bluuebunny/crossref_metadata_2025 huggingface dataset:
Memoria cotidiana: Dimensiones y pautas de declive en adultos sanos. / Everyday memory: Dimensions and patterns of decline in healthy adults.
Authors: Casado Verdejo Inés , Bárcena Calvo Carmen
Published: November 2017

RESUMENEl objetivo de este trabajo fue validar y conocer las propiedades psicométricas del Cuestionario de Memoria Cotidiana (CMC) inspirado en el Everyday Memory Questionnaire (EMQ) de Baddeley (1997). Se comprobó su fiabilidad y la validez de constructo y se determinaron sus dimensiones a través de su análisis factorial. En un primer momento participaron 129 adultos sin patología cognitiva, de edades comprendidas entre los 48 y los 91 años de edad. En un segundo momento, con una muestra de 510 adultos sanos de edades comprendidas entre los 48 y los 90 años, se quiso saber si existe afectación diferenciada de las distintas dimensiones de memoria cotidiana establecidas. Los resultados permiten concluir que dicha medida pluridimensional posee propiedades psicométricas adecuadas, alfa de Cronbach de .91, y se evidencia que existen sistemas o áreas componentes de la memoria cotidiana diferencialmente resistentes al deterioro. Los fallos cognitivos autoinformados indican que las áreas que más deterioro sufren con el paso de los años son el recuerdo del sitio de las cosas y la memoria de fuente, siendo la más resistente la memoria autobiográfica en ambos sexos.ABSTRACTThe main of this work was to validate and to know the psychometric properties of the Cuestionario de Memoria Cotidiana (CMC) inspired in Baddeley's Everyday Memory Questionnaire (EMQ) (1997). We checked their reliability and construct validity and their dimensions were determined through their factorial analysis. We make, at first, with a sample of 129 adults not suffering from any cognitive pathology and aged between 48 and 91 years. And at a later stage, a sample of 510 healthy adults with ages ranging from 48 and 90 years was used to discover if there were any differentiation of effects in the various dimensions of everyday memory that were established. Results shown that this multi-dimensional measurement has acceptable psychometric properties, with a Cronbach’s alpha of 0.91, and also provided evidence that there are systems or areas making up every-day memory that are differentially resistant to deterioration. Self-reported cognitive failures indicated that the areas suffering most downgrading with the passage of time are recall of the location of objects and source memory, with autobiographic memory being more resistant in both sexes.
Harmoni dan Narasi Kosmos
Authors: Prabawa Wiguna Iqbal
Published: November 2017

For all his life Johannes Kepler seeking for harmony. Kepler is best known for his laws of planetary movement. He is also a polymath working in the intersection between contemporary sciences such as astronomy, math, physics, optics, astrology, music theory, meteorology dan history. After spending years exploring those different disciplines, he later learned he was actually longing for the harmony. His fascination over harmony in nature kept growing up, in his last days Kepler was still trying to finish a book he started since he was still a scholar. This book is called Somnium. Somnium itself is the Latin word for 'dream,' a word that make sense if you read the whole chapter. The main idea for this project is Kepler’s fascination over the harmony in celestial object, thus he tried to convince people that Copernicus heliocentrism is the absolute truest way to understand how our solar system works. The idea of making narative came up to Kepler’s mind as he turned his research into a fiction, a story about a boy who makes his journey to the moon to help his mother for being accused of being a witch. Similiarly to the boy, Kepler’s mother is also accused for witchcraft. So Somnium was not really just a scientific book but in some part of them, there is also some biographical facts and fiction. By knowing the pattern in nature we can understand that the nature is in order and there is a grand design hidden in layers. Just like Kepler that are fascinated by the order of nature, 'Somnium' in this work is also talks about the pattern and harmony the curiousity for nature that represented in geometrical objet and natural study, and also about the old knowledge where science, art and spirituality is learnt through one form knowledge
Media Pembelajaran Bahasa Arab untuk Siswa Madrasah Ibtidaiyah
Authors: Sukamto - , Elfizar - , Asriyani -
Published: November 2017

Penelitian ini membahas tentang media pembelajaran Bahasa Arab, yaitu alat untuk menyampaikan materi yang digunakan untuk membantu pengajar atau guru dalam menyampaikan sebuah pembelajaran, juga salah satu alternatif untuk mempermudah siswa khususnya siswa Madrasah Ibtidaiyah dalam mempelajari Bahasa Arab.  Pembuatan media pembelajaran Bahasa Arab ini menggunakan Adobe Flash CS4 Proffesional, sedangkan dalam perancangannya menggunakan Storyboard, Struktur Navigasi, dan Flowchart.Hasil pengujian terhadap media pembelajaran ini secara keseluruhan adalah sebanyak 33%  menyatakan Sangat Baik, 29% menyatakan Baik, dan 8% menyatakan Kurang Baik. Ini menunjukkan bahwa lebih dari 60% responden menyatakan media pembelajaran ini sudah berjalan dengan baik. Sedangkan pengujian terhadap tampilan media pembelajaran dapat menarik minat belajar adalah sebanyak 60% menyatakan Sangat Baik, 30% menyatakan Baik, dan 10% menyatakan Kurang Baik. Hal ini menunjukkan bahwa 90% media pembelajaran ini dapat menarik minat belajar.
Implementasi Knowledge base pada Aplikasi Data Orang Hilang (Studi Kasus: Polres Tasikmalaya Kota)
Authors: Meidiyan Mohamad Gibran , Mubarok Husni , Rianto Rianto
Published: November 2017

Pada proses perkembangan suatu teknologi, pengetahuan (knowledge) dan informasi menjadi sangat penting untuk menjadi sumber daya utama yang akan sangat menunjang pada suatu instansi. Kepolisian Resor Tasikmalaya Kota (Polres Tasikmalaya Kota) sebagai suatu instansi pemerintah, mengolah dan mengelola data orang hilang merupakan salah satu tugas Polres Tasikmalaya Kota yaitu pelayanan kepada masyarakat. Sejalan dengan meningkatnya laporan orang hilang di Kota Tasikmalaya, Polres Tasikmalaya Kota membutuhkan suatu sistem yang dapat melakukan identifikasi data orang hilang berdasarkan pengetahuan (knowledge). Tujuan umum dari penelitian ini yaitu mengimplementasikan Knowledge Base pada Aplikasi Data Orang Hilang di Polres Tasikmalaya Kota yang sesuai dengan kebutuhan saat ini. Metode penelusuran yang digunakan pada penelitian ini adalah penelusuran runut maju (forward chaining). Hasil akhir dari penelitian ini adalah sebuah aplikasi yang berjalan sesuai dengan harapan.
"Escribo que escribo": de la metapoesía a las autopóeticas
Authors: Scarano Laura
Published: November 2017

"Escribo que escribo": de la metapoesía a las autopóeticas
Claudio Guillén y la teoría de la novela
Authors: Sullà Enric
Published: November 2017

Claudio Guillén y la teoría de la novela
Cancha y polifonía: la noción de estilo en el cuento «Yo soy Fontanarrosa» de Juan Villoro
Authors: García Cames David
Published: November 2017

Cancha y polifonía: la noción de estilo en el cuento «Yo soy Fontanarrosa» de Juan Villoro
El seductor castigado en la comedia de Bretón de los Herreros
Authors: Muro Miguel Ángel
Published: November 2017

El seductor castigado en la comedia de Bretón de los Herreros
Laberintos interartísticos o el "fatal destino literario" de un director de cine: "El proceso", de Manuel Gutiérrez Aragón
Authors: García-Abad García María Teresa
Published: November 2017

Laberintos interartísticos o el «fatal destino literario» de un director de cine: El proceso, de Manuel Gutiérrez Aragón
Estudiar el cine
Authors: González de Ávila Manuel
Published: November 2017

Estudiar el cine
La historia americana en el cine de Sydney Pollack
Authors: Hueso Montón Ángel Luis
Published: November 2017

La historia americana en el cine de Sydney Pollack
Cinefilias al margen de la sala de cine: huellas del cine y la televisión en la novela española del siglo XXI
Authors: Peña Ardid Carmen
Published: November 2017

Cinefilias al margen de la sala de cine: huellas del cine y la televisión en la novela española del siglo XXI
La deformación del lenguaje fílmico en "Las Truchas" de José Luis García Sánchez (1978)
Authors: Seoane Riveira José
Published: November 2017

La deformación del lenguaje fílmico en Las Truchas de José Luis García Sánchez (1978)
Urte bat baino gutxiagoko umeengan agertutako nerbio-sistema zentraleko tumoreak: berrikuspena Gurutzetako Unibertsitate Ospitalean eta literaturan
Authors: Ruiz de Gopegui Edurne , Bilbao Gaizka , Galbarriatu Lara , Catalán Gregorio , García-Ariza Miguel , Astigarraga Itziar , Zaldumbide Laura , Dolado Ainara , Pomposo Iñigo
Published: November 2017

Lan honen helburua Gurutzetako Unibertsitate Ospitalean urtebete baino gutxiagoko umeengan agertu diren nerbio-sistema zentraleko tumoreen kasuak eta haien gaineko literatura berrikustea izan da. Urtebete edo gutxiagoko umeengan 2001-2016 bitartean diagnostitatutako NSZko tumoreen kasuak ikertu dira. Haien diagnosi-adina, kokapena, tratamendu neurokirurgikoa, hidrozefaliaren agerpena, biziraupena eta gaixotasunaren segimendua berrikusi dira. Gurutzeta Unibertsitate Ospitaleko Onkologia-Hematologia-Pediatriako Unitatean 2001-2016 urteen artean artatutako NSZko tumorea izan zuten 14 urtetik beherako 158 pazienteen artean, urtebetetik beherako 16 tratatu ziren. Hamalau tumore supratentorialak izan ziren, bat infratentoriala eta beste bat ornomuin zerbikalean zegoen kokaturik. Kasu batean, diagnosia jaio aurrekoa izan zen. Anatomia patologikoari dagokionez, hamar gliomak izan ziren (bi gradu altukoak eta zortzi gradu baxukoak), hiru PNET (tumore neuroektodermiko primitiboa) infratentorialak, plexu koroideetako papiloma atipikoa bat, teratoide rabdoide atipiko bat, PNET supratentorial bat eta beste bat tumore neuroektodermiko melanozitikoa. Hamalau pazienterengan prozedura kirurgikoren bat gauzatu zen, eta hamabi kasutan kraniotomia eta neurri desberdinetako erauzketa izan ziren. Talde horretako bik prozedura kirurgiko bat baino gehiago behar izan zuten. Beste paziente birengan, kraniotomiaren ordez, biopsia estereotaktikoa baino ez zen egin orratz baten bitartez, diagnosia izanik helburu bakarra. Kirurgia ez zen mahaigaineratu gaixo biren kasuan, nerbio optikoko gliomen susmoa zegoelako. Gradu altuko tumoreetan, bost urteko biziraupena izan zuen kasu batean izan ezik, besteak ez ziren hain epe luzera heldu. Bi prozedura kirurgikoan bertan hil ziren. Gradu baxuko tumoreak zituzten hamarretik bederatzi bizirik daude oraindik, batez besteko 3,8 urteko biziraupenarekin. Bestea, 4,3 urte iraun eta gero, hil egin zen. Urtebete baino gutxiago duten umeen garuneko tumoreen ezaugarriak (portaera, pronostikoa…) eta nagusiagoenak nahiko desberdinak dira; talde haren ezaugarriak bereziak dira alegia. Gradu altuko tumoreetan, pronostikoak oso aurkakoa izaten jarraitzen du, hobetzeko ahaleginean ekin arren.
Thermal Decomposition of Hydroxylamine Nitrate Studied by Differential Scanning Calorimetry Analysis and Density Functional Theory Calculations
Authors: Liu Jianguo , An Zhentao , Zhang Qian , Wang Chaoyang
Published: November 2017

The thermal stability and kinetics of hydroxylamine nitrate (HAN) decomposition were studied by differential scanning calorimetry (DSC) and the thermal decomposition reaction mechanism was determined by density functional theory (DFT). With the help of parameter values from the non-isothermal DSC curves of HAN, the thermal decomposition activation energy and pre-exponential constant were obtained by the Kissinger and Ozawa methods. Then, the most probable mechanism function was calculated by the Šatava–Šesták method. Seven different paths for the thermal decomposition mechanism of HAN were formulated and DFT at the B3LYP/6-311++G(d,p) level was used to carry out the dynamics analysis. The calculated results show that the values of the activation energy calculated by the Kissinger and Ozawa methods are 67.892 and 70.412 kJ mol−1 respectively. The most probable mechanism function calculated by the Šatava–Šesták method is [Formula: see text]. The path being favoured energetically in the dynamics is in the order: Path6 > Path5 > Path4 > Path1 > Path2 > Path7 > Path3.
Enhanced Enzymatic Hydrolysis of Chitosan by Surfactant Addition
Authors: Rokhati Nur , Susanto Heru , Haryani Kristinah , Pramudono Bambang
Published: November 2017

Less attention has been paid for the effects of surfactant on the hydrolysis of chitosan. This paper presents the influence of the surfactant Tween 80 addition on the chitosan hydrolysis catalyzed by cellulase enzyme. The hydrolyzed chitosan was characterized by measuring its reducing sugar content, its chemistry by Fourier transforms infrared spectroscopy (FT-IR), its formation of aldehyde groups by ultraviolet - visible spectra (UV-Vis), and its crystallinity degree by X-ray diffraction (XRD). The results showed that Tween-80 could increase the hydrolysis rate and decrease the crystallinity of chitosan. The formation of reducing sugar increased by increasing reaction time up to 24 hours and then leveled off. A more significant effect of surfactant was observed when the hydrolysis was performed at a low surfactant concentration and a low substrate concentration. IR spectra showed that both raw and hydrolyzed chitosan have similar chemical structure.
Seroprevalence and risk factors of hepatitis B virus surface antigen among the workers in a garment factory
Authors: Rahman Mohammad Mizanur , Khatun Nasima , Habib Ahsan , Islam Md. Rafiqul , Islam Farhana
Published: November 2017

The purpose of this study is to find out the prevalence of seropositivity and risk factors associated with hepatitis B virus infection. A total of 2,737 readymade garment workers were initially screened after getting departmental as well as the individuals consent and simultaneously a questionnaire was filled up by the field research assistants to assess the risk factors. Initially 59 cases were found positive for hepatitis B virus surface antigen (HBsAg) by immunochromato-graphic test. Enzyme linked immunosorbant technique was then applied to the screened positive HBsAg individuals and four cases turned out as negative and therefore a total of 55  HBsAg positive cases were detected in this factory. Statistically significant risk factors associated with HBsAg positivity were jaundice, history of previous surgery and accident, needle stick injuries and unsafe injections. This study concludes that the seropositivity found garment workers is similar to the general population of Bangladesh.
Early versus late rehabilitation for stroke survivors: A prospective study
Authors: Khasru Moshiur Rahman , Salek A. K. M. , Moniruzzaman Mohammad , Marzen Tangila , Haseen Fariha , Siddiq Abu Bakar , Rizvi Abu Naser , Islam Md. Ariful , Hossain Zakir , Hossain Md. Shahdat , Anowar Nayeem , Hasan Md. , Ahmed Badrunnesa , Wilkinson David , Sakel Mohamed
Published: November 2017

The aim of this study was to examine the optimum time of rehabilitation initiation after stroke in terms of disabilities, mobility and fall risk assessment. Data were collected prospectively at seven tertiary level health care centers in Bangladesh during the 36 months period from 2013 to 2016. All respondents were divided into four groups based on the initiation of rehabilitation as: a) 0-24 hours, b) 25-72 hours, c) 4-7 days and d) 8-60 days. Results show that significant improvement on stroke recovery, disabilities reduction, improvement in mobility restriction and reduction of fall risks in all the four groups but more improvement was observed in 0-24 hour’s group during follow-up after 3 and 12 weeks. On multinomial logistic regression analysis, the independent factors shows the mobility restriction and fall risk were more in the younger patients, male gender, married, hemorrhagic lesion and bilateral stroke.
Unearthing the Spirit: The Archaeological Metaphor and the Uncanny Pathology of Romantic Ballet
Authors: Bing-Heidecker Liora
Published: November 2017

This article draws on Théophile Gautier's dance writings and Sigmund Freud's psychological tenets to explore major concepts of the romantic ballet and argue that the latter presents a hitherto ignored link between two apparently detached disciplines: archaeology and psychoanalysis. The thesis suggests that the romantic ballet assimilated, via Gautier, the highly popular archaeological metaphor of the mid nineteenth century. Its resulting aesthetic therefore bears the distinct marks of the uncanny, a psychoanalytical notion formulated later, yet stimulated by the same archaeological inspiration. Consequently I contend that the romantic ballet anticipated and materialized some current critical notions such as liminality, ambiguity and hauntology, deriving from Freud's theories. Historicizing the ballerina as a personification of ballet's uncanny pathology offers a contemporary perspective on the romantic theatrical dance and illuminates its relevance to post modernist culture.
‘Degenerate Dance’: The Case of Mary Wigman
Authors: Kew Carole
Published: November 2017

Mary Wigman (1886–1973) remained in Germany during the period of the Third Reich. Based on an article published in 1940 entitled Entarteter Tanz (Degenerate Dance), this essay discusses why the dance of Mary Wigman and, more broadly, why Weimar dance was labelled ‘degenerate’ by the National Socialist regime. The argument is framed with reference to an article written by Mary Wigman about her school which was published a few months later in the same prominent dance journal, Der Tanz.
Serge Lifar and the Question of Collaboration with the German Authorities under the Occupation of Paris (1940–1949)
Authors: Franko Mark
Published: November 2017

This article examines the political and artistic activities of dancer and choreographer Serge Lifar at the Paris Opéra during and immediately after the occupation of Paris. Although Lifar was cleared of charges of collaborationism with the German authorities after the war, the question of collaborationism has arisen again in light of the rehabilitation of his aesthetic by the Paris Opéra and other dance companies. Using archival materials usually ignored by dance scholars, this article examines Lifar's political activities, his political convictions, and his political ambitions. His theory of ballet as set forth in La Danse: les grands courants de la danse académique (1938) and two of his successful ballets of this period – Joan de Zarissa (1942) and Suite en blanc (1943) – are discussed in light of his politics.
The Subcellular Distribution of Alpha-Tocopherol in the Adult Primate Brain and Its Relationship with Membrane Arachidonic Acid and Its Oxidation Products
Authors: Mohn Emily , Kuchan Matthew , Erdman John , Neuringer Martha , Matthan Nirupa , Chen Chung-Yen , Johnson Elizabeth
Published: November 2017

The relationship between α-tocopherol, a known antioxidant, and polyunsaturated fatty acid (PUFA) oxidation, has not been directly investigated in the primate brain. This study characterized the membrane distribution of α-tocopherol in brain regions and investigated the association between membrane α-tocopherol and PUFA content, as well as brain PUFA oxidation products. Nuclear, myelin, mitochondrial, and neuronal membranes were isolated using a density gradient from the prefrontal cortex (PFC), cerebellum (CER), striatum (ST), and hippocampus (HC) of adult rhesus monkeys (n = 9), fed a stock diet containing vitamin E (α-, γ-tocopherol intake: ~0.7 µmol/kg body weight/day, ~5 µmol/kg body weight/day, respectively). α-tocopherol, PUFAs, and PUFA oxidation products were measured using high performance liquid chromatography (HPLC), gas chromatography (GC) and liquid chromatography-gas chromatography/mass spectrometry (LC-GC/MS) respectively. α-Tocopherol (ng/mg protein) was highest in nuclear membranes (p < 0.05) for all regions except HC. In PFC and ST, arachidonic acid (AA, µg/mg protein) had a similar membrane distribution to α-tocopherol. Total α-tocopherol concentrations were inversely associated with AA oxidation products (isoprostanes) (p < 0.05), but not docosahexaenoic acid oxidation products (neuroprostanes). This study reports novel data on α-tocopherol accumulation in primate brain regions and membranes and provides evidence that α-tocopherol and AA are similarly distributed in PFC and ST membranes, which may reflect a protective effect of α-tocopherol against AA oxidation.
Dynamic Shear Degradation of Geosynthetic–Soil Interface in Waste Landfill Sites
Authors: Kwak Changwon , Park Junboum , Jang Dongin , Park Innjoon
Published: November 2017

Geosynthetics and soil particles inevitably come into contact, resulting in a geosynthetic–soil interface. The discontinuity of the materials at the interface causes an intricate shear response, especially under dynamic loads. In the present study, the effects of chemical aggressors of the leachate from a waste landfill site on the cyclic shear behaviors of a geosynthetic–soil interface were investigated. The Multi-Purpose Interface Apparatus (M-PIA) that can simulate cyclic simple shear conditions was utilized, and 72 sets of cyclic simple shear tests were conducted. The Disturbed State Concept (DSC) was employed to quantitatively estimate the shear stress degradation. As a result, new disturbance functions and parameters that represent the characteristics of the dynamic shear degradation at the interface were evaluated. Additionally, a numerical back-prediction was performed to verify the accuracy and applicability of the DSC parameters. Numerical interpolation procedures were suggested and enabled to reproduce the degradation successfully. Consequently, a general methodology was established to estimate the cyclic shear stress degradation of the geosynthetic–soil interface in consideration of chemical effects.
Evaluation of the Cooling and Pavement Performance of Basic Oxygen Furnace Slag Used in Asphalt Mixture
Authors: Huang Long-Sheng
Published: November 2017

Basic oxygen furnace slag (BOF) is widely used in road construction, but there is a lack of characteristics in different asphalt mixtures. This study investigates the properties of hot-mixed asphalt (HMA), containing stone mastic asphalt (SMA), porous asphalt (PA), and dense-graded BOF as a partial substitution for natural aggregates. The purpose of this study is to evaluate various BOF slag contents in the asphalt mixtures that would affect the cooling behavior after compaction. Asphalt mixture specimens contained 0%, 20%, 40% and 60% BOF slag, respectively, as coarse aggregate. Test results showed that BOF slag has a lipophilic property, so that it can be adsorbed by asphalt cement, thereby reducing the cost of asphalt. The stability value of all the asphalt mixtures increases with the proportion of BOF slag replacement. In addition, the voids in the mineral aggregate (VMA) value variable exhibited significant differences among asphalt mixtures, and could determine the deviation of the cooling trend of asphalt mixtures. Furthermore, it was found that the cooling procedure of the BOF slag used in dense-graded asphalt mixture takes about 100 min, and that the temperature tends to be moderate; however, it took about 120 min of cooling the SMA and PA mixture with BOF slag. In addition, the distribution of voids of the dense asphalt mixture was not uniform. This would result in various locations of inconsistent thermal energy temperature on asphalt mixtures.
Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer
Authors: Wang Xuemin , Xie Jianling , Proud Christopher
Published: November 2017

Eukaryotic elongation factor 2 kinase (eEF2K) is a highly unusual protein kinase that negatively regulates the elongation step of protein synthesis. This step uses the vast majority of the large amount of energy and amino acids required for protein synthesis. eEF2K activity is controlled by an array of regulatory inputs, including inhibition by signalling through mammalian target of rapamycin complex 1 (mTORC1). eEF2K is activated under conditions of stress, such as energy depletion or nutrient deprivation, which can arise in poorly-vascularised tumours. In many such stress conditions, eEF2K exerts cytoprotective effects. A growing body of data indicates eEF2K aids the growth of solid tumours in vivo. Since eEF2K is not essential (in mice) under ‘normal’ conditions, eEF2K may be a useful target in the treatment of solid tumours. However, some reports suggest that eEF2K may actually impair tumorigenesis in some situations. Such a dual role of eEF2K in cancer would be analogous to the situation for other pathways involved in cell metabolism, such as autophagy and mTORC1. Further studies are needed to define the role of eEF2K in different tumour types and at differing stages in tumorigenesis, and to assess its utility as a therapeutic target in oncology.
Ene-yne Cross-Metathesis for the Preparation of 2,3-Diaryl-1,3-dienes
Authors: Abderrezak Meriem , Kabouche Zahia , Bruneau Christian , Fischmeister Cédric
Published: November 2017

Ene-yne cross-metathesis from alkynes and ethylene is a useful method to produce substituted conjugated butadiene derivatives. If this method has been used with aliphatic alkynes, it has however never been used starting from diarylacetylenes as internal alkynes. We show that the ene-yne cross-metathesis catalyzed by the second generation Hoveyda ruthenium catalyst provides the 2,3-diarylbuta-1,3-dienes under 3 atm of ethylene at 100 °C. The scope and limitations of the reaction have been evaluated starting from unsymmetrical functionalized diarylacetylene derivatives hence leading to unsymmetrical 2,3-diarylbuta-1,3-dienes in a straightforward and environmentally acceptable manner.
Venture from the Interior—Herpesvirus pUL31 Escorts Capsids from Nucleoplasmic Replication Compartments to Sites of Primary Envelopment at the Inner Nuclear Membrane
Authors: Bailer Susanne
Published: November 2017

Herpesviral capsid assembly is initiated in the nucleoplasm of the infected cell. Size constraints require that newly formed viral nucleocapsids leave the nucleus by an evolutionarily conserved vescular transport mechanism called nuclear egress. Mature capsids released from the nucleoplasm are engaged in a membrane-mediated budding process, composed of primary envelopment at the inner nuclear membrane and de-envelopment at the outer nuclear membrane. Once in the cytoplasm, the capsids receive their secondary envelope for maturation into infectious virions. Two viral proteins conserved throughout the herpesvirus family, the integral membrane protein pUL34 and the phosphoprotein pUL31, form the nuclear egress complex required for capsid transport from the infected nucleus to the cytoplasm. Formation of the nuclear egress complex results in budding of membrane vesicles revealing its function as minimal virus-encoded membrane budding and scission machinery. The recent structural analysis unraveled details of the heterodimeric nuclear egress complex and the hexagonal coat it forms at the inside of budding vesicles to drive primary envelopment. With this review, I would like to present the capsid-escort-model where pUL31 associates with capsids in nucleoplasmic replication compartments for escort to sites of primary envelopment thereby coupling capsid maturation and nuclear egress.
In-Situ Growth and Characterization of Indium Tin Oxide Nanocrystal Rods
Authors: Shen Yan , Lou Youxin , Wang Zhihao , Xu Xiangang
Published: November 2017

Indium tin oxide (ITO) nanocrystal rods were synthesized in-situ by a vapor-liquid-solid (VLS) method and electron beam evaporation technique. When the electron-beam gun bombarded indium oxide (In2O3) and tin oxide (SnO2) mixed sources, indium and tin droplets appeared and acted as catalysts. The nanocrystal rods were in-situ grown on the basis of the metal catalyst point. The nanorods have a single crystal structure. Its structure was confirmed by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The surface morphology was analyzed by scanning electron microscopy (SEM). During the evaporation, a chemical process was happened and an In2O3 and SnO2 solid solution was formed. The percentage of doped tin oxide was calculated by Vegard’s law to be 3.18%, which was in agreement with the mixture ratio of the experimental data. The single crystal rod had good semiconductor switch property and its threshold voltage of single rod was approximately 2.5 V which can be used as a micro switch device. The transmission rate of crystalline nanorods ITO film was over 90% in visible band and it was up to 95% in the blue green band as a result of the oxygen vacancy recombination luminescence.
Bayesian Inference of Ecological Interactions from Spatial Data
Authors: Stephens Christopher , Sánchez-Cordero Victor , González Salazar Constantino
Published: November 2017

The characterization and quantification of ecological interactions and the construction of species’ distributions and their associated ecological niches are of fundamental theoretical and practical importance. In this paper, we discuss a Bayesian inference framework, which, using spatial data, offers a general formalism within which ecological interactions may be characterized and quantified. Interactions are identified through deviations of the spatial distribution of co-occurrences of spatial variables relative to a benchmark for the non-interacting system and based on a statistical ensemble of spatial cells. The formalism allows for the integration of both biotic and abiotic factors of arbitrary resolution. We concentrate on the conceptual and mathematical underpinnings of the formalism, showing how, using the naive Bayes approximation, it can be used to not only compare and contrast the relative contribution from each variable, but also to construct species’ distributions and ecological niches based on an arbitrary variable type. We also show how non-linear interactions between distinct niche variables can be identified and the degree of confounding between variables accounted for.
Group Sparsity and Graph Regularized Semi-Nonnegative Matrix Factorization with Discriminability for Data Representation
Authors: Luo Peng , Peng Jinye
Published: November 2017

Semi-Nonnegative Matrix Factorization (Semi-NMF), as a variant of NMF, inherits the merit of parts-based representation of NMF and possesses the ability to process mixed sign data, which has attracted extensive attention. However, standard Semi-NMF still suffers from the following limitations. First of all, Semi-NMF fits data in a Euclidean space, which ignores the geometrical structure in the data. What’s more, Semi-NMF does not incorporate the discriminative information in the learned subspace. Last but not least, the learned basis in Semi-NMF is unnecessarily part based because there are no explicit constraints to ensure that the representation is part based. To settle these issues, in this paper, we propose a novel Semi-NMF algorithm, called Group sparsity and Graph regularized Semi-Nonnegative Matrix Factorization with Discriminability (GGSemi-NMFD) to overcome the aforementioned problems. GGSemi-NMFD adds the graph regularization term in Semi-NMF, which can well preserve the local geometrical information of the data space. To obtain the discriminative information, approximation orthogonal constraints are added in the learned subspace. In addition, ℓ 21 norm constraints are adopted for the basis matrix, which can encourage the basis matrix to be row sparse. Experimental results in six datasets demonstrate the effectiveness of the proposed algorithms.
Two Stage Analysis of Successful Change Implementation of Knowledge Management Strategies in Energy Companies from Romania
Authors: Ceptureanu Eduard , Ceptureanu Sebastian , Popescu Doina , Vlad Liviu
Published: November 2017

The purpose of this paper is to emphasize the effects of knowledge management strategies toward organizational change in Romanian companies from the energy sector. This study explored a new vision to implement these types of organizational changes successfully in companies from the Romanian sector of energy and obtain their early benefits by using knowledge management strategies and also reveal the mediating effect of organizational learning and readiness for change. The results highlighted how energy companies can implement an Enterprise Resource Planning (ERP)-based change effectively through KM strategies. The results are equally valuable for all Romanian organizations that are currently changing their working environment.
The Environmental Burdens of Lead-Acid Batteries in China: Insights from an Integrated Material Flow Analysis and Life Cycle Assessment of Lead
Authors: Chen Sha , Lian Zhenyue , Li Sumei , Kim Junbeum , Li Yipei , Cao Lei , Liu Zunwen
Published: November 2017

Lead-acid batteries (LABs), a widely used energy storage equipment in cars and electric vehicles, are becoming serious problems due to their high environmental impact. In this study, an integrated method, combining material flow analysis with life cycle assessment, was developed to analyze the environmental emissions and burdens of lead in LABs. The environmental burdens from other materials in LABs were not included. The results indicated that the amount of primary lead used in LABs accounted for 77% of the total lead production in 2014 in China. The amount of discharged lead into the environment was 8.54 × 105 tonnes, which was mainly from raw material extraction (57.2%). The largest environmental burden was from the raw materials extraction and processing, which accounted for 81.7% of the total environmental burdens. The environmental burdens of the environmental toxicity potential, human toxicity potential-cancer, human toxicity potential-non-cancer, water footprint and land use accounted for more than 90% at this stage. Moreover, the environmental burdens from primary lead was much more serious than regenerated lead. On the basis of the results, main practical measures and policies were proposed to reduce the lead emissions and environmental burdens of LABs in China, namely establishing an effective LABs recycling system, enlarging the market share of the legal regenerated lead, regulating the production of regenerated lead, and avoiding the long-distance transportation of the waste LABs.
A Strategy for Identifying Quantitative Trait Genes Using Gene Expression Analysis and Causal Analysis
Authors: Ishikawa Akira
Published: November 2017

Large numbers of quantitative trait loci (QTL) affecting complex diseases and other quantitative traits have been reported in humans and model animals. However, the genetic architecture of these traits remains elusive due to the difficulty in identifying causal quantitative trait genes (QTGs) for common QTL with relatively small phenotypic effects. A traditional strategy based on techniques such as positional cloning does not always enable identification of a single candidate gene for a QTL of interest because it is difficult to narrow down a target genomic interval of the QTL to a very small interval harboring only one gene. A combination of gene expression analysis and statistical causal analysis can greatly reduce the number of candidate genes. This integrated approach provides causal evidence that one of the candidate genes is a putative QTG for the QTL. Using this approach, I have recently succeeded in identifying a single putative QTG for resistance to obesity in mice. Here, I outline the integration approach and discuss its usefulness using my studies as an example.
Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage
Authors: Velalopoulou Anastasia , Chatterjee Shampa , Pietrofesa Ralph , Koziol-White Cynthia , Panettieri Reynold , Lin Liyong , Tuttle Stephen , Berman Abigail , Koumenis Constantinos , Christofidou-Solomidou Melpo
Published: November 2017

Radiation therapy for the treatment of thoracic malignancies has improved significantly by directing of the proton beam in higher doses on the targeted tumor while normal tissues around the tumor receive much lower doses. Nevertheless, exposure of normal tissues to protons is known to pose a substantial risk in long-term survivors, as confirmed by our work in space-relevant exposures of murine lungs to proton radiation. Thus, radioprotective strategies are being sought. We established that LGM2605 is a potent protector from radiation-induced lung toxicity and aimed in the current study to extend the initial findings of space-relevant, proton radiation-associated late lung damage in mice by looking at acute changes in human lung. We used an ex vivo model of organ culture where tissue slices of donor living human lung were kept in culture and exposed to proton radiation. We exposed donor human lung precision-cut lung sections (huPCLS), pretreated with LGM2605, to 4 Gy proton radiation and evaluated them 30 min and 24 h later for gene expression changes relevant to inflammation, oxidative stress, and cell cycle arrest, and determined radiation-induced senescence, inflammation, and oxidative tissue damage. We identified an LGM2605-mediated reduction of proton radiation-induced cellular senescence and associated cell cycle changes, an associated proinflammatory phenotype, and associated oxidative tissue damage. This is a first report on the effects of proton radiation and of the radioprotective properties of LGM2605 on human lung.
The Genetic Basis of Psoriasis
Authors: Capon Francesca
Published: November 2017

Psoriasis is widely regarded as a multifactorial condition which is caused by the interaction between inherited susceptibility alleles and environmental triggers. In the last decade, technological advances have enabled substantial progress in the understanding of disease genetics. Genome-wide association studies have identified more than 60 disease susceptibility regions, highlighting the pathogenic involvement of genes related to Th17 cell activation. This pathway has now been targeted by a new generation of biologics that have shown great efficacy in clinical trials. At the same time, the study of rare variants of psoriasis has identified interleukin (IL)-36 cytokines as important amplifiers of Th17 signaling and promising targets for therapeutic intervention. Here, we review these exciting discoveries, which highlight the translational potential of genetic studies.
Ecology and Evolution in the RNA World Dynamics and Stability of Prebiotic Replicator Systems
Authors: Szilágyi András , Zachar István , Scheuring István , Kun Ádám , Könnyű Balázs , Czárán Tamás
Published: November 2017

As of today, the most credible scientific paradigm pertaining to the origin of life on Earth is undoubtedly the RNA World scenario. It is built on the assumption that catalytically active replicators (most probably RNA-like macromolecules) may have been responsible for booting up life almost four billion years ago. The many different incarnations of nucleotide sequence (string) replicator models proposed recently are all attempts to explain on this basis how the genetic information transfer and the functional diversity of prebiotic replicator systems may have emerged, persisted and evolved into the first living cell. We have postulated three necessary conditions for an RNA World model system to be a dynamically feasible representation of prebiotic chemical evolution: (1) it must maintain and transfer a sufficient diversity of information reliably and indefinitely, (2) it must be ecologically stable and (3) it must be evolutionarily stable. In this review, we discuss the best-known prebiotic scenarios and the corresponding models of string-replicator dynamics and assess them against these criteria. We suggest that the most popular of prebiotic replicator systems, the hypercycle, is probably the worst performer in almost all of these respects, whereas a few other model concepts (parabolic replicator, open chaotic flows, stochastic corrector, metabolically coupled replicator system) are promising candidates for development into coherent models that may become experimentally accessible in the future.
Effect of Clinically Relevant CAD/CAM Zirconia Polishing on Gingival Fibroblast Proliferation and Focal Adhesions
Authors: Fischer Nicholas , Wong Jeffrey , Baruth Andrew , Cerutis D.
Published: November 2017

Mucosal seal formation around dental abutments is critical to the successful integration of dental implants into the human oral cavity. No information exists for how clinically relevant polishing procedures for computer-aided design and computer-aided manufactured (CAD/CAM) zirconia abutments affects cellular responses important to mucosal seal formation. CAD/CAM zirconia was divided into four groups for clinically relevant polishing utilizing commercial polishing heads: control, coarse, coarse plus medium, and coarse plus medium plus fine. Surfaces were analyzed with scanning electron microscopy (SEM), atomic force microscopy (AFM), and optical profilometry (OP). Subsequently, human gingival fibroblasts (HGFs) were seeded onto the zirconia surfaces. Proliferation was measured via a quantitative SEM technique and focal adhesion kinase (FAK) phosphorylation status was measured by an enzyme-linked immunosorbent assay (ELISA). Results showed an increase in proliferation on all polished surfaces as compared to the control. Phosphorylation of FAK at tyrosine 397 (Y397) was up-modulated on the control surfaces. The associated cell adaptation is discussed. In all cases, FAK phosphorylation was greater at 24 h than 48 h. These results suggest that clinicians should be mindful of the effects of abutment polishing methodology, as this may have an impact on early mucosal seal formation.
Magnetic Adsorbents for the Recovery of Precious Metals from Leach Solutions and Wastewater
Authors: Aghaei Elham , Alorro Richard , Encila Ashly , Yoo Kyoungkeun
Published: November 2017

Precious metals which include the platinum group, gold, and silver, play indispensable roles in high technology industries of the modern world due to their outstanding physical and chemical properties. As a result of diminishing availability of mineral sources, increasing demand, and environmental concerns, the recovery of precious metals from both leaching and industrial waste solutions is becoming a very important technology. Magnetic solid phase extraction (MSPE) is a technique that has received substantial consideration in the separation and recovery of precious metals because of the many advantages it offers compared to conventional methods. This technique is based on the extraction of different analytes from solutions using solid adsorbents with magnetic properties. This review focuses on different types of magnetic adsorbents, the main procedures used for synthesis, characterization and their application in precious metals recovery based on recently published literatures.
Microstructure of Multi-Pass Friction-Stir-Processed Al-Zn-Mg-Cu Alloys Reinforced by Nano-Sized TiB2 Particles and the Effect of T6 Heat Treatment
Authors: Ju Xiaofei , Zhang Fengguo , Chen Zhe , Ji Gang , Wang Mingliang , Wu Yi , Zhong Shengyi , Wang Haowei
Published: November 2017

In this work, a fine-grained structure with a uniform distribution of TiB2 particles and precipitates was achieved in TiB2 particle-reinforced (PR) Al-Zn-Mg-Cu alloys by friction stir processing (FSP). The effects of multi-pass FSP on the microstructure, and TiB2 particle distribution, as well as the microstructural evolution in the following T6 treatment, were investigated by X-ray diffraction, scanning electron microscopy and associated electron backscattered diffraction. The results showed that the distribution of TiB2 particles and alloy precipitates was further improved with an increase in the FSP passes. Moreover, compared with alloy segregation in the as-cast PR alloys during T6 treatment, a complete solution of the precipitates was achieved in the FSP-treated PR alloys. The fine-grained structure of the FSP-treated PR alloys was thermally stable without any abnormal growth at the high temperature of T6 treatment due to the pinning effect of dispersed TiB2 particles. The strength and ductility of the PR alloys were simultaneously improved by the combination of FSP and T6 treatment.
Drug-Target Interaction Prediction through Label Propagation with Linear Neighborhood Information
Authors: Zhang Wen , Chen Yanlin , Li Dingfang
Published: November 2017

Interactions between drugs and target proteins provide important information for the drug discovery. Currently, experiments identified only a small number of drug-target interactions. Therefore, the development of computational methods for drug-target interaction prediction is an urgent task of theoretical interest and practical significance. In this paper, we propose a label propagation method with linear neighborhood information (LPLNI) for predicting unobserved drug-target interactions. Firstly, we calculate drug-drug linear neighborhood similarity in the feature spaces, by considering how to reconstruct data points from neighbors. Then, we take similarities as the manifold of drugs, and assume the manifold unchanged in the interaction space. At last, we predict unobserved interactions between known drugs and targets by using drug-drug linear neighborhood similarity and known drug-target interactions. The experiments show that LPLNI can utilize only known drug-target interactions to make high-accuracy predictions on four benchmark datasets. Furthermore, we consider incorporating chemical structures into LPLNI models. Experimental results demonstrate that the model with integrated information (LPLNI-II) can produce improved performances, better than other state-of-the-art methods. The known drug-target interactions are an important information source for computational predictions. The usefulness of the proposed method is demonstrated by cross validation and the case study.
Live Fluorescent Staining Platform for Drug-Screening and Mechanism-Analysis in Zebrafish for Bone Mineralization
Authors: Chen Jung-Ren , Lai Yu-Heng , Tsai Jhih-Jie , Hsiao Chung-Der
Published: November 2017

Currently, drug screening relies on cell-based experiments or on animal models to confirm biological effects. The mammalian system is considered too time-consuming, expensive and complex to perform high-throughput drug screening. There is a gap between in vitro cell-based models and the in vivo mammalian models. The zebrafish is an ideal model that could link preclinical toxicity screening with the drug development pipeline. Taking advantage of a highly conservative genomic, rapid development, large number of offspring, low cost and easy manipulation, zebrafish has been considered an excellent animal model for disease-based drug screening. In this study, zebrafish embryos were incubated with small molecular compounds that potentially affected bone mineralization in microplates. Two compounds of alendronate and dorsomorphin were used as positive and negative controls, respectively. The level of osteogenic mineralization was measured and quantified by using ImageJ software with fluorescent calcein-staining images. Among twenty-four tested compounds from the kinase inhibitor library, we identified two compounds, pentamidine and BML-267, which showed increased embryonic mineralization; while six compounds, RWJ-60475, levamisole HCL, tetramisole HCL, fenvalerate, NSC-663284, and BML-267ester, were inhibitory to bone mineralization. In addition, real time quantitative PCR (RT-qPCR) was performed to evaluate the biological pathways involved in bone metabolism at the molecular level. We confirmed that alendronate enhanced the level of bone mineralization by inhibiting osteoclast-related genes. In summary, our research established a simple method to screen potential bone metabolic drugs and to perform mechanism analysis for bone mineralization in vivo.