bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Affecting Performance of Financial Institutions: A Case Study of Afghanistan International Bank
Authors: Sarwar Mohammad Sulaiman , Shirzai Hamidullah , Ebrahimi Mohammad Shakir , Lalzai Faridullah
Published: December 2023

This study investigated and focused upon the risk management practices of banks in Afghanistan and their influencesd on banking performance. In recent years, the importance of risk management in banking institutions has grown significantly, particularly following the Global Financial Crisis. The study holds particular significance in the context of Afghanistan, a developing economy where the banking sector plays a vital role in national development. The continuity and success of banks in Afghanistan were intricately tied to effective risk management. This research aims to contribute to the ongoing debate surrounding risk management effectiveness in developing countries, specifically Afghanistan. It explores the relationship between risk management practices and banking performance while assessing the level of risk understanding and management in Afghan banks. The study's findings highlight the importance of risk understanding, risk assessment and analysis, managing credit risk, and managing liquidity risk in improving risk management practices in Afghan banks. These results provide valuable insights into enhancing the effectiveness of risk management in the banking sector.
Attention to Human Dignity and Its Role in Increasing Spirituality
Authors: Ahmady Sameer Ahmad , Ebrahimi Mohammad Yunus , Safi Shaidullah
Published: December 2023

The main purpose of this paper is to investigate about the dignity of human and its role in increasing the spirituality in light of Islam. The founding shows that spirituality has been considered as a desirable thing throughout humans’ life and lots of effort have been made to strengthen it. There are several factors that raise and cultivate spirituality, but among these factors, human dignity has essential role and basis. In this research, while explaining the concept of spirituality, the importance of human dignity in creating a spiritual personality is emphasized, and how the influence of human dignity in increasing spirituality will also be investigated, and it is proven that the source of spirituality is paying attention to inherent and deprivations, neglect and lack of attention to the position and dignity of the royal soul of man.
Livelihood Opportunities and Its Impact on Women in The Rural Areas of Afghanistan
Authors: Sidiqi Shir Alam
Published: December 2023

If women in rural areas have access to land, technology, financial services, education and markets like men, agricultural and non-agriculture (industry & services) production can be increased significantly, and the number of poor can be significantly reduced and impact the wellbeing of women in the rural areas. This paper aims to identify the possible livelihood opportunities for the poor people in the rural areas of Afghanistan, considering the current situation of the country, it requires to bring back at the center of focus to study the feasible livelihood opportunities and how it impacts the wellbeing of women in the rural areas of Afghanistan. Household headed women are in dire need in the rural areas of Afghanistan particularly after the collapse of the republic government after some of the restrictions were imposed on women. For analyzing the primary data model will be used for analyzing to determine the relationship between livelihoods opportunities and women lives in agricultural sector in rural areas of Afghanistan.
Alternative Cosmology: ΛCDM-Like Predictions Today
Authors:   University of Limoges 7 Avenue Georges Dumas, 87 000 LIMOGES, Independent Researcher, Limoges, France, Wojnow Stéphane
Published: December 2023

The theory of quantum mechanics and the theory of general relativity are both important with respect to the initial conditions of the universe and its evolution. In this paper we consider the question of how these theories might interrelate through a simple and didactic cosmological alternative model based on the Hubble time, Planck mass flow rate, and a variable coefficient αH. In doing so, we derive the parameters obtained by the Planck 2018 results using the Planck mass flow rate and Hubble time. By introducing a double universe theory (matter and antimatter universes arising from an initial instanton (i.e., half Planck mass) state, we sketch out a general framework for unifying, in the cosmology, general relativity with quantum field theory.‎‎
Muhammed B. Ahmed El-Avfî ve Kıraat İlmine Dair Eserleri
Authors: Ayan Hidayet
Published: December 2023

Bu çalışmada Muhammed b. Ahmed el-‘Avfî’nin hayatı ele alınmış ve onun kıraat ilmine dair eserleri incelenmiştir. XVI. yüzyılın ikinci yarısında Mısır’da dünyaya gelen ve daha sonra İstanbul’a hicret eden Muhammed b. Ahmed el-‘Avfî, kaleme aldığı eserlerle kırâat ilminin Osmanlı Devleti’nde gelişmesine ve yayılmasına katkı sağlamış bir âlimdir. Onun sahip olduğu kırâat müktesebatında hocası Ahmed el-Mesyerî’nin rolü oldukça büyüktür. ‘Avfî’nin ilmi birikimini; yazdığı eserler ve dâhil olduğu ilim meclisleri vesilesiyle sonraki nesillere aktardığı müşahede edilmiştir. O, bu meyanda kırâat ilminin alt disiplinlerine dair pek çok eser kaleme almıştır. Başta el-Cevâhiru’l-mükellele olmak üzere ‘Avfî’nin telifleri, kırâat sahasında istifade edilen kaynaklar arasına girmiştir. Ayrıca onun mezkûr eseri, Osmanlı coğrafyasına mahsus kırâat eğitim usûllerinden biri olan İstanbul tarîkine kaynaklık etmiştir. Çalışmada, kırâat edebiyatına ciddi katkılar vermesine rağmen kendisi ve telifleri hakkında yeterince malumat bulunmayan ‘Avfî’nin hayatı kaleme alınmış, bununla birlikte onun bu alandaki behresinin ortaya konması için eserlerine değinilmiştir. Araştırmanın neticesinde kırâat ilmine dair farklı konularda yüzlerce eser telif eden ‘Avfî’nin bu ilmin gelişimine ve sonraki nesillere aktarımına büyük katkı sağladığı tespit edilmiştir.
The Guggenheim equation for a system of hard spheres and its generalization
Authors: Nikolaev P. N.
Published: December 2023

In the present work, for the first time, the generalized Guggenheim equation for a system of hard spheres
is obtained based on the use of the Euler accelerated convergence method. This equation allows taking into
account an arbitrary number of known virial coefficients. For a metastable region, this equation is generalized
to the case of taking into account the asymptotic behavior of the free energy at high densities. The resulting
expression for the compressibility of the homogeneous phase of a system of hard spheres describes the data
of a numerical experiment within their accuracy.
On blow-up and on global existence of weak solutions to Cauchy problem for some nonlinear equation of the pseudoparabolic type
Authors: Katasheva I. K. , Korpusov M. O. , Panin A. A.
Published: December 2023

It is a brief exposition of results of the investigation of Cauchy problem for some nonlinear equation of pseudoparabolic type that is a generalisation of some model of semiconductor theory. In the paper, the potential theory for the linear part of the equation is elaborated, which demanded quite intricate technique, which can be used in other equations. The properties of the fundamental solution of this linear part are also of interest, because of the singularity of its 1st time derivative. This is not usual for this type of equations. Also, we obtain sufficiant conditions of solvability and of finite-time blow-up.
Suppressing of even harmonics in free electron lasers by modifying the energy spread of the beam
Authors: Zhukovsky K.
Published: December 2023

Using an analytical description of the evolution of the power of harmonics in free electron laser (FEL) undulators, we
study the effect of electron beam parameters on the main characteristics of FEL radiation: the gain length, spectrum,
and harmonic power. The possibility of suppressing even harmonics of the FEL as a light source in the study of materials
and surfaces by analyzing the second harmonic nonlinear response (SHG) is being studied. The main factors influencing
the radiation of even FEL harmonics are revealed; the influence of the beam cross section and the spread of electron
energies on their radiation is analyzed. An example of a LEUTL FEL with visible light emission, which is used in studies
of the optical properties of materials and the chemical state of molecules on surfaces and interfaces between media, is
considered. In this context, the possibility of suppressing the second FEL harmonic is analyzed.
On the choice of monitoring procedure of optical coating deposition
Authors: Tikhonravov A. V. , Lagutina A. A. , Lagutin Yu. S. , Lukyanenko D. V. , Sharapova S. A. , Sharov A. N. , Yagola A. G.
Published: December 2023

Theoretical results are formulated to assess the strength of the effect of self-compensation of errors in the thicknesses of layers of multilayer optical coatings. They are applicable to any method of optical monitoring of the deposition process. It is shown that considering a possible presence of a strong error self-compensation effect is of great importance for choosing a monitoring method. A comparative analysis of the results obtained to date to assess the strength of the error self-compensation effect for various types of coatings has been carried out. Moreover, a number of results were obtained for the first time directly in this work. The results obtained can be used to select the optimal method for monitoring the deposition process depending on the type of coating.
Physical laboratory for students practical laboratory works
of The Imperial Moscow University from the moment of foundation until 1917
Authors: Yakuta A. A.
Published: December 2023

The present survey, timed to a century and a half anniversary of practical laboratory works in Physics being
introduced in the curriculum of The Imperial University of Moscow for the students of the Faculty of Physics,
provides a broad coverage of its functioning in the period from 1873 to 1917. The author gives a brief overview
of the history of its founding, includes the data concerning the development of its equipment infrastructure,
stuffing and figures about the number of students who took physics labs in those years. The contents of
practical laboratory works are being analysed. The author vividly shows that professor A. P. Sokolov’s “Guide
to exercises in general physics labs of Physical Institute of The Imperial University of Moscow” relies heavily
on “Guide to Practical Classes in Physics” by F. Kohlrausch. The author familiarizes the readers with some
historical references, which enable to better enhance the readers’ understanding of the details of practical
training of physics students in The Imperial University of Moscow at the end of the 19th and the beginning
of the 20th century. The article also contains rare historical pictures, some of which are published for the first
time.
ANALGESIA MEDICAMENTOSA NO MOMENTO DO PARTO
Authors: Sales Maria Ralum Sousa , Macedo Pollyana de Cássia
Published: December 2023

Introdução: O uso de analgesia medicamentosa no momento do trabalho de parto normal tem se tornado cada vez mais frequente, sendo que esse procedimento tem favorecido o controle da dor, levando a um bem estar da puérpera. A dor, quando não controlada, pode provocar consequências fisiológicas negativas, tanto para a mãe quanto para o feto, e por este motivo é importante o seu tratamento. Objetivo: Realizar uma revisão de literatura a respeito do uso de analgesia medicamentosa no trabalho de parto, apontando as principais evidências encontradas. Metodologia: Revisão integrativa de literatura, sistematizando os achados, elencando pesquisas sobre a temática e categorizando publicações de maneira clara e objetiva. Para a busca, utilizou-se os bancos de dados: Google Acadêmico, Scientific Electronic Library Online (Scielo) e National Library of Medicina (PubMed). Resultados: Foram selecionadas 20 publicações que possuem como foco a analgesia medicamentosa no trabalho e parto. Nos artigos selecionados, o ano de 2021 foi o que mais apresentou publicações (n=8), seguido do ano de 2022 (n=4) e do ano de 2018 (n=3). A maioria dos artigos foram publicados em português (n=14), em periódicos de anestesiologia (n=8). O tipo de estudo realizado nas publicações selecionadas, o mais prevalente foi o descritivo/transversal (n=9). Conclusão: Dentre as várias técnicas disponíveis de analgesia para o parto, a via neuroaxial tem se mostrado mais eficaz, sendo a peridural a técnica mais comumente utilizada.
INSUFICIÊNCIA CARDÍACA, DISFUNÇÃO ERÉTIL, DISTÚRBIOS DO SONO E EXERCÍCIO FÍSICO - REVISÃO DE LITERATURA
Authors: Vieira Adriany , De Carvalho Tales , Fachi Jaquelini , Sties Sabrina Weiss
Published: December 2023

Introdução - A Insuficiência Cardíaca (IC) é caracterizada pela incapacidade do coração em suprir as necessidades fisiológicas do corpo. Afeta aproximadamente cerca de 26 milhões de pessoas no mundo. A IC tem sido associada à ocorrência de disfunção sexual masculina (DS) e distúrbios do sono. Neste contexto, o exercício físico é uma estratégia terapêutica com elevado nível de evidências científicas bem documentadas.  Objetivos: descrever os principais mecanismos fisiopatológicos e a repercussão terapêutica do exercício físico nas três morbidades (IC, DE e DRS).  Método: Revisão da literatura. As buscas por artigos científicos foram conduzidas de forma manual e intencional, por um único pesquisador, as buscas foram realizadas nas bases de dados eletrônicas (PubMed, LILACS, Cochrane-Library, Science Direct). Considerações Finais: Os resultados apresentados nesta revisão demonstram a relação positiva entre o exercício físico e o controle dessas três condições (IC, DE e DRS), sendo, portanto, fortemente recomendado o seu uso como no tratamento da IC e de algumas morbidades a ela associadas (comorbidades), como a DE e o DRS.
DIAGNÓSTICO E MANEJO NA ATRESIA DE VIAS BILIARES PÓS-COLECISTECTOMIA EM PACIENTE PEDIÁTRICO: RELATO DE CASO
Authors: Werner Laura Beatriz Firmino , Souto Bruna Luiza Ribeiro , Budtinger Filho Ricardo , Ambrosi Eduarda , De Arruda Ilana Falcão
Published: December 2023

Patologias das vias biliares (VVBB) são raras em crianças, sendo 1,3 casos pediátricos para cada 1000 casos em adultos2. A clínica geralmente é inespecífica e o índice de suspeição para o seu diagnóstico é baixo, sendo o quadro clínico, etiopatogenia e fatores de risco pouco presentes na literatura3. O tratamento para casos sintomáticos geralmente é a colecistectomia, sendo um procedimento raro no mundo pediátrico, com baixo índice de complicações relatadas2. O objetivo desde trabalho é relatar o manejo do caso de um escolar do sexo masculino com atresia de vias biliares após múltiplas reabordagens após colecistectomia.
A INOVAÇÃO NA PRODUÇÃO DE PEÇAS DE CAPIM DOURADO: UM ESTUDO COM ARTESÃOS NA REGIÃO DO JALAPÃO-TO
Authors: Pacheco Flavio Augustus da Mota , Porto Junior Gilson Rebouças
Published: December 2023

Este estudo tem por objetivo analisar as práticas de inovação presentes na produção e comercialização de peças de capim dourado entre artesãos pertencentes a uma associação de produtores de capim dourado na Região do Jalapão-TO. Trata-se de um estudo de caráter quantitativo. A unidade de análise desta pesquisa foi um grupo de 16 artesãos. O instrumento de coleta de dados foi aplicado digitalmente. Na pesquisa, percebeu-se haver baixo grau de inovação no processo produtivo de peças de capim dourado, entretanto, pode-se constatar alta correlação entre os produtores que procuram fazer relacionamento com seus clientes, com aqueles que fortalecem suas marcas em seus produtos para se diferenciarem dos competidores.
ENFERMAGEM: AS CONDUTAS FRENTE AOS CASOS DE VIOLÊNCIA CONTRA À MULHER
Authors: De Oliveira Vitória Fernanda Cavalcante , Lopes Graciana de Sousa
Published: December 2023

OBJETIVO: Compreender as dificuldades enfrentadas pela equipe de enfermagem na conduta às mulheres vítimas de violência. METODOLOGIA: Trata-se de um estudo de pesquisa bibliográfica que utiliza como técnica a Revisão Integrativa da Literatura. A busca foi realizada nas bibliotecas virtuais de pesquisa: BVS e SCIELO, combinando três DeCS, cruzados com o operador booleano “AND”: “Assistência” AND “Enfermagem” AND “Violência contra a mulher”. Foram encontrados 416 artigos nas bases de dados. Após análise da pesquisa, foram selecionadas 16 publicações para compilar esta pesquisa. RESULTADOS: Observa-se que não existem perfis de vítimas de violência e nem perfis de agressores. A violência não traz consequências apenas físicas, mas também psicológicas e sociais, e a enfermagem é um dos empregos que mais demanda a atenção dessas mulheres, e por sermos profissionais que estão mais próximos dos pacientes e cuidam deles, tanto nos serviços hospitalares quanto nos serviços de atenção primária. CONCLUSÃO: A partir deste trabalho podemos perceber que esse tipo de ajuda não é fácil de ser prestada por ser um momento doloroso para o paciente e é importante que esse tipo de ajuda seja prestada por uma equipe multidisciplinar para que haja uma melhor abordagem no momento. este momento.
SCHEDULING ANALYSIS IN CONSTRUCTION WITH THE PERT METHOD USING MICROSOFT PROJECT
Authors: Prasetyo Baskoro Adhi , Haris Muhammadun  , Laksono Djoko Nugroho
Published: December 2023

Since 2017, the Drinking Water Supply System (SPAM) of the Capital District (IKK) Ibu has not been functioning due to damage to the pipe network due to road widening work, damage to generators and pumps, thus PDAM West Halmahera will build a new SPAM network system with a gravity system and will analyze scheduling using the Program Evaluation and Review Technique (PERT) method using Microsoft Project 2021 to carry out development planning which has results where the time required for construction is 320 days and can be completed with a percentage level of 95.35%, with a critical path found in the implementation work occupational health and safety, preparation, piping work, procurement and installation of house connections and commissioning test work with a time of 273 days.
A Vulnerability to Storage Security for Cloud Computing
Authors: Afroz Md. , Goswami Birendra
Published: December 2023

Utilizing technology and new technologies in the digital world requires a safe and reliable environment as well as a consideration for all the challenges they present, and dealing with them. There is no exception to the rule of cloud computing being one of the new technologies in the IT world. Various studies reveal that one of the major challenges of this technology is the security and safety required for consumers to transfer their data into the cloud. In this paper by reviewing and highlighting security challenges in a cloud computing environment, we aim to highlight the security challenges that cloud computing poses. The article also offers some suggestions on how to enhance the security of data storage in cloud computing systems that using these suggestions can somewhat override the problems.
Pertinence of the teaching use of virtual classroom by Basic Biomedical Science Department
Authors: Pomares Bory Eduardo de Jesús , Vázquez Naranjo Odalys , Barrios Herrero Liliam , Arencibia Flores Lourdes Guadalupe , Bernardo Fuentes Manuela Gilda
Published: December 2023

Introduction: The use of digital technology is recognized as a strategic educational policy in higher education. Objective: To analyze the relevance of the virtual classroom as a teaching tool by the Basic Biomedical Science Department, Salvador Allende Health Sciences Faculty, Medical University of Havana. Methods: A descriptive, qualitative, case study-based research study was conducted. Theoretical methods, including analysis-synthesis, induction-deduction, historical-logical analysis, and ascent from the abstract to the concrete, were used. Empirical methods comprised documentary review and focus groups.Results: Established criteria enable the consideration of the instructional use of the virtual classroom as a departmental teaching innovation. Supported by digital technology, this represents a transition from traditional face-to-face teaching to a hybrid model. Conclusions: The use of the virtual classroom for teaching purposes by the Basic Biomedical Science Department, Salvador Allende Health Sciences Faculty, Medical University of Havana, stands as a pertinent teaching innovation, contributing to the digital transformation of medical education.
Removal of methyl green dye using activated carbon prepared from corn cobs
Authors: Akande James  , Shehu Isah  , Olayemi Ife  , Oguntolu Aderonke  , Otugade Zainab
Published: December 2023

Dyes released into hydrological systems in textile manufacturing, printing and other dyeing processes are hazardous and toxic to human and aquatic lives. Activated carbons have been remarkably used to treat dye contaminated waste water due to their large surface area and porosity, however regeneration and high cost have limited their applications. This study investigated the use of activated corn cobs (ACC) on the adsorption of methyl green dye from aqueous solution. The raw cobs were collected, crushed into particle size of about 600 μm and modified in-situ with KOH to prepare ACC which was characterized using some analytical techniques such as Fourier Transform Infra-Red (FTIR), Energy Dispersive X-ray (EDX) spectroscopy and Scanning Electron Microscopy (SEM). The absorbance of the dye solution was monitored at 620 nm with UV-Visible spectrophotometer. FTIR analysis showed the vibration frequency for C‒H, O‒H, C=O and C‒O stretches at 2950, 3400, 1710, and 1150 cm-1 respectively. SEM results revealed the ACC has a porous surface with heterogeneous pores which became compact after dye adsorption. EDX confirmed the presence of C, O, H and K in the adsorbent. The suitability of the pseudo-first, pseudo second and Elovich kinetic models for the sorption of methyl green onto ACC was examined. The equilibrium data were subjected to Langmuir, Freundlich, Tempkin and Dubinin-Radushkevich isotherm models. The pseudo-second order kinetic model provided the best correlation and was found to be more statistically significant. Langmuir model was found to fit well based on the high values of the coefficient of regression R2 and low % standard error values. The monolayer adsorption capacity Qmax was found to be 85.83 mgg-1. Thermodynamic adsorption processes showed the spontaneous, endothermic and randomness of the systems with free energy change less than zero, enthalpy change (∆H) of 62.47 kJmol-1and entropy change (∆S) of 125.37 Jmol-1K-1.
Optimization of extraction conditions by the dosage of polyphenols and determination of antioxidant activity: Case of Melothria maderaspatana organs, a plant used in traditional African medicine for the treatment of diabetes
Authors: Mame Coumba DIOP  , Bédié MBOW  , Aïssatou Alioune GAYE  , Birane DIOP  , Abba Diarra KONE  , Ibrahima DIALLO  , Abdoukhadre DIOUF  , Papa Biram SY  , Mouhamadou FOFANA  , Fatou Dieng FAYE
Published: December 2023

Melothria maderaspatana is a medicinal plant of Asian origin belonging to the Cucurbitaceae family. It has a wide range of phytochemicals such as alkaloids, flavonoids, tannins, saponins, steroids, terpenoids, phenolic compounds. The leaves, roots and fruits are considered to have stomachic activities. It is a plant very rich in phenolic compounds, generally responsible for the biological activity of plants. In this study, we optimized the extraction parameters, including temperature, duration and solvent mass/volume ratio, by determining the total polyphenol contents and the antiradical activity at DPPH●. The Folin-Ciocalteu reagent was used to evaluate the content of phenolic compounds, with gallic acid as a reference. The determination of flavonoids with AlCl3 was carried out with quercetin as a reference. The DPPH● radical made it possible to measure the antioxidant power of the extract, with reference to Trolox. This study showed that the optimal conditions for extraction of bioactive molecules, responsible for antioxidant activity, are obtained for a temperature of 80 °C, for a period of 30 min in a ratio of 1 g for 50 mL of extraction solvent which is distilled water. Under these conditions, the contents of total polyphenols and flavonoids are evaluated for the other organs of the plant. The values obtained ​​show that the three parts of the plant contain approximately the same polyphenol contents and exhibit the same DPPH● antioxidant activity. As for the flavonoid content, the leaves are revealed to be the richest part, compared to the stems and fruits. These physicochemical indicators in secondary metabolites and biological activity justify the primary choice reserved for this plant by traditional practitioners for the treatment of numerous pathologies.
Analysis of Tilapia Exports on Regional Original Revenue (ROR) of Dairi Regency, North Sumatra
Authors: Fadlan Ahmad , Pratama Andika
Published: December 2023

This research was conducted in Dairi Regency, North Sumatra. The purpose of this study was to determine the Export factors on local revenue of the Dairi Regency of North Sumatra. this uses quantitative and qualitative data and the model used is Path Analysis which is operated through the SPSS Version 25.0 for Windows program. In this study, the data collection method used was using a questionnaire with a Likert scale. The number of samples used was 20 tilapia fish entrepreneurs, the data collected by distributing questionnaires. Based on the results of path analysis testing directly Capital, Exchange Rates, Inflation, Exports, Production, Prices directly have a significant and positive effect on Regional Original Income (ROR), the purpose of this study is to analyse the effect of ROR on Capital, exchange rates, inflation, export production of tilapia prices in the Dairi district of North Sumatra. in this study shows that there are only two 2 variables that affect the regional original income of the dairi district, namely exports and selling prices that have a significant effect on the regional original income of the dairi district of North Sumatra. While capital, exchange rates, inflation, production have an insignificant effect on the local revenue of the Dairi district of North Sumatra.
The Influence Of Climate And Organizational Culture On Teacher Performance In Public Junior High Schools In Batu City
Authors: Novitasari Eka Dian , Sobri Ahmad Yusuf , Juharyanto Juharyanto
Published: December 2023

The purpose of this study was to determine the organizational climate and organizational culture on teacher performance. This research uses a Quantitative approach. The research subjects were teachers at the State Junior High School in Batu City. Data collection in this study used a questionnaire with a Likert scale of 1-5. The population in this study were all teachers at the State Junior High School in Batu City. While the sample in this study amounted to 302 respondents using saturated samples. There are four tests in this study, namely descriptive analysis test, data validity and reliability test, prerequisite analysis test, and the last data hypothesis testing. Based on the results of the study, there is an organizational climate Path coefficient value of 0.119, meaning that the organizational climate has a direct influence on teacher performance. Then the organizational culture Path coefficient value of 0.436 means that the organizational climate directly contributes to the influence on teacher performance. Thus, it can be concluded that organizational climate and culture affect teacher performance. The better the climate and organizational culture in the Batu City State Junior High School, the more teacher performance will also increase.
Activity of propolis compounds as potential MMP1 and MMP2 inhibitors by in silico studies in wound healing application
Authors: Arda Adzani Gaisani , Syaifie Putri Hawa , Ramadhan Donny , Jauhar Muhammad Miftah , Nugroho Dwi Wahyu , Kaswati Nofa Mardia Ningsih , Noviyanto Alfian , Safihtri Mega , Rochman Nurul Taufiqu , Andrianto Dimas , Mardliyati Etik
Published: December 2023

Context: Matrix metalloproteinases (MMPs) play a critical role in wound healing, with higher levels seen in chronic wounds, delaying healing. Since ancient times, propolis has been widely used for traditional wound healing. However, there is still limited research on MMP1 and MMP12. Aims: To evaluate new candidates of propolis compounds for targeting MMP1 and MMP12 using in silico studies supported by experimental screening using LC-MS/MS quadrupole-time of flight (QTOF). Methods: Compounds in propolis were screened using LC-MS/MS QTOF. The 3D structure of all compounds in propolis and protein targets was prepared in Autodock and Biovia Discovery Studio. The molecular docking of all compounds in propolis was carried out using Autodock on PyRx 0.9. Drug-likeness and ADMET analysis of selected compounds in propolis with the lowest affinity were observed. Lastly, molecular dynamic simulations of the best compounds in propolis were conducted using the GROMACS 2020 package. Results: Eleven flavonoid and phenolic compounds were identified in propolis using LC-MS/MS QTOF analysis. Molecular docking simulations showed that licoflavone A and pinostrobin exhibited the lowest binding affinity to MMP1 and MMP12, respectively. Molecular dynamic simulations revealed that licoflavone A formed a more stabilized complex with MMP1, while pinostrobin formed a more stabilized complex with MMP12 than the native ligand. Conclusions: This study revealed new candidates for MMP1 and MMP12 inhibitors from propolis compounds that can enhance wound healing. It is hoped that the evidence gathered in this study provides crucial new information in exploring new wound-healing medications.
KAJIAN KARAKTERISTIK DAN DEFORMASI CAMPURAN AC-WC DENGAN PENGGUNAAN SUBTITUSI LIMBAH MARMER SEBAGAI FRAKSI AGREGAT KASAR
Authors: Bea Liliyan , Basri Lambang , Alifuddin Andi
Published: December 2023

Repetitive and excessive load pressure by vehicles is one of the damages that occurs on road pavement deformation due to the pavement layer losing its strength, causing the road layer to subside and cracks to occur. Marble waste is the remaining waste acquired from the processing of the marbles. Environmental pollution is caused by the marble processing process. The marble waste produced is increasing gradually over time, therefore, it is needed to utilize that marble waste. The marble waste is expected to improve the quality and performance of the mixture in resisting deformation in the AC-WC mixture and has good mixture characteristics. This research aims to examine the cause of using marble waste on the characteristics and deformation of the mixture. The test in this research applies the marshall test and wheel tracking tool. The result showed that the characteristics of the mixture and KLMO, total deformation, deformation rate, and dynamic stability using KAO 6% and the Optimum Marble Waste Content (KLMO) obtained was 25%. The highest stability and Marshall Quatient were 1024.89 kg and 345.65 kg/mm at 25% marble waste variation. The lowest flow value in the mixture with 25% marble waste variation was 2.97 mm. The 25% variation has good mixture characteristics and durability. The smallest total deformation was 0.903 mm at 25% marble waste variation, dynamic stability 2864 passes/mm, and deformation rate 0.0147 mm/minute.
Pyrazoles as anticancer agents: Recent advances
Authors: Nikita Sharma  , Mamta Ahuja
Published: December 2023

The present review article offers a detailed account of the design strategies employed for the synthesis of nitrogen-containing anticancer agents. The results of different studies described the N-heterocyclic ring system as a core structure in many synthetic compounds exhibiting a broad range of anticancer activities.
Analysis of water quality in relation to the development of vaname shrimp cultivation (Litopenaeus vannamei) in Mandalle District, Pangkep Regency, Indonesia
Authors: Patang
Published: December 2023

The research aims to determine the possibility of developing vaname shrimp cultivation in Mandalle District, Pangkep Regency, based on an analysis of water quality aspects, which consists of physical and chemical aspects. The method used is a survey method by selecting five research locations that may have prospects for the development of vanamei shrimp cultivation. Sampling was carried out at five stations, namely location 1, namely at a location at the northern tip of Pangkep Regency, which borders the coast of Barru Regency. Location 2 is the location around the port of the Pangkep State Agricultural Polytechnic Campus; location 3 is in a location close to mangove vegetation; location 4 is at the mouth of the Mandalle Village River; and location 5 is in the part adjacent to the rice fields and traditional market of Mandalle Village. The water quality data collected includes data on salinity, oxygen, temperature, and pH of the water. The data was then analyzed using quantitative descriptive analysis. The results of the research show that based on the results of water quality analysis such as salinity, oxygen, temperature, and pH, the water is still in accordance with the growth and life needs of vaname shrimp, with salinity values in the salinity range of 15.83–33 ppt and dissolved oxygen of 3.02–4.67 ppm, temperature of 28.92–29.38oC and a water pH in the range of 6.0–6.73. Thus, the research location makes it possible to cultivate vanamei shrimp based on water quality aspects, which include physical and chemical aspects.
Impact of Green Marketing on Consumer Purchase Intention: The Moderating Role of Environmental Knowledge
Authors: Iqbal Asif Iqbal , Iqbal Muhammad Sikander , Athar Abdullah , Khan Salman Ahmed
Published: December 2023

In recent years, environmental sustainability has become a top priority in international politics and a vital driver of innovation. Green product companies are growing rapidly as consumers show more interest in environmentally friendly products. This study analyzes the impact of green marketing on customer purchase intention and how environmental knowledge moderates this relationship. Understanding how customers' environmental understanding influences their response to green marketing can help marketers and companies develop effective sustainability-focused marketing strategies The influence of environmental information and green marketing on consumer purchase intention is not clear. This study examines how environmental information and green marketing affect customers' purchase intentions. The study used a quantitative research design and collected data from 251 users of green products. The results show that Social Influence, Environmental Concern, Subjective Norms, and Perceived Green Control have a positive and significant effect on green purchase intention (GPI). Additionally, the results indicate that environmental knowledge moderates the relationship between GPI and Green Purchase behavior (GPB). This study provides valuable insights for green marketers and businesses by exploring the link between environmental understanding, green marketing, and customer purchase intention. It examines the complex relationship between green marketing, environmental understanding, and customer behavior to help marketers gain a better understanding of sustainability-focused marketing.
Disengagement of Youth with Student Politics in Pakistan: A Study of the Experiences of Politically Engaged Students
Authors: Yasir Ammar , Baloch Maheen , Ul Hassan Ali Ab
Published: December 2023

This paper seeks to understand the reasons behind students’ disinterest and disengagement in student activism in Pakistan through the experiences of politically active students. The methodology employed includes qualitative methods and in-depth interviews of student activists based on purposive sampling and snowball sampling. The findings reveal the complex relationship between the ban on student politics, violence and disinterest of the students, by calling into question the oversimplified notion of violence. The findings also highlight the issues of relatedness and alienation within student organizations and emphasize the approach of building inclusive and meaningful relationships. The study adds to the body of knowledge by offering insightful analysis and suggestions for governments, academic institutions and student organizations to re-engage students in meaningful political engagement. In the end, the study seeks to create a more diverse and active student political climate in Pakistan by bridging the gap between student activism and the disengaged majority.
ANALISIS IMPLEMENTASI STRATEGI PENYELESAIAN DALAM MEMINIMALISIR PEMBIAYAAN MURABAHAH BERMASALAH (STUDI KASUS BMT AMANAH MADINA)
Authors: Syahputra Andi , Sueb Mochammad
Published: December 2023

Analisis Strategi Penyelesaian Dalam Meminimalisir Pembiayaan Murabahah Bermasalah di BMT Amanah Madina. Pengamatan dan data yang terstruktur dapat menciptakan solusi dalam bentuk strategi yang ampuh dalam mengatasi segala permasalah di BMT Amanah Madina. BMT Amanah Madina menerapkan beberapa alternatif yang menurut saya sebagai penulis sangat bermanfaat dalam menyelesaiakan beberapa masalah yang muncul di BMT tersebut. Strategi penyelesaian tergantung dari permasalahan yang ada, dan pengamatan pihak Lembaga keuangan dan customer dalam penentuan alternatif penyelesaian dari permasalahan tersebut. Penulis menggunakan metode kualitatif dan pendekatan deskriptif dalam menyelesaikan penlitianya. Dengan menggunakan dua sumber data, yaitu data primer yang diperoleh dengan melakukan wawancara langsung kepada karyawan BMT Amanah Madina, selanjutnya adalah data sekunder yang diperoleh dari referensi mengenai pembiayaan bermasalah, pembiayaan murabahah, jurnal tentang teori strategi penyelesaian masalah, data mengenai pembiayaan murabahah dari internet dan penelitian terdahulu. Untuk tujuan analisis data, peneliti memakai metode induktif dalam menentukan cara berfikir dari informasi dan data perihal mekanisme pembiayaan dan Analisa kelayakan customer tentang validasi calon nasabah dalam pengajuan pembiayaan di BMT Amanah Madina.Hasil dari jurnal ini adalah adanya cara dan strategi yang solutif dalam menangani permasalahan pembiayaan murabahah dan bisa digunakan secara menyeluruh oleh Lembaga keuangan yang memiliki permasalahan terkait pembiayaan bermasalah.
PENGARUH KEPERCAYAAN NASABAH TERHADAP TABUNGAN HAJI DI BANK SYARIAH INDONESIA
Authors: Mufid Fatiyah
Published: December 2023

Bank Syariah Indonesia merupakan perbankan syariah terbesar di Indonesia karena hasil penggabungan ketiga bank milik negara. Salah satu produk tabungannya yaitu Tabungan Haji. Yang mana dalam Tabungan haji ini bisa dilakukan untuk perencanaan haji atau umrah dengan menggunakan akad mudharabah. Segmentasi dari Tabungan haji ini bisa untuk semua nasabah dengan kategori produk tabungan yang berbeda. Penelitian ini menggunakan metode kualitatif yang dimana pengambilan data bersumber dari jurnal, buku dan website.  Adanya penelitian ini  untuk menganalisis kepercayaan nasabah atau masyarakat terhadap Tabungan Haji di BSI. Sehingga kepercayaan nasabah terhadap produk di BSI sangat penting. Penelitian menunjukkan bahwa kepercayaan nasabah untuk menabung di Bank Syariah Indonesia sudah tinggi yang dilihat dari data survey tentang perencaan haji di website BSI.
MENINGKATKAN KEMAMPUAN GREEN ECONOMY DALAM MENDORONG PENGEMBANGAN DESA WISATA UNTUK MEWUJUDKAN PEMBANGUNAN YANG BERKELANJUTAN
Authors: Mairiza Khania Taris , Noviarita Heni
Published: December 2023

Pembangunan yang berkelanjutan kini menjadi tujuan utama dalam upaya mencapai kesejahteraan masyarakat, menjaga keberlanjutan lingkungan, dan mempromosikan pertumbuhan ekonomi yang inklusif. Green economy, yang menekankan pada pertumbuhan ekonomi yang tidak merugikan lingkungan dan memperkuat keberlanjutan sosial, menjadi landasan yang strategis dalam pengembangan desa wisata. Jurnal ini merupakan sebuah review dari beberapa seleksi jurnal-jurnal yang menjadi studi kasus dalam review ini. Pencarian literatur dilakukan dengan menggunakan database online Google Scholars. Temuan hasil penelitian ini adalah peneliti menyimpulkan, Meskipun banyak desa wisata telah mengadopsi konsep Green Economy sebagai landasan utama untuk pengembangan mereka, kenyataannya menghadirkan serangkaian tantangan yang perlu diatasi. Keterbatasan sumber daya, baik dalam hal keuangan maupun infrastruktur, menjadi kendala nyata yang menghambat kemampuan desa wisata untuk sepenuhnya merealisasikan potensi Green Economy mereka. resistensi masyarakat terhadap perubahan juga menjadi tantangan serius. Peningkatan pemahaman tentang konsep Green Economy juga perlu menjadi fokus utama dalam upaya mengatasi hambatan ini. Program edukasi, pelatihan, dan kampanye informasi dapat membantu menyadarkan masyarakat akan manfaat ekonomi, sosial, dan lingkungan dari penerapan Green Economy. Menyebabkan pemahaman yang lebih baik dapat mengurangi penolakan dan mendorong orang untuk berperan aktif dalam ekonomi keberlanjutan. desa wisata dapat mencapai transformasi yang lebih efektif dan berkelanjutan. Diperlukan kerja sama yang erat antara pemerintah, masyarakat, dan sektor swasta untuk menciptakan lingkungan yang mendukung perubahan positif.
PULMONARY TB COMPLICATED BY TRACHEOBRONCHIAL TB
Authors:   Central TB Research Institute, Moscow, Russia, Malikova O.G. , Komissarova O.G. ,   Central TB Research Institute, Moscow, Russia,   N.I. Pirogov Russian National Research Medical University, Moscow, Russia, Chumovatov N.V. ,   Central TB Research Institute, Moscow, Russia, Ergeshov A.E. ,   Central TB Research Institute, Moscow, Russia,   A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Published: December 2023

In the recent years we have observed a positive tendency towards better epidemiological rates of TB in the Russian Federation. Incidence and mortality rates fell to a record low. However, a share of patients with advanced or complicated pulmonary TB increased. Our review highlights epidemiological data, pathogenesis, clinical manifestations, diagnostics, and management of pulmonary TB complicated by tracheobronchial TB nowadays.
TUBERCULOSIS OR CANCER: CAUSES OF DIFFERENTIAL DIAGNOSTIC ERRORS
Authors:   Smolensk State Medical University, Smolensk, Russia, Myakisheva T.V. , Idobaeva O.P. ,   Smolensk State Medical University, Smolensk, Russia
Published: December 2023

We carried out an analysis of differential diagnostic errors among patients with cancer diagnosed in TB institutions in  Smolensk region in 2017–2021. Delayed diagnostics of tumors in the lungs or pleura was revealed. The causes of overdiagnosis of TB in patients with malignant tumors were as follows: the similarity of clinical and radiological signs of the diseases, the similarity of laboratory test results, false positive results of M. tuberculosis detection in sputum, lack of the recombinant tuberculosis allergen (RTA) test, misinterpretation of radiological data. In indeterminate cases it is vital to verify the diagnosis as soon as possible by performing biopsy from the pathological site.
ETIOLOGICAL VERIFICATION OF PULMONARY MYCOBACTERIOSIS BASED ON EXAMINATION OF RESECTION SAMPLES FROM PATIENTS WITH DIAGNOSIS А16.0 – ACTUAL PRACTICE
Authors:   Central TB Research Institute, Moscow, Russia, Karpina N.L. , Chashchina M.V. ,   Central TB Research Institute, Moscow, Russia, Egorova A.D. ,   Central TB Research Institute, Moscow, Russia, Smirnova T.G. ,   Central TB Research Institute, Moscow, Russia, Bagirov M.A. ,   Central TB Research Institute, Moscow, Russia,   Russian Medical Academy of Postgraduate Education, Moscow, Russia, Ergeshov A.E. ,   Central TB Research Institute, Moscow, Russia,   A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Published: December 2023

Objective: to evaluate effectiveness of etiological verification of pulmonary mycobacteriosis (PM) in patients with diagnosed “pulmonary TB without bacteriological or histological confirmation” (А16.0) as per ICD-10 and species diversity of nontuberculous mycobacteria (NTM) in resection samples from the studied cohort. Materials and methods.We analyzed test results from 28 patients with initially diagnosed “pulmonary TB without bacteriological or histological confirmation” (А16.0) as per ICD-10 and verified PM according to resection sample studies. The microbiological study (at least two sputum samples, one bronchobiopsy sample, and one resection sample) included luminescent microscopy (LUM), extraction of M. tuberculosis DNA or NTM DNA by polymerase chain reaction (PCR), culture growth on liquid media in the ВАСТЕС  MGIT  960 system, identification of mycobacteria by molecular genetic methods: real-time PCR for M. tuberculosis DNA detection (Syntol, Russia) and DNA-strip technology (GenoType Mycobacterium CM/AS Hain Lifescience). Results. The analysis of referral diagnoses established that in more than half of patients with diagnosed “pulmonary TB without bacteriological or histological confirmation” (А16.0) changes in the lungs had been referred to tuberculoma (64.3%) or infiltrative TB (21.4%); 28.6% of patients had received TB treatment as per chemotherapy regimen no. 3, and 17.8% of patients – broad-spectrum antibiotics. TB treatment duration varied from 4 to 28 months. Atypical lung resections were performed in most cases (75%). NTM DNA detection in resection samples was the most informative method of etiological verification of PMB (100% of cases). NTM culture growth was observed in 17.9% of cases. Only slowly-growing NTM were represented in the studied cohort as etiologically significant. Conclusion. The diagnosis verification is based on data obtained by microbiological and/or histological, cytological studies. Studies of resection samples from TB suspects significantly improve diagnostic effectiveness.
IMMUNOTHERAPY FOR TUBERCULOSIS
Authors:   Central TB Research Institute, Moscow, Russia, Yeremeev V.V , Shepelkova G.S. ,   Central TB Research Institute, Moscow, Russia
Published: December 2023

Immunotherapies that interfere with host defense cell mechanisms, enhance immune responses, reduce exacerbated inflammation, or balance host reactions on the site of pathology hold enormous promise for selective and symptomatic treatment of TB. Although we foresee a bright future for immunotherapy, this newly emerging treatment option should not be misinterpreted as an exclusive alternative, but rather it should be envisaged as a synergistic addition to canonical chemotherapy of TB.