bluuebunny/crossref_metadata_2025 huggingface dataset:
Сonfirmatory study of the efficacy and tolerability of trifluridine/tipiracil (TAS-102) therapy in the Russian population with chemorefractory metastatic colorectal cancer
Authors: Fedyanin M. Yu. , Moiseenko F. V. , Chekini D. A. , Chubenko V. A. , Zhabina A. S. , Zagorskaya L. A. , Kramchaninov M. M. , Tjulandin S. A. , Moiseyenko V. M.
Published: January 2021

Introduction. Trifluridine/Tipiracil (FTD/TPI) is a new chemotherapeutic drug approved in more than 60 countries for use in patients with metastatic colorectal cancer who have registered progression or intolerance to treatment with fluoropyrimidines, oxaliplatin and irinotecan, anti-VEGRand anti-EGFR-targeted agents. This study evaluated for the first time the effectiveness and tolerability of FTD/TPI therapy in the Russian patient population.

Materials and methods. A confirmatory open-label single-arm non-randomized trial was conducted in 2 clinical centres in Russia. The main criteria for inclusion were: conduction of at least the 2nd line of standard systemic therapy for metastatic colon adenocarcinoma. The primary efficacy criteria were: 2-month progression-free survival; secondary – median progressionfree survival, disease control frequency, safety assessment, overall survival. Research number: NCT03274882.

Results. A total of 26 patients were included in the study; the median age was 60.5 years (30 to 78); 19 (73%) women; and 4 patients with ECOG 0 and 22 – with ECOG 1. All patients were previously treated with the inclusion of oxaliplatin, irinotecan, fluoropyrimidines, 21 (81%) – bevacizumab, 6 (23%) – anti-EGFR antibodies, and 2 (7.7%) – regorafenib. The median for treatment courses was 4 (1–21), 11 (42.3%) patients were treated for 6 months or more. The two-month progression-free survival rate was 52% with a median progreesion-free survival rate of 4 months (95% CI 1.8–7.4 months). The median of total survival rate was 11 months (95% CI 5,2–16,8 months). Disease control was achieved in 60%. Neutropenia, nausea, vomiting, anemia, weakness prevailed among undesirable events associated with treatment (≥5 patients). The majority of complications were of the 1st–2nd degree. Among the undesirable events of the 3rd–4th degree, neutropenia was more common, while in 3 patients febrile neutropenia of the 3rd degree was registered.

Conclusions. In the Russian population of patients with colorectal chemorefractory cancer, the drug FTD/TPI (TAS-102) shows efficacy and tolerability comparable to the RECOURSE registration study.
Boas práticas na manutenção do cateter intravenoso periférico
Authors: Estequi Jeanine Geraldin , Roseira Camila Eugenia , De Jesus Josélia Batista , De Figueiredo Rosely Moralez
Published: January 2021

Objetivo: Avaliar o índice de conformidade da equipe de enfermagem às boas práticas de manuseio do cateter intravenoso periférico, no âmbito hospitalar. Método: estudo descritivo-exploratório, prospectivo, de abordagem quantitativa, desenvolvido no município de São Carlos – São Paulo, onde foi observado, utilizando-se instrumento norteador, as ações relativas ao manuseio do cateter intravvenoso periférico, no período de dezembro de 2017 à março de 2018. Todos os aspectos éticos foram contemplados. Resultados: Foram observados 435 cateteres. A identificação estava correta em 350 (80,5%) dos acessos venosos e a fixação apresentou aspecto inadequado em 79 (18,2%) casos. Verificou-se presença de rubor em 5 (1,2%), edema/infiltração em 2 (0,4%) e sangue no conector duas vias em 167 (38,4%) dos cateteres observados. Conclusão: As complicações encontradas, apesar de representarem pequeno número da amostra, indicam ainda práticas de não conformidade na manutenção do cateter endovenoso periférico.
Boas práticas de Enfermagem na Unidade de Terapia Intensiva: Desenvolvendo o Histórico de Enfermagem
Authors: Santos Marisa Gomes dos , Silva Tatiana Gaffuri da , Da Silva Alexsandra Martins , Bitencourt Júlia Valéria de Oliveira Vargas , Nascimento Eliane Regina Pereira do , Bertoncello Katia Cilene Godinho
Published: January 2021

Objetivo: Analisar o significado da prática do histórico de enfermagem em uma Unidade de Terapia Intensiva. Método: Estudo qualitativo, realizado em uma Unidade de Terapia Intensiva do sul do Brasil, com nove enfermeiros. A coleta de dados ocorreu por meio de grupo de discussão, tendo como questão disparadora: O que significa a prática do Histórico de Enfermagem na Unidade de Terapia Intensiva? Os dados foram analisados por meio do Discurso do Sujeito Coletivo. Resultados: O estudo deu origem a três discursos com as ideias centrais: O histórico de enfermagem representa a qualificação do cuidado e o empoderamento da enfermagem; A informação como ferramenta do cuidado; O instrumento utilizado para o histórico de enfermagem como construção coletiva. Considerações Finais: O histórico de enfermagem como boa prática confere à profissão, autonomia, empoderamento e visibilidade. Ademais, qualifica e assegura o cuidado oferecido respaldando o exercício profissional.
Representações Sociais de Mães sobre o Cuidado ao Filho com Câncer
Authors: Bomfim Eliane dos Santos , Oliveira Bruno Gonçalves de , Boery Rita Narriman Silva de Oliveira
Published: January 2021

Objetivo: Apreender as representações sociais de mães sobre a condição de ter um filho com câncer. Método: Pesquisa qualitativa, fundamentada no referencial Teórico das Representações Sociais. Realizada em uma Unidade de Tratamento Oncológico, com 19 mães de criança com diagnóstico de câncer, através da técnica projetiva desenho-estória com Tema e a entrevista semiestruturada, em janeiro a março de 2016. Resultados: Após análise dos dados, emergiram asseguintes categorias temáticas: Impacto do câncer infantil; e processo de enfrentamentos de mães ao filho com câncer, sendo que esta última categoria se desdobrou em duas subcategorias: A espiritualidade no processo de enfrentamento da doença; e Apoio familiar e social no processo da doença. Conclusão: O estudo evidenciou que os cuidados específicos das mães expressos através da proteção, afeto e amor visam atender as necessidades ao filho com câncer. Essa experiência de cuidar traz dificuldades ocasionadas pela adaptação à nova realidade social.Descritores: Cuidado; Mãe; Criança; Câncer; Representação.
Rede de suporte social e tecnologias de cuidados para idosos com deficiência
Authors: Reis Girondi Juliana Balbinot , Bittencourt Rosa Line , Fernandez Darla Lusia Ropelato , Schier Jordelina , Tristão Francisco Reis , Hammerschmidt Karina Silveira de Almeida
Published: January 2021

Objetivo: investigar as redes de suporte social da pessoa idosa com deficiência e as tecnologias inovadoras de cuidado implementadas à pessoa idosa com deficiência e de suporte ao cuidador. Método: pesquisa exploratório-descritiva de abordagem qualitativa, realizada no período de abril a outubro de 2016. Participaram 26 instituições não governamentais. Realizou-se aplicação de entrevista semiestruturada; empregada Análise Temática para tratamento dos dados. Resultados: Evidenciou-se que estratégias como grupos de convivência, grupos de apoio, arte como terapia e atividades de lazer podem ser considerados tecnologias de cuidado. Destacou-se a forma como as famílias estão sendo preparadas para cuidar do idoso com deficiência, já que uma parcela não possui cuidador ou apresenta rede de suporte familiar insuficiente. Conclusão: observou-se a necessidade reflexão quanto a expansão de serviços que visam a integração social do idoso com deficiência, sendo a criação de centros-dia para esta clientela, uma delas.
Construção e validação da escala “Avaliação da compreensão do paciente sobre orientações de alta”
Authors: Jaure Bacury Souza Mota Rednaj , Puggina Ana Claudia Giesbrecht
Published: January 2021

Objetivo: Construir e investigar as propriedades psicométricas de uma escala que avalia a compreensão do paciente sobre orientações de alta. Metodologia: Estudo metodológico quantitativo realizado com 72 pacientes e dois observadores. A validação foi obtida por meio da análise fatorial e correlação intra-classe. A consistência interna foi verificada pelo Alpha de Cronbach. Resultados: A escala foi construída em duas partes: a parte I (14 itens) refere-se a compreensão referida e é respondida pelo paciente, a parte II (8 itens) refere-se a compreensão percebida e é respondida por um observador. A consistência interna foi considerada excelente (α=0.918) na parte I e aceitável na parte II tanto para observador 1 (α=0.724) quanto para o observador 2 (α=0.749). A reprodutibilidade inter-observador foi aceitável (r=0.824). A análise fatorial da parte I determinou quatro fatores: (1) compreensão sobre medicamentos; (2) compreensão sobre tratamento e diagnóstico; (3) compreensão sobre restrição e (4) compreensão sobre retorno. Conclusão: A escala “Avaliação da compreensão do paciente sobre orientações de alta” foi considerada confiável e válida.
Os Profissionais de Enfermagem merecem mais que aplausos
Authors: Farias Veronica Egline , Lira Geison Vasconcelos
Published: January 2021

Objetivo: refletir acerca dos aplausos dirigidos aos profissionais de Enfermagem na “linha de frente” do combate à COVID-19. Método: artigo de opinião a partir das reportagens na mídia a respeito dos aplausos à Enfermagem, apesar da crescente precariedade de trabalho nos serviços públicos de saúde, nos últimos anos. Resultados: evidenciou-se a disparidade entre este gesto de gratidão, a escassez de recursos e carga de trabalho exaustiva, que tem se intensificado ainda mais neste contexto. Conclusão: Para além de apoio psicológico e social, é necessário também maior investimento na Saúde, para diminuir concretamente o risco de infecção que vem sendo enfrentado pelos profissionais devido à falta de recursos apropriados para seu trabalho.Descritores: Enfermagem; Infecções por Coronavírus; COVID-19.  NURSING PROFESSIONALS DESERVE MORE THAN APPLAUSEObjective: to reflect on the applause addressed to Nursing professionals on the “front line” of the fight against COVID-19. Method: opinion article based on media reports about applause for Nursing professionals, despite the growing precariousness of work in public health services in recent years. Results: the disparity between this gesture of gratitude, the scarcity of resources and an exhaustive workload became evident, which has intensified even more in this context. Conclusion: in addition to psychological and social support, greater investment in health is also needed to concretely reduce the risk of infection that professionals are facing due to the lack of appropriate resources for their work. Descriptors: Nursing; Coronavirus infections; COVID-19.  PROFESIONALES DE ENFERMERÍA MERECEN MÁS QUE APLAUSOSObjetivo: reflexionar sobre los aplausos dirigidos a los profesionales de enfermería en la “primera línea” de la lucha contra COVID-19. Método: artículo de opinión desde los medios informativos sobre los aplausos para Enfermería, a pesar de la creciente precariedad del trabajo en los servicios de salud pública en los últimos años. Resultados: se hizo evidente la disparidad entre este gesto de gratitud, la escasez de recursos y una carga de trabajo exhaustiva, que se ha intensificado aún más en este contexto. Conclusión: además del apoyo psicológico y social, también se necesita una mayor inversión en Salud para reducir concretamente el riesgo de infección que enfrentan los profesionales debido a la falta de recursos apropiados para su trabajo. Descriptores: Enfermería; Infecciones por Coronavirus; COVID-19.
Cuidados multiprofissionais relacionados à prevenção da pneumonia associada à ventilação mecânica
Authors: Liz Janaina Souza de , Gouvea Pollyana Bortholazzi , Acosta Adriano Da Silva , Sandri Juliana Vieira de Araújo , Paula Dagoberto Mior de , Maia Silmara Costa
Published: January 2021

Objetivo: Conhecer a percepção da equipe multiprofissional acerca dos cuidados relacionados às medidas de prevenção a pneumonia associada à ventilação mecânica. Método: Tratou-se de um estudo descritivo, qualitativo em que participou a equipe multiprofissional atuante em UTI. Resultados: Totalizaram 20 profissionais. Verificou-se que a equipe multiprofissional conhece algumas medidas preventivas, no entanto a enfermagem percebe o fisioterapeuta como protagonista neste processo. Conclusões: A pesquisa permitiu identificar a maneira como cada membro da equipe percebe a sua atuação e a atuação do outro.Palavras-chave: Infecção Hospitalar; Enfermagem; Controle de Infecções Objective: To know the perception of the multidisciplinary team about the care related to the prevention measures against ventilator-associated pneumonia. Method: This was a descriptive and qualitative study in which the multiprofessional team working in Intensive Care Unit participated. Results: Totaled 20 professionals. It was found that the multiprofessional team knows some preventive measures, however nursing refers to the physical therapist as a protagonist in this process. It was also noticed that the nurse has a fundamental role in maintaining care before the multiprofessional team. Conclusions: The study showed that the multiprofessional team demonstrates knowledge about the preventive measures related to ventilator-associated pneumonia, as well as the professionals seek to act continuously to improve the quality of care, aiming to ensure patient safety.Descriptors: Hospital Infection; Nursing; Infection Control. Objetivo: Conocer la percepción del equipo multidisciplinario sobre la atención relacionada con las medidas de prevención contra la neumonía asociada al ventilador. Método: Este fue un estudio descriptivo y cualitativo en el que participó el equipo multiprofesional que trabajaba en la Unidad Intensiva. Resultados: totalizaron 20 profesionales. Se encontró que el equipo multiprofesional conoce algunas medidas preventivas, sin embargo, la enfermería se refiere al fisioterapeuta como protagonista en este proceso. También se notó que la enfermera tiene un papel fundamental en el mantenimiento de la atención ante el equipo multiprofesional. Conclusiones: El estudio mostró que el equipo multiprofesional demuestra conocimiento sobre las medidas preventivas relacionadas con la neumonía asociada al ventilador, así como que los profesionales buscan actuar continuamente para mejorar la calidad de la atención, con el objetivo de garantizar la seguridad del paciente.Descriptores: infección hospitalaria; Enfermería; Control de infecciones.
Empreendedorismo na Enfermagem: uma necessidade para inovações no cuidado em saúde e visibilidade profissional
Authors: Santos José Luís Guedes , Bolina Alisson Fernandes
Published: January 2021

O empreendedorismo não é apenas uma competência importante para a busca de uma prática autônoma, mas também uma característica que potencializa a prática dos profissionais de enfermagem no cuidado às pessoas e coletividades. Por meio do empreendedorismo empresarial, intraempreendedorismo e empreendedorismo social o enfermeiro pode contribuir para inovações no cuidado em saúde em saúde e, por conseguinte, ampliar a visibilidade da profissão.
Avaliação da dimensão estrutura para a qualidade da Atenção Primária à Saúde
Authors: Barreto Raissa Mont'Alverne , Albuquerque Izabelle Mont’ Alverne Napoleão , Cunha Isabel Cristina Kowal Olm , Freitas Cibelly Aliny Siqueira Lima , Braga Jamilly Coelho Teixeira , Dos Santos Lima Rayanne Branco
Published: January 2021

Este estudo objetivou avaliar a qualidade da dimensão estrutura das Unidades Básicas de Saúde de Sobral, Ceará, a partir do referencial de Donabedian. Trata-se de estudo avaliativo com abordagem quantitativa, realizada em novembro de 2018 a janeiro de 2019. Para coleta dos dados aplicou-se uma adaptação do Instrumento de Avaliação de Serviços de Atenção Básica com 18 gerentes e 46 equipes de saúde da família. Para análise dos dados foram utilizadas técnicas de estatística descritiva a partir da tabulação, processamento dos dados e produção de tabelas. Observou-se ausência em 17% das unidades de banheiro adaptado; ausência em 100% das unidades de desfibrilador; 83% delas referiram ausência de veículo para uso rotineiro de atividades pelos profissionais e constatou-se acesso regular de 78% para medicamentos de Hipertensão e apenas 61% para Diabetes. Conclui-se que a estrutura das unidades precisa ser valorizada para qualificar as ações desenvolvidas na Atenção Primária à saúde.Descritores: Atenção à saúde; Avaliação em saúde; Atenção Primária à Saúde.
Enfermagem em práticas avançadas no atendimento pré-hospitalar: oportunidade de ampliação do acesso no Brasil
Authors: Malvestio Marisa Aparecida Amaro , Behringer Lilian Prates Prates Belém , Martuchi Sérgio Dias , Fonseca Marcos Aurélio da Silva , Da Silva Luciano , De Souza Eduardo Fernando , Hanszman Gilson Clementino , Bezerra Rildo
Published: January 2021

O objetivo é analisar o cenário de implementação da EPA no atendimento pré-hospitalar (APH) como ferramenta de acesso ao cuidado de urgência no Brasil. Metodologia: Frente ao cenário das urgências, foi realizada análise da literatura relacionada a EPA e seus resultados, bem como investigação não-exaustiva sobre a participação do enfermeiro no APH em outros países, com vistas a explorar o impacto da introdução de enfermeiros na urgência pré-hospitalar no Brasil. Conclusão: A ampliação do papel dos enfermeiros no modelo brasileiro de APH pode viabilizar o alcance da cobertura 100% e incrementar a capacidade de avaliação e  a realizaçãode procedimentos em tempo adequado,  assegurando acesso oportuno ao cuidado. Decs: Serviços Médicos de Emergência; Prática Avançada de Enfermagem; Assistência à Saúde
Withdrawal Notice: TP53 Targetome: A Database of Novel Breast Cancer Biomarkers
Authors: Hameed Yasir , Ejaz Samina
Published: January 2021

The article has been withdrawn from the journal “Current Drug Targets” on behalf of the editor’s request. Bentham Science apologizes to its readers for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publishers that manuscripts submitted to this journal should not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and while submit- ting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers, if and when the article is accepted for publication.
Forecasting of Covid-19 Cases Using Machine Learning Approach
Authors: Kumar Sachin , Veer Karan
Published: January 2021

Aims:

The objective of this research is to predict the covid-19 cases in India based on
the machine learning approaches.

Background:

Covid-19, a respiratory disease caused by one of the coronavirus family members,
has led to a pandemic situation worldwide in 2020. This virus was detected firstly in Wuhan city of
China in December 2019. This viral disease has taken less than three months to spread across the
globe.

Objective:

In this paper, we proposed a regression model based on the Support Vector Machine
(SVM) to forecast the number of deaths, the number of recovered cases, and total confirmed cases
for the next 30 days.

Method:

For prediction, the data was collected from Github and the ministry of India's health and
family welfare from March 14, 2020, to December 3, 2020. The model has been designed in
Python 3.6 in Anaconda to forecast the forecasting value of corona trends until September 21,
2020. The proposed methodology is based on the prediction of values using SVM based regression
model with polynomial, linear, rbf kernel. The dataset has been divided into train and test datasets
with 40% and 60% test size and verified with real data. The model performance parameters were
evaluated as a mean square error, mean absolute error, and percentage accuracy.

Results and Conclusion:

The results show that the polynomial model has obtained 95% above accuracy
score, linear scored above 90%, and rbf scored above 85% in predicting cumulative death,
conformed cases, and recovered cases.
Opioid Dependency and Myocardial Infarction: A Systematic Review and Meta-Analysis
Authors: Rohani Farahnaz , Rezayat Arash A. , Zarifian Ahmadreza , Nour Mohammad G. , Vakilian Farveh , Sahebkar Amirhossein , Dadgarmoghaddam Maliheh
Published: January 2021

Background:

Coronary artery disease is a major cause of morbidity and mortality worldwide.
A major health concern in the developing countries is opioid addiction, which has controversial
cardiovascular side effects. We aimed to investigate whether Myocardial Infarction (MI) and its risk
factors are associated with morphine dependency in the Iranian population.

Methods:

Electronic databases, including PubMed, Medline, Scopus, SID, Element, and Magiran
were searched to find published articles including the keywords morphine, coronary artery disease,
hypertension, hyperlipidemia, and diabetes mellitus.

Results:

Twelve studies involving 25,800 people were included in this systematic review and metaanalysis.
Morphine dependency was significantly associated with MI with an adjusted odds ratio
(AOR) of 2.28 (95%CI=1.26-4.11). It neither has significant associations with hypertension
(AOR=0.952; 95%CI=0.696-1.301) nor diabetes (AOR=0.895; 95%CI=0.644-1.246). Morphine dependency
also had no significant association with hyperlipidemia with a Crude Odds Ratio (COR) of
0.906 (95%CI=0.786-1.045).

Conclusion:

Morphine dependency was significantly related to MI, but its risk factors were not significantly
associated with morphine dependency. The increasing prevalence of opioid abuse in developing
countries may be a reason for the growing incidence of MI in younger ages and individuals with
no risk factors. Besides, physicians should consider the presence of impurities in morphine-based opioids
and their possible effects on health.
Dual Human Carbonic Anhydrase/Cyclooxygenase-2 Inhibitors: A Promising Approach for Cancer Treatment
Authors: Mahboubi-Rabbani Mohammad , Zarghi Afshin
Published: January 2021

Human Carbonic Anhydrase (hCA) and Cyclooxygenase-2 (COX-2) have been known for a long to be
chiefly involved in both the pathogenesis and progression of cancer and cancer chemoresistance. Interestingly,
there is considerable evidence that the sulfonamide-type COX-2 selective inhibitors (coxibs) demonstrate
inhibitory action against the cancer-related hCA isoforms, confirmed by X-ray crystal structures for celecoxib
and valdecoxib complexes with the hCA active site. Consequently, the antineoplastic activity of the sulfonamide
coxibs may be justified by the contribution of hCA inhibition to such processes in addition to COX-2 inhibition.
Accordingly, these compounds' anti-tumoral activity should be further explored for their possible use in cancer
prevention and combination therapy; however, few papers deal with this issue. Beginning with a brief description
of the main molecular and catalytic features of both enzymes and their roles in tumor physiology, this review
covers a survey of the most recent evidence regarding the molecules targeting one or both of hCA and COX-2,
besides providing insights into their mechanism of action and efficacy in preventing cancer.
Withdrawal Notice: Comparison of Pharmaceutical Effect of Alemtuzumab and Natalizumab and Their Side Effects in Treatment of Various Stages of Multiple Sclerosis Patients
Authors: Mohammadi Mostafa
Published: January 2021

This article submitted to the journal CNS & Neurological Disorders - Drug Targets; has been withdrawn upon the
request of the author due to the errors and invalid information in the article.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be
simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been
published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is
strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal
right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By
submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and
when the article is accepted for publication.
Comparison of Diagnostic Value between Point of Care Testing (POCT) and Standardize HbA1c Testing in Primary Health Care
Authors: Rudijanto Achmad , Rosandi Rulli , Sasiarini Laksmi
Published: January 2021

Diabetes Mellitus is one of the biggest health problems. HbA1c is used to diagnose, to monitor treatment and treatment adjustment. High Performance Liquid Chromatography (HPLC) and electron spray mass spectrometry are recommended to measure HbA1c. But both methods need expensive cost, facility, and potentially increase health cost burden. HbA1c measurement using Point of Care Testing (POCT) is developed in Indonesia. POCT is more comfortable, has lower cost and easily brought to primary health care. Aim: to assess the clinical efficacy of POCT compared with a standard examination by HPLC. Methods: It is a cross-sectional observational study conducted at a first-level health facility (FKTP) in Malang. The subject population was patients who went to an outpatient unit in FKTP with inclusion criteria aged 20-75 years, were participants in the chronic disease management program (PROLANIS), both diabetes and non-diabetes. Results: Three hundred and thirty eight subjects were participated in this study. Five subjects were excluded because the presence of anemia. We used Wilcoxon test to compare HbA1c level between two methods and Rank Spearman correlation test to find correlation between two methods. This study showed measurement HbA1c level using POCT method had good accuracy (>80%). Other than diagnosis value, increased utilization of POCT HbA1c might also be caused by its portability and patientâ€™s comfort. Conclusions: This study showed a strong correlation (R=0.016) between POCT HbA1c and standardized measurement. POCT HbA1c also showed good accuracy in all HbA1c groups.
Correlation between Risk Stratification of Complications and Types of Antihyperglycemia Drugs with Incidence of Acute Diabetic Complications in Patients with Diabetes Mellitus during Ramadan Fasting
Authors: Sasiarini Laksmi , Simatupang Charisma Dian , Arsana Putu Moda
Published: January 2021

Ramadan fasting for Diabetes Mellitus (DM) patients can lead to acute complications such as hypoglycemia, hyperglycemia, diabetic ketoacidosis (DKA) and thrombosis. Risk stratification predicts fasting safety of DM patients. Dose and timing of antihyperglycemia drugs adjusted during Ramadan fasting. Aim: To know the correlation between the risk stratification of Ramadan fasting and type of antihyperglycemia drugs with the incidence of acute complications in DM patients undergoing Ramadan fasting. Methods: DM patients in Endocrinology Clinic, dr. Saiful Anwar, General Hospital Malang who intend to fast during Ramadan classified in IDF-DAR risk stratification, conduct blood glucose monitoring and filled out a daily logbook during fasting. Results: Thirty-seven subjects were included in the study, only 1 patient with type-1 DM. Average fasting time is 18 days. Acute complications found higher in very high-risk group (5/6) compared to mild/moderate (2/13) and high-risk group (7/18) (p=0.009). Acute complications found higher in group with OAD and insulin combination regiment (2/4) compared to OAD (9/24) or insulin group (3/9) (p= 0. 731). One subject in very high-risk group suffered from acute coronary syndrome. Relationship between risk stratification and the incidence of hypoglycemia (p=0.040) and hyperglycemia (p=0.031) was significant. Relative risk in the very high-risk group was 2.538 compared to mild/moderate risk RR (95% CI)= 0.77 (0.62-0.96). Conclusions: There is a correlations between risk stratification and acute complications in DM patients undergoing Ramadan fasting. No relationship between type of antihyperglycemia drugs with acute complications of Ramadan fasting.
The Effect of Vitamin E on Oral Mucositis Induced by Chemotherapy in Non-Hodgkin Lymphoma Patients Receiving Chemotherapy
Authors: Hermanto Djoko Heri , Habsari Indri , Machsoos Budi Darmawan
Published: January 2021

Chemotherapy-induced mucositis is a side effect of chemotherapy that often occurs in patients with solid tumors and lymphoma. Oral mucositis can affect nutritional status and the risk of infection, both local and systemic. Antioxidant Vitamin E is beneficial for the prevention and therapy of both oral and gastrointestinal mucositis. Aim: To determine the effect of vitamin E therapy on the incidence of oral mucositis in non-Hodgkin lymphoma (NHL) patients receiving chemotherapy. Methods: This is a single-blind experimental study in 62 NHL patients undergoing chemotherapy who meet the inclusion criteria. Patients who met the inclusion criteria were randomly divided into 2 groups, namely 31 patients (treatment group) received vitamin E 400 mg / IU per day for 7 days and 31 patients in the placebo group. The incidence and grade of oral mucositis were observed on day 7. Statistical analysis used Chi-Square and Mann Whitney test according to the data type. Results: a total of 67% NHL patients were male, most of whom were over 46 years of age and as many as 50% of patients used chemotherapy regimens RCHOP and CHOP. There was an incidence of oral mucositis in 35% in the placebo group and 12.9% in the treated group (p = 0.038). In the placebo group, there were 4.8% of patients with grade 2 and 3 oral mucositis, which was not found in the therapy group. Conclusion: Â treatment with vitamin E in NHL patients undergoing chemotherapy can prevent chemotherapy-induced oral mucositis and prevent its severity.
Fork Rib: A Rare Musculoskeletal Etiology of Chest Pain
Authors: Rahman Perdana Aditya , Nasir Aslam Ahmad Bayhaqi
Published: January 2021

Chest pain is a common clinical presentation in daily practice. Musculoskeletal origin is a rare etiology of chest pain, compared to a cardiorespiratory problem and often underrecognized. Fork-rib or bifid-rib is a rare anomaly which uncommonly present with clinical symptoms since in most cases fork-rib incidentally found during cadaveric dissection. Here we report a 27 years old man presenting with chest pain and radiographic examination showing bifid rib of the fifth left rib, without any abnormalities from physical examination and electrocardiography. The patient treated with intravenous painkiller and anticonvulsants. Fork-rib should be considered as a differential diagnosis for chest pain of musculoskeletal origin especially in young adults or chest pain precede with minor trauma.Â
A Food Poisoning Outbreak in Al-Khazir U2 Camp of Internally Displaced Persons - Iraq, Summer 2017
Authors: Kadhim Kamal , Fathallah K , Al Jaafar  , Hamad A , Saadoon S , Awad Z , Lami F
Published: January 2021

Background

Globally, about 600 million fall ill and 420,000 die every year after eating contaminated food. On June 12, 2017, Iraq CDC informed about a food poisoning outbreak among internally displaced persons (IDPs) in Al-Khazir camp, Northern Iraq after consuming “Iftar” (Ramadan breakfast) provided by an NGO. “Iftar” was composed of rice, white bean broth, chicken, yogurt, date and bread.

Objective

The objective was to describe the outbreak, identify the causative agent and recommend preventive measures.

Methods

A team of FETP residents dispatched to investigate the outbreak. The case patient was defined as any person in the camp who ate “Iftar” and developed nausea/vomiting or diarrhea or abdominal pain. A retrospective cohort study was initiated.

Results

Conclusions

The large number of ordered meals from a single restaurant led to suboptimal food preparation and storage. We recommended rigorous implementation of food handing instructions and health education of the food handlers.
Development and Evaluation of a New Serious Game for Continuing Medical Education of General Practitioners (Hygie): Double-Blinded Randomized Controlled Trial
Authors: Jaunay Louis-Baptiste , Zerr Philippe , Peguin Lino , Renouard Léandre , Ivanoff Anne-Sophie , Picard Hervé , Griffith James , Chassany Olivier , Duracinsky Martin
Published: January 2021

Background

Continuing medical education is important but time-consuming for general practitioners (GPs). Current learning approaches are limited and lack the ability to engage some practitioners. Serious games are new learning approaches that use video games as engaging teaching material. They have significant advantages in terms of efficiency and dissemination.

Objective

The aim of this study was to create a serious game and to evaluate it in terms of effectiveness and satisfaction, comparing it with a traditional method of continuing education—article reading.

Methods

We produced a prototype video game called Hygie on the 5 most common reasons of consultation in general practice using 9 articles from independent evidence-based medicine journals (reviews from Prescrire and Minerva). We created 51 clinical cases. We then conducted a double-blinded randomized trial comparing the learning provided by a week of access to the game versus source articles. Participants were GPs involved as resident supervisors in 14 French university departments of family practice, recruited by email. Primary outcomes were (1) mean final knowledge score completed 3 to 5 weeks after the end of the intervention and (2) mean difference between knowledge pretest (before intervention) and posttest (3 to 5 weeks after intervention) scores, both scaled on 10 points. Secondary outcomes were transfer of knowledge learned to practice, satisfaction, and time spent playing.

Results

A total of 269 GPs agreed to participate in the study. Characteristics of participants were similar between learning groups. There was no difference between groups on the mean score of the final knowledge test, with scores of 4.9 (95% CI 4.6-5.2) in the Hygie group and 4.6 (95% CI 4.2-4.9) in the reading group (P=.21). There was a mean difference score between knowledge pre- and posttests, with significantly superior performance for Hygie (mean gain of 1.6 in the Hygie group and 0.9 in the reading group; P=.02), demonstrating a more efficient and persistent learning with Hygie. The rate of participants that reported to have used the knowledge they learned through the teaching material was significantly superior in the Hygie group: 77% (47/61) in the Hygie group and 53% (25/47) in the reading group; odds ratio 2.9, 95% CI 1.2-7.4. Moreover, 87% of the opinions were favorable, indicating that Hygie is of interest for updating medical knowledge. Qualitative data showed that learners enjoyed Hygie especially for its playful, interactive, and stimulating aspects.

Conclusions

We conclude that Hygie can diversify the offering for continuing education for GPs in an effective, pleasant, and evidence-based way.

Trial Registration

ClinicalTrials.gov NCT03486275; https://clinicaltrials.gov/ct2/show/NCT03486275
Smartphone-Detected Ambient Speech and Self-Reported Measures of Anxiety and Depression: Exploratory Observational Study
Authors: Di Matteo Daniel , Wang Wendy , Fotinos Kathryn , Lokuge Sachinthya , Yu Julia , Sternat Tia , Katzman Martin A , Rose Jonathan
Published: January 2021

Background

The ability to objectively measure the severity of depression and anxiety disorders in a passive manner could have a profound impact on the way in which these disorders are diagnosed, assessed, and treated. Existing studies have demonstrated links between both depression and anxiety and the linguistic properties of words that people use to communicate. Smartphones offer the ability to passively and continuously detect spoken words to monitor and analyze the linguistic properties of speech produced by the speaker and other sources of ambient speech in their environment. The linguistic properties of automatically detected and recognized speech may be used to build objective severity measures of depression and anxiety.

Objective

The aim of this study was to determine if the linguistic properties of words passively detected from environmental audio recorded using a participant’s smartphone can be used to find correlates of symptom severity of social anxiety disorder, generalized anxiety disorder, depression, and general impairment.

Methods

An Android app was designed to collect periodic audiorecordings of participants’ environments and to detect English words using automatic speech recognition. Participants were recruited into a 2-week observational study. The app was installed on the participants’ personal smartphones to record and analyze audio. The participants also completed self-report severity measures of social anxiety disorder, generalized anxiety disorder, depression, and functional impairment. Words detected from audiorecordings were categorized, and correlations were measured between words counts in each category and the 4 self-report measures to determine if any categories could serve as correlates of social anxiety disorder, generalized anxiety disorder, depression, or general impairment.

Results

The participants were 112 adults who resided in Canada from a nonclinical population; 86 participants yielded sufficient data for analysis. Correlations between word counts in 67 word categories and each of the 4 self-report measures revealed a strong relationship between the usage rates of death-related words and depressive symptoms (r=0.41, P<.001). There were also interesting correlations between rates of word usage in the categories of reward-related words with depression (r=–0.22, P=.04) and generalized anxiety (r=–0.29, P=.007), and vision-related words with social anxiety (r=0.31, P=.003).

Conclusions

In this study, words automatically recognized from environmental audio were shown to contain a number of potential associations with severity of depression and anxiety. This work suggests that sparsely sampled audio could provide relevant insight into individuals’ mental health.
Factors Contributing to Diagnostic Discordance Between Store-and-Forward Teledermatology Consultations and In-Person Visits: Case Series
Authors: Lee Michelle S , Stavert Robert
Published: January 2021

Background

Use of asynchronous store-and-forward (SAF) teledermatology can improve access to timely and cost-effective dermatologic care and has increased during the COVID-19 pandemic. Previous research has found high diagnostic concordance rates between SAF teledermatology and face-to-face clinical diagnosis, but to our knowledge, none have used specific cases to illustrate factors contributing to diagnostic discordance.

Objective

To identify and illustrate characteristics that may have contributed to diagnostic discordance between store-and-forward teledermatology and in-person clinical diagnosis in a series of patients.

Methods

We identified 7 cases of diagnostic discordance between teledermatology and in-person visits where the favored diagnosis of the in-person dermatologist was not included in the differential diagnosis formulated by the teledermatologist. Cases were identified from a previously published retrospective chart review of 340 SAF teledermatology consultations, which was previously performed at an academic community health care system in the greater Boston area, Massachusetts, from January 1, 2014, through December 31, 2017. Of 99 patients who completed an in-person dermatology appointment after their teledermatology consultation, 7 had diagnostic disagreement between the teledermatologist and in-person dermatologist where the diagnosis in the in-person consultation was not included in the differential diagnosis in the original teledermatology consult. These 7 cases were examined by 2 author reviewers to identify factors that may have contributed to diagnostic discordance.

Results

Factors contributing to diagnostic discordance between SAF teledermatology consultations and in-person visits included poor image quality, inadequate history or diagnostic workup, inability to evaluate textural characteristics, diagnostic uncertainty due to atypical presentations, and evolution in appearance of skin conditions over time.

Conclusions

We identified multiple factors that contributed to diagnostic discordance. Recognition and mitigation of these factors, when possible, may help to improve diagnostic accuracy and reduce the likelihood of misdiagnosis. Continuing education of referring providers and implementation of standardized guidelines for referrals may also be helpful in reducing the risk of misdiagnosis due to inherent limitations of teledermatology services.
Smartphone-Detected Ambient Speech and Self-Reported Measures of Anxiety and Depression: Exploratory Observational Study (Preprint)
Authors: Di Matteo Daniel , Wang Wendy , Fotinos Kathryn , Lokuge Sachinthya , Yu Julia , Sternat Tia , Katzman Martin A , Rose Jonathan
Published: January 2021

BACKGROUND

The ability to objectively measure the severity of depression and anxiety disorders in a passive manner could have a profound impact on the way in which these disorders are diagnosed, assessed, and treated. Existing studies have demonstrated links between both depression and anxiety and the linguistic properties of words that people use to communicate. Smartphones offer the ability to passively and continuously detect spoken words to monitor and analyze the linguistic properties of speech produced by the speaker and other sources of ambient speech in their environment. The linguistic properties of automatically detected and recognized speech may be used to build objective severity measures of depression and anxiety.

OBJECTIVE

The aim of this study was to determine if the linguistic properties of words passively detected from environmental audio recorded using a participant’s smartphone can be used to find correlates of symptom severity of social anxiety disorder, generalized anxiety disorder, depression, and general impairment.

METHODS

An Android app was designed to collect periodic audiorecordings of participants’ environments and to detect English words using automatic speech recognition. Participants were recruited into a 2-week observational study. The app was installed on the participants’ personal smartphones to record and analyze audio. The participants also completed self-report severity measures of social anxiety disorder, generalized anxiety disorder, depression, and functional impairment. Words detected from audiorecordings were categorized, and correlations were measured between words counts in each category and the 4 self-report measures to determine if any categories could serve as correlates of social anxiety disorder, generalized anxiety disorder, depression, or general impairment.

RESULTS

The participants were 112 adults who resided in Canada from a nonclinical population; 86 participants yielded sufficient data for analysis. Correlations between word counts in 67 word categories and each of the 4 self-report measures revealed a strong relationship between the usage rates of death-related words and depressive symptoms (r=0.41, P<.001). There were also interesting correlations between rates of word usage in the categories of reward-related words with depression (r=–0.22, P=.04) and generalized anxiety (r=–0.29, P=.007), and vision-related words with social anxiety (r=0.31, P=.003).

CONCLUSIONS

In this study, words automatically recognized from environmental audio were shown to contain a number of potential associations with severity of depression and anxiety. This work suggests that sparsely sampled audio could provide relevant insight into individuals’ mental health.

CLINICALTRIAL
YouTube Platform and the English Language Learning in the Brazilian Context
Authors: Silva Marcia Aparecida , De Carvalho Junior Izidio Dias
Published: January 2021

This work aims at exploring the YouTube platform as a social network and useful space for English language learning in the Brazilian context. We believe that YouTube is a potential platform to enhance autonomy, but we are aware that there is a specific kind of student who could benefit from using this tool. For the theoretical basis of this research, we are based on Recuero (2009) to discuss the meaning of social network. We will explore some YouTubers who use the platform to teach the English language.
Los cambios circulares. Giros a la izquierda y a la derecha en discursos de asunción
Authors: Vincent Lucía
Published: January 2021

El objetivo de este artículo es comprobar que presidentes que llegan al poder con distinta orientación ideológica muestran una fuerte semejanza en el contenido de sus discursos de asunción. Estas similitudes se explican por la búsqueda de legitimación en el cargo, que los conduce a ubicarse en lo que, en cada momento histórico, se concibe como el centro político, con el objetivo de convencer a un amplio espectro de la ciudadanía. Esta hipótesis se comprueba para el caso de los discursos de asunción de tres presidentes argentinos: Néstor Kirchner (2003-2007), asociado con el giro a la izquierda en América Latina; Mauricio Macri (2015-2019), ubicado en el giro a la derecha, y Alberto Fernández (de 2019 en adelante), que vuelve a ubicarse hacia la izquierda. Este artículo abre la pregunta de si los giros políticos en América Latina, desde el punto de vista del momento inaugural, lejos de comportarse como un péndulo hacia un lado y el otro del espectro ideológico, constituyen, más bien, cambios circulares.
Monitoreo de residuos de plaguicidas en ajíes dulces en mercados selectos de San José de Ocoa y Santo Domingo, República Dominicana
Authors: Vallejo Degaudenzi Alejandro , Pérez Francelyn , Marranzini Camila , Tavárez Josefina
Published: January 2021

Los productos agrícolas dominicanos con fines de exportación se analizan constantemente en busca de residuos de plaguicidas. Algunos de estos agroalimentos presentan elevadas concentraciones de plaguicidas que sobrepasan los niveles máximos de residuos establecidos (LMR), convirtiéndose en una preocupación de seguridad alimentaria. El objetivo de este estudio fue identificar la presencia, tipos y concentraciones de 70 residuos de plaguicidas de uso común en el sector hortícola, en dos cultivares de ajíes, mediante la técnica de cromatografía de gases acoplada a espectrometría de masas (GC-MS), en mercados alimenticios seleccionados de la provincia San José de Ocoa y del Gran Santo Domingo. Desde enero del 2018 hasta junio del 2019, se recolectaron 117 muestras de ajíes dulces y estos fueron analizados utilizando la extracción de residuos múltiples QuEChERS, seguida de GC-MS. Se encontró que solo el 62 % cumplía con los LMR, siendo el clorfenapir y la cihalotrina los más frecuentemente detectados (27 y 19 muestras, respectivamente). También, se demostró la presencia de 19 variedades de plaguicidas, entre ellos dos organoclorados no permitidos: dicofol y diclorodifeniltricloroetano (DDT). Los altos niveles y la amplia variedad de residuos de pesticidas detectados en este proyecto sugieren la necesidad de promulgar regulaciones sobre el uso adecuado de pesticidas.