bluuebunny/crossref_metadata_2025 huggingface dataset:
Kondisi Ruh Ketika Mengalami Mimpi dalam Pandangan Islam dan Ilmuan Barat
Authors: Aulia Ulfa
Published: December 2021

Allah swt. telah menciptakan makhuk dengan akal dan jiwa dalam dirinya. Namun ilmu dan pengetahuan yang diberikan Allah swt. tidak selalu melalui hasil usaha makhluk-Nya. Salah satu yang sering dialami adalah ketika manusia tidur, yaitu bermimpi. Dalam Islam, mimpi dikategorikan menjadi dua hal, yaitu mimpi yang benar dan mimpi yang bathil. Dimana dalam beberapa mimpi, Allah swt. ingin menyampaikan pesan ataun petunjuk kepada yang mengalaminya. Namun dalam pandangan ilmuwan Barat, mereka tidak menyetujui pendapat tersebut. Mimpi yang benar dipahami mampu mengangkat ruh keluar dari jasad seseorang. Ruh itu berkelana, seperti halnya ketika manusia mengalami kematian.
Strategi Coping Stres Pada Mahasiswa Program Beasiswa Santri Berprestasi UIN Sunan Gunung Djati Bandung
Authors: Jayati Eva Agustina
Published: December 2021

Program Beasiswa Santri Berprestasi adalah salah satu program beasiswa penuh dari Kementrian Agama, di mana biaya yang ditanggung meliputi : living cost, biaya kuliah dan juga uang untuk pembinaan, seperti buku, dan lain sebagainya. Namun tidak menutup kemungkinan mahasiswa yang mendapatkan beasiswa ini tidak mengalami stres. Pada umumnya mahasiswa seringkali masih merasa terbebani walaupun sudah mendapatkan beasiswa yang akhirnya menimbulkan stres yang berkepanjangan. Bukan hanya pada aktivitas akademik, tetapi juga pada beberapa kewajiban yang menjadi persyaratan kelulusan penerima beasiswa ini, terutama mahasiswa program beasiswa santri berprestasi di UIN Sunan Gunung Djati Bandung. Penelitian ini bertujuan untuk mengetahui bagaimana strategi mahasiswa program beasiswa santri berprestasi melakukan strategi coping stres. Observasi ini menggunakan metode wawancara dan observasi. Peneliti mengambil jumlah subjek sebanyak 10 mahasiswa program beasiswa santri berprestasi di UIN Sunan Gunung Djati Bandung. Teknik analisis yang digunakan adalah metode deskriptif. Hasil penelitian ini menemukan bahwa mahasiswa program beasiswa santri berprestasi memiliki strategi coping yang positif dan berfokus pada penyelesaian pada emosi.
A rare cause of hypercalcemia : Two cases of parathyroid adenoma
Authors: HEPOKUR Merve Nur , ÖZKÖK Meltem , ÖNDER Asan , ÇAĞLAR Meltem , ÖZEMİR İbrahim Ali
Published: December 2021

Hypercalcemia is a rare but serious metabolic condition that may lead to end-organ damage. Primary hyperparathyroidism is a rare disease in children and adolescents and parathyroid adenoma is the most common cause. Most of patients are clinically symptomatic and may present signs or symptoms of hypercalcemia. The aim of this report is to describe two case of hypercalcemia due to parathyroid adenoma presenting with different clinical findings.
14 years old male patient with abdominal pain, vomiting and nausea were diagnosed with acute pancreatitis. His laboratory findings were elevated amylase and lipase levels, hyperglycemia, hypercalcemia and hyperparathyroidism. Parathyroid scintigraphy showed the presence of an adenoma. Normocalcemia was provided with pamidronate and hyperglycemia was treated with insulin. Adenoma excision was performed after acute pancreatitis was recovered with replacement therapy. After the surgery, diabetes mellitus persisted and he had a hungry bone syndrome.

Other patient was a 12-year-old male patient presented with complaints of anorexia, weakness, constipation and nausea. He had hypercalcemia, hypophosphatemia and hyperparathyroidism. Parathyroid adenoma was detected with parathyroid scintigraphy. Adenoma excision was performed and postoperatively he had a hungry bone syndrome.

Hypercalcemia associated with primary hyperparathyroidism is rare but generally symptomatic in children and adolescents. It should be kept in mind in the differential diagnosis of hypercalcemia and patients should be protected from complications and permanent damage.
THE BINARY GOLDBACH CONJECTURE
Authors: Feliksiak Jan
Published: December 2021

The Goldbach Conjecture, one of the oldest problems in mathematics, has fascinated and inspired many mathematicians for ages. In 1742 German mathematician Christian Goldbach, in a letter addressed to Leonhard Euler, proposed a conjecture. The modern-day version of the Binary/Strong Goldbach conjecture asserts that: Every even integer greater than 2 can be written as the sum of two primes. The conjecture had been verified empirically up to 4 × 1018, its proof however remains elusive, which seems to confirm that:

Some problems in mathematics remain buried deep in the catacombs of slow progress ... mind stretching mysteries await to be discovered beyond the boundaries of former thought. Avery Carr (2013)

The research was aimed at exposition, of the intricate structure of the fabric of the Goldbach Conjecture problem. The research methodology explores several topics, before the definite proof of the Goldbach Conjecture can be presented. The Ternary Goldbach Conjecture Corollary follows the proof of the Binary Goldbach Conjecture as well as the representation of even numbers by the difference of two primes Corollary. The research demonstrates that the Goldbach Conjecture is a genuine arithmetical question.
EDUCAÇÃO AMBIENTAL, ARTE E FOTOGRAFIA – Uma perspectiva estética de natureza no Pampa
Authors: Schlee Renata lobato , Henning Paula Corrêa , Ratto Cleber Gibbon
Published: December 2021

Este artigo busca analisar como se fabrica um discurso de natureza no Pampa do Rio Grande do Sul, Brasil; e Uruguai; região sul da América do Sul. Discute-se a relação entre natureza e cultura problematizando os enunciados e visibilidades de entrevistas e imagens produzidas por “fotógrafos de natureza” do Brasil e do Uruguai. A partir do campo teórico escolhido, declara-se o que se entende por arte e de como a fotografia participa de construções discursivas. No foco de uma educação ambiental pelo viés das experiências estéticas, tensiona-se o corpus discursivo, estimulando um agir sobre nossas relações natureza-cultura. O propósito do texto é provocar e desafiar o impensado e, quem sabe, transvalorar o que está dado como verdade instituída nesse campo. Para tanto, percorremos os caminhos teóricos de Michel Foucault, Gilles Deleuze, Felix Guattari e Friedrich Nietzsche.
Synthesis and Crystal Structure of New Zn(II) Complex with N-[bis(benzylamino)phosphoryl]-2,2,2-trichloroacetamide
Authors: Zozulia Valeriia , Ovchynnikov Vladimir , Slyva Tetiana , Rusanova Julia , Amirkhanov Volodymyr
Published: December 2021

The novel binuclear Zn(II) complex of general formula Zn2(L)4(CH3OH)2 where HL is N-[bis(benzylamino)phosphoryl]-2,2,2-trichloroacetamide has been synthesized from non-aqueous solution and characterized by elemental analysis, FTIR and NMR spectroscopy as well by X-ray single crystal diffraction. This complex represents the third example of binuclear complexes with this ligand within four known for today.
Determinations of volatile compounds in Bozcaada Cavusu grape variety cultivated at different locations of Bozcaada
Authors: GÜNDOĞDU Mehmet Ali , ŞEKER Murat , DARDENİZ Alper , ŞAHİN Esra , EREN Ramazan
Published: December 2021

Objective: The objective of this study was determine the ratios of volatile components in the ‘Bozcaada Cavusu’ grape variety cultivated in ‘Cayir’, ‘Sulubahce’ ve ‘Ova’ locations of ‘Bozcaada and conducted in 2013.

Material and Methods: The thirty years old goble vineyards grafted on "5BB" rootstock at different locations of Bozcaada and applied equal care conditions were selected as research material. ‘Bozcaada Cavusu’ grape variety was harvested at different locations at the harvest date and cluster samples were taken in the same day.

Results: Based on the findings from the study, it could be stated that some terpenes detected in grape varieties with ‘Muscat’ aroma were also major volatile components in the ‘Bozcaada Cavusu’ grape variety and this variety provided had a very pleasant aroma. Except terpenes, the ‘Bozcaada Cavusu’ grape variety was also rich in compounds with 6 carbons (C6 compounds) which formed by lipoxygenase pathway, usually the desired aroma compounds in grapes and fruits.

Conclusion: Among these compounds, it was determined that especially E–2–hekzenal and hexanal compounds were the major compounds in the aldehydes group whereas hexanol and Z–3–hekzenol compounds were the major compounds in the alcohols group and they were effective in the formation of the desired flavor specific to the variety.
The effects of different harvest maturity and methods on fruit and oil quality of olive (Olea europea L. cv. Ayvalık Yağlık)
Authors: ŞEN Fatih , ESEN Ayça
Published: December 2021

Objective: This study was conducted to determine the effects of harvest time and method on fruit and oil characteristics of ‘Ayvalık Yağlık’, a major olive cultivar in Turkey.

Material and Methods: Early, optimum and late harvests were made by hitting with a wood stick (control), pneumatic beater, and branch shaker in a conventional olive grove located in Edremit district of Balıkesir province in western Turkey. Harvested olive fruits were stored at 18-20°C for 3 days, and physical, biochemical attributes, free acidity, and fatty acid composition, and mechanical damage caused by tested harvest methods were evaluated.

Results: Mechanical damage index and free fatty acidity were lower in olive fruits harvested by branch shakers compared to those dropped down by stick. Fruit weight, maturity index, oil content and linoleic acid content increased with the progress of harvest date, while color, moisture content, free fatty acids, total phenolics, and palmitic, stearic, and linolenic acid ratio decreased at the last harvest date.

Conclusion: The results showed that significant changes in some physical and chemical properties of the olive fruit occur with the progression of maturity, and using branch shakers and harvesting on the 2nd and 3rd harvest dates are recommended for Ayvalık variety under the experimental site conditions.
Louis Carton (1861-1924) et les religions d’Afrique
Authors: Podvin Jean-Louis
Published: December 2021

Médecin militaire, Louis Carton découvre la Tunisie en 1886 et s’adonne avec passion à l’archéologie. Il y découvre de nombreux sites, et devient une référence dans ce domaine, même s’il entre rapidement en lutte avec les autorités archéologiques officielles. Plus spécialisé dans les domaines de la colonisation romaine et des travaux d’irrigation, il aborde cependant à de multiples reprises le champ religieux.
Haltour: millennial generation halal tourism literature media
Authors: Sunardi M. Heru , Nuraeni Siti , Nurdin Musdin La
Published: December 2021

Development in the management of Indonesian Halal Tourism is felt to be increasingly important along with the entry of the Millennial Era. Based on research on the performance of several Halal Tourism Managers, the current optimization of the Halal Tourism sector is still far from the potential of Halal Tourism as it should be, so Halal Tourism Managers need to take progressive steps by implementing a digitalization system. This article aims to reveal the challenges faced by Halal Tourism in terms of Literacy and Socialization of Halal Tourism in the Millennial Era, complete with the obstacles faced. In addition, it was stated about the form of strategies for using digital literacy channels, one of which: social media to carry out more optimal Halal Tourism literacy. This research is a qualitative research, using a literature study approach. The data collected related to the research were taken from several literature sources including scientific journals, several books, and related articles published in online media. As a result, by transforming towards using digital literacy channels, the management and development program for Halal Tourism can be carried out better and at the same time be able to educate the public about Halal Tourism in Indonesia.
THROUGHPUT INCREASE IN THE OFFICE LI-FI SYSTEM
Authors: Romanov Oleksandr , Miklaiv Gleb
Published: December 2021

Background. Wi-Fi has many disadvantages, such as how the maximum bandwidth is limited by the frequency of the range. The work uses Li-Fi technology, which uses visible light for data transmission. The frequency range of Li-Fi is 1000 times greater than the entire radio range. Feedback is used to increase the throughput. But the feedback decreases the bandwidth of the downstream signal.

Objective. The purpose of the paper is to analyse what parameters are advisable to change to increase the throughput of the Li-Fi system.

Methods. Study of the simulated dependence of the optimal interval change for using the feedback, and using this interval plot the dependence of the throughput on the change in the parameters of the Li-Fi system with a mobile user.

Results. With an increase in the area of the photodiode and its refractive index, the throughput increases. As the receiver speed increases, the throughput decreases slightly <0.1%. Reducing the angle of the photodiode field of view and the half-angle of radiation significantly increases the throughput (by 50%) only when decreasing to small angles (<10 °).

Conclusions. It is advisable to make photodiode from a material with a high refractive index, with a big area. Since mobile devices are often used in the office Li-Fi network, it is not advisable to reduce the receiver's viewing angle, as well as to reduce the half-angle of radiation. It may also be beneficial to give mobile users more download throughput than upload throughput.
Algebraic Characteristics of the Matrix Conversions Class and Its Hardware Implementation
Authors: Kudlai Stanislav V.
Published: December 2021

This paper derives the algebraic characteristic of the matrix transformations class by the method of isomorphic mappings on the algebraic characteristic of the class of vector transformations using the primitive program algebras. The paper also describes the hardware implementation of the matrix operations accelerator based on the obtained results. The urgency of the work is caused by the fact that today there is a rapid integration of computer technology in all spheres of society and, as a consequence, the amount of data that needs to be processed per unit time is constantly increasing. Many problems involving large amounts of complex computation are solved by methods based on matrix operations. Therefore, the study of matrix calculations and their acceleration is a very important task. In this paper, as a contribution in this direction, we propose a study of the matrix transformations class using signature operations of primitive program algebra such as multi place superposition, branching, cycling, which are refinements of the most common control structures in most high-level programming languages, and also isomorphic mapping. Signature operations of primitive program algebra in combination with basic partial-recursive matrix functions and predicates allow to realize the set of all partial-recursive matrix functions and predicates. Obtained the result on the basis of matrix primitive program algebra. Isomorphism provides the reproduction of partially recursive functions and predicates for matrix transformations as a map of partially recursive vector functions and predicates. The completeness of the algebraic system of matrix transformations is ensured due to the available results on the derivation of the algebraic system completeness for vector transformations. A name model of matrix data has been created and optimized for the development of hardware implementation. The hardware implementation provides support for signature operations of primitive software algebra and for isomorphic mapping. Hardware support for the functions of sum, multiplication and transposition of matrices, as well as the predicate of equality of two matrices is implemented. Support for signature operations of primitive software algebra is provided by the design of the control part of the matrix computer based on the RISC architecture. The hardware support of isomorphism is based on counters, they allow to intuitively implement cycling in the functions of isomorphic mappings. Fast execution of vector operations is provided by the principle of computer calculations SIMD.
БІОЛОГІЧНІ ПАТОГЕННІ АГЕНТИ ГЕННО-ІНЖЕНЕРНОГО ПОХОДЖЕННЯ ТА БІНАРНА БІОЛОГІЧНА ЗБРОЯ
Authors: Худецький І. , Антонова-Рафі Ю. , Даниленко Ю. , Худецька Н.
Published: December 2021

Історія людства як біологічного виду та історія людини розумної в значній мірі пов’язана з патогенними біологічними агентами, які з доісторичних часів були причиною пандемій чи використовувались як зброя. Розвиток і удосконалення будь якої зброї тісно пов’язаний з розробкою нових технологій. Лікування пацієнтів з інфекційними захворюваннями, захист людей під час пандемій також тісно пов’язані з новими технологіями. Двадцять перше століття характерне бурхливим розвитком біотехнологій та генної інженерії, які можуть мати вирішальне значення у лікуванні багатьох хвороб та надати небезпечний поштовх розвитку нових видів біологічної зброї. Пандемія COVID-19 продемонструвала величезний вплив, який може мати на суспільство один біологічний патогенний агент, щодо природного походження якого експерти не дали остаточної однозначної відповіді. Небезпека  розробки нових видів біологічної зброї та застосування її для війни, диверсій, терору, шантажу, отримання надприбутків чи в кримінальних злочинах зростає з розвитком біотехнологій. Знання про можливі шляхи розвитку біологічної зброї дозволяє вибудовувати систему біобезпеки та біозахисту в кожній країні зокрема та на планеті в цілому. Постіндустріальна епоха створює загрозу нових вірусів або хвороб, поява яких може бути спровокована сільськогосподарським чи промисловим освоєнням нових територій. А глобальні системи комунікації сприяють майже миттєвому поширенню небезпечних інфекцій. Останні досягнення в галузі біохімії, генетики та молекулярної біології зробили можливим створення живих організмів. Хоча ці розробки пропонують ефективні засоби для лікування хвороб, збільшення виробництва їжі та покращення якості життя багатьох людей, вони також можуть використовуватися державними та недержавними структурами для розробки нових видів біологічної зброї. Доступність фундаментальної біологічної науки, інформації про генну інженерію та біотехнології, модульний принцип досліджень, бази готових рішень, доступність матеріалів знижують рівень навичок, необхідний для проведення неконтрольованих досліджень біологічних патогенних агентів чи розробки біологічної зброї. В роботі проаналізовані загрози, пов’язані з можливістю застосування генної інженерії та сучасних біоінженерних технологій для розробки генетично модифікованих біологічних патогенних агентів, бінарної та інших нових видів біологічної зброї.

Ключові слова: біологічні патогенні агенти, емерджентні та ре-емерджентні інфекції, біологічна зброя, бінарна біологічна зброя, біобезпека, біозахист
Inequities in Chlamydia trachomatis Screening Between Black and White Adolescents in a Large Pediatric Primary Care Network, 2015–2019
Authors: Wood Sarah , Min Jungwon , Tam Vicky , Pickel Julia , Petsis Danielle , Campbell Kenisha
Published: December 2021

Objectives. To identify associations between patient race and annual chlamydia screening among adolescent females.

Methods. We performed a retrospective cohort study of females aged 15 to 19 years in a 31-clinic pediatric primary care network in Pennsylvania and New Jersey from 2015 through 2019. Using mixed-effect logistic regressions, we estimated associations between annual chlamydia screening and patient (race/ethnicity, age, previous chlamydia screening and infection, insurance type) and clinic (size, setting) characteristics. We decomposed potential effects of clinician’s implicit racial bias and screening, using covariates measuring the proportion of Black patients in each clinician’s practice.

Results. There were 68 935 well visits among 37 817 females, who were 28.8% Black and 25.8% Medicaid insured. The mean annual chlamydia screening rate was 11.1%. Black females had higher odds of screening (adjusted odds ratio [AOR] = 1.67; 95% confidence interval [CI] = 1.51, 1.84) than did White females. In the clinician characteristics model, individual clinicians were more likely to screen their Black versus non-Black patients (AOR = 1.88; 95% CI = 1.65, 2.15).

Conclusions. Racial bias may affect screening practices and should be addressed in future interventions, given the critical need to increase population-level chlamydia screening.(Am J Public Health. 2022;112(1):135–143. https://doi.org/10.2105/AJPH.2021.306498 )
Defining Child Exposure to Domestic Violence: Lessons from a Historical Review of the Literature
Authors: Howard Stephanie
Published: December 2021

Child witnesses of domestic violence policies and practices have been fraught with conceptual challenges that limit their implementation. Such limitations are evident in the case of Minnesota, which amended their definition of child neglect to include a child’s exposure to family violence, only to later repeal this amendment in response to pressure from child welfare administrators and domestic violence advocates (Edleson, Gassman-Pines, & Hill, 2006; Kantor & Little, 2003). The conceptual flaws are also evident in disparities across state statutes for definitions of child witnesses of domestic violence and the legal penalties it carries (Child Welfare Information Gateway, 2021). To enhance the integrity of child witnesses of domestic violence policies and practices, critical attention is needed to clarify and refine the central construct. Pursuant to this goal, this conceptual paper analyzes and synthesizes the history of child welfare. It demonstrates how child witnesses of domestic violence became a social and legal problem. The author traces the evolution of child welfare as a concept and provides new insights. The author also sheds light on the driving forces of child welfare policies and practices. The paper begins in the colonial ages, which gave roots to the contemporary child welfare system. The author describes the early development of child welfare leading to contemporary practice. The paper ends by making evidence-based recommendations for constructing child welfare policies that enhance the safety of children exposed to domestic violence using least restrictive interventions.
Child Protection Vocabulary in the Children Act 1989: Power, Ambiguity and Heterogeneity
Authors: Pentaris Panagiotis , Oresanya Abiola
Published: December 2021

Regardless the few decades that an established legislative framework in Child Protection has been in effect, the responsibility of the Law and the Child Protection System is to continuously explore social needs, as they change, transform or new ones are introduced to adapt to the circumstances in the attempts to safeguard and protect children. This paper is not focusing on those adaptations; it draws on this responsibility to argue that in an ever-changing world, wherein needs and demands are shifting, Child Protection Vocabulary needs to be more explicit and adaptive to those changes. Vocabulary like ‘best interest’, ‘resilience’, ‘power’, and ‘vulnerability’ are commonplace in child protection legislation, regulation, policy and practice. That said, the question of interpretation is always of concern; how are the varied agencies, stakeholders, authorities, groups, and individuals approaching safeguarding and child protection when the heterogeneity of the language used is ever-increasing? This paper provides a conceptual content analysis of Child Protection Vocabulary found in the Children Act 1989. The analysis will be drawing on the amendments in Children Act 2004, as well as the Children and Social Work Act 2017, but will preserve its focus on the Children Act 1989 as the foundation for the contemporary Child Protection System. Implications of the findings are provided at the end.
Dynamin 3 Gene as a Tumor Suppressor and an Independent Predictive Factor of Poor Prognosis in Patients with Gastric Cancer
Authors: Tu Ru-Hong , Lin Jian-Xian , Xie Jian-Wei , Wang Jia-Bin , Lu Jun , Chen Qi-Yue , Cao Long-Long , Lin Mi , Huang Ze-Ning , Lin Ju-Li , Zheng Hua-Long , Li Ping , Zheng Chao-Hui , Huang Chang-Ming
Published: December 2021

Gastric cancer is a leading cause of death from malignant tumors worldwide. With the development of genome sequencing technology, an increasing number of key driver genes and tumor suppressors have been discovered. Some studies have suggested that Dynamin 3 (DNM3) is a novel tumor suppressor; however, the role of DNM3 in malignancy remains unclear. We performed a systematic analysis using The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD) cohorts, and 160 patients with stomach adenocarcinoma at Fujian Medical University Union Hospital (FJMUUH) (48 quantitative PCR [qPCR] and 112 immunohistochemistry). DNM3 expression was found to be downregulated in gastric cancer compared to that in paraneoplastic tissue. Low expression of DNM3 was mainly associated with DNM3 promoter hypermethylation status. Low expression of DNM3 can upregulate the tumor cell cycle and oxidative phosphorylation process and downregulate immune regulation, and Th17 and Th2 immune cell infiltration was increased in patients with lower expression of DNM3. Patients with a lower DNM3 expression had a higher rate of lymph node metastasis and poor prognosis. In summary, DNM3 is a tumor suppressor and an independent predictive factor of poor prognosis that regulates the cell cycle and immunosuppression in the tumor microenvironment in gastric cancer via methylation.
Robust Self-Triggered Control for Nonlinear Cyber-Physical Systems with State Constraints under DoS Attacks
Authors: Cuan Zhaoyang , Ding Dawei , Wang Heng
Published: December 2021

This paper is concerned with the event-based control problem for nonlinear cyber-physical systems (CPSs) with state constraints. A novel security control strategy consisting of a self-triggered mechanism is developed to decrease the network communication loads to the most extent on the basis of ensuring system safety and stability. The maximum capability of the designed self-triggered mechanism to resist denial-of-service (DoS) attacks occurring in controller-actuator (C-A) and sensor-controller (S-C) channels synchronously is also analyzed. In particular, we prove that the security control strategy guarantees the system safety and stability without resulting in Zeno behavior. Finally, a numerical example is provided to demonstrate the prominent effectiveness and the advantages over the existing results.
Penalized Logistic Regressions with Technical Indicators Predict Up and Down Trends
Authors: Jiang Huifeng , Hu Xuemei , Jia Hong
Published: December 2021

Predicting up and down trends for stock prices is an important puzzle in the financial field. Hu & Jiang (2021) proposed logistic regression with 6 technical indicators to predict up and down trends for Google's stock prices. In this paper we further propose the five penalized logistic regressions with 19 technical indicators: ridge (L2), lasso (L1), elastic net(EN), smoothly clipped absolute deviation (SCAD) and minimax concave penalty (MCP) to improve the prediction accuracy. Firstly, we combine the iterative weighted least square algorithm with the coordinate descent algorithm, and apply a training set to obtain parameter estimators and probability estimators. Then we adopt a test set to construct confusion matrices and receiver operating characteristic (ROC) curves, and apply them to assess their prediction performances. Finally we compare the proposed five prediction methods with logistic regression, support vector machine (SVM) and artificial neural network (ANN) , and found that the MCP penalized logistic regression performs the best. Therefore, we develop a new efficient prediction method to predict up and down trends for stock prices.
Diagnostic Accuracy of Dual-energy CT for Bone Marrow Edema in Patients with Acute Knee Injuries: A Systematic Review and Meta-analysis
Authors: Chen Xuelong , Li Zhizhuo , Fang Hui , Yin Xiangyang , Li Chengxin , Shi Lijun , Fan Xiaoyu , Xu Xin , Gao Fuqiang , SUN WEI
Published: December 2021

Background: The prevalence of knee injury is high and early diagnosis is significant to guide clinical treatment. MRI is recognized as the gold standard for detecting bone marrow edema (BME) in patients with acute knee injury, but limitations still exist. Dual-energy CT (DECT) is investigated as a promising alternative.Methods: We systematically retrieved studies from EMBASE, Scopus, PUBMED, and the Cochrane Library and collected gray literatures. According to PRISMA-DTA guidelines, a systematic review was performed from inception to July 31, 2021, assessing the diagnostic accuracy of DECT for detecting BME in at least 10 adult patients with acute knee injuries and with an MRI reference standard. Study details were independently extracted by two reviewers. Meta-analysis was performed using a bivariate mixed-effects regression model with subgroup analysis performed to evaluate for sources of variability. Results: Nine studies evaluating 290 patients between the ages of 23–53 with acute knee injuries undergoing DECT and MRI were included in analysis. Summary sensitivity, specificity, and AUC values for BME were 85% (95% confidence interval (CI) 77–90%), 96% (95% CI 93–97%), and 0.97 (95% CI 0.95–0.98), respectively. There were no statistically significant differences in specificity and sensitivity amongst comparative subgroups to account for presumed variability amongst studies.Conclusion: DECT is accurate for detecting BME in patients with acute knee injuries and can be used as an alternative to MRI, particularly when MRI is contraindicated or unavailable.
Bimetallic Fe/Al-MOF for the Adsorptive Removal of Multiple Dyes: Optimization and Modeling of Batch and Hybrid Adsorbent-river Sand Column Study
Authors: Singh Hemant , Raj Sankalp , rathour Rishi karan singh , Bhattacharya Jayanta
Published: December 2021

Bimetallic Metal organic framework (MOF) has garnered interest over the years with its application in various environmental remediation. In this study, Fe-Al-1,4-Benzene di-Carboxylic acid (FeAl(BDC)) MOF was synthesized, and adsorptive removal of Rhodamine B dye in batch and unique hybrid FeAl (BDC)-River sand fixed-bed column was achieved. The experimental data from the batch studies corroborated well with the Pseudo second-order (PSO) and Freundlich adsorption isotherm models. Furthermore, a fixed-bed column study was conducted to assess the effect of varying flow rate (2, 5, 8 mL/min), bed height (5, 9, 13 cm), and feed concentration (10, 20, 30 mg/L) on the adsorption performance of FeAl(BDC) in continuous mode of operation. A uniform mixture of river sand and FeAl(BDC) by weight ratio (9:1) was achieved prior to packing the column. The column study reveals that Sand-FeAl(BDC) can achieve the maximum adsorption capacity of 113.05 mg/g at a flow rate of 5 mL/min, feed concentration of 20 mg/L, and bed height of 13 cm. The experimental data of the column study were successfully fitted with BDST, Thomas, Yoon-Nelson, and Dose-response models. The fitting parameter values from the BDST model raise the scope of possible upscaling of the fixed-bed column. Hence, it is proposed that these River sand-FeAl(BDC)-based filters can be widely used in areas facing critical contamination and in poor communities with a high demand for water.
Nanomaterials for Sustainability: A Review on Green Synthesis of Nanoparticles Using Microorganisms
Authors: Jadoun Sapana , Chauhan Narendra Pal Singh , Zarrintaj Payam , Barani Mahmood , Varma Rajender S.
Published: December 2021

Nanotechnology has permeated all areas of sciences as one of the most propitious technology with the deployment of nanoparticles in environmental remediation and biomedical fields; their synthesis under greener conditions has been bourgeoned using microorganisms, plants, etc. to decrease the use of toxic chemicals. Synthesis of nanoparticles by exploiting microorganisms has opened up a new prospect at the interface of nanotechnology, chemistry, and biology enabling access via a biocompatible, safe, sustainable, eco-friendly, and reliable route; microorganisms offer crystal growth, stabilization, and prevention of aggregation thus performing a dual role of reducing and capping agent because of the presence of biomolecules such as enzymes, peptides, poly (amino acids), polyhydroxyalkanoate (PHA), and polysaccharides. Herein, the microorganisms-based synthesis of various nanoparticles comprising gold, silver, platinum, palladium, copper, titanium dioxide, zinc oxide, iron oxide, and selenium along with their appliances in waste treatment, biomedicine namely cancer treatment, antibacterial, antimicrobial, antifungal, and antioxidants, are deliberated.
Gingival Epithelial Cell-Derived Microvesicles Activate Mineralization in Gingival Fibroblasts
Authors: Kobayashi Shuichiro , Bi Jiarui , Owen Gethin , Larjava Nelli , Koivisto Leeni , Häkkinen Lari , Larjava Hannu
Published: December 2021

Soft tissue calcification occurs in many parts of the body, including the gingival tissue. Epithelial cell-derived MVs can control many functions in fibroblasts but their role in regulating mineralization has not been explored. We hypothesized that microvesicles (MVs) derived from gingival epithelial cells could regulate calcification of gingival fibroblast cultures in osteogenic environment. Human gingival fibroblasts (HGFs) were cultured in osteogenic differentiation medium with or without human gingival epithelial cell-derived MV stimulation. Mineralization of the cultures, localization of the MVs and mineral deposits in the HGF cultures were assessed. Gene expression changes associated with MV exposure were analyzed using gene expression profiling and real-time qPCR. Within a week of exposure, epithelial MVs stimulated robust mineralization of HGF cultures that was further enhanced by four weeks. The MVs taken up by the HGF's did not calcify themselves but induced intracellular accumulation of minerals. HGF gene expression profiling after short exposure to MVs demonstrated relative dominance of inflammation-related genes that showed increases in gene expression. In later cultures, OSX, BSP and MMPs were significantly upregulated by the MVs. These results suggest for the first time that epithelial cells maybe associated with the ectopic mineralization process often observed in the soft tissues.
In Vitro Assessment of 17 Antimicrobial Agents Against Clinical Mycobacterium Avium Complex Isolates
Authors: Lin Siran , Hua Wenya , Wang Shiyong , Zhang Yu , Chen Xinchang , Liu Hong , Shao Lingyun , Chen Jiazhen , Zhang Wenhong
Published: December 2021

Background: Recently, Mycobacterium avium complex (MAC) infections have been increasing, especially in immunocompromised and older adults. The rapid increase has triggered a global health concern due to limited therapeutic strategies and adverse effects caused by long-term medication. To provide more evidence for the treatment of MAC, we studied the in vitro inhibitory activities of 17 antimicrobial agents against clinical MAC isolates.Results: A total of 111 clinical MAC isolates were enrolled in the study and they were identified as M. intracellulare, M. avium, M. marseillense, M. colombiense, M. yongonense, M. arosience, and one isolate was undifferentiated at subspecies level. MAC strains had relatively low (0–21.6%) resistance to clarithromycin, amikacin, bedaquiline, rifabutin, streptomycin, and clofazimine, and the resistant rates to isoniazid, rifampin, linezolid, doxycycline, and ethionamide were very high (72.1–100%). In addition, M. avium and M. intracellulare had different resistance profiles for clarithromycin, ethambutol, trimethoprim/sulfamethoxazole, amikacin, linezolid, clofazimine, cycloserine, and ethionamide. Conclusions: Our results supported the current usage of macrolides, rifabutin, and aminoglycosides in the regimens for MAC infection, and also demonstrated the low resistance rate against new drugs, such as clofazimine, tedizolid, and bedaquiline, suggesting the possible implementation of these drugs in MAC treatment.
PA1 Participates in the Maintenance of Blood-Testis Barrier Integrity via Cooperation with JUN in the Sertoli Cells of Mice.
Authors: Liu Bo , Liu Chao , Ma Binfang , Zhang Ruidan , Zhao Zhiwei , Xiao Sai , Cao Wanjun , Ma Yanjie , Zhu Guozhang , Li Wei , Li Zhen
Published: December 2021

BackgroundThe blood-testis barrier (BTB) is essential to the microenvironment of spermatogenesis, and Sertoli cells provide the cellular basis for BTB construction. Numerous nuclear transcription factors have been identified to be vital for the proper functioning of Sertoli cells. PA1 has been reported to play important roles during diverse biological processes, yet its potential function in male reproduction is still unknown. ResultsHere, we show that PA1 was highly expressed in human and mouse testis and predominantly localized in the nuclei of Sertoli cells. Sertoli cell-specific Pa1 knockout resulted in an azoospermia-like phenotype in mice. The knockout of this gene led to multiple defects in spermatogenesis, such as the disorganization of the cytoskeleton during basal and apical ectoplasmic specialization and the disruption of the BTB. Further transcriptomic analysis, together with Cut-Tag results of PA1 in Sertoli cells, revealed that PA1 could affect the expression of a subset of genes that are essential for the normal function of Sertoli cells, including those genes associated with actin organization and cellular junctions such as Connexin43 (Cx43). We further demonstrated that the expression of Cx43 depended on the interaction between JUN, one of the AP-1 complex transcription factors, and PA1. ConclusionOverall, our findings reveal that PA1 is essential for the maintenance of BTB integrity in Sertoli cells and regulates BTB construction-related gene expression via transcription factors. Thus, this newly discovered mechanism in Sertoli cells provides a potential diagnostic or even therapeutic target for some individuals with azoospermia.
Identification of Hub Genes And Potential Molecular Mechanisms In Peripheral Blood Mononuclear Cells of Patients With Parkinson’s Disease
Authors: Li Zhi-Hui , Wang Guang-Tian , Chi Chun-Ling , Zhou Yu-Nan , Liu Dan , Wang Feng-Shuang , Liu Bin
Published: December 2021

Parkinson's disease (PD) is the second most common neurodegenerative disease. The pathogenesis of PD remains elusive, however PD appears to be caused by a complex interaction between environmental and genetic factors affecting various biological processes. The purpose of the present study is to identify hub genes and potential molecular mechanisms in peripheral blood mononuclear cells (PBMCs) of PD patients to aid early diagnosis and start treatment promptly. Two gene expression profiles (GSE22491 and GSE100054) were obtained from the Gene Expression Omnibus (GEO) database, in which 20 PBMC samples from PD patients and 17 controls were included, and the genes were analyzed with GEO2R. 1382 and 512 differentially expressed genes (DEGs) were identified in GSE22491 and GSE100054, respectively. Additionally, a total of 80 significant DEGs were found to co-exist in the two microarray datasets via Venn diagram. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed, which showed that the DEGs were mainly enriched in platelet degranulation, blood coagulation, nitric oxide mediated signal transduction, positive regulation of GTPase activity and cellular response to lipopolysaccharide. PPI network, microRNA (miRNA) - hub gene network, and transcription factor (TF)- hub gene network were constructed. In summary, the present study provides data of potential diagnostic biomarkers and therapeutic targets for PD. SRC may be a potential target for the treatment of PD. Additionally, three TFs (HNF4A, CDX2 and FUS), three miRNAs (hsa-miR-16-5p, hsa-miR-103a-3p and hsa-miR-107), may be involved in PD.
Adsorption Free Energy of Glycine on TiO2 in Water from First Principles Simulations and Electrochemical Impedance Spectroscopy
Authors: Agosta Lorenzo , Fiore Luca , Colozza Noemi , Lyubartsev Alexander , Arduini Fabiana , Hermansson Kersti
Published: December 2021

The adhesion of amino acids and small organic molecules on TiO2 nanoparticles is fundamental for bio-nano functionalization of peptides and proteins. The adsorption free energy is the main physical quantity that regulates the adsorption process. Its evaluation is particularly challenging both experimentally, due to the weak interfacial signal in aqueous environments, and by atomistic simulations, due to the complexity of the physical phenomena occurring at the solid-water interface (polarization and charge transfer effects). We report here an accurate experimental-computational study of hydrated TiO2 nanoparticles interacting with Glycine where we obtain quantitative agreement of the measured adsorption free energy. Ab-initio simulations are performed within the Tight Binding Density Functional Theory in combination with enhanced free energy sampling techniques. The experiments adopt a new and efficient set-up for electrochemical impedance spectroscopy measurements based on screen-printed gold electrodes. The measured adsorption free energy is about -30 kJ/mol (both from experiment and calculation), with preferential interaction of the charged NH3 group which strongly adsorbs on the TiO2 bridging oxygens. The perfect agreement between computation and experiment opens the doors to an extended exploration of the bio-nano interaction for different materials and molecules.
Prognostic Impact of Pelvic Lymph Node Dissection During Radical Prostatectomy on Patients With High-risk Prostate Cancer Treated With Neoadjuvant Chemohormonal Therapy
Authors: Iwamura Hiromichi , Hatakeyama Shingo , Narita Takuma , Ozaki Yusuke , Konishi Sakae , Horiguchi Hirotaka , Kodama Hirotake , Kojima Yuta , Fujita Naoki , Okamoto Teppei , Tobisawa Yuki , Yoneyama Tohru , Yamamoto Hayato , Yoneyama Takahiro , Hashimoto Yasuhiro , Ohyama Chikara
Published: December 2021

BackgroundWe aimed to determine the prognostic and staging benefit of limited pelvic lymph node dissection (PLND) during radical prostatectomy (RP) in high-risk prostate cancer (PC) patients treated with neoadjuvant chemohormonal therapy.MethodsWe retrospectively analyzed 516 patients with high-risk localized PC (<cT4N0M0) who received neoadjuvant androgen-deprivation therapy plus estramustine phosphate followed by RP between January 2010 and March 2020. Since we stopped limited-PLND for such patients in October 2015, we compared the biochemical recurrence-free survival (BCR-FS) between the limited-PLND group (before October 2015, n = 283) and the non-PLND group (after November 2015, n = 233).ResultsThe rate of node metastases in the limited-PLND group were 0.8% (2/283). Operation time was significantly longer (176 vs. 162 min) and the rate of surgical complications were much higher (all grades; 19 vs. 6%, grade ≥ 3; 3 vs. 0%) in the limited-PLND group. The inverse probability of treatment weighting-Cox analysis revealed limited PLND had no significant impact on BCR-FS (hazard ratio, 1.31; P = 0.421).ConclusionsLimited PLND during RP after neoadjuvant chemohormonal therapy showed a relatively low rate of positive nodes, higher rate of complications, and no significant impact on BCR-FS.
Risk of Adverse Fetal Outcomes Following Nonobstetric Surgery During Gestation: A Nationwide Population-Based Analysis
Authors: Fu Pei-Han , Yu Chia-Hung , Chen Yi-Chen , Chu Chin-Chen , Chen Jen-Yin , Liang Fu-Wen
Published: December 2021

Background: Literature suggests that nonobstetric surgery during gestation is associated with a higher risk of spontaneous abortion, prematurity, and a higher cesarean section rate, but the direct impact on fetal outcomes is still unclear. In this study, we aimed to investigate whether nonobstetric surgery during pregnancy is associated with negative fetal outcomes by analysing a nation-wide database in Taiwan.Methods: This population-based retrospective observational study was based on the linkage of Taiwan’s National Health Insurance Research Database, Birth Reporting Database, and Maternal and Child Health Database between 2004 and 2014. For every pregnancy with nonobstetric surgery during gestation, four controls were randomly matched according to maternal age and delivery year. We estimated adjusted odds ratios (aOR) and 95% confidence intervals (CIs) of adverse fetal outcomes with the non-surgery group as the reference. The primary outcomes involved stillbirth, prematurity, low birth weight, low Apgar scores, and neonatal and infant death.Results: Among 23,721 identified pregnancies, 4,747 underwent nonobstetric surgery. Pregnancies with nonobstetric surgery had significantly higher risks of prematurity (aOR: 1.46; 95% CI: 1.31–1.62), lower birth weight (aOR: 1.49; 95% CI: 1.33–1.67), Apgar scores <7 (1 min, aOR: 1.58; 95% CI: 1.33–1.86; 5 min, aOR: 1.34; 95% CI: 1.03–1.74), neonatal death (aOR: 2.01; 95% CI: 1.18–3.42), and infant death (aOR: 1.69; 95% CI: 1.12–2.54) than those without nonobstetric surgery after adjustment for socioeconomic deprivation, hospital level, and other comorbidities. Surgery performed in the third trimester was associated with a significantly increased rate of prematurity (aOR: 1.38; 95% CI: 1.03–1.85), but lower rates of stillbirth (aOR: 0.1; 95% CI: 0.01–0.75) and Apgar score <7 at the 5th minute (aOR: 0.2; 95% CI: 0.05–0.82), than surgery performed in the first trimester.Conclusions: Pregnancies with nonobstetric surgery during gestation were associated with increased risks of prematurity, low birth weight, low Apgar scores, neonatal and infant death, longer admission, and higher medical expenses than those without surgery. Furthermore, surgery in the third trimester was associated with a higher rate of prematurity than surgery performed in the first trimester.Trial registration: Not applicable