bluuebunny/crossref_metadata_2025 huggingface dataset:
Robotic repair of a right paraduodenal hernia: a clinical presentation and management
Authors: Fysel Afzal Muhammed , P Reddy Abhinaya , Kumbhar Uday Shamrao
Published: December 2024

Paraduodenal hernias are rare internal hernias in which the small intestine becomes trapped behind the mesentery of the colon. These hernias can lead to bowel obstruction and ischaemia, making early diagnosis and intervention crucial. Patients often exhibit non-specific symptoms, highlighting the importance of using CT imaging for diagnosis. Prompt surgical correction is necessary to prevent severe complications such as bowel ischaemia or necrosis. While open and laparoscopic approaches are well-established, there is limited evidence on the robotic repair of paraduodenal hernias as a minimally invasive technique. This case report describes a man in his early 30s who presented with persistent abdominal pain and vomiting. Imaging revealed a right paraduodenal hernia with characteristic CT findings showing clustered jejunal loops and abnormal mesenteric rotation. The patient successfully underwent robotic hernia repair, which involved identifying and reducing the hernia sac and securing the defect with polypropylene sutures. The postoperative recovery was complication-free. This case underscores the effectiveness of robotic techniques in managing this rare presentation and emphasises the importance of timely diagnosis and intervention.
Structural and political determinants of health among Syrian refugee young adults in the Bekaa, Lebanon: a prospective cohort study of the impact of security raids on perceived discrimination and well-being
Authors: Ghandour Lilian , Brown Grant , Tleis Malak , Al Masri Hanan , Fares Marwa , Al Halabi Fadi , Najjar Yamen , Louis Bayan , Afifi Rima A , Nakkash Rima
Published: December 2024

Objectives

In this work, which forms part of a larger study of a longitudinal intervention focused on empowering Community Mental Health Workers in a humanitarian context, we examine changes in and correlates of well-being of refugees as a result of discriminatory practices by the State, with comparisons motivated by a mechanistic model of well-being.

Design

This cohort study examines well-being at a single follow-up time as predicted by baseline characteristics in response to a changing social conditions including security raids on our participants; the parent interventional randomised trial focuses on a population of youth in a refugee context, but the present work precedes the main intervention period.

Setting

Refugee populations are among the most vulnerable globally, and the total refugee population is growing dramatically. As of 2022, more than 12 million Syrians have been forcibly displaced with 6.5 million of them classified as refugees. In Lebanon specifically, tension between refugees and the host government has recently risen most evident through security raids, threatening the well-being of already displaced persons.

Participants

The study recruited Syrian refugee young adults (18–24 years) who have completed at least high school; additional inclusion criteria included: living in the catchment areas within the Bekaa at the time of screening, having been involved in non-governmental organisations (NGOs) or service to their community and having expressed motivation to serve their community. Applicants who fit the inclusion criteria were further screened by a psychiatrist to ensure that they were not experiencing acute distress at the time of recruitment (February 2023–March 2023). Recruitment occurred through posters on social media platforms of Multi-Aid Programmes. Ninety-two young adults were randomly assigned to one of the three randomised controlled trial arms.

Interventions

None at the time of the study.

Primary and secondary outcome measures

Primary outcomes were measures of well-being at baseline and follow-up.

Results

We find that the ability of NGOs to work with refugee populations may be threatened in important ways by government security raids, with possibly the most vulnerable subjects participating at baseline being less likely to respond during the raids. Moreover, we discuss the paradoxical short-term effects of the isolation induced by the raids, where daily experience of stigmatising events actually decreased during this period.

Conclusions

These results highlight the challenging environment in which refugees in Lebanon live in, and raise important questions about long-term solutions to the crisis.

Trial registration number

NCT05265611; LBCTR2023015206.
Building Narratives and Probing Concepts: Preparing Materials for Co-Design with Autistic Livestreamers
Authors: Mok Terrance , Hartley Tyson , Tang Anthony , McCrimmon Adam , Oehlberg Lora
Published: December 2024

Based on ten semi-structured interviews with autistic Twitch streamers, we introduce a series of scenario-based design narratives coupled with technology design concepts as a starting point for co-design discussion about autistic streaming. This work builds on prior thematic analysis of the unique intersection between autism and livestreaming. Our user-centered scenarios highlight the needs, goals, and challenges of autistic individuals in livestreaming contexts. By using evocative narratives, the scenarios serve to facilitate empathy and deeper engagement with the needs of autistic users, and help facilitate and support co-creative dialogues and discussions about new technology designs. We contribute this starting point for researchers and technology designers to co-create more inclusive and supportive online environments for autistic users.
FPGA-based Block Minifloat Training Accelerator for a Time Series Prediction Network
Authors: Zhou Wenjie , Qi Haoyan , Boland David , Leong Philip H.W.
Published: December 2024

Time series forecasting is the problem of predicting future data samples from historical information and recent deep neural networks (DNNs) based techniques have achieved excellent results compared with conventional statistical approaches. Many applications at the edge can utilise this technology and most implementations have focused on inference, an ability to train at the edge would enable the deep neural network (DNN) to adapt to changing conditions. Unfortunately, training requires approximately three times more memory and computation than inference. Moreover, edge applications are often constrained by energy efficiency. In this work, we implement a block minifloat (BM) training accelerator for a time series prediction network, N-BEATS. Our architecture involves a mixed precision GEMM accelerator that utilizes block minifloat (BM) arithmetic. We use a 4-bit DSP packing scheme to optimize the implementation further, achieving a throughput of 779 Gops. The resulting power efficiency is 42.4 Gops/W, 3.1x better than a graphics processing unit in a similar technology.
Characterization of upper esophageal sphincter pressures relative to vocal acoustics
Authors: Hoffmeister Jesse D. , Konczak Jürgen , Misono Stephanie N.
Published: December 2024

We identified relationships between upper esophageal sphincter (UES) pressures and vocal acoustics during phonation in vocally healthy individuals, potentially reflecting the influence of strength of vocal fold adduction and other phonatory factors on vocal acoustics. This methodology could lead to the development of a clinical and research tool that could provide insight into the strength of vocal fold adduction, a critical factor influencing voice quality that has historically been difficult to assess.
The Role of Mammographic Breast Area/Microcalcification Cluster Area (BA/MCA) Ratio in the Classification of BI‐RADS 4 Lesions: A Step for Development of Artificial Intelligence in Breast Cancer Patients
Authors: Bahçecioğlu Ibrahim Burak , Morkavuk Şevket Barış , Çimen Şebnem , Turan Müjdat , Çetinkaya Gökay , Gülçelik Mehmet Ali
Published: December 2024

Introduction: The working principle of artificial intelligence in medicine is primarily as follows: The data are collected and entered into the system, the computer uses an algorithm to gather information via these data, and finally, it analyzes this algorithm to utilize in the diagnosis and treatment of the disease. In this study, we investigated the achievement of mammographic breast area/microcalcification cluster area ratio (BA/MCA) in the grouping of BI‐RADS 4 (a, b, c) lesions. We planned to contribute to the development of artificial intelligence in medicine with a simple calculation program to be attached to the mammography computer.

Methods: 125 patients who underwent surgery with the diagnosis of mammographic BI‐RADS 4 lesion (could not be detected in lesion‐specific ultrasonography) between 2019 and 2022 in the Department of Surgical Oncology of Health Sciences University Gulhane Medical Faculty Training and Research Hospital were retrospectively examined. The mammographic MCA was divided by the breast area and their ratio was calculated. The relationship between the ratios we found and the BI‐RADS values defined by radiology was analyzed.

Results: We found the median BA/MCA value of BI‐RADS 4a patients to be 24943.5, BI‐RADS 4b patients to be 12609.2, and BI‐RADS 4c patients to be 11547.1 (p = 0.003). According to ROC curve analysis, we detected the BA/MCA ratio for BI‐RADS 4c to be 14183.34 (AUC = 0.686, p = 0.005, sensitivity 54.2%). This ratio is inversely related, and the probability of BI‐RADS 4c increases in patients with a BA/MCA ratio less than 14183.34. We revealed that the malignancy rate of radiological BI‐RADS 4c patients was 90%, and the cutoff value of BI‐RADS 4c patients was 72%. Using both classifications together, we detected the malignancy rate to be 98%.

Conclusion: The increase in the ratio of MCA to BA might have a place in the differentiation of BI‐RADS 4 lesions. We foresee that artificial intelligence could also have a place in the classification of BI‐RADS lesions with software to be installed on the mammography computer.
Food Security Resilience and Humanitarian Aid in Mali: A Case Study of Bandiagara Cercle
Authors: Mumararungu Innocent , Ya-Bititi Gisaro Ca-Madeberi , Rwirahira John , Burny Philippe
Published: December 2024

Mali’s food security strategies focus on improving agriculture, water management, and diversifying livelihoods. While initiatives like climate‐smart agriculture show promise, challenges like limited resources, market access, and political instability persist. Gender inequalities and reliance on external aid further hinder progress, making it difficult for Mali to build sustainable, self‐reliant food systems and ensure long‐term resilience. This research assessed the effectiveness of humanitarian aid interventions in enhancing food security resilience in the Bandiagara Region of Mali. It is aimed at evaluating the quality and sufficiency of the food provided to beneficiaries, as well as the alignment of aid efforts with local needs. The study employed a mixed‐methods approach, combining quantitative household surveys with 295 respondents across 14 villages and qualitative data through semistructured interviews with 37 local authorities selected on purposive sampling and focus group discussions with beneficiaries. The findings indicated that while the aid interventions were generally relevant and well executed, with beneficiaries expressing satisfaction with the quality of the millet provided, there were significant concerns regarding the quantity of food distributed. Many beneficiaries felt that the portions were insufficient to meet their needs, especially in the context of recurring food shortages. This highlighted the need for more tailored, context‐specific aid allocation strategies, ensuring that the quantity of food provided aligns better with local requirements and the scale of food insecurity, thereby enhancing the overall effectiveness of humanitarian support. It is recommended to expand and continue millet distribution programs, with enhanced monitoring mechanisms to ensure resource effectiveness. Emphasizing customized food allocation and increased community engagement will strengthen local ownership and resilience. By aligning aid with local needs and improving intervention targeting, these strategies are aimed at creating a more sustainable and equitable food security system in the Bandiagara Region, better equipping it to withstand future food insecurity challenges.
Design of Observation Class Remotely Operated Vehicles (OCROV) for an Exploration Operation in Restricted Underwater Channel
Authors: Srinakaew Sarawuth , Kesvarakul Ramil
Published: December 2024

Unmanned underwater vehicles (UUVs) are currently one of the practical instruments to complete some human unreachable tasks such as deep‐sea exploration, hazardous chemical‐contaminated underwater areas, and very tight or narrow underwater channels. A remotely operated vehicle (ROV), one of the UUV categories, plays an important role in several missions and has been an active field of engineering research since its introduction. In this work, the new observation class ROV (OCROV) hull designs are introduced to provide more understanding of drag prediction, improve power management, and prolong the endurance. To represent the restricted underwater channel, the fluid domain duplicated the size of the underground water trunk main in Northern Bangkok with a diameter of 1000 mm is focused. The OCROV hull designs are based on a streamlined torpedo‐like shape OCROV. Computational fluid dynamics (CFD) code with Reynolds‐averaged Navier–Stokes (RANS) equations is used to calculate total resistance (RT), frictional resistance (RF), and pressure resistance (RP). The results for restricted areas are also compared against free stream (unbounded) conditions to introduce the blockage and its effects.
Figure 5 from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

BM-derived CD8+ T cells from responders (CR) to AZA show an enhanced ISG molecular signature compared with nonresponders (FAIL) in scRNA-seq analysis. A, Comparison of separate UMAPs for CR (a total of 13,667 cells, including 7,571 from patients with MDS and 6,096 cells from patients with secondary AML, respectively) and FAIL patients (a total of 14,782 cells, including 8,026 cells from patients with MDS and 6,756 cells from patients with secondary AML, respectively). B, Stacked bar chart showing the average distribution of clusters between the two groups. The percentage of cluster 10 (proliferative) was increased in CR compared with FAIL patients (unpaired Student t test, P = 0.0418). C, Dot plot representing MSigDB (Hallmark 2020) enrichment analysis of positively enriched pathways in CR patients. Enriched pathways with a q-value <0.05 (Benjamini–Hochberg correction) are shown. D, Gradient expression of representative selected genes involved in IFN-related pathways, as they are projected onto UMAPs. E, ISG score of cluster 0 (GZMK) and violin plots showing the expression levels of the top differentially expressed IFN-stimulated genes of cluster 0 (GZMK) between CR and FAIL. F, ISG score of cluster 1 (EOMES) and violin plots showing the expression levels of the top differentially expressed IFN-stimulated genes of cluster 1 (EOMES) between CR and FAIL. G, ISG score of cluster 2 (CTL_1) and violin plots displaying the expression levels of the top differentially expressed IFN-stimulated genes of cluster 2 (CTL_1) between CR and FAIL. H, ISG score of cluster 4 (CTL_2) and violin plots displaying the expression levels of the top differentially expressed IFN-related genes of cluster 4 (CTL_2) between CR and FAIL.
Figure 4 from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

Profiling of BM-derived CD8+ T cells of patients with HR-MDS and secondary AML with scRNA-seq. A, UMAP of CD8+ T cells identified 11 clusters. A total of 28,449 CD8+ T cells were pooled from four patients with HR-MDS (15,597 cells) and five patients with secondary AML (12,852 cells). B, Bubble plot depicting the average expression of genes used to characterize the clusters. C, Expression of selected genes projected onto UMAPs. D, Heatmap showing selected top DEGs for each cell cluster. E, Ridgeline plots displaying the cytotoxic signature score for each cell cluster, as defined by the expression of key-related genes. F, Ridgeline plots displaying the cell-cycle signature score for each cell cluster.
Data sheet 3 from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

Data sheet 3
Table S1 from Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines
Authors: Dodson Anne E. , Shenker Sol , Sullivan Pamela , Nayak Sumeet U. , Middleton Chris , McGuire Michael , Chipumuro Edmond , Mishina Yuji , Tobin Erica R. , Cadzow Louise , Wylie Andrew A. , Sangurdekar Dipen
Published: December 2024

Mutation contexts for cell lines with WGS available.
Figure S5 from Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines
Authors: Dodson Anne E. , Shenker Sol , Sullivan Pamela , Nayak Sumeet U. , Middleton Chris , McGuire Michael , Chipumuro Edmond , Mishina Yuji , Tobin Erica R. , Cadzow Louise , Wylie Andrew A. , Sangurdekar Dipen
Published: December 2024

Alignment of HRD predictions to tumor types using Celligner
Data from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

Abstract
CD8+ T cells are crucial for antitumor immunity. However, their functionality is often altered in higher-risk myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML). To understand their role in disease progression, we conducted a comprehensive immunophenotypic analysis of 104 pretreatment bone marrow (BM) samples using mass and flow cytometry. Our findings revealed an increased frequency of CD57+CXCR3+ subset of CD8+ T cells in patients who did not respond to azacitidine (AZA) therapy. Furthermore, an increased baseline frequency (>29%) of the CD57+CXCR3+CD8+ T-cell subset was correlated with poor overall survival. We performed single-cell RNA sequencing to assess the transcriptional profile of BM CD8+ T cells from treatment-naïve patients. The response to AZA was linked to an enrichment of IFN-mediated pathways, whereas nonresponders exhibited a heightened TGF-β signaling signature. These findings suggest that combining AZA with TGF-β signaling inhibitors targeting CD8+ T cells could be a promising therapeutic strategy for patients with higher-risk MDS and AML.
Significance:
Immunophenotypic analysis identified a BM CD57+CXCR3+ subset of CD8+ T cells associated with response to AZA in patients with MDS and AML. Single-cell RNA sequencing analysis revealed that IFN signaling is linked to the response to treatment, whereas TGF-β signaling is associated with treatment failure, providing insights into new therapeutic approaches.
Impact of working conditions and other determinants on the risk of substance misuse among healthcare residents: results of a cross-sectional study
Authors: de Ternay Julia , Nohales Ludivine , Fort Emmanuel , Pelloux Sophie , Coste Clio , Leblanc Pierre , Wallon Martine , Fassier Jean-Baptiste , Rolland Benjamin ,   on behalf of the BASIL study group
Published: December 2024

Introduction: Substance misuse significantly impairs psychosocial functioning and correlates with many environmental factors, including working conditions. We investigated the influence of working conditions and other determinants on the risk of substance misuse among healthcare residents of city name withheld for review, France.
Methods: We conducted an online survey among medicine, dentistry and pharmacy residents of city name withheld for review from May 30, 2022, to July 15, 2022. Participants reported their age, sex, residency specialty, and living conditions and completed the French Job Content Questionnaire, the Alcohol Use Disorder Identification Test – Consumption, and questions exploring their current tobacco, alcohol, and illicit drug use. We constructed directed acyclic graphs to model the effect of working conditions on substance misuse and used them to perform multivariable logistic regressions.
Results: Among the 1,936 residents of the city name withheld for review subdivision, 904 (46.7%) completed the survey. Among these, 54.0% exhibited alcohol misuse, 23.7% reported tobacco misuse, and 34.5% reported illicit drug misuse. Working more than 48 hours per week was not associated with any substance misuse. Low social support at work predicted the use of illicit drugs (aOR: 1.49, 95% CI [1.04; 2.13]). Compared with general medicine residents, psychiatric residents had greater odds of reporting tobacco misuse (aOR: 2.28, 95% CI [1.14; 4.58]) and illicit drug misuse (aOR: 2.51, 95% CI [1.33; 4.74]). Pediatric and pharmacy residents had lower odds of reporting alcohol misuse (aOR: 0.42, 95% CI [0.21; 0.84] and OR: 0.53, 95% CI [0.28; 0.98], respectively).
Conclusions: Social support at work significantly impacts the risk of substance misuse among healthcare residents, as do other factors, such as residents’ health specialty. These findings contribute to the development of appropriate institutional policies and support programs to improve the well-being of healthcare residents.
Trends and the Role of Gene-Environment Interactions in Idiopathic Membranous Nephropathy in Northern China
Authors: Hou Wanyin , Shi Sufang , Yan Zhe , Liu Maodong , Guo Gengxin , Zhang Yujing , Dong Yun , Gao Junjie , Sun Fuyun , Hu Guicai , Zheng Zhaoxia , Duan Liping , Zhang Haisong , Liu Bing , Li Shaomei , Jiao Sumin , Wang Jinwei , Cui Zhao , Wang Suxia , Li Ying , Fu Shuxia , Zhao Minghui
Published: December 2024

Introduction: Idiopathic membranous nephropathy (iMN) has become one of the most prevalent primary glomerular diseases, with a marked increase in prevalence over the past two decades in northern China. Fine particulate matter (PM2.5) is considered to be associated with this rising prevalence. In this study, we aim to evaluate the trends of iMN in relation to improved air quality and conduct a cross-sectional study in Hebei province (northern China, near Beijing) to investigate the role of gene-environment interactions in its development.
Methods:
This study established two cohorts. Cohort 1 included 22,937 pathology reports from Peking University First Hospital (2002-2021) to assess iMN prevalence. Cohort 2 comprised 5,635 iMN patients from 11 cities in Hebei Province (2009-2013). DNA samples from 374 iMN patients and 1,259 controls were genotyped for SNPs rs4664608 (PLA2R1) and rs2187668 (HLA-DQA1). Patients were stratified by air pollution risk levels. The annual percentage change (APC) and average annual percentage change (AAPC) were estimated using a join-point regression model. Gene-environment interactions were analyzed using logistic regression and epinet-calculation.
Results:
In Cohort 1, 5,586 patients with iMN were identified, representing 24.3% of the 22,937 patients from 2002 to 2021. The general population showed a significant increase in iMN proportion with an APC of +12.7% per year from 2002 to 2014 (95% CI: 10.3 to 17.5, p < 0.001), followed by a decline with an APC of -5.6% per year from 2014 to 2021 (95% CI: -9.6 to -2.6, p < 0.001).In Hebei Province, the iMN frequency rose significantly with an APC of +17.6% per year from 2002 to 2016 (95% CI: 14.5 to 28.6, p < 0.001), peaking at 60%, and then declined with an APC of -5.5% per year from 2016 to 2021 (95% CI: -13.1 to -1.2, p = 0.02). Cohort 2 highlighted significant regional variation in iMN incidence across Hebei Province. Geographic exposure to pollution was identified as an independent risk factor for iMN (RR 1.49, 95% CI 1.38–1.56, p<0.001). Gene-environment interaction analysis revealed that patients with risk alleles in the PLA2R1 gene and exposure to risk environments had a markedly increased risk of developing iMN (OR=38.72, 95% CI 11.95-125.46, p<0.01).
Conclusion:
The annual growth rate of iMN in northern China appears to be slowing down. Gene-environment interactions may have contributed to the previously observed increase in iMN prevalence.
Macrophage Evolution during Progression of Hepatitis Virus B-Related Acute-on-Chronic Liver Failure
Authors: Rao Jiawei , Ye Dongmei , Ren Ao , He Wenjin , Zhang Xuzhi , Chen Pengrui , Jian Qian , Fu Zongli , Deng Ronghai , Hu Yixin , Gao Yifang , Ma Yi
Published: December 2024

Introduction: Hepatitis B virus (HBV)-related liver diseases, including hepatitis, cirrhosis, and liver failure, seriously threaten human lives and health worldwide. Innate and adaptive immune cells are all thought to participate in HBV-related diseases. However, there is a lack of information on the comprehensive landscape of the immune microenvironment. Methods: In this study, single-cell ribonucleic acid sequencing was performed on liver samples obtained from patients diagnosed with hepatitis, cirrhosis, and acute-on-chronic liver failure, which were caused by HBV. Trajectory analysis was performed to analyze the evolution of cell subsets, and branch expression analysis modeling was applied to visualize the changes in gene expression during evolution. Results: Finally, there was a significant increase in adaptive immune cells in the hepatitis and cirrhosis groups, whereas more innate immune cells were observed in the liver failure group. Furthermore, we found that monocytes underwent remarkable transcriptomic changes into FABP5+ macrophages, promoting the degranulation and chemotaxis of neutrophils through RESISTIN signaling, and LGMN+ macrophages, with the sequential activation of antigen presentation and defense to pathogens through SPP1 signaling. Conclusion: Macrophages were revealed as central to the progression of acute-on-chronic liver failure as they regulated the activation or inhibition of other immune cells, which could help in developing an effective novel therapy.
Optimizing Digital Transition: Addressing Challenges in Modernizing Inventory Systems in Primary Healthcare Facilities
Authors: Bolaños Jam Claudinee S. , Diaz Yves Evita S. , Lalaguna Jeseneth Danica A. , Malang Bernandino P. , Philippines Jocelyn DS.
Published: December 2024

This study investigates the challenges and potential solutions associated with modernizing inventory systems in primary healthcare facilities in the National Capital Region (NCR) of the Philippines, emphasizing operational efficiency, resource management and staff training. A descriptive research design was applied, using both quantitative and qualitative approaches. Data was collected from 67 trained staff members through purposive sam-pling, ensuring diverse perspectives across various organizational roles. The questionnaire was evaluated in relation to users' perceptions of satis-faction, operational efficiency, and the perceived difficulties with digital inventory systems. Reliability is established with the help of Chronbach's Alpha, and ANOVA, used in establishing the relationship between user sat-isfaction and operational effectiveness. From the thematic analysis of the questionnaire, lack of infrastructure, lack of training, and fractured supply chains were pointed out as being the obvious challenges that reduce the smooth digital transition. The study found that while digital transfor-mation has the potential to enhance inventory management and healthcare delivery, significant barriers must be addressed to achieve full adoption. Overall, findings help highlight the need for focussed training with strong digital solutions in optimizing resource management and service delivery in public health settings, providing valuable insights for policymakers and healthcare administrators.
Excellence In E-Governance: Replicable Innovations from Quezon City
Authors: . Pacaño, Jr. Edgar A , Tayaoan Harold May B. , Molina Kenneth Anthony , Da Costa Estefânia L. S. , Neverio Norman A. , Malang Bernandino P. , Malang Jocelyn DS.
Published: December 2024

This study explores how Quezon City’s e-governance programs—QC e-services, QCitizen ID, and QC Biz Easy—have improved public ser-vice delivery by making services more efficient, transparent, and accessible. These initiatives offer practical benefits, including easy-to-use interfaces and broad device accessibility, making them adaptable for other Local Government Units (LGUs) interested in digital transformation. The research also addresses challenges, such as limited technology access, funding constraints, and the need for strategies to manage resistance to change. Findings show that Que-zon City’s approach not only enhances local services but also sets a benchmark for other municipalities seeking to innovate and im-prove public service delivery through e-governance.
From Classroom to Career: A Tracer Study on The Acchievements and Employment Patterns of BS in Accountancy, BS in Accounting Information System and BS in Entrepreneurship Graduates
Authors: Bongalonta Michael B. , Bongalonta Michelle M. , Gigantoca Santos , Naz Graham M. , Melitante Allyboy , Inocentes Marilyn N. , Sales Diana V. , Despuig Led L. , Fulgar Abegail A. , Delmonte Gloriane , Ambrose Benjamin , Barcarse Eula Ceeline , Balaguer Renebec A. , Especial Mary ann D.
Published: December 2024

This study evaluates the achievements and employment patterns of BS Accountancy, BS in Accounting Information Systems, and BS in Entre-preneurship graduates from Sorsogon State University Bulan Campus (2019-2023). It assesses the extent of Program Educational Objec-tives (PEOs) achievement, analyzes employment rates, and gathers employer feedback on graduates' competencies. Using a descriptive-survey design, data were collected from recent graduates, employers, and notable alumni. Findings indicate high success in achieving PE-Os, strong employment rates, and positive employer evaluations. Recommendations include curriculum updates, enhanced industry partnerships, and expanded career services to further support grad-uate success.
Enhancing Public Service Delivery and Citizen Participation: The Synergistic Effects of E- Governance and Social Media
Authors: Asadon Ma. Francicsa A. , Brucal Alyssa P. , Claveria Pia Sarah L. , Lacson Jan Tracey N. , Malang Bernandino P. , Malang Jocelyn DS.
Published: December 2024

This study investigates the effects of social media and e-governance on public service delivery and citizen engagement in the Philippines. It is based on the idea that digital technology can enhance the efficiency, transparency, and trustworthiness of government, thus using the Unified Theory of Acceptance and Use of Technology (UTAUT2) to identify key factors driving adoption among citizens and government bodies. E-governance decreases the costs, errors, and delay in service delivery among Laguna residents, according to data from a survey. Public participation is enhanced by social media with more satisfaction and trust than other traditional media. Together, these tools improve the responsiveness of public policy and effectiveness to the public. Challenges such as infrastructural limitation, digital resistance, and privacy concerns have however been facing full adoption. Policymakers should remove the above barriers to ensure a totally realized benefit of digital governance for a more transparent, efficient, and participatory government.
Desvio do complemento na lepra
Authors: Gomes J. M.
Published: December 2024

As reacçôes de desvio do complemento na lepra têm sido feitas com varios intuitos. Certos autores procuraram simplesmente conhecer sua sensibilidade ao antigeno de Wassermann. Outros. um meio de deslinde entre a syphilis e a lepra.
Going Round in Circles: A Cognitive Bias in Geometric Reasoning
Authors: Hamami Yacin , Amalric Marie
Published: December 2024

Deductive reasoning is essential to most of our scientific and technological achievements and is a crucial component to scientific education. In Western culture, deductive reasoning first emerged as a dedicated mode of thinking in the field of geometry, but the cognitive mechanisms behind this major intellectual achievement remain largely understudied. Here, we report an unexpected cognitive bias in geometric reasoning that challenges existing theories of human deductive reasoning. Over two experiments involving almost 250 participants, we show that educated adults systematically mistook as valid a set of elementary invalid inferences with points and circles in the Euclidean plane. Our results suggest that people got “locked” on unwarranted conclusions because they tended to represent geometric premisses in specific ways and they mainly relied on translating, but not scaling, the circles when searching for possible conclusions. We conducted two further experiments to test these hypotheses and found confirmation for them. Although mathematical reasoning is considered as the hallmark of rational thinking, our findings indicate that it is not exempt from cognitive biases and is subject to fundamental counter-intuitions. Our empirical investigations into the source of this bias provide some insights into the cognitive mechanisms underlying geometric deduction, and thus shed light on the cognitive roots of intuitive mathematical reasoning.
Object Feature Memory Is Distorted by Category Structure
Authors: Tandoc Marlie C. , Dong Cody V. , Schapiro Anna C.
Published: December 2024

Memory systems constantly confront the challenge of capturing both the shared features that connect experiences together and the unique features that distinguish them. Across two experiments, we leveraged a color memory distortion paradigm to investigate how we handle this representational tension when learning new information. Over a thirty-minute period, participants learned shared and unique features of categories of novel objects, where each feature was assigned a particular color. While participants did not differ in how accurately they remembered these features overall, when inaccurate, participants misremembered the color of shared (relative to unique) features as more similar to the category’s average color, suggesting more integration of shared features in memory. This same rapid representational warping manifested in a neural network model trained on the same categories. The work reveals how memories for different features are rapidly and differentially warped as a function of their roles in a category.
The Spectral Imagination; or, Using the Past to Re-imagine the Future
Authors: Millar Charlotte-Rose
Published: December 2024

This piece explores the phenomenon of ghosts in early modern England to highlight the strength of the premodern imagination as a tool for conceptualising the future. Ghosts can be viewed as an imaginative resource to fulfil social obligations or to express hopes and fears. There is a strong emotional element here. For people living in both the premodern and modern world, ghosts could (and can) be a way in which emotions became externally embodied, either in a sense of a presence, or in a more tangible form. As such, this piece explores the links between supernatural belief, strong emotions and the imagination of multiple futures.
Guénonian Traditionalism at the Grand Mosque of Paris: a Profile of a Sufi Teacher
Authors: Stegmann Ricarda
Published: December 2024

This article discusses the Sufi teachings of a religious authority who has taught at the Al-Ghazali Institute of the Grand Mosque of Paris. It first shows that this teacher’s vision of Sufism and of the Orient and Occident is based on the views of the French thinker René Guénon, but with a stronger Islamic accent, similar to Michel Valsan’s reception of Guénon. It then discusses which new implications this Guénonian-tinged Sufism contains, firstly, when it is performed for a migrant audience, and secondly, when it is taught at the highly symbolic site of the Grand Mosque of Paris. In this context, we also discuss parallels and differences between Guénon’s valorisation of the Orient on the one hand and colonial Orientalism as manifested at the Mosque of Paris since the 1920s on the other hand. Finally, we will present the teacher’s positions and way of thinking as representing a place where diverse currents of thought and political claims intersect and show that this challenges their potential classification as “integrated” or “non-integrated” within current political debates.
Rethinking Insularity in the Canadian Constitutional System
Authors: Fusco Sara
Published: December 2024

The article offers an analysis of the potential of the insularity concept into the Canadian constitutional framework considering environmental degradation and Indigenous rights. The analysis highlights how ecological conservation supports the right to self-determination of the most vulnerable social groups, island communities and Indigenous Peoples, as the Inuit in the Arctic Archipelago. The discussion introduces the most recent interpretation of article 7, 15 and 35 of the Canadian Constitutional law and the distinctions-based approach of the modern treaties. For these reasons, the article is a valid exercise in legal transplants among different constitutional cases of insularity.
An Examination of the Ming Empire’s Inner Asianness: Focusing on Qing Dynasty Analogies
Authors: Zhong Han , Phurbu Dorje Metters Kevin
Published: December 2024

Among overseas “New Qing History” scholars, the Ming Empire is typically interpreted as an ethnically Han-Chinese regime that lacked the characteristics of Inner Asian polities. This author, however, asserts that this view is incorrect. Like the Qing, the emperors of the Ming ruled as qaghans over their northern steppe subjects and as the incarnation of the bodhisattva Manjusri in the eyes of Tibetan-Mongolian Buddhists. Also like their Qing dynasty counterparts, the Ming Empire produced multilingual documents, combining Chinese and ethnic minority scripts, a potent symbol of their “universal” rule. Lastly, the Ming emperors also actively pursued a policy of promoting governance through religion, creating a cultural and political legacy that would come to directly shape later relations between the Qing empire and the frontier regions of their empire.
Beyond the Lens: the Telescope’s Influence on Art and Vision in Ming-Qing China
Authors: Huang Bing
Published: December 2024

The telescope was invented during the early seventeenth century in Europe and introduced to China during the Ming dynasty. This article discusses how the telescope shattered the epistemological understanding of vision in China in the late Ming to the mid-Qing dynasty. The telescope revolutionized not only scientific ways of seeing but also changed many aspects of culture and the philosophical understanding of vision itself. I endeavour to explain the visual perception afforded by telescope, and discuss the social aspects of that vision and the multiplicity of applications of the telescope in China through scientific books, records of imperial workshops, poetry, novels, and paintings. I argue that telescope not only helped the Chinese to imagine how to visually conquer space but also how to overcome the limits of time.
The Engineering Paradigm and Its Historical Evolution and Construction
Authors: Zhang Xiuhua
Published: December 2024

Engineering is directly related to civilization, and in the face of the “emergency” posed by modernity, there is an imperative need to change the practical approaches of modern engineering that underlines modernity. Engineering thinking and paradigms in different eras often manifest in distinct modes of engineering, contributing to various types of civilizations. To date, in a morphological sense, humanity has experienced the “engineering in-itself paradigm” of the premodern agricultural civilization, which adapts to nature, and the “engineering for-itself paradigm” of the modern industrial civilization, which dominates nature. It is now moving toward the Engineering Ecology Paradigm, the “engineering in- and for-itself paradigm” of a postindustrial civilization, which seeks harmony between humans and nature. To this end, it is not only necessary to establish the thinking of engineering ecology but also to consciously promote the transition of engineering paradigms, embracing holistic, synergistic, and ethical perspectives for sustainable and harmonious development.
Ethics and Politics: Two Parts of a Single Inquiry in Aristotle
Authors: Marwa Monchena Thomas
Published: December 2024

This article delves into examining how according to Aristotle’s understanding Ethics and Politics, though, considered independent fields of study today, they are closely related as two parts or dimensions of a single inquiry. Our interest in this question of how Aristotle conceived these two fields of inquiry in their relatedness is drawn by our discovery that in his work Nicomachean Ethics, Aristotle has given space to the discussion on the subject matter of politics. In Book 1 of Nicomechean Ethics some chapters are dedicated to examining the subject matter of politics, the aims of political science and the role of the political society is conceived to be the cultivation of virtuous life of the citizens. The foundation of this relationship lies on the fact that these two sciences are both practical sciences whose aim is the pursued and attainment of eudemonia, both individually and communally. Ethics and politics have a common method according to Aristotle. The practical truth that is proper to these practical sciences is achieved through the method called dialectic; which Aristotle conceives as an analytical instrument that facilitate by bringing clarity. Even the one who is an “amateur” to Aristotelian philosophy would realize that Aristotle has a conception according to which politics and ethics are related. This is a brief attempt to show the nature of that relationship. While the study of ethics shows the intrinsic requirements (virtues both moral and intellectual) for happiness, the study of politics seeks to show the best constitution (the best political climate) necessary for the cultivation of the life of virtues and consequently, the attainment of happiness.
Energetics of Atmospheric Meridional Teleconnection Patterns over the North Pacific in Winter
Authors: Satoh Ryo , Kosaka Yu , Nakamura Hisashi , Miyamoto Ayumu , Okajima Satoru
Published: December 2024

The western Pacific (WP) pattern, the North Pacific Oscillation (NPO), and the Pacific–North American (PNA) pattern are known as dominant meridional teleconnection patterns over the wintertime North Pacific. To investigate why these specific patterns are dominant, the energetics of atmospheric meridional teleconnection patterns over the wintertime North Pacific are comprehensively examined. A total of 286 meridionally dipolar circulation anomaly patterns are systematically extracted as regression anomalies onto 500-hPa zonal wind anomalies at various locations over the basin. Taking energy conversion/generation efficiency as a key metric, this study evaluates energy conversion with the climatological-mean state, feedback forcing from modulated high-frequency eddies, diabatic energy generation, and energy flux from the tropical atmosphere for each of the patterns. For all the patterns obtained from intraseasonal variability, baroclinic available potential energy conversion from the climatological-mean state contributes most efficiently to their maintenance. Meanwhile, barotropic kinetic energy conversion from the climatological-mean flow tends to play a secondary role, but it becomes more important if situated in the jet exit. As a net, energy conversion from the climatological-mean state and energy transfers from modulated high-frequency eddies act to energize all the patterns. Significant differences are found in net energy conversion efficiency among the patterns, arising mostly from differences in the efficiency of conversion from the climatological-mean state. Furthermore, the three dominant teleconnection patterns bear higher net conversion efficiency. In fact, net conversion efficiency is strongly correlated with the total energy possessed by each pattern, indicating a crucial role of the net energy conversion efficiency in the dominance of teleconnection patterns.
Musical Counterstories: Racialized Experiences of Asian/Asian American Music Teachers
Authors: Palkki Joshua , Hsieh Betina , Fitch Carlos A.
Published: December 2024

Despite being the fastest growing population in the United States and a part of many music education programs, Asian and Asian American (AAM) music teachers’ voices often are unheard in music education discourses. The purpose of this study was to begin bringing visibility to the experiences of AAM music educators. The research questions explored in this article are: How do AAM music teachers describe their experience in relationship to their racial identities? and How might AAM educators’ experience be similar or differ in relation to immigrant generational statuses and transnational contexts? We utilized Asian critical race theory as a framework to examine the experiences of 10 AAM music educators. Although collective themes emerged around patterns of racialization, each participant had unique experiences shaped by transnational contexts and immigrant generation. We hope that these data become part of a more robust discourse around AAM experiences in music learning and teaching.