bluuebunny/crossref_metadata_2025 huggingface dataset:
Chaos and Reconfiguration of Space: How Can a Sense of Belonging in a Fluid Space Be Achieved? — The Innovative Exploration of Mobile Vendors’ Management in Jixiang District
Authors: Zhou Wenxiu
Published: July 2024

Street vendors are a common phenomenon in cities and a difficult point in urban management. More and more city administrators have realized that instead of banning and driving away street vendors, it is better to integrate them into the city’s regular management, making them a means to benefit the public, improve people’s livelihood, and promote economic vitality. The appearance of street vendors is a true reflection of residents’ needs. The case of managing street vendors jointly by the City Administration Bureau of Jixiang District, Jibei Street Office, and volunteer veteran forces exemplifies the new era of city administrators’ commitment to people-oriented governance and flexible law enforcement. This includes their attempt to use flexible governance measures to achieve innovative exploration in the spatial management of city street vendors. It is a model for current grassroots social governance innovation and can provide reference and inspiration for the current management of city street vendors.
Application of Constructed Wetlands to Treat Sewage by the Government in China
Authors: Tang Jiayao
Published: July 2024

This study examines the deployment of constructed wetlands in China, focusing on their efficacy in water purification and ecological restoration, with a case study on the city of Wuxi. Constructed wetlands, which utilize natural processes to treat wastewater, represent a sustainable alternative to conventional methods. Despite their benefits in enhancing water quality and local biodiversity, these systems pose significant challenges, notably in land use and socio-economic impacts. The research highlights the conflict between environmental initiatives and urban development, exacerbated by land scarcity and housing affordability issues. This paper proposes strategies for optimizing wetland design and suggests policy adjustments to balance ecological benefits with urban development needs, aiming for sustainable urban planning.
Manejo de la hipertensión arterial. Actualización
Authors: Figueroa García Grimanesa del Rocío , Pacheco Ramos Zoila María , Estupiñan Vera Jose Luis , Aguilar Miranda Steeven Alejandro
Published: July 2024

La HTA es el principal factor relacionado con la mortalidad en todo el mundo. Las cifras de presión aumentan progresivamente con la edad, por lo que la prevalencia de HTA depende extraordinariamente del segmento etario analizado. Se llevó a cabo una revisión exhaustiva de la literatura médica existente, abarcando estudios clínicos, revisiones sistemáticas y guías de práctica clínica. La metodología incluyó la evaluación crítica de la evidencia disponible. Se destacó la importancia de un enfoque integral que combine cambios en el estilo de vida, como la dieta saludable y el ejercicio regular, con la utilización de una variedad de medicamentos antihipertensivos, adaptados a las necesidades individuales de los pacientes. Se concluyó que el manejo óptimo de la hipertensión arterial requiere una colaboración estrecha entre pacientes y profesionales de la salud, con un énfasis en la adherencia al tratamiento a largo plazo y el seguimiento regular para lograr resultados clínicos favorables y reducir el riesgo de complicaciones cardiovasculares.
Concomitant Ozaki procedure and septal myectomy in patients with severe aortic stenosis
Authors: Kobzev E. E. , Karpov I. A. , Rosseikin E. V.
Published: July 2024

Objective. The presence of marked asymmetric septal hypertrophy in patients with aortic stenosis may lead to dynamic obstruction of the left ventricular outflow tract in addition to fixed obstruction at the level of the aortic valve. The persistence of an increased subvalvular gradient may worsen both early and long-term results. At the same time, surgical tactics in combination of two pathologies is currently undefined.

Aim: To analyze the early and mid-term results of concomitant Ozaki procedure and septal myectomy.

Patients and Methods. This case series included 13 patients with severe aortic stenosis and asymmetric septal hypertrophy who underwent aortic valve reconstruction according to the Ozaki technique and septal myectomy according to Morrow. The mean age was 68 years [from 50 to 79]. In 12 of 13 patients, the aortic valve annulus was less than 21 mm. Early and mid-term (29.5 months) clinical results, complications specific for septal myectomy, hemodynamic parameters at the aortic valve and left ventricular outflow tract were evaluated.

Results. 1 patient died at the hospitalization stage. There were no cases of repeated aortic clamping for aortic valve prosthesis, additional resection of interventricular septum, acute defect of interventricular septum. One patient required permanent pacing due to complete transverse heart block. There were no lethal outcomes during the follow-up. Good hemodynamic results were achieved in all patients: mean aortic valve area 2.2 cm2 (from 1.4 to 3.0 cm2 ); mean transvalvular gradient 11 mmHg (from 6 to 15 mmHg); basal interventricular septum thickness 11.2 mm, left ventricular outflow tract gradient 3.9 mmHg.

Conclusion. In our case series of 13 patients with aortic stenosis and subvalvular left ventricular outflow tract obstruction, Ozaki procedure and septal myectomy resulted in good early and mid-term clinical and hemodynamic outcomes. Septal myectomy is a safe procedure without increasing the risk of complications. However, large prospective randomized comparative studies are needed to provide reliable evidence of the benefit of combined intervention and to develop optimal recommendations.
The role of consultative conversations with psychoemotional correction in patients after endovascular occlusion of open foramen ovale
Authors: Tuchik E. S. , Tereshchenko A. S. , Ivanenko T. A. , Merkulov E. V.
Published: July 2024

The article discusses aspects of the restoration of the psychoemotional sphere in patients suffering a stroke associated with an open foramen ovale, who underwent endovascular occlusion at the stationary stage. It was revealed that due to their negative social perceptions of the recovery of patients after a stroke, they are afraid to return to an active lifestyle after treatment. The possibility of introducing consultative conversations with psychoemotional correction to create a positive social way of life for patients after a stroke, which will contribute to the restoration of their psychoemotional sphere, is considered.
Tendencies and features of cerebral stroke mortality according to the data of Tomsk Regional Vascular Center
Authors: Alifirova V. M. , Boykov V. A. , Plotnikov D. M. , Naydenova N. E. , Nagaitsev A. V. , Protasova L. M. , Stasyuk N. A. , Amonotidi A. V. , Shirykalov G. M. , Dmitrieva Y. S.
Published: July 2024

Introduction. In Tomsk Region specialized medical care for the patients with acute cerebrovascular disorders has been provided and coordinated since 2012 by the Regional Vascular Center of Tomsk Regional Clinical Hospital where more than three-quarters of all stroke patients in the region are admitted annually.

Aim: To study the dynamics of mortality rates in different nosological forms of stroke, gender and age characteristics of the patients who died from stroke, the example of the work of the Regional Vascular Center of Tomsk Regional Clinical Hospital being used, and to determine the directions for further improvement of medical care organization.

Materials and Methods. At the first stage, the assessment of the dynamics of mortality rates from different nosological forms of stroke in Tomsk Regional Clinical Hospital according to the Federal Statistical Observation Form No. 14 from 2018 to 2022 was performed. At the second stage of the study, based on data from registration form No. 066/u of the Regional Vascular Center, the structure of gender and age of the patients who died from stroke was analyzed, the average age of death of the patients with stroke, their gender and age characteristics, taking into account the form of stroke, were determined.

Results. Mortality rates from stroke in Tomsk Regional Clinical Hospital were relatively stable and quite high – 23.6–24.8%; the greatest fluctuations in mortality rates (36.0–59.6%) and (46.7–56.9%) were observed in hemorrhagic forms. The average age of death from stroke in men at the Regional Vascular Center was 12 years lower than in women – 67.0 (59.0–76.0) years. Distinct gender differences were revealed among deceased patients with a significant predominance of men – 73.0 and 68.6% in the age groups 18–44 years and 45–59 years.

Conclusion. Directions for further improvement of medical care organization have been identified: opening an additional vascular center, developing mechanisms for timely re-evacuation of patients, optimizing the system for managing stroke risk factors.
Transcatheter aortic valve implantation in patients with bicuspid aortic valve (literature review)
Authors: Mkrtychev D. S. , Komlev A. E. , Kolegaev A. S. , Imaev T. E.
Published: July 2024

Transcatheter aortic valve implantation (TAVI) is a technology that allows effective surgical treatment for aortic valve stenosis. One of the causes of aortic stenosis is a congenital pathology characterized by a bicuspidal structure of the aortic valve. This condition has long been considered an absolute contraindication to TAVI, however, the emergence of new generations of prostheses, surgical experience, as well as a deep understanding of the anatomy of bicuspid valves allows to perform TAVI in such patients. This article discusses the existing classifications of bicuspid aortic valves, the features of preoperative preparation, and also presents the results of existing studies of TAVI in patients with bicuspid morphology.
Artificial intelligence methods in cardiovascular surgery and diagnosis of pathology of the aorta and aortic valve (literature review)
Authors: Kim G. I. , Blekanov I. S. , Ezhov F. V. , Kovalenko L. A. , Larin E. S. , Razumilov E. S. , Pugin K. V. , Dadashov M. S. , Pyagay V. A. , Shmatov D. V.
Published: July 2024

The management of patients with aortic and aortic valve pathology is an extremely relevant task. The main problem of this pathology is the absence of obvious symptoms before the onset of a life–threatening condition, dissection or rupture of the aorta. Early timely diagnosis becomes the most relevant in this situation, and imaging research methods play a leading role in this regard. However, the main limiting factor is the speed and quality of image evaluation. Therefore, an actual task is to develop an AI-based physician assistant for image mining (Computer vision, CV). This article provides an overview of modern neural network methods for effective analysis of diagnostic images (MSCT and MRI) relevant for the study of diseases of the cardiovascular system in general and the aorta in particular. One of the main focuses of this analysis is the study of the applicability of modern neural network methods based on the Transformer architecture or the Attention Mechanism, which show high accuracy rates in solving a wide range of tasks in other subject areas, and have a high potential of applicability for qualitative analysis of diagnostic images. An overview of two fundamental problems of image mining is given: classification (ResNet architecture, ViT architect, Swin Transformer architect) and semantic segmentation (2D approaches – U-Net, TransUNet, Swin-Unet, Segmenter and 3D approaches – 3D-Unet, Swin UNETR, VT-UNET). The described methods, with proper fine tuning and the right approach to their training, will effectively automate the process of diagnosing aortic and aortic valve pathology. For the successful implementation of AI development projects, a number of limitations should be taken into account: a high-quality data set, server graphics stations with powerful graphics cards, an interdisciplinary expert group, prepared scenarios for testing in conditions close to real ones.
Mid-term hemodynamic results of bioprosthetics of the aortic valve with a prosthesis with a unique “easy change” system
Authors: Ergashev Sh. S. , Petlin K. A. , Alyamkin V. E. , Chernykh Y. N. , Kozlov B. N.
Published: July 2024

Aim: To assess the hemodynamic results of using the xenopericardial biological prosthesis “MedEng-BIO” with the “easy change” system in the aortic position in the mid-term period.

Material and Methods. In the cardiac surgery department No. 1 of Cardiology Research Institute, Tomsk NRMC, from October 2016 to January 2024, 341 patients (155 women and 186 men) underwent aortic valve replacement surgery using an innovative “MedEng-BIO” bioprosthesis with the “easy change” system. The average age of the patients was 67.6 ± 6.6 years. The study included 190 patients (88 women and 102 men) who underwent aortic valve replacement using the innovative “MedEng-BIO” bioprosthesis with the “easy change” system in the period from January 2017 to January 2022. The average age of the patients was 67.6 ± 6.6 years. The average pressure gradient on the aortic valve before surgery was 48.2 ± 13.5 mmHg. The effective area of the aortic valve opening averaged (EАO) – 0.72 ± 0.2 cm2 . Control echocardiographic studies of left ventricular (LV) function and aortic bioprosthesis after surgery were performed on the 10th–14th day after surgery and 3–5 years after discharge using Vivid 7, GE and IE 33 (Philips) devices.

Results. Control echocardiographic studies conducted in the mid-term period allowed us to establish that the hemodynamic characteristics of “MedEng-BIO” aortic prostheses in the aortic position remain satisfactory. The average pressure gradient on the “MedEng-BIO” prostheses of 21 sizes was 22.6 mmHg, 23 with a size of – 15.1 mmHg and 25 with a size of 10.3 mmHg.

Conclusion. Based on the data obtained, it can be concluded that xenopericardial “MedEng-BIO” bioprostheses with the “easy change” system correct intracardiac hemodynamics well over a follow-up period of more than 3 years and show no signs of degeneration.
Repair and reinforcement of masonry (restoration of continuity) in conditions of negative temperatures
Authors: Shevchenko Maxim , Reshetnikov Sergey , Kostenko Alexander
Published: July 2024

The article deals with the problem of defects in load-bearing exterior brick walls. In many facilities with brick walls, after several years of operation, defects such as vertical cracks in the masonry and the destruction of the bricks of the front layer begin to appear. These defects reduce the bearing capacity of the building and can lead to the collapse of individual sections of the brick cladding layer, worsen the aesthetic appearance of the building, as well as reduce the thermal characteristics of the exterior walls. This problem is considered on the example of the building of a warm parking lot for cars of the administrative complex of Gazprom Dobycha Yamburg LLC, located in the Far North, in Novy Urengoy. The building was put into operation in 2005. As of 2023, non-penetrating cracks were found in the front layer of the brickwork in some areas, which is recorded in the technical report based on the results of the technical condition survey. The article presents the data obtained during the survey carried out in 2023. The main defects of the outer lining layer of load-bearing walls are described, among which are non-penetrating cracks in the front layer of masonry in the humidification areas, shrinkage non-penetrating cracks in the front layer of masonry, efflorescence, hollowing (incomplete filling of the masonry seam), individual destroyed bricks of the front layer. The main reasons for the formation of cracks in the outer brick walls and the destruction of individual bricks of the front layer are the wetting of the wall surface in the corners of the masonry, water penetration at the junctions of the parapet slats, as well as shrinkage of the building. The article considers two possible methods of repairing the above defects, which formed the basis of the working documentation – the traditional method, as well as an alternative method of structural repair, which allows performing the necessary work in conditions of negative temperatures, based on the use of a system of spiral anchors.
Biotransformation and removal of sulfur from dibenzothiophene using improved biocatalytic methods
Authors: MOGOLLÓN L. I. , LAROTTA C. E. , MORA A. L. , MADERO A.
Published: July 2024

Three methods for the removal of sulfurfrom dibenzothiophene were evaluated using biocatalytic processes. The methods were a microbial, an enzymatic and a combined one that involves a previous enzymatic oxidation followed by microbial degradation. The byconversion was evaluated over the molecular dibenzothiophene model, obtaining higher byconversion percentages through the combined method. The microorganisms used in this study correspond to several Colombian indigenous strains isolated by direct methods from natural sources, and using a standard strain as positive control. All strains have shown sulfur removal capacity, and organic solvent tolerance. The enzyme used was a hemoprotein with peroxidase activity, Cytochrome C, obtained from equine heart.
PENGARUH CAPITAL STRUCTURE, TANGIBLE ASSETS, INTANGIBLE ASSETS, DAN SALES GROWTH TERHADAP NILAI PERUSAHAAN DENGAN KINERJA KEUANGAN SEBAGAI VARIABEL INTERVENING (Studi Empiris Pada Perusahaan Properties dan Real Estate Yang Terdaftar di Bursa Efek Indonesia)
Authors: Ananda Mira Febriana Ananda , Triyono Triyono
Published: July 2024

Company value is very important because it reflects financial performance which can influence investors' assessments. Investors really need stock assessments when deciding to invest. Financial performance is an effort that can be made by each company to measure and predict the success achieved by the company when making a profit. This research examines the influence of capital structure, tangible assets, intangible assets, and sales growth on company value with financial performance as an intervening variable. The population in this study are companies listed on the Indonesia Stock Exchange in 2020-2022. The sample in this research is Properties and Real Estate Companies listed on the Indonesia Stock Exchange in 2020-2022. Based on the purposive sampling method, 156 samples were obtained that met the specified criteria. The type of data used is secondary data. The hypothesis in this study was tested using the latent variable correlation test. Based on the results of the latent variable correlation test, this research concludes that intangible assets have an effect on financial performance; intangible assets influence company value; and financial performance influences company value.
EXPLORING THE KALAMKARI THROUGH HAND-PAINTED TEXTILE ART
Authors: Gollapalle Preethi , Kota Dileep Kumar , Kumar Rajesh
Published: July 2024

Indian calligraphy, or kalamkari, is a highly regarded traditional art form whose elaborate hand-painted motifs on textiles have attracted art fans for years. This paper delves into the intricate world of Kalamkari, a traditional Indian art form celebrated for its hand-painted textile artworks. The study aims to uncover Kalamkari's historical evolution, cultural significance, and contemporary relevance through a multidimensional exploration. The methodology combines a thorough literature review, field study, visual analysis of artworks, and comparative examination across regions and historical periods. The literature review provides insights into Kalamkari's origins, techniques, and socio-cultural contexts, while field study involves interactions with artisans and documentation of their techniques and processes. Visual analysis scrutinizes motifs, colours, and narrative elements in Kalamkari textiles, illuminating their aesthetic and symbolic dimensions.
Tantangan menuju pendidikan unggul: membangkitkan produktivitas institusi pendidikan untuk kualitas pendidikan yang lebih baik di Indonesia
Authors: Faridli Efi Miftah , Abidin Nurul , Sutama Sutama , Sutopo Anam , Murtiyasa Budi
Published: July 2024

Penelitian ini menyoroti pentingnya investasi dalam pelatihan guru sebagai kunci peningkatan kinerja akademik siswa. Penelitian ini menggunakan metode campuran (mixed method). Hasil penelitian menunjukkan bahwa dengan pelatihan berkala, guru mengalami peningkatan kompetensi dalam metode pengajaran, yang secara langsung berdampak pada minat dan pemahaman siswa. Analisis regresi dari data sekolah yang menerapkan program pelatihan guru menunjukkan peningkatan rata-rata 15% dalam skor tes siswa selama dua tahun. Ini menunjukkan bahwa pendekatan interaktif dan inovatif dalam pengajaran, yang diperkuat melalui pelatihan, menciptakan lingkungan belajar yang efektif dan menarik. Selain itu, penelitian ini mengeksplorasi implementasi kurikulum yang disesuaikan dengan kebutuhan industri kontemporer, yang meningkatkan keterampilan praktis siswa sebesar 25% dalam teknologi dan komunikasi. Kurikulum yang relevan ini juga meningkatkan keterlibatan dan motivasi belajar siswa, dengan peningkatan partisipasi aktif di kelas sebesar 30%. Penelitian ini juga menunjukkan peningkatan keterampilan berpikir kritis dan kreatif siswa sebesar 35%, menghasilkan siswa yang tidak hanya lebih baik dalam prestasi akademis tetapi juga lebih inovatif dan adaptif. Namun, penelitian ini menghadapi beberapa keterbatasan, seperti fokus pada jumlah terbatas sekolah dan ketergantungan pada metode kuantitatif yang mungkin tidak sepenuhnya menangkap nuansa pengalaman individual siswa dan guru. Implementasi metode pengajaran baru ini juga memerlukan sumber daya tambahan dan pelatihan guru yang intensif, menunjukkan perlunya investasi dan perencanaan yang lebih besar dalam sistem pendidikan untuk mengadopsi pendekatan ini secara luas.
Development of cognitive behavior counseling guidebook with bibliocounseling techniques to improve junior high school student academic motivation
Authors: Idayanti Ni Luh , Dantes Nyoman , Gading I Ketut , Dharsana I Ketut , Suranata Kadek
Published: July 2024

Learning motivation greatly affects student success in receiving lessons and greatly impacts the improvement of student learning outcomes. This study aims to produce a guidebook design, determine the validity of the content, know the practicality, and test the effectiveness of cognitive behavior counseling guidebooks with bibliocounseling techniques to increase the motivation to learn junior high school students. The method used is research and development (research and development) with a 4D model (Four D) developed by Thiagarajan (1974) which is limited to content validation testing. Three experts and five counselling guidance practitioners were involved to assess the feasibility of the guidebook. Test the validity of the contents of the guidebook using the content validity ratio (CVR) and content validity index (CVI) of Lawshe (1975). The analytical technique used to test the effectiveness of cognitive behavior counseling guidebooks with bibliocounseling techniques to increase student learning motivation is using Posttest – Only Control Group Design. The design of this shape uses a comparison, grouping is done randomly and no pre-test is held. The results of this study show that (1) produce cognitive behavior counseling guidebooks with bibliocounseling techniques to increase the motivation to learn junior high school students. (2) The results of the CVR analysis obtained a value of 24.7 and a CVI value of 0.88, this shows that the guidebook is valid. (3) The practical test of the guidebook on the assessment of 5 guidance and counseling practitioners obtained an average score of 89% (practical), which means that this guidebook is practical for use by guidance and counseling teachers. (4) The effectiveness of the guidebook obtained the values of the experimental group and the control group Sig. (2-tailed) 0.000 < 0.05. Based on these results, it can be concluded that the implementation of cognitive behavior counseling guidebooks with bibliocounseling techniques is effective in increasing the motivation to learn junior high school students.
Use of game-based educational entertainment media to foster mathematical problem-solving proficiency in pre-service mathematics teachers
Authors: Yulia Romadiastri , Mujiasih Mujiasih , Ardani Riska Ayu , Setambah Mohd Afifi Bahurudin
Published: July 2024

The capacity to solve mathematical problems is an essential component of the professional abilities that pre-service instructors of mathematics are required to possess. When it comes to coping with technological advancements in the sphere of education, this skill serves as the foundation. For the purpose of enhancing one's capacity to solve mathematical problems, this study proposes an innovative method that involves the use of game-based educational entertainment media (GEM). Within the realm of development research, this research technique focuses on the ways in which problem-solving skills can be enhanced by participation in activities that are based on game-based entertainment media. The ADDIE phases—analysis, design, development, implementation, and evaluation—are the steps that are utilised in the process of development. The GEM was utilised by 94 pre-service mathematics teachers who participated in this research. GEM is effective in developing mathematical problem-solving skills, according to the findings of the research. This is accomplished by encouraging pre-service mathematics teachers to identify problems, model them, solve problems mathematically, and assess the results of their efforts.
Implementasi integrasi nilai-nilai moderasi beragama dalam intrakurikuler keagamaan di madrasah tsanawiyah
Authors: Nuhaliza Siti , Asari Hasan , Dahlan Zaini
Published: July 2024

Moderasi beragama adalah cara pandang dan cara bersikap tegas dalam menyikapi dan menghargai perbedaan agama, serta perbedaan ras, suku, budaya, dan adat istiadat guna menjaga persatuan antar umat beragama dan mampu menjaga keutuhan Negara Kesatuan Republik Indonesia. Indonesia. Oleh karena itu, penerapan nilai-nilai moderasi beragama yang diterapkan di Madrasah Tsanawiyah Negeri 3 Langkat mampu memberikan dan menerapkan nilai-nilai moderasi beragama yang mana tidak ada diskriminasi antara satu sama lain dan dapat saling menghargai dan menghormati. Yang bertujuan untuk menjaga persatuan antarbangsa, menjalin toleransi terhadap perbedaan di kalangan umat Islam, membentuk sikap kemanusiaan dan membangun sikap saling menghargai dan menghargai demi terciptanya perdamaian dan keharmonisan antara satu sama lain, serta saling mengenal di tengah perbedaan. mulai dari budaya, suku. ras dan lain-lain sehingga membentuk suatu kesatuan yang utuh. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan studi kasus, dengan melakukan wawancara kepada kepala sekolah, Wkm Kurikulum, guru Pai, dan siswa. Hasil atau temuan dari penelitian ini adalah MTs N 3 langkah sudah menerapkan nilai-nilai moderasi beragama yang sudah masuk dalam kurikulum sehingga terbiasa menerapkan nilai-nilai moderasi beragama yang meliputi saling menghargai dan menghargai satu sama lain dan tidak melakukan diskriminasi satu sama lain. satu sama lain di tengah banyak perbedaan.
Media Sosial Sebagai Media Pelayanan Informasi Perguruan Tinggi
Authors: Fadli Rohmad , Navratilofa Martina , Puspitasari Yopa
Published: July 2024

Artikel ini membahas terkait media sosial sebagai media pelayanan informasi perguruan tinggi. Tujuan dari penelitian ini adalah untuk mengetahui media sosial yang digunakan humas UIN Fatmawati Sukarno Bengkulu sebagai Perguruan Tinggi Keagamaan Islam Negeri dibawah naungan Kementerian Agama sebagai media pelayanan informasi. Metode penelitian yang digunakan adalam field research (penelitian lapangan). Informan penelitian ini adalah redaktur dan admin pengelola media sosial resmi UIN Fatmawati Sukarno Bengkulu. Hasil penelitian ini yaitu Humas UIN Fatmawati Sukarno Bengkulu melakukan fungsinya sebagai humas perguruan tinggi, antara lain : memberikan pelayanan informasi public melalui media sosial (instagram, youtube dan fanspage facebook) dan pusat pelayanan informasi dan dokumentasi serta menajalin hubungan dengan berbagai media (media relations). Serta Pengelola media sosial (instagram, youtube dan fanspage facebook) sebagai media pelayanan informasi publik yang dikelola oleh humas UIN Fatmawati Sukarno Bengkulu cukup efektif dalam menjaga saluran informasi instansi dengan publik. Terbukti dengan diraihnya peringkat ke 2 webomatric Perguruan Tinggi seProvinsi Bengkulu.
Penerapan Teknik Clustering Berbantuan Media Nearpod dalam Meningkatkan Keterampilan Menulis Teks Deskripsi
Authors: Pratomo Berliana Permatasari , Utami Sintowati Rini , Lestari Lita
Published: July 2024

Keterampilan menulis teks deskripsi merupakan salah satu kompetensi dasar yang harus dikuasai oleh siswa kelas VII SMP. Penelitian ini bertujuan untuk mengkaji penerapan teknik clustering berbantuan media Nearpod dalam meningkatkan keterampilan menulis teks deskripsi siswa kelas VII SMP Labschool Jakarta. Penelitian ini menggunakan metode penelitian tindakan kelas (PTK) dengan tiga siklus. Subjek penelitian adalah 34 siswa kelas VII-C SMP Labschool Jakarta. Teknik pengumpulan data yang digunakan adalah tes, observasi, dan wawancara. Hasil penelitian menunjukkan bahwa penerapan teknik clustering berbantuan media Nearpod dapat meningkatkan keterampilan menulis teks deskripsi siswa kelas VII-C SMP Labschool Jakarta. Hal ini ditunjukkan oleh peningkatan nilai menulis teks deskripsi siswa dari 66,4 pada siklus I, 75,4 pada siklus II, dan 88,9 pada siklus III. Selain itu, hasil observasi menunjukkan bahwa siswa menjadi lebih aktif dan kreatif dalam menulis teks deskripsi. Berdasarkan hasil penelitian, dapat disimpulkan bahwa teknik clustering berbantuan media Nearpod merupakan salah satu strategi pembelajaran yang efektif untuk meningkatkan keterampilan menulis teks deskripsi siswa.
Bentuk Kohesi Gramatikal dan Leksikal dalam Wacana Informatif Cuitan Akun Sosial Media X @KAI121
Authors: Erisa Faridatul Maghfiroh  , Atiqa Sabardila, M.Hum.
Published: July 2024

Penelitian ini digunakan untuk menyelidiki dan mengupas bentuk kohesi gramatikal dan leksikal akun sosial media Twitter atau X @KAI121 pada kurun waktu September 2023. Penjelasan deskriptif memberi pemahaman dari data yang ditelisik secara kualitatif. Keseluruhan data yang didapat sebanyak 63 data unggahan selanjutnya dianlisis hingga menemukan kohesi gramatikal sebanyak 9 dan leksikal sebanyak 18 data. Penelitian ini menggunakan metode simak dengan teknik catat. Perupa data diperoleh dari hasil menyimak bahasa untaian kata-kata dalam alineanya. Bahasa wujud teks yang diteliti merupakan objek yang menjadi alasan pemilihan metode simak. Selanjutnya teknik catat untuk mencatat hasil dari bahan teks simakan. Hasil dari data yang telah dianalisis diuraikan dalam bentuk bahasa tulis termuat pada artikel ini. Penyajian data diproyeksikan melalui tabel guna mempermudah pemahaman terhadap pembaca dan peneliti selanjutnya. Hasil yang diperoleh diperjelas menggunakan bahasa ulasan pada tiap cuitan yang mula terdapat di tabel, tetap dilengapi dengan bahasan. Data yang diperoleh separuh dari total data yang dianalisis memiliki bentuk kohesi leksikal atau gramatikal. Untuk memudahkan pembaca peneliti juga menyertakan bentuk tangkapan layar serta kutipan yang memiliki bentuk kohesi.
Implementasi Kurikulum Merdeka pada Pembelajaran Bahasa Indonesia Kelas X di SMK Negeri 1 Sedayu
Authors: Rohmah Azizah Nuzulul , Esti Swatika Sari
Published: July 2024

SMK Negeri 1 Sedayu merupakan salah satu SMK Pusat Keunggulan di Daerah Istimewa Yogyakarta yang mengimplementasikan Kurikulum Merdeka. Tujuan penelitian ini, yaitu mendeskripsikan dan menjelaskan (1) perencanaan, (2) implementasi, serta (3) kendala dan upaya yang dilakukan oleh pendidik mata pelajaran Bahasa Indonesia dalam mengimplementasikan Kurikulum Merdeka pada pembelajaran Bahasa Indonesia kelas X di SMK Negeri 1 Sedayu. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Hasil dari penelitian ini menunjukkan bahwa (1) perencanaan Kurikulum Merdeka telah dilakukan dengan adanya modul ajar yang mengacu pada Capaian Pembelajaran Bahasa Indonesia Fase E, (2) implementasi Kurikulum Merdeka dilihat dari aspek materi, model, media, dan penilaian pembelajaran yang digunakan sudah sesuai dengan perencanaan pembelajaran meskipun terdapat unsur-unsur dalam modul ajar yang terlewat tidak dilaksanakan, (3) terdapat dua kendala yang ditemukan, serta (4) upaya-upaya dilakukan oleh pendidik untuk mengatasinya.
Kata Kunci: implementasi kurikulum, kelas X, Kurikulum Merdeka, pembelajaran Bahasa Indonesia, SMK.
Application of therapeutic nucleic acids and RNA interference to create products for personalised medicine
Authors: Shilovskiy I. P. , Pasikhov G. B. , Smirnov V. V. , Kofiadi I. A. , Popova M. V. , Strueva P. A. , Khaitov M. R.
Published: July 2024

INTRODUCTION. Small interfering RNAs (siRNAs) are among the most promising types of therapeutic nucleic acids aiming at the inhibition of pathogenetically relevant gene expression through the RNA interference mechanism. However, the limited bioavailability and immunogenicity of siRNAs and imperfect delivery systems hinder the clinical potential and applicability of siRNA medicinal products.AIM. This study aimed to summarise recent advances in the development of siRNA medicinal products and the corresponding delivery systems, review clinical trial results, and outline future development prospects for these medicinal products.DISCUSSION. This article covers the molecular mechanisms underlying RNA interference, the considerations for siRNA development, and the techniques for effective siRNA delivery. The article dwells upon various systems for nucleic acid delivery to targeted cells. The most promising delivery systems are non-viral systems, including liposomes, exosomes, nanoparticles, polymers, cell-penetrating peptides, and GalNAc ligands. Their main advantages include their ease of complexation with nucleic acids, modification and functionalization potential, favourable safety profile, ability to cross biological barriers, and tropism to target tissues. The article summarises the information that has accumulated over the past few years in clinical trials of siRNA medicinal products for a range of conditions, including metabolic disorders, infections, and cancers, as well as hereditary, ophthalmic, renal, and hepatic diseases. Special attention is paid to siRNA medicinal products undergoing clinical trials (over 10 products) and approved for clinical use (6 products, including MIR 19, the first authorised Russian siRNA medicinal product).CONCLUSION. Ultimately, siRNA medicinal products are a promising tool for personalised medicine, exhibiting therapeutic potential for a wide range of pathological conditions. Further studies of siRNA medicinal products should aim at improving siRNA production technology to increase their bioavailability and half-life period. In addition, these studies should aim at enhancing delivery systems for these products to mitigate toxicity risks and maximise efficacy.
Experience in the production and clinical application of the cell-based medicinal product Easytense® for the repair of cartilage defects of the human knee
Authors: Zoricheva A. S. , Zvonova E. A. , Agapova L. S. , Lykova M. S. , Markova O. A. , Leonov V. S.
Published: July 2024

INTRODUCTION. The current cell-based cartilage repair methods, such as autologous chondrocyte transplantation, are not sufficiently effective, and the surgery is painful and traumatic. Therefore, there is a need for a more effective cell therapy product with a minimally invasive surgical procedure for its implantation into the patient.AIM. This study aimed to develop a manufacturing technology for the production of an autologous cell-based medicinal product (CBMP) comprising three-dimensional structures (3D-spheroids) based on chondrocytes isolated from the patient’s cartilage tissue, as well as to evaluate its clinical efficacy.MATERIALS AND METHODS. Autologous chondrocytes isolated from the patient’s cartilage biopsy were propagated in monolayer culture to obtain the required number of cells. Subsequently, the chondrocytes were cultivated on plates with a non-adhesive coating to form 3D spheroids. All CBMP production steps were performed under aseptic conditions in cell culture isolators. The authors used phase-contrast microscopy and immunohistochemical staining with specific fluorescence-labelled antibodies to characterise chondrocyte phenotypes at different stages of cultivation. Genetic stability was controlled by karyotyping. The efficacy of Easytense® was evaluated in a clinical trial using specialised functional tests and the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. The primary efficacy endpoint was a change in the overall score on the Knee Injury and Osteoarthritis Outcome Score (KOOS).RESULTS. A manufacturing technology without using animal sera, growth factors, cytokines, or other additives was developed for the production of the autologous CBMP Easytense®. Karyological data confirmed that the chondrocytes retained genetic stability for 3 passages in monolayer culture. When cultured as 3D spheroids, the chondrocytes produced cartilage extracellular matrix proteins (type II collagen, aggrecan), thus acquiring the ability to repair damaged cartilage. The clinical trial demonstrated a statistically significant improvement in knee cartilage 12 months after the transplantation of 3D spheroids derived from autologous chondrocytes. The mean change in the overall KOOS score was 23.8±15.9.CONCLUSIONS. The clinical trial results indicate that Easytense® is highly effective for cartilage repair. Based on these results, the CBMP has been granted marketing authorisation and introduced into clinical practice in the Russian Federation. Easytense® has the potential to replace endoprosthetics and expensive surgeries abroad.
The First World War of 1914–1918 in the fate of the Balkan peoples
Authors: Iskenderov Petr
Published: July 2024

The article is devoted to the significance of the First World War in the history of the peoples of the Balkan Peninsula. The author focuses on the relationship between the Balkan countries and the great powers, primarily Russia. Unpublished archival documents are used in the article.
Humans vs GPTs: Bias and validity in hiring decisions
Authors: Lippens Louis
Published: July 2024

The advent of large language models (LLMs) may reshape hiring in the labour market. This paper investigates how generative pre-trained transformers (GPTs)—i.e. OpenAI’s GPT-3.5, GPT-4, and GPT-4o—can aid hiring decisions. In a direct comparison between humans and GPTs on an identical hiring task, I show that GPTs tend to select candidates more liberally than humans but exhibit less ethnic bias. GPT-4 even slightly favours certain ethnic minorities. While LLMs may complement humans in hiring by making a (relatively extensive) pre-selection of job candidates, the findings suggest that they may miss-select due to a lack of contextual understanding and may reproduce pre-trained human bias at scale.
POLITICAL-ECONOMIC NETWORKS AND SOCIAL MOBILIZATION OF THE BAZAARIS IN THE PERSIAN SPRING 2009
Authors: Bakhtiar Ramadhan Reza , Burdah Ibnu , Yunus Masrukhin Mohammad
Published: July 2024

This article examines the involvement and role of bazaaris in the Persian Spring from 2009 to 2011. As economic actors, these bazaaris participated in political activities that opposed Ahmadinejad’s victory in the Iranian presidential election. This rejection sparked mass mobilization, fueled by religious fervor, political and social ideologies, and economic concerns. The qualitative research approach employed in this study utilizes political sociology, drawing data from literature reviews and digital fieldwork. The data analysis conducted in this research employs the theory of conflict and mass mobilization, yielding two significant findings. First, it reveals that the political-economic network of bazaaris is cross-border and multi-dimensional. Second, it highlights that the mass mobilization of bazaaris against Ahmadinejad is primarily motivated by political and economic competition. Consequently, the findings of this study contribute to enriching the discourse of political sociology, particularly in conceptualizing popular resistance movements against authorities based on political-economic conflicts. These conflicts are intricately woven into the fabric of magnetic field politics, which tend to be transactional in nature.
La politique mémorielle du régime Orbán en Hongrie ou la misère d’un petit État
Authors: Horel Catherine
Published: July 2024

Dans un pays très clivé politiquement, ce sont les événements tragiques qui sont mis en avant. Le mélange de complaisance et de refoulement nourrit le syndrome victimaire, érigeant la souffrance en valeur suprême. Les Hongrois sont très productifs en la matière grâce à leur tradition insurrectionnelle qui génère de nombreux martyrs dont la mémoire se transmet de génération en génération. Le panthéon national est soumis aux ruptures de la continuité historique qui muent les héros de la veille en traîtres et vice-versa. Ce mouvement erratique se traduit depuis la fin du XIXe siècle par la création de lieux de mémoire dont l’inflation récente révèle la difficulté à produire un consensus sur la définition de la nation hongroise. À travers eux, la nation acquiert une dimension symbolique. Mais la population n’est pas dupe des travestissements historiques opérés par les régimes successifs.
De la démocratie autoritaire, en France et ailleurs
Authors: Ory Pascal
Published: July 2024

L’assimilation du démocratique au libéral est une théorie que l’Histoire dément, depuis, au moins, l’Antiquité grecque des « tyrans ». Les Modernes confirment, après cinq siècles d’expérimentation politique : la Souveraineté du « Peuple » a produit un type d’idéologie (populiste) et deux types d’institutions (la démocratie autoritaire et la démocratie totalitaire) qui, aujourd’hui, dominent la majorité des « peuples ».
The State of Europe, 2024: A Chronicle
Authors: Goldhammer Arthur
Published: July 2024

Europe in 2024 faces major challenges in the areas of security, immigration, the economy, and the environment. The war in Ukraine and the uncertain direction of the foreign policy of the United States signal that the European Union is about to embark upon a new historical era. Meanwhile, nationalist feeling is increasing in most member states, as political party systems shift rightward in response to populist pressures. The paper analyzes these changes and inventories the range of policy responses across Europe.
Ambivalent Democracies. Uses and Misuses of Tocqueville Within the Abolitionist Debate (1839–1865)
Authors: Guerini Anna
Published: July 2024

In this essay, I investigate the ways in which abolitionists and pro-slavery forces use Tocqueville before and during the Civil War, drawing on the major black and white abolitionist newspapers ( The Liberator, National Anti-Slavery Standard, The National Era, The North Star, and The Colored American). By focusing on the dissemination of Tocqueville’s ideas within a specific audience of white abolitionists, and on the impact of blacks’ criticism on this process, I challenge Tocqueville’s abolitionist arguments. Thus, using Tocqueville as a prism through which to discuss some of the key issues surrounding the abolitionist struggles, I show that the author’s reception depends on the relevance of these struggles and claims for the definition of democracy itself as an endless and potentially unmanageable process.
ON THE ISSUE OF LEGAL RESPONSIBILITY IN MODERN RUSSIAN LAW
Authors: EPIFANOVA E.V. ,   Kuban State University, KOSTIN A.A. ,   Kuban State University
Published: July 2024

This work is devoted to the study of the main trends in the development of legal liability in the Russian Federation. The authors presented the main provisions on the formation and development of legal responsibility, starting with the Ancient Russian state, as well as the current state of this legal category. As a result of a retrospective analysis, the article concludes about the main directions of the development of legal responsibility: changing the goals, types and forms of legal responsibility, combining methods of legal influence, improving the mechanism of legal responsibility. In the article, these trends are justified by the complication of public relations, the development of science, and the influence of socially and state significant events. A reasoned assumption is made that the reforms in the system of legal responsibility are aimed at achieving the goals and objectives of the rule of law.
LEGAL STATUS OF PERSONS WITH IMPLANTABLE CYBER-PHYSICAL SYSTEMS
Authors: ERTEL L.A. ,   Kuban State University, MKHITARYAN A.V. ,   Kuban State University
Published: July 2024

In the process of developing and introducing high-tech systems into medicine, a dilemma arises in terms of determining the danger of their use and possible influence on the will, mind and consciousness of a person. The article analyzes the essence of autonomous and non-autonomous cyberphysical systems, identifies and discloses possible mechanisms of the impact of implantable high-tech systems on human personality and behavior. The article also examines the theoretical problems of bringing to criminal and administrative responsibility the manufacturers of these systems and third parties hacking their software for the actions of a person who committed a crime or offense under the influence of cyberphysical systems. In the course of the research, legal gaps in criminal and administrative tort law in this area of knowledge were identified and the need to eliminate them was established.
THE UKRAINIAN LANGUAGE AS A LINGUISTIC AND CULTURAL PHENOMENON AND EDUCATIONAL STRATEGY ON THE COLUMNS OF THE SCIENTIFIC JOURNAL "NATIVE LAND" (1905–1916)
Authors: Stepanenko N
Published: July 2024

Thearticle is devoted to the analysis of the political, economic literary and scientific journal «Ridnyi Krai» («Native Land») (1905-1916) through the prism of linguistic, sociolinguistic, linguistic and cultural, and partly educational problems with a special emphasis, firstly, on the change of the political situation in Ukraine in the early twentieth century and the reflection of this progress in various spheres of public life, and secondly, on the role of the Ukrainian language as the most important ethnic identifier. The linguistic, sociolinguistic, linguistic cultural, educational content of the weekly is elucidated, in particular, the range of problems raised on its pages is revealed, followed by their classification and ideological, professional, cultural, didactic, axiological interpretation from synchronic and diachronic positions. The specifics of the evolution of the vernacular and literary language in different periods are characterized in detail, based on the linguistic practice of Taras Shevchenko Marko Vovchok and other classics of Ukrainian literature and its comparison with the linguistic experience of an ordinary peasant,and the interaction between the specific resource and borrowings. Particular attention is paid to the sociolinguistic aspect i.e., views on the language of the city and the countryside, and the role of various educational institutions in shaping national consciousness. It has been proved that the publication “Ridnyi Krai”, with which the significant figures of the time, primarily Olena Pchilka, Hryhorii Kovalenko, Mykola Dmytriiev, Agatangel Krymskyi, and Borys Hrinchenko, associated their activities, had a significant impact on the development of the Ukrainian issue, which came after long official bans on the Ukrainian word; on the development of literary norms, primarily spelling, which are rightly considered a powerful unifying factor of the Ukrainian nation; on the expansion of functional capabilities (scientific, journalistic, and artistic spheres) of the Ukrainian language, and ultimately on its nation-building potential. The linguistic, cultural, educational, and other views, ideas, and beliefs declared or substantiated in the works of various genres published in the «Ridnyi Krai» found a logical continuation, and most of them have not lost their relevance to this day.