bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of integration mode proton imaging with a single CMOS detector for a small animal irradiation platform
Authors: Schnürle Katrin , Bortfeldt Jonathan , Englbrecht Franz Siegfried , Gianoli Chiara , Hartmann Jens , Hofverberg Petter , Meyer Sebastian , Niepel Katharina , Yohannes Indra , Vidal Marie , Landry Guillaume , Hérault Joël , Schreiber Jörg , Parodi Katia , Würl Matthias
Published: January 2023

A novel irradiation platform for preclinical proton therapy studies foresees proton imaging for accurate setup and treatment planning. Imaging at modern synchrocyclotron-based proton therapy centers with high instantaneous particle flux is possible with an integration mode setup. The aim of this work is to determine an object’s water-equivalent thickness (WET) with a commercially available large-area CMOS sensor. Image contrast is achieved by recording the proton energy deposition in detector pixels for several incoming beam energies (here, called probing energies) and applying a signal decomposition method that retrieves the water-equivalent thickness. A single planar 114 mm × 65 mm CMOS sensor (49.5 µm pixel pitch) was used for this study, aimed at small-animal imaging. In experimental campaigns, at two isochronous cyclotron-based facilities, probing energies suitable for small-animal-sized objects were produced once with built-in energy layer switching and the other time, using a custom degrader wheel. To assess water-equivalent thickness accuracy, a micro-CT calibration phantom with 10 inserts of tissue-mimicking materials was imaged at three phantom-to-detector distances: 3 mm, 13 mm, and 33 mm. For 3 mm and 13 mm phantom-to-detector distance, the average water-equivalent thickness error compared to the ground truth was about 1% and the spatial resolution was 0.16(3) mm and 0.47(2) mm, respectively. For the largest separation distance of 33 mm air gap, proton scattering had considerable impact and the water-equivalent thickness relative error increased to 30%, and the spatial resolution was larger than 1.75 mm. We conclude that a pixelated CMOS detector with dedicated post-processing methods can enable fast proton radiographic imaging in a simple and compact setup for small-animal-sized objects with high water-equivalent thickness accuracy and spatial resolution for reasonable phantom-to-detector distances.
Recognition of Pep-13/25 MAMPs of Phytophthora localizes to an RLK locus in Solanum microdontum
Authors: Lin Xiao , Torres Ascurra Yerisf Carla , Fillianti Happyka , Dethier Laura , de Rond Laura , Domazakis Emmanouil , Aguilera-Galvez Carolina , Kiros Afewerki Yohannes , Jacobsen Evert , Visser Richard G. F. , Nürnberger Thorsten , Vleeshouwers Vivianne G. A. A.
Published: January 2023

Pattern-triggered immunity (PTI) in plants is mediated by cell surface-localized pattern recognition receptors (PRRs) upon perception of microbe-associated molecular pattern (MAMPs). MAMPs are conserved molecules across microbe species, or even kingdoms, and PRRs can confer broad-spectrum disease resistance. Pep-13/25 are well-characterized MAMPs in Phytophthora species, which are renowned devastating oomycete pathogens of potato and other plants, and for which genetic resistance is highly wanted. Pep-13/25 are derived from a 42 kDa transglutaminase GP42, but their cognate PRR has remained unknown. Here, we genetically mapped a novel surface immune receptor that recognizes Pep-25. By using effectoromics screening, we characterized the recognition spectrum of Pep-13/25 in diverse Solanaceae species. Response to Pep-13/25 was predominantly found in potato and related wild tuber-bearing Solanum species. Bulk-segregant RNA sequencing (BSR-Seq) and genetic mapping the response to Pep-25 led to a 0.081 cM region on the top of chromosome 3 in the wild potato species Solanum microdontum subsp. gigantophyllum. Some BAC clones in this region were isolated and sequenced, and we found the Pep-25 receptor locates in a complex receptor-like kinase (RLK) locus. This study is an important step toward the identification of the Pep-13/25 receptor, which can potentially lead to broad application in potato and various other hosts of Phytophthora species
Plant growth-promoting rhizobacteria: Salt stress alleviators to improve crop productivity for sustainable agriculture development
Authors: Kumawat Kailash Chand , Sharma Barkha , Nagpal Sharon , Kumar Ajay , Tiwari Shalini , Nair Ramakrishnan Madhavan
Published: January 2023

Soil salinity, a growing issue worldwide, is a detrimental consequence of the ever-changing climate, which has highlighted and worsened the conditions associated with damaged soil quality, reduced agricultural production, and decreasing land areas, thus resulting in an unsteady national economy. In this review, halo-tolerant plant growth-promoting rhizo-microbiomes (PGPRs) are evaluated in the salinity-affected agriculture as they serve as excellent agents in controlling various biotic–abiotic stresses and help in the augmentation of crop productivity. Integrated efforts of these effective microbes lighten the load of agro-chemicals on the environment while managing nutrient availability. PGPR-assisted modern agriculture practices have emerged as a green strategy to benefit sustainable farming without compromising the crop yield under salinity as well as salinity-affected supplementary stresses including increased temperature, drought, salinity, and potential invasive plant pathogenicity. PGPRs as bio-inoculants impart induced systemic tolerance (IST) to plants by the production of volatile organic compounds (VOCs), antioxidants, osmolytes, extracellular polymeric substances (EPS), phytohormones, and ACC-deaminase and recuperation of nutritional status and ionic homeostasis. Regulation of PGPR-induced signaling pathways such as MAPK and CDPK assists in salinity stress alleviation. The “Next Gen Agriculture” consists of the application of designer crop microbiomes through gene editing tools, for instance, CRISPR, and engineering of the metabolic pathways of the microbes so as to gain maximum plant resistance. The utilization of omics technologies over the traditional approaches can fulfill the criteria required to increase crop yields in a sustainable manner for feeding the burgeoning population and augment plant adaptability under climate change conditions, ultimately leading to improved vitality. Furthermore, constraints such as the crop specificity issue of PGPR, lack of acceptance by farmers, and legal regulatory aspects have been acknowledged while also discussing the future trends for product commercialization with the view of the changing climate.
Indonesian public officials after erroneous statements about COVID-19: An application of image restoration theory
Authors: Andarini Rindang Senja , Pratiwi Miftha , Setiyowati Rini , Santoso Anang Dwi
Published: January 2023

Introduction

This study aimed to examine the tactics and strategies of Indonesian public officials to restore their reputation after making false claims and policies on coronavirus 2019 (COVID-19). The significance of this study can be separated into two categories. First, the application of image restoration theory to public organizations and public officials is uncommon. Second, it is essential to analyze the application of this theory to diverse social, political, and economic contexts of emerging nations; as a result, these distinctions may lead to varied research conclusions.

Methodology

A dataset of 2,000 Instagram posts by Indonesian public officials was generated to conduct the content analysis.

Results

This study found that reducing offensiveness, evading responsibility, and taking corrective action are the three most commonly seen practices followed by Indonesian public officials. This study confirms that denial and mortification are employed exceedingly infrequently in non-Western countries because both these strategies are believed to diminish the image of public leaders in public view.

Discussion

This study presents the practical implications that public officials or public relations experts who represent them must be cautious since it can have severe implications on their reputation. This study also argues that erroneous claims when posted by public officials attract unwanted public attention and negatively affect their image. Furthermore, this study provides practical implications for public officials and their representatives to be more cautious while handling media accounts.
Facilitating animacy perception by manipulating stimuli exposure time
Authors: Saito Toshiki , Motoki Kosuke , Nouchi Rui , Sugiura Motoaki
Published: January 2023

Animacy perception—discriminating between animate and inanimate visual stimuli—is the basis for engaging in social cognition and for our survival (e.g., avoiding potential danger). Previous studies indicate that factors in a target, such as the features or motion of a target, enhance animacy perception. However, factors in a perceiver, such as the visual attention of a perceiver to a target, have received little attention from researchers. Research on judgment, decision-making, and neuroeconomics indicates the active role of visual attention in constructing decisions. This study examined the role of visual attention in the perception of animacy by manipulating the exposure time of targets. Among Studies 1a to 1c conducted in this study, participants saw two face illustrations alternately; one of the faces was shown to be longer than the other. The participants chose the face that they considered more animated and rounder. Consequently, longer exposure time toward targets facilitated animacy perception and preference rather than the perception of roundness. Furthermore, preregistered Study 2 examined the underlying mechanisms. The results suggest that mere exposure, rather than orienting behavior, might play a vital role in the perception of animacy. Thus, in the reverse relationship between visual attention and animacy perception, animate objects capture attention—attention results in the perception of animacy.
fMRI evidence that hyper-caricatured faces activate object-selective cortex
Authors: Elson Ryan , Schluppeck Denis , Johnston Alan
Published: January 2023

Many brain imaging studies have looked at the cortical responses to object categories and faces. A popular way to manipulate face stimuli is by using a “face space,” a high dimensional representation of individual face images, with the average face located at the origin. However, how the brain responds to faces that deviate substantially from average has not been much explored. Increasing the distance from the average (leading to increased caricaturing) could increase neural responses in face-selective regions, an idea supported by results from non-human primates. Here, we used a face space based on principal component analysis (PCA) to generate faces ranging from average to heavily caricatured. Using functional magnetic resonance imaging (fMRI), we first independently defined face-, object- and scene-selective areas with a localiser scan and then measured responses to parametrically caricatured faces. We also included conditions in which the images of faces were inverted. Interestingly in the right fusiform face area (FFA), we found that the patterns of fMRI response were more consistent as caricaturing increased. However, we found no consistent effect of either caricature level or facial inversion on the average fMRI response in the FFA or face-selective regions more broadly. In contrast, object-selective regions showed an increase in both the consistency of response pattern and the average fMRI response with increasing caricature level. This shows that caricatured faces recruit processing from regions typically defined as object-selective, possibly through enhancing low-level properties that are characteristic of objects.
Explaining the stability of cooperation in agricultural industry chains based on the institutional theory: Multiple mediating effects of perceived value and trust
Authors: Zhao Rong-Rong , Wang Qiao , Tian Yuan , Chen Qiu-Hua
Published: January 2023

Introduction

Due to the superposition of multiple complex socioeconomic environments and the complexity and uncertainty of the agricultural industry chain itself, the agricultural industry chain has become unstable, jeopardizing its long-term sustainability.

Methods

The purpose of this study is to construct and validate a stability mechanism model of cooperative relationships within agricultural industry chains based on the institutional theory. The questionnaire survey method was used for empirical analysis.

Results

The results show that imitative pressure, mandatory pressure, and normative pressure have significant positive effects on the stability of cooperative relationships in agricultural industrial chains. Besides, perceived benefits, perceived risks, and trust play composite multiple mediating roles between imitative pressure and cooperation stability, and between normative pressure and cooperation stability in agricultural industrial chains. Perceived benefits and trust play partial mediating roles in the stability of cooperative relationships between mandatory pressure and agricultural industrial chains.

Discussion

This study is conducive to further understanding the cooperative psychology of agricultural industry chain operators. And this research can provide a reference for managers to take targeted measures to deal with the instability in the development of agricultural industry chains.
Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons
Authors: Chen Huanxin , He Ting , Li Meiyi , Wang Chunlian , Guo Chen , Wang Wei , Yu Baocong , Huang Jintao , Cui Lijun , Guo Ping , Yuan Yonggui , Tan Tao
Published: January 2023

The muscarinic acetylcholine receptor (mAChR) antagonist, scopolamine, has been shown to have a rapid antidepressant effect. And it is believed that GABAergic interneurons play a crucial role in this action. Therefore, characterizing the modulation effects of mAChR on GABAergic interneurons is crucial for understanding the mechanisms underlying scopolamine’s antidepressant effects. In this study, we examined the effect of mAChR activation on the excitatory synaptic transmissions in two major subtypes of GABAergic interneurons, somatostatin (SST)- and parvalbumin (PV)-expressing interneurons, in the anterior cingulate cortex (ACC). We found that muscarine, a mAChR agonist, non-specifically facilitated the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) in both SST and PV interneurons. Scopolamine completely blocked the effects of muscarine, as demonstrated by recovery of sESPCs and mEPSCs in these two types of interneurons. Additionally, individual application of scopolamine did not affect the EPSCs of these interneurons. In inhibitory transmission, we further observed that muscarine suppressed the frequency of both spontaneous and miniature inhibitory postsynaptic currents (sIPSCs and mIPSCs) in SST interneurons, but not PV interneurons. Interestingly, scopolamine directly enhanced the frequency of both sIPSCs and mIPSCs mainly in SST interneurons, but not PV interneurons. Overall, our results indicate that mAChR modulates excitatory and inhibitory synaptic transmission to SST and PV interneurons within the ACC in a cell-type-specific manner, which may contribute to its role in the antidepressant effects of scopolamine.
A systematic review and meta analysis on burnout in physicians during the COVID-19 pandemic: A hidden healthcare crisis
Authors: Macaron Marie Michele , Segun-Omosehin Omotayo Ayomide , Matar Reem H. , Beran Azizullah , Nakanishi Hayato , Than Christian A. , Abulseoud Osama A.
Published: January 2023

Objective

This systematic review and meta-analysis aims to explore overall prevalence of burnout among physicians during early and late COVID-19 pandemic and geographical differences in burnout.

Methods

This review was registered prospectively with PROSPERO (CRD42022327959). A comprehensive search of several databases, including Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, PsycINFO, and Scopus, spanning from December 2019 to May 2022 was conducted. Eligible studies included physicians or medical professionals including physicians that worked directly or indirectly with COVID-19 patients, whilst reporting burnout outcomes using a validated scale. Literature that did not include physicians or did not occur in a hospital setting were excluded. Literature including medical students were also excluded.

Results

Forty-five observational studies were included, all of which were cross-sectional studies. The pooled estimate of overall prevalence of burnout was 54.60% (95% CI: 46.7, 62.2). Mean emotional exhaustion, depersonalization, and personal accomplishment was found to be 22.06% (95% CI: 18.19, 25.94), 8.72 (95% CI: 6.48, 10.95) and 31.18 (95% CI: 27.33, 35.03) respectively. Frontline workers displayed higher rates of burnout than second-line healthcare workers (HCW) (OR: 1.64, 95% CI: 1.13, 2.37). Studies from the early pandemic period reported burnout prevalence of 60.7% (95% CI: 48.2, 72) compared to a prevalence of 49.3% (95% CI: 37.7, 60.9) from the late pandemic period. Geographically, burnout was highest amongst Middle East and North Africa (MENA) studies (66.6%, 95% CI: 54.7, 78.5), followed by Europe (48.8%, 95% CI: 40.3, 57.3) and then South America (42%, 95% CI: –0.4, 84.4). Lastly, burnout prevalence overall (OR = 0.77, 95% CI: 0.36, 1.67) emotional exhaustion (MD = –0.36, 95% CI: –4.64, 3.91), depersonalization (MD = –0.31, 95% CI: –1.80, 1.18), and personal accomplishment (MD = 0.55, 95% CI: –0.73, 1.83) were found comparable between physicians and nurses.

Conclusion

COVID-19 has had significant consequences on HCW burnout. Further research is needed to examine early signs of burnout and to develop effective coping strategies.
Development and implementation of the ECHO model in a school setting to address youth electronic cigarette use in Kansas: A protocol
Authors: Leavens Eleanor L. S. , Roberts Jordan , Faseru Babalola , Thompson Mark , Denes-Collar Karin , Shah Hina
Published: January 2023

Introduction

Schools remain at the frontlines of addressing issues, such as e-cigarette use, that impact students. Despite e-cigarette use remaining a significant public health concern in the U.S., schools have limited resources (e.g., staff, capacity, programming) to address it, especially in rural and frontier areas. This ECHO Pilot Project aimed to build capacity and equip schools and school staff in the state of Kansas to address high rates of youth e-cigarette use by providing prevention support and information on best practices for e-cigarette cessation.

Methods and analysis

The pilot used the established Project ECHO model to disseminate evidence-based strategies for e-cigarette prevention and cessation among youth to schools across Kansas. The pilot selected 20 interdisciplinary school teams representing both rural and urban middle and high schools across the state to participate in seven ECHO sessions. ECHO sessions proceeded throughout Fall 2021, with the final session in Spring 2022. School participants completed pre-post surveys as well as component-specific surveys following each ECHO session. In addition, each school team created an individualized action plan to comprehensively address e-cigarette use at their school based on the information provided throughout the ECHO. Survey data, school tobacco/nicotine policies, and action plans will be analyzed to assess process and final outcomes.

Discussion

If successful, this pilot will demonstrate that the ECHO model is an effective platform for building school staff knowledge and skills to implement evidence-based strategies in both urban and rural settings. It is anticipated that the pilot will build capacity and equip schools and school staff to address high rates of youth e-cigarette use by providing support for school-based prevention programs and referrals for e-cigarette cessation which will lessen the burden of nicotine-related problems in Kansas schools and communities. Finally, the pilot will provide evidence that the ECHO model can be successfully and equitably applied in a school setting and may be a viable method for addressing other public health-related issues faced by schools.
COVID-19 risk, attitudes and behaviour study (CRAB study): A knowledge, attitudes, and practise qualitative study of COVID-19 in the Royal Navy
Authors: Woolley Stephen D. , Chambers Robert , Bishop Jonathan R. B. , Logan Amy , McMillan Peter , Fletcher Thomas E. , Taegtmeyer Miriam , O'Shea Matthew K.
Published: January 2023

Introduction

Outbreaks of SARS-CoV-2 onboard maritime platforms spread rapidly and have high attack rates. The aim of the COVID-19 Risk, Attitudes and Behaviour (CRAB) study was to investigate the knowledge, attitudes, and practises in the Royal Navy in relation to COVID-19 prevention.

Methods

The CRAB study was a cross-sectional survey, using a census sampling method, conducted in May and June 2021. An online questionnaire was distributed to all serving Royal Navy regular personnel using either the MyNavy application or via a QR code through email for a continuous 14 day period. The questionnaire was based on an existing validated questionnaire used for avian influenza epidemics. Questions investigated individual perceptions of COVID-19 seriousness, compliance with prevention methods, explored vaccination intention and vaccine hesitancy (unvaccinated individuals who declined or were unsure about receiving a COVID-19 vaccine). The chi-squared test of best fit was used to compare the demographic responses against the whole organisation, with p-value < 0.05 deemed significant. Odds ratios were used to investigate associations between demographic groups and responses to questions, with an odds ratio crossing 1.0 deemed non-significant.

Results

The response rate was 6% (2,080/33,200), with 315 responses collated in the pilot phase and 1,765 in the main study phase. Male participants were less likely to rate COVID-19 as serious (OR 0.34; 95% CI: 0.23–0.49). BAME ethnicity (OR 2.41; 95% CI: 1.12–5.17) rated it as more serious. At the time of the study 62% of respondents had received one dose of a COVID-19 vaccine. In the 797 unvaccinated personnel, vaccine hesitancy accounted for 24.2% (193/797), of whom 136 were white males. Those who had a higher COVID-19 serious rating, the most significant factor for non-adherence to COVID-19 prevention measures in both vaccinated (OR 1.61 [95%CI: 1.20–2.17]) and vaccine-hesitant (OR 3.24 [95%CI: 1.63–6.41]) individuals was colleagues' non-adherence. The most trusted source of information on vaccines was provided by the Defence Medical Services (77.2% [1,606/2,080]).

Conclusion

This study has identified reasons for COVID-19 protective measure adherence, sources of information trusted by respondents and vaccine hesitancy, in the Royal Navy. The questionnaire can be used to investigate attitudes and behaviours in future emerging infectious diseases.
Associations between neighborhood environment and sense of community belonging in urban China: Examining mediation effects of neighborly interactions and community satisfaction
Authors: Du Yang , Jiang Huaxiong , Huang Zhuo , Yang Haoran
Published: January 2023

Introduction

Improving sense of community belonging (SCB) would help people live longer, happier lives. Although the importance of neighborhood environment on SCB is stressed in the literature, few studies have paid attention to perceived environment, as well as consider mediation effects such as neighborhood social interactions and place satisfaction.

Methods

Relied on a sample of 1051 respondents in Shanghai in 2018, this study investigates the associations between both objective and perceived neighborhood environment attributes and SCB in urban China, mediated by neighborly interactions and community satisfaction using structural equation modeling.

Results

The results suggest that the influence of perceived neighborhood environment on SCB is more prominent than that of objective neighborhood environment. In detail, perceived pedestrian facilities and perceived leisure facilities are vital to SCB, while among objective neighborhood environmental elements, the influence of land use entropy, park density and street greenery are significant. Then, neighborhood environmental attributes can influence SCB by affecting neighborly interactions and community satisfaction. We also identify gender differences in the effects of neighborhood environment upon SCB.

Discussion

Given increasing awareness of the connection, neighborhood environment may prove to be valuable assets to improve individuals' psychosocial constructs such as SCB.
Anti-SARS-CoV-2 spike IgG following injection of the third dose vaccine: A systematic review with meta-analysis of heterologous versus homologous vaccination
Authors: Mojadadi Mohammad-Shafi , Javadinia Seyed Alireza , Attarian Fahimeh , Samami Elham , Sobhani Mona
Published: January 2023

Background

The mass vaccination is a key strategy to prevent and control the coronavirus disease 2019 (COVID-19) pandemic. Today, several different types of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed worldwide. These vaccines are usually administered in a two-dose schedule, and the third dose is currently being administered in most countries. This study aimed to systematically review and meta-analyze the immunogenicity of heterologous vs. homologous vaccination after administration of the third dose of COVID-19 vaccines.

Methods

Electronic databases and websites including Scopus, PubMed, Web of Science, and Google scholar were searched for relevant randomized clinical trial (RCT) studies. After applying the inclusion and exclusion criteria, a total of three RCTs were included in the study. These RCTs were included 2,613 healthy adults (18 years or older and without a history of laboratory-confirmed COVID-19) with 15 heterologous and five homologous prime-boost vaccination regimens. Anti-SARS-CoV-2-spike IgG levels at day 28 after administration of the third dose, were compared between the heterologous and homologous regimens.

Results

The highest antibody responses had been reported for the homologous vaccination regimen of m1273/m1273/m1273 (Moderna), followed by the heterologous regimen of BNT/BNT/m1273. In addition, the immunogenicity of viral vector and inactivated vaccines was remarkably enhanced when they had been boosted by a heterologous vaccine, especially mRNA vaccines.

Conclusion

This systematic review suggests that mRNA vaccines in a homologous regimen induce strong antibody responses to SARS-CoV-2 compared to other vaccine platforms. In contrast, viral vector and inactivated vaccines show a satisfactory immunogenicity in a heterologous regimen, especially in combination with mRNA vaccines.
Phase-dependent strategy to mimic quantum phase transitions
Authors: Zhou Yuan , Cao Lian-Zhen , Wang Qing-Lan , Hu Chang-Sheng , Zhang Zhu-Cheng , Xiong Wei
Published: January 2023

This study proposes a hybrid quantum system of an ensemble of collective spins coupled to a surface acoustic wave (SAW) cavity through a sideband design. Assisted by a dichromatic optical drive with a phase-dependent control, this spin ensemble can effectively mimic different types of long-range Lipkin–Meshkov–Glick (LMG) interactions and then undergo quantum phase transitions (QPTs) due to phase-induced spontaneous symmetry breaking (SSB). In addition, this phase-controlled scheme also ensures the dynamical preparation of the spin-squeezed state (SSS), which may be a useful application in quantum measurement. This study is a fresh attempt at quantum manipulation based on acoustic control and also provides a promising route toward useful applications in quantum information processing, especially the adiabatic preparation of multiparticle-entangled ground states via QPTs; i.e., the Greenberger–Horne–Zeilinger (GHZ) or W-type states.
Neutral winds from mesosphere to thermosphere—past, present, and future outlook
Authors: Dhadly Manbharat , Sassi Fabrizio , Emmert John , Drob Douglas , Conde Mark , Wu Qian , Makela Jonathan , Budzien Scott , Nicholas Andy
Published: January 2023

The Earth’s upper atmosphere (85–550 km) is the nearest region of geospace and is highly dynamic in nature. Neutral winds impact a large portion of the dynamics in this region. They play a critical role in determining the state of the ionosphere-thermosphere system at almost all latitudes and altitudes. Their influences range from wave breaking/dissipation in the mesosphere and lower thermosphere to global redistribution of energy and momentum deposited at high latitudes by the magnetosphere. Despite their known importance, global geospace neutral winds have remained one of the least sampled state parameters of the Earth’s upper atmosphere and are still poorly characterized even after multiple decades of observations. This paper presents an overview of historical neutral wind measurements and the critical need for their global height-resolved measurements. Some satellite missions are still operational and deliver valuable information on the contribution of neutral winds in global atmospheric dynamics. However, many significant gaps remain in their global monitoring, and our current understanding of the drivers of neutral winds is incomplete. We discuss the challenges posed by these measurement gaps in understanding geospace physics and weather. Further, we propose some wind observation solutions, including the simultaneous operations of upcoming NASA DYNAMIC and GDC missions as well as support for the development of ground-based observing methodologies, that will lead to fundamental advances in geospace science and address humanity’s emerging space needs.
Testing parity symmetry of gravity with gravitational waves
Authors: Qiao Jin , Li Zhao , Zhu Tao , Ji Ran , Li Guoliang , Zhao Wen
Published: January 2023

The examination of parity symmetry in gravitational interactions has drawn increasing attention. Although Einstein’s General Relativity is parity-conserved, numerous theories of parity-violating (PV) gravity in different frameworks have recently been proposed for different motivations. In this review, we briefly summarize the recent progress of these theories, and focus on the observable effects of PV terms in the gravitational waves (GWs), which are mainly reflected in the difference between the left-hand and right-hand polarization modes. We are primarily concerned with the implications of these theories for GWs generated by the compact binary coalescences and the primordial GWs generated in the early Universe. The deviation of GW waveforms and/or primordial power spectrum can always be quantified by the energy scale of parity violation of the theory. Applying the current and future GW observation from laser interferometers and cosmic microwave background radiation, the current and potential constraints on the PV energy scales are presented, which indicates that the parity symmetry of gravity can be tested in high energy scale in this new era of gravitational waves.
Improving women's purchasing power through land-enhancing technologies: The case of bio-reclamation of degraded lands in Niger
Authors: Singbo Alphonse , Quarshies James , Bonou Alice , Lokossou Jourdain , Fatondji Dougbedji , Dandedjrohoun Lidia
Published: January 2023

In Niger, about 50% of the land surface is composed of degraded lateritic soils, and rural women farmers have limited access to productive land. Targeting largely marginalized rural women with bio-reclamation of degraded land (BDL) technologies restores their rights to earn a livelihood through agriculture. This study examines the determinants and impacts of land-enhancing technology on women farmers in Niger. Data were collected from 1,205 randomly selected women farmers in the Maradi and Zinder regions. The sample included 69% of participants into BDL program and 31% of non-participants. To account for selection bias from observable and unobservable factors, an endogenous switching regression (ESR) model was used to estimate the impact of BDL technology on women's household income. A simple probit model was used to analyze the determinants of participation. The results show that key determinants of participation in BDL include income level before participation in BDL, household size, age of participants, number of women in the household, number of children under 5 years old, sex of household head, age of household head, and institutional support. Participation in BDL positively influences participants' income (+14%); non-participants may not benefit from participating as they would probably lose 31% of their income, and the impact of participation in BDL varies widely across regions. Before the advent of BDL, the income of non-participants was higher than that of participants by 25%. It can be inferred that BDL is a pro-poor technology that is not beneficial to all women farmers. This study makes a critical contribution to the literature on land-enhancing technologies. It suggests that the impact of land-enhancing technologies, such as BDL, is closely linked to spatial, economic, environmental, temporal, and cultural contexts. Accordingly, land-enhancing technologies should target locations with large percentages of degraded farmlands and the poorest farmers. These results contribute to food security and poverty alleviation policies in rural dryland areas.
Restructuring surgical training after COVID-19 pandemic: A nationwide survey on the Italian scenario on behalf of the Italian polyspecialistic young surgeons society (SPIGC)
Authors: Gallo Gaetano , Guaitoli Eleonora , Barra Fabio , Picciariello Arcangelo , Pasculli Alessandro , Coppola Alessandro , Pertile Davide , Meniconi Roberto Luca ,   SPIGC Surgical Training Working Group
Published: January 2023

Introduction

The COVID-19 pandemic has led to the disruption of surgical training. Lack of communication, guidelines for managing clinical activity as well as concerns for safety in the workplace appeared to be relevant issues. This study aims to investigate how surgical training has been reorganized in Italy, almost 2 years after the outbreak of COVID-19 pandemic.

Materials and methods

A 16-item-electronic anonymous questionnaire was designed through SurveyMonkey© web application. This survey was composed of different sections concerning demographic characteristics and impacts of the second COVID-19 pandemic wave on surgical and research/didactic activities. Changes applied in the training programme and activities carried out were also investigated. The survey was carried out in the period between June and October 2021.

Results

Four hundred and thirty responses were collected, and 399 were considered eligible to be included in the study analysis. Three hundred and thirty-five respondents continued working in Surgical Units, with a significant reduction (less than one surgical session per week) of surgical sessions in 49.6% of them. With concern to didactic and research activities, 140 residents maintained their usual activity, while 116 reported a reduction. A sub-group analysis on resident moved to COVID-19 departments showed a reduction of research activities in 35% of them. During the period considered in this survey, the surgical training program was not substantially modified for most of participants (74.6%).

Conclusion

Our survey demonstrated that surgical residency programs haven't improved 2 years after the beginning of the pandemic. Further improvements are needed to guarantee completeness of surgical training, even in emergency conditions.
Nickel Alloying in Carbon Steel: Fundamentals and Applications
Authors: Mohrbacher Hardy , Kern Andreas
Published: January 2023

Nickel is an important and widely used alloying element in carbon steels. Some of its prominent metallurgical effects in these steels are moderate solid solution strengthening, mild hardenability and, importantly, a strong promotion of toughness, especially at low temperatures. The first uses of nickel as an alloying element in commercial steel production date back to the early 20th century. The aim of the current review is to give the reader a thorough and concise overview of nickel functionalities relevant to modern carbon steel production. The interaction of nickel with other alloying elements and processing conditions is also considered. Examples will be given demonstrating the advantages of nickel alloying in selected steel grades and applications.
Research and Implementation of High Computational Power for Training and Inference of Convolutional Neural Networks
Authors: Li Tianling , He Bin , Zheng Yangyang
Published: January 2023

Algorithms and computing power have consistently been the two driving forces behind the development of artificial intelligence. The computational power of a platform has a significant impact on the implementation cost, performance, power consumption, and flexibility of an algorithm. Currently, AI algorithmic models are mainly trained using high-performance GPU platforms, and their inferencing can be implemented using GPU, CPU, and FPGA. On the one hand, due to its high-power consumption and extreme cost, GPU is not suitable for power and cost-sensitive application scenarios. On the other hand, because the training and inference of the neural network use different computing power platforms, the data of the neural network model needs to be transmitted on platforms with varying computing power, which affects the data processing capability of the network and affects the real-time performance and flexibility of the neural network. This paper focuses on the high computing power implementation method of the integration of convolutional neural network (CNN) training and inference in artificial intelligence and proposes to implement the process of CNN training and inference by using high-performance heterogeneous architecture (HA) devices with field programmable gate array (FPGA) as the core. Numerous repeated multiplication and accumulation operations in the process of CNN training and inference have been implemented by programmable logic (PL), which significantly improves the speed of CNN training and inference and reduces the overall power consumption, thus providing a modern implementation method for neural networks in an application field that is sensitive to power, cost, and footprint. First, based on the data stream containing the training and inference process of the CNN, this study investigates methods to merge the training and inference data streams. Secondly, high-level language was used to describe the merged data stream structure, and a high-level description was converted to a hardware register transfer level (RTL) description by the high-level synthesis tool (HLS), and the intellectual property (IP) core was generated. The PS was used for overall control, data preprocessing, and result analysis, and it was then connected to the IP core via an on-chip AXI bus interface in the HA device. Finally, the integrated implementation method was tested and validated with the Xilinx HA device, and the MNIST handwritten digit validation set was used in the tests. According to the test results, compared with using a GPU, the model trained in the HA device PL achieves the same convergence rate with only 78.04 percent training time. With a processing time of only 3.31 ms and 0.65 ms for a single frame image, an average recognition accuracy of 95.697%, and an overall power consumption of only 3.22 W @ 100 MHz, the two convolutional neural networks mentioned in this paper are suitable for deployment in lightweight domains with limited power consumption.
On the Theory of the Arrhenius-Normal Model with Applications to the Life Distribution of Lithium-Ion Batteries
Authors: Kittaneh Omar
Published: January 2023

Typically, in accelerated life testing analysis, only probability distributions possessing shape parameters are used to fit the experimental data, and many distributions with no shape parameters have been excluded, including the fundamental ones like the normal distribution, even when they are good fitters to the data. This work shows that the coefficient of variation is a replacement for the shape parameter and allows using normal distributions in this context. The work focuses on the Arrhenius-normal model as a life-stress relationship for lithium-ion (Li-ion) batteries and precisely derives the estimating equations of its accelerating parameters. Real and simulated lives of Li-ion batteries are used to validate our results.
Phenotypic Characterization and Prevalence of Carbapenemase-Producing Pseudomonas aeruginosa Isolates in Six Health Facilities in Cameroon
Authors: Djuikoue Cecile Ingrid , Djouela Djoulako Paule Dana , Same Njanjo Hélène Valérie , Kiyang Christiane Possi , Djantou Biankeu Feline Leina , Guegang Celianthe , Tchouotou Andrea Sheisley Didi , Wouambo Rodrigue Kamga , Thumamo Pokam Benjamin D. , Apalata Teke , Jeannot Katy
Published: January 2023

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen with a great ability to adapt to stress, in particular, to the selective pressure of antibiotics in the hospital environment. This pathogen constitutes a real public health concern, especially in low- and middle-income countries. In Cameroon, little is known about the drug resistance patterns of Pseudomonas aeruginosa. This study sought to determine the prevalence of Pseudomonas aeruginosa strains producing carbapenemases in six health facilities in the center, littoral, and west regions of Cameroon. An analytical cross-sectional study was conducted over a four-month period from July to October 2021. All Pseudomonas aeruginosa or suspected strains isolated from pathological products at the bacteriology laboratory of different health facilities were systematically collected and underwent a re-identification. After growing on cetrimide agar and successfully subculturing on nutrient agar, an oxidase test was performed on pure colonies, followed by biochemical identification (API 20NE system) of the bacterial suspension (0.5McFarland standard). Drug susceptibility testing for the detection of extended-spectrum beta-lactamases of overproduced inducible cephalosporinases and carbapenemases was performed according to adequate standard procedures. Of the 468 isolates collected, 347 (74.14%) were confirmed Pseudomonas aeruginosa after re-identification, of which 34.49% (120/347) produced inducible cephalosporinases (CAZR and C/TS) and 32.26% (112/347) extended-spectrum beta-lactamases. The prevalence of carbapenemase-producing P. aeruginosa (IMPR and C/TR) was 25.07% (87/347), with 17.24% (15/87) class A and 82.76% (72/87) class B. A high rate of resistance to penicillin (piperacillin: 70.58% and ticarcillin: 60.24%) was observed. We also noted a 34.49% resistance to ceftazidime, 30.22% to imipenem against 37.02% to meropenem, and 25.1% to ceftolozane/tazobactam (C/T). These strains also exhibited 79.57% resistance to quinolones and about 26% to aminoglycoside families. Multivariate analysis revealed that carbapenemase-producing Pseudomonas aeruginosa-related infections were significantly associated with hospitalization (p = 0.04), maternity (p = 0.03), surgery (p = 0.04), and intensive care wards (p = 0.04). This study highlighted a high burden of resistant strains of carbapenemase-producing Pseudomonas aeruginosa. Surveillance should be intensified to prevent the dissemination and spread of these strains.
Defining the Attributes for Modernist Urban Heritage: The Case of ‘Kaunas 1919–1939: Architecture of Optimism’
Authors: Drėmaitė Marija
Published: January 2023

The cultural heritage of modern architecture is a widely acknowledged phenomenon; however, unique urban landscapes that have witnessed a fundamental transformation in urban life in the 20th century are still underrepresented on the UNESCO World Heritage List. In this paper the built urban heritage of Kaunas city (1919–1939) is investigated as an example of a modern urban heritage site with a problematic focus on defining the attributes of urban heritage, especially when intangible heritage values are added to the tangible built heritage. In this paper the attributes of modern urban heritage are discussed on the example of “Modernist Kaunas (1919–1939): Architecture of Optimism”, the nomination dossier for the UNESCO World Heritage List. Three groups of attributes are described using historical research and later discussed by applying the method of comparative analysis. The conclusion proposes that Modernist Kaunas can fill the gap by representing Eastern European modern urbanity and enhance the understanding of the modern global city by reflecting the metropolitan aspirations in modern Europe.
Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01)
Authors: Lee Yun-Gyoo , Kang Eun Joo , Keam Bhumsuk , Choi Jin-Hyuk , Kim Jin-Soo , Park Keon Uk , Lee Kyoung Eun , Lee Keun-Wook , Kim Min Kyoung , Ahn Hee Kyung , Shin Seong Hoon , Kim Hye Ryun , Kim Sung-Bae , Kim Hyo Jung , Yun Hwan Jung
Published: January 2023

We aimed to compare treatment modalities and outcomes by gender in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). We characterized the sex-specific differences and compared the overall survival (OS) between male and female patients in a multicenter cohort of LA-HNSCC. To minimize the observed confounding, propensity score matching was utilized. The study included 445 patients; 385 (86.5%) were men and 60 (13.5%) were women. In terms of age, smoking habits, drinking habits, and primary tumor locations, there was a significant imbalance in sex before the matching. Propensity score matching yielded 60 patient pairs, with no statistical difference between the sexes in terms of their characteristics. As for the treatment strategies, there were no significant differences between the sexes before (p = 0.260) and after (p = 0.585) the propensity score matching. When comparing the survival probabilities between the sexes, OS was not significantly different in the overall (HR 1.02; 95% CI 0.59–1.76; p = 0.938) and propensity-score-matched population (HR 1.46; 95% CI 0.68–3.17; p = 0.331). These results suggest that there was no difference in prognosis by gender in the treatment modalities and outcomes of LA-HNSCC in real-world practice.
Effects of the Introduction of Modern Immunotherapy on the Outcome of Isolated Limb Perfusion for Melanoma In-Transit Metastases
Authors: Holmberg Carl-Jacob , Mattsson Jan , Olofsson Bagge Roger
Published: January 2023

Isolated limb perfusion (ILP) is an effective locoregional treatment for melanoma in-transit metastasis, but the advent of modern effective immunotherapy, such as ICI (immune checkpoint inhibitors), has changed the treatment landscape. The primary aims of this study were to compare the characteristics of the patient population receiving ILP before and after the introduction of modern systemic treatments and to assess if outcomes after ILP were influenced by previous immunotherapy treatment. A single-centre analysis of patients that underwent ILP for melanoma in-transit metastasis between 2010 and 2021 was conducted, with patients grouped and compared by treatment time period: pre-ICI era (2010–2014) and ICI era (2017–2021). 218 patients were included. Patients undergoing ILP in the ICI era were slightly older (median age 73 vs. 68 years) compared to the pre-ICI era, with no other difference found. The overall response rate (ORR) was 83% vs. 84% and the complete response (CR) rate was 52% vs. 47% for the pre-ICI era and the ICI era, respectively. For patients that had received and failed immunotherapy prior to ILP (n = 20), the ORR was 75% and the CR rate was 50%. Melanoma-specific survival has improved, with a 3-year survival rate of 54% in the pre-ICI era vs. 86% in the ICI era. The patient population undergoing ILP for in-transit melanoma is largely unchanged in the current era of effective systemic treatments. Response rates have not decreased, and prior ICI treatment did not affect response rates, making ILP still a valid treatment option for this patient group.