bluuebunny/crossref_metadata_2025 huggingface dataset:
Comorbid conditions in patients with chronic tonsillitis
Authors:   Vernadsky Crimean Federal University, Georgievsky Medical Academy,  Simferopol, 295051, Russia, Zavalii M. A. , Kedrovskii D. M. ,   Vernadsky Crimean Federal University, Georgievsky Medical Academy,  Simferopol, 295051, Russia, Orel A. N. ,   Vernadsky Crimean Federal University, Georgievsky Medical Academy,  Simferopol, 295051, Russia, Krylova T. A. ,   Vernadsky Crimean Federal University, Georgievsky Medical Academy,  Simferopol, 295051, Russia, Asanova L. D. ,   Vernadsky Crimean Federal University, Georgievsky Medical Academy,  Simferopol, 295051, Russia
Published: February 2023

Various causes lead to chronic infection in the palatine tonsils. The development of more than 100 types of diseases is associated with the pathology of the tonsils. A chronic process can affect organs and systems in various ways – that is, conditions for the development of comorbid conditions appear. Comorbidity is the presence of two and/or more diseases in a patient, etiopathogenetically interconnected. As systemic manifestations in chronic tonsillitis, there can be diseases from the cardiovascular system, kidneys, musculoskeletal system, skin, central nervous system, oculomotor apparatus, liver, endocrine and reproductive systems. Patients with chronic tonsillitis often have pathology of the nasal cavity and paranasal sinuses. Due to the fact that chronic rhinitis contributes to a decrease in the functional activity of the palatine tonsils, the body’s immunity is significantly weakened. Often, pathogenetic treatment of chronic rhinitis contributes to a stable restoration of cellular and humoral immunity in patients with chronic tonsillitis. This further leads to the absence and decrease in the frequency of relapses and, thereby, to a decrease in the progression of a chronic disease with damage to internal organs and body systems. Timely involvement of an otorhinolaryngologist in the treatment of patients with chronic tonsillitis with comorbid diseases has a positive effect and makes it possible to achieve a transition to a stable remission or a decrease in the frequency of relapses, which undoubtedly plays a role in improving the quality of life.
Middle ear packing agents
Authors:   Saint Petersburg Research Institute of Ear, Nose, Throat and Speech,  Saint Petersburg, 190013, Russia, Khamgushkeeva N. N. , Chernushevich I. I. ,   Saint Petersburg Research Institute of Ear, Nose, Throat and Speech,  Saint Petersburg, 190013, Russia, Anikin I. A. ,   Saint Petersburg Research Institute of Ear, Nose, Throat and Speech,  Saint Petersburg, 190013, Russia, Kuzovkov V. E. ,   Saint Petersburg Research Institute of Ear, Nose, Throat and Speech,  Saint Petersburg, 190013, Russia, Dvoryanchikov V. V. ,   Saint Petersburg Research Institute of Ear, Nose, Throat and Speech,  Saint Petersburg, 190013, Russia
Published: February 2023

This review aims to describe the materials most commonly used for middle ear packing during tympanoplasty. These materials promote local hemostasis, limit wound surfaces, and fill the volume of the tympanic cavity. The usage of these materials is aimed at reducing the probability of developing cicatricial adhesive changes in the middle ear, stabilizing ossicular prostheses in the desired position, and maintaining the tympanic membrane graft. Main attention is paid to the description of the characteristics of materials and the results of their application in experimental and clinical studies. The pros and cons, possibilities and prospects of these materials usage in clinical practice are reflected.
In dogs diagnosed with osteoarthritis, how safe and effective is long-term treatment with bedinvetmab in providing analgesia?
Authors: Kronenberger Katrin
Published: February 2023

PICO question
In dogs diagnosed with osteoarthritis (OA), how safe is treatment with bedinvetmab, when compared to a placebo and how effective in long-term reduction of the severity of the clinical signs associated with OA-related pain?
 
Clinical bottom line
Category of research
Treatment.
Number and type of study designs reviewed
Two papers were critically reviewed. One was a randomised, blinded, multi-arm laboratory safety study; the other a multi-center field trial consisting of a block-randomised, double blind, placebo-controlled phase, followed by a non-comparative, open-label case series study.
Strength of evidence
Weak.
Outcomes reported
One study rated the reduction of the severity of clinical signs associated with OA pain using owner Canine Brief Pain Inventory (CBPI) ratings and non-validated veterinary clinical assessments (VCAs). Safety was addressed by evaluating adverse health effects (AHEs), concentration of antidrug antibodies (ADAs), and clinical pathology. Significant improvements in pain scores and VCAs were reported in this treatment study. The second safety-only study used clinical observation to evaluate AHEs. Both studies reported AHEs.
Conclusion
A single study suggests that treatment with bedinvetmab is effective. Two studies support the drug having few AHEs. Both studies have significant design limitations preventing the evaluation of bedinvetmab effectiveness. There is weak / inconclusive evidence for long-term efficacy and short-term safety of OA treatment with bedinvetmab. The decision to use bedinvetmab remains dependent on the judgement and experience of the clinician.
How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
La propuesta de Tommaso Greco. A propósito de La legge della fiducia. Alle radici del diritto
Authors: Asís Rafael de
Published: February 2023

La legge della fiducia. Alle radici del diritto, constituye una propuesta de comprensión del Derecho y, al mismo tiempo, una invitación a la reflexión sobre su significado y sentido. En estas breves reflexiones se abordan algunas de las cuestiones sobre las que el libro te invita a reflexionar y se plantean algunas dudas que suscita la propuesta de Tommaso Greco.
A General SBML Compatible Hybrid Modeling Framework: Combining Biochemical Mechanisms with Deep Neural Networks for Systems Biology Applications
Authors: Pinto José , Ramos João R. C. , Costa Rafael S. , Oliveira Rui
Published: February 2023

In this paper we propose a computational framework that merges mechanistic modeling with deep neural networks obeying the Systems Biology Markup Language (SBML) standard. Over the last 20 years, the systems biology community has developed a large number of mechanistic models in SBML that are currently stored in public databases. With the proposed framework, existing SBML mechanistic models may be upgraded to hybrid systems through the incorporation of deep neural networks into the model core, using a freely available python tool. The so-formed hybrid mechanistic/neural network models are trained with a deep learning algorithm based on the adaptive moment estimation method (ADAM), stochastic regularization and semidirect sensitivity equations. The trained hybrid models are encoded in SBML and stored back in model databases, where they can be further analyzed as regular SBML models. The application of this approach is illustrated with three well-known case studies: the threonine synthesis model in Escherichia coli, the P58IPK signal transduction model, and the Yeast glycolytic oscillations model. The proposed framework is expected to greatly facilitate the widespread use of hybrid modeling techniques for systems biology applications.
Development of a Novel Anti-CD44 Variant 5 Monoclonal Antibody C44Mab-3 for Multiple Applications against Pancreatic Carcinomas
Authors: Kudo Yuma , Suzuki Hiroyuki , Tanaka Tomohiro , Kaneko Mika K. , Kato Yukinari
Published: February 2023

Pancreatic cancer exhibits a poor prognosis due to the lack of early diagnostic biomarkers and the resistance to conventional chemotherapy. CD44 has been known as a cancer stem cell marker, and plays tumor promotion and drug resistance in various cancers. Especially, the splicing variants are overexpressed in many carcinomas, and play essential roles in the cancer stemness, invasiveness or metastasis, and resistance to treatments. Therefore, the understanding of each CD44 variant (CD44v) function and distribution in carcinomas is essential for the establishment of CD44-targeting tumor therapy. In this study, we immunized mice with CD44v3–10-overexpressed Chinese hamster ovary-K1 (CHO) cells, and established various anti-CD44 monoclonal antibodies (mAbs). One of the established clones (C44Mab-3; IgG1, kappa) recognized peptides of the variant 5-encoded region, indicating that C44Mab-3 is a specific mAb for CD44v5. Moreover, C44Mab-3 reacted with CHO/CD44v3–10 cells or pancreatic cancer cell lines (PK-1 and PK-8) by flow cytometry. The apparent KD of C44Mab-3 for CHO/CD44v3–10 and PK-1 was 7.1 × 10−10 M and 1.9 × 10−9 M, respectively. C44Mab-3 could detect the exogenous CD44v3–10 and endogenous CD44v5 in western blotting, and stained the formalin-fixed paraffin-embedded pancreatic cancer cells, but not normal pancreatic epithelial cells in immunohistochemistry. These results indicate that C44Mab-3 is useful for detecting CD44v5 in various applications, and expected for the application of pancreatic cancer diagnosis and therapy.
Exploring Responses of Glioblastoma Patient-Derived Cell Cultures to Drugs Reveals New Therapeutic Opportunities
Authors: Ciechomska Iwona Anna , Wojnicki Kamil , Wojtas Bartosz , Szadkowska Paulina , Poleszak Katarzyna , Kaza Beata , Jaskula Kinga , Dawidczyk Wiktoria , Czepko Ryszard , Banach Mariusz , Czapski Bartosz , Nauman Pawel , Kotulska Katarzyna , Grajkowska Wiesława , Roszkowski Marcin , Czernicki Tomasz , Marchel Andrzej , Kaminska Bozena
Published: February 2023

Glioblastomas (GBM) are most common, primary brain tumors in adults. Despite advances in neurosurgery, radio- and chemotherapy, the median survival of GBM patients is 15 months. Recent large-scale genomic, transcriptomic and epigenetic analyses have shown the cellular and molecular heterogeneity of GBMs, which hampers the outcomes of standard therapies. We have established 13 GBM-derived cell cultures from fresh tumor specimens and characterized them molecularly using RNAseq, immunoblotting and immunocytochemistry. Evaluation of proneural (OLIG2, IDH1R132H, TP53 and PDGFRα), classical (EGFR) and mesenchymal markers (CHI3L1/YKL40, CD44 and phospho-STAT3), as well as expression of pluripotency (SOX2, OLIG2, NESTIN) and differentiation (GFAP, MAP2, β-Tubulin III) markers revealed the striking inter-tumor heterogeneity of primary GBM cell cultures. Upregulated expression of VIMENTIN, N-CADHERIN and CD44 at mRNA/protein levels suggested increased epithelial to mesenchymal transition (EMT) in most studied cell cultures. The effects of temozolomide (TMZ) or doxorubicin (DOX) were tested in three GBM-derived cell cultures with different methylation status of the MGMT promoter. Amongst TMZ- or DOX-treated cultures the strongest accumulation of apoptotic markers: caspase 7 and PARP were found in WG4 cells with methylated MGMT suggesting that its methylation status predicts vulnerability to both drugs. As many GBM-derived cells showed high EGFR levels, we tested the effects of AG1478, an EGFR inhibitor, on downstream signaling pathways. AG1478 caused decreased levels of phospho-STAT3, thus inhibition of active STAT3 augmented antitumor effects of DOX and TMZ in cells with methylated and intermediate status of MGMT. Altogether, our findings show that GBM-derived cell cultures mimic the considerable tumor heterogeneity and identifying patient-specific signaling vulnerabilities can assist in overcoming therapy resistance, by providing personalized combinatorial treatment recommendations.
Flexitarians in Brazil: Who are They, What do They Eat, and Why?
Authors: Teixeira Carla D. , Marchioni Dirce M. , Motta Virginia W. de L. , Chaves Viviany M. , Gomes Sávio M. , Jacob Michelle C. M.
Published: February 2023

The flexitarian diet, which emphasizes a reduction in meat consumption, has been identified as a crucial factor in transitioning to sustainable food systems that can help combat climate change and improve food and nutritional security, particularly in areas where food choices are abundant. Despite Brazil being a major meat producer, meat consumption among Brazilians has been decreasing in recent years, with a growing portion of the population adopting meat-free and meat-reduced dietary models. In this study, we conducted the first non-industry funded scientific investigation of Brazilian flexitarians, with the goal of characterizing their socio-economic and demographic characteristics, motivations for adopting flexitarianism, frequency of animal-based meat consumption, and main substitutes consumed. Data was collected from 1029 self-identified flexitarians in Brazil. Our findings indicate that the flexitarian food model is primarily adopted by women and is motivated by concerns about the environmental impact of meat consumption, personal health, and animal welfare. Flexitarians were found to have a consumption profile that can be divided into three groups: low (consuming meat 36 times a week), medium (consuming meat 7 times a week), and high (consuming meat 4 times a week). The flexitarian meals pattern is characterized by lower consumption of beef (less than 2 times per week) and higher consumption of chicken (3 times per week) and is supplemented by plant-based protein sources and eggs as the main meat substitutes.
Testing Robustness of Camera Sensor Fingerprint (PRNU) Identification on Smartphones
Authors: Martín-Rodríguez Fernando , Isasi-de-Vicente Fernando , Fernández-Barciela Mónica
Published: February 2023

In the field of forensic imaging, it is important to be able to extract a “camera fingerprint” from one or a small set of images known to have been taken by the same camera (image sensor). Ideally, that fingerprint would be used to identify an individual source camera. Camera fingerprint is based on certain kind of random noise present in all image sensors that is due to manufacturing imperfections and thus unique and impossible to avoid. PRNU (Photo-Response Non-Uniformity) has become the most widely used method for SCI (Source Camera Identification). In this paper, we design a set of “attacks” to a PRNU based SCI system and we measure the success of each method. We understand an attack method as any processing that alters minimally image quality and that is designed to fool PRNU detectors (or, generalizing, any camera fingerprint detector). The PRNU based SCI system was taken from an outstanding reference that is publicly available.
Potential Forage Hybrid Markets for Enhancing Sustainability and Food Security in East Africa
Authors: Junca Paredes Jhon Jairo , Flórez Herrera Jesús Fernando , Enciso Valencia Karen Johanna , Hernández Mahecha Luis Miguel , Triana Ángel Natalia , Burkart Stefan
Published: February 2023

The cattle sector is strategic sector for both the economic development and food security of Africa. However, the low availability and quality of forage puts the most vulnerable population in the field at risk. Hybrid forages have proven to be a real alternative for enhancing both the food security and sustainability of the sector. They are the product of genetic improvements and combine the superior traits of different materials. In 1987, the International Center for Tropical Agriculture (CIAT) began this line of research and together with the private sector various ma-terials have been released until today. Despite their beforementioned potential, forage hybrid adoption levels are still low in Africa, which is related to various factors among which the availability of seeds and planting material stands out. This document analyzes the potential markets for new forage hybrids adapted to the environmental conditions of eastern Africa and partially western Africa. Likewise, an estimation of the commercial value of these markets is provided. The results show a potential market of 414,388 ha for new interspecific hybrids of Urochloa and 528,409 ha for potential hybrids of Megathyrsus maximus, with approximate values of 73.5 and 101.1 million dollars, respectively. Ethiopia, Tanzania, and Kenya have a 70% market share for Urochloa, while South Sudan, Ethiopia, and Tanzania have a 67% share for Megathyrsus maximus. The results will help different actors in decision-making, i.e., regarding private sector investments in forage seed commercialization or public sector incentives supporting adoption processes, and thus contribute to increasing food security and sustainability in the region.
Application Cow Manure and Mychorriza to Physiological of Biduri (Calotropis gigantea)
Authors: Hartati Sri , Samanhudi Samanhudi , Rahayu Muji , Sukardan Mochammad Danny , Rahma Nadia Alifia
Published: February 2023

Biduri (Calotropis gigantea) was a wild plant that had many benefits in the health and textile industries. In the health sector, biduri was used as a herbal plant, while in the textile industry, used as the main raw material. Biduri could be used as a substitute for kapok as the main raw material, therefore it was necessary to develop cultivation technology to met the needs. This research was conducted at the Jumantono Field Laboratory of Faculty of Agriculture UNS, Karanganyar using a factorial Randomized Complete Block Design (RCBD), which consisted of 2 factors, namely cow dung fertilizer, and mycorrhizae. Cow dung fertilizer consists of 0 ton/ha, 10 ton/ha, and 20 ton/ha. Mycorrhizae consisted of 0 grams/plant, 5 grams/plant, 10gram/plant, and 15gram/plant. There were 36 treatment combination that consist of 12 treatment combination repeated 3 times. The interaction between cow dung did not significantly affect all physiological observation variables. The results showed that the application of 20 ton/ha of cow dung fertilizer gave the best results on the width of stomata openings, the rate of photosynthesis, and the rate of transpiration. Inoculation with mycorrhizal fungi had no significant effect on all observations of physiological variables 

Keywords: Calotropis gigantea, cow manure, mycorrhiza, physiological
Genetic Variability of Eggplant (Solanum Melongena L. 'Nasubi') Based on ISSR Markers and Phenotypic Characters
Authors: Shafura Nabila , Rabbani Annas , Daryono Budi Setiadi
Published: February 2023

‘Nasubi’ eggplant seeds have occurred since 2018. In addition, plants that produce fruit phenotypic characters differ from those planted before the planting period in 2018. These three factors cause the decline in harvest rates and the current high increase in production costs. Observation of variations in phenotypic and molecular characters with ISSR molecular markers between seeds before 2018 and after 2018, became the first step for the research team to reveal information on the uniformity of phenotypic and molecular characters in eggplant ‘Nasubi’ from seeds purchased by farmers before 2018 and post-2018. The results of the molecular analysis with ISSR primary molecular markers namely UBC 809, UBC 815, IBC 880, UBC 888, and UBC 892, showed that the six samples had a high similarity index of 90% and resulted in a low polymorphism average of 12%. The results of the phenotypic analysis showed that eggplants from the seeds before 2018 and seeds after 2018 in this study had variations in the character of the leaf tip angle, leaf base, flower crown color, stamen color, young fruit color, fruit curve, and fruit tip shape.
Root Growth Response of Soybean Under Water Deficit
Authors: Aziez Achmad Fatchul , Prasetyo Agung , Paiman Paiman
Published: February 2023

Roots are plant organs that function to absorb water and nutrients from the rhizosphere. If the soil is dry, the roots will be affected first. This study aims to know the response of soybean root to drought stress. This research was arranged in a randomized completely block design (RCBD) with two factors and three replications. The first factor was soil moisture content, which consisted of four levels, e.i., 100, 75, 50, and 25% field capacity. The second factor was the growth stage, which consisted of three kinds, e.i., the vegetative active, flowering time, and seed filling period. The results showed that the soil water content in below 75% field capacity decreased root length, root fresh weight, root dry weight, root volume, and increased shoot root ratio. The seed filling period was more sensitive to water deficiency than the active vegetative and flowering time. The study findings that soybean plants can grow well at 100% field capacity. The practical implication of planting soybeans use a soil moisture content of 100% field capacity.
EFFICIENCY OF INFORMATION TECHNOLOGIES IN INTELLECTUAL PROPERTY MANAGEMENT OF INDUSTRIAL ENTERPRISE
Authors: Pererva Petro , Maslak Olga , Kobielieva Tetiana , Kuchynskyi Vladimir , Illiashenko Sergii
Published: February 2023

The article proves that information technology is the basis for the development of information systems, which are the main information resource thatensures the efficiency of business production systems. The use of computer technology and modern software help to improve the speed and quality ofmanagement decisions in production, intellectual and marketing activities of industrial enterprises. Different types of information systems are used inintellectual property management processes. In the commercial and industrial practice of industrial enterprises and organizations, the main types ofeconomic activity that determine the necessary features of the distribution of information systems are creative, production, financial, marketing andpersonnel activities. Industrial enterprises use intelligent information technologies in the field of intellectual property management in order tomaximize the efficiency of the processes of creation, commercialization and use of intellectual property while minimizing costs. Positive results ofintellectual activity of industrial enterprises are observed in the following spheres and directions: grouping by segments of intellectual and innovativeinformation on incomes and the simplified system of comparison of results increases competitiveness of the enterprise; acceleration of the processesof creation, commercialization and use of intellectual property was directly related to its automation; the centralization of the system of trackingorders for intellectual property allowed to control the maintenance of several departments simultaneously; simplification of production controloccurred as a result of the introduction of a specialized system for developing a report evaluating the work of the organization in the field of creation,commercialization and use of intellectual property; It has become possible to solve business problems in a shorter period of time when usingcomputer systems and electronic document management systems in the creation, commercialization and use of intellectual property.
A FEATURES OF FORMING OF FINANCIAL RESULTS OF AGRICULTURAL ENTERPRISE
Authors: Falchenko Olena , Yatsyna Viktoriia , Kochetova Tetyana
Published: February 2023

In the article essence over of agricultural enterprises is brought after the type of economic activity as a legal entity, the basic type of activity of which is growing and processing of agricultural produce and specific of agriculture, as to the type of economic activity. The financial results of agricultural enterprises as economic category which represents effectiveness of activity of agricultural enterprise are considered. General methodology of determination of financial results of agricultural activity is analysed on accordance to the real model of market economy.  The existent substantial features of forming of financial results in agricultural enterprises, which are predefined by the accepted legislative base, at which biological assets and regulated order of their confession, estimation and account are certain and accordingly which the constituents of financial results of agricultural enterprises, and also features of forming of financial result, belong in agricultural enterprises in connection with the specific of industrial and economic activity of industry, are educed. Composition of profits of agricultural enterprises and composition of charges of agricultural enterprises are considered, due to what an income is determined on every type of activity separately by comparison of profits and charges on agricultural enterprises. The basic internal source of forming of financial results of agricultural enterprises, which is income and her influence on economic activity in agriculture is certain. Substantial influence is marked on a size and forming of financial results of agricultural enterprises of estimation of products on a fair value at primitive confession. The order of methodology of forming of financial results of agricultural enterprises is recommended on the basis of the conducted research at a record-keeping. Drawn conclusion, that forming of financial results of agricultural enterprises is the extraordinarily important aspect of their activity and foresees development of certain organizationally-methodical measures with the aim of creation of integral control system by the income of enterprises.
METHODOLOGICAL RECOMMENDATIONS FOR ASSESSING THE EFFECTIVENESS OF USING THE INTELLECTUAL POTENTIAL OF MACHINE-BUILDING ENTERPRISES
Authors: Marchuk Lesia
Published: February 2023

The machine-building industry plays a leading role in the Ukrainian industry, and the development of machine-building enterprises depends on a number of intellectual factors that need to be assessed. After all, it is with the help of assessment that the development and effectiveness of the use of intellectual potential are analyzed. The intellectual potential of a machine-building enterprise is mostly intangible in nature, therefore it is difficult to measure it, since it is not reflected in accounting or statistical data. However, determining its value is an extremely important process for the development and implementation of the development strategy of a machine-building enterprise, strengthening the competitiveness of its products. Assessment of the quality of intellectual potential is carried out on the basis of a certain number of criteria for each of the components of the potential. A quantitative assessment of the intellectual potential of an industrial enterprise involves the use of certain units of measurement. They can be specific values suitable for evaluating components, or conditional indicators (scores, coefficients, indices). However, the numerical values do not fully reflect the qualitative characteristics of the components of the intellectual potential of a machine-building enterprise, which can be obtained by analyzing the indicators in dynamics. Today, there are a large number of methods that can be used to assess the intellectual potential of a machine-building enterprise, but at the same time there is no single generally accepted assessment methodology that will allow Ukrainian enterprises not only to occupy a worthy place in the world market, but also to effectively develop and use intellectual potential. Therefore, the issues of assessing the intellectual potential of machine-building enterprises are very acute and require further research. The article created and substantiated its own scientific and methodological recommendations for assessing the effectiveness of the use and development of intellectual potential.
BUSINESS ECONOMY: EFFICIENT USE OF FIXED ASSETS
Authors: Aleksandrova Viktorija , Chaika Tatiana , Korotkikh Natalia
Published: February 2023

The basis of all production are the objects of fixed assets. When considering the structure of fixed capital, they occupy the largest share. Rational use of fixed production assets has a positive impact on profit and labor productivity. With optimal use of fixed assets there is an acceleration of their turnover. Acceleration of turnover significantly contributes to addressing the issues of reducing the gap in the timing of physical and moral wear and tear, as well as accelerating the pace of their renewal. Analysis of the efficiency of fixed assets is an important problem, because fixed assets are an essential element of the economic potential of any organization, and their analysis is necessary to improve production efficiency. Fixed assets constitute the production power of enterprises, act as an indicator of their technical equipment, directly related to the efficiency of labor resources, mechanization and automation of the production process, input intensity of production and its profitability level. In this connection, the analysis of ways of effective use of the basic means take the basic place in the work of the enterprises. The article analyzes the problem of rational use of fixed assets, as well as ways to improve the use of basic funds by the enterprise. The relevance of the theme of the article is due to the fact that fixed assets are an integral part of any business entity, without them you can not run the business. The aim of the article are recommendations for using ways to improve the efficiency of fixed assets on the basis of a comprehensive analysis of the works of domestic and foreign scientists, whose research is devoted to the study of this problem. The article presents a review of the concept of «fixed assets» by both scientists’ economists and the legal framework.
STRATEGIC MANAGEMENT OF MARKETING ACTIVITIES OF THE ENTERPRISE REGARDING THE FORMATION AND IMPLEMENTATION OF COMMODITY POLICY
Authors: Raiko Diana , Fedorenko Irina , Sokol Kateryna , Lanko Helena
Published: February 2023

The purpose of this article is to determine the strategic management of marketing product policy in the enterprise, as a since the strategic management of control and coordination of marketing product policy of the enterprise allows you to create a model of its implementation in the enterprise in accordance with goals and objectives. The role of marketing in strategic management is manifested at all levels of the enterprise management hierarchy, as it forms and substantiates the concept of meeting consumer needs and provides input to identify attractive market opportunities and assess the potential of the enterprise. Finally, within each individual strategic area of the enterprise, marketing activities help to develop strategies for performing tasks. That is, marketing product policy is the basis of strategic management, which requires a systematic approach. Based on the strategic goals of the company and the mechanism of implementation of marketing product policy, we can proceed to the planning of product range and the formation of the optimal product range.In this paper the theoretical bases were considered, on the basis of the analyzed literature sources own definitions were offered and the difference between commodity policy and marketing commodity policy was formulated. The first extends and focuses on the activities of an individual enterprise, the second, in turn, allows you to globally assess the set of decisions within the market behavior of the enterprise among existing competitors and the target segment of consumers. The algorithm of strategic planning of marketing activities for the implementation, control and coordination of marketing product policy of the enterprise, proposed in the work, allows to solve problems and coordinate and control holistically and fully, understanding the sequence and relationships. The practical implementation of the proposed definitions is the improvement of marketing goals, which are realized precisely through the strategic management of marketing activities in general, which is necessary in the implementation of the enterprise.
DEVELOPMENT OF MEASURES TO IMPROVE THE FORMATION OF CONTROL AND ANALYTICAL INFORMATION ABOUT THE FIXED EQUIPMENT FOR MANAGING THE ACTIVITIES OF THE ENTERPRISE
Authors: Iershovа Natalia , Rybakova Daria , Holovchenko Natalia , Ryzhikova Natalia
Published: February 2023

The article proposes directions for improving the organization and methods of generating control and analytical information for managing fixed assets at an enterprise. The importance of information support for management in the context of the latest economic challenges has been substantiated. Properly organized control is essential for enterprise management. The need for constant interaction between accounting and internal control for the formation of control and analytical information about fixed assets is noted. Fixing the results of work for a certain period, accounting and reporting data create an information database both for monitoring and making subsequent planning and other decisions. Based on the method of logical generalization, the main stages of control and analytical work at the enterprise are proposed, which allows you to streamline and formalize the necessary procedures and determine the responsible persons. The developed test of internal control of fixed assets accounting improves the practical implementation of the proposed measures. This study noted the importance of taking an inventory. For this purpose, information sources have been streamlined to ensure internal control of fixed assets in accordance with the stages of analytical and control work. Also, attention is focused on the basic methods of inventory. A working document "Control over the assignment of fixed assets to assets" has been developed. The use of this internal document contributes to a clearer regulation of control and analytical procedures for fixed assets and can be used in the preparation of internal regulations at the enterprise. The organization of the formation of control and analytical information for the management of fixed assets at the enterprise makes it possible to achieve the efficiency and effectiveness of financial and economic activities.
FORMATION OF THE SMALL BUSINESS ENTERPRISE'S OWN BRAND
Authors: Gorovyi Dmytro , Pavllovskyy Vladislas
Published: February 2023

In a market economy, the buyer's decision to purchase a product affects not only its availability in the market, price, quality, but also the popularity of the manufacturer. Therefore, the issue of the development of the marketing communications system, especially the policy of creating a brand, is becoming especially relevant. More often, the transformation of their name into a brand is used by large firms and enterprises, and the issue of creating and popularizing a brand for small businesses has practically not been considered in the literature. The purpose of this work is to systematize the theoretical provisions and substantiate practical recommendations for developing a brand for small businesses.Trust has been identified as the primary driver of success for small business brands, as brands with a high level of trust can take advantage of young demographic groups willing to try new things, be adventurous and uphold their values. There are two goals of creating a brand of a small enterprise: with the aim of moving from a small enterprise to a large one, or for separating a small enterprise from similar ones operating in the given market. The paper proposes a general algorithm for creating and popularizing a small business brand in Ukraine.In general, the image characteristics of a small business brand should be considered as the main one for the consumer. The most important of them are: the image of the enterprise as a whole (including the attitude of consumers towards its owner or management), the availability, timing and quality of performance of warranty obligations for the goods, the manufacture of goods using modern (or environmentally friendly) technologies.A small enterprise, when creating a brand, should not forget about its financial assessment, since in this case, the brand is an intangible asset of the enterprise, and it is the subject of amortization. In addition, there is a possibility of exercising the rights to a brand in all markets (or in part of the markets) to another enterprise in order to increase financial receipts during crisis periods of the enterprise's operation. Therefore, the further direction of the study is the development of a model for the financial assessment of the brand of a small business enterprise.
FORMATION OF AN EFFECTIVE SYSTEM MOTIVATION PERSONNEL ON THE BASIS OF COMPETENCE MODELS
Authors: Kuchynskyi Volodymyr , Gutsan Oleksandr
Published: February 2023

The role of the competence approach in personnel management as the only methodological basis for the implementation of personnel processes, which will increase efficiency, create competitive advantages and increase the level of competitiveness of the enterprise as a whole. The competency approach provides ample opportunities to describe the type of behavior and those aspects that are necessary to achieve a high level of efficiency of the work process, which allows you to develop a system that combines the requirements of business and personnel management. Personnel selection, evaluation, development and motivation are interrelated processes. In the competence approach, this relationship has found a technological embodiment. It is determined that motivation is a function of personnel management, which forms the efficiency of personnel use. The main advantage of competency-oriented motivation is its developmental component. An approach to staff motivation based on the model of competencies has been formed, which is to develop and improve the permanent part of remuneration based on grading, and the variable part of the personnel motivation system based on KPI. Grading is an assessment of the work performed in each position on the basis of key groups of factors that are considered the most important for the operation and development of the business. Grading positions is based on the evaluation and ranking of positions according to the criteria, which are professional competencies that determine the requirements for the employee for a particular position. The competency approach can be used in the calculation of allowances and the distribution of bonuses using so-called key performance indicators (KPI), which can also be used as professional competencies for specific positions. In addition, within the competence approach it is possible to rationally use not only tangible but also intangible methods of staff motivation. The use of competency models in the system of staff motivation with proper information and appropriate regulatory support allows the company to implement the principles of objectivity and understanding of the goals of the organization to all employees.
DEVELOPMENT OF UKRAINE IN THE ASPECT OF "MAINTAINING" OF THE EFFECTIVE LEVEL OF ITS ECONOMIC SECURITY
Authors: Garmash Sergii
Published: February 2023

The purpose of the article is to analyze open sources of information in order to systematize information to analyze the situation that has developed in Ukraine over the years of independence in the context of aspects of activities for the sake of "maintaining" the most effective level of economic security; identification of negative trends in the development of Ukrainian society and the presentation of practical recommendations to prevent further destruction of statehood. For thirty years of independence, it has been proven that Ukraine has two main enemies: 1) foreign speculative capital; 2) the local oligarchy, which serves this very capital for the sake of its own preferences, being on the criminal offshore "hook" of these very foreign "partners" who are cynically and systematically tearing the country apart and robbing its people. The main interconnected derivatives from these "enemies" and even already components of the process of transforming the country from a subject into an object of foreign influence are: 1) lack of professionalism at all levels of moral and intellectual degraders, who all these years have been trying to get to the state trough for the sake of their own preferences, posing as "statists", with the full support of foreign "partners"; 2) moral and intellectual impoverishment of representatives of the Ukrainian government at all levels, who act in their own "pocket" interests at the expense of the interests of ordinary citizens of Ukraine during the cynical robbery of the country by several local oligarchic clans and foreign monopolies for the purpose of their own enrichment. During the years of independence, there has been a lot of talk by representatives of the authorities and the oligarchy about the successes of the country's "development", but modern realities confirm the opposite thought. Political events of recent months show that Ukraine should have its own state interests: American investments, European technologies and Russian markets are important for the country. Until the Ukrainian oligarchs and those who serve their interests in power understand that they should not make their country and their people "consumables" for the sake of the interests of outside players, until then the country will not have a chance for its independent development in the future.
Research on Strategies of Easing Burden and Increasing Efficiency in Junior High School English Class Based on the Background of Double Reduction
Authors: Hanqi LI
Published: February 2023

Under the environment of a “double reduction” policy, the concept of reducing the burden and increasing efficiency is of practical significance to constructing efficient classrooms, easing students’ excessive homework burdens and improving teaching quality for teachers. Frontline teachers, as implementers and promoters of the “double reduction” policy, innovate teaching methods from the mode of the layered teaching, homework management mechanism, language environment and assessment ways through interpreting the “double reduction” policy and combining it with the existing problems in junior high school English classroom. These ways ensure that students learn well in class and achieve the goal of reducing excessive academic burdens on students and increasing teaching efficiency for teachers.
Medical and demographic indicators of the population older than working age in the conditions of pension reform in the Russian Federation
Authors:   National Research Institute of Public Health named after N. A. Semashko, Kalininskaya A. A. ,   State budgetary institution of the city of Moscow “Scientific Research Institute of Health Organization and Medical Management of the Department of Health of the City of Moscow”, Vasiliev M. D. ,   National Research Institute of Public Health named after N. A. Semashko,   State budgetary institution of the city of Moscow “Scientific Research Institute of Health Organization and Medical Management of the Department of Health of the City of Moscow”, Lazarev A. V. ,   National Research Institute of Public Health named after N. A. Semashko, Kizeev M. V. ,   National Research Institute of Public Health named after N. A. Semashko
Published: February 2023

Purpose of the study. Based on the study of medical and demographic indicators and analysis of the incidence of the population, develop recommendations for the health protection of the population older than working age in the context of the transition to pension reform. Materials and methods: sociological, statistical, direct observation. The materials of the Federal State Statistics Service and statistical materials of the TsNIIOIZ of the Ministry of Health of Russia for 2012–2021 were used. Results. The mortality rate of the population older than working age in the Russian Federation (2020) amounted to 4408,1‰oo, the total population – 1460,2‰oo, in the federal districts of the Russian Federation the indicators fluctuated 1,2 times: from 3818,7‰oo in the North- Caucasian Federal District to 4638,6‰oo in the Volga Federal District, in the subjects of the Russian Federation the difference is 3 times. The indicator of primary morbidity of the studied contingent in the Russian Federation (2020) was 57041,4‰oo, in the Federal District the difference in indicators is 1,25 times, in the constituent entities of the Russian Federation – 3,9 times. The incidence of COVID‑19 in 2020 was 4373,9‰oo, in the Federal District the difference in indicators is 2,2 times, in the subjects of the Russian Federation it is large – 10,6 times, which allows us to conclude that the coding of COVID‑19 is ambiguous. Comparative analysis of the primary incidence of the study population by disease classes in 2019 and 2020 showed an increase in the indicator by 8,9% due to respiratory diseases by 40,8%, the incidence of COVID‑19 in 2020 was 4357,6‰oo. In all other classes, the indicators decreased as a result of a decrease in dispensary and preventive work. During the period of analysis in people older than working age, the increase in the primary morbidity rate is higher – 8,9% than in the total population – 5,7%, which indicates the need to strengthen dispensary and preventive work with the older population. The article gives recommendations on the health protection of the population older than working age.
Bronchitis in children’s populations of different countries, risk factors
Authors:   The City Polyclinic No. 219 of the Moscow City Health Department, Valeev V. V. , Mingazova E. N. ,   N. A. Semashko National Research Institute of Public Health, Kanchukoev Z. I. ,   Medical Information and Analytical Center of the Ministry of Health of the Kabardino-Balkar Republic, Mingazov R. N. ,   N. A. Semashko National Research Institute of Public Health, Smbatyan S. M. ,   N. A. Semashko National Research Institute of Public Health
Published: February 2023

The issues of etiology, clinical presentation, distribution, diagnosis and treatment of bronchitis, as one of the most common respiratory diseases among children, are of considerable research interest. Risk factors for bronchitis are considered meteorological indicators (wind speed and direction, anomalies in relative humidity and atmospheric pressure, a decrease or increase in temperature), environmental pollution (tobacco smoke, NO2 and PM10), immune dysfunctions, preterm birth, exclusive breastfeeding for ≤ 4 months of life. Currently, a significant place in the research literature is occupied by the issues of acute, protracted bacterial and plastic bronchitis in children. Acute bronchitis is mainly caused by a viral infection, mainly rhinovirus, enterovirus, influenza A and B viruses, parainfluenza, coronavirus, human metapneumovirus and respiratory syncytial virus, with bacteria detected in 1–10% of cases. Protracted bacterial bronchitis, isolated as a clinical diagnosis since 2006, can occur in up to 88,5% of cases in children with chronic wet cough, wheezing and airway deformities, more often in children under 6 years of age and males. Prolonged bacterial bronchitis is mainly caused by the bacteria Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis. It is believed that recurrent bronchitis (>3 episodes/year) and the presence of H. influenzae infection in the lower respiratory tract may be significant risk factors for bronchiectasis Plastic bronchitis, a rare disease, in the pediatric population is associated with cardiothoracic surgery (Fontaine operation), infections (viruses influenza, Mycoplasma pneumoniae, tuberculosis, adenoviruses, in particular serotype 7), inflammatory and allergic diseases, acute chest syndrome and iatrogenic processes.