bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemphigus foliaceus with Anti-Intercellular and Anti-Basement Membrane Zone Antibodies
Authors: Muramatsu Tsutomu , Shirai Toshihiko , Sakamoto Kuniki , Ikeda Shigaku , Ogawa Hideoki
Published: October 2009

In a patient with clinical, histologic, and routine direct immunofluorescence (IF) findings compatible with pemphigus foliaceus (PF), anti-intercellular and anti-basement membrane zone (BMZ) antibodies were found on indirect IF. Blocking IF studies using the biotin-avidin method revealed that intercellular staining of this patient’s serum was significantly decreased by sera of PF patients, however, reaction of this patient’s serum was not blocked by sera of PV and BP patients. Western immunoblot analysis using the SDS extracts of normal human epidermis demonstrated that this patient’s serum reacted with 370-, 220-, 170-, 130- and 21-kD proteins. Another PF serum reacted with 170- and 21-kD proteins. BP sera reacted with 220-, 68-, 46 and 21-kD proteins. Considering the results of the previous reports and this study, 220- and 170-kD protein bands are specific for BP and PF, respectively, and this is the first case of PF with both anti-intercellular and anti-BMZ circulating antibodies including immunoblotting analysis.
Papular Xanthoma
Authors: Bundino Silvana , Zina Alberto Maria , Aloi Filippo
Published: October 2009

The 5th case of papular xanthoma is reported. This entity can be differentiated on the basis of clinical and histological features: normolipidemic, nonconfluent, eruptive xanthomas located on the face, trunk and mucous membranes with no internal involvement. Histologically there are foamy cells and Touton giant cells without an inflammatory or histiocytic component. Electron microscopy shows macrophages packed with free lipidic vacuoles and lacking specific markers.
Reiter’s Syndrome and Human Immunodeficiency Virus Infection
Authors: Lin Robert Y.
Published: October 2009

A 35-year-old Black male with a long history of intravenous drug abuse developed clinical manifestations of Reiter’s syndrome, with significant joint and psoriasiform skin involvement. In addition, he had signs and symptoms compatible with human immunodeficiency virus (HIV) infection and had a positive HIV antibody test confirmed with Western blot testing. Although many dermatologic manifestations of HIV infection have been described, this is the first time that an association with Reiter’s syndrome has been reported. Recently, the development of psoriasis in other patients with HIV infection has been described. Taken together, these occurrences suggest that the purported retroviral relationship with psoriasis and related dermatoses may warrant further examination.
Dominant Dystrophic Epidermolysis bullosa of Cockayne-Touraine in Father and Son: Clinical and Ultrastructural Similarities
Authors: De Raeve L. , De Dobbeleer G. , Song M. , Achten G.
Published: October 2009

Dominant dystrophic epidermolysis bullosa of Cockayne-Touraine occurred in a father and his son. Clinically, the child presented evident blistering, while the father, despite of his work, where minimal skin traumata frequently occur, was rarely affected. Absent or rudimentary anchoring fibrils were seen in the normal-appearing skin of the father; this suggests that other factors may play a role in the dermolytic separation.
Nevocytic Nevi and Skin Complexion
Authors: Rampen F.H.J.
Published: October 2009

There exists a large body of evidence that the occurrence of nevocytic nevi is closely related to skin complexion. Nevi are more frequent in Caucasians with a light skin than in those with a dark phenotype. In Orientals and Negroids nevocytic nevi are uncommon. Within a black population subjects with a relatively light complexion have greater total counts than those with a very dark skin. It is concluded that literature data dealing with mole proneness in relation to skin complexion strongly point to an association of high nevus counts with light complexion. This applies to differences between racial groups as well as to differences between complexion phenotypes within a given racial group.
Tinea faciei Caused by Microsporum canis in a Newborn
Authors: Hiruma Masataro , Kukita Atsushi
Published: October 2009

A case of tinea faciei caused by Microsporum canis in a 14-day-old infant is reported. The incubation period was seen to be 1 week. This was a familial infection which also affected the infant’s grandmother and their pet cat and dog. Topical treatment with clotrimazole controlled the infection in the baby. A review of 14 cases (including our own) of dermatophytosis in newborn infants reported in the Japanese literature showed that newborn infants might be infected by several of these agents.
Herpes gestationis in Mother and Erythemato-Pustulous Rash in the Newborn with Positive Direct Immunofluorescence
Authors: Guillet G. , Nougue J. , Oksman F.
Published: October 2009

A 24-year-old secundigravida presented at 38 weeks of amenorrhea with typical cutaneous lesions of herpes gestationis. The newborn developed a skin rash 3 days after birth. The rash clinically resembled erythema toxicum neonatorum with dermal infiltrate of lymphocytes and eosinophilic polymorphonuclear cells forming a few intraepidermal pustules. The complement-binding antibody test for herpes gestationis factor was negative, but direct immunofluorescence study on this biopsy demonstrated a linear deposit of IgG and complement on the basement membrane zone. The possible transmission of the disease to the newborn is discussed.
Is Etretinate Dangerous in Papillon-Lefèvre Syndrome?
Authors: Tosti Antonella , Manuzzi Patrizia , Bardazzi Federico , Costa Angela
Published: October 2009

A 23-year-old girl affected by Papillon-Lefèvre syndrome developed, during Etretinate therapy (1 mg/kg/day), two liver abscesses caused by pyogenic bacteria and a subphrenic abscess. The immunological effects of retinoids may precipitate severe infections in patients with Papillon-Lefèvre syndrome, who probably have a basic, even though not always evident, defect of PMN chemotaxis.
Presence of Two Strains of Neisseria gonorrhoeae in Both the Cervix and Pharynx of a Patient with Disseminated Infection Caused by a Single Strain
Authors: Korting H.C. , Abeck D. , Johnson A.P.
Published: October 2009

Neisseria gonorrhoeae was cultured from the cervix, pharynx and blood stream of an 18-year-old woman who had a disseminated gonococcal infection. Two different phenotypes of N.gonorrhoeae, distinguished on the basis of their protein 1 serovar, whole-cell protein profile, lectin-type and antibiotic susceptibility, were isolated from both the cervix and pharynx, whereas only one of these phenotypes was isolated from the blood. This finding stresses the importance of blood cultures as a prelude to determining appropriate antimicrobial therapy in cases of disseminated gonococcal infection.
Intraepidermal Accumulation of Polymorphonuclear Leukocytes in Annular Pustular Psoriasis
Authors: van de Kerkhof P.C.M. , Lammers A.M.
Published: October 2009

A case of annular pustular psoriasis is described. The annular zone of the lesion provides a model for studying the dynamics of intraepidermal accumulation of polymorphonuclear leukocytes in psoriasis. It could be shown that the unstimulated accumulation of polymorphonuclear leukocytes was limited to the clinically involved skin. The appearance of polymorphonuclear leukocytes proved to be associated with acanthosis. The micropustule formation following topical application of leukotriene B4 was markedly decreased in lesional, prelesional and postlesional skin, compared to the response in the clinically uninvolved skin of patients with chronic plaque psoriasis. Although leukotriene B4 might have an initiating role in the intraepidermal accumulation of polymorphonuclear leukocytes other factors are a conditio sine qua non for the peripheral spreading of the lesion in annular pustular psoriasis.
Titanium Balanitis with Phimosis
Authors: Dundas S.A.C. , Laing R.W.
Published: October 2009

We report the 2nd case of titanium balanitis reported in the world literature. Clinically the patient presented with phimosis: histologically the titanium was surrounded by a mixed granulomatous inflammatory reaction. Topical titanium preparations may lead to phimosis and therefore we thought it important to bring this potential iatrogenic complication to further notice.
Dithranol: Further Investigations on the Structure-Activity-Relationship
Authors: Schaltegger A. , Brunner F. , Steiger W. , Krebs A.
Published: October 2009

The in vitro stability of 10-ethyldithranol (1,8-dihydroxy-10-ethyl-9(10H)-anthracenone) and its effects on healthy and psoriatic skin is investigated. 10-Ethyldithranol as a representative of the new class of 10-alkyldithranol derivatives neither stains nor irritates and has no antipsoriatic activity at all. This is due to the relatively stable substituent at carbon 10 which enables the fast oxidation processes necessary for the antipsoriatic effect. Therefore, antipsoriatically active dithranol derivatives require a free or easily liberated 10-position and hence the so-called ‘minimum structure of antipsoriatic anthrones’ keeps its validity.
Angioproliferative Changes in Clinically Noninvolved, Perilesional Skin in AIDS-Associated Kaposi’s Sarcoma
Authors: Ruszczak Zbigniew , da Silva Augusto Mayer , Orfanos Constantin E.
Published: October 2009

In clinically noninvolved skin from the area surrounding early macular lesions of AIDS-associated disseminated Kaposi’s sarcoma (KS), morphological evidence of vascular proliferation was seen in the upper papillary dermis. Poorly differentiated cells with cytoplasmic inclusions similar to Weibel-Palade bodies were found to form primitive vascular lumina. Around the vessels, dermal Langerhans’ cells and lymphoid cells were detected. Spindle-shaped cell proliferation characteristic of fully developed KS lesions was not observed. The angioproliferative changes, undetectable clinically, were similar, though less evident, to those observed in early lesions of disseminated KS, but without stroma tissue reaction. These findings suggest that in AIDS-associated KS angioproliferation may not be restricted to the clinically detectable lesions and that some angioplastic factor(s) may cause widespread endothelial hyperproliferation.
Rate and Topography of Follicular Sebum Excretion
Authors: Piérard G.E.
Published: October 2009

We have designed a combined method using a lipid-absorbent tape and skin surface stripping to evaluate the relationship between the follicular sebum excretion rate and the microanatomy of the follicular duct openings. Many sebaceous follicles appear quiescent in normals and with acne patients. Most of the large spots on the lipid-absorbent tape are due to the confluence of smaller ones. ‘Open’ comedones in acne are functionally closed.
Additional Effect of Grenz Rays on Psoriasis Lesions of the Scalp Treated with Topical Corticosteroids
Authors: Johannesson Anders , Lindelöf Bernt
Published: October 2009

In a double-blind study comprising 17 patients with symmetrical psoriasis lesions of the scalp, the combination of grenz ray treatment and topical steroid showed a faster clearing than with the topical steroid alone. The results also indicate a longer remission time with the combination therapy compared to grenz rays alone. Therefore both the faster clearing and the longer remission time with the combination therapy, as compared to our previous study of grenz ray treatment of scalp psoriasis, are probably due to the additional effect of steroid therapy, on grenz rays.
Retinoids and Keratinocyte Differentiation in vitro
Authors: Stadler R. , Müller R. , Detmar M. , Orfanos C.E.
Published: October 2009

Standard retinoids (e.g. etretinate, isotretinoin) are successful in the treatment of a variety of dermatological disorders. However, they are handicapped by an unfavorable ratio between activity and toxicity. In order to find more successful substances new promising compounds were recently synthesized. The aim of this study was to screen new monoaro-mates (etretin (Ro 10–1670) , demethyletretin (Ro 12–7310), 13-cis-etretin(Ro 13–7652) and the polyaromates arotinoid (Ro 15–0778), arotinoid acid (Ro 13–7410) and arotinoid ethyl sulfone (Ro 15–1570) for their effect on keratinocyte differentiation in vitro and to compare these results with differentiation data of retinoids currently used clinically. It was found that the second generation of retinoids had a lower antikeratinizing potential than the third generation of retinoids. They markedly inhibited crosslinked keratins and envelope proteins. Arotinoid acid was found to be the most potent derivative. In contrast to this, differences with regard to the synthesis of keratohyalingranule macroaggregates were detected between the retinoid derivatives. Arotinoid acid and arotinoid sulfone stimulated this protein fraction, whereas arotinoid left this fraction uninfluenced. If the data obtained were considered the selection criterion for the future therapeutic application of the new arotinoids in psoriasis therapy, it should be more useful to employ arotinoid acid or arotinoid sulfone rather than arotinoid in clinical psoriasis studies.
Retinoids in Disorders of Keratinization: Their Use in Adults
Authors: Happle R. , van de Kerkhof P.C.M. , Traupe H.
Published: October 2009

Hereditary disorders of keratinization may be a considerable handicap. Oral treatment with retinoids has been shown to be effective in many of these diseases. In the group of ichthyoses, the best results can be obtained in the various types of nonbullous congenital ichthyosis (erythrodermic autosomal recessive lamellar ichthyosis, nonerythrodermic autosomal recessive lamellar ichthyosis, autosomal dominant lamellar ichthyosis). It should be borne in mind, however, that retinoid therapy alone cannot lead to a complete response of these forms of ichthyosis and that this treatment cannot replace an appropriate topical treatment. During continuous treatment with etretinate a reduction of the dosis to 0.5 mg/kg is often necessary. Etretinate treatment of bullous congenital ichthyosiform erythroderma is more difficult, and it is advisable to begin with a low dosis of 0.25–0.5 mg/kg. The epidermolytic form of palmoplantar keratoderma is in our opinion no indication for retinoid treatment which seems to result inevitably in large erosions. Good or excellent results have been seen in other forms of palmoplantar keratoderma including mal de Meleda, Papillon-Lefèvre syndrome, erythrokeratodermia variabilis, verrucous epidermal nevi, Darier disease and pityriasis rubra pilaris. In patients with Darier disease it is wise to begin with a relatively low dosage of 0.5 mg/kg and to adjust the dosage to the further course of the disease. The same is true for the ichthyosis seen in the Netherton syndrome, which may be either a diffuse hyperkeratosis or ichthyosis linearis circumflexa. In view of the fact that any inherited keratinization disorder requires long-term treatment, the risk of bone toxicity should be carefully weighed against the benefit of this therapy. The results so far obtained indicate that the effect of etretin is comparable to that of etretinate in the treatment of inherited keratinization disorders. Intermittent therapy should be tried whenever possible. A combination therapy seems reasonable in pityriasis rubra pilaris of the adult type. We have seen good results by combination with PUVA treatment. Autosomal dominant ichthyosis vulgaris and X-linked recessive ichthyosis are inappropriate to treat with oral retinoid therapy because these diseases are too mild. Papillomatous epidermal nevi should also be excluded because they do not respond to the drug. Hailey-Hailey disease may even be worsened by this treatment. According to our experience, oral retinoid therapy has no effect in monilethrix.
Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action
Authors: Headington J.T.
Published: October 2009

The mechanism by which minoxidil, whether given orally or applied topically, stimulates hair growth remains undetermined. Possible indirect drug action, such as vasodilatation and increased blood flow to the dermal papilla, or possible local irritation related to minoxidil or to one or more components of the vehicle used for topical application has been suggested. Possible sites of direct drug action include either the dermal papilla of the follicle or hair matrix cells or possibly both. Morphometric studies of control scalp biopsies taken from young male patients with androgenetic alopecia reveal that the primary morphologic event in androgenetic alopecia is miniaturization of terminal hair follicles. Shortening and diminution of follicle size is undoubtedly accompanied by shortening of the hair growth cycle (decreased anagen time). Morphometric evaluation of scalp biopsies of patients receiving topical minoxidil in a vehicle composed of propylene glycol, water and ethanol has revealed growth of larger normally formed follicles when compared with pretreatment biopsies from the same individual. There has been no suggestion in any morphologic studies of minoxidil-treated patients for development of new follicles (follicular neogenesis). Because the dermal papilla of the hair follicle apparently controls both growth and differentiation of hair matrix cells and because there are no observable dysplastic or atypical changes in follicular germinal epithelium during or after application of topical minoxidil, it is concluded that the most probable site for the action of minoxidil is on the specialized mesenchymal cells of the follicular dermal papilla.
Etretinate Pharmacokinetics in Chronic Renal Failure
Authors: Vahlquist Anders
Published: October 2009

Chronic renal failure (CRF) interferes with the catabolism of retinol and is frequently associated with hypervitaminosis A. The effect of CRF on the plasma levels of etretinate (Tigason®, Tegison®), an aromatic retinoid, was therefore studied in 4 patients who were given the drug as part of a maintenance antipsoriatic regimen. The concentrations of the parent compound and its main metabolites (etretin and isoetretin) were monitored for 24 h after receiving a routine dose of the drug. In comparison with 4 non-CRF patients receiving similar maintenance doses of etretinate, although the CRF patients had higher peak levels of the parent compound (p < 0.01), the levels of the metabolites were similar or lower. The plasma half-lives for all compounds were approximately the same in each group, indicating that the catabolism of the drug was not affected by CRF. However, elevated etretinate concentrations may increase the drug accumulation in fat tissues and thereby prolong the time required for final elimination of the drug.
Dermatitis herpetiformis and Hemodialysis
Authors: Joly P. , Soubrane J.C. , Thomine E. , Chazerain V. , Lauret P.
Published: October 2009

A case of dermatitis herpetiformis in a 60-year-old woman with polycystic kidney disease on hemodialysis is reported. Bullous dermatoses associated with hemodialysis are analyzed.
Sweet’s Syndrome and Subacute Thyroiditis
Authors: Alcalay J. , Filhaber A. , David M. , Sandbank M.
Published: October 2009

A 63-year-old woman developed simultaneous occurrence of acute febrile neutrophilic dermatosis and subacute thyroiditis, thus suggesting that both diseases had a possible identical viral etiology. As far as we are aware, this is the first report of the association of Sweet’s syndrome and subacute thyroiditis.
Gyrate Erythema in a Patient with Dental Radicular Cyst
Authors: Monti M. , Cavicchini S. , de Bitonto A. , Caputo R.
Published: October 2009

Nonspecific gyrate erythemas (NGE) are commonly associated with hypersensitivity reactions to exogenous or endogenous antigens. A case of NGE with clinical resemblance to tinea corporis in a patient with a dental radicular cyst is reported. Cutaneous lesions disappeared after surgical excision of the dental cyst. The clinical and pathological details are described and the relationship between radicular cyst and cutaneous lesions discussed. Earlier reports are reviewed and the possibility of a focal origin is emphasized.
Perinatal Goiter with Increased Iodine Uptake and Hypothyroidism due to Excess Maternal Iodine Ingestion
Authors: de Vasconcellos Thomas Juliana , Collett-Solberg Paulo Ferrez
Published: October 2009

Background/Aims: To review cases of fetal/newborn goiter due to excess maternal iodine ingestion. Methods: We reviewed the medical records of all patients that presented with congenital goiter in 2003. We used the PubMed search engine to conduct a review of publications addressing congenital goiter and excessive iodine intake. Results: Maternal ingestion of large amounts of iodine due to an error in the manufacturing of a prenatal vitamin caused a goiter in her fetus. Seven other women who received the same prenatal vitamin had newborn children with goiters. Three of these children were hypothyroid at the time of initial examination. Three patients (2 hypothyroid and 1 euthyroid) had thyroid scans with radioactive iodine; iodine uptake was elevated (>80%) in all 3, and in 1 the perchlorate washout test was positive. Conclusion: The finding of congenital goiter and increased iodine uptake in a newborn is considered diagnostic of dyshormonogenesis, a permanent form of hypothyroidism. Our description is important because it demonstrates that iodine excess during pregnancy may mimic some forms of dyshormonogenesis. The differentiation between the two causes of newborn goiter may prevent the lifelong use of supplemental levothyroxine in patients with a transient abnormality.
Langerhans Cells in Epidermodysplasia verruciformis
Authors: Haftek Marek , Jabłońska Stefania , Szymańczyk Jacek , Jarza̧bek-Chorzelska Maria
Published: October 2009

T cell defect and anergy to contact sensitizers are characteristic of the depressed cell-mediated immunity in epidermodysplasia verruciformis (EV). In this disease the generalized infection with human papilloma viruses is associated with a high risk of skin cancers. Langerhans cell density was studied quantitatively in lesions and noninvolved epidermis of EV using OKT6 and anti-HLA-DR monoclonal antibodies with indirect immunofluorescence technique. No significant changes were found in apparently normal skin suggesting no primary defect of Langerhans cells in EV. A marked decrease in Langerhans cell number per unit of epidermal volume could be observed in EV lesions. This additional reduction of immunological surveillance at sites of potentially oncogenic human papilloma virus infection may contribute to the increased risk of malignant transformation in EV lesions.
Long-Term Actinic Damage in Sun-Exposed Vitiligo and Normally Pigmented Skin
Authors: Calanchini-Postizzi Enrica , Frenk E.
Published: October 2009

Vitiligo provides a model system for studying chronic actinic damage in skin devoid of melanin pigments and thereby permits assessment of their photoprotective function. Our study comprised 23 patients with a mean age of 67 years having stable, long-lasting vitiligo on light-exposed body regions. The vitiliginous and normally pigmented, light-exposed skin was examined clinically for manifestations of chronic actinic damage. In 11 patients skin biopsies were obtained from vitiliginous and adjacent pigmented skin for qualitative and quantitative histological comparison. Our study did not reveal evidence for a significant increase of chronic actinic damage in skin devoid of melanin pigments. These results are in agreement with the rareness of reported skin cancer in vitiligo.
Allergic Contact Dermatitis from Proprietary Topical Analgesic Sprays Containing 3-(Aminomethyl)-Pyridyl Salicylate
Authors: Schmidt Richard J. , Fernández de Corres Luis
Published: October 2009

Eleven cases of allergic contact dermatitis following the use of proprietary topical analgesic sprays (Algiospray® and Pangesic®) are described. Patch testing revealed that the adverse reactions were attributable to 3-(aminomethyl)-pyridine, which is present in these products as an ion pair with salicylic acid. The similarity between the two products investigated is not immediately apparent from the chemical nomenclature used by the manufacturers to describe the ingredients of their sprays.
Extrapituitary Neuroendocrine Melanoderma
Authors: Al Rustom K. , Gérard J. , Piérard G.E.
Published: October 2009

A patient developed an Addison-like melanoderma over the past decade. An abnormal neuropeptide related to, but bigger than pro-opiomelanocortin was found in large amount in the serum. It has most likely a stimulative action upon melanogenesis with formation of macromelanosomes.
Serum C-Reactive Protein Measurement in Pyoderma gangrenosum
Authors: Rowe I.F. , Deans A.C.
Published: October 2009

A case of pyoderma gangrenosum is reported in a patient with a past history of ulcerative colitis. Serial C-reactive protein (CRP) concentrations were measured and were found to be markedly elevated at presentation. Levels were also raised during two subsequent relapses. CRP levels proved to be a useful objective indicator of disease activity and response to therapy, and reflected changes in disease activity before the erythrocyte sedimentation rate.
Pathogenetic Studies in Chronic Urticaria
Authors: Boonk W.J. , Nieboer C. , Huijgens P.C.
Published: October 2009

To analyze the role of immune complexes, complement activation and fibrinolysis in chronic urticaria (CU), we performed serological, immunohistochemical and histopathological studies in 20 patients. In addition, the relationship to urticarial vasculitis was investigated. The results indicate that common CU is not associated with vasculitis. Neither circulating immune complexes nor immunoglobulin-complement complexes were found in the vessel walls. Lowered blood levels of complement and fibrinogen were found only in 1 and 3 patients, respectively. Alpha-2-antiplasmin and fibrin degradation products were within normal limits. Our study indicates that CU and urticarial vasculitis are separate entities. Complement activation and fibrinolysis do not appear to play an important role in CU.
Natural History of Dermatitis herpetiformis in Southern Sweden
Authors: Christensen Ole B. , Hindsén Monica , Svensson Åke
Published: October 2009

A retrospective clinical survey of 96 patients with dermatitis herpetiformis (DH) was performed in two defined populations of 425,000 in southern Sweden. The incidence of DH was 1.05–1.13/100,000 inhabitants/year and the prevalence was approximately 20–25/100,000 inhabitants. In one-third of DH patients the age at onset was > 60 years. In women with DH a strong connection to thyroid dysfunction was observed, but also other conditions of probable autoimmune pathogenesis were found in both sexes. No connection to malignant disease was observed. DH seems to be less active the later in life it starts. Several patients with DH manage without dapsone or need dapsone just occasionally in connection with bouts. This is the case even without a gluten-free diet. Many mild cases of DH were observed without a gluten-free diet; therefore, this restricting regimen should be prescribed only in more active cases of DH.
Atopic Cataract Induced by Severe Allergic Contact Dermatitis on the Face
Authors: Uehara Masami , Sato Tomoya
Published: October 2009

Although atopic cataracts commonly occur in adolescent and young adult patients with severe atopic dermatitis, we observed a 34-year-old woman with mild atopic dermatitis who abruptly developed atopic cataracts in both eyes when she suffered from severe allergic contact dermatitis on the face. This case seems to suggest that prompt control of severe dermatitis on the face in patients with atopic dermatitis is important for prevention of atopic cataract, whether the dermatitis on the face is atopic or nonatopic in nature.
Immunohistochemical Characterization of Plasma Cells in Zoon’s Balanoposthitis and (Pre)malignant Skin Lesions
Authors: Toonstra J. , van Wichen D.F.
Published: October 2009

A retrospective study in 9 patients with Zoon’s balanoposthitis was done to determine the immunoglobulin class distribution in the plasma cellular infiltrate. This was carried out on paraffin-embedded specimens using an unlabelled antibody peroxidase-antiperoxidase method. In all lesions IgG-producing plasma cells predominated. IgA- and IgD-positive cells were also present in about equal quantities but fewer than IgG. IgM-positive cells were either absent or present in very low numbers. Especially in erosive lesions a high number of plasma cells was noticed. The κ/λ ratio was variable with a preference for λ in 5 of 8 cases. These findings are suggestive of a nonspecific polyclonal stimulation of B cells, which might be caused by a persistent infection. The above-mentioned findings were compared with premalignant and malignant skin lesions in which a major amount of plasma cells was present in the inflammatory infiltrate. Comparable results were obtained with slight variations. The role of plasma cells in these infiltrates is discussed.
Prurigo pigmentosa: A Possible Mechanism of Action of Sulfonamides
Authors: Miyachi Yoshiki , Yoshioka Akira , Horio Takeshi , Imamura Sadao , Niwa Yukie
Published: October 2009

The patient described here had all the clinical features (itchy red papules and reticular pigmentation) as well as the histological findings (lichenoid tissue reactions) of prurigo pigmentosa, a little-known disorder of unknown etiology, and responded well to sulfamethoxazole treatment. In order to investigate the mode of action of this drug and thus the underlying pathogenesis of this dermatosis, the effect of sulfamethoxazole on the production of oxygen intermediates (OIs) was examined both in the cell-mediated system and in the xanthine-xanthine oxidase system. It was found that therapeutic doses of the drug significantly reduced the hydroxyl radical levels, one of the most potent oxidants that might cause tissue injury. These findings suggest the possibility that OIs produced by infiltrated cells are involved in the inflammatory process of prurigo pigmentosa and that sulfonamides exert their anti-inflammatory effects by affecting OI generation which results in protection against lichenoid tissue reaction.
Penis Tuberculides: Papulonecrotic Tuberculides on the Glans penis
Authors: Nishigori Chikako , Taniguchi Shinkichi , Hayakawd Minoru , Imamura Sadao
Published: October 2009

Two cases of penis tuberculides are described. Although this disease once used to be comparatively common in Japan, the number of people affected by the disease has recently decreased as the prevalence of tuberculosis has fallen. However, we can still find a few cases in the Japanese literature every year. Outside Japan, we can hardly find reports of this disease, except for a few cases reported under the title of ‘Papulonecrotic tuberculides on the penis’ from Northern European countries. In addition to reporting 2 cases, we summarize clinical features of this disease. Racial predisposition or endemic factors may be related to the tuberculides in such a special site.
Prophylaxis against Herpes labialis with Acyclovir Cream – a Placebo-Controlled Study
Authors: Gibson J.R. , Klaber M.R. , Harvey S.G. , Tosti A. , Jones D. , Yeo J.M.
Published: October 2009

Patients with 6 or more recurrences per year of herpes labialis were entered into a randomized, double-blind, placebo-controlled, crossover study. During the trial, they applied acyclovir cream for 16 weeks and placebo cream for 16 weeks to all previously affected areas 4 times per day, and were subsequently observed for a further 16 weeks with no treatment. Results from the 23 evaluable cases showed that although recurrences did occur whilst on acyclovir treatment, patients suffered from significantly fewer days of disease and significantly fewer attacks of cold sores when compared with placebo.
The Immunohistochemical Observation of Somatostatin-Like and Avian Pancreatic Polypeptide-Like Immunoreactivity in Certain Cellular Elements of Diabetic Lipodystrophic Skin
Authors: Johansson O. , Nordlind K. , Efendić S. , Lidén S.
Published: October 2009

Somatostatin-like and avian pancreatic polypeptide-like immunoreactivities were found to occur within certain cellular elements of the dermis of a patient having diabetic lipodystrophic skin lesions. No specific immunofluorescence could be seen in the epidermis.
Lymphocyte Transformation Test in Patients with American Leishmaniasis
Authors: Pagnano Paulo M.G. , da Costa João Carlos , Bechelli Luiz M.
Published: October 2009

To determine the correlation between the lymphocyte transformation test (LTT) with phytohemagglutinin (PHA) and the clinical forms of American leishmaniasis (AL), duration of the disease and reaction to leishmanin, the authors studied 12 patients and compared them to 25 unaffected individuals. The ulcerated cutaneous form of the disease was observed in 4 patients, the ulcero-nodular lymphangitic form in 1 the mucous cutaneous form with destruction of the nose in 6, and the verrucous form in 1. General patient condition was satisfactory and the Montenegro reaction macroscopically positive with infiltrations of 5–15 mm in diameter. The results revealed no evidence of immunodeficiency among patients. No correlation was observed between clinical forms, duration of the disease and Montenegro reaction and LTT results. LTT with PHA does not appear to be an adequate indicator of the cell immune system in AL cases.
Primary Biliary Cirrhosis Associated with Coeliac Disease and Dermatitis herpetiformis
Authors: Gabrielsen T.O. , Hoel P.S.
Published: October 2009

A 69-year-old man who 1 year previously got the diagnosis primary biliary cirrhosis presented a highly pruritic rash on the knees, elbows and in the inguinal region. Both clinically and histologically this was compatible with dermatitis herpetiformis, and dapsone treatment confirmed this. He was found to have jejunal atrophy, and after 1 year with gluten-free diet, biopsy showed almost full restoration of the villous pattern. He then only rarely had any skin problems.
Trichophyton-rubrum-lnfected Toenails Treated with Ketoconazole and Partial Nail Avulsion
Authors: Kavli G. , Midelfart K. , Moseng D. , Stenvold S.E. , Falk E.S. , Wisløff Nilssen J. , Volden G.
Published: October 2009

30 patients with totally 178 toenails infected with Trichophyton rubrum were randomly treated with ketoconazole alone for 4 months (group A) or in combination with chemical nail avulsion (group B). Of the 14 patients in group A who completed the treatment, 4 (28%) were cured 6 months later, compared to 8 (53%) of 15 patients in group B. In 4 cases, transient elevated hepatofunction enzymes occurred. Gastrointestinal disturbances caused withdrawal in 1 case.
Serum Ferritin Levels in Patients with Porphyria cutanea tarda
Authors: Disler P.B. , Lee G.K. , Blekkenhorst G.H. , Jacobs P. , Graves J.
Published: October 2009

Serum ferritin was measured in 9 patients with overt porphyria cutanea tarda. In 6, the level was higher than normal. We confirm that moderate, but not gross iron overload is a feature of such patients.
Parameters of Cell-Mediated Immunity in Recurrent Herpes simplex
Authors: Georgala S. , Avgerinou G. , Perdikari P. , Vareltzidis A.
Published: October 2009

Cell-mediated immunity was studied by a leukocyte migration inhibition assay, tuberculin, and a DNCB skin test in 32 patients with recurrent herpes simplex infection and in 34 healthy individuals who served as controls. Migration inhibition was found to be significantly reduced in patients who had suffered from recurrences for more than 1 year as compared to the controls. DNCB and tuberculin sensitivity were also found to be impaired in the group with infections of long duration. The data presented suggest a functional defect in cell-mediated immunity in individuals suffering from recurrent herpes simplex which could be responsible for the relapses.
Etat poïkilodermique et tolamolol
Authors: Fierens F. , Bourlond A. , Clerens A. , Guilmot-Bruneau M.M. , Defresne C.
Published: October 2009

Long-term ingestion of tolamolol led to severe poikiloderma with microscopic features similar to those of premycosis.
Lymphocyte Studies in Behçet’s Syndrome
Authors: Ahmed Razzaque
Published: October 2009

Subsets of lymphocytes from 14 patients with Behçet’s syndrome, during the active stage of the disease, were studied. Circulating T cells, B cells and Fc receptor-bearing cells in the peripheral blood were compared to 20 age- and sex-matched controls. Patients with Behçet’s syndrome have decreased levels of T cells (p value < 0.05) and normal levels of B cells, and decreased PHA response. This study further supports the concept that there are defects of cell-mediated immunity in patients with Behçet’s syndrome.
Generalized Acanthosis nigricans
Authors: Andreev V.C. , Boyanov L. , Tsankov N.
Published: October 2009

A patient suffering from an advanced and inoperable gastric carcinoma developed an unusual paraneoplastic syndrome, consisting of intensive pruritus, acanthosis nigricans, sign of Leser-Trélat (seborrhoic keratoses and freckles), warty and papillomatous excrescences, palmoplantar hyperkeratosis and florid papillomatous and granular lesions of the mouth mucosa. The whole skin of the patient was involved. The authors believe this disorder to be generalized acanthosis nigricans. As a cause they suggest the possibility of a growth-stimulating factor, produced by the tumor cells. The relationship of acanthosis nigricans with the sign of Leser-Trélat is discussed.
Primary Cutaneous Amyloidosis: Clinical, Laboratorial and Histopathological Study of 25 Cases
Authors: Habermann Marta C. , Montenegro Mario R.
Published: October 2009

25 cases of primary cutaneous amyloidosis are studied. 16 patients had macular amyloidosis (MPA) and 9 lichen amyloidosus (LPA). γ-Globulins were increased in 50% of the patients. IgG and IgA were increased in the serum of 5 and 3 patients with MPA and 4 and 2 patients with LPA, respectively. Volume of amyloid deposits was similar in both forms. By direct immunofluorescence we demonstrated IgG in the amyloid deposits of 21 of the 25 cases and C3 in 13; IgM was present in 9 cases of MPA and in 3 cases of LPA. MPA was more frequent than LPA; histologically, it was impossible to distinguish MPA from LPA; correlation between serum levels of γ-globulins and their presence in amyloid deposits was weak; MPA and LPA seem to be distinct clinical manifestations of the same disease and itching does not cause transformation of MPA in LPA.
Epidermal Hyperplasia Induced in Guinea Pig Flank Skin by Intradermal Injection of Sudan Red
Authors: Stenn K.S.
Published: October 2009

Studies of dermal-epidermal interactions were conducted with guinea pig flank skin and intradermal injections of the irritant, Sudan IV dye in olive oil. These injections led to epidermal hyperplasia in areas overlying the irritant and the effect was most significant when the irritant was placed in the upper dermis. Basal cell mitotic activity and thymidine uptake reached a peak by 24 h and thereafter dropped rapidly. Maximal epidermal thickness (4.3 times the control) resulting from an increase in cell number occurred within 2–4 days. Despite the very short period of increased cell growth, epidermal thickness returned to control values only after a 24-day period. A similar growth response could not be induced by saline injections. A single topical application of the irritant showed a qualitatively and quantitatively different epidermal response. These experiments indicate that an intradermal irritant can lead to epidermal hyperplasia and a long-lasting epidermal thickening.
Hamartome folliculaire multiple familial
Authors: Delacrétaz J. , Balsiger F.
Published: October 2009

Multiple cystic and proliferative follicular lesions localized on the face and the genitalia of several members of an Italian family are described. Transmission seems to be autosomal dominant, with weak penetration and variable expressivity.
Aspects histologiques des mycoses provoquées par les champignons opportunistes
Authors: Destombes P.
Published: October 2009

The histological study with Hotchkiss-Mc Manus staining and Grocott silver impregnation of tissues invaded by opportunistic fungi is a rapid and easy means of diagnosis. The inflammatory reactions around the fungus give the certitude that it is a pathogen and not a contaminant. The major opportunists among Candida, Aspergillus, Mucor, Absidia and Cryptococcus species are presented in local and disseminated lesions, but all fungi, saprophytic in the normal host, can become pathogens in the immunodepressed patient.
Ostéome perforant
Authors: Delacrétaz J. , Koenig R.
Published: October 2009

Three osteomas had spontaneously appeared on the lateral side of the arm in a 44-year-old woman; one of them showed a slight depression in its center and proved histologically to be an osteoma perforans.
2-Chloroethanol – Percutaneous Toxicity of a Solvent
Authors: Wahlberg Jan E. , Boman Anders
Published: October 2009

This report is a part of a comparative study where skin pathology, blood concentrations and percutaneous toxicity after epicutaneous administration of solvents are investigated. The method used for the study of percutaneous toxicity proved capable of differentiating between different applied amounts of 2-chloroethanol. This solvent was found to be highly toxic, even 0.10 ml killed all 20 exposed animals within 24 h. A 35% aqueous solution killed about half of the animals, while a 10% solution killed only 1 out of 20. A comparative study with intraperitoneal administration of the same amounts as epicutaneously, showed that the mortality and mean time until death diminished with rising amounts (with only one exception).
Manifestations cutanées provoquées par le lithium
Authors: Reiffers Josée , Dick Pierre
Published: October 2009

This paper describes the cutaneous side-effects which appeared in 5 patients under Lithium medication for manic-depressive disease: 2 cases with facial and dorsal acne, 1 case with generalized pruritus with burning sensations on the tongue and tumefaction of the lips, 1 case with endogenous generalized psoriasis and 1 case with palmo-plantar hyperkeratosis, ichthyosis and associated with euthyroid goitre. The lithium content of the tissues was assayed by flame spectrophotometry of calcinated biopsy material taken from the epidermis, the dermis and the subcutaneous adipose tissue from 4 of our 5 cases. An experimental investigation was carried out in guinea pigs fed with lithium salts during 6 months. The cation was assayed in samples of epidermis, dermis and perirenal adipose tissue. A study of the accumulation of lithium in epidermal, dermal and adipose tissue is thus added to the studies already published regarding the accumulation of this ion in other tissues.
Age-Related Changes in the Reducible Cross-Links of Human Dermis Collagen
Authors: Volpin D. , Giro M.G. , Castellani I. , Peserico A.
Published: October 2009

Samples of normal human dermis of different ages are reduced with tritiated sodium borohydride and changes of major reducible cross-links are compared as a function of chronological age. While lysinonorleucine practically remains constant, reduced desmosine changes slightly, hydroxylysinonorleucine and dihydroxylysinonorleucine display a marked decrease with age. An unknown compound is shown to increase with aging. The data suggest a correlation between the change of aldimine cross-links and the structural and/or biochemical changes occurring with increase in age.
Hautpilze in Mischkultur
Authors: Fischer Emil
Published: October 2009

The macroscopic and micromorphologic characteristics of mixed cultures of skin fungi are being discussed.
Erythema Multiforme in Association with Active Ulcerative Colitis and Crohn’s Disease
Authors: Chapman R.S. , Forsyth Angela , MacQueen A.
Published: October 2009

Erythema multiforme of vesiculo-bullous type is described in one patient at the onset of ulcerative colitis and in another during an exacerbation of Crohn’s disease. Inflammatory large bowel disease should be once more accepted as a cause of erythema multiforme in its own right, presumably mediated through an immunological reaction.
Régression des tumeurs cutanées expérimentales de la souris sous l’effet de deux dérives de l’acide adenosine- 3’,5’-monophosphorique
Authors: Posternak F. , Orusco M. , Csank-Brassert J. , Cox J. , Posternak T. , Laugier P.
Published: October 2009

N6,2’O-dibutyryl-cAMP and N6,2’O-8-thio-cAMP produced a favourable effect on skin tumours in mice induced by dimethyl-benzanthracene.
Onset of the Vasoconstrictor Effect of Diflucortolone Valerate, Betamethasone Valerate, and Fluocinolone Acetonide Ointments Applied for Varying Periods under Occlusive Dressings
Authors: Szadurski J. , Renz F. , Gasser D.
Published: October 2009

Evaluation of cutaneous vasoconstriction after applications of varying duration of topical corticoids on the flexor surfaces of the forearms of 20 patients with intact skin shows a significantly faster blanching effect with diflucortolone valerate ointment than with fluocinolone acetonide and betamethasone valerate ointments. Furthermore, the test shows that even for a highly active preparation, such as the diflucortolone valerate ointment, an application time of less than 3 h only exceptionally leads to vasoconstriction in the healthy skin.
Hyperkeratosis Lenticularis Persians (Flegel)
Authors: Frenk E. , Tapernoux B.
Published: October 2009

The hitherto reported cases of hyperkeratosis lenticularis perstans are reviewed. The clinical, light- and electron-microscopical features of an additional case with a positive family history are reported. Hyperkeratosis lenticularis perstans appears to be characterized by a unique ultrastructural alteration, lack of Odland bodies in the epidermis underlying the keratotic papule.
Difference in the Efficiency of Two Delivery Forms of 8-Methoxypsoralen
Authors: Polano M.K. , Schothorst A.A.
Published: October 2009

In a clinical test 8-MOP Basotherm (Meladinine®) proved to be more efficient than 8-MOP Sigma prepared by our hospital pharmacy, as a photosensitizer in the PUVA treatment. This difference is significant (p = 0.002).
Lithium Acne
Authors: Okrasinski Henrik
Published: October 2009

A young woman aged 21 developed acne eruption after 3 weeks treatment with lithium carbonate.
Dihydroxyacetone Naphthoquinone Protection against Photosensitivity
Authors: Rice Edwin G.
Published: October 2009

30 patients with multiple types of sunlight sensitivity were treated successfully with DHA/lawsone sunscreen. This sunscreen was able to protect all patients even though their photosensitivities were in different parts of the ultraviolet and visible spectrum. About 80% of the patients experienced sufficient protection during the summer months to lead a virtually normal life-style while participating in all kinds of outdoor activities.
Progressive Systemic Sclerosis (Scleroderma)
Authors: Ladipo G.O.A.
Published: October 2009

The first case of progressive systemic sclerosis in a Nigerian is described. In addition to the typical features of the disease, the case shows affection of the peripheral nerves, a very rare complication. The latter led to a mistaken diagnosis of leprosy. The reasons for the rarity of this disorder in the indigenous Africans and its differentiating features from leprosy are discussed.
Efficacy of Bufexamac (NFN) Cream in Skin Diseases
Authors: Christiansen J.V. , Gadborg E. , Kleiter I. , Ludvigsen K. , Meier C.H.K. , Nørholm A. , Reiter H. , Reymann F. , Raaschou-Nielsen W. , Søndergaard M. , Unna P. , Wehnert R.
Published: October 2009

The effect of a new non-steroid anti-inflammatory substance (bufexamac) in a special constituent was compared with that of 0.1% triamcinolone acetonide, 1% hydrocortisone cream, and placebo during a double-blind multicentre trial. The clinical effect of these four creams was studied in 193 patients receiving treatment for the following skin disorders: atopic dermatitis, allergic contact dermatitis, and non-allergic contact dermatitis, as well as dermatitis seborrheica. After 2 and 4 weeks’ treatment, when 193 and 157 patients, respectively, were re-examined, the effect of triamcinolone acetonide and hydrocortisone cream was significantly better, than that obtained with bufexamac in the cream basis employed. On the other hand, no statistically significant difference in effect between bufexamac and placebo cream was observed.