bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Konsentrasi Letal Dan Waktu Letal Isolat Jamur Aspergillus Niger Terhadap Nyamuk Aedes Aegypti
Authors: Kadek Sinta Cahyani Ni Diah , Wiadnya Ida Bagus Rai , Khusuma Ari , Getas I Wayan
Published: October 2023

Latar Belakang: Nyamuk Aedes aegypti merupakan penyebab utama penyakit DBD, kasus DBD di dunia pada tahun 2015 sebanyak 3,2 juta kasus. Di Indonesia pada tahun 2018 terdapat 65.602 kasus. Upaya pengendalian terhadap vektor DBD telah banyak dilakukan baik dengan menggunakan insektisida kimia dan alami salah satunya dengan jamur Aspergillus niger sebagai fungi entomopatogen. Tujuan Penelitian: Mengetahui konsentrasi letal dan waktu letal dari isolat jamur Aspergillus niger terhadap nyamuk Aedes aegypti.  Metode Penelitian: Penelitian ini merupakan penelitian true eksperimental dengan rancangan acak lengkap. Perlakuan dengan 3 konsentrasi isolat jamur Aspergillus niger yaitu 10-5, 10-6, 10-7 spora/ml dengan 6 replikasi. Penelitian ini menggunakan obat nyamuk semprot sebagai kontrol positif. Data diperoleh dianalisa secara statistik menggunakan analisis probit. Hasil Penelitian: Konsentrasi isolat jamur Aspergillus niger yang efektif terhadap nyamuk Aedes aegypti adalah konsentrasi 10-7. Hasil analisis probit uji patogenitas isolat jamur Aspergillus niger terhadap nyamuk Aedes aegypti dengan tingkat kepercayaan 95% didapatkan LC50, LC70, LC90 adalah 6,1 x 107 spora/ml, 8,5 x 107 spora/ml, 1,1 x 108 spora/ml dan diketahui LT50, LT70, LT90 berturut-turut adalah 1,919 jam, 1,510 jam, 1,184 jam. Kesimpulan: Konsentrasi isolat jamur Aspergillus niger secara signifikan memberikan pengaruh terhadap kematian nyamuk Aedes aegypti.
Human Immunodefiency Virus Infection in Tuberculosis Patients at Kotaraja Health Center of Papua
Authors: Sinaga Herlando , Rampa Ester , Woriori Anni Erna
Published: October 2023

Human Immunodeficiency Virus (HIV) is a virus that attacks white blood cells and causes the human immune system to decrease. Tuberculosis in HIV patients is an opportunistic infection that will aggravate the disease infection in patients. Examination of HIV (Human Immunodeficiency Virus) in Tuberculosis Patients was carried out at the Kotaraja Health Center. This study was conducted for 1 month starting from May 17, 2019, to June 07, 2019. The purpose of this study was to determine HIV in tuberculosis patients at the Kotaraja Health Center. This type of research is descriptive with a laboratory test approach. The sample used is a serum sample with a diagnosis of HIV. The method used in this examination is the Rapid Test method. The results of HIV testing on tuberculosis patients, sample data obtained from HIV tuberculosis co-infected respondents amounted to 30 HIV respondents who  took  tuberculosis  treatment >6-9 months, negative 6 patients (20%).
Kadar Ureum, Kreatinin, Serum Iron (SI) dan Total Iron Binding Capacity (TIBC) pada Pasien Chronic Kidney Disease (CKD) sebelum dan setelah Hemodialisis
Authors: Ariami Pancawati , Zaetun Siti , Gunaifi Aan , Diarti Maruni Wiwin
Published: October 2023

Tujuan  penelitian ini adalah untuk mengetahui kadar ureum, kreatinin, SI (serum iron) dan TIBC dalam darah sebelum dan sesudah hemodialisis. Jenis penelitian ini obervasional deskriptif.  Populasi dalam penelitian ini adalah keseluruhan pasien CKD RSUD Kota Mataram yang melakukan Hemodialisis. Sampel dalam penelitian ini menggunakan serum  pasien CKD yang melakukan Hemodialisis. Besar sampel 46 responden, Data  yang dikumpulkan kadar ureum, kreatinin, SI (serum iron) dan TIBC pada pasien CKD di RSUD Kota Mataram dianalis menggunakan uji Wilcoxon signed Rank Test pada tingkat kepercayaan 95% p α = 0,05. Hasil penelitian menunjukkan rerata kadar ureum, kreatinin, SI (serum iron) dan TIBC pada pasien CKD sebelum melakukan  hemodialisis berturut-turut sebesar 133,3 mg/dL ; 8,86 mg/dL ; 65,2 µg/dL ; dan 259,7 µg/dL. Rerata kadar ureum, kreatinin, SI (serum iron) dan TIBC pada pasien CKD setelah melakukan  hemodialisis berturut-turut sebesar 66,6 mg/dL ; 4,51 mg/dL ; 40,4 µg/dL ; dan 203,8 µg/dL. Kesimpulan hemodialisis berpengaruh terhadap kadar ureum, kreatinin, SI (serum iron) dan TIBC pada pasien CKD.
Perbedaan Hasil Pemeriksaan Widal Metode Slide menggunakan Sampel Serum dan Plasma EDTA pada Mahasiswa Teknologi Laboratorium Medik
Authors: Badriyah Nurul , Mulyanto Arif , Wardani Dita Pratiwi Kusuma , Sulistyowati Retno
Published: October 2023

Demam tifoid merupakan penyakit infeksi akut usus halus yang disebabkan oleh bakteri S. typhi dan S. paratyphi. Penyakit demam tifoid termasuk penyakit menular. Penularan disebabkan karena makanan atau minuman yang disajikan tidak bersih dan tingkat higenis individu sanitasi lingkungan. Pemeriksaan widal merupakan suatu pemeriksaan serologis untuk mendeteksi antibodi terhadap bakteri S. typhi yang berdasarkan reaksi aglutinasi antara antigen dengan antibodi yang disebut aglutinin, dengan mengukur aglutinasi titer antibodi terhadap antigen O dan H dalam sampel. Penelitian ini bertujuan untuk mengetahui ada tidaknya perbedaan nilai titer pada pemeriksaan widal yaitu metode slide sampel serum dan plasma EDTA dengan rancangan cros sectional sampel yang digunakan sebanyak 26. Pada Mahasiswa Teknologi Laboratorium Medik. Data yang dihasilkan dianalisis dengan uji univariat dan uji pearson chi square. Hasil penelitian ini didapatkan hasil pada serum terbanyak yaitu pada titer 1/320 (61,5%) sedangkan pada plasma EDTA terbanyak yaitu pada titer 1/80 (46,2%) yang menunjukan nilai p velue 0,0247 (p >0,05), maka berdasarkan hasil tersebut dapat disimpulkan bahwa tidak terdapat perbedaan antara pemeriksaan widal menggunakan sampel serum dan plasma EDTA antigen O dan H.
Islamic Boarding Schools' Food Handlers' Awareness Of Food Safety Issues And Their Actions In Relation To e. Coli Contamination Of Food
Authors: Sari Fitri Komala , Mahmudah Nur Aini , Luthfiya Lulu’ , Fathimah Fathimah , Ulfah Marya
Published: October 2023

Background: E. coli can grow due to foodborne illnesses, and according to Islamic law, the food consumed is not tayyib. Food handlers, including those in Islamic boarding schools, must know about food safety to prevent foodborne illnesses.Research Methods: At the Boarding School in East Java, a food production facility was used for the research. This study has a cross-sectional design and is quantitative. The sample used a total sampling method with a total of 38 samples. The gathered information was evaluated using the Spearman test. E. coli testing at the Islamic boarding school using the MPN technique on six food samples and water sources. Research Result: 25 food handlers are between 18 and 35, while 13 others are between 36 and 55. Higher-educated food handlers are on par with less-educated ones. Most people who handled food did so with a solid awareness of the characteristics of food safety behavior and knowledge. It is also believed that food workers' safety conduct is good because of their generally positive or good demeanor. Two food samples, S1 with an MPN value of 6.1/g and S2 with an MPN value of 7.2/g contained E. coli. The link had a value of 0.67 and a Spearman's correlation value of 0.070, indicating a positive relationship with weak correlation strength. The findings showed that awareness of food safety was not related to the prevalence of E. coli, with p>0.05 and 0.123. Conclusion: There was a positive correlation of 0,070 and a value of 0,067, indicating no link between food safety knowledge and behavior. The existence of E. coli did not correlate with knowledge of food safety, with a value of 0,13 and a negative correlation of -0,255.
The Relationship Between Fast Food Consumption, Pocket Money, And Quality Of Sleep With Over Nutrition In Adolescents
Authors: Kasmarini Fachira , Andriani Eka , Sabrina Sabrina
Published: October 2023

Background: Adolescents with obese nutritional status are at risk of experiencing degenerative diseases, which can reduce the quality of life of adolescents. The healthy rate of overweight and obesity is closely related to food intake and lifestyle. Consuming fast food has become a lifestyle for teenagers. This is also influenced by the amount of pocket money, making it easy for teenagers to get fast food. Another lifestyle factor that is related to obesity in adolescents is the quality of sleep. This study aims to determine the relationship between fast food consumption, pocket money, and sleep quality with the incidence of overweight in adolescents at SMA Negeri 1 Telukjambe Timur Karawang. Research Methods: This research was conducted at SMAN 1 Telukjambe Karawang. The respondents were grade 10 and 11 students aged 16-18 years. The sampling technique used purposive sampling with a total sample of 103 respondents. The method used is quantitative research with survey techniques utilizing a cross-sectional approach. Data analysis was performed with the chi-square test. The instruments used in this study were the Food Frequency Questionnaire (FFQ), the Pittsburgh Sleep Quality Index (PSQI) questionnaire, and the pocket money questionnaire. Research Result: Analysis of statistical test data using spearman rank. The results of the study showed that the majority of respondents aged 16 years were 74 people (71.8%), non-overnutrition were 76 people (73.8%), rarely consumed fast food as many as 59 people (57.3%), sleep quality 76 people (73.8%) have insufficient income, and 74 people (71.8%) have low pocket money. Conclusion: The conclusion in this study is that there is a relationship between the frequency of fast food consumption and the quality of sleep with the incidence of overweight, and there is no relationship between pocket money and the incidence of overweight and the fast food consumption habits of adolescents.
Correlation Between Stress Levels and Eating Behavior in College Students: A study at The Faculty of Health Sciences
Authors: Muhaimin Ilma Fauzia , Puspitasari Dyah Intan , Widiyaningsih Endang Nur , Hidayati Listyani
Published: October 2023

Background: The demanding schedules of students within the Faculty of Health Sciences and their substantial course loads frequently lead to elevated stress levels among students. Stress can manifest positive and negative impacts on an individual's eating behavior. This study aimed to establish a correlation between stress levels and eating behavior in students enrolled at the Faculty of Health Sciences, Universitas Muhammadiyah Surakarta.Research Methods: A cross-sectional research design was employed, involving 88 students from the 2019 Faculty of Health Sciences, Universitas Muhammadiyah Surakarta class as the respondents. Stress levels were assessed using the Perceived Stress Scale (PSS-10) questionnaire while eating behavior data were gathered through the Adult Eating Behavior Questionnaire (AEBQ). The Pearson product-moment correlation test examined the relationship between stress levels and eating behavior. Research Result: Among students of the Faculty of Health Sciences, Universitas Muhammadiyah Surakarta, in the 2019 class, 79.5% exhibited moderate stress levels. Regarding eating behavior, 54.5% of these students approached food, while 45.5% tended to avoid food. Notably, 54.5% of students from the Faculty of Health Sciences displayed mild levels of stress alongside an inclination toward approaching food in their behavior. The Pearson product-moment correlation test revealed a statistically significant relationship between stress levels and eating behavior, with a significance value of <0.05. Conclusion: This study establishes a significant correlation between stress levels and eating behavior among students at the Faculty of Health Sciences, Universitas Muhammadiyah Surakarta. Students must develop effective stress management strategies that are closely linked to regulating their eating behavior.
Study of Organoleptic Properties and Nutritional Content of Banana Brownies AS Healthy Snacks for School Children
Authors: Chandradewi AASP , Maulida Novia , Darawati Made , Suranadi Luh
Published: October 2023

Background: Snacks can help meet the nutritional needs of children who do not bring food to school. However, many snacks circulating in the community still need to be guaranteed for their safety or nutritional content. Efforts are required to meet nutritional needs by developing a product in the form of brownies as a healthy snack for school children using local food in the form of Ambon bananas as a substitute in making brownies. This research aims to determine the organoleptic properties and nutritional content of banana brownies as a healthy snack for school children.Research Methods: This study used an experimental method in the laboratory with a completely randomized design (CRD). Ambon banana puree substitution was carried out with three levels of treatment (25%, 50%, and 75% of the total flour), with three repetitions. Data on organoleptic properties were collected by organoleptic test using the hedonic method and statistically analyzed using Analysis Of Variance (One Way Annova) at the 95% confidence level (α = 0.05). Research Result: The results of the study of the organoleptic test of banana brownie products with 25% Ambon banana puree substitution of total wheat flour (20 grams) obtained a significant texture (≤ 0.05), while color, aroma, and taste were not substantial (> 0.05). Conclusion: The study of the organoleptic properties of banana brownies found that panelists preferred the treatment level, namely t1 (substitution of Ambon banana puree 25% of total flour). The nutritional value in 1 serving of 100 grams of banana brownies is 402.9 kcal of energy and 6.8 grams of protein.
EFEKTIVITAS PENYULUHAN KB IUD DENGAN MEDIA VIDEO ANIMASI TERHADAP TINGKAT PENGETAHUAN DAN SIKAP PASANGAN USIA SUBUR (PUS) DI DESA PUCUNG KABUPATEN PEKALONGAN
Authors: Shofa Fitri nur , Susiloningtyas Is , Susilowati Endang
Published: October 2023

ABSTRAK
 
Permasalahan: IUD merupakan salah satu metode kontrasepsi jangka panjang yang memiliki keefektifitasan yang sangat tinggi yaitu 0,6-0,8 kehamilan per 100 perempuan dalam 1 tahun pertama dengan 1 kegagalan dalam 125 sampai 170 kehamilan. Tujuan Penelitian: Mengetahui efektivitas penyuluhan KB IUD dengan media video animasi terhadap peningkatan pengetahuan dan sikap Pasangan Usia Subur (PUS) di Desa Pucung Kabupaten Pekalongan. Metode Penelitian: Rancangan penelitian ini adalah Pre eksperimen dengan one group pretest posttest. Jumlah sampel yang digunakan adalah 86 responden di Desa Pucung Kabupaten Pekalongan dengan tekhnik Purposive  Sampling. Analisis data yang digunakan adalah analisis Univariat dan Bivariat menggunakan Uji Wilcoxon. Hasil: Penyuluhan KB IUD dengan media video animasi efektif meningkatkan pengetahuan dan sikap pada ibu PUS di Desa Pucung Kabupaten Pekalongan. Nilai Asymp. Sig 0,000 p<0,05. Kesimpulan: Penyuluhan KB IUD dengan media video animasi efektif meningkatkan pengetahuan dan sikap pada ibu PUS di Desa Pucung Kabupaten Pekalongan. Saran: Diharapkan agar masyarakat Desa Pucung Kabupaten Pekalongan tetap melanjutkan kegiatan pemberian informasi baik melalui penyuluhan perorangan ataupun kelompok
 
Kata Kunci: Penyuluhan Media Video Animasi, KB IUD, PUS
STATUS GIZI ANAK SEKOLAH DI MI DARUSSALAM KOTA BENGKULU
Authors: Syafitri Irfina , Pratiwi Bintang Agustina
Published: October 2023

Problem: Children are one of Indonesia's future human resource assets that should receive more attention, especially those who are experiencing a period of growth and development, so they need adequate food consumption with balanced nutrition because strong, healthy, and intelligent children are a determinant of the nation's sustainability. Nutritional status is a measure of success in fulfilling nutrition for children. Research Objectives: This study aims to determine the nutritional status of school children at MI Darussalam, Bengkulu City. Research Methods: This study used a descriptive survey with a cross-sectional design. The population of this study was 131 students, with a total sample of 57 respondents. Then, the collection of data on nutritional status was carried out by weighing the weight using a stamping scale and measuring the height using a microtoise. Results: Assessment of children's nutritional status was carried out by calculating BMI (weight/height), and the results obtained were 43 respondents (75.4%) with good nutritional status, 5 (five) respondents (8.7%) with poor nutritional status, 7 (seven) respondents (12.2%) ) with more nutritional status and 2 (two) respondents (3.5%) with obesity. Conclusion: Malnutrition, overnutrition, and obesity are still found in children at MI Darussalam, Bengkulu City.
PkM Sosialisasi Manfaat Vaksin Covid-19 dan Pentingnya Bangkit Melawan Pandemi bagi Seluruh Masyarakat di Desa Sanrobone, Kecamatan Sanrobone, Kabupaten Takalar Tahun 2020
Authors: Idrus Hasta Handayani , Rasfayanah Rasfayanah
Published: October 2023

Pemberian vaksin merupakan salah satu upaya yang dinilai paling efektif untuk mengatasi pandemi COVID-19 yang masih terus berlangsung. Tujuannya adalah untuk membuat sistem kekebalan tubuh mengenali dan mampu melawan saat terkena penyakit tersebut. Sebenarnya, sistem kekebalan tubuh terhadap suatu penyakit bisa terbentuk secara alami saat seseorang terinfeksi virus atau bakteri penyebabnya. Namun, infeksi virus Corona memiliki risiko kematian dan daya tular yang tinggi. Oleh karena itu, diperlukan cara lain untuk membentuk sistem kekebalan tubuh, yaitu vaksinasi. Seseorang yang mendapatkan vaksin COVID-19 juga dapat melindungi orang-orang di sekitarnya, terutama kelompok yang sangat berisiko, seperti lansia. Hal ini karena kemungkinan orang yang sudah divaksin untuk menularkan virus Corona sangatlah kecil. Kegiatan ini memberikan penyuluhan Sosialisasi Manfaat dari Vaksin Covid-19 dan Pentingnya bangkit melawan pandemi bagi seluruh masyarakat di Desa Sanrobone Kecamatan Sanrobone Kabupaten Takalar Sulawesi Selatan. Menambah pengetahuan dan pemahaman masyarakat mengenai manfaat dari Vaksin Covid-19, memberikan bahan ajar seperti banner, poster, leaflet bergambar yang mudah dipahami dan dapat dipergunakan setelah kegiatan ini. Berdasarkan dari data hasil kuesioner (pre dan posttest) pada peserta, didapatkan peningkatan pemahaman tentang pengetahuan mengenai manfaat vaksinasi Covid-19 dan tidak lagi percaya terhadap berita hoax yang beredar seputar vaksin Covid-19. Dari hasil evaluasi tersebut, disimpulkan bahwa kegiatan ini terlaksana dengan baik; masyarakat jadi lebih mengetahui manfaat vaksinasi Covid-19, dan tidak lagi takut untuk mendapatkan vaksinasi sehingga membantu pemerintah dalam meratakan pemberian vaksin Covid-19.
FACILITATING SUSTAINABLE DEVELOPMENT OF PRESCHOOLS: A SYSTEM THINKING TRAINING PROJECT IN TAIWAN
Authors: Cheng Ching-Ching , Huang Kuo-Hung , Lin Yi-Kai
Published: October 2023

This study aims to assist preschools in achieving sustainable development by providing system thinking training for teachers and administrators. By promoting system thinking and PDCA, training helps preschool staff and teachers construct their knowledge and culture for organizational growth and effective operation. The research procedure encompasses stages of preparation, knowledge diffusion, knowledge adaptation, and establishing support networks. A total of 744 training participants engage in case studies, discussions, and self-evaluation activities to enhance their understanding and application of the PDCA framework. Quantitative and qualitative methods are used to collect the research participants' perceptions and intentions on this training. Research data is collected using 5-point Likert questionnaires, supplemented with open-ended questions to gather participants' perceptions and suggestions. In addition, qualitative data is obtained through onsite observation, focus groups, and individual interviews. The research results indicate that participants in the training program positively perceive the training activities. Also, those with administrative roles and from non-profit preschools exhibit higher interest and motivation for training, reflecting the need for sustainability knowledge in changing environments.
Keywords: sustainable development, system thinking, PDCA, preschool teacher, early childhood education
DIGITAL CITIZENSHIP IN GEORGIAN’S TEACHERS, STUDENTS AND PARENTS
Authors: Lobzhanidze Sofiko , Urchukhishvili Giorgi , Sikharulidze Marika
Published: October 2023

The Council of Europe’s (CoE) model on Digital Citizenship Education (DCE) has at its basis the ‘Competencies of Democratic Culture’ model, which considers being an active and responsible citizen and implies the development of a set of lifelong competencies both online and offline at various levels, as well. Taking the ‘Competencies of Democratic Culture’ the CoE experts elaborated on the DCE domains, which are the appropriate way to develop democratic culture competences in the digital environment. Georgia, as a member country, signed the agreement on DCE to be applied at the K-12 curriculum level and joined the DCE project of the CoE in July 2020. Thus, as an educational concept, DCE is relatively new to the education system of Georgia. The aim of the study was to describe the current situation concerning DCE in Georgia, namely on awareness of the concept and its foundations, as well as identifying self-reported DCE competences by teachers, students and parents, in the light of the Ribble’s and the CoE’s models. Data was collected in five schools in 2020. The issue was studied using the quantitative method, an online survey, 1954 respondents were involved in the research. It was demonstrated that most of the respondents had a lack of awareness about information-communication technologies. It can be concluded that communication among school teachers, students and parents about the issues of digital security has not started yet. The correlation between the geographic location of a school and teachers’ digital competences is not confirmed.
Keywords: digital citizenship education, digital domains, digital competences, digital school culture, exploratory sequential design
THE INFLUENCE OF SELECTED FACTORS ON THE LOWER SECONDARY SCHOOL TEACHERS' PERCEPTION OF MEDIA EDUCATION
Authors: Sochorova Dagmar , Kubiatko Milan
Published: October 2023

Media education is an educational subject whose parent fields are not firmly defined. It is located at the intersection of subjects like pedagogy, media studies, film science, aesthetics, sociology, psychology and other humanities and social disciplines. The aim of the research was to determine the influence of various factors on the perception of media education among teachers. 600 teachers participated in the research, and the research tool was a self-designed questionnaire. It was divided into several parts, with the media part containing 12 items focused on the perception of education. The multiple regression model was used as the statistical method for the identification of significant factors. Also, Pearson’s correlation coefficient and a student t-test were used for the identification of a significant relationship and whether the use of different methods and forms had a significant effect on media education perception. The length of teaching experience, the benefits of media education in the areas of knowledge, abilities and skills, as well as the last variable – receptive circles, were shown to be significant factors. Higher implementation of media education into the school subjects would be beneficial for every participant of the teaching process.
Keywords: teachers’ perception, media education, multiple regression model, quantitative approach
La responsabilidad penal en la intervención médica en cirugías estéticas
Authors: Luna Idrovo Sebastián Antonio , Zamora Vázquez Ana Fabiola
Published: October 2023

Introducción: La intervención médica, especialmente en el ámbito de las cirugías plásticas, es una actividad delicada en la que los profesionales de la salud deben actuar con suma pericia y conocimiento. Sin embargo, surgen preocupaciones en cuanto a las posibles consecuencias legales para aquellos médicos que, por negligencia o impericia, y falta de deber objetivo de cuidado dañan a sus pacientes. Objetivos: El objetivo fundamental de la investigación es determinar la responsabilidad penal que recae sobre el médico en las intervenciones quirúrgicas, en especial en cirugías plásticas, con la finalidad de asegurar un buen derecho a la salud. Se buscó profundizar en la manera en que se juzga y se sanciona la impericia, el desconocimiento y la negligencia y la falta de deber objetivo de cuidado en este campo. Metodología: Para lograr una comprensión holística del tema, se adoptó un enfoque cualitativo, fundamentado teóricamente en datos científicos y jurisprudenciales extraídos de revistas indexadas. Además, se realizó un análisis comparativo del derecho en España, Colombia y Chile, con el propósito de discernir las legislaciones pertinentes a la responsabilidad penal de los profesionales de la salud en estos países. Conclusión: Tras una revisión exhaustiva, se concluye que no actuar con la debida sensatez en actividades médicas que ponen en riesgo la vida humana puede tener consecuencias legales. Sin embargo, no se pudo determinar con precisión la responsabilidad penal en el ámbito específico de las cirugías plásticas en Ecuador, a pesar de ser estas las intervenciones con un mayor número de incidencias y fatales desenlaces en el país. Área de estudio general: Derecho. Área de estudio específica: Derecho Procesal.
Analysis of Solar Power Plant Development Potential in Adipala - Cilacap
Authors: Saputri Fahmy Rinanda , Linelson Ricardo , Lee Vincentius Rayza
Published: October 2023

PT Pertamina (Persero) as the vanguard of the archipelago's energy has committed to finding and developing new and renewable energy sources to support national energy independence and sovereignty. One of the concrete steps taken by PT Pertamina through the Cilacap Processing Unit IV is to build a Solar Power Plant. One of the strategic solar power plant construction sites in an empty land area close to the 500 kV Adipala Sutet Power Network is located in Cilacap regency with an average global horizontal irradiation (GHI) value of 1908 kWh/m2. With this value, the installation of solar rooftops is the right solution to support electricity production using renewable energy. The electricity load consumption from the city in one year is 1785.6 KWh and is currently entirely supplied by PLN. In this study, a Solar Power Plant design was carried out on vacant land around housing that can be produced in one year. The design and calculations were carried out using the help of PVSyst and RETScreen software. From the simulation results, the results obtained are a Solar Power Plant that has been designed to produce 463 kWh per year which can meet 25.9% of electricity needs at the design site with a Solar Power Plant performance ratio of 85.74% where Solar Power Plant can produce electrical energy of 1531 KWh per year.
Sistem Monitoring Tempat Penampungan Sementara (TPS) Berbasis Internet of Things (IoT)
Authors: Pahruzi Ihqrom , Munazilin Akhlis , Baijuri Achmad
Published: October 2023

Berawal dari permasalahan sampah yang berserakan sekitar area tempat penampungan sementara (TPS) disebabkan kurangnya  fasilitas armada. Permasalahan tersebut sekarang dapat diatasi dengan sebuah penelitian sistem monitoring tempat penampungan sementara (TPS) berbasis Internet of Things (IoT). Teknik pengembangan sistem yang digunakan adalah metode prototipe, yang dapat mengatasi permasalahan antara user dan analis. Sistem monitoring tempat penampungan sementara (TPS) ini menggunakan teknologi ESP32 dan sensor ultrasonik HC-SR04 untuk mengukur volume sampah. Sementara itu, sebagai hasilnya, web server thingspeak digunakan sebagai kerangka kerja pengamatan jarak jauh untuk benar-benar melihat sampah. Hal ini dapat membantu petugas pengangkut sampah untuk mengoptimalkan armada yang ada. Hasil yang diperoleh dari penelitian ini adalah pendektesi sensor terhadap level sampah 1 - 4,9 inci  level penuh, 5 -9,9 inci level sampah setengah, level sampah 10 – 15 inci level kosong. Semua data ditemukan sesuai dengan hasil pengirimannya ke web server thingspeak.
Perbandingan Algoritma Run Length Encoding (RLE) dan Algoritma Variable Length Binary Encoding (VLBE) dalam Mengkompresi File Video Untuk Menghemat Penyimpanan
Authors: Adillah Nur , Nasution Yusuf Ramadhan , Armansyah
Published: October 2023

Kompresi dilakukan guna membuat ukuran file tersebut lebih kecil. Algoritma merupakan urutan langkah-langkah yang bertujuan untuk menyelesaikan suatu persoalan. Pada penelitian ini menggunakan algoritma Run Length Encoding (RLE) dan algoritma Variable Length Binary Encoding (VLBE). Format file video yang dalam penelitian ini adalah .avi dan .mp4 dan menggunakan Microsoft Visual Studio dengan bahasa pemrograman C# berbasis desktop. Hasil dari penelitian ini adalah file yang video yang telah dikompresi akan memperlihatkan performanya dan parameter perbandingan berdasarkan Ratio of Compression (RC), Compression Ratio (CR), dan Redudancy (RD) diantara algoritma Run Length Encoding (RLE) dan algoritma Variable Length Binary Encoding (VLBE). Dengan permasalahan tersebut penulis ingin membuat suatu penelitian skripsi yang berjudul ‘Perbandingan Algoritma Run Length Encoding (RLE) Dan Algoritma Variable Length Binary Encoding (VLBE) Dalam Mengkompresi File Video Untuk Menghemat Penyimpanan’.
Hydrogen Valleys: Assessing the EU Legal and Financial Frameworks that Enable the Hydrogen Economy
Authors: Bonafé Ernesto , Conte Marco , Bouchaar Katharina
Published: October 2023

To achieve the target of 10 million tonnes of renewable hydrogen production in the European Union (EU) by 2030, the REPowerEU Plan commits the EU to double the number of hydrogen ‘valleys’, which will contribute to accelerating the production of renewable hydrogen to replace natural gas, coal and oil in hard-to-decarbonise economic sectors. This article reviews ongoing efforts to lay down a regulatory framework to move from natural gas to renewable hydrogen and, not least, to define renewable hydrogen. As a strategic net-zero industry, renewable hydrogen is to grow and flourish in hydrogen valleys, meaning a place where energy production and multiple-uses will meet and expand. This requires substantial EU financial support, at least until renewable hydrogen becomes a mature technology that can compete in the market with today's cheaper (and polluting) fossil-based hydrogen. While there are open questions about the pace and viability of hydrogen-related technologies and infrastructure, for instance concerning long-distance transportation, hydrogen valleys appear as a no-regret option encompassing renewable energy production, repurposed gas infrastructure, electricity grid and batteries. If successfully implemented, the option would enhance renewable hydrogen production and the decarbonisation of the industry and transport.
Sustainable Energy Governance and the Notion of State Failure
Authors: Bekker Pieter H F , Watt CVO James W
Published: October 2023

Intractable sovereignty disputes and outside interventions driven by geo-political calculations challenge the rules-based global order and undermine sustainable development and governance, including of energy resources. States facing chronic conflict and instability, and falling short of fundamental norms of international law as enshrined in the United Nations Charter, are labelled as ‘failed States’ without recognising the deterioration of the global order. This article submits that the one-dimensional notion of a ‘failed State’ is problematic and unhelpful. It advocates a more nuanced, sustainability-based approach of State failure in addressing problems associated with governance of energy resources. It does so with reference to two examples from State practice: Russia’s position in the Arctic region in light of the receding ice cap and estimated hydrocarbon reserves in the Arctic Ocean, and the recent US-brokered maritime boundary agreement between Lebanon and Israel enabling Lebanon to gain access to disputed offshore resources without Russian involvement.
Integrity, Vulnerability, and Temporality
Authors: Traina Cristina
Published: October 2023

This paper asks how to account for vulnerable integrity in the temporal dynamism of human lives without relying on a subtractive vision of integral human nature, borrowing from presumed past or future rationality and maturity, or depending on an external attribution of dignity. Illustrating the challenges with vignettes from the author’s life, it argues inductively that human integrity includes morally inviolable vulnerability to others with whom we are in interdependent relationship and without whom we cannot develop or maintain our selves. Others reside at the core of our integrity, for better and for worse, and we reside at theirs. Augustine’s accounts of memory, time, and the narrative self; Whiteheadian process thought’s understanding of continuity through change; and feminist theories of narrative all provide theological and philosophical justifications for this vision of integrity. John Wall’s and Johan Brännmark’s non-foundational approaches to integrity and human rights lead us to the same conclusion without entailing theological anthropological claims, ensuring its relevance in a pluralist culture.
Self-determined Sex Work as Care Work Between Experiences of Integrity and Vulnerability
Authors: Jäger Sarah
Published: October 2023

Sex work or prostitution marks a controversial topic for Protestant sexual ethics. It is also a multifaceted phenomenon because it can occur in very different forms: the spectrum ranges from poverty, emergency and procurement prostitution to the self-determined and insured sex worker with all imaginable shades in between. In the current economic system, goods and services are exchanged, traded, sold, acquired and paid for, so sex work can also be understood as work.  For the purposes of this article, we will therefore start from an understanding of sex work as care work. Care work can be understood as the satisfaction of needs and interests of third parties and the self. If sex work is discussed as care work, this has a variety of consequences. These include the fact that questions of vulnerability and integrity come to the fore. Integrity can be comprehended as self-realisation or autonomy and thus as potentially vulnerable, taking up Axel Honneth’s early reflections on the issue of recognition. Integrity in Axel Honneth’s sense can - according to a first approximation - play a role for sex work on three levels: physical or corporeal level, structural level and lifestyle or way of life level. Finally, the essay discusses the concept of negotiated or consensual morality as a contribution of Protestant ethics.
Chronic disturbance induces attenuation of the acute glucocorticoid response in an urban adapter, the dark-eyed junco
Authors: Hanauer Rachel E. , Abolins-Abols Mikus , Brenner Abigail M. , Gall Baili J. , Ketterson Ellen D.
Published: October 2023

Urban birds’ stress response frequently differs in magnitude from non-urban conspecifics. This urban phenotype may reflect response to selection, sorting during colonization of urban environments, developmental plasticity, or phenotypic flexibility in response to urban environments. We investigated whether exposure to one characteristic of an urban environment, chronic disturbance, could induce an attenuated acute glucocorticoid response over a short time in adult non-urban dark-eyed juncos (Junco hyemalis), which, if true, would support the phenotypic flexibility hypothesis. We tested this during the period of spring gonadal recrudescence. We simulated a high-disturbance urban-like environment by exposing non-urban experimental birds to chronic disturbance (30-min psychological stressors 4x/day for 3 weeks); controls were minimally disturbed. We found that chronically disturbed birds had a lower acute corticosterone response after 3 weeks of treatment. Baseline corticosterone was not affected. Chronically disturbed birds had less body fat and lower body condition than controls at the end of the experiment, although on average all birds gained weight over the course of the experiment. Feathers grown during the experiment did not show an effect of the disturbance treatment on feather corticosterone or fault bars, although captive-grown feathers had lower corticosterone and more fault bars than wild-grown feathers. We conclude that adult male juncos have the capacity to attenuate their acute corticosterone response in an environment with high frequency of disturbance, potentially facilitating colonization of urban habitats. Future research may show whether successful urban colonists differ from unsuccessful species in this regard.
Hyper-inflammatory profile and immunoparalysis in patients with severe Legionnaires’ disease
Authors: Allam Camille , Mouton William , Testaert Hugo , Ginevra Christophe , Fessy Noémie , Ibranosyan Marine , Descours Ghislaine , Beraud Laetitia , Guillemot Johann , Chapalain Annelise , Albert-Vega Chloé , Richard Jean-Christophe , Argaud Laurent , Friggeri Arnaud , Labeye Vanessa , Jamilloux Yvan , Freymond Nathalie , Venet Fabienne , Lina Gérard , Doublet Patricia , Ader Florence , Trouillet-Assant Sophie , Jarraud Sophie
Published: October 2023

Introduction

Severe Legionnaires’ disease (LD) can lead to multi-organ failure or death in 10%–30% of patients. Although hyper-inflammation and immunoparalysis are well described in sepsis and are associated with high disease severity, little is known about the immune response in LD. This study aimed to evaluate the immune status of patients with LD and its association with disease severity.

Methods

A total of 92 hospitalized LD patients were included; 19 plasmatic cytokines and pulmonary Legionella DNA load were measured in 84 patients on the day of inclusion (day 0, D0). Immune functional assays (IFAs) were performed from whole blood samples collected at D2 and stimulated with concanavalin A [conA, n = 19 patients and n = 21 healthy volunteers (HV)] or lipopolysaccharide (LPS, n = 14 patients and n = 9 HV). A total of 19 cytokines (conA stimulation) and TNF-α (LPS stimulation) were quantified from the supernatants. The Sequential Organ Failure Assessment (SOFA) severity score was recorded at D0 and the mechanical ventilation (MV) status was recorded at D0 and D8.

Results

Among the 84 patients, a higher secretion of plasmatic MCP-1, MIP1-β, IL-6, IL-8, IFN-γ, TNF-α, and IL-17 was observed in the patients with D0 and D8 MV. Multiparametric analysis showed that these seven cytokines were positively associated with the SOFA score. Upon conA stimulation, LD patients had a lower secretion capacity for 16 of the 19 quantified cytokines and a higher release of IL-18 and MCP-1 compared to HV. IL-18 secretion was higher in D0 and D8 MV patients. TNF-α secretion, measured after ex vivo LPS stimulation, was significantly reduced in LD patients and was associated with D8 MV status.

Discussion

The present findings describe a hyper-inflammatory phase at the initial phase of Legionella pneumonia that is more pronounced in patients with severe LD. These patients also present an immunoparalysis for a large number of cytokines, except IL-18 whose secretion is increased. An assessment of the immune response may be relevant to identify patients eligible for future innovative host-directed therapies.
Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2
Authors: Hoffmann Helen , Ebensperger Marina , Schönsiegel Annika , Hamza Hazem , Koch-Heier Julia , Schreiber André , Ludwig Stephan , Schindler Michael , Planz Oliver
Published: October 2023

The recent COVID-19 pandemic again highlighted the urgent need for broad-spectrum antivirals, both for therapeutic use in acute viral infection and for pandemic preparedness in general. The targeting of host cell factors hijacked by viruses during their replication cycle presents one possible strategy for development of broad-spectrum antivirals. By inhibiting the Raf/MEK/ERK signaling pathway, a central kinase cascade of eukaryotic cells, which is being exploited by numerous viruses of different virus phyla, the small-molecule MEK inhibitor zapnometinib has the potential to address this need. We here performed a side-by-side comparison of the antiviral efficacy of zapnometinib against IAV and SARS-CoV-2 to determine the concentration leading to 50% of its effect on the virus (EC50) and the concentration leading to 50% reduction of ERK phosphorylation (IC50) in a comparable manner, using the same experimental conditions. Our results show that the EC50 value and IC50 value of zapnometinib are indeed lower for IAV compared to SARS-CoV-2 using one representative strain for each. The results suggest that IAV’s replication has a stronger dependency on an active Raf/MEK/ERK pathway and, thus, that IAV is more susceptible to treatment with zapnometinib than SARS-CoV-2. With zapnometinib’s favorable outcome in a recent phase II clinical trial in hospitalized COVID-19 patients, the present results are even more promising for an upcoming phase II clinical trial in severe influenza virus infection.
Ecological space resilience assessment of Baiyangdian Basin from the perspective of evolutionary resilience
Authors: Liang Xinyu , Gao Xing , Zhao Meiran , Guo Zhongyuan , Shen Weining
Published: October 2023

The structure and function of ecological spaces play a crucial role in resisting risk interference and providing ecological services. Conducting resilience assessments of ecological spaces is of great significance for maintaining ecological security. Taking the Baiyangdian Basin as the research object, based on the evaluation results of ecosystem service function importance and ecological environmental sensitivity, the ecological space importance level of the Baiyangdian Basin is divided. Based on the three basic characteristics of “resistance, adaptability, recoverability”, the resilience of ecological space model was constructed by selecting ecosystem service value, landscape structure stability, ecological resilience model and coefficient. The research results show that: (1) The overall importance index of ecological space in the Baiyangdian Basin is relatively low. The non-critical area accounted for 43.00% of the total area, the general area accounted for 30.78%, and the core area accounted for 26.22%, which mainly distributed in the northern part of the study area and at the confluence of rivers. (2) The proportion of areas with extremely important ecosystem service functions in Baiyangdian Basin is 31.73%, concentrated in the central and southwestern parts of the basin. The highly sensitive ecological environment areas accounted for 21.96%, mainly distributed in high-altitude areas in the northern part of the basin and river convergence areas. (3) On the whole, the overall resilience level of the study area is not high and there is a significant difference in resilience between the north and south, with 68.60% of the regions in the low level of resilience. The area with high resilience level accounted for only 1.51%, and the highest resilience level was found at river confluence. The research results provide a theoretical basis for maintaining and improving the ecological environment of the basin, and provide a basis for implementing precise policies to optimize the ecological space of the basin.
Molecular profiling of clinical remission in psoriatic arthritis reveals dysregulation of FOS and CCDC50 genes: a gene expression study
Authors: Angioni Maria Maddalena , Floris Alberto , Cangemi Ignazio , Congia Mattia , Chessa Elisabetta , Naitza Micaela Rita , Piga Matteo , Cauli Alberto
Published: October 2023

Background

In psoriatic arthritis (PsA), the primary goal of treatment is clinical remission. This study aimed to characterize the molecular profile underlying the induced clinical remission in patients with PsA, comparing the remission state and the healthy condition.

Methods

Whole blood transcriptomic analysis was performed on groups of 14 PsA patients in TNFi-induced clinical remission (DAPSA ≤ 4), 14 PsA patients with active disease (DAPSA > 14), and 14 healthy controls (HCs). Then, all differentially expressed genes (DEGs) derived from remission vs. HC comparison were analyzed for functional and biological characteristics by bioinformatics software. The gene expression of 12 genes was then validated by RT-qPCR in an extended cohort of 39 patients in clinical remission, 40 with active disease, and 40 HCs.

Results

The transcriptomic analysis of PsA remission vs. HCs highlighted the presence of 125 DEGs, and out of these genes, 24 were coding genes and showed a great involvement in immune system processes and a functional network with significant interactions. The RT-qPCR validation confirming the down- and upregulation of FOS (FC −2.0; p 0.005) and CCDC50 (FC +1.5; p 0.005) genes, respectively, in line with their role in orchestrating inflammation and bone metabolism processes, may be related to PsA pathophysiology.

Conclusion

The transcriptomic profile of clinical remission in PsA is similar to a healthy condition, but not identical, differing for the expression of FOS and CCDC50 genes, which appears to play a key role in its achievement.
Hail netting: an economically competitive IPM alternative to insecticides for Midwest apple production
Authors: DiGiacomo Gigi , Nelson Sally G. A. , Jacobson John , Klodd Annie , Hutchison William D.
Published: October 2023

Apple orchards are highly managed agricultural ecosystems where growers typically rely on insecticides to minimize the risk of pest-related fruit losses. Apple growers practicing integrated pest management require cost-effective alternatives to conventional insecticides for control of major pests such as codling moth (Cydia pomonella L.) and apple maggot (Rhagoletis pomonella Walsh). Exclusion netting has been shown to effectively control multiple insect pest species, limit fruit damage and reduce the use of insecticides while also conferring consumer and environmental benefits. In this study, partial budgeting was applied to explore the financial efficacy of using a hail netting (DrapeNet®) system as a sustainable pest management strategy for Midwest U.S. apple (Malus x domestica). The cost of the hail netting was compared to a common Midwest insecticide spray regimen for apples using yield and quality data from a field study at two Minnesota apple orchards in 2021-2022. The PB analysis indicated that the netting system was an economically competitive alternative to conventional insecticide applications. The economic results were robust across a range of apple prices and yields suggesting that Minnesota apple growers can benefit economically from the application of hail netting for sustainable pest management.