bluuebunny/crossref_metadata_2025 huggingface dataset:
Stem Cells Associated with Adult Skeletal Muscle Can Form Beating Cardiac Tissue In Vitro in Response to Media Containing Heparin, Dexamethasone, Growth Factors and Hydrogen Peroxide
Authors: Eisenberg Leonard M. , Eisenberg Carol A
Published: January 2025

Both cardiac and skeletal muscle originate from the mesoderm although the two tissues develop from distinct primordia within the early embryo. The shared, albeit distinctive muscle phenotype of these two cell types have led many researchers to investigate whether stem cells from adult skeletal muscle have the capacity to generate cells having a contractile, cardiac phenotype. To date, most of those studies have relied on multistep protocols requiring tissue engineering, co-cultures or transplantation experimentation. In this report, we describe a simple, cell culture method for obtaining contractile, cardiogenic aggregates from skeletal muscle-derived stem cells (MDSCs). Combining in vitro conditions used for promoting the differentiation of cardiac progenitor cells and the long-term maintenance of heart tissue fragments, we have been able to convert MDSCs to myocardial cells that aggregate into beating myospheres. These selective and optimized culture conditions continued to support a contractile cardiogenic phenotype for over four months in vitro. This culture protocol provides a model for future insights into the pathways responsible for divergence of skeletal and cardiac phenotypes, as well as a source of easily obtained myocardial tissue for subsequent scientific investigations into cardiac function and biology.
Development of Aqueous Polyethylene Oxide Gel Inks for the Pharmaceutical Semisolid-Extrusion 3D Printing of Plant-Origin Flavonoids
Authors: Koshovyi Oleh , Heinämäki Jyrki , Shpychak Alina , Meos Andres , Sandler Topelius Niklas , Raal Ain
Published: January 2025

Flavonoids are a vast class of phenolic substances. To date, there are approximately 6000 plant-origin flavonoids discovered, and many of them have found uses in drug therapy. Today, therapeutic flavonoids are commonly formulated to conventional “one size fits all” dosage forms, such as immediate-release tablets or hard capsules. The current trend in pharmacy and medicine, however, is personalized drug therapy and drug delivery systems (DDSs). Therefore, 3D printing is an interesting technique for designing and preparing novel personalized pharmaceuticals for flavonoids. The aim of the present study was to develop aqueous polyethylene oxide (PEO) gel inks loaded with plant-origin rutin (vitamin P) for semisolid-extrusion (SSE) 3D printing. Rutin (a model substance for therapeutic flavonoids), Tween 80, PEO (MW approx. 900,000), ethanol, and purified water were used in PEO gels at different proportions. The viscosity and homogeneity of the gels were determined. The rutin-PEO gels were printed with a bench-top Hyrel 3D printer to lattices and discs, and their weight and effective surface area were investigated. The key SSE 3D printing process parameters were established and verified. The results showed the compatibility of rutin as a model flavonoid and PEO as a carrier polymer. The rutin content (%) and content uniformity of the 3D-printed preparations were assayed by means of UV spectrophotometry and high-performance liquid chromatography (HPLC). The most feasible aqueous PEO gel ink formulation for SSE 3D printing contained rutin 100 mg/ml and Tween 80 50 mg/ml in a 12% aqueous PEO gel. The 3D-printed dosage forms are intended for the oral administration of flavonoids.
Usefulness of Detective Flow Imaging EUS in Intra-Abdominal Hypervascular Tumors
Authors: Nihei Shinichi , Kurita Yusuke , Sato Takamitsu , Honda Yu , Yamazaki Yuma , Iizuka Takeshi , Hasegawa Sho , Hosono Kunihiro , Utsunomiya Daisuke , Kobayashi Noritoshi , Kubota Kensuke , Ichikawa Yasushi , Endo Itaru , Nakajima Atsushi
Published: January 2025

: Background/Objectives: Although contrast-enhanced endoscopic ultrasound (CH-EUS) plays an important role in the ultrasound imaging-based diagnosis of intra-abdominal hypervascular tumors, detective flow imaging EUS (DFI-EUS), which can detect micro-blood flow without using a contrast agent, has recently emerged. In this study, we investigated the usefulness of DFI-EUS for detecting intra-abdominal hypervascular tumors. Methods: Thirteen patients with intra-abdominal hypervascular tumors detected on contrast-enhanced computed tomography who underwent DFI-EUS and CH-EUS were included. The lesions were classified into non-enhancement, hypo-enhancement, iso-enhancement, and hyper-enhancement patterns. Vascular structural patterns were classified as non-enhancement, homogeneous or heterogeneous enhancement. On DFI-EUS, patients who showed heterogeneous enhancement were evaluated for the presence or absence of dendritic and peritumoral capsule-like structures. Contrast patterns, vascular structure patterns, and detection capabilities of DFI-EUS and CH-EUS were examined. Results: The final diagnoses were pancreatic neuroendocrine neoplasm in 10 patients (76.9%), gastrointestinal neuroendocrine neoplasm in one patient (7.6%), gastrointestinal stromal tumor in one patient (7.6%), and metastatic pancreatic tumor in one patient (7.6%). The contrast patterns (DFI-EUS vs. CH-EUS) were non-enhancement in 7.7% vs. 0%, iso-enhancement in 15.3% vs. 23.0%, and hyper-enhancement in 76.9% vs. 76.9%. The vascular structure patterns (DFI-EUS vs. CH-EUS) showed a homogeneous enhancement of 0% vs. 100% and a heterogeneous enhancement of 92% vs. 0%. Patients with heterogeneous enhancement on DFI-EUS showed a dendritic structure in 91.6% and capsule-like structures in 75.0% of patients. Conclusions: DFI-EUS and CH-EUS showed comparable iso-enhancement or hyper-enhancement patterns. In contrast, DFI-EUS revealed the characteristic heterogeneous patterns of dendritic and capsular-like vascular structures.
UPAYA PENINGKATAN PENGETAHUAN ASUPAN NUTRISI IBU HAMIL DALAM MENCEGAH STUNTING DI PUSKESMAS TAMAMAUNG MAKASSAR
Authors: Jusuf Elizabet Catherine , Abidin Nuraini , Pakasi Suzanna , Bangsawan Nurbani , Syahrir Syahruni , Onterio Ahmed , Karim Radhiah
Published: January 2025

Abstrak: Stunting merupakan indikator dari kegagalan pertumbuhan anak. Prevalensi stunting di Sulawesi Selatan pada tahun 2022 mencapai 27,2%. Salah satu cara untuk mengatasi stunting adalah dengan meningkatkan asupan nutrisi dimulai pada 1000 hari pertama kehidupan anak. Dalam upaya mengurangi angka stunting, maka dilakukan kontribusi moril berupa penyuluhan kesehatan di Puskesmas, diharapkan mampu meningkatkan tingkat pengetahuan dan sikap masyarakat khususnya ibu hamil terhadap peningkatan status gizi dalam upaya mencegah stunting. Kegiatan ini dilakukan dengan cara penyuluhan kepada 50 orang di Puskesmas Tamamaung Makassar pada tanggal 4 Mei 2023. Dilakukan pengisian kuesioner awal sebelum penyuluhan dan pengisian kuesioner setelah penyuluhan. Data hasil kuesioner diolah dengan program SPSS. Hasil dari kegiatan ini yaitu kegiatan terlaksana dengan baik, peserta aktif dalam kegiatan sesi tanya jawab. Secara statistik didapatkan peningkatan nilai kuesioner sebelum dan sesudah penyuluhan dengan nilai p sebesar 0,000. Dari kegiatan ini dapat disimpulkan terjadi peningkatan pengetahuan masyarakat di wilayah Puskesmas Tamamaung tentang asupan nutrisi ibu hamil dalam mencegah stunting dimana terlihat berdasarkan hasil statistik pengisian kuesioner.
PENDAMPINGAN PETANI DALAM PENINGKATAN KUALITAS BUAH MELON DENGAN TRICHODERMA DAN BIOCHAR DI KWT ALAMANDA, KELURAHAN PACCERAKKANG
Authors: Mantja Katriani , Dermawan Rahmansyah , Yanti Cri Wahyuni Brahmi , Dariati Tigin , Ridwan Ifayanti , Sulaeha Sulaeha , Nurfaida Nurfaida , Iswoyo Hari , Faried Muhammad
Published: January 2025

Kelompok Wanita Tani (KWT) merupakan komponen pendukung ketahanan pangan di kota. Salah satunya yang berada di Kota Makassar, KWT Alamanda, belum memiliki pengetahuan dan keterampilan dalam memanfaatkan biochar pada budidaya tanaman di lahannya. Selain itu, pengetahuan terkait manfaat mikroba yang dapat membantu dalam meningkatkan ketahanan tanaman budidaya terhadap serangan penyakit terutama Trichoderma juga masih kurang dikalangan KWT mitra ini. Tujuan pengabdian pada masyarakat ini adalah sebagai transfer pengetahuan kepada mitra tentang penggunaan Biochar dan Trichoderma pada budidaya tanaman Melon. Metode yang digunakan pada kegiatan pengabdian ini adalah penyuluhan dan pelatihan dalam bentuk pendampingan budidaya Melon pada lahan KWT mitra. Selama kegiatan pengabdian, kelompok mitra secara aktif mengikuti penyuluhan dan pelatihan.  Sebanyak 20 orang anggota KWT Alamanda mengikuti kegiatan ini. Pendampingan dilakukan pada semua tahapan budidaya melon menggunakan biochar dan Trichoderma yang dilaksanakan pada  demonstration plot sejak persiapan lahan sampai panen. Dari kegiatan pengabdian dapat disimpulkan bahwa terjadi peningkatan pengetahuan dan keterampilan mitra sebesar 25% dalam melakukan budidaya tanaman melon yang diindikasikan oleh hasil pre-test dan post-test.
ABSTRACT
Women Farmers Group (KWT) is a supporting component of food security in the city. One of the KWTs in Makassar City, KWT Alamanda, does not have the knowledge and skills to utilize biochar in cultivating crops on their land. In addition, knowledge related to the benefits of microbes that can help increase the resistance of cultivated plants to disease attacks, especially Trichoderma, is still lacking among these KWT partners. The purpose of this community service is to transfer knowledge to partners about the use of Biochar and Trichoderma in Melon crop cultivation. The method used in this community service activity is counseling and training in the form of Melon cultivation assistance on the KWT partner's land. The partner group actively participated in counseling and training during the service activities.  A total of 20 members of KWT Alamanda participated in this activity. Assistance is carried out at all stages of melon cultivation using biochar and Trichoderma, which are carried out on demonstration plots from land preparation to harvest. From the service activities, it can be concluded that partners' knowledge and skills increased by 25% in cultivating melon plants, as indicated by the pre-test and post-test results.
Keywords: Melon, KWT, Biochar, Trichoderma.
OPTIMALISASI PEMANFAATAN PLATFORM CANVA UNTUK PENINGKATAN KUALITAS KONTEN EDUKASI PUBLIK DAN KEGIATAN KESEHARIAN DI DISKOMINFO TABANAN
Authors: Indrashwara Decky Cipta Indrashwara , Adisantosa I Kadek Purwita Adisantosa
Published: January 2025

Optimalisasi pemanfaatan platform Canva di Diskominfo Tabanan menjadi langkah strategis dalam meningkatkan kualitas konten edukasi publik dan kegiatan keseharian. Konten visual yang menarik ini membantu meningkatkan pemahaman dan kesadaran masyarakat terhadap isu-isu penting, serta mendorong partisipasi aktif mereka dalam berbagai kegiatan yang diselenggarakan oleh pemerintah daerah. Hal ini penting untuk membangun citra positif dan kepercayaan publik terhadap Diskominfo Tabanan sebagai lembaga yang kompeten dan inovatif dalam menyampaikan informasi. Metode pelaksanaan pada kegiatan ini adalah dengan melakukan edukasi dan pendampingan praktik secara langsung di lokasi kegiatan sebagai solusi dari permasalahan yang terjadi di lapangan. Permasalahan yang terjadi kemudian dianalisis setelah itu dicari solusi melalui teori-teori serta konsep-konsep keilmuan yang telah dipelajari. Hasil dari kegiatan ini, penggunaan platform Canva dapat signifikan meningkatkan kualitas dan efektivitas konten edukasi publik yang disampaikan oleh Diskominfo Tabanan kepada masyarakat. Diskominfo Tabanan menghadapi beberapa hambatan utama seperti kurangnya pengetahuan teknologi dan keterbatasan waktu untuk pembelajaran mendalam. Namun, dengan menerapkan strategi pendampingan yang melibatkan pelatihan intensif dan praktek langsung, Diskominfo Tabanan dapat mengatasi hambatan tersebut dengan efektif.
ABSTRACT
Optimizing the Canva platform at the Tabanan Diskominfo is a strategic step in improving the quality of public education content and daily activities. This attractive visual content helps increase public understanding and awareness of important issues, as well as encouraging their active participation in various activities organized by local governments. This is important to build a positive image and public trust in the Tabanan Diskominfo as an institution that is competent and innovative in conveying information. The implementation method for this activity is to provide education and direct practical assistance at the activity location as a solution to problems that occur in the field. The problems that arise are then analyzed and solutions are sought through the theories and scientific concepts that have been studied. The results of this research using the Canva platform can significantly improve the quality and effectiveness of public education content delivered by Diskominfo Tabanan to the public. Tabanan Diskominfo faces several main obstacles such as lack of technological knowledge and limited time for in-depth learning. However, by implementing a mentoring strategy that involves intensive training and direct practice, Diskominfo Tabanan can overcome these obstacles effectively.
Keywords: Canva, visual content, Diskominfo Tabanan.
PELATIHAN PRODUKSI KERIPIK SINGKONG DAN TEPUNG TAPIOKA KEPADA PEMUDA DESA WAIJARANG LEMBATA
Authors: Tukan Gerardus Diri , Bria Kristina , Wokal Monika Woli , Seran Sefriani Vidiani Luruk , Snoe Arkhangela Giriani , Matilda Oktaviana , Boikh Ananda Oky Mekel M. , Costa Silvestra Intan Nahak , Lasar Maria Wilhelmina , Tukan Gerardus Diri
Published: January 2025

Desa Waijarang, Kabupaten Lembata berdiri tahun 1995 dan menjadi lokasi relokasi bagi pengungsi. Masyarakat dominan sebagai petani dan menggarap lahan milik warga desa lain untuk berkebun. Desa Waijarang kini menjadi satu pintu masuk kabupaten Lembata dari jalur laut, karena terdapat pelabuhan kapal Fery, dan merupakan satu potensi bisnis. Namun, para pemuda desa kurang memiliki pengetahuan dan keterampilan untuk berwirausaha di bidang makanan dari hasil pertanian, seperti produk makanan camilan. Berdasarkan kondisi tersebut dilakukan pelatihan produksi keripik singkong dan tepung tapioka.  Metode kegiatan yaitu praktek produksi. Hasil kegiatan yang dilaksanakan selama dua minggu yakni diproduksi keripik singkong dari singkong parutan. Para pemuda terlibat aktif. Evaluasi kegiatan dilakukan setiap akhir pekan. Luaran yang dihasilkan yakni produk keripik berlogo Kingkong Waijar dan tepung tapioka. Peserta pelatihan serta pemerintah desa menyatakan gembira karena memperoleh pengetahuan dan inovasi baru tentang pengolahan singkong segar.  Disimpulkan bahwa kegiatan pelatihan berhasil dilakukan dan produk langsung dipasarkan.
ABSTRACT
Waijarang Village, Lembata Regency was established in 1995 and became a relocation location for refugees. The dominant community is farmers and works on land belonging to other villagers for gardening. Waijarang Village is now the entrance to Lembata Regency from the sea route, because there is a ferry port, and has business potential. However, village youth lack the knowledge and skills to become entrepreneurs in the field of food from agricultural products, such as snack food products. Based on these conditions, training was carried out on the production of cassava chips and tapioka flour.  The activity method is production practice. The results of the activities carried out for two weeks were the production of cassava chips from grated cassava. The youth are actively involved.  Evaluation of activities is carried out every weekend. The products produced are chips with the Kingkong Waijar logo and tapioka flour. The training participants and the village government expressed happiness because they had gained new knowledge and innovation about processing fresh cassava.  It was concluded that the training activities were successful and the product was immediately marketed.
Keywords: Kingkong waijar, Waijarang Village youth, production training.
PELATIHAN TEKNOLOGI BUDIDAYA LADA PERDU DI PEKARANGAN PADA KELOMPOK WANITA DI DESA PADANGLAMPE PANGKEP
Authors: Syam Netty , Nurliani Nurliani , Jabir Sitti Rahmah , Hidrawati Hidrawati
Published: January 2025

Pesantren Darul Mukhlisin milik Universitas Muslim Indonesia (UMI) yang ada di Desa Mitra Binaan Desa Padanglampe memiliki lahan yang sebahagian digunakan untuk tanaman lada sejak tahun 2015.  Populasi lada sekitar 800 pohon dan sudah  beberapa kali dipanen. Pengembangan lada oleh masyarakat di sekitar pesantren terkendala oleh adanya musim kering yang panjang di Desa Padanglampe yang berlangsung selama ≥ 6 bulan. Upaya pengembangan lada dilakukan dengan Program Pemberdayaan kelompok wanita  untuk membangun daya, mendorong motivasi, membangkitkan kesadaran akan potensi yang dimilikinya dan berusaha untuk mengembangkannya. Metode yang digunakan berupa metode pelatihan partisipatif, yaitu melibatkan sebanyak mungkin peran serta mitra dalam kegiatan ceramah, diskusi, dan praktek pendampingan teknologi dan cipta karya. Teknologi yang diberikan pada mitra berupa Pembibitan lada perdu dan metode penanaman bibit ke planterbag di pekarangan. Pelaksanaan kegiatan Pelatihan dan pendampingan sudah dilaksanakan melalui transfer teknologi pada Aspek produksi Mitra sangat antusias dan berpartisipasi sangat aktif dalam semua kegiatan pelatihan dan pendampingan.
ABSTRACT
Darul Mukhlisin Islamic Boarding School owned by the Indonesian Muslim University (UMI) located in the Partner Village of Padanglampe Village has land that has been partly used for pepper plants since 2015. The pepper population is around 800 trees and has been harvested several times. The development of pepper by the community around the Islamic boarding school is hampered by the long dry season in Padanglampe Village which lasts for ≥ 6 months. Efforts to develop pepper are carried out through the Women's Group Empowerment Program to build power, encourage motivation, raise awareness of their potential, and strive to produce it. The method used is a training method and community mentoring through active partner participation. The technology provided to partners is in the form of pepper shrub nurseries and a method of planting seeds in planter bags in the yard. Training and mentoring activities have been carried out through technology transfer in the production aspect. Partners are enthusiastic and participate actively in all training and mentoring activities.
Keywords: Shrubs pepper, group empowerment, Padanglampe Village.
BIOKONVERSI LIMBAH PABRIK TEH DALAM MENINGKATKAN PENDAPATAN USAHA PRODUKSI PUPUK ORGANIK PADA PT. MADINA ANEKA SUBUR
Authors: Haruna Harsani , Poleuleng Andi Besse , Hala Dian Magfirah , Nurnawati Andi Ayu , Indriani Susi , Rasbawati Rasbawati , Fajri Syarif Al , Mutmainna Mutmainna , Servianti Servianti , Yusbasari Yuki , Para’pean Yulius Tina’
Published: January 2025

Proses pembuatan pupuk organik oleh PT Madina Aneka Subur memanfaatkan limbah pabrik teh berupa ampas sebagai bahan baku pupuk organik. Limbah ampas teh merupakan bahan organik dan memiliki berbagai macam kandungan. Masih awamnya pemahaman mengenai Maggot yang meliputi manfaat dan cara budidaya Maggot sehingga jarang yang memanfaatkan Maggot sebagai pengurai bahan organik. Pelatihan dan pendampingan ini bertujuan untuk meningkatkan pemahaman PT Madina Aneka Subur dalam mengelola limbah pabrik teh dalam meningkatkan pendapatan usaha produksi pupuk. Metode pelaksanaan pelatihan dilakukan dengan cara ceramah serta diskusi, sedanngkan pendampingan dilakukan dengan cara praktek di lokasi PT Madina Aneka Subur. Hasil kegiatan menjunukkan semangat dan antusias dari PT Madina Aneka Subur yang ingin memahami lebih lanjut proses pengolahan dengan memanfaatkan Maggot. Hal ini ditunjukkan pada saat kegiatan lanjutan berupa pendampingan budidaya Maggot. Kegiatan pelatihan dan pendampingan biokonversi limbah pabrik teh dengan memanfaatkan maggot berlangsung lancar dan sukses serta pemahaman peserta dari  PT Madina Aneka Subur meningkat terkait pengolahan limbah pabrik teh dengan budidaya Maggot
Improved grey wolf optimizer for optimal reactive power dispatch with integration of wind and solar energy
Authors: Laouafi F.
Published: January 2025

The aim of this paper is to present a new improved grey wolf optimizer (IGWO) to solve the optimal reactive power dispatch (ORPD) problem with and without penetration of renewable energy resources (RERs). It is a nonlinear multivariable problem of optimization, with multiconstraints. The purpose is to minimize real power losses and improve the voltage profile of a given electric system by adjusting control variables, such as generator voltages, tap ratios of a transformer, switching VAr sources, without violating technical constraints that are presented as equalities and inequalities. Methodology. Metaheuristics are stochastic algorithms that can be applied to solve a wide variety of optimization problems without needing specific problem structure information. The penetration of RERs into electric power networks has been increased considerably to reduce the dependence of conventional energy resources, reducing the generation cost and greenhouse emissions. It is essential to include these sources in power flow studies. The wind and photovoltaic based systems are the most applied technologies in electrical systems compared to other technologies of RERs. Moreover, grey wolf optimizer (GWO) is a powerful metaheuristic algorithm that can be used to solve optimization problems. It is inspired from the social hierarchy and hunting behavior of grey wolves in the wild. The novelty. This paper presents an IGWO to solve the ORPD problem in presence of RERs. Methods. The IGWO based on enhancing the exploitation phase of the conventional GWO. The robustness of the method is tested on the IEEE 30 bus test system. For the control variables, a mixed representation (continuous/discrete), is proposed. The obtained results demonstrate the effectiveness of the introduced improvement and ability of the proposed algorithm for finding better solutions compared to other presented methods. References 40, tables 3, figures 9.
The impact of parasitic capacitances on the accuracy of scale transformation of high-voltage dividers
Authors: Haran Y. O. , Trotsenko Y. O. , Protsenko O. R. , Dixit M. M.
Published: January 2025

Purpose. The aim of this work is the determination of the parasitic capacitance’s influence on the accuracy of scale transformation of high-voltage dividers. Analyzing the possibilities of reducing such influence is a pressing problem for high voltage measurement, especially at high frequency range of input voltage. Methodology. Mathematical modeling of the voltage divider equivalent circuit, considering parasitic capacitances and inductances has been performed in the QUCS circuit simulator software under sinusoidal alternating current conditions in the range from 100 Hz to 1 MHz. Using the FEMM software, the finite element method was used to simulate the density distribution of capacitive currents in the module with capacitance graded insulation of the high-voltage arm of the voltage divider. Results. The results of the calculations show that the percentage of parasitic capacitive currents decreases exponentially depending on the ratio of the outer radii of the shielding disks to the distance between them. However, even with the outer radii of the shielding disks of about 3 m, capacitive currents still make up about 1 % of the total current flowing in the measuring circuit of the voltage divider. Instead of increasing outer radii, it is proposed to use high-voltage capacitance graded insulation between the shielding disks. As a result, a stable error of large-scale voltage transformation was obtained when the values of parasitic capacitances change, and it is proposed to manufacture the high-voltage arm of the voltage divider from the same type of high-voltage modules. Originality. The results of modeling the dependence of the accuracy of the voltage divider scale transformation on the ratio of the structural elements geometric parameters of its high-voltage arm were obtained. The solution has been proposed that involves changing the design of the high-voltage arm of the voltage divider, which significantly reduces the dependence of its scale transformation error on significant changes in the parasitic capacitances of the structure components on grounded surfaces. Practical value. The results of mathematical modeling of the characteristics of the voltage divider high-voltage arm make it possible to design, for the purpose of serial production, the same type of high-voltage modules for assembling on-site broadband voltage dividers for any nominal voltage, which will have the possibility of integration into Smart Grid systems. References 23, tables 1, figures 8.
Successful Healing After Minimally Invasive Subtalar Fusion Following Comminuted Open Calcaneus Fracture
Authors: Ranganathan Noopur , Aslan Lercan , Raza Marium , Miller Christopher P.
Published: January 2025

Case:

A 51-year-old male polytrauma patient presented with bilateral calcaneus fractures after a fall. This report describes treatment of his right comminuted Sanders IV calcaneus fracture with percutaneous open reduction internal fixation (ORIF) and minimally invasive surgery (MIS) primary subtalar fusion to restore alignment and preserve soft tissue.

Conclusion:

Unlike traditional open approaches, which are prone to wound complications due to larger incisions, our approach of maintaining fracture alignment during joint preparation using an MIS burr for acute posttrauma subtalar arthrodesis and percutaneous ORIF appears to have reduced these risks, resulting in successful radiological healing and functional recovery at 1-year follow-up.
High-resolution, Wide-frequency-range Magnetic Spectroscopy with Solid-state Spin Ensembles
Authors: Walsworth Ronald , Yin Zechuan , Welter Justin , Hart Connor , Petruzzi Paul
Published: January 2025

Quantum systems composed of solid-state electronic spins can be sensitive detectors of narrowband magnetic fields. A prominent example is the nitrogen-vacancy (NV) center in diamond, which has been employed for magnetic spectroscopy with high spatial and spectral resolution. However, NV-diamond spectroscopy protocols are typically based on dynamical decoupling sequences, which are limited to low-frequency signals (≲ 20 MHz) due to the technical requirements on microwave (MW) pulses used to manipulate NV electronic spins. In this work, we experimentally demonstrate a high-resolution magnetic spectroscopy protocol that integrates a quantum frequency mixing (QFM) effect in a dense NV ensemble with coherently averaged synchronized readout (CASR) to provide both a wide range of signal frequency detection and sub-Hz spectral resolution. We assess the sensitivity of this QFM-CASR protocol across a frequency range of 10 MHz to 4 GHz. By measuring the spectra of multi-frequency signals near 0.6, 2.4 and 4 GHz, we demonstrate sub-Hz spectral resolution with a nT-scale noise floor for the target signal, and precise phase measurement with error <1°. Compared to state-of-the-art NV-diamond techniques for narrowband magnetic spectroscopy, the QFM-CASR protocol greatly extends the detectable frequency range, enabling applications in high-frequency radio frequency (RF) and MW signal microscopy and analysis, as well as tesla-scale nuclear magnetic resonance (NMR) spectroscopy of small samples.
Raspberry-derived carbon dots for specific detection of intracellular copper ions
Authors: Xu Yalan , Liu Yiwei , Feng Liping , Wang Muhua , Xia Yueyi , Yang Luoxing , Yuwang Junjie , Sun Xiaoli
Published: January 2025

The detection of intracellular copper ions is of significant importance in biomedical research and disease diagnosis. In this study, blue emissive carbon dots (B-CDs) were successfully synthesized using raspberries as a carbon source through a simple hydrothermal method. Transmission electron microscopy (TEM) analysis revealed that the B-CDs had an average particle size of 9.05 nm. Characterization techniques combined with theoretical calculations, confirmed that the fundamental structural unit of B-CDs is a twelve-membered aromatic ring rich in oxygen and nitrogen functional groups. The B-CDs exhibited high selectivity for Cu²⁺ ions, showing a strong linear response in the concentration range of 0 to 150 µM, with a detection limit of 0.39 µM. Zeta potential and hydrodynamic size measurements indicated that the B-CDs interact with Cu²⁺ ions via electrostatic forces. Further studies revealed that the fluorescence quenching of B-CDs in the presence of Cu²⁺ is primarily due to a dynamic quenching process. Moreover, B-CDs were successfully applied to detect intracellular Cu²⁺. These findings not only show significant potential of B-CDs in fluorescence sensing but also provide valuable insights for the design of efficient carbon-based sensors.
Harmonic Oscillator with Variable Damping Coefficient
Authors: N Vinoj M , S Rajesh , G Seema V
Published: January 2025

Damped harmonic oscillator with damping coefficient as a linear function of position coordinate is represented by nonlinear ordinary differential equation. Solution of this equation is studied using both two-timing perturbation method and numerical method. Both solutions match exactly eventhough the perturbation term is not infinitesimally small in the underdamped case. The rate of variation of energy is found to be very slowly when damping coefficient varies as a linear function position coordinate as compared with constant damping case. There exist only one critical point, the origin, which is asymptotically stable in the underdamped situation. In the critically damped and overdamped conditions the critical point behaves like stable node.
Metacognition’s Moderation Effect between Engagement with Large Language Model and Reflection of Its Usage in EFL Writing among Chinese University Students
Authors: Song Jun
Published: January 2025

As a contributor to success in EFL (English as a foreign language) learning, the function of metacognition in digital intelligence era needs exploration. The study aimed to explore whether metacognition was functional when manipulating Large Language Models (LLM) to EFL writing. The present study adopted the moderation modeling approach to examine the interactive effect of metacognition implied between Chinese university students’ engagement with LLM and their reflection of LLM usage in EFL writing. 212 Students who graduated from Chinese tertiary institutions and studied at Chinese tertiary institutions currently are recruited as participants. They were required to complete a modified questionnaire containing 20 5-point Likert items to investigate whether their engagement with LLM could positively affect their reflection of LLM usage in EFL writing, and whether or not an effect is significant in predicting reflection of LLM usage when looking at the interaction effect between engagement with LLM and metacognition. The potential influence between engagement with LLM and reflection of LLM usage in EFL writing was statistically significant via simple linear regression. Moderation analysis retrieved from Sato’s (2023) research examined metacognition as an interaction term between engagement with LLM and reflection of LLM usage, however, the role of metacogntion was also not effective. Findings suggest that LLM is effective for EFL writing class, while what kind of factor on reflection of LLM usage will be influenced by metacognition still needs further exploration.
Single-Position Robot-Assisted Laparoscopic Nephroureterectomy for Duplicated Kidneys and Ureters: Technique and Outcomes
Authors: Sun Wei-Cheng , Zhang Feng , Sun Jia-Ning , Wang Xiao-Yan , Tang Gong-Lin , Chen Xin , Liu Chen-Yue , Zhao Jun-Dong , Zhao Hong-Wei
Published: January 2025

Purpose
Robot-assisted laparoscopic nephroureterectomy has reached a high level of maturity. However, operating on patients with duplex kidneys presents added challenges, primarily due to the large-scale resection and the need for re-positioning. This study aims to elaborate on the technique and outcomes of single-position robot-assisted nephroureterectomy for duplicated kidneys and ureters.
Methods
In our department, 23 patients diagnosed with duplicated renal collecting systems were selected. 10 patients underwent single-position robot-assisted laparoscopic nephroureterectomy (single-position group), and 13 had traditional robot-assisted laparoscopic nephroureterectomy (non-single-position group). We systematically collected their demographic data, surgical indications, and perioperative variables, and meticulously evaluated the surgical outcomes.
Results
All 23 patients underwent successful surgeries without conversion to open procedures. No remarkable differences were detected in the baseline clinical characteristics. The single-position group had a shorter operation time (166.20 ± 21.29 min vs. 208.31 ± 23.30 min, p < 0.001) and drainage tube indwelling time (3.50 ± 0.53 days vs. 4.15 ± 0.69 days, p < 0.05). Additionally, a statistically significant disparity in estimated blood loss (EBL) was noted between the two groups (136.00 ± 18.14 ml vs. 165.77 ± 40.72 ml, p < 0.05). There were no differences in post-operative hospital stays and pre-and post-operative estimated glomerular filtration rate (eGFR), and no recurrence was observed.
Conclusion
Single-position robot-assisted nephroureterectomy is both a reliable and secure surgical treatment for duplicated renal collecting systems, offering benefits such as reduced operative time, minimal minor complications, less estimated blood loss, and a high rate of surgical success.
Unraveling the association between retinal thickness and Alzheimer's disease, and circulating total-tau levels: Insights from genetic evidence
Authors: Sheng Dandan , Wang Song , Xiao Zheng , Liu Weiping , Xiao Bo , Zhou Luo
Published: January 2025

Background
Observational studies have reported associations between retinal thickness and Alzheimer’s disease (AD); however, the causal relationship remains uncertain.
Methods
We investigated the potential causal relationship between retinal thickness and AD using Mendelian randomization (MR) and genetic colocalization analyses. Multiple genome-wide association studies (GWAS) of European ancestry were used for MR causal inference. Summary-level data on retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness were sourced from the UK Biobank (N = 31,434). AD data were obtained from a GWAS meta-analysis conducted by the International Genomics of Alzheimer’s Project for discovery (N = 63,926) and an independent European GWAS cohort for replication (N = 85,934). Circulating total-tau biomarker data were derived from another GWAS in individuals of European ancestry (N = 14,721). The inverse-variance weighted (IVW) method served as the primary analytical approach, supplemented by MR-Egger, robust adjusted profile score, maximum likelihood, and weighted median methods. Sensitivity analyses included Cochran’s Q test, MR-Egger intercept test, leave-one-out analysis, and MR pleiotropy residual sum and outlier analysis to ensure robustness. Genetic colocalization analysis was performed to identify potential shared causal variants between retinal thickness and AD.
Results
The IVW estimates from the discovery MR analysis indicated no statistically significant causal effect of genetically predicted RNFL or GC-IPL thickness on AD or circulating total-tau levels, and reverse MR analysis found no causal link either (PIVW > 0.05). Replication bidirectional MR analysis produced consistent negative results (PIVW > 0.05). Sensitivity analyses demonstrated robustness across all MR methods, with no evidence of heterogeneity, horizontal pleiotropy, or instrumental variable outliers. Genetic colocalization analysis identified no shared causal variants between RNFL or GC-IPL thickness and AD or circulating total-tau (posterior probability H4 < 0.75).
Conclusion
Our study does not support a genetic causal link between retinal thickness, AD, and circulating total-tau levels, despite previous observational studies suggesting an association between retinal thinning and higher AD risk. Further research is needed to clarify the relationship between RNFL and GC-IPL thickness and AD, as well as the underlying biological mechanisms.
An Algorithm for Shape-Based Distance of Microseismic Time Series Waveforms and its Application in Clustering Mining Events
Authors: Luo Hao , Liu Ziyu , Ge Song , Ding Linlin , Zhang Li
Published: January 2025

To improve the efficiency and accuracy of microseismic event extraction from time-series data and enhance the detection of anomalous events, this paper proposes a Multi-scale Fusion Convolution and Dilated Convolutions Autoencoder (MDCAE) combined with a Constraints Shape-Based Distance algorithm incorporating volatility (CSBD-Vol). MDCAE extracts low-dimensional features from waveform signals through multi-scale fusion and dilated convolutions while introducing the concept of waveform volatility (Vol) to capture variations in microseismic waveforms. An improved Shape-Based Distance (SBD) algorithm is then employed to measure the similarity of these features. Experimental results on a microseismic dataset from the 802 working face of a mining site demonstrate that the CSBD-Vol algorithm significantly outperforms SBD, Shape-Based Distance with volatility (SBD-Vol), and Constraints Shape-Based Distance (CSBD) in classification accuracy, verifying the effectiveness of constrained time windows and volatility in enhancing performance. The proposed clustering algorithm reduces time complexity from \((O(n^2))\) to \((O(n \log n))\), achieving substantial improvements in computational efficiency. Furthermore, the MDCAE-CSBD-Vol approach achieves 87% accuracy in microseismic time-series waveform classification. These findings highlight that MDCAE-CSBD-Vol offers a novel, precise, and efficient solution for detecting anomalous events in microseismic systems, providing valuable support for accurate and high-efficiency monitoring in mining and related applications.
Effect of temporomandibular joint anterior disc displacement on condylar height in different age groups
Authors: Wu Siyu , Zhang Dahe , Xia Simo , Shen Pei , Yang Chi
Published: January 2025

Background:Temporomandibular joint ADD is highly prevalent and harmful, and some patients have no obvious clinical symptoms, but it can cause facial asymmetry, mandibular retrusion and other dental and maxillofacial deformities. Nevertheless, the impact of ADD on condylar height in individuals of varying age groups remains uncertain particularly with regard to condylar heights at different stages of development. The aim of this retrospective self-controlled study was to investigate the association between condylar height and temporomandibular joint anterior disc displacement (ADD) in different age groups.
Materials and Methods: Patient characteristics, condylar height, disc length, and displacement distance at the baseline (T0) and the second follow-up visit (T1) were collected, and the differences between the two-time points were analyzed.
Results: A total of 149 patients who were diagnosed with unilateral ADD were included in the study. In comparison to T0, the affected condylar height decreased 0.66 mm, whereas the non-affected condylar height increased 1.37 mm at T1. The further subgroup analysis revealed no statistically significant change in the affected condylar height of the 11-17 age group. However, a considerable reduction in height was observed on the ADD side in the subgroup above 18 years, when compared to the T0 period.
Conclusions: ADD disrupts the normal development of condylar bone and cartilage in all age groups. Clinician recognises that ADD results in condylar growth inhibition in the young and condylar resorption in the adult.
Performance of Molecular Culture ID in diagnosis of bacterial pericarditis
Authors: Bos Martine , Sánchez Maria Miguélez , Remijas Lauren , houdt robin van , peters edgar , Budding Dries
Published: January 2025

Bacterial pericarditis is a serious condition for which diagnosis relies on culture of the pericardial fluid. Culture often remains negative in cases of fastidious organisms or prior antibiotic treatment. To alleviate this issue, we developed Molecular Culture ID, an IVDR-approved, PCR-based pan-bacterial assay that identifies bacteria to the species level. Here, we evaluate the diagnostic accuracy of this test on a uniquely large sample set of 42 pericardial effusions. Molecular Culture ID identified 11 positive samples whereas culture detected only 7, demonstrating the promising potential of Molecular Culture ID to diagnose bacterial pericarditis.
Aktivierungspotenzial des Privatrechts für Zwecke des Klimaschutzes
Authors: Kraus Pauline
Published: January 2025

Ursprünglich richteten sich Klimaklagen gegen den Staat, der eine aus Sicht des Klägers unzureichende Klimapolitik betrieb. Nunmehr sind zunehmend auch private Energieproduzenten und Großemittenten in den Klägerfokus geraten. Dieser Aufsatz befasst sich mit der Frage, an welchen Stellen das Privatrecht, das grundsätzlich nicht der Verfolgung öffentlicher Interessen dient, für Zwecke des Klimaschutzes aktiviert werden kann. Schwerpunktmäßig wird hierfür das kaufrechtliche Mängelgewährleistungsrecht und das Deliktsrecht untersucht. Während sich das Kaufrecht sogar bei bloß vagen unternehmensbezogenen Bemühungszusagen als erfolgsversprechend erweist, wird die Analyse des Deliktsrechts zum Hürdenlauf. Sind die Hürden der Kausalität und Rechtswidrigkeit überwunden, so stellt sich erst das Kardinalproblem: deren prozessualer Beweis.
Art: The Spiritual Path to God
Authors: Sulaiman
Published: January 2025

Art has long been a means of expression that serves to create aesthetic works and as a spiritual path that connects the individual to the transcendental dimension and God. In Islam, art has a vital role as a medium for achieving closeness to God, where works such as calligraphy, geometric art, and mosque architecture serve as decoration and meditative and reflective means. The background of this research is the increasingly strong influence of materialism and commercialization in modern art, which has led to the loss of spiritual dimension in artworks. This article uses literature study methodologies and case studies to explore how art remains relevant as a spiritual path in traditional and modern contexts. In the literature study, the author examines works that discuss the relationship between art and spirituality in the Islamic tradition and the contribution of Islamic art in strengthening awareness of God. The results of this study show that although the modern art world is often focused on the commercial aspect, art still has excellent potential to be a spiritual means that can connect individuals with God, personally and collectively. Contemporary Islamic art, through digital technology and interactive media, has managed to create an immersive and immersive spiritual experience for its connoisseurs.
Philosophy at the St. Petersburg University. History and Traditions
Authors:   St. Petersburg State University, Kuznetsov Nikita V. , Osipov Igor D. ,   St. Petersburg State University
Published: January 2025

The article considers the peculiarities of the formation of philosophical education at the St. Petersburg University. During the period of the Academic University, Professors H. F. Gross and Strue de Pyrmont delivered the course of Natural Law. In the second half of the nineteenth century, philosophical education at the university was represented by a chair at the Faculty of History and Philology. A. I. Vvedensky, L. P. Karsavin, I. I. Lapshin worked at it in different years until 1917. The article emphasizes the scientific and pedagogical work of A. I. Vvedensky and his important role in the creation of the St. Petersburg Philosophical Society. The peculiarities of philosophical education after the foundation of the Philosophical Faculty at the Leningrad State University are also considered. It is argued that during that period the University became the center of philosophical education in the city. It is noted the important role of the Dean of the Faculty of Philosophy V. P. Tugarinov, V. G. Marakhov, Yu. V. Perov in the development of the Faculty of Philosophy, the scientific and pedagogical activities of V. Ya. Komarova, A. A. Galaktionov, P. F. Nikandrov, M. I. Shakhnovich, M. A. Kissel and others are noted. The post-Soviet period of philosophical education at the St. Petersburg University, associated with the activities of the Dean of the Faculty of Philosophy Yu. N. Solonin and the Director of the Institute of Philosophy S. I. Dudnik, is analyzed. The conclusion is made that there was formed important scientific and educational schools of study in the history of philosophy, logic and philosophy of science, Russian philosophy and culture, Eastern philosophy and culture, conflictology, philosophical anthropology and ethics, philosophy of religion and religious studies, museum affairs and monument protection. The special role of Ya. A. Slinin, B. V. Markov, K. S. Pigrov, B. I. Lipsky, E. V. Torchinov, Yu. V. Perov, S. I. Dudnik, B. G. Sokolov, E. G. Sokolov, A. M. Sokolov, A. F. Zamaleev, M. M. Shakhnovich, A. I. Strebkov, L. V. Shipovalova, T. G. Tumanyan, V. Yu. Perov, M. B. Piotrovsky in the formation of these schools is emphasized.
Byzantine Hesychasm: Luminosity and Transfiguration of the Human in the Uncreated Light
Authors:   RUDN University, Chistyakova Olga V. , Chistyakov Denis I. ,   RUDN University
Published: January 2025

The philosophical foundations of the Byzantine Hesychasm in the context of interrelationship between the human being and God in the uncreated Divine Light are taken under consideration. Some doctrines that precede the late Hesychasm and Gregory Palama and palamites’ teaching are analyzing in this sense. The forming of Hesychasm as a trend of the Byzantine thought is discussed in the article, starting from the early period of the Eastern Christian Empire’s history. The conceptions of Hermit Fathers (Evagrius Ponticus and Macarius of Egypt), John Climacus, Maximus the Confessor, Symeon the New Theologian, Gregory of Sinai are showed. The most important philosophical ideas of the Eastern Patristics are presented as a gradual emergence of the coherent mystical Christian doctrine of the Hesychasm. The authors pay a special attention to the reflection of the anthropological and epistemological provisions of Gregory Palama and his fellows’ theology which can be seen as a peculiar axiological space of the Late Byzantine’s culture. The peculiarity of the Hesychast religious gnosis is considered, being conveyed in Palama’s narrations of the ways of knowing God by a human through the uncreated Tabor light. The essence of the God-knowing process is reflected by the Byzantine thinker’s teaching about the transfigured nature of the human being, that has become perfect and deified due to the deep perception of the Divine light. The Hesychast Tabor light is a mean of the human and God’ spiritual unity, that converted a nature of an individual into luminous beginning. The transfiguration of the human, their luminosity “by the God’s grace” endow the human and God by a feature of comparability, however, incomparable with any other created being. The movement to the luminous transfiguration of the human is demonstrated as a twofold process—from God to the human and, vice versa, from the human to God, another word as a mutual activity of theosis and kenosis.