bluuebunny/crossref_metadata_2025 huggingface dataset:
Atherosclerotic plaque regression in homozygous familial hypercholesterolaemia: a case report of a long-term lipid-lowering therapy involving LDL-receptor-independent mechanisms
Authors: Khoury Etienne , Lauzière Alex , Raal Frederick J , Mancini John , Gaudet Daniel
Published: January 2023

Background

Homozygous familial hypercholesterolaemia (HoFH) is a rare and life-threatening genetic disease characterized by extremely elevated low-density lipoprotein cholesterol (LDL-C) levels, important xanthomatosis and increased risk of premature atherosclerotic cardiovascular disease. Management of HoFH at an early stage is recommended but conventional lipid-lowering therapies (LLTs) dependent on the LDL-receptor for clearance of LDL particles, are usually not sufficient. However, agents acting independently of the LDL-receptor, such as inhibitors of microsomal triglyceride transfer protein (MTP) or angiopoietin-like protein 3 (ANGPTL3), administered in combination, on top of standard-of-care LLT constitute a promising therapy for HoFH.

Case summary

The present case describes a long-term (>10 years) follow-up of a 52-year-old woman with severe HoFH, who was treated with conventional lipid-lowering medications (i.e. statins and ezetimibe) for several years before experiencing the risks and benefits that were encountered with the use of LDL-receptor-independent agents (MTP and ANGPTL3 inhibitors). This combination therapy demonstrated a good long-term safety and efficacy profile, while continuous monitoring of hepatic enzymes (sometimes requiring dose adjustments) and fat accumulation is recommended when using lomitapide.

Discussion

Treating this HoFH patient with an LLT involving the combination of MTP and ANGPTL3 LDL-receptor-independent inhibitors (lomitapide and evinacumab, respectively) showed remarkable improvement in LDL-C levels, disappearance of xanthomatosis and regression in atherosclerotic plaques. In addition to safety and efficacy, one should question the affordability and access hurdle that emerging combination of expensive therapies might constitute in the future for the payers. These challenges could eventually limit the clinical use of those innovative treatments despite their clinical benefit.
Modified approach for transcatheter correction of superior sinus venosus atrial septal defect: a case series
Authors: Schleiger Anastasia , Nordmeyer Johannes , Kramer Peter , Berger Felix
Published: January 2023

Background

Transcatheter correction of superior sinus venosus atrial septal defect (SVASD) with partial anomalous pulmonary venous drainage (PAPVD) of the right upper and/or right middle pulmonary vein (RUPV/RMPV) has recently been described as an alternative to surgical approach in a substantial number of patients. We describe a modified technical approach for transcatheter correction of SVASD using transoesophageal echocardiography (TOE) to confirm adequate stent landing zone and apposition and evaluate its feasibility, safety, and procedural success.

Case summary

From 2019 to 2021, three consecutive patients received a transcatheter correction of SVASD with PAPVD by redirecting the superior vena cava and RUPV/RMPV to the left atrium by implantation of a custom-made covered Cheatham platinum stent (10-zig, length: 60–80 mm). Prior to stent implantation, a balloon testing was performed in the anticipated landing zone using TOE to confirm complete defect closure and unobstructed pulmonary venous drainage. Stent deployment and flaring of the interior stent portion were performed with TOE guidance to confirm adequate landing zone and apposition and to avoid residual shunt or pulmonary vein obstruction.

Conclusion

Transcatheter correction of SVASD with PAPVD was performed without any complications. The follow-up period was 7.8, 13.6, and 29.8 months, respectively. During follow-up, no mortality, stent embolization, or obstruction of pulmonary venous drainage occurred. The TOE-guided modified transcatheter approach for correction of SVASD with PAPVD is safe and feasible with excellent post-procedural results and represents an alternative to surgical treatment in a pre-selected patient cohort.
Dynamics of Expenditures on Durable Goods: The Role of New-Product Quality
Authors: Bertolotti Fabio , Gavazza Alessandro , Lanteri Andrea
Published: January 2023

We study the role of new-product quality for the dynamics of durable-good expenditures around the Great Recession. We assemble a rich dataset on US new-car markets during 2004–12, combining data on transaction prices with detailed information about vehicles’ technical characteristics. During the recession, a reallocation of expenditures away from high-quality new models accounts for a significant decline in the dispersion of expenditures. In turn, car manufacturers introduced new models of lower quality. The drop in new-model quality persistently depressed the technology embodied in vehicles, and likely contributed to the slow recovery of expenditures.
Revealing the small proteome ofHaloferax volcaniiby combining ribosome profiling and small-protein optimized mass spectrometry
Authors: Hadjeras Lydia , Bartel Jürgen , Maier Lisa-Katharina , Maaß Sandra , Vogel Verena , Svensson Sarah L , Eggenhofer Florian , Gelhausen Rick , Müller Teresa , Alkhnbashi Omer S , Backofen Rolf , Becher Dörte , Sharma Cynthia M , Marchfelder Anita
Published: January 2023

In contrast to extensively studied prokaryotic ‘small’ transcriptomes (encompassing all small noncoding RNAs), small proteomes (here defined as including proteins ≤70 aa) are only now entering the limelight. The absence of a complete small protein catalogue in most prokaryotes precludes our understanding of how these molecules affect physiology. So far, archaeal genomes have not yet been analyzed broadly with a dedicated focus on small proteins. Here, we present a combinatorial approach, integrating experimental data from small protein-optimized mass spectrometry (MS) and ribosome profiling (Ribo-seq), to generate a high confidence inventory of small proteins in the model archaeon Haloferax volcanii. We demonstrate by MS and Ribo-seq that 67% of the 317 annotated small open reading frames (sORFs) are translated under standard growth conditions. Furthermore, annotation-independent analysis of Ribo-seq data showed ribosomal engagement for 47 novel sORFs in intergenic regions. A total of seven of these were also detected by proteomics, in addition to an eighth novel small protein solely identified by MS. We also provide independent experimental evidence in vivo for the translation of 12 sORFs (annotated and novel) using epitope tagging and western blotting, underlining the validity of our identification scheme. Several novel sORFs are conserved in Haloferax species and might have important functions. Based on our findings, we conclude that the small proteome of H. volcanii is larger than previously appreciated, and that combining MS with Ribo-seq is a powerful approach for the discovery of novel small protein coding genes in archaea.
Streptomycesdevelopment is involved in the efficient containment of viral infections
Authors: Luthe Tom , Kever Larissa , Hänsch Sebastian , Hardy Aël , Tschowri Natalia , Weidtkamp-Peters Stefanie , Frunzke Julia
Published: January 2023

The formation of plaques represents the hallmark of phage infection visualizing the clearance of the bacterial lawn in structured environments. In this study, we have addressed the impact of cellular development on phage infection in Streptomyces undergoing a complex developmental life cycle. Analysis of plaque dynamics revealed, after a period of plaque size enlargement, a significant regrowth of transiently phage-resistant Streptomyces mycelium into the lysis zone. Analysis of Streptomyces venezuelae mutant strains defective at different stages of cellular development indicated that this regrowth was dependent on the onset of the formation of aerial hyphae and spores at the infection interface. Mutants restricted to vegetative growth (ΔbldN) featured no significant constriction of plaque area. Fluorescence microscopy further confirmed the emergence of a distinct zone of cells/spores with reduced cell permeability towards propidium iodide staining at the plaque periphery. Mature mycelium was further shown to be significantly less susceptible to phage infection, which is less pronounced in strains defective in cellular development. Transcriptome analysis revealed the repression of cellular development at the early stages of phage infection probably facilitating efficient phage propagation. We further observed an induction of the chloramphenicol biosynthetic gene cluster highlighting phage infection as a trigger of cryptic metabolism in Streptomyces. Altogether, our study emphasizes cellular development and the emergence of transient phage resistance as an important layer of Streptomyces antiviral immunity.
Direct estimation ofVS30 using spatial autocorrelation and centreless circular array coefficient curves obtained from microtremor array data
Authors: Hayashida Takumi , Yokoi Toshiaki , Nepal Nityam , Olivar Mónica
Published: January 2023

The average S-wave velocity (VS) in the upper 30 m (VS30) is a proxy for seismic wave amplification. Microtremor array exploration is one of the available methods for site characterization, but the recorded data require complicated processing that can lead to different estimations of VS30 depending on the analyst and processing software. We propose a method of estimating VS30 by using derivatives obtained in the early stages of microtremor array data processing. Statistical analysis with 2376 virtually generated subsurface VS structure models revealed that the frequencies at which the spatial-autocorrelation (SPAC) coefficients and centreless circular array (CCA) coefficients take specific values strongly correlate with VS30, which we used to develop formulas for estimating VS30. Numerical validations using actual VS profiles at 616 sites in Japan showed that the proposed method could estimate VS30 with a root-mean-square deviation (RMSD) of 57–80 m/s with SPAC coefficients and 56m/s with CCA coefficients. Our proposed methods were applicable for 98–100 per cent of theVS profiles when we limited our estimation to sites with VS30 < 760 m/s. The results indicated that SPAC coefficients from arrays with radii of 8–20 m can be used for VS30 estimation and are less affected by incoherent noise. In contrast, CCA coefficients are much more sensitive to incoherent noise, which resulted in the overestimation of VS30. The estimated VS30 values from the recorded microtremor array data were in good agreement with the reference values from the actual VS profiles. The proposed method allows for robust and efficient VS30 estimation without relying on the analyst’s skills or software.
A mass conserving filter based on diffusion for gravity recovery and climate experiment (GRACE) spherical harmonics solutions
Authors: Goux O , Pfeffer J , Blazquez A , Weaver A T , Ablain M
Published: January 2023

Over the past two decades, the GRACE (Gravity Recovery and Climate Experiment) and GRACE Follow-On mission (GRACE-FO) have provided monthly measurements of the gravity field as sets of Stokes coefficients, referred to as spherical harmonics solutions. The variations of the gravity field can be used to infer mass variations on the surface of the Earth, mostly driven by the redistribution of water. However, unconstrained GRACE and GRACE-FO solutions are affected by strong correlated errors, easily identified as stripes along the north–south direction in the spatial domain. Here, we develop a filter based on the principle of diffusion to remove correlated errors and access the underlying geophysical signals. In contrast to many filters developed for this task, diffusion filters allow a spatially variable level of filtering that can be adapted to match spatially variable signal-to-noise ratios. Most importantly, the formalism of diffusion allows the implementation of boundary conditions, which can be used to prevent any flux through the coastlines during the filtering step. As mass conservation is enforced in the filter, global indicators such as trends in the global mean ocean mass are preserved. Compared with traditional filters, diffusion filters ensure the consistency of the solution at global and regional scales for ocean applications. Because leakage errors occurring during the filtering step are suppressed, better agreement is found when comparing diffusion-filtered spherical harmonic solutions with mascon solutions and independent estimates based on altimetry and in situ data.
Functional and Behavioral Trade-Offs between Terrestrial and Aquatic Locomotion in the Amphibious Fish Kryptolebias marmoratus
Authors: Axlid E G , Lewis P D , Carroll T J , Minicozzi M R
Published: January 2023

Synopsis

The mangrove rivulus (Kryptolebias marmoratus) is a phenotypically plastic teleost fish that can spend considerable time on land and traverse the terrestrial realm through a behavior termed the tail-flip jump. The tail-flip jump is a transitional stage between fully aquatic and terrestrial lifestyles. Therefore, understanding this behavior can provide insight into how organisms adapt to new environments over evolutionary time. Studies of K. marmoratus show that terrestrial acclimation and exercise improve tail-flip jumping performance due to muscle remodeling, but the implications of these muscular changes on aquatic locomotion are unknown. In the present study, we hypothesized that (1) terrestrial acclimation and exercise lead to physiological changes, such as changes to muscle fiber type, muscle mass distribution, or body shape, that optimize tail-flip jump distance and endurance while negatively impacting swimming performance in K. marmoratus, and (2) plasticity of the brain (which has been demonstrated in response to a variety of stimuli in K. marmoratus) allows terrestrial emersion and exercise to cause behavioral changes that promote survival and long-term reproductive success. To test these hypotheses, we measured the critical swimming speed (Ucrit), tail-flip jump distance, terrestrial endurance, and undisturbed aquatic behavior of age- and size-matched K. marmoratus before and after a terrestrial exercise period. This period consisted of six 3-min exercise sessions spread over 12 days, during which the fish were prompted to jump continuously. To isolate the effects of air exposure, a separate group was exposed to air for an equivalent period but not allowed to jump. Air exposure improved maximum jump distance but negatively affected swimming performance (Ucrit). Terrestrial endurance (number of jumps) improved in the exercised group, but Ucrit showed no significant change. Contrary to our first hypothesis, a trade-off exists between jump distance and Ucrit but not between jump endurance and Ucrit. Exercised individuals were more active following exercise, resulting either from the onset of dispersion behavior or a heightened stress response.
Impacts of the match-mismatch hypothesis across three trophic levels—a case study in the North Sea
Authors: Ferreira A Sofia A , Neuheimer Anna B , Durant Joël M
Published: January 2023

Sustainable fishery practices require accurate predictions of fish recruitment—the abundance of a new year class entering a fishery. A key driver of recruitment is the impact predator-prey dynamics experienced during early life stages has on their survival at later stages, as in the Match-Mismatch Hypothesis (MMH). MMH states that predator survival depends on the match (or mismatch) between the timing of predator feeding and that of prey availability. This study aims to understand how predator-prey spatio-temporal overlap explains the variation in a pelagic fish population. We explore the predator-prey overlap between each pair of three trophic levels in the North Sea (NS) from 1982–2017: herring (Clupea harengus) larvae, zooplankton (Temora longicornis, Oithona sp.,Pseudocalanus spp., and Acartia spp.), and a phytoplankton index. We found that MMH explained 23% of recruitment (1-year-old) of NS autumn-spawning (NSAS) herring, performed similarly (21–26%) when using different trophic levels, and that there was a spatial pattern in both the overlap and the negative relationship between the overlap and recruitment, similar to the variation of habitat use of NS herring. Our results characterize how the MMH, including spatial variability, plays in controlling herring recruitment, while also considering unexplained variation for future study.
From Fairies to Giants: Untangling the Effect of Body Size, Phylogeny, and Ecology on Vertebral Bone Microstructure of Xenarthran Mammals
Authors: Zack E H , Smith S M , Angielczyk K D
Published: January 2023

Synopsis

Trabecular bone is a spongy bone tissue that serves as a scaffolding-like support inside many skeletal elements. Previous research found allometric variation in some aspects of trabecular bone architecture (TBA) and bone microstructure, whereas others scale isometrically. However, most of these studies examined very wide size and phylogenetic ranges or focused exclusively on primates or lab mice. We examined the impact of body size on TBA across a smaller size range in the mammalian clade Xenarthra (sloths, armadillos, and anteaters). We µCT-scanned the last six presacral vertebrae of 23 xenarthran specimens (body mass 120 g–35 kg). We collected ten gross-morphology measurements and seven TBA metrics and analyzed them using phylogenetic and nonphylogenetic methods. Most metrics had similar allometries to previous work. However, because ecology and phylogeny align closely in Xenarthra, the phylogenetic methods likely removed some covariance due to ecology; clarifying the impact of ecology on TBA in xenarthrans requires further work. Regressions for Folivora had high P-values and low R-squared values, indicating that the extant sloth sample either is too limited to determine patterns or that the unique way sloths load their vertebral columns causes unusually high TBA variation. The southern three-banded armadillo sits far below the regression lines, which may be related to its ability to roll into a ball. Body size, phylogeny, and ecology impact xenarthran TBA, but parsing these effects is highly complex.
Compliance in Time: Lessons from the Inter-American Court of Human Rights
Authors: Pérez-Liñán Aníbal , Schenoni Luis , Morrison Kelly
Published: January 2023

This paper integrates the scholarship on compliance with international human rights courts to reflect upon how the literature approaches delays and compliance cycles. Building on this review, we propose a new analytical approach that helps distinguish between reparations prone to immediate or protracted implementation. We introduce two metrics to facilitate the interpretation of delays: the yearly probability of compliance and the expected time to compliance. We also show, using machine-learning tools, how scholars can reconstruct life cycles of compliance. The article illustrates the utility of this approach with an analysis of all cases decided by the Inter-American Court of Human Rights (IACtHR) between 1989 and 2019. This analytical framework provides critical insights for courts and activists seeking to promote interventions at key moments when compliance is most likely. Moreover, the study underscores important lessons for the Inter-American Human Rights System. Current concerns about a compliance “crisis” at the IACtHR partly reflect a failure to distinguish between reparation types and the Court's preference for reparations requiring protracted implementation. By modeling compliance life cycles, our study opens a promising research avenue that can facilitate effectual and timely policy intervention.
Regime Complexity as an Asset? The Negotiations of the Arms Trade Treaty
Authors: Panke Diana , Friedrichs Gordon M
Published: January 2023

The Arms Trade Treaty (ATT) is an important milestone in reducing the illicit trade of arms but was highly unlikely to be negotiated and passed. Major powers and states exporting and importing arms were not keen on universally binding regulations, leading to political stalemate in the initial negotiation arena, the Conference on Disarmament. This article investigates under which conditions regime complexity had a positive influence on the ATT negotiation dynamics and result. We distinguish between two types of regime complexity, each providing states with a distinct window of opportunity during international negotiations: horizontal regime complexity can allow states to overcome negotiation gridlock by changing the institutional conditions for passing an agreement. Vertical regime complexity can allow regional organizations to turn into agents of change by bringing in experiences gained on the regional level to the international negotiation table. Our empirical analysis of the ATT negotiations revealed critical scope conditions under which both forms of regime complexity function properly, allowing the negotiations to overcome negotiation gridlock and resulting in the passing of the accord beyond a lowest common denominator. The article contributes to the rich and vibrant scholarship in regime complexity and global governance complexes by making a novel analytical distinction between horizontal and vertical regime complexity and by identifying the opportunity structures under which regime complexity can have positive effects on the negotiation and outcome of international treaties.
Why Rules Matter: Shaping Security Council Sanctions Policy in Counterterrorism and Beyond
Authors: Dörfler Thomas
Published: January 2023

Sanctions are critical to the Security Council's efforts to fight terrorism. What is striking is that the Council's sanctions regimes are subject to detailed sets of rules and decision criteria. The scholarship on human rights in counterterrorism assumes that rights advocacy and court litigation have prompted this development. The article complements this literature by highlighting an unexplored internal driver of legal-regulatory decision-making and explores how mixed-motive interest constellations among Security Council members have affected the extent of committee regulations and the content of decisions taken by sanctions committees. Based on internal documents and diplomatic cables, a comparative analysis of the Iraq sanctions regime and the counterterrorism sanctions regime demonstrates that mixed-motive interest constellations among Security Council members provide incentives to elaborate rules to guide decision-making resulting in legal-regulatory sanctions governance, even if the human rights of targeted individuals are not at stake. For comparative leverage and to assess the limits of the proposed mechanism, the analysis is briefly extended to other sanctions regimes targeting individuals (Democratic Republic of the Congo and Sudan). The findings have implications for this essential tool of the Security Council to react to threats to peace as diverse as counterterrorism, nonproliferation, and internal armed conflict.
Cyberattacks, Psychological Distress, and Military Escalation: An Internal Meta-Analysis
Authors: Shandler Ryan , Gross Michael L , Canetti Daphna
Published: January 2023

To what extent can cyberattacks wreak havoc and terrorize modern society? Until now, this question has revolved around the potential of cyber operations to cause physical destruction or other material harm. In this paper, we propose a broader interpretation. We submit that assessing cyber-threats through the prism of physical destruction has obscured the human dimension of the threat. Instead, we propose calculating the gravity of cyberattacks by measuring psychological distress. This approach recognizes that even seemingly inconsequential cyberattacks can levy tremendous damage by traumatizing civilians, undermining societal cohesion, and exacerbating cycles of violence. To test whether cyberattacks cause significant individual harm, we employ an internal meta-analysis looking at eighteen studies conducted in three countries over 6 years. Across these studies, we exposed 6,020 respondents to simulated cyberattacks and conventional attacks. We conclude that cyberattacks can cause high levels of psychological harm—equal even to that caused by conventional political violence and terrorism. This finding overturns a widely accepted view that cyberattacks are a mere irritant at best and a threat to information security at worst. Through this lens, the findings suggest that even nonphysically destructive cyberattacks can trigger consequences that constitute a legally defined armed attack that permits using armed force in self-defense. We conclude by discussing how the onset of psychological distress generates political pressure in support of retaliation and can lead to military escalation.
Brideprice's Relationship to Conflict, Class, and Violence against Women
Authors: Johnston Melissa
Published: January 2023

Emerging research shows how brideprice facilitates conflict, as young men who cannot afford brideprice join armed groups. This article provides additional evidence for the role of brideprice in conflict, and shows how it facilitates three kinds of conflict: class conflict, interpersonal violence, and violence against women. In distinction to current approaches, this paper argues that brideprice's market logics are better conceived of as structured by gender and class inequality. Brideprice displays socioeconomic status and transfers wealth from poor to rich. Using ethnographic fieldwork undertaken in Timor-Leste, this article demonstrates that brideprice perpetuates socioeconomic inequality underpinning the Timorese class system. Recognizing the role of brideprice supports a clearer understanding of the continuum between conflict and violence.
Chikungunya: risks for travellers
Authors: Simon Fabrice , Caumes Eric , Jelinek Tomas , Lopez-Velez Rogelio , Steffen Robert , Chen Lin H
Published: January 2023

Rationale for review

Chikungunya outbreaks continue to occur, with changing epidemiology. Awareness about chikungunya is low both among the at-risk travellers and healthcare professionals, which can result in underdiagnosis and underreporting. This review aims to improve awareness among healthcare professionals regarding the risks of chikungunya for travellers.

Key findings

Chikungunya virus transmission to humans occurs mainly via daytime-active mosquitoes, Aedes aegypti and Aedes albopictus. The areas where these mosquitoes live is continuously expanding, partly due to climate changes. Chikungunya is characterized by an acute onset of fever with joint pain. These symptoms generally resolve within 1–3 weeks, but at least one-third of the patients suffer from debilitating rheumatologic symptoms for months to years. Large outbreaks in changing regions of the world since the turn of the 21st century (e.g. Caribbean, La Réunion; currently Brazil, India) have resulted in growing numbers of travellers importing chikungunya, mainly to Europe and North America. Viremic travellers with chikungunya infection have seeded chikungunya clusters (France, United States of America) and outbreaks (Italy in 2007 and 2017) in non-endemic countries where Ae. albopictus mosquitoes are present. Community preventive measures are important to prevent disease transmission by mosquitoes. Individual preventive options are limited to personal protection measures against mosquito bites, particularly the daytime-active mosquitos that transmit the chikungunya virus. Candidate vaccines are on the horizon and regulatory authorities will need to assess environmental and host risk factors for persistent sequelae, such as obesity, age (over 40 years) and history of arthritis or inflammatory rheumatologic disease to determine which populations should be targeted for these chikungunya vaccines.

Conclusions/recommendations

Travellers planning to visit destinations with active CHIKV circulation should be advised about the risk for chikungunya, prevention strategies, the disease manifestations, possible chronic rheumatologic sequelae and, if symptomatic, seek medical evaluation and report potential exposures.
GRB 160410A: The first chemical study of the interstellar medium of a short GRB
Authors: Agüí Fernández J F , Thöne C C , Kann D A , de Ugarte Postigo A , Selsing J , Schady P , Yates R M , Greiner J , Oates S R , Malesani D B , Xu D , Klotz A , Campana S , Rossi A , Perley D A , Blažek M , D’Avanzo P , Giunta A , Hartmann D , Heintz K E , Jakobsson P , Kirkpatrick IV C C , Kouveliotou C , Melandri A , Pugliese G , Salvaterra R , Starling R L C , Tanvir N R , Vergani S D , Wiersema K
Published: January 2023

Short gamma-ray bursts (SGRBs) are produced by the coalescence of compact binary systems which are remnants of massive stars. GRB 160410A is classified as a short-duration GRB with extended emission and is currently the farthest SGRB with a redshift determined from an afterglow spectrum and also one of the brightest SGRBs to date. The fast reaction to the Neil Gehrels Swift Observatory alert allowed us to obtain a spectrum of the afterglow using the X-shooter spectrograph at the Very Large Telescope (VLT). The spectrum shows several absorption features at a redshift of z = 1.7177, in addition, we detect two intervening systems at z = 1.581 and z = 1.444. The spectrum shows Ly α in absorption with a column density of log (N(H i)/cm2) = 21.2 ± 0.2 which, together with Fe ii, C ii, Si ii, Al ii, and O i, allow us to perform the first study of chemical abundances in a SGRB host galaxy. We determine a metallicity of [X/H]  = −2.3 ± 0.2 for Fe ii and −2.5 ± 0.2 for Si ii and no dust depletion. We also find no evidence for extinction in the afterglow spectral energy distribution modelling. The environment has a low degree of ionization and the C iv and Si iv lines are completely absent. We do not detect an underlying host galaxy down to deep limits. Additionally, we compare GRB 160410A to GRB 201221D, another high-z short GRB that shows absorption lines at z = 1.045 and an underlying massive host galaxy.
Interface instabilities in hydrodynamic relativistic jets
Authors: Abolmasov Pavel , Bromberg Omer
Published: January 2023

Both the dynamics and the observational properties of relativistic jets are determined by their interaction with the ambient medium. A crucial role is played by the contact discontinuity at the jet boundary, which in the presence of jet collimation may become subject to Rayleigh–Taylor instability (RTI) and Richtmyer–Meshkov instability (RMI). Here, we study the evolution of these instabilities in non-magnetized relativistic jets using special relativistic three-dimensional hydrodynamic simulations. We show that the growth of initial perturbations is consistent with relativistic RTI operating in the jet collimation region. The contribution of RMI becomes important downstream from the collimation shock in agreement with the theoretical expectations. Both instabilities reach non-linear scales above the shock convergence point and trigger strong turbulence, mixing the jet with the ambient matter. We devise an analytic solution for the mixing rate and show that it is sensitive to the external density gradients. Our results may be applied to different types of astrophysical objects. In particular, different contribution of interface instabilities is a natural explanation for the observed dichotomy between FR-I and FR-II radiogalaxies. The rapid slow-down in the jet of M87 is consistent with baryon entrainment from the circumnuclear matter with the observed density distribution. In microquasars, baryon loading triggered by interface instabilities is a probable reason for the low observed Lorentz factors. We show that the observed variability in gamma-ray bursts cannot come from mixing driven by interface instabilities and likely originates from the engine, suggesting the presence of magnetic fields in the jet.
OzDES Reverberation Mapping Program: Hβ lags from the 6-yr survey
Authors: Malik U , Sharp R , Penton A , Yu Z , Martini P , Lidman C , Tucker B E , Davis T M , Lewis G F , Aguena M , Allam S , Alves O , Andrade-Oliveira F , Asorey J , Bacon D , Bertin E , Bocquet S , Brooks D , Burke D L , Carnero Rosell A , Carollo D , Carrasco Kind M , Carretero J , Costanzi M , da Costa L N , Pereira M E S , De Vicente J , Desai S , Diehl H T , Doel P , Everett S , Ferrero I , Frieman J , García-Bellido J , Gerdes D W , Gruen D , Gruendl R A , Gschwend J , Hinton S R , Hollowood D L , Honscheid K , James D J , Kuehn K , Marshall J L , Mena-Fernández J , Menanteau F , Miquel R , Ogando R L C , Palmese A , Paz-Chinchón F , Pieres A , Plazas Malagón A A , Raveri M , Rodriguez-Monroy M , Romer A K , Sanchez E , Scarpine V , Sevilla-Noarbe I , Smith M , Soares-Santos M , Suchyta E , Swanson M E C , Tarle G , Taylor G , Tucker D L , Weaverdyck N , Wilkinson R D
Published: January 2023

Reverberation mapping measurements have been used to constrain the relationship between the size of the broad-line region and luminosity of active galactic nuclei (AGN). This R–L relation is used to estimate single-epoch virial black hole masses, and has been proposed to use to standardize AGN to determine cosmological distances. We present reverberation measurements made with Hβ from the 6-yr Australian Dark Energy Survey (OzDES) Reverberation Mapping Program. We successfully recover reverberation lags for eight AGN at 0.12 < z < 0.71, probing higher redshifts than the bulk of Hβ measurements made to date. Our fit to the R–L relation has a slope of α = 0.41 ± 0.03 and an intrinsic scatter of σ = 0.23 ± 0.02 dex. The results from our multi-object spectroscopic survey are consistent with previous measurements made by dedicated source-by-source campaigns, and with the observed dependence on accretion rate. Future surveys, including LSST, TiDES, and SDSS-V, which will be revisiting some of our observed fields, will be able to build on the results of our first-generation multi-object reverberation mapping survey.
Stellar feedback-regulated black hole growth: driving factors from nuclear to halo scales
Authors: Byrne Lindsey , Faucher-Giguère Claude-André , Stern Jonathan , Anglés-Alcázar Daniel , Wellons Sarah , Gurvich Alexander B , Hopkins Philip F
Published: January 2023

Several recent simulations of galaxy formation predict two main phases of supermassive black hole (BH) accretion: an early, highly intermittent phase (during which BHs are undermassive relative to local scaling relations), followed by a phase of accelerated growth. We investigate physical factors that drive the transition in BH accretion in cosmological zoom-in simulations from the FIRE project, ranging from dwarf galaxies to galaxies sufficiently massive to host luminous quasars. The simulations model multichannel stellar feedback, but neglect AGN feedback. We show that multiple physical properties, including halo mass, galaxy stellar mass, and depth of the central gravitational potential correlate with accelerated BH fuelling: constant thresholds in these properties are typically crossed within ∼0.1 Hubble time of accelerated BH fuelling. Black hole masses increase sharply when the stellar surface density in the inner 1 kpc crosses a threshold $\Sigma^\star _{1\,\rm kpc}\approx 10^{9.5} \, {\rm M_{\odot }}\,{\rm kpc}^{-2}$, a characteristic value above which gravity prevents stellar feedback from ejecting gas, and similar to the value above which galaxies are observed to quench. We further show that accelerated BH growth correlates with the emergence of long-lived thin gas discs, as well as with virialization of the inner circumgalactic medium. The halo mass Mhalo ∼ 1012 M⊙ and stellar mass M* ∼ 1010.5 M⊙ at which BH growth accelerates correspond to ∼L⋆ galaxies. The fact that stellar feedback becomes inefficient at ejecting gas from the nucleus above this mass scale may play an important role in explaining why AGN feedback appears to be most important in galaxies above L⋆.
The core normal Type Ia supernova 2019np – an overall spherical explosion with an aspherical surface layer and an aspherical 56Ni core
Authors: Hoeflich Peter , Yang Yi , Baade Dietrich , Cikota Aleksandar , Maund Justyn R , Mishra Divya , Patat Ferdinando , Patra Kishore C , Wang Lifan , Wheeler J Craig , Filippenko Alexei V , Gal-Yam Avishay , Schulze Steven
Published: January 2023

Optical spectropolarimetry of the normal thermonuclear supernova (SN) 2019np from −14.5 to +14.5 d relative to B-band maximum detected an intrinsic continuum polarization (pcont) of 0.21 ± 0.09 per cent at the first epoch. Between days −11.5 and  +0.5, pcont remained ∼0 and by day +14.5 was again significant at 0.19 ± 0.10 per cent. Not considering the first epoch, the dominant axis of ${\rm Si\, {\small II}}$ λ6355 was roughly constant staying close the continuum until both rotated in opposite directions on day  +14.5. Detailed radiation-hydrodynamical simulations produce a very steep density slope in the outermost ejecta so that the low first-epoch pcont ≈ 0.2 per cent nevertheless suggests a separate structure with an axis ratio ∼2 in the outer carbon-rich (3.5–4) × 10−3 M⊙. Large-amplitude fluctuations in the polarization profiles and a flocculent appearance of the polar diagram for the ${\rm Ca\, {\small II}}$ near-infrared triplet (NIR3) may be related by a common origin. The temporal evolution of the polarization spectra agrees with an off-centre delayed detonation. The late-time increase in polarization and the possible change in position angle are also consistent with an aspherical 56Ni core. The pcont and the absorptions due to ${\rm Si\, {\small II}}$ λ6355 and ${\rm Ca\, {\small II}}$ NIR3 form in the same region of the extended photosphere, with an interplay between line occultation and thermalization producing p. Small-scale polarization features may be due to small-scale structures, but many could be related to atomic patterns of the quasi-continuum; they hardly have an equivalent in the total-flux spectra. We compare SN 2019np to other SNe and develop future objectives and strategies for SN Ia spectropolarimetry.
Re-evaluating Homoploid Reticulate Evolution in Helianthus Sunflowers
Authors: Owens Gregory L , Huang Kaichi , Todesco Marco , Rieseberg Loren H
Published: January 2023

Sunflowers of the genus Helianthus are models for hybridization research and contain three of the best-studied examples of homoploid hybrid speciation. To understand a broader picture of hybridization within the annual sunflowers, we used whole-genome resequencing to conduct a phylogenomic analysis and test for gene flow between lineages. We find that all annual sunflower species tested have evidence of admixture, suggesting hybridization was common during the radiation of the genus. Support for the major species tree decreases with increasing recombination rate, consistent with hybridization and introgression contributing to discordant topologies. Admixture graphs found hybridization to be associated with the origins of the three putative hybrid species (Helianthus anomalus, Helianthus deserticola, and Helianthus paradoxus). However, the hybridization events are more ancient than suggested by previous work. Furthermore, H. anomalus and H. deserticola appear to have arisen from a single hybridization event involving an unexpected donor, rather than through multiple independent events as previously proposed. This means our results are consistent with, but not definitive proof of, two ancient independent homoploid hybrid speciation events in the genus. Using a broader data set that covers the whole Helianthus genus, including perennial species, we find that signals of introgression span the genus and beyond, suggesting highly divergent introgression and/or the sorting of ancient haplotypes. Thus, Helianthus can be viewed as a syngameon in which largely reproductively isolated species are linked together by occasional or frequent gene flow.
Periprosthetic humeral fracture revision using a massive allograft in a patient with rheumatoid arthritis: A case report
Authors: Kishimoto Kenji , Kojima Toshihisa , Takahashi Nobunori , Asai Shuji , Terabe Kenya , Suzuki Mochihito , Ohashi Yoshifumi , Kihira Daisuke , Maeda Masataka , Tatebe Masahiro , Imagama Shiro
Published: January 2023

Total elbow arthroplasty (TEA) is a surgical option for patients with rheumatoid arthritis (RA). Periprosthetic fractures during and after TEA are one of the most common causes of reoperation. Fractures around the stem of a loose prosthesis with associated bone loss are the most technically challenging to treat. Previous reports have demonstrated that the use of massive allografts is a reasonable alternative in salvage situations. Here, we report the case of a 78-year-old woman with RA who underwent revision TEA using massive allografts with modifications to the methods described in previous reports. She suffered a right periprosthetic humeral fracture 5 years after primary TEA, with a fracture in the proximal humeral diaphysis and a long spiral fracture in the diaphysis. The fracture around the stem of a loose prosthesis was associated with bone loss. We performed revision TEA using an allograft of the proximal femoral diaphysis. In contrast to previous reports, we preserved part of the humeral diaphysis, which was thin due to osteolysis, without removal. The advantage of this approach was that it preserved attachments, such as the deltoid and brachioradialis muscles. The patient had good elbow function and minimal pain without adverse events at 1 year postoperatively. Our findings suggest that preserving part of a thinned humeral diaphysis is a reasonable option in revision TEA with a massive composite allograft.
Association between animal protein sources and risk of neurodegenerative diseases: a systematic review and dose-response meta-analysis
Authors: Talebi Sepide , Asoudeh Farzaneh , Naeini Fatemeh , Sadeghi Erfan , Travica Nikolaj , Mohammadi Hamed
Published: January 2023

Context

Current findings about the differential effects of various sources of dietary animal protein on the risk of neurodegenerative diseases are contradictory.

Objective

The current meta-analysis was conducted to investigate the associations between intake of dietary animal protein sources and the risk of neurodegenerative diseases.

Data Sources

PubMed, Scopus, Web of Science, and Google Scholar databases were searched systematically until October 2021.

Data Extraction

Prospective cohort studies exploring the association between consumption of animal protein sources and risk of neurodegenerative diseases in the general population were included. Among 10 571 identified studies, 33 prospective cohort studies met the eligibility criteria.

Data Analysis

Dietary fish consumption was associated with a reduced risk of Alzheimer’s disease (RR = 0.75; 95%CI, 0.57–0.97), dementia (RR = 0.84; 95%CI, 0.75–0.93), and cognitive impairment (RR = 0.85; 95%CI, 0.81–0.95). The risk of developing Parkinson’s disease was significantly higher among those in the highest vs the lowest intake categories of total dairy (RR = 1.49; 95%CI, 1.06–2.10) and milk (RR = 1.40; 95%CI, 1.13–1.73). Moreover, dietary intake of total dairy (RR = 0.89; 95%CI, 0.80–0.99), total meat (RR = 0.72; 95%CI, 0.57–0.90), and poultry (RR = 0.82; 95%CI, 0.68–0.99) was significantly associated with a lower risk of cognitive impairment. A linear dose-response meta-analysis revealed that each 200-g increase in total daily dairy intake was associated with an 11% higher risk of Parkinson’s disease and a 12% lower risk of cognitive impairment. Furthermore, there was a strong linear association between fish consumption and reduced risk of dementia.

Conclusion

Dairy consumption is associated with an increased risk of Parkinson’s disease, but a higher intake of fish may be associated with lower risk of neurodegenerative disease. Future well-controlled, randomized clinical trials are essential to validate the present findings.

Systematic Review Registration

PROSPERO registration no. CRD42021281887.
Combining Sunitinib and Bevacizumab for the Management of Advanced Renal Cell Carcinoma: A Phase I/II Trial
Authors: Bazarbashi Shouki , Alzahrani Ahmed , Aljubran Ali , Elshenawy Mahmoud , Gad Ahmed Mostafa , Maraiki Fatima , Alzannan Noura , Elhassan Tusneem , Badran Ahmed
Published: January 2023

Background

Tyrosine kinase inhibitors remain a cornerstone in managing metastatic clear cell renal cell carcinoma (RCC). The 4 weeks on/2 weeks off intermittent sunitinib schedule could result in rebound angiogenesis and tumor progression in the 2-week rest period. We propose using bevacizumab during this period for continuous antiangiogenic effects.

Method

This was a phase I/II study of patients with advanced clear cell RCC. Sunitinib was given 50 mg daily on a 4-week on/2-week off schedule. Bevacizumab was given on day 29 of each sunitinib cycle. The bevacizumab starting dose was 5 mg/kg, and the dose was escalated to 10 mg if there was no dose-limiting toxicity. The primary endpoints were response rate and progression-free survival (PFS).

Results

Twenty-five patients were recruited. The study was closed prematurely because of poor accrual. No dose-limiting toxicity was observed with 5 mg bevacizumab. One patient achieved a complete response, and 12 achieved a partial response (52% response rate). At a median follow-up of 42.2 months (95%, confidence interval (CI) 32.9 to 51.4), the median PFS duration was 16.5 months (95% CI 4.1-28.8), and the median overall survival time was 33.3 months (95% CI 19.4-47.3). Twenty-two patients (88%) had at least one grade 3 or 4 toxicity; the most common were thrombocytopenia (32%), lymphopenia (32%), hypertension (28%), and fatigue (24%).

Conclusion

Continuous angiogenesis blockade by adding bevacizumab to the sunitinib on/off regimen for advanced RCC yields significant antitumor activity with manageable increased toxicity.
‘Managing Business with Respect’
Authors: Pachpande Sandeep , Pachpande Asha , Kulkarni J A
Published: January 2023

The ITC India company was incorporated in 1910. Much has changed in these 100 years. ITC itself has metamorphosed in many ways, the least of which is the multiple changes in nomenclature. What began and stayed for long as only a cigarette maker has turned into a conglomerate offering a dashboard of products and services, ranging from hospitality to toiletry to apparel to food. Of course, cigarettes remain a big but gradually shrinking part of its overall business.
Strategies for enriching and characterizing proteins with inhibitory properties on the yeast surface
Authors: Rezhdo Arlinda , Lessard Catherine T , Islam Mariha , Van Deventer James A
Published: January 2023

Display technologies are powerful tools for discovering binding proteins against a broad range of biological targets. However, it remains challenging to adapt display technologies for the discovery of proteins that inhibit the enzymatic activities of targets. Here, we investigate approaches for discovering and characterizing inhibitory antibodies in yeast display format using a well-defined series of constructs and the target matrix metalloproteinase-9. Three previously reported antibodies were used to create model libraries consisting of inhibitory, non-inhibitory, and non-binding constructs. Conditions that preferentially enrich for inhibitory clones were identified for both magnetic bead-based enrichments and fluorescence-activated cell sorting. Half maximal inhibitory concentration (IC50) was obtained through yeast titration assays. The IC50 of the inhibitory antibody obtained in yeast display format falls within the confidence interval of the IC50 value determined in soluble form. Overall, this study identifies strategies for the discovery and characterization of inhibitory clones directly in yeast display format.