bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression of the NUP153 and YWHAB genes from their canonical promoters and alternative promoters of the LINE-1 retrotransposon in the placenta of the first trimester of pregnancy
Authors: Demeneva V. V. , Tolmacheva E. N. , Nikitina T. V. , Sazhenova E. A. , Yuriev S. Yu. , Makhmutkhodzhaev A. Sh. , Zuev A. S. , Filatova S. A. , Dmitriev A. E. , Darkova Ya. A. , Nazarenko L. P. , Lebedev I. N. , Vasilyev S. A.
Published: March 2023

The placenta has a unique hypomethylated genome. Due to this feature of the placenta, there is a potential possibility of using regulatory elements derived from retroviruses and retrotransposons, which are suppressed by DNA methylation in the adult body. In addition, there is an abnormal increase in the level of methylation of the LINE-1 retrotransposon in the chorionic trophoblast in spontaneous abortions with both normal karyotype and aneuploidy on different chromosomes, which may be associated with impaired gene transcription using LINE-1 regulatory elements. To date, 988 genes that can be expressed from alternative LINE-1 promoters have been identified. Using the STRING tool, genes (NUP153 and YWHAB) were selected, the products of which have significant functional relationships with proteins highly expressed in the placenta and involved in trophoblast differentiation. This study aimed to analyze the expression of the NUP153 and YWHAB genes, highly active in the placenta, from canonical and alternative LINE-1 promoters in the germinal part of the placenta of spontaneous and induced abortions. Gene expression analysis was performed using real-time PCR in chorionic villi and extraembryonic mesoderm of induced abortions (n = 10), adult lymphocytes (n = 10), spontaneous abortions with normal karyotype (n = 10), and with the most frequent aneuploidies in the first trimester of pregnancy (trisomy 16 (n = 8) and monosomy X (n = 6)). The LINE-1 methylation index was assessed in the chorionic villi of spontaneous abortions using targeted bisulfite massive parallel sequencing. The level of expression of both genes from canonical promoters was higher in blood lymphocytes than in placental tissues (p < 0.05). However, the expression level of the NUP153 gene from the alternative LINE-1 promoter was 17 times higher in chorionic villi and 23 times higher in extraembryonic mesoderm than in lymphocytes (p < 0.05). The expression level of NUP153 and YWHAB from canonical promoters was higher in the group of spontaneous abortions with monosomy X compared to all other groups (p < 0.05). The LINE-1 methylation index negatively correlated with the level of gene expression from both canonical (NUP153 – R = –0.59, YWHAB – R = –0.52, p < 0.05) and alternative LINE-1 promoters (NUP153 – R = –0.46, YWHAB – R = –0.66, p < 0.05). Thus, the observed increase in the LINE-1 methylation index in the placenta of spontaneous abortions is associated with the level of expression of the NUP153 and YWHAB genes not only from alternative but also from canonical promoters, which can subsequently lead to negative consequences for normal embryogenesis.
Potential Dermatological Effects of Climate Change in Africa
Authors: Pillay L , Sema-Ramashala AR , Jessop S , Raboobee N , Lehloenya R , Moosa L , Mosam A
Published: March 2023

Climate change represents a major existential threat facing the global community, and it has already begun to affect human health in a multitude of ways. This article highlights and discusses the implications that climate change has already had and is expected to have for dermatologists.

A number of conditions are affected by climate changes. The distribution and frequencies of infections have altered due to changes in the causative organisms. Inflammatory conditions like atopic dermatitis have been exacerbated and the raised temperatures will also worsen the effects of ultraviolet radiation. Extreme weather events that result from climate change are followed by an array of dermatologic conditions that may be unusual for the given location. Dermatologists should be prepared to manage these potentially unfamiliar dermatologic consequences of climate change.
Effect of Crop Geometry and Nutrient Management Approaches on Yield and Quality of Transplanted Finger Millet
Authors: Aliveni A. , Venkateswarlu B. , Rekha M. Sree , Prasad P.R.K. , Jayalalitha K.
Published: March 2023

Background: An ideal crop geometry is essential for obtaining optimum plant stand in the field as the yield of a crop depends on the final plant density with effective utilization of growth resources. Conjunctive use of chemical fertilizers and organic manures is important to maintain and sustain soil fertility and crop productivity. Nutrient Management system is gaining importance among the farmers and it is advisable to optimize the use of inorganic fertilizers along with organic manures for getting high yields of better quality besides keeping the production cost at sustainable level. The current field study was aimed to evaluate the impact of various crop geometries and nutrient management treatments on yield and quality of transplanted finger millet. Methods: A Field experiment was conducted at Agricultural college farm, Bapatla during the kharif seasons of 2018 and 2019 and the experimental design was split plot with three replications. The main-plot factor comprised of three crop geometries with different age of seedlings and seven nutrient management practices in subplots. Result: The experimental results indicated that significantly higher grain and straw yields with good quality grain of finger millet were recorded in the spacing of 30 × 10 cm fb 30 × 30 cm spacing and among the nutrient management approaches application of FYM @ 10 tonnes ha-1 + 125% RDF along with wooden log treatment (S6) recorded the highest yield and however was statistically comparable with 125% of RDF + FYM (S5).
PERLINDUNGAN HUKUM TERHADAP PENGUPAHAN MENURUT UNDANG-UNDANG NOMOR 13 TAHUN 2003 TENTANG KETENAGAKERJAAN PADA PT. TANDAN ABADI MANDIRI KABUPATEN SAROLANGUN JAMBI
Authors: Salsabila Adinda tahlia , Antasari RR rina , Marzuki Marzuki
Published: March 2023

ABSTRAK
 
Upah atau gaji adalah hak pemenuhan ekonomi bagi pekerja yang menjadi kewajiban dan tidak boleh diabaikan oleh para pihak yang mempekerjakan. Islam menekankan perlunya keadilan dalam segala hal, salah satunya mengenai pemberian gaji/upah kepada pekerja. Seperti yang terjadi di PT. Tandan Abadi Mandiri Kabupaten Sarolangun Jambi. Dimana upah yang diberikan sesekali mengalami keterlambatan hingga sampai tidak dibayarkan. Pokok kajian dalam penelitian ini adalah bagaimana sistem pembayaran upah tenaga kerja di PT. Tandan Abadi Mandiri Kabupaten Sarolangun Jambi menurut Undang-Undang Nomor 13 Tahun 2003 tentang Ketenagakerjaan dan bagaimana Tinjauan Hukum Ekonomi Syariah terhadap pengupahan di PT. Tandan Abadi Mandiri Kabupaten Sarolangun Jambi. Tujuan penelitian ini adalah untuk mengetahui bagaimana pembayaran upah di PT. Tandan Abadi Mandiri Kabupaten Sarolangun Jambi, dan untuk mengetahui bagaimana Tinjauan Hukum Ekonomi Syariah terhadap pembayaran upah tenaga kerja di PT. Tandan Abadi Mandiri Kabupaten Sarolangun Jambi. Metode penelitian yang digunakan dalam penelitian ini adalah jenis penelitian lapangan (field research) yaitu penelitian yang sumber datanya diambil secara langsung di lapangan dengan cara mengamati secara langsung kejadian yang terjadi di lokasi penelitian (observasi), wawancara langsung dengan responden, dan dokumentasi. Analisis data dalam penelitian ini adalah dengan metode Deskriptif Kualitatif dan disimpulkan secara dedukatif. Kesimpulan dari kajian ini adalah pembayaran upah tenaga kerja di PT. Tandan Abadi Mandiri belum sesuai dengan Pasal 1 ayat 30 Undang-Undang Nomor 13 Tahun 2003 Tentang Ketenagakerjaan karena pembayaran upahnya sering terlambat hingga sampai tidak dibayarkan, sehingga berpengaruh terhadap kesejahteraan pekerja. Sedangkan menurut pandangan Hukum Ekonomi Syariah pembayaran upah pekerja di PT. Tandan Abadi Mandiri Kabupaten Sarolangun Jambi telah sesuai dengan hukum Islam, karena dilihat dari bentuk, objek, dan akadnya yang tidak menyalahi aturan dalam hukum Islam, namun pada syarat ijarah adanya kerelaan tanpa keterpaksaan belum terpenuhi.
 
Kata Kunci: Perlindungan Hukum, Pengupahan, Ketenagakerjaan.
Tinjauan Hukum Ekonomi Syariah Terhadap Praktik Discount Dalam Member Card Pada Kasus Toko Rabbani Plaju Palembang
Authors: Nis Chairun , Armasito Armasito
Published: March 2023

Manusia sebagai mahluk sosial tidak bisa lepas dari kehidupan perekonomian yaitu jual beli. Aktivitas jual beli dengan berbagai macam bentuk untuk membangun usaha yang memberikan keuntungan. Salah satunya praktik jual beli menggunakan member card yang bertujuan untuk mendapatkan discount. Praktik discount dalam member card yang terjadi di Toko Rabbani Plaju Palembang dalam penggunaan member cardnya untuk pendaftaran dikenakan biaya sebesar Rp.50.000 perlu diketahui bahwa dalam penggunaan member card tersebut hanya berlaku jangka waktu 1 tahun setelah itu adanya biaya perpanjangan member card  tersebut sebesar Rp.25.000. Sistem praktik discount dalam member card yang terjadi di Toko Rabbani Plaju Palembang itu dinilai bertentangan dengan nilai syari’ah, asumsi atas hal tersebut disampaikan oleh Dr. Oni Sahroni yang merupakan Dewan Syariah Nasional Majelis Ulama Indonesia bahwa kartu discount dengan iuran berkala dan biaya keanggotaan itu tidak diperbolehkan dalam Islam karna ada unsur gharar. Adapun rumusan masalah dalam skripsi ini yaitu :1) Bagaimana praktik discount dalam member card di Toko Rabbani Plaju Palembang? 2) Bagaimana tinjauan hukum ekonomi syariah terhadap praktik discountdalam member card di Toko Rabbani Plaju Palembang?. Metode penelitian ini adalah field research dan metode jenis data yang digunakan yaitu kualitatif. Populasi dalam penelitian ini yaitu pengguna member card di Toko Rabbani Plaju Palembang dan sample yang digunakan berjumlah 8 orang. Teknik pengumpulan data dilakukan dengan studi lapangan dan studi kepustakaan. Data yang terkumpul kemudian dianalisis secara deskriptif kualitatif. Hasil penelitian ini adalah bahwa praktik discount dalam member card di Toko Rabbani Plaju apabila sudah mendaftar maka akan mendapatkan discount 10 % sampai15%,discount berlaku untuk semua barang tanpa adanya minimal pembelian dalam seminggu,Toko Rabbani Plaju Palembang ini juga pada saat akhir tahun selalu ada program promo discount 50 % tetapi hanya untuk yang ada member card saja.  Menurut hukum ekonomi syariah bahwa discount dalam member card itu diperbolehkan. Dalam transaksi jual beli yang ditinjau dari hukum ekonomi syariah member card Rabbani  ini jika sudah melakukan pendaftaran dengan berbayar atau gratis tentunya calon member sudah mengetahui akan mendapatkan discount didalam member card dengan cara harus memenuhi semua persyaratannya. Tentunya kedua belah pihak sudah saling tahu serta ridho apapun yang menjadi persyaratan dalam transaksi tersebut. Akan hal itu keduabelah pihak sama-sama mendapatkan keuntungan dan didalamnya tidak ada unsur penipuan karena biaya pembayaran pendaftaran atau perpanjangan member card tersebut termasuk ke dalam upah kerja.

 

Kata Kunci : Discount, Member Card, Jual beli
LARANGAN PELAKSANAAN ADAT MANDI KASAI PADA RITUAL PERKAWINAN MASYARAKAT LUBUKLINGGAU DI MASA PANDEMI COVID 19
Authors: Arafah Ricca Alfiatul , Tsani Wifa Lutfiani
Published: March 2023

Sejak tahun 2020 Indonesia dilanda pandemi covid-19, pemerintah melalui Kementrian Agama (Kemenag) mengeluarkan Surat Edaran Nomor: P-004/DJ.III/Hk.00.7/04/2020 Tentang Pengendalian Pelaksanaan Nikah di Masa Darurat Bencana Wabah Penyakit Akibat Covid-19. Lalu bagaimana dengan ritual adat Mandi Kasai yang harus ditiadakan pada masa pandemi COVID-19 ini. Maka tulisan ini menganalisis mengenai larangan ritual adat Mandi Kasai pada upacara perkawinan masyarakat Lubuklinggau pada saat pandemi COVID-19. Hasil dari penelitian ini, perkawinan tetap  dilaksanakan hanya dengan akad nikah tanpa adanya ritual adat. Tujuan diberlakukan larangan ini yaitu menunda perkawinan adat pada masa pandemi COVID-19 adalah perbuatan yang mulia karena menyelamatkan banyak jiwa. Segala hal yang lebih banyak menimbulkan mudharat harus dijauhi.
HAK ASUH ANAK (HADANAH) BAGI IBU PASCA PERCERAIAN KEDUA MENURUT IMAM MALIK
Authors: Fitriyana Rosa , Aulia Mohamad Faisal
Published: March 2023

Penelitian ini dilatar belakangi oleh perbedaan pendapat antara Imam Malik dengan jumhur ulama tentang hak asuh anak bagi ibu pasca perceraian dengan suami kedua. Jenis penelitian ini adalah penelitian kepustakaan (library research) yang bersifat deskriptif analitik, dengan bahan data primernya adalah kitab al-Mudawwanah al-Kubra. Hasil penelitian pada penulisan ini menunjukkan bahwa Imam Malik dalam kitabnya al-Mudawwanah al-Kubra menyebutkan bahwa hak hadhanah tidak akan dikembalikan kepada ibu walaupun ia sudah bercerai dengan suami kedua. Berbeda dengan pendapat jumhur ulama (Abu Hanifah, Imam Syafi’i dan Imam Ahmad) bahwa apabila ibu telah bercerai dengan suami kedua maka hak hadhanah anak dikembalikan kepada ibu. Dari analisis diatas dapat disimpulkan bahwa dalam permasalahan hak hadhanah ini Imam Malik menafsirkan hadis secara zahirnya saja, tanpa melihat sebab-sebab yang menghalangi. Oleh karena itu, yang lebih rajih adalah pendapat jumhur ulama yang mengatakan bahwa hak hadhanah dikembalikan kepada ibu apabila ia telah bercerai dengan suami kedua, yang telah dikuatkan dengan hadis} dan kaidah fikih yang mengatakan bahwa, “Suatu hukum tergantung ada dan tidak adanya ‘illah.” Dan dilihat dari kemaslahatan seorang anak, yang mana ia masih membutuhkan kasih sayang dari seorang ibu.
Acil servise kafa travması ile başvuran hastaların yönetiminde optik sinir kılıf çapı ölçümünün değerlendirilmesi
Authors: CAN Özge , ERSEL Murat , YALÇINLI Sercan , KARBEK AKARCA Funda
Published: March 2023

Amaç: Literatürde ultrasonografik olarak optik sinir kılıf çapı ölçümünde saptanan değerler, kafa içi basınç artışı ile ilişkilendirilmektedir. Kafa içi basıncı ölçümü yapılan hastalar kritik alan ya da yoğun bakım hastalarıdır. Hafif ya da orta şiddette kafa travmasında patolojiyi ya da operasyona gidişi öngörmede ultrasonografi ile optik sinir kılıf çapı ölçümünün etkisi değerlendirilmemiştir. Çalışmamızda kafa travması ile başvuran hastaların, ultrasonografi ile optik sinir kılıf çapı ölçüm değerlerini, kraniyal tomografi bulguları ve hastaların klinik sonlanımları ile karşılaştırmayı hedefledik.
Gereç ve Yöntem: Prospektif kesitsel planlanan çalışmada acil servise başvuran kafa travmalı hastalar hafif, orta ve şiddetli beyin hasarı olarak değerlendirildi. Çalışmaya dahil edilen hastaların
ultrasonografi ile optik sinir kılıf çapları ölçüldü. Bulgular hastaların sonlanımları ve kraniyal tomografi özellikleri ile karşılaştırıldı.
Bulgular: Acil servise kafa travması ile başvuran 58 hastanın incelemesinde en sık hafif şiddette travmatik beyin hasarına rastlandı. Hastaların %51,7 (30)’sinde yatış ya da operasyon ihtiyacı vardı.
Optik sinir kılıf çapı ölçümlerinin ortalaması sağda 4,96±1,02 mm (3,1-7,3) solda ise 4,92±1,02 mm (3,3-7,8) olarak bulunmuştur. Optik sinir kılıf çapı ölçüm değerlerinin 5 mm ve üzerinde saptanması
hastaneye yatışı öngörmede istatistiksel olarak anlamlı olarak saptandı (p<0,05). Kraniyal tomografide patoloji varlığını ve kafa içi basınç artışını öngörmede optik sinir kılıf çapı ölçüm değerinin 5 mm üzerinde olması istatistiksel olarak anlamlı saptandı (p<0,05).
Sonuç: Kafa travması ile acil servise başvuran orta ve hafif kafa travması sınıfında da optik sinir kılıf çapı ölçüm değerleri, hastanın yatış ya da operasyon ihtiyacı hakkında bilgi verebilir, hastaların acil serviste monitörize izlem ihtiyacının belirlenmesi, görüntüleme önceliklerinin saptanmasında bir triaj kriteri olarak kullanılabilir.
Multimorbidities and polypharmacy in ageing hemophilia patients
Authors: DAVULCU Eren Arslan , DEMİRCİ Zühal , SAYDAM Güray , ŞAHİN Fahri
Published: March 2023

Aim: The aim of the study was to investigate whether multimorbidities, comorbidities, and therefore polypharmacy increase with age in hemophilia A and B patients followed in Ege University Adult Hemophilia and Thrombosis Center.
Materials and Methods: Adult hemophilia A and B patients were retrospectively evaluated. Patients'demographic data, medical information about hemophilic arthropathy, viral infections hepatitis C virus (HCV), body mass index (BMI), smoking and alcohol consumption, concomitant diseases, and all medications except factor replacement therapy were analyzed. Polypharmacy was defined as ≥5 drug use. Patients were compared by dividing into two groups: ≤55 years and >55 years.
Results: A total of 230 patients were evaluated (189 hemophilia A, 41 hemophilia B). There were 191 patients in ≤55 years (83%), and 39 patients in >55 years age groups (17%). The most common diseases in hemophilia patients were hypertension (19.5%), diabetes mellitus (10%), and gastroesophageal reflux disease-chronic gastritis (5.2%). The most common drugs that patients use
regularly were non-steroidal anti-inflammatory drugs (14.3%), proton pump inhibitors (12.1%), and oral antidiabetics (9.5%). The number of diseases not related to hemophilia (multimorbidity) and
polypharmacy in hemophilia patients aged >55 years was significantly higher than those aged <55 years (p values were 0.00 and 0.01 respectively). There was no difference between the groups in BMI, alcohol and cigarette use, and the history of HCV infection.
Conclusion: Our study showed that aging hemophilia patients have more multimorbidities and use more drugs than younger patients. For this reason, the importance of the effects of additional diseases and drugs on quality of life, treatment compliance, and hemostasis is increasing.
Nadir paranazal sinüs kanserlerinde yeni tanımlanan reseptör tirozin kinaz mutasyonları ve potansiyel fonksiyonel etkileri
Authors: GÖKER BAGCA Bakiye , GÖDE Sercan , TURHAL Göksel , ÖZATEŞ Neslihan Pınar , VERAL Ali , GÜNDÜZ Cumhur , AVCI Çığır Biray
Published: March 2023

Amaç: Paranazal sinüs kanserleri oldukça nadir görülen heterojen bir hastalık grubudur. Maksiler sinüs skuamoz hücreli karsinomu, paranazal sinüs kanserlerinin anatomik ve histolojik olarak en
yaygın alt tipidir. Bu kanserin genetik profiline dair bilginin sınırlı olması, hastaların hedefli tedavi seçeneklerinden yararlanamamasına neden olmaktadır. Çalışmamızda bu nadir kanserdeki reseptör tirozin kinaz mutasyonlarının tanımlanması ve mutasyonların olası fonksiyonel etkilerinin tahmin edilmesi amaçlanmıştır.
Gereç ve Yöntem: Bu amaçla 30 olgunun tümörüne ait FFPE dokulardan DNA izolasyonu gerçekleştirildi, olguların mutasyon profili yeni nesil sekanslama yöntemi ve biyoinformatik
değerlendirme ile belirlendi. Belirlenen patojenik/ olası patojenik varyantların fonksiyonel etkileri farklı in silico araçlar yardımıyla tahminlendi.
Bulgular: Olgularının tamamında en az bir adet patojenik/olası patojenik KIT, PDFGRA ve RETmutasyonu belirlendi. KIT geninin katalitik bölgesindeki mutasyonların kinaz aktivitesini arttıracağı
tahmin edildi. PDFGRA genindeki p.P567P ve p.D1074D mutasyonları, 30 olgunun tamamında ve SRA veritabanından elde edilen normal dokulara ait okumaların tümünde belirlendi.
Sonuç: Reseptör tirozin kinaz mutasyonlarının paranazal sinüs kanserlerinde de önemli rol oynayabileceğinin belirlenmiş olması özellikle artmış kinaz aktivitesini hedefleyen tedavi yaklaşımlarını
bu olguların erişimine sunma potansiyeli taşıması bakımından oldukça önemlidir.
Competence aspects in forensic expertise of documents
Authors: Cataraga Olga , Alămoreanu Sorin , Petkovich Petr
Published: March 2023

The technical expertise of documents, although it already seems to be a well-developed field, in the current stage faces many problems which need to be investigated. This especially concerns the limits of expert-examiners’ competences. Apart from the “classic” means of falsifying and counterfeiting documents, new ones constantly appear as the offenders gain new skills and equipment, which makes expertise much more complex.

In the present article, the authors attempt to discuss the limits of competences in the specialties of judicial expertise – code 6.01 (technical expertise of documents) and code 10.11 (examination of materials, documents, and writings). Exceeding one’s competence in carrying out the expertise cancels the evidence accumulated through scientific effort as well as entails disciplinary and often criminal liability of the expert-executor. The authors also propose an exemplary curriculum for training experts in forensic expertise of materials and documents and writings.
Evaluation of the sailent features in Indian currency notes
Authors: Sharma Sanya , Rohatgi Shipra , Mansour Saleh
Published: March 2023

Security features are topographies invisible to the naked eye, such as micro-printing or features visible in ultraviolet, transmitted, and oblique light. The present paper focuses on the examination of Indian currency notes such as 2000, 500, 200, 100, 50, 20, and10 in different light sources and with the help of a compound microscope. This kind of examination is very useful when it comes to distinguishing counterfeit currency from genuine one. Crime is increasing day by day, and so is the making of false currency – this study discusses the numerous security or hidden features which are invisible to the naked eye, and therefore may very well be missed by the potential perpetrator. It is the responsibility of the government along with the issuing authority to incorporate these structures into all travel and security documents, including passports, voter-id cards, and many others. These features are implemented either during the manufacturing of the paper itself (e.g., fluorescent fibres) or at the time of printing (e.g., microprinting, watermarks, and other fluorescent features).
“Variation” vs “individuality”: Redefinition in handwriting examination
Authors: Chih Chang Yun
Published: March 2023

The present article attempts to discuss the practical problems which have appeared in several recent cases, leading to converse conclusions and affecting the court trial as well as the rights and interests of the parties. The reinterpretation of “individuality” and “variation” can allow document examiners to use and interpret all the theoretical bases and methods of analysis, comparison, and judgment without any hesitation or uncertainty. It can also highlight the “basic theory” which must be applied differently depending on individual cases and in order to avoid analysis errors when non-professional document examiners reevaluate the same case.
Pilot study of unconventional food plant (UFP): adherence to nasturtium (Tropaeolum majus L.) in the diet and monitoring of biometric and clinical indicators
Authors: Faloni de Andrade Sérgio , da Graça Lopes Serrador Maria , Pereira da Silva Alda , Giacomelli Tavares Rejane , Monteiro Rodrigues Luis , Costa Maria do Céu
Published: March 2023

The flowers of Tropaeolum majus, popularly known as "capuchinha," garden nasturtium, nasturtium, Indian cress, or monks cress, are currently used worldwide as a food supplement and in plant-based diets, being added to smoothies, soups, mayonnaise and salads by consumers in search of sources of substances considered beneficial to human health. Most studies have shown nutritional qualities and beneficial effects of the plant, especially its flowers and respective aqueous extracts in vitro and in animals. Thus, this pilot study was designed to evaluate the acceptance and possible benefits of daily consumption of 20 g T. majus flowers per day for 30 days in healthy participants. Before and after ingestion, body composition, heart rate, blood pressure, and hematological and biochemical parameters were analysed. Results have shown good acceptance and safe use of T. majus flowers in a balanced and varied diet. However, it is important to highlight that this is the first exploratory study regarding these issues in healthy humans, and therefore, despite the widespread consumption described, additional studies are needed to deepen the results in biometric and clinical indicators in a larger number of volunteers. Keywords: Tropaeolum majus, unconventional food plant (UFP), nasturtium, edible flowers
Die Toilettenpapier-Krise und der Bullwhip-Effekt: Wird ein altbekannter Effekt neu entdeckt? : Eine retrospektive Betrachtung
Authors: Sucky Eric , Karl David
Published: March 2023

Die Lage im Einzelhandel zu Beginn der Corona-Pandemie stellte Logistiker vor Herausforderungen und die Verbraucher auf eine Geduldsprobe. Dies zeigte sich bei den Versorgungsengpässen für Toilettenpapier, die durch „Hamsterkäufe“ der Verbraucher ausgelöst wurden. Doch wie kam es zu dieser „Toilettenpapier-Krise“ und wie lange würde sie anhalten? Dieser Beitrag beschreibt eine retrospektive Einschätzung, wie sich bereits März 2020 der weitere Krisenverlauf abschätzen ließ. Anhand des im Supply Chain Management wohlbekannten Bullwhip-Effekts lassen sich Nachfrageschocks und die Auswirkungen auf die verschiedenen Stufen von Supply Chains analysieren. Im Falle der Toilettenpaper-Krise waren die Gründe für das Nachfragesignal für alle Institutionen offensichtlich. Es war also von Anfang an nicht von einem Bullwhip-Effekt zu sprechen: Der tatsächliche Toilettenpapier-Verbrauch ist langfristig konstant, was ein Aufschaukeln der Nachfrageschwankungen verhinderte.
Racismos e r-existências no Tocantins: um Estado “novo” estruturado em violências coloniais contra indígenas
Authors: Marques de Oliveira Júnior (Pankararu do Tocantins) Elvio Juanito , Srône (Xerente) Rogério , Hashizume Maurício
Published: March 2023

A ideia de que manifestações de racismo se dão apenas em situações mais acentuadas e escancaradas de preconceito e discriminação esconde a ocorrência de ordens sociais racistas que estruturam instituições, diretrizes e políticas públicas. Com base em revisão da temática de teorias e práticas relacionadas ao racismo, em especial em contextos periféricos, e a partir de realidades verificadas e vivenciadas no Estado do Tocantins, apresenta-se um panorama constituído de persistências e naturalizações do racismo contra povos indígenas por diferentes angulações. Criado em 1998 juntamente com a Constituição Federal de 1988, o Estado “novo”, ainda que se valha de reiteradas e múltiplas representações culturais de identidades associadas a indígenas desde as movimentações iniciais de formação do discurso e da articulação por autonomia, segue reproduzindo relações de hierarquia e subordinação em termos étnico-culturais. O contraste entre “indígenas desejados” e “indígenas negados” evidencia justamente esse duplo tratamento dispensado aos povos indígenas no Tocantins: por um lado, são reconhecidas a obrigatoriedade e a necessidade de políticas que possam considerar a diversidade; por outro, modelos são impostos “de cima para baixo”, reforçando lógicas desiguais sob o manto de uma pretensa interculturalidade. Tais formas de racismo, especialmente na área da educação, vêm sendo, entretanto, enfrentadas também por movimentos de r-existências.
Hypertension management in sub-Saharan Africa: an overview of challenges and opportunities for telemedicine
Authors: Gafane-Matemane Lebo F. , Mokwatsi Gontse G. , Boateng Daniel
Published: March 2023

Hypertension is the leading contributor to cardiovascular disease (CVD)-related deaths globally, with Africa being one of the World Health Organization regions with the highest prevalence of elevated blood pressure (BP). In sub-Saharan Africa (SSA), awareness, treatment, and control levels of hypertension remain low in both men and women and in different settings, including rural and urban areas. Important barriers to the management of hypertension in SSA are within health systems, usually overburdened by communicable and non-communicable diseases, acute medical conditions, and child and maternal healthcare. Health system-related challenges include the availability and cost of essential medicines and healthcare workforce constraints. At the patient level, individual barriers such as sociodemographic, economic, and psychosocial factors contribute significantly to the poor control of hypertension. Telemedicine presents a promising approach to improve the delivery of optimal care for individuals living with hypertension by serving as a connection between healthcare providers and patients. This may enhance access to isolated people living with hypertension, such as in rural areas. However, there is a concern that telemedicine may exacerbate some of the barriers to the management of hypertension in disadvantaged groups, such as those with limited access to digital technology, low education and literacy levels, and the ageing population. Therefore, the objective of this review is to summarize the current state of telemedicine use in the management of hypertension in SSA and discuss the challenges and opportunities to provide cost-effective, equitable, and sustainable access to digital health technology for people living with hypertension in SSA.
Luminescent alkynylplatinum(II) terpyridine-containing conjugated polymers: synthesis, characterization and photophysical studies
Authors: Cheng Heung-Kiu , Yam Vivian Wing-Wah
Published: March 2023

A series of alkynylplatinum(II) terpyridine complexes and alkynylplatinum(II) terpyridine-containing conjugated polymers with different polymer backbones has been synthesized, and their spectroscopic properties and Förster resonance energy transfer (FRET) processes has been investigated. The platinum(II)-containing polymers exhibit dual emissive features with emission maxima at ca. 416-465 nm and ca. 671-673 nm, which are assigned to be originated from singlet intraligand (1IL) excited states from the polymer backbone and triplet metal-metal-to-ligand charge transfer (3MMLCT) excited states from the platinum(II) pendants, respectively. The Förster radii (R0) of the platinum(II)-containing conjugated polymers have been determined, and their distinctive thermo-responsive luminescence changes have also been observed. The present work has demonstrated the utilization of “click” reaction for the preparation of platinum(II)-containing conjugated polymers, which show unique photophysical and spectroscopic properties. Through the judicious design, this type of platinum(II)-containing polymer is found to be sensitive to temperature, resulting in ratiometric emission changes. This study has provided valuable insights into the preparation of metal-containing polymeric systems for different applications.
Some aspects of the postcranial morphology of the Ural-Mugodzhar population in the Late Bronze Age
Authors: Grigorev A.P. , Zhanuzak R.Zh.
Published: March 2023

The paper reports on the osteometric data of skeletons from the burials of the Kozhumberdy group of the Late Bronze Age Alakul Culture (Southern Ural). The research is aimed to reveal the character of the variability of osteometric features of the sample group and its comparison with synchronous groups of the steppe zone of Eurasia. Twenty-four male and seventeen female skeletons were investigated. Taking into account the poor preser-vation of the material, a new method of identification of sex, developed by I.M. Sineva, was applied. The results of the study of the series by statistical methods (principal component analysis, nonparametric Mann — Whitney cri-terion) are presented. A high degree of morphological diversity of the variants of the skeletal development under the dominance of a rather gracile osteological complex within the Bronze Age of the steppe Eurasia is observed. Several individuals, characterized by the increased size of the skeleton, are distinguished. The similarity of the main part of the studied sample group with the synchronous population of the steppe-forest-steppe zone of the Cis-Urals and Upper Ob Basin is revealed. At the same time, the Kozhumberdy group morphologically differs from the agricultural population of the Bronze Age in Central Asia. These results indicate the main direction of the mor-phological links of the Kozhumberdy group of the Alakul Culture with the sample groups of the Sintashta Culture of the Cis-Urals and Andronovo Culture of Western Siberia. There is also present an insignificant component as-sociated with the Early Bronze Age population of the steppe Volga-Ural region (the Yamnaya Culture). The as-sumption made previously on the basis of the study of craniological materials about a single morphological basis for the formation of the population of the Alakul and Srubnaya Cultures of the Bronze Age is not confirmed. The main component in the formation of the physical appearance of the Srubnaya population is the local Volga-Ural population. As the morphological basis for the formation of the Alakul Ural-Mugodzhar group we consider the Sintashta population of the Cis-Urals.
Sacred objects from the sites of the Sargatka Culture in the context of interaction of the forest-steppe population with the nomads of the Ural-Kazakh steppes
Authors: Prokonova M.M.
Published: March 2023

The paper concerns the stone altars, clay dishes, and censers from the sites of the Sargatka Culture of the Early Iron Age. Analysis of their morphological features is carried out, as well as of the dynamics of changes in the forms, the context of their deposition in burials, and specifics of their use. As the result, the reasons for the appearance of these products in the forest-steppe zone of the Tobol-Irtysh and Baraba areas (Western Siberia) are clarified and their subsequent distribution in the given region is traced. Stone altars of types I, II, and IV started appearing in the 5th–4th cc. BC in the Irtysh Basin and Baraba regions as a consequence of the Saka mi-gration. Transformation of the religious and mythological views of the Sargatka population, as a result of the inter-actions of the Tobol-Irtysh communities with the nomads of the Ural-Kazakhstan steppes, led to the appearance of new rituals requiring small stone altars for their performance, due to which there was a growing demand for these products among local communities. However, by the 4th c. BC the production of altars in the Kazakhstan center ceased due to the decline of the Early Saka Culture. From this time, the population of the Sargatka Culture began making local copies of small type I altars from stone, although their production in the Sargatka area was difficult due to the lack of sandstone outcrops, which facilitated the use of more accessible material — clay, as reflected in the appearance of clay dishes of types III–V in the territory of the Baraba and Irtysh Basin. Connection between the local and imported products is indicated by the traces of their similar use. From the 3rd c. BC, scarce altars of type I could make their way into the Sargatka context as a result of close contacts with the population of the Upper Ob Basin, among whom these objects were widespread up until the 3rd–2nd cc. BC. The appearance of type III stone altars and type VI clay dishes in the complexes of the Sargatka Culture of the Tobol and Irtysh Ba-sins in the 5th–4th and 4th–3rd cc. BC might have been caused by the migration of a small group of nomads of the Southern Urals, or by close contacts with the population of the Gorokhovo Culture. Type V altars also were bor-rowed from the bearers of the Gorokhovo Culture. Their appearance may indicate the process of assimilation of the newly arrived Sargatka population in the Tobol Basin. In the 4th c. BC, clay dishes of type I appeared in the Irtysh Basin. From the 3rd c. BC, as a result of the intensification of contacts between the local population and nomads of the Sarmatian origin, these products became more widespread, while ceramic censers and clay dishes of type II also appeared.
The weapon complex of the Northern Altai population in the Xianbei period (on materials from the necropolis of Karban-I)
Authors: Seregin N.N. , Demin M.A. , Matrenin S.S.
Published: March 2023

The paper is aimed at introducing into the scientific discourse and complex interpretation of the weapon items discovered during excavations of the sites of the Bulan-Koby archaeological culture of the Karban-I ne-cropolis. This site, which comprises a series of burial mounds of the Great Migration Period, was partially investi-gated by the expedition of Barnaul State Pedagogical Institute in 1989–1990. The complex is located on the left bank of the Katun River, 1.7 km north-west of Kuyus village, in Chemalsky District of the Altai Republic. Weapons were found in five undisturbed male burials of the Xianbei period (mounds № 9, 11, 14, 33, 39). The finds ana-lyzed include long-range and close-range weapons: five compound bows; 14 iron arrowheads; four iron combat knives; and one dagger. Morphological analysis and classification of the objects, as well as their comparison with known artefacts of the last quarter of the 1st mil. BC — the first half of the 1st mil. AD from the sites of Central, Inner, and North Asia became the basis for conclusions concerning the determination of the dating of the pro-ducts. It has been found that the complex of weapons of the nomads who built the necropolis of the Bulan-Koby Culture at the mouth of the Karban River, was aimed at efficient countering of a lightly protected enemy and was appropriate for light cavalry and infantry. It includes both the already well-known (Xiungny) and new (local) modifi-cations of the offensive weapons. In terms of its diversity and level of development, this set of weaponry was sig-nificantly inferior to the military arsenals of the Xiongnu and Xianbei periods, as well as that of the population of the Bulan-Koby Culture of the late 3rd — 5th c. AD. The body of the conclusions made permits it to assume that the considered corpus of weapons reflects the initial stage of the evolution of the armament of the Altai population in the first half of the 1st mil. AD. The published materials expand the source base for the study of warfare of the population of Northern Altai in the Xianbei period. The obtained results of the chronological interpretation of diffe-rent categories of weapons can be used to refine the periodization of the sites of the Belo-Bom stage (2nd — 1st half of the 4th c. AD) of the Bulan-Koby Culture.
A new interpretation of the inscriptions on the handles of signature knives found on the shores of Sims Bay
Authors: Avdeev A.G. , Okladnikova Ye.A. , Svoiskii U.M. , Romanenko E.V.
Published: March 2023

The article reports on a new interpretation of the inscriptions on two personalized knives found on the coast of Sims Bay in the Laptev Sea. This interpretation differs from the readings published previously by paleographers and source-study experts due to the fact that it has been possible to devise correct transcription of these inscrip-tions with the aid of the method of non-contact 3D modeling of epigraphic records developed by the RSSDA Laboratory and used in the Code of Russian Inscriptions (CIR). The reading of the inscriptions on the signature knives proposed by the authors of this paper has enabled establishing their ownership to Gurii (baptismal name) — Akakii (prayer? name) Ivanov son of Karzyaev’s, likely the head of the commercial and industrial expedition of the 1620s. The site of the polar mariners of the 17th century in Sims Bay is located 70 km west of the island of Thad-deus Severny, where in 1940 members of the hydrographic detachment of the East Taimyr hydrographic expedi-tion found similar articles, including 8 other knives. Unfortunately, these knives have only partially preserved han-dles, and most of them turned out to be represented only by the blades. Inscriptions made in the Slavic ligature could be found only on two knives from a hut in Sims Bay. According to the official version, both sites belong to the members of the Russian trade and industrial expedition of the 17th century. The rich composition of the collec-tion of archaeological artifacts assembled at the locations of these two sites makes this monument unique for the Russian culture of the 17th century.
Fundamental aspects of leverage, profitability and financial distress as mediating variables that influence firm value
Authors: Hermuningsih Sri , Kusuma Hadri , Erawati Teguh , Rahmawati Anisya Dewi
Published: March 2023

This research aims to examine how leverage and equity affect firm value and financial distress as mediating factor in listed manufacturing firms on the Indonesia Stock Exchange. Such manufacturing businesses are the research's population. The manufacturing industry is the research sample from 2011 to 2021 periods. Purposive sampling was utilized in the sampling approach, resulting in data availability from 53 firms and 583 financial statement data—a structural equation model with structural equations for hypothesis testing. The test results demonstrate that leverage affects financial distress. Financial distress is negatively impacted by profitability. Leverage and financial distress negatively affect both firm value and financial distress, acting as a mediating factor. Conversely, profitability positively affects both firm value and financial distress, functioning as a mediating factor.
Assessing factors influencing people's intention to continuously use e-government systems
Authors: Rahman Arief , Pangendra Panji Randilla Apriama
Published: March 2023

This research aims to examine key factors influencing the intention to continuously use e-government systems. An online questionnaire was distributed to 251 users of e-government systems (Jogja Smart Service), and 231 respondents met the criteria. Researchers use PLS-SEM approach to examine the responses. The study found that system quality, service quality, information quality, and trust significantly positively affected user satisfaction. In comparison, self-efficacy has a positive but not significant effect on user satisfaction. Furthermore, user satisfaction significantly positively affects the intention to continue use. The continuous use of an e-Government service is proof of the success of a service. Hence, this paper identifies substantial factors for the continued use of e-government applications. This research modified previous research models by adding the factor of Trust, which is believed to be substantial for the continuous use of e-government systems.
Value of Safety of Anticoagulant Therapy in Elderly Patient with Atrial Fibrillation and High Risk of Bleeding
Authors: Vorobyeva N. M. , Tkacheva O. N.
Published: March 2023

The review article discusses  the safety issue of anticoagulant therapy in elderly patients with atrial fibrillation and high risk of bleeding.  An evidence base is presented demonstrating the high safety of rivaroxaban in patients over 80  years of age,  with a high risk of bleeding  and cardiovascular complications,  the presence of comorbid  pathology, geriatric syndromes  and chronic kidney disease (including in combination with anemia). The problem of low adherence to treatment in elderly patients and the possibility of solving it were separately considered.
Microbiota and Cardiovascular Diseases: Mechanisms of Influence and Correction Possibilities
Authors: Gorbenko A. V. , Skirdenko Y. P. , Andreev K. A. , Fedorin M. M. , Nikolaev N. A. , Livzan M. A.
Published: March 2023

The term "microbiota"  refers to the microbial  community  occupying a specific  habitat  with  defined  physical  and  chemical  properties  and  forming specific  ecological  niches.  The adult  intestinal  microbiota  is diverse.  It mainly  consists  of bacteria  of Bacteroidetes  and  Firmicutes  types.  The link between the gut microbiota  and cardiovascular disease (CVD) is being actively discussed.  Rapid progress  in this field is explained  by the development of new generation  sequencing methods and the use of sterile gut mice in experiments.  More and more data are being published about the influence of microbiota  on the development  and course of hypertension, coronary  heart disease (IHD), myocardial  hypertrophy, chronic heart failure (CHF) and atrial fibrillation (AF). Diet therapy,  antibacterial drugs,  pro- and prebiotics are successfully  used as tools to correct the structure of the gut microbiota of the macroorganism. Correction  of gut microbiota  in an experiment  on rats with coronary  occlusion  demonstrates  a significant  reduction in necrotic area. A study  involving  patients  suffering  from  CHF  reveals a significant  reduction  in the level of uric acid,  highly  sensitive C-reactive protein,  and creatinine. In addition to structural and laboratory changes  in patients with CVD when modifying the microbiota  of the gut, also revealed the effect on the course of arterial hypertension. Correction  of gut microbiota  has a beneficial  effect on the course of AF. We assume  that further active study of issues of influence and interaction of gut microbiota  and macroorganism may in the foreseeable future make significant  adjustments  in approaches to treatment of such patients.
Acute Coronary Syndrome during the Pandemic New Coronavirus Infection
Authors: Drapkina O. M. , Kravchenko A. Ya. , Budnevskiy A. V. , Kontsevaya A. V. , Ovsyannikov E. S. , Drobysheva E. S.
Published: March 2023

The experience of managing patients with COVID-19 around the world has shown that, although  respiratory symptoms predominate  during the manifestation of infection, then many patients can develop serious damage  to the cardiovascular system. However, coronary artery disease (CHD) remains the leading cause of death worldwide. The purpose of the review is to clarify the possible pathogenetic links between COVID-19 and acute coronary syndrome (ACS), taking into account which will help to optimize the management of patients with comorbid  pathology. Among the body's responses to SARS-CoV-2 infection, which increase the likelihood of developing  ACS,  the role of systemic inflammation, the quintessence  of which is a "cytokine storm" that can destabilize  an atherosclerotic  plaque is discussed.  Coagulopathy, typical for patients with Covid-19, is based on immunothrombosis, caused by a complex  interaction between neutrophilic  extracellular  traps and von Willebrandt  factor in conditions  of systemic inflammation. The implementation  of a modern strategy  for managing patients with ACS,  focused on the priority of percutaneous interventions (PCI), during  a pandemic is experiencing great  difficulties  due to the formation  of time delays  before  the start of invasive  procedures  due to the epidemiological situation. Despite this, the current European,  American and Russian recommendations for the management of infected patients with ACS confirm the inviolability of the position of PCI as the first choice for treating patients with ACS and the undesirability  of replacing  invasive treatment with thrombolysis.
Arrhythmic Mitral Valve Prolapse: New Menaces of the Known Disease
Authors: Kuzhel D. A. , Matyushin G. V. , Savchenko E. A.
Published: March 2023

Mitral  valve prolapse  (MVP) has  long  been  the subject  of intense  discussions regarding the prognosis and  follow-up tactics.  In most  cases,  this condition has a benign prognosis. However, recent autopsy and follow-up studies have shown risks of developing  sudden cardiac death (SCD) in some subgroups of patients who have this clinical phenomenon. The proposed  literature review uses the population  of patients with MVP with the highest probability  of developing  life-threatening ventricular tachyarrhythmias. Patients with the presence of a complex  of changes, including  bicuspid  MVP, negative T waves in the inferior and lateral leads on a standard  12-lead electrocardiogram (ECG), and a special anatomical  phenomenon called mitral annular  disjunction  (MAD), are at high  risk of developing  ventricular  ectopias  and VSS.  A reflection  of the high  risk of SCD  in such patients  is the increase of ventricular ectopy according to Holter monitoring. The presence of a bicuspid  MVP and the MAD  phenomenon, which is a separation  of the line of attachment  of the posterior mitral leaflet from the basal inferior wall segment  towards  the atrial wall, determines the presence of a special form of MVP,  the so-called  arrhythmogenic MVP.  Hence,  in most cases MVP has a benign  prognosis. However, patients with the aforementioned ar- rhythmic  MVP  signs  must  be given  particular  attention  and  annual  follow-up including  ECG  control,  Holter  monitoring and  echocardiographic examination of the heart to reduce the risk of ventricular tachyarrhythmias and SCD development.