bluuebunny/crossref_metadata_2025 huggingface dataset:
Loss of endothelial cytochrome P450 reductase induces vascular dysfunction in mice
Authors:   , Malacarne Pedro Felipe
Published: March 2024

Aim The cytochrome P450 reductase (POR) along with the cytochrome P450 enzymes (CYP) are responsible for the metabolism of a multitude of metabolites important for the maintenance of tissue function. Defects in this system have been associated with cardiovascular diseases. These enzymes are known to produce vasoactive lipids that modulate vascular tone. The aim of this study was to identify the consequence of a loss in endothelial POR for vascular function. Methods and Results To identify the endothelial contribution of the POR/CYP450 system to vascular function, we generated an endothelial-specific, tamoxifen-inducible POR knockout mouse (ecPOR-/-). Under basal condition ecPOR-/- already exhibited endothelial dysfunction in aorta and mesenteric vessels (acetylcholine-dependent relaxation, LogEC50 -7.6M for CTR vs. -7.2M for ecPOR-/- in aorta) and lower nitric oxide levels in the plasma (CTR: 236.8 ±77.4; ecPOR-/- 182.8 ±34.1 nmol/L). This dysfunction was coupled to attenuated eNOS function detected by the heavy arginine assay and decreased eNOS phosphorylation on S1177. Furthermore, insulin-induced phosphorylation of the eNOS activator, AKT, was also attenuated in the aorta from ecPOR-/- mice as compared to control mice. CYP450-dependent EET production was lower in plasma, lung and aorta of ecPOR-/- mice and this was accompanied with increased levels of vasoconstriction prostanoids (lipidomics of aorta, plasma and lung freshly isolated from CTR and ecPOR-/- mice). MACE-RNAseq from these aortas also showed a significant increase in genes annotated to eicosanoid production. In an in vivo angiotensin II model, acute deletion of POR increased the blood pressure as measured by telemetry and tail cuff (137.4 ± 15.9 mmHg in WT; 152.1 ± 7.154 mmHg in ecPOR-/-). In a rescue experiment using the NSAID naproxen, the increase in blood pressure induced by deletion of endothelial POR was abolished. Conclusion Collectively, in endothelial cells POR regulates eNOS activity and orchestrates the metabolic fate of arachidonic acid towards the vessel dilating EETs and away from deleterious prostanoids. In the absence of POR this endothelial regulation is compromised leading to vascular dysfunction.
FACTORS AFFECTING CONSUMERS’ IMPULSE BUYING BEHAVIOUR FOR APPARELS:
Authors: Surabhi Agrawal  , Dr. Avinash Singh
Published: March 2024

Impulse buying behaviour is a significant factor as marketers try to tap this behavior of customers to boost sales. The aim of this research is to explore the factors that have an influence on consumers’ impulse buying behaviour for apparels. A self administered questionnaire developed from the literature was administered to 109 consumers. Data have been analysed by using SPSS 22 for correlation and regression. The resulted values for the construct store environment, sales promotion and person’s situation, show positive significant influences with impulse buying, whereas the construct product qualities and shopping enjoyment tendency have an adverse effect on impulse purchase. The study provides merchants, academics, and scholars with helpful knowledge into the impulse buying behavior of Indian buyers, as well as the implications for the management of retailers. This study was restricted to Uttar Pradesh customers and apparel just.
UNMASKING DECEPTION: FORENSIC ACCOUNTING'S INFLUENCE ON FRAUD REDUCTION IN INDIA'S BANKING INDUSTRY
Authors: Dr. Rajesh M Patel
Published: March 2024

The significance of forensic accounting in fraud reduction cannot be overstated, particularly in a complex financial landscape like India's banking industry. Forensic accounting serves as a crucial instrument in detecting, investigating, and preventing fraudulent activities that pose substantial threats to the integrity and stability of financial institutions. Through specialized techniques like data analysis, financial examination, and investigative methodologies, forensic accountants play a pivotal role in uncovering fraudulent schemes, tracing illicit financial transactions, and providing evidence for legal proceedings. This study delves into the critical role of forensic accounting in combating fraudulent activities within India's banking sector. With a focus on enhancing understanding and awareness, the research sets out three primary objectives. Firstly, it aims to investigate the current landscape of forensic accounting in India, exploring its methodologies, practices, and regulatory framework. Secondly, the study seeks to assess the level of awareness among bank managers regarding the efficacy of forensic accounting in reducing instances of fraud. Finally, it endeavours to analyse the relationship between the demographic profiles of bank managers—such as age, gender, and years of experience—and their awareness of forensic accounting's role in fraud reduction. Moreover, the findings of this study carry practical implications for various stakeholders, including policymakers, regulators, banking professionals, and industry participants. By gaining insights into the awareness levels of bank managers regarding forensic accounting and its efficacy in fraud reduction, policymakers and regulators can develop targeted interventions to enhance training, education, and awareness initiatives within the banking industry. The study's methodology involved interviews with 200 bank managers, allowing for a comprehensive assessment of the impact of forensic accounting on fraud reduction within India's banking industry.
EXPLORATORY ROLE OF COGNITIVE BEHAVIORAL FACTORS ON PSYCHOLOGICAL EMPOWERMENT AMONG YOUTH
Authors: Dr. Sudha Rathore  , Tavishi Limaye  , Kritika Bhair
Published: March 2024

An individual is said to be psychologically empowered when the individual has control and can make his/her own life choices, which is essential in present times. In this context, cognitive flexibility and self-control act as effective tools to regulate one’s urges, be motivated and regulate the available resources in the most effective way, so that the individual can make successful life decisions and achieve the goals, while on other hand perseverative negative thinking hampers an individual’s decision making and goal achievement, which is especially true in current times. Considering this aspect the purpose of the current study was to look at the connection between psychological empowerment, cognitive flexibility, perseverative thinking and self-control and to study the interaction of cognitive flexibility, perseverative thinking, and self-control concerning psychological empowerment in present times. Purposive sampling technique was used to select the sample. The study sample was university students of upper-middle and higher socioeconomic backgrounds aged between 18 and 25 years, from urban domicile. Product Moment Correlation and Regression analysis was administered to test the hypothesis. The result showed that the dimensions of psychological empowerment were significantly correlated with cognitive flexibility, self-control and perseverance, also the three variables of the study (cognitive flexibility, perseverative thinking, and self-control) significantly contributed variance in predicting psychological empowerment. This research implicates that there are clear potential benefits to delivering effective intervention for youth so that they can be taught ego depletion strategies which in turn leads to long term goal satisfaction.
EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF ARABICA COLD BREW AND ARABICA SPENT COFFEE GROUNDS ON STREPTOCOCCUS MITIS
Authors: Ariana Budhihartanto
Published: March 2024

Spent coffee grounds or coffee waste pose a growing environmental problem as it can harm the ecosystem by releasing greenhouse gases into the atmosphere during their decomposition process [1]. On the other hand, spent coffee ground extracts have been shown to contain polyphenols, trigonelline, phenolic acids, and melanoidins which show strong antibacterial activity toward Gram+ bacteria and yeast [2]. Given its activity towards Gram+ bacteria, this study seeks to find an alternative use of spent coffee grounds, aiming to mitigate their environmental impact. This research focuses on the investigation on whether arabica spent coffee grounds could be used as a natural alternative to iodine mouthwash solution, a commonly used product to kill dental plaque bacteria. Arabica coffee extract was prepared by a 24-hour cold brew procedure then spent coffee grounds extract was produced from the Arabica coffee waste. To obtain results, the antibacterial activity of both spent coffee grounds and coffee on S. mitis was analyzed using the well diffusion test and inhibition zones were measured and compared. The caffeine contents of the Arabica coffee grounds were quantified using HPLC. From our quantitative analysis, the spent arabica coffee grounds collected from the cold brew procedure consist of less caffeine, compared to that of the cold brew, but still showed antibacterial activity towards S. mitis. The inhibition zone of the spent coffee grounds was significantly lower than cold brew coffee but still comparable to iodine mouthwash solution. Our novel findings indicate that spent coffee grounds can be used as a natural antibacterial and an alternative to povidone-iodine mouthwash which leads to reduction of environmental harm from coffee waste.
પંચમહાલ જિલ્લામાં આવેલ ઐતિહાસિક સ્થળો
Authors: રામી કિશોરકુમાર જેન્તીભાઈ  , ડૉ. દક્ષા એમ. પટેલ
Published: March 2024

પંચમહાલ જિલ્લામાં આવેલ ઐતિહાસિક સ્થળો
DEVELOPMENT OF GRADE LEVEL ASSESSMENT TOOL IN SOCIAL SCIENCE (GLAT-SS) FOR GRADE VII &VIII BASED ON KARNATAKA STATE EDUCATION BOARD FOR TYPICALLY DEVELOPING CHILDREN AND CHILDREN WITH HEARING IMPAIRMENT
Authors: Dr. Alok Kumar Upadhyay  , Mr. Raj Kumar R.  , Ms. Sowmya N. S.  , Mr. Deepak Kumar
Published: March 2024

The aim of the present study was to develop the Grade Level Assessment Tool in Social Science (GLAT-SS) for the Karnataka State Education Board's grades VII and VIII employing a survey design. The study's target population consisted of 29 schools spread across five districts in Karnataka. Purposive sampling technique was employed to select participants for the study.In the study, a total 866 typically developing children from five districts (Mysore, Chamarajnagar, Mandya, Bengaluru & Kalaburagi) of Karnataka State participated. For the pilot study, 100 typically developing children participated and 766 typically developing children studying in Grade VII & VIII from five districts of Karnataka State participated in the final data collection, among them 263 students (154 English and 109 Kannada) were from Mysuru district; 82 students (English medium) were from Chamrajnagara district; 12 students (English medium) from Mandya district; and 32 students (25 English and 07 Kannada) were from Bengaluru district participated.

The final analysis and interpretations of results reveal that There is significant difference found in performance of Grade Level Assessment Test (GLAT-SS) in Social Science between Typically Developing students and students with Hearing Impairment grade VII & VIII students studying in English Medium as well as Kannada Medium.
ROLE OF STUDENTS' AND TEACHERS' ASSOCIATIONS OF GAUHATI UNIVERSITY IN GOVERNANCE
Authors: Dr. Marie Kalita
Published: March 2024

This paper focuses on Students' and Teachers' Associations of Gauhati University and their problems, democratic agitations, demands, fulfillments etc. in the greater interests of students and teachers. Since its establishment in January, 1948, Gauhati University, considered to be the mother university of the entire North East has been serving as a seat of Higher Education for this region till the late 80s. There are lots of problems due to the changing scenario of our country in political and economic affairs and also due to liberalization, globalization and privatization which needs to be addressed. Gauhati University has also borne the brunt of such impacts.

An attempt has been made in this paper to find out the demands of the students' and teachers' Associations of Gauhati University and also to see how they are acting as pressure groups for the fulfillment of their just demands. A descriptive survey method has been adopted and data collected by first hand studies by conducting interviews with the office bearers of these associations and also the authorities for the fulfillment of their just demands.
CREATIVITY AMONG COLLEGE GOING STUDENTS IN RANCHI TOWN
Authors: Kalawati Jaiswal  , Safeena Naaz
Published: March 2024

This research paper investigates cognitive disparities among college-going students in Ranchi Town, focusing on fluency, flexibility, and originality across various demographic categories. The study analyzes mean scores and employs t-tests to discern significant differences within the population. The findings indicate that, while there is no significant difference in fluency between boys and girls, a noteworthy distinction emerges between tribal and non-tribal college students. These results suggest the importance of tailoring educational interventions to meet the diverse needs of students based on demographic differences. However, no significant differences were observed in flexibility and originality between boys and girls or among tribal and non-tribal college-going students. The study contributes valuable insights to educational research, emphasizing the necessity for nuanced approaches to address cognitive disparities and fostering an inclusive learning environment. Further research is recommended to delve deeper into the intricate factors influencing cognitive abilities within different demographic groups.
EXPLORING PREFERRED STYLES OF LEARNING AND TEACHING AMONG COLLEGE STUDENTS IN VIEW OF NEW EDUCATION POLICY 2020
Authors: Bhadrapriya T. N.  , Lydia Biju  , Raphael Jude  , Neha Jimmy
Published: March 2024

With the advent of New Education Policy (NEP) 2020, India has a vision to transform its education system by shifting its attention to learner-centred approach for holistic understanding of subjects using different styles of teaching and learning like activity-based learning and teaching in one’s own mother tongue. Students use different modalities to perceive, understand and learn different subjects taught in class. Based on the modalities used (visual, auditory or tactile), students may develop visual, auditory or kinesthetic styles of learning. This study aimed to identify learning styles and preferred teaching styles of current college students between the ages 18-25. In addition, the study seeks to understand the preferred teaching style opted by students. A comparison in terms gender, and educational level were made. Through convenient sampling technique willing participants were administered Barsch Learning Styles Inventory (Barsch, J. 1980) and were asked to rank various teaching styles like visual, auditory and kinesthetic in the order of their preference. Appropriate statistics were used for data analysis. The results of the study showed that college student’s preferences for learning styles were not influenced by gender or educational level. The order of preference of students in terms of preferred teaching style was found to be visual followed by auditory followed by tactile.
MEDIATION OF TRIGUNA DOMINANCE BETWEEN RATIONALITY AND COPING HUMOR
Authors: Dr. Sudha Rathore  , Manvee Goyal
Published: March 2024

Since the emergence of positive psychology, researchers are trying to establish relationships among positive psychological variables, individual characteristics and environmental factors, in order to find approaches to enhance well-being and psychological health.

In this regard, researchers have been adopting Eastern or Western perspective. Researches with Western perspective have always been in the forefront, while Eastern perspectives, although being age-old systems, have emerged in the spotlight in recent decades. These two perspectives well-define cultural differences while also accounting for individual differences, therefore, considered important to study.

Despite large number of studies on positive psychological variables, there is a need for establishing the role of cognitive aspects in positive psychological variables, furthermore so, in the light of Eastern perspective.

Thus, the present study aimed to explore the mediational role of Triguna dominance in relationship of Rationality with Coping Humor. The study sample consisted of 100 mid-adults (40-65 years).

Significant results of correlation and regression motivated to perform mediational analysis. The relationship of Rationality with Coping Humor was found to be 0.12 and 0.22 points higher as mediated by Rajas and Tamas guna respectively. Satva guna had no mediational role in their relationship.

Coping humor is a relatively new variable in positive psychology with limited research and theoretical bases. The results of the study can guide researchers in the exploration of the variable and development of the theories and models based on integrated research findings, furthermore so, with an Eastern perspective of Triguna. The study can be implied to various psychological fields, like counselling, rehabilitation psychology, health psychology, and others, to develop interventions and techniques to increase Rationality, Coping humor, and Satva guna while decreasing Rajas and Tamas guna to boost mental health and well-being.
SACRED GROVES: A BASTION OF BIODIVERSITY AND CULTURAL HERITAGE
Authors: Mehtab Singh Rathore
Published: March 2024

Sacred groves, also known as sacred forests, are revered natural areas that hold deep spiritual and cultural significance for indigenous communities around the world. These enclaves of biodiversity have played a crucial role in conserving natural ecosystems, protecting endangered species, and preserving traditional knowledge and practices for centuries.

This paper explores the multifaceted significance of sacred groves, highlighting their contributions to biodiversity conservation, cultural heritage preservation, and the well-being of local communities. It delves into the intricate relationship between indigenous communities and their sacred groves, emphasizing the interconnectedness of nature, spirituality, and culture.

Drawing upon case studies from diverse regions, the paper showcases the tangible benefits of sacred groves in safeguarding threatened flora and fauna, maintaining ecosystem health, and providing ecological services such as soil and water conservation. It also underscores the cultural significance of these sites as repositories of traditional knowledge, sacred rituals, and artistic expressions.

The paper concludes by emphasizing the urgent need to recognize and protect sacred groves as invaluable assets for both biodiversity conservation and cultural heritage preservation. It advocates for collaborative approaches that empower indigenous communities in safeguarding their sacred groves and integrating their traditional knowledge into conservation efforts.
Machine learning rather than trial and error to close morphodynamical tuneable parameters: Application to a two-phase/two-layer model
Authors: Meurice Robin , Soares-Frazão Sandra
Published: March 2024

Physics-based numerical models often depend on several parameters to close. Some of them can be expressed using established theoretical or empirical closure formulations. However, some others aggregate complex physical processes and are hence left as tuneable parameters, and can only be calibrated by trial and error. Yet, calibration data are not always available to do so, which prevents these models from being applied to wide ranges of laboratory or river flows. We hence propose a machine learning-based methodology to close any group of unclosed and correlated parameters, applied here to a two-phase/two-layer (2P2L) morphodynamical model. The methodology combines a numerical experiment with a known theoretical solution and machine learning. It is applied to the considered model to close two friction parameters for which generalizable and vastly acknowledged closure formulations lack in the literature. The resulting hybrid model, combining the original 2P2L model and the closure models, is tested against two laboratory dam break test cases. Despite excessive smoothness and underestimation of the concentration in sediment, the hybrid model performed similarly to other models from the literature requiring trial and error calibration and showed high stability and accuracy regarding the estimation of the water-sediment mixture's inertia.
Remediation of toluidine blue O dye from aqueous solution using surface functionalized magnetite nanoparticles
Authors: Jangra Arti , Kumar Ramesh , Singh Devender , Kumar Harish , Kumar Jai , Kumar Parvin , Kumar Suresh
Published: March 2024

In the current study, tannic acid-functionalized iron oxide nanoparticles have been synthesized using a cost-effective co-precipitation method and subsequently characterized using various instrumentation techniques such as Fourier transform infrared spectroscopy, X-ray diffractometer, field emission scanning electron microscopy, and thermal gravimetric analysis. Further, these surface-modified magnetite nanoparticles have been used for the adsorption of toluidine dye from an aqueous solution. The adsorption process was accompanied using batch procedure, and influences of several factors such as adsorbent dose, contact time, pH, temperature, and initial concentration of adsorbate were inspected concurrently. The maximum adsorption capacity of tannic acid-functionalized magnetite nanoparticles was found to be 50.68 mg/g. The adsorption process was observed to follow the Temkin isotherm model, whereas the kinetic study was well described by pseudo-second order. The thermodynamic study revealed the adsorption process to be endothermic and spontaneous in nature with a high degree of freedom between adsorbent and adsorbate. Therefore, the study indicated that the tannic acid-functionalized magnetite nanoparticles have promising adsorption capability and can be used as an excellent adsorbent for the removal of toluidine blue O dye from the aqueous solution.
Novo Ensino Médio
Authors: Olmedo Alessandra dos Santos , Silva Erica Cristina da , Gondin Cristiane Miranda Magalhães , Machado Vera de Mattos
Published: March 2024

A educação está intimamente ligada à política e à cultura, e de tal modo, o currículo escolar não pode ou não deve ser compreendido apenas como um conjunto neutro de conhecimentos. Assim, para atender as mudanças curriculares, os materiais didáticos são alterados, principalmente tratando-se da Reforma do Ensino Médio (EM) e da implantação da Base Nacional Comum Curricular (BNCC). O objetivo deste relato de experiência é descrever a experiência da escolha dos livros didáticos pela coordenação pedagógica do PNLD do EM durante a pandemia da Covid-19, em uma escola pública estadual de Mato Grosso do Sul (Brasil). Resultou-se nas seguintes considerações: diante das incertezas do novo currículo e da redução da carga horária, os professores escolheram os livros didáticos mediados pela coordenação pedagógica. Consideramos preocupante o silenciamento das disciplinas de Química, Física e Biologia com a consequente redução da carga horária.
Discovery of Multiple Effects of Reactive Oxygen Species on Lung
Adenocarcinoma at the Single-cell and Bulk Tissue Levels
Authors: Zhang Cong , Liu Bin , Xie Xianjin , Lu Degan
Published: March 2024

Background::

Reactive oxygen species (ROS) are potential targets for treating
malignant tumors.

Aims::

The aim of this study was to probe into the mechanisms of disease development and treatment
in lung adenocarcinoma (LUAD).

Objective::

This study investigated the impact of ROS on the progression of LUAD at different
transcriptomic levels and analyzed key molecules involved in the regulation of LUAD.

Methods::

Single-cell RNA-seq (scRNA-seq) data of LUAD were clustered and annotated to determine
cell types. Scissor cells based on LUAD bulk transcriptome and epithelial scRNA-seq data
were used to classify subsets associated with ROS phenotypes. Least absolute shrinkage and selection
operator (LASSO) and stepwise multivariate regression analyses were performed between the
Scissor-positive and Scissor-negative epithelial cells to select key differentially expressed genes
(DEGs) for developing a ROS-related signature.

Results::

The ROS score was significantly negatively correlated with the overall survival (OS) of
LUAD. Seven cell types from the LUAD tissues were identified. The ROS-related gene signature
was significantly correlated with metabolism, tumor microenvironment (TME) indicators, and the
half-maximal inhibitory concentration (IC50) values of 10 drugs. The gene signature was verified
as an independent indicator for LUAD prognosis.

Conclusion::

The current study provided novel insights into the impact of ROS on LUAD pathology
at both single-cell and bulk-tissue levels, facilitating the prognostic evaluation and drug therapy
development for patients with LUAD.
Biofilm Formation in Mycobacterial Genus; Mechanism of Biofilm Formation and Anti-Mycobacterial Biofilm Agents
Authors: Nasrollahian Sina , Pourmoshtagh Hassan , Sabour Sahar , Hadi Nahal , Azimi Taher , Soleiman-Meigooni Saeed
Published: March 2024

Mycobacterium tuberculosis, Mycobacterium leprae, and non-tuberculous mycobacteria
(NTM) are among the most significant human pathogens within the Mycobacterium genus.
These pathogens can infect people who come into contact with biomaterials or have chronic
illnesses. A characteristic pathogenic trait of mycobacteria is the development of biofilms,
which involves several molecules, such as the GroEL1 chaperone, glycopeptidolipids, and
shorter-chain mycolic acids. Bacterial behavior is influenced by nutrients, ions, and carbon
sources, which also play a regulatory role in biofilm development. Compared to their planktonic
phase, mycobacterial biofilms are more resilient to environmental stresses and disinfectants.
Mycobacteria that produce biofilms have been found in several environmental studies, particularly
in water systems. NTM can cause respiratory problems in individuals with underlying illnesses
such as cystic fibrosis, bronchiectasis, and old tuberculosis scars. Mycobacteria that grow
slowly, like those in the Mycobacterium avium complex (MAC), or rapidly, like Mycobacterium
abscessus, can be pathogens. Infections related to biomaterials represent a significant category
of biofilm-associated infections, with rapidly growing mycobacteria being the most frequently
identified organisms. A biofilm produced by M. tuberculosis can contribute to caseous necrosis
and cavity formation in lung tissue. Additionally, M. tuberculosis forms biofilms on clinical
biomaterials. Biofilm formation is a major contributor to antimicrobial resistance, providing
defense against drugs that would typically be effective against these bacteria in their planktonic
state. The antibiotic resistance of biofilm-forming microbes may render therapy ineffective, necessitating
the physical removal of biofilms to cure the infection. Recently, new approaches
have been developed with potential anti-biofilm compounds to increase treatment effectiveness.
Understanding biofilms is crucial for the appropriate treatment of various NTM diseases, and the
recent discovery of M. tuberculosis biofilms has opened up a new field of study. This review
focuses on the biofilm formation of the Mycobacterial genus, the mechanisms of biofilm formation,
and anti-mycobacterial biofilm agents.
Immunomodulatory Plant Natural Products as Therapeutics against
Inflammatory Skin Diseases
Authors: Sampath Kumar Nikhila , Reddy Navaneetha , Kumar Halmuthur , Vemireddy Sravanthi
Published: March 2024

Frequently occurring inflammatory skin conditions such as psoriasis, dermatitis, acne,
including skin cancer, wounds and other disorders arising out of premature skin aging, deteriorate
skin health and adversely impact human life. Even though several synthetic compounds have
evolved for treating these skin conditions, natural-product-based therapeutics are gaining popularity
with growing evidence of their efficacy and safety for treating skin disorders. Many of these inflammatory
skin diseases have underlying disturbances in our immune system and immunomodulatory
natural products provide solutions for their effective treatment and aid in understanding the
underlying mechanism of such inflammatory skin conditions. Based on this premise, the present
review summarizes the possible application of plant-derived immunomodulatory compositions
and single molecules for treating inflammatory skin conditions. In vitro, in vivo and mechanistic
studies reported the application of selected plant-derived natural products for the treatment of inflammatory
skin disorders including, cancer and infections.

:

Several online databases including PubMed, Google Scholar, and Science Direct have been
searched for gathering the information covered in this review. Empirical studies demonstrated that
most of these natural compounds exhibited therapeutic properties through their immunomodulatory
and anti-inflammatory potential supplemented often with anti-microbial, anti-neoplastic, and anti-
oxidant activities. Overall, plant-based natural products discussed here are capable of modulating
the immune system to minimize or completely suppress the pro-inflammatory markers, scavenge
free radicals (ROS), prevent bacteria, fungal, and virus-derived skin infections and often
regress skin cancer through the induction of apoptosis. The challenges and opportunities associated
with the application of plant-based immunomodulators for skin applications and their safety
considerations are also discussed here. The present study indicated that immunomodulatory plant
natural products being biologically validated ligands against various biological targets manifested
in inflammatory skin diseases, offer an effective, safe and affordable treatment for such disorders
affecting skin health. However, further clinical evaluations are needed to substantiate these findings.
Design, Synthesis, Antitumor Activity Evaluation, and Molecular Dynamics
Simulation of Some 2-Aminopyrazine Derivatives
Authors: Cui Hangrui , Zhang Ruifeng , Xiong Xin , Cui Zhiwen , Min Zhijian , Liu Jinglong , Li Xunping , Min Zhenli
Published: March 2024

Objective::

Cancer poses a great threat to human health, and effective drugs to treat it
are always needed. Several compounds containing a 2-aminopyrazine framework have been
identified as antitumor agents with SHP2 inhibition activities. This current work aimed to search
for more potent novel compounds possessing a 2-aminopyrazine moiety with antitumor activities.

Methods::

A series of 12 novel 2-aminopyrazine derivatives was synthesized, and their structures
were confirmed by spectroscopic techniques. The inhibitory activities of all the synthesized
compounds against MDA-MB-231 and H1975 cancer cell lines were evaluated by an
MTT assay. The most potent compound 3e was analyzed by flow cytometry. Subsequently,
computational studies were performed to investigate the possible antitumor mechanisms of
compound 3e.

Results::

The results indicated that compound 3e exhibited potent antitumor activities with IC50
values of 11.84±0.83μM against H1975 cells and 5.66±2.39μM against MDA-MB-231 cells,
which were more potent than the SHP2 inhibitor GS493 (IC50 = 19.08±1.01 μM against H1975
cells and IC50 = 25.02±1.47 μM against MDA-MB-231 cells). Further analysis by flow cytometry
demonstrated that compound 3e induced cell apoptosis in H1975 cells. The results of the
molecular docking and MD simulations, including RMSD, RMSF, PCA, DCCM and binding
energy and decomposition analyses, revealed that compound 3e probably selectively inhibited
SHP2.

Conclusion::

A new compound having a 2-aminopyrazine substructure with potent inhibitory
activities against the H1975 and MDA-MB-231 cancer cells was obtained, meriting further investigation
as an antitumor drug.
Green Method Synthesis of Magnetic Nanoparticles and its Functionalized MNPs for Knoevenagel Condensation Reaction
Authors: Shekhanavar Raju , Khatavi Santosh Y , Kamanna Kantharaju
Published: March 2024

Background:

Knoevenagel condensation is an important C-C bond formation reaction
catalyzed by various homogeneous and heterogeneous acid-base catalysts.

Method:

The present work describes the eco-friendly preparation of magnetic nanoparticles Fe3O4
(MNPs) and its functionalization to Fe3O4@SiO2@SO3H. The prepared MNPs and their functionalized
materials were fully characterized by FT-IR, XRD, FE-SEM, HR-TEM, and VSM. Further
demonstrated application of these catalysts for the C-C bond formation reactions of Knoevenagel
condensation employing special aldehyde derivatives with malononitrile at room temperature gave
excellent product isolation.

Results:

The application of the prepared functionalized MNPs for the Knoevenagel condensation
was demonstrated by the reaction of various aryl/heterocyclic and cholesterol aldehyde with malononitrile
at room temperature stirring for about 30 min in ethanol solvent. The final product isolated
is confirmed by various spectroscopic techniques such as FT-IR, 1H-, & 13C-NMR, and mass spectrometry.
Furthermore, the selected compounds are screened for their photophysical properties, and
interestingly compound 3j showed good fluorescent properties.

Conclusion:

Overall the present work described a greener method preparation of MNPs, and its
functionalized employed as a heterogeneous catalyst for the Knoevenagel condensation of various
aryl/heterocyclic and cholesterol aldehyde with malononitrile. The method developed is simple,
easily separated catalyst by an external magnet, and recycled up to five cycles without any noticeable
change in the final product isolation. Further, the prepared derivatives screened for their photophysical
properties, and interestingly compound 3j showed good fluorescent properties.
Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep
Authors: Kumari Beena , Kumar Sunil , Kumar Kailey Sandeep , Kumar Manish
Published: March 2024

Unlock success in pharmaceutical exams with Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep. This guide is meticulously crafted to tackle the challenges of pharmaceutics exams through a diverse range of questions. It covers multiple choice questions, concise one-liners, and true/false statements, mirroring the formats commonly found in drug inspector, pharmacist, GPAT, nursing exams, and more.

Key Features:

Exam-Ready Questions: Prepare for a variety of medical exams with more than 2000 carefully curated questions.

Diverse Testing Formats: Master multiple choice, one-liner, and true/false questions for a well-rounded exam readiness.

Broad Assessment: Tailored for drug inspectors, pharmacists, GPAT aspirants, and other medical professionals.

Build Thinking Capabilities: Progress from simple to challenging questions, enhancing critical thinking skills.

This thorough guide empowers you to learn the key topics in pharmaceutics and navigate the most challenging questions in your exam prep journey.
Kriyakala in Ayurveda: Understanding disease progression for precise treatments
Authors: Neha Bishnoi  , Suman Meena  , Man Mohan Sharma
Published: March 2024

Ayurveda, an ancient wisdom, focuses on keeping healthy people healthy and healing those who are unwell. It does this by balancing Dosha (biological factors), Dhatu (body tissues), and Mala (waste). Shat Kriyakala is about understanding how a disease progresses. It helps figure out the right actions to fix dosha imbalances. Kriyakala is a mix of two words: Kriya, meaning the treatments like medicine, food, and habits that help fix dosha imbalances, and Kala, which shows the stage of a disease. Acharya Sushruta talked about six stages that tell us how a disease is developing in the body. This guides us on when to step in with treatment. Detecting diseases early means we can treat them more effectively and with less discomfort. This study aims to show how Shat Kriyakala is super useful in figuring out how diseases progress and how severe they might get. This concept is found in ancient texts. Kriyakala is like a guidebook. It tells us about diagnosis (figuring out what's wrong), prognosis (how the disease might go), and when to act. This helps prevent a disease from taking a strong hold in the body. Understanding Kriyakala helps us know when to step in to keep diseases from getting worse.
Fertility with Ayurveda - A Single Case Study on Treatment of Primary Infertility due to Tubal Blockage with Polycystic Ovarian Syndrome
Authors: Basanti Guru  , Payal Sindel
Published: March 2024

Infertility associated with Polycystic Ovarian Syndrome (PCOS) is a major cause of concern in the present generation among the reproductive age groups due to unhealthy lifestyles in the modern era. This is a case report of an infertile couple who had not been able to conceive for 4 yrs. The female was diagnosed with PCOS with left tubal blockage. The objective of the present treatment included Ayurvedic management of PCOS, ensuring regular ovulation and thereby helping to develop healthy pregnancy and successful childbirth. Based on Ayurvedic science this case was diagnosed as Vandhyatva (Infertility) due to Nashtartava (that can be related with Polycystic ovarian disease) And Tubal blockage that can be related with Artava Vaha Strotosangha. This research paper presents a case study of the effectiveness of a comprehensive Ayurvedic treatment approach involving Uttarbasti with Kasisadi Tail along with oral medicines i.e., Pushpadhanva Ras and Kanchnar Guggulu as major medications in the successful treatment of a primary infertility patient having history of Polycystic Ovarian Syndrome (PCOS) And Tubal blockage. In Ayurveda primary infertility can be correlated with Anapatya type of Vandhyatava and its causative factor PCOD can be correlated with Nashtaartava as per Sushrut and Pushpaghnijataharni as per Kashyap and tubal blockage as Sanga variant of Artavavaha Strotodushti. Treatment plan included both Shodhana (Purification) and Shamana (mitigation) therapies. The outcome of the Ayurvedic intervention was the conception of the patient within 1 year of treatment.
Role of Virechana and Neelakantha Rasa as Rasayana with Phalatrikadi Kwatha Anupana in Madhumeha (DM2) - A Single Case Study
Authors: Narasareddy  , Madhava Diggavi  , Fareeda Begum Shaikh  , Ramaling Hugar
Published: March 2024

Madumeha is a progressive both Avaranajanya and Dhatukshayajanya Vyadhi[1] it is correlated with diabetes mellitus, with the involvement of Tridosha. Diabetes mellitus is a metabolic, autoimmune, stress induced impaired hyperglycemia. It is due to either deficiency of insulin or combination of insulin resistance and inadequate insulin secretion. Virechana and Rasarasayana Yogas are stated as the best in Madhumeha. In the present study Virechana was selected. For Deepana Pachana, Abhayadi Kwatha was selected, Snehana was done with Murchita Sarshapa Taila, during Vishramakaala, Sarvanga Abhyanga was done with Murchita Sarshapa Taila and Baspa Sweda was done for 3 days. Virechana was given with Vishalapippali Yoga, followed by Rasarasayana Yoga, Neelakantha Rasa with Phalatrikadi Kwatha. Result showed that, there was very good improvement in the subjective parameters and objective parameter, FBS was reduced from 102.7 mg/dl to 98 mg/dl. PPBS were reduced from 145.6 mg/dl to 132 mg/dl. HbA1C was reduced from 8.4% to 5.8% after the intervention. In the contest of Madhumeha Chikitsa, Virechana is highlighted. In practice the newly diagnosed case of Madhumeha is reversible with timely Ayurvedic classical intervention. A significant improvement, in subjective and objective parameter of Madhumeha (DM2) has made it necessary to make a single case study.
Efficacy of Mind Sound Resonance Technique [MSRT] on Anxiety among Young Male Adults - A Randomized Controlled Trial
Authors: Joychand Singh  , Archana K  , Anupritha A Shetty  , Babbychand Bash  , Geetarani Devi
Published: March 2024

Background and Objectives: Anxiety disorder is a most common psychiatric disorder. Mind Sound Resonance Technique [MSRT] was developed using the concepts found in ancient writings that discuss the influence of Nadanusandhana [HathaYoga Pradipika] and Om [Mandukya Upanishad] in gaining internal control over mental changes. Mind Sound Resonance Technique was found to be beneficial in the management of anxiety. Therefore, the purpose of this study was to evaluate how mind sound resonance therapy affects anxiety disorder. Materials and Methods: 60 male participants between the ages of 18 to 30 were enrolled, and they were split into study and control groups at random. STAI Y1 & STAI Y2, DASS were assessed before and after 8 weeks of intervention. All the details of the study were explained and informed consent was obtained from the subjects. Result: Result suggested that experimental group demonstrated state anxiety [STAI-Y1] [p≤0.05], trait anxiety [STAI-Y2] [p≤0.05], depression [p≤0.05], anxiety [p≤0.05], and stress [p≤0.05] scores all significantly decreased. Interestingly in the control group a notable rise in trait anxiety was seen [STAI-Y2] [p ≤ 0.05] and a similar but less extent of reduction in scores on the DASS for depression [p≤0.05], anxiety [p≤0.05], and stress [p≤0.05]. Conclusion/Discussion: The current investigation found that using the Mind sound resonance approach for 8 weeks on Anxiety subjects has shown to be significantly reduce in State Anxiety scores [STAI-Y1], Trait anxiety [STAI-Y2], DASS- Depression Anxiety Stress scores.
Manajemen Budidaya Lebah Madu Klanceng (Trigona sp.) di Kelompok Tani Hutan (KTH) Telaga Lestari, Desa Ngebel, Kab. Ponorogo, Jawa Timur
Authors:   Fakultas Peternakan, Universitas Brawijaya, Awwally Khotibul Umam Al
Published: March 2024

Lebah klanceng (Trigona sp) merupakan lebah yang tidak bersengat dan berasal dari negara yang memiliki kawasan iklim tropis maupun subtropics. Budidaya lebah klanceng memiliki prospek tang tinggi dan dapat menjadi ekonomi alternative untuk masyarakat di Desa Ngebel. Tujuan kegiatan ini adalah untuk mengetahui manajemen pemeliharaan lebah madu Trigona sp mulai dari pengadaan koloni, produksi, pakan dan pengolahan madu. Dalam pembudayaan lebah madu Trigona sp beberapa yang perlu disiapkan adalah lokasi budidaya, setup untuk budidaya, koloni, pakaian kerja, dan peralatan lain yang diperlukan. Metode yang digunakan pada kegiatan ini adalah observasi, partisipasi, dan wawancara dengan peternak lebah madu klanceng di wilayah KTH Telaga Sari. Dari hasil kegiatan didapatkan bahwa manajemen budidaya lebah madu klanceng harus ditingkatkan untuk meningkatkan kualitas madu klanceng yang dihasilkan, yang dapat membawa Desa Ngebel sebagai salah satu sentra produksi madu klanceng di Indonesia.
Strategy for Handling Victims of Sexual Violence and Bullying by Unit Layanan Terpadu Kekerasan Seksual dan Perundungan (ULTKSP) Faculty of Vocational University of Brawijaya
Authors:   Fakultas Vokasi, Universitas Brawijaya, Malang, Indonesia, Susilowati Susilowati
Published: March 2024

The phenomenon of sexual violence and bullying that occurs on campus is often carried out by educated people, both fellow students, lecturers and education staff. With the increase in sexual violence that occurs in tertiary institutions, it will directly or indirectly have an impact on the less than optimal implementation of the Tridharma of Higher Education and reduce the quality of higher education. University of Brawijaya established Unit Layanan Terpadu Kekerasan Seksual dan Perundungan (ULTKSP), a unit that functions as an integrated service provider for victims of Sexual Violence and/or Bullying which is managed by University of Brawijaya and carried out by the Faculty, Postgraduate and Study Programs Outside the Main Campus. The strategy used to handle victims of sexual violence and/or bullying, namely services; Inspection; Protection; Recovery; Accompaniment; Prosecution of Perpetrators and Supervision.
Diversity of Fruit Flies (Diptera: Tephritidae) Attracted by Methyl Eugenol in Carambola and Papaya Orchads in Malang Regency, East Java, Indonesia
Authors: Setiawan Yogo , Hauroinsiyah Fatimah , Hamdoen Fadel Muhammad , Devi Mia Prastika , Tarno Hagus
Published: March 2024

Fruit flies (Diptera: Tephritidae) are among the significant pests in horticultural commodities. Methyl eugenol has been widely used for the detection, monitoring, and control of fruit fly worldwide. This study aimed to investigate the diversity of fruit flies attracted by methyl eugenol in carambola and papaya orchards in Malang Regency, East Java, Indonesia. Fruit flies were collected using modified plastic bottle traps, which were transformed into the Steiner trap model and attracted by methyl eugenol. The traps were placed in two study sites: papaya and carambola orchards. The results showed that three species of fruit flies were captured using methyl eugenol in this study: B. dorsalis, B. umbrosa, and B. carambolae. The most predominant species were B. dorsalis (86.02%), followed by B. carambolae (11.26%), and B. umbrosa (2.72%). Bactrocera dorsalis was the dominant species at both study sites.
A case of cerebellopontine angle meningioma presenting as neurovascular compression syndrome of the 8th cranial nerve
Authors: Jang Jeongin , Hong Sung Kwang , Song Joonho , Kim Hyung-Jong , Lee Hyo-Jeong
Published: March 2024

A 54-year-old female patient presented with paroxysmal tinnitus and vertigo for 2 years, which have repeatedly occurred while rotating her neck, and lasted about 10 seconds. An anticonvulsant medication was prescribed with a diagnosis of microvascular compression syndrome on the 8th cranial nerve and audiovestibular evaluation and magnetic resonance imaging (MRI) scan were appointed a week later. In her next visit, she reported the disappearance of paroxysmal audiovestibular symptoms after medication. In the left ear, canal paresis and abnormal auditory brainstem response were observed. In MRI, a large meningioma in the cerebellopontine angle in the vicinity of the internal auditory canal orifice was detected, that was surgically resected by a neurosurgeon. After surgical removal of the tumor, she reported continuous dizziness due to vestibular nerve injury, but the paroxysmal attack of tinnitus and vertigo disappeared without anticonvulsant medication. This case suggests that an imaging study is mandatory when diagnosing microvascular compression syndrome on the 8th cranial nerve.
Comparison of vestibular evoked myogenic potentials between low and high tone idiopathic sudden sensorineural hearing loss
Authors: Park Sang-Wook , Lee Sang Yun , Ryu Somi , Lee Jung Woo , Yim Chae Dong , Hur Dong Gu , Ahn Seong-Ki
Published: March 2024

Objectives: Vestibular evoked myogenic potentials (VEMP) have been reported to be useful in evaluating not only vestibular function but also the prognosis of idiopathic sudden sensorineural hearing loss (ISSNHL) patients. Even though low frequency, high frequency, and all frequency-involved ISSNHL groups tend to show varied clinical characteristics, there is a lack of data using VEMP results to analyze these subgroups. We investigated if the VEMP test is a valuable tool to predict recovery from hearing loss in association with different frequencies. Methods: A total of 26 ISSNHL patients were divided into three different groups impaired with low tone (ascending type), high tone (descending type), and all tones (flat type) based on the initial audiograms. Each group included five, 10, and 11 patents, respectively, and their VEMP results were compared between the three subgroups. Results: Abnormal VEMP results were found in five of the total 26 ISSNHL patients (19.2%). Two (40.0%), one (10.0%), and two (18.1%) patients of low tone, high tone, and all tone hearing loss groups, respectively, showed abnormal VEMP results. However, there was no statistically significant difference between the three groups. Conclusions: Even though VEMP is known as a valuable tool for predicting the prognosis of ISSNHL patients, it does not seem to reflect frequency-sensitive aspects of ISSNHL.