bluuebunny/crossref_metadata_2025 huggingface dataset:
Community Drug Distributor Knowledge, Attitudes, and Motivation Surrounding Mass Drug Administration for Soil-Transmitted Helminths in India
Authors: Aruldas Kumudha , Kaliappan Saravanakumar Puthupalayam , Israel Gideon John , Palanisamy Gokila , Johnson Jabaselvi , Titus Angelin , Walson Judd L. , Means Arianna Rubin , Ajjampur Sitara Swarna Rao
Published: November 2021

Background: DeWorm3 is an ongoing multi-country community-based cluster-randomized trial assessing the feasibility of interrupting transmission of soil-transmitted helminths (STH) with community-wide mass drug administration (cMDA). In Tamil Nadu, India, community drug distributors (CDDs) worked with DeWorm3 field staff to counsel community members and deliver door-to-door deworming treatment. As CDDs were likely to influence successful delivery of cMDA, we describe drivers of CDDs' knowledge, attitudes, and motivation toward delivery of cMDA.

Methods: In this convergent mixed-methods study, a questionnaire on STH and cMDA was administered to 104 CDDs and 17 focus group discussions (FGDs) were conducted. Key outcomes in the quantitative and qualitative analyses included CDDs' knowledge about STH and cMDA and attitudes toward cMDA for STH. Univariate and multivariable logistic regression analyses were performed to determine the strength of associations between independent and outcome variables. The FGDs were analyzed using a priori thematic coding.

Results: CDDs who completed at least secondary school education [adjusted odds ratio (aOR): 2.71, 95% CI: 1.16–6.33] and had prior experience in health programs (aOR: 2.72, 95% CI: 1.15–6.44) were more knowledgeable about STH and cMDA. CDDs belonging to the scheduled castes and scheduled tribes (aOR: 2.37, 95% CI: 1.04–5.39), and to households engaged in a skilled occupation (aOR: 2.77, 95% CI: 1.21–6.34) had a more positive attitude toward cMDA for STH. The FGDs showed that while there were myths and misconceptions about STH, many CDDs believed that the adult population in their communities were infected with STH, and that a door-to-door drug delivery strategy would be optimal to reach adults.

Conclusions: Educational and socioeconomic backgrounds and experience in health programs should be considered while designing CDD trainings. Along with cMDA delivery for STH, as CDD do share community myths and misconceptions around STH, they should be proactively addressed during the CDD training to strengthen competency in counseling.
Parental Knowledge, Attitude, and Practice on Tobacco Use, Smoking Cessation, and Children's Environmental Tobacco Smoke Exposure
Authors: Dai Siyu , Au Chun Ting , Chan Michael Ho Ming , Kam Richard Kin Ting , Li Albert Martin , Chan Kate Ching-Ching
Published: November 2021

Background: Environmental tobacco smoke (ETS) exposure in children ranks one of the major public health problems in our time. Poor parental knowledge, attitude, and practice (KAP) on ETS often contribute to worse exposure of the kids. Thus, we aimed to document parental KAP regarding tobacco use, smoking cessation and children's ETS exposure, and to analyse how knowledge and attitude relate to practice.

Methods: Self-administered KAP questionnaires were distributed to smoking parents recruited from the pediatric unit at the Prince of Wales Hospital, which provides pediatric service to a population of 1.2 million in Hong Kong. The 60-item questionnaire had a range of 0–38 for knowledge, 0–44 for attitude, and 0–40 for practice. Descriptive analyses were performed for KAP response, regression analyses were performed for the exploration of associations and identification of predictive indicators.

Results: 145 smoking parents (mean age: 38.0 ± 6.7 yrs.; male: 85.5%) were included. Less than half (39.3%) of them reported a smoke-free policy at home. Among those parents who had private cars, less than half (45.2%) of them had smoke-free policy in their car that they never smoked in the car. Only 25.5% of the participants correctly answered ≥70% of the knowledge questions, and 11.8 % of the participants gave favorable responses to ≥70% of the attitude questions. The total knowledge and the total attitudes score were positively associated (r = 0.49, 95% CI: 0.35–0.79, p < 0.001), yet they were only modestly correlated with parental practice on children's ETS exposure. By multivariate regressions, potential predictive factors for more favorable parental KAP included higher household income, lower parental nicotine dependence level and breastfeeding practice.

Conclusions: Parental KAP related to tobacco use and children's ETS exposure needs improvement to address the significant gap between recommended and actual practice. The weak association between knowledge and practice suggested that parental education alone is not adequate to combat ETS exposure in children.
Aging Immune System and Its Correlation With Liability to Severe Lung Complications
Authors: Li Yongtao , Wang Chengfei , Peng Meilian
Published: November 2021

Aging is considered to be a decline in physical and physiological events that extensively affect the body's immunity, and is linked with deterioration in both innate and adaptive immune responses. The immune system exhibits profound age-associated variations, known as immunosenescence, comprising a significantly low production of B and T lymphocytes in bone marrow and thymus, a decreased function of mature lymphocytes in secondary lymphoid tissues, a decrease in the synthesis of fresh naïve T cells, and reduced activation of T cells. Elderly individuals face a greater risk for many diseases particularly respiratory diseases due to their poor response to immune challenges as vigorously as the young. The current review explored the aging immune system, highlight the mortality rates of severe lung complications, such as pneumonia, COVID-19, asthma, COPD, lung cancer, IPF, and acute lung injury, and their correlation with aging immunity. This study can be helpful in better understanding the pathophysiology of aging, immune responses, and developing new approaches to improve the average age of the elderly population.
How Did the COVID-19 Lockdown Affect Children and Adolescent's Well-Being: Spanish Parents, Children, and Adolescents Respond
Authors: Ajanovic Sara , Garrido-Aguirre Jon , Baro Bàrbara , Balanza Núria , Varo Rosauro , Millat-Martínez Pere , Arias Sara , Fonollosa Jordi , Perera-Lluna Alexandre , Jordan Iolanda , Muñoz-Almagro Carmen , Bonet-Carne Elisenda , Crosas-Soler Aina , Via Esther , Nafria Begonya , García-García Juan José , Bassat Quique
Published: November 2021

Background: During the COVID-19 pandemic, lockdown strategies have been widely used to contain SARS-CoV-2 virus spread. Children and adolescents are especially vulnerable to suffering psychological effects as result of such measures. In Spain, children were enforced to a strict home lockdown for 42 days during the first wave. Here, we studied the effects of lockdown in children and adolescents through an online questionnaire.

Methods: A cross-sectional study was conducted in Spain using an open online survey from July (after the lockdown resulting from the first pandemic wave) to November 2020 (second wave). We included families with children under 16 years-old living in Spain. Parents answered a survey regarding the lockdown effects on their children and were instructed to invite their children from 7 to 16 years-old (mandatory scholar age in Spain) to respond a specific set of questions. Answers were collected through an application programming interface system, and data analysis was performed using R.

Results: We included 1,957 families who completed the questionnaires, covering a total of 3,347 children. The specific children's questionnaire was completed by 167 kids (7–11 years-old), and 100 adolescents (12–16 years-old). Children, in general, showed high resilience and capability to adapt to new situations. Sleeping problems were reported in more than half of the children (54%) and adolescents (59%), and these were strongly associated with less time doing sports and spending more than 5 h per day using electronic devices. Parents perceived their children to gain weight (41%), be more irritable and anxious (63%) and sadder (46%). Parents and children differed significantly when evaluating children's sleeping disturbances.

Conclusions: Enforced lockdown measures and isolation can have a negative impact on children and adolescent's mental health and well-being. In future waves of the current pandemic, or in the light of potential epidemics of new emerging infections, lockdown measures targeting children, and adolescents should be reconsidered taking into account their infectiousness potential and their age-specific needs, especially to facilitate physical activity and to limit time spent on electronic devices.
Long-Term Trends in Unintentional Fall Mortality in China: A Population-Based Age-Period-Cohort Study
Authors: Wang Zhenkun , Hu Youzhen , Peng Fang
Published: November 2021

Background: Unintentional falls seriously threaten the life and health of people in China. This study aimed to assess the long-term trends of mortality from unintentional falls in China and to examine the age-, period-, and cohort-specific effects behind them.

Methods: This population-based multiyear cross-sectional study of Chinese people aged 0–84 years was a secondary analysis of the mortality data of fall injuries from 1990 to 2019, derived from the Global Burden of Disease Study 2019. Age-standardized mortality rates of unintentional falls by year, sex, and age group were used as the main outcomes and were analyzed within the age-period-cohort framework.

Results: Although the crude mortality rates of unintentional falls for men and women showed a significant upward trend, the age-standardized mortality rates for both sexes only increased slightly. The net drift of unintentional fall mortality was 0.13% (95% CI, −0.04 to 0.3%) per year for men and −0.71% (95% CI, −0.96 to −0.46%) per year for women. The local drift values for both sexes increased with age group. Significant age, cohort, and period effects were found behind the mortality trends of the unintentional falls for both sexes in China.

Conclusions: Unintentional falls are still a major public health problem that disproportionately threatens the lives of men and women in China. Efforts should be put in place urgently to prevent the growing number of fall-related mortality for men over 40 years old and women over 70 years old. Gains observed in the recent period, relative risks (RRs), and cohort RRs may be related to improved healthcare and better education.
The Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis
Authors: Li Zhenzhen , Tong Xiang , Liu Sitong , Yue Jirong , Fan Hong
Published: November 2021

Background: Timely and accurate diagnosis of tuberculosis (TB) remains a major challenge. Lipoarabinomannan (LAM) is a specific component of the cell envelope of Mycobacterium tuberculosis and is also a potential biomarker for the diagnosis of TB. Recently, the Fujifilm SILVAMP TB LAM test (FujiLAM), as a novel urine lateral flow LAM test, was developed for the diagnosis of TB and is convenient and timely. Because of a difference in the diagnostic value of FujiLAM in the original studies, we conducted a meta-analysis to comprehensively assess the diagnostic value of FujiLAM in TB.

Data Sources: We performed a literature search using the PubMed and EMBASE databases and commercial Internet search engines to identify studies.

Methods: Searches of databases using relevant terms (“tuberculosis” or “TB”) and (“Fujifilm SILVAMP TB LAM” or “FujiLAM”) were performed. Screening, study reviewing, data extracting and assessing data quality was performed independently by two reviewers. We calculated the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio. To minimize potential heterogeneity, we performed subgroup analyses.

Results: Nine articles were included in the meta-analysis. When using the microbiological reference standard (MRS), the results showed that the sensitivity and specificity of FujiLAM were 0.70 and 0.93, respectively, in adults with TB, while the sensitivity and specificity of FujiLAM in children with TB were 0.51 and 0.87. When using a comprehensive reference standard (CRS), the sensitivity and specificity of FujiLAM in adults with TB were 0.59 and 0.96, respectively, while the results showed that the sensitivity and specificity of FujiLAM in children with TB were 0.27 and 0.86, respectively. Subgroup analysis showed that FujiLAM had higher diagnostic sensitivity in patients with human immunodeficiency virus infection or CD4 cell counts < 200 cells/μL, both in adults and children.

Conclusions: This meta-analysis suggests that FujiLAM has a high value in the diagnosis of adults with TB.
Sex-Related Difference in the Association Between Child Neglect and the Accuracy of Body Weight Perception Among Chinese Primary Schoolchildren
Authors: Yu Hong-jie , Liu Xiangxiang , Liu Ming-wei , Zhang Min-zhe , Zheng Miaobing , He Qi-qiang
Published: November 2021

Introduction: Body weight perception (BWP) directly determines weight management behaviors. Although child neglect is a well-established risk factor for managing body weight, little is known about its association with the accuracy of BWP. This study aimed to assess the cross-sectional and longitudinal associations between child neglect and BWP accuracy in primary schoolchildren, and explore how these differ based on the sex of the child.

Methods: The sample included 1,063 primary schoolchildren (557 boys and 506 girls, aged 8–10 years) from a two-wave observational study between 2018 and 2019 in Wuhan, China. Child neglect and BWP were investigated using self-administered questionnaires. The accuracy of BWP was defined by comparing the BWP and actual body weight, and it was categorized into three groups—consistent, underestimated, and overestimated. Multinomial logistic regression analysis was conducted with fitting child neglect as the independent variable and the accuracy of BWP as the dependent variable.

Results: The prevalence of weight misperception was ~44% at baseline (underestimation 40%; overestimation 4%) in Chinese primary schoolchildren. In the cross-sectional analysis, children with a higher level of neglect were more likely to misperceive their body weight. Moreover, there was an apparent sex-related difference that boys who experienced a higher level of neglect significantly reported more underestimation, while girls reported more overestimation. There was no significant longitudinal association between child neglect and the change in BWP accuracy.

Conclusions: This study revealed that a higher level of neglect was significantly associated with underestimated BWP in boys and overestimated BWP in girls. The mechanisms of sex-related difference and whether child neglect is involved in the change in BWP, merit further investigations.
COVID-19 Vaccine Hesitancy in the United States: A Systematic Review
Authors: Yasmin Farah , Najeeb Hala , Moeed Abdul , Naeem Unaiza , Asghar Muhammad Sohaib , Chughtai Najeeb Ullah , Yousaf Zohaib , Seboka Binyam Tariku , Ullah Irfan , Lin Chung-Ying , Pakpour Amir H.
Published: November 2021

Vaccine hesitancy in the US throughout the pandemic has revealed inconsistent results. This systematic review has compared COVID-19 vaccine uptake across US and investigated predictors of vaccine hesitancy and acceptance across different groups. A search of PUBMED database was conducted till 17th July, 2021. Articles that met the inclusion criteria were screened and 65 studies were selected for a quantitative analysis. The overall vaccine acceptance rate ranged from 12 to 91.4%, the willingness of studies using the 10-point scale ranged from 3.58 to 5.12. Increased unwillingness toward COVID-19 vaccine and Black/African Americans were found to be correlated. Sex, race, age, education level, and income status were identified as determining factors of having a low or high COVID-19 vaccine uptake. A change in vaccine acceptance in the US population was observed in two studies, an increase of 10.8 and 7.4%, respectively, between 2020 and 2021. Our results confirm that hesitancy exists in the US population, highest in Black/African Americans, pregnant or breastfeeding women, and low in the male sex. It is imperative for regulatory bodies to acknowledge these statistics and consequently, exert efforts to mitigate the burden of unvaccinated individuals and revise vaccine delivery plans, according to different vulnerable subgroups, across the country.
Citizen Characteristics and Their Participation in Food Safety Social Co-governance: Public Health Implications
Authors: Chen Xiujuan , Qin Ke , Wu Linhai
Published: November 2021

Objective:Given that positive psychological capital motivates citizens to actively participate in social affairs, this study aims to provide insight into food safety risk management in China by empirically determining which individual characteristics are associated with positive psychological capital for actively participating in social co-governance.

Methods:A questionnaire-based survey was undertaken between December 5 and 10, 2020. The study participants were residents of Wuxi in China over the age of 18 years. A validated and pretested questionnaires was used to elicit responses with the participants. Student'st-test and one-way analysis of variance were performed to determine which individual characteristics are significantly correlated with the psychological capital of citizens who participate in co-governance.Post-hocmultiple comparisons were performed for each individual characteristic with a significant correlation to determine which categories of these characteristics yielded the significant differences. Study data were analyzed using IBM SPSS Statistics 24.0.

Results:A total of 752 completed responses were received. Most respondents were females (52.39%), aged 26–45 (66.09%), married (70.48%), company employees (44.28%), and in good health (89.76%). Most had a household size of 3 (55.98%), a bachelor's degree (40.96%), a personal annual income of more than 100,000 yuan (26.46%), and no children aged under 18 (50.27%) or pregnant women (93.22%) in their households. Data analysis indicated that education, income, and health status significantly associate with the psychological capital of citizens to participate in co-governance. Citizens with high education, high income, and good health status have higher psychological capital to participate in co-governance.

Conclusion:The present study suggested citizens are likely to actively participate in food safety social co-governance only when they have at least one of the following three characteristics: (1) higher than average income in their city of residence; (2) a bachelor's degree or higher education; or (3) good health. Therefore, motivating citizens to participate in co-governance is a long-term process in China. The fundamental strategy is to increase the income of citizens, especially among low-income groups, promote education to improve the food safety literacy of the public, and improve sanitation and public health.
Risk Perception Measurement and Influencing Factors of COVID-19 in Medical College Students
Authors: Qin Shangren , Zhou Mengqiu , Ding Ye
Published: November 2021

Purpose: In China, the coronavirus disease 2019 (COVID-19) pandemic has been under control and entered the normal prevention and control stage. For medical college students, many studies have analyzed their knowledge, risk perception, and prevention behaviors of COVID-19, but only a few pieces of research explore the content structure of COVID-19 risk perception and the influencing factors. This study measured the students' risk perception of COVID-19 and its dimensions and analyzed the influencing factors of risk perception among them.

Methods: The online questionnaire survey was conducted at Hangzhou Medical College in Zhejiang Province among undergraduates and junior college students. A scale was formulated to precisely measure and analyze the COVID-19 risk perception among medical college students. The factors affecting the COVID-19 risk perception in medical college students were analyzed using the multivariate linear regression model.

Results: A total of 810 medical students participated in the survey. Results show that COVID-19 risk perception among medical college students was divided into four dimensions: perceived health threat, perceived severity, perceived controllability, and perceived infection possibility. The results showed that income, education, major, and COVID-19 knowledge were the important factors affecting the COVID-19 risk perception of medical college students. Related factors have different influences on the various dimensions of COVID-19 risk perception. COVID-19 knowledge was significantly related to all dimensions of risk perception.

Conclusion: This study evaluates the content structure of medical college students' risk perception of COVID-19 precisely and related influencing factors. It is necessary to grasp the risk perception, prevention, and control behaviors of medical college students of different backgrounds, education levels, and majors. Further knowledge training should be conducted for students majoring in clinical medicine, especially the pandemic prevention and control measure training to enhance their sense of security at work.
Finite Element Analysis of Transhumeral and Transtibial Percutaneous Osseointegrated Endoprosthesis Implantation
Authors: Taylor Carolyn E. , Henninger Heath B. , Bachus Kent N.
Published: November 2021

Cadaveric mechanical testing of a percutaneous osseointegration docking system (PODS) for osseointegration (OI) prosthetic limb attachment revealed that translation of the exact system from the humerus to the tibia may not be suitable. The PODS, designed specifically for the humerus achieved 1.4–4.8 times greater mechanical stability in the humerus than in the tibia despite morphology that indicated translational feasibility. To better understand this discrepancy, finite element analyses (FEAs) modeled the implantation of the PODS into the bones. Models from cadaveric humeri (n = 3) and tibia (n = 3) were constructed from CT scans, and virtual implantation preparation of an array of endoprosthesis sizes that made contact with the endosteal surface but did not penetrate the outer cortex was performed. Final impaction of the endoprosthesis was simulated using a displacement ramp function to press the endoprosthesis model into the bone. Impaction force and maximum first principal (circumferential) stress were recorded to estimate stability and assess fracture risk of the system. We hypothesized that the humerus and tibia would have different optimal PODS sizing criteria that maximized impaction force and minimized first principal stress. The optimal sizing for the humerus corresponded to implantation instructions, whereas for the tibia optimal sizing was three times larger than the guidelines indicated. This FEA examination of impaction force and stress distribution lead us to believe that the same endoprosthesis strategy for the humerus is not suitable for the tibia because of thin medial and lateral cortices that compromise implantation.
Socioeconomic Challenges of California Strawberry Production and Disease Resistant Cultivars
Authors: Guthman Julie , Jiménez-Soto Estelí
Published: November 2021

Strawberries are the 4th highest grossing crop in California and supply 90% of US strawberries. But the industry's long reliance on the use of chemical fumigants to control soil disease, nematodes and weeds is being threatened by increased regulation of these fumigants, leading to urgent efforts to develop and test non-chemical alternatives to fumigation, such as disease resistant cultivars. Many of these technologies are promising ecologically, but making them economically viable for growers is more challenging, especially in light of the socioeconomic context of strawberry production in California that has created a state of lock-in for a sustainability transition. This paper discusses how the challenges of land prices, labor shortages, marketing standards, and low prices bear on cultivar selection. Based on qualitative interviews, we corroborate that strawberry growers operate under significant socioeconomic constraints in California, many of which are beyond their control. In addition, we find that most growers see high-yielding varieties as crucial to their economic viability with regard to land, labor, and marketing intermediaries and yet recognize that the focus on individual farm productivity works at cross purposes to the problem of poor prices. Disease resistant varieties do not at face value address the concerns voiced by most growers. Our findings suggest, however, that if some of the other pressures were exogenously mitigated, growers might be more inclined to experiment with and adopt disease resistant varieties, in combination with other approaches. The most promising policy avenues seem to therefore lie with support of grower revenues.
Automated Diagnostics: Advances in the Diagnosis of Intestinal Parasitic Infections in Humans and Animals
Authors: Inácio Sandra Valéria , Gomes Jancarlo Ferreira , Falcão Alexandre Xavier , Martins dos Santos Bianca , Soares Felipe Augusto , Nery Loiola Saulo Hudson , Rosa Stefani Laryssa , Nagase Suzuki Celso Tetsuo , Bresciani Katia Denise Saraiva
Published: November 2021

The increasingly close proximity between people and animals is of great concern for public health, given the risk of exposure to infectious diseases transmitted through animals, which are carriers of more than 60 zoonotic agents. These diseases, which are included in the list of Neglected Tropical Diseases, cause losses in countries with tropical and subtropical climates, and in regions with temperate climates. Indeed, they affect more than a billion people around the world, a large proportion of which are infected by one or more parasitic helminths, causing annual losses of billions of dollars. Several studies are being conducted in search for differentiated, more sensitive diagnostics with fewer errors. These studies, which involve the automated examination of intestinal parasites, still face challenges that must be overcome in order to ensure the proper identification of parasites. This includes a protocol that allows for elimination of most of the debris in samples, satisfactory staining of parasite structures, and a robust image database. Our objective here is therefore to offer a critical description of the techniques currently in use for the automated diagnosis of intestinal parasites in fecal samples, as well as advances in these techniques.
Endothelial Adenosine Monophosphate-Activated Protein Kinase-Alpha1 Deficiency Potentiates Hyperoxia-Induced Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension
Authors: Elsaie Ahmed , Menon Renuka T. , Shrestha Amrit K. , Gowda Sharada H. , Varghese Nidhy P. , Barrios Roberto J. , Blanco Cynthia L. , Konduri Girija G. , Shivanna Binoy
Published: November 2021

Bronchopulmonary dysplasia and pulmonary hypertension, or BPD-PH, are serious chronic lung disorders of prematurity, without curative therapies. Hyperoxia, a known causative factor of BPD-PH, activates adenosine monophosphate-activated protein kinase (AMPK) α1 in neonatal murine lungs; however, whether this phenomenon potentiates or mitigates lung injury is unclear. Thus, we hypothesized that (1) endothelial AMPKα1 is necessary to protect neonatal mice against hyperoxia-induced BPD-PH, and (2) AMPKα1 knockdown decreases angiogenesis in hyperoxia-exposed neonatal human pulmonary microvascular endothelial cells (HPMECs). We performed lung morphometric and echocardiographic studies on postnatal day (P) 28 on endothelial AMPKα1-sufficient and -deficient mice exposed to 21% O2 (normoxia) or 70% O2 (hyperoxia) from P1–P14. We also performed tubule formation assays on control- or AMPKα1-siRNA transfected HPMECs, exposed to 21% O2 or 70% O2 for 48 h. Hyperoxia-mediated alveolar and pulmonary vascular simplification, pulmonary vascular remodeling, and PH were significantly amplified in endothelial AMPKα1-deficient mice. AMPKα1 siRNA knocked down AMPKα1 expression in HPMECs, and decreased their ability to form tubules in normoxia and hyperoxia. Furthermore, AMPKα1 knockdown decreased proliferating cell nuclear antigen expression in hyperoxic conditions. Our results indicate that AMPKα1 is required to reduce hyperoxia-induced BPD-PH burden in neonatal mice, and promotes angiogenesis in HPMECs to limit lung injury.
Resveratrol Enhances the Cytotoxic Activity of Lymphocytes from Menopausal Women
Authors: Di Credico Andrea , Gaggi Giulia , Izzicupo Pascal , Bucci Ines , Di Baldassarre Angela
Published: November 2021

Nutraceuticals and functional foods are the main sources of antioxidants and have positive effects on health through regulation of the redox balance. Accordingly, they represent a useful nutritional source for the prevention of noncommunicable diseases (NCDs). Menopausal women have an increased risk of developing NCDs due to hormonal dysregulation and the ongoing aging process. Accordingly, a healthy lifestyle and good nutritional habits are of utmost importance in this population. Resveratrol (RSV) is a natural polyphenol, and it is used as a nutraceutical given its estrogenic, anti-inflammatory, and antioxidant properties. The aim of this study was to analyze the effects of RSV on the lymphocyte cytotoxicity in menopausal women. Lymphocytes from 13 healthy menopausal women (56.18 ± 4.24 years) were isolated, and then cocultured with hTERT-HME1, a breast cell line with a precancerous phenotype. The results showed that, when treated with RSV, lymphocytes significantly increased the TNF-α production (p < 0.001), the formation of immune synapses (p = 0.009), and the target cell lysis (p = 0.002). No effects were detected in the lymphocyte total antioxidant capacity. In conclusion, RSV might enhance the immune surveillance in menopausal women by increasing the cytotoxic activity of lymphocytes.
Chlorogenic Acid Attenuates Oxidative Stress-Induced Intestinal Epithelium Injury by Co-Regulating the PI3K/Akt and IκBα/NF-κB Signaling
Authors: Chen Jiali , Luo Yuheng , Li Yan , Chen Daiwen , Yu Bing , He Jun
Published: November 2021

Chlorogenic acid (CGA) is a natural polyphenol compound abundant in green plants with antioxidant and anti-inflammatory activities. Here, we explore its protective effects and potential mechanisms of action on intestinal epithelium exposure to oxidative stress (OS). We show that CGA attenuated OS-induced intestinal inflammation and injury in weaned pigs, which is associated with elevated antioxidant capacity and decreases in inflammatory cytokine secretion and cell apoptosis. In vitro study showed that CGA elevated phosphorylation of two critical signaling proteins of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway, Akt and nuclear factor erythroid-derived-related factor 2, leading to the elevated expression of intracellular antioxidant enzymes and heme oxygenase-1 (HO-1). Specific inhibition of HO-1 partially abolished its anti-inflammatory effect in IPEC-J2 cells exposure to OS. Interestingly, CGA suppressed the tumor necrosis factor-α (TNF-α) induced inflammatory responses in IPEC-J2 cells by decreasing phosphorylation of two critical inflammatory signaling proteins, NF-kappa-B inhibitor alpha (IκBα) and nuclear factor-κB (NF-κB). Specific inhibition of HO-1 cannot fully abolish its anti-inflammatory effect on the TNF-α-challenged cells. These results strongly suggested that CGA is a natural anti-inflammatory agent that can attenuate OS-induced inflammation and injury of intestinal epithelium via co-regulating the PI3K/Akt and IκBα/NF-κB signaling pathway.
Virtual Fire Evacuation Drills through a Web-Based Serious Game
Authors: Yang Yajun , Xu Zhen , Wu Yingying , Wei Wei , Song Ruizhuo
Published: November 2021

Evacuation capacity is very important in building fire. In order to improve the safety evacuation capacity of occupants, a web-based serious game for virtual fire evacuation drills is proposed. As a prototype of the serious game, a stand-alone system for virtual drill had been developed. On this basis, the system framework of the serious game is first designed for web-based training, including the database, front and back ends. Secondly, an optimization solution including fire scenes and web codes is designed for smooth rendering performance. Lastly, a solution is designed to visualize the evacuation paths of numerous trainees, which can be used to reveal the evacuation rules, and an evaluation model of evacuation performance is created considering the features of evacuation paths and fire hazards, to provide comprehensive feedback for trainees. Thus, a convenient and accessible web-based serious game was developed. More than 100 people participated in the online virtual evacuation drill of a dormitory building fire. Through the drills, the average evacuation time of the trainees decreases from 79.77 s to 54.32 s, and the safety scores of the trainees improve from 74.71 to 81.21. Therefore, the evacuation abilities of trainees gradually improve, which demonstrates the effectiveness of the drill. Consequently, virtual fire drills using a web-based serious game can play an important role in improving the evacuation ability.
Finite Element Modelling for Structural Performance of Slim Floors in Fire and Influence of Protection Materials
Authors: de Silva Donatella , Alam Naveed , Nadjai Ali , Nigro Emidio , Ali Faris
Published: November 2021

Slim floor systems are very common nowadays and various types are currently being used for the construction of high-rise buildings and car parks. Concrete in slim floor beams encases the steel beam section which helps to improve their fire resistance. Despite their higher fire resistance, several fire protection materials like intumescent coatings are often used to achieve a higher fire resistance where desired. The thermal properties and behaviour of various intumescent coating materials were previously studied through experimental investigations. This paper presents finite element analyses to simulate the response of unprotected and protected slim floor beams in fire using different simulation tools. For this purpose, fire tests conducted on unprotected slim floor beams and intumescent coating materials are modelled using research and commercial software. Results from the analyses are compared and verified with the available test data. These validated models are later combined to study the behaviour of protected slim floor beams in fire. Results from the study show that the research and the commercial software replicate the behaviour of slim floor beams and protection materials with good accuracy. Due to the presence of the intumescent coating, the protected slim floor beams displayed a better fire resistance as the temperature of the steel part remained below 400 °C even after 60-min of standard heating. The protected slim floor beams continued to support the external loads even after 120 min of heating.
Signature Modes of Old and New Violins with Symmetric Anatomical Wood Structure
Authors: Mihălcică Mircea , Stanciu Mariana Domnica , Nastac Silviu Marian , Dinulică Florin , Nauncef Alina Maria , Roșca Ioan Călin , Savin Adriana
Published: November 2021

The paper aims to investigate old and new violins from the perspective of the correlation between the anatomical structure of spruce and maple wood, and the dynamic response of violins. Thus, in the first stage, for each violin, the characteristics of the annual rings were measured on the entire width of the top plate, determining the degree of symmetry of the face with respect to the longitudinal axis of the violin body. Then, each violin was dynamically tested with the impact hammer, determining its own frequency spectrum, mainly the so-called “signature” mode and quality factors. The most important findings consist of identification of the first five modes for old violins, (known as provenance), current new violins, and violins whose origin is unknown, but which could correlate with anatomical, constructive and dynamic characteristics, in order to be able establish origins, and also the measurement of anatomical features of top and back plates in the violins’ construction.
Robust Lp-Norm Inversion for High-Resolution Fluid Contents from Nuclear Magnetic Resonance Measurements
Authors: Zhang Houzhu , Chen Jinhong
Published: November 2021

Fluid content computed from nuclear magnetic resonance (NMR) has proved to be an accurate and reliable tool for petrophysical property estimation. To overcome the limitations of conventional NMR measurements, high spatial resolution NMR (HSR-NMR) has been introduced to achieve the desired resolution for cores of any size. However, inversion of fluid contents from HSR-NMR data suffers from nonreliable measurements at the ends of the detection coil due to the heterogeneities of the magnetic fields caused by the relatively small size of the coil. A robust Lp-norm inversion algorithm, developed for geophysical inverse problems, has been implemented and applied on the inversion of NMR measurements. The estimated fluid content from Lp inversion matches well with the kerogen content in the cores both visually and quantitively. The resolution of the inverted fluid contents is as high as 1 inch. Further testing on the raw data with large derivations demonstrated that reliable results can only be achieved by using Lp inversion with low p’s values within the range of (1, 1.1).
Influence of the Lubrication Oil Temperature on the Disengaging Dynamic Characteristics of a Cu-Based Wet Multi-Disc Clutch
Authors: Zheng Liangjie , Ma Biao , Chen Man , Yu Liang , Wang Qian
Published: November 2021

Clutch disengaging dynamic characteristics, including the disengaging duration and the variations of friction pair gaps and friction torque, are crucial to the shifting control of an automatic transmission. In the present paper, the influence of lubrication oil (ATF) temperature on disengaging dynamic characteristics is investigated through a comprehensive numerical model for the clutch disengaging process, which considers the hydrodynamic lubrication, the asperity contact, the heat transfer, the spline resistance, and the impact between the piston and clutch hub. Moreover, the non-uniformity coefficient (NUC) is proposed to characterize the disengaging uniformity of friction pairs. As the ATF temperature increases from 60 °C to 140 °C, the clutch disengaging duration shortens remarkably (shortened by 55.1%); besides, the NUC sees a decreasing trend before a slight increase. When the ATF temperature is 80 °C, the distribution of friction pair gaps is most uniform. During the disengaging process, the increase of ATF temperature not only accelerates the change of the lubrication status between friction pairs but also contributes to the decrease of contact torque and hydrodynamic torque. This research demonstrates for the first time, evidence for clutch disengaging dynamic characteristics with the consideration of ATF temperature.
A Review of Activation Persulfate by Iron-Based Catalysts for Degrading Wastewater
Authors: Zhi Keke , Li Zhe , Ma Pengfei , Tan Yongxiang , Zhou Yuefeng , Zhang Weikang , Zhang Jingxing
Published: November 2021

Advanced oxidation technology of persulfate is a new method to degrade wastewater. As the economy progresses and technology develops, increasingly more pollutants produced by the paper industry, printing and dyeing, and the chemical industry are discharged into water, causing irreversible damage to water. Methods and research directions of activation persulfate for wastewater degradation by a variety of iron-based catalysts are reviewed. This review describes the merits and demerits of advanced oxidation techniques for activated persulfate by iron-based catalysts. In order to promote the development of related research work, the problems existing in the current application are analyzed.
Experimental Quantification of the Variability of Mechanical Properties in 3D Printed Continuous Fiber Composites
Authors: Becker Clarissa , Oberlercher Hannes , Heim Rosmarie Brigitte , Wuzella Günter , Faller Lisa-Marie , Riemelmoser Franz Oswald , Nicolay Pascal , Druesne Frédéric
Published: November 2021

The material properties of 3D printed continuous fiber composites have been studied many times in the last years. However, only a minimal number of samples were used to determine the properties in each of the reported studies. Moreover, reported results can hardly be compared due to different sample geometries. Consequently, the variability of the mechanical properties (from one sample to the other) is a crucial parameter that has not been well quantified yet. In the present work, the flexural properties of 3D printed continuous carbon fiber/nylon composite specimens were experimentally quantified, using batches of 15 test specimens. In order to account for the possible influence of the quality of the prepreg filaments on the observed variability, three different filament rolls were used to manufacture the different batches. Also, two configurations were tested, with a fiber direction parallel (longitudinal) or perpendicular (transverse) to the main axis of the specimens. The results show moderate to high variabilities of the flexural modulus, flexural strength and maximum strain. The coefficient of variation was more than twice as high in the transverse case as in the longitudinal case.
Fiducial Lower Confidence Limit of Reliability for a Power Distribution System
Authors: Cai Xia , Yan Liang , Li Yan , Wu Yutong
Published: November 2021

Reliability performance, especially the lower confidence limit of reliability, plays an important role in system risk and safety assessment. A good estimator of the lower confidence limit of system reliability can help engineers to make the right decisions. Based on the lifetime of the key component in a typical satellite intelligent power distribution system, the generalized fiducial method is adopted to estimate the lower confidence limit of the system reliability in this paper. First, the generalized pivotal quantity and the lower confidence limit of reliability for the key component are derived for the lifetimes of the exponential-type and Weibull-type components. Simulations show that the sample median is more appropriate than the sample mean when the lower confidence limit of reliability is estimated. Moreover, the lower confidence limit of reliability is obtained for the typical satellite intelligent power distribution system through the pseudo-lifetime data of the metallic oxide semiconductor field effect transistor. The lower confidence limit of reliability for this power distribution system at 15 years is 0.998, which meets the factory’s reliability requirement. Finally, through the comparison, a hot standby subsystem can be substituted with a cold standby subsystem to increase the lower confidence limit of the system reliability.
Development of a Hybrid Electric Vehicle Simulation Tool with a Rule-Based Topology
Authors: WON Hyun Woo
Published: November 2021

The performance of hybrid electric vehicles (HEVs) greatly depends on the various sub-system components and their architecture, and designers need comprehensive reviews of HEVs before vehicle investigation and manufacturing. Simulations facilitate development of virtual prototypes that make it possible to rapidly see the effects of design modifications, avoiding the need to manufacture multiple expensive physical prototypes. To achieve the required levels of emissions and hardware costs, designers must use control strategies and tools such as computational modeling and optimization. However, most hybrid simulation tools do not share their principles and control logic algorithms in the open literature. With this motivation, the author developed a hybrid simulation tool with a rule-based topology. The major advantage of this tool is enhanced flexibility to choose different control and energy management strategies, enabling the user to explore a wide range of hybrid topologies. The tool provides the user with the ability to modify any sub-system according to one’s own requirements. In addition, the author introduces a simple logic control for a rule-base strategy as an example to show the flexibility of the tool in allowing the adaptation of any logic algorithm by the user. The results match the experimental data quite well. Details regarding modeling principle and control logic are provided for the user’s benefit.
Influence of TTS Systems Performance on Reaction Times in People with Aphasia
Authors: Cistola Giorgia , Peiró-Lilja Alex , Cámbara Guillermo , van der Meulen Ineke , Farrús Mireia
Published: November 2021

Text-to-speech (TTS) systems provide fundamental reading support for people with aphasia and reading difficulties. However, artificial voices are more difficult to process than natural voices. The current study is an extended analysis of the results of a clinical experiment investigating which, among three artificial voices and a digitised human voice, is more suitable for people with aphasia and reading impairments. Such results show that the voice synthesised with Ogmios TTS, a concatenative speech synthesis system, caused significantly slower reaction times than the other three voices used in the experiment. The present study explores whether and what voice quality metrics are linked to delayed reaction times. For this purpose, the voices were analysed using an automatic assessment of intelligibility, naturalness, and jitter and shimmer voice quality parameters. This analysis revealed that Ogmios TTS, in general, performed worse than the other voices in all parameters. These observations could explain the significantly delayed reaction times in people with aphasia and reading impairments when listening to Ogmios TTS and could open up consideration about which TTS to choose for compensative devices for these patients based on the voice analysis of these parameters.
Exploration of the Potential Bioactive Molecules of Tamarillo (Cyphomandra betacea): Antioxidant Properties and Prebiotic Index
Authors: Reyes-García Verónica , Totosaus Alfonso , Pérez-Chabela Lourdes , Juárez Zaida Nelly , Cardoso-Ugarte Gabriel Abraham , Pérez-Armendáriz Beatriz
Published: November 2021

Tamarillo is an alternative for the consumption of food with high added value through various technological methodologies with nutritional quality and low cost, generating an economic impact on society. The objective of this research was to evaluate the potential of tamarillo red variety, as a source of bioactive compounds, to generate scientific information on the importance of its chemical composition and antioxidant and prebiotic properties. Different analyses were carried out: spectroscopic methods (IR, UV, NMR) of pulp flour and epicarp flour, antioxidant properties, prebiotic activity, and bromatological analysis. The spectra obtained by FTIR, UV, and NMR allowed the identification of chemical structures associated with the inulin-like functional groups. Pulp flour showed the highest prebiotic activity with values of 1.49 for Lactiacidbacillus. plantarum. Total phenolic compounds content in pulp flour was 206.23 mg/100 g dry weight, with an acceptable antioxidant property (ABTS+ = 6.27 TEAC and DPPH= %AA of 91.74 at a concentration of 250.00 µg/mL, 131.26 of IC50 ascorbic acid). The results regarding tamarillo as a source of bioactive molecules with important physiological properties as an antioxidant and putative prebiotic indicate it is a good alternative for the formulation of functional foods.