bluuebunny/crossref_metadata_2025 huggingface dataset:
RESULTS OF SURGICAL AND COMBINATION TREATMENT FOR RECTAL CANCER
Authors: Chissov V. I. , Frank G. A. , Sidorov D. V. , Mainovskaya O. A. , Troitsky A. A. , Lozhkin M. V. , Grishin N. A. , Petrov L. O
Published: December 2023

The results of surgical versus combination treatment for rectal cancer (RC) were analyzed. Changing from the standard, the so-called orthodox, surgery for RC to total mesorectumectomy (TME) could considerably reduce the rate of local recurrences and improve the functional results of treatment. However, there has still been no general use of TME as the operation of choice for RC. The results of examining and treating 542 patients with stage I-IV RC treated at the Herzen Moscow Oncology Research Institute in 1982 to 2010 inclusive were studied. Combination treatment was performed in 242 patients. TME was used in 112 patients. The mean duration of surgery was 211.4±79.1 and 282.2±67.9 min in the non-TME and TME groups, respectively (p < 0.05). In these groups, the frequency of early postoperative complications was 43.3 and 24.1%, respectively (χ 2 = 15.31; p = 0.0009). In the TME group patients who had undergone potentially radical operations, three-year overall survival was 85.9% versus 67.4% in the non-TME group (p = 0.181). In these groups, tumor-specific survival was 89.1 and 77.0%, respectively (p = 0.116).
ROLE OF EPITHELIAL ANTIGEN BER-EP4 IN THE STUDY OF EXUDATES FROM SEROUS SACS
Authors: Volchenko N. N. , Borisova O. V.
Published: December 2023

Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of the Russian Federation Serous exudates with epithelial antigen BER-EP4 were studied using immunoperoxidase, immunofluorescence, and immunocytochemical methods and by a laser flow cytoflurometric technique. Up-to-date high-technologies make it possible to detect few tumor complexes in the exudate at early metastatic stages, which are undetectable by the routine cytological assay and to decrease the rate of hyperdiagnosis of a tumor process. The high efficiency and rapidity of immunofluorescence study of exudates are shown to establish the extent of the tumor process during urgent intraoperative studies.
IN VIVO PHOTO-INDUCED ACTIVITY OF POSITIVELY CHARGED ZINC PHTHALOCYANINE USED FOR PHOTODYNAMIC THERAPY FOR MALIGNANCIES
Authors: Morozova N. B. , Yakubovskaya R. I. , Chissov V. I. , Negrimovsky V. M. , Yuzhakova O. A.
Published: December 2023

The substituted phthalocyanine complex cholosens was in vivo investigated as a photosensitizer used in photodynamic therapy (PDT) for malignancies. Cholosens immediately accumulates in the tissues of murine tumors (Lewis lung carcinoma (LLC), colon adenocarcinoma 26 (C26), sarcoma 37 (S37), and melanoma B16) imaged by fluorescence to show contrast of tumor compared to adjacent tissue from 2 to 4 conventional units. The maximum tumor fluorescence the λ тах = 696.5 nm is recorded 5-30 minutes after injection. Cholosens has a high photo-induced activity against tumors of different genesis. The use of effective PDT regimes (cholosens, 0.5-1.0 mg/kg; interval, At 5-30 min; energy density, 90-180 J/cm 2) yields high treatment results: tumor growth suppression is 81.8-98.6%; higher survival rates are 49.0-115.3%; recovery index is 25.0-66.7%. LLC, C26, and S37 are most susceptible to PDT with cholosens. The later is a promising photosensitizer used in PDT for malignancies and for antimicrobial PDT.
LYNCH SYNDROME AND SPORADIC COLORECTAL CANCER: CLINICAL AND GENEALOGICAL FEATURES
Authors: Chudina A. P.
Published: December 2023

Two hundred and one families that had cases of colorectal cancer among first-degree relatives and had been followed up for at least 5 years were selected from the Moscow Familial Cancer Registry and divided into 3 groups: 1) 6 families with Lynch syndrome (hereditary nonpolyposis colorectal cancer); 2) 36 cancer families without Lynch syndrome; 3) 159 noncancer families. Comparative analysis has shown that the families with Lynch syndrome significantly differ from those of two other subgroups in the following respects: 1) hereditary cancer loading (cancer cases in more than 60% of relatives over 20 years of age); 2) high incidence rates for multiple cancers in women; 3) more common cancer involvement of the colon than the rectus; 4) cancer of the corpus uteri is a second malignancy after colorectal cancer among women; 5) primary malignancies occur 10-20 years earlier with the tumor-specific survival being 5-7 years longer than in the two other groups; 6) during a 5-year follow-up, new cancer cases occurred among first-degree and first-to-third-degree relatives in 50 and 83% of the families, respectively. The cancer families differed from noncancer ones only in general hereditary cancer loading (35.6 versus 12.5%) and in the rate of new cases in first-to-third relatives (33.3% versus 10.7%).
MATURE ANTERIOR UPPER MEDIASTINAL TERATOMA COMPLICATED BY PERFORATION INTO THE LUNG
Authors: Pikin O. V. , Kolbanov K. I. , Makanin M. A. , Kazakevich V. I. , Rudakov R. V. , Korolev A. V.
Published: December 2023

The paper describes a rare case of mature mediastinal teratoma complicated by perforation into the lung. It shows the feasibilities of chest ultrasound study in the preoperative diagnosis of this complication. Radical surgical intervention is the method of choice for treating this category of patients.
BASIC PRINCIPLES OF THE ULTRASOUND DIAGNOSIS OF ESOPHAGEAL, GASTRIC, AND COLON TUMORS
Authors: Mitina L. A. , Khomyakov V. M. , Stepanov S. O.
Published: December 2023

Ultrasound studies were performed for tumors of the gastrointestinal tract (esophageal bullae in 243 patients, stomach in 606, colon in 226, rectum in 197, and anal canal in 26). An ultrasound semiotics of for gastrointestinal tract tumors was developed. The potentials of ultrasonography in imaging tumors and defining their local extent were studied in relation to the tumor site. The method showed its high clinical efficiency. The possibilities of using three-dimensional (3D) repair for gastrointestinal tumors were studied.
USE OF COLETEX-GEL-DNA AND COLETEX-GEL-DNA-L IN PATIENTS WITH OROPHARYNGEAL MALIGNANCIES TO PREVENT AND TREAT ACUTE RADIATION REACTIONS
Authors: Velsher L. Z. , Boiko A. V. , Shipilina N. P. , Reshetov D. N. , Korobkova A. Yu. , Kosmynin A. A.
Published: December 2023

The efficacy of topical Coletex-gel-DNA and Coletex-gel-DNA-L was analyzed in the radiotherapy of patients with otopharyngeal malignancies. The application of these agents was found to significantly reduce the magnitude of grade III radiation-induced oral and pharyngeal reactions from 66.8 to 24.6% as compared to the classical way of preventing these reactions.
HPV-ASSOCIATED OROPHARYNGEAL CANCER (A CLINICAL CASE)
Authors: Gevorkov A. R. , Boiko A. V. , Chernichenko A. V. , Daryalova S. L. , Zavalishina L. E. , Ryazantseva A. A. , Sokolov V. V. , Gladyshev A. A.
Published: December 2023

In recent years, human papillomavirus (HPV)-related oropharyngeal tumors have been more frequently detected in the world. Their proportion is 20 to 90% depending on the spread of smoking and the rate of alcohol consumption in the country conducting a study. On the other hand, the proportion of HPV-related squamous cell carcinoma of the oral and pharyngeal mucosae is higher in the countries loyal to sexual norms. According to recent data, HPV-related oropharyngeal cancer should be considered as an individual nosological entity characterized by a tendency to regional metastases generally in relatively small primary tumors and by a high sensitivity to chemotherapy and radiotherapy. The paper describes the experience in successfully treating a 56-year-old patient with locally advanced oropharyngeal cancer and HPV infection.
RISK FOR POLYNEOPLASIAS CONCURRENT WITH THYROID CANCER IN THE NOVGOROD REGION
Authors: Cherenkov V. G. , Chistyakova T. V. , Kovalev D. N. , Khazov A. V.
Published: December 2023

In the Novgorod Region, every 3-4 cases of thyroid cancer (TC) were ascertained to be concurrent with synchronous or metachronous second malignancy. Over 8 years, the incidence of polyneoplasias per 100 first detected patients with TC averaged 28.6, mainly among women (1:10.1). The highest risk for TC is seen in patients with endometrial cancer (1:49), next in those with breast cancer (1:57), in whom the risk factors for malignancy are 3.6 and 3 times higher, respectively, than those in the general population of Novgorod women. Introduction of the mandatory clinical examination minimum for registered patients irrespective of the site of a primary tumor and age, could increase the proportion of patients with detectable Stages I and II polyneoplasias concurrent with TC from 50 to 69.9%.
LATE RADIATION DAMAGES DURING DIFFERENTLY FRACTIONATED CHEMORADIOTHERAPY FOR OROPHARYNGEAL CANCER
Authors: Radzhapova M. U. , Mardynsky Yu. S. , Gulidov I. A. , Semin D. Yu. , Medvedev V. S. , Ivanova I. N.
Published: December 2023

The tolerability of chemoradiotherapy procedures by irregularly adjusting a daily dose and standard radiation was studied by the toxic effect of late radiation damage to the normal tissues and organs of the oral cavity and oropharynx. There were 221 clinical cases of primary cancer of the oral and oropharyngeal mucosa. Late radiation damages to normal tissues and organs occurred in 31 (14%) of the 221 treated patients in different periods. Moreover, they happened in 20.2% of the patients after radiation therapy and in 8.9 and 10.8% after chemoradiotherapy by dividing the dose into 1+1.5 and 1+2 Gy, respectively (p > 0.05). The findings suggest that the tolerability of simultaneous differently fractionated chemoradiotherapy is satisfactory according to the late toxicity criteria - radiation damage to normal tissues and organs in the radiation area.
SIGNIFICANCE OF DNA-FLOW LASER CYTOMETRY IN A DIFFERENTIAL CYTOLOGICAL DIAGNOSIS AND PROSTATE CANCER PROGNOSIS
Authors: Tevryukova N. S , Bogatyrev V. N
Published: December 2023

The article presents results of clinicopathologic research of material obtained from 160 patients with prostate cancer. Cytological research of transrectal puncture biopsy (TPB) detected 159 (96,4%) patients with adenocarcinoma of various differentiation grade and 1 (0,6%) patient with transitional cell carcinoma. Cytological method’s information value in prostate cancer’s (PC) diagnosis in TPB materials such as receptivity, specificity and accuracy showed 90,0%. Clinical trial of tumor ploidy and proliferative activity from archive histological material of 35 (21,9%) patients with PC has been conducted. Aneuploid tumors were prevalent for 26 (74,3%) patients with PC, diploid tumors were detected in materials of 9 (25,7%) patients.
PREDICTORS OF THE EFFICIENCY OF RADIATION/CHEMORADIATION TREATMENT FOR SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Authors: Gevorkov A. R. , Boiko A. V. , Zavalishina L. E. , Chernichenko A. V.
Published: December 2023

Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of Russia The role of radiotherapy in treating head and neck tumors is on the increase, which is associated with a tendency for organ-saving treatment and with a need for a combination and comprehensive approach in case of locally advanced cancer. At the same time, only group prediction is already insufficient in clinical practice to define adequate treatment for these patients; and an individual approach to defining indications for radiotherapy is increasingly greater importance. Despite the fact that the generally accepted clinical and morphological parameters are rather informative in choosing an adequate local and systemic treatment; however, they are insufficiently individual. There is a need for putting into practice the new predictors of the efficiency of radiotherapy, which make it possible to optimize treatment policy, thus improving its results.
Differential diagnosis of surgical gastrointestinal complications in patients with non-Hodgkin’s lymphomas
Authors: Nered S. N , Shalenkov V. A , Stilidi I. S , Osmanov E. A
Published: December 2023

The study includes 190 patients with nodal and extranodal non-Hodgkin’s lymphoma who developed or suspected surgical complications (bleeding, perforation, stenosis) in the gastro-intestinal tract (GIT). Complications in 134 patients occurred in the area of the gastrointestinal tumor lesions, 19 - in different parts of the gastrointestinal tract, which were not involved in the neoplastic process. In 37 patients suspected acute surgical pathology was not confirmed, it was caused by the side effects of anticancer drugs. Examination algorithm and a set of diagnostic features used to distinguish the true surgical complications from side effects of chemotherapy were presented.
POTENTIALS OF RADIOTHERAPY IN THE TREATMENT OF ISOLATED CUTANEOUS MELANOMA METASTATIC TO THE LIVER
Authors: Zakurdyaeva I. G.
Published: December 2023

The paper describes a case of successful palliative radiotherapy for solitary cutaneous melanoma metastatic to the liver in an 82-year-old male patient with age-related concomitant cardiovascular and respiratory diseases. The high risk forced surgery to be avoided. When the procedure of radiation is adequate, its responses are moderate.
ROLE OF MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF CANCER OF THE CERVIX UTERI
Authors: Rubtsova N. A. , Novikova E. G. , Puzakov K. B. , Antipov V. A.
Published: December 2023

Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of Russia The review shows the capacities of magnetic resonance imaging (MRI) in the diagnosis of cancer of the cervix uteri. It also gives the results of analyzing the accuracy of MRI for the preoperative estimation of tumor extent, including for the detection of parametric fat invasion, versus those of clinical examination and other medical visualization methods.
PROGNOSTIC CHARACTERISTICS OF VASCULAR ENDOTHELIUM CONDITION IN OPERATED CANCER PATIENTS
Authors: Olzhaev S. T , Lazarev A. F
Published: December 2023

The study was conducted using multi-disciplinary area of modern medicine - the study of the vascular endothelium. The purpose of the study is to determine the significance of morphological and functional abnormalities of the vascular endothelium during postoperative course in patients with malignancies pancreaticoduodenal zone. The study included 76 patients with malignant neoplasms of pancreaticoduodenal zones at the II-IV clinical stage. The findings revealed two main points. The rate of endothelial dysfunction in cancer patients with postoperative complications is higher than among the patients without complications. The most significant abnormalities are revealed in indicators associated with hemostasis. Correction of endothelial disorders can be the potential way to reduce the risk of postoperative complications.
BREAST CANCER: MORBIDITY, MORTALITY, SURVIVAL (A POPULATION-BASED STUDY)
Authors: Merabishvili V. M.
Published: December 2023

Breast cancer morbidity, mortality, and survival were examined in a population-based study. The survival rate is the most objective criterion to assess the activity of a cancer service. Analysis of trends in the 5-year observed and relative survival rates of women with breast cancer in 1994 to 2003 could reveal their rises from 60.5 to 65.8 and from 71.2 to 77.2%, respectively. One-year observed and relative survival rates in 1994 to 2008 increased from 84.7 to 88.3 and from 87.4 to 90.6%, respectively. There was a great difference in the survival rates in breast cancer patients treated at specialized cancer hospitals versus those at general surgical hospitals.
RECONSTRUCTIVE PLASTIC SURGERY FOR BREAST CANCER
Authors: Volchenko A. A. , Pak D. D.
Published: December 2023

Breast cancer is the most common malignant neoplasm in women. Radical mastectomy is an integral component of its treatment, but this increases survival rates and the number of disabled persons. Emphasis has been recently made on the improvement of quality of life in patients with breast cancer. Today breast reconstructive surgery is an important component in the general treatment regimen. Breast reconstruction ameliorates psychological trauma associated with mastectomy; the women lose a feeling of mutilation, depression, and apprehension of their femininity. A variety of modifications and options for reconstructive interventions creates the choice problem to be solved together with the patient.
A REGIONAL POSITRON EMISSION TOMOGRAPHY CENTER: ASSESSMENT OF INITIAL RESULTS
Authors: Vazhenin A. V. , Afanasyeva N. G. , Vazhenina D. A. , Zotova A. S. , Chashchukhin D. N. , Vaganov N. V. , Kalantayev D. B. , Trofimov D. V. , Varennikova A. A. , Ozerov E. A.
Published: December 2023

The first regional positron emission tomography (PET) center was established in the Chelyabinsk Regional Clinical Oncology Dispensary. PET in combination with computed tomography (PET/CT) was performed in 374 patients with cancer of various sites. The first results of this investigation have indicated that PET/CT is a high-information tool to estimate the extent of malignant tumors; PET/CT could change the stage of the disease and accordingly choose a proper treatment policy in 22.3% of cases. The study contributed to the early detection of recurrences in patients after combination treatment. PET/CT enhanced the effective evaluation of chemotherapy, which led to its timely correction in a number of cases.
CLINICOMORPHOLOGICAL QUANTITY PARALELLS OF THE ARGIROPHILIC PROTEINS OF NUCLEOLAR ORGANIZERS REGIONS IN ADENOCARCINOMA OF THE LUNG
Authors: Kobyakov D. S , Klimachev V. V , Avdalyan A. M , Bobrov I. P , Bychkova E. Yu
Published: December 2023

The argirophilic proteins associated with nucleolar organizers areas (Ag-NOR) in adenocarcinomas of a lung were investigated. Coloring with nitrate silver was carried out according to the standardized protocol. Ag-NOR index area and variation coefficient were defined by the computer analysis of images. Statistically significant differences of Ag-NOR Square index for groups of indicators of T (only for T1), N, primary node 3 cm in size and more, disease stages (only for the I stage) and a tumor differentiation (only for high-differentiated) are received. The variation coefficient of Ag-NOR was statistically significant at differentiation of tumors up to 3 cm and more in high-differentiated moderated and low-differentiated adenocarcinomas. Coefficient determination of Ag-NOR protein variation is less significant in comparison with Ag-NOR Square by comparison of these data to morphological parameters of lung adenocarcinomas.
ANTIONCONEURAL ANTIBODIES AND PARANEOPLASTIC NEUROLOGICAL SYNDROME
Authors: Shnaider N. A. , Dykhno Yu. A. , Ezhikova V. V. , Kantimirova E. A.
Published: December 2023

The review presents data on the role of tumor antigens and antionconeural antibodies in the development of paraneoplastic neurological syndrome.
Morphological changes during Geren carcinoma after cryoablation, a local microwave hyperthermia and their combination
Authors: Samedov V. H , Naleskina L. A , Zakharychev V. D
Published: December 2023

A morphological and morphometric study of Guerin carcinoma after cryoablation, local microwave hyperthermia and their combination was performed. Combined exposure was associated with decreased adhesion of tumor cells, increasing the area of necrotic tissue and more expressed angionecrosis compared with independent use of cryoablation or microwave hyperthermia. The results suggest a more expressed degradation of the Guerin carcinoma tumor tissue by the combined use of low temperatures and microwave hyperthermia.
TEMOZOLOMIDE IN MALIGNANT ASTROCYTIC GLIOMAS
Authors: Borisov K. E. , Sakayeva D. D.
Published: December 2023

The review of literature provides information on the use of temozolomide in the treatment of malignant astrocytic gliomas. The drug is the standard chemotherapy for recurrent malignant gliomas, by being superior to other agents in relapse-free survival rates, without substantially affecting overall survival. Temozolomide is also a standard component of chemoradiotherapy for new-onset glioblastoma multiforme. A combination of temozolomide and other drugs does not outperform monotherapy with the former in most cases. However, there is its synergism with platinum preparations and the inhibitors of topoisomerase and integrin receptor, which makes it urgent to develop new treatments against for gliomas. Alternative temozolomide regimens may be useful in overcoming the resistance to the drug and in minimizing its toxicity.
ENDOTHELIAL DYSFUNCTION AND SYSTEMIC INFLAMMATORY RESPONSE SYNDROME IN PATIENTS WITH PANCREATIC HEAD CANCER
Authors: Lazarev A. F , Doskaliev Zh. A , Olzhaev S. T
Published: December 2023

The purpose of the study - to determine the degree of endothelial dysfunction in the dynamics of the perioperative period in patients with cancer of the pancreatic head in relation to the development and course of systemic inflammatory response syndrome. A total of 42 patients with cancer of the pancreatic head, underwent radical surgery. The parameters of the vascular endothelium: the number of circulating endothelial cells, the content of NO metabolites in blood and excretion, the content of von Willebrand factor in the blood, the level of endothelium-dependent vasodilation, the development of systemic inflammatory response syndrome have been determined. It has been revealed that the presence of endothelial dysfunction signs before surgical intervention corresponds to an increase risk of systemic inflammatory response after surgery was significantly correlated with its constituent symptoms.
INCIDENCE OF MALIGNANT NEOPLASMS OF THE BONE AND ARTICULAR CARTILAGE IN SIBERIA AND THE FAR EAST
Authors: Pisareva L. F. , Anisenya I. I. , Lyakhova N. P. , Boyarkina A. P. , Odintsova I. N.
Published: December 2023

The authors studied the incidence of malignant neoplasms of the bone and articular cartilage (BAC) in Siberia and the Far East over 1994-2008. The regional, time, and age characteristics of BAC malignancies were analyzed using the sex and age intensive and standardized incidence rates (world standard) per 100,000. Analysis of the results of examining 7069 patients diagnosed as having BAC malignancy over 1994-2008 showed that in the average the regions of Siberia and the Far East showed a reduction in the incidence of malignancies at these sites; its peak being was notified in a 60-74-year age group. Higher incidence rates of BAC malignancies were registered in children aged 15-19 years.
Relationship between argyrophilic proteins of nucleolar organizer regions and antigen ki-67 with clinical and morphological parameters and survival in lung adenocarcinoma
Authors: Kobyakov D. S , Klimachev V. V , Avdalyan A. M , Bobrov I. P , Lazarev A. F
Published: December 2023

Investigated argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) and Ki-67 antigen in lung adenocarcinoma. Defined tumor with low and high content of Ag-NOR proteins and proliferation index (PI) Ki-67. The content of Ag-NOR proteins had a relationship with the clinical and morphological parameters: parameters T, N, tumor size to 3 cm or more, stage of the disease. Survival of patients with lung adenocarcinoma is better in tumors with a low content of Ag-NOR proteins or PI Ki-67. High survival rate associated with low content of Ag-NOR proteins and PI Ki-67, low - with high content of Ag-NOR proteins and PI Ki-67, intermediate - with opposite values of the content of Ag-NOR proteins and PI Ki-67. Tumor size, parameter N and content of Ag-NOR proteins had an independent effect on survival. In lung adenocarcinoma with no metastasis to lymph nodes survival related to the size of the tumor, with metastases - with content of Ag-NOR proteins. Mutual study of Ag-NOR proteins and antigen Ki-67 has differential diagnostic and prognostic value in lung adenocarcinoma.
REASONABILITY OF THE PRIMARY TUMOR REMOVAL IN METASTATIC BREAST CANCER PATIENTS AT INITIAL PRESENTATION
Authors: Chernova E. V , Khaylenko V. A , Artamonova E. V , Laktionov K. P , Trofimova O. P , Manzjuk L. V , Komov D. V
Published: December 2023

Treatment of patients with newly diagnosed metastatic breast cancer is based on the drug and radiation therapy. Extraction of the primary tumor is generally not recommended. We examined the effects of surgical treatment on survival of 91 patients with metastatic primary breast cancer observed in the RCRC. NN Blokhin, for the period from 1999 to 2009. All women received systemic therapy with or without radiation therapy. Excision of the primary tumor was performed in 91 cases, in 106 cases (control group) the operation was not performed. Removal of the primary tumor in patients with primary - metastatic breast cancer with ECOG 0-1 has shown to be an independent prognostic factor, which significantly improves overall survival and progression-free survival. Multivariate analysis revealed a significant increase in overall survival and progression-free survival in those cases where the operation was carried out after successful systemic therapy with achievement of partial response, compared with those who underwent surgery in the first stage (p < 0,05). In addition, the long-term results of surgical treatment of patients with newly diagnosed metastatic breast cancer affect the number of metastases, the number of affected organs and positive hormone receptor status of the tumor (p < 0.05). However, given the many other factors that can affect the long-term results of surgical treatment of patients with primary metastatic breast cancer, it is advisable to conduct a prospective study.
MARKERS FOR THE EFFICIENCY OF BEVACIZUMAB THERAPY IN PATIENTS WITH DISSEMINATED COLON CARCINOMA
Authors: Fedyanin M. Yu. , Tryakin A. A. , Tyulyandin S. A.
Published: December 2023

Among the drugs with angiogenic mechanism of action, only bevacizumab demonstrates proved activity against colorectal cancer. However, tumor resistance develops during its treatment and a number of tumors seem to be primarily susceptive to bevacizumab. This review gives the results of investigations for finding the clinical, instrumental, and molecular factors predicting the efficacy of bevacizumab in patients mainly with disseminated colon carcinoma.
SIMULTANEOUS SURGERY FOR GASTRIC AND HEPATIC POLYNEOPLASIA
Authors: Chissov V. I. , Vashakmadze L. A. , Sidorov D. V. , Cheremisov V. V. , Khomyakov V. M. , Andrianov A. N.
Published: December 2023

The concurrence of gastric cancer and primary hepatic neoplasm ranks third in the structure of polyneoplasia associated with gastric cancer and accounts for 14.3%. Gastric tubular adenocarcinoma and hepatocellular carcinoma are predominant histological forms. In practice, the hepatic focal mass detected is generally interpreted as metastatic lesion, which frequently leads to unfounded refusal of radical treatment. At the same time, adequate preoperative examination with the obligatory histological verification of both a gastric tumor and a hepatic mass and the comparison of their morphological patterns permits one to make a correct diagnosis and to plan a potentially radical intervention for both nosological entities.
The influence of neutrophil elastase inhibitors on mice survival with the pancreatic cancer during experiment
Authors: Berezovsky I. V , Fokeev S. D.
Published: December 2023

Inhibitor neutrophil elastase (ZD0892) increases mice survival with the pancreatic cancer in experiment. This effect amplifies at application of ZD0892 with xelody (antimetabolite, antineoplastic drug, fluoropyrimidine carbamate derivative), which inhibits primary tumor growing in the pancreatic cancer.
A CASE OF EFFECTIVE COMBINATION TREATMENT FOR INTRACEREBRAL METASTASES FROM OVARIAN CANCER
Authors: Reshetov I. V. , Zaitsev A. M. , Filonenko E. V. , Kurzhupov M. I.
Published: December 2023

The described clinical case demonstrates the efficiency of combination treatment for intracerebral metastases, which involves surgical removal of metastasis with intraoperative fluorescence diagnosis and photodynamic therapy for the bed of a removed tumor, followed by brain radiation. The patient has been alive for 17 months since intracerebral metastases were detected.
PLACE OF DRUG THERAPY IN THE COMBINATION TREATMENT OF MALIGNANT OVARIAN GERM CELL TUMORS
Authors: Rusakov I. G. , Chernyshev I. V. , Kosov A. A.
Published: December 2023

The paper presents drug treatment options for malignant ovarian germ cell tumors in relation to their stage and histological type. It describes international clinical trials of chemotherapeutic agents and their comparative characteristics.
THE DATA OF DNA- FLOW CYTOMETRY IN PROGNOSIS OF CERVIX CANCER
Authors: Kravets O. A , Bogatyrev V. N
Published: December 2023

The purpose of research - the study of quantitative cell cervical cancer (CC) due to radiation therapy: ploidy and their distribution over the phases of the cell cycle analysis of the relationship of these parameters with clinical prognosis factors. Presents the group of 121 patients with CC II, III, IV stages, where the courses combined radiotherapy were from 2000 to 2008. Biopsy tumor samples were used during the radiotherapy. Diploid tumors were detected in 38 (31.4%) patients, aneuploid - in 75 (62%), tetraploid - in 7 (5.8%) and 1 (0.8%) - gyperaneuploid tumor. Overall and disease free-5-year survival in diploid tumors was higher (68,4 ± 9,6% and 45,1 ± 11,0%) compared to the aneuploid (45,4 ± 8,4% and 32.7 ± 7,2%), p
STATUS OF TRYPSIN PROTEINASES AND KININ SYSTEM IN CANCER TISSUE AND POLYPS OF THE COLON
Authors: Kit O. I , Frantsiyants Ye. M , Kozlova L. S , Terpugov A. L
Published: December 2023

Activity of trypsin-like proteinases and components of kinin system in the cancer tissue and polyps of sigmoid colon and rectum has been studied. Exhaustion of kinin system has been identified, as well as significant prevailing of activity of trypsin proteinases both in the malign tumor and in its resection line relative to the corresponding material of polyps. It has been concluded that the tissue surrounding a cancer cannot be considered healthy, even conditionally, at least within the affected organ. The studied parameters of polyps and surrounding healthy tissue maintained their physiological balance. The analysis performed proves that the main distinction of trypsin proteinases status and kinin system in the studied cancer tissue and polyps is the degree of their activation and efficiency of their interaction.
Effect of HER2-Neu expression in primary tumor on the efficacy of adjuvant polychemotherapy in patients with stage i-ii small cell lung cancer
Authors: Kolesnik A. P
Published: December 2023

Lung cancer is a "world leader" in structure incidence and mortality from malignant disease. Surgery is the main treatment that can completely treat patient. But, nearly 50% of patients had disease progression after operation due to presents of micro metastases in time of operation. That’s why necessary to indicate group of patients who needs adjuvant chemotherapy for increasing survival of patients. It is possible to indicate group of patients with the help of molecular markers. The aim of our study is to investigate effectiveness of adjuvant chemotherapy in early non-small cell lung cancer patients due to expression of HER2-Neu in primary tumor. Evaluation of HER2-Neu expression was conducted in 243 patients. HER2-Neu hyperexpression was detected in 70 (28,8%) patients, and absence of HER2-Neu expression in 173 patients (71,2%). We did not identify relationships between HER2-Neu expression in primary tumor and sex, age of patients, location, histologic form, morphologic differentiation of tumor, T criteria. However, patients with N1 and accordingly stage II more frequently defined HER2-Neu hyper expression (р=0,0001 and р=0,001). Moreover, decrease survival was defined in patients with early stages non-small cell lung cancer with HER2-Neu hyper expression in primary tumor (р
THE TREATMENT OF PATIENTS WITH SQUAMOUS CELL CARCINOMA OF SKIN IN HEAD AND NECK REGION
Authors: Pustynskiy I. N. , Kropotov M. A. , Tkachev S. I. , Paches A. I. , Alieva S. B. , Yagubov A. S. , Bazhutova G. A. , Slanina S. V.
Published: December 2023

In order to achieve the best aesthetic, functional and long-term results, the choice of treatment for patients with skin squamous cell carcinoma of the head and neck region should take into account the individual characteristics and the characteristics of the tumor, extent, location, growth forms. Based on these experimental studies the authors have developed a new way to treat patients with locally advanced squamous cell carcinoma of the skin, including a combined cryo-radiation effect on the tumor. Clinical approaches were developed and the indications were identified for choosing the optimal method of treatment for patients with squamous cell carcinoma of the head and neck skin with the use of various types of treatment: cryosurgical, surgical, combined, cryoradical. The treatment results of 76 patients with squamous cell carcinoma of the head and neck skin have been analyzed, using the developed approaches to the choice of treatment. Good long-term, aesthetic and functional results were noted in patients with early stages of the disease, and in locally advanced forms of tumors.
ULTRA-HIGH FREQUENCY RADIOTHERMAL MAMMOGRAPHY IN NEOADJUVANT BREAST CANCER THERAPY EFFECT EVALUATION
Authors: Sinelnikova O. A. , Kerimov R. A. , Sinyukova G. T. , Baranova Marina Petrovna
Published: December 2023

Ultra-high frequency radio thermal mammography permits thermal changes to be estimated both within the breast and onto its surface. Due to its simplicity, non-invasiveness and safety, decametric microwave radio-thermometry may be a promising method for diagnosing breast cancer and evaluating the efficiency of its treatment.
Isolated metastases in soft tissue of the chest wall in ovarian cancer: case report
Authors: Kolyadina I. V , Komov D. V , Cherkasova M. V , Khokhlova S. V , Orel N. F , Poddubnaya I. V
Published: December 2023

Case report of isolated metastatic soft tissue of the chest wall in a patient 45 years old with pretreated ovarian cancer. Relapse appeared 16 months later after primary treatment and was a solid tumor in the soft tissues of the chest wall, under the right breast tissue, was verified by cytology, morphology, immunohistochemistry and laboratory (increasing CA 125). The patient received the combination treatment: excision of metastasis and following chemotherapy in RCRC.
CLINICAL CASE OF SUCCESSFUL LONG-TERM TREATMENT OF THE PATIENT WITH METASTATIC CERVICAL CANCER
Authors: Bagrova S. G , Gorbunova V. A
Published: December 2023

Modern approach to individualization of the patients’ treatment, based on careful supervision over the minimum manifestations of an illness and competent combination of chemotherapy, target agents, radiotherapy allow to supervise a disease for a long time.
DIFFICULTIES IN THE DIAGNOSIS OF APPENDIX CANCER: A CLINICAL REPORT
Authors: Komov D. V , Kolyadina I. V , Polikarpova S. B , Mazurov S. T , Karasev I. A , Vasiljeva N. N
Published: December 2023

A clinical case of appendix cancer in 68-year-old woman, earlier operated for metastatic ovarian tumor is described. The professional diagnostic approach (immunohistochemical morphology and re-colonoscopy) could help identify appendix cancer and changed treatment algorithm for secondary radical surgery.
New method of jejunogastroplasty after gastroectomy during gastric cancer
Authors: Baryshev A. G , Khachaturyan N. V
Published: December 2023

The authors have developed a method of reservoir jejunogastroplasty after total gastroectomy during cancer of the stomach. The peculiarities of the digestive system function after total gastroectomy with various methods of esophagojejunostomy after lymphadenectomy D1, D2-3 were studied. The results show the advantages of jejunogastroplasty over standard variants of esofagoenterostomy.
CURRENT APPROACHES TO EVALUATING THE EFFICIENCY OF TREATMENT FOR REPRODUCTIVE TRACT TUMORS BY RECIST OR GCIG CRITERIA
Authors: Korneyeva I. A. , Novikova E. G. , Rubtsova N. A. , Moskovskaya E. Yu , Puzakov K. B.
Published: December 2023

The present communication discusses unified criteria for assessing the response evaluation criteria in solid tumors (RESIST) that are used to determine complete and partial responses, stabilization, and progression. It gives a classification of gynecological cancer intergroup (GCIG) criteria for elevated CA125 levels in patients with ovarian cancer after termination of primary therapy, which can determine the time of disease progression in patients having isolated growth of the marker during monitoring, without revealing tumor foci.
PARANEOPLASTIC LIMBIC ENCEPHALITIS IN NEUOROLOGICAL AND ONCOLOGICAL PRACTICE
Authors: Shnayder N. A , Dmitrenko D. V , Dykhno Yu. A , Ezhikova V. V
Published: December 2023

Paraneoplastic limbic encephalitis is a rare disorder characterized by personality changes, irritability, depression, seizures, memory loss and sometimes dementia. The diagnosis is difficult. Clinical symptoms are often lacking, and symptoms usually mimic other brain pathology. Early recognition of paraneoplastic limbic encephalitis and prompt intervention with immune therapies will probably translate into more favorable neurological outcomes.
MALIGNANT NEOPLASMS IN THE POPULATION OF BURYATIA REPUBLIC
Authors: Chimitdorzhieva T. N.
Published: December 2023

The anlysis of the malignant neoplasms morbidity in the Republic of Buryatia over a long period of time (25 years) without subdivision on location has been performed. From 1987 to 2011, a high growth of cancer pathology has been identified, which the author relates to unfavorable ecological environment, especially with the high background radiation in the Trans-Baikal region, due to bedrock, mountainous terrain, creating a so-called "hollows effect" and the presence of strong uranium, gold, ores and building materials. Based on the standardized indicators of the oncological morbidity for the last 10 years (2000-2010), the maps of the cancer pathology risk in the population of the administrative regions in the Republic of Buryatia for management and preventive measures for its prevention have been drawn. Pre-existing card as a result of morbidity external testing for the period (1996-2005) has undergone significant changes, indicating its significant growth.
PLEURAL MESOTHELIOMA: ETIOLOGY, INCIDENCE, DIAGNOSIS, TREATMENT AND SURVIVAL
Authors: Lazarev A. F , Grigoruk O. G , Bazulina L. M , Muzalevskiy P. N , Kravtsov V. Yu
Published: December 2023

The incidence rate of malignant pleural mesothelioma accounts for 0.2 cases per 100,000 population among men and 0.1 cases among women in Russia, and 0.88 and 0.67 cases respectively in Altai Territory. Recently, there has been a growing number of the incidences due to a widespread use of asbestos in the 70th years of the last century. Malignant mesothelioma is distinguished by a prolonged latency period, and constitutes a highly aggressive tumor. By now, the diagnosis of pleural mesothelioma still remains a problem. CT and US-scans are used together with chest X-ray. Morphological confirmation of tumor (biopsy and cytologic examination of exudation complemented by immunocytochemical technique) is obligatory. Treatment of malignant mesothelioma mostly includes chemotherapy with cisplatin and pemetrexed. Radical surgery is more frequently impossible considering a diffusion growth of mesothelioma. Radiotherapy is used as prevention, and applied to a puncture point and post-surgery to prevent local recurrence. The life expectancy of the patients with malignant pleural is poor: from 4 to 12 months with an average of 7 months. Only 26.5% of such patients have life expectancy longer than one year, and 6.8% of such patients live longer than 3 years. Maximum life expectancy of patients with malignant pleural mesothelioma accounts for 44 months. These are women with accumulation of fluid diagnosed in the left-sided pleural space with epithelioid mesothelioma.
CLINICAL SEMIOTICS AND SURGICAL PREOPERATIVE DIAGNOSIS OF STAGE-I BREAST CANCER
Authors: Kolyadina I. V , Komov D. V , Poddubnaya I. V , Danzanova T. Yu , Kostyakova L. A , Sinyukova G. T , Banov S. M
Published: December 2023

Screening tumors of breast are detected by instrumental methods of diagnosis, such as mammography (MG), ultrasonography (USG) and magnetic resonance imaging (MRI) only; typically have a size to 2.0 cm (T1) and need support (MG or USG control) at biopsy for morphological study. In the present study the clinical symptoms were analyzed using a large clinical data (1,347 patients with stage-I breast cancer), the rate of screening tumors and the possibility of pre-surgical biopsy of these tumors. The proportion of screening cancer, identified by instrumental methods of diagnosis was only 12.8%, which means the insufficient level of screening programs for all age groups women. Screening methods had the maximum diagnostic value in microcarcinomas (tumors less than 5 mm) which had no clinical symptoms and almost non-palpable. Young patients (
RADIATION DETECTION OF BREAST CANCER IN WOMEN WITH A GENETIC PREDISPOSITION OR FAMILY HISTORY (REVIEW)
Authors: Karpova M. S , Korzhenkova G. P , Lubchenco L. N , Dolgushin B. I
Published: December 2023

Screening of breast cancer with mammography recommended to women below the age of 40 years old has been shown to decrease mortality from breast cancer. But there is group of young women with high risk for developing breast cancer. The main part of this group are women with BRCA 1/2 mutations and women with strong family histories without known BRCA 1/2 mutations. Mammography has much lower accuracy in women under 40 years especially genetic mutation carriers compared to sporadic cases of breast cancer. For this reason there is necessity in new screening methods of young high-risk women to detect early-stage cancers.
Current approach es to the treatment of peritoneal pseudomyxoma of abdomen
Authors: Abdullaev A. G , Polotskiy B. E. , Davydov M. I
Published: December 2023

Pseudomyxoma of the peritoneum — a rare type of tumour progression of intra-abdominal localization, mainly of the appendix that is expressed in a diffuse mucinous carcinomatosis, regardless of the degree of differentiation of the primary tumour. Despite the long history of the effective treatments development, the prognosis of pseudomyxoma still remains unsatisfactory. The following paper provides an analysis of the literature on various aspects of the tumour genesis and the experience of the thoracic department in treatment of patients with peritoneal pseudomyxoma using original cytoreductive surgery and intraperitoneal hyperthermic himioperfuzii techniques, a detailed analysis of the immediate and long-term results of treatment.
Implex treatment of locally advanced oropharyngeal cancer
Authors: Manikhas G. M , Ostrinskaya T. V , Nuraev N. B , Zhumankulov A. M
Published: December 2023

This article compares different complex treatments combinations of locally advanced oropharyngeal cancer with the surgical component before and after radiation treatment. The authors compare the short-and long-term outcomes for patients with oropharyngeal cancer regimens: chemotherapy+ radiation therapy + surgery (CT+RT+S) and chemotherapy + surgery +radiation therapy (CT+ S +RT). The application of combined treatments with a surgical component of the first phase prior to radiation therapy (CT+ S +RT) has reduced the number of postoperative complications by 2 times and significantly reduce the time of the patient in the hospital and the length of tube feeding and the period of tracheostomy use in comparison with the scheme (CT+RT+S).
Morphofunctional characteristics of fibroblasts in peritumorous zone of renal cell carcinoma in different degrees of malignancy
Authors: Cherdantseva T. M , Bobrov I. P , Klimachev V. V , Bryuhanov V. M , Lazarev A. F , Avdalyan A. M , Dolgatov A. Yu , Samartsev N. S
Published: December 2023

Morphological and functional activity of fibroblasts in peritumorous zone (PZ) in renal cancer has been studied in 33 patients, using microspectrophotometrical, histological and histochemical methods. Activity of fibroblasts morphofunctional PZ depended on tumors ’ malignancy degree and was highest in most malignant tumors. Morphofunctional fibroblasts ’ activity correlated with width, degree of severity of sclerosis and neoangiogenesis of kidney cancer PZ.
Health care services use by patients who died from oncological diseases during the last year of their lives
Authors: Maltsev S. N
Published: December 2023

Medical aid appealability of 568 people who died from oncological diseases during the last year of their lives has been analysed. The investigated cohort consisted of 288 men, 280 women at the age from 24 to 94. The statistics of various medical aid appealability is mentioned below.
LIFE QUALITY OF PATIENTS WITH CERVICAL CANCER AFTER THE IMMUNOTHERAPY
Authors: Manambaeva Z. A , Lazarev A. F , Kenbaeva D. K , Medeubaev R. K , Mustafina B. K , Matyzina E. N
Published: December 2023

Research objective - definition of immunotherapy influence on quality of life in patients with cervical cancer in comparison with traditional antineoplastic therapy. 117 patients with cervical cancer, exposed to antineoplastic therapy by means of questionnaire SF-36 are surveyed. Patients were exposed to the complex therapy including specific and adoptive immunotherapy. Relative improvement of quality of life has been reached in group of immunotherapy application, statistically significant according to a number of SF-36 scales.
Pecularities of immunocytochemical reaction on cytokeratins application in the differential diagnosis of tumor and non-tumor pleurisy and ascites
Authors: Grigoruk O. G , Kravtsov V. Yu , Bazulina L. M , Lazarev A. F
Published: December 2023

The results of the immunocytochemilal reactions applications with cytokeratins 5/6, 7, 18, 20 and pan-cytokeratins from 81 patients are presented in this article. To evaluate the reaction it is necessary to take into consideration that mesothelial origin cells express both low and high molecular keratins. In differential diagnostics of adenocarcinoma and epiteliod mesothelioma as well as reactive mesothelium it is very important to evaluate immunoreactivity of cytokeratins and the result of reaction of mesothelial and epithelial markers.
CRYOSURGERY TREATMENT OF PATIENTS WITH BASAL CELL SKIN CARCINOMA II STAGES OF THE HEAD
Authors: Pustynskiy I. N. , Paches A. I. , Kropotov M. A.
Published: December 2023

Cryosurgery was used for treatment of 71 patients with basal-cell skin cancer of the head II stages in selective group according to the indications. Follow-up was from 2 to 11 years (med. 6 years). Recurrence rate after cryosurgery treatment was 5,6 %. Recurrent tumors were treated by cryosurgery (2) and surgery (2). Good esthetic and functional results were noted.
Family medullary thyroid cancer: etiology, pathogenesis, diagnosis
Authors: Yukina M. Yu , Troshina E. A , Beltsevich D. G , Rumyantsev P. O
Published: December 2023

Medullary thyroid cancer (MTC) represents 2-8 % of thyroid malignancies. Predominantly MTC have sporadic nature but 20-30% of cases are hereditary caused by germ line missense mutation in RET gene with autosomal dominant inheritance. There are precise genotype-phenotype correlations of RET mutation location (genotype) with tumor manifestation age, disease aggressiveness, presence of components of multiple endocrine neoplasia syndrome 2a and 2b types (phenotype). MTC is considering as slow-growing tumor but early metastasizing. Regional metastases frequently involve neck and mediastinal lymph nodes, distant — lungs, liver and bones. Calcitonin — highly sensitive biomarker of either primary or recurrent MTC.
DIAGNOSTIC POSSIBILITIES OF ORAL FLUID BIOMARKERS FOR TUMORS OF THE PAROTID
Authors: Kochurova E. M , Kozlov S. V , Nikolenko V. N , Gujter O. S
Published: December 2023

Tumors of maxillofacial area violate main physiological functions. Tumors of the parotid gland are common, but asymptomatic. After the treatment of these tumors long-term observation of the following is required. Currently a noninvasive method for early diagnosis of tumors of the parotid gland is not developed. In turn, the family of matrix proteinases are involved in the control of malignant tumors growth through metastasis and angiogenesis. This is confirmed in our study of the biomarkers level in oral fluid.