bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined Pre-Treatment Technologies for Cleaning Biogas before Its Upgrading to Biomethane: An Italian Full-Scale Anaerobic Digester Case Study
Authors: Le Pera Adolfo , Sellaro Miriam , Pellegrino Crescenzo , Limonti Carlo , Siciliano Alessio
Published: March 2024

Biogas produced by anaerobic digestion contains different types of contaminants, and it is preferable to eliminate those contaminants before biogas’ energetic valorization or upgrading to biomethane as they are harmful to human health and detrimental to combustion engines. This study presents the biogas cleanup system optimized by an Italian full-scale anaerobic digester treating food waste (FW) and represented by micro-oxygenation, chemical scrubber, cooling, and activated carbon sections. The cleaned biogas is upgraded to biomethane using a membrane-based upgrading unit and injected into the natural gas network for transport sector use. H2S and volatile organic compound (VOC) concentration in raw biogas was reduced from an annual average value of 1207 ppmv and 895 mg/Nm3, respectively, to below 0.1 mg/Nm3 in the final biomethane. In the summer, the H2S average content in raw biogas was 833 ppmv due to a greater presence of low-sulfur-containing vegetables in FW, while in the winter it was an average of 1581 ppmv due to a larger portion of protein-containing FW. On the other hand, raw biogas VOC content in the winter was an average of 1149 mg/Nm3, with respect to 661 mg/Nm3 in the summer, due to the greater consumption of citrus fruits containing high amount of terpene compounds. The concentration of other trace contaminants, such as HCl, NH3, and siloxanes, was lowered from 17, 36, and 0.6 mg/Nm3 in raw biogas, respectively, to below 0.1 mg/Nm3 in the final biomethane. All the considerations and evaluations underlying the technological and plant engineering choices together with the individuation of the best operating conditions are discussed.
Caries in Primary Molars: Is Silver Diamine Fluoride Effective in Prevention and Treatment? A Systematic Review
Authors: Inchingolo Francesco , Inchingolo Alessio Danilo , Latini Giulia , Sardano Roberta , Riccaldo Lilla , Mancini Antonio , Palermo Andrea , Inchingolo Angelo Michele , Dipalma Gianna
Published: March 2024

In recent years, pediatric dentistry has evolved considerably in terms of both the techniques and materials used. A clear, odorless liquid called silver diamine fluoride (SDF) is recommended for molars affected by hypoplasia and dentinal hypersensitivity. In adults and children who are at a high risk of developing caries, it is also helpful to prevent the progression of carious lesions. Teeth too compromised to be reconstructed that are not accompanied by discomfort or infection can be treated with SDF. The current review aims to provide an overview of the most recent research over the last 10 years on the potential of SDF, focusing on the clinical evidence of professionally applied fluoride therapy to prevent and arrest caries in children’s primary molars. Research was conducted according to the guidelines of the PRISMA statement. “silver diamine fluoride”, “primary molar”, and “primary molars” were the search terms utilized on the databases Scopus, Web of Science, and PubMed, with the Boolean operator “AND” and “OR”. Of these 195 studies, 13 primary studies were included in this review. The quality of the included papers was assessed using the reputable Cochrane risk of bias assessment for randomized trials. The studies reviewed consistently support the effectiveness of SDF in stopping the progression of existing caries in deciduous molars; on the contrary, there is insufficient evidence to draw conclusions about SDF being effective for the prevention of carious lesions in deciduous molars.
Formulation and Characterization of Experimental Adhesive Systems Charged with Different Concentrations of Nanofillers: Physicomechanical Properties and Marginal Gap Formation
Authors: Correia Camila Rodrigues Paiva , Poskus Laiza Tatiana , Guimarães José Guilherme Antunes , Penelas Alice Gonçalves , Amaral Cristiane Mariote , da Silva Machado Rayane Fernandes , da Silva Eduardo Moreira
Published: March 2024

This study aimed to formulate and characterize experimental dental adhesives charged with different concentrations of nanofillers. Different concentrations (0, 7.5 wt%, and 15 wt%) of nanosized silica (50 nm) were added to the bond of a two-bottle experimental etch-and-rinse adhesive system (EA0, EA7.5, and EA15). The following physicomechanical properties were evaluated: degree of conversion (DC%), ultimate tensile strength (UTS), flexural strength (FS), static modulus of elasticity (SME), dynamic modulus of elasticity (DME), and glass transition temperature (Tg). Marginal integrity (%MG) was evaluated in standardized class I cavities hybridized with the EAs and restored using two dental composites (CON-conventional and OBF-bulk-fill): EA0CON, EA7.5CON, EA15CON, EA0OBF, EA7.5OBF, and EA15OBF. Gap formation was measured in the occlusal and mesial tooth-restoration interfaces using a 3D laser confocal microscope. Microtensile bond strength (µTBS) was evaluated using dentin-composite beams (1 × 1 mm) obtained from restorations. Data were submitted to ANOVA and Tukey’s test (α = 0.05). For DC% and Tg, EA15 < EA0 = EA7.5 (p < 0.05). For UTS, EA0 < EA7.5 < EA15. For FS, SME, and DME, EA0 < EA7.5 = EA15 (p < 0.05). For the gap formation analysis, there were statistical differences only for the conventional composite (EA0CON > EA7.5CON = EA15CON). The lowest values (p < 0.05) of µTBS were observed for the groups restored with EAs without inorganic content. In conclusion, charging dental adhesives with nanofillers may be a suitable strategy for improving their properties as well as their interaction with dental substrates.
Interaction of Selected Commercial Antiseptics with Natural Products against Methicillin-Resistant Staphylococcus aureus Strain
Authors: Sienkiewicz Monika , Młodzińska Paulina , Kilanowicz Anna , Dudzińska Ewa , Kwiatkowski Paweł
Published: March 2024

The carriage of methicillin-resistant S. aureus (MRSA) strains may determine the subsequent occurrence of infection, which mainly affects patients after surgeries. Therefore, its eradication with the use of antibiotics or antiseptics is a crucial method of preventing staphylococcal self-infections. The observed increase in bacterial resistance to known antibacterial substances poses a huge challenge to scientists. The aim of this study was to analyze the interaction of selected commercial antiseptics (Braunol, CITROclorex 2%, Microdacyn 60 Wound Care, Octenisept and Prontoderm Solution) with natural products (carvacrol, β-citronellol, geraniol, eugenol, farnesol, (-)-menthone, eucalyptol, limonene, linalyl acetate and trans-anethole) against the MRSA standard strain. The antistaphylococcal activity of commercial antiseptics in combination with natural products against MRSA was determined using the checkerboard method. The obtained results showed that most combinations decreased the MIC level of the commercial antiseptic and natural compounds. A statistically significant decrease in the MIC value of the antiseptic and natural constituent was observed for the Braunol–β-citronellol combination. Such a significant decrease in the MIC value of the natural compound against the analyzed strain was also detected for the Octenisept–β-citronellol and Prontoderm Solution–β-citronellol combinations. The interaction analysis showed that out of all 20 combinations of individual antiseptics with substances of natural origin, two combinations showed a synergistic effect (Braunol–β-citronellol, Braunol–carvacrol), and three combinations showed an additive effect (Braunol–eugenol, Braunol–geraniol, Prontoderm Solution–β-citronellol). The use of Braunol in combination with β-citronellol or carvacrol may become an alternative method of eradicating MRSA strains. However, further studies are needed to determine the toxicity of the analyzed combinations.
Deformation and Energy Absorption Performance of Functionally Graded TPMS Structures Fabricated by Selective Laser Melting
Authors: Song Jian , Wang Mengkang , Li Dongming , Zhang Jun
Published: March 2024

Triply periodic minimal surface (TPMS) structures have unique geometries and excellent mechanical properties, which have attracted much attention in many fields. However, the relationship between different filling forms and different directions of functionally graded TPMS structures on energy absorption has not been fully studied. In this study, a functionally graded strategy was proposed to investigate the effect of filling form and direction gradient on the energy absorption of TPMS structures. The design of functionally graded Gyroid and Diamond TPMS cellular structures with multiple forms was characterized, and the structures were fabricated using additive manufacturing technology. The effects of uniformity and different directional gradients on the deformation and energy absorption properties of the structures were studied experimentally and numerically. According to the compression test results, it was found that different filling forms of the TPMS structure behave differently in terms of yield plateau and deformation pattern, and the sheet structures can develop a better deformation pattern to enhance energy absorption capacity. Functionally graded sheet Diamond TPMS cellular structures along the compression direction exhibit a 32% reduction in initial peak force, providing more advantages in structural deformation and energy absorption. More closely, it is possible to further reduce the initial peak force, delay the densification point, and thus increase the energy absorption capacity by designing functionally graded sheet Diamond TPMS based cellular structures. The results of this study provide valuable guidance for the design of high-performance impact-protection components.
A Multiuser, Multisite, and Platform-Independent On-the-Cloud Framework for Interactive Immersion in Holographic XR
Authors: Neeli Hosein , Tran Khang Q. , Velazco-Garcia Jose Daniel , Tsekos Nikolaos V.
Published: March 2024

Background: The ever-growing extended reality (XR) technologies offer unique tools for the interactive visualization of images with a direct impact on many fields, from bioinformatics to medicine, as well as education and training. However, the accelerated integration of artificial intelligence (AI) into XR applications poses substantial computational processing demands. Additionally, the intricate technical challenges associated with multilocation and multiuser interactions limit the usability and expansion of XR applications. Methods: A cloud deployable framework (Holo-Cloud) as a virtual server on a public cloud platform was designed and tested. The Holo-Cloud hosts FI3D, an augmented reality (AR) platform that renders and visualizes medical 3D imaging data, e.g., MRI images, on AR head-mounted displays and handheld devices. Holo-Cloud aims to overcome challenges by providing on-demand computational resources for location-independent, synergetic, and interactive human-to-image data immersion. Results: We demonstrated that Holo-Cloud is easy to implement, platform-independent, reliable, and secure. Owing to its scalability, Holo-Cloud can immediately adapt to computational needs, delivering adequate processing power for the hosted AR platforms. Conclusion: Holo-Cloud shows the potential to become a standard platform to facilitate the application of interactive XR in medical diagnosis, bioinformatics, and training by providing a robust platform for XR applications.
Flexural Behavior of a New Precast Insulation Mortar Sandwich Panel
Authors: Zhang Mingshan , Feng Weirong , Chen Kepeng , Li Benyue
Published: March 2024

This article introduces the experimental and analytical research results of two precast insulation mortar concrete sandwich panels (PIMSP) and two precast concrete composite panels as one-way slabs under bending load. Obtaining a prefabricated floor slab that can balance thermal insulation and structural performance can reduce material consumption and increase inter-story usage height. As the sandwich material for PIMSP, insulation mortar with a strength of 6 MPa was used. Truss-shaped shear connectors were used for shear force transfer. Then, finite element analysis was used to analyze and study the unidirectional flat plate model. The results showed that the tested PIMSP achieved a complete composite effect in the elastic stage and a semi-composite effect in the plastic stage. The PIMSP crack pattern resembles that of a precast concrete slab when utilized as a one-way slab. The load transfer capacity of truss-shaped shear connectors is relatively small, and it is mainly used as a connection between floors. Experiments have demonstrated that PIMSP panels can serve as a structural substitute for regular concrete floors in residential buildings.
Smart Materials for Control of Structural Dynamics
Authors: Palacz Magdalena , Krawczuk Marek
Published: March 2024

Problems related to controlling the dynamics of machines and devices have been a major engineering challenge for many decades [...]
Stability Analysis of Three-Dimensional Tunnel Face Considering Linear and Nonlinear Strength in Unsaturated Soil
Authors: Yang Yushan , Liao Hong , Zhu Jianqun
Published: March 2024

The shear strength of unsaturated soils exhibits significant nonlinearity, while previous studies often simplified it with linear strength models. The objective of this paper is to investigate the distinctions in the stability of three-dimensional (3D) tunnel faces when using linear and nonlinear strength models. A new 3D rotational failure mechanism and an extended form of the Mohr–Coulomb (M-C) failure criterion were integrated into the kinematically limited analysis (KLA) framework to describe the failure characteristics of tunnel faces. Subsequently, the factor of safety (FS) of the 3D tunnel faces was calculated using the strength reduction method (SRM). In the discussion section, the impacts of nonlinear shear strength, matric suction in the unsaturated soils, and the 3D geometric parameters of the tunnel on the stability of the tunnel face were analyzed. The outcomes indicate that, in unsaturated soil conditions, diverse nonlinear strength calculation models and soil types exert disparate influences on the FS of 3D tunnel faces. The main novelty of this study lies in establishing an effective method for assessing the stability of tunnel faces in unsaturated soils.
The Characteristics of the Deformation of a Feeding Roller with Double V-Wings Honeycomb under Driven Modes with Different Rotation Rates and Axial Compressions
Authors: Zhou Wenhui , Wang Dian
Published: March 2024

In this work, the roller-shaped double V-wing honeycomb (DVWH) structure was used as the object, which was designed for forest harvesting machines. The deformation characteristics of its rotation under a specific compression were studied during the feeding process for the steel feeding roller used in the traditional combined harvesting machine for trees, which is prone to damaging the wood. The compression rate (10%–15%) and rotational speed (100 mm/s–320 mm/s) were used to analyze the relationship between compression rate, rotational speed, and deformation characteristics. The deformation characteristics, characterized by equivalent stress, radial displacement sensitivity, and energy absorption efficiency, were analyzed. The results show that the deformation characteristics of the roller-shaped DVWH structure under driven mode were more sensitive to compression rate and less sensitive to changes in rotational speed. There was a positive correlation between the equivalent stress of the node and the compression rate. The peak equivalent stress of the outermost node at 10% and 15% compression rates were 111.9 MPa and 230.9 MPa. There was a negative correlation between radial displacement–compression sensitivity and compression rate, and a decrease in radial displacement–compression sensitivity from 10% to 15% compression rate at different nodes ranges from 5% to 22%. The feed performance efficiency (EF) grew from 8.3% to 12.7% for a 1% increase in compression rate.
Investigation of Failures during Commissioning and Operation in Photovoltaic Power Systems
Authors: Gökgöz Metin , Sağlam Şafak , Oral Bülent
Published: March 2024

Considering global warming and environmental problems, the importance of renewable energy sources is increasing day by day. In particular, the effects of wind and solar power, which are variable renewable power sources, on the power system necessitate their evaluation in terms of the reliability of the power system. Photovoltaic panels, which enable the conversion of solar power into electrical power with semiconductors, have started to take an important place in global energy investments today. Photovoltaic power plants increase the demand for this energy source with continuous energy conversion depending on sunshine duration and radiation intensity. Among the renewable energy sources, the most easily utilized energy source, regardless of geographical conditions, is the sun. To prevent the energy production of PV power plants from being interrupted, it is necessary to address and analyze all kinds of faults that will affect power production in order to increase the reliability of the system. Academic studies in this field are generally grouped under two topics: classification of faults or modeling of electrical faults. Based on this, in this study, the problems that occur during the installation and operation of photovoltaic systems are classified, and the relevant faults are modeled and simulated in MATLAB Simulink version 23.2 (R2023b). Thus, a scientific approach to the problems of photovoltaic power plant operating conditions has been gained, which will be the basis for academic studies.
A Practical Deep Learning Architecture for Large-Area Solid Wastes Monitoring Based on UAV Imagery
Authors: Liu Yang , Zhao Bo , Zhang Xuepeng , Nie Wei , Gou Peng , Liao Jiachun , Wang Kunxin
Published: March 2024

The development of global urbanization has brought about a significant amount of solid waste. These untreated wastes may be dumped in any corner, causing serious pollution to the environment. Thus, it is necessary to accurately obtain their distribution locations and detailed edge information. In this study, a practical deep learning network for recognizing solid waste piles over extensive areas using unmanned aerial vehicle (UAV) imagery has been proposed and verified. Firstly, a high-resolution dataset serving to solid waste detection was created based on UAV aerial data. Then, a dual-branch solid waste semantic segmentation model was constructed to address the characteristics of the integration of solid waste distribution with the environment and the irregular edge morphology. The Context feature branch is responsible for extracting high-level semantic features, while the Spatial feature branch is designed to capture fine-grained spatial details. After information fusion, the model obtained more comprehensive feature representation and segmentation ability. The effectiveness of the improvement was verified through ablation experiments and compared with 13 commonly used semantic segmentation models, demonstrating the advantages of the method in solid waste segmentation tasks, with an overall accuracy of over 94%, and a recall rate of 88.6%—much better than the best performing baselines. Finally, a spatial distribution map of solid waste over Jiaxing district, China was generated by the model inference, which assisted the environmental protection department in completing environmental management. The proposed method provides a feasible approach for the accurately monitoring of solid waste, so as to provide policy support for environmental protection.
Dynamic Correlation between Platelet Aggregation and Inflammatory-like State in Athlete Horses
Authors: Arfuso Francesca , Rizzo Maria , Arrigo Federica , Faggio Caterina , Giudice Elisabetta , Piccione Giuseppe , Giannetto Claudia
Published: March 2024

This study aimed to assess the effect of exercise on serum electrophoretic protein pattern, C-reactive protein (CRP) and platelet aggregation in horses subjected to a jumping exercise. The possible relationship between acute-phase reactions and platelet reactivity in the context of exercise was investigated. Blood samples were collected from 10 jumper horses at rest (TREST), within 5 min from the end of exercise (TPE5), and 30 min (TPE30) and 60 min after exercise (TPE60). The serum values of total proteins; CRP; albumin; α1-, α-2, β1-, β2- and γ-globulins; and the maximum degree of aggregation and the initial velocity of aggregation (slope) were evaluated. According to one-way analysis of variance, CRP and α1-, α-2, β1- and β2-globulins increased after exercise compared with rest condition (p < 0.001), whereas albumin and platelet aggregation showed lower values after exercise than at rest (p < 0.001). CRP and α1-globulin values were negatively correlated with both platelet aggregation indices at TPE5, whereas no significant correlation among these parameters was found at TREST, TPE30 and TPE60. This study provides evidence that an acute-phase response occurred in horses after the jumping exercise and suggests a linkage between the inflammatory status and the platelet responsiveness in horses during exercise.
Jewish “Ghosts”: Judit Hersko and Susan Hiller and the Feminist Intersectional Art of Post-Holocaust Memory
Authors: Bloom Lisa E.
Published: March 2024

This article delves into the underexplored intersection of Jewish identities and feminist art. It critically examines artworks by Judit Hersko and Susan Hiller, aligning with evolving identity constructs in contemporary aesthetics. Concepts like “postmemory” link second-generation Jewish artists to past experiences and unveil the erasure of Jewish women’s memory of Jewish genocide. Analyzing Hersko and Hiller’s diverse works, from landscape photography and sculpture to performance art, it underscores their shared pursuit: illuminating lingering “ghosts” of the Holocaust in modern landscapes. Susan Hiller’s The J Street Project represents an ongoing exploration of loss and trauma beyond the Holocaust in Germany, using archives as a dynamic, evolving phenomenon. Judit Hersko’s art calls for bearing witness to a potential climate catastrophe in Antarctica. The article culminates in the exploration of “The Memorial” (2017), an art project by the activist collective Center for Political Beauty that focuses on the resurgence of overt anti-Semitism in Germany. In essence, Hiller and Hersko confront erasures in history and nature, emphasizing justice and repair. Their art, intertwined with a project addressing contemporary anti-Semitism, serves as a testament to the enduring power of feminist art, reflecting, mourning, and transforming a world marked by historical traumas and war.
Comparison of Different Impact Factors and Spatial Scales in PM2.5 Variation
Authors: Zhou Hongyun , Dai Zhaoxin , Wu Chuangqi , Ma Xin , Zhu Lining , Wu Pengda
Published: March 2024

PM2.5 particles with an aerodynamic diameter of less than 2.5 μm are receiving increasing attention in China. Understanding how complex factors affect PM2.5 particles is crucial for the prevention of air pollution. This study investigated the influence of meteorological factors and land use on the dynamics of PM2.5 concentrations in four urban agglomerations of China at different scales from 2010 to 2020, using the Durbin spatial domain model (SDM) at five different grid scales. The results showed that the average annual PM2.5 concentration in four core urban agglomerations in China generally had a downward trend, and the meteorological factors and land use types were closely related to the PM2.5 concentration. The impact of temperature on PM2.5 changed significantly with an increase in grid scale, while other factors did not lead to obvious changes. The direct and spillover effects of different factors on PM2.5 in inland and coastal urban agglomerations were not entirely consistent. The influence of wind speed on coastal urban clusters (the Pearl River urban agglomeration (PRD) and Yangtze River urban agglomeration (YRD)) was not significant among the meteorological factors, but it had a significant impact on inland urban clusters (the Beijing–Tianjin–Hebei urban agglomeration (BTH) and Chengdu–Chongqing urban agglomeration (CC)). The direct effect of land use type factors showed an obvious U-shaped change with an increase in the research scale in the YRD, and the direct effect of land use type factors was almost twice as large as the spillover effect. Among land use type factors, human factors (impermeable surfaces) were found to have a greater impact in inland urban agglomerations, while natural factors (forests) had a greater impact in coastal urban agglomerations. Therefore, targeted policies to alleviate PM2.5 should be formulated in inland and coastal urban agglomerations, combined with local climate measures such as artificial precipitation, and urban land planning should be carried out under the consideration of known impacts.
Examination of the Influence of Alternative Fuels on Particulate Matter Properties Emitted from a Non-Proprietary Combustor
Authors: Smith Liam D. , Harper Joseph , Durand Eliot , Crayford Andrew , Johnson Mark , Coe Hugh , Williams Paul I.
Published: March 2024

The aviation sector, like most other sectors, is moving towards becoming net zero. In the medium to long term, this will mean an increase in the use of sustainable aviation fuels. Research exists on the impact of fuel composition on non-volatile particulate matter (nvPM) emissions. However, there is more sparsity when considering the impact on volatile particulate matter (vPM) emissions. Here, nine different fuels were tested using an open-source design combustor rig. An aerosol mass spectrometer (AMS) was used to examine the mass-loading and composition of vPM, with a simple linear regression algorithm used to compare relative mass spectrum similarity. The diaromatic, cycloalkane and aromatic contents of the fuels were observed to correlate with the measured total number concentration and nvPM mass concentrations, resulting in an inverse correlation with increasing hydrogen content. The impacts of fuel properties on other physical properties within the combustion process and how they might impact the particulate matter (PM) are considered for future research. Unlike previous studies, fuel had a very limited impact on the organic aerosol’s composition at the combustor exit measurement location. Using a novel combination of Positive Matrix Factorization (PMF) and high-resolution AMS analysis, new insight has been provided into the organic composition. Both the alkane organic aerosol (AlkOA) and quenched organic aerosol (QOA) factors contained CnH2n+1, CnH2n−1 and CnH2n ion series, implying alkanes and alkenes in both, and approximately 12% oxygenated species in the QOA factor. These results highlight the emerging differences in the vPM compositional data observed between combustor rigs and full engines.
Inter-Comparison of Lightning Measurements in Quasi-Linear Convective Systems
Authors: Ringhausen Jacquelyn , Chmielewski Vanna , Calhoun Kristin
Published: March 2024

Data from four lightning networks collected during three quasi-linear convective systems (QLCS) are used to understand the differences in detection for optimizing their combined use. Additionally, using unique aspects from each network provides a more complete picture of lightning in a thunderstorm. The four lightning networks examined include a Lightning Mapping Array (LMA), the Earth Networks Total Lightning Network (ENTLN), the Geostationary Lightning Mapper (GLM), and the National Lightning Detection Network (NLDN). The data from each network are inter-matched and locations where each network uniquely detected a flash versus all are analyzed in reference to three QLCSs, including two QLCSs that occurred in the Southeast (22 March 2022 and 30 March 2022) during the Propagation, Evolution, and Rotation in Linear Systems (PERiLS) field campaign, and one case from Oklahoma (26 February 2023). Unique aspects of the lightning provided by each network are examined, including flash initiation altitude, size, type, and energy. Lightning flash trends and characteristics for each QLCS are similar between networks in general, but deviate in certain conditions and locations. Times of decreased matching between networks were associated with localized increases in lightning rates, smaller flash sizes, and lower-energy flashes. The differences in each network’s performance across the QLCSs demonstrates the importance of understanding the limitations in each and the advantage of using multiple networks.
Attenuation of Ultraviolet Radiation by Aerosols and Clouds in Beijing Area in 2005–2020
Authors: Zhao Shuman , Xin Huajian , Wu Shumin , Sun Yankun , Hu Bo
Published: March 2024

Ultraviolet radiation (UV) has strong chemical and biological effects on human health and ecosystems, and it plays an important role in the atmospheric environment by affecting photochemical processes, etc. Clouds and aerosols are the main factors affecting UV radiation and analyzing the quantitative impact of them on UV radiation is of great significance. Using the observation data of UV radiation in Beijing from 2005 to 2020, as well as the data of aerosol optical depth (AOD), single scattering albedo (SSA), and other related parameters, this paper simulated the surface UV radiation in two scenarios of cloudless without aerosol and cloudless with aerosol based on the TUV (Tropospheric Ultraviolet-Visible model), and quantitatively evaluated the attenuation of UV radiation by aerosol and cloud in the Beijing area. The results show that UV radiation is more sensitive to changes in AOD. Fixing the SSA value to 0.9, when the AOD increases from 0.2 to 1.0, the UV radiation decreases from 21.16 W/m2 to 12.64 W/m2 at 12:00; when AOD is maintained at 0.64, the SSA increases from 0.7 to 0.95, and the UV radiation increases from 14.55 W/m2 to 19.91 W/m2. The average annual attenuation rates of ultraviolet radiation by aerosols and clouds from 2005 to 2020 are 30.64% and 40.22%, respectively; the monthly averaged attenuation rates are 30.48% and 42.04%, respectively; and the daily averaged attenuation rates are 31.02% and 50.45%, respectively.
Renewed Concept of Mastoid Cavity Obliteration with the Use of Temporoparietal Fascial Flap Injected by Injectable Platelet-Rich Fibrin after Subtotal Petrosectomy for Cochlear Implant Patients
Authors: Zwierz Aleksander , Masna Krystyna , Burduk Paweł , Hackenberg Stephan , Scheich Matthias
Published: March 2024

Background: The subtotal petrosectomy procedure may be useful for cochlear implantation in selected patient groups. Although it is highly effective, complications can arise, which may have economic implications for the patient due to the high cost of the device. Therefore, several authors have attempted to identify the most effective concept for obliteration. Methods: We present a pilot descriptive study of application techniques for obliterating cavities after subtotal petrosectomy using a temporoparietal fascial flap (TPFF) modified with injectable platelet-rich fibrin (IPRF+) for three cochlear implant (CI) patients. Results: Our concept preserves important anatomical structures, such as the temporalis muscle, which covers the CI receiver–stimulator. Injection of IPRF+ also increases the available tissue volume for obliteration and enhances its anti-inflammatory and regenerative potential. Conclusions: To the best of our knowledge, the use of TPFF for filling the cavity has not been adopted for CI with SP and for blind sac closure. Our literature review and our experience with this small group of patients suggest that this procedure, when combined with IPRF+ injections, may reduce the risk of potential infection in the obliterated cavity, particularly when used with CI. This technique is applicable only in cases when the surgeons are convinced that the middle ear cavity is purged of cholesteatoma.
Four Families of Summation Formulas for 4F3(1) with Application
Authors: Kumar Belakavadi Radhakrishna Srivatsa , Rathie Arjun K. , Choi Junesang
Published: March 2024

A collection of functions organized according to their indexing based on non-negative integers is grouped by the common factor of fixed integer N. This grouping results in a summation of N series, each consisting of functions partitioned according to this modulo N rule. Notably, when N is equal to two, the functions in the series are divided into two subseries: one containing even-indexed functions and the other containing odd-indexed functions. This partitioning technique is widely utilized in the mathematical literature and finds applications in various contexts, such as in the theory of hypergeometric series. In this paper, we employ this partitioning technique to establish four distinct families of summation formulas for F34(1) hypergeometric series. Subsequently, we leverage these summation formulas to introduce eight categories of integral formulas. These integrals feature compositions of Beta function-type integrands and F23(x) hypergeometric functions. Additionally, we highlight that our primary summation formulas can be used to derive some well-known summation results.
Iron Dysregulation in Alzheimer’s Disease: LA-ICP-MS Bioimaging of the Distribution of Iron and Ferroportin in the CA1 Region of the Human Hippocampus
Authors: Junceda Susana , Cruz-Alonso María , Fernandez Beatriz , Pereiro Rosario , Martínez-Pinilla Eva , Navarro Ana
Published: March 2024

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by cognitive decline and neuropathological hallmarks, including β-amyloid (Aβ) plaques, Tau tangles, synaptic dysfunction and neurodegeneration. Emerging evidence suggests that abnormal iron (Fe) metabolism plays a role in AD pathogenesis, but the precise spatial distribution of the Fe and its transporters, such as ferroportin (FPN), within affected brain regions remains poorly understood. This study investigates the distribution of Fe and FPN in the CA1 region of the human hippocampus in AD patients with a micrometer lateral resolution using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). For this purpose, we visualized and quantified Fe and FPN in three separated CA1 layers: stratum molecular–radial (SMR), stratum pyramidal (SP) and stratum oriens (SO). Additionally, chromogenic immunohistochemistry was used to examine the distribution and colocalization with Tau and Aβ proteins. The results show that Fe accumulation was significantly higher in AD brains, particularly in SMR and SO. However, FPN did not present significantly changes in AD, although it showed a non-uniform distribution across CA1 layers, with elevated levels in SP and SO. Interestingly, minimal overlap was observed between Fe and FPN signals, and none between Fe and areas rich in neurofibrillary tangles (NFTs) or neuritic plaques (NP). In conclusion, the lack of correlation between Fe and FPN signals suggests complex regulatory mechanisms in AD Fe metabolism and deposition. These findings highlight the complexity of Fe dysregulation in AD and its potential role in disease progression.
An Updated Review of Recent Applications and Perspectives of Hydrogen Production from Biomass by Fermentation: A Comprehensive Analysis
Authors: Dari Dayana Nascimento , Freitas Isabelly Silveira , Aires Francisco Izaias da Silva , Melo Rafael Leandro Fernandes , dos Santos Kaiany Moreira , da Silva Sousa Patrick , Gonçalves de Sousa Junior Paulo , Luthierre Gama Cavalcante Antônio , Neto Francisco Simão , da Silva Jessica Lopes , Carlos de Castro Érico , Santos Alexandre Valdilane , da S. Lima Ana M. , Serpa Juliana de França , Souza Maria C. M. de , Santos José C. S. dos
Published: March 2024

Fermentation is an oxygen-free biological process that produces hydrogen, a clean, renewable energy source with the potential to power a low-carbon economy. Bibliometric analysis is crucial in academic research to evaluate scientific production, identify trends and contributors, and map the development of a field, providing valuable information to guide researchers and promote scientific innovation. This review provides an advanced bibliometric analysis and a future perspective on fermentation for hydrogen production. By searching WoS, we evaluated and refined 62,087 articles to 4493 articles. This allowed us to identify the most important journals, countries, institutions, and authors in the field. In addition, the ten most cited articles and the dominant research areas were identified. A keyword analysis revealed five research clusters that illustrate where research is progressing. The outlook indicates that a deeper understanding of microbiology and support from energy policy will drive the development of hydrogen from fermentation.
Termite Microbial Symbiosis as a Model for Innovative Design of Lignocellulosic Future Biorefinery: Current Paradigms and Future Perspectives
Authors: Dar Mudasir A. , Xie Rongrong , Zabed Hossain M. , Ali Shehbaz , Zhu Daochen , Sun Jianzhong
Published: March 2024

The hunt for renewable and alternative fuels has driven research towards the biological conversion of lignocellulosic biomass (LCB) into biofuels, including bioethanol and biohydrogen. Among the natural biomass utilization systems (NBUS), termites represent a unique and easy-to-access model system to study host–microbe interactions towards lignocellulose bioconversion/valorization. Termites have gained significant interest due to their highly efficient lignocellulolytic systems. The wood-feeding termites apply a unique and stepwise process for the hydrolysis of lignin, hemicellulose, and cellulose via biocatalytic processes; therefore, mimicking their digestive metabolism and physiochemical gut environments might lay the foundation for an innovative design of nature-inspired biotechnology. This review highlights the gut system of termites, particularly the wood-feeding species, as a unique model for future biorefinery. The gut system of termites is a treasure-trove for prospecting novel microbial species, including protists, bacteria, and fungi, having higher biocatalytic efficiencies and biotechnological potentials. The significance of potential bacteria and fungi for harnessing the enzymes appropriate for lignocellulosic biorefinery is also discussed. Termite digestomes are rich sources of lignocellulases and related enzymes that could be utilized in various industrial processes and biomass-related applications. Consideration of the host and symbiont as a single functioning unit will be one of the most crucial strategies to expedite developments in termite-modeled biotechnology in the future.
Corneal Sub-Basal Nerve Plexus Regeneration Pattern following Implantable Collamer Lens Implantation for Myopia: A Prospective Longitudinal In Vivo Confocal Microscopy Study
Authors: Wei Qiaoling , Ding Xuan , Chang Weiteng , Zhou Xianjin , Jiang Rui , Zhou Xingtao , Yu Zhiqiang
Published: March 2024

Implantable Collamer Lens (ICL) surgery has increasingly been adopted for myopia correction in recent decades. This study, employing in vivo confocal microscopy (IVCM), aimed to assess the impact of corneal incision during ICL surgery on the corneal sub-basal nerve plexus (SNP) and adjacent immune dendritiform cells (DCs). In this longitudinal study, eyes from 53 patients undergoing ICL surgery were assessed preoperatively and postoperatively over a twelve-month period. Quantification of seven SNP parameters was performed using ACCMetrics V.2 software. Ultimately, the final analysis was restricted to one eye from each of the 37 patients who completed a minimum of three months’ postoperative follow-up. Preoperative investigations revealed a positive correlation of DC density with patient age and a negative association with corneal nerve fiber density (CNFD). Additionally, both DCs and CNFD were positively linked to spherical equivalent refraction (SER) and inversely related to axial length (AL). Intriguingly, preoperative DC density demonstrated an indirect relationship with both baseline and postoperative CNFD changes. Post-surgery, an initial surge in DC density was observed, which normalized subsequently. Meanwhile, parameters like CNFD, corneal nerve fiber length (CNFL), and corneal nerve fractal dimension (CNFrD) initially showed a decline following surgery. However, at one-year follow-up, CNFL and CNFrD displayed significant recovery, while CNFD did not return to its baseline level. This study thus delineates the regeneration pattern of SNP and alterations in DC density post-ICL surgery, highlighting that CNFD in the central cornea does not completely revert to preoperative levels within a year. Given these findings, practitioners are advised to exercise caution in older patients, those with high myopia, or elevated preoperative DCs who may undergo delayed SNP regeneration.
Ferroptosis in Cardiovascular Disease and Cardiomyopathies: Therapeutic Implications of Glutathione and Iron Chelating Agents
Authors: Dawi John , Affa Scarlet , Gonzalez Edgar , Misakyan Yura , Nikoghosyan David , Hajjar Karim , Kades Samuel , Fardeheb Sabrina , Mirzoyan Hayk , Venketaraman Vishwanath
Published: March 2024

This review explores ferroptosis, a form of regulated cell death reliant on iron-induced phospholipid peroxidation, in diverse physiological and pathological contexts, including neurodegenerative disorders, and ischemia-reperfusion. In the realm of cardiovascular diseases, it significantly contributes to cardiomyopathies, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy. Ferroptosis involves intricate interactions within cellular iron metabolism, lipid peroxidation, and the balance between polyunsaturated and monounsaturated fatty acids. Molecularly, factors like p53 and NRF2 impact cellular susceptibility to ferroptosis under oxidative stress. Understanding ferroptosis is vital in cardiomyopathies, where cardiac myocytes heavily depend on aerobic respiration, with iron playing a pivotal role. Dysregulation of the antioxidant enzyme GPX4 is linked to cardiomyopathies, emphasizing its significance. Ferroptosis’s role in myocardial ischemia-reperfusion injury, exacerbated in diabetes, underscores its relevance in cardiovascular conditions. This review explores the connection between ferroptosis, the NRF2 pathway, and atherosclerosis, emphasizing their roles in protecting cells from oxidative stress and maintaining iron balance. It discusses the use of iron chelating agents in managing iron overload conditions, with associated benefits and challenges. Finally, it highlights the importance of exploring therapeutic strategies that enhance the glutathione (GSH) system and the potential of natural compounds like quercetin, terpenoids, and phenolic acids in reducing oxidative stress.
Low-Cost Arduino Reverse Transcriptase Loop-Mediated Isothermal Amplification (RT-LAMP) for Sensitive Nucleic Acid Detection
Authors: Camargo Bruno Dias , Cassaboni Stracke Mateus , Soligo Sanchuki Heloisa Bruna , de Oliveira Viviane Klassen , Ancelmo Hellen Cristina , Mozaner Bordin Dayanne , Klerynton Marchini Fabricio , Ribeiro Viana Emilson , Blanes Lucas
Published: March 2024

This work presents a low-cost transcription loop-mediated isothermal amplification (RT-LAMP) instrument for nucleic acid detection, employing an Arduino Nano microcontroller. The cooling system includes customized printed circuit boards (PCBs) that serve as electrical resistors and incorporate fans. An aluminum block is designed to accommodate eight vials. The system also includes two PCB heaters—one for sample heating and the other for vial lid heating to prevent condensation. The color detection system comprises a TCS3200 color 8-sensor array coupled to one side of the aluminum heater body and a white 8-LED array coupled to the other side, controlled by two Multiplexer/Demultiplexer devices. LED light passes through the sample, reaching the color sensor and conveying color information crucial for detection. The top board is maintained at 110 ± 2 °C, while the bottom board is held at 65 ± 0.5 °C throughout the RT-LAMP assay. Validation tests successfully demonstrated the efficacy of the colorimetric RT-LAMP reactions using SARS-CoV-2 RNA amplification as a sample viability test, achieving 100% sensitivity and 97.3% specificity with 66 clinical samples. Our instrument offers a cost-effective (USD 100) solution with automated result interpretation and superior sensitivity compared to visual inspection. While the prototype was tested with SARS-CoV-2 RNA samples, its versatility extends to detecting other pathogens using alternative primers, showcasing its potential for broader applications in biosensing.
Determinants of the Quality of Life in Patients with Drug-Resistant Temporal Lobe Epilepsy: A Comparison of the Results before and after Surgery
Authors: Bala Aleksandra , Olejnik Agnieszka , Kułak Michał , Rysz Andrzej , Dziedzic Tomasz , Nowak Arkadiusz , Marchel Andrzej , Kunert Przemysław
Published: March 2024

Drug-resistant temporal lobe epilepsy is associated with a reduction in the quality of life of patients. The aim of this study was to compare the quality of life before and after the surgical treatment of epilepsy and to assess factors that may affect the well-being of patients after surgery. The study involved 168 patients with drug-resistant temporal lobe epilepsy. All of them were examined twice: once before and again one year after surgery. Two questionnaires were used in the study: the Quality of Life in Epilepsy Inventory-Patient-Weighted and Hospital Anxiety and Depression Scale and one that collected data on selected demographic and clinical variables. The results showed that patients scored significantly higher in quality of life and lower in depression and anxiety after surgery; however, this only applied to patients with a good outcome of treatment (Engel Class I and Class II). Patients with an unfavorable outcome of surgical treatment (Engel Class III and Class IV) achieved significantly worse results in all examined variables. Correlational analysis showed a relationship between select aspects of quality of life and the level of depression and anxiety, as well as the frequency of seizures and age at epilepsy onset. There was no significant relationship with age, sex, education, or number of prescribed antiepileptic drugs. The study confirms the significant relationship between the quality of life and the effectiveness of surgical treatment, indicating the relationship between patients’ well-being and selected clinical indicators.
The Associations of Exposome Score with Various Domains of Psychopathology: A Network Analysis in a Non-Clinical Sample
Authors: Rejek Maksymilian , Misiak Błażej
Published: March 2024

Background: The intricate correlation between environmental exposures and mental health outcomes is increasingly acknowledged in psychiatric research. This study investigated the relationship between cumulative environmental risk factors, as represented by the exposome score (ES), and various domains of psychopathology within a non-clinical sample using a network analysis. Methods: We recruited 1100 participants (aged 18–35 years, 51.4% females) via a computer-assisted web interview, assessing psychopathological symptoms using standardized questionnaires. Environmental exposures, including season of birth, obstetric complications, advanced paternal age, childhood trauma, cannabis use, and urban upbringing, were self-reported to calculate the ES. Results: A network analysis revealed significant associations of the ES with psychotic-like experiences (PLEs) (weight = 0.113), manic (weight = 0.072), and attention-deficit/hyperactivity disorder symptoms (weight = 0.062). These connections did not differ significantly with respect to their weights. Depressive symptoms had the highest centrality and predictability. The mean predictability across all nodes included in the network was 0.344. Conclusions: These findings underscore the transdiagnostic nature of environmental exposures, aligning with previous research indicating broad associations between the ES and various facets of psychopathology. Our results suggest that the ES may not specifically correlate with PLEs but may indicate the risk of a broader psychopathology.