bluuebunny/crossref_metadata_2025 huggingface dataset:
On the traces of lost identities: chronological, anthropological and taphonomic analyses of the Late Neolithic/Early Eneolithic fragmented and commingled human remains from the Farneto rock shelter (Bologna, Northern Italy)
Authors: Nicolosi Teresa , Mariotti Valentina , Talamo Sahra , Miari Monica , Minarini Laura , Nenzioni Gabriele , Lenzi Fiamma , Pietrobelli Annalisa , Sorrentino Rita , Benazzi Stefano , Belcastro Maria Giovanna
Published: July 2022

The present study examines the prehistoric human skeletal remains retrieved starting from the 20s of the XX century in the deposit of the Farneto rock shelter, situated in the area of the ‘Parco dei Gessi Bolognesi e Calanchi dell’Abbadessa’ (San Lazzaro di Savena, Bologna, Northern Italy). An exact dating and a reliable interpretation of the assemblage had not been reached so far because of the lack of contextual data useful for dating purposes, the inaccurate recovery procedures of the remains, as well as their state of preservation. In fact, the skeletal remains from the Farneto rock shelter are highly fragmented and commingled, whereas reliable information about their original position and their recovery procedures are not available. Despite these difficulties, radiocarbon analyses allowed to clarify the precise dating of the remains, which date back to a final phase of the Neolithic and an early phase of the Eneolithic period in Northern Italy, testifying an early use of natural cavities for funerary purposes in the area. Moreover, the anthropological and taphonomic study of the skeletal remains shed light on the biological profile of the individuals and on some events that occurred after their death. In particular, the analysis of peri mortem lesions highlighted the existence of intentional interventions related to corpse treatment, referable to dismembering/disarticulation and scarnification, i.e., cleaning of bones from soft tissues. Finally, the comparison with other Neo/Eneolithic funerary contexts in Central and Northern Italy enabled a better understanding of these complex ritual practices.
Association between the number of remaining teeth and need for long-term care or support needs among generally healthy older adults in Japan
Authors: Kakei Yasumasa , Kagimura Tatsuo , Yamamoto Yasuji , Osaki Tohmi , Kajita Hiroyuki , Kojima Shinsuke , Kowa Hisatomo , Kawabata Miyuki , Hasegawa Takumi , Akashi Masaya , Nagai Yoji
Published: July 2022

Objectives: Japan has the largest super-aged population worldwide. As long-term care and support for community-dwelling older adults have considerable healthcare and socioeconomic implications, population-based projects are exploring strategies for prevention and early detection of physical and cognitive decline. The Frail Kenshin health checkup program of Kobe city includes citizens aged 64 or 65 years. Materials and methods: Overall, 1508 subjects of the program between August 2017 and March 2018 were included. Frail Kenshin data were analyzed to examine associations between the number of remaining teeth with Cognitive Functional Instrument Self and European Quality of Life Five Dimension questionnaire scores, and near future long-term care need certification. The number of teeth was identified from the Frail Check data; mastication scores and number of chewable foods were also assessed.Results: Reduced numbers of remaining teeth were significantly associated with various measures of general frailty, including motor function, oral function, prevention of seclusion, memory, mental health, mastication scores, total number of chewable foods, and body mass index (p<0.001, all). They were also associated with decreased calf and standing up test scores, worsening in European Quality of Life Five Dimension visual analogue scale scores, degree of mobility, and regular activities (p<0.001, all). Decreased numbers of remaining teeth were associated with increased frequency of long-term care or support need certification (p<0.001). Conclusion: Loss of teeth appears to be associated with long-term care or support needs among community-dwelling older individuals. Clinical relevance: Community-dwelling older adults with loss of teeth require careful monitoring for long-term care needs.
Clinical feature analysis of pneumonia caused by Tropheryma Whipplei
Authors: Lin Jiaping , Ou Yang , Yu Xiaoling , Lai Yanjin , Lai Guoxiang , Chen Lihong , Wang Bin , Shi Yixian , Lin Xiuhua
Published: July 2022

Background: Whipple's Disease (WD) is a rare infection caused by Tropheryma whipplei (TW), which affects multiple organs. When the infection invades the respiratory system, severe respiratory failure can be induced. However, due to extremely low prevalence and insufficient awareness, the disease is easily ignored by practitioners. Recently, we found a case of severe pneumonia with TW infection with respiratory failure induced. We combined published cases to perform a retrospective analysis of the clinical features of pneumonia caused by TW, intending to provide a reference for the treatment of WD.Methods: 11 cases of pulmonary TW infection were retrieved from the literature (1992-2022). Together with the single case identified in our hospital, 12 cases were retrospectively analyzed for risk factors, clinical manifestations, diagnosis and treatment, and outcomes.Results: Pulmonary TW infection was more prevalent in middle-aged men without underlying diseases (9/12, 75%). It usually manifested as respiratory symptoms such as cough (6/12, 50%), dyspnoea (7/12, 58.33%), and chest pain (2/12, 16.67%), which can be accompanied by or only manifested as digestive system symptoms, joint pain, fever, and other extrapulmonary symptoms. Pulmonary imaging findings were nonspecific, presenting various alterations, including multiple ground-glass opacities, consolidations, nodules, cavities in both lungs, as well as pleural effusion, interstitial pneumonia, and acute fibrinous and organizing pneumonia. Based on traditional clinical experience, Pulmonary TW infection can be treated by standardized anti-infective therapies.Conclusions: The clinical manifestations and pulmonary imaging findings of Pulmonary TW infection were diverse and non-specific. Hence, it can be easily missed or misdiagnosed. Significant efficacy can be achieved with prompt diagnosis and effective medication, thus more attention should be paid to this disease. To our knowledge, this is the first retrospective study concerning the clinical features of Pulmonary TW infection to date. Nevertheless, the number of cases presented here was small, which requires the supplementation of more clinical data in the future.
Health economic evidence for adjuvant chemotherapy in stage II and III colorectal cancer: a systematic review
Authors: To Yat Hang , Gibbs Peter , Tie Jeanne , IJzerman Maarten , Degeling Koen
Published: July 2022

Objective: The aims of this study was to appraise the health economic evidence for adjuvant chemotherapy (AC) strategies in stage II and III colorectal cancer (CRC) and to identify gaps in the available evidence that might inform further research.Method : A systematic review of published economic evaluations was undertaken. Four databases were searched and full-text publications in English were screened for inclusion. A narrative synthesis was performed to summarise the evidence.Results: Thirty-eight studies were identified and stratified by cancer stage and AC strategy. The majority (89%) were full economic evaluations considering both health outcomes, usually measured as quality-adjusted life years (QALYs), and costs. AC was found to be cost-effective compared to no AC for both stage II and III CRC. Oral and oxaliplatin-based AC was cost-effective for stage III. Three months of CAPOX was cost-effective compared to 6-month in high-risk stage II and stage III CRC. Preliminary evidence suggests that biomarker approaches to AC selection in stage II can reduce costs and improve health outcomes. Notably, assessment of QALYs were predominantly reliant on a small number of non-contemporary health-utility studies. Only 32% of studies considered societal costs such as travel and time off work. Conclusions: Published economic evaluations consistently supported the use of AC in stage II and III colorectal cancer. Biomarker-driven approaches to patient selection have great potential to be cost-effective, but more robust clinical and economic evidence is warranted. Patient surveys embedded into clinical trials may address critical knowledge gaps regarding accurate assessment of QALYs and societal costs in the modern era.
The evolutionarily conserved gene Arrdc5 is required for male fertility
Authors: Oatley Jon , Giassetti Mariana , Miao Deqiang , Law Nathan , Oatley Melisaa , Park Julie , Maddison Lisette , Bernhardt Miranda
Published: July 2022

In sexually reproducing organisms, sperm contribute half the genomic material required for creation of offspring and natural fertility relies on males producing millions by way of spermatogenesis. This process is essential for continuity and diversity of a species, yet evolutionarily conserved core molecular regulators are undefined. Here we used single cell RNA-sequencing of testicular tissue from mice, pigs, and cattle to generate a multispecies integrated transcriptome database. Through bioinformatic analysis, the gene arrestin-domain containing 5 (Arrdc5) which encodes for an α-arrestin molecule was identified as a potential evolutionarily conserved regulator of spermatogenesis. Expression of Arrdc5 is testis specific in mice, pigs, cattle, and humans. Knockout of Arrdc5 in mice leads to male specific sterility due to production of low numbers of sperm that are immotile and malformed, resembling oligoasthenoteratospermia (OAT) which is a common diagnosis of infertility in men. Spermiogenesis, the final phase of spermatogenesis when round spermatids morphologically transform to spermatozoa, is defective in testes of Arrdc5 deficient mice. Also, epididymal sperm in Arrdc5 knockouts are unable to capacitate and fertilize oocytes. These findings establish ARRDC5 as a core regulator of mammalian spermatogenesis. Considering the role of arrestin molecules as modulators of G-protein coupled signaling and ubiquitination, ARRDC5 is a potential male contraceptive target.
Antimicrobial and antioxidative properties of Cleome viscose leaf extract
Authors: Sharma Hirdesh , Shrivastava Archana
Published: July 2022

The annual, sticky plant Cleome viscose Linn. (Capparidaceae), sometimes known as "Jakhya," thrives as a weed across India's plains and throughout the tropics. The entire plant and its components are extensively used in traditional and folklore medicine (seeds, leaves, roots and barks). We evaluated the antimicrobial and antioxidant capacity of Cleome viscose leaf extract.Methods: Methanol was used to extract the leaves. Extract was analysed qualitatively and quantitatively. Antioxidative properties of extract was assayed using DPPH, FRAP, ABTS H2O2 scavenging assay. Correlation between antioxidant activity, phenolic content and flavonoid content was estimated. Antimicrobial activity of Cleome viscose Linn leaf methanolic extract was estimated against Staphylococcus aureus, Vibrio cholera, Salmonella Typhimurium.Result: The methanolic extract of Cleome viscose leaves showed good antioxidant and antimicrobial potential. The extract was having alkaloids, phenolics, flavonoids and tannins as major phytochemicals. The extract showed good ABTS scavenging activity and moderate DPPH scavenging activity. The TPC strongly while TFC moderately correlated with antioxidant activity of the extract.Conclusion: Methanolic extract of Cleome viscose leaves demonstrated significant antioxidant and antibacterial activity. The phytoconstituents found in plant leaves, primarily phenolics, flavonoids, alkaloids, and tannins, are thought to be responsible for the plant's antioxidant and antimicrobial properties, making it a therapeutically important plant with the potential to be used as a drug as an antioxidant or against microbial diseases.
Mapping the Restoration of Degraded Peatland as a Field of Research Area: A Scientometric Review
Authors: Apori Samuel Obeng
Published: July 2022

Degraded peatland reduced many ecosystem services such as water quality and quantity, biodiversity, carbon storage, climate regulations and other cultural benefits. Therefore, several initiatives for the restoration of degraded peatland (RDP) have been attempted to restore the ecosystem processes, productivity and services of the degraded peatland to its original natural condition. Notwithstanding the popularity of RDP research among researchers and industry practitioners, a quantitative technique to map a comprehensive survey of the intellectual core and the general body landscape of knowledge on RDP research does not exist. In this study, a scientometric analysis was employed to analyze 522 documents using VOSviewer and CiteSpace. The Web of Science database was used to retrieve bibliographic records using the advanced search “TS (topic) =(‘drained peatland restoration’ OR ‘drained bog restoration’ OR ‘drained mire restoration’ OR degraded peatland restoration’ OR ‘degraded bog restoration’ OR ‘drained peatland reclamation’ OR ‘drained bog restoration’ OR ‘degraded peatland reclamation’ OR ‘degraded bog reclamation’ OR ‘drained mire restoration’ OR ‘degraded mire reclamation’ OR ‘degraded fen restoration’ OR ‘drained fen reclamation’). The outcome sought to provide relevant information in RDP research such as (i) publication trends (ii) research outlets (iii) most influential keywords (iv) most influential institutions and authors (v) top influential countries active in RDP research. In addition, four clusters were identified for ascertaining the central theme of RDP research in which cluster one is linked to the central research theme-“impact of drainage on peatland ecosystem services; cluster two focused on the impact of peatland restoration on greenhouse gas emissions; cluster three is associated with peatland restoration and biogeochemical properties and cluster four is related to peatland restoration and species richness. A new research hotspot such as soil respiration was identified via the keywords with the strongest citation bursts. This study will provide the various stakeholders such as industry, journal editors, policymakers and researchers instinctive understanding of the research status and the development frontier of RDP research
Atoms in Gaseous and Solid States and their Energy and Force Relationships under Transitional Behaviors
Authors: Ali Mubarak
Published: July 2022

By recalling the conventional studies of atoms, it is possible to discover new insights tackling the present and future challenges. Atoms of different elements form by electrons and energy knots. Atoms in elements recognize based on their electrons. The intercrossing of the photons having fixed lengths and numbers construct the lattice of an atom. The lengths and numbers of the intercrossed photons depend on the filled and unfilled states an atom possesses for its element. The intercrossing overt photons in a gaseous atom lattice are different than in the solid atom lattice. Except for the hydrogen atom, the atoms possess the same valency as specified. In the hydrogen atom, two energy knots occupy two electrons. In the helium atom, four energy knots occupy four electrons. A helium atom forms a zeroth ring in atoms of all higher-order elements. The study of protons and neutrons is no longer significant. Electrons of a gaseous atom deal with the minimum required potential energy, whereas the maximum is in a solid atom. Electrons in a gaseous atom experience the maximum required levitational force along the north pole. However, electrons experience the maximum required gravitational force along the south pole in a solid atom. In the transition state, electrons undertake infinitesimal displacements by remaining within the occupied energy knots, but they study a different nature of orientation for a gaseous atom and solid atom. These sorts of investigations study the atoms differently than the previous ones.
Karadere Deresi’nin (Araklı-Trabzon) İçme ve Sulama Suyu Amaçlı Kullanım Uygunluğunun İncelenmesi
Authors: FIRAT ERSOY Arzu , HATİPOĞLU TEMİZEL Esra
Published: July 2022

Bu çalışmada Karadere Deresi’nin su kalitesi özellikleri belirlenmiş, bu amaçla yüzey suyu örneklemesi yapılarak fiziksel parametreler, majör anyon-katyon ve iz element içerikleri belirlenmiştir. Hidrokimyasal özelliklerin belirlenmesi amacıyla yüzey suyu örneklemeleri Ekim-2020 ve Nisan-2021 olmak üzere iki dönemde gerçekleştirilmiştir. Su örneklerine ait fiziksel özellikler, majör anyon ve katyon analiz sonuçları Dünya Sağlık Örgütü WHO, TS266 (İnsani Tüketim Amaçlı Sular Hakkında Yönetmelik) ve Su Kirliliği Kontrolü Yönetmeliklerine göre değerlendirilmiştir. Karadere yüzey suyunda su tipleri Ca-HCO3 ve Ca-Na-HCO3 olarak belirlenmiştir. Karadere yüzey suyunun bu parametreler açısından WHO ve TS266 İnsani Tüketim Amaçlı Sular Hakkında yönetmeliğe göre içme suyuna uygun olduğu belirlenmiştir. Su Kirliliği Kontrolü Yönetmeliğine göre ise tüm parametrelerin I. ve II. Sınıf sular sınıfında bulunduğu tespit edilmiştir. Kirlilik açısından incelendiğinde ise NO2 içerikleri Karadere’nin IV. Sınıf su sınıfında olduğunu göstermektedir. İz element içerikleri açısından yağışlı döneme ait Al ve Fe değerlerinin TS266’da tanımlanan sınır değerlerin üzerinde olduğu belirlenmiştir. Karadere yüzey suyunun, sodyuma karşı hassas olan bitkiler dışındaki tüm bitkilerde ve orta derecede tuza ihtiyacı olan bitkilerde tarımsal faaliyetlerde kullanılabileceği ortaya konmuştur.
EVALUATION OF COVID-19 PNEUMONIA BY CONVENTIONAL RADIOGRAPHYAT AGMC & GBP HOSPITAL
Authors:   Post- Graduate Trainee Department of Radiodiagnosis, AGMC & GBP Hospital., Rani Ghosh Susmita , Dasar Ramachandra ,   Post- Graduate Trainee Department of Radiodiagnosis, AGMC & GBP Hospital., Shil Bibhas ,   Post- Graduate Trainee Department of Internal Mdicine, , AGMC & GBP Hospital., De Asim ,   HOD, Professor Department of Radiodiagnosis, AGMC & GBP Hospital.
Published: July 2022

Background: After its origin in Wuhan, China, coronavirus related respiratory illness spread across the globe, being declared as a pandemic by WHO on March 13,2020. Because it is acquired via respiratory droplets, community spread is responsible for the recent global crisis. Coronavirus related respiratory illness usually manifests clinically as pneumonia with predominant imaging findings of an atypical or organizing pneumonia. Chest radiographs are usually of limited value in the diagnosis of early stage specially in mild disease course however , the CT findings may be present early even before the onset of the symptoms. Chest radiographs is very helpful in the intermediate to advanced stages of COVID-19 with features of acute respiratory distress syndrome (ARDS) as well as the follow-up. Objective:ToevaluatetheCOVID-19pneumoniabyChestX-ray findings. ToassesstheseverityofCOVID-19pneumoniausingchest x-rayscoringsystem. Materials and method: An observational longituidinal study was carried over 8 weeks at an Radiodiagnosis department of a tertiary care Hospital in North- Eastern India. Around 60 cases of COVID-19 RT-PCR positive patients evaluated by chest x-ray and different radiographic features were studied. The data were analyzed accordingly by descriptive statistics for the result. Result: The study population was predominantly male (69%), with mean age of 49.5Â± 9.5 years. Among RTPCR positive patients 71.43% had abnormal baseline chest X-rays among abnormal CXRs 57.5% shows groundglass opacity, 30% shows consolidation and 7.5% shows pleural effusion. Conclusion:Radiographic findings are very good predictor for assessing the course of COVID-19 diseases and it could be used as long â€“term consequences monitoring and assessing the severity scoring.
LAW, CONTESTED SPACE AND THE POLITICAL ECONOMY OF VILLAGE-OWNED STATE ENTERPRISES INSTITUTIONALISM IN INDONESIA
Authors:   Lecturer, Faculty of Law, JenderalSoedirman University, Indonesia., Afwa Ulil
Published: July 2022

Village-Owned State Enterprises is a vital institution to create a dialogue in the village as a reflection of sovereignty from the village community to their economic development. In the ideal management, to increase participation and create economic sovereignty of the Village-Owned State Enterprises, it should be freed from the intervention of local elite capture. The institutionalism process of village-level economic institutions through Village-Owned State Enterprises is a form of creating a local democratic economy in the village. This institutional reform is made to create a market-friendly institution within society that will create institutional structures which provide a more secure environment to community participation in society to evolve and improve capacity and capability as a reflection of the democratic economy. This paper will address 3 things to analyze: 1)Analyze the nature of the prismatic community in Indonesia in responding to the policy from the government regarding the making of Village-Owned State Enterprises 2) Examines the way in which political factors have shaped the process of Village-Owned State Enterprises in Indonesia 3) Presents the conclusion to the chapter. This research is kind of a qualitative method. The research sampling that is used is purposive sampling with the informants. While the data analysis method used is descriptive.
DRUG UTILIZATION PATTERNS USING WHO CORE PRESCRIBING INDICATORS IN DIFFERENT OUT PATIENT DEPARTMENTS AT SECONDARY CARE HOSPITAL, KARIMNAGAR
Authors:   Department of Pharmaceutics, Chaitanya College of Pharmacy Education & Research, Hanamkonda-506001., Saboor Shaiqha , Fatima Zareen ,   Department of Pharmaceutical Analysis, Tirumala College of Pharmacy-Nizamabad-503001., Masood Hanna ,   Department of Pharmacology, Vaageswari College of Pharmacy, Karimnagar-505001., Ahad Hussain Syed ,   Department of Pharmacology, Vaageswari College of Pharmacy, Karimnagar-505001.
Published: July 2022

Aim:The aim of this study is to assess the prescribing patterns of medicines, apply the World Health Organization (WHO) core indicators and to assess the appropriateness of prescribed medicines in a pediatric unit. Materials and Methods:A prospective observational drug utilization study of outpatients was carried out in secondary care hospital for a period of 2 months. Patients who attended different units were included in the study and patients who were not willing to participate in the study were excluded and the data collected from the hospital were analyzed. Results:Out of 150 patients, the average number of drugs per patient was 4.56. The percentage of drugs prescribed with the generic name was found to be 19.16%. Among 150 prescriptions 49.78% of the drugs were prescribed from essential drug list. Among the antibiotics 33.33% were prescribed, cephalosporin group were the most commonly prescribed followed by amino glycoside and penicillin. Nearly, 21.80% of the medicines were given as intravenous and the prescriptions without drugs were 1.43%. Only 75.6% of patients have knowledge about their dosage schedule and almost all the prescriptions were appropriate. Conclusion:The assessment of WHO core indicators helped to improvise the prescribing pattern, identify significant problems involved in the knowledge gap of patients or caretakers understanding of instructions provided by consultants and even to minimize the cost burden on patient.
CLINICAL RELEVANCE AND ROLE OF FUNGAL AND BACTERIAL INFECTIONS ON HUMANS
Authors:   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Prasanna Sanikommu Lakshmi , Sree Kommineni Monyya ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Yerramreddy Manasa ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Venkata Lakshmi Lingam Sai ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Harsha Kathi Sri ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Yelem Bharathi ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Radha Sajja Vasavi ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Singh Ranwas Reethika ,   Department of Bioengineering and Technology, Technical Research Centre, North East Research Enclave Campus, Guwahati, Assam, India.
Published: July 2022

The purpose of our study is to focus on the causes of infectious diseases and on the reactions of the host to the pathogens. Although the advent od antibiotics and vaccines has certainly taken the dread out of many infectious diseases, the treat of infection is still a fact of life. New pathogens are constantly being discovered, strains of old ones have developed resistance to antibiotics, making therapy more and more difficult, while incurable diseases like AIDS, rabies etc. are still with us. Infectious diseases have been known for thousands of years, although accurate information on their etiology has only been available for about a century. We focussed on the broad knowledge of the etiologic organisms causing disease and the pathogenetic mechanisms leading to clinically manifest infections into its users. This knowledge is needed for every individual and a prerequisite for the diagnosis, therapy and prevention of infectious diseases.
A STUDY EVALUATING THE EFFECT OF INVESTING MEDIUM ON THE TOOTH MOVEMENT DURING DENTURE PROCESSING A RESEARCH STUDY
Authors:   BDS, MDS in Prosthodontics, Government Dental College and Hospital, Srinagar., Altaf Tantray Ex Senior Resident Mohd , Mir PG Scholar Udfer ,   BDS, MDS in Prosthodontics, Government Dental College and Hospital, Srinagar.
Published: July 2022

The tooth movement occurs during denture processing. Understanding the tooth moving factors helps one to minimise the artificial tooth movements for harmonious occlusion. Purpose: this study was conducted to evaluate the effect investing mediums on the tooth movement during denture processing. Materials and methods: Thirty maxillary dentures made in heat cured acrylic resin were randomly grouped depending on the investing medium used- P-P-P group and P-S-P group. The transverse and anteroposterior distances were measured by digital calliper before and after denture processing. The magnitude of tooth movement was determined by difference between final and initial values. Results: the tooth movement was significantly higher in plaster-stone-plaster group than that of plaster-plaster-plaster group. Anteroposterior tooth movement was significantly higher than transverse tooth movement in both the groups.
Forecasting the net investment position based on conventional and ESG stock market indices: The case of Ukraine and Austria
Authors: Plastun Alex , Makarenko Inna , Salabura Daniel , Serpeninova Yulia , Situm Mario
Published: July 2022

This paper examines the relationship between traditional and ESG stock market indices and the net international investment position for the case of Austria and Ukraine. For these purposes, the following methods are used: variance analysis, ANOVA analysis, correlation analysis, VAR analysis, R/S analysis, and Granger causality test. According to the results, ESG indices are less volatile than conventional ones. Based on the correlation analysis, it is concluded that there is a significant direct connection between ESG indices and their traditional counterparts (0.98 for Austria and 0.68 for Ukraine). A substantial level of persistence in Austria’s investment position indicates the possibility of using autoregression models for forecasting. The results of the net investment position modelling for the case of Austria showed a statistically significant impact of stock market indices on the net investment position. But for the case of Ukraine, this impact is insignificant. This is indirect evidence in favor of poor performance of the Ukrainian stock market. Further development of Ukrainian stock market is required, because Austrian experience showed that stock market can be used as a transmission mechanism in boosting investment position both within conventional approach and ESG.
Acknowledgment Alex Plastun, Mario Situm, Inna Makarenko, and Yulia Serpeninova gratefully acknowledge support from Ministry of Education and Science of Ukraine (0122U002659).
Dynamic characteristic research on a simulated sugarcane field exciter for small sugarcane harvesters: simulations and experiments
Authors: Mo Hanning , Qiu Chen , Li Shangping , Ma Shaochun
Published: July 2022

The sugarcane harvester vibration has a bad effect on the sugarcane cutting quality. The effect of sugarcane field roughness on the sugarcane harvester vibration is much more significant than those of cutting forces and the engine. In order to simulate sugarcane field roughness, a simulated sugarcane field exciter (SSFE) was developed to actuate a self-developed sugarcane harvester experiment platform (SHEP). The dynamics and the mathematical models of the SHEP were established. Simulations of the mathematical model show these two models are reasonable. The dynamic characteristic experiment of the SSFE shows it matches characteristics of sugarcane field roughness, but great lateral oscillations existed when it worked. Then the SSFE II was developed. The dynamic characteristic experiment of the SSFE II shows it matches characteristics of sugarcane field roughness and improves the SSFE. The modal test of the SHEP was done to further study dynamic characteristics of the SSFE II. With the SSFE II, simulated experiments of sugarcane harvesters under complete vibration causing conditions can be done in labs instead of sugarcane fields to avoid the low efficiency, poor security and bad reliability during experiments in sugarcane fields.
The Association Between the Risk of Breast Cancer and Epigallocatechin-
3-Gallate Intake: A Literature Review of a Potential Chemopreventive
Agent
Authors: Athanasiou Efstratios , Verras Georgios-Ioannis , Papageorgiou Savvas , Kelesis Ioannis , Gatsis Athanasios , Karaoulani Christina , Stouras Ioannis , Kanatas Panagiotis , Saitani Elmina-Marina , Oikonomou Maria-Eleni , Vlassi Danae-Anastasia , Vasileiou Maria , Tsagkaris Christos , Alexiou Athanasios , Kamal Mohammad Amjad
Published: July 2022

According to the latest epidemiological data, breast cancer has recently been
the most frequently diagnosed malignancy. To date, a body of evidence has established
the involvement of multiple - and frequently interrelated - genetic and environmental factors
in the pathogenesis of the disease. Emerging research on cancer prevention has highlighted
the deterrence potential of interventions targeting environmental risk factors, particularly
diet. In this aspect, the current review reveals the latest scientific results regarding
epigallocatechin-3-gallate (EGCG) - a catechin most commonly found in green tea,
as a potential chemopreventive dietary agent against breast cancer. in vitro studies on
EGCG have demonstrated its effect on cell cycle progression and its potential to suppress
several intracellular signaling pathways involved in breast cancer pathogenesis. In addition,
EGCG possesses specific apoptosis-inducing characteristics that seem to enhance
its role as a regulator of cell survival. Preclinical data seem to support using EGCG as an
effective adjunct to EGFR-targeting treatments. The authors’ appraisal of the literature
suggests that although preclinical evidence has documented the anticarcinogenic features
of EGCG, limited large-scale epidemiological studies are investigating the consumption
of EGCG - containing nutrients in the prevention and management of breast cancer risk.
This literature review aims to liaise between preclinical and epidemiological research,
surveying the existing evidence and unraveling relevant knowledge gaps.
Withdrawn: Specialized Pro-resolving Lipid Mediators: Endogenous Regulation of Vascular
Inflammation and Remodeling
Authors: Zhao Ansha , Liu Li , Qian Liubin , Wang Jingyue
Published: July 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
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Nano-vaccination Strategies: Applications and Challenges for Intranasal Immunization
Authors: Pandya Tosha , Joshi Prachi , Pathak Rudree , Shah Shreeraj
Published: July 2022

The nasal route, a subgroup of mucosal delivery systems, constitutes a lucrative and encouraging substitute for administering drugs and vaccines. Over the years, a lot of research has been done in this area, and scientists have successfully explored this pathway using novel formulations to combat several infections. This review article aims to address the pathways of mucosal immunization, the dominance of the nasal route over other mucosal routes for immunization, and the mechanism of generation of immunogenic response via nasal route and nanotechnology-based approaches for intranasal vaccination. The immunotherapeutic and vaccinations for intranasal administration available in the market are also discussed, along with a brief overview of the products in the pipeline. It can also be assumed that such an approach can prove to be favorable in designing vaccinations for the current uncertain times. In spite of some dubious views on this.
Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification,
and Structure-Activity Relationships
Authors: Li Shaochen , Lv Min , Xu Hui
Published: July 2022

Natural products are an invaluable source for the discovery of drug and pesticide candidates.
Piperine, a simple and pungent alkaloid, is isolated from several plants of Piperaceae.
Piperine and its derivatives displayed a wide range of biological properties, such as antitumor activity,
anti-inflammatory activity, antioxidant activity, neuroprotective activity, insecticidal activity,
etc. In recent years, lots of works focused on the biological activities, mechanisms of action,
total synthesis, and structural modifications of piperine and its derivatives have been conducted.
To the best of our knowledge, however, few review articles related to the biological activities,
mechanisms of action, total synthesis, and structural modifications of piperine and its derivatives
have been reported to date. Therefore, this review summarizes the research advances (from 2014
to 2020) of piperine and its derivatives regarding bioactivity, mechanisms of action, total synthesis,
and structural modifications. Meanwhile, the structure-activity relationships of piperine and
its derivatives are also discussed.
Does Weekends Effect Exist in Asia? Analysis of Endovascular Thrombectomy
for Acute Ischemic Stroke in A Medical Center
Authors: Wang Charles C.N. , Lin Chia-Wei , Huang Hung-Yu , Guo Jeng-Hung , Chen Wei-Laing , Shih Hong-Mo , Chu Hsueh-Ting , Hsu Tai-Yi
Published: July 2022

Background:

Discussing the quality measurements based on interrupted time series in
ischemic stroke, delays are often attributed to weekends effect. This study compared the metrics and
outcomes of emergent endovascular thrombectomy (EST) during working hours versus non-working
hours in the emergency department of an Asian medical center.

Methods:

A total of 297 patients who underwent EST between January 2015 and December 2018
were retrospectively included, with 52.5% of patients presenting during working hours and 47.5%
presenting during nights, weekends, or holidays.

Results:

Patients with diabetes were more in non-working hours than in working hours (53.9% vs.
41.0%; p=0.026). It took longer during nonworking hours than working hours in door-to -image
times (13 min vs. 12 min; p=0.04) and door-to-groin puncture times (median: 112 min vs. 104 min;
p=0.042). Significant statistical differences were not observed between the two groups in neurological
outcomes, including successful reperfusion and complications such as intracranial hemorrhage
and mortality. However, the change in National Institute of Health Stroke Scale (NIHSS) scores in
24 hours was better in the working-hour group than in the nonworking-hour group (4 vs. 2;
p=0.058).

Conclusions:

This study revealed that nonworking-hour effects truly exist in patients who received
EST. Although delays in door-to-groin puncture times were noticed during nonworking hours, significant
differences in neurological functions and mortality were not observed between working and
non-working hours. Nevertheless, methods to improve the process during non-working hours should
be explored in the future.
Characteristics of Amphetamine Psychosis with Respect to the Length of
Drug Exposure
Authors: Sokolova Iryna , Babina Anastasia , Vysotskyi Mykhailo
Published: July 2022

Background:

Over the past decade, the number of individuals requiring medical care for
amphetamine-related psychosis has increased.

Objective:

This study aims to examine the psychological characteristics of amphetamine psychosis in
drug-addicted patients depending on the length of drug exposure and compared to patients diagnosed
with paranoid schizophrenia.

Method:

The study was carried out in psychiatric clinic No. 1 in Kyiv (Ukraine) in 2019, involving
107 patients. Of all the participants, 50 were included in Group 1 (methamphetamine psychosis) and
57 - in Group 2 (paranoid schizophrenia). All patients were treated with medication to relieve exacerbating
symptoms. They underwent extensive testing to determine the impairment severity of cognitive
function, attention, and task performance during remission.

Results:

In Group 1, the timing of onset for paranoid symptoms depends on the length of amphetamine
exposure (Spearman correlation coefficient = 0.89). The efficacy and dynamics of drug treatment
in Group 2 were similar to patients in Group 1. However, the effect of reduction in Group 2 was
achieved only in 4 months. Delusions, emotional disturbances, hallucinations in patients of Group 1
occurred 2.3 times more frequently than in Group 2 (p ≤ 0.05). The patients of Group 1 are characterized
by the presence of disorders related to the affective and behavioral components.

Conclusion:

All reported exacerbations are related to amphetamine use. Patients in Group 1 learned a
smaller number of words compared to those in Group 2. Besides, a large number of errors and difficulties
with shifting focus were recorded.
Probing the Ubiquitination-Mediated Function of Epithelial Sodium
Channel in A549 Cells
Authors: Oz Murat , Shabbir Waheed , Susan Yang Keun-Hang , Dogar Afzal M. , Isaev Dmytro
Published: July 2022

Background:

The activity of the amiloride-sensitive epithelial sodium channel
(ENaC) in the tight epithelia of the lung is regulated by proteolytic activation and ubiquitination.
Pathophysiology of lung diseases is directly related to changes in one or both of these mechanisms.

Methods:

In this study, we investigated the impact of ubiquitination and cathepsin-mediated proteolytic
activation mechanisms on the functional regulation of ENaC in lung cancer A549 cells
using the patch-clamp technique.

Results:

Our findings suggest that inhibiting the proteasome (polyubiquitination) with MG132
improves ENaC activity, whereas altering the pH of the lysosome (monoubiquitination inhibition)
with NH4Cl has no effect on ENaC activity. In A549 cells, inhibition of cathepsin B
(CSTB) decreased the ENaC current, open probabilities (NPo and Po), and the number of active
channels.

Conclusion:

These findings delineate novel modes of ENaC degradation and proteolytic activation
of functional channels in A549 cells. Our findings indicate that both proteolytic activation
and ubiquitination of ENaC significantly affect channel function and add new insights into the
endogenous ENaC processing which might help to further understand the pathophysiology of the
lung disease.
Intelligent Load Balancing Algorithms for Internet of Things - A Review
Authors: Gul Safia , Malik Bilal Ahmad , Banday Mohamad Tariq
Published: July 2022

The Internet of Things has witnessed an upsurge in the number of sensors communicating
with each other over the Internet, and this number, currently in billions, is increasing at an expeditious
pace. However, this augmentation in the number of interlaced devices can lead to profusion and jamming of the network, thereby degrading energy, latency, and throughput. Load balancing of the network is one of the techniques which could alleviate this issue. This paper reviews the methods that
have been employed for load balancing of the Internet of Things, thereby serving the research community two-fold. Firstly, it gives a comprehensive introduction to the classification of load balancing
algorithms. Secondly, it offers researchers the prospect of developing intelligent novel algorithms
catering to the load balancing predicament.
3D-Printed Microfluidics Potential in Combating Future and Current
Pandemics (COVID-19)
Authors: Eassa Heba A. , Helal Nada A. , Amer Ahmed M. , Fouad Aliaa , Bedair Asser F. , Nagib Reem , Mansoor Ihab , Hawash Motaz , Abdul-Latif Maha , Mohammed Kamilia H.A. , Helal Mohamed A. , Nounou Mohamed Ismail
Published: July 2022

Coronavirus disease (COVID-19) emerged in China in December 2019. In March 2020, the
WHO declared it a pandemic leading to worldwide lockdowns and travel restrictions. By May, it infected
4,789,205 and killed 318,789 people. This led to severe shortages in the medical sector besides
devastating socio-economic effects. Many technologies such as artificial intelligence (AI), virtual reality
(VR), microfluidics, 3D printing, and 3D scanning can step into contain the virus and hinder its extensive
spread. This article aims to explore the potentials of 3D printing and microfluidic in accelerating
the diagnosis and monitoring of the disease and fulfilling the shortages of personal protective
equipment (PPE) and medical equipment. It highlights the main applications of 3D printers and microfluidics
in providing PPE (masks, respirators, face shields, goggles, and isolation chambers/hoods),
supportive care (respiratory equipment) and diagnostic supplies (sampling swabs & lab-on-chip) to
ease the COVID-19 pressures. Also, the cost of such technology and regulation considerations are addressed.
We conclude that 3D printing provided reusable and low-cost solutions to mitigate the shortages.
However, safety, sterility, and compatibility with environmental protection standards need to be
guaranteed through standardization and assessment by regulatory bodies. Finally, lessons learned from
this pandemic can also help the world prepare for upcoming outbreaks.
Diabetes Self-management Apps: Systematic Review of Adoption Determinants and Future Research Agenda
Authors: Alaslawi Hessah , Berrou Ilhem , Al Hamid Abdullah , Alhuwail Dari , Aslanpour Zoe
Published: July 2022

Background

Most diabetes management involves self-management. Effective self-management of the condition improves diabetes control, reduces the risk of complications, and improves patient outcomes. Mobile apps for diabetes self-management (DSM) can enhance patients’ self-management activities. However, they are only effective if clinicians recommend them, and patients use them.

Objective

This study aimed to explore the determinants of DSM apps’ use by patients and their recommendations by health care professionals (HCPs). It also outlines the future research agenda for using DSM apps in diabetes care.

Methods

We systematically reviewed the factors affecting the adoption of DSM apps by both patients and HCPs. Searches were performed using PubMed, Scopus, CINAHL, Cochrane Central, ACM, and Xplore digital libraries for articles published from 2008 to 2020. The search terms were diabetes, mobile apps, and self-management. Relevant data were extracted from the included studies and analyzed using a thematic synthesis approach.

Results

A total of 28 studies met the inclusion criteria. We identified a range of determinants related to patients’ and HCPs’ characteristics, experiences, and preferences. Young female patients were more likely to adopt DSM apps. Patients’ perceptions of the benefits of apps, ease of use, and recommendations by patients and other HCPs strongly affect their intention to use DSM apps. HCPs are less likely to recommend these apps if they do not perceive their benefits and may not recommend their use if they are unaware of their existence or credibility. Young and technology-savvy HCPs were more likely to recommend DSM apps.

Conclusions

Despite the potential of DSM apps to improve patients’ self-care activities and diabetes outcomes, HCPs and patients remain hesitant to use them. However, the COVID-19 pandemic may hasten the integration of technology into diabetes care. The use of DSM apps may become a part of the new normal.
Assessing Telemedicine Efficiency in Follow-up Care With Video Consultations for Patients in Orthopedic and Trauma Surgery in Germany: Randomized Controlled Trial
Authors: Muschol Jennifer , Heinrich Martin , Heiss Christian , Knapp Gero , Repp Holger , Schneider Henning , Thormann Ulrich , Uhlar Johanna , Unzeitig Kai , Gissel Christian
Published: July 2022

Background

Telemedicine can help mitigate important health care challenges, such as demographic changes and the current COVID-19 pandemic, in high-income countries such as Germany. It gives physicians and patients the opportunity to interact via video consultations, regardless of their location, thus offering cost and time savings for both sides.

Objective

We aimed to investigate whether telemedicine can be implemented efficiently in the follow-up care for patients in orthopedic and trauma surgery, with respect to patient satisfaction, physician satisfaction, and quality of care.

Methods

We conducted a prospective randomized controlled trial in a German university hospital and enrolled 60 patients with different knee and shoulder conditions. For follow-up appointments, patients received either an in-person consultation in the clinic (control group) or a video consultation with their physician (telemedicine group). Patients’ and physicians’ subsequent evaluations of these follow-up appointments were collected and assessed using separate questionnaires.

Results

On the basis of data from 52 consultations after 8 withdrawals, it was found that patients were slightly more satisfied with video consultations (mean 1.58, SD 0.643) than with in-clinic consultations (mean 1.64, SD 0.569), although the difference was not statistically significant (P=.69). After excluding video consultations marred by technical problems, no significant difference was found in physician satisfaction between the groups (mean 1.47, SD 0.516 vs mean 1.32, SD 0.557; P=.31). Further analysis indicated that telemedicine can be applied to broader groups of patients and that patients who have prior experience with telemedicine are more willing to use telemedicine for follow-up care.

Conclusions

Telemedicine can be an alternative and efficient form of follow-up care for patients in orthopedic and trauma surgery in Germany, and it has no significant disadvantages compared with in-person consultations in the clinic.

Trial Registration

German Clinical Trials Register DRKS00023445; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00023445