bluuebunny/crossref_metadata_2025 huggingface dataset:
Agronomic characterization and interaction of genotype by environment of quinoa under conditions of Brazil and Colombia
Authors: Anchico-Jojoa Wilson , Peixoto Jose Ricardo , Oliveira Júnior Antônio A de
Published: November 2023

ABSTRACT Quinoa is a highly adaptable crop due to its considerable genetic variability, making it an important trait for cultivation under different soil and climatic conditions. To achieve crop-wide adaptation, it is essential to identify variability based on morpho-agronomic differences and genotype x environment (GxE) interaction. This study aimed to characterize eight quinoa progenies in Brazil and Colombia. The experiments in Brazil were conducted in an irrigated area of the Fazenda Água Limpa, Universidade de Brasília, at 1,100 m, on two dates: March to July 2018 and May to August 2019. In Colombia, experiments were carried out in Santander de Quilichao and Popayán at 1,100 and 1,800 m, respectively. The treatments consisted of five progenies selected in Brazil, one from Colombia, and two from Ecuador. The experiments followed a complete randomized block design, with eight progenies and four replications. For statistical analysis, the F test was used with p≤0.01 and p≤0.05. Means were grouped by the Scott-Knott test. The AMMI (Additive Main effects and Multiplicative Interaction) analysis was performed, combining analysis of variance and analysis of principal components, to adjust the main effects of genotypes (G) and environments (E) and the GxE interaction. Significant differences were found at p≤0.01 and p≤0.05 for environments, genotypes, and the interaction of GxE. The progenies with wide adaptation to environments were BRX2, BRX5, BRX6 (selected from BRS Syetetuba) and PRIX (selected from Piartal), with average yields above 3,151.95 kg/ha. The genotypes showed differences at the same location in different periods, expressing the need to carry out selection for specific periods and locations. Genotypes BRX5 and BRX6 showed high agronomic potential in all evaluated environments, being promising for future genetic improvement programs.
Percepciones docentes y familiares acerca del rol de los equipos directivos como líderes inclusivos en la Educación Primaria
Authors: González Alfonso Javier García , Gómez-Millán María Rocío Bohórquez
Published: November 2023

Resumen La inclusión escolar es un factor clave para el desarrollo de una Educación de calidad, siendo el liderazgo inclusivo un elemento fundamental para la consecución de ésta. El liderazgo, además, determina el ejercicio real de inclusión en las escuelas. Así, el objetivo principal de este estudio consistió en analizar las percepciones del profesorado y familias de escuelas de Educación primaria sobre el liderazgo inclusivo. Participaron 110 docentes de Educación primaria de centros públicos de Sevilla y 46 familias, cumplimentando las versiones de docentes y familiares del cuestionario LEI-Q. Los resultados mostraron que la percepción de los docentes sobre el centro educativo como comunidad inclusiva no es positiva y la de las familias tampoco, aunque en menor medida. Así, el liderazgo ejercido por los líderes educativos parece no haber conseguido implementar actualmente suficientes medidas para la construcción de escuelas inclusivas.
Retenção escolar: crenças e práticas dos professores e a sua relação com as políticas educativas das escolas
Authors: Santos Natalie Nóbrega , Monteiro Vera
Published: November 2023

Resumo Alguns autores sugerem que as altas taxas de retenção escolar observadas em alguns países se devem à crença nos benefícios desta prática. O presente estudo procurou compreender o efeito moderador que as políticas educativas das escolas sobre a retenção têm na relação entre crenças e práticas de retenção no 2º ano de escolaridade. Uma análise dos documentos orientadores de 66 escolas da Madeira, Portugal, identificou os critérios e requisitos exigidos para a decisão de retenção. Um questionário online recolheu as crenças e práticas de retenção de 300 professores desta Região. Uma análise de perfis latentes identificou cinco grupos de professores organizados num continuum que variava entre uma maior rejeição e uma maior certeza nos benefícios da retenção. Observou-se uma associação entre as crenças e as práticas dos professores apenas nas escolas que não tinham nem critérios nem requisitos definidos para a decisão de retenção. Os resultados sugerem que os professores precisam de informação que oriente a tomada de decisão e que proporcione maior coerência na atuação dos intervenientes.
Determinantes da eficiência nas instituições federais de Educação profissional brasileiras
Authors: Parente Paulo Henrique Nobre
Published: November 2023

Resumo Este estudo tem o objetivo de examinar os efeitos dos fatores determinantes da eficiência na gestão dos recursos públicos aplicados na Rede Federal de Educação Profissional, Científica e Tecnológica do Brasil. A amostra da pesquisa compreende 40 instituições federais, no período entre 2009 e 2019, totalizando 368 observações. A eficiência foi estimada através da análise envoltória de dados. Posteriormente, identificaram-se os fatores que influenciam a eficiência através da análise de regressão. Os resultados mostram que a relação aluno/docente, a retenção escolar, o auxílio financeiro, o sexo e a formação do gestor melhoram a eficiência, enquanto a titulação docente a reduz. As evidências demonstram que os efeitos das variáveis explicativas diferem a partir das regiões nas quais as instituições estão localizadas. As descobertas desse estudo permitem questionar o processo de alocação de recursos públicos e a tomada de decisão dos gestores no intuito de maximizar a eficiência na Educação.
Representações sócio-históricas de uma doença: um estudo sobre cartazes de campanhas para o combate à hanseníase na segunda metade do século XX
Authors: Porto Carla Lisboa , Marques Maria Cristina da C.
Published: November 2023

Resumo Este artigo analisa o uso de fontes iconográficas no contexto das campanhas educativas para o combate à hanseníase numa perspectiva sócio-histórica em quatro momentos: décadas de 1950, 1960, 1980 e 1990. São analisados quatro cartazes para identificar os elementos (textuais, visuais ou gráficos) utilizados para elaborar um discurso sobre a doença e os doentes; suas transformações discursivas e permanências, além de verificar como se tornaram parte de uma narrativa de memória institucional ligada à saúde pública paulista. As fontes estudadas fazem parte da coleção Cartazes de Campanhas de Saúde, cujos itens foram produzidos por diversas instituições ligadas à saúde pública e integram o acervo do Museu de Saúde Pública Emílio Ribas.
Antropoceno, ciências humanas e historiografia
Authors: Lowande Walter Francisco Figueiredo
Published: November 2023

Resumo O artigo mostra, inicialmente, como as discussões sobre o Antropoceno têm se deslocado de maneira cada vez mais significativa para o campo das ciências humanas. Em seguida, tomando como ponto de partida a proposta de que as ciências humanas deveriam contribuir para a compreensão do “metanível consequencial” dos estudos sobre o Antropoceno, discute como alguns trabalhos produzidos nesse campo têm lidado com as relações entre causas, efeitos e consequências diante das condições do novo regime planetário, considerando de maneira especial as discussões sobre a “tecnosfera”. Conclui indicando o potencial das novas perspectivas ontológicas das ciências humanas para a ampliação dos horizontes explicativos e comunicativos da historiografia.
Anthropocene, human sciences and historiography
Authors: Lowande Walter Francisco Figueiredo
Published: November 2023

Abstract The article initially presents an increasingly significant move of discussions about the Anthropocene towards humanities and social sciences. Then, taking as a starting point the proposal that these fields could contribute to the understanding of the “consequential meta-level” of studies on the Anthropocene, it discusses how some works produced in humanities and social sciences have dealt with the relationship between causes, effects and consequences regarding the new planetary regime, with a special focus on the debate about the “technosphere.” It concludes by indicating the potential of the “ontological turn” to expand the explanatory and communicative horizons of historiography.
Influence of exposure Heterorhabditis bacteriophora HP88, (Rhabditida: Heterorhabditidae) on biological and physiological parameters of Pseudosuccinea columella (Basommatophora: Lymnaeidae)
Authors: Sperandio Natânia do Carmo , Tunholi Victor Menezes , Amaral Ludimila Santos , Vidal Maria Larissa Bitencourt , Cassani Lais Sperandio , Tunholi-Alves Vinícius Menezes , Couto-Chambarelli Melissa Carvalho Machado do , Boeloni Jankerle Neves , Monteiro Caio , Martins Isabella Vilhena Freire
Published: November 2023

Abstract Many studies about fasciolosis control have been carried out, whether acting on the adult parasite or in Pseudosuccinea columella, compromising the development of the larval stages. The present study aimed to evaluate, under laboratory conditions, the susceptibility of P. columella to Heterorhabditis bacteriophora HP88, during for 24 and 48 hours of exposure. The snails were evaluated for 21 days for accumulated mortality; number of eggs laid; hatchability rate; biochemical changes; and histopathological analysis. We found that exposure induced a reduction in glucose and glycogen levels, characterizing a negative energy balance, due to the depletion of energy reserves as a result of the direct competition established by the nematode/endosymbiont bacteria complex in such substrates. A mortality rate of 48.25% and 65.52% was observed in the group exposed for 24 h and 48 h, respectively, along with significant impairment of reproductive biology in both exposed groups in relation to the respective controls. The results presented here show that P. columella is susceptible to the nematode H. bacteriophora, with the potential to be used as an alternative bioagent in the control of this mollusk, especially in areas considered endemic for fascioliasis, in line with the position expressed by the World Health Organization Health.
Uncovered interest rate, overshooting, and predictability reversal puzzles in an emerging economy
Authors: Kilic Rehim
Published: November 2023

By using realized and survey-based expected exchange rate data, the paper presents five key findings regarding the Uncovered Interest rate Parity (UIP) and related puzzles in an Emerging Market (EM). First, Fama regressions, when not accounting for shifts in the UIP relationship, yield slopes that are statistically identical to one, irrespective of whether survey-based expected exchange rates or realized exchange rates are used. Second, caution is necessary however, as our analysis identifies three distinct sub-periods within each exchange rate measure, each exhibiting varying levels of puzzling behavior. Third, under realized exchange rates, expectation errors can introduce both downward and upward biases or no bias at all, depending on the sub-period. On the other hand, currency risk premiums consistently lead to a downward bias. Under expected exchange rates, currency risk premiums continue to exert a downward bias at varying degrees across sub-periods. Fourth, responses to interest rate differential shocks by expectation errors are pivotal in inducing both downward and upward biases or removing biases altogether when utilizing realized exchange rate data. Fifth, evidence concerning overshooting and reversal puzzles, as well as their link to the UIP puzzle, varies depending on the specific sub-period and the choice of exchange rate measurement, making it more intricate than the previous literature has documented.
Trade Uncertainty and U.S. Bank Lending
Authors: Correa Ricardo , Giovanni Julian di , Goldberg Linda S. , Minoiu Camelia
Published: November 2023

This paper uses U.S. loan-level credit register data and the 2018–2019 Trade War to test for the effects of international trade uncertainty on domestic credit supply. We exploit cross-sectional heterogeneity in banks’ ex-ante exposure to trade uncertainty and find that an increase in trade uncertainty is associated with a contraction in bank lending to all firms irrespective of the uncertainty that the firms face. This baseline result holds for lending at the intensive and extensive margins. We document two channels underlying the estimated credit supply effect: a wait-and-see channel by which exposed banks assess their borrowers as riskier and reduce the maturity of their loans and a financial frictions channel by which exposed banks facing relatively higher balance sheet constraints contract lending more. The decline in credit supply has real effects: firms that borrow from more exposed banks experience lower debt growth and investment rates. These effects are stronger for firms that are more reliant on bank finance.
CRYPTOCURRENCY IN INSOLVENCY ESTATE
Authors:   Perm State University, Syatchikhin A.V.
Published: November 2023

Abstract:at the beginning of 2018, considerable attention of lawyers attracted the case of a citizen’s bankruptcy with the decision to include cryptocurrency in the bankruptcy estate. This case exposed a number of problems associated with legal uncertainty regarding new technology products. What is cryptocurrency? To what objects of civil rights should it be attributed? What is the foreign practice and has the global tendency of regulating such relations formed? It is these issues that have become key to this article and determine its structure. The history of the issue, which has been going on for more than twenty years, is examined, foreign approaches of the legislator and law enforcer to regulate these relations are examined, the question of the economic nature of cryptocurrency is touched upon and, most importantly, questions are raised that law enforcers and legislators have yet to find answers.
[Errata] Percepção de pais e cuidadores de crianças com deficiência sobre os serviços de reabilitação durante a pandemia da COVID-19 no Brasil
Authors: De Souza Jenifer Silva , Lima Maria Cecília Marconi Pinheiro
Published: November 2023

INTRODUÇÃO: Observou-se durante a pandemia do coronavírus no Brasil a suspensão das sessões de reabilitação de crianças com deficiência. OBJETIVO: Analisar o andamento das sessões de reabilitação durante a pandemia, bem como a forma de suporte que os pais/cuidadores receberam neste período. MATERIAIS E MÉTODOS: Estudo qualitativo, com delineamento transversal, conduzido on-line pela plataforma Survey Monkey. Participaram pais e cuidadores de crianças com deficiência motora de zero a quatro anos de idade, que foram recrutados através das mídias sociais. A coleta de dados ocorreu por um questionário com 17 perguntas abertas e fechadas, acessível por um período de três meses durante o período de novembro de 2020 a janeiro de 2021. RESULTADOS: Todos os questionários foram lidos na íntegra e após observada saturação das respostas, 37 foram elegíveis. A suspensão das sessões nos serviços de reabilitação variou de 2 a 9 meses. Durante este período, vinte e seis famílias receberam orientações do profissional ou da instituição para estimular a criança em casa; para os demais, que não receberam orientações, a justificativa fornecida era que deviam aguardar a retomada dos atendimentos. Dezesseis famílias tiveram dificuldades para realizar as atividades/exercícios propostos pelos profissionais de saúde em ambiente domiciliar. CONCLUSÃO: Foram identificados, através das respostas dos pais, sentimentos de preocupação e ansiedade com a suspensão dos serviços de reabilitação durante a pandemia e medo com os possíveis prejuízos no desenvolvimento neuropsicomotor das crianças. Além disso, os pais se sentiram desamparados pelos serviços de saúde e profissionais.
Süperkapasitör: Temelleri ve malzemeleri
Authors: ÖZADA Çağatay , ÜNAL Merve , YAZICI Murat
Published: November 2023

Enerji depolama sistemleri içinde süperkapasitör çalışmaları son on yıldır önemli derecede artış göstermektedir. Süperkapasitörler, iki elektrot, bir ayırıcı ve bir elektrolit çözeltiden oluşan elektrokimyasal kapasitörlerdir. Süperkapasitör, kapasitör ve Li-ion bataryalardan ayıran en önemli özellikleri yüksek güç yoğunluğuna ve uzun döngü sayılarına sahip olmasıdır. Bu durum süperkapasitörlerin tüketim malzemelerinden (fotoğraf makineleri, bilgisayar donanımları, vb.) savunma sanayinde (lazer silahlarda) kullanılmak üzere geniş bir kullanım alanı sunmaktadır. Bunun yanı sıra kullanım alanları içinde günümüzde giderek gelişmekte olan elektrikli ve hibrit araç teknolojileri de bulunmaktadır. Bu araçlarda süperkapasitörlerin kullanımı bataryaların performansını arttırmaktadır. Bu çalışmada süperkapasitörlerin çalışma prensipleri detaylı olarak incelenmiştir. Bunun yanında süperkapasitör tiplerine göre oluşturulmuş elektrotların (grafen, aktif karbon, karbon nanotüp, metal oksitler, iletken polimerler) güncel elektrokimyasal performans ölçümleri incelenmiştir. Bu makale sayesinde çalışmaların daha üstün performanslı süperkapasitörler ve kullanım alanlarının geliştirilmesine katkı sağlayacağı ortaya konmaktadır.
Model per a desenvolupar l'estratègia digital d'una institució educativa
Authors: Garcia i Grau Francesc , Valls Bautista Cristina
Published: November 2023

Per a millorar la seva cultura digital, una institució educativa ha de disposar d'un Pla d'Estratègia Digital. L'objectiu d'aquesta recerca és presentar un model d'incorporació de la tecnologia digital (TD) a l'aula per a millorar la qualitat formativa d'un centre d'educació bàsica i batxillerat, a partir del desenvolupament en competència digital docent (CDD). El present model, basat en 5 fases, durant les quals s'utilitzen instruments d'avaluació de la CDD i d'anàlisi de la infraestructura, permet afermar l'ús de la TD a l'aula per part dels docents a través d'accions formatives; afavoreix l'establiment d'accions de millora en CDD, a partir dels resultats obtinguts, de la reflexió d'òrgans de coordinació i de la implicació dels directius; i fa possible l'avanç en la maduresa digital de l'organització. La flexibilitat del model permet adaptar-se amb facilitat a les necessitats de qualsevol centre que pretengui millorar digitalment.
Innovations in Journalism as Complex Interplay: Supportive and Obstructive Factors in International Comparison
Authors: Meier Klaus , Graßl Michael , García-Avilés Jose Alberto , Mondejar Dámaso , Kaltenbrunner Andy , Lugschitz Renée , Porlezza Colin , Mazzoni Petra , Wyss Vinzenz , Saner Mirco
Published: November 2023

Where does innovation in journalism come from, how is it implemented, and what factors drive or hinder its development? Scholars have explored these questions from different perspectives for over two decades. Our research holistically considers the broader factors that influence the development of journalistic innovation at the macro, meso, and micro levels, and whether it is internally or externally driven. In a three-year international research project, we have unpacked innovation with this multidimensional approach, looking at the most important innovations in journalism in Austria, Germany, Spain, Switzerland, and the UK. Our study focuses on the mutual interplay between journalists, media organizations, and society. We investigated 100 case studies with 137 guided interviews with senior managers or project leaders. The results show that the focus of supporting and obstructive factors is internal and on the meso level and that many parallels exist between media systems. Internal factors are the intrinsic motivation of individuals, which need the support of open-minded management, allowing a culture of experimentation without economic pressure and assembling interdisciplinary teams. Across countries and independent of the respective media system, three external key drivers of innovation in journalism can be identified: technology, societal change, and change in the digital media universe. The study confirms once again as if through a magnifying glass that journalism is primarily a public service, especially for those innovations that strengthen the role of journalism in a democratic society.
FORMATION OF THE INNOVATIVE COMPONENT OF THE INTERNATIONAL COMPETITIVENESS OF THE WORKFORCE OF UKRAINE IN THE CONDITIONS OF GLOBAL DIGITALIZATION
Authors:   Educational and Scientific Institute of International Relations of Taras Shevchenko National University of Kyiv, Kovbych T.
Published: November 2023

The article is devoted to the consideration of the basic characteristics, the economic focus of the process of formation of the innovative component of the international competitiveness of the workforce of Ukraine in the conditions of global digitalization of the world economy. The innovative component of the international competitiveness of the workforce is defined as the potential professional abilities of employees who are able to optimally use the latest achievements of scientific and technological progress in social production. The main components of the innovative component of the formation of the international competitiveness of the domestic workforce are studied, namely: a) the level of mastery of modern information and communication tools; b) targeting the constant mastery of new digital technologies; c) acquisition of professional competences oriented to the parameters of world standards; d) modernization of the national system of higher education in the direction of training highly qualified specialists in demand on the domestic and global labour markets; e) using the advantages of cooperation with international partners in the field of involvement in training and borrowing new forms and methods of ensuring the professional growth of young specialists. Factors affecting the development of the innovative component of the international competitiveness of national labour resources are analyzed. They include: 1) the consequences of the russian military aggression against Ukraine, which led to a decrease in the national scientific and technical potential; 2) forced migration of specialists within our country and abroad; 3) insufficient development of the IT sector of the domestic labour market; 4) regional disparities in the use of highly qualified labour force; 5) inadequate financing of the system of training of highly qualified personnel. The directions for strengthening the innovative component of the international competitiveness of the domestic workforce are proved, including: a) development of balanced state programs for national and regional development of highly qualified labour resources; b) modernization of higher education standards in the training of specialists of various professions; c) implementation of measures to stimulate the development of the national IT industry, digitization of industries and spheres of domestic production; d) formation of analytical centers for the study of features and trends in the development of world labour markets; e) adoption of an innovative national system of qualifications, oriented to the needs of internal and external business.
MODELLING SUBJECTIVE VIEWS OF INDIVIDUALS ABOUT NATIONAL MACROECONOMIC PERFORMANCE
Authors:   Educational and Scientific Institute of International Relations of Taras Shevchenko National University of Kyiv, Chugaiev O. А.
Published: November 2023

The aim of this paper is to estimate the effect of the main macroeconomic indicators on opinion of individuals about economic situation in their country. Correlation and regression analysis was applied to the data about 43 economies in 2002-2021. The most positive subjective views of economic situation were before crisis years (in 2007 and 2016-2019). This paper confirms positive effect of economic growth on perceived national economic situation. The effect is stronger under high income inequality in the long run and in advanced economies in the short run. Some models suggest that acceleration of economic growth may also be important. Gross savings is another positive factor. The long-term effect of savings is stronger in countries with high income inequality and in 2013-2021 also in advanced economies. Correlation between opinion of people and current account is positive, but the regression analysis results show that this factor does not have a separate significant effect. Unemployment influences perceived national economic situation negatively. But earlier (in 2002-2012) this effect was weaker than in 2013-2021. The long-term effect is stronger in countries with high income inequality. The effect of inflation is negative, but it existed only in the first subperiod (2002-2012) in advanced economies. Then the fear of inflation disappeared at least before 2022, when inflation increased. Income inequality, its change and economic development level do not affect perceived economic situation themselves. But high income inequality increases sensitivity of people to trends in economic growth, unemployment and gross savings. High development level also increases such sensitivity and earlier in XXI century dependence on inflation.
Emerging Biomarkers for Early Detection of Cardiovascular Disease
Authors: Kutagolla Peera  , Anurag Rawat  , Sarath M Nair  , Obaiah Jamakala  , Mohammad Chand Jamali
Published: November 2023

This extensive study explores the field of novel biomarkers for the early detection of cardiovascular disease (CVD), looking at a variety of indicators, including circulating endothelial cells, growth differentiation factor-15 (GDF-15), high-sensitivity C-reactive protein (hs-CRP), microRNAs, and myeloperoxidase (MPO). The review emphasizes how important these indicators are to improving CVD risk assessment, prognosis, and treatment plans. While each biomarker offers distinct insights into particular facets of cardiovascular health, multi-biomarker panel integration is suggested for a more thorough knowledge. The paper also discusses the difficulties with standardization, moral issues, and legal restrictions related to using these biomarkers in therapeutic settings. In addition, the revolutionary potential of these new biomarkers in conjunction with state-of-the-art technologies is emphasized, providing a promising path towards precision cardiovascular care and customized medicine
The Theoretical Description for Fructose Fermentation Product Hydroxyquinol and its Ether Sesamol Amperometric Determination in Tahini Halva and Lokum
Authors: Volodymyr Tkach  , Kushnir Marta , Korniienko Iryna , Larysa Yastremska , Kuznetsova Olena , Kryvetskyi Viktor , Kryvetska Inna , Kryvetskyi Igor , Yagodynets Petro , Kormosh Zholt , Fedorova Dina , Chikun Nadiia
Published: November 2023

For the first time, hydroxyquinol and sesamol electrochemical amperometric determination in tahini halva and lokum Turkish delights has been described. The electroanalytical process is given by amavadin-modified conducting polymer, in which both monomer and dopant may be natural compounds. Taking into account the ionic nature of the modifier, even in neutral medium the oscillatory behavior will be more probable in this system than in the simplest cases. Nevertheless, the amavadin-modified conducting polymer may be efficient electrode modifier for hydroxyquinol and sesamol electrochemical determination in Turkish delights like lokum and tahini halva.
Death following COVID-19 vaccination: A case report
Authors: Hosahally Jayanth S , Patil Varsha , Chandra Girish Y.P.
Published: November 2023

Vaccines are necessary to reduce the mortality and morbidity of infectious diseases. It has played a vital role in the ongoing coronavirus disease 2019 (COVID-19) pandemic. Different types of vaccines have been developed to combat the pandemic. Adverse events following immunization including anaphylaxis have been reported for all types of COVID-19 vaccine. Anaphylaxis is common in a person who has a history of allergic reactions. Adverse reactions develop within minutes or a few hours after vaccination. Thus, in India, vaccine recipients are made to stay in the medical facility for 30 min for observation.
Herein, we report the case of a 23-year-old woman who succumbed after 24 hours of taking COVISHIELD ChAdOx1 nCoV-19 Corona Virus Vaccine (recombinant). She did not have any symptoms after vaccination during her observation at the medical facility and did not have a history of allergic reactions. She was brought dead to M.S. Ramaiah Hospital, and the autopsy revealed pulmonary edema. Antibodies to COVID-19, inflammatory markers, serum IgE, and coagulation indicators in the postmortem blood sample were high. The cause of death was attributed to a delayed allergic reaction to COVISHIELD vaccine. Newer vaccines can cause fatal allergic reaction, sometimes later than expected, even when cutaneous reactions may not be present.
Bridging the gap: Assessing death certification competency in Bulgarian healthcare education
Authors: Kolev Yanko G. , Valentinova Tsvetelina , Stefanovski Petko H. , Tumbeva Elka , Mirochnik Nikolay M. , Kolev Preslav-Geo Y.
Published: November 2023

BACKGROUND: In Bulgaria, procedural protocols following a citizen’s death are governed by an intricate network of normative documents. Despite the presumed alignment between international and national guidelines, practical experiences reveal shortcomings in the proficiency of healthcare providers, particularly in cases involving prior medical interventions or systemic vulnerabilities.
AIM: This study aimed to assess the readiness of final-year medical students and early-career physicians in navigating death certification intricacies, including their responses, documentation precision, and postmortem procedures for bereaved families, with implications for national health statistics.
MATERIALS AND METHODS: By employing a mixed-methods approach, this study distributed questionnaires to sixth-year medical students and practicing physicians, including those in emergency medicine centers and general practice. Data collection included paper-based and digital questionnaires, ensuring anonymity and ethical compliance. Statistical analysis, employing parametric (t-test) and nonparametric (Chi-square) tests, forms the basis for actionable recommendations and educational material development.
RESULTS: This study included 143 participants, of which 41% expressed apprehension about managing out-of-hospital deaths. Approximately 44% claimed familiarity with death certification regulations, with students displaying higher theoretical confidence but lacking practical knowledge. Remarkably, 74% of physicians never received formal training in death certification. Discrepancies in issuing death certificates, timing, and notification procedures were identified.
CONCLUSION: Findings reveal varying practices among physicians according to their specialties. Issues related to documentation, timing, and notification were prevalent. The study emphasizes the need for improved training, particularly for medical students. Emergency medicine doctors exhibited higher preparedness levels. Medical students and early-career physicians urgently require enhanced education in death certification preparedness. Incorporating these topics into medical curricula, offering specialized courses, and disseminating instructional materials can significantly enhance effectiveness. Future studies should assess the quality and accuracy of recorded causes of death, which affect healthcare statistics, public service, and legal procedures, underscoring the societal and administrative significance of death certification practices.
Source Scaling of Simulated Dynamic Ruptures Using Hierarchical Slip-Weakening Patch Model
Authors: Goto Hiroyuki
Published: November 2023

In seismic hazard assessment, generating a source rupture process consistent with the physics of natural earthquakes is an important issue. This study focuses on the source model with hierarchical patches of slip-weakening distance Dc proposed by Ide and Aochi (2005), which can satisfy the Gutenberg–Richter law. To investigate how the model works, characteristics of the simulated dynamic rupture process in a homogeneous full-space medium and for a vertical strike-slip fault in a half-space medium with a seismogenic zone are analyzed, considering varying dynamic rupture parameters. The source spectrum of the simulated rupture process using the hierarchical patch model generally follows the Brune model. However, the source spectrum underestimates the Brune model near the corner frequencies when the event size grows over Mw 5.5. This spectral shape is consistent with the JA19_2 model (Ji and Archuleta, 2021) of the double-corner-frequency source spectrum. The obtained relationship between the simulated rupture length and magnitude is consistent with the empirical model of Leonard (2010). It confirms that if the event ruptures over the whole seismogenic zone width, the rupture length does not scale linearly with the rupture width, indicating that the seismogenic zone contributes to the relationship between rupture length and magnitude.
An Examination of Teacher Inter-District Migration
Authors:   , Kania Catherine , Vaidya Sheila R.
Published: November 2023

This quantitative non-experimental cross-sectional study aimed to determine the cause(s) of teachers exiting their current employment to migrate to neighboring districts. To predict and alleviate the burden that the loss of experienced teachers imposes, the study examined teachers' intent to migrate by surveying teachers currently working in a large, diverse school district in Southeastern Pennsylvania. By studying the current teaching population, the responses will help to better understand the origin of teacher discontent and subsequent resolve to exit, thus, allowing administrators to implement effective retention policies. Teachers' intent to migrate was studied in the context of organizational commitment, trust, school environment, and self-efficacy. Study findings are expected to help create school plans for stronger teacher commitment and higher retention. Keywords: teacher migration intent, teacher turnover, teacher retention
New Student Affairs Professional Staff Attrition
Authors:   , Lamar Ebonish , Phillips Joy C.
Published: November 2023

This narrative study examined the reasons contributing to new student affairs professional staff attrition of those formerly in live-in positions in residential life departments within higher education institutions across the country. Colleges and universities hire talented professionals to facilitate socialization and campus support experience for undergraduate and graduate student populations. Previous attrition research studies focus on the desire to leave and/or depart across multiple functional student affairs units. This research examined the short employment experiences of the newest live-in professionals within student affairs residential life departments. This research provides an in-depth look into the first five years of former student affairs professionals that led to their field departure. The overarching research question that guided this study was: Why are new student affairs professional staff in live-in positions exiting the field within the first five years of their career? Sub questions that further guided the investigation of this research include: 1) How do former live-in student affairs professionals narrate the factors contributing to their decisions to leave their positions? 2) How do former live-in student affairs professionals narrate their initial perceptions of a career in student affairs? 3) How do former live-in student affairs professionals narrate their experiences of the work environment that contributed to their departure from the field? This narrative study involved five participants and was conducted through semi-structured interviews and journaling. The conceptual framework that informed the current study included three streams of research, history, and practice: student affairs graduate programs, needs of student affairs professionals, and year one on the job. Four key findings emerged from this narrative study: Misrepresentation of student affairs, the reality of student affairs, work-life misalignment, and no future in student affairs. These findings contribute to a better understanding of the experiences of the newest professionals in student affairs residential life departments. The findings offer implications for student affairs residential life departments, student affairs graduate programs, and national associations.
Defining the signaling mechanisms through which dopamine stimulates Akt activation in primary human macrophages
Authors:   , Robinson Dayna , Gaskill Peter J
Published: November 2023

Macrophages are innate immune cells that regulate a variety of essential processes in the immune response. We and others have connected several of the pathways underlying these processes to dopamine receptor activation, demonstrating that dopamine drives inflammation in primary human monocyte derived macrophages (hMDMs). Prior data from our lab have shown that exposure of hMDM to elevated dopamine levels increases the activation of the transcription factor NF-[kappa]B and the production of inflammatory cytokines such as IL-6 and IL-1[beta]. The signaling mechanisms underlying these effects are not clear, although our data have previously shown that dopamine does activate canonical cAMP signaling in human macrophages. To examine whether these effects are mediated by dopamine driven Akt signaling, we treated hMDMs with either dopamine or dopamine receptor agonists or antagonists and evaluated changes in Akt phosphorylation by Western blot. Akt activation requires phosphorylation at both serine 473 and threonine 308, and our data show that dopamine significantly increases phosphorylation at both sites. Phosphorylation was also induced by the D1-like receptor agonists SKF 38389 and A68930, but not the D2-like receptor agonist Quinpirole. To further define the pathway by which dopamine receptors act on Akt, we used the phosphoinositide kinase 3 (PI3K) inhibitor, Buparlisib (BKM 120) and the protein phosphatase 2A (PP2A) inhibitor, okadaic acid (OA). BKM 120 eliminated the capacity of dopamine to phosphorylate Akt, but dopamine had no effect on OA mediated changes in Akt phosphorylation. This suggests that dopamine may act on Akt via activation of D1-like dopamine receptors that stimulate PI3K signaling. However, additional treatments with dopamine or A68930 in the presence of the pan-dopamine antagonist Flupenthixol show that dopamine can also increase Akt phosphorylation when dopamine receptors are blocked. This suggests that dopamine could act on Akt through both dopamine receptor dependent and independent pathways, such as adrenergic receptor activation. Future studies using receptor agonists and antagonists for dopamine and adrenergic receptors will further define and verify these processes. These data add clarity to the mechanisms by which dopamine drives macrophage immune function, potentially enabling the manipulation of dopamine-driven inflammatory activity.
Может ли организм излечить себя от рака? Основные звенья иммунной системы и их роль в противоопухолевой защите
Authors: Заботина Т. Н. , Черткова А. И. , Борунова А. А. , Шоуа И. Б. , Кадагидзе З. Г.
Published: November 2023

Иммунная система является одной из основных систем гомеостаза. Только иммунная система способна отличать «свое» от «чужого» и обеспечивать защиту организма от чужеродных агентов, включая патогенные микроорганизмы и клетки злокачественных опухолей. На существование эндогенного контроля роста опухолей указывают и случаи спонтанной регрессии опухолей. Спонтанная регрессия рака определяется как полное или частичное исчезновение злокачественнойопухоли при отсутствии терапии, способной вызвать противоопухолевый эффект, однако современные подходы к лечению сократили частоту спонтанных регрессий. Иммунное микроокружение опухоли представлено как клетками миелоидного ряда, так и клетками лимфоидного происхождения. Важно отметить фенотипическую и функциональную гетерогенность каждой из этих групп клеток, опосредующих реализацию как эффекторных, так и регуляторных функций. Среди других критических факторов, влияющих на способность различных звеньев клеток осуществлять иммунные реакции, следует отметить их степень и характер инфильтрации в опухоли. Тем не менее, основными иммунокомпетентными клетками являются лимфоциты, способные для решения конкретных задач рекрутировать любые лейкоциты крови. Именно лимфоциты обладают способностью распознавать и запоминать информацию, т. е. обладают иммунологической памятью. Иммунная система подавляет развитие злокачественных опухолей, используя различные механизмы: ликвидацию или подавление вирусной инфекции, что защищает организм от вирус-индуцированных опухолей; своевременную элиминацию патогенов и предотвращение образования воспалительного очага, способствующего развитию опухоли; специфическое распознавание опухолевых (ОСА, ОАА, ОФА) антигенов и элиминацию опухолевых клеток.

   Заключение: Так может ли организм излечить себя от рака? На наш взгляд, может. Об этом свидетельствуют многочисленные факты, описанные в научной медицинской литературе. Однако механизмы данного феномена окончательно не ясны. Очевидным является тот факт, что иммунная система причастна как к возникновению рака, так и к его уничтожению.
Транскриптомный RNA-SEQ анализ опухолевого микроокружения: на пути к разработке молекулярной классификации вирус-ассоциированного плоскоклеточного рака шейки матки
Authors: Курмышкина О. В. , Ковчур П. И. , Волкова Т. О.
Published: November 2023

Молекулярно-генетическое и иммунное разнообразие вирус-ассоциированного рака шейки матки представляет сравнительно малоисследованную проблему, в связи с чем вопрос о существовании разных молекулярных типов и возможности разработки молекулярной классификации пока остается открытым. Вклад иммунного и стромального компонентов опухолевого микроокружения в формирование специфического молекулярного фенотипа также не является в достаточной мере охарактеризованным, в особенности для наиболее ранних стадий прогрессии рака шейки матки. Анализ транскриптома как одной из составляющих молекулярного «портрета» опухоли с помощью технологий секвенирования нового поколения (Next Generation Sequencing, NGS) предоставляет основу для идентификации различных молекулярных типов с перспективой разработки классификации. Генетическое и фенотипическое, в том числе иммунологическое, разнообразие рака шейки матки позволит понять причины различий в агрессивности опухоли, прогнозе, эффективности терапии, а также расширить возможности применения иммунотерапии и комбинированных методов лечения. В данной статье приводится обзор международных и собственных исследований, проводимых в направлении обозначенных проблем.
Состояние онкологической помощи в России: эпидемиология и выживаемость больных злокачественными новообразованиями (однолетняя и пятилетняя) по всем локализациям опухолей. Влияние пандемии коронавируса (популяционное исследование)
Authors: Мерабишвили В. М.
Published: November 2023

Эпидемиологические исследования динамики заболеваемости и смертности населения от ЗНО в нашей стране и в мире активно проводятся с 60-х годов XX столетия, параллельно шло формирование методологии учета, накопления и анализа данных, создание комплекса классификаторов. Построение динамических рядов распространенности ЗНО в России и за рубежом возможно только с 70-х годов XX века, до этого шла отработка методологии. На оценку риска возникновения ЗНО оказывают огромное влияние различие возрастного состава сравниваемых групп населения, неблагоприятные условия окружающей, производственной и экологической среды и другие факторы. Созданный в феврале 2019 года ПРР СЗФО РФ объемом более 1,5 млн. наблюдений, охвативший 13,9 млн. населения (больше чем население Белоруссии, Латвии и Эстонии вместе взятых), позволил нам изучить распространенность ЗНО и эффективность лечения больных не только по основным, но и по редким локализациям ЗНО (таким как сердце, вилочковая железа, глаз, молочная железа у мужчин, рак тонкой кишки и др.). Вспышка пандемии в декабре 2019 года, вызванная седьмым, вновь обнаруженным вирусом SARS-CoV-2-бетакоронавирус, очень быстро охватила все континенты. На первом этапе пандемии наблюдалась паника, закрывались амбулаторно-поликлинические учреждения и даже специализированные стационары. Особое внимание нами обращено на изучение закономерностей локализационной структуры заболеваемости ЗНО мужского и женского населения России, включая расчеты повозрастных показателей наблюдаемой и относительной однолетней и пятилетней выживаемости больных ЗНО на основе созданной базы данных популяционного ракового регистра на уровне федерального округа.
Determinants of Restaurant Love: Mediating Role of Restaurant Trust
Authors: Tahir M Mansha
Published: November 2023

This research paper examines the influences of restaurant reputation, restaurant experience, and restaurant trust on restaurant love where restaurant trust is used as mediator. Majority (53%) of the 365 respondents were male. Respondents’ data were collected with closed-end questionnaire and random sampling technique was followed while selecting the respondents. The researcher used SPSS and AMOS to analyze the collected data. The data analysis shows that restaurant reputation and restaurant experience positively influence the restaurant trust and restaurant love and trust mediates between the relationships of reputation and love as well as between the relationship of experience and restaurant love. This research has, implications, limitations, discussed in the last section.
Student-Led Initiatives for cultural heritage awareness: The case of “Meshkat”, Jordan
Authors: Al Tamimi Waed , W. Fareed Mohamed , Jamhawi Monther
Published: November 2023

Jordan's rich cultural heritage, including its historical landmarks, architecture, and traditional crafts, is a source of pride for its people. However, the lack of systematic awareness and consciousness puts it at risk of being lost or forgotten. Many activities and campaigns had been conducted but they were scattered and unorganized. On the other hand, there were some student- led initiatives that played a promising try in promoting cultural heritage and in raising awareness. This study aims to explore the role of student-led initiatives in raising awareness of cultural heritage, using the case of “Meshkat”, a student-based initiative conducted at the University of Jordan. The study employed a qualitative research approach, and data were collected through interviews, discussions, and observation of Meshkat's activities. The results indicate that this initiative provides an effective platform for students to engage in volunteer work and gain practical experience. Additionally, student-led initiatives offer an opportunity for collaboration between students, local communities, and experts in cultural heritage preservation. Therefore, this study recommends promoting and supporting similar initiatives in other communities.
REGIONAL FOREST HEALTH MONITORING PROGRAM: 2022 Report
Authors: Porter Ben , Sirch Matthias , Menzies Hanson , Voorhis Nancy , Wolf Alexana , Schuett Elissa , Pontius Jennifer , Donisvitch Soren , Adams Alison
Published: November 2023

Regional Forest Health Monitoring Program: 2022 Report
Single-phase and two-phase models of a hybrid nanofluid traveling through a non-uniformly heated (PTC) receiver: A comparative study
Authors: BENABDERRAHMANE Amina , HUSSEIN Ahmed Kadhim , YOUNIS Obai , BENAZZA Abdelylah
Published: November 2023

The current study used single and two-phase modeling to numerically explore three-dimen-sional the turbulent forced convection of a hybrid nanofluid passing through a non-uniformly heated parabolic trough solar collector (PTC) for increasing heat transfer. The typical heat flux profile on the receiver’s absorber outer wall was addressed by a finite volume method (FVM) and the MCRT method. The results demonstrated that the single and two-phase models pro-duced almost similar hydrodynamic results but dissimilar thermal ones. It was found that the results of mixture model matched the experimental ones. The results also illustrated that the hybrid nanofluid gives the highest thermal performance for a mixture composed of 1.5% copper + 0.5% alumina dispersed in the water.