bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMBELAJARAN MATEMATIKA STRATEGI QUANTUM LEARNING UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA
Authors: Sukamto Sukamto
Published: June 2018

This study in the background backs low student motivation, especially elementary school mathematics subject matter. Mathematics courses is one of the lessons learned from the primary school level. Even informally parents have taught mathematics to the toddler through the tools of play. Elementary students have thought of mathematics courses is subject scary and considered difficult. Mathematics courses are eye pelajarana considered difficult for students, student motivation to learn a low, monotonous learning process, uninteresting and boring for students. Students in participating in math do not wholeheartedly and only keterpaksaaan alone. Conditions like these that lead to low mathematics achievement.One of the characteristics of mathematics is to have an abstract object and became one of the difficulties faced by both teachers to teach and students in understanding it. Teachers as educators should be aware that elementary school students still think concretely. This causes the teacher should try to reduce the abstract nature of mathematical objects so as to facilitate the students understand the subject matter, but still directed towards the achievement of learning abstract thinking ability of students. Elementary school students still think concretely, it is easy to understand if it can be detected by the senses. Learning strategies should be able to maximize all potential, every student has the same right to succeed. All the elements that underpin the success of learning should be mixed into an accumulation that really create a learning atmosphere. Some of the techniques used is to give positive suggestions with seats the students are comfortable, put background music in the classroom, increasing the participation of individuals, using posters to give a great impression while highlight information (DePorter, 2005: 14). Thus we can conclude quantum mathematics learning strategy learning can increase students' motivation.
Dengue serosurvey after a 2-month long outbreak in Nîmes, France, 2015: was there more than met the eye?
Authors: Succo Tiphanie , Noël Harold , Nikolay Birgit , Maquart Marianne , Cochet Amandine , Leparc-Goffart Isabelle , Catelinois Olivier , Salje Henrik , Pelat Camille , de Crouy-Chanel Perrine , de Valk Henriette , Cauchemez Simon , Rousseau Cyril
Published: June 2018

Background

Clusters of dengue cases have recently become more frequent in areas of southern France colonised by the vector mosquito Aedes albopictus. In July 2015, a 2-month outbreak of dengue virus serotype 1 (DENV-1) was reported in Nîmes. Aim: We conducted a serosurvey in the affected area at the end of the vector activity period to determine the true extent of dengue transmission. Methods: We collected capillary blood from consenting household members, and information on their medical and travel histories, and exposure to mosquito bites. Recent infections were identified using IgM and IgG anti-DENV ELISA, followed, when positive, by plaque reduction neutralisation tests on serum against DENV 1–4 and West Nile virus. The prevalence estimator was calibrated on reference demographic data. We quantified the spatial clustering of dengue cases within the affected community and inferred the transmission tree. Results: The study participation rate was 39% (564/1,431). Three of 564 participants tested positive for DENV-1 infection (after marginal calibration, 0.41%; 95% confidence interval: 0.00–0.84). The spatial analysis showed that cases were clustered at the household level. Most participants perceived the presence of mosquitos as abundant (83%) and reported frequent mosquito bites (57%). We incidentally identified six past West Nile virus infections (0.9%; 95% CI: 0.2–1.6). Conclusion: This serosurvey confirms the potential for arboviral diseases to cause outbreaks − albeit limited for now − in France and Europe.
Effects of Professional Development and Videoconferencing on the Increase of Opportunities to Respond and the On-Task Behavior of Students with Emotional Behavior Disorders
Authors: L Carmouche Millicent , L Thompson Jelisa , S Carter LaTiegra
Published: June 2018

Aim/Purpose: This study explored an alternative means to offering supervisory coaching to teachers, professional development, and virtual teacher coaching through the use of videoconferencing.

Background: Teacher coaching has been identified as an effective way to improve teacher implementation of research proven effective classroom strategies. The use of technology to implement coaching widens the audience of coaches that one coach can reach.

Methodology : A single-case multiple baseline design was used to investigate the effect the intervention had on the frequency with which teachers offer Opportunities to Respond (OTR) and on the on-task behavior of middle school students with emotional/ behavior disorders (E/BD).

Contribution: This paper expands the body of knowledge on teacher coaching to include the use of technology.

Findings: Results indicated there was a functional relationship between virtual teacher coaching with videoconferencing and teacher rates of OTR. However, no functional relationship was observed between teachers given OTR and student on-task behavior.

Recommendations for Practitioners : The use of technology to implement coaching widens the audience of coaches that one coach can reach.

Recommendation for Researchers: Future researchers should consider collecting data on academic information such as the number of correct responses in addition to on-task behavior.

Impact on Society : Teacher practitioners will be able to benefit from increased access to coaches, improving effective implementation of evidence-based practices.

Future Research: Among other things, researchers could consider studying students with disabilities other than emotional/behavioral disorders and even students without disabilities may give important information on how opportunities to respond works with other populations.
Peremajaan Kelapa Sawit (Elaeis guineensis Jacq.) di Seruyan Estate, Minamas Plantation Group, Seruyan, Kalimantan Tengah
Authors: Wibowo Wisnu Hari , Junaedi Ahmad
Published: June 2018

Kegiatan penelitian ini dilaksanakan di Seruyan Estate dari Februari hingga Juni 2016. Kegiatan magang ini bertujuan untuk mempelajari aspek teknis dan manajerial peremajaan kelapa sawit dan menganalisis kesesuaiannya dengan kriteria RSPO dan ISPO saat kegiatan replanting. Pengamatan yang dilakukan meliputi tahap-tahap peremajaan yang tepat berdasarkan standar yang telah ditetapkan perusahaan, prestasi kerja alat, dan prestasi kerja karyawan. Hasil pengamatan tersebut kemudian dianalisis secara deskriptif berdasarkan standar yang berlaku pada kegiatan peremajaan. Hasil pengamatan menunjukkan bahwa tahap peremajaan dibagi menjadi dua tahap, yaitu tahap persiapan lahan yang meliputi sensus pokok, pancang rumpuk, penumbangan, pencincangan, merumpuk pokok, deboling, tutup lubang deboling, pembuatan jalan kontur; dan tahap penanaman yang meliputi pemancangan titik tanam, penanaman kacangan penutup tanah, pembuatan lubang tanam, dan penanaman tanaman kelapa sawit. Seruyan Estate telah memenuhi kriteria RSPO dan ISPO dikarenakan adanya kewajiban mengelola area Nilai Konservasi Tinggi di dalam kebun. Selain itu, kegiatan peremajaan di Seruyan Estate juga tidak menggunakan api saat melakukan persiapan lahan.
IMPLIKATUR KAMPANYE POLITIK DALAM KAIN RENTANG DI RUANG PUBLIK
Authors: Handono Suryo
Published: June 2018

Kampanye politik merupakan komunikasi yang terencana untuk membentuk suatu citra yang diharapkan oleh penutur. Tuturan dalam komunikasi itu terdapat maksud yang tersurat dan tersirat atau disebut implikatur. Penelitian ini mengkaji implikatur dan sumber implikatur kampanye politik dalam kain rentang di ruang publik. Penyediaan data dilakukan menggunakan metode simak dengan teknik catat dan rekam. Melalui analisis pragmatik dengan metode padan terungkap bahwa dalam kampanye politik terdapat implikatur konvensional dan konversasional. Implikatur konversasional yang timbul adalah meyakinkan, mengajak, meminta, menjanjikan dan memerintah. Implikatur tersebut bersumber pada penerapan prinsip kerja sama dan prinsip kesantunan. Penerapan prinsip kerja sama meliputi pemenuhan dan pelanggaran maksim kuantitas, kualitas, relevansi, dan cara. Kemudian, penerapan prinsip kesantunan meliputi pemenuhan maksim ketimbangrasaan serta pelanggaran maksim ketimbangrasaan, kemurahhatian, dan kerendahhatian.
INTERPERSONAL METADISCOURSE MARKERS AS PERSUASIVE STRATEGIES IN BARACK OBAMA’S 2012 CAMPAIGN SPEECHES
Authors: Sukma Bayu Permana
Published: June 2018

One of language features which can be applied to reach the persuasive goal is interpersonal metadiscourse. Although it has been frequently investigated in written texts, research on interpersonal metadiscourse in campaign speeches is still relatively hard to find, whereas a lot of features of interpersonal metadiscourse in campaign speeches are used as persuasive strategies. This study aims to explain the meaning of interpersonal metadiscourse markers applied in Barack Obama’s campaign speeches related to his persuasive strategy. The data are analyzed by using Dafouz’s (2008) theory of interpersonal metadiscourse markers categorization. The method used in this study is descriptive qualitative. The results reveal that all interpersonal metadiscourse markers categories, namely hedges, certainty markers, attributors, attitude markers, and commentaries, are used in Barack Obama’s campaign speeches. High frequency of use of attitude markers and commentaries shows that Obama in his campaign speeches tries to build emotional ties with his audience as his persuasive strategy.
Application of Liquid Chromatography with Fluorimetric Detection for the Determination of Urinary Pentosidine in Type 2 Diabetes Mellitus Patients: Effect of Telmisartan Administration on Podocyturia and Relationship with Metabolic Control
Authors: Kornhauser Carlos , Barbosa-Sabanero Gloria , Gutierrez-Romero Noemí , Sabanero Myrna , Perez-Luque Elva L. , Gómez-Ojeda Armando
Published: June 2018

The beneficial effects of a short period of Telmisartan administration were successfully assessed trough pentosidine urinary levels (uPen) and urinary podocyte excretion (UPE), in type 2 diabetes mellitus (DM2) patients. Patients with podocyturia received Telmisartan treatment (80 mg/day) for two months.  uPen were quantified pre and post treatment using HPLC with fluorimetric detection and in-lab synthesized standard. Immunofluorescence method for podocalyxin was used to evaluate urinary excretion of podocytes. uPen and UPE significantly decrease after treatment (p<0.01255 and p<0.005 respectively), as well as serum total cholesterol and LDL levels (p<0.001). These results suggest that podocyte protection by Telmisartan even in the face of deficient metabolic control could be an important matter in the prevention and progression of diabetic nephropathy. This study also strengthens evidence of the promising role of pentosidine as prognostic and diagnostic markers in diabetic nephropathy
Application of Molecular Mass Spectrometry for The Structural Characterization of a DNA-Protein Cross-Links
Authors: Gong Jiawei , Solivio Morwena Jane , Merino Edward J , Landero Figueroa Julio Alberto
Published: June 2018

To date, many different analytical methods have been used to investigate the cross-linking reaction mechanism and to obtain the chemical structure of DNA-Protein Cross-links (DPCs). Direct MS analysis of DPCs is challenging because of the ionization properties of DNA and the protein. However, peptide sequencing and mass spectrometry (MS) as analytical techniques are playing increasingly important roles for the structure determination of DPCs model. In our previous study, a novel approach was presented for purification, detection and quantification of DPCs by newly developed inductively coupled plasma mass spectrometry (ICPMS/MS), which allows sub-ppb detection of S and P, key heteroelements in DNA and proteins.

In this study, we enhanced our previously developed method and it was complemented by the use of molecular MS to allow complete characterization of a DNA-protein cross-link.  First, a small molecule model is utilized to identify the adduct structure that will likely occur in an intact DNA-protein cross-link.  We investigate the thermal stability of DNA-protein cross-links, both in an intact DPC and a small molecule adduct to determine feasibility of digestion/thermal degradationof DNA without the cross-link information being lost.  Thermal degradation was conducted to reduce the cross-linked DNA into a single nucleoside. The remaining protein-nucleoside adduct then was proteolytically digested, generating a peptide-nucleoside adduct. The absence of the phosphate moiety allows for facile structural characterization via electrospray ionization mass spectrometry (ESI-MS).  Additional calculations were done for peptide matching allowing us to determine the cross-link location in the protein, made possible via MS/MS analysis.  Additionally, we show that steric effects play an important role in DPC formation.
Identification by MALDI-TOF MS of Environmental Bacteria with High Potential to Degrade Pyrene
Authors: Silva-Jiménez Hortencia , Araujo-Palomares Cynthia Lizzeth , Macías-Zamora José Vinicio , Ramírez-Álvarez Nancy , García-Lara Bianey , Corrales-Escobosa Alma Rosa
Published: June 2018

An alternative to remove polycyclic aromatic hydrocarbons (PAHs) of the environment is using hydrocarbonoclastic bacteria. The aim of this work was to study the bacterial diversity of indigenous isolates with potential to degrade pyrene. We used MALDI-Biotyper (Bruker Daltonics) as a powerful analytical tool for identification. Bacteria were isolated from surface seawater and marine sediments samples of three sites from the coast of Rosarito Port, B.C., Mexico. Total concentration of PAHs in collected samples was quantified by GC-MS, showed values ranged 0.461-0.525 ng mL-1 and of 74 -266 ng g-1 in seawater and sediments samples, respectively. A total of 52 bacteria with capacity to grow in 25 mg L-1 pyrene as sole carbon and energy source were taxonomically identified and classified by MALDI-Biotyper system by comparing the mass spectra with library and/or to use chemometric tools as Principal Components Analysis (PCA) and Composite Correlation Index (CCI) to evaluate possible differences to isolate level. The identified isolates were represented by three phylogenetic groups: Firmicutes, Actinobacteria and Proteobacteria. Of these isolates, Kocuria strains appear to be excellent candidates to continue PAHs degradation studies.
Molecular Modeling and Chiral Separation of Benzodiazepines by Capillary Electrophoresis Using Highly Sulfated Cyclodextrins
Authors: Vargas Martinez María Gabriela , Ramírez Galicia Guillermo
Published: June 2018

A capillary electrophoretic method for the chiral separation of the 3-chiral-1,4-benzodiazepines was developed. Enantiomeric resolution of oxazepam, lorazepam, temazepam, and lormetazepam was achieved using sulfated cyclodextrins (CD's) as chiral selectors. A 3-levels, 4-factors fractional factorial (34-2) design was applied to test 3 different CD's: heptakis-6-sulfato--cyclodextrin (HSCD), heptakis-(2,3-diacetyl-6-sulfato)--cyclodextrin (HDASCD), and heptakis-(2,3-dimethyl-6-sulfato)--cyclodextrin (HDMSCD). The CD type, its concentration, the pH of the electrolyte, and % organic modifier were tested as the factors in the experimental design. The highest resolution values were obtained using a 20 mM borate buffer, pH 9.0 with the addition of 5 % HSCD and 15 % methanol as an organic modifier. At these separation conditions, the equilibrium constants of the benzodiazepine-HSCD complex formation were calculated. A theoretical study of the interaction benzodiazepine-HSCD complex using semiempirical calculations is postulated.
Square Wave Anodic Stripping Voltammetry Determination of Arsenic (III) onto Carbon Electrodes by Means of Co-deposition with Silver
Authors: Méndez Cortés Sandra Perla , Galán Vidal Carlos Andrés , Rodríguez Ávila José Antonio , Álvarez Romero Giaan Arturo , Páez Hernández María Elena
Published: June 2018

In the present study an electrochemical assay for the detection of arsenic (III) by means of square wave anodic stripping voltammetry with co-deposition of silver at screen printed and glassy carbon electrodes is presented. This methodology shows a good behavior in presence of dissolved oxygen with appropriate detection limits to monitoring the water quality according to the guidelines values. The evaluation of most important interfering ions (Cl-, Hg2+, Pb2+ and Cu2+) is also described. The proposed analytical strategy demonstrated to be suitable for decentralized arsenic analysis and can be easily integrated to portable instrumentation commercially available.
Evaluation of Polydimethylsiloxane-Phenylsiloxane as a Coating for Stir Bar Sorptive Extraction
Authors: Pérez-Padilla Yamile , Medina Cetina Saúl Ariel , Ávila-Ortega Alejandro , Barrón-Zambrano Jesús Alberto , Vilchis-Néstor Alfredo Rafael , Carrera-Figueiras Cristian , Muñoz Rodríguez David
Published: June 2018

Analytical pretreatment has become environmental-friendly because of material science assistance. In stir bar sorptive extraction (SBSE), a coating is typically used to isolate and preconcentrate organic compounds in aqueous samples. Here, a translucent coating based on polydimethylsiloxane and phenyltriethoxysilane was prepared by a sol-gel method. Characterization tests showed that the coating was homogeneous, relatively polar, and both thermally (< 400 °C) and chemically stable. Coated stir bars were evaluated in the SBSE experiments. Benzene derivatives were successfully extracted/preconcentrated from aqueous solutions and environmental waters. Furanic derivatives and antibiotics were moderately extracted from water, but they were extracted from isooctane.
The Importance of Analytical Chemistry in Environmental Geochemistry Studies in Mexico
Authors: Armienta Maria Aurora
Published: June 2018

This review presents environmental geochemistry studies developed in Mexico involving analytical chemistry applied to marine, lake, lagoon, dam, and fluvial sediments, soils, and groundwater over the past 15 years. The paper summarizes the objectives of the research, the analytical methods that were used, the methodologies applied for the interpretation of the results, and the primary findings for the areas and specific substrates that were studied. Although diverse analytical techniques were applied, atomic absorption spectrometry was the primary method of analysis, followed by inductively coupled plasma atomic emission spectroscopy. Studies are widespread in the Mexican territory although some areas are still lacking in information; in addition, most of the country’s contamination problems have yet to be remediated.
Evidence for an additive effect of hunting mortality in an alpine black grouse Lyrurus tetrix population
Authors: Zbinden Niklaus , Salvioni Marco , Korner‐Nievergelt Fränzi , Keller Verena
Published: June 2018

In the Canton of Ticino in southern Switzerland data from the monitoring programme for black grouse from 1981 to 2016 (population density, lek size, sex ratio in chicks and adults) were analysed together with information on bag statistics and hunting regulations to evaluate if mortality from hunting had an additive effect. In the study population the proportion of cocks at the beginning of the study period was only 23%. As hunting regulations for black grouse were tightened in the late 1970s the observed proportion of males showed an increase in particular during the first years but remained much lower than what would be expected from the sex ratio among chicks assuming equal survival between the sexes. The observed low proportion of adult males indicates a lower survival rate and as a consequence a smaller than natural lek size. High reproductive success two years before had a positive effect on lek size. The correlation coefficient between hunting bag and population size index increased with increasing hunting pressure and showed a decline over the years. Bag size in the period with a high hunting pressure (1981–1999, many hunting days) was driven by population density whereas in the second period (2000–2016, few hunting days) it was driven by hunting regulations. Our analysis showed that hunting affects population structure and presents indirect evidence that mortality due to hunting is additive. The study also shows that hunting management has to be continuously adapted to changes in the size and structure of the population as well as changes in habitat conditions. It is therefore essential to continue long‐term monitoring of population size and of demographic parameters.
Водорастворимая форма 1-алкил(арил)имидазол-4,5-дикарбоновых кислот. особенности строения и противосудорожная активность триэтаноламмониевой соли 1-пропилимидазол-4,5-дикарбоновой кислоты
Authors: Брусина Мария Александровна , Николаев Дмитрий Николаевич , Фундаменский Владимир Семенович , Гуржий Владислав Владимирович , Золотарев Андрей Анатольевич , Селитреников Алексей Васильевич , Зевацкий Юрий Эдуардович , Потапкин Александр Михайлович , Рамш Станислав Михайлович , Пиотровский Левон Борисович
Published: June 2018

Получены водорастворимые формы для ряда 1-алкил(арил)имидазол-4,5-дикарбоновых кислот. Проведено исследование противосудорожной активности 1-пропилимидазол-4,5-дикарбоновой кислоты и ее триэтаноламмониевой соли на модели NMDA-индуцированных судорог. Показано, что триэтаноламмониевая соль 1-пропилимидазол-4,5-дикарбоновой кислоты обладает противосудорожным действием, в то время как сама кислота — судорожным. Изменение фармакологического профиля вещества связано с образованием ионных пар или ассоциатов, существующих даже в полярной физиологической среде. Способность к ассоциации подтверждена кондуктометрическим методом. Структура соли 1-пропилимидазол-4,5-дикарбоновой кислоты с триэтаноламином установлена методом РСА.
Синтез и туберкулостатическая активность 2-алкил-5-арилтетразолов
Authors: Ишметова Рашида Иршотовна , Толщина Светлана Геннадьевна , Игнатенко Нина Константиновна , Кравченко Марионелла Анатольевна , Скорняков Сергей Николаевич , Русинов Геннадий Леонидович , Чарушин Валерий Николаевич
Published: June 2018

С использованием реакций алкилирования и Манниха синтезированы 2-замещенные производные 5-арилтетразолов, содержащие алкильные и аминоалкильные фрагменты. Исследована туберкулостатическая активность синтезированных соединений в отношении штамма M. tuberculosis H37Rv. Выявлена выраженная туберкулостатическая активность (MIC ≤ 1,5 мкг/мл) тетразолов, содержащих при N(2) диметил- и диэтиламиноэтильные фрагменты.
Синтез и антипролиферативная активность конъюгатов даунорубицина с сесквитерпеновыми лактонами
Authors: Аникина Лада Владимировна , Семаков Алексей Владимирович , Афанасьева Светлана Васильевна , Пухов Сергей Александрович , Клочков Сергей Георгиевич
Published: June 2018

Проведена модификация антрациклинового антибиотика даунорубицина сесквитерпеновыми лактонами Inula helenium L. — алантолактоном, изоалантолактоном и аллоалантолактоном. Антипролиферативные свойства полученных конъюгатов изучены на опухолевых и нормальных клеточных линиях. Установлено, что конъюгат даунорубицина с алантолактоном на ряде культур опухолевых клеток обладает более выраженными антипролиферативными свойствами, чем даунорубицин, без увеличения токсичности по отношению к нормальным клеткам.
Разработка и валидация экспресс-методики выделения и количественного определения водорастворимых полисахаридов корней одуванчика лекарственного (Taraxacum officinale Wigg.)
Authors: Дьякова Нина Алексеевна , Сливкин Алексей Иванович , Самылина Ирина Александровна , Гапонов Сергей Петрович , Мындра Анна Андреевна , Шушунова Татьяна Геннадьевна
Published: June 2018

Разработана экспрессная методика выделения и количественного определения водорастворимых полисахаридов в корнях одуванчика лекарственного (Taraxacum officinale Wigg.), которая позволяет сократить затрачиваемое на нее время до 3,5 ч. Разработанная методика валидирована по показателям повторяемости, правильности, устойчивости и линейности, в результате чего доказано, что она прецизионна в условиях повторяемости, правильна, устойчива и обладает достаточно жёсткой линейной зависимостью массы осадка от массы анализируемого сырья при гравиметрическом определении водорастворимых полисахаридов в корнях одуванчика лекарственного. Методика может быть использована для экспрессного анализа качества корней одуванчика лекарственного, а также при промышленном получении инулина из данного вида сырья.
Вазопрессорные свойства ингибитора синтаз оксида азота соединения T1059. Сообщение I. Синтез, токсичность, NOS-ингибирующая активность, гемодинамические эффекты при нормотензии
Authors: Филимонова Марина Владимировна , Шевченко Л. И. , Макарчук В. М. , Чеснакова Е. А. , Суринова В. И. , Шевчук А. С. , Филимонов А. С. , Крыжановский С. А. , Шевченко Т. Ф. , Бугрова А. Е. , Каламкаров Г. Р.
Published: June 2018

Установлено, что соединение T1059 (гидробромид 1-циклогексанкарбонил-2-этилизотиомочевины) является водорастворимым, умеренно токсичным веществом (ЛД16, ЛД50 внутрибрюшинно — 274, 380 мг/кг), способным к конкурентному ингибированию активности синтаз оксида азота со значительной селективностью к индуцибельной и эндотелиальной изоформам NOS (ИК50 для nNOS, iNOS, eNOS — 60,3, 1,8, 3,2 мкмоль). При однократном внутрибрюшинном введении (в диапазоне доз 10 – 30 мг/кг) соединение T1059 быстро абсорбируется и распределяется в тканях, вызывая в них выраженное подавление эндогенной продукции NO. В дозе 10 мг/кг у нормотензивных наркотизированных крыс линии Wistar соединение T1059 оказывает длительное сосудосуживающее действие. Наблюдаемые изменения сосудистого тонуса не влияют на инотропную функцию сердца, но при этом сопровождаются незначительной брадикардией.
Синтез и биологическая активность хлоридов 1-хлорметил- и 1-дихлорметил-3,3-диалкил-3,4-дигидроизохинолиния
Authors: Михайловский Александр Георгиевич , Гашкова Оксана Владиславовна , Рудакова Ирина Павловна , Чащина Светлана Викторовна , Юсов Алексей Сергеевич
Published: June 2018

Циклоконденсацией диалкилбензилкарбинолов с хлорацетонитрилом или дихлорацетонитрилом синтезированы соответствующие 1-хлорметил- и 1-дихлорметил-3,3-диалкил-3,4-дигидроизохинолины. Гидрохлориды полученных соединений были испытаны на антиаритмическое, противосудорожное и анальгетическое действие. Водорастворимые гидрохлориды 1-хлорметилизохинолинов показали антиаритмическую активность, наибольший антиаритмический индекс 14,8. Эти же соединения активны в отношении коразоловых судорог. Анальгетический эффект 1-дихлорметилизохинолинов оказался на уровне метамизола натрия.
Разработка и валидация методики количественного определения фенола методом газожидкостной хроматографии в биологических лекарственных препаратах
Authors: Колесникова Оксана Николаевна , Рунова Ольга Борисовна , Устинникова Ольга Борисовна
Published: June 2018

Разработана методика количественного определения фенола в биологических лекарственных препаратах методом газожидкостной хроматографии. Оптимальные условия хроматографирования были подобраны для колонки DB-WAX (размер 30 м  0,25 мм  0,25 мкм) фирмы Agilent Technologies; температура инжектора 250 °C; деление потока 40:1; объем пробы 0,5 мкл; газ-носитель гелий; режим — постоянное давление; скорость потока 1,4 мл/мин; температурный профиль печи: начальная температура 160 °C, выдержка 3 мин, градиент 40 °C/мин до температуры 200 °C выдержка 0,6 мин, градиент 40 °C до температуры 220 °C; время анализа 7,133 мин; температура детектора 250 °C. Методика валидирована, аналитическая область методики установлена в диапазоне концентраций от 1 до 5 мг/мл фенола; подтверждены правильность и специфичность методики, оценена прецизионность. Полученные результаты позволяют рассматривать данную методику в качестве альтернативной для количественного определения фенола в биологических лекарственных препаратах.
Estimación del índice de vegetación, en entornos urbanos forestados consolidados de baja densidad del área Metropolitana de Mendoza, Argentina
Authors: Arboit Mariela Edith
Published: June 2018

El objetivo del trabajo es estudiar la cobertura vegetal en entornos urbanos de baja densidad del Área Metropolitana de Mendoza (AMM), Argentina, a fin de comprender la morfología de ciudad forestada en clima árido. A nivel de verde urbano se ha determinado el índice de vegetación de diferencia normalizada (NDVI) a partir de datos satelitales para 32 manzanas urbanas representativas en el AMM y se cuantificó el mismo indicador en el AMM. El valor medio obtenido para los 32 entornos analizados es de 0.206, con el índice de vegetación más alto de 0.290 relacionado con el efecto positivo de la cubierta forestal y un valor mínimo de 0.148 en entornos con bajo porcentaje de arbolado urbano, alto porcentaje de transmisividad a la radiación solar y gran cantidad de superficie mineralizada expuesta directamente a dicha radiación. Se han podido conocer las condiciones actuales y la formulación de un diagnóstico de cobertura vegetal sobre la base del índice de vegetación.
La disputa de la ciudad: el rol de los actores sociales en la gobernanza del suelo urbano en la ciudad de Córdoba (Argentina)
Authors: Gargantini Daniela Mariana , Peresini Natalí
Published: June 2018

La ciudad se instituye como locus de los conflictos urbanos evidenciando las disputas de poder sobre su territorio. El acceso al suelo constituye uno de los procesos de mayor conflictividad en la consecución de un hábitat digno y de inclusión en la ciudad, por lo que considerar las representaciones y redes de interacción de los agentes involucrados favorece y potencia la comprensión de la producción física y simbólica de la ciudad. En el presente artículo se exponen, desde un enfoque cualitativo, los avances de la investigación en curso, referida al estudio del gobierno del suelo urbano en la ciudad de Córdoba (Argentina), a partir de la indagación y confrontación de las representaciones de actores sociales comunitarios influyentes, sus lógicas de comprensión y acción, así como las relaciones de articulación en torno a este conflicto urbano.
La educación moral en la universidad
Authors: Lopez Victoria Fernanda , Ariasgago Olga Leonor , Ojeda de Gómez María Cristina
Published: June 2018

La Universidad debe transmitir conocimientos científico - tecnológicos como también valores morales para formar profesionales competentes y responsables. La enseñanza de la ética busca proporcionar instrumentos para que los estudiantes desarrollen criterios sólidos, capacidad de dialogo y tomen decisiones prudentes y justas. En ciencias de la salud reviste radical importancia en la práctica profesional a fin de garantizar la atención sanitaria. El objetivo de este trabajo es presentar una revisión bibliográfica donde se analiza la formación moral, las perspectivas de la universidad, de los profesionales de la salud, del currículum universitario, del rol del profesor y de las propuestas pedagógicas. Se aborda la discusión de dilemas morales como estrategia para favorecer el desarrollo del juicio moral de los estudiantes a través de situaciones que presentan conflictos de valores. Se afirma que mediante la reflexión se crean las condiciones necesarias para el aprendizaje madurativo atravesando los distintos niveles de razonamiento moral.
GALLERY WALK’S AND PICTURE AND PICTURE TOWARD THE MATH’S RESULT STUDY
Authors: Mawardini Annisa , Prasetyo Teguh , Widyaningsih Hadida
Published: June 2018

This research based on the fact that how low Math’s result study is. That is why the researcher applied Gallery Walk and Picture and Picture method. The aim of this study is to figure out the influence of Gallery Walk’s method implementation and Picture and Picture toward the Math’s result study. The method used was quasi experiment with the static group pretest-postest design. The population in this research was all the student of fifth grader in Pasirgaok 02 elementary school. This research used nonprobability sampling as the technique of sampling which consisted of the saturated sample from two classes experiment. This research used observation, test and questionnaire as the technique of collecting data. According to the analysis result, the average score of posttest class of experiment 1 was 69,5 and the experiment two was 74,8. The result of One Sample T-test was sig 0.00, thus, it was rejected since 0.00 < 0.05 which means the method of Gallery Walk influenced toward the result study of the student. There was a difference in both method through independent T test, sig (2-tailed) 0,05 which rejected to emphasize the difference. So that, there was an influence of Gallery Walk’s method implementation and Picture and Picture toward the Math’s result studyof the fifth graders of Pasirgaok 02 elementary school.Keywords : Gallery Walk and Picture and Picture method, Math’s result study
Undocumented Students in Higher Education: A Review of the Literature, 2001 to 2016
Authors: Bjorklund Peter
Published: June 2018

This article presents a critical review of the recent literature on undocumented students in higher education, placing it in the context of recent anti-immigrant sentiment and policy revisions. The 81 reviewed studies reveal that undocumented students confront significant financial barriers, shoulder unique psychological and social burdens tied to their legal status, and lack access to forms of social capital that facilitate postsecondary success. At the same time, they bring a host of assets to college campuses—including civic engagement and resilience—that are underutilized. Although their experiences are dependent on ethnoracial group and geographic context, these differences have not been sufficiently studied. Likewise, researchers have not adequately explored the impact of institutional, state, and federal programs designed to help undocumented students. In sum, the recent literature sheds some light on the experiences of undocumented postsecondary students, but further research should yield a more nuanced picture and better address their needs.
Development and Implementation of VLSI Reconfigurable Architecture for Gabor Filter in Medical Imaging Application
Authors: Hegde Megha , Sivakumar P. Agalya
Published: June 2018

The Gabor filter is a very effective tool in visual
search approaches and multimedia applications. This filter
provides high resolution in time-frequency domains and thus
finds use in object recognition, character recognition and
pattern recognition applications. Medical Image analysis
using image processing algorithms is one of the best ways of
diagnosing diseases inside human body. The Gabor wavelets
resemble the visual cortex cell operation of mammalian
brains and hence are best suited for biological image analysis.
A Tonsillitis detection system is proposed here using Gabor
filtering approach. This system detects the presence of
Tonsillitis from the tonsils images. A suitable VLSI
architecture for the implementation of the Gabor filter was
modeled in Verilog using Xilinx tool and simulated using the
tonsils test images. The proposed system was successful in
detecting the presence of Tonsillitis from the diseased tonsils
image. The complete system was then synthesized and
implemented on FPGA Artix 7. The design was capable of
operating at a maximum frequency of 394.563 MHz.
Application and Usefulness of Internet of Things in Information Technology
Authors: Mohan Anand
Published: June 2018

The Internet of Things (IoT) is a system of
interrelated computing devices, mechanical and digital
machines, objects, animals or people that are provided with
unique identifiers and the ability to transfer data over a
network without requiring human-to-human or human-tocomputer
interaction. It is an ambiguous term, but it is fast
becoming a tangible technology that can be applied in data
centers to collect information on just about anything that
IT wants to control. IoT has evolved from the convergence
of wireless technologies, micro-electromechanical systems
(MEMS), microservices and the internet. The convergence
has helped tear down the silo walls between operational
technology (OT) and information technology (IT), allowing
unstructured machine-generated data to be analyzed for
insights that will drive improvements. The Internet of
Things (IoT) is essentially a system of machines or objects
outfitted with data-collecting technologies so that those
objects can communicate with one another. The machineto-machine
(M2M) data that is generated has a wide range
of uses, but is commonly seen as a way to determine the
health and status of things -- inanimate or living.
Infective Endocarditis in a Neonate
Authors: Dhungana Sangita Puree , Shrestha Sabina , Shrestha Sujit Kumar
Published: June 2018

Bacterial endocarditis in neonates is a rare. Generally neonates who develop endocarditis have required the invasive intensive care monitoring necessary for the support and treatment of a high-risk nursery population.  Neonatal Infective endocarditis is usually reported as a fatal disease. With early diagnosis and treatment we can change prognosis to better side.
Assessment of Nutritional Status of Children Attending Paediatrics OPD of a Tertiary Care Hospital in Eastern Nepal
Authors: Thakur Jitendra , Bhatta Nisha Keshary , Poudel Prakash , Shah Gouri Shankar , Singh Rupa Rajbandari
Published: June 2018

Introduction: Malnutrition is one of the major health problem worldwide, especially in developing world and so is in Nepal, the causes being numerous. The objectives of this study were to assess the nutritional status of children attending paediatric OPD of BPKIHS and to find relation of the nutritional status with different factors.Material and Methods: This descriptive cross sectional study was done by face to face interviews using semi-structured questionnaire and anthropometric variables were recorded. Data of total 192 children was analysed by descriptive statistics. p-value <0.05 was considered significant.Results: According to IAP classification 50.52% were malnourished [grade I 65.97%, grade II 26.8%, grade III 7.21%]. According to WHO classification 47.39% stuntedmoderate 89%, severe 11% and 9.89% wasted [moderate 94.73%, severe 5.26%]. Female sex, low education level in mother, low economic status, unavailability of exclusive breast feeding, low birth spacing and hospitalization were significantly associated with malnutrition.Conclusion: Malnutrition is common in children visiting paediatric OPD of BPKIHS. Female sex, maternal illiteracy, poverty, early weaning, birth spacing and hospitalization in past were major risk factors for malnutrition.
Observer Variability in Head Circumference Measurement Using Routine Versus Non-Stretchable Tapes in Children
Authors: Thakkar Pareshkumar Amrutlal , Yagnik Kinjal , Parmar Niyati T , Das Rashmi Ranjan , Thakkar Ukti P
Published: June 2018

Introduction: Observer variability is known in taking head circumference. Stretchable tapes do not provide accurate results after being used repeatedly. The aim of this study was to compare the intra-observer and inter-observer variability in measuring head circumference (HC) or occipito-frontal circumference (OFC) by using routine stretchable and non-stretchable tapes.Material and Methods: In this crosss-ectional study, all stable children in the age group of 1 month to 5 years attending the pediatric department of a tertiary care teaching hospital over six months period were included. The main outcome measures were: intra-observer & inter-observer variability in HC measurements by routinely used stretchable and non-stretchable tapes, and accuracy of readings of old stretchable tapes.Results: A total of 301 children were included. There was good correlation in the measurements taken by two observers (inter-observer), and three different readings of the same observer (intra-observer), correlation coefficient being > 0.99. With stretchable tape, 26% subjects had both intra-observer and inter-observer variability of ≥ 0.5 cm, which was 9.9% and 15.9% with the use of non-stretchable tape, respectively. Non-stretchable tape compared to stretchable tape had significantly less intra-observer (p < 0.001) and inter-observer variability (p=0.038).Conclusions: Observer variability was significantly less with the use of non-stretchable tapes compared to routinely used stretchable tapes. Old stretchable tapes used repeatedly over certain periods were not able to provide accurate readings.
Analisa SWOT Dalam Menentukan Strategi Bisnis Susu Murni Q-Milk
Authors: Miharja Kasmanto
Published: June 2018

Q-Milk adalah bisnis yang bergerak di bidang minuman segar dan sehat di daerah Cilodong Depok . Produk yang dihasilkan adalah susu murni Q-Milk dengan berbagai varian rasa tanpa bahan pengawet. Dalam menjalankan usaha perlu mengenali dan memahami diri perusahaan agar siap menghadapi dan memenangkan persaingan dengan para kompetitor. Penentuan strategi tersebut dapat dilakukan dengan analisis IFAS dan EFAS serta analisis SWOT untuk mengetahui apa yang menjadi kekuatan dan kelemahan perusahaan serta peluang dan ancaman yang harus dihadapi oleh perusahaan. Tujuan dari penelitian ini adalah untuk menganalisa faktor-faktor yang menjadi kekuatan, kelemahan, peluang dan ancaman bagi perusahaan serta menentukan strategi apa yang harus dilakukan untuk mengatasi pasang surutnya penjualan dengan menggunakan analisis IFAS, EFAS dan SWOT. Metode yang digunakan dalan penelitian ini adalah metode penelitian deskriptif. Data dalam penelitian ini diperoleh dari data primer dan hasil dari observasi, studi dokumentasi serta wawancara dengan informan penelitian yaitu manajer, karyawan dan konsumen. Hasil penelitiann menunjukkan bahwa posisi Q-Milk berada pada kuadran II, hal ini menunjukkan bahwa perusahaan menggunakan kekuatan dalam menghadapi berbagai ancaman. Berdasarkan analisis SWOT maka perusahaan dapat menggunakan strategi Diversifikasi dalam menjalankan usahanya. Dimana perusahaan dituntut untuk melakukan perubahan guna menutup kelemahan dan mengejar peluang yang ada, Hal yang harus dilakukan perusahaan yaitu : Pertahankan harga jual, lakukan inovasi dan terus ciptakan produk yang unik dan menarik, pertahankan kemasan produk sehingga menjadi ciri khas, tingkatkan kualitas produk, tingkatkan kegiatan promosi, memperluas wilayah distribusi agar produk Q-Milk lebih dikenal oleh masyarakat luas sehingga dapat memanfaatkan peluang yang ada.
Meningkatkan Kemampuan Motorik Halus melalui Teknik Mozaik pada Anak Kelompok B di TK Perdana Bangkinang Kota
Authors: Fauziddin Moh
Published: June 2018

Perkembangan kemampuan motorik halus anak usia dini kurang mendapatkan perhatian dari orang tua dan guru pada Lembaga PAUD. Hal ini banyak disebabkan kurangnya penguasaan orang tua dan guru terhadap cara yang tepat untuk mengembangkannya. Penelitian ini bertujuan untuk mengembangkan kemampuan motorik halus melalui teknik mozaik pada anak kelompok B TK Perdana bangkinang Kota, Kampar, Riau. Penelitian ini merupakan penelitian  tindakan kelas (classroom action research) yang dilakukan secara kolaboratif dan partisipatif. Subjek dalam penelitian adalah 22 anak, yang terdiri dari 16 anak perempuan dan  6 anak laki-laki. Metode pengumpulan data yang digunakan adalah observasi dan dokumentasi. Instrumen penelitian menggunakan lembar observasi. Teknik analisis data menggunakan deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa teknik  mozaik dapat  meningkatkan kemampuan motorik halus anak kelompok B TK Perdana Bangkinang Kota. Hal ini dibuktikan pencapaian kemampuan motorik halus, anak yang berkembang sangat baik  Langkah-langlah yang ditempuh dalam penelitian ini meliputi; menggunting, menempel, memegang pensil dan dan menyesuaikan warna.
Pengaruh Metode Story Telling melalui Pemanfaatan Program Power Point untuk Meningkatkan Kemampuan Mengenal Konsep Bilangan 1-10 Pada Anak Usia Dini Manyaran Semarang
Authors: Savitri Laila Nur
Published: June 2018

Penelitian ini bertujuan untuk mengetahui (1) efektifitas metode bercerita dengan program power point untuk anak usia dini, (2) mengetahuiÂ  perbedaanÂ  kelompok eksperimen dan kelompok kontrol. Pendekatan pada penelitian ini adalah kuantitatif Jenis penelitian adalah desain eksperimen dengan tehnik uji t (komparasi antara kelas eksperimen dengan kelas kontrol). Objek penelitian adalah 46 siswa kelompok A di TK PGRI 59 Manyaran. Uji coba instrumen dilakukan dengan uji reliabilitas antar rater dan analisis kuantitatif dilakukan dengan analisis uji t Independent Sample T Test. Hasil penelitian menunjukan bahwa: (1) PembelajaranÂ  Metode Bercerita dengan Penggunaan Program Power Point sangat efektif dengan hasil observasi kelas Eksperimen mendapatkan hasil rata-rata lebih tinggi (kelas Eksperimen 0,974, kelas Kontrol 0,767). Ini menunjukkan bahwa metode penggunaan program power point lebih diminati anak TK dibanding pembelajaran sehari-hari. (2) perbedaan antara kelompok eksperimen dan kelompok kontrol sudah terbukti, hasil dari (mean) rata-rata kelompok eksperimen 49, 9167 dan kelompok kontrol 32,9583. Hal ini dibuktikan dari hasil output SPSS sebesar 8,998 (0,05). Hasil dari P value 0,03, jadi Pvalue < 0,05. Pada derajat kebebasan 46 siswa (0,05) pada tabel kritis T (2,013). Dari hasil hitung 8,998 > 2,013. Ini menunjukan bahwa metode pembelajaran dengan penggunaan program power point di minati anak usia dini
Peningkatan Kemampuan Berbahasa Inggris Anak dengan Menggunakan Metode Total Physical Response Pada Kelompok B di TKIT Baitul Iman Semarang
Authors: Huda Nurul , Dahlia Sri Haryanti
Published: June 2018

Penelitian ini bertujuan meningkatkan kemampuan berbahasa Inggris anak pada kelompok B di TKIT Baitul Iman Semarang sekaligus sebagai syarat untuk menempuh S1 PAUD IKIP Veteran Semarang. Metode Total Physical Response (TPR) adalah teknik mengajar bahasa Inggris kepada anak dengan menggunakan respon fisik. Jenis penelitian ini menggunakan pendekatan penelitian tindakan kelas dengan obyek penelitian 20 anak kelompok B. Sumber data berasal dari hasil lembar observasi anak selama 2 siklus dan analisis data yang digunakanÂ  adalah analisis deskripsi kualitatif. Penelitian dilakukanÂ  sebanyak 2 siklus, dimana siklus I prosentase tercapainya indikator keberhasilan masih 5% saja. Setelah ditemukan kekurangan dan kelebihan pada siklus I, maka perbaikan dilakukan pada siklus II. Hasil observasi pada siklus II prosentase tercapainya indikator keberhasilan meningkat tajam menjadi 75%. Dengan demikian siklus dianggap selesai
PENGGUNAAN HP ANTARA MASYARAKAT DESA PESISIR DAN MASYARAKAT DESA PEGUNUNGAN
Authors: Eko Bambang Riawan
Published: June 2018

Handphone sebagai perangkat komunikasi banyak dimanfaatkan oleh setiap orang termasuk diantara masyarakat pesisir dan masyarakat pegunungan. Sebagai produk kebudaayaan, maka penggunaan HP sangat dipengaruhi oleh masyarakat dan sebalinya masyarakat akan memilih perangkat HP sesuai dengan kegunaannya sehingga menjadi puas. Penelitian ini menggunakan pendekatan diskriptip kuantitatif. Lokasi penelitian di Desa Jangkar Kecamatan Jangkar mewakili desa  pesisir dan Desa Telogo Sari, kecamatan Sumber Malang mewakili desa pegunungan. Penggalian data melalui  wawancara mendalam melalui kuesioner berstruktur kepada responden yang dipilih secara acak. Kesimpulan yang diperoleh adalah: (1) Jumlah orang yang menggunakan perangkat HP 2G saat ini masih banyak digunakan baik oleh masyarakat desa pesisir maupun desa pegunungan, sedang yang menggunakan android (4G) jumlahnya masih sedikit; (2).Telkomsel ternyata mendominasi provider baik di desa pesisir maupun di desa pegunungan. Meskipun begitu desa pesisir lebih variatif  jumlah providernya lebih banyak dibanding dengan desa pegunungan; (3). Umur adalah salah satu faktor yang mempengaruhi seseorang dalam menggunakan perangkat HP