bluuebunny/crossref_metadata_2025 huggingface dataset:
Neoadjuvant teriparatide therapy targeting the osteoporotic spine: influence of administration period from the perspective of bone histomorphometry
Authors: Sawakami Kimihiko , Watanabe Kei , Hasegawa Kazuhiro , Yamamoto Noriaki , Shimakura Taketoshi , Ohashi Masayuki , Shoji Hirokazu , Mizouchi Tatsuki , Tanaka Yuki , Segawa Hiroyuki , Ishikawa Seiichi , Hirano Toru , Kawashima Hiroyuki , Endo Naoto , Takahashi Hideaki E.
Published: October 2021

OBJECTIVE

Teriparatide (TPTD) is a potent promoter of early-stage osteogenesis and may be a useful adjuvant therapy to reduce complications related to bone fragility in spinal surgery patients with osteoporosis. However, effective neoadjuvant TPTD therapy regimens remain poorly understood. This study aimed to examine the effect of preoperative TPTD administration on cancellous bone with bone histomorphometry and to clarify the timing of preoperative TPTD administration for patients with spinal fusion and osteoporosis.

METHODS

In this longitudinal multicenter study, 57 patients with spinal fusion and osteoporosis, who consented to undergo iliac biopsy, were allocated to the following treatment groups: neoadjuvant TPTD therapy group (n = 42) and no neoadjuvant therapy (NTC) group (n = 15). Patients in the TPTD group were categorized into subgroups on the basis of duration of preoperative TPTD administration, as follows: 1 month (n = 9), 2 months (n = 8), 3 months (n = 9), 4 months (n = 7), and 6 months (n = 9). All patient samples were preoperatively double labeled with tetracycline, and iliac biopsies were performed during spinal fusion surgery. Histomorphometric analyses were performed on nondecalcified, thin-sliced specimens. Specimens were classified on the basis of TPTD administration duration and subsequently compared with those of the NTC group. Postoperative complications and Oswestry Disability Index scores were evaluated at 1 and 2 years after surgery.

RESULTS

There were no demographic differences between groups. Mineralizing surface/bone surface, a key parameter of dynamic bone formation, started to increase after 1 month of TPTD administration; this increase became significant after 3 months of administration and peaked at 4 months, with a 6-fold increase relative to that of the NTC group. The patients who received preoperative TPTD for 3 months or more had superior clinical results in terms of the osteoporotic complication rate and Oswestry Disability Index scores, except for bisphosphonate-pretreated patients.

CONCLUSIONS

When considering neoadjuvant TPTD therapy, the authors recommend at least 3 months of preoperative administration to provide a more substantial anabolic effect from the early postoperative stage.
Cauda equina ependymomas: surgical treatment and long-term outcomes in a series of 125 patients
Authors: Marchesini Nicolò , Tommasi Nicola , Faccioli Franco , Pinna Giampietro , Sala Francesco
Published: October 2021

OBJECTIVE

Cauda equina ependymoma (CEE) is a rare tumor for which little information is available on the oncological and clinical outcomes of patients. In this study the authors aimed to address functional, oncological, and quality-of-life (QOL) outcomes in a large series of consecutive patients operated on at their institution during the past 20 years.

METHODS

The records of 125 patients who underwent surgery between January 1998 and September 2018 were reviewed. Analyzed variables included demographic, clinical, radiological, surgical, and histopathological features. Neurological outcomes were graded according to the McCormick and Kesselring scales. The QOL at follow-up was evaluated by administering the EQ-5DL questionnaire.

RESULTS

On admission, 84% of patients had a McCormick grade of I and 76.8% had a Kesselring score of 0. At follow-up (clinical 8.13 years; radiological 5.87 years) most scores were unchanged. Sacral level involvement (p = 0.029) and tumor size (p = 0.002) were predictors of poor functional outcome at discharge. Tumor size (p = 0.019) and repeated surgery (p < 0.001) were predictors of poor outcome. A preoperative McCormick grade ≥ III and Kesselring grade ≥ 2 were associated with worse outcomes (p = 0.035 and p = 0.002, respectively). Myxopapillary ependymoma (MPE) was more frequent than grade II ependymoma (EII). The overall rate of gross-total resection (GTR) was 91.2% and rates were significantly higher for patients with EII (98%) than for those with MPE (84%) (p = 0.0074). On multivariate analysis, the only factor associated with GTR was the presence of a capsule (p = 0.011). Seventeen patients (13.7%) had recurrences (13 MPE, 4 EII; 76.4% vs 23.6%; p = 0.032). The extent of resection was the only factor associated with recurrence (p = 0.0023) and number of surgeries (p = 0.006). Differences in progression-free survival (PFS) were seen depending on the extent of resection at first operation (p < 0.001), subarachnoid seeding (p = 0.041), piecemeal resection (p = 0.004), and number of spine levels involved (3 [p = 0.016], 4 [p = 0.011], or ≥ 5 [p = 0.013]). At follow-up a higher proportion of EII than MPE patients were disease free (94.7% vs 77.7%; p = 0.007). The QOL results were inferior in almost all areas compared to a control group of subjects from the Italian general population. A McCormick grade ≥ 3 and repeated surgeries were associated with a worse QOL (p = 0.006 and p = 0.017).

CONCLUSIONS

An early diagnosis of CEE is important because larger tumors are associated with recurrences and worse functional neurological outcomes. Surgery should be performed with the aim of achieving an en bloc GTR. The histological subtype was not directly associated with recurrences, but some of the features more commonly encountered in MPEs were. The outcomes are in most cases favorable, but the mean QOL perception is inferior to that of the general population.
Simple parameters of synthetic MRI for assessment of bone density in patients with spinal degenerative disease
Authors: Chang Hsuan-Kan , Hsu Tun-Wei , Ku Johnson , Ku Jason , Wu Jau-Ching , Lirng Jiing-Feng , Hsu Shih-Ming
Published: October 2021

OBJECTIVE

Good bone quality is the key to avoiding osteoporotic fragility fractures and poor outcomes after lumbar instrumentation and fusion surgery. Although dual-energy x-ray absorptiometry (DEXA) screening is the current standard for evaluating osteoporosis, many patients lack DEXA measurements before undergoing lumbar spine surgery. The present study aimed to investigate the utility of using simple quantitative parameters generated with novel synthetic MRI to evaluate bone quality, as well as the correlations of these parameters with DEXA measurements.

METHODS

This prospective study enrolled patients with symptomatic lumbar degenerative disease who underwent DEXA and conventional and synthetic MRI. The quantitative parameters generated with synthetic MRI were T1 map, T2 map, T1 intensity, proton density (PD), and vertebral bone quality (VBQ) score, and these parameters were correlated with T-score of the lumbar spine.

RESULTS

There were 62 patients and 238 lumbar segments eligible for analysis. PD and VBQ score moderately correlated with T-score of the lumbar spine (r = −0.565 and −0.651, respectively; both p < 0.001). T1 intensity correlated fairly well with T-score (r = −0.411, p < 0.001). T1 and T2 correlated poorly with T-score. Receiver operating characteristic curve analysis demonstrated area under the curve values of 0.808 and 0.794 for detecting osteopenia/osteoporosis (T-score ≤ −1.0) and osteoporosis (T-score ≤ −2.5) with PD (both p < 0.001).

CONCLUSIONS

PD and T1 intensity values generated with synthetic MRI demonstrated significant correlation with T-score. PD has excellent ability for predicting osteoporosis and osteopenia.
Do We Need an International Instrument for the Recognition of the Right to a Healthy Environment?
Authors: Jahan Ishrat
Published: October 2021

Environmental degradation is continuing globally despite various international environmental treaties. If the right to a healthy environment is recognised by a global instrument, this international recognition of this right could enhance the implementation and enforcement of various multilateral environmental agreements. Moreover, the international recognition of this right to a healthy environment could create a level playing field at the international level to ensure better balancing of competing interests. Furthermore, an international instrument for the recognition of this right is necessary to address many environmental challenges including climate change, the loss of biodiversity, marine pollution, long-range air pollution and plastic pollution which have global or trans-boundary dimensions. A second optional protocol to the ICESCR as an international instrument for the recognition of the right to a healthy environment could be adopted. It would be the best option for the adoption of an international instrument to recognise the right to a healthy environment.
From training to learning: Transition of a workplace for industry 4.0
Authors: Rassameethes Bordin , Phusavat Kongkiti , Pastuszak Zbigniew , Hidayanto Achmad Nizar , Majava Jukka
Published: October 2021

BACKGROUND: Transition into Industry 4.0 has had many significant impacts. Customization symbolizes leanness, flexibility, adaptability, and agility. A business operator needs to recognize the factors that contribute to better utilization of the talents of its workforce and more effective workplace learning. OBJECTIVE: The study aims to provide a construct which highlights effective workplace learning. In this context, a construct represents a broad view of various interrelated ideas and concepts which can point to academic and practical implications. METHODS: The study applies action research which is suitable when observing a transformative change. The study intends to observe and notice how the environmental factors have changed and try to predict their impacts on human capital development. To help verify the suitability of these impacts, a comparison with similar studies or findings is made. Focuses on literature reviews which look at the impacts from Industry 4.0 (on a need to tackle the waste of the talents in a workplace), recent developments of learning (on an emerging importance of informal learning), and survey’s data (on a shift in a workplace’s expectation on the workers). RESULTS: Workplace learning has gradually replaced training and education. The proposed construct can help tackle the underutilization of the talents in a workplace as the workers are nowadays expected to perform the tasks and learn at the same time. CONCLUSIONS: Sustaining learning in a workplace needs to understand behavior, motivation, emotion, and workplace engagement. Informal learning, which reflects the individualization of learning, can enable an organization to deal with workplace learning.
Feasibility and Preliminary Efficacy of an Internet-Delivered Intervention for Insomnia in Individuals with Mild Cognitive Impairment
Authors: Mattos Meghan K. , Manning Carol A. , Quigg Mark , Davis Eric M. , Barnes Laura , Sollinger Ann , Eckstein Michelle , Ritterband Lee M.
Published: October 2021

Background: Approximately 50% of older adults with cognitive impairment suffer from insomnia. When untreated, pre-existing cognitive problems may be exacerbated and potentially contribute to further cognitive decline. One promising approach to maintain cognitive health is to improve sleep quantity and quality. Objective: To determine feasibility, acceptability, and preliminary efficacy of Sleep Health Using the Internet for Older Adult Sufferers of Insomnia and Sleeplessness (SHUTi OASIS), an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) program in older adults with mild cognitive impairment (MCI). Methods: Older adults with MCI and insomnia were recruited from hospital-based memory and sleep disorders clinics and enrolled in a single-arm pilot study. Participants completed the six cores of SHUTi OASIS, over nine weeks with two-week baseline and post-assessments using self-reported sleep diaries. Feasibility and acceptability were informed by usage statistics and qualitative interviews; preliminary efficacy was informed by patient-generated sleep data. Results: Twelve participants enrolled and, on average, were 75.8 years of age. Ten participants completed the study and logged in most days. Most participants reported a positive overall experience, and interviews revealed successful and independent program management and completion. There were significant changes on all baseline to post-assessment sleep measures, including clinically meaningful improvements on the Insomnia Severity Index (13.5 to 8.3, p < 0.01), sleep efficiency, wake after sleep onset, and sleep onset latency (ps < 0.02). There was no statistically significant change in cognitive measures (p > 0.05). Conclusion: This study supports that older adults with cognitive impairment can independently complete CBT-I via the Internet and achieve clinical sleep improvements.
Alzheimer’s Disease Diagnostics Must Be Globally Accessible
Authors: Clute-Reinig Nicholas , Jayadev Suman , Rhoads Kristoffer , Le Ny Anne-Laure
Published: October 2021

Dementia and Alzheimer’s disease (AD) are global health crises, with most affected individuals living in low- or middle-income countries. While research into diagnostics and therapeutics remains focused exclusively on high-income populations, recent technological breakthroughs suggest that low-cost AD diagnostics may soon be possible. However, as this disease shifts onto those with the least financial and structural ability to shoulder its burden, it is incumbent on high-income countries to develop accessible AD healthcare. We argue that there is a scientific and ethical mandate to develop low-cost diagnostics that will not only benefit patients in low-and middle-income countries but the AD field as a whole.
Impairment of Episodic-Specific Autobiographical Memory in Individuals with Subjective Cognitive Decline and in Patients with Prodromal or Mild Alzheimer’s Disease
Authors: Bruus Anna E. , Waldemar Gunhild , Vogel Asmus
Published: October 2021

Background: Autobiographical memory (AM) is a personal form of memory that becomes impaired in the early, clinical stages of Alzheimer’s disease (AD). In the “preclinical” phase of AD, neuropathological hallmarks are present (especially in a brain network underpinning AM), but performance on standardized neuropsychological tests is normal. Even so, some patients have subjective cognitive decline (SCD). Objective: The aim was to 1) investigate AM performance on two tests with different approaches in SCD, and in prodromal and mild AD, and 2) examine the association between the AM tests. Methods: We included 17 SCD patients with heightened risk of AD, 17 amnestic mild cognitive impairment (aMCI) patients, 17 patients with mild dementia due to AD, and 30 healthy controls. Patients were diagnosed according to international criteria, and all participants had MMSE scores≥24. AM was assessed using the Columbia Autobiographical Memory Interview-Short Form (CAMI-SF) and the Three Events Test. These tests measure the production of contextual details. Results: Significant group effects were found for the Three Events Test and the CAMI-SF. All patient groups produced significantly fewer contextual details than the controls on the Three Events Test. On CAMI-SF, the aMCI and mild AD groups were able to answer fewer questions or gave significantly less detailed answers than the other groups. The SCD patients performed below the controls on CAMI-SF, but the difference was not significant. Conclusion: AM may be impaired in very early AD, even in the phases where standardized episodic memory tests show no decline.
A unique approach of person reidentification using auto track regression framework
Authors: Sworna Kokila M.L. , Gomathi V.
Published: October 2021

Automatic Person Re-identification by video surveillance is commonly used in different applications. Perhaps the human uniqueness criteria for tracking the presence of the same person across multiple camera views and a person’s growth identification is extremely challenging. To solve the above problem, we propose an efficient Auto Track Regression System (ATRF) based on a deep learning technique that uses an eminent representation strategy along with recognition. In this work, the Auto Wiley Detective (AWD) approach is proposed for the representation of features that can collect valuable information by monitoring individuals. After obtaining important information on the characteristics, it is possible to define the personal growth identity of the generation. The OPVC (Original Pick Virtual Classifier) is used for accurate classification of the queried person from a dense area by utilizing features of a person’s growth identity extracted from feature extraction by the Auto Wiley Detection Method. The proposed Originated Pick Virtual Classifier (OPVC) uses Platt scaling (originated pick) on probit regression (virtual) to train the featured data set for accurate person re-identification, which is boosted by the Karush–Kuhn–Tucker (KKT) conditions to reduce false re-identification. Since the gallery information is trained using the Backpropagation method and smoothened analysis through approximated output, the Auto Wiley Detection Method proficiently detects the required information automatically. This also helps to detect the person query image from the database, which contains a vast collection of video images based on the similarity features identified in the query image and the detailed features extracted from the query image. The classification is completed automatically, and then the Person Re-Identification from the databases is performed accurately and efficiently. Henceforth, the proposed work effectively extracts reliable height and age estimates with improved flexibility and individual re-identifying capabilities.
Generalized neighborhood systems-based pessimistic rough sets and their applications in incomplete information systems
Authors: Pang Jing , Yao Bingxue , Li Lingqiang
Published: October 2021

In this paper, we point out that Lin’s general neighborhood systems-based rough set model is an extension of Qian’s optimistic rough set model, and thus called optimistic general neighborhood systmes-based rough set model. Then we present a new rough set model based on general neighborhood systems, and prove that it is an extension of Qian’s pessimistic rough set model. Later, we study the basic properties of the proposed pessimistic rough sets, and define the serial, reflexive, symmetric, transitive and Euclidean conditions for general neighborhood systems, and explore the further properties of related rough sets. Furthermore, we apply the pessimistic general neighborhood systems-based rough set model in the research of incomplete information system, and build a three-way decision model based on it. A simple practical example to show the effectiveness of our model is also presented.
An improved method for satellite emergency mission scheduling scheme group decision-making incorporating PSO and MULTIMOORA
Authors: Yan Bing , Wang Yanjun , Xia Wei , Hu Xiaoxuan , Ma Huawei , Jin Peng
Published: October 2021

Satellite emergency mission scheduling scheme group decision making (SEMSSGDM) is a key part of satellite mission scheduling research. An appropriate evaluation model can provide a dependable and sustainable improvement and guide the functioning of emergency mission scheduling. Consequently, this research is devoted to proposing a novel decision-making method that employs a novel consensus model with hesitant fuzzy 2-tuple linguistic sets (HF2TLSs) to eliminate disagreements among satellite dispatchers and reach consensus in scheme decision-making. Within the novel method, it proposes a distance measurement function based on Hausdorff distance with HF2TLS to gauge the fit and similarity across satellite dispatchers. Additionally, a consensus reaching process (CRP) is designed to adjust the judgement of satellite dispatchers taking into account the trust degree to improve consensus. Within the selection process, a combination of the particle swarm optimization (PSO) algorithm and the MULTIplicative MOORA (MULTIMOORA) method is applied, where PSO is performed to improve the accuracy of information aggregation, and the MULTIMOORA method is used to develop the robustness of the selection results. Lastly, an applicative example validates the effectiveness of the method based on a mission scheduling intelligent decision simulation system.
Kiwifruit supplementation increases the gene expression of ATP-binding cassette transporter A1 and Liver X receptor α in liver and intestine of hamsters fed with high-fat diet
Authors: Moradi Saba , Tavilani Heidar , Saidijam Massoud , Hashemnia Mohammad , Vaisi-Raygani Asad
Published: October 2021

BACKGROUND: Liver X receptor α (LXRα) and ATP-binding cassette transporter A1 (ABCA1) as a lipid transporter play an important role in cholesterol efflux from cells. OBJECTIVE: This study was aimed to determine the effect of kiwifruit supplementation on LXRα and ABCA1 gene expressions in liver and intestine of hamsters fed with high-fat diet (HFD). METHODS: 36 Golden Syrian male hamsters were divided into 6 groups (n = 6) including, group 1 received chow diet (control normal), group 2 and 3 received chow diet plus 1.86 and 3.73 g/kg kiwifruit, group 4 received HFD, group 5 and 6 received HFD plus 1.86 and 3.73 g/kg kiwifruit for 8 weeks. RESULTS: ABCA1 gene expression were significantly decreased in the liver (p <  0.01) and the intestine (p <  0.05) of HFD group compared with control normal. The gene expression levels of ABCA1 from liver and intestine were increased in HFD treated with kiwifruit compare to untreated HFD group (p <  0.05). LXRα gene expression of intestine was increased in all of the kiwifruit treated groups compared with untreated groups (p <  0.05). CONCLUSIONS: Consumption of kiwifruit in in hamsters receiving HFD can improve cholesterol efflux from liver and intestine by increase the gene expression of ABCA1 and LXRα.
Association study of rs17782313 polymorphism near MC4R gene with obesity/overweight, BMI, and hedonic hunger among women from Northwestern Iran
Authors: Narjabadifam Mahan , Bonyadi Morteza , Rafat Seyed Abbas , Mahdavi Reza , Aliasghari Fereshteh
Published: October 2021

BACKGROUND: Obesity, as a medical condition, results from interactions between environmental and genetic factors. The rs17782313 polymorphism, located 188kb downstream of the Melanocortin 4 Receptor (MC4R) gene, is one of the essential candidate genetic markers that has shown the highest association with obesity in different populations. OBJECTIVE: This study aimed to investigate the possible associations of rs17782313 polymorphism near the MC4R gene with obesity/overweight, body mass index (BMI), and hedonic hunger among women from the Iranian Azeri ethnic group. METHODS: Five hundred sixty-three women, composed of 396 patients with obesity/overweight and 167 unrelated healthy controls, were genotyped for the rs17782313 polymorphism by applying the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method. RESULTS: This population was in Hardy-Weinberg equilibrium (P = 0.878). The study confirmed a significant association of rs17782313 with obesity, where subjects carrying the C/C genotype had higher odds of obesity (OR = 2.681, P = 0.005, 95%CI:1.340–5.365). Also, C allele carriers have statistically significantly higher BMI scores than those carrying the T allele (P = 0.029). However, no significant associations were found among PFS scores and genotypic/allelic groups of rs17782313 polymorphism (P = 0.368). CONCLUSIONS: Our findings suggest that rs17782313 polymorphism is strongly associated with obesity and BMI but not with hedonic hunger among Northwest Iran women. Moreover, the sequencing data analysis in several homozygous and heterozygous carriers of the C allele led to identifying a novel frameshift variant with TCT deletion (rs534212081) in the 166 upstream of rs17782313, which has not been reported so far.
Effect of synbiotic supplementation on asprosin level in high fat diet-induced metabolic disorder in pregnant rats
Authors: Naghizadeh Mehrdad , Karajibani Mansour , Fanaei Hamed , Montazerifar Farzaneh , Dashipour Alireza
Published: October 2021

Synbiotic supplementation can improve metabolic disorders. The aim of this study was to assess the impact of synbiotic supplementation on the levels of asprosin, lipid profile, glucose, and insulin resistance in pregnant rats fed a high-fat diet (HFD). Rats were divided into three groups: control group (fed base chow), HFD group, and HFD + synbiotic group. Levels of blood glucose, total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), insulin, and asprosin levels were measured. Birth weight of offspring in the HFD + synbiotic group was significantly lower than in the HFD group. Similarly, serum asprosin, insulin, insulin resistance, TG and total cholesterol levels in the HFD + symbiotic group were significantly lower than in the HFD group. Asprosin levels had a significant and positive correlation between food intake in the first ten days of the experiment and gestation period, fasting blood sugar (FBS), TG, and homeostatic model assessment (HOMA) index. Moreover, asprosin levels had a significant and negative correlation with HDL and insulin levels. Results showed, synbiotic supplementation has beneficial effects on obese animals and improves weight gain during pregnancy, pup birth weight, FBS, insulin resistance and lipid profile. These advantages of synbiotic supplementation could be mediated by reducing serum asprosin levels.
Seeding metastases: The role and clinical utility of circulating tumour cells
Authors: Patel Deep A. , Blay Jonathan
Published: October 2021

Peripheral human blood is a readily-accessible source of patient material in which circulating tumour cells (CTCs) can be found. Their isolation and characterization holds the potential to provide prognostic value for various solid cancers. Enumeration of CTCs from blood is becoming a common practice in informing prognosis and may guide therapy decisions. It is further recognized that enumeration alone does not capture perspective on the heterogeneity of tumours and varying functional abilities of the CTCs to interact with the secondary microenvironment. Characterizing the isolated CTCs further, in particular assessing their functional abilities, can track molecular changes in the disease progress. As a step towards identifying a suite of functional features of CTCs that could aid in clinical decisions, developing a CTC isolation technique based on extracellular matrix (ECM) interactions may provide a more solid foundation for isolating the cells of interest. Techniques based on size, charge, density, and single biomarkers are not sufficient as they underutilize other characteristics of cancer cells. The ability of cancer cells to interact with ECM proteins presents an opportunity to utilize their full character in capturing, and also allows assessment of the features that reveal how cells might behave at secondary sites during metastasis. This article will review some common techniques and recent advances in CTC capture technologies. It will further explore the heterogeneity of the CTC population, challenges they experience in their metastatic journey, and the advantages of utilizing an ECM-based platform for CTC capture. Lastly, we will discuss how tailored ECM approaches may present an optimal platform to capture an influential heterogeneous population of CTCs.
ПАРАДИГМА ФОРМУВАННЯ МЕХАНІЗМУ ЗМІЦНЕННЯ ЕКОНОМІЧНОЇ БЕЗПЕКИ ПІДПРИЄМНИЦЬКОЇ ДІЯЛЬНОСТІ
Authors: Калінеску Тетяна Василівна , Ревенко Даніїл Сергійович , Підмогильний Сергій Сергійович
Published: October 2021

Economic security embraces all spheres of activity, and brings neglect over by it’s to the negative (catastrophic) consequences, decline of different aspects of development the industries of economy, separate types of enterprise. Therefore there is a requirement in forming a paradigm of mechanism the strengthening economic security of entrepreneurial activity in obedience to the doctrines of economy development of Ukraine. A research aim is directed on forming of effective mechanism of strengthening economic security according to terms of business development, dynamics of moving the national economy, level of innovative diffusions and existent internal and external calls. Methodological basis of research became modern normative, legal, legislative aspects of strengthening economic security and eliminated of existent threats in the process of business developments. In the researches was using methods of dialectics, principles of scientific cognition, instruments of economic analysis for the sake of forming the effective mechanism of strengthening economic security of enterprise. The basic hypothesis of research became supposition about possibility of creation of universal mechanism of strengthening economic security that can provide stable development of entrepreneurial activity in the different spheres of national economy. Exposition of basic material. in the article are investigated the threats that influence on economic security of enterprise. Underline, that each of  threats can have the mechanisms strengthening of economic security, that consist with facilities, instruments, methods and forms composition, that it can be enough unique, depending on the type of enterprise. Originality and practical meaningfulness of research are confirmed by the offered composition of facilities, methods, forms and instruments of mechanism the strengthening of economic security that it is universal from one hand, and from other is allowing to tune the specific of activity the separate type of enterprise. Conclusions and prospects of further researches. It is well-proven that the mechanism of strengthening the economic security of enterprise must provide possibilities of the effective functioning of business and be the element of mechanism the economic security of the system of higher level. For every businessman there are the absolutely individual approaches to forming of mechanism the strengthening of economic security that depends from material and technical and financial resources, quality and structure of management entrepreneurial activity; state and regional support, legislative and legal base of functioning. Further researches will be directed on adaptation of the offered mechanism of strengthening the economic security, its monitoring and correcting, going out the requirements of internal and external environment of business and dynamics of global economic changes
ІНСТИТУЦІЙНІ АСПЕКТИ УПРАВЛІННЯ ПОДАТКОВИМ ПОТЕНЦІАЛОМ ПРОМИСЛОВОСТІ
Authors: Омельяненко Віталій Анатолійович
Published: October 2021

The priority direction of tax policy is the formation of tax potential, which includes the creation of conditions for the intensification of entrepreneurial activity, the formation of active development actors, the expansion of sources of tax revenue, the stimulation of innovation and investment activity. At the same time, in Ukraine, the lack of systemic directions of tax incentives for innovation in the legislation and practice of tax instruments significantly hinders the development of innovation potential of the economy and reduces its competitiveness. The basis for improving tax policy in the context of innovative development is the institutional component. The purpose of the study is to identify promising institutional aspects of the formation of tax potential in industry. The methodological basis of the study were analytical reviews, regulations, modern scientific and applied research in the field of innovation. The research uses methods of dialectics, methods and principles of scientific knowledge, tools of economic analysis to substantiate proposals for the formation of institutional foundations for the formation of tax potential. The main hypothesis of the study was the assumption that tax policy, which is aimed at developing innovation, largely determines the economic interest of industrial enterprises in the introduction of new technologies, as financial resources released from the tax potential of the enterprise can be directed to its innovation and investment activity. Presenting main material. The strategic task of tax potential management is to increase and strengthen the tax base by stimulating investment and innovation activity; support of enterprises in order to develop production and increase production. The tax potential is considered in the context of institutional innovation projects and smart specialization. An assessment of the prospects for the use of various tax instruments in accordance with the current situation and the need for the transition to adaptive management of tax potential of industry. The originality and practical significance is confirmed by the proposed scientific and methodological approaches to the management of tax potential in the context of innovative development. Conclusions and prospects for further research. Measures to increase the tax potential should include expanding the tax base not only through existing reserves, but also creating a new base through the development of innovation potential. The implementation of the relevant institutional strategy should be aimed not at simple maximization of tax revenues, but at the development of investment and innovation potential with the establishment of favorable conditions for the development of priority projects. Further research will focus on the analysis of the peculiarities of the use of tax tools in the framework of specific institutional and innovative projects of economic development.
Application of the Professional Psychological Quest in the Professional Training of Police Officers
Authors: Мілорадова Н. Е. , Твердохлєбова Н. Є.
Published: October 2021

The results of the analysis of foreign and domestic approaches to the interpretation and understanding of quest technologies are presented. It is noted that in order to create the proper conditions for the formation of future police officers professional competence, motivational focus on positive personal changes and the desire for professional self-development, it is advisable to use the possibilities of innovative teaching technologies, in particular, trainings and quests. During such classes, participants have the opportunity to learn how to quickly make the right decisions within the limits of their professional competence, applying the obtained theoretical knowledge, as well as to master and consolidate the necessary skills. The educational quest is highlighted as a separate form of design technologies. The features of the developed professional-psychological police quest with elements of the training "Features of the district police officer’s activities" are revealed, its consistent stages are characterized: organizational and preparatory, implementation and final. It is noted that the basis of the police quest is the situational method, the content of which is aimed at mastering the algorithm of actions by the cadets associated with the implementation of the service tasks of the police. It has been revealed that the use of a professional-psychological police quest is an active form of group work and provides the use of set measures aimed at increasing the level of professional training of police officers, developing and changing the structure of interpersonal relations, educational and professional motivation, and contributes to the self-realization of the individual within the professional space. The authors emphasize the advisability of using a police quest, which contributes to the increase of professional competence level due to the increase of the study time amount allocated for practical work, the independent acquisition and use of new knowledge and skills in practice, making the right decisions within the framework of their professional competence, and well-coordinated teamwork.
Issues of Legal Regulation of Applying Coercive Measures of Medical Nature in International and Legal Acts and Legislation of Certain Foreign Countries
Authors: Туренко Д. В.
Published: October 2021

The author has researched the main provisions of legal regulation in international and legal acts and national laws of some European Union countries and other foreign countries, where the possible application of coercive measures of a medical nature by courts, as well as decisions of the European Court of Human Rights on this category of criminal proceedings are regulated. The basic provisions, norms and differences of legal regulation of the application of coercive measures of medical nature in the legislation of certain foreign countries have been established. The implementation of international legal acts into national criminal, criminal procedural and other legislation has been analyzed. Based on the results of the research, the author has formulated a number of propositions and recommendations for the introduction into the legislative technique of Ukraine. Besides, the author has studied national theoretical issues of criminal law and criminal proceedings, as well as applied issues in this area of the research within law-enforcement activities of pre-trial investigation and inquiry agencies, prosecutor’s office and, in particular, procedural commissioners of pre-trial investigation. The scientific views of individual scholars and representatives of scientific schools on the researched issues have been also considered, and the relevant author’s opinions have been expressed. The author has characterized joint law-enforcement activities, problematic issues of law enforcement agencies and psychiatric medical institutions during the pre-trial investigation of criminal proceedings of this category, problematic issues and the existing system for providing psychiatric care to insane persons, as well as certain areas of cooperation in criminal and judicial proceedings. According to the results of the study, the author has suggested a number of propositions and recommendations for improving the theory of criminal law and criminal proceedings, law-enforcement activity and current criminal and criminal procedural legislation of Ukraine.
PLANNING OF SPATIAL DEVELOPMENT OF THE CITY
Authors: Bezlyubchenko O. , Apatenko T.
Published: October 2021

The work is devoted to the consideration of the concepts of the spatial development of the cities of Ukraine taking into account today's specifics of the formation of institutes of their management. The issues discussed in this article are relevant to almost any city in modern Ukraine at the stage of transition of the country from industrial to post-industrial type. Among the most pressing issues are the rational use of territorial resources and environmental security within urban systems. There is also a trend of uneven economic development in urban areas. The solution to this problem is the balanced development of urban space with a diversified economy and infrastructure, as well as high quality of life. The formation of multifunctional urban areas will ensure sustainable spatial development of the city and significantly affect the quality of life. Identifying areas within the city that are inefficiently used and have additional development potential will provide an important resource, which, unlike remote areas, is already provided with transport and engineering infrastructure. Efficient use of territorial resources will allow the formation of a rational compact planning structure of the city. The housing of high quality should be provided with the necessary social and transport infrastructure, be diverse, medium, and multi-story.
Comfortable stay of citizens in public spaces involves the integration of public spaces into the cultural life of the city based on the expansion of existing and introduction of new functional content, including the implementation of commercial initiatives and their use in organizing important socio-cultural projects. A comfortable stay in the city largely depends on the architectural appearance of its historic and modern buildings. Existing buildings create the front line of streets, form the environment of public spaces, define the line of the city silhouette.
Filling the existing recreational areas included in the system of public spaces with new meanings to citizens.
Fertilización in vitro (FIV) de ovocitos obtenidos en ovejas mediante la técnica de recolección laparoscópica de óvulos
Authors: Ugalde Julio Ramón , Cervera Paúl Deneb , Domínguez Rebolledo Álvaro , Baeza-Rodríguez Juan , Pinzón-López Luis , Zamora-Bustillos Roberto
Published: October 2021

Con el objetivo de poner a punto la técnica de recolección laparoscópica de óvulos (LOPU) y desarrollar un protocolo de fertilización in vitro (FIV) dos grupos de ovejas; el primero, G1, con 3 prepúberes y G2, con 3 adultas, fueron sincronizadas (esponjas vaginales 14 días) y superovuladas (FSHp), iniciando 60 h antes de cada LOPU (tres sesiones). La aspiración folicular laparoscópica se realizó a las 12 h de la última dosis de FSHp. La tasa de recuperación global de los ovocitos en tres sesiones de LOPU en el G2 y G1, fue de 41.0 ± 2.5 y 24.0 ± 2.4% EEM, respectivamente, presentando diferencias (P < 0.05) a favor del G2. El cultivo in vitro de los ovocitos a las 48 h presenta una diferencia (P < 0.05) a favor del G1 (9.7%) respecto aG2 (0.0).
Pulpotomía utilizando extracto de orégano como alternativa en el tratamiento de dientes temporales
Authors: Orellana-Centeno José Eduardo , Gaytán-Hernández Darío , Nava-Calvillo Jaime Francisco
Published: October 2021

El formocresol es uno de las sustancias más empleadas para la terapia dental de la pulpotomía en la Odontpediatría debido a sus efectos tóxicos, genotóxicos y mutagénicos; por dicha razón es que se está constantemente buscando nuevas alternativas para dicho tratamiento con el uso de distintas sustancias o medicamentos. Este es un estudio experimental básico en donde se recolectaron 20 muestras de órganos dentarios de pacientes con edades que oscilaban entre los tres y nueve años de la Clínica de Odontopediatría de Pregrado de la Facultad de Estomatología de la U. A. S. L. P. que cumplieron con los criterios de inclusión para el tratamiento de pulpotomías. El tratamiento se realizó de acuerdo con los lineamientos de la AAPD, con excepción de que se utilizó extracto hidroalcohólico 70:30 de orégano y se midió en el laboratorio su capacidad para eliminar microorganismos.
Incidental prostate cancer diagnosed after surgical treatment of benign prostatic hyperplasia
Authors: İlktaç Abdullah , Ersöz Cevper , Doğan Bayram , Akçay Muzaffer , Yıldız Pelin , Çoban Ganime , Akbulut Habib
Published: October 2021

Objective: Incidental prostate cancer (PCa) is defined as the clinically inapparent tumor detected after transurethral resection of prostate (TURP) or open prostatectomy with benign preoperative rectal examination, prostate specific antigen (PSA) and imaging. The aim of this study is to determine the incidence and clinical significance of incidental prostate cancer in our clinic. Material and Methods: A retrospective analysis was performed in patients who were treated with TURP or transvesical open prostatectomy (TVP) between January 2014 and December 2019. Age, prostate volume, preoperative PSA value, Gleason score, ISUP score, stage and presence of previous prostate biopsy were noted. Treatment performed for incidental PCA was determined. Results: A total of 1020 patients were surgically treated for benign prostate hyperplasia between January 2014 and December 2019. Incidental PCa was diagnosed in 57 (5.6%) patients. 51 (89%) of the patients had TURP and 6 (11%) had TVP. Mean age was 69.9±7.1 years and mean PSA value was 5.3±4.8 ng/ml. Majority of the patients (82.4%) had a Gleason score of 6 (3+3) and 37 (64.9%) patients were reported as stage 1a. Patients with preoperative prostate biopsy have significantly higher prostate volume and PSA values compared to the patients without biopsy (p<0.01). Active surveillance was performed in 42 patients, 2 patients underwent radical prostatectomy, 6 patients had radiotherapy and 7 patients had androgen blockade. Conclusion: We have an incidental PCa rate similar to the literature. Majority of the patients have stage 1a disease and a Gleason score of 6. Most of the patients were managed conservatively. Keywords: incidental prostate cancer, benign prostate hyperplasia, transurethral resection of prostate
Effect of obesity on percutaneous nephrolithotomy outcomes in Staghorn stones
Authors: Şahan Murat , Erdemoğlu Onur
Published: October 2021

Objective: In this study, we aimed to compare the success and complication rates of percutaneous nephrolithotomy (PCNL) in obese patients with staghorn renal stones. Material and Methods: Between January 2012 and December 2017, 183 patients who had single access PCNL for staghorn renal calculi were evaluated retrospectively. Patients were divided into two groups according to body mass index (BMI). The patients with BMI < 30 kg/mm2 and >30 kg/mm2 were defined group-1 and group-2, respectively. Among the groups, we compared demographic characteristics, perioperative and postoperative datas. Postoperatively, >4 mm stone was identified as residual fragment. Complications were classified according to the Clavien scoring system. Results: In our study, there were 127 and 56 patients with staghorn renal calculi in the Group-1 and Group-2, respectively. The mean BMI were 24.5±2.7 kg/mm2 and 32.3±2.2 kg/ mm2 in the Group-1 and Group-2, respectively ( p=0.001). The number of patients with metabolic syndrome was also statistically significant higher in group-2 ( p=0.001). The mean stone size were 848±302 mm2 and 1020±197 mm2 in the Group-1 and Group-2, respectively ( p=0.535). Operation, nephroscopy and fluoroscopy times were similar between the groups (p=0.800, p=0.123, p=0.107 respectively). When we evaluated the postoperative results, stone-free rates were 55.6% and 62.5% in group-1 and group-2, respectively (p=0.381). Total complication rates were 38.9% and 33.9% in group-1 and group-2, respectively (p = 0.523). Investigating the subgroups of complications according to the Clavien scoring system, the rate of minor complications were 27.6% and 25.0% in the group-1 and group-2, respectively and this difference was not statistically significant (p = 0.697). Major complication rates were 11.0% and 8.9% in the group-1 and group-2, respectively (p=0.657). Conclusion: PCNL is an effective and safe treatment method for staghorn stones in obese patients. Keywords: Percutaneous nephrolithotomy, Staghorn renal calculi, Clavien scoring system, obesity, body mass index.
Mardin ve Batman Ekolojik Koşullarında Bazı Mısır (Zea Mays L.) Genotiplerinin İkinci Ürün Olarak Performanslarının Karşılaştırılması
Authors: DUMAN Ahmet , EKİNCİ Remzi
Published: October 2021

Bu çalışma, Mardin Artuklu ve Batman Beşiri ekolojik koşullarında ikinci ürün olarak bazı at dişi mısır çeşitlerinin verim ve bazı unsurlarına yönelik performanslarının belirlenmesi amacı ile yürütülmüştür. Deneme, 2020 yılında Mardin ve Batman ekolojik koşullarında ikinci ürün olarak, 10 adet çeşit bitkisel materyal olarak kullanılarak, tesadüf blokları deneme deseninde 3 tekrarlamalı olarak kurulmuştur. Çalışmada, bitki boyu (cm), ilk koçan yüksekliği (cm), koçan sırasında tane sayısı (adet); koçanda sıra sayısı (adet), hektolitre ağırlığı (kg), tane verimi (kg/da), tane protein oranı (%) ve tanede yağ içeriği (%) özellikleri incelenmiştir. İncelenen tüm özelliklerde lokasyon ve çeşitler arasındaki farklılıklar istatistiki olarak önemli bulunurken, koçan sırasında tane sayısı, hektolitre ağırlığı ve tane verimi özelliklerinde interaksiyon arasındaki farklılıklar istatistiki olarak önemli bulunmuştur. İkinci ürün koşullarında incelenen tüm özelliklerde genetik yapı ve çevre koşullarının oldukça etkili olduğu; Mardin lokasyonu erkenci mısır çeşitlerin, Batman lokasyonlarında ise çok erkenci mısır çeşitlerin daha iyi performans gösterdiği sonucuna varılmıştır. MAY M16G44, P0573, P32T83 ve Capuzi çeşitleri Mardin lokasyonunda, Arabat, Chonhar, Kakhovskyi, Skadovski, SY Tuscany ve Tronca çeşitlerinin ise Batman lokasyonunda ikinci ürün olarak yetiştirilmesi önerilmektedir.