bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistem Deteksi Dini Bencana Banjir Menggunakan Modul 433MHz Berbasis Arduino
Authors: Arifin M. Zainal
Published: August 2020

Banjir adalah bencanan alam yang sulit di deteksi kapan akan datang terutama di musim hujan. Akibatnya banyak masyarakat yang kehilangan harta benda bahkan terkadang sampai menimbulkan korban jiwa akibat bencana banjir. Untuk itu, estimasi level ketinggian air penting untuk menentukan bahaya mendasar dalam resiko datangnya banjir. Objek pengukuran yang digunakan dalam penelitian ini yaitu Tinggi Muka Air (TMA) dengan menggunakan teknik pesan singkat  yang bisa dikirim melalui gelombang radio dan sensor ketinggian air sungai sebagai sensor yang mengambil nilai ketinggian air sungai itu sendiri, sehingga tidak membutuhkan sinyal dan jaringan internet serta tidak membutuhkan pulsa untuk penggunaannya. hasil akhir dari penelitian ini adalah informasi ketinggian air yaitu status normal, siaga I, siaga II, siaga III atau siaga IV.
Pembangunan Aplikasi Mobile Hybrid Pada M-Voting Pemilu Raya Universitas Muhammadiyah Malang
Authors: Santoso Hartanto , Suharso Wildan , Hariyady Hariyady
Published: August 2020

Voting merupakan pemilihan suara terbanyak yang bertujuan untuk mencari suatu kesepakatan bersama terhadap sesuatu yang penting. Pada penelitian ini bertujuan membangun frontend aplikasi m-voting untuk pemilu raya di Universitas Muhammadiyah Malang. Penelitian ini menggunakan metode User Centered Design (UCD), metode ini berfokus pada pengguna sebagai pusat dalam pengembagan aplikasi. Pada pembangunan aplikasi ini menggunakan framework flutter. Flutter merupakan framework yang dibuat google menggunakan bahasa dart. Flutter bersifat cross platform, dimana pengembagan menggunakan framework ini dapat membuat satu aplikasi yang dapat berjalan di dua sistem operasi baik iOs dan android. Sedangkan untuk pengujian pada pembangunan frontend aplikasi M-voting ini menggunakan System Usability Scale (SUS). Skor yang didapatkan setelah pengujian sebesar 71,61 yang berdasarkan interpretasi menggunakan rating SUS score berada pada tingkat ‘Good’.
Komparasi Algoritma Machine Learning dan Deep Learning untuk Named Entity Recognition : Studi Kasus Data Kebencanaan
Authors: Giarsyani Nuli
Published: August 2020

Indonesia merupakan negara yang rawan akan bencana. Beberapa bencana alam yang sering tercatat sering terjadi di Indonesia adalah mulai dari gempa, tsunami, banjir, tanah longsor, gunung meletus dan masih banyak lagi yang lainnya. Adanya kejadian ini mendorong pengguna Twitter atau lembaga penanggulangan kebencanaan untuk mengunggah informasi tentang kondisi bencana dari tempat terjadinya bencana. Namun tidak semua tweet yang diunggah tersebut memuat informasi tentang bencana. Untuk dapat memanfaatkan informasi spesifik berkaitan dengan jenis jenis bencana, lokasi bencana, dan waktu kejadian, maka seseorang harus membaca secara keseluruhan isi tweet tersebut. Apabila jumlahnya banyak, maka membutuhkan waktu yang cukup lama untuk
mendapatkan informasi bencana pada tweet tersebut. Oleh sebab itu, dibutuhkan Named Entity Recognition (NER) yang dapat digunakan untuk mendapatkan informasi penting secara otomatis dalam waktu yang singkat. Penelitian ini bertujuan untuk melakukan NER pada data tweet dan melakukan analisa terdahap hasil dari dua pendekatan yaitu Machine Learning dan Deep Learning. Secara spesifik, kami membandingkan akurasi beberapa metode dari Machine Learning dan Deep Learning dan melakukan klasifikasi, dan menemukan bahwa pendekatan Deep Learning lebih unggul daripada pendekatan Machine Learning.
Optimasi Asupan GGL Ideal Pada Usia Produktif Dengan Algoritma Genetika
Authors: Sinaga Anita Sindar RM
Published: August 2020

Financial security encourages fast food eating habits, the characteristics of problems that require solving genetic algorithms that have multi-objective and multi-criteria. Based on the mathematical model built, an analysis is performed to find the best (optimal) solution. Optimization is an effort or activity to get the best results with the requirements given. Genetic Algorithm as a branch of Evolution Algorithm is an adaptive method commonly used to solve a value search in an optimization problem. To check the results of the optimization we need a fitness function, which signifies a coded description of the solution. During the process, the parent must be used for reproduction, crossing and mutation to obtain new offspring. Determination of the composition of the ideal GGL for productive age must meet the minimum limits for each component of nutrition. The higher the Fitness value the better the chromosomes become a candidate solution. Offspring results generated from the results of the reproduction process are crossever and mutation. The selection process is carried out to obtain the best chromosomes that will be made into the next generation's population. The best chromosomes  offSpring 10 Fitness 12737.34.
Pengenalan Batik Indonesia Menggunakan Ciri Warna dan Tekstur
Authors: Rachmawati Ema , Anjani Maula Ilma Ahgnia Dwi , Sthevanie Febryanti
Published: August 2020

Upaya pelestarian budaya bangsa melalui pengenalan batik merupakan hal yang harus selalu ditingkatkan. Terlebih dengan diakuinya budaya batik Indonesia oleh UNESCO sebagai bagian dari warisan budaya tak berwujud (intangible). Hal inilah yang mendasari dilakukannya sejumlah penelitian terkait pengenalan batik. Hasil kinerja yang sangat baik telah dicapai oleh berbagai sistem pengenalan batik. Namun, berbagai penelitian yang dilakukan tersebut masih terbatas pada jumlah motif batik yang sedikit. Oleh karena itu, pada penelitian ini dibangun sistem pengenalan batik dengan menggunakan 114 motif batik dari 14 daerah di propinsi Jawa Barat. Ciri gabungan dibangun dengan mengkombinasikan ciri tekstur dan warna. Ciri tekstur didapatkan dari Gray Level Co-occurrence Matrix (GLCM) sedangkan ciri warna didapatkan dari Color Difference Histogram (CDH). Penulis juga menambahkan variasi dalam dataset yang berupa rotate dan flip untuk memperbesar variasi intra-class. Hasil utama dari kinerja sistem yang dibuat adalah akurasi sebesar 99,128 % dan F1-Score sebesar 98,9999% pada pengenalan batik berdasarkan daerah, sedangkan pada pengenalan batik berdasarkan motif didapatkan akurasi sebesar 98,2456% dan F1-Score  sebesar 98,3208%.  
О логиках эмпирических модальностей
Authors: Финн Виктор Константинович
Published: August 2020

В статье рассматривается класс ERA-логик с эмпирическими модальностями $\square$ (необходимость) и $\lozenge$ (возможность), которые характеризуют, соответственно, высказывания, представляющие эмпирические законы и эмпирические тенденции, т.е. эмпирические закономерности. Эмпирические закономерности являются результатом ДСМ-рассуждений, которые образованы взаимодействием правил индуктивного вывода и правил вывода по аналогии, а также процедурами абдуктивного принятия гипотез.

Рассматриваемые ERA-логики являются пропозициональной имитацией ДСМ-рассуждений, применимых к последовательностям расширяемых баз фактов интеллектуальных систем. Характерной особенностью ERA-логик является применение двух концепций истины – когерентной и корреспондентной. Применение когерентной концепции истины обусловлено порождением гипотез посредством правил индуктивного вывода и вывода по аналогии. Применение же корреспондентной концепции истины обусловлено применением абдуктивного вывода, принятие результатов которого использует верификацию гипотез о предсказаниях. С этой целью ERA-логики применяют оператор Т: «истинно, что…». В заключении статьи обсуждаются нефинитные расширения ERA-логик, а также их отличия как логик эмпирических модальностей от логики М логических модальностей Г.Х. фон Вригта.
New semantics for urn logics: taming the enduring scandal of deduction
Authors: Mendonça Bruno R. , Carnielli Walter A.
Published: August 2020

The traditional theory of semantic information, originally proposed by [Bar-Hillel, Carnap, 1953], provides a versatile and pretty plausible conception of what kind of thing semantic information is. It embodies, however, the so-called “scandal of deduction”, a thesis according to which logical truths are informationally empty. The scandal of deduction is prob- lematic because it contradicts the fact that ordinary reasoners often do not know whether or not a given sentence is a logical truth. Hence, it is plausible to say, at least from the epistemological standpoint of those reasoners, that such logical sentences are really inform- ative. In order to improve over traditional theory, we can replace its classical metatheory by the so-called urn logics, non-standard systems of logic (described in detail below) that better describe the epistemological standpoint of ordinary reasoners. Notwithstanding, the applic- ation of such systems to the problem of semantic information faces some challenges: first, we must define truth-conditional semantics for these systems. Secondly, we need to precisely distinguish two systems of urn logic, namely, perfect and imperfect urn logics. Finally, we need to prove characterization theorems for both systems of urn logic. In this paper we offer original (and hopefully, elegant) solutions for all such problems.
Resposta fisiológica do algodão colorido em estresse salino
Authors: Pereira Elizandra Ribeiro de Lima , Medeiros Marcos Barros de , Suassuna Janivan Fernandes , Morais Virgínia Maria Magliano , Fernandes Hélder Formiga , Lima Andréia Santos de , Costa Natanaelma Silva da , Fernandes Pedro Dantas
Published: August 2020

O estresse salino representa um dos mais sérios fatores que limitam o crescimento e a produção das culturas. Objetivou-se nesta pesquisa conhecer qual a conduta de resposta fisiológica de dez genótipos de algodão colorido, submetidos a três diferentes condições de estresse salino em ambiente telado. O experimento foi conduzido no Município de Campina Grande-PB. O delineamento experimental foi bloco casualizado com 10 tratamentos, três condições de salinidade e três repetições. Cada parcela foi constituída de 10 tubetes de 288 mL contendo uma planta cada utilizando NaCl, CaCl2, MgCl2. Foram avaliadas a condutância estomática (gs) (mol m-² s-¹), taxa de assimilação de CO2 (A) (µmol m-² s-¹), transpiração (E) (mmol m-² s-¹) e concentração interna de CO2 (Ci) (µmol mol-¹). Por meio da relação entre A/Ci obteve-se a eficiência instantânea de carboxilação, e entre a taxa de assimilação de CO2 (A) a transpiração. Conclui-se que o estresse salino causa alterações fisiológica pela perda da concentração interna e condutância estomática dos genótipos do algodoeiro colorido estudado. A variedade BRS Safira é mais sensível ao estresse salino. Duas variedades e quatro linhagens mostraram ser mais tolerantes ao estresse salino.
Qualidade da composição do extrato de própolis verde sob influência do Bioma Caatinga
Authors: Lima Maria Verônica Lins , Medeiros Marcos Barros de , Silva Osvaldo Soares da , Silva Rosilene Agra da , Maracajá Patrício Borges , Lima Lígia Maria Ribeiro , Morais Virgínia Maria Magliano , Fernandes Hélder Formiga
Published: August 2020

A própolis é um produto apícola de constituição química complexa produzida pelas abelhas. Elas colhem as gotas e partículas expiradas dos brotos e botões florais que se unem a outras substâncias e secreções, e transformam-se em uma rica resina com várias finalidades de uso. O objetivo geral desta pesquisa foi avaliar a influência do armazenamento a frio da própolis verde colhida na Região Curimataú Oriental, no semiárido brasileiro do Estado da Paraíba, sob temperatura controlada. Foram analisadas 20 amostras de própolis; divididas em dois grupos A e B com 10 amostras cada um. As amostras foram submetidas ao armazenamento a frio a 10 °C, por um período de 12 meses; as amostras do grupo B foram colhidas e imediatamente submetidas às análises, em temperatura ambiente. Foi possível concluir que as características físicas e químicas para os extratos das própolis, verde, permaneceu com suas características preservadas mantendo excelente qualidade em função do armazenamento, por um período de 12 meses, conclui-se que a própolis verde da Região do Curimataú Paraibano tem uma qualidade excepcional.
Trilhas interpretativas utilizadas como recurso pedagógico: formação e informação no ensino básico
Authors: Santos Suellen da Silva , Pedrosa Kamila Marques , Andrade Edardna Suzana , Silva Jackson dos Santos , Rodrigues Ewerton Freire , Xavier Wilson José Félix
Published: August 2020

Ao longo dos anos tem se intensificado a busca por novos recursos pedagógicos e metodológicos que possam ser aplicados para o processo de ensino-aprendizagem. Atividades práticas em trilhas interpretativas podem ser uma forma de auxiliar nas atividades didáticas desenvolvidas pelos profissionais da educação. Neste contexto, o estudo buscou compreender a importância da trilha interpretativa como possível recurso didático voltado para todas as disciplinas que compõe a educação básica. O público participante da pesquisa foram oito professores lotados em três instituições públicas do Município de Areia, Paraíba (Nordeste do Brasil) e uma discente do curso de geografia. O estudo aconteceu em duas etapas, primeiramente em sala de aula para contextualização da temática e o segundo momento na trilha interpretativa localizada no Parque Estadual Mata do Pau Ferro. Foram realizadas análises do tipo descritiva e participante, a partir de uma abordagem qualitativa uma vez que as informações coletadas e tabuladas se deram através de questionários estruturados, observações e conversas. Notou-se que os docentes ainda não se apropriaram do espaço sugerido para incorporação do recurso, porém mostraram-se interessados em aderi-lo tanto para fins de educação ambiental quanto para colocar em prática os conteúdos explanados em suas aulas, por mais que não atuem em áreas das ciências ambientais. Para isso é necessário vinculo de maior intensidade entre as instituições de ensino superior - ensino básico - comunidade, a última por atuar como agente promissora de conhecimento local, pois as pessoas presentes nas áreas do entorno da unidade de conservação onde está presente a sugerida trilha participam efetivamente de sua gestão.
The Instrument of Teaching Metacognition in Reading Classrooms: The ITMR
Authors: OZTURK Nesrin
Published: August 2020

Limited influence of metacognition research in mainstream classrooms may stem from a lack of comprehensive pedagogy and/or inconsistent criteria assessing metacognition instruction. For this problem, an instrument designed for metacognition instruction in reading classes was examined. After a systematic and analytic review of broad literature, scale validation procedures were followed. Items that represent observable and measurable teacher-behavior promoting students’ metacognition were generated. Next, QUAID examination, expert-, cognitive-, and focus-group interviews were conducted. Data collected from reading teachers via a computer-assisted survey method were analyzed by exploratory factor analysis, Welch’s, and Spearman’s tests. Findings confirmed that the ITMR had a unidimensional model accounting for 60% of metacognition instruction (α.97). There were no mean differences in metacognition instruction at any elementary grades. The items on the ITMR were also strongly and positively correlated. Thereby, the ITMR can be used to assist and identify classroom metacognition instruction in reading classrooms.
Antioxidant and anti-diabetic activity of pomegranate (Punica granatum L.) leaves extracts
Authors: Cheurfa Mohammed , Achouche Mohamed , Azouzi Ahmed , Abdalbasit Mariod A.
Published: August 2020

Introduction. This study aimed to evaluate the antioxidant and anti-diabetic activity of aqueous and hydroalcoholic extracts of pomegranate (Punica granatum L.) leaves in vitro, as well as to determine the content of polyphenols, flavonoids, and flavonols.

Study objects and methods. The antioxidant activity was determined by the DPPH test using the free radical 1,1-diphenyl-2-picrylhydrazyle and the FRAP method, as well as by measuring total antioxidant capacity and the hydrogen peroxide scavenging activity.

Results and discussion. The content of total polyphenols varied between 4.43 ± 0.3 and 12.66 ± 1.6 mg EAG/g. The highest content of flavonoids was observed in the hydroalcoholic extract of P. granatum leaves (P < 0.05). The flavonol contents in the hydroalcoholic and aqueous extracts were 7.68 ± 0.6 and 9.20 ± 2.8 mg EQ/g, respectively. The IC50 of the antioxidant potential of the hydroalcoholic and aqueous extracts was 32.4 ± 1.109 and 35.12 ± 4.107 mg/mL, respectively. According to the DPPH test, the aqueous extract was the least active (IC50 = 14.15 ± 1.513 mg/mL). The highest percentage of hydrogen peroxide trapping was found in the aqueous extract

(45.97 ± 6.608 %). The inhibition of α-amylase showed an IC50 of between 9.804 ± 0.67 and 19.011 ± 9.82 mg/mL in the aqueous and hydroalcoholic extracts, respectively. The inhibition of glucose uptake by yeast recorded a high inhibitory capacity at 50 mg/mL of glucose.

Conclusion. We found that the antioxidant and anti-diabetic activity of P. granatum leaves extracts was due to the presence of bioactive compounds such as flavonoids, which is why they are effective in preventing diabetes and its complications.
Yeast-rich mannan fractions in duck cultivation: prospects of using
Authors: Kasjanenko Sergij , Kasjanenko Oksana , Nagornaya Liudmyla , Yevstafieva Valentyna , Melnychuk Vitaliy , Lukyanova Galina , Gurenko Irina
Published: August 2020

Introduction. Due to the trend of avoiding antibiotics and acquiring eco-friendly products, the use of environmentally safe preparations is becoming increasingly relevant in poultry farming.

Study objects and methods. We used Salmonella enteritidis and Campylobacter jejuni isolated from poultry carcasses. At the first in vitro stage, we studied the ability of mannan oligosaccharides, isolated from the cell walls of Saccharomyces cerevisiae yeast, to adsorb bacterial pathogens. At the second stage, we studied the influence of fraction on the activity, colonization and microflora composition of ducklings’ intestines. At the third stage, we determined the antagonistic activity of Bifidobacterium spp. (Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium bifidum) and Lactobacillus spp. (Lactobacillus fermentun, Lactobacillus salivarius, Lactobacillus acidophilus) against Salmonella enteritidis and Campylobacter jejuni isolates. The experiment was conducted on the ducklings of Star 53 H.Y. cross. Their diet was supplemented with probiotics, prebiotics, and their combination.

Results and discussion. In vitro studies showed the ability of mannan oligosaccharides isolated from the cell walls of Saccharomyces cerevisiae yeast to adsorb Salmonella enteritidis and Campylobacter jejun. In vivo experiment showed the ability of mannan oligosaccharides to prevent colonization of poultry intestines by bacterial pathogens with type I fimbriae.

Conclusion. The reisolation rate of ducks infected with Salmonella enteritidis was 53.6% lower, and those infected with Campylobacter jejuni, 66.2% lower than the control. Mannan oligosaccharides added to the diet did not affect the concentration of lactobacilli, enterococci, and anaerobic bacteria in the ducks’ intestines. A combined use of Bifidobacterium spp. and mannan oligosaccharides improved the preservation of poultry stock by 8.7%, which made it an effective way to prevent poultry salmonellosis.
Mechano-chemo-biological Computational Models for Arteries in Health, Disease and Healing: From Tissue Remodelling to Drug-eluting Devices
Authors: Marino Michele , Vairo Giuseppe , Wriggers Peter
Published: August 2020

This review aims to highlight urgent priorities for the computational biomechanics community in the
framework of mechano-chemo-biological models. Recent approaches, promising directions and open challenges
on the computational modelling of arterial tissues in health and disease are introduced and investigated, together
with in silico approaches for the analysis of drug-eluting stents that promote pharmacological-induced healing.
The paper addresses a number of chemo-biological phenomena that are generally neglected in biomechanical
engineering models but are most likely instrumental for the onset and the progression of arterial diseases. An
interdisciplinary effort is thus encouraged for providing the tools for an effective in silico insight into medical
problems. An integrated mechano-chemo-biological perspective is believed to be a fundamental missing piece for
crossing the bridge between computational engineering and life sciences, and for bringing computational biomechanics
into medical research and clinical practice.
Cyclopropyl Scaffold: A Generalist for Marketed Drugs
Authors: Sun Mo-Ran , Li Hong-Liang , Ba Meng-Yu , Cheng Weyland , Zhu Hai-Liang , Duan Yong-Tao
Published: August 2020

In recent decades, much attention has been given to cyclopropyl scaffolds, which commonly
exist in natural products and synthetic organic molecules. Clinical drug molecules with cyclopropyl
rings are an area of focus in therapeutic research due to their interesting chemical properties and
unique pharmacology activity. These molecular drugs against different targets are applicable in some
therapeutic treatment fields including cancer, infection, respiratory disorder, cardiovascular and cerebrovascular
diseases, dysphrenia, nervous system disorders, endocrine and metabolic disorders, skin
disease, digestive disorders, urogenital diseases, otolaryngological and dental diseases, and eye diseases.
This review is a guide for pharmacologists who are in search of valid preclinical/clinical drug compounds
where the progress, from 1961 to the present day, of approved marketed drugs containing cyclopropyl
scaffold is examined.
Pharmacological Strategy for Congenital Myasthenic Syndrome with CHRNE Mutations: A Meta-Analysis of Case Reports
Authors: Huang Kun , Luo Yue-Bei , Bi Fang-Fang , Yang Huan
Published: August 2020

Background:

Congenital myasthenic syndromes (CMSs) are a heterogeneous group of
neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene
(CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition
by clinicians. However, pharmacological treatment of CMS with CHRNE mutations has only
been discussed in a small number of case reports.

Objective:

This study aims to determine how to choose an appropriate pharmacological strategy for
CMS with CHRNE mutations.

Methods:

A meta-analysis was performed. PubMed, MEDLINE, Web of Science, and Cochrane Library
databases were searched for studies published in English prior to June 1, 2020. The extracted
data included clinical information, gene mutations, pharmacological treatment, and treatment effects.

Results:

A total of 48 studies and 208 CMS patients with CHRNE mutations were included in our
meta-analysis. Ten different pharmacological strategies were used in these patients. Our research
found that β2-adrenergic receptor agonists had the best treatment effect for CMS patients with
CHRNE mutations, especially in patients with primary AChR deficiency. In addition, our analysis
found no evidence that age at disease onset influences the treatment results.

Conclusions:

This meta-analysis provides evidence that (1) β2-adrenergic receptor agonist therapy
could be the first choice of pharmacological strategy for treating CMS with CHRNE mutations; (2)
a single-drug-regime, rather than a combination therapy, should be the first choice of treatment;
and (3) it is never too late to initiate pharmacological treatment.
Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry
Authors: Fanet H. , Capuron L. , Castanon N. , Calon F. , Vancassel S.
Published: August 2020

Tetrahydrobipterin (BH4) is a pivotal enzymatic cofactor required for the synthesis of
serotonin, dopamine and nitric oxide. BH4 is essential for numerous physiological processes at periphery
and central levels, such as vascularization, inflammation, glucose homeostasis, regulation
of oxidative stress and neurotransmission. BH4 de novo synthesis involves the sequential activation
of three enzymes, the major controlling point being GTP cyclohydrolase I (GCH1). Complementary
salvage and recycling pathways ensure that BH4 levels are tightly kept within a physiological
range in the body. Even if the way of transport of BH4 and its ability to enter the brain after peripheral
administration is still controversial, data showed increased levels in the brain after BH4
treatment. Available evidence shows that GCH1 expression and BH4 synthesis are stimulated by
immunological factors, notably pro-inflammatory cytokines. Once produced, BH4 can act as an anti-
inflammatory molecule and scavenger of free radicals protecting against oxidative stress. At the
same time, BH4 is prone to autoxidation, leading to the release of superoxide radicals contributing
to inflammatory processes, and to the production of BH2, an inactive form of BH4, reducing its
bioavailability. Alterations in BH4 levels have been documented in many pathological situations,
including Alzheimer's disease, Parkinson's disease and depression, in which increased oxidative
stress, inflammation and alterations in monoaminergic function are described. This review aims at
providing an update of the knowledge about metabolism and the role of BH4 in brain function,
from preclinical to clinical studies, addressing some therapeutic implications.
Rebalancing the Oral Microbiota as an Efficient Tool in Endocrine, Metabolic and Immune Disorders
Authors: Isacco Ciro Gargiulo , Ballini Andrea , De Vito Danila , Nguyen Kieu Cao Diem , Cantore Stefania , Bottalico Lucrezia , Quagliuolo Lucio , Boccellino Mariarosaria , Di Domenico Marina , Santacroce Luigi , Arrigoni Roberto , Dipalma Gianna , Inchingolo Francesco
Published: August 2020

The current treatment and prevention procedures of oral disorders follow a very targeted
approach considering mouth and its structures as a system that is completely independent, than the rest
of the body. The main therapeutic approach is to keep the levels of oral bacteria and hygiene in an
acceptable range compatible with oral-mouth health, completely separated from systemic microbial
homeostasis (eubiosis vs dysbiosis). This can negatively impact the diagnosis of a more complex systemic
disease and its progression. Dysbiosis occurs as a consequence of imbalance in oral and gut microbiota
which leads to cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, and Alzheimer’s
disease, as reported in current literature. Likewise, there is a need to highlight and develop a
novel philosophical approach in the treatments for oral diseases that will necessarily involve nonconventional
approaches.
What is the Impact of Cinnamon Supplementation on Blood Pressure? A Systematic Review and Meta-Analysis
Authors: Ghavami Abed , Haghighian Hossein K. , Roshanravan Neda , Ziaei Rahele , Ghaedi Ehsan , Moravejolahkami Amir R. , Askari Gholamreza
Published: August 2020

Background and Aims:

This study was designed to make a systematic review and meta-analysis on randomized
controlled trials (RCTs) assessing the effect of cinnamon on blood pressure (BP).

Methods:

A systematic computerized literature search of PubMed, Scopus, Web of Science, Cochrane Library and Google
Scholar databases were conducted up to August 2019. All RCTs using cinnamon supplements in adults were included in this
systematic review and meta-analysis.

Results:

Out of 927 records, 8 trials that enrolled 582 participants were included. The pooled effect
size showed that SBP did not change following cinnamon supplementation. (WMD: -0.61mmHg; 95%
CI: -1.36, 0.14, P= 0.111). Also cinnamon supplementation in long-duration (≥ 8weeks) had a significant
effect on SBP (WMD: -1.25 mmHg; 95% CI: -2.22, -0.28, P= 0.012). Pooled analysis showed that
cinnamon had a significant effect on DBP (WMD: -0.93mmHg, 95% CI: -1.55 to -0.32, P= 0.003). In
addition, results from both duration subsets and high dose (>1500 mg/day) of cinnamon supplementation
were significant.

Conclusion:

Our findings revealed that cinnamon supplementation has favorable effects on DBP although results about SBP
were not the same. Nonetheless, further studies are required.
Anti-Neuroinflammatory Properties of n-3 Fatty Acids and Nano- Curcumin on Migraine Patients from Cellular to Clinical Insight: A Randomized, Double-Blind and Placebo-Controlled Trial
Authors: Honarvar Niyaz M. , Soveid Neda , Abdolahi Mina , Djalali Mahmoud , Hatami Mahsa , Karzar Nazanin H.
Published: August 2020

Background and Objectives:

Migraine is an exhausting neuro-inflammatory disorder recognized
as recurrent headache attacks. Evidence has shown that Interleukin (IL)-1β plays a substantial
role in the neuro-immunity pathogenicity of migraine. n-3 fatty acids and curcumin revealed neuromodulatory
and anti-inflammatory effects through several pathways, of which the suppression of IL-1β
gene expression is an important inflammatory pathway. The aim of this study was the investigation of
synergistic relation of n -3 fatty acids and nano-curcumin on IL-1β gene expression and serum levels in
migraine patients.

Methods:

This study was performed as a randomized, double-blind, placebo-controlled trial in a period
of two months. A total of 80 episodic migraines were assigned into 4 groups of 1) n-3 fatty acids and
curcumin combination; 2) n -3 fatty acids; 3) nano-curcumin; and 4) n-3 fatty acids and curcumin placebo.
The gene expression and serum level of IL-1β were measured by real-time PCR and ELISA
methods respectively, at the beginning and the end of the interventions.

Results:

Results showed the n-3 fatty acids and nano-curcumin combination significantly reduced the
attack frequency in a synergistic status (P <0.001). A significantly greater reduction in the serum level
of IL-1β was observed in the combination group, and the differences in the other groups were not statistically
significant. The IL-1β gene expression in the combination group showed a significant reduction
for other treatment groups (P < 0.05), but these significant differences were absent after multiple
testing Bonferroni corrections.

Conclusion:

Present findings revealed that n -3 fatty acids and curcumin co-supplementation can be
suggested as a promising new approach in migraine headache management, but further studies are
needed to confirm these findings.
Comparison of 24-Hour Electrocardiogram Parameters in Patients with Graves’ Disease Before and After Anti-Thyroid Therapy
Authors: Akkuş Gamze , Sökmen Yeliz , Yılmaz Mehmet , Bekler Özkan , Akkuş Oğuz
Published: August 2020

Background:

We aimed prospectively to investigate the laboratory and electrocardiographic
parameters (heart rate, QRS, QT, QTc, Tpe, Tpe/QTc, and arrhythmia prevalence) in patients with
Graves’ disease before and after antithyroid therapy.

Methods:

Seventy-one patients (48 female, and 23 male), of age between 18-50 years (mean±SD:
36.48±12.20) with GD were included in the study. Patients were treated with antithyroid therapy
(thioamides and/or surgical therapy) to maintain euthyroid status. Patients were examined in terms of
electrocardiographic parameters before and after the treatment.

Results:

ean TSH, free thyroxin (fT4), and tri-iodothyrionine (fT3) levels of all patients were
0.005±0.21, 3.27± 1.81, 11.42±7.44, respectively. While 9 patients (group 2) underwent surgical therapy,
had suspicious malignant nodule or large goiter, and unresponsiveness to medical treatment; the
other patients (n=62, group 1) were treated with medical therapy. Patients with surgical therapy had
more increased serum fT4 (p=0.045), anti-thyroglobulin value (p=0.018) and more severe graves orbitopathy
(n=0.051) before treatment when compared to a medical therapy group. Baseline Tpe duration
and baseline Tpe/QTc ratio and frequency of supraventricular ectopic beats were found to be significantly
higher in group 2 when compared to group 1 (p=0.00, p=0.005). Otherwise, the baseline mean
heart rate, QRS duration, QTc values of both groups were similar. Although the patients came at their
euthyroid status, group 2 patients still suffered from more sustained supraventricular ectopics beats
than group 1.

Conclusion:

Distinct from the medical treatment group, surgical treatment group with euthyroidism for
at least 3 months still suffered from an arrhythmia (Tpe, Tpe/QTc, supraventricular and ventricular
ectopic beats).
Historical Anecdotes and Breakthroughs of Histamine: From Discovery to Date
Authors: Charitos Ioannis A. , Castellaneta Francesca , Santacroce Luigi , Bottalico Lucrezia
Published: August 2020

Aim:

Investigating about the history of allergies and discovery of the histamine’s role in the immune response through historical references, starting with ancient anecdotes, analysing the first immunization attempts on animals to understand its importance as the anaphylaxis mediator. Moreover, we shortly resume the most recent discoveries on mast cell role in allergic diseases throughout the latest updates on its antibody-independent receptors.

Methods:

Publications, including reviews, treatment guidelines, historical and medical books, on the topic of interest were found on Medline, PubMed, Web of Knowledge, Web of Science, Google Scholar, Elsevier’s (EMBASE.comvarious internet museum archives. Texts from the National Library of Greece (Stavros Niarchos Foundation), from the School of Health Sciences of the National and Kapodistrian University of Athens (Greece). We selected key articles which could provide an historical and scientific insight into histamine molecule and its mechanism of action’s discovery starting with Egyptian, Greek and Chinese antiquity to end with the more recent pharmacological and molecular discoveries.

Results:

Allergic diseases were described by medicine since ancient times, without exactly understanding physio-pathologic mechanisms of immuno-mediated reactions and of their most important biochemical mediator, histamine. Researches on histamine and allergic mechanisms started at the beginning of the 20th century with the first experimental observations on animals of anaphylactic reactions. Histamine was then identified as their major mediator of many allergic diseases and anaphylaxis, but also of several physiologic body’s functions, and its four receptors were characterized. Modern researches focus their attention on the fundamental role of the antibody-independent receptors of mast cells in allergic mechanisms, such as MRGPRX2, ADGRE2 and IL-33 receptor.

Conclusion:

New research should investigate how to modulate immunity cells activity in order to better investigate possible multi-target therapies for host’s benefits in preclinical and clinical studies on allergic diseases in which mast cells play a major role.
The Impact of Comorbid Diabetes Type 2 on Quality of Life in Cancer Patients Undergoing Chemotherapy
Authors: Lavdaniti Maria , Michalopoulou Styliani , Owens Dimitra-Anna , Vlachou Eugenia , Kazakos Kyriakos
Published: August 2020

Background and Objective:

Cancer and diabetes are two highly prevalent diseases
worldwide and greatly influence quality of life of those suffering from it. The study aimed to compare
quality of life in patients diagnosed with cancer and diabetes with those without diabetes both
undergoing chemotherapy and to investigate the factors responsible for the difference between the
two groups.

Methods:

A convenience sample of 101 participants who had cancer and type 2 diabetes and 99
who had cancer without diabetes were used.

Results:

Patients with comorbid diabetes were divided based on their diabetes duration and
whether they had glycaemic control or not. Diabetic cancer patients without glycaemic control had
lower scores in global health status and in physical and emotional functioning compared to diabetic
cancer patients with glycaemic control and patients without diabetes (p < .05). After adjusting for
demographic characteristics, the differences between the group with diabetes and without glycaemic
control and the other two groups regarding global health status were statistically significant
(p < .05). Patients with more than a 7-year history of diabetes had a significantly lower emotional
functioning than the no diabetes group and lower global health status score than both of the other
groups (p < .05). After adjusting for clinical and demographic characteristics, only the difference
between the ≥ 7 years diabetes duration group and the no diabetes groups remained significant.

Conclusion:

The presence of diabetes in cancer patients who underwent chemotherapy seems to
negatively influence certain domains of quality of life and this may be affected by the duration of
diabetes and whether glycaemic control has been achieved or not.
Improving the speaking learning process to the students of grade VIII through games
Authors: Purnamu Chatarina Heny Eka , Priyana Joko
Published: August 2020

This study was aimed at improving  the speaking learning process to the students of grade VIII at SMPN 3 Cilacap through games in the academic year of 2013/2014. This classroom action research was carried out in two cycles. The cyclical design consisted of four main steps: (1) planning, (2) action, (3) observation, and (4) reflection. Various games with some supporting activities were implemented in this study. The data were gathered through observations, interview, rating, video/audio recording, and performance tests. The data were analyzed using the interactive qualitative data analysis and descriptive statistics.  The findings show that games which are set up properly involved preliminary activities, game play and closure, together with some supporting activities are able to improve the speaking learning process. The implementation of games is effective to lessen the interference of the native language, lessen the students’ domination in the class, encourage the students’ initiation to speak English, give the students plenty of opportunities to speak as often as possible and encourage the students to focus on fluency rather than accuracy, encourage the students’ confidence, and increase the students’ involvement in the learning process. These improvements lead to the improvements of the students’ speaking skills. The students’ average score in performance test before implementing the actions is 63,39 while after implementing the actions is 81,64. It shows that it increases about 28,77%. It can be inferred that the students’ speaking skills improved after the implementation of the games.
Developing an Interactive HTML5-Based Game for Tenses Learning for Senior High School Students
Authors: Purinanda Faza Hannan
Published: August 2020

This research study aims at developing an interactive HTML5-based game to facilitate senior high school students in learning tenses. This research is a research and development study. The development of the game is carried out through several steps, which are needs analysis, outline of materials design, product development, expert judgement, product revision, and final product development. The result of this study is a web-based game titled The Time Traveller. Based on the results of expert judgement, the game is appropriate for senior high school students based on the mean scores of 3.52, which is in the range of 3.25 ≤ x ≤ 4 and falls into the category of “Very Good.”
Kualitas hidup lansia hipertensi dengan overweight dan tidak overweight
Authors: Khasana Tri Mei , Kertia Nyoman , Probosuseno Probosuseno
Published: August 2020

The quality of life in elderly hypertension with overweight and non-overweightBackground: Indonesia will enter the period of aging and an increase in several elderlies with chronic diseases. The biggest health problems of the elderly are degenerative diseases, namely hypertension which significantly disrupts the quality of life both in terms of physical and mental health. One of the causal conditions associated with hypertension is overweight and obesity, which is known at this time the prevalence of obesity is growing progressively in old age. However, the results of research related to the influence of obesity on quality of life are still controversial.Objective: To determine differences in quality of life between hypertensive elderly who are overweight and non-overweight.Method: Cross-sectional study conducted in Yogyakarta City in Januari-April 2017 with a subject of 200 elderly people aged 60-74 years. Overweight was determined based on BMI measurements (>23 kg/m2) with an estimation of elderly height using depa length, quality of life of the elderly was measured using WHOQOL-BREF questionnaire, and compared the quality of life by age, gender, education, occupation, income, marital status, comorbidity, and disease history. Data analysis used independent t-test and linear regression.Results: Mean of environmental domain score was significantly higher (p=0,012) in elderly hypertension with overweight (26,69±3,28) compared to elderly hypertension non-overweight (25,44±3,58). Overweight protective effect on the low quality of life of the environment domain because it is influenced by other factors such as marital status, income, and education. Multivariate analysis shows that income and marital status are external factors that consistently influence the quality of life of the elderly both in total scores and per domain. High-income elderly people with married status have a better quality of life score.Conclusions: The mean score of the environmental domain is higher in elderly hypertension with overweight. Quality of life scores will be better in high income elderly and married.
Kepadatan tulang santriwati berhubungan dengan profil antropometri
Authors: Dieny Fillah Fithra , Jauharany Firdananda Fikri , Tsani A Fahmy Arif , Rahadiyanti Ayu
Published: August 2020

Santriwati’s bone mass density was associated with the anthropometric profileBackground: One group of female adolescents who had nutritional problems was Islamic boarding school students, namely santriwati. Low intake was supported by a poor diet profile that had a risk of developing osteopenia. The problem of osteopenia in adolescents could affect long-term calcium deposits and had an impact on old age and a high risk of osteoporosis.Objective: This study aims to examine the relationship between diet profiles and anthropometric profiles with bone density in female students.Methods: A cross-sectional study of 76 female students who were selected using a simple random sampling technique. Anthropometric profiles measured were body mass index, body fat percent, and waist circumference. Bone density was measured using Dual Energy X-Ray Absorptiometry (DXA). Nutrient intake profiles were obtained based on intake interviews used food recall form 6x24 hours. Data were analyzed using Spearman correlations.Results: Most female students had normal nutritional status, and 14 female students (18.4%) had low bone density. The intake of energy, macronutrients (protein, fat, and carbohydrate), and micronutrients (phosphorus, calcium, and vitamin D) of female students were insufficient. There was a relationship between body mass index (p=0.036; r=0.241) and percent body fat (p=0.027; r=0.254) with bone density. However, the nutrient intake factor has no relationship with bone density (p>0.05).Conclusions: Body mass index and body fat percent are positively correlated with female bone density.
Early introduction of complementary food and childhood stunting were linked among children aged 6-23 months
Authors: Paramashanti Bunga Astria , Benita Stella
Published: August 2020

Background: Indonesia’s national stunting prevalence remains high. The transition from exclusive breastfeeding to poor complementary feeding practices may put infants at higher risk of becoming stunting. Objective: This study aimed to analyze the relationship between the early introduction of complementary food and stunting among young children aged 6-23 months in Kebumen Regency. Methods: A cross-sectional study design was conducted among 307 young children in Kebumen Regency, Central Java Province, Indonesia, by using multistage cluster sampling. Our primary outcome was stunting or height-for-age z-score <-2, whereas independent variables were child, maternal, and household factors. Univariate and multivariate logistic regression were performed to assess significant determinants at the level of significance 0.05. Results: Timely introduction of complementary food was a protective factor against stunting (AOR= 0.54; 95%CI: 0.31-0.94). Female children were less likely to be associated with stunting (AOR= 0.54; 95%CI: 0.32-0.93). Conversely, variables which significantly increased the risk of becoming stunting included older children aged 12-17 months (AOR= 2.01; 95%CI: 1.05-3.84) and 18-23 months (AOR= 4.17; 95%CI: 2.15-8.08) and maternal occupation in agricultural sectors (AOR= 3.77; 95%CI: 1.17-12.1). Conclusions: Child factors associated with stunting was the first timing of complementary feeding, child sex, and child age. The maternal factor linked to stunting was the mother's occupation in the agricultural sector. This study indicated that child and maternal factors play essential roles in childhood stunting.
The correlation between vitamin D deficiency and the severity of painful diabetic neuropathy in patients with type 2 diabetes mellitus (T2DM)
Authors: Pinzon Rizaldy Taslim , Gelgel Putu Clara Shinta
Published: August 2020

Background: Diabetes and its complications are the major burden health problem worldwide, and diabetic neuropathy is one of the major complications. Vitamin D levels found to be significantly lower in people with painful diabetic peripheral neuropathy compared with healthy people. The data about the vitamin D levels and severity of the neuropathy in Indonesia are very limited.Objective: This study aims to investigate the possible relationship between vitamin D levels and the severity of diabetic peripheral neuropathy.Methods: A cross-sectional study was carried out during the period from October 2019 to December 2019 on 53 subjects with diabetic peripheral neuropathy. The patient’s clinical profile including age, gender, and duration of diabetes, HbA1c, and associated microvascular complications was documented. The treatment history was recorded from electronic prescribing data. The severity of neuropathy was measured with the Toronto Clinical Neuropathy Scoring System. Serum 25-OH vitamin D levels were measured by enzyme immunoassays for the quantitative measurement of total serum 25-OH Vitamin D level in ng/mL.Results: Vitamin D levels based on the severity of neuropathy are divided into mild, moderate, and severe. At mild neuropathy severity, the average patient's vitamin D level was 19±8.85ng/mL, at moderate severity the patient's vitamin D level was 16.25±6.08 ng/mL, and for severe neuropathy, the average vitamin D level was 13.35±6.20 ng/mL. Spearman correlation test obtained r value= -0.439 and p value=0.001.Conclusions: There is a moderate, significant, and negative patterned correlation between vitamin D level and diabetic peripheral neuropathy severity
Interpretation of the Silence of the Lambs from the Perspective of Horizon of Expectation
Authors: GAO Pei
Published: August 2020

The silence of the lambs is one of the most influential crime novels of its time. The author Thomas Harris vividly depicts the characters and their psychological activities. He created the atmosphere of tension and horror through unique methods, breaking through people’s horizon of expectation, and generating unprecedented experience to readers in the creation process of the novel. At the same time, he created characters that broke people’s prescribed interpretation of the protagonist of crime novels and exceeded readers’ expectations. The aim of this paper is to gain more insight into this great work from the perspective of Horizon of Expectation.