bluuebunny/crossref_metadata_2025 huggingface dataset:
Interleukin-33 and soluble suppression of tumorigenicity 2 in scleroderma cardiac involvement
Authors: Iannazzo Francesco , Pellicano Chiara , Colalillo Amalia , Ramaccini Cesarina , Romaniello Antonella , Gigante Antonietta , Rosato Edoardo
Published: July 2022

Interleukin (IL)-33 is part of the IL-1 family of cytokines and soluble suppression of tumorigenicity 2 (sST2) is part of the family of IL-1 receptors. In systemic sclerosis (SSc), IL-33 and sST2 are involved in cardiac manifestations such as diastolic dysfunction (DD), autonomic dysfunction (AD) and right ventricular–pulmonary arterial coupling assessed by tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (sPAP). Serum levels of IL33 and sST2 were assessed in 50 SSc patients and 14 healthy controls (HC). Clinical assessment, echocardiography and heart rate variability (HRV) analysis were performed in SSc patients. Serum levels of IL-33 and sST2 were significantly higher in SSc patients than HC. A linear positive correlation between modified Rodnan skin score and IL33 was observed. Serum values of sST2 were higher in SSc patients with DD than in patients without DD [15403 pg/ml (12,208–19,941) vs 8556 pg/ml (6820–11,036), p < 0.001]. sST2 showed a negative correlation with standard deviation of normal-to-normal RR intervals (SDNN) (r = − 0.281, p < 0.05) and positive correlation with low frequency/high frequency (LF/HF) (r = 0,349, p < 0.01). Negative linear correlation exists between sST2 and TAPSE/sPAP (r = − 0.398, p < 0.01). Serum levels of IL-33 and sST2 are higher in SSc patients than HC. Serum levels of sST2 are a potential marker of DD, AD and right ventricular–pulmonary arterial coupling.
A Continuum-Tensegrity Computational Model for Chondrocyte Biomechanics in AFM Indentation and Micropipette Aspiration
Authors: Arduino Alessandro , Pettenuzzo Sofia , Berardo Alice , Salomoni Valentina A. , Majorana Carmelo , Carniel Emanuele Luigi
Published: July 2022

Mechanical stimuli are fundamental in the development of organs and tissues, their growth, regeneration or disease. They influence the biochemical signals produced by the cells, and, consequently, the development and spreading of a disease. Moreover, tumour cells are usually characterized by a decrease in the cell mechanical properties that may be directly linked to their metastatic potential. Thus, recently, the experimental and computational study of cell biomechanics is facing a growing interest. Various experimental approaches have been implemented to describe the passive response of cells; however, cell variability and complex experimental procedures may affect the obtained mechanical properties. For this reason, in-silico computational models have been developed through the years, to overcome such limitations, while proposing valuable tools to understand cell mechanical behaviour. This being the case, we propose a combined continuous-tensegrity finite element (FE) model to analyse the mechanical response of a cell and its subcomponents, observing how every part contributes to the overall mechanical behaviour. We modelled both Atomic Force Microscopy (AFM) indentation and micropipette aspiration techniques, as common mechanical tests for cells and elucidated also the role of cell cytoplasm and cytoskeleton in the global cell mechanical response.
The Potential of Semaglutide Once-Weekly in Patients Without Type 2 Diabetes with Weight Regain or Insufficient Weight Loss After Bariatric Surgery—a Retrospective Analysis
Authors: Lautenbach Anne , Wernecke Marie , Huber Tobias B. , Stoll Fabian , Wagner Jonas , Meyhöfer Sebastian M. , Meyhöfer Svenja , Aberle Jens
Published: July 2022

Purpose

About 20–25% of patients experience weight regain (WR) or insufficient weight loss (IWL) after bariatric metabolic surgery (BS). Therefore, we aimed to retrospectively assess the effectiveness of adjunct treatment with the GLP-1 receptor agonist semaglutide in non-diabetic patients with WR or IWL after BS.

Materials and Methods

Post-bariatric patients without type 2 diabetes (T2D) with WR or IWL (n = 44) were included in the analysis. The primary endpoint was weight loss 3 and 6 months after initiation of adjunct treatment. Secondary endpoints included change in BMI, HbA1c, lipid profile, hs-CRP, and liver enzymes.

Results

Patients started semaglutide 64.7 ± 47.6 months (mean ± SD) after BS. At initiation of semaglutide, WR after post-bariatric weight nadir was 12.3 ± 14.4% (mean ± SD). Total weight loss during semaglutide treatment was − 6.0 ± 4.3% (mean ± SD, p < 0.001) after 3 months (3.2 months, IQR 3.0–3.5, n = 38) and − 10.3 ± 5.5% (mean ± SD, p < 0.001) after 6 months (5.8 months, IQR 5.8–6.4, n = 20). At 3 months, categorical weight loss was > 5% in 61% of patients, > 10% in 16% of patients, and > 15% in 2% of patients. Triglycerides (OR = 0.99; p < 0.05), ALT (OR = 0.87; p = 0.05), and AST (OR = 0.89; p < 0.05) at baseline were negatively associated with weight loss of at least 5% at 3 months’ follow-up (p < 0.05).

Conclusion

Treatment options to manage post-bariatric excess weight (regain) are scarce. Our results imply a clear benefit of adjunct treatment with semaglutide in post-bariatric patients. However, these results need to be confirmed in a prospective randomized controlled trial to close the gap between lifestyle intervention and revision surgery in patients with IWL or WR after BS.

Graphical abstract
Cancer Stem Cells and the Tumor Microenvironment: Targeting the Critical Crosstalk through Nanocarrier Systems
Authors: Nayak Aadya , Warrier Neerada Meenakshi , Kumar Praveen
Published: July 2022

The physiological state of the tumor microenvironment (TME) plays a central role in cancer development due to multiple universal features that transcend heterogeneity and niche specifications, like promoting cancer progression and metastasis. As a result of their preponderant involvement in tumor growth and maintenance through several microsystemic alterations, including hypoxia, oxidative stress, and acidosis, TMEs make for ideal targets in both diagnostic and therapeutic ventures. Correspondingly, methodologies to target TMEs have been investigated this past decade as stratagems of significant potential in the genre of focused cancer treatment. Within targeted oncotherapy, nanomedical derivates—nanocarriers (NCs) especially—have emerged to present notable prospects in enhancing targeting specificity. Yet, one major issue in the application of NCs in microenvironmental directed therapy is that TMEs are too broad a spectrum of targeting possibilities for these carriers to be effectively employed. However, cancer stem cells (CSCs) might portend a solution to the above conundrum: aside from being quite heavily invested in tumorigenesis and therapeutic resistance, CSCs also show self-renewal and fluid clonogenic properties that often define specific TME niches. Further scrutiny of the relationship between CSCs and TMEs also points towards mechanisms that underly tumoral characteristics of metastasis, malignancy, and even resistance. This review summarizes recent advances in NC-enabled targeting of CSCs for more holistic strikes against TMEs and discusses both the current challenges that hinder the clinical application of these strategies as well as the avenues that can further CSC-targeting initiatives.

Graphical abstract

Central role of CSCs in regulation of cellular components within the TME
Encapsulated trajectory tracking control for autonomous vehicles
Authors: Homolla Tobias , Winner Hermann
Published: July 2022

The motion control of autonomous vehicles with a modular, service-oriented system architecture poses new challenges, as trajectory-planning and -execution are independent software functions. In this paper, requirements for an encapsulated trajectory tracking control are derived and it’s shown that key differences to conventional vehicles with an integrated system architecture exist, requiring additional attention during controller design. A novel, encapsulated control architecture is presented that incorporates multiple extensions and support functions, fulfilling the derived requirements. It allows the application within the modular architecture without loss of functionality or performance. The controller considers vehicle stability and enables the yaw motion as an independent degree of freedom. The concept is applied and validated within the vehicles of the UNICARagil research project, that feature the previously described system architecture to increase flexibility of application by dynamically interconnecting services based on the current use-case.
Hegel on Market Laws and External Teleology
Authors: Baumann Charlotte
Published: July 2022

By highlighting the logico-metaphysical undergirding of Hegel's discussion of the market, this article brings to light certain proto-Marxist or proto-socialist tendencies in Hegel as well as key disagreements with Adam Smith, which have been missed by recent studies like Herzog's Inventing the Market (2013). For Smith, market laws function like an impartial arbiter that rewards honest effort; his main worry is that individuals may fail to display virtues like honesty, probity and frugality, thereby hindering the smooth functioning of the market mechanism. For Hegel, by contrast, the market is a de-personalized player in its own right that imposes its arbitrary rule, a rule that does not reflect in any way the virtues and efforts of market participants. This assessment is easily overlooked, unless one realizes that Hegel believes the market to be functioning according to the structures that he discusses in the ‘Objectivity’ section in his Science of Logic. As a consequence of this assessment Hegel attributes a different role to the state than Smith does: Rather than aiding and shaping individuals, by means of institutions, education and health care, the state needs to address the structural functioning of market laws and, to some extent, inhibit its free-flowing functioning. Individuals need to re-appropriate their own social relations by organizing them along the lines of the logical organism or internal teleology. After outlining Hegel's interpretation and assessment of the market structures with the help of the Logic, I will discuss Hegel's demand for an organic state, that sublates and oversees the market, thereby safeguarding the important personal freedoms enjoyed by market participants.
Turbulent Rayleigh–Bénard convection with bubbles attached to the plate
Authors: Liu Hao-Ran , Chong Kai Leong , Yang Rui , Verzicco Roberto , Lohse Detlef
Published: July 2022

We numerically investigate turbulent Rayleigh–Bénard convection with gas bubbles attached to the hot plate, mimicking a core feature in electrolysis, catalysis or boiling. The existence of bubbles on the plate reduces the global heat transfer due to the much lower thermal conductivity of gases as compared with liquids and changes the structure of the boundary layers. The numerical simulations are performed in three dimensions at Prandtl number

$\mbox{Pr}=4.38$

(water) and Rayleigh number

$10^7\leqslant \mbox{Ra}\leqslant 10^8$

. For simplicity, we assume the bubbles to be equally sized and having pinned contact lines. We vary the total gas-covered area fraction

$0.18 \leqslant S_0 \leqslant 0.62$

, the relative bubble height

$0.02\leqslant h/H \leqslant 0.05$

(where

$H$

is the height of the Rayleigh–Bénard cell), the bubble number

$40 \leqslant n \leqslant 144$

and their spatial distribution. In all cases, asymmetric temperature profiles are observed, which we quantitatively explain based on the heat flux conservation at each horizontal section. We further propose the idea of using an equivalent single-phase set-up to mimic the system with attached bubbles. Based on this equivalence, we can calculate the heat transfer. Without introducing any free parameter, the predictions for the Nusselt number, the upper and lower thermal boundary layer thicknesses and the mean centre temperature agree well with the numerical results. Finally, our predictions also work for the cases with much larger

$\mbox{Pr}$

(e.g.

$400$

), which indicates that our results can also be applied to predict the mass transfer in water electrolysis with bubbles attached to the electrode surface or in catalysis.
Vitamin B12 and/or folic acid supplementation on linear growth: a 6-year follow-up study of a randomised controlled trial in early childhood in North India
Authors: Taneja Sunita , Chowdhury Ranadip , Kvestad Ingrid , Bhandari Nita , Strand Tor A.
Published: July 2022

Folate and vitamin B12 are essential for growth. Our objective was to estimate their long-term effects on linear growth in North Indian children. This is a follow-up study of a factorial designed, double-blind, randomised, placebo-controlled trial in 1000 young children. Starting at 6–30 months of age, we gave folic acid (approximately 2 RDA), vitamin B12 (approximately 2 RDA), both vitamins or a placebo daily for 6 months. Six years after the end of supplementation, we measured height in 791 children. We used the plasma concentrations of cobalamin, folate and total homocysteine to estimate vitamin status. The effect of the interventions, the association between height-for-age z-scores (HAZ) and baseline vitamin status, and the interactions between supplementation and baseline status were estimated in multiple regression models. Mean (sd) age at follow-up was 7·4 (0·7) years (range 6 to 9 years). There was a small, non-significant effect of vitamin B12 on linear growth and no effect of folic acid. We observed a subgroup effect of vitamin B12 supplementation in those with plasma cobalamin concentration < 200 pmol/l (Pfor interaction = 0·01). The effect of vitamin B12 supplementation in this group was 0·34 HAZ (95 % CI 0·11, 0·58). We found an association between cobalamin status and HAZ in children not given vitamin B12 (Pfor interaction = 0·001). In this group, each doubling of the cobalamin concentration was associated with 0·26 (95 % CI 0·15, 0·38) higher HAZ. Suboptimal vitamin B12 status in early childhood seemingly limits linear growth in North Indian children.
INTERNATIONAL LAW BEFORE UNITED KINGDOM COURTS: A QUIET REVOLUTION
Authors: Lloyd-Jones Lord
Published: July 2022

In the 36 years since Francis Mann published Foreign Affairs in English Courts, the engagement of the United Kingdom courts with issues of international law has greatly increased. This article addresses the reasons underlying this trend and identifies four key developments: first, the nature of international law has evolved to embrace individuals as subjects; second, the Human Rights Act 1998 has had a profound influence, often requiring domestic courts to rule on matters of international law in order to give effect to the European Convention on Human Rights; third, in recent decades there has been a growing willingness on the part of courts in the United Kingdom to address and investigate the conduct of foreign States and issues of public international law; and fourth, these developments have been accompanied by a shift in attitudes to the relationship between customary international law and the common law.
Earnings Growth and Acquisition Returns: Do Investors Gamble in the Takeover Market?
Authors: Liu Tingting , Tu Danni
Published: July 2022

We document a strong positive initial market reaction to merger announcements from bidders with either large earnings growth or significant earnings decline, relative to those with neutral earnings change, reflecting a U-shaped pattern between bidders’ earnings growth and announcement returns. However, the higher initial returns for bidders with earnings decline subsequently reverse, whereas the higher returns for bidders with high growth do not. We further show that the return patterns are driven by a tendency for retail investors to gamble that merger and acquisition deals initiated by poorly performing bidders will generate high synergies.
Access to Finance and Technological Innovation: Evidence from Pre-Civil War America
Authors: Mao Yifei , Wang Jessie Jiaxu
Published: July 2022

This article provides new evidence on how access to finance affects technological innovation and establishes the role of labor practices in shaping this relation. We exploit a unique setting, pre-Civil War America, where staggered adoption of free banking laws across states encouraged bank entry, and variation in the use of exploited workers in agriculture generated differences in producers’ demands for labor-saving technologies. Results show that access to finance spurred innovation; the positive effect on agricultural innovation diminished with labor exploitation. We establish the causal role of labor exploitation using the 1850s cholera pandemic and the influx of Irish immigrants.
Women amid the COVID-19 pandemic: Self-protection through the behavioral immune system
Authors: Troisi Alfonso
Published: July 2022

Studies of the activation of the behavioral immune system triggered by the coronavirus disease-2019 pandemic have demonstrated that evolutionary explanations of individual differences in self-protection should not be based only on parental investment and sexual selection theory. An evolutionary model must also incorporate individual differences that arise within each sex as a result of life history strategies and attachment patterns.
Staying alive includes adaptations for catalyzing cooperation
Authors: Cassar Alessandra
Published: July 2022

The target article interprets women's lower competitiveness than men's as evidence of adaptation to help women avoid physical conflicts and stay alive. This commentary advances the additional hypothesis that strategically suppressing competitiveness, thus signaling egalitarian intentions, could be an adaptation to catalyze cooperative behavior from males and females, turning natural competitors (other women) into allies and men into supportive partners.
The pregnancy compensation hypothesis, not the staying alive theory, accounts for disparate autoimmune functioning of women around the world
Authors: O'Mara Kunz Erin M. , Goodnight Jackson A. , Wilson Melissa A.
Published: July 2022

The pregnancy compensation hypothesis provides a mechanistic explanation for the evolution of sex differences in immune system functioning, the excess of women experiencing autoimmune disease, and why this is observed only in industrialized nations; none of which can be explained by the staying alive theory, as proposed by the authors of the target article.
Psychological and behavioral implications of self-protection and self-enhancement
Authors: Tice Dianne M. , Baumeister Roy F. , Sedikides Constantine
Published: July 2022

Self-protection can have psychological and behavioral implications. We contrast them with the implications of a self-enhancement strategy. Both self-enhancement and self-protection have costs and benefits as survival strategies, and we identify some of the emotional, cognitive, and behavioral tradeoffs associated with the differential preferences for each strategy. New analyses on a large existing data set confirm the target article's hypothesis that women are more attuned than men to potential negative consequences of innovations.
Hertzian and adhesive plane models of contact of two inhomogeneous elastic bodies
Authors: ANTIPOV Y. A. , MKHITARYAN S. M.
Published: July 2022

Previous study of contact of power-law graded materials concerned the contact of a rigid body (punch) with an elastic inhomogeneous foundation whose inhomogeneity is characterised by the Young modulus varying with depth as a power function. This paper models Hertzian and adhesive contact of two elastic inhomogeneous power-law graded bodies with different exponents. The problem is governed by an integral equation with two different power kernels. A nonstandard method of Gegenbauer orthogonal polynomials for its solution is proposed. It leads to an infinite system of linear algebraic equations of a special structure. The integral representations of the system coefficients are evaluated, and the properties of the system are studied. It is shown that if the exponents coincide, the infinite system admits a simple exact solution that corresponds to the case when the Young moduli are different but the exponents are the same. Formulas for the length of the contact zone, the pressure distribution and the surface normal displacements of the contacting bodies are obtained in the form convenient for computations. Effects of the mismatch in the Young moduli exponents are studied. A comparative analysis of the Hertzian and adhesive contact models clarifies the effects of the surface energy density on the contact pressure, the contact zone size and the profile of the contacting bodies outside the contact area.
Manual versus Mechanical Delivery of High-Quality Cardiopulmonary Resuscitation on a River-Based Fire Rescue Boat
Authors: Manoukian Martin A.C. , Tancredi Daniel J. , Linvill Matthew T. , Wynia Elisabeth H. , Beaver Brianna , Rose John S. , Mumma Bryn E.
Published: July 2022

Objectives:

Studies have demonstrated the efficacy of mechanical devices at delivering high-quality cardiopulmonary resuscitation (HQ-CPR) in various transport settings. Herein, this study investigates the efficacy of manual and mechanical HQ-CPR delivery on a fire rescue boat.

Methods:

A total of 15 active firefighter-paramedics were recruited for a prospective manikin-based trial. Each paramedic performed two minutes manual compression-only CPR while navigating on a river-based fire rescue boat. The boat was piloted in either a stable linear manner or dynamic S-turn manner to simulate obstacle avoidance. For each session of manual HQ-CPR, a session of mechanical HQ-CPR was also performed with a LUCAS 3 (Stryker; Kalamazoo, Michigan USA). A total of 60 sessions were completed. Parameters recorded included compression fraction (CF) and the percentage of compressions with correct depth >5cm (D%), correct rate 100-120 (R%), full release (FR%), and correct hand position (HP%). A composite HQ-CPR score was calculated as follows: ((D% + R% + FR% + HP%)/4) * CF%). Differences in magnitude of change seen in stable versus dynamic navigation within study conditions were evaluated with a Z-score calculation. Difficulty of HQ-CPR delivery was assessed utilizing the Borg Rating of Perceived Exertion Scale.

Results:

Participants were mostly male and had a median experience of 20 years. Manual HQ-CPR delivered during stable navigation out-performed manual HQ-CPR delivered during dynamic navigation for composite score and trended towards superiority for FR% and R%. There was no difference seen for any measured variable when comparing mechanical HQ-CPR delivered during stable navigation versus dynamic navigation. Mechanical HQ-CPR out-performed manual HQ-CPR during both stable and dynamic navigation in terms of composite score, FR%, and R%. Z-score calculation demonstrated that manual HQ-CPR delivery was significantly more affected by drive style than mechanical HQ-CPR delivery in terms of composite HQ-CPR score and trended towards significance for FR% and R%. Borg Rating of Perceived Exertion was higher for manual CPR delivered during dynamic sessions than for stable sessions.

Conclusion:

Mechanical HQ-CPR delivery is superior to manual HQ-CPR delivery during both stable and dynamic riverine navigation. Whereas manual HQ-CPR delivery was worse during dynamic transportation conditions compared to stable transport conditions, mechanical HQ-CPR delivery was unaffected by drive style. This suggests the utility of routine use of mechanical HQ-CPR devices in the riverine patient transport setting.
A Palette for a Prince: The Colours in the Shahnamah for Muhammad Juki
Authors: PORTER CHERYL
Published: July 2022

The Shahnamah (RAS 239) copied for the Timurid prince, Muhammad Juki (1402–1445) in Herat, has long been considered one of the finest surviving, illustrated Timurid manuscripts. It was presented to the RAS in 1834 by Lieutenant Colonel Doyle (1787–1848), but attracted little scholarly attention until Barbara Brend published her monograph in 2010. The manuscript contains 31 exquisite miniature paintings, two of which (fol. 430v and fol. 531r) were added later during the Mughal period (1526–1761). This article will examine the sumptuous, jewel-like colours employed to depict scenes from the epic and the metals, pigments, and dyes from which they were derived. Precious metals and organic colours made from plants such as indigo and lac extracted from female insects are examined in detail: the methods of their production and extraction, the techniques used for their application, their commercial value, and the prestige they afforded their patrons all contribute to an understanding of what constituted the miniature painters' palette in the Timurid period.
Cascading expert failure
Authors: Murphy Jon
Published: July 2022

Recent research has shown how experts may fail in their duty as advisors by providing advice that leads to a worse outcome than that anticipated by the user of expert opinion. However, those models have focused on the immediate effects of the failure on experts and nonexperts. Using a cascading network failure model, I show how expert failure can cascade throughout multiple sectors, even those not necessarily purchasing the expert opinion. Consequently, even relatively small failures end up having outsized aggregate effects. To provide evidence of my theory, I look at two case studies of COVID expert advice to show how one seemingly minor failure ended up contributing to the pandemic. I conclude with a discussion on institutional frameworks that can prevent such cascades.
The Soviet Steppe: Transformations and Imaginaries—Introduction
Authors: Bichsel Christine , Filep Ekaterina , Obertreis Julia
Published: July 2022

We dedicate this special issue to the memory of Maya Karin Peterson, who passed away unexpectedly and tragically on June 16, 2021. We, the editors and authors of this special issue, are still shocked and deeply saddened by this terrible loss. We can only seek some small solace in the fact that her highly original and relevant contribution on the Eurasian steppe was ready for publication when her life ended so abruptly. We are grateful to the editors of the Slavic Review, who kindly agreed to publish her paper posthumously.
Marriage, Gender and Demographic Change: Managing Fertility in State-Socialist Poland
Authors: Jarska Natalia , Ignaciuk Agata
Published: July 2022

This paper explores fertility management practices in state-socialist Poland and investigates post-war demographic change through the lenses of gender and modernization. Using personal narratives from oral histories and memoirs, we examine reproductive decision-making processes from the 1940s to the 1980s, focusing on motivations, norms, and the means employed to achieve desired family size. Our analysis reveals the ambiguous nature of both modernization and women's emancipation in regard to reproduction. We argue that acceptance of the two-child model and the need to effectively manage fertility increased in Poland through the second half of the twentieth century, but was highly dependent on levels of spousal communication and equality. Personal narratives demonstrate how social pressure shaped women's reproductive choices, and how at times these choices were considerably limited by male violence and domination. As our analysis shows, gender relations in marriage and the modernization of fertility management in state-socialist Poland were deeply interrelated.
A prediction-focused approach to personality modeling
Authors: Lavi Gal , Rosenblatt Jonathan , Gilead Michael
Published: July 2022

In the current study, we set out to examine the viability of a novel approach to modeling human personality. Research in psychology suggests that people’s personalities can be effectively described using five broad dimensions (the Five-Factor Model; FFM); however, the FFM potentially leaves room for improved predictive accuracy. We propose a novel approach to modeling human personality that is based on the maximization of the model’s predictive accuracy. Unlike the FFM, which performs unsupervised dimensionality reduction, we utilized a supervised machine learning technique for dimensionality reduction of questionnaire data, using numerous psychologically meaningful outcomes as data labels (e.g., intelligence, well-being, sociability). The results showed that our five-dimensional personality summary, which we term the “Predictive Five” (PF), provides predictive performance that is better than the FFM on two independent validation datasets, and on a new set of outcome variables selected by an independent group of psychologists. The approach described herein has the promise of eventually providing an interpretable, low-dimensional personality representation, which is also highly predictive of behavior.
Budd-Chiari-like pathology in dolphins
Authors: Fernandez Antonio , Jepson Paul D. , Diaz-Delgado Josue , de Quiros Yara Bernaldo , Sierra Eva , Mompeo Blanca , Vela Ana Isabel , Di Guardo Giovanni , Suarez-Santana Cristian , de los Monteros Antonio Espinosa , Herraez Pedro , Andrada Marisa , Caballero Maria Jose , Rivero Miguel , Consoli Francesco , Castro-Alonso Ayoze , Quesada-Canales Oscar , Arbelo Manuel
Published: July 2022

Nearly two decades ago, pathologic examination results suggested that acoustic factors, such as mid-frequency active naval military sonar (MFAS) could be the cause of acute decompression-like sickness in stranded beaked whales. Acute systemic gas embolism in these whales was reported together with enigmatic cystic liver lesions (CLL), characterized by intrahepatic encapsulated gas-filled cysts, tentatively interpreted as “gas-bubble” lesions in various other cetacean species. Here we provide a pathologic reinterpretation of CLL in odontocetes. Among 1,200 cetaceans necropsied, CLL were only observed in four striped dolphins (Stenella coeruleoalba), with a low prevalence (2%, N = 179). Together, our data strongly suggest that CLL are the result of the combination of a pre-existing or concomitant hepatic vascular disorder superimposed and exacerbated by gas bubbles, and clearly differ from acute systemic gas embolism in stranded beaked whales that is linked to MFAS. Budd-Chiari-like syndrome in dolphins is hypothesized based on the present pathologic findings. Nonetheless, further researched is warranted to determine precise etiopathogenesis(es) and contributing factors for CLL in cetaceans.
Comparison between two- and three-dimensional methods for offset measurements after total hip arthroplasty
Authors: Tone Shine , Hasegawa Masahiro , Naito Yohei , Wakabayashi Hiroki , Sudo Akihiro
Published: July 2022

The aim of this study was to compare acetabular offset, femoral offset, and global offset measurements obtained after total hip arthroplasty (THA) between a two-dimensional (2D) method and a three-dimensional (3D) method. The subjects were 89 patients with unilateral osteoarthritis who underwent primary THA at our institution. Acetabular, femoral, and global offsets were measured by each of the 2D and 3D methods in native and implanted hips. In native hips, mean acetabular, femoral, and global offsets were 32.4 ± 3.3, 32.7 ± 4.5, 65.1 ± 5.7 mm, respectively, by the 2D method, and 32.3 ± 3.1, 38.1 ± 4.0, 70.4 ± 4.9 mm, respectively, by the 3D method. In implanted hips, mean acetabular, femoral, and global offsets were 27.6 ± 4.1, 33.8 ± 7.8, 61.4 ± 8.5 mm, respectively, by the 2D method, and 27.6 ± 3.9, 41.8 ± 6.2, 69.4 ± 7.2 mm, respectively, by the 3D method. There was significant difference in femoral and global offsets between the 2D and 3D methods in both native and implanted hips. Comparison of the 2D and 3D methods for evaluation of acetabular, femoral, and global offsets after THA clarified the usefulness and accuracy of the 3D method.
Hexagonal boron nitride (h-BN) memristor arrays for analog-based machine learning hardware
Authors: Xie Jing , Afshari Sahra , Sanchez Esqueda Ivan
Published: July 2022

Recent studies of resistive switching devices with hexagonal boron nitride (h-BN) as the switching layer have shown the potential of two-dimensional (2D) materials for memory and neuromorphic computing applications. The use of 2D materials allows scaling the resistive switching layer thickness to sub-nanometer dimensions enabling devices to operate with low switching voltages and high programming speeds, offering large improvements in efficiency and performance as well as ultra-dense integration. These characteristics are of interest for the implementation of neuromorphic computing and machine learning hardware based on memristor crossbars. However, existing demonstrations of h-BN memristors focus on single isolated device switching properties and lack attention to fundamental machine learning functions. This paper demonstrates the hardware implementation of dot product operations, a basic analog function ubiquitous in machine learning, using h-BN memristor arrays. Moreover, we demonstrate the hardware implementation of a linear regression algorithm on h-BN memristor arrays.
Solution structure of recombinant Pvfp-5β reveals insights into mussel adhesion
Authors: Morando Maria Agnese , Venturella Francesca , Sollazzo Martina , Monaca Elisa , Sabbatella Raffaele , Vetri Valeria , Passantino Rosa , Pastore Annalisa , Alfano Caterina
Published: July 2022

Some marine organisms can resist to aqueous tidal environments and adhere tightly on wet surface. This behavior has raised increasing attention for potential applications in medicine, biomaterials, and tissue engineering. In mussels, adhesive forces to the rock are the resultant of proteinic fibrous formations called byssus. We present the solution structure of Pvfp-5β, one of the three byssal plaque proteins secreted by the Asian green mussel Perna viridis, and the component responsible for initiating interactions with the substrate. We demonstrate that Pvfp-5β has a stably folded structure in agreement with the presence in the sequence of two EGF motifs. The structure is highly rigid except for a few residues affected by slow local motions in the µs-ms time scale, and differs from the model calculated by artificial intelligence methods for the relative orientation of the EGF modules, which is something where computational methods still underperform. We also show that Pvfp-5β is able to coacervate even with no DOPA modification, giving thus insights both for understanding the adhesion mechanism of adhesive mussel proteins, and developing of biomaterials.
Specific intracellular signature of SARS-CoV-2 infection using confocal Raman microscopy
Authors: Salehi Hamideh , Ramoji Anuradha , Mougari Said , Merida Peggy , Neyret Aymeric , Popp Jurgen , Horvat Branka , Muriaux Delphine , Cuisinier Frederic
Published: July 2022

SARS-CoV-2 infection remains spread worldwide and requires a better understanding of virus-host interactions. Here, we analyzed biochemical modifications due to SARS-CoV-2 infection in cells by confocal Raman microscopy. Obtained results were compared with the infection with another RNA virus, the measles virus. Our results have demonstrated a virus-specific Raman molecular signature, reflecting intracellular modification during each infection. Advanced data analysis has been used to distinguish non-infected versus infected cells for two RNA viruses. Further, classification between non-infected and SARS-CoV-2 and measles virus-infected cells yielded an accuracy of 98.9 and 97.2 respectively, with a significant increase of the essential amino-acid tryptophan in SARS-CoV-2-infected cells. These results present proof of concept for the application of Raman spectroscopy to study virus-host interaction and to identify factors that contribute to the efficient SARS-CoV-2 infection and may thus provide novel insights on viral pathogenesis, targets of therapeutic intervention and development of new COVID-19 biomarkers.
Metamorphic densification can account for the missing felsic crust of the Greater Indian continent
Authors: Wang Yang , Zhang Lifei , Li Zhong-Hai
Published: July 2022

The long-duration, fast convergence, and imbalance of crustal mass in the India-Asia collisional system challenge the classical rules of continental dynamics. Here, we calculate the mass deficit of felsic crust in Greater India indicating ~20–47% of the felsic crust is missing during collision. Phase equilibria modeling and density calculations demonstrate the pressure-temperature-dependent density of felsic crust is denser than the surrounding mantle at P > 7–8 GPa. Integrated petrological-thermo-mechanical models and analytical studies of the slab-pull forces confirm the Greater Indian continent with its felsic crust can subduct spontaneously under its own negative buoyancy when it is dragged to >170 km by the preceding oceanic slab. The great slab-pull force, induced by the negative buoyancy of subducted crust below 170 km, not only contributes to the long-lasting fast convergence between India and Asia but also explains the crustal mass imbalance during the Himalayan orogeny.
Authigenic clay mineral evidence for restricted, evaporitic conditions during the emergence of the Ediacaran Doushantuo Biota
Authors: Han Shujun , Lӧhr Stefan C. , Abbott April N. , Baldermann Andre , Voigt Martin , Yu Bingsong
Published: July 2022

The Ediacaran Period witnessed major environmental change and an expansion of eukaryotic life following the Marinoan glaciation. The Doushantuo Formation of south China has furnished much of our understanding of Earth System and biosphere evolution during this period, but its depositional setting–marine or non-marine–is still debated. Here we conduct mineralogical, petrographic and geochemical analyses of samples from the lower Doushantuo Formation in order to determine the origin of saponite clay minerals which are abundant in this interval. We find that the morphology and distribution of the saponite clays suggest they are of pre-compaction, authigenic origin. We infer that the lower Doushantuo sediments were deposited in a restricted, mildly evaporitic lagoonal basin, offering additional constraints on the environmental setting into which metazoan life emerged. Further, our findings confirm that Ediacaran seawater favored reverse weathering, with marine clay formation likely representing an important sink for various elements during the Precambrian.
Spin reorientation transition driven by polaronic states in Nd2CuO4
Authors: Banik Soma , Vijay Kritika , Paul Suvankar , Mansuri Najnin , Shukla D. K. , Srivastava S. K. , Sagdeo Archna , Kumar Kranti , Tripathi Shilpa , Jha S. N.
Published: July 2022

We show that the spin reorientation transitions in Nd2CuO4 are associated with the polaronic states and depend on the electronic interactions between the bulk and the surface.
Multifunctional CeO2incorporated Fe2O3anchored on a rich porous structured carbon backbone for supercapacitors and adsorption of acid orange II
Authors: Zhang Hang , Xia Lijuan , Tang Jianping , Li Yuan , Wang Lei , Ouyang Chuying , Zhong Shengliang
Published: July 2022

Multifunctional porous CeO2–Fe2O3/C for supercapacitor electrode materials and organic dye acid orange II adsorption obtained by hydrothermal and N2atmosphere pyrolysis of Ce–Fe coordination polymers formed from Ce and 1,1′-dipentadecadienoic acid.
Comparing Measures From Computer-Administered and Examiner-Administered Narrative Retells in Spanish: A Pilot Study
Authors: Heilmann John , Finneran Denise , Moyle Maura
Published: July 2022

Purpose:

Narrative language sample analysis (LSA) is a recommended best practice for the assessment of monolingual and bilingual children. With business-as-usual narrative LSA, examiners are actively involved in all aspects of the elicitation. Software advancements have shown multiple benefits of computer-administered language assessments, some of which may be beneficial for narrative assessments, particularly for bilingual children. The goal of this pilot study was to test the feasibility of computer-administered narrative retells in bilingual children.

Method:

Ten English–Spanish bilingual children, kindergarten to fourth grade, completed two narrative retells using wordless picture books (
Frog Goes to Dinner
and
Frog on His Own
) in two conditions: examiner-administered and computer-administered. Five narrative measures were generated from these 20 transcripts.

Results:

Significant, strong correlations were observed between the two elicitation methods for four of the five measures. We completed a series of Wilcoxon signed-ranks tests and found no significant differences in measures across the elicitation methods. Follow-up descriptive analyses revealed few large differences across elicitation methods for the individual participants.

Conclusion:

This study provides preliminary evidence on the use of a computer-administered narrative procedure and motivates further research on the method to confirm its validity and to document its effectiveness within clinical practice.

Supplemental Material:

https://doi.org/10.23641/asha.20346648
Spherical harmonic decomposition and interpretation of the shapes of the small Saturnian inner moons
Authors: Rambaux N. , Lainey V. , Cooper N. , Auzemery L. , Zhang Q. F.
Published: July 2022

Context. The Cassini-Huygens space mission made a series of observations of Saturn’s small satellites during its grand finale stage. These measurements were performed in order to study the shape, geology, and surface composition of the small satellites as well as to study the impact of the environment, in particular the rings, on these small bodies.

Aims. The purpose of this study is to focus on the shape analysis of the small Saturnian satellites in order to describe their global figure and large-scale topography, as well as to deduce fundamental quantities, gravity field, and amplitude of the diurnal libration by assuming that the bodies are homogeneous.

Methods. We used two approaches in this study. On the one hand, we directly exploited the Cassini images of the small satellites by performing limb measurements and deducing a confidence interval on the shape measurements. On the other hand, we used previously published shape models which combine limb measurements and control points. These shape models were then decomposed and described in spherical harmonics.

Results. We found that the shape of the small satellites can be described with a confidence interval between 50 and 150 m. The low degree in spherical harmonics (degree 2) indicated that Telesto, Pandora, Pan, Janus, and Helene have a degree 2 shape close to the Omega sequence, which was defined recently, where the potential is constant along a meridian perpendicular to the longest axis. The degree 2 shape of Epimetheus, on the other hand, is close to the Roche sequence. In contrast, Prometheus, Calypso, and Atlas are in the Low-Brown region. The root mean square spectrum and spherical harmonic maps then allowed us to describe the topography of the satellites, and in particular to highlight equatorial ridges for some satellites including Daphnis. Finally, our estimates of the libration amplitude in the homogeneous case provide values in agreement with previously published librational measurements for Epimetheus while highlighting the proximity of the resonance for Epimetheus, Pandora, and Prometheus.

Conclusions. The high resolution images of the internal satellites have allowed us to describe the geology and the geophysics of these bodies. Future comparison of these amplitudes with new librational measurements deduced, for example, by the astrometric method, will allow us to obtain information on the internal structure of these bodies. Similar studies could be carried out on the internal satellites of Jupiter using images from the Europa Clipper (NASA) or JUICE (ESA) missions.
Radio, sport et culture : quand l’écriture radiophonique construit un discours culturel au-delà des résultats et des performances
Authors: Equoy Hutin Séverine
Published: July 2022

Dans le contexte où la médiatisation du sport ne se limite plus aux productions médiatiques destinées à assurer la retransmission d’un évènement sportif ou à commenter l’actualité sportive, cette contribution s’intéresse à trois émissions radiophoniques (chroniquesEsprit sport, France Inter etL’âme Olympique, France Info et le magazineL’œil du tigre, France Inter) qui participent autrement de l’inscription du sport dans la culture populaire. C’est en menant une approche sémiodiscursive et argumentative de l’écriture radiophonique de ces émissions que nous proposons d’interroger et d’analyser les modes de construction d’une culture du sport au-delà de la pratique physique et des émissions qui lui sont traditionnellement consacrées (retransmission, multiplex, talkshow dédié à l’actualité sportive). À travers ces trois études de cas, nous montrons que ces productions radiophoniques scénographient et mettent le sport en relation avec d’autres problématiques sociétales contemporaines. L’écriture radiophonique – et quelques-uns de ces procédés – problématisent et décloisonnent le sport pour construire un discours culturel et instituer le sport en bien culturel commun.
Krankheit und Genesung: Der verschlungene Weg vom Patienten zum Genesungshelfer
Authors: Gauger Klaus
Published: July 2022

Das Leben verläuft manchmal in verschlungenen Pfaden – so auch bei unserem Autor: Mit 28 Jahren erhielt er die Diagnose paranoide Schizophrenie, zahlreiche gesundheitliche und berufliche Rückschläge säumten seinen Weg. Doch seine Erfahrungen eröffneten ihm auch neue Perspektiven: Seit vier Jahren arbeitet er als Genesungsbegleiter auf einer Psychose-Station und unterstützt Betroffene bei ihrem Heilungsprozess.
Eingreifen, bevor es sich zuspitzt
Authors: Pritschke Maik
Published: July 2022

Eine klare Haltung und Strategie in Einrichtungen und Kliniken zum Thema Gewalt und Aggression sind wichtig – und Führungsaufgabe. Oftmals sind Präventions- und Hilfsangebote nicht ausreichend bekannt oder überhaupt nicht vorhanden.
Hoffnung geben
Authors: Franke-Luderer Daniela
Published: July 2022

Um Menschen in schweren psychischen Krisen zu unterstützen, ist es sinnvoll, Psychiatrie-Erfahrene in die Versorgung einzubeziehen. Welchen Weg die Genesungsbegleitenden durchlaufen haben, um anderen Betroffenen Hoffnung geben zu können, erfahren Sie im CNE Schwerpunkt.
Large eddy simulations of reacting and non-reacting transcritical fuel sprays using multiphase thermodynamics
Authors: Fathi Mohamad , Hickel Stefan , Roekaerts Dirk
Published: July 2022

We present a novel framework for high-fidelity simulations of inert and reacting sprays at transcritical conditions with highly accurate and computationally efficient models for complex real-gas effects in high-pressure environments, especially for the hybrid subcritical/supercritical mode of evaporation during the mixing of fuel and oxidizer. The high-pressure jet disintegration is modeled using a diffuse interface method with multiphase thermodynamics, which combines multi-component real-fluid volumetric and caloric state equations with vapor–liquid equilibrium calculations for the computation of thermodynamic properties of mixtures at transcritical pressures. Combustion source terms are evaluated using a finite-rate chemistry model, including real-gas effects based on the fugacity of the species in the mixture. The adaptive local deconvolution method is used as a physically consistent turbulence model for large eddy simulation (LES). The proposed method represents multiphase turbulent fluid flows at transcritical pressures without relying on any semi-empirical breakup and evaporation models. All multiphase thermodynamic model equations are presented for general cubic state equations coupled with a rapid phase-equilibrium calculation method that is formulated in a reduced space based on the molar specific volume function. LES results show a very good agreement with available experimental data for the reacting and non-reacting engine combustion network benchmark spray A at transcritical operating conditions.