bluuebunny/crossref_metadata_2025 huggingface dataset:
Corrosion of Anodized Titanium Alloys
Authors: Jáquez-Muñoz Jesús Manuel , Gaona-Tiburcio Citlalli , Mendez-Ramirez Ce Tochtli , Carrera-Ramirez Martha Guadalupe , Baltazar-Zamora Miguel Angel , Santiago-Hurtado Griselda , Lara-Banda Maria , Estupiñan-Lopez Francisco , Nieves-Mendoza Demetrio , Almeraya-Calderon Facundo
Published: July 2024

Ti and Ti alloys are employed in demanding industries such as aerospace, automotive, biomedical, aeronautic, structural, naval, and chemical, thanks to their resistance to corrosion due to the formation of the TiO2 film on the surface. Diverse research has established that different corrosive media could attack the oxide layer. One way to generate a stable, compact, and continuous oxide film is through anodizing treatment. The efficiency of anodization depends on diverse factors such as the microstructure, chemical composition of alloys, pH of electrolyte, time, and temperature of anodizing. This review aims to examine the corrosion resistance of the anodized layer on Ti and Ti alloys, with different parameters. The discussion is centered on the influence of the different parameters and alloy properties in the effectivity of anodizing when they are characterized by electrochemical techniques while studying the behavior of oxide.
Mechanical Performance/Cost Ratio Analysis of Carbon/Glass Interlayer and Intralayer Hybrid Composites
Authors: Wu Weili
Published: July 2024

Hybrid composites combining carbon and glass fibers are increasingly studied for their potential to enhance mechanical properties and cost efficiency. Understanding how different hybrid structures influence these properties is critical for optimizing material design and application. In this paper, the mechanical properties of carbon/glass (C/G) interlayer and intralayer hybrid composites, including tensile, compressive, and flexural properties, were tested, and the cost performances of hybrid composites were analyzed to assess the economic feasibility of different stacking configurations. It was revealed that the specific tensile, compressive, and flexural modulus/cost and strength/cost ratios of interlayer and intralayer hybrid composites decreased with increasing carbon fiber content, indicating that adding carbon fiber reduced cost performance. With the combined hybrid ratio and the interlayer structure with glass fiber sandwiching carbon fiber, the tensile and compressive properties were the most cost-effective. When the dispersion degree of the intralayer hybrid structure was 0, the tensile and compressive properties were the most cost-effective. Specifically, for intralayer hybrid composites with a dispersion degree of 0 and C:G = 1:4, the specific tensile strength/cost ratio was 6.7 × 104 N·m/USD, and the specific compressive modulus and strength/cost ratio was 3.8 × 106 N·m/USD and 4.7 × 103 N·m/USD, respectively. However, the flexural performance/cost ratio was found to be opposite to the tensile and compressive results. When carbon fiber was distributed in the bottom layer or used to sandwich the glass fiber, the flexural performance/cost ratio of interlayer hybrid composites was nearly as good as that of glass fiber. Moreover, by considering the working condition of composites, the cost performance of mechanical properties can be optimized and improved through careful design of hybrid ratios and stacking structures.
A Comparative Study on Al0.6Ti0.4N Coatings Deposited by Cathodic Arc and HiPIMS in End Milling of Stainless Steel 316L
Authors: Saciotto Victor , He Qianxi , Guimaraes Monica C. , DePaiva Jose M. , Kohlscheen Joern , Fontana Luis C. , Veldhuis Stephen C.
Published: July 2024

The machining of austenitic stainless steel alloys is usually characterized by high levels of adhesion and built-up edge; therefore, improving tribological conditions is fundamental to obtaining higher tool life and better surface finish. In this work, three different Al0.6Ti0.4N coatings are compared, two deposited by Cathodic Arc Evaporation (CAE) and one with High-Power Impulse Magnetron Sputtering (HiPIMS). The effects of the micromechanical properties and the microstructure of the coatings were then studied and related to the machining performance. Both arc-deposited coatings (CAE 1 and 2) exhibited similar average tool life, 127 min and 128 min, respectively. Whereas the HiPIMS lasted for only 21.2 min, the HiPIMS-coated tool had a much shorter tool life (more than six times lower than both CAE coatings) due to the intense adhesion that occurred in the early stages of the tool life. This higher adhesion ultimately caused built-up edge and chipping of the tool. This was confirmed by the cutting forces and more deformation on the shear band and undersurface of the chips, which are related to higher levels of friction. The higher adhesion could be attributed to the columnar structure of the HiPIMS and the (111) main texture, which presents a higher surface energy when compared to the dominant (200) from both arc depositions. Studies focused on tribology are necessary to further understand this relationship. In terms of micromechanical properties, tools with the highest plasticity index performed better (CAE 2 = 0.544, CAE 1 = 0.532, and HiPIMS = 0.459). For interrupted cutting machining where adhesion is the main wear mechanism, a reserve of plasticity is beneficial to dissipate the energy generated during friction, even if this was related to lower hardness levels (CAE 2 = 26.6 GPa, CAE 1 = 29.9 GPa, and HiPIMS = 33.6 GPa), as the main wear mechanism was adhesive and not abrasive.
Effect of Temperature on the Structure and Tribological Properties of Ti, TiN and Ti/TiN Coatings Deposited by Cathodic Arc PVD
Authors: Ortega-Portilla Carolina , Giraldo Andrea , Cardona Jorge Andrés , Ruden Alexander , Mondragón Guillermo César , Trujillo Juan Pablo , Gómez Ortega Arturo , González-Carmona Juan Manuel , Franco Urquiza Edgar Adrián
Published: July 2024

Monolayers of Ti and TiN coatings, as well as a Ti/TiN bilayer coating, were deposited on AISI M2 steel substrates using the PVD cathodic arc technique. The coatings had a thickness close to 5 μm and an average roughness between 98.6 and 110.1 μm due to the presence of microdroplets on the surface. The crystalline structure of the materials was analyzed using Grazing Incidence X-ray Diffraction (GIXRD) with an increase in temperature to study the dynamics of oxide formation. A phase composition study was conducted using the Rietveld refinement method. At the temperatures where critical growth of titanium oxides, both anatase and rutile, was observed, pin-on-disk tests were performed to study the tribological properties of the materials at high temperatures. It was determined that the oxidation temperature of Ti is around 450 °C, promoting the formation of a combination of anatase and rutile. However, the formation of rutile inhibits the formation of anatase, which is stable above 600 °C. In contrast, TiN showed an oxidation temperature of 550 °C, with an exclusive growth of the rutile phase. The Ti/TiN bilayer exhibited mixed behavior, with the initial growth of anatase promoted by Ti, followed by the formation of rutile. Oxidation and tribo-oxidation dominated the wear behavior of the surfaces, showing a transition from mechanisms related to abrasion at low and medium temperatures to a combination of abrasion and adhesion mechanisms at high temperatures (800 °C).
Sol-Gel Derived ZnO Thin Films with Nonvolatile Resistive Switching Behavior for Future Memory Applications
Authors: Shen Xiangqian , Yu Zhiqiang
Published: July 2024

Herein we report on a facile sol-gel spin-coating technique to fabricate ZnO thin films that grow preferentially along the (002) plane on FTO substrates. By employing the magnetron sputtering technique to deposit a tungsten (W) top metal electrode onto these ZnO thin films, we successfully realize a W/ZnO/FTO memory device that exhibits self-rectifying and forming-free resistive switching characteristics. Notably, the as-prepared device demonstrates impressive nonvolatile and bipolar resistive switching behavior, with a high resistance ratio (RHRS/RLRS) exceeding two orders of magnitude at a reading voltage of 0.1 V. Moreover, it exhibits ultralow set and reset voltages of approximately +0.5 V and −1 V, respectively, along with exceptional durability. In terms of carrier transport properties, the low resistance state of the device is dominated by ohmic conduction, whereas the high resistance state is characterized by trap-controlled space-charge-limited current conduction. This work highlights the potential of the ZnO-based W/ZnO/FTO memory device as a promising candidate for future high-density nonvolatile memory applications.
Antibiotic Misuse during the COVID-19 Pandemic in Lebanon: A Cross-Sectional Study
Authors: Chaaban Taghrid , Ezzeddine Zeinab , Ghssein Ghassan
Published: July 2024

Background: Over the past 100 years, the discovery of antibiotics is regarded as one of the most significant advances in medical research and has saved millions of lives. However, the emergence of antimicrobial-resistant bacteria has significantly reduced the efficacy of antibiotics against infectious disorders. Antimicrobial resistance is mostly caused by antibiotic misuse for conditions that may be treated with self-care. During the COVID-19 pandemic, antibiotic use has been out of control among the general population. Aim: The objective of this study is to investigate the prevalence of antibiotic misuse during the COVID-19 pandemic in Lebanon. Methods: In January 2024, a descriptive cross-sectional study was conducted amongst students registered at the Islamic University of Lebanon. Individuals who have been infected with COVID-19 at least once were eligible for the study and were selected by a non-random snowball sampling technique. Descriptive and quantitative analyses were performed using SPSS 21. Results: Out of the 478 participants who completed the questionnaire, 40.2% (n = 192) received antibiotics during the COVID-19 infection. A physician’s prescription is mentioned by some participants (51%, n = 98), followed by a pharmacist’s (23.4%, n = 45), self-taken (14.5%, n = 28), and others as family or friends (10.9%, n = 21). Moreover, 59.3% (n = 114) of the respondents respected the antibiotic therapy’s rules, and 40.6% (n = 78) discontinued taking the antibiotic when they felt better. Conclusion: Our results showed that participants were likely to show unsatisfactory compliance and to use non-prescribed antibiotics. Campaigns are urgently needed to promote appropriate antibiotic use.
What Is Ailing Oncology Clinical Trials? Can We Fix Them?
Authors: Mittal Abhenil , Moore Sara , Navani Vishal , Jiang Di Maria , Stewart David J. , Liu Geoffrey , Wheatley-Price Paul
Published: July 2024

Evidence from phase three clinical trials helps shape clinical practice. However, a very small minority of patients with cancer participate in clinical trials and many trials are not completed on time due to slow accrual. Issues with restrictive eligibility criteria can severely limit the patients who can access trials, without any convincing evidence that these restrictions impact patient safety. Similarly, regulatory, organizational, and institutional hurdles can delay trial activation, ultimately making some studies irrelevant. Additional issues during trial conduct (e.g., mandatory in-person visits, central confirmation of standard biomarkers, and inflexible drug dosage modification) contribute to making trials non-patient-centric. These real-life observations from experienced clinical trialists can seem nonsensical to investigators and patients alike, who are trying to bring effective drugs to patients with cancer. In this review, we delve into these issues in detail, and discuss potential solutions to make clinical trials more accessible to patients.
Adjuvant Treatment of Stage I–II Serous Endometrial Cancer: A Single Institution 20-Year Experience
Authors: Akingbade Aquila , Fabi François , Cartes Rodrigo , Tsui James , Alfieri Joanne
Published: July 2024

Background: Serous endometrial carcinoma (SEC) is a high-risk subtype of endometrial cancer. The effectiveness of multiple adjuvant therapies, namely chemotherapy (CT), radiotherapy (RT), and sequential/concurrent chemotherapy with radiotherapy (CRT), have previously been investigated. However, optimal management of early-stage SEC remains unclarified. Methods: All cases of early-stage SEC (FIGO 2009 stages I–II) treated in our institution from 2002 to 2019 were identified. Patient data were documented until September 2023. Overall survival (OS) and disease-free survival (DFS) were computed using Kaplan–Meier estimates and Cox’s proportional hazard model; descriptive statistical analysis was performed. Results: A total of 50 patients underwent total hysterectomy-bilateral salpingo-oophorectomy and omentectomy, displaying stage IA (60%), IB (24%), and II (16%) disease. The median follow-up was 90.9 months. Patients underwent adjuvant CRT (n = 36, 72%), CT (n = 6, 12%), or RT (n = 6, 12%). Two patients were observed and excluded from analyses. The 42 patients who received radiotherapy had pelvic external beam radiotherapy (n = 10), vaginal brachytherapy (n = 21), or both (n = 11). CRT had better OS (HR 0.14, 95%CI 0.04–0.52, p < 0.005) and DFS (HR 0.25, 95%CI 0.07–0.97, p = 0.05) than CT alone. RT displayed no OS or DFS benefits compared to CT/CRT. Recurrences were mostly distant. Acute and late G3-4 toxicities were primarily hematologic. Conclusions: Our data underline the challenge of treating SEC. CRT appears to be superior to CT alone but not to RT. Most recurrences were distant, highlighting the need for optimized systemic treatment options.
Improving Care for Older Adults with Cancer in Canada: A Call to Action
Authors: Cook Sarah , Alibhai Shabbir , Mehta Rajin , Savard Marie-France , Mariano Caroline , LeBlanc Dominique , Desautels Danielle , Pezo Rossanna , Zhu Xiaofu , Gelmon Karen A. , Hsu Tina
Published: July 2024

Most patients diagnosed with and dying from cancer in Canada are older adults, with aging contributing to the large projected growth in cancer incidence. Older adults with cancer have unique needs, and on a global scale increasing efforts have been made to address recognized gaps in their cancer care. However, in Canada, geriatric oncology remains a new and developing field. There is increasing recognition of the value of geriatric oncology and there is a growing number of healthcare providers interested in developing the field. While there is an increasing number of dedicated programs in geriatric oncology, they remain limited overall. Developing novel methods to delivery geriatric care in the oncology setting and improving visibility is important. Formal incorporation of a geriatric oncology curriculum into training is critical to both improve knowledge and demonstrate its value to healthcare providers. Although a robust group of dedicated researchers exist, increased collaboration is needed to capitalize on existing expertise. Dedicated funding is critical to promoting clinical programs, research, and training new clinicians and leaders in the field. By addressing challenges and capitalizing on opportunities for improvement, Canada can better meet the unique needs of its aging population with cancer and ultimately improve their outcomes.
Current Advances in Radioactive Iodine-Refractory Differentiated Thyroid Cancer
Authors: Volpe Fabio , Nappi Carmela , Zampella Emilia , Di Donna Erica , Maurea Simone , Cuocolo Alberto , Klain Michele
Published: July 2024

Background: Differentiated thyroid cancer (DTC) patients have an outstanding overall long-term survival rate, and certain subsets of DTC patients have a very high likelihood of disease recurrence. Radioactive iodine (RAI) therapy is a cornerstone in DTC management, but cancer cells can eventually develop resistance to RAI. Radioactive iodine-refractory DTC (RAIR-DTC) is a condition defined by ATA 2015 guidelines when DTC cannot concentrate RAI ab initio or loses RAI uptake ability after the initial therapy. The RAIR condition implies that RAI cannot reveal new met-astatic foci, so RAIR-DTC metabolic imaging needs new tracers. 18F-FDG PET/CT has been widely used and has demonstrated prognostic value, but 18F-FDG DTC avidity may remain low. Fibroblast activation protein inhibitors (FA-Pi)s, prostatic-specific membrane antigen (PSMA), and somatostatin receptor (SSTR) tracers have been proposed as theragnostic agents in experimental settings and Arg-Gly-Asp (RGD) peptides in the diagnostic trial field. Multi-targeted tyrosine kinase inhibitors are relatively new drugs approved in RAIR-DTC therapy. Despite the promising targeted setting, they relate to frequent adverse-event onset. Sorafenib and trametinib have been included in re-differentiation protocols aimed at re-inducing RAI accumulation in DTC cells. Results appear promising, but not excellent. Conclusions: RAIR-DTC remains a challenging nosological entity. There are still controversies on RAIR-DTC definition and post-RAI therapy evaluation, with post-therapy whole-body scan (PT-WBS) the only validated criterion of response. The recent introduction of multiple diagnostic and therapeutic agents obliges physicians to pursue a multidisciplinary approach aiming to correct drug introduction and timing choice.
Quantitative Analysis of Different Foveal Avascular Zone Metrics in Healthy and Diabetic Subjects
Authors: Sijilmassi Ouafa
Published: July 2024

The primary aim of this study was to assess the size and shape of the Foveal Avascular Zone (FAZ) in patients with type 2 diabetes mellitus compared to healthy subjects. The study used 80 OCTA images from the FAZID dataset. The FAZ size was measured by its area, perimeter, and maximum/minimum Feret diameters. The shape was assessed using the axial ratio, circularity, roundness, and solidity. These metrics were calculated automatically using Matlab® R2020b. Statistical analysis was performed using SPSS statistical software version 28.0, with a p-value of less than 0.01 considered significant. The results showed that the FAZ area was significantly larger in diabetic eyes (mean = 0.50 mm2) compared to control eyes (mean = 0.37 mm2), with a p-value of less than 0.01. Both the maximum and minimum diameters of the FAZ were also significantly larger in diabetic groups compared to the control group. Parameters associated with FAZ’s shape were significantly smaller in the diabetic groups than in the control group, except for the axial ratio. The main finding of this study is that diabetic eyes without clinically detectable diabetic retinopathy exhibit morphological changes and irregularities at the FAZ border.
Real Implication of Fertility-Sparing Surgery for Ovarian Cancer: Reproductive Outcomes
Authors: Heras Marta , Alonso-Espias Maria , Arencibia Octavio , Minig Lucas , Marti Lola , Diestro Maria Dolores , Cespedes Juan , Niguez Isabel , Gil-Ibañez Blanca , Diaz-Feijoo Berta , Llueca Antoni , Rosado Claudia , Iacoponi Sara , Lopez de la Manzanara Carlos , Morales Sara , Fernandez-Galguera Maria Jose , Cano Ana , Gorostidi Mikel , Zapardiel Ignacio
Published: July 2024

Background: to prove the effectivity of fertility-sparing procedures in early-stage ovarian cancer by assessing pregnancy rates and obstetrical outcomes. Methods: we performed a retrospective multicenter study among 55 Spanish hospitals, collecting patients from 18 to 40 years old with diagnosis of early-stage ovarian cancer, epithelial (EOC) or non-epithelial (non-EOC), from January 2010 to December 2019. Data on the use of assisted reproductive techniques, pregnancy attempts and obstetrical outcomes were collected. Results: a total of 150 patients met inclusion criteria, 70 (46.6%) EOC and 80 (53.4%) non-EOC. Pregnancy attempts were reported in 51 (34%) patients, with 42 (28%) patients carrying the pregnancy to term. Among them, 30 (71.4%) underwent surgery alone and 12 (28.6%) had additional postoperative chemotherapy. A total of 32 (76.1% patients) had spontaneous pregnancies and 10 (23.9%) required in vitro fertilization. There was only one (2.4%) complication reported. Vaginal delivery was reported in twenty-nine (69%) patients and cesarean section in five (11.9%) patients. Conclusions: fertility-sparing management for ovarian cancer seems to be an option with proven good pregnancy rates and low complications. The selection of patients must consider strict criteria in order to maintain a good prognosis.
A Bi-Level Optimized Dispatching Method for Grids with High Penetration of New Energy Considering Ancillary Service Costs
Authors: Tao Renfeng , Li Fengting , Li Yangqing
Published: July 2024

To address the issue of high auxiliary service costs caused by the grid connection of new energy generation, a dual layer optimization scheduling method for high penetration new energy power grids is proposed, taking into account the auxiliary service costs of grid connection. The correlation between the output fluctuations and load fluctuations of new energy generation is analyzed, and a calculation model for auxiliary service costs caused by grid connection of new energy generation is established. Taking into account the timescale division requirements for grid energy trading and auxiliary service market transactions, a new high penetration energy grid two-level optimization scheduling model is established. The upper level scheduling model aims to minimize the sum of grid energy procurement costs and auxiliary service costs caused by new energy generation and completes the optimization scheduling of the grid for several hours. The lower level scheduling model aims to closely follow the upper level scheduling plan for new energy power plants/groups. Optimization and scheduling of the power grid for tens of minutes is completed, taking into account the balanced allocation of wind and solar losses among various power plants within the new energy power plant group. The simulation results show that the method proposed in this paper can reduce the energy transaction costs and auxiliary service transaction costs of the power grid during low and peak load periods.
Energy Consumption and Saved Emissions of a Hydrogen Power System for Ultralight Aviation: A Case Study
Authors: Donateo Teresa , Bonatesta Andrea , Ficarella Antonio , Lecce Leonardo
Published: July 2024

The growing concern about climate change and the contemporary increase in mobility requirements call for faster, cheaper, safer, and cleaner means of transportation. The retrofitting of fossil-fueled piston engine ultralight aerial vehicles to hydrogen power systems is an option recently proposed in this direction. The goal of this investigation is a comparative analysis of the environmental impact of conventional and hydrogen-based propulsive systems. As a case study, a hybrid electric configuration consisting of a fuel cell with a nominal power of about 30 kW, a 6 kWh LFP battery, and a pressurized hydrogen vessel is proposed to replace a piston prop configuration for an ultralight aerial vehicle. Both power systems are modeled with a backward approach that allows the efficiency of the main components to be evaluated based on the load and altitude at every moment of the flight with a time step of 1 s. A typical 90 min flight mission is considered for the comparative analysis, which is performed in terms of direct and indirect emissions of carbon dioxide, water, and pollutant substances. For the hydrogen-based configuration, two possible strategies are adopted for the use of the battery: charge sustaining and charge depleting. Moreover, the effect of the altitude on the parasitic power of the fuel cell compressor and, consequently, on the net efficiency of the fuel cell system is taken into account. The results showed that even if the use of hydrogen confines the direct environmental impact to the emission of water (in a similar quantity to the fossil fuel case), the indirect emissions associated with the production, transportation, and delivery of hydrogen and electricity compromise the desired achievement of pollutant-free propulsion in terms of equivalent emissions of CO2 and VOCs if hydrogen is obtained from natural gas reforming. However, in the case of green hydrogen from electrolysis with wind energy, the total (direct and indirect) emissions of CO2 can be reduced up to 1/5 of the fossil fuel case. The proposed configuration has the additional advantage of eliminating the problem of lead, which is used as an additive in the AVGAS 100LL.
A Two-Step Grid–Coordinate Optimization Method for a Wind Farm with a Regular Layout Using a Genetic Algorithm
Authors: Huang Guoqing , Chen Yao , Li Ke , Luo Jiangke , Zhang Sai , Lv Mingming
Published: July 2024

Currently, most studies on the optimization of wind farm layouts on flat terrain employ a discrete grid-based arrangement method and result in irregular layouts that may damage the visual appeal of wind farms. To meet the practical requirements of wind farms, a two-step optimization method called “grid–coordinate” based on a genetic algorithm is proposed in this paper. The core idea is to initially determine the number of wind turbines and their initial positions using a grid-based approach, followed by a fine-tuning of the wind farm layout by moving the turbines in a row/column manner. This two-step process not only achieves an aesthetically pleasing arrangement but also maximizes power generation. This algorithm is conducted to optimize a 2 km × 2 km wind farm under three classic wind conditions, one improved wind condition, and a real wind condition employing both the Jensen and Gaussian wake models. To validate the effectiveness of the proposed method, the optimization of configurations based on different wake models was conducted, yielding results including the efficiency, total power output, number of wind turbines, and unit cost of electricity generation. These results were compared and analyzed against the classical literature. The findings indicate that the unit cost of electricity generation using the two-step optimization approach with the Gaussian wake model is higher than that of the initial grid optimization method. Additionally, varying the number of wind turbines can lead to instances of high power generation coupled with low efficiency. This phenomenon should be carefully considered in the wind farm layout optimization process.
A Process Synthesis and Intensification Framework
Authors: Alcántara Avila Jesús Rafael , Villegas Uribe Cristopher Antonio , Herrera Velázquez Josué Julián , Cabrera Ruiz Julián
Published: July 2024

This Process Synthesis and Intensification (PS+I) framework uses a low-aggregation superstructure to solve the synthesis problem, and its solution is interpreted and translated into a task-integrated intensified process. Then, the process is post-optimized to find a better balance between operation and equipment costs. The solution leads to novel and counterintuitive intensified processes with low cost and energy requirements.
Assessing the Trade-off between Ecological Conservation and Local Development in Wuyishan National Park: A Production–Living–Ecological Space Perspective
Authors: Du Xishihui , Wang Zhaoguo , Wang Jingli , Liu Xiao
Published: July 2024

China’s national park establishment aims to achieve a balance between ecological conservation and regional development. This study adopts a production–living–ecological (PLE) space perspective to evaluate the park’s impact. By quantifying changes and employing a combination of geographic detector and coupling coordination degree analyses, this research explores the dynamics of habitat quality and PLE space within the Wuyishan region, alongside their interrelationships. The national park’s influence on the surrounding area exhibits spatial heterogeneity, evident both within and beyond park boundaries, as well as across different counties. Despite the concentration of PLE changes in the park’s vicinity, particularly in densely populated urban areas, the influence of the national park on the local area is random and primarily at a low level. Importantly, the ecological space exhibits substantial changes, mirroring improvements in habitat quality. Furthermore, the coupling coordination between habitat quality changes and PLE space changes exhibits remarkable spatial variations. The complex interrelationships among PLE space necessitate a coordinated approach to their development for effective national park management. Ultimately, this investigation provides a novel perspective for the assessment of Wuyishan National Park’s conservation effectiveness, contributing practical value for future endeavors.
Does Host-Guest Interaction Stimulate Tourists’ Citizenship Behavior? A Combination of Social Exchange Theory and Cognitive Appraisal Theory
Authors: Bi Juan , Wang Bingnan , Lu Feifei
Published: July 2024

This study delved into the intricate ways in which host-guest interaction influences tourist citizenship behavior (TCB), focusing specifically on two key dimensions: interaction quantity and interaction quality. By drawing on social exchange theory and cognitive appraisal theory, we constructed an integrated model that illustrates the relationship between host-guest interaction and TCB, with experiential value and place attachment serving as mediating factors. Our data were gathered from 499 visitors to Mount Taishan national forest park, and the analysis was conducted using Spss and Amos software. The results revealed that the quality of host-guest interaction has a significant and positive influence on tourists’ overall experiential value, which in turn fosters TCB. Additionally, the evaluation of experiential value triggers a deeper sense of place attachment among tourists towards the destination, further encouraging TCB. The quantity of host-guest interaction did not exert a significant influence on tourist citizenship behavior. These findings offer practical insights for destinations seeking to enhance their competitiveness and sustainability by optimizing host-guest interactions.
Exploring Gut–Brain Interaction Disorders: Mechanisms and Translational Therapies Crossing Neurology to Gastroenterology
Authors: Vasilev Georgi V. , Miteva Dimitrina , Gulinac Milena , Chervenkov Lyubomir , Kitanova Meglena , Velikova Tsvetelina
Published: July 2024

The bidirectional communication network between the gut and the brain, known as the gut–brain axis, plays a crucial role in health and disease. This review explores the mechanisms underlying gut–brain interaction disorders and highlights translational therapies bridging neurology and gastroenterology. Mechanisms encompass anatomical, endocrine, humoral, metabolic, and immune pathways, with the gut microbiota exerting profound influence. Clinical evidence links gut microbiota fluctuations to mood disorders, GI disruptions, and neurodevelopmental conditions, emphasizing the microbiome’s pivotal role in shaping brain–gut interactions. Pharmacological therapies such as amitriptyline and selective serotonin reuptake inhibitors modulate neurotransmitter activity, offering relief in functional gastrointestinal disorders like irritable bowel syndrome (IBS). Non-pharmacological interventions like cognitive–behavioral therapy and hypnotherapy address maladaptive thoughts and induce relaxation, alleviating gastrointestinal symptoms exacerbated by stress. Emerging therapies include gut microbiota modulation, dietary interventions, vagus nerve stimulation, and intestinal barrier modulation, offering novel approaches to manage neurological disorders via the gastrointestinal tract. Understanding and harnessing the gut–brain axis holds promise for personalized therapeutic strategies in neurogastroenterology.
Leonurine Exerts Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Endometritis by Modulating Mouse JAK-STAT/PI3K-Akt/PPAR Signaling Pathways
Authors: Shao Yongbin , Luo Yan , Sun Yaoqiang , Jiang Jingbo , Li Zhiyuan , Wang Zhen , Wang Mengmeng , Gu Xinli
Published: July 2024

Endometritis is a common disease in postpartum cows, characterized by delayed uterine recovery due to endometrial inflammation. Although antibiotics and hormones are commonly used, they have certain limitations. One potential alternative is using motherwort extract, specifically leonurine, which exhibits anti-inflammatory properties. However, leonurine’s exact molecular mechanism of action remains unclear. In this study, 40 mice were randomly divided into four groups: a control group, endometritis model group, LPS + leonurine group (30 mg/kg), and LPS + dexamethasone group (5 mg/kg). Transcriptomic analysis revealed that leonurine modulates multiple signaling pathways, including JAK-STAT/PI3K-Akt, and influences the expression of key genes, such as Prlr, Socs2, Col1a1, and Akt1. Furthermore, leonurine effectively reduces levels of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and IL-1β (p < 0.01), which play a crucial role in regulating acute endometritis. Additionally, leonurine helps maintain cholesterol homeostasis and attenuates inflammation through the peroxisome proliferator-activated receptor (PPAR) signaling pathway by modulating genes such as Cyp27a1, Hmgcs1, and Scd2. These findings suggest that leonurine has a protective effect against LPS-induced endometritis and that its anti-inflammatory properties involve multiple pathways and targets, which are potentially mediated by regulating signaling pathways such as JAK-STAT/PI3K-Akt and PPAR.
Overcoming Barriers: Strategies for Implementing Pharmacist-Led Pharmacogenetic Services in Swiss Clinical Practice
Authors: Wiss Florine M. , Jakober Deborah , Lampert Markus L. , Allemann Samuel S.
Published: July 2024

There is growing evidence that pharmacogenetic analysis can improve drug therapy for individual patients. In Switzerland, pharmacists are legally authorized to initiate pharmacogenetic tests. However, pharmacogenetic tests are rarely conducted in Swiss pharmacies. Therefore, we aimed to identify implementation strategies that facilitate the integration of a pharmacist-led pharmacogenetic service into clinical practice. To achieve this, we conducted semi-structured interviews with pharmacists and physicians regarding the implementation process of a pharmacist-led pharmacogenetic service. We utilized the Consolidated Framework for Implementation Research (CFIR) to identify potential facilitators and barriers in the implementation process. Additionally, we employed Expert Recommendations for Implementing Change (ERIC) to identify strategies mentioned in the interviews and used the CFIR-ERIC matching tool to identify additional strategies. We obtained interview responses from nine pharmacists and nine physicians. From these responses, we identified 7 CFIR constructs as facilitators and 12 as barriers. Some of the most commonly mentioned barriers included unclear procedures, lack of cost coverage by health care insurance, insufficient pharmacogenetics knowledge, lack of interprofessional collaboration, communication with the patient, and inadequate e-health technologies. Additionally, we identified 23 implementation strategies mentioned by interviewees using ERIC and 45 potential strategies using the CFIR-ERIC matching tool. In summary, we found that significant barriers hinder the implementation process of this new service. We hope that by highlighting potential implementation strategies, we can advance the integration of a pharmacist-led pharmacogenetic service in Switzerland.
Chronic Adolescent Restraint Stress Downregulates miRNA-200a Expression in Male and Female C57BL/6J and BALB/cJ Mice
Authors: Kamens Helen M. , Anziano Emma K. , Horton William J. , Cavigelli Sonia A.
Published: July 2024

Adolescence is a critical developmental period when the brain is plastic, and stress exposure can have lasting physiological consequences. One mechanism through which adolescent stress may have lasting effects is by altering microRNAs (miRNAs), leading to wide-scale gene expression changes. Three prior independent studies used unbiased approaches (RNA sequencing or microarray) to identify miRNAs differentially expressed by chronic variable stress in male rodents. In all three studies, miRNA-200a was differentially expressed in areas of the brain associated with emotion regulation. The current study extends this research to determine if chronic non-variable adolescent stress downregulates miRNA-200a expression by looking at two strains (BALB/cJ and C57BL/6J) of male and female mice. We utilized a 14-day (2 h/day) restraint stress protocol and verified stress effects on adolescent body weight gain and circulating corticosterone concentrations relative to non-restraint controls. Mice were then left undisturbed until they were euthanized in adulthood, at which time brains were collected to measure miRNA-200a in the ventral hippocampus. Three weeks after adolescent stress ended, differences in body weight between groups were no longer significant; however, animals exposed to stress had less miRNA-200a expression in the ventral hippocampus than control animals. These data implicate miRNA-200a expression as a potential mechanism by which adolescent stress can have persistent impacts on multiple outcomes in both male and female mice.
Sequencing and Description of the Mitochondrial Genome of Orthopodomyia fascipes (Diptera: Culicidae)
Authors: Silva Fábio Silva da , Nascimento Bruna Laís Sena do , Cruz Ana Cecília Ribeiro , Silva Sandro Patroca da , Aragão Carine Fortes , Dias Daniel Damous , Silva Lucas Henrique da Silva e , Reis Lúcia Aline Moura , Reis Hanna Carolina Farias , Chagas Liliane Leal das , Rosa Jr. José Wilson , Vieira Durval Bertram Rodrigues , Brandão Roberto Carlos Feitosa , Medeiros Daniele Barbosa de Almeida , Nunes Neto Joaquim Pinto
Published: July 2024

The genus Orthopodomyia Theobald, 1904 (Diptera: Culicidae) comprises 36 wild mosquito species, with distribution largely restricted to tropical and temperate areas, most of which are not recognized as vectors of epidemiological importance due to the lack of information related to their bionomy and involvement in the cycle transmission of infectious agents. Furthermore, their evolutionary relationships are not completely understood, reflecting the scarcity of genetic information about the genus. Therefore, in this study, we report the first complete description of the mitochondrial genome of a Neotropical species representing the genus, Orthopodomyia fascipes Coquillet, 1906, collected in the Brazilian Amazon region. Using High Throughput Sequencing, we obtained a mitochondrial sequence of 15,598 bp, with an average coverage of 418.5×, comprising 37 functional subunits and a final portion rich in A + T, corresponding to the control region. The phylogenetic analysis, using Maximum Likelihood and Bayesian Inference based on the 13 protein-coding genes, corroborated the monophyly of Culicidae and its two subfamilies, supporting the proximity between the tribes Orthopodomyiini and Mansoniini, partially disagreeing with previous studies based on the use of molecular and morphological markers. The information generated in this study contributes to a better understanding of the taxonomy and evolutionary history of the genus and other groups of Culicidae.
Characterization of Physiological and Biochemical Attributes of Neem (Azadirachta indica A. Juss) under Salinity Stress
Authors: Akram Muhammad , Sajid Zunera , Farooq Abu Bakr Umer , Ahmad Iftikhar , Jamal Aftab , Rizwana Humaira , Almunqedhi Bandar M. , Ronga Domenico
Published: July 2024

Salinity poses a significant threat to agricultural productivity worldwide, with its detrimental effects on plant growth and physiological processes. Understanding the mechanisms by which plants respond to salt stress is crucial for developing strategies to mitigate its impact on crop yield and sustainability. To address this issue, a pot study was conducted to determine the effect of salt stress on the physiological and biochemical attributes of neem (Azdiarchta indica A. Juss). Plants were grown for 10 months in pots filled with soil having different salinity levels of 3, 6, 9, 12, 15, and 18 dS m−1 and compared with a control of 1.7 dS m−1. The results showed that plant growth and chlorophyll contents declined as salinity levels increased. Due to oxidative stress, the contents of H2O2 increased under higher salt levels. The mitigation of oxidative stress was achieved through the activation of antioxidant enzymes (catalase, ascorbate peroxidase, peroxidase, and superoxide dismutase). Multivariate analysis indicated that Na+ accumulation in plants was positively related to H2O2 production and enzymatic activities, and negatively related to plant biomass, chlorophyll contents, root and shoot K+ concentration, and root K+/Na+. The experimental results suggest that neem plants can be grown in moderate saline soils.
Chromosome-Scale Genome Assembly Provides Insights into Fresh Pine Wood Decay Strategies of the Wolfiporia hoelen
Authors: Yang Chi , Xiao Donglai , Jiang Xiaoling , Li Yaru , Liu Xiaoyu , Lin Hui , Liu Chuansen , Ma Lu
Published: July 2024

The sclerotia of Wolfiporia hoelen (Fr.) Y.C. Dai & V. Papp is an important traditional Chinese medicine with diverse pharmacological properties. This study utilized a combination of PacBio Long-Read Sequencing, Illumina Short-Read Sequencing, and Hi-C Sequencing to generate a high-quality chromosome-level genome assembly of a W. hoelen strain Minling A5. There were 112 contigs in the genome, with 62.95 Mb in total length and 4.21 Mb in length for the contig N50. The average GC content was 51.89%. Based on Hi-C data, we corrected the CCS data and scaffolded them into 14 pseudo-chromosomes. The genome contained 44.37% repetitive sequences and 12,670 protein-coding genes, 86.53% (10,963) of which could be functionally annotated in at least one of the KOG, GO, Pfam, Swissprot, TrEMBL, NR, and KEGG databases. In addition, 240 transfer RNAs, 97 ribosomal RNAs, and 103 other non-coding RNAs were identified in the W. hoelen genome. A total of 755 pseudogenes were also identified, with an average length of 2665.51 bp. Further, there were 398, 100, 2837, 519, and 2068 genes annotated by CAZymes, TCDB, PHI, P450, and DFVF databases, respectively. One notable attribute of W. hoelen is its capacity to thrive in a substrate of fresh pine sawdust. Through an analysis of the growth on various pure wood sawdust culture media, we found that the growth of W. hoelen and Sparassis latifolia on pine sawdust was similar to that on broad-leaved wood sawdust, while the growth of Pleurotus ostreatus, P. eryngii, and Cyclocybe aegerita was slower than that on broad-leaved wood sawdust. By the functional annotation analysis of orthogroups in these five mushroom-forming fungi, it was determined that 645 orthogroups were specifically common in W. hoelen and S. latifolia. The genes in these specific orthogroups were significantly enriched in 12 pathways, including steroid biosynthesis, biosynthesis of antibiotics, and tyrosine metabolism. The high-quality genome and comparative genome analysis results significantly contribute to advancing our foundational knowledge of W. hoelen biology, while also offering valuable insights for the development of innovative biotechnological approaches aimed at enhancing the efficient and sustainable utilization of Pinus.
Investigation of Nursing Errors in Greek Pediatric Hospitals
Authors: Pappa Despoina , Evangelou Eleni , Koutelekos Ioannis , Dousis Evangelos , Toulia Georgia , Stavropoulou Areti , Margari Nikoletta , Giga Anna , Ferentinou Eftychia , Chasaki Konstantina , Bilali Aggeliki , Zartaloudi Afroditi , Dafogianni Chrysoula
Published: July 2024

Background: Adverse events are a prevalent occurrence across pediatric healthcare environments, and patient safety is intricately tied to nursing errors due to nurses’ consistent presence and interaction with patients, which surpasses that of any other healthcare professional. This research sought to explore the factors influencing errors as perceived by pediatric nurses in Greek hospital settings. Methods: Clinical pediatric nurses voluntarily and anonymously completed a specialized structured survey, utilizing the Taxonomy of Error, Root Cause Analysis, and Practice-responsibility (TERCAP) tool, which delineates the circumstances surrounding errors occurring during clinical practice. Results: Among the participants employed in the pediatric department, 80.8% (n = 84) reported experiencing an error at their workplace. Notably, in 48.7% (n = 38) of these instances, the error was attributed to themselves (personal responsibility), while in 78.9% (n = 56) of cases, it was linked to errors committed by other colleagues in the clinic. As reported by participants in pediatric departments, the primary factors contributing to potential error occurrence include the absence or inadequacy of orientation and training for new staff (43.2%), the absence of a standardized protocol for resolving disagreements (39%), insufficient ongoing training (38.3%), and breakdowns in interdisciplinary communication (21%). Conclusions: By classifying errors based on various criteria such as outcomes, processes, cognitive reasoning, ethical considerations, and importance, this study presents a holistic framework for examining pediatric nurses’ errors from diverse perspectives. Through this classification approach, the study establishes a foundation for tailored interventions targeting particular aspects of errors and their root causes in pediatric departments.
Estimation of Evapotranspiration in South Eastern Afghanistan Using the GCOM-C Algorithm on the Basis of Landsat Satellite Imagery
Authors: Wali Emal , Tasumi Masahiro , Klemm Otto
Published: July 2024

This study aims to assess the performance of the Global Change Observation Mission—Climate (GCOM-C) ETindex estimation algorithm to estimate the actual evapotranspiration (ETa) in southeastern Afghanistan. Here, the GCOM-C ETindex algorithm was adopted to estimate the monthly ETa for the period from November 2016 to October 2017 using a series of Landsat 8, Thermal Infrared Sensor (TIRS) Band 10 satellite imagery. The estimation accuracy was evaluated by comparing the results with other estimates of ETa, namely the mapping evapotranspiration with the internalized calibration (METRIC) model, the MODIS Global Evapotranspiration Project (MOD16), the surface energy balance system (SEBS) tools, and with the crop evapotranspiration under standard conditions (ETc) as estimated by the FAO-56 procedure. The evaluation was made for irrigated wheat, maize, rice, and orchards and for non-irrigated bare soil land. The comparison of ETa values showed good correlation among the GCOM-C, METRIC, and FAO-56, while the MOD16 and SEBS showed significantly lower values of ETa. The agreement with the METRIC ETa implies that the simple GCOM-C algorithm successfully estimated the ETa in the region and that the precision was similar to that of the METRIC. This study provides the first high-quality evapotranspiration data with the spatial resolution of Landsat Band 10 data for the southeastern part of Afghanistan. The estimation procedure is straightforward, and its results are anticipated to enhance the understanding of regional hydrology.