bluuebunny/crossref_metadata_2025 huggingface dataset:
Healthy live birth following ICSI with retrograde ejaculated cryopreserved sperm
Authors: Barkat Neelam , Ahmed Maria , Khan Safdar , Iqbal Anila , Paul Sadia
Published: February 2020

Background: Retrograde ejaculation is a medical condition that occurs when semen enters the urinary bladder(retrograde) during orgasm instead of passing through the penis (antegrade). Complete retrograde semen flow causes male infertility. An advanced technique intracytoplasmic sperm injection (ICSI) can be used to achieve fertilization in the case of male sub-fertility e.g. Oligo-Astheno-Teratozoospermia.

Case Presentation: A couple with primary infertility visited the concept fertility centre, where male was diagnosed with retrograde ejaculation for which ICSI was offered with back-up semen freezing after an initial semen analysis.

Management & Results: Female was stimulated with long stimulation protocol and thirteen matured eggs were injected by cryopreserved sperms extracted from urine sediment. Fertilization occurred in twelve eggs out of which two good quality embryos were transferred after day five in vitro culturing and rest were vitrified. The patient conceived triplets and gave birth at 33 weeks, but two babies had neonatal death within four days and the patient has one healthy baby girl.

Conclusion: Applying assisted reproductive techniques to aid pregnancy in cases of retrograde ejaculation has paucity of knowledge in Pakistan and this case report is the first in Pakistan to describe the diagnosis and successful treatment of infertile couples, with advanced reproductive technology, where the male partner suffered from retrograde ejaculation.
2.7 Machine Learning on Central Hemodynamic Quantities Using Noninvasive Measurements: How Far Can We Go?
Authors: Bikia Vasiliki , Pagoulatou Stamatia , Stergiopulos Nikolaos
Published: February 2020

Background

Transforming peripheral noninvasive measurements to obtain central hemodynamic quantities, such as cardiac output (CO) and central systolic blood pressure (cSBP), is a highly emerging field [1,2]. However, no holistic investigation has been performed to assess the amount of information contained in each peripheral measurement for the prediction of central values. This can be attributed to the inherent difficulty of creating a complete and accurate database; mainly due to the invasive nature of the gold standard techniques [3,4].

Methods

To meet this need, we exploit synthetic data from a previously validated cardiovascular model (CVm) [5]. Our study relies on peripheral quantities including brachial pressure, heart rate (HR), and pulse wave velocity (PWV) simulated by the CVm. A Random Forest model was trained using 2744 synthetic instances and, subsequently, was tested against a subset of 800. Correlations and feature importances of the input parameters were reported (Figure 1).

Results

Our results demonstrated that precise estimates of CO and cSBP were yielded with an RMSE of 0.39 L/min and 1.39 mmHg, respectively (Figures 2 and 3). Low biases were observed, namely 0.03 ± 0.39 L/min for CO and −0.08 ± 1.39 mmHg for cSBP. PWV, HR, and brachial pulse pressure were found to be the most correlated features with CO, whereas brachial SBP was plausibly shown to be the significant determinant of cSBP for our model (Figures 4 and 5).

Conclusion

These findings pave the way for better devising central hemodynamics’ predictions. In the future, our ultimate goal is to examine the sensitivity of cardiac parameters estimation (i.e., elastance) to noninvasive peripheral measurements.
RESILIENSI NAFKAH RUMAH TANGGA DI PULAU KECIL (STUDI KASUS DI NEGERI PAPERU PULAU SAPARUA PROPINSI MALUKU)
Authors: Patty Yeanette S , Pattiselanno August E , Kakisina Leunard O
Published: February 2020

Pendapatan petani di pulau kecil tidak menentu karena aktivitas ekonominya bergantung pada musim, sehingga melakukan aktivitas ganda, baik usaha pertanian maupun luar pertanian.  Masalahnya, kajian mengenai bagaimana tingkat resiliensi rumah tangga dalam menghadapi pola nafkah ganda di pulau kecil masih terbatas dilakukan. Penelitian ini bertujuan untuk menganalisis resiliensi nafkah rumahtangga masyarakat pesisir di pulau kecil. Penelitian dilakukan menggunakan pendekatan kualitatif, dengan jumlah informan 58 orang yang dipilih secara sengaja. Hasil penelitian menunjukkan strategi nafkah yang dikembangkan petani di Negeri Paperu dilakukan melalui tiga cara yaitu mengembangkan usahataninya dengan komoditas cengkeh dan pala, nelayan, dan usaha luar pertanian seperti berdagang dan usaha warung dimana  sebagian besar rumahtangga memiliki resiliensi yang tergolong tinggi.  Hal ini ditunjukkan dengan kemampuan melakukan dinamisasi strategi nafkah, dari kegiatan ekonomi on-farm, ke off-farm, bahkan non-farm.
The Territorial Expansion of Vilnius: Plans and their Realisation (1916–1940)
Authors: Stravinskienė Vitalija
Published: February 2020

The paper analyses the territorial expansion of Vilnius in the first half of the 20th century, based on archival and historiographic material. The ‘grand’ plan for Vilnius’ expansion that the German government started realising during the years of the First World War continued into the ‘Polish’ (1919–1939) and ‘Lithuanian’ (1939–1940) stages of the city’s development. The author concentrates not just on the government’s decisions to geographically expand the city, but also on the ethnic demographic structure of the day, its changes, and how it related to the territorial expansion of Vilnius.
UPAYA MENGURANGI MISKONSEPSI PADA PEMBELAJARAN FISIKA MELALUI MODEL PEMBELAJARAN INKUIRI (INQUIRY LEARNING)
Authors: Aprilia Ayu Amelia , Nana
Published: February 2020

The purpose of this paper is to describe how the effort to reduce misconceptions in Physics learning material using inquiry learning models. This writing is motivated by the large number of students who are still experiencing errors in understanding Physics learning materials. For this reason, efforts need to be made to reduce misconceptions in learning physics. The inquiry learning model can be used to reduce students' misconceptions. The method used in this paper is the study of literature by studying some literature to be analyzed and made conclusions. The results of this paper show that using inquiry learning models in the physics learning process can be a solution to reduce the misconception of material in the classroom. The inquiry learning model is applied to students where when the activity takes place the teacher is only a guide who directs the students then the students actively seek and understand the learning, generating ideas to find solutions in solving existing problems. Learning can increase student activity in the classroom so that not only accept all the material provided by the teacher but actively seek for themselves and there is openness where learning will facilitate the various hypotheses of students that must be proven and its truth openly.
The Crisis of Masculinity for Gendered Democracies: Before, During and After Trump
Authors: Ferree Myra Marx
Published: February 2020

The mobilized masculinity of democracies today is often presented as either a natural way for men to respond to the economic and political challenges of globalization or as a return to the patriarchal style of politics of the past. This paper argues instead for an understanding of liberal democracy itself as gendered, being the collective masculinity of brotherhoods representing rivalrous nations. The first great transition from patriarchies and monarchies to brotherhoods and democracies is not being unmade now but facing a second transition to a different understanding of gender and power. This normative rise of a partnership model in families and politics is incomplete and highly contested everywhere. In the U.S., it has become a partisan conflict expressed in gender terms. The Republican defense of the brotherhood state and its exclusive version of national good is countered by a newer but increasingly institutionalized vision of democracies as representing women and men equally. By more explicitly de-masculinizing family headship and political leadership, social justice movements and the Democratic Party symbolically resist the restoration of gender norms privileging breadwinners and brotherhoods.
A Semi-Structured Approach to Sketch Mapping and Qualitative GIS
Authors: Prener Chris
Published: February 2020

Sketch mapping provides an intuitive means for collecting respondents’ impressions about space and place alongside qualitative data collection approaches. However, the data collected are often challenging to work with, particularly with digitization and visualization. After reviewing these challenges, this article introduces a “semi-structured” approach to sketch map data collection, digitization, and analysis as well as an open source software package, “qualmap,” that implements tools for digitizing these data in the programming language R. This approach retains the cartographically accurate base maps used in other sketch map research. However, it superimposes an areal unit of the researchers’ choice to aid in digitization and analysis. This use of a standard areal unit opens up additional cartographic and analytic possibilities with sketch map data. After describing this approach and the accompanying software, this article illustrates its applicability with a sample project that analyzes perceptions of space collected from a convenience sample of college students. The resulting maps’ clustering identifies the presence of a “bubble” around their campus that captures much of the travel activity students engage in every week. These data are paired with crime data, which illustrates possible mixed methods extensions of this “semi-structured” approach to sketch mapping.
The changing practice of rioting: Revisiting repertoire transitions in Britain, 1800-1939
Authors: Tiratelli Matteo
Published: February 2020

This paper uses a systematic catalogue of 414 riots in Liverpool, Glasgow and Manchester to examine the changing practice of rioting from 1800 to 1939. Three empirical findings emerge: first, over this period, riots went from being an autonomous tactic to one which was largely subordinated to other protest logics; second, the way rioters chose their targets changed: instead of targeting individuals with whom rioters had concrete relationships, they started targeting people as tokens of some wider type; third, throughout this period rioting was a localised practice which reflected local traditions and dynamics. On the basis of these findings, I revisit the orthodox history of social movements and suggest we refine this narrative to explicitly acknowledge continuity in the repertoire of contention, regional variation, the uneven reach of the state and to properly distinguish between individual practices like demonstrations, composite forms like social movements and the repertoire as a whole.
The Value of Certified Pre-Owned Vehicles for Lexus of Edmonton
Authors: Kasawski Trisha L , Singh Sunaina , Bhullar Kanwarbir , Sidhu Gurman , Bath Gurman
Published: February 2020

Our objective was to discover productive improvements to Lexus of Edmonton’s (LoE) current Certified Pre-Owned (CPO) Vehicle practices by determining if CPO vehicles added value, and if so, what value was added. By utilizing multiple methods, we discovered areas in the used vehicle sector that Lexus of Edmonton could improve on. In order to conduct our research, five in-depth interviews, scholarly article evaluations, meet with the representatives of Lexus of Edmonton, and surveys were conducted using paper, email and social media tools such as Google surveys, Twitter and Facebook. The methods allowed our group to utilize statistical analysis to outline the importance of relationships between variables with the statistical software, SPSS. With the information received from statistical analysis, we believe that Lexus of Edmonton can succeed with the sale of CPO vehicles by following our recommendations, including: certification education, appropriate pricing of used vehicles, building trust, value-added certification benefits based on willingness to spend and targeted demographics, as well as further research.
BASIC DEMOGRAPHIC AND MIGRATION PROCESSES IN THE KARACHAY-CHERKESSKY REPUBLIC
Authors: Temirdasheva D.M. , Laipanov R.S.
Published: February 2020

This article is devoted to the study of the main goals and objectives of demographic development in the region on the example of the Karachay-Cherkess Republic. The author identified priority areas in the field of health promotion, increasing life expectancy and migration.
Between 'Greatness' and 'Ignorance'
Authors: Topçu Sezin
Published: February 2020

Focusing on Turkey’s nuclearisation process, which has accelerated over the past decade, this article examines the historical and contemporary relationships that the country’s political decision-makers maintain with risk, the environment and health and ecological disasters. While the transition to nuclear power in the post-Fukushima period is not a dynamic specific to Turkey, it nevertheless operates, in the Turkish case, in a particular geographic, energy and political context. On the one hand, Turkey is a highly seismic country that heavily depends on its neighbours for energy and, on the other, is experiencing a creeping political authoritarianism. This article focuses on the dynamics and specificities of this post-disaster nuclear transition, which will be analysed here as ‘serene nuclearism’, positioned as the polar opposite of ‘reflexive modernisation’, as theorised by Ulrich Beck.
Migration and Redefining Self
Authors: Saidi Saideh
Published: February 2020

This article explores how Afghan (Hazara) women negotiate and sift
their religious understandings and identities over time after migrating to Germany. Migration experiences and exposure to German society has impacted their self-narration and conceptualisation of cultural change in their own identity. This ethnographic research illustrates the notion of acceptance or rejection to change among Hazara immigrant women in their lived religion in diaspora. Based on my fieldwork, three different trajectories along religious lines occur in the Afghan diaspora: a group of immigrants, enhancing Islamic values, whose relationship to and involvement in religion intensified and increased; the second group largely consider themselves secular Muslims trying to fully indulge into the new society; the third group has an elastic religious identity, blending Islamic values with Western-inspired lifestyles.
Examining Various Interpretations of Grice's Cooperative Principle
Authors: Dwi Tirta Syafitri Yona , Budiarti Vira , Simamora Afriyanti , Aprilya Rizka
Published: February 2020

This study aims to examine various interpretations of the principle of cooperation. The principle of cooperation (CP) was first proposed by H.P. Grice in a series of lectures given in 1967. Grice's most influential contribution to linguistics was his theory of implicature. He illustrated that communication follows what he calls the Cooperative Principle (CP) and argues that the fundamental assumption we make when we speak is that we try to work together to build meaningful conversations (1975). The principle of Grice's Cooperation has become controversial in pragmatics. The main source of controversy related to CP is that the term "cooperation" is open to different interpretations. This article uses descriptive qualitative methods. As for the results of the study of this article, the principle of cooperation has always tended to focus too much on the term 'cooperation', rather than looking at and examining the principle titles for motivation given by Grice to the mechanisms that he has identified.
Hubungan indeks massa tubuh dengan kejadian anemia pada remaja putri di SMP Negeri 14 Mataram
Authors: Harahap Ana Pujianti , Pamungkas Catur Esty , Amini Aulia , Nopitasari Nurul
Published: February 2020

Latar belakang: Anemia adalah keadaan tubuh dimana tidak cukup mengandung hemoglobin (Hb) di dalam darah. Anemia pada remaja putri sampai saat ini masih cukup tinggi, data hasil Riskesdas tahun 2013 menunjukkan prevalensi anemia di Indonesia sebesar 21,7%. Persoalan penurunan kadar Hb di negara berkembang berkaitan dengan krisis ekonomi, terjadinya kurang energi protein yang terwujud dengan rendahnya indeks massa tubuh (IMT) dan lingkar lengan atas (LILA), serta asupan sumber zat besi rendah. Tujuan penelitian: Diketahuinya hubungan antara indeks massa tubuh dengan anemia pada remaja putri di SMKN 4 Mataram. Metode: Desain penelitian menggunakan penelitian deskriptif korelatif dengan rancangan cross sectional study. Populasi penelitian ini adalah siswi kelas VII yang menderita anemia SMPN 14 Mataram yaitu 47 orang. Jumlah sampel 47 remaja putri yang diambil secara total sampling. Data yang digunakan adalah data sekunder. Data dianalisis dengan menggunakan uji Chi Square dengan tingkat kesalahan (ɑ = 0,05). Hasil: Terdapat 29 responden (62%) tergolong ke dalam IMT normal, 42 orang (89%) mengalami anemia ringan. Hasil uji chi square nilai P-Value = 0,876 (0,8760,05). Simpulan: Tidak ada hubungan antara indeks massa tubuh dengan anemia pada remaja putri di SMPN 14 Mataram.
Faktor yang berhubungan dengan stunting pada balita di wilayah kerja Puskesmas Air Bangis kabupaten Pasaman Barat
Authors: Anggraini Yuliza , Nusantri Rusdi Pagdya Haninda
Published: February 2020

Latar belakang: Data Riskesdas menunjukkan prevalensi stunting di Indonesia meningkat dari 35,6% pada tahun 2010 menjadi 37,2% pada 2013. Provinsi Sumatera Barat menempati urutan ke 17 dari 34 provinsi stunting di Indonesia dengan prevalensi anak balita (usia 24-59 bulan) stunting 36,2% lebih tinggi daripada prevalensi nasional 35,3%. Prevalensi stunting di Pasaman Barat adalah 51,54% dan jumlah anak stunting adalah 23.435. Tujuan penelitian: Diketahui faktor penyebab terjadinya stunting pada balita di wilayah kerja Puskesmas Air Bangis Kabupaten Pasaman Barat. Metode : Jenis penelitian adalah cross-sectional dengan pendekatan kuantitatif. Populasi adalah seluruh balita yang datang ke Posyandu di wilayah kerja Puskesmas Air Bangis. Jumlah sampel adalah 200 balita dipilih secara purposive sampling. Data yang digunakan adalah data primer dengan metode wawancara dan observasi. Instrumen menggunakan lembar checklist. Hasil: Sebagian besar balita berjenis kelamin laki-laki (57,5%), sebagian besar ibu balita memiliki pendidikan sekolah menengah pertama (48,5%) dan bekerja sebagai IRT (95,5%) dengan jumlah anak 3-5 orang (67%), sebagian besar balita memiliki tinggi badan normal (66%) dengan status gizi baik ((55,5%). Sebagian besar responden memiliki pola asuh baik balita dengan tinggi badan tidak stunting (37,5%), sebagian besar responden yang memanfaatkan posyandu memiliki balita dengan tinggi badan tidak stunting (36,5%) namun sebagian besar responden memiliki sanitasi lingkungan dan memiliki balita stunting (23%). Simpulan: Sebagian besar responden memiliki pola asuh yang baik memiliki balita tidak stunting 37,5%, sebagian besar responden yang memanfaatkan Posyandu memiliki balita tidak stunting yaitu 36,5% dan sebagian besar responden dengan sanitasi lingkungan yang tidak baik dengan balita stunting 23%.
FAKTOR-FAKTOR YANG MEMPENGARUHI SUBTIPE GEJALA MOTORIK PENYAKIT PARKINSON
Authors: Istarini Attiya , Syafrita Yuliarni , Susanti Restu
Published: February 2020

Background: Parkinson's disease (PD) is a chronic neurodegenerative disease that manifests as movement disorders. Based on motor symptoms, PD is classified into subtypes of tremor and postural instability gait disorders (PIGD). The motor symptoms subtype is a predictor of disease progression, therapeutic response, and quality of life for Parkinson's patients. The purpose of this study is to identify some  factors that influence motor symptoms in Parkinson's disease.Methods: This research use cross sectional design. Samples were selected by consecutive sampling method that met the inclusion and exclusion criteria. Research subjects were 58 people. Statistical analysis using SPSS. p values <0.05 were considered statistically significant.Results: This research include 58 patients, 55.2% were men with range of age 63.5 ± 8.5 years old. The mean age at onset was 57.9 ± 9.5 years and duration of disease 6.1 ± 4.6 years. Motor symptoms 53.4% dominant tremor. There was a significant relationship between disease stage and motor symptom subtypes (p <0.001). There is no relationship between the patient's age, age at onset and duration of the disease with motor symptom subtypes.Conclusions: There is a relationship between disease stage and motor symptom. The patient's age, age at onset and duration of the disease are not related to the motor symptoms of Parkinson's patients.
Is the Tongue an “Alternative Donor Site for Anterior Urethroplasty”?
Authors: Md Asaduzzaman - , Islam Md waliul , Hooda Md Nurul , Hossain Tohid Md Saiful , Islam Md shariful , Salam Md Abdus , Rashid Enamul , Bhuiyan AKMZI , Siddique Abu Bakar
Published: February 2020

Objective: To evaluate the effectiveness of a lingual mucosal graft (LMG) urethroplasty for long segment (>2cm) anterior urethral strictures.
Materials and Methods: A total of 30 patients underwent urethroplasty for anterior urethral strictures using dorsal onlay of a LMG from January 2009 to December 2010. We selected 21 to 56 years old (mean age 36.6). Stricture length was 22 to 59 mm (mean 36); 14 strictures were in the bulbar urethra, 09 were in the proximal penile and 07 were in both bulbar and penile urethra. Postoperatively all patients were followed with urethrography, uroflowmetry, cystourethrography and urethroscopy after 3weeks, 3 months and 06 months. Successful reconstruction criteria were peak flow rate greater than 15 ml per second and no need for postoperative urethral dilation.
Results: The mean period of follow-up was 9 months (range 4-12). The overall success rate at 3rd week and 3rd month was 96.7% and at 6th month was 90%. Three patients developed repeat stricture at the anastomotic site. All the patients were able to resume oral fluid within 24 h, eat soft solid diet in 48–72 h and return to normal diet after 4– 5 days of surgery. No patient suffered from difficulty in opening the mouth, salivation disturbances, or difficulty in protrusion of tongue.
Conclusions: LMG is easy to harvest. LMG seems to be associated with less postoperative pain and a minor risk of donor site complications or without any functional or esthetic deficiency. The tongue may be the best alternative donor site.
Bangladesh Journal of Urology, Vol. 15, No. 1, Jan 2012 p.11-14
Hubungan Faktor Pendukung Customer Relationship Manajemen dengan Loyalitas Pasien Poli Interna Ratulangi Medical Centre
Authors: Burhanuddin Nurfardiansyah , Suyuti Sartika
Published: February 2020

Customer Relationship Management bertujuan untuk proses adaptasi antara klinik dengan pelangganya. Jadi klinik manapun sebenarnya bertanggung jawab menjalankan program Customer Relationship Management, setiap devisi, setiap klinik dan setiap petugas pelayanan harus mengetahui tentang program tersebut, tujuan-tujuannya, dan yang paling penting apa peranan mereka dan bagaimana mereka dapat memberikan kontribusi dalam menjalankan program itu.  Berdasarkan uraian diatas maka perlu dilakukan penelitian yang bertujuan mengidentifikasi Hubungan Faktor Pendukung Customer Relationship Management (CRM) dengan Loyalitas Pasien di Poli Interna Klinik Ratulangi Medical Centre (RMC) Kota Makassar. Penelitian ini merupakan penelitian kuantitatif menggunakan survey analik dengan rancangan cross sectional study yaitu suatu rancangan penelitian yang mempelajari hubungan antara variabel independen (Petugas pelayanan, Proses pelayanan, Teknologi pelayanan) dengan variabel dependen (Loyalitas pasien). Populasi penelitian ini adalah kunjungan pasien di poli interna Klinik Ratulangi Medical Centre (RMC) Kota Makassar yang menggunakan pelayanan kesehatan tahun 2017, yaitu sebanyak 1296 pasien dengan jumlah sampel 117 pasien. Metode pengumpulan sampel dilakukan dengan cara random sampling. Berdasarkan hasil uji statistik diperoleh masing masing nilai petugas pelayanan p=0,559, proses pelayanan p=0,740, dan teknologi pelayanan p=0,760. Semua variable tidak berhubungan faktor Customer Relationship Management (CRM) dengan loyalitas pasien di poli interna klinik Ratulangi Medical Centre (RMC). Hal ini dapat dilihat dengan keputusan tingkat loyalitas pasien sebagian besar melihat aspek petugas pelayanan yang dimiliki klinik Ratulangi Medical Centre (RMC). Menyangkut petugas pelayanan sebagian besar pasien setuju bahwa petugas mampu memberikan kemampuan, keterampilan, dan keramahan kepada pasien di Poli Interna Klinik Ratulangi Medical Centre (RMC). Proses pelayanan sebagian besar pasien setuju bahwa proses pelayanan mudah untuk lakukan. Membantu petugas untuk lebih mengenali dan menjalin hubungan dekat dengan pasien. Dimensi proses terbentuk karena identifikasi profil, komunikasi dengan pelanggan, dan penanganan keluhan pasien di Poli Interna Klinik Ratulangi Medical Centre (RMC). Teknologi pelayanan, beberapa pasien setuju bahwa teknologi pelayanan mudah untuk mendapatkan informasi, membantu mempercepat dan mengoptimalkan faktor manusia dan proses bisnis dalam aktivitas pengelolaan hubungan dengan pasien di Poli Interna Klinik Ratulangi Medical Centre (RMC). Kesimpulan dari penelitian bahwa tidak terdapat hubungan faktor pendukung Customer Relationship Management (petugas pelayanan, proses pelayanan, dan teknologi pelayanan) dengan loyalitas pasien di poli interna klinik Ratulangi Medical Centre (RMC) Kota Makassar tahun 2018.
Pengontrolan Diet Pasien Yang Didiagnosis Dengan Diabetes Mellitus Sebagai Dasar Program Konseling
Authors: Mutmainna Amriati
Published: February 2020

Kondisi kesehatan seseorang yang mengalami diabetes mellitus akan dialami seumur hidup oleh pasien yang menderita diabetes mellitus yang serius dimana terjadi ketika jumlah glukosa dalam darah terlalu tinggi. Tujuan dari penelitian ini adalah analisis faktor yang mempengaruhi penilaian kontrol diet pasien dengan diabetes mellitus untuk mengusulkan program konseling. Desain penelitian yang digunakan adalah survei deskriptif dengan pendekatan cross sectional study. 72 responden diambil sebagai subjek dalam penelitian ini. Frekuensi, persentase, nilai rata-rata, dan uji chi-square digunakan untuk mengolah data kuantitatif pada penelitian ini. Peringkat penilaian untuk pengontrolan diet dalam penelitian ini berkisar dari derajat sangat tinggi, derajat tinggi, derajat sedang, hingga derajat rendah. Hasil penelitian menunjukkan bahwa tidak ada perbedaan yang signifikan pengontrolan diet menurut usia, jenis kelamin, dan riwayat merokok. Namun, ada perbedaan yang signifikan pada pengontrolan diet responden ketika dikelompokkan sesuai dengan kadar gula darah dan indeks massa tubuh. Penilaian kontrol makanan ini melalui Diabetes Mellitus Self-Management Questionnaire (DSMQ) dengan melihat pengontrolan dietnya, maka dianggap sebagai pendekatan yang efektif untuk mengatasi berbagai kondisi pasien diabetes mellitus melalui program konseling. Kesimpulan penelitian bahwa perilaku pengontrolan diet dari responden memiliki pengaruh pada kadar gula darah. Disarankan agar pasien diabetes mellitus mengontrol makanan karena dapat membantu pasien untuk mengontrol gula darah dalam batas normal.
Development of the Composition and Technology of New Neuroprotective Drug Tablets Using Fractional Factorial Design
Authors: Terenteva O. A. , Flisyuk E. V. , Ivkin D. Yu. , Narkevich I. A.
Published: February 2020

Introduction. The creating an effective and safe domestic neuroprotective medicines with a complex of pleiotropic effects realized through specific orphan receptors (SUCNR1, HCA2) of glial cells, is a pressing problem of modern pharmacology and a promising possibility of pharmacotherapy of brain injury and cerebrovascular diseases. Ideally, the medicine should helps restore lost cognitive functions and physical performance after damage to the central nervous system, and its use should improve the quality of life of patients and reduce the risk of complications.

Aim. To develop composition and technology of a new medicine tablets with neuroprotective effect, using fractional factorial design of experiment and the Harrington desirability function.

Materials and methods. The shape and size of particles, physicochemical (solubility, melting point) and technological properties (bulk density, compressibility factor, fractional composition, hygroscopicity) of the pharmaceutical substance of DEAE derivative were studied according to the methods described in the State Pharmacopoeia of the Russian Federation (14th edition). A three-factor fractional plan based on the 4 × 4 Latin square design for selection a scientifically based composition of solid dosage form was chosen. 16 experiments to test the significance of the factors were carried out. The tablets obtained according to the planning matrix were investigated for disintegration; tablet crush resistance, friability, and hygroscopicity. To optimize the quality of the tablets, the generalized Harrington desirability function was used.

Results and discussion. The study of the physicochemical and technological properties of the DEAE derivative substance showed that it is a highly hygroscopic, amorphous, white or pale yellow, odourless powder, prone to the formation of agglomerates. The powder is very easily soluble in water. Taking into account the values of the general desirability function, the best result was shown by sample № 4 consisting of mannitol, calcium stearate, and partially pregelatinized maize starch.

Conclusion. The physicochemical and technological properties of the DEAE derivative were studied. The DEAE derivative is a highly hygroscopic substance. Via the method of mathematical planning of the experiment the composition of DEAE derivative tablets was selected and scientifically grounded: DEAE derivative 60 mg, mannitol, partially pregelatinized maize starch, calcium stearate. The average tablet weight is 300 mg. The parameters of pressing tablets were selected.
Peptide-Targeted Polymer Cancerostatics
Authors: BÖHMOVÁ E. , POLA R.
Published: February 2020

A tumor-targeting drug delivery system consists of a tumor recognition moiety and a directly linked cytotoxic agent or an agent attached to a water-soluble synthetic polymer carrier through a suitable linker. Conjugation of a drug with a polymer carrier can change its solubility, toxicity, biodistribution, blood clearance and therapeutic specificity. Increased therapeutic specificity of a polymer drug can be achieved by the attachment of a targeting moiety (e.g. a lectin, protein, antibody, or peptide) that specifically interacts with receptors on the target cells. A large number of tumor-specific peptides were described in recent years. After a short introduction, some important examples of peptide-targeted conjugates will be described and discussed.
Protein Interactions With Quaternized Chitosan/Heparin Multilayers
Authors: KUMOREK M. , KUBIES D. , RIEDEL T.
Published: February 2020

Understanding the behavior of single proteins at the polyelectrolyte multilayer film/solution interface is of prime importance for the designing of bio-functionalized surface coatings. In the present paper, we study the adsorption of the model proteins, albumin and lysozyme, as well as basic fibroblast growth factor (FGF-2) on a polysaccharide multilayer film composed of quaternized chitosan and heparin. Several analytical methods were used to describe the formation of the polysaccharide film and its interactions with the proteins. Both albumin and lysozyme adsorbed on quaternized chitosan/heparin films, however this process strongly depended on the terminating polysaccharide. Protein adsorption was driven mainly by electrostatic interactions between protein and the terminal layer of the film. The effective binding of FGF-2 by the heparin-terminated film suggested that other interactions could also contribute to the adsorption process. We believe that this FGF-2-presenting polysaccharide film may serve as a biofunctional surface coating for biologically-related applications.
Integrative, Interdisciplinary Database Design for the Spatial Humanities: the Case of the Holocaust Ghettos Project
Authors: Knowles Anne Kelly , Hillebrand Justus , Jaskot Paul B. , Walke Anika
Published: February 2020

Databases are central to the digital, spatial, and geohumanities. There is surprisingly little scholarly literature, however, on the process of database construction in humanities projects. This article describes a process of interdisciplinary database design that emerged in the course of building the core sections of an historical GIS of Holocaust ghettos. The process foregrounds collaborative design, testing that purposely flushes out paradigmatic differences and ontological problems, and revision to incorporate group decisions and agreed-upon meanings into data structures, field definitions, and instructions for data entry. The result is a deeply integrative form of mixed methodology that incorporates ethical standards along with data entry instructions and team training.
Um Breve Olhar nas Fotografias do Ano Revolucionário Cubano nos Livros Didáticos de História do PNLD 2018
Authors: Pérola Dantas Barros Maria Luiza
Published: February 2020

Recebido: 15/10/2019

Aprovado: 27/11/2019

No contexto das comemorações em torno dos 60 anos do ano revolucionário cubano (1959), se faz necessário pensar como que a representação de um fato que, nas palavras de Feitosa (2010) marcaria a história da América Latina no século XX e ainda permanece como referência para os movimentos sociais do século XXI, tem alcançado os estudantes brasileiros. Compreendendo a fotografia a partir de Kossoy (2009), como uma representação a partir do real segundo o olhar e a ideologia de seu autor, e entendendo por representação o proposto por Chartier (1988), no que se refere a este ser um vasto campo que engloba as percepções do social, este artigo tem por objetivo lançar um breve olhar nas fotografias do ano revolucionário cubano, buscando compreender se elas são ou não trabalhadas como fontes nos livros didáticos de História, aprovados pelo Programa Nacional do Livro Didático (PNLD) 2018, a partir da relação de ancoragem da imagem pelo texto proposta por Roland Barthes (1961;1964;1990).

Palavras-chaves: Revolução Cubana. Ano Revolucionário. Fotografias. Ancoragem. Livro Didático de História.
A Inteligência Norte-americana e a Crise dos Mísseis de 1962
Authors: Lima Raquel
Published: February 2020

Recebido: 15/10/2019

Aprovado: 27/11/2019

O objetivo deste artigo é analisar o papel que a inteligência norte-americana, exercida pela Central Intelligence Agency (CIA), teve na Crise dos Mísseis de 1962, em Cuba. Observaremos como foi o processo de descoberta dos mísseis pela agência, quais seus acertos e falhas, e as consequências destas, e que leitura a CIA teve do cenário que se formou entre os EUA, URSS e Cuba. Assim, nossa problemática está voltada para entendermos como foi sua ação e qual sua importância para a política norte-americana. Metodologicamente este trabalho está pautado em uma revisão historiográfica sobre os acontecimentos em envolveram a CIA e a Crise, que serão analisados através de teorias voltadas para agendas de segurança e defesa.

Palavras-chave: Crise dos Mísseis; CIA; Cuba; Inteligência.
Detoxification Impacts of Ascorbic Acid and Clay on Laying Japanese Quail Fed Diets Polluted by Various Levels of Cadmium
Authors: Abou-Kassem Diaa E. , Abd El-Hack Mohamed E. , Taha Ayman E. , Ajarem Jamaan S. , N. Maodaa Saleh , Allam Ahmed A.
Published: February 2020

A total number of 360 laying Japanese quail (8 weeks of age) were randomly divided into 12 groups. Birds in all groups had nearly the same average initial body weight. A factorial arrangement (4 × 3) was performed including four levels of dietary cadmium (Cd) as cadmium chloride (0, 50, 100, and 150 mg/kg diet) and three levels of feed additives (without, 300 mg/kg ascorbic acid and 1.50% natural clay). Results revealed that Cd contaminated feed caused significant (p < 0.01) retardation in body weight, lower egg number and egg mass and worse feed conversion. On the other hand, the addition of ascorbic acid or natural clay to quail diets caused a significant (p < 0.01) improvement in all studied traits. With respect to the interaction among Cd and the experimental additives, results showed that within each Cd level, ascorbic acid or clay supplementation recorded the highest body weight, egg number, egg weight and mass in addition to improved feed conversion. Cadmium levels decreased (p < 0.05) blood total protein, albumen and A/G ratio. Both 300 mg ascorbic acid and 1.50% clay increased (p < 0.05) blood total protein and albumen compared to non-supplemented groups. It could be concluded that the consumption of polluted diets Cd causes deleterious effects on the productive performance of laying Japanese quail. The addition of ascorbic acid or natural clay to the diets causes beneficial effects on productive performance traits, improves egg quality criteria and diminishes the toxic effects of Cd.
Comparative Study of the Effects of GLP1 Analog and SGLT2 Inhibitor against Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms
Authors: Hussein Abdelaziz M. , Eid Elsayed A. , Taha Medhat , Elshazli Rami M. , Bedir Raouf Fekry , Lashin Lashin Saad
Published: February 2020

The present study investigated the possible cardioprotective effects of GLP1 and SGLT2i against diabetic cardiomyopathy (DCM) in type 2 diabetic rats and the possible underlying mechanisms. Methods: Thirty-two male Sprague Dawley rats were randomly subdivided into 4 equal groups: (a) control group, (b) DM group, type 2 diabetic rats with saline daily for 4 weeks, (c) DM + GLP1, as DM group with GLP1 analogue (liraglutide) at a dose of 75 µg/kg for 4 weeks, and (d) DM + SGLT2i as DM group with SGLT2 inhibitor (dapagliflozin) at a dose of 1 mg/kg for 4 weeks. By the end of treatment (4 weeks), serum blood glucose, homeostasis model assessment insulin resistance (HOMA-IR), insulin, and cardiac enzymes (LDH, CK-MB) were measured. Also, the cardiac histopathology, myocardial oxidative stress markers (malondialdehyde (MDA), glutathione (GSH) and CAT) and norepinephrine (NE), myocardial fibrosis, the expression of caspase-3, TGF-β, TNF-α, and tyrosine hydroxylase (TH) in myocardial tissues were measured. Results: T2DM caused significant increase in serum glucose, HOMA-IR, serum CK-MB, and LDH (p < 0.05). Also, DM caused significant myocardial damage and fibrosis; elevation of myocardial MDA; NE with upregulation of myocardial caspase-3, TNF-α, TGF-β, and TH; and significant decrease in serum insulin and myocardial GSH and CAT (p < 0.05). Administration of either GLP1 analog or SGLT2i caused a significant improvement in all studied parameters (p < 0.05). Conclusion: We concluded that both GLP1 and SGLT2i exhibited cardioprotective effects against DCM in T2DM, with the upper hand for SGLT2i. This might be due to attenuation of fibrosis, oxidative stress, apoptosis (caspase-3), sympathetic nerve activity, and inflammatory cytokines (TNF-α and TGF-β).
Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation?
Authors: Mélik Parsadaniantz Stéphane , Réaux-le Goazigo Annabelle , Sapienza Anaïs , Habas Christophe , Baudouin Christophe
Published: February 2020

Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease’s pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recent research suggests that glaucomatous optic neuropathy is a disease that shares common neuroinflammatory mechanisms with “classical” neurodegenerative pathologies. In addition to the death of retinal ganglion cells (RGCs), neuroinflammation appears to be a key element in the progression and spread of this disease. Indeed, early reactivity of glial cells has been observed in the retina, but also in the central visual pathways of glaucoma patients and in preclinical models of ocular hypertension. Moreover, neuronal lesions are not limited to retinal structure, but also occur in central visual pathways. This review summarizes and puts into perspective the experimental and clinical data obtained to date to highlight the need to develop neuroprotective and immunomodulatory therapies to prevent blindness in glaucoma patients.
A Method Based on GA-CNN-LSTM for Daily Tourist Flow Prediction at Scenic Spots
Authors: Lu Wenxing , Rui Haidong , Liang Changyong , Jiang Li , Zhao Shuping , Li Keqing
Published: February 2020

Accurate tourist flow prediction is key to ensuring the normal operation of popular scenic spots. However, one single model cannot effectively grasp the characteristics of the data and make accurate predictions because of the strong nonlinear characteristics of daily tourist flow data. Accordingly, this study predicts daily tourist flow in Huangshan Scenic Spot in China. A prediction method (GA-CNN-LSTM) which combines convolutional neural network (CNN) and long-short-term memory network (LSTM) and optimized by genetic algorithm (GA) is established. First, network search data, meteorological data, and other data are constructed into continuous feature maps. Then, feature vectors are extracted by convolutional neural network (CNN). Finally, the feature vectors are input into long-short-term memory network (LSTM) in time series for prediction. Moreover, GA is used to scientifically select the number of neurons in the CNN-LSTM model. Data is preprocessed and normalized before prediction. The accuracy of GA-CNN-LSTM is evaluated using mean absolute percentage error (MAPE), mean absolute error (MAE), Pearson correlation coefficient and index of agreement (IA). For a fair comparison, GA-CNN-LSTM model is compared with CNN-LSTM, LSTM, CNN and the back propagation neural network (BP). The experimental results show that GA-CNN-LSTM model is approximately 8.22% higher than CNN-LSTM on the performance of MAPE.
Universal Gorban’s Entropies: Geometric Case Study
Authors: Mirkes Evgeny M.
Published: February 2020

Recently, A.N. Gorban presented a rich family of universal Lyapunov functions for any linear or non-linear reaction network with detailed or complex balance. Two main elements of the construction algorithm are partial equilibria of reactions and convex envelopes of families of functions. These new functions aimed to resolve “the mystery” about the difference between the rich family of Lyapunov functions (f-divergences) for linear kinetics and a limited collection of Lyapunov functions for non-linear networks in thermodynamic conditions. The lack of examples did not allow to evaluate the difference between Gorban’s entropies and the classical Boltzmann–Gibbs–Shannon entropy despite obvious difference in their construction. In this paper, Gorban’s results are briefly reviewed, and these functions are analysed and compared for several mechanisms of chemical reactions. The level sets and dynamics along the kinetic trajectories are analysed. The most pronounced difference between the new and classical thermodynamic Lyapunov functions was found far from the partial equilibria, whereas when some fast elementary reactions became close to equilibrium then this difference decreased and vanished in partial equilibria.
Ambient PM2.5 and Annual Lung Cancer Incidence: A Nationwide Study in 295 Chinese Counties
Authors: Guo Huagui , Li Weifeng , Wu Jiansheng
Published: February 2020

Most studies have examined PM2.5 effects on lung cancer mortalities, while few nationwide studies have been conducted in developing countries to estimate the effects of PM2.5 on lung cancer incidences. To fill this gap, this work aims to examine the effects of PM2.5 exposure on annual incidence rates of lung cancer for males and females in China. We performed a nationwide analysis in 295 counties (districts) from 2006 to 2014. Two regression models were employed to analyse data controlling for time, location and socioeconomic characteristics. We also examined whether the estimates of PM2.5 effects are sensitive to the adjustment of health and behaviour covariates, and the issue of the changing cancer registries each year. We further investigated the modification effects of region, temperature and precipitation. Generally, we found significantly positive associations between PM2.5 and incidence rates of lung cancer for males and females. If concurrent PM2.5 changes by 10 μg/m3, then the incidence rate relative to its baseline significantly changes by 4.20% (95% CI: 2.73%, 5.88%) and 2.48% (95% CI: 1.24%, 4.14%) for males and females, respectively. The effects of exposure to PM2.5 were still significant when further controlling for health and behaviour factors or using 5 year consecutive data from 91 counties. We found the evidence of long-term lag effects of PM2.5. We also found that temperature appeared to positively modify the effects of PM2.5 on the incidence rates of lung cancer for males. In conclusion, there were significantly adverse effects of PM2.5 on the incidence rates of lung cancer for both males and females in China. The estimated effect sizes might be considerably lower than those reported in developed countries. There were long-term lag effects of PM2.5 on lung cancer incidence in China.
Role of Perceived Social Support on the Association between Physical Disability and Symptoms of Depression in Senior Citizens of Pakistan
Authors: Tariq Azam , Beihai Tian , Abbas Nadeem , Ali Sajjad , Yao Wang , Imran Muhammad
Published: February 2020

An emerging body of literature has implied that perceived social support is known as an upstream element of cognitive health. Various dimensions of perceived social support may have divergent influence on physical and cognitive health in later life. The present study aimed to investigate the mediating role of perceived social support on the relationship between physical disability and symptoms of depression in senior citizens of Pakistan. The data were collected from three metropolitan cities (Lahore, Faisalabad, Multan) in the Punjab province of Pakistan and 100 participants were approached from each city with a total sample size of 300. The results demonstrated that family support, friends’ support, and significant others’ support mediated the association between physical disability and symptoms of depression, with an indirect effect of 0.024, 0.058, and 0.034, respectively. The total direct and indirect effect was 0.493. Physical disability was directly associated with symptoms of depression and greater physical disability predicted a higher level of symptoms of depression. Perceived social support, including family support, friends’ support, and significant others’ support, showed an indirect association with symptoms of depression. Furthermore, family support and friends’ support were more significantly associated with symptoms of depression as compared to significant others’ support. The research discoveries have better implications for health care professionals, hospice care workers, and policy makers. A holistic approach is required to prevent senior citizens from late-life mental disorders.