bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression of VEGFR-3 in the lymphatic vessels of the human gum lamina proper within the age and inflammation
Authors: Speranskaya Ekaterina M. , Golubtsova Natalia N. , Derevyanchenko Svetlana P. , Denisenko Larisa N.
Published: July 2023

Activation of vascular endothelial growth factor VEGFR-3 leads to proliferation, differentiation and migration of lymphatic endothelial cells. The role of this factor in periodontal tissues in normal and inflammatory conditions requires extensive study. The purpose of this study: to study the distribution and expression of VEGFR-3 in the lymphatic vessels of the gum lamina proper during inflammation and the use of a diode laser in young and mature people. Slices of human gum biopsy material were studied by immunohistochemical method. As a result of the research , it was found that in the patients with conditionally healthy periodontal tissues, the number of lymphatic vessels depends on the age and differs in young patients compared to mature patients by 1.2 times. Simultaneouslyбол, it was found that in the control groups, the majority of vessels do not contain VEGFR-3 or have weak receptor expression regardless of age. The tendency to VEGFR-3-mediated increasing of the number of lymphatic vessels during the inflammation is observed only at the age of 41 to 60, however, the intensity of the expression of the VEGF type 3 receptor in chronic gingival inflammation shifts towards the increasing of the vessels with medium and strong VEGFR-3 expression in both groups. As a result of the study, it was found that the tendency to change the number of VEGFR-3-positive vessels is observed only in inflamed gum tissue in patients after 41. Diode laser has a stimulating effect on VEGFR-3-mediated vascular circulation in young patients, while in mature patients, diode laser therapy leads to increase the part of lymphatic vessels with medium and strong expression of the studied receptor, but practically does not affect on the number of detected vessels.
The effect of Transobturator Tape (TOT) on female sexual and psychological functions: A multi centered prospective study
Authors: DEMİR Demirhan Örsan , ÖZGÜR Berat Cem , DEMİRBAS Arif , YAZAR Veli Mert , AKSELİM Burak , YÜCETÜRK Cem Nedim , KAÇAN Turgay
Published: July 2023

AIM:

The aim of the present study is to identify the recovery rate after Transobturator Tape (TOT) surgery of social, physical, sexual and psychological problems caused by SUI in females..

METHODS:

A total of 36 sexually active women were evaluated according to their self-perception of the quality of their life. They answered the following questionnaires; the Beck Depression Inventory (BDI), the Female Sexual Function Index (FSFI) and the Short Form-36 Health Survey (SF-36).

RESULTS: A statistically significant increase of mean 6.47 points was determined in the 3rd month FSFI scores. Also seven parameters of SF-36 questionnaire between the preoperative and 3-month postoperative values were significantly changed. (p
A New Marker In The Diagnosis Of Acute Complicated Appendicitis In Adult Patients: Neutrophil/Albumin Ratio
Authors: SAHİN Serdar
Published: July 2023

ABSTRACT

Aim: Our study aims to search the effectiveness of neutrophil/albumin ratio (NAR) in distinguishing between acute appendicitis (AA) and acute complicated appendicitis (ACA) and to find the best cut-off point of neutrophil/albumin ratio (NAR) for the diagnosis of ACA.

Material and method: This study was performed using data from 453 adult patient who underwent appendectomy and divided into two groups as AA and ACA. Demographic data, preoperative white blood cell count (WBC), neutrophil lymphocyte ratio (NLR), neutrophil/albumin ratio (NAR), C-reactive protein value (CRP) surgical outcomes, and pathological outcomes were retrospectively assessed for each groups.

Results: In our study, 362 patients were in the AA group and 91 patients were in the ACA group. WBC, NLR, CRP and NAR were significant parameters in differentiating acute appendicitis from acute complicated appendicitis. Among these parameters, NAR; AUROC sensitivity and specificity values were stronger than others. (AUROC: 0.963, sensitivity: 95.6%, specificity: 85.7%). As a result of the ROC curve analysis, a cut-off value of 2.79 mg/dl was found.

Conclusion: NAR is a novel inflammatory marker simply detected through routine preoperative blood results, with no additional time or cost. The neutrophil/albumin ratio (NAR) is a fast, easy to access and reliable parameter to differentiate AA from ACA.
PRİMER ANTERİOR OMUZ ÇIKIĞINDA KONSERVATİF TEDAVİ YETERİ KADAR BAŞARILI MI?
Authors: EREN Toygun Kağan , ERDOĞAN Atakan , AKTEKİN Cem Nuri
Published: July 2023

Amaç: Primer anterior omuz çıkığı nedeniyle hastaneye başvuran hastaların tedavi sonuçlarını, tekrar çıkık oranlarını ve tedavi sonuçlarına etki eden faktörleri değerlendirmek

Gereç ve Yöntem: Ocak 2016 ve Ocak 2020 tarihleri arasında, ilk kez (primer) anterior omuz çıkığı nedeniyle hastanemize başvuran ve kapalı redüksiyon sonrası geçici immobilizasyon yöntemiyle konservatif olarak tedavi edilen hastaların verileri değerlendirildi. Daha önceden çıkık öyküsü olan, romatolojik hastalığı olan veya verileri eksik olan hastalar çalışmaya dahil edilmedi. Hastaların tekrar çıkık öyküsü olup olmadığı; eğer tekrar çıkık geliştiyse, ilk travmadan ne kadar süre sonra gerçekleştiği bilgileri incelendi. Ayrıca, tüm hastaların fonksiyonel değerlendirmeleri Oxford Shoulder Instability Score (OSIS) ile yapıldı.

Bulgular: Çalışmaya 43 hasta dahil edildi. Hastaların ortalama yaşı 45,23 ± 17,2 olup hasta yaşları 20-76 arasındaydı. Hastaların 33’ü (%76,7) erkek, 10’u (%23,3) kadındı. Hastaların ortalama takip süresi ise 48,8 ± 12,4 olarak bulundu (En az 31, en çok 86 ay). Hastaların son takipteki ortalama OSIS değeri 45 ± 3,45 olarak bulundu. Hastaların takiplerinde, 21 hastada (%48,8) tekrar omuz çıkığı görüldü. Kırk yaş üstü ve 40 yaş altındaki hastalar karşılaştırıldığında tekrar çıkık oranları sırasıyla, 9/25 (%36) ve 12/18 (%66,6) olarak bulundu (p=0,094). Kırık eşlik eden 6 hastada rekürren omuz çıkığı görülmedi.

Sonuç: Primer anterior omuz instabilitesi sonrası, geçici immobilizasyon ile konservatif tedavi edilen hastalarda tekrar çıkık görülme oranları yüksek olduğu bulunmuştur. Proksimal humerusta eşlik eden kırık varlığında tekrar çıkık daha az görülmüştür.
Kadınların Algıladıkları Meme Kanseri Riskinin Belirlenmesi
Authors: YAKIT AK Eda , ŞEN Mehmet Ali
Published: July 2023

Amaç: Bugün Türk kadınları arasında meme kanseri en sık görülen kanser olma özelliğini taşımaktadır. Çalışma, kadınlar arasında meme kanseri farkındalığı ve korunma davranışlarının belirlenmek amacıyla tanımlayıcı ve prospektif olarak planlandı,. Gereç ve Yöntemler: Çalışma Ocak-Şubat 2023 tarihleri arasında online anket yöntemi ile 20-50 yaş arasındaki 628 kadın ile gerçekleştirildi. Veriler Tanıtıcı bilgi formu ve Champion’un Sağlık İnanç Ölçeği (CSİMO) ile toplandı. Veriler bir istatistik programı ile değerlendirildi. Tanımlayıcı veriler, ortalama, standart sapma, sayı ve yüzdelik dağılımları ile gösterildi. Verilerin karşılaştırılmasında ki kare testi kullanıldı. İstatistiki ölçümlerde anlamlılık değeri 0,05 olarak belirlendi. Bulgular: Çalışmamızda kadınların, yaş ortalamaları 27,59±7,58, %67,7’si bekar ve %35’i en fazla ilkokul mezunuydu. Kadınların %19,7’sinin akrabalarında meme ca öyküsü bulunuyordu, Kadınların %90,6’sının meme ile ilgili sorun yaşamadığı ve %67,2’si meme kanseri erken tanı yöntemleri hakkında bilgilendirildiği belirlendi, Katılımcıların %72,5’inin meme muayenesi olmadığı, %87,6’sı mamografi çektirmediği ve %46,8’i Kendi kendine meme muayenesi (KKMM) yapmadığı belirlendi. Kadınların CSİMO alt boyutlarından orta düzeyde puan aldıkları saptandı. KKMM yapmayı medeni durum, çalışma durumu, meme kanseri teşhisi hakkında bilgi sahibi olma ve mamografi ve klinik muayene merkezlerini bilme durumlarının etkilediği belirlendi. Sonuç: Kadınların meme kanseri farkındalığının yeterli düzeyde olmadığı görüldü. Erken teşhis ve tarama merkezlerinin tanıtımı ve erişilebilirliği artırılmalıdır. Toplumu bilinçlendirecek bilgilendirme çalışmaları planlanmalıdır. Bu nedenle özellikle kadınların meme kanserine yönelik duyarlılığını artıracak çalışmalara ihtiyaç bulunmaktadır.
Kronik Böbrek Yetmezliği Hastalarında Kaşıntı Semptomunun Gece Uyku ve Yaşam Kalitesine Etkisi
Authors: TÜRKER Esra , TANRIKULU Gözdenur
Published: July 2023

AMAÇ: Bu çalışmanın amacı kronik böbrek yetmezliği olan ve hemodiyaliz tedavisi alan hastalarda görülen kaşıntının, onların uyku ve yaşam kalitesine etkisinin belirlenmesidir.

GEREÇ VE YÖNTEM: Tanımlayıcı ve kesitsel tipteki bu araştırma kronik böbrek yetmezliği olan 180 hasta ile Ankara il merkezinde bulunan üç özel diyaliz merkezlerinde Mart-Temmuz 2021 tarihleri arasında yapılmıştır. Çalışmanın verileri Bilgi Formu, 5-D Kaşıntı Ölçeği, Richard-Campbell Uyku Ölçeği ve SF 36- Yaşam Kalitesi Ölçeği kullanılarak elde edilmiştir.

BULGULAR: Çalışmada yer alan hastaların orta şiddette kaşıntı yaşadığı belirlenmiştir. 5-D kaşıntı ölçeği ile Richard-Campbell Uyku Ölçeği arasında orta seviye ve negatif yönde anlamlı ilişki belirlenmiştir (r=-,265,p
Lymphoma Accompanyıng Pneumoconıosıs; Case Report
Authors: ÖZGÜN Serhat , SARI Gülden , KOYUNCU Adem , BENLİ Fatma Tanrıkulu , ŞİMŞEK Cebrail
Published: July 2023

Non-Hodgkin Lymphoma (NHL) is the most common hematological malignancy, and Diffuse Large B-Cell Lymphoma (DLBCL) is the most common histological type. A 56-year-old male patient was admitted to our clinic with complaints of shortness of breath and fatigue for 1 month. It was learned in his professional history that he had been a dental technician for 30 years. He was diagnosed with pneumoconiosis in 2020 and his chest radiograph was q/t 3/3 according to the International Labor Organization (ILO) International Classification of pneumoconiosis radiographs. Laboratory examinations revealed an increase in erythrocyte sedimentation rate (ESR 50 mm/h) and serum lactate dehydrogenase (LDH 368 IU/L) levels. On thoracic computed tomography (CT), enlarged lymph nodes and lymphadenopathies (LAP) with local conglomeration and calcifications in the mediastinal, subcarinal and bilateral hilar areas were seen. Widely disseminated inhomogeneous mass-like consolidation areas, including internal calcifications, extending from the hilum to the parenchyma in both lungs, were observed more prominently in the right middle zone. Diffuse interstitial thickenings, infiltrations and centrilobular nodular density increases in both lungs, nodular consolidated areas with recessed contours and nodules and ground glass densities were observed, especially in the left upper zone. In the lateral part of the left 5th rib, a heterogeneous soft tissue mass of approximately 12x5 cm, causing cortical destruction, invading the surrounding soft tissues and muscle planes, and containing internal cystic-necrotic components was observed. On abdominal CT, enlarged lymph nodes and LAPs, some of which contain calcifications, were observed in the abdomen. The pathology result was reported as Diffuse B-Cell Lymphoma in the patient who underwent transthoracic biopsy due to radiographic appearances that are not typical for PMF. Here, we presented a case of pneumoconiosis with occupational carcinogen exposure and presenting with lymphoma.
Determinants of Saving Decision on Fixed Deposits in Non-Bank Finance and Leasing Institutions in Sri Lanka
Authors: Dharmawansa Asanka , Madhuwanthi RAM
Published: July 2023

The objective of this article is to identify the determinants of saving decisions on fixed deposits. The effect of customers' prior experience with Non-Bank Finance & Leasing Institutions (NBFLI) has been investigated as a mediation factor. Structural Equation Modelling (SEM) in AMOS has been used to analyze the results and confirmed the results by using the bootstrap technique of SEM. The results show that the stability of the NBFLIs, security for the fund, interest rate of the fixed deposits, and quality and reliability of the service directly affect the decision to save fixed deposits. The institution's geographical location has not directly affected the decision on fixed deposits. The factors of the security, interest rate, quality, and reliability of the service have an indirect effect on the decision of saving fixed deposits with prior experience, except for the factor of stability of the institutions.
RESCHEDULING USING THE PDM METHOD WITH MICROSOFT PROJECT 2021 IN THE URBAN SLUM QUALITY IMPROVEMENT PROJECT FOR AIR SANTRI, BANJAR REGENCY
Authors: Nurcahya Naura Rasyida , Yuliana Candra , Widiastuti Endah
Published: July 2023

In project development planning is a measure of the success of a project, which can determine the allocation of funds, time and quality to be obtained. This planning is combined with the use of special planning software, namely Microsoft Project 2021, which with this software can help make rescheduling easy and can track developments in the field. The data was analyzed using the Precedent Diagram Method (PDM) using the Microsoft Project 2021 application and the resulting plan is a network of all project work scopes. The results of the scheduling analysis of the Air Santri Urban Slum Quality Improvement Project, Banjar Regency, using the Microsoft Project 2021 application is that the project was carried out for 335 days obtained based on the scope of work with the largest duration of this project, namely 12 months 25 days starting on May 21 2021 ending on June 15, 2022. The total duration for each scope of work is Public Open Space (RTP) for 331 days, Retaining Walls (DPT) for 335 days, Roads for 139 days, Pier for 96 days, Waste Management Area (TPS) 170 days duration, SPAL DT 57 days duration and Clean water installation 201 days duration. Keywords: Microsoft Project 2021, Precedence Diagram Method (PDM), scheduling.
MATERIAL MANAGEMENT SYSTEM ON NARROW LAND IN THE TOTAL REHAB PROJECT OF THE NEW PEMURUS HEALTH CENTER
Authors: Muchlis Muhammad Ferdy Perdana , Kartadipura Retna Hapsari , Karim Abdul
Published: July 2023

Several methods are commonly used to overcome material management system problems in projects, these methods include the material selection stage, supplier selection, material purchase stage, material delivery stage, material acceptance stage, material storage stage, material production stage, and material inventory level. Before entering the material management system, you must determine what materials are entered into the system, one of which uses Pareto analysis. Pareto diagrams are a standard method of quality control to get the most out of it or choose the main problems and after all are considered as a simple approach that can be understood by less-educated workers, as well as as a tool for solving in a fairly complex field. From the results of Pareto analysis calculations, it is known that the types of materials included in the material management system are Reinforced Iron, Formwork, and Ready Mix. Good material management, it will make it easier to handle work based on procedures that have been arranged systematically. With a clear and systematic management format, it will be able to minimize the occurrence of things that will cause losses on the part of the company. Keywords: Pareto Analysis, Management System, Materials.
THE EFFECT OF ADDED NICKEL SLAG TO COMPRESSION AND SHEAR STRENGTH ON LATERITE SOIL SOUTH KALIMANTAN
Authors: Dewi Ayu Mustika , Rusdiansyah Rusdiansyah
Published: July 2023

Laterite soil is an embankment soil that is often used because it is easy to find and is widely found in South Kalimantan. However, this land has many shortcomings to be used as embankment soil. This is because the lateritic soil has a clay content and a high Plasticity Index (PI) value. So the quality is still questionable to be used as landfill. To overcome this, it is necessary to improve or stabilize the lateritic soil. In this study, the lateritic soil was stabilized by the addition of slag nickel            This study aims to determine the physical characteristics of laterite soil after being given a mixture of nickel slag addition, this study also aims to determine the effect of the percentage of nickel slag on primary consolidation (Sc) of laterite soil. As well as knowing the effect of the percentage of nickel slag on the parameters of shear strength in the form of cohesion (c) and shear angle (f). Consolidation and shear strength specimens were made with 90% of the optimum moisture content. The variations of the nickel slag mixture used in this study were 0%, 5%, 10%, 15%, and 20% of the weight of the soil used.            Based on the results of data analysis, the addition of a mixture of nickel slag in each sample variation can reduce the plasticity index value of the lateritic soil. In addition, the addition of nickel slag also affects the value of the primary consolidation settlement value (Sc) of the laterite soil. The addition of the percentage of nickel slag also affects the parameters of the shear strength of the soil, for the cohesion value (c) of the laterite soil experiences a value that decreases with the increase in the percentage of nickel slag. Meanwhile for the shear angle (φ) of the laterite soil, the value increases with the increase in the percentage of nickel slag.Keywords: laterite soil, nickel slag, plasticity index, consolidation of laterite soil, shear strength of laterite soil
ANALYSIS OF SCHEDULING USING CPM AND PDM METHODS WITH MICROSOFT PROJECT 2019 IN THE REPLACEMENT PROJECT OF SALIM RIVER BRIDGE MATARAMAN
Authors: Safitri Della Ayu , Wardhana Henry
Published: July 2023

The success of an emergency response project is that it can be completed quickly and on time because of the urgency of the situation so that timely management of implementation is needed by making a schedule. This research was conducted to determine the appropriate scheduling method according to the character of the emergency response construction project. Scheduling methods are used in the form of Critical Path Method (CPM) and Precedence Diagram Method (PDM). The analysis was carried out on the duration and dependencies for each work item which was then scheduled with the help of Microsoft Project 2019 to get the results in the form of network diagrams and critical paths. Based on the results of the scheduling analysis the Replacement Project of Salim River Bridge Mataraman, it was found that for the CPM method the project could be carried out for 129 days starting from January 20, 2021 and ending on May 29, 2021 and for the PDM method the project was carried out for 120 days starting from January 20, 2020 and ends on May 20, 2021 earlier than the CPM method. Each method has two critical paths due to the traffic safety and management work required throughout the project.Keywords : Critical Path Method (CPM), Precedence Diagram Method (PDM), Microsoft Project 2019
Penanaman Nilai Pendidikan Islam Melalui Hafalan Asmaul Husna Menggunakan Metode Bernyani pada Anak Usia Dini
Authors: Nurhayati Rika
Published: July 2023

Pendidikan anak usia dini sangat diperlukan dan memiliki tujuan untuk mengembangkan seluruh potensi juga minat anak agar kelak menjadi manusia utuh yang mampu hidup dengan masyarakat disekelilingnya. Tujuan penelitian ini adalah untuk mengetahui pedalaman nilai pendidikan Islam melalui hafalan Asmaul Husna menggunakan metode bernyanyi di RA Al Irsyad. Jenis penelitian ini menggunakan metode deskriptif kualitatif yang fokus pada usaha menggambarkan karakterisik objek menurut perspektif peneliti menggunakan jenis penelitian yang dikenal sebagai penelitian lapangan dengan cara turun langsung ke lapangan untuk mengumpulkan data dan item-item yang disajikan. Hasil penelitian menyangkut kegiatan kegiatan pembelajaran di RA Al Irsyad yaitu pada kegiatan awal, inti dan penutup. Metode bernyanyi mampu membuat anak menjadi mudah dalam menghafal Asmaul Husna. Tentunya dari metode bernyanyi ini terdapat kelebihan dan kekurangan terhadap proses pembelajaran di RA Al Irsyad. Namun dari kekurangan tersebut diharapkan dapat menjadi bahan evaluasi agar terus memperbaiki metode pembelajaran agar berjalan dengan optimal. Adanya penerapan pembelajaran dengan mengunakan metode bernyanyi Islami tentu sangat meningkatkan pengetahuan anak tentang ketuhanan.
DEVELOPING SOCIAL EMOTIONAL USING BCCT MODEL, ROLE PLAYING, AND NATURAL MATERIAL MEDIA IN GROUP B
Authors: Mahfuziah Lisa , Metroyadi Metroyadi
Published: July 2023

Low  social interaction of  children with their friends is a problem in this study. This study aims to determine teacher activities, children's activities, and children's social-emotional development achievements through a combination  of Beyond Center And Circle Time (BCCT) and Role Playing models  with natural material media in group B of TK Negeri 3 Alalak.  Theapproach and type of research used in  this study are qualitative approaches and   types of Classroom Action Research (PTK) in four cycles.  Agroup B of TK Negeri 3 Alalak totaling 20 children were the  subjects of this study. The results of this studyshowed  that children's social emotional development in the  learning process was seen from an increase of 40% at the first meeting, 65% at the second meeting, 85% at the third meeting, and 100% at the  fourth meeting.  The conclusion of this  study based on the results of the study is that the  combination of the Beyond Center And Circle Time (BCCT) model  and Role Playing with natural material media can develop activities and achieve child development results.
DEVELOPING LANGUAGE ASPECTS IN MENTIONING LETTER SYMBOLS IN GROUP B OF NURUTTAQWA KINDERGARTEN BANJARMASIN
Authors: Oktavia Setyana , Agusta Akhmad Riandy
Published: July 2023

This research was motivated  by the lack of development  of  children's  ability to mention letter symbols caused by the  media used by  teachers in the learning process  to recognize letters that did not attract children's hearts, thus making children less enthusiastic and not eager to participate in learning activities.  The purpose of this study is to improve and improve the quality of the learning process of group B in Nuruttaqwa Kindergarten Banjarmasin.  This research approach uses qualitative and quantitative approaches  with the type of classroom action research (PTK) held 4 meetings. Techniques for collecting observations of teacher activities, observation of children's activities, children's learning outcomes, language skills.   The results showed that teacher activity increased with a score of 25 criteria "Very Good" at meeting 4. Children's activity at each meeting increased with a percentage of 84.62% of the criteria being very active at meeting 4. Children's language development with a percentage of 92.31% or 30 children successfully developed at meeting 4.
DEVELOP EARLY LITERACY SKILLS THROUGH COOPERATIVE LEARNING MODELS, MONTESSORI GAME METHODS AND SANDPAPER LETTERS MEDIA
Authors: Laida Alda , Sari Dessy Dwitalia
Published: July 2023

This research was motivated by the low results of children's language development in the aspect of early literacy in recognizing and imitating (writing by mentioning) letters that are still not developed. The purpose ofthis study is teacher activity, child activity, and child development results in showing children's activities in recognizing and imitating (writing by mentioning) letters. This research approach uses a qualitative approach, the type of research is Classroom Action Research (PTK) which is carried out in 2 cycles. This researchwasconducted at Suka Maju Kindergarten, Lunjuk HST Village for the 2021/2022 school year in group A, which amounted to 12 children consisting of 4 boys and 8 girls. Datacollection techniques are carried out by observation, interviews, performances, and evaluation through LKPD. The results showed that teacher activity obtained very good categories, children's activities obtained very active categories, the results of the development of aspec early literacy aspects obtained categories developed as expected (BSH) and developed very well (BSB). The conclusion of this study is the use of cooperative learning models, Montessori game methods  and sandpaper letters media in  developing aspects of early literacy (recognizing and imitating) in group A children of Suka Maju Kindergarten Lunjuk HST Village.
DEVELOP SOCIAL EMOTIONAL IN RECOGNIZING COLORS USING EXPERIMENTAL METHODS WITH EXTRATION MODELS IN GROUP B
Authors: Susanti Sekar Oktaviani Dwi , Faqihatuddiniyah Faqihatuddiniyah
Published: July 2023

The problem in this study is that the children are not independent and impatient in studying Group B in Aisyiyah Busthanul Athafal 36 Kindergarten Banjarmasin. Learning activities are a crucial factor in the success of the learning process carried out through the activities of the teachers. The activity of teachers is the main factor in various achievements, especially in children's learning activities, which affect the success of children's developmental outcomes. However, business and development results are still relatively low. Therefore, the purpose of data collection is to determine the increase in children's developmental activity and outcomes using a combination of extraction models. The type of research used is Classroom Action Research (CAR) which took place with 4 meetings. The research subjects were children of Group B of Aisyiyah Busthanul Athfal 36 Kindergarten Banjarmasin in school year 2021/2022. The results showed that the activity of the teacher at the first meeting was quite good, the second and third meetings in the category of good, the fourth meeting was very good. Student activity at the first meeting met the criteria of being less active, the second met the criteria of being reasonably active, the third met the criteria of being active, and the fourth met the criteria of being very active. The classic completeness of child development outcomes was 30% at the first meeting, 50% at the second meeting, 90% at the third meeting, and 100% at the fourth meeting. Based on these results, it can be concluded that the combination of explicit instructions and demonstration models can improve the outcomes of the activities and the child's development. It is recommended to use this model as an alternative to reinforce the activities of the teacher and the child that have an impact on improving the child's developmental outcomes.
TINJAUAN FLIPPED CLASSROOM PADA MATA KULIAH GEOMETRI TRANSFORMASI MENURUT KERANGKA WILLIAMS AND EGGERT
Authors: Ansori Hidayah , Amalia Rizki , Juhairiah Juhairiah
Published: July 2023

penelitian ini bertujuan untuk mendeskripsikan pelaksanaan pembelajaran flipped classroom pada mata kuliah geometri transformasi pada porgram studi pendidikan matematika FKIP Universitas Lambung Mangkurat. Tujuan pada penelitian ini adalah untuk mendeskripsikan pelaksanaan pembelajaran flipped classroom pada mata kuliah geometri transformasi. Data penelitian merupakan hasil survei pada kelas yang melaksanakan flipped classrom menggunakan instrumen kerangka Williams and Eggert, kemudian data dianalisis menggunakan skala likert dan kategorisasi dan persentase. Kesimpulan (1) mahasiswa setuju mengikuti perkuliahan selalu memperhatikan penjelasan dosen, (2) Pemrosesan kognitif pada umumnya dapat berlangsung dengan baik akan tetapi mahasiswa masih ragu-ragu dapat memikirkan materi perkuliahan, (3) Mahasiswa setuju bahwa mencatat materi perkuliahan penting, di samping juga mahasiswa memberikan garis bawah atau warna dan memberi komentar untuk dipelajari pada persiapan ujian tengah semester atau ujian akhir semester, (4) Mahasiswa meninjau pemrosesan setelah kelas selesai dengan cara melengkapi catatan, memberikan komentar pada buku catatan, akan tetapi mahasiswa masih belum membuat flashcard untuk belajar.  Kata kunci: Flipped Classroom, geometri Transformasi, kerangka Williams and Eggert Abstract: This study aims to describe the implementation of flipped classroom learning in the geometry transformation course in the Mathematics Education Study Program FKIP ULM. The purpose of this research is to describe the implementation of flipped classroom learning in transformation geometry courses.The research data is the result of surveys in classes that carry out flipped classes using the Williams and Eggert, then the data were analyzed using a Likert scale and categorization and percentage. Conclusions (1) students agree to attend lectures always pay attention to the lecturer's explanation, (2) Cognitive processing in general can go well but students are still unsure about being able to think about lecture material, (3) Students agree that taking notes on lecture material is important, besides students provide underlines or colors and provide comments to study in preparation for midterm or final semester exams, (4) Students review processing after class is over by completing notes, commenting on notebooks, but students still haven't made flashcards for study . Keywords: Flipped Classroom, Transformation geometry, Williams and Eggert framework
HUBUNGAN POLA MAKAN BALITA DAN PENDAPATAN ORANGTUA DENGAN KEJADIAN STUNTING PADA BALITA DI WILAYAH KERJA PUSKESMAS LAMPIHONG KABUPATEN BALANGAN
Authors: Farida Ainun , Heriyani Farida , Al Audhah Nelly
Published: July 2023

Stunting merupakan kondisi gagal tumbuh pada balita akibat kekurangan gizi kronis sehingga anak terlalu pendek untuk usianya dan menyebabkan pertumbuhan terhambat. Stunting masih menjadi permasalahan gizi dan tumbuh kembang anak di Indonesia. Berdasarkan data Puskesmas Lampihong Kabupaten Balangan jumlah balita yang mengalami stunting pada Agustus 2021 sebanyak 296 balita (28,3%). Penelitian ini bertujuan untuk mengetahui hubungan pola makan balita dan pendapatan orangtua dengan kejadian stunting pada balita di Wilayah Kerja Puskesmas Lampihong. Penelitian ini dilakukan dengan metode observasional analitik dengan rancangan case control, teknik sampling menggunakan simple random sampling sebanyak 30 responden balita stunting sebagai kelompok kasus dan 30 responden balita tidak stunting sebagai kelompok kontrol analisis data menggunakan analisis bivariate dengan uji chi-square. Hasil penelitian menunjukkan bahwa pola makan tidak tepat 66,7% pada kelompok kasus dan 23,3% kelompok kontrol dan tingkat pendaptan rendah 80,0%  pada kelompok kasus dan 56,7% kelompok kontrol. Hasil statistik didapatkan nilai p=0,002 dan OR=6,571 untuk hubungan pola makan, dan nilai p=0,096 untuk hubungan pendapatan dengan kejadian stunting, sehingga dapat disimpulkan bahwa terdapat hubungan antara pola makan balita dengan kejadian stunting pada balita dan tidak terdapat hubungan pendapatan orangtua dengan kejadian stunting pada balita.
HUBUNGAN KADAR HEMOGLOBIN DENGAN KEJANG DEMAM KOMPLEKS DAN SIMPLEKS
Authors: Anamiyanoor Sinta , Hidayah Nurul , Huldani Huldani
Published: July 2023

Kejang demam merupakan bangkitan kejang yang terjadi karena kenaikan suhu tubuh (suhu diatas 38ºC) yang ditimbulkan oleh proses ekstrakranium. pada anak dengan kadar hemoglobin rendah menyebabkan kemampuan sel darah merah yang mengikat oksigen menurun dan diduga dapat mengakibatkan kejang. Penelitian ini bertujuan untuk menjelaskan hubungan kadar hemoglobin dengan kejang demam kompleks dan simpleks. Penelitian dilakukan dengan Cross Sectional Study dengan jumlah sampel masing-masing 30 untuk kasus kejang demam kompleks dan kejang demam simpleks. Teknik pengambilan sampel dengan metode purposive sampling. Data berupa data sekunder yang diambil dari rekam medik di RSUD Ulin Banjarmasin. Analisis data menggunakan chi-square (R2). Hasil penelitian didapatkan bahwa  9 orang (45%) yang memiliki Hb rendah yang mengalami kejang demam simpleks dan terdapat 11 orang (55%) yang memilki Hb rendah yang mengalami kejang demam kompleks. Terdapat 21 orang (52,5%) yang memiliki Hb normal yang mengalami kejang demam simpleks, dan terdapat 19 orang (47,5%) yang memiliki Hb normal yang mengalami kejang demam kompleks. Hasil analisis data adalah tidak terdapat hubungan yang bermakna (p= 0,584) antara kadar hemoglobin dengan kejang demam kompleks dan kejang demam simpleks.
PROFIL PASIEN TINEA KORPORIS DI POLIKLINIK KULIT DAN KELAMIN RSUD ULIN BANJARMASIN PERIODE 2019-2021
Authors: Tanriati Ismi , Hadi Sukses , Dwi Sanyoto Didik , Savitri Dwiana , Rahmiati Rahmiati
Published: July 2023

Tinea korporis adalah infeksi jamur superfisial pada kulit yang banyak dijumpai pada daerah beriklim tropis. Infeksi ini disebabkan oleh jamur dermatofita seperti Trichophyton sp., Microsporum sp., dan Epidermophyton sp. Tinea korporis terjadi pada kulit tubuh yang tidak berambut. Penelitian ini bertujuan untuk mengetahui profil pasien tinea korporis di Poliklinik Kulit dan Kelamin RSUD Ulin Banjarmasin periode 2019-2021. Metode deskriptif retrospektif dipilih bagi penelitian ini yang diambil melalui rekam medis dan pusat data elektronik. Hasil penelitian ini menunjukkan jumlah kasus pasien tinea korporis periode 2019-2021 sebanyak 86 pasien. Kasus terbanyak terjadi pada kelompok usia 36-45 tahun (22,1%), jenis kelamin perempuan (58,1%), berasal dari daerah Banjarmasin (57,0%), paling banyak dijumpai pada Ibu Rumah Tangga (20,9%), dan tidak memiliki komorbid (88,4%). Gambaran lesi yang sering terjadi yaitu makula, tepi aktif, skuama, batas tegas, dan central healing. Pengobatan antijamur menggunakan terapi kombinasi (60,5%). Pada seluruh pasien tinea korporis tidak dilakukan pemeriksaan KOH 10-20% (100%). Kesimpulan penelitian ini adalah jumlah kasus periode 2019-2021 sebanyak 86 pasien, rentang usia 36-45 tahun, jenis kelamin perempuan, berasal dari daerah Banjarmasin, pekerjaan Ibu rumah tangga, dan tidak memiliki komorbid. Gambaran lesi yang sering terjadi yaitu makula, tepi aktif, skuama, batas tegas, dan central healing. Pengobatan antijamur topikal dan sistemik.
HUBUNGAN DERAJAT DISPLASIA DENGAN JUMLAH SEL GOBLET PADA GAMBARAN HISTOPATOLOGI KOLITIS DI RSUD ULIN BANJARMASIN PADA TAHUN 2020-2022
Authors: Winola Sunata Kanessha , Ary Wibowo Agung , Kustiyah Oktaviyanti Ika Kustiyah Oktaviyanti , Budiwinata Winardi , Rosida Lena Rosida
Published: July 2023

Kolitis merupakan suatu kondisi dimana lapisan mukosa kolon meradang, secara akut maupun kronis. Selama 2 dekade terakhir, insidensi IBD meningkat secara signifikan di Asia. Selain itu, kolitis juga bisa berkembang menjadi suatu keganasan. Hal ini bisa dilihat dengan memantau peningkatan derajat displasia dan pengurangan jumlah sel goblet sejalan dengan progesivitas penyakit. Tujuan dari penelitian ini ialah menganalisis karakeritstik serta hubungan derajat displasia dengan jumlah sel goblet pada kolitis di RSUD Banjarmasin tahun 2020-2022. Penelitian ini menggunakan rancangan penelitian observasional analitik dengan pendekatan cross sectional, menggunakan sampel sebanyak 39 sediaan (preparate/slide) histopatologi pasien kolitis yang diambil dengan teknik total sampling. Hasil dari penelitian ini dianalisis dengan uji Rank Spearman dan ditemukan ada hubungan antara peningkatan derajat displasia dengan penurunan jumlah sel goblet. Semakin tinggi derajat displasia maka semakin rendah jumlah rata – rata sel goblet pada kolitis.
PERBEDAAN KADAR D-DIMER PADA IBU HAMIL DENGAN COVID-19 TANPA DAN DISERTAI PREEKLAMPSIA
Authors: Reiki Hernaldi , Armanza Ferry , Xaverius Hendriyono Fransiskus , Aditya Renny , Rahmiati Rahmiati
Published: July 2023

COVID-19 merupakan penyakit infeksi yang disebabkan oleh virus SARS-CoV-2. Ibu hamil merupakan kelompok yang rentan terinfeksi COVID-19. Preeklampsia merupakan penyakit pada ibu hamil yang ditandai dengan hipertensi pada usia kehamilan > 20 minggu dan proteinuria. D-dimer adalah penanda adanya proses fibrinolisis, sehingga molekul ini berperan sebagai penanda adanya hiperkoagulasi yang berkaitan dengan keparahan COVID-19 dan preeklampsia. Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan bermakna kadar d-dimer pada ibu hamil dengan COVID-19 tanpa dan disertai preeklampsia. Jenis penelitian ini adalah observasional analitik menggunakan desain studi potong lintang dengan pengambilan data secara retrospektif. Hasil penelitian didapatkan 603 subjek, tetapi hanya 65 subjek yang memenuhi kriteria inklusi. Subjek ibu hamil dengan COVID-19 tanpa preeklampsia sebanyak 39 pasien diacak sehingga didapatkan 26 subjek ibu hamil dengan COVID-19 tanpa preeklampsia dan 26 subjek ibu hamil dengan COVID-19 disertai preeklampsia. Pada penelitian ini didapatkan kadar d-dimer ibu hamil dengan COVID-19 tanpa preeklampsia dan disertai preeklampsia berurutan median 1,39 ng/mL dan 1,37 ng/mL dengan nilai minimum 0,42 ng/mL dan 0,28 ng/mL dengan nilai maksimum 5,96 ng/mL dan 5,32 ng/mL Kesimpulan penelitian ini adalah tidak didapatkan perbedaan bermakna kadar d-dimer pada ibu hamil dengan COVID-19 tanpa dan disertai preeklampsia dengan p=0,405.
KARAKTERISTIK PASIEN CHRONIC KIDNEY DISEASE YANG DILAKUKAN HEMODIALISIS DI RSUD ULIN BANJARMASIN SELAMA PANDEMI COVID-19 Tinjauan Terhadap Usia, Jenis Kelamin, Pendidikan, Pekerjaan, Status Pernikahan, Riwayat Penyakit Penyerta, Riwayat Terpajan Virus COVID-19
Authors: Abyuta Wiksa Pranandhira Raden , Yudha Rahman Eka , Khatimah Husnul
Published: July 2023

Chronic Kidney Disease (CKD) merupakan kelainan struktur atau fungsi pada ginjal yang berlangsung selama >3 bulan. Pasien dengan penyakit CKD yang dihemodialisis rentan terpajaan virus COVID-19 karena pasien tersebut memiliki gabungan faktor risiko seperti usia yang tua, sistem kekebalan yang kurang efisien akibat status uremik, diabetes serta hipertensi. Tujuan umum penelitian adalah mengetahui karakteristik pasien Chronic Kidney Disease yang dilakukan hemodialisis di RSUD Ulin Banjarmasin selama pandemi COVID-19. Penelitian ini adalah penelitian deskriptif dengan menggunakan data sekunder dari rekam medis. Teknik pengambilan sampel adalah purposive samplingdengan subyek berjumlah 100 data rekam medis. Hasil dan kesimpulan penelitian ini didapatkan karakteristik usia pasien terbanyak adalah 46-55 tahun sejumlah 41 orang (41%), karakteristik jenis kelamin terbanyak adalah laki-laki sejumlah 58 orang (58%), karakteristik tingkat pendidikan terbanyak adalah SMA sejumlah 47 orang (47%), karakteristik pekerjaan terbanyak adalah ibu rumah tangga sejumlah 22 orang (22%), karakteristik status pernikahan terbanyak adalah menikah sejumlah 91 orang (91%), karakteristik penyakit penyerta terbanyak adalah hipertensi sejumlah 43 orang (43%), dan karakteristik riwayat terpajan virus COVID-19 sejumlah 22 orang (22%).Chronic Kidney Disease (CKD) merupakan kelainan struktur atau fungsi pada ginjal yang berlangsung selama >3 bulan. Pasien dengan penyakit CKD yang dihemodialisis rentan terpajaan virus COVID-19 karena pasien tersebut memiliki gabungan faktor risiko seperti usia yang tua, sistem kekebalan yang kurang efisien akibat status uremik, diabetes serta hipertensi. Tujuan umum penelitian adalah mengetahui karakteristik pasien Chronic Kidney Disease yang dilakukan hemodialisis di RSUD Ulin Banjarmasin selama pandemi COVID-19. Penelitian ini adalah penelitian deskriptif dengan menggunakan data sekunder dari rekam medis. Teknik pengambilan sampel adalah purposive sampling dengan subyek berjumlah 100 data rekam medis. Hasil dan kesimpulan penelitian ini didapatkan karakteristik usia pasien terbanyak adalah 46-55 tahun sejumlah 41 orang (41%), karakteristik jenis kelamin terbanyak adalah laki-laki sejumlah 58 orang (58%), karakteristik tingkat pendidikan terbanyak adalah SMA sejumlah 47 orang (47%), karakteristik pekerjaan terbanyak adalah ibu rumah tangga sejumlah 22 orang (22%), karakteristik status pernikahan terbanyak adalah menikah sejumlah 91 orang (91%), karakteristik penyakit penyerta terbanyak adalah hipertensi sejumlah 43 orang (43%), dan karakteristik riwayat terpajan virus COVID-19 sejumlah 22 orang (22%).
GAMBARAN HASIL PEMERIKSAAN TES CEPAT MOLEKULER MYCOBACTERIUM TUBERCULOSIS DI RSUD ULIN BANJARMASIN TAHUN 2020-2021
Authors: Hartiyah Lidya , Rahmiati Rahmiati , Dwi Santoyo Didik
Published: July 2023

Tuberkulosis (TBC) merupakan penyakit menular yang menjadi isu global dengn populasi yang terinfeksi sehingga menyebabkan 2,5 juta orang meninggal setiap tahunnya. World Health Organization memperkirakan sekitar 9,6 juta jumlah kasus TBC, dengan 5,4 juta terjadi pada jenis kelamin laki-laki, dan 3,2 juta terjadi pada perempuan. Setiap tahun jutaan orang yang mengidap Human Immunodeficiency Virus (HIV) juga mengalami infeksi TBC. Penelitian ini bertujuan untuk mengetahui gambaran hasil pemeriksaan TCM Mycobacterium tuberculosis di RSUD Ulin Banjarmasin pada tahun 2020-2021. Penelitian ini menggunakan metode deskriptif dengan melihat rekam medis sebagai data sekunder. Hasil penelitian menunjukan jumlah pasien TBC dengan hasil pemeriksaan TCM pada tahun 2020-2021 sebanyak 400 sampel. Terbanyak pada kelompok usia lansia akhir (17,5%), jenis kelamin laki-laki (61,6%), MTB tidak terdeteksi sebanyak (46,75%) dan MTB terdeteksi sensitif rifampisin sebanyak (21,25%). Kategori kualitas sputum yang terbanyak adalah mucoid (35%).
PERBEDAAN KADAR CRP PADA REMAJA TERLATIH DAN TIDAK TERLATIH SETELAH LARI INTENSITAS SEDANG 30 MENIT
Authors: Namira Raida , Huldani Huldani , Kaidah Siti , Asnawati Asnawati , Hendriyono FX
Published: July 2023

Aktivitas fisik dapat menimbulkan respons inflamasi. Biomarker inflamasi yang mudah untuk diukur adalah C-reaktif protein. Penelitian ini bertujuan menjelaskan perbedaan kadar CRP sebelum dan setelah lari 30 menit dengan intensitas sedang pada remaja terlatih dan tidak terlatih. Penelitian dilangsungkan melalui Cross Sectional Study pada 15 remaja terlatih yaitu pemain sepak bola dari Klub Perseban Banjarmasin dan 15 remaja tidak terlatih di Banjarmasin yang berkisar umur 16-22 tahun dengan jenis kelamin laki-laki. Teknik pemilihan sampel menggunakan metode purposive sampling. Pengukuran kadar CRP dilakukan sebelum dan setelah lari intensitas sedang 30 menit. Penelitian didapatkan nilai kadar rata-rata CRP 5.3 mg/L pada kelompok remaja terlatih setelah lari intensitas sedang 30 menit dan 11.58 mg/L pada kelompok remaja tidak terlatih setelah lari. Selanjutnya dilakukan uji t tidak berpasangan untuk membandingkan perbedaan (setelah lari) kadar CRP antara 2 kelompok yang dikumpulkan yakni nilai p=0.000 yang menujukkan nampak korelasi berarti. Hasil penelitian ini menyimpulkan bahwa terjadi perbedaan kadar CRP atas remaja terlatih serta tidak terlatih sesudah lari intensitas sedang 30 menit.
HUBUNGAN USIA DAN JENIS KELAMIN DENGAN KEJANG DEMAM SIMPLEK DAN KOMPLEK
Authors: Gusma Fadillah Barra , Hidayah Nurul , Huldani Huldani
Published: July 2023

Kejang demam merupakan penyakit bangkitan kejang yang terjadi pada anak dengan kenaikan suhu tubuh lebih dari 38°C. Kejang demam diklasifikasikan  menjadi 2 jenis kejang, kejang demam simpleks dan kejang demam kompleks, yang diduga berhubungan dengan usia dan jenis kelamin. Tujuan dari penelitian ini adalah untuk mengaetahui hubungan usia dan jenis kelamin dengan kejang demam simpleks dan kompleks pada anak di RSUD Ulin Banjarmasin. Pada anak dengan umur 1-2 tahun sering mengalami kejang demam, yang dimana berkaitan dengan tingkat kematangan otak anak. Pada anak laki-laki sering mengalami kejang demam, dibandingkan anak perempuan hal ini berkaitan dengan proses neurogenesis.  Penelitian dilakukan dengan Cross Sectional Study dengan jumlah 60 sampel. Teknik pengambilan sampel dilakukan dengan metode purposive sampling, yang diambil dari rekam medik di RSUD Ulin Banjarmasin. Analisis data menggunakan chi-square (R2). Hasil penelitian menunjukkan sebagian besar pasien berusia < 2 tahun (56.7%), jenis kelamin laki-laki (65%), Hasil analisis data adalah tidak terdapat kebermaknaan secara stastik (p=0,297) antara usia dengan kejang demam simpleks dan kompleks dan tidak terdapat kebermaknaan (p=0.787) antara jenis kelamin dengan kejang demam simpleks dan kejang demam kompleks
HUBUNGAN TINGKAT KECEMASAN DENGAN DERAJAT INSOMNIA DAN KUALITAS TIDUR
Authors: Adhaini Gusasi Indriani , Fitria Yanti , Triawanti Triawanti , Fadhilah Syaiful , Al Audhah Nelly
Published: July 2023

Kecemasan adalah perasaan yang timbul sebagai bentuk respon awal terhadap stres psikis serta ancaman terhadap nilai-nilai berarti bagi individu yang sering menghampiri dalam kehidupan sehari-hari. Kecemasan yang tidak ditangani dengan baik dapat memengaruhi mahasiswa ke arah yang buruk seperti berkurangnya kualitas tidur. Kesulitan untuk memperoleh tidur yang memadai dan telah berlangsung minimal 1 bulan disebut dengan insomnia. Kualitas tidur adalah kemampuan seseorang dalam memenuhi kebutuhan tidurnya untuk mencukupi jumlah Rapid Eye Movement dan Non Rapid Eye Movement. Penelitian ini bertujuan untuk menganalisis hubungan tingkat kecemasan dengan derajat insomnia dan kualitas tidur mahasiswa. Penelitian yang dilakukan ini adalah penelitian observasional analitik dengan pendekatan cross-sectional. Pengambilan data menggunakan data primer berupa wawancara dan pengisian kuesioner. Populasi pada penelitan ini adalah mahasiswa coass stase mayor di RSUD Ulin Banjarmasin. Jumlah sampel adalah 111 subjek penelitian dengan teknik total sampling. Hasil Uji chi square menunjukkan ada hubungan antara tingkat kecemasan dengan derajat insomnia p value = 0,000 (<0,05) dan terdapat hubungan tingkat kecemasan dengan kualitas tidur p value = 0,000 (<0,05). Berdasarkan hasil penelitian disimpulkan terdapat hubungan antara tingkat kecemasan dengan derajat insomnia dan kualitas tidur pada Program Studi Pendidikan Profesi Dokter Program Profesi pada Stase Mayor RSUD Ulin Banjarmasin.
HUBUNGAN FREKUENSI DAN JUMLAH PENGGUNAAN COTTON BUD UNTUK TOILET TELINGA TERHADAP DERAJAT KELUHAN NYERI
Authors: Larasati Anastasia , Qamariahi Nur , Rahmiati Rahmiati , Syamsuddin Alex , Hayatie Lisda
Published: July 2023

Cotton bud merupakan salah satu alat yang kerap digunakan untuk membersihkan telinga. Penggunaan cotton bud dapat mengganggu mekanisme pembersihan serumen secara alami serta dapat menyebabkan trauma dan rasa nyeri pada telinga. Tujuan penelitian ini adalah untuk mengetahui hubungan frekuensi dan jumlah penggunaan cotton bud untuk toilet telinga terhadap derajat keluhan nyeri pada telinga berdasarkan VAS. Penelitian ini menggunakan rancangan penelitian observasional analitik yang menggunakan pendekatan cross-sectional. Subjek penelitian ini adalah mahasiswa Fakultas Kedokteran Universitas Lambung Mangkurat Angkatan 2019-2021. Penelitian ini menggunakan teknik purposive sampling yang dilakukan secara daring, didapatkan sampel sebanyak 30 responden. Hasil penelitian ini adalah frekuensi dan jumlah penggunaan cotton bud yang terbanyak yakni masing-masing 1-2 kali per minggu (73,3%) dan 1-2 batang (56,7%) setiap kali toilet telinga. Hasil analisis data menggunakan uji Kolmogorov-Smirnov, dapat diambil kesimpulan bahwa tidak terdapat hubungan antara frekuensi penggunaan cotton bud (p=1,000) dan jumlah penggunaan cotton bud (p=0,670) terhadap derajat keluhan nyeri.
STUDI IN SILICO: PREDIKSI DAMPAK KOBALT DAN MERKURI TERHADAP PROTEIN PADA KEJADIAN DIABETES MELITUS
Authors: Yosephine Himawan Maria , Suhartono Eko , Fujiati Fujiati , Mashuri Mashuri , Setiawan Bambang
Published: July 2023

Kalimantan Selatan merupakan provinsi yang memiliki sumber daya alam yang melimpah khususnya di sektor pertambangan. Logam berat hasil buangan tambang batubara yang tidak diolah bersifat sangat beracun bagi lingkungan dan manusia seperti merkuri dan kobalt yang berdampak pada kesehatan manusia seperti gangguan proses glikolisis. Penelitian in bertujuan untuk mengetahui interaksi logam berat merkuri dan kobalt terhadap enzim glukokinase, 11β-hydroxysteroid dehydrogenase-1, dipeptidyl peptidase-IV, dan Interleukin-1β dengan PDB ID: 1V4S, 2BEL, 1J2E, 9ILB yang diambil dari protein data bank serta menggukan website molecular docking MIB2: Metal Ion Binding Site Prediction and Docking server. Hasil docking divisualisasikan menggunakan aplikasi Chimera versi 1.16. Ditemukan hasil dari molecular docking logam berat merkuri dan kobalt dapat berinteraksi dengan keempat protein. Ion logam merkuri berikatan secara hidrofobik dengan residu asam amino interleukin 1 β dan ikatan kovalen koordinasi glukokinase, 11β-hydroxysteroid dehydrogenase-1, dan dipeptidyl peptidase-IV. Sedangkan ion logam kobalt berikatan secara kovalen koordinasi dengan residu asam amino enzim glukokinase, 11β-hydroxysteroid dehydrogenase-1, dipeptidyl peptidase-IV, dan Interleukin-1β. Dari keempat protein, ion logam merkuri berikatan paling kuat dengan enzim dipeptidyl peptidase-IV dikarenakan dipeptidyl peptidase-IV memiliki binding potensial yang lebih kuat tetapi pada jarak ikatan ion merkuri lebih mendekati ke enzim glukokinase tersebut.