bluuebunny/crossref_metadata_2025 huggingface dataset:
Germinação e condutividade elétrica de sementes de Schinus terebinthifolius (Anacardiaceae)
Authors: Shibata Marilia , Corredor-prado Jenny Paola Corredor , De Oliveira Luciana Magda
Published: October 2019

A principal forma de propagação de Schinus terebinthifolius é por sementes, contudo pouco se conhece sobre os testes para a avaliação da qualidade fisiológica das sementes dessa espécie. Os objetivos do presente trabalho foram avaliar a influência da temperatura no teste de germinação em sementes de S. terebinthifolius e verificar a eficiência do teste de condutividade elétrica. Sementes de três lotes foram submetidas a teste de germinação nas temperaturas de 20ºC e 25ºC e a testes de vigor: índice de velocidade de germinação, tempo médio de germinação, comprimento de plântula e condutividade elétrica, com leituras após 0, 2, 4, 6, 8, 10, 12, 24, 26 e 28 horas de embebição. Obtiveram-se plântulas mais vigorosas e resultados superiores para o índice de velocidade de germinação, tempo médio de germinação e comprimento de plântulas na temperatura de 25ºC. No teste de condutividade elétrica, após 10 horas de embebição, as leituras foram estabilizadas e permitiram a comparação entre lotes. A temperatura de 25ºC é mais adequada para a condução do teste de germinação de sementes de S. terebinthifolius, e o teste de condutividade elétrica não é recomendado para a análise da qualidade fisiológica das sementes de tal espécie.
Levantamento florístico de plantas medicinais de um fragmento de campos de altitude da mata atlântica
Authors: Martí Moreira da Silva Iberê , Arantes de Barros Dalmo , Coelho Junior Marcondes Geraldo , Leandro de Oliveira Athila , Ribeiro Carvalho Rita de Cássia , Geraldo de Carvalho Acacio
Published: October 2019

A mata atlântica apresenta uma grande biodiversidade de espécies vegetais, algumas ameaçadas. Com usos diversos, muitas sofrem com a pressão humana e pela ausência de manejo de áreas relevantes no bioma. O objetivo do presente estudo foi realizar o levantamento florístico de um campo de altitude sobre corpos de bauxita, identificando espécies com potencial medicinal, no município de Poços de Caldas, Minas Gerais. Fez-se uma revisão de literatura dessas espécies, inferindo sobre sua respectiva importância no uso popular, seus componentes químicos e sua atividade biológica. Identificaram-se 42 espécies com potencial medicinal, distribuídas em 19 famílias, com destaque para Asteraceae (22 espécies). Do total de 42 espécies com potencial medicinal, 39 foram relatadas na literatura quanto ao seu uso popular, 37 têm seus componentes químicos estudados e 27 apresentaram registros de pesquisas com aspectos relacionados à atividade biológica. Percebeu-se a questão de diferença de gênero e de diferença etária em relação ao conhecimento sobre plantas medicinais. Verificou-se que as pesquisas sobre plantas medicinais são fragmentadas e realizadas em menor escala. A elaboração de planos de manejo sustentáveis de produtos não madeireiros com potencial medicinal é uma estratégia para conservar a sociobiodiversidade da mata atlântica.
The Role of Thyroid Diseases and their Medications in Cardiovascular Disorders: A Review of the Literature
Authors: Omidi Negar , Khorgami Mohammadrafie , Tajrishi Farbod Z. , Seyedhoseinpour Amirhosein , Pasbakhsh Parichehr
Published: October 2019

The association between thyroid disease and cardiovascular manifestations is significant and undeniable. Previous studies have explained several aspects of the effects of thyroid hormone on the heart and cardiovascular system. Accordingly, both hyper and hypothyroidism can cause important alterations in cardiac rhythm, output and contractility as well as vascular resistance and blood pressure. Since treating the thyroid abnormality, especially in its initial stages, could lead to a significant improvement in most of its resultant cardiovascular disturbances, early suspicion and recognition of thyroid dysfunction, is necessary in patients with cardiovascular manifestations. In this in-depth review, we discuss the physiological roles as well as the effects of abnormal levels of thyroid hormones on the cardiovascular system. We also review the effects of the medications used for the treatment of hyper and hypothyroidism on cardiac function. In the end, we discuss the association between thyroid function and amiodarone, an effective and frequently-used antiarrhythmic drug, because of its well-known effects on the thyroid.
Clinical Evaluation of Febrile Thrombocytopenia in Western Rajasthan - a Hospital-based Study
Authors: Choudhary Sahadev , Kumar Deepak , Bohra Gopal K. , Gupta Alok , Meena Durga S. , Rathore Rajkumar Singh , Bhambu Sunil K.
Published: October 2019

:

A number of patients of febrile thrombocytopenia increase during monsoon and postmonsoon
period. Diseases like dengue fever, malaria, chikungunya fever, etc. are responsible for
the clustering of febrile thrombocytopenia cases during this period. The diagnosis of fever with
thrombocytopenia cases can be challenging and physicians should be aware of the regional and
endemic seasonal cause of this syndrome.

Study Design:

It is a prospective observational study.

Material and Methods:

The study included 103 consecutive patients. The patients admitted with
acute febrile illness defined by a duration of less than 2 weeks with thrombocytopenia were evaluated.

Results:

The present study included 103 consecutive cases of febrile thrombocytopenia. Out of
these, 71.84% were male and 28.16% were female. The most common etiology for febrile thrombocytopenia
was dengue fever (44.66%) and malaria (31.06%). Among clinical evaluation of the
cases, fever was the inclusion criteria. Myalgia was the most common symptom found after fever,
which was observed in 83.5% of the patients. The most common bleeding manifestation was petechiae/
purpura (12.62%) followed by hematuria (6.80%). Renal dysfunction was present in all
8(100%) cases of sepsis, followed by 14(43.75%) cases of malaria. All sepsis cases also had liver
dysfunction, followed by 91.3% cases in dengue fever and 90.62 % cases in malaria had liver dysfunction.

Conclusion:

The study showed that acute febrile thrombocytopenia is an important seasonal syndrome.
The common causes are dengue fever and malaria. Early identification of these diseases
and prompt treatment decreases complications and reduces mortality.
La reparación de víctimas en el marco de la implementación de un proceso de Justicia Transicional
Authors: Camargo García Katterin Viviana
Published: October 2019

El presente documento analiza la reparación de víctimas en la implementación de un proceso de justicia transicional por violaciones a los derechos humanos y delitos de lesa humanidad. Asimismo, contempla los tipos de reparación establecidos a nivel internacional y los componentes que se deben tener presentes para lograr una reparación integral con el objetivo de superar los efectos morales y físicos causados por un conflicto armado interno. La investigación contempla una metodología de análisis cualitativo-descriptivo que se despliega en tres focos: 1) componentes para la reparación de víctimas en el proceso de justicia transicional, 2) tipos de reparación de víctimas establecidos a nivel internacional para un conflicto armado interno y 3) la reparación de víctimas como un mecanismo para superar el conflicto armado interno.
Geopolítica del Polo Sur
Authors: Alvarez Calderon Carlos Enrique , Namen Mesa Eduardo
Published: October 2019

Después del espacio exterior y el fondo oceánico, el continente antártico sería la última frontera relativamente inexplorada de la humanidad. En efecto, la importancia geopolítica del Polo Sur viene en franco aumento desde que los desarrollos militares, las exploraciones sucesivas y el establecimiento de estaciones de investigación han puesto la Antártida en el centro de las consideraciones estratégicas de los Estados. Si se toma en consideración que la dinámica de la geopolítica antártica es un eco de otras existentes en el sistema internacional, este podría ser el momento preciso para que Colombia cuente con una visión de futuro al respecto e implemente acciones concretas para proyectar el desarrollo de los intereses del Estado hacia otras latitudes, tal como lo han hecho históricamente otros Estados.
Pengaruh Thermal Shock Resistence dan Komposisi Bahan Refraktori Terhadap Kekuatan Impact dan Struktur Makro
Authors: Sari April Lianita , Rusiyanto Rusiyanto
Published: October 2019

The purpose of this research is to study the effect of thermal shock and the composition of refractory materials on impact strength and macrostructure. The research methods are an experimental method. The independent variables in this research are thermal shock temperatures and the composition of refractory materials (a portion of alumina, rice husk ash and kaolin). The dependent variables in this research are impact strength and macrostructure. The data of this research is analyzed using descriptive statistic. The results are presented in tables, charts and images. The result shows that the highest value of average impact strength is 0,009560 J/mm2 with 300 °C temperature of thermal shock (∆T). The result of the macrostructure is a brittle structure with flat and shiny surface characteristics.Tujuan dari penelitian ini adalah mengetahui pengaruh thermal shock dan komposisi bahan refraktori terhadap kekuatan impact dan struktur makro. Metode yang digunakan pada penelitian ini merupakan metode eksperimen. Variabel bebas yang digunakan dalam penelitian ini yaitu variasi suhu thermal shock dan variasi komposisi bahan refraktori (alumina, abu sekam padi dan kaolin). variabel terikat yang digunakan dalam penelitian ini yaitu kekuatan impact dan struktur makro. Teknik analisis data yang digunakan adalah analisis deskriptif. data hasil penelitian disajikan dalam bentuk tabel, grafik dan gambar. Hasil penelitian menunjukkan bahwa rata-rata kekuatan impact tertinggi sebesar 0,009560 J/mm2 diperoleh pada komposisi 5 tanpa perlakuan thermal shock dan terendah sebesar 0,004049 J/mm2 dengan variasi suhu thermal shock (∆T) 300 oC dan hasil foto makro menunjukkan patahan getas dengan ciri-ciri permukaan patahan yang datar dan terlihat mengkilap
El archivo del cabildo colonial de la Ciudad de México. Fundación y símbolo de un nuevo orden
Authors: Rubio Hernández Alfonso
Published: October 2019

Tomamos como modelo los momentos iniciales de la fundación de la Ciudad de México en el siglo XVI para interpretar, desde unas coordenadas prácticas y simbólicas, la función del archivo o arca de tres llaves que la institución del Cabildo, Justicia y Regimiento de la ciudad estaba por ley obligada a instalar. La tradición burocrática que la Corona española traslada al Nuevo Mundo instaura mecanismos que desde el diseño de la traza urbana, la edificación del cabildo y el funcionamiento en él del arca de tres llaves legitiman un nuevo orden y garantizan la adhesión de la población a la administración hispana. Son estos mecanismos los que desde la documentación que custodia el propio archivo del cabildo fundacional, hoy en día en el Archivo Histórico de la Ciudad de México, y desde una bibliografía que nos da pautas de interpretación, intentamos analizar en este texto.
Forced “Occupational Therapy” in the USSR: between the Gulag and “Big Chemistry”
Authors: Зубкова Елена , Zubkova Elena
Published: October 2019

The paper focuses on the process of transformation of ideas and practices of social control in the USSR in the 1950s-1960s in relation to various categories of people named as “persons with an antisocial way of living” (lazy freeloaders). This process was reflected in the liberalization of the criminal law and punishment practices, as well as in the changing attitudes towards people with deviant behavior. The study focuses on the social category of “lazy freeloaders” and the discourse of forced labor construed as “occupational therapy” (when applied to “lazy freeloaders”). The transformation of social control norms and practices is described in the context of socio-political changes during the “thaw” period helping to raise questions that are more general: quality and limits of the Soviet system’s viability, its ability to face the challenges of time, adapt to changing social realities and new public sentiments. The paper is based on some new archival sources, as well as on the materials of the Soviet press.
5th International Seminar of Young Tibetologists (St. Petersburg, 3–7 September, 2018)
Authors: Гроховский Павел , Grohovskiy Pavel , Москалёва Наталья , Moskaleva Natal'ya , Смирнова Мария , Smirnova Mariya
Published: October 2019

St. Petersburg State University hosted the 5th International Seminar of Young Tibetologists. Bringing together researchers from different countries, this regular interdisciplinary conference was the first major international academic Tibetology event held in Russia. The paper describes the scientific topics of the conference sections, gives an overview of the scientific findings and reveals their importance for national science.
Anticipative Consistency within the System of Predictors of Academic Progress and Students’ Subjective Well-Being
Authors: Даниленко Ольга , Danilenko Ol'ga
Published: October 2019

Anticipative consistency (AC) and several personal characteristics (e.g., self-efficacy, vital capacity, optimism, trait anxiety) were studied as personal adaptative resources involved in subjective well-being and academic progress of graduate students. More than 600 graduate students of different specialities were interrogated at various stages of the study. To obtain data on subjective well-being, the author used Subjective Well-Being Scale and Satisfaction With Life Scale. An average study grade was an academic progress indicator. To determine significance of personal variables, General Self-Efficacy Scale, Dispositional Optimism Test, Life-Purpose Orientation Test, Vital Capacity Test and Trait Anxiety Scale were used. To process obtained data, frequency study, exploratory factor analysis, confirmatory factor analysis, correlation analysis and multivariate regression analysis were applied. Student AC factor model includes five elements (i.e., discipline, precaution, learning activity self-direction, success self-rating and mind-body self-regulation). A developed AS-VUZ-2 questionnaire enabled collection of data on the element intensity and general AC of students. Regression analysis revealed that significant positive predictors of subjective well-being include general AC of students and self-efficacy. A subject’s trait anxiety is a significant negative predictor. Several elements of a student’s AC (i.e., precaution and learning activity self-direction), as well as parameters demonstrating a subject’s confidence for life circumstance control and trait anxiety have a positive contribution to academic progress. Parameters indicating self-fulfillment satisfaction and a factor demonstrating a subject’s risk to acquire new experience represent significant negative predictors. Considered as a student’s AC element, precaution has the most significant positive impact on academic progress as compared with all the considered variables.
International Scientific Conference “Archaeology of the Ancient Rus: Issues and Discoveries” (the 100th Anniversary of D.A. Avdusin’s Birthday) (Moscow, November, 22–24, 2018)
Authors: Ениосова Наталья , Eniosova Natal'ya
Published: October 2019

The article contains review of reports submitted to the international conference. The mee­ting topic was attributed to broad academic interests of D.A. Avdusin (i.e., the greatest scholar dealing with the Ancient Rus archaeology, researcher of Gnezdovo archaeological complex and medieval Smolensk). Several topics (such as ancient Russian exequies, initial phases and methods of urbanization of various areas, regional and international relations, trade route generation, social and political aspects of primary power centre formation in medieval Rus, as well as issues related to life support, household, industrial art and culture in cities and villages) were discussed in 6 workshops.
Russian National Conference with International Participants “Specific Integration of Humanitarian and Technical Knowledge” (Moscow, September, 27–28, 2018)
Authors: Молокова Татьяна , Molokova Tat'yana , Бернюкевич Татьяна , Bernyukevich Tat'yana
Published: October 2019

The paper is focused on primary topics and issues discussed on the plenary and the affiliated sessions of the conference. In particular, they were related to connection and interaction of humanitarian and technical knowledge; opportunities, types and perspectives of their integration; significance of the humanities in a technical higher education institution. An efficient exchange of scientific data and exciting suggestions concerning state of Russian and foreign researches of technical and humanitarian knowledge interaction, development of scientific branches presented in the meeting, necessary focus on significance of the humanities in technical education. Opportunities and perspectives of interregional and international scientific educational coope­ration were determined.
“How the Fourteenth Division Got to Heaven” by Demyan Bedny: from a Poem to a Play
Authors: Фёдоров Максим , Fedorov Maksim
Published: October 2019

For the first time in the Russian science, the research focuses on the drama of Demyan Bedny. It dwells upon the works of the poet, which were staged. Using the archived materials of the manuscript department of the Institute of World Literature, the author shows the history of the play by Demyan Bedny “How the Fourteenth Division Got to Heaven” and explores one of the core dramatic principles of the poet: a poem is first written, and later staged. The performance of the Moscow Music Hall “How the Fourteenth Division Got to Heaven” (1932), having entered the history of the Soviet theatre as one of its highlights, played a key role in shaping the special phenomenon of performing arts — the theatre of satire and variety entertainment.
Site-Catchment Study of Kislovodsk Depression
Authors: Коробов Дмитрий , Korobov Dmitriy
Published: October 2019

The publication focuses on 2018 findings of a comprehensive soil-archaeological survey of the multi-temporal settlements catchment within Kislovodsk Depression. The most in-depth study was conducted in the vicinity of Podkumskoye 3 fortification (5th — 8th centuries AD), where 100 soil sections were laid along a regular network with 50 m step at different distances from the habitat zone. In the soil sections, archaeological material was recorded layer by layer, the description of soil profiles and sampling for chemical and microbiological tests were carried out. The samples were tested for active microbial biomass, urease activity, saprotrophs, magnetic susceptibility and phosphates.

This paper deals only with the findings of ceramics as a marker of farming practiced by ancient and medieval people living in this site. In total, about 2,380 fragments of pottery with a total weight of about 9 kg were discovered. A preliminary analysis of the spatial distribution of ceramics was carried out using the geostatistical module of ArcGIS software. It clearly showed different areas of farming in the Koban and Early Alanian areas. Now, the team is working on the analysis of the obtained material and soil samples for the detailed reconstruction of the site catchment in terms of farming.
21st International Scientific Conference “St. Petersburg and the Nordic Countries” (St. Petersburg, April 3–4, 2019)
Authors: Барышников Владимир , Baryshnikov Vladimir , Возгрин Валерий , Vozgrin Valeriy , Козлов Никита , Kozlov Nikita
Published: October 2019

The paper overviews the 21st International Scientific Conference “St. Petersburg and the Nordic Countries”. The spring meeting of Scandinavian researchers has become a traditional event and one of the most reputable conferences in the history of the Nordic countries. The participants of the conference, which embraced five sections, managed to discuss many issues faced by the historical science. The researchers announced their latest developments in the field of source study and historiography of Northern Europe, the socio-economic development of the Scandinavian countries, the political confrontation in the Baltic region and other major issues of the history of Northern Europe.
Calculation Model of Long-Term Economic Growth of Russia on the Basis of the Solow Model
Authors: Boyko A. A. , Kukartsev V. V.
Published: October 2019

В работе представлена имитационно-динамическая модель расчета долгосрочного экономического роста на основе неоклассической модели Р. Солоу. Модель разработана на основе метода системной динамики инструментальными средствами AnyLogic. В построенной модели расчеты проводились для двух вариантов долгосрочного развития экономики России, без учета и с учетом научно-технического прогресса. Модель расчета долгосрочного экономического роста использовалась в качестве инструмента для исследования, какой из вариантов развития выгоднее. Представлена структура интерфейса управления моделями расчета долгосрочного экономического роста по модели Солоу. Графически изображена диаграмма потоков и уровней расчета долгосрочного экономического роста. Также представлена панель программного управления моделью расчета долгосрочного экономического роста. Результаты расчета долгосрочного экономического роста без учета научно-технического прогресса изображены графически и представлены на рисунках. В результате экспериментов с вариантами было установлено, что вариант, учитывающий технический прогресс, является предпочтительным. Проведенное исследование позволяет сделать вывод, что разработанная имитационно-динамическая модель является достаточно универсальной и на ее основе можно проводить разнообразные исследования, касающиеся различных сторон долгосрочного развития экономических систем разного уровня.
Research Of Influence Of Reactive Jet On Dispersion Of Rocket Turns When Shooting From A Moving Carrier
Authors: Korolev S. A.
Published: October 2019

В работе представлена методика расчета поправок к аэродинамическим коэффициентам, учитывающих влияние струи реактивного двигателя впереди летящих ракет при залповых пусках с подвижного носителя. Положение ракеты относительно реактивной струи определяется на основе расчета траекторий движения ракет. Моделирование обтекания ракеты реактивной струей проводилось путем численного решения системы уравнений Навье – Стокса, осредненных по Фавру, с применением k–ε-модели турбулентности. На основе обработки результатов численного эксперимента для широкого диапазона изменения параметров (положение ракеты по длине и радиусу струи, скорость движения ракет, углы нутации ракет) построены аппроксимационные зависимости для поправок к аэродинамическим коэффициентам, учитывающих влияние реактивной струи.С использованием полученных зависимостей для аэродинамических коэффициентов в методике расчета траектории проведено исследование влияния реактивной струи на точность стрельбы с подвижного носителя при различных начальных условиях: интервал времени между пусками, начальное расстояние между осями ракет, начальное значение угла нутации второй ракеты. Определена область изменения параметров, где влиянием реактивной струи можно пренебречь. Рассмотрен пример моделирования нештатной ситуации срабатывания боеприпаса.
Solution of Problems of External Ballistic Design on the Basis of Mathematical and Computer Modeling
Authors: Korolev S. A. , Sufiyanov V. G.
Published: October 2019

Статья посвящена разработке математического и программного обеспечения решения задач внешней баллистики. Математическая модель траекторной задачи основана на системе уравнений движения снаряда, учитывающей вращение и колебания относительно центра масс. Параметрические зависимости для аэродинамических коэффициентов определяются с помощью численного моделирования внешнего обтекания снаряда. На основе математической модели внешней баллистики разработаны алгоритмы решения обратной задачи, имитационного моделирования рассеивания снарядов, стрельбы очередью с подвижного носителя.Программный комплекс решения задач внешней баллистики включает блок расчетных модулей, реализующих представленные математические модели и вычислительные алгоритмы, базу данных параметров вооружения и результатов моделирования, систему визуализации результатов вычислительного эксперимента.Представлены некоторые результаты решения задач внешней баллистики при проектировании и отработке ракетно-артиллерийского вооружения. Проведено сравнение результатов расчета траектории, полученных с использованием расчетной модели сопротивления и эмпирических законов сопротивления. Представлены результаты моделирования рассеивания снарядов и стрельбы из ракетно-артиллерийского вооружения с подвижного носителя. Результаты моделирования отображаются в системе трехмерной визуализации на виртуальной карте местности.
Н.С. Хрущёв и борьба с излишествами в советской архитектуре (1949–1954 годы)
Authors: Kuznetsov Sergey
Published: October 2019

В статье на основе архивных материалов показано, что градостроительная повестка Н.С. Хрущёва, ориентированная на «борьбу с излишествами» в советской архитектуре, сформиро­валась задолго до 1954 года. Фактически ещё в тридцатые годы он высказывался за экономию при строительстве в Москве. После возвращения на пост первого секретаря Московского комитета Коммунистической партии в декабре 1949 года Н.С. Хрущёв попытался изменить парадигму градостроительной политики: во время его деятельности в Москве был пересмо­трен амбициозный план реконструкции центра, разработанный при его предшественнике Г.М. Попове. Хрущёв поддержал ме­роприятия по типизации, стандартизации и индустриализации строительства; предложил реформу строительной отрасли Мо­сквы, снизил долю ведомственного строительства, которое вело к распылению усилий; перенёс фокус внимания с магистралей на окраинные кварталы. Целями его политики были экономия государственных ресурсов и развитие массового жилищного строительства. Можно предположить, что известное постанов­ление ЦК КПСС и СМ СССР от 4 ноября 1955 года № 1871 «Об устранении излишеств в проектировании и строительстве» в значительной степени опиралось на результаты деятельности Хрущёва в области градостроительства в Москве после Великой Отечественной войны.
О взаимосвязи государственной политики регионального развития,стратегического и территориального планирования и градостроительства в целях устойчивого развития Российской Федерации
Authors: Лысая Дарья , Sun Yimin , Zhang Chunyang
Published: October 2019

В потоке глобальных экономических, технологических, информационных перемен России необходимо быстро приспособиться к новым тенденциям. Бесценный ресурс - огромные просторы страны - нуждаются в программе развития, соот¬ветствующей современной задаче: при сохранении единства и безопасности страны вписаться в мировое экономическое пространство. Устойчивое развитие России зависит от эффективности государственной политики регионального развития и территориального планирования. Совершенствование пространственной организации может стать мощным ресурсом будущего развития страны. Целью статьи является анализ структуры реализации государственной политики регионального развития в системах стратегического и территориального планирования и градостроительстве. Реализация государственной политики регионального развития является комплексной задачей системы стратегического планирования РФ, которая внедряется на всех уровнях власти. В состав системы стратегического планирования интегрируется система территориального планирования. На федеральном уровне связующим звеном систем стратегического и территориального планирования является Стратегия пространственного развития РФ до 2025 года, которая внесёт вклад в формирование будущего облика России, государства, конкурентноспособного на мировом уровне.
Человек и архитектурное пространство: осмысление взаимосвязей в социальных науках и градостроительной практике
Authors: Мельникова Varvara
Published: October 2019

В статье представлены основные подходы к взаимосвя­зям человека и архитектурного пространства в современных социальных науках - и в градостроительных практиках. Вы­двинута теория о том, что подробное изучение концепций взаимосвязи человека и архитектурного пространства может подготовить основу для успешной реализации любого про­екта: от строительства новых зданий до внедрения новых подходов в области градостроительства.

В рамках доказа­тельной базы этого тезиса рассмотрены труды урбанистов, архитекторов и писателей, таких как: К. Линч, Дж. Джекобс, Р. Флорида. Приведены примеры ревитализации старых районов Барселоны и такие крупные архитектурные проекты как музей Гуггенхайма в Бильбао. Особое внимание уделено таким понятиям как «чувство места», «идентичность места» и «привязанность к месту».
Patogenia de las infecciones virales I
Authors: Collao Ximena , Faúndes Nicolás
Published: October 2019

La patogenia comprende una serie de eventos y procesos que se combinan para producir enfermedad. La patología está relacionada con las anormalidades resultantes de la reacción a la injuria. La relación virus-célula producida durante la infección viral en un huésped no corresponde necesariamente a la observada en el tejido ya que existen factores que determinan que un virus pueda o no infectar un huésped y que dicha infección se manifieste o no en enfermedad.
Autopsias realizadas por el Dr. Salvador Allende en el Hospital Carlos van Buren de Valparaíso, Chile.
Authors: Pérez Gaete Salomon , Rodríguez Badilla Valentina , Castillo Myriam , Cruz Choappa Rodrigo
Published: October 2019

Introducción: entre los años 1933 y 1937, el Dr. Salvador Allende trabajó con regularidad en el servicio de Anatomía Patológica del Hospital Carlos van Buren de Valparaíso (HCVB), realizando autopsias en los casos de muertes de causa médica. Materiales y método: se revisaron los libros del servicio de Anatomía Patológica del HCVB del año 1937 y fueron seleccionaron las autopsias realizadas por el Dr. Allende. Los libros y autopsias de los años 1933 a 1936 no pudieron ser encontrados. Los datos demográficos de los pacientes se traspasaron a una planilla Excel. Los resultados se expresaron en números y porcentajes. Resultados: el Dr. Allende realizó 54 autopsias durante un periodo de 5 meses, lo que correspondió al 12,6% de las realizadas ese año.  De los 54 pacientes, 48 (88,8%) correspondieron al sexo masculino, con un promedio de edad de 46 (9-97) años. La mayoría tenían nacionalidad chilena y estaban cesantes. El 53,7% de los casos falleció por una causa infecciosa y las más frecuentes fueron la neumonía y la tuberculosis. La concordancia entre los diagnósticos clínicos y de Anatomía Patológica fue de un 70,3%. Conclusiones: se encontró solo una parte de las autopsias realizadas por el Dr. Allende en el HCVB. La mayoría de los pacientes fallecidos fueron jóvenes del sexo masculino y cesantes. Las principales causas de muerte fueron la neumonía y la tuberculosis.
Revisión del género Boletus L. (Boletales, Basidiomycota) en Chile
Authors: Riquelme Cristian , Dibán María José , Salazar Vidal Viviana
Published: October 2019

El género Boletus cuenta con alrededor de 300 especies, las cuales se encuentran ampliamente distribuidas en el mundo, formando micorrizas con diversos árboles. En Chile se han documentado seis especies: Boletus loyo, B. loyita, B. chilensis, B. putidus, B. bresinskyanus y B. araucariae, asociadas exclusivamente a Nothofagus spp., siendo Boletus loyo actualmente clasificada en el género Butyriboletus. En esta revisión, se describen los caracteres macro y microscópicos junto con la distribución climática de las seis especies nativas presentes en nuestro país de acuerdo a la literatura. Además, se presenta una clave dicotómica basada en bibliografía relevante para ayudar a su determinación.
DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD DETERMINATION OF ZIDOVUDINE ENCAPSULATED IN PCL NANOPARTICLES
Authors: Ribeiro Souza Magalhães Milena Cristina , Portes Caldeira Alisson Samuel , De Sousa Rocha Almeida Hanna , Ligório Fialho Sílvia , Da Silva Cunha Junior Armando
Published: October 2019

A reversed-phase high-performance liquid chromatographic (HPLC) method was developed and validated for the determination of encapsulation efficiency of zidovudine in nanoparticules. The method was carried out in isocratic mode using 0.040M sodium acetate: methanol: acetonitrile: glacial acetic acid (880:100:20:2) as mobile phase, a C8 column at 25ºC and UV detection at 240 nm. The method was linear (r2 ˃ 0.99) over the range of 25.0-150.0 μg/mL, precise (RSD ˂ 5%), accurate (recovery = 100.5%), robust and selective. The validated HPLC-UV method can be successfully applied to determine the rate of zidovudine in nanoparticules.
UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS
Authors: Tassinari da Silva Andressa , Rossi Brabo Gabriela , Dias Marques Isadora , Bajerski Lisiane , Donadel Malesuik Marcelo , Soldateli Paim Clésio
Published: October 2019

Bilastine is a novel nonsedative H1-receptor antagonist, which may be used for the symptomatic treatment of chronic idiopathic urticaria (CU). This study describes the validation of an UV spectrophotometric method for quantitative determination of bilastine in tablets using 0.1 mol L-1 HCl as solvent. The method was specific, linear, precise, exact and robust at 210 nm, confirming that the method is fast and useful to the routine quality control of bilastine in tablets. The validate method was compared to liquid chromatography (HPLC), which was previously developed and validated to the same drug, and no significative difference between the methods using Student´s t test was found to bilastine quantitation.
VALIDATION OF A SIMPLES METHOD FOR SIMULTANEOUS DETERMINATION OF LIPOIC ACID AND RESVERATROL BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: Guerreiro Irene C K , Davies Samuel , Guterres Silvia , Berlitz Simone Jacobus
Published: October 2019

A high-performance liquid chromatography-ultraviolet (HPLC-UV) method was developed and validated for simultaneous determination of Resveratrol (RSV) and Lipoic Acid (LA). A C18 column was used with a mobile phase consisting of acetonitrile and 0.01M phosphoric acid (60:40). The detection wavelength was at 235 nm. The method was specific in the presence of pharmaceutical excipients widely used in solid dosage forms or lipid-core nanocapsules. The results demonstrated linearity between 5 and 50 µg/mL for RSV and 30 and 120 µg/mL for LA. The method presented precision and accuracy (RSD <5%). In addition, the developed method was considered robust. Therefore, the developed method can be applied successfully for simultaneous determination of RSV and LA in the proposed conditions, with a potential application to assay both drugs in several dosage forms.
DEVELOPMENT AND VALIDATION OF A SIMPLE AND FAST METHOD FOR SULFONAMIDES, TETRACYCLINES AND MACROLIDES IN HONEY USING LC-MS/MS
Authors: Ribeiro Cristina Belissimo , Martins Magda Targa , Jank Louise , Barreto Fabiano , Hoff Rodrigo Barcellos , Arsand Juliana Bazzan
Published: October 2019

Antibacterial are widely used in veterinary applications for diseases treatment and prophilatic purposes. Inadequate uses of these drugs can lead of undesirable residues in honey for consumption. In Brazil, the legal authorities set a maximum residue limit (MRL) for different compound in honey, ranging from 10 to 20 ng ml-1. The monitoring of antibacterials is a concern, since it constitutes a risk to human health and collaborates with the growth of resistant bacteria. Brazil has the National Residue Control Plan (NRCP) to ensure that the products traded are compliant with the safety and quality criteria required by consumers. The goal of this work was to develop and validate a method suitable to determine sulfonamides, tetracyclines and macrolides in honey, using liquid chromatography tandem mass spectrometry. The main objective was to develop an efficient technique, combining simplicity, speed and low cost, since the method will be employed in routine analysis. Recoveries between 36 to 139% were obtained. Good linearity (r2) above 0.95, considering three different days, for all drugs was achieved in concentrations ranging from 0 to 200% of the MRL. Intraday and inter-day precision with CV% (n=6) lower than 18%, in agreement with specifications were obtained in concentrations ranging from 0.5 to 1.5 MRL, except for erythromycin. Accuracy was between 97 to 108%. Limits of quantitation for macrolides were 2.5 ng g-1and for sulfonamides and tetracyclines were 5 ng g-1. Decision limit (CCα) was evaluated and the results obtained were between 12.9 to 28.1 ng g-1. The detection capability (CCβ) obtained was between 15.8 to 36.3 ng g-1. The proposed method demonstrated to be suitable for this intended purpose and will contribute to antibacterial honey monitoring.
GREEN ANALYTICAL METHOD FOR QUANTIFICATION OF SECNIDAZOLE IN TABLETS BY HPLC-UV
Authors: Lima Jéssica , Kogawa Ana , Salgado Hérida Regina Nunes
Published: October 2019

A simple, rapid, economic and green analytical method was validated for the determination of secnidazole in tablets. The aim was to contribute to the green analytical chemistry since it has low use of organic solvent and low production of toxic waste. For the HPLC-UV method, the mobile phase was a mixture of purified water + 0.7 % acetic acid and ethanol (78:22, v/v), ﬂow rate was 1.3 mL min-1 on column CN Phenomenex Luna (250 x 4.60 mm, 5 μm particle size), injection volume was 20 μL with UV detection at 318 nm and retention time of 4.26 minutes. The method was linear over the concentration range of 5-100 μg mL-1 (r = 0.9998) with limits of detection and quantitation of 0.533 e 1.615 μg mL-1, respectively. The precision of the method showed RSD less than 2 %. The accuracy determined by the average recoveries was 99.58 %. The secnidazole tablets were subjected to oxidation, acid, alkaline, neutral and photolysis degradation as stress conditions and the method was considered as indicative of stability. The method is adequate and safe to be a great alternative method in routine quality control analyzes for determination and quantification of secnidazole tablets.
DRY-POWDER OF CHITOSAN-COATED LIPID-CORE NANOCAPSULES CONTAINING DAPSONE: DEVELOPMENT, LASER DIFFRACTION CHARACTERIZATION AND ANALYTICAL QUANTIFICATION
Authors: Cé Rodrigo , Soledade Jornada Denise , Guilherme Barreto De Marchi João , Stanisçuaski Guterres Silvia , Raffin Pohlmann Adriana
Published: October 2019

Analytical techniques are critical for ensuring physical and chemical stability of a drug both for assessing the stability of drug molecules and for quantifying and identifying the drug content in products. We proposed the development of dry-powders of lipid-core nanocapsules containing dapsone and coated with chitosan, as well as, the analytical quantification of dapsone in dry-powders with 1% and 2% (m/v) of leucine by high-performance liquid chromatography (HPLC). Size is the most relevant physicochemical property of nanoparticulated drug delivery systems. In this context, our results demonstrated that during the powders redispersion in water, could be observed that the mean particle diameters (DAP-LNC-CS-L1 and DAP-LNC-CS-L2) decreased with redispersion times increase. The spray-drying of the lipid-core nanocapsule formulations showed yields ranging from 58 ± 1.0 % (DAP-LNC-CS-L1) to 61 ± 1.5 % (DAP-LNC-CS-L2) indicating an efficient drying process. In this context, the analytical quantifications of dapsone in the dry powders of nanocapsules by HPLC showed that the dapsone content ranged from 92 ± 1.4% (DAP-LNC-CS-L2) to 95 ± 0.8% (DAP-LNC-CS-L1). Can be concluded that spray-drying process of DAP-LNC-CS-L1 and DAP-LNC-CS-L2 formulations showed an efficient aqueous dispersion of nanocapsule powders and the analytical quantification of dapsone in spray-dryed powders were higher than 90%.
The role of opportunistic pathogens as etiological agents of intrauterine infections
Authors: Kosenchuk V. V. , Rybalkina T. N. , Boshyan R. E. , Karazhas N. V. , Kornienko M. N. , Veselovsky P. A. , Lysenkova M. Yu. , Savenkova M. S. , Ivanova M. Yu.
Published: October 2019

The study showed a high prevalence of markers of herpesvirus infections among mothers — from 71% to 98% of HSV, EBV and CMV infections and from 29% to 58% of HHV-6 infection. HSV remains the most common etiological agent of intrauterine infections among herpesviruses — markers of active infection caused by this virus were found in 28.3% samples. The difficulty of determining the source of infection in the absence of data in the early stages of pregnancy is presented on 4 out of 10 cases of active HHV-6 infection. Markers of active pneumocystic infection were detected only in mothers: in the group with children under the age of 21 days — in 21—27% of cases, with children aged 22 to 28 days — in 15—21%. In addition to non-specific multiple organ failure during intrauterine infections (26.3%), only one organ system was observed: hypoxic-hemorrhagic lesions of the central nervous system were diagnosed more often — 17%, as well as meningitis/encephalitis, or hepatitis, or pneumonia, or disorders of hematopoiesis, or rash. In 17.5% of children from the comparison group, i.e. without any clinical manifestations of intrauterine infections, markers of active herpes virus infections were detected.
Тhe prophylactic efficacy of a recombinant interferon alfa-2b drug in children with bronchial asthma
Authors: Zhakov Y. I. , Minina E. E. , Medvedeva L. V.
Published: October 2019

A prospective cohort study was conducted to assess the effect of a recombinant interferon alpha-2b prophylactic course on cyto-immunological parameters of induced sputum in children with mild asthma, the main trigger of exacerbation of which was respiratory viral infections.

We examined 40 children aged 1 to 7 years with (mean age — 4.8 ± 0.2 years), half of whom received a course of recombinant interferon alpha-2b. The authors detected respiratory viruses in scrapings from throat and nose (PCR method) and evaluated the different cell counts, also the levels of interleukin-10, tumor necrosis factor alpha, interferon alpha and immunoglobulin E on the 1st and 30th day of the study (ELISA method) were determined in sputum.

The number of asthma exacerbations, triggered by respiratory viral infection, decreased in 4.5 times against. In children who received recombinant interferon alpha-2b the count of sputum eosinophils and the number of children with sputum eosinophilia (≥3 %) reduced. After two months the level of nasal eosinophils was 30% lower than the start level. The level of IgE in induced sputum decreased by 35%, but the level of IL-10 was increased by 1.5 times. 75% of parents whose children received recombinant interferon alpha-2b, note positive effect of this drug.

There were no adverse events to receive the drug in any case. Thus, the use of recombinant interferon alpha-2b in children with virus-induced asthma to reduce episodes of exacerbations associated with acute respiratory diseases can be recommended.
Clinical and epidemiological features of the Measles in children of the Astrakhan region
Authors: Kharchenko G. A. , Kimirilova O. G.
Published: October 2019

According to the Rospotrebnadzor of the Russian Federation for the first quarter of 2019 were registered 872 cases of measles, which indicates a tense epidemic situation for this pathology.

Objective: to establish clinical and epidemiological features of measles in children depending on age in the Astrakhan region for the period from January 2013 to June 2019.

Research methods: the analysis of 370 cases of measles in children aged 3 months to 17 years, confirmed by enzyme immunoassay (ELISA).

The results of the study: in the age structure of the incidence of measles in the Astrakhan region prevail unvaccinated children aged 2—3 years, and less than 1 year, not subject to vaccination against measles. The main reasons for the lack of vaccinations in children with measles are: medical taps. The incidence of vaccinated children against measles can be a consequence of violations in the organization of vaccination work. The causes of the presence of measles foci with the spread of infection are nosocomial outbreaks, measles drifts in organized groups, as a result of late detection and isolation of patients. Measles in children of different age groups, both vaccinated and unvaccinated proceeded typically with a predominance of moderate forms. The symptom of Filatov-Koplik remains the main sign of the diagnosis of measles in the catarrhal period of the disease, the gradual appearance of a spotty-papular rash in combination with catarrhal syndrome — in the period of rash, and pigmentation is a retrospective sign of the survive infection.
To the issue of differential diagnosis of listeriosis
Authors: Kladova O. V. , Andzhel A. E. , Kompaniets Yu. V. , Grishkevich N. L.
Published: October 2019

A clinical example shows the erroneous diagnosis of listeriosis in a 15-year-old child hospitalized in the infectious department. The child was admitted with severe symptoms of intoxication, febrile fever, difficulty in nasal breathing, hyperemia of the mucous membranes of the oropharynx, tonsillitis, cervical lymphadenitis, facial tissue pasteness with swelling of the eyelid and conjunctivitis of the left eye, hepatosplenomegaly. A laboratory examination revealed pronounced leukocytosis up to 24 thousand, lymphocytosis, atypical mononuclear cells up to 9%, IgM and IgG to EBV capsid protein, IgM to CMV, IgM and IgG to listeria. But with a repeated double study of IgM and IgG to Listeria were not detected. The initial positive result was possibly due to the presence of cross-reacting antibodies in EBV mononucleosis. The final diagnosis was made: Infectious mononucleosis of mixed (EBV, CMV) etiology. Chronic polypous rhinosinusitis, exacerbation. Reactive edema of the eyelids against the background of inflammation of the sinuses.

Given the variety of clinical forms of listeriosis and their similarity with the manifestations of other infections, for the full diagnosis of listeriosis infection, it is advisable to evaluate the epidemiological and medical history data, as well as use an extended spectrum of laboratory confirmation of the diagnosis.
The use of modal analysis to examine the lattice structure
Authors: Zoltowski M. , Jeleniewicz K.
Published: October 2019

Steel structures are subject to large dynamic loads clearly reflected by generated vibration processes. The vibrations may affect state of serviceability of structures by lowering comfort of persons working there as well as possible reaching the level hazardous to safety of the structures. The effect of vibrations to structure is mainly manifested by additional stresses in a given cross-section, which are summed up with those resulting from static loads. The dynamic loads may cause damaging effects in buildings of various structural types or even lead to their destruction. Judging the necessity of improving the quality assessment methods of building structures for purposes of estimation of their state as well as safety factors for lattice structures, the author of this work undertook an attempt to investigate destruction process of selected object by using the modal analysis method.
The thermomodernization of a single family house located in the Świętokrzyskie Mountains - a case study
Authors: Pawlak U. , Pawlak M.
Published: October 2019

The paper presents the energy performance of a single-family house located in Domaszowice, the Kielce poviat. The analyzed object has been put into use in 2010 year. Due to the devices using non-renewable energy sources, installed in the building for the needs of hot tap water and central heating, for servicing, which human presence is necessary, two thermomodernizations were performed. The purpose of the calculations was to indicate the financial benefi ts, i.e. to reduce the costs of maintaining the home and to provide its residents with proper comfort of use of the building, bearing in mind also the health aspect. Changes have been proposed to reduce the demand for non-renewable primary energy of EP using renewable energy sources. As a result, the energy-efficient building that meets WT 2017 was obtained. The Certo 2015 program was used in the analysis.