bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Optically Active Phenanthrolines in Asymmetric Catalysis. Part 3. Highly Efficient Enantioselective Transfer Hydrogenation of Acetophenone by Chiral Rhodium/3‐Alkylphenanthroline Catalysts.
Authors: GLADIALI S. , PINNA L. , DELOGU G. , DE MARTIN S. , ZASSINOVICH G. , MESTRONI G.
Published: May 2016

The title phenanthrolines, e.g. (III) and (VI), are applied to the rhodium‐catalyzed transfer hydrogenation of the ketone (VII).
ChemInform Abstract: Dramatic Enantioselectivity Change in Dihydroxylation of Olefins with Chiral Amine‐Osmium Tetroxide Complex.
Authors: TOMIOKA K. , NAKAJIMA M. , KOGA K.
Published: May 2016

The chiral bispyrrolidines (I) are tested as ligands in the dihydroxylation of various olefins with osmium tetroxide.
ChemInform Abstract: Cobalt(III) Chloride‐Catalyzed Condensation of Acetoacetate with Vinyl Ethers.
Authors: IQBAL J. , SRIVASTAVA R. R. , KHAN M. A.
Published: May 2016

Methyl acetoacetate (I) reacts with vinyl isobutyl ether (II) in the presence of catalytic amounts of CoCl2 to give a mixture of the diastereomeric addition products (III) and (IV) with the predominance of the threo‐isomer (III).
ChemInform Abstract: Regio‐ and Stereocontrolled Synthesis of Hydroxycyclohexenyl Sulfones from Oxanorbornenes.
Authors: ARJONA O. , FERNANDEZ DE LA PRADILLA R. , MALLO A. , PLUMET J. , VISO A.
Published: May 2016

The oxanorbornenyl phenyl sulfones (I) react with the organolithium compounds (II) in a regio‐ and stereospecific manner to give the hydroxycyclohexenyl sulfones (III).
ChemInform Abstract: Facile Catalytic Conversion of Carboxylic Acids into Thiocarboxylic S‐Acids by the Ph3SbO/P4S10 System.
Authors: NOMURA R. , MIYAZAKI S.‐I. , NAKANO T. , MATSUDA H.
Published: May 2016

The title reaction provides the thiocarboxylic acids (II) or (IV).
ChemInform Abstract: Bicyclo(3.3.1)nonanes as Synthetic Intermediates. Part 17. A Novel Interconversion Between Bicyclo(4.3.1)decane and Tricyclo(4.3.1.0)decane Systems via the Dual Mode of Aldol Cyclization of Bicyclo(4.3.1)decane‐3,8‐dione.
Authors: MOMOSE T. , MASUDA K. , FURUSAWA S. , MURAOKA O. , ITOOKA T.
Published: May 2016

Ring expansion of the (aminomethyl)hydroxyoxaadamantane (I) is achieved via diazotization and subsequent denitrogenation at 0°C to generate the bicyclic dione (II).
ChemInform Abstract: Stereoselective Preparation of (1S,2R)‐ and (1S,2S)‐2‐Hydroxy‐7,7‐dimethylbicyclo(2.2.1)heptane‐1‐carboxylic Acids.
Authors: ISHIZUKA T. , KIMURA K. , ISHIBUCHI S. , KUNIEDA T.
Published: May 2016

Starting with (1S)‐ketopinic acid (I), the esters (III) are prepared by conventional methods.
ChemInform Abstract: Ferroelectric Liquid Crystalline Compounds Having a Chiral Center Directly Connected to the Core Aromatic Ring. Synthesis of Chiral 4‐(1‐Propoxyethyl)benzenol and ‐benzoic Acid, 4‐(1‐Carboxyethyl)benzenol, and the Ester Derived Therefrom.
Authors: KUSUMOTO T. , UEDA T. , HIYAMA T. , TAKEHARA S. , SHOJI T. , OSAWA M. , KURIYAMA T. , NAKAMURA K. , FUJISAWA T.
Published: May 2016

Methyl 4‐acetylbenzoat (I) is reduced with Corey's reagent as the catalyst to form the alcohol (II) which is etherified and hydrolyzed to give the benzoic acid (IV).
ChemInform Abstract: Oxygen Ligation in the Nickel‐Mediated (2 + 2 + 2) Cocyclisation of a Hepta‐1,6‐diyne and Alkynol Derivatives.
Authors: BHATARAH P. , SMITH E. H.
Published: May 2016

The yields of products such as (III) depend on the position and the steric environment of the oxygen atom.
ChemInform Abstract: Reaction of N‐Trimethylsilyl Benzil Monoimine with Simple Lithium Ester Enolates. A Synthetic Tool for the Regioselective One‐Pot Preparation of Novel Polyfunctional Pyrrolines.
Authors: ALCAIDE B. , RODRIGUEZ‐LOPEZ J.
Published: May 2016

Depending of the nature of the enolate in the title reaction, various polyfunctional pyrrolines are formed.
ChemInform Abstract: Synthesis of Thiazolidine‐2,5‐dithiones; Characterisation of 4‐Substituted Thiazolidinedithiones.
Authors: YAMAMOTO T. , ITOH M. , SAITOH N. U. , MURAOKA M. , TAKESHIMA T.
Published: May 2016

The compounds such as (III) and (V) are prepared by a general and simple method.
ChemInform Abstract: The Reactivity of Naphthopyran‐2‐one Derivatives Toward Nucleophilic and Electrophilic Reagents.
Authors: SALEH R. M. , SOLIMAN A. Y. , EL‐NAGDY S. , BAKEER H. M. , MOSTAFA M. M.
Published: May 2016

Claisen condensation of 4‐methyl‐2H‐naphtho(1,2‐b)pyran‐2‐one (I) with the esters (II) produces the 4‐acetonyl derivatives (III).
ChemInform Abstract: Preparation of New Nitrogen‐Bridged Heterocycles. Part 22. A New Approach to the Synthesis of Thienoindolizine Derivatives.
Authors: KAKEHI A. , ITO S. , YAMADA N. , YAMAGUCHI K.
Published: May 2016

The cyanoethylthioindolizines (I) are S‐dealkylated and then α‐oxoalkylated with the halides (IV) to form the indolizinylthiomethyl ketones (V).
ChemInform Abstract: Synthesis and CNS‐Activity of cis‐Pyrano(2,3‐b)(1,4)dioxane Derivatives.
Authors: EIDEN F. , WUENSCH B. + , SCHUENEMANN J. +
Published: May 2016

Reaction of the saturated pyranodioxinone derivative (I) with the amines (II) and (IV) or hydroxylamine hydrochloride (VI), accompanied or followed by reduction, produces mixtures of the aminopyranodioxanes (III), (V), or (VII).
ChemInform Abstract: Synthesis of C‐ and N‐Functionalised Derivatives of 1,4,7‐Triazacyclononane‐1,4,7‐triyltriacetic Acid (NOTA), 1,4,7,10‐Tetraazacyclododecane‐1,4,7,10‐tetrayltetraacetic Acid (DOTA), and Diethylenenetriaminepentaacetic Acid (DTPA): Bifunctional Complexing Agents for the Derivatisation of Antibodies.
Authors: COX J. P. L. , CRAIG A. S. , HELPS I. M. , JANKOWSKI K. J. , PARKER D. , EATON M. A. W. , MILLICAN A. T. , MILLAR K. , BEELEY N. R. A. , BOYCE B. A.
Published: May 2016

Reactive title compounds such as (X) and (XVI) are attached to monoclonal antibodies for use in tumor targeting.
ChemInform Abstract: Tricyclic Neuroleptics: Synthesis of Metabolites of Isofloxythepin and Some Related Compounds.
Authors: SINDELAR K. , JILEK J. , POMYKACEK J. , VALENTA V. , HRUBANTOVA M. , VLKOVA M. , HOLUBEK J. , SVATEK E. , RYSKA M. , METYSOVA J. , PROTIVA M.
Published: May 2016

The metabolites (VII) and (IX) of the neuroleptic agent isofloxythepin (X) and some related compounds are prepared.
ChemInform Abstract: 3‐Arsolenes.
Authors: SCHENK W. A. , VOSS E.
Published: May 2016

The synthesized arsolenes (III) can be methylated to give their arsonium salts such as (V).
ChemInform Abstract: Synthesis and Reactivity of 1,2‐ and 1,4‐Dihydroxyarene Complexes of Chromium Tricarbonyl.
Authors: SCHUMANN H. , ARIF A. M. , RICHMOND T. G.
Published: May 2016

The title complexes such as (IV) and (VII) are prepared using SiMe3‐protected 1,4‐ or 1,2‐dihydroxyarenes as starting material.
ChemInform Abstract: Synthesis of Organometallic Hydrotris(pyrazol‐1‐yl)boratoruthenium(II) Complexes.
Authors: HILL A. F.
Published: May 2016

The title complexes (IIIa) and (IIIb) are obtained from the unsaturated σ‐vinyl complexes (I) and the related σ‐aryl complex (IV) in high yields as shown in the scheme.
ChemInform Abstract: Thermal Analysis for the 1990s
Authors: SEVERAL AUTHORS SEVERAL AUTHORS
Published: May 2016

(collection of papers presented at the 18. North American Thermal Analysis Society Conference, San Diego, CA, USA, Sept.
ChemInform Abstract: Crystal Growth and Magnetic Characterization of a Tetragonal Polymorph of NiNb2O6.
Authors: Munsie T. J. S. , Millington A. , Dube P. A. , Dabkowska H. A. , Britten J. , Luke G. M. , Greedan J. E.
Published: May 2016

Single crystals of NiNb2O6 are grown in an optical floating zone furnace using a 1.2% molar excess of NiO in a sintered columbite rod as well as a pure O2 atmosphere and a growth rate of 25 mm/h.
ChemInform Abstract: A Facile Method for the Synthesis of Binary Tungsten Iodides.
Authors: Stroebele Markus , Castro Cristina , Fink Reinhold F. , Meyer H.‐Juergen
Published: May 2016

The new compounds W3I12 (I) and W3I9 (II) containing the novel [W3I8] cluster are prepared by halide exchange reaction between WCl6 and SiI4 at 120 °C for 16 h and 150 °C for 12 h, respectively (98% yield for (I)).
ChemInform Abstract: [Cs6Cl][Fe24Se26]: A Host‐Guest Compound with Unique Fe—Se Topology.
Authors: Valldor Martin , et al.
Published: May 2016

Polycrystalline Se‐substituted bartonite [Cs6Cl][Fe24Se26] is obtained by annealing stoichiometric amounts of Cs2Se, CsCl, Fe, and Se (Al2O3 crucible in evacuated silica tubes, 500 °C, 60 h).
ChemInform Abstract: Water‐ and Temperature‐Triggered Reversible Structural Transformation of Tetranuclear Cobalt(II) Cores Sandwiched by Polyoxometalates.
Authors: Kuriyama Yosuke , Kikukawa Yuji , Suzuki Kosuke , Yamaguchi Kazuya , Mizuno Noritaka
Published: May 2016

Single crystals of (Bu4N)8H4 [{Co4(μ3‐OH)4} (SiW10O36)2]·5H2O (I) are precipitated by immersing (Bu4N)6H4 [{Co(H2O)}2(μ3‐OH)2{Co (H2O)2}2 (SiW10O36)2]·5H2O (II) in acetone followed by addition of a 1 M MeOH solution of (Bu4N)OH (313 K, 30 min, 64% yield).
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Allylic Alkylations with Toluene Derivatives as Pronucleophiles.
Authors: Mao Jianyou , Zhang Jiadi , Jiang Hui , Bellomo Ana , Zhang Mengnan , Gao Zidong , Dreher Spencer D. , Walsh Patrick J.
Published: May 2016

The first highly enantioselective Pd‐catalyzed allylic alkylation reactions using benzylic nucleophiles activated with Cr(CO)3 are developed.
ChemInform Abstract: Chelation‐Assisted Nickel‐Catalyzed Oxidative Annulation via Double C—H Activation/Alkyne Insertion Reaction.
Authors: Misal Castro Luis C. , Obata Atsushi , Aihara Yoshinori , Chatani Naoto
Published: May 2016

A Ni/NHC catalytic system for regioselective oxidative annulation by double C—H bond activation and concomitant alkyne insertion is described.
ChemInform Abstract: Enantioselective Syntheses of β‐Amino Alcohols Catalyzed by Recyclable Chiral Fe(III) Metal Complex.
Authors: Tak Rajkumar , Kumar Manish , Kureshy Rukhsana I. , Choudhary Manoj Kumar , Khan Noor‐ul H. , Abdi Sayed H. R. , Bajaj Hari C.
Published: May 2016

The title amino alcohols are prepared by asymmetric desymmetrization of meso‐epoxides with various anilines using a series of in situ generated chiral iron complexes based on chiral tridentate ligands as catalyst.
ChemInform Abstract: Nano PdAu Bimetallic Alloy as an Effective Catalyst for the Buchwald—Hartwig Reaction.
Authors: Chen Zheng , Wang Shuo , Lian Chao , Liu Yuxi , Wang Dingsheng , Chen Chen , Peng Qing , Li Yadong
Published: May 2016

Bimetallic Pd‐Au nanoparticles are synthesized by a convenient one‐pot wet chemical route and their catalytic activity in Buchwald—Hartwig reactions of aryl chlorides is examined.
ChemInform Abstract: 1,1,1,3,3,3‐Hexafluoroisopropanol as a Remarkable Medium for Atroposelective Sulfoxide‐Directed Fujiwara—Moritani Reaction with Acrylates and Styrenes.
Authors: Dherbassy Quentin , Schwertz Geoffrey , Chesse Matthieu , Hazra Chinmoy Kumar , Wencel‐Delord Joanna , Colobert Francoise
Published: May 2016

Access to atropo‐enantioenriched chiral biaryl moieties through asymmetric direct C—H activation is achieved using an enantiopure sulfoxide as both the directing group and chiral auxiliary.
ChemInform Abstract: E,Z‐Stereodivergent Synthesis of N‐Tosyl α,β‐Dehydroamino Esters via a Mukaiyama—Michael Addition
Authors: Espinosa Miguel , Garcia‐Ortiz Andrea , Blay Gonzalo , Cardona Luz , Munoz M. Carmen , Pedro Jose R.
Published: May 2016

by reaction of silylketene acetals with N‐tosylimines derived from β,γ‐unsaturated α‐ketoesters
ChemInform Abstract: A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access to meta‐Arylphenols.
Authors: Luo Junfei , Preciado Sara , Araromi Solomon Olatokunbo , Larrosa Igor
Published: May 2016

Various meta‐arylated phenols are efficiently synthesized by a three‐step sequence involving a palladium‐catalyzed oxidation of the salicylaldehyde followed by ortho‐arylation of the salicyl acid intermediate and protodecarboxylation of the arylated product.
ChemInform Abstract: Design, Synthesis and Docking Studies of Some Spiro‐Oxindole Dihydroquinazolinones as Antibacterial Agents.
Authors: Zhang Jin , Zhao Jiawen , Wang Liangpeng , Liu Jia , Ren Decheng , Ma Yangmin
Published: May 2016

Title compounds are conveniently and in excellent yields synthesized by a one‐pot process using cerium oxide nanoparticles as catalyst.
ChemInform Abstract: MnO2‐Promoted Carboesterification of Alkenes with Anhydrides: A Facile Approach to γ‐Lactones.
Authors: Wu Lihuan , Zhang Zhenming , Liao Jianhua , Li Jianxiao , Wu Wanqing , Jiang Huanfeng
Published: May 2016

The reaction proceeds via a radical mechanism and can be easily scaled up.
ChemInform Abstract: Spiromastilactones: A New Class of Influenza Virus Inhibitors from Deep‐Sea Fungus.
Authors: Niu Siwen , Si Longlong , Liu Dong , Zhou Andrew , Zhang Ziwei , Shao Zongze , Wang Shaomeng , Zhang Lihe , Zhou Demin , Lin Wenhan
Published: May 2016

Most of the novel spiromastilactones A—M (13 examples) shows inhibitory activities against WSN influenza virus with low cytotoxicity.
ChemInform Abstract: Synergistic Rhodium/Phosphoric Acid Catalysis for the Enantioselective Addition of Oxonium Ylides to ortho‐Quinone Methides.
Authors: Alamsetti Santosh Kumar , Spanka Matthias , Schneider Christoph
Published: May 2016

A novel and highly stereoselective method for the domino‐type reaction of diazoesters with in situ generated ortho‐quinone methides to furnish functionalized benzofuran derivatives with three contiguous stereogenic centers is reported.
ChemInform Abstract: An Easy One‐Step Synthesis of Imidazolin‐2‐ones from Phthalic Anhydrides and Their Antioxidant Evaluation.
Authors: Lopez Hector S. , Enciso Jose E. , Ochoa‐Teran Adrian , Velazquez Juan I. , Sarmiento Juan I.
Published: May 2016

Title compounds are prepared via two consecutive reactions and tested for their antioxidant activities.
ChemInform Abstract: Diastereodivergent Catalysis Using Modularly Designed Organocatalysts: Synthesis of Both cis‐ and trans‐Fused Pyrano[2,3‐b]pyrans.
Authors: Huang Huicai , Konda Swapna , Zhao John C.‐G.
Published: May 2016

Cis‐ and trans‐fused 3,4,4a,8a‐tetrahydro‐2H,5H‐pyrano[2,3‐b]pyran‐7‐carboxylates are obtained in high diastereoselectivities and enantioselectivities from the same starting materials using a tandem inverse‐electron‐demand hetero‐Diels—Alder/oxa‐Michael reaction catalyzed by modularly designed organocatalysts.
ChemInform Abstract: Synthesis of Allyl‐ and Prenylcoumarins via Microwave‐Promoted Tandem Claisen Rearrangement/Wittig Olefination.
Authors: Schmidt Bernd , Riemer Martin
Published: May 2016

A broad range of allyl, dimethylallyl, crotyl and prenyl ethers of variously substituted aromatic 2‐hydroxy carbonyl compounds are transformed according to the title reaction in the presence of a phosphorylide to form 6 or 8‐allylated or prenylated coumarine derivatives.
ChemInform Abstract: DABCO Catalyzed Domino Michael/Hydroalkoxylation Reaction Involving α‐Alkynyl‐β‐aryl Nitroolefins: Excellent Stereoselective Access to Dihydropyrano[3,2‐c]chromenes, Pyranonaphthoquinones and Related Heterocycles.
Authors: Biswas Soumen , Dagar Anuradha , Mobin Shaikh M. , Samanta Sampak
Published: May 2016

Construction of pharmaceutically interesting functionalized pyrano‐fused heterocycles, e.g. (III)/(IV), (VI)/(VII), and (IX)/(X), is achieved through a domino Michael/hydroxyalkoxylation reaction sequence involving several enolizable cyclic β‐keto esters/1,3‐dicarbonyls and nitrostyrene derivatives (II) as binucleophiles.
ChemInform Abstract: Efficient Pyrido[1,2‐a]benzimidazole Formation from 2‐Aminopyridines and Cyclohexanones under Metal‐Free Conditions.
Authors: Xie Yanjun , Wu Jun , Che Xingzong , Chen Ya , Huang Huawen , Deng Guo‐Jun
Published: May 2016

A new procedure is presented for the synthesis of pyrido[1,2‐a]benzimidazoles.
ChemInform Abstract: Copper‐Catalyzed Tandem Ullmann Type C—N Coupling and Dehydrative Cyclization: Synthesis of Imidazo[1,2‐c]quinazolines.
Authors: Nandwana Nitesh K. , Dhiman Shiv , Shelke Ganesh M. , Kumar Anil
Published: May 2016

An efficient one‐pot procedure is elaborated for the preparation of imidazo[1,2‐c]quinazolines (III) by an Ullmann‐type C—N coupling of bromides (I) with formamide followed by intramolecular dehydrative cyclization.
ChemInform Abstract: Synthesis of Isoselenocyanates.
Authors: Zakrzewski Jerzy , Huras Bogumila , Kielczewska Anna
Published: May 2016

An effective and reproducible method for the preparation of aryl and alkylisoselenocyanates via addition of selenium to either isocyanides or amines under phase‐transfer catalysis is developed.
ChemInform Abstract: Ammonium Iodide Catalyzed Selenolactonization of Unsaturated Acids.
Authors: Shi Hongwei , Yu Chen , Zhu Min , Yan Jie
Published: May 2016

The procedure is applicable to the synthesis of cyclic selenoethers as well as tellurocyclization products.
ChemInform Abstract: Phytosteroids and Triterpenoids with Potent Cytotoxicities from the Leaves of Chisocheton cumingianus.
Authors: Huang Shan‐Shan , Jian Kai‐Li , Li Rui‐Jun , Kong Ling‐Yi , Yang Ming‐Hua
Published: May 2016

Six new phytosteroids [e.g. (I)] and three new dammarane‐type triterpenoids [e.g. (II) and (III)] are isolated together with nine known triterpenoids.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Alstoscholarisine A
Authors: Bihelovic Filip , Ferjancic Zorana
Published: May 2016

via the domino reaction of amine (I) with aldehydes (II) and the subsequent DBU‐mediated epimerization
ChemInform Abstract: 1H‐Imidazol‐4(5H)‐ones and Thiazol‐4(5H)‐ones as Emerging Pronucleophiles in Asymmetric Catalysis
Authors: Mielgo Antonia , Palomo Claudio
Published: May 2016

Review: [115 refs.
ChemInform Abstract: Advances in Annulation Reactions Initiated by Phosphorus Ylides Generated in situ
Authors: Zhou Rong , He Zhengjie
Published: May 2016

Review: [57 refs.
ChemInform Abstract: Synthesis of Pyrazoles and Bipyrazoles ‐ A Review
Authors: Ur Rahman Mohammed Ehtesham , Faidallah Hassan M. , Kuerban AbuduKadeer , Naveed Abdul
Published: May 2016

Review: 76 refs.
ChemInform Abstract: The Synthetic Chemistry of Pillar[n]arenes
Authors: Cao Meijiao , Hao Yangweiwei , Xu Zhiqiang , Liu Sheng Hua , Yin Jun
Published: May 2016

Review: 101 refs.
ChemInform Abstract: Cutting‐Edge and Time‐Honored Strategies for Stereoselective Construction of C—N Bonds in Total Synthesis
Authors: Mailyan Artur K. , Eickhoff John A. , Minakova Anastasiia S. , Gu Zhenhua , Lu Ping , Zakarian Armen
Published: May 2016

Review: 824 refs.
ChemInform Abstract: α,β‐Unsaturated Aldehydes in the Synthesis of Five‐Membered Heterocyclic Compounds with One Heteroatom: Recent Advances from Developments in Metal‐ and Organocatalysis
Authors: Keiko N. A. , Vchislo N. V.
Published: May 2016

Review: [77 refs.
ChemInform Abstract: Gold‐Catalyzed Allylation Reactions
Authors: Quintavalla Arianna , Bandini Marco
Published: May 2016

Review: [features and limitations of some of the most salient gold‐mediated allylic alkylation protocols; 87 refs.
ChemInform Abstract: Facile Access to Fluoroaromatic Molecules by Transition‐Metal‐Free C—F Bond Cleavage of Polyfluoroarenes: An Efficient, Green, and Sustainable Protocol
Authors: Liu Cuibo , Zhang Bin
Published: May 2016

Review: [63 refs.
ChemInform Abstract: Artificial Water Channels — Incipient Innovative Developments
Authors: Barboiu Mihail
Published: May 2016

Review: [30 refs.
ChemInform Abstract: Ruthenium‐Amine Conjugated Organometallic Materials for Multistate Near‐IR Electrochromism and Information Storage
Authors: Tang Jian‐Hong , Yao Chang‐Jiang , Cui Bin‐Bin , Zhong Yu‐Wu
Published: May 2016

Review: [61 refs.
ChemInform Abstract: Paper Conservation Methods: A Literature Review
Authors: Zervos Spiros , Alexopoulou Irene
Published: May 2016

Review: 443 refs.
The business school scorecard: Examining the systematic sources of business school value
Authors: Finch David J. , Varella Paul , Foster William , Sundararajan Binod , Bates Kim , Nadeau John , O'Reilly Norm , Deephouse David L.
Published: May 2016

Stakeholder relationships are a critical resource that contribute to or inhibit value creation. Building on this assertion, we explore the value of the business school at a stakeholder level. We draw on research by the Canadian multistakeholder working group, the Business School Research Network (BSRN), which was established to facilitate collaborative interinstitutional research on the management and practice of business schools. We provide a conceptual model of the value chain and associated scorecard that take into account the sources of value judgments that pertain to a business school at the stakeholder‐level. Copyright © 2016 ASAC. Published by John Wiley & Sons, Ltd.
The optimization of Transparent‐Desktop service mechanism based on SPICE
Authors: Li Weimin , Wang Bin , Yu Jiaqi , Zhu Chong , Xiao Sinuo , Sheng Jinfang
Published: May 2016

Desktop virtualization, which is to make the desktop virtual so that users can access any application through the network with any devices at any time and any place, is being widely used now as an emerging trend. However, it is important to further improve this approach while maintaining good user experience. Though the simple protocol for independent computing environments as a virtual desktop solution can achieve a user experience similar to an interaction with a local machine, there are still many deficiencies in it. For instance, it cannot apply to environment of high controllability of user, and the quality of graphic interactive experience is to be improved. In this paper, to meet QoE requirements of user, we build a feasible file transfer and sharing mechanism and propose a graphics subsystem optimization strategy based on simple protocol for independent computing environments (SPICE), namely Transparent Desktop. We also verify that the Transparent Desktop can provide users with ubiquitous desktop services of higher efficiency, stronger user‐controllability and better QoE through the experimental. Copyright © 2016 John Wiley & Sons, Ltd.
Community governance in primary health care: towards an international Ideal Type
Authors: Meads Geoffrey , Russell Grant , Lees Amanda
Published: May 2016

Against a global background of increased resource management responsibilities for primary health care agencies, general medical practices, in particular, are increasingly being required to demonstrate the legitimacy of their decision making in market oriented environments. In this context a scoping review explores the potential utility for health managers in primary health care of community governance as a policy concept. The review of recent research suggests that applied learning from international health systems with enhanced approaches to public and patient involvement may contribute to meeting this requirement. Such approaches often characterise local health systems in Latin America and North West Europe where innovative models are beginning to respond effectively to the growing demands on general practice. The study design draws on documentary and secondary data analyses to identify common components of community governance from the countries in these regions, supplemented by other relevant international studies and sources where appropriate. Within a comprehensive framework of collaborative governance the components are aggregated in an Ideal Type format to provide a point of reference for possible adaptation and transferable learning across market oriented health systems. Each component is illustrated with international exemplars from recent organisational practices in primary health care. The application of community governance is considered for the particular contexts of GP led Clinical Commissioning Groups in England and Primary Health Networks in Australia. Some components of the Ideal Type possess potentially powerful negative as well as positive motivational effects, with PPI at practice levels sometimes hindering the development of effective local governance. This highlights the importance of careful and competent management of the growing resources attributed to primary health care agencies, which possess an increasingly diverse range of non‐governmental status. Future policy and research priorities are outlined. Copyright © 2016 John Wiley & Sons, Ltd.
Skewness Risk and Bond Prices
Authors: Ruge‐Murcia Francisco
Published: May 2016

This paper uses extreme value theory to study the implications of skewness risk for nominal loan contracts in a production economy. Productivity and inflation innovations are drawn from generalized extreme value distributions. The model is solved using a third‐order perturbation and estimated by the simulated method of moments. Results show that the data reject the hypothesis that innovations are drawn from normal distributions and favor instead the alternative that they are drawn from asymmetric distributions. Estimates indicate that skewness risk accounts for 12% of the risk premia and reduces bond yields by approximately 55 basis points. For a bond that pays 1 dollar at maturity, the adjustment factor associated with skewness risk ranges from 0.15 cents for a 3‐month bond to 2.05 cents for a 5‐year bond. Copyright © 2016 John Wiley & Sons, Ltd.
Curcumin Promotes Osteosarcoma Cell Death by Activating miR‐125a/ERRα Signal Pathway
Authors: Chen Peng , Wang Haibin , Yang Fan , Chen Hongwu , He Wei , Wang Junjian
Published: May 2016

Curcumin has demonstrated valuable therapeutic potential against a variety of human cancers including osteosarcoma. However, the molecular mechanisms underlying its anti‐tumor effect remain to be poorly understood. By RNA sequence profiling, we found that curcumin significantly down‐regulates the expression of estrogen‐related receptor alpha (ERRα) in osteosarcoma cells. Overexpression of ERRα diminished curcumin‐activated apoptotic cell death and scavenged curcumin‐induced reactive oxygen species (ROS), while ERRα silencing sensitized osteosarcoma cells to curcumin, resulting in increased inhibition of cell proliferation. In addition, we found that curcumin suppressed the ERRα gene expression through upregulation of miR‐125a. Data from this study revealed a novel mechanism for curcumin‐mediated apoptotic cell death, which involves tumor cell killing via activating miR‐125a/ERRα pathway. Our studies also provide further support for osteosarcoma therapy by targeting ERRα alone or in combination with curcumin. J. Cell. Biochem. 118: 74–81, 2017. © 2016 Wiley Periodicals, Inc.
Human Driving Forces of Oasis Expansion in Northwestern China During the Last Decade—A Case Study of the Heihe River Basin
Authors: Zhou Dingyang , Wang Xiaojun , Shi Minjun
Published: May 2016

Water scarcity is one of the most prominent issues worldwide in relation to sustainable development, especially in arid areas. To gain a better understanding of the trade‐off between improving agricultural productivity and maintaining the stability of an oasis ecosystem in these areas, this study took the Heihe River Basin in northwestern China as a case to explore the changes in oasis dynamics and their human driving forces. The results showed that along with the 11·0% expansion of agricultural land, the total water demand for irrigation increased by 6·3% during 2000–2010. Although tremendous economic incentives for farmers spurred the oasis expansion and cropping system changes, the key driving force behind the oasis expansion in the study area was closely related to sufficient irrigation water guaranteed by new water sources (excessive consumption of groundwater and surface water) and water conservation efforts that were the results of the “water‐saving society” project (cropping system adjustments and technological improvements in irrigation). This loose regulation of water resource management can be considered to be partially attributable to the ignorance of the ecological value of water resources. Sustainable land use in the study area can only be achieved through the strict regulation of the management of surface water and groundwater resources throughout the basin and the invisible water provided by the water conservation measures. Copyright © 2016 John Wiley & Sons, Ltd.
Homoclinic solutions for second order impulsive Hamiltonian systems with small forcing terms
Authors: Yan Lizhao , Xu Fei , Lai Mingyong
Published: May 2016

In this paper, we establish some new sufficient conditions on the existence of homoclinic solution for a class of second‐order impulsive Hamiltonian systems. By using the mountain pass theorem, we demonstrate that the limit of a 2kT‐periodic approximation solution is a homoclinic solution of our problem. We also present some examples to illustrate the applications of our main results. Copyright © 2016 John Wiley & Sons, Ltd.
A study on the convergence conditions of generalized differential transform method
Authors: Odibat Zaid M. , Kumar Sunil , Shawagfeh Nabil , Alsaedi Ahmed , Hayat Tasawar
Published: May 2016

This paper deals with constructing generalized ‘fractional’ power series representation for solutions of fractional order differential equations. We present a brief review of generalized Taylor's series and generalized differential transform methods. Then, we study the convergence of fractional power series. Our emphasis is to address the sufficient condition for convergence and to estimate the truncated error. Numerical simulations are performed to estimate maximum absolute truncated error when the generalized differential transform method is used to solve non‐linear differential equations of fractional order. The study highlights the power of the generalized differential transform method as a tool in obtaining fractional power series solutions for differential equations of fractional order. Copyright © 2016 John Wiley & Sons, Ltd.
Variational formulation of the Melan equation
Authors: Gazzola Filippo , Wang Yongda , Pavani Raffaella
Published: May 2016

The Melan beam equation modeling suspension bridges is considered. A slightly modified equation is derived by applying variational principles and by minimizing the total energy of the bridge. The equation is nonlinear and nonlocal, while the beam is hinged at the endpoints. We show that the problem always admits at least one solution whereas the uniqueness remains open although some numerical results suggest that it should hold. We also emphasize the qualitative difference with some simplified models. Copyright © 2016 John Wiley & Sons, Ltd.
Multiwavelength tunable erbium‐doped fiber laser based on Fabry–Perot filter and Mach–Zenhder interferometer
Authors: He Wei , Zhu Lianqing , Dong Mingli , Luo Fei
Published: May 2016

A tunable multiwavelength erbium‐doped ring cavity fiber laser based on a Fabry–Perot filter and Mach–Zenhder interferometer is proposed. A tunable single wavelength laser is realized from 1526.8 to 1558.6 nm, and the space interval and peak power shift are less than 2.6 nm and 0.8 dBm, respectively. A dual‐ and tunable triple‐wavelength laser are achieved, and the power fluctuation of the dual‐ and triple‐wavelength lasers is less than 0.153 and 1.28 dBm, respectively, at room temperature within a 20‐min scan time. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1790–1794, 2016
A novel reconfigurable antenna array with controllable tuning and beam steering
Authors: Katsouris Adrianos G. , Nikolopoulos Christos D. , Baklezos Anargyros T. , Capsalis Christos N.
Published: May 2016

This article describes a reconfigurable monopole liquid antenna array, suitable for wireless communications in the UHF band, focusing on obtaining and controlling notch radiation directions. Two different implementations are being studied, at the beginning three collinear monopoles placed over a ground plane and then, five monopoles over a ground plane placed in such a manner as to form a cross. By replacing the parasitic elements with cylinders filled with conductive fluids and also surrounding the driven element, it is possible it is possible to change at will the whole antenna's layout and to control both the maximum directivity angle over the azimuth and the resonant frequency, filtering interfered channels and background noise. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1782–1786, 2016
Unequal termination branch‐line balun with high‐isolation wideband characteristics
Authors: Kim Phirun , Chaudhary Girdhari , Jeong Yongchae
Published: May 2016

This article presents a design of an unequal termination impedance branch‐line balun with wideband high isolation. The wideband and high isolation characteristics are obtained only in the under‐matched region. For an experimental verification, the proposed balun was designed at a center frequency (f0) of 2.6 GHz. The measured results are in good agreement with the simulations. From the measurement, the power divisions are −3.29 dB and −3.3 dB. The return loss at f0 is 22.3 dB and is higher than 20 dB over a bandwidth of 0.51 GHz. The isolation between output ports is higher than 19 dB for the bandwidth of 0.64 GHz. The phase imbalance between two output ports is 180° ± 5° for the bandwidth of 0.64 GHz. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1775–1778, 2016
Wideband substrate‐integrated monopole antenna
Authors: Lawrence Nicholas P. , Fumeaux Christophe , Abbott Derek
Published: May 2016

A coaxial probe fed wideband low‐profile electric monopole cavity antenna with measured impedance bandwidth of 56% at a central operating frequency of 8 GHz is proposed. The antenna, based on a modified shorted square patch, effectively forms a substrate‐integrated cavity with four curved radiating slots at its periphery. The concave curvature of these four radiating slots provides a magnetic current loop mode while increasing bandwidth and reducing volume of the resonator. The proposed design may be easily fed using a 50 Ω probe feed and capacitive gap, and is robust to manufacturing tolerances, as parasitic modes are not excited. The design is compatible with applications requiring a vertically polarized signal with respect to the antenna surface. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1855–1857, 2016
Design of trisection bandpass filter based on elliptic‐function filter
Authors: Yang Yang , Cao Ke , Cheng Chong‐Hu
Published: May 2016

This article presents the design and realization of a new bandpass filter (BPF) fabricated on multilayered substrates. The proposed BPF schematic is based on the traditional elliptic‐function filter schematic. The novel schematic features a specific parallel section, which grants the new schematic the ability in reducing the undesirable value of inductors in serial arms of the conventional elliptic BPF circuit schematic. As an illustrative example, a prototype BPF with 800 MHz center frequency is designed and fabricated. The measured stop‐band rejection is better than 45 dB up to 2 GHz, and a relatively narrow bandwidth is obtained. The measured result agrees very well with the electromagnetic (EM) designed response. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1891–1894, 2016
RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long‐term survival and reveals a role forANGPTL4
Authors: Kirby Marie K. , Ramaker Ryne C. , Gertz Jason , Davis Nicholas S. , Johnston Bobbi E. , Oliver Patsy G. , Sexton Katherine C. , Greeno Edward W. , Christein John D. , Heslin Martin J. , Posey James A. , Grizzle William E. , Vickers Selwyn M. , Buchsbaum Donald J. , Cooper Sara J. , Myers Richard M.
Published: May 2016

Background

Pancreatic adenocarcinoma patients have low survival rates due to late‐stage diagnosis and high rates of cancer recurrence even after surgical resection. It is important to understand the molecular characteristics associated with survival differences in pancreatic adenocarcinoma tumors that may inform patient care.

Results

RNA sequencing was performed for 51 patient tumor tissues extracted from patients undergoing surgical resection, and expression was associated with overall survival time from diagnosis. Our analysis uncovered 323 transcripts whose expression correlates with survival time in our pancreatic patient cohort. This genomic signature was validated in an independent RNA‐seq dataset of 68 additional patients from the International Cancer Genome Consortium. We demonstrate that this transcriptional profile is largely independent of markers of cellular division and present a 19‐transcript predictive model built from a subset of the 323 transcripts that can distinguish patients with differing survival times across both the training and validation patient cohorts. We present evidence that a subset of the survival‐associated transcripts is associated with resistance to gemcitabine treatment in vitro, and reveal that reduced expression of one of the survival‐associated transcripts, Angiopoietin‐like 4, impairs growth of a gemcitabine‐resistant pancreatic cancer cell line.

Conclusions

Gene expression patterns in pancreatic adenocarcinoma tumors can distinguish patients with differing survival outcomes after undergoing surgical resection, and the survival difference could be associated with the intrinsic gemcitabine sensitivity of primary patient tumors. Thus, these transcriptional differences may impact patient care by distinguishing patients who would benefit from a non‐gemcitabine based therapy.
When Health Diplomacy Serves Foreign Policy: Use of Soft Power to Quell Conflict and Crises
Authors: Hosseini Divkolaye Nasim Sadat , Radfar Mohammad Hadi , Seighali Fariba , Burkle Frederick M.
Published: May 2016

Objective

Health diplomacy has increasingly become a crucial element in forging political neutrality and conflict resolution and the World Health Organization has strongly encouraged its use. Global turmoil has heightened, especially in the Middle East, and with it, political, religious, and cultural differences have become major reasons to incite crises.

Methods

The authors cite the example of the human stampede and the deaths of over 2000 pilgrims during the 2015 annual Haj pilgrimage in Mecca.

Results

The resulting political conflict between Iran and Saudi Arabia had the potential to escalate into a more severe political and military crisis had it not been for the ministers of health from both countries successfully exercising “soft power” options.

Conclusion

Global health security demands critical health diplomacy skills and training for all health providers. (Disaster Med Public Health Preparedness. 2016;page 1 of 4)
Reply to the Editorial
Authors: Ossip Deborah J.
Published: May 2016

The Associate Editor for this themed issue (Deborah Ossip) also wishes to express her appreciation on behalf of the Journal of Smoking Cessation to Dr Kenneth Ward for his outstanding job as Guest Editor to provide this compendium of lessons learned from LMICs around the globe regarding tobacco cessation research.
Microstructural characterisation of the Ypresian clays (Kallo-1) at nanometre resolution, using broad-ion beam milling and scanning electron microscopy
Authors: Hemes S. , Desbois G. , Klaver J. , Urai J.L.
Published: May 2016

Besides the Oligocene Boom Clay, the Ypresian clays – part of the Eocene Ieper Group (Kortrijk Formation and Kortemark Member) – are currently being investigated as an alternative host rock for the deep geological disposal of radioactive waste in Belgium and the Netherlands. In this study, broad-ion-beam milling and high resolution scanning electron microscopy (BIB-SEM) analyses were carried out to analyse the mineral fabrics and microstructures of representative Ypresian clay samples from different depths of the ON-Kallo-1 borehole (Kallo, Belgium). Qualitative microstructural observations indicate that mineral fabrics and pore morphologies in fine-grained samples are comparable to those found for fine-grained Boom Clay, but most of the Ypresian clay samples analysed also contained a significant silt fraction, which is associated with larger inter-aggregate pores, coated by a thin, very low porous clay layer. Quantitative pore-shape analysis shows lower axial ratios and elongations, as well as higher roundness and circularities for pores in the clay matrix of the more coarse-grained samples, compared to the fine-grained samples. The contribution of large pores (>1 × 107nm² pore area) to the total BIB-SEM observed porosity was found to correlate with the non-clay mineral (NCM) content of a sample. Frequencies of pore sizes within the clay matrix follow a power-law distribution, hinting towards the possibility of up-scaling of the nanometre-scale observations to larger scale (micro-) structural features of the material. Power-law exponents are comparable to values found for power-law pore-size distributions within the clay matrix of the Boom Clay, which indicates similarity of the pore-space morphologies within the clay matrix of the Boom Clay and the Ypresian clays. Wood's metal injection, followed by (cooled BIB)-SEM analysis shows that all visible pores are connected via pore throats of diameter down to ~10 nm.
‘Aesop’, ‘Q’ and ‘Luke’
Authors: Reece Steve
Published: May 2016

The last chapter of the gospel of Luke includes a story of the risen Christ meeting two of his disciples on their way from Jerusalem to the village of Emmaus and chastising them with the poetic expression ὦ ἀνόητοι καὶ βραδεῖς τῇ καρδίᾳ ‘O foolish ones, and slow in heart’ (Luke 24.25). No commentator has ever observed that Jesus' expression occurs verbatim, in the same iambic trimeter metre, in two poetic versions of animal fables attributed to the famous Greek fabulist Aesop. It is plausible that Luke is here, as at least twice elsewhere in his gospel, tapping into the rich tradition of Aesopic fables and proverbs that were widely known throughout the Mediterranean world in the first century ce.
PGE2 maintains self-renewal of human adult stem cells via EP2-mediated autocrine signaling and its production is regulated by cell-to-cell contact
Authors: Lee Byung-Chul , Kim Hyung-Sik , Shin Tae-Hoon , Kang Insung , Lee Jin Young , Kim Jae-Jun , Kang Hyun Kyoung , Seo Yoojin , Lee Seunghee , Yu Kyung-Rok , Choi Soon Won , Kang Kyung-Sun
Published: May 2016

Mesenchymal stem cells (MSCs) possess unique immunomodulatory abilities. Many studies have elucidated the clinical efficacy and underlying mechanisms of MSCs in immune disorders. Although immunoregulatory factors, such as Prostaglandin E2 (PGE2) and their mechanisms of action on immune cells have been revealed, their effects on MSCs and regulation of their production by the culture environment are less clear. Therefore, we investigated the autocrine effect of PGE2 on human adult stem cells from cord blood or adipose tissue and the regulation of its production by cell-to-cell contact, followed by the determination of its immunomodulatory properties. MSCs were treated with specific inhibitors to suppress PGE2 secretion and proliferation was assessed. PGE2 exerted an autocrine regulatory function in MSCs by triggering E-Prostanoid (EP) 2 receptor. Inhibiting PGE2 production led to growth arrest, whereas addition of MSC-derived PGE2 restored proliferation. The level of PGE2 production from an equivalent number of MSCs was down-regulated via gap junctional intercellular communication. This cell contact-mediated decrease in PGE2 secretion down-regulated the suppressive effect of MSCs on immune cells. In conclusion, PGE2 produced by MSCs contributes to maintenance of self-renewal capacity through EP2 in an autocrine manner and PGE2 secretion is down-regulated by cell-to-cell contact, attenuating its immunomodulatory potency.
A melanosomal two-pore sodium channel regulates pigmentation
Authors: Bellono Nicholas W. , Escobar Iliana E. , Oancea Elena
Published: May 2016

Intracellular organelles mediate complex cellular functions that often require ion transport across their membranes. Melanosomes are organelles responsible for the synthesis of the major mammalian pigment melanin. Defects in melanin synthesis result in pigmentation defects, visual deficits, and increased susceptibility to skin and eye cancers. Although genes encoding putative melanosomal ion transporters have been identified as key regulators of melanin synthesis, melanosome ion transport and its contribution to pigmentation remain poorly understood. Here we identify two-pore channel 2 (TPC2) as the first reported melanosomal cation conductance by directly patch-clamping skin and eye melanosomes. TPC2 has been implicated in human pigmentation and melanoma, but the molecular mechanism mediating this function was entirely unknown. We demonstrate that the vesicular signaling lipid phosphatidylinositol bisphosphate PI(3,5)P2 modulates TPC2 activity to control melanosomal membrane potential, pH, and regulate pigmentation.
MgZnO/ZnO heterostructures with electron mobility exceeding 1 × 106 cm2/Vs
Authors: Falson Joseph , Kozuka Yusuke , Uchida Masaki , Smet Jurgen H. , Arima Taka-hisa , Tsukazaki Atsushi , Kawasaki Masashi
Published: May 2016

The inherently complex chemical and crystallographic nature of oxide materials has suppressed the purities achievable in laboratory environments, obscuring the rich physical degrees of freedom these systems host. In this manuscript we provide a systematic approach to defect identification and management in oxide molecular beam epitaxy grown MgZnO/ZnO heterostructures which host two-dimensional electron systems. We achieve samples displaying electron mobilities in excess of 1 × 106 cm2/Vs. This data set for the MgZnO/ZnO system firmly establishes that the crystalline quality has become comparable to traditional semiconductor materials.
NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance
Authors: Li Shengbing , Wang Cong , Li Ke , Li Ling , Tian Mingyuan , Xie Jing , Yang Mengliu , Jia Yanjun , He Junying , Gao Lin , Boden Guenther , Liu Hua , Yang Gangyi
Published: May 2016

NAMPT has been suggested association with atherosclerosis and insulin resistance. However, the impact of NAMPT on atherosclerosis remained unknown. Therefore, the objective of this study was to use a NAMPT loss-of-function approach to investigate the effect of NAMPT on atherosclerosis in hypercholesterolemic mice. We demonstrated that a specific NAMPT knockdown increased plasma HDL-C levels, reduced the plaque area of the total aorta en face and the cross-sectional aortic sinus, decreased macrophage number and apoptosis and promoted RCT in HFD-fed ApoE KO mice. These changes were accompanied by increased PPARα, LXRα, ABCA1 and ABCG1 expressions in the liver. NAMPT knockdown also facilitated cholesterol efflux in RAW264.7 cells. We further investigated the effect of NAMPT knockdown on the PPARα-LXRα pathway of cholesterol metabolism with MK886 (a selective inhibitor of PPARα) in RAW264.7 macrophages. MK886 abolished the ability of NAMPT knockdown to decrease intracellular cholesterol levels to enhance the rate of 3H-cholesterol efflux and to increase ABCA1/G1 and LXRα expressions in RAW264.7 macrophages. Our observations demonstrate that NAMPT knockdown exerted antiatherogenic effects by promoting cholesterol efflux and macrophage RCT through the PPARα- LXRα- ABCA1/G1pathway in vitro and in vivo.