bluuebunny/crossref_metadata_2025 huggingface dataset:
Antitumor effects of vitamin B12 in vitro, in vivo, in silico
Authors: Gromova O. A. , Frolova D. E. , Torshin I. Yu. , Filimonova M. V. , Sorokina M. A. , Reyer I. A. , Limanova O. A. , Fedotova L. E. , Maiorova L. A.
Published: April 2024

Objective: to investigate the antitumor effects of various forms of vitamin B12 in combination with various synergistic vitamins and evaluate the prospects for clinical applications.

Material and methods. Cell lines BT-474 (breast ductal carcinoma) and A549 (lung carcinoma) were used as an in vitro cell model, and transplantable epidermoid Lewis lung carcinoma (LLC) was used as an in vivo animal tumor model. Animal studies of LLC were carried out on 25 male F1 hybrid mice (age 2.5–3 months, body weight 23–26 g). In silico research was conducted as a systematic computer analysis of 9,326 scientific sources.

Results. In vitro studies on cultures of two human tumor cell lines (BT-474 and A549) confirmed the cytotoxic effect of vitamin B12 (aquacobalamin). It has been shown that vitamin B12 has weak cytotoxic properties in the concentration range of 3.125–200 μg/L (IC50>200 nM), and its hydrophobic derivative (heptamethyl cyanoquacobyric acid ester) significantly reduces the survival of tumor lines. BT-474 and A549 cells at high concentrations (100–200 µg/l, IC50~100 nM). Experimental animals with an in vivo LLС model easily tolerated a drug based on vitamin B12. Exposure to the drug up to the 21st day of LLС development was accompanied by an increasing tendency to inhibit tumor growth by 10–20% (р=0.059). The results of a systematic in silico review of the literature show that clinical data confirmed the significant antitumor effect of vitamin B12.

Conclusion. The cellular model indicated the antitumor properties of vitamin B12 and its hydrophobic derivative. With subchronic intragastric administration of B12 to tumor-bearing animals, a steady tendency to inhibit the LLС growth was observed. Analysis of clinical data confirmed the feasibility of the antitumor use of vitamin B12 individually and in combination with synergistic vitamins.
The efficiency of thermal protection of ICE pistons with the micro-arc oxidation
Authors: Dudareva Natalia Yu. , Kolomeichenko Alexander V. , Kisel Yury E.
Published: April 2024

BACKGROUND: In order to protect pistons of internal combustion engines (ICE) from burnout and increase their durability, it is reasonable to use ceramic coatings formed on the piston head with micro-arc oxidation (MAO). Many scientific papers have been devoted to the study of the efficiency of these coatings. However, most of these studies were carried out at laboratory facilities simulating the engine operation, generally, not taking into account the real thermophysical parameters of the MAO coating. Therefore, the thermal protection efficiency of these coatings is difficult to assess.
AIM: Study of efficiency of the thermal protection of pistons using a ceramic coating formed by micro-arc oxidation on the piston head with numerical simulation.
METHODS: The study was conducted in the SolidWorks Simulation software. Two piston aluminum alloys were used as the piston material: AK12d (with a silicon content of 12%) and AK4-1 (with a silicon content of 0.35%). Temperature loads corresponding to the operation of a real engine were applied to the surfaces of the model piston. At the first stage of the study, the thermal state of pistons made of different uncoated alloys was simulated. At the second and third stages of the study, the effect of the coating thickness on the piston thermal state was simulated. The piston material of the second study stage was the AK4-1 alloy. The piston material of the third study stage was the AK12d alloy. Ceramics, which properties correspond to the coatings properties formed with the micro-arc oxidation method on these alloys, were used as the coating material. The coating thickness varied in the range from 50 to 350 µm in increments of 100 µm. The probing method was used to determine the temperature in various areas of the piston, such as at the piston head surface at the MAO coating and under it, in the area of piston grooves, at a piston skirt and the piston head from the side of a crankcase.
RESULTS: With the simulation, it was found that:

The micro-arc coating of the piston head reduces the thermal tension of the piston regardless of the aluminum alloy chemical composition.
The efficiency of the piston’s thermal protection increases with an increase in the ceramic coating thickness and a decrease in its thermal conductivity coefficient.
The greatest heat-protecting effect is achieved by the piston made of the AK12d eutectic alloy.

CONCLUSIONS: It is found that the MAO coating at the piston head is an effective way to reduce the thermal tension of the ICE pistons. Increasing the ceramic coating thickness and a decrease in its thermal conductivity coefficient increases the efficiency of the pistons thermal protection. Reducing the thermal conductivity of the MAO coating and increasing the MAO coating thickness increases the temperature on the coating surface.
Outcomes of liver resection and transarterial chemoembolization in patients with multinodular BCLC-A hepatocellular carcinoma
Authors: Yang Jiwon , Choi Won-Mook , Lee Danbi , Shim Ju Hyun , Kim Kang Mo , Lim Young-Suk , Lee Han Chu , Moon Deok-Bog , Jung Dong-Hwan , Choi Jonggi
Published: April 2024

Backgrounds/Aims: This study aimed to compare the outcomes of liver resection (LR) and transarterial chemoembolization (TACE) in patients with multinodular hepatocellular carcinoma (HCC) within the Milan criteria who were not eligible for liver transplantation.Methods: We retrospectively analyzed 483 patients with multinodular HCC within the Milan criteria, who underwent either LR or TACE as an initial therapy between 2013 and 2022. The overall survival (OS) in the entire population and recurrence-free survival (RFS) in patients who underwent LR and TACE and achieved a complete response were analyzed. Propensity score (PS) matching analysis was also used for a fair comparison of outcomes between the two groups.Results: Among the 483 patients, 107 (22.2%) and 376 (77.8%) underwent LR and TACE, respectively. The median size of the largest tumor was 2.0 cm, and 72.3% of the patients had two HCC lesions. The median OS and RFS were significantly longer in the LR group than in the TACE group (P<0.01 for both). In the multivariate analysis, TACE (adjusted hazard ratio [aHR], 1.81 and aHR, 2.41) and large tumor size (aHR, 1.43 and aHR, 1.44) were significantly associated with worse OS and RFS, respectively. The PS-matched analysis also demonstrated that the LR group had significantly longer OS and RFS than the TACE group (PS<0.05).Conclusions: In this study, LR showed better OS and RFS than TACE in patients with multinodular Barcelona Clinic Liver Cancer stage A HCC. Therefore, LR can be considered an effective treatment option for these patients.
Obesity as a Risk Factor for the Ineffectiveness of Antiangiogenic Treatment of Neovascular Age-related Macular Degeneration
Authors: Likhvantseva V. G. , Gevorgyan A. S. , Kapkova S. G. , Rychkova S. I. , Borisenko T. E.
Published: April 2024

Purpose: evaluation of obesity as a risk factor for poor outcome (ineffectiveness) of antiangiogenic treatment of patients with neovascular AMD.

Patients and methods. Body mass index (BMI) was studied in 84 patients (92 eyes) with neovascular AMD who were treated with intravitreal injections of Eilea in a fixed mode.

Results. It was found that a poor treatment outcome in the subgroup with disease progression was associated with obesity of 1–2 degrees; the average BMI in this subgroup (with a deterioration in the morphostructural parameters of the retina) significantly exceeds the indicators of ideal respondents, for comparison: 31.5 ± 0.8 versus 28.6 ± 1.1 (p = 0.04); and the incidence of obese individuals is dominant: 72 %. At the same time, a moderate inverse reliable relationship of BMI with another risk factor — systolic blood pressure (SBP) was found. In this regard, we suggested that obesity indirectly affects the outcome of treatment, since it is “tied” to systolic blood pressure (p = 0.01). An argument in favor of this assumption is a higher correlation coefficient of SAD with the outcome of treatment. The authors hypothesized that obesity contributes to the development of hypertension by increasing the risk of poor outcome of nAMD treatment. The hypothesis explained the association of obesity with the progression of morphostructural changes in the retina in the group of non-responsents with nAMD.

Conclusion. Studies have demonstrated a causal relationship between obesity and the outcome of antiangiogenic treatment of patients with nAMD. The data obtained allow us to attribute OBESITY to moderate risk factors for a poor outcome of antiangiogenic treatment of patients with nAMD. Taking into account the fact that OBESITY is a modifiable factor that can be eliminated with certain efforts, opportunities are revealed to reduce the risk of an unfavorable outcome of treatment of patients with nAMD.
Clinical and Immunological Analysis of Retinal Pigment Epithelium Transplantation Derived from Induced Pluripotent Stem Cells under Pharmacological Immunosuppression in Rabbits
Authors: Neroeva N. V. , Balatskaya N. V. , Brilliantova A. G. , Katargina L. A. , Kharitonov A. E. , Lagarkova M. A. , Bogomazova A. N.
Published: April 2024

justification. Degenerative retinal diseases associated with retinal pigment epithelium damage are untreated and lead to irreversible vision loss. The most promising approach nowadays is considered to be the transplantation of retinal pigment epithelium differentiated from pluripotent stem cells (PSC-RPE). When testing biomedical cellular products, special requirements are placed on the animal model, which should simulate pathological changes, such as in humans, and have sufficient immunological tolerance to xenogenic human cells, enabling them to function fully. For this purpose, lines of immuno-modified or immunodeficiency animals are used, usually small rodents (rats and mice), but the small size and structure of their eyes do not allow manipulation in vitreoretinal interventions in humans. An alternative method of preventing xenotransplantation rejection in large models is pharmacological immunosuppression, under which transplanted PSC-RPE may have biological effects. However, targeted studies of the effectiveness of PSC-RPE transplantation with use of immunosuppressive therapy have not been conducted in our country, and the data of a few foreign works devoted to this problem are contraversial.

Purpose. Study of immunological reactivity in transplantation of IPSC-RPE under combined immunosuppressive therapy in rabbit experiment.

Materials and methods. The study was performed on 27 male rabbits of New Zealand albino breed, of which 24 animals underwent subretinal transplantation of induced pluripotent stem cells of retinal pigment epithelium: in the I group (12 eyes) intervention was performed in the healthy eye; in group II (12 eyes) — in the area of pre-modeled atrophy of retinal pigment epithelium. Recipients were given combined immunosuppressive therapy. Control Group — 3 intact rabbits (6 eyes). The observation period was 14, 28 and 60 days. Post-transplant evaluation was carried out using standard and specialized ophthalmological examination methods. The determination of cytokines of the immune response IL-2, IL-6, immunosuppressive factors TGF-β1, TGF-β2, TSP-1 in the serum of the blood and the vitreous body was performed by solid-phase immunosurgical enzyme analysis.

Results. Comprehensive analysis of biomicroscopy, ophthalmoscopy, optical coherent tomography, immunological studies revealed no signs of active inflammation; no local and systemic increase in the concentration of acute phase IL-6, a drop in serum IL-2 levels indicated direct effects of immunosuppressive drug combinations used in this study.

Conclusion. The use of combined immunosuppressive therapy prevented rejection of xenogenic material in rabbits and obtained evidence of safety of subretinal transplantation of IPSC-RPE suspension both in the healthy eye, and pre-induced atrophy of pigmentary epithelium.
The Mediating Role of Job Satisfaction in the Relationship Between Human Resource Management Practices and Turnover Intention
Authors: Hanifa Muhammad , Widagdo Bambang , Rumijati Aniek
Published: April 2024

Research aims: This study examines the mediating role of job satisfaction among employees of a Power Generation Company in Indonesia and its relationship with compensation, training, career development, and turnover intention.Design/Methodology/Approach: This research utilized a cross-sectional survey involving 263 respondents representing all employees. The Partial Least Square Structural Equation Model (PLS-SEM) approach was employed to analyze the data, and SmartPLS was used to process multiple independent variables and test quantitative data.Research findings: The research findings indicate that compensation and career development do not have a significant direct effect on turnover intention. However, training and job satisfaction have a significant direct impact on turnover intention. The indirect relationship reveals that career development, through the mediating variable of job satisfaction, has no significant relationship with turnover intention. However, compensation and training, through the mediating variable of job satisfaction, have a significant relationship with turnover intention.Theoretical Contribution/Originality: The current study aims to expand on the existing literature by examining job satisfaction as a mediating variable between HRM practices (compensation, training, and career development) and employees' intention to leave (turnover intention).Practitioners/Policy Implications: Companies must provide satisfactory employee job satisfaction, as job satisfaction is a key mediating factor in the relationship between compensation and training that can influence turnover intention.Research Limitations/Implications: The practical implications of this study suggest that companies should strive to retain their employees by ensuring their well-being. The research findings indicate that providing employees with more training and certifications may increase their likelihood to seek opportunities at other companies. This outcome aligns with the human capital theory, as the knowledge, competence, and skills acquired by employees become inherent qualities associated with the employees themselves.
The Role of Perceived Organizational Support (POS) and Employee Satisfaction to Enhance Employee Engagement: Does Gender and Tenure Matter?
Authors: Eviana Nova
Published: April 2024

Research aims: The research investigated the conjecture that employee engagement is notably intensified in the presence of perceived organizational support (POS) and employee satisfaction. Additionally, the study explored the discrete impacts of the interconnections between these variables, considering gender and employee tenure. Design/Methodology/Approach: This study employed primary quantitative research methods through cross-sectional surveys. The hypotheses were tested using SEM-PLS with the assistance of Smart PLS.Research findings: The findings unveiled that POS indirectly influences employee engagement through its effect on employee satisfaction. Furthermore, employee satisfaction directly and positively contributes to heightened employee engagement. Neither gender nor tenure exhibits identifiable effects on the correlations between the constructs. It is ascertained that POS holds a higher degree of significance in cultivating employee engagement.Theoretical Contribution/Originality: The study empirically confirmed the enhanced employee engagement through POS and employee satisfaction, elucidating the mediating role of satisfaction, highlighting the significance of POS, and offering actionable managerial insights for human resource strategies.Practitioners/Policy Implications: It is recommended that managerial efforts be directed toward formulating human resource strategies that amplify POS.Research Limitations/Implications: Limited number of respondents due to the period of COVID-19 recovery.
Sectoral Herding During Global Rare Events: Evidence from the Indonesian Capital Market
Authors: Hariyanto Dedi , Brahmana Rayenda Khresna , Wendy Wendy
Published: April 2024

Research Aims: This research aims to examine the effects of increased levels of herding on abnormal returns during rare events.Design/Methodology/Approach: Time series regression including all stocks across 9 sectors in the Indonesia Stock Exchange from 1997 to 2020, totaling 5,615 observations is used. The primary model is predicated on three factors derived from Fama-French and prospect theory to incorporate herding as a primary risk factor in assessing the impact of on abnormal returns during rare events.Research Results: The results show that various events produce impacts on herding behavior across different sectors. During bearish market conditions, this behavior manifests significant negative effect leading to greater abnormal returns. Conversely, positive and significant anti-herding behavior is observed in bullish market conditions. Rare events do not necessarily induce herding behavior but may lead to anti-herding behavior.Theoretical Contribution/Originality: In this research, the variables are developed from the Efficient Market Hypothesis, Capital Asset Pricing Model, prospect theory, and market integration theory. The estimation model is grounded in prospect theory and the contribution addresses the research gaps.Practitioners/Policy Implications: The provision of insights to stakeholders in the capital market regarding the impact of rare events on financial behaviors influences investors' decision-making processes in stock investments.Research Limitations/Implications: The measurement of herding refers to Chang et al. (2000) due to the availability of aggregate data from the Indonesian Stock Exchange. Comprehensive micro-level data is not unavailable and the accessibility of complete micro-level data can be conducted. The presence of these data in the capital markets of other countries should be investigated.
The Effectiveness of e-Recruitment Adoption: A TAM Approach Examining User Perspectives
Authors: Sathyanarayana S. , Mohanasundaram T. , Shanthi D. , Rajendra P.
Published: April 2024

E-recruitment and its effective implementation is necessary for organizations that focus to channelize hiring, reduce costs, and attract a diverse talent pool in the present era. It is vital to understand and analyse the adoption of e-recruitment websites by job-seekers in India by focusing on factors like perceived usefulness, perceived enjoyment, and perceived ease of use. The main goal of this study is to establish the relationship between these antecedents and the user acceptance of e-recruitment in the Indian context. This cross-sectional study with descriptive research design used purposive sampling. The responses on pre-tested research instrument was collected from 612 respondents that validated the degree of relationship among the chosen factors. Perceived ease of use and pleasure positively correlated with perceived usefulness. Perceived usefulness positively impacts e-recruitment website usage. This research examined job-seekers’ acceptance of online recruiting using the Technology Acceptance Model (TAM). This study is beneficial for Human Resource (HR) recruiters, research scholars, HR professionals, job seekers, manpower consultants, and those who use technology to recruit employees. The study found that perceived enjoyment and perceived usefulness of the technology were two major drivers of job-seekers attitude towards adoption of e- recruitment websites in India at (p<0.001). The research would assist decision-makers understand recruiting website adoption antecedents. The widespread adoption of this technology will help in economizing for both firms and job-seekers, apart from knowing the job-seekers behavioural intent to adopt internet recruitment websites.
Περιγεννητικό κάπνισμα και νοσηλεία στη μονάδα εντατικής νοσηλείας νεογνών
Authors: Βλάχου Μαρία , Διαμάντη Αθηνά
Published: April 2024

Η κατανάλωση καπνού στην περιγεννητική περίοδο αποτελεί μείζον πρόβλημα δημόσιας υγείας. Αποτελεί βασικό παράγοντα
κινδύνου για δυσμενή έκβαση της κύησης και επιπλοκές του τοκετού και επηρεάζει αρνητικά την υγεία της μητέρας και του
νεογνού, με αποτέλεσμα να είναι πολλές οι περιπτώσεις που η νοσηλεία στη ΜΕΝΝ είναι αναπόφευκτη.
Η δευτερογενής και τριτογενής έκθεση των παιδιών στον καπνό του τσιγάρου τους στερεί το ανθρώπινο δικαίωμα στην υγεία
και την ευημερία. Για το λόγο αυτό είναι επιτακτική ανάγκη η προσθήκη υπηρεσιών διακοπής καπνίσματος στην περιγεννητική
φροντίδα.
Η οργάνωση ομάδων παρέμβασης για τη διακοπή καπνίσματος από επαγγελματίες υγείας ειδικά εκπαιδευμένους σε τέτοιου
είδους παρεμβάσεις και η συμμετοχή της καπνίστριας μητέρας, αλλά και του καπνιστή πατέρα σε αυτές, αποτελούν το μέσο
για τη διασφάλιση της υγείας των ίδιων, αλλά και των απογόνων τους. Αυτό έχει ως αποτέλεσμα τη μείωση της νοσηλείας στη
ΜΕΝΝ και τη διατήρηση του οικιακού περιβάλλοντος ελεύθερο από τον καπνό του τσιγάρου.
Исследование взаимосвязи мотивации профессиональной деятельности я-концепции у фрилансеров
Authors: Занин Д.С. , Борисенко Д.А.
Published: April 2024

В данной статье посредством теоретического анализа рассмотрены понятия фриланс, мотивация профессиональной деятельности и Я-концепция, а также взаимосвязь между ними, представлен обзор эмпирических исследований мотивации профессиональной деятельности среди фрилансеров. Также представлены эмпирические результаты исследования особенностей мотивации профессиональной деятельности и Я-концепции среди 80 респондентовфрилансеров со стажем фрилансерской работы от 2-х и более лет.
Влияние цифровизации образования на развитие психических процессов учеников
Authors: Ленинская Ю.В.
Published: April 2024

Цифровизация образования достаточно новый процесс. Влияние его на развитие личности ребенка все еще не до конца изучено учеными. В данной статье рассмотрено как именно сказывается цифвровизация образования на такие психические процессы как мышление, внимание, восприятие и память. Даны их определения и показаны положительные и отрицательные аспекты цифровой трансформации образования. В статье представлены результаты научного исследования, выполненного в рамках курсовой работы по теме «Цифровизация образования, как условие развития личности ребенка».
Влияние дискуссионной настольной игры «Бункер» на коммуникативные способности участников педагогического отряда
Authors: Слабожанина Е.О. , Дворцова Е.В.
Published: April 2024

В данной статье рассматривается вопрос о влиянии дискуссионной настольной игры «Бункер» на коммуникативные способности участников педагогического отряда. Рассмотрены разные подходы к понятиям: «коммуникативные способности», «коммуникабельность», «коммуникативный контроль».
Особенности становления и понимания «служения государству» в истории россии
Authors: Стетюха З.Е. , Лесникова Г.Н.
Published: April 2024

В статье исследуется становление понятия «служение государству» в мировой и российской истории, выделяется сущность термина и характерные особенности в понимании в русском менталитете
Возникновение студенческого спорта в России
Authors: Кадыров И.Р. , Мещеряков С.В.
Published: April 2024

В статье рассматривается история возникновения студенческого спорта в России, его развитие от низовых студенческих организаций до всесоюзных студенческих объединений. Обозначается актуальность изучения истории спорта, и влияние спорта на жизнь студентов. Подробно описаны основные этапы развития студенческого спорта в первой половине XX века. Также в статье описаны взаимосвязи спорта, спортивных организаций с государством СССР и Российской Империей
Специфические и вторичные стилевые признаки научной речи
Authors: Брагина О.А. , Малышева Ю.А.
Published: April 2024

Тема статьи «Специфические и вторичные стилевые признаки научной речи» относится к специальному разделу языкознания – функциональной стилистике. В настоящее время проблема выявления специфических признаков научной речи находится в центре внимания не только лингвостилистики, но и актуальна среди специалистов самых различных отраслей науки о языке. Предметом изучения являются специфические и вторичные стилевые признаки научной речи. Авторы анализируют существующие черты научного стиля, выделяют их особенности и способы выражения в тексте. Описанные в статье основополагающие теоретические аспекты, а также основные характеристики научного стиля имеют универсальный характер и могут применятся для анализа любых научных работ. Данная статья может быть интересна специалистам-филологам, а также студентам языковых вузов, занимающимся анализом функциональных стилей.
Первая битва на Алтае в эпосе «Манас»
Authors: Эшиев А.М.
Published: April 2024

В статье рассматривается первая битва кыргызов на Алтае против алтайских калмыков. Байгур хан – шестой прапрадед кыргызских родоплеменных структур. Отправка Жакыпом гонца-вестовика к кыргызским племенам на подмогу. Первое боевое крещение подростка Манаса и боевой клич ―Манас‖. Скоротечная битва и победа кыргызских воинов над алтайскими калмыками.
On the issue of some features of the use and directionality of allusion
Authors: Karchava O.V.
Published: April 2024

This article presents a scientific description of allusion as a linguistic phenomenon. The structure of allusion, its difference from a single reference, methods of implementation and direction are analysed. The role of markers of allusion, the importance of accessibility of the material to which the allusion is made, and the connection of allusion with knowledge of cultural information are also considered. Two ways of implementing allusion have been identified - nomination and quotation. The article emphasizes that, unlike other figurative means of artistic representation, allusion requires a certain degree of knowledge of the connections between the described objects.
Поликультурное воспитание младших школьников во внеурочной деятельности
Authors: Давыдова Н.А.
Published: April 2024

В статье рассматриваются особенности воспитания поликультурной личности младшего школьника во внеурочной деятельности. Проведенный анализ заявленной проблемы показывает, что необходимо осмысление такого понятия, как «поликультурное воспитание младшего школьника»; изучение традиций и обычаев региона и страны. Важно учитывать, что яркие эмоциональные переживания у младших школьников надолго сохраняются в памяти, превращаются в мотивы и стимулы поведения, способствуют выработке убеждений, навыков и привычек поведения, а это необходимо учитывать при разработке и проведении воспитательного мероприятия в рамках обновленного ФГОС НОО.
Основные аспекты организации и проведения занятий по бегу на средние дистанции в институте физической культуры, спорта и туризма петрозаводского государственного университета
Authors: Киселев В.А.
Published: April 2024

В статье рассмотрены основные моменты при обучении студентов института физической культуры, спорта и туризма ПетрГУ бегу на средние дистанции. Выделены организационные моменты, связанные с обучением. Обозначены основные ошибки, которые проявляются в процессе обучения.
Правовое регулирование профессиональной деятельности педагога-психолога
Authors: Ковтун Е.А. , Удалов Д.Э.
Published: April 2024

В статье рассматриваются вопросы правового регулирования профессиональной деятельности, педагогического работника, выполняющего трудовые функции в области психологического сопровождения образовательного процесса. Анализируются положения нормативно-правовых актов, в частности профессиональных стандартов, устанавливающих трудовые функции специалистов в области психологического сопровождения и помощи участников образовательной деятельности.
Организация стажировок студентов в рамках социального партнерства вуза и предприятия в Свердловской области
Authors: Мичурова Н.Н. , Мичуров Н.С. , Мирошин Д.Г.
Published: April 2024

Статья посвящена проблеме организации и осуществления корпоративного обучения студентов в рамках стажировочной деятельности в условиях социального партнерства вузпредприятие. Описываются три этапа организации корпоративного обучения в рамках стратегии «Школа-Вуз-предприятие» и место стажировок студентов вузов в этой стратегии. Приводится описание опыта организации и осуществления стажировок студентов Уральского Федерального университета на предприятии ОАО «Униматик».
Методические основы формирования функциональной грамотности учащихся 5-6 классов на уроках математики
Authors: Перевощикова Е.Н. , Романюк Е.С.
Published: April 2024

В данной статье рассматривается возможность формирования функциональной грамотности у обучающихся 5-6 классов при изучении математики. Выделены методические основы построения практико-ориентированных задач. Рассмотрен пример кейс-задания «Объем прямоугольного параллелепипеда», который может использоваться как для формирования, так и для оценки функциональной грамотности обучающихся. Показана необходимость построения сюжета задачи, знакомого и понятного ученикам, позволяющего установить связь между учебным материалом и его применением в жизни.
Профилактика дисграфии у детей с нарушениями устной речи с использованием приемов изобразительной деятельности
Authors: Тадевшева А.О. , Метелева О.О.
Published: April 2024

В данной статье дано описание проведения работы по профилактике дисграфии у детей с нарушениями устной речи с использованием приемов изобразительной деятельности. Здесь раскрываются взаимосвязь навыков письма и изобразительной деятельности, критерии развития этих навыков. В статье рассматриваются приемы, методы, техники, используемые в работе, а также примерные упражнения.
Человек, его внутренний мир, начало и конечная цель процесса развития цивилизации
Authors: Феуерман В.В.
Published: April 2024

Рассмотрена одна из главенствующих ценностей нравственного воспитания, в рамках процесса формирования личности, который длится всю сознательную жизнь человека – Гуманизм. Отмечено, что в основу воспитательного процесса должна быть положена личная деятельность ученика, и всѐ искусство воспитателя должно сводиться только к тому, чтобы направлять и регулировать эту деятельность. Указана роль учителя, который должен является, с психологической точки зрения, организатором воспитывающей среды.
On the issue concerned with professional-oriented foreign languages teaching at non-linguistic faculties
Authors: Akhmedova A.K.
Published: April 2024

The given article dwells on the issue concerned with professional-oriented foreign languages teaching at non-linguistic faculties. It is noted professional-oriented tuition provides for a vocational orientation, not only in the content of educational materials, but in activities that form professional skills either.
Technologies for the development of emotional intelligence in children with disabilities
Authors: Mikityuk I.V. , Semenyuk M.A.
Published: April 2024

This article highlights the need to use technologies for the development of emotional intelligence in working with children with disabilities. The authors present didactic games that teachers can use in structuring technologies for the development of emotional intelligence in children with disabilities.
Theoretical aspects of the future teacher’s readiness for analytical activity
Authors:   Saratov State University, Timonin Aleksandr N.
Published: April 2024

Introduction. In the realities of modern society experiencing the processes of globalization and informatization, there is an increasing demand for young professionals with the skills and abilities to analyze large amounts of information, able to make decisions based on data efficiently and quickly. Theoretical analysis. This article discusses the main features of the implementation of the analytical activity of the teacher. One of the key components of a teacher’s professional competence is analytical activity, which allows to analize, predict and evaluate the results of their work, as well as quickly respond to changes in the educational environment. Interpretations of the concept of “readiness” were analyzed, and the essence and structure of the readiness of future teachers for analytical activity were revealed. The novelty of the work lies in the revision of the structural components of the teacher’s readiness for analytical activity, corresponding to modern requirements of educational standards. The necessity of training specialists with the skills and abilities to work with data and information technologies is emphasized. Conclusion. The conclusion is formulated, according to which the formation of the future teacher’s readiness for analytical activity is a necessary factor of his or her successful professional activity, which can be carried out through the use of simulation modeling software in the educational process.
Methods and forms of education of a modern student
Authors:   Institute for Education Development Strategy, Shustovа Inna Yu.
Published: April 2024

Introduction. At present, with the priority of education in the country’s public policy, it is important to analyze existing approaches to the categories of methods and forms of education. Theoretical analysis allows us to see contradictions in the interpretation of these concepts. Comparative analysis makes it possible to identify significant guidelines for the teacher in choosing methods and forms of education in working with children, and to highlight the most significant positions. Consideration of the problem made it possible to identify various approaches to the definition of forms and methods of education, and the basis for their classification. Conclusion. The grounds for choosing methods and forms of upbringing are highlighted: the activity of the child himself, the manifestation of his subjective qualities in activities, communication in the definition and manifestation of an independent position; the interaction of a teacher with children should be of a value-semantic nature; communication with pupils and forms of interaction with them should stimulate the processes of self-education and self-development, self-awareness and selfattitude, self-realization and self-regulation; the use of methods and forms of education is important for collective formation, the formation of ties and relationships between pupils, the teacher and children, the manifestation of the common goal of joint life.
The life path of a personality: The experience of socio-philosophical conceptualization
Authors:   Saratov State University, Ivanova Dina D.
Published: April 2024

Introduction. The purpose of the study is to carry out a socio-philosophical analysis of the scientific heritage of researchers of the concept of the “life path of a personality”, to systematize the material, as well as to create a foundation for a socio-philosophical understanding of this category. Theoretical analysis. The article identifies three dimensions through which the concept under study is presented: everyday, artistic and scientific. Their specificity is determined, as well as the existing difficulties in their relationship. The main concepts of S. Buhler, S. L. Rubinstein, B. G. Ananyev are analyzed to identify significant elements of the socio-philosophical understanding of the category. Conclusion. The research uses the potential of social philosophy to comprehend the experience of scientists who have consolidated the concept of a life path in scientific discourse, as well as laid the foundation for its further understanding. Seven grounds were identified: scientific justification, integrity of the path, dynamics and consistency, heterogeneity of direction, points of beginning and end, the subject of the path, socio-historical context. The identified elements in the author’s positions allow us to talk about the chosen phenomenon from the point of view of consistency. The results obtained will allow us to continue the socio-philosophical study of the concept of the life path of a personality, which can serve as a basis for ensuring the stability of the personality of being in modern conditions.
Chernyshevsky and Napoleon III
Authors:   Lomonosov Moscow State University, Krotov Artem A.
Published: April 2024

Introduction. The image of Napoleon III in philosophical thinking of Chernyshevsky is important for the characterization of ideological struggle in the nineteenth century. Theoretical analysis. From his student years, Chernyshevsky followed the political career of Louis Bonaparte, noted his successes and personal traits. During the Second Empire in France, Chernyshevsky criticized Bonapartism, put forward an explanation of the reasons for its temporary triumph. He mentioned the worship of the peasantry before the glory combined with a famous name, the fear of anarchy and the erroneous calculations of the warring camps. The article shows how Chernyshevsky’s analysis of Bonapartism is related to the theoretical principles proclaimed in his main philosophical works. Just as Chernyshevsky himself, Napoleon III tried to rely on the theory of progress, but at the same time he assigned an important role to the government in the process of moving of society towards a better future. His ideal is an empire symbolizing order and power. Conclusion. In fact, Chernyshevsky and Napoleon III defended two diametrically opposed concepts of progress. They disagreed, first of all, on the question of how the true interests of the nation should be understood. In the question of the vitality of the empire, Chernyshevsky obviously turned out to be right.
The problem of privacy in a digital society of swarm intelligence
Authors:   Saratov State University, Shatkin Max A.
Published: April 2024

Introduction. The development of digital technologies requires the specification of the type of the emerging digital society. One of the development scenarios is the formation of a digital society of swarm intelligence. Theoretical analysis. The concept of swarm intelligence means an optimization algorithm that imitates the behavior of swarms or colonies of insects and bird flocks. Human society is characterized by the manifestation of swarm intelligence as a condition of joint organized activity, but the development of digital technologies brings swarm intelligence to a higher level. Creation of private swarms causes risks in the form of “Byzantine robot” – a hacked particle of the swarm, transmitting false information and jeopardizing the whole swarm. The solution is to incorporate elements of the economic game that support the values of honesty, cooperation and solidarity into the particle interactions. This leads to making privacy a “process” and changing its value status. Protecting privacy in swarm intelligence society has the potential to cause labor to lose its public status and acquire a private, hidden status and anonymize employment. Conclusion. The possible scenario of human society development towards the digital society of swarm intelligence can become a source of profound social changes and, above all, a rethinking of the social stratification based on the division of labor and social hierarchy in general.
Single intranasal immunization with a high dose of influenza vector protects against infection with heterologous influenza virus and SARS-CoV-2 in ferrets and hamsters
Authors: Egorov Andrej , Krokhin Artem A. , Leneva Irina A. , Korabliov Pavel , Loiteris Pavelas , Nebolsin Vladimir E.
Published: April 2024

BACKGROUND: The challenge of vaccine effectiveness against viruses that undergo constant antigenic changes during evolution is currently being addressed by updating vaccine formulations to match circulating strains. However, this approach proves ineffective if a virus undergoes antigenic drift and shift, or if a new virus, such as SARS-CoV-2, emerges and enters circulation. Hence, there is a pressing need to develop universal vaccines that elicit a T-cell immune response targeting conserved antigenic determinants of pathogens.

OBJECTIVE: To develop a vaccine candidate against influenza virus and coronavirus based on an attenuated influenza vector.

METHODS: In pursuit of this objective, we developed a recombinant influenza vector named FluCoV-N. It incorporates attenuating modifications in the ns1 and nep genes and expresses the N-terminal half of the N protein (N1-209) of the SARS-CoV-2 virus. To assess the vector’s protective efficacy against influenza, ferrets were infected with heterologous influenza A/Austria/1516645/2022 (H3N2) virus on the 25th day after a single immunization with 9.4 log10EID50 of the studied vector. To test protection against coronavirus, hamsters were immunized once with the vector at a dose of 8.2 log10EID50 and challenged with SARS-CoV-2 virus 21 days later.

RESULTS: As a result of modifications to the NS genomic segment, the constructed vector acquired a temperature-sensitive (ts) phenotype and demonstrated a heightened ability to induce type 1 interferons. It was harmless to animals when administered intranasally at high doses exceeding 8.0 log10EID50. In ferrets, a single intranasal immunization with FluCoV-N accelerated the resolution of infection caused by heterologous influenza H3N2 virus. Similar immunization in hamsters led to a 10,000-fold reduction in SARS-CoV-2 viral titers in the lungs on the second day after challenge and reduced pathology in the lungs of animals.

CONCLUSION: A single intranasal immunization with the FluCoV-N vector protected from heterologous influenza or SARS-CoV-2 viruses in ferrets and hamsters.
Dynamical Behavior of Fractional Order Breast Cancer Model: an Analytical and Numerical Stud
Authors: Ali Hegagi Mohamed ,   Department of Mathematics, Faculty of Science, Aswan University, Aswan 81528, Egypt, Rida Saad Zagloul , Yousef Ahmed Mohammed , Zaki Asmaa Sabry ,   Department of Mathematics, Faculty of Science, South Valley University, Qena, Egypt,   Department of Mathematics, Faculty of Science, South Valley University, Qena, Egypt,   Department of Mathematics, Faculty of Science, Aswan University, Aswan 81528, Egypt
Published: April 2024

In this paper, we investigate the dynamical behavior of the fractional-order breast cancer model with modified parameters. In this fractional-order model (FOM), we replaced the integer-order derivatives with the fractional-order derivatives on both sides. In physics, this means that the memory of a biological process is examined and transferred from one part to another while maintaining balance. The positivity of solutions of this FOM is proved. Also, the equilibrium points and stability of disease-free and endemic cases for this FOM are studied. Furthermore, the basic reproduction number (R0) is computed and sensitivity analysis concerning the parameters is achieved. We solve this FOM by two methods one of them gives an analytic-approximate solution called generalized Mittag-Leffler function method (GMLFM) and another method gives a numerical solution called predictor-corrector method (PCM). The simulations for the suggested model are presented to verify the obtained theoretical results.
Solution of Conformable Fractional Heat Equation Using Fractional Bessel Functions
Authors: Naamneh Almajeda ,   Department of Mathematics, Faculty of Sciences, Yarmouk Univeristy, Irbid, Jordan, Alsharif Sharifa , Rawashdeh Edris ,   Department of Mathematics, Faculty of Sciences, Yarmouk Univeristy, Irbid, Jordan,   Department of Mathematics, Faculty of Sciences, Yarmouk Univeristy, Irbid, Jordan
Published: April 2024

A second order linearly independent solution of the fractional Bessel equation is defined by utilizing the Wronskian matrix and the fractional Bessel function of the first kind of complex order. Additionally, as an application, a precise solution to a reformulated fractional type heat equation in one and two dimensions in a circular plate is produced.
Λ -Fractional Forced Van der Pol Oscillator with Horizon
Authors: Karaoulanis Dimitrios ,   School of Electrical and Computer Engineering, National Technical University of Athens, Greece, Lazopoulos Anastassios K. , Pirentis Athanassios , Lazopoulos Konstantinos A. ,   Mathematical Sciences Department, Hellenic Army Academy, Vari, Greece,   Independent Researcher,   Independent Researcher
Published: April 2024

Extending the investigation of the modified Van der Pol equation with its chaotic behaviour into the context of Λ -fractional analysis, the solutions of the Λ-fractional Van der Pol oscillator are studied under the influence of a horizon restricting the region of non-locality. The various solutions to the equation depend upon the horizon, however, the chaotic behaviour of the oscillator mainly depends upon the fractional order. A comparison of the chaotic behaviour of the various Van der Pol oscillator systems is presented.
Experimental Assessment of Oil Displacement Efficiency by Flue Gases for a Developed Reservoir in Carbonnate Formation of Urals-Volga Region
Authors: Ibragimov Ildar I. , Indrupskiy Ilya M. , Garifullina Chulpan A. , Khaliullin Timur F. , Valiullin Ilsur V. , Zalyatdinov Albert A. , Sadreeva Rauza Kh. , Burlutskiy Efim A. , Mingazutdinov Almaz N. , Remeev Marat M. , Kashapov Ildar Kh.
Published: April 2024

The paper presents the results of experimental evaluation of oil displacement efficiency by flue gas of a thermal power plant, compared to water, for a carbonate reservoir in the Ural-Volga region. The experiments were performed under two different injection schemes using an original laboratory complex for coreflood studies, with recombined reservoir oil, model of formation water, reservoir core material, and under reservoir thermobaric conditions. It has been confirmed that due to the prevailing nitrogen content and low values of reservoir pressure and temperature, flue gas is ineffective as an independent displacement agent either for injection from the beginning of reservoir development or as a tertiary method after waterflooding. Taking into account the relevance of synergy between increasing oil recovery and sequestration of industrial emissions, evaluation of flue gas injection as part of water-gas mixtures (SWAG) is recommended.
Features of the Formation of a Gas-Saturated Area During the Creation of an Underground Gas Storage in a Depleted Gas Reservoir in a Fractured-Pore Type Reservoir with an Active Aquifer
Authors: Gaysin Aydar R. , Shayahmetov Airat I. , Ponomarev Aleksandr I. , Malyshev Victor L. , Moiseeva Elena F.
Published: April 2024

Underground gas storages are an important component of reliable year-round operation of the country’s gas transportation system. The task of increasing the storage capacity is relevant both for newly created underground gas storages and for existing ones. The expansion of underground gas storage is a procedure for the sequential increase of gas volumes in the reservoir. It requires considerable time and in homogeneous formations can reach from eight to ten cycles of gas injection and production. During this period, the technological indicators of the development are stabilized, a stable transition zone is formed along the gas-water contact, and the active and buffer volumes of gas are stabilized. The main aim is in investigation of the influence of various factors on the formation of the transition zone within the gas-water contact during the creation and operation of underground gas storage in the elastic-water-pressure regime in fracture-pored reservoirs. Paper was based by Hydrodynamic computer 3D modelling. The nature of the influence of the following parameters on the volume of gas pushed into the aquifer region has been established: the angle of incidence of the formation, the values of minimum and maximum pressures in the gas-saturated part during the operation of the underground gas storage, the permeability of the matrix (intergranular) and fractures permeability.