bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic Association of FTO gene variants (rs17817449 T>G and rs9939609 T>A) with obesity and its related Phenotypes in North Indian Punjabi Population
Authors: Sharma Tanmayi , Professor Badaruddoza
Published: March 2023

Fat mass and obesity associated (FTO) gene belongs to the non-heme Fe (II) and 2 oxoglutarate dependent dioxygenase superfamily. FTO gene has been evolved as a potent genetic risk factor for the development of obesity. To establish the potential association between FTO rs17817449 T > G and rs9939609 T > A polymorphisms and obesity risk in north Indian Punjabi population, a total of 333 obese and 338 non-obese control subjects were randomly selected. Both the FTO gene polymorphisms rs17817449 (TT vs GG: odds ratio (OR), 2.30; 95% confidence interval (CI), 1.39–3.79) and rs9939609 (TT vs AA: odds ratio (OR), 2.78; 95% confidence interval (CI), 1.37–5.64) were significantly associated with obesity and conferred 2-fold and 3-fold risk toward the development of obesity respectively. Logistic regression analysis determined the significant association under the recessive genetic model (OR = 2.29; 95%CI: 1.47–3.57) and (OR = 5.25; 95%CI: 2.68–10.28) respectively for rs17817449 and rs9939609 thereby confirming the major role of environmental and anthropometric factors in this population. Haplotype analysis revealed that TA haplotype conferred 4-fold risk towards obesity (p = 0.0001). The rs17817449G allele and the obesity associated covariates accounted for 55%, 49%, 42%, 34%, 31% and 22% variability in body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglyceride (TG) respectively. For rs9939609A allele contributed 98%, 82%, 54%, 59%, 71% and 84% variability in BMI, WC, WHtR, SBP, DBP, TG respectively in obese individuals. Therefore, the present study suggested that both the polymorphisms of FTO gene (rs17817449 T > G and rs9939609 T > A) are relevant markers of obesity in the north Indian Punjabi population and both plays an important role in an individual’s predisposition towards obesity.
Tastes and colours: a qualitative study of the lived experience of methylphenidate prescribed for children with a fetal alcohol spectrum disorder
Authors: Morin Clémentine , Doray Bérénice , Dumar Cécilia , Balit Jude , Bouscaren Nicolas , Spodenkiewicz Michel
Published: March 2023

Fetal Alcohol Spectrum Disorders (FASD) refer to physical, cognitive, and behavioural symptoms in an individual whose mother consumed alcohol during pregnancy. It is the leading cause of non-genetic avoidable mental disability, with an estimated worldwide prevalence of 1%. Attention Deficit Hyperactivity Disorder (ADHD) diagnostic criteria are met for 50–80% of patients with FASD. Methylphenidate (MPH) is the first-line pharmacological treatment for ADHD. This study aims to explore the lived experience of children with FASD taking MPH and their caregivers to adapt prescribing modalities by considering different ways to administer the drugs. We hope to improve the therapeutic alliance between the children and their caregivers by gaining an insiders’ view of the medication perception. Semi-structured interviews with children and their caregivers were conducted in this qualitative study. Data collection by purposive sampling continued until we reached theoretical sufficiency. Data were analysed using interpretative phenomenological analysis. We conducted 16 semi-structured interviews: 8 with the children aged 7 to 12, 5 boys and 3 girls and 8 with their caregivers. The analysis showed that inadequate palatability and capsule form experiences were the leading causes of children's non-adherence to the treatment. MPH appeared to be a valuable aid for caregivers even if they had concerns about its potential toxicity. However, it is necessary to identify caregivers' expectations concerning MPH to adapt the prescription in terms of choice of specialty and intake modalities. Regular support was required to reduce caregivers’ fears of dependence,personality transformation and long-term adverse effects. Information on palatability should be given when prescribing MPH to children with ADHD as well as its possible side effects or toxicity. It highlights the need for further studies of the experience of palatability of drugs prescribed to children. When prescribing a treatment, it is necessary to understand the child's perspectives via mediators to co-construct common representations for better therapeutical adherence.
The trachea, a missed organ in esophageal atresia complex: Evolution of a thoracoscopic approach
Authors: Elbarbary Mohamed M , Magdy Basma , Hamed Dina Hossam El Dine , Naguib Maggie L , Hussein Ayman , Kaddah Sherif , Bahaaeldin Khaled , Wishahy Ahmed MK , Elseoudi Mohamed
Published: March 2023

Purpose
We report our experience with a thoracoscopic repair of esophageal atresia, pitfalls made and how avoiding them yielded a better outcome for our patients.
Methods
Prospective cohort study was conducted to thoracoscopically repaired type-C EA patients between November 2016 and November 2022. Group A included patients, who were managed during the initial phase of our study and presented with different respiratory symptoms. Group B, that included patients who had their repair done later in the study period after refining our surgical techniques to overcome the earlier fallacies.
Results
In group A, 26 patients had successful repair, 15 patients developed respiratory-related symptoms due to esophageal causes (3/15) and tracheal causes (12/15). Tracheomalacia (11/15), tracheal diverticulum (10/15) and recurrent tracheoesophageal fistula (rTEF) (3/15) were detected in that group. In group B, which included 57 patients, significant reduction in the number of symptomatizing patients was noticed, from 58 to 30%. Seventeen patients developed symptoms, secondary to esophageal origin (12/17), rTEF (4/17) and tracheomalacia in addition to the rTEF in one patient.
Conclusions
Tracheal abnormalities with EA need more attention. Not only is bronchoscopy an informative initial step before attempting repair, but it may also reveal the possible need for primary tracheopexy.
Spatial and temporal epidemiology of FMD in Bhutan (2011-2019)
Authors: Letho Sangay , Compton Chris
Published: March 2023

Background

Foot and Mouth Disease (FMD) is an important disease in livestock in Bhutan due to its significant social and economic impacts to the farmers as well as to the government. FMD outbreaks continue to occur every year with greater frequency in some parts of the country despite the implementation of control measures. It is imperative to understand the current patterns of the disease for planning effective control programs. Therefore, this study aimed to investigate the spatial and temporal patterns of FMD in Bhutan since the most recent national survey.

Methodology

Nine year’s (2011–2019) of national FMD outbreak data was used for this study. An investigation of global spatial autocorrelation was undertaken using the K difference function statistic and local spatial clusters of FMD outbreaks using Kulldorff’s spatial scan statistic. Retrospective spatio-temporal analysis was conducted using a Bernoulli probability model with monthly aggregation of data. A non-stationary cosinor model was used to examine seasonality and trend of outbreaks.

Results

The K function statistic detected significant global spatial autocorrelation of FMD outbreaks (p < 0.01) and Kulldorff’s spatial scan statistic identified two outbreak clusters in west Bhutan- the first primary cluster (p < 0.02) with relative risk (RR) of 5.22 and radius of 19.77km in Paro and Thimphu districts and the second primary cluster (p < 0.02, RR = 8.44 radius: 8.98km) in Punakha and Wangdue Phodrang districts. The spatio-temporal scan test detected a single significant (P < 0.001) space-time cluster of 22 FMD outbreaks centred in south-west Bhutan with a radius of 60 km over an 8-month period in 2018–2019. The temporal analysis indicated that, on an average there were 0.5 (95% CI: 0.2–0.8) additional outbreaks per month in the seasonal winter peaks at 1.9 months (95% CI: 12.55–3.64) compared with the overall monthly average.

Conclusion

The western and southern regions of Bhutan have experienced the greatest overall incidence and significant spatial and spatio-temporal clusters of outbreaks of FMD during the period 2011–2019, These findings in districts in the western medium FMD risk surveillance zone threaten progress to control of FMD in Bhutan.
Tfs1, transcription elongation factor TFIIS, has an impact on chromosome segregation affected by pka1 deletion in Schizosaccharomyces pombe
Authors: Takenaka Kouhei , Nishioka Shiho , Nishida Yuki , Kawamukai Makoto , Matsuo Yasuhiro
Published: March 2023

The cAMP-dependent protein kinase (PKA) pathway in Schizosaccharomyces pombe plays an important role in microtubule organization and chromosome segregation. Typically, loss of functional Pka1 induces sensitivity to the microtubule-destabilizing drug thiabendazole (TBZ) and chromosome mis-segregation. To determine the mechanism via which Pka1 is involved in these events, we explored the relevance of transcription factors by creating a double-deletion strain of pka1 and 102 individual genes encoding transcription factors. We found that rst2∆, tfs1∆, mca1∆, and moc3∆ suppressed the TBZ-sensitive phenotype of the pka1∆ strain, among which tfs1∆ was the strongest suppressor. All single mutants (rst2∆, tfs1∆, mca1∆, and moc3∆) showed a TBZ-tolerant phenotype. Tfs1 has two transcriptional domains (TFIIS and Zn finger domains), both of which contributed to the suppression of the pka1∆-induced TBZ-sensitive phenotype. pka1∆-induced chromosome mis-segregation was rescued by tfs1∆ in the presence of TBZ. tfs1 overexpression induced the TBZ-sensitive phenotype and a high frequency of chromosome mis-segregation, suggesting that the amount of Tfs1 must be strictly controlled. However, Tfs1-expression levels did not differ between the wild-type and pka1∆ strains, and the Tfs1-GFP protein was localized to the nucleus and cytoplasm in both strains, which excludes the direct regulation of expression and localization of Tfs1 by Pka1. Growth inhibition by TBZ in pka1∆ strains was notably rescued by double deletion of rst2 and tfs1 rather than single deletion of rst2 or tfs1, indicating that Rst2 and Tfs1 contribute independently to counteract TBZ toxicity. Our findings highlight Tfs1 as a key transcription factor for proper chromosome segregation.
A closed-form solution for the three-body problem and a Sun-Earth-Moon orbit solution
Authors: Abdel-Rahman A. S.
Published: March 2023

The study of the motions of planets, satellites, and other celestial bodies is one of the important problems in basic physics and astronomy. The solution to the two-body problem enables astronomers to predict the orbits of the Moon, satellites, and spaceships around the Earth. The general analytic solution for the three-body problem stands unsolved except in some special cases, such as the Sun-Earth-Moon problem, in which the mass of the Moon is neglected. This reduces the problem to a two-body problem. In this work, the author presents a general solution to the problem in a closed form in terms of two basic particle-particle vectors. The position vector of each particle is expressed in terms of the centre of mass and the two basic particle-particle vectors. This solution is used for studying the three-body problem with gravitational interaction without imposing the non-zero-total angular-momentum condition or ignoring any masses. The Sun-Earth-Moon problem was solved in the general case and showed an expected orbital motion with a perturbation in the Earth-Sun orbit due to the revolution of the Moon. This solution is the key to future studies for n-body problem solutions.
Testi-lelki rekreáció a Rockenbauer Pál Dél-dunántúli Kéktúra útvonal mentén : Coaching az erdőben
Authors: Nagyné Farkas Rita , Biróné Ilics Katalin , Nagyváradi Katalin
Published: March 2023

Az emberek egészségi állapotával különböző társadalomtudományi megközelítésekben foglalkoznak a kutatók. Valamennyien megegyeznek abban, hogy azt több tényező együttes hatása befolyásolja. Ezt a komplexitást mutatja az egészségfogalom, valamint a rekreáció fogalma is. Írásunkban egy mentális fejlesztésre fókuszáló, de a fizikai aktvitást sem mellőző, az országban egyedülálló rekreációs tevékenységet mutatunk be. A Szerző a természet adta lehetőségeket hívja segítségül az egyének lelki megújulást célzó folyamataiba, egyúttal jól – létük megteremtésébe, fenntartásába, fejlesztésébe.
Linear electron accelerator for energy 8-50 MeV with injection from an electron source based on cluster plasma systems
Authors:   National Research Nuclear University ", Ashanin Ilya A. ,   MEPhI", Kluchevskaia Yulia D. ,   National Research Nuclear University "MEPhI", Polozov Sergey M. ,   National Research Nuclear University "MEPhI", Rashchikov Vladimir I. ,   National Research Nuclear University "MEPhI"
Published: March 2023

For many years, one of the key problems of modern accelerator physics has been an increase of the rate of the energy gain in RF linear electron accelerators. The physical limits of the accelerating field intensity for metallic accelerating structures have been practically reached; therefore, new acceleration schemes are being considered, primarily acceleration in plasma and wakefield acceleration. The second aim is the generation of ultrashort (100 fs and less) electron bunches, for which RF photoguns are traditionally used. In this case, for RF photoguns, a serious problem that limits the intensity of electrons in a bunch is the influence of the own space charge during emission and acceleration in the near-cathode region, where the beam is weakly relativistic and the influence of the space charge on its dynamics plays the determinative role. The possibility of using a plasma cathode source as an injector for RF accelerator will considered. In the future, this may make it possible to bypass the limitations inherent in RF photoguns (sufficient influence of the space charge on the beam dynamics in the near-cathode region) and acceleration in the laser-plasma channel (low electron capture coefficient in the acceleration mode, wide energy spectrum - 10% or more at energies of tens and hundreds of megaelectrons). It is proposed to develop a combined accelerator in which a bunch generated in a laser-plasma channel is injected into a traditional metal structure. It is supposed that could be possible to generate a short (from 0.1 to 1.0 ps) electron bunches with an energy of several hundred kiloelectrons, which will make it possible to consider such source as an alternative to the photocathode. Next, the beam must be captured in the acceleration mode in a normally conducting section and accelerated to an energy of 50 MeV with the possibility of energy tuning. The features of such accelerator, the features of the electron bunch capturing in the acceleration mode, and the possible values of the energy spectrum in such a system will considered.
Perspectives of Great Britain’s defense policy in 2020–2030s
Authors:   Institute of the USA and Canada of the Russian Academy of Sciences, Shkrobtak Igor
Published: March 2023

This study is devoted to the study of the main directions of the development of British defense and security policy. The article analyzes the main directions of the strategy of this sphere of activity of the United Kingdom, examines the situation of the British military-industrial complex and the main challenges facing the national defense and security of London. The paper explores the main directions of defense and security policy, the vision of challenges by the British political and military leadership. The turn of the United Kingdom’s priorities in defense and security from “hybrid threats” to the possibility of confrontation with the regular forces of major military powers and its causes are revealed. One of the most important observations in the article is the role of the withdrawal of Allied troops from Afghanistan and its consequences in the British defense strategy. The importance of the Ukrainian conflict since February 24, 2022 and the involvement of British military and political resources in it is emphasized. The paper also examines the possible consequences of this conflict for British defense and security. The main conclusion of the work is the thesis about the collapse of the concept of “Global Britain” due to the lack of adequate resources to control a number of regions (first of all, we are talking about the Middle East, the Black Sea basin and Central Asia) and the decline in the level of competence of the top political leadership of the United Kingdom. The crisis in the British military-industrial complex and its dependence on foreign technologies and products is stated. In addition, the study predicts a possible fundamental reformatting of British foreign policy due to the challenges facing the defense and security of London.
Specifics of perception of conscience and life values of two generations (on the example of Russia and Georgia)
Authors:   Herzen State Pedagogical University of Russia, Korjova Elena , Kaznina Eka ,   Herzen State Pedagogical University of Russia
Published: March 2023

The article examines the perception of conscience and life values of two generations of Georgians and Russians, which allows one to look at the events taking place in the current reality, not only from a theoretical point of view. In addition to the identified ethno-cultural and intergenerational differences, the paper presents the results of an empirical identification of the invariant of perception of conscience in two cultures. With the help of comparative and correlation analysis of empirical data, it was shown that conscience is actualized mainly in the area of normative or realizable significant life values. The interrelationships between the indicators of a person’s life values and perception of conscience established in the study can be interpreted as zones in which the work of conscience is carried out, also it can be supposed what the features of a conscientious act will be. The spiritual and moral sphere is inseparable from personal functioning, which is realized by each person in the process of life in order to fulfill his predestination. The study used both domestic and Western methods, which complicated the interpretation of the results and required additional analysis. We are talking about the results of processing the MJT method by G. Lind. In addition to this technique, the study used the Questionnaire of the Properties and States of Conscience by V. Kh. Manerov and “The Study of Value Orientations” by S. Schwartz.
BNCC, ensino médio e educação física
Authors: Gilioli Eduardo Borba , Galuch Maria Terezinha Bellanda , Sanches Eduardo Oliveira
Published: March 2023

Esta pesquisa, de caráter bibliográfico, apoia-se na Teoria Crítica da Sociedade, para analisar a proposta formativa que baliza a Base Nacional Comum Curricular para a Educação Física no Ensino Médio, tensionando a reforma nesse nível de ensino. A proposta da Educação Física no Ensino Médio ao pautar-se em habilidades e competências, secundarizando os conteúdos específicos da área, revela um modelo formativo que atua nos limites da adaptação dos sujeitos ao trabalho precarizado, sob o fetiche tecnológico da produção flexível, em vez de primar pela educação que conduz ao desenvolvimento de indivíduos autônomos e autorreflexivos, embora o documento enfatize uma suposta formação crítica.
From Taboo to Wellness: The Facts behind Menopause
Authors: Hollands Peter
Published: March 2023

Menopause is a significant milestone in a woman's life, marking the end of fertility and the start of a new phase. However, it can also bring many physical and emotional symptoms, such as hot flashes, mood changes, and a higher risk of osteoporosis and heart disease. Because of these issues, dealing with menopause can be a challenge.

From Taboo to Wellness: The Facts behind Menopause is an informative guide to menopause. It provides clarity and accessibility for anyone interested in understanding the topic, and wants to deconstruct any myths that surround it with facts. From symptoms to treatments, this book covers everything you need to know about menopause in an engaging and easy-to-understand way.

Written with the general reader in mind, this book explores the science behind menopause, as well as the male andropause and how it differs from the female experience. With insights into Hormone Replacement Therapy (HRT) and future treatments using stem cells, it gives a comprehensive understanding of the options for managing menopause. But that's not all - the book also delves into the fascinating world of menopause in the animal kingdom, offering a unique perspective on how different species experience hormonal changes caused by this life-changing event.
From Reluctance to Acceptation: Participation of Poor-People in Policy Implementation Using Discursive Institutionalism
Authors:   Ilmu Politik Universitas Brawijaya, Edi Kuswandoro Wawan
Published: March 2023

The poor-people reluctance in participation in government’s policy implementation was caused by by the distance of government policy discourse and poor-people discourse. This article investigates policy implementation of sanitation program in Probolinggo City, East Java using Discursive Institutionalism perspective and Fairclough’s Critical Discourse Analysis method to discover hidden meanings of the multi-actor’s discourse. The research found, first, the reluctance of poor-people participation in policy implementation was caused by negative discourse on sanitation interpellated the poor-people. Second, acceptation for the program implemented was achieved by narrowing the gap of discourse through penetration of alternative discourse constructed under policy design. Third, policy implementor’s discourse was exercised by breaking personal discourse of the people. Forth, discursive strategy changed personal discourse of society which then shifts reluctance to acceptance for government programs. Fifth, policy design for activating urban poor-people’s participation as social engineering based on discourse and discursive strategy.
Role of religious and language factors in the integration policy in Iran (XX – early XXI century)
Authors:   Institute of Oriental Studies, Russian Academy of Sciences, Marina Samuilovna Kameneva ,   Peoples’ Friendship University of Russia (RUDN University)
Published: March 2023

The article considers the role of religious and language factors in the integration policy in Iran both before the Islamic Revolution of 1979 and in the Islamic Republic of Iran. The analysis of the situation in the former period when the Pahlavi dynasty was in power in the country shows that at that time in the history of Iran there dominated the language factor, that is, the Persian lan-guage, with full respect for Islam, the dominant religion in the country. At the same time, after the Islamic Revolution the situation changes, and the religious factor comes to the fore, which occupies the dominant position to this day. As for the language factor, it is the Persian language rather than Arabic that plays a very important, but no longer leading role in the policy of national integration in modern Iranian society. The shift of the emphasis from Arabic to Persian appears to be quite ap-propriate and reasonable on the part of the Iranian authorities, since the Persian language symboliz-es the ancient Iranian culture; it is regarded as the second most important language of the Islamic world and is an important factor in the Sunni-Shia dialogue.
The Hudud Acts: Classification, Esse, Disputed Issues
Authors:   independent researcher, Dzhamali Tofikovich Kuliev
Published: March 2023

This study is a follow-up of the author’s earlier article [10, pp. 89–101]. The author aims at examining the hudud sinful acts in detail. For the first time in Russian Islamic studies, the author proposes that the group of the hudud acts should be supplemented with usury (riba) and sodomy since both of them have a high degree of public danger for the Muslim community and provide for punishment in the Sunnah by Prophet Muhammad. The author also raises the question of excluding apostasy (irtidad) from the list of the hudud acts since Islam presupposes freedom of worship. Ac-cording to the author, the hadiths indicating the existence of punishment for this act should be in-terpreted in a broader way, with all circumstances taken into consideration.
Textual Analysis of “Sharh al-Mafrud” by Muhammad Tahir аl-Karahi
Authors:   Educational religious organization of higher education “Sheikh Muhammad-Arif Dagestan Islamic University”, Magomed Saaduevich Akhmedkhabibov
Published: March 2023

The study is devoted to the textual analysis of the essay on Muslim law “Sharkh al-Mafrud”, written by Dagestani theologian Muhammadtahir al-Karahi. The essay is compiled in the traditional genre of legal Muslim works. At the same time, it has a number of peculiarities that gen-erally reflect the characteristic features of Muslim law functioning in the North Caucasus in the 19th century. The study reveals the motives for composing this work, its structure and other specific fea-tures. Particular attention is paid to the topics that worried the minds of Muslims of that period and caused heated discussions in Dagestani intellectual and spiritual elite. Al-Karahi did not stay away from those discussions and his position on certain legal issues is reflected in the book.
INVESTIGATION OF THE EFFECT OF THE INTRODUCTION OF «GREEN» ROOFS USING SIMULATION CALCULATIONS ON THE EXAMPLE OF THE CITY OF TULA
Authors: LAPIN ALEXEY , SYSOEVA ELENA
Published: March 2023

Environmental issues in large, including industrial cities of Russia, are acute, since the execution of production processes and simultaneous control over the well-being of the environment is a complex multifactorial aspect that requires careful study and elaboration. In addition, there is a sharp shortage of public green spaces in many territories, which are regulated by legislation and are designed to increase the environmental comfort of citizens. In densely populated cities, the issue of providing residents with green spaces is accompanied by a lack of free space, «green roofs» are able to solve this problem without taking up additional space in the city, compactly placed on the roofs of existing buildings, while increasing the commercial attractiveness of objects and preserving the enclosing multilayer coating system. The article considers a brief historical background of the development of the technology of «green» roofs in the world and in Russia, provides examples of modern buildings and structures actively using this technology, explains the general structure of the modern «green» roof in the context of the current regulatory documentation. The collection and analysis of data on the example of the Tula region concerning demographic, social and environmental indicators for correlation calculation was carried out. Graphs and polynomial trend lines of various environmental factors are constructed, determination coefficients and functions of trend lines are determined. A correlation matrix is compiled, conclusions are drawn about the possible improvement of the ecology of the urban architectural environment. A regression analysis was performed with statistical results entered into a tabular form. Based on the function obtained as a result of regression analysis, simulation modeling of the population was carried out, taking into account the increase in the area of green spaces of general use
The Adoption of a COVID-19 Contact-Tracing App: Cluster Analysis
Authors: Hengst Tessi M , Lechner Lilian , van der Laan Laura Nynke , Hommersom Arjen , Dohmen Daan , Hooft Lotty , Metting Esther , Ebbers Wolfgang , Bolman Catherine A W
Published: March 2023

Background

During the COVID-19 pandemic, there was limited adoption of contact-tracing apps (CTAs). Adoption was particularly low among vulnerable people (eg, people with a low socioeconomic position or of older age), while this part of the population tends to have lesser access to information and communication technology and is more vulnerable to the COVID-19 virus.

Objective

This study aims to understand the cause of this lagged adoption of CTAs in order to facilitate adoption and find indications to make public health apps more accessible and reduce health disparities.

Methods

Because several psychosocial variables were found to be predictive of CTA adoption, data from the Dutch CTA CoronaMelder (CM) were analyzed using cluster analysis. We examined whether subgroups could be formed based on 6 psychosocial perceptions (ie, trust in the government, beliefs about personal data, social norms, perceived personal and societal benefits, risk perceptions, and self-efficacy) of (non)users concerning CM in order to examine how these clusters differ from each other and what factors are predictive of the intention to use a CTA and the adoption of a CTA. The intention to use and the adoption of CM were examined based on longitudinal data consisting of 2 time frames in October/November 2020 (N=1900) and December 2020 (N=1594). The clusters were described by demographics, intention, and adoption accordingly. Moreover, we examined whether the clusters and the variables that were found to influence the adoption of CTAs, such as health literacy, were predictive of the intention to use and the adoption of the CM app.

Results

The final 5-cluster solution based on the data of wave 1 contained significantly different clusters. In wave 1, respondents in the clusters with positive perceptions (ie, beneficial psychosocial variables for adoption of a CTA) about the CM app were older (P<.001), had a higher education level (P<.001), and had higher intention (P<.001) and adoption (P<.001) rates than those in the clusters with negative perceptions. In wave 2, the intention to use and adoption were predicted by the clusters. The intention to use CM in wave 2 was also predicted using the adoption measured in wave 1 (P<.001, β=–2.904). Adoption in wave 2 was predicted by age (P=.022, exp(B)=1.171), the intention to use in wave 1 (P<.001, exp(B)=1.770), and adoption in wave 1 (P<.001, exp(B)=0.043).

Conclusions

The 5 clusters, as well as age and previous behavior, were predictive of the intention to use and the adoption of the CM app. Through the distinguishable clusters, insight was gained into the profiles of CM (non)intenders and (non)adopters.

Trial Registration

OSF Registries osf.io/cq742; https://osf.io/cq742
Information Circulation Among Spanish-Speaking and Caribbean Communities Related to COVID-19: Social Media–Based Multidimensional Analysis
Authors: Vargas Meza Xanat , Park Han Woo
Published: March 2023

Background

Scientiﬁc studies from North America and Europe tend to predominate the internet and beneﬁt English-speaking users. Meanwhile, the COVID-19 death rate was high at the onset of the pandemic in Spanish-speaking countries, and information about nearby Caribbean countries was rarely highlighted. Given the rise in social media use in these regions, the web-based dissemination of scientific information related to COVID-19 must be thoroughly examined.

Objective

This study aimed to provide a multidimensional analysis of peer-reviewed information circulation related to COVID-19 in Spanish-speaking and Caribbean regions.

Methods

COVID-19–related, peer-reviewed resources shared by web-based accounts located in Spanish-speaking and Caribbean regions were identified through the Altmetric website, and their information was collected. A multidimensional model was used to examine these resources, considering time, individuality, place, activity, and relations. Time was operationalized as the 6 dates of data collection, individuality as the knowledge area and accessibility level, place as the publication venue and affiliation countries, activity as the Altmetric score and number of mentions in the selected regions, and relations as coauthorship between countries and types of social media users who disseminated COVID-19–related information.

Results

The highest information circulation peaks in Spanish-speaking countries were from April 2020 to August 2020 and from December 2020 to April 2021, whereas the highest peaks in Caribbean regions were from December 2019 to April 2020. Regarding Spanish-speaking regions, at the onset of the pandemic, scientific expertise was concentrated on a few peer-reviewed sources written in English. The top scientiﬁc journals mentioned were from English-speaking, westernized regions, whereas the top scientiﬁc authorships were from China. The most mentioned scientific resources were about breakthrough findings in the medical and health sciences area, written in highly technical language. The top relationships were self-loops in China, whereas international collaborations were between China and the United States. Argentina had high closeness and betweenness, and Spain had high closeness. On the basis of social media data, a combination of media outlets; educational institutions; and expert associations, particularly from Panama, influenced the diffusion of peer-reviewed information.

Conclusions

We determined the diffusion patterns of peer-reviewed resources in Spanish-speaking countries and Caribbean territories. This study aimed to advance the management and analysis of web-based public data from non-white people to improve public health communication in their regions.
The Use of Digital Health Services Among Patients and Citizens Living at Home: Scoping Review (Preprint)
Authors: Rosenlund Milla , Kinnunen Ulla-Mari , Saranto Kaija
Published: March 2023

BACKGROUND

The development of digital health services reflects not only the technical development of services but also a change in attitude and the way of thinking. It has become a cornerstone for engaging and activating patients and citizens in health management while living at home. Digital health services are also aimed at enhancing the efficiency and quality of services, while simultaneously providing services more cost-effectively. In 2020, the COVID-19 pandemic accelerated worldwide the development and use of digital services in response to requirements for social distancing and other regulations.

OBJECTIVE

The aim of this review is to identify and summarize how digital health services are being used among patients and citizens while living at home.

METHODS

The Joanna Briggs Institute (JBI) methodology for scoping reviews was used as guidance. A search conducted in 3 databases (CINAHL, PubMed, Scopus) resulted in 419 papers. The reporting was conducted by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping review (PRISMA-ScR), and the analysis of the included papers was performed using a framework consisting of 5 clusters describing the use of digital health services. After screening and excluding papers that did not match the inclusion criteria, 88 (21%) papers from 2010 to 2022 were included in the final analysis.

RESULTS

Results indicated that digital health services are used in different situations and among different kinds of populations. In most studies, digital health services were used in the form of video visits or consultations. The telephone was also used regularly for consultations. Other services, such as remote monitoring and transmitting of recorded information and the use the of internet or portals for searching information, were observed as well. Alerts, emergency systems, and reminders were observed to offer possibilities of use, for example, among older people. The digital health services also showed to have potential for use in patient education.

CONCLUSIONS

The development of digital services reflects a shift toward the provision of care regardless of time and place. It also reflects a shift toward emphasis on patient-centered care, meaning activating and engaging patients in their own care as they use digital services for various health-related purposes. Despite the development of digital services, many challenges (eg, adequate infrastructure) still prevail worldwide.
From the Cochrane Library: Interventions for Ulceration and Other Skin Changes Caused by Nerve Damage in Leprosy (Preprint)
Authors: Anderson Lachlan , Adelman Madeline , Reinar Liv Merete , Dellavalle Robert P
Published: March 2023

UNSTRUCTURED
Personalized Coaching via Texting for Behavior Change to Understand a Healthy Lifestyle Intervention in a Naturalistic Setting: Mixed Methods Study (Preprint)
Authors: Bäccman Charlotte , Bergkvist Linda , Wästlund Erik
Published: March 2023

BACKGROUND

Digital health interventions, such as personalized SMS coaching, are considered affordable and scalable methods to support healthy lifestyle changes. SMS, or texting, is a readily available service to most people in Sweden, and personalized SMS coaching has shown great promise in supporting behavior changes.

OBJECTIVE

This study aims to explore the effectiveness of highly personalized SMS coaching for behavior change according to the Capability, Opportunity, Motivation–Behavior (COM-B) model on a sample of physically inactive adults in a nonprofit fitness organization in Sweden.

METHODS

The study used a mixed methods design in which clients acted as their own controls. The participants were clients (n=28) and fitness consultants (n=12). Three types of data were collected: (1) quantitative data at baseline and after the SMS intervention and the waitlist from the clients, (2) qualitative data from semistructured interviews with the fitness consultants, and (3) pseudonymized texting conversations between the fitness consultants and clients.

RESULTS

Overall, the results showed that personalized SMS coaching was effective in supporting the clients’ behavior changes. The quantitative analysis showed how the clients’ capabilities (Cohen d=0.50), opportunities (Cohen d=0.43), and relationship with the fitness consultants (Cohen d=0.51) improved during the SMS intervention in comparison with baseline. Furthermore, the qualitative analysis revealed how personalized texts added value to existing work methods (eg, increasing continuity and flexibility) and how the relationship between the clients and fitness consultants changed during the intervention, which helped motivate the clients.

CONCLUSIONS

Personalized SMS coaching is an effective method for supporting healthy behavior changes. The human connection that emerged in this study needs to be further explored to fully understand the effectiveness of a digital health intervention.
Assessment and Documentation of Social Determinants of Health Among Health Care Providers: Qualitative Study (Preprint)
Authors: Yelton Brooks , Rumthao Jancham Rachel , Sakhuja Mayank , Macauda Mark M , Donelle Lorie , Arent Michelle A , Yang Xueying , Li Xiaoming , Noblet Samuel , Friedman Daniela B
Published: March 2023

BACKGROUND

Research clearly demonstrates social determinants of health (SDOH) impact health outcomes. Provider consideration of patient SDOH in prevention and treatment planning is critical for improved health care quality and health equity. Despite awareness of the connections between SDOH and improved population health, research demonstrates few providers document patient SDOH.

OBJECTIVE

This qualitative study aimed to better understand the barriers and facilitators of SDOH assessment, documentation, and referral in different health care settings and roles.

METHODS

Individual semistructured interviews were conducted with practicing health care providers in South Carolina between August 25, 2022, and September 2, 2022. Participants were recruited via community partners’ web-based newsletters or listservs using a purposive sampling design. An interview guide with 19 questions was used to explore the following research question: How do SDOH impact patient health and what are the facilitators and barriers experienced by multidisciplinary health care providers assessing and documenting patient SDOH?

RESULTS

Participants (N=5) included a neonatal intensive care unit registered nurse, a nurse practitioner, a certified nurse midwife, a family and preventive medicine physician, and a counselor (licensed clinical social worker) with careers spanning 12 to 32 years. Participant responses are presented according to the following 5 themes: participants’ understanding of SDOH for the patient population, assessment and documentation practices, referrals to other providers and community-based resources, barriers and facilitators of SDOH assessment and documentation, and SDOH assessment and documentation training preferences. Overall, participants were aware of the importance of including patient SDOH in assessment and intervention but noted a variety of institutional and interpersonal barriers to assessment and documentation, including time constraints, perceptions of stigma around discussion of SDOH, and limited referral protocols.

CONCLUSIONS

Incentivizing inclusion of patient SDOH in health care must be facilitated from the top down, so assessment and documentation can be universally implemented in a pragmatic way that works for providers in a variety of roles and settings for the betterment of health care quality, health equity, and improved population health outcomes. Partnering with community organizations can serve to augment health care organizations’ resource and referral availability for addressing patients’ social needs.
Revaluation fantasy
Authors: Muniesa Fabian
Published: March 2023

“NESARA/GESARA” pops up easily when one searches for the financial element in conspiratorial, millennialist fantasies today. The acronym, NESARA, stood initially for National Economic Stabilization and Recovery Act: a rather fringe policy proposal ideated in the 1990s by Harvey F. Barnard, a consultant and founder of a NESARA Institute established in Greenwell Springs, Louisiana. The initiative, which took the form of a proposed bill but was never introduced before the US Congress, consisted in a systematic monetary and fiscal reform aiming at “general prosperity” (against the “contrived scheme” put in place by “power brokers in Washington, DC”) and included things such as the restoration of gold as constitutional currency, the end of the Federal Reserve System, the elimination of national debt, the abolition of compound interest on loans, and of income tax. The 2000s saw the acronym evolve, now standing for National Economic Security and Reformation Act and referring to a rather esoteric version of the plan, soon acquiring a planetary dimension, in the form of a Global Economic Security and Reformation Act, GESARA. Shaini Goodwin - a spirituality and investment consultant known as the “Dove of Oneness” in New Age internet circles - spearheaded this new conspiratorial interpretation. The “global currency reset” and the general “revaluation” the reform called for were considered to be in fact underway, although in a secret, occulted fashion, with an adverse league of political and financial elites conspiring against the changes. NESARA/GESARA also started to carry a distinctive spiritual, prophetic element, with the restoration of the fair, original, real value of persons and things being connected to the equilibrium of energies - at once planetary, cosmic, mystical, psychic, extra-terrestrial, interdimensional, divine, and economic.
Stability of solutions to fractional differential equations with time-delays
Authors: Fenizri F. , Guezane-Lakoud A. , Khaldi R.
Published: March 2023

This paper deals with a fractional boundary value problem involving variable delays. Sufficient conditions for the existence of a unique solution are investigated. Moreover the stability of the unique solution is discussed. A numerical example that emphasizes the importance of the results obtained in this article is also included.
The structure of power digraph connected with the congruence a¹¹ ≡ b(mod n)
Authors: Goswami Pinkimani , Thakur Sanjay Kumar , Ray Gautam Chandra
Published: March 2023

We assign to each positive integer n a digraph Γ(n, 11) whose set of vertices is Zn = {0, 1, 2, ..., n − 1} and there exists exactly one directed edge from a to b if and only if a11 ≡ b(mod n), where a, b ∈ Zn. Let Γ1(n, 11) be the subdigraph induced by the vertices which are coprime to n. We discuss when the subdigraph Γ1(n, 11) is regular or semi-regular. A formula for the number of fixed points of Γ(n, 11) is established. A necessary and sufficient condition for the symmetry of the digraph Γ(n, 11) is proved. Moreover, using Carmichael ́s lambda function, the number of components and conditions for the existence of cycles in the digraph Γ(n, 11) is presented.
Subspace spanning graph topological spaces of graphs
Authors: Aniyan Achu , Naduvath Sudev
Published: March 2023

A collection of spanning subgraphs TS, of a graph G is said to be a spanning graph topology if it satisfies the three axioms: Nn, K0 ∈ TS where, n = |V (G)|, the collection is closed under any union and finite intersection. Let (X, T) be a topological space in point set topology and Y ⊆ X then, TY = {U ∩ Y : U ∈ T} is a topological space called a subspace topology or relative topology defined by T on Y . In this paper we discusses the subspace spanning graph topology defined by the graph topology TS on a spanning subgraph H of G.
Evaluating the Effectiveness of Energy-Efficient Design Strategies in Achieving Net Zero Energy Building through Reduced Energy Consumption
Authors: Dwivedi Ekta , Kashyap Raman , Kumar Ravi Ranjan
Published: March 2023

Abstract: Net zero energy buildings (NZEBs) have emerged as a sustainable and energy-efficient solution to the challenges of climate change and rising energy costs. These buildings are designed to generate as much energy as they consume, resulting in zero net energy consumption. The paper explores the evolution of NZEBs and the latest emerging technologies that are enabling their development, including smart building automation systems, energy-efficient lighting and HVAC systems, vacuum insulation panels, Building Integrated Photovoltaic (BIPV) systems, and advanced sensors. The effectiveness of these strategies is analyzed using Autodesk insights and Revit software. The paper also discusses the comparison of Energy Use Intensity (EUI) before and after implementing energy-efficient and renewable energy techniques, which is crucial in determining their effectiveness. The proposed building achieved a significant 57.3% reduction in energy consumption after implementing various NZEB design strategies, resulting in a mean EUI value of 99.8 kWh/sq. m/year. The analysis was conducted using Autodesk Insights and Revit software, utilizing the Building Information Modeling (BIM) approach for building design. This paper concludeswitha discussion on the future of NZEBs and how they are an important step towards achieving sustainable and efficient energy use in the building sector,resultingincostsavings andreducedcarbon emissions
Smart Health Consulting Online System Using Blockchain
Authors: Sainath G , Tanishq K , Sujith K , Mageswari Dr. R Uma
Published: March 2023

Abstract: The current healthcare industry col-lects huge amounts of healthcare data which, unfortunately, are not “mined” to discover hid-den information for effective decision making. BlockChain has been a current trend for at-taining diagnostic results because it keeps the data secure and immutable. BlockChain further extend the support for the process of extracting hidden information from massive dataset, cate-gorizing valid and unique patterns in data. By means of this fruitful insights Blockchain is used in healthcare sector for better decision making. Researchers all over the world are working in either multi agents or in ontologies for developing system in health care domain with help of blockchain. It might have happened so many times that you or someone need doctor help but they are not available due to some reasons. The work proposed here suggests a health management system which supports end user to effectively use online consultation and uses blockchain for storing the patients insights and doctors information. Through this intelligent healthcare system the patient gets guidence from the doctor related their health issues.