bluuebunny/crossref_metadata_2025 huggingface dataset:
Proprioception assessment in stroke rehabilitation: A survey of Australian physiotherapists and occupational therapists
Authors: Fisher Georgia , de Oliveira Camila Quel , Rochette Annie , Gandevia Simon C. , Kennedy David S.
Published: November 2022

BACKGROUND: Proprioception is the awareness of the position, movement, and muscular force generated by the body and its musculoskeletal parts, and is an important somatosensory impairment to assess in people with stroke. We know that rehabilitation clinicians self-report to assess proprioception in approximately two-thirds of people with stroke. What we do not know is what type of assessments are used, or the true frequency of their use in clinical practice. This study aimed to provide a preliminary description of the type and frequency of proprioception assessment used by clinicians working in stroke rehabilitation in Australia, and their knowledge about proprioception impairment. METHODS: We surveyed Australian physiotherapists and occupational therapists who were involved in the rehabilitation of people with stroke. The online cross-sectional survey ran from March to October 2020. While they were blind to the aims of the study, respondents answered questions about clinical decision-making in a case study of a person with stroke and proprioception impairment. Then, they were asked questions about proprioception. RESULTS: There was a total of 165 survey responses, of which 58 contained complete datasets suitable for analysis. Only 55% (n = 32) of respondents selected an assessment of proprioception for the person described in the case study. The majority of respondents defined proprioception to be the sense of joint / limb (n = 38, 65.5%) or body (n = 27, 46.6%) position and used ‘eyeball’ judgements of limb matching accuracy (56%, n = 33) as an assessment. CONCLUSIONS: These preliminary data suggest that proprioception is likely under-assessed in stroke rehabilitation and that clinicians understand proprioception to be the sense of joint position and movement, but lack awareness of other proprioceptive senses, such as the sense of muscle force. These factors may reduce the ability of clinicians to rehabilitate proprioception impairment in people with stroke.
Changing chiropractic’s subluxation rhetoric: Moving on from ‘deniers’, ‘vitalists’, and ‘unorthodox’, to realists, post-realists, and absurdists
Authors: Ebrall Phillip
Published: November 2022

Chiropractic rhetoric must advance beyond vitalists attacking subluxation deniers, and deniers holding firm to eminence over evidence. I am calling for clear and strong debate in which the issues and their evidence are examined in the manner of traditional philosophical debate.

The purpose of this paper is to present two behaviours that will each change the profession and discipline’s narrative about subluxation, scilicet: (i) that an active, intellectual discussion occur and (ii) that it be published in any author’s preferred journal of record, indexed by the Chiropractic Library Collaboration with terms that will connect the papers, and be open access for all.

To facilitate this change I present a palette of three terms with exposition to show how we can build our rhetoric into constructive argument from either a realist, a post-realist, or an absurdist view-point.

For the reason the post-realist and absurdist’s positions are opinion, have not been thought-through, and show no appreciation of the paradox that they have no evidence at all supportive of that opinion, they should cease gaslighting the realists and anyone who opposes their position.

Chiropractic realism is the conventional position of the majority of the profession and of the discipline. The realists quite rightly demand to see and discuss the evidence, if any, held by the post-realists for their position.
Edukasi Strategi Pendampingan Belajar dari Rumah untuk Membangun Situasi Belajar Kondusif di Lingkungan Candi Baru, Gianyar
Authors: Sukaningsih Ayu , Kadek Devi Kalfika Anggria Wardani  , A.A. Ngr. Eddy Suriyadinata Gorda
Published: November 2022

Since December 2019, the world has been shocked by the Covid-19 virus which can be transmitted through small droplets that come out when sneezing from the nose or mouth of people who are infected with the virus. To break the chain of spreading this virus, the government enforces a rule that all activities are carried out from home, including learning activities. Through community service activities carried out by this author, it aims to determine the effectiveness of online learning mentoring education for parents whose children are following the online learning process from home, so as to reduce the difficulties of parents when accompanying their children to learn from home. The target partners of this service are several communities whose children study online at home in the Candi Baru neighborhood, Gianyar. The method used in this study is the PAR research method, which is a method that emphasizes the participation and collaboration of various parties in managing a research. This research shows that the provision of online learning mentoring education can increase parents' knowledge and understanding of online learning.
Implementasi Sistem Informasi Akuntansi Dan Administrasi Berbasis Digital
Authors: Alfian Mohammad , Kartika Dewi , Ferida Arifany
Published: November 2022

Villages have the opportunity to develop their potential since the enactment of the Village Law. Optimizing the potential of the village is used for the benefit of the village community. The purpose of optimizing the potential of the village is to improve the lives of the village community. The purpose of establishing Village-Owned Enterprises (BUMDes) is one of the government's efforts to drive the village economy. BUMDes is expected to be a locomotive for the movement of the village economy that can make the village prosperous and reduce poverty. For this goal to be achieved, BUMDes needs to be managed professionally so that they can compete and develop properly. BUMDes Bangun Ber Bersama is a BUMDes in Kepunduhan Village, Tegal Regency. BUMDes Bangun Bersama has the full support of the local village government. BUMDesa Bangun together has limited capabilities of existing human resources. The limitation of existing human resources is the ability in financial reporting operational activities. This Community Partnership Program (PKM) aims to provide financial management methods from manual to systematic and digitalized based on Google Suite. The output of the activities carried out is that BUMDes administrators understand the Bumdes administration system and accounting/bookkeeping and have the ability to make BUMDes Financial Statements in the form of simple accounting, namely making daily cash books, balance sheets, profit and loss reports, and digital-based and systematic capital change reports.
Penerapan E-Marketing Dalam Upaya Meningkatkan Pendapatan Pada Wisata Danau Shuji Lembak Kabupaten Muara Enim
Authors: Azizah Afiah , An Nafisah Sabita , Hafizh Muhammad , Rima  , Renaldo Muhammad , Afif Muhammad , Anggraini Leriza , Ratu Mutiara , Purnamasari Endah
Published: November 2022

Desa Lembak memiliki potensi perekonomian yang bergerak dibidang pariwisata yaitu objek wisata alam Danau Shuji yang menjadi salah satu destinasi wisatawan lokal di daerah Sumatera Selatan. Pemanfaatan teknologi informasi sangat dibutuhkan di sektor pariwisata guna mendorong perekonomian daerah.Fasilitas yang dikembangkan pada industri pariwisata ini yaitu menggunakan sebuah konsep E-Tourism. E-Tourism adalah sebuah konsep teknologi informasi yang dikembangkan pada industri pariwisata. Tujuan dilakukan survey lokasi objek wisata Danau Shuji tidak lain untuk mengetahui icon wisata, sejarah atau pun tarif dari berbagai fasilitas yang terdapat pada Danau Shuji. Untuk menarik minat wisatawan lokal luar kota maka dibuatlah sebuah scan barcode yang bertujuan untuk memudahkan penyampaian informasi terkait sejarah, harga tiket dan hiburan serta petunjuk jalan berupa link yang terhubung pada maps. Pembuatan Blog yang di akses menggunakan scan barcode merupakan suatu bentuk pemanfaatan teknologi informasi yang akan terus berkembang.
Implementasi aplikasi order penjualan online berbasis android pada UMKM Surya Jenangan di desa Jenangan Kecamatan Jenangan Kabupaten Ponorogo
Authors: Sari Chanif , Pandowo Hedi
Published: November 2022

Salah satu sektor yang sangat terpukul oleh pandemi Covid-19 adalah Usaha Mikro, Kecil, dan Menengah (UMKM), yang juga menyumbang turunnya perekonomian nasional. Hal ini bisa dipahami karena UMKM mempunyai kontribusi yang sangat besar dalam perekonomian nasional. Kementerian Koperasi dan UKM mencatat hingga Februari 2022 sudah 17,25 juta pelaku UMKM yang terhubung ke dalam ekosistem digital. Sedangkan menurut data dari Kompas.com  pengguna internet di Indonesia pada awal 2022 ini dilaporkan mencapai 210 juta jiwa. Dari jumlah ini, mayoritas pengguna mengakses internet lewat ponsel untuk membuka media sosial. Oleh karena itu penting sebagai pelaku bisnis untuk menggunakan tools berupa aplikasi online berbasis android salah satunya untuk digunakan sebagai media transaksi bisnisnya. UMKM surya jenangan merupakan salah satu pelaku bisnis dibidang perdagangan barang-barang kelontong yang masih menggunakan cara bisnis konvensional yaitu transaksi yang mensyaratkan antara penjual dan pembeli harus bertemu secara fisik untuk melakukan transaksi jual beli. Tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan pelatihan dan implementasi menggunakan aplikasi berbasis android  untuk meningkatkan omzet penjualan
Quantitative and qualitative analysis of higher-order thinking skills in blended learning
Authors:   Hunan University of Technology and Business, He Xiangjun , Singh Charanjit Kaur Swaran ,   Universiti Pendidikan Sultan Idris, Ebrahim Nader Ale ,   University of Malaya
Published: November 2022

The problem and the aim of the study. Higher-order thinking skills is a very popular concept in education field around the world. Among the broad range of higher-order thinking skills, recent studies are concentrating on fostering higher-order thinking skills in education. The number of related publications demands a bibliometric study for finding the keywords, sources, countries, and research clusters. And the study carried out a bibliometric analysis of the relevant publications on higher-order thinking skills from Scopus database between 2011 and 2020. Research methods. A visual system of top keywords in higher-order thinking skills research has been produced by analyzing of keywords co-occurrence. And by using bibliography inquiry, the most common topic of blended learning has been found. This study also investigates the recent publication trend of higher-order thinking skills in blended learning. Results. The annual number of publications demonstrates an uptrend in the area of higher-order thinking skills, and the publication rates have increased distinctively in 2018 and 2019. Indonesia and the United States have already become the two major research centers while Malaysia and Australia are joining the research circle in the near future. Related publications had been related to the field of education and metacognition from the very beginning in 2016, and then to the field of higher education, critical thinking and assessment, followed by active thinking and learning in 2017, and eventually to blended learning and flipped classroom in 2018. The systematic structure shows that the United States and Korea have more papers from joint efforts than other countries. In particular, Korea became the most collaborative country. The Journal of Physics: Conference series has signified an increasing occurrence in publications on Higherorder thinking skills in blended learning with “student” acting as the most influential word. Fostering higher-order thinking skills cultivation in flipped classroom and scaffolding higher-order thinking skills activities in learning approaches are both crucial areas involved. In conclusion, the quantitative analysis on higher-order thinking skills through bibliometric study has revealed the recent subfield of blende learning. Thus, the dataset is further refined by blended learning, considering publication year, sources, countries and organizations, keywords and topics. The annual output of publications on higher-order thinking in blended learning have risen in the past ten years, showing it is more likely to keep developing in the near future.
Age aspect of the subjective well-being of modern youth
Authors:   North Caucasus Federal University, Banshchikova Tatiana N. , Sokolovskii Maksim L. ,   North Caucasus Federal University
Published: November 2022

The subjective well-being problem in the context of the influence of uncertainty, the personal dispositions leading role and regulatory resources of modern youth is becoming an extremely significant task and a global challenge of modern society. The purpose of this study was to identify significant predictors of the subjective well-being of young people of different age groups. At the first stage, a comparative analysis of well-being predictors was carried out. The study involved 1435 respondents aged 18 to 35 years. The average age is 20.7. The study used: a Shamionov’s and Beskova’s method for diagnosing the subjective well-being of the personality; Morosanova’s “Self-regulation Profile Questionnaire - SRPQM 2020”; tolerance / intolerance to uncertainty questionnaire by Kornilova and Chumakova; short version of the Big Five Personality Questionnaire, MiniIPIP. For data analysis, one-way analysis of variance, regression analysis, and Student’s t-test were used. At the second stage, regression models of subjective well-being were built for four age groups and their comparative analysis was carried out. Subjective well-being, social-normative well-being, and uncertainty tolerance decrease between 16 and 24 years of age and rise again for the 25-35 age group (p<0.01), except for uncertainty tolerance, which remains at the level of 22-24 age group (p<0.0001). The universal predictors of subjective well-being according to the results of regression analysis were persistence β = [0,278; 0,505] and neuroticism β = [-0,318; -0,197]. With age, the structure of regression models becomes simpler: from 7 parameters for subjects aged 16-18 (R2 = 0.57) to three parameters for the sample of 25-35 (R2 = 0.58). The results obtained can be used in educational work with young people to create psychological conditions for a conscious active attitude to the surrounding reality through the development of the ability to consciously regulate one’s activities and behavior and develop a tolerance for uncertainty
The use of game mechanics in the professional training of future teachers in working with gifted children
Authors:   Vyatka State University, Soboleva Elena V. , Matveev Vladimir V. ,   Orel State Institute of Culture, Annenkova Alla A. ,   Orel State Institute of Culture, Boyarintseva Natalya A. ,   Vyatka State University, Gribkov Dmitry N. ,   Orel State Institute of Culture
Published: November 2022

The problem and the aim. One of the priorities of modern society is to create conditions conducive to the identification and development of gifted children. The training of teachers, during which the professional competencies of students are expanded to diagnose, support the abilities and talents of students, including those with special educational needs, takes place within the framework of the corresponding master's program. The purpose of the article is to investigate the impact of the use of game mechanics in the training of undergraduates, future experts in working with gifted children, on the quality of their professional training. Research methods. Authors described implementation of the game mechanics "Achievement", "Joint research", "Constraints", "Fun once – fun always", "User progress". Digital services for the gamification of education: visual designer Kodu Game Lab, virtual boards, random selection generators. 44 undergraduates of Vyatka Humanitarian University in the field of Pedagogical education are involved. Pedagogy of giftedness. Practice bases: schools, centers for the development of talented children, Orel State Institute of Culture. For additional research of students' opinions on the influence of game mechanics (on education in general, on work with gifted children, on professional development), the authors have developed a special questionnaire. The survey was performed in the MS Teams environment. The average age of respondents was 24 years (80% of girls and 20% of young people). Pearson’s criterion χ2 (chi-squared) was used for statistical data processing. Results. Gamification of the activities of undergraduates of the experimental group is presented as in the "not computer-based" form (business or board game, research project, etc.) and in the Kodu Game Lab environment. A questionnaire has been developed from three blocks: "Game mechanics in education", "Game mechanics for the development of students, including those with special educational needs", "Game mechanics for the professional development of a teacher". Statistically significant differences in the qualitative changes in the pedagogical system were revealed, χ2 observ. 2 > χ2 critic0.05 (6,71 > 5,99). In conclusion, the directions of modernization of the training of undergraduates, future teachers to work with gifted children are described, in accordance with the results of the survey.
A relação entre os resíduos sólidos das construções civis e a sustentabilidade
Authors: Silva Wesley Vinícius da , Santos Wendell José Soares dos
Published: November 2022

A relação entre construção civil e sustentabilidade está ligada à quantidade de resíduos sólidos descartados indevidamente após construções civis, onde isso prejudica significativamente o meio ambiente. Diante do que foi exposto, surgiu a seguinte questão norteadora da pesquisa: quais são os desafios enfrentados pela engenharia civil no tocante à suscetibilidade de construções mais sustentáveis e os instrumentos necessários à eficácia dessas novas medidas em prol do meio ambiente na redução de resíduos sólidos? Assim, o presente trabalho objetiva apontar a relação entre construções civis e sustentabilidade, destacar medidas mitigadoras da geração de resíduos sólidos de construção civil expostos ao meio ambiente, além de discutir o que as consequências do desrespeito às normas e diretrizes sobre descartes podem causar a um país. Esta é uma revisão integrativa, a qual estabelece a síntese de artigos científicos que versam sobre o tema escolhido, extraídos das bases de dados SciELO e Google Acadêmico, publicados nos últimos 12 anos (período entre 2010 e 2022). Os resultados aqui apontados demonstram que as empresas construtoras pouco investem em medidas mitigadoras, dificultando a redução da geração de resíduos sólidos de construções civis. Concluiu-se que é necessária a intervenção governamental a fim de mudar esta realidade através de viabilidade nos investimentos necessários, bem como na maior aplicabilidade de suas leis.
Effect of Processing Parameters to The Fish Oil from Fish Waste Via Modified Soxhlet Extraction
Authors: MOHD SAID FARHAN BINTI
Published: November 2022

The oil production and fatty acid methyl ester (FAME) contents of fish waste were studied. Solvent, temperature, and extraction time were the processing parameters involved. The oil and FAME were extracted using a modified soxhlet extraction method. The best solvent for fish oil extraction was found to be ethanol, which yielded 49.0%, followed by ethanol:heptane (1:1), methanol:heptane (1:1), and methanol. The oil extract composition contained a high yield of oleic acid (C18:1), ranging from 42% to 66%. Followed by palmitic acid (C16:0), palmitoleic acid (C16:1), and stearic acid (C18:0). According to the statistical model obtained, at the 95% confidence level, extraction time had a significant effect on both oil and oleic acid yield (C18:1). These results demonstrated that a high oleic acid fraction can be obtained from fish waste with ethanol, implying that there is a high potential for cost-effective biofuel production.
E-SuKet: Peningkatan Kualitas Layanan Desa Tenggarang Kecamatan Tenggarang Kabupaten Bondowoso melalui Implementasi Layanan Surat Keterangan Berbasis Elektronik
Authors: Putra Januar Adi , Prasetyo Beny , Ariefianto Lutfie
Published: November 2022

Pelayanan publik yang baik bagi seluruh masyarakat merupakan tuntutan yang harus dipenuhi oleh seluruh lembaga pemerintahan. Hal ini sebagai bagian dari perwujudan tata kelola pemerintahan yang baik (good government governance). Berdasarkan data yang dihimpun oleh Lembaga Penelitian dan Pengabdian Masyarakat(LP2M) Universitas Jember (UNEJ), Desa Tenggarang yang terletak di Kecamatan Tenggarang Kabupaten Bondowoso memiliki beberapa masalah yang berkaitan dengan kualitas pelayanan publik bagi masyarakat. Tidak adanya media sebagai wadah pengaduan keluhan/aspirasi masyarakat & pengurusan surat izin/keterangan yang masih dilakukan dengan cara manual membutuhkan waktu lama. Kondisi ini membuat permasalahan yang dialami warga tidak dapat tertangani dengan baik. Jarak pemukiman antar warga dan dengan balai desa cukup jauh. Hal ini menyebabkan masyarakat malas untuk menyampaikan permasalahan / aspirasinya karena dibutuhkan usaha yang cukup besar untuk mencapai balai desa, pengurusan surat izin yang masih dilakukan secara manual juga sangat menyita waktu masyarakat. Sementara disisi lain banyak kebutuhan pada masyarakat perlu penanganan/respon yang cepat
The Effect of Elevated Temperature on Ordinary Portland Cements
Authors: Fehérvári Sándor
Published: November 2022

A study was directed to analyze the influence of the different types of Ordinary Portland Cements (OPC) on the hardened cement paste exposed to high temperatures. Hardened cement paste specimens with three types of cement and nine water-cement ratios were investigated and heated to 11 heat steps at 28 days of age. Residual compressive strength and relative residual compressive strength were compared to the unheated results. It was shown that the expected range for the relative residual strength of the different types of OPC up to 400 °C is between 90 and 100%. From the local minimum at 150 °C to the maximum at 300 °C. The CEM I 52.5 type of cement shows the least favorable behavior to the increased (over 400 °C) temperature, according to the results of the residual compressive strengths curves and the newly introduced Integrated Temperature Endurance values after the first water-cement ratio (0.3). Nine water-cement ratios were tested with the favorable types of OPC (CEM I 42.5 and CEM I 32.5). At all water-cement ratios, the residual strength tendencies for the two types of cement were parallel. It has been observed that changes in the water-cement ratio have little to no impact on the relative strength curve's shape or the relationship between strength and the water cement ratio. As a result of our experiments applying simply Ordinary Portland Cement, it is obvious that the CEM I 32.5 type of OPC cement significantly outperformed the CEM I 42.5 type in regards of post-heating strength tendencies.
Uluslararası Yatırım Tahkiminde Vatandaşlık Meselesine (Yeniden) Bakış: Serafin Garcia Armas v Venezuela
Authors: BOLACA Aysun
Published: November 2022

Uluslararası yatırım tahkiminde yatırımcının vatandaşlığının tespiti kritik bir öneme sahip- tir. Çünkü tahkimin kalbi olan yetki meselesi, vatandaşlık esasına göre saptanır. Yatırımcının, iki taraflı veya çok taraflı uluslararası yatırım antlaşmalarında kararlaştırılan koruma standartların- dan yararlanabilmesi ve söz konusu koruma standartlarının ihlali durumunda yatırıma ev sa- hipliği yapan Devlete karşı tahkim yargılamasına başvurabilmesi için ise ‘yabancı’ olma niteli- ğini haiz olması gerekmektedir, bir diğer ifadeyle, yatırımcının yatırım yaptığı devletin vatan- daşı olmaması şartı gözetilir. Uygulamada, yatırımcının aynı zamanda iki veya daha fazla va- tandaşlığa sahip olduğu durumlarda uluslararası yatırım tahkimine ilişkin bazı soru(n)larla karşılaşılabilmektedir. Örneğin yatırıma ev sahipliği yapan Devletin de vatandaşlığını taşıyan yabancı yatırımcının (çifte vatandaşlığı bulunması durumunda), ilgili yatırım antlaşmasına dayanarak kendi devletine karşı uluslararası tahkim prosedürünü başlatıp başlatamayacağı meselesi bu soru(n)ların başında gelmektedir.

Bu çalışma, antlaşma-temelli yatırım tahkiminde çifte vatandaşlığa sahip yatırımcının kendi devletine karşı tahkim prosedürünü başlatmasına geçit veren (yayınlanmış) ilk uluslara- rası tahkim kararını, Serafin Garcia Armas v Venezuela, inceleyecek ve bu kararın uluslararası yatırım tahkimi bakımından önemini, sonucunu ve gelecekteki tahkim uyuşmazlıklarına ilişkin verilecek kararlar üzerindeki olası etkilerini tartışacaktır.
IL-10 does not affect oxidative burst and expression of selected surface antigen on human blood phagocytes in vitro.
Authors: Gallová L , Kubala L , Číž M , Lojek A
Published: November 2022

Cytokines play a major role in the control of inflammatory responses, participate in the regulation of blood phagocyte activities and as such are used for immunomodulatory therapy. In the present study, the influence of IL-10 on human blood phagocyte activity in the presence/absence of IL-6, IL-8 and TNF-a was tested in vitro. Our research analyzed the effects of cytokines on the production of reactive oxygen species measured by chemiluminescence and flow cytometry, and on the expression of surface molecules (CD11b, CD15, CD62L, CD31) measured by flow cytometry. IL-10 had no inhibitory effect on reactive oxygen species production and the expression of any examined adhesion molecule by resting or stimulated blood phagocytes within 3 h of incubation. Conversely, TNF-, IL-6, and IL-8 increased reactive oxygen species production and the expression of CD11b and CD15 on both neutrophils and monocytes and decreased the expression of CD62L. These priming effects of the tested pro-inflammatory cytokines were not affected by IL-10. The obtained results suggest that IL-10 does not directly control blood phagocyte activation. These results also provide better information about the contribution of IL-6, IL-8 and TNF- to the regulation of blood phagocyte-mediated inflammatory processes.
Lipid peroxidation and nutrition.
Authors: Krajčovičová-Kudláčková M , Spustová V , Pauková V
Published: November 2022

Levels of conjugated dienes of fatty acids (first peroxidation product) in relation to their substrates and promotors (triacylglycerols, homocysteine, iron) as well as to their inhibitors (essential antioxidative vitamins) were assessed in a vegetarian group (n=24) and compared with subjects on a mixed diet (traditional nutrition, n=24). Positive significant linear correlation between conjugated dienes and triacylglycerols, homocysteine, iron as well as inverse relationship between conjugated dienes and vitamin E, vitamin C, beta-carotene were observed in pooled groups. Lipid peroxidation risk in vegetarians seems to be caused predominantly by hyperhomocysteinemia, whereas in a mixed diet group this was due to a higher supply of substrates or risk iron values. The incidence of only 8 % of risk conjugated diene values in vegetarians in contrast to 42 % in the group with traditional diet indicates that vegetarians have a better antioxidative status as a consequence of regular consumption of protective food.
New Frontiers in Chronic Obstructive Pulmonary Disease: Where Are We Heading?
Authors: Agustí Alvar , Christenson Stephanie , Han MeiLan , Singh Dave
Published: November 2022

This symposium took place during the 2022 meeting of the European Respiratory Society (ERS). Focusing on new frontiers in chronic obstructive pulmonary disease (COPD), the speakers discussed the current understanding of the heterogeneity of COPD, the spectrum of inflammatory pathways in COPD pathophysiology, and the evolving clinical landscape in COPD. Alvar Agustí, Professor of Medicine at the University of Barcelona, Spain, introduced the concept of a gene, environment, and time (GETomic) perspective of COPD, ending with the trajectome, or range of lung function trajectories, through the lifespan. Stephanie Christenson, Assistant Professor of Pulmonology at the University of California, San Francisco, USA, followed by exploring the role of inflammation in COPD, highlighting that it is a heterogeneous disease with broad inflammatory pathways. This includes types 1, 17, and 2 inflammation; a wide range of immune effector cells beyond eosinophils; and key cytokines such as IL-33, IL-4, IL-13, and IL-5, which mediate the pathophysiology of COPD in response to cigarette smoke and other environmental insults. The need for continued investigation of molecular phenotypes was expanded on further by MeiLan Han, Professor of Medicine at the University of Michigan, Ann Arbor, USA, who explored the knowns and unknowns in the standard-of-care management of patients with COPD, highlighting the evolving understanding and identification of disease endotypes and phenotypes; poor understanding of COPD disease progression; the importance of smoking status in response to currently available treatments; and significant unmet need for additional treatment, even among patients on triple therapy. Dave Singh, Professor of Respiratory Pharmacology at the University of Manchester, UK, then discussed active areas of investigation in the development of additional treatments for patients with COPD.
Designing Preferential Rules of Origin for the AfCFTA: Addressing Pre-Existing Challenges at the Regional Level
Authors: Ndonga Dennis , Laryea Emmanuel
Published: November 2022

African countries are still negotiating the RoO for AfCFTA. Rules of Origin (RoO), a mechanism for determining the economic nationality of a product, are an essential part of international trade due to their use in the enforcement of preferential treatment of goods. AfCFTA member states seek to build upon RoO under their existing RECs. However, the design and implementation of RoO under the various RECs are seen as one of the obstacles to intra-Africa trade. This article examines the RoO of Africa’s key RECs, namely the EAC, COMESA, ECOWAS, SADC and the TFTA, with a view to drawing out lessons, the drawbacks that need to be addressed or avoided, and shaping the RoO of the AfCFTA to enhance the achievement of its objective of promoting intra-African trade.
Deconstructing the Dominant Human Rights Grammar: An Alter-Native Narrative based on Indigenous Peoples’ World-Views
Authors: Gómez-Sánchez Davinia
Published: November 2022

This article contests the dominant ethnocentric Human Rights grammar and proposes a decentred alternative by focusing on the legal epistemologies of Southern African Indigenous Peoples.

Increasing inequalities, aggravated poverty, environmental degradation, unsustainable life-styles and socio-cultural polarisation are compelling challenges that demand approaches grounded on new narratives, beyond the framework provided by Western centric theorisation, binary logic, the individual liberal human rights paradigm and neo-liberal development and justice models.

The cultural specificity of human rights as well as their rise as normative instruments and assertions of universal entitlements, stripped human rights off the political and transformative potential to challenge the economic, social and political structures at the core of the imbalances they aim at remedying. In an attempt to transcend the limitations of the current hegemonic human rights paradigm (centred on the individual, rights and legalistic approaches), the proposal advanced here aims at reclaiming and recapturing the insights and values of African Indigenous Peoples as intellectual capital to reconfigure the prevailing human rights discourse. This article strives to rework and enlarge the notion and content of human rights with elements from counter hegemonic alternative world-views informed by peripheral knowledge(s), subaltern legalities and epistemologies. It seeks to revert epistemic injustice by formulating an alter-native narrative based on Indigenous Peoples’ world-views.
Administration of Value Added Tax (Goods and Services Tax) and Fiscal Federalism in Nigeria: Lessons from Australia, Canada, the USA, India and Ethiopia
Authors: Richards Newman U.
Published: November 2022

One of the incidences of federalism is that taxing powers are shared between the federating units. Thus fiscal federalism affects the administration of consumption taxes in federal systems. The implication of fiscal federalism under the Nigerian constitution on consumption taxes has generated some controversies over the years. The question has been whether the constitution allows a dual level administration of consumption taxes by the federal and states governments or whether the powers are solely vested in the federal government. This article argues that there is a hiatus in the constitution as it is unclear who has the powers to impose consumption taxes in Nigeria. The article will propose necessary constitutional amendment drawing from the lessons the experiences other federal systems like Australia, Canada, the United States of America, India and Ethiopia present.
Implementation of the Decisions and Judgments of African Regional Human Rights Tribunals: Reflections on the Barriers to State Compliance and the Lessons Learnt
Authors: Ayeni Victor Oluwasina
Published: November 2022

There are three main regional human rights tribunals (HRTs) in Africa, namely the African Commission, the African Court and the African Committee of Experts on the Rights and Welfare of the Child. In addition to these, there are political bodies within the African Union responsible for implementing human rights mandates as well as several sub-regional courts established for the primary purpose of adjudicating trade disputes and facilitating political integration which have issued notable human rights decisions and judgments. Accordingly, Africa is not lacking in human rights jurisprudence. What is lacking, however, is genuine commitment on the part of state actors to implement the decisions and judgments of the various human rights bodies. This article examines the factors responsible for slowing down the pace and rate of state compliance in Africa. It argues, among other things, that compliance with HRTs' decisions in Africa has been limited due to poor supervision mechanisms, weak domestic infrastructures, weak state institutions caused by 'strong men syndrome' and poor observance of the rule of law, poor institutional designs of regional and sub-regional HRTs, lack of awareness and erroneous perceptions about international human rights system, ineffective follow-up as well as a poor system of governance in many states in Africa among other factors. The article notes that attitudinal barriers and erroneous perceptions about international human rights system are central to the various barriers and thus adequate attention should be given to changing negative attitudes and perceptions among states actors and members of the public in the various African states.
Nostalgia, Melancholy, Trauma: Backlash Postfeminism in Contemporary French Screen Romance
Authors: Harrod Mary
Published: November 2022

This article draws on Diane Negra’s (2009) assessment of neo-global postfeminist popular culture and cinema as displaying an obsession with time-control that is largely inimical to feminist progress, arguing that similar currents are visible in 2010s French screen romances. While manifestations of this obsession with relevance for the contemporary French context range from celebrations of ritualized, time-sensitive milestones (marriage, pregnancy) to narratives of female professional retreatism in the face of ‘time-poverty’ or the expansion of sexualized female identities across ages, this article focuses in depth on themes of actual or symbolic historical reversion in the intimate sphere through a close analysis of the films Camille redouble (Noémie Lvovsky, 2012) and Un peu, beaucoup, aveuglément (Clovis Cornillac, 2015). After surveying other cognate fictions, the discussion demonstrates that both these films reflect a wider backdrop of time-related trauma informing contemporary French onscreen romance and are accordingly melancholic, as well as openly nostalgic, in theme and tone. The article interrogates the backlash aspects of such narratives but also the different resonances associated with regressive ‘postfeminist’ elements in French as opposed to American culture. It thus demonstrates that postfeminism bears a specific relationship to the distinctive past history comprised by local feminist movements and intersects with other Gallic customs and ideologies – notably nationalistic ones – in particular ways.
Biochemical Study of Cyano-(3-Phenoxyphenyl)Methyl (1s,3s)-3-((Z)- 2- Chloro-3,3,3-Trifluoroprop-1-Enyl)-2,2-Dimethylcyclopropane-1- Carboxylate (Lambda Cyhalothrin Pyrethroid Insecticide Resistance) on Aedes aegypti
Authors: Jebastin M. Jas Sonia , Abirama G Sundari , David S Roshan , Jacquline P Rosy
Published: November 2022

By using the melt emulsified homogenization process, the nanosuspended Lambda-cyhalothrin with the least number of surfactants was created. Powder X-ray diffraction, Scanning Electron Microscopy, and Mass Spectroscopy were used to analyse the material. Their exceptional physical and chemical stability supports the nanoparticles' stable crystalline state. Nano Lambda-cyhalothrin increased pesticide absorptivity, biological activity, and efficiency while reducing poor solubility. It is effective to use lambda-cyhalothrin as larvicides to inhibit Aedes aegypti larvae. Public health is impacted by mosquito-borne illnesses, which also place a significant strain on the global economy and development. Because of their propensity to nest within human habitations and spread arboviral infections, Aedes species haa a tight relationship with people. The metabolic resistance of enzyme detoxification in diverse resistant strains of Aedes aegypti was determined by lambda-biochemical cyhalothrin's activity.
Assessment of Ulva lactuca Extract on Inflammatory Markers in Fructose Fed Experimental Rats
Authors: T. Tamilarasi , T Malarvili , K Suganthi , V Sivaranjani
Published: November 2022

Adipose tissue controls energy homeostasis. Adipocytes secrete hormones and inflammation-related adipokines in addition to storing fat. Green seaweeds are a typical dietary element in Eastern Asian nations like India. They are rich in proteins, vitamins, minerals, fibre, polyunsaturated fatty acids, and bioactive compounds. This study examined Ulva lactuca extract's influence on hormones and anti-inflammatory markers in fructose-fed rats. High fructose-fed rats had elevated blood leptin, IL-6, TNF-, and decreased adiponectin and ghrelin. Ulva lactuca extract improved leptin, IL-6, TNF-, adiponectin, and ghrelin in obese rats. Ulva lactuca may restore adipose tissue function owing to saponin, steroids, alkaloids, polyphenol, and glycoside
Evaluation of Anti-Colorectal Cancer Activity in Methanolic Extract of Coleus forskohlii Root
Authors: Mary P Philomina , A Malarvizhi
Published: November 2022

In a multistage process that involves moving from a precancerous lesion to a malignant tumour state, cancer develops when normal cells undergo the change into tumour cells. Colon cancer, also known as colorectal cancer (CRC), is the third most common and second-deadliest malignant tumour in the world. The current study's objective was to assess the anticancer potential of a methanolic extract of Coleus forskohlii root on the cancer cell line HT-29 using the MTT assay. A variety of assay methods were used, including morphological investigations, cell growth inhibition, and cell viability. At various concentrations (12.5, 25, 50, 100, and 200 µg/ml), the Coleus forskohlii extract was tested against the HT-29 cell line for its ability to inhibit cell proliferation. This study revealed that when concentrations rise the cell growth inhibition levels rise. The conventional medicine Doxorubicin had a growth inhibition of 72.70% at a dose of 5 µg/ml while the lowest growth inhibition was determined to be 9.55% at 12.5 µg/ml and the highest growth inhibition was 71.16% at 200 µg/ml. IC50 was greater than 123.90 µg/ml. According to the study's findings, a human colon adenocarcinoma cell line could be resistant to the anti-colorectal cancer effects of Coleus forskohlii root methanolic extract (HT-29).
Effectiveness of Focused Counselling on Nipple Trauma and its Management Among Lactating Mothers
Authors: Priya D Berttle , G. Muthamilselvi
Published: November 2022

Exclusive breast feeding for 6 months is a universal and recommended by WHO andUNICEF. Most of the time, many mothers’ experiences painful feeding due to sore nipple or traumatized nipple. Nipple trauma is one of the leading causes to reduce the breast-feeding rate. Promoting the practice of proper breast-feeding techniques reduces the nipple trauma, thus promotes the wellness of infants by breast feeding exclusively. The main objective of this study was to explore the knowledge regarding nipple trauma and its management, impart the knowledge regarding prevention of nipple trauma among lactating mothers. One group pre- and post-test design was adopted. Primi para lactating mothers were selected through purposive sampling technique in selected hospital, Cuddalore, Tamil Nadu. The study revealed that 80% of mothers had inadequate knowledge, 20% had moderately adequate knowledge about nipple trauma and its management. 32.7% of mother belongs to the age group of 26-30 years. 45% of them are working in non-governmental sectors, 23 % of mother had complicated pregnancy. The value of demographic variables such as age, occupation, complications during antenatal period and intake of medication while pregnant had significant association, respectively (x2 = 12.2, x2 = 14.4, x2= 11.4 and x2 11.10) at the level of p≤0.001 and p <0.05. This study concluded that focusing on the problem with focused individual counselling promotes the breast feeding rate.
Silk fibroin scaffolds: A promising candidate for bone regeneration
Authors: Wu Hao , Lin Kaili , Zhao Cancan , Wang Xudong
Published: November 2022

It remains a big challenge in clinical practice to repair large-sized bone defects and many factors limit the application of autografts and allografts, The application of exogenous scaffolds is an alternate strategy for bone regeneration, among which the silk fibroin (SF) scaffold is a promising candidate. Due to the advantages of excellent biocompatibility, satisfying mechanical property, controllable biodegradability and structural adjustability, SF scaffolds exhibit great potential in bone regeneration with the help of well-designed structures, bioactive components and functional surface modification. This review will summarize the cell and tissue interaction with SF scaffolds, techniques to fabricate SF-based scaffolds and modifications of SF scaffolds to enhance osteogenesis, which will provide a deep and comprehensive insight into SF scaffolds and inspire the design and fabrication of novel SF scaffolds for superior osteogenic performance. However, there still needs more comprehensive efforts to promote better clinical translation of SF scaffolds, including more experiments in big animal models and clinical trials. Furthermore, deeper investigations are also in demand to reveal the degradation and clearing mechanisms of SF scaffolds and evaluate the influence of degradation products.
A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy
Authors: Yuan Wenxiu , Wu Yange , Huang Maotuan , Zhou Xueman , Liu Jiaqi , Yi Yating , Wang Jun , Liu Jin
Published: November 2022

Temporomandibular joint osteoarthritis (TMJOA) is a debilitating degenerative disease with high incidence, deteriorating quality of patient life. Currently, due to ambiguous etiology, the traditional clinical strategies of TMJOA emphasize on symptomatic treatments such as pain relief and inflammation alleviation, which are unable to halt or reverse the destruction of cartilage or subchondral bone. A number of studies have suggested the potential application prospect of mesenchymal stem cells (MSCs)-based therapy in TMJOA and other cartilage injury. Worthy of note, exosomes are increasingly being considered the principal efficacious agent of MSC secretions for TMJOA management. The extensive study of exosomes (derived from MSCs, synoviocytes, chondrocytes or adipose tissue et al.) on arthritis recently, has indicated exosomes and their specific miRNA components to be potential therapeutic agents for TMJOA. In this review, we aim to systematically summarize therapeutic properties and underlying mechanisms of MSCs and exosomes from different sources in TMJOA, also analyze and discuss the approaches to optimization, challenges, and prospects of exosome-based therapeutic strategy.
Optimization of experimental conditions of microbial desulfurization in coal mine using response surface methodology
Authors: Ai Chun‐ming , Sun Ping‐ping , Zhao Dan , Mu Xiao‐zhi
Published: November 2022

To reduce the risk of spontaneous combustion during coal storage and transportation, microbial desulfurization technology is used to reduce the content of inorganic sulfur in coal. A strain of Aciditithiobacillus ferrooxidans was purified from coal mine water in Datong, Shanxi Province, and its desulfurization test conditions were optimized. Taking the inorganic sulfur removal rate of coal as the response value. The Plackett-Burman design method was used to screen the main factors affecting the response value. And the response surface method was used to establish the continuous variable surface model to determine the interaction between the factors. The results show that the three main factors affecting the response value and their significance order are temperature > coal particle size > desulfurization time, and the interaction between temperature and coal particle size has the greatest effect. When the temperature is 29.50°C, the coal size is 100 mesh, and the desulfurization time is 11.67 days, the desulfurization effect is the best, and the removal rate of inorganic sulfur can reach 79.78%, which is close to the predicted value, and the regression effect is wonderful.