bluuebunny/crossref_metadata_2025 huggingface dataset:
Using volunteers to improve access to community rehabilitation in palliative care: the St Christopher's Living Well at Home Team
Authors: Preston Gail , Rampes Sanketh , Bayly Joanne , Rice Helena Talbot , Angelova Ralitsa , Richardson Heather , Maddocks Matthew
Published: September 2023

Background

UK hospices often provide outpatient rehabilitation services for people with advanced progressive illness. However, some people are unable to travel, leading to inequity in rehabilitation access.

Objectives

The Living Well at Home Team (LWAHT) at St Christopher's Hospice aimed to evaluate whether using volunteers to support rehabilitation in peoples’ homes improved the reach of rehabilitation for people living in underserved localities and if it supported people to optimise their functional independence.

Methods

This service improvement project evaluated hospice rehabilitation uptake during the implementation of volunteer-supported community rehabilitation. Following assessment by an LWAHT therapist, eligible people were matched with a trained volunteer who supported four to eight rehabilitation sessions in the person's home. The evaluation assessed uptake of the rehabilitation sessions. Mobility, wellbeing, and goal attainment outcomes were assessed by the Life-Space Assessment (LSA), General Health Questionnaire (GHQ), and Goal Attainment Scale (GAS), respectively.

Results

In the first year, 183 patients were referred to the LWAHT; 123 were assessed and 96 received rehabilitation including 56 who were matched with a volunteer. Following volunteer support, patients reported significant improvements in mobility [LSA median 20 (IQR, 3.5–27.8)], general health [GHQ −2 (−5.25 to 0)], and achievement of goals [GAS T-score +8 (0–18.4)].

Conclusions

It was feasible to support community rehabilitation using hospice volunteers for people with advanced progressive illness. The LWAHT service also increased the uptake of hospice centre-based rehabilitation. Further work should test efficacy and identify patients requiring additional professional input.

Key message

This is the first known study reporting on the use of trained rehabilitation volunteers to extend the reach of hospice rehabilitation services. People with limited access to the hospice, because of geographical location or personal circumstances, valued and benefited from tailored rehabilitation supported by the volunteers in their own homes.
The induction effect: why the rebound effect is only half the story of technology's failure to achieve sustainability
Authors: Lange Steffen , Frick Vivian , Gossen Maike , Pohl Johanna , Rohde Friederike , Santarius Tilman
Published: September 2023

The concept of the rebound effect is important in understanding the limits to how much technological efficiency improvements can reduce energy and resource consumption. However, due to the concept's focus on efficiency, it neglects other environmental implications of technological change. We use the term “induction effect” to grasp additional important mechanisms stemming from new technologies. We define an induction effect as an increase in the level of energy or resource consumption that was caused or enabled by the emergence of “new options” arising from technological change. Our investigation of three cases of new technologies - online consumption, smart homes, and pace of life - shows how including both rebound and induction effects into the analysis helps in understanding the relationship between technological change and energy and resource consumption. Integrating induction effects into the analysis underpins the importance of sufficiency as a strategy for sustainability and helps to develop comprehensive policy measures.
Clinical observation on the treatment of displaced distal radial and ulnar fractures in children by closed manipulation combined with splinting
Authors: Wang Guangwei , Huo Liwei , Xu Yidong , Dai Gerong , Yang Zhong , Hu Jianwei , Liu Weinian
Published: September 2023

Objective

The aim of this study was to investigate the clinical efficacy of closed manipulation combined with splinting in the treatment of displaced distal radial and ulnar fractures in children.

Methods

A total of 82 children with displaced fractures of the distal radial and ulnar segment who met the inclusion criteria and were treated as outpatients or inpatients in the orthopedic department of Guangzhou Orthopedic Hospital, from January 2016 to June 2022 were randomly divided into an observation group and a control group: 41 children in the observation group were treated with closed manipulation combined with splint fixation; 41 children in the control group were fixed with incisional repositioning elastic nails combined with internal plates. The Anderson efficacy grading, visual analog scale (VAS) score, fracture healing time, treatment cost, hospital days, and complications were observed and compared between the two groups.

Result

The efficacy was evaluated according to the Anderson forearm fracture efficacy evaluation criteria, and the results of statistical analysis showed no statistically significant differences between the two groups (P > 0.05). At 3 and 7 weeks after treatment, the VAS scores of children in both groups decreased (P < 0.05), and the VAS scores in the observation group were significantly lower than those in the control group (P < 0.05), indicating that the observation group had a significant advantage in the relief of pain after treatment. The fractures healed in both groups after treatment with the two different methods, and the difference in healing time between the two groups was not statistically significant (P > 0.05). The length of hospital stay, treatment cost, and complication ratio were significantly lower in the observation group than in the control group (P < 0.05).

Conclusion

In children with displaced fractures of the distal radial and ulnar segments, treatment by manual repositioning with external splinting can achieve satisfactory results with simple operation, low cost, short hospital stay, and few complications, which is especially suitable to be promoted in primary hospitals and has good social benefits.
First report on tick-borne pathogens detected in ticks infesting stray dogs near butcher shops
Authors: Ali Abid , Ullah Shafi , Numan Muhammad , Almutairi Mashal M. , Alouffi Abdulaziz , Tanaka Tetsuya
Published: September 2023

Public health is a major concern for several developing countries due to infectious agents transmitted by hematophagous arthropods such as ticks. Health risks due to infectious agents transmitted by ticks infesting butcher-associated stray dogs (BASDs) in urban and peri-urban regions have been neglected in several developing countries. To the best of the authors’ knowledge, this is the first study assessing public health risks due to ticks infesting BASDs in Pakistan’s urban and peri-urban areas. A total of 575 ticks (390 from symptomatic and 183 from asymptomatic BASDs) were collected from 117 BASDs (63 symptomatic and 54 asymptomatic); the ticks belonged to 4 hard tick species. A subset of each tick species’ extracted DNA was subjected to polymerase chain reaction (PCR) to amplify the 16S rDNA and cox1 sequences of the reported tick species, as well as bacterial and protozoal agents. The ticks’ 16S rDNA and cox1 sequences showed 99–100% identities, and they were clustered with the sequence of corresponding species from Pakistan and other countries in phylogenetic trees. Among the screened 271 ticks’ DNA samples, Anaplasma spp. was detected in 54/271 (19.92%) samples, followed by Ehrlichia spp. (n = 40/271, 14.76%), Rickettsia spp. (n = 33/271, 12.17%), Coxiella spp. (n = 23/271, 4.48%), and Hepatozoon canis (n = 9/271, 3.32%). The obtained sequences and phylogenetic analyzes revealed that the pathogens detected in ticks were Ehrlichia minasensis, Ehrlichia sp., Hepatozoon canis, Coxiella burnetii, Coxiella sp., Anaplasma capra, Anaplasma platys, Anaplasma sp., Rickettsia massiliae, “Candidatus Rickettsia shennongii” and Rickettsia aeschlimannii. Tick-borne pathogens such as E. minasensis, H. canis, A. capra, A. platys, and R. aeschlimannii, were detected based on the DNA for the first time in Pakistan. This is the first report on public health risks due to ticks infesting BASDs. These results not only provided insights into the occurrence of novel tick-borne pathogens in the region but also revealed initial evidence of zoonotic threats to both public health and domestic life.
First serological and molecular investigation of hepatitis E virus infection in dromedary camels in Algeria
Authors: Agabou Amir , Benaissa Mohamed Hocine , Bouasla Ilyes , De Sabato Luca , Hireche Sana , Ianiro Giovanni , Monini Marina , Di Bartolo Ilaria
Published: September 2023

Hepatitis E is an acute self-limited or fulminant infection in humans, caused by the hepatitis E virus (HEV). This member of the Hepeviridae family has been identified in a wide range of domestic and wild animals all over the world, with a possible transmission to humans through fecal oral route, direct contact and ingestion of contaminated meat products, making it one of the global zoonotic and public health major concerns. Since there is no monitoring program and a lack of data on HEV in animals in Algeria, the current preliminary survey has been undertaken to elucidate the exposure to the virus in camels at abattoirs of six southern provinces of Algeria. Two-hundred and eight sera/plasma were collected and analyzed (by double antigen sandwich ELISA) for the presence of total anti-HEV antibodies, among which 35.1% were positive, but no HEV RNA could be isolated from them (by two pan-HEV nested RT-PCR and broad range real-time reverse transcription RT-PCR). The univariate analysis showed significant associations (p < 0.05) between HEV seroprevalence and province of origin, age, and sex of camels, whereas the multivariable logistic regression analysis revealed a negative impact of camels’ age on it. The obtained results confirm that HEV infection is widespread established in the camelid population of Algeria.
How Do the Labour Force Characteristics Encounter COVID-19 Economic Consequences—A Canadian Experience
Authors: Gjipali Arsena , Karapici Valbona , Baci Nevila
Published: September 2023

This paper draws on a current international analysis of pandemic consequences in the labour market and on the way different segments have been impacted. The purpose is to provide a critical investigation of the facts and arguments regarding how and why the consequences of the same health epidemic are differently faced at an uneven socio-economic burden. The objectives are twofold: First, we aim to explore on an international level the inequality settings that COVID-19 has highlighted, focusing on the most affected economic pillars such as the labour market. Second, we provide an empirical analysis of the likelihood of Canadian labour force participants to be unemployed before and after COVID-19, as one of the measurable effects of the pandemic. We assess how the likelihood of the working-age population falling into the unemployment pool varies before, during and immediately after the pandemic restrictions ease, using Canadian Labour Force Survey microdata. The findings indicate that mainly immigrants and youth suffered the most, pointing out their probably higher participation in precarious jobs and calling for policy initiatives to fix the structural faults in the labour market.
Ammonia Cycling and Emerging Inorganic Secondary Aerosols from Arable Agriculture
Authors: Pohl Vivien , Gilmer Alan , Byers Vivienne , Cassidy John , Donnelly Aoife , Hellebust Stig , McGillicuddy Eoin J. , McGovern Eugene , O’Connor David J.
Published: September 2023

Air quality monitoring in Ireland is under the jurisdiction of the Environmental Protection Agency in compliance with the Gothenburg Protocol, EU/national legislation, and the National Clean Air Strategy. Secondary inorganic aerosols (SIAS) have been acknowledged as a key atmospheric pollutant, with serious public health impacts and no safe exposure threshold in place to date. Ammonia (NH3) emissions are linked to the secondary production of aerosols through atmospheric reactions occurring with acidic atmospheric components such as sulfuric, nitric, and hydrochloric acid. These reactions result in the formation of ammonium sulfate, ammonium nitrate and ammonium chloride, among others. Approximately 98% of NH3 emissions occurring in Ireland arise from agriculture, with minor contributions from transport and natural sources. A better understanding of NH3 emissions and SIA formation can be achieved through monitoring emissions at the source level. Additionally, mitigation strategies with a more thorough understanding of NH3 dynamics at the source level and consequential SIA formation allow for more efficient action. This project monitored ambient NH3 and SIA on two selected arable agricultural sites and a control site in a rural site close to Dublin on the east coast of Ireland to establish emission levels. Meteorological factors affecting emissions and SIA formation were also measured and cross-correlated to determine micro-meteorological effects. Monitoring at the agricultural sites observed ambient NH3 concentrations ranging from 0.52 µg m−3 to 1.70 µg m−3, with an average of 1.45 µg m−3. At the control site, ambient NH3 measured concentrations ranged from 0.05 µg m−3 to 1.76 µg m−3 with an average of 0.516 µg m−3. Aerosol NH4+ ranged from 0.03 µg m−3 to 1.05 µg m−3 with an average concentration of 0.27 µg m−3 at the agricultural site. The potential effects of meteorological conditions and the implications for the effects of these emissions are discussed, with recommendations to aid compliance with the National Emissions Ceiling and the National Clean Air Strategy (Directive 2001/81/EC).
Removal of N-Terminal Peptide Impacts Structural Aspects of an IgE-Reactive Recombinant Der p 5
Authors: Vieira Camilo , Silva Raphael , Silveira Elisânia , Fernandes Antônio , Jaramillo-Hernández Dumar , Garcés Luis , Fonseca Larissa , Machado Bruna , Fernandes Jamille , Pinheiro Gabriela , Cruz Álvaro , Ferreira Fatima , Cooper Philip , Pacheco Luis , Alcantara-Neves Neuza , Pinheiro Carina , da Silva Eduardo
Published: September 2023

(1) Background: Modification of the structural elements of allergens is widely used in the field of allergies. The goal of the present research was to express, purify, and characterize the shortened recombinant group 5 allergen of Dermatophagoides pteronyssinus (rDer p 5). (2) Methods: rDer p 5 storage stability and aggregation capacity were explored through in silico analysis, dynamic light scattering (DLS), and SDS-PAGE. Serum IgE reactivity and cytokine amount were investigated in sera or cell culture supernatants through ELISA, MULTIPLEX®, and Western blot analysis using sera from sensitized humans from Brazil, Colombia, and Ecuador. (3) Results: Dimeric rDer p 5 was detected through native PAGE, and this result was confirmed by data from DLS. The protein was thermically stable, as it did not degrade at 4 °C for 21 days. The shortened rDer p 5 was classified as a major IgE allergen in Brazil and Colombia, but minor in Ecuador. IL-13, IL-10, IL-1β, and IL-6 were significantly elevated in the sera of rDer p 5-reactive patients. The same cytokines plus IL-5 were more secreted by human cells upon rDer p 5 stimulation. (4) Conclusions: N-terminal peptide deletion led to a higher rDer p 5 folding stability, which, even though dimeric, was an IgE-reactive protein. Therefore, rDer p 5 could be used for molecular diagnostic applications or as backbone for hypoallergen design.
Multi-Mode Lithium-Ion Battery Balancing Circuit Based on Forward Converter with Resonant Reset
Authors: Zong Yanliang , Li Kun , Wang Qing , Meng Jiaheng
Published: September 2023

A multi-mode active balancing circuit based on a forward converter with resonant reset is proposed to deal with unbalanced states of lithium-ion battery packs. The balancing circuit utilizes the forward converter, enabling high-power balancing. SPST relays are selected to constitute the switching matrix, and the proposed balancing circuit completes the connection of serial battery clusters to the main circuit by controlling the SPST relays, realizing the Multi-Cell-to-Multi-Cell (MC2MC) balancing method. An “adaptive selection mode based on the state of high energy battery” balancing strategy is proposed. The proposed balancing strategy allows the proposed balancing circuit to have multiple balancing modes, flexible balancing paths, and switching between different balancing processes in real time, significantly improving the balancing speed. The inherent LC resonant reset structure of the forward converter is employed to achieve MOSFET zero-voltage switching (ZVS). To optimize the balancing performance, the circuit model is built and the balancing parameters in the circuit are analyzed. An experiment with an eight-cell lithium-ion battery pack was performed to verify the balancing effect of the proposed circuit, and comparison with a typical balancing circuit was carried out. Experimental results show that the proposed balancing circuit has a faster balancing speed.
A Simple Biosensor Based on Streptavidin-HRP for the Detection of Bacteria Exploiting HRPs Molecular Surface Properties
Authors: Savini Filippo , Mutter Natalie , Baumgartner Katja , Barišić Ivan
Published: September 2023

Bacterial contamination of water and food sources is still a major source of diseases. Early detection of potential pathogens is key to prevent their spreading and severe health risks. Here, we describe a fast, low-cost detection assay based on horseradish peroxidase (HRP) conjugated to streptavidin for the direct identification of bacteria. Streptavidin can bind to bacterial cells due to its high affinity for biotin, a natural component of microbial cell surfaces. Upon binding to bacteria, the HRP converts a chromogenic substrate, resulting in a visible color change. In the present study, we evaluated different detection platforms regarding their compatibility with the detection principle. To reduce background signals and increase the sensitivity of HRP-based assays, the binding of HRP to surfaces and biomolecules was intensively investigated. The final assay successfully detected the most relevant bacterial strains in drinking water, such as Escherichia coli, Klebsiella pneumonia, and Enterobacter cloacae.
Self-Healing Coatings Consisting of an Outer Electrodeposited Epoxy Resin Layer and an Inner Porous Anodic Oxide Layer with Healing Agents for the Corrosion Protection of Al Alloys
Authors: Takada Rin , Hirasawa Kota , Takahashi Hideaki , Chiba Makoto
Published: September 2023

Recently, new surface treatments for the corrosion protection of Al alloys by forming self-healing layers have attracted the attention of many researchers. The authors of this paper have previously developed self-healing polyurethane coatings with micro-capsules containing healing agents and porous anodic oxide films filled with healing agents. In this study, self-healing coatings consisting of an outer electrodeposited epoxy resin layer and an inner porous anodic oxide layer with healing agents were developed for the corrosion protection of Al alloys. The corrosion protection abilities of the self-healing coating were shown in Cu2+/Cl− solutions after damaging with indenters and were affected by freezing treatments and the tip angles of the indenter.
The Use of Soy and Egg Phosphatidylcholines Modified with Caffeic Acid Enhances the Oxidative Stability of High-Fat (70%) Fish Oil-in-Water Emulsions
Authors: Yesiltas Betül , García-Moreno Pedro J. , Sørensen Ann-Dorit M. , Banerjee Chiranjib , Anankanbil Sampson , Guo Zheng , Ogilby Peter R. , Jacobsen Charlotte
Published: September 2023

This study investigated the effect of the combined use of sodium caseinate (CAS), commercial phosphatidylcholine (PC), and modified PCs on the physical and oxidative stability of 70% fish oil-in-water emulsions. Caffeic acid was covalently attached to both modified PCs (PCs originated from soy and eggs) in order to increase the antioxidant activity of PCs and investigate the advantage of bringing the antioxidant activity to the close proximity of the oil-water interface. Results showed that oxidative stability was improved when part of the PC was substituted with modified soy PC or egg PC. Emulsions containing a low concentration of modified PCs (10 wt.% of total PC) resulted in a prooxidative effect on the formation of hydroperoxides compared to emulsions with free caffeic acid. On the other hand, a decrease in the formation of volatile oxidation products was observed for emulsions containing higher levels of modified PCs (60 wt.% of total PC) compared to the emulsions with free caffeic acid added at its equivalent concentration. Increased concentrations of modified PCs provided better oxidative stability in high-fat emulsions, independent of the modified PC type. Moreover, when oxidation was initiated by producing singlet oxygen near a single oil droplet using a focused laser, fluorescence imaging showed that the oxidation did not propagate from one oil droplet to another oil droplet.
Analytical Hierarchical Process to Establish the Criteria for Choosing Explosives Suppliers in Small and Medium Mining Companies
Authors: Ramírez Olivares Edison , Castillo-Vergara Mauricio
Published: September 2023

Mining plays a pivotal role in economies worldwide, contributing to employment, infrastructure, and the supply of essential raw materials. Chile’s global mining powerhouse, particularly in copper production, exemplifies this industry’s economic significance. The supplier selection process in the mining industry, a complex and multifaceted task, is explored in detail, specifically focusing on explosives procurement, a critical component for mineral extraction. The paper underscores the importance of informed supplier selection decisions, especially for SMEs, which often need more resources and capabilities for efficient management. To address these challenges, the study proposes applying the Analytic Hierarchical Process (AHP), a multi-criteria decision-making methodology, to identify and prioritize the criteria and sub-criteria pertinent to choosing explosives suppliers. A case study in the Coquimbo Region, Chile, involving SMEs in the mining sector is the empirical foundation for this research. Our research highlights that the foremost criterion for SMEs in the Coquimbo Region’s mining sector is “relationship with the environment and communities”. This reflects the national context of mining community tensions and the rising environmental standards and social expectations, which can profoundly impact mining operations. “Quality of products and services” is the second most crucial criterion, underscoring SMEs’ drive to enhance productivity and efficiency. “Contractual compliance” follows closely, signifying the integration of SMEs into broader social and environmental sustainability efforts. Conversely, “innovation” ranks as the least relevant criterion, indicating that SMEs prioritize traditional processes due to limited resources and cost constraints. These insights are valuable for mining supplier company managers, emphasizing the need for sustainability, corporate social responsibility, and management control systems.
Relative Availability of Nitrogen and Calcium Regulates the Growth of Poplar Seedlings Due to Transcriptome Changes
Authors: Weng Xiaohang , Li Hui , Zhou Yongbin , Ren Chengshuai , Zhang Songzhu , Liu Liying
Published: September 2023

The concentrations of exogenous nitrogen and calcium can significantly regulate plant growth and photosynthesis and mutually affect their absorption and utilization. However, whether there is an optimal nitrogen–calcium ratio (N:Ca ratio) in poplar seedling growth and physiological adaptation and what the mechanism of changes in the transcriptome is remain unclear. In this study, three different N:Ca ratios were used to grow poplar seedlings, and physiological and transcriptomic methods were used to study the molecular mechanisms of poplar growth under nitrogen–calcium synergy and to determine the optimal N:Ca ratio for poplar seedling growth. The results of this study showed that maximum poplar seedling growth occurred in the treatment with an N:Ca ratio of 2, which resulted in significantly greater induction of growth than the two other treatments (p < 0.05). Under the lowest N:Ca ratio, poplar seedlings can ensure normal development by regulating photosynthesis, while under the highest N:Ca ratio, regulating nitrogen metabolism can achieve the same result. These results contribute to a better understanding of the molecular mechanisms by which poplar seedlings respond to different ratios of N:Ca. This study provides a valuable basis for exploring the synergistic effects of nitrogen and calcium on the growth of poplar shelterbelts.
Mapping Above-Ground Carbon Stocks at the Landscape Scale to Support a Carbon Compensation Mechanism: The Chocó Andino Case Study
Authors: Cuesta Francisco , Calderón-Loor Marco , Rosero Paulina , Miron Noam , Sharf Andrei , Proaño-Castro Carolina , Andrade Felipe
Published: September 2023

(1) Background: Tropical Mountain forests (TMF) constitute a threatened major carbon sink due to deforestation. Carbon compensation projects could significantly aid in preserving these ecosystems. Consequently, we need a better understanding of the above-ground carbon (AGC) spatial distribution in TMFs to provide project developers with accurate estimations of their mitigation potential; (2) Methods: integrating field measurements and remote sensing data into a random forest (RF) modelling framework, we present the first high-resolution estimates of AGC density (Mg C ha−1) over the western Ecuadorian Andes to inform an ongoing carbon compensation mechanism; (3) Results: In 2021, the total landscape carbon storage was 13.65 Tg in 194,795 ha. We found a broad regional partitioning of AGC density mediated primarily by elevation. We report RF-estimated AGC density errors of 15% (RMSE = 23.8 Mg C ha−1) on any 10 m pixel along 3000 m of elevation gradient covering a wide range of ecological conditions; (4) Conclusions: Our approach showed that AGC high-resolution maps displaying carbon stocks on a per-pixel level with high accuracy (85%) could be obtained with a minimum of 14 ground-truth plots enriched with AGC density data from published regional studies. Likewise, our maps increased precision and reduced uncertainty concerning current methodologies used by international standards in the Voluntary Carbon Market.
Effects of Weevil (Rhynchophorus palmarum), Teosinte (Dioon mejiae) and Caesar’s Mushroom (Amanita caesarea) on the Properties of Lactobacillus acidophilus LA-K
Authors: Aleman Ricardo S. , Avila Dany , Avila Allan , Marcia Jhunior , Picha David , Aryana Kayanush , Montero-Fernández Ismael
Published: September 2023

Weevil (Rhynchophorus palmarum) powder, teosinte (Dioon mejiae) and Caesar’s mushroom (Amanita caesarea) flour have bioactive compounds with significant nutritional applications. This paper aimed to examine the influence of weevil, teosinte, and mushroom powders on the protease activity, acid tolerance, bile tolerance, lysozyme tolerance, and gastric juice resistance ability of Lactobacillus acidophilus LA-K. Acid tolerance was determined by adjusting the pH of MRS broth to 2.0 for L. acidophilus incubated under aerobic conditions at 37 °C. Bile tolerance was determined by incorporating 0.3% of oxgall. Protease activity was determined spectrophotometrically at 340 nm. Resistance to 100 mg/L of lysozyme in an electrolyte solution was also determined. All ingredients were incorporated at 2% (w/v), while the control had no added ingredients. Acid and lysozyme tolerance were examined at 0, 30, 60, 90, and 120 min of incubation, whereas bile tolerance was analyzed at 0, 4, and 8 h. Gastric juice tolerance was determined at pH 2, 3, 4, 5, and 7 during 0 and 30 min of incubation, while protease activity was evaluated at 0, 12, and 24 h. Use of weevil flour, and Caesar’s mushroom powder resulted in significantly (p < 0.05) lower counts for bile tolerance, acid tolerance, lysozyme resistance and simulated gastric juice tolerance characteristics. Protease activity increased with the use of teosinte flour. As such, this probiotic bacterium can be used alongside certain novel food sources at 2% concentration in the manufacture of fermented products such as yogurt.
The Application of Nitrogen Curtain Technology to Longwall Goaf to Prevent the Spontaneous Combustion of Coal: A Case Study in Shajihai Coalmine, China
Authors: Geng Hai-Jiang , Zhao Ya-Ming , Liu Xiang-Lan , Tian Fu-Chao
Published: September 2023

To enhance the inerting effect of nitrogen on large longwall goaf, a novel goaf-inerting method of using a full cross-section nitrogen curtain for a U-shaped ventilation working face is developed. The working principle of the full cross-section nitrogen curtain is elucidated. The design principle and key parameters of the nitrogen curtain needed to achieve an optimum nitrogen injection effect are established. The nitrogen curtain technology is successfully applied to the scenario of fire prevention in the underground goaf. The field study shows that the full cross-section curtain injection of nitrogen exhibits many advantages such as simple operation and homogeneous diffusion. The implementation of the nitrogen curtain reduced the maximum width of the goaf oxidation zone from 70 m to 20 m. And the CO concentration in the upper corner decreased from 21.8 ppm to 11.2 ppm after 18 h of nitrogen injection. After 48 h of injection, the CO concentration in the upper corner remained unchanged and the concentration had reduced to 0 in the lower corner. It was demonstrated that the inerting efficiency of the full cross-section nitrogen curtain reached 86% in the upper corner and 100% in the lower, which is significantly superior to the traditional buried-pipe nitrogen injection method. The effect verifies the effectiveness of the curtain injection method of nitrogen, which can ensure a safe working face production.
Assessing the Relationship between Gastrointestinal and Pancreatic Neuroendocrine Tumor Grade and Overall Survival: A Systematic Review and Meta-Analysis
Authors: Malik Preeti , Patel Neel , Khayyat Azadeh , Asad Muhammad , Dawoodi Sameer , Chandramohan Sangeetha , Unachukwu Nkechi , Nasyrlaeva Bibimariyam , Vaisyambath Laseena , Chowdary Sriram B. , Venkata Vikramaditya Samala , Patel Urvish
Published: September 2023

Background: Neuroendocrine tumors (NET) are a rare group of epithelial neoplasms present in the gastrointestinal tract (GI) (67.5%) and bronchopulmonary tree (25.3–30%), and in 15% of cases, their primary sites cannot be identified. Although endoscopic screening, improvements in pathological techniques, and early detection have shown improvements in NET survival rates, the prognosis of advanced, metastatic, and poorly differentiated NET is very poor. In this study, we aimed to evaluate the effect of gastrointestinal and pancreatic (GEPs) NETs’ grade on overall survival. Method: We searched observational studies describing the overall survival or prognostic factors of primary GEP NETs from May 2011–May 2021 following the PRISMA guidelines. Studies describing the effect of primary grade 3 GEP NETs on overall survival were included. A meta-analysis was performed, and a pooled hazard ratio and their 95% confidence interval (95% CI) were obtained. Forest plots were created using random effects models and a sensitivity analysis was performed to account for the heterogeneity. Results: Seven studies with 7692 confirmed patients were included. In our meta-analysis, grade 3 GEP NETs were associated with higher odds of poor survival (pooled HR: 2.73; 95% CI: 1.36–5.47; p = 0.005), with a 92% heterogeneity between studies (p < 0.0001). To account for this heterogeneity, a sensitivity analysis was performed by removing two outlying studies (Fathi et al. and Foubert et al.) on funnel plots. The results after the sensitivity analysis did not change and still showed a significant association of grade 3 with a poor survival (pooled HR: 4.53; 95% CI: 3.54–5.78; p < 0.00001), with no heterogeneity between studies (p = 0.72; I2 = 0%). Conclusions: Our meta-analysis found that grade 3 GEP NETs are associated with poor survival and additional future studies are needed to identify other risk factors associated with poor survival in GEP NETs to improve their mortality.
“It Comes in Steps and Stages”: Experiences of People Living with HIV in Achieving Employment
Authors: Rajabiun Serena , Lightner Joseph S. , Sullivan Marena , Flaherty Jessica , Nguyen Chau , Ramirez-Forcier Joseph , Myers Janet J.
Published: September 2023

People living with HIV who are seeking jobs experience unique barriers to obtaining employment at the individual, group, and community levels. Traditional employment assistance programs can provide support but may not be tailored to some people living with HIV who often experience barriers to work related to their social needs (such as housing instability) or their lack of consistent engagement in the workforce. To understand how people living with HIV return to work, in-depth interviews were conducted with 43 participants enrolled in interventions coordinating HIV care with housing and employment services at eight sites across the US. Four themes emerged on strategies to increase employment: (1) assessing and responding to employment needs that align with their socio-economic environment; (2) using social networks among family and friends for referrals and support; (3) engaging with navigators who are able to connect clients to skills building opportunities and job resources; and (4) addressing the system barriers such as helping with unmet basic needs (e.g. transportation), finding employers who can accommodate workers with income limits associated with public benefits, and helping immigrants, transgender individuals, and people experiencing homelessness secure legal documentsthat facilitate entry into employment by reducing stigmatized identities.
3D Reconstruction of Fishes Using Coded Structured Light
Authors: Veinidis Christos , Arnaoutoglou Fotis , Syvridis Dimitrios
Published: September 2023

3D reconstruction of fishes provides the capability of extracting geometric measurements, which are valuable in the field of Aquaculture. In this paper, a novel method for 3D reconstruction of fishes using the Coded Structured Light technique is presented. In this framework, a binary image, called pattern, consisting of white geometric shapes, namely symbols, on a black background is projected onto the surface of a number of fishes, which belong to different species. A camera captures the resulting images, and the various symbols in these images are decoded to uniquely identify them on the pattern. For this purpose, a number of steps, such as the binarization of the images captured by the camera, symbol classification, and the correction of misclassifications, are realized. The proposed methodology for 3D reconstructions is adapted to the specific geometric and morphological characteristics of the considered fishes with fusiform body shape, something which is implemented for the first time. Using the centroids of the symbols as feature points, the symbol correspondences immediately result in point correspondences between the pattern and the images captured by the camera. These pairs of corresponding points are exploited for the final 3D reconstructions of the fishes. The extracted 3D reconstructions provide all the geometric information which is related to the real fishes. The experimentation demonstrates the high efficiency of the techniques adopted in each step of the proposed methodology. As a result, the final 3D reconstructions provide sufficiently accurate approximations of the real fishes.
Efficient Extraction of Deep Image Features Using a Convolutional Neural Network (CNN) for Detecting Ventricular Fibrillation and Tachycardia
Authors: Mjahad Azeddine , Saban Mohamed , Azarmdel Hossein , Rosado-Muñoz Alfredo
Published: September 2023

To safely select the proper therapy for ventricular fibrillation (VF), it is essential to distinguish it correctly from ventricular tachycardia (VT) and other rhythms. Provided that the required therapy is not the same, an erroneous detection might lead to serious injuries to the patient or even cause ventricular fibrillation (VF). The primary innovation of this study lies in employing a CNN to create new features. These features exhibit the capacity and precision to detect and classify cardiac arrhythmias, including VF and VT. The electrocardiographic (ECG) signals utilized for this assessment were sourced from the established MIT-BIH and AHA databases. The input data to be classified are time–frequency (tf) representation images, specifically, Pseudo Wigner–Ville (PWV). Previous to Pseudo Wigner–Ville (PWV) calculation, preprocessing for denoising, signal alignment, and segmentation is necessary. In order to check the validity of the method independently of the classifier, four different CNNs are used: InceptionV3, MobilNet, VGGNet and AlexNet. The classification results reveal the following values: for VF detection, there is a sensitivity (Sens) of 98.16%, a specificity (Spe) of 99.07%, and an accuracy (Acc) of 98.91%; for ventricular tachycardia (VT), the sensitivity is 90.45%, the specificity is 99.73%, and the accuracy is 99.09%; for normal sinus rhythms, sensitivity stands at 99.34%, specificity is 98.35%, and accuracy is 98.89%; finally, for other rhythms, the sensitivity is 96.98%, the specificity is 99.68%, and the accuracy is 99.11%. Furthermore, distinguishing between shockable (VF/VT) and non-shockable rhythms yielded a sensitivity of 99.23%, a specificity of 99.74%, and an accuracy of 99.61%. The results show that using tf representations as a form of image, combined in this case with a CNN classifier, raises the classification performance above the results in previous works. Considering that these results were achieved without the preselection of ECG episodes, it can be concluded that these features may be successfully introduced in Automated External Defibrillation (AED) and Implantable Cardioverter Defibrillation (ICD) therapies, also opening the door to their use in other ECG rhythm detection applications.
Limitations of Out-of-Distribution Detection in 3D Medical Image Segmentation
Authors: Vasiliuk Anton , Frolova Daria , Belyaev Mikhail , Shirokikh Boris
Published: September 2023

Deep learning models perform unreliably when the data come from a distribution different from the training one. In critical applications such as medical imaging, out-of-distribution (OOD) detection methods help to identify such data samples, preventing erroneous predictions. In this paper, we further investigate OOD detection effectiveness when applied to 3D medical image segmentation. We designed several OOD challenges representing clinically occurring cases and found that none of the methods achieved acceptable performance. Methods not dedicated to segmentation severely failed to perform in the designed setups; the best mean false-positive rate at a 95% true-positive rate (FPR) was 0.59. Segmentation-dedicated methods still achieved suboptimal performance, with the best mean FPR being 0.31 (lower is better). To indicate this suboptimality, we developed a simple method called Intensity Histogram Features (IHF), which performed comparably or better in the same challenges, with a mean FPR of 0.25. Our findings highlight the limitations of the existing OOD detection methods with 3D medical images and present a promising avenue for improving them. To facilitate research in this area, we release the designed challenges as a publicly available benchmark and formulate practical criteria to test the generalization of OOD detection beyond the suggested benchmark. We also propose IHF as a solid baseline to contest emerging methods.
PdStuA Is a Key Transcription Factor Controlling Sporulation, Hydrophobicity, and Stress Tolerance in Penicillium digitatum
Authors: Du Yujie , Zhu Jinfan , Tian Zhonghuan , Long Chaoan
Published: September 2023

Penicillium digitatum has become one of the main pathogens in citrus due to its high spore production and easy spread. In this study, the function of the APSES transcription factor StuA in P. digitatum was characterized, and the results indicated that it was involved in conidium and conidiophore development. No conidiophores were observed in the mycelium of the ∆PdStuA mutant that had grown for two days, while an abnormal conidiophore was found after another two days of incubation, and only small thin phialides as well as a very small number of spores were formed at the top of the hyphae. Moreover, it was observed that the ∆PdStuA mutant showed various defects, such as reduced hydrophobicity and decreased tolerance to cell wall inhibitors and H2O2. Compared to the original P. digitatum, the colony diameter of the ∆PdStuA mutant was not significantly affected, but the growth of aerial hyphae was obviously induced. In in vivo experiments, the spore production of the ∆PdStuA mutant grown on citrus fruit was remarkably decreased; however, there was no significant difference in the lesion diameter between the mutant and original strain. It could be inferred that less spore production might result in reduced spread in citrus, thereby reducing the green mold infection in citrus fruit during storage. This study provided a gene, PdStuA, which played key role in the sporulation of P. digitatum, and the results might provide a reference for the molecular mechanisms of sporulation in P. digitatum.
Modulatory Effect of Beneficial Enterococci and Their Enterocins on the Blood Phagocytes in Murine Experimental Trichinellosis
Authors: Vargová Miroslava , Revajová Viera , Lauková Andrea , Hurníková Zuzana , Dvorožňáková Emília
Published: September 2023

Bacteriocins (enterocins) represent a new therapeutic strategy in various intestinal and non-intestinal infections. In antiparasitic defence, an oxidative inflammation of phagocytes is effective in destroying new-born Trichinella spiralis larvae. The strains Enterococcus faecium CCM8558 and E. durans ED26E/7 and their enterocins, enterocin M and a durancin-like enterocin, respectively, were administered daily, and mice were then infected with T. spiralis larvae on the seventh day of treatment. Phagotest and Bursttest kits were used to detect the phagocytosis and respiratory burst in blood leukocytes. T. spiralis infection inhibited phagocytosis from day 11 post-infection (dpi) during the migration of new-born larvae into the muscles. E. faecium CCM8558, E. durans ED26E/7, and the durancin-like enterocin increased phagocytic activity from day 11 dpi. Both strains and their enterocins (enterocin M and durancin-like) stimulated the ingestion capability of phagocytes from 18 to 32 dpi. Enterococci/enterocins therapy prevented a reduction in cells with respiratory burst caused by T. spiralis infection from 11 dpi. The enzymatic activity of phagocytes was stimulated on 18 and 25 dpi, particularly by E. faecium CCM8558 and enterocin M. Enterocin M and the durancin-like enterocin were as effective in stimulating phagocytosis as the bacterial strains that produce them. The stimulation of phagocytosis could contribute to decreased larval migration and reduced parasite burden in the host.
Regulatory T Cells in Atherosclerosis: Is Adoptive Cell Therapy Possible?
Authors: Churov Alexey V. , Chegodaev Yegor S. , Khotina Victoria A. , Ofitserov Vladimir P. , Orekhov Alexander N.
Published: September 2023

Atherosclerosis is an insidious vascular disease with an asymptomatic debut and development over decades. The aetiology and pathogenesis of atherosclerosis are not completely clear. However, chronic inflammation and autoimmune reactions play a significant role in the natural course of atherosclerosis. The pathogenesis of atherosclerosis involves damage to the intima, immune cell recruitment and infiltration of cells such as monocytes/macrophages, neutrophils, and lymphocytes into the inner layer of vessel walls, and the accumulation of lipids, leading to vascular inflammation. The recruited immune cells mainly have a pro-atherogenic effect, whereas CD4+ regulatory T (Treg) cells are another heterogeneous group of cells with opposite functions that suppress the pathogenic immune responses. Present in low numbers in atherosclerotic plaques, Tregs serve a protective role, maintaining immune homeostasis and tolerance by suppressing pro-inflammatory immune cell subsets. Compelling experimental data suggest that various Treg cell-based approaches may be important in the treatment of atherosclerosis. Here we highlight the most recent advances in our understanding of the roles of FOXP3-expressing CD4+ Treg cells in the atherogenic process and discuss potential translational strategies for the treatment of atherosclerosis by Treg manipulation.
Serving the Dead as Serving the Living: Examining the Concept of Burial and Life Consciousness in Medieval China
Authors: Wang Wei
Published: September 2023

In the minds of ancient people, tombs and burials were where the lives of this world ended and another type of life began. By incorporating the concepts of life found in Confucianism, Taoism, Buddhism, and the widespread belief in ghosts and immortals, burial ceremonies evolved during the Wei and Jin 魏晋 dynasties (220–420) into an integrated and unified notion of burial. The funeral ritual’s imaginative and fanciful depictions of the hereafter express sentimental devotion to life and contemplation of death. The burial ceremony and tomb architecture change in accordance with how the concepts of sacrifice and ghosts develop. The features of people’s belief in ghosts and immortality are reflected in particular burial practices. The popularity of necromancy burials and ghost marriages during the Middle Ages (third to sixth centuries) bring to light the binary antagonism between the soul and the body in burial, as well as the emphasis on spiritual freedom and physical immortality in the life philosophy.
Long-Term Aging Study on the Solid State Interfacial Reactions of In on Cu Substrate
Authors: Hung Han-Tang , Chang Fu-Ling , Tsai Chin-Hao , Liao Chia-Yi , Kao C. R.
Published: September 2023

Indium is considered a candidate low-temperature solder because of its low melting temperature and excellent mechanical properties. However, the solid-state microstructure evolution of In with different substrates has rarely been studied due to the softness of In. To overcome this difficulty, cryogenic broad Ar+ beam ion polishing was used to produce an artifact-free Cu/In interface for observation. In this study, we accomplished phase identification and microstructure investigation at the Cu/In interface after long-term thermal aging. CuIn2 was observed to grow at the Cu/In interface and proved to be a stable phase in the Cu–In binary system. The peritectoid temperature of the Cu11In9 + In → CuIn2 reaction was confirmed to be between 100 and 120 °C. In addition, the growth rate of CuIn2 was discovered to be dominated by the curvature of the reactant Cu11In9/In phase and the temperature difference with the peritectoid temperature. Finally, a comprehensive microstructural evolution mechanism of the Cu/In solid-state interfacial reaction was proposed.