bluuebunny/crossref_metadata_2025 huggingface dataset:
Inflammation and digestive reflux in the pancreatic stump after pancreaticoduodenectomy subtitle: Mechanisms of pancreatic fistula
Authors: Wang Tiegong , Tian Liang , Zhang Xiaoling , Xu Yanfeng , Che Yanxu , Zhang Lei , Zhao Xiulei , Kong Deshuai , Luo Yi
Published: April 2023

Background and Objectives: Postoperative pancreatic fistula (POPF) contributes to significant morbidity and mortality after pancreaticoduodenectomy (PD). However, the underlying mechanisms of POPF remain unclear. This study is to explore the pathology in the pancreatic stump and elucidates the mechanisms of POPF following PD.
Methods: Pathological analysis and 16S rRNA gene sequencing were performed on the specimens obtained from the two patients who accepted complete pancreatectomy for grade C POPF after PD. In addition, a retrospective radiological analysis was conducted on a cohort of 125 consecutive patients who underwent PD to evaluate the inflammatory response in the pancreatic stump.
Results: The presence of gradient inflammation and acinar-duct metaplasia (ADM) in the pancreatic stumps is ubiquitous. The incidence of apoptosis is markedly reduced in the pancreatic stump. Moreover, a significant accumulation of neutrophil-dominated inflammatory cells is detected in the ductal system. Notably, the ADM-formed duct is the site where the neutrophils transmigrate through the ductal wall. Additionally, the microbial evidence indicates that gut microbes migrate from the digestive tract. Radiological analysis proves that a gradient of pancreatitis exists in all cases after PD and reaches peak on the fourth postoperative day.
Conclusions: Inflammation and digestive reflux exist in the pancreatic stump after PD. The underlying mechanisms of POPF are the high biochemical activity of the pancreas, mechanical injury, and digestive reflux.
The comprehensive bioinformatic analysis of the hsa-miR-3613-5p in kidney renal clear cell carcinoma
Authors: Ahmadi Mohsen , Ghaderian Sayyed Mohammad Hossein , Morshedzadeh Firouzeh , Najari-Hanjani Parisa , Ghaffarnia Roya , Kenzerkie Maryam Eftekhari , Mousavi Pegah , Ghafouri-Fard Soudeh
Published: April 2023

microRNA-3613 (hsa-miR-3613-5p), a biomarker with a dual role, oncogenic or tumor suppressor, is associated with different types of cancers. This study aimed to assess the correlation between the hsa-miR-3613-5p gene expression and Kidney renal clear cell carcinoma (KIRC). Using several bioinformatics tools, we examined the expression level and clinicopathological value of hsa-miR-3613-5p in patients with KIRC compared to normal tissues. Other metrics include survival analysis, diagnostic merit of hsa-miR-3613-5p, downstream target prediction, potential upstream lncRNAs, network construction, and functional enrichment analysis hsa-miR-3613-5p, were performed. We observed that overexpression of hsa-miR-3613-5p in KIRC tissues had valuable diagnostic merit and significantly was correlated with the poor overall survival of KIRC patients. We also realized a correlation between abnormal expression hsa-miR-3613-5p and several clinical parameters such as pathological stage, race, age, and histological grades of patients with KIRC. Moreover, we identified the most potential regulatory of hsa-miR-3613-5p in KIRC with 17 different axes, including four pseudogenes, two lncRNAs, and three mRNAs. Besides, we discovered six variants in mature miRNA of hsa-miR-3613-5p. Finally, pathway enrichment analysis uncovered that top-ranked pathways for hsa-miR-3613-5p are cell cycle, cell adhesion molecules (CAMs), and hepatocellular carcinoma pathways. The present report demonstrated that the higher expression of hsa-miR-3613-5p is associated with the progression of KIRC, therefore. It may be considered a valuable indicator for the early detection, risk stratification, and targeted treatment of patients with KIRC.
Nutrition Sensitivity of Smallholder Agricultural Production in Northwest Ethiopia
Authors: Agitew Genanew , Berhanie Zewdu , Gebremedhin Samson
Published: April 2023

Background
Nutrition-sensitive agriculture is a production approach to the ensure production of a variety of affordable, nutritious, culturally appropriate, and safe foods in adequate quantity and quality to meet dietary requirements. The objective of the study was to assess the nutrition sensitivity of smallholder agriculture.
Methods
The study was conducted in four districts of northwest Ethiopia. Data were generated from 748 randomly sampled households using a structured questionnaire-based survey. The analysis was performed using the production diversity score and Simpson’s Diversity Index of food groups produced. A multiple linear regression model was employed to identify factors affecting the production of diversified food groups.
Results
The study revealed that smallholder households on average produce 6.08 food groups out of 12. The production diversity index of smallholder food production is also found to be 88.6%. Multiple linear regression analysis results, on the other hand, shows that the sex of the household head, year of schooling, farming experience, number of oxen, contact with agricultural extension worker, irrigation use, and availability of animal feed are statistical significant factors positively affecting on-farm production diversity of smallholders. Conversely, the age of the household head negatively affected production diversity.
Concluding Remarks:
The study concludes that smallholder agricultural production in northwest Ethiopia is nutrition-sensitive and can supply minimum dietary diversity to households. Promoting small-scale irrigation schemes and strengthening nutrition-sensitive agricultural extension services could contribute to food and nutrition security.
Spectral theorems for Wigner transform associated with the Laguerre-Bessel localization operators
Authors: Chana Ahmed , Akhlidj Abdellatif
Published: April 2023

The main crux of this work is to study the Wigner transform associated with the Laguerre-Bessel operator and to give some results related to this transform. Next motivated by Wong's point of view we define a class of pseudo-differential operator Lu,v (σ) called localization operator wich depend on a symbol σ and two functions u and v, we give a criteria in terms of the symbol σ for its boundedness and compactness, we also show that these operators belongs to the Schatten-Von Neumann class S p for all p ∈ [1; + ∞] and we give a trace formula.
MSC2020-Mathematics Subject Classification: 42B10, 47G30, 47B10.
Pengembangan Model Arsitektural Virtual Expo sebagai Media Alternatif Pembelajaran Kewirausahaan
Authors: Cininta Mutiara , Wibisono Yohanes Priadi
Published: April 2023

Title: Development of Virtual Expo Architectural Model as an Alternative Media for Entrepreneurship Learning
 
Participating in an exhibition plays a vital role in the learning process of entrepreneurship. Exhibitions can be a means to practice selling and introducing products or services, exploring competitor activities, dialogue and demonstrations with potential buyers, and establishing networks with distributors and investors. During the pandemic, there were limited exhibitions due to physical distancing. Although technological developments have made virtual expos possible, MSME players often need help to keep up with the ever-growing digital transformation. Therefore, entrepreneurship education should integrate digital literacy competencies to increase future generations' resilience. This research uses the Research and Development (R&D) method with the ADDIE (Analyze, Design, Development, Implementation, Evaluate) development model. This study proposes a virtual expo model developed using SketchUp, Enscape, and Blender. Virtual Expo as a learning medium has feature criteria that allow participants to practice basic skills in entrepreneurship, including the ability to do promotions (pitching), formulate branding and marketing strategies, make prototypes, and present business plans. The metaverse-based prototype is more recommended for entrepreneurial learning media because it can facilitate real-time interactions such as presentations with visible cameras and gestures, booth designs displayed with three-dimensional models, and more interactive product presentations.
Técnicas didácticas aplicadas a la formación del contador público
Authors:   Universidad Católica Luis Amigó, Ramírez Tapias Diego , Chamorro González Candy ,   Universidad Católica Luis Amigó, Rodelo Sehuanes Mario ,   Universidad del Atlántico, Vásquez Montoya Olga ,   Universidad Católica Luis Amigó, Velásquez Pérez Mariela , Bustos Sierra Sergio Esteban ,   Universidad Nacional de Colombia, Garavito Robayo Gabriel David
Published: April 2023

Este libro presenta aproximaciones teóricas y experiencias laborales de los docentes del programa de Contaduría Pública de la Universidad Católica Luis Amigó, respecto a las técnicas didácticas proyectadas y aplicadas en su arte de enseñar en contabilidad. El primer acápite esboza una breve introducción contextual de la didáctica a partir de su historicidad. Seguidamente, se determinan las estrategias y técnicas didácticas utilizadas en el proceso de enseñanza-aprendizaje del profesional contable. El tercer apartado revela las técnicas didácticas utilizadas para la formación contable y, finalmente, el capítulo cuatro profundiza en otras técnicas didácticas a partir de la práctica pedagógica salida de campo. De esta manera, el presente texto académico tiene la intención de generar debate entre la comunidad contable.
ATTITUDES AND IMPRESSIONS OF UPPER PRIMARY TEACHERS IN THE REPUBLIC OF CROATIA ABOUT ONLINE TEACHING DURING THE COVID-19 PANDEMIC – HOW DID WE DO IT?
Authors:   Faculty of Educational science, University “Juraj Dobrila”, Pula, Croatia, Kadum S. , Ruzic-Baf M. , Brozovic L
Published: April 2023

The transition to online teaching during the COVID-19 pandemic included almost all teachers and students. Digital (inadequate) skills and (in)competencies of both teachers and students have come to the fore. Accelerated adaptation, getting used to new forms of work, learning and teaching in these two years has introduced significant changes in the educational process and has shown the need to revise the educational system and the need for modernization and transformation. The study presents the results of a survey of a sample of 1,600 upper primary teachers in primary schools in the Republic of Croatia, which aimed to examine their attitudes and impressions regarding the implementation of online teaching during the pandemic COVID-19. The results of the research showed the following: The vast majority of respondents (94.1%) answered that the classic form of teaching is better than online teaching. Most of the respondents spent 2 to 4 hours in the preparation and evaluation of student materials.
TRAINING OF FUTURE EDUCATORS TO WORK WITH PARENTS AND THEIR ROLE IN THE AREA OF PARTNERSHIP BETWEEN THE EDUCATIONAL INSTITUTION AND FAMILY
Authors:   Faculty of Philosophy, University of Tuzla, Bosnia and Herzegovina, Mujic Senada
Published: April 2023

The main goal of this research was to determine whether and to what extent educational programs and curriculums for preschool education develop competences in students that are needed for establishing partnership with parents. The basic research technique is the analysis of syllabus documentation. The analysis was created for the preschool education educational programs in the Federation of Bosnia and Herzegovina (University in Tuzla, University in Zenica, University in Bihac, University in Sarajevo), and it showed that there are differences between institutions in the aspect of presence of study courses that prepare future educators for the work with parents. The results of the research have shown that there are differences in relation to the examined units of analysis and that the degree of conformity of syllabus contents for the course subject Family Pedagogy and Partnerships with parents varies in relation to the examined areas.
READING OF BLIND STUDENTS
Authors:   Faculty of Education and Rehabilitation, University of Tuzla, Bosnia and Herzegovina, Tulumovic Sevala , Bacic-Mujagic Aida ,   Centre for Blind and Visually Impaired Children Nedzarici - Sarajevo
Published: April 2023

The aim of the research was to determine the success of reading Braille graphemes and understanding the read text in congenitally blind students. The research included 61 students: 30 congenitally blind students, 31 students who went blind later in life, aged 7-18, both genders who are in education and rehabilitation in the Centre for Blind and Visually Impaired Children and Youth Nedzarici in Sarajevo and in elementary schools in Tuzla Canton and Brcko District. The obtained results showed that there is no statistically significant difference in the ability to read Braille graphemes, and a statistically significant difference was shown in the understanding of the read text in Braille between congenitally blind students and students who went blind later in life.
EFFECT OF ANIMAL-ASSISTED THERAPY ON DEPRESSION, MEMORY, ATTENTION, AND EMOTION REGULATION
Authors:   Department of Psychology, Christ University, Bangalore, India, G Hunjan Unnati , Reddy K. Jayasankara ,   Department of Psychology, Christ University, Bangalore, India
Published: April 2023

Introduction: The mere presence of a dog in a therapeutic setup is known to bring about more positive outcomes when incorporated in therapy, dogs can bring about multifarious benefits which are not entirely tapped upon. Aim: This research aimed to study the effect of animal-assisted therapy (AAT), with therapy dogs, on depressive symptoms, emotional regulation, memory and attention of individuals. Method: A pretest-posttest quasi-experimental research design was used. Psychology Experiment Building Language (PEBL) for memory and attention, Difficulty in Emotion Regulation Scale (DERS) and Hamilton Depression Rating Scale (HDRS) were used for pre and post-testing 1 week before and post the intervention. Results: The findings reveal a positive impact of AAT on the given domains of memory, attention, emotion regulation and depressive symptoms, in the experimental group. No significant changes were obtained for the control group. Discussion: The results help validate the module of AAT to improve an individual’s cognitive functioning and alleviate depressive and emotional dysregulations. Further implications are discussed.
Assessment of the sensitivity of water resources in the intertropical zone: a bibliographical study with perspectives
Authors: Mba Franck Fabrice , Temgoua Emile , Djousse Kanouo Boris Merlain , Tontsa Lauric , Wowinwo Ramces Takoubo , Kamhoua Cerge Natheu
Published: April 2023

Study of the vulnerability of water resources contributing to consumer health in the inter-tropical zone. The aim of this paper is to present the state of the art on the protection of water resources in the inter-tropical zone in order to identify gabs in knowledge that improve drinking water supply. To achieve this, a documentary search online was carried out to assess the progression of work over time. What emerges from this literature review is that the method for assessing intrinsic and specific vulnerability in bedrock areas is practically non-existent. A discrepancy exists and reflects the difference in a coincidence of the level of vulnerability when several methods of determining vulnerability are used in the same study site. The issue of validation is still problematic, as it lies in the fact that a property that is not precisely defined cannot be unambiguously deduced from the measured quantity. The characterisation of specific pollutants and their propagation in the saturated or groundwater zone are not taken into account. All the different components of the water cycle are not always taken into account during a groundwater vulnerability study, yet each water resource is part of a closely related component of the water cycle.
Characterization of granite mining waste for geotechnical purposes
Authors: Batista Albert Jonatha , Ingunza Maria Del Pilar Durante
Published: April 2023

Waste generation is part of any production process. Among productive sectors, the mining industry stands out in environmentally sustainable models due to the large volume of waste produced. Crystalline rocks, particularly granites, are highlighted due to their high mechanical strength and esthetic characteristics. The aim of this study was to perform a geological/geotechnical characterization of granite mining waste for geotechnical purposes. Samples of granite mining waste were collected at different waste disposal points. The following characterizations were performed: physical (apparent specific gravity, apparent absorption and apparent porosity), optical and scanning electron microscopy and mechanical characterization (uniaxial compressive strength test). All the samples analyzed exhibited physical indices and average values compatible with those recommended by international standards. Textural aspects, such as random muscovite concentration, forming aggregates, can explain the mechanical behaviour of the samples. In addition, based on the results obtained, the waste collected can be used in the riprap of hydraulic and construction projects that cross water courses and roadways.
Nonsynonymous Synonymous Variants Demand for a Paradigm Shift in
Genetics
Authors: Vihinen Mauno
Published: April 2023

Synonymous (also known as silent) variations are by definition not considered to change
the coded protein. Still many variations in this category affect either protein abundance or properties.
As this situation is confusing, we have recently introduced systematics for synonymous variations and
those that may on the surface look like synonymous, but these may affect the coded protein in various
ways. A new category, unsense variation, was introduced to describe variants that do not introduce a
stop codon into the variation site, but which lead to different types of changes in the coded protein.
Many of these variations lead to mRNA degradation and missing protein. Here, consequences of the
systematics are discussed from the perspectives of variation annotation and interpretation, evolutionary
calculations, nonsynonymous-to-synonymous substitution rates, phylogenetics and other evolutionary
inferences that are based on the principle of (nearly) neutral synonymous variations. It may be
necessary to reassess published results. Further, databases for synonymous variations and prediction
methods for such variations should consider unsense variations. Thus, there is a need to evaluate and
reflect principles of numerous aspects in genetics, ranging from variation naming and classification to
evolutionary calculations.
Increased Prevalence of Gastroesophageal Reflux Disease Among Patients
With Rheumatoid Arthritis: A Systematic Review and Meta-analysis
Authors: Thongpiya Jerapas , Charoenngam Nipith , Ponvilawan Ben , Yingchoncharoen Pitchaporn , Jaroenlapnopparat Aunchalee , Ungprasert Patompong
Published: April 2023

Objective:

This study was conducted to determine the association between gastroesopha-geal reflux disease (GERD) and rheumatoid arthritis (RA) by pooling the evidence from all availa-ble studies.

Methods:

Potentially eligible studies were identified from MEDLINE and EMBASE database from inception to April 2021 employing a search strategy that consisted of terms for “Rheumatoid Arthri-tis” and “Gastroesophageal Reflux Disease”. Eligible studies for the meta-analysis were recruited with conditions of being cohort studies that included rheumatoid arthritis and without rheumatoid arthritis individuals. Together with this, prevalence of GERD in both groups and the odds ratio (OR) comparing the prevalence of GERD between the two cohorts have been reported. The re-trieved point estimates with standard errors from each study were pooled into the final result by the random-effect model and generic inverse variance method as described by DerSimonian and Laird.

Results:

A total of 3,646 articles were identified. After two rounds of independent review by two investigators, five cohort studies were included in the meta-analysis as they met the eligibility crite-ria. The pooled analysis demonstrated a significant association between RA and GERD with the pooled odds ratio of 1.98 (95% CI, 1.49 - 2.65). High statistical heterogeneity with I2 of 83% was observed. The funnel plot was symmetric and publication bias was not observed.

Conclusion:

This systematic review and meta-analysis found a significant association between GERD and RA.
Recurrent Plunging Ranula – A Rare Case Report
Authors: Bharti Jyotsna Naresh , Nigam Jitendra Singh
Published: April 2023

Background:

Plunging ranula is a variant of ranula, which present as a painless subcutaneous anterolateral neck mass and is located beyond the mylohyoid
muscle. Plunging ranula is a diagnostic challenge and can present with intraoral component.

Case Report:

An elderly male presented with painless neck mass in the cervical region for three months. The mass was excised, and the patient is doing well on
follow-up. We report a case of recurrent plunging ranula without any intraoral component.

Conclusion:

Whenever the intraoral component is missing in ranula, chances of misdiagnosis and mismanagement are high. Awareness of this entity and high
index of suspicion is needed for accurate diagnosis and effective management.
Screening of Inhibitors against Idiopathic Pulmonary Fibrosis: Few-shot
Machine Learning and Molecule Docking based Drug Repurposing
Authors: Chang Jun , Zou Shaoqing , Xu Subo , Xiao Yiwen , Zhu Du
Published: April 2023

Introduction:

Idiopathic pulmonary fibrosis is a chronic progressive disorder and is
diagnosed as post-COVID fibrosis. Idiopathic pulmonary fibrosis has no effective treatment because
of the low therapeutic effects and side effects of currently available drugs.

Aim:

The aim is to screen new inhibitors against idiopathic pulmonary fibrosis from traditional
Chinese medicines.

Methods:

Few-shot-based machine learning and molecule docking were used to predict the potential
activities of candidates and calculate the ligand-receptor interactions. In vitro A549 cell model
was taken to verify the effects of the selected leads on idiopathic pulmonary fibrosis.

Results:

A logistic regression classifier model with an accuracy of 0.82 was built and, combined
with molecule docking, used to predict the activities of candidates. 6 leads were finally screened
out and 5 of them were in vitro experimentally verified as effective inhibitors against idiopathic
pulmonary fibrosis.

Conclusion:

Herbacetin, morusin, swertiamarin, vicenin-2, and vitexin were active inhibitors
against idiopathic pulmonary fibrosis. Swertiamarin exhibited the highest anti-idiopathic pulmonary
fibrosis effect and should be further in vivo investigated for its activity.
A Systematic Review on Pesticide-loaded Nanocapsules: A Sustainable
Route for Pesticide Management to Enhance Crop Productivity
Authors: Kumar Sumit , Bhuvaneshwari R , Jain Sejal , Nirwan Shweta , Fatima Zainab , Kumar Dharmender , Chhikara Bhupendra S. , Rathi Brijesh , Poonam
Published: April 2023

Synthetic pesticides, crucial compounds for agricultural production, degrade quickly and
damage the environment, hence solutions for their decreased usage or formulations with prolonged
efficacy at low dosages are needed. Nanotechnology for nanosized formulations may reduce pesticide
adverse effects. Nano-encapsulated pesticides made from nanocapsules, nanoemulsions, micelles,
and nanogels outperform traditional pesticides with minimum environmental impact. Nanopesticides
allowed target-based administration to decrease leaching and drainage into water bodies,
and lower pesticide active component dosages. Nanocapsules with a core-shell configuration
and a pesticide in the core are the most advantageous nanomaterials. Nanocapsules shield the active
component. Stimuli-responsive nanocapsules may limit pesticide release by responding to pH, temperature,
light, enzyme, or redox reactions. Toxicity prevents their use. This review discusses the
latest developments in nanocapsule fabrication methods, their relevance, contemporary synthetic
approaches to developing pesticide-loaded nanocapsules, and the features of these nanocomposites,
with an emphasis on sustainable agricultural applications.
Recent Progresses on Pathophysiology, Diagnosis, Therapeutic Modalities,
and Management of Non-alcoholic Fatty Liver Disorder
Authors: Barazesh Mahdi , Jalili Sajad , Akhzari Morteza , Faraji Fouzieyeh , Khorramdin Ebrahim
Published: April 2023

Non-alcoholic fatty liver disease (NAFLD) is currently the utmost common chronic liver
disorder that happens through all age groups and is identified to occur in 14%-30% of the general
population, demonstrating a critical and grossing clinical issue because of the growing incidence of
obesity and overweight. From the histological aspect, it looks like alcoholic liver damage, but it happens in patients who avoid remarkable alcohol usage. NAFLD comprises a broad spectrum, ranging
from benign hepatocellular steatosis to inflammatory nonalcoholic steatohepatitis (NASH), different
levels of fibrosis, and cirrhosis. Patients with NASH are more susceptible to more rapid progression to
cirrhosis and hepatocellular carcinoma. There is no single factor that drives proceeding from simple
steatosis to NASH. However, a combination of multi parameters such as genetic background, gut microflora, intake of high fat/ fructose dietary contents or methionine/choline-deficient diet, and consequently accumulated hepatocellular lipids mainly including triglycerides and also other bio-analytes,
such as free fatty acids, cholesterol, and phospholipids display a crucial role in disease promotion.
NAFLD is related to overweight and insulin resistance (IR) and is regarded as the hepatic presentation
of the metabolic syndrome, an amalgamation of medical statuses such as hyperlipidemia, hypertension, type 2 diabetes, and visceral obesity. Despite the increasing prevalence of this disease, which
imposes a remarkable clinical burden, most affected patients remain undiagnosed in a timely manner,
largely related to the asymptomatic entity of NAFLD patients and the unavailability of accurate and
efficient noninvasive diagnostic tests. However, liver biopsy is considered a gold standard for NAFLD
diagnosis, but due to being expensive and invasiveness is inappropriate for periodic disease screening.
Some noninvasive monitoring approaches have been established recently for NAFLD assessment. In
addition to the problem of correct disease course prediction, no effective therapeutic modalities are
approved for disease treatment. Imaging techniques can commonly validate the screening and discrimination of NAFLD; nevertheless, staging the disease needs a liver biopsy. The present therapeutic approaches depend on weight loss, sports activities, and dietary modifications, although different insulin-sensitizing drugs, antioxidants, and therapeutic agents seem hopeful. This review aims to focus on
the current knowledge concerning epidemiology, pathogenesis, and different biochemical experiments
and imaging modalities applied to diagnose the different grades of NAFLD and its management, as
well as new data about pharmacological therapies for this disorder.
Diterpenoid Tanshinone Attenuates the Metastasis of Non-small-cell Lung Cancer
(NSCLC) Cells by Inhibiting the Cavin-1-mediated ERK/Smad2 Signaling Pathway
Authors: Wang Lu , Jiang Gangdan , Li Xiaojuan
Published: April 2023

Background:

Non-small cell lung cancer (NSCLC) is a common malignant cancer with high incidence and
mortality. In recent decade, despite the progress in the treatment and prevention of NSCLC, its prognosis still remains
poor. It is urgently needed to identify new potential mechanism and efficacious drugs for NSCLC patients.

Objective:

The objective of this study is to explore the potential therapeutic role of diterpenoid tanshinone (DT) against
non-small cell lung cancer (NSCLC) in vitro and elucidate the molecular mechanism involved in tumor metastasis.

Methods:

Human NSCLC lines (A549 and NCI-H1299) were transfected with pcDNA3.1-Cavin-1 plasmids and corresponding
controls. We tested the effects of DT on migration and invasion of lung cancer cells using transwell filters
coated with fibronectin and Matrigel. Next, Quantitative Real-Time PCR and western blot were used to determine the
transcriptional and protein levels of epithelial-mesenchymal transition (EMT) markers, transcription factors (Snail,
Slug), and matrix metalloproteinases.

Results:

As expected, Cavin-1 related to the enhanced ability of cell migration and invasion. DT not only inhibited the
migratory and invasive capacity of Cavin-1-transfected NSCLC cells but also significantly increased the expression of
ZEB1 and E-cadherin and decreased the level of N-cadherin, Vimentin, Snail, and Slug. Moreover, DT treatment obviously
alleviated Cavin-1 overexpression-induced high levels of MMP2, MMP7, and MMP9 at both the protein and
transcriptional levels. Furthermore, overexpressed Cavin-1 upregulated ERK and Smad2 signaling pathways in
NSCLC cells, which were also strongly weakened by DT administration.

Conclusion:

Our results suggested that DT effectively attenuates Cavin-1-mediated NSCLC metastasis via the
ERK/Smad2 signaling pathway.
Post-Exposure Prophylaxis for COVID-19: A Systematic Review
Authors: SeyedAlinaghi SeyedAhmad , Karimi Amirali , Pashaei Zahra , Shobeiri Parnian , Janfaza Nazanin , Behnezhad Farzane , Ghasemzadeh Afsaneh , Barzegary Alireza , Arjmand Ghazal , Noroozi Alireza , Shojaei Alireza , Amiri Ava , Vahedi Farzin , Mahalleh Mehrdad , Shamsabadi Ahmadreza , Dashti Mohsen , Afsahi Amir Masoud , Mehraeen Esmaeil , Dadras Omid
Published: April 2023

Introduction:

SARS-CoV-2 cause pneumonia can spread across the lung and lead to acute
respiratory distress syndrome (ARDS) in severe cases. Post-exposure prophylaxis has shown great
potential to prevent the transmission of some viral infections; however, such results for COVID-19 are
still inconclusive.

Methods:

Therefore, the aim of this study was to systematically review the resources that utilized postexposure
prophylaxis (PEP) for COVID-19 and the possible clinical benefits of such drugs. An organized
search of relevant literature was done using the keywords and search queries on public databases
of Cochrane, PubMed, Web of Science and Scopus from December 2019 to August 23, 2021. Original
resources that had the inclusion criteria were included after two-phase title/abstract and full-text
screenings. This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-
Analysis (PRISMA) statement.

Results:

Out of 841 retrieved records 17 resources were appropriate to include in the systematic review.
Hydroxychloroquine with a daily dose of 400-800 mg and a duration of 5-14 days was the most
frequently used agent for PEP. Chloroquine was recommended to use to control treatment in patients
with mild to severe COVID-19 pneumonia. Other agents like Lopinavir-ritonavir (LPV/r), angiotensinconverting
enzyme inhibitors (ACEIs), Angiotensin receptor blockers (ARBs), Vitamin D, arbidol,
thymosin drugs, and Xin guan no.1 (XG.1, a Chinese formula medicine) have also been applied in
some studies.

Conclusion:

Current evidence demonstrated no established clinical benefits of any drug as PEP in
individuals with COVID-19. However, scarce indication occurs for the beneficial effects of some
agents, but more studies are needed to explore such effects.
How the information asymmetry determine firm value?
Authors: Santra I Ketut , Wirga I Wayan , Sanjaya Ida Bagus , Yasa I Ketut , Waelan Waelan
Published: April 2023

Firm value is the price that prospective buyers are willing to pay if the company is sold. The purpose of this study is to determine the effect of information asymmetry on firm value. The population of this study are all Property and Real Estate Sector Companies listed on the Indonesia Stock Exchange for the 2020-2022 period, namely 40 companies. The samples used were 120 samples. The sampling technique used purposive sampling technique. The data used is secondary data, namely the company's financial statements. Data analysis in this study is multiple regression analysis. The results of the study show that information asymmetry has no effect on firm value.
Analisis jenis dan fungsi kalimat dalam interaksi komunikasi keluarga Amalgamasi YouTuber Dewi Pobo
Authors: Nurbaya St
Published: April 2023

Penelitian ini bertujuan mendeskripsikan  jenis dan fungsi pemakaian kalimat yang   dalam peristiwa komunikasi youtuber keluarga amalgamasi Dewi Pobo. Rumusan masalah yang diajukan adalah “ Apa saja jenis dan manfaat kalimat yang terdapat dalam interaksi komunikasi keluarga amalgamasi youtuber Dewi Pobo? Pendekatan penelitian yang digunakan adalah pendekatan penelitian kualitatif dengan jenis  penelitian analisis konten. Metode pengumpulan data menggunakan teknik metode simak dengan teknik simak bebas libat catat. Analisis data yang digunakan adalah deskriptif kualitatif.Hasil penelitian ditemukan  empat jenis kalimat yang digunakan yakni; kalimat deklaratif, kalimat imperative, kalimat introgatif dan kalimat ekslamatif. Kalimat-kalimat tersebut difungsikan sesuai konteks komunikasi yang terjadi.This study aims to describe the types and functions of the use of sentences in the communication events of the amalgamation family YouTuber Dewi Pobo. The research question posed was "What are the types and benefits of sentences contained in the communication interaction of the amalgamation family of YouTuber Dewi Pobo?" A qualitative research approach with content analysis was used for the research. The data collection method employed the observation technique with the note-free observation technique. The data analysis used was descriptive qualitative. The results of the study identified four types of sentences: declarative, imperative, interrogative, and exclamatory.  These sentences function according to the context of the communication that occurs in the amalgamation family.
The impact of strengthening fiqh learning in the department of islamic education through integrating health sciences
Authors: Nurkhamidi Aris , Khuzaiyah Siti , Widodo Syukri Fathuddin Ahmad
Published: April 2023

Students majoring in Islamic Education at the Faculty of Tarbiyah and Teacher Training are expected to be competent in understanding and teaching Islamic Religious Education subjects in schools. Among the Islamic Religious Education materials in schools is the Fiqh of worship. Based on field studies, religious fiqh lectures are carried out with a pure fiqh approach. Fiqh lectures have not been integrated with other relevant sciences and disciplines, such as health sciences. This research and development (RD) aimed to examine the impact of integrated learning between Fiqh and health science on the students. This study was research and development combining the concept of religious fiqh lectures with the health sciences aspect. The respondents were students in the Faculty of Tarbiyah and Teacher Training.  The results showed that integrating Fiqh and Health sciences has positive impacts, namely: (1) increasing student motivation and attention in lectures, (2) increasing mastery of fiqh material from the point of view of health sciences, and (3) improving the readiness of students in pursuing the profession of Islamic religious educators in schools. Three methods that could possibly implement the design of strengthening Fiqh learning with health sciences were (1) Lectures with a single lecturer, (2) lectures with team teaching lecturers, and (3) lectures with additional classes specifically for health sciences (Special session). Integrating fiqh subjects with health sciences could be taken into account, as it might benefit the student's competence in mastering fiqh science on a broader view.
Wilhelm Dilthey's hermeneutics and its relevance to Islamic studies
Authors: Murdiati Dwi , Mukalam Mukalam
Published: April 2023

This study aimed to describe William Dilthey's hermeneutics and show its relevance to the study of Islamic history. This research is interesting to do when looking at the relationship between hermeneutics and Islamic studies, in the mainstream, it is in normative Islamic studies.  This study used descriptive analytical methods to describe the ins and outs of Dilthey's hermeneutics and the relevance of this hermeneutic in Islamic studies. The results showed that historical Islamic studies can utilize three elements in Dilthey's hermeneutics, namely Erlebnis (world of inner experience), Ausdruck (expression of life) and Verstehen (understanding). In addition, historical Islamic studies can also take advantages of the three conditions in Dilthey's hermeneutics, namely descriptive psychology, hermeneutical circles and socio-cultural knowledge.
Good Corporate Governance dan Corporate Social Responsibility di Indonesia: Pentingkah Earnings Response Coefficient?
Authors: Sujarwati Rianita , Khoirunisa Ikasari , Firmansyah Amrie
Published: April 2023

Abstrak: Good Corporate Governance dan Corporate Social Responsibility di Indonesia: Pentingkah Earnings Response Coefficient? Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh Good Corporate Governance (GCG) dan pengungkapan Corporate Social Responsibility (CSR) terhadap Earnings Response Coefficient (ERC) pada perusahaan subsektor perbankan yang terdaftar di BEI periode 2017—2019Data dianalisis dengan metode uji regresi linear berganda untuk data panel. Hasil uji menunjukkan Good Corporate Governance (GCG) berpengaruh positif signifikan terhadap Earnings Response Coefficient (ERC), sedangkan Corporate Social Responsibility (CSR) tidak berpengaruh terhadap Earnings Response Coefficient (ERC). Penelitian ini memberikan gambaran dan informasi terkait kualitas laba perusahaan perbankan yang ditunjukkan dari reaksi investor terhadap pengungkapan good corporate governance dan corporate social responsibility. Berbeda dengan penelitian sebelumnya, penelitian ini menilai pengungkapan Good Corporate Governance (GCG) menggunakan indikator Surat Edaran OJK Nomor 13/SEOJK.03/2017 tentang Penerapan Tata Kelola Bagi Bank Umum.Kata kunci: corporate social responsibility, earnings response coefficient, good corporate governance, unexpected earningsAbstract: Good Corporate Governance and Corporate Social Responsibility in Indonesia: Is the Earnings Response Coefficient Important? This study aims to examine and analyze the effect of Good Corporate Governance (GCG) and disclosure of Corporate Social Responsibility (CSR) on the Earnings Response Coefficient (ERC). This study uses secondary data from banking sub-sector companies listed on the Indonesia Stock Exchange during 2017-2019. The data were analyzed using the multiple linear regression test method for panel data. The test results indicate that Good Corporate Governance (GCG) has significant positive effect on the Earnings Response Coefficient (ERC), while the Corporate Social Responsibility (CSR) does not affect the Earnings Response Coefficient (ERC). This study provides an overview and information related to the earnings quality of banking companies as indicated by investor reactions to the disclosure of GCG and CSR. In contrast to previous research, this study assesses the disclosure of Good Corporate Governance (GCG) using the indicators of the Circular Letter of The Financial Services Authority Number 13/SEOJK.03/2017 concerning the Application of Good Corporate Governance for Commercial Banks. Keywords: corporate social responsibility, earnings response coefficient, good corporate governance, unexpected earnings
Rupiah Exchange Rate Fluctuations in The US Dollar, Purchasing Power Parity Theory and Fisher Effect Theory Testing
Authors: Pangestuti Dewi Cahyani , Fadila Ardhiani , Nugraheni Siwi
Published: April 2023

Abstract: Rupiah Exchange Rate Fluctuations in The US Dollar, Purchasing Power Parity Theory and Fisher Effect Theory Testing.  To test the accuracy of the power purchasing parity theory and the international fisher effect theory on fluctuations in the Rupiah exchange rate against the United States Dollar. The goal of this study is to examine if the power purchasing parity theory and the international fisher effect theory are valid when it comes to Rupiah-US Dollar exchange rate movements. The purpose of this research is to figure out the rate of inflation, interest rate, and movement of the rupiah against the US dollar. This research examined historical data on the rupiah exchange rate against the US dollar, interest rates, and inflation rates in Indonesia and the United States from January 2015 through December 2020. In this research, multiple linear regression analysis was used. Research proved that the theory of power purchasing parity applies to changes in the Indonesian rupiah exchange rate on the US dollar. The international fisher effect does not apply to changes in the Indonesian Rupiah currency rate against the US dollar, which proves the existence of theoretical deviations that result in the invalidity of this theory.Keywords: purchasing power parity, international fisher effect, exchange rateAbstrak: Fluktuasi Nilai Tukar Rupiah dalam Dollar US, Pengujian Teori Paritas Daya Beli dan Teori Fisher Efek. Tujuan dari penelitian ini adalah untuk menguji keakuratan volatilitas nilai tukar rupiah terhadap dolar AS dalam teori paritas daya beli (PPP) dan teori dampak fisher internasional. Variabel dalam penelitian ini adalah inflasi, suku bunga, dan pergerakan nilai tukar rupiah terhadap dolar AS. Data yang digunakan dalam penelitian adalah data historis nilai tukar Rupiah terhadap dolar Amerika Serikat dan tingkat suku bunga Indonesia dan Amerika Serikat serta tingkat inflasi dari bulan Januari 2015 sampai dengan Desember 2020. Metode dalam penelitian adalah: Analisis regresi linier berganda. Penelitian membuktikan bahwa teori power purchasing parity berlaku pada perubahan kurs mata uang Rupiah Indonesia pada Dollar Amerika Serikat.  Teori internasional fisher effect tidak berlaku berlaku pada perubahan kurs mata uang Rupiah Indonesia pada Dollar Amerika Serikat, yang membuktikan adanya penyimpangan teori yang mengakibatkan tidak berlakunya teori ini.Kata kunci: paritas daya beli, internasional efek fisher, perubahan kurs
Analisis Faktor Adopsi E-Wallet Gopay, OVO, dan DANA dengan Model UTAUT2 pada Masyarakat Jawa Barat
Authors: Saragih Yulia Wahyuni , Rikumahu Brady
Published: April 2023

Analysis of the Gopay, OVO, and DANA E-Wallet Adoption Factors with the UTAUT2 Model in the West Java. Fintech is changing the banking industry, reshaping business, and changing the way consumers manage and use money. This study's purpose is to examine the factors that affect the adoption of e-wallet, a product of fintech in West Java using the UTAUT 2 model. This study used data collection techniques in the form of surveys by distributing online and manual questionnaires. The respondents of this research are 400 users from Gopay, OVO, or DANA, domiciled in West Java, and ranging in age from 18-40 years. This study used the PLS-SEM model. The results showed that there were three accepted hypotheses. Only the Habit variable (H7a) has a positive significant effect on the Behavioral Intention, while the other variables have no significant effect. Also, it was found that the variables of Facilitating Conditions (H4b) and Behavioral Intention (H8) had a significant positive effect on Use Behavior. In addition, only the Gender variable moderates the independent variable with the dependent variable. ABSTRAKAnalisis Faktor Adopsi E-wallet Gopay, OVO, dan DANA dengan Model UTAUT2 pada Masyarakat Jawa Barat. Fintech telah mengubah industri perbankan, membentuk kembali bisnis, dan mengubah cara konsumen mengatur dan menggunakan uang mereka. Tujuan dari penelitian ini yaitu untuk meneliti faktor-faktor yang mempengaruhi adopsi e-wallet yang merupakan produk dari fintech pada masyarakat Jawa Barat menggunakan model UTAUT 2. Penelitian ini menggunakan teknik pengambilan data berupa survei dengan menyebarkan kuesioner secara online dan manual. Responden penelitian ini merupakan 400 pengguna dari Gopay, OVO, atau DANA, berdomisili di Jawa Barat, dan berusia 18-40 tahun. Penelitian ini akan menggunakan model PLS-SEM. Hasil penelitian menunjukkan bahwa terdapat tiga hipotesis yang diterima. Hanya variabel Kebiasaan (H7a) yang berpengaruh signifikan positif dengan niat menggunakan, sedangkan variabel lainnya tidak berpengaruh signifikan. Kemudian ditemukan bahwa variabel Kondisi Pendukung (H4b) dan Niat Menggunakan (H8) berpengaruh signifikan positif dengan perilaku menggunakan. Kemudian, hanya variabel jenis kelamin yang memoderasi variabel independen dengan variabel dependen.
Pandemi Covid 19: Peran Good Corporate Governance terhadap Kinerja Perbankan
Authors: Gozali Efva Octavina Donata , Hamzah Ruth Samantha , Pratiwi Chomsah Novianti
Published: April 2023

Abstrak: Pandemi Covid 19: Peran Good Corporate Governance terhadap Kinerja Perbankan. Penelitian ini bertujuan untuk menganalisis pengaruh good corporate governance (GCG) terhadap kinerja keuangan sektor perbankan yang diproksikan dengan return on assets (ROA) dan return on equity (ROE) pada saat wabah Covid 19 merebak di tahun 2020. GCG diproksikan dengan kepemilikan manajerial, kepemilikan institusional, komite audit dan komisaris independen. Sampel penelitian ini terdiri dari 30 perusahaan perbankan yang seluruhnya terdiri dari perbankan konvensional. Data diperoleh dari data sekunder berupa laporan keuangan tahunan yang diakses melalui database resmi Bursa Efek Indonesia (BEI) dengan periode pengamatan di tahun 2020, sehingga data yang diobservasi merupakan data cross section. Metode sampling yang digunakan adalah purposive sampling dan data diolah menggunakan analisis regresi berganda. Hasil penelitian menunjukkan bahwa proksi dari GCG yaitu kepemilikan manajerial, kepemilikan institusional, komite audit dan komisaris independen secara tidak berpengaruh signifikan terhadap ROA maupun ROE. Hasil ini memberi arti bahwa GCG tidak memiliki pengaruh signifikan terhadap kinerja keuangan perbankan pada masa pandemi Covid 19. Manajemen maupun pemerintah perlu membuat kebijakan yang efektif dan efisien terkait tata kelola perusahaan sektor perbankan dalam mengatasi kemerosotan kinerja yang diakibatkan oleh ketidakpastian ekonomi maupun lingkungan, seperti wabah Covid 19.Kata kunci: Good Corporate Governance, Kinerja Keuangan Perbankan, Pandemi Covid 19, ROA, ROEAbstract: Covid 19 Pandemic: The Role of Good Corporate Governance on Banking Performance. This study aims to investigate the effect of good corporate governance (GCG) on the financial performance of the banking sector which measured by return on assets (ROA) and return on equity (ROE) during the Covid 19 outbreak in 2020. GCG is proxied by managerial ownership, institutional ownership, audit committees and independent commissioners. Further, the data is obtained from the official database of Indonesia Stock Exchange (IDX) which consists of 30 conventional banks as samples. The sampling and analysis method are purposive sampling and cross sectonal-multiple regression, respectively. The results show that all proxies of GCG, namely managerial ownership, institutional ownership, audit committee and independent commissioners partially have no significant effect on ROA and ROE. This result implies that GCG does not have a significant influence on banking financial performance during the Covid 19 pandemic. Management and government have to elaborate effective and efficient policies related to corporate governance in banking industries in regard to overcome financial distress which caused by economic and environmental uncertainties, such as the Covid 19 pandemic.Keywords: Good Corporate Governance, Banking Financial Performance, Covid 19 Pandemic, ROA, ROE