bluuebunny/crossref_metadata_2025 huggingface dataset:
Fovea-UNet: Detection and Segmentation of Lymph Node Metastases in Colorectal Cancers with Deep Learning
Authors: Liu Yajiao , Wang Jiang , Wu Chenpeng , Liu Liyun , Zhang Zhiyong , Yu Haitao
Published: April 2023

Objective: Colorectal cancer is one of the most serious malignant tumors, and lymph node metastasis (LNM) from colorectal cancer is a major factor for patient management and prognosis. Accurate image detection of LNM is an important task to help pathologists diagnose cancer. However, effective image detection with the whole slide image (WSI) can only be performed by patch-based classification method, which are far from enough for cancer region segmentation and location due to a small patch image has less non-local contextual information. Recently, the U-Net architecture has been widely used to segment image to accomplish more precise cancer diagnosis. In this work, we aggregate the detailed and non-local contextual information into a U-Net baseline to segment the important region with high diagnostic value.
Method: Inspired by the working principle of Fovea in visual neuroscience, a novel network framework based on U-Net for cancer segmentation named Fovea-UNet is proposed to adaptively adjust the resolution according to the importance-aware of information and selectively focuses on the region most relevant to colorectal LNM. Specifically, we design an effective adaptively optimized pooling operation called Fovea Pooling (FP), which dynamically aggregate the detailed and non-local contextual information according to pixel-level feature importance. In addition, the improved lightweight backbone network based on GhostNet is adopted to reduce the computational cost caused by FP pooling.
Results & Conclusions: Experimental results show that our proposed framework can achieve higher performance than other state-of-the-art segmentation networks with 92.82% sensitivity and 88.51% F1 score on the LNM dataset.
Clinical impact: The proposed framework can provide a valid tool for cancer diagnosis, especially for LNM of colorectal cancer.
Formal analysis of ECC-based RFID authentication protocol in logic of events theory
Authors: Xiao Meihua , Chen Quangang , Li Zehuan , Chen Yuqiong , Xu Ruihan
Published: April 2023

Today, the rapid development of the Internet of Things (IoT) has greatly affected human life, and the security analysis of authentication protocols in IoT is increasingly important. Radio Frequency Identification (RFID) is a crucial component of IoT, and RFID using Elliptic Curve Cryptography (ECC) is a public key cryptosystem authentication approach that tackles the problem of electronic tag data encryption in RFID systems. The formal method is one of the most powerful ways for verifying protocol security, and the Logic of Events Theory (LoET) is a theorem-proving formal logic for analyzing distributed system security. This paper proposes three event classes, Compute, Retrieve, and Generate, and related axioms and inference rules to formally abstract the ECC session key generation function, formally statute the authentication process of both parties, and the extended LoET is used to analyze the security properties of ECC-based RFID security protocols. Under reasonable assumptions, an ECC-based RFID two-way authentication scheme is shown to satisfy the two-way strong authentication feature. It is shown that the extended logic of event theory may be used to prove the security properties of this class of ECC-based RFID protocols.
Tribodiagnostics of engines for special vehicles
Authors: Stodola Jiri , Stodola Petr
Published: April 2023

The paper presents selected information from a research project focused on the diagnosis of engines using a worn lubricant. It introduces sorted information, description and methodology of the project solution and results of practical experiments including the determination of criteria for tribodiagnostic evaluation of the technical condition, the mathematical model for evaluation and prognosis of the lubricant degradation process based on the balance between the formation and loss of wear products, for the evaluation of technical condition (serviceable, limit and emergency conditions), and the design of the optimal system of implementation of tribodiagnostics of selected engines.
Detection of Human Papillomavirus infection in oral mucosal diseases: a single-center study
Authors: Fantozzi Paolo Junior , Romeo Umberto , Tenore Gianluca , Palaia Gaspare , Ciolfi Chiara , Pierangeli Alessandra , Gioia Cira Rosaria Tiziana Di , Villa Alessandro
Published: April 2023

Background: Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers, but only a small proportion of oral potentially malignant disorders and oral squamous cell carcinoma. The aim of our study was to investigate the presence of HPV-DNA in oral diseases.Methods: This was a cross-sectional-study of 99 adult patients seen for the evaluation of oral diseases. All patients received an oral biopsy/histopathological examination and a brush biopsy for HPV-DNA detection/genotyping by real-time polymerase-chain-reaction. Immunohistochemistry was used to assess p16INK4a expression. P values were considered significant at P < 0.05.Results: HPV was identified in 15/99 (15.2%) patients (males:66.6%). Patients with oral lichen planus (OLP;23.8%), oral leukoplakia (OL;17.5%), and conditions of the buccal mucosa (BM;17.5%) had the highest rate of infection. Most patients with high-risk-HPV infection presented with OLP (19.1%), whereas most of the patients with low-risk-HPV infections had epithelial hyperkeratosis-non-reactive (9.4%). Amongst all benign lesions, 19.0% were positive for any HPV infection. One patient with OL showing mild-epithelial-dysplasia had a positive p16INK4a expression.Conclusions: The highest rate of HPV infection was in male patients, patients with OL/OLP, and in conditions of the BM. Larger studies are needed to elucidate the role of HPV in the development of these conditions.
Evaluation the Impact of Prescribed Metformin on Health-related quality of Life: A Cross- sectional Study
Authors: Bahadori Fatemeh , Sadatmahalleh Shahideh Jahanian , Montazeri Ali , Nasiri Malihe , moieni Ashraf
Published: April 2023

Introduction: Metformin is commonly prescribed to manage polycystic ovary syndrome (PCOS), which is one of the most common endocrine disorders among women of reproductive age, and is associated with high prevalence rates of psychiatric disorders.
This study’s objective was to determine the impact of metformin on psychosocial wellbeing in terms of mental health issues which affect the QoL among Iranian women with PCOS.
Materials and Method: The present cross-sectional study was carried out on 400 patients diagnosed with PCOS and equally divided 200 respondents into with metformin group and remaining 200 respondents into without metformin group. All participants were asked to fill out the valid and reliable questionnaires of FSFI (Female Sexual Function Index), HADS (Hospital Depression and Anxiety Scale) and SF-12.
Results: There were statistically significant difference between without metformin and with metformin in terms of arousal, lubrication, pain and total FSFI score. There were statistically significant difference between the mean score of MCS, anxiety and depression in without metformin and with metformin (P<0.001).
Conclusion: Metformin may have a role in the management of psychosocial wellbeing among patient with PCOS; however, its potential effects should be further examined in randomized double-blind placebo-controlled clinical trials.
Mitigation of Interference using HH-NBC,TDMA and Sea-lionoptimization techniques in Underwater Sensor Networks
Authors: B Shunmugapriya , A Shenbagharaman , B Paramasivan , B AnandhaMathavan
Published: April 2023

In order to better understand the vast aquatic environment, research on wireless sensor networks underwater has recently been done a lot of research in academia and industry. The Underwater world can easily observe remotely from an unknown location with some risks. The UWSN technology is employed over a water body to watch and surveillance. In large water bodies like rivers, salt chuck and huge pools, the data is accumulated from the region of various high points and drops of the level of the water, then dispatched to the exterior sink. Underwater transmission differs from terrestrial communication because of its high fading and low communication range.In place of this, a phonic medium is positioned to transfer data more efficiently on the water surface than other methods. To communicate and send the information accurately from the underside about the ocean to the sinks from the surface,hop growing is implemented using different techniques. Routing and Energy Efficiency is considered a highly challenging area of UWSNs. Energy-efficient routing is regarded as the foremost difficult task. Sensor networks primarily operate in complex and dynamic environments, and routing becomes tedious because the network size increases. In an underwater sensor network, there are so many challenges. Still, interference is a significant issue in transmitting signals in our proposed work to overcome signal interference using various approaches. Our proposed work follows: first, nodes will deploy in a non-distribution manner, then all nodes are clustered, and a cluster head has been chosen using the HH NBC algorithm. Finally, to overcome signal interference using TDMA combined with sea lion optimization. In this paper, we overcome inter-channel interference avoidance. If you overcome signal interference to improve network performance and lifetime. We compare our proposed to existing algorithms, and simulation results are best to compare with existing ones.
Trade-offs between hydropower and irrigation in transboundary river systems: the implications of further development on the Blue Nile in Ethiopia
Authors: Murgatroyd Anna , Wheeler Kevin , Hall Jim , Whittington Dale
Published: April 2023

We evaluate the implications of constructing one or two large dams upstream of the Grand Ethiopian Renaissance Dam (GERD), possibly in combination with new irrigation schemes upstream of these Blue Nile hydropower facilities. Two new dams could increase average annual hydropower on the Blue and Main Nile by almost 50% (30.2 TWh/yr to 44.7 TWh/yr). A system-wide analysis of the expected financial benefits of various development scenarios reveals little financial justification for substantial irrigation water withdrawals upstream of the GERD and multi-dam cascade. Withdrawing 5 billion cubic meters annually upstream of the GERD would reduce basin-wide hydropower by 3.3 TWh/year; withdrawing this volume above three dams would cause a 6.8 TWh/yr reduction. 1 (5) bcm/yr of withdrawals upstream of the three dams would reduce the reliability of meeting a 55.5 bcm/yr release target from the High Aswan Dam Reservoir by 3 (37) %.
Field parcellation of the human hippocampus along the longitudinal axis
Authors: González-Arnay Emilio , Jiménez-Sánchez Lorena , Pérez-Santos Isabel , Cid Elena , Gal Beatriz , Prida Liset M. de la , Cavada Carmen
Published: April 2023

The primate hippocampus includes the dentate gyrus, cornu ammonis (CA), and subiculum. CA is subdivided into four fields (CA1-CA3, plus CA3h/hilus of the dentate gyrus). with specific pyramidal cell morphology and connections. Work in non-human mammals has shown that hippocampal connectivity is precisely patterned both in the laminar and longitudinal axes. One of the main handicaps in the study of neuropathological semiology in the human hippocampus is the lack of clear laminar and longitudinal borders. The aim of this study was to explore a histochemical segmentation of the adult human hippocampus, integrating field (medio-lateral), laminar, and antero-posterior longitudinal patterning. We provide criteria for field parcellation of the human hippocampus based on the use of Rph3a, PCP4, Chromogranin A and RGS-14 immunostaining. We also provide novel histological data about the composition of species-specific regions of the rostral and caudal ends of the human hippocampus. The data are given with stereotaxic coordinates along the longitudinal axis. This study provides novel insights for a detailed region-specific parcellation of the human hippocampus useful for human brain imaging and neuropathology.
A meshless P1-Lagrange Interpolation operator in Rd
Authors: benmensour Khadidja , pousin jerome
Published: April 2023

Generally, meshless interpolations are not polynomial, in this paper, we propose a meshless polynomial local interpolator. This interpolator uses Lagrange polynomials P1 and a nearest neighbors strategy, and have yet been introduced in a previous work [1] investigating the relation between an artificial neural network and the transport of the identity towards a given function to be interpolated. Unfortunately, it has been reported in [1] that the order of convergence of the interpolation deteri- orates when the size of the d-simplexe becomes too small, because the built d-simplexe does not necessary contain the point at which inter- polation is computed. The aim of this note is to remedy this difficulty. Here, we study the problem of interpolating d-dimensional data with P1 polynomials by minimizing a data-fidelity cost function, involving the barycentric coordinates of the d + 1-nearest neighbors. Data points dis- tributions are not required to be structured, and the nearest neighbors are computed through a penalized minimization process in order to get a no degenerate d-simplex containing the point at which the interpolation is computed. The proposed interpolation operator is local, and a global one can be built which will be no more polynomial. Some numerical results are provided showing the efficiency of the proposed method.
S-Wave Spectra of Ω0c Baryon in a Relativistic Dirac Formalism using the Independent Quark Model
Authors: Patel Rameshri , Shah Manan , Vinodkumar P. C.
Published: April 2023

In this article, we investigate the S-wave of Ω0c baryon in the relativistic Dirac formalism. The spectroscopy is performed using the independent quark model(IQM). The spin-average masses are obtained by summing the individual Dirac energies of the constituent quarks under the mean field confinement of Martin-like potential with a parametric center of mass correction. We find the spin-average masses of low-lying S-wave and the spin degeneracy is removed by considering the spin-spin (j · j) interactions. The best-fitted potential parameters yielded the estimation of the ground state masses in very good agreement with experimental data. The computed masses of 1S( 3/2+), 2768.84 MeV and 1S( 1/2+), 2698.14 MeV are very close to the experimentally observed states. We also predict the experimentally observed state Ω0C(3120) is 3102 MeV as 2S( 3/2+) state. Higher S state doublets are also predicted which will be useful for the identification of future experimental data.
Density, apparent viscosity, electrical conductivity, interfacial tension, and intermolecular interactions of PEG-ZnCl2-EG solution
Authors: Liu Xunwei , Liu Kun , Yao Chang , Deng Dedan , Tian Chang
Published: April 2023

Herein we report the thermodynamic and transport properties of a polymer-DES solution. The density, apparent viscosity, electrical conductivity, and interfacial tension for the mixtures of poly (ethylene glycol) (PEG)/zinc chloride (ZnCl2)/ethylene glycol (EG) with various compositions were determined experimentally in the temperature range of 303.15 to 343.15 K. The variations of density, apparent viscosity, electrical conductivity, and interfacial tension with the temperature, PEG concentration, molar ratio of ZnCl2 to EG, and PEG molecular weight were analyzed and interpreted with the variations of H-bond, molecular thermal motion, polymer chain “end” effect, and polymer chain entanglement. The results showed that the hydrogen bond effect displayed enhancement with molar ratio of ZnCl2/EG and weakening with temperature, PEG concentration and molecular weight. The polymer chain “end” effect was enhanced with PEG concentration and weakened with PEG molecular weight. The effect of polymer chain entanglement was enhanced with PEG concentration and molecular weight. At low temperatures the Zn2+-EG H-bond was stronger than Zn2+-PEG while the situation became opposite at high temperatures. The correlations of density, apparent viscosity, and electrical conductivity with temperature and correlation of viscosity with density were conducted and the results showed that the activation energy of viscosity Eη showed increase while the activation energy of conductivity Eκ displayed decrease with the molar ratio of ZnCl2/EG and the closed-packed volumes of the PEG/ZnCl2/EG mixtures displayed increases with PEG concentration.
A gene signature predicting prognosis of patients with low- grade gliomas receiving temozolomide therapy
Authors: Wan Yanzhi , Li Guangqi , Deng Junyue , Ma Xuelei
Published: April 2023

Temozolomide (TMZ) has been used as a first-line therapy against low-grade gliomas (LGGs) combined with other chemotherapy drugs. However, there has been no reliable index predicting TMZ response of patients with LGGs. In this study, we aim to investigate the relationship between gene expressions and the prognosis of TMZ therapy in LGGs. We integrated transcriptome and clinical data of 171 LGGs from the Chinese Glioma Genome Atlas (CGGA). Consensus LASSO Cox regression was used to identify 14 key genes related to different clinical outcomes under TMZ chemotherapy. We constructed and evaluated a risk score based on the 14 genes. Patients with LGGs of lower risk scores (low-risk group) generally had better survival than those LGGs of higher risk scores (high-risk group), which is independent of clinicopathological factors. High-risk patients showed activation of innate and humoral-type immunity. The prognostic contribution of the risk score was validated in an independent validation cohort of 65 patients. Besides, combined with three independent predictors (grade, IDH1 mutation status, and chr1p19q co-deletion status), we further developed a nomogram to predict the benefit from TMZ treatment in LGGs. Our results indicate that transcriptome-based index can optimize the treatment strategy for patients with LGGs under TMZ therapy.
GPS data were used to study the interseismic slip distribution and locking characteristics of the mid-southern segment of the Tanlu fault zone
Authors: YU SHUYUAN , LIU ZEMIN , LI LAYUE , ZU LIANGYU , YANG YUANYUAN , LUO JIAJI
Published: April 2023

The central and southern section of Tanlu fault zone is a section with frequent seismic activity and dense population distribution.Along the fault are infrastructure such as high-speed rail and the South-north Water Diversion project, as well as world heritage sites such as the Grand Canal, ancient city ruins and cultural landscapes. If a strong earthquake occurs in the future, it may cause great social impact and property losses.It is necessary to have a clear understanding of the current activity characteristics and potential seismic risk of fault zone to reduce the loss of earthquake disaster scientifically and reasonably.However, there are few data on its current activity characteristics through geodetic data.Based on GPS observation data from 1991 to 2020, the characteristics of fine slip distribution between present earthquakes in the mid-southern segment of the Tanlu fault zone are retrieved based on the fastest descent method. On this basis, the lock degree and slip rate deficit characteristics of this section are obtained；Finally, by comparing the surface strain results from 1991 to 2007 and 2013 to 2020, the differences of deformation characteristics between the two phases of the mid-southern segment of the Tanlu fault zone are analyzed.The results show that the interseismic sliding rate of the mid-southern segment of the Tanlu fault zone is 0 ~ 1 mm·-1，In the northern Tancheng-Sihong section, it showed right-handed thrust, and the sliding rate was between 0.2 ~ 1 mm·-1；The Sihong - Tongcheng section of the southern section is dextrorotally stretched, and the sliding rate is between 0 and 0.5mm.The degree of blockage in the mid-southern segment of the Tanlu fault zone is segmented along fault strike.In the north section, the locking depth of Changyi-Tancheng section was relatively high, with the deepest reaching 32 km,and the maximum compression-slide loss rate reaching -1mm·a-1；Tancheng-Wangji closure coefficient decreased significantly, with a concentrated distribution between 0.2 and 0.7. The Wangji-Jiashan section has a high degree of closure, small and medium earthquakes are not active, and it is the unruptured section, which is more prone to stress accumulation.
Goodwill, Earnings Predictability and Stock Mispricing: An Empirical Study on Agency Cost View
Authors: Jiang Allen
Published: April 2023

Existing literature reports that a company’s goodwill is not the higher the better. But is the value of goodwill affected by agency costs? Do investors understand the difference in the value of goodwill under different agency costs? These two questions are still unresolved. This paper studies the above questions from the influence of goodwill on the predictability of earnings and whether the stock price correctly reflects this influence, and uses the Mishkin model to test the effectiveness of the stock market in identifying the value of goodwill. This paper finds that higher book value of goodwill significantly reduces the predictability of earnings, especially when the agency costs of managers and major shareholders are high. But this fact is not understood by the market and leads to the mispricing. The mispricing will be corrected by the market from the second year, resulting in the reversal of stock returns. The results of this paper show that serious agency issues will lead to accounting information being distorted due to improper implementation of accounting standards, thereby affecting the efficiency of the stock market.
The effect of hypertensive diseases on death patterns and healthy ageing in Pudong, Shanghai: a population-based study
Authors: Zou Jian , Wang Qizhe , Chen Yichen , Zhou Jing , Liu Ru , Xu Yaxin , Peng Minghui , Li Xiaopan , Liu Ming , Jiang Sunfang
Published: April 2023

Hypertensive diseases (HT) have become one of the leading causes of death among older people in developing countries, but data on HT-related deaths and HT-specific deaths in the whole population in the context of healthy ageing have not been well studied. We analysed the HT-related death and HT-specific death spectrum, crude mortality rate (CMR), age-standardized mortality rate by Segi’s world standard population (ASMRW), years of life lost (YLL) and age-specific proportion and then used the Joinpoint Regression Program to analyse the trends. We also studied the mortality rate increases by demographic age structure factors by the decomposition method. Of all 110,393 HT-related deaths, there were 5,757 HT-specific deaths in Pudong, Shanghai, from 2005–2020. The CMR, ASMRW, YLL and YLL rates of HT-related deaths (and HT-specific deaths) were 244.73/105 (12.76/105) person-years, 79.86/105 (4.22/105) person-years, 846,645.55 (43,912.98) years and 1,876.94/105 (97.35/105), respectively. The top 3 common causes of death among HT-related deaths (and HT-specific deaths) were cerebrovascular disease (heart disease), heart disease (renal failure) and diabetes mellitus (cerebrovascular disease). The HT-related and HT-specific CMR increased with age and year (all P < 0.05). The age-specific mortality rates decreased in age group 70–79 years, while in other groups, they increased or stabilized. The CMR caused by demographic age structure factors increased in the two groups (all P < 0.05). Our study provides new insights into the mortality trend of HT in a hyperaged society. As a common disease among older people, the burden of HT requires further study to meet the needs of healthy ageing.
Friction and Neuroimaging of Active and Passive Tactile Touch
Authors: Zhou Xue , Li Yiyuan , Tian Yu , Masen Marc A. , Li Yuanzhe , Jin Zhongmin
Published: April 2023

Two types of exploratory touch including active sliding and passive sliding are usually encountered in the daily life. The friction behavior of the human finger against the surface of objects is important in tactile perception. The neural mechanisms correlating to tribological behavior are not fully understood. This study investigated the tactile response of active and passive finger friction characterized with functional near-infrared spectroscopy (fNIRS). The friction test and fNIRS test were performed simultaneously using the tactile stimulus of polytetrafluoroethylene (PTFE) specimens. Results showed that the sliding modes did not obviously influence the friction property of skin. While three cortex regions were activated in the prefrontal cortex (PFC), showing a higher activation level of passive sliding. This revealed that the tribological performance was not a simple parameter to affect tactile perception, and the difference in cortical hemodynamic activity of active and passive touch was also recognised. The movement-related blood flow changes revealed the role of PFC in integrating tactile sensation although there was no estimation task on roughness perception.
Prevalence and Determinants of Under-Five Malnutrition in Borana Zone of Oromia Region, Ethiopia: Effects of a Prolonged Drought
Authors: Kamangira Boboh , Ayele Gudeta , Melaku Kaleb , Dube Polite , Vushoma Eubert
Published: April 2023

Background Evidence-based health and nutrition findings have a crucial role in improving the level of the problem and associated mortality reduction in children. With Borana experiencing a prolonged drought, our study sought to both update estimates and determinants of malnutrition in the zone and assess the impact of the drought on these estimates and determinants in order to inform drought response strategies.Methods A cross-sectional study was conducted among children under five years in Borena Zone from August 16 to September 03, 2022 using multistage cluster sampling technique. Data was collected by a structured questionnaire and anthropometrical measurements. The collected data was exported into STATA 15 for analysis. Multivariable logistic regression analysis was used to identify the factors associated with malnutrition.Results A total of 537 children aged from 6 months up to 59 months and their caregivers were included in the study. The prevalence of stunting, underweight and wasting was 40%, 33.5%, 27.6% respectively. The 12–24 months age group (AOR: 0.51, p = 0.021), unimproved water sources (AOR: 1.93, p = 0.003), and history of diarrhea in the two weeks prior to the survey (AOR: 1.66, p = 0.05) were independently associated with acute malnutrition. Moreover, living in urban areas (AOR: 1.68, p = 0.007), access to diversified food (AOR: 0.67, p = 0.046) and feeding frequency (AOR: 0.43, p = 0.044) were independent predictors of chronic malnutrition.Conclusion There was a higher prevalence of stunting, wasting, and underweight in Borena Zone than the national malnutrition prevalence. Community based nutrition programs need to be established to tackle the problem of malnutrition and exacerbate the impact of a prolonged drought in Borana. Interventions should be focused on improving household food security, use of improved water sources, and nutrition education to diversify child diet.
Hsa_circ_0105040 promotes Cutbacterium acnes biofilm induced inflammatory via sponge miR-146a in human keratinocyte
Authors: Liu Yuzhen , Zhou Meng , Zheng Nana , Xu Haoxiang , Chen Xu , Duan Zhimin , Lin Tong , Zeng Rong , Chen Qing , Li Min
Published: April 2023

Background Circular RNAs (circRNAs) are thought to play a crucial function in controlling gene expression, according to expanding findings. However, the importance of circRNAs in the regulation of acne inflammation is unclear.Methods Microarray analysis has been carried out to investigate circRNAs/miRNAs/mRNAs that express abnormally in acne. RNase R digestion assay is used for confirmation of the hsa_circ_0105040 characteristic. The functional roles of hsa_circ_0105040 on inflammatory response induced by Cutibacterium acnes (C. acnes) biofilm in human primary keratinocytes were revealed by Fluorescence in situ hybridization (FISH), Reverse transcription quantitative (PCR), Western blotting analysis, Immunoprecipitation, Luciferase reporter assay, Biotin-labeled miRNA pull-down assay, RNA immunoprecipitation (RIP).Results We first evaluate the human circRNA expression patterns in acne tissues and find that hsa_circ_0105040 expression is considerably reduced in acne tissues. Moreover, we discover that the majority of hsa_circ_0105040 is found to be localized in the cytoplasm of primary human keratinocytes. Hsa_circ_0105040 overexpression significantly enhances the production of proinflammatory factors (interleukin-8, interleukin-6, and tumor necrosis factor-α). Mechanistic research reveals that the microRNA miR-146a binds to hsa_circ_0105040, which then actively sponges miR-146a to prevent the level of IRAK1 and TRAF6.Conclusions These findings point to hsa_circ_0105040 as a critical circRNA that function as "microRNA sponges" for the controlled inflammatory response in the development of acne. Our findings may provide valuable insights into the progression of acne.
B, N Co-doped Wood Scrap Charcoal for High Supercapacitor with Decorated Conductivity
Authors: Chen Gaojun , Li Yudong , Han Enshan , Zhang Ziqiang , Yang Xiaohui , Zhou Desheng , He Yanzhen
Published: April 2023

The optimization of supercapacitive properties in carbon materials derived from cheap and sustainable wood scrap exhibits great application potential. Herein, in support of interfacial groups, polyaniline nanospheres were in-situ constructed in the internal pore structure of wood scraps, further the B and N element were imported by carbonized and hydrothermal. The doped B regulated the species of N-doping to improve the electrical conductivity of carbonized wood scraps, and endowed a certain pseudo-capacitance. Coupled with the fine double-layer capacitance from the hierarchical structures constructed by carbonized nanospheres and wood scrap channels, high specific capacitance of 406 F g-1 at 0.5 A g-1, high energy density (17.71 Wh kg-1 at 250 W kg-1) and cycle stability (93.04% capacitance retention after 10000 cycles) performed simultaneously. This study provided a new strategy to improve the supercapacitive performance of bio-carbon materials in terms of structure and conductance.
Survival rate and chronic diseases of TCGA cancer and KoGES normal samples by clustering for DNA methylation
Authors: Gim Jeong-An
Published: April 2023

Background
Insights from public DNA methylation data derived from cancer or normal people can be obtained by machine learning. The goal is to determine the methylation pattern for predicting the prognosis for cancer patients and correcting lifestyles for normal people.
Methods
DNA methylation data were obtained from 446 healthy participants of 11 TCGA carcinomas, the Korean Genome Epidemiology Study (KoGES). For males and females, respectively, data from TCGA and KoGES were merged. To correct for the batch effect, R's ComBat function is used. Using the K-mean clustering (k = 3), the survival rates and chronic diseases were confirmed between the three groups of TCGA and KoGES.
Results
In a total of 82 female pancreatic cancer (TCGA-PAAD) patients and 220 normal participants, cluster 1 and 3 groups were compared. The survival rate in cluster 3 was significantly lower than in cluster 1. Among normal participants, the odds ratio according to the presence or absence of hypertension in two clusters was 2.18.
Conclusion
Based on the public DNA methylation and clinical data of normal participants and cancer patients, an analysis pipeline that integrates and clusters were provided. As a result of clustering, genes that explain survival and chronic disease were presented.
Contrasting emission trends between the two phases of China’s clean air actions from 2013–2020
Authors: Zhang Qiang , Geng Guannan , Liu Yang , Cheng Jing , Yan Liu , Liu Yuxi , Wu Nana , Hu Hanwen , Tong Dan , Zheng Bo , He Kebin
Published: April 2023

China’s clean air actions since 2013 have led to dramatic changes in air pollutant emissions and surface air quality. Here, we investigated the trends and drivers of air pollutant emissions during the two phases of clean air actions (i.e., Phase I from 2013–2017 and Phase II from 2018–2020) in China. We estimated decreasing trends of nonmethane volatile organic compound (NMVOC) and NH3 emissions after 2017, representing the success of targeted policies for these pollutants during Phase II. However, regarding other pollutants, the emission reduction during Phase II were slowing down compared to those during Phase I. Although Phase II emphasized structural adjustment, end-of-pipe emission control measures remained the major drivers of emission reduction throughout the two phases. We thus recommend more active structural adjustment policies targeting the transition of the energy system in China.
Research on Abrasive Flow Polishing Technology and Quality Control of High Performance Impeller Surface
Authors: Li Junye , Tang Jiaxu , Liu Jianhe , Qu Jiyong , Zhang Xinming , Xu Chengyu
Published: April 2023

The rapid development of science and technology puts forward higher requirements for the quality and accuracy of high-performance impeller parts. In order to improve the machining accuracy of the inner surface and enhance the uniformity of the whole structure, In this paper, the large eddy simulation method is used to simulate and analyze the abrasive flow machining process of the high performance impeller with different machining parameters. Then the three processing parameters of inlet pressure, inlet speed and abrasive viscosity are simulated numerically. The results show that increasing the inlet pressure and abrasive viscosity can effectively improve the processing effect. Increasing the inlet speed will improve the processing intensity, but the overall processing uniformity will be reduced. The experiment result shows: The inlet pressure and particle size have a significant impact on the abrasive flow machining effect, followed by the number of machining times, and the surface roughness of the high-performance impeller after abrasive flow machining can reach 0.052µm, and the best technological parameters determined by the experimental research can realize the uniform polishing of the high performance impeller by abrasive flow machining technology.
Effective techniques for classifying ADHD based on artificial intelligence
Authors: salah eman , Shokair Mona , Shalaby Wafaa
Published: April 2023

Attention Deficit Hyperactivity Disorder (ADHD) has become widespread globally and is found in everyone's home, as it appears from birth, especially if it was premature. The people who suffer most from all its consequences are the parents. It is a widespread psychiatric disorder with persistent patterns of inattention, hyperactivity, and impulsive behavior among children. The dangerous factor is that these children are often involved in learning difficulties that tend to frustrate them as they reach adulthood [1]. This paper uses an effective method to identify ADHD at an early age using Functional Magnetic Resonance Imaging (fMRI) data. The proposed method by which the disease is detected automatically will be presented. Convolutional neural networks (CNNs) are used to extract the features of the images, thus reaching an optimal solution to identify this disorder. Our model includes a set of layers, specifically 23 layers. Besides, for each dataset, the performance of the proposed scheme will be studied for different optimization algorithms, micro-batch size values, and learning rates. In the experimental results, a comparison of the adaptive moment (ADAM), stochastic gradient ratios with momentum (SGDM), and principal squared property (RMS prop) optimizers will be performed for the fMRI datasets. By using these optimization techniques to adapt the ADHD case classification system, it will be concluded that the accuracy of RMS prop gives high accuracy than ADAM and SGDM. Moreover, the proposed method achieves an accuracy of 97.78% compared with the Reset method of 95.65% and the Google -Net method of 92.22%.
Spectral coherence of soil thermal conditions and a stochastic inverse solution for thermal conductivity in the shallow vadose zone of Quaternary gravel formation
Authors: Shih David Ching-Fang
Published: April 2023

Due to the heterogeneity in the unsaturated or vadose zone, it is challenging to represent the analytical mechanism and actual in-situ water content in the soil layer. However, in the shallow layers, thermal conditions quickly change with surface temperature evolution. It expects that the water content can, more or less, be affected by the in situ heat mechanism. This research, therefore, suggests a novel design to theoretically discover the thermal conditions, such as soil temperature, soil temperature gradient, and heat flux in the shallow Quaternary gravel layer at various depths using spectral analysis of temporal observations. In addition, this research proposes a stochastic inverse solution of thermal conductivity using spectral estimation of soil heat flux and temperature gradient. It suggests that the most apparent periodic fluctuations of the thermal condition are in the diurnal process for 24 hours. The soil temperature gradient and heat flux at 10, 30, 60, and 120 cm depths can catch soil temperature and air temperature changes to some degree in the frequency domain. The thermal conductivity ranges from about 5.44 to 0.41 W/(m°C) for the soil depths from 10 to 120 cm using the spectral inversed solution. Thus, using spectral analysis, assessing the soil layer's thermal conductivity and other thermal conditions becomes feasible and achievable.
Cancer Incidence in Khyber Pakhtunkhwa, Pakistan, 2020
Authors: Badar Farhana , Sohaib Mohammad , Mahmood Shahid , Chughtai Omar Rasheed , Sultan Faisal , Yusuf Muhammed Aasim
Published: April 2023

Background: To present the population-based cancer statistics for Khyber Pakhtunkhwa (KP), Pakistan, an incidence study was conducted at the Shaukat Khanum Memorial Cancer Hospital and Research Center (SKMCH&RC) in Lahore, Pakistan, in 2023.
Methods: Records from various centers on new cancers diagnosed in residents of KP between January and December 2020 were gathered. Both the active and passive methods of data collection were applied, and the information was saved in a central repository at SKMCH&RC. The incidence rates were computed by age group and sex and presented per 100,000 population.
Results: Among children (0-14 years), the age-standardized incidence rate (ASIR) was 4.0 in girls and 6.1 in boys, and hematologic malignancies were more prevalent; in adolescents (15-19 years), the ASIR was 7.7 in females and 9.4 in males, and bone tumors, hematologic malignancies, and neurological cancers were prominent; in adult females (>/= 20 years), the ASIR was 84.9, and cancers of the breast, digestive system, and reproductive organs were predominant; and in adult males, the ASIR was 73.0, and cancers of the gastrointestinal tract, lip/oral cavity/pharynx, and prostate were common.
Conclusions: It is crucial to investigate the etiology of these diseases at the community level because dietary elements, infectious diseases, and tobacco use all appear to be significant contributors. Prospective studies could play a key role in highlighting the factors linked to these diseases. Therefore, cancer registration must continue in conjunction with the exploration of risk factors.
Counterfactual coercion: Could harsher sanctions against Russia have prevented the worst?
Authors: Niemeier Thies , Schneider Gerald
Published: April 2023

Recent studies show that properly designed economic sanctions can force the target to refrain from violating international norms. However, policy-makers are not enabled to integrate this finding in their ex ante assessments whether more intensive coercive measures could prevent military coups, human rights violations, or a war of aggression such as the Russian invasion of Ukraine. In this article, we address this shortcoming of the conflict forecasting literature and introduce counterfactual predictions to answer the what if-question of whether adequate sanctions by the European Union and the United States could have provoked targets to abandon severe norms violations. To this end, a training data set for the period from 1989 to 2008 is used to predict the incidence, intensity, and success of sanctions from 2009 to 2015. Our policy counterfactuals for key sanction cases demonstrate that stricter EU coercion against Russia after the annexation of Crimea could have triggered policy concessions from the regime of President Putin.
A Coffin Dispersed: Case-study of 21st Dynasty Coffin Fragments (Timişoara 1142-1146, Budapest 51.325)
Authors: Anđelković Branislav , Teeter Emily
Published: April 2023

Study of the iconography and texts on sections of a 21st Dynasty coffin in the collection of the Museum of Banat in Timişoara, Romania, shows that the vignettes as well as the texts are unusual for such coffins. A notable feature is that the deceased is nowhere shown on the fragments, and bands of text (that on other coffins end with the name of the deceased) fill the entire area leaving no room to add the personal name. The lack of a name, the corrupt texts, unusual iconography, and the lack of varnish may reflect the lack of resources of the coffin’s owner. A fragment in Budapest (51.325) is shown to join the Timişoara coffin sections. The dismantling/sawing of an object to make it more portable and saleable reflects an established practice of late 1800s and early 1900s Egyptian antiquities market.
French Influence in the Bay of Kotor at the End of the 18th and the First Years of The 19th Century: The Activities of Mirislav Zanović
Authors: Kocić Marija
Published: April 2023

The paper discusses the activities of Mirislav Zanović, the leader of the pro-French political faction in the Bay of Kotor at the end of the 18th and the first years of the 19th century. This research indicates that the first reliable data on his pro-French orientation date back to the end of 1793. At that time, the general providor of Dalmatia, Alvize Marin, was warned about individuals in Boka, who were suspected of feeling sympathy towards the Revolution and its ideas. In October 1795, Mirislav tried to launch a rebellion, motivated by the ideas of brotherhood and freedom. This revolt was aimed at liberating certain areas on the border from Ottoman servitude. It was quelled, while Mirislav was kept in prison for some time, in Venice. He was released after the French conquered the city and sent to Budva to propagate the ideas of the Revolution and work to win over the local population.

The paper also discusses its position during the first Austrian (1797–1805), Russian (1806–1807) and French (1807–1813) rule in Boka. Although the Austrian authorities harbored suspicion of Mirislav, he managed to survive thanks to the influence of his father, Count Antun Zanović, who was appointed manager of Budva. Mirislav found himself in the most difficult position during the Russian rule, when he spent some time in prison. He reached the peak of his rise in the political life of Boka during the French rule, when he was appointed to certain administrative positions in Budva. After France lost all illusions about the possibility of the survival of its government in Boka, Mirislav, thanks to good relations with Bishop Petar I Petrović-Njegoš, changed sides in 1813, denying any support to France. In the years that followed, Mirislav was relegated to the background. He spent a short time in prison in Dubrovnik, after which he was released, but was placed under surveillance by the Austrian authorities for the rest of his life.
The Hajj – Adapting the Global Islamic Ritual to Pandemic Conditions
Authors: Vukomanović Milan
Published: April 2023

This paper looks at how the Muslim pilgrimage to Mecca (the Hajj) adapted to the novel circumstances created by the COVID-19 pandemic in 2020 and 2021. The pandemic has been an entirely novel and, probably, dominant liminal situation which has significantly affected the behavior of the faithful and the way in which their individual identity has been transformed, at least in the psychological sense. Following an introductory overview, which provides a brief description of the ritual process of the Hajj, the author briefly looks at the various ways of travel to Saudi Arabia from a historical perspective, as well as at new technical and health aspects which entailed the adaptation of this global ritual to pandemic conditions. Rituals are, undoubtedly, deeply connected to human psychological, but also social needs and inclinations, and help preserve functionality in dysfunctional situations such as natural disasters or the spread of new diseases. Similarly, they provide a safe zone in conditions of drastic and unwanted change. The paper therefore points out the very specific type of ambivalence which accompanies the fact that the natural human reaction at times of crisis is to "close ranks", which became extremely difficult or practically unfeasible in conditions of social distancing implemented as a measure to prevent the spread of the coronavirus in 2020-21. The conclusion highlights the fact that the latest experience with COVID-19 has had medical, economic, social, political, psychological and religious implications with long-term consequences for the organization of the Hajj.
COVID-19 Vaccine Refusal in Serbia as an Example of Social Solipsism
Authors: Žikić Bojan
Published: April 2023

The number of citizens in Serbia vaccinated against COVID-19 was among the highest in Europe in early 2021. It started to stagnate as it approached 50% total population coverage, while the number of cases started to rise. The paper presents the cultural thought that leads people to decline COVID-19 vaccination, and aims to show that such cultural thought can be described as social solipsism. This means that illusions about reality are used as a cognitive reference point for organizing the world around us.

It has been noted that there is no uniform category of opponents of the fight against the pandemic. There are those who, in their negative attitude to everything that is being undertaken to curb the pandemic, are led by the idea that the illness does not exist; then there are those who are opposed to vaccination in general, but also those who oppose only COVID-19 vaccination; in addition, there are those who prioritize their own principles based on legal, moral or religious norms over vaccination, interpreting those norms in this way, and those who believe that their lifestyle and state of health protect them from illness, and that this, rather than vaccination, should be the guideline for the fight against the pandemic; then there are those who are doubtful about everything they read and hear in the media about COVID-19, as well as those who are unable to provide a more specific explanation about the reasons for refusing to be vaccinated, and those who have lost all trust in politicians, i.e. in the way that our society has been organized under the influence of state and social actors; then, there are those whose trust in the medical profession has declined.

Finally, there is a distinct subgroup of respondents, namely those who are able to put together a small pseudotheoretical system which links the pandemic as a global fact with events which may or may not be connected with it in the local, Serbian sociocultural context, in a manner which they perceive as being causal. What characterizes the cultural thought that leads them to refuse vaccination is distrust of the dominant social discourses, primarily political and scientific and, above all, medical discourses, and they consequently ignore the objective facts these discourses are based on. Such cultural thought can be termed postlogical because it ignores those social discourses – primarily scientific ones – which talk about the objective state of factual reality; instead, it draws on arguments that are not characteristic of causal, factographically informed thought, influencing public opinion by appealing to convictions and feelings rather than facts.