bluuebunny/crossref_metadata_2025 huggingface dataset:
Models of radionuclides behavior in "soil-plant" chain for decision support systems
Authors:   Institute of Radiobiology of the NAS of Belarus, Gomel, Nikitin A.N. , Cheshyk I.A. ,   Institute of Radiobiology of the NAS of Belarus, Gomel, Kalinichenko S.A. ,   Institute of Radiobiology of the NAS of Belarus, Gomel,   Polesye State Radiation-Ecological Reserve, Khoiniki, Shurankova O.A. ,   Institute of Radiobiology of the NAS of Belarus, Gomel
Published: September 2022

The main objectives for semi-mechanistic models enhancement are justified in the article. The "soil-plant" chain is an essential part of radioisotopes flows from nuclear accident depositions to human beings. Therefore a model which describes this system should be integrated into decision support systems for liquidation consequences of accidents with releasing radioisotopes into the environment, evaluation effectiveness of measures for radiation protection, and designing hazardous radiation facilities. Such a model must show rather exact forecast results, flexibility and wide application area convenience for practical use, and other properties. Presented now models of radionuclides behavior in "soil-plant" system divided on empiric, mechanistic, and semi-mechanistic. The empirical ones do not take into account the basic mechanisms of changes in the biological availability of radionuclides and their absorption by plants, and require constant updating and refinement of the transition parameters. Mechanistic models are of little use in real life. The last ones best meet the requirements noted above. However, substantial efforts are needed for improving their accuracy, usability, and generalization. This requires integration into data models from existing and planned sensor systems; consideration of additional factors influ-encing the transfer of radionuclides to plants; increasing the level of generalization of models with adjustment to local conditions; the use of machine learning methods to integrate information accumulated in related fields into the model; coverage of more radioactive isotopes; adding an uncertainty estimate to the simulation result; integration of models of radionuclide behavior into geoinformation systems; maintaining a sufficient level of interpretability and visibility of modeling results.
Terahertz radiation detector based on thermoelectric material Bi-=SUB=-88-=/SUB=-Sb-=SUB=-12-=/SUB=--=SUP=-*-=/SUP=-
Authors: Makarova E. S.  , Asach A. V.  , Tkhorzhevskiy I. L.  , Sedinin A. D.  , Zykov D. V.  , Zaitsev A. D.  , Demchenko P.  , Novoselov M. G.  , Komarov V. A.  , Tukmakova A. S.  , Novotelnova A.V.  , Kablukova N. S.  , Khodzitsky M.K.
Published: September 2022

Terahertz radiation is very promising for visualization, detection and data transfer. Searching for sensitive, fast and compact THz detector that operates at room temperature is a common subject for these applications. Hence, there is still an issue of searching for new materials for THz radiation detection. Solid solutions based on thermoelectric bismuth and antimony appear to have significant potential for these applications. In this paper photoresponse of thermoelectric material Bi88Sb12 has been studied for the first time. Films with thicknesses of 70 and 150 nm were studied under influence of radiation at frequency of 0.14 THz. Keywords: terahertz radiation, photoresponse, bismuth, antimony, thermoelectric materials, thin films.
Plasmon spectroscopy of anisotropic gold nanoclusters on GaAs(001) surface passivated by sulphur atoms
Authors: Berkovits V. L.  , Kosobukin V. A.  , Ulin V. P.  , Alekseev  P. A.  , Soldatenkov F. Yu.  , Levitskii V.A.
Published: September 2022

This work demonstrates how to create the structures Au/GaAs with perfect on-surface gold nanoclusters. In doing so, used is covering the GaAs substrate with chemically stable atomic monolayers of sulphur to prevent subsequently a chemical reaction of Au with GaAs. The structures Au/S/GaAs with monolayers of chemisorbed sulphur atoms are fabricated, characterized and studied by polarized reflection spectroscopy. The anisotropy of on-surface gold nanoclusters is established, and the anisotropic plasmons localized in Au clusters are investigated using the spectra of polarized reflection and interpreted theoretically. Keywords: sulphide passivation, gold nanoclusters, plasmon anisotropy, polarized reflectance.
Current Transfer in a Semiconductor Structure with a Porous Silicon Film formed by Metal-Stimulated Etching
Authors: Melnik N. N.  , Tregulov V. V.  , Litvinov V. G.  , Ermachikhin A. V.  , Trusov E. P.  , Skoptsova G. N.  , Ivanov A. I.
Published: September 2022

It is shown that during a porous Si film formation by metal-stimulated etching a barrier layer is formed on a monocrystal p-Si substrate. The rectifying properties of the semiconductor structure can be explained by the fixation of the Fermi level in the near-surface layer of porous Si due to a high concentration of electrically active defects (deep centers or traps). It causes to energy bands bending and the appearance of a potential barrier. The study of Raman scattering showed the absence of size effects and a change in the band gap in the porous Si film. Activation energies of deep centers by the temperature dependence of the current-voltage characteristics and deep level transient spectroscopy study were determined. Keywords: porous silicon, deep level, Raman scattering, current-voltage characteristics, deep level transient spectroscopy.
Investigation of van der Waals crystals of GaSe and GaS-=SUB=-x-=/SUB=-Se-=SUB=-1-x-=/SUB=- by photoreflectance method
Authors: Khakhulin S. A.  , Kokh K. A.  , Komkov O. S.
Published: September 2022

Photoreflectance spectra of layered undoped GaSe and GaSxSe1-x crystals present Franz--Keldysh oscillations indicating the near-surface built-in electric field, that can participate in the separation of photoinduced charge carriers in ultrahigh-sensitive photodetectors based on these materials. The measured value of the field strength in GaSxSe1-x turned out to be almost 1.5 times less than in GaSe, that may indicate a smaller number of free charge carriers in the solid solution. The broadening parameter of GaSxSe1-x spectral lines is also significantly lower than in the case of GaSe. This is due to the fact that isovalent atoms, being added into the GaSe, fill Ga vacancies, reducing the number of defects and the concentration of intrinsic charge carriers. The high-field modulation mode observed in the photoreflectance spectrum of GaSxSe1-x doped with an Al donor impurity indicates a relatively small thickness of the depletion region due to the presence of a large number of free electrons. Keywords: photoreflectance, Franz--Keldysh oscillations, GaSe, gallium monoselenide, van der Waals crystals, layered crystals.
Comparative study of photocells based on silicon doped with nickel by various methods
Authors: Ismailov K. A.  , Zikrillaev N. F.  , Koveshnikov S. V.  , Kosbergenov E. Zh.
Published: September 2022

In this work, the parameters of silicon-based photocells doped with impurity nickel atoms by diffusion methods and during growth were compared. It was found that photocells doped with impurity nickel atoms during silicon growth have an improvement in parameters comparable to that obtained by the diffusion doping method. Additional heat treatment at T=800oC makes it possible to significantly improve their basic parameters. Keywords:silicon, photocell, nickel, thermal annealing, diffusion.
mHealth-Supported Gender- and Culturally Sensitive Weight Loss Intervention for Hispanic Men With Overweight and Obesity: Single-Arm Pilot Study
Authors: Garcia David O , Valdez Luis A , Aceves Benjamin , Bell Melanie L , Rabe Brooke A , Villavicencio Edgar A , Marrero David G , Melton Forest , Hooker Steven P
Published: September 2022

Background

Hispanic men have disproportionate rates of overweight and obesity compared with other racial and ethnic subpopulations. However, few weight loss interventions have been developed specifically for this high-risk group. Furthermore, the use of mobile health (mHealth) technologies to support lifestyle behavior changes in weight loss interventions for Hispanic men is largely untested.

Objective

This single-arm pilot study examined the feasibility and acceptability of integrating mHealth technology into a 12-week gender- and culturally sensitive weight loss intervention (GCSWLI) for Hispanic men with overweight and obesity.

Methods

A total of 18 Hispanic men (mean age 38, SD 10.9 years; mean BMI 34.3, SD 5.5 kg/m²; 10/18, 56% Spanish monolingual) received a GCSWLI, including weekly in-person individual sessions, a daily calorie goal, and prescription of ≥225 minutes of moderate-intensity physical activity per week. mHealth technology support included tailored SMS text messaging, behavior self-monitoring support using Fitbit Charge 2, and weight tracking using a Fitbit Aria Wi-Fi Smart Scale. Changes in weight from baseline to 12 weeks were estimated using a paired 2-tailed t test. Descriptive analyses characterized the use of Fitbit and smart scales. Semistructured interviews were conducted immediately after intervention to assess the participants’ weight loss experiences and perspectives on mHealth technologies.

Results

Of 18 participants, 16 (89%) completed the 12-week assessments; the overall attrition rate was 11.1%. The mean weight loss at week 12 was −4.7 kg (95% CI 7.1 to −2.4 kg; P<.001). Participants wore the Fitbit 71.58% (962/1344) of the intervention days and logged their body weight using the smart scale (410/1344, 30.51% of the intervention days). Participants identified barriers to the use of the technology, such as lack of technological literacy and unreliable internet access for the smart scale.

Conclusions

Although clinically significant weight loss was achieved by integrating mHealth technology into the GCSWLI, adherence to the prescribed use of technology was modest. Addressing barriers to the use of such technologies identified in our work may help to refine an mHealth intervention approach for Hispanic men.

Trial Registration

ClinicalTrials.gov NCT02783521; https://clinicaltrials.gov/ct2/show/NCT02783521
Sustainability of Weight Loss Through Smartphone Apps: Systematic Review and Meta-analysis on Anthropometric, Metabolic, and Dietary Outcomes
Authors: Chew Han Shi Jocelyn , Koh Wee Ling , Ng Janelle Shaina Hui Yi , Tan Ker Kan
Published: September 2022

Background

Evidence on the long-term effects of weight management smartphone apps on various weight-related outcomes remains scarce.

Objective

In this review, we aimed to examine the effects of smartphone apps on anthropometric, metabolic, and dietary outcomes at various time points.

Methods

Articles published from database inception to March 10, 2022 were searched, from 7 databases (Embase, CINAHL, PubMed, PsycINFO, Cochrane Library, Scopus, and Web of Science) using forward and backward citation tracking. All randomized controlled trials that reported weight change as an outcome in adults with overweight and obesity were included. We performed separate meta-analyses using random effects models for weight, waist circumference, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood glucose level, blood pressure, and total energy intake per day. Methodological quality was assessed using the Cochrane Risk of Bias tool.

Results

Based on our meta-analyses, weight loss was sustained between 3 and 12 months, with a peak of 2.18 kg at 3 months that tapered down to 1.63 kg at 12 months. We did not find significant benefits of weight loss on the secondary outcomes examined, except for a slight improvement in systolic blood pressure at 3 months. Most of the included studies covered app-based interventions that comprised of components beyond food logging, such as real-time diet and exercise self-monitoring, personalized and remote progress tracking, timely feedback provision, smart devices that synchronized activity and weight data to smartphones, and libraries of diet and physical activity ideas.

Conclusions

Smartphone weight loss apps are effective in initiating and sustaining weight loss between 3 and 12 months, but their effects are minimal in their current states. Future studies could consider the various aspects of the socioecological model. Conversational and dialectic components that simulate health coaches could be useful to enhance user engagement and outcome effectiveness.

Trial Registration

International Prospective Register of Systematic Reviews (PROSPERO) CRD42022329197; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=329197
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ACLIDINIUM BROMIDE AND FORMOTEROL FUMARATE IN BULK AND INHALER FORMULATION
Authors: LAKSHMI A. JAYA , ABHISHEK K. , PRIYANKA Y. LEELA , BALAJI P. V. , ASHRITHA N.
Published: September 2022

Objective: To develop a simple, accurate, precise, rapid and sensitive method for the simultaneous estimation of Formoterol fumarate and Aclidinium bromide in pharmaceutical dosage form.

Methods: The chromatogram was run through Ascentis C18 150 x 4.6 mm, 5µ. Mobile phase containing Water: Acetonitrile taken in the ratio 60:40 was pumped through the column at a flow rate of 1.0 ml/min. The temperature was maintained at 30 °C. The optimized wavelength selected was 220 nm.

Results: The retention times of Formoterol fumarate and Aclidinium bromide were found to be 2.953 min and 2.364 min. %RSD of the Aclidinium bromide and Formoterol fumarate was found to be 0.6 and 0.9, respectively. %Recovery was obtained as 99.81 % and 100.20% for Aclidinium bromide and Formoterol fumarate, respectively. LOD, LOQ values obtained from the Signal-to-noise ratio of Aclidinium bromide and Formoterol fumarate were 0.84 µg/ml, 2.56 µg/ml and 0.01 µg/ml, 0.03µg/ml respectively. Regression equation of Formoterol fumarate is y =9023x+268.67, and y = 4661.2x+1941.9 of Aclidinium bromide. Retention times were decreased and that run time was decreased, so the method developed was simple, rapid, sensitive and economical that can be adopted in regular quality control tests in Industries.

Conclusion: Developed and Validated Formoterol fumarate and Aclidinium bromide in pharmaceutical dosage form by using RP-HPLC method.
NEW FTIR METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ANALYSIS OF FAVIPIRAVIR IN BULK AND PHARMACEUTICAL DOSAGE FORMS
Authors: P. NITHILA , RAGHAVENDRABABU N. , PADMAVATHI Y. , NEENA G. , SUSHMA K. , POOJITHA A.
Published: September 2022

Objective: A simple spectrophotometric method has been proposed for quantitative analysis of favipiravir in bulk and pharmaceutical dosage form.

Methods: New Fourier transform infrared (FTIR) spectroscopic method has been developed for the estimation of favipiravir by using solid pellet technique.

Results: Results were linear over the 20–100µg/mg concentration range, with correlation values exceeding 0.999. The approach was thoroughly validated in accordance with the recommendations of the International Conference on Harmonization, demonstrating acceptable levels of accuracy, precision, selectivity, robustness, and linearity.

Conclusion: The statistical comparison between this method and HPLC revealed that the newly developed method was significantly distinct. Thus, it proves to be applicable. It met all validation standards over a variety of concentrations and can be used as a substitute for the official procedures.
A REVIEW ON ADVANCES IN PHARMACEUTICAL CO-CRYSTAL PREPARATION ROUTES, INTELLECTUAL PROPERTY PERSPECTIVE AND REGULATORY ASPECTS
Authors: SARAF GANESH J. , BURADE KISHOR KUMAR B. , GONJARI INDRAJEET. D , HOSMANI AVINASH H. , PAWAR ARTI A.
Published: September 2022

As in recent years, due to the pervasiveness of poorly soluble APIs that demonstrates poor and erratic bioavailability, pharmaceutical cocrystal’s applicability to tailor the physicochemical properties has gained attention. Pharmaceutical cocrystal has been an exciting field of interest to researchers as this encouraged several regulatory bodies to create regulatory standards, which led to the approval of these crystals for marketing in various nations. With the upsurge in the growth of pharmaceutical cocrystals, the major concern is over the intellectual property perspective and regulatory status of cocrystals. With the new guidelines from the United States Food and Drug Administration (USFDA) and European Medicines Agency (EMA), the manufacturing and characterization of cocrystal have become less complicated. In this article, various preparation routes are mentioned along with this intellectual property perspective and regulatory perspective, including regulatory guidelines, which give an idea of whether cocrystals meet the criteria for patent eligibility and how they would change the current state of the pharmaceutical industry. Here, we also reviewed some recently approved patients on pharmaceutical crystals, which provided benefits over poor physicochemical property of drug substances and also enhanced the therapeutic effectiveness of that drugs.
ИССЛЕДОВАНИЕ ЧЕРНИЛ ДЛЯ 3D-ПЕЧАТИ ЭЛЕКТРОНИКИ: ВЫБОР ТЕХНОЛОГИЙ
Authors: Горелов А.
Published: September 2022

Описан начальный этап исследований по созданию прототипа отечественной технологии 3D-печати печатных плат, ведущихся в МАИ по госзаданию от Министерства науки и высшего образования РФ. За основу взята технология струйной печати PolyJet, задачей начального этапа является разработка методики получения проводящих чернил из производимых в России исходных материалов.
НАДО НАУЧИТЬСЯ В ЭТО НЕПРОСТОЕ ВРЕМЯ СООБЩА РЕШАТЬ ОБЩИЕ ЗАДАЧИ
Authors: Кондрашов З.
Published: September 2022

За последнее время произошли существенные
изменения обстановки, которые в значительной
мере сказались на отечественной электронной
и радиоэлектронной промышленности.
Предприятиям пришлось искать новых
технологических партнеров, перестраивать
логистические цепочки, искать замену
технологиям, доступ к которым оказался
ограничен. В то же время новые условия
открывают и новые возможности для российских
разработчиков и производителей электроники.
Захар Константинович Кондрашов, генеральный
директор АО «НИИМА «Прогресс» – одного
из ведущих российских дизайн-центров
в области ЭКБ и разработчиков электронной
аппаратуры в таких актуальных областях, как
связь и навигация, рассказал нам о том, какие
сейчас стоят задачи перед институтом, как на его
деятельность повлияла изменившаяся ситуация,
а также поделился своим видением того, что
необходимо для развития отрасли в целом.
Комплекс методов оптико-спектрального анализа для установления целевой химической чистоты соединений редкоземельных металлов и материалов на их основе
Authors: Барановская В.Б. , Петрова К.В. , Доронина М.С. , Кошель Е.С. , Короткова Н.А. , Архипенко А.А.
Published: September 2022

Исследование и разработка материалов на основе редкоземельных металлов востребованы и перспективны для микроэлектроники, оптической связи, лазерных технологий и др. Важным требованием для их эффективного применения являются химическая чистота и прогнозируемый состав исходных веществ. Установление чистоты исходных РЗМ и их соединений, контроль состава промежуточных и конечных продуктов представляют собой сложную аналитическую задачу. Cозданы комплексные методики анализа магнитных, люминофорных и оптических материалов и исходных веществ для их получения методами атомно-­эмиссионной спектрометрии с индуктивно связанной плазмой, масс-спектрометрии с индуктивно связанной плазмой и дугового атомно-­эмиссионного анализа . Комплексное взаимодополняющее применение этих методов обеспечивает высокую точность и достоверность результатов, расширяет границы определяемых содержаний целевых примесей, перечень аналитов и номенклатуру анализируемых материалов.
Formulation and In- Vitro Evaluation of Baclofen Gastroretentive Microballoons for Sustained Drug Delivery
Authors: Gomathi J. , Muthukumaran T. , C Kavitha. , Sinha Priyanka , Balla Sabbathyan
Published: September 2022

Abstract: A sustained release drug delivery system for baclofen was designed to increase its residence time in the stomach without establishing contact with the mucosa. This was made possible through the preparation of microballoons by emulsion solvent diffusion-evaporation technique. The prepared microballoons were characterized for physical characteristics such as particle size, particle shape and surface morphology by scanning electron microscopy. Further, percentage yield determination, drug entrapment efficiency, in vitro buoyancy test, micromeritic investigations and in vitro drug release studies were carried out. The obtained microspheres were free flowing, spherical and displayed a particle size ranging from 50.15 to 67.0µm suitable for oral delivery. The drug entrapped in the hollow microspheres increased with the increase in eudragit RSPO content. Scanning electron microscopy and particle size analysis revealed differences in the formulations in respect to their appearance and size distribution. The FTIR spectroscopy technique and DSC were carried out to rule out drug – excipients interactions. From the results obtained, it was concluded that there was no interaction between drug and the excipients. The formulation containing Baclofen:Eudragit RSPO (1:3 and 1:4) exhibited higher percentage values for buoyancy time. The drug release was found to follow Higuchi kinetics with non-fickian diffusion mechanism, from all the four batches. These preliminary results indicate that baclofen loaded microballoons could be effective in sustaining drug release for prolonged periods of time
Benchmarking the Planar Honeycomb Code
Authors: Gidney Craig , Newman Michael , McEwen Matt
Published: September 2022

We improve the planar honeycomb code by describing boundaries that need no additional physical connectivity, and by optimizing the shape of the qubit patch. We then benchmark the code using Monte Carlo sampling to estimate logical error rates and derive metrics including thresholds, lambdas, and teraquop qubit counts. We determine that the planar honeycomb code can create a logical qubit with one-in-a-trillion logical error rates using 7000 physical qubits at a 0.1% gate-level error rate (or 900 physical qubits given native two-qubit parity measurements). Our results cement the honeycomb code as a promising candidate for two-dimensional qubit architectures with sparse connectivity.
Teaching Self-directed Learning Skills Through a Resident-Led Milestones Process
Authors: Fortenberry Katherine T. , Cochella Susan , Stoesser Kirsten , Ose Dominik , Taylor Eliza , Frame Kara A. , Van Hala Sonja
Published: September 2022

Introduction: The Accreditation Council for Graduate Medical Education allows flexibility for resident roles in the Milestone assessment process. The University of Utah Family Medicine Residency implemented a resident-led Milestones process to cultivate the skill of self-assessment and promote resident ownership of their learning.
Methods: Residents were provided comprehensive evaluation data and asked to self-assess their competency on each Milestone, with input from their advisor. Residents presented their self-assessment to the Clinical Competency Committee, who then determined the final score for each Milestone. A 10-question survey examined perceptions of the resident-led Milestones process by residents and faculty. We calculated means and standard deviations (SD).
Results: A total of 16 of 24 residents (67% response rate) and 12 of 14 faculty (86% response rate) completed the survey. Residents agreed most highly with the following statements: “I have good support from my advisor in being prepared to lead my Milestones meeting,” “I am actively engaged in guiding the development of my own Milestones ratings,” and “Leading my Milestones meeting assists me in accurately self-assessing my progress.” Residents showed high agreement that “My final Milestones scores accurately reflect my behavior and level of knowledge.” Residents rated the stress as low, in response to the statement, “My Milestones meeting is stressful for me.” Faculty responses were similar but tended toward lower scores than residents.
Conclusion: The resident-led Milestones process engages residents actively in self-assessment. Residents and faculty believe the process provides accurate assessment results without undue stress; this process potentially increases residents’ ability to understand their own learning needs and direct their own learning process.
Renal vein thrombosis after COVID-19, A case report Dr. Vida Shirzadeh (Corresponding Author); Ardabil University of Medical Sciences, Faculty of medicine, Emam Khomeini hospital, Ardabil, Iran Email: vidashsh95@gmail.com
Authors: Roudsari Hamid Janbazi , Negaresh Mohammad , Shirzadeh Vida , Germi Bahman Mohammadzadeh , Mirzaei Arezoo
Published: September 2022

COVID-19 can lead to pneumonia or acute respiratory distress syndrome.
Non-respiratory manifestations of COVID-19 include venous and arterial
thrombosis. The disease can affect kidneys and lead to renal vein
thrombosis leading to symptoms such as flank pain, hematuria, or acute
kidney damage.
Pulsed-field ablation for the treatment of left atrial reentry tachycardia
Authors: Küffer Thomas , Seiler Jens , Madaffari Antonio , Mühl Aline , Asatryan Babken , Stettler Robin , Haeberlin Andreas , Noti Fabian , Servatius Helge , Tanner Hildegard , Baldinger Samuel , Reichlin Tobias , Roten Laurent
Published: September 2022

Aims A multipolar pulsed-field ablation (PFA) catheter was
recently introduced for pulmonary vein isolation and shows great promise
with respect to procedural efficacy and safety. We describe our initial
experience using this multipolar PFA catheter for the treatment of left
atrial (LA) reentry tachycardia. Methods We included all
patients with LA reentry tachycardia treated with PFA at our institution
between September 2021 and March 2022. The tachycardia mechanism was
identified using 3D electro-anatomical mapping (3D-EAM). Subsequently, a
roof line, anterior line, or mitral isthmus line was ablated as
appropriate. Roof line ablation was always combined with LA posterior
wall (LAPW) isolation. Supplementary ablation of a roof- or anterior
line was added in patients with extensive low-voltage areas to avoid
future arrhythmias. Positioning of the PFA catheter was guided by a
3D-EAM system, and by fluoroscopy. Bidirectional block across lines was
verified using standard criteria. Additional focal radiofrequency
ablation (RFA) was used to achieve bidirectional block as necessary.
Results Among 22 patients (median age 70 (59-75) years; 9
females), we identified 27 LA reentry tachycardia: Seven roof dependent
macro-reentries, one micro-reentry located on the posterior wall, twelve
peri-mitral macro-reentries, and seven micro-reentries located on the
anterior wall. We ablated a total of 20 roof lines, 13 anterior lines
and 6 mitral isthmus lines. Additional RFA was necessary for two
anterior lines (15%) and three mitral isthmus lines (50%).
Bidirectional block was achieved across all roof lines, 92% of anterior
lines and 83% of mitral isthmus lines. We observed no acute procedural
complications. Conclusion Ablation of a roof line and LAPW
isolation is feasible, effective and safe using this multipolar PFA
catheter. However, the catheter is less suited for ablation of the
mitral isthmus and the anterior line. A focal pulsed-field ablation
catheter may be more effective for ablation of these lines.
CHARACTERIZATION OF DIFFERENTIAL EXPRESSION PATTERNS OF THE EXTRACELLULAR PURINERGIC ENZYMES IN COLORECTAL CANCER
Authors: GÖKTUNA Serkan
Published: September 2022

The aim of this study is to characterize tumor cell specific expression of purinergic ecto-enzymes CD39 and CD73, and to associate prognostic significance of these expression patterns in colorectal cancer (CRC) patients. Protein and gene expression of the target genes in various CRC cell lines were assessed via Western Blot (WB) analysis and Real Time PCR (RT-PCR). Additionally, tumor vs stromal cell expression of the target genes was analyzed from publicly available patient expression datasets. Finally, the correlation between CD39 and CD73 expression with patient prognosis was analyzed via The Cancer Genome Atlas (TCGA) datasets. In CRC cell lines, CD39 was found to be not expressed at all while CD73 was expressed extensively in most cell lines via WB and RT-PCR analyses. Patient microarray expression data confirmed the results from CRC cell lines that CD39 expression was very low in epithelial/tumor cells relative to other stromal cell types yet CD73 was expressed abundantly in every cell type within patient tumor samples. Interestingly, CD39 expression in patient tumors was correlated with favorable prognosis while CD73 expression was associated with worse prognosis. Although CD39 and CD73 are related enzymes involved in extracellular purinergic signaling, their expression patterns in tumor cells and prognostic effects in patients show opposing outcomes. Therefore, better insights in understanding the functional involvement of purinergic ecto-enzymes in colorectal tumor development is needed via further mechanistic studies.
Peningkatan Minat dan Hasil Belajar Matematika Siswa SMK Menggunakan Model PBL
Authors: Arifin Mochammad , Faiziyah Nuqthy , Wahyuningsih Eni Astuti
Published: September 2022

This research is motivated by the interest in learning of SMK Taman Karya Madya Pertambangan Kebumen students which are classified as low criteria with an average of 37.5%. Meanwhile, students' mathematics learning outcomes are also still unsatisfactory, with no students who complete with an average score of 58.33. Based on the problems above with Power Point (PPT) media. in increasing interest and learning outcomes of mathematics in linear program material for students of Class X SMK Taman Karya Madya Pertambangan Kebumen. 12 children as subjects and carried. Showed that interest in learning increased from the pre-cycle results from the low category with an average of 37.5% to the medium category with an average of 63.02%. Furthermore, in the implementation in cycle 2, interest in learning again increased to the high category with an average of an average of 77.60%. Likewise, the percentage of students who completed the learning outcomes test increased from the pre-cycle results to an average of 58.33 to 73.75 and in the second cycle increased to 80.83. Likewise, the percentage of students who completed the mathematics learning outcomes test increased to 83.33%.
Penerapan Model PBL Berbasis PPT Berbantuan Soal Cerita untuk Meningkatkan Minat dan Hasil Belajar Siswa
Authors: Wusananto Trio , Faiziyah Nuqthy , Wahyuningsih Eni Astuti
Published: September 2022

This Classroom Action Research (CAR) aims to increase students' interest and learning outcomes in mathematics at SMK Bhakti Praja Margasari by applying problem-based learning (PBL) techniques. This research uses problem-based learning about story questions that other researchers have rarely done before. This research was conducted by adapting the Kemmis and McTaggart model into four stages: planning, implementation, observation, and consideration. A total of 32 students of class XAKL 1 SMK Bhakti Praja Margasai were used as the subjects of this study. Three tools were used to collect data: a questionnaire, an observation sheet, and a test. Learning outcomes data were analyzed quantitatively, while interest and practice data were analyzed qualitatively. The analysis showed that the students' interest in mathematics and their learning outcomes increased from the initial state. At the end of the second cycle, the PBL learning method met the objectives/ criteria for success. This means that 75% of students have reached the KKM. Students' interest in learning also meets the goals/criteria for indicators of success. This means that 78.13% of students are interested in learning in the "very high" category and 18.75% of students are interested in learning in the "high" category. Some conclusions from this CAR are: First, after a two-action cycle, the PBL method was proven to increase interest in learning and learning outcomes for students of class X AKLI 1 SMK Bhakti Praja Margasari. Second, the growth of student interest in learning is appreciated by the active role of students through the use of PBL. Third, presenting mathematical problems through narrative questions that are close to the context of students' daily lives, thus facilitating understanding of abstract mathematical concepts and increasing not only student interest but also learning outcomes. Fourth, the success of PBL implementation is highly dependent on the consistency of the teacher acting as a facilitator. The results of this study provide empirical evidence about the importance of planning, monitoring, and improving CAR-based learning.
Pemanfaatan Media Sosial Instagram sebagai Media Promosi untuk Meningkatkan Engagement Pada Kedai Bintoro Kopi
Authors: Novianto  , Y H Suprianto  , R A P Singgih  , Jonathan  , A H Gunadi  , Y P Wibisono
Published: September 2022

Perkembangan teknologi berkembang sangat pesat dalam beberapa tahun belakangan ini terutama pada media sosial. Salah satu media sosial yang paling banyak digunakan adalah Instagram. Biasanya Instagram digunakan untuk media promosi para pemilik bisnis, baik perusahaan maupun UKM.  Salah satu UKM yang menggunakan Instagram sebagai media promosi adalah Kedai Kopi Binkop. Akan tetapi promosi Binkop masih kurang maksimal dari segi desain dan konsistensi. Untuk mengatasi masalah tersebut, diperlukan pelatihan dalam penggunaan media sosial untuk promosi. Pelatihan dilaksanakan sebanyak lima sesi yaitu pelatihan teori desain dan marketing, pelatihan pengaplikasian dan tiga sesi pendampingan. Dari pelatihan ini kedai Kopi Binkop menghasilkan tiga unggahan IG Story dan empat IG Feed. Terlihat dari statistik Insight Instagram Binkop bahwa terdapat kenaikan yang signifikan pada akun yang dijangkau dan akun yang berinteraksi setelah diadakannya pelatihan.
Pengembangan Pembelajaran Bahasa Indonesia Kelas IX di SMPN 4 Pasar Kemis dengan Menggunakan Powtoon
Authors: L C Budikusuma  , H R Putranto  , I P Indraswara  , A V P Wibowo  , E Marsella
Published: September 2022

Pengabdian masyarakat ini dilakukan untuk mengatasi permasalahan para pengajar di sekolah SMPN 4 Pasar Kemis yang khusus diberikan pada kelas IX untuk mempermudah pendalaman ilmu pada pelajaran Bahasa Indonesia yang saat ini sedang menjalani pembelajaran jarak jauh atau disebut dengan pembelajaran dalam jaringan. Maka dari itu dalam mengatasi permasalahan tersebut, dibutuhkan sebuah pemanfaatan multimedia interaktif dengan memberikan sebuah video pembelajaran yang dibuat menggunakan sarana powtoon untuk menunjang pembawaan materi yang sudah berkoordinasi oleh tim pengajar pada mata pelajaran ini. Dengan adanya video pembelajaran ini diharapkan dapat membantu para siswa-siswinya dalam memahami materi yang ada, juga memudahkan pengajaran guru ketika menjelaskan materi yang diberikan oleh mereka. Kedepannya para guru bisa menggunakan metode yang dibuat ini untuk menunjang pengajaran mereka.
Spiritualitas Keluarga Katolik di Era Disrupsi Teknologi
Authors: C Suryanti  , E Marsella
Published: September 2022

Penelitian ini meneliti hakikat keluarga menurut ajaran Katolik. Ia menemukan bahwa jati diri keluarga kristiani adalah Gereja rumah tangga (ecclesia domestica). Keluarga adalah pusat pertumbuhan iman setiap anggota keluarga. Tidak hanya orang tua, anak-anak yang tumbuh dalam keluarga katolik mesti menimba semangat dasar dari hidup dan meneladani karya Yesus dalam mewartakan Kerajaan Allah. Sebagai Gereja rumah tangga, keluarga mengambil bagian dalam tiga tugas Kristus, yaitu sebagai imam, raja, dan nabi. Kehidupan sehari-hari dalam keluarga menjadi tempat yang kondusif dan efektif bagi perwujudan tiga tugas tersebut. Keluarga merupakan tempat yang tepat untuk perayaan iman bersama, untuk pewartaan iman, dan mewujudkan persaudaraan dalam kasih. Penemuan ini sangat relevan saat ini di mana teknologi telah mendisrupsi banyak peranan keluarga. Pembinaan iman yang semula dapat dilaksanakan oleh pelbagai persekutuan di paroki, pada saat pandemi covid 19 harus dilaksanakan oleh keluarga. Keluarga modern telah terdampak perkembangan teknologi yang cepat sehingga mempengaruhi pola hidup mereka. Banyak keluarga yang tetap berpegang pada nilai-nilai dasar kehidupan berkeluarga, tetapi banyak juga keluarga yang bimbang dan bingung tentang peranan keluarga dalam dunia modern. Penelitian ini menerapkan pendekatan penelitian kualitatif. Data penelitian diambil dari pelbagai sumber kepustakaan yang dianalisis secara deskriptif dan analitis. Pada akhirnya peneliti mengambil kesimpulan dari analisis tersebut.
Carotid endarterectomy: A case study and literature review
Authors: Tabane Tebogo , Oosthuizen Alexis
Published: September 2022

Carotid endarterectomy (CEA) is a preventative surgery that is performed in patient populations at risk of emboli due to an atherosclerotic plaque, located at the carotid bifurcation. Despite the advances in overall treatment, no consensus has been reached on the preferred anaesthetic for CEA. Improved procedural outcomes are due to the advances in medical therapy, cerebral monitoring, improved timing of surgery with improved surgical techniques and the use of ultrasound guided regional techniques. However, the choice of anaesthetic should consider the patient, the hospital’s resources and the preferences of the anaesthesiologist and surgeon.
A canção folclórica em sua essência: uma análise etnomusicológica de duas canções populares tradicionais brasileiras
Authors: Vaccari Pedro Razzante
Published: September 2022

Investigou-se as origens e procedências principais de duas canções populares tradicionais brasileiras, a saber: o canto de Maracatu “Loanda” e a canção indígena “Natiô”, dos Paresis. Elas representam um panorama estilístico da música popular brasileira, seja ela urbana, rural ou feita pelos próprios nativos. Guardam, portanto, além de idiossincrasias de ordem estético-musical, características próprias de cada região e grupo étnico que as produziram. São fonte cultural que espelham a enorme profusão de cantos que o país continental produzira até os anos 1930, quando eclodiu no Brasil o Movimento Nacionalista, que buscava unificar as linguagens da Literatura, Música e Artes Plásticas em prol de uma totalidade artística que desvelasse os significados de Nacionalidade. As canções em questão foram reunidas e harmonizadas pelo compositor paraibano José Siqueira (1907-1985), e lançadas em disco em 1939. Nelas podemos ver retratos de diversos matizes do colorido nacional: música popular rural percussiva, ritualística indígena e religiosa afro-brasileira. Constituem peças de um quadro maior, onde podem ser observadas as diversas regiões brasileiras, num jogo etnomusicológico que parece querer traduzir a essência folclórica do nosso povo.
Análise da crítica aos costumes orientais na ótica do cristianismo primitivo através do apócrifo Atos de Tomé
Authors: Costa Otávio Barduzzi Rodrigues da
Published: September 2022

Este trabalho trata da análise do livro apócrifo cujo texto integral se encontra traduzido do siríaco para o inglês na obra The Apocryphal Acts of Thomas, do autor Jan N. Bremmer, publicado em 2001, ainda sem tradução para o português. Evidentemente não há como tratar desse assunto sem analisar o próprio escrito apócrifo Atos de Tomé (ATh). Pretende-se, nesta breve análise, descrever as considerações de um dos grandes estudiosos sobre apócrifos, cristianismo primitivo e a obra tomasina, a saber, Jan N. Bremmer e seus convidados. Outrossim, recomenda-se a todos a leitura desta análise.
FORMING STUDENT CHARACTER THROUGH THE ISLAMIC BOARDING SCHOOL PROGRAMS AT SMP-IT TARBIYATU BANIN DUKUHPUNTANG CIREBON
Authors: Muthoharoh Muthoharoh , Elvina Inez
Published: September 2022

Education is an effort to shape students' characters, one of which is to develop students who are independent, cooperative, tolerant, and critical thinkers. The purpose of this qualitative descriptive study is to collect data on the process and application of character education, as well as data about the difficulties that teachers face when implementing character education in Islamic boarding schools. This study included several respondents, including Islamic boarding school supervisors, school principals, teachers, and eighth grade students. Interviews, observation, and documentation were used to obtain and collect data on character education in Islamic boarding schools. The results of this research demonstrate that character education at the Islamic Boarding School Tarbiyatul Banin Dukuntang Cirebon is consistent with national education goals, namely character formation. According to the data, the character education implemented at Tarbiyatul Banin Integrated Islamic Junior High School, Dukupuntang, Cirebon uses the implementation of programs provided at schools and also at boarding schools such as the dhuha prayer program, fardhu prayer in congregation, tahajjud prayer, and dhikr in the form of istighfar to build the students' religious character. extracurricular activities, cults to develop student leadership and self-confidence, programs such as Qur'an translation, Tahfidz, and book recitation to explore religious knowledge.
A Review on Time and Cost Issues of Infrastructure Projects
Authors:   Institute of Business Management, Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India, Mishra Anjay Kumar
Published: September 2022

The research is a review research conducted on the issues of time and cost performance of infrastructure projects in global and local context using content analysis. Time extension is a serious issue and further research for specific project should be conducted to search the effective measures in the area. During project based study the quality part should be assured as time and cost may be affected by or can affect quality of the project. The review has highlighted several factors affecting time overrun and cost overrun along with the relation between the same. Time, Cost and Quality are three sides of a project performance triangle. Project is one time unique process with specific objective which is source of innovation and development. Time extension is not an exception but norms for infrastructure projects should be verified through ecological testing and possible measures should be strongly enforced for systematic performance improvements of projects. The study will be significant for policy maker and professional project managers working in the sector of infrastructure development projects.
Assessment on Diarrhoea and its Herbal Remedy with Ficus Tree
Authors:   MPharm (Pharmacology), Saraswati Higher Education and Technical College of Pharmacy, Varanasi, Uttar Pradesh, India, Sharma Sonali
Published: September 2022

Diarrhoea is defined as an abnormal frequent discharge from the bowel (more than 3 times a day) and a semisolid or fluid consistency of the faecal matter which is result of the disturbances of enteric water, electrolytes balance and increased intestinal motility. There is a wide array of causes and pathological mechanism which resulting acute, chronic and persistent forms of diarrhoea. In present scenario, corona virus has also become one of the causes for resulting diarrhoea. To treat diarrhoea, varieties of synthetic drugs are available but there is a risk of unwanted adverse effect. Expenses associated with the use of traditional medicine have generated recommence interest and reliance on indigenous medicinal plant in the treatment and management of diarrhoeal infections. Various phytochemical constituents found in plants are useful in the treatment of Diarrhoea have to be screen for their valuable information. Among these one of the plants used for treatment of Diarrhoea is Ficus glomerata because of the presence of Alkaloids, Tannins, Flavonoids, Terpenes, Saponins and Phenolic compound.
RELIABILITY OF FUNCTIONAL COMPRESSIVE BANDAGING IN THE TREATMENT OF LYMPHEDEMA SECONDARY TO THE TREATMENT OF BREAST CANCER
Authors: Apolinário A. , Kohl Lima É.L. , Borsari G.C. , Rezende M.S. , Rangon F.B. , Rossi D.M. , de Oliveira Guirro E.C.
Published: September 2022

Functional compressive bandaging (FCB) is a therapeutic resource used to control lymphedema resulting from the treatment of breast cancer. However, the reliability of the technique is unknown. We evaluated intra- and inter-rater reliability of the spiral technique in the four-layer FCB of the arm and forearm in breast cancer survivors with lymphedema. Forty-five breast cancer survivors with a mean age of 64.88±10.01 years participated in the study. Evaluations were performed by two examiners at different times analyzing the pressure exerted (mmHg) by the spiral FCB in the arm and forearm of the upper limb affected by lymphedema. The intraclass correlation coefficient (ICC2,1) was used to determine intra- and inter-examiner reliability, with a 95% confidence interval, minimum detectable change, and standard error of the measurement. Intra-rater reliability was considered low to high in the arm and forearm region. Inter-rater reliability in the arm region was considered low and in the forearm region low to moderate. Our results indicate that spiral FCB has low to moderate intra-examiner and inter-examiner reliability.
Breast Metastasis of a Completely Regressed Cutaneous Melanoma – Case Report and Review of Literature
Authors: Luana-Andreea Boșoteanu , Mariana Așchie , Tony Hangan , Oana-Andreea Ursică , Mădălina Boșoteanu
Published: September 2022

Spontaneous regression of cutaneous melanoma represents a more frequent circumstance in tumors with intense MelanA immunoprofile. Melanoma-derived breast metastases are uncommon and have been predominantly reported in premenopause, as an indicator for widespread disease. We report the case of a 60-year-old female patient, who presented to the surgical department after auto-palpation of a left mammary mass. Digital mammography indicated malignant characteristics, also objectified in the ipsilateral axillary lymph nodes. The microscopical examination and immunohistochemical profile revealed left nodal and upper-outer mammary quadrant metastases of a BRAF-positive achromic melanoma. The clinical and dermoscopic evaluation confirmed the complete regression of the malignant melanocytic lesion, localised at the level of the right inframammary fold. The upper-outer breast quadrant designates the main site of primary tumors (66%), as well as metastases of other malignancies (50%), due to its well-represented vascularisation and glandular tissue. Dermoscopic characteristics of regressed melanoma comprise scar-like depigmentation and polymorphous vessels (irregular linear and globular). The particularities of this case include the age > 40 years old, survival under therapy with Vemurafenib superior to that cited in the literature (24 months to this date), the involvement of the contralateral lymph nodes in relation to the skin lesion and the inverse diagnostic approach – from pathologist to dermatologist. Completely regressed achromic melanoma, identified through diagnostic techniques performed on clinically apparent loco-regional and distant metastases, represents a rare dermato-oncological entity, with controversial implications regarding the prognosis and survival, that requires future histopathological and dermoscopic homogenization.