bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovery of molecular networks of neuroprotection conferred by Brahmi extract in Aβ42-induced toxicity model of Drosophila melanogaster using a quantitative proteomic approach
Authors: Deolankar Sayali Chandrashekhar , Najar Mohd Altaf , Ramesh Poornima , Kanichery Anagha , Kudva Avinash K. , Raghu Shamprasad Varija , Prasad T. S. Keshava
Published: June 2022

Accumulation of Aβ42 peptides forming plaque in various regions of the brain is a hallmark of Alzheimer’s disease (AD) progression. However, to date, there is no effective management strategy reported for attenuation of Aβ42 induced toxicity in the early stages of the disease. Alternate medicinal systems such as Ayurveda in the past few decades show promising results in the management of neuronal complications. Medhya Rasayana such as Brahmi is known for its neuroprotective properties via resolving memory-related issues, while the underlying molecular mechanism of the same remains unclear. In the present study, we aimed to understand the neuroprotective effects of the aqueous extract of Bacopa monnieri and Centella asiatica (commonly known as Brahmi) against the Aβ42 expressing model of the Drosophila melanogaster. By applying a quantitative proteomics approach, the study identified > 90% of differentially expressed proteins from Aβ42 expressing D. melanogaster were either restored to their original expression pattern or showed no change in expression pattern upon receiving either Brahmi extract treatment. The Brahmi restored proteins were part of neuronal pathways associated with cell cycle re-entry, apoptosis, and mitochondrial dynamics. The neuroprotective effect of Brahmi was also validated by negative geotaxis behavioral analysis suggesting its protective role against behavioral deficits exerted by Aβ42 toxicity. We believe that these discoveries will provide a platform for developing novel therapeutics for AD management by deciphering molecular targets of neuroprotection conferred by an aqueous extract of Bacopa monnieri or Centella asiatica.
Influence of social, demographic, and clinical factors in live births with spinal dysraphism in Brazil: an ecological study of 21 years
Authors: Oliveira Raissa Tereza Casseb , Dantas Diego Bessa , de Andrade Edila Monteiro , Affonso Márcio Vinicius de Gouveia , de Marin Ana Beatriz Rocha , Gomes Fabiana de Campos , Gonçalves Nelson Veiga , de Melo-Neto João Simão
Published: June 2022

Objectives: This study aimed to verify possible associations between sociodemographic and clinical factors in live births with spinal dysraphism .Methods: An analytical (descriptive and inferential), ecological study was carried out based on secondary data of 11,308 live births with spinal dysraphism registered in the Live Birth Information System (SINASC) in Brazil from 1999 to 2019. Demographic factors analyzed were age, education, mothers' marital status and geographic region. The clinical factors analyzed were duration, gestation period, birthweight and number of prenatal visits performed by women who underwent medical follow-up.Results: There was an increase in the number of cases of spinal dysraphism in recent years in Brazil with an annual percentage variation of 3.52%. However, the period from 2005 to 2009 showed a reduction in live births with spinal dysraphism . The regions with the highest incidence were the South and Southeast. The risk increased in mothers born after 1980, older than 30 years and with a high level of education. The risk was increased in live births of whites and blacks, born from double pregnancy and with body weight less than 3,000 g. The absence of prenatal care was associated with a higher incidence.Conclusion: Sociodemographic and clinical factors have specific characteristics that can predict spinal dysraphism in newborns in Brazil.
Acute Headache Management for Patients with Subarachnoid Hemorrhage: An International Survey of Healthcare Providers
Authors: Maciel Carolina B. , Barlow Brooke , Lucke-Wold Brandon , Gobinathan Arravintha , Abu-Mowis Zaid , Peethala Mounika Mukherjee , Merck Lisa H. , Aspide Raffaele , Dickinson Katie , Miao Guanhong , Shan Guogen , Bilotta Federico , Morris Nicholas , Citerio Giuseppe , Busl Katharina M.
Published: June 2022

Background: Severe headaches are common after subarachnoid hemorrhage (SAH). Guidelines recommend treatment with acetaminophen and opioids, but patient data show that headaches often persist despite multimodal treatment approaches. Considering an overall slim body of data for a common complaint affecting SAH patients during their intensive care stay, we set out to assess practice patterns in headache management among clinicians who treat patients with SAH.Methods: We conducted an international cross-sectional study through a 37-question web-based survey distributed to members of 5 professional societies relevant to intensive and neurocritical care from 11/2021-1/2022. Responses were characterized through descriptive analyses; Fisher’s exact test was used to test associations.Results: Of 516 responses, 329/497 (66%) were from North America and 121/497 (24%) from Europe. 379/435 (87%) reported headache as major management concern for SAH patients. Intensive-care-teams were primarily responsible for analgesia during hospitalization (249/435, 57%), while responsibility shifted to neurosurgery at discharge (233/501, 47%). Most used medications were acetaminophen (90%), opioids (66%), corticosteroids (28%) and antiseizure medications (28%). Opioids or medication combinations including opioids were most frequently perceived as most effective, by 169/433 (39%, predominantly intensivists), followed by corticosteroids or combinations with corticosteroids (96/433, 22%, predominantly neurologists). Of medications prescribed at discharge, acetaminophen was most common (303/381, 80%), followed by opioids (175/381 [46%]), and antiseizure medications (173/381, 45%). Opioids during hospitalization were significantly more prescribed by intensivists, by providers managing higher numbers of SAH patients, and in Europe. At discharge, opioids were more frequently prescribed in North America. 299/435 (69%) indicated no change in prescription practice of opioids with the opioid crisis. Additional differences in prescription patterns between continents and providers, and inpatient versus discharge were found. Conclusions: Post-SAH headache in the intensive care setting is a major clinical concern. Analgesia heavily relies on opioids both in utilization and in perception of efficacy, with no reported change in prescription patterns for opioids for most providers despite the significant drawbacks of opioids. Responsibility for analgesia shifts between hospitalization and discharge. International and provider-related differences are evident. Novel treatment strategies and alignment of prescription between providers are urgently needed.
Exploration of diet quality predictors in early care and education centers
Authors: Davis EN , Pavela G , Fernandez JR , Jones PA , Evans R , YE Cedillo , Bertrand B
Published: June 2022

Background: Over 75% of children ages 2-5 years attend Early Care and Education (ECE) centers, where they consume most of their daily caloric intake. This study sought to identify characteristics of ECE centers such as the state licensure, facility type (if centers are part of a local religious church or are not; faith-based or center-based, respectively), household income, monthly tuition, if cook taught in the classroom, daily attendance, hours children spent at the center, access to foods, menu substitutions, and who develops the menu; characteristics that predict the diet quality of menus as prepared by the center, the quality of meals served by the center, and discrepancies in diet quality between the menu and what was served.Methods: This observational study assessed associations between center characteristics and diet quality using menu collection and visual observation of food/beverages. Healthy Eating Index-2015 (HEI) scores were calculated for food/beverages listed on menus (HEI_MENU), served to children (HEI_SERVED), and differences between MENU and SERVED (HEI_M-S). Multiple linear regression identified predictors of MENU, SERVED, and M-S.Results: 53 centers were included, 68% (n=36) center-based and 32% (n=17) faith-based. Of the ECE centers analyzed, 75% held Alabama licensure and 58% participated in Child and Adult Care Feeding Program. The HEI scores of ECE menus were associated with facility type, such that center-based ECEs had higher HEI scores compared to faith-based centers (p=0.04). Center-based ECEs showed a menu HEI mean score of 62.4 ± 11.0 and served HEI score of 56.3 ± 12.2. No additional center characteristics were associated with measures of dietary quality. Conclusions: Facility type was identified as a preliminary predictor of menu diet quality. In Alabama, center-based ECEs are required to be licensed and meet the Food Nutrition Services (FNS) meal pattern guidelines. For faith-based ECEs, licensure is optional, so they face fewer regulations to meet the FNS meal pattern guidelines. Additional research should explore licensure as a potential mediator between facility type and HEI_MENU diet quality.
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis
Authors: Peng Tingwei , Liu Mingchuan , Hu Lang , guo Dong , Wang Di , Qi Bingchao , Ren Gaotong , Hu Chenchen , Zhang Feng , Chun Hyung J. , Hu Jianqiang , Song Liqiang , Li Yan
Published: June 2022

Background
Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetic cardiomyopathy (DCM), leading to early impaired myocardial compliance and late heart failure. However, the underlying mechanism remains largely unclear. This study aims to investigate the role of LncRNA Airn in the pathogenesis of cardiac fibrosis in DCM and its underlying mechanism.
Methods
Diabetic mellitus were induced by streptozotocin (STZ) injection. Intramyocardial adeno-associated virus (AAV) was employed to manipulate Airn expression. Multiple approaches including echocardiography, m6A-RNA immunoprecipitation, RNA pull-down and RNA-FISH staining were performed in-vivo and in-vitro.
Results
Airn was significantly lower in the hearts of diabetic mice, accompanied by evident cardiac dysfunction. AAV-mediated Airn overexpression restored cardiac function and prevented cardiac fibrosis in diabetic mice. During the in-vitro experiments, Airn exerted its anti-fibrogenesis effects in HG-treated cardiac fibroblasts (CFs) by reducing the expression of cardiac fibrotic markers and inhibiting CFs proliferation. Mechanistically, RNA pull-down and RIP assays indicated that Airn bond to insulin-like growth factor 2 mRNA-binding protein2 (IMP2) and prevented its ubiquitination-dependent degradation. Further analyze revealed Airn/IMP2 identified the m6A modification in p53 mRNA and protected p53 mRNA from degradation, leading to CFs cell cycle arrest and reduced cardiac fibrosis. In contrast, Ablation of p53 blunted the inhibitory effects of Airn on fibroblasts activation.
Conclusions
Our study demonstrated for the first time that LncRNA Airn prevented the development of cardiac fibrosis in diabetic heart via a m6A-IMP2-p53 axis. LncRNA Airn could be a promising therapeutic target for cardiac fibrosis in DCM.
MaMiPot: A Paradigm Shift for the Classification of Imbalanced Data
Authors: Zefrehi Hossein Ghaderi , Altınçay Hakan
Published: June 2022

The most frequently used approach for imbalance learning is resampling. In this technique, the minority class is oversampled. Most of the algorithms used for this purpose are variants of the well-known algorithm named as SMOTE, which is based on creating synthetic samples on the lines connecting selected minority instances. The variants are mainly designed to alleviate the shortcomings of SMOTE where, the idea of generating synthetic samples to avoid the bias on the majority class is preserved. This study aims at following a different path. Instead of balancing, the proposed approach is based on repositioning the samples. In particular, the classifier is enforced to learn the decision regions of the minority class by repositioning the majority class samples. Consequently, the regions in which positive instances exist will not be outnumbered the majority class samples. Hence the classifier labels these regions as the minority class. To tackle the noisy instances, the minority samples are repositioned, but only slightly to avoid distorting the original distribution. The potential of the proposed repositioning scheme is also evaluated as a preprocessing algorithm for SMOTE. The experiments that are conducted on 52 datasets from the KEEL repository have shown that the proposed approach is highly effective, when evaluated in terms of F-score, G-mean and AUC.
Experimental study on liquid sloshing of a vane type surface tension tank for satellite
Authors: Liu Jintao , Li Yong , Li Wen , Qu Zhen , Cai Kun , Chen Lei , Yang Nanji
Published: June 2022

Experiment research on liquid sloshing performance of a vane type tank used in high orbit satellite is carried out. The liquid sloshing tests of the tank without propellant management device (PMD) are developed under different liquid filling ratios. Experimental test results are in good agreement with theoretical results, which shows the reliability of test system. Liquid sloshing tests of the tank with PMD are performed with different directions and liquid filling ratios. There has a linear relationship between sloshing frequency and liquid filling ratio of vertical installation test when the liquid-gas interface is in the hemisphere. When the gas-liquid interface is in the cylindrical section, the sloshing frequency of vertical installation test remains basically unchanged. The inverted conical accumulator structure of PMD can increases the damping in the tank of vertical installation. The sloshing mass for vertical direction is less than the result of horizontal direction. Liquid sloshing results of the vane type propellant tank will provide a guidance for the design of spacecraft structure and control system.
Transcriptional activation of Mink Enteritis Virus VP2 by the C-terminal of MEV NS1 protein
Authors: Xie Qianqian , Wang Jigui , Liu Ying , Su Jun , Gu Chenchen , Wu Jing , Xiao Jun , Liu Weiquan
Published: June 2022

Mink enteritis virus (MEV) NS1 is a multidomain and multifunctional protein containing origin binding, helicase and transactivation domains. In particular, parvoviral NS1 proteins are transactivators of the viral capsid protein promoter although the manner by which they exert these transactivation effects remained unclear. In this study, the region of the transactivation domain of the NS1 C-terminal was found located at aa 557 ~ 668 and any deletion within this region reduced the transactivation activity. A dominant negative mutation of the 63 aa deletion in the C-terminal of NS1 protein resulted in loss of ability to activate P38 and VP2-5’UTR in a dual-luciferase reporter assay system, a VP2 protein expression system, and within the whole MEV genome, independent of downstream genes. Additionally, a full-length MEV clone deficient in its NS1 C-terminal failed to rescue the virus, possibly due to the loss of integrity of DNA sequences interacting with NS1 protein, and expression of VP2 was also inhibited even when normal NS1 protein was supplied in trans.
Construction of high density genetic map and QTL mapping in a sorghum Tx623A×sudangrass S722 population
Authors: Tu Wenmiao , Wang Lihua , Jin Peng , Meng Ruirui , Zheng Jian , Liu Yanlong , Wang Yi-Hong , Li Jieqin
Published: June 2022

Sorghum-sudanense is a hybrid of sorghum and Sudanese grass and is widely used in animal husbandry and aquaculture because of its high yield, excellent quality and wide adaptability. Its total fresh biomass yield, fresh biomass yield at each cut and nutritional quality are better than their parents. Using high-throughput sequencing, we constructed a high-density genetic map of sorghum Tx623A×sudangrass S722 with 103 recombinant inbred lines (RIL) in this study and mapped quantitative trait loci (QTLs) for plant height (PH), stem diameter (SD), tiller number (TN), fresh weight (FW) and dry weight per plant (DW). The map included 1,610 markers with a total length of 2,329 cM and QTL mapping identified 19 QTLs, including two for PH, three for SD, four for TN, four for FW and five for DW. We detected two QTL clusters containing overlapping QTLs for PH, FW and DW. Orthologs of three SD candidate genes from maize were found within two SD QTLs. The identification of these QTLs will be useful for dissecting important traits and developing marker-assisted selection (MAS) in future sorghum breeding programs.
Enhanced oil-spill removal and recovery from water bodies using diatomaceous earth and C18-silane grafted polyurethane
Authors: Perera Helanka J. , Goyal Anjali , Banu Hussaina , Alhassan Saeed M.
Published: June 2022

This research focuses on novel synthesis of polyurethane (PU) foam surface functionalized with diatomaceous earth (DE) particles and non-fluoro octadecylsilane (C18), intended to improve the hydrophobicity and wettability of the PU foam, in order to evaluate its potential use in enhanced clean-up of oil spill contaminants from water. The modified PU foam has been characterized by scanning electron microscopy to understand the microstructural changes during the surface modifications, Fourier transform infrared spectroscopy to track the integration of functional groups, X-ray Crystallographic study to indicate the increase in the crystallinity of the resultant foam due to the incorporation of silane and thermogravimetric analysis to understand the thermal stability and to calculate the thermal mass loss during the chemical modification. Furthermore, to test the enhanced hydrophobicity and oil spill clearance from water, the water contact angle has been measured and crude oil absorption capacity has been tested. The results show increased water repellency attributed to the strong hydrophobicity, and about 2.13 folds of increased crude oil absorption in comparison to the unmodified PU foam. Hence, the results collectively suggest the use of the synthesized surface-modified PU foam with superior hydrophobicity, water repellence and surface wettability as a potential candidate for enhanced crude oil absorption from water bodies.
Private Anomaly Detection of Student Health Conditions based on Wearable Sensors in Mobile Cloud Computing
Authors: Xie Yu , Zhang Kuilin , Kou Huaizhen , Mokarram Mohammad Jafar
Published: June 2022

With the continuous spread of COVID-19 virus, how to guarantee the healthy living of people especially the students who are of relative weak physique is becoming a key research issue of significant values. Specifically, precise recognition of the anomaly in student health conditions is beneficial to the quick discovery of potential patients. However, there are so many students in each school that the education managers cannot know about the health conditions of students in a real-time manner and accurately recognize the possible anomaly among students quickly. Fortunately, the quick development of mobile cloud computing technologies and wearable sensors has provided a promising way to monitor the real-time health conditions of students and find out the anomalies timely. However, two challenges are present in the above anomaly detection issue. First, the health data monitored by massive wearable sensors are often massive and updated frequently, which probably leads to high sensor-cloud transmission cost for anomaly detection. Second, the health data of students are often sensitive enough, which probably impedes the integration of health data in cloud environment even renders the health data-based anomaly detection infeasible. In view of these challenges, we propose a time-efficient and privacy-aware anomaly detection solution for students with wearable sensors in mobile cloud computing environment. At last, we validate the effectiveness and efficiency of our work via a set of simulated experiments.
Inadequate Proximal Screw Fixation Increases Risk of Failure Following Plate Fixation of Diaphyseal Humerus Fractures
Authors: Mistry Manisha , Tat Jimmy , Husain Rafi , Richards Robin , Sheth Ujash , Nam Diane
Published: June 2022

Background: Operative treatment of humeral shaft fractures (AO/OTA 12) is being performed more frequently. Accordingly, it is important to understand the complications associated with operative fixation. This study analyzes risk factors associated with mechanical failure following plate fixation of humeral shaft fractures in order to further elucidate the mode and location of failure. Methods: A retrospective review of 351 humeral shaft fractures was completed at a single level I trauma center. Eleven of eighty-five humeral shaft fractures had aseptic mechanical failure requiring revision (12.9%), following initial plate fixation. Fracture characteristics (AO type, comminution, location) and fracture fixation (plate type, multiplanar, number of screws proximal and distal to the fracture) were compared between aseptic mechanical failure and those without failure. A forward stepwise logistic regression analysis was performed to determine any significant predictors of aseptic mechanical failure.Results: There was significant differences in fixation between the aseptic mechanical failure group and those without failure, specifically in the number of screws for proximal fixation (p=0.008) and distal fixation (p=0.040). In the aseptic mechanical failure group, patients tended to have less than <8 cortices of proximal fixation (82%) and less than <8 cortices of distal fixation (64%). Conversely, in patients without mechanical failure there was a tendency to have greater than >8 cortices in both the proximal (62%) and distal fixation (70%). A forward stepwise logistic regression analysis found that less than <8 cortices of proximal fixation was a significant predictor of aseptic failure, OR 7.96 (P = 0.011). We think this can be accounted for due to the variable bone quality, thinner cortices and multiple torsional forces in the proximal shaft that may warrant special consideration for fixation.Discussion: The current dogma of humeral shaft fracture stabilization is to use a minimum of 3 screws proximal and distal to the fracture, however the current study demonstrates this is associated with higher rates of mechanical failure. In contrast, constructs with 4 bicortical screws or more of fixation on either side of the fracture had lower failure rates and may help to reduce the risk of mechanical failure. Level of Evidence: Level III
A symmetric-difference-closed orthomodular lattice that is stateless
Authors: Voráček Václav , Pták Pavel
Published: June 2022

This paper carries on the investigation of the orthomodular lattices that are endowed with a symmetric difference. Let us call them ODLs. Note that the ODLs may have a certain bearing on “quantum logics”-the ODLs are close to Boolean algebras though they capture the phenomenon of non-compatibility. The initial question in studying the state space of the ODLs is whether the state space can be poor. This question is of a purely combinatorial nature. In this note, we exhibit a finite ODL whose state space is empty (respectively, whose state space is a singleton).
Adaptive Control for the Nonlinear Event-triggered Networked Control System: A Decoupling Method
Authors: He Chao , Liu Sanyang , Li Junmin , Wang Jiaxian
Published: June 2022

In this paper, the adaptive control for a kind of nonlinear system over the event driven sensors-controller communication network is addressed. Over this network, the existing strategy has been developed. However, the event-triggered mechanism and adaptive estimators are coupled together which results in extra information delivery of the adaptive estimators over the network or extra computation equipment on the sensor side. To overcome this limitations, two kinds of adaptive control strategies are proposed in this paper. At first, the control strategy with the new event-triggered adaptive estimator is developed for the system without external disturbances where the event-triggered mechanism doesn't need the information of the adaptive estimators. It is proved that the closed-loop system is asymptotically stable and the Zeno behaviour is excluded. Furthermore, for the system with external disturbances, a robust control scheme with modified adaptive estimator and event-triggered mechanism is proposed and the practical stability of the closed-loop system is guaranteed. Also, the Zeno behaviour is excluded carefully. Comparing with the existing results, due to the decoupling structure of event-triggered mechanism and adaptive estimators, it is unnecessary to transfer the estimators' information to the event-triggered mechanism on the sensor side which saves the communication cost. What's more, although the system state is sampled and event driven, the asymptotical stability is still guaranteed. Also, the developed strategy can handle with the external disturbances. Finally, two examples are performed to illustrate the effectiveness of the schemes and some comparisons are displayed to explain the advantages of the methods.
Diagnostic accuracy of pleural effusion hyaluronic acid for malignant pleural mesothelioma: A systematic review and meta-analysis
Authors: Okuno Takehiro , Shiroshita Akihiro , Shibata Yusaku , Ishida Koichi , Suzuki Hokuto , Nakashima Kiyoshi , Mutrata Yasunori , Takeshita Masafumi
Published: June 2022

Background
The diagnosis of malignant pleural mesothelioma (MPM) is generally difficult, and no single biomarker has been established. Hyaluronic acid (HA) is highly elevated in MPM and could thus be a diagnostic biomarker. However, to our best knowledge, no systematic review has evaluated the diagnostic accuracy of pleural HA. This systematic review aimed to evaluate the diagnostic accuracy of pleural effusion HA for MPM.
Methods
We searched MEDLINE via OVID, Embase via Embase.com, Central, and the International Clinical Trials Registry Platform databases for relevant articles. Prospective, retrospective, and case-control studies that assessed the sensitivity and specificity of pleural effusion HA for MPA diagnosis were included. The exclusion criteria were review articles, case reports, and animal studies. The quality of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Forest plots were generated to summarize the sensitivity and specificity of HA in each included study. In addition, the pooled sensitivity and specificity of HA for MPA diagnosis was calculated using a bivariate random effects model.
Results
Overall, 6 studies involving 1,548 patients were included. There was a high risk of bias because 83% of the included studies had a case-control design. The pooled sensitivity and specificity were 50% (95% CI: 40–59%) and 97% (95% CI: 93–99%), respectively. We could not obtain a reliable estimate of the 95% confidence region or 95% prediction region because of the small sample sizes of the included studies.
Conclusions
Although HA in pleural effusion might have low sensitivity and high specificity for MPM diagnosis, we could not draw a valid conclusion because of the high risk of bias and small sample size. Further large-scale retrospective cohort studies are needed to more accurately estimate its sensitivity and specificity.
Single Cell Genetic Analysis of COVID-19: A Deep Learning Approach
Authors: Schonfeld Elan
Published: June 2022

COVID-19 was declared by the World Health Organization in 2020 to be a pandemic. Analysis of COVID-19 related genetic pathways allows for a better understanding of the possible effects and sequelae of the disease. Using 6178 scRNA sequenced human cells, having a status of control/mild/severe COVID-19 disease status, differential expression of genes and pathways was analyzed. Using Gene Set Enrichment Analysis (GSEA), mild COVID-19 was found to over-express the Influenza Pathway. In order to identify genes important in COVID-19 severity, a deep learning classifier was trained. Classifiers were repeatedly trained for this task using 10 randomly selected genes from the total number of 18,958 genes. The highest performing classifier (AUC=0.748) was trained using: AC008626.1, SGO1, RHOBTB2, RBM41, NDUFAF4P1, COX5A, ZDHHC17, STX11, IPP, NUDT5 genes. These results further illustrate the other factors contributing to mild versus severe COVID-19, as well as evidence of potential misdiagnosis or overlapping pathway effects of Influenza and COVID-19.
Assessment of Mental Health and Quality of Life among University Students during Covid-19 Pandemic in Malaysia, 2021
Authors: Kyaw Thin Mon Kyaw , Khiruddin Adhwa Husna Binti Muhammad Khiruddin Muhammad , Zulkarnain Amirul Mukmin Bin Muhamad Zulkarnain Muhamad , Hamzah Trisya Amanda Bt Hamzah , Ibrahim Aisyah Nurlyana Bt Ibrahim
Published: June 2022

Background
This research is conducted to know Malaysian university student’s mental health status and their quality of life during this COVID-19 pandemic in Malaysia, 2021. This study aims to associate sociodemographic background, paranoia level and resilience level with quality life. Quality of life is the general well-being of individuals whereas paranoia is the thought process that causes irrational suspicion or mistrust, and resilient is the ability of an individual able to adapt in faced the trouble.
Methods
The study was carried in the form of questionnaire that consisted of items on sociodemographic information, paranoia and resilience level and quality of life status. Sample population of 653 respondents were collected from both private and public universities. Data were later analyzed in frequencies and percentages, Chi-square test and as well as binary logistic regression (BLR).
Results
We found that the relation between QOL with resilience and paranoia. Normal (AOR 2.55) and high resilience (AOR = 2.75) people showing have higher quality of life while people with severe Paranoia (AOR 0.538) were less likely to have good Quality of life than those who reported with moderate paranoia. The most significant result indicates that high levels of resilience was associated with good QoL while student with moderate to severe paranoia will have low QoL.
Conclusion
As a result, university students from different sociodemographic background with high resilience and low paranoia level will have good quality of life. This study recommends future study to consider and investigate external factors that could affect this study’s outcome.
Using β-galactosidase and Novel Probiotic Strains to Formulate Lactose-Free Acidophilus Milk Fortified with Cocoa Powder
Authors: Islam Md Zakirul , Akhter Sharmin , Liza Ruckshana Islam , Sojib Md. Shahriar Islam , Hasan Md. Sayed , Habib Raihan , Harun-ur-Rashid Md.
Published: June 2022

The study was investigated to develop the lactose-free probiotic acidophilus milk (PAM) enriched with novel probiotic strains (Lactobacillus acidophilus LDMB01, Lactococcus lactis LDMB10, and Streptococcus thermophilus LDMB09), as well as fortified with cocoa powder. The physicochemical, microbiological, and sensory analyses were performed to see how the formulations worked. Two probiotic acidophilus milk formulations were made with β-galactosidase lactose hydrolysis, one with cocoa (5% m/v). A constant sugar level of 5% was used. The lactose-free acidophilus milk did not differ in acid content and showed values below 0.1% for lactose. The incorporation of cocoa in the PAM provided higher initial pH values reduced with the storage period and higher syneresis values throughout 28 days of storage. In addition, the probiotic bacteria showed high viability during storage, with counts above 7 log CFU/mL. In terms of sensory evaluation, most judges assigned both products an overall acceptability score of 8 for the characteristics (appearance, aroma, taste, texture, and overall acceptance). On the other hand, the sample containing cocoa achieved higher mean scores for appearance and texture. As a result, these products have much potential for industrial use, especially for lactose-intolerant people.
Laughable borders: Making the case for the humorous in migration studies
Authors: Franck Anja
Published: June 2022

Humor is widely recognized as a fundamental aspect of the human experience, that has also played a vital role in the way marginalized groups comment on and mock power. Yet, in migration research the methodological and analytical value of humor has been largely overlooked. Rather, migration studies has commonly centered its analysis around suffering and tragedy and, in the process, depicted migrant trajectories as endeavors largely devoid of laughter, humor, irony and play. This article suggests that such humorless representations of the migration process – and indeed of the migrant subject itself – has broader implications for the types of knowledge that we (re)produce around migrants’ experiences, subjectivities and struggles. In fact, it argues that migration studies’ failure to recognize migrants as humorous individuals risks feeding into processes of exceptionalization and de-humanization through setting “the migrant” up as an obscure figure that lacks “essentially human” qualities. In order to make the case for the humorous in migration research, the article illustrates how refugees arriving to the Greek island of Lesvos in the early summer of 2015 laughed at their own predicament as well as the technologies put in place to control their freedom of movement and how their laughter, humor and comic displays did important political work in refusing subjugation, in speaking truth to power and in capturing the absurdity of the violence that they faced.
A Ciência no Estado de Rondônia: Estudo Cientométrico Baseado em Grupos de Pesquisa
Authors: Maroldi Alexandre Masson , Lima Luis Fernando Maia , Hayashi Carlos Roberto Massao , Hayashi Maria Cristina Piumbato Innocentini
Published: June 2022

Visando a preencher uma lacuna nos estudos sobre a ciência em Rondônia este artigo teve como objetivo compreender o estágio atual de desenvolvimento científico, tecnológico e de inovação do Estado e identificar a configuração dos grupos de pesquisas e da produção científica dos pesquisadores que aí atuam. De cunho exploratório e descritivo, a pesquisa adotou a perspectiva metodológica da Cientometria, tendo como fontes de dados o Diretório dos Grupos de Pesquisa no Brasil e a Plataforma de Currículos Lattes do CNPq. As seguintes variáveis dos grupos de pesquisa (n=258) foram analisadas: a) perfil dos membros do grupo, vinculação institucional, área de conhecimento, titulação e gênero dos líderes e pesquisadores, linhas de pesquisa, grupos atípicos, equipamentos e parcerias realizadas; b) indicadores de produção científica, tecnológica e de inovação, tais como a tipologia das publicações (artigos, capítulos, livros, trabalhos em anais de eventos) e dos produtos tecnológicos e de inovação (projetos de pesquisa e extensão, programas de computadores e patentes). Entre os principais resultados destaca-se que o crescimento dos grupos de pesquisa de Rondônia ocorreu somente a partir de 2012; que os anais de eventos científicos são o canal de publicação preferencial dos líderes e que há assimetrias de gênero relacionadas à titulação e à produção científica e tecnológica dos líderes. O diagnóstico realizado comprova a contribuição científica dos grupos de pesquisa para a ciência de Rondônia, haja vista os índices alcançados na análise do perfil de seus integrantes e na produção científica, tecnológica e de inovação dos líderes.
Redes do Empreendedorismo: Perspectivas e Desafios para a Produção Acadêmica
Authors: Oliveira Xênia L'amour Campos , Davel Eduardo Paes Barreto
Published: June 2022

A pesquisa sobre redes e empreendedorismo (ReE) é ampla e aborda temas diversos. O objetivo deste artigo é construir um panorama integrado e crítico da produção acadêmica sobre redes e empreendedorismo, desenvolvendo e discutindo novas perspectivas para renovar a pesquisa futura. Para isso, foi realizada uma revisão sistemática de produções acadêmicas sobre o tema, compostas por artigos científicos, capítulos de livros e livros, que foram publicadas em bases de dados nacionais e internacionais. Os resultados da pesquisa proporcionam um conhecimento atualizado e integrado sobre a temática (relevâncias, concepções, campos empíricos e metodologias) e sobre novos desafios, concepções e contextos para pesquisas futuras. Diante desta análise, propomos e discutimos quatro implicações e perspectivas para a pesquisa sobre ReE: (a) renovação da base teórico-conceitual das pesquisas a partir da adoção de novas perspectivas advindas do campo de redes; (b) renovação do campo empírico com enfoque no contexto da Economia Criativa; (c) necessidade de sofisticação das metodologias de orientação qualitativa para melhorar o refinamento e a complexidade teórica das pesquisas; e (d) impacto na formação e prática empreendedora.
ÜSKÜDAR VE KAYSERİ’DE İŞLENEN GAYR-I AHLAKİ SUÇLAR
Authors: YÜCETÜRK Seher
Published: June 2022

Üsküdar ve Kayseri 17. yüzyılın İlk Çeyreğinde farklı konumları, ekonomik ve kültürel yapıları ile yekdiğerinden farklı iki yerleşim yeri idi. Söz konusu zaman dilimi içerisinde Üsküdar payitahta komşu olması dolayısı ile merkezi konumda bulunmakta idi. Ayrıca Celali İsyanları sırasında İstanbul’a giriş kapısı görevi gören işlek bir merkezdi. Bu durum Üsküdar’ın ekonomik ve kültürel anlamda hareketli bir yer olmasını sağlamıştır. Özellikle nüfus yönünden zenginleşen Üsküdar’da kurulan bekâr odalarının suçlara tesiri ve düzenlemiş oldukları işret meclislerinin varlığı Üsküdar’ı gayr-ı ahlaki davalar yönünden olumsuz manada zenginleştirmiştir denilebilir. Buna karşın Kayseri Selçuklular zamanında başkent olmuş bir yerleşim yeri idi. 17.yüzyılın ilk çeyreğinde ise merkezden uzak muhafazakâr yapısı ile dikkat çeken, doğu-batı kuzey-güney yönlerindeki ulaşım yolarının kesiştiği, kültürel ve ticari anlamdaki hareketlilik ile ön plana çıkmaktadır. Aynı zaman dilimi içerisinde farklı özellikleri ile dikkati çeken bu iki yerleşim yeri artıları ve eksileri ile suçların işlenme oranları ve davaların mahkemeye yansımasında etkin rol oynamışlardır. Özellikle zina, fuhuş ve tecavüz gibi davalarda Kayseri mahkemesine yansıyan davalar Üsküdar’a oranla sınırlıdır. Özellikle kırsal kesimde ve muhafazakâr yapının etkili olduğu yerlerde gayrı ahlaki davaların çeşitli etkenlerin varlığı sebebiyle –kültürel baskı, mahkemeye ulaşmadaki maddi manevi güçlük, ekonomik yetersizlikler- davaların kadınlar tarafından mahkemeye daha az taşınabildiğini düşündürmektedir. Mahkemeye ulaşımın daha zor olduğu yerlerde mahalle ileri gelenlerinin oluşturdukları ve Leslie Peirce’nin de bahsettiği “mahkeme öncesi mahkeme” gibi görev yapıp arabuluculuk sayesinde çözülmüş ve mahkemeye intikal etmemiş çok fazla dava olduğu bilinmektedir. Böylece çözüme kavuşturulan davaların mahkemeye ulaşmamış olma ihtimali, mahkemeye yansıyan kayıtlarda oluşan azlığın bir diğer sebebi olabilir. Her iki yerleşim yeri için farklı birçok etken karşılaştırmaya tabi tutulduğunda ortak olan noktanın varlığı da göze çarpmaktadır. Mahalle kültürü ve bu kültürün suçlar üzerindeki denetiminin her iki yerleşim yerinde de geçerli olduğu görülmüştür. Yapılan çalışmada her iki yerleşim yerinde işlenen suçlar ve bu suçların meydana gelmesindeki itekleyici ve engelleyici durumların tespitine çalışılacaktır. Böylelikle Üsküdar ve Kayseri mahkemelerine yansıyan davalar üzerinden toplumun nabzı tutulmaya çalışılacaktır.
18 - 19. YÜZYILA AİT BİR ATASÖZLERİ MECMUASI: RİSÂLE-İ ḌURÛB-I EMS̠ÂL
Authors: BALYEMEZ Sedat , KARAOĞLU Elif Gizem
Published: June 2022

Atasözleri, duygu ve düşünceleri etkili şekilde aktarmaya yarayan kalıp sözlerdir. Yerinde kullanılmış bir atasözü, anlatımı güçlü ve inandırıcı kılmaktadır. Türkçenin ilk metinlerinden itibaren atasözlerinin varlığı bilinmektedir. Atasözlerinin mecmualarda bir araya getirilmesinin tarihi ise Eski Anadolu Türkçesi dönemine dek uzanmaktadır. Atasözleri mecmualarının özellikle 16. yüzyıldan itibaren arttığı görülmektedir. Türk atasözlerini içeren çok sayıda mecmuanın transkripsiyonlu metinleri; makale, kitap veya bildiri olarak yayımlanmıştır. Bunun yanında henüz transkribe edilmeyen atasözü mecmuaları da vardır. Almanya Milli Kütüphanesinde “Ms.or.quart 1502” numarası ile kayıtlı olan bir yazmanın 66b-93a sayfaları arasında bulunan atasözleri mecmuası da bugüne kadar transkribe edilmeyen mecmualardan biridir. Bu makalede, ilgili mecmuadaki atasözleri transkribe edilecek ve metinle ilgili önemli görülen bazı açıklamalar verilecektir. Böylece Türk atasözleri külliyatına yeni bir metin kazandırılacaktır.
BİLGE KARASU’NUN GECE VE KILAVUZ ADLI ROMANLARINDA POSTMODERN ÖZNE VE ANLATI
Authors: SOYLU Hüseyin
Published: June 2022

Postmodernizm, klasik ve modern düşünme biçimlerinin bütüncül ve sistematik yapısına, normatif kalıplarına karşı ortaya çıkan modernite sonrası bir fenomendir. Hem kültürel hem de düşünsel anlamda geleneksel ayrımlara, kendi içerisinde hiyerarşi oluşturan kavramsal ön kabul ve yargılara karşıdır. İndirgeyici ve tek-merkezli sınıfsal kümelenmeleri ayrıştırır; bunun yerine çok sesli, marjinal bir toplum imgesi yaratır. Edebî anlamda postmodernizm kendi içine kapanmış, çağrışımdan yoksun nihai anlam dizilerini, kurgusal kalıpları kırmaya çalışır. Yazarın tanrı benzeri kurgusal hâkimiyetini, anlatı öznelerinin iki boyutlu yapısını, kalıplaşmış anlatı statükosunu yok eder. Konvansiyonel ikililikleri; kurmaca ile hakikati, sıra dışı ile sıradanı, sahte ile gerçeği, esas ile marjini birbirleriyle çarpıştırır. Batı edebiyatında postmodernist anlatı, modernizme karşı geliştirilen belirli estetik yeniliklerin ve süreçlerin sonucunda ortaya çıkar. Fakat Türk edebiyatında roman sanatı türsel olgunluğuna daha geç dönemde ulaşır. Bu nedenle modernist ve postmodernist estetik nitelikler, kimi eserlerde bir arada bulunur. Postmodernist roman, kendi özgün ve radikal formuna Türk edebiyatında seksenli ve doksanlı yıllarda ulaşır. Bilge Karasu, bu bağlamda postmodernist biçime ve bu biçiminin dinamik özelliklerine eserlerinde yer veren önemli isimlerdendir. Onun Gece ve Kılavuz adlı romanları, postmodern anlatı yapısını ve özne kurgularını içerisinde taşıyan özgün eserlerdendir. Bu çalışmanın amacını, Gece’de ve Kılavuz’da yer alan özne kurgularının, postmodern edebiyatın nitelikleri dikkate alınarak incelenmesi oluşturmaktadır.
TÜRK SANATINDA “TANRI” VE “CENNET” DAMGALARININ BERABER KULLANIMI ÜZERİNE
Authors: ASLAN Yunus , DURAN Remzi
Published: June 2022

İnanış noktasında, Tanrı ve Cennet gibi kavramlardan her biri genellikle semavi dinlere inanan kişilerin karşılaştığı öncelikli kutsal kavramlardandır. Bu iki kavramın sanata yansımaları, soyut birer kavram oldukları için, semboller yoluyla olmak durumundadır. Türk sanatında yer alan sembolik işaretlerin kullanımı, damga vurma geleneği ile doğrudan bağlantılıdır. Damga, Türk devletlerinin ve halklarının kendi benliklerini yansıttığı simgeler olarak, hemen her türlü malzemede kullanılmıştır. Türk sanatında karşılaşmış olduğumuz Tanrı ve Cennet damgalarının beraber kullanımı, Orta Asya’dan ve İran bölgesinden Anadolu’ya kadar, yoğunlukla mimari gelenek yoluyla taşınmıştır. Çalışmamızda örneklerle izlerini takip ettiğimiz bu kutsal geleneğin taş, alçı, tuğla, kerpiç, çini gibi pek çok malzemede, ince bir işçilikle uygulandığını görmekteyiz.

Birer sanat eseri olarak üretilmiş bu damgaların beraber kullanımı, Cennet ve Tanrı kavramlarının, insan zihnindeki anlamlarının benzerlik göstermesi ile yakından ilgilidir. Bu çalışmada, Türk damgalarından kutsallık ifade eden Tanrı ve Cennet damgalarının beraber kullanımı, anlam noktasında irdelenmiş ve sorgulanmıştır.
KONYA VİLAYETİ MERKEZ HAPİSHANESİ İÇİN HAZIRLANAN HAPİSHANE PROJELERİ
Authors: KOLAY Emre
Published: June 2022

Batılılaşma dönemi Osmanlı mimarlığında önemli bir yapı grubu olarak karşımıza çıkan kamu yapılarının oluşum ve gelişim süreçlerini Tanzimat Fermanı’nın ilanı ve sonrasında idari alanda yaşanan dönüşüm çabaları içinde değerlendirebiliriz. Osmanlı arşivlerinde rastlanan belge ve proje dosyaları ışığında kamu yapıları içinde önemli bir yere sahip olduğu görülen hapishaneler ise dönemin mimarlık ortamının politika ve hukuk ekseninde ne derece bir araya gelebildiğini gösteren önemli verilere sahip yapı grubunu oluşturmaktadır. Bu bağlamda Devlet Arşivleri Başkanlığı Osmanlı Arşivi içinde rastladığımız Konya vilayet merkezinde inşa edilmesi düşünülen hapishane binası için farklı tarihlerde tasarlanmış, birbirinden bağımsız tasarım özellikleri sergileyen üç proje, sanat ve mimarlık tarihi disiplini çerçevesinde incelenmektedir. Ayrıca hapishanelerin konumlarıyla doğrudan bağlantılı olan ve farklı kurumlarda bulunan haritalar da söz konusu hapishanelerin konumunu değerlendirme amacı ile kullanılmaktadır.
Numerical investigations of hydraulic transient and thermodynamic characteristics of water flow impacting air pocket inside pipe based on CLSVOF
Authors: Zhu Jianghui , Duan Xiangyu , Wu Guohong , Li Xiaoqin , Tang Xuelin
Published: June 2022

The hydraulic transient and thermodynamic characteristics of water flows impacting an air pocket at the vertical end of an elbow pipe are investigated. The CLSVOF (coupled level-set and volume of fluid) and URANS (unsteady Reynolds-averaged Navier–Stokes) equations with energy equation are implemented, where the RNG (Re-Normalization Group) k–ε turbulence model is adopted and the pressure–density equation is introduced to allow for the water-phase compressibility. All numerical predictions are consistent with the experimental in the literature. The evolution characteristics and mechanism of the water–air interface are analyzed based on the Froude number and dimensionless water–air mixing degree. For air-pocket Type I and Type II with the water–air mixing degree threshold of 10%, based on the first law of engineering thermodynamics and related process laws and basic theory of statistics, the applicability of the ideal gas model in the thermodynamic process of air pocket, the polytropic index regulation in the evolution process and its association with relevant typical thermodynamic processes are systematically analyzed. The polytropic index of air-pocket Type I fluctuates a little with the averaged median of 1.35 in different transient periods under different initial pressure conditions, while it fluctuates largely with the averaged median of 1.26 and 1.21 under the low and the high initial pressure conditions, respectively.