bluuebunny/crossref_metadata_2025 huggingface dataset:
Today’s Students, Tomorrow’s Physicians: Opinions on Enacted and Prospective Health Care Policies
Authors: Rook Jordan M. , Fox Jacob A. , Feuerbach Alec M. , Blum James R. , Henschen Bruce L. , Oot Antoinette R. , Pierce Jacob B. , Davey Cynthia S. , Winkelman Tyler N. A.
Published: April 2020

Future physicians will be key stakeholders in the formation, implementation, and success of health care policies enacted during their careers, though little is known of their opinions of enacted and proposed policies since the 2016 U.S. presidential election. This study aimed to understand the opinions of medical students related to policies including, but not limited to, protections for people with pre-existing conditions, a public option on the private exchange, and single-payer health care. Online surveys were completed by 1,660 medical students at 7 U.S. medical schools between October 2017 and November 2017. The authors used multiple logistic regression to examine associations between student characteristics and support of policies. In total, 1,660 of 4,503 (36.9%) eligible medical students completed the survey. A majority of respondents identified 4 extant Affordable Care Act policies as important, including its protections for patients with pre-existing conditions (95.3%) and Medicaid expansion (77.8%). With respect to prospective reforms, 82.6% supported a public insurance option, and 70.5% supported a single-payer health care system. Only 2.2% supported reducing funding for Medicaid. Although views varied by sex, anticipated specialty, and political affiliation, medical students largely supported prospective policies that would expand insurance coverage and access to health care.
Designing genetic impact assessment for crossbreeding with exotic beef breeds in mixed farming systems
Authors: Widi Tri Satya Mastuti , Udo Henk , Oldenbroek Kor , Budisatria I Gede Suparta , Baliarti Endang , der Zijpp Akke van
Published: April 2020

A genetic impact assessment (GIA) methodology is developed, consisting of consultation of stakeholders, identification of issues and assessment of associated indicators, for crossbreeding with exotic beef breeds in smallholder mixed farms. The GIA is implemented in two case studies of crossbreeding with Limousin and Simmental in Madura and Central Java, Indonesia. Consultation of stakeholders ( n = 421) in focus group discussions yielded the issues that should be taken into account in a GIA. Farmers identified economic benefits, feed availability, cattle management, animal’s performances, additional functions of cattle, and health and fertility as issues. Policymakers mentioned the production of beef as the main issue while scientists called for environmental quality and maintaining local farm animal genetic resources as issues. Indicators to characterize these issues in a GIA were deducted from literature; determination of the indicators was based on data sampled on 97 farms, keeping local Madura or Limousin crossbreds, in Madura and 252 farms and keeping local Ongole or Simmental crossbreds, in Central Java. The GIA showed that crossbreeding contributes to increased meat production at the national level; however, it does not necessarily guarantee improvements in economic benefits at farm level nor environmental performances.
Variation in shallow sandy loam porosity under the influence of shallow coal seam mining in north-west China
Authors: Cui Fan , Du Yunfei , Chen Baiping , Zhao Yuxuan , Zhou Yingqing
Published: April 2020

To study the influence of coal mining on the porosity of shallow sandy loam under conditions of shallow seam mining in thick, loose layers in north-west China, a typical surface sandy loam stratum in Shaanxi Province was taken as the study area, and experiments were performed to test the variation of soil porosity at different depths of 0–10 m in strata before, during and after mining therein. The experimental results demonstrate that the overall average porosities in the disc-shaped edge area, the disc-shaped edge area to the disc-shaped basin bottom area and the disc-shaped subsidence centre area of shallow sandy loam in mining increased by (23.51, 18.07 and 22.61%) respectively compared with that before mining. Mining meant that the soil porosity in the period of stable subsidence after mining changed significantly in the disc-shaped edge area and the disc-shaped edge to the disc-shaped basin bottom area. The disc-shaped edge area shows a trend of slowly rising porosity with the increase of depth, and the disc-shaped edge area to the disc-shaped basin bottom area shows a trend of gradually increasing first and then gradually becoming stable. Although the porosity in the central area of disc-shaped subsidence increased before mining, its trend was similar to that before mining. Although the change in soil porosity in the period of post-mining settlement stability is greater than that before mining, it is best fitted by a quintic polynomial. In general, the rate of change of soil porosity in the study area shows similar trends with depth. It showed a U-shaped variation that first decreased, stabilised for a distance and then gradually increased. This study provides theoretical support for surface soil remediation and ecological environment restoration in coal mining areas.
Constructing a risk prediction model for anastomotic leakage after esophageal cancer resection
Authors: Sun Zhong-Wen , Du Hui , Li Jia-Rui , Qin Hui-Ying
Published: April 2020

Objective

The purpose of this study was to investigate a newly constructed risk prediction model for anastomotic leakage after esophageal cancer resection.

Methods

A retrospective survey of 205 patients who underwent esophageal cancer resection was conducted using a self-designed questionnaire. The influencing factors were explored by single factor analysis, and a logistic regression analysis was performed to construct the prediction equation. A receiver operating characteristic curve was used to evaluate the model.

Results

The incidence of anastomotic leakage after esophageal cancer resection was 11.73%. There were five independent risk factors entered into the regression equation. The risk prediction equation was Z = 0.108 × age + 2.011 × preoperative chemotherapy history + 3.007 ×incision redness/exudation + 2.632 × pleural effusion + 1.934 × increased white blood cell count − 12.304. According to the receiver operating characteristic curve test, the area under the curve was 0.946, the sensitivity was 0.833, the specificity was 0.912, and the Youden index was 0.745.

Conclusion

The risk model of anastomotic leakage after esophageal cancer resection had a good predictive effect that was of significance for guiding clinical observation and early-screening.
Duration of dual antiplatelet therapy in patients with acute coronary syndrome undergoing drug-eluting stent implantation: A meta-analysis
Authors: Geng Xue , Zhang Ya-Nan , Cui Wei
Published: April 2020

Objective

This meta-analysis was performed to evaluate the optimal discontinuation of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation in acute coronary syndrome (ACS) patients.

Methods

A systematic search was conducted without language restrictions using PubMed, the Cochrane Library, and Clinical Trials.gov from January 2008 to July 2019. Studies that met the following criteria were included: (1) randomized trials that compared DAPT durations of <12 months (“short DAPT”) or ≥12 months (“long DAPT”); (2) studies that included data on patients with ACS; and (3) studies that included data on outcomes. The outcomes were pooled using the Mantel–Haenszel model, generating relative risk (RR) and 95% confidence intervals (CI). Statistical heterogeneity was evaluated using the Cochrane Q statistic P-value and I2 value. Publication bias was assessed by visually inspecting the funnel plots.

Results

Eight studies comprising 10,537 participants were included in the analysis. The primary endpoint was not different between short-term and long-term DAPT (RR, 1.11; 95% CI, 0.92–1.34).

Conclusion

A meta-analysis of the available evidence suggests that DAPT can be reduced to 3 or 6 months without increasing the risk of cardiovascular and cerebrovascular events in patients with ACS who are undergoing DES implantation.
Errors of Analysis in Distance Assessment: Effects of Vertical on Horizontal Components
Authors: Dopkins Stephen
Published: April 2020

(a) Participants indicated, for pairs of circles whose locations varied on the horizontal and vertical axes of a frontal plane, whether the horizontal distance between the circles exceeded a target horizontal distance. The error rate depended on the vertical as well as the horizontal distance between the circles. (b) Participants indicated, for pairs of circles that were varying horizontal (or vertical) distances and a constant vertical (or horizontal) distance apart in a frontal plane, whether the horizontal (or vertical) distance between them matched a target horizontal (or vertical) distance. Incorrect “match” responses were more likely if the horizontal (or vertical) distance between the circles was less than as opposed to greater than the target distance. The results suggest that distance judgments for pairs of stimuli varying on the horizontal and vertical axes are based on the overall distance between the stimuli, with the relevant axis given more weight than the irrelevant axis in assessment of the distance. The results do not support the view that that such distance judgments are based on the relevant distance between the stimuli, with the relevant and irrelevant axes being erroneously interchanged on some iterations of the assessment process.
Looking through the Perceptions of Blinds: Potential Impacts of Connected Autonomous Vehicles on Pedestrians with Visual Impairment
Authors: Azizi Soldouz Sina , Hasnine Md Sami , Sukhai Mahadeo , Nurul Habib Khandker
Published: April 2020

The paper investigates the impacts and barriers posed by connected autonomous vehicles (CAVs) for pedestrians with visual impairment. This study uses a customized web-based survey of visually impaired people from Canada and abroad. Collected data are used to estimate econometric models to identify the critical factors that affect the level of trust in CAVs and the preference for using CAVs from the visually impaired individuals’ perspective. Separate models are estimated for Canadian and non-Canadian samples, as Canadian and non-Canadian participants show some differences in perception and positive attitude towards CAVs. The models reveal that the majority of the respondents prefer to get feedback and alerts from CAVs. Congenitally blind Canadians are less likely to trust CAVs, but non-Canadian congenital blinds tend to trust CAVs. The models also indicate that the respondents who experienced being near an accident with an electric vehicle (EV) are less likely to choose CAVs. Respondents who rely on mobile applications and technology-based devices for navigating purposes tend to trust CAVs. Blind people who rely on conventional navigation tools (e.g., white cane, guide dog, etc.) are less likely to be the users of CAVs. Gender effect is visible, as the female participants tend not to trust CAVs. In relation to policy recommendations, subsidies should be provided to various advocacy groups to offer orientation and mobility (O&M) training services, which are pivotal to educate how to use technology-based navigational services. Also, automobile manufacturers should be enforced to add acoustic vehicle alert systems (AVAS) to both EVs and CAVs.
Adipose Stem Cell–Derived Exosomes Decrease Fatty Infiltration and Enhance Rotator Cuff Healing in a Rabbit Model of Chronic Tears
Authors: Wang Chongyang , Hu Qingxiang , Song Wei , Yu Weilin , He Yaohua
Published: April 2020

Background:

Fatty infiltration and poor tendon-bone healing in chronic rotator cuff tears (RCTs) are associated with unsatisfactory prognosis. Adipose stem cell–derived exosomes (ASC-Exos), having multiple biological effects, can prevent muscle degeneration in acute RCTs. However, the effects of ASC-Exos on fatty infiltration and tendon-bone healing in chronic RCTs remain unknown.

Purpose:

To study the effects of ASC-Exos on fatty infiltration and tendon-bone healing in a chronic RCT rabbit model.

Study Design:

Controlled laboratory study.

Methods:

At week 0, we randomly allocated 35 rabbits to receive sham surgery (14 rabbits) or establish a bilateral RCT model (21 rabbits, detachment of the supraspinatus tendon). At week 6, a total of 7 rabbits received sham surgery, and 7 rabbits with RCT were sacrificed for fatty infiltration assay. The remaining 14 rabbits with bilateral RCTs were randomly assigned to a saline group (7 rabbits that received local saline injection and rotator cuff repair) or an ASC-Exos group (7 rabbits that received local ASC-Exos injection and rotator cuff repair). At week 18, all rabbits were sacrificed for histological examination and biomechanical testing.

Results:

At week 18, the ASC-Exos group showed significantly lower fatty infiltration (14.01% ± 2.85%) compared with the saline group (21.79% ± 3.07%) ( P < .001), and no statistical difference compared with the time of repair (10.88% ± 2.64%) ( P = .127). For tendon-bone healing, the ASC-Exos group showed a higher histological score and more newly regenerated fibrocartilage at the repair site than did the saline group. Regarding biomechanical testing, the ASC-Exos group showed significantly higher ultimate load to failure, stiffness, and stress than the saline group.

Conclusion:

Local injection of ASC-Exos in chronic RCTs at the time of repair could prevent the progress of fatty infiltration, promote tendon-bone healing, and improve biomechanical properties.

Clinical Relevance:

ASC-Exos injection may be used as a cell-free adjunctive therapy to inhibit fatty infiltration and improve rotator cuff healing in the repair of chronic RCTs.
Experimental and computational fluid dynamics modeling of a novel tray humidifier column in humidification dehumidification desalination; evaluation of hydrodynamic and heat transfer characteristics
Authors: Zarei Taleb , Jahromi Reza Hamidi , Karachi Arash Mohammadi
Published: April 2020

In this article, a novel tray humidifier column for humidification dehumidification desalination was proposed. The performance of the humidifier column has been investigated with experimental and computational fluid dynamics simulations. The hydrodynamics and heat transfer characteristics of this tray humidifier has been studied. A stainless steel sieve tray with a rectangular cross section with a dimension of 20 × 50 cm was used in the experimental study. In computational fluid dynamics modeling, a transient three-dimensional model has been developed based on the volume of fluid framework by using standard k-epsilon model. The effect of air and seawater flow rate and inlet seawater temperature on the exit air temperature has been investigated. The results show that the humidifier effectiveness of the tray humidifier column varies between 0.67 and 0.87 depending on operating conditions. Then, tray column can be used in humidification dehumidification desalination systems with advantages such as compact equipment, low-pressure drop, and handling solids or other sources of fouling.
Impact of a Palliative Care Education Module in Patients With Heart Failure
Authors: Thompson Shelley L. , Ward Cary , Galanos Anthony , Bowers Margaret
Published: April 2020

Background:

Heart failure (HF) impacts 6.2 million American adults. With no cure, therapies aim to prevent progression and manage symptoms. Inclusion of palliative care (PC) helps improve symptoms and quality of life. Heart failure guidelines recommend the inclusion of PC in HF therapy, but referrals are often delayed.

Objective:

Introduce PC to patients with HF and examine the impact on PC consults, readmission, mortality, and intensive care unit (ICU) transfers.

Methods:

Patients (n = 60) admitted with HF to an academic hospital were asked to view a PC educational module. A number of PC consults, re-admissions, mortality, and transfers to the ICU were compared among participants and those who declined.

Results:

Nine patients in the intervention group (n = 30) requested a PC consult ( P = .042) versus 2 in the usual care group (n = 30; P = .302). There was no statistically significant difference in readmissions, mortality, or ICU transfers between groups.

Conclusions:

Palliative care education increases the likelihood of PC utilization but in this short-term project was not found to statistically impact mortality, re-admissions, or transfers to higher levels of care.
Sovereign Bodies: Native Nations, Native American Women, and the Politics of 2018
Authors: Sanchez Gabriel R. , Foxworth Raymond , Evans Laura E.
Published: April 2020

What did Native American women and men voters think about Donald Trump on the eve of the 2018 election? This question has important implications for understanding the gendered political attitudes of peoples adversely targeted by Trump’s politics. To examine this issue, we analyze a path-breaking, nationally representative sample of six hundred Native American voters. We find that Native Americans’ attitudes about sexual harassment are central to their attitudes about politics and policy in the Trump era. This relationship suggests that Native American voters are an informed electorate influenced by the president’s words and actions. Our work demonstrates multiple ways that gender influenced Native American politics during an election where gender and racial identities were central. In so doing, our work illuminates how race, institutions, and vulnerability affect the political attitudes of Native American voters, one of the least studied groups in American politics.
International Society of Oncology Pharmacy Practitioners global position on the use of biosimilars in cancer treatment and supportive care
Authors: Frazer Morgan B , Bubalo Joseph , Patel Himanshu , Siderov Jim , Cubilla Milagros , De Lemos Mário , Dhillon Harbans , Harchowal Jatinder , Kuchonthara Nirachorn , Livinalli Annemeri , Macedo Rodrigo , Mwangi Winnie , Nomura Hisanaga , O’Connor Shaun , Patterson Maggie , Seadi Torriani Mayde , Yim Barbara , Chan Alexandre , Foreman Emma
Published: April 2020

With the development of innovative cancer treatments over recent decades, the cost of cancer care has risen exponentially, limiting patient access to patented originator biotherapeutics in many countries. The introduction of biosimilars to the market has created new opportunities as well the need for changes in practice within healthcare institutions. A ‘biosimilar’ is a biotherapeutic product which is highly similar in terms of quality, safety and efficacy to an already licensed originator product. Although biosimilars lack clinically meaningful differences in therapeutic activity as compared to the originator product, these complex biological molecules are not considered identical chemical copies, unlike generics, and minor differences in molecular structure and inactive compounds may exist. A thorough understanding of these differences and their clinical implications is necessary for optimising medicines-use practices involving biosimilars. This position statement, developed by the International Society of Oncology Pharmacy Practitioners Biosimilars Taskforce, aims to provide the global oncology pharmacy community with guidance to support decisions around biosimilar use. The 11 statements cover the regulation and evaluation of biosimilars, practical issues around local implementation, the education of healthcare staff and patients, and the requirement for ongoing pharmacovigilance and outcome monitoring.
Long-term response control in a patient with metastatic squamous cell lung cancer after treatment with nivolumab: a case report
Authors: Pampín-Sánchez R , Barbazán-Vázquez FJ , Fernández-González B , Rodríguez-de-Castro B , Aparicio-Carreño C , Sampedro-Gimeno T
Published: April 2020

Introduction

Nivolumab is a fully human programmed death control immune point 1 immune checkpoint inhibitor antibody which promotes antitumor immunity. Cutaneous toxicity associated with nivolumab, immune system related, could be linked to a more durable response in patients with squamous cell lung cancer.

Case report

We present the case of a 62-year-old male diagnosed with metastatic squamous cell lung cancer, who was treated with nivolumab after cytotoxic chemotherapy. After treatment discontinuation, due to grade 2 cutaneous toxicity, the patient is maintaining with durable partial response for more than one year with close follow-up.

Management and outcome

Cumulative doses of nivolumab could cause immunological toxicities that may prolong survival of these patients even after discontinuation of treatment.

Discussion

Nivolumab was approved by European Medicines Agency (EMA), as second-line therapeutic, for the treatment of squamous cell lung cancer, showing a median of 9.23 months of overall survival. The development of immune-related skin toxicities has been associated with greater clinical benefit in patients with lung cancer. When cutaneous toxicity forces to nivolumab suspension, in certain cases, the option of not starting again and closely following up the patient may appear reasonable, even though there are no survival data in this context. Suspension of treatment with close monitoring of these patients until progression may be an alternative, since immune-related skin toxicities could be related to a greater clinical benefit and a durable response to nivolumab.
Influence of apple peel powder addition on the physico-chemical characteristics and nutritional quality of bread wheat cookies
Authors: Nakov Gjore , Brandolini Andrea , Hidalgo Alyssa , Ivanova Nastia , Jukić Marko , Komlenić Daliborka Koceva , Lukinac Jasmina
Published: April 2020

Apple peel, a food industry by-product, is rich in fibre, polyphenols and minerals, and is a potentially attractive ingredient for bakery products. To evaluate the effect of wheat cookies enrichment with apple peel powder six types of cookies with increasing apple peel powder percentage (0%, 4%, 8%, 16%, 24% and 32%) were produced. The traits analysed were: pasting parameters; chemical properties (moisture, ash, lipid, protein, fibre and total polyphenols content); antioxidant capacity (2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power methods); physical attributes (width, thickness, volume and CIE lab colour); and sensory characteristics (external appearance, internal structure, texture, odour, taste and aroma). Statistical analysis included analysis of variance followed by Fisher's least significant difference test ( p < 0.05). The apple peel powder-enriched cookies had significantly higher moisture, ash, lipid, fibre, total polyphenols and antioxidant capacity than the control bread wheat cookies. The addition of apple peel powder did not modify the physical characteristics and improved the sensorial quality of the products. The addition of 24% apple peel powder gave the cookies with the best overall quality.
Parent–Child Interaction Therapy: Findings from an exploratory qualitative study with practitioners and foster parents
Authors: Blair Katelyn , Topitzes James , Winkler Erin N , McNeil Cheryl B
Published: April 2020

This exploratory study examines practitioners’ and foster parents’ perceptions on use of Parent–Child Interaction Therapy in child welfare. Focus groups were completed with Parent–Child Interaction Therapy practitioners and foster parents. Thematic analysis was employed, and four main themes were analyzed. First, practitioners and foster parents identified implementation barriers. Second, practitioners and foster parents identified factors that facilitate implementation. While practitioners perceived benefits from on-going consultation, foster parents favored treatment flexibility and a strong therapeutic alliance with practitioners. Third, practitioners and foster parents found that the integration of trauma principles into Parent–Child Interaction Therapy helped to meet the needs of the child welfare population. Finally, the translation of Parent–Child Interaction Therapy into child welfare may be facilitated by model adaptations, such as brief treatments, and integrating Parent–Child Interaction Therapy into pre-service foster parent trainings. Findings are discussed within the context of the relevant literature, and recommendations for future areas of study are proposed.
Road lighting and distraction whilst driving: Establishing the significant types of distraction
Authors: Robbins CJ , Fotios S
Published: April 2020

There is a body of research showing how changes in lighting conditions affect hazard detection in the context of driving after dark. There is a separate body of research showing that driving is impaired by distraction. The two have yet to be integrated: this is critical for lighting design recommendations because giving consideration to distraction may affect the optimal conditions established in lighting studies. A first step in that process is establishing the critical type(s) of distraction that might then be simulated in lighting research. This paper reviews evidence for the prevalence of driving distractions as recorded by two methods: interviews with drivers following collision and observation of drivers on real roads. These data suggest that auditory distractions such as conversation with passengers and listening to music are prevalent distractions, and are therefore appropriate distractions to incorporate in further research of lighting and hazard detection experiments.
Hydrogen sulfide attenuates diabetic neuropathic pain through NO/cGMP/PKG pathway and μ-opioid receptor
Authors: Li Hao , Liu Shulin , Wang Zheng , Zhang Yonglai , Wang Kaiguo
Published: April 2020

Diabetic neuropathic pain is a frequent complication of diabetic neuropathy. The specific manifestations of diabetic neuropathic pain include spontaneous pain and hyperalgesia, which seriously affect the quality of life of patients. Previous publications have shown that H2S has both pro-nociceptive and anti-nociceptive effects. This present investigation aimed to examine the anti-nociceptive effect of H2S on diabetic neuropathic pain. We established a diabetic neuropathic pain animal model with high-glucose, high-fat diet, and STZ, then treated rats with different concentrations of H2S and inhibitors of NOS, sGC, PKG, and opioid receptors. The mechanical allodynia and thermal hyperalgesia of rats were measured to assess the anti-nociceptive effects of H2S. The mRNA and protein expression of NOS and PKG1 were measured to explore their roles in the anti-nociceptive action of H2S. The results revealed that inhalation of H2S gas had anti-nociceptive effect in diabetic neuropathic pain model rats without affecting the blood glucose level and body mass. It increased the mRNA and protein level of nNOS, and the inhibitor of nNOS, 7-NI, abolished the anti-nociceptive effect of H2S. Furthermore, inhibitors of sGC and PKG could also abolish the anti-nociceptive effect of H2S. The expression of PKG1 was found to be increased by H2S, which was reversed by the inhibitors of nNOS, sGC, and PKG. Finally, CTOP, a μ-opioid receptor antagonist, abolished the anti-nociceptive effect of H2S, indicating that the μ-opioid receptor plays a role in the anti-nociceptive effect of H2S. In conclusion, the findings of this investigation suggest that hydrogen sulfide may attenuate the diabetic neuropathic pain through NO/cGMP/PKG pathway and μ-opioid receptor.

Impact statement

There are currently approximately 425 million diabetic patients worldwide, of which approximately 90% of patients with diabetes suffer from neuropathy. Diabetic neuropathic pain (DNP) is a common complication of diabetic neuropathy. Nearly half of the patients hospitalized with diabetes have pain symptoms or symptoms related to neurological injury, and the incidence increases with age and diabetic duration. Anti-DNP analgesics have either limited therapeutic effects or serious side effects or lack of clinical trials, which has limited their application. Physiopathological mechanisms and treatment of DNP remain a significant challenge. The present confirmed that inhalation of H2S may attenuate the diabetic neuropathic pain through NO/cGMP/PKG pathway and μ-opioid receptor. It provides us the animal study foundation for the application of H2S on the treatment of DNP and clarifies some target molecules in the pain modulation of DNP.
Hybrid Repair of Distal Aortic Arch Dissection Aneurysm With Dissected Kommerell Diverticulum
Authors: Tigkiropoulos Konstantinos , Kousidis Panagiotis , Lazaridis Ioannis , Saratzis Nikolaos
Published: April 2020

Aberrant right subclavian artery (ARSA) with associated Kommerell diverticulum (KD) is a rare congenital aortic arch anomaly. Patients with KD have a high risk of rupture, dissection, compression of adjacent structures, as well as distal embolization symptoms. Several treatment options have been proposed (surgical, hybrid, endovascular), however, a consensus regarding optimal surgical management has not been established yet. We present a successful single-stage hybrid repair of distal aortic arch dissection aneurysm with dissecting KD and ARSA with debranching of innominate and left common carotid artery, bilateral carotid-subclavian bypass, and stent grafting.
Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes
Authors: Hodge Greg , Tran Hai B. , Reynolds Paul N. , Jersmann Hubertus , Hodge Sandra
Published: April 2020

Background:

The class III NAD-dependent histone deacetylase (HDAC) sirtuin 1 (SIRT1) is an important regulator of senescence, aging, and inflammation. SIRT1de-acetylates chromatin histones, thereby silencing inflammatory gene transcription. We have reported increased steroid-resistant senescent pro-inflammatory CD28nullCD8+ T cells in patients with chronic obstructive pulmonary disease (COPD). We hypothesized that SIRT1 is reduced in these cells in COPD, and that treatment with SIRT1 activators (resveratrol, curcumin) and agents preventing NAD depletion (theophylline) would upregulate SIRT1 and reduce pro-inflammatory cytokine expression in these steroid-resistant cells.

Methods:

Blood was collected from n = 10 COPD and n = 10 aged-matched controls. Expression of CD28, SIRT1, and pro-inflammatory cytokines was determined in CD8+ and CD8– T and natural killer T (NKT)-like cells cultured in the presence of ±1 µM prednisolone, ±5 mg/L theophylline, ±1 µM curcumin, ±25 µM resveratrol, using flow cytometry and immunofluorescence.

Results:

There was an increase in the percentage of CD28nullCD8+ T and NKT-like cells in COPD patients compared with controls. Decreased SIRT1 expression was identified in CD28nullCD8+T and NKT-like cells compared with CD28+ counterparts from both patients and controls (e.g. CD28null 11 ± 3% versus CD28+ 57 ± 9%). Loss of SIRT1 was associated with increased production of IFNγ and TNFα, steroid resistance, and disease severity. SIRT1 expression was upregulated in the presence of all drugs and was associated with a decrease in steroid resistance and IFNγ and TNFα production by CD28nullCD8+T and NKT-like cells. The presence of the SIRT1 inhibitor, EX-527 negated [by 92 ± 12% (median ± SEM)] the effect of the SIRT1 activator SRT720 on the percentage of CD8+ T cells producing IFNγ and TNFα.

Conclusions:

Steroid resistance in pro-inflammatory CD28nullCD8+ T and NKT-like cells is associated with decreased SIRT1 expression. Treatment with prednisolone, in combination with theophylline, curcumin or resveratrol increases SIRT1 expression, restores steroid sensitivity, and inhibits pro-inflammatory cytokine production from these cells and may reduce systemic inflammation in COPD. The reviews of this paper are available via the supplemental material section.
Potential neuro-immune therapeutic targets in irritable bowel syndrome
Authors: Casado-Bedmar Maite , Keita Åsa V.
Published: April 2020

Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by recurring abdominal pain and disturbed bowel habits. The aetiology of IBS is unknown but there is evidence that genetic, environmental and immunological factors together contribute to the development of the disease. Current treatment of IBS includes lifestyle and dietary interventions, laxatives or antimotility drugs, probiotics, antispasmodics and antidepressant medication. The gut–brain axis comprises the central nervous system, the hypothalamic pituitary axis, the autonomic nervous system and the enteric nervous system. Within the intestinal mucosa there are close connections between immune cells and nerve fibres of the enteric nervous system, and signalling between, for example, mast cells and nerves has shown to be of great importance during GI disorders such as IBS. Communication between the gut and the brain is most importantly routed via the vagus nerve, where signals are transmitted by neuropeptides. It is evident that IBS is a disease of a gut–brain axis dysregulation, involving altered signalling between immune cells and neurotransmitters. In this review, we analyse the most novel and distinct neuro-immune interactions within the IBS mucosa in association with already existing and potential therapeutic targets.
Sternoclavicular joint injections and their predictive value for the outcome of surgery
Authors: Urbanschitz Lukas , Kriechling Philipp , Fritz Benjamin , Meyer Dominik C , Wieser Karl
Published: April 2020

Background

Sternoclavicular joint injections are one of the first-line treatment options for painful non-infectious pathologies of the sternoclavicular joint; however, their long-term effects and predictive value in decision-making for surgery are yet to be defined.

Methods

27/32 Patients who received in total 36 computed tomography-guided sternoclavicular joint injections in 2012–2017 replied the questionnaire with a mean follow-up of 38 months after the first sternoclavicular joint injection. Of those patients, seven underwent subsequent surgery. We evaluated pain response after sternoclavicular joint injection and American Shoulder and Elbow Surgeons-score at later follow-up.

Results

Directly after sternoclavicular joint injection, pain decreased from Visual Analog Scale 5.3 ± 2.4 to 3.8 ± 3 (p = 0.001). In the seven patients who underwent surgery for degenerative changes, definitive outcome correlated with pain relief after the last infiltration (r = 0.86, p = 0.012). Also, the final American Shoulder and Elbow Surgeons-score was lower in patients with multiple injections compared to those who were satisfied after the first injection (p = 0.019).

Discussion

Sternoclavicular injections are a useful tool in the context of degenerative sternoclavicular joint disorders as the amount of pain reduction is, in case the short-term effect is not long-lasting, at least a strong indicator for the future success of operative treatment.
Nutraceutical Improves Glycemic Control, Insulin Sensitivity, and Oxidative Stress in Hyperglycemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Authors: Bumrungpert Akkarach , Pavadhgul Patcharanee , Chongsuwat Rewadee , Komindr Surat
Published: April 2020

The aim of this research was to investigate the effects of nutraceuticals including bitter melon, fenugreek, cinnamon, alpha-lipoic acid, zinc, biotin, chromium, and cholecalciferol on glycemic control, insulin sensitivity, lipid profiles, oxidative stress, and inflammatory markers in hyperglycemia. The study design was a randomized, double-blind, placebo-controlled trial. Subjects with hyperglycemia were randomly divided into 2 groups. The treatment group ( n = 52) was given a nutraceutical and the control group ( n = 50) was provided with a placebo for 12 weeks. Fasting blood glucose (FBG), hemoglobin A1c (HbA1C), homeostatic model assessment of insulin resistance (HOMA-IR), lipid profiles, biomarkers of oxidative stress, and inflammation were assessed before and after the intervention at 6 weeks and 12 weeks. Nutraceutical supplementation demonstrated a statistically significant decrease in FBG (13.4% and 18.9%), HbA1C (6.5% and 11.3%), and HOMA-IR (28.9% and 35.2%) compared with the placebo. Moreover, low-density lipoprotein-cholesterol (LDL-C) level was significantly reduced in the nutraceutical group (7.1% and 9.3%). Furthermore, the nutraceutical significantly decreased oxidative stress markers, oxidized LDL-C (14.8% and 18.9%) and malondialdehyde (16.6% and 26.2%) compared with the placebo. In conclusion, this nutraceutical can improve glycemic control, insulin resistance, lipid profiles, and oxidative stress markers in hyperglycemic subjects. Therefore, it has the potential to decrease cardiovascular disease risk factors. Clinical trial registration: TCTR20180907001, www.clinicaltrials.in.th.
Nasal Function Changes at High Altitude
Authors: Ottaviano Giancarlo , Nardello Ennio , Pendolino Alfonso Luca , Pozza Martino Dalla , Russo Massimiliano , Savietto Enrico , Andrews Peter J. , Ermolao Andrea
Published: April 2020

Background

An ever-increasing number of people are involved in sport activities at high altitude.

Objective

This study aimed to evaluate the pulmonary and nasal functions, including nasal cytology, in healthy volunteers moving for 1 week from an altitude of 2000 m to another of 3400 m.

Methods

Peak nasal inspiratory flow (PNIF), pulmonary function, including peak expiratory flow (PEF), mucociliary transport time (MCTt), nasal cytology, and oxygen saturation (O2 sat) were studied in 5 different occasions—T1: at base camp (2000 m); T2: at the mountain refuge (3400 m); T3: after 7 days at 3400 m; T4: after the return at the base camp (2000 m); and T5: at the base camp (2000 m) after 15 days.

Results

With respect to T1, PEF values decreased at T2 ( P = .004), T3 ( P = .004), T4 ( P = .000), and T5 ( P = .001). Forced expiratory volume in the first second and forced vital capacity did not differ among the 5 different times of measurements. In regard to T1, PNIF values increased at T2 ( P = .003) and T3 ( P = .001). MCTt and O2 sat showed similar but opposite changes with MCTt increased at T2 and T3 in respect to T1 ( P = .000 for both), while O2 sat decreased at T2 and T3 in respect to T1 ( P = .000 for both). At nasal cytology, the number of neutrophils increased at T2 in respect to T1 ( P = .008). At multivariate analysis, PNIF changed with altitude from T1 to T4 even accounting for the effect of all the other variables (T1 vs T2 PNIF, P = .009; T1 vs T3 PNIF, P = .007; T1 vs T4 PNIF, P = .021).

Conclusions

Although the study has some limitations, being conducted on a small cohort and at no controlled environmental conditions, data seem to support the utility of MCTt for studying nasal mucosa damage induced by high altitude. Nasal cytology seems to be able to identify the inflammation of the nasal mucosa exposed to hypoxia. Further investigations on larger series and possibly conducted in hypobaric chamber at controlled standardized conditions are necessary in order to confirm these results and, most importantly, the improvement of PNIF at high altitude.
Is Low Power Associated With Submission During Marital Conflict? Moderating Roles of Gender and Traditional Gender Role Beliefs
Authors: Pietromonaco Paula R. , Overall Nickola C. , Beck Lindsey A. , Powers Sally I.
Published: April 2020

Lower power during marital interactions predicts greater aggression by men, but no research has identified women’s response to lower power. We tested whether women who experienced lower situational power during conflict exhibited greater submission, especially if they held traditional gender role beliefs and thus accepted structural gender differences in power. Newlywed couples (Time 1, N = 204 couples) completed questionnaires and discussed an area of conflict 3 times over 3 years. Individuals who perceived lower power during couples’ discussions evidenced greater submission, but this effect was more pronounced for wives, especially wives who held traditional gender role beliefs. Among those with traditional gender role beliefs, greater submission together with lower power predicted lower marital adjustment over time. These results highlight that the low power–submission link, and associated implications for marital adjustment, need to be evaluated in the context of power-relevant situations, gender, and broader power-related beliefs about gender roles.
New advances in mechanomyography sensor technology and signal processing: Validity and intrarater reliability of recordings from muscle
Authors: Meagher Claire , Franco Enrico , Turk Ruth , Wilson Samuel , Steadman Nathan , McNicholas Lauren , Vaidyanathan Ravi , Burridge Jane , Stokes Maria
Published: April 2020

Introduction

The Mechanical Muscle Activity with Real-time Kinematics project aims to develop a device incorporating wearable sensors for arm rehabilitation following stroke. These will record kinematic activity using inertial measurement units and mechanical muscle activity. The gold standard for measuring muscle activity is electromyography; however, mechanomyography offers an appropriate alterative for our home-based rehabilitation device. We have patent filed a new laboratory-tested device that combines an inertial measurement unit with mechanomyography. We report on the validity and reliability of the mechanomyography against electromyography sensors.

Methods

In 18 healthy adults (27–82 years), mechanomyography and electromyography recordings were taken from the forearm flexor and extensor muscles during voluntary contractions. Isometric contractions were performed at different percentages of maximal force to examine the validity of mechanomyography. Root-mean-square of mechanomyography and electromyography was measured during 1 s epocs of isometric flexion and extension. Dynamic contractions were recorded during a tracking task on two days, one week apart, to examine reliability of muscle onset timing.

Results

Reliability of mechanomyography onset was high (intraclass correlation coefficient = 0.78) and was comparable with electromyography (intraclass correlation coefficient = 0.79). The correlation between force and mechanomyography was high (R2 = 0.94).

Conclusion

The mechanomyography device records valid and reliable signals of mechanical muscle activity on different days.
Predictors of College Success Outcomes in Emerging Adults: The Role of High School Dual Enrollment Courses
Authors: Kremer Kristen P.
Published: April 2020

The current study seeks to identify the role of dual enrollment participation on college outcomes among emerging adults. Data were used from the nationally representative High School Longitudinal Study of 2009. Propensity score matching matched students who did and did not take dual enrollment courses in high school. Logistic regression analyses predicted college success from dual enrollment participation. Youth who took dual enrollment courses had an increased odds of attending college ( OR = 1.40, SE = .05), persisting in college ( OR = 1.40, SE = .06), and taking full-time course loads ( OR = 1.32, SE = .06). They were less likely to attend a 2-year institution ( OR = 0.75, SE = .05) and take remedial coursework ( OR = 0.70, SE = .05). Interactions by race and socioeconomic status found dual enrollment participation to be more strongly associated with remedial coursework for students from lower socioeconomic status households ( OR = 0.83, SE = .08). Further research should explore policies surrounding access to dual enrollment courses and strategies for increasing participation in dual enrollment courses.
Hidden Invalidity Among 15 Commonly Used Measures in Social and Personality Psychology
Authors: Hussey Ian , Hughes Sean
Published: April 2020

It has recently been demonstrated that metrics of structural validity are severely underreported in social and personality psychology. We comprehensively assessed structural validity in a uniquely large and varied data set ( N = 144,496 experimental sessions) to investigate the psychometric properties of some of the most widely used self-report measures ( k = 15 questionnaires, 26 scales) in social and personality psychology. When the scales were assessed using the modal practice of considering only internal consistency, 88% of them appeared to possess good validity. Yet when validity was assessed comprehensively (via internal consistency, immediate and delayed test-retest reliability, factor structure, and measurement invariance for age and gender groups), only 4% demonstrated good validity. Furthermore, the less commonly a test was reported in the literature, the more likely the scales were to fail that test (e.g., scales failed measurement invariance much more often than internal consistency). This suggests that the pattern of underreporting in the field may represent widespread hidden invalidity of the measures used and may therefore pose a threat to many research findings. We highlight the degrees of freedom afforded to researchers in the assessment and reporting of structural validity and introduce the concept of validity hacking ( v-hacking), similar to the better-known concept of p-hacking. We argue that the practice of v-hacking should be acknowledged and addressed.
People living in nursing care facilities who are ambulant and fracture their hips: description of usual care and an alternative rehabilitation pathway
Authors: Killington Maggie , Davies Owen , Crotty Maria , Crane Rhiannon , Pratt Naomi , Mills Kylie , McInnes Arabella , Kurrle Susan , Cameron Ian D.
Published: April 2020

Background

Little is known about treatment provided to people living in nursing care facilities (NCFs) after hospital admission for hip fracture. In addition, there are no clinical guidelines for rehabilitation and recovery following hip fracture for nursing home residents.

Methods

As part of a randomised trial (SACRED trial), which investigated the efficacy of a four week in-reach rehabilitation program, data were collected which described routine care for 240 people living in 76 nursing care facilities in South Australia who fractured their hips. The in-reach rehabilitation provided to 119 intervention participants is described, including intensity, type and methods used to encourage participation in rehabilitation. Adverse events that occurred, in particular falls, are also reported.

Results

NCF records indicated that, over the four weeks following discharge from hospital after hip fracture, 76% of patients receiving usual care had a consultation with their general practitioner. Physiotherapy was provided to 79% of patients in usual care (median of 1.96 h over the 4 weeks, which is less than 30 min each week of physiotherapy). In-reach rehabilitation was provided by the hospital team for 13 h over the 4 weeks with almost full attendance at physiotherapy sessions (median of 1 missed session, range 0–7 with a median of 14 physiotherapy sessions attended by participants, range 1–18). Experienced therapists provided a flexible approach to the rehabilitation to account for patients’ dementia and associated neuropsychiatric symptoms while providing dietetic support, mobility training and education to nursing home staff. The number of falls experienced by those in the intervention group was higher compared to those in usual care (Relative Risk 1.38 (95%CI 1.04–1.84, p = 0.03).

Conclusions

Rehabilitation can be provided to people living in NCFs following hip fracture, even when they have moderate to severe dementia but the model needs to be flexible. Provision of rehabilitation may increase the rate of falls in this population. Further studies are required to establish the feasibility of the intervention in other long term care settings. (327 words).

Trial registration

ACTRN12612000112864 registered on the Australian and New Zealand Clinical Trials Registry (ANZCTR).