bluuebunny/crossref_metadata_2025 huggingface dataset:
POST EMBRYONIC DEVELOPMENT OF RED-VENTED BULBUL ( PYCNONOTUS CAFER )AS OBSERVED LOCALLY IN ATIGRE, KOLHAPUR, WESTERN MAHARASHTRA, INDIA
Authors:   Department of Zoology, Y.C.W.M.Warananagar, (Aff. Shivaji Uni , Kolhapur)., R.P. Kavane
Published: May 2023

The post embryonic development and observation of the nest-building behavior and breeding performance, parental care of the red-vented bulbul was made locally in Atigre , kolhapur at two different sites, one in between human habitation and the other in natural habitat. The male and female bird took active participation in choosing the site and nest building process. The parental care was very carefully studied in these birds. Breeding activity was observed from egg laying to first flight in the study area from 05 October 2020 to19 October 2020. Nest was constructed with in 5 to 6 days on small branch triangular area of Annona squamosa custard apple. The height of nest was 1 meter from ground. Incubation period of Red Vented Bulbul was 9 to 10 days and growth period required 14 days respectively.
STREAMLINING LAUNDRY SERVICES USING INNOVATIVE WEBSITE
Authors:   Professor, School of CS & IT, Jain Deemed-to-be-University, Bangalore-69., Manju Bargavi S.K. , Bhujanga Rao Patcha ,   Professor, Department of Commerce & Management, Jain Deemed-to-be-University, Bangalore-69., Rajeshkumar S. ,   Student, School of CS & IT, Jain Deemed-to-be-University, Bangalore-69., R. Upadhyaya Bhavyashree ,   Student, School of Commerce, Jain Deemed-to-be-University, Bangalore-69., Gowda C. Sumanth ,   Student,School of CS & IT, Jain Deemed-to-be-University, Bangalore-69., Kumar Kundan ,   Student,School of CS & IT, Jain Deemed-to-be-University, Bangalore-69., Kumar C. Girish ,   Student,School of CS & IT, Jain Deemed-to-be-University, Bangalore-69., Srivastava Mansi ,   Student,School of CS & IT, Jain Deemed-to-be-University, Bangalore-69.
Published: May 2023

Laundry as a notion has changed over time. Laundry services and subsequently washing machines have supplanted the practice of doing our own laundry. Thus, much clever labor has taken the place of much hard work. Laundry stores, which greatly decreased the amount of laundry people had to do at home back then, were where the idea and development of laundry first began. which actually led to greater labour and energy savings. Based on current Internet technology advancements, laundry will evolve, and its clever work will become better and more effective as a website known as The Laundry Management. This will happen due to the fast use of online portals and other sites. It will also make a few suggestions to help this idea succeed. The data is gathered solely from secondary sources, i.e., through a review of literature, and thus it is a philosophical study.
MALE BREAST ULCERATION REVEALING BREAST CARCINOMA: CASE REPORT
Authors:   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Oualla Jamila , Marghadi Hajar ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Bennour Bouchra ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Mansouri Nabil ,   Department of Pathology, Universitary Hospital, Marrakech, Morocco., Aboudourib Maryem ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Hocar Ouafa ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech., Amal Said ,   Department of Dermatology, Biosciences and Health Laboratory, Faculty of Medicine and Pharmacy of Marrakech.
Published: May 2023

Breast cancer in men is rare, poorly known by the general population, the breast lesion is often neglected, the patient consults only at an advanced stage of evolution with significant local extension and even secondary localization of metastases. we report the case of a 65 year old patient, who consulted late after 3 years of evolution for an ulceration of the right breast revealing a breast carcinoma with lymph node, pulmonary and bone metastases. this case shows the interest to sensitize the general population on the existence of breast cancer in men as well as women, and the importance of self-examination and early consultation for any abnormal lesion of the breast.
A COMPARATIVE STUDY OF INJECTION DICLOFENAC SODIUM VERSUS INJECTION PARACETAMOL INFUSION AS POST-OPERATIVE ANALGESIA IN LAPAROSCOPIC ABDOMINAL SURGERIES UNDER GENERAL ANAESTHESIA
Authors:   Student, SBKS Medical Institute and Research Center, Piparia, Vadodara., Patel Meshwa , Patel Jatin ,   Professor, Department of Anaesthesiology, SBKS Medical Institute and Research Center.
Published: May 2023

Post operative pain is acommon symptom causing post-operative psychological stress and anxiety leading to physiological effects. This research paper compares the analgesic effect of IV Diclofenac Sodium versus IV Paracetamol infusion in post operative period following laparoscopic abdominal surgeries. Patients are divided into 2 groups and observations are made with regards to the duration of analgesia and drug related post opertaive complications in both these groups.
PAPILLARY FIBROELASTOMA : A CASE REPORT AND REVIEW OF THE LITERATURE
Authors:   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco., K. Raissouni , N. Rguieg ,   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco., M. Azzakhmam ,   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco., M.A Essaoudi ,   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco., M. El-Ochi ,   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco., M. Allaoui ,   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco., A. Damiri ,   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco., H. Chahdi ,   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco., A.H Ktaibi ,   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco., M. Oukabli ,   Department of Pathology, Military Hospital Mohammad V, Rabat, Morocco.
Published: May 2023

Papillary fibroelastoma (PFEs) is a rare primary benign cardiac tumour which can cause severe embolic complications. We report the case of a 44-year-old with a sessile masse adhering to the aortic valve objectified by a transthoracic echocardiography. This mass was excised surgically and analysed histologically. The diagnosis of papillary fibroelastoma was then confirmed.
SECURE FILE STORAGE ON CLOUD USING HYBRID CRYPTOGRAPHY
Authors:   Department of CSE CTIS, Faculty of Engineering and Technology, JAIN (Deemed-to-be-University) Karnataka 562112, India., Satheesh Kumar Ashwin , K. Anfah ,   Department of CSE CTIS, Faculty of Engineering and Technology, JAIN (Deemed-to-be-University) Karnataka 562112, India., T. Hariharan ,   Department of CSE CTIS, Faculty of Engineering and Technology, JAIN (Deemed-to-be-University) Karnataka 562112, India., Parveen Rosna ,   Department of CSE CTIS, Faculty of Engineering and Technology, JAIN (Deemed-to-be-University) Karnataka 562112, India., Mahmud Sizan ,   Department of CSE CTIS, Faculty of Engineering and Technology, JAIN (Deemed-to-be-University) Karnataka 562112, India., Sharma Sonal ,   Department of CSE CTIS, Faculty of Engineering and Technology, JAIN (Deemed-to-be-University) Karnataka 562112, India.,   Associate Professor School of CSE.
Published: May 2023

Our project aims to provide secure file storage for users on the cloud (specifically on AWS S3) by utilizing a hybrid cryptography approach. This involves encrypting files using both AES and RSA algorithms, with the user receiving the encryption key through email. To further enhance security, the key will be hidden behind an image or within a PDF document using steganography techniques. Additionally, the files stored in the S3 bucket will also be encrypted, but instead of encrypting the contents of the file, we will encrypt the file format itself. The file format can be decrypted using the GHE decryption key and software, which will be made available to end-users. Overall, our project aims to provide a robust and secure solution for cloud-based file storage.
RISK FACTORS AFFECTING SEVERITY OF INTRAVENTRICULAR HEMORRHAGE IN PRETERM INFANTS OF AN NICU OF A TERTIARY CARE CENTRE
Authors: Garg Shatakshi , Chakraborty Pallav , Tikhe Isha , Valvi Chhaya
Published: May 2023

Background: As severe germinal matrix intraventricular haemorrhage (GM-IVH) causes neurological sequelae in 50â€“75% of preterm survivors, it is still a major global public health problem. [1].By studying the association and severity with risk factors for IVH in preterms we can make preventive measures for the same. Objective: The purpose of this study is to identify the risk factors associated with the development IVH in the preterm infants of an NICU of a tertiary care centre and the relationship of the severity of disease and these risk factors. Methods: It is a retrospective study. A total of 160 premature neonates of gestational age â‰¤34 weeks were examined by cranial ultrasound (CUS) for detection of GM-IVH among the babies admitted in neonatal intensive care unit of a tertiary teaching hospital at Pune, Maharashtra. The babies were divided into two groups: GM-IVH and non-IVH. The association and severity of neonatal and maternal risk factors were analysed. Results: In our study, out of 160 neonates, 75 neonates (46.8%) developed intraventricular haemorrhage, of which 8% developed severe IVH (grade 3 and 4). Use of inotropes (pâ€‰=â€‰0.008), surfactant (pâ€‰<â€‰0.0001), blood transfusions(p=0.005),HsPDA(p=0.006) were highly significant for developing intraventricular haemorrhage. Conclusions: Clinicians and healthcare policy makers should consider these factors during decision-making coverage of (complete) antenatal steroid therapy, early diagnosis and treatment of PDA with paracetamol/ibuprofen, delayed cord clamping in labour room to prevent hypotension hence, use of inotropes and boluses can prevent GM-IVH in preterms.
BILATERAL BREAST METASTASES OF RECTAL ADENOCARCINOMA: CASE REPORT AND REVIEW OF THE LITERATURE
Authors:   Radiation Oncology Department, Oncology Hospital, Hassan II University Hospital, Fes, Morocco., Soussy Kaoutar , Dabir Yassine ,   Radiation Oncology Department, Oncology Hospital, Hassan II University Hospital, Fes, Morocco., Slassi Noureddine ,   Medical Physics Unit, Hassan II University Hospital, Fes, Morocco., Ait Erraisse Mohammed ,   Radiation Oncology Department, Oncology Hospital, Hassan II University Hospital, Fes, Morocco., Hassani Wissal ,   Radiation Oncology Department, Oncology Hospital, Hassan II University Hospital, Fes, Morocco., Zahra Farhane Fatima ,   Radiation Oncology Department, Oncology Hospital, Hassan II University Hospital, Fes, Morocco., Alami Zenab ,   Radiation Oncology Department, Oncology Hospital, Hassan II University Hospital, Fes, Morocco., Bouhafa Touria ,   Radiation Oncology Department, Oncology Hospital, Hassan II University Hospital, Fes, Morocco.
Published: May 2023

Breast metastasis from extramammary neoplasm is rare and with poor prognosis. A 25-year-old patient presented with a lump in her right breastthree months after concurrent chemoradiotherapy for an IIc stage rectal adenocarcinoma (T4bN0M0) and during her neoadjuvant chemotherapy with FOLFOX. The investigationsconfirmeda bilateral breast metastasis of rectal adenocarcinoma.
REVIEW ARTICLE ON (3Î’,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIEN-3-OL (CHOLECALCIFEROL)
Authors:   Department of Pharmacology and Toxicology, Accuprec Research Labs Pvt Ltd, Opp. ZydusPharmez, Changodar - Bavla Highway, Ahmedabad, Gujarat 382213., R. Raval Ritu
Published: May 2023

Vitamin D called as sunshine. There are varieties of sources available for cholecalciferol but mainly dairy, sea food and synthesized products are used. Calcitriol deficiency increased now days due to imbalanced life cycle and some desired and undesired effects of medications. We discuss about calcitriol life cycle from UV rays to immersion in the body as 7-Dehydrocholesterol to calcitriol. There are some parameters which effects on calcitriol absorption like age, skin color, disease, medications etc and discussed how to overcome calcium deficiency.
SURGICAL REMOVAL OF SUPERNUMERARY TOOTH FOLLOWED BY ORTHODONTIC TRACTION OF PERMANENT CENTRAL INCISOR BY FIXED APPLIANCE THERAPY
Authors: Koundal Lisma , Priyanka Kumari
Published: May 2023

Management of immature root with a necrotic pulp and apical periodontitis is a challenging task. Obturation of the root canal is difficult because of lack of apical barrier for containing the root filling material. Treatment of choice in such cases is the apexification procedure, i.e., establishing an apical barrier. Calcium hydroxide has been widely used for the induction of hard tissue barrier. However, this material requires 5-20 months to form the hard tissue barrier. It has also been shown that the use of calcium hydroxide weakens the resistance of the dentin to fracture. In recent times, mineral trioxide aggregate (MTA) has gained widespread popularity for the apexification procedure. It produces apical hard tissue formation with significantly greater consistency than calcium hydroxide.MTA, a biocompatible material, can be used to create a physical barrier. It also helps in the formation of bone and periodontium around its interface.
ASSESSMENT OF MAGNITUDE AND RISK CORRELATES OF DEPRESSION & ANXIETY SYMPTOMS AMONG SCHOOL GOING ADOLESCENTS IN MUMBAI SUBURBAN AREA, INDIA
Authors:   Senior Resident, Department of Community Medicine, HBTMC and Dr RN Cooper Hospital Mumbai., Qureshi Saniya , Qureshi Kamran ,   Assistant Professor, Department of Community Medicine, HBTMC and Dr RN Cooper Hospital Mumbai., Chavhan Smita ,   Associate Professor, Department of Community Medicine, HBTMC and Dr RN Cooper Hospital Mumbai.
Published: May 2023

Introduction: In India, Depression & anxiety symptoms are considered Diseases of adulthood. Just like other non-communicable diseases, mental disorders are emerging as Hidden killers, it is important to screen these diseases since adolescence. Objectives: to assess the magnitude of depression & anxiety symptoms and their risk factors. Methods: A crossâ€‘sectional study was conducted among 175 adolescents enrolled in 8th â€“ 10th standards in private school of Mumbai suburban area using the modified PHQ-9 & GAD-7 binary logistic regression was applied to find significant risk correlates. Results:Mean age was 13.95Â±0.97years and 53.1 % were females. Depression was found in 24 % anxiety symptoms in 23% adolescents. On logistic regression, depression and anxiety symptoms was associated with female gender [OR: 3.072 & OR: 2.925] family members â‰¤ 5 [OR: 2.182 & OR: 1.502] and not willing to come to school [OR: 6.43 & OR: 5.42]. Conclusion: The level of depression & anxiety symptoms was higher among female gender, having family member â‰¤ 5 & those who were not willing to come to school. Less fights with parents, no failure in examinations, ability to cope up with academics, having normal sleep pattern, never faced teasing & bullying by fellow students had lower chances of having depression & anxiety symptoms.Anxiety and depression are major public health problems among adolescents. The high burden estimated in our study highlights the need for immediate action to support school going adolescents.
ASSESSING THE EFFECTIVENESS OF FISHERIES COURTS IN INDONESIA
Authors:   University of Lampung, Department of Law, Lecturer and Doctoral Student in Law., Shafira Maya , Akib Muhammad ,   University of Lampung, Department of Law, Lecturer., Rifai Eddy ,   University of Lampung, Department of Law, Lecturer.
Published: May 2023

This article aims to provide comparison viewed from the economic and law enforcement aspect prior to and following the establishment of Special Fisheries Courts. This study combines two methods of research, namely research on normative laws and supported by an empirical study of the law using various sources of data. Data collection was was conducted by document search and in-depth interviews The findings of this research indicate that Special Fisheries Courts play a rather significant role in the economic improvement of the fisheries sector. However, viewed from the aspect of law enforcement, there has been an increase in crime in the fisheries sector after the establishment of Special Fisheries Courts. Based on the findings and discussion it is concluded that Special Fisheries Courts are yet to be effective in prosecuting criminal acts in the fisheries sector. The limitations and contribution of this research forward to proposes several strategies namely the establishment of Special Fisheries Courts in all areas prone to illegal fishing, extending the jurisdiction of ad hoc judges, and appointing ad hoc judges at the appeals and cassation level.
The Victimological Context on Child Sexual Violence
Authors: Chasanah Anissaa Nuril , Arifin Ridwan
Published: May 2023

Sexual violence against children is a crime that needs serious attention. In this crime, children as victims often do not get adequate legal protection and fulfill their rights as victims. This study aims to analyze child sexual crimes in the context of victimology and victim protection. This study uses a normative legal study approach by analyzing the applicable laws and regulations as well as literature review related to the protection of children as victims of sexual crimes. This study proves and confirms that the protection of children in cases of sexual crimes has been legally guaranteed through the Law on the Protection of Witnesses and Victims, the Law on Child Protection, and the Law on Human Rights. However, the process of fulfilling the rights of children as victims in these crimes does not yet have adequate aspects of justice for children. The existing criminal law instruments are only oriented towards punishment and deterrence of perpetrators of sexual crimes. Kekerasan seksual terhadap anak menjadi salah satu tindak pidana yang perlu mendapatkan perhatian serius. Pada tindak pidana ini, anak sebagai korban seringkali tidak mendapatkan perlindungan hukum dan pemenuhan hak-haknya sebagai korban secara memadai. Studi ini bertujuan untuk menganalisis kejahatan seksual anak dalam konteks viktimologi dan perlindungan korban. Studi ini menggunakan pendekatan studi hukum normatif dengan menganalisis aturan perundang-undangan yang berlaku serta kajian kepustakaan berkaitan dengan perlindungan anak sebagai korban kejahatan seksual. Studi ini membuktikan dan menegaskan bahwa perlindungan anak dalam kasus kejahatan seksual telah dijamin secara yuridis melalui Undang-Undang Perlindungan Saksi dan Korban, Undang-Undang Perlindungan Anak, dan Undang-Undang Hak Asasi Manusia. Namun demikian proses pemenuhan hak-hak anak sebagai korban dalam tindak pidana tersebut belum memiliki aspek keadilan yang memadai bagi anak. Instrumen hukum pidana yang ada hanya berorientasi terhadap pemidanaan dan penjeraan terhadap pelaku kejahatan seksual.
Подвиги девушек-санитарок в годы войны 1941-1945 гг.: по материалам биографии лаборанта кафедры анатомии КГМИ А.И. Вовк
Authors: Харченко В.В. , Рязаева Л.М. , Никишина Н.А. , Лапшина А.А.
Published: May 2023

Настоящая статья — это часть большого проекта сотрудников Курского государственного медицинского университете по увековечиванию памяти сотрудников прошлых лет, принимавших участие в Гражданской войне и/или Великой Отечественной войне 1941-1945 гг. Цель настоящей статьи – предоставить возможность студентам и сотрудникам университета познакомиться с биографией и наградами военных лет лаборанта кафедры анатомии человека, Александры Ильиничны Вовк. Актуальность настоящего исследования заключается в необходимости гражданско-патриотического воспитания студентов, одним из средств которого является поисковая и историко-краеведческая работа в процессе знакомства с историей становления и развития Курского государственного медицинского университета.
Взаимосвязь психологического благополучия и ценностных ориентаций личности
Authors: Музыченко А.В. , Харитончик А.А.
Published: May 2023

В статье представлены результаты исследования взаимосвязи психологического благополучия и ценностных ориентаций личности. Результаты исследования показали, что в выборке средней взрослости у специалистов, работающих с применением компьютерных технологий, отсутствуют различия между уровнем нормативных идеалов и уровнем социальных приоритетов. Эти специалисты в повседневной жизни стараются придерживаться своих взглядов и убеждений, а не идти на поводу у социального окружения. Половина исследуемой выборки имеет высокие показатели позитивных отношений, средние показатели личностного роста, достаточно высокие показатели самопринятия. Самым высоким в выборке является показатель автономии, что утверждает личностную зрелость в анализируемый возрастной период. Почти половина работников имеют высокий уровень психологического благополучия, что отражает удовлетворительное качество межличностных отношений и достижений.
Application of non-parametric approaches to identify trends in streamflow for the Mae Klong River Basin, Thailand
Authors: Khalil Alamgir
Published: May 2023

Mean monthly streamflow records of ten gauging stations in the Mae Klong River Basin, Thailand, were analyzed for trends using non-parametric approaches for the period 2000–2015. The statistical significance of trends was tested on monthly, seasonal, and annual scales using three non-parametric tests; Mann–Kendall (MK), Spearman's rho (SR), and innovative trend analysis (ITA) on a 5% significance level. The streamflow stations were grouped into two categories: naturalized streamflow (four stations) and regulated streamflow (six stations). In both the dry and wet seasons, decreasing trends were observed in the naturalized inflows to the Srinagarind and Vajiralongkorn Dams. On an annual basis, all the naturalized streamflow stations showed decreasing trends. For the regulated streamflow stations, in the dry season, four out of six stations showed increasing trends, while in the wet season, five out of six stations indicated decreasing trends. On an annual basis, five stations showed decreasing trends by both the MK and SR tests, while the ITA method indicated decreasing trends for four regulated streamflow stations. The results of this study can help water resources managers for better assessment and planning of water resources in the basin.
Essential Trace Elements in Patients with Dyslipidemia: A
Meta-analysis
Authors: Li Cui-Ping , Song Yu-Xin , Lin Zi-Jun , Ma Mei-Lin , He Lian-Ping
Published: May 2023

Background:

Lipid metabolism is a complex process that includes lipid uptake,
transport, synthesis, and degradation. Trace elements are vital in maintaining normal
lipid metabolism in the human body. This study explores the relationship between
serum trace elements and lipid metabolism.Lipid metabolism is a complex process that includes lipid uptake,
transport, synthesis, and degradation. Trace elements are vital in maintaining normal
lipid metabolism in the human body. This study explores the relationship between
serum trace elements and lipid metabolism.

Methods:

In this study, we reviewed articles on the relationship between alterations in somatic
levels of zinc, iron, calcium, copper, chrome, manganese, selenium, and lipid
metabolism. In this systematic review and mate-analysis, databases such as PubMed,
Web of Science, and China National Knowledge Infrastructure (CNKI), Wanfang was
searched for articles on the relationship published between January 1, 1900, and July 12,
2022. The meta-analysis was performed using Review Manager5.3 (Cochrane Collaboration).

Results:

No significant association was found between serum zinc and dyslipidemia,
while other serum trace elements (iron, selenium, copper, chromium, and manganese)
were associated with hyperlipidemia.

Conclusion:

The present study suggested that the human body's zinc, copper, and calcium
content may be related to lipid metabolism. However, findings on lipid metabolism
and Iron, Manganese have not been conclusive. In addition, the relationship between
lipid metabolism disorders and selenium levels still needs to be further studied. Further
research is needed on treating lipid metabolism diseases by changing trace elements.
A Review on Artificial Intelligence Approaches and Rational Approaches in Drug
Discovery
Authors: Srivathsa Anjana Vidya , Sadashivappa Nandini Markuli , Hegde Apeksha Krishnamurthy , Radha Srimathi , Mahesh Agasa Ramu , Ammunje Damodar Nayak , Sen Debanjan , Theivendren Panneerselvam , Govindaraj Saravanan , Kunjiappan Selvaraj , Pavadai Parasuraman
Published: May 2023

Artificial intelligence (AI) speeds up the drug development process and reduces its time, as well as
the cost which is of enormous importance in outbreaks such as COVID-19. It uses a set of machine learning algorithms
that collects the available data from resources, categorises, processes and develops novel learning
methodologies. Virtual screening is a successful application of AI, which is used in screening huge drug-like
databases and filtering to a small number of compounds. The brain’s thinking of AI is its neural networking
which uses techniques such as Convoluted Neural Network (CNN), Recursive Neural Network (RNN) or Generative
Adversial Neural Network (GANN). The application ranges from small molecule drug discovery to the
development of vaccines. In the present review article, we discussed various techniques of drug design, structure
and ligand-based, pharmacokinetics and toxicity prediction using AI. The rapid phase of discovery is the
need of the hour and AI is a targeted approach to achieve this.
Folate Targeting Peptide Conjugates for Inflammatory Response Suppression
Authors: Ruff Elizabeth , Poh Scott
Published: May 2023

Background and Objective:

Protein kinases known as mitogen-activated protein kinases (MAPKs) are
responsible for regulating a wide variety of physiological cell responses by generating and release of inflammatory
mediators. Suppressing these inflammatory mediators can be utilized to control the propagation of inflammation.
During the course of this research, we created folate-targeted MK2 inhibitor conjugates and analyzed the antiinflammatory
effects of these compounds.

Methods:

Using RAW264.7 cells, which are generated from murine macrophages, as an in vitro model. We synthesize
and evaluated a folate linked peptide MK2 inhibitor. The cytotoxicity was assessed using the ELISA kits, CCK-
8 test kit, NO concentration and inflammatory factors TNF-, IL-1, and IL-6.

Results:

The cytotoxicity assay results suggested that the concentration for MK2 inhibitors less than 50.0 μM be
non-toxic. The ELISA Kits also demonstrated that MK2 peptide inhibitor treatment significantly decreased the content
of NO, TNF-, IL-1, and IL-6 in LPS-stimulated RAW264.7 cells. It was also demonstrated that a folate-targeted
MK2 inhibitor was more effective than a non-targeted inhibitor.

Conclusion:

This experiment demonstrates that LPS-induced macrophages can produce oxidative stress and inflammatory
mediators. According to our research, pro-inflammatory mediators can be reduced by targeting folate receptor-
positive (FR+) macrophages with an FR-linked anti-inflammatory MK2 peptide inhibitor in vitro, and the uptake
was FR-specific.
Smoking Affects the Predictive Roles of Antioxidant Enzymes in the
Clinical Response to Risperidone in Schizophrenia: A Large-scale Cohort
Study
Authors: Xiu Meihong , Song Xiuli , Yang Hanlun , Huang Xingjuan , Wu Fengchun , Zhang Xiangyang
Published: May 2023

Objectives:

There is overwhelming evidence of the relationship between smoking and
schizophrenia (SZ). Tobacco smoke is considered to ameliorate the symptoms and reduce the side effects
of antipsychotics in SZ patients. However, the underlying biological mechanism by which tobacco
smoke improves symptoms in SZ remains unclear. This study was designed to examine the effects
of tobacco smoke on antioxidant enzyme activities and psychiatric symptoms after receiving 12-week
risperidone monotherapy.

Methods:

Two hundred and fifteen antipsychotic-naïve first-episode (ANFE) patients were recruited
and treated with risperidone for 3 months. The severity of the patient’s symptoms was assessed by the
Positive and Negative Syndrome Scale (PANSS) at baseline and at post-treatment. Plasma SOD,
GSH-Px, and CAT activities were determined at baseline and follow-up.

Results:

Relative to nonsmoking patients with ANFE SZ, patients who smoked had higher baseline
CAT activity. In addition, among non-smokers with SZ, baseline GSH-Px was associated with clinical
symptom improvement, while baseline CAT was associated with positive symptom improvement in
smokers with SZ.

Conclusion:

Our findings demonstrate that smoking affects the predictive role of baseline SOD, GSHPx,
and CAT activities on clinical symptom improvement in patients with SZ.
WITHDRAWN: Long-term Survival Analysis of 30 Maintenance Hemodialysis
Patients with HIV Infection in a Single-center in China
Authors: Gao Guiju , Ren Wenwen , Fang Yajuan , Wang Tongtong , Zhu Chunyu , Xiao Jiang , Wang Fang , Ni Liang , Yang Di
Published: May 2023

The article has been withdrawn at the request of the author of the journal Current HIV Research (CHIVR).

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

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Catalytic One-pot Solvent Free Synthesis, Biological Activity, and Docking
Study of New Series of 1, 3-thiazolidine-4-one Derivatives Derived from 2-
(P-tolyl) Benzoxazol-5-amine
Authors: Khudhur Hussein Kaka Ahmed , Hussein Awaz Jamil
Published: May 2023

Objective:

In this study, a simple triethylammonium salt of phosphoric acid (tri-ethylammonium dihydrogen phosphate) (4) in the liquid state was utilized as an inexpensive, effi-cient one-pot three components, solvent-free synthesis of thiazolidine-4-one derivatives, with good to excellent yields. Techniques such as FT-IR, 1H-NMR, 13C-NMR, 13C-NMR-DEPT-135, and MS. were used for the structural elucidation. The high biotic efficiency of the newly obtained compounds was confirmed by in vitro antimicrobial action against Gram-positive (S. Aureus), Gram-negative bacteria (P. Aeruginosa and E. Coli) and antifungal activity (C. Albicans) via mi-croplate titer dilution technique. Finally, a molecular docking study was performed with a re-solved crystal structure of S. Aureus D-alanine alanyl carrier protein ligase (PDB ID: 7VHV). This investigation aimed to synthesize a new series of thiazolidine-4-one derivatives combined with benzoxazole moiety.

Materials and Methods:

Ionic liquid assistance one-pot solvent-free synthesis method used to synthesize a new series of thiazolidine-4-one derivative 10(a-e).

Results:

Structural identification of new synthesis and biological evaluation via techniques of (IR, 1H-NMR, 13C-NMR, 13C-NMR-DEPT-135, and MS).

Conclusion:

Ionic liquid is utilized as an inexpensive, efficient one-pot three-component solventfree
synthesis of thiazolidine-4-one derivatives with good to excellent yields.

:

Most of the synthesized compounds showed high biological and anti-fungal activity, in line with
the docking study against mentioned microorganism and crystal structure of PDB (ID: 7VHV), respectively.
Design and In-silico Screening of Short Antimicrobial Peptides (AMPs) as
Anti-Tubercular Agents Targeting INHA
Authors: Mehta Kanchan , Vyas Pallavi , Mujawar Shama , Hazam Prakash Kishore , Vyas Ashish
Published: May 2023

Introduction:

Tuberculosis has been studied as a potentially serious bacterial infection affecting
the lung caused by Mycobacterium tuberculosis. In addition to its severe impact on health, resistance
to existing drugs has also been seen as a rising concern in the space of medicinal solutions.
Therapeutic peptides have the potential to complement existing drug designs to provide effective outcomes
against Mycobacterium tuberculosis-resistant strains.

Methods:

This study illustrated a computational approach to design and test peptides against NADHdependent
enoyl-acyl carrier protein reductase of Mycobacterium tuberculosis. A human antimicrobial
peptide LL-37 was used as a template, and a further 6 peptides were designed, and their binding and interactions
against NADH-dependent enoyl-acyl carrier protein reductase were examined. Further, toxicity,
immunogenicity, and a broad spectrum of physicochemical properties were calculated to evaluate
the therapeutic and safety profile of these peptides.

Results:

These peptides were structurally modelled and docked with the protein to determine their binding
poses and affinity. The molecular interaction of LL-37 with protein was treated as a reference to
evaluate the effectiveness of designed peptides. Solvent accessible surface area (SASA) and ΔG binding
free energy of docked complexes assisted in the ranking of these peptides. Eventually, peptides P1:
LLGDFFRKSKEK, P3: LLFGDRFLLKEK and P7: LLGDFFRLLKEK were selected for 100 ns molecular
dynamic simulation as they showed predicted dissociation constants of 8.7×10-4 M, 3.3×10-4 M
and 1.2×10-4 M, respectively. These peptides showed direct hydrogen bond formation with ILE21 and
LYS165, which are critical active site residues of the protein. The structural variation pattern collected
from the MD simulation suggested a strong and stable binding of P3 and P1 with the protein with
RMSD 4-5 Å with the starting conformation under the non-fluctuating state. These two peptides showed
relatively similar binding results compared with the control peptide LL-37. Comprehensive structural
analysis was performed for the middle structures of the most populated cluster generated from 100 ns
MD simulation trajectory.

Conclusion:

Later, MMPBSA binding energies of these structures were computed, where the average
binding free energies of P1, P3, and P7 peptides were -146.93 kcal/mole, -161.16 kcal/mole, and -
151.44 kcal/mole, respectively. These energies suggested that P3 is strongly bound to the active site of
NADH-dependent enoyl-acyl carrier protein reductase. Overall, this study proposed the application of
these peptides as a possible therapeutic solution to inhibit the growth of Mycobacterium tuberculosis.
Anti-inflammatory Activity: In silico and In vivo of Sapogenins Present in Agave brittoniana subsp. brachypus (Trel.)
Authors: Resino-Ruiz Dayana , Gonzalez-Madariaga Yisel , Nieto Leisy , Linares Yilka Mena , Guerra León Jose Orestes , Martín Arlena Vázquez , Díaz Arianna Valido , Torrens Francisco , Castillo-Garit Juan A.
Published: May 2023

Background:

Agave brittoniana subsp. brachypus is an endemic plant of Cuba, which contains different steroidal sapogenins with anti-inflammatory effects. This work aims to develop computational models which allow the identification of new chemical compounds with potential anti-inflammatory activity.

Methods:

The in vivo anti-inflammatory activity was evaluated in two rat models: carrageenan-induced paw edema and cotton pellet-induced granuloma. In each study, we used 30 Sprague Dawley male rats divided into five groups containing six animals. The products isolated and administrated were fraction rich in yuccagenin and sapogenins crude.

Results:

The obtained model, based on a classification tree, showed an accuracy value of 86.97% for the training set. Seven compounds (saponins and sapogenins) were identified as potential anti-inflammatory agents in the virtual screening. According to in vivo studies, the yuccagenin-rich fraction was the greater inhibitor of the evaluated product from Agave.

Conclusion:

The evaluated metabolites of the Agave brittoniana subsp. Brachypus showed an interesting anti-inflammatory effect.
Clinical Dilemma, Bernard Soulier Syndrome versus Immune Thrombocytopenic
Purpura: A Case Report
Authors: J Bhavya , Patel Nitish Kumar , Kumar Nilesh , Singh Jitendra , Kumar Kailash
Published: May 2023

Background:

Bernard Soulier Syndrome (BSS) is a rare autosomal recessive disorder due
to deficiency or dysfunction of the glycoprotein GPIb-V-IX complex on the platelet surface. It is
also known as hemorrhagiparous thrombocytic dystrophy or congenital hemorrhagiparous thrombocytic
dystrophy. The patient usually presents with severe and prolonged bleeding along with characteristics
of giant blood platelets and low platelet counts. Manifestations of BSS include epistaxis,
gum bleeding, purpuric rashes, menorrhagia, rarely melena, and hematemesis. On the other hand,
immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder in which there is accelerated
platelet destruction and reduced platelet production. Isolated thrombocytopenia without
fever, lymphadenopathy, and organomegaly usually lead to the diagnosis of immune thrombocytopenia.

Case Presentation:

A 20 years old female presented with complaints of recurrent episodes of epistaxis
since childhood and menorrhagia during menarche. She was misdiagnosed as ITP elsewhere.
Later, based on thorough clinical examination and investigation, the diagnosis was confirmed as
BSS.

Conclusion:

BSS should always be taken in the differential diagnosis of ITP, especially when persistent,
refractory, and treated unsuccessfully with steroids or splenectomy.
The Effect of the Seed of Descurainia Sophia on Functional Constipation
in Iranian Women Aged 50-70 Years: A Randomized Controlled Trial
Authors: Tabatabaeichehr Mahbubeh , Mortazavi Hamed , Pournaghi Seyed-Javad , Kasaian Jamal , Yaaghoobian Barmak , Akbari Hadi , Kheivegi Neda , Alesheikh Peiman
Published: May 2023

Background:

Constipation in older adults is a common issue and is more prevalent in
women. The current study aimed to assess the effectiveness of the seed of Descurainia Sophia as
an herbal medicine on the severity of constipation in older women.

Methods:

Total, sixty-four women aged between 50 to 70 participated in the study. The study used
a randomized controlled trial to investigate the effectiveness of the seed of Descurainia Sophia on
constipation. Data were collected using a constipation assessment scale and analyzed using independent
samples t-test and gain score procedure.

Results:

It was shown that taking a mixture of water and seeds of Descurainia Sophia significantly
reduces constipation severity in older women.

Conclusion:

It was concluded that the seed of Descurainia Sophia is a safe and effective alternative
for treating constipation in older women.
Preparation of Encapsulated Turmeric Extract for Food Fortification
Authors: Uslu Mehmet Emin , Öder Gizem , Bayraktar Oguz
Published: May 2023

Introduction:

Cross-linked alginate beads containing turmeric extract were produced using the electrospraying method to achieve the release of bioactive compounds in a sustained manner.

Methods:

An aqueous alginate solution containing turmeric extract was electrosprayed into an aqueous phase containing a crosslinking agent (calcium chloride) at different process variables (alginate concentrations, flow rates and voltages). Then, particle size and distribution were investigated with an optical microscope.

Results:

Prepared alginate beads with 1 wt % alginate concentration, 20 kV and 1 ml/h exhibited the desired beads with turmeric extract content. Alginate beads containing turmeric extract were kept in water for 72 hours and total amount of antioxidant and total amount of phenol which was released to liquid were investigated. Afterwards, solution with alginate beads were centrifuged and dried to observe structural changes. Total antioxidant activity and total phenol in the dried beads were studied. Some samples released most amount of antioxidants and phenol to the medium. Similarly, some samples kept all antioxidants and phenol.

Conclusion:

In conclusion, electroencapsulation can be used in food applications in order to con-serve the bioactivity of active compounds.
PEMBUATAN ASAP CAIR DARI KULIT KOPI (Coffea sp.) DAN APLIKASINYA SEBAGAI KOAGULAN LATEKS
Authors: Agus Triawan Deni , Nurwidiyani Ria , Nesbah Nesbah , Sarsiwi Hamurwani Dyah , Alika Puteri Noza , Vintanta Nasution Alemina , Yuliyani Utami
Published: May 2023

Pengolahan kopi (Coffea sp.) melalui penggilingan akan menghasilkan limbah kulit kopi yang tidak termanfaatkan dan hanya ditumpuk di sekitar lokasi pengolahan. Kulit kopi (Coffea sp.) mengandung lignin dan selulosa yang dapat dimanfaatkan sebagai bahan pembuatan asap cair. Asap cair memiliki beberapa kegunaan diantaranya dapat diaplikasikan sebagai koagulan karet alam (lateks). Asap cair dihasilkan melalui proses pirolisis selama 6 jam dengan suhu ± 350◦C. Rendemen asap cair yang dihasilkan dari proses pirolisis kulit kopi sebesar 19,6% dengan karakteristik berbau asap, berwarna coklat kemerahan dengan berat jenis sebesar 1,007 ± 0,003 gr/mL, pH 3,62 ± 0,021, dan kadar asam total 9,75 ± 0,025%. Analisis menggunakan spektrofotometer FTIR menunjukkan adanya vibrasi gugus –OH, C=O dan C-O yang diduga berasal dari gugus karboksilat. Asap cair diaplikasikan sebagai koagulan lateks dengan konsentrasi (dalam v/v) yaitu 5%, 10%, 15%, dan 20% serta lateks murni tanpa perlakuan sebagai kontrol negatif dan asam formiat 2% (v/v) sebagai kontrol positif. Pada konsentrasi asap cair 15% waktu koagulasi lateks menunjukkan hasil yang hampir sama dengan penggunaan asam formiat 2%. Pada konsentrasi asap cair yang lebih tinggi yaitu 20% (v/v), proses koagulasi menggunakan asap cair lebih cepat dibandingkan dengan asam formiat 2% (v/v). Penggunaan asap cair dari kulit kopi pada proses koagulasi lateks mampu memperpendek waktu koagulasi serta menghilangkan bau busuk pada lateks namun mengubah warna lateks alami menjadi abu-abu. Berdasarkan hasil penelitian tersebut asap cair kulit kopi (Coffea sp.) dapat digunakan sebagai koagulan lateks untuk menggantikan asam formiat.
Revitalizing the Branding of Tegal City As the Japanese of Indonesia
Authors: Sutjiatmi Sri , Supriyanto Eko Eddya , Suparto Diryo , Rachmawati Meida
Published: May 2023

The researchers are revitalizing the branding of Tegal City as the Japanese of Indonesia through strengthening metal industrialization by networking with the manufacturing industry. This policy was carried out because of the potential for a home industry-based metal industry. This potential can undoubtedly become a brand that has long been owned by Tegal City but needs more touch and attention from the government. The researchers adopted a dual case study strategy with an exploratory qualitative approach as our research strategy. The discussion obtained from this research is the need for a link and match between the home metal and manufacturing industries. Even though there has been direct contact, the productivity of the home metal industry could have been better. In conclusion, we are revitalizing the branding of Tegal city as Japan Indonesia requires an injection of investors, quality human resource training to meet the demands of the manufacturing industry, and modernization of machines to increase the productivity of the home metal industry players.
Las sanciones en el Sistema de Responsabilidad Penal Adolescente en Colombia
Authors: Torres-Vásquez Henry , Tirado-Acero Misael
Published: May 2023

El tratamiento penal de los menores que trasgreden la ley penal es un tema de recurrente preocupación, ante el aumento de la criminalidad. Se exige justicia sin importar si se vulneran derechos fundamentales de los menores de edad. Este artículo estudia el Sistema de Responsabilidad Penal Adolescente de Colombia, las sanciones que contempla, su enfoque de justicia restaurativa, aunque enmarcado dentro del derecho penal. Este sistema considera la sanción privativa de la libertad como último recurso de uso excepcional, pero este principio no se aplica plenamente. A la vez, hay presión por aumentar penas que puede vulnerar el interés superior del menor. Se concluye que es fundamental reforzar la aplicación de la justicia restaurativa para cumplir con los propósitos de prevención, reparación y reintegración social del menor.
Gobernanza policial en red para el control de hotspots de homicidios en Bogotá
Authors: Sandoval-Garrido Luis Eduardo , Velásquez-Monroy César Alfonso , Riaño-Bermudez Laura Carolina
Published: May 2023

El artículo explora el potencial de la gobernanza policial en red. Para hacerlo, usa el análisis de redes a fin de diseñar una red simulada de refuerzos entre patrullas de vigilancia comunitaria, por sectores urbanos o CAI, con base en los datos de la red observada que existía en 2016. La simulación se centra en los hotspots de homicidios de 2016 y se propone para evaluar si podría evitar su expansión o multiplicación en 2017. Se muestra que la red simulada controla y reduce potencialmente los hotspots, pese a los contextos urbanos y socioeconómicos que los sustentan y al recurso policial escaso.
MASTER (Motivating, Acquiring, Searching, Triggering, Exhibiting, Reflecting) learning model in terms of literacy ability and students' mathematics learning motivation
Authors: Sabirin Muhamad , Hidayatullah Akbar , Saputri Rinda Azmi , Atsnan Muh. Fajaruddin , Nareki Maisea Ledua
Published: May 2023

It is argued that mathematical literacy skills might be improved when learning motivation is high. This study aims to examine the difference in mathematical literacy skills between students who joined a learning model that stimulate motivation, the MASTER learning model (Motivating, Acquiring, Searching, Triggering, Exhibiting, and Reflecting) and those who attended conventional learning in terms of high, medium, and low learning motivation. This is a quasi-experimental study with a population of all seventh-grade students of an Islamic Junior School in South Kalimantan, Indonesia. The sample was selected using the purposive sampling technique with group VII A as the experimental class and group VII E as the control class. The instrument used was a test of students' mathematical literacy skills and a student's learning motivation questionnaire. The data were analyzed using a two-way ANOVA. The results showed that: (1) there were differences in mathematical literacy skills between students who attended the MASTER learning model and those who took conventional learning; (2) there were differences in mathematical literacy abilities between students with high, medium, and low motivation to learn, and (3) there was an interaction between the MASTER learning model and learning motivation on students' mathematical literacy abilities.