bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative study between ureter first approach and conventional open Anderson-Hynes pyeloplasty in paediatric patients: A prospective randomised study
Authors: Fathi Basem A. , Elgammal Ahmed A. , Abouelgreed Tamer A. , Ghoneimy Osama M. , Abdrabuh Abdrabuh M. , Hindawy Mohamed A. , Aboelsaad Ahmed Y. , Deif Hazem , Mahmoud Alaa
Published: March 2023

Background: Uretero-pelvic junction obstruction is the most common form of congenital anomaly of the kidney and urinary tract with an incidence of about 1/1.000-1.500 of births and the aetiology and pathogenesis of this anomaly are still unclear until now.

Methods: This is a prospective randomized comparative study conducted from March 2022 to December 2022. Thirty children with uretero-pelvic junction obstruction were included and randomly divided into two groups according to a 1:1 ratio (computer-generated randomization, single blind). Fifteen cases (12 males and 3 female) were subjected to ureter first approach pyeloplasty, and another fifteen (9 males and 6 female) were subjected to conventional Anderson Hynes pyeloplasty.
Results: The mean age of all patients was 6.7 ± 5.4 years in ureter first approach group and 5.1 ± 4.3 years in conventional Anderson-Hynes pyeloplasty group. There were no significant differences between the two groups regarding age, gender, presentation, side, preoperative renogram and post-operative renogram. Also, there were no significant differences between the two groups regarding operative time (in first group 110.3 ± 12.4 and in the second group 111.2 ± 12.0 with p < 0.836), pre and post-operative complication rate. Two cases of urinary tract infections in the first group, one of them having fever, and four cases in the second group, two of them having fever (p < 0.651); four cases of loin pain in the first group and one case in the second group (p < 0.330); one case in the first group having pro- longed leakage of urine for 7 days in post-operative period (p < 0.309). However GFR and t 1⁄2 improved significantly after operation in both groups (p < 0.001).
Conclusions: Ureter first approach is a simple and effective procedure in children with good short term outcomes and could be done safely especially for beginners and less expert surgeons. Finally, it can overcome the problem of long ureteric stricture that may be found intraoperatively because you can shift easily to a flap procedure and complete a tension free anastomosis.
Survival and swimming performance of a small-sized Cypriniformes (Telestes muticellus) tagged with passive integrated transponders
Authors: Schiavon Alfredo , Comoglio Claudio , Candiotto Alessandro , Hölker Franz , Ashraf Muhammad Usama , Nyqvist Daniel
Published: March 2023

Italian riffle dace (Telestes muticellus, Bonaparte 1837) is a small-bodied Leuciscidae native to the Italian Peninsula, of which little is known about the ecology and individual movements in nature. Passive Integrated Transponder (PIT) telemetry is used to track fish movements and behaviour. The basic assumption is that the PIT-tagged organism's performances do not differ considerably from their natural behaviour. Here we present the first evaluation of potential tagging effects in the genus Telestes. The survival rate and tag retention were compared between two different tag implantation methods – injector gun and scalpel incision - and pit-tagging effects on swimming performance were evaluated. Five weeks after tagging, Italian riffle dace demonstrated high survival rates in all treatments: 94.8% for fish tagged with injector gun (n=58), 100% for scalpel incision method (n=58), and 98.3% for controls (n=58). The tag retention was 96.6% for gun treatment and 100% for scalpel treatment. Prolonged swimming performance, tested 22-23 days after tagging, showed a reduction in endurance (time-to-fatigue) for scalpel treatment (n=22) compared to the control group (n=21), while no difference in maximum swimming velocity was observed. We conclude that PIT tagging is a suitable technique for Italian riffle dace, showing high survival and PIT retention and no effect on maximum swimming speed. Significantly lower prolonged swimming performance, although likely less ecologically important, shows that tagging is not without costs. Potential biases need to be evaluated on a study-by-study basis, and future studies should explore behavioural tagging effects in nature.
Development and Psychometric Properties of an Extended Theory of Planned Behavior Questionnaire for Childbearing Intentions and Behaviors in Iran
Authors: Moeini Babak , Erfani Amir , Barati Majid , Doosti-Irani Amin , Hosseini Hatam , Soheylizad Mokhtar
Published: March 2023

Background: Childbearing is the most important determinant of population fluctuations, and its study is more important than other population phenomena. Owing to the lack of a valid questionnaire based on the extended theory of planned behavior, this mixed-method study was conducted to determine the validity and reliability of a questionnaire designed to examine related belief-based factors on the intention to bear children in Iranian society.Methods: This study was conducted in two phases in Hamadan city, western Iran, in 2021. Phase 1 consisted of an extensive literature review and a qualitative study using a directed content analysis approach to generate an item pool. Psychometrics were measured in phase 2, including content, face, and construct validity. Reliability was assessed based on internal consistency and stability. The collected data were analyzed using IBM SPSS and AMOS ver. 24.0.Results: Mean content validity ratio and content validity index were 0.7 and 0.85, respectively. Exploratory factor analysis of the 32 items identified an eight-factor solution. These factors jointly accounted for 79.1% of the observed variance in the outcome variables. Confirmatory factor analysis indicated a good fit for the data. The internal consistency based on Cronbach’s α was 0.85 (0.71–0.93). In addition, stability was confirmed using the test-retest method and intraclass correlation coefficient (0.74–0.94).Conclusion: The designed questionnaire is a valid and reliable instrument for evaluating related belief-based factors on the intention and behavior of childbearing among married men and women in Iran.
Association of Coffee or Green Tea with Ferritin or Hemoglobin in Premenopausal Women
Authors: Lee Dagyeong , Jung Wonyoung , Shin Dong Wook
Published: March 2023

Background: This study aimed to examine the association between coffee or green tea consumption and ferritin or hemoglobin levels in premenopausal women.Methods: We used the fifth Korea National Health and Nutrition Examination Survey (2010–2012), and a total of 4,322 individuals were surveyed. In women of reproductive age, average ferritin and hemoglobin levels were calculated according to coffee or green tea consumption. Covariates included in the analysis were demographic variables, such as age, body mass index, education, drinking, smoking, history of hypertension, history of diabetes diagnosis, physical activity, total energy intake, and daily iron intake.Results: In 4,322 participants, the average hemoglobin level was 12.90±0.02 g/dL, and the average level of ferritin was 31.95±0.67 ng/mL. As a result of testing, correlation between ferritin and coffee intake and difference in ferritin levels according to coffee consumption was significant (P<0.05). In this study, a post hoc test indicated that ferritin level significantly differed between one and two cups, two and three cups, and three and one cup groups (overall P<0.001). Additionally, there was a negative correlation between ferritin level and coffee intake; ferritin level decreased by 2.09 ng/mL with a one-cup increase in daily coffee consumption.Conclusion: In premenopausal women, coffee intake is associated with low serum ferritin levels. Our results indicate that drinking >2 cups of coffee significantly affect ferritin levels in Korean premenopausal women.
Adenomyoepithelial adenosis mimicking phylloides: A diagnostic dilemma
Authors: Singh Jyoty , Singhai Atin , Babu Suresh , Singh Kulranjan , Mishra Anand
Published: March 2023

Benign proliferative breast diseases are well recognized in young females. Benign biphasic proliferation of epithelial and myoepithelial cells has been observed, among which adeno-myoepithelial adenosis is one of the rare morphologies published in the literature with the tendency to recur and poses a risk for low-grade malignant transformation. Here, we report a case of a young female who had a history of recurrent breast lump mimicking phyllodes tumor and eventually diagnosed as adeno-myoepithelial adenosis on histopathological examination.
Accuracy Evaluation of Pediatric Appendicitis Scoring (PAS) Method in Differentiating Nonspecific Abdominal Pain from Appendicitis
Authors: Raeisi Roya , Azizi Mona , Amiri Jalaleddin , Ghorbanpour Manouchehr , Esna-Ashari Farzaneh
Published: March 2023

Background:

This study aimed at evaluating the accuracy of the pediatric appendicitis scoring method in differentiating nonspecific abdominal pain (NSAP) from appendicitis.

Methods:

This cross-sectional study was conducted on 391 children who were hospitalized in the emergency ward due to acute abdominal pain suspected of appendicitis. Pediatric Appendicitis Score (PAS), C-reactive protein (CRP), and appendicitis pathology results of patients undergoing surgery were recorded.

Results:

The results showed that the no significant difference was found among patients in the three experimental groups (appendicitis, specific abdominal pain except appendicitis, and NSAP) with respect to temperature (p = 0.212), but the other variables were significantly different. Findings showed that high CRP frequency, pain migration to right lower quadrant (RLQ), tenderness in right iliac fossa (RIF), anorexia, leukocytosis, high neutrophil, and mean tenderness in RLQ in the appendicitis group were higher than those in the other two groups (p = 0.001). The PAS questionnaire can also be used as a reliable questionnaire with appropriate sensitivity (0.929) and specificity (0.993), and this questionnaire along with detailed clinical examinations could reduce the rate of negative appendectomy to less than 1%.

Conclusions:

This study showed high accuracy of PAS in diagnosing children with appendicitis and differentiating appendicitis from cases of NSAP and specific abdominal pain other than appendicitis. The PAS system could also significantly reduce cases of negative appendicitis. Although high CRP had an excellent ability to diagnose appendicitis, its accuracy was lower than PAS.
Prenatal Diagnosis of Euploid Increased Nuchal Translucency on Fetal Ultrasound (II)
Authors: Chen Chih-Ping
Published: March 2023

Prenatal diagnosis of euploid increased nuchal translucency (NT) remains a challenge to obstetricians and genetic counselors, although increased euploid NT at prenatal diagnosis can be associated with a favorable outcome. Prenatal diagnosis of euploid increased NT should include a differential diagnosis of pathogenetic copy number variants and RASopathy disorders (RDs) including Noonan syndrome. Therefore, chromosomal microarray analysis, whole-exome sequencing, RASopathy-disorder testing, and protein-tyrosine phosphatase nonreceptor type 11 gene testing may be necessary under such a circumstance. In this report, a comprehensive review of RDs with its prenatal ultrasound findings and genotype-phenotype correlations is presented.
Clinical and baseline computed tomography features of patients infected with the B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2
Authors: Mao Haixia , Xu Jixiong , Gong Shengbing , Chen Hongwei , Fang Xiangming
Published: March 2023

PURPOSE:

The purpose of this study was to investigate the clinical and baseline computed tomography (CT) features and their correlation in patients infected with the B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

MATERIALS AND METHODS:

Clinical and chest baseline CT data of patients infected with the Delta variant of SARS-CoV-2 from July to August 2021 were collected. First, the correlation between the clinical data and baseline CT results was analyzed according to CT positivity or negativity. Then, subgroup analysis was performed between different age distributions and clinical characteristics. Next, the CT characteristics and clinical data of all baseline CT-positive patients were collected, and the correlations between CT characteristics and age, vaccination status, and chronic disease were analyzed. Lesions in patients with baseline CT positivity were evaluated by semi-quantitative scoring to analyze the correlations between the semi-quantitative scores and vaccination status and age distribution.

RESULTS:

A total of 221 nucleic acid-positive patients with the SARS-CoV-2 Delta variant were included, of whom 107 patients were baseline CT positive and 114 were baseline CT negative. Baseline CT positivity was associated with age distribution, and baseline CT positivity was most common in patients aged >60 years (P < 0.001), but not with vaccination status or gender. The results of the subgroup analysis according to age distribution indicated that different age distribution subgroups had different vaccination statuses, and the majority of patients aged <18 years and >60 years were unvaccinated (90.5%, 19/21, and 57.3%, 63/110, respectively). In contrast, most patients aged 18–60 years had received two doses of the vaccine (61.1%, 55/90) (P < 0.001). Different age distribution subgroups had different clinical infection types. Asymptomatic and mild cases were most common in patients aged ≤60 years, and moderate and severe or critical cases were most common in patients aged >60 years. For baseline CT-positive patients, the extent of lung involvement was associated with age, vaccination status, and chronic disease. The number of involved lobes was higher in patients who were unvaccinated or who had received one injection, who were aged >60 years or had chronic disease. There was a statistical difference in CT semi-quantitative scores between the different age subgroups. Compared with patients aged < 60 years, patients aged >60 years had higher semi-quantitative scores (P < 0.001). However, there was no statistical difference between the different vaccination groups.

CONCLUSIONS:

Age had a large effect on baseline CT positivity, CT characteristics, and semi-quantitative CT scores in patients infected with the Delta variant.
Characteristics of cardiac injury complicating with acute kidney injury and mortality risk in coronavirus disease 2019 (COVID-19) patients
Authors: Li Hongmei , Dai Hui , Huang Renjun , Shang Yalei , Huang Jianan , Zeng Daxiong , Tian Weizhong , Hu Chunfeng , Li Yonggang
Published: March 2023

Objectives:

This study aimed to identify the clinical features of cardiac injury complicating with acute kidney injury (AKI) and its risk for a fatal outcome in patients infected with coronavirus disease 2019 (COVID-19) pneumonia.

Methods:

Initial signs and symptoms and clinical laboratory, radiological, and treatment information were obtained from seven hospitals in China from January 23, 2020, to March 15, 2020.

Results:

Of 438 patients, 36 (8.22%) displayed isolated cardiac injury, 17 (3.88%) had isolated AKI, and 17 (3.88%) displayed cardiac injury complicating with AKI. Compared with patients without cardiac injury or AKI, patients with isolated cardiac injury, isolated AKI, and cardiac injury complicating with AKI were older (55, 65, 74 vs. 48 years, P < 0.0001) and critically severe. More patients displayed fatigue, dyspnea, and comorbidities in the group with cardiac injury complicating with AKI. Moreover, the indexes reflecting myocardial, renal, liver, and coagulation dysfunctions and infection-related factors were significantly different among the four groups. After adjustment for covariates, patients with cardiac injury complicating with AKI had a higher hazard ratio for mortality (6.64; 95% confidence interval, 1.51–29.30).

Conclusion:

Cardiac injury complicating with kidney injury significantly increased the risk for in-hospital mortality in COVID-19 pneumonia patients. Therefore, early detection at admission and careful monitoring of myocardial and renal injury through biomarkers during hospitalization is recommended to reduce the harm to patients.
Retinal nerve fiber layer thickness and peripapillary vasculature of post-COVID-19 patients with and without olfactory/gustatory dysfunction symptoms
Authors: Kılıçarslan Oğuzhan , Çebi Aslıhan Yılmaz , Uçar Didar
Published: March 2023

PURPOSE:

We aimed to compare retinal nerve fiber layer (RNFL) thickness and peripapillary vessel density values between COVID-19 patients with or without olfactory/gustatory dysfunction symptoms and healthy controls.

MATERIALS AND METHODS:

We evaluated RNFL and radial peripapillary capillary vessel density (RPC-VD) values of 41 patients who had COVID-19 history and age- and gender-matched control group including 31 healthy individuals with optical coherence tomography angiography. First, post-COVID-19 group’s and control group’s RNFL and RPC-VD values were compared, then post-COVID-19 patients were divided into subgroups according to the presence (subgroup-A) and absence (subgroup-B) of olfactory/gustatory dysfunction symptoms, and same parameters were analyzed for subgroups.

RESULTS:

Forty-one eyes of 41 post-COVID-19 patients and 31 eyes of 31 age- and gender-matched healthy controls were included in this cross-sectional study. In RNFL analysis, inferior sector thickness was found significantly lower in post-COVID-19 patients by comparison with control group (P = 0.041). In subgroup analyses, COVID-19 patients who first presented with olfactory/gustatory dysfunction symptoms had higher peripapillary and whole image optic disc capillary density (P = 0.011 and P = 0.002) compared to those who had not had these symptoms.

CONCLUSION:

Lower RPC-VD and RNFL thickness were detected in COVID-19 patients compared to healthy controls. Higher Disc-VD values were found in COVID-19 patients with chemosensorial dysfunction (CSD) symptoms compared to those who had not had these symptoms probably due to milder disease course in COVID-19 with CSD. Sectorial RNFL attenuation in COVID-19 might have occurred secondary to peripapillary capillary circulation defect.
Dyskursy naukowe jak VR-owa impreza? Recenzja książki Joanny Walewskiej-Choptiany Cyfrowa dekada. Związki sztuki i technologii w latach 1960–1975
Authors: Jarosz Ewelina
Published: March 2023

Joanna Walewska-Choptiany, Cyfrowa dekada. Związki sztuki i technologii w latach 1960–1975, Wydawnictwo Naukowe Uniwersytetu Mikołaja Kopernika, Toruń 2021, ss. 389.
Creating Climate Conscious Players: Final Fantasy VII’s Ecoactivist Fan Communities
Authors: Barton Andrew
Published: March 2023

This paper examines the ecocritical message espoused by characters in Final Fantasy VII and Final Fantasy VII Remake and uses affect theory to better understand fan response to these beliefs. From there, I note the publishing company, Square-Enix, recently declared interest in pursuing NFT technology as a potential revenue stream despite the environmental concerns this technology brings, which resembles the villainous organization Shinra in these games. Fan response Square-Enix’s NFT projects indicates how fans may identify with and absorb the ideologies of characters in video games, even when that ideology sets the fans in opposition with the companies behind the original game(s).
Strategia zarządzania informacją jako instrument ochrony przestrzeni informacyjnej państwa (case study: Ukraina)
Authors: Piechota Grażyna
Published: March 2023

Information Management Strategy as a Tool to Protect the State’s Information Space (Case Study of Ukraine)

The aim of the article is to analyze the Information Security Strategy of Ukraine in the context of the current documents on that matter. The document presents exogenous and endogenous threats to the information environment of the Ukrainian state and proposes measures to combat them: protection of the information space, ensuring effective strategic communication of Ukraine, development of media education, shaping Ukrainian civic identity, and information reintegration of Ukrainian citizens living in the temporarily occupied territories. The actions taken by the Ukrainian society after the aggression of the Russian Federation in Ukraine on February 24, 2022 prove that the implementation of strategic documents on information security is highly effective.
Rancangan Sensor Cahaya Sebagai Penerangan Jalan Otomatis Pada Miniatur Komplek Pendidikan Yayasan Al- Ma’arif NU
Authors: Saputra Rizky , Safitri Nellyana , Deolika Agatha
Published: March 2023

Saat ini cukup banyak digunakan hal yang mudah dan simple untuk berbagai keperluan pekerjaan manusia. Dalam hal ini sistem kontrol sebagai suatu disiplin ilmu yang memungkinkan diterapkannya otomatisasi. Pada penelitian menggunakan sensor cahaya sebagai alat otomatis menghidupkan dan mematikan lampu . alat yang di gunakan pada penelitian ini adalah Sensor Cahaya LDR. Photoresistor digunakan sebagai alat utama pada penelitian ini. lalu Transistor NPN TIP120 adalah transistor yang sering di gunakan dan di maanfaatkan sebagai saklar otomatis yang menyambungkan mikrokontroler ke komponen yang memerlukan tegangan tinggi. Hasil akhir dari penelitian ini adalah sistem pencahayaan otomatis pada jalan komplek Pendidikan Yayasan Al-Ma’arif yang mengontrol lampu berdasarkan ada/tidaknya cahaya dari sensor di sekitar lampu, yang kemudian menjadi otomatis. Lampu akan menyala otomatis saat sensor tidak mendapat cahaya, begitu juga sebaliknya lampu akan mati otomatis saat sensor mendapatkan cahaya.
Analysis of Bandwidth Management Quality of Internet Network Services at the Shanti Bhuana Institute
Authors: Sari Maya , Ningki Carolus , Rosa Fenni , Novando Kristian , Mukin Yohanes Duhin
Published: March 2023

To test the quality of internet network services at the Shanti Bhuana Institute and the addition of two study programs, namely Information Technology S1 and PGSD S1 in August 2020. During this pandemic, advances in information technology, especially in the internet sector, network service quality, and system services are very important, especially when it comes to accessing online applications like Zoom or Google Meet. The internet network of the Shanti Bhuana Institute was initially only 10 Mbps, but was later increased to 130 Mbps. The author will analyze the quality of bandwidth management of internet network services at the Shanti Bhuana Institute. Based on these problems, the authors will use the FDMI (Fixed Daily Measurement Interval) and Qos (Quality of Services) methods to assess the quality of bandwidth management of internet network services at Shanti Bhuana Institute. The findings of this study can be used to make physical recommendations for the internet network of the Shanti Bhuana Institute. Based on measurements and tests carried out on the internet network at the Shanti Bhuana Institute, a throughput value of 6721 kb/s was obtained. This figure is part of the very good category index. Meanwhile, the amount of packet loss is very low (0.0001%), so it is classified as very good, the delay obtained is 50.338539 ms which is included in the very good category, while the jitter value is 52.97569 ms which is included in the good category.
O BRINQUEDO QUE NÃO É BRINQUEDO E SUAS POSSIBILDIADES
Authors: Sausen Solange Lisiane , Cunha Jaqueline da
Published: March 2023

Este artigo aborda um assunto contemporâneo, o qual trata sobre a questão do brincar com brinquedos que não são brinquedos e suas possibilidades, no dia a dia no contexto escolar. Aos olhos de uma criança esses materiais são fascinantes, pois possibilitam a ela explorar, elaborar hipóteses, criar seu próprio brinquedo e brincadeira, estimulando a criatividade e imaginação.
SUPORT SYSTEM DECISION (DSS) PRESMA ELECTIONS OF UNIKI USING SIMPLE ADDITIVE WEIGHTHING METHODE (SAW)
Authors: Nunsina Nunsina , Fadhilah Cut , Kulbahri Kulbahri
Published: March 2023

ABSTRACT Since minister lukman (2014-2019) and judge saifuddin (2014-2019) presented the discourse on religious censorship, the ministry of religions has continued to develop knowledge and strengthen religious censorship narratives through various digital platforms. The study focuses on the Ministry of the Republic of Indonesia's increased religious censorship on YouTube, the most popular social media platform for today's Internet users. The study draws several conclusions by combining a content analysis method with a descriptive analysis method. First, the intensity with which the YouTube channel is used to strengthen religious censorship issues needs to be increased. Only 15 (4.71%) of the 318 videos uploaded to the ministry of religion's YouTube account contain content on censorship and religious harmony. The annual frequency remained low, and there was no content on moderation and religious harmony in 2019. Second, religious censorship is still applied primarily to intellectuals who have not reached out to millennials. Its progress in eradicating negative issues related to the government's religious regulation program remains limited. Third, reaction data on censored and harmonized video content remains low, according to warganet. According to research, netizens prefer the term harmony to moderation. This suggests that the Indonesian people prefer harmony in general, but there are still some interpretations or negative impressions of the term "moderation" carried by the ministry of religions. Keywords: Methode (SAW), Student presidency candidate (PRESMA), Decision-making support systems
Design & development of an acqua-robotic system for detecting objects in water
Authors: Charan Reddy N  , Gopinath C  , Jayashree K  , Revati Hiremath  , Pavithra G  , Sindhu Shree M  , T.C.Manjunath  , Aditya T.G  , Sandeep K.V  , Rajashekar M. Koyyeda  , Suhasini V.K  , Vijayakumar K.N
Published: March 2023

The purpose of this study is to build and implement an underwater robot called an Aquabot that can search for potential human presence. This robot is anticipated to be incredibly helpful in operations for underwater person detection during water accidents. The security at these borders is extremely important, and monitoring the marine borders is a very challenging undertaking. Marine exploration is required to comprehend the worldwide climatic and environmental changes. This initiative contributes to different data collection, weather monitoring, and pH sensing fields of research. Disaster prevention, including earthquake and tsunami mitigation, is possible with this data. Many locations lack garbage disposal facilities. As a result, throwing trash into neighbouring bodies of water has grown to be a serious problem. Since this kind of dumping harms the environment, Aquabot offers cleaning, weather monitoring, pH sensing, and other applications.
Serum levels of chemical elements and carious lesions in children after antitumor therapy
Authors: Zhukovskaya E. V. , Savko S. A. , Obukhov Yu. A. , Karelin A. F. , Goncharov A. P. , Zhernov Yu. V. , Skalny A. V.
Published: March 2023

Aim. To study serum concentrations of trace and macro elements and their correlations in children and adolescents after antitumor therapy, depending on the presence or absence of caries.

Materials and methods. The study included 98 patients aged 4 to 17 years who were in remission after an antitumor therapy performed for acute leukemia or lymphomas. Patients with carious tooth lesions were included in group 1 (n = 34) and without caries – in group 2 (n = 64). We used inductively coupled plasma mass spectrometry to calculate the content of essential, conditionally essential and toxic elements in blood serum. The median and interquartile range were calculated, the Mann-Whitney U-test was applied to compare groups, and the Kendall rank correlation coefficient (τ) was calculated for tandem elements.

Results. In both groups, the concentrations of the studied elements were within the reference ranges. In group 1, compared with group 2, higher concentrations of potassium, arsenic, iodine and boron and lower concentrations of lithium and tungsten (p < 0.05) were noted. There were no differences in the concentration of phosphorus, calcium, magnesium, manganese, gold, silver, platinum, aluminum, beryllium, bismuth, cadmium, cobalt, chromium, copper, iron, mercury, lithium, molybdenum, nickel, rubidium, antimony, tin, vanadium, zinc, zirconium and thallium between the groups. Significant correlation coefficients in both groups were obtained for the iron/manganese tandem (τ = 0.24, p < 0.05). Different values of τ were got for nickel/ manganese, cobalt/iron, manganese/phosphorus, beryllium/lithium tandems: τ = 0.342 and τ = 0.14; τ = 0.363 and τ = 0.033; τ = –0.111 and τ = –0.326; τ = –0.365 and τ = 0.42, respectively, for groups 1 and 2.

Conclusion. In patients in remission after antitumor therapy, an association of caries with an increase (within reference values) in the concentration of essential (potassium, iodine) and conditionally essential elements (arsenic, boron), a decrease in the concentration of lithium and tungsten; as well as a change in the ratio of nickel/manganese, cobalt/iron, manganese/ phosphorus and change the direction of the correlation in the beryllium/lithium tandem was revealed.
Distal middle cerebral artery aneurysm manifestation against the background of COVID-19
Authors: Litvinenko D. V. , Litvinenko E. A. , Tkachev V. V. , Muzlaev G. G.
Published: March 2023

A significant part of distal cerebral aneurysms belongs to the category of complex. Traditional methods of shutting down such aneurysms are not applicable. Treatment tactics remain a subject of debate. The presence of COVID-19 complicates the course of the disease and complicates the routing of the patient to a specialized hospital.

Description of the case. A 36-year-old man with COVID-19 developed an ischemic stroke in the territory of the right middle cerebral artery (MСA), clinically manifested by dysarthria and pronounced left-sided hemiparesis. Cerebral angiography (CAG) revealed thrombosis of the parietal branch of the M2 segment of the right MСA with distal filling of the channel from the territory of the left MСA. After 3 months, according to the control CAG, recanalization of the M2 segment of the right MСA and fusiform aneurysm of this segment of the artery were diagnosed. To turn off the aneurysm, an intra-intracranial anastomosis was applied between the upper and lower M2 segments of the right MСA and an extra-intracranial anastomosis between the parietal branch of the right superficial temporal artery and the cortical branch from the territory of the compromised M3 segment of the MСA, the aneurysm was excised. The postoperative period was complicated by reinfection of SARS-CoV-2. After the treatment, the patient was discharged in a satisfactory condition without neurological deficit.

Discussion. Resection of an aneurysm with revascularization of the distal bed can be considered as the method of choice in patients with distal aneurysms if it is impossible to apply traditional clipping. The presence of COVID-19 infection increases the risk of thrombotic complications, imposes increased requirements on the technique of performing vascular anastomoses.
Tendencias de Web 2.0 como plataforma tecnológica para la innovación en el pensamiento pedagógico docente
Authors: Pinto Vásquez Karina Noslen , Vargas Aponte Juan Pablo , Vargas Aponte Sorangel José
Published: March 2023

El objetivo general del estudio fue analizar la aplicación de las tendencias de Web 2.0 como plataforma tecnológica para la innovación en el pensamiento pedagógico docente. Se fundamenta en una investigación de tipo descriptiva con diseño transversal, documental. Para la recolección de la información, se utilizaron registros de fuentes primarias tales como libros y artículos de revistas científicas, haciendo análisis de información a través de lectura de documentos. Se concluye que la utilización de las tendencias que la Web 2.0 ofrece para ser implementadas como herramientas de apoyo en el ámbito educativo son diversas. El entorno lo constituye el internet como una red social, que facilita la participación del estudiante universitario, junto con la reflexión de su experiencia interactiva como formas de acceder al conocimiento como autocrítico, aportando sus ideas de manera libre. Las plataformas virtuales aplicadas en la educación, son implementadas desde un modelo constructivista, donde la cooperación con la interacción se transforma en elementos claves para el aprendizaje autónomo, donde los estudiantes se convierten en protagonistas de su formación desarrollando la independencia de los saberes compartidos. Los entornos virtuales para la docencia universitaria son creados con el propósito de guiar el aprendizaje interactivo, a fin de facilitar la creación de conocimientos por parte de los estudiantes. Cuando se habla de innovación en el pensamiento pedagógico docente, se hace referencia a los cambios necesarios que rompen con el modelo tradicional de la didáctica utilizada, ya que, las transformaciones incluyen prácticas educativas mediadas por la tecnología.
Saturniidae (Lepidoptera: Bombycoidea) do Cerrado central do Maranhão
Authors:   , Santos Alberico Alves dos
Published: March 2023

O Cerrado, o segundo maior bioma brasileiro com rica diversidade de espécies endêmicas, tem cerca de 46% de sua mata nativa convertida em cultivos agrícolas e pastagem e, por isso, considerado área prioritária para conservação. O levantamento da fauna é importante para se conhecer e monitorar a biodiversidade. Um total de 3454 espécies de Saturniidae foi registrado no mundo com cerca de 500 espécies no Brasil, sendo 202 espécies no Cerrado brasileiro. O objetivo desse estudo foi estudar a flutuação populacional e atualizar a distribuição geográfica e a ocorrência de novos registros de espécies de Saturniidae e de suas plantas hospedeiras no bioma cerrado do estado do Maranhão e região Nordeste do Brasil. Espécimes de Saturniidae foram coletados no Parque Estadual do Mirador, Maranhão, Brasil em noites de lua nova ou minguante com armadilha luminosa, entre 18:00 e 06:00 horas de outubro de 2006 a março de 2012, em meses alternados, dependendo do período lunar favorável. Um total de 49 espécies de 30 gêneros foi coletado, sendo 19 novos registros de espécies para o Maranhão e nove novos registros de espécies para a região Nordestes, aumentando estes números para 88 e 128, respectivamente. Espécies de 49 famílias de plantas foram obtidas de literatura como hospedeiras das espécies de Saturniidae coletadas, aumentando a necessidade de preservação ambiental para se manter a diversidade de espécies desses insetos no cerrado brasileiro. O número de espécimes coletados foi maior em fevereiro, março, outubro e novembro, no período chuvoso, indicando que a ocorrência das espécies de Saturniidae varia com os fatores climáticos e essas informações aumentam o conhecimento da flutuação populacional desses insetos no Cerrado do Brasil. Palavras-chave: Biodiversidade. Conservação. Mariposas.
Modelagem de vazões máximas e mínimas com base em aprendizado de máquina
Authors:   , Silva Carla Larissa Fonseca da
Published: March 2023

O comportamento hidrológico de diversas bacias hidrográficas tem sido afetado por fatores como uso e cobertura da terra, demanda hídrica e mudanças climáticas, levando ao comprometimento da disponibilidade hídrica ou à ocorrência de eventos extremos de vazão. Esse comportamento pode ser avaliado por meio de testes não-paramétricos, que mostram a tendência de variáveis hidroclimatológicas de interesse para a gestão ambiental. Além dessa análise, em estudos hidrológicos tem-se a necessidade de aumentar os horizontes de previsão da vazão, principalmente em bacias com frequente ocorrência de eventos de alta magnitude. Assim, objetivou-se compreender o comportamento hidrológico e suas possíveis mudanças nos últimos anos na bacia hidrográfica do rio Muriaé, além de modelar a vazão com base em diferentes cenários de dias de antecedência na sua previsão. No Capítulo 1 foram aplicados testes não-paramétricos para a identificação de tendências de mudança no comportamento hidrológico em anos/meses em diferentes níveis de significância, bem como a investigação de fatores que poderiam estar associados às mudanças. Os testes não-paramétricos mostraram tendência negativa dos valores extremos de vazão, principalmente no período de estiagem, com destaque para o mês de outubro. Na análise dos fatores, a precipitação e a demanda hídrica apresentaram indicativos de influência no regime de vazões, diferentemente do uso e cobertura da terra. Os diferentes métodos estatísticos permitiram encontrar resultados satisfatórios sobre o comportamento hidrológico da bacia, enquanto as análises dos fatores climáticos e antrópicos possibilitaram conhecer as possíveis influências nas mudanças de tendência da vazão. No Capítulo 2 foi explorada a utilização de técnicas de Aprendizado de Máquina como o Modelo Linear Generalizado (GLM), as Splines de Regressão Adaptativa Multivariada (MARS) e o Random Forest (RF) na previsão da vazão considerando cenários de dados com um, dois e três dias de antecedência. A modelagem mostrou que todas as técnicas tiveram um desempenho muito bom na previsão das vazões com um dia de antecedência. Por outro lado, houve uma redução do desempenho com o aumento do horizonte de previsão, principalmente no cenário de três dias. Em todos os períodos de antecedência a técnica RF se mostrou superior às demais, mesmo que tenha apresentado subestimação das vazões máximas. A modelagem em diferentes cenários de previsão com Aprendizado de Máquina mostrou a aplicabilidade dos algoritmos na previsão da vazão, principalmente em bacias com ocorrência elevada de eventos máximos de vazão, com possibilidade de serem utilizados nos sistemas de alerta e, assim, reduzir os impactos socioambientais causados por esses eventos. Palavras-chave: Comportamento hidrológico. Modelagem hidrológica. Períodos de antecedência.
Synthesis of macrocyclization cyclophanes and their metal complexes, characterization and antimicrobial activity
Authors: TURKYİLMAZ Murat , DÖNMEZ Murat , ATES Murat
Published: March 2023

Due to their chemical properties, cyclophane-type compounds constitute an interesting organic chemistry class. In the structure of all cyclic compounds, macrocyclization is the most
critical issue for high-efficiency synthesis. Especially with a small cyclophane structure, the
experimental steps are more complicated than with a prominent cyclophane structure. In
this manuscript, three different material groups were applied to synthesize silver cyclophane
compounds for smart drug properties. In the first material group, 5,6-dimetil-1H-benzo[d]
imidazole (1) and 2,6-bis(chloromethyl)pyridine (2) were reacted to form 5,6-dimethyl-1-
((6-((5,6-dimethyl-1H-benzo[d]imidazole-1-il)methyl)pyridine-2-il)methyl)-1H-benzo[d]
imidazole compound (3). In the second material group, ethyl 2-bromoacetate (4) reacted to
different nitrogen atoms of the cyclophane compound to form a symmetric carbene compound, which is water-soluble (5). In the third material group, the silver (I) and palladium
(II) metal complexes were synthesized due to the reaction with silver(I) oxide (6) and palladium (II) chloride (7). Antimicrobial activities of the carbene compounds and silver and
palladium complexes (5, 6, and 7) were investigated against bacteria and fungal in more detail.
Silver (I) complex (6) shows an antimicrobial agent when mixed with microorganisms, such
as Gram-positive, Gram-negative, and fungal, but this property has not been observed in the
palladium (II)-carbene complex (7).
PECULIARITIES OF EPIZOOTOLOGY OF MULLERIOSIS OF SHEEP AND GOATS IN THE REPUBLIC OF BELARUS AND IMPROVEMENT OF ITS DIAGNOSTICS METHODS
Authors: Mironenko V. M. , Konakhovich I. K.
Published: March 2023

The data on the infection of animals with muelleriosis and pathogens of other parasitoses of the respiratory and digestive systems in sheep and goat farms of the Republic of Belarus have been established. The larvamigration (pipette) method for detecting the larvae of Muellerius capillaris, which is superior in efficiency to the existing meth-ods, has been developed.
Determinants of Hypertension in Adolescents and Adults (18-44 years) at the Karang Panjang Health Center, Ambon City
Authors: Lawalata Ivy Violan , Talarima Bellytra , Subagiyo Bella Agustina Adinda
Published: March 2023

The prevalence of hypertension in Indonesia in the young age group based on the 2018 Basic Health Research has increased significantly to 13.2% in the 18-24 year age group, 20.1% in the 25-34 year age group and 31.6% in the 25-44 year age group compared to 2013. The purpose of this study was to determine the risk factors for family genetic history, obesity, physical activity and psychological stress with the incidence of hypertension. The research method used is Case Control. The number of samples in this study were 146 respondents with details of 73 cases and 73 controls. The data analysis performed was univariate and bivariate with the chi-square test. The results of the analysis showed that family genetic history was a determinant of hypertension with an Odds Ratio (OR) = 72,696 confidence level 95% CI value LL and UL = 22,692 – 232,890; Obesity is a determinant of hypertension with Odds Ratio (OR) = 5.056 confidence level 95% CI value LL and UL = 2.112 – 12.101; Physical activity is not a determinant of hypertension with Odds Ratio (OR) = 1.059 confidence level 95% CI value LL and UL = 0.545 – 2.060; The psychological condition of stress is a determinant of the incidence of hypertension with an Odds Ratio (OR) value = 10,815, 95% CI confidence level, LL and UL values = 4,377 – 26,726. In conclusion, family genetic history, obesity and psychological stress conditions are determinants of the incidence of hypertension. It is recommended for adolescents and adults aged 18-44 years to be able to control eating patterns, carry out regular physical activity and control stress levels and carry out routine blood pressure control every month at health services closest.
Formulation and Evaluation of Gastro Retentive Drug Delivery System of Domperidone Mouth Dissolving Tablet by using Super Disintegrating Agents
Authors: Rupali Patel , Nikita Upadhyay , Sunita Sonartiya , Sourabh Jain , P.K. Dubey
Published: March 2023

Direct compression method can be considered as an important method for the formulation of fast dissolving tablets of Domperidone compare to wet granulation method. The rank order for the best 3 formulations is F2>F1. Formulation F2 having DCP as the super disintegrant is the best formulation of all. Higher the concentration of the lubricating agent (Magnesium Stearate or Talc), higher will be the disintegration time. Formulation having the better Super disintegrants (Ac-Di-Sol) will have better in vitro disintegration time and dissolution along with lesser friability and weight variation. Thus, it may be concluded that the fast-dissolving tablets of Domperidone can be successfully prepared and undoubtedly the availability of various technologies and manifold advantages of fast dissolving tablets will surely enhance patient compliance and its popularity in the near future.
SCAFFOLDS MAGNÉTICOS DE QUITOSANA E/OU HIDROXIAPATITA PARA REGENERAÇÃO DE TECIDO ÓSSEO: UMA REVISÃO SISTEMÁTICA
Authors: Garcia Guedes Danyelle , Cunha Maria Eduarda , Gomes Araújo Renally , Silva Adriano Lima da , Guedes de Lima Marcelino , Gondim Nepomuceno Fabio , Figueiredo de Melo Costa Ana Cristina
Published: March 2023

A incorporação e a exploração de partículas com propriedades magnéticas como um potencializador dos processos de regeneração óssea por meio de scaffolds tridimensionais tem sido uma estratégia na engenharia de tecido ósseo, o que possibilita obtenção de estruturas com capacidade responsiva à estimulos externos, inteligentes e bioativos. Nesse sentido, este artigo propõe uma revisão sistemática baseada em artigos de pesquisa primária com foco em scaffolds magnéticos de quitosana e/ou hidroxiapatita na regeneração do tecido ósseo. Com este fim foi realizada uma busca nas plataformas Science Direct, Pubmed e Web of Science no período entre 2020 a 2022 e a revisão foi conduzida por meio do software Start. Critérios de inclusão foram utilizados para a seleção dos periódicos mais relevantes e observou-se que dentre as estratégias de scaffolds magnéticos de quitosana e/ou hidroxiapatita reportadas, as mais significativas envolveram indução da osteogenese endocondral, aumento nas vias de formação de vasos sanguíneos no tecido ósseo lesado, sistema de liberação de fármaco, entrega de fatores de crescimento e combate de células tumorais. Os resultados demonstraram esses sistemas apresentam potencial promissor de aplicação em regeneração óssea.
The Effect of Storage at -20°C and -80°C on HbA1c Measurements in Whole Blood Samples Analysed Using Bio-Rad D-10
Authors: T. Ibrahim T. Zaharah , Samsudin Intan Nureslyna , Nasuruddin Alia Nasriana , C. Thambiah Subashini
Published: March 2023

Introduction: Glycated haemoglobin (HbA1c) is a test commonly measured in many clinical laboratories to monitor and diagnose diabetes mellitus (DM). The laboratory in Hospital Tengku Ampuan Afzan (HTAA) receives HbA1c samples internally and from several other hospitals and clinics in the state of Pahang, at which, before transportation and analysis, the samples are often stored. This study determined the stability of HbA1c samples following different storage temperatures and duration for up to 30 days. Method: Whole blood samples for HbA1c analysis were collected from 222 healthy blood donors and type 2 DM (T2DM) patients. Each sample was prepared into four aliquots, which were then stored at temperatures -20°C and -80°C. HbA1c analyses were performed at baseline, days 15 and 30 using ion-exchange high-performance liquid chromatography (HPLC) assay technique on Bio-Rad D-10 analyser. HbA1c levels following sample storage were compared to the levels at baseline. Results: The baseline HbA1c (mean±SD) was 6.6±2.2%. At -20°C of storage, the HbA1c levels decreased with a mean difference of 0.1% and 0.3% on days 15 and 30, respectively. Storage at -80°C resulted in a mean difference of 0.1% on day 15 whilst no change was noted on day 30. The number of samples that showed clinically significant HbA1c change (defined as a change of >0.5%) was less for the samples stored at -80°C (4.5%) as compared to -20°C (23%). Conclusion: HbA1c concentration is affected by temperature and duration of sample storage. In instances where prolonged storage of HbA1c samples is expected, storage at -80°C is preferable.