bluuebunny/crossref_metadata_2025 huggingface dataset:
Taxonomic myths and phylogenetic realities in the systematics of the Opisthorchiidae (Trematoda)
Authors: Sokolov Sergey , Kalmykov Alexandr , Frolov Evgeniy , Atopkin Dmitry
Published: November 2021

The Opisthorchiidae are a large trematode group with a complex taxonomic structure at the subfamily level. Phylogenetic assessment of the Metorchiinae, the Opisthorchiinae and the Pseudamphistominae was carried out using 28S rDNA, concatenated 18S + 28S rDNA, ITS1 and ITS2 rDNA, and COI mt DNA sequences data set. Phylogenetic analyses showed that Metorchis (Metorchiinae), Pseudamphistomum (Pseudamphistominae), Opisthorchis and Clonorchis (Opisthorchiinae) were grouped in a same clade and that Amphimerus (Opisthorchiinae) has a basal position to all these genera. Thus, the Opisthorchiinae can only be resolved as a monophyletic taxon in combination with metorchiine and pseudamphistomine trematodes. The group comprising opisthorchiines, metorchiines and pseudamphistomines clustered with apophallines and liliatrematines. However, the Apophallinae did not appear as a monophyletic taxon. As a result, two subfamilies of traditional opisthorchiids, the Metorchiinae and the Pseudamphistominae, were not recognized as valid. In addition, we demonstrated the existence of three monophyletic groups of heterophyid trematodes, which is important for the future revision of this group.
Structural basis for sarcolipin’s regulation of muscle thermogenesis by the sarcoplasmic reticulum Ca
2+
-ATPase
Authors: Wang Songlin , Gopinath Tata , Larsen Erik K. , Weber Daniel K. , Walker Caitlin , Uddigiri Venkateswara Reddy , Mote Kaustubh R. , Sahoo Sanjaya K. , Periasamy Muthu , Veglia Gianluigi
Published: November 2021

A small peptide regulates muscle thermogenesis through interaction with the sarcoplasmic reticulum calcium ATPase.
Implantable system for chronotherapy
Authors: Lee Seung Ho , Wan Qianqian , Wentworth Adam , Ballinger Ian , Ishida Keiko , Collins Joy E. , Tamang Siddartha , Huang Hen-Wei , Li Canchen , Hess Kaitlyn , Lopes Aaron , Kirtane Ameya R. , Lee Jung Seung , Lee SeJun , Chen Wei , Wong Kaitlyn , Selsing George , Kim Hyunjoon , Buckley Stephen T. , Hayward Alison , Langer Robert , Traverso Giovanni
Published: November 2021

A mobile app–controlled implantable system enables chronotherapy by controlling the timing of drug administration.
The contribution of low contrast–preferring neurons to information representation in the primary visual cortex after learning
Authors: Kimura Rie , Yoshimura Yumiko
Published: November 2021

Low-contrast preference in V1 activity increased after learning and may be involved in low-contrast visual discrimination.
Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
Authors: Zafferani Martina , Haddad Christina , Luo Le , Davila-Calderon Jesse , Chiu Liang-Yuan , Mugisha Christian Shema , Monaghan Adeline G. , Kennedy Andrew A. , Yesselman Joseph D. , Gifford Robert J. , Tai Andrew W. , Kutluay Sebla B. , Li Mei-Ling , Brewer Gary , Tolbert Blanton S. , Hargrove Amanda E.
Published: November 2021

Small-molecule targeting of RNA stem loops in 5′-end of SARS-CoV-2 reveals novel RNA targets for viral inhibition.
Loss-of-function mutation in
IKZF2
leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
Authors: Hetemäki Iivo , Kaustio Meri , Kinnunen Matias , Heikkilä Nelli , Keskitalo Salla , Nowlan Kirsten , Miettinen Simo , Sarkkinen Joona , Glumoff Virpi , Andersson Noora , Kettunen Kaisa , Vanhanen Reetta , Nurmi Katariina , Eklund Kari K. , Dunkel Johannes , Mäyränpää Mikko I. , Schlums Heinrich , Arstila T. Petteri , Kisand Kai , Bryceson Yenan T. , Peterson Pärt , Otava Ulla , Syrjänen Jaana , Saarela Janna , Varjosalo Markku , Kekäläinen Eliisa
Published: November 2021

A truncated variant of Helios causes a human immunodeficiency disease with signs of immune overactivation.
Is early activity resumption after paediatric concussion safe and does it reduce symptom burden at 2 weeks post injury? The Pediatric Concussion Assessment of Rest and Exertion (PedCARE) multicentre randomised clinical trial
Authors: Ledoux Andrée-Anne , Barrowman Nick , Bijelić Vid , Borghese Michael M , Davis Adrienne , Reid Sarah , Sangha Gurinder , Yeates Keith Owen , Tremblay Mark S , McGahern Candice , Belanger Kevin , Barnes Joel D , Farion Ken J , DeMatteo Carol A , Reed Nick , Zemek Roger
Published: November 2021

Objective

Investigate whether resuming physical activity (PA) at 72 hours post concussion is safe and reduces symptoms at 2 weeks, compared with resting until asymptomatic.

Methods

Real-life conditions, multicentre, single-blinded randomised clinical trial, conducted in three Canadian paediatric emergency departments (ED). Children/youth aged 10–<18 years with acute concussion were recruited between March 2017 and December 2019, and randomly assigned to a 4-week stepwise return-to-PA protocol at 72 hours post concussion even if symptomatic (experimental group (EG)) or to a return-to-PA once asymptomatic protocol (control group (CG)). The primary outcome was self-reported symptoms at 2 weeks using the Health and Behaviour Inventory. Adherence was measured using accelerometers worn 24 hours/day for 14 days post injury. Adverse events (AE) (worsening of symptoms requiring unscheduled ED or primary care visit) were monitored. Multivariable intention-to-treat (ITT) and per-protocol analyses adjusting for prognostically important covariates were examined. Missing data were imputed for the ITT analysis.

Results

456 randomised participants (EG: N=227; mean (SD) age=13.3 (2.1) years; 44.5% women; CG: N=229; mean (SD) age=13.3 (2.2) years; 43.7% women) were analysed. No AE were identified. ITT analysis showed no strong evidence of a group difference at 2 weeks (adjusted mean difference=−1.3 (95% CI:−3.6 to 1.1)). In adherent participants, initiating PA 72 hours post injury significantly reduced symptoms 2 weeks post injury, compared with rest (adjusted mean difference=−4.3 (95% CI:−8.4 to –0.2)).

Conclusion

Symptoms at 2 weeks did not differ significantly between children/youth randomised to initiate PA 72 hours post injury versus resting until asymptomatic; however, many were non-adherent to the intervention. Among adherent participants, early PA was associated with reduced symptoms at 2 weeks. Resumption of PA is safe and may be associated with milder symptoms at 2 weeks.

Level of evidence

1b.

Trial registration number

NCT02893969.

Registry name

Pediatric Concussion Assessment of Rest and Exertion (PedCARE).
Independent and combined associations between multiple lifestyle behaviours and academic grades of inner urban and peri-urban high school students: a cross-sectional study in Chongqing, China
Authors: Cai Zhengjie , Xian Jinli , Araujo Camila , Zhang Ziwei , Zhou Hongyu , Peng Huan , Sharma Manoj , Zhao Yong
Published: November 2021

Objectives

This study aims to assess the independent and combined associations between multiple lifestyle behaviours and academic grades of inner urban high school students (IUHSSs) and peri-urban high school students (PUHSSs).

Design

A cross-sectional study was conducted.

Participants

There are 1481 high school students (49.9% boys) in this study, who were enrolled from one inner urban and two peri-urban schools in Chongqing, China.

Outcome measures

Academic grades were assessed based on the students’ self-reported grade ranking in the last cumulative examination.

Results

In IUHSSs and PUHSSs, high frequency of sugar-sweetened beverage consumption was unlikely to obtain high academic grades (OR 0.56, 95% CI 0.32 to 0.99 and 0.63, 95% CI 0.42 to 0.96), respectively). Among IUHSSs, meeting the recommendations for weekday screen time and egg consumption (OR 1.57, 95% CI 1.06 to 2.34 and 1.60, 95% CI 1.04 to 2.47, respectively) and high frequency of fruit consumption (1.67, 95% CI 1.11 to 2.50) were significantly associated with high academic grades; meeting the recommendation for weekday sleep duration was unlikely to obtain high academic grades (0.46, 95% CI 0.21 to 0.98). Among PUHSSs, meeting the recommendations for weekend sleep duration (1.40, 95% CI 1.02 to 1.93) and eating dinner regularly (1.55, 95% CI 1.01 to 2.37) had significant associations with high academic grades. No significant associations were found between physical activity and academic grades in both IUHSSs and PUHSSs (p>0.05). Moreover, IUHSSs with 9–13 healthy lifestyle behaviours were 3.25 times more likely to achieve high academic grades than IUHSSs with 1–6 healthy lifestyle behaviours (3.25, 95% CI 1.96 to 5.40). No significant associations were found in the combined associations between multiple lifestyle behaviours and academic grades among PUHSSs (p>0.05).

Conclusions

Correlations were observed between lifestyle behaviours and academic grades among high school students, and cumulative associations between multiple healthy lifestyle behaviours and academic outcomes appear to be stronger than the independent associations. These findings are particularly applicable to IUHSSs.
Inflammatory bowel disease negatively impacts household and family life
Authors: Paulides Emma , Cornelissen Demi , de Vries Annemarie C , van der Woude C Janneke
Published: November 2021

Background

Inflammatory bowel disease (IBD) has a major impact on different aspects of life of patients with IBD, but functioning in the home environment is under-reported in literature. The aim of this study was to assess the impact of IBD on household and/or family life.

Method

Adult patients with IBD from the outpatient clinic of the Erasmus MC (Rotterdam, the Netherlands) were invited to participate in this cross-sectional study between September and December 2020. A questionnaire was composed to measure the impact of IBD on functioning in the household and family life. In addition, the IBD Disability Index and Work Productivity and Activity Impairment Questionnaire were used. Data were analysed using descriptive statistics and multiple logistic regression modelling.

Results

Of 308 invited patients, 229 patients were included (response rate 74%). Sixty-eight per cent of patients were diagnosed with Crohn’s disease, 69% were female and median age was 38.0 years. Many patients reported difficulties with domestic activities (55.0%), leisure (53.9%), parenting (50.6%), sexual activities (48.4%) and interpersonal relationships (39.1%). Fatigue was associated with the experience of more severe difficulties in domestic activities (OR 16.160, 95% CI 6.053 to 43.141). Furthermore, 32.7% of patients felt that IBD influenced their desire to have children.

Conclusion

IBD has a markedly negative impact on household and/or family life in many patients. To optimise patient care, household and family related difficulties need to be considered in a holistic treatment approach.
Neutron-mirror neutron mixing and neutron stars
Authors: Berezhiani Zurab , Biondi Riccardo , Mannarelli Massimo , Tonelli Francesco
Published: November 2021

The oscillation of neutron n into mirror neutron $$n'$$

n
′

, its mass degenerate partner from dark mirror sector, can gradually transform the neutron stars into the mixed stars consisting in part of mirror dark matter. In quark stars $$n-n'$$

n
-

n
′

transitions are suppressed. We study the structure of mixed stars and derive the mass-radius scaling relations between the configurations of purely neutron star and maximally mixed star (MMS) containing equal amounts of ordinary and mirror components. In particular, we show that the MMS masses can be at most $$M^{\mathrm{max}}_{NS}/\sqrt{2}$$

M

NS

max

/

2

, where $$M^\mathrm{max}_{NS}$$

M

NS

max

is a maximum mass of a pure neutron star allowed by a given equation of state. We evaluate $$n-n'$$

n
-

n
′

transition rate in neutron stars, and show that various astrophysical limits on pulsar properties exclude the transition times in a wide range $$10^{5}\,\text {year}< \tau _\varepsilon < 10^{15}\,\text {year}$$

10
5

year
<

τ
ε

<

10
15

year

. For short transition times, $$\tau _\varepsilon < 10^5$$

τ
ε

<

10
5

 year, the different mixed stars of the same mass can have different radii, depending on their age, which possibility can be tested by the NICER measurements. We also discuss subtleties related with the possible existence of mixed quark stars, and possible implications for the gravitational waves from the neutron star mergers and associated electromagnetic signals.
Mechanical properties of cured epoxy resin
Authors: Savotchenko Sergey , Kovaleva Ekaterina
Published: November 2021

We study experimentally the influence of mass fraction of L-20 hardener cold cure on mechanical properties of epoxy diane resin ED-20. We measure the hardness, tensile strength, bending strength and impact strength of resin at different values of the hardener mass fraction. It is found that the ratio hardener mass fraction of 1:0.9 leads to the highest values of the hardness, tensile strength, compressive strength and bending strength. The impact viscosity is maximum at the ratio hardener mass fraction of 1:0.8. The optimal ratio of a non-toxic safe hardener to the resin is derived based on obtained mechanical characteristics.
A Garbage Detection and Classification Method Based on Visual Scene Understanding in the Home Environment
Authors: Wu Yuezhong , Shen Xuehao , Liu Qiang , Xiao Falong , Li Changyun
Published: November 2021

Garbage classification is a social issue related to people’s livelihood and sustainable development, so letting service robots autonomously perform intelligent garbage classification has important research significance. Aiming at the problems of complex systems with data source and cloud service center data transmission delay and untimely response, at the same time, in order to realize the perception, storage, and analysis of massive multisource heterogeneous data, a garbage detection and classification method based on visual scene understanding is proposed. This method uses knowledge graphs to store and model items in the scene in the form of images, videos, texts, and other multimodal forms. The ESA attention mechanism is added to the backbone network part of the YOLOv5 network, aiming to improve the feature extraction ability of the network, combining with the built multimodal knowledge graph to form the YOLOv5‐Attention‐KG model, and deploying it to the service robot to perform real‐time perception on the items in the scene. Finally, collaborative training is carried out on the cloud server side and deployed to the edge device side to reason and analyze the data in real time. The test results show that, compared with the original YOLOv5 model, the detection and classification accuracy of the proposed model is higher, and the real‐time performance can also meet the actual use requirements. The model proposed in this paper can realize the intelligent decision‐making of garbage classification for big data in the scene in a complex system and has certain conditions for promotion and landing.
Tangnaikang Alleviates Hyperglycemia and Improves Gut Microbiota in Diabetic Mice
Authors: Zhang Liping , Wang Fen , He Hualiang , Jiao Tingting , Wu Lili
Published: November 2021

Dysregulation of gut microbiota contributes to the development of type 2 diabetes. To investigate the antidiabetic effect of Tangnaikang and its regulation of gut microbiota in diabetic KKAy mice, a type 2 diabetes mouse model was established by feeding KKAy mice with a high-fat diet (HFD) for 2 weeks. The diabetic KKAy mice were treated with vehicle, Acarbose, or different doses of Tangnaikang once a day for 8 weeks. The fasting plasma glucose (FPG) levels and bodyweights were measured weekly. The fecal and blood samples were collected 8 weeks after treatment. The 16s rRNA sequencing and bioinformatics analysis were conducted to explore the effects of Tangnaikang treatment on the richness, diversity, and relative abundance of gut microbiota. Compared with other treatments, high-dose Tangnaikang (4.68 g/kg) significantly reduced FPG levels while elevating bodyweights in model mice. Compared with saline treatment, different doses of Tangnaikang significantly increased gut microbial species richness and diversity. Linear discriminant analysis effect size identified potential bacterial biomarkers associated with Tangnaikang treatment. Relative abundance analysis revealed that Tangnaikang treatment modulated the abundance of gut bacteria at the class and genus levels, such as Bacilli, Lactobacillus, and Alistipes. The principal component analysis demonstrated that, compared with the samples of the high-dose group, the samples of medium-dose and low-dose groups were closer to those of the model group. Tangnaikang alleviated hyperglycemia and improved the composition and abundance of gut microbiota in diabetic KKAy mice.
Correlation of Dopaminergic Denervation and the Progression of Autonomic Dysfunctions in Different Clinical Subtypes of Parkinson’s Disease
Authors: Jeong Eun Hye , Sunwoo Mun Kyung , Hyung Sung Wook , Han Sun-Ku , Lee Jae Yong
Published: November 2021

Background. Autonomic dysfunctions occur in the early stage of Parkinson’s disease (PD) and impact the quality of life during the progression of the disease. In this study, we evaluated the serial progression of autonomic dysfunctions between different subtypes of a prospective PD cohort. Materials and Methods. From the Parkinson’s Progression Markers Initiative (PPMI) database, 325 PD patients (age: 61.2 ± 9.7, M : F = 215 : 110) were enrolled. Patients were subgrouped into tremor-dominant (TD), indeterminate, and postural instability and gait disorder (PIGD) subtypes. The progression of autonomic dysfunctions and dopaminergic denervation from I-123 FP-CIT SPECT images of each group were analyzed and compared at baseline, 12 months, 24 months, and 48 months of follow-up periods. Results. The SCOPA-AUT score of the indeterminate subtype was significantly higher than that of the TD subtype (

P
<
0.05

) at baseline and was significantly higher than that of both TD and PIGD subtypes (

P
<
0.05

) at 48 months. The indeterminate subtype had the most significant correlation between the aggravation of dopaminergic denervation in I-123 FP-CIT SPECT images and the increase of SCOPA-AUT scores during 48 months of follow-up (r = 0.56,

P
<
0.01

). Conclusions. Autonomic dysfunctions were most severe in the indeterminate subtype throughout the 48 months of the follow-up period, with a significant correlation with dopaminergic denervation. We suggest a positive relationship between dopaminergic denervation and autonomic dysfunctions of the indeterminate subtype, beginning from the early stage of PD.
Pilot Study of Blood Perfusion Changes at PC4 and Its Surrounding Points Induced by Acupuncture and Moxibustion
Authors: Jia Shuyong , Wang Qizhen , Li Hongyan , Song Xiaojing , Wang Shuyong , Zhang Weibo , Wang Guangjun
Published: November 2021

Acupuncture and moxibustion are widely used in clinical practice; however, the differences between their mechanisms are unclear. In the present study, the response of blood perfusion resulting from acupuncture or moxibustion at Ximen (PC4) and its surrounding points was explored. Using the wavelet method, the differences in the frequency interval of blood flux were observed. Furthermore, the correlations between these points were analyzed. The results suggested that moxibustion could significantly improve blood flow perfusion at PC4 compared to acupuncture; however, there was no significant difference around PC4. The response of blood flux at PC4 to different stimulations was related to the frequency V (0.4–1.6 Hz) component. However, a difference in response at other points was not observed. Correlation analysis showed that both acupuncture and moxibustion could cause a decline in the correlation of blood flux signals at these recorded points, but there was no significant difference between these techniques. The results suggested that, at least in the forearm, the acupuncture or moxibustion only influenced the level of blood perfusion locally.
How Technological Innovation Affect China’s Pharmaceutical Smart Manufacturing Industrial Upgrading
Authors: Wang Su , Chen Yuwen
Published: November 2021

In recent years, a new generation of information technology has provided sufficient technical support for the smart manufacturing industry. In order to promote the upgrading of China’s pharmaceutical smart manufacturing industry, the direction of industrial upgrading and transformation will be discussed from the perspective of technological innovation. According to the input and output data of technological innovation in China’s pharmaceutical manufacturing industry from 2007 to 2019, the DEA method is used to analyze the allocation of innovative resources in China’s pharmaceutical manufacturing industry in recent years. The study found that the efficiency of technological innovation in China’s pharmaceutical manufacturing industry fluctuated greatly from 2007 to 2019, with a low overall level and varying degrees of wasted resources. On this basis, an in-depth analysis of the system architecture of the pharmaceutical smart manufacturing industry under the Industry 4.0 environment was performed. Finally, four paths for the digital transformation of China’s pharmaceutical manufacturing industry are proposed. Chinese pharmaceutical manufacturing companies need to use new technologies to carry out comprehensive intelligent upgrading and digital transformation to improve innovation efficiency.
The Identification of Key Genes and Biological Pathways in Heart Failure by Integrated Bioinformatics Analysis
Authors: Yang Qianhong , Bai Xiaolu , Li Xiang , Hu Wei
Published: November 2021

Purpose. Heart failure (HF) is a clinical syndrome caused by ventricular insufficiency. In order to further explore the biomarkers related to HF, we apply the high-throughput database. Materials and Methods. The GSE21610 was applied for the differentially expressed gene (DEG) analysis. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was performed to assess Gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The Gene Set Enrichment Analysis (GSEA) was used for gene expression profile GSE21610. The Protein-Protein Interaction (PPI) network and modules were also constructed for research. These hub gene function pathways were estimated in HF progression. Result. We have identified 434 DEGs in total, including 304 downregulated DEGs and 130 upregulated DEGs. GO and KEGG illustrated that DEGs in HF were significantly enriched in G protein-coupled receptor binding, peroxisome, and cAMP signaling pathway. GSEA results showed gene set GSE21610 was gathered in lipid digestion, defense response to fungus, and intestinal lipid absorption. Finally, through analyzing the PPI network, we screened hub genes CDH1, TFRC, CCL2, BUB1B, and CD19 by the Cytoscape software. Conclusion. This study uses a series of bioinformatics technologies to obtain hug genes and key pathways related to HF. These analysis results provide us with new ideas for finding biomarkers and treatment methods for HF.
Evaluation of the Development of Fintech-Served Real Economy Based on Fintech Improvement
Authors: Zhou Mingxiang , Zheng Xiaoyan
Published: November 2021

The new generation of information technology (IT) promotes the integration of fintech with the real economy. Existing studies emphasize the relationship between fintech and the real economy over the development level of fintech-served real economy (FtRE). To fill up the gap, this paper explores the evaluation of FtRE based on fintech improvement (FtI). Firstly, an evaluation index system (EIS) was established for fintech service efficiency (FtSE), and FtSE was measured through data envelopment analysis (DEA). Then, fuzzy c-means (FCM) clustering was performed to discretize continuous indices. Drawing on matter-element theories, the authors created the classic domain and node domain of FtRE, as well as the evaluation objects of real economy, calculated the correlation between each factor affecting development level and evaluated development level, and computed the weight coefficient of each index. Finally, the influence of FtI-based FtRE development was empirically analyzed through experiments.
RRM2 Improves Cardiomyocyte Proliferation after Myocardial Ischemia Reperfusion Injury through the Hippo-YAP Pathway
Authors: Yu Huamin , Tang Haiyan , Deng Chaochao , Lin Qing , Yu Peng , Chen Shaowen , Ruan Jingming
Published: November 2021

Objective. Ribonucleotide reductase M2 (RRM2) as an enzyme that catalyzes the deoxyreduction of nucleosides to deoxyribonucleoside triphosphate (dNTP) has been extensively studied, and it plays a crucial role in regulating cell proliferation. However, its role in ischemia-reperfusion injury (I/RI) is still unclear. Methods. SD rats were used as the research object to detect the expression of RRM2 in the myocardium by constructing an I/RI model. At the same time, primary SD neonatal rat cardiomyocytes were extracted, and hypoxia/reoxygenation (H/R) treatment simulated the I/RI model. Using transfection technology to overexpress RRM2 in cardiomyocytes, quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) was used to detect the expression of RRM2, Cell Counting Kit-8 (CCK-8) assay was used to detect cell viability, and immunofluorescence staining was used to detect Ki67 and EdU-positive cells. Western blot (WB) technology was used to detect YAP and its phosphorylation expression. Results. qRT-PCR results indicated that the expression of RRM2 was inhibited in the model group, and cardiomyocytes overexpressing RRM2 can obviously promote the proliferation of primary cardiomyocytes and improve the damage of cardiac structure and function caused by I/R. At the same time, RRM2 can promote the increase of YAP protein expression and the increase of Cyclin D1 mRNA expression. Conclusion. RRM2 expression was downregulated in myocardial tissue with I/R. After overexpression of RRM2, cardiomyocyte proliferation was upregulated and the Hippo-YAP signaling pathway was activated.
Diagnostic Value of Deep Learning-Based CT Feature for Severe Pulmonary Infection
Authors: Huang Tinglong , Zheng Xuelan , He Lisui , Chen Zhiliang
Published: November 2021

The study aimed to explore the diagnostic value of computed tomography (CT) images based on cavity convolution U-Net algorithm for patients with severe pulmonary infection. A new lung CT image segmentation algorithm (U-Net+ deep convolution (DC)) was proposed based on U-Net network and compared with convolutional neural network (CNN) algorithm. Then, it was applied to CT image diagnosis of 100 patients with severe lung infection in The Second Affiliated Hospital of Fujian Medical University hospital and compared with traditional methods, and its sensitivity, specificity, and accuracy were compared. It was found that the single training time and loss of U-Net + DC algorithm were reduced by 59.4% and 9.8%, respectively, compared with CNN algorithm, while Dice increased by 3.6%. The lung contour segmented by the proposed model was smooth, which was the closest to the gold standard. Fungal infection, bacterial infection, viral infection, tuberculosis infection, and mixed infection accounted for 28%, 18%, 7%, 7%, and 40%, respectively. 36%, 38%, 26%, 17%, and 20% of the patients had ground-glass shadow, solid shadow, nodule or mass shadow, reticular or linear shadow, and hollow shadow in CT, respectively. The incidence of various CT characteristics in patients with fungal and bacterial infections was statistically significant (

P
<
0.05

). The specificity (94.32%) and accuracy (97.22%) of CT image diagnosis based on U-Net + DC algorithm were significantly higher than traditional diagnostic method (75.74% and 74.23%), and the differences were statistically significant (

P
<
0.05

). The network of the algorithm in this study demonstrated excellent image segmentation effect. The CT image based on the U-Net + DC algorithm can be used for the diagnosis of patients with severe pulmonary infection, with high diagnostic value.
Research on Evaluation of Green Smart Building Based on Improved AHP‐FCE Method
Authors: Xu Song , Sun Yao
Published: November 2021

With the accelerated pace of urbanization, green buildings and green smart buildings gradually come into people’s vision and are highly valued by all sectors of society on the premise of meeting sustainable development strategy. Firstly, this paper selects 7 first‐level index factors and 20 second‐level index factors to establish the green smart building evaluation system. Secondly, this paper uses the analytic hierarchy process‐fuzzy comprehensive evaluation (AHP‐FCE) method to determine the weight of each secondary index. Finally, the feasibility of the evaluation system is verified by case analysis, and some suggestions on green smart building are put forward.
Identification of Differentially Expressed Genes Reveals BGN Predicting Overall Survival and Tumor Immune Infiltration of Gastric Cancer
Authors: Chen Weizhi , Yang Zhongheng
Published: November 2021

Gastric cancer (GC) is one of the most widely occurring malignancies worldwide. Although the diagnosis and treatment strategies of GC have been greatly improved in the past few decades, the morbidity and lethality rates of GC are still rising due to lacking early diagnosis strategies and powerful treatments. In this study, a total of 37 differentially expressed genes were identified in GC by analyzing TCGA, GSE118897, GSE19826, and GSE54129. Using the PPI database, we identified 17 hub genes in GC. By analyzing the expression of hub genes and OS, MFAP2, BGN, and TREM1 were related to the prognosis of GC. In addition, our results showed that higher levels of BGN exhibited a significant correlation with shorter OS time in GC. Nomogram analysis showed that the dysregulation of BGN could predict the prognosis of GC. Moreover, we revealed that BGN had a markedly negative correlation with B cells but had positive correlations with CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells in GC samples. The pan-cancer analysis demonstrated that BGN was differentially expressed and related to tumor-infiltrating immune cells across human cancers. This study for the first time comprehensively revealed that BGN was a potential biomarker for the prediction of GC prognosis and tumor immune infiltration.
Evolutionary Game and Numerical Simulation of Cultivated Land Protection Policies Implementation in China
Authors: Lu Xinhai , Zhang Yanwei , Zou Yucheng
Published: November 2021

The effective implementation of cultivated land protection policies (CLPP) has important practical significance for improving China’s food security and ecological security. The central government, local governments, and farmers have mutually restricted and influencing interest relations. At the same time, the codes of behavior of multistakeholders also affect the implementation of CLPP in the social system. Therefore, this article discusses the behavioral tendencies and game relationships of relevant stakeholders in the implementation of CLPP from the perspective of evolutionary games and portrays a cognitive decision-making process closer to reality. Finally, numerical simulation reveals the key variables that affect the stability strategy. Results show the following: (1) As the main body of system supply, the central government should reconstruct the political achievement evaluation system and improve the status of the effective implementation of cultivated protection policies in the political achievement evaluation of local governments. (2) The central government should increase incentives for local governments to implement CLPP and increase penalties for violations to improve the effectiveness of policy implementation. (3) To optimize the actual implementation of CLPP, increasing awareness of farmers’ rights protection, reducing rights protection costs of farmers, and increasing the constraints on the flexible implementation of CLPP are necessary.
Microstructure and Performances for Wear‐Resistant Steel through the WAAM Technology
Authors: Ying Meng , Guo Chun , Li Yun , Kang Tai Yu , Liu Wu Meng , Wu Sui Song
Published: November 2021

This work describes the wire arc additive manufacturing (WAAM) approach used to fabricate parts from wear‐resistant steel. The microstructure, crystal structures, and mechanical properties of the resulting samples were thoroughly analyzed. The wear‐resistant steel parts demonstrated good forming, no internal defects, good metallurgical bonding, and excellent wear resistance. The metallographic analysis confirmed that the main phase was ferrite. The microhardness of the sample along its cross section was uniform in both horizontal and vertical directions and equals to 464.7HV0.2 and 482.4 HV0.2, respectively. The average values of tensile strength, elongation ratio, and room temperature Charpy shock were equal to 945.3 MPa, 4.3%, and 5 J, respectively.
A New Conformable Fractional Derivative and Applications
Authors: Kajouni Ahmed , Chafiki Ahmed , Hilal Khalid , Oukessou Mohamed
Published: November 2021

This paper is motivated by some papers treating the fractional derivatives. We introduce a new definition of fractional derivative which obeys classical properties including linearity, product rule, quotient rule, power rule, chain rule, Rolle’s theorem, and the mean value theorem. The definition

D

α

f

t

=

lim

h
⟶
0

f

t
+
h

e

α
−
1

t

−
f

t

/
h

,

for all

t
>
0

, and

α
∈

0,1

. If

α
=
0

, this definition coincides to the classical definition of the first order of the function

f

.
Renewable Energy Certificate Trading via Permissioned Blockchain
Authors: Wang Dong , Xuan Jiaxing , Chen Zhiyu , Li Da , Shi Rui
Published: November 2021

With the continuous advancement of the green certificate trading mechanism, information verification needs to span multiple departments, which causes the application process cumbersome and human errors. In order to solve problems of cumbersome issuance process of the renewable energy certificate (REC) and the inflexible pricing mechanism, in this paper, a hybrid REC trading system was proposed based on an permissioned blockchain technology (BT), which combined advantages of the BT and the continuous double auction (CDA). The operation process of the system was introduced in detail, and the view change protocol in the Practical Byzantine Fault Tolerance algorithm was revised according to the characteristics of the system to improve the system stability. The continuous double auction rule was also introduced in the system. And corresponding bidding strategies were designed to maximize the revenue of users (buyer and seller) and transaction probability. The simulation experiment proves that the bidding mechanism can flexibly adjust the REC price according to the supply and demand relationship. At the same time, the effectiveness and feasibility of trading rule and bidding strategy were also verified.
LncRNA SNHG15 Promotes Oxidative Stress Damage to Regulate the Occurrence and Development of Cerebral Ischemia/Reperfusion Injury by Targeting the miR-141/SIRT1 Axis
Authors: Kang Mingming , Ji Fangchao , Sun Xingyuan , Liu Hongbin , Zhang Chenxin
Published: November 2021

Ischemic stroke is a kind of disease with high mortality and high disability, which brings a huge burden to the public health system (Hu et al. (2017)), and it poses a serious threat to the quality of life of patients. Cerebral ischemia/reperfusion injury is an important pathophysiological mechanism. This study aims to assess the mechanism of SNHG15 in the occurrence and development of cerebral ischemia/reperfusion injury of nerve cells and to investigate its potential value for diagnosis and treatment. SNHG15 targeted miRNA molecules and target genes were predicted with bioinformatics tools such as StarBase and TargetScan. The process of ischemic reperfusion in cerebral apoplexy in normal cultured and oxygen-glucose-deprived and reoxygenated neurons was simulated with RT-PCR and western blot technique. The expressions of SNHG15 and miR-141 were detected with qPCR, and the expressions of SIRT1 and p65, TNF-α, ROS, iNOS, and IL-6 were detected with western blot. Meanwhile, SNHG15 siRNAs and miR-141 mimics were transfected for SH-SY5Y, with western blot testing. And the expressions of miR-141, SIRT1, and p65, TNF-α, ROS, iNOS, and IL-6 were tested. According to the prediction with bioinformatics tools of StarBase and TargetScan, miR-141 is the target of lncSNHG15. In the luciferase reporter plasmid double-luciferase assay, miR-141 and SIRT1 were defined as the target relationship. In the oxygen-glucose-deprived reoxygenation model group, SNHG15 expression increased, miR-141 expression decreased, SIRT1 expression increased, and the expressions of p65, TNF-α, ROS, iNOS, and IL-6 decreased. In the SNHG15-siRNA-transfected oxygen-glucose-deprived reoxygenation cell model group, miR-141 expression increased, SIRT1 expression decreased, and the expressions of p65, TNF-α, and IL-6 increased compared with the si-NC group. In the miR-141-mimic-transfected oxygen-glucose-deprived reoxygenation cell model, SNHG15 expression decreased, SIRT1 expression decreased, and the expressions of p65, TNF-α, IL-1β, and IL-6 increased. In conclusion, SNHG15 expression increased during the process of oxygen-glucose-deprived reoxygenation, and the oxidative stress process was reduced by miR-141/SIRT1.
Evaluation Method of Chemical Technology Safety Practical Operation Ability Based on Stochastic Model
Authors: Wang Xiaotong
Published: November 2021

The current evaluation method does not consider the coordination and overall situation of various practical skills, which affects the evaluation contact degree and leads to hidden dangers of production safety. Therefore, an evaluation method of chemical technology safety practical operation ability based on a stochastic model is proposed. Using association rules to design the feature mining algorithm of practical operation ability, combined with crosslayer coding strategy, the mapping relationship between safety accidents and practical operation ability is established. The chemical safety practical operation skills are simulated by a random model, and the practical operation skills are classified and coordinated according to the simulation predictive control results. According to the coordination results, the evaluation index system is constructed, the index weight is determined, and the evaluation model of chemical technology safety operation ability is constructed. The experimental results show that the maximum connection degree of the evaluation method designed in this paper is 88.06%, and the evaluation results are more accurate, which is helpful to improve the production safety of chemical enterprises.
Applicability of a Novel Wearable Wireless Electrocardiogram Monitoring Device (Spyder) for Arrhythmia Detection in Patients with Suspected Cardiac Arrhythmias
Authors: Van Chien Do , Thanh Binh Nguyen , Dung Nguyen , Truong Son Pham
Published: November 2021

Introduction. In clinical practice, many cardiovascular symptoms can be caused by arrhythmias that are not detected by electrocardiography (ECG) or 24–48 h Holter ECG monitoring. Aims. To describe the efficacy and applicability of a new device (Spyder) in detecting cardiac arrhythmias with midterm ECG monitoring. Methods. A descriptive, prospective study was performed on 26 consecutive patients who underwent midterm ECG monitoring with the novel ECG patch device (Spyder). The study was conducted over a 6-month period from August 2020 to February 2021. Results. Twenty-six patients (mean age, 57.8 ± 12.5 years; men, 77%) wearing a Spyder wireless ECG-monitoring device were recruited. The mean wearing time was 84 hours. The main indications for using the device were detection of recurrent atrial fibrillation after radiofrequency ablation (30.7%) and screening for atrial fibrillation after cryptogenic stroke (23.1%). All ECG monitor recordings obtained during the study period were of good quality. The device detected 12 episodes of atrial fibrillation in eight patients, one episode of ventricular tachycardia, one supraventricular tachycardia event, one case of paroxysmal third-degree atrioventricular block, and five cases of frequent premature ventricular contraction. The time to detection of the first episodes of atrial fibrillation and ventricular and supraventricular tachycardia was 28.8 and 47 hours, respectively. Conclusions. The new wearable wireless ECG-monitoring device (Spyder) is a feasible and effective method for the detection of cardiac arrhythmias.
Geographical Distribution of Emergency Services Times in Traffic Accidents in Extremadura
Authors: Morales-Gabardino José Antonio , Redondo-Lobato Laura , Ribeiro João Meireles , Buitrago Francisco
Published: November 2021

Objective: To analyze the response time and transport time taken by the emergency medical services (EMS), considering their urban or rural location, to attend traffic accident casualties that occurred in the different geographical areas of Extremadura (Spain) from 2012 to 2015. Methods: This was a cross-sectional study of the data recorded by the Emergency Response Coordination Center 112 (ERCC-112) from traffic accidents attended by EMS. Response time was defined as the time elapsed from the request-for-care receipt until arrival of the EMS at the accident scene, and transport time as that from leaving the scene until arrival to the referral hospital. Rural EMS were those based in locations where there is no hospital, and urban EMS those located in towns or cities with a hospital. Results: During the 4-year period studied, 5,572 traffic accidents requested assistance through the ERCC-112. From the 2,875 accidents (51.9%) in which EMS were mobilized, 55.4% occurred in urban roads and the remaining in interurban ones. A total of 113 people (mean age 48.4 ± 19.0 years, range 15–84 years) died at the accident scene or before arrival to the hospital, 88.5% of them in interurban accidents. The average response time of urban and rural EMS was 10.7 ± 7.3 and 18.0 ± 12.6 min (p < 0.001), respectively, and the average transport time was 13.2 ± 11.7 and 45.2 ± 25.0 min (p = 0.009). Response time was longer than the 30-min optimum only in the most peripheral areas of Extremadura, while transport time exceeded the optimum of 90 min in the eastern regions of two health areas (Cáceres and Don Benito-Villanueva). 19.1% of the victims attended by rural EMS were classified as having a serious prognosis or as having died, as compared with 11.2% (p = 0.048) of those attended by urban EMS. Conclusions: The geographical location of EMS in Extremadura (Spain) guarantees adequate response times in traffic accidents, both in rural and urban areas. However, recommended transport times were occasionally exceeded in the most peripheral areas, due to hospital location.
Dietary Omega-3 Fatty Acid Intake and Mortality in CKD Population: A 1999–2014 NHANES Analysis
Authors: Li Wei-Lan , Zhang Nan-Hui , Ge Shu-Wang , Xu Gang
Published: November 2021

Introduction: High risk of early death, especially contributed to cardiovascular disease, exists in patients who have chronic kidney disease (CKD). And the burden of cardiovascular disease is able to be lightened by an increase in omega-3 polyunsaturated fatty acid (omega-3 PUFA). A diet high in omega-3 PUFA in the general population is protective, although it is inconclusive about its beneficial role in the CKD population. Methods: From the 1999 to 2014 National Health and Nutrition Examination Surveys (NHANES), we can collect 2,990 participants who suffered from CKD, who were classified into 4 groups: <0.86, 0.87–1.30, 1.31–1.92, and 1.93–9.65 g/day based on NHANES 24-h dietary recall questionnaire dietary omega-3 PUFA. Moreover, their mortality details were available to be obtained by linking NHANES to the National Death Index. The associations between dietary omega-3 PUFA and mortality were evaluated by constructing multivariable Cox proportional hazards models. Results: Over 8 years of a median follow-up, 864 deaths were recorded. The adjusted hazard ratios (95% confidence interval) for all-cause mortality of the diseased people with CKD in the 2nd (0.87–1.30 g/day), 3rd (0.87–1.30 g/day), and 4th (1.93–9.65 g/day) quartiles of dietary omega-3 PUFA were 0.94 (0.72, 1.23), 0.74 (0.54, 1.02), and 0.67 (0.48, 0.93), respectively, versus those with the lowest quartile of dietary omega-3 PUFA intake (<0.86 g/day) (p for trend = 0.011). Conclusion: There may be a inverse relation of dietary omega-3 PUFA intake and all-cause mortality in patients with CKD. Therefore, an increase of dietary omega-3 PUFA may be encouraged to be used clinically in patients with CKD.
Management of Persistent SARS-CoV-2 Infection in Patients with Follicular Lymphoma
Authors: Martínez-Barranco Pilar , García-Roa María , Trelles-Martínez Roberto , Arribalzaga Karmele , Velasco María , Guijarro Carlos , Marcos Javier , Campelo Carolina , Acedo-Sanz Juan Manuel , Villalón Lucía , Ricard Pilar , García-Bueno María José , Pérez-Fernández Elia , Rodríguez-Caravaca Gil , Peñalver Francisco-Javier
Published: November 2021

Introduction: There is no consensus on the management of the coronavirus disease (COVID-19) in patients with secondary immunosuppression due to either an underlying hematological disease or to the effects of immunochemotherapy (ICT). Some of them may present persistent infection with multiple relapses of COVID-19, requiring several admissions. This study evaluated the clinical characteristics and outcomes after treatment of 5 patients with follicular lymphoma (FL), previously treated with ICT, who developed several episodes of COVID-19. Methods: We analyzed the clinical evolution and response to treatment with antiviral agent, steroids, and convalescent plasma in 5 patients with FL and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persistent infection. Reverse transcriptase polymerase chain reaction tests and peripheral blood immunophenotype were performed for all patients. Results: All patients required hospitalization due to pneumonia with severity criteria and were re-admitted after a median of 22 days (13–42) from the previous discharge. They all showed B-cell depletion by immunophenotyping, and no traces of immunoglobulin antibodies against SARS-CoV-2 were detected in any of the cases. The survival rate was 80%. Conclusion: The combination therapy evidenced clinical benefits, demonstrating its capacity to control infection in immunosuppressed FL patients treated with ICT.
Studies on the habitats of Grey Francolin Francolinus pondicerianus (J.F. Gmelin, 1789) (Galliformes: Phasianidae) in northern districts of Tamil Nadu, India
Authors: M. Pandian
Published: November 2021

This paper pertains to the habitats of the Grey Francolin Francolinus pondicerianus with specific reference to populations, habitat type, vegetation, foraging, impact of human dwellings, and probable threats to  populations in 20 villages covering four northern districts of Tamil Nadu, India. A total of 252 individuals were enumerated. During the non-breeding season, birds move in small groups of 2–6. Of four habitats identified, the maximum number of 143 birds was observed foraging in grasslands, while 61 were seen in dry fallow agricultural lands, 37 in dry lakes/canals, and 11 in harvested fields. No significant association was observed between habitat type and bird behaviour. They feed on termites and spilled paddy grains. Males have repeated loud calls and fight with each other. Four species of tall grasses, six of stunted trees and two shrubs were identified to provide bird habitat. Birds preferred to live away from human dwellings, with 193 found 1,000 m away from settlements. The study area continues to be a suitable habitat for Grey Francolin populations, hence this habitat needs protection.