bluuebunny/crossref_metadata_2025 huggingface dataset:
Rehabilitation Prognostic Factors following Hip Fractures Associated with Patient’s Pre-Fracture Mobility and Functional Ability: A Prospective Observation Study
Authors: Koudouna Smaragda , Evangelopoulos Dimitrios S. , Sarantis Michail , Chronopoulos Efstathios , Dontas Ismene A. , Pneumaticos Spiridon
Published: August 2023

Low physical function is associated with poor outcomes in the elderly population suffering from hip fractures. The present study aims to evaluate the prognostic tools for predicting patient recovery after hip fractures and investigate the correlation between the pre-fracture motor and functional statuses. A prospective study was performed, including 80 patients suffering from hip fractures. Patient history, previous falls, the type of fracture and overall survival were evaluated. Patient-reported outcome measures (SF-36, EQ-5D/VAS, Charlson Comorbidity Index (CCI), Short Physical Performance Battery (SPPB), Timed Up and Go (TUG) and Harris Hip Score (HHS)) were monitored before hospital discharge at 6 weeks, and 3, 6 and 12 months postoperatively. Overall, 55% of patients experienced at least one fall, and 46% of them used crutches before the fracture. The average CCI score was 6.9. The SPPB score improved from 1.4 ± 1.3 (1 week) to 4.4 ± 2.1 (48 weeks). A one-year age increase, female sex, and prior history of falls lead to 0.1-, 0.92-, 0.56-fold lower SPPB scores, respectively, at 12 months. The HHS recorded the greatest improvement between 6 and 12 weeks (52.1 ± 14.6), whereas the TUG score continued to improve significantly from 139.1 ± 52.6 s (6 weeks) to 66.4 ± 54 s (48 weeks). The SPPB and performance test can be routinely used as a prognostic tool.
Analyzing the Fretting Fatigue of Bolt Joints by Experiments and Finite Element Analysis
Authors: Szlosarek Robert , Holzmüller Paul , Kröger Matthias
Published: August 2023

The appearance of fretting fatigue cracks in bolted sheets limits their lifetime. Furthermore, repairing these failures requires much effort due to needing to replace the components instead of replacing just the bolt. To prevent such failures, the purpose of this study is to understand the failure mechanism and to identify the major influencing parameters. Therefore, a representative joint of a bolt of size M22 and sheet material were investigated by experiments and a finite element analysis. The experiments were conducted over a wide range of preloads from zero to maximum preload. It turned out that the failure mode changes at 50 kN. For this preload, the influence of the surface and the use of a lubricant was observed. A grinded surface as well as the use of lubricant showed a change in the failure mode. The accompanying simulation showed that an analysis of the stresses delivers no proper explanation for the observed effects in the experiment. Therefore, the contact status was analyzed for various preloads and friction coefficients. The results correlate with the change in the failure mode. The conclusion is that both the stress state and the tribological behavior influence the failure mode and have to be considered in a numerical analysis.
Mass GGBFS Concrete Mixed with Recycled Aggregates as Alkali-Active Substances: Workability, Temperature History and Strength
Authors: Huo Yanlin , Huang Jinguang , Han Xiaoyu , Sun Huayang , Liu Tianan , Zhou Jingya , Yang Yingzi
Published: August 2023

This study provides the results of an experiment on the possibility of using high-volume ground granulated blast furnace slag (HVGGBFS)-based concrete as mass concrete. In addition to the control concrete, the total weight of the binder was 75% ground granulated blast furnace slag (GGBFS) and 25% ordinary Portland cement (OPC). For the aggregates, both natural and recycled aggregates were used. Three specimens with dimensions of 800 mm × 800 mm × 800 mm were prepared to simulate mass concrete. The workability, temperature aging and strength of the mass concrete were tested. The test results showed that utilizing HVGGBFS concrete as mass concrete can significantly reduce the heat of hydration due to the low heat of hydration of GGBFS, while the heat of hydration of GGBFS and recycled aggregate combination is 11.2% higher than normal concrete, with a slump that is 31.3% lower than that of plain concrete. The results also showed that the use of recycled aggregates in HVGGBFS concrete can significantly reduce workability. However, the compressive strength is higher than when natural aggregates are used due to the alkali activation effect caused by the recycled aggregates. The compressive strength at 7 and 28 days increased by 33.7% and 16.3%, respectively.
Computational Fracture Evolution Analysis of Steel-Fiber-Reinforced Concrete Using Concrete Continuous Damage and Fiber Progressive Models
Authors: Pokorska Iwona , Poński Mariusz , Kubissa Wojciech , Libura Tomasz , Brodecki Adam , Kowalewski Zbigniew
Published: August 2023

The process of concrete cracking is a common problem because the first micro-cracks due to the loss of moisture may appear even before the concrete is loaded. The application of fracture mechanics allows for a better understanding of this problem. Steel-fiber-reinforced concrete (SFRC) samples with a notch were subjected to a three-point bending test, and the results for crack energy were used to analyze the concrete’s material properties. In this paper, an experimental and numerical analysis of SFRC with rapid changes in the force (F) crack mouth opening displacement (CMOD) curve (F-CMOD) is presented. In order to obtain the relevant F-CMOD diagrams, three-point bending tests were carried out with non-standard samples with a thickness equal to one-third of the width of standard samples. For analysis purposes, crimped steel fibers were adopted. A probabilistic analysis of the most important parameters describing the material in question, such as peak strength, post-cracking strength, crack mouth opening displacement (CMOD), fracture energy, and the post-cracking deformation modulus, was conducted. The tests and the analysis of their results show that the quasi-static numerical method can be applied to obtain suitable results. However, significant dynamic effects during experiments that influence the F-CMOD curves are hard to reflect well in numerical calculations.
Three-Dimensional Peri-Implant Tissue Changes in Immediately vs. Early Placed Tapered Implants Restored with Two Different Ceramic Materials—1 Year Results
Authors: Strasding Malin , Jeong Yuwon , Marchand Laurent , Hicklin Stefan P. , Sailer Irena , Sun Minji , Lee Hyeonjong
Published: August 2023

Background: A prospective multi-center randomized controlled clinical trial was performed to digitally analyze tissue volume changes in immediately and early placed implants with simultaneous bone augmentation restored with two different all-ceramic materials. Methods: A total of 60 patients received 60 bone-level tapered implants (BLT, Straumann AG) immediately (n = 30) or early placed, 8–10 weeks after tooth extraction, (n = 30). Implants were restored with all-ceramic single crowns fabricated out of zirconia (Lava Plus, 3M), or lithium disilicate (E.max CAD, Ivoclar Vivadent AG) bonded to titanium base abutments (Variobase for Cerec, Straumann AG). Impressions were taken at baseline (BL), 6 and 12 months, and STL data were used to define an area of interest (AOI) to analyze peri-implant volume changes and midfacial recessions. Results: For immediate placement, a mean volume loss of −5.56 mm3 (±5.83 mm3) was found at 6 months, and of −6.62 mm3 (±6.56 mm3) at 12 months. For early placement, a mean volume loss of −1.99 mm3 (±5.82 mm3) at 6 months, and of −3.7 mm3 (±5.62 mm3) at 12 months was found. The differences in volume loss at 12 months between the two implant placement protocols were significant (p = 0.005). In both groups, mean midfacial recessions of 0.48 mm (±0.52) occurred. Conclusions: A more pronounced peri-implant volume loss can be expected 12 months after immediate implant placement compared with early placement.
Al2O3 Layers Grown by Atomic Layer Deposition as Gate Insulator in 3C-SiC MOS Devices
Authors: Schilirò Emanuela , Fiorenza Patrick , Lo Nigro Raffaella , Galizia Bruno , Greco Giuseppe , Di Franco Salvatore , Bongiorno Corrado , La Via Francesco , Giannazzo Filippo , Roccaforte Fabrizio
Published: August 2023

Metal-oxide-semiconductor (MOS) capacitors with Al2O3 as a gate insulator are fabricated on cubic silicon carbide (3C-SiC). Al2O3 is deposited both by thermal and plasma-enhanced Atomic Layer Deposition (ALD) on a thermally grown 5 nm SiO2 interlayer to improve the ALD nucleation and guarantee a better band offset with the SiC. The deposited Al2O3/SiO2 stacks show lower negative shifts of the flat band voltage VFB (in the range of about −3 V) compared with the conventional single SiO2 layer (in the range of −9 V). This lower negative shift is due to the combined effect of the Al2O3 higher permittivity (ε = 8) and to the reduced amount of carbon defects generated during the short thermal oxidation process for the thin SiO2. Moreover, the comparison between thermal and plasma-enhanced ALD suggests that this latter approach produces Al2O3 layers possessing better insulating behavior in terms of distribution of the leakage current breakdown. In fact, despite both possessing a breakdown voltage of 26 V, the T-ALD Al2O3 sample is characterised by a higher current density starting from 15 V. This can be attributable to the slightly inferior quality (in terms of density and defects) of Al2O3 obtained by the thermal approach and, which also explains its non-uniform dC/dV distribution arising by SCM maps.
Multi-Corpus Learning for Audio–Visual Emotions and Sentiment Recognition
Authors: Ryumina Elena , Markitantov Maxim , Karpov Alexey
Published: August 2023

Recognition of emotions and sentiment (affective states) from human audio–visual information is widely used in healthcare, education, entertainment, and other fields; therefore, it has become a highly active research area. The large variety of corpora with heterogeneous data available for the development of single-corpus approaches for recognition of affective states may lead to approaches trained on one corpus being less effective on another. In this article, we propose a multi-corpus learned audio–visual approach for emotion and sentiment recognition. It is based on the extraction of mid-level features at the segment level using two multi-corpus temporal models (a pretrained transformer with GRU layers for the audio modality and pre-trained 3D CNN with BiLSTM-Former for the video modality) and on predicting affective states using two single-corpus cross-modal gated self-attention fusion (CMGSAF) models. The proposed approach was tested on the RAMAS and CMU-MOSEI corpora. To date, our approach has outperformed state-of-the-art audio–visual approaches for emotion recognition by 18.2% (78.1% vs. 59.9%) for the CMU-MOSEI corpus in terms of the Weighted Accuracy and by 0.7% (82.8% vs. 82.1%) for the RAMAS corpus in terms of the Unweighted Average Recall.
Fuzzy Metrics in Terms of Fuzzy Relations
Authors: Grigorenko Olga , Šostak Alexander
Published: August 2023

In this paper, we study the concept of fuzzy metrics from the perspective of fuzzy relations. Specifically, we analyze the commonly used definitions of fuzzy metrics. We begin by noting that crisp metrics can be uniquely characterized by linear order relations. Further, we explore the criteria that crisp relations must satisfy in order to determine a crisp metric. Subsequently, we extend these conditions to obtain a fuzzy metric and investigate the additional axioms involved. Additionally, we introduce the definition of an extensional fuzzy metric or E-d-metric, which is a fuzzification of the expression d(x,y)=t. Thus, we examine fuzzy metrics from both the linear order and from the equivalence relation perspectives, where one argument is a value d(x,y) and the other is a number within the range [0,+∞).
Peakons and Persistence Properties of Solution for the Interacting System of Popowicz
Authors: Li Yaohong , Qin Chunyan
Published: August 2023

This paper focuses on a two-component interacting system introduced by Popowicz, which has the coupling form of the Camassa–Holm and Degasperis–Procesi equations. Using distribution theory, single peakon solutions and several double peakon solutions of the system are described in an explicit expression. Moreover, dynamic behaviors of several types of double peakon solutions are illustrated through figures. In addition, the persistence properties of the solutions to the Popowicz system in weighted Lp spaces is considered via a large class of moderate weights.
Proteomic and Transcriptomic Analyses to Decipher the Chitinolytic Response of Jeongeupia spp.
Authors: Arnold Nathanael D. , Garbe Daniel , Brück Thomas B.
Published: August 2023

In nature, chitin, the most abundant marine biopolymer, does not accumulate due to the action of chitinolytic organisms, whose saccharification systems provide instructional blueprints for effective chitin conversion. Therefore, discovery and deconstruction of chitinolytic machineries and associated enzyme systems are essential for the advancement of biotechnological chitin valorization. Through combined investigation of the chitin-induced secretome with differential proteomic and transcriptomic analyses, a holistic system biology approach has been applied to unravel the chitin response mechanisms in the Gram-negative Jeongeupia wiesaeckerbachi. Hereby, the majority of the genome-encoded chitinolytic machinery, consisting of various glycoside hydrolases and a lytic polysaccharide monooxygenase, could be detected extracellularly. Intracellular proteomics revealed a distinct translation pattern with significant upregulation of glucosamine transport, metabolism, and chemotaxis-associated proteins. While the differential transcriptomic results suggested the overall recruitment of more genes during chitin metabolism compared to that of glucose, the detected protein-mRNA correlation was low. As one of the first studies of its kind, the involvement of over 350 unique enzymes and 570 unique genes in the catabolic chitin response of a Gram-negative bacterium could be identified through a three-way systems biology approach. Based on the cumulative data, a holistic model for the chitinolytic machinery of Jeongeupia spp. is proposed.
Cortical and Trabecular Bone Stress Assessment during Periodontal Breakdown–A Comparative Finite Element Analysis of Multiple Failure Criteria
Authors: Moga Radu Andrei , Olteanu Cristian Doru , Buru Stefan Marius , Botez Mircea Daniel , Delean Ada Gabriela
Published: August 2023

Background and Objectives: This numerical analysis investigated the biomechanical behavior of the mandibular bone as a structure subjected to 0.5 N of orthodontic force during periodontal breakdown. Additionally, the suitability of the five most used failure criteria (Von Mises (VM), Tresca (T), maximum principal (S1), minimum principal (S3), and hydrostatic pressure (HP)) for the study of bone was assessed, and a single criterion was identified for the study of teeth and the surrounding periodontium (by performing correlations with other FEA studies). Materials and Methods: The finite element analysis (FEA) employed 405 simulations over eighty-one mandibular models with variable levels of bone loss (0–8 mm) and five orthodontic movements (intrusion, extrusion, tipping, rotation, and translation). For the numerical analysis of bone, the ductile failure criteria are suitable (T and VM are adequate for the study of bone), with Tresca being more suited. S1, S3, and HP criteria, due to their distinctive design dedicated to brittle materials and liquids/gas, only occasionally correctly described the bone stress distribution. Results: Only T and VM displayed a coherent and correlated gradual stress increase pattern for all five movements and levels of the periodontal breakdown. The quantitative values provided by T and VM were the highest (for each movement and level of bone loss) among all five criteria. The MHP (maximum physiological hydrostatic pressure) was exceeded in all simulations since the mandibular bone is anatomically less vascularized, and the ischemic risks are reduced. Only T and VM displayed a correlated (both qualitative and quantitative) stress increase for all five movements. Both T and VM displayed rotation and translation, closely followed by tipping, as stressful movements, while intrusion and extrusion were less stressful for the mandibular bone. Conclusions: Based on correlations with earlier numerical studies on the same models and boundary conditions, T seems better suited as a single unitary failure criterion for the study of teeth and the surrounding periodontium.
Review of the Case Reports on Metformin, Sulfonylurea, and Thiazolidinedione Therapies in Type 2 Diabetes Mellitus Patients
Authors: Susilawati Elis , Levita Jutti , Susilawati Yasmiwar , Sumiwi Sri Adi
Published: August 2023

Type 2 diabetes mellitus (T2DM) is the world’s most common metabolic disease. The development of T2DM is mainly caused by a combination of two factors: the failure of insulin secretion by the pancreatic β-cells and the inability of insulin-sensitive tissues to respond to insulin (insulin resistance); therefore, the disease is indicated by a chronic increase in blood glucose. T2DM patients can be treated with mono- or combined therapy using oral antidiabetic drugs and insulin-replaced agents; however, the medication often leads to various discomforts, such as abdominal pain, diarrhea or constipation, nausea and vomiting, and hypersensitivity reactions. A biguanide drug, metformin, has been used as a first-line drug to reduce blood sugar levels. Sulfonylureas work by blocking the ATP-sensitive potassium channel, directly inducing the release of insulin from pancreatic β-cells and thus decreasing blood glucose concentrations. However, the risk of the failure of sulfonylurea as a monotherapy agent is greater than that of metformin or rosiglitazone (a thiazolidinedione drug). Sulfonylureas are used as the first-line drug of choice for DM patients who cannot tolerate metformin therapy. Other antidiabetic drugs, thiazolidinediones, work by activating the peroxisome proliferator-activated receptor gamma (PPARγ), decreasing the IR level, and increasing the response of β-cells towards the glucose level. However, thiazolidines may increase the risk of cardiovascular disease, weight gain, water retention, and edema. This review article aims to discuss case reports on the use of metformin, sulfonylureas, and thiazolidinediones in DM patients. The literature search was conducted on the PubMed database using the keywords ‘metformin OR sulfonylureas OR thiazolidinediones AND case reports’, filtered to ‘free full text’, ‘case reports’, and ‘10 years publication date’. In some patients, metformin may affect sleep quality and, in rare cases, leads to the occurrence of lactate acidosis; thus, patients taking this drug should be monitored for their kidney status, plasma pH, and plasma metformin level. Sulfonylureas and TZDs may cause a higher risk of hypoglycemia and weight gain or edema due to fluid retention. TZDs may be associated with risks of cardiovascular events in patients with concomitant T2DM and chronic obstructive pulmonary disease. Therefore, patients taking these drugs should be closely monitored for adverse effects.
State of the Art Membrane Science and Technology in the Iberian Peninsula 2021–2022
Authors: Casado-Coterillo Clara , Santos Diogo M. F. , Tomé Liliana C. , Velizarov Svetlozar , Coelhoso Isabel , Calvo José Ignacio
Published: August 2023

This Special Issue of the journal Membranes arises from the need to highlight the developments in the field of membrane research and membrane processes that have been emerging in recent years by researchers and research groups based in the Iberian Peninsula [...]
The Stray Grains from Fragments in the Rejoined Platforms of Ni-Based Single-Crystal Superalloy
Authors: Huo Miao , Chen Chuyue , Jian Hangyue , Yang Wenchao , Liu Lin
Published: August 2023

Nickel-based single crystal superalloy is the most important material for blade preparation. However, some solidification defects inevitably occur during the process of preparing single-crystal blades through directional solidification. In this study, in order to study the origin of misorientation defects during solidification, a model with rejoined platforms was designed according to the geometry of single-crystal guide vanes. Electron Back-Scattering Diffraction (EBSD) was used to quantify the orientation deviation of the dendrites and identify the solidification defects in the rejoined platforms. The results showed that stray grain defects appeared in the platforms and their misorientation changed gradually, not abruptly. Combined with the simulation results, it was proposed that the stray grains formed as the result of the dendrites fragment, which was induced by solute enrichment in the mushy zone during solidification. Meanwhile, it was accompanied by a obvious dendritic deformation, which was caused by solidification shrinkage stress. This suggested that the fragmentation was induced by multiple factors, among which, the concave interface shape provided favorable conditions for solute enrichment, and the dynamic variability in the local thermal gradient and fluctuations of the solidification rate might play catalytic roles.
Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines
Authors: Zhang Ying , Barupal Dinesh K. , Fan Sili , Gao Bei , Zhu Chao , Flenniken Ann M. , McKerlie Colin , Nutter Lauryl M. J. , Lloyd Kevin C. Kent , Fiehn Oliver
Published: August 2023

Although metabolic alterations are observed in many monogenic and complex genetic disorders, the impact of most mammalian genes on cellular metabolism remains unknown. Understanding the effect of mouse gene dysfunction on metabolism can inform the functions of their human orthologues. We investigated the effect of loss-of-function mutations in 30 unique gene knockout (KO) lines on plasma metabolites, including genes coding for structural proteins (11 of 30), metabolic pathway enzymes (12 of 30) and protein kinases (7 of 30). Steroids, bile acids, oxylipins, primary metabolites, biogenic amines and complex lipids were analyzed with dedicated mass spectrometry platforms, yielding 827 identified metabolites in male and female KO mice and wildtype (WT) controls. Twenty-two percent of 23,698 KO versus WT comparison tests showed significant genotype effects on plasma metabolites. Fifty-six percent of identified metabolites were significantly different between the sexes in WT mice. Many of these metabolites were also found to have sexually dimorphic changes in KO lines. We used plasma metabolites to complement phenotype information exemplified for Dhfr, Idh1, Mfap4, Nek2, Npc2, Phyh and Sra1. The association of plasma metabolites with IMPC phenotypes showed dramatic sexual dimorphism in wildtype mice. We demonstrate how to link metabolomics to genotypes and (disease) phenotypes. Sex must be considered as critical factor in the biological interpretation of gene functions.
Metabolomics Approaches for the Diagnosis, Treatment, and Better Disease Management of Viral Infections
Authors: Al-Sulaiti Haya , Almaliti Jehad , Naman C. Benjamin , Al Thani Asmaa A. , Yassine Hadi M.
Published: August 2023

Metabolomics is an analytical approach that involves profiling and comparing the metabolites present in biological samples. This scoping review article offers an overview of current metabolomics approaches and their utilization in evaluating metabolic changes in biological fluids that occur in response to viral infections. Here, we provide an overview of metabolomics methods including high-throughput analytical chemistry and multivariate data analysis to identify the specific metabolites associated with viral infections. This review also focuses on data interpretation and applications designed to improve our understanding of the pathogenesis of these viral diseases.
Metabolism Study of Anamorelin, a GHSR1a Receptor Agonist Potentially Misused in Sport, with Human Hepatocytes and LC-HRMS/MS
Authors: Gameli Prince Sellase , Taoussi Omayema , Basile Giuseppe , Carlier Jeremy , Busardò Francesco Paolo
Published: August 2023

Anamorelin, developed for the treatment of cancer cachexia, is an orally active medication that improves appetite and food intake, thereby increasing body mass and physical functioning. It is classified as a growth hormone secretagogue and strictly monitored by the World Anti-Doping Agency (WADA), owing to its anabolic enhancing potential. Identifying anamorelin and/or metabolite biomarkers of consumption is critical in doping controls. However, there are currently no data available on anamorelin human metabolic fate. The aim of this study was to investigate and identify biomarkers characteristic of anamorelin intake using in silico metabolite predictions with GLORYx, in vitro incubation with 10-donor-pooled human hepatocytes, liquid chromatography-high-resolution tandem mass spectrometry (LC-HRMS/MS) analysis, and data processing with Thermo Scientific’s Compound Discoverer. In silico prediction resulted in N-acetylation at the methylalanyl group as the main transformation (score, 88%). Others including hydroxylation at the indole substructure, and oxidation and N-demethylation at the trimethylhydrazino group were predicted (score, ≤36%). Hepatocyte incubations resulted in 14 phase I metabolites formed through N-demethylation at the trimethylhydrazino group, N-dealkylation at the piperidine ring, and oxidation at the indole and methylalanyl groups; and two phase II glucuronide conjugates occurring at the indole. We propose four metabolites detected as specific biomarkers for toxicological screening.
Metal-Induced Trap States: The Roles of Interface and Border Traps in HfO2/InGaAs
Authors: Do Huy-Binh , Luc Quang-Ho , Pham Phuong V. , Phan-Gia Anh-Vu , Nguyen Thanh-Son , Le Hoang-Minh , De Souza Maria Merlyne
Published: August 2023

By combining capacitance–voltage measurements, TCAD simulations, and X-ray photoelectron spectroscopy, the impact of the work function of the gate metals Ti, Mo, Pd, and Ni on the defects in bulk HfO2 and at the HfO2/InGaAs interfaces are studied. The oxidation at Ti/HfO2 is found to create the highest density of interface and border traps, while a stable interface at the Mo/HfO2 interface leads to the smallest density of traps in our sample. The extracted values of Dit of 1.27 × 1011 eV−1cm−2 for acceptor-like traps and 3.81 × 1011 eV−1cm−2 for donor-like traps are the lowest reported to date. The density and lifetimes of border traps in HfO2 are examined using the Heiman function and strongly affect the hysteresis of capacitance–voltage curves. The results help systematically guide the choice of gate metal for InGaAs.
Late Paleozoic Tectonic Evolution of the Northern Great Xing’an Range, Northeast China: Constraints from Carboniferous Magmatic Rocks in the Wunuer Area
Authors: Li Liyang , Zhang Chuanheng , Feng Zhiqiang
Published: August 2023

Northeast China composes the main part of the Central Asian Orogenic Belt. Traditionally, Northeast China has been considered a collage of several microcontinental blocks. However, the tectonic evolution of these blocks remains uncertain. Igneous rocks can be used to infer the magmatic histories of the blocks and thus help reconstruct their evolution. In this study, we present new zircon U–Pb and whole-rock geochemical data for Carboniferous igneous rocks from the Wunuer area, northern Great Xing’an Range, Northeast China, to constrain the Carboniferous amalgamation of the united Xing’an–Erguna and Songnen–Zhangguangcai Range massifs. On the basis of zircon U–Pb dating results, we identify two main stages of magmatism, i.e., early Carboniferous (332–329 Ma) and late Carboniferous (312–310 Ma). The early Carboniferous igneous rocks include diorites and granodiorites, with the former being classified as calc-alkaline to tholeiitic and the latter as tholeiitic. Both rock types are enriched in Th and U and depleted in Nb and Ti. The rocks display slightly fractionated rare earth element (REE) patterns, with an enrichment in light REEs and a depletion in heavy (H)REEs. The geochemical characteristics of the early Carboniferous rocks indicate that they formed in a subduction-related continental-arc setting. The late Carboniferous igneous rocks include monzogranites and syenogranites, both of which are classified as high-K calc-alkaline rocks and show enrichment in Th, U, and Rb and depletion in Nb and Ti. The rocks display strongly fractionated REE patterns, with an enrichment in light REEs and a depletion in HREEs. The geochemical characteristics of the late Carboniferous rocks indicate that they formed in a syn-collisional tectonic setting. Combining the new geochronological and geochemical results and inferred tectonic settings with regional magmatic data, we propose a new three-stage model to interpret the late Paleozoic tectonic evolution of the united Xing’an–Erguna and Songnen–Zhangguangcai Range massifs of Northeast China: (1) early Carboniferous (360–340 Ma) subduction of the Paleo-Asian oceanic plate beneath the united Xing’an–Erguna Massif and formation of the Wunuer oceanic basin in the Yakeshi area; (2) early to late Carboniferous (340–310 Ma) sustained subduction of the Paleo-Asian oceanic plate beneath the united Xing’an–Erguna Massif and initiation of subduction of the Wunuer oceanic basin; and (3) late Carboniferous–early Permian (310–275 Ma) syn-collisional to post-collisional tectonic transition between the united Xing’an–Erguna Massif and the Songnen–Zhangguangcai Range Massif.
The Mineral Chemistry of Magnetite and Its Constraints on Ore-Forming Mechanism in the Sandaozhuang Skarn-Type W-Mo Deposit in East Qinling, China
Authors: Zeng Zhijie , Siddique Uzair , Sun Miaojun , Gao Qin , Chen Yanting , Chen Lei , Li Zilong
Published: August 2023

The Sandaozhuang super-large W-Mo deposit is located in the southern margin of the North China Craton, within the well-known East Qinling Mo mineralization belt, and is one of the typical skarn-type W-Mo deposits in China. Based on EMPA and LA-ICP-MS analyses, major and trace elements were presented, and the mineral chemistry of magnetite at various mineralization stages was discussed. Combining field observations, petrography, and geochemical characteristics, the magnetite at the Sandaozhuang deposit can be classified into three types, namely early-magmatic-stage high-temperature magnetite (Mag1), potassic-alteration-stage magnetite (Mag2), and retrograde-alteration-stage magnetite (Mag3). The Mag1 and Mag2 magnetites primarily occurred in granites in association with potassium (K) feldspar and biotite, whereas Mag3 is associated with metallic sulfide minerals that occurred mainly in vein-like structures in skarn. The three magnetites Mag1, Mag2, and Mag3 can be distinguished as having magmatic, magmatic–hydrothermal transition, and hydrothermal origins, respectively. All three types of magnetite exhibit a depletion of high-field-strength elements (HFSEs) such as Zr, Hf, Nb, Ta, and Ti, and large-ion lithophile elements (LILEs) including Rb, K, Ba, and Sr, compared to the mean continental crust composition. Conversely, they are enriched in elements such as Sn, Mo, V, Cr, Zn, and Ga. Mag3 showed no significant depletion of Co, Ni, Cu, and Bi, indicating that the influence of coexisting sulfides on the composition of magnetite at the Sandaozhuang deposit is limited. There are systematic variations in major and trace elements from Mag1 to Mag3, which exhibited similar patterns in trace element spider and rare earth element diagrams, and Y/Ho ratio, indicating a consistent source for the three types of magnetite. The changes in V and Cr contents and (Ti + V) vs. (Al + Mn) diagram of magnetite at the Sandaozhuang deposit reflected the evolution of ore-forming fluids with an initial increase in oxygen fugacity and a subsequent decrease, as well as a gradual decrease in temperature during skarn mineralization. The early high-temperature and high-oxygen-fugacity magmatic fluids became W and Mo enriched by hydrothermal fluid interaction. The rapid change in fluid properties during the retrograde alteration stage led to the precipitation of scheelite and molybdenite.
Utilizing Remote Sensing and Satellite-Based Bouguer Gravity data to Predict Potential Sites of Hydrothermal Minerals and Gold Deposits in Central Saudi Arabia
Authors: El-Raouf Amr Abd , Doğru Fikret , Azab Islam , Jiang Lincheng , Abdelrahman Kamal , Fnais Mohammed S. , Amer Omar
Published: August 2023

This article aims to aid in exploring and forecasting hydrothermal minerals and gold deposits in Central Saudi Arabia (SA), with a focus on structural contexts. Remote sensing (RS) and satellite-based Bouguer gravity (SBG) data were integrated in order to create a mineral prediction map for the researched location. Data from the Landsat Operational Land Imager (OLI) and Shuttle Radar Topography Mission (SRTM) were transformed and enhanced using a variety of approaches. The delineation of hydrothermal alteration zones (HAZs) and highlighting of structural discontinuities in the OLI data were made possible using band ratios and oriented principal component analysis (PCA). Additionally, the underlying structural features were successfully exposed by processing the SBG using a variety of edge detection techniques, like the analytical signal (AS), total horizontal derivative (THD), tilt angle (TA), horizontal tilt angle (TDX), theta map (TM), horizontal derivative of the tilt derivative (HD_TDR), horizontal gradient of the tilt angle (HGTA), tilt angle of the analytical signal (TAAS), and soft sign function (SF). As a result, more prominent lineaments were found in the NW–SE, NNW–SSE, NE–SW, and NNE–SSW directions than in the N–S and E–W directions. The GIS incorporated surface/subsurface geological structure density maps with zones of hydrothermal alteration. It was found that the lineaments derived from the analysis of the RS and SBG data were more in line with the HAZs, which demonstrated the common connection between alteration zones and deep lineaments. The findings revealed a mineral prediction map with extremely low to extremely high probabilities. Overall, combining RS and SBG data effectively identified probable mineralization sites associated with hydrothermal processes and made it easier to create this study’s final predictive mineralization map.
Multiprotein Adsorption from Human Serum at Gold and Oxidized Iron Surfaces Studied by Atomic Force Microscopy and Polarization-Modulation Infrared Reflection Absorption Spectroscopy
Authors: Huang Jingyuan , Qiu Yunshu , Lücke Felix , Su Jiangling , Grundmeier Guido , Keller Adrian
Published: August 2023

Multiprotein adsorption from complex body fluids represents a highly important and complicated phenomenon in medicine. In this work, multiprotein adsorption from diluted human serum at gold and oxidized iron surfaces is investigated at different serum concentrations and pH values. Adsorption-induced changes in surface topography and the total amount of adsorbed proteins are quantified by atomic force microscopy (AFM) and polarization-modulation infrared reflection absorption spectroscopy (PM-IRRAS), respectively. For both surfaces, stronger protein adsorption is observed at pH 6 compared to pH 7 and pH 8. PM-IRRAS furthermore provides some qualitative insights into the pH-dependent alterations in the composition of the adsorbed multiprotein films. Changes in the amide II/amide I band area ratio and in particular side-chain IR absorption suggest that the increased adsorption at pH 6 is accompanied by a change in protein film composition. Presumably, this is mostly driven by the adsorption of human serum albumin, which at pH 6 adsorbs more readily and thereby replaces other proteins with lower surface affinities in the resulting multiprotein film.
Chemical Modification of Polysaccharides: A Review of Synthetic Approaches, Biological Activity and the Structure–Activity Relationship
Authors: Liu Tianbo , Ren Qianqian , Wang Shuang , Gao Jianing , Shen Congcong , Zhang Shengyu , Wang Yanhong , Guan Feng
Published: August 2023

Natural polysaccharides are macromolecular substances with great potential owing to their wide biological activity and low toxicity. However, not all polysaccharides have significant pharmacodynamic activity; hence, appropriate chemical modification methods can be selected according to the unique structural characteristics of polysaccharides to assist in enhancing and promoting the presentation of their biological activities. This review summarizes research progress on modified polysaccharides, including common chemical modification methods, the change in biological activity following modification, and the factors affecting the biological activity of chemically modified polysaccharides. At the same time, the difficulties and challenges associated with the structural modification of natural polysaccharides are also outlined in this review. Thus, research on polysaccharide structure modification is critical for improving the development and utilization of sugar products.
Corrosion Resistance in Artificial Perspiration of Cr-Based Decorative Coatings
Authors: Carneiro Edgar , Castro José David , Lima Maria José , Ferreira Jorge , Carvalho Sandra
Published: August 2023

We aim at developing hexavalent chromium-free coatings for frequently touched decorative parts. Cr(N,O) and multilayered CrN/CrO coatings were deposited by means of reactive magnetron sputtering. All samples presented good adhesion to the substrates enhanced by an epoxy layer designed to enhance PVD coating adhesion. Similar substrates are found in the automotive industry and can be used in appliances where a metallic finish is desired by the consumer. Corrosion behavior was induced, using artificial sweat to simulate long exposure to human touch for 96 h. In potentiodynamic polarization tests, the coatings were revealed to be nobler than the substrate alone. Cr displayed a non-existent passivation region, while gCrN exhibited a quick passivation of the surface and its respective breakdown and several current fluctuations, indicating the occurrence of pitting, which was confirmed by SEM micrography after the corrosion. Regarding EIS results, all films depicted a diminution of impedance modulus (|Z|) after 96 h, which indicates a diminution of corrosion resistance against artificial sweat. Nitride films exhibited the worst anticorrosive features. On the other hand, Cr and CrO exhibited the highest |Z| values. These results are corroborated by low the corrosion rates of both coatings. The equivalent electrical circuit allows us to confirm oxide formation in the outermost layer of the films due to electrolyte/surface interaction, indicating a self-protecting mechanism. Nitride films showed the lowest values and less corrosion resistance, confirming the results obtained in polarization potentiodynamic tests. The coatings developed in this work, namely Cr and CrO, showed a promising corrosion resistance behavior that could endure a lifetime of frequent human touch in various decorative applications either automotive or general appliances.
A Study of the Microstructure and Tribological Properties of Copper-Based Cr@graphite Alloy Modified by Nano Cr3C2 and CrC
Authors: Wang Yiran , Gao Yimin , Li Yefei
Published: August 2023

Railway switch plates are important components in railroads, and copper-based graphite alloys have potential as substitutes for traditional materials. Graphite as an anti-friction phase could decrease both the friction coefficient and mechanical properties, with an increasing mass fraction for their poor interface bonding strength. Chromium, a multifunctional metal plated on the graphite (Cr@graphite), has solved this problem. Results have shown that a copper-based Cr@graphite alloy is composed of copper as a base, and graphite and Cr compound transition phase as reinforcements. The transition phase is made up of nano Cr3C2 and dispersed CrC, which offers a stable combination with both graphite and copper. The tribological property of copper-based graphite alloy exhibits a steadily decreasing slope with reinforcement content increasing, and the Cr@graphite samples show lower values than the alloy without any coating treatment. Both graphite and chromic oxide play role in antifriction, and are more efficient than graphite alone. Microcutting is the dominant wear method when copper-based Cr@graphite alloy has a 1~4 wt.% reinforcements content; additionally, adhesion wear and oxidation are also generated. When the anti-friction phase increases, the wear mechanism is affected, and fatigue deformation is the dominant wear method at 4~6 wt.% content. The formation of the chromic oxide phase, as well as the graphite phase, control the formation of an anti-friction layer. In that case, the tribological properties are dramatically improved with reinforcement content enhance.
Coupling Effects of Cross-Corticomuscular Association during Object Manipulation Tasks on Different Haptic Sensations
Authors: Guerrero-Mendez Cristian D. , Blanco-Diaz Cristian F. , Rivera-Flor Hamilton , De Souza Alberto F. , Jaramillo-Isaza Sebastian , Ruiz-Olaya Andres F. , Bastos-Filho Teodiano F.
Published: August 2023

The effects of corticomuscular connectivity during object manipulation tasks with different haptic sensations have not been quantitatively investigated. Connectivity analyses enable the study of cortical effects and muscle responses during movements, revealing communication pathways between the brain and muscles. This study aims to examine the corticomuscular connectivity of three Electroencephalography (EEG) channels and five muscles during object manipulation tasks involving contact surfaces of Sandpaper, Suede, and Silk. The analyses included 12 healthy subjects performing tasks with their right hand. Power-Based Connectivity (PBC) and Mutual Information (MI) measures were utilized to evaluate significant differences in connectivity between contact surfaces, EEG channels, muscles, and frequency bands. The research yielded the following findings: Suede contact surface exhibited higher connectivity; Mu and Gamma frequency bands exerted greater influence; significant connectivity was observed between the three EEG channels (C3, Cz, C4) and the Anterior Deltoid (AD) and Brachioradialis (B) muscles; and connectivity was primarily involved during active movement in the AD muscle compared to the resting state. These findings suggest potential implementation in motor rehabilitation for more complex movements using novel alternative training systems with high effectiveness.
Low-Calorie Ketogenic Diet: Potential Application in the Treatment of Polycystic Ovary Syndrome in Adolescents
Authors: Calcaterra Valeria , Cena Hellas , Sottotetti Francesca , Hruby Chiara , Madini Nagaia , Zelaschi Noemi , Zuccotti Gianvincenzo
Published: August 2023

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Hyperandrogenism, hyperinsulinism and insulin resistance (IR) are the main drivers of clinical, metabolic and reproductive phenotypes of PCOS. In adolescence, the cornerstones of PCOS treatment are lifestyle and dietary interventions. In particular, the quality and quantity of carbohydrates introduced with the diet play a crucial role in the benefits of diet on PCOS. Recently, the ketogenic diet (KD) has attracted significant interest for the treatment of IR and for the control of carbohydrate metabolism, which has proven to be beneficial for several dysmetabolic conditions, including PCOS. The goal of the KD is to induce a fasting-like metabolism with production of chetonic bodies. Ketosis is a good regulator of calorie intake and mimics the starvation effect in the body, leading to body weight control and consequent metabolism. Additionally, during ketogenesis, insulin receptor sensitivity is also promoted. We proposed a broad overview of the available literature regarding KD indications and considered its metabolic benefits useful for improving PCOS management. The reported data support that a low-calorie ketogenic diet (LCKD) plays a positive role as a regulator of control weight, IR, glucose and lipid homeostasis and hormonal profile. Unfortunately, the evidence concerning the benefits of the very LCKD in adolescents with PCOS and excessive body weight is still numerically scarce. Further studies are necessary to understand whether these effects are due to weight loss or to the nutritional characteristics of this diet. Considering the long-term consequences of PCOS, it is crucial to detect the prospects of nutritional interventions to protect fertility, starting in adolescence.
Functional Food in Relation to Gastroesophageal Reflux Disease (GERD)
Authors: Herdiana Yedi
Published: August 2023

Gastroesophageal reflux disease (GERD) is a common esophageal disorder characterized by troublesome symptoms associated with increased esophageal acid exposure. The cornerstones of therapy in this regard include treatment with acid-suppressive agents, lifestyle modifications, and dietary therapy, although the latter has not been well defined. As concerns regarding long-term proton pump inhibitor (PPI) use continue to be explored, patients and healthcare providers are becoming increasingly interested in the role of diet in disease management. However, dietary interventions lack evidence of the synthesis effect of functional foods. The following is a review of dietary therapy for GERD, emphasizing food components’ impact on GERD pathophysiology and management. Although the sequential dietary elimination of food groups is a common practice, the literature supports broader intervention, including reduced overall sugar intake, increased dietary fiber, and changes in overall eating practices. While the primary concern of food companies is to provide safe products, the caloric, nutritional, and functional composition of foods is also generating interest in the food industry due to consumers’ concerns.
Effects of Quinine on the Glycaemic Response to, and Gastric Emptying of, a Mixed-Nutrient Drink in Females and Males
Authors: Rezaie Peyman , Bitarafan Vida , Rose Braden David , Lange Kylie , Mohammadpour Zinat , Rehfeld Jens Frederik , Horowitz Michael , Feinle-Bisset Christine
Published: August 2023

Intraduodenal quinine, in the dose of 600 mg, stimulates glucagon-like peptide-1 (GLP-1), cholecystokinin and insulin; slows gastric emptying (GE); and lowers post-meal glucose in men. Oral sensitivity to bitter substances may be greater in women than men. We, accordingly, evaluated the dose-related effects of quinine on GE, and the glycaemic responses to, a mixed-nutrient drink in females, and compared the effects of the higher dose with those in males. A total of 13 female and 13 male healthy volunteers received quinine-hydrochloride (600 mg (‘QHCl-600’) or 300 mg (‘QHCl-300’, females only) or control (‘C’), intraduodenally (10 mL bolus) 30 min before a drink (500 kcal, 74 g carbohydrates). Plasma glucose, insulin, C-peptide, GLP-1, glucose-dependent insulinotropic polypeptide (GIP) and cholecystokinin were measured at baseline, for 30 min after quinine alone, and then for 2 h post-drink. GE was measured by 13C-acetate breath-test. QHCl-600 alone stimulated insulin, C-peptide and GLP-1 secretion compared to C. Post-drink, QHCl-600 reduced plasma glucose, stimulated C-peptide and GLP-1, and increased the C-peptide/glucose ratio and oral disposition index, while cholecystokinin and GIP were less, in females and males. QHCl-600 also slowed GE compared to C in males and compared to QHCl-300 in females (p < 0.05). QHCl-300 reduced post-meal glucose concentrations and increased the C-peptide/glucose ratio, compared to C (p < 0.05). Magnitudes of glucose lowering and increase in C-peptide/glucose ratio by QHCl-600 were greater in females than males (p < 0.05). We conclude that quinine modulates glucoregulatory functions, associated with glucose lowering in healthy males and females. However, glucose lowering appears to be greater in females than males, without apparent differential effects on GI functions.