bluuebunny/crossref_metadata_2025 huggingface dataset:
A Three-dimensional Ferric Molybdenum(V) Phosphate Network with Tunnels: Synthesis, Structure, Magnetic and Electrochemical Properties
Authors: Yu Kai , Zhou Bai-bin , Yu Yang , Su Zhan-hua
Published: February 2015

A reduced ferric molybdophosphate, (H2en)3(Hen)[FeIII
3 MoV
12O24(OH)8(HPO4)4(PO4)4] ·3H2O (1) has been hydrothermally synthesized and characterized. In compound 1, a sandwich-shaped cluster [Fe(Mo6P4)2] is connected to eight peripheral {FeO5(OH)} octahedra through its eight {PO4} tetrahedra to form a three-dimensional framework with channels which are filled by water and protonated ethylenediamine molecules. The compound exhibits a 4,8-connected 3-D network with a (41261284)(46)2 topology. The DC susceptibility measurement has shown an antiferromagnetic character of the exchange interactions. Additionally, the electrochemical properties of 1-CPE were studied in detail
Unusual Formation of Two New Titanium(IV) Tetraphenolates
Authors: Knizek Jörg , Nöth Heinrich
Published: February 2015

When the product of the reaction of 2,6-di-tert.-butylphenol with TiCl4 in a 3:1 ratio is treated with Na[HBEt3], the isolated product is not (2,6-tert.-Bu2C6H3O)3Ti(HBEt3) but the isomerized ester (2,4-tert.-Bu2C6H3O)4Ti with molecular S4 symmetry. This rearrangement of the R substituents does not occur upon reacting 2,6-diisopropylphenol with TiCl4 and Na[HBEt3]. An unexpected result is also observed for the product of the reaction of tris(2,6-diisopropylphenolato)titanium(IV) chloride with lithium bis(pentafluorophenolato)dihydridoborate. The isolated product proved to be dimeric tris(pentafluorophenolato)(2,6-diisopropylphenolato)titanium(IV) with two bridging pentafluorophenolato groups generating pentacoordinated Ti atoms
A DFT Analysis of the Molecular Structures and Vibrational Spectra of Diphenylsulfone and 4,4'-Sulfonyldianiline (Dapsone)
Authors: Förner Wolfgang , Badawi Hassan M.
Published: February 2015

We have performed density functional calculations with the B3LYP functional and a 6-311G** basis set to obtain the vibrational spectra in harmonic approximation of the anti-leprosy drug Dapsone and the parent compound diphenylsulfone. Although the chemical difference between the two molecules is not that pronounced (Dapsone has amino groups in the para positions in the phenyl rings), Dapsone is an active drug, while to our knowledge diphenylsulfone shows no medical activity. We compared the theoretical results to experimental vibrational spectra found in the literature. With the help of the program GAUSSVIEW we were able to assign the experimentally found spectral lines to specific atomic motions. The remarkable difference between the two molecules, regarding their structural behavior, is that the drug Dapsone has a more flexible structure of the phenyl ring than the parent molecule has. This might contribute to a greater ability of the drug to fit into receptor sites in a cell membrane although one has to be well aware that this plays most propably only a minor role in the drug activity of Dapsone
Guanidinium-tagged Organocatalysts for Direct Aldol Reactions
Authors: Shah Jabbar , Liebscher Jürgen
Published: February 2015

Hexasubstituted guanidinium moieties have been used as ionic liquid tags for organocatalyts for the first time. Such conjugates were obtained in the (S)-proline and (S)-pyrrolidine-2-ylmethyl series by alkylation reactions of pentasubstituted guanidines. The resulting guanidinium-tagged organocatalysts were applied to asymmetric direct aldol reactions providing high stereoselectivities and yields and good recyclability, and thus performed better than (S)-proline itself
Hydrothermal Synthesis and Crystal Structure of a Novel Pb(II) Coordination Polymer
Authors: Wang Xiu-Yan , Ma Shuai , Li Ting , Weng Ng Seik
Published: February 2015

The novel coordination polymer, [Pb(1,4-chdc)(L)], 1, (1,4-H2chdc = cyclohexane-1,4-dicarboxylic acid and L = 11-fluoro-dipyrido[3,2-a:2' ,3'-c]phenazine), has been synthesized using a hydrothermal method and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Crystal data: C26H19FN4O4Pb, triclinic, space group P1, a = 9.074(5), b = 9.499(5), c = 13.853(5) Å , α = 85.640(5), β = 76.127(5), γ = 74.730(5)°, V = 1118.2(9)°A3, Z = 2. The 1,4-chdc ligands link the Pb(II) atoms to form a 1D chain structure. The L ligands are attached on both sides of the chains. Further, π-π interactions among neighboring chains lead to a two-dimensional supramolecular layer
Ligand-controlled Assembly of Cd(II) Metal-Organic Coordination Polymers Based on 3,5-Dinitrobenzoate and Flexible Bis(imidazole) Derivatives
Authors: Liu Guo-Cheng , Zhang Jin-Xia , Wang Xiu-Li , Lin Hong-Yan , Tian Ai-Xiang , Wang Yu-Fei
Published: February 2015

Three new Cd(II) metal-organic coordination polymers, [Cd(bbi)(DNBA)2] (1), [Cd(bbbi)- (DNBA)2] (2), and [Cd(dmbbbi)(DNBA)Cl]·0.38H2O (3) [HDNBA = 3,5-dinitrobenzoic acid, bbi = 1,1-(1,4-butanediyl)bis(imidazole), bbbi = 1,1-(1,4-butanediyl)bis(benzimidazole), and dmbbbi = 1,1-(1,4-butanediyl)bis(5,6-dimethylbenzimidazole)], have been obtained from hydrothermal reactions of cadmium(II) chloride with the mixed ligands HDNBA and the three structurally related flexible bis(imidazole) derivatives. Single-crystal X-ray diffraction analyses have revealed that the dinuclear cadmium clusters acting as nodes interlinked by two μ2-carboxylic groups, are connected to four other clusters through bridging bbi (for 1) and bbbi (for 2) units to generate two extended two-dimensional (2-D) networks. Compound 3 features a 1-D zigzag chain structure. A systematic structural comparison of the title compounds indicates that the conformations and the steric hindrance of flexible bis(imidazole) derivatives each play an important role in the formation of the Cd(II) coordination polymers. The thermal stability of 1 and 2, and the luminescence behavior of 3 were also investigated.
Präparation und Charakterisierung von SiO2-geträgerten Zirconiumoxidnitriden mit hoher Oberfläche und Untersuchung ihrer katalytischen Aktivität bei der Ammoniakzersetzung / Synthesis, Characterization, and Catalytic Activity of Zirconium Oxide Nitrides Supported on High-surface SiO2
Authors: Frenzel Nancy , Otremba Torsten , Schomäcker Reinhard , Ressler Thorsten , Lerch Martin
Published: February 2015

Zirconium oxide nitrides are active ammonia decomposition catalysts for the production of hydrogen. We present a route to zirconium oxide nitrides with high surface area. The precursor used consisted of a high-surface-area silica material coated with zirconium alkoxide. Subsequent hydrolysis and calcination resulted in ZrO2 supported on SiO2. The high surface area of the material could be maintained in the following ammonolysis procedure leading to the corresponding zirconium oxide nitride. In contrast to the as-prepared ZrO2, the zirconium oxide nitrides exhibited a significant catalytic activity in ammonia decomposition, but compared to an iron oxide-based reference material, the new oxide nitrides showed a rather low activity. Nevertheless, zirconium oxide nitrides constitute suitable model systems for elucidating the effect of nitrogen in the anion substructure on the activity and selectivity of oxide-based ammonia decomposition catalysts.
Oxidfluoridsulfide der Lanthanoide vom Formeltyp M3OF5S (M = Nd, Sm, Gd–Ho) / Oxide Fluoride Sulfides of the Lanthanoids with the Formula M3OF5S (M = Nd, Sm, Gd–Ho)
Authors: Grossholz Hagen , Janka Oliver , Schleid Thomas
Published: February 2015

First attempts to synthesize a lanthanoid(III) oxide fluoride sulfide were successful by reacting DyF3 and Dy2O3 with dysprosium and sulfur in a 2 : 5 : 1 : 3 molar ratio at 850 ◦C in tightly sealed tantalum ampoules. In analogy to the dysprosium compound Dy3OF5S, the other representatives of the M3OF5S series with M = Nd, Sm, Gd-Ho could be prepared as well. Almost phase-pure samples were obtained under similar flux-assisted (NaCl) conditions according to 2M +5MF3 +M2O3 + 3S →3M3OF5S. In the hexagonal crystal structure (space group: P63/m; a ≈ 961 - 939 pm, c ≈ 378 - 367 pm; c/a≈0.39,Vm ≈91 - 84 cm3 mol−1, Z = 2), the M3+ cations reside in ninefold anionic coordination realized as tricapped trigonal prisms formed by seven light (O2−/F−) and two heavier S2− anions. One light-anion position exhibits the exclusive character of F− in trigonal non-planar coordination (CN = 3), while the other position with a tetrahedral cationic environment (CN = 4) is mixed occupied by F− and O2− in a 2 : 1 ratio. The S2− anions are coordinated in a trigonal prismatic way by six M3+ cations. From the data of single-crystal X-ray structure analyses, no indication of any ordering for the O2− and F− anions could be obtained, but bond-valence and MAPLE calculations confirmed the results of electron-beam microanalyses carried out earlier to reveal ordered models for Dy3OF5S.
AgScO2 Revisited: Synthesis, Crystal Structure Refinement and Properties of the Single-phase 3R Polymorph
Authors: Dietrich Volker , Jansen Martin
Published: February 2015

Silver scandium oxide AgScO2 has been obtained from Ag2O and Sc2O3 by solid-state reaction at elevated temperature and under high oxygen pressure in stainless-steel autoclaves. AgScO2 was obtained in the 3R Delafossite-type structure, R¯3m, with a = 3.21092(2), c = 18.5398(1) Å and Z = 3, containing virtually no admixtures of the 2H polytype. The fully ordered structure was solved by high-resolution X-ray powder diffraction data, R(F2) = 0.0436, 30 parameters. AgScO2 decomposes at around 740 ºC into Ag and Sc2O3 with the release of oxygen. The conductivity of AgScO2 increases gradually with temperature from 5.79 × 10−18 to 7.94 × 10−10 S cm−1, and is ionic in nature, the activation energy for ion conduction being 75 kJ mol−1 in the temperature range from 250 to 425 ºC.
Syntheses and Crystal Structures of Ruthenium-Salen Complexes Containing Triphenylphosphine Ligands
Authors: Li Yan , Ma Qing , Shi Hua-Tian , Chen Qun , Zhang Qian-Feng
Published: February 2015

Treatment of [Ru(PPh3)3Cl2] with the Schiff base ligand H2salen in THF at reflux afforded a neutral RuIIIsalen complex [RuIII(salen)(PPh3)Cl] (1). Interaction of [RuHCl(CO)(PPh3)3] with H2salen under similar conditions gave a neutral RuII-salen complex [RuII(salen- NH)(PPh3)(CO)] (2). In its formation one of the imine bonds was nucleophilically attacked by hydride to give a mixed imine-amine ligand. The two complexes have been spectroscopically characterized, and the crystal structures of 1 · 2CH2Cl2 and 2 · CH2Cl2 have been established by X-ray crystallography.
Synthesis and Characterization of a New Infinite 1D Polyoxomolybdate Polymer Further Connected via Cu(I) Nicotinate Subunits
Authors: Gschwind Fabienne , Jansen Martin
Published: February 2015

Single crystals of Cu(C6H4NO2)(C6H5NO2)(H2O)2[Mo2O6]n were grown hydrothermally and characterized by X-ray diffraction and elemental analysis. This compound shows a new 1
∞{Mo2O8}4− infinite polymer chain, which is connected via copper(I) nicotinate subunits, forming an overall 3D network
Solvothermal Syntheses and Crystal Structures of Two Thioarsenate Metal Complexes [Co(dien)2]3[As3S6]2 and [Mn(teta)]2As2S5
Authors: Liu Xing , Zhou Jian
Published: February 2015

Two thioarsenates [Co(dien)2]3[As3S6]2 (1, dien = diethylenetriamine) and [Mn(teta)]2As2S5 (2, teta = triethylenetetramine) have been solvothermally synthesized and structurally characterized. 1 consists of isolated cyclic [As3S6]3− anions in a chair-conformation and two different isomeric [Co(dien)2]2+ cations, while 2 consists of neutral [Mn(teta)]2As2S5 moieties built up from saddlelike As2S5 anions as a tetradentate ligand connecting two [Mn(teta)]2+ groups via terminal S atoms. The optical absorption spectrum of 1 is described.
Synthesis, Structures and Reactions of Trimethyltantalum(V) Bis[tri(tert.-butyl)silanolate]
Authors: Knizek Jörg , Nöth Heinrich
Published: February 2015

Bis[tri(tert.-butyl)silanolato]tantalum(V) trichloride reacts with LiMe to give trimethyl-bis[tri- (tert.-butyl)silanolato]tantalum(V), 6. Its molecular structure shows a trigonal-bipyramidal coordination of the Ta atom with the Me groups in the equatorial plane. Its reaction with catecholborane produces preferably B-methyl-catecholborane besides some phenylene-1,2-dioxo-bis(1,3,2-dioxaborolane), 9, and H3 B・ THF. Similarly, the reaction of 6 with dimeric 9-borabicyclononane (9-BBN) generates preferable tri(tert.-butyl)siloxy-9-BBN (75%) and Me-9-BBN (25%). In contrast, cleavage of the Ta-O bonds is the preferred route in the treatment of 6 with H3B ・ THF. 11B NMR shows the formation of (tBu3SiO)2BH and (tBu3SiO)3B or (tBuSiO)3B3O3. No tantalum hydride could be isolated.
Mössbauer Spectroscopic Investigation of the Cesium Suboxoferrate(III) Cs9FeO4
Authors: Hoch Constantin , Schellenberg Inga , Pöttgen Rainer
Published: February 2015

57Fe Mössbauer spectroscopic studies have shown that in cesium suboxoferrate, Cs9FeO4, the iron atom has the formal oxidation state +III. The isomer shift δ = 0.10(1) is in very good agreement with that of a large number of ionic ferrates(III). The same holds for geometrical details of the [FeO4]5− anion, which shows only a small deviation from ideal tetrahedral symmetry giving rise to a quadrupole splitting of ΔEQ = 0.36(2) mm/s
Hydrothermal Synthesis, Crystal Structure and Properties of a 1D Metal-organic Coordination Polymer [Cd(pztmb)2(H2O)2]n
Authors: Zhou Ying , Sun Xi-Meng , Zang Shuang-Quan , Hou Hong-Wei
Published: February 2015

Hydrothermal reaction of Cd(NO3)2 · 4H2O with a flexible asymmetrical bridging ligand, 4-(2- pyrazinylthiomethyl)benzoic acid (Hpztmb), at 120 °C yielded a novel one-dimensional Cd(II) coordination polymer [Cd(pztmb)2(H2O)2]n (1), which has been characterized by IR spectroscopy, elemental analysis, thermogravimetry, and X-ray crystallography. The metal-organic chain of the complex is held together with its neighbors via O-H· · ·O hydrogen bonds and face-to-face π-π interactions leading to a three-dimensional supramolecular network. Compound 1 exhibits a fluorescence emission around 396 nm
Synthesis, Crystal Structure and Magnetic Properties of an Iron(III) Pyridine-2,3,5,6-tetracarboxylate Complex
Authors: Xu Wei , Lin Jian-Li , Zhu Hong-Lin , Hu Fang-Hong , Zheng Yue-Qing
Published: February 2015

A new pyridine-2,3,5,6-tetracarboxylato-bridged Fe(III) complex with a K+ counter ion, K[Fe(H2pdtc)2] (1), was prepared from the reaction of Fe2(SO4)3 ・7H2O, pyridine-2,3,5,6-tetracarboxylic acid and KOH under ambient conditions. The complex has been characterized by singlecrystal and powder X-ray diffraction, IR spectroscopy, TG analysis, elemental analyses, and magnetic measurements. Through intermolecular hydrogen bonding and π-π stacking interactions, the [Fe(H2pdtc)2]− complex anions are assembled into supramolecular double chains with the K+ cations located between them. The variable temperature magnetic measurement has shown a weak ferromagnetic behavior over the range 300 - 10 K followed by antiferromagnetic behavior below 10 K
Reactions of Nitroxides. Part XII [1]. – 2,2,6,6-Tetramethyl-1-oxyl- 4-piperidyl Chloroformate – A New Reactive Nitroxyl Radical. A One-pot Synthesis of 2,2,6,6-Tetramethyl-1-oxyl-4-piperidyl N,N-Dialkyl-carbamates
Authors: Zakrzewski Jerzy , Krawczyk Maria
Published: February 2015

The reactive nitroxides 2,2,6,6-tetramethyl-1-oxyl-4-piperidyl chloroformate and 2,2,6,6-tetramethyl- 1-oxyl-4-piperidyl chlorothionoformate were synthesized from 2,2,6,6-tetramethyl-4-hydroxypiperidin- 1-oxyl and diphosgene (68%) or thiophosgene (61%), respectively. The reactions of the chloroformate and chlorothionoformate with lower secondary amines lead to 2,2,6,6-tetramethyl- 1-oxyl-4-piperidyl N,N-dialkylcarbamates (59 - 94%) and thionocarbamates (35 - 65%), respectively. Unexpectedly, the same 2,2,6,6-tetramethyl-1-oxyl-4-piperidyl N,N-dialkylcarbamates were obtained directly in a one-pot reaction of 2,2,6,6-tetramethyl-4-hydroxypiperidin-1-oxyl with diphosgene and lower tertiary alkylamines by dealkylation in 32 - 86% yield. The antifungal activity of the synthesized carbamates and thionocarbamates has been demonstrated
New Substituted Thiazol-2-ylidene-benzamides and Their Reaction with 1-Aza-2-azoniaallene Salts. Synthesis and anti-HIV Activity
Authors: Saeed Aamer , Al-Masoudi Najim A. , Ahmed Amjed A. , Pannecouque Christophe
Published: February 2015

A series of N-(3-(substituted-alkyl- or halophenyl)-4-methylthiazol-2(3H)-ylidene)-substituted alkyl- or halo-benzamides 21 - 40 were prepared by base-catalyzed cyclization of the corresponding 1-(substituted-alkyl- or halo-benzoyl)-3-(substituted-halophenyl)thioureas 1 - 20. Substituted pyrazolo[ 4,3-d]thiazol-5(6aH)-ylidene)benzamides 45a - d were synthesized by cycloaddition of compound 45 with the reactive cumulene intermediates 42a - d. All compounds were evaluated for their antiviral activity against the replication of HIV-1 and HIV-2 in MT-4. Compounds 35 and 39 showed an IC50 of 2.02 μgmL−1 and 0.40 μgmL−1 against the HIV-2 strain ROD with CC50 of ≥ 104.00 μgmL−1 and > 125.00 μgmL−1, respectively, resulting in a selectivity index of ≥ 52 and > 313. Based on the chemical structure of compounds 35 and 39, these molecules can be proposed to act as NNRTIs. However, it is exceptional to observe an antiretroviral activity that is limited to HIV-2
NQR Study of AlBr3 Complexes with Dimethylsulfide
Authors: Ishihara Hideta , Sirahama Tomoaki , Nakashima Shouko , Terao Hiromitsu , Yamada Koji
Published: February 2015

Br-
Mannich Bases as Synthetic Intermediates: Convenient Synthesis of Functionalized 1,2,4-Triazepines, 1,4-Diazepines and 1,5-Diazocines
Authors: Afsah Elsayed M. , Keshk Eman M. , Abdel-Rahman Abdel-Rahman H. , Jomah Najla F.
Published: February 2015

Transamination between the ketonic Mannich bases 1a, b and primary arylamines gave a series of ketonic sec-Mannich bases 2a - h. A variety of tetrahydro-1,2,4-triazepines 3a - f have been synthesized by treating the arylhydrazones of 2 with formaldehyde. A similar reaction with the benzenesulfonylhydrazone of 2b afforded 4. The 3-styryl-2H-1,2,4-triazepine 5 was obtained from the phenylhydrazone of 2a and cinnamaldehyde. Treatment of arylhydrazones of the 4-methoxystyryl keto base 7 with formaldehyde and cinnamaldehyde afforded the 3,4,5,6-tetrahydro-2H-1,2,4-triazepines 8a, b. Mannich reaction with 4-(p-hydroxyphenyl)-tetrahydro-1,2,4-triazepine 3d afforded the Mannich bases 9, 10 and 11.

The reaction of 1b with o-phenylenediamine leads to the 1,5-benzodiazepine 13. The new tetrahydro- 1,4-diazepine and tetrahydro-1,5-diazocine Mannich bases 15 and 17 were obtained from 1b and ethylenediamine or 1,3-diaminopropane, respectively. The bi(piperidine) derivative 19 was obtained from 1a and 1,3-diaminopropane.
Dialiumoside, an Olean-18-ene Triterpenoid from Dialium excelsum
Authors: Awantu Angelbert F. , Lenta Bruno N. , Bogner Tobias , Fongang Yanick F. , Ngouela Silvère , Wansi Jean D. , Tsamo Etienne , Sewald Norbert
Published: February 2015

Phytochemical investigation of the stem bark and fruits of Dialium excelsum led to the isolation of a new triterpenoid, named dialiumoside (1), together with twelve known compounds (2 - 13). The structure of the new compound as well as those of the known compounds were established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1 - 13 were tested for their cytotoxic activity against the human cervix carcinoma KB-3-1 cells and the related multi drug-resistant P-gp-expressing KB-V1 cells. Compounds 1 and 13 showed weak biological activity in cytotoxicity assays while other compounds were inactive.
Steroids from the South China Sea Gorgonian Coral Muricella flexuosa
Authors: Wang Ping , Qi Shu-Hua , Liu Kai-Sheng , Huang Li-Si , He Fei , Wang Yi-Fei
Published: February 2015

Four new steroidal glycosides and a new steriod linked with a 4-hydroxyphenylmethylene group, namely muricellasteroids A- E (1 - 5), together with one known steroidal glycoside analog, 22α,2ʹ,3ʹ,4ʹ-O-tetraacetyl-27-O-[β -D-arabino-pyranosyl-oxy]-20β -hydroxy-cholest-4- ene-3-one (6), were isolated from the EtOH/CH2Cl2 extracts of the South China Sea gorgonian coral Muricella flexuosa. The structures of 1 - 5 were established by means of 1D- and 2D-NMR and other spectroscopic analyses. Compounds 1 - 3 and 5 - 6 showed moderate cytotoxicity against A375, K562, and A549 cancer cell lines.
Intermetallic Compounds RETMg2 (RE = La, Pr, Nd; T = Ni, Pd, Pt) with MgCuAl2-type Structure
Authors: Kersting Marcel , Pöttgen Rainer
Published: February 2015

The magnesium-rich intermetallic compounds RETMg2 (RE = La, Pr,Nd; T = Ni, Pd, Pt) were obtained by melting of the elements in sealed tantalum ampoules and subsequent annealing. Their structures have been characterized on the basis of powder X-ray diffraction. The RETMg2 phases crystallize with the orthorhombic MgCuAl2-type structure, space group Cmcm. The crystal chemical peculiarities are briefly discussed.
Two Organic Hybrid Thiogermanates [Ni(dien)2]2(H2dien)Ge2S6 and [Ni(teta)2]2Ge4S10
Authors: Liu Xing , Zhou Jian , He Jun , Huang Zhi-wei
Published: February 2015

Two new organic hybrid thiogermanates [Ni(dien)2](H2dien)Ge2S6 (1, dien = diethylenetriamine) and [Ni(teta)2]2Ge4S10 (2, teta = triethylenetetramine) were synthesized under solvothermal conditions. 1 contains a [Ni(dien)2]2+ complex cation, a protonated dien molecule and a [Ge2S6]4− dimeric anion, while 2 consists of discrete [Ge4S10]4− adamantane-like cluster anions with [Ni-(teta)2]2+ complex cations as counter ions. The [Ge4S10]4− anion is composed of four nearly tetrahedral Ge4+ centers to which are bonded four terminal atoms and six bridging S atoms. Luminescence studies have shown that 2 exhibits an emission at 468 nm.
Crystal and Molecular Structure of a New Hydroxylamido/Amino Acid Oxovanadium(V) Complex, [VO(NH2O)2(DL-methioninato)]·H2O
Authors: Piro Oscar E. , Echeverría Gustavo A. , Arrambide Gabriel , Gambino Dinorah , Baran Enrique J.
Published: February 2015

The crystal and molecular structure of the [VO(DLmeth)( NH2O)2]・H2O complex has been determined by X-ray diffraction methods (monoclinic, P21/c with a = 5.8138(2), b = 27.3496(8), c = 7.5663(2) A° , β = 103.059(3)◦, and Z = 4). The vanadium(V) cation is in a pentagonal bipyramidal environment axially coordinated to the oxo group and equatorially to two hydroxylamido groups in a side-on fashion. The fifth equatorial binding site and the other apical position are occupied by an N and an O atom, respectively, from the methioninate anion acting as a bidentate ligand.
Synthesis and Structural Characterization of N,N´- Dipropyl-N,N,N´,N´-tetramethyl-1,2- ethylenediammonium Dichloride and Dibromide
Authors: Närhi Sari M. , Asikkala Janne , Kostamo Jatta , Lajunen Marja K. , Oilunkaniemi Raija , Laitinen Risto S.
Published: February 2015

N,N´-Dipropyl-N,N,N´ ,N´-tetramethyl-1,2-ethylenediammonium dichloride (1) and dibromide (2) were prepared by the reaction of N,N,N´,N´-tetramethyl-1,2-ethylenediamine and the corresponding 1-halopropane. The structures of the compounds were characterized by single-crystal X-ray diffraction. 1 · 2H2O crystallizes in the triclinic crystal system, space group P1, with Z = 1, and 2 in the monoclinic crystal system, space group P21/c, with Z = 2. The crystal structures of the salts consist of discrete dications and halide anions. The packing in 1 · 2H2O consists of layers of cations with the chloride anions and water molecules forming hydrogen-bonded chains between the cation layers. In 2, the strongest H· · ·Br hydrogen bonds of 2.8138(6) and 2.8187(7) °A link the cations and anions into doublestranded chains. In both salts, cations and anions are also linked together by a further weak C-H· · ·Cl/Br hydrogen bonding network.
An Efficient Synthesis of the Glycosidase Inhibitor 1,6-Dideoxy-6,6-difluoronojirimycin
Authors: Csuk René , Prell Erik , Korb Claudia
Published: February 2015

1,6-Dideoxy-6,6-difluoronojirimycin (1) was prepared from an easily accessible and commercially available starting material, methyl 2,3,4-tri-O-benzyl-α-D-glucopyranoside. Key steps of this synthesis are a difluorination reaction using DAST and a reductive amination. The overall yield of the synthesis is 44%. Compound 1 has been tested for its activity as an inhibitor of various glucosidases and galactosidases.
5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part IV. One-pot Synthesis of 1H-Pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione Derivatives Using Controlled Microwave Heating
Authors: Shaker Raafat M. , Sadek Kamal U. , Hafez Ebtisam A. , Elrady Mohamed Abd
Published: February 2015

An efficient and direct procedure for the synthesis of pyrrolo[2,3-d]pyrimidine-2,4-dione derivatives using controlled microwave heating has been described. The products were characterized by elemental analyses, IR, 1H NMR, 13C NMR and MS spectra.
Ab initio Computational Insight into the Interaction of Alkyl-substituted Ethene and Sulfenyl Halide
Authors: Vektariene Ausra , Vektaris Gytis
Published: February 2015

The ab initio calculations approach was used to determine the mechanism of interaction between propene and a sulfenyl halide. The second-order Møller-Plesset corrections for the electron correlation energy were applied to calculate the most probable Gibbs Free Energy profiles for the selected reaction. All optimized structures were confirmed by vibrational frequency analysis and intrinsic reaction coordinate calculations. Two possible reaction pathways were proposed and evaluated to conclusively characterize the reaction. The reaction proceeds via formation of a cyclic episulfonium intermediate, stereoselective ring opening of the episulfonium intermediate by the chloride anion, and isomerization of the adduct of the kinetically controlled reaction into the thermodynamically favorable product.
Synthesis and Crystal Structure of a Green Photoluminescent 1D Cobalt(II) Coordination Polymer Constructed from 2,2` Bibenzimidazole
Authors: Yang Yan , Yan Liu-Ting , Li Xiao , Chen Xian-Ming , Qin Rong-Huan , Duan Wen-Gui
Published: February 2015

Hydrothermal reaction of Co(NO3)2 ·6H2O with H2bibm and H4cta at 120 ◦C yielded a novel 1D Co(II) coordination polymer, [Co(H2bibm)(cta)]n · nH2O (1) [H2bibm = 2,2`-bibenzimidazole, cta = citrate], in which distorted CoN2O4 octahedra are linked by the cta ligands in a tetradentate bridging mode to construct a zigzag chain with Co...·Co distances of 7.510(1) A° . A 2D supramolecular network is formed by π-π stacking with a face-to-face distance of 3.55 °A between the imidazole rings of the 2,2`-bibenzimidazole ligands and interchain O-H· · ·O and N-H· · ·O hydrogen bond interactions. Complex 1 displays strong green fluorescence emissions at 538 nm in th+e solid state upon photoexcitation at 395 nm at room temperature.
Synthesis and Structures of Three- and Hexa-armed Benzene Derivatives Featuring Lateral Benzoic Ester and Benzoic Acid Functions
Authors: Förster Sebastian , Seichter Wilhelm , Weber Edwin
Published: February 2015

The new 1,3,5-tri-substituted and hexa-substituted benzoic methyl esters 1, 3 and benzoic acids 2, 4 have been synthesized. Single-crystal structure determinations of 1 - 3 are reported, which show specific molecular conformations and packings in the crystal. In all structures, the conformation of the molecules deviates considerably from threefold and sixfold symmetry, respectively. Columnar packings are observed in the crystal structures of the esters 1 and 3, stabilized by weak C-H・・・O and C-H・・・π interactions, while the packing of 2 features the formation of supramolecular strands involving the dimerization of the carboxylic acid group.
SrAu4.76In1.24 with YbMo2Al4-type Structure
Authors: Muts Ihor , Matar Samir F. , Rodewald Ute Ch. , Zaremba Vasyl’ I. , Pöttgen Rainer
Published: February 2015

The gold-rich intermetallic compound SrAu4.76In1.24 was synthesized by high-frequence-melting of the elements in a sealed tantalum tube and subsequent annealing. The structure was refined from single-crystal X-ray diffraction data: YbMo2Al4-type, I4/mmm, Z = 2, a = 718.77(7), c = 552.79(9) pm, wR2 = 0.0760, 149 F2 values and 11 parameters. The 4d (0.62 In + 0.38 Au) Wyckoff position shows mixed occupancy leading to the composition SrAu4.76In1.24 for the investigated crystal. The strontium atoms are located in a large cage built up by 12 Au + 8 In atoms. The gold and indium atoms show segregation into substructures. The striking structural motifs are Au4 squares (278 pm Au-Au) and indium chains (276 pm In-In). The squares and chains are connected via weaker Au-Au (299 pm) and Au-In (295 pm) bonds to a three-dimensional network. The In chains show the motif of rod packing. Electronic structure calculations show anisotropy within the structure with different responses to compressions along In-In chains and Au planes, also illustrated by the electron localization contour plots. The metallic behavior is found to be of itinerant electron type (like Cu), and the chemical bonding includes stabilizing Au-In interactions.
Halogen Bonds in Two Silver(I) Mixed-ligand Supramolecular Frameworks: Synthesis, Structure and Photoluminescence
Authors: Sun Di , Huang Rong-Bin , Zheng Lan-Sun
Published: February 2015

Two silver(I) tetrachlorophthalates incorporating aminopyrimidyl ligands, namely [Ag4(apym)4(tcpta)2]n (1) and [Ag2(dmapym)(tcpta)]n (2), (apym = 2-aminopyrimidine, dmapym = 2-amino-4,6-dimethylpyrimidine, H2tcpta = tetrachlorophthalic acid), were synthesized and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Both 1 and 2 form sheets which are assembled into 3D supramolecular frameworks via halogen bonds, hydrogen bonds and π...π interactions. Even adding two more methyl groups to the pyrimidyl ring does not change the dimensions of 1 and 2, but it influences the arrangement of the N- and O-donors in the solid state which in turn results in different types of halogen bonds. The photoluminescence properties of 1 and 2 were investigated in the solid state at room temperature.
Synthesis, Crystal Structure and DNA-Binding Properties of a Cadmium(II) Complex with 2,6-Bis(N-methylbenzimidazol-2-yl)pyridine
Authors: Wu Huilu , Huang Xingcai , Yuan Jingkun , Kou Fan , Jia Fei , Liu Bin , Bai Ying
Published: February 2015

A new complex of Cd(II) picrate (pic) based on the ligand 2,6-bis(N-methylbenzimidazol-2-yl)- pyridine (mbbp) has been synthesized and characterized by elemental analysis, electrical conductivity, 1H NMR, IR and UV/Vis spectral measurements. The crystal structure of the Cd(II) complex, [Cd(mbbp)2](pic)2, has been determined by single-crystal X-ray diffraction. The Cd(II) cation is bonded to two mbbp ligands through six nitrogen atoms, resulting in a distorted octahedral geometry. Interaction of the complex with DNA was investigated by spectrophotometric methods and viscosity measurements. The experimental results suggest that the Cd(II) complex binds to DNA in an intercalation mode.
Synthesis of New Bisphosphonate and Bisphosphonic Acid Derivatives and Heterocyclic and Dialkylcarbamoyl Oxazolone Derivatives with Anticancer and Antischistosomal Activity
Authors: Boulos Leila S. , Ewies Ewies F. , Fahmy Amin F. M.
Published: February 2015

The reaction of 5(4H)-oxazolones with tetraethyl methanediylbis(phosphonate) afforded new 1,1-bisphosphonate and 1,1-bisphosphonic acid derivatives. Moreover, 5(4H)-oxazolones reacted with Wittig reagents to give the corresponding heterocyclic products. Treatment of 5(4H)-oxazolones with trisdialkylaminophosphanes gave the corresponding N-(1-dialkylcarbamoyl)-2-phenylvinylbenzamides. Mechanisms accounting for the formation of the new products are discussed. The biological activity of the newly synthesized compounds was also examined.
Locking Out Ants – Synthesis and Biological Evaluation of Some Fluorinated Repellents
Authors: Csuk René , Tamba Maria Gabriela , Kluge Ralph
Published: February 2015

We synthesized a series of fluorinated compounds and tested them in an easy assay for their repellent activity against the ant Myrmica rubra. Depending on their chain length and pattern of fluorination these molecules are efficient repellents for this ant. Fluorinated compounds are stronger repellents than their unfluorinated analogs. 1,1,1-Trifluorotridecan-2-one (4) is an even better repellent against M. rubra than “gold standard” N,N-diethyl-m-toluamide (DEET).
Diabietane Ether, a New Dimeric Abietane with an Ether Linkage from Taxus cuspidata Needles
Authors: Ni Zhi-Yu , Wu Yi-Bing , Dong Mei , Zhang Man-Li , Wang Yu-Fang , Sauriol Françoise , Huo Chang-Hong , Shi Qing-Wen , Gu Yu-Cheng , Kiyota Hiromasa , Cong Bin
Published: February 2015

Diabietane ether (1), a new abietane dimer connected by an ether linkage, and two known abietane diterpenoids (2 and 3) were isolated from the needles of Taxus cuspidata.
Filling up another Gap: Synthesis and Crystal Structure of Ba2H3I
Authors: Reckeweg Olaf , DiSalvo Francis J.
Published: February 2015

Colorless and transparent single crystals of Ba2H3I were obtained by reacting Ba with dried and sublimed NH4I in a 4 : 1 molar ratio in silica-jacketed Nb ampoules at 1100 K for 13 h. The crystal structure of the title compound was determined and refined by means of single-crystal X-ray diffraction. Ba2H3I crystallizes in a stuffed anti-CdI2 structure isotypic to Sr2H3I in the space group P3̄m1 (no. 164) with the lattice parameters a = 451.86(12) and c = 811.84(23) pm. The structural results for Ba2H3I are consistent with bond lengths and coordination geometries of related binary and ternary hydrides
Syntheses, Single-crystal Structure and Vibrational Spectra of Ca15(CBN)6(C2)2H2
Authors: Reckeweg Olaf , Schulz Armin , DiSalvoa Francis J.
Published: February 2015

Single crystals of Ca15(CBN)6(C2)2H2 were obtained either by the reaction of stoichiometric amounts of graphite, hexagonal BN, and CaH2 with an excess of distilled Ca, or by using graphite, boron powder, Ca3N2, and CaH2 with an excess of distilled Ca. Both reactions took place in silicajacketed Ta ampoules at 1400 K. Crystals of the title compound are transparent dark-red and isopointal to Ca15(CBN)6(C2)2O adopting the cubic space group Ia3̄d (no. 230, Z = 8) with the cell parameter a = 1653.30(17) pm. The vibrational spectra were recorded and are compared with IR and Raman data of isotypic compounds
Structure and Magnetic Properties of a Three-dimensional Cobalt Metal-Organic Framework
Authors: Chen Man-Sheng , Li Wei , Zhang Man-Bo , Hu Rui-Xiang , Zhang Chun-Hua , Chen Zhi-Min
Published: February 2015

A new 3D fourfold interpenetrated metal-organic framework, [Co(L)2(SO4)]・H2O (1), has been synthesized by the solvothermal reaction of L with CoSO4・6H2O (L = 1,4-bis(imidazolyl)benzene). Compound 1 crystallizes in the monoclinic space group P21/n, with the cell parameters: a = 9.943(2), b = 21.7104(15), c = 13.2658(18) Å , β = 97.638(3)◦, V = 2838.2(8) Å3, R1 = 0.0566 and wR2 = 0.1035. It represents a novel dia net, in which the cobalt atoms are alternately bridged by the imidazolyl N atoms of the ligands L into a three-dimensional network. Compound 1 displays antiferromagnetic interactions. From 2 to 300 K, χm −1 it obeys the Curie-Weiss law with C =2.68 emu K mol−1 and Θ = −2.59 K
The Solid Solution Lu2–xScxSiO5
Authors: Yahia Hamdi Ben , Rodewald Ute Ch. , Heying Birgit , Balamurugan Sarkarainadar , Pöttgen Rainer
Published: February 2015

The monoclinic silicates Lu2SiO5 and Sc2SiO5 (Y2SiO5 type, space groupC2/c) forma solid solution Lu2−xScxSiO5. Samples with x = 0.5, 0.8, 1.0 were synthesized ceramically from Lu2O3, Sc2O3, and SiO2. The structures of three crystals with x = 0.88, 0.77, and 0.50 were refined on the basis of single-crystal X-ray diffraction data. The rare earth (RE) atoms occupy two crystallographically different 8ƒ sites with oxygen coordination numbers (CN) of 6 (RE2) and 7 (RE1). Refinements of the occupancy parameters showed Lu/Sc mixing for both sites with a strong preference of the smaller scandium atoms for CN6
Crystal Structure and Catalytic Properties of (C6H8N)3[PMo12O40]
Authors: Cai Tie-Jun , Lü Shu-Zi , Zhang Chuan-Lei , Huang Yi-lan , Liu Ren-yuan , Deng Qian
Published: February 2015

The 4-picolinium salt (C6H8N)3[PMo12O40] was synthesized hydrothermally and characterized by IR spectroscopy, TG-DTA data and single-crystal X-ray diffraction. The results indicate that the compound consists of a [PMo12O40]3− heteropolyoxoanion and 4-picolinium cations [C6H8N]+. A supramolecular structure is formed via intermolecular hydrogen-bonding between the different structural units. Crystal data: monoclinic, space group P21/c, a = 19.7004(3), b = 14.0785(2), c = 33.0209(5) Å, β = 91.3590(10)°, V = 9155.8(2) Å3, Z = 8, wR2 = 0.0730. (C6H8N)3[PMo12O40] has a high catalytic activity for the oxidative elimination of acetone from gases as tested in a continuousflow fixed-bed micro-reactor. When the initial concentration is 5.2 gm−3 in air, and the flow rate is 3.3 mLmin−1, 93% of the acetone is eliminated at 70 °C.
Theoretical Description of the Coding Potential of Diamino-5-formamidopyrimidines
Authors: Cysewski Piotr , Oliński Ryszard
Published: February 2015

The results of geometry optimisation of possible Watson-Crick-like pairs o f 2,6-diamino-4-oxy-5-formamidopyrimidine (fapy-adenine) or 4,6-diamino-5-formamidopyrimidine (fapy-guanine) were presented. In the absence of the external field the fapy-adenine is able to form pairs with all four canonical nucleic acid bases. However, pairs with guanine, cytosine and thymine the most stable are. Thus, the potential miscoding abilities may be observed. In contrast, in the presence of the external field the mispairing abilities of fapy-adenine become insignificant since the most stable dimers are formed with thymine.

The pairing properties of fapy-guanine are complex and depend on its tatomeric form. In the absence of an external field the 4-enol-6-keto-diamino tautomer of fapyG is able to form stable dimers with thymine and cytosine, while the 4,6-diketo-diamino tautomer forms the most stable pairs with cytosine and guanine. The presence of the water solvent does not significantly alter the pairing abilities of fapy-guanine. However, pairs with thymine are at least as stable as the Watson-Crick GC pair. Thus, in polar conditions the mispairing potential of fapyG will be extended and may be enriched by potential GC → AT transition.
Bioactive Terpenes from the Soft Coral Heteroxenia sp. from Mindoro, Philippines
Authors: Edrada Ru Angelie , Wray Victor , Witte Ludger , Ofwegen Leen van , Proksch Peter
Published: February 2015

A marine soft coral species of the genus Heteroxenia collected from Mindoro Island, Philippines yielded two cadinene sesquiterpenes, (+)-α-m uurolene (1) and a novel derivative (+)- 6 -hydroxy-α-muurolene (2 ), as well as the biologically active polyhydroxysterol, sarcoaldosterol A (3). The structure of the novel compound was unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long range 13C -1H correlations) and mass spectrometric (EIMS) data. All compounds were active against the phytopathogenic fungus Cladosporium cucumerinum. The isolated terpenes were also active in the brine shrimp lethality test.
A Pyoverdin from Pseudomonas sp. CFML 95-275§
Authors: Sultana Razia , Fuchs Regine , Schmickler Hans , Schlegel Karin , Budzikiewicz Herbert , Siddiqui Bina Shaheen , Geoffrey Valerie , Meyer Jean-Marie
Published: February 2015

From Pseudomonas sp. CFML 95-275 a pyoverdin was isolated with a cyclopeptidic substructure. It could be shown that this pyoverdin is identical with one obtained from Pseudomonas fluorescens BTP 7 for which a lactone structure had been deduced from the interpretation of a FAB spectrum. The elucidation of the correct structure of the pyoverdin is described.
Antimicrobial Activities of Ferulago Essential Oils¥
Authors: Demirci Fatih , İşcan Gökalp , Güven Kiymet , Kirimer Neş′e , Can Başer Kemal Hüsnü
Published: February 2015

Essential oils from Ferulago asparagifolia Boiss., F. galbanifera (Miller) W. Koch, F. humilis Boiss. (Endemic), F. trachycarpa Boiss. growing in Turkey were evaluated against 15 microorganisms for their antifungal and antibacterial activity using an agar tube dilution and microdilution broth susceptibility assay, respectively. The essential oil compositions were investigated by GC/MS. Inhibitory effects against Escherichia coli, Enterobacter aerogenes, Candida albicans, Gaeumannomyces graminis var. tritici, Sclerotium rolfsii and Fusarium moniliforme were remarkable. Results are discussed in comparison with the chemical composition of the essential oils.
Removal of Magnesium by Mg-dechelatase Is a Major Step in the Chlorophyll-Degrading Pathway in Ginkgo biloba in the Process of Autumnal Tints
Authors: Tang Lei , Okazawa Atsushi , Fukusaki Eiichiro , Kobayashi Akio
Published: February 2015

Autumnal tints are one of the most manifest and fascinating natural phenomena, but the mechanism of chlorophyll (Chl)-breakdown in deciduous trees has not been fully elucidated. In this study, we analyzed the composition of Chl-related compounds and determined the activities of initial Chl-degrading enzymes in Ginkgo leaves at various stages in the process of autumnal coloring. Only pheophytin a (Pheo a, Mg-free Chl a) was detected in yellow leaves by HPLC analysis, and the activity of Mg-dechelatase in yellow leaves was found to be higher than in green leaves. These findings showed that the removal of magnesium from Chl a occurred in advance of dephytylation in the Ginkgo.
Enzymatic Hydrolysis of Carotenoid Fatty Acid Esters of Red Pepper (Capsicum annuum L.) by a Lipase from Candida rugosa
Authors: Breithaupt Dietmar Ernst
Published: February 2015

Analyses of red pepper extracts which had been pretreated with lipase type VII (EC 3.1.1.3.) from Candida rugosa showed for the first time pepper carotenoid esters to be substrates of this enzyme. However, the extent of enzymatic hydrolysis depends on the respective carotenoid and was not quantitative compared to chemical saponification. After enzymatic cleavage, 67-89% of total capsanthin, 61-65% of total zeaxanthin, 70-81% of total β-cryptoxanthin and 70-86% of total violaxanthin were detected in free form. Nevertheless, the method described here offers the possibility to cleave in part several carotenoid esters originating from red pepper quickly and under comparatively mild reaction conditions. Replacement of the generally performed alkaline hydrolysis by enzymatic cleavage allows the resulting product to be used in food industry as “natural” coloring agent e.g. to colour cheese and jellies.
Cyanophora paradoxa: Nucleotide Sequence and Phylogeny of the Nucleus Encoded Muroplast Fructose-1,6-bisphosphate Aldolase
Authors: Nickol Albin A. , Müller Norbert E. , Bausenwein Ursula , Bayer Manfred G. , Maier Thomas L. , Schenk Hainfried E. A.
Published: February 2015

Immunoscreening of a C. paradoxa expression library against water soluble muroplast (“cyanelle”) proteins resulted in isolation of a clone encoding the nucleus-encoded muroplast class-II fructose-1,6-bisphosphate aldolase (class-II FBA§). Its nucleotide sequence was determined. The 1432 bp insert, derived from a single-copy gene transcript, bears a reading frame of 1206 bp in length, representing 402 amino acids with 346 amino acids of mature protein. The leading amino acids match structural features necessary for precursor import across chloroplast envelope membranes. In phylogenetic tree topology, the investigated mature FBA clusters within type B FBAs with Synechocystis sp. as nearest neighbor. This is the first report of a Type B class-II FBA sequence of plastids.
Antinociceptive Properties of Morusin, a Prenylflavonoid Isolated from Morus nigra Root Bark
Authors: Souza Márcia Maria de , Bittar Magali , Cechinel-Filho Valdir , Yunes Rosendo Augusto , Messana Irene , Monache Franco Delle , Ferrari Franco
Published: February 2015

The antinociceptive effects of morusin (1), the main prenylflavonoid present in the Morns nigra root barks have been investigated in classical models of pain in mice. The results showed that 1 exhibits a prom ising antinociceptive or analgesic profile by the intraperitoneal route, being more potent than some standard drugs used as reference. The mechanism by which the morusin exerts antinociceptive activity still remains undetermined, but our results strongly suggest that it involves the participation of the opioid system.
Antinematodal Activity of Some Tropical Rainforest Plants against the Pinewood Nematode, Bursaphelenchus xylophilus
Authors: Alen Yohannes , Nakajima Shuhei , Nitoda Teruhiko , Baba Naomichi , Kanzaki Hiroshi , Kawazu Kazuyoshi
Published: February 2015

Sixty five methanolic extracts of Sumatran rainforest plants representing 63 species of 21 families were assayed in vivo for antinematodal activity against Bursaphelenchus xylophilus using our cotton ball-fungal mat method. Extracts of 27 plants species from 14 families exhibited antinematodal activity, while 37 species were inactive. Among them, three extracts of Bischofia javanica, Knema hookeriana and Areca catechu exhibited very strong activity at minimum effective dose (MED ) of 0.7 mg/cotton ball (mg/bl.). Eight extracts from Allamanda cathartica, Ervatamia corymbosa, Hoya diversifolia, Bischofia javanica, Derris malacensis, Melastoma melabathricum, Ophiorriza konsteleary and Brucea sumatrana also showed strong activity (MED, 5 mg/bl.).
Induction of DNA-Protein Cross-Links by Platinum Compounds
Authors: Woźniak Katarzyna , Walter Zofia
Published: February 2015

The differences between cis- and trans-diamminedichloroplatinum II (DDP) in forming DNA-protein cross-links in isolated human lymphocytes were investigated. Both cis- and trans-DDP can induce DNA-protein cross-links. We show that cis-DDP forms complexes between DNA and proteins faster than trans-DDP. This results from an increase in the quantity of DNA and platinum together with an increase in drug concentration. Under the same conditions trans-DDP causes a decrease in DNA-forming complexes with proteins. After a 12 h incubation of lymphocytes we observe a similar level of DNA in DNA-protein crosslinks induced by DDP isomers, but more platinum appears in complexes induced by trans- DDP. The results obtained demonstrate that the antitumor drug - cis-DDP and the clinically ineffective trans-DDP induce links between DNA and proteins in a different manner. We suggest that the therapeutic activity of ds-DDP can in part arise from rapidly forming DNA-protein complexes which can destroy the most important cellular processes, such as replication and transcription.
Volatile Compounds of Cashew Apple (Anacardium occidentale L.)
Authors: Bicalho Beatriz , Rezende Claudia M.
Published: February 2015

The volatile compounds of a largely consumed Brazilian cashew apple variety (Anacardium occidentale L. var. nanum , Anacardiaceae) were recovered by headspace extraction or simultaneous distillation-extraction. Several compounds including esters (29), terpenes (16), hydrocarbons (9), carboxylic acids (7), aldehydes (7), alcohols (3), ketones (2), lactones (2) and norisoprenoids ( 1 ) were characterized and quantified by gas chromatography-mass spectrometry analyses.