bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing Ethical Sensitivity Development in Undergraduate Engineering Students
Authors: Thoo Amanda , Strong David
Published: October 2024

An essential part of upholding high ethical standards in engineering involves being able to detect and identify ethical issues. This refers to one’s Ethical Sensitivity (ES), which is often overlooked in Engineering Ethics Education (EEE). This then leads to the question, are students’ ES skills being developed over the course of their undergraduate career? There is currently very little research on ES assessment in engineering students. Additionally, current ES assessment tools are either not designed to specifically assess ES, are not designed for engineering, and/or cue the participant in some way to the ethical dilemmas, which could misrepresent the participant’s actual ES abilities. The focus of this paper is to outline the process used to develop the research instrument and to discuss some key findings after the first round of qualitative data analysis. The next steps for this research and some early limitations on the study will also be discussed.
Data Analytics in Engineering Education: Lessons Learned from a Canadian Engineering School
Authors: Chan Ariel , Noval Graeme , Pitchika Ayushi , Bolarin Oluwadamilola , Liu Qin
Published: October 2024

We extended our earlier student data analytics work [1] to further analysis of 10 years of 11,000+ engineering undergraduates’ academic records in the Faculty of Applied Science and Engineering at the University of Toronto to uncover underlying factors impacting students’ academic performance upon graduation. We explored the potential of using supervised and non-supervised machine learning algorithms to select the key features that strongly correlate with the identified students’ academic performance. K-means clustering method was used to study math competency on academic performance and the findings indicate factors other than math can significantly influence student performance. We also applied Association Rule to study life-long learning attributes based on the completion of minors and certificates. From the results, we noticed that technical minors choices correlated strongly with specific core engineering programs and there are also marked differences in terms of gender, legal status and Professional Engineering Year/COOP completion. Various visualization graphical methods including Heatmap, Pie Char, Sanky Diagrams were applied to aid the analysis. The power of data analysis enables a better understanding of our engineering students’ experiences and informs evidence-based decision-making in our school.
Data Sustainability in Manufacturing Engineering Education
Authors: Sielmann Christoph , Bakhshi Nima , Hunter Carrie
Published: October 2024

The value of data in manufacturing is immense, with the proper curation of data resources becoming a necessary skill closely aligned with principles of sustainability, where data infrastructure must be designed and deployed with longevity in mind to realize ongoing growth in manufacturing and related industries. This article summarizes an exploratory investigation into instructor perceptions of data-related learning outcomes through curricular analysis in a manufacturing engineering program. Data sustainability is considered in the context of data lakes, where data are stored enriched with metadata with longevity in mind and made available to all who may need them. Conversely, data swamps, where data are difficult to place in context or to retrieve by those who would benefit from their use, result from unsustainable data practises. Appropriate data learning outcomes were developed through literature review and stakeholder engagement. A qualitative study then asked instructors in a manufacturing engineering program to map course learning outcomes against data learning outcomes at three levels of development. Follow up interviews with instructors provided insight into how data themes are perceived at high levels in the program. Initial surveying indicated that intended course outcomes aligned appropriately with the data outcomes in an increasingly complex way over time, yet the interviews highlighted some discrepancies between survey results and perspectives later revealed by course instructors. Opportunities to emphasize sustainability and long-term utility of data archives (data lakes) are discussed, stressing the need for further work.
Development of a scalable, immersive, multiplayer game for teaching engineering courses
Authors: Islam Tahzinul , Wei Moshi , Amirfazli Alidad
Published: October 2024

A scalable and immersive game was developed to serve as a monthly concept review game for theory-heavy engineering courses (such as fluid dynamics or heat transfer). It was designed such that in-game items and content may be dynamically replaced easily with an Excel data table, without the need for further programming. It is expected that course instructors may use such a tool by simply updating an Excel data table to rapidly tailor the game for any course. Even room/zone designs may be parametrized using a data table. Given the automation level of such a tool, its scalability and adaptability, the results of this work demonstrate the an innovative tool for educators to use for rapid construction of fun learning environments for engineering students in fun, game worlds. Future multiplayer game development can aid with collaborative learning to an even higher degree.
Academic integrity: A restorative justice approach in first year engineering
Authors: Jamieson Marnie , Mertiny Pierre
Published: October 2024

Academic integrity is a cornerstone of post-secondary education. Academic integrity violations disrupt the soundness of the assessment process, which is exacerbated in professional programs like engineering where accreditation hinges on the measurement of student proficiencies and graduate attributes. Engineering programs are typically challenging with demanding schedules and higher than typical workloads. Freshmen often face this challenge with deficient time management skills, which is coupled with increasing student mental health and wellness concerns. Combined with pressure to perform, these systemic issues can create circumstances in which students rationalize opportunities that constitute potential code of conduct violations, especially in group situations. The academic misconduct investigation process can be resource intensive, time intensive and stressful for students, instructors, and administrators. A restorative justice model was implemented as an alternative path to manage a large number of cases in first year engineering. The objective of using this approach was to educate students, emphasize the connection between academic integrity and engineering ethics and prevent further occurrences. This paper describes the development and use of this collaborative approach for first year.
The Flood Resilience Challenge serious role-playing game as an online education and engagement tool in a large engineering class
Authors: Bogdan Eva , Ibrahim Nadine , Murdock Heather
Published: October 2024

Complex socio-environmental problems, such as flooding, cannot be adequately addressed through technical engineering solutions alone. Limited curricular opportunities exist for engineering students to understand and gain skills towards working collaboratively to address such problems. To enhance engineering students’ learning on flooding and engagement in the classroom, they participated in the Flood Resilience Challenge (FRC) serious role-playing game. This research investigates two main hypotheses. First, the FRC game is effective in helping students’ meet their learning objectives: (a) Increase flood literacy; (b) Better understand differing flood stakeholders’ views and power; and (c) Make connections between the game and real-life. Second, the FRC role-playing game will increase students’ engagement in the classroom through experiential learning. These hypotheses were tested using pre-game and post-game questionnaires, and a debrief. The findings suggest that the FRC game is an effective teaching-learning tool for enhancing engineering students’ understanding of the socio-environmental complexities of flooding issues. Students also reported that the FRC game, as an experiential learning tool, is more effective than traditional approaches to engineering education, such as lectures and readings. The research findings on the FRC game have relevance for a range of disciplines focusing on complex socio-environmental problems and as a tool to provide engaging online educational activities.
Sociotechnical Thinking as a Contextualizing, Transcending, and Cross-Connecting Concept for Engineering Learning
Authors: Aleong Richard , Alkabbani Tarek
Published: October 2024

The complexities of contemporary engineering problems and solutions require deep attention to multiple social and technical aspects pertaining to the situation. Sociotechnical thinking in engineering offers a way to navigate these social and technical complexities that inform the way we inquire and design. While sociotechnical thinking as it relates to engineering education has been explored in various ways, sociotechnical thinking remains an abstract concept with multiple meanings and interpretations. Educators and researchers must think critically about dominant conceptualizations to appreciate how these meanings inform teaching, learning, and practice. In this paper, we describe sociotechnical thinking as a contextualizing, transcending, and cross-connecting concept for engineering learning. First, we present three assumptions that may be limiting current approaches to sociotechnical thinking. Then, we illustrate three different shifts in framing sociotechnical thinking to contribute to an integrated understanding of sociotechnical thinking as it relates to curriculum and pedagogical design. With these shifts, we aim to add meaning and richness that expands pedagogical opportunities for sociotechnical thinking in engineering curriculum, learning and practice.
Supporting Graduate Attributes Through Effective Use Of Interactive Digital Learning Tools
Authors: Marasco Emily , Filali Kenza , Afifi Jana , Ghasemian-Roudsari Saina
Published: October 2024

In the digital transformation of engineering curricula, interactive digital learning technologies are now essential for delivery of course material and to provide engaging learning opportunities. However, given the immense inventory of available tools, it may be difficult for educators and students to select the best tool for their intended learning outcomes and goals. This study examines and organizes a range of interactive educational technologies into a preliminary framework. Considerations for digital literacy and diversity issues are presented, as well as recommendations for differentiating between tools. Future stages of the study are described as further work is done to optimize effective use of interactive digital learning tools in Canadian engineering education.
Taking Project Planning Seriously by Removing Project Deliverable Due Dates: First Attempt
Authors: Dumond Patrick , Foster Jason
Published: October 2024

Undergraduate design courses often include project management. However, the traditional structure of such courses, as codified in due dates, removes much of the responsibility for project management from students. To increase responsibility towards project planning, this paper explores the impacts of allowing student teams to set their own project deliverable deadlines. In a second-year product development course, students were provided with external client-based milestones. Groups were then tasked with developing and documenting their own due dates in a project plan, making it available to the teaching team, and then being held accountable for their project work schedule. Results showed that students perceived this new approach as being positive when compared to fixed due dates. Students also felt more responsible for their project plan. However, only organized students and teams appeared to benefit from this additional flexibility, while disorganized teams suffered from a higher amount of procrastination and greater team conflict.
Assessment of the level of awareness of retinopathy due to hypertension among Hail population
Authors: Almasaud Jluwi , Syed Abrar , Alshammari Bader , Alamer Solaiman , Alharbi Talal , Almozaini Khaled , Alzabni Sami
Published: October 2024

Objective: This study aimed to determine the awareness level of the Hail population about retinopathy caused by uncontrolled hypertension.
Methods: Between October and December 2023, a cross-sectional descriptive study was carried out in the Hail region of Saudi Arabia using an online structured questionnaire. Using social media sites, the final questionnaire was posted online until no more responses could be included. The first component contained information about demographics, including work statistics, age, gender, and education. Subsequent questions concerning public knowledge of hypertensive retinopathy (HR) were asked in the second component.
Results: The study questionnaire was completed by 441 individuals in total. The age range of the study participants was 18 to over 40 years old, with a mean age of 30.1 ± 11.8 years. Of the participants in the study, 246 (55.8%) were men. The majority of participants (76%; 355) showed low awareness of HR, while 106 participants (24%) had an overall good awareness level.
Conclusion: Public awareness about HR in the Hail region was low, with awareness levels mainly among high-income and student participants.
"Antes de América. Fuentes originarias en la cultura moderna". Fundación Juan March, Madrid,del 6 de octubre de 2023 al 10 de marzo de 2024
Authors: Guijarro Galindo Pelayo
Published: October 2024

Review. "Antes de América. Fuentes originarias en la cultura moderna". Fundación Juan March, Madrid,del 6 de octubre de 2023 al 10 de marzo de 2024
Розробка антикризової стратегії діяльності компаній готельного бізнесу в умовах воєнного стану
Authors:   Національний університет «Чернігівська політехніка», Холодницька Алла
Published: October 2024

Стаття присвячена вивченню впливу сучасних викликів на показники діяльності підприємств готельного бізнесу, виявленню чинників, що стримують їхній розвиток та ключових аспекти та сценарії розробки антикризової стратегії, зорієнтованої на особливості провадження діяльності в умовах воєнного стану. Виокремлені такі компоненти антикризової стратегії, як безпека перебування відвідувачів, багатофункціональний персонал, перепрофілювання діяльності, впровадження інноваційних диджитал-технологій, оновлення сайту. зміна маркетингової, перегляд постачальників, зміна кадрової стратегії, підвищення соціальної відповідальності бізнесу, впровадження екологічних інновацій, запровадження мобільних послуг, продумане розселення відвідувачів, яке дасть можливість економити на комунальних послугах, а також дасть змогу оптимізувати час на обслуговування номерів.
Нова модель економіки України: пошук оптимального вектора після-воєнного розвитку
Authors:   Національний університет «Чернігівська політехніка», Мініна Окcана , Дерій Жанна ,   Національний університет «Чернігівська політехніка», Шадура-Никипорець Наталія ,   Національний університет «Чернігівська політехніка»
Published: October 2024

У статті розглянуто особливості розвитку економіки України за останнє десятиліття, проаналізовано тенденції, що склалися в довоєнний період, а також зміни, які відбулися через агресивну війну проти нашої держави, та їх можливі наслідки для подальшого розвитку. З’ясовано, що більшість виробництв вітчизняної економіки належать до третього або четвертого технологічних укладів, на п’ятий – приходиться близько 4 %, виробництва шостого укладу в нашій країні відсутні. Як оптимальний вектор післявоєнного розвитку економіки України запропоновано перехід від аграрної сировинної моделі до сучасної високотехнологічної, заснованої на виробництві продукції глибокого перероблення, розвитку ВПК з виходом на міжнародний ринок озброєнь із новітніми розробками, нарощування інноваційно-інтелектуального потенціалу країни.
Напрями трансформації маркетингових стратегій підприємств в умовах цифровізації
Authors:   Національний університет «Чернігівська політехніка», Олифіренко Юлія , Олифіренко Іван ,   Національний університет «Чернігівська політехніка», Біланенко Олександр ,   Національний університет «Чернігівська політехніка»
Published: October 2024

У статті розглянуто сучасні напрями розвитку цифрових технологій. Визначено способи застосування штучного інтелекту, доповненої та віртуальної реальності, аналітичних та криптотехнологій у маркетинговій діяльності та маркетингових стратегіях підприємств. Проаналізовано напрями використання технологій штучного інтелекту в маркетинговій діяльності. Систематизовано та наведено ключові характеристики основних цифрових трендів для подальшого практичного їх застосування. Зроблено висновок щодо необхідності комплексного підходу при використанні маркетингових стратегій, залежно від особливостей та характеристик підприємства, сфери його діяльності та цільової аудиторії.
Paradigma Pedagogi Reflektif Terintegrasi Flipped Classroom pada Materi Majapahit Mempersatukan Nusantara Menggunakan Media Pembelajaran Peta Timbul
Authors: Printina Brigida Intan , Kusmayadi Yadi , Nurholis Egi
Published: October 2024

Paradigma Pedagogi Reflektif terintegrasi Flipped Classroom pada materi Majapahit mempersatukan nusantara merupakan implementasi pembelajaran yang dilakukan pada kelas Media Pembelajaran Sejarah menggunakan sarana peta timbul. Tujuan penelitian yang pertama menguraikan pengalaman pembelajaran dengan menggunakan Paradigma Pedagogi Reflektif terintegrasi Flipped Classroom menggunakan media pembelajaran peta timbul, yang kedua ialah menganalisis hasil pembelajaran dengan menggunakan Paradigma Pedagogi Reflektif terintegrasi Flipped classroom menggunakan media pembelajaran peta timbul. Metode penulisan menggunakan penelitian kualitatif, dengan langkah pengumpulan data, reduksi data, analisis data, dan penarikan kesimpulan.  Subjek penelitian ini ialah mahasiswa Pendidikan Sejarah Universitas Sanata Dharma angkatan 2022. Hasil penelitian menunjukkan bahwa mahasiswa dapat berdinamika dan menjawab hasil penugasan berdasarkan 3 nilai keutamaan dalam PPR yaitu  nilai Competence atau penggalian konteks didapatkan hasil rata-rata mahasiswa mendapatkan 87% tingkat pemahaman dalam penggalian konteks pemahaman materi,  Pada nilai Compassion penggalian pengalaman, ada sekitar 86% pengalaman yang didapat untuk memaknai dinamika pengerjaan proyek dan sebagian besar memahami bahwa pengerjaan proyek peta timbul memliki banyak tantangan. Mahasiswa mendapatkan nilai Conscience dengan cara merefleksikan proses pengalaman dan banyak yang merasa mendapatkan wawasan dan pemaknaan dari pengerjaan media pembelajaran peta timbul, karena ada sekitar 88% mahasiswa yang mampu menggali nilai ketelitian, kesabaran, kreativitas serta tanggungjawab. Tindak lanjut dari hasil pembelajaran bahwa ada 21 mahasiswa yang akan menggunakan media yang sama dengan alasan kebermaknaan dalam dinamika kelompok  dalam pengerjaannya, dan menambah kemampuan metakognitif untuk menemukan relevansi pembelajaran sejarah. Sedangkan ada 4 mahasiswa yang tidak menggungakan karena memakan waktu, tenaga dan biaya.
Dampak Perang Bubat Terhadap Identitas Dan Kebudayaan Masyarakat Sunda
Authors: Sondarika Wulan , Ratih Dewi , Herdianto Heri
Published: October 2024

Penelitian ini berupaya mengkaji lebih lanjut bagaimana peristiwa Perang Bubat berdampak terhadap identitas dan kebudayaan masyarakat Sunda dari masa ke masa. Fokus kajian ini adalah pada bagaimana masyarakat Sunda menginternalisasi peristiwa tersebut dan menjadikannya bagian penting dari narasi budaya dan sejarah mereka. Penelitian ini bertujuan untuk memahami dinamika perubahan identitas masyarakat Sunda pasca-Perang Bubat, dan bagaimana peristiwa ini terus mempengaruhi pandangan mereka terhadap sejarah dan kebudayaan hingga era kontemporer. Metode dalam penelitian ini yaitu metode kulitatif dengan pendekatan historis dengan langkah penelitian; identifikasi masalah, pengumpulan data, kritik Sumber, analisis data, interpretasi dan historiografi. Hasil penelitian dampak Perang Bubat terhadap identitas dan kebudayaan masyarakat Sunda menunjukkan bahwa peristiwa ini tidak hanya menjadi bagian dari sejarah, tetapi juga membentuk persepsi dan sikap budaya yang bertahan lama. Perang Bubat menguatkan identitas budaya Sunda yang berpusat pada nilai-nilai kehormatan, kemandirian, dan sikap perlawanan terhadap dominasi eksternal. Meskipun sebagian dari dampak ini mulai terkikis oleh perubahan zaman, trauma kolektif yang ditinggalkan Perang Bubat masih mempengaruhi cara pandang masyarakat Sunda dalam hubungan antar-etnis hingga saat ini.
Potensi Sintren Sebagai Sumber Nilai dan Spiritual Masyarakat Petani Patimuan
Authors: Sudarto Sudarto , Nurholis Egi , Brata Yat Rospia
Published: October 2024

Sintren sebagai seni pertunjukan tradisional warisan budaya masyarakat petani, muncul sebagai ekspresi budaya yang signifikan dalam masyarakat petani Patimuan. Artikel ini mengeksplorasi potensi kesenian Sintren sebagai sumber nilai dan spiritualitas, dengan menekankan perannya dalam identitas masyarakat, kohesi sosial, dan pengayaan spiritual. Fokus utamanya pada nilai spiritual dalam sintren, nilai budaya serta perubahan dan tantangan di era globalisasi yang makin menggerus seni tradisional tersebut. Melalui analisis kualitatif dan keterlibatan masyarakat, studi ini menyoroti bagaimana kesenian Sintren yang tidak hanya sebagai upaya melestarikan warisan budaya tetapi juga menumbuhkan rasa memiliki dan tujuan tertentu di antara para petani. Berdasarkan penggalian potensinya didapatkan hasil bahwa Sintren sebagai sumber nilai dan spiritualitas masyarakat petani Patimuan, sekaligus sebagai media mentransmisikan cerita-cerita dan ajaran spiritual dari generasi ke generasi. Sebagai upaya mendidik masyarakat tentang pentingnya hidup selaras dengan norma-norma budaya dan agama.
Pharmacological possibilities of prolongation of atopic dermatitis remissions
Authors: Kochergin Nikolay G.
Published: October 2024

Atopic dermatitis (AD) is a common chronic recurrent immune-dependent pruritic dermatosis with a typical clinical picture and a damaging effect on the patient’s quality of life. The mechanism of symptom development includes genetic predisposition, defect in the barrier function of the skin and innate and adaptive immunity, and exposure to environmental triggers, infectious agents, allergens and mechanisms of comorbidities. The chronic nature of the dermatosis, the sharply reduced quality of life of patients with AD and poor adherence of patients to treatment create difficulties on the way to effective therapy of patients. These difficulties can be overcome by the proactive use of tacrolimus ointment (Protopic®) in the external therapy of patients with AD, which, after steroid suppression of the acute phase of exacerbation, applied twice a week, can significantly increase the duration of the achieved remission, improve the quality of life of patients and increase their adherence to treatment. The given brief analysis of the literature data and the results of our own observations confirm the high efficacy of the proactive use of Protopic® ointment in prolonging the remissions of atopic dermatitis.
ПРОФЕССИОНАЛЬНОЕ ВЫГОРАНИЕ В ЗАВИСИМОСТИ ОТ ТИПА ПЕРФЕКЦИОНИЗМА
Authors: С.М. Суботялова , М.А. Суботялов
Published: October 2024

Статья посвящена исследованию взаимосвязи типа перфекционизма (нормального и патологического) сотрудников с уровнем выраженности их профессионального выгорания. В качестве методов исследования были использованы «Опросник выгорания Маслач» (Maslach Burnout Inventory, MBI), в российской адаптации, предложенной авторами Н. Е. Водопьяновой, Е. С. Старченковой (2001); Е. И. Лозинской (2007)) и «Дифференциальный тест перфекционизма» А.А. Золотаревой (2013). По результатам проведенного исследования была установлена связь между уровнем эмоционального выгорания исследуемых сотрудников и преобладающей направленностью их перфекционизма. Сотрудники, в личности которых преобладает нормальный перфекционизм, характеризуются меньшей подверженностью эмоциональному выгоранию в профессиональной сфере, а также более адекватной оценкой своих достижений. Сотрудники, у которых превалирует патологический перфекционизм, в большей степени подвержены выгоранию, а также имеют тенденцию к занижению своих достижений. Данное исследование вносит вклад в изучение профессионального выгорания, расширяя, таким образом, эмпирическое изучение феномена, и дает базу для дальнейших исследований.

The article is devoted to the study of the relationship between the type of perfectionism (normal and pathological) of employees and the severity of their professional burnout. The “Maslach Burnout Inventory Questionnaire” (MBI) was used as research methods, in the Russian adaptation proposed by the authors N. E. Vodopyanova, E. S. Starchenkova (2001); E. I. Lozinskaya (2007)) and “Differential Perfectionism Tes” by A.A. Zolotareva (2013). According to the results of the study, a connection was established between the level of emotional burnout of the studied employees and the prevailing orientation of their perfectionism. Employees whose personality is dominated by normal perfectionism are characterized by less exposure to emotional burnout in the professional field, as well as a more adequate assessment of their achievements. Employees whose pathological perfectionism prevails are more prone to burnout, and tend to underestimate their achievements. This study contributes to the study of professional burnout, thus expanding the empirical study of the phenomenon, and provides a basis for further research.
К ВОПРОСУ О РЕЗУЛЬТАТИВНОСТИ МОДЕЛИ РАЗВИТИЯ ВНИМАНИЯ ВОДИТЕЛЕЙ ПАССАЖИРСКОГО АВТОТРАНСПОРТА В НЕРАВНОВЕСНЫХ ПСИХИЧЕСКИХ СОСТОЯНИЯХ
Authors: Ю. Воронцова
Published: October 2024

В статье представлены результаты экспериментального исследования, посвященные подтверждению результативности модели развития устойчивого внимания профессиональных водителей с особым сочетанием равновесных и неравновесных психических состояний. В исследовании применялись инструментальные и бланковые методики, направленные на диагностику и тренировку внимания и психических состояний. В исследовании участвовало 306 профессиональных водителей мужчин в возрасте 21-49 лет со стажем 3-31 года, постоянно осуществляющих перевозки пассажиров, среди которых было отобрано 60 водителей (соответствующих стеническому типу) в равной мере разделенных на экспериментальную и контрольную группы. В экспериментальной группе проводилась обучающая тренинговая программа длительностью в 2 месяца, включающая ряд упражнений на развитие навыков саморегуляции с целью перевода психического состояния из неравновесного в равновесное, а также непосредственную тренировку внимания. Модель развития устойчивого внимания подтвердила свою результативность на профессиональных водителях пассажирского автотранспорта.

The article presents the results of the experimental study devoted to confirming the effectiveness of the model of development of sustained attention of professional drivers with a special combination of equilibrium and non-equilibrium mental states. The study used instrumental and form methods aimed at diagnosing and training attention and mental states. The study involved 306 professional male drivers aged 21-49 years with the experience of 3-31 years, constantly carrying out passenger transportation, among which 60 drivers (corresponding to the stenic type) were selected and equally divided into experimental and control groups. In the experimental group a training program of 2 months duration was conducted, including a number of exercises for the development of self-regulation skills in order to transfer the mental state from disequilibrium to equilibrium, as well as direct training of attention. The model of development of sustained attention has confirmed its effectiveness on professional drivers of passenger motor transport.
НАЦИОНАЛЬНЫЕ МИФОКОДЫ ОБОРОТНИЧЕСКОГО БЫТИЯ В РУССКОЙ И УЗБЕКСКОЙ ПРОЗЕ
Authors: Г.Т. Гарипова
Published: October 2024

В статье рассматриваются художественные оборотнические модели бытия в русской и узбекской литературах второй половины ХХ века, выявляются национальные бестиарные мифокоды, связанные с русскими и восточными религиозно-философскими системами, анализируются проблемы символизации оборотнических мирообразов, построенных по принципу «превращенной формы», идентифицируются смысловые аспекты семантики «возможных миров». Аналитический акцент ставится на попытке идентифицировать специфику мифологической образности при создании бестиарного амбивалентного героя, в котором реализуется принцип комбинаторного сочетания уровня “discordia concors” (гармоничный разлад) и “concordia discors” (несогласованная гармония). К анализу привлекаются произведения писателей русской литературы - роман-сказка А. Кима «Белка», романы Д. Липскерова «Последний сон разума» и В. Пелевина «Священная книга оборотня»; узбекской литературы - роман Т. Пулатова «Черепаха Тарази».

Russian Russian and Uzbek literatures of the second half of the twentieth century are considered in the article, national bestial mythocodes associated with Russian and Eastern religious and philosophical systems are identified, the problems of symbolization of werewolf world images built on the principle of “transformed form” are analyzed, semantic aspects of the semantics of “possible worlds” are identified. The analytical emphasis is placed on an attempt to identify the specifics of mythological imagery when creating a bestial ambivalent hero, in which the principle of a combinatorial combination of the level “discordia concors” (harmonious discord) and “concordia discors” (uncoordinated harmony) is implemented. The analysis involves the works of writers of Russian literature - the fairy tale novel by A. Kim “Squirrel”, the novels by D. Lipskerov “The Last Dream of the Mind” and V. Pelevin “The Sacred Book of the Werewolf”; Uzbek literature - the novel by T. Pulatov “The Turtle Tarazi”.
В. ХЛЕБНИКОВ, А. КРУЧЕНЫХ, И. ЗДАНЕВИЧ: КОНЦЕПЦИЯ ВРЕМЕНИ В РУССКОЙ ФУТУРИСТИЧЕСКОЙ ДРАМЕ И ОПЕРЕ
Authors: А.В. Гик
Published: October 2024

В начале ХХ века русский театр вступил в эпоху художественных экспериментов. Авангардные сценические решения стали следствием теоретических разработок в том числе футуристов. Русские футуристы изобретательно использовали идею изменения хода времени в своих произведениях. Свобода от рамок классического ньютоновского мировоззрения позволила ввести в сюжет драмы элементы «мобильного» хронотопа. Такого рода примеры мы находим в следующих произведениях начала ХХ века: представление «Царь Максемьян и ево непокорный сын Адольфа» (постановщик Бонч-Томашевский, 1911); пьеса «Мирсконца» Велимира Хлебникова (1912); опера «Победа над солнцем» Алексея Крученых (1913); пьеса «Ошибка смерти» Велимира Хлебникова (1915); драма «Лидантю фарам» Ильи Зданевича (1923). В работе доказывается, что композиция и сюжет футуристического текста опираются на традиционные литературные и народно-фольклорные структуры. Новизна и «футуризм» образуются за счет языковых новшеств (например, неологизм «Мирсконца»; заумный язык драмы Ильязда), а также нетривиального выстраивания сюжетной линии, где персонажи драм сами путешествуют по времени или у них появляются специальные герои-проводники.

At the beginning of the twentieth century, the Russian theater entered the era of artistic experiments. Avant-garde stage solutions were the result of theoretical developments, including those of the futurists. Russian futurists ingeniously used the idea of changing the course of time in their works. Freedom from the framework of the classical Newtonian worldview made it possible to introduce elements of a “mobile” chronotope into the plot of the drama. The object of our study was futuristic works: the performance “Tsar Maksimyan and Evo’s Recalcitrant Son Adolf” (directed by Bonch-Tomashevsky, 1911); the play “Mirskonza” by Velimir Khlebnikov (1912); opera “Victory over the Sun” by Alexei Kruchenykh (1913); the play “Mistake of Death” by Velimir Khlebnikov (1915); drama “Lidantyu faram” by Ilya Zdanevich (1923). The paper proves that the composition and plot of the text are based on traditional literary and folklore structures. Novelty and “futurism” are formed due to linguistic innovations (for example, the neologism of “Mirskonza”; the zaum language of Ilyazd’s drama), as well as the non-trivial construction of the storyline, where the heroes of dramas themselves travel through time or they have special guide characters.
ОРИЕНТИРЫ ПРОСТРАНСТВЕННЫХ ИЗМЕРЕНИЙ В СЕМАНТИКЕ ПАРАМЕТРИЧЕСКИХ ПРИЛАГАТЕЛЬНЫХ (НА МАТЕРИАЛЕ РУССКОГО И АНГЛИЙСКОГО ЯЗЫКОВ)
Authors: З.А. Харитончик
Published: October 2024

В статье прослеживается влияние ориентиров пространственных измерений, обозначаемых в русском и английском языках параметрическими прилагательными в основных значениях, на тип и характер их вторичных значений. Наличие ориентира пространственного измерения или его отсутствие являются важным фактором, предопределяющим развитие в семантике данных адъективных слов временных значений, а также детерминирующим основания и соответственно различия их количественных и оценочных значений.

The article is focused on the impact orientation of spatial dimensions denoted in Russian and English by parametric adjectives in major meanings has on the types and character of their secondary meanings. The presence or absence of the orientation of the spatial dimension designated turns out to be a significant factor which determines a possibility of temporary meanings in the semantics of these adjectives as well as lays the foundations for their different quantitative and evaluative meanings.
ЭМОЦИОНАЛЬНЫЙ КОМПОНЕНТ В СТРУКТУРЕ МОДУСА ЯЗЫКА (НА МАТЕРИАЛЕ СОПОСТАВЛЕНИЯ РУССКОГО И НЕМЕЦКОГО ЯЗЫКОВ)
Authors: Е.Ф. Киров , М. Мркаич , М.В. Беляева
Published: October 2024

В статье рассматриваются средства выражения эмоциональных состояний в русском и немецком языках. Изучение эмоций осуществляется по вводимым здесь понятиям эмотемы, т.е. общим эмоциональным идеям языка, которые, в свою очередь, реализуются посредством эмотивов в речи - конкретных языковых средств на фонемном, морфемном, лексическом и синтаксическом уровнях. Эмотемы могут выражаться эксплицитно, а могут иметь нулевое воплощение. Рассмотрены примеры в русском и немецком языках для иллюстрации приводимых положений. Актуальность и новизна исследования обусловлены построением собственной оригинальной траектории описания эмотем как элементов модуса языка и компаративным анализом эмотем в двух неродственных европейских языках. Показано, что самым распространенным способом выражения модуса в речи являются эмотивы лексического уровня, что подтверждает идею В.В. Виноградова о наличии в русском языке такой части речи, как модальные слова (модалемы).

The article discusses the means of expressing emotional states in Russian and German. The study of emotions is carried out according to the concepts of emoticons introduced here, i.e. general emotional ideas of language, which, in turn, are realized through emotives in speech - specific linguistic means at the phonemic, morphemic, lexical and syntactic levels. Emoticons can be expressed explicitly, or they can have zero embodiment. Examples in Russian and German are considered to illustrate the above provisions. The relevance and novelty of the study is due to the construction of its own original trajectory of describing emoticons as elements of the language mode and comparative analysis of emoticons in two unrelated European languages. It is shown that the most common way of expressing a mode in speech are emotives of the lexical level, which confirms V.V. Vinogradov’s idea of the presence in the Russian language of such a part of speech as modal words (modalems).
Пространственно-структурные особенности кварто-квинтового круга: Декартова Матрица
Authors: О.Н. Таганов
Published: October 2024

Автором статьи исследуется проблема корреляции свойств 12-элементной равномерно-темперированной музыкальной системы, ее плоскостной модели и правильного додекагона. В рамках плоскостной модели выявляется конструктивная роль диагонали связности {12/5} и предлагается формула для корреляции кварто-квинтового и хроматического представления системы. Впервые указывается на возможность трансляции плоскостной модели кварто-квинтового круга в трехмерную модель правильного многогранника (додекаэдра). На основе анализа свойств комплекса P-R-I-RI в музыке и аналогичных пространственно-симметричных комплексов в других сферах научных знаний предлагается обобщенная унификация их определения как Декартовой Матрицы. Выявляются константные «резонансно-узловые» элементы системы. Определяется ряд задач для дальнейших исследований.

The author of the paper investigates the problem of correlation between the properties of a 12-element even-tempered musical system, its planar model, and the proper dodecagon. Within the framework of the planar model, the constructive role of the connectivity diagonal {12/5} is revealed and a formula for correlating the fifths and chromatic representations of the system is proposed. For the first time, the possibility of translating the planar model of the circle of fifths into a three-dimensional model of a regular polyhedron (dodecahedron) is pointed. Based on the analysis of the properties of the P-R-I-RI complex in music and similar spatially symmetric complexes in other spheres of scientific knowledge, a generalized unification of their definition as a Cartesian Matrix is proposed. The constant "resonance-node" elements of the system are identified. A number of tasks for further research are defined.
A Bright Red Molecular Marker for Super Resolution Imaging of DNA Nanostructures
Authors: Chandra Mondal Iswar , Anjum Farhan , Salam Abdul , Deka Snata , Mandal Sayan , Karmakar Anirban , K. Nandi Chayan , Ghosh Subrata
Published: October 2024

SEZ-NDEA, a long-range emissive molecular marker, can be used in fluorescence microscopy for super-resolution imaging (SRRF) of DNA nanostructures. The developed probe stains the cell nucleus with minimum cytoplasmic leakage and good contrast. It showed good photostability in cellular medium.
Large scale compartmental model-based study of preclinical pharmacokinetic data and its impact on compound triaging in drug discovery
Authors: Zhang Peter Zhiping , Yu Xiang , Gibson Christopher , Ballard Jeanine , Smith Dustin , Esquivel Fagiani Facundo
Published: October 2024

Reliable and robust human dose prediction plays a pivotal role in compound optimization and advancement in drug discovery. The prediction of human dose in discovery requires proper modelling of preclinical intravenous (IV) pharmacokinetic (PK) data which is usually achieved either through non-compartmental analysis (NCA) or compartmental analysis. While NCA is straightforward, it loses valuable information about the shape of PK curves. In contrast, compartmental analysis offers a more comprehensive interpretation but poses challenges in scaling up for high-throughput applications in discovery. To address this challenge, we developed computational frameworks, termed Compartmental PK (CPK) and Automated Dose Prediction (ADP), to enable automated compartmental model-based IV PK data modeling, translation, and simulation for human dose prediction in compound triage and optimization. With CPK and ADP, we analyzed compounds with data collected at MRL between 2013 and 2023 to quantitatively characterize the impact of different PK modeling and simulation methods on human dose prediction. Our study revealed that, despite minimal impact on estimating animal PK parameters, different methods significantly impacted predicted human dose, exposure, and Cmax, driven more by different simulation assumptions than by the PK modeling itself. CPK-ADP therefore enables us to efficiently perform complex human dose predictions on a large scale while integrating the latest and best information available on absorption, distribution, and clearance to support decision making in discovery.
Thermo-reversible gelation of self-assembled conducting polymer colloids
Authors: Damani Vidhika S. , Xie Xinran , Daso Rachel E. , Suman Khushboo , Ghasemi Masoud , Xie Weiran , Wu Ruiheng , Wu Yuhang , Chao Calvin L. , Alberto Julian E. , Lorch Casey M. , Yang Ai-Nin , Nguyen Dan My , Shrestha Tulaja , Otero Kayla , Lo Chun-Yuan , Pochan Darrin , Gomez Enrique D. , Rivnay Jonathan , Kayser Laure V.
Published: October 2024

Electrically conductive hydrogels based on conducting polymers have found increased use in bioelectronics due to their low moduli that mimic biological tissues, their ability to transport both ionic and electronic charges, and their ease of processing in various form factors via printing or injection. Current approaches towards conductive hydrogels, however, rely on covalent and therefore irreversible crosslinking mechanisms. Here, we report a thermo-responsive conducting polymer (TR-CP) that undergoes a fully reversible non-covalent crosslinking at 35 °C within less than a minute to form conductive hydrogels. The TR-CP is based on a block polyelectrolyte complex, that self-assembles into well-defined colloidal particles in water which undergo an isovolumetric sol-gel transition just below physiological temperature. The hydrogels have tunable mechanical properties in the 20 to 200 Pa range, are stable at various pH and salt conditions, self-healing, injectable, and biocompatible in vitro and in vivo. We demonstrate that the TR-CPs can be used to fabricate sensitive, conformal and reusable electrodes for surface electromyography. This unique material provides exciting opportunities for stimuli-responsive and adaptive bioelectronics.
Solid-phase guanidyl-formation triggered peptide stapling and cyclization: A robust platform for improving multiple properties of bioactive peptides
Authors: Wang Nan , Chen Baobao , Li Xiang , Hu Hong-Gang
Published: October 2024

Stapled or cyclic peptides offered advantageous membrane permeability and proteolytic stability to linear counterparts. We herein synthesized a series of S-alkyl-isothiourea building blocks, which could be conveniently coupled with one or two amine groups in both i,i+4 and i,i+7 space located within the peptides, enabling the silver-promoted solid-phase guanidyl-formation (SSG) peptide stapling. The guanidyl stapled peptides, characterized with highly hydrophilic and cationic properties, could be readily labelled by biotin, polyethylene glycol and fluorescent motif using the pre-made functionalized bis-S-alkyl-isothiourea. SSG reactions could be rendered for generating double-stapled peptide, and notably, tri-guanidyl bicyclic peptide with the aid of tri-S-alkyl-isothiourea donor. When compared with hydrocarbon stapled and/or linear peptide, SSG stapled peptides exhibited enhanced proteolytic tolerance, remarkable hydrophilicity, membrane penetration and thus higher in vitro biological activities. Our developed SSG peptide stapling and cyclization strategy served as a meaningful tool in modifying other peptide fragments and offering the potent peptide therapeutic candidates.
Editorial Address & Advisory Board
Authors: Oegema Gerbern , Rosini Amanda , MacLeod Elyse , Retallick Shaun
Published: October 2024

The first issue of volume five of the Journal of the Council for Research on Religion (JCREOR) is a call by the editors to examine and understand social cohesions and conflicts, with particular interest in what role religion or religious traditions play within communities of diverse peoples. We sought first to understand how tension points arise within communities, and second, to examine the role played by religion in creating or appeasing these tension points. This issue is thus dedicated to probing, not only the tensions that arise within religiously diverse communities but the solutions that are developed in response to criticism or conflict.
The studies in this issue address: the fractures that have been created in the Orthodox world by the Russian Orthodox Church’s support for the ongoing war in Ukraine; the tensions between liberal and traditional standpoints when discussing the Vedāntic tradition and the philosophy of the Upanishads; the tension and cohesion created by how different Turkish faith communities have been negotiating their role in the preservation of Ottoman architectural heritage; and, finally, how attempts at creating social cohesion in the Southern state of Karnataka have led to tensions between Muslim and Hindu communities.
Association of Spexin Hormone Levels with Metabolic Disturbance in Women with Polycystic Ovarian Syndrome
Authors: F. salih Ruaa , Abd Al-Qadir Al-Moayad Hala , Abbas Firas , I. Alezzi Jalil , Saleh Mohammed Asrar
Published: October 2024

Background: Polycystic ovarian syndrome is affecting around 5–15% of females. Spexin hormone, identified as neuropeptide Q, has been newly recognized by bioinformatics methods.
Objective: To evaluate the relationship concerning levels of spexin hormone with   metabolic disruption in women with polycystic ovarian syndrome.
Patients and Methods: A case-control study carried out in the department of Obstetrics and Gynecology in Al-Imamain Al-Khademain medical city/Baghdad, Iraq, from Jan 1, 2022, to the end of Dec 31, 2022. The study sample comprises, 192 participants aged 18-45 years were joined and allocated into a case group (96 women with PCOS) and a control group (96 women without PCOS).
Results: Mean value of spexin hormone  was (2.7±0.3 ng/mL) in the PCOS group, while it was (3.5±0.7 ng/mL) in the control group; fasting blood sugar shows significant association with a negative, weak correlation with Spexin in patients (P-value= 0.005), Insulin shows significant association with inverse correlation with Spexin in patients (P-value= 0.04), Homeostasis model valuation of insulin resistance (HOMA-IR) shows significant association with inverse correlation with Spexin in patients (P-value= 0.003). Spexin had a significant inverse correlation with LH, SHBG, testosterone, FAI, and Dehydroepiandrosterone.
Conclusion: Serum level of spexin hormone was meaningfully decreased in patients with PCOS than that in healthy women.