacoeconomic evaluations of the original research drug and the generic drug Bortezomib in the treatment of MM, so as to provide a reasonable basis for the selection of drugs in clinical diagnosis and treatment. Methods. A collection of 374 patients with MM were diagnosed and treated with combined Bortezomib in our hospital from July 2019 to January 2020.Two hundred and sixty nine cases met the criteria for inclusion and discharge. According to the different drug manufacturers, divided into the original research drug group (n = 149) and the generic drug group (n = 120). The effectiveness and safety were separately counted, and use the cost-minimization analysis to make the pharmacoeconomic evaluations. Results. Compared with the results of the two groups, there was no statistical difference between the two groups of treatment efficacy or adverse reaction rates (

P

 > 0.05). The average daily cost of the original research drug group was 2954.38 Chinese yuan (CNY), the average treatment cost per cycle was 32967.69 CNY, the average daily cost of the generic drug group was 2697.29 CNY, and the average treatment cost per cycle was 29129.57 CNY. The price of the generic drug group is lower than the original drug group, and there was a statistical difference between the two groups (

P

 < 0.05). Conclusion. There was no difference between the two groups of effectiveness or safety, and the generic drug is more economical in the treatment.
Consistency Analysis of CTLM Imaging and Mammography in the Diagnosis of Breast Tumor Lesions
Authors: Song Zhangjun , Wang Huxia , Feng Xiaorui , Yang Xiaomin , Han Pihua , Zhao Jing
Published: March 2022

Objective. To analyze the consistency of preoperative CTLM imaging in the diagnosis of breast cancer lesions and postoperative pathological examination. Methods. The clinical data of 225 patients with breast tumor in our breast surgery department were collected. All patients underwent mammography, CTLM, and pathological examination. To analyze the image characteristics of breast CTLM imaging, calculate the diagnostic efficacy of CTLM imaging for breast tumors, and compare the image characteristics of CTLM imaging for benign and malignant tumors. Results. (1) Postoperative pathological examination showed that 136 cases (60.44%) of lesions were benign tumors, and 89 cases (39.56%) were malignant tumors. (2) The “spokes distribution” of normal breast CTLM images was interrupted. In the 3D reconstructed images, the morphology of the abnormal angiogenesis area is mostly irregular nonbanded structure, which is manifested as slab structure, spindle structure, spherical structure, diverticulum structure, inverted conical structure, rings structure, branched structure, and dumbbell structure. (3) The detection rate of breast tumor by CTLM imaging was 84.44%. The specificity and coincidence rate of CTLM imaging were higher than that of mammography (P < 0.05). (4) The features of CTLM imaging images of breast malignant tumors are mostly bright white locally, with irregular edges and obvious attenuation of laser signal, and the reconstructed shape of 3D images is mostly like a slab structure. Conclusion. CTLM imaging can provide related information of neovascularization in breast cancer lesions, which is basically consistent with pathologically confirmed lesions.
Rehabilitation Treatment of Muscle Strain in Athlete Training under Intelligent Intervention
Authors: Qiao Yu , Zhang Lei , Zhang Bin
Published: March 2022

With the development of artificial intelligence technology in the medical field, clinical trials using artificial intelligence as an intervention method are constantly emerging. This article mainly introduces the intervention of artificial intelligence and emotional intelligence on the rehabilitation of athletes’ muscle strains. Among them, artificial intelligence and emotional intelligence are a brand-new nursing intervention method. This article compares conventional rehabilitation therapy with these two new types of intelligent interventions to explore the effects of artificial intelligence intervention and emotional intelligence intervention in the rehabilitation of athletes. The experimental results show that the average number of muscle restrains under the intervention of artificial intelligence is 4.1 times, the average restrain rate of muscles is 27.7%, and the average recovery degree of athletes is 94.7%. The average SPB score under emotional intelligence intervention was 56 points. Artificial intelligence interventions can enhance rehabilitation through advanced technology, and emotional intelligence interventions can provide emotional support to effectively improve treatment outcomes and quality of life.
Pharmacological Study on Total Glycosides of Xiebai Protecting against Depression Model
Authors: Zhao Hui , Jiang Meiqiong , Miao Mingsan
Published: March 2022

Objective. To observe the effect of total glycosides of Xiebai on chronic unpredictable stimuli in rats. Changes of serotonin (5-HT), dopamine (DA), norepinephrine (NE), serum corticosterone (CORT), adrenocorticotropic hormone (ACTH), organ index, and histopathology in brain tissue, to explore the treatment and characteristics of total white glucosides in depression model, were prepared by different stimuli in 21 days. Methods. Depression models were replicated by 21 days of chronic mild stimulation in rats. Finally, the levels of CORT and ACTH in the serum of rats with depression model and the levels of NE, DA, and 5-HT in brain homogenates were determined. The thymus and spleen wet weight of each group were measured, and the organ index was calculated. The thymus and pituitary were observed under the light microscope. Pathological changes of the hypothalamus, adrenal gland, and spleen and behavioral indexes of rats in each group were determined. Results. The results of the experiment showed that 21 days of chronic unpredictable stimulation significantly improved the behavioral response of the model group, and the levels of corticosterone and adrenocorticotropic hormone in the serum and the indicators in the brain homogenate significantly changed, affecting the relevant tissues. The index changes and the results of the combination can prove that this modeling method can be used for the preparation of depression models. The total white glucoside group can significantly improve the above effects, demonstrating that total glucosides of glucoside have a good therapeutic effect on the rat model of depression. Conclusion. The chronic unpredictability of the total dose of Xiebai glycosides can significantly improve the levels of NE and DA and the levels of serum CORT and ACTH in the brain homogenate of depressive model rats and improve the immune function of the body.
Using Two Detection Methods to Observe the Changes and Significance of Free Light Chain in Serum and Urine in Patients with Renal Insufficiency
Authors: Xu Lengnan , Zhao Ban , Sun Ying , Wang Songlan , Chen Xianguang , Mao Yonghui
Published: March 2022

Background. Free light chains κ and λ (FLC κ, FLC λ) are of great significance in diagnostic and monitoring monoclonal gammopathy. Freelite and N‐Latex methods are two common monitoring methods at present. But the two meanings are not completely equivalent, especially for patients with renal insufficiency. We analyzed the changes of serum and urine FLC in renal insufficiency patients without monoclonal gammopathy and the clinical significance of these changes. Methods. This study is an observational study. Patients ≥ 18 years old, who met the diagnostic criteria of chronic kidney disease (CKD), excluding monoclonal gammopathy, were selected. Fasting serum and 24‐hour urine were taken to detect serum FLC κ, serum FLC λ, SCr, serum β2‐microglobulin, urinary FLC κ, urinary FLC λ, urinary α1‐microglobulin, and urinary β2‐microglobulin. Results. There was a good correlation between the two methods for determining serum/urinary FLC. No matter serum or urine, FLC showed a good correlation with renal function by the N‐Latex method, but not by the Freelite method. Under the N‐Latex method, FLC κ/λ remained stable, which was basically within the reference range of healthy people and was not affected by renal function. There was a good correlation between FLC detected by N‐Latex and microglobulin in serum and urine. Conclusion. When the concentration of FLC is low, the N‐Latex method is more recommended to monitor FLC. The FLC measured by the N‐Latex method is more closely related to renal function. The ratio of FLC κ/λ determined by the N‐Latex method remained stable within the recommended range.
Deep Seated Lobular Capillary Hemangioma (Pyogenic Granuloma) of the Colon: A Rare Case Requiring Surgery beyond Endoscopic Management
Authors: Park Jaechun , Jung Minjung
Published: March 2022

Background. Lobular capillary hemangiomas typically present as skin or oral mucosa lesions and have rarely been described in unusual sites, including the gastrointestinal tract. Most colonic lobular capillary hemangiomas, either asymptomatic or associated with GI bleeding, have been amenable to endoscopic treatment in literatures. Case Presentation. A 41-year-old woman presented with an incidental colonic mass during a systemic workup after adjuvant chemotherapy for HER2-positive breast cancer. Abdominal computed tomography revealed a deep seated colonic mass in the splenic flexure. An endoscopic strip biopsy was attempted for differential diagnosis of this lesion, but uncontrolled bleeding occurred, and an emergency surgery was eventually performed. Microscopic examination showed lobular capillary hemangioma involving full thickness of the colonic wall with mucosal ulceration. Conclusions. Colonic lobular capillary hemangioma is a benign vascular proliferation but is a candidate in differential diagnosis of benign or malignant tumors. Furthermore, the exceptional case may be deep seated and require more invasive surgery, unlike most cases of colonic lobular capillary hemangioma that can be treated with endoscopic modality.
METTL3 Accelerates Breast Cancer Progression via Regulating EZH2 m6A Modification
Authors: Hu Shaojun , Song Yang , Zhou Yu , Jiao Yu , Li Guopeng
Published: March 2022

We aimed to investigate the bio-functions of METTL3 in promoting breast cancer (BCa) progression via regulating N6-methyladenosine (m6A) modification of EZH2 mRNA. METTL3 levels in 48 cases of BCa and matched paracancerous tissues were detected. In the meantime, METTL3 in BCa patients with different staging or lymphatic metastasis states were examined. Prognosis of the BCa patients was analyzed using Kaplan–Meier estimator. Protein levels of EMT-associated genes and invasive and migratory abilities were evaluated. The binding relationship between EZH2 and METTL3 was analyzed via RIP. Besides, m6A modification of EZH2 mRNA was explored. E-Cadherin level in MCF-7 cells with EZH2 knockdown was tested. Subsequently, ChIP was done to verify the interaction between E-cadherin and EZH2. Regulatory effects of METTL3/E-cadherin axis on EMT and metastasis of BCa were finally determined. METTL3 was upregulated in BCa tissues compared to paracancerous ones. METTL3 was especially higher in T3-T4 BCa or those with lymphatic metastasis. BCa patients expressing high level of METTL3 experienced worse survival. METTL3 was identically upregulated in BCa cell lines. Knockdown of METTL3 in MCF-7 cells attenuated EMT and metastatic abilities. Protein level of EZH2 was downregulated after knockdown of METTL3 in MCF-7 cells, while its mRNA level was not influenced by METTL3. Furthermore, METTL3 was confirmed to interact with EZH2, and m6A modification existed in EZH2 mRNA. Knockdown of EZH2 greatly upregulated mRNA level of E-cadherin, and later, ChIP assay confirmed the interaction between EZH2 and E-cadherin. E-Cadherin could abolish the effects of METTL3 on BCa metastasis and epithelial-mesenchymal transition. METTL3 is upregulated in BCa. It could regulate the protein level of EZH2 through m6A modification to promote EMT and metastasis in BCa cells, thereafter aggravating the progression of BCa.
ProNGF/NGF Modulates Autophagy and Apoptosis through PI3K/Akt/mTOR and ERK Signaling Pathways following Cerebral Ischemia-Reperfusion in Rats
Authors: Li Yanbo , Wu Fengbo , Zhou Muke , Zhou Jie , Cui Shuhui , Guo Jian , Wu Junhao , He Li
Published: March 2022

NGF is involved in the process of autophagy; however, the underlying mechanisms of proNGF/NGF on autophagy in cerebral ischemia-reperfusion (CIR) remain unclear. This study explored the potential pathway of proNGF/NGF in mediating autophagy and apoptosis and thereby contributed to poststroke neurological rehabilitation. In this study, PC12 cell lines and male SD rats were used to simulate CIR; it was found that within 24 h reperfusion, proNGF was the predominant form of Ngf while after 24 h NGF was produced by proNGF transformation. The mature NGF was found to protect neurons against autophagic and apoptotic damage caused by CIR, but proNGF can cause both autophagic and apoptotic neuronal damage. The protective effect of NGF is associated with the activation of the PI3K/Akt/mTOR and ERK pathway and, as well as the change of autophagy-related proteins. On the other hand, proNGF promoted the ERK pathway increasing autophagy and affected the apoptosis-related proteins in vivo and in vitro. These results were also verified in male SD rats with CIR that neurological deficit caused by CIR can be rescued by recombinant and wild-type NGF, and vice-versa by proNGF.
Traditional Chinese Medicine Constitution Identification Based on Objective Facial and Tongue Features: A Delphi Study and a Diagnostic Nomogram for Blood Stasis Constitution
Authors: Meng Yue , Liu Li’an , Zheng Yanfei , Li Lingru , Liu Xing , Qin Junjun , Xia Jing , Cui Diankun , Liang Jinfeng , Li Zhuqing , Li Tianxing , Wu Taotao , Yan Yun , Li Wenle , Zhou Yaoyao , Sun Jianxiang , Hou Shujuan , Wang Qi
Published: March 2022

Objective. The aim of this study was to systematically summarize and form an expert consensus on the theoretical experience of tongue and facial features for the identification of nine types of traditional Chinese medicine (TCM) constitution. Additionally, we sought to explore the feasibility of TCM constitution identification through objective tongue and facial features. Methods. We used Delphi method to investigate the opinions of experts on facial and tongue feature items for identifying TCM constitution. We developed and validated a diagnostic nomogram for blood stasis constitution (BSC) based on objective facial and tongue features to demonstrate the reliability of expert consultation. Results. Eleven experts participated in two rounds of expert consultation. The recovery rates of the two rounds of expert consultation were 100.0% and 90.9%. After the first round, 39 items were screened out from 147 initial items, and 2 items were supplemented by experts. In the second round, 7 items were eliminated, leaving 34 items for 8 types of TCM constitution. The coefficient of variation in the first round was 0.11–0.49 for the 147 items and 0.11–0.29 for the included items. The coefficient of variation in the second round was 0.10–0.27 for the 41 items and 0.10–0.20 for the included items. The W value was 0.548 (

P
<
0.001

) in the first round and 0.240 (

P
<
0.001

) in the second round. Based on expert consultation, we selected BSC as an example and developed and validated a diagnostic nomogram consisting of six indicators: sex, hair volume, lip color-dark purple, susceptibility-facial pigmentation/chloasma/ecchymosis, zygomatic texture-red blood streaks, and sublingual vein-varicose and dark purple. The nomogram showed good discrimination (AUC: 0.917 [95% confidence interval [CI], 0.877–0.956] for the primary dataset, 0.902 [95% CI, 0.828–0.976] for the validation dataset) and good calibration. Decision curve analysis demonstrated that the nomogram was clinically useful. Conclusion. This is the first study to systematically summarize the existing knowledge and clinical experience to form an expert consensus on the tongue and facial features of nine types of TCM constitution. Our results will provide important prior knowledge and expert experience for future constitution identification research. Based on expert consultation, this study presents a nomogram for BSC that incorporates objective facial and tongue features, which can be conveniently used to facilitate the individualized identification of BSC.
Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice
Authors: Heintz Melissa M. , Kumar Ramiya , Maner-Smith Kristal M. , Ortlund Eric A. , Baldwin William S.
Published: March 2022

Increases in traditional serum lipid profiles are associated with obesity, cancer, and cardiovascular disease. Recent lipidomic analysis has indicated changes in serum lipidome profiles, especially in regard to specific phosphatidylcholines, associated with obesity. However, little work has evaluated murine hepatic liver lipidomic profiles nor compared these profiles across age, high-fat diet, or specific genotypes, in this case the lack of hepatic Cyp2b enzymes. In this study, the effects of age (9 months old), high-fat diet (4.5 months old), and the loss of three primarily hepatic xeno- and endobiotic metabolizing cytochrome P450 (Cyp) enzymes, Cyp2b9, Cyp2b10, and Cyp2b13 (Cyp2b-null mice), on the male murine hepatic lipidome were compared. Hierarchical clustering and principal component analysis show that age perturbs hepatic phospholipid profiles and serum lipid markers the most compared to young mice, followed by a high-fat diet and then loss of Cyp2b. Several lipid biomarkers such as PC/PE ratios, PE 38 : 6, and LPC concentrations indicate greater potential for NAFLD and hypertension with mixed effects in Cyp2b-null mice(less NAFLD and greater hypertension-associated markers). Lipid profiles from older mice contain greater total and n-6 fatty acids than normal diet (ND)-fed young mice; however, surprisingly, young Cyp2b-null mice contain high n-6 : n-3 ratios. Overall, the lack of Cyp2b typically enhanced adverse physiological parameters observed in the older (9 mo) mice with increased weight gain combined with a deteriorating cholesterol profile, but not necessarily all phospholipid profiles were adversely perturbed.
Computing Connection-Based Topological Indices of Dendrimers
Authors: Sattar Aqsa , Javaid Muhammad , Bonyah Ebenezer
Published: March 2022

Dendrimers are artificially synthesized polymeric macromolecules composed of frequently branching chains called monomers. Topological indices (TIs) are the molecular descriptors which characterize the topology and help to correlate the distinct psychochemical properties such as stability, boiling point, and strain energy of molecular compounds. TIs are classified on the basis of their degrees, distance, and spectrum. Among these TIs, connection-based topological descriptors have great significance. In this study, we initiate the general expressions to compute multiplicative connection Zagreb indices (MZIs), named as first MZCI, second MZCI, third MZCI, fourth MZCI, modified first MZCI, modified second MZCI, and modified third MZCI of two exceptional dendrimers nanostars, namely, poly (propyl) ether imine (PPIE) dendrimer and polypropylenimine octamin (PPIO) dendrimer. Furthermore, in order to check the superiority of our computed results, a comparative analysis is conducted.
Assessing the Dynamic Resilience of Local Roads: A Case Study of Flooding in Wuhan, China
Authors: Shi Zhenwu , Yang Zifeng , Liu Jie
Published: March 2022

This study proposed a modified metric inspired by the well-applied “resilience-triangle” framework to integrate the resilience concept within the traffic speed. Firstly, for setting the evolving normal functionality, this study added the concepts of robustness loss and rapidity to characterize and compare the recovery processes of local roads and assess the corresponding resilience under different traffic operation conditions. Secondly, these different evolving resilience patterns provide a quantitative benchmark for detecting the links between resilience and traffic operating conditions and exploring its impact on total resilience. Finally, this study simulated and compared the dynamic evolution of the total resilience of local roads, which accurately captured the weak and poorly resilient road locations. Our findings indicated that the proposed metric was quite efficient and accurate in assisting stakeholders to prioritize the transport planning and the retrofit projects of some specific local roads, which could improve the resilience of overall transport system significantly.
Clustering Merchants and Accurate Marketing of Products Using the Segmentation Tree Vector Space Model
Authors: Ding Xuwu , Wu Zhong , Li Meng
Published: March 2022

Using social commerce users as the data source, a reasonable and effective interest expression mechanism is used to construct an interest graph of sample users to achieve the purpose of clustering merchants and users as well as realizing accurate marketing of products. By introducing an improved vector space model, the segmentation tree vector space model, to express the interests of the target user group and, on this basis, using the complex network analysis tool Gephi to construct an interest graph, based on the user interest graph, we use Python to implement the K-means algorithm and the users of the sample set according to interest topics for community discovery. The experimental results show that the interests of the sample users are carefully divided, each user is divided into different thematic communities according to different interests, and the constructed interest graph is more satisfactory. The research design of the social commerce user interest mapping scheme is highly feasible, reasonable, and effective and provides new ideas for the research of interest graph, and the boundaries of thematic communities based on interests are clear.
A New Iterative Algorithm for General Variational Inequality Problem with Applications
Authors: Khan Aysha , Akram M. , Dilshad M. , Shafi J.
Published: March 2022

This study aims at investigation of a generalized variational inequality problem. We initiate a new iterative algorithm and examine its convergence analysis. Using this newly proposed iterative method, we estimate the common solution of generalized variational inequality problem and fixed points of a nonexpansive mapping. A numerical example is illustrated to verify our existence result. Further, we demonstrate that the considered iterative algorithm converges with faster rate than normal

S

-iterative scheme. Furthermore, we apply our proposed iterative algorithm to estimate the solution of a convex minimization problem and a split feasibility problem.
Research on the Current Situation, Causes, and Countermeasures of Primary School Physical Education Teachers’ Health Literacy
Authors: Shangguan Lai , Chen Shu , Cao Lei
Published: March 2022

Under the background of healthy China, health education has been brought into the national education system. To improve the health literacy level of PE normal students in primary schools, this study studies the health literacy status of PE normal students in the “six-year junior middle school starting point system” using the methods of literature review, questionnaire survey, mathematical statistics, and so on. The results show that the health literacy level of “six-year junior high school starting point” PE normal students is close to that of national college students, but the health literacy is overall low. The success rate of health literacy of six-year physical education normal students from high to low is health skills, health knowledge, healthy lifestyle, and behavior; six-year physical education normal students have a high level of health skills, but a low level of healthy lifestyle and behavior. Countermeasures are put forward: optimizing the curriculum structure and strengthening health education; paying attention to health literacy and improving learning awareness; cultivating health awareness; maintaining the law of life, etc.
In Vitro and In Vivo Wound Healing Activity of Astragalus floccosus Boiss. (Fabaceae)
Authors: Akbari Fatemeh , Azadbakht Mohammad , Bagheri Ali , Vahedi Lale
Published: March 2022

Estrogens are a group of sex hormones which have receptors on the skin and lead to increased cells and wound healing. Normally isoflavonoids are present in Astragalus floccosus Boiss. (Leguminosae). Therefore, the present study was conducted to evaluate the presence of isoflavonoids in A. floccosus’ rich fraction of flavonoid and evaluate its wound healing effect accordingly. Flavonoids were evaluated by LCMS. Scratch was conducted and the medium culture was treated with the Astragalus’ rich fraction of flavonoid (RFF) and was compared with nontreated culture during 48 hours. In addition, in vivo full-thickness wound healing evaluation was performed on rats. The rats were put into four groups and treated on a daily basis for 21 days with a cream containing 1.5% of the RFF (group 1), silver sulfadiazine (group 2), and Vaseline (group 3) separately. The nontreated group (group 4) was created for a better comparison. During the examination, wound size was evaluated and histopathological examination was performed. Herbal analysis detected 11 flavonoids, including 2 isoflavonoids, Calycosin-7-O-beta-D-glucoside and Formononetin, in the RFF. In vitro scratch wound healing showed significant improvement with RFF treatment in comparison to nontreated medium. Furthermore, in vitro drug release of Astragalus ointment showed a stationary line during 24 h and 0.14 mg/ml of flavonoid penetrated the skin. In vivo wound size evaluation showed significant improvement in the group treated with the RFF in comparison to other groups. Histopathological results indicated that congestion, edema, inflammation, necrosis, and angiogenesis decreased during the examination and fibroblast proliferation fibrosis epithelization was increased especially in the RFF group in comparison to the silver sulfadiazine and free groups. In conclusion, A. floccosus showed that wound healing activity in both in vitro and in vivo analyses can be attributed to the presence of isoflavonoids with estrogen-like activity in this plant.
Rosuvastatin-Induced Oral Ulcer: A Case Report and Review of Literature
Authors: Algeffari Metab , Alsharidah Mansour
Published: March 2022

Background. The benefits of prescribing statins are well published in the treatment of hypercholesterolemia. With such widespread usage of statins, physicians may be ignoring or misdiagnosing the association of oral side effects with these medications. Case Summary. A 54-year-old man presented with a painful ulceration on the dorsum of his tongue that had been recurring for 10 months. Originally, he experienced a burning sensation on his tongue, and as the lesion advanced, the pain became more intense specially when consuming spicy or acidic foods. He is on rosuvastatin for the treatment of hypercholesterolemia for over five years. Several months prior to the lesion forming, his physician increased his daily dosage of rosuvastatin from 10 mg to 20 mg. Four weeks later at a follow-up appointment, all workup did not show any significant findings, the examination revealed a new ulcer on the dorsum of the tongue, and he reported no improvement after antifungal lozenges, nor when administered a short one-week treatment with oral steroids. After eight weeks of statin discontinued, the patient showed improvement with no episodes of ulceration. Conclusion. Physicians do note that statins affect multiple immunological pathways, which could explain some adverse cutaneous reactions. More research is needed in discovering the link of statins and oral disorders.
Diagnostic Value of Dynamic Enhanced Magnetic Resonance Imaging Combined with Serum CA15-3, CYFRA21-1, and TFF1 for Breast Cancer
Authors: Xue Feng , Meng Yu , Jiang Jie
Published: March 2022

Objective. To explore the diagnostic value of dynamic enhanced magnetic resonance imaging (MRI) combined with serum CA15-3, CYFRA21-1, and TFF1 for breast cancer. Methods. By means of a retrospective study, 60 breast cancer patients treated in our hospital from January 2018 to December 2020 were selected as the breast cancer group, 60 patients with benign breast lesions were selected as the benign group, and 60 healthy individuals who received physical examination in our hospital in the same period were selected as the control group. All study subjects received dynamic enhanced MRI scan and serological tests, their serum CA15-3 and CYFRA21-1 levels were measured with the electrochemiluminescence instrument and original auxiliary reagent, and the TFF1 level was measured with enzyme-linked immunosorbent assay (ELISA). The MRI performance variation in breast lesion patients was analyzed, the serum CA15-3, CYFRA21-1, and TFF1 levels of study subjects were compared among the three groups, and the efficacy of single diagnosis by dynamic enhanced MRI, CA15-3, CYFRA21-1, or TFF1 as well as combined diagnosis was explored by ROC curves. Results. Dynamic enhanced MRI showed that malignant lesion had obscure boundary, irregular margin, and heterogeneity after enhancement, and the time-signal intensity curve presented fast-in fast-out; the benign lesion had a clear boundary and smooth margin, 25 cases showed homogeneity after enhancement, and the time-signal intensity curve presented slow-in slow-out; the CA15-3, CYFRA21-1, and TFF1 levels were significantly different among the breast cancer group, benign group, and control group (33.81 ± 12.46 vs 19.02 ± 6.47 vs 9.55 ± 2.64, 4.08 ± 1.41 vs 1.96 ± 1.19 vs 0.99 ± 0.21, 1.39 ± 0.54 vs 1.04 ± 0.26 vs 0.89 ± 0.12,

P

 < 0.05); 57 breast cancer patients were diagnosed by a combined examination, with a sensitivity of 95.0%, specificity of 83.3%, positive predictive value of 74.0%, negative predictive value of 97.1%, accuracy rate of 87.2%, and AUC (95%CI) = 0.892 (0.840–0.943), indicating a significantly higher diagnostic value of the combined examination than the single examination by CA15-3, CYFRA21-1, TFF1, or MRI. Conclusion. Combining dynamic enhanced MRI with serum CA15-3, CYFRA21-1, and TFF1 has good efficacy in diagnosing breast cancer, which can be applied in clinical diagnosis of breast cancer.
Clinical Application of Perioperative Anaesthesia Management Based on Enhanced Recovery after Surgery Concept to Elderly Patients Undergoing Total Knee Replacement
Authors: Zhang Jizheng , Che Jinli , Sun Xiaohua , Ren Wanlu
Published: March 2022

Objective. To explore the clinical application effect of perioperative anesthesia management based on enhanced recovery after surgery (ERAS) concept to elderly patients undergoing total knee replacement (TKR). Methods. By means of retrospective analysis, the medical data of elderly patients undergoing TKR treated in our hospital (02, 2019–02, 2020) were analyzed, and 100 patients were selected as the study objects according to the inclusion and exclusion criteria and divided into the study group (SG) and reference group (RG) according to their admission order, with 50 cases each. Patients in SG received perioperative anesthesia management based on ERAS concept, and those in RG accepted routine perioperative anesthesia management, so as to compare the perioperative inflammatory factors levels, postoperative recovery indicators, and postoperative Numeric Rating Scale (NRS) scores between the two groups. Results. Compared with RG after surgery, SG obtained significantly lower inflammatory factors levels

P
<
0.001

and significantly better recovery indicators

P
<
0.05

, and the pain scores at postoperative 12 h and 24 h of SG were, respectively (1.46 ± 0.67) points and (2.00 ± 0.45) points, which were significantly lower than those of RG

P
<
0.05

. Conclusion. Perioperative anesthesia management based on EARS concept can improve the perioperative indicators of elderly patients undergoing TKR, result in less postoperative pain, and obtain a more desirable recovery.
Infarction Patterns and Recurrent Adverse Cerebrovascular Events in Moyamoya Disease
Authors: Yu Shao-Chen , Yin Zi-Han , Zeng Chao-Fan , Lin Fa , Ma Long , Zhang Yan , Zhang Dong , Zhao Ji-Zong
Published: March 2022

For moyamoya disease (MMD) patients who suffered an acute ischemic attack, the infarction patterns on DWI and its association with recurrent adverse cerebrovascular events (ACEs) after bypass surgery remain unknown. 327 patients who suffered an acute ischemic attack and received following revascularization surgery were retrospectively reviewed and were divided into three patterns according to the lesion number and distribution on DWI that obtained within 7 days of onset: no acute infarction (NAI), single acute infarction (SAI), and multiple acute infarctions (MAIs). We used Cox proportional hazard models to estimate hazard ratios (HR) for associations of infarction patterns and the risk of recurrent ACEs and strokes. Over a median follow-up of 41 months (IQR 26-60), there were 61 ACEs and 27 strokes. Compared to the NAI cohort, patients with SAI (HR, 2.92; 95% CI, 1.41-6.05;

p
=
0.004

) and MAIs (HR, 4.44; 95% CI, 2.10-9.41;

p
<
0.001

) were associated with higher risk of ACEs recurrences. In analysis adjusted for age and surgery modalities, the corresponding HR was 2.90 (95% CI: 1.41-5.98) for SAI and 4.10 (95% CI: 1.95-8.63) for MAIs, and this effect remained persistent on further adjustment for several potential confounders. Similar but less precise association was found in separate analysis that only takes into account stroke recurrences. Thus, different infarction patterns on DWI imply different risks of recurrent ACEs, and more attention should be paid to prevent ACEs in MMD patients with MAIs.
Audit as You Go: A Smart Contract-Based Outsourced Data Integrity Auditing Scheme for Multiauditor Scenarios with One Person, One Vote
Authors: Li Tengfei , Hu Liang
Published: March 2022

The data outsourcing services provided by cloud storage have greatly reduced the headache of data management for users, but the issue of remote data integrity poses further security concerns and computing burdens. The introduction of a third-party auditor (TPA) frees data owners from the auditing burden and alleviates disputes over the audit results between data owners and cloud storage providers. However, malicious cloud servers may collude with TPAs to deceive users for financial profits. Hiring multiple auditors in a single audit assignment appears to be a method to address the above problem, but the ensuing voting issues need to be further explored. In this paper, we proposed a smart contract-based outsourced data integrity auditing scheme for multiauditor scenarios. Unlike some existing schemes using reputation like factors as their voting weights, auditors in our scheme vote equally and audit as they go, without any maintenance. This mechanism not only frees auditors from trivia not related to the auditing but also avoids the drawbacks of centralization associated with over-high voting weights. The challenge used to check the integrity of the outsourced data is jointly generated by each involved auditor. Any collusion would be detected as long as there exists more than one honest auditor in the audit. We implement and deploy the scheme as Ethereum smart contracts. With the help of blockchain, the entire auditing process is public and transparent. Both the generated data and the obtained results are persisted with immutability, which ensures the traceability of all historical audits. The comprehensive theoretical and experimental analyses demonstrate that our scheme meets the claimed targets with high efficiency and low gas costs.