bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluasi Pelaksanaan Standar Mutu Kepelautan di Prodi Studi Nautika Politeknik Pelayaran Barombong
Authors: Rina Haryani  , Rachmat Tjahjanto  , Yudi Satria
Published: March 2024

Standar mutu Program studi Studi Nautika di Politeknik Pelayaran Barombong berpedoman pada standar mutu kepelautan Indonesia yang diatur dalam Surat Keputusan Direktur nomor. SK.8/III/POLTEKPEL.B-2021 tentang standar mutu kepelautan di lingkungan Politeknik Pelayaran Barombong, namun belum ada hasil evaluasi pelaksanaan standar mutu tersebut, sehingga perlu dievaluasi.    

      Evaluasi pelaksanaan ini menggunakan pendekatan kuantitatif. Hasil evaluasi menunjukkan bahwa semua standar penilaian yakni standar kompetensi lulusan, isi, proses, penbilaian, tenaga pendidik dan kependidikan, sarana dan prasarana, pengelolaan dan pembiayaan sudah sangat baik, namun demikian dari dari setiap unsur penilaian dalam setiap standar, masih ada yang belum terpenuhi dalam standar kompetensi lulusan, standar isi, standar proses, standar penilaian pendidikan, standar sarana dan prasarana, standar pengelolaan.
ANALISIS PREDIKSI KEBANGKRUTAN PERUSAHAAN DENGAN ALTMAN’S Z-SCORE MODIFIKASI DAN POLA ARUS KAS PADA PT. BUMI RESOURCES MINERALS TBK.
Authors: Riwoe Julians C. , - Winarto -
Published: March 2024

ABSTRACTOrganization sustainability depends on the management team in operating their company and how they formulate operating plan in manage their resources optimaly. Organization with fit management policy will compete the win and sustain in competition. This research aims to predict bankruptcy on PT. Bumi Resources Minerals Tbk. This Analysis uses the financial report data of PT. Bumi Resources Minerals Tbk. from the year 2010 – 2014 using the Altman’s Z-Score modificated and cash flow patterns. The Altman’s Z-Score using some ratio as: Working Capital to Total Assets, Retained Earnings to Total Assets, Earnings Before Interest and Taxes to Total Assets, and Market Value of Equity to Total Asset. This approach developt to find a bangkruptcy model namely Z-Score Modificated that is one of the strong model in predict organization bankrupcy level. The results of the analysis of Altman's Z-Score shows that in 2010 companies in the healthy zone, but there is a signal of financial trouble in the future because of the restrictions on the use of cash. In 2011 the company entered into the gray zone and then in 2012 to 2014 the company is in bankruptcy zones. Analysis Altman's Z-Score is strengthened by the cash flow pattern analysis showed that from 2010 to 2014, the net cash flow from operating activities continued deficit. Operating cash deficit resulted in the company failing to pay short-term debt, which is very minimal cash availability by 1% compared with short-term debt and stagnant operating activities for cash at the level fixed in 2013 and 2014. This indicator shows that the company is at the very financial difficulties or bankruptcy. Keywords: Bankruptcy, Altman’s Z-Score modificated, Cash flow patterns.
PENGARUH KEMUDAHAN DAN KEPERCAYAAN TERHADAP MINAT BELI PADA ONLINE SHOP (STUDI KASUS PADA ONLINE SHOP LAZADA)
Authors: Putri Angelia Cahya
Published: March 2024

ABSTRACTThe development of internet technology has increased the growth of e-commerce users and made e-commerce a promising business, so that many e-commerce players have sprung up. This makes the competition between e-commerce actors increasingly tight, and to attract consumer buying interest, e-commerce must provide convenience and trust to consumers. E-commerce is here to make it easier for consumers to shop so that consumers don't have to waste time and energy on getting the products they want, and in the online shopping process trust is needed, because consumers can't see products directly. One of the e-commerce companies in Indonesia is Lazada. The purpose of this study was to analyze the effect of convenience and trust on buying interest in the Lazada online shop. This study is a quantitative study with a sample of 210 respondents on consumers who have used Lazada at least 1 time and have a desire to buy products at Lazada. The analytical tool used is multiple regression analysis. This research has also been tested for validity and reliability so that it is continued with hypothesis testing with t test, F test and coefficient of determination (R2). Simultaneously, convenience and trust have an effect of 47.8% on buying interest and the remaining 52.2% is influenced by other factors not examined in this study. The results showed that there was a simultaneous and partial influence between convenience and trust on buying interest in Lazada.Keywords : Convenience, Trust, Buying Interest ABSTRAKBerkembangnya teknologi internet membuat semakin meningkatnya pertumbuhan pengguna e-commerce dan menjadikan e-commerce sebagai bisnis yang cukup menjanjikan, sehingga banyak pelaku-pelaku e-commerce yang bermunculan. Hal tersebut membuat persaingan antar pelaku e-commerce semakin ketat, dan untuk menarik minat beli konsumen maka sebuah e-commerce harus memberikan kemudahan dan kepercayaan kepada konsumen. E-commerce hadir untuk memudahkan konsumen dalam berbelanja sehingga konsumen tidak perlu membuang waktu dan tenaga dalam mendapatkan produk yang diinginkan, dan dalam proses belanja online diperlukan kepercayaan, karena konsumen tidak dapat melihat produk secara langsung. Salah satu e-commerce yang ada di Indonesia adalah Lazada. Tujuan dalam penelitian ini adalah untuk menganalisis pengaruh kemudahan dan kepercayaan terhadap minat beli pada online shop
FACTORS RELATED TO WORK STRESS IN THE ONLINE MOTORCYCLE TAXIS DRIVER COMMUNITY IN DEPOK CITY IN 2022
Authors: Shalsa Biella  , Noor Latifah  , Fini Fajrini
Published: March 2024

The incidence of stress is considered quite high, where more than 350 million people in the world experience stress. And according to the World Health Organization stress is a disease with the 4th rank in the world. It is recorded that around 10% of the population in Indonesia experience stress. Based on the results of previous research, it was found that in the coverage area of ​​Jakarta, Bogor, Depok, Tangerang, and Bekasi (Jabodetabek), there were 19 people (63.3%) online motorcycle taxi drivers who experienced stress, then online motorcycle taxi drivers who did not experience stress as many as 11 people. (36.7%). The purpose of this study was to find out the factors related to work stress in the online motorcycle taxi driver community in Depok City in 2022. The method in this study used a quantitative approach with a cross-sectional study design with a sample size of 130 respondents. The results of the bivariate analysis test showed that the variables related to work stress are age (p-value 0,000), gender (p-value 0,003), marital status (p-value 0,000), and workload (p-value 0,000). The variable that is not related to work stress is interpersonal relationships (p-value 0,236). This study concludes that the factors that have a relationship with work stress are age, gender, marital status, and workload. While the variables of interpersonal relationships have no relationship.
EFFECTIVENESS OF STUNTING PREVENTION PROGRAM AT BAJA HEALTH CENTER IN TANGERANG CITY
Authors: Suryani Tri
Published: March 2024

Stunting is a form of growth and developmental failure that causes linear growth disorders in toddlers due to the accumulation of nutritional deficiencies over a long period, starting from pregnancy to 24 months of age. The problem of malnutrition in Indonesia is a health issue that has not been fully addressed by the government. This can be seen from survey and research data such as the Basic Health Research (2018), which states that the prevalence of stunting (very short) in Indonesia is 19.3%, higher than in 2013 (19.2%) and 2007 (18%). Although many stunting prevention programs have been implemented by various parties and the health sector, these efforts have not effectively reduced the target number of stunting cases at the national level, posing a challenge for the health sector in preventing stunting cases. This research adopts a descriptive qualitative study design, where researchers aim to assess the effectiveness of the stunting prevention program in the working area of Baja Tangerang Health Center with three informants. Data collection techniques include interviewing related parties, observation, and documentation, with data analyzed by combining information from various existing sources. Health Center Baja has handled 2 children with malnutrition and 7 children with stunting. The results indicate that preventive measures must continue to be improved by meeting nutritional needs during pregnancy, monitoring child growth and development, and maintaining environmental hygiene. Integrated and multisectoral programs are needed to increase family income and prevent premature births (babies born not full term) to overcome the incidence of stunting in toddlers.
PREVENTION OF SEXUAL VIOLENCE THROUGH PUBERTY EDUCATION AT SDIT MUTIARA INSAN BEKASI REGENCY
Authors: Erry Utomo  , Nurfadhilah  , Dewi Purnamawati  , Dewi Andayani
Published: March 2024

Compared to a few decades ago, puberty now happens earlier, and the frequency of sexual assault is rising wildly. The purpose of this study is to examine how puberty education affects high-grade elementary school students' awareness of sexual assault prevention. With a facilitator in each class, the research design employs a quasi-experimental format of concurrent lectures and conversations lasting 60 minutes. 22 fourth-graders, 31 fifth-graders, and 31 sixth-graders make up the participants. Ten true-false questions from a pre-and post-test were used to gauge knowledge. The T-test was utilized in data analysis. The understanding of high school students significantly increased (P value 0.0001). All class discussions showed an exceptionally lively exchange of thoughts, and several students were particularly aggressive and engaged in raising issues of psychological (the recognition and control of emotions) and social (interpersonal connections and communication) interest. Continuous education is important, along with teaching strategies that are not the same as pedagogy or andragogy but rather suitable for the typical characteristics of adolescents.
Co-operative values and principles: A commentary.
Authors: Birchall Johnston
Published: March 2024

This paper reviews the co-operative values and principles in the light of values and principles adopted at the 1995 International Co-operative alliance centennial congress. It concludes that the next step for the ICA is to work out the implications for co-operative practice and that if understood in their richness of meaning, the values and principles should provide a firm foundation on which to start.
Structure, functioning, and role of co-operatives in the Nepalese economy
Authors: Shrestha Srijana , Chandra Dhakal Shiva
Published: March 2024

This short paper outlines research investigating the structure, operation, and role of co-operative groups in economic development in Nepal. Microsoft Excel and STATA 16 were used to examine the secondary data collected. In the fiscal year 2020/21, 125 co-operatives (0.42 per cent) are governed by the federal government, 6002 (20.08 per cent) by the provincial government, and 23,759 (79.50 per cent) by the local government. These co-operatives provide direct employment to 88,309 people. The province with the most co-operatives is Bagmati (10,418), where the Gross Domestic Product (GDP) growth rate is the highest (37.7 per cent), and the province with the least co-operatives is Karnali (1967), which has the lowest GDP growth rate (4 per cent). This suggests that the number of co‑operatives in a province influences GDP growth rate (per cent) in that province. The paper concludes by suggesting enabling the development of co-operatives at provincial level can be a significant means in uplifting the overall economic growth of the nation.
My friendship with Johnston Birchall
Authors: Akira Kurimoto
Published: March 2024

This short commemoration and appreciation of Johnston Birchall is from his friend and long-time associate, Professor Akira Kurimoto, Chair of ICA Committee on Co-operative Research (from 2021)
Journalist Attrition and its Expected Impact on Democracy in Bhutan
Authors: C Rinzin Yangchen
Published: March 2024

According to the human resources records of Kuensel, the number of journalists fell by 37 percent from 2021 to 2023, with only 4 out of 15 vacancies filled over the past two years. Other agencies are experiencing similar workforce challenges. While the departure of educators, civil servants, and health professionals has been featured in the headlines over the past year, little attention has been devoted to the attrition ongoing in the media itself. To understand the issues driving journalists out of the profession, a survey of a non-random sample was conducted of 63 professionals who worked as a journalist in the past five years. While 32 had left the profession, 31 stayed in the media. Of those who left the profession, 66 percent left in the past two years, and 44 percent left the country (for Australia in almost all cases). The rest remain in Bhutan but are no longer working as journalists. Of the leavers, 19 per cent are now unemployed, while the other 81 percent have moved on to new jobs, notably including teaching (in Bhutan) and aged care (in Australia). When asked about reasons for leaving the profession, low salary and lack of professional development came out as the most common complaints. Of the stayers, 40 percent expressed dissatisfaction with their pay, and 43 percent claimed to be actively searching for ways to change their employment status. This study reflects on the implications of the survey findings for the future of media and its relationship with democracy in Bhutan.
Pyrazole-directed, fluoroalcohol-free arylation of C-H bonds
Authors: Le Van Lam  , Nguyen Thanh Tung
Published: March 2024

Directed arylation of sp2 C−H bonds is often considered one of the most convenient methods to rapidly increase the complexity of organic molecules. However, most of the available methods utilized fluoroalcohols such as hexafluoroisopropanol (HFIP) as the solvent. Herein we report a simple method for palladium-catalyzed, directed arylation of arene C−H bond using acetic acid solvent. The successful functionalization relies on the use of pyrazole directing group.
PENYELESAIAN SENGKETA PEMILIHAN KEPALA DESA OLEH KEPALA DAERAH MENURUT UU NO 6 TAHUN 2014 TENTANG DESA
Authors: Lagalante Riswan , Mau Hedwig Adianto , Ismail Ismail
Published: March 2024

Undang-undang Nomor 6 Tahun 2014 tentang Desa memberikan kewenangan kepadakepala Daerah Bupati/Walikota dalam menyelesaikan sengketa hasil pemilihan kepala desa. Namun, undang-undang tersebut tidak mengatur secara rinci dan jelas mengenai mekanisme penyelesaian sengketa hasil pilkades. Adapun aturan turunanya seperti Peraturan Pemerintah Nomor 43 Tahun 2014 tentang Peraturan Pelaksana Undang-Undang Nomor 6 Tahun 2014 tentang Desa, Peraturan Menteri Dalam Negari Nomor 112 Tahun 2014 tentang Pemihan Kepala Desa Penelitian ini bertujuan untuk menguji dan menganalisis mekanisme penyelesaian sengketa hasil pilkades berdasarkan peraturan perundang-undangan Penelitian ini penulis gunakan metode penelitian Normatif, dengan metode pendekatan dengan menggunakan bahan hukum pustaka adengan kata lain, penelitian kepustakaan (Library Reaserch). Cara pengumpulan bahan hukum yang digunakan adalah studi dokumentasi yakni dengan mencatat informasi dari bahan hukum yang berkaitan dengan mekanisme penyelesaian sengketa berdasarkan peraturan perundang-undangan, maupun yang diperoleh dari sumber lain, baik pendapat ahli, hasil penelitian maupun jurnal. Dari hasil penilitian ini, bertujuan untuk menguji dan menganalisis mekanisme penyelesaian sengketa hasil pilkades berdasarkan peraturan perundang-undangan Indonesia dan konsep pembagian kekuasaan. menunjukan kewenangan kepala daerah Bupati/Walikota yang di berikan oleh Undang-undang. tidak seharusnya kenapa demikian karena bupati/walikota sebagai pejabat politik bukan sebagai hakim yang dapat memutuskan sengketa dalam hal ini pemilihan kepala desa. dinamika konfilk pilkades tidak terlepas dari kuasa secara politik dari pengaru rezim yang berkuasa (Bupati/Walikota). olehnya itu perlu adanya aturan yang lebih rinci lagi untuk mengatur mekanisme penyelesaian sengketa pilkades
Penerapan Dutch Angle Dalam Enggambarkan Emosional Pada Film “Tolong Aku”
Authors: Nazarruddin Nazarruddin  , Dani Manesah
Published: March 2024

Film, as a genre in the world of cinema, offers a short but captivating audiovisual experience. Films have the potential to create creative, entertaining works and have high artistic value. In the filmmaking process, various techniques and elements are used to improve the quality of the final result. Films are able to convey messages and emotions through various means, including dialogue, visuals, music and special effects. This research focuses on the important role of shooting techniques or cameras in film making. One of the techniques taught is Dutch Angle or Dutch Tilt, which involves tilting the camera angle on a vertical or horizontal axis. This technique is often used in the thriller and horror genres to create a dramatic effect on the audience. The film "Help Me" is an interesting case study, utilizing the Dutch Angle to produce emotions such as sadness, fear, anger, and surprise in the audience. The story of this film tells the story of a student named Dinda who is trapped in an organization that adheres to devil beliefs. Through the use of Dutch Angle, the audience is presented with an unstable atmosphere, creating tension and anxiety that blends with the main character's experiences. The aim of making the film "Help Me" is to apply the Dutch Angle technique to arouse the audience's emotions. In this way, the author hopes to strengthen the message and emotional nuances conveyed through this film. This research also aims to provide an overview of how shooting techniques in films can influence the audience's perception and emotions towards the work.
Analisis Transformasi Gender Pada Tokoh Utama Dalam Film Imperfect Sutradara Ernest Prakarsa.
Authors: Putri Aulia  , Dani Manesah  , Suryanto Suryanto
Published: March 2024

Gender transformation is an effort to achieve liberation from all forms of oppression, whether structural, personal, class, skin color or international economic. The transformation discussed by the author is gender transformation which is seen based on the appearance of the female main character in the imperfect film which is caused by the work environment, family, and so on, causing the female main character to undergo a gender transformation in appearance. This research aims to ensure that development benefits and resources are directed effectively and fairly to men and women. The method used by the author in this research is a quantitative method. Quantitative method is a research method that uses a lot of numbers. Starting from the data collection process to its interpretation. Meanwhile, the research method is an in-depth and careful study of all the facts.
Inovasi Pelayanan Publik Menggunakan Co Creation
Authors: Aida Alfita  , Banu Sulaeman Mubaraq  , Noerma Kurnia Fajarwati
Published: March 2024

Public service is a motivation for the public. The existence of a public service can be a control over arbitrariness in the hands of policy makers. Innovation in public services helps the government further upgrade the conditions of its territory. Law No. 25 of 2009 concerning Public Services is a breath of fresh air in efforts to provide good public services. This law mandates that public service is an activity or series of activities in order to fulfill service needs in accordance with statutory regulations for every citizen. Public service innovation cannot be separated from community participation. Public service innovation is also used in Bandung where co-creation methods are used to improve public services. This method is used by the Bandung Dukcapil Office. The application of co-creation is a new breakthrough in data openness and also the accuracy of data from the government
KEARIFAN LOKAL DALAM PEMANFAATAN TUMBUHAN UNTUK MENGATASI PENYAKIT DIABETES MELLITUS OLEH PENGOBAT TRADISIONAL DI KECAMATAN AMBALAU KABUPATEN BURU SELATAN
Authors: Pangemanan Victory O , Ukratalo Abdul M , Loilatu Muhammad Fitrah , Ichsan Muh. Nurhidayat , Pattimura Nadira , Manery Dodikrisno E
Published: March 2024

Introduction: Diabetes is a condition in which metabolism is disrupted. The large number of people who live in rural areas, especially in areas that are difficult to reach (isolated), makes it difficult to implement even distribution of development results such as education and health. Method: This research is a form of descriptive qualitative research with an exploratory observational design. Results: There are 6 types of plants used as diabetes mellitus medicine, namely sugar apple, horse grass, suruhan, lantana, antawali and castor oil. The plant parts used as medicine for diabetes mellitus are leaves, herbs and stems. Conclusion: Annona squamosa, Panicum maximum, Peperomia pellucida, Lantana camara, Tinospora crispa and Jatropha curcas L plants have potential as diabetes mellitus drugs.
LITERATURA NO ENSINO MÉDIO TÉCNICO: RESSIGNIFICANDO AS PRÁTICAS DE LEITURA E DE PRODUÇÃO TEXTUAL
Authors: Steinhorst Camila , Motta Vaima Regina Alves
Published: March 2024

Este artigo tem como objetivo relatar reflexões sobre a experiência como professora de Literatura durante a dinamização do projeto de Estágio Supervisionado em Letras, intitulado “Do conto ao romance: a experiência do mundo por meio da Literatura”, no Colégio Técnico Industrial de Santa Maria, em Santa Maria, Rio Grande do Sul. Ao longo deste texto, apresenta-se uma breve contextualização sobre os objetivos da disciplina de Literatura no Ensino Médio; sobre o conceito de Letramento Literário, desenvolvido por Cosson (2016) e sobre o projeto de estágio já referido. Em seguida, expõem-se reflexões acerca do empoderamento dos alunos com relação à leitura literária. Trata-se, portanto, de um trabalho que envolve pesquisa bibliográfica, de campo e analítico-qualitativa, e instrumentos como os questionários inicial e final. A priori, os resultados obtidos sugerem uma contribuição expressiva com as competências de leitura e de escrita da turma, que demonstrava ter pouca familiaridade com o exercício dessas habilidades no espaço da sala de aula.
Unpacking International Commitments: Assessing the Implementation of ICCPR, ICESCR, and the Convention Against Torture in Pakistan's Legal Framework
Authors: Baig Khurram , Tanveer Mahrukh , Rehman Ashna , Shahid Muhammad
Published: March 2024

Since time immemorial, the discourse surrounding human rights has occupied a central position in societal discussions. In the earliest epochs, these rights were not systematically codified, with the process evolving over centuries. A significant watershed moment occurred post-World War II, marked by the establishment of the United Nations and the consequential adoption of the Universal Declaration of Human Rights. Notwithstanding Pakistan's ratification of the majority of international Human Rights covenants, a comprehensive integration into its domestic legal framework remains elusive. This research article delves into an analysis of three pivotal Human Rights agreements, namely the International Covenant on Civil and Political Rights (ICCPR), the International Covenant on Economic, Social and Cultural Rights (ICESCR), and the Convention Against Torture. The study analyzes the extent of these treaties' assimilation within the domestic legal system, elucidating the complexities and impediments hindering complete incorporation. The ensuing discourse proffers substantive recommendations aimed at facilitating the seamless integration and efficacious implementation of these international accords, thereby fortifying the safeguarding of human rights on a national scale.
Luhatjet e fuqive të mëdha dhe qëndrimi Shqiptar pas kongresit të Lushnjës
Authors: Verli Marenglen
Published: March 2024

Periudha dhjetor 1919-janar 1920, ishte periudhë shumë e vështirë për Shqipërinë. Në Konferencën e Paqes në Paris, delegacioni shqiptar, pasi e kishin injoruar i kishin bërë të qartë se Shqipëria pavarësisht asnjanësisë gjatë Luftës së Parë Botërore, jo vetëm nuk do t’i rimerrte trevat copëtuara me vendimet e Konferencës së Londrës më 1913, po do të pësonte përsëri copëtime e kufizime në territorin dhe sovranitetin e vet. Traktati i Fshehtë i Londrës, i 26 prillit 1915, me anën e të cilit Fuqitë e Mëdha të Antantës, joshën Italinë të kalonte në anën e tyre në konfrontimin e madh botëror, e copëtonte shprehimisht Shqipërinë e 1913, në veri e në jug, në interes të Serbisë e Greqisë dhe në perëndim në interes të Italisë. Përveç qytetit dhe krahinës së Vlorës, që do të kalonin në sovranitetin italian, Roma siguronte edhe protektoratin mbi shtetin shqiptar të rrudhur midis luginave të Drinit dhe të Vjosës. Edhe pse me këmbënguljen e SHBA-së u duk sikur traktatet e fshehta nuk do të zbatoheshin, përsëri negociatat në Konferencë, preknin rëndë interesat e shqiptarëve dhe në bazën e tyre kishin përmbajtjen e Traktatit të 26 prillit.
Aktivitetet e Institutit të Historisë “Ali Hadri” - Prishtinë gjatë vitit 2017
Authors: Peli Teuta
Published: March 2024

Më 15 maj të vitit 2017, Instituti i Historisë “Ali Hadri” - Prishtinë organizoi Konferencën shkencore: “50 vjet të Institutit të Historisë “Ali

Hadri” - Prishtinë”. Fjalën e hapjes e mbajti prof. asoc. dr. Sabit Syla, drejtor i Institutit të Historisë “Ali Hadri”. Me fjalë rasti punimet e

Konferencës i përshëndetën: Hashim Thaçi - president i Republikës së Kosovës, akademik Arsim Bajrami - ministër i Arsimit, Shkencës dhe

Teknologjisë, Akademik Marenglen Verli - drejtor i Qendrës së Studimeve Albanologjike të Shqipërisë, mr. Lumi Hadri-Devine - vajza e Ali Hadrit, si dhe Enver Hoxhaj - ministër i Punëve të Jashtme.
Henry Gregory Huggins (1931–2022)
Authors: Davey Christopher J.
Published: March 2024

None.
Evolution of the MGMT gene in primates: from structure to mobile genetic elements
Authors: Pidpala O. V. , Lukash L. L.
Published: March 2024

The article collects data on the evolution of the reparative MGMT gene in primates and traces the evolutionary fate of a number of mobile genetic elements (MGEs). It was concluded that the evolution of the MGMT gene in primates underwent various changes from acquisition to loss of exon/intron sequences. As for primate-specific MGEs, they have a different evolutionary history and path - from the formation of species/genus-specific sequences to deletional degradation and can be components not only of intronic or exonic sequences, but also components of exons in the form of fragmented sequences and not be identified as MGEs.
Pott’s puffy tumor of the upper eyelid misdiagnosed as simple abscess: a case report and literature review
Authors: Kim Kuylhee , Lee Donghyun , Jung Soyeon , Chung Chul Hoon , Chang Yongjoon
Published: March 2024

A 76-year-old woman, initially thought to have a simple abscess on her right upper eyelid, presented to our department of plastic and reconstructive surgery. Enhanced three-dimensional facial computed tomography (CT) revealed an abscess on the right upper lid, with a pyomucocele present in the right frontal sinus, accompanied by bone erosion in the superior wall of the right orbit. Based on the results of the CT scan, we diagnosed an atypical Pott’s puffy tumor (PPT) with an abscess on the upper lid originating from the frontal sinusitis. First, surgical incision and drainage were performed in our department, and a percutaneous vacuum drain was placed. To provide a more definitive treatment, endoscopic sinus surgery (ESS) was subsequently performed by otorhinolaryngologists. The patient was discharged without any complications 5 days after ESS. At a 1-year follow-up, no recurrence or notable neurological symptoms were observed. In the case we observed, the patient presented with an upper eyelid abscess and cellulitis, indicating possible orbital involvement. For such patients, a CT scan is necessary. Given the possibility of PPT, it is critical to perform a comprehensive differential diagnosis rather than defaulting to a straightforward approach involving abscess treatment.
Intraosseous vascular malformation of the skull: a case report and literature review
Authors: Lee Donghyun , Chung Chul Hoon , Cho Seong Jin
Published: March 2024

A 59-year-old woman presented to our clinic with a 3.5× 3-cm protruding mass on her forehead. A skull X-ray revealed a radiolucent osteolytic lesion on the left side of the frontal bone. Additionally, computed tomography showed a 3.1× 1.7× 3.6-cm mass exhibiting a “sunburst” pattern situated between the outer and inner tables of the skull, just superior and lateral to the left frontal sinus. This pattern suggested the presence of an intraosseous vascular malformation (IVM). The lesion was approached via a bicoronal incision. En-bloc resection was performed, removing the mass along with approximately 0.5 cm of the surrounding normal bone without injury to the exposed frontal sinus mucosa. The exposed mucosa was reinforced with a galeal flap, and cranioplasty with bone cement was performed to repair the resulting bony defect. Pathological examination confirmed a diagnosis of intraosseous cavernous-type malformation with mixed cavernous and capillary histological features. We report this case of IVM and review the existing literature, highlighting the satisfactory functional and aesthetic outcomes after surgery.
Des espaces communs de citoyenneté culturelle ?
Authors: Derbas Thibodeau François R. , Poirier Christian
Published: March 2024

Cet article s’intéresse aux visions et aux pratiques collaboratives entre institutions culturelles et organismes communautaires, thématique encore peu traitée de façon empirique et dans la littérature scientifique. Le domaine des bibliothèques publiques au Québec apparaît comme un cas particulièrement pertinent, proposant avec le modèle du « tiers-lieu » une redéfinition des approches traditionnelles de relation aux publics, ainsi qu’un virage « citoyen » s’arrimant notamment au déploiement d’espaces de collaboration diversifiés, incluant des acteurs de la société civile organisée particulièrement interpellés par ces évolutions. Comment les dimensions citoyennes et les représentations symboliques de la collaboration sont-elles travaillées par une pluralité d’acteurs aux intérêts, aux représentations et aux modes d’action différenciés ? Quelles synergies et conflictualités les structurent ou en découlent? Mobilisant le concept de citoyenneté culturelle, l’article s’appuie sur une démarche qualitative comportant des entretiens de groupe auprès de responsables d’organismes consacrés aux femmes monoparentales et aux jeunes ainsi qu’une recherche documentaire. Il permet de mettre au jour un écart entre les intentions et les logiques institutionnelles effectives, qui témoigne du caractère toujours embryonnaire de l’instauration d’espaces communs de citoyenneté culturelle. L’étude développe des considérations théoriques et empiriques qui en découlent, proposant une réflexion portant sur une conception « forte » de la démocratie culturelle et soulignant la pertinence du politique, tant pour la recherche que pour les milieux de pratique.
Intervention artistique et production de citoyenneté dans un quartier de Santiago du Chili
Authors: Ossandón Fernando , Campos Medina Luis , Aubán Borrel Mónica
Published: March 2024

Le Musée à ciel ouvert de San Miguel est une initiative lancée en 2010 par des habitant·e·s du quartier du même nom, dans le but de contrer la détérioration de l’environnement ainsi que la pression des entreprises immobilières. Dans le présent texte, nous nous intéressons à la création et au développement de ce musée dans une optique de production de citoyenneté. Nous proposons d’envisager ce phénomène comme un cas d’« extension du processus d’inclusion » (Sassen, 2003 : 64) qui interviendrait dans les dynamiques matérielles et symboliques de l’inégalité urbaine au Chili. Cette inclusion expansive favoriserait la revitalisation des relations au sein de la population. La méthodologie consiste en la réalisation de trente-cinq entretiens individuels, six entretiens de groupe, trois accompagnements à des visites guidées d’étudiant·e·s ainsi qu’en une cartographie des investissements et une cartographie des oeuvres murales du quartier. En nous appuyant sur les informations tirées de cette recherche, nous concluons que le Musée à ciel ouvert de San Miguel correspond à une nouvelle manière de composer le territoire du quartier, dans la mesure où ce musée a permis l’émergence de nouveaux modes d’interaction chez ses habitant·e·s, de nouvelles dynamiques de relation à l’égard du milieu dans lequel il se trouve ainsi que de nouvelles formes de reconnaissance qui dérogent aux stigmates habituels associés aux quartiers pauvres de Santiago de Chile.
Trimetazidine attenuates neuroinflammation via TLR4/NF-KB pathway inhibition in lipopolysaccharides-induced dementia in rats
Authors: Mahmoud Nadia S. , Elbaset Marawan A. , Mohawed Ola A.M. , Ahmed Hanaa H.
Published: March 2024

Neurodegenerative dementia impairs mental ability and short-term memory. This study investigated the effectiveness of trimetazidine (TMZ) in mitigating lipopolysaccharides-induced dementia in rats. Fifty male rats were randomly assigned into five groups; normal control, dementia, whereas other groups represented as dementia groups administered with 20, 40 mg/kg of TMZ, and 10 mg/kg of memantine, successively. Behavioral testing demonstrated a cognitive decline in dementia rats. Moreover, treatment with TMZ or memantine revealed a substantial decline in serum tau and phosphorylated tau with concurrent amelioration of serum Amyloid beta 1-42, neurogranin, 3-methoxy4-hydroxyphenyl glycol, APL1b25, APL1b27, and APL1b28 levels. Furthermore, such treatments yielded a significant down-expression of hippocampal toll-like receptor 4, NF-kB, cyclooxygenase-2, tumor necrosis factor-α, inducible nitric oxide synthase, caspase-3, and over-expression of Bcl-2 gene along with remarkable improvement in the hippocampal histoarchitecture as well as in the ionized calcium-binding adapter molecule 1 immunostaining compared the derangement in the dementia group. This study sheds light on TMZs neuroprotective effect on dementia pathophysiology by counteracting neuroinflammation. In conclusion, this study underscores the potential of TMZ in attenuating lipopolysaccharide-induced dementia in rats, offering significant cognitive and molecular benefits. The observed improvements in cognitive performance, serum markers, and hippocampal gene expression patterns collectively highlight TMZs neuroprotective capacity, suggesting its viability as a promising therapeutic intervention for addressing neurodegenerative dementia.
Predictive bioactivity of compounds from Vitis gracilis leaf extract to counteract doxorubicin-induced cardiotoxicity via sirtuin 1 and adenosine monophosphate-activated protein kinase: An in-silico study
Authors: Santoso Putra , Ilyas Syafruddin , Midoen Yurnadi Hanafi , Maliza Rita , Belahusna Dinda Fadhillah
Published: March 2024

Doxorubicin is a potent chemotherapy drug. However, it is known to cause cardiotoxicity via inhibition of sirtuin 1 (SIRT1) and adenosine monophosphate protein kinase (AMPK) activity in the cardiomyocytes. This research aimed to explore the pharmacokinetics, safety, and bioactivity of compounds from Vitis gracilis leaves in their interaction with SIRT1 and AMPK to counteract doxorubicin-induced cardiotoxicity. A total of 13 selected compounds from V. gracilis leaf extract were screened for their pharmacokinetics, toxicity, and interactions with SIRT1 and AMPK using in silico approach. It was found that the majority of the compounds are easily absorbed by the human intestine, mostly avoiding liver enzyme CYP2D6 interaction and kidney protein OCT2 inhibition. They span nontoxic to harmful, some posing hepatoxic, carcinogenic, and immunotoxic risks, while 12 meet drug-likeness criteria. Finally, molecular docking revealed that several compounds exhibit high binding affinities to the proteins SIRT1 and AMPK, with some even outperforming the standard drug resveratrol such as 3’,4’-dimethoxy-alpha-naphthoflavone, 5-[6-hydroxy-5-(3-methylbut-2-enyl)-1-benzofuran-2-yl]benzene-1,3-diol, 4,4-dimethyl-5alpha-cholesta-8,14,24- trien-3beta-ol, and norethindrone acetate. Therefore, the compounds could be considered candidates of drugs to counteract doxorubicin-induced cardiotoxicity via SIRT1 and AMPK activation.
Primera cita del murciélago de Nathusius Pipistrellus nathusii (Keyserling & Blasius, 1839) para las Islas Baleares
Authors: Trujillo Domingo , García David
Published: March 2024

We have conducted a bat diversity study in La Albufera Natural Park (Majorca Island). We have verified the presence of a total of eleven different bat species within the protected area. In the framework of this study we have detected for the first time the presence of the Nathusius’ Pipistrelle (Pipistrellus nathusii), being the first record for the species in Majorca Island and the Balearic Archipelago. A single female of this species was measured, wing-punched and photographs of upper teeth were taken before releasing it to back up its taxonomic identification. This finding rises up to nineteen the number of bat species founded in the Balearic Archipelago and evidences the need to pay more attention and investment to this kind of work in order to achieve a complete estimate of the biodiversity of this group of mammals and promote realistic measures to guarantee its conservation.
Exploring factors shaping antibiotic resistance patterns in Streptococcus pneumoniae during the 2020 COVID-19 pandemic
Authors: Kovacevic Aleksandra , Smith David RM , Rahbé Eve , Novelli Sophie , Henriot Paul , Varon Emmanuelle , Cohen Robert , Levy Corinne , Temime Laura , Opatowski Lulla
Published: March 2024

Non-pharmaceutical interventions implemented to block SARS-CoV-2 transmission in early 2020 led to global reductions in the incidence of invasive pneumococcal disease (IPD). By contrast, most European countries reported an increase in antibiotic resistance among invasive Streptococcus pneumoniae isolates from 2019 to 2020, while an increasing number of studies reported stable pneumococcal carriage prevalence over the same period. To disentangle the impacts of the COVID-19 pandemic on pneumococcal epidemiology in the community setting, we propose a mathematical model formalizing simultaneous transmission of SARS-CoV-2 and antibiotic-sensitive and -resistant strains of S. pneumoniae. To test hypotheses underlying these trends five mechanisms were built into the model and examined: (1) a population-wide reduction of antibiotic prescriptions in the community, (2) lockdown effect on pneumococcal transmission, (3) a reduced risk of developing an IPD due to the absence of common respiratory viruses, (4) community azithromycin use in COVID-19 infected individuals, (5) and a longer carriage duration of antibiotic-resistant pneumococcal strains. Among 31 possible pandemic scenarios involving mechanisms individually or in combination, model simulations surprisingly identified only two scenarios that reproduced the reported trends in the general population. They included factors (1), (3), and (4). These scenarios replicated a nearly 50% reduction in annual IPD, and an increase in antibiotic resistance from 20% to 22%, all while maintaining a relatively stable pneumococcal carriage. Exploring further, higher SARS-CoV-2 R0 values and synergistic within-host virus-bacteria interaction mechanisms could have additionally contributed to the observed antibiotic resistance increase. Our work demonstrates the utility of the mathematical modeling approach in unraveling the complex effects of the COVID-19 pandemic responses on AMR dynamics.
Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher Advanced Glycation End-products (AGEs) content and reduced bone strength
Authors: Leanza Giulia , Cannata Francesca , Faraj Malak , Pedone Claudio , Viola Viola , Tramontana Flavia , Pellegrini Niccolò , Vadalà Gianluca , Piccoli Alessandra , Strollo Rocky , Zalfa Francesca , Beeve Alec , Scheller Erica L , Tang Simon , Civitelli Roberto , Maccarrone Mauro , Papalia Rocco , Napoli Nicola
Published: March 2024

Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that bone formation genes (
SOST
and
RUNX2
) and Advanced Glycation End-products (AGEs) were impaired in T2D. We investigated Wnt signaling regulation and its association with AGEs accumulation and bone strength in T2D from bone tissue of 15 T2D and 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend of low mineralized volume in T2D [(T2D 0.249% (0.156-0.366) vs non-diabetic subjects 0.352% (0.269-0.454); p=0.053)], as well as reduced bone strength [T2D 21.60 MPa (13.46-30.10) vs non-diabetic subjects 76.24 MPa (26.81-132.9); p=0.002]. We also showed that gene expression of Wnt agonists
LEF-1
(p=0.0136) and
WNT10B
(p=0.0302) were lower in T2D. Conversely, gene expression of
WNT5A
(p=0.0232),
SOST
(p<0.0001) and
GSK3B
(p=0.0456) were higher, while collagen (
COL1A1
) was lower in T2D (p=0.0482). AGEs content was associated with
SOST
and
WNT5A
(r=0.9231, p<0.0001; r=0.6751, p=0.0322), but inversely correlated with
LEF-1
and
COL1A1
(r= -0,7500, p=0.0255; r= -0,9762, p=0.0004).
SOST
was associated with glycemic control and disease duration (r=0.4846, p=0.0043; r=0.7107, p=0.00174), whereas
WNT5A
and
GSK3B
were only correlated with glycemic control (r=0.5589, p=0.0037; r=0.4901, p=0.0051). Finally, Young’s Modulus was negatively correlated with
SOST
(r=-0.5675, p=0.0011),
AXIN2
(r=-0.5523, p=0.0042) and
SFRP5
(r=-0.4442, p=0.0437), while positively correlated with
LEF -1
(r=0.4116, p=0.0295) and
WNT10B
(r=0.6697, p=0.0001). These findings suggest that Wnt signaling, and AGEs could be the main determinants of bone fragility in T2D.
TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis
Authors: Chotiner Jessica Y. , Leu N. Adrian , Yang Fang , Cossu Isabella G. , Guan Yongjuan , Lin Huijuan , Wang P. Jeremy
Published: March 2024

Meiotic progression requires coordinated assembly and disassembly of protein complexes involved in chromosome synapsis and meiotic recombination. The AAA+ ATPase TRIP13 and its orthologue Pch2 are instrumental in remodeling HORMA domain proteins. Meiosis-specific HORMAD proteins are associated with unsynapsed chromosome axes but depleted from the synaptonemal complex (SC) of synapsed chromosome homologues. Here we report that TRIP13 localizes to the synapsed SC in early pachytene spermatocytes and to telomeres throughout meiotic prophase I. Loss of TRIP13 leads to meiotic arrest and thus sterility in both sexes.
Trip13
-null meiocytes exhibit abnormal persistence of HORMAD1 and HOMRAD2 on synapsed SC and chromosome asynapsis that preferentially affects XY and centromeric ends. These findings confirm the previously reported phenotypes of the
Trip13
hypomorph alleles.
Trip13
heterozygous (
Trip13
+/-
) mice also exhibit meiotic defects that are less severe than the
Trip13
-null mice, showing that TRIP13 is a dosage-sensitive regulator of meiosis. Localization of TRIP13 to the synapsed SC is independent of SC axial element proteins such as REC8 and SYCP2/SYCP3. The N- or C-terminal FLAG-tagged TRIP13 proteins are functional and recapitulate the localization of native TRIP13 to SC and telomeres in knockin mice. Therefore, the evolutionarily conserved localization of TRIP13/Pch2 to the synapsed chromosomes provides an explanation for dissociation of HORMA domain proteins upon chromosome synapsis in diverse organisms.
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel
Authors: Ahrends Christine , Woolrich Mark W , Vidaurre Diego
Published: March 2024

Predicting an individual’s cognitive traits or clinical condition using brain signals is a central goal in modern neuroscience. This is commonly done using either structural aspects, such as structural connectivity or cortical thickness, or aggregated measures of brain activity that average over time. But these approaches are missing a central aspect of brain function: the unique ways in which an individual’s brain activity unfolds over time. One reason why these dynamic patterns are not usually considered is that they have to be described by complex, high-dimensional models; and it is unclear how best to use these models for prediction. We here propose an approach that describes dynamic functional connectivity and amplitude patterns using a Hidden Markov model (HMM) and combines it with the Fisher kernel, which can be used to predict individual traits. The Fisher kernel is constructed from the HMM in a mathematically principled manner, thereby preserving the structure of the underlying model. We show here, in fMRI data, that the HMM-Fisher kernel approach is accurate and reliable. We compare the Fisher kernel to other prediction methods, both time-varying and time-averaged functional connectivity-based models. Our approach leverages information about an individual’s time-varying amplitude and functional connectivity for prediction and has broad applications in cognitive neuroscience and personalised medicine.
Effect of Influenza Vaccination in Patients with Cardiovascular Disease: An Updated Meta-Analysis of Randomized Controlled Trials
Authors: Burgos Lucrecia María , Zaidel Ezequiel J. , Sosa Lipradi Álvaro , Baranchuk Adrián
Published: March 2024

Background: Influenza is a major cause of morbidity and mortality in patients with cardiovascular disease (CVD). The aim of this updated systematic review and meta-analysis was to evaluate the effect of influenza vaccination (IV) on morbidity and morbidity in adult patients with CVD. Methods: We conducted a systematic review and meta-analysis (PubMed, Cochrane Library, International Clinical Trials Registry Platform, and manual search of conference presentations) of randomized clinical trials published up to April 2022 analyzing whether IV reduced all-cause mortality in adult patients with CVD, including heart failure (HF) and coronary artery disease (CAD), compared with patients who were not vaccinated. Results: A total of six clinical trials comprising 9316 patients were analyzed. Five trials included CAD patients, and one trial included HF patients. Mean follow-up was 16 ± 9.7 months. Influenza vaccine was associated with a reduction of mortality compared to controls: relative risk (RR) 0.67, 95% confidence interval (95% CI), 0.47-0.95; p = 0.03; I2 = 53%, and with reduction of cardiovascular death compared to controls: RR 0.64; 95% CI 0.44-0.94; p = 0.02; I2 = 54%. There was a non-statistically significant reduction in myocardial infarction compared to control: RR 0.82, 95% CI 0.60-1.12; p = 0.57; I2 = 0%. Conclusion: In this meta-analysis of six randomized controlled clinical trials, IV was associated with a 33% and 36% relative risk reduction of all-cause mortality and cardiovascular death, respectively, in patients with CVD. We sought to promote consensus about the persistent benefits of influenza vaccination in patients with CVD by including two new clinical trials in CAD and HF, confirming the association of vaccination with risk reduction in subjects with CVD.
Developing a Faith-Based Virtual Psychoeducation Program to Enhance Addiction Services for Canadian Muslims: C-MAP
Authors: Ahmed Fardowsa , Ragheb Heba , Isgandarova Nazila , Khokhar Jibran , Azab Marwa , Ali Allie , Twakkal Abd Alfatah , Hassan Ahmed N.
Published: March 2024

Canadian Muslims are a growing population at an increased risk of addiction who have been found to underutilize health services. The Canadian-Muslim Addiction Program (C-MAP) offers an innovative intervention serving as a practice for public-health education to transform addiction care in this population by reducing stigma and increasing help-seeking.