bluuebunny/crossref_metadata_2025 huggingface dataset:
Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline
Authors: Nordenström A , Ahmed S F , van den Akker E , Blair J , Bonomi M , Brachet C , Broersen L H A , Claahsen-van der Grinten H L , Dessens A B , Gawlik A , Gravholt C H , Juul A , Krausz C , Raivio T , Smyth A , Touraine P , Vitali D , Dekkers O M
Published: March 2022

An Endo-European Reference Network guideline initiative was launched including 16 clinicians experienced in endocrinology, pediatric and adult and 2 patient representatives. The guideline was endorsed by the European Society for Pediatric Endocrinology, the European Society for Endocrinology and the European Academy of Andrology. The aim was to create practice guidelines for clinical assessment and puberty induction in individuals with congenital pituitary or gonadal hormone deficiency. A systematic literature search was conducted, and the evidence was graded according to the Grading of Recommendations, Assessment, Development and Evaluation system. If the evidence was insufficient or lacking, then the conclusions were based on expert opinion. The guideline includes recommendations for puberty induction with oestrogen or testosterone. Publications on the induction of puberty with follicle-stimulation hormone and human chorionic gonadotrophin in hypogonadotropic hypogonadism are reviewed. Specific issues in individuals with Klinefelter syndrome or androgen insensitivity syndrome are considered. The expert panel recommends that pubertal induction or sex hormone replacement to sustain puberty should be cared for by a multidisciplinary team. Children with a known condition should be followed from the age of 8 years for girls and 9 years for boys. Puberty induction should be individualised but considered at 11 years in girls and 12 years in boys. Psychological aspects of puberty and fertility issues are especially important to address in individuals with sex development disorders or congenital pituitary deficiencies. The transition of these young adults highlights the importance of a multidisciplinary approach, to discuss both medical issues and social and psychological issues that arise in the context of these chronic conditions.
Tecnologías de caza en la localidad arqueológica Laguna Azul de la meseta de Somuncurá: estudios experimentales y traceológicos
Authors: Lynch Virginia , Salgado Emmanuel , Vargas Gariglio Jorgelina , Daniele Gonzalo , Hermo Darío Omar
Published: March 2022

La localidad arqueológica Laguna Azul (LA) registra numerosas estructuras de piedra con morfologías variables y fechados del Holoceno Tardío (ca. 1906 ± 26 BP y 1756 ± 28 años AP). La presencia de gran cantidad de puntas de proyectil en las mismas con diferentes etapas de manufactura y diseño, nos ha llevado a generar interrogantes en cuantos a los rastros de uso y descarte de estos elementos.

En este trabajo se presenta el protocolo experimental y los resultados alcanzados mediante la utilización de réplicas de cabezales líticos, teniendo en consideración los diseños identificados en LA y uso de materias primas locales. Esto se llevó a cabo para incrementar el conocimiento acerca de estos diseños y su resistencia al impacto; junto con el análisis y registro de rastros generados por manufactura, uso y descarte de este tipo de tecnología a nivel microscópico.

El desarrollo de ésta primera etapa experimental permitió generar bases interpretativas de variables y verificación de hipótesis, al igual que la observación de la performance de diversos elementos componentes en una situación controlada.
Buscando a los orfebres andinos en el noroeste argentino. Una aproximación inicial desde el trabajo experimental en metales y el análisis funcional de rastros
Authors: Gaal Erico German , De Angelis Hernán , Chesini-Remic Andrés
Published: March 2022

En el valle de Yocavil (provincia de Catamarca, noroeste de la Argentina) se localiza el sitio arqueológico Rincón Chico 15, un taller metalúrgico que estuvo en actividad desde épocas preincaicas hasta el contacto hispano-indígena y que posee importantes características para los Andes Meridionales. Los trabajos realizados en el sitio han permitido estudiar numerosos aspectos de la producción metalúrgica en la región, como la oferta de recursos, la caracterización tecnológica y estilística de los objetos metálicos, la producción de la cerámica, así como la subsistencia. Sin embargo, se desconoce por completo el papel desempeñado por los artefactos líticos en las distintas etapas de la producción de bienes metálicos de bronce estannífero, que fue de gran importancia en el taller y en el mundo andino prehispánico. Aquí abordamos dicha cuestión por medio de una aproximación tecnofuncional y experimental. Un abordaje de este tipo nunca fue realizado en la arqueología local y posee importantes implicancias para los Andes Meridionales
Mental Health Status and Health-Promoting Lifestyle Behaviors among Call Center Employees
Authors: Oh Hyunjin , Boo Sunjoo
Published: March 2022

Background: Call center employees experience high levels of occupational stress and other mental health issues. This study aimed to examine the relationship between mental health status and health-promoting lifestyles among call center employees.Methods: A secondary data analysis from a descriptive cross-sectional study of 302 call center employees was conducted. Call center employees were asked to complete the Depression Anxiety Stress Scale (DASS) and the Health Promoting Lifestyle Profile-II (HPLP-II).Results: Participants’ overall DASS score was 23.87±13.98 out of 63. Among the six subscales of the HPLP-II, participants’ highest scores were for interpersonal relations, spiritual growth, and stress management, whereas physical activity had the lowest score. Participants with a severe level of mental health issues (i.e., depression, anxiety, and stress) reported lower levels of health-promoting lifestyle behaviors, especially in the areas of physical activity, spiritual growth, interpersonal relationships, and stress management.Conclusions: As call center service sectors increase in modern industries, so does the need to address the physical and mental health needs of its employees. Healthcare providers and organizations should closely and routinely monitor employee’s levels of depression, anxiety, and stress and develop organizational and health-related policies for the call center sector. Additionally, the development and implementation of health-related interventions to promote healthy lifestyle behaviors is critical for call center employees.
Association of Resting Heart Rate and Dyslipidemia and Diabetes in 2018 National Health and Nutrition Examination Survey
Authors: Heo An-Sik , Lee Jung-Chul , Kim Maeng-Kyu
Published: March 2022

Background: As a risk factor for diabetes, there are many evidences for physical characteristics and lifestyle habits. There are studies showing that resting heart rate is also related, but evidence is still lacking. Therefore, this study attempted to determine the effect of resting heart rate on diabetes.Methods: The subject of this study was analyzed with 6,622 people who had fasting blood glucose test data out of a total of 7,993 people who participated in the 7th National Health and Nutrition Survey. Fasting blood glucose above 126 mg/dL was defined as a diabetic group and a multiple logistic regression analysis was used. General characteristics, lifestyle and blood chemistry test results were adjusted to investigate the association with diabetes according to the resting heart rate level in the subjects.Results: The risk of diabetes according to the resting heart rate level was 1.434 times in the 2nd quartile, 1.714 times in the 3rd and 1.785 times in the 4th, compared to the 1st quartile. In model 4, except for the 2nd, which was not significant the analysis with all related variables adjusted for the risk rate in the 3rd and 4th order showed that the risk rate increased to 2.364 times and 3.477 times, respectively as the resting heart rate increased.Conclusions: This study shows that high resting heart rate is associated with increased diabetes, and suggests that high heart rate, along with other known risk factors, may be a useful tool in predicting diabetes risk.
Systematic Review of Eating Disorder Interventions for Type 1 Diabetes Mellitus
Authors: Park Hye-Ryeon , Park So-Yeon , Ju Hyeon Ok
Published: March 2022

Background: Although there are various interventions for eating disorders in type 1 diabetes patients, it is difficult to interpret them comprehensively. The purpose of this study is to analyze eating disorder intervention studies in type 1 diabetes patients and to compare the characteristics of each study.Methods: For this study, PICOTS-SD was established. We searched studies published in Korean and English from 2000 to 2020 in KCI, RISS, NDSL, KISS, MEDLINE, CINAHL, Pubmed, and Embase.Results: For the intervention of eating disorders in patients with type 1 diabetes, psycho-education and self-compassion programs were implemented. The intervention period varied from 4 to 6 weeks, and physiological variables, eating disorder variables, and emotional variables were used interventions. But the number of participants was small and the results of the study were inconsistent.Conclusions: Through this study, the possibility of resolving the difficulties of eating disorder intervention in type 1 diabetes patients was confirmed. In the future, more randomized controlled trials with larger samples are needed to extend the evidence base.
Determinants of Bilateral Trade Balance Between Georgia and China
Authors: Dilanchiev Azer , Taktakishvili Tengiz
Published: March 2022

This paper aims to empirically examine the drivers of the bilateral balance of the trade model for the Georgian-Chinese economy from 2000 to 2020 and the influence of the Georgia-China free trade agreement on the Georgian-Chinese balance of trade. The Error Correction Model (ECM) of the ARDL was used to see if the balance of trade and its predictors have a long-term relationship. One of the ARDL’s defining properties is that it may be utilized in circumstances when there is minimal data, regardless of the level of variable integration. According to the findings, a perceived effective exchange rate has a statistically significant positive impact on the balance of trade in the long run and a statistically significant negative impact on the balance of trade in the short run. The output is shaped to favor the presence of the elasticity attitude’s J-Curve impact. The study also found that the comparative supply of money (MS) and GDP have only a minor impact on the trade balance in the medium and long run. The sponging and monetary methods are ineffective in characterizing the bilateral trade deficit between Georgia and China.
Mobilization Safety of Critically Ill Children
Authors: LaRosa Jessica M. , Nelliot Archana , Zaidi Munfarid , Vaidya Dhananjay , Awojoodu Ronke , Kudchadkar Sapna R.
Published: March 2022

BACKGROUND

Children in PICUs experience negative sequelae of immobility; however, interprofessional staff concerns about safety are a barrier to early mobilization. Our objective was to determine the safety profile of early mobilization in PICU patients.

METHODS

We conducted a secondary analysis of a 2-day study focused on physical rehabilitation in 82 PICUs in 65 US hospitals. Patients who had ≥72-hour admissions and participated in a mobility event were included. The primary outcome was occurrence of a potential safety event during mobilizations.

RESULTS

On 1433 patient days, 4658 mobility events occurred with a potential safety event rate of 4% (95% confidence interval [CI], 3.6%–4.7%). Most potential safety events were transient physiologic changes. Medical equipment dislodgement was rare (0.3%), with no falls or cardiac arrests. Potential safety event rates did not differ by patient age or sex. Patients had higher potential safety event rates if they screened positive for delirium (7.8%; adjusted odds ratio, 5.86; 95% CI, 2.17–15.86) or were not screened for delirium (4.7%; adjusted odds ratio, 3.98; 95% CI, 1.82–8.72). There were no differences in potential safety event rates by PICU intervention, including respiratory support or vasoactive support.

CONCLUSIONS

Early PICU mobilization has a strong safety profile and medical equipment dislodgement is rare. No PICU interventions were associated with increased potential safety event rates. Delirium is associated with higher potential safety event rates. These findings highlight the need to improve provider education and confidence in mobilizing critically ill children.
Scrotal dog bite and mismatch between the skin and testis injury: a case report and review of literature
Authors: Bahoosh Masoud , Akhavizadegan Hamed
Published: March 2022

Dog bite injury to the genitalia is a rare condition, regarding which most of the studies have focused on prevention of infection and management of severe cases; and small, superficial lacerations have not been taken into consideration. We present a case of a patient whose testis was severely injured with minimal scrotal injury and without significant clinical findings other than pain. We found two other case reports with similar features during review of the literature. We suggest that in case of genital dog bite, regardless of the lesion size and appearance, imaging is necessary to make sure that the testes, corpus cavernosum, and urethra are intact.
Assessing the safety of interrogating cardiac-implantable electronic devices with brand-mismatched remote interrogators: a pilot study
Authors: Le Tinh , Neuenschwander James , Cordial Parker , Sankoe Mackenzie , Parekh Ankur , Hiestand Brian , Peacock WF
Published: March 2022

Objective Remote cardiac implantable electronic device (CIED) interrogators, originally developed for home use, have been proven to be efficacious in clinical settings, especially emergency departments. Concern exists that attempting to interrogate a CIED with the remote interrogator of a different brand, i.e., a brand-mismatched interrogator, may cause device malfunction. The aim of this study was to determine if intentionally attempting to interrogate a CIED with a brand-mismatched remote interrogator resulted in device malfunction.Methods A total of 75 ex vivo CIEDs manufactured by various companies underwent attempted interrogation by a brand-mismatched remote interrogator. CIED settings were compared before and after attempted mismatch interrogation. A total of 30 in vivo CIEDs were then randomized for an attempted 2-minute mismatched remote interrogation by one of the two possible mismatched remote interrogators. CIED settings were compared before and after attempted mismatch interrogation.Results Of 150 ex vivo brand-mismatched interrogations, no device setting changes or malfunctions occurred; no remote interrogators connected to a mismatched CIED, and no devices were turned off. In the 30 patients undergoing brand-mismatched interrogations, the mean (standard deviation) age was 71.6 ( ± 14.7) years, 16 (53%) were male, with 24 pacemakers (80%), four pacemaker/implantable cardioverter defibrillators (13%), and two implantable cardioverter defibrillators (7%). Of the 30 mismatched interrogations performed, no device setting changes or malfunctions occurred; no remote interrogators connected to a mismatched CIED, and no devices turned off.Conclusion In a total 180 attempted brand-mismatched CIED interrogations, no CIED malfunctions occurred. This suggests that the use of remote CIED interrogators when device manufacturer is unknown is unlikely to result in adverse CIED-related events.
Effect of fever or respiratory symptoms on leaving without being seen during the COVID-19 pandemic in South Korea
Authors: Kim Dohyung , Jung Weon , Yu Jae Yong , Chang Hansol , Lee Se Uk , Kim Taerim , Hwang Sung Yeon , Yoon Hee , Shin Tae Gun , Sim Min Seob , Jo Ik Joon , Cha Won Chul
Published: March 2022

Objective Coronavirus disease 2019 (COVID-19) has notably altered the emergency department isolation protocol, imposing stricter requirements on probable infectious disease patients that enter the department. This has caused adverse effects, such as an increased rate of leave without being seen (LWBS). This study describes the effect of fever/respiratory symptoms as the main cause of isolation regarding LWBS after the COVID-19 pandemic.Methods We retrospectively analyzed emergency department visits before (March to July 2019) and after (March to July 2020) the COVID-19 pandemic. Patients were grouped based on existing fever or respiratory symptoms, with the LWBS rate as the primary outcome. Logistic regression analysis was used to identify the risk factors of LWBS. Logistic regression was performed using interaction terminology (fever/respiratory symptom patient [FRP]×post–COVID-19) to determine the interaction between patients with FRPs and the COVID-19 pandemic period.Results A total of 60,290 patients were included (34,492 in the pre–COVID-19, and 25,298 in the post–COVID-19 group). The proportion of FRPs decreased significantly after the pandemic (P<0.001), while the LWBS rate in FRPs significantly increased from 2.8% to 19.2% (P<0.001). Both FRPs (odds ratio, 1.76; 95% confidence interval, 1.59–1.84 (P<0.001) and the COVID-19 period (odds ratio, 2.29; 95% confidence interval, 2.15–2.44; P<0.001) were significantly associated with increased LWBS. Additionally, there was a significant interaction between the incidence of LWBS in FRPs and the COVID-19 pandemic period (P<0.001).Conclusion The LWBS rate has increased in FRPs after the COVID-19 pandemic; additionally, the effect observed was disproportionate compared with that of nonfever/respiratory symptom patients.
Th1 / Th2 cytokine polarization in milk according to different pathogens causing subclinical mastitis in cows
Authors:   Kastamonu University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynecology, 37100 Elazig, Turkey mail, Safak Tarik
Published: March 2022

The aim of this study to determine the Th1/Th2 cytokine balance in milk according to the bacterial species that cause subclinical mastitis in cows. The California Mastitis Test (CMT) was applied to the selected cows. The cows were divided into four groups: cows with negative CMT (n = 45); Escherichia coli (E. coli) group included only cows with E. coli growing in CMT-positive milk samples (n = 45); Streptococcus agalactiae (S. agalactiae) group included cows with only S. agalactiae growing in CMT-positive milk samples (n = 45); Staphylococcus aureus (S. aureus) group included cows with only S. aureus growing in CMT-positive milk samples (n = 45). Somatic cell count (SCC) in fresh milk samples was measured using the DeLaval Cell Counter device. Also, cytokine analyses were performed using Species-specific commercial ELISA kits. Tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) concentrations were relatively high in the E. coli group, but the interleukin (IL)-2 concentration was low. The lowest concentration of IL-4 was found in the CMT-negative group. The highest IL-5 concentration was found in the S. agalactiae group, while the highest milk IL-10 concentration was found in the S. aureus group. Also, T helper (Th1/Th2) polarization shifted towards Th1 in milk with mastitis caused by E. coli. Th1/Th2 polarization was shifted to Th2 in milk with mastitis caused by S. aureus and S. agalactiae. Based on our findings, cellular immunity should be maintained in mastitis cases due to E. coli, and humoral immunity should be supported in mastitis caused by S. aureus and S. agalactiae.
The features of psychological adaptation of women with early menopause
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Stepanenko T.O.
Published: March 2022

Psychoemotional disorders belong to the early symptoms of climacteric syndrome, especially expressed on the background of history of depression. The objective: to investigate the features of the level of situational and personal anxiety, as well as the level of depression in women with early onset menopause. Materials and methods. 214 women were examined, 74 of them had complaints of termination of menstruation in the age group under 40 years old (Group I), 70 menopausal women at the age of 45 years (Group II) and 70 women in age 38–42 years with unbreakable menstrual function (III group). All women were offered a scale of reactive and personal anxiety, the results for each type of anxiety were evaluated in gradations: up to 30 points – low; 31–45 – average; 46 or more – high anxiety. In addition, all participants were asked to complete the Tsong scale, the result was evaluated in the range of the sum of points in gradations: 25–49 – normal, 50–59 – light depression, 60–69 – moderate depression, 70 and more – severe depression. The statistical probability of differences between groups is estimated by the Kolmogorov-Smirnov method. Results. Regardless of the age of menopause, no more than 28% of patients had a low level of situational anxiety, while this result is characteristic of more than half of women of the same age group with preserved reproductive function. A high level of personal anxiety was found among patients in Group I – 27%, which is significantly higher than in women with menopause after 45 years or with preserved reproductive function. In the group of early completion of reproductive function, 87.8% of women in the survey indicated a degree of severity of depression, in the menopause group after 45 years – only half. The absolute majority of patients in both groups had a mild depressive mood, but the frequency of severe depression was almost 6 times higher in the early menopause group. Conclusion. The findings suggest that early menopause is accompanied not only by more severe physical manifestations, such as cardiovascular damage, but also by more pronounced psychological disorders, a high level of not only situational but also personality anxiety, as well as greater prevalence of depression and severe her shape. Such data is an additional argument in favor of the need for correction of menopausal disorders in such women. Key words: early menopause, depression, situational and personality anxiety.
Modern approaches to the correction of vaginal dysbiosis in pregnant women after antibiotic therapy
Authors:   Bukovinian State Medical University, Chernivtsi, Ukraine, Kravchenko O.V.
Published: March 2022

The objective: is to evaluate the effectiveness of the use of the Floric probiotic system for the restoration of vaginal microbiocenosis after antibiotic therapy during pregnancy. Materials and methods. We examined 58 pregnant women, in the II and III trimester of gestation, who received antibacterial therapy for bacterial vaginosis, nonspecific vaginitis and cervicitis, trichomonas colpitis and vulvovaginal candidiasis. All pregnant women underwent a general clinical examination, bacterioscopic and bacteriological examination of vaginal secretions immediately after the end of antibiotic therapy, on the 7th and 14th day of observation. All patients received probiotic Florica, which was used vaginally by 1–2 suppositories for 10 days after antibacterial therapy. Results. Bacterioscopic and bacteriological examination of vaginal contents showed that antibacterial therapy leads to excessive growth of conditionally pathogenic flora and depression of symbiotic microorganisms. Lactic acid bacteria in the dynamics of treatment with probiotic Floric were detected in the increasing titer in the majority of the examined. Recovery of vaginal flora after treatment was observed in 56 (96.5%) women. The level of vaginal pH decreased to normal values (pH <4.5) in almost all women included in the examination group (94.8%). Conclusion. Antibacterial agents, regardless of group affiliation, negatively affect the state of vaginal microbiocenosis, contributing to the development of antibacterial vaginal dysbiosis. The use of the Floric probiotic system allows to bring to a qualitatively new effective level the prevention and treatment of dysbiotic disorders in pregnant women, which will certainly improve the perinatal outcomes and ensure the formation of the physiological microbiocenosis in the biotopes of the newborn. Key words: pregnancy, antibiotic therapy, dysbiosis, probiotic Florica.
Effect of gibberellin, nano-nutrition with titanium, zinc and iron on yield and some physiological and qualitative traits of white beans
Authors: AZIMI Seyed Mostafa , EISVAND Hamid Reza , ISMAILI Ahmad , AKBARI Naser
Published: March 2022

Plant nutrition has a vital role in crop production. This study was performed to investigate the effects of different application methods of some nutrients (nano Fe, Zn, and Ti), and gibberellin on yield, some morphophysiological and grain protein of white beans in 2018 as a factorial experiment in a randomized complete block design with four replications. Experimental factors included seed priming (hydropriming, gibberellin priming, titanium nano dioxide, and nano-Zn priming) and micronutrient foliar spraying (zinc, iron, and zinc + iron). The results illustrated that seed priming and foliar application significantly affected yield, yield components and chlorophyll content. Plant height increased in seed priming treatment with gibberellin and foliar application of zinc + iron by 13% compared to the control. Furthermore, this treatment enhanced the number of sub-branches per plant by 32% compared to the control. Grain yield components such as the number of pods per plant and 100-grain weight were also affected by seed priming with nano-Zn, and the simultaneous spraying of iron and zinc that grain yield by 18%, so that grain yield by 2649 kg ha–1 in hydropriming treatment reached to 3211 kg ha–1 in nano-Zn priming with simultaneous application of zinc and iron. Nano-Zn priming with iron foliar application caused the highest biological yield (9011 kg ha–1), which increased by 19% compared to control. Nano-Zn priming increased grain protein percentage by 21%. This treatment along with the foliar application of zinc + iron, significantly enhanced leaf chlorophyll content compared to other treatments. Therefore, to increase the yield of white beans, priming treatment with nano-Zn as well as foliar application of zinc + iron can be used.
Biofortification with copper nanoparticles (Nps Cu) and its effect on the physical and nutraceutical quality of hydroponic melon fruits
Authors: FORTIS HERNÁNDEZ Manuel , ORTIZ LOPEZ Jaime , PRECIADO RANGEL Pablo , TREJO VALENCIA Radames , LAGUNES FORTIZ Erika , ANDRADE-SIFUENTES Alfonso , RUEDA PUENTE Edgar O.
Published: March 2022

Currently, the use of nanoparticles is having an impact on agricultural production. There is evidence that copper nanoparticles have a strong impact on the growth and development of different crops. Biofortification specifically with (NPs Cu) improves the nutritional quality of food and its consumption has a positive influence on the health of humanity. The objective of this study consisted in evaluating the foliar application of copper nanoparticles (NPs Cu), on the weight of the fruit, nutraceutical quality and concentration of copper in melon fruit pulp. The treatments consisted of five doses of Cu NPs: 0, 1.8, 3.6, 5.4, 7.2 and 9.0 mg L -1 sprinkled foliarly. The variables evaluated were fruit weight, polar and equatorial diameter, firmness, total soluble solids, bioactive compounds and copper content in melon pulp. The results obtained indicated that the foliar application of NPs Cu, improved the physical and nutraceutical quality and the concentration of Cu in melon fruits. The highest weight and the best diameters of the fruit were obtained with the highest concentrations of NPs Cu (7.2 and 9.0 mg L-1). The concentration of 3.6 mg L-1 Cu NPs presented the highest antioxidant capacity with a value of 117,713 mg equiv. Trolox * 100 mg -1 PF, and higher content of phenols with 243.68 mg ac. gallic / 100 g FP, exceeding the concentration of 1.8 mg L -1 by 39% and the control treatment by 48%. The 3.6 and 5.4 mg L-1 treatments obtained the highest amount of flavonoids with values ​​of 149.903 and 148.29 mg QE / 100 g -1 FP, respectively. Regarding the copper concentration in the melon fruit pulp, the 9.0 mg L-1 treatment presented the highest concentration with a value of 5.39 mg kg -1 PS; The results show that, statistically, there is a correlation between the copper nanoparticles and the phytochemical variables in melon fruits. It is concluded that the use of Cu NPs can be an alternative to enrich melon fruits, and could help to solve the copper deficiency in the diet of the population.
Evaluation of water deficit tolerance in maize genotypes using biochemical, physio-morphological changes and yield traits as multivariate cluster analysis
Authors: PIPATSITEE Piyanan , TISARUM Rujira , SAMPHUMPHUANG Thapanee , KONGPUGDEE Sumaid , TAOTA Kanyaratt , EIUMNOH Apisit , CHA-UM Suriyan
Published: March 2022

Drought is an abiotic stress that inhibits plant growth and development and, therefore, declines crop productivity, as seen in maize plant. The aim of this investigation was to identify the candidate maize varieties that can be grown under water limited conditions using physio-morphological and yield attributes. Eight genotypes of maize including ‘Suwan4452’ (drought tolerant) as a positive check, ‘CP301’, ‘CP-DK888’, ‘DK7979’, ‘DK9901’, ‘Pac339’, ‘S7328’, and ‘Suwan5’ were selected as test plants. Physiological, biochemical and morphological characteristics at seedling (24 day after sowing; DAS) and reproductive (80 DAS) developmental stages of plants under 20-day water withholding (WD), and yield traits at harvesting period were analysed. Leaf temperature in each genotype increased with the degree of water deficit stress, leading to leaf chlorosis, and reduction in maximum quantum yield of PSII (Fv/Fm), photon yield of PSII (ΦPSII), net photosynthetic rate (Pn), overall growth and yield. Pn and stomatal conductance (gs) in drought tolerant genotype, ‘Suwan4452’, were decreased by 19.1% and 18.6%, respectively, whereas these in drought sensitive, ‘Pac339’, were significantly declined by 53.9% and 61.8%, respectively. Physio-morphological parameters, growth performance and yield-related traits of maize genotypes grown under water deficit conditions and well-watered conditions were subjected to Ward’s cluster method for identification of water deficit tolerant cultivars. Maintaining photosynthetic abilities, osmotic adjustment and CWSI in drought tolerant genotypes of maize were evidently demonstrated to keep overall growth performance and yield attributes. Based on multivariate cluster analysis and PCA (principal component analysis), ‘Suwan4452’, ‘CP-DK888’ and ‘S7328’ were categorized as drought tolerant genotypes whereas ‘Suwan5’, ‘Pac339’, ‘DK7979’, ‘CP301’ and ‘DK9901’ were identified as drought susceptible cultivars. Hybrid maize cvs. ‘CP-DK888’ and ‘S7328’ may further be suggested to be grown in the rainfed area without irrigation.
Floristic diversity of climbing plants in tropical forests of Similipal Biosphere Reserve, Odisha, India
Authors: ROUT Debidutta , MOHANTA Manas R. , SAHU Sudam C.
Published: March 2022

Climbers influence the diversity and composition of forest ecosystem immensely. We have investigated the floristic composition of climbing plants in tropical forests of Similipal Biosphere Reserve (SBR), Odisha, India. A total of 120 climber plant species belonging to 74 genera and 33 families were documented in all forests. Among families, the most speciose families were Fabaceae (25 species) and Convolvulaceae (22 species) followed by Cucurbitaceae (11 species), Vitaceae (8 species), Dioscoreaceae (7 species) etc. Similarly, dominant genera were Ipomoea possessing the highest number of species i.e., 9 species followed by Dioscorea (7 species), Vigna (6 species) and Cissus (4 species) etc. There was a remarkable difference noted in the structure and climbing mechanism of different climbers.  The climbing plants diversity of SBR not only contributing to the overall forest biodiversity significantly but also maintain the ecological balance of the whole ecosystem. Climbers are the major resource of economic value in and around the biosphere reserve and thus their use and sustainable management must be given principal attention.
Nursing diagnoses of newborns in rooming-in care using ICNP®
Authors: Almeida Viviane Saraiva de , Andrade Marilda , Querido Danielle Lemos , Esteves Ana Paula Vieira dos Santos , Nóbrega Maria Miriam Lima da , Christoffel Marialda Moreira , Leite Helder Camilo
Published: March 2022

ABSTRACT Objectives: to create nursing diagnosis definitions for newborns in rooming-in care, using the International Classification for Nursing Practice (ICNP). Methods: methodological study following the steps for the identification and validation of relevant terms to care for clients; cross-mapping of the terms identified with the terms of the ICNP® 2019; elaboration and validation of the nursing diagnostic definitions of ICNP® and later classification according with the Basic Human Needs described by Wanda Horta. Results: from the terms extracted, 168 were validated through specialist consensus, subsidizing the elaboration of 27 diagnosis definitions. Conclusions: the most common diagnoses for the clients studied were: “Effective Feeding Behaviour”, “Effective Urination”, “Normal Respiration Rhythm”, “Effective Swallowing”, “Effective Peripheral Intravenous Access”, and “Effective Parent Child Attachment”. It was confirmed that the records of psychobiological needs are mainly made by nurses, which were responsible for 23 of the diagnoses in this study.
Factors associated with high blood pressure and stress in men deprived of liberty
Authors: Ramos Alexandre Inácio , Sinski Kassiano Carlos , Palombit Mateus Rodrigo , Cruz Ediani da , Pitilin Erica de Brito , Léo Marcela Martins Furlan de , Araújo Jeferson Santos , Conceição Vander Monteiro da
Published: March 2022

ABSTRACT Objectives: to identify and classify blood pressure and self-reported stress in inmates and investigate the association of these events with clinical and sociodemographic data. Methods: a cross-sectional and quantitative study with 240 inmates. A sociodemographic questionnaire, Lipp’s Inventory of Stress Symptoms for Adults, blood pressure classification, waist circumference and Body Mass Index were used. Results: mean age of 37.17 years (SD 11.5), 48.8% (n=117) single, 42.9% (n= 103) brown. The majority 67.9% (n=163) had been incarcerated for less than 4 years and 33.8% (n=81) were hypertensive. Blood pressure was compatible with the general population. Smoking, consumption of antihypertensive and hypoglycemic medications, concern about salt consumption, and a family history of hypertension were associated with self-perceived stress (resistance and exhaustion). Conclusions: the group is exposed to modifiable risk factors, especially stress, which favor hypertension and lack preventive strategies and access to health.
Zebrafish (Danio rerio) meets bioethics: the 10Rs ethical principles in research
Authors: Canedo Aryelle , Saiki Patrícia , Santos Andressa Liberal , Carneiro Karla da Silva , Souza Andreza Martins de , Qualhato Gabriel , Brito Rafaella da Silva , Mello-Andrade Francyelli , Rocha Thiago Lopes
Published: March 2022

Abstract Zebrafish (Danio rerio) is a tropical fish species widely used in research, worldwide. The development of genetically modified animals and the increasing number of zebrafish breeding facilities due to their emerging use in several research fields, opened room for new ethical challenges for research carried out with this species. It is necessary to raise the scientific community’s awareness of the ethical standards and laws in force, on animal research. Thus, the aim of the current study is to describe 10 Rs ethical principles by using zebrafish as model system in research. The classical 3 Rs concerning animal welfare, namely replacement, reduction and refinement; and the added 7 Rs related to scientific (registration, reporting, robustness, reproducibility and relevance) and conduct principles (responsibility, and respect) in zebrafish research are herein presented and critically discussed. The use of these 10 Rs by researchers, institutions and the Animal Ethics Committee is recommended to support regulations, decision-making about and the promotion of zebrafish health and welfare in research.
Curriculum integration in the formative assessment of distance continuing medical education: the use of integrative activities
Authors: Wander Brenda , Fernandes Alessandra Tavares Francisco , Daudt Carmen Vera Giacobbo , Gomes Marta Quintanilha , Pinto Maria Eugênia Bresolin
Published: March 2022

Abstract Introduction: The article describes the development and implementation of integrative activities as a formative evaluation of a distance-learning course of preceptorship specialization in Family and Community Medicine and discusses how the use of this activity is capable of integrating and assessing different knowledges, practices and performance of students in this modality of education. The course curriculum involves units with modules in three areas: family and community medicine, preceptorship and clinical practice, allowing the approach of essential topics for the practice of the specialty preceptor, which go beyond the study of pedagogical aspects. Experience report: The student was encouraged to carry out a textual production based on contextualized problems in the Primary Health Care preceptorship, guided by the tutor, aiming to critically reflect on the contents of each teaching unit. Illustrated situations were used in the activity statement, shown in comic strip format, which qualified the interpretation of the context addressed in the activity and promoted greater approximation with the reality experienced by the student. The contextualization of the activity and the exercise of putting oneself in the preceptor’s place were considered positive points by the tutors. Discussion: The student-tutor interaction is a fundamental part of the activity, as it allows the construction of knowledge from an interactionist perspective of education, which is the basis of the pedagogical proposal of the course. The activity allowed the identification of gaps and potentialities in the students’ learning and the implementation of particular pedagogical interventions. Conclusions: This type of activity ensures important dimensions of evaluative work in long-term courses: the procedural and interdisciplinary features. The integrative activity model can be used in distance courses with different disciplines, aiming at integrating them, providing a more in-depth approach and bringing the educational contents closer to the student’s reality.
PrevTev: construção e validação de aplicativo móvel para orientações sobre tromboembolismo venoso
Authors: Toledo Thaís Ramos de Oliveira , Peres Ângela Lima , Barros Pedro Edson Lima , Russo Rafaela Costa , Carvalho Lúcyo Wagner Torres de
Published: March 2022

Resumo: Introdução: Como o tromboembolismo venoso (TEV) é uma das principais causas de mortes evitáveis em pacientes hospitalizados, é importante a criação de medidas para sua prevenção e seu tratamento. Porém, para a profilaxia de qualidade, a educação e o envolvimento dos pacientes são necessários, e uma das ferramentas para facilitar as atividades educativas em saúde são as tecnologias educacionais. Objetivo: Este estudo teve como objetivos construir e validar um aplicativo móvel sobre orientações para prevenção de TEV em pacientes hospitalizados durante a internação e após a alta hospitalar. Método: Trata-se de um estudo metodológico composto por duas fases (construção e validação), divididas em nove etapas. A fase de validação foi realizada com 11 juízes especialistas e 30 representantes do público-alvo. Utilizaram-se quatro instrumentos de coletas de dados: Suitability Assessment of Materials (SAM), Instrumento de Validação de Conteúdo Educativo em Saúde (IVCES), Instrumento de Avaliação para o Público-alvo e System Usability Scale (SUS), todos interpretados mediante avaliação específica. Resultado: Entre os juízes especialistas, a média da pontuação do SAM foi 89,4%, e a do IVCES, 93,8%. Em relação à opinião do público-alvo, a média de concordância no primeiro instrumento de coleta de dados foi 95%, e a do SUS, 79,5 pontos. Conclusão: O aplicativo móvel foi considerado válido mediante a metodologia aplicada por juízes especialistas e público-alvo.
La médiation entre français et langues de la migration en France
Authors: LECONTE Fabienne
Published: March 2022

Les pratiques d’interprétation-médiation à destination des migrants représentent une situation particulière de médiation entre langues et cultures. Dans cette contribution, on retrace dans un premier temps les premières expériences d’interprétation médiation mises en place dans les années quatre-vingt par des personnes appartenant aux groupes culturels concernés. Celles-ci sont analysées avec le regard rétrospectif qu’un portent les acteurs. Dans un second temps, on rendra compte d’une recherche menée par entretiens en 2017 auprès de personnes pratiquant l’interprétation-médiation en mileu social. Les prestations sont fournies entre institutions et personnes migrantes ne maitrisant ni la langue ni les codes culturels. On confrontera alors ce que les interprètes-médiateurs disent de leurs pratiques, leurs ressentis en fonction des places qu’ils occupent et de leur expérience et quelques définitions circulantes de la médiation dans des champs disciplinaires pluriels (droit, sociologie, économie, sciences du langage, didactique des langues). Le terme médiation est en effet souvent entendu mais plus rarement défini.
Traduction littéraire en audiovisuel
Authors: PURI Asha
Published: March 2022

La communication souligne les spécificités de la traduction littéraire en audiovisuel et met l’accent sur une méthodologie de sous-titrage d’un texte littéraire adapté à l’écran. Il s’agit d’une expérience fondée sur un enseignement de niveau masters et de doctorat, Théorie et pratique de traduction et de sous-titrage de cinéma littéraire, dispensé au premier semestre 2017 suivi d’un atelier pratique de traduction et de sous-titrage lancé au second semestre 2017 destiné au même groupe. Il vise au développement des capacités linguistiques et métalinguistiques/culturelles des étudiants. Le cours Théorie et pratique de traduction et de sous-titrage de cinéma littéraire s’est fait en collaboration avec un autre cours de même niveau intitulé Histoire de traductions littéraires et d’adaptations de la littérature à l’audiovisuel. Le déroulement de l’atelier et les questions qui s’en dégagent y figurent. En vue de mettre en place une méthodologie capable de résoudre d’une manière pragmatique les problèmes de la traduction littéraire à l’audiovisuel ainsi que la traduction interlinguistique des sous-titres, fondée sur une approche participative et comparatiste, une étude en groupe du texte littéraire, son adaptation pour l’écran, des traductions des sous-titres déjà disponibles et des adaptations audiovisuelles dans d’autres langues sont autant de documents dont on s’est servi.
Oxidation of Lignin-Carbohydrate Complex by Laccase/Co(salen) One-Pot Catalysis
Authors: Zhou Xue-Fei
Published: March 2022

Lignin-carbohydrate complex (LCC) is hybrid structures containing covalently linked moieties of lignin and carbohydrates. The nature and amount of LCC affect both industrial processes and practical applications of lignocellulosic biomass. Herein, the LCC was isolated from bamboo by successive solvent extraction and precipitation. The effects and mechanism of LCC oxidation respectively by laccase, Co(salen), and laccase/Co(salen) in the presence of molecular oxygen have been investigated by composition analysis using the standard of National Renewable Energy Laboratory (NREL) and high-performance anion exchange chromatography (HPAEC), GPC, FTIR, and 2D-HSQC NMR. We can conclude that the laccase/Co(salen) one-pot catalysis modified the LCC in such a way that more carbohydrate was removed from the LCC with lower molecular weight of LCC as shown by GPC; the catalytic treatments produced oxidation at lignin side-chains and cleavage of lignin β-O-4', β-β' and β-5' bonds in LCC, and cleavage of benzyl-sugar ether, phenyl glycoside and γ-ester bonds in LCC, as shown by FTIR and 2D-HSQC NMR, especially after the laccase/Co(salen) one-pot treatment. The further insight of LCC degradation was discussed in light of the results obtained in oxidation of the LCC model compound coniferin.
Malaysian Tualang Honey Suppresses the Angiogenic Events in Endothelial Cells Induced by Vascular Endothelial Growth Factor
Authors: Abdul Khalid Ahmad Firdaus Bin , Chin Theng Ng , Lai Yen Fong , Tan Jun Jie , Yakop Fahmi Bin , Kamaruddin Nur Aqilah Binti , Abdullah Muhammad Nazrul Hakim , Yong Yoke Keong
Published: March 2022

Anti-VEGF therapy has been used as the anti-angiogenic agent in cancer treatment. However, the treatment often couples with severe complications. Complementary natural products that offer similar anti-angiogenic potency with less side effects are sought as alternatives. Study showed that Malaysian Tualang Honey (MTH) can inhibit inflammation-induced vascular hyperpermeability in vitro and in vivo, but the effect on the angiogenesis process remains unclear. Thus, this study aims to determine the anti-angiogenic effects of MTH. Effects of MTH ranging from 0.3% to 0.9% on VEGF-induced human umbilical vein endothelial cells (HUVEC) angiogenesis was determined by proliferation, migration and tube-formation assays. Matrix metalloproteinase-2 (MMP-2) secretion from HUVEC and VEGF production from MCF7 cancer cells in response to MTH were also quantified by using ELISA kits. Suramin, an angio-suppressive agent was used as positive control. MTH significantly suppressed HUVEC proliferation (from 155% proliferation rate to 54%); migration (~ 50% inhibition rate) and tube-formation (69% reduction) induced by VEGF. These findings were explained by the significant reduction (p < 0.05) of VEGF-induced MMP-2 secretion in HUVEC with 39% suppression exhibited by 0.9% of MTH. MTH also significantly (p < 0.05) reduced VEGF secretion (19% reduction compared to control) in MCF7 breast cancer cells. Our findings suggest that the anti-angiogenic effects of MTH mainly targets endothelial cell through inhibition cell proliferation, migration and tube formation capacity, via suppression of MMP-2 secretion by the endothelial cells. However, MTH has less prominent effect on suppressing VEGF secretion by the MCF7 cancer cells.
Antibiotic Resistance Patterns of Coagulase-Negative Staphylococcus (CoNS) Isolates from a Major Teaching Hospital in Kuala Lumpur, Malaysia
Authors: Sukri Asif , Mohamad Zaki Haifa Hanani , Mohamad Zin Noraziah
Published: March 2022

Coagulase-negative Staphylococcus (CoNS) species is a leading cause of nosocomial infection in patients with indwelling medical devices and immunocompromised patients. This study was conducted to determine the antibiotic resistance pattern of CoNS isolated from a major teaching hospital in Malaysia. A total of 43 CoNS isolates were collected from August to October 2018 at Hospital Canselor Tuanku Muhriz, Kuala Lumpur, Malaysia. Speciation of CoNS species was conducted by 16S rRNA sequencing. Antibiotic susceptibility test was performed using a standard procedure, and detection of staphylococcal cassette chromosome mec (SCCmec) elements and antibiotic resistance genes were conducted via multiplex polymerase chain reaction (PCR). Comparison of 16S rRNA sequences showed that 67.44% of the isolates were identified as S. epidermidis, followed by S. haemolyticus (11.63%), S. hominis (9.3%), S. capitis (4.65%), and other Staphylococcus sp. (6.98%). All the CoNS isolates were susceptible to linezolid and tedizolid, while most of them were resistant towards penicillin (86.05%), cefoxitin (69.77%), erythromycin (72.02%), and 88.37% of them were resistant to at least 3 antibiotics. The majority of CoNS harboured nontypeable SCCmec elements. AacA-D (95.5%) and ermC (78.6%) were the most commonly detected antibiotic resistance genes while no detection of tetK, tetM and ermA genes were observed. This study showed a high prevalence of multidrug-resistant CoNS in HCTM healthcare settings. Understanding CoNS resistance mechanism is warranted for intervention strategy.