bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Sodium Tripolyphosphate and Guar Gum on Physical Characteristics of Analog Rice from Gaplek Flour
Authors: Puspitasari Dyah Ayu , Pudjianto Karjawan , Darussalam Abdullah , Wicaksana Galuh Hendhitya , Hastuti Heru Pitria
Published: June 2024

Gaplek flour is a processed product of cassava preservation abundant during the harvest season in Lampung Province. The high carbohydrate content in cassava facilitates the processing of gaplek flour into carbohydraterich food source, such as analog rice. Therefore, this study aimed to investigate the effect of adding STPP and guar gum on the formulation of analog rice made from 70% gaplek flour and 30% corn flour. Analog rice was produced using the extrusion method with a twin-screw extruder. The results showed that the addition of STPP did not affect water absorption characteristics. The solubility of rice in deep water also decreased with increasing amounts of STPP and guar gum. Meanwhile, guar gum significantly increased water absorption and reduced the solubility of rice in water. The degree of gelatinization decreased with the addition of both materials. The addition of 0.3-0.5% STPP and 0.5-2% guar gum had no significant effect on hardness, stickiness, elasticity, and cohesiveness of analog rice prepared using a cooker.
Application of Foam Mat Drying for the Production of Tempoyak Powder
Authors: Utama Rozi Satria , Fajri Prima Yaumil , Azel Farid
Published: June 2024

The production of tempoyak powder is a significant attempt to preserve tempoyak. Therefore, this study aimed to determine the proper amount of albumin and maltodextrin to produce tempoyak powder using foam mat drying. This study was divided into two stages, namely producing tempoyak powder by foam mat drying method and determining the characteristics. In the production, egg albumin was used as foaming agent in three concentrations, namely 10%, 15%, and 20%, as well as maltodextrin as a filler in 0% and 5%. Chemical and physical characteristics, such as proximate test, pH, total titrated acid, bulk and tap density, Carr Index (CI), and Hausner Ratio (HR) were investigated. The result showed that moisture content of tempoyak powder ranged from 10.22 to 13.34%. Tempoyak powder with 20% albumin but no maltodextrin had the lowest moisture content. Furthermore, the addition of albumin without maltodextrin increased foam overrun, accelerating drying process and powdered tempoyak with lower moisture concentration. The addition of maltodextrin decreased foam tempoyak overrun, causing drying process to be slower. Tempoyak powder had protein content ranging from 8.71 to 13.12%, and with 20% albumin and no maltodextrin, the highest protein level of 13.12% was obtained. Fat content ranged from 6.99 to 8.15%, with the highest observed in tempoyak powder with 20% albumin and no maltodextrin. The addition of albumin as foaming agent increased protein and fat content. Furthermore, the total titrated acid in powdered tempoyak products was not significantly different from fresh tempoyak. The result suggested that the acid content does not considerably reduce while drying. Tempoyak powders had CI and HR values that ranged from good to excellent, showing good flowability and cohesiveness.
Effect of Adding Stevia Sweetener (Stevia rebaudianna) and Arabic Gum Filler on the Physicochemical Properties of Chayote Squash (Sechium edule) Powder Drink
Authors: Nuraziz Chofifah Endar , Khairi Amalya Nurul
Published: June 2024

Chayote squash (Sechium edule) is renowned for high potassium (125 mg), fiber (1.7 g), and antioxidant compounds including flavonoid, polyphenol, tannin, and saponin. The plant has the potential to be processed into powder drink with the addition of stevia powder and arabic gum . Stevia provides 200 – 300 times the sweetness of sucrose and non-calorie, while arabic gum is used as a bulking agent to improve the physical character of powder drink. Therefore, this study aimed to determine the physicochemical properties of chayote squash powder drink with variations of stevia powder and arabic gum. The method used was a two factorial complete randomized design with variations in stevia powder of 2% and 4% as well as arabic gum of 10% and 15%. Each treatment was repeated three times and powder drink was processed using foam mat drying method at 70 °C for 6 hours. The parameters observed include yield, water holding capacity (WHC), solubility, hardness, springiness, water content, ash content, pH, total dissolved solids (TDS), and antioxidant activity, while the data were analyzed using Two-way ANOVA without interaction. The results showed that the addition of stevia powder and arabic gum significantly affected yield, WHC, water content, pH, TDS, and antioxidant activity. However, no significant effect was observed on solubility, hardness, springiness, and ash content. The best formulation was found to be S2A2 containing 4% stevia powder + 15% arabic gum, with 9.69% yield, 37.65% solubility, WHC 37.44%, hardness 257.61 N, springiness 0.683, moisture content 5.02%, ash content 5.43%, pH 5.73, TDS 5.7 °Brix, and antioxidant activity of 143.00 ppm.
Molecular Docking, Synthesis and In Vitro Antiplasmodium Assay of Monoketone Curcumin Analogous from 2-Chlorobenzaldehyde
Authors: Mustika Chessy Rima , Astuti Endang , Marjan Muhammad Idham Darussalam
Published: June 2024

This research aimed to develop new curcumin analogous as antiplasmodium candidates. Six curcumin analogous (1-6) were proposed and docked against three Plasmodium falciparum receptors, namely PfENR, PfLDH, and PfATP6. The docking studies were carried out to predict the interaction among the compounds and receptors as well as their binding affinity. Three curcumin analogous (3, 4, and 6), which displayed specific interactions with the target receptors and possessed the lowest binding affinity were further proceeded to synthesis and in vitro antiplasmodium assay. Synthesis of the analogous 3, 4, and 6 was carried out from 2-chlorobenzadehyde via aldol condensation reaction and the products were obtained in good yields. Their in vitro antiplasmodium activities were then evaluated against P. falciparum FCR3 and 3D7 strains. The results showed that analogous 3, 4, and 6 were active against both strains with low levels of resistance. The in silico evaluation of the physicochemical and pharmacokinetic parameters showed that curcumin analogous displayed a better ADMET profile than curcumin, demonstrating the great potential of the developed curcumin analogous as antiplasmodium candidates.
Potensi Tanaman Lokal sebagai Tanaman Biofarmaka untuk Kesehatan di Desa Lemahbang dan Desa Pucung, Kecamatan Kismantoro, Kabupaten Wonogiri
Authors: Purwanta  , Jauharah Rafagusta Suhendar  , Aida Firzana Afifah Nur
Published: June 2024

Penggunaan obat tradisional menggunakan tanaman herbal telah menjadi bagian yang akrab dalam budaya masyarakat Indonesia. Tanaman herbal merupakan tanaman yang dapat berkhasiat dalam penyembuhan atau pencegahan segala macam penyakit. Tanaman herbal yang dikenal saat ini memiliki potensi untuk menjadi tanaman biofarmaka. Dari berbagai macam tanaman herbal, sebagian besar dapat ditemukan di Desa Lemahbang dan Desa Pucung, Kecamatan Kismantoro. Namun, untuk pemanfaatan tanaman herbal di Desa Lemahbang dan Desa Pucung masih sedikit dan hanya dimanfaatkan sebagai bumbu dapur atau jamu tradisional. Oleh karena itu untuk meningkatkan potensi tanaman herbal menjadi tanaman biofarmaka diperlukan adanya pengembangan lebih lanjut dalam hal pemanfaatannya. Pelaksanaan kegiatan Pengabdian kepada Masyarakat ini terbagi dalam tiga tahap, yaitu: 1) tahap persiapan; 2) tahap pelaksanaan; 3) tahap evaluasi. Ketiga tahapan tersebut dilakukan pada bulan Desember 2023 hingga Januari 2024. Dari kegiatan ini dikenalkan cara pembuatan jamu kunyit asem bubuk dan soothing gel lidah buaya. Hasil dari kegiatan ini adalah produk, data tanaman herbal di Desa Lemahbang, digitalisasi data, dan booklet mengenai daftar tanaman herbal yang ada di Desa Lemahbang. Dari kegiatan ini diperoleh kesimpulan bahwa kegiatan ini dapat meningkatan pengetahuan dan kesadaran masyarakat terhadap potensi tanaman herbal lokal dan akan dapat meningkatkan manfaat kesehatan dan ekonomi masyarakat. Proses digitalisasi melalui website desa memberikan akses yang lebih mudah bagi masyarakat untuk mengakses informasi seputar tanaman herbal. Pelatihan praktis juga memberikan manfaat langsung kepada para ibu PKK dalam pengolahan produk herbal sederhana.
Pendeteksian Sumber Air dalam Tanah untuk Memenuhi Kebutuhan Air Domestik di Desa Hargomulyo, Kecamatan Gedangsari, Kabupaten Gunungkidul
Authors: Akhmadi  , Arya Pangestu Hidayat  , Nina Alif Flour Rinda
Published: June 2024

Kabupaten Gunungkidul, khususnya Desa Hargomulyo, merupakan salah satu desa yang terdampak kemarau panjang tahun ini. Di desa ini terjadi permasalahan berupa kesulitan mendapatkan sumber air bersih. Oleh karena itu, penelitian ini memiliki tujuan dalam perkiraan potensi sumber daya air tanah di Desa Hargomulyo, yang selanjutnya dapat digunakan sebagai pedoman untuk melakukan pengeboran sehingga dapat memenuhi kebutuhan air domestik di desa tersebut. Metode yang digunakan dalam penelitian ini adalah metode Vertical Electrical Sounding (VES) dan metode elektromagnetik (EM) untuk mengetahui potensi air tanah, serta mengacu pada SNI 6728:1:2015 tentang penyusunan neraca spasial sumber daya alam untuk mengetahui kebutuhan air domestik. Metode VES dilakukan di Dusun Jatibungkus dan Mangli, sedangkan metode EM dilakukan di Dusun Suruh. Metode VES yang telah dilakukan tidak mendapatkan sumber air tanah, sedangkan melalui metode EM didapatkan sumber air tanah dengan debit 4.920 liter/jam. Kebutuhan air domestik di Desa Hargomulyo sebesar 441.900 liter/hari. Desa Hargomulyo memiliki topografi yang didominasi wilayah perbukitan sehingga metode geolistrik kurang efektif dilakukan di wilayah tersebut. Metode geolistrik hanya mendeteksi material batuan yang terdapat di bawah tanah, sedangkan di Desa Hargomulyo air tanah tersimpan di rekahan batuan sehingga metode geolistrik sulit untuk mendeteksi air tanah tersebut. Dalam mengatasi hal tersebut, dapat digunakan metode elektromagnetik. Metode ini cukup efektif jika dilakukan di medan yang didominasi wilayah perbukitan. Hasil perkiraan air tanah menggunakan metode EM dapat memenuhi sebagian kebutuhan air domestik di Desa Hargomulyo. Apabila nantinya dilakukan pendeteksian air lagi menggunakan metode ini, kebutuhan air domestik dapat terpenuhi dan permasalahan kekurangan air yang terjadi di Desa Hargomulyo dapat teratasi.
Pelatihan Pembuatan Tote Bag Ramah Lingkungan dengan Penerapan Teknologi Ecoprint Teknik Pounding pada Ibu-ibu PKK RT 03 Dukuh Sanggrahan, Tirtoadi, Mlati, Sleman
Authors: Yuliana Rizka Handayani  , Daereo Dzakwan Putra Widana  , Rachael Arnesta Torey  , Anya Yuniza D  , Annisa Hafshah A  , Unan Yusmaniar Oktiawati
Published: June 2024

Ecoprint merupakan sebuah teknik untuk memberikan pola pada kain ataupun bahan dengan menggunakan bahan alami sebagai pewarnanya. Ecoprint ini dapat dilakukan menggunakan bahan alam berupa daun, dan bunga. Sekarang ini ecoprint dapat diterapkan dalam setiap bahan seperti tote bag. Pembuatan tote bagecoprint menjadi langkah baru sebagai penerapan barang-barang ramah lingkungan. Melalui Kuliah Kerja Nyata (KKN) Periode ke-2 tahun 2023 Universitas Gadjah Mada pada Unit YO057 yang dilaksanakan di Kapanewon Mlati tepatnya di Kalurahan Tirtoadi mengangkat tema “Penanggulangan Kemiskinan”. Dicanangkan salah satu program kerja yakni “Pengembangan Budaya Usaha Melalui Sosialisasi Pembuatan Ecoprint Kepada Ibu-ibu PKK di Padukuhan Sanggrahan, Desa Tirtoadi dalam Upaya Pengembangan UMKM”. Kegiatan pengabdian masyarakat sesuai tema tersebut dilakukan melalui sosialisasi pembuatan ecoprint yang hasil akhirnya berupa tote bag ramah lingkungan. Pembuatan tote bag ecoprint yang dilakukan bersama dengan ibu-ibu PKK RT 03 Dukuh Sanggrahan memiliki tujuan untuk mengembangkan bakat dari ibu-ibu PKK sendiri dan dapat dijadikan sebagai usaha mikro rumahan. Teknik pukul merupakan teknik pembuatan ecoprint yang mudah untuk dilakukan dan dapat diterapkan pada kegiatan bersama ibu-ibu PKK. Kegiatan pembuatan ecoprint menghasilkan barang jadi berupa tote bag bermotif ecoprint dari bahan alami yakni daun-daun yang ada di sekitar RT 03 Dukun Sanggrahan. Ibu-ibu PKK RT 03 Dukuh Sanggrahan mampu melakukan pembuatan tote bag ramah lingkungan dengan menggunakan ecoprint teknik pukul. Dengan adanya kegiatan ini, diharapkan peran wanita di Dukuh Sanggrahan menjadi lebih besar dan memberikan peluang dalam bidang usaha rumahan serta dapat memberikan efek keberlanjutan yang baik kedepannya.
Epistemologi Lokal Masyarakat Desa Nemberala, Rote Barat dalam Kegiatan “Makameting”
Authors: Gloria Bayu Nusa Prayuda  , Agung Harijoko
Published: June 2024

Penelitian ini bertujuan untuk mengkaji unsur-unsur epistemologi dalam tradisi Makameting masyarakat Desa Nemberala, Rote Barat. Makameting merupakan kegiatan masyarakat pesisir Rote dalam pemenuhan kebutuhan hidupnya, yaitu dengan mengumpulkan makanan di pantai ketika air laut surut. Tradisi Makameting sudah dilakukan selama bertahun-tahun, menjadi suatu kebiasaan dalam keseharian masyarakat Rote, Penelitian ini menggunakan metode deskriptif-interpretatif, dengan sumber pustaka dan wawancara bersama masyarakat lokal sebagai acuan penulisan Hasil penelitian menunjukan bahwa terdapat unsur-unsur epistemik yang memberi prakondisi situasional kegiatan makameting yaitu unsur biologis, geografis dan kultural. Unsur biologi dalam makameting adalah cara masyarakat sebagai makhluk yang memiliki agensi memenuhi kebutuhan hidupnya, unsur geografi yang ditemukan adalah bagaimana lanskap pantai mendeterminasi dinamika sosial masyarakatnya, sedangkan usur kultural adalah bagaimana laut dipandang secara antropomorfik dan keseharian makameting itu sendiri.
Pengembangan Infrastruktur Pendukung dan Pemberdayaan Sumber Daya Manusia Pengelola Desa Wisata Pucung Ngangeni
Authors: Purwanta  , Arin Yusianti  , Muhammad Faqih  , Christy Paramitha Sabharaputri Kuncoro  , Renaldi Saputra
Published: June 2024

Desa Pucung merupakan salah satu desa yang ada di Kecamatan Kismantoro, Kabupaten Wonogiri, Provinsi Jawa Tengah. Faktor posisi Desa Pucung yang berada di dataran tinggi dan pegunungan membuat wilayah ini memiliki banyak potensi pariwisata seperti adanya wisata Skyview Watu Adeg. Puncak Watu Adeg di Desa Pucung kini menjadi objek wisata baru di wilayah timur Kabupaten Wonogiri yang menyuguhkan keindahan panorama alam daerah perbatasan antara Jawa Tengah dan Jawa Timur. Dari Puncak Watu Adeg, pengunjung bisa melihat panorama alam berlatar belakang Gunung Lawu dan wilayah timur Wonogiri. Pengembangan desa wisata telah menjadi fokus penting dalam upaya memajukan sektor pariwisata lokal. Dalam era digital saat ini, teknologi informasi dan komunikasi memainkan peran sentral dalam memperluas jangkauan promosi dan meningkatkan interaksi dengan komunitas lokal. Artikel ini bertujuan untuk menyajikan studi kasus mengenai pengembangan situs web desa wisata sebagai sarana untuk menggabungkan teknologi dengan upaya pengembangan pariwisata dan pemberdayaan komunitas di Desa Pucung. Melalui analisis mendalam terhadap implementasi situs web desa wisata, disoroti langkah-langkah strategis dalam merancang, mengembangkan, dan meluncurkan platform online ini. Hasil dari penelitian ini menggambarkan dampak positif yang dihasilkan dan interaksi yang lebih baik dengan komunitas lokal juga teramati, sehingga membantu dalam memperkuat identitas dan partisipasi masyarakat dalam pengembangan desa wisata secara holistik. Kesimpulannya, pengembangan situs web desa wisata memberikan wawasan yang berharga tentang bagaimana penerapan teknologi dapat memperkuat sektor pariwisata lokal sambil mendukung keterlibatan masyarakat dan pelestarian budaya.
Pengembangan Daya Saing UMKM melalui Pendampingan Pemasaran Digital di Kecamatan Kismantoro, Kabupaten Wonogiri
Authors: Purwanta  , Anirotun Nisa  , Ari Susanti  , Defa Rizky Pratama  , Lestari  , Raisma Nadhifa
Published: June 2024

Kecamatan Kismantoro, Kabupaten Wonogiri, Jawa Tengah merupakan salah satu daerah yang memiliki kekayaan alam melimpah. Potensi tersebut telah dimanfaatkan oleh warga setempat sebagai mata pencaharian, salah satunya melalui Usaha Mikro Kecil dan Menengah (UMKM) berupa home industry. Adapun jenis UMKM yang terdapat di wilayah ini adalah produksi jamu, industri genteng, anyaman, berbagai macam olahan snack, tempe, sangkar burung, tekstil, dan lain sebagainya. Banyaknya potensi UMKM tersebut memerlukan adanya optimalisasi di bidang pemasaran guna memaksimalkan pertumbuhan ekonomi. Oleh sebab itu, perlu dilakukan pemberdayaan terhadap pelaku UMKM melalui pelatihan dan pendampingan proses pemasaran produk. Metode dalam penelitian ini terdiri atas pengambilan data menggunakan metode observasi, wawancara, serta pencatatan kemudian pengambilan sampel dengan purposive sampling, sedangkan menganalisis data dengan teknik analisis data deskripsi kualitatif. Program pelatihan dan pendampingan pemasaran digital dihadirkan untuk menjawab permasalahan dan kebutuhan pelaku UMKM di desa setempat. Melalui program ini, keberadaan UMKM dapat diketahui oleh masyarakat luas melalui informasi di Google Maps dan katalog menu yang dapat dibagikan di media sosial. Bagi internal UMKM, pemaparan informasi terkait kontrak kerja sama dan strategi pemasaran mampu menjadi bahan pertimbangan dalam mengelola keuangan UMKM. Adapun sosialisasi mengenai strategi pemasaran diharapkan dapat meningkatkan pemahaman pelaku UMKM terkait langkah-langkah strategi pemasaran serta dapat mengimplementasikan langkah-langkah strategi pemasaran tersebut sehingga produk dapat dipasarkan secara lebih optimal. Melalui program ini, pelaku UMKM dapat mengimplementasikan ilmu dan pengetahuan yang diperoleh, memanfaatkan media sosial untuk meningkatkan pemasaran produk, serta mampu mengelola pemasaran produk secara digital sehingga produk dapat dipasarkan secara lebih optimal.
Investigação de desvios de temperatura na distribuição de vacinas: análise a partir de uma indústria farmacêutica
Authors: Bernardino Castro Samir , Mendes Athayde André Luiz
Published: June 2024

O objetivo deste estudo foi investigar o monitoramento de temperatura adotado na distribuição de vacinas em uma indústria farmacêutica em Minas Gerais e as possíveis causas de excursões de temperatura durante o transporte. Adotou-se uma abordagem multimétodo, combinando métodos qualitativos e quantitativos. Como método qualitativo, realizaram-se entrevistas semiestruturadas em profundidade com trabalhadores responsáveis pelos processos de armazenagem e distribuição das vacinas na fábrica sob análise, incluindo gestores e analistas. Como estratégia quantitativa, levantaram-se dados da indústria concernente a todos os transportes realizados no intervalo de um ano, a fim de explorar percentuais de desvios de temperatura e de outras variáveis. O estudo permitiu levantar reflexões que podem servir como inputs para ajustes operacionais e estratégicos pelos gestores desta empresa e de outras organizações que também trabalham com operações de distribuição de produtos sensíveis à temperatura, farmacêuticos ou não.
‘My Most Tricky Pickle!’ Balancing Reading Instruction in Play-Based Kindergarten: Educator Self-Efficacy Beliefs and Pedagogical Content Knowledge Needs
Authors: Messenger Yvonne , Gallagher Tiffany L.
Published: June 2024

Many kindergarten educators grapple with how best to teach reading in play-based kindergarten classrooms. The purpose of this mixed-methods study was to ascertain the instructional strengths and needs of kindergarten educators as they teach reading in play-based programs. Fifteen kindergarten teachers participated in an online questionnaire and focus group conversations that explored their concepts of self-efficacy and professional content knowledge to gain an understanding of the tensions these educators expressed, and to compare and confirm these with existing literature. Educators felt quite confident that they were effectively weaving foundational reading skills with learning opportunities into authentic experiences throughout the day. They indicated that balancing competing priorities within their programs was a challenge, and that supporting multilinguals and deepening their understanding of how to effectively build oral language and phonological awareness in their students were areas where they wanted to build their professional content knowledge.
Pētījums par Inflantijas muižnieku Juzefu Ježiju Hilzenu un Inflantijas vēstures pētniecības perspektīvas
Authors:   Latvijas Universitātes Vēstures un filozofijas fakultāte, Seliška Edvards
Published: June 2024

The book review evaluates the biography of the Inflantian (Polish Livonian) nobleman (szlachcic), prominent politician of the Polish–Lithuanian Commonwealth in the 18th century, Józef Jerzy Hylzen, written by Łukasz Wróbel, published in 2022. This work is an important contribution to the history of both Poland and Latvia, since it is the first comprehensive research dedicated to a representative of a noble family closely connected with Latvia. The structure of the book is based on the five criteria proving one’s belonging to the informal nobility elite, magnates: the family's ancient origins, education, including European travel (the so-called Le Grand Tour), political activities, property, and lifestyle. This monograph outlines the perspectives for further studies: border in the consciousness of the nobles of Inflantia in the context of politics, religion, and intellectual movements. Wróbel’s work is unique, factually rich, conceptually interesting, and easily readable. It also presents a very useful source of information for any future researchers of Inflanty.
Kristīne Beķere. Latvijas labā: Politiskā darbība trimdā 20. gadsimta 40.–80. gados. Rīga: LU Akadēmiskais apgāds, 2022
Authors:   Latvijas Universitātes Vēstures un filozofijas fakultāte, Cerūzis Raimonds
Published: June 2024

The book Latvijas labā: Politiskā darbība trimdā 20. gadsimta 40.–80. gados (For the Good of Latvia: Political Activities of Latvian Exiles from the 1940s through the 1980s), written by the chief editor of The Journal of the University of Latvia. History (Latvijas Universitātes Žurnāls. Vēsture), historian Kristīne Beķere focuses on the political actions of Latvian exiles in the Western world during the postwar, and especially, Cold War era. The purpose of the study is to provide an overview of the activities of the Latvian exiles related to the protest movement against the occupation and annexation of Latvia by the USSR. The book defines many periods of exiles’ activities. K. Beķere has identified the most important activities for each stage of history and describes them in a chronological order. Thus, for example, the author describes the period of the emergence of exile after the Second World War, the strengthening of exile organisations, and the development of political activities during the escalation period of the Cold War in the 1950s and 1960s, and the period since the 1970s (Cold War relaxation or detente phase), which created new more active forms of exile’s international protest against the occupation of the Baltic. K. Beķere’s book marks the increasing attention in historiography towards the history of the Latvian exiles. In recent years, for example, a voluminous book by the US–Latvian historian Andrejs Plakans has been published. The book For the Good of Latvia is one of the important contributions to systematise both – the information about the political history of the Latvian exile community and its important information work in the world mostly during the Cold War era.
REVISÃO SISTEMÁTICA NA CONFERÊNCIA INTERNACIONAL SOBRE MAPAS CONCEITUAIS: PANORAMA DA ÁREA DE CIÊNCIAS DA NATUREZA
Authors: Kunzler Kathia Regina , Figueira Eliana Peliçon Pereira , Beber Silvia Zamberlan Costa , Kunzler Kelly Karini , Chesca Diellen Soares , Hennrich Junior Elio Jacob , Miranda Polyanna Guimarães e , Tambarussi Carla Melli , Vasata Darlon
Published: June 2024

Com o propósito de aprofundar o entendimento sobre a utilização dos Mapas Conceituais (MC) no ensino de Ciências da Natureza, foi realizado um estudo de Revisão Sistemática (RS), utilizando como base de dados os anais dos anos de 2004, 2006, 2008, 2010, 2012, 2014, 2016 e 2018, da Conferência Internacional sobre Mapeamento Conceitual (CMC). As questões orientadoras da pesquisa foram: i) Qual a predominância das publicações na área de Ciências da Natureza (Química, Física e Biologia)?; ii) Qual o nível de ensino identificado nessas publicações?; iii) Qual o principal foco das pesquisas em cada uma das áreas?; iv) Quais referenciais teóricos prevalecem?, e v) Com qual finalidade os MC são utilizados? Inicialmente, 1007 artigos estavam disponíveis para análise, após estabelecidos os critérios de inclusão e exclusão, 142 artigos constituíram o corpus da pesquisa. As análises revelaram predominância das publicações para Ciências e Biologia e uma concentração de pesquisas direcionadas para a formação inicial em comparação à formação continuada. O referencial teórico preponderante nas publicações foi a Teoria da Aprendizagem Significativa (TAS), consolidando-se como a principal referência nas pesquisas que abordam MC. No contexto das Ciências da Natureza, o estudo evidenciou ampla aplicação dos MC como elementos do planejamento de ensino, com destaque para material de avaliação da aprendizagem e estratégia de ensino. Ciências e Biologia se destacaram pela diversidade de utilizações bem como, exclusividade entre as áreas, na utilização dos MC como instrumento de pesquisa. Os resultados sugerem áreas específicas para investigações futuras, particularmente no que diz respeito à formação continuada e aprofundamento nas aplicações dos MC em diferentes contextos educacionais e áreas do conhecimento.
Modifikasi Viskositas Kappa Karagenan Sebagai Gelling Agent Menggunakan Metode Polymer Blend
Authors: Chaerunisaa Anis Yohana , Husni Patihul , Murthadiah Fairuzati Anisah
Published: June 2024

[ Viscosity Modification of Kappa Carrageenan as Gelling Agent Using Polymer Blend Method ]
Gelling agent merupakan zat hidrokoloid yang dapat meningkatkan viskositas dan menstabilkan sediaan gel. Karagenan sebagai salah satu gelling agent memiliki konsistensi yang kaku dan padat. Untuk mendapatkan gel karagenan dengan viskositas yang memenuhi standar suatu gelling agent, tetapi memiliki sifat fisikokimia dan stabilitas yang memenuhi syarat, maka diperlukan modifikasi pada kappa karagenan. Salah satu metode modifikasi gelling agent adalah metode polymer blend. Modifikasi viskositas dari gel karagenan dilakukan dengan mencampurkan kappa karagenan dengan berbagai tipe gelling agent yaitu iota karagenan, carbomer 940, natrium karboksimetilselulosa, natrium alginat, dan gelatin dengan perbandingan 10:90, 20:80, 30:70, 40:60, 50:50. Hasil penelitian menunjukan bahwa modifikasi terbaik yang sesuai dengan standar gel adalah pada campuran gel kappa karagenan : carbomer 940 dengan perbandingan 90:10 dan campuran gel kappa karagenan : natrium karboksimetil selulosa dengan perbandingan 70:30. Percampuran kappa karagenan dengan iota karagenan, carbomer 940, natrium karboksimetil selulosa (NaCMC), natrium alginat dan gelatin mempengaruhi viskositas, sineresis, swelling ratio, kekuatan gel dan kekerasan gel, namun tidak mempengaruhi pH dan rheologi dari gel.
Hybrid Switched-Capacitor-Based Boost DC-DC Converter with Reduced Voltage Stress
Authors: Van Tan Luong , Nguyen Thanh Hai
Published: June 2024

This article presents the new hybrid switched-capacitor-based
transformerless DC-DC converters with a high step-up capability and
common ground features. The proposed converter provides low voltage
stress across semiconductor devices to utilize MOSFETs with lower Rdson
and low voltage ratings. In addition, the diodes in switched-capacitor
cells with low voltage stress can reduce the reverse recovery power loss
of the converter. Thus, the overall efficiency of the proposed converter
can be increased. The converter circuit, operating principle, and design
guideline of the proposed converter are discussed. To confirm the
performance of the proposed converter, a detailed comparison study with
the conventional hybrid switched-capacitor converter is also presented.
Finally, a laboratory prototype with 200 W, 25 V to 200 V is set up to
correct the effectiveness of the proposed converter
APPLICATION OF NEW CRITERIA TO RECLASSIFY A CASE OF MDS-EB AND ERYTHROID PREDOMINANCE WITH COMPLEX KARYOTYPE
Authors: Gantana Ethan , Chapanduka Zivanai Cuthbert , Musekwa Ernest Morongwa
Published: June 2024

This article reports an interesting case of a 63-year-old woman with no
previous medical history who presented with non-specific symptoms and
pancytopenia and was diagnosed with myelodysplastic syndrome with excess
blasts (MDS-EB). The paper provides a detailed description of the
patient’s clinical and laboratory findings, including peripheral blood,
bone marrow aspirate, and trephine biopsy. The report highlights the
differences in the classification of myeloid neoplasms between the
current WHO-HAEM4R (2017), the previous edition (WHO -HAEM4 [2008]),
and the forthcoming WHO-HAEM5 and ICC. The case is significant as it
illustrates the characteristic morphology, diagnostic investigations,
and the importance of comprehensive risk stratification in MDS-EB. The
case reported here has a complex karyotype with five chromosomal
abnormalities, which underlines the poor outcome of this entity. This
article also discusses the proposed change in nomenclature from MDS-EB
to MDS with increased blast percentage (MDS-IB) and ‘myelodysplastic
neoplasm’ replacing the term ‘myelodysplastic syndrome’ in the
forthcoming WHO classification (WHO-HAEM5) and why this case may be
better classified using WHO-HAEM5.
A Neuron–Mast Cell Axis Regulates Skin Microcirculation in Diabetes
Authors: Li Xinran , Yuan Dan , Zhang Peng , Luo Chenglei , Xie Xinyang , Zhang Yue , Wei Zhengqi , Wang Mingyang , Cai Yunqiu , Zeng Yi , Lai Luying , Che Delu , Ling Hao , Shi Shengjun , Zhang Hong-Fei , Wang Fang , Li Fengxian
Published: June 2024

Changes in microcirculation lead to the progression of organ pathology in diabetes. Although neuroimmune interactions contribute to a variety of conditions, it is still unclear whether abnormal neural activities affect microcirculation related to diabetes. Using laser speckle contrast imaging, we examined the skin of patients with type 2 diabetes and found that their microvascular perfusion was significantly compromised. This phenomenon was replicated in a high-fat diet–driven murine model of type 2 diabetes–like disease. In this setting, although both macrophages and mast cells were enriched in the skin, only mast cells and associated degranulation were critically required for the microvascular impairment. Sensory neurons exhibited enhanced TRPV1 activities, which triggered mast cells to degranulate and compromise skin microcirculation. Chemical and genetic ablation of TRPV1+ nociceptors robustly improved skin microcirculation status. Substance P (SP) is a neuropeptide and was elevated in the skin and sensory neurons in the context of type 2 diabetes. Exogenous administration of SP resulted in impaired skin microcirculation, whereas neuronal knockdown of SP dramatically prevented mast cell degranulation and consequently improved skin microcirculation. Overall, our findings indicate a neuron–mast cell axis underlying skin microcirculation disturbance in diabetes and shed light on neuroimmune therapeutics for diabetes-related complications.

Article Highlights
Influence of Tire-Enveloping Model Complexity on High-Frequency Simulations
Authors: Radhakrishnan Girish , Erősdi Zakariás , Rouelle Claude
Published: June 2024

Race tires are subject to high speeds and high vertical loads during cornering. They are also subject to extreme stress when they are driven over high-frequency and low-amplitude curbs, often leading to tire failures.

Research and development by D. C. Davis and P. W. A. Zegelaar has shown that when the tire moves over high-frequency, low-amplitude, and short-wavelength obstacles, it exhibits obstacle-enveloping properties. Tire response over such obstacles includes vertical force variation, longitudinal force variation, and rotational speed variation. Additionally, such road inputs excite tire belt dynamics that include high-frequency modes. Therefore, a single-contact-point model is no longer sufficient to predict tire response over such obstacles.

To better capture the tire obstacle-enveloping behavior, advanced contact patch models such as the tandem-cam model by P. W. A. Zegelaar, the radial–interradial spring model by J. M. Badalmenti and G. R. Davis Jr., and the flexible ring model by S. Gong have been developed. To capture high-frequency tire belt dynamics, the rigid-ring model has been developed by P. W. A. Zegelaar. Previous work combines the rigid-ring model with the tandem-cam model to capture obstacle-enveloping behavior and tire belt dynamics up to 60–100 Hz.

This paper presents a comparative study of different tire–road contact models to simulate high-frequency curbs typically found at racetracks. The curb profile of the Singes corner at the Paul Ricard racetrack is chosen for simulations as it is known to be extremely demanding on the tires, often causing failures. An advanced four-wheel model is used to simulate a race car at high speeds. Metrics to quantify the tire response over these high-frequency curbs are created and an investigation is conducted to quantify the influence of tire model complexity on the metrics.
Voices of Learners: An In-Depth Analysis of Business Process Management Course Experiences
Authors: HKT* Hlaing
Published: June 2024

In Business Process Management (BPM) education, understanding student experiences is paramount for continuous improvement. This research presents an in-depth examination of the BPM course, capturing the voices and perspectives of learners. Through a mixed-methods approach, combining hypothetical rating surveys with qualitative analysis, we explore student feedback to uncover nuanced insights beyond numerical ratings. This research begins with hypothetical ratings provided by students, offering a quantitative foundation for the subsequent qualitative exploration. The analysis reveals common themes, both positive and critical, shedding light on the efficacy of the course structure, teaching methods, and overall learning experience. Students' reflections on practical application, collaboration, and the impact of the course on their understanding of BPM concepts are examined, providing a comprehensive view of the learning journey. By triangulating hypothetical ratings with qualitative insights, the research identifies areas for enhancement and highlights positive aspects that contribute significantly to the learning journey. These findings offer valuable recommendations for refining the BPM curriculum and fostering a more engaging and effective educational environment. The integration of both quantitative and qualitative data ensures a holistic understanding of student experiences, guiding future improvements in BPM education.
O parlamentar José Bernardino Batista Pereira D'Almeida
Authors: Leme Marisa Saenz
Published: June 2024

In this article, the partial political trajectory of José Bernardino Batista Pereira d'Almeida is recovered. As the sole representative of the Province of Espírito Santo in the first two legislatures of the Imperial Chamber of Deputies, in 1828 he was part of the ministerial cabinet formed by Dom Pedro I at the end of 1827, with the appointment of deputies who partially opposed his government to occupy key positions. A figure of the moderate liberal camp, highly active in the Chamber until his appointment to the Ministry, he was later practically ignored in imperial political records and only recently has his name been revisited by historiography. The objective is thus to contribute to the reconstruction of his thinking, aiming to deepen understanding of the political history of that period.
L’eredità dantesca nel lessico italiano e il nuovo Vocabolario Dantesco
Authors: Manni Paola
Published: June 2024

In diesem Beitrag soll vor allem gezeigt werden, dass Dantes Vermächtnis im italienischen Sprachgebrauch noch immer präsent und lebendig ist. Es gibt viele Wörter, Phrasen, Redewendungen, manchmal ganze Zeilen aus dem Gedicht, die in unsere gemeinsame Sprache eingegangen sind und frei zirkulieren, ohne dass man sich ihres Ursprungs bewusst wäre. Studien zum Wortschatz Dantes unter diesem Gesichtspunkt – in „prospektiver Diachronie“ (De Mauro) – sind einerseits recht neu. Andererseits erlaubt die Verfügbarkeit der großen Korpora des Altitalienischen, die die Grundlage des TLIO (Tesoro della lingua italiana delle Origini) bilden, auch eine retrospektive Untersuchung, die deutlich macht, wieviel älterer und heutiger Sprachgebrauch dem Wortschatz Dantes schuldet bzw. worin Innovationen bestehen. Aus der Notwendigkeit heraus, die Analyse von Dantes Wortschatz unter Berücksichtigung dieser Aspekte und unter einem spezifisch lexikographischen Gesichtspunkt durchzuführen, wurde in Florenz von der Accademia della Crusca und der OVI (Opera del Vocabolario Italiano) das neue Vocabolario Dantesco, www. vocabolariodantesco.it, ins Leben gerufen, das im letzten Teil des Artikels beschrieben wird.
«Sei all’ascolto di Deutschradio»
Authors: Nowak Patrick
Published: June 2024

L’articolo si prefigge di presentare il progetto Deutschradio dell’Istituto Culturale Tedesco di Prato e cerca di identificarne alcuni vantaggi didattici nelle lezioni d’italiano. Il testo si concentra sulla realizzazione del progetto nell’ambito di un corso avanzato presso la Johannes-Löh-Gesamtschule nella zona di Colonia in Germania e analizza le valutazioni da parte degli allievi che hanno partecipato al progetto. Durante il progetto, gli allievi hanno dovuto creare delle trasmissioni radiofoniche lavorando su temi specifici. In primo luogo, si analizza l’uso dei media rispetto all’insegnamento delle lingue a scuola. In secondo luogo, si riflette sulle particolarità e sulle possibilità didattiche della radio per poi presentare alcune implementazioni a scuola. Il capitolo 3 introduce il progetto e offre una breve storia dell’idea di base. Nel capitolo 4 vengono presentati alcuni aspetti pratici della partecipazione al progetto come lo storyboard che viene usato soprattutto per la preparazione delle trasmissioni. Infine, la valutazione da parte degli allievi riportata nel capitolo 5 mostra che il progetto ha un notevole potenziale relativo all’aumento della motivazione degli allievi. Inoltre, il progetto può aiutare a migliorare sia le competenze linguistiche che quelle digitali.
Investigation of the friction and deformation behaviour of high-speed brakes
Authors: Schadomsky Magnus , Rauhaus Johann , Blumenthal Lars , Zimmer Detmar , Magyar Balázs
Published: June 2024

Spring-applied brakes are widely used components in industrial drive systems. They provide a braking torque by friction between a mostly organic friction lining and a metallic counter surface. Increasing with decreasing size, they currently achieve speeds of up to 6,000 rpm, which corresponds to a sliding speed in frictional contact of up to 35 m/s. At the same time, there is a trend towards high-speed drives, with speeds of 10,000 rpm and above. So far, little is known about the behaviour of the friction value and torque of conventional spring-applied brakes with low-cost organic friction linings under these operating conditions. For this reason, a test rig was develop - ed that allows testing at sliding speeds of up to 120 m/s with different load inertias. The tests carried out at KAt so far showed that with limited friction work, the conventional spring-applied brake reaches the nominal braking torque at higher sliding speeds.
In addition to thermal overload of the friction lining, plastic deformation of the friction bodies can also permanently disrupt the operating behaviour of brakes operated at high sliding speeds. The plastic deformation of the friction discs manifests itself, for example, in a saucer-like shape of the discafs, leading to a reduction in the air gap and causing unwanted changes in the friction conditions. This paper describes the relationship between friction work and friction coefficient in organic linings and the physical mechanism of the deformation process of the friction discs. Based on these possible measures to reduce deformation are explained.
Pragmatic Equivalence in the Translation of Cultural References from Uzbek into English
Authors: N. Bekmurodova Firuza , Sh. Djumabayeva Jamila , Q. Madiyorova Valida
Published: June 2024

The problem of translating cultural references has been one of the most critical aspects of translation studies in recent years. Due to the complexity and diversity of nations, several issues including cognitive dissonance, misinterpretation of customs and traditions, loss of national color, and omission of national connotations can arise during the translation process. Representation of pragmatic features in the context aids in keeping the core meaning of cultural references in translation. This article highlights possibilities of pragmatic equivalence in translating culture-specific words from Uzbek to English based on a case study of two novels. Furthermore, a new model of implementing pragmatic equivalence has been proposed to cover the cultural gap between the addresser (translator) and the addressee (reader). This model is created based on the theory of equivalence by Baker (2006) and the theory of conversational implicatures by Grice (1989). The obtained results may serve to train professional translators and to increase the quality of translations from Turkic languages into English
CLINICAL CASE OF LAMBERT–EATON MYASTHENIC SYNDROME IN A PATIENT WITH SEVERE ULCERATIVE COLITIS
Authors:   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Gabrusskaya T.V. , Kornienko E.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Revnova M.O. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Ulanova N.B. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Shilova E.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Efet E.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Kuznetsova O.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Makarova E.Yu. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Kondratyev G.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Artemyeva A.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia
Published: June 2024

Authors represent the Russia’s first clinical case description of a pediatric patient with ulcerative colitis whose diagnosis was combined with Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune disorder of neuromuscular junction transmission. The observed case draws specialists’ attention to the complexity of diagnosis and the importance of a multidisciplinary approach in the diagnosis and management of such patients. Another purpose was to increase physicians’ awareness of LEMS thereby reducing the period needed to establishing of the diagnosis, which in its turn improves the prognosis of the course of the disease for patients.
PRIMARY COMBINED IMMUNODEFICIENCY WITH CERNUNNOS PROTEIN DEFICIENCY: CLINICAL CASES AND BIBLIOGRAPHICAL REVIEW
Authors:   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Avedova А.Ya. , Roppelt A.A. ,   Moscow City Clinical Hospital No. 52 of the Moscow Department of Healthcare, Moscow, Russia, Rodina Yu.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Deripapa E.V. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Shcherbina A.Yu. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
Published: June 2024

One of the well-known groups of primary immunodeficiency conditions includes primary immunodeficiencies with impaired DNA repair. Primary immunodeficiencies with impaired DNA repair include immunodeficiency with Cernunnos protein deficiency. Pathogenic biallelic genetic variants in the NHEJ1 gene lead to the development of this immunodeficiency. The Cernunnos protein is involved in the processes of non-homologous DNA repair and V(D)J recombination of T- and B-lymphocyte receptors. In the clinical picture of patients with Cernunnos protein deficiency, the leading manifestations are the following: infectious complications within the framework of combined immunodeficiency, cytopenia, autoimmune complications. Like most primary immunodeficiencies with impaired DNA repair, immunodeficiencies with a defect in the NHEJ1 gene are characterized by a predisposition to the development of malignant neoplasms. The only curative treatment for patients with primary immunodeficiency conditions associated with Cernunnos protein deficiency is allogeneic hematopoietic stem cell transplantation.
POSSIBILITIES FOR THE USE OF PIMECROLIMUS IN THE TREATMENT OF ATOPIC DERMATITIS IN CHILDREN
Authors:   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia, Tamrazova O.B. ,   Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia, Novik G.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia, Tamrazova A.V. ,   FSBI of Additional Professional Education "Central State Medical Academy" with the Office of the President of the Russian Federation, Moscow, Russia, Bagramova G.E. ,   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia, Sukhotina A.G. ,   Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia
Published: June 2024

Atopic dermatitis is a common chronic skin disease that is always accompanied by itching and has a significant impact on the patient's quality of life. The goal of therapy for atopic dermatitis, like any chronic dermatosis, is to achieve stable remission, which, given the nature of the disease, can be achieved with the help of a drug that has anti-inflammatory potential and a high safety profile. The therapeutic options for the use of pimecrolimus in patients with atopic dermatitis are observed in the Article.
SIGNIFICANCE OF MEMBRANE AND MOBILE FATTY ACIDS POOLS IN THE TYPE 1 DIABETES MELLITUS COMPLICATIONS PROGRESSION
Authors:   Siberian State Medical University (SSMU), Tomsk, Russia, Samoylova Yu.G. , Koshmeleva M.V. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Fomina S.V. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Gaun M.S. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Trifonova E.I. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Yun V.E. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Kachanov D.A. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Kudlay D.A. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia,   M.V. Lomonosov Moscow State University, Moscow, Russia,   National Research Center Institute of Immunology of the Russian Federal Biomedical Agency, Moscow, Russia
Published: June 2024

Diabetes mellitus (DM) is one of the fastest growing 21st Century health problems worldwide, including type 1 DM. In the context of the “epidemic” of diabetes among children, taking into consideration the modern possibilities for medical examination and laboratory studies of patients with DM, the diagnosis of risk factors for the development of diabetes and diabetic complications comes to the fore as yet. This bibliographical review represents the current state on the factors influencing the development of type 1 DM and its complications in children and adolescents, including an assessment of the role of fat metabolism and lipids in the pathogenesis of the disease. The data was gathered from databases eLIBRARY.RU, PubMed, Dimensions AI and CyberLeninka for 2001-2023.