bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient-reported symptoms and impacts of locally advanced or metastatic urothelial cancer (la/mUC) after chemotherapy followed by a PD-1/PD-L1 checkpoint inhibitor (CPI).
Authors: Shah Manasee , Devine Jacob , Wang Sam , Hepp Zsolt , Shah Sonali
Published: March 2019

380

Background: Published literature on la/mUC patient burden is limited. Patient interviews can help better characterize the symptoms and impacts associated with disease and treatment management. Methods: Patients (pts) aged ≥18 yr with non-resected la/mUC treated with chemotherapy followed by a CPI were recruited. Semi-structured 60 min telephone interviews were conducted; transcripts were analyzed. In a follow-up survey, pts rated the bothersomeness of their symptoms and impacts on quality of life (QoL) on a 0–10 scale (0, not at all bothersome; 10 most bothersome). Results: Twenty-four pts (median age, 55 yrs [range 33–70]) were interviewed; most were female (67%), < 65 yrs (79%) with stage IV mUC (63%). Due to recruitment limitations, this study was conducted in a unique non-resected advanced UC population who were generally younger and included more females than the broader la/mUC population. These pts experienced a range of signs/symptoms and overlap was reported between ongoing disease- and treatment-related symptoms. Fatigue, sexual dysfunction, and sleep disturbances were attributed to both disease and treatment; nausea/vomiting and hair loss were attributed to treatment alone. Common ongoing symptoms were fatigue (92%), hematuria (88%), pain (75%), and urinary symptoms (71%); most salient symptoms (defined as mean bothersome rating ≥5 in ≥50% of pts) were loss of hair, weight, and appetite, as well as fatigue, hematuria, pain, urinary symptoms, and nausea/vomiting. The most salient impacts were those on emotional functioning and family relationships. Most pts did not report significant difficulty with basic activities of daily living (ADLs). Some pts reported challenges with instrumental ADLs (eg, shopping, cooking); most pts reported ncreased reliance on friends and relatives for assistance. Conclusions: Patients with la/mUC treated with chemotherapy and CPI report that symptoms and impacts have profound effects on health-related QoL. The inclusion of instruments within a clinical trial that accurately capture pts’ experiences will enhance understanding of the disease course and the benefits of treatment.
Activity of RX-3117, an oral antimetabolite nucleoside, in subjects with advanced urothelial cancer: Preliminary results of a phase IIa study.
Authors: Salgia Nicholas , Pal Sumanta K. , Chung Vincent , Tagawa Scott T. , Picus Joel , Babiker Hani M. , Gupta Sumati , Wadlow Raymond Couric , Poore Julie , Peterson Christine , Benaim Ely
Published: March 2019

455

Background: RX-3117 is an oral small molecule antimetabolite that is activated by uridine cytidine kinase 2 (UCK2) which is predominantly expressed in cancer cells. RX-3117 has shown efficacy in xenograft models of gemcitabine resistant pancreatic, bladder and colorectal cancer. Preliminary data from an analysis of a Phase 2a clinical study of RX3117 in advanced urothelial cancer is described. Methods: In the Phase 2a study designed to evaluate safety, tolerability and efficacy, subjects were treated with oral RX-3117 (700 mg) once-daily for 5 consecutive days on and 2 days off for 3 of 4 weeks or all 4 weeks in a 28-day cycle. Eligible subjects (aged ≥ 18 years) had relapsed/refractory metastatic urothelial cancer, ECOG PS of 0 to 1, normal organ function (hepatic, renal and hematology) with no limit on the number of prior therapies. The primary Phase 2a endpoints are progression free survival (PFS) and/or objective clinical response with secondary endpoints of safety, TTP, DOR and ORR. Results: As of October 5, 2018; 33 subjects were treated (23 males and 10 females, median age 67.5 years); 29 subjects were evaluable having completed more than 1 cycle of therapy or discontinued due to a related adverse event. Twenty subjects had received 3 or more prior therapies; 30 received gemcitabine/cisplatin and 25 received a checkpoint inhibitor. The most common related adverse events were anemia (G1-2%, G2-3%, G3-3%), fatigue (G1-6%, G2-3%), neutropenia (G2-2%, G3-5%, G4-2%), diarrhea (G1-4%, G2-2%), and thrombocytopenia (G2-2%, G3-3%, G4-1%). One subject had a complete response after 4 cycles of therapy and continues therapy beyond 10 cycles; 5 subjects had PFS ranging from 133 to 315 days. Conclusions: RX-3117 appears to be safe and well-tolerated in chemotherapy and immunotherapy refractory advanced urothelial cancer with acceptable toxicities. Preliminary results show anti-tumor activity in heavily pre-treated patients. Clinical trial information: NCT02030067.
Malignant pheochromocytoma: A comprehensive genomic profiling study.
Authors: Bratslavsky Gennady , Necchi Andrea , Shapiro Oleg , Jacob Joseph , Gay Laurie M. , Alexander Brian Michael , Elvin Julia Andrea , Vergilio Jo-Anne , Killian Jonathan Keith , Nho Nhu Thi , Ramkissoon Shakti , Severson Eric Allan , Hemmerich Amanda , Ali Siraj Mahamed , Chung Jon , Reddy Venkataprasanth P. , Miller Vincent A. , Schrock Alexa Betzig , Liu Nick , Ross Jeffrey S.
Published: March 2019

508

Background: Malignant pheochromocytomas (MP) are a rare form of endocrine malignancy which can occur in familial and sporadic clinical settings. We performed comprehensive genomic profiling (CGP) to characterize the genomic alterations (GA) in MP and to enable the search for potential therapy targets. Methods: From a series of 181,782 consecutive clinical cases, 43 cases of clinically advanced MP underwent CGP using a hybrid-capture based commercial assay to evaluate all classes of GA. Tumor mutational burden (TMB) was determined on 1.1 Mbp of sequenced DNA and reported as mutations/Mb and microsatellite instability (MSI) was determined on 114 loci. IHC for PD-L1 expression was performed on a subset of patients (DAKO 22C3 antibody). Results: All patients had clinically advanced recurrent and/or metastatic disease. There were 33 (77%) of MP known to have originated in the adrenal gland and 10 (23%) of the MP were sequenced from metastatic site. The primary tumor was used for sequencing in 13 (30%) of the MP cases and a non-primary tumor metastatic site (liver, lung, bone, soft tissue, lymph node, kidney, peritoneal cavity, and chest wall) in 30 (70%) of the MP cases. There were 2.3 GA/tumor. The most frequent un-targetable GA were ATRX (26%), TP53 (21%), SDHB (11%), CTNNB1 (7%), VHL (7%), and CDKN2A/2B, PIK3R2, NOTCH2 and MEN1 (all 5%). The most frequent potentially targetable GA included RET (9%), NF1 (9%) and FGFR1 (5%). PBRM1 GA were found in 2% of MAP. Germline mutations in known cancer predisposition genes were predicted in 7 (16%) of cases involving SDHB (4 cases) and BRCA1, MEN1, and MSH2 (1 case each). The mean TMB was 2.95 mutations/Mb, the median TMB was 2.4 mutations/Mb. 0 (0%) of 33 MP evaluated for MSI had a MSI-High status. Conclusions: MP represent a rare form of endocrine cancer that feature a variety of genomic alterations. Although the GA/tumor is relatively low for MP, CGP can reveal important potential targets for therapy in the metastatic setting including RET, NF1 and FGFR1. MAP do not reveal strong potential for immunotherapy with low TMB, absence of MSI-High status and low (2%) PBRM1 mutation frequencies. Based on this data, further study of CGP as a method of developing precision therapies for MP appears warranted.
Predicting vital retroperitoneal residual tumors of metastatic testicular tumor patients after chemotherapy using radiomics.
Authors: Nestler Tim , Baeßler Bettina , Pinto dos Santos Daniel , Pfister David J. K. P. , Maintz David , Heidenreich Axel
Published: March 2019

527

Background: About 50% of patients undergoing post-chemotherapy retroperitoneal lymph node dissection (pcRPLND) are overtreated due to missing markers or valid prediction scores prior surgery. The potential of radiomics and machine learning applied on computed tomography (CT) imaging to predict the presence of viable tumor or teratoma in retroperitoneal lymph node metastases from germ cell tumor (GCT) patients prior to pcRPLND has not been explored. Therefore, we applied radiomics and machine learning to CT images of GCT patients prior to pcRPLND. Methods: Metastasized GCT patients who were treated with chemotherapy and received a contrast-enhanced CT prior to pcRPLND possessing complete clinical data were included in the study. Only lymph nodes which were identified in the CT images and correlated with the pathological findings (benign: necrosis / fibrosis vs. viable: viable tumor/ teratoma) were included. Lymph nodes identified in the CT images, were semiautomatically segmented and 93 radiographic features were analyzed. A linear support vector machine (SVM) algorithm was applied to analyze reproducible radiomics features. Additionally, a continuous reduction of the features analyzed was performed using Random Forest algorithms, as well as consecutive correlation and receiver operating curve analyzes. Results: Forty-two patients fulfilled the inclusion criteria and were included in the study. Total in these patients 96 lymph nodes were segmented on CT. Histologically, 41 lymph nodes were classified as viable tumors and 55 as benign. To train the SVM, 67 lymph nodes were randomly selected. Of the 93 radiomic features analyzed, 51 features were reproducible. Applying the trained algorithm to the remaining 29 lymph nodes resulted in a classification accuracy of 82% with a diagnostic sensitivity of 81% and a specificity of 83%. After multistep feature reduction, the three most important predictors for viable tumor achieved a sensitivity of 66% and a specificity of 78% when combined in a multivariate model. Conclusions: The applied radiomics model, solely based on CT images achieved a good sensitivity and specificity in predicting viable metastases.
Efficacy and safety of nivolumab in patients with non-clear cell renal cell carcinoma (RCC): Results from the phase IIIb/IV CheckMate 374 study.
Authors: Vogelzang Nicholas J. , McFarlane Joshua Jemison , Kochenderfer Mark D. , Molina Ana M. , Arrowsmith Edward , Bauer Todd Michael , Hauke Ralph J. , Jain Rohit , Somer Bradley G. , Lam Elaine Tat , Doshi Gurjyot K. , Gunuganti Vijay , Zhang Joshua , Zhao Huanyu , Johansen Jennifer , Tykodi Scott S.
Published: March 2019

562

Background: Initial safety results from the phase 3b/4 CheckMate 374 study showed that flat-dose nivolumab (NIVO) at 240 mg every 2 wk (Q2W) had a consistent safety profile across patients (pts) with clear cell and non-clear cell advanced RCC. We report updated safety and first disclosure of efficacy for pts with non-clear cell RCC (nccRCC) in CheckMate 374. Methods: Eligible pts in this cohort were adults with advanced or metastatic nccRCC who received 0–3 prior systemic therapies. Pts received NIVO 240 mg IV Q2W for ≤24 mo or until confirmed progression, unacceptable toxicity, or withdrawal of consent. Pts who benefited after 24 mo continued treatment according to the standard of care. The primary endpoint was incidence of high-grade immune-mediated adverse events (IMAEs). Exploratory endpoints included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and duration of response (DOR). Results: In CheckMate 374, 44 pts had nccRCC. Histological subtypes included papillary (n = 24), chromophobe (n = 7), unclassified (n = 8), and other (n = 5). Most pts with nccRCC (66%) were treatment-naïve. After a median follow-up of 11.1 mo, median OS was 16.3 mo (95% confidence interval [CI] 9.2–not estimable [NE]). OS was similar regardless of baseline PD-L1 expression. ORR was 13.6% (95% CI 5.2–27.4). One pt had complete response (chromophobe histology) and 5 pts had partial response (2 pts with papillary and 1 pt each with chromophobe, collecting duct, and unclassified histology). Median DOR was 10.2 mo (95% CI 5.6–NE). Median PFS was 2.2 mo (95% CI 1.8–5.4). The 1-year PFS rate was 14% (95% CI 5–27). No new safety concerns were identified. No treatment-related grade 5 AEs or grade 3–4 IMAEs were reported. Conclusions: Clinically meaningful antitumor activity was observed in the first prospective study of NIVO monotherapy in nccRCC. Responses were observed in several histological subtypes. The safety profile of flat-dose NIVO at 240 IV Q2W is consistent with the initial outcomes reported from this study and across the NIVO program. Clinical trial information: NCT02596035.
The association of anxiety and depression with mortality risk among patients with clear cell renal cell carcinoma undergoing nephrectomy.
Authors: Packiam Vignesh T. , Tsivian Matvey , Tyson Mark D. , Lohse Christine M. , Cheville John C. , Boorjian Stephen A. , Leibovich Bradley C. , Thompson Robert Houston
Published: March 2019

617

Background: Anxiety and depression are psychosocial factors which have been demonstrated to have mixed interactions with mortality across various malignancies. While these variables have been associated with poor overall survival for patients with metastatic RCC, the influence on outcomes for localized RCC has been poorly studied. We evaluated the association of anxiety or depression with survival in patients with surgically treated localized clear cell RCC (ccRCC). Methods: We performed retrospective review of our institutional nephrectomy registry to identify 1,990 patients who underwent radical or partial nephrectomy for unilateral, sporadic, non-metastatic ccRCC between 1995- 2011. Baseline anxiety and depression were identified using ICD-9 codes. Associations of anxiety or depression with outcomes of interest were evaluated using Cox proportional hazards models. Two propensity score (PS) techniques were used: adjusting for PS quintile and re-weighting by stabilized inverse probability weights. Results: A total of 197 (10%) patients had diagnoses of anxiety or depression (57 had anxiety alone, 107 had depression alone, and 33 had both anxiety and depression). Median follow-up among survivors was 10.0 (IQR 7.3-13.6) years, during which time 864 died, including 363 from RCC. Patients with anxiety or depression were younger (mean age 59 vs 62 years, p < 0.001) and had more recent operations (75% vs 47% in 2005-2011, p < 0.001) compared to those with neither diagnosis. After PS adjustment, all clinical and pathologic features were well balanced between groups. After PS adjustment, there were no significant differences in time to local ipsilateral recurrence, distant metastases, and death from RCC between groups. We did note a trend to poorer overall survival in patients with anxiety or depression (HR 1.29, 95%CI = 0.98-1.69, p = 0.065). Conclusions: Our results suggest that neither anxiety nor depression is significantly associated with oncologic outcomes among patients with localized surgically treated ccRCC. The trend toward worse overall survival among patients with anxiety or depression warrants further investigation.
Phase I/II dose-escalation trial of fractionated dose 177Lu-J591 plus 177Lu-PSMA-617 for metastatic castration-resistant prostate cancer (mCRPC).
Authors: Tagawa Scott T. , Niaz Muhammad Junaid , Osborne Joseph , Vallabhajosula Shankar , Beltran Himisha , Harshman Lauren Christine , Nanus David M. , Molina Ana M. , Faltas Bishoy Morris , Hackett Amy , Gracey Lauren , Sreekumar Jyothi , Babich John , Ballman Karla V. , Bander Neil Harrison
Published: March 2019

TPS339

Background: PC is a radiosensitive disease. PSMA is selectively overexpressed in advanced PC with upregulation by androgen receptor (AR) pathway dysregulation; limited expression exists in other organs. Prior studies of beta-emitting radiolabeled anti-PSMA antibody J591 demonstrated accurate targeting, efficacy with dose-response effect, and safety with predictable dose-limiting myelosuppression. Recent prospective trials have shown efficacy and safety of 177Lu-PSMA-617 in mCRPC. Studies demonstrate different binding sites of J591 and PSMA-617 and co-administration leads to non-competitive additive binding and delivery of payloads to PSMA+ cells. As the pharmacokinetics and biodistribution of the 2 agents is mostly non-overlapping (other than tumor) and given our prior dose-response data, we hypothesize that delivery of the combination will yield higher tumor delivery with less off-target toxicity (i.e. better responses without increased toxicity). Methods: Men with progressive mCRPC following at least 1 potent AR-targeted agent (e.g. abi/enza) and docetaxel (or unfit/refuse chemo) with metastatic disease on CT/MRI or bone scan without limit of # prior therapies (excluding bone-targeted beta-emitting radioisotopes) provided adequate organ function will be enrolled. Pre-treatment 88Ga-PSMA-11 will be performed, but results are not used for eligibility. Treatment includes fractionated 177Lu-J591 at a fixed moderate dose with escalating doses of 177Lu-PSMA-617 (7.4 – 18.5 GBq per cycle, fractionated D1 and D15) in a 3+3 dose-escalation study. Dose-limiting toxicity (DLT) is defined as attributable grade > 3 heme toxicity or grade > 2 non-heme toxicity. Following determination of recommended phase 2 dose (RP2D), the phase 2 portion will enroll in a 2-stage design. Primary endpoints: DLT and RP2D (ph 1) and PSA decline proportion (ph 2). Secondary endpoints include toxicity, radiographic response, PFS, rPFS, OS, CTC count changes. Correlatives include baseline/follow up PSMA imaging, whole body distribution of 177Lu, tissue and circulating genomic assessment, immunologic assessment, and patient reported outcomes (FACT-P and BPI-SF). Clinical trial information: NCT03545165.
The Politics of Fiction
Authors: Rancière Jacques
Published: March 2019

This essay uses constructions of avowed fiction from modern Western literature and criticism (Erich Auerbach, Virginia Woolf, William Faulkner) to question the sense of reality constructed by dominant social discourses that claim to be the mere expression of reality. Avowed fiction has in fact an “epistemological” privilege: it is not obliged to deny its fictional character. It must build and make visible these modes of presentation of situations and the connection of events that appear elsewhere to be imposed by the very obviousness of the real. In such a way it can better teach us the multiple ways of creating a sense of reality and their links with the forms of the social order.
The X of Representation
Authors: Marriott David
Published: March 2019

This essay is a study of the notion of representation—its relation to difference, politics, diaspora, otherness, truth, and doxa—within Stuart Hall’s work. The reevaluation of this concept in terms of dialectics and différance, or of blackness and innocence, is shown to be an abiding preoccupation of Hall’s work. In particular, because blackness (or its notion) is never innocent, this essay explores the consequences of a certain undecidability that attends any encounter between representation and difference. And it is this X—its shaping of black meaning and life—that alerts us to an unsettling tension in Hall’s work that no knowledge or encounter can fill and that leads to a purely negative reassessment of the racial imperatives of certain truths.
Cardiac phenotype in mouse models of systemic autoimmunity
Authors: Sanghera Chandan , Wong Lok Man , Panahi Mona , Sintou Amalia , Hasham Muneer , Sattler Susanne
Published: March 2019

Patients suffering from systemic autoimmune diseases are at significant risk of cardiovascular complications. This can be due to systemically increased levels of inflammation leading to accelerated atherosclerosis, or due to direct damage to the tissues and cells of the heart. Cardiac complications include an increased risk of myocardial infarction, myocarditis and dilated cardiomyopathy, valve disease, endothelial dysfunction, excessive fibrosis, and bona fide autoimmune-mediated tissue damage by autoantibodies or auto-reactive cells. There is, however, still a considerable need to better understand how to diagnose and treat cardiac complications in autoimmune patients. A range of inducible and spontaneous mouse models of systemic autoimmune diseases is available for mechanistic and therapeutic studies. For this Review, we systematically collated information on the cardiac phenotype in the most common inducible, spontaneous and engineered mouse models of systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis. We also highlight selected lesser-known models of interest to provide researchers with a decision framework to choose the most suitable model for their study of heart involvement in systemic autoimmunity.
Evolution of Polycomb-group function in the green lineage
Authors: Schubert Daniel
Published: March 2019

Epigenetic gene regulation ensures the mitotically or meiotically stable heritability (or both) of gene expression or protein activity states and maintains repetitive element repression and cellular identities. The repressive Polycomb-group (PcG) proteins consist of several large complexes that control cellular memory by acting on chromatin and are antagonized by the Trithorax-group proteins. Especially, Polycomb repressive complex 2 (PRC2) is highly conserved in plants and animals but its function in unicellular eukaryotes and during land plant evolution is less understood. Additional PcG complexes and associated proteins are only partially conserved and have evolved in a lineage-specific manner. In this review, I will focus on recent advances in the understanding of PcG function in the green lineage and its contribution to land plant evolution.
The development and evaluation of an online application to assist in the extraction of data from graphs for use in systematic reviews
Authors: Cramond Fala , O'Mara-Eves Alison , Doran-Constant Lee , Rice Andrew SC , Macleod Malcolm , Thomas James
Published: March 2019

Background:The extraction of data from the reports of primary studies, on which the results of systematic reviews depend, needs to be carried out accurately. To aid reliability, it is recommended that two researchers carry out data extraction independently. The extraction of statistical data from graphs in PDF files is particularly challenging, as the process is usually completely manual, and reviewers need sometimes to revert to holding a ruler against the page to read off values: an inherently time-consuming and error-prone process.

Methods:To mitigate some of the above problems we integrated and customised two existing JavaScript libraries to create a new web-based graphical data extraction tool to assist reviewers in extracting data from graphs. This tool aims to facilitate more accurate and timely data extraction through a user interface which can be used to extract data through mouse clicks. We carried out a non-inferiority evaluation to examine its performance in comparison with participants’ standard practice for extracting data from graphs in PDF documents.

Results:We found that the customised graphical data extraction tool is not inferior to users’ (N=10) prior standard practice. Our study was not designed to show superiority, but suggests that, on average, participants saved around 6 minutes per graph using the new tool, accompanied by a substantial increase in accuracy.

Conclusions:Our study suggests that the incorporation of this type of tool in online systematic review software would be beneficial in facilitating the production of accurate and timely evidence synthesis to improve decision-making.
Developing and implementing an interventional bundle to reduce mortality from gastroschisis in low-resource settings
Authors: Wright Naomi , Abantanga Francis , Amoah Michael , Appeadu-Mensah William , Bokhary Zaitun , Bvulani Bruce , Davies Justine , Miti Sam , Nandi Bip , Nimako Boateng , Poenaru Dan , Tabiri Stephen , Yifieyeh Abiboye , Ade-Ajayi Niyi , Sevdalis Nick , Leather Andy
Published: March 2019

Background: Gastroschisis is associated with less than 4% mortality in high-income countries and over 90% mortality in many tertiary paediatric surgery centres across sub-Saharan Africa (SSA). The aim of this trial is to develop, implement and prospectively evaluate an interventional bundle to reduce mortality from gastroschisis in seven tertiary paediatric surgery centres across SSA.

Methods: A hybrid type-2 effectiveness-implementation, pre-post study design will be utilised. Using current literature an evidence-based, low-technology interventional bundle has been developed. A systematic review, qualitative study and Delphi process will provide further evidence to optimise the interventional bundle and implementation strategy. The interventional bundle has core components, which will remain consistent across all sites, and adaptable components, which will be determined through in-country co-development meetings. Pre- and post-intervention data will be collected on clinical, service delivery and implementation outcomes for 2-years at each site. The primary clinical outcome will be all-cause, in-hospital mortality. Secondary outcomes include the occurrence of a major complication, length of hospital stay and time to full enteral feeds. Service delivery outcomes include time to hospital and primary intervention, and adherence to the pre-hospital and in-hospital protocols.  Implementation outcomes are acceptability, adoption, appropriateness, feasibility, fidelity, coverage, cost and sustainability.

Pre- and post-intervention clinical outcomes will be compared using Chi-squared analysis, unpaired t-test and/or Mann-Whitney U test. Time-series analysis will be undertaken using Statistical Process Control to identify significant trends and shifts in outcome overtime. Multivariate logistic regression analysis will be used to identify clinical and implementation factors affecting outcome with adjustment for confounders.

Outcome: This will be the first multi-centre interventional study to our knowledge aimed at reducing mortality from gastroschisis in low-resource settings. If successful, detailed evaluation of both the clinical and implementation components of the study will allow sustainability in the study sites and further scale-up.

Registration: ClinicalTrials.gov Identifier NCT03724214.
Busting common SEND myths
Authors: Freeman Garry
Published: March 2019

Since the introduction of Education, Health and Care Plans as part of the wideranging SEND reforms of 2015, some questionable practices have arisen at local authority level. SENCO Garry Freeman busts some myths about what is required and discusses practices that should be challenged…
Get work scrutiny right
Authors: Riches Adam , Watson-Davis Roy
Published: March 2019

Book scrutiny (or sampling) is too often about criticism and too often conducted in a Big Brother atmosphere of distrust. Instead, it must be about improvement, development and sharing best practice. Adam Riches and Roy Watson Davis offer their advice
Afasias de Luria: Correlação Entre o Tipo de Lesão e os Aspectos Linguísticos / Luria Aphasias: Correlation Between Type of Injury and Linguistic Aspects
Authors: Duque Anna Clara Mota , Ghirello-Pires Carla Salati Almeida
Published: March 2019

Resumo: O presente estudo tem por objetivo caracterizar as manifestações linguísticas em sujeitos afásicos e correlacionar os aspectos linguísticos identificados com a classificação das afasias proposta pelo neuropsicólogo Alexander Romanovich Luria. Os participantes da pesquisa foram oito sujeitos afásicos inseridos no Programa de Atenção Domiciliar de instituição hospitalar privada. O estudo retomou as classificações das afasias proposta por Luria, considera as questões de localização da lesão e suas manifestações, além de demonstrar que apesar de bastante aprofundada e importante para a área, à classificação Luriana, não explica certos aspectos como os relacionados às afecções do hemisfério direito.
Atividades psicomotoras em pessoas portadoras de necessidades especiais / Psychomotor Activities in People with Special Needs
Authors: Alberti Adriano
Published: March 2019

O objetivo deste trabalho foi abordar a importância das atividades psicomotoras em pessoas portadoras de necessidades especiais através de revisão bibliográfica. Inicialmente abordou-se o tema pessoas portadoras de necessidades especiais para posteriormente abordar o efeito e importância das atividades psicomotoras em pessoas portadoras de necessidades especiais. Conclui-se então que este trabalho demonstrou que apesar das pessoas portadoras de necessidades especiais apresentarem várias limitações de ordem cognitivas entre outras várias limitações, porém recebendo estímulos condizentes com sua necessidade, proporcionam melhoria na sua autonomia e também na qualidade de vida e é isso que as atividades psicomotoras proporcionam.
O Comportamento Empreendedor no Ensino Profissional e Tecnológico / Entrepreneurial Behavior in Vocational and Technological Education
Authors: Krüger Cristiane , Maciel Jéssica Da Silva , Minello Italo Fernando , Coletto Camila
Published: March 2019

Neste estudo objetivou-se analisar o comportamento empreendedor e a intenção empreendedora de alunos de graduação dos cursos de Matemática e Ciências Biológicas de um IFE. A metodologia é quantitativa, descritiva e utilizou-se de questionários para a coleta de dados. Os instrumentos são validados e correspondem ao Questionário de Intenção Empreendedora (LIÑAN, CHEN, 2009) e o de Características Comportamentais Empreendedoras (MANSFIELD et al, 1987;). Por meio de estatística descritiva, conclui-se que os discentes apresentam as dez características comportamentais empreendedoras, no entanto, estas podem ser aprimoradas. Quanto à intenção empreendedora, os alunos pesquisados apresentam baixa pretensão de empreender. Os alunos, apesar de inseridos em um IFE, desconhecem, em sua maioria, experiências empreendedoras por meio de disciplinas relacionadas. Além disso, curiosamente, os alunos com experiência profissional apresentaram menor intenção empreendedora frente aos sem tal experiência.
Readaptação Funcional: Uma voz silenciada no canto da Escola / Functional Readaptation: A Silenced Voice In The School Corner
Authors: Farias José Valvernages De , Miguel Joelson Rodrigues
Published: March 2019

A pesquisa que se propôs a entender o sentido do processo de readaptação funcional vivenciada pelos professores efetivos da rede pública municipal do município de Banabuiú-CE, discorrendo sobre os impactos que este processo produz na vida desses trabalhadores. Parte do pressuposto de que a reinserção no trabalho pela readaptação possui importante significado para o trabalhador a ser compreendido, pois seu afastamento por motivo de saúde gera uma nova condição laboral, social e simbólica, levando-o a vivenciar relações singulares sucedidas no próprio ambiente de trabalho, além de sentimentos de perda, incompreensão, frustração e fracasso, afetando não somente a sua atuação profissional, mas uma ameaça a sua própria identidade. Trata-se de uma pesquisa exploratória e qualitativa realizada por meio de entrevistas com os sujeitos em situação de readaptação funcional. Para uma melhor compreensão do estudo e avaliação dos resultados, as falas dos sujeitos foram registradas por meio de uma escuta sensível por parte do pesquisador e divididas em blocos para análises emitidas a partir dos trechos dos discursos retirados das entrevistas com os professores e gestores. Trata-se de uma forma de ordenação dos resultados, realçando o ponto de vista dos próprios trabalhadores. Os resultados demonstraram que a readaptação se efetiva em um ambiente precarizado, com relações pessoais degradantes e viabilizadas por funções desvirtuadas da sua formação profissional, que além de ser fragmentada passa a ser acompanhada por um sentimento de insegurança, desmotivação frente a sua identidade profissional. O trabalho deixa de ter o seu papel estruturante para tornar-se fonte de sofrimento e adoecimento. Apontamos como principais fontes do adoecimento docente a cobrança por resultados e o seu agravamento a falta de politicas municipais para acolher esses profissionais além da falta de sensibilização e compreensão dos professores que estão em sala de aula.
Implantação do Método Mãe Canguru: Revisão Integrativa / Implantation of the Kangaroo Mother Method: Integration Review
Authors: Teixeira Marizete Argolo , Lopes Alana Silva , Costa Elayny Lopes , Matos Robson Dos Anjos
Published: March 2019

Objetivo: realizar uma revisão integrativa da literatura sobre a implantação do Método Mãe-Canguru nas instituições brasileiras, com enfoque nas facilidades/dificuldades durante o processo da implantação. Método: Trata-se de uma revisão integrativa sobre o tema, usando periódicos de indexação e resumos, localizados na Biblioteca Virtual de Saúde. Os descritores utilizados foram: mãe-canguru, aleitamento materno, enfermagem. Para selecionar os artigos, foram elencando as publicações nacionais dos anos 2000 a 2014, escolhidas nas bases de dados: LILACS, MEDLINE, BDENF e COLECIONA SUS. Resultados: Os resultados mostraram que todas as publicações apresentaram conceitos e informações sobre o processo de implantação e que durante este processo existem dificuldades e facilidades. Conclusão: Porém, foi possível verificar que apesar de todas as publicações encontradas, ainda é incipiente o número de estudos acerca da implantação do Método Mãe-Canguru.
KATEGORI DAN EKSPRESI LINGUISTIK DALAM BAHASA SASAK PADA RANAH PERTANIAN TRADISIONAL: KAJIAN ETNOSEMANTIK
Authors: Syarifuddin Saharudin
Published: March 2019

The study aims at describing linguistic categories and expressions of traditional Sasak farmers in Lombok Island based on their social and cultural context. Qualitative method is employed in this research. The data are analyzed using componential analysis. The analysis tries to describe the lexicons and linguistic expressions on agricultural domain. The findings show that the agricultural sphere always raises the terms of the linguistic expressions/categories. Linguistic expressions form the verb and noun categories. The order of classification or the categorization of the linguistic expressions–both for the nouns and verbs– was based on the sequence of farming activities and the results obtained. Therefore, the existing categorization is based on the generic meaning components adjusted to the process and outcome—verbs and nouns—in the domain.
KLITIK –NYA DALAM BAHASA INDONESIA
Authors: Pastika I Wayan
Published: March 2019

The –nya clitic is discussable in terms of not only microlinguisctic domains (phonology, morphology and syntax) but also macrolinguistic perspectives like pragmatics and sociolinguistics. In terms of microlinguistics, there are three important findings of the –nya clitic structure : it can appear (a) as a genitive form, (b) as a definite marker, and (c) as a third person pronoun attached to different word categories (verbs, adjectives, and adverbs). Pragmatically speaking, the –nya clitic can distinguish ‘the old information’ from ‘the new one’ overtly and covertly. From the sociolinguistic point of view the –nya clitic is functioned to avoid the use of the second person that directly threatens the interlocutor’s face. The –nya clitic is also used to measure the degree of closeness between the addresser and the addressee (speech participants): the use of -nya indicates closer relationship (as in bukunya mana?), whereas the use of second person forms indicates formality (as in Dimana Buku Anda?). In informal situations, the speaker tends to choose the third person–nya as a marked form instead of the second person forms such as Anda, kamu, Saudara,  Bapak, Ibu, and Dik, which are unmarked. Therefore,  the –nya clitic is grammatically, pragmatically, and sociolinguistically very dynamic in different speech registers.
KARAKTERISTIK BAHASA INDONESIA ORANG MINANGKABAU
Authors: Almos Rona , Reniwati Reniwati , Noviatri Noviatri
Published: March 2019

The Indonesian is multi spoken languages society. Besides speaking with the official language (bahasa Indonesia), they also speaking in their own mother language. The use of local languages or the mother tongue is preferably as second language. Therefore, the acquisition of Indonesian, especially for Minangkabau society is strongly influenced by the structure of the first language. This is called as dialect or style.  Slang or style can be seen from the lingual units that used by the speakers of the language. Lingual unit is a unit of language that carries meaning, both lexical and grammatical meaning. Unit lingual include morphemes, words, phrases, clauses, sentences, and discourse. In addition, there is another element which is the smallest unit in the language, segmental elements (phonemes) and supra-segmental elements (intonation). The results of the data analysis showed that there are some unit lingual speech marking Indonesian Minang people, namely: elements of segmental and supra-segmental elements, phatic, and sentence structure. In term of segmental elements, I have found six phonemes in Minangkabau language that affects Indonesian, phonemes are: /e/, /p/, /s/, /k/, and /j/. Moreover, in supra-segmental elements it appears that there tends to tone up the filler constituent predicate function. In declarative sentences, tone up there on the last syllable. In interrogative sentences, tone up tens to present in interrogative qualifiers. In imperative sentences, the intonation rising filler constituents tend be found in the predicate function, especially on the final syllable.
IDENTIFIKASI, OEDIPUS-KOMPLEKS DAN KRISIS PARUH BAYA DALAM MIDNIGHT ALL DAY KARYA HANIF KUREISHI: PEMBACAAN PSIKOANALISIS
Authors: Rokhman Muh Arif
Published: March 2019

The research is aimed at looking at social relationship and personal problems in the United Kingdom through the eyes of a Pakistani-British writer, Hanif Kureishi. This will be done through the possibility of applying three psychoanalytic concepts, namely identification, Oedipus complex and midlife crisis to literary works. The short stories selected were ‘Strangers when we meet’, ‘That was then’, and ‘Girl’ which were published in Midnight All Day, a short story collection written by Hanif Kureishi, an English writer. The analysis was conducted on the characters of the stories which were subjected to the concepts. The results revealed that the concepts could be applied to the relevant characters. Besides, through the applications, we can see the problems experienced by the characters in the story which may reflect the real people in the United Kingdom.
ABSURDITAS DAN INDIVIDUALITAS DALAM ROMAN L’ÉTRANGER KARYA ALBERT CAMUS (KAJIAN SEMIOLOGI ROLAND BARTHES)
Authors: Sunahrowi Sunahrowi
Published: March 2019

L’Étranger’s influence on literature, especially on Existentialism, has attracted literary writers and critics. In order to find a text’s meaning and to give a more comprehensive attention to meaning dimension and text plurality, Roland Barthes classified signifiers in narrative discourse into a series of concise and coherent fragments called lexias. And finally, individuality and absurdity constitute the main spirits in Existentialism. L’Étranger expresses aloud these two things just as how Albert Camus shouts out loud his ideology – Existentialism, in each of his works.
Penerjemahan Teks Suci: Analisis Ketepatan Terjemahan Istilah Kecendekiaan Dalam Alquran dan Terjemahnya
Authors: Syihabuddin Syihabuddin
Published: March 2019

This research aims to determine the accuracy of the translation of scholarly terms, namely ulū al-albāb, ulū al-‘ilm, ulū al-nuhā, and ulū al-abṣār in the holy scripture of Alquran and its translation, published by the Department of Religious Affairs of the Republic of Indonesia. In addition,the factors influencing the accuracy of the translation is analysed. To meet the aim, the data on scholarly terms and their translations were collected using Q-soft ELRA software version 1.0.0. The data were then analysed semantically by comparing both the lexical and contextual meanings in their source and target languages. Based on the analysis and discussion, it is found that the terms ulū al-albāb, ulū al-‘ilm, ulu an-nuhā, and ulū al-abṣār are translated in various ways. Ulū al-albāb and ulū an-nuha are translated quite accurately, ulū al-‘ilm accurately, and ulū al-abṣār rather inaccurately. The levels of accuracy are influenced by the translation techniques that is used, cultural differences, and inaccuracy in understanding the lexical meanings. The four terms describe the semantic relations from the most specific to the most general, namely ulū al-albāb, ulū al-nuhā, ulū al-abṣār, and ulū al-‘ilm respectively.
PENYIMPANGAN MAKNA DAN PERUBAHAN KONSTITUEN DALAM HUMOR CAK LONTONG
Authors: Sukardi Mochamad Ighfir , Yuwana Rawuh Yuda , Sumarlam Sumarlam
Published: March 2019

The purposes of this research are (1) to describe the deviation of meaning in Cak Lontong’s humor materials (2) to describe the changing of constituent in Cak Lontong’s humor materials. This research is a descriptive-qualitative research. Listening method is used as the  data collecting technique, using technique of tap and write. The data analysis method is the reference equalization, using comparative technique to support codification, reduction, presentation, and interpretation. The results of this research are: Cak Lontong exploits gaps and possibilities of new meanings that can be used in words; Cak Lontong deviates meanings by establishing the second meaning as an effort to give surprise to his listeners; and Cak Lontong exploits figurative words of homonymy, e.g. “mengarungi” and “ngurusi” to play the meanings that are conveyed in using the language. The power of Cak Lontong’s humor is in the sensitivity in finding gaps of words, then presenting them by trapping listener’s interpretation to the unintended meanings. A changing constituent occurs to function of process to be participant, participant to participant, participant to circumstances, and circumstances to circumstances. It changes meanings and interpretations of a same word.
HUMOR TERKAIT MU’AMMAR AL-QAŻĀFI (ANALISIS PRAGMATIK)
Authors: Saputro Septian
Published: March 2019

Humour functions as a critic, satire, irony or propaganda. By using humour, it is posible to say the truth elegantly and sofly, without disturbing others’ feeling. In pragmatic comunication theory, humour is created from deviations of comunication principles, e.g: Grice principle of comunication and Leech principle of comunication. This research uses the jokes on the former leader of Libyan Mu’ammar al-Qażāfi as the object material. Mu’ammar al-Qażāfi was the leader of controversy as well as he was a dictator. Then, there are assumptions that the humours about al-Qażāfi are not only about entertaiment but also about special aims. The researcher uses pragmatic analysis that covers Grice cooperative principle, Leech politeness principle and speech acts (illocutionary act). The results are that political humour in Libyan was a new kind of humour and it was developed while the revolution was on and in the aftermath. While Ilocutionart Acts, which are found in the humours about al-Qażāfi, are irony, claiming, ordering, complaining, and satiring. The aims in the humours are satire and irony.
Components of Financial Literacy of Young People
Authors: Hornyák Andrea
Published: March 2019

The financial crisis has drawn attention to the importance of the population’s financial literacy. I am investigating assessment methodologies to evaluate financial literacy both from the point of view of macroeconomics and microeconomics in my study. I am of the opinion that the elaboration of the financial competency model based on international database is the solution that can lead to the determination of conditions of financial awareness by collectively investigating financial education, core competencies, and the psychological role of money. I surveyed the financial knowledgeability of Hungarian high school students with the help of field research after assessing the OECD and PISA findings. I received very different results of knowledge, behaviour, and attitudes by school type, gender, age-group, and family background, which might support the assessment of financial literacy indicators, the evaluation of results, and international comparisons.
The Influence of Entrepreneurship Education on the Entrepreneurial Intentions of University Students in Katsina State, Nigeria
Authors: Mamman Aliyu , Olaoye Ismail Kayode , Abdulrahaman Abdulrazaq M. , Shagari Jibrin Nuhu , Lekan Olusegun Kazeem
Published: March 2019

This study attempts to determine the influence of Entrepreneurship Education (EEd) on the entrepreneurial intentions of university students in Katsina State, Nigeria. The study is guided by the following specific objectives: to examine the nature of entrepreneurial education being acquired by the students to determine the extent of influence of the acquired education on the students’ entrepreneurial self-efficacy and to determine the extent of influence of the acquired education on student’s entrepreneurial mindset. Secondary and primary sources were used in generating data for the study. Using stratified and random sampling techniques, data was generated by means of a structured questionnaire administered to 400 students across the three universities in the State. Descriptive statistics as well as simple regression was used in analysing the data collected from the respondents. Findings revealed that students fairly agreed that they have acquired education in major areas of entrepreneurship encompassing creativity, innovation, and venture creation and that EEd has a significantly positive influence on their entrepreneurial self-efficacy and entrepreneurial mindset. The study recommends that university managements should devise means of an adequate follow-up of their graduates to ensure the translation of their entrepreneurial intentions into venture creation, while entrepreneurship education lecturers should pay special attention to the area of venture creation as the students do not seem to be very optimistic in their ability to translate business opportunities into business projects/ventures.
Determinants of Automated Teller Machine Usage in Lagos State, Nigeria
Authors: Ighomereho Salome , Ladipo Patrick , Dixon-Ogbechi Bolajoko
Published: March 2019

Research has shown that ATMs provide an extremely useful service to customers but the machine is characterized by several service quality inadequacies, and at times it can be very frustrating to use. Consequently, this study investigated socio-demographic factors and service quality dimensions as determinants of ATM usage in Lagos State, Nigeria. A questionnaire was used to collect data from bank customers who use ATM and the data were analysed using General Linear Model (GLM) and multiple regression. The results from the analyses reveal that socio-demographic factors, such as age, education, and income, influence ATM usage, while gender and occupation do not influence ATM usage. The study also revealed that all the service quality dimensions identified in the study have a significant positive influence on ATM usage. When the joint effect of socio-demographic factors and service quality dimensions on ATM usage was assessed, it was found that service quality had a greater influence on ATM usage than socio-demographic factors.