bluuebunny/crossref_metadata_2025 huggingface dataset:
Tunable aziridinium ylide reactivity: non-covalent interactions enable divergent product outcomes
Authors: Nicastri Kate , Zappia Soren , Pratt Jared , Duncan Julia , Guzei Ilia , Fernandez Isra , Schomaker Jennifer
Published: November 2021

Methods for rapid preparation of densely functionalized and stereochemically complex N-heterocyclic scaffolds are in demand for exploring potential new bioactive chemical space. This work describes experimental and computational studies to better understand the features of aziridinium ylides as intermediates for the synthesis of highly substituted dehydromorpholines. The development of this chemistry has enabled the extension of aziridinium ylide chemistry to the concomitant formation of both a C–N and a C–O bond in a manner that preserves the stereochemical information embedded in the substrate. The chemistry is tolerant of a wide range of functionalities that can be employed for DNA-encoded library (DEL) synthesis to prepare diverse libraries of heterocycles with potential bioactivity. In addition, we have uncovered several key insights that describe the importance of steric effects, rotational barriers around the C–N bond of the aziridinium ylide, and non-covalent interactions (NCIs) on the ultimate reaction outcome. These critical insights will assist in the further development of this chemistry to generate novel and complex N-heterocycles that will further expand complex amine chemical space.
Development of a Practical Synthesis of the 8-FDC Fragment of OPC-167832
Authors: Gopalsamuthiram Vijayagopal , Ho Dang , Peck Cheryl , Natarajan Vasudevan , Agrawal Toolika , Burns Justina , Blachert John , Cook Daniel , Stringham Rodger , Nelson Ryan , Ahmad Saeed , Gupton Frank , Snead David , McQuade Tyler , Vaidyanathan Rajappa , Donsbach Kai , Sieber Joshua
Published: November 2021

A concise and practical synthesis has been developed to provide the 8-fluoro-5-hydroxy-3,4-diydrocarbostyril (8-FDC) fragment of OPC-167832 in 41 % yield and in > 99 % purity over 4 steps from 3-amino-4-fluorophenol. The key feature of this process is the development of a telescoped one pot synthesis of the quinolone via a chemoselective amidation and easier product isolation without the need for a column chromatography.
Au(I) Catalyzed HF Transfer: Tandem Alkyne Hydrofluorination and Perfluoroarene Functionalisation
Authors: Mulryan Daniel , Rodwell Jack , Phillips Nicholas , Crimmin Mark
Published: November 2021

HF transfer reactions between organic substrates are an incredibly rare class of transformation. Such reactions require the development of new catalytic systems that can promote both defluorination and fluorination steps in a single reaction sequence. Herein, we report a novel catalytic protocol in which an equivalent of HF is generated from a perfluoroarene | nucleophile pair and transferred directly to an alkyne. The reaction is catalysed by [Au(IPr)NiPr2] (IPr = N,N’-1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene) and is 100 % atom efficient. HF transfer generates two useful products in the form of functionalised fluoroarenes and fluoroalkenes. Mechanistic studies (rate laws, KIEs, DFT calculations, competition experiments) are consistent with the Au(I) catalyst facilitating a catalytic network involving both concerted SNAr and hydrofluorination steps. The nature of the nucleophile impacts the turnover-limiting step. The cSNAr step is turnover-limiting for phenol-based nucleophiles while proteodeauration likely becomes turnover-limiting for aniline-based nucleophiles. The new approach removes the need for direct handling of HF reagents in hydrofluorination and offers new possibilities to manipulate the fluorine content of organic molecules through catalysis.
Electrochemically Driven C-N Bond Formation from CO2 and Ammonia at the Triple-Phase Boundary
Authors: Li Junnan , Kornienko Nikolay
Published: November 2021

Electrosynthetic techniques are gaining prominence across the fields of chemistry, engineering and energy science. However, most works within the direction of synthetic heterogeneous electrocatalysis focus on water electrolysis and CO2 reduction. In this work, we moved to expand the scope of this technology by developing a synthetic scheme which couples CO2 and NH3 at a gas-liquid-solid triple-phase boundary to produce species with C-N bonds. Specifically, by bringing in CO2 from the gas phase and NH3 from the liquid phase together over solid copper catalysts, we have succeeded in forming formamide and acetamide products for the first time. In a subsequent complementary step, we have combined electrochemical analysis and a newly developed operando spectroelectrochemical method, capable of probing the aforementioned triple phase boundary, to extract an initial level of mechanistic analysis regarding the reaction pathways of these reactions and the current system’s limitations. We believe that the development and understanding of this set of reaction pathways will play an exceptionally significant role in expanding the community’s understanding of on-surface electrosynthetic reactions as well as push this set of inherently sustainable technologies towards widespread applicability.
Intelligent Molecular Identification for High Performance Organosulfide Capture Using Active Machine Learning Algorithm
Authors: Chen Yuxiang , Liu Chuanlei , An Yang , Lou Yue , Zhao Yang , Qian Cheng , Jiang Hao , Wu Kongguo , Zhang Xianghui , Sun Hui , Wu Di , Shen Benxian , Cao Fahai
Published: November 2021

Machine learning and computer-aided approaches significantly accelerate molecular design and discovery in scientific and industrial fields increasingly relying on data science for efficiency. The typical method used is supervised learning which needs huge datasets. Semi-supervised machine learning approaches are effective to train unlabeled data with improved modeling performance, whereas they are limited by the accumulation of prediction errors. Here, to screen solvents for removal of methyl mercaptan, a type of organosulfur impurities in natural gas, we constructed a computational framework by integrating molecular similarity search and active learning methods, namely, molecular active selection machine learning (MASML). This new model framework identifies the optimal molecules set by molecular similarity search and iterative addition to the training dataset. Among all 126,068 compounds in the initial dataset, 3 molecules were identified to be promising for methyl mercaptan (MeSH) capture, including benzylamine (BZA), p-methoxybenzylamine (PZM), and N,N-diethyltrimethylenediamine (DEAPA). Further experiments confirmed the effectiveness of our modeling framework in efficient molecular design and identification for capturing methyl mercaptan, in which DEAPA presents a Henry's law constant 89.4% lower than that of methyl diethanolamine (MDEA).
A Highly Fluorescent Dinuclear Aluminium Complex with Near-Unity Quantum Yield
Authors: Portwich Flavio Luis , Carstensen Yves , Dasgupta Anindita , Kupfer Stephan , Wyrwa Ralf , Görls Helmar , Eggeling Christian , Dietzek Benjamin , Gräfe Stephanie , Wächtler Maria , Kretschmer Robert
Published: November 2021

The high natural abundance of aluminium makes the respective fluorophores attractive for various optical applications, but photoluminescence quantum yields above 0.7 have yet not been reported for solutions of aluminium complexes. In this contribution, a dinuclear aluminium(III) complex featuring enhanced photoluminescence properties is described. Its facile one-pot synthesis originates from a readily available precursor and trimethyl aluminium. In solution, the complex exhibits an unprecedented photoluminescence quantum yield near unity (Φabsolute 1.0 ± 0.1) and an excited-state lifetime of 2.3 ns. In the solid state, J-aggregation and aggregation-caused quenching are noticed, but still quantum yields of 0.6 are observed. Embedding the complex in electrospun nonwoven fabrics yields a highly fluorescent fleece possessing a quantum yield of 0.9 ± 0.04.
Active mechanical threading by a molecular motor
Authors: Bach Nicolai N. , Josef Verena , Maid Harald , Dube Henry
Published: November 2021

Molecular motors transform external energy input into directional motions and offer exquisite precision for nano-scale manipulations. In order to make full use of molecular motor capacities, their directional motions need to be transmitted and used for powering downstream molecular events – a current great challenge for molecular engineers. Here we present a macrocyclic molecular motor structure able to perform repetitive molecular threading of a flexible polyethylene glycol chain through the macrocycle. This mechanical threading event is actively powered by the motor motions and leads to a direct translation of the unidirectional motor rotation into an unidirectional translation motion (chain versus ring). The step by step mechanism of the active mechanical threading is elucidated and also the actual threading step is identified as a combined helix inversion and threading event. The here established molecular machine function resembles the crucial step of macroscopic weaving or sewing processes and therefore offers a first entry point for realizing a “molecular knitting” counterpart.
Molecular Communications in Complex Systems of Dynamic Supramolecular Polymers
Authors: Crippa Martina , Perego Claudio , de Marco Anna , Pavan Giovanni M.
Published: November 2021

Supramolecular polymers are composed of monomers that self-assemble non-covalently, generating distributions of monodimensional fibres in continuous communication with each other and with the surrounding solution. Fibres, exchanging molecular species, and external environment constitute a sole complex system, which intrinsic dynamics is hard to elucidate. Here we report coarse-grained molecular simulations that allow studying supramolecular polymers at the thermodynamic equilibrium, explicitly showing the complex nature of these systems, which are composed of exquisitely dynamic molecular entities. Detailed studies of molecular exchange provide insights into key factors controlling how assemblies communicate with each other, defining the equilibrium dynamics of the system. Using minimalistic and finer chemically relevant molecular models, we observe that a rich concerted complexity is intrinsic in such self-assembling systems. This offers a new dynamic and probabilistic (rather than structural) picture of supramolecular polymer systems, where the travelling molecular species continuously shape the assemblies that statistically emerge at the equilibrium.
Synthesis and nanoscale characterization of hierarchically assembled molecular nanosheets
Authors: Richard-Lacroix Marie , Küllmer Maria , Gaus Anna Laurine , Neumann Christof , Tontsch Christian , von Delius Max , Deckert Volker , Turchanin Andrey
Published: November 2021

Chemical functionalization of molecular two-dimensional (2D) materials towards the assembly of hierarchical functional nanostructures is of great importance for nanotechnology including areas like artificial photocatalytic systems, nanobiosensors or ultrafiltration. To achieve the desired functionality of 2D materials, these need to be characterized down to the nanoscale. However, obtaining the respective chemical information is challenging and generally requires the application of complementary experimental techniques. Here, we demonstrate the synthesis and chemical characterization of hierarchically assembled molecular nanosheets based on about 1 nm thin, molecular carbon nanomembrane (CNM) and covalently grafted, single-molecule layer cobalt(III) catalysts for the light-driven hydrogen evolution reaction (HER). We employ X-ray photoelectron spectroscopy (XPS) and tip-enhanced Raman spectroscopy (TERS) to access both the transversal and lateral chemical information of the synthesized nanosheets with nanometer resolution. TERS and XPS data provide detailed information on the average and local surface distribution of the catalyst as well as mechanistic details of the grafting reaction. The proposed approach represents a general route towards a nanoscale structural analysis for a variety of molecular 2D materials - a rapidly growing materials class with broad prospects for fundamental science and applications.
Risk factors and features of COVID-19 course in pregnant women: a comparative analysis of epidemic outbreaks in 2020 and 2021
Authors: Belokrinitskaya Tatiana E. , Frolova Nataly I. , Kolmakova Kristina A. , Shametova Evgeniya A.
Published: November 2021

Aim. To compare risk factors, features of COVID-19 course and outcomes in pregnant women during epidemic increase in incidence in 2020 and 2021.
Materials and methods. The study included 163 pregnant women with laboratory-confirmed SARS-CoV-2 infection within May December 2020 (1st2nd waves of the epidemic) and 158 pregnant women who had new coronavirus infection within May August 2021 (3rd wave of the epidemic). Patients in all groups were comparable in age (1835 years), social status, parity, body mass index, and had no known risk factors for COVID-19.
Results. Iron deficiency anemia, smoking, belonging to the Buryat ethnic group were recognized as persistent risk factors for COVID-19 in pregnant women. Over the 1st year of the pandemic, in pregnant women, the following clinical manifestations of novel coronavirus infection were commonly seen: anosmia (87.7%), somnolence (68.7%), shortness of breath even with a mild lung damage (68.1%). In the 3rd wave of the 2nd year of the pandemic, the leading signs and symptoms were cough (70.3% vs 38.7%, p0.001), runny nose (46.2% vs 3.7%, p0001), sore throat (367% vs 37%, p0.001); an increase in body temperature above 38C (19.6% vs 7,4%, p=0.006), pneumonia detected by computed tomography (61.4% vs 21.4%; p0.001). There was a significant increase in the incidence of severe lung lesions (with computed tomography 34: 17.7% vs 4.9%; p0.001) and admissions to intensive care units (11.4% vs 6.4%; p= 0041). There was a need for invasive mechanical ventilation (1.89% vs 0%; p=0.118). There was 1 death (0.63% vs 0%; p= 0.492), which was associated with the fulminant course of COVID-19.
Conclusion. Persistent COVID-19 confounders in pregnant women who have no known risk factors in the third trimester of gestation are iron deficiency anemia, smoking, and belonging to the Buryat ethnic group. The clinical course of SARS-CoV-2 infection has changed and became more unfavorable: symptoms of acute respiratory disease (cough, runny nose, sore throat) began to prevail, the rate and severity of pneumonia and rate of mortality increased.
Endometriosis. Case report
Authors: Chechulina Olga V. , Danilova Olga V.
Published: November 2021

Extragenital endometriosis (EGE) is the rarest variant of endometrioid disease. This is a process in which a benign growth of tissue similar to the endometrium in morphological and functional properties occurs outside the uterine cavity. The manifestation of the disease has an erased course characteristic of other diseases and patients are more likely to end up in non-core departments, which is accompanied by errors in treatment tactics. According to the data of T.V. Dresvyanskaya et al., the frequency of EGE is 68% of the number of all cases of detection of endometrioid disease. The article presents a case of successful surgical treatment of EGE of rare localization.
PENGARUH INTELLECTUAL CAPITAL TERHADAP KINERJA KEUANGAN BADAN LAYANAN UMUM (BLU) UIN SYARIF HIDAYATULLAH JAKARTA
Authors: Cahyadi Ady , Yulianti Nur Wachidah , Khotimah Husnul , Setiadi Yudi
Published: November 2021

This research purpose investigates the influence of intellectual capital, as measured by VAICTM that consist of three components of firmsâ€™ resources (human capital, structural capital, and capital employed) to financial performance of Syarif Hidayatullah State Islamic University of Jakarta. This research used SEM PLS as tool for test and data analyze. Result of this research showed that of the seven items were tested in the proxy as financial performance, only three of them that can be processed. They were Fixed Asset Turnover, Return On Assets and Return On Equity. Result of hypothesis testing showed intellectual capital (VAICTM) significantly influence to financial performance of Syarif Hidayatullah State Islamic University of Jakarta.
Analisis Kesiapan Penerapan Badan Layanan Umum Daerah (BLUD) di Puskesmas: Pengujian Luderâ€™s Contingency Model (Studi Deskriptif pada Puskesmas Kabupaten Tanah Datar)
Authors: Misra Fauzan , Sabila Gina Alviyori
Published: November 2021

The purpose of this study was to determine the readiness of the Puskesmas in the implementation of the Regional Public Service Entity (BLUD) in Tanah Datar Regency using Luder's Contingency Innovation Model. The Implementation of BLUD can consider as a form of innovation in the public sector. The study was conducted using a descriptive approach involving 17 financial administrators. Data was collected using interviews and questioner. The results of the study indicate that the application of the BLUD policy at the Tanah Datar District Health Center has been classified as good. By using Luderâ€™s Model to analyze the readiness of Puskesmas to be a fully-BLUD, this study explains the stimuli, stakeholders' role and interest, and obstacles for such innovation implementation in the planning, budgeting, and reporting stage. These findings imply that Tanah Datar District Health Center should be supported by local government in terms of staff competency, training facilities, legal standing, and clarity of the scope of the work.
PENGARUH PROFESIONALISME, ACCOUNTABILITY DAN FEE AUDIT TERHADAP AUDIT QUALITY (STUDI EMPIRIS PADA KAP DI WILAYAH MEDAN)
Authors: Mestika Devy , Simanjuntak Immanuel , Sitepu Wilsa Road Betterment
Published: November 2021

(STUDI EMPIRIS PADA KAP DI WILAYAH MEDAN)Â
FAMILY CONTROL, BIAYA KEAGENAN DAN RISIKO KEUANGAN TERHADAP NILAI PERUSAHAAN
Authors: Mary Hilda
Published: November 2021

The effect of family control, agency cost and financial risk on firm value in company listed on the IDX. Three independent variable this research is family control, agency cost and financial risk and dependendt variabel is company value, and control variable is propability. The sample of this research consisted 100 companies, and technique using rendom sampling method. The result this research indicate that family control has a negative and significant effect on firm value. Agency cost and financial risk do not effect the firm value. And probability has a positive and significant effect on firm value
ANALISIS FAKTOR-FAKTOR YANG MEMENGARUHI INTELLECTUAL CAPITAL DISCLOSURE PADA PERUSAHAAN JASA YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE TAHUN 2017-2019
Authors: Bohalima Eunike Rosni , Zai Alsemeta Natafati , Sitepu Wilsa Road Betterment
Published: November 2021

The main objective of this research is to explore further the various factors that can influence the disclosure of intellectual capital. This test uses independent variables auditor reputation, leverage, independent commissioner, and profitability. Service companies listedÂ on the IDX in the 2017-2019 period were used as the population in this test with a total population of 432 companies. The samples were determined by the purposive sampling method which resulted in a final total of 120 samples from 40 companies. Tests were carried out through multiple linear regression analysis techniques and using SPSS version 25 for windows as a data processing medium.Â Judging from the partial test, the results of this test show that only the leverage and profitability factors affect intellectual capital disclosure, while the independent commissioner and auditor's reputation variables do not affect intellectual capital disclosure. Judging from the simultaneous test, this test shows that the independent variables of auditor reputation, leverage, independent commissioner, and profitability have a simultaneous effect on the dependent variable of intellectual capital disclosure.
http://jurnal.ustjogja.ac.id/index.php/akuntansidewantara/about/submissions#onlineSubmissions
Authors: Sukanta Sukanta
Published: November 2021

In determining the cost of production and sales of a product unit is often faced with problems in making decisions. Determination of the cost of the production unit can be done more quickly and there is a standardized calculation method correctly and correctly. The purpose of this research is to determine and calculate the cost of production per unit of product in a certain amount based on the imposition of production costs. Imposing production costs. The production cost calculation is determined on these production cost components, both by direct and indirect costing in accordance with the organizational structure approach of the company concerned. The result of the research shows that the calculation of the unit cost for the Inner tube product based on the current experience and knowledge of the company is Rp. 15,200 per unit, while the results of research using the distribution method of the production unit cost of Rp. 13,045 per unit. Thus, there is a difference in the unit cost of the product that is 20% cheaper than it is currently in the company
INVESTIGATING THE PERIODIC STRUCTURE OF TRAFFIC ACCIDENTS IN TURKEY
Authors: AKDİ Yılmaz , KARAMANOĞLU Yunus Emre , ÜNLÜ Kamil Demirberk , BAŞ Cem
Published: November 2021

In this study, a time-series analysis is applied to the daily accidents between the periods January 1, 2019 and December 31, 2019 of Turkey. The most important feature of the data used in the study is the official daily traffic accident records kept by the law enforcement units. Regarding these data, the most appropriate time series model is determined and it is examined whether there are periodic components in traffic accidents or not. It is observed that the data is first-order integrated. In this case, the difference of the series from the first order should be taken in terms of statistical conclusion. When the graphs of the series are examined, the stationarity of the series has been also tested with the periodogram-based unit root test proposed by Akdi and Dickey (1998) with the assumption that possible periodicity can be found in the series, and it has been observed that the series is stationary at the 10% significance level. According to the results 33, 36.5 and 73-day periods are significant in the number of daily traffic accidents in 2019. It has been demonstrated that the 73-day period corresponds to the period between Ramadan Feast and Feast of Sacrifice (there is a 70-day interval between the two religious holidays).
ÖLDÜRME SUÇUNUN SOSYOLOJİK SEBEPLERİ
Authors: OCAKLI Leyla
Published: November 2021

Görsel ve yazılı basında sıkça cinayet haberleriyle karşılaşmaktayız. Cinayete yol açan durumlar çeşitlilik göstermekle beraber; cinnet getirme, töre saikiyle öldürme, ekonomik sorunlar, kıskançlık, uyuşturucu kullanımı, namus cinayeti, sokak kavgası, hakaret gibi sebeplerin cinayete yol açan durumların başında geldiğini söylemek mümkündür. Motivasyonu her ne olursa olsun, her öldürme olayının mutlaka biyolojik, psikolojik ya da sosyolojik bir nedeni vardır ve bu çalışmada öldürme suçunun sosyolojik sebeplerini açıklanmaya çalışmak amaçlanmıştır. Bu kapsamda suç kavramı ve suç teorilerine değinilerek suçlu davranışın genel nedenleri üzerinde durulmuştur. Şuçu açıklayan teorilerin ardından öldürme suçunun Dünya’da ve Türkiye’deki durumu incelenmiş, özellikle gelir durumu ve kültürel yapının cinayet işleme üzerinde etkili olduğu görülmüştür. Dünya geneline bakıldığında, ülkelerin ekonomik yeterlilik ve kültürel yapısına göre intihara yatkınlık ve cinayete yönelim durumlarının farklılık gösterdiği görülmektedir. Böylece, toplumsal yapının öldürme suçu trendleri üzerinde etkili olduğu söylenebilir. Bu noktada, cinayet olaylarının sosyolojik sebepleri oldukça çeşitlilik göstermekte, gelir eşitsizliğinden toplumun eğitim yapısı ve eğitim düzeyine kadar pek çok parametreyi kapsamaktadır. Bu sebeple bir bölgede meydana gelen öldürme olaylarının sebeplerini anlama ve bununla mücadele etmek için öncelikle o bölgedeki toplumsal yapının özellikleri iyi analiz edilmelidir. Zira öldürme suçu evrensel bir suç olsa da sebepleri bölgeden bölgeye farklılık gösterebilir ve bu suçları önlemek için toplumun kültürel yapısının göz önünde bulundurularak önlem alınması gerekmektedir.
ÖZEL GÜVENLİK MESLEK İMAJI VE ÜNİFORMANIN ETKİSİ
Authors: DEMİRCİ Uğur
Published: November 2021

Bireyler, örgütler ve meslekler açısından iş elbisesinden daha fazla anlamlar taşıyan üniformalar meslek imajı üzerinde önemli etkilere sahiptir. Türkiye’de İçişleri Bakanlığı özel güvenlik görevlilerinin saygınlıklarını ve güvenilirliklerini artırmak, olumlu özel güvenlik meslek imajı geliştirmek amacıyla kamu kurumları için tek tip üniforma zorunluluğu başlatmıştır. Araştırma, kamu kurumlarında çalışan özel güvenlik görevlileri ve diğer çalışanların özel güvenlik meslek imajına ve üniformanın bu meslek imajına etkisine ilişkin algılarını tespit etmek amacıyla gerçekleştirilmiştir. Nitel paradigma çerçevesinde gerçekleştirilen araştırma durum çalışması olarak belirlenmiştir. Araştırma, Ankara ilinde bulunan dört kamu kurumunda çalışan özel güvenlik görevlileri ve kurum çalışanlarının katılımıyla gerçekleştirilmiştir. Araştırma kapsamında 47 özel güvenlik görevlisi ve 56 kurum çalışanıyla yüz yüze görüşme gerçekleştirilmiştir. Yapılan analiz neticesinde çok daha fazla kurum çalışanının özel güvenlik meslek imajını özel güvenlik görevlilerine göre olumlu olarak nitelendirdiği tespit edilmiştir. Ayrıca hem özel güvenlik görevlileri hem de diğer çalışanlar açısından yeni üniformanın mesleki imajı olumlu yönde etkilediği tespit edilmiştir.
O Que se Discute sobre Leitura e Ensino de Ciências na Educação Básica: uma Análise das Pesquisas Apresentadas no ENPEC
Authors: Souza Caroline Batista Silva de , Souza Luciana Sedano de
Published: November 2021

Estudos que abordam a relação entre leitura e ensino de Ciências podem ser encontrados desde a década de 1980, sendo inegável o papel importante que a leitura possui em todas as áreas do conhecimento. Diante disso, esta pesquisa investigou como o trabalho com a leitura e o ensino de Ciências na Educação Básica se apresenta nas publicações das edições do Encontro Nacional de Pesquisa em Educação em Ciências (ENPEC), objetivando compreender a relação apresentada entre o trabalho com a leitura e o ensino de Ciências. Para isso, realizamos uma pesquisa qualitativa e do tipo bibliográfica nas atas das edições do ENPEC de 1997 a 2019, buscando por trabalhos que tratavam da temática “leitura e ensino de Ciências”. Entre os trabalhos encontrados, 63 discutiam essa temática, sendo 28 deles referentes à Educação Básica. A pesquisa possibilitou construir um panorama das investigações realizadas e divulgadas sobre o trabalho com leitura e ensino de Ciências nesse evento, apontando que a discussão está presente em poucas pesquisas apresentadas. A análise denotou, ainda, que as tendências dos trabalhos encontrados estão direcionadas para diversas vertentes, desde o uso exclusivo do livro didático como único suporte para a atividade de leitura até discussões sobre a inquestionável importância da leitura no processo da Alfabetização e Letramento científico, denunciando a enorme preocupação da segregação entre leitura e ensino de Ciências.
Evaluation of Bone Health among Type 2 Diabetes Mellitus Patients
Authors: Abdulameer Shaymaa , Sahib Mohanad , Syed Sulaiman Syed Azhar
Published: November 2021

Background: Type 2 diabetes mellitus (T2DM) and osteoporosis remain one of the major public health problems worldwide with a considerable burden on society. Health belief toward osteoporosis is fundamental to all osteoporosis management programs and is often a pre-requisite for initiating desired behavioral changes. The aim of this study was to assess: the level of the Malay version of the Osteoporosis Health Belief Scale (OHBS-M) among T2DM patients; the relation of socio-demographic characteristics, clinical data with OHBS-M level and the correlation between OHBS-M score and T-score.
Methods: An observational, cross-sectional study design was conducted among T2DM patients. Socio-demographic and clinical data were collected using a convenient sampling method. All T2DM patients underwent the bone mineral density measurement using a quantitative ultrasound scan (QUS).
Results: The result showed the average age of the participants was 62.67± 9.24 years. The study findings revealed that the average total score of OHBS-M 143.08±24.22 (median 141.50) with 85.60% of T2DM patients had a low level of osteoporosis health belief. Moreover, a significant correlation was found between the QUS T-scores and osteoporosis health beliefs.
Conclusions: The study findings revealed that the assessment of T2DM patients’ bone health and health belief toward osteoporosis is crucial to improve an osteoporosis preventive strategy for high-risk populations.
Pelatihan Preparasi Kromosom Dan Analisis Karyotipe Pada Dosen-Dosen Biologi Di Universitas Nahdlatul Wathan Mataram
Authors: I Gde Mertha  , Agil Al Idrus  , Ahmad Raksun  , I Wayan Merta  , Syamsul Bahri
Published: November 2021

Dalam upaya untuk meningkatkan kompetensi dosen di bidang penelitian diperlukan keterampilan, pengalaman dan kemampuan dasar yang kuat dalam metode dan teknik-teknik penelitian yang senantiasa berkembang dari waktu ke waktu. Dengan demikian perlu bagi seorang dosen untuk selalu mengikuti perkembangan teknik-teknik penelitian baru serta tukar pengalaman diantara sesama terutama pada pakar yang berhubungan dengan keilmuannya. Kegiatan pengabdian ini telah dilaksanakan di Universitas Nahdlatul Wathan Mataram. Tujuan pengabdian ini adalah meningkatkan wasasan dan keterampilan dosen-dosen biologi melalui pendamping praktikum agar dapat membuat preparat squash untuk pengamatan struktur dan morfologi kromosom metafase, penyusunan karyogram, dan analisis karyotipenya. Kegiatan pelatihan ini dilakukan dengan menggunakan beberapa metode, yaitu ceramah, tanya jawab, diskusi, dan unjuk kerja berupa kegiatan praktik, yang selanjutnya dilakukan refleksi dan evaluasi. Kegiatan praktik yang dilakukan, yaitu (a) praktik mikroteknik pembuatan preparat squash kromosom, (b) praktik identifikasi struktur dan morfologi kromosom dibawah mikroskop, (c) praktik pengambilan foto struktur dan morfologi kromosom dibawah mikroskop, (d) praktik penyusunan karyogram kromosom metafase, dan (e) praktek analisis karyotipe kromosom. Berdasarkan hasil evaluasi terhadap kegiatan pengabdian ini dapat disimpulkan sebagai berikut: (1) Pengabdian ini memberikan pengalaman sangat bermanfaat tentang teknik pembuatan preparat untuk pengamatan morfologi kromosom, teknik dokumentasi kromosom dibawah mikroskop dan pengukuran parameter dalam analisis karyotipe, (2) Motivasi yang tinggi dosen mitra sangat menunjang keberhasilan pembuatan preparat kromosom dan analisis karyotipe dalam pelatihan ini, dan (3) Pengetahuan dan keterampilan yang diperoleh dosen mitra merupakan bekal ipteks berbasis kromosom yang sangat berhaga untuk kegiatan perkuliahan dan penelitian.
IDENTIFIKASI JENIS DAN KONDISI POPULASI TUMBUHAN PAKU (Pteridophyta) DI BLOK KOLEKSI TAMAN HUTAN RAYA WAN ABDUL RACHMAN
Authors: Savira Elza Novelia , Indriyanto Indriyanto , Asmarahman Ceng
Published: November 2021

Taman Hutan Raya Wan Abdul Rachman memiliki Blok Koleksi yang salah satunya berfungsi melestarikan jenis-jenis tumbuhan, termasuk jenis-jenis tumbuhan paku (Pteridophyta). Penelitian ini bertujuan untuk mengetahui jenis-jenis tumbuhan paku, kerapatan populasi tiap jenis, serta jenis tumbuhan paku yang dominan. Penelitian dilakukan secara survai dengan metode garis berpetak dengan intensitas sampling sebesar 2%. Luas Blok Koleksi adalah 141,18 ha, luas seluruh plot sampel adalah 28.236  atau sebanyak 70 buah plot. Hasil penelitian teridentifikasi 16 jenis tumbuhan paku yang terdiri atas 3 jenis paku epifit, 4 jenis paku epifit dan terestrial, dan 9 jenis paku terrestrial pada kondisi tegakan hutan yang tersusun oleh 39 jenis tumbuhan dengan kerapatan 1.078,4 individu/ha. Jenis tumbuhan paku yang ditemukan yakni Adiantum pediantum, Asplenium pellucidum, Athyrium japonicum, Cyclosorus parasiticus, Davallia denticulata,Drynaria sparsisora, Thelypteris sp., Stenoclaena polustris, Goniophlebium verrucosum, Leucostegia pallida, Nephrolepis dicksoniades, Pteris grandifolia, Selliguea deckokii, Diplazium simplivicacium, Pteris mulfida, dan Vittaria elongata. Kisaran kerapatan dari tumbuhan paku yakni sebesar 3.333,57 pohon/ha yang diikuti oleh tiga jenis tumbuhan paku yang dominan yakni Davallia denticulate, Stenoclaena polustris, Leucostegia pallida dengan nilai INP sebesar 14,55, 11,42, dan 10,4. Selanjutnya terdapat pula jenis tumbuhan penopang paku epifit yakni Tangkil (Gnetum gnemon), kelapa (Cocos nucifera), randu (Ceiba pentandra), jengkol (Pithecellobium lobatum), nangka (Artocarpus heterophyllus) dengan jenis tumbuhan penopang yang dominan yakni jenis tangkil (Gnetum gnemon)
IDENTIFIKASI PERSEPSI RESPONDEN TERHADAP WISATA ALAM PUSRI, DANAU RANAU OKU SELATAN, PROVINSI SUMATERA SELATAN
Authors: Setiyawan Eko , Winarno Gunardi Djoko , Fitriana Yulia Rahma , Yuwono Slamet Budi
Published: November 2021

Persepsi wisatawan sangat penting dalam pengembangan wisata karena sebagai dasar pengambilan keputusan bagi pihak pengelola wisata. Tujuan dari penelitian ini adalah indentifikasi persepsi responden terhadap aspek fasilitas dan pelayanan, akomodasi, infrastruktur, alam dan lingkungan di Wisata Alam Pusri Danau Ranau. Pengambilan data dilakukan dengan metode observasi langsung dan kuesioner wawancara tertutup. Data yang diperoleh kemudian dianalisis secara deskriptif kualitatif. Hasil penelitian menunjukkan persepsi responden memberikan penilaian yang bervariasi terhadap Wisata Alam Pusri Danau Ranau untuk setiap aspek penilaian diantaranya: aspek alam dan lingkungan sebesar 3,91 (cukup baik), aspek akomodasari sebesar 3,45 (cukup baik), aspek infrastruktur sebesar 3,22 (cukup baik) dan aspek fasilitas dan pelayanan sebesar 3,38 (cukup baik). Unsur yang harus diperhatkan yaitu pada sektor kebersihan lingkungan karena responden masih belum puas terhadap unsur tersebut yang mana dapat dilihat dari hasil nilai rata-rata terhadap kebersihan sebesar 2,91 (tidak baik) sedangkan pengelolaan sampah sebesar 2,71(tidak baik) dan toilet sebesar 2,54 (tidak baik). Kebersihan lingkungan perlu diperhatikan agar wisata tetap indah serta pembenahan fasilitas seperti pengadaan kotak sampah.
Economic model of microtransactions in video games
Authors: Tomić Nenad Zoran
Published: November 2021

Abstract: Microtransactions denote a payment made for purchase of mobile phone application or additional content in video games. The basic revenue principle for publisher was to sell the entire content at once, with the buyer having to pay the game as a whole. Trends from mobile applications and mobile games market have slowly transferred to PC games and console video games. About one half of total revenue of big video games publishers comes from microtransactions. The topics of this paper are the economic effects of microtransactions on video game industry business model. The scope of microtransactions and different implementing procedures will be discused in paper. The goal is to determine the change of the position of all stakeholders involved in the process of creating and publishing video games.
Alcohol and Glucose D consumption decreases grip muscle strengths in graded doses
Authors: Omoirri Moses Aziakpono  , Uyovwiesevwa Ataihire Johnson  , Orji Uchechukwu Harrison  , Chukwuemeka Charles Ofili  , Nwosu Gloria Chizoba  , Mba Ogbonnaya  , Olusola Ayobami John  , Mbata Uchenna Chisom
Published: November 2021

Alcohol, Blood Sugar, and Grip muscle strengths (GMS) may play key role in injury prevention and rehabilitation. In many cases, strengthening of the grip has been a prescription for rehabilitation from injuries such as golf and tennis elbow. In this study, the effects of alcohol and glucose consumption on grip muscle strength in early adult male subject was investigated. A total of thirty (200) human subjects of about18+ years old were recruited for the study. The subjects were administered varying doses of alcohol and glucose D, then allowed to rest for a period of 5 and 10 minutes before assessing their grip muscle strength, fasting blood sugar (FBS) and body weights. Obtained records were then compared with those of control (normal) subject who neither received alcohol nor glucose D. Differences in mean was obtained between groups using the student t-test. From the result, study found a statistically significant decrease (p < 0.05) in GMS for different times (5 min and 10 min) of alcohol administration as compared with control subjects. A notable significant decrease (p > 0.05) was also observed for FBS with increasing administration times as compared with control. This decrease was however insignificant for 10 min duration compared with 5 minutes. This decrease was however significant (p < 0.05) for alcohol 5 min intake as compared with control group. All test group (experimental) showed a statistically significant decrease in GMS after alcohol administration as compared with control. Lastly, a statistically significant decrease (p < 0.05) was observed in GMS for 10 min of Glucose D intake. Whereas, subject who took glucose D in 5 min showed an insignificant decrease as compared with control. It is recommended that more studies be conducted to corroborate the result of this study.
Anti-plasmodial Effect of C. limon and C. paradisi extracts on Plasmodium berghei-infected mice
Authors: Michael Okpara Elom  , Anthony Gideon Uche  , Boniface Nwofoke Ukwah  , Victor Udoh Usanga  , Anthonia Ifeoma Okpara-Elom  , Michael Erem Kalu  , Onyekachi Ewa Ibe
Published: November 2021

Antiplasmodial effect of Citrus limon and Citrus paradisi extracts on Plasmodium berghei-infected mice was studied. Twenty five albino mice were randomized into five categories of G, L, GL, ACT (positive control) and NC which stand for grape, lemon, grape and lemon combined extracts, artemisinin combined therapy and negative control respectively. The NC group did not receive any intervention. Other treatments were administered orally for 12 days whereas administration of ACT lasted for 3 days. Blood was collected from the tail vein of the mice at a three day interval through venipuncture. Thick blood films were prepared and parasite densities were estimated using standard parasitological techniques. Results were analysed with ANOVA and Duncan multiple range tests. There was no significant difference (p>0.05) between parasite densities of the treatment groups and the negative control at baseline levels. However, as the treatment progressed from day 3 through day 9, there were significant reductions (p<0.05) in parasite densities among treatment groups when compared to the negative control. In this study, extracts of C. limon and C. paradisi in both single and combined strengths have been found to have antiplasmodial properties in mice. ACT possessed the highest antiplasmodial effect while C. limon as a single treatment ranked second in possession of antiplasmodial activity but exhibited increased RBC lysis. In combination, C. limoni and C. paradise extracts showed antiplasmodial activity that is slightly less than that exhibited by the lemon extract alone, but maintained normal RBC morphology whereas C. paradisi extract alone exhibited the lowest level of parasite clearance with atrophied red blood cells. Investigation of the effects of the extracts on liver, kidney and gastrointestinal tissues of mice is recommended before they could be prescribed as antimalaria for other animals and humans.
Restoration of the anterior guide with the fixed prosthesis
Authors: Sihem Hajjaji  , Shayma Karray  , Hayet Hajjemi  , Abdelatif Boughzela
Published: November 2021

The anterior guide is a functional entity, which is part of the set of guidance provided by the dento-dental joints to the mandibular kinematics, essential for the establishment of harmonious occlusal relations. The anterior guide is a key to understanding and reconstructing the occlusion, playing both a role of protecting the posterior teeth and guiding the functional movements of the mandible. Currently, it also represents an “exteroceptive feeler” creating a cone of access to the occlusion in intercuspation. The restoration of functional and protective anterior guidance is therefore essential for the balance of the masticatory system. This rehabilitation can only be achieved by examining and accurately diagnosing the occlusion relationships maintained by the anterior teeth, associated with a reasoned therapeutic approach validated by a test phase. After a brief description of the anterior function and its role, this article aims to detail, through a clinical case, the procedure to follow for the restoration of a functional anterior guide.
Pelatihan Teknik Komunikasi Efektif Pada Kader Keluarga Berencana Di Desa Panggungharjo
Authors: Retno Heru Setyorini  , Andina Vita Sutanto
Published: November 2021

Komunikasi adalah kunci terpenting untuk membangun hubungan yang baik antara semua orang. Penyampaian pesan secara lisan atau tulisan mengharapkan seseorang dapat membaca atau mendengar apa yang dikatakan dengan benar. Komunikasi yang efektif sangat tergantung pada keterampilan seseorang dalam mengirim dan menerima pesan. Tujuan pengabdian kepada masyarakat ini adalah meningkatkan kemampuan kader dalam melakukan komunikasi efektif untuk mendukung tugasnya sebagai kader keluarga berencana. Pelaksanaan kegiatan dengan memberikan materi tentang komunikasi efektif kepada 50 kader di Desa Panggungharjo menggunakan metode ceramah, tanya jawab, dan roleplay, dengan menggunakan media LCD Projector dan Power Point. Peserta banyak yang mengajukan pertanyaan terkait dengan teknik komunikasi efektif untuk memecahkan masalah dan kendala yang ditemui di lapangan pada saat memberikan komunikasi, informasi, dan edukasi (KIE), maupun pada saat memberikan motivasi pada pasangan usia subur untuk menggunakan kontrasepsi. Pelatihan komunikasi efektif yang menjelaskan pengertian, tujuan, manfaat komunikasi dan hambatan-hambatan dalam komunikasi mampu meningkatkan kemampuan kader dalam melakukan komunikasi efektif.
Webinar tentang Peningkatan Pengetahuan Remaja Putri Dalam Mengatasi Dismenore di Masa Pandemi COVID-19
Authors: Nining Tunggal Sri Sunarti  , Winarsih
Published: November 2021

Nyeri haid merupakan permasalahan yang sering terjadi pada seorang perempuan Banyak wanita yang mengalami masalah menstruasi, di antaranya adalah nyeri saat menstruasi yang dikenal dengan dismenore. Dismenore mempengaruhi 40% sampai 70% dari wanita usia reproduksi dan merupakan salah satu penyebab yang paling sering untuk absen sekolah. Penelitian di Amerika Serikat, dismenore adalah penyebab paling utama ketidakhadiran berulang disekolah. Beberapa penelitian telah menunjukkan bahwa remaja dengan dismenore mengalami penurunan pada prestasi akademis, sosial dan kegiatan olahraga.Kegiatan pengabdian yang dilaksanakan melalui kegiatan webinar dengan metode ceramah. Pengabdian tentang pemberdayaan remaja putri dalam mengatasi Dismenore di Masa Pandemi COVID-19 dengan peserta 37 remaja mahasiswi Sekolah Tinggi Ilmu Kesehatan AKBIDYO. Kegiatan diadakan pada hari minggu, tanggal 18 Juli 2021 yang disajikan melalui webinar zoom meeting, karena sedang dalam masa Pemberlakukan Pembatasan Kegiatan Masyarakat (PPKM). Kegiatan dapat dilaksanakan dengan lancar. Kesimpulan yang didapat: Pengetahuan remaja peserta webinar mengalami peningkatan 4,17%. Pengetahuan remaja peserta webinar terbanyak dalam kategori baik dengan nilai saat pre 79,16% dan saat post sebesar 83,33%. Saran bagi remaja setelah mendapatkan informasi tentang dismenore dan cara mengatasinya diharapkan terjadi perubahan sikap dan perilaku lebih siap dalam menghadapi dismenore dan bagi Pembicara membuat webinar terjadwal dan terstruktur yang terus berfokus pada remaja dengan melihat riset dan isu terkini.
PESANTREN'S EDUCATION STRATEGY IN IMPROVING SANTRI'S LIFE SKILLS AT DARUS�SAADAH ISLAMIC BOARDING SCHOOL
Authors: Ulya Fatihatu Nurul , Zafi Ashif Az
Published: November 2021

Like in general, Islamic boarding schools only provide education to students with religious knowledge and morals as the main substance but do not provide the students with skills. As a result, the Pondok Pesantren alumni arose in their hearts a feeling of not mastering their skills when they brought them to their hometowns. Given such a situation, providing life skills is expected to be an alternative to this problem. This study provides an overview of what strategies are applied in implementing life skills education at the Darussa'adah Jekulo Kudus Islamic boarding school. This research uses a field case study. The data collection technique was used by pins in the form of observation methods, interviews with informants, and documentation. While the data analysis technique used is descriptive qualitative analysis techniques. This research was conducted at the Darussa'adah Hadipolo Jekulo Kudus Islamic boarding school. The results showed that the strategies used in improving life skills education ran quite effectively and yielded results. These results can be seen from the material presented by the management and caregivers and the high enthusiasm of all students in carrying out gardening and entrepreneurship activities owned by the Islamic Boarding School. The strategies used in developing entrepreneurial skills at the Darussa'adah Islamic Boarding School were quite successful, as evidenced by the development of plantations and entrepreneurship belonging to the Islamic Boarding Schools.Keywords: Education, Life Skill, Islamic Boarding School�
DISCLOSURE DE PASSIVOS CONTINGENTES EM INSTITUIÇÕES BANCÁRIAS LISTADAS NA B3
Authors: Barroso Lorena de Mattos , Taveira Lis Daiana Bessa , Penha Roberto Silva da
Published: November 2021

Este estudo busca verificar quais as características de divulgação dos Passivos Contingentes das Instituições bancárias listadas na B3 entre os anos de 2014 e 2017. Para consecução do objetivo, a metodologia utilizada foi pesquisa descritiva e documental, e abordagem de natureza qualitativa, com análise de relatórios anuais de instituições bancárias no Brasil, avaliando as demonstrações contábeis, com foco nas provisões o nos Passivos Contingentes. Os dados foram coletados nas demonstrações consolidadas no site da B3. Os resultados da pesquisa indicam haver divulgação principalmente de processos já em tramites judiciais, relacionados, a causas cíveis, trabalhistas e fiscais. Houve um alto índice de divulgação de passivos contingentes entre as empresas da amostra, o que denota a uma preocupação com o nível de disclosure das demonstrações financeiras analisadas.
ANÁLISE DA EVOLUÇÃO DAS ATIVIDADES DE INVESTIMENTO NO FLUXO DE CAIXA DE EMPRESAS DO SETOR DE TELECOMUNICAÇÕES
Authors: Oliveira Carlos Eduardo de , Silva Carolina Parreira da , Fernandes Lorraine Alves , Lima Caroline Aparecida , Oliveira Fernando Souza de
Published: November 2021

O objetivo do estudo foi verificar a evolução das atividades de investimento, apresentadas no Fluxo de Caixa, das empresas do setor de telecomunicações, listadas na B3. Esta pesquisa descritiva realizou coleta de dados no site da B3, das Demonstrações dos Fluxos de Caixa no período de 2013 a 2015. Os principais resultados apontam que (1) em relação aos valores das atividades de investimento, pode-se inferir que os maiores investimentos foram realizados pelas empresas Telefônica, Oi e Tim; (2) a Telefônica, Telebrás e Oi foram as que apresentaram as maiores evoluções relativas (%), (3) verificou-se evolução dos investimentos do setor; (4) as empresas aumentaram os gastos em atividades de investimento, isso demonstra o interesse pela evolução dos serviços prestados aos consumidores, bem como uma necessidade de atuar de forma competitiva em um mercado de acirrada concorrência.