bluuebunny/crossref_metadata_2025 huggingface dataset:
Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice
Authors: Fu Siming , Luo Xu , Wu Xuan , Zhang Tongyu , Gu Linggui , Wang Yiying , Gao Meng , Cheng Yuan , Xie Zongyi
Published: November 2020

Oxidative stress and neuronal apoptosis play crucial roles in secondary brain injury (SBI) after intracerebral hemorrhage (ICH). Recently, Nle4-D-Phe7-α-melanocyte-stimulating hormone (NDP-MSH), a synthetic agonist of the melanocortin-1 receptor (Mc1r), has been proved to inhibit neuroinflammatory in several diseases. This study is aimed at exploring if NDP-MSH could reduce oxidative stress and neuronal apoptosis following ICH, as well as the potential mechanism. A mouse ICH model was induced by autologous blood injection. NDP-MSH was intraperitoneally injected at 1 h after ICH. Mc1r siRNA and PI3K inhibitor LY294002 were administrated to inhibit the expression of Mc1r and phosphorylation of PI3K, respectively. Neurological test, brain water content, enzyme-linked immunosorbent assay (ELISA), terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL), immunofluorescence, and Western blot analysis were utilized in this study. The results exhibited that Mc1r was mainly expressed in neurons, and its level in the ipsilateral hemisphere was significantly elevated after ICH. NDP-MSH treatment significantly attenuated the neurological deficits and brain water content 24 hours after ICH, which was accompanied by the inhibition of oxidative stress and neuronal apoptosis. The administration of NDP-MSH after ICH significantly promoted the expression of Mc1r, p-PI3K, p-Akt, and p-Nrf2, followed by an increase of Bcl-2 and reduction of cleaved caspase-3. Conversely, downregulating the expression of Mc1r and phosphorylation of PI3K aggravated the neurological deficits and brain edema at 24 hours after ICH, meanwhile, the effect of NDP-MSH on the expression of Mc1r, p-PI3K, p-Akt, p-Nrf2, Bcl-2, and cleaved caspase 3 was also abolished. In conclusion, our data suggest that the activation of Mc1r by NDP-MSH ameliorates oxidative stress and neuronal apoptosis through the PI3K/Akt/Nrf2 signaling pathway after ICH in mice.
Foundation Treatment Assessment and Postconstruction Settlement Prediction of a Loess High Fill Embankment: A Case Study
Authors: Zhu Caihui , Zhou Xiaosong , Wang Songhe
Published: November 2020

The design of high fill embankments (HFEs) on the loess plateau requires proper foundation treatment methods and reasonable prediction of postconstruction settlement (PCS). In situ tests were carried out on a test section of the collapsible loess foundation of a high fill airport to assess the reinforcement effects of common treatment methods. Based on in situ monitored data, the spatial-temporal variations of the PCS of the HFE were investigated, with a simple empirical formula proposed for PCS prediction. The PCS increases linearly with the fill thickness, and the PCS rate varies exponentially with the fill rate. Two engineering recommendations were made to reduce differential PCS and water damage for the test site. The first is to combine the reinforcement methods to reduce PCS of the HFE, i.e., dynamic compaction for loess foundation with lower water content and gravel piles with stabilizers for that with higher water content. The second is to employ the dynamic compaction (DC), percussive compaction (PC), and vibration compaction (VC) to strengthen the fill to reach an average compaction degree above 0.93 and a water content close to the optimal.
The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy
Authors: Sha Wenjun , Wen Song , Chen Lin , Xu Bilin , Lei Tao , Zhou Ligang
Published: November 2020

Diabetic retinopathy (DR) is one of the most serious complications of diabetic microangiopathy. DR has an early onset and is not easy to detect. When visual impairment occurs, the optimal period for therapy is often missed. Therefore, the prevention and treatment of DR should start from the early stage of diabetes. Sodium-dependent glucose transporter 2 inhibitor (SGLT2i) is a new antidiabetic drug which is mainly used in clinical practice to control blood glucose of patients with type 2 diabetes prone to develop chronic heart failure. Recent studies have found that SGLT2 is also expressed in the human retina. Now, the prevention and treatment of diabetic retinopathy with SGLT2i while reducing blood sugar has become a new research field. Hence, this article reviewed the recent therapeutic and research progress of SGLT2 in the treatment of diabetic retinopathy.
Accurate Recognition and Simulation of 3D Visual Image of Aerobics Movement
Authors: Fan Wenhua , Min Hyun Joo
Published: November 2020

The structure of the deep artificial neural network is similar to the structure of the biological neural network, which can be well applied to the 3D visual image recognition of aerobics movements. A lot of results have been achieved by applying deep neural networks to the 3D visual image recognition of aerobics movements, but there are still many problems to be overcome. After analyzing the expression characteristics of the convolutional neural network model for the three-dimensional visual image characteristics of aerobics, this paper builds a convolutional neural network model. The model is improved on the basis of the traditional model and unifies the process of aerobics 3D visual image segmentation, target feature extraction, and target recognition. The convolutional neural network and the deep neural network based on autoencoder are designed and applied to aerobics action 3D visual image test set for recognition and comparison. We improve the accuracy of network recognition by adjusting the configuration parameters in the network model. The experimental results show that compared with other simple models, the model based on the improved AdaBoost algorithm can improve the final result significantly when the accuracy of each model is average. Therefore, the method can improve the recognition accuracy when multiple neural network models with general accuracy are obtained, thereby avoiding the complicated parameter adjustment process to obtain a single optimal network model.
Comparison of MTA, CEM Cement, and Biodentine as Coronal Plug during Internal Bleaching: An In Vitro Study
Authors: Zarean Paridokht , Zarean Parichehr , Ravaghi Arash , Zare Jahromi Maryam , Sadrameli Mitra
Published: November 2020

Background. Internal bleaching is a choice of treatment in discolored endodontically treated teeth. Cervical root resorption is one of the important complications of this treatment. A suggested procedure to prevent this type of resorption is using a coronal barrier under the bleaching materials. The aim of the study was to compare the microleakage of mineral trioxide aggregate (MTA), calcium-enriched mixture (CEM) cement, and Biodentine. Materials and Methods. In this in vitro study, a total of 60 single canal incisors were included. They were randomly divided into three experimental groups (n = 16), one positive control group (n = 6), and one negative control group (n = 6). Coronal portion of the canals in the experimental groups was sealed with 3 mm of MTA, CEM cement, or Biodentine as a coronal barrier. After 3 days, specimens were bleached. A fresh Enterococcus faecalis suspension was added to the samples. The culture tubes were observed for 45 days, and the daily turbidity was recorded. Statistical analysis was accomplished by the Kaplan–Meier test and SPSS 22. Results. All positive samples showed turbidity, whereas none of the negative samples allowed bacterial leakage. Results showed no significant difference between MTA, CEM cement, and Biodentine groups. (

P

value = 0.304, 0.695, and 0.217). The bacterial microleakage for the two groups also did not show significant differences. Conclusions. CEM cement and Biodentine showed promising results as coronal plug, and clinical studies are needed to test these materials with MTA for avoiding microleakage in internal bleaching treatment.
Twelve-Year-Old Girl with Acute Macular Neuroretinopathy: A Multimodal Retinal Evaluation
Authors: Nakayama Luis Filipe , Kase Camila , Bergamo Vinicius Campos , de Moraes Nilva Simeren Bueno
Published: November 2020

We report a 12-year-old female patient with acute macular neuroretinopathy assessed with multimodal retinal exams. Initial fluorescein angiogram and optical coherence tomography angiography (OCT-A) were both normal, and after 4 months OCT-A showed abnormal vascular flow with normal flow in superficial retina layers, choroid, and choriocapillaris.
Myocardial Tissue Reverse Remodeling After Guideline-Directed Medical Therapy in Idiopathic Dilated Cardiomyopathy
Authors: Xu Yuanwei , Li Weihao , Wan Ke , Liang Yaodan , Jiang Xincheng , Wang Jie , Mui David , Li Yangjie , Tang Siqi , Guo Jiajun , Guo Xinli , Liu Xiumin , Sun Jiayu , Zhang Qing , Han Yuchi , Chen Yucheng
Published: November 2020

Background:

The prognosis of patients with idiopathic dilated cardiomyopathy (DCM) has improved remarkably in recent decades with guideline-directed medical therapy. Left ventricular (LV) reverse remodeling (LVRR) is one of the major therapeutic goals. Whether myocardial fibrosis or inflammation would reverse associated with LVRR remains unknown.

Methods:

A total of 157 prospectively enrolled patients with DCM underwent baseline and follow-up cardiovascular magnetic resonance examinations with a median interval of 13.7 months (interquartile range, 12.2–18.5 months). LVRR was defined as an absolute increase in LV ejection fraction of >10% to the final value of ≥35% and a relative decrease in LV end-diastolic volume of >10%. Statistical analyses were performed using paired
t
test and student
t
test, logistic regression analysis, and linear regression analysis.

Results:

Forty-eight (31%) patients reached LVRR. At baseline, younger age, worse New York Heart Association class, new-onset heart failure, lower LV ejection fraction, absence of late gadolinium enhancement, lower myocardial T2, and extracellular volume were significant predictors of LVRR. During the follow-up, patients with and without LVRR both showed a significant decrease of myocardial native T1 (LVRR: [baseline] 1303.0±43.6 ms; [follow-up] 1244.7±51.8 ms; without LVRR: [baseline] 1308.5±80.5 ms; [follow-up] 1287.6±74.9 ms, both
P
<0.001), matrix and cellular volumes while no significant difference was observed in T2 or extracellular volume values after treatment.

Conclusions:

In patients with idiopathic DCM, the absence of late gadolinium enhancement, lower T2, and extracellular volume values at baseline are significant predictors of LVRR. The myocardial T1, matrix, and cell volume decrease significantly in patients with LVRR after guideline-directed medical therapy.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: ChiCTR1800017058.
Consistent Transcription and Translation of Speech
Authors: Sperber Matthias , Setiawan Hendra , Gollan Christian , Nallasamy Udhyakumar , Paulik Matthias
Published: November 2020

The conventional paradigm in speech translation starts with a speech recognition step to generate transcripts, followed by a translation step with the automatic transcripts as input. To address various shortcomings of this paradigm, recent work explores end-to-end trainable direct models that translate without transcribing. However, transcripts can be an indispensable output in practical applications, which often display transcripts alongside the translations to users.

We make this common requirement explicit and explore the task of jointly transcribing and translating speech. Although high accuracy of transcript and translation are crucial, even highly accurate systems can suffer from inconsistencies between both outputs that degrade the user experience. We introduce a methodology to evaluate consistency and compare several modeling approaches, including the traditional cascaded approach and end-to-end models. We find that direct models are poorly suited to the joint transcription/translation task, but that end-to-end models that feature a coupled inference procedure are able to achieve strong consistency. We further introduce simple techniques for directly optimizing for consistency, and analyze the resulting trade-offs between consistency, transcription accuracy, and translation accuracy. 1
Active space of grasshopper mouse vocalizations (Onychomys) in relation to woody plant encroachment
Authors: Green Dana M. , Mull Nathaniel , Scolman Tucker , Griffiths Grace , Pasch Bret
Published: November 2020

The efficacy of animal acoustic communication depends on signal transmission through an oft-cluttered environment. Anthropogenic-induced changes in vegetation may affect sound propagation and thus habitat quality, but few studies have explored this hypothesis. In the southwestern United States, fire suppression and cattle grazing have facilitated displacement of grasslands by pinyon-juniper woodlands. Northern grasshopper mice (Onychomys leucogaster) inhabit regions impacted by juniper encroachment and produce long-distance vocalizations to advertise their presence to conspecifics. In this study, we coupled acoustic recordings and electrophysiological measurements of hearing sensitivity from wild mice in the laboratory with sound transmission experiments of synthesized calls in the field to estimate the active space (maximum distance that stimuli are detected) of grasshopper mouse vocalizations. We found that mice can detect loud (85 dB SPL at 1 m) 11.6 kHz vocalizations at 28 dB SPL. Sound transmission experiments revealed that signal active space is approximately 50 m. However, we found no effect of woody plant encroachment on call propagation because juniper and woody plant density were inversely associated and both present barriers to a 9 cm mouse advertising at ground level. Our data indicate that woody plant encroachment does not directly impact the efficacy of grasshopper mouse communication, but vegetation shifts may negatively impact mice via alternative mechanisms. Identifying the maximum distance that vocalizations function provides an important metric to understand the ecological context of species-specific signalling and potential responses to environmental change.
Searching for a Dialogue
Authors: Delle Donne Carlo
Published: November 2020

The paper aims to examine the linguistic relationship between patients and physicians in the context of the therapeutic relationship. It focuses on the Hippocratic treatises and offers a detailed commentary of a controversial passage of Ancient Medicine par. 2.3. The dialogical model of Ancient Medicine is found to be centred on the patient’s experience; this same idealized model of relation is documented in Plato’s Laws. In the second part of the article the author examines some linguistic peculiarities of medical discourse, such as the use of comparisons and metaphors, and a passage from Galen’s On the Affected Parts that reports the case of a young patient and the difficulties inherent in the dialogue between patient and physician.
Proletarian and Revolutionary Literature in a Transnational Perspective (1920–1940)
Authors: Glinoer Anthony
Published: November 2020

Simultaneously an emblematic and ambiguous case of engaged literature, proletarian and revolutionary writings from 1920–1940 have been the focus of numerous studies: whether they be in Germany, France, the United States or Soviet Russia, the principal actors have been identified, certain works have been republished, and the ways in which these movements were first encouraged and then dismantled by the Communist International in the interest of the only accepted socialist realism have been demonstrated. However, the transnational and even global dimensions of this movement and the profound similarities among institutional processes carried out in different countries have been overlooked. Drawing on little-known critical sources from the Francophone world, this article reworks the terrain and presents the state of institutional sites of proletarian and revolutionary literature. To this end, small groups, magazines, and associations will be considered in order to shed new light on this era when, across the globe, workers turned into writers.
Kierkegaard lesen, gegen und mit Adorno – Von der objektlosen Innerlichkeit zur Selbstbesinnung durch das Andere / From Objectless Inwardness to Self-reflection through the Other
Authors: Yoshida Keisuke
Published: November 2020

Søren Aabye Kierkegaard’s thought has often been regarded as a philosophy of inwardness, especially within the German-speaking world. Theodor W. Adorno takes an ambivalent attitude toward this view: He criticizes Kierkegaard’s conception of subjectivity as ‘objectless inwardness’, while pointing to its potential for self-reflection that enables the subject to recognize its relationship to the outside world. Beginning from this ambivalent interpretation, this study aims to read Kierkegaard against and with Adorno. First, it clarifies that Kierkegaard does not remain in a closed ‘objectless’ conception of inwardness. Second, it explores how Kierkegaard conceives of inward self-reflection on remorse for sin, which is brought about through the ‘other’ and makes the subject confront its own reality. Thus, Kierkegaard’s concept of inwardness not only overcomes its objectlessness, but also implies a subjective self-reflection through the ‘other’, which can lead to social critique.
Effect of Nano-Platinum on Proliferation and Apoptosis of Non-Small Cell Lung Cancer Cells via P53 Pathway
Authors: Liu Yiqun , Hu Fangjuan , Zhao Long
Published: November 2020

This paper studies the non-small cell lung cancer with interventional treatment of polyethylene imine-coated platinum nanoclusters. The relationship between the inhibition of non-small cell lung cancer cell proliferation, apoptosis, and the expression of its related apoptotic protein
p53. Apoptosis experiments were applied was used to detect the effect of nanoplatin on A549 cells. Western blot was used to detect the expression of p53 protein in A549 cells after nanoplatin treatment. We co-cultured nanoplatin with cells for 4 hours and performed nuclear staining. Observed
by laser confocal microscopy, we found that nanoplatin can enter the nucleus and cytoplasm of non-small cell lung cancer A549 cells, and the phenomenon of drug entering the nucleus is very obvious. Treatment of non-small cell lung cancer with A549 cells at different concentrations of nanoplatin
for 24 hours, with the increase of the concentration, the proliferation inhibition rate of non-small cell lung cancer gradually increased. Treatment of cisplatin-resistant non-small cell lung cancer cells with different concentrations of nanoplatin for 24 hours, as the concentration increases,
the proliferation inhibition rate of non-small cell lung cancer gradually increases. After treatment of A549 cells with different concentrations of nanoplatin for 24 hours, the apoptosis rate of A549 cells gradually increased with the increase of drug concentration. Finally, we conclude that
nanoplatin has not only inhibitory and pro-apoptotic effects on non-small cell lung cancer cells, but also fluorescent labeling. Compared with cisplatin, nanoplatin can significantly inhibit the proliferation of non-small cell lung cancer cells and overcome its cisplatin resistance. The p53-related
signaling pathway may participate in the process of apoptosis and reverse the process of cisplatin resistance, but the specific mechanism and whether there are other signaling pathways involved Further research is needed.
Explore the Effects of Fe3O4 Nanoparticles and Oxidative Stress and Neuroinflammatory Responses on the Intestinal Flora Based on a Parkinson Rat Model
Authors: Xu Li , Mayila Tuexun , Wang Jie
Published: November 2020

Parkinson’s disease is a degenerative disease of the central nervous system, and it occurs in middle-aged and elderly people. Studies have shown that both the clinical symptoms and neuropathological evidence of Parkinson’s disease suggest that Parkinson’s disease may
originate in the gut. Intestinal flora homeostasis plays an important role in maintaining normal functions of the brain and nervous system. It participates in changes in cellular flora through oxidative stress, inflammatory response, and immune response during metabolism. Intestinal flora
disorders are closely related to the onset of neurological diseases such as Parkinson’s disease (PD). In order to better understand the relationship between intestinal flora and Parkinson’s disease, this article studies the correlation between PD rat models and intestinal flora,
and analyzes the possible relationship between them. The 6-OHDA PD rat model is currently a better model preparation method, which is widely used in PD research. The experimental results show that using Fe3O4 nanoparticle technology to detect intestinal flora disorders
in PD patients, and the role of intestinal flora disorders in Parkinson’s disease may include affecting inflammatory response and oxidative stress, α-synuclein Protein (α-syn), these modes of action are not independent, there are complex and synergistic effects,
and the molecular simulation mechanism may play a key role in these effects. There is a certain relationship between intestinal flora and Parkinson’s disease, but the specific mechanism is not clear, and further research is needed to provide more directions for the early diagnosis and
early treatment of PD.
Preparation of AuNPs/SF Nanofibers and Its Ability to Inhibit Tumor Growth in Breast Cancer-Bearing Animal Models
Authors: You Guangning , Xu Shuping , Yao Xingfei , Wu Huanhuan , Shi Yingying
Published: November 2020

Silk fibroin was used as a stabilizer for gold nanoparticles, and a direct silk fibroin-gold nanoparticle composite system was prepared by a direct compounding method in this paper. The stability of Au NPs/SF in phosphate buffer solution with different pH and KCl concentration was studied.
The Au NPs/SF system was characterized by UV-visible light spectrum, transmission electron microscope and infrared spectrum. The silk fibroin-gold nanoparticle composite system was prepared by in situ reduction of chloroauric acid with silk fibroin, according to the change of solution
color and the change of ultraviolet absorption peak. The effects of exogenous factors on the stability of the silk fibroin-gold nanoparticle in situ composite system were initially discussed, and its inhibition in breast cancer-bearing animal models was studied. In vivo experiments
show that in situ injection of Au NPs/SF nanofibers and treatment with light can effectively control tumor growth. Compared with monodisperse gold nanoparticles, silk fibroin-gold nanoparticles can kill tumor cells and inhibit tumor tissue growth more effectively.
Mouse Model to Explore the Therapeutic Effect of Nano-Doxorubicin Drug Delivery System on Bladder Cancer
Authors: Liu Bing , Gao Xiaosong , Han Bing , Chen Guohong , Song Shuqi , Bo Hai
Published: November 2020

To study the therapeutic effect of nano-dosin-loaded drug system in mouse bladder cancer, a luciferase-labeled mouse bladder cancer cell line and a mouse bladder cancer model were constructed. In vivo imaging monitors tumor growth and uses a combination of photothermal, immune,
and chemotherapy to treat the mouse model. With doxorubicin as an antitumor drug carrier, the drug loading, in vitro drug release, cytotoxicity and behavior in cells of mesoporous nano particle-targeted drug delivery system were studied. The cells were injected into the bladder through
the urethra, and the mouse bladder cancer subcutaneous model was treated with gelatin-coated single-walled carbon nanotube-encapsulated mouse granulocytes-macrophage colony-stimulating factor and doxorubicin. In the process of using, the use of near-infrared light for irradiation, thereby
achieving the combined effect of photothermal, immune and chemotherapy. The experimental results show that the prepared doxorubicin prodrug delivery system can enhance the targeted therapeutic effect and reduce the toxicity and side effects of the drug. Especially for those cancer cells or
tissues with overexpression of folate receptors, it has a better therapeutic effect and provides reference for the treatment of subsequent bladder cancer.
Preparation of Galactosyl Nanoparticles and Their Targeting Efficiency to Hepatocellular Carcinoma
Authors: Liao Wei , Tang Yan , Hu Zhengcui , Wang Chunyan , Chen Yi , Zhang Yi , Fan Wenhan
Published: November 2020

Liver diseases seriously endanger people’s physical health, especially liver cancer, and its morbidity and mortality have increased year by year. The reason why liver cancer is difficult to cure is that in addition to the low lethality of cancer drugs to cancer cells, another
important factor is that the drugs do not have liver targeting, and there is no way to efficiently deliver anti-cancer drugs to the liver lesions. Hepatocytes can specifically recognize galactose, therefore the galactosyl liver-targeted drug carrier can deliver the drug to the liver in a targeted
manner, so that the drug can be directed to the liver, reduce the dose and times of drug administration, reduce toxic side effects, and reduce the adverse reactions of patients, which is of great significance for the treatment of liver cancer. In this thesis, paclitaxel long-circulating nano-liposomes
targeting liver cancer constructed with galactose as raw materials can improve the pharmacokinetics and tissue distribution of traditional formulations of paclitaxel, and enhance the safety and tumor suppressive effect of paclitaxel in vivo.
Injection of Carbon Nanoparticles for Lymph Node Detection After Laparoscopic Colorectal Cancer Surgery
Authors: Wang Donghua , Chen Manyu , Lv Long , Chen Yu , Tian Kui
Published: November 2020

Colorectal cancer is the third most common cause of cancer-related death in the world because of its poor prognosis and many related complications. In clinical practice, lymph node metastasis is an important index to evaluate the recurrence and survival rate of patients with rectal
cancer, it also the main method to determine the treatment plan of patients with rectal cancer. Nano carbon tracer can guide surgeons to clear regional lymph nodes accurately, improve the number of lymph nodes detected, and then improve the accuracy of pathological staging of rectal cancer.
It has an important clinical significance in the removal of lymph nodes of middle and low rectal cancer, and provides an important basis for the development of postoperative adjuvant treatment plan. The purpose of this study is to explore the application value of this method in improving the
detection rate of lymph nodes in laparoscopic colorectal cancer. According to the research results, the total number of lymphatic gland, the number of small lymphatic gland, the rate of lymph node metastasis, the number of black stained lymphatic gland and the number of lymphatic gland confirmed
by pathology in the two groups were better than those in the traditional surgical treatment, which had better application value in the radical operation of colorectal cancer.
Influence of Nanoparticle-Loaded Edaravone on Postoperative Effects in Patients with Cerebral Hemorrhage
Authors: Dang Lianfeng , Dong Xin , Yang Jie
Published: November 2020

In order to explore the influence of nanoparticle-loaded edaravone on postoperative effects in patients with cerebral hemorrhage, a total of 120 patients who were diagnosed as cerebral hemorrhage and underwent minimally invasive hematoma removal at the designated hospital by the study
from December 2014 to December 2018 were selected as research objects and divided into three groups according to the random number table method: edaravone treatment (ET) group, nanoparticle-loaded edaravone treatment (NET) group, and combined treatment (CT) group with 40 patients in each group.
Three groups of patients underwent routine treatments based on their conditions, including regulating blood sugar, regulating blood pressure, anti-infection, nutritional support, and managing complications, in which 25 mg edaravone injection and 100 ml saline were added for patients in NET
and CT group on the basis of the routine treatment of patients in ET group. The results showed that, after 15 days of standard treatment, the 40 patients in NET group had significantly improved neurological function than that before the treatment; the secretion of inflammatory factors in peripheral
serum increased on the 7th day of treatment and decreased on the 14th day of treatment; there was no statistically significant difference in edema volume before treatment and the edema volume in the NET group was (11.56±0.44) mL after treatment, which was significantly smaller than
that in ET group of (14.63±1.15) mL and the difference between the three groups was statistically significant (P <0.05). Therefore, it is believed that nanoparticle-loaded edaravone has an important effect on the postoperative effect of patients with cerebral hemorrhage; it
can significantly improve the neurological function of patients with cerebral hemorrhage after minimally invasive drainage, and obviously reduce the production and release of interleukin and tumor necrosis factor, which is beneficial to protect healthy brain tissue and other organs throughout
the body, and is conducive to the recovery and healing of cerebral hemorrhage. The results of this study provide a reference for further research on the influence of nanoparticle-loaded edaravone on postoperative effects in patients with cerebral hemorrhage.
The Role of Tacrolimus Nanomicelles in Acute Rejection After Liver Transplantation in Rats
Authors: Xie Zhantao , Zhao Huibo , Chen Yuan , Wei Sidong , Sun Jianjun , Tang Gaofeng , Wang Weiwei , Chen Guoyong
Published: November 2020

Although there is some progress in immunosuppressive therapy of acute rejection, there is still a lack of standardized diagnosis and treatment. For the acute rejection after liver transplantation, there is still a lack of an exact treatment at this stage. Tacrolimus (TAC) side effects
will also affect the survival rate and quality of life of recipients after transplantation to a large extent. Rat orthotopic liver transplantation model was established and divided into three groups. In the tolerance group, Brown Norway (BN) to Lewis liver transplantation was used; in the
rejection group, Lewis to BN liver transplantation was used; in the TAC group, TAC was injected after operation on the basis of establishing rejection model. The expression of GITRL in Kupffer cells and the change of cytokines were detected 7 days after operation. In this study, the animal
model of acute rejection of rat liver transplantation was established to simulate the clinical allogeneic liver transplantation, and the important role of TAC in the acute rejection of rat liver transplantation was evaluated.
Research on the Treatment of Diabetic Foot with Ulcer Based on Nano-Silver Antibacterial Dressing
Authors: Yang Lumeng , Liu Fang , Chen Yijun , Liu Zhangyi , Zhang Guowu
Published: November 2020

The incidence of diabetes has been increasing year by year. Long-term growth in blood sugar causes complications such as diabetic foot ulcer and infections, which will increase the difficulty of ulcer treatment. The diabetes brings great pain and heavy economic burden to patients and
their families. In view of the above problems, a nano-silver antibacterial dressing is synthesized in this paper to control bacterial infection on the ulcer surface and promote wound healing. This paper describes the preparation process and morphological characterization of nano-silver antibacterial
dressings. 100 patients were selected, which divided into two groups for comparative experiments. The conventional group used conventional vaseline dressing, and the control group was nano-silver antibacterial dressing. The ulcer surface healing time, the number of dressing changes, and the
control of infection were analyzed separately, and statistical analysis was performed with SPSS19.0. The experimental results are as follows. The use of nano-silver antibacterial dressing can significantly reduce the incidence of infection in diabetic foot patients, which is helpful to reduce
the number of dressing changes, shorten the healing time of ulcer, and accelerate the turnover rate. It helps to shorten the course of diabetic foot, and it is recommended to promote its clinical application.
Applied Research Glass Ionomer Cement with TiO2 Nanoparticles in Orthodontic Treatment
Authors: Ren Jiajie , Du Zhen , Lin Jiang
Published: November 2020

In orthodontics treatment, scholars have tried to introduce nano antibacterial materials into the materials used in orthodontics to reduce the occurrence of enamel demineralization, caries and periodontitis. The experiment investigated the effect of adding titanium dioxide nanoparticles
in different proportions on the flexural strength, compressive strength, surface hardness, tribological properties, adhesion properties, fluorine release properties and antibacterial properties of glass ionomer cement. The effect of water cement on orthodontics, the experiment added different
proportions of titanium dioxide nanoparticles to traditional glass ion cement, which greatly improved the mechanical strength of glass ion cement, and significantly improved the antibacterial effect of glass ion cement, bending strength, compressive strength and surface hardness. The addition
of titanium dioxide nanoparticles produced a significant antibacterial effect on Streptococcus mutants. Nano-TiO2 glass ionomer cement has a significant effect on orthodontics, and the damage to patients’ teeth is significantly lower, which is worthy of clinical popularization.
Study on the Mechanism of Targeted Poly(lactic-co-glycolic acid) Nano-Delivery Carriers in the Treatment of Hemangiomas
Authors: Liao Sheng , Wu Jiawen , Li Zhituo , Cheng Guobing , Lu Baitao , Liu Guojun , Li Xiaoyang , Lu Wei
Published: November 2020

Hemangiomas, also called infantile hemangiomas (IH), are the most common congenital benign vascular tumors in infants and young children. At present, there are many treatment methods for proliferative hemangiomas, which have different effects and lack predictability. Propranolol has
gradually replaced glucocorticoids as the first-line treatment for infants and young children with hemangiomas. However, premature discontinuation is prone to relapse, and the efficacy and safety of medication need to be further studied and determined. The exact pathogenesis of hemangiomas
is still unclear. Therefore, in this study, poly(lactic-co-glycolic acid) (PLGA) nanoparticles were used as drug delivery carriers, propranolol was encapsulated, and PLGA-propranolol (PLGA-PP) nanodelivery preparations were prepared and targeted. Anisotropy and pharmacokinetics were preliminary
studied. At the same time, after the treatment of HemECs cells with PLGA-PP in gradient concentration in vitro, CCK-8 method was used to detect the cell proliferation, and Anyixin-V/PI double staining method was used to detect the apoptosis rate of cells. The effect of PLGA-PP nano-delivery
vector on hemangioma was studied by western blot method to detect the expression level of Id-1 protein in HemECs. The results showed that after PLGA-PP treated HemECs for 24 h, PLGA-PP significantly inhibited HeECs proliferation and promoted their apoptosis, and the intracellular Id-1 protein
expression was also reduced. Therefore, this study believes that the mechanism of PLGA-PP nano-targeted delivery preparations in the treatment of hemangiomas is achieved by down-regulating the Id-1 gene, thereby inhibiting the colonization of HemECs and promoting its apoptosis effect.
Preparation of Isorhamnetin Nanoparticles and Their Targeting Efficiency to Nasopharynx Cancer
Authors: Yang Bo , Zhang Fang , Yuan Weili , Du Li , Jiang Xuejun
Published: November 2020

Cancer is a serious threat to human health and longevity, and is an important cause of disease death. At present, cancer is mainly treated by surgery, radiotherapy, chemotherapy, etc. The existing various methods of treating tumors have their limitations. Although there are immune,
genetic and other treatment methods, they are still immature. Therefore, tumor-targeted drug delivery systems have attracted more and more attention in cancer treatment. Targeted nano-drugs are selectively targeted to the tumor surface to achieve targeted drug delivery. New nano-drugs have
created new hotspots in medical research. It could be a new strategy for treating cancer. Carboxymethyl chitosan (CMC) is formed by the carboxylation of chitosan. It has good water solubility and biodegradability, biocompatibility and antibacterial properties, so CMC is the best choice as
a nanomaterial. Isorhamnetin (Iso) is an important anticancer drug. This article uses nanomedicine technology to construct CMC as a carrier, Iso as an antitumor drug, and using polydopamine (PDA) to modify the surface of the particles. Through in vitro and in vivo experiments, the Iso/CMC-PDA
nanosphere Targeting and Growth Inhibition of Cervical Cancer Cells.
Application and Research of Nursing Products Based on Single Wall Carbon Nanotubes in Personal Health Care
Authors: Li Xiaowei , Zhao Wenbo , Zhao Dong , Jing Hongyan
Published: November 2020

Single walled carbon nanotubes have special chemical and physical properties, at the same time, they have the advantage of macro maneuverability in maneuverability, so they have the potential of multi-functional applications. At present, composite materials, super capacitors and corresponding
personal care products based on carbon nanotubes are widely used in all aspects of people’s lives, and these products have obvious functional advantages. In this paper, based on the application of single-walled carbon nanotubes technology in personal care products, the separation and
purification of ginsenoside pods, the raw material of high-end washing and care products, was studied. In order to enhance the conductivity and tensile strength of SWNTs, this paper innovatively introduces the purification method of current acid treatment to enhance the performance of SWNTs.
Based on the improved single-walled carbon nanotubes technology, the extraction efficiency of the optimized single-walled carbon nanotubes was analyzed. In the end of this paper, the optimized extraction method of ginsenoside pods from SWNTs is compared with the traditional extraction method.
The experimental results show that SWNTs has obvious time efficiency advantage.
Nanobubble Lung Ultrasound Application in the Treatment of Neonatal Pneumonia
Authors: Zhou Jia , Zhang Qingyu , Zhang Qi , Zhang Zhiyi
Published: November 2020

This article studies the effect of pulmonary ultrasound in the diagnosis and treatment of neonatal pneumonia. In this experiment, 33 children with pneumonia diagnosed and treated in the hospital were selected as the research objects, and all were performed by X-ray examination and lung
ultrasound. After the test was completed, the diagnostic accuracy of the two examination methods was analyzed, the performance of the chest X-rays of the children were observed, and the lung ultrasound examination was recorded at the same time. The results showed that the diagnostic accuracy
of lung ultrasound examination was 93.00%, which was higher than 75.00% of X-ray examination, and the difference was statistically significant (P < 0.05). In the experiment, the paired chi-square test was performed on the results of LUS and bedside CXR diagnosis of IPN, and the value
was 0.687. The two have a good consistency in the diagnosis of IPN in NICU. The Pearson correlation test results of LUS score and neonatal pneumonia case score showed that there was a significant negative correlation between LUS score and neonatal pneumonia case score. The LUS scores between
the control group, non-risk recombination, and risk recombination were tested by rank sum test of multiple independent samples. The results showed that the LUS scores of the three groups were statistically significant (P < 0.05). The LUS scores of the risk recombination were significantly
higher than the non-risk recombination. Two independent sample rank sum tests were performed between each two groups. After Bonferroni correction of P value, the difference between each group was statistically significant. In the end, we have concluded that for the diagnosis of neonatal
pneumonia, pulmonary ultrasound can be used for diagnosis. Combining pulmonary ultrasound with X-rays can improve the diagnosis accuracy of pneumonia. During the treatment, ultrasound is used for dynamic monitoring. By observing the pleural line and pulmonary consolidation it can be used to
clarify the treatment effect of children. LUS and bedside CXR have a good agreement for the diagnosis of IPN. The LUS score can effectively assess the severity of IPN. The greater the severity of the disease in children with IPN, the higher the LUS score.
An Assessment of Concurrency in Evapotranspiration Trends across Multiple Global Datasets
Authors: Kim Seokhyeon , Anabalón Alfonso , Sharma Ashish
Published: November 2020

While broad consensus exists that temperatures are increasing, there is uncertainty surrounding the direction of change manifested in actual evapotranspiration (ET) worldwide. This study assessed trends in ET across the land surface using 11 widely used global datasets for a 32-yr study period. To demonstrate the agreement and disagreement of trends, the spatial distribution, concurrence, correlation, and similitude were estimated. The results showed that while the global average trend in ET is −0.072 mm month−1 yr−1, the trends from individual datasets show a wide range of differences in magnitudes and directions. The considerable differences in the trends in each dataset were found to be weakly correlated with each other and highly divergent in their distribution and direction. No single dataset was sufficiently similar to another to offer a fair representation of trends. In a dynamic trend analysis using a 10-yr moving window over the study period, high concurrence in the significant trends throughout the datasets was found to be rare for each time period. In general, the global data concurrence became negative by 1997 but rebounded to positive toward the end of the study period. In terms of spatial tendency, some regions were more prone to change the direction of their significant trends within the study period. This result shows a high inconsistency in the location and direction of significant ET trends, implying that selection of an ET dataset should consider its spatiotemporal uncertainty before use for any water balance study aiming to infer hydrological change over time.
Subseasonal Forecast of Surface Air Temperature Using Superensemble Approaches: Experiments over Northeast Asia for 2018
Authors: Zhu Shoupeng , Zhi Xiefei , Ge Fei , Fan Yi , Zhang Ling , Gao Jianyun
Published: November 2020

Bridging the gap between weather forecasting and climate prediction, subseasonal to seasonal (S2S) forecasts are of great importance yet currently of relatively poor quality. Using the S2S Prediction Project database, the study evaluates products derived from four operational centers of CMA, KMA, NCEP, and UKMO, and superensemble experiments including the straightforward ensemble mean (EMN), bias-removed ensemble mean (BREM), error-based superensemble (ESUP), and Kalman filter superensemble (KF), in forecasts of surface air temperature with lead times of 6–30 days over northeast Asia in 2018. Validations after the preprocessing of a 5-day running mean suggest that the KMA model shows the highest skill for either the control run or the ensemble mean. The nonequal weighted ESUP is slightly superior to BREM, whereas they both show larger biases than EMN after a lead time of 22 days. The KF forecast constantly outperforms the others, decreasing mean absolute errors by 0.2°–0.5°C relative to EMN. Forecast experiments of the 2018 northeast Asia heat wave reveal that the superensembles remarkably improve the raw forecasts featuring biases of >4°C. The prominent advancement of KF is further confirmed, showing the regionally averaged bias of ≤2°C and the hit rate of 2°C reaching up to 60% at a lead time of 22 days. The superensemble techniques, particularly the KF method of dynamically adjusting the weights in accordance with the latest information available, are capable of improving forecasts of spatiotemporal patterns of surface air temperature on the subseasonal time scale, which could extend the skillful prediction lead time of extreme events such as heat waves to about 3 weeks.
Stepping out of the Shadows: Identity Exposure as a Remedy for Stigma Transfer Concerns in the Medical Marijuana Market
Authors: Khessina Olga M. , Reis Samira , Verhaal J. Cameron
Published: November 2020

Many legalized markets bear categorical stigma—a vilifying label attached to an industry and its participants—that threatens their performance and survival chances. This happens because audiences avoid engagement with stigmatized organizations to minimize the probability of stigma transfer. Although scholars have explored what strategies stigmatized companies undertake to mitigate their stigma, we know very little about whether and how audiences’ acceptance of stigmatized organizations actually happens and if industry-level processes play a role in this acceptance. We develop a theory of identity exposure predicting that customers will become less concerned about stigma transfer when stigmatized organizations unambiguously reveal their identities by publicly advocating and celebrating their business and when vanguard customers openly discuss stigmatized organizations and their products in public forums. We find support for our theorizing in the analyses of customers’ concerns about stigma in Weedmaps.com —a marijuana-based community—from its inception in 2008 through 2014. Ultimately, our findings and extensive robustness checks suggest that identity exposure within stigmatized industries can alleviate customers’ concerns about stigma transfer and in this way accelerate the market destigmatization process.
Who Controls Criminal Law? Racial Threat and the Adoption of State Sentencing Law, 1975 to 2012
Authors: Duxbury Scott W.
Published: November 2020

Threat theory argues that states toughen criminal laws to repress the competitive power of large minority groups. Yet, research on threat suffers from a poor understanding of why minority group size contributes to social control and a lack of evidence on whether criminal law is uniquely responsive to the political interests of majority racial groups at all. By compiling a unique state-level dataset on 230 sentencing policy changes during mass incarceration and using data from 257,362 responses to 79 national surveys to construct new state-level measures of racial differences in punitive policy support, I evaluate whether criminal sentencing law is uniquely responsive to white public policy interests. Pooled event history models and mediation analyses support three primary conclusions: (1) states adopted new sentencing policies as a nonlinear response to minority group size, (2) sentencing policies were adopted in response to white public, but not black public, support for punitive crime policy, and (3) minority group size and race-specific homicide victimization both indirectly affect sentencing policy by increasing white public punitive policy support. These findings support key theoretical propositions for the threat explanation of legal change and identify white public policy opinion as a mechanism linking minority group size to variation in criminal law.