bluuebunny/crossref_metadata_2025 huggingface dataset:
Early use of airway pressure release ventilation in acute respiratory distress syndrome induced by coronavirus disease 2019: a case report
Authors: Sinatra Jadeny , Salim Ronnie Wirawan , Tanoto Epifanus Arie , Hariyanto Hori
Published: December 2022

Background

Coronavirus disease 2019 is a highly transmissible and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2, a novel coronavirus that was identified in early January 2020 in Wuhan, China, and has become a pandemic disease worldwide. The symptoms of coronavirus disease 2019 range from asymptomatic to severe respiratory failure. In moderate and severe cases, oxygen therapy is needed. In severe cases, high-flow nasal cannula, noninvasive ventilation, and invasive mechanical ventilation are needed. Many ventilation methods in mechanical ventilation can be used, but not all are suitable for coronavirus disease 2019 patients. Airway pressure release ventilation, which is one of the mechanical ventilation methods, can be considered for patients with moderate-to-severe acute respiratory distress syndrome. It was found that oxygenation in the airway pressure release ventilation method was better than in the conventional method. How about airway pressure release ventilation in coronavirus disease 2019 patients? We report a case of confirmed coronavirus disease 2019 in which airway pressure release ventilation mode was used.

Case presentation

In this case study, we report a 74-year-old Chinese with a history of hypertension and uncontrolled diabetes mellitus type 2. He came to our hospital with the chief complaint of difficulty in breathing. He was fully awake with an oxygen saturation of 82% on room air. The patient was admitted and diagnosed with severe coronavirus disease 2019, and he was given a nonrebreathing mask at 15 L per minute, and oxygen saturation went back to 95%. After a few hours with a nonrebreathing mask, his condition worsened. On the third day after admission, saturation went down despite using noninvasive ventilation. We decided to intubate the patient and used airway pressure release ventilation mode. Finally, after 14 days of being intubated, the patient could be extubated and discharged after 45 days of hospitalization.

Conclusion

Early use of airway pressure release ventilation may be considered as one of the ventilation strategies to treat severe coronavirus disease 2019 acute respiratory distress syndrome. Although reports on airway pressure release ventilation and protocols on its initiation and titration methods are limited, it may be worthwhile to consider, given its known ability to maximize alveolar recruitment, preserve alveolar epithelial integrity, and surfactant, all of which are crucial for handling the “fragile” lungs of coronavirus disease 2019 patients.
Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes
Authors: Chirico Nino , Kessler Elise L. , Maas Renée G. C. , Fang Juntao , Qin Jiabin , Dokter Inge , Daniels Mark , Šarić Tomo , Neef Klaus , Buikema Jan-Willem , Lei Zhiyong , Doevendans Pieter A. , Sluijter Joost P. G. , van Mil Alain
Published: December 2022

Background

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPSC-CMs) do not display all hallmarks of mature primary cardiomyocytes, especially the ability to use fatty acids (FA) as an energy source, containing high mitochondrial mass, presenting binucleation and increased DNA content per nuclei (polyploidism), and synchronized electrical conduction. This immaturity represents a bottleneck to their application in (1) disease modelling—as most cardiac (genetic) diseases have a middle-age onset—and (2) clinically relevant models, where integration and functional coupling are key. So far, several methods have been reported to enhance iPSC-CM maturation; however, these protocols are laborious, costly, and not easily scalable. Therefore, we developed a simple, low-cost, and rapid protocol to promote cardiomyocyte maturation using two small molecule activators of the peroxisome proliferator-activated receptor β/δ and gamma coactivator 1-alpha (PPAR/PGC-1α) pathway: asiatic acid (AA) and GW501516 (GW).

Methods and Results

Monolayers of iPSC-CMs were incubated with AA or GW every other day for ten days resulting in increased expression of FA metabolism-related genes and markers for mitochondrial activity. AA-treated iPSC-CMs responsiveness to the mitochondrial respiratory chain inhibitors increased and exhibited higher flexibility in substrate utilization. Additionally, structural maturity improved after treatment as demonstrated by an increase in mRNA expression of sarcomeric-related genes and higher nuclear polyploidy in AA-treated samples. Furthermore, treatment led to increased ion channel gene expression and protein levels.

Conclusions

Collectively, we developed a fast, easy, and economical method to induce iPSC-CMs maturation via PPAR/PGC-1α activation. Treatment with AA or GW led to increased metabolic, structural, functional, and electrophysiological maturation, evaluated using a multiparametric quality assessment.
Efficient bone regeneration of BMP9-stimulated human periodontal ligament stem cells (hPDLSCs) in decellularized bone matrix (DBM) constructs to model maxillofacial intrabony defect repair
Authors: Zhang Yuxin , Luo Wenping , Zheng Liwen , Hu Jing , Nie Li , Zeng Huan , Tan Xi , Jiang Yucan , Li Yeming , Zhao Tianyu , Yang Zhuohui , He Tong-Chuan , Zhang Hongmei
Published: December 2022

Background

BMP9-stimulated DPSCs, SCAPs and PDLSCs are effective candidates for repairing maxillofacial bone defects in tissue engineering, while the most suitable seed cell source among these three hDMSCs and the optimal combination of most suitable type of hDMSCs and BMP9 have rarely been explored. Moreover, the orthotopic maxillofacial bone defect model should be valuable but laborious and time-consuming to evaluate various candidates for bone regeneration. Thus, inspired from the maxillofacial bone defects and the traditional in vivo ectopic systems, we developed an intrabony defect repair model to recapitulate the healing events of orthotopic maxillofacial bone defect repair and further explore the optimized combinations of most suitable hDMSCs and BMP9 for bone defect repair based on this modified ectopic system.

Methods

Intrabony defect repair model was developed by using decellularized bone matrix (DBM) constructs prepared from the cancellous part of porcine lumbar vertebral body. We implanted DBM constructs subcutaneously on the flank of each male NU/NU athymic nude mouse, followed by directly injecting the cell suspension of different combinations of hDMSCs and BMP9 into the central hollow area of the constructs 7 days later. Then, the quality of the bony mass, including bone volume fraction (BV/TV), radiographic density (in Hounsfield units (HU)) and the height of newly formed bone, was measured by micro-CT. Furthermore, the H&E staining and immunohistochemical staining were performed to exam new bone and new blood vessel formation in DBM constructs.

Results

BMP9-stimulated periodontal ligament stem cells (PDLSCs) exhibited the most effective bone regeneration among the three types of hDMSCs in DBM constructs. Furthermore, an optimal dose of PDLSCs with a specific extent of BMP9 stimulation was confirmed for efficacious new bone and new blood vessel formation in DBM constructs.

Conclusions

The reported intrabony defect repair model can be used to identify optimized combinations of suitable seed cells and biological factors for bone defect repair and subsequent development of efficacious bone tissue engineering therapies.
Ostrowski-type inequalities pertaining to Atangana–Baleanu fractional operators and applications containing special functions
Authors: Sahoo Soubhagya Kumar , Kodamasingh Bibhakar , Kashuri Artion , Aydi Hassen , Ameer Eskandar
Published: December 2022

The objective of this article is to incorporate the concept of the Ostrowski inequality with the Atangana–Baleanu fractional integral operator. A novel integral identity for twice-differentiable functions is established after a rigorous investigation of several basic definitions and existing ideas related to inequalities and fractional calculus. Following that, numerous Ostrowski-type inequalities are provided based on this identity, which uses Mittag–Leffler as its kernel structure. Some specific applications, such as q-digamma functions and modified Bessel functions, are also investigated. Choosing $s=1$
s
=
1
, we also analyze new results for convex functions as special cases. Our findings corroborate some well-documented inequalities.
Steady states of a diffusive predator-prey model with prey-taxis and fear effect
Authors: Cao Jianzhi , Li Fang , Hao Pengmiao
Published: December 2022

In this paper, a diffusive predator-prey system with a prey-taxis response subject to Neumann boundary conditions is considered. The stability, the Hopf bifurcation, the existence of nonconstant steady states, and the stability of the bifurcation solutions of the system are analyzed. It is proved that a high level of prey-taxis can stabilize the system, the stability of the positive equilibrium is changed when χ crosses $\chi _{0}$

χ
0

, and the Hopf bifurcation occurs for the small s. The system admits nonconstant positive solutions around $(\bar{u}, \bar{v}, \chi _{i} )$
(

u
¯

,

v
¯

,

χ
i

)
, the stability of bifurcating solutions are controlled by $\int _{\Omega} \Phi _{i}^{3} \,\mathrm{d}x$

∫
Ω

Φ
i
3

d
x
and $\int _{\Omega} \Phi _{i}^{4} \,\mathrm{d}x$

∫
Ω

Φ
i
4

d
x
. Finally, numerical simulation results are carried out to verify the theoretical findings.
Violence Detection Approach based on Cloud Data and Neutrosophic Cognitive Maps
Authors: Wajid Mohammad Saif , Terashima-Marin Hugo , Paul Rad Peyman Najafirad , Wajid Mohd Anas
Published: December 2022

Violence has remained a momentous problem since time immemorial. Various scientific studies are conducted in the recent past to identify the stimuli causing violent behavior among the masses and to achieve the target of cloud data protection. Given the inherent ambiguity or indeterminacy in human behaviour, this study in the area of violence detection appears to be effective, as it finds a variety of stimuli and character qualities that contribute to violent conduct among masses. This uncertainty of traits causing violence can easily be seen in surveillance data present over the cloud and also from the data collected using academic research. Therefore, for the purpose of identifying violent behavior we have considered the factors (data) from existing research and from data over clouds. The factors that lead to violent behavior and are identified by algorithms running over clouds are termed as determinate or certain factors. The factors that were not considered and least identified by the cloud algorithms and given less importance are termed indeterminate factors or uncertain factors. The indeterminate factors are also considered based on the expert’s opinion where the experts are not in a condition to provide a clear stance or when they are neutral in their opinion. Tests are performed using Neutrosophic Cognitive Maps (NCMs) to model the violent behavior taking into consideration both determinate and indeterminate factors. Earlier these tests were performed using Fuzzy Cognitive Maps (FCMs) where indeterminate or uncertain factors were not considered. Therefore, we provide a brief comparison between NCMs and FCMs and show how effective NCMs are when we need to consider the uncertainty of concepts while carrying out tests for identifying violent behavior. Later results are obtained by forming a Neutrosophic adjacency matrix which is evaluated using the concepts of linear algebra. The obtained results in the form of 1 ∗ nvector (1 I I I I 1 I 1 I I I I I I I I I I I ) clearly shows the presence of indeterminate factor‘I’in the vector which was absent in earlier models when designed using FCMs. This shows how these indeterminate or uncertain factors play a significant role in cultivating violent behavior which was not shown in the previous study. The study is significant since it takes into account factors from cloud data, experts’ opinions, and also from literature, and shows how these factors are taken into consideration at the data level itself so that they will not impact the modeling stage, and machine learning algorithms will perform well because uncertain and indeterminate information is taken care of at training phase itself. Hence uncertainty could be reduced in machine learning algorithms and in the overall recognition of violent behavior.
Use of the Superblock model for promoting physical activity in Barcelona: a one-year observational comparative study
Authors: Puig-Ribera Anna , Arumí-Prat Ignasi , Cirera Eva , Solà Marta , Codina-Nadal Anna , Palència Laia , Biaani Brenda , Pérez Katherine
Published: December 2022

Background

The Barcelona Superblock model transforms urban public spaces into active-friendly spaces, a key issue for public health. This study assessed the extent to which a newly developed Superblock in St. Antoni Market Square was used by citizens to perform physical activities and for sedentary behaviour during the first year of implementation. It then compared this citizens’ use of the Superblock for physical activities and sedentary behaviour with a comparison site at one-year follow-up, when the Superblock was fully integrated into citizens’ daily life.

Methods

This observational comparative study (May 2018-May 2019) used the System for Observing Play and Recreation in Communities (SOPARC). SOPARC assessed citizens’ sitting, standing, walking, practice of vigorous activities and use of electric scooter by gender, age group and time of the day. At the Superblock site, two observers completed five weekly observations: the opening week, and at three, five, eight and twelve months. At the comparison site, observers completed one weekly observation at twelve months after the implementation of the Superblock. Observations included 4 days/week (including weekends) and, 4 h/day (morning, midday, afternoon, evening).

Results

At baseline, an average of 2,340 citizens/hour were observed using the Superblock but visits reduced by 12% in the next three observation weeks and 17.6% after one-year (mainly elderly and teenagers). At baseline, 92.9% walked in the Superblock, while 3.1% engaged in vigorous physical activity. After one year, citizens’ walking decreased by 18.2%, from 2,170 citizens/hour at baseline to 1,930 citizens/hour. Citizens’ engagement in vigorous activities also declined by 11%, from 73 citizens/hour at baseline to 65 citizens/hour at one-year follow up. In the comparison site, citizens’ usage for walking and vigorous physical activity was similar to the Superblock.

Conclusions

This is the first study to assess the extent to which citizens made use of the Barcelona Superblock model to perform physical activities, an urban built-environment intervention that is both novel and health-enhancing. The Superblock model would benefit from strategies maximizing effectiveness for promoting superblock-based physical activity, with special focus on seniors and teenagers.
Transgender and other gender diverse adolescents with eating disorders requiring medical stabilization
Authors: Chaphekar Anita V. , Vance Stanley R. , Garber Andrea K. , Buckelew Sara , Ganson Kyle T. , Downey Amanda , Nagata Jason M.
Published: December 2022

Background

Despite the high prevalence of eating disorders in gender diverse adolescents, little is known about the characteristics of gender diverse youth with eating disorders who require inpatient medical stabilization. The primary objective of this study was to describe the medical, anthropometric, and psychiatric characteristics of gender diverse adolescents hospitalized for eating disorders and compare these characteristics to cisgender peers hospitalized for eating disorders. The secondary objective was to evaluate percent median body mass index as one marker of malnutrition and treatment goal body mass index as a recovery metric between patients’ birth-assigned sex and affirmed gender using standardized clinical growth charts.

Methods

A retrospective chart review was conducted of 463 patients admitted to an inpatient eating disorders medical unit between 2012 and 2020. To compare medical, anthropometric, and psychiatric data between gender diverse and cisgender patients, chi-square/Fisher’s exact and t-tests were used. Clinical growth charts matching the patients’ birth-assigned sex and affirmed gender identity were used to assess percent of median body mass index and treatment goal body mass index.

Results

Ten patients (2.2%) identified as gender diverse and were younger than cisgender patients [13.6 (1.5) years vs. 15.6 (2.7) years, p = 0.017]. Gender diverse patients were hospitalized with a higher percent median body mass index compared to cisgender peers [97.1% (14.8) vs. 87.9% (13.7), p = 0.037], yet demonstrated equally severe vital sign instability such as bradycardia [44 (8.8) beats per minute vs. 46 (10.6) beats per minute, p = 0.501], systolic hypotension [84 (7.1) mmHg vs. 84 (9.7) mmHg, p = 0.995], and diastolic hypotension [46 (5.8) mmHg vs. 45 (7.3) mmHg, p = 0.884]. Gender diverse patients had a higher prevalence of reported anxiety symptoms compared to cisgender patients (60% vs. 28%, p = 0.037).

Conclusions

Gender diverse patients demonstrated complications of malnutrition including vital sign instability despite presenting with a higher weight. This is consistent with a greater proportion of gender diverse patients diagnosed with atypical anorexia nervosa compared to cisgender peers. Additionally, psychiatric comorbidities were present among both groups, with a larger percentage of gender diverse patients endorsing anxiety compared to cisgender patients.
Evaluation of selected short-term predictions of UT1-UTC and LOD collected in the second earth orientation parameters prediction comparison campaign
Authors: Kur Tomasz , Dobslaw Henryk , Śliwińska Justyna , Nastula Jolanta , Wińska Małgorzata , Partyka Aleksander
Published: December 2022

Advanced geodetic and astronomical tasks, such as precise positioning and navigation require forecasted Earth Orientation Parameters (EOP). The Second Earth Orientation Parameters Prediction Comparison Campaign (2nd EOP PCC) aims to compare various EOP forecast methods implemented by different institutes from all over the world. Here we focus on universal time (UT1-UTC) and Length-of-Day (LOD) predictions received in the period between September 1st, 2021 and May 29th, 2022. The forecasts are preliminarily evaluated against the EOP 14 C04 solution delivered by the International Earth Rotation and Reference System Service (IERS) by using the mean absolute error (MAE) as the prediction quality measure. Exemplarily, we compare forecasts from IERS delivered by U.S. Naval Observatory (USNO) and a selected campaign participant to assess the impact of both input data and computation methodology on predictions. We show that improper treatment of long-periodic ocean tides has severely degraded LOD forecasting until this issue has been brought to the attention of the participant during a meeting of the 2nd EOP PCC. We consider this as a good example for the benefit of the campaign to the overall scientific community by providing specific feedback to individual processing centres on deficits in their products, which lead to quick and effective adaptations. The lessons learned from this analysis could be applied to other EOP forecasting methods based on Effective Angular Momentum (EAM) predictions.

Graphical Abstract
Detection of prostate cancer using diffusion-relaxation correlation spectrum imaging with support vector machine model – a feasibility study
Authors: Wei Xiaobin , Zhu Li , Zeng Yanyan , Xue Ke , Dai Yongming , Xu Jianrong , Liu Guiqin , Liu Fang , Xue Wei , Wu Dongmei , Wu Guangyu
Published: December 2022

Background

To evaluate the performance of diffusion-relaxation correlation spectrum imaging (DR-CSI) with support vector machine (SVM) in detecting prostate cancer (PCa).

Methods

In total, 114 patients (mean age, 66 years, range, 48–87 years) who received a prostate MRI and underwent biopsy were enrolled in three stages. Thirty-nine were assigned for the exploration stage to establish the model, 18 for the validation stage to choose the appropriate scale for mapping and 57 for the test stage to compare the diagnostic performance of the DR-CSI and PI-RADS.

Results

In the exploration stage, the DR-CSI model was established and performed better than the ADC and T2 values (both P < 0.001). The validation result shows that at least 2 pixels were required for both the long-axis and short-axis in the mapping procedure. In the test stage, DR-CSI had higher accuracy than PI-RADS ≥ 3 as a positive finding based on patient (84.2% vs. 63.2%, P = 0.004) and lesion (78.8% vs. 57.6%, P = 0.001) as well as PI-RADS ≥ 4 on lesion (76.5% vs. 64.7%, P = 0.029), while there was no significant difference between DR-CSI and PI-RADS ≥ 4 based on patient (P = 0.508). For clinically significant PCa, DR-CSI had higher accuracy than PI-RADS ≥ 3 based on patients (84.2% vs. 63.2%, P = 0.004) and lesions (62.4% vs. 48.2%, P = 0.036). There was no significant difference between DR-CSI and PI-RADS ≥ 4 (P = 1.000 and 0.845 for the patient and lesion levels, respectively).

Conclusions

DR-CSI combined with the SVM model may improve the diagnostic accuracy of PCa.

Trial registration

This study was approved by the Ethics Committee of our institute (Approval No. KY2018-213). Written informed consent was obtained from all participants.
Approaches to co-production of research in care homes: a scoping review
Authors: Hallam-Bowles F. V. , Logan P. A. , Timmons S. , Robinson K. R.
Published: December 2022

Background

Using the technique of co-production to develop research is considered good practice. Co-production involves the public, practitioners and academics working together as equals throughout a research project. Co-production may help develop alternative ways of delivering care for older adults that are acceptable to those who live and work in care homes. However, guidance about applying co-production approaches in this context is lacking. This scoping review aims to map co-production approaches used in care homes for older adults in previous research to support the inclusion of residents and care staff as equal collaborators in future studies.

Methods

A scoping review was conducted using the Joanna Briggs Institute scoping review methodology. Seven electronic databases were searched for peer-reviewed primary studies using co-production approaches in care home settings for older adults. Studies were independently screened against eligibility criteria by two reviewers. Citation searching was completed. Data relating to study characteristics, co-production approaches used, including any barriers and facilitators, was charted by one reviewer and checked by another. Data was summarised using tables and diagrams with an accompanying narrative description. A collaborator group of care home and health service representatives were involved in the interpretation of the findings from their perspectives.

Results

19 studies were selected for inclusion. A diverse range of approaches to co-production and engaging key stakeholders in care home settings were identified. 11 studies reported barriers and 13 reported facilitators affecting the co-production process. Barriers and facilitators to building relationships and achieving inclusive, equitable and reciprocal co-production were identified in alignment with the five NIHR principles. Practical considerations were also identified as potential barriers and facilitators.

Conclusion

The components of co-production approaches, barriers and facilitators identified should inform the design of future research using co-production approaches in care homes. Future studies should be explicit in reporting what is meant by co-production, the methods used to support co-production, and steps taken to enact the principles of co-production. Sharing of key learning is required to support this field to develop. Evaluation of co-production approaches, including participants’ experiences of taking part in co-production processes, are areas for future research in care home settings.
Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors
Authors: Wang Chen , Wang Di , Pan Changqing , Zhang Jiazheng , Cheng Cheng , Zhai You , Yu Mingchen , Wang Zhiliang , Li Guanzhang , Zhang Wei
Published: December 2022

Background

Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed with primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics and prognosis of these patients. The data presented here compared the clinical and pathological features between glioblastoma patients with or without primary non-CNS tumors, trying to further explore this complex situation.

Methods

Statistical analysis was based on the clinical and pathological data of 45 patients who were diagnosed with isocitrate dehydrogenase (IDH) wild-type glioblastoma accompanied by non-CNS tumors between January 2019 and February 2022 in Beijing Tiantan Hospital. Univariate COX proportional hazard regression model was used to determine risk factors for overall survival.

Results

It turned out to be no significant difference in the overall survival (OS) of the 45 patients with IDH-wild-type GBM plus non-CNS tumors, compared with the 112 patients who were only diagnosed with IDH-wild-type GBM. However, there was a significant difference in OS of GBM patients with benign tumors compared to those with malignant tumors.

Conclusions

Implications for the non-central nervous system tumors on survival of glioblastomas were not found in this research. However, glioblastomas complicated with other malignant tumors still showed worse clinical outcomes.
Stages of preadipocyte differentiation: biomarkers and pathways for extracellular structural remodeling
Authors: Hu Zhihan , Liu Yi , Yao Zongjiang , Chen Liming , Wang Gang , Liu Xiaohui , Tian Yafei , Cao Guangtong
Published: December 2022

Background

This study utilized bioinformatics to analyze the underlying biological mechanisms involved in adipogenic differentiation, synthesis of the extracellular matrix (ECM), and angiogenesis during preadipocyte differentiation in human Simpson–Golabi–Behmel syndrome at different time points and identify targets that can potentially improve fat graft survival.

Results

We analyzed two expression profiles from the Gene Expression Omnibus and identified differentially expressed genes (DEGs) at six different time points after the initiation of preadipocyte differentiation. Related pathways were identified using Gene Ontology/Kyoto Encyclopedia of Genes and Genomes analyses and Gene Set Enrichment Analysis (GSEA). We further constructed a protein–protein interaction (PPI) network and its central genes. The results showed that upregulated DEGs were involved in cell differentiation, lipid metabolism, and other cellular activities, while downregulated DEGs were associated with angiogenesis and development, ECM tissue synthesis, and intercellular and intertissue adhesion. GSEA provided a more comprehensive basis, including participation in and positive regulation of key pathways of cell metabolic differentiation, such as the “peroxisome proliferator-activated receptor signaling pathway” and the “adenylate-activated protein kinase signaling pathway,” a key pathway that negatively regulates pro-angiogenic development, ECM synthesis, and adhesion.

Conclusions

We identified the top 20 hub genes in the PPI network, including genes involved in cell differentiation, ECM synthesis, and angiogenesis development, providing potential targets to improve the long-term survival rate of fat grafts. Additionally, we identified drugs that may interact with these targets to potentially improve fat graft survival.
Cognitive and psychological factors associated with severe insomnia in Brazilian women: a cross-sectional study
Authors: El Rafihi-Ferreira Renatha , do Brasil do Carmo Marwin Machay Indio , Bassolli Lucas , Hasan Rosa , Aizawa Isabela Mayumi Nishino , Toscanini Andrea Cecilia
Published: December 2022

Insomnia is the most prevalent sleep disorder in women. Sociodemographic, cognitive, and psychological factors may contribute to its severity. This study evaluated factors associated with severe insomnia in women with insomnia complaints. We evaluated 530 women aged 18–59 (mean = 40.5,SD= 10.2), who experienced insomnia complaints, using self-report instruments. Severe insomnia was defined as a score above 21 on the Insomnia Severity Index. Age, marital status, educational level, depression and anxiety, psychological inflexibility, and beliefs about sleep were assessed as potential factors associated with severe insomnia. Simple and multivariate analyses were conducted using binary logistic regression. Low education level (odds ratio;OR= 1.85 [1.27–2.69]), depression (OR= 2.17 [1.27–3.81]), psychological inflexibility (OR= 1.05 [1.02–1.08]), and dysfunctional beliefs about sleep (OR= 1.04 [1.02–1.06]) were factors associated with severe insomnia scores in the multiple logistic regression model. These findings are important from a public health perspective, because behavioral strategies designed to treat insomnia with a focus on cognitive and psychological factors are low-cost treatments and may help improve sleep quality in women, which also influences mental health.
Clinical characteristics and laboratory parameters in differentiating dengue from other acute febrile illnesses
Authors: Juliansen Andry , Budiputri Charista Lydia , Meliani Fellisa , Muljono Michelle Patricia , Heriyanto Rivaldo Steven , Chandra Shally , Octavius Gilbert Sterling
Published: December 2022

Background

Dengue infection is one of the most common viral infections globally, with a broad spectrum of clinical manifestations, including hemorrhage and shock. Early diagnostic confirmation of dengue infection is essential, but some areas may not have the appropriate diagnostic tools while its clinical symptoms are similar to other diseases. We aim to determine some significant clinical characteristics and laboratory parameters in differentiating dengue from other causes of febrile.

Results

This study included 527 dengue patients and 268 control patients. Multivariate analysis showed older age (OR = 12.11; 95% 5.42–26.63, p < 0.001), the absence of diarrhea (OR = 0.12; 95% CI 0.06–0.25, p < 0.001), leukopenia (OR = 13.35; 95% CI 4.99–38.71, p < 0.001), thrombocytopenia (OR = 7.12; 95% CI 2.37–21.38, p < 0.001), and normal ESR (OR = 3.03; 95% CI 1.54–5.96, p = 0.001) are significant parameters in differentiating dengue with excellence (AUC value of 0.96) and good fit of the model (p value = 0.8). The cut-off is two significant variables with a sensitivity of 91.4% and specificity of 87.5%.

Conclusions

Two or more clinical signs can help clinicians differentiate dengue from other acute febrile illnesses.
Added value of a chest multidetector computed tomography scoring system in the assessment of chronic lung disease among pediatric patients
Authors: Hafez Mona Ahmed Fouad , Singh Chandan Kumar , Sayed Yasmin Saied Aly , Mahmoud Reham Osama
Published: December 2022

Background

Pediatric chronic lung disease (CLD) represents a heterogeneous group of several distinct clinical entities, with its prevalence increasing over the last decade. The current study aimed to identify the role of chest multidetector computed tomography (MDCT) using modified Bhalla scoring for the early diagnosis of CLD in pediatric patients and determine the most common chest MDCT findings. This prospective study involved 45 pediatric patients with chronic respiratory symptoms, all of whom underwent MDCT. Thereafter, data were analyzed using the modified Bhalla score.

Results

Chronic lung diseases were classified according to their radiological and clinical criteria. The total CT score, which was the most significant factor for chronic inhalation and chronic recurrent inflammatory lung diseases, varied between 2 and 21 points, with those having autoimmune diseases exhibiting the largest value for the mean CT score. The clinical severity of symptoms was not correlated with CT score.

Conclusion

Our findings showed that MDCT was a useful tool for diagnosing pediatric CLD and assessing disease extent, severity, and superimposed complications. The modified Bhalla CT scoring system allowed for systematic primary and follow-up assessments of various lung lesions in cases with varying CLD etiologies.
Mechanical properties of concrete at low and ultra-low temperatures- a review
Authors: Huo Yanlin , Sun Huayang , Lu Dong , Chen Zhitao , Yang Yingzi
Published: December 2022

As infrastructure construction advances toward the cold and highland environment, concrete preparation technology and service performance in the cold climate is receiving much attention. The freezing of pore water inside concrete leads to significant changes in its mechanical properties at negative temperatures. Therefore, to ensure the safety of civil engineering structures in cold regions, it is necessary to fully understand the change law and enhancement mechanism of the mechanical properties of concrete and be able to predict mechanical properties at a negative temperature. Since the 1970s, scholars have studied concrete’s negative temperature mechanical properties in different water-content states. This paper presents a comprehensive review of the changes in mechanical properties of concrete at low and ultra-low temperatures and further elucidates the evolution of its compressive strength, tensile strength, flexural strength, elastic modulus, and stress-strain relationship at low temperatures. It was found that the main factors affecting the mechanical properties of concrete at low temperatures were temperature and moisture content. The strength of concrete increases significantly with the decrease in temperature and the increase in moisture content. To better understand and predict the mechanical properties of concrete at low temperatures, the best model was suggested by analyzing the prediction models of different researchers and considering the dispersion of the data. Further, based on the G. Wiedemann pore model, the changes in the internal structure of concrete at low temperatures are described in detail, and the mechanism of its mechanical property enhancement is analyzed.
An information entropy-based risk assessment method for multiple-media gathering pipelines
Authors: Qin Guojin , Tang Shengyu , Li Ruiling , Xia Ailin , Zhang Zhenwei , Wang Yihuan
Published: December 2022

Unrefined and highly corrosive upstream petroleum resources and complex operating environments pose a significant threat to the integrity and safety of gathering pipelines. The present study proposed a novelty method to perform a risk assessment for gathering pipelines. The use of historical failure data developed a fishbone diagram model of hazard factors. The risk index system was developed based on the KENT method, including failure likelihood and failure consequence coefficient models. Information entropy theory was used to determine the weight of each indicator. Combined with the area-level safety design coefficient, The welding institute (TWI) method was improved to perform risk classification for different areas. The proposed method was applied to 81 gathering pipelines. Results demonstrated that the proposed method could meet the actual conditions of gathering pipelines, improving upstream energy security.
A framework for improving bridge resilience and sustainability through optimizing high-performance fiber-reinforced cementitious composites
Authors: Tan Xiao , Mahjoubi Soroush , Zhang Qinghua , Dong Daren , Bao Yi
Published: December 2022

High-performance fiber-reinforced cementitious composites (HPFRCC) exhibit benefits in improving infrastructure resilience but often compromise sustainability due to the higher upfront cost and carbon footprint compared with conventional concrete. This paper presents a framework to improve bridge resilience and sustainability through optimizing HPFRCC. This research considers ultra-high-performance concrete and strain-hardening cementitious composite, both featuring high mechanical strengths, ductility, and damage tolerance. This paper establishes links between bridge resilience, bridge sustainability, mechanical properties of HPFRCC, and mixture design. The investigated mechanical properties include the first crack stress, the ultimate tensile strength, and the ultimate tensile strain. With the established links, sustainability is maximized while resilience is retained by optimizing HPFRCC mixtures. The framework is implemented into a case study of a bridge that collapsed during construction. Results show that use of HPFRCC enhances resilience, and HPFRCC mixtures can be engineered to minimize the material cost and carbon footprint while retaining high resilience.
A review on hepatitis C virus: role of viral and host-cellular factors in replication and existing therapeutic strategies
Authors: Butt Fatima , Shahid Muhammad , Hassan Muhammad , Tawakkal Farah , Amin Iram , Afzal Samia , Bhatti Rashid , Nawaz Rabia , Idrees Muhammad
Published: December 2022

Background

Hepatitis C virus, a member of Flaviviridae is a single-stranded positive-sense RNA virus infecting 62–79 million people around the globe. This blood-borne virus is one of the leading causes of liver diseases worldwide. This review aims to identify novel potential genes linked to cellular host factors, as well as revise the roles of each gene in hepatitis C Virus infection. This review also aims to provide a comprehensive insight into therapeutic advancements against HCV.

Methods

For this review article, 190 articles were searched via PubMed Central, Bio-One, National Academy of Science, Google Scholar, and Worldwide Science. 0ut of these 190 studies, 55 articles were selected for this review. The inclusion of articles was done on the criteria of high citation and Q1 ranking.

Results

The information gathered from previously published articles highlighted a critical link between host-cellular factors that are important for HCV infection.

Conclusion

Although many advancements in HCV treatment have been made like DAAs and HTAs, the development of a completely effective HCV therapy is still a challenge. Further research on combinations of DAAs and HTAs can help in developing a better therapeutic alternative. Keywords: Hepatitis C virus, Replication cycle, Non-structural proteins, Host-cellular factors, Treatment strategies
Co-teaching in Undergraduate STEM Education: A Lever for Pedagogical Change toward Evidence-Based Teaching?
Authors: Haag Kirstin , Pickett Sarah B. , Trujillo Gloriana , Andrews Tessa C.
Published: December 2022

Co-teaching has been proposed as a lever for fostering pedagogical change and has key attributes of a successful change strategy, but does research indicate co-teaching effectively shifts instructional practices? This essay, written with a few audiences in mind, reviews existing evidence, extracts recommendations, and lays out future directions.
Climate change and mental health in the Philippines
Authors: Alibudbud Rowalt Carpo
Published: December 2022

The mental health repercussions of the climate crisis are observed annually in the Philippines, one of the world's most climate-vulnerable countries. This paper explores these repercussions by examining the aftermath of Typhoon Haiyan. It shows that mental health problems persisted beyond the typhoon's immediate aftermath among a large number of survivors. Since the mental health system was fragile, the affected community improved their mental health services through the help of local and international non-governmental organisations. Nonetheless, several challenges must be addressed as the country faces the climate crisis.
Continuous Subcutaneous Insulin Infusions: Closing the Loop
Authors: Díaz-Balzac Carlos A , Pillinger David , Wittlin Steven D
Published: December 2022

Context

Continuous subcutaneous insulin infusions (CSIIs) and continuous glucose monitors (CGMs) have revolutionized the management of diabetes mellitus (DM). Over the last 2 decades the development of advanced, small, and user-friendly technology has progressed substantially, essentially closing the loop in the fasting and postabsorptive state, nearing the promise of an artificial pancreas (AP). The momentum was mostly driven by the diabetes community itself, to improve its health and quality of life.

Evidence Acquisition

Literature regarding CSII and CGM was reviewed.

Evidence Synthesis

Management of DM aims to regulate blood glucose to prevent long-term microvascular and macrovascular complications. CSIIs combined with CGMs provide an integrated system to maintain tight glycemic control in a safe and uninterrupted fashion, while minimizing hypoglycemic events. Recent advances have allowed to “closing of the loop” by better mimicking endogenous insulin secretion and glucose level regulation. Evidence supports sustained improvement in glycemic control with reduced episodes of hypoglycemia using these systems, while improving quality of life. Ongoing work in delivery algorithms with or without counterregulatory hormones will allow for further layers of regulation of the AP.

Conclusion

Ongoing efforts to develop an AP have created effective tools to improve the management of DM. CSIIs and CGMs are useful in diverse populations ranging from children to older individuals, as well as in various clinical contexts. Individually and more so together, these have had a tremendous effect on the management of DM, while avoiding treatment fatigue. However, cost and accessibility are still a hindrance to its wider application.
Non-Destructive Composition Identification for Mixtures of Iron Compounds Using a Chemical Environmental Effect on a Muon Capture Process
Authors: Ninomiya Kazuhiko , Kajino Meito , Nambu Akihiro , Inagaki Makoto , Kudo Takuto , Sato Akira , Terada Kentaro , Shinohara Atsushi , Tomono Dai , Kawashima Yoshitaka , Sakai Yoichi , Takayama Tsutomu
Published: December 2022

The non-destructive investigation of the chemical state of elements within a material is urgently needed in various scientific research fields. In recent years, non-destructive elemental analysis methods using muons have been developed. These methods identify elements by measuring muonic X-rays emitted from muonic atoms formed by the muon irradiation of the material. Interestingly, muonic atom formation processes are slightly influenced by the chemical state of the muon-capturing atom, and as a result, the muon capture probability of each element and the muonic X-ray emission intensity change depending on the chemical state. By utilizing this effect, it may be possible to know the chemical state at the same time as elemental analysis. In this study, the compositions of γ-Fe2O3 and Fe3O4 in an ironsand sample were determined using two approaches: muonic X-ray intensity ratios and muon capture ratios. The mixing ratios obtained from the two approaches were consistent with each other and consistent with results of the Mössbauer technique, a completely different analysis method. In this study, non-destructive chemical state analysis using muons was successfully demonstrated, and this method is promising for applications in various research fields.
Composite Formation of Anthrylene- and Ferrocenoyl-Substituted Phenyleneethynylenes with Single-Wall Carbon Nanotubes (SWCNTs)
Authors: Watanabe Hikaru , Ekuni Kento , Okuda Yasuhiro , Nakayama Ryo , Kawano Keisuke , Iwanaga Tetsuo , Yamaguchi Atsushi , Kiyomura Tsutomu , Miyake Hideaki , Yamagami Masahiro , Tajima Tomoyuki , Kitai Takumi , Hayashi Tomoya , Nishiyama Naoto , Kusano Yoshihiro , Kurata Hiroki , Takaguchi Yutaka , Orita Akihiro
Published: December 2022

Anthrylene- and ferrocenoyl-assisted composite fabrication was achieved between visible-light absorbing anthrylene- and ferrocenoyl-substituted acetylenic dyes and single-wall carbon nanotubes (SWCNTs). The composite formation was confirmed via UV-Vis, Raman, mass, and XPS spectra analyses. In the UV-Vis absorption spectrum, the resulting dye-SWCNT composites showed bathochromic shifts ascribable to the π-π interaction. One-pot fabrication of the composite was also accomplished via Cu-catalyzed dimerization of anthrylene- and ferrocenoyl-substituted terminal ethyne and the subsequent adsorption of the resulting butadiyne dye to SWCNT. We confirmed that the dye-SWCNT composite dispersed in water by using amphiphilic poly(amidoamine)dendrimer could transfer an electron from 1-benzyl-1,4-dihydronicotinamide (BNAH) to methyl viologen dichloride (MV2+) upon irradiation with visible light (>422 nm).
Manual annotation of Drosophila genes: a Genomics Education Partnership protocol
Authors: Rele Chinmay P. , Sandlin Katie M. , Leung Wilson , Reed Laura K.
Published: December 2022

Annotating the genomes of multiple species allows us to analyze the evolution of their genes. While many eukaryotic genome assemblies already include computational gene predictions, these predictions can benefit from review and refinement through manual gene annotation. The Genomics Education Partnership (GEP; https://thegep.org/) developed a structural annotation protocol for protein-coding genes that enables undergraduate student and faculty researchers to create high-quality gene annotations that can be utilized in subsequent scientific investigations. For example, this protocol has been utilized by the GEP faculty to engage undergraduate students in the comparative annotation of genes involved in the insulin signaling pathway in 27 Drosophila species, using D. melanogaster as the reference genome. Students construct gene models using multiple lines of computational and empirical evidence including expression data (e.g., RNA-Seq), sequence similarity (e.g., BLAST and multiple sequence alignment), and computational gene predictions. Quality control measures require each gene be annotated by at least two students working independently, followed by reconciliation of the submitted gene models by a more experienced student. This article provides an overview of the annotation protocol and describes how discrepancies in student submitted gene models are resolved to produce a final, high-quality gene set suitable for subsequent analyses. The protocol can be adapted to other scientific questions (e.g., expansion of the Drosophila Muller F element) and species (e.g., parasitoid wasps) to provide additional opportunities for undergraduate students to participate in genomics research. These student annotation efforts can substantially improve the quality of gene annotations in publicly available genomic databases.