bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Assessment of Cytokine Profiles and Haematological Parameters in Patients with Systemic Lupus Erythematosus: A Cross-Sectional Study from Saudi Arabia
Authors: Aldakheel Fahad M. , Alshanqiti Muwaffaq A. , Alduraywish Shatha A. , Alshammary Amal F. , Dabwan Khaled H. , Syed Rabbani
Published: December 2023

Background: Systemic lupus erythematosus (SLE)-related hematological disorders have different pathogenic mechanisms involving immune dysregulation as well as microangiopathy. The current study aimed to assess the relationship between pro- and anti-inflammatory cytokines and SLE-related hematological abnormalities for Saudi Patients. Methods: The current cross-sectional study including 140 participants was performed at the Prince Mohammad bin Abdulaziz Hospital (PMAH), Riyadh, Saudi Arabia. Two blood samples were collected from each of the study participants for evaluation of the haematological indices including complete blood count (CBC), erythrocyte sedimentation rate (ESR), and cytokine profile (i.e., tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10)). Statistical analyses were performed using the Statistical Package of Social Sciences (SPSS) software, v25. Results: Haematological abnormalities were documented in 63% of SLE patients, and anaemia was the highest at 52%. Haemoglobin levels were found to be significantly lower among SLE patients compared to the controls (p < 0.001). In the cytokine profiles, the levels of TNF-α (p < 0.001), IL-6 (p < 0.001), and IL-10 (p = 0.009) were significantly higher among SLE patients compared to the controls. A positive correlation was also identified between TNF-α, platelet count, red cell distribution width (RDW), and ESR. Conclusions: Haematological abnormalities were found to be the most common among SLE patients. Further, the correlation between cytokine profile and haematological indices indicates the influence of cytokines in the development of haematological abnormalities. Understanding hematological abnormalities and cytokines’ role in the pathogenesis of these abnormalities may aid in the early diagnosis and development of more specific SLE disease therapies.
Bioinformatic Analysis and Computer-Aided Study to Investigate the Potential Application of a Bioflavonoid Compound Bilobetin in Liver Cancer Treatment
Authors: Zhang Chunye , Sui Yuxiang , Liu Shuai , Yang Ming
Published: December 2023

Background: Hepatocellular carcinoma (HCC/LIHC) is the most common type of primary liver cancer, which is a leading cause of cancer death worldwide. Patients with HCC have a short survival time after diagnosis. Unfortunately, there are no effective treatments for advanced or aggressive HCC. Thus, the rapid development of new therapeutic drugs or treatment methods for HCC is urgently needed. Methods: Bioinformatic tools and computer-aided predictions advance the processes of drug development. In this study, we incorporated bioinformatic analyses and computer-aided drug development processes to investigate the potential application of bilobetin, a bioactive compound of bioflavonoid, as a therapeutic agent for HCC treatment. Results: Our results revealed that 4 out of 20 predicted hub target genes of bilobetin displayed functional importance in cancer-related signaling pathways in different cancers, including HCC. Importantly, the mRNA expression levels of these four key hub genes (VEGFA, SRC, MMP9, and CDK1) were significantly different between normal and HCC tumor samples. Their expression levels were significantly associated with the clinical survival outcomes of HCC patients, as well as the immune cell infiltration levels in the HCC tumor microenvironment. In addition, these four genes showed significant co-expression correlated with immune checkpoint genes, including CD274, PDCD1, CTLA4, and CD47. Furthermore, we used computer-aided approaches to investigate the binding affinity and potential binding mechanisms between bilobetin and target proteins encoded by four key hub genes. Conclusions: In conclusion, our study shed light on the potential application of the bioactive bioflavonoid molecule bilobetin in LIHC treatment by regulating four key hub genes.
Notice of Withdrawal
Authors: Editorial Office FBL
Published: December 2023

Fang Wu, Wenzhao Cheng, Feiyuan Zhao, Mingqing Tang, Yong Diao, Ruian Xu. Association of N6-methyladenosine with viruses and virally induced diseases. Front. Biosci. (Landmark Ed) 2020, 25(6), 1184–1201. https://doi.org/10.2741/4852 The above article, published online on 1 March 2020 in Front. Biosci. (Landmark Ed), has been withdrawn by agreement between the Editor-in-Chief Dr. Graham Pawelec and IMR Press. The withdrawal due to the authors not completing a copyright license agreement form.
Menyingkap Kelayakan Rencana Bisnis Atas Pemanfaatan Aset Tetap Berupa Tanah Milik Pemerintah Pusat
Authors: Nurbiyanto Nurbiyanto , Rahmanto Dwi
Published: December 2023

State-owned Assets (BMN) is an asset owned by the state that must be managed optimally. Optimal BMN management can be seen from a financial and non-financial perspective. From a financial perspective, BMN optimization provides financial input in the form of Non-Tax State Revenue (PNBP), while for non-financial optimization, BMN is used optimally by statutory provisions. This study attempts to outline the steps and calculations to determine the financial feasibility of managing BMN. BMN management is carried out in the form of utilization through utilization cooperation with potential investors. The research object is BMN in the form of empty land belonging to the Ministry of Education, Culture, Research, and Technology. A quantitative approach is used to analyze the feasibility of BMN management. Data uses primary data, secondary data, and other documents related to business plans. Data collection was carried out using field observations, interviews with potential investors, and studies via the Internet. Apart from that, the article is also based on literature studies to explore the BMN management process in the form of cooperation in utilizing BMN. The analysis concludes that BMN's business feasibility plan from the business project side is feasible, from the investor's financial side it is also feasible, while from the government side, it gets adequate capitalization.
LESSON LEARNED IMPLEMENTASI KAWASAN EKONOMI KHUSUS INDONESIA
Authors: Purwana Aditya Subur , Adi Nurcahyo Marsanto , Tri Kisworini Juli
Published: December 2023

KEK merupakan kawasan dengan batas tertentu yang mendapatkan fasilitas dengan tujuan menciptakan pertumbuhan ekonomi, pemerataan pembangunan, dan peningkatan daya saing bangsa. Namun kinerja KEK tahun 2021 hanya 28.57% yang Optimal. Penelitian ini bertujuan menganalisis implementasi KEK sehingga dapat memberikan gambaran atas ekosistem dalam KEK yang diharapkan memberikan dampak pada kinerja KEK. Menggunakan mixed methods, yaitu deskripsi kuantitatif dan kualitatif interpretatif. Data sekunder bersumber dari Badan Usaha, Pelaku Usaha dan DJBC sampai dengan Tahun 2021 sedangkan Data primer tahun 2022 melalui kuesioner, wawancara, serta observasi langsung. Sample penelitian berdasarkan jenis dan kinerja KEK. Hasil penelitian yaitu KEK menarik Badan Usaha untuk mengusulkan membangun KEK, menarik investasi PMA dan PMDN (Swasta dan Pemerintah). Jarak KEK terhadap ibukota Provinsi/ Pelabuhan/Bandar Udara Internasional berkorelasi terhadap kinerja KEK. Namun hal ini dapat dimitigasi dengan adanya infrastruktur transportasi serta kelancaran arus barang dan/atau orang di Pelabuhan ataupun Bandara. Setiap KEK memiliki keunggulan produk masing-masing. Hambatan dalam KEK, yaitu Dewan Kawasan & Administrator belum optimal, sarana dan prasarana. Pembangunan KEK memberikan dampak positif terhadap jumlah pelaku usaha, jumlah investasi, daya tarik investasi (daya saing investasi), jumlah tenaga kerja dan pertumbuhan ekonomi. Fasilitas dalam KEK sudah dimanfaatkan namun masih banyak fasilitas KEK yang belum didapatkan/dipergunakan oleh KEK.
Control interno y modelo COSO en la gestión administrativa y financiera empresarial
Authors: Catagua Briones Miguel Leonardo , Pinargote Macías María Fernanda , Mendoza Vinces Marcelo Eduardo
Published: December 2023

El propósito del artículo es evaluar el valor del control interno en la gestión administrativa y financiera en las empresas mediante el uso del modelo COSO. Se utilizó una metodología cuantitativa consistente en mapas de colores para la evaluación de riesgos, apoyado en la revisión de la literatura y la observación directa para obtener los datos necesarios de la empresa Blaufish Cía Ltda. Los resultados han determinado que el control interno se utiliza de manera empírica a través de procesos no estructurados. Se concluye que la ausencia de procesos de control interno es la causa de la mayoría de las debilidades encontradas, por lo que se recomienda el uso del modelo COSO, que puede utilizarse como herramienta para prevenir eventos negativos antes de su posible ocurrencia.
La mediación y su influencia en el clima escolar post COVID-19
Authors: Delgado Togra Danny Santiago , González-Velásquez Aurora Margarita , Arteaga Ponce Yessica Vanesa , Herrera Herrera Laura de los Ángeles
Published: December 2023

Esta investigación tuvo como propósito determinar la relación e influencia de la mediación en el clima escolar en una institución educativa de Guayaquil, mediante un estudio descriptivo – correlacional. Se aplicaron dos cuestionarios: el primero orientado a la valoración del clima escolar (α = 0.952, Ω = 0.950) y el segundo sobre el uso de la mediación (α = 0.868, Ω = 0.863). El 79.1% de los docentes señalaron que la mediación tiene una alta incidencia en el clima escolar. Los resultados inferenciales demostraron que existe una correlación positiva, fuerte, y   estadísticamente significativa entre la mediación y el clima escolar.
La Delincuencia Organizada Internacional y su Impacto en la Frontera Ecuador-Perú
Authors: Pino Icaza Edith del Rocío
Published: December 2023

La desaceleración de la economía mundial, la contracción del turismo y el marcado endurecimiento de las condiciones sociales por la migración irregular, en nuestros países vecinos ha generado un importante impacto en su desarrollo. Antes de la declaratoria de emergencia en Perú y de Excepción en Ecuador, la frontera común ya adolecía de una serie de problemas de tipo social, que se exacerbaron con la implementación de medidas de restricción sanitaria, que fueron el cierre de fronteras, restricciones de comercialización, entre otros. Este artículo pretende explorar la delincuencia organizada internacional y su impacto en la frontera Ecuador-Perú, y con ello analizar el efecto en el flujo migratorio irregular en el número de trata y tráfico de personas, estimar la afectación en el intercambio comercial y determinar si la presencia de grupos que operan al margen de la ley, afecta las relaciones vecinales y con estos elementos proponer un modelo de interoperabilidad binacional policial.
The “Nature of Theatre”: Herder’s Pursuit of a Human Theatre
Authors: Girardin Catherine
Published: December 2023

Johann Gottfried Herder is primarily known for his writings on the philosophy of history, linguistics, and theology; his ideas about theatre have been largely overlooked. His interest in the history of various human cultures and his significant influence on the birth of anthropology shaped his unique approach to aesthetics and theatre. This article asks how he understood nature in theatre – more precisely, the possibility of producing a natural theatre during the Enlightenment, an age dominated by the celebration of reason. By examining Herder’s use of terms related to nature in multiple sources that have almost never been investigated – including some of Herder’s manuscripts, fragments, and short texts on theatre – this article shows that there is a link between Herder’s reflections on drama and theatre, nourished by his engagement with various disciplines, especially history, and the theatrical issues that would preoccupy his successors in the centuries to come. Herder’s conception of a natural theatre resonates in particular with Bertolt Brecht’s desire for the stage to represent the human condition as a historical process.
Marcia Noe. Three Midwestern Playwrights: How Floyd Dell, George Cram Cook, and Susan Glaspell Transformed American Theatre
Authors: Hernando-Real Noelia
Published: December 2023

This book argues that the origins of the Provincetown Players are to be found in Davenport, Iowa, where Dell, Cook, and Glaspell first encountered formative ideas around feminism, socialism, and free speech. Meticulously researched and original in its approach, it will be of interest to scholars of American theatre and Midwestern history.
Creating a collection of publications categorized by their research guarantors into the Scopus ASJC scheme
Authors: Álvarez-Llorente Jesús M. , Guerrero-Bote Vicente P. , De-Moya-Anegón Félix
Published: December 2023

Given the need in Scientometrics to get beyond merely classifying scientific production based on the classification of the journals in which it is published, there have been many attempts to classify papers directly. Little has been done, however, to check how reliable the results are. In this work, a collection of publications was generated which we call an Author’s Assignation Collection (AAC) comprising 13449 papers referenced in the Scopus database and classified by their research guarantor with fractional weighting in terms of Scopus’s own ASJC scheme. The methodological approach taken is described, and the collection’s representativeness is evaluated and compared with the journal-based classification. There stand out both the great number of papers assigned by their research guarantors to more than one category (at times with even the same weight) and how frequently authors assigned categories which were not assigned to the journals in which their paper was published.
Does Aspirin Provide Adequate Chemoprophylaxis for Venous Thromboembolic Events in Operative Pelvic and Acetabular fractures?
Authors: B. Metcalf Kathryn
Published: December 2023

Pelvic and acetabular fractures often result from high-energy mechanisms and represent unique treatment challenges. These fractures commonly occur with concomitant polytraumatic injuries and in the setting of significant medical comorbidities. Pelvic-acetabular trauma injuries are complex, frequently require surgical intervention, and carry a high risk of complications with sequelae leading to poor patient outcomes and large economic health-care burdens.
Assessment of the Outcome of Acetabulum Fractures by Open Reduction and Internal Fixation with Plating: A Retrospective Study
Authors: Dwivedi Amit
Published: December 2023

Introduction Acetabular fractures are one of the most challenging and complex injuries encountered by the orthopedic surgeons. Because the acetabulum involves a major weight bearing joint in the lower limb, these fractures are of great clinical importance. The main aim in such fracture management is the proper anatomical reduction for the good functioning of the hip joint. Aims and Objective In this study, our aim is to assess the outcome of the acetabular fractures operated by open reduction and internal fixation with plating. Materials and Methods In this retrospective study, we included 30 patients with acetabular injuries who needed surgical intervention as per the indications. The patients were selected according to the inclusion and exclusion criteria. The patients were operated between November 2019 to December 2020 at Yashoda Superspeciality Hospital, Nehru Nagar, Ghaziabad. Results Follow up of the patients was done at 6, 8 and 12 weeks and 6 and 12 months. The patients were assessed according to the Modified Harris Hip Score. Out of the 30 patients included in this study, 26 patients had excellent result, 3 patients had good result and 1 patient had fair result who developed stitch line infection which was treated with antibiotics. Conclusion All the patients operated had successful outcome with weight bearing, mobilization, and return to normal life and activities of daily living. Ilioinguinal, stoppa approach and KL approach have good outcome and the choice depends on the operating surgeon and the configuration of fracture.
Evaluation and Multidisciplinary Treatment of a Patient with Temporomandibular Disorder
Authors: Arano Hernández Agustín
Published: December 2023

Demonstrate that patients with signs and symptoms of the temporomandibular joint, prior to orthodontic treatment, should be treated multidisciplinary A 31-year-old female, a student at the Mexican Center for Stomatology, with a personal and family health history and orthodontic treatment who came to the clinic for presenting symptoms of pain in the face over the region of the bilateral temporomandibular joint, with alterations of the function, which radiated to the neck and back of several months of evolution. The clinical findings presented by the patient were: wear on the upper anterior teeth. The pain map diagnostic index was used, photographs of the face, whole body from the front and sides, panoramic radiography, lateral skull, anteroposterior and spine, articulated models in semi-adjustable articulator, this facilitated us to diagnose joint disorders. The proposed treatment was multidisciplinary treatment: Neuro-muscular rehabilitation and the use of physical agents, massage therapy, Kinesiology and manual therapy. The multidisciplinary treatment of occlusal guard by stomatology and the combination of physical agents, Kinesiology and manual therapy by physiotherapy, demonstrated excellent results with the disappearance of the symptoms in the patient, improved her expectations. Giving you a better quality of life.
Mehmed Eşref Dede ve Sûr-ı Tevhîd Çerâğ-ı Îmân İsimli Eseri
Authors: AK Murat
Published: December 2023

Mehmed Eşref Dede (1882-1962) Osmanlının son dönemi ile Cumhuriyet’in ilk yıllarında yaşamış, Osmanlıdan Cumhuriyet’e geçiş döneminde ortaya çıkan ictimai, siyasi ve iktisadi bütün değişimlere şahitlik etmiş sûfî ve şâir karakterlerden biri olarak karşımıza çıkar. Mehmed Eşref Dede hakkında bugüne intikal eden ilk bilgiler Hattat Emrullah Demirkaya’nın rika hattıyla yazdığı defterde ona ayrılmış kısımlarda yer alır. Mevlevîliğe intisap eden, çilesini tamamlayarak dede unvanını alan Mehmed Eşref Dede; İstanbul, Bursa, Kastamonu ve Konya’da bulunan Mevlevî tekkelerinde birçok vazife üstlenmiştir. Tekkelerin kapatılmasıyla ömrünün uzunca bir kısmında üstlendiği bu vazifelerden el çeken Mehmed Eşref Dede’nin son seneleri birçok zorlukla geçmiş, 1962 yılında Kastamonu’da kiraladığı hanenin odasında bakıma muhtaç bir hâlde vefat etmiştir. Hakkında yapılan çalışmalarda Mehmed Eşref Dede’ye ait Nüsha-i Kübrâ, Dîvân, Âyîn-i Tarîkat-ı Mevlânâ, Gıdâu’r-Ruhâniyye fî Tarîki’l-‘İrfâniyye, Hak Yolu, Sûr-ı Tevhîd Çerâğ-ı İmân isimli altı eser tespit edilmiştir. Bu eserlerden Nüsha-i Kübrâ üzerine bir yüksek lisans tezi hazırlanmış, Dîvân ve Âyîn-i Tarîkat-ı Mevlânâ isimli eserler ise neşredilmiştir. İlgili eserler içinde yer alan Sûr-ı Tevhîd Çerâğ-ı İmân Mehmed Eşref Dede’nin hakkında yeterince bilgi olmayan tek eseridir. Zira Mehmed Eşref Dede’yi konu edinen çalışmaların yalnızca birinde eser hakkında katalog düzeyinde bilgi verilmiş ve eserin aynı isimli başka bir Mehmed Eşref’e ait olabileceği ihtimali üzerinde durulmuştur. Bu çalışmada ilk önce Mehmed Eşref Dede’nin hayatı ve eserleri hakkında bilgi verilmiş, ardından kelime-i tevhîdin anlamları üzerine sûfî bakış açısıyla telif edilen Sûr-ı Tevhîd Çerâğ-ı Îmân isimli eserin Mehmed Eşref Dede’ye aidiyeti tespit edilmiştir. Söz konusu eserin telif sebebi, tertip hususiyeti, konusu, muhteva özellikleri ve kaynakları üzerinde duran çalışma, son dönem Mevlevîliğine ve Mevlevîlik literatürüne katkı sağlamayı hedeflemektedir.
Różne reakcje rodziców na przejawy złości dwu- i trzyletnich dzieci
Authors: Szczęsna Joanna , Wójtowicz-Szefler Małgorzata
Published: December 2023

Cel: Celem niniejszego artykułu jest zaprezentowanie różnych reakcji rodziców na przejawy złości dwu- i trzyletnich dzieci (reaktywnych metod wychowawczych) oraz ustalenie, które z czynników (wiek, płeć, wykształcenie i miejsce zamieszkania) różnicują reakcje rodziców na zachowania dziecka. Ponadto celem badania było ustalenie, jakie reaktywne metody wychowawcze stosują rodzice ze względu na rodzaj sytuacji, które odzwierciedlają behawioralne przejawy autonomii małych dzieci.
Metoda: Badanie kwestionariuszowe, które przeprowadzono na próbie 120 rodziców mających dwu- i trzyletnie dzieci (po 60 kobiet i mężczyzn). Wykorzystano autorski kwestionariusz, stworzony na podstawie teorii kryzysu trzeciego roku życia Lwa Wygotskiego (2002). Zadaniem osób badanych było opisanie swojej reakcji na behawioralne przejawy złości małego dziecka w siedmiu sytuacjach z życia codziennego (negatywizm, upór, krnąbrność, samowola, sprzeciw – bunt, deprecjacja i despotyzm).
Wyniki: Rodzice deklarowali korzystanie ze wszystkich reaktywnych metod wychowawczych – zarówno indukcyjnych, jak i imperatywnych (punitywnych i agresji psychologicznej) w reakcji na przejawy złości swoich dwu- i trzyletnich dzieci. Istotnymi predyktorami metod indukcyjnych i punitywnych okazały się wiek i poziom wykształcenia rodzica, natomiast dla agresji psychologicznej – jego płeć i miejsce zamieszkania. Z badania wynika, iż wyłącznie kobiety posługują się w relacji z dwu- i trzylatkiem agresją psychologiczną, której stosowanie jest tym częstsze, im bardziej zagrożony jest autorytet matki, a sprzeciw dziecka wobec jej woli staje się coraz bardziej wyraźny.
Konkluzje: Behawioralne przejawy autonomii dwu- i trzylatków są uwarunkowane naturalnym rozwojowo kryzysem trzeciego roku życia. To wyraz frustracji małego dziecka,  nie zaś przejaw zachowań agresywnych, który wymaga zastosowania przez rodziców odpowiednich metod wychowawczych. Na podstawie badania ustalono, że rodzice w głównej mierze deklarują równoczesne korzystanie z metod indukcyjnych i punitywnych, jednak im częściej dziecko przejawia autonomię, tym deklarowana skłonność rodziców do stosowania metod karzących wzrasta.
MODELING PERFORMANCE INDICATORS OF BUILDING CONSTRUCTION USING NON-REMOVABLE FORMWORK
Authors:   Odessa State Academy of Civil Engineering and Architecture, Russyi V.V. , Bochevar K.I. ,   Odessa State Academy of Civil Engineering and Architecture
Published: December 2023

This article is dedicated to modeling performance indicators of the comprehensive process of constructing a multi-story building while varying influencing factors, taking into account existing constraints, and utilizing modern software complexes. During the modeling process, the following solution for wall construction was employed as a component of the comprehensive building process: the installation of lightweight steel thin-walled structures (LSTW) with non-removable formwork cladding and filling with polystyrene concrete. Previous research has established that this construction and technological solution is the most effective among the compared alternatives. Building upon prior investigations, experimental-statistical modeling of the «construction duration», «construction cost», «average intensity of funding», and «maximum intensity of funding» indicators was performed, varying factors such as the «overlap coefficient of processes» and «number of working hours per week». Modeling was conducted using the COMPEX software complex. The values of efficiency indicators were obtained according to selected experimental plans by constructing economic (budgetary calculations) and organizational-technological (work performance schedules) models using the AVK 5 and Microsoft Project software complexes, respectively. During the experimental-statistical modeling, extremes of efficiency indicators and corresponding values of factor combinations influencing them were determined. The nature and degree of the factors' impact on the investigated efficiency indicators were identified. The «construction cost» indicator was subjected to an existing constraint in the form of using credit funds. The calculation of the impact of imposing this existing constraint was performed in the Microsoft Excel software complex. While varying the factorial space, diagrams of changes in the budgetary cost of building construction and the amount of funds needed to secure the loan were constructed. Combining these diagrams resulted in values for the «construction cost with consideration of credit funds». It was determined that the use of credit funds at a level of 90% significantly increases the cost of building construction. On average, this increase amounted to 183,8 million UAH. Graphical dependencies were constructed using the CorelDraw X6 software complex.
TRENDS AND PROSPECTS OF MODERNISATION OF MULTI-STORY RESIDENTIAL BUILDINGS ON THE BASIS OF SUSTAINABLE DEVELOPMENT
Authors:   National Academy of Fine Arts and Architecture, Derkach S.I.
Published: December 2023

According to the results of generalisation; quantitative, qualitative and comparative analysis of the reconstruction of residential buildings, trends and prospects for the reconstruction and modernisation of multi-story residential buildings are determined, considering the principles of sustainable development. The problems, trends and prospects of the reconstruction of multi-story buildings were determined, which made it possible to find optimal ways of modernising residential buildings, considering controversial issues, opportunities and goals of sustainable development. The controversial issue is to find a balance between real opportunities, current and planned projects and ways of implementation, considering economic opportunities, legislation and controversial issues between Condominium and co-owners of multi-apartment buildings. The problems are highlighted and ways to solve the improvement of projects for the modernisation of multi-story buildings are found. Possibilities and options for cost-effective modernisation of multi-story buildings are taken into account. The interests of all stakeholders were taken into account and ways to overcome misunderstandings were found. When all issues are resolved, not only the interests of the project executor, the Condominium, co-owners of multi-apartment building, organisations and funds which financing the project, as well as the capabilities of the state and current legislative and regulatory acts regulating the financing and implementation of the project of modernisation of multi-story buildings are taken into account. Much attention is allocated to the goals of sustainable development of cities and communities. After all, when modernising multi-story buildings, it is necessary to focus not only on the needs of the present, but also to considering the needs of future generations and focus on effective, economically profitable prospects of the present and the distant future, taking into account the need for a healthy environment. Thanks to the amendments to the legislation, it became possible to improve the energy efficiency of buildings and reach a higher quality level in the modernisation of multi-story buildings.
STUDY OF THE LOAD-BEARING CAPACITY OF STRUCTURES of LONG-TERM OPERATION OF THE FORMER "MODULE" PLANT IN UZHGOROD
Authors:   National University ", Karkhut I.I. ,   Lviv Polytechnic", Luchko J.J. ,   Lviv National Agrarian University
Published: December 2023

In this work, based on an analysis of literary scientific and technical sources and completed field studies, the problem of degradation of reinforced concrete and metal structures of long-term operation is formulated and its relevance is noted. The authors analyzed a number of works on this issue. Examples of the use of modern methods and materials for strengthening reinforced concrete and stone structures with damage and defects to restore their load-bearing capacity are described. The paper presents the results of a visual review and instrumental study of reinforced concrete and metal load-bearing structures of the former “Modul” plant, built according to the II-03с and II-60с series, as well as external self-supporting expanded clay concrete wall panels, brick walls, staircases and partitions. General information about the building and its design is provided. The objectives of the study included establishing the actual technical condition of the building’s structures and the possibility of its subsequent reliable operation after repurposing. During the examination, non-destructive testing methods and laboratory tests of materials were used to obtain actual strength indicators, humidity, the degree of corrosion damage to materials, and geometric characteristics of structures for their identification. The main reasons that necessitated the research and development of recommendations for eliminating identified defects and damage, as well as shortcomings of long-term operation, have been identified. Data are provided on detected defects and damage that occurred over a long period of time. According to current standards, the general technical condition of the building has been established as satisfactory (category 2) and appropriate conclusions have been formulated regarding the need for repair work. Based on the results of field surveys, relevant calculations and conclusions, recommendations for the repair and elimination of identified defects and damage were developed.
ACTIVATION OF CEMENT AND ITS INFLUENCE ON STRUCTURE FORMATION OF CEMENT-CONTAINING COMPOSITIONS
Authors:   Odessa State Academy of Civil Engineering and Architecture, Barabash І.V. , Pirogov D.О. ,   Odessa State Academy of Civil Engineering and Architecture
Published: December 2023

The article discusses issues related to the mechanochemical activation of the cement binder in a specially designed rotary counterflow mill. The given brief description of the design of a counterflow mill gives a general idea of the principle of its operation as an activator of the surface zone of a mineral binder. Typically, a positive characteristic of mineral binders is their rapid increase in strength. Therefore, scientific research related to the development of technology aimed at intensifying the processes of structure formation of cement paste and stone based on it is relevant. The use of this technology makes it possible to significantly increase the specific surface area of cement during its activation, reduce the setting time, increase the amount of chemically bound water and intensify the exothermic heating of hardening cement stone. The presented experimental data made it possible to optimize the activation period of the binder, which ranged from 60 to 600 seconds. It has been established that the optimal time from the point of view of the energy intensity of the process is the activation period of the binder for 300 seconds. During this activation period, there is an increase in the specific surface area of cement by an average of 8...10%, acceleration of setting time by 50...60 minutes, an increase in the amount of chemically bound water at 28 days of age from 13 to 16.3%, an increase in the maximum temperature of exothermic heating cement stone from 53.8 to 64.0 °C. A further increase in the activation period (up to 600 seconds) has little effect on the change in the listed properties. The effect of mechanochemical activation is significantly reflected in the compressive strength of cement stone. It has been established that activation of cement for 300 seconds causes an increase in the compressive strength of cement stone from 48 to 57 MPa, that is, by almost 20%. The effect of mechanochemical activation of cement is enhanced by the introduction of quartz sand into its composition. It has been experimentally established that the activation of cement with the addition of 20% quartz sand increases the strength of the filled cement stone by almost 30% relative to the strength of the stone using unadded cement that is not subject to mechanical activation.
Halk Eğitimi Merkezi Bünyesinde Açılan Kursların, Kursiyerler ve Kurs Öğretmenleri Tarafından Değerlendirilmesi: “Trabzon İli Örneği”
Authors: GOZUBUYUK TAMER Mine
Published: December 2023

Bu araştırma ile Trabzon ili Ortahisar ilçesinde Halk Eğitim Merkezi bünyesinde açılan kursların, kursiyerler ile kurs öğretmenleri (usta öğreticiler) tarafından değerlendirilmesi amaçlanmıştır. Bu amaçla, yetişkinlere yönelik kurslara (sanat ve tasarım, el sanatları vb.) katılan kursiyerlerin genel görünümlerinin belirlenmesi, kurs deneyimlerinin (kurs hakkında genel bilgi, kursa katılma nedenleri, kurslara katılımın bireysel/gündelik ve sosyal yaşamlarına katkısı, ilgililere öneri ya da tavsiyeler vb.) ortaya konması ile usta öğreticilerin deneyimlerinden hareketle kursların değerlendirilmesi hedeflenmiştir. Çalışmanın anlaşılmasına temel oluşturmak ve anlam karmaşıklığını gidermek amacıyla çalışmada sıkça kullanılan kavramlara- yaygın eğitim, halk eğitimi, yetişkin eğitimi vb.- yer verilmiştir. HEM bünyesinde açılan kurslara katılan kursiyerler genelde ‘yetişkin’ grubuna girdiğinden kurs süreçleri yetişkin eğitimi ve öğrenimiyle ilgilenen yaklaşımlar üzerinden anlaşılmaya çalışılmıştır. Bu kapsamda, öncelikle tarihsel süreçte yetişkin eğitimi konusunda yapılan çalışmalara kısaca değinilmiş ardından Malcolm S. Knowles’ın “Andragoji Teorisi”ne yer verilerek konunun kuramsal zeminde işlenmesine yönelik bir yol haritası sunulmuştur. Araştırmanın saha boyutunun gerçekleştirilmesini teminen nitel araştırma yöntemine bağlı kalınarak fenomenolojik desen kullanılmıştır. Araştırmanın çalışma grubu Trabzon İli Ortahisar İlçesi Halk Eğitim Merkezi’nin çeşitli kurslarına (sanat ve tasarım, el sanatları vb.) devam eden 24 gönüllü kursiyerden ve altı usta öğreticiden oluşmuştur. Araştırmadan elde edilen veriler, derinlemesine görüşme tekniğiyle toplanmış ve betimsel analiz tekniğiyle analiz edilmiştir. Araştırma sonuçları paylaşılmış ve öneriler sunulmuştur.
INVERSE PROBLEM ON DETERMINING MANY UNKNOWNS FROM SCHWARTZ-TYPE DISTRIBUTIONS
Authors: Lopushanska H. , Myaus O. , Pasichnyk O.
Published: December 2023

We find the sufficient conditions for the unique (local in time) solvability of an inverse problem of finding m unknown functions $R_l(x)$, $l\in \{1,\dots,m\}$ from the Schwartz-type distributions $S'_{\gamma,(a)}(\Bbb R^n)$ in a source term of a diffusion equation
\[D^{\beta}_t u-A(x,D)u=\sum\limits_{l=1}^mR_l(x)g_l(t)+F(x,t), \;\; (x,t) \in Q=\Bbb R^n\times (0,T] \]
with the Djrbasian-Nersesian-Caputo time-fractional derivative of the order $\beta\in (0,1)$ where $A(x,D)$ is an elliptic differential operator of the second order,
\[S_{\gamma,(a)}(\Bbb R^n)=\{v\in C^\infty(\Bbb R^n): ||v||_{k,(a)}=\sup\limits_{|\alpha|\le k,x\in \Bbb R^n}e^{a(1-\frac{1}{k}) |x|^{\frac{1}{\gamma}}}|D^{\alpha}v(x)|<+\infty\;\;\forall k\in \Bbb N, k\ge 2\}.\]

We use time-integral over-determination conditions
\[\frac{1}{T}\int_{0}^{T}u(x,t)\eta_l(t)dt=\Phi_l(x), \;\;x\in \Bbb R^n,
\;\;l\in \{1,\dots,m\}\]
with the given $\eta_l\in C^1[0,T]$ and Schwartz-type distributions $\Phi_l(x)$, $l\in \{1,\dots,m\}$. Note that time-integral over-determination conditions were used in the study of various inverse problems in various functional spaces.

By properties of the Green vector-function the problem boils down to solving linear operator equation of the second kind with respect to the unknown solution $u$ of the Cauchy problem, continuous with values in Schwartz-type distributions, and a linear inhomogeneous algebraic system of equations for finding expressions of unknown functions $R_l(x)$, $l\in \{1,\dots,m\}$ through it. We generalize the results of [11] on the classical solvability of a problem with two unknown functions from Schwartz-type spaces of rapidly decreasing functions at infinity on the right-hand side of such an equation.
Changes in some quality properties of frozen mare milk during 6 months of storage
Authors: Barukčić Jurina Irena , Miletić Ivan , Božanić Rajka , Jurina Tamara , Leboš Pavunc Andreja , Lisak Jakopović Katarina
Published: December 2023

The aim of this study was to determine how storage in the frozen state affects the quality of mare milk. Therefore, physicochemical properties such as pH, total dissolved solids (TDS), electrical conductivity (EC), particle size distribution and near-infrared (NIR) spectroscopy, as well as changes in antioxidant activity and the total phenol content were determined during 6 months of storage at -18°C. All of the determined parameters were compared to those in raw mare milk prior to freezing. According to the obtained results, frozen storage caused certain changes in mare milk quality, including increase in pH, electrical conductivity and TDS values, changes in protein structure recorded by NIR spectroscopy and SDS PAGE (Sodium dodecyl sulfate-polyacrylamide gel electrophoresis), as well as changes in particle size distribution. There was also a continuous decrease in the antioxidant activity and the total phenol content of frozen mare milk throughout the 6 months of frozen storage. Thus, after 6 months of frozen storage, a decrease in the DPPH value of approximately 59%, in the FRAP value of approximately 26% and in the TPC of approximately 70% was observed, respectively. In conclusion, freezing and frozen storage affected the quality of mare milk, which might have negative consequences on its therapeutic value.
Deciphering the Molecular Basis of Mutated Binding Site Bromodomain-Ligand Complexes: Insights from Molecular Dynamics Simulations and Decoded Interaction Fingerprint Analysis
Authors: Riandono Fransiscus Deddy
Published: December 2023

This study aims to predict structural stability changes and to identify the molecular determinants of ligand-bromodomain complex interactions that undergo mutations in the ligand binding site (LBS) using computational chemistry methods. The stability changes of the complexes were investigated using Molecular Dynamics (MD) simulations during a 25 ns production run. The identification of molecular interaction determinants was performed by decoding the interaction fingerprint, utilizing the output of trajectory data of the MD simulations, which were converted into a series of pdb files along the time step. The system preparations were done using CHARMM-GUI. The MD simulations were carried out using the GROMACS program. Protein-ligand interaction fingerprints (PLIF) were identified using the PyPLIF-HIPPOS program. This study successfully predicted the stability of both wild-type and mutated ligand-bromodomain complex structures, where the W81A mutation led to a decrease in complex stability. The key residues and non-hydrophobic interaction types responsible for the stabilities were identified as TRP81 aromatic edge-to-face, TYR139 aromatic edge-to-face, and TYR139 aromatic face-to-face.
Legality of Agricultural Products Weight Cutting as a Cost of Risk in Trade
Authors: Arianti Farida , M Pauzi , Mughits Abdul , Nurdin Ridwan , Saad Abdo Yousef Qaid
Published: December 2023

Agricultural goods transactions with toke (in Bahasa is known as a traditional market agent) always carry a weight cutting of one to 2 kilograms per bag. Risk reduction is considered a burden to be borne. Therefore, how to study the law in the aspect of risk imposition when transactions occur between plantation farmers and toke in traditional markets. The aim of this research was to examine how weighing is carried out and the recognition of the weight of agricultural products on scales is associated with possible risks that will occur in the future. This research method was qualitative, field research. Data sources were garden sellers/farmers and toke in traditional markets. Data collection through interviews and examination of artifacts. Data analysis technique was qualitative descriptive. The research finding showed that when the agricultural harvest was sold, there was a scale cut of around 2 kg per bag, such as chilies, ginger, corn and so on. The result of reducing the scale in dealing with the risks that will occur with irregular goods. The risk was borne by the farmer/seller, this was suspected and endangers the continuity of the relationship between farmer, toke, retailer towards objects that change naturally. Cutting the weight of the scales was still permitted as long as it was within appropriate limits. Recommendations for cutting the weight of the scales when changing goods and not fixed goods.
Violence against Women: Comparing Female Genital Mutilation and Female Circumcision in Malaysia
Authors: Mohd Ithnin Norazam Khair , Suliaman Ishak , Ibrahim Abdul Halim
Published: December 2023

The United Nations (UN) General Assembly resolution on 20 December 2012 declared female genital mutilation (FGM) illegal and a violation of women's rights. This declaration was made following the World Health Organization's (WHO) call to eradicate FGM in 1997. The prohibition includes all forms of mutilating, harming, or causing pain to the female genitalia. The female circumcision practice in Malaysia is also categorized as FGM by the United Nations Human Rights (UNHR) at the Convention on the Elimination of All Forms of Discrimination against Women (CEDAW) in 2018. In light of these developments, this qualitative study examines and compares the true nature and concepts of FGM and the female circumcision practice from the perspective of Al-Sunnah Al-Nabawiyyah. Documentation was employed for data collection, analysis, and interpretation. The findings reveal a significant divergence between FGM and female circumcision. Female circumcision is more similar to the aesthetic surgery of the female genitalia, known as clitoral hood reduction, which can enhance women's sexuality. In conclusion, female circumcision in Malaysia is not a torturous act that violates women's rights, but rather a safe practice following Islamic law. This study also proposes a comprehensive research initiative aimed at formulating secure and Sharia-compliant protocols for female circumcision.
Examining Call for the Dissolution of Indonesian Ulema Council: Siyāsah Syar’íyyah Perspective
Authors: Syatar Abdul , Imran Muhammad , Ilham M , Kurniati Kurniati , Marilang Marilang , Marjuni Kamaluddin Nurdin
Published: December 2023

The religious authoritative institution of the Indonesian Ulema Council (MUI), is facing infiltration by members connected with acts of terrorism. This leads to public demands for its dissolution under the banner of "Joint Enemy Terrorism". Therefore, this study aimed to assess the possibility of dissolving MUI by reviewing the root causes of terrorism within the religious institution. Through the lens of Islamic political analysis and a critical examination of various data sources, it became evident that the discourse advocating for the dissolution centered around the hashtag #BubarkanMUI#. This hashtag campaign was initiated to frame the participation of MUI members in extremist activities, thereby posing a threat of criminal terrorism. MUI, on the other hand, was beyond dispute due to its strong and legally entrenched position. In this context, the prospect of the dissolution became irrelevant, impractical, and challenging to materialize primarily due to membership issues. The existence of MUI was strengthened and secured through several laws mandating its engagement, including the certification of halal products and regulation of Sharia banking. This showed the religious institution must embark on a thorough evaluation and enhancement of both its structural framework and membership recruitment processes. Regarding the authority to dissolve non-political institutions and organizations, this prerogative should be entrusted to the Constitutional Court, serving as a judicial entity responsible for safeguarding democracy, human rights, and constitutional principles.
Underage Widows and Widowers before the Law: Problem, Contestation and Legal Certainty in Marriage Dispensation
Authors: Faiz Muhammad Fauzinudin , Ali Zezen Zainul , Taufiq Muhammad
Published: December 2023

Increasing the minimum age for marriage has increased the community's efforts to obtain a marriage dispensation permit in court. Generally, this application is made by children who are not old enough and not yet married, but the facts on the ground state that there are widows and widowers under age who also apply for a marriage dispensation for the second time, this raises a new problem, namely legal uncertainty for the applicant. This study will explore the problems of an underage widow and widower in registering his second marriage and the contestation of authority in the marriage of underage widows and widowers. The study was conducted by looking at and analyzing several cases of application for dispensation for the marriage of underage widows and widowers in several Religious Courts (juridical normative) and mapping related documents (library research). Three important points are noted. First, when a widow and widower under the age of 19 applies for marriage registration at the Office of Religious Affairs but is refused and directed to apply for a dispensation to marry, while in the Religious Court, there are differences of opinion among judges in the application for dispensation to marry a second time, some reject, and some accept. Second, there is contestation between the Office of Religious Affairs and the Religious Courts in viewing dispensation for widow and widower marriage because of the different legal basis used. Third, despite the contestation between the two institutions, the Religious Courts, as justice-seeking agencies, must accept the application submitted to ensure legal certainty for its citizens, namely widows and widowers under age. Thus, this article recommends two actions: namely, the need for communication between the two executive and judicial institutions to discuss the issue of marriage dispensation for underage widows and widowers so as not to contradict each other and legal certainty for underage widows and widowers who want to marry is essential.
The determination of sarcopenia in older adults using a practical measure
Authors: Chokphukiao Pakwipa , Amatachaya Sugalya , Poncumhak Puttipong , Intaruk Roongnapa , Thaweewannakij Thiwabhorn , Somboonporn Charoonsak , Peungsuwan Punnee , Amatachaya Pipatana , Sooknuan Thanat
Published: December 2023

BACKGROUND: Many older adults are at risk of sarcopenia, a gradual loss of muscle mass affecting muscle strength and physical function, which can lead to adverse health consequences deteriorating their independence. However, the detection could be delayed due to the requirement of many measures, including a complex imaging modality. Thus, an exploration for a practical community- or home-based measure would be helpful to identify at-risk older adults and begin the timely management. OBJECTIVE: To explore the ability of the upper limb loading during a seated push-up test (ULL-SPUT) to determine the presence of sarcopenia in community-dwelling older adults. METHODS: Older adults (n= 110; 62 females, average age approximately 77 years) were cross-sectionally assessed for sarcopenia using standard measures (handgrip strength, appendicular skeletal muscle mass, and walking speed) and the ULL-SPUT. RESULTS: Data from standard measures indicated that 44 participants had sarcopenia. The ULL-SPUT index of < 16.9 kg/m2 for females (sensitivity = 86%, specificity = 78%, area under the receiver operating characteristic curve [AUC] = 0.85) and < 19.7 kg/m2 for males (sensitivity = 73%, specificity = 69%, AUC = 0.83) could optimally identify participants with sarcopenia. CONCLUSION: The ULL-SPUT index could be used to screen and monitor older adults with sarcopenia in various clinical, community, and home settings. This practical measure may be accomplished using a digital bathroom scale on a hard, even surface. Outcomes would identify an adult who should undergo further confirmation of sarcopenia through standard measures or the initiation of timely management to promote treatment effectiveness.