bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Synthesis of Novel 6,7‐Dihydrobenzo[d]isoxazol‐4(5H)‐one Derivatives Bearing 1,2,3‐Triazole Moiety as Potential Hsp90 Inhibitors and their Evaluation as Antiproliferative Agents
Authors: Varabyeva Nastassia A. , Salnikova Diana I. , Krymov Stepan K. , Bogdanov Fedor B. , Shchekotikhin Andrey E. , Puzanau Raman M. , Sorokin Danila V. , Lakhvich Fedor A. , Scherbakov Alexander M. , Piven Yuri A.
Published: March 2024

An effective approach to 5‐triazolyl‐substituted 6,7‐dihydrobenzo[d]isoxazol‐4(5H)‐ones and 4,5,6,7‐tetrahydrobenzo[d]isoxazoles was developed. The approach included α‐keto bromination of 6,7‐dihydrobenzo[d]isoxazol‐4(5H)‐one followed by nucleophilic substitution of bromine with the azide group. For the preparation of 5‐azido‐6,7‐dihydrobenzo[d]isoxazol‐4(5H)‐one, the carbonyl group at position 4 was reduced to a methylene group under ionic hydrogenation conditions using triethylsilane as a reducing agent. Cu(I)‐catalyzed [2+3] cycloaddition of terminal alkynes to both obtained azides was used for the synthesis of two series of triazolyl derivatives. Compounds, which contain in their structures common for some Hsp90 inhibitors 2,4‐dihydroxy‐5‐isopropylphenyl fragment, were evaluated as antiproliferative agents against two breast cancer cell lines: hormone‐dependent MCF7 and HER2‐positive HCC1954. The lead compound showed half‐maximal inhibitory concentration (IC50) values below 5 μM and induced significant changes in the Hsp90 signaling pathways in HER2‐positive HCC1954 cells. It increased the expression of Hsp70 (used as a pharmacodynamic marker of Hsp90 inhibition) and inhibited the expression of HER2, p‐c‐Met, c‐Met, and p‐AKT. The combination of the selected isoxazole‐triazole hybrid molecule and the earlier described apoptosis inducer LCTA‐3344 demonstrated a significant antiproliferative effect against HCC1954 cells. The lead compound was revealed to be a promising candidate for future anticancer drug design, particularly against aggressive breast cancer positive for HER2.
Effect of CTAB premicelle and micelle formation on Bromophenol Blue spectra
Authors: Zheng Junyu , Ma Zongbin , Zhang Qi , Qiu Lu , Wang Zhihang , Wang Nong
Published: March 2024

The interactions between surfactants and dyes in aqueous solutions are essential for gaining insights into dyeing processes across various industries and for driving advancements in chemical research. This paper investigates the interaction between the anionic dye bromophenol blue (BPB) and the cationic surfactant cetyltrimethylammonium bromide (CTAB) in aqueous solutions. It was observed that the absorbance value at the maximum absorption peak of BPB changes systematically with increasing CTAB concentration, revealing the critical premicelle concentration (cpc) and critical micelle concentration (cmc) of CTAB. Employing a micellization model and measuring the electric conductivity across different concentrations of CTAB, the micellization thermodynamic parameters of CTAB, both in the absence and presence of BPB, were determined. The findings indicate that the associative interaction between BPB and CTAB significantly influences the formation of CTAB micelles.
Synthesis of Novel MOF‐Based BixTiy‐BTC and Bi1Ti3‐BTC/Fe3O4 Photocatalysts and Their Application in the Degradation of UDMH in Wastewater
Authors: Zhou Feng , Xie Chen , Huo Yonggang , Yao Qingxu
Published: March 2024

Removal of organic pollutants from wastewater remains a significant challenge. Hence, we report a series of novel MOFs based BixTiy‐BTC photocatalysts synthesized by hydrothermal method for decontamination of 1,1‐Dimethylhydrazine (UDMH). The preparation parameters of MOFs were optimized, the best catalytic performance was achieved by adjusting the Bi/Ti molar ratio to 1 : 3, with Bi1Ti3‐BTC a photocurrent density of 0.35 mA/cm2 was reached. The morphology and composition of the materials were analyzed, titanium doping increased the specific surface area. Bi1Ti3‐BTC was loaded with magnetic nano‐Fe3O4, which prevented agglomeration of Bi1Ti3‐BTC and increased the specific surface area, thus improving photocatalytic activity. The band gap structure of the semiconductor materials was estimated by UV‐Vis and XPS valence band spectra, while the separation efficiency of photogenerated carriers was investigated by photocurrent density and PL (Photoluminescence) spectrum. The photocatalytic degradation rate of UDMH rapidly decreased after addition of EDTA, indicating that h+ was the main active species in the photocatalytic degradation process. The photocatalytic removal efficiency of UDMH with Bi1Ti3‐BTC/Fe3O4 at a concentration of 0.5 g/L reached 97.58 % after illumination for 180 min, and after 210 min near quantitative degradation was observed.
Multifunctional Gold Nanozyme‐Engineered Amphotericin B for Enhanced Antifungal Infection Therapy
Authors: Jiang Chunmei , Li Fangping , Song Pei , Wen Mengyao , Yang Saixue , Tian Geng , Shao Dongyan , Shi Junling , Shang Li
Published: March 2024

Chronic wounds of significant severity and acute injuries are highly vulnerable to fungal infections, drastically impeding the expected wound healing trajectory. The clinical use of antifungal therapeutic drug is hampered by poor solubility, high toxicity and adverse reactions, thereby necessitating the urgent development of novel antifungal therapy strategy. Herein, this study proposes a new strategy to enhance the bioactivity of small‐molecule antifungal drugs based on multifunctional metal nanozyme engineering, using amphotericin B (AmB) as an example. AmB‐decorated gold nanoparticles (AmB@AuNPs) are synthesized by a facile one‐pot reaction strategy, and the AmB@AuNPs exhibit superior peroxidase (POD)‐like enzyme activity, with maximal reaction rates (Vmax) 3.4 times higher than that of AuNPs for the catalytic reaction of H2O2. Importantly, the enzyme‐like activity of AuNPs significantly enhanced the antifungal properties of AmB, and the minimum inhibitory concentrations of AmB@AuNPs against Candida albicans (C. albicans) and Saccharomyces cerevisiae (S. cerevisiae) W303 are reduced by 1.6‐fold and 50‐fold, respectively, as compared with AmB alone. Concurrent in vivo studies conducted on fungal‐infected wounds in mice underscored the fundamentally superior antifungal ability and biosafety of AmB@AuNPs. The proposed strategy of engineering antifungal drugs with nanozymes has great potential for enhanced therapy of fungal infections and related diseases.
Electronic Properties of CrB/Co2CO2 Superlattices by Multiple Descriptor‐Based Machine Learning Combined with First‐Principles
Authors: Yuan Yuanyuan , Ren Junqiang , Xue Hongtao , Li Junchen , Tang Fuling , Guo Xin , Lu Xuefeng
Published: March 2024

In recent times, newly unveiled 2D materials exhibiting exceptional characteristics, such as MBenes and MXenes, have gained widespread application across diverse domains, encompassing electronic devices, catalysis, energy storage, sensors, and various others. Nonetheless, numerous technical bottlenecks persist in the development of high‐performance, structurally flexible, and adjustable electronic device materials. Research investigations have demonstrated that 2D van der Waals superlattices (vdW SLs) structures comprising materials exhibit exceptional electrical, mechanical, and optical properties. In this work, the advantages of both materials are combined and compose the vdW SLs structure of MBenes and MXenes, thus obtaining materials with excellent electronic properties. Furthermore, it integrates machine learning (ML) with first‐principles methods to forecast the electrical properties of MBene/MXene superlattice materials. Initially, various configurations of MBene/MXene superlattice materials are explored, revealing that distinct stacking methods exert significant influence on the electronic structure of MBene/MXene materials. Specifically, the BABA‐type stacking of CrB (layer A) and Co2CO2 MXene (layer B) is most stable configureation. Subsequently, multiple descriptors of the structure are constructed to predict the density of states  of vdW SLs through the employment of ML techniques. The best model achieves a mean absolute error (MAE) as low as 0.147 eV.
Flexural stiffness of RC beams with high‐strength steel bars after exposure to elevated temperatures
Authors: Zhao Jun , Jiang Yibo , Cai Gaochuang , Deng Xiangsheng , Si Larbi Amir
Published: March 2024

In this paper, the flexural stiffness of the reinforced concrete (RC) beams reinforced with high‐strength steel bars after exposure to different elevated temperatures was investigated experimentally and theoretically. The effects of the elevated temperature (room temperature, 200°C, 400°C, 600°C, 800°C, and 1000°C), high‐temperature duration time (0 h, 1 h, and 2 h), and steel bar types (HRB600 and HRB500) on the load–deflection response, load–stiffness response, and crack distribution of tested beams were investigated. The results showed that when the temperature is below 600°C, the effect of high temperature on the stiffness reduction of high‐strength RC beams is not significant, while the beams reduced the stiffness when the exposure temperature reached 800°C and 1000°C, regardless of the type of the steel bars. The elevated temperature accelerated the development of the deflection of RC beams, and the bending stiffness of the RC beams decreased more severely as the increase of duration time. By using appropriate degradation factors, the residual stiffness of the beams was predicted well by the analysis calculation method and the effective inertia moment calculation method, for example, the prediction accuracy is over 91% and 85.8% for the cases under and over 800°C, respectively. However, for the beams at 1000°C, a correction coefficient (0.652) was applied to improve the accuracy of the calculative stiffness of the HRB600 RC beams at the service load stage.
Artificial Intelligence-Based Counting Algorithm Enables Accurate and Detailed Analysis of the Broad Spectrum of Spot Morphologies Observed in Antigen-Specific B-Cell ELISPOT and FluoroSpot Assays
Authors: Karulin Alexey Y. , Katona Melinda , Megyesi Zoltán , Kirchenbaum Greg A. , Lehmann Paul V.
Published: March 2024

Antigen-specific B-cell ELISPOT and multicolor FluoroSpot assays, in which the membrane-bound antigen itself serves as the capture reagent for the antibodies that B cells secrete, inherently result in a broad range of spot sizes and intensities. The diversity of secretory footprint morphologies reflects the polyclonal nature of the antigen-specific B cell repertoire, with individual antibody-secreting B cells in the test sample differing in their affinity for the antigen, fine epitope specificity, and activation/secretion kinetics. To account for these heterogeneous spot morphologies, and to eliminate the need for setting up subjective counting parameters well-by-well, CTL introduces here its cutting-edge deep learning-based IntelliCount™ algorithm within the ImmunoSpot® Studio Software Suite, which integrates CTL’s proprietary deep neural network. Here, we report detailed analyses of spots with a broad range of morphologies that were challenging to analyze using standard parameter-based counting approaches. IntelliCount™, especially in conjunction with high dynamic range (HDR) imaging, permits the extraction of accurate, high-content information of such spots, as required for assessing the affinity distribution of an antigen-specific memory B-cell repertoire ex vivo. IntelliCount™ also extends the range in which the number of antibody-secreting B cells plated and spots detected follow a linear function; that is, in which the frequencies of antigen-specific B cells can be accurately established. Introducing high-content analysis of secretory footprints in B-cell ELISPOT/FluoroSpot assays, therefore, fundamentally enhances the depth in which an antigen-specific B-cell repertoire can be studied using freshly isolated or cryopreserved primary cell material, such as peripheral blood mononuclear cells.
Critical Pedagogy in North American Food Systems Planning: Looking Back to Look Ahead
Authors: Mendes Wendy
Published: March 2024

The purpose of this chapter is to revisit, and build upon, themes that emerged from a 2011 article on food systems pedagogy in the discipline of planning (Mendes & Nasr). The chapter begins with an overview of findings that emerged from the 2011 article. This is followed by a consideration of how the literature on food systems pedagogy in planning and related disciplines is evolving, and what has held true in the intervening years. Four themes are identified from the literature since 2011: interdisciplinarity, social justice and ethics, community-university research partnerships, and systems thinking. The themes are intended to serve as signposts to signal a bridge between early concerns of food system planning educators, and the new or additional skills and capacities that may be needed to prepare future food systems planners and community leaders.
Introduction: Social Accountability and Civic Innovation in the Arab World
Authors: Vloeberghs Ward , Bergh Sylvia I.
Published: March 2024

The Middle East and North Africa region has been absent form stocktaking exercises on social accountability initiatives (SAI), an umbrella term to designate citizen-led tools aimed at socio-political change. We argue that this sidelining is unwarranted, given the proliferation of participatory governance initiatives, civic associations and popular mobilisation in Arab societies after 2011. Whereas the struggle for improved accountability in the Arab world remains under-researched, analysis of authoritarian regime tactics has proliferated. The fact is, however, that many Arab societies have experimented with mechanisms to apply political pressure on corrupt elites while international donors have launched diverse SAIs, including community score cards and participatory and gender-responsive budgeting initiatives. In this chapter, we first identify this double gap: not only has the literature on SAIs overlooked the MENA region but scholarship on the Middle East has largely failed to recognise initiatives launched across the region over the past decade as SAIs. Then, we aim to address the blind spot of Arab SAI’s as pathways towards improved governance. Finally, we present an overview of extant literature and introduce a set of four research questions to better understand what social accountability means for people on the ground. These questions focus on the various meanings of social accountability (musā’ala vs muhāsaba), its modes of mobilisation, the responses from authorities to such initiatives and their overall outcomes.
Wie sichern wir in Zukunft die Versorgung von Kindern und Jugendlichen mit psychischen Erkrankungen?
Authors: Romanos Marcel , Berg Gundolf , Brauer Annegret , Jung Martin , Klein Marianne , Kölch Michael , Schepker Renate
Published: March 2024

Kinder und Jugendliche mit psychischen Störungen weisen komplexe Bedarfe auf, die regelhaft Leistungen aus mehreren Sozialgesetzbüchern erforderlich machen und innerhalb der medizinischen Versorgung Leistungen aus verschiedenen Sektoren bedingen können. Die steigende Inanspruchnahme, die Zunahme der Schweregrade der Störungsbilder sowie der fachübergreifende Personalmangel belasten die Strukturen der interdisziplinären Versorgungsnetzwerke. Die Folge sind lange Wartezeiten, lange Wegstrecken und regionale Unterversorgung. Das Fachgebiet der Kinder- und Jugendpsychiatrie und -psychotherapie (KJPP) nimmt die zentrale und koordinative Rolle in der kooperativen Versorgung von Kindern und Jugendlichen mit psychischen Erkrankungen ein. Die KJPP weist angesichts der zunehmenden Herausforderungen Reformbedarf auf, welcher sich von dem der somatischen Versorgungsstrukturen, aber ebenso von denen der Psychiatrie und Psychotherapie bzw. der Psychosomatik unterscheidet. Das vorliegende Diskussionspapier beschreibt die Besonderheiten der KJPP-Strukturen, die Reformbedarfe und Lösungsmöglichkeiten durch Abbau von Sektorengrenzen in der Patientenversorgung, in der Weiterbildung sowie im Personaleinsatz, durch Intensivierung der Vernetzung, durch stärkere Nutzung von Telemedizin sowie durch Aufbau evidenzbasierter Prävention und Früherkennung.
Task-irrelevant decorative pictures increase cognitive load during text processing but have no effects on learning or working memory performance: an EEG and eye-tracking study
Authors: Scharinger Christian
Published: March 2024

Decorative pictures (DP) are often used in multimedia task materials and are commonly considered so-called seductive details as they are commonly not task-relevant. Typically, DP result in mixed effects on behavioral performance measures. The current study focused on the effects of DP on the cognitive load during text reading and working memory task performance. The theta and alpha frequency band power of the electroencephalogram (EEG) and pupil dilation served as proxies of cognitive load. The number of fixations, mean fixation durations, and the number of transitions served as proxies of the attentional focus. For both, text reading and n-back working memory tasks, the presence and congruency of DP were manipulated in four task conditions. DP did neither affect behavioral performance nor subjective ratings of emotional–motivational factors. However, in both tasks, DP increased the cognitive load as revealed by the EEG alpha frequency band power and (at least to some extent) by subjective effort ratings. Notably, the EEG alpha frequency band power was a quite reliable and sensitive proxy of cognitive load. Analyzing the EEG data stimulus-locked and fixation-related, the EEG alpha frequency band power revealed a difference in global and local cognitive load. In sum, the current study underlines the feasibility and use of EEG for multimedia research, especially when combined with eye-tracking.
Die Geschichte der Psychosomatik in Österreich
Authors: Scheer Peter J.
Published: March 2024

Die Psychosomatik entwickelte sich nach der Wiederentdeckung der Psychoanalyse in den siebziger Jahren des 20. Jahrhunderts in Österreich langsam weiter. Leitfigur dieser Zeit war Erwin Ringel, Pionier der Suizidprävention und erster Ordinarius für Psychosomatik an der psychiatrischen Universitätsklinik in Wien. Die allgemeinverständliche Ausdrucksweise und Laienpublikationen machte die neue Denke populär. Erwin Ringel wollte die Psychosomatik als Prinzip jedes medizinischen Fachs und nicht als eine neue Fachrichtung installieren. So richtig sein Ansatz war, so sehr behinderte er die Entwicklung dieses Fachs, weil es lange keinen „Platz“ im Kanon der Sonderfächer fand. In der Pädiatrie richtete Hans Zimprich am Karolinen-Kinderspital in Wien eine psychosomatische Station ein: Junge, begeisterte Ärztinnen und Ärzte wurden psychosomatisch handelnde Pädiater. Das Team wurde von einer Psychoanalytikerin und einem Psychiater ergänzt. Wir machten erste Schritte, starteten mit Kindern, die an Enuresis nocturna litten, die damals mit Imipramin, einem trizyklischen Antidepressivum (Imipramin [Tofranil®] kann schon bei normaler Dosierung kardiotoxisch sein; 1980 wurde empfohlen, es bei der an sich harmlosen Störung Enuresis noct. hoch zu dosieren) mit hoher Toxizität und/oder mit Klingelmatratze versorgt wurden. Das war gefährlich und half nicht. Das für Österreich Neue, die psychodynamische Denkweise, eroberte viele Gebiete der Medizin und setzte Psychodynamik an die Stelle von klassischer Psychiatrie. Niederschwelligkeit und inmitten der klassischen Pädiatrie sein – das war der Traum.
A systematic review and research challenges on phishing cyberattacks from an electroencephalography and gaze-based perspective
Authors: Thomopoulos George A. , Lyras Dimitrios P. , Fidas Christos A.
Published: March 2024

Phishing is one of the most important security threats in modern information systems causing different levels of damages to end-users and service providers such as financial and reputational losses. State-of-the-art anti-phishing research is highly fragmented and monolithic and does not address the problem from a pervasive computing perspective. In this survey, we aim to contribute to the existing literature by providing a systematic review of existing experimental phishing research that employs EEG and eye-tracking methods within multi-modal and multi-sensory interaction environments. The main research objective of this review is to examine articles that contain results of at least one EEG-based and/or eye-tracking-based experimental setup within a phishing context. The database search with specific search criteria yielded 651 articles from which, after the identification and the screening process, 42 articles were examined as per the execution of experiments using EEG or eye-tracking technologies in the context of phishing, resulting to a total of 18 distinct papers that were included in the analysis. This survey is approaching the subject across the following pillars: a) the experimental design practices with an emphasis on the applied EEG and eye-tracking acquisition protocols, b) the artificial intelligence and signal preprocessing techniques that were applied in those experiments, and finally, c) the phishing attack types examined. We also provide a roadmap for future research in the field by suggesting ideas on how to combine state-of-the-art gaze-based mechanisms with EEG technologies for advancing phishing research. This leads to a discussion on the best practices for designing EEG and gaze-based frameworks.
Muscle and joint mechanics during maximum force biting following total temporomandibular joint replacement surgery
Authors: Woodford Sarah C. , Robinson Dale L. , Abduo Jaafar , Lee Peter V. S. , Ackland David C.
Published: March 2024

Total temporomandibular joint replacement (TMJR) surgery is the established treatment for severe temporomandibular joint disorders. While TMJR surgery is known to increase mouth-opening capacity, reduce pain and improve quality of life, little is known about post-surgical jaw function during activities of daily living such as biting and chewing. The aim of this study was to use subject-specific 3D bite force measurements to evaluate the magnitude and direction of joint loading in unilateral total TMJR patients and compare these data to those in healthy control subjects. An optoelectronic tracking system was used to measure jaw kinematics while biting a rubber sample for 5 unilateral total TMJR patients and 8 controls. Finite element simulations driven by the measured kinematics were employed to calculate the resultant bite force generated when compressing the rubber between teeth during biting tasks. Subject-specific musculoskeletal models were subsequently used to calculate muscle and TMJ loading. Unilateral total TMJR patients generated a bite force of 249.6 ± 24.4 N and 164.2 ± 62.3 N when biting on the contralateral and ipsilateral molars, respectively. In contrast, controls generated a bite force of 317.1 ± 206.6 N. Unilateral total TMJR patients biting on the contralateral molars had a significantly higher lateral TMJ force direction (median difference: 63.6°, p = 0.028) and a significantly lower ratio of working TMJ force to bite force (median difference: 0.17, p = 0.049) than controls. Results of this study may guide TMJ prosthesis design and evaluation of dental implants.
Does ‘summative’ count? The influence of the awarding of study credits on feedback use and test-taking motivation in medical progress testing
Authors: van Wijk Elise V. , van Blankenstein Floris M. , Donkers Jeroen , Janse Roemer J. , Bustraan Jacqueline , Adelmeijer Liesbeth G. M. , Dubois Eline A. , Dekker Friedo W. , Langers Alexandra M. J.
Published: March 2024

Despite the increasing implementation of formative assessment in medical education, its’ effect on learning behaviour remains questionable. This effect may depend on how students value formative, and summative assessments differently. Informed by Expectancy Value Theory, we compared test preparation, feedback use, and test-taking motivation of medical students who either took a purely formative progress test (formative PT-group) or a progress test that yielded study credits (summative PT-group). In a mixed-methods study design, we triangulated quantitative questionnaire data (n = 264), logging data of an online PT feedback system (n = 618), and qualitative interview data (n = 21) to compare feedback use, and test-taking motivation between the formative PT-group (n = 316), and the summative PT-group (n = 302). Self-reported, and actual feedback consultation was higher in the summative PT-group. Test preparation, and active feedback use were relatively low and similar in both groups. Both quantitative, and qualitative results showed that the motivation to prepare and consult feedback relates to how students value the assessment. In the interview data, a link could be made with goal orientation theory, as performance-oriented students perceived the formative PT as not important due to the lack of study credits. This led to low test-taking effort, and feedback consultation after the formative PT. In contrast, learning-oriented students valued the formative PT, and used it for self-study or self-assessment to gain feedback. Our results indicate that most students are less motivated to put effort in the test, and use feedback when there are no direct consequences. A supportive assessment environment that emphasizes recognition of the value of formative testing is required to motivate students to use feedback for learning.
Empirical Concepts: Their Meaning and its Emergence
Authors: Radder Hans
Published: March 2024

This article presents a detailed, novel account of the emergence of (the meaning of) empirical concepts. Acquiring experience and empirical concepts is shown to be the result of multifaceted, cognitive processes, which require both material realization and conceptual interpretation. Generally speaking, the meaning of empirical concepts consists of several distinct components, but it includes at least a structuring and an abstracting component. These two meaning components are abstract entities, which can be justifiably interpreted as real objects.

On this basis, I address the subject of emergence. The primary claim is that the abstracting meaning component (but not the structuring one) emerges from its underlying empirical processes: it both depends on and transcends these processes. This claim is expounded by discussing relevant similarities and dissimilarities between the emergence of abstract meanings and a range of central features of emergence prominent in recent debates on this topic. The conception of empirical concepts with emergent abstracting meaning components involves an interpretation that avoids the problematic extremes of both empiricism and Platonism.
The (im)possibility of a term: ‘Pasmanda’, the (non-)addressability of the state, and the ghettoization of communication
Authors: Ohm Britta
Published: March 2024

‘Pasmanda’ is arguably the most explosive term that the more recent anti-caste discourse in India has produced. It is assembled from the Persian words pas (‘back’) and manda (‘left behind’), thus describing somebody ‘at the back’ (of society), who ‘has been left behind’. Like ‘Dalit’, ‘Pasmanda’ is essentially a political term, which means that it only comes into being and develops significance if people decide to acquire it and to identify themselves as different and as discriminated—in this case as lower-caste and ‘Dalit Muslims’. ‘Pasmanda’ is hence intrinsically reliant on being communicated and mediated so as to enable its acceptance among the signified and to normalise the creation of a respective reality through a newly collectivising identity. This essay approaches ‘Pasmanda’ as ‘a term to think with’, in tracing the very possibility, among deprived and discriminated groups, to openly communicate, negotiate, and mediate this identity that challenges claims of religious (comm)unity and demands for national loyalty. This possibility varies greatly even across north India. As I examine ‘Pasmanda’ through three different local prisms, the term thus also becomes a dialectical index for the political conditions of its realisation: the conditions of its emergence and, however increasingly precarious, its thriving (in the state of Bihar) as much as the conditions for its suppression (in the capital Delhi) and even of its complete absence (in the state of Gujarat)—i.e. of the conditions that render Pasmandas non-existent. A different form of regional comparison thus emerges.
Context Matters: Factors that Influence Storytime Providers’ Knowledge, Beliefs, and Self-Efficacy
Authors: Perkins Roseanne M. , Sawyer Brook E.
Published: March 2024

Understanding how to successfully train storytime providers is crucial to the goal of offering high-quality early literacy programs in public library settings. As part of a larger study, nine early-career public library storytime providers were interviewed to learn what contextual factors are important to improve their knowledge, practice, and self-efficacy. Two major themes and several subthemes emerged from this analysis. The first theme centered on how participants learned and developed self-efficacy about early literacy practices. Four subthemes emerged: (a) impact of formal education and training, (b) influence of mentors and role-models, (c) developing practice through experimentation and mastery experiences, and (d) importance of feedback. The second theme centered around how the unique nature of public library storytime programs impacts the practice and self-efficacy of providers. Five subthemes emerged: (a) voluntary nature of storytime programming, (b) balance between education and entertainment, (c) whether the primary audience is children or caregivers, (d) concerns about how caregivers perceive communication, and (e) how the informal, mixed-age audience influences programming. Findings can be used to inform the content of future professional development interventions.
How U.S. Early Childhood Educators Understand Children’s Spirituality: A Framework of Essence, Origin, and Action
Authors: Mata-McMahon Jennifer , Haslip Michael J. , Hossain Shahin
Published: March 2024

This study explores in-service early childhood educators’ understanding of children’s spirituality. Utilizing the recently validated instrument, Early Childhood Educators’ Spiritual Practices in the Classroom (ECE-SPC), responses to the question, “What do you understand children’s spirituality to be?” were analyzed. Participants included 318 educators working in secular educational settings with children ages zero to eight years across 36 U.S. states. Findings reveal a multilayered understanding of children’s spirituality. Through a grounded theory approach to data analysis using in-vivo codes in initial and axial coding, participants’ responses were organized in a response framework comprised of three main categories of understanding spirituality: (1) as Essence in itself (f 208), (2) as its place of Origin (f 122), and (3) as Actions in relation to others or as ways in which it is practiced (f 86). This framework contributes to constructing a shared understanding of children’s spirituality to build efforts toward promoting holistic development and intentionally nurturing the spiritual domain.
Circular Definitions of ‘Good’ and the Good of Circular Definitions
Authors: Garcia Andrés G.
Published: March 2024

I defend the view that circular definitions can be useful and illuminating by focusing on the fitting-attitudes analysis of value. This definition states that an item has value if and only if it is a fitting target of attitudes. Good items are the fitting targets of positive attitudes, and bad items are the fitting targets of negative ones. I shall argue that a circular version of this definition, defended by Rabinowicz and Rønnow-Rasmussen (2006), is preferable to its non-circular counterpart and upholds reasonable standards of acceptability. The standards I will be discussing come from Humberstone (1997), who claims that definitions cannot be informative as long as they are inferentially circular.
Examining the Impact of Dramatization Simulation on Nursing Students’ Ethical Attitudes: A Mixed-Method Study
Authors: Ordu Yadigar , Yılmaz Sakine
Published: March 2024

This research investigated how dramatization simulation affected nursing students' ethical attitudes. Most nurses and nursing students encounter ethical issues in their healthcare practices. Students who receive an education in ethics are better equipped to solve ethical problems, develop ethical sensitivity, and adopt an ethical attitude. Dramatization simulation, which has recently been applied in nursing education, is said to be an effective teaching method. A mixed-method approach was employed in the research. The sample consisted of 60 students enrolled in the final year of the Nursing Department of the Faculty of Health Sciences at a State university. Students were randomly assigned to experimental and control groups. In the experimental group, the dramatization simulation method was used to evaluate the effectiveness of the training method. The data were collected using the Descriptive Characteristics Form, Ethical Principles Attitude Scale, and Semi-Structured Focus Group Interview Form. SPSS 22 software was used to analyze the quantitative data, and Colaizzi's phenomenological analysis and MAXQDA 2020 software were used to analyze the qualitative data. The post-test total score of the group ethical attitude scale for the students in the experimental group showed a statistically significant improvement (p < 0.05). Additionally, the students in the experimental group's post-test Ethical Attitude Scale total score outperformed those in the control group statistically significantly (p < 0.05). The following themes were found: (1) perspectives on dramatization simulation and (2) perspectives on ethical attitude. To help nursing students develop ethical attitudes, we recommend using dramatization simulation as a teaching method. In addition, we recommend that this study be conducted in larger sample groups and on different topics. The recommendations were explored in more detail in the article.
An approach to understand the uranium’s concentration variance on the eastern and western sides of the Nile Valley phosphorites, Egypt
Authors: Negm Sameh H.
Published: March 2024

The Nile Valley is a main area for Egyptian phosphorites. The studied samples from the eastern and western sides of the Nile Valley showed similarities in their characteristics, suggesting one depositional basin, but they varied in their uranium content, with averages recorded at 91.7 and 44.83 ppm on the eastern and western sides, respectively. The evidence pointed out that initially the uranium was formed by adsorption onto the iron oxides and organic matter surfaces, then it was partially removed under the effect of groundwater, and the removal was deeper in the western phosphorites than the eastern ones.
Boundedness and Convergence of Mini-batch Gradient Method with Cyclic Dropconnect and Penalty
Authors: Jing Junling , Jinhang Cai , Zhang Huisheng , Zhang Wenxia
Published: March 2024

Dropout is perhaps the most popular regularization method for deep learning. Due to the stochastic nature of the Dropout mechanism, the convergence analysis of Dropout learning is challenging and the existing convergence results are mainly of probability nature. In this paper, we investigate the deterministic convergence of the mini-batch gradient learning method with Dropconnect and penalty. By drawing and presenting a set of samples of the mask matrix of Dropconnect regularization into the learning process in a cyclic manner, we establish an upper bound of the norm of the weight vector sequence and prove that the gradient of the cost function, the cost function itself, and the weight vector sequence deterministically converge to zero, a constant, and a fixed point respectively. Considering Dropout is mathematically a specific realization of Dropconnect, the established theoretical results in this paper are also valid for Dropout learning. Illustrative simulations on the MNIST dataset are provided to verify the theoretical analysis.
Bioaccessibility and Antioxidant Capacity of Grape Seed and Grape Skin Phenolic Compounds After Simulated In Vitro Gastrointestinal Digestion
Authors: Elejalde Edurne , Villarán María Carmen , Esquivel Argitxu , Alonso Rosa María
Published: March 2024

Grapes present recognized beneficial effects on human health due to their polyphenolic composition. The grape overproduction together with the wine sales down and the world socioeconomic situation makes the wine grape valorization a promising strategy to give an added-value to this natural product. The objective of the present work was to study the influence of in vitro gastrointestinal digestion on antioxidant capacity and polyphenolic profile of skin and seed extracts of different grape varieties (Tempranillo, Graciano, Maturana tinta and Hondarrabi zuri). After in vitro gastrointestinal digestion, total phenolic content (TPC) of seed polyphenolic extracts decreased significantly for all the varieties. The highest decrease was for Tempranillo going from 108 ± 9 to 50 ± 3 mg / g dry matter (dm). This variety also showed the highest decrease of 90% in antioxidant capacity. However, for all the skin polyphenolic extracts there was an increase in TPC. The highest variation was also for Tempranillo. It varied from 10.1 ± 0.8 to 55.1 ± 0.9 mg / g dm. Among red varieties Tempranillo skin polyphenolic extract showed the lowest undigested anthocyanin content but the highest bioaccessibility index (BI) of 77%. For flavanols, flavonols and procyanidins the seed polyphenolic extracts showed a BI at the intestinal phase between 11% for (+)-epicatechin gallate to 130% procyanidin A2. The results of this study suggest that grape skin extracts and grape seed extracts are a reliable source of bioaccessible antioxidant polyphenols, to be used for the development of antioxidant supplements with specific functionalities depending on the grape variety.
Gender Equity in Deanship of the Central and Eastern European Law Schools
Authors: Kużelewska Elżbieta , Kraśnicka Izabela , Gruodytė Edita , Plakolli-Kasumi Luljeta , Trocan Laura Magdalena , Žuber Bruna , Draganov Jivko
Published: March 2024

The paper aims to analyze the scope of female leadership (deanship) at public and non-public law faculties in selected countries from the region of Central and Eastern Europe: Poland, Hungary, Czechia, Slovakia, Lithuania, Latvia, Estonia, Bulgaria, Romania, Slovenia, Croatia, Serbia, Kosovo, Bosnia and Hercegovina, Montenegro. The paper will explore the engagement of women in the administration of law schools operating within public (and non-public) schools (universities) across the region in the latest years. The paper aims to show the number of female deanships at law faculties in the analyzed states. This analysis will be based on statistical data obtained from the available public sources (including national databases as well as the European Union resources) providing the number of female deans and vice-deans appointed or elected by the academia at all higher education institutions within the country. The initial hypothesis states that gender inequality has been present in the deanship of analyzed law schools and reflects general trends in gender equality in Europe. Comprehensive analysis of the central and eastern European states will allow formulating the key conclusions and answering the following research questions concerning the differences in the numbers of women on the key positions within the law faculties in terms of public versus non-public institutions and in the light of the general gender equality trends in the continent. The research methods used for the analysis include a dogmatic method, statistical method as well as comparative method.
The Textual Organisation of CJEU Judgments
Authors: Trklja Aleksandar
Published: March 2024

This research paper focuses on the comprehensive description and analysis of the structure of judgments from the Court of Justice of the European Union (CJEU). Despite the growing interest in examining the rhetorical and linguistic aspects of legal texts, the genre structure of judgments has remained a little-explored area. While headings and paragraph enumeration provide a systematic reference system for citation and cross-referencing they do not reveal the dynamic relations between individual text chunks in judgments. The current analysis combines Swales and Bhatia's genre theory with Hoey's approach to patterning in discourse and corpus linguistics analyses. The findings show that the complexity of CJEU judgments extends beyond surface-level information with linguistic expressions playing a crucial role in highlighting dynamic relations and discourse patterning. The results reveal how the structure of CJEU judgments has changed over time and point to the intratextual relations between different sections. Additionally, the study provides a detailed description of the textual organisation of CJEU judgments in terms of move structures and conventionalised discourse patterns.
Attitude ascriptions: a new old problem for Russell’s theory of descriptions
Authors: Rinner Stefan
Published: March 2024

In order to explain that sentences containing empty definite descriptions are nevertheless true or false, Russell famously analyzes sentences of the form ‘The F is G’ as ‘There is exactly one F and it is G’. Against this it has been objected that Russell’s analysis provides the wrong truth-conditions when it comes to non-doxastic attitude ascriptions. For example, according to Heim, Kripke, and Elbourne (HKE), there are circumstances in which (1) is true and (2) is false.

Hans wants the ghost in his attic to be quiet tonight.

Hans wants there to be exactly one ghost in his attic and for it to be quiet tonight.

After all, the argument goes, unlike (2), (1) can be true without Hans wanting there to be exactly one ghost in his attic. Kaplan and Neale famously reply that the HKE objection presupposes that non-doxastic attitudes are closed under entailment, which they are not. For Rostworowski, on the other hand, the problematic principle used by the HKE objection is a substitutivity principle for non-doxastic attitude ascriptions. This is further supported by the fact that, as Elbourne points out, Russell’s analysis already leads to a problem similar to the HKE objection together with substitutivity alone. By questioning substitutivity for non-doxastic attitude ascriptions, Rostworowski tries to block both the HKE objection and Elbourne’s variant of the HKE objection. In this paper, I will argue that Russell’s analysis of definite descriptions leads to a variant of the HKE objection even in the context of doxastic attitude ascriptions. Since, as we will see, doxastic attitude ascriptions do not seem to suffer from the substitutivity problems discussed by Rostworowski in the context of non-doxastic attitude ascriptions, this will further exacerbate the problem for Russell’s analysis. I will then discuss the possibility to reject substitutivity for doxastic attitude ascriptions using a contextualist analysis of attitude ascriptions. However, we will see that, independent of whether we accept substitutivity for doxastic attitude ascriptions, a complete solution of the doxastic problem has to reject Russell’s analysis of the truth-conditions of sentences of the form ‘The F is G’. Concluding, I will show that, unlike Russell’s analysis, the Frege–Strawson analysis of definite descriptions, according to which a sentence of the form ‘The F is G’ presupposes that there is exactly one F, rather than asserting it, provides an explanation of the HKE objection, Elbourne’s variant of the HKE objection, and the doxastic problem presented in this paper. This will speak not only in favor of a Fregean analysis of definite descriptions, but also of a Fregean conception of propositions.
Stochastic Periodic Microstructures for Multiscale Modelling of Heterogeneous Materials
Authors: Ricketts Evan John
Published: March 2024

Plurigaussian simulation is a method of discrete random field generation that can be used to generate many complex geometries depicting real world structures. Whilst it is commonly applied at larger scales to represent geological phenomena, the highly flexible approach is suitable for generating structures at all scales. Here, an extension of plurigaussian simulation to periodic plurigaussian simulation (P-PGS) is presented, such that the resulting fields are periodic in nature. By using periodic Gaussian random fields as components of the method, periodicity is enforced in the generated structures. To substantiate the use of P-PGS in capturing complex heterogeneities in a physically meaningful way, the pore-scale microstructure of cement paste was represented such that its effective properties can be calculated through a computational homogenisation approach. The finite element method is employed to model the diffusion of heat through the medium under dry and saturated pore conditions, where numerical homogenisation is conducted to calculate the effective thermal conductivity of the medium. Comparison of the calculated values with experimental observations indicated that the generated microstructures are suitable for pore-scale representation, given their close match. A maximal error of 1.38% was observed in relation to the numerically determined effective thermal conductivity of mortar paste with air filled pores, and 0.41% when considering water filled pores. As the assumption of a periodic domain is often an underlying feature of numerical homogenisation, this extension of plurigaussian simulation enables a path for its integration into such computational schemes.

Article Highlights

Integrating P-PGS into numerical homogenisation frameworks enhances complex heterogeneous material representation

The flexibility of P-PGS enables a wide range of material microstructures to be represented accurately

Use of the generated structures allows material properties to be estimated accurately through numerical homogenisation
Insects as potential vectors of phytoplasmas in urban trees in a mega-city: a case study in Bogotá, Colombia
Authors: Silva-Castaño Andres Felipe , Brochero Helena , Franco-Lara Liliana
Published: March 2024

Urban trees offer many ecosystem services which can be affected by pathogens, including phytoplasmas. Phytoplasmas cause regulator growth imbalances in infected plants, which produce deviations from the normal plant architecture, among other symptoms. In Bogotá, Colombia, ‘Candidatus Phytoplasma asteris’ and ‘Candidatus Phytoplasma fraxini’ infect at least 11 species of urban trees, including Andean oak. This tree species is endemic to Colombia and Panama, and it plays an important ecologic role in the Colombian Andes wild forests. In Bogotá, knowledge about the insect vectors associated with the transmission of phytoplasmas to Andean oak is scarce. In this work we sampled the entomofauna of Andean oaks and evaluated the role of Cicadellidae and Psylloidea taxa as potential vectors of phytoplasmas in Bogotá. Insects were captured using direct and indirect sampling methods from Andean oaks at three contrasting sites in Bogotá, and also from neighbouring trees. The insects were identified by morphological and molecular methods and tested for phytoplasmas. In total, 510 Cicadellidae members of 13 taxa and 129 Psylloidea of 8 taxa were captured; richness and abundance depended on the type and sampling site. The most abundant species were Scaphytopius (Convelinus) sp. (Cicadellidae) and Acizzia uncatoides (Psylloidea). Leafhoppers positive for phytoplasmas were Chiasmodolini, Dikrella (Readionia) sp., Empoasca sp. and Scaphytopius sp. taxa. Our results suggest that several potential species of phytoplasmas may be dispersing phytoplasmas to Andean oaks and other urban tree species. It is necessary to conduct transmission tests to evaluate the transmission capacity of the potential vectors.