bluuebunny/crossref_metadata_2025 huggingface dataset:
Romanian Tourism Branding Model
Authors: Ștefan Maria-Cristina , Ionescu Luiza , Andreiana Violeta-Andreea
Published: July 2024

Destination marketing is a complex process that involves creating a unique identity for a location, which is essential for attracting visitors and promoting the destination. This identity is created through a comprehensive branding approach beyond just creating logos. Instead, it involves a 360-degree holistic approach that considers the destination's heritage, values, and other key elements that make it stand out from other locations. Once the destination's brand has been established, it forms the foundation of all marketing activities to promote the location and attract new visitors. All content and messages should be aligned with the destination's brand identity to ensure consistency and maximum impact. The brand of a destination is crucial to its success, and this is especially true for Romanian tourism. This is why we are highly motivated to develop a comprehensive branding model that will help establish a strong brand identity for Romanian tourism. This model will be based on careful research and analysis of the unique characteristics of Romanian tourism, including its heritage, values, and other key elements that make it a popular destination for visitors.
The Use of Artificial Intelligence in Project Management
Authors: Duică Mircea Constantin , Vasciuc Săndulescu Cristina Gabriela , Panagoreț Dragoș
Published: July 2024

The emergence of new technologies, especially artificial intelligence (AI), disrupts the functioning of organizations on many levels (processes, organization, strategy, communication, finance, etc.). These changes particularly affect the managerial function at the heart of organizations. AI is changing many aspects of managers' work, such as planning, organizing and monitoring work, as well as human resource management, including recruiting, training and developing employees.

Technological advances, including AI, have profoundly influenced project management, leading to significant changes in the way projects are planned, organized, and monitored. Artificial intelligence is playing an increasingly important role in project management, providing managers with useful tools and data for decision-making and resource optimization. This can bring efficiency and precision to project management, helping to achieve set goals more effectively.

The use of these new work tools that make it possible to improve the efficiency of tasks calls into question the existing management practices and requires an upgrade of the skills of managers so that they can fulfill their mission. In addition to the technical skills essential to handling new technological tools, managers must demonstrate emotional intelligence and openness to fulfill their role. Indeed, the introduction of new AI technologies within organizations can have direct and indirect effects on the work of managers. On the one hand, they have to adapt to the technologies that target their own tasks. On the other hand, they need to adapt their management methods to support their employees in the digital transformation that affects other aspects of the organization's operation. In this article, we first outline the main AI technologies used in the managerial field, followed by the advantages and potential these technologies offer to organizations. We then focus on the changes in the role and responsibilities of managers and the new skills they need to develop to succeed in their new work environment. The last part of the article addresses the challenges and problems that the application of these technologies raises in relation to the managerial profession.
Pengembangan Majalah Sekolah Digital dengan Basic Design untuk Meningkatkan Literasi Digital di SMKN Jenawi Karanganyar
Authors: Shanty Sabrina Davina , Lukitasari Evelyne Henny , Wibowo Yudi
Published: July 2024

Peningkatan literasi digital menjadi salah satu fokus pemerintah dalam beberapa tahun terakhir untuk menghasilkan sumber daya manusia yang unggul dan kompetitif, terutama pada kalangan pelajar. Salah satu langkah yang diambil adalah mengembangkan majalah sekolah ke dalam bentuk digital dan menerapkan pengetahuan dasar desain dalam pembuatan majalah sekolah untuk menarik minat baca siswa. Tujuan dari penelitian ini adalah membuat sebuah majalah sekolah digital dengan menerapkan dasar desain untuk menarik minat baca siswa sehingga dapat menumbuhkan dampak yang baik pada pengetahuan dan sikap. Hasilnya, 94% siswa menyatakan bahwa desain majalah yang menarik dapat meningkatkan minat literasi mereka. Metode yang digunakan adalah kualitatif,  dengan pengumpulan data melalui observasi lapangan, survei, dokumentasi, dan analisis literatur menggunakan pendekatan deskriptif.
Analisis Landscape dan Kartun pada Karya Lugas Syllabus
Authors: Wahyu Muhammad
Published: July 2024

Esensi seni adalah kreativitas. Kreativitas adalah perkara menghubung-kaitkan segala sesuatu yang tadinya tak terhubung. Kreativitas lahir dari berbagai gagasan yang dirangkai sedemikian rupa. Dari situlah muncul berbagai keunikan, kekhasan, dan keberagaman. Dari hal itu dapat dikatakan bahwa berfikir tentang seni itu dalam, dengan dan melalui seni kehidupan keseharian dapat dibuat menjadi lebih indah, menyenangkan, dan merangsang orang untuk mencipta dan berinovasi. Dalam artikel ini, secara lebih khusus sampel yang menjadi objek penelitian adalah 3 karya lukisan dari seorang perupa asal Sumatera Selatan, yaitu Lugas Syllabus. Seni landscape pada lukisan Lugas Syllabus adalah simbolisme tentang perbatasan. Uniknya dalam landsacape Lugas Syllabus gemar menggunakan imaji figur fantasi popular dari berbagai latar belakang. Sepintas lukisan Syllabus tampak  riang dan ringan. Tetapi di balik itu, terkandung makna yang dalam. Ketertarikan peneliti terhadap karya Lugas Syllabus adalah pada  visualisasi dan konseptualnya yang menggabungkan banyak simbol dalam perjalanan karirnya di setiap karya Syllabus. Oleh karenanya, penelitian ini menggunakan pendekatan semiotika. Penelitian ini diharapkan dapat menjadi referensi untuk menambah wawasan dalam proses kreatif seorang perupa bagi masyarakat umum.
Pengembangan Dimensi Spiritual Manusia melalui Seni Rupa
Authors: Putri Dhian Riskiana , Prihwanto Puji
Published: July 2024

Masyarakat modern terlalu mengutamakan kebutuhan materi sehingga larut dalam gaya hidup materialis dan hedonis. Akibatnya, manusia modern mengalami kekeringan dalam sisi spiritualitasnya. Manusia modern menjadi lebih rentan terhadap stress saat menghadapi tekanan persoalan kehidupan yang makin berat. Orang yang tidak mampu mengatasi stress dengan baik maka hidupnya akan selalu dalam kecemasan, bahkan bisa menjadi depresi. Depresi yang tidak mendapat penanganan secara baik menyebabkan gangguan jiwa dan memicu perilaku bunuh diri. Tingginya angka perilaku bunuh diri beberapa tahun terakhir menunjukkan rendahnya nilai spiritualitas manusia modern. Kajian tentang spiritual telah dilakukan oleh para ilmuan dalam bidang psikologi. Dalam psikologi, spiritual dan agama memiliki dimensi yang berbeda. Seseorang dapat memiliki nilai spiritual tinggi tanpa harus menjadi religius. Salah satu kegiatan manusia yang memiliki potensi spiritual adalah kesenian. Penelitian ini dilakukan untuk mengetahui pengaruh kegiatan kesenian seni rupa dalam pengembangan spiritual manusia. Metode yang digunakan dalam penelitian adalah kualitatif dengan teknik validasi data menggunakan teknik triangulasi. Hasil penelitian ini menunjukkan bahwa seni rupa mengandung potensi spiritual, sehingga dapat digunakan sebagai sarana manusia untuk meningkatkan dimensi spiritualnya.
Perbandingan Efisiensi dan Kualitas Rendering V-Ray dan Enscape pada Model Roster Beton di Sketchup
Authors: Nareswarananindya - , Laksono Sigit Hadi , Hidayat Mochamad Junaidi
Published: July 2024

Penelitian ini membahas tentang evaluasi perbandingan jumlah tahapan dan durasi render menggunakan mesin render VRay dan Enscape pada obyek roster dengan material beton. Metode yang digunakan yaitu dengan metode simulasi komputer dengan pengujian render yang menjabarkan proses dan tahapan render secara detail, sehingga dapat diketahui jumlah tahapan dan durasi render dengan obyek yang sama dengan hasil rendering yang menyerupai material acuan beton yang telah ditentukan. Tujuan dari penelitian ini yaitu untuk mengetahui keunggulan dan kekurangan dari masing-masing mesin render. Hasil dari penelitian ini adalah perbandingan kepraktisan tahapan render dalam skala jumlah dan perbandingan durasi render dalam skala detik antara plugin VRay dan Enscape.
Perancangan meja TV dengan desain parametrik menggunakan bahan limbah kayu lapis
Authors: Fariz Nuthqy , Hutasoit Nicolas MP , Sany Nukhbah
Published: July 2024

The Indonesian wood industry is an industry that is favorable by the foreign consumers, with a steady increase in sales—even in the midst of a pandemic. One of the impacts arising from the increased production process is the increased wood waste produced. This research was conducted as an effort to utilize the abundant wood waste to become a TV table furniture that has high aesthetic value by using a parametric design. The method used is the design thinking, with the research results in the form of a working drawing design and a prototype of TV table furniture with a parametric design. The aesthetic assessment showed that 77% of the total respondents stated that the design and prototype of the TV table had an aesthetic shape and value.
Hydrogen Production from Aluminum Waste Using the Aluminum-Water Method with Potassium as Activator
Authors: Amelia Icha , Rohendi Dedi , Rachmat Addy , Syarif Nirwan , Yulianti Dwi Hawa , Sya'baniah Nyimas Febrika , Adhiyanti Nurmalina , Adelia Ory , Normah Normah
Published: July 2024

The research on hydrogen production from aluminum waste using the aluminum-water method with potassium as an activator has been successfully conducted. This study aims to evaluate the performance of potassium as an activator in hydrogen production with water volume and potassium percentage variables. The method involves reacting aluminum waste-sized 60 mesh with potassium as an activator. The research results show that the optimum conditions are achieved with 1 gram of aluminum reaction by adding 1.5 mL of water and 7% w/w potassium, producing 553 mL of hydrogen gas at a 69 mL/min production rate. In conclusion, potassium as an activator effectively enhances hydrogen production from aluminum waste.
Sweet flag (Acorus calamus L.) rhizomes chromatography column isolates potential as rich antioxidant compounds
Authors: Amalia Suci ,   Chemistry Study Program, Faculty of Science and Technology, Maulana Malik Ibrahim Islamic State University, Malang, Indonesia, 65144, Hasibuan Lili Sunarti , Arianti Ninit Arinda , Fasya A Ghanaim , Dewi Diana Chandra , Kadarani Deva Krisna
Published: July 2024

Plant biodiversity in Indonesia is the prospective solution to overcome the top issues in the pharmacy sector, such as the unavailability of local materials in the purposing of independently manufacturing pharmaceutical products. One of the plants that can be used for raw materials in the biopharmaceuticals is a sweet flag (Acorus calamus L.), which is rich in bioactive compounds such as flavonoids, alkaloids, phenolic compounds, tannins, steroids, saponins, glycosides, and terpenoids. Flavonoids are the majority bioactive compounds in sweet flag rhizomes, which leads this study to identify the flavonoids as antioxidant agents for biopharmaceutical product development later. This study determined the antioxidant activity of sweet flag rhizomes as its crude extract, ethyl acetate fraction, and column isolate. Based on phytochemical tests, column isolates were identified only to contain flavonoid compounds. Liquid chromatography Mass Spectrometry (LC-MS) in ethyl acetate fraction identified isorhamnetin, quercetin, kaempferol, genistein, and glycitein. Additionally, this study aims to show that column isolate has the highest purity level with the least inhibitory concentration of 50% (IC50) and the strongest antioxidant activity
Soap Production from Waste Cooking Oil: A Review
Authors: Ahadito Bijak Riyandi ,   Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Indralaya 30662, South Sumatera, Indonesia, Afriani Siti Rakhmi
Published: July 2024

In the process of cooking, chemical reactions that happen to the vegetable oil render it unfit for consumption after multiple reusage, thus turning the oil into waste. Due to the abundance of such waste, it is important to have an easy way to turn waste cooking oil into another useful commodity. Production of soap is one of such method that could be widely applied by the public due to the easiness of its procedures and no involvement of hazardous chemical, in contrast to the production of biodiesel or biofuel which sometimes demands the use of unsafe materials or conditions. The objective of this publication is to provide information about the differences between unused and used cooking oil, to lay out the methods of soapmaking, to review the academic reports of soapmaking from waste cooking oil, and to summarize the challenges that are still unsolved in this topic.
Strategi Humas Inspiring Agency dalam Membangun Citra Positif Perusahaan di Kalangan Generasi Z
Authors: Muharizal Rizki Aditiya , Aulia Sisca
Published: July 2024

Image is a very important asset for an organization or company that should be continuously built, maintained and nurtured. Currently, companies operating in the insurance sector are competing to be at the forefront by following developments in information technology. Inspiring Agency is an insurance business unit headed by a Senior Agency Director. The business run by Inspiring Agency is PT Prudential's insurance business. This research aims to determine Inspiring Agency's public relations strategy in building a positive company image among generation Z. In this research the author uses a qualitative approach. The results of this research show that Inspiring Agency continues to strive to create a positive image, socialize its vision, and communicate with the public, especially generation Z. To achieve its goals, Inspiring Agency implements a structured planning strategy. This strategy is an implementation of Inspiring Agency's actions. In its strategy, Inspiring Agency applies publications, events, news, community involvement, image delivery, lobbying and negotiation, and social responsibility.
Citra merupakan aset yang sangat penting bagi organisasi atau perusahaan yang semestinya harus terus menerus dibangun, dipelihara, dan dipertahankan. Saat ini perusahaan yang bergerak pada bidang asuransi bersaing menjadi yang tedepan dengan mengikuti perkembangan teknologi informasi. Inspiring Agency adalah salah satu unit bisnis asuransi yang dikepalai oleh Senior Agency Director. Bisnis yang dijalani oleh Inspiring Agency adalah bisnis asuransi PT Prudential. Penelitian ini bertujuan untuk mengetahui strategi humas Inspiring Agency dalam membangun citra positif perusahaan di kalangan generasi Z. Pada penelitian ini penulis menggunakan pendekatan kualitatif. Hasil penelitian ini menunjukkan bahwa Inspiring Agency terus berusaha untuk menciptakan citra positif, mensosialisasikan visinya, dan berkomunikasi dengan masyarakat terutama generasi Z. Untuk mencapai tujuan, Inspiring agency menerapkan strategi perencanaan yang terstruktur. Strategi tersebut merupakan implementasi dari tindakan Inspiring Agency. Dalam strateginya, Inspiring Agency menerapkan publications, event, news, community involvement, inform of image, lobbying and negotiations, dan social responsibility.
Cytotoxicity effect and antioxidant potential of 5-Hydroxymethyl Furfural (5-HMF) analogues-An advance approach
Authors: Al-Baadani W. A. , Al-Samman A. M. M. A. , Anantacharya R. , Satyanarayan N. D. , Siddique N. A. , Maqati A. Al. , Kahkashan
Published: July 2024

Rivea hypocrateriformis (Desr.) Choisy is a profound medicinal belongs to the family Convolvulaceae. Natural products are considered as an alternative source for a positive approach to the drug design and drug discovery. R. hypocrateriformis is becoming the most important natural source to produce diverse phytometabolites with varying biochemical activities. Therefore, in the proposed study, we utilizing R. hypocrateriformis for isolating the 5-hydroxymethyl-2-furfural (5-HMF) and characterized it by different scientifically approved spectroscopic techniques namely 1HNMR, 13C NMR, FTIR and mass spectroscopy respectively. As a part of this study, the synthesis of chemical analogues has been achieved by coupling 5-HMF with quinoline derivatives and it was also studied for their antioxidant and anticancer potentials. The results demonstrated that amongst the test compounds, 3d and 3b have shown significant free radical scavenging assay followed by 3e and 3a with a maximum inhibitory effect, 76.69 %, 75.90 %, 67.60 % and 56.07 % respectively at 50 μg/mL. The anticancer activity studied through SRB assay showed that, compound 3a was effective at low concentration (10 μg/mL) against the Colo-205 cell line. This study demonstrated the applicability of R. hypocrateriformis against the cytotoxicity and antioxidant potential of 5-HMF. It can further be utilized by the researcher and pharmaceutical industry to design a potential drug candidate to treat cellular toxicity.
A long goodbye: Ed and Mary's journey with Lewy Body Dementia
Authors: Baldwin Adele , Anderson Stephen , Inskip Michael , Johns Kellie , Lindsay David , Mathiesen Bronwyn , Bodak Marie
Published: July 2024

Often the lessons to be learned from recipients of care are overshadowed by more formal learning strategies. Ed’s story is one of compassion, strength, laughter, loyalty and loss. It chronicles the journey of caring for a loved one diagnosed with Dementia with Lewy Bodies. Unfortunately, diagnosis of any form of dementia is more frequent in our communities than many of us are aware. Very few people, however, journal their story as their lives, and that of those around them, change. Thus, the richness of learning from recipients of formal care and support is a unique opportunity for all health professionals working in dementia care. Further, the raw, honest insights in Ed’s story are a valuable learning tool for any health professional from any discipline, particularly those who are still learning their craft. Sometimes the impact our words and actions have on patients and families is not apparent, and Ed’s reflections allow us a glimpse into how the actions and words affect them, both positively and negatively.
نقد الليبرالية في الفكر السياسي الفرنسي المعاصر ادغار موران والاَن دي بينواست أنموذجاً
Authors: العبيدي م.د وليد مساهر
Published: July 2024

لقد أسست الليبرالية منذ نشأتها على الحرية والفردية والعقلانية في توسيع مفهومها كمنظمة فكرية تحاول النهوض بالفرد وحقوقه والمساعدة على ترسيخ مكانته على حساب المجتمع وعدم الحد من حريته، وعلى الدولة أن تضمن ما لا يستطيع وحده أن يضمنه لنفسه وهو الأمن والحماية، لكن رغم أن هذه الأسس أعطت الحرية والحقوق للفرد الا انها حرمت الأغلبية منها ولم تضمن المساواة بينهم، بالإضافة إلى تحويل هذه المبادئ من سياسة وطنية إلى سياسة دعائية دولية وغطاء للتدخل في شؤون الدول وفرض ثقافتها وقيمها عليها، مما أدى إلى انعدام الحوار بين الشعوب بسبب اختلاف الثقافات، وأجبرت الإنسان على العيش في انانية واغتراب وغيرها من الأزمات التي تتطلب إصلاحات جذرية تزعمها إدغار موران وآلان دي بينواست الذين قدموا لها رؤية نقدية.
"الديمقراطية في سياق النظرية الشعبوية: دراسة للمفهوم وتأثيرها في مسارات دمقرطة الأَنظمة"
Authors: جواد م.نواف عبدالقادر
Published: July 2024

يناقش البحث الشعبوية المعاصرة ونظريتها حول الديمقراطية، التي قدمت في ثناياها حلولًا لتجاوز المغالطات التي أصابت المشروع الديمقراطي ولإعادة بناءه ومراجعة أُسسه وخصوصًا في جانبه التمثيلي، إِذ عدته من الإِجراءات الملتبسة التي يتوجب تجاوزها أو تعزيزها كونها سببت عجزًا عن تمثيل الشعب والتعبير عن إِرادته، لعدم وفاء المنتخبين بوعودهم وتجاهلهم لناخبيهم بعد بلوغهم السلطة، تقترح النظرية الشعبوية بأن الحل يكمن في اعتماد ديمقراطية أَطلقت عليها الديمقراطية المباشرة الاستقطابية، التي يباشر فيها الأَفراد التشريع والحكم من خلال الاستفتاء كوسيلة وحيدة تمكّن الشعب من الحكم الآني، بلا انتظار نفاد مدة ولاية المنتخبين لمعاقبتهم، كما تسعى تلك الديمقراطية في بعدها الاجتماعي إِلى تقويض شخصنة السلطة وتغيير مفهوم الشعب بعد إِرساء ضربًا من الحكم يستبعد الهيئات الوسيطة بين الشعب والسلطة، وهذا ما يفسر الرؤية السلبية الشديدة للنظرية الشعبوية للبرلمانات والأحزاب والصحافة والمحاكم الدستورية.
Do Maladaptive Imaging Beliefs Predict Self-Reported Pain Interference and Physical Function in Patients With Musculoskeletal Disorders?
Authors: Plante Jacqueline , Kucksdorf Joseph , Ruzich Jon , Young Jodi L. , Rhon Daniel I.
Published: July 2024

OBJECTIVE: To determine if maladaptive imaging beliefs correlated with, and predicted pain interference and physical function outcomes in people with musculoskeletal pain disorders.

DESIGN: A prospective cohort study of patients with musculoskeletal disorders receiving outpatient physical therapy from April 2022 to August 2023.

METHODS: Four questions about imaging were asked to assess maladaptive beliefs, the need to rule out serious conditions, guide treatment, determine diagnosis, and validate symptoms. Correlations with beliefs and outcomes were assessed using Kendall’s tau rank and Spearman’s rho correlation coefficients. Generalized linear models determined if these beliefs predicted outcomes at baseline and 6 weeks.

RESULTS: The cohort included 152 participants (mean [standard deviation] age: 56.13 [15.13]; 32.2% male). Maladaptive imaging beliefs correlated positively with pain interference and negatively with physical function. The need to rule out serious conditions and validate symptoms correlated with pain interference (range: τb = 0.17, 0.20; P = .003, .0121) and physical function (range: ρ = −0.22, −0.22; P = .006, .008). All but 1 belief correlated with pain interference (range: τb = 0.19, 0.24; P<.001, .004) and physical function (range: ρ = −0.26, −0.21; P = .001, .009) at 6 weeks. Each additional belief slightly increased pain interference at 6 weeks ( β = 0.01; 95% CI: 0.001, 0.03; P = .04) and lowered physical function at both baseline ( β = −0.97; 95% CI: −1.66, −0.28; P = .01) and 6 weeks ( β = −0.76; 95% CI: −1.37, −0.15; P = .02).

CONCLUSION: Maladaptive imaging beliefs were significantly (albeit weakly) correlated with pain and physical function. Each additional maladaptive imaging belief increased pain interference at 6 weeks and lowered physical function at baseline and 6 weeks. Beliefs about the necessity of imaging to properly manage musculoskeletal disorders may influence outcomes. J Orthop Sports Phys Ther 2024;54(9):608-617. Epub 5 July 2024. doi:10.2519/jospt.2024.12625
Physicians’ Perceived Barriers and Willingness to Initiate Advance Care Planning with Young Adults Living with Cardiometabolic Diseases
Authors: Ekore Rabi Ilemona , Ekore John Oselenbalu , Mohammed Hany Ramadan
Published: July 2024

Objectives:

The current global practice is to plan for the end-of-life period of persons already terminally ill with chronic diseases. However, affected persons should not have to wait till the stage of terminal illness to begin making plans for future healthcare preferences. This pilot study explored perceived barriers to and willingness of physicians to initiate discussions on advance care planning (ACP) with young adults living with cardiometabolic diseases.

Materials and Methods:

The study was the pilot phase of descriptive cross-sectional research conducted among primary care physicians practising in Kuwait. Pilot data was collected with an electronic version of the modified DECIDE questionnaire (adapted from the “DECIsion-making about goals of care for hospitalized ElDErly patients” study) from February to April 2023. Data were analysed with Google Sheets.

Results:

Nine out of 22 participants exited the study early on grounds of non-familiarity with the concept of ACP. Thirteen responses were analysed and reported herein. The mean age of the participants was 44.2 (±7.9) years; eight were male and five were female; five were Hindu, 7 Muslim, and 2 Christian. Perceived barriers to initiating ACP discussions included lack of knowledge about ACP and its relationship to ACP and goals of care discussions (8), lack of knowledge about the legal status of ACP documents in Kuwait (11), religious disapproval (12), lack of knowledge about how to elicit values, beliefs, preferences related to end-of-life care (13) and fear that these conversations will diminish hope in patients with serious illness (12), among others. Twelve participants were willing to initiate discussions and exchange information with young adult patients. Twelve participants indicated that they were confident about initiating discussions and exchanging ACP information, had all not taken any extra training or certification in ACP, but, respectively, described their current level of skill in having ACP discussions and supporting patients in the finalisation of their advance care plans as limited (2), fair (3), average (4), very good (3) and expert (1).

Conclusion:

Despite the low level of awareness and other factors perceived as barriers, the primary care physicians who participated in the study were confident and willing to initiate ACP discussions with young adults living with cardiometabolic diseases. With the generally reported lack of previous training in ACP, there might be a need for coordinated efforts in training or up-skilling on knowledge and practice of ACP among primary care physicians.
Integrated bioinformatic analysis for the Identification of Potential Genetic markers in Hepatocellular Carcinoma
Authors: Rai Tirthal , Adiga Usha S.
Published: July 2024

Objective of the study was to identify differentially expressed genes (DEGs) and miRNAs as potential genetic markers to differentiate cancerous versus non-cancerous hepatic tissues as well as to compare the DEGs in those patients with and without IL-28B gene polymorphisms using bioinformatics tools. Microarray data (GSE41804) of liver tissue with/without cancer, deposited by Hodo et al8 was obtained from NCBI GEO database. Genotyping of patients with HCC associated with chronic hepatitis C was carried out to determine the association between the IL-28B genotype (rs8099917) and clinical outcome. The gene expressions were analysed using integrated bioinformatics. R software was used to process the data: Gene ontology and the KEGG database for the enrichment of pathways, STRING database for protein-protein interactions, TARBASE software to obtain miRNAs of DEGs and STITCH for drug-gene interactions. Polymorphisms of IL-28B gene were analysed by SIFT and Polyphen softwares. A total of 50,810 genes were extracted from which 250 differentially expressed genes (DEGs) were downloaded. Top 20 highly significant DEGs (p<0.00035) were analysed in detail. DEGs in cancerous tissues with major allele (TT of rs8099917) showed two upregulated genes (SPINK1, VAMP4) and five downregulated genes (MGMT, TREH, PXDC1, BGGAT1 and FREM2) as compared to non-cancerous tissues. In case of tissues with minor alleles (TG + GG), proportion of DEGs was equal. In cancerous tissues with major allele, ITGA1 and TNFAIP8L were upregulated, GPR84 gene was downregulated as compared to cancerous tissues with minor alleles. hsa-miR-335-5p, hsa-miR-940, has-miR-23a-3p etc. were the predominant miRNAs. String analysis showed 189 nodes,430 edges, average node degree 4.55, protein enrichment value p<1.0e. The study demonstrates the efficacy of bioinformatics analytic approaches in identifying probable pathogenic genes for HCC associated with hepatitis C. The interaction network identified miRNAs, hsa-miR-335-5p, hsa-miR-940 and genes TREH and TRIM16 as the key genetic markers for HCC.
Role of some Abiotic stresses in the production of Vincristine and Vinblastine from Catharanthus roseus callus
Authors: Alaakel Solaf , AL-Ammouri Youssef , Shehada AL-Ouda Ayman
Published: July 2024

The experiment was carried out at the National Commission for Biotechnology during 2019–2021 with the aim of studying the influence of some abiotic stresses on the fresh and dry weight and the content of vincristine and vinblastine in Catharanthus roseus callus. After sterilization, seeds were cultured in MS medium. Plants were transferred to propagation media. Callus was developed from the leaves using 5C01 medium. After 60 days, the callus was moved to the 5C01 medium with NaCl (0, 30, 60, 90, 120 mM) and PEG-6000 (0, -0.2, -0.4, -0.6 MPa) with a higher level every 30 days. The findings revealed that fresh and dry callus weight considerably decreased in the 120 mM NaCl treatment (3.03, 0.24 g respectively) and at the osmotic stress level of -0.6 Mpa (2.34, 0.19 g respectively). The vincristine and vinblastine content were significantly higher at the NaCl induction level of 90 mM NaCl (94.29, 103.6 μg.g-1 DW respectively), while they were considerably lower at the osmotic stress level of -0.6 Mpa (2.61, 3.12 μg.g-1 DW respectively). This research suggests a new medium (5C01) for callus induction which is distinguished by superior levels of vincristine and vinblastine in the callus compared to other studies.
Improvement of fractured oil well performance in Yuzhno-Priobskoye field, OOO Gazpromneft-Khantos
Authors: Шагалеев Р.К. , Гареев А.М. , Корсуков М.В. , Гуторов Ю.А.
Published: July 2024

В статье рассмотрено совершенствование технологии ГРП для повышения технологической и экономической эффективности данного метода за счет снижения выноса проппанта из трещины вместе с добываемой продукцией. Показано, что если снижение продуктивности скважин после ГРП из-за падения пластового давления может быть стабилизировано или восстановлено за счет системы ППД, то влияние на этот процесс выноса проппанта фактически не поддается воздействию. Предложен целевой фонд скважин для проведения термозакрепления для достижения оптимальных показателей работы скважин после ГРП.

This paper discusses improvement of hydraulic fracturing technology through reducing proppant flowback. It has been shown that reduced well deliverability after frac jobs due to reservoir pressure decline can be stabilized or restored through reservoir pressure maintenance systems. However, decreased well productivity due to proppant flowback can hardly be recovered. Use of resin systems or resin-coated proppant has been proposed in a number of wells to prevent proppant flowback for efficient fractured well operation
An improved method for thermochemical treatment of oil reservoirs
Authors: Резаи К.М.
Published: July 2024

Основным средством разработки месторождений с высоковязкими нефтями является тепло, закачиваемое в продуктивный пласт. Мы представляем усовершенствованный метод термогазохимического воздействия. Представляемая технология отличается бинарностью используемых смесей (БС), то есть селитра плюс нитрат натрия. Данная технология представляет более совершенный метод по сравнению с обычным ТГХВ. Кроме нового состава метод дополнен системой контроля управления за режимом закачки реагентов и реакцией БС на забое скважины.

The primary recovery method for high-viscosity oil is thermal treatment of formation. In this paper, we present an improved modification of thermal-gas-chemical treatment technique. A distinctive feature of the presented technology is application of binary mixtures, namely niter plus sodium nitrate. This is a more advanced technique compared to conventional thermal-gas-chemical applications. In addition to a novel chemical composition, the technique uses the control system which enables managing reactant injection conditions as well the reaction of binary mixtures at well bottom.
Problems of removal asphaltene paraffin sediments at Udmurtia and Tatarstan oilfields on modern stage
Authors: Марков Андрей Валентинович , Липаев Александ Анатольевич
Published: July 2024

В данной работе рассматриваются существующие методы борьбы с асфальтосмолопарафиновыми отложениями (АСПО). На основании приобретенного опыта на месторождениях Удмуртии и Татарстана, был сделан вывод о высокой эффективности применения теплового метода, который необходимо оптимизировать с точки зрения энергозатрат

In this article we consider the existing methods of dealing with asphaltene sediments. Based on the experience gained on the fields of Udmurtia and Tatarstan, it was concluded that the high efficiency of the thermal method, which should be optimized in terms of energy consumption
Friction bearings to improve centrifugal pump durability friction bearings to improve centrifugal pump durability
Authors: Яхин Ренат Рустемович , Зубаиров Сибагат Гарифович , Багманов Анас Абдрахманович
Published: July 2024

В статье описан способ увеличения ресурса нефтяного центробежного многоступенчатого насоса за счет изменения его конструкции путем замены подшипника качения в полевом подшипниковом узле на подшипник скольжения. В этом случае уменьшается расстояние между опорами насоса, что увеличивает устойчивость ротора насоса, повышается герметичность и безопасность эксплуатации насоса. Приведен обзор применяемых современных материалов для изготовления вкладышей подшипников скольжения и их анализ. Особое внимание уделено подшипнику скольжения с вкладышем из резины, так как в этом случае происходит дополнительное демпфирование колебании ротора насоса. На основании анализа зависимостей виброскорости от вынуждающих частот колебаний для резиновых смесей с разным содержанием в их компонентном составе техуглерода даны рекомендации по подбору компонентного состава резиновой смеси в зависимости от необходимой рабочей частоты вращения ротора насоса.

This paper describes a method to increase multistage centrifugal pump life due to alternating its design by replacing a rolling bearing in the outboard bearing assembly with a friction type bearing. In this case, distance between pump support assemblies reduces, which results in enhanced pump rotor stability and improved pump leak integrity and safety. A review of the existing advanced materials that are used for manufacturing of friction bearing liners is presented in this paper. Particular attention is given to a friction bearing with a rubber liner, in which case pump rotor vibrations are damped to a greater extent. Based on the analysis of vibration velocity versus oscillation frequency relationships for rubber compositions with varying carbon content, some guidelines are provided for selecting rubber composition in terms of the required pump speed.
ASPECTS OF HYDRAULIC FRACTURE PROPAGATION IN TATARSTAN FIELDS
Authors: Салимов В.Г. , Салимов О.В.
Published: July 2024

Проанализированы опубликованные материалы по микросейсмическому мониторингу гидравлического разрыва пласта в Татарстане. Проведено сравнение с результатами зарубежных и отечественных исследований в других регионах. Сделаны следующие выводы: 1. Поле горизонтальных напряжений на глубинах 1400 – 1700 м практически изотропно. 2. В этих условиях техногенные трещины будут развиваться по направлениям естественных трещин, образуя зону трещиноватости. 3. Расширение зоны трещиноватости продолжается и после прекращения закачки жидкости в скважину. 4. В дальнейшем необходимо проводить микросейсмический мониторинг с целью калибровки показателя сложного напластования и критического напряжения.

This paper reviews publications on microseismic monitoring of hydraulic fracturing operations performed in Tatarstan fields. Results of foreign and domestic research in other regions have been compared. The following conclusions have been made: 1. Horizontal stress field at a depth of 1400-1700 m is almost isotropic. 2. Under such conditions, the induced fractures tend to propagate along the direction of natural fractures, thus generating a fractured zone. 3. Expansion of the fractured zone continues after the injection stops. 4. It is necessary to perform microseismic monitoring for proving complex stratification and critical stress parameters.
Estimating geomechanical properties of Bazhenovskian-Abalakskian rocks for predicting fractured zones
Authors: Красников А.А. , Меликов Р.Ф. , Павлов В.А. , Субботин М.Д. , Емельянов Д.В. , Ахмадишин А.Т.
Published: July 2024

На основе данных специальных комплексов ГИС, результатов лабораторных исследований керна для скважин Ем-Еговского месторождения создана модель геомеханических свойств горных пород бажено-абалакского комплекса (БАК), рассчитано их напряженное состояние, определен индекс хрупкости. Построена псевдо 3D-модель распределения индекса хрупкости в интервале БАК Ем-Еговского месторождения

Special logging and laboratory-based core analysis data for the wells of Em-Egovskoye field were used to create a geomechanical model for the Bazhenovskian-Abalakskian productive play, to estimate the state of stress in the rocks mass, and determine rock brittleness index. A pseudo-3D model of brittleness index distribution within the Bazhenovskian-Abalakskian rocks of Em-Egovskoye field was constructed
FORMULATION OF ACID CORROSION INHIBITORS
Authors: Набиев М.С. , Мингазова Л.Р. , Мингазов Р.Р. , Башкирцева Н.Ю.
Published: July 2024

Кислотные обработки призабойной зоны пласта (ПЗП) основаны на способности кислоты, растворять нефтесодержащие карбонатные породы. Такой метод обработки карбонатного материала позволяет увеличить или восстановить проницаемости пород в призабойной зоны скважины. Путем удаления загрязняющих материалов, которые при бурении или эксплуатации скважин внедряются в пласт, и за счет расширения суженых участков поровых каналов достигается увеличение проницаемости.  От загрязненности призабойной зоны пласта и от пластового давления зависит степень увеличения дебита скважин. Эффективность применения такой обработки, как правило, продолжается несколько месяцев. Использование соляной кислоты при обработке призабойной зоны пласта приводит к значительной коррозии металлов и водородному и хлоридному растрескиванию под напряжением насосно-компрессорных труб. В настоящей работе рассмотрены способы получения ингибиторов кислотной коррозии и исследована ингибирующая защита полученных композиций. В качестве основы в композициях были использованы катионные поверхностно - активные вещества: аликилтриметиламмоный хлорид (АТМАХ) и алкилдиметилбензиламмоний хлорид (АДМБАХ). Гексаметилентетрамин (ГМТА) и йодистый калий использовались в качестве модифицирующих добавок для композиционных ингибиторов коррозии. Для композиционного состава с применением йодистого калия максимальный ингибирующей эффект составил 95,4%, а в случае применения гексаметилентетрамина при соотношении АДМБАХ:ГМТА 1:1 – 89,7%. В качестве ингибитора сравнения в работе был использован ингибитор кислотной коррозии ВНПП-2В, у которого максимальная ингибирующая эффективность при 93 оС составляет 94%.

Matrix acidizing technology is based on the acid ability to dissolve oil-bearing carbonate rocks. This method provides increase or restoration of rock permeability in the near-wellbore area. Permeability is increased through removal of skin damage caused by plugging of pores during drilling and production operations. Acid treatments result in enlargement of constricted pore channels, thus providing improved permeability. Degree of production enhancement depends on the wellbore damage and reservoir pressure. Operational benefit is usually observed for several months after treatment. Use of hydrochloric acid during acidizing results in significant metal corrosion and hydrogen-induced and chloride-induced delayed cracking of tubing strings. This paper discusses formulation of acid corrosion inhibitors and studies the inhibiting properties of these mixtures. Surfactants were used as the base of the inhibiting systems, including alkyltrimethylammonium chloride and alkyldimethylbenzylammonium chloride. Hexamethyleneamine and potassium iodide were used as modifying agents in corrosion inhibitors. Maximum inhibiting effect is 95.4% when using potassium iodide and 89.7% when using hexamethyleneamine. VNPP-2V was used as a model inhibitor having maximum inhibiting effect of 94% at 93oC.
TOMOGRAPHIC IMAGING OF CORE SAMPLES VALIDATES THE FEASIBILITY OF SURFACTANTS IN EOR TECHNOLOGIES
Authors: Шайхразиева Л.Р. , Орехов Е.В. , Аленькин Д.А.
Published: July 2024

Одним из необходимых условий понимания микропроцессов, влияющих на эффективность технологий нефтеизвлечения является информация о характеристиках пор. Исследование структуры пустотного пространства проводилось с применением томографических исследований образцов и дальнейшим созданием цифровой модели для определения характеристик горной породы. Объектом исследования является керн, отобранный из двух интервалов (1444,0 1449,0 и 1496,0 1502,0), ВишневоПолянского месторождения. На основании результатов исследований кернового материала определены значения возможного снижения капиллярного давления в результате применения ПАВ

Knowledge of pore characteristics is essential for understanding of microscale processes that affect the performance of oil recovery technologies. In the present research effort, the study of pore space structure has been conducted with application of tomographic imaging of core samples followed by creation of a numerical model to determine rock characteristics. Studies were conducted with core samples extracted from two intervals (1444.0 1449.0 and 1496.0 1502.0) of the VishnevoPolyanskoye oil field. Results of core studies provided expected capillary pressure drops due to surfactants.
THE PROPOSALS DEVELOPMENT FOR RECULTIVATION OF THE SLUDGE BARNS AT THE ENTERPRISE OF OJSC «SURGUTNEFTEGAZ»
Authors: Борисова Е.А. , Красноперова С.А.
Published: July 2024

В настоящее время широко используемая практика прошлых лет так называемой рекультивации нефтешламовых амбаров путем засыпки песком не решает проблему загрязнения почв, так как последнее приводит к длительной консервации углеводородов нефти и нефтепродуктов без доступа воздуха. На основании эколого-геохимических и фитоценологических исследований предложен комплекс мер по рекультивации нефтешламовых амбаров. В качестве мероприятий предлагается засыпка амбаров нефтешламов после откачки нефти и воды грунтами в качестве которых используются песок, торф и другие почвогрунты. Для деятельности углеводородокисляющих микроорганизмов необходимо внесение минеральных удобрений. На заключительной стадии мероприятий рекомендована фиторекультивация путем нанесения на поверхность нефтешламового амбара торфа, удобрений и посадки нефтетолерантных растений. В качестве последних рекомендованы кострец безостый, лисохвост луговой, овсяница красная, пырей ползучий, мятлик луговой и клевер луговой. Также предлагается способ восстановления загрязненных участков объектов нефтедобычи путем посадки черенков ив, что значительно понижает себестоимость посадочных работ и позволяет сравнительно быстрее получить желаемый эффект по сравнению с другими методами.

Today, the widely used traditional method of the so-called reclamation of oil sludge pits by covering them with sand does not solve the problem of soil contamination because this results in long-term conservation of oil and oil products without air access. Based on ecological-geochemical and plant-sociological studies, a number of measures have been proposed for oil sludge pit reclamation. These involve filling of sludge pits after oil and water have been pumped out with different materials, including sand, peat, and other soils. Application of chemical fertilizers is required for hydrocarbon oxidizing bacteria activity. The final stage of reclamation is recommended to include phytoremediation which means covering the oil sludge pit surface with peat, fertilization and setting of oil-tolerant plants. The recommended plants are a smooth brome, a red fescue, a false wheat, bulbous bluegrass, and a meadow clover. Another method of remediating oil-contaminated soils involves planting of willow cuttings, which significantly reduces cost price of planting and allows achieving the desired results more quickly than in other methods.
APPLICATION OF CRM MODELS FOR ANALYSIS OF WATERFLOOD PERFORMANCE
Authors: Поспелова Т.А. , Зеленин Д.В. , Ручкин А.А. , Бекман А.Д.
Published: July 2024

Для решения задач анализа системы заводнения при проектировании разработки зрелых нефтяных месторождений предлагается использовать новый подход к идентификации параметров эффективности системы ППД на основе модели CRM. В этом подходе взаимодействие скважин аппроксимируется исходя из промысловых данных по дебитам, приемистостям и забойным давлениям. В силу относительной простоты подхода настройка модели на промысловые данные не требует значительных временных затрат при сохранении достаточной точности прогнозов. Предложенная в статье методика анализа системы заводнения на основе моделей CRM включает в себя задачи оценки объемов непроизводительной закачки, оценки эффективности работы нагнетательного фонда, расчета текущей компенсации как по элементам заводнения, так и по отдельным добывающим скважинам.

A new CRM-modeling-based approach to identification of performance parameters for reservoir pressure maintenance systems is proposed to meet the challenges associated with the analysis of waterflood patterns for mature field development. This approach relies on approximation of well interference based on field data on production rates, well injectivities and bottomhole pressures. Due to relative simplicity of this approach, history matching is not time consuming and ensures adequate accuracy of the forecasts. The proposed CRM-modeling-based method for analysis of waterflood performance comprises evaluation of unproductive injection and performance of injection wells, estimation of current injection ratio by grid blocks and individual production wells.
Features of determining the mineral composition of rocks of the Lower Berezovskaya subformation on the example of Kharampursky gas condansate field
Authors: Александров Максим Александрович , Соловьёва Анна Владимировна , Аржиловская Наталья Николаевна , Шульга Роман Сергеевич
Published: July 2024

В работе рассмотрены проблемы, возникающие при установлении вещественного состава пород нижнеберезовской подсвиты. Нижнеберезовский резервуар сложен глинистыми опоками с высокой пористостью и низкой проницаемостью, глинистые минералы представлены смектитами, имеющими высокую способность к разбуханию в водной среде. Основным методом изучения вещественного состава является метод рентгеновской дифракции, но он осложнен наличием в составе пород нижнеберезовской подсвиты аморфного кремнезема, и глин с низкой кристалличностью, и плохой стехиометрией. Предложен методический подход при изучении пород коньяк-сантон-кампанского яруса рентгеноструктурным анализом.

In this paper, we consider the problems that arise when determining the mineral composition of the rocks of the Lower Bberezovskaya subformation. The Lower Berezovskaya reservoir is composed of clayey gaize with high porosity and low permeability; clay minerals are represented by smectites, which have a high swelling capacity in an aquatic environment. The main method for studying the material composition is the X-ray diffraction method, but it is complicated by the presence of amorphous silica and clays with low crystallinity and poor stoichiometry in the composition of the rocks of the Lower Berezovskaya subformation. A methodological approach is proposed for the study of the rocks of the Cognac-Santonian-Campanian Stage by X-ray diffraction analysis.