bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Nilai Tambah Produksi pada Industri Tempe Di Kecamatan Barabai Kabupaten Hulu Sungai Tengah
Authors: Saihani Azwar
Published: December 2019

This research has two objectives, namely to determine soybean industry overview in sub Barabai and calculating the amount of value added generated by the soybean industry in the Barabai District Hulu Sungai Tengah Regency.   The research was conducted at tempe existing tempe industrial business in the District Barabai Hulu Sungai Tengah Regency. The method used in analyzing the data available from industry employers in the Barabai District Hulu Sungai Tengah is to use the formula of gross value added, net value added, and value-added raw materials. The calculations associated with the equipment used, the main raw material, and auxiliary raw materials used in the process of making tempe.   Based on the results of research conducted on the existing soybean industry in the District Barabai gross value added generated from all respondents of Rp 56.247.500, net value added generated amounted to Rp 48.062.500, while for value-added raw materials amounting to Rp 125.363/Kg. The existence of the soybean industry in Barabai be able to increase the added value for entrepreneurs tempe
Analisis Kelayakan Investasi Perkebunan Rambutan di Desa Jungkal Kecamatan Lampihong Kabupaten Balangan
Authors: Sitanggang Miranda Romaully Br. , Norhalimah Norhalimah
Published: December 2019

This study aims to determine the feasibility of rambutan plantation investment in Jungkal Village, Lampihong Subdistrict, Balangan Regency, seen from non-financial aspects, namely market aspects, technical aspects, management aspects, and financial aspects. The study was conducted in Jungkal Village, Lampihong District. The research method used was the census method where as many as 20 rambutan garden business owners were made respondents. Data collection was conducted from May - August 2014. Analysis of financial aspects used investment criteria consisting of Net Present Value (NPV), Internal Rate of Return (IRR), Net Benefit Cost Ratio (Net B / C), and payback period. The results of research obtained from non-financial aspects show that the investment in rambutan plantation is feasible, it is shown that the market potential is quite high, the location of the plantation business that supports the success of the business, and the work plan in its management can be done by taking into account existing conditions. From the financial aspects of the rambutan plantation business investment in Jungkal Village, it is feasible to show the Net Present Vlue (NPV) of Rp134,646,379, - the value of the Internal Rate of Return (IRR) is greater than the discount rate of 30.01%. Net B / C is 4.50, and the payback period is 8 years 11 months 26 days, this shows that financially the investment in rambutan plantation is feasible.
Pengaruh Pemberian Pupuk Cair Urine Sapi terhadap Pertumbuhan dan Hasil Tanaman Mentimun (Cucumis sativus L.) pada Lahan Podsolik Merah Kuning
Authors: Hafizah Nur , Rusmadi Rusmadi
Published: December 2019

Yellow red podsolic soil has the potential for crop cultivation. The problems faced in the development of plant cultivation on yellow red podsolic land are very low pH and nutrient poor. The purpose of this study was (i) to know the effect of giving cow urine liquid fertilizer to the growth and yield of cucumber plants on yellow red podsolic land (ii) to obtain the best dose of cow urine liquid fertilizer on the growth and yield of cucumber plants on red yellow podzolic fields. The study was conducted in Mantimin Village, Batu Mandi Subdistrict, Balangan Regency in June - July 2011. This study used a Randomized Block Design (RBD), with 5 treatments and 4 replications, so that all of them were 20 experimental units. Each experimental unit consists of 4 plants. Factors are tested for cow urine liquid dosage, u0 = 0 cc / liter of water / plot, u1 = 25 cc of water per plot, u2 = 50 cc / liter of water / plot, u3 = 75 cc / liter of water / plot, and u4 = 100 cc / liter of water / plot. The results showed that the treatment of doses of cow urine fertilizer significantly affected plant height variables aged 14 days after planting (HST), number of leaves aged 14 HST, number of branches, age of plants at flowering, number of fruit crops and weight of fruit at the best dose is 100 cc / liter of water / plot (u4) and does not show any influence on plant height at 28 HST.
Analisis Komparatif Pendapatan Petani Pelaksana Pengelolaan Tanaman Terpadu Padi Sawah dengan Petani Non Pelaksana Pengelolaan Tanaman Terpadu Padi Sawah di Desa Pugaan Kecamatan Pugaan Kabupaten Tabalong
Authors: Saihani Azwar , As’ari As’ari
Published: December 2019

This is research result with aim to for the cost analysis of, acceptance and comparison of earnings of farmer of executor of manajement of inwrought crop (PTT) by execute management of inwrought crop of rice field paddy. This research is executed by in Countryside of Pugaan Sub-Province of Tabalong. Election of farmer of sampel by purposive counted 23 people for the farmer of executor of PTT rice field paddy and by random sampling counted 23 people for farmer oflis non executor of PTT rice field paddy. Data which used in this research in the form of primary data and data of sekunder collected with interview technique, and record-keeping of survey. Management of inwrought crop ( Paddy rice field PTT ) are new innovation to solve various problem of improvement of paddy crop productivity. Result of analysis of that flattening to flatten in one hectare is expense of for the executor of PTT Rp. 20.046.618,45 and to the non executor of PTT Rp. 16.641.386,9, while result produce Rp. 22. 638.000 and Rp. 17.801.640,85. Earnings for the farmer of executor of PTT is Rp. 17.232.171,05 in one hectare, for farmer of non executor of PTT is Rp. 12.755.601,16 in one hectare. Of the analysis result concluded that flattening to flatten in one hectare of expense of, acceptance and earnings of farmer of executor of higher PTT than farmer of non executor of PTT
Demostración de afecto materno y paterno: la experiencia de adolescentes
Authors: Lozano Razo Georgina , Zavala Rayas Javier , Miramontes Zapata Silvia del Carmen , Sánchez Bautista Juan Martín , Jiménez López María Dolores , Pacheco Medina Francisco , García Sánchez María Dolores , Luis Delgado Oliva Erendira
Published: December 2019

El objetivo de la presente investigación fue describir la experiencia de hombres y mujeres adolescentes de 15 a 18 años, que habitan en el estado de Zacatecas, respecto a la demostración de afecto paterno y materno. Para ello se realizó un muestreo por cuotas, por nivel escolar de secundaria y bachillerato y género; se obtuvo una muestra total de 80 adolescentes, a los cuales se les pidió que contestaran dos preguntas: ¿Qué hace tu mamá para demostrarte afecto? y ¿qué hace tu papá para demostrarte afecto? Las respuestas fueron sometidas a un análisis de contenido. Se encontró que para los varones, las categorías más comunes de afecto materno, fueron: expresión física de afecto, expresión verbal de afecto, cuidados y protección y expresión material de afecto. Mientras que para el afecto paterno fueron: expresión material de afecto, pasar tiempo con ellos y expresión física de afecto. Por su parte, para las adolescentes, las categorías más comunes de afecto materno, fueron: expresión física de afecto, expresión verbal de afecto y cuidados y protección. Mientras que las de afecto paterno, fueron: expresión física de afecto, expresión verbal de afecto y no demuestra su afecto.
Prácticas de crianza y desarrollo afectivo y emocional de los niños
Authors: Frías Armenta Martha , Fraijo Sing Blanca , Tapia Fonllem César
Published: December 2019

La familia es el lugar donde los niños gozan de sus primeras interacciones con el mundo, los padres les proporcionan el soporte emocional y social, además de las actividades de aprendizaje. Las madres, especialmente, invierten grandes cantidades de recursos, tiempo y energía para que puedan sobrevivir y convertirse en adultos exitosos. Teóricamente, las madres y los padres buscan invertir en la crianza de sus hijos, para que éstos logren un proceso de adaptación y sobrevivencia al ambiente que les tocó vivir, por lo tanto, buscan las mejores técnicas para lograrlo. En este sentido, el presente estudio investiga cómo los padres y las madres se perciben a sí mismos en sus prácticas de crianza y en las formas de mostrar afecto a sus hijos e hijas. La muestra la conformaron 201 padres y madres de familia escogidos al azar en la ciudad de Hermosillo, Sonora. Las entrevistas se llevaron a cabo en sus hogares por psicólogas. Estadísticas descriptivas, t de student y chi cuadrada fueron utilizadas para el análisis de datos. Los resultados nos indican que los padres se aprecian a sí mismos como buenos, responsables y amorosos y no utilizaron el castigo físico. Se puede concluir que ellos tienen una percepción positiva de sus prácticas de crianza y de cómo educan a sus hijos.
Satisfacción en el noviazgo en adultos jóvenes según su orientación sexual en Mérida, Yucatán
Authors: Cahuich Lemus Génesis , Chacón Alvarado Jessica , Juárez Mendoza Mayra , Kantún López Leidy , Vázquez González Luz
Published: December 2019

Las relaciones heterosexuales han sido más aceptadas que las relaciones de diferente orientación sexual, sin embargo, no se puede ignorar la existencia de estas últimas en una relación de noviazgo. La presente investigación busca establecer si existe relación entre la satisfacción en el noviazgo, dependiendo de la orientación sexual y el género, en un grupo de adultos jóvenes. Se utilizó la Escala Multidimensional de Satisfacción en el Noviazgo de Bargas y García (2011), compuesta por 11 dimensiones. La muestra estuvo constituida por 90 participantes de 18 a 30 años de los cuales fueron 44 hombres y 46 mujeres. En cuanto a la orientación sexual, 47 dijeron ser heterosexuales, y 43 con una orientación sexual diferente. Los resultados según la orientación sexual y la satisfacción en el noviazgo sugieren que las personas con orientación heterosexual son los más satisfechos en las dimensiones de interacción familiar que los de otra orientación sexual. Respecto a la satisfacción en hombres y mujeres independientemente de su orientación sexual, los resultados sugieren que los hombres están más satisfechos que las mujeres en lo que se refiere a pasar tiempo juntos y compartir actividades, y las mujeres están más satisfechas respecto de la interacción con los amigos de su pareja, en la toma de decisiones, acuerdos y la comunicación con la pareja. Se discute sobre la influencia de las relaciones familiares en el noviazgo debido a que si no existe la aceptación el distanciamiento familiar puede afectar la satisfacción en la pareja.
Validación en México de la Escala de Autoverbalizaciones al Hablar en Público
Authors: Moral de la Rubia José , Antona Casas César Jesús , García Cadena Cirilo Humberto
Published: December 2019

La escala de Autoverbalizaciones al Hablar en Público (SSPS; Hofmann & DiBartolo, 2000), es un instrumento para evaluar cogniciones en la situación de hablar en público, la cual comúnmente genera algún grado de ansiedad. La escala presentó buenas propiedades psicométricas en su estudio original con muestras estadounidenses al igual que en estudios de validación con muestras españolas. A pesar de su importancia, no estaba adaptada en población mexicana, así los objetivos de este estudio fueron: traducir la escala SSPS al español de uso en México, validar su estructura de dos factores correlacionados, calcular su consistencia interna, describir su distribución, contrastar diferencias entre sexos y observar la relación de la SSPS con deseabilidad social, que es un constructo potencialmente vinculado a la ansiedad social. La escala SSPS y el Inventario Balanceado de Deseabilidad Social al Responder (BIDR; Paulhus, 1998), fueron aplicados a una muestra probabilística estratificada por sexos de estudiantes universitarios. La estructura de dos factores correlacionados de autoverbalizaciones negativas y positivas mostró un ajuste adecuado a los datos e invarianza entre ambos sexos por mínimos cuadrados generalizados. La consistencia interna fue alta. La distribución fue asimétrica positiva. La correlación con deseabilidad social fue significativa sobre todo con el factor de autoengaño. Los varones obtuvieron medias más elevadas, pero hubo equivalencia estadística entre las medias de ambos sexos al controlar la deseabilidad social. Se sugiere el uso de la escala SSPS en México, controlando el sesgo de la deseabilidad social.
Significado psicológico de los constructos novios, amigovios y free para jóvenes Pachuqueños
Authors: García Meraz Melissa , Vizzuetth Herrera Aleyda , Guzmán Saldaña Rebeca María Elena
Published: December 2019

Con el objetivo de conocer el significado psicológico de los constructos novios, amigovios y free, en la presente investigación se trabajó con base en el uso de la técnica de redes semánticas naturales (Figueroa, González, & Solís, 1981); pero se utilizó el procedimiento y nomenclatura propuestos por Reyes-Lagunes (1993). Los estímulos se aplicaron a un total de 230 participantes, de los cuales 32 han mantenido una relación de amigovios, 29 han tenido una relación free, 74 tienen un noviazgo y 95 personas manifestaron no tener ninguna relación. El instrumento fue aplicado de manera individual y colectiva en diferentes escuelas del municipio de Pachuca, Hidalgo, garantizando el anonimato. Los resultados reflejan que el estímulo amigovios está definido por palabras como amistad, cariño, diversión, comprensión y confianza. El estímulo free está definido por aspectos como libertad, sexo, amistad, diversión y “no”. Mientras que el estímulo novios está definido por palabras como amor, cariño, honestidad, respeto, comprensión y amistad. Según Miller, Vandome y McBrewster (2010), las relaciones casuales son diferentes del sexo casual. En las relaciones que son descritas como sexo casual, no existe un interés emocional por la persona, no son amigos ni se tienen cariño o amor. El sexo casual es de una sola noche (one night stand). En cambio, los amigovios sí generan y esperan de su relación cariño y amor; se carece de la parte del compromiso, pero no de la intimidad: amor y cariño conviven con la informalidad. Por ello, los resultados son discutidos en términos de los cambios culturales y sociales que han atravesado el inicio y la disolución de las relaciones de pareja.
Simbolismo y Modernismo
Authors: Beltrán Almería Luis
Published: December 2019

El artículo cuestiona la dicotomía realismo/modernidad. Los estudios literarios occidentales del siglo pasado trataron de entender las diferencias estéticas entre el siglo XIX y el XX basándose principalmente en un concepto de mimesis. Estos intentos por explicar dichas diferencias están basados en una serie de reacciones ante los eventos artísticos mayores de la época; sin embargo, estas reacciones fueron de muy poco alcance como para definir a posteriori unas diferencias múltiples y proteiformes. Por lo anterior, el autor sugiere una concepción más amplia tomando en cuenta factores de mayor significación. De esta manera, el simbolismo, catalogado por la crítica como una moda creativa del último tercio del siglo XIX y asociado por algunos críticos al romanticismo y por otros a manifestaciones artísticas del siglo XX, es en realidad un fenómeno que se percibe desde Rabelais hasta Soldados de Salamina. El simbolismo se caracterizacomo una estética marcada por el hermetismo y la comicidad; una vuelta a la oralidad aunque distinta de la primitiva.
Ficción y memoria: narrador y estrategias discursivas en la literatura hispanoamericana contemporánea
Authors: González Sawczuk Susana Inés
Published: December 2019

Interesa la relación vincular de la ficción con la memoria que se manifiesta de acuerdo a las nuevas perspectivas de significación de lo real. Memoria que se construye por medio de estrategias discursivas que definen diferentes posicionamientos del narrador. Tres obras y tres escritores, en contextos diferentes, llevan adelante la exploración de los modos de narrar. Rodolfo Walsh (Argentina) deja estampada la memoria de una matanza en Operación masacre (1957), texto que combina la investigación y el periodismo y que se transforma en modelo de la ficción testimonial. En tiempos más cercanos, Elena Poniatowska (México) con estrategias diferentes recupera otro de los relatos del horror a partir de retazos de fragmentos, de breves crónicas de testigos, en La noche de Tlatelolco (1971). Por último, en 1980, se publica Respiración artificial (Ricardo Piglia). El personaje, Emilio Renzi, marca una narrativa de historias y significantes para leer otra dinámica política y cultural castigada por el terror y el exilio que trajo la última dictadura argentina de 1976.
Mentir y crear. Aproximaciones a Felisberto Hernández y Juan Carlos Onetti
Authors: Téllez Vargas Jorge
Published: December 2019

La relación entre la mentira y la ficción es un motivo arraigado en la literatura hispanoamericana del siglo XX. En el caso de Felisberto Hernández y Juan Carlos Onetti cobra una importancia fundamental en la medida en que nos remite a un segundo plano diegético de varios de sus textos. En los cuentos que analizo,“La envenenada” (1931) de Felisberto Hernández y “Un sueño realizado” (1941) de Juan Carlos Onetti, la relación verdad/mentira se expresa por medio de imágenes dramáticas puestas en escena que bien podrían entenderse como la poética misma de los textos. En ambos escritores, el desdoblamiento diegético puede verse como el ejercicio de un derecho imprescindible de todo narrador: la creación paralela de mundos que van en busca de la libertad artística. El interés primordial de este artículo se enfoca en el estudio y análisis de los mecanismos que permiten tales desdoblamientos y en la relación que, de esamanera, se establece entre las poéticas de ambos escritores.
Fortino Corral Rodríguez, editor. Ruta Crítica. Estudios sobre Literatura Hispanoamericana. Universidad de Sonora, 2007.
Authors: Moreno Fierro Glenda Liliana
Published: December 2019

Ruta Crítica. Estudios sobre Literatura Hispanoamericana es una colección de ensayos orientados hacia el análisis y la reflexión sobre el fenómeno literario, enparticular el hispanoamericano. Encontramos aquí reflexiones emitidas desde diversos puntos de vista, desde distintas dimensiones que conforman una muestra clara de qué es Hispanoamérica: un mosaico policromático de visiones. El libro está integrado por tres secciones: “Literatura mexicana”, “Ámbito hispanoamericano” y “Reflexión teórica: narrativa”.
Pro Rent-Gap-Theorie, contra habitualisierten Antikulturalismus
Authors: Ege Moritz
Published: December 2019

Kommentar zu Neil Smiths Rent-Gap-Aufsatz
Die Bodenwertsteuer als unterstützendes Instrument der Stadtplanung
Authors: Mühlleitner Daniel
Published: December 2019

Unser heutiges Bodenrecht verschafft den Grundstückseigentümern Einkommen und Vermögenswerte, die ihnen maßgeblich aufgrund der guten Lage, Infrastrukturausstattung oder Beschaffenheit des Grundstücks zufallen und für deren Höhe üblicherweise gesellschaftliche Leistungen verantwortlich sind. Aus dieser Situation erwächst eine Reihe stadtplanerischer Probleme, die beispielhaft erörtert werden und neben der Beeinflussung der Planung auch allokative Aspekte berühren. Als ein pragmatisches Mittel zur Unterstützung einer nachhaltigen Planung wird die Bodenwertsteuer diskutiert, die den unbebauten Boden ebenso stark wie den bebauten belastet und so einen Druck auf den Eigentümer ausübt, das Grundstück entsprechend der vorgesehenen Planung zu nutzen und die außerdem einen finanziellen Beitrag der von Entwicklungsmaßnahmen profitierenden Eigentümer einfordert.
Theorien der Stadt
Authors: Wehrheim Jan
Published: December 2019

Der hier besprochene Band richtet sich an alle an Stadt interessierten und damit auch gleichermaßen an Lernende wie Lehrende. An Erstere, weil das Buch in unterschiedliche theoretische Positionen und das Werk damit verknüpfter Autor*innen einführt. An Letztere richtet es sich, weil es sich durchaus zur Vorbereitung der Lehre eignet und dafür, einführende Texte für Studierende bereitzustellen, aber natürlich auch, weil auch die Lehrenden meist nicht alle Zugänge zur Stadtsoziologie detailliert kennen oder einzelne gern einmal auffrischen. Insgesamt überzeugt das Buch; die kleinen Schwächen erscheinen geradezu dem Gegenstand immanent zu sein, und es zeigt, wie intensiv sich die drei Autor*innen mit den Werken (und der dazugehörigen Sekundärliteratur) auseinandergesetzt haben. Vieles davon wurde, so ist der Danksagung zu entnehmen, bereits in der Lehre erprobt – vermutlich mit Erfolg.
EXPERIMENTAL AND MATHEMATICAL MODELING OF THE IRON OXIDE NANOPARTICLE PULMONARY RETENTION AT LONG-TERM LOW-LEVEL INHALATION EXPOSURE
Authors: Sutunkova M. P. , Katsnelson B. A. , Privalova L. I. , Gurvich V. B. , Konysheva L. K. , Shur V. Ya. , Shishkina E. V. , Minigalieva I. A. , Solovyeva S. N. , Zubarev I. V.
Published: December 2019

Airborne Fe2O3 nanoparticles (NPs) with the mean diameter of 14±4 nm produced at spark ablation from 99.99% pure iron rods were fed into a «nose-only» exposure tower for rats exposed for 4 h a day, 5 days a week during 3, 6 or 10 months at a mean concentration of 1.14±0.01 mg/m3. Nanoparticles filtered out of the air exhausted from the exposure tower proved insoluble in de-ionized water but gradually dissolved in the cell free fluid supernatant produced by broncho-alveolar lavage and in the sterile bovine blood serum. The Fe2O3 content in lungs was measured by the Electron Paramagnetic Resonance (EPR) spectroscopy. NP retention in lungs and in brain was visualized with the Transmission Electron Microscopy (TEM). It was found a relatively low but significant pulmonary accumulation of Fe2O3, gradually increasing with time but tending to attain an equilibrium level. Besides, TEM-images showed nanoparticles retention within alveolocytes and the myelin sheaths of brain fibers associated with their ultrastructural damage. A multi compartment system model was developed and identified which describes toxicokinetics of inhaled nanoparticles after their deposition in the lower airways as a process controlled by their (a) high ability to penetrate through the alveolar membrane; (b) active endocytosis; (c) in vivo dissolution. However, in this particular study, dissolution-depending mechanisms proved to be dominant due to the rather high solubility of the finest Fe2O3-NPs in biological milieux.
THE EFFECT OF SUBACUTE INTOXICATION WITH ETHYLENE CHLOROHYDRIN ON IMMUNE RESPONSES, TH1 AND TH2 LYMPHOCYTE FUNCTION AND CYTOKINE LEVELS IN RATS BLOOD
Authors: Zabrodskii P. F. , Maslyakov V. V. , Gromov M. S.
Published: December 2019

In experiments on outbred albino rats, it was established that subacute intoxication with ethylene chlorohydrin (0.2 LD50 daily for 4 days) causes a decrease in Th1 and Th2 lymphocytes function to the same extent, diminishes parameters of humoral and cellular immune responses and the content of immunoregulatory cytokines IFN- , IL-2, IL-4 in blood, increases concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.
STUDY OF THE NEW FERTILIZER TOXICITY
Authors: Istomin A. V. , Rumyantseva L. A. , Vetrova O. V. , Mikhailov I. G.
Published: December 2019

The article is devoted to the study of toxic effect of a new complex liquid mineral fertilizer «Agromineral» on the organism of laboratory animals. Results of sanitary and toxicological studies on assessment of toxicity and hazard of the agrochemical were analyzed ; based on investigation results, parameters of acute and subacute toxicity are established; irritating effects on skin and mucous membranes, cumulative effect, sensitizing effect were studied.
INFLUENCE OF INOSINE GLYCYL-CYSTEINYL-GLUTAMATE DISODIUM ON THE CLINICAL COURSE AND OUTCOME OF THE EXPERIMENTAL ALCOHOL-INDUCED LIVER CIRRHOSIS
Authors: Antushevich A. E. , Grebenyuk A. N. , Halyutin D. A. , Yarseva A. A.
Published: December 2019

An evaluation of the inosine glycil-cysteinyl-glutamate disodium efficacy as a means for therapy of toxic alcoholinduced liver cirrhosis was performed in experiments on outbred white rats. Experimental modeling of liver cirrhosis was carried out by administrating intragastrically to rats two hepatotoxicants– 40% ethanol at a dose of 3 g/kg, every other day for three weeks and 1% dimethylnitrosamine at a dose of 5 mg/kg, intraperitoneally the first 4 days per week. Inosine glycyl-cysteinyl-glutamate disodium was administered subcutaneously at a dose of 30 mg/kg daily for three weeks; application of the drug was started after the administration of hepatotoxicants was ended and clinical and morphological indicators of toxic liver cirrhosis were proved. Evaluation of the efficiency of inosine glycyl-cysteinyl-glutamate disodium as a therapeutic means for alcohol-induced liver cirrhosis was performed by morphological, histological and biochemical methods. It was found out that a combined action of ethanol and dimethylnitrosamine led to the development of toxic liver cirrhosis, which manifested by an increase in the rats body weight , characteristic morphological and histological changes in liver tissues, increased activity of alanine and aspartate aminotransferase, gamma-glutamyltranspeptidase, alkaline phosphatase and total bilirubin level, and an increase in the blood plasma of concentration of interleukin-1β, interferon-γ and tumor necrosis factor-α. A course administration of inosine glycyl-cysteinyl-glutamate disodium contributed to a decrease in the volume of connective tissue in the liver of animals, decrease in the activity of hepatic enzymes, decrease in the level of total bilirubin and the concentration of pro-inflammatory cytokines in the blood plasma. Data obtained show the efficacy of inosine glycyl-cysteinyl-glutamate disodium as a means for treating alcohol-induced liver cirrhosis.
CORRELATION OF P21 EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA WITH CLINICOPATHOLOGIC AND PROGNOSTIC PARAMETERS
Authors: Sadaf Safana , Loya Asif , Mushtaq Sajid , Akhter Noreen , Hussain Raza , Jamshed Arif
Published: December 2019

Purpose: Head and neck tumours include tumours of nose, paranasal sinuses, oropharynx, larynx and mouth. Squamous cell carcinoma (SCC) is the most common head and neck malignant tumour which accounts for 90% of head and neck malignant tumours. p21 is an important immunohistochemical marker which has signi cant role in predicting prognosis of head and neck SCC (HNSCC). Increased p21 expression in HNSCC is associated with bad prognosis in terms of increased risk of nodal metastasis, increased rate of recurrence and decreased survival rate. The purpose of this study was to evaluate the expression of p21 in HNSCC with various clinicopathologic and prognostic parametres. Materials and Methods: A total of 110 patients (n = 110) of HNSCC (oral cavity n = 98 and laryngeal tumours n = 12) were included in the study which were diagnosed and treated between January 2008 and January 2011 at a tertiary care centre in Pakistan. Mean age was 51 years (age range 15–78). 65 (59%) were male and 45 (41%) were female. Tumours were classi ed as p21 positive when ≥10% tumour cells were immunoreactive for p21. p21 expression was noted and correlated with T-stage, nodal metastasis, perineural and depth of invasion, recurrence and 2-year survival rate. Results: Of 110 cases, p21-positive cases were 88 (80%) compared to 22 (20%) negative. T1–T2 tumours with p21 expression were 59 (67.04%) while 17 cases (77.27%) had negative for p21 (P = 0.44). Amongst T3–T4, 29 cases showed p21 expression (32.96%) while 5 cases (22.73%) were negative (P = 0.44). Nodal metastasis was seen in 51 cases (57.95%) with p21 positivity as compared to 4 cases (18.8%) with no p21 expression (P = 0.0015). Perineural invasion was seen in 15 carcinomas (17.04%) having p21 positivity and 1 case (4.54%) with p21 negativity (P = 0.18). 48 cases (54.54%) had depth of invasion >1 cm with positive p21 as compared to 4 cases (18.18%) without (P value = 0.0035). 39 cases (44.31%) showed recurrence along with p21 expression while 3 cases (13.63%) showed recurrence without (P = 0.0076). 2-year survival rate was 56.81% (n = 88) in p21 positive cases, whereas it was 90.90% (n = 20) those with negative p21 (P = 0.0026). Conclusion: Positive p21 expression in HNSCC correlates with intermediate grade, late stage, increased nodal metastasis, tumour recurrence and decreased survival. p21 should be considered as an important prognostic and predictive marker in HNSCC to detect tumours at early stage and to improve therapy and prognosis. Key words: Head and neck squamous cell carcinoma, lymph node metastasis, p21, recurrence, survival rate
PAEDIATRIC ONCOLOGY IN PAKISTAN: TIME FOR COLLABORATIVE CLINICAL TRIALS
Authors: Maaz Ata
Published: December 2019

-
SMARCB1 (INI-1) DEFICIENT POORLY DIFFERENTIATED CARCINOMA OF SINONASAL TRACT
Authors: Hassan Usman , Hussain Mudassar
Published: December 2019

-
ORAL METHOTREXATE AS SECOND LINE CHEMOTHERAPY IN PLATINUM-REFRACTORY OR RELAPSED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Authors: Irfan Muhammad , Jamshed Arif , Haider Irfan , Hussain Raza
Published: December 2019

Purpose: Platinum-refractory or relapsed squamous cell carcinoma of the head and neck (SCCHN) is considered to have poor prognosis. Although cetuximab is currently recommended as category 1 in this group of patients, the use of it is hampered in low- and middle-income countries (LMICs) like Pakistan due to nancial constraints. Further, majority of the population of these countries is unable to tolerate toxicity related to other intravenous chemotherapeutic agents due to lower socioeconomic background with poor nutrition status. The aim of this study is to evaluate the response rate and toxicity of oral methotrexate (MTX) in platinum-refractory or relapsed SCCHN. Methods: Between June 2008 and December 2012, 71 patients received palliative oral MTX either due to recurrent or persistent disease. With a median age of 51 years (range 22–75), there were 68% of males and 32% of females. Site distribution was as following; oral cavity 58%, nasopharynx 25%, hypopharynx 7%, paranasal sinuses 6%, larynx 3%, Oropharynx 1%. Patterns of recurrence; local 32%, regional 07%, loco regional 10%, distant 15% and persistent disease in 36% of the patients. All the patients received oral MTX 10 mg once a day, 4 days a week. To contain the possible side effects associated with MTX, folinic acid 15 mg per oral every 6 hourly on day 5 was prescribed. Response assessment was done on two monthly basis. Response, toxicity, mean response time and mean time to progression were determined. Results: Response to MTX was as following; complete response 3%, partial response 4%, stable disease 11% and progressive disease in 82% of the patients respectively. Toxicity related to oral MTX includes neutropenia Grade III in 1% while mucositis Grade III in 10% of the patients, respectively. None of the patient had Grade IV mucositis or haematological toxicity. Treatment was stopped in 13% of the patients due to poor compliance. Mean response time was 4 months (range 1 – 20) and mean time to progression was 5 months (range 1–23). Conclusion: Oral MTX is a simple, cost-effective and well-tolerated regimen to be used on outpatient basis for palliation in platinum refractory or relapsed SCCHN in LMICs and debilitated patients. This treatment merits further evaluation in large-scale clinical trials. Key words: Oral methotrexate, platinum refractory, relapsed squamous cell carcinoma of head and neck
ALVEOLAR RHABDOMYOSARCOMA OF SINONASAL TRACT
Authors: Akhtar Noreen , Sadaf Safana , Mushtaq Sajid
Published: December 2019

-
ENSURING QUALITY OF LIFE OF CANCER PATIENTS THROUGH OPTIMAL ORAL HEALTH
Authors: Chaudhry Saima , Khan Ayyaz Ali
Published: December 2019

-
MOST CANCERS ARE CAUSED BY BAD LUCK MUTATIONS: SCIENTIFIC EXPLANATION?
Authors: Pervez Shahid
Published: December 2019

-
PENGETAHUAN DAN PENERAPAN SASARAN KESELAMATAN PASIEN PADA MAHASISWA SEMESTER 6 DI AKADEMI KEPERAWATAN ADI HUSADA SURABAYA
Authors: Iswati Iswati
Published: December 2019

Patient safety incident can be done by nursing students when doing clinical practice in hospitals. This happens because of a lack of knowledge about patient safety. The purpose of this study was to identify the relationship between knowledge of patient safety with the implementation of patient safety in the 6th semester student at the Academy of Nursing Adi Husada Surabaya. This type of research is correlational, variable research is knowledge of patient safety and patient safety application. Total population of 143 and the number of samples is 131. The sampling technique is used directly probability sampling type simple random sampling. Measuring instruments used questionnaires and observation sheets. Data analysis using the spearman rank test, (α= 0.05,p=0.01,r= 0.817) indicating Ho refused meaning that there is a relationship between knowledge and application of patient safety. Results of the study recommended the need for the provision of special courses on patient safety for students in the 6th semester nursing Academy Adi Husada Surabaya.

Insiden keselamatan pasien dapat dilakukan oleh mahasiswa saat melakukan praktik klinik di rumah sakit. Hal ini terjadi karena kurangnya pengetahuan tentang keselamatan pasien. Tujuan penelitian ini untuk mengidentifikasi hubungan antara pengetahuan tentang keselamatan pasien dengan penerapan keselamatan pasienpadamahasiswa semester 6 di Akademi Keperawatan Adi Husada Surabaya. Jenis penelitian ini adalah korelasional, variable penelitiannya adalah pengetahuan tentang keselamatan pasien dan penerapan keselamatan pasien. Jumlah populasi sebanyak 143 dan jumlah sampel adalah 131. Teknik sampling yang digunakan adalah probability sampling jenis simple random sampling. Alat ukur yang digunakan kuesioner dan lembar observasi. Analisis data menggunakan Spearman Rank Test, (α=0.05, p= 0.01, r=0.817)  hal ini menunjukkan Ho ditolak artinya terdapat hubungan antara pengetahuan dan penerapan keselamatan pasien. Hasil penelitian merekomendasikan perlunya pemberian mata kuliah khusus tentang keselamatan pasien bagi mahasiswa semester 6 di Akademi Keperawatan Adi Husada Surabaya.

DOWNLOAD FULL TEXT PDF >>
Discovery of a Disrupting Open Cluster Far into the Milky Way Halo: A Recent Star Formation Event in the Leading Arm of the Magellanic Stream?
Authors: Price-Whelan Adrian M. , Nidever David L. , Choi Yumi , Schlafly Edward F. , Morton Timothy , Koposov Sergey E. , Belokurov Vasily
Published: December 2019

We report the discovery of a young (

), low-mass (

), metal-poor (

) stellar association at a heliocentric distance

, placing it far into the Milky Way (MW) halo. At its present Galactocentric position

, the association is (on the sky) near the leading arm of the gas stream emanating from the Magellanic Cloud system, but is located

from the Large Magellanic Cloud center on the other side of the MW disk. If the cluster is colocated with H i gas in the stream, we directly measure the distance to the leading arm of the Magellanic stream. The measured distance is inconsistent with Magellanic stream model predictions that do not account for ram pressure and gas interaction with the MW disk. The estimated age of the cluster is consistent with the time of last passage of the leading arm gas through the Galactic midplane; we therefore speculate that this star formation event was triggered by its last disk midplane passage. Most details of this idea remain a puzzle: the Magellanic stream has low column density, the MW disk at large radii has low gas density, and the relative velocity of the leading arm and MW gas is large. However it formed, the discovery of a young stellar cluster in the MW halo presents an interesting opportunity for study. This cluster was discovered with Gaia astrometry and photometry alone, but follow-up DECam photometry was crucial for measuring its properties.
On the Prospect of Using the Maximum Circular Velocity of Halos to Encapsulate Assembly Bias in the Galaxy–Halo Connection
Authors: Zehavi Idit , Kerby Stephen E. , Contreras Sergio , Jiménez Esteban , Padilla Nelson , Baugh Carlton M.
Published: December 2019

We investigate a conceptual modification of the halo occupation distribution approach, using the halos’ present-day maximal circular velocity, V
max, as an alternative to halo mass. In particular, using a semianalytic galaxy formation model applied to the Millennium WMAP7 simulation, we explore the extent that switching to V
max as the primary halo property incorporates the effects of assembly bias into the formalism. We consider fixed number density galaxy samples ranked by stellar mass and examine the variations in the halo occupation functions with either halo concentration or formation time. We find that using V
max results in a significant reduction in the occupancy variation of the central galaxies, particularly for concentration. The satellites’ occupancy variation on the other hand increases in all cases. We find effectively no change in the halo clustering dependence on concentration, for fixed bins of V
max compared to fixed halo mass. Most crucially, we calculate the impact of assembly bias on galaxy clustering by comparing the amplitude of clustering to that of a shuffled galaxy sample, finding that the level of galaxy assembly bias remains largely unchanged. Our results suggest that while using V
max as a proxy for halo mass diminishes some of the occupancy variations exhibited in the galaxy–halo relation, it is not able to encapsulate the effects of assembly bias potentially present in galaxy clustering. The use of other more complex halo properties, such as V
peak, the peak value of V
max over the assembly history, provides some improvement and warrants further investigation.
Two New “Turn-off” Changing-look Active Galactic Nuclei and Implication on “Partially Obscured” AGNs
Authors: Wang J. , Xu D. W. , Wang Y. , Zhang J. B. , Zheng J. , Wei J. Y.
Published: December 2019

We report a spectroscopic identification of two new changing-look active galactic nuclei (CL-AGNs): SDSS J104705.16+544405.8 and SDSS J120447.91+170256.8, both with a “turn-off” type transition from type-1 to type-1.8/1.9. The identification is arrived at through a follow-up spectroscopic observation of the five CL-AGNs candidates that are extracted from the sample recently released in Macleod et al. The candidates are extracted by the authors from the Sloan Digit Sky Survey Data Release 7, and are spectroscopically confirmed quasars with large amplitude variability. By compiling a sample of 26 previously identified CL-AGNs, we confirm the claim by Macleod et al. that CL-AGNs tend to be biased against a low Eddington ratio, and identify an overlap between the CL-AGNs at their dim state and the so-called intermediate-type AGNs. The overlap implies that there two populations of the intermediate-type AGNs with different origins. One is due to the torus orientation effect, and the other to the intrinsic change of the accretion rate of the central supermassive black holes.
Revealing Hidden Substructures in the MBH–σ Diagram, and Refining the Bend in the L–σ Relation
Authors: Sahu Nandini , Graham Alister W. , Davis Benjamin L.
Published: December 2019

Using 145 early- and late-type galaxies (ETGs and LTGs) with directly measured supermassive black hole masses, M
BH, we build upon our previous discoveries that: (i) LTGs, most of which have been alleged to contain a pseudobulge, follow the relation

M

BH

∝

M

*
,
sph

2.16
±
0.32

; and (ii) the ETG relation

M

BH

∝

M

*
,
sph

1.27
±
0.07

is an artifact of ETGs with/without disks following parallel

M

BH

∝

M

*
,
sph

1.9
±
0.2

relations that are offset by an order of magnitude in the M
BH direction. Here, we searched for substructure in the diagram of M
BH versus central velocity dispersion σ, using our recently published multi-component galaxy decompositions, by investigating divisions based on the presence of a depleted stellar core (major dry merger), a disk (minor wet/dry merger, gas accretion), or a bar (evolved unstable disk). The Sérsic and core-Sérsic galaxies define two distinct relations:

M

BH

∝

σ

5.75
±
0.34

and

M

BH

∝

σ

8.64
±
1.10

, with

Δ

rms
∣
BH

=
0.55

and 0.46 dex, respectively. We also report on the consistency with the slopes and bends in the galaxy luminosity (L)–σ relation due to Sérsic and core-Sérsic ETGs, and LTGs that all have Sérsic light profiles. Two distinct relations (superficially) reappear in the M
BH–σ diagram upon separating galaxies with/without a disk (primarily for the ETG sample), while we find no significant offset between barred and non-barred galaxies, nor between galaxies with/without active galactic nuclei. We also address selection biases purported to affect the scaling relations for dynamically measured M
BH samples. Our new M
BH–σ relations, dependent on morphological type, more precisely estimate M
BH in other galaxies, and hold implications for galaxy/black hole coevolution theories, simulations, feedback, the pursuit of a black-hole fundamental plane, and calibration of virial f-factors for reverberation mapping.
Silene sunhangii (Caryophyllaceae), a new species from China
Authors: Lin Nan , Zhang Dai-Gui , Huang Xian-Han , Zhang Jian-Wen , Yang Jing-Yuan , Tojibaev Komiljon , Wang Heng-Chang , Deng Tao
Published: December 2019

Silene sunhangii, a new species of Caryophyllaceae known from only three populations in Hubei and Hunan provinces of central China, is described. Both morphological and molecular data were used to assess the taxonomic status and relationships of this species. Morphologically, S. sunhangii is most similar to S. platyphylla Franch. from which it differs most readily in having 3-veined elliptical leaves without pubescence, tasseled catacorolla, pale purple to red petals without a linear lobe or narrow tooth and lanceolate, bifid to one third. A phylogenetic analysis based on nuclear ITS region identified the new species as a well-supported, independent lineage. Our new species is nested within a grade that encompasses species representing a polyphyletic Silene sect. Physolychnis (Benth.) Bocquet. Both the genetic and morphological data support the recognition of Silene sunhangii as a distinct species, although there is inconsistency between these two datasets as to the relationships of the new species.
Simples passeurs ou créateurs ? Les dirigeants du sport communiste français face au modèle sportif de l’Est (1923-1991)
Authors: Martinache Igor
Published: December 2019

Le contexte de « Guerre froide » qui a polarisé une grande partie du monde, mais aussi chacune des sociétés nationales, pendant près de 7 décennies au 20 e siècle n’a pas épargné les activités physiques et sportives en dépit de l’aura d’apolitisme qui les entoure. En France par exemple, la lutte des classes s’est réfractée sur les terrains sportifs dès le début des années 1920 avec la création de la Fédération sportive du travail (FST), affiliée à l’Internationale rouge des sports (IRS) dont le siège était à Moscou. Son remplacement par la Fédération sportive et gymnique du travail (FSGT) en 1934 suite à la réconciliation des deux principales branches, communiste et « réformiste », du mouvement ouvrier s’est aussi traduit par la substitution du mot d’ordre de « sport rouge » par celui de « sport populaire ». L’ouverture internationale, en particulier vers les pays « frères » du Bloc de l’Est ne s’est pas perdue pour autant, et a emprunté des canaux divers : rencontres sportives ponctuelles, tournées d’athlètes et de dirigeants, correspondances à long terme, mais aussi circulation d’idées et de textes doctrinaux. A rebours d’une représentation superficielle présentant la sphère d’influence soviétique et les partis communistes nationaux en son sein comme des ensembles monolithiques et verticaux, cette contribution propose de montrer la réciprocité et la complexité des circulations humaines et idéelles dans la sphère du bloc communiste. À partir de l’analyse comparée des trajectoires biographiques d’un certain nombre de dirigeants du « sport communiste » en France à différentes périodes, nous défendons en particulier la thèse selon laquelle l’évolution des positions diplomatiques et doctrinales des organisations concernées (en particulier la FSGT et le Parti communiste français) ne découlent pas simplement de celles de Moscou, mais présente une certaine autonomie et ont même exercé réciproquement une relative influence vers l’Est. Ce faisant, à partir d’un cas particulier mais paradigmatique, ce texte suggère que les acteurs de l’internationalisation du sport ne se résument pas aux seuls dirigeants des organisations sportives internationales.
Ohene Djan. Un militant panafricaniste à la conquête de la FIFA ?
Authors: Nicolas Claire , Vonnard Philippe
Published: December 2019

En 2004, le stade national d’Accra est renommé stade Ohene Djan, ce geste devant permettre de commémorer l’action du premier directeur des sports du Ghana (1960-1966). Cependant, six ans plus tard, la municipalité d’Accra revient sur ce choix des autorités nationales, argumentant qu’il s’agit d’un stade municipal et non d’un stade national pour justifier cette décision. Si Ohene Djan fait encore parler de nos jours, c’est que sans doute que son action a largement dépassé les frontières du Ghana. En effet, nommé directeur des sports du Ghana en 1960 par Kwame Nkrumah, ce dernier a incarné durant les six ans de son mandat l’irruption d’enjeux politiques proprement africains au sein du football mondial, et a œuvré à reconfigurer des relations diplomatiques sportives jusque-là largement cantonnées à l’Europe et à l’Amérique du Sud. Dans le cadre de cette contribution, il s’agit de penser le parcours biographique de Djan comme un point de rencontre entre les footballs - national et global - d’une part et entre une trajectoire politique et sportive d’autre part. Moins que le récit de la chronologie d’un parcours biographique rythmé par des étapes organisationnelles, politiques, personnelles et sportives, cet article considère Djan comme le nœud qui nous permet d’interroger le modèle sportif et politique de la FIFA, revendiqué comme apolitique et élitaire. La présente recherche s’appuie sur une documentation collectée dans les riches archives de la Fédération internationale de football association (FIFA) qui a été croisée par des informations issues des fonds des Archives nationales du Ghana. Enfin, l’étude bénéficie de la lecture de journaux sportifs et généralistes ghanéens, qui permettent de mettre en lumière des éléments qui ne sont pas traités dans les documents officiels de la FIFA ou dans les archives nationales ghanéennes, mais aussi d’avoir un regard sur la présence publique de Djan.
Entre fidélité olympique et nationale. Le cas du membre du CIO Alberto Bonacossa
Authors: Sbetti Nicola
Published: December 2019

Le comte Alberto Bonacossa (Vigevano 24.8.1883 – Milan 30.1.1953) est l’un des plus importants et influents dirigeants sportifs italiens au XX e siècle. Il va ainsi occuper des fonctions à différentes époques de la période libérale de l’Italie à la République, en passant par la période fasciste. Pour ne citer que ses engagements internationaux il fut notamment président de la Fédération internationale de motocyclisme, vice-président de celle des Automobile-clubs, membre de la Ligue international du hockey sur glace et de l’International Skating Union, mais surtout, à partir du 1925 membre du CIO et (dès 1935) de son Comité exécutif. Dès lors l’ambition de notre article est d’analyser en détail les étapes de la carrière d’Alberto Bonacossa, en particulier pour saisir l’importance de son appartenance à une noblesse italienne dans le cadre de son engagement dans des réseaux sportifs internationaux dominés par une culture qui était en même temps cosmopolite, transnationale et patriotique/nationaliste. Nos analyses reposent notamment sur les archives du comité national olympique italien (CONI) et sur les archives du CIO, et celles-ci doivent permettre de souligner comme les tensions entre le national et l’international se réactualise singulièrement au sein des organisations sportives internationales, autour de certaines biographies.