bluuebunny/crossref_metadata_2025 huggingface dataset:
The Lived Experiences of Pregnant Women During COVID-19 Pandemic: A Descriptive Phenomenological Study
Authors: Mortazavi Forough , Ghardashi Fatemeh
Published: November 2020

BackgroundWith the onset of the COVID-19 epidemic, pregnancy and childbirth for women are taking place in unusual circumstances. We explored the lived experiences of pregnant women during the COVID-19 pandemic to better understand their experience of pregnancy so that better support could be provided.MethodsWe used a descriptive phenomenological approach to understand the lived experience of pregnant women in COVID-19 pandemic. We collected data using a purposive sampling method through in-depth interviews in cyberspace with a semi-structured questionnaire. We used Colaizzi’s seven-step content analysis method to analyze the research data with the help of MAXQDA software version 2020.ResultsWe conducted this descriptive phenomenology study on 19 pregnant women in a period between the 10th to the 20th of May, 2020. The participating women were already pregnant when the first signs of the epidemic appeared in the country and at the time of the interview. We acquired four themes including disruption of the tranquility and regular routines of daily life, new challenges caused by the epidemic, resilience and strength in facing the crisis, and adaptation with new conditions.ConclusionsThe psychological condition of women has deteriorated during the COVID-19 epidemic. The general mobilization the health system is necessary for alleviating pregnant women's difficulties in situations like the COVID-19 epidemic. Planning to establish virtual training classes, virtual counseling, and creating a safe and supportive community environment are among the most effective ways to enhance the peace and tranquility of pregnant women.
Hepatitis B Virus Antibody as Potential Biomarker to Predict the Effect of Rituximab in Diffuse Large B-cell Lymphoma Patients
Authors: Hu Shunfeng , Chen Na , Lu Kang , Zhen Changqing , Sui Xiaohui , Fang Xiaosheng , Li Ying , Zhou Xiangxiang , Wang Xin
Published: November 2020

Background: Diffuse large B-cell lymphoma (DLBCL) has been correlated with virus infection and immunity status. Hepatitis B virus (HBV) infection is a significant public health problem around the world, especially in China. Previous research regarding the association of non-Hodgkin lymphoma (NHL) and HBV mostly focused on HBV antigen and HBV DNA. This study aimed to evaluate the relationship between HBV antibody and clinical prognosis in DLBCL. Methods: We retrospectively investigated the clinical characteristics of 190 newly diagnosed and untreated DLBCL patients and did a follow-up study. Results: Compared with HBeAb- patients, HBeAb+ patients displayed unique clinical features, such as more advanced disease stage (p=0.031) and higher International Prognostic Index (IPI) score (p=0.015). HBV antibody-negative patients had better therapeutic efficiency than positive patients (p<0.05). The media progression-free survival (PFS) and overall survival (OS) of HBV antibody-positive group were shorter than the negative group, respectively (p<0.05). Furthermore, we found positive association between CD21 and HBsAb (p=0.06) and their synergistic effect for prognostic predication. Interestingly, the effect of Rituximab in prognostic improvement was more significant in HBV antibody-positive group than negative group. Univariate analysis showed that HBV antibody status was independent risk factor for prognosis of DLBCL patients. Conclusions: Taken together, our investigations identified for the first time the close association between HBV antibody and clinical prognosis and Rituximab responses in DLBCL patients. These findings indicate the novel association between HBV infection and DLBCL prognosis, provide potential biomarker to predict the effect of Rituximab, and offer novel insights into the role of immune response to HBV infection in DLBCL progression.
LncRNA NORAD promotes the progression of myocardial infarction by targeting miR-22-3p/PTEN axis
Authors: Li Chunxia , Zhang Lihui , Bu Xingpeng , Chu Guofang , Zhao Xiaofang , Liu Yaru
Published: November 2020

Increasing evidences have demonstrated that lncRNAs are closely associated with the progression of acute myocardial infarction (AMI). Although lncRNA NORAD has been reported to be highly expressed in MI patients, its specific function remains unclear. Here, we found that downregulation of NORAD efficiently attenuated heart damage in an AMI rat model. Meanwhile, silencing of NORAD also inhibited hypoxia/re-oxygenation (H/R)-treated mouse cardiomyocyte cell line HL-1 cells. Further, bioinformatics analysis revealed that NORAD might act as a ceRNA of miR-22-3p, and PTEN was a potential target of miR-22-3p. Then luciferase reporter assay was performed to confirm that NORAD could upregulate PTEN by directly sponging miR-22-3p. Meanwhile, miR-22-3p inhibitor significantly reversed si-NORAD induced inhibitory effect on the apoptosis of H/R-treated HL-1 cells, and overexpression of PTEN could obviously reverse miR-22-3p mimics induced inhibitory effect on the apoptosis of H/R-treated HL-1 cells. Meanwhile, miR-22-3p mimics significantly reversed OE-NORAD (overexpression of NORAD) induced expression of p-AKT and p-mTOR. In a word, our results suggested lncRNA NORAD might promote the progression of myocardial infarction by promoting PTEN/AKT/mTOR signaling pathway through directly sponging miR-22-3p, suggesting that NORAD might be a potential target for AMI treatment.
Covid-19 Pandemic Impact on Maternal and Child Health Services Access in Nampula, Mozambique: A Mixed Methods Research.
Authors: Pires Paulo das Neves , Macaringue Cynthia , Abdirazak Ahmed , Mucufo Jaibo , Mupueleque Martins , Siemens Ronald , Belo Celso
Published: November 2020

BackgroundThe Covid-19 pandemic limited access to health services in most countries, impacting negatively global health. Last March 2020 in Mozambique, a public state of emergency restrained people’s movements, reduced public services, and launched a national information campaign. The Alert Community for a Prepared Hospital implementation research, has been promoting access to maternal and child health care, at Marrere General Hospital and Marrere Health Centre, in Natikiri, Nampula, the city with the third highest incidence of Covid-19 in Mozambique. Our research aimed to assess the impact of Covid-19 on access to maternal and children health services in Nampula and estimate Alert Community for a Prepared Hospital project sustainability.MethodsMixed-methods research, descriptive, cross-sectional, and retrospective, using review of patient visits documentation, comparing March to May 2019 to same months in 2020, and interviews with health professionals, traditional birth attendants and patients. We involved two health centres and two hospitals. The two Marrere centres were Alert Community for a Prepared Hospital intervention centres, and the other two were control centres, compared using KrushKall Wallis, One-way Anova, mean and standard deviation tests.ResultsComparing 2019 maternal health services indicators with those from 2020, the intervention area had decreases of 28% in family planning visits, 26% in women in first ante-natal visits in the first trimester, and a 74% increase in home deliveries, all without statistical significance. The decrease in hospital maternity deliveries (4%) was statistically significant (p=0.046). The non-intervention area showed a decrease in women in first ante-natal visits in the first trimester (12%). Concerning child health, the intervention area had a 20% reduction in children presenting for vaccination and an 18% in children completely vaccinated, comparable to a reduction of 16% in the non-intervention area. Interviews revealed that most health professionals, traditional birth attendants and patients, have adequate knowledge about Covid-19. ConclusionOur results demonstrate negative collateral effects of Covid-19 on maternal and child health access and a deficient health information system in Mozambique. The Government’s media campaign promoting access to preventive health services, is not achieving its aim. The Alert Community project will need further research, to assess lasting effect on reducing the negative effects of Covid-19 on sexual and reproductive health.Trial registrationThis study was not registered in any data base.
Measuring equity of access to health services in practice: test and application of existing measuring tools in eye health outreach camps in rural Malawi
Authors: Trotignon Guillaume , Jones Iain , Ali Shaneez Saeed , Mugwang’a Ziporah , Engels Thomas , Bechange Stevens , Kamwendo Effie , Schmidt Elena , Adera Tesfaye Haileselassie
Published: November 2020

Introduction: Equity in the access and use of health services is critical if countries are to make progress towards universal health coverage and address the systematic exclusion of the most vulnerable groups. The purpose of this study was to test the feasibility of existing wealth measurement tools and functional disability questions to assess if the Co-ordinated Approach To Community Health programme implemented by Sightsavers was successful in reaching the poorest population and people living with disabilities in Kasungu district, Malawi. Methods: Between April and September 2017, data on socio-economic status, household characteristics and functional disability were collected from patients attending at eye camps in Kasungu district, Malawi. Using asset-based tools to measure household wealth (EquityTool© and Simple Poverty Scorecard©) and the Washington Group Short Set of Questions, individuals were categorised by wealth quintiles, poverty status, and functional disability status and then compared to relevant representative national household surveys. A follow-up household survey was conducted to check the validity of self-reported household characteristics at eye camps. Results: A total of 1,358 individuals participated in the study. The study shows that self-reported data on household characteristics and assets are reliable and can be collected in clinical settings (instead of relying on direct observations of assets). Individuals attending outreach camps were poorer in terms of relative wealth and absolute poverty rates compared to the rest of the population in Kasungu. It was estimated that 9% of the participants belonged to the poorest quintile compared to 4% for the population in Kasungu (DHS 2015-2016). The ultra-poverty rate was also lower among respondents (13%) compared to 15% for Kasungu district (IHS 2017). The functional disability rate was 27.5% for study participants, and statistically higher than the general population (5.6%, SENTIF 2017). Conclusions: Our study shows that existing tools can be reliably used, and combined, if based on recent population data, to assess equity of access to health services for vulnerable groups of the population. The findings suggest that the programme was successful in reaching the poorest people of the Kasungu district population as well as those with disabilities through outreach camps. However, it is essential to use sub-national data (district or regional level) from recent surveys for the purpose of benchmarking in order to produce accurate results.
Phase diagram of the $\mathbb{Z}_3$-Fock parafermion chain with pair hopping
Authors: Mahyaeh Iman , Wouters Jurriaan , Schuricht Dirk
Published: November 2020

We study a tight binding model of \mathbb{Z}_3ℤ3-Fock
parafermions with single-particle and pair-hopping terms. The phase
diagram has four different phases: a gapped phase, a gapless phase with
central charge \boldsymbol{c=2}𝐜=2,
and two gapless phases with central charge
\boldsymbol{c=1}𝐜=1.
We characterise each phase by analysing the energy gap, entanglement
entropy and different correlation functions. The numerical simulations
are complemented by analytical arguments.
Indonesian Tourists’ Perception regarding Singapore’s Tourism Television Commercial
Authors: Yusuf Mohamad , Santoso Edward Giordan
Published: November 2020

The research aimed to highlight the impact of the television commercial (TVC) on Indonesians’ perceptions regarding tourism in Singapore and their behavioral intention to visit Singapore. The research had five variables: hospitality and comfort/security, infrastructures and superstructures, cultural and natural attractions, perceived values, and behavioral intention. It utilized a quantitative method. About 267 samples were collected using a random sampling method. Data analysis was drawn from the mean difference for each variable. The findings indicate that the TVC has positive impacts on the studied variables. The result implies that understanding tourists’ perceptions about Singapore as a travel destination will help the stakeholders to formulate appropriate marketing strategies and position it as a destination choice. However, further research needs to highlight how each variable influences tourists’ behavioral intention to revisit Singapore.
The Effectiveness of Blended Learning in Improving Students’ Workplace Communication Skills: A Case Study on Olive Website Test Result
Authors: Tyas Agnes Siwi Purwaning , Muam Ahmad , Sari Yohana Ika Harnita , Dewantara Cisya
Published: November 2020

The research aimed to investigate the effectiveness of using blended-learning instruction in improving students’ communication skills at Sekolah Vokasi Universitas Gadjah Mada. They were required to take the Test of English for Vocational Students (TEVOCS) and it indicated that there was a gap between listening and speaking ability as presented in the test scores. To support the improvement of both skills, blended-learning instruction was designed and carried out in the forms of online listening activities via Online Listening for Individual Practice (OLIVE) website and offline meeting for speaking activities. The research used experimental research, which referred to the results of pre-test and post-test scores of the group. The participants of the research were 275 students from three departments of Sekolah Vokasi Universitas Gadjah Mada; Language, Arts, and Cultural Management department; Engineering department; as well as Economic and Business department academic year 2019/2020. The pre-test and post-test scores show improvement in students’ performance in both skills. The result of the t-test also shows that there is significant improvement after the application of blended-learning instruction.
Reflection of Undergraduate Students on Translation Process: An Outlook of Translation Teaching in University
Authors: Siregar Roswani , Risnawaty Risnawaty , Arfanti Yulia , Sembiring Milisi
Published: November 2020

The research attempted to recognize students’ comprehension in adopting a set of procedures in the translation process compared to the translation-professional choices in real-situation. Thus, two sets of questionnaires were provided for students and professional translators. The qualitative method was employed in conducting the research. The first questionnaire enabled students to express their feelings, thoughts, and ideas concerning the translation course and process. This reflection revealed the students’ strategies, interests, and motivation in attending the course. It also allowed the student to see the importance and benefit of the course. On the other hand, the second questionnaire drew some insight into professional translators’ choice in doing a translation, particularly on strategy in dealing with texts. Those finding provides an opportunity for teachers to identify the students’ needs in learning and practicing the translation as close as the professional does and finally to find the best approach in teaching translation.
Errors Analysis of Directive Speech Act and Politeness Strategy in Kaiwa Chukyu Learning
Authors: Diner Lispridona
Published: November 2020

The research aimed to explain types of directive speech act encompassed meirei (order), irai (plea), kinshi (prohibition), kyoka (permit), and teian (suggestion) in the Japanese language. Directive speech acts were common for students in the kaiwa chukyu zenhan level (basic intermediate speaking lesson). The present research employed a listening method with the basic technique, i.e., tapping method. Further, involved and uninvolved conversation observation techniques, note-taking, and recording were applied to collect the data. The data object was the documentation of student conversations in class. The data, consisting of the directive speech act of the politeness principles in the conversation during the Japanese course kaiwa chukyu zenhan, were analyzed using an identity method. In conclusion, the research identifies several directive speech acts that are used during the class. Those are zenhan (order, three data), requesting (two data), suggesting (one data), prohibiting (one data), and permitting (one data). Moreover, the honorifics used include the teineigo and kenjogo. Among the nine data, directive speech acts are identified in the class, and only one data indicates the indirect speech act.
I am falling in love, Ouch!: Ontological metaphors at work
Authors: Roselani Ni Gusti Ayu
Published: November 2020

The research aimed to track the distribution of in metaphors and explore their ontological function in the abstracts of English research articles in the sub-disciplines of theoretical linguistics and pragmatics. The lack of empirical evidence on the subject had become the inspiration to base the research on a corpus. The corpus consisted of 40 research article abstracts; 20 from Journal of Linguistics and another 20 from Journal of Pragmatics. By using a quantitative method, the results show that theoretical linguistics abstracts are more densely populated with ‘in’ metaphors. However, in terms of in-preposition phrase topic complement variations, they are less varied. Qualitatively, the results confirm a notion proposed by Conceptual Metaphor Theory (CMT) that ‘in’ metaphors function cognitively by providing ontological status to abstract objects. Their existence proves to play an important role in academic texts.
The Relationship between Metacognitive Awareness and Receptive Skills of University Students
Authors: Erda Ayu Marsela
Published: November 2020

The research investigated the influence of metacognitive awareness on receptive skills in higher education students. Moreover, participants’ level of metacognitive awareness was also taken into account. The research utilized a survey in the form of Metacognitive Awareness Listening Questionnaire (MALQ) and Metacognitive Awareness Reading Strategy Inventory (MARSI) and test of listening and reading comprehension to collect the data and multiple regression to analyze it. The participants were 59 English educational students in the first semester of a public university in Yogyakarta. The finding shows there is a significant influence of metacognitive awareness on receptive skills. However, there is the only significant influence of metacognitive awareness on reading skills. In contrast, there is no significant influence of metacognitive awareness on listening skills. Most of the students are categorized at a high level of metacognitive awareness in listening and reading. However, they have relatively poor scores in the D and E categories for both listening and reading comprehension tests. The only skill which has a significant influence on metacognitive awareness is reading skills. Therefore, the findings show that there is no significant influence of metacognitive awareness on listening skills. However, there is a significant influence of metacognitive awareness on reading skills. Further research needs to be conducted to reveal the different influences between reading and listening skills related to metacognitive awareness, as found in the research.
The Modern Russian Historiography of the Evacuation of Industry during the Great Patriotic War and New Prospects for Research
Authors:   Nosov Magnitogorsk State Technical University, Potemkina M. N. ,   The Russian Presidential Academy of National Economy and Public Administration, Klimanov A. Yu. ,   The Russian Presidential Academy of National Economy and Public Administration,   National Research University “Higher School of Economics”
Published: November 2020

The article analyzes contemporary Russian historiography on the evacuation of indsutries during the Great Patriotic War. Particular attention is paid to digital data cited by researchers about the number of industrial enterprises from different economic sectors evacuated into the rear as one of the most important characteristics of the USSR military economy. The absence of comprehensive work on the evacuation of material resources into the country’s rear remains problematic. The article provides a comparison of central and regional studies of Siberia, the Volga region, and the Urals. The conclusion is drawn on the significant successes of regional historiography in studying a number of problems in organizing the relocation and placement of industrial enterprises in new places, commissioning, economic efficiency of evacuated industrial equipment, and consequences of evacuation for strengthening the Soviet rear. The points under consideration concern the main achievements and debatable issues in the study of industrial evacuation, as well as the characteristics of the prospects for this scientific problem studying. The necessity of intensifying research on such aspects. Among these aspects are the following: the influence of pre-war mobilization plans on the organization of evacuation during the war, identifying the share of equipment losses during evacuation and explanations for such losses, the creation and functioning of evacuation bases, the evacuation of design bureaus and their impact on modernization processes on evacuated factories, and the post-war fate of the evacuated equipment.
A história que se repete
Authors: Ott Werner Paul , Ott (UERGS) Paulo Henrique
Published: November 2020

Ensaio
Potencial do cultivo de videiras destinadas a elaboração de suco de uva em Lages, Planalto Sul de Santa Catarina
Authors: Würz Douglas André , Marcon Filho José Luiz , Canossa Adrielen Tamiris , Reinehr Juliana , Rufato Leo , Allebrandt Ricardo , De Bem Betina Pereira , Brighenti Alberto Fontanella
Published: November 2020

A região de Lages, Santa Catarina, possui grande potencial para o cultivo de espécies frutíferas de clima temperado e nesse contexto o cultivo de uvas para processamento surgem como alternativa viável para geração de renda e emprego na região, atendendo uma demanda existente no estado de Santa Catarina. Diante disto, tem-se como objetivo deste trabalho, avaliar o potencial produtivo e qualitativo de três variedades de uvas para processamento cultivadas em Lages, Planalto Sul de Santa Catarina, Brasil. O presente estudo foi realizado em um vinhedo experimental localizado no munícipio de Lages, durante as safras 2015/2016 e 2016/2017. Foram avaliadas plantas de Vitis labrusca, variedades Bordô, Concord e Isabel Precoce. Avaliou-se: fenologia, desempenho produtivo, arquitetura de cacho e maturação tecnológica. Apesar de possuir adequada maturação tecnológica, a variedade Bordô apresentou baixa produtividade, sendo esta, a variedade avaliada de maior precocidade para brotação, floração e verásion, no entanto, na mesma data de colheita, a variedade Isabel Precoce apresenta maior acumulo de sólidos solúveis, além de destacar-se pela maior produtividade e bom índice de fertilidade. A maior compactação de cachos foi observada nas variedades Isabel Precoce e Concord, enquanto as demais variáveis de arquitetura de cacho apresentaram valores distintos entre as safras avaliadas.
Planos municipais de mata atlântica
Authors: Petrykowski Peixe Sarah , Silva Pereira Mello Ricardo
Published: November 2020

O Bioma Mata Atlântica é reconhecido por seus inestimáveis valores culturais, ecológicos e econômicos, mas, ao mesmo tempo, se apresenta altamente reduzido e fragmentado. O desenvolvimento de estratégias para a gestão deste patrimônio é uma necessidade iminente, e o engajamento em âmbito municipal tem papel essencial na sua conservação. Esse artigo propõe sistematizar os principais aspectos legais, desafios e possibilidades de Planos Municipais de Mata Atlântica (PMMA), apresentando um panorama acerca do estado da arte referente à legislação, com aproximações e discussões relacionadas a planos elaborados e em fase de implementação em âmbito nacional e estadual. O procedimento metodológico adotado foi através de levantamento das bibliografias pertinentes a Planos Municipais de Mata Atlântica, obtidas em plataformas da Web, sites governamentais e não governamentais, periódicos e material impresso, focando na ação e estratégias abordadas pelos documentos aferidos. Por meio de um recorte de algumas propostas dos PMMA, foi observado que os municípios que se organizam em consórcios e convênios de caráter regional, tendem a vislumbrar melhores perspectivas de planejamento ambiental que vão além dos limites sociopolíticos. Embora a maior parte dos PMMA atenda ao mínimo de exigências da legislação para sua composição, poucos incluem medidas como a conservação pelo uso, ou alternativas de pagamento pelos serviços ambientais. Entre as ações de conservação integrativas propostas, é possível destacar a inovação da conservação pelo uso com base em Sistemas Agroflorestais e Extrativismo Sustentável da Flora Nativa. Tais aspectos têm sido viabilizados no Estado do Rio Grande do Sul. Todavia, em muitos estados brasileiros esta realidade ainda se encontra no âmbito dos debates conceituais relacionados à conservação e preservação ambiental.
Background pessoal do professor
Authors: Pereira Junior Errol Fernando Zepka , Paes Ketlle Duarte , Fehlberg Ribeiro Nathalia
Published: November 2020

Este trabalho tem como objetivo analisar, mapear e revisar as publicações científicas à nível mundial sobre background do professor. Para isto, foi realizado um estudo bibliométrico e sistemático com análise conteúdo dos artigos localizados nas bases de dados Scopus e Web of Science. A análise de conteúdo fornece uma visão aprofundada sobre cada um dos artigos. Dos artigos trabalhados, destaca-se o crescimento temporal no interesse das publicações e indicadores dos países, instituições, autores e periódicos mais produtivos. Os achados da presente pesquisa podem indicar um panorama geral do que vem sendo publicado mundialmente acerca da temática sobre background do professor.
SIGNIFICANCE OF THE HYPOTHERMIA LEVEL FOR NEUROPHYSIOLOGICAL REACTIONS OF HUMAN ORGANISM TO EXPERIMENTAL WHOLE-BODY COOLING
Authors:   N. Laverov Federal Center for Integrated Arctic Research, Russian Academy of Sciences, Arkhangelsk, Demin D.B.
Published: November 2020

Effects of hypothermia on the character of changes in central hemodynamics, heart rate variability (HRV) and EEG were studied during an experimental whole-body cooling of 30 healthy male subjects at the age of 18–20 years. The subjects were divided into 2 equal groups by the median body temperature in the total sample (34.1 °С) during cooling. The experiment consisted of 3 steps: rest at +20 °С, 10-min exposure to -20 °С in a hypothermal chamber and rewarming at +20 °С. The parameters registered at each step included EEG, blood pressure (BP), heart rate (HR) and temperature in the external auditory meatus. In the cooling chamber, body temperature lowered reliably by 1.4–3.1 °С on the average. In both groups hypothermia reduced the index of regulatory systems strain, increased total HRV power and BP, and decreased HR. During rewarming all these parameters tended to return to baseline values. Subjects with a more distinct hypothermia (33.1 °С) displayed a weakened baroreflex reaction (slight HR reduction) accompanied by a stronger vascular reaction (significant BP rise). High baroreflex stability in the subjects with low-level hypothermia (35 °С) was evidenced by a significant HR decrease in response to the BP rise. Changes in the EEG amplitude and frequency patterns during cooling declared themselves by enhancement of the subcortex regulatory activity (reliable rise in the theta-activity). Also, the alpha-activity was increased in the subjects with high-level hypothermia and decreased in 73 % of the subjects with a low-level hypothermia which points to desynchronization of the main rhythm.
A critical transcription factor NF-κB as a cancer therapeutic target and its inhibitors as cancer treatment options
Authors: Suhail Mohd , Tarique Mohammad , Muhammad Naoshad , Naz Huma , Hafeez Abdul , Zughaibi Torki A. , Kamal Mohammad Amjad , Rehan Mohd
Published: November 2020

:

Nuclear Factor-κappa B (NF-κB) is a family of critical transcription factors of inflammatory pathway and plays
an imperative role in the progression of various cancers such as breast, lung, liver, pancreatic, prostate and multiple types of
lymphoma. NF-κB develops an inherent relationship between inflammation and cancer. It is a crucial factor which controls
the ability of malignant and pre-neoplastic cells to prevent programmed cell death-based tumor-surveillance channels. Due
to its high significance in the onset and progression of various cancers, it has become an excellent target for cancer therapy.
The emerging targeted therapies provide a lot of hope, whereby a single protein or generally the target enzyme is completely
blocked. Several natural compounds have shown anticancer and anti-inflammatory activities by inhibiting NF-κB pathway
in various cancer types. About 750 natural and synthetic inhibitors of the NF-κB have been reported. These inhibitors include microbial and viral proteins, small RNA/DNA, antioxidants, small molecules, peptides, and engineered constitutively
active polypeptides, all of which may inhibit canonical and alternative NF-κB pathways. Thus, blocking or targeting the NFκB-signaling pathways by using natural and synthetic compounds could be a potential mechanism to cure the NF-κB induced tumors.
Naturally Inspired Pyrimidines Analogues for Alzheimer’s Disease
Authors: Singh Shivani , Dhanawat Meenakshi , Gupta Sumeet , Kumar Deepak , Kakkar Saloni , Nair Anroop , Verma Inderjeet , Sharma Prerna
Published: November 2020

:

Alzheimer’s disease (AD) is a multifarious and developing neurodegenerative disorder. The treatment of AD is still a challenge and availability of drug therapy on the basis of symptoms is not up to the mark. In the context of existence, which is getting worse for the human brain, it is necessary to take care of all critical measures. The disease is caused due to multidirectional pathology of the body, which demands the multi-target-directed ligand (MTDL) approach. This gives hope for new drugs for AD, summarized here in with the pyrimidine based natural product inspired molecule as a lead. The review is sufficient in providing a list of chemical ingredients of the plant to cure AD and screen them against various potential targets of AD. The synthesis of a highly functionalized scaffold in one step in a single pot without isolating the intermediate is a challenging task. In few examples, we have highlighted the importance of this kind of reaction, generally known as multi-component reaction. Multi-component is a widely accepted technique by the drug discovery people due to its high atom economy. It reduces multi-step process to a one-step process, therefore the compounds library can be made in minimum time and cost. This review has highlighted the importance of multicomponent reactions by giving the example of active scaffolds of pyrimidine/fused pyrimidines. This would bring importance to the fast as well as smart synthesis of bio-relevant molecules.
Implementation of soft skills on Automotive Engineering practicum of state vocational high schools in West Lombok Regency
Authors: Firmansyah Aprian , Soeharto Soeharto
Published: November 2020

This study aims to determine the implementation of soft skills in automotive workshop expertise program majoring in automotive light vehicle engineering of Vocational High Schools in District of West Lombok in terms of tow components which include: (1) the condition of students and learning planning in practicum; (2) how much how much the level of soft skills in automotive engineering practicum of Vocational High School students. This study includes a type of quantitative research with a descriptive approach.The study population was all State Vocational Schools majoring in automotive light vehicle engineering in West Lombok. The research sample consisted of four vocational high schools with 84 students of class XII and four teachers determined using purposive sampling techniques. The results showed that: (1) the condition of students in implementation of soft skills included in the good category with a percentage of achievement of 46.43% and the condition of learning planning included in the good category with a percentage of achievement of 50% ;(2) the results of how much level of soft skills are in the good category with a percentage of achievement of 49%.
Leveraging Internet Search Data to Improve the Prediction and Prevention of Noncommunicable Diseases: Retrospective Observational Study
Authors: Xu Chenjie , Cao Zhi , Yang Hongxi , Gao Ying , Sun Li , Hou Yabing , Cao Xinxi , Jia Peng , Wang Yaogang
Published: November 2020

Background

As human society enters an era of vast and easily accessible social media, a growing number of people are exploiting the internet to search and exchange medical information. Because internet search data could reflect population interest in particular health topics, they provide a new way of understanding health concerns regarding noncommunicable diseases (NCDs) and the role they play in their prevention.

Objective

We aimed to explore the association of internet search data for NCDs with published disease incidence and mortality rates in the United States and to grasp the health concerns toward NCDs.

Methods

We tracked NCDs by examining the correlations among the incidence rates, mortality rates, and internet searches in the United States from 2004 to 2017, and we established forecast models based on the relationship between the disease rates and internet searches.

Results

Incidence and mortality rates of 29 diseases in the United States were statistically significantly correlated with the relative search volumes (RSVs) of their search terms (P<.05). From the perspective of the goodness of fit of the multiple regression prediction models, the results were closest to 1 for diabetes mellitus, stroke, atrial fibrillation and flutter, Hodgkin lymphoma, and testicular cancer; the coefficients of determination of their linear regression models for predicting incidence were 80%, 88%, 96%, 80%, and 78%, respectively. Meanwhile, the coefficient of determination of their linear regression models for predicting mortality was 82%, 62%, 94%, 78%, and 62%, respectively.

Conclusions

An advanced understanding of search behaviors could augment traditional epidemiologic surveillance and could be used as a reference to aid in disease prediction and prevention.
'L'Italia verrà a Trieste'. "Ritorneranno": storia romantica dell'irredentismo triestino
Authors: Del Tedesco Enza
Published: November 2020

Abstract
Ceramide turnover (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
Authors: Futerman Anthony H.
Published: November 2020

Ceramides are a family of sphingophospholipids synthesized in the endoplasmic reticulum, which mediate cell stress responses, including apoptosis, autophagy and senescence, Serine palmitoyltransferase generates 3-ketosphinganine, which is reduced to dihydrosphingosine (dihydrosphingosine). N-Acylation allows the formation of dihydroceramides, which are subsequently reduced to form ceramides. Once synthesized, ceramides are trafficked from the ER to the Golgi bound to the ceramide transfer protein, CERT (COL4A3BP, Q9Y5P4). Ceramide can be metabolized via multiple routes, ensuring tight regulation of its cellular levels. Addition of phosphocholine generates sphingomyelin while carbohydrate is added to form glucosyl- or galactosylceramides. Ceramidase re-forms sphingosine or sphinganine from ceramide or dihydroceramide. Phosphorylation of ceramide generates ceramide phosphate. The determination of accurate kinetic parameters for many of the enzymes in the sphingolipid metabolic pathway is complicated by the lipophilic nature of the substrates.
Capacidade funcional de idosos com diagnóstico indicativo de alzheimer
Authors: Ferretti Fátima , Gauer Ana Paula Maihack , Tomazeli Eli Fernanda , De Sá Clodoaldo Antonio , Corralo Vanessa da Silva
Published: November 2020

Resumo: Objetivos: Avaliar a capacidade funcional de idosos com diagnóstico indicativo de Alzheimer e relacionar o nível de independência funcional, com anos de sintomas em função do sexo e da faixa etária. Métodos: Participaram desse estudo 50 idosos com diagnóstico indicativo de Alzheimer, sendo 36 do sexo feminino e 14 do sexo masculino (idade 80,0±7,21 e 77,35±8,89 anos, respectivamente). Os instrumentos de coleta utilizados foram o Mini Exame do Estado Mental (MEEM), protocolo de Barthel, Lawton e Time Up and Go (TUG). Resultados: Os resultados do MEEM evidenciaram um maior comprometimento cognitivo para o grupo com mais de nove anos de sintomas em relação ao grupo com até quatro anos (p=0,013). Quanto à avaliação funcional a partir do protocolo de Barthel e avaliação da mobilidade (TUG), não foram evidenciadas diferenças (p>0,05) entre os grupos etários analisados. Com relação à análise da capacidade funcional, avaliada pelo protocolo de Lawton, demonstrou-se que os grupos com 5 a 8 anos e com mais de 9 anos de sintomas, apresentaram um comprometimento funcional significativamente maior (p<0,05) que o grupo com até 4 anos de sintomas.O tempo de sintomas correlacionou-se positivamente (p<0,05) com a capacidade cognitiva e funcional. Conclusão: Com base nos resultados, pode-se inferir que o nível de independência funcional de idosos com diagnóstico indicativo de DA está relacionado com a progressão da doença, considerando os anos de sintomas.
Fisioterapia pélvica na prevenção das disfunções pélvicas
Authors: Rocha Maria Angélica , Carneiro Nunes Erica Feio , Latorre Gustavo Fernando Sutter
Published: November 2020

Introdução: A fisioterapia pélvica vem sendo apontada como potencial na prevenção das lesões obstétricas do assoalho pélvico, mas ainda não está claro se esta terapêutica poderia, de fato, reduzir os riscos deste tipo de lesão. Objetivo: verificar a eficácia da fisioterapia pélvica durante o pré-natal, parto e puerpério como prevenção de disfunções pélvicas. Metodologia: Revisão sistemática da literatura, na qual buscaram-se por artigos concernentes ao treinamento dos músculos do assoalho pélvico (TMAP) no pré-natal, parto e no puerpério. As buscas foram efetuadas no período de janeiro a junho de 2017, nas bases de dados PubMed, LILACS, PEDro, SciELO. Utilizou-se as palavras-chave: fisioterapia pélvica, gravidez, parto vaginal e puerpério e suas variantes em inglês. Resultados: A partir da estratégia de busca, 73 estudos foram encontrados empregando os descritores. Destes, foram excluídos 17 por serem duplicados, ficando 56 artigos para seleção pelo título. Excluiu-se 9 artigos após seleção pelo título, restando 47 artigos para serem analisados pelo resumo, deste foram selecionados 17 artigos, e finalmente, a leitura na íntegra elegeu 11 artigos para análise. Conclusão: A demanda pelo parto normal tem crescido exponencialmente e a escassez de estudos relacionados com a assistência à gestante sob ponto de vista fisioterapêutico nos mostra um campo amplo a ser desbravado com melhores padrões de pesquisa e protocolos validados na assistência à gestante, parturiente e puérpera especialmente no que se refere ao treinamento dos músculos do assoalho pélvico.
Palavras-chave:Fisioterapia. Parto vaginal. Assoalho pélvico
Comparação das técnicas de facilitação neuromuscular proprioceptiva na função respiratória de indivíduos com doença de Parkinson
Authors: Dos Santos Jennifer Heltz , Dos Santos Reni Volmir
Published: November 2020

Introdução: A Doença de Parkinson (DP) é uma patologia crônica e neurodegenerativa, caracterizada pelo tremor, bradicinesia, rigidez e instabilidade postural, através da progressão da doença, de caráter multifatorial, o sistema respiratório apresenta disfunções. Objetivo: Comparar o efeito imediato da facilitação neuromuscular proprioceptiva (FNP) respiratória e de escápula e pelve na função respiratória de indivíduos com doença de Parkinson. Materiais e métodos: Ensaio clínico randomizado, simples cego, realizado na Clínica Escola de Fisioterapia da Universidade Luterana do Brasil-ULBRA/Canoas, com uma amostra de 12 indivíduos, com diagnóstico de Doença de Parkinson. Os mesmos assinaram o Termo de Consentimento Livre e Esclarecido e foram avaliados através do Miniexame do Estado Mental (MEEM), da escala de Hoehn e Yahr Modificada, capacidade inspiratória, pico de fluxo expiratório e pressões inspiratória e expiratória máximas. Após, foram alocados por sorteio em Grupo A (FNP respiratório) e Grupo B (FNP de escápula e pelve). Resultados: O FNP respiratório se mostrou eficaz nos parâmetros respiratórios avaliados, sendo estatisticamente significativo (p<0,05), assim como o FNP de escápula e pelve para a capacidade inspiratória (p=0,041). Já a comparação entre os dois grupos mostrou que o FNP respiratório foi mais eficaz, apesar de não apresentar significância estatística. Conclusão: As duas técnicas foram eficazes no aumento da capacidade inspiratória, porém a técnica de FNP respiratória mostrou-se efetiva também no aumento do pico de fluxo expiratório e pressões inspiratória e expiratória máximas.
Avaliação do pico de fluxo expiratório em indivíduos pós acidente vascular cerebral - AVC
Authors: Gomes Lucas Ewerton Rodrigues , Albuquerque Stélane Carneiro , Da Silva Abigail Ada Barbosa , Martins Ilamara Raniere Targino , Da Silva Junior Roque Ribeiro , Da Silva Magda Lorena Nogueira
Published: November 2020

Introdução: O Acidente Vascular Cerebral (AVC) é uma afecção neurológica caracterizada por déficit de oxigênio e nutrientes ao cérebro. Indivíduos pós AVC tendem a ter fraqueza da musculatura respiratória, repercutindo em diminuição das capacidades e volumes pulmonares. Objetivo: avaliar o Pico de Fluxo Expiratório (PFE) desses indivíduos. Metodologia: trata-se de um estudo transversal, observacional, descritivo e quantitativo, que mensurou o PFE de moradores da cidade de Beberibe (CE) com diagnóstico clínico de AVC. A população abrangeu indivíduos pós AVC, moradores da cidade de Beberibe (CE). A amostra foi constituída por dez participantes. Participaram do estudo, pessoas com diagnóstico confirmado de AVC, com pelo menos seis meses de acometimento, cognitivo preservado, independente do sexo, idade igual e/ou acima de 55 anos, ausência de afecções respiratórias associadas, ou neurológicas que comprometessem o cognitivo, não fumantes ativos. Foram excluídos indivíduos que faziam uso de medicamentos com ação respiratória, restritos ao leito, e que atualmente participavam de algum tratamento fisioterapêutico. A mensuração do PFE foi feita através do Peak Flow Meters. Os dados obtidos foram analisados por meio de estatística descritiva, “teste t de Student” e regressão linear e foram tabulados em tabelas. Resultados: percebe-se um predomínio de AVC Isquêmico, homogeneidade de gênero, hipertensão arterial sistêmica como comorbidade mais prevalente; os valores de PFE da amostra feminina e masculina demonstraram-se estatisticamente significativo (p< 0,002) quando comparados aos valores de referência. Conclusão: nessa amostra de indivíduos com AVC crônico, houve redução estatisticamente significativa do PFE.
Formar para la mediación pedagógica en el museo de ciencias: una experiencia en la Universidad Nacional de La Plata, Argentina
Authors: Pedersoli Constanza , Court Maria Florencia , Docters María Luján
Published: November 2020

En este trabajo se presenta una experiencia de formación de mediadores en popularización de las ciencias desarrollada, entre 2012 y 2017, en el museo de ciencias de Mundo Nuevo, Programa de Popularización de las Ciencias de la Universidad Nacional de La Plata, provincia de Buenos Aires en Argentina. Se comparten aquí los supuestos que organizaron aquella experiencia, las características del contexto institucional en que tuvo lugar el proceso de formación, los contenidos, los dispositivos desarrollados y algunas de las reflexiones surgidas a partir de su implementación.
CosmoExplainers. Explicando la ciencia en CosmoCaixa, el Museo de la Ciencia de la Fundación “la Caixa”, Barcelona (España)
Authors: Smandia Cristina
Published: November 2020

¿Cómo podemos vincular a los adolescentes a nuestros museos? El programa Explainer, insignia del Exploratorium de San Francisco, ha conseguido motivar a los más jóvenes al museo implicándolos en la mediación de sus contenidos. Desde 2013 en CosmoCaixa, el museo de la Ciencia de la Fundación “la Caixa”, hemos implementado el programa. En este artículo explicamos nuestra experiencia, sus características y diferencias con el programa de San Francisco, así como las dificultades que nos hemos encontrado, el estado actual del programa y su proyección de futuro.
Matemáticas, espacios públicos e integración vecinal. El caso de Cuernavaca (México)
Authors: Barahona Igor , Lopez de Medrano Lucia , Martínez-Moreno Bárbara , Limon Beatriz
Published: November 2020

El objetivo principal es investigar el impacto que tienen un conjunto de actividades de comunicación de las matemáticas realizadas en espacios públicos de colonias con marginación alta, en el fortalecimiento del tejido social y mejoramiento de la percepción de seguridad. Una plaza de la colonia Chamilpa en Cuernavaca, México es tomada como caso de estudio. Esta colonia se encuentra entre las de mayor marginación de la ciudad. Los resultados proporcionan evidencia empírica para soportar que la comunicación de las matemáticas en espacios públicos aumenta la percepción de seguridad y mejora la cohesión social.
A IGREJA CRISTÃ MARANATA E A PECULIAR MESCLA RELIGIÃO-CIÊNCIA NA ANÁLISE DA PANDEMIA
Authors: Cruz Eduardo Rodrigues da
Published: November 2020

Anúncios publicitários da Igreja Cristã Maranata publicados na revista Veja, na época de maior disseminação da pandemia, suscitam o interesse em uma forma específica de apresentar o diálogo entre religião e ciência. Pastores e diáconos que também possuem formação em ciência engajam informações da física, da biologia, da genética etc. no serviço da doutrina tradicional dessa igreja, de corte apocalíptico. Para dar conta da mescla daí resultante, três abordagens distintas e que se completam são trazidas para a análise: a tipologia quádrupla de Ian Barbour sobre as relações entre ciência e religião, a análise de legitimação da religião pela ciência de James Lewis e o estudo do sincretismo de religião e ciência que Jesper Petersen apresenta. Conclui-se que a pandemia da Covid-19 serviu de pretexto para a divulgação da doutrina da Igreja Maranata, que trouxe uma mescla entre ciência e religião passível de análise pelas abordagens mencionadas.
“QUEM MERECE VIVER E QUEM MERECE MORRER”: DILEMAS ÉTICOS EM TEMPOS DE PANDEMIA DA COVID-19
Authors: Westphal Euler Renato
Published: November 2020

A medicina contemporânea, que é determinada pela tecnologia, negligenciou a possibilidade da morte dos pacientes. Dessa forma, a morte é protelada por meio de terapias invasivas, que não permitem a pessoa em estado terminal morrer. A busca frenética da ciência médica por tecnologias avançadas foi interrompida por um microrganismo, o SARS-CoV-2. Percebeu-se na pandemia que uma medicina voltada para a tecnologia é pouco eficaz se questões como saúde pública, higiene e meio ambiente não forem sufi cientemente contempladas. No contexto da Covid-19, dilemas éticos se tornam especialmente relevantes diante do avanço da doença, da escassez e do esgotamento dos recursos médicos. Em meio ao desenvolvimento da pandemia, no processo de triagem de pacientes da Covid-19, a pergunta “quem merece viver e quem merece morrer?” torna-se dramaticamente atual. Este artigo tem como objetivo destacar aspectos fundamentais entre a esperança de uma medicina moldada pelo poder tecnológico e a realidade dos conflitos médicos em tempos de pandemia. A partir da teologia luterana, busca-se entender o sentido e a esperança para além da morte, prometida e frustrada pela escatologia tecnológica.