bluuebunny/crossref_metadata_2025 huggingface dataset:
Threat and Enhancement
Authors: Lynch Teresa , Erxleben Matthew R. , Perreault Gregory P.
Published: May 2023

Abstract: Advancing hypotheses derived from social identity theory, we investigated the influence of gamer identity affiliation on affective responses to identity threats and enhancements. Participants viewed a message that either devalued (i.e., threatened) or elevated (i.e., enhanced) the status of gamers when associating them with a mass shooting event. Relative to a control condition that neither threatened nor enhanced identity, our data demonstrated that gamer identity affiliation moderated affect. Specifically, greater gamer affiliation increased negative affect experienced after a threatening message. By contrast, greater gamer affiliation increased positive affect and reduced negative affect experienced after an enhancement message. Analyses of participants’ emotional reactions to the messages revealed that individuals with stronger gamer identity affiliation reported relatively more homogeneous emotions relative to individuals less affiliated with gamer identity. We discuss these response patterns with respect to how emotions may shape intergroup interaction in online communication.
Early Evolution of the Stratospheric Aerosol Plume Following the 2022 Hunga Tonga‐Hunga Ha'apai Eruption: Lidar Observations From Reunion (21°S, 55°E)
Authors: Baron A. , Chazette P. , Khaykin S. , Payen G. , Marquestaut N. , Bègue N. , Duflot V.
Published: May 2023

The exceptionally violent eruption of the Hunga Tonga‐Hunga Ha'apai volcano (HTHH) of 15 January 2022, in the South Pacific, was associated with a powerful blast that injected gases, steam and aerosol to unprecedentedly high altitudes. This article details unique observations of the young volcanic plume from ground‐based lidars at Reunion (21°S, 55°E). Two lidars, operating at wavelengths of 355 and 532 nm, recorded the plume overhead from 19 January until 28 January providing the vertical structure and the optical properties of the plume. A series of thick stratospheric plumes between 36 and 18 km altitude have been characterized along time, with aerosol optical depth as high as 0.84 at 532 nm and negative Angström exponents for the main layers down to −0.8 ± 0.8. The diversity of plumes properties is explained by the injection heights of the volcanic material as well as stratospheric dynamics and chemistry.
Sensitivities of the Asian Summer Monsoon Simulations to Physical Parameters for the Perturbed Parameter Ensemble of HadGEM3‐GC3.05
Authors: Zhang Xiaoqi , He Bian , Guo Zhun , Sexton David M. H. , Rostron John W. , Furtado Kalli
Published: May 2023

The simulation skill of the perturbed parameter ensemble (PPE) of HadGEM3‐GC3.05 on the mean climate pattern of the Asian summer monsoon (ASM) is evaluated in this study. The sensitivities of the model bias to the perturbed parameters are investigated based on metrics. The results show that the PPE mean (PPE‐20M) could effectively capture the general ASM precipitation and wind patterns, with a correlation coefficient of 0.78. PPE‐20M mainly shows positive precipitation biases over the tropical western Pacific, southern slope of the Tibetan Plateau, Indochina Peninsula, and South China and negative precipitation biases over the Indian continent and Bay of Bengal. The magnitude of the precipitation biases is more sensitive than its pattern to the variation of the perturbed parameters. Four parameters (ent_fac_dp, qlmin, ps_cloud‐ph, and psm) are found to be crucial for simulating the ASM precipitation intensity, and their combined effects are related to the simulated precipitation biases.
On the Energy‐Dependent Deep (L < 3.5) Penetration of Radiation Belt Electrons
Authors: Mei Yang , Li Xinlin , Zhao Hong , Sarris Theodore , Khoo Lengying , Hogan Benjamin , O’Brien Declan , Califf Sam
Published: May 2023

Deep penetration of outer radiation belt electrons to low L (<3.5) has long been recognized as an energy‐dependent phenomenon but with limited understanding. The Van Allen Probes measurements have clearly shown energy‐dependent electron penetration during geomagnetically active times, with lower energy electrons penetrating to lower L. This study aims to improve our ability to model this phenomenon by quantitatively considering radial transport due to large‐scale azimuthal electric fields (E‐fields) as an energy‐dependent convection term added to a radial diffusion Fokker‐Planck equation. We use a modified Volland‐Stern model to represent the enhanced convection field at lower L to match the observations of storm time values of E‐field. We model 10–400 MeV/G electron phase space density with an energy‐dependent radial diffusion coefficient and this convection term and show that the model reproduces the observed deep penetrations well, suggesting that time‐variant azimuthal E‐fields contribute preferentially to the deep penetration of lower‐energy electrons.
Rapid Development of Systematic ENSO‐Related Seasonal Forecast Errors
Authors: Beverley J. D. , Newman M. , Hoell A.
Published: May 2023

Climate models exhibit known systematic errors in their representation of the El Niño‐Southern Oscillation (ENSO). In this study, we show that such simulation errors are largely present in tropical seasonal prediction, even for short lead times. Regressing monthly forecast errors from 11 different operational models upon the observed ENSO state, we find that predicted ENSO‐related sea surface temperature anomalies (of either sign) for winter/spring are significantly extended or shifted to the west and are also too persistent during the ENSO decay phase, both common climate model errors. There are also corresponding precipitation forecast errors, most notably a robust westward shift of the ENSO‐related precipitation dipole that may impact predictions of extratropical teleconnections. These ENSO‐related errors develop within days after initialization regardless of month, including significant errors appearing in anomalous surface trade winds, and saturate so rapidly that they primarily depend upon the seasonal cycle rather than lead time.
A Global Assessment of the Controls on the Fractionation of Arc Magmas
Authors: Klein Benjamin Z. , Jagoutz Oliver , Schmidt Max W. , Kueter Nico
Published: May 2023

During the differentiation of arc magmas, fractionating liquids follow a series of cotectics, where the co‐crystallization of multiple minerals control the melt compositional trajectories, commonly referred to as liquid lines of descent (LLD). These cotectics are sensitive to intensive properties, including fractionation pressure and melt H2O concentration, and changes in these variables produce systematic differences in the LLDs of arc lavas. Based on a compilation of experimental studies, we develop two major element proxies that exploit differences in LLDs to constrain the fractionation conditions of arc magmas. Near‐primary fractionating magmas evolve along the olivine‐clinopyroxene cotectic, which is pressure‐sensitive. We use this sensitivity to develop a proxy for early fractionation pressure based on the normative mineral compositions of melts with 8 ± 1 wt.% MgO. Fractionation in more evolved magmas is controlled by the clinopyroxene‐plagioclase cotectic, which is strongly sensitive to magmatic H2O contents. We use this relationship to develop an H2O proxy that is calibrated to the normative mineral components of melts with 2–4 wt.% MgO. These two proxies provide new tools for estimating the variations in pressure and temperature between magmatic systems. We applied these proxies to compiled major element data and phenocryst assemblages from modern volcanic arcs and show that in island arcs early fractionation is relatively shallow and magmas are dominantly H2O‐poor, while continental arcs are characterized by more hydrous and deeper early fractionation. These differences likely reflect variations in the relative contributions of decompression and flux melting in combination with distinct upper plate controls on arc melt generation.
Identifying the Deep‐Inflow Mixing Features in Orographically‐Locked Diurnal Convection
Authors: Chang Yu‐Hung , Chen Wei‐Ting , Wu Chien‐Ming , Kuo Yi‐Hung , Neelin J. David
Published: May 2023

Orographically‐locked diurnal convection involves interactions between local circulation and the thermodynamic environment of convection. Here, the relationships of convective updraft structures over orographic precipitation hotspots and their upstream environment in the TaiwanVVM large‐eddy simulations are analyzed for the occurrence of the orographic locking features. Strong convective updraft columns within heavily precipitating, organized systems exhibit a mass flux profile gradually increasing with height through a deep lower‐tropospheric inflow layer. Enhanced convective development is associated with higher upstream moist static energy (MSE) transport through this deep‐inflow layer via local circulation, augmenting the rain rate by 36% in precipitation hotspots. The simulations provide practical guidance for targeted observations within the most common deep‐inflow path. Preliminary field measurements support the presence of high MSE transport within the deep‐inflow layer when organized convection occurs at the hotspot. Orographically‐locked convection facilitate both modeling and field campaign design to examine the general properties of active deep convection.
Global Impacts of El Niño on Terrestrial Moisture Recycling
Authors: Posada‐Marín José A. , Arias Paola A. , Jaramillo Fernando , Salazar Juan F.
Published: May 2023

The global impacts of El Niño on precipitation have been long‐recognized, but more understanding of the mechanisms behind this influence is needed. For instance, previous studies have largely overlooked the potential impacts of El Niño on terrestrial moisture recycling (TMR). We perform a 40‐year forward tracking simulation to derive a global climatology of recycled precipitation and use a composite analysis to investigate how El Niño affects TMR. We identify seven regions where the El Niño impact on TMR is most significant and find that, in these regions, changes in precipitation and TMR are directly related: they increase or decrease together. In addition, we find a marked latitudinal contrast between the Southern Hemisphere, where TMR increases during El Niño, and the Northern Hemisphere and the tropics, where it decreases. Our results indicate that the weakening and strengthening of TMR can be behind precipitation changes caused by El Niño globally.
Lunar Mantle Composition Based on Spectral and Geologic Analysis of Low‐Ca Pyroxene‐ and Olivine‐Rich Rocks Exposed on the Lunar Surface
Authors: Yamamoto Satoru , Nagaoka Hiroshi , Ohtake Makiko , Kayama Masahiro , Karouji Yuzuru , Ishihara Yoshiaki , Haruyama Junichi
Published: May 2023

We studied the lunar mantle composition based on the characteristics of low‐Ca pyroxene (LCP)‐rich and olivine‐rich rocks exposed on the lunar surface. Using data mining with SELENE (Kaguya) hyperspectral data, we found 531 sites with spectra dominated by an ultramafic LCP end‐member mineral, most of which are located in the Imbrium basin and the South Pole‐Aitken (SPA) basin. Stratigraphic analysis of each site revealed that LCP‐rich rock bodies are exposed on fresh geological features that are less affected by space‐weathering, such as steep slopes at peaks, and crater walls and ejecta deposits at smaller craters. We also found that, in the SPA and Imbrium basins, LCP‐rich bodies are more numerous and more widely distributed than olivine‐rich rocks, suggesting that LCP‐rich materials deep in the mantle were excavated during the formation of these huge basins. However, olivine‐rich rocks were abundant, and no LCP‐rich rocks were found in the Moscoviense, Crisium, and Humboldtianum basins, which are known to have almost‐zero crustal thicknesses, indicative of mantle excavation. Thus, our results suggest that the composition of rocks derived from the lunar mantle varies with the impact basin. Such a difference might indicate a layered structure of mantle composition, with the olivine‐rich upper mantle overlying the LCP‐rich mantle, a horizontal heterogeneity in the mantle composition, a regional heterogeneity in early lunar basaltic magmatism, or an impact melt origin. The layered structure or horizontal heterogeneity might have resulted from a mantle overturn caused by gravitational instability in the early stages of the lunar magma ocean.
Removing Numerical Pathologies in a Turbulence Parameterization Through Convergence Testing
Authors: Zhang Shixuan , Vogl Christopher J. , Larson Vincent E. , Bui Quan M. , Wan Hui , Rasch Philip J. , Woodward Carol S.
Published: May 2023

Discretized numerical models of the atmosphere are usually intended to faithfully represent an underlying set of continuous equations, but this necessary condition is violated sometimes by subtle pathologies that have crept into the discretized equations. Such pathologies can introduce undesirable artifacts, such as sawtooth noise, into the model solutions. The presence of these pathologies can be detected by numerical convergence testing. This study employs convergence testing to verify the discretization of the Cloud Layers Unified By Binormals (CLUBB) model of clouds and turbulence. That convergence testing identifies two aspects of CLUBB's equation set that contribute to undesirable noise in the solutions. First, numerical limiters (i.e., clipping) used by CLUBB introduce discontinuities or slope discontinuities in model fields. Second, nonlinear artificial diffusion employed for improving numerical stability can introduce unintended small‐scale features into the solution of the model equations. Smoothing the limiters and using linear artificial diffusion reduces the noise and restores the expected first‐order convergence in CLUBB's solutions. These model reformulations enhance our confidence in the trustworthiness of solutions from CLUBB by eliminating the unphysical oscillations in high‐resolution simulations. The improvements in the results at coarser, near‐operational grid spacing and timestep are also seen in cumulus cloud and dry turbulence tests. In addition, convergence testing is proven to be a valuable tool for detecting pathologies, including unintended discontinuities and grid dependence, in the model equation set.
A monolithically integrated microcantilever biosensor based on partially depleted SOI CMOS technology
Authors: Liu Yi , Tian Yuan , Lin Cong , Miao Jiahao , Yu Xiaomei
Published: May 2023

This paper presents a monolithically integrated aptasensor composed of a piezoresistive microcantilever array and an on-chip signal processing circuit. Twelve microcantilevers, each of them embedded with a piezoresistor, form three sensors in a Wheatstone bridge configuration. The on-chip signal processing circuit consists of a multiplexer, a chopper instrumentation amplifier, a low-pass filter, a sigma-delta analog-to-digital converter, and a serial peripheral interface. Both the microcantilever array and the on-chip signal processing circuit were fabricated on the single-crystalline silicon device layer of a silicon-on-insulator (SOI) wafer with partially depleted (PD) CMOS technology followed by three micromachining processes. The integrated microcantilever sensor makes full use of the high gauge factor of single-crystalline silicon to achieve low parasitic, latch-up, and leakage current in the PD-SOI CMOS. A measured deflection sensitivity of 0.98 × 10−6 nm−1 and an output voltage fluctuation of less than 1 μV were obtained for the integrated microcantilever. A maximum gain of 134.97 and an input offset current of only 0.623 nA were acquired for the on-chip signal processing circuit. By functionalizing the measurement microcantilevers with a biotin-avidin system method, human IgG, abrin, and staphylococcus enterotoxin B (SEB) were detected at a limit of detection (LOD) of 48 pg/mL. Moreover, multichannel detection of the three integrated microcantilever aptasensors was also verified by detecting SEB. All these experimental results indicate that the design and process of monolithically integrated microcantilevers can meet the requirements of high-sensitivity detection of biomolecules.
ExoDx prostate test as a predictor of outcomes of high-grade prostate cancer – an interim analysis
Authors: Tutrone Ronald , Lowentritt Ben , Neuman Brian , Donovan Michael J. , Hallmark Elliot , Cole T. Jeffrey , Yao Yiyuan , Biesecker Claire , Kumar Sonia , Verma Vinita , Sant Grannum R. , Alter Jason , Skog Johan
Published: May 2023

Background

Patient outcomes were assessed based on a pre-biopsy ExoDx Prostate (EPI) score at 2.5 years of the 5-year follow-up of ongoing prostate biopsy Decision Impact Trial of the ExoDx Prostate (IntelliScore).

Methods

Prospective, blinded, randomized, multisite clinical utility study was conducted from June 2017 to May 2018 (NCT03235687). Urine samples were collected from 1049 men (≥50 years old) with a PSA 2–10 ng/mL being considered for a prostate biopsy. Patients were randomized to EPI vs. standard of care (SOC). All had an EPI test, but only EPI arm received results during biopsy decision process. Clinical outcomes, time to biopsy and pathology were assessed among low (<15.6) or high (≥15.6) EPI scores.

Results

At 2.5 years, 833 patients had follow-up data. In the EPI arm, biopsy rates remained lower for low-risk EPI scores than high-risk EPI scores (44.6% vs 79.0%, p < 0.001), whereas biopsy rates were identical in SOC arm regardless of EPI score (59.6% vs 58.8%, p = 0.99). Also in the EPI arm, the average time from EPI testing to first biopsy was longer for low-risk EPI scores compared to high-risk EPI scores (216 vs. 69 days; p < 0.001). Similarly, the time to first biopsy was longer with EPI low-risk scores in EPI arm compared to EPI low-risk scores in SOC arm (216 vs 80 days; p < 0.001). At 2.5 years, patients with low-risk EPI scores from both arms had less HGPC than high-risk EPI score patients (7.9% vs 26.8%, p < 0.001) and the EPI arm found 21.8% more HGPC than the SOC arm.

Conclusions

This follow-up analysis captures subsequent biopsy outcomes and demonstrates that men receiving EPI low-risk scores (<15.6) significantly defer the time to first biopsy and remain at a very low pathologic risk by 2.5-years after the initial study. The EPI test risk stratification identified low-risk patients that were not found with the SOC.
Cognitive decline and risk of dementia in older adults after diagnosis of chronic obstructive pulmonary disease
Authors: Rosso Aldana , Månsson Tomas , Egervall Karl , Elmståhl Sölve , Overton Marieclaire
Published: May 2023

Cognitive screening has been proposed for older adults diagnosed with chronic obstructive pulmonary disease (COPD). Therefore, we examined the change over time in cognitive function and the risk of incident dementia in older adults after COPD diagnosis. A sample of 3,982 participants from the population-based cohort study Good Aging in Skåne was followed for 19 years, and 317 incident COPD cases were identified. The cognitive domains of episodic memory, executive function, and language were assessed using neuropsychological tests. Mixed models for repeated measures and a Cox model were implemented. Participants performed, on average, worse over time on all neuropsychological tests after COPD diagnosis in comparison to those without COPD, although statistical significance differences were only observed for episodic memory and language. The groups had a comparable risk of developing dementia. In conclusion, our results indicate that cognitive screening in the early stages of COPD may be of limited clinical relevance.
Assessment of efficacy and safety of advanced endoscopic irreversible electroporation catheter in the esophagus
Authors: Jeon Han Jo , Choi Hyuk Soon , Lee Jae Min , Kim Eun Sun , Keum Bora , Jeen Yoon Tae , Lee Hong Sik , Chun Hoon Jai , Jeong Seung , Kim Hong Bae , Kim Jong Hyuk
Published: May 2023

Nonthermal irreversible electroporation (NTIRE) is emerging as a promising tissue ablation technique. However, maintaining irreversible electroporation (IRE) electrodes against displacement during strong esophageal spasms remains an obstacle. The present study aimed to evaluate the efficacy and safety of newly designed balloon-type endoscopic IRE catheters. Six pigs were randomly allocated to each catheter group, and each pig was subjected to four ablations at alternating voltages of 1500 V and 2000 V. Esophagogastroscopy was performed during the IRE. The ability of balloon-type catheters to execute complete IRE with 40 pulses was assessed. The success rate was higher for the balloon-type catheter than that for the basket-type (12/12 [100%] vs. 2/12 [16.7%], p < 0.001). Following gross inspection and histologic analysis of the 1500-V vs. 2000-V balloon-type catheter revealed a larger mucosal damage area (105.3 mm2 vs. 140.8 mm2, p = 0.004) and greater damage depth (476 μm vs. 900 μm, p = 0.02). Histopathology of the ablated tissue revealed separated epithelium, inflamed lamina propria, congested muscularis mucosa, necrotized submucosa, and disorganized muscularis propria. Balloon-type catheters demonstrated efficacy, achieving full electrical pulse sequences under NTIRE conditions, and a safe histological profile below 2000 V (1274 V/cm). Optimal electrical conditions and electrode arrays pose ongoing challenges.
An injectable copolymer of fatty acids (ARA 3000 BETA) as a promising treatment for osteoarthritis
Authors: Toupet Karine , Jorgensen Christian , Noël Danièle
Published: May 2023

Osteoarthritis (OA) is the most prevalent rheumatic disease and a fast growing cause of disability. Current pharmacological treatments include antalgics and non-steroid anti-inflammatory drugs to control pain and inflammation as well as slow acting drugs such as intra-articular (IA) administration of hyaluronic acid. Oral supplementation or diet rich in polyunsaturated free fatty acids are proposed but evidence for benefit is still under debate. We here investigated the therapeutic potential of ARA 3000 BETA, an injectable copolymer of fatty acids, at the structural level in OA. Collagenase-induced osteoarthritis model was induced in C57BL/6 mice by collagenase injection into knee joint. Mice were treated with one or two IA or four intra-muscular injections (IM) of ARA 3000 BETA. At sacrifice, knee joints were recovered for cartilage analysis by confocal laser scanning microscopy (CLSM) and bone analysis by micro-computed tomography system. OA histological scoring was performed after safranin O/fast green staining. Histological analysis revealed a protective effect against cartilage degradation in treated knee joints after IM and IA administration. This was confirmed by CLSM with a significant improvement of all articular cartilage parameters, including thickness, volume and surface degradation whatever the administration route. A slight protective effect was also noticed on subchondral bone parameters and knee joint calcification after IM administration and to a lesser extent, two IA injections. We demonstrated the therapeutic efficacy of injectable ARA 3000 BETA in OA with a protection against cartilage and bone alterations providing the proof-of-concept that clinical translation might be envisioned to delay disease progression.
Clinical spectrum and prognosis of pathologically confirmed atypical tumefactive demyelinating lesions
Authors: Zhang Yajing , Zhang Ting , Zhang Xuebin , Yan Xiaoling , Lei Jing , Liu Ran , Yang Yun , Zhang Chao , Zhang Jun , Zhang Ying , Yue Wei
Published: May 2023

To describe the clinical spectrum and prognosis of atypical tumefactive demyelinating lesions (TDLs), which were confirmed by pathology. A total of 11 patients were diagnosed with atypical TDLs confirmed by brain biopsy and surgery between January 2006 and December 2017. The clinical spectrum and prognosis in these patients were analyzed. The patients’ ages ranged from 29 to 62 years, with a mean age of 48.9 years; 72.7% were males. The Expanded Disability Status Scale (EDSS) of the patients with first onset was 2.36. Most of the patients started with limb numbness and weakness (45.5%) or alalia (27.2%). The mean time from symptom onset to biopsy or surgery was 12.9 days (3–30 days). Most of the patients had solitary lesions (72.7%), supratentorial lesions (90.9%, particularly predominant in the frontal, temporal, and parietal lobes), moderate edema (63.6%), mild mass effect (54.5%), and patchy lesions (54.5%). Among them, three patients were positive for myelin basic protein (MBP) and one patient was positive for myelin oligodendrocyte glycoprotein (MOG). The patients were followed up for an average of 6.9 years (2–14 years), and recurrent TDLs were observed in 2 patients. Except for the 2 patients who relapsed, only 1 of the 9 patients died; the other 8 patients improved or maintained the status quo (the EDSS scores were lower or unchanged). The patients did not have any serious nervous system injury at onset, and the main presentation included extremity weakness, headache or dizziness, and alalia. The most common form was patchy on MRI enhancement. Cerebrospinal fluid and demyelination test can be an indicator of TDLs, and seizures may be a poor prognostic indicator. Most atypical TDLs have monophasic courses and good outcomes. The effect of neurosurgery alone was good in our group, and the effect of surgery on atypical TDLs can be further studied.
The impact of floating photovoltaic power plants on lake water temperature and stratification
Authors: Ilgen Konstantin , Schindler Dirk , Wieland Stefan , Lange Jens
Published: May 2023

Floating photovoltaics (FPV) refers to photovoltaic power plants anchored on water bodies with modules mounted on floats. FPV represents a relatively new technology in Europe and is currently showing a rapid growth in deployment. However, effects on thermal characteristics of lakes are largely unknown, yet these are crucial for licensing and approval of such plants. Here, we quantify FPV impacts on lake water temperature, energy budget and thermal stratification of a lake through measurements of near-surface lateral wind flow, irradiance, air and water temperatures at one of the largest commercial German facilities, situated on a 70 m deep dredging lake in the Upper Rhine Valley, South-West Germany. Underneath the FPV facility, a 73% reduction in irradiance on the lake surface and an average 23% reduction in near-surface wind speed at module height are detected. A three month data set is then used to set up the General Lake Model and simulate scenarios of different FPV occupancies and changing climatic conditions. We observe that a lake coverage with FPV result in a more unstable and shorter thermal stratification during summer, which could mitigate the effects of climate change. The reduction of water temperatures follows a non-linear relationship with increased FPV occupancy. A sensitivity analysis showed that an increased wind reduction by FPV can have a considerable impact on the thermal properties of the lake. However, measurements only suggest small deviations with regard to the thermal properties of the investigated lake. These findings can be used in approval procedures and allow for a more accurate assessment of environmental impacts of future installations.
Classification tasks using input driven nonlinear magnetization dynamics in spin Hall oscillator
Authors: Mohan John Rex , Mathew Arun Jacob , Nishimura Kazuma , Feng Ruoyan , Medwal Rohit , Gupta Surbhi , Rawat Rajdeep Singh , Fukuma Yasuhiro
Published: May 2023

The inherent nonlinear magnetization dynamics in spintronic devices make them suitable candidates for neuromorphic hardware. Among spintronic devices, spin torque oscillators such as spin transfer torque oscillators and spin Hall oscillators have shown the capability to perform recognition tasks. In this paper, with the help of micromagnetic simulations, we model and demonstrate that the magnetization dynamics of a single spin Hall oscillator can be nonlinearly transformed by harnessing input pulse streams and can be utilized for classification tasks. The spin Hall oscillator utilizes the microwave spectral characteristics of its magnetization dynamics for processing a binary data input. The spectral change due to the nonlinear magnetization dynamics assists in real-time feature extraction and classification of 4-binary digit input patterns. The performance was tested for the classification of the standard MNIST handwritten digit data set and achieved an accuracy of 83.1% in a simple linear regression model. Our results suggest that modulating time-driven input data can generate diverse magnetization dynamics in the spin Hall oscillator that can be suitable for temporal or sequential information processing.
Diabetes and obesity and risk of pyogenic liver abscess
Authors: Wang Jiun-Ling , Hsu Chun-Ru , Wu Chieh-Yin , Lin Hsien-Ho
Published: May 2023

Few literatures discussed the relationship of glycemic control and body mass index (BMI) with the risk of pyogenic liver abscess. We conducted a population-based cohort study using participants of a community-based health screening program in Taiwan from 2005 to 2008 (n = 125,865). Information on fasting plasma glucose (FPG), BMI, and other potential risk factors of liver abscess were collected at baseline. Incidence of pyogenic liver abscess was ascertained using inpatient records from the National Health Insurance database. During a median 8.6 years of followed up, 192 incident cases of pyogenic liver abscess were reported. The incidence rate of pyogenic liver abscess was 70.2 and 14.7 per 100,000 in the diabetic and non-diabetic population respectively. In multivariable Cox regression analysis, the adjusted hazard ratio (HR) was 2.18 (95% confidence interval (CI) 1.22–3.90) in patients with diabetes with good glycemic control (FPG ≤ 130 mg/dl) and 3.34 (95% CI 2.37–4.72) in those with poor glycemic control (FPG > 130 mg/dl), when compared with non-diabetics. In the dose–response analysis, the risk of liver abscess increased monotonically with increasing FPG. After adjusting for diabetes and other comorbidities, overweight (25 ≤ BMI < 30) (adjusted HR: 1.43, 95% CI 1.05–1.95) and obese (BMI ≥ 30) (adjusted HR: 1.75, 95% CI 1.09–2.81) populations had a higher risk of liver abscess when compared to people with normal weight. Diabetes, especially poorly controlled disease, and high BMI were associated with higher risk of pyogenic liver abscess. Improving glycemic control and weight reduction may reduce the risk of developing pyogenic liver abscess.
Impacts of algae supplements (Arthrospira & Chlorella) on growth, nutrient variables, intestinal efficacy, and antioxidants in New Zealand white rabbits
Authors: El Basuini Mohammed F. , Khattab Ahmed A. A. , Hafsa Salma H. Abu , Teiba Islam I. , Elkassas Nabila E. M. , El-Bilawy Emad H. , Dawood Mahmoud A. O. , Atia Safaa Elsayed Salah
Published: May 2023

An 8-week trial to examine the impacts of Arthrospira platensis and Chlorella vulgaris on the growth, nutrient aspects, intestinal efficacy, and antioxidants of 75 New Zealand white male rabbits (initial body weight = 665.93 ± 15.18 g). Herein the study was designed in one-way ANOVA to compare the effects of the two algae species with two levels of supplementations in the feeds of New Zealand white rabbits. The rabbits were divided into five groups (n = 15/group), where the first group was allocated as the control group (Ctrl) while the second and third groups received A. platensis at 300 or 500 mg/kg diet (Ap300 or Ap500). The fourth and fifth groups fed C. vulgaris at 300 or 500 mg/kg diet (Ch300 or Ch500). The basal diet rabbits exhibited the lowest values of weight, lipase, protease, and the highest feed conversion ratio, which improved noticeably with algae addition, particularly with Ap500, Ch300, and Ch500. All tested groups showed normal intestinal structure. Amylase potency, hematological indicators, and serum biochemistry revealed non-significant variation except for a higher serum total protein and lower total cholesterol in algal groups. The best GPx existed in groups fed algal diets, while favorable SOD and CAT efficiency occurred at the higher level of Arthrospira and both levels of Chlorella. In conclusion, incorporating Arthrospira or Chlorella in the diet of New Zealand white rabbits improved performance, nutrient utilization, intestinal efficacy, and antioxidants. Arthrospira (Ap500) and Chlorella (Ch300 or Ch500) have almost the same beneficial effect on rabbit performance.
Cannabidiol inhibits neuroinflammatory responses and circuit-associated synaptic loss following damage to a songbird vocal pre-motor cortical-like region
Authors: Tripson Mark , Litwa Karen , Soderstrom Ken
Published: May 2023

The non-euphorigenic phytocannabinoid cannabidiol (CBD) has been used successfully to treat childhood-onset epilepsies. These conditions are associated with developmental delays that often include vocal learning. Zebra finch song, like language, is a complex behavior learned during a sensitive period of development. Song quality is maintained through continuous sensorimotor refinement involving circuits that control learning and production. Within the vocal motor circuit, HVC is a cortical-like region that when partially lesioned temporarily disrupts song structure. We previously found CBD (10 mg/kg/day) improves post-lesion vocal recovery. The present studies were done to begin to understand mechanisms possibly responsible for CBD vocal protection. We found CBD markedly reduced expression of inflammatory mediators and oxidative stress markers. These effects were associated with regionally-reduced expression of the microglial marker TMEM119. As microglia are key regulators of synaptic reorganization, we measured synapse densities, finding significant lesion-induced circuit-wide decreases that were largely reversed by CBD. Synaptic protection was accompanied by NRF2 activation and BDNF/ARC/ARG3.1/MSK1 expression implicating mechanisms important to song circuit node mitigation of oxidative stress and promotion of synaptic homeostasis. Our findings demonstrate that CBD promotes an array of neuroprotective processes consistent with modulation of multiple cell signaling systems, and suggest these mechanisms are important to post-lesion recovery of a complex learned behavior.
Comparison of conventional and unconventional obesity indices associated with new-onset hypertension in different sex and age populations
Authors: Zhang Xueyao , Li Guangxiao , Shi Chuning , Tian Yichen , Zhang Linlin , Zhang Hongyu , Sun Yingxian
Published: May 2023

We aimed to compare the relationship between hypertension and obesity-related anthropometric indices (waist circumference [WC], waist-height ratio, waist-hip ratio [WHR], and body mass index; unconventional: new body shape index [ABSI] and body roundness index [BRI]) to identify best predictors of new-onset hypertension. The study included 4123 adult participants (2377 women). Hazard ratios (HRs) and 95% confidence intervals (CIs) were determined using a Cox regression model to estimate the risk of new-onset hypertension with respect to each obesity index. In addition, we assessed the predictive value of each obesity index for new-onset hypertension using area under the receiver operating characteristic curve (AUC) after adjusting for common risk factors. During the median follow-up of 2.59 years, 818 (19.8%) new hypertension cases were diagnosed. The non-traditional obesity indices BRI and ABSI had predictive value for new-onset hypertension; however, they were not better than the traditional indexes. WHR was the best predictor of new-onset hypertension in women aged ≤ 60 and > 60 years, with HRs of 2.38 and 2.51 and AUCs of 0.793 and 0.716. However, WHR (HR 2.28, AUC = 0.759) and WC (HR 3.24, AUC = 0.788) were the best indexes for predicting new-onset hypertension in men aged ≤ 60 and > 60 years, respectively.
Evaluation on displacement risks of dismantling temporary lining in tunnel and optimization on temporary lining configuration
Authors: Zhang Huijian , Liu Kai , Cao Pan , Liu Gongning
Published: May 2023

In tunnel engineering, the temporary lining is adopted as an effective countermeasure in mitigating tunnel failure potential, often featured by extra-large cross-sections and/or driven through weak ground conditions. However, dismantling temporary linings negatively impacts primary linings. In this paper, the comprehensive research is conducted on the displacement risk caused by dismantling temporary lining based on two alternative tunneling methods (TM-1 and TM-2). Besides, the following three influence factors are taken into consideration: the axial forces in temporary linings, the thickness of preliminary linings, and the deformation modulus of ground. After that, the tunneling method optimization plan is proposed from the view of these three influence factors. The results show that TM-1 always induces invert uplift, whereas TM-2 mainly brings about invert uplift or sidewall bulging depending on which transverse or vertical linings are dominant in terms of axial force values. For TM-2, the axial force in transverse linings can suppress the development of maximum deformation increment (MDI) value at invert when the axial forces in transverse linings are smaller than those in vertical linings. It is also found that with the further increase of the axial force in transverse linings in TM-2, MDI relocates to the sidewall. Moreover, on the basis of the displacement risk evaluations, an optimization on the temporary lining configurations has been developed by replacing temporary linings with pre-tension anchor cables to reduce the risk of dismantling temporary linings. All the research results can provide some important reference for the similar tunnel engineering in the future.
A track record of Au–Ag nanomelt generation during fluid-mineral interactions
Authors: Domínguez-Carretero Diego , González-Jiménez José María , Proenza Joaquín A. , Villanova-de-Benavent Cristina , Llovet Xavier , Garcia-Casco Antonio
Published: May 2023

Recent studies have reported the significant role of Au-bearing nanoparticles in the formation of hydrothermal gold deposits. Despite the ever-increasing understanding of the genesis and stability of Au-bearing nanoparticles, it is still unknown how they behave when exposed to hydrothermal fluids. Here, we study the nanostructural evolution of Au–Ag nanoparticles hosted within Co-rich diarsenides and sulfarsenides of a natural hydrothermal deposit. We use high-resolution transmission electron microscopy to provide a singular glimpse of the complete melting sequence of Au–Ag nanoparticles exposed to the hydrothermal fluid during coupled dissolution–precipitation reactions of their host minerals. The interaction of Au–Ag nanoparticles with hydrothermal fluids at temperatures (400–500 ºC) common to most hydrothermal gold deposits may promote melting and generation of Au–Ag nanomelts. This process has important implications in noble metal remobilization and accumulation during the formation of these deposits.
Different electrostatic forces drive the binding kinetics of SARS-CoV, SARS-CoV-2 and MERS-CoV Envelope proteins with the PDZ2 domain of ZO1
Authors: Pennacchietti Valeria , Toto Angelo
Published: May 2023

The Envelope protein (E) is a structural protein encoded by the genome of SARS-CoV, SARS-CoV-2 and MERS-CoV Coronaviruses. It is poorly present in the virus but highly expressed in the host cell, with prominent role in virus assembly and virulence. The E protein possesses a PDZ-binding motif (PBM) at its C terminus that allows it to interact with host PDZ domain containing proteins. ZO1 is a key protein in assembling the cytoplasmic plaque of epithelial and endothelial Tight Junctions (TJs) as well as in determining cell differentiation, proliferation and polarity. The PDZ2 domain of ZO1 is known to interact with the Coronaviruses Envelope proteins, however the molecular details of such interaction have not been established. In this paper we directly measured, through Fluorescence Resonance Energy Transfer and Stopped-Flow methodology, the binding kinetics of the PDZ2 domain of ZO1 with peptides mimicking the C-terminal portion of the Envelope protein from SARS-CoV, SARS-CoV-2 and MERS-CoV in different ionic strength conditions. Interestingly, the peptide mimicking the E protein from MERS-CoV display much higher microscopic association rate constant with PDZ2 compared to SARS-CoV and SARS-CoV-2 suggesting a stronger contribution of electrostatic forces in the early events of binding. A comparison of thermodynamic and kinetic data obtained at increasing ionic strengths put in evidence different contribution of electrostatics in the recognition and complex formation events for the three peptides. Our data are discussed under the light of available structural data of PDZ2 domain of ZO1 and of previous works about these protein systems.
AgSCN as a new hole transporting material for inverted perovskite solar cells
Authors: Elseman Ahmed Mourtada
Published: May 2023

A novel HTM based on silver thiocyanate (AgSCN) was designed to be useable in p-i-n perovskite solar cells (PSCs). With mass yield, the AgSCN was synthesized in the lab and elucidated by XRD, XPS, Raman spectroscopy, UPS, and TGA. The production of thin, highly conformal AgSCN films that allow for quick carrier extraction and the collection was made possible by a fast solvent removal approach. Photoluminescence experiments have shown that adding AgSCN has improved the ability to transfer charges between HTL and perovskite layer compared to PEDOT:PSS at the interface. Crystallographic discrepancies in the polycrystalline perovskite film are discovered upon further examination of the film's microstructure and morphology, pointing to the development of templated perovskite on the surface of AgSCN. In comparison to devices due to the well-known PEDOT:PSS, the open circuit voltage (VOC) is increased by AgSCN with its high work function by 0.1–1.14 V (1.04 V for PEDOT:PSS). With a power conversion efficiency (PCE) of 16.66%, a high-performance PSCs are effectively generated using CH3NH3PbI3perovskite compared to 15.11% for controlled PEDOT:PSS devices.The solution-processed inorganic HTL was demonstrated employing straightforward in order to build durable and effective flexible p-i-n PSCs modules or their use as a front cell in hybrid tandem solar cells.
Action spectrum for reorientations in bacteriorhodopsin of purple membrane in suspension
Authors: Mostafa Hamdy I. A.
Published: May 2023

In the present study, the dependency of purple membrane (PM) dielectric responses on the wavelength of light in the range 380–750 nm has showed meaningful changes about the rotation of PM in suspension and about the rotation of bacteriorhodopsin (bR) trimer inside PM, as well. The action spectrum of PM random walk substantiates the existence of two states of bR. One of them (blue edge-state) lies at the blue edge and the other (red edge-state) at the red edge of the visible absorption of bR. The results might bear on correlation of these bands to some bR photocycle intermediates or bR photoproducts. The results implicate the protein–chromophore interactions that eventually underlie protein–lipid interactions. Disrupting the protein–lipid contact during the illumination with light of wavelength in ranges of (410–470 nm) and (610–720 nm) has resulted in emergence of distinct dielectric dispersion at 0.06–0.08 MHz which is comparable to the size of bR trimer or monomer.The work reports on the chromatic adaptation of bR in view of the dielectric spectral parameters of PM. It aimed to explore a correlation seemingly found between the light wavelength and the relaxations of bR trimer inside PM. Changes in rotational diffusion of bR trimer upon blue and red light illumination can influence the three dimensional data storage based on bR, which may implicate bR in bioelectronics.
Computational drug repurposing of Akt-1 allosteric inhibitors for non-small cell lung cancer
Authors: Baby Krishnaprasad , Maity Swastika , Mehta Chetan Hasmukh , Nayak Usha Y. , Shenoy Gautham G. , Pai Karkala Sreedhara Ranganath , Harikumar Kuzhuvelil B. , Nayak Yogendra
Published: May 2023

Non-small cell lung carcinomas (NSCLC) are the predominant form of lung malignancy and the reason for the highest number of cancer-related deaths. Widespread deregulation of Akt, a serine/threonine kinase, has been reported in NSCLC. Allosteric Akt inhibitors bind in the space separating the Pleckstrin homology (PH) and catalytic domains, typically with tryptophan residue (Trp-80). This could decrease the regulatory site phosphorylation by stabilizing the PH-in conformation. Hence, in this study, a computational investigation was undertaken to identify allosteric Akt-1 inhibitors from FDA-approved drugs. The molecules were docked at standard precision (SP) and extra-precision (XP), followed by Prime molecular mechanics—generalized Born surface area (MM-GBSA), and molecular dynamics (MD) simulations on selected hits. Post XP-docking, fourteen best hits were identified from a library of 2115 optimized FDA-approved compounds, demonstrating several beneficial interactions such as pi–pi stacking, pi-cation, direct, and water-bridged hydrogen bonds with the crucial residues (Trp-80 and Tyr-272) and several amino acid residues in the allosteric ligand-binding pocket of Akt-1. Subsequent MD simulations to verify the stability of chosen drugs to the Akt-1 allosteric site showed valganciclovir, dasatinib, indacaterol, and novobiocin to have high stability. Further, predictions for possible biological interactions were performed using computational tools such as ProTox-II, CLC-Pred, and PASSOnline. The shortlisted drugs open a new class of allosteric Akt-1 inhibitors for the therapy of NSCLC.
Life cycle environmental impact assessment for battery-powered electric vehicles at the global and regional levels
Authors: Zhang Hongliang , Xue Bingya , Li Songnian , Yu Yajuan , Li Xi , Chang Zeyu , Wu Haohui , Hu Yuchen , Huang Kai , Liu Lei , Chen Lai , Su Yuefeng
Published: May 2023

As an important part of electric vehicles, lithium-ion battery packs will have a certain environmental impact in the use stage. To analyze the comprehensive environmental impact, 11 lithium-ion battery packs composed of different materials were selected as the research object. By introducing the life cycle assessment method and entropy weight method to quantify environmental load, a multilevel index evaluation system was established based on environmental battery characteristics. The results show that the Li–S battery is the cleanest battery in the use stage. In addition, in terms of power structure, when battery packs are used in China, the carbon footprint, ecological footprint, acidification potential, eutrophication potential, human toxicity cancer and human toxicity noncancer are much higher than those in the other four regions. Although the current power structure in China is not conducive to the sustainable development of electric vehicles, the optimization of the power structure is expected to make electric vehicles achieve clean driving in China.
Improving video surveillance systems in banks using deep learning techniques
Authors: Zahrawi Mohammad , Shaalan Khaled
Published: May 2023

In the contemporary world, security and safety are significant concerns for any country that wants to succeed in tourism, attracting investors, and economics. Manually, guards monitoring 24/7 for robberies or crimes becomes an exhaustive task, and real-time response is essential and helpful for preventing armed robberies at banks, casinos, houses, and ATMs. This paper presents a study based on real-time object detection systems for weapons auto-detection in video surveillance systems. We propose an early weapon detection framework using state-of-the-art, real-time object detection systems such as YOLO and SSD (Single Shot Multi-Box Detector). In addition, we considered closely reducing the number of false alarms in order to employ the model in real-life applications. The model is suitable for indoor surveillance cameras in banks, supermarkets, malls, gas stations, and so forth. The model can be employed as a precautionary system to prevent robberies by implying the model in outdoor surveillance cameras.