bluuebunny/crossref_metadata_2025 huggingface dataset:
WITHDRAWN: Membrane Stabilization and Vascular Permeability as
Mechanisms for the Evaluation of Anti-inflammatory Action of Omega-3-
poly Unsaturated Fatty Acid Oil Extract
Authors: J. A Omale, , L. U. S Ezeanyika, , A Omale,
Published: May 2023

Method:

Animals were distributed in six groups of five each (n = 5). Group 1 was administered 300mg/ml omega-3 fatty acids (n-3 FA) containing 180mg/ml EPA and 120mg/ml DHA; group 2 received 600mg/ml n-3 FA containing 360mg/ml EPA and 240mg/ml DHA; group 3 received 900mg/ml n-3 FA containing 540mg/ml EPA and 360mg/ml DHA; group 4 was administered 300mg/ml of the fish oil along with 20mg/ml celecoxib; group 5 was given 20mg/ml celecoxib that represented the positive control, and group 6 was administered 2 ml phosphate buffer saline alone, which served as the vehicle control group. Membrane stabilization of the rat’s red blood cells and aceticacid-induced vascular permeability were assayed. The percentage inhibition was determined. The analysis was performed using GraphPad InStat version 5 software and subjected to the Bonferroni test for the separation of means.
“Male’s Perception About Menstruation, it’s Associated Problems and
Menstrual Hygiene in their Female Partners: A Qualitative Study”
Authors: Kumar Naina , Kottu Divya Satya Sree , Katta Pravalika , Mangla Mishu , Kartik Medapati
Published: May 2023

Aim:

Present study was conducted to assess the knowledge and perception of men about
menstruation and it’s associated problems in their female partners.

Background:

Menstruation is considered a social stigma in many low- and middle-income countries.

Objectives:

To assess men’s attitudes, beliefs, understandings, and knowledge about menstruation.

Methods:

The study involved interviews of 80 male partners of females attending the Obstetrics and
Gynaecology Department of the rural tertiary center of Southern India for various complaints over one
year. Data obtained was analyzed using thematic analysis. Four themes with sub-themes reflecting
responses to key questions were formed: men’s perception and knowledge about menstruation,
cultural and societal issues, men’s observation and attitude towards their wives during menstruation,
and the father’s role in generating awareness.

Results:

Of 80 participants, 92.5% were comfortable, 6.25% uncomfortable and 1.25% were not
sure about the interview. Their feelings about menstruation varied from nothing, disgusting/bad, to
normal. Men’s knowledge about menstruation was restricted and the majority were hesitant to
discuss it. Almost everyone was aware of cultural taboos being followed at home, with most
responses revealing menstruating women as untouchable/impure. Men observed changes in mood,
sleep, and sexual desire of their partners before and during menstruation. The majority wanted their
children to know about menstruation, but they don’t want to teach. Overall feedback about the interview
was positive.

Conclusion:

Ignorance and secrecy related to menstruation, stop men from understanding the problems
faced by women. Educating boys about menstruation and menstrual hygiene is the only way to
uproot the long-standing stigma attached to menstruation.
Public Reproductive Health Concerns Related to the COVID-19 Vaccination:
A Retrospective Analysis of Google Trends Data in Iran
Authors: Azmoude Elham , larki Mona , Marvi Nahid , Roudsari Robab Latifnejad
Published: May 2023

Background:

Vaccination is known as the safest and the most effective method to control
the COVID-19 pandemic. However, the spread of misconceptions is one of the causes of vaccination
hesitancy worldwide. Google is one of the most popular databases used by people to search for answers to their health concerns

Objective:

This study aimed to identify the most public reproductive health concerns in relation to the
COVID-19 vaccination of Iranians using data obtained from Google Trends.

Methods:

In this infodemiology study, the data were retrieved from Google Trends regarding the most
public reproductive health concerns of COVID-19 vaccination using search terms "abortion", ‘infertility’, ‘menstruation’, ‘pregnancy’ and ‘sexuality’ in combination with "COVID-19 vaccine" in Iran.
The period chosen was from February 1, 2021, to December 31, 2022. The relative search volumes
(RSV) of the search terms were compared

Results:

The comparison of the top five searched terms showed that the combination of the terms
"pregnancy" and "Corona vaccine" had the highest popularity. The combination of search terms "sexuality","abortion","menstruation", and"infertility" with the "Corona vaccine" was the next in the
search rankings, respectively. The search interest increased after July 2020, and peaked in August and
September 2021, when the vaccination of pregnant women was announced. From December 2021, the
search interest decreased with a generally slow slope across all curves. The search interests differed
among the 31 provinces of Iran

Conclusion:

Public health authorities can use this study to better understand the reproductive health
concerns of the community regarding COVID-19 vaccination. They can then apply this data for health
planning, setting up agendas, and policy making.
Pedunculated Angiomyofibroblastoma of Labia Minora: A Case Report
and Review of the Literature
Authors: Bharti Jyotsna Naresh , Nigam Jitendra Singh
Published: May 2023

Background:

Angiomyofibroblastoma was first described by Fletcher et al. in the year
1992. It is a distinctive benign tumor that most often occurs in the superficial area of the vulva and is
rarely reported in men in the inguinoscrotal region.

Case Presentation:

A 23-year-old female presented with a painless pedunculated labial mass which
was initially pea-sized and reached 7 cm in maximum dimension over four months. The case was diagnosed
on morphology, IHC and the patient was treated surgically. The interesting feature of the case
was the rarity of its incidence at labia minora and pedunculated form and its resemblance to other benign
and more aggressive tumours. To the best of our knowledge, the extensive English literature
search revealed only seven cases of pedunculated angiomyofibroblastoma at labia majora in middleaged
female and one case of labia minora in a young female.

Conclusion:

The lesion must be differentiated from another benign mesenchymal tumor of vulva
which requires extensive surgical management.
Recent Developments in Combinatorial Immunotherapy towards Ovarian
Cancer
Authors: Jain Chakresh Kumar , Kulshreshtha Aishani , Saxena Harshita , Agarwal Avinav , Passi Kalpdrum
Published: May 2023

Ovarian cancer is one of the most common cancers in women in the world. It is also the 5th
top cause of cancer-related death in the world. Despite chemotherapy being the primary treatment
along with surgery, patients frequently suffer from a recurrence of ovarian cancer within a few years
of the original treatment. The recurring nature of OC, therefore, necessitates the development of novel
therapeutic interventions that can effectively tackle this disease. Immunotherapy has lately been found
to offer significant clinical advantages. Some of the immunotherapy techniques being studied for ovarian
cancer include adoptive T-cell treatment, immune checkpoint inhibition, and oncolytic virus.
However, the most efficient way to increase longevity is through a combination of immunotherapy
strategies with other disease therapeutic approaches such as radiotherapy, chemotherapy, and PARPi
in additive or synergistic ways. To provide a more comprehensive insight into the current immunotherapies
explored, this paper explores newly developed therapeutics for the disease with an emphasis
on current outstanding immunotherapy. The current state of our understanding of how the disease interacts
with host cells, current therapy options available, various advanced treatments present and the
potential for combinatorial immuno-based therapies in the future have also been explored.
Review on Determination of Berberine in Biological and Pharmaceutical
Matrices: An Analytical and Therapeutic Perspective
Authors: Shah Umang , Patel Meghana , Patel Alkesh , Patel Krishna , Patel Mehul , Akabari Ashok , Patel Samir , Patel Veena , Maheshwari Rajesh , Sen Ashim , Sethiya Neeraj Kumar
Published: May 2023

Berberine (BRB) is a natural alkaloid of the isoquinoline class, mostly isolated from the
Berberis genus, which exhibits antibiotic, immunostimulant, antitumor, cardiovascular protection, endocrine
regulator, antidepressant, neuroprotective, antioxidant, anti-inflammatory, and other pharmacological
properties. The poor aqueous solubility of BRB is one roadblock in scaling up activities for
the clinical drug. However, this can be overcome by its chemical modification into salt form. Extraction
of this biologically beneficial component becomes one of the important aspects, and for that, several
extraction techniques are available using a variety of solvents. Numerous analytical methods are
reported for the quantification of extracted BRB as well as simultaneous estimation of BRB in the
presence of other components. Among them, RP-HPLC, LC/MS, and UPLC/MS are the most frequently
used methods. The effectiveness and preciseness of these advanced methods could be the reason
for analysts’ preferred choice for analysis.
Paracetamol (Acetaminophen)-associated SJS, TEN, AGEP, and DRESS
Syndromes - A Narrative Review
Authors: Pakkir Maideen Naina Mohamed , Barakat Ibrahim Ramadan , Jumale AbduRazak Hassan
Published: May 2023

Introduction:

Paracetamol (Acetaminophen) is a very common OTC drug that is found
in more than 200 OTC products sold as pain, cough and cold remedies. Paracetamol is commonly
used as an antipyretic to reduce fever and as an alternative to Non-steroidal anti-inflammatory
drugs (NSAIDs) that are contraindicated in certain patients to relieve mild-moderate pain.

Objective:

This review article focuses on SJS, TEN, SJS/TEN overlap, AGEP, and DRESS syndromes
associated with the use of paracetamol or paracetamol-containing products.

Methods:

To find published articles relevant to paracetamol-associated SJS, TEN, AGEP, and
DRESS, we searched the online databases Medline/Pubmed/PMC, Google Scholar, Science Direct,
Ebsco, Scopus, Web of Science, Embase, and reference lists using keywords like Stevens-Johnson
Syndrome, Acetaminophen, Paracetamol, Toxic epidermal necrolysis, Acute generalized exanthematous
pustulosis, Drug reaction with eosinophilia and systemic symptoms.

Results:

The paracetamol-associated SJS, TEN, SJS/TEN overlap, AGEP, and DRESS syndromes
have been identified by a number of publications.

Conclusion:

When evaluating drug-induced hypersensitivity skin reactions, healthcare professionals,
including prescribers, pharmacists, and others, should be aware of this rare risk. Patients who
exhibit signs and symptoms of paracetamol-associated hypersensitivity should be referred to physicians
by pharmacists for further treatment. At the first sign of a skin rash or other hypersensitivity
reaction while taking paracetamol, patients should be told to stop taking it and see a doctor right
away.
Differentiation of Pancreatic Beta Cells: Dual Acting of Inflammatory Factors
Authors: Shahedi Faeze , Munggela Foma Arron , Mahmoudi-Aznaveh Azam , Mazlomi Mohammad Ali , Azizi Zahra , Khorramizadeh Mohammad Reza
Published: May 2023

In the past decades, scientists have made outstanding efforts to treat diabetes. However, diabetes
treatment is still far from satisfactory due to the complex nature of the disease and the challenges encountered
in resolving it. Inflammatory factors are key regulators of the immune system's response to
pathological insults, organ neogenesis, rejuvenation of novel cells to replace injured cells and overwhelming
disease conditions. Currently, the available treatments for type 1 diabetes include daily insulin injection,
pancreatic beta cell or tissue transplantation, and gene therapy. Cell therapy, exploiting differentiation,
and reprogramming various types of cells to generate pancreatic insulin-producing cells are novel
approaches for the treatment of type 1 diabetes. A better understanding of the inflammatory pathways
offers valuable and improved therapeutic options to provide more advanced and better treatments for
diabetes. In this review, we investigated different types of inflammatory factors that participate in the
pathogenesis of type 1 diabetes, their possible dual impacts on the differentiation, reprogramming, and
fusion of other stem cell lines into pancreatic insulin-producing beta cells, and the possibility of applying
these factors to improve the treatment of this disease.
Exosome-mediated Repair of Intervertebral Disc Degeneration: The
Potential Role of miRNAs
Authors: Wang Han-Shi , Lin Shu , Yu Hai-Ming
Published: May 2023

Intervertebral disc degeneration (IVDD) is a serious condition that manifests as low back pain,
intervertebral disc protrusion, and spinal canal stenosis. At present, the main treatment methods for IVDD
are surgical interventions such as discectomy, total disc replacement, and spinal fusion. However, these
interventions have shown limitations, such as recurrent lumbar disc herniation after discectomy, lesions in
adjacent segments, and failure of fixation. To overcome these shortcomings, researchers have been exploring
stem cell transplantation therapy, such as mesenchymal stem cell (MSC) transplantation, but the
treatment results are still controversial. Therefore, researchers are in search of new methods that are more
efficient and have better outcomes. The exosomes from stem cells contain a variety of bioactive molecules
that mediate cell interactions, and these components have been investigated for their potential therapeutic
role in the repair of various tissue injuries. Recent studies have shown that MSC-derived miRNAs
in exosomes and vesicles have therapeutic effects on nucleus pulposus cells, annulus fibrosus, and cartilage
endplate. miRNAs play a role in many cell activities, such as cell proliferation, apoptosis, and cytokine
release, by acting on mRNA translation, and they may have immense therapeutic potential, especially
when combined with stem cell therapy. This article reviews the current status of research on intervertebral
disc repair, especially with regard to the latest research findings on the molecular biological mechanisms
of miRNAs in MSC-derived exosomes in intervertebral disc repair.
Design of Novel Imidazopyrazine Derivative against Breast Cancer via Targeted
NPY1R Antagonist
Authors: Niranjan Vidya , R Vibha , Philip Sarah , Uttarkar Akshay , Kusanur Raviraj , Kumar Jitendra
Published: May 2023

Introduction:

Breast cancer is the most frequent malignancy in women with more than one in ten new cancer
diagnoses each year. Synthetic products are a key source for the identification of new anticancer medicines and
drug leads.

Objectives:

Imidazopyrazine is a highly favored skeleton for the design of new anticancer drugs. In silico designed
derivatives were screened using computer aided drug design techniques and validated using MTT assay.

Methods:

A template-based methodology was used in the current work to create novel Imidazopyrazine derivatives,
targeting the NPY1R protein. Molecular docking, Diffusion docking, MD simulation, MM-GBSA and meta-dynamics
techniques were followed. MTT assay was performed to validate the activity of principal compound.

Results:

A docking score of -6.660 and MMGBSA value of -108.008 (+/-) 9.14 kcal/mol was obtained from the investigations
conducted. In addition, molecular dynamics simulation was carried out for 500 ns, yielding a stable RMSD
and value of 5.6 Å, thus providing insights on the stability of the protein conformation on interaction with the principal
compound. Furthermore, the in vivo validation studies conducted via MTT assay showed an IC50 value of 73.45 (+/-)
0.45 μg /mL.

Conclusion:

The research has produced encouraging findings and can be applied as a model for precise enumerations
in the future. It also encourages the study of novel synthetic compounds with potential anti-cancer properties.
Primary Cutaneous Mucormycosis: A Necrotising Soft Tissue Infection
with Poor Prognosis
Authors: Dogra Poornima , Singla Nidhi , Kaushik Robin , Singh Simrandeep , Gupta Varsha
Published: May 2023

Background:

Cutaneous mucormycosis is an unusual fungal infection that continues to
occur. It needs aggressive surgical debridement and timely administration of antifungals due to its high
fatality rate. High clinical suspicion on the part of a surgeon is required to prevent the same.

Case Presentation:

We present two cases of cutaneous mucormycosis in which the patients succumbed
to death, highlighting the seriousness of the condition. One patient had a lower leg ulcer and was diabetic,
and the other patient had a gluteal abscess following an intramuscular injection. Tissue samples
grew Rhizopus arrhizus and Apophysomyces sp., respectively. Both patients were treated with amphotericin
B, and extensive debridement was performed.

Discussion:

Cutaneous mucormycosis can be reported in immunocompetent people, and there is a
need for early recognition of the entity as a differential diagnosis of any nonhealing necrotic ulcer.

Conclusion:

Proper training and education of technical and clinical staff should be done at peripheral
primary and secondary care centres so as not to miss out on cases of mucormycosis and for better
prognosis in a cutaneous variety of mucormycosis in surgical patients.
miRNA-363-3p Hinders Proliferation, Migration, Invasion and Autophagy of
Thyroid Cancer Cells by Controlling SYT1 Transcription to affect NF-κB
Authors: Zhang Jizong , Ren Guanghui , Huang Tao , Sang Yiming , Zhong Yan , Yi Yongxiang
Published: May 2023

Background:

Thyroid cancer (TC) is a frequent endocrine malignant tumor with various pathologic types. miRNA-363-3p plays a pivotal part in the occurrence, development, prognosis, and treatment of cancer.

Objective:

To explore the mechanism of miRNA-363-3p in TC and provide a new idea for targeted therapy of TC.

Methods:

Differential miRNAs and downstream target mRNAs in TC tissues were predicted with bioinformatics analysis. Expression levels of miRNA-363-3p and Synaptotagmin I (SYT1) in TC cells were ascertained by qRT-PCR. Cell migration, invasion, and proliferation were detected by wound healing assay, transwell assay, colony formation assay, CCK-8, and BrdU fluorescence ex-periment, respectively. Flow cytometry was utilized to detect the levels of apoptosis and necrosis. Immunofluorescence assay was used for detecting autophagosome formation in cells, and the ex-pression levels of autophagy-related proteins, as well as NF-κB related proteins, were measured by western blot. Dual-luciferase reporter gene assay was applied for detecting the interaction between miRNA-363-3p and SYT1.

Results:

miRNA-363-3p was prominently down-regulated in TC cells. miRNA-363-3p overexpres-sion suppressed migration, invasion, and proliferation, promoting apoptosis and necrosis of TC cells. As the downstream target of miRNA-363-3p, SYT1 was up-regulated in TC cells. SYT1 overexpression reversed the inhibition of TC cell proliferation, invasion, migration, and autophagy mediated by miRNA-363-3p overexpression. In addition, miRNA-363-3p overexpression inhibited the activation of the NF-κB pathway in cells, while further overexpression of SYT1 weakened the inhibition of miRNA-363-3p overexpression on the NF-κB pathway.

Conclusion:

miRNA-363-3p affected the NF-κB signaling pathway by down-regulating SYT1 ex-pression to inhibit the malignant progression of TC cells, providing theoretical support for the treat-ment of TC.
Growth Hormone Treatment in Children with Perthes Disease and Growth
Hormone Deficiency: A Case Report and Literature Review
Authors: Shi Yuzhen , Ying Yanqin , Luo Xiaoping , Hou Ling
Published: May 2023

Background:

Perthes disease is an idiopathic femoral head necrosis disease in children. Although it is believed that the prognosis after surgery within 5 years of age is good, there are very few reports in the literature regarding concurrent growth hormone deficiency and the outcome of growth hormone treatment. We retrospectively analyzed and summarized the clinical data of pa-tients with Perthes disease and GHD in a child treated with rhGH for four years.

Case report:

We reported the case of an 11.9-year-old boy diagnosed with “Perthes disease” at 2.7 years. He underwent surgery at the age of 4.8 years and recovered well. At 6.7 years old, he was admitted for “slow growth in height for more than four years.” Physical examination demon-strated severe short stature with a height of 108.8 cm (< 3rd percentile, -2.45 standard deviation (SD)). The major abnormalities observed in the auxiliary examinations included low insulin-like growth factor-1 (IGF-1) (-1.73SD) and low GH peak levels (< 5 μg/L) in the growth hormone stim-ulation test. A diagnosis of complete GHD was confirmed, and low-dose rhGH treatment was ad-ministered. After four years of rhGH treatment, his height reached 152.3 cm (50th-75th percentile, + 0.29 SD). The annual growth rate was approximately 9.1 cm per year, and the curative effect was significant. No adverse reactions were observed during the treatment.

Conclusion:

The benefits of rhGH in children with Perthes disease and GHD may outweigh its risks. However, its safety requires long-term follow-up evaluation.
Bone Marrow as a Therapeutic Target for Type 2 Diabetes Complications
Authors: Cifuentes-Mendiola Saúl Ernesto , Baiza-Gutman Luis Arturo , García-Hernández Ana Lilia
Published: May 2023

Type 2 diabetes mellitus (T2DM) is a world epidemic with a high prevalence and mor-tality. The origin of macro and microvascular complications associated with T2DM is complex and new mechanisms to explain their development are emerging. The changes induced by T2DM in the microenvironment of bone marrow (BM) alter the expansion and differentiation of stem cells and have been related to the development of micro and macrovascular diseases. Alterations in the differentiation and function of hematopoietic, endothelial, and mesenchymal stem cells in T2DM patients reduced the mobility of BM stem cells to the circulation and some immature, dysfunc-tional, or inflammatory cells pass to the blood (mobilopathy). Consequently, tissue repair is im-paired, and the tissue damage caused by hyperglycemia, oxidative stress, and inflammation is in-creased. These alterations can contribute to diabetic complications, decreasing the quality of life, and increasing mortality. The modulation of the bone marrow microenvironment may be a therapeu-tic target for treating T2DM and its complications. This article analyses the changes induced in BM and their impact on the development of cardiovascular and kidney complications in T2DM. Also, different therapeutic strategies to restore the bone marrow microenvironment and function through the modulation of oxidative stress, inflammation, and adipogenicity are discussed, considering bone marrow as a novel potential therapeutic target to treat vascular complications of diabetes.
Research Progress and Prospect on Profile Roll Forming Methods and
Equipment
Authors: Jing Yigang , Sun Qun , Zhao Ying
Published: May 2023

In recent years, with the development of aerospace, automotive, rolling stock, shipbuilding,
military weapons and other industries, the demand for bent and rolled parts is increasing, and
the requirements for roll forming accuracy are growing. With the rapid development of coal power,
hydropower, nuclear power, wind power, and petrochemical industries, the design and research on
roll bending machine and the profile roll forming methods have come into focus. The purpose of
this study is to summarize the classification and characteristics of roll bending equipment, analyze
the reasons that affect the accuracy of profile bending, and propose specific solutions. This paper
summarizes the research status and patents on the existing roll bending equipment, introduces its
structural characteristics, differences, and molding effects, and focuses on the difficulties, optimization,
and improvement methods of roll bending molding. In this paper, the mechanical structures
of the existing roll forming equipment have been analyzed and compared, the effects of different
roll forming equipment on the profile bending results have been determined, and the reasons affecting
the bending accuracy have been pointed out. By summarizing the patents and research on profile
roll forming methods and equipment, the current situation and future research prospects of roll
forming equipment are discussed. The roll forming equipment is divided into a roll bending machine,
a CNC roll bending machine, and a flexible roll bending machine. Each design can meet different
profile processing needs. From the design point of view, the optimization under the given
processing profile can achieve relatively high processing accuracy. However, the processing of different
profiles will still produce geometric defects, and there is some space for improvement in the
structure of roll forming equipment, the materials of processing rollers, and the NC interactive system.
Thus, further research on profile roll forming is needed in the future.
Targeted Approach to Enhance the Solubility of Weakly Soluble Drugs by
Nanocrystal Technology
Authors: Rana Sangam , Tomar Deepali , Kaushik Peeyush , Sharma Prerna , Rani Nidhi , Guarve Kumar
Published: May 2023

About 90% of the newly discovered drugs are poorly soluble in water, to overcome this problem,
nanocrystal technology is used. Nanocrystal technology is a modern technique that is specially
used to increase the solubility of less soluble drugs. Production of a nanocrystal on a large scale can be
done by techniques like homogenization (high-pressure), precipitation, and milling methods. Using this
technique, saturation solubility, the adhesiveness of a drug molecule to the surface cell, and the dissolution
velocity is enhanced. This technology is better than the traditional method because it provides certain
other benefits like increased drug loading capability, fantastic reproducibility of oral retention, further
developed proportionality of portion bioavailability and expanded patient compliance. This audit
makes sense of the various kinds of techniques for the arrangement of nanocrystals, benefits, drawbacks,
a system of solvency improvement, clinical applications, and future imminent. This review article
also provides further guidelines for studies about nanocrystal technology.
Preparation of Folic acid@Arsenic Nanoparticles and Evaluation of their
Antioxidant Properties and Cytotoxic Effects
Authors: Shakibaie Mojtaba , Faraji Maryam , Ranjbar Mehdi , Adeli-Sardou Mahboubeh , Jabari-Morouei Fereshteh , Forootanfar Hamid
Published: May 2023

Introduction::

In this study, arsenic nanoparticles containing folic acid (FA@As NPs) were
synthesized by microwave irradiating a mixture of As2O3 and sodium borohydride solution in the presence
of folic acid.

Methods::

The physicochemical characteristics of the prepared NPs were studied by UV–visible spectroscopy,
transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), X-ray
diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) analyses. Antioxidant activities,
hemocompatibility, and cytotoxic effects of the prepared NPs were then evaluated. The attained results
showed that the hexagonal FA@As NPs have a size range between 12.8 nm and 19.5 nm.

Results::

The DPPH scavenging activity of FA@As NPs was found to be significantly greater than that
of As NPs at concentrations ranging from 40 μg/mL to 2560 μg/mL (p<0.05). The hemolytic test confirmed
that the measured hemolysis percentage (HP) for FA@As NPs and As NPs was 0% at concentrations
between 20 to160 μg/mL, and for FA@As NPs, the measured HP was not significantly higher than
As NPs at concentrations higher than 320 μg/mL (p>0.05).

Discussion::

The necessary concentration for the death of half of the cells (IC50) for MDA-MB-231,
MCF-7, and HUVEC cells treated (24 h) with FA@As NPs was measured to be 19.1±1.3 μg/mL,
15.4±1.1 μg/mL, and 16.8±1.2 μg/mL, respectively. However, further investigations are necessary to
clarify the mechanisms behind the biological activities of FA@As NPs.
An Analytical Method for Determination of Total Iron in Pharmaceuticalgrade
Intravenous Iron Colloidal Complexes by Redox-Potentiometry
Authors: Kamisetty Madhava Krishna , Medisetty Rajesh , Ramesh Bandla , Pappureddy Suresh , Kashanna Jajula , Govinda Varadhi , Kishore Ravada
Published: May 2023

Background:

Iron carbohydrate complexes are colloidal dispersions made up of polynuclear
Fe(III)-oxyhydroxide cores surrounded by a carbohydrate shell that stabilizes the complex in iron colloidal
formulations. The current study provides an improved method that is precise, accurate, and linear
for quantifying total iron in most Iron Carbohydrate Colloid Drug Products.

Methods:

Redox iodometry with a potentiometric determination is used to evaluate total iron in intravenous
formulations. The visual indicator approach is more prone to fluctuations at endpoint calculations.
Hence, the voltage potential approach is widely accepted as it is more accurate and sensitive. It tracks
the actual change in activity that coincides with the equivalence point that is finally considered an endpoint.
The principle is based on the idea that ferric iron in formulation reduces to ferrous iron in the
presence of the iodide, which oxidizes to iodine. The released iodine is titrated using sodium thiosulfate.

Results:

The proposed method was precise, with %RSD (relative standard deviation) not more than 1.
The method was linear between 80% and 120%, with a linear regression of 0.999. The percent recovery
ranged from 98.20 to 99.98 for the concentration ranges of 80-120. The method's robustness was
checked by various analysts using different reagent grades.

Conclusion:

The proposed potentiometric determination method was precise, accurate, linear, and sensitive.
The method was successfully validated, and the total iron content determined for commercial
batches agrees with the iron claim on the label. Therefore, this method can be adapted widely for total
iron content determination in any Intravenous formulation currently available on the market. The proposed
method is more accessible at the Quality Control facilities on an industrial scale.
Concept of Fasting Therapy in the Traditional Indian Medicine of Ayurveda
Authors: Kumar Syal , Rampp Thomas
Published: May 2023

Ayurveda is a traditional Indian medical practice, which has at its heart a subcontinent
filled with diverse customs and ethos. Since ancient times, as considered in the Vedas, fasting has
been considered to aid a man’s spiritual life as a means of purification. The body and mind constitute
the substrata of diseases, and the imbalance of Vata, Pitta, Kapha, somatic Doshas, and Rajas
and Tamas (mental doshas) results in various diseases. Derangement of metabolism (Agni) is a major
cause of the imbalance in the abovementioned doshas. In Ayurveda, Agni refers to the complete
process of metabolic activities, both at the levels of the gastrointestinal tract (GIT) and the tissues.
Digestion, metabolism, and assimilation, that is, the entire process of biological conversion and utilisation,
is symbolised by ‘Agni’. The concept of channels and microchannels (srotus) plays a major
role in metabolic processes as particles are transported for various bodily functions through these
channels.

:

The concept of metabolic toxins (Ama) is very relevant in modern times, particularly in the treatment
of many diseases including irritable bowel syndrome, ulcerative colitis, adiposity, hypercholesterolaemia,
obesity, diabetes, rheumatoid arthritis, fibromyalgia, oedema, migraine, chronic fatigue
syndrome, burnout syndrome, various skin diseases and psychiatric and psychosomatic diseases
that occur due to weak digestion and tissue metabolism. The vitiated doshas in the body, particularly
in the stomach, reduce the intensity of or impair digestive activity to cause digestive impairment
and the production of metabolic toxins. They together block the channels in the body
which result in various diseases. Fasting is the absence of food in the viscera or ensuring a controlled
food intake and aids the digestion of metabolic toxins, kindles digestive enzymes, activates
tissue metabolism, and removes the blockage in the channels.
APT Attack Detection of a New Power System based on DPI-transformer
Authors: Zhang Yazhuo , Li Yuancheng
Published: May 2023

Introduction:

In recent years, the frequent occurrence of network security attacks in the power field has brought huge risks to the production, transmission, and supply of power systems, and Advanced Persistent Threat (APT) is a covert advanced network security attack, which has become one of the network security risks that cannot be ignored in the construction of new power systems.

Objective:

This study aims to resist the increasing risk of APT attacks in the construction of new
power systems, this paper proposes an attack detection model based on Deep Packet Inspection
(DPI) and Transformer.

Methods:

Firstly, we extracted 606 traffic characteristics from the original traffic data through the
extended CIC Flowmeter and used them all to train the Transformer network. Then, we used the
DPI-Transformer model and traffic labels to perform feature analysis on the traffic data and finally
obtained the APT-Score. If the APT-Score is greater than the threshold, the alarm module is triggered.

Results:

By analyzing the headers and payloads of the network traffic in the APT-2020 dataset, the
experimental results show that the detection accuracy of APT attacks by the DPI-Transformer detection
model is significantly higher than that of the current mainstream APT attack detection algorithms.

Conclusion:

Combined with the characteristics of the new power system and APT attacks, this paper
proposes an attack detection model DPI-Transformer, which proves that the model has greatly
improved the detection accuracy.
Bioremediation of Hydrocarbons
Authors: Ijoma Grace N. , Nurmahomed Weiz , Matambo Tonderayi S. , Rashama Charles , Gorimbo Joshua
Published: May 2023

Hydrocarbons are a common contaminant in both terrestrial and aquatic
ecological systems. This is most likely due to the widespread use of hydrocarbons as
everyday energy sources and precursors in the majority of chemical manufacturing
applications. Because of their physical and chemical properties, most hydrocarbons in
the environment are resistant to degradation. Although several derivatives are classified
as xenobiotics, their persistence in the environment has induced microorganisms to
devise ingenious strategies for incorporating their degradation into existing
biochemical pathways. Understanding these mechanisms is critical for microbial
utilization in bioremediation technologies. This chapter focuses on recalcitrant and
persistent hydrocarbons, describing the reasons for their resistance to biodegradation as
well as the effects on ecological systems. Furthermore, aerobic and anaerobic
degradation pathways, as well as ancillary strategies developed by various
microorganisms in the degradation of hydrocarbon pollutants, are discussed.
PATHOPHYSIOLOGY IN CLUSTER HEADACHE: AN UPDATE
Authors: Octina Wa Ode Intan Nur , Kurniawan Shahdevi Nandar
Published: May 2023

Cluster headache (CH) is a rare and very painful primary headache syndrome, with an estimated population prevalence of 0.12%. This condition can be episodic (ECH), lasting from 7 days to a year. A consensus statement from the European Headache Federation defines refractory CCH as a CCH with at least three severe attacks per week, even though at least three consecutive trials of adequate preventive care have been tested and managed with both acute and preventive treatment. Inhaled oxygen and subcutaneous sumatriptan are the two most effective acute treatment options for people with CH. Several preventive medications are also available, and the most effective is verapamil. However, most of these agents are not supported by strong clinical evidence. In some patients, this option may be ineffective, particularly in those with chronic CH. Surgical procedures for chronic refractory forms of disorder should then be considered.
Um estudo empírico sobre a validade da hipótese de flutuação na aquisição do artigo em português por aprendentes chineses
Authors: Zhang Jing
Published: May 2023

A aquisição do artigo é um processo no qual os aprendentes de L2 estabelecem gradualmente um valor semântico apropriado para o parâmetro do artigo. Segundo a Hipótese de Flutuação (Ionin, 2003), os aprendentes de uma L2 flutuam entre a marcação dos traços de definitude e de especificidade na escolha do artigo, o que é considerado uma propriedade temporária do sistema da sua interlíngua. Com uma longa exposição ao input da L2, os aprendentes vão estabelecendo o valor paramétrico adequado do artigo. O presente estudo visou testar, junto dos aprendentes chineses cuja L1 não possui este sistema linguístico, a validade da Hipótese de Flutuação. Os dados corroboraram a flutuação na escolha de artigos portugueses por este grupo de aprendentes de nível A2/B1 de proficiência em português, tendo apontado para o input de L2 e a Gramática Universal como fontes de conhecimento linguístico a que os aprendentes chineses recorrem para a aquisição do artigo em português. Esta pesquisa poderá contribuir como suporte teórico para o ensino do artigo em português a aprendentes chineses.
1991 to 2019: The rise of machine interpreting research
Authors: Dias Esqueda Marileide , Freitas Flávio de Sousa
Published: May 2023

Conceived as a scientometric study, this paper searches for understanding the research status of machine interpreting on the IEEE (Institute of Electrical and Electronics Engineers) database from 1991 to 2019. Documents were analyzed considering a series of measures such as most prominent academic institutions and countries that investigate machine interpreting, citation, co-authorship, keywords co-occurrence, reference coupling, and textual-based analysis retrieved from the documents’ titles and abstracts. Through VOSviewer software and its tools for data collecting and visualization, machine interpreting research in the analyzed corpus focuses on three main concerns: machine translation, speech synthesis, and Japanese language.
Рост пленок SiC, AlN и GaN на кремниевых изделиях произвольной геометрии для микроэлектромеханических применений
Authors: Кондратенко Т.Т. , Гращенко А.С. , Осипов А.В. , Редьков А.В. , Убыйвовк Е.В. , Шарофидинов Ш.Ш. , Кукушкин С.А.
Published: May 2023

A technique is proposed for the formation of epitaxial films of silicon carbide, gallium and aluminum nitrides on the surface of non-planar silicon parts. Using the technique, a GaN/AlN/SiC/Si heterostructure was grown on the surface of a silicon ring. The samples were studied by scanning electron microscopy, as well as raman and energy dispersive spectroscopy. It is shown that the preliminary deposition of a SiC layer on silicon by the atomic substitution method, in which (111) facets are inevitably being formed regardless of the local crystallographic orientation of the substrate surface, makes it possible to efficiently grow subsequent layers of III-nitrides of both wurtzite and sphalerite types on silicon parts.
Магнитное поле внутри и вне тороидального плазменного шнура с током, удерживаемого в равновесии внешним аксиальным полем
Authors: Соколов И.В. , Боровиков Д.Б.
Published: May 2023

We provide a description of magnetic field inside and outside of a circular plasma ring carrying an electric current. The equilibrium is maintained by an external axial magnetic field. The provided solution is close to that by Titov and Demoilin (1999), but our solution is more general and accurate
Низкочастотные шумы и сопротивление фотодиодов с незащищенной поверхностью на основе InAsSbP/InAs в атмосфере паров этанола
Authors: Левинштейн М.Е. , Матвеев Б.А. , Dyakonova N.
Published: May 2023

Low frequency noise and electrical characteristics of p-InAsSbP/n-InAs single heterostructures grown onto n+-InAs substrates have been measured in the presence of atmosphere containing ethanol vapor. Correlation between ethanol vapor density and electrical spectral noise density as well as the heterostructure resistance has been estimated, and possible reasons for such correlation have been discussed.
Преимущественное распыление сплава NiTi атомарными и кластерными ионами
Authors: Иешкин А.Е. , Черныш В.С. , Киреев Д.С. , Сенатулин Б.Р. , Скрылева Е.А.
Published: May 2023

X-ray photoelectron spectroscopy was used to study the evolution of NiTi alloy surface composition under bombardment with atomic and cluster argon ions. A strong enrichment of the surface with nickel was found for both atomic and cluster ions, which is inconsistent with contemporary understanding of preferential sputtering. Possible reasons for this result are discussed.
Параметры холодной плазменной струи, генерируемой в потоке гелия при контактном и бесконтактном инициировании
Authors: Гугин П.П. , Закревский Д.Э. , Милахина Е.В. , Швейгерт И.В.
Published: May 2023

Comparative studies of the generation of a cold plasma jet atmospheric pressure in helium excited by a sinusoidal voltage with different methods of its initiation have been carried out. The frequency and temperature ranges of the plasma jet, acceptable for exposure to biological objects, were determined.
Динамика извлечения электронов из сеточного плазменного катода на основе дугового разряда низкого давления
Authors: Москвин П.В. , Воробьёв М.С. , Гришков А.А. , Торба М.С. , Шин В.И. , Коваль Н.Н. , Дорошкевич С.Ю. , Картавцов Р.А.
Published: May 2023

The paper proposes and experimentally demonstrates a method for estimating the coefficient of electron extraction from a plasma emitter based on a low-pressure arc discharge with layered/grid stabilization of the emission plasma boundary. The method is based on the exclusion of the emission current from the total current in the accelerating gap by "sharp" switching off the arc discharge current. The condition for the applicability of the method is an insignificant change in the concentration of the anode plasma during the cutoff of the discharge current pulse. The preliminary data obtained testify in favor of a change in the electron extraction coefficient by up to 20% during a discharge current pulse with a duration of 150 μs.
3D Printing of MXenes-Based Electrodes for Energy Storage Applications
Authors: G Aadharshini , Gupta Nisha , Saha Prosenjit , Bhattacharya Pallab
Published: May 2023

Energy storage devices (ESD) including batteries, and supercapacitors are becoming progressively imperative in the transition to a renewable energy future, as they enable the integration of intermittent renewable sources into the grid and provide backup power during outages. There are already reviews available on various energy storage materials and systems. However, the challenges in the choice of suitable materials and fabrication technology are yet to establish for the commercialization of affordable and efficient ESDs in every aspect of practical needs. Therefore, we realize that the review on the newly developed two-dimensional (2D) MXenes-based energy storage electrodes and devices fabricated through suitably advanced 3D printing technology is the need of the hour, and will be able to attract broad audiences of the related field. MXenes are a class of 2D materials having lamella structures that have shown great promise for energy storage applications due to their versatile redox behavior, high surface area, high electrical conductivity, and ability to accommodate intercalated ions. However, the processing of 2D MXenes suffers from serious agglomeration due to weak Van der Waals attraction and reduces its actual energy storage performances. In a few recent studies, it is observed that advanced 3D printing has enabled the fabrication of MXenes with complex and customized geometries, opening up new possibilities for developing high-performance energy storage devices. Therefore, this review is important for a comprehensive discussion on this topic. So, in this review, we discuss the recent breakthroughs in 3D printed MXene-based batteries and supercapacitors, the advantages of using 3D printing for the fabrication of tailor-designed MXenes-based ESDs, existing challenges, and the opportunities available for further exploration towards the successful commercialization of ESDs. Overall, this review is an insightful articulation for the future seeking to stay at the forefront of this exciting and rapidly-expanding field.
Supporting Public Health Research Capacity, Quality, and Productivity in a Diverse Region
Authors: AlHamawi Rana , Saad Randa K , Abdul Rahim Hanan F , Mir Islam Saeed Khwaja , Husseini Abdullatif , Khader Yousef , Al Nsour Mohannad
Published: May 2023

Public health research plays a critical role in strengthening health systems and improving their performance and impact. However, scholarly production in public health coming from the Eastern Mediterranean Region (EMR) remains well below the world average and lacks a tangible growth trend over time. During the seventh Eastern Mediterranean Public Health Network Regional Conference, a roundtable session brought together a panel of public health experts representing Global Health Development/Eastern Mediterranean Public Health Network affiliates, universities or academia, and research institutions from the region, where they shared insights on the current situation of public health research; challenges and barriers to research facing the different countries in the EMR and the region in general; and how research agendas, productivity, and quality can be supported through strengthening research capacity in the region. Although the region is diverse in terms of health system capacity and socioeconomic development, several common challenges were identified, including a lack of strategic prioritization to guide health research, insufficient funding, ineffective transfer of knowledge to policy and practice, limited availability of research facilities, and limited national and international research collaboration. Occupied countries and countries in a state of conflict, such as Palestine, face additional barriers, such as personal and social security, lack of control of borders and natural resources, travel and movement restrictions, and confidentiality challenges because of the continuing war conditions and occupation. However, there have been success stories in the EMR regarding research publications and their positive and effective impact on policy and decision-makers. To improve research resilience and public health care in the region, a collaborative approach involving institutions, policymakers, and relevant stakeholders is critical.