bluuebunny/crossref_metadata_2025 huggingface dataset:
An Investigation into the Regenring Act in an ESP Reading and Writing Course
Authors: Suleimani Elaheh
Published: April 2022

Focusing on instruction of schematic structures and generic models are the primary characteristics of traditional genre pedagogy. What demands to be explored is how a particular knowledge structure could be reconfigured into a new genre. As a result, in this paper the effect of regenring in an ESP reading and writing course was investigated. For this purpose, two hundred and forty regenred annotations of writing were collected from twenty EFL participants in an ESP reading and writing course. It was found that regenring brought about genre awareness and changed the participants’attitudes toward their disciplinary topics and fields of study. Consequently, it may be assumed that regenring will contribute to awareness of how reconfiguration of knowledge in a new genre illuminates affordances and possibilities of a fresh experience and a new outlook on the subject matter. Due to its great potentiality, it is recommended to use regenring technique in writing pedagogy.
Exploring the Influence of Beliefs of Instructors on Adoption of Technology in Teaching
Authors: Hasan Zahir
Published: April 2022

The implementation of Emergency Remote Teaching (ERT) due to Covid-19 pandemic resulted in classes being taught online.  This research study examines computer-mediated instruction as it is influenced by beliefs of English-language instructors, and how those instructors make sense of their beliefs regarding computer-mediated online instruction tools.  An Interpretative Phenomenological Analysis (IPA) research design was used.  English-language instructors employed full-time in universities in Tokyo participated in this study.  It appeared that each instructor’s beliefs interacted in a complex manner to technology which impacted instructors’ teaching practices related to the use of computer-mediated instruction.  It revealed a multifaceted relationship between what instructors’ think and what they do in class in relation to computer-mediated tasks.  Findings of this study suggest that English language instructors are navigating competently, yet cautiously in the digital age.  This study suggests technology integration into the English language curriculum will require a greater collaborative effort by relevant stakeholders in recognizing instructors’ beliefs as vital to technology acceptance
Types of English Teachers’ Questioning and Classroom Interaction Affecting Learners’ Motivation in EFL Context
Authors: Hasanuddin Nurqadriyanti , Ciptaningrum Dyah Setyowati
Published: April 2022

The research aims to reveal the types of teachers’ questioning and classroom interaction that most affecting the EFL learners’ motivation. A mixed-method design was employed in this study with 30 students and a teacher as the respondents. The quantitative and qualitative data were gained through questionnaires and a structured interview for the students, and an observation checklist of the teaching process during three meetings. The data from the questionnaire were analyzed using Descriptive Statistics on SPSS Version 22. Moreover, the analysis of interview data was completed through data condensation, data display, and drawing/verifying conclusions. The observation checklist was used to reveal the kinds of questioning and classroom interaction that is frequently used by the teacher. Based on the quantitative data, it was found that the types of questioning affecting the students’ motivation were the leading, display, and open-ended questions. However, the types of questioning that the most frequently used by the teachers are referential and display questions. Moreover, the questionnaire result showed that the whole classroom and group interaction were the types of classroom interactions that most motivated the students in the learning process. From the observation, the teacher facilitated the student with various classroom interactions based on their need. Overall, the teacher has facilitated the students with the kinds of questioning and classroom interaction that motivates the student in learning.
Impact of online buying behavioral tendencies of Generation Z on their parents’ consumption behavior: Insight from Indonesia
Authors: Derbani Adnane , Rabiatul Adawiyah Wiwiek , Zulaikha Wulandari Siti
Published: April 2022

The generation gap has been present since the beginning of humanity and has symbolized one of the challenges of decision-making in families. It affects family members’ consumption behavior, namely buying decisions, and creates an interrelated impact on consumption behavior among family members. The aim of this study is to examine factors related to the parents’ perceptions of how the new online purchase behavior of their Generation Z children affected their consumption behavior. To meet the research objective, the paper has shed light on Generation Z’s new online purchase behavior. A survey was sent to 384 Indonesian parents of Generation Z children to collect their perceptions of consumption behavior. The data were then computed and processed using factor analysis, reliability analysis, regression analysis, as well as correlation and a t-test. The research results indicate that the new online purchase behavior of Generation Z children significantly affected their parents’ consumption behavior through different factors, such as online purchase illiteracy and self-control of consumption behavior. The findings also asserted that family consumption behavior is easily influenced by factors associated with parents’ perceptions. Moreover, this study also discussed the implications of the findings and identified the areas for future research.
Insights on the Practice of Hysterectomy among the Women Sugarcane Cutters in Maharashtra (India)
Authors: Shinde Saroj , Rakshase Bal
Published: April 2022

An issue of hysterectomy among the women sugarcane cutters in Maharashtra, India, was on the board of discussion in the year 2019. Women migrate every year to the sugar belt to harvest the sugarcane. There are different arguments and questions about this evil practice of hysterectomy. The present paper highlights the possible reasons for hysterectomies among women sugarcane cutters by analyzing the experiences of women with hysterectomies. It also illuminates the nature of work, ignorance of sugar factories, and health services towards the unique needs of women sugarcane cutters after their migration. This paper argues that the unfavorable circumstances in sugarcane cutting make women look after hysterectomy as an option to get rid of the pain during menstruation and work without interruption. Therefore, there is an urgent need for sugar factories and public health services to recognize their responsibilities towards this population group to stop the evil practice of removing the uterus.
Capitalismo e dominação imperial
Authors: Cocato Guilherme Pereira
Published: April 2022

Este texto objetiva expor as principais questões tratadas na obra “Modo de vida imperial: sobre a exploração dos seres humanos e da natureza no capitalismo global”, de Ulrich Brand e Markus Wissen, lançada no Brasil em 2021. Ressalta-se que o livro traz importantes contribuições para o debate atual acerca da crise ecológica global e do iminente colapso socioambiental que se torna cada vez mais palpável, caso não modifiquemos o curso de desenvolvimento de nossa sociedade. Nesse sentido, é indispensável que se coloque, tanto no cotidiano acadêmico quanto educacional em geral, reflexões críticas e significativas para o questionamento do modo de produção e acumulação vigente, bem como o modo de vida por ele gerado e que o sustenta. Esta é uma destas reflexões, que encontrará lastro material e necessidades urgentes impostas pela realidade desigual e degradante, nos âmbitos social e natural, que atinge quase que a totalidade dos territórios e povos do planeta.
Application of the artificial intelligence approach and remotely sensed imagery for soil moisture evaluation
Authors: Nourani Vahid
Published: April 2022

The current research attempts to present a modeling framework for determining soil moisture conditions by using remotely sensed imagery products. In this way, identifying various pixels with similar patterns from satellite images could be a reliable method to have an appropriate view over the soil moisture condition of a particular region. In this context, an artificial intelligence-based self-organizing map (SOM) method is employed to classify homogenous pixels over Phoenix, which is located in the south of Arizona, utilizing parameters extracted from satellite images. The central pixels of clusters are selected as the cluster indicator, with one from each cluster. Then, feed-forward neural networks (FFNNs) consisting of three layers of input, hidden, and output are trained by employing the extracted satellite images time series of the central pixels of the clusters. Finally, the soil moisture conditions of the representative pixels of the clusters are simulated by the trained models. The results reveal the suitability of SOM-based clustering to identify the specific points by which soil moisture can represent the soil moisture condition over the related regions. The proposed methodology and obtained results can be further used to provide a cost-effective method to determine the soil moisture condition of the region by reducing the costs of monitoring.

HIGHLIGHTS An SOM is used to cluster homogenous pixels. The soil moisture conditions of the representative pixel for each cluster are simulated by using an ANN. The results reveal the suitability of the SOM clustering method to identify the specific points by which the soil moisture can represent the soil moisture condition.
Granulation strategies applied to industrial wastewater treatment: from lab to full-scale
Authors: Caluwé M. , Goossens K. , Seguel Suazo K. , Tsertou E. , Dries J.
Published: April 2022

About one third of the industrial activated sludge (AS) plants worldwide suffer from bad settling sludge, often caused by filamentous bulking phenomena. The present study investigated the effectiveness of a sludge granulation/densification strategy, based only on a metabolic selection mechanism, to eliminate sludge bulking in a sequencing batch reactor (SBR) treating real industrial wastewater. The wastewater originated from a tank truck cleaning company transporting chocolate and beer. The proposed strategy involved the introduction of a slow unaerated/anaerobic feeding step in the SBR operation. On lab-scale, the new feeding strategy resulted in (1) excellent settling with a sludge volume index (SVI) decreasing from more than 300 mL·g−1 to 100 mL·g−1 and lower, (2) the elimination of sludge bulking genera and (3) the significant enrichment of glycogen-accumulating organisms (GAO), mainly Defluviicoccus and Candidatus Competibacter, and this in less than 80 days. The feeding strategy was then applied to the full-scale installation, yielding similar results: a stable average SVI of 37 mL·g−1 was reached after approximately 150 days. Full granulation was however not reached, which warrants further optimization. The present study shows that the proposed strategy can easily be applied in existing SBR systems to solve the problem of sludge bulking.
Cardiorenal Syndrome Triggered by Slowly Progressive Drugs Toxicity-Induced
Renal Failure along with Minimal Mitral Disease: A Case Report
Authors: Caiati Carlo , Argentiero Adriana , Favale Stefano , Lepera Mario Erminio
Published: April 2022

Background:

We report the case of a 93-year-old patient with normal left ventricular function and severe mitral annulus calcification, with mild mitral steno-insufficiency.

Case Presentation:

She had developed creeping drugs-induced renal toxicity that is generally totally overlooked, due mainly to statins, a proton pump inhibitor, and aspirin. The Na and fluid retention, along with hypertension that ensued, although not severe, caused acute heart failure (sub-pulmonary edema) by worsening the mitral insufficiency. This occurred due to a less effi-cient calcific mitral annulus contraction during systole and an increasing mitral transvalvular gra-dient, as the transvalvular mitral gradient has an exponential relation to flow. After the suspension of the nephrotoxic drugs and starting intravenous furosemide, she rapidly improved. At 6 months follow-up, she is stable, in an NYHA 1-2 functional class, despite the only partial recovery of the renal function.

Conclusion:

Progressive renal failure can functionally worsen even minimal mitral valvulopathy. Drug-induced nephrotoxicity can always be suspected in case of renal failure of unknown etiol-ogy. The suspension of the culprit drugs can improve renal function and dramatically improve the clinical symptoms even in a nonagenarian.
Uncommon Noninvasive Biomarkers for the Evaluation and Monitoring of the Etiopathogenesis of Alzheimer's Disease
Authors: Pomilio Alicia B. , Vitale Arturo A. , Lazarowski Alberto J.
Published: April 2022

Background:

Alzheimer´s disease (AD) is the most widespread dementia in the world, followed by vascular dementia. Since AD is a heterogeneous disease that shows several varied phenotypes, it is not easy to make an accurate diagnosis, so it arises when the symptoms are clear and the disease is already very advanced. Therefore, it is important to find out biomarkers for AD early diagnosis that facilitate treatment or slow down the disease. Classic biomarkers are obtained from cerebrospinal fluid and plasma, along with brain imaging by positron emission tomography. Attempts have been made to discover uncommon biomarkers from other body fluids, which are addressed in this update.

Objective:

This update aims to describe recent biomarkers from minimally invasive body fluids for the patients, such as saliva, urine, eye fluid or tears.

Methods:

Biomarkers were determined in patients versus controls by single tandem mass spectrometry, and immunoassays. Metabolites were identified by nuclear magnetic resonance, and microRNAs with genome-wide high-throughput real-time polymerase chain reaction-based platforms.

Results:

Biomarkers from urine, saliva, and eye fluid were described, including peptides/proteins, metabolites, and some microRNAs. The association with AD neuroinflammation and neurodegeneration was analyzed, highlighting the contribution of matrix metalloproteinases, the immune system and microglia, as well as the vascular system.

Conclusion:

Unusual biomarkers have been developed, which distinguish each stage and progression of the disease, and are suitable for the early AD diagnosis. An outstanding relationship of biomarkers with neuroinflammation and neurodegeneration was assessed, clearing up concerns of the etiopathogenesis of AD.
Research Progress of Novel Drug Delivery Systems of Chinese Medicine
Monomers based on Natural Silk Fibroin: A Mini-Review
Authors: Xu Hui , Xiang Ping , Yu Bin , Sun Zheng , Li Xuecheng , Qv Aimei , Sohail Muhammad , Li Yanli
Published: April 2022

Traditional Chinese medicine (TCM) has a good curative effect, but its disadvantages include
complex components, poor drug stability, potential drug interaction, etc. Therefore, it is particularly
important to construct a novel drug delivery system that can load Chinese medicine monomers to
solve this problem. Silk fibroin is a kind of natural polymer material with unique properties. It can be
used as a carrier material to load Chinese medicine monomers to prepare novel drug delivery systems
that significantly affect treating diseases without toxic and side effects. However, there is still a lack of
a review on silk fibroin as a carrier material to load Chinese medicine monomers to explore and analyze
the current research results and progress. Here, our article focuses on the in-depth excavation and analysis
of the recent research on novel drug delivery systems prepared by silk fibroin and TCM monomers.
Besides, the characteristics, existing problems, and prospects of silk fibroin are discussed and explained.
It is hoped that this research can provide a reference and basis for the modernization of TCM,
the design of novel drug delivery systems, the research and development of new drugs in the future, and
contribute to the innovation of silk protein.
Proteomic Profiling of Maternal Serum for Early Risk Analysis of
Preterm Birth
Authors: Roohi Nabila , Malik Javeria , Ahmad Shaaf , Aziz Humaira , Iqbal Muhammad Amir
Published: April 2022

Background:

The absence of absolute clinical indicators and suitable biomarkers hinders
the timely diagnosis of women at risk of preterm birth. It influences roughly 12% of births. At
delivery and clinical presentation, preterm births are generally inspected based on the gestational
period. Different disturbed pathways are associated with the signs of at-risk pregnancies.

Objective:

The main purpose of this study is to analyze and explore the serum proteome of early deliveries
and help health care professionals to improve the understanding of the progression of
preterm birth.

Methods:

In the present study, 200 pregnant females of 20-30 years of age were selected. We collected
samples of second and third-trimester pregnant females, out of which 40 females delivered
preterm. We further divided them into three groups, i.e., extremely preterm group, very preterm,
and controls. Overall comparison of serum profiles of all the three groups expressing fourteen proteins
ranging between 200-10kDa was made. Serum proteins were isolated by one-dimensional
sodium dodecyl sulfate-polyacrylamide gel electrophoresis and photographed by totalLab quant
software. Groups were evaluated using the ANOVA Tukey’s Post Hoc analysis.

Results:

Proteins of 69kDa and 15kDa expressed a significant decrease when compared with control
subjects. In contrast, the proteins of 23kDa expressed a significant increase, while the proteins
of 77kDa, 45kDa, and 25kDa demonstrated no considerable variation.

Conclusion:

The serum proteins showing significant difference as compared to the control group
will serve as predictive biomarkers for at-risk pregnancies. The present study is expected to considerably
improve the understanding of the disease pathogenesis along with improved diagnostic and
therapeutic approaches leading to better management of pregnancy and reducing the risk of
preterm birth.
Recent Advances in the Synthesis of Thiazole Ring: Mini Review
Authors: Kassab Asmaa E. , Shahin Inas G. , Mohamed Khaled O. , Taher Azza T. , Mayhoub Abdelrahman S.
Published: April 2022

The thiazole scaffold is an essential structural foundation in a plethora of pharmaceutical
products having an extensive array of biological activities. Consequently, its synthesis has been extensively
discussed in the literature. In this mini review, we have summarized the recent advances in thiazole
synthesis, covering articles published between 2002 and 2021. We have reviewed and discussed
various recent and novel routes for synthesizing compounds containing thiazole rings from various
starting materials such as thiourea, thioamide, or thiosemicarbazone. Additionally, we have illustrated
environmentally benign methods for thiazole synthesis. We hope that this review can help other researchers
efficiently synthesize the thiazole ring.
Assessment of Expression of LncRNA H19, Pinin and their Relation to
rs532 Single Nucleotide Polymorphism in the Pinin Gene Present in the
Tissue of Individuals Suffering from Breast Cancer in Central Iran
Authors: Nabatchian Fariba , Shafieizadeh Zohreh , Shafieizadeh Zahra , Moradi Afshin , Kheiri Fatemeh , Azadeh Mansoureh , Afrisham Reza , Davoudi Negin
Published: April 2022

Introduction:

In women, breast cancer is a prevalent malignancy. One of the important
genes in breast cancer progression is Pinin. LncRNAs H19 plays an important role in breast cancer
cell development. In this study, the correlation between a miRNA-related rs532 polymorphism (G)
and the level of expression of Pinin and lncRNA H19 in breast cancer tissues was investigated.

Methods:

Tissue samples were collected from 64 patients with breast cancer. RT-PCR with highresolution
melting (HRM) analysis was used.

Result:

Our data suggest that there is significant up-regulation in the expression of lncRNA H19
and the Pinin gene in breast cancer tissue compared to the control ones. The Pinin polymorphism
rs532 G is significantly associated with Pinin expression of breast cancer tissue compared to the
control one.

Discussion:

The rs532 G polymorphism is located around the pinin and its allele frequency is significantly
associated with Pinin expression. Perhaps, rs532 G polymorphism could be functional in
breast cancer progression through the impact on pinin expression. There is no correlation between
SNP and lncRNA H19.

Conclusion:

The polymorphism rs532 G polymorphism is significantly associated with Pinin expression
of breast cancer tissue from Isfahan patients which suggests the miRNA-141has potential
to regulate Pinin expression levels.
A Comprehensive Review on Ethnopharmacology and Phytochemistry of
an Underutilized Plant Cordia dichotoma L.
Authors: Kushwaha Poonam , Abdullah Mohammad , Usmani Shazia
Published: April 2022

Cordia dichotoma L. (Family Boraginaceae), a well-known medicinal plant, has been
traditionally used for thousands of years for the treatment of various diseases. Several studies
have been undertaken to assess the pharmacological potential of different parts of the plant,
namely roots, stem, flower, and leaves, for their antioxidant, antimicrobial, hepatoprotective, antidiabetic,
anticancer, antifertility, antifungal, and wound healing properties. The present review
aims to deliver a comprehensive summary of botany, traditional uses, phytochemistry, and prospects
of potential pharmacological activities of the plant C. dichotoma. A literature survey was
carried out through books on herbal medicine and different online databases, including Google
Scholar, PubMed, Scopus, Scifinder, Science Direct, and Springer. All papers based on traditional
medicinal uses and pharmacological properties have been analyzed and summarized in this review.
The elaborative results vindicate that extracts and phytoconstituents from C. dichotoma
exert a wide spectrum of pharmacological effects and hold significant prospects in major health
conditions.
Reperfusion Cardiac Injury: Receptors and the Signaling Mechanisms
Authors: Maslov Leonid N. , Popov Sergey V. , Mukhomedzyanov Alexandr V. , Naryzhnaya Natalia V. , Voronkov Nikita S. , Ryabov Vyacheslav V. , Boshchenko Alla A. , Khaliulin Igor , Prasad N. Rajendra , Fu Feng , Pei Jian-Ming , Logvinov Sergey V. , Oeltgen Peter R.
Published: April 2022

It has been documented that Ca2+ overload and increased production of reactive oxygen species play a significant role in reperfusion injury (RI) of cardiomyocytes. Ischemia/reperfusion induces cell death as a result of necrosis, necroptosis, apoptosis, and possibly autophagy, pyroptosis and ferroptosis. It has also been demonstrated that the NLRP3 inflammasome is involved in RI of the heart. An increase in adrenergic system activity during the restoration of coronary perfusion negatively affected cardiac resistance to RI. Toll-like receptors are involved in RI of the heart. Angiotensin II and endothelin-1 aggravated ischemic/reperfusion injury of the heart. Activation of neutrophils, monocytes, CD4+ T-cells and platelets contributes to cardiac ischemia/reperfusion injury. Our review outlines the role of these factors in reperfusion cardiac injury.
Skin Cancer Management: Current Scenario And Future Perspectives
Authors: Nagpal Manju , Jindal Mehak , Kaur Malkiet , Singh Manjinder , Aggarwal Geeta , Dhingra Gitika Arora
Published: April 2022

Skin cancer is a life-threatening disease and has caused significant loss to human health
across the globe. Its prevalence has been increasing every year and is one of the common malignancies
in the case of organ transplant recipients, of which 95% constitute basal cell and squamous cell
carcinomas. The prime factor causing skin cancer is UV radiation. Around the 20th century, sunlight
was the primary cause of skin cancer. A novel hypothesis by US scientists stated that cutaneous
melanoma was mainly due to recurrent exposure to the sun, whereas keratinocyte cancer occurred
due to progressive accumulation of sun exposure. Management of skin cancer is done via
various approaches, including cryotherapy, radiotherapy, and photodynamic therapy. Post-discovery
of X-rays, radiotherapy has proven to treat skin cancers to some extent, but the indications are uncertain
since it depends upon the type of tumour and surgical treatment required for the patient. Due
to various limitations of skin cancer treatment and increased severity, there is a requirement for
cost-effective, novel, and efficient treatment. Various nanocarriers such as SLNs, magnetic nanoparticles,
gold nanoparticles, carbon nanotubes, etc., are the potential carriers in the management and
prognosis of both non-melanoma and melanoma skin cancer. Various research and review databases
and patent reports have been studied, and information compiled to extract the results. The review
also discusses the role of various nanocarriers in treating and diagnosing skin cancer.
UHPLC-MS/MS Studies and Antiproliferative Effects in Breast Cancer Cells of
Mexican Sargassum
Authors: José Correa-Basurto , Jonathan Fragoso-Vázquez Manuel , Darling Duclosel , Cecilia Rosales-Hernández Martha , Alan Estrada-Pérez , Lubriel Mendoza-Figueroa Humberto , Ivonne Olivares-Corichi , Elena Mendieta-Wejebe Jessica , Augusto Reyes-López Cesar , Sayuri Velasco-Quijano Jessica , Angel Gil-Ruiz Luis
Published: April 2022

Background:

Sargassum is a marine organism that, under specific conditions, drastically increases its population
damaging the environment and risking other organisms. However, sargassum could represent a source of bioactive
compounds to treat different diseases such as cancer. Thus, aqueous, ethanolic, and ethyl acetate extracts of sargassum
from Playa del Carmen, Mexico, were subjected to metabolomic and antiproliferative assays in breast cancer
cells.

Objective:

To evaluate the biological effect of different extracts of sargassum, its toxicity over Artemia salina and its
antiproliferative effect tested in MCF-7, MDA-MB-231, and NIH3T3 cell lines. Finally, using UHPLC-MS/MS to
identify the metabolites in each extract to correlate them with its antiproliferative effect.

Methods:

The sargassum sample collection was carried out in September at three different points in Playa del Carmen,
Quintana Roo, Mexico. The aqueous, ethanolic, and ethyl acetate extracts of Mexican sargassum were obtained by
evaporation of solvent and lyophilization. Then, these extracts were evaluated in the cytotoxicity bioassay of Artemia
salina. Next, its antiproliferative effect was assessed in MCF-7, MDA-MB-231, and NIH3T3 cell lines. Using
UHPLC-MS/MS, the metabolites present in each extract were identified. Finally, docking studies on sphingosine kinase
1 (PDB ID: 3VZB) of sphingosine were carried out.

Results:

The extracts from sargassum showed a greater effect in the antiproliferative assays in cells than in cytotoxic
assays in Artemia salina. The ethanolic extract obtained from sargassum showed the best antiproliferative activity in
MCF7 and MDA-MB-231 cells. Despite its antiproliferative effect on NIH3T3 cells, an additional extract is required
indicating that this extract has compounds that could have a better effect on cancer cells in fibroblast (NIH3T3). The
UHPLC-MS/MS of ethanolic and the ethyl acetate extract showed that these extracts have compounds such as sphinganine
C16, N, N-Dimethylsphingosine compound, and that it could be possible that the effect observed is due to their
metabolites which could be ligands for the sphingosine kinase 1 as demonstrated by docking studies.

Conclusion:

The ethanolic extract obtained from sargassum has better antiproliferative activity, despite not having a
cytotoxic effect in Artemia salina. The antiproliferative effect could be related to the sphinganine C16, N,NDimethylphingosine
identified with more abundance by UHPLC-MS/MS. In addition, these metabolites could be
targets of sphingosine kinase 1.
Upregulation of Beta 1 and Arachidonic Acid Metabolizing Enzymes in the
Mouse Hearts and Kidneys after Sub Chronic Administration of Rofecoxib
Authors: Jarrar Yazun , Askar Noor , Gharaibeh Munir , Alqudah Mohammad
Published: April 2022

Background:

An imbalance in the levels of arachidonic acid (ARA) metabolites in cardiovascular
disorders and drug-induced cardiotoxicity have been previously described.

Aims:

This study aimed to investigate the influence of cyclooxygenase-2 (COX-2) selective inhibitors on
the gene expression of ARA-metabolizing genes and beta1 gene in the hearts and kidneys of experimental
mice.

Methods:

Thirty-five balb/c mice were divided into five groups with seven mice per group. The groups
were then given two distinct types of COX-2 selective inhibitors, rofecoxib and celecoxib, in two different
doses equivalent to those used in human treatment for 30 days. The mRNA expression of beta1, ace2, and
ARA-metabolizing genes, coxs, lipoxygenases (aloxs), and cytochrome p450 (cyp450s) in mice heart and
kidneys were assessed. Genes were analyzed using real-time polymerase chain reaction analysis. In addition,
rofecoxib-induced histological alterations were examined.

Results:

It was found that only the high dose of rofecoxib (5 mg/kg) caused toxicological alterations, a
finding that was indicated by a significant increase (P < 0.05) in the relative weight of the mouse hearts
and increase in the ventricle wall thickness as observed through pathohistological examination. This increase
was associated with a significant increase in the mRNA expression level of the beta1 receptor in
both the heart and kidneys of the mice (53- and 12-fold, respectively). The expression of both cox1 and
2 genes was increased 4-fold in the kidneys. In addition, the expression of the alox12 gene increased
significantly (by 67-fold in the heart and by 21-fold in the kidney), while alox15 gene expression was
upregulated in the heart by 8-fold and 5-fold in the kidney. The genes responsible for synthesizing 20-
Hydroxyeicosatetraenoic acid (cyp4a12 and cyp1a1) were significantly upregulated (P < 0.05) in the
hearts of high-dose rofecoxib-treated mice by 7- and 17 -fold, respectively. In addition, the expression of
epoxyeicosatrienoic acid-synthesizing genes, cyp2c29 and cyp2j5, was increased significantly (P < 0.05)
in the hearts of high-dose rofecoxib-treated mice by 4- and 16-fold, respectively.

Conclusion:

Rofecoxib caused upregulation of the mRNA expression of the beta 1 gene in association
with increased expression of ARA-metabolizing genes in mouse hearts and kidneys. These findings may
help us understand the molecular cardiotoxic mechanism of rofecoxib.
Mechanical Energy Harvesting System from the Human Arm Movement
for Continuous Blood Pressure Measurement
Authors: Lifi Houda , Alaoui-Belghiti Amine , Lifi Mohamed , Khrissi Salam , Nossir Naima , Tabbai Yassine , Benjellοun Mohammed
Published: April 2022

Background:

In this article, an approach to harvesting electrical energy from a mechanically
excited piezoelectric element has been described. Three PMN-xPT compositions were used with x
taking the values of 0.31, 0.33, and 0.35 in order to study the most important properties of piezoelectric
PMN-PT in energy harvesting.

Objectives:

This study uses a detailed analysis of three Relaxer (1-x)PMN-xPT ceramic compositions,
emphasizing the influence of content on piezoelectric, dielectric, and electromechanical characteristics.

Methods:

Prototypes have been made and characterized, validating these energy thresholds. From this
comparative analysis of the three compositions, it was found that PMN-35PT has the highest recoverable
energy density. On the other hand, the pressure change in the radial artery was calculated using
the pressure sensitivity of the sensor and systolic and diastolic characteristic points in the pressure
pulse wave (PPW).

Results:

The results show that piezoelectric, dielectric, and electromechanical properties are all directly
associated with chemical composition and that the examined ceramics outperform their PZT counterparts,
making them very suitable for energy harvester systems and sensing device applications.
Therefore, the structure developed is an external patch of 5x3cm², placed on the arm and able to recover
3.46 mW for PMN-35PT during human walking.

Conclusion:

Results indicate that the suggested method demonstrated reliable accuracy of systolic
blood pressure (SBP). The technology has the potential to be used for long-term continuous blood
pressure monitoring. The piezoelectric sensor was placed on the skin above the radial artery and
measured for 10 sec to obtain the continuous pressure waveform.
Pathogenic Roles of m6A Modification in Viral Infection and Virus-driven Carcinogenesis
Authors: Wang Jia-Feng , Cai Wei , Qiu Fen-Sheng , Yu Chen-Huan
Published: April 2022

N6-methyladenosine (m6A) is a prevalent modification of RNA in eukaryotes,
bacteria, and viruses. It is highly conserved and can affect the structure, localization, and
biology functions of RNA. In recent years, multiple m6A methylation sites have been identified
in the viral RNA genome and transcripts of DNA viruses. This modification occurs commonly
during the primary infection and is dynamically regulated by a methyltransferase (writers),
demethylase (eraser) and m6A-binding proteins (readers) within the host cells. The abnormal
m6A modification not only affects the replication of pathogenic viruses and host immune
response but also contributes to the pathogenesis of virus-induced cancers. In this review, we
highlight recent advances on the mechanism of m6A modification on viral replication, host
immune response and carcinogenesis to provide a novel insight for epigenetic prevention of
viral infection and virus-driven carcinogenesis.
Assessing conceptual dimensions of quality service
Authors: Syaiful Syaiful , Astuty Pudji
Published: April 2022

The study aims at examining various literatures on service quality dimensions to dupe prefers strategy and policy for service oriented organizations. It also aspires to identify the relative importance of service quality dimensions analysis as one of the most important factors which influence the organization directly. This study also introduces the ROPMIS quality dimensions. This study, fully focused on service quality issues, will help to understand service dimensions issues for an organization of the earlier research work, which can be followed by service sectors to promote true quality service. Moreover, this model can be guideline for the top levels managers to understand the different aspects of service quality dimensions so that they can be able to choose the right dimensions and instruments to offer competitive service for the sate of holding sustainable growth and profitability of the organizations.
Evaluation of atrazine 50% WP herbicide for weed control in Maize (Zea mays L.) of Jhabua hills zone of M.P
Authors: SINGH MAHENDER , KUMAR MANISH , TOMAR I. S. , MORYA JAGDEESH
Published: April 2022

A field experiment was conducted during kharif season of 2015 at Zonal agricultural research station, Jhabua with the objective to assess the bio-efficacy of atrazine herbicide against complex weed flora and yield of maize crop. The experiment consisted of six treatments, was laid out in randomized block design with three replications. Results revealed that all the weed control treatments significantly reduce the weed density and weed dry matter at 30 and 60 DAS. Atrazine 50% WP @ 1 kg/ha significantly reduced the weed count of grassy as well as broadleaved weeds at 30 and 60 DAA and found at par with Atrazine 50% WP @ 1.5 kg/ha and Atrazine 50% WP @ 2.0 kg/ha. However, better efficacy was observed with higher dose of atrazine viz., Atrazine 1.5 kg and 2.0 kg/ha. Hand weeding was also found as an effective tool for controlling the weed biomass at early stage of observation (30 DAS) but on later stage of crop it proves less effective due to emergence of weeds which further reduce the yield. Further, maize yield (43.43 q/ha) was also found significantly superior in Atrazine 1.0 kg/ha as compared to Atrazine 0.5 kg/ha, hand weeding a 20 DAS and control plot and found at par with higher doses of atrazine. Highest net return of Rs 43203/ha and B:C ration of 3.43 was observed in Atrazine 1.5 kg/ha.
Assessment of dwarf genotypes in litchi (Litchi chinensis Sonn.) based on some trunk and leaf characteristics
Authors: Hazarika J. , Lal Narayan , Pandey S. K. , Nath Vishal
Published: April 2022

Studying the relationship between trunk quantitative parameters and tree growth and vigour in litchi is crucial for estlablishing the basis of dwarfing in different genotypes. Observation on plant height, trunk girth, bark area of trunk, xylem diameter, xylem area, xylem transversal area, bark transversal area, trunk transversal area, bark:wood ratio, rachis length, leaf blade length, dry weight of leaf were recorded on 30 litchi genotypes, having diverse growth habit. Data were subjected to correlation analysis. A positive correlation of plant height was found with trunk girth, rachis length, leaflet blade length and dry weight of leaf which was observed which also exhibited strong positive correlation with xylem diameter, xylem area and xylem transversal area. Similarly, bark area had a very strong positive correlation with bark:wood ratio but was negatively correlated with plant height, trunk girth, xylem diameter, xylem area and xylem transversal area. In litchi, dwarf genotypes have higher bark area and bark:wood ratio compared to vigorous ones. Using these parameters as criteria for screening the dwarfing genotypes would be useful to generate the information for differentiating between genotypes with varying growth and vigour.
Seed-borne mycoflora of important oilseeds of Nagaland
Authors: Debbarma Anamika , Banik Susanta
Published: April 2022

The present investigation was carried out to identify fungal infection of five oilseeds viz., rapeseed, mustard, soybean, sesame and perilla oilseeds via different seed health testing methods and seed germination. A total of six seed-borne fungi Aspergillus sp., Colletotrichum sp., Rhizopus sp., Penicillium sp., Nigrospora sp. and Trichoderma sp. were detected from the five oilseeds collected from local market of Medziphema, Nagaland. Amongst the seed health testing methods employed, PDA method was proved to be superior to blotter paper method and water-agar method. The fungal occurrence is more in PDA method with mean incidence of seed mycoflora 15.77%. The predominant fungus was observed to be Trichoderma sp. with 40.67% incidence and the least fungal incidence was of Nigrospora sp. (1.33%). Among the oilseeds, soybean seeds showed highest incidence of seed mycoflora (14.81%) and the lowest incidence of 4.24% was recorded from perilla seeds. The highest germination of oilseeds was recorded in PDA method (50.33%) followed by water-agar method (45.67%).
Design and Development of Low Cost Solar Powered Automobile System for Eco-friendly Transportation
Authors: Modi Vinit V. , Modi V. M. , H. Sanchavat
Published: April 2022

Solar car can be categorized as a ‘green vehicle’ with zero carbon emission. With an aim to develop low cost eco-friendly commuting system, a prototype of solar car has been designed and developed in the College of Renewable Energy and Environmental Engineering, S.D. Agricultural University, S.K. Nagar, India. Engine and transmission system of anold petrol car were completely removed to refurbish it by Variable Drive Brushless Direct Current Motor (VBLDC), battery bank, control mechanism, sensors and solar modules. 48 V, 105 Ah Valve Regulated Lead Acid (VRLA) tubular thin plate battery bank was designed to operate a VBLDC motor of 1248 W capacity. 300 Wp polycrystalline solar array has been installed on the car rooftop to deliver synchronized power through charge controller. Results revealed thatin the course of insolation array of 5.0-6.00 kWh/m2, the solar modules were found to deliver consistent Voltage in between 71 V to 83 V, sufficient to charge battery bank reliably through the protection ofMaximum Power Point Tracker(MPPT) charge controller.Maximum instantaneous power values found were 224.84 W and 222.98 at corresponding voltage and current measurement of 49.2 V, 4.57 A and 48.9 V, 4.56A respectively. The battery bank took complete two days to achieve full charging status of 52.1 V when charged by solar array. Lab test showed that the car kept working for 2 hours and 57 minutes till the battery bank gets exhausted to 40.4 V. During field test the solar car performed for 1 hour and 50 minutes at an average speed of 30 km/h. Life Cycle Cost of solar car was found about five times less as compared to traditional petrol car.When compared with petrol car, average payback period and CO2 emission reduction were found to be about 02.32 years and 1679 kg/year.
Performance of Stress Tolerant Rice Variety Swarna Shreya Under Rainfed Drought-Prone Areas of South Eastern Ghat Zone of Odisha
Authors: DASH1 S. R. , ROUTRAY B. K. , DAS HIMANGSHU , BEHERA N.
Published: April 2022

Stress like drought is an important production constraint that drastically reduces rice yield. The present study was conducted during kharif season of 2019 through the front line demonstrations in Malkangiri district of South Eastern Ghat Zone of Odisha to evaluate the performance of drought tolerant rice variety Swarna Shreya with recommended package (demonstrated technology) of practices. Rice variety Sahabhagi dhan was considered as local check (farmers practice). Performance of Swarna Shreya was better in terms of plant height (110.4 cm), number of tillers hill-1 (17.8), panicle length (23.5 cm), number of grains panicle-1 (162), test weight (23.4 g) with yield of 42.4 q ha-1. In terms of yield, it was 15.2% more with Swarna Shreya as compared to local check Sahabhagi dhan. Highest economic return with more B: C ratio (1.8) was also recorded with Swarna shreya. So, drought tolerant rice variety Sahabhagi dhan can be replaced with Swarna Shreya for more yield and higher economic return in rainfed upland ecosystem of South Eastern Ghat Zone of Odisha.
High Beta Carotene Discovered in Kalanamak of Rice (Oryza sativa L.)
Authors: Chaudhary R. C. , Singh Smriti , Yadav Ritima , Das Swapna , Sahani Anjali
Published: April 2022

Kalanamak rice is a unique cultivar of Oryza sativa L. where Beta Carotene is present. In the freshly harvested grain, the Beta Carotene is 0.42 mg / 100 g, and in one year old sample it is 0.18g / 100 g. Total carotenoids in the these samples were 0.51 and 0.31 respectively. Beta Carotene of Kalanamak needs to be studied further for its conversion rate into Vitamin A. Through various breeding methods, amount of Beta Carotene needs to be increased for remedying Vitamin A Deficiency in the human population. Along with high aroma, high Iron, high Zinc and high protein, semi-dwarf varieties of Kalanamak will be the unique rice of the world. It is non-GMO unlike Golden Rice, and thus non-controversial in consumption and promotion.
Prospects and functionality of bacterial exopolysaccharides in dairy foods: A Review
Authors: KUMAR SURYAMANI , KUMAR SANJEEV , BUMBADIA MITUL , SINGH SUDHIR KUMAR
Published: April 2022

Lactic acid bacteria (LAB) produces exopolysaccharides (EPS), which are used to make fermented dairy products like dahi, yoghurt, cheese, fermented cream, and milk-based desserts.EPS synthesis by LAB varies greatly in terms of quantity, chemical compositions, molecular size, charge, presence of side chains, and molecule rigidity. Firmness and creaminess are two main sensory qualities that influence customer preference for dairy products.EPSs can perform as texturizers and stabilisers, raising the viscosity of a final product and boosting the rigidity of the casein network by binding hydration water and interacting with other milk constituents such proteins and micelles.As a result, EPS can help to reduce syneresis and improve product stability. The application of EPS in a dairy food matrix remains a challenge in order to better meet customer demand for appealing, flavorful, and even healthier products.
Response of lentil to application of potassium and potash solubilizing bacteria
Authors: Bhat Tauseef A , Kanth Raihana Habib , Jan Seerat , Nazir Aijaz , Jan Bisma , Mir Mohd Salim , Lone Bilal Ahmad , Singh Lal
Published: April 2022

A study was conducted to estimate the effect of potassium and KSB on the growth and yield of lentil at SKUAST-K during rabi 2019 and 2020. The experiment was laid out in randomized complete block design with eight treatments (Control, 10 kg K/ha, 20 kg K/ha, 30 kg K/ha, KSB, 10 kg K/ha + KSB, 20 kg K/ha + KSB and 30 kg K/ha + KSB) replicated thrice. Application of potassium alone or in combination with KSB had a significant effect on growth and yield of lentil. The combined application of 30 kg K/ha + KSB recorded highest the plant height (28.55 cm), pods per plant (49.93) and seeds per pod (1.87) but statistically at par with application of potassium at 30 kg/ha alone. The lowest value of growth and yield attributes was recorded in control treatment. The highest grain yield of 6.81 q/ha was observed with combined application of 30 kg K/ha + KSB which was at par with potassium application @ 30 kg/ha alone with the lowest yield recorded in control treatment. The experiment indicated that potassium application alone or in combination was found to have a significant impact on lentil growth and yield.
Chickpea performance influenced by inorganic fertilizer, biofertilizers and micronutrients and their residual effects on succeeding fodder sorghum
Authors: Chaudhar J. H. , Sadhu A C , Sonani V V. , Chauhan S A
Published: April 2022

A field experiment was conducted at Agricultural Research Station, Anand Agricultural University, Derol during the rabi and summer seasons of 2013-14 and 2014-15 to determine the effect of inorganic fertilizer, biofertilizers, and micronutrients, as well as their interactions, on chickpea growth, yield attributes, and yield, as well as their residual effect on succeeding fodder sorghum.Results indicated that fertilizer levels treatment F3i.e., 100 % RDF (25-50 kg NP ha-1)had significant influence on growth and yield attributing characters like plant height,number of branches plant-1,number of nodules plant-1, number of pods plant-1and also on seed and straw yields of chickpea as compared to treatments F2 (75 % RDF), F1(50 % RDF) and F0 (Control).The residual effect of treatment F3 (100% RDF) had also significantinfluenceon the green fodder yield, dry fodder yield and crude protein content of succeeding fodder sorghum.When compared to B0 (control), the biofertilizers treatment B1 (PSB + Rhizobium @ 5 ml kg-1 seed each) produced significantly higher growth, yield, and yield of chickpea.Application of micronutrients treatment M1(Micronutrient mixture grade-V @ 20 kg ha-1) produced significantly highernumber of branches plant-1, number of nodules plant-1number of pod plant-1, seed yield and straw yield as compared to untreated control (M0).Treatment combination F3B1M1 produced significantly the highest 85 nodules plant-1, number of pods plant-1, seed and straw yields of chickpea, but it was statistically at par with treatment combination F2B1M1 during both the years and on pooled basis.
Effect of zinc and boron foliar application on growth, biomass production and yields of spring-summer okra
Authors: Singh Durgesh , Bahadur Anant , Singh Anish K. , Singh H. K. , Yadav Sapana , Singh D R.
Published: April 2022

Micronutrient study (Zn and B) in okra was carried out at Vegetable Farm of P.G. College, Ghazipur, Uttar Pradesh. Treatment comprised of two foliar spray of Zn (50 and 100 ppm) and Boron (25 and 50 ppm) solely or in their combinations. Thus, a total of 9 treatments including control (water spray) were replicated thrice. Micronutrient sprays were done twice at 30 and 45 days after sowing.The highest values for plant height (66.50cm),total drymatter production (51.30 g), root area (234.34 cm2) and root length density (1486.87 cm/cm3),fruits/plant (24.33), fruit yield (38.22 g/ plant or 102.56 q/ha) were recorded for combination spray of Zn(50ppm) + B(25ppm). This treatment registered 23.18% higher fruit yield over control.