bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicted configuration and stability of ATAD2/SOX10 complex
Authors: Lehrer Steven , Rheinstein Peter H.
Published: January 2023

Background: ATAD2, a melanoma competence factor, forms a protein complex with SOX10 that facilitates expression of SOX10 developmental target genes. The complex enables a strong transcriptional response to oncogenes such as BRAFV600E and is sufficient to endow oncogenic competence to melanocytes. This elucidation of the ADAT2/SOX10 complex structure may facilitate the development of drugs that can block complex formation.
Methods: We have used the ClusPro web server for protein-protein docking to visualize and analyze the complex and GROMACS to perform molecular dynamics simulation.
Results: ClusPro protein docking analysis demonstrates the central position of ADAT2 in the ADAT2/SOX10 complex. Molecular dynamics simulation of ATAD2 docked to SOX10 suggest that ATAD2/SOX10 is not a stable structure.
Conclusion: The central position of ADAT2 in the complex suggests that complexed ADAT2 may have the capability to modify multiple SOX10 functions, one of which allows BRAFv600e to impart increased oncogenic function to melanocytes. The results of molecular dynamics simulation imply that the ADAT2/SOX10 complex is not stable and might be disrupted by a therapeutic molecule, reducing the risk of melanoma. Knowledge of the ADAT2/SOX10 complex structure may facilitate the development of drugs that can block complex formation.
Prevalence of behavioral problems among 6-to-14-year children with asthma and without asthma
Authors: Xiang Yuanyuan , Shi Daiyu , Li Guirong , Bao Kai , Wang Ying , Li Yuanlin , Gao Wenlong , Zhang Rongfang
Published: January 2023

Background
Asthma and psychological-behavioral problems co-occur more frequently than would be expected based on chance. Several previous studies have shown that the association between childhood asthma and behavioral problems was unclear.
Methods
Three hundred and thirty seven 6-to-14-year children with asthma in a case group and 674 children without asthma in a control group, matched with age and sex in 1:2, was investigated from Gansu Provincial Maternal and Child Health Hospital. We obtained socio-demographic data on children and health-seeking caregivers. The Rutter’s Behaviour Scale for Children (Parents’ Scale) (RBSC-PS) was used to assess children’ behavioral problems. The quantitative relationship between childhood asthma and behavioral problems was evaluated with a conditional logistic regression.
Results
The overall prevalence of behavioral problems in the case group and the control group were 37.39% and 18.69% respectively, and the prevalence of type A, M, and N behavioral problems in the case group were all higher than those in the control group respectively (A:14.54% vs 10.68%; M: 6.53% vs 4.15%; N: 16.32% vs 3.86%). The results of multiple conditional logistic regression analysis showed that a statistically significant association was found between childhood asthma and behavior problems (adjusted odds ratio (aOR) = 1.46; 95% confidence interval (95%CI):1.16 ~ 1.83); The regression analysis for different types of behavioral problems showed that type A behavioral problem (aOR = 1.25;95%CI:0.91 ~ 1.71) or type M (aOR = 1.20; 95%CI:0.77, 1.88) were not associated with childhood asthma but type N behavioral problem had a statistically significant association with childhood asthma(aOR = 1.90;95%CI:1.40 ~ 2.57).
Conclusion
The type N behavioral problem was associated with childhood asthma, highlighting the importance of behavioral problem prevention for children with asthma in pediatric asthma clinics.
Early onset-caloric restriction alleviates ageing-associated steatohepatitis in male mice via restoring mitochondrial homeostasis
Authors: Chiang Chun-Hsien , Li Sin-Jin , Lin Yu-Han , Wang Pei-Yu , Hsu Pu-Sheng , Lin Shau-Ping , Chiang Ting-Chia , Chen Ching-Yi
Published: January 2023

Non-alcoholic fatty liver disease is associated with ageing, and impaired mitochondrial homeostasis is the main cause for hepatic ageing. Caloric restriction (CR) is a promising therapeutic approach to reduce fatty liver. The present study aimed to investigate the effect of early onset CR on decelerating the progression of ageing-related steatohepatitis. The potential mechanisms regarding to mitochondria were further evaluated. Eight-week-old C57BL/6 male mice (n = 21) were randomly divided into three groups, Young-AL (AL, ad libitum), Aged-AL, and Aged-CR (60% intake of AL). Mice were sacrificed at the age of 7 months (Young) or 20 months (Aged). Aged-AL mice displayed the greatest body weight, liver weight and liver relative weight among treatments. Ageing caused a great grade of steatosis, lipid peroxidation, inflammation, and fibrosis in the liver. Mega mitochondria with short, randomly organized crista were noticed in the aged liver. CR ameliorated these negative phenomena in aged liver. Ageing was accompanied with a lower level of hepatic ATP, while CR restored it. Mitochondrial-related protein expressions of respiratory chain complexes (NDUFB8 and SDHB), and fission (DRP1) were suppressed in aged liver. Proteins related to mitochondrial biogenesis (TFAM), and fusion (MFN2) were upregulated in aged liver. CR reversed the expressions of SDHB, TFAM, DRP1, and MFN2 in aged liver. To conclude, early onset CR significantly prevented the negative effect of ageing-associated steatohepatitis, including lipid peroxidation, inflammation, steatosis and fibrosis. Moreover, CR eased ageing-associated energy deficit in liver partially via maintaining mitochondrial homeostasis.
The Fuzzy Traveling Salesman problem with FuzzyEdge Weight: Formulation and A Genetic Algorithm
Authors: Dey Arindam
Published: January 2023

The traveling salesman problem is a fundamental and well knownclassical combinatorial network optimization problem in operation research,where the TSP finds a shortest path/route through a collection of n nodessuch that each and every node are visited exactly one time except for thestarting node. In TSP, the arc lengths are generally considered to representthe traveling time or traveling cost rather than geographical distance. It isnot possible to predict the exact arc length because the traveling time ortraveling cost fluctuated with payload, weather, traffic conditions and so on.Fuzzy set theory provides a new tool to handle the uncertainties in TSP. Inthis paper, we concentrate on TSP on a fuzzy network in which trapezoid fuzzynumber, instead of real number, is assigned to edge as edge weight. The gradedmean integration method of fuzzy numbers is applied to solve the additionoperation and defuzzification/ranking operation of fuzzy number. We proposea mathematical model for a TSP with fuzzy arc lengths. We present the utilityof fuzzy sets as arc length for TSP. An algorithmic technique based on geneticalgorithm is proposed for solving this fuzzy traveling salesman problem. Wehave designed a new crossover and mutation our proposed GA. We have useda numerical example to describe the effectiveness of our proposed algorithm.
Lightweight Traffic Sign Detection using Detachable Onboard Cameras
Authors: de Paula Mauricio , Jung Claudio
Published: January 2023

This paper presents a novel approach for traffic sign recognition (TSR) using off-the-shelf onboard vehicular cameras. Assuming that the camera intrinsic parameters are obtained offline, an online calibration scheme is used to estimate the extrinsic camera parameters, and Regions of Interest (ROIs) are created in the image domain based on the expected geometry and location of the traffic signs. Within theseROIs, the scale variation of the sign and background complexity are limited, allowing the development of lightweight Convolutional Neural Networks (CNNs) for TSR. Our experimental results for Brazilian traffic signs indicate that the proposed approach presents better accuracy than state-of-the-art methods at faster running times.
WITHDRAWN: Bio-modulation of poly (vinyl alcohol) crosslinked by silver and gold nanoparticles via laser ablation for wound healing utilization
Authors: Farea M. O. , Menazea Abdelrhman A.
Published: January 2023

This study aims to bio-modulate Poly (vinyl alcohol) crosslinked by silver and gold nanoparticles fabricated via one-step laser ablation. The structural, optical, and antibacterial properties of the fabricated samples were investigated via different techniques. FTIR and XRD were used to investigate the molecular structures of the polymer matrix of Polyvinyl Alcohol incorporating gold and silver (Ag-Au NPs) created by laser ablation. XRD data illustrate the semicrystalline structure of PVA, with two hump peaks at 2θ = 8.52o and 2θ = 20.17o that are decreased when loaded with Ag-Au nanoparticles at different laser ablation times. The FT-IR spectra demonstrated a variation in the intensity of various peaks compared to the spectrum of the Polyvinyl Alcohol. This suggests that PVA and Ag-Au nanoparticles interacted and complexed in semicrystalline areas. The optical energy gap (Eg) reduces from 5.55 eV to 5.00 eV during the direct transition and from 4.79 eV to 3.10 eV during the indirect transition. The cell viability value for sample S2 was 91.7 ± 5.8%, indicating that both nanocomposites are biocompatible. The values of S2, indicate that both nanocomposites are biocompatible. S2 represents the high values of the inhibition zone, which make it preferred in antibacterial applications. The results demonstrate that Polyvinyl Alcohol/metal composite materials have excellent optical and electrical properties, implying that they may be employed in energy devices.
Characterization of the complete chloroplast genome of Syringa oblata Lindl. from China and analysis of genome structures, comparative, phylogenetic relationships
Authors: Li Jing , Bai Ji-Qing , Du Shao-Bing , Meng Yi , Zhao Yi-Jun , Zhou Hui Hui , Xue Zhi-Peng , Wang Xiao-Ping , Wang Ping , Li Huai-Zhu
Published: January 2023

Syringa oblata is a flowering tree endemic to China, which has high medicinal and economic value. Comparative genomic analysis is necessary to elucidate the variation and phylogenetic relationships among Syringa species. An Illumina NovaSeq 6000 sequencing platform was used to sequence the whole genome of Syringa oblata plastomes in this study, and sequence assembly, annotation and characterization were performed by bioinformatics analysis, and a phylogenetic tree using Maximum Likelihood (ML) was constructed. A total of 155,668 bp was contained in the genome, which comprised two inverted repeats (IR) of 25,733 bp each, separated by a small single copy (SSC) region of 17,926 bp and a large single copy (LSC) region of 86 bp. There is a total GC content of 37.9% in the chloroplast genome, while the GC content in each region of SSC, LSC, and IR is 36.0%, 32.1%, and 43.2%. The genome contains 132 genes, including 88 protein-coding genes (CDS), 36 tRNA genes and 8 rRNA. There are seven protein-coding genes in the IR region, seven tRNA genes, and four rRNA genes. There was the most abundance of leucine and the least abundance of tryptophan among all amino acids. We detected 36 simple sequence repeats (SSRs) in the repeat structure analysis which included 32 mononucleotides (p1), 1 dinucleotide (p2), 1 trinucleotide (p3), 1 tetranucleotides (p4), and 1 complex nucleotide were explored, in the S. oblata chloroplast genome. In addition, we identified 50 long repeats, comprising 21 forward repeats, 28 palindromic repeats, and 1 complementary repeat. A phylogenetic analysis suggested that S. oblata (MW464119) is closely related to Syringa vulgaris (MG255768). It is anticipated that our results will be useful to further species identification, population genetic analysis, and biological research on Syringa oblata in the future.
Uncommon Medical Diagnostic Profiles in Psychiatric Settings Across South-south Nigeria
Authors: Uche Nwaopara
Published: January 2023

Medical disorders and emergencies may cause diagnostic puzzles, sometimes leading to negative patient outcomes, among mentally ill patients. The aim was to determine the uncommon medical diagnosis and their profiles among psychiatric settings in South-South, Nigeria: The study was done in centers across three states in a cross-sectional descriptive study that examined diagnostic profiles of a sample of 134 psychiatric patients that received medical care over one year (July 2021-July 2022) using questionnaires generated by the clinical team and ICD-10 medical diagnoses obtained from specialist reviews performed by consultant physicians from the medical team. Data analysis: was done using SPSS version 27. Chi-squared tests were conducted and a probability value of p < 0.05 was considered significant. The results showed that there was a preponderance of females with a frequency of 66.4% as compared to 33.6% for males. The most predominant age range was 10–19 years with 57 (42.5%) patients and 78.6% below 30 years. Most of the patients (49.25%) were married, 41.79% were single and 8.95% of participants were either separated or divorced. There was a statistically significant relationship between marital status, age, education, and medical diagnosis (X2 = 5.0, p = 0.02, X2=11.2, p = 0.00, X2 = 5.33, p = 0.02, respectively). Neurological medical conditions were the most predominant medical conditions found in the psychiatric settings used for the assessment with a value of 61.17%. while surgical co-morbidities were the least presenting diagnosis in psychiatric settings, with a value of 2.98%. Clinicians including the consultation-liaison psychiatrist, are therefore advised to have a high index of suspicion, about vulnerabilities within the diagnostic process of varied diseases, encountered in general medical or neuropsychiatric settings, to reduce diagnostic errors, mitigate morbidity and ultimately improve the outcome of the organic conditions.
Impact of COVID-19 on medical school admissions at The University of Arizona College of Medicine – Tucson
Authors: Mamaril-Davis James C. , Nguyen Mary , Yasmeh Jonathan P. , Leyva Emily , Li Ran , Wang Hongyi , Parikh Tejal
Published: January 2023

Background: The COVID-19 pandemic presented unforeseen obstacles to prospective medical students such as Medical College of Admission Test (MCAT) scheduling postponements and technical challenges during virtual interviews. Students were also faced with difficult decisions post-submission such as having to choose a program without ever visiting a school in-person.
Objective: The primary objective of the present study was to assess the effect of the COVID-19 pandemic on medical school admission preferences and application-related costs. This may also provide feedback to medical school administrators for future improvements to the application process.
Methods: A retrospective survey of the class of 2024 (Co24; non-COVID-19 cohort) and class of 2025 (Co25; COVID-19 cohort) was conducted in the Fall of 2021 via the Qualtrics online survey software. Statistical analysis incorporated the chi-square test on the Likert scale.
Results: There were 195 survey respondents: 77 students from the Co2024 and 89 students from the Co25. More students in the Co25 had to reschedule their MCAT compared to the Co24 (56.1% versus 14.3%; p <0.001). The in-person Co24 had higher travel-related expenses (>$500) compared to the Co25 who interviewed virtually (65.1% versus 2.4%; p <0.001). More students from the Co24 preferred the in-person interview format compared to the Co25 (85.7% versus 22.5%; p <0.001). Lastly, 87% of the Co24 and 24.7% of the Co25 felt they were able to gather a clear impression of the atmosphere and culture of a school from the interview trail alone (p <0.001).
Conclusion: Matriculated medical students at an allopathic medical school who applied during the COVID-19 pandemic had more pre-application hurdles when compared to prior cohorts. Students in the COVID-19 cohort, who primarily had virtual interviews, had less travel-related costs but felt more limited in their experience of a school’s culture. Despite this, however, the COVID-19 cohort still expressed a preference for virtual interviews.
A multi-objective particle swarm optimization based on maintaining dynamic population size
Authors: Yang Meilan , Liu Yanmin , Shu Xiaoli , Zhang Qian , Chen Fei
Published: January 2023

In recent decades, to efficiently solve multi-objective optimization problems, researchers have further studied and proposed many improved multi-objective particle swarm optimization algorithms, most of which adopt fixed population size. In the search process, if the population size is not set properly, it will affect the search effect of the algorithm and the calculation time will be too long. Meanwhile, these algorithms still have some challenges in balancing diversity and convergence. To deal with the above problems, a multi-objective particle swarm optimization based on maintaining dynamic population size (MOPSO-MDP) is proposed. Firstly, an improved update strategy of personal best solution and global best solution is introduced into the algorithm, which is helpful to improve its search ability and its ability to jump out of the local optimum. Then, the algorithm introduces a strategy of maintaining population growth, which can improve the quality of individuals and the diversity of the population. At the same time, a maintaining population reduction strategy is also proposed, which helps to maintain the quality of individuals in the population and avoid too long calculation time of the algorithm. Finally, the numerical experiments compare the proposed MOPSO-MDP with ten typical evolutionary algorithms on selected 22 test problems. The numerical experimental results show that the proposed MOPSO-MDP has noticeable advantages in population diversity and convergence ability on these 22 test problems.
Influence of Multiplicity on Properties of Ndx (X= 6, 7 and 8) Halide Transition Metal(Ii) Complexes of Glyoxime Ligand in Gas Phase and Aqueous Solution: Computational Assessment
Authors: LEONIE DJENDO MAZIA SUZANE , JEAN MOTO ONGAGNA , IDRICE ADJIEUFACK ABEL , Daniel LISSOUCK , CLAUDE NDOM JEAN , DÉSIRÉ BIKELE MAMA
Published: January 2023

The present paper has been focused on the ability of the glyoxime ligand to chelate to the [MX2] inorganic moieties in which M and X refer respectively to ndx transition metal(x = 6,7 and 8) and halogenated ligand(X =Br or Cl). The geometry optimizations at B3LYP/GEN level(LanL2DZ and 6-311+G (d,p) respectively for ndx transition metals (as well as halogen atoms) and for others atoms) have integrated the alteration of the multiplicity in each study media (gas phase and water). The passage from the fourth period transition metals to the sixth period ones enhances the reactivity of the complexes obtained regardless in gas phase. The metal-nitrogen bonds within higher multiplicity ndx (x=7,8) transition metal complexes are most unstable in both media. The [glyoxime ligand] ….[MX2] interaction strength increases in the following order: Fe2+< Co2+< Ni2+(3d series); Pd2+< Rh2+< Ru2+ (4d series) and Pt2+< Ir2+< Os2+ (5d series). For lower multiplicity bromide complexes exclusively, the enhancement of the donor character of the organic glyoxime ligand is promoted by its solvation except for nd6 transition metal complexes.
Imaging of brain electric field networks
Authors: Frank Lawrence , Galinsky Vitaly , Townsend Jeanne , Mueller Ralph-Axel , Keehn Brandon
Published: January 2023

The ability to image the dynamic electrical activity inside the brain tissues has profound implications for the understanding of cognition. This capability has been severely limited because of the difficulty in estimating these time-dependent volumetric fields from electroencephalography (EEG) data acquired on the surface of the skull. In this work we present the first method capable of accomplishing this with a high level of statistical evidence. The method employs a novel theory for brain wave propagation to reconstruct and map the fast-varying electric field distributions within the brain with high spatial and temporal resolution. The method is demonstrated in application to a condition of significant scientific and social importance, autism spectrum disorder (ASD), for which spatially resolved frequency dependent cognitive net- work anomalies are revealed.
Efficacy and safety of ultrasonography guided transperineal percutaneous laser ablation for treating benign prostatic hyperplasia: a randomized controlled trial
Authors: Chen Lei , Zhang Wei , Meng Zheying , Guo Qian , Cao Nailong , Xu Yanjun , Fu Qiang , Hu Bing
Published: January 2023

BACKGROUND: Transperineal percutaneous laser ablation (TPLA) has been proved a feasible and minimally invasive treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). However, the comparison with other therapeutic options, in particular transurethral resection of the prostate (TURP), the most widely used and gold standard surgical method for BPH patients, remained absent.
METHODS: Totally 51 BPH patients treated between 6/2019 and 12/2021 who had maximum urinary flow rate (Qmax) ≤15 mL/s and international prostate symptom score (IPSS) ≥8 were enrolled and randomly assigned to TURP or TPLA group at the ratio 1:1. TPLA was conducted with Esaote MyLab Twice equipped with flexible optical fiber, and TURP was performed by Olympus UES-40 SurgMaster System under standard procedure. The results were compared at 1, 3, 6 and 12 months after the operation. The efficacy endpoints included IPSS, Qmax, quality of life (QoL), European questionnaire-five dimensions (EQ-5D), residual urine volume (RUV), international index of erectile function-5 (IIEF-5) and ejaculatory dysfunction score. The safety endpoints included the incidence of complications, blood loss, visual analogue score (VAS) of pain, and catheter indwelling time.
RESULTS: The IPSS decreased by 14.17±6.13 at 3 months after TPLA, and by 13.19±5.86 after TURP (P=0.706). The complication rate of TPLA and TURP was 16% and 19.23% respectively (P=0.811).TPLA proved less Intraoperative blood loss (6.84±3.1mL,P＜0.001) and better ejaculatory protection within 6 months (P＜0.05). TURP has advantages in catheter indwelling time(P=0.012) and Qmax within 6 months(P＜0.05).
CONCLUSIONS: TPLA is comparable to TURP in the symptom relief of BPH patients, and with shorter operation time, less invasiveness and better protection, which may be more suitable for patients intolerant to TURP, or with underlying diseases such as anemia.
Role of Technology in Determining Financial Improvement in Sub Saharan Africa
Authors: Adeyemi Adeyinka Emmanuel , David Oladipo Olalekan
Published: January 2023

Due to scanty literature on the impact of technology on financial development in Sub-Saharan Africa via ICT, one can't help but wonder: how can technology influence the financial system in Sub-Saharan Africa? And which of the components of technology is a determining factor of financial development in this region? Using generalized method of moments (GMM) estimations to identify relationships between variables, this study examines the impact of technology on financial development in Sub-Saharan African countries from 2000 to 2021. By proving that fixed telephone services have an equalizing effect on financial development, the study adds to the body of knowledge on financial development. Mobile cellular subscriptions have also been shown to have a financial development equalizing effect. On the other side, secure internet servers have a negative equalizing effect on financial development. In order to focus resources into financial system growth, regulations aiming at upgrading fixed telephone services, mobile cellular subscriptions, and secure internet servers should be supported.
Integrative multi-omics analysis reveals molecular landscape associated with chronic lipid accumulation following contusive spinal cord injury
Authors: Yao Xin-Qiang , Chen Jia-Ying , Yu Zi-Han , Huang Zu-Cheng , Hamel Regan , Liu Jun-Hao , Shen Xing , Wang Yong-Er , Zeng Yong-Qiang , Huang Zhi-Ping , Lu Yan-Meng , Zhou Zhi-Tao , Liu Cui-Ting , Shi Jun-Min , Peruzzotti-Jametti Luca , Pluchino Stefano , Zhu Qing-An , Chen Jian-Ting
Published: January 2023

Lipid metabolism is a critical process that occurs in the lipid-rich spinal cord during damage and repair. Here, we integrated ultrastructural characteristics with multi-omics analysis as well as transcriptomic, untargeted, targeted proteomic, lipidomic, and N6-methyladenosine (m6A) epitranscriptomic profiling in a clinically relevant spinal cord injury (SCI) model. We observed lipid accumulation, lysosome-based autophagy of lipid droplets, and remyelination in the lesion of the chronic phase. The analysis also revealed molecular alterations associated with the enhancement of glycolysis, tricarboxylic acid cycle, and fatty acid metabolism, marked increases in triglyceride species with C16:0 fatty acyl chains, and adaptive changes in cholesterol metabolism. These changes included decreased uptake of cholesterol through Mylip upregulation, decreased synthesis through downregulation of Fdps and Hmgcs1, and increased efflux through Apoe upregulation. Among these, Mylip and Hmgcs1 are regulated by m6A methylation. Altogether, our ﬁndings revealed endogenous mechanisms in response to microenvironment changes, highlighting the potential of exploring lipid regulators for SCI treatment.
Comparison of Row Cover Systems for Pest Management in Organic Muskmelon in Iowa
Authors: Nelson Hayley M. , González-Acuña José F. , Nair Ajay , Cheng Nieyan , Mphande Kephas , Badilla-Arias Sharon , Zhang Wendong , Gleason Mark L.
Published: January 2023

Organic growers of cucurbit (Cucurbitaceae) crops in the midwestern United States have difficulty managing bacterial wilt—a fatal disease with a pathogen (Erwinia tracheiphila) that is transmitted by striped and spotted cucumber beetles (Acalymma vittatum and Diabrotica undecimpunctata howardi, respectively). Registered organic insecticides lack effectiveness, and host plant resistance is rare in commercial cultivars of many cucurbit crops. Row covers are widely used as barriers to minimize pest access, but the spunbonded polypropylene fabric covering traditional low tunnels must be removed at bloom to prevent overheating and facilitate pollination, thereby exposing the crop for the rest of the season. “Mesotunnels”—nylon mesh fabric covering 3.5-ft-high hoops—provide more space than low tunnels and mitigate overheating. In field experiments at Iowa State University (Ames, IA, USA) during 2016–18, two variations of mesotunnels—full-season tunnels [with purchased bumble bees (Bombus impatiens) added for pollination] and part-season tunnels (with covers removed for 2 weeks during bloom to provide pollinator access)—were compared with low tunnels and a noncovered treatment for organic ‘Athena’ muskmelon (Cucumis melo) production. Based on scouting results, full-season mesotunnels required no insecticides and part-season mesotunnels averaged 0.6 spray per season compared with 1.0 and 5.0 sprays per season for the low-tunnel and noncovered treatments, respectively. Incidence of pest and disease damage was zero for the full-season mesotunnels, 5% to 22% for the part-season mesotunnels, and 37% to 70% for both of the other treatments. Marketable yield for the full-season mesotunnel treatment exceeded the noncovered treatment significantly each year, and mean marketable yields were greater numerically than for the other treatments. Both mesotunnel treatments had a marketable yield that averaged more than twice that of the noncovered treatment in each year. Economic analysis (partial budget and cost-efficiency ratio) indicated that mesotunnels were likely to be more profitable in Iowa, USA, than either the low-tunnel or noncovered systems, but also that the year-to-year differential among treatments in profitability could be substantial. Additional experiments are needed to evaluate the efficacy of these integrated pest management practices and their profitability at spatial scales representative of commercial farms.
Precipitation, Temperature, and Population Structure Influence Genetic Diversity of Oakleaf Hydrangea Throughout Its Native Range
Authors: Sherwood Andrew , Alexander Lisa W. , Clark Matthew D. , Wu Xingbo , Hokanson Stan C.
Published: January 2023

Oakleaf hydrangea (Hydrangea quercifolia) is an understory shrub native to the southeastern United States. The species occupies a relatively small native range, and little is known about its demography, genetic diversity, or needs for conservation. Samples were collected from 188 plants in 73 locations throughout the species range and were genotyped using genotyping by sequencing. A structure analysis identified six genetic clusters that are geographically defined. Although these clusters are weakly differentiated, each has unique alleles. An environmental association analysis revealed that environmental variables explain 11.3% of genetic diversity, and population structure explains 13.5%. Further, 231 putative adaptive alleles were identified, most of which are correlated with precipitation-related variables, indicating that precipitation has an impact on genetic diversity in H. quercifolia. Many historically documented populations were found to be either extirpated or at risk of extirpation. The genetic clusters on the southern extent of the species range are relatively small and contain putative adaptive alleles at relatively high frequencies. These results highlight the importance of preserving representative germplasm from throughout the species range.
THE CHAMPION OF THE GRASSROOTS REVISITED
Authors: Faizi Fuad , Lukito Ratno , Fauzan Achmad Uzair
Published: January 2023

Emha Ainun Najib (Cak Nun) is a charismatic and controversial Muslim cultural leader who has a wide audience in Indonesia. Along with an ensemble band called Kiai Kanjeng, he has monthly performances in various parts of Indonesia Adding to that, they are occasionally invited by institutions, individuals, or businesses. In the New Order era, on behalf of the disadvantaged, Cak Nun’s criticisms against a highly controversial dam project in 1980–1991 showed his rebellious tendencies in the face of state and elite despotism. As a result, Rasmussen (2010) eventually refers to him as “the champion of the grassroots.” However, since his involvement in the corporation-induced mudflow of Lapindo in Sidoarjo in 2006, his stand on the grassroots has actually been doubted. However, based on his recent stage performances in several regions hit by industrially-induced environmental crises, particularly in Pati's northern Kendeng, some groups have begun to question whether the assumption that Cak Nun is “the champion of the grassroots” is still relevant. By elaborating on the ways in which various onstage and backstage stories were formed in northern Kendeng, this paper argues that Cak Nun is perceived to deliver confusing messages, resulting in the affected communities becoming more divided and fragmented.
Metode Penghafalan Qur’an Pada Pondok Pesantren Tahfizh Di Kalimantan Selatan
Authors: Rasyidi Ahyar , Karim Abdullah
Published: January 2023

Penelitian ini bertujuan mendeskripsikan metode penghafalan Al-Qur’an di Pondok Pesantren Tahfizh Al-Qur’an di Kalimantan Selatan. Pondok pesantren Tahfizh Al-Qur’an semakin eksis dan menarik perhatian masyarakat sejak menjadi sebuah lembaga formal di Indonesia di bawah Kementerian Agama, di samping sebagian pondok pesantren Tahfizh Al-Qur’an non-formal yang melaksanakan pembelajaran secara mandiri namun tetap berkomitmen untuk mencetak penghafal Al-Qur’an. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif naratif, dimana sumber data diambil dari hasil penelitian lapangan. Serta data sekunder yang diambil dari hasil penelitian yang telah dipublikasikan pada jurnal. Adapun teknik analisis data yang digunakan adalah reduksi data yang menyimpulkan hasil penelitian yang berkaitan. Hasil penelitian menyatakan bawah dari ketiga pondok pesantren tahfizh Al-Qur’an yang diteliti, maka ada beberapa metode yang dipakai. Dari ketiga pondok pesantren tahfizh Al-Qur’an yang diteliti, maka ada beberapa metode yang dipakai diantaranya yaitu metode Tikrar, metode Talqin, metode Yanbu’a, metode Halaqoh dan metode Talaqqi. Oleh karenanya metode dalam menghafal Al-Qur’an di pesantren tahfizh Al-Qur’an di Kalimantan Selatan dapat dikatakan tidak seragam. Beberapa metode yang dipakai di pondok pesantren tahfizh sering beredar dalam rangka guru-murid atau relasi antar lembaga, sebagaimana model transmisi pengetahuan di pondok pesantren pada umumnya. Di sisi lain, terdapat pondok pesantren yang mengembangkan metode menghafal yang disesuaikan dengan kondisi santri, pengasuh atau pengelola pondok pesantren yang mengembangkan metode penghafalan, demi memudahkan para santri.
Profile Dan Sejarah Pondok Pesantren Tahfizh Al-Qur’an Di Kalimantan Selatan
Authors: Rasyidi Ahyar , Yaqin Husnul
Published: January 2023

Penelitian ini bertujuan mendeskripsikan profile dan sejarah pondok pesantren tahfizh Al-Qur’an di Kalimantan Selatan. Menarik untuk dikaji oleh karena menjadi pusat pendidikan Al-Qur’an bagi anak sekolah dan bagi pembinaan akhlak siswa khususnya pada bidang Al-Qur’an. Para orang tua berkeyakinan bahwa jika anak mereka mondok di pesantren tahfizh Al-Qur’an, maka akan terjaga akhlaknya oleh Allah, terlebih dengan arus globalisasi zaman saat ini. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif naratif, dimana sumber data diambil dari hasil penelitian dan data sekunder dari hasil penelitian yang telah dipublikasikan pada jurnal, teknik analisis data yang digunakan adalah reduksi data yang menyimpulkan hasil penelitian yang berkaitan dengan (hasil observasi, dan wawancara kepada pimpinan pondok pesantren tahfizh Al-Qur’an). Hasil penelitian yaitu bahwa Pondok pesantren tahfizh Al-Qur’an di Kalimantan Selatan memiliki sejarah panjang. Bahkan, sejak pasca reformasi, kehadiran pondok pesantren tahfidz Al-Qur’an di Kalimantan Selatan mulai dilirik orang tua sebagai wadah pendidikan Al-Qur’an bagi anak-anaknya. Pendidikan atau pengajaran adalah salah satu dari sekian tradisi Al-Qur’an di Kalimantan Selatan. Pesantren tahfizh Al-Qur’an adalah salah satu model pendidikan Al-Qur’an. Kalimantan Selatan banyak pondok pesantren Tahfizh Al-Qur’an yang melaksanakan pembelajaran dan menghafal Al-Qur’an yang dilaksanakan secara intens. Antara pondok pesantren Tahfizh Al-Qur’an yang satu dengan yang lainnya memiliki keunikan/karakteristik masing-masing yang selanjutnya menjadi dinamika bagi perkembangan dan eksistensi pondok pesantren Tahfizh Al-Qur’an tersebut. Dibeberapa kabupaten/kota di Kalimantan Selatan, telah menetapkan peraturan daerah (perda) yang mengatur soal kemampuan masyarakatnya dalam membaca Al-Qur’an. Tercatat ada tiga daerah yang memiliki peraturan daerah yang khusus mengatur persoalan membaca Al-Qur’an, yaitu Kota Banjarmasin, Kab. Banjar, dan Hulu Sungai Utara.
The Use of Social Media in Learning English Writing
Authors: Puspita Dewi Aprilia Elok
Published: January 2023

As technology grows rapidly, social media has become one inseparable element of the daily life of modern society. Its impacts have spread into every aspect of human life, including education. The use of social media in teaching and learning activities has brought a new contribution to education, especially in language learning. Using social media, people from different countries can find it easier to communicate with each other to exchange or learn languages together, such as English. As a global language, English has four skills to be mastered to get to the proficiency level. They are reading, listening, speaking, and writing. Among all the four skills,  writing is considered to be the most complex one. As social media has brought much easiness and is very simple to use, utilizing social media to help the learning writing is considered to be helpful to help improve the effectiveness. Therefore, this article tried to uncover the use of social media in learning English writing.
The Psychological Factors in Learning Speaking
Authors: Sari Nur Nilam
Published: January 2023

Speaking skill is one of the essential skills in learning English. Effective communication is one of the criteria for measuring speaking success. It is important to speak fluently both inside and outside the classroom. Various factors influence the success of the practice of speaking English. One of them is psychological factors. Psychological factors are those factors that often interfere with emotional and physical health, relationships, work productivity, or life adjustment. Psychological factors as the leading root cause of students’ antipathy to speaking. Students' speaking abilities are influenced by a variety of psychological factors, including anxiety, shyness, lack of self-confidence, and lack of motivation. So students in learning need to understand their psychological conditions to control them. Additionally, in teaching, teachers must consider the condition of students by looking at their psychological factors. It means that the success of students in speaking English needs to pay attention to psychological factors.
Modernisasi dan Implikasi Pemikiran Harun Nasution terhadap Perkembangan Perguruan Tinggi Keagamaan Islam
Authors: Asngari  , Fajri Muhammad , Sugiannoor  , Yanto  , Muttaqin Muhammad Ridho , Aristya Septian , Rosyidi Ahmad
Published: January 2023

The background study was Islamic higher education in Indonesia in two decades faced stagnancy especially in developing of Islamic thought. In this era, Islamic higher education seemed the informal education institution or conventional institutions by memorizing method without deep understanding. By 1970, Harun Nasution implemented some modern Islamic education cultures. Islam which was studied by academically so as the Islamic higher education increased significant. Harun Nasution did the modernization or dynamics of Islamic thought in Islamic higher education. This study aimed to know Harun thought in modernization in Islamic higher education and its effect in developing of Islamic higher education now. This study was literature review or library research by using Harun Nasution’s books as a primary data included other books or media which related in this study such as magazine, newspaper, journal as secondary data. This study approach was history-philosophy-pedagogic approach. This study result was Harun Nasution thought still gave effect in IAIN then University at the time, moreover UIN Jakarta and PTKI in Indonesia generally. To implant the academic thought in students and academic people still started IAIN so as UIN level, it tried to change the curriculum of PTKI which normative before by using socio cultural, build the postgraduate program in IAIN Jakarta as a Islamic thought center and place of Islamic analyze academically. The steps were gave the philosophy object, kalam, and research methodology and other objects to the students in IAIN. His thought could be filled until now. The students could understand the Islamic and general knowledge. It could be proofed by the graduate who could compete appropriated their skill.
Implementasi Program Takhassus Menghafal Al-Qur’an di Sekolah Menengah Pertama Islam Terpadu Cordova Samarinda
Authors: Ayu Riska , Nisa Wahdatun , Rahmawati Indriana
Published: January 2023

This study aims to determine the implementation of the takhassus program for memorizing the Qur'an at the integrated Islamic junior high school (SMP IT) Cordova Samarinda. In this study, the researcher chose to use a descriptive qualitative approach. The subjects of this study were the principal, representatives of teaching teachers, homeroom teachers, chief coordinators and representatives of takhassus class students. Data collection techniques were through observation, interviews and documentation. The results show that the implementation of the Takhassus program for memorizing the Qur'an at SMP IT Cordova Samarinda has gone quite well, starting from the recruitment of students, learning, to the evaluation process. This can be seen through a well-thought-out planning process, which is then continued through an implementation in the classroom as a learning program and follow-up through evaluations in order to help make decisions in the future.
MONUMENTALIZAÇÃO DO SAGRADO:
Authors: Da Silva Paes Pedro Henrique
Published: January 2023

Ao refletir sobre as categorias de território e lugar a partir da concepção de patrimônio imaterial estabelecida pelo Decreto 3.551 de 04 de agosto de 2000, procuramos problematizar como o sentido de territorialidade para os povos Tariano e Tukano foi reafirmado a partir do registro da Cachoeira de Iauaretê como patrimônio imaterial brasileiro. Dessa forma, a combinação entre os objetos naturais que compõem o local e as experiências coletivas fixadas no espaço nos permitiu problematizar o processo de reafirmação identitária desses povos nativos. Assim, articulamos os sentidos de território, lugar e identidade a partir da perspectiva histórica, ou seja, estabelecendo relações entre presente e passado, permitindo o diálogo com reflexões sociológicas, antropológicas e geográficas.
DESTOMBAMENTOS NO ÂMBITO DO SPHAN:
Authors: Valença Mallorga Bruna
Published: January 2023

O objetivo deste artigo é tratar do cancelamento de tombo de dois bens preservados pelo Serviço do Patrimônio Histórico e Artístico Nacional (SPHAN): Conjunto Arquitetônico e Urbanístico de São João Marcos – Itaverá – Cidade de São João Marcos, localizado na cidade de Rio Claro, estado do Rio de Janeiro e da Igreja de Nossa Senhora do Rosário, localizada na cidade de Porto Alegre, estado do Rio Grande do Sul. Esses são os dois primeiros casos de cancelamento de tombo no âmbito do SPHAN e por conseguinte abriram precedentes sobre a discussão da perda da chancela do tombo e seus mecanismos legais.
ENTRE A RUÍNA E O RETORNO:
Authors: Hebling Alen Loureiro Mariana
Published: January 2023

Durante as décadas de existência da República Federativa Socialista da Iugoslávia, uma vasta rede de monumentos foi erguida em toda a extensão de seu território como símbolo da sua fundação como nação através da luta dos partisans e da herança histórica de colaboração entre as repúblicas independentes e as províncias autônomas. Assim, o presente trabalho busca mapear e identificar o estado atual dessas construções na República da Croácia – estado que emergiu da dissolução da Iugoslávia e cujas narrativas nacionais em voga tendem a antagonizar o seu passado socialista. Por meio de um levantamento quantitativo, buscamos analisar os esforços de preservação, as tentativas de destruição e as modificações e apropriações em torno desses espaços no contexto de afirmação de uma cultura nacional.
CONJUNTOS URBANOS TOMBADOS NO CEARÁ:
Authors: Barreto Lopes Daniel
Published: January 2023

O artigo analisa a utilização da escrita da história como atribuição de valor de testemunho histórico relacionado a conjuntos urbanos patrimonializados pelo Instituto do Patrimônio Histórico e Artísitico Nacional-IPHAN no Ceará. Partindo dos pareceres do conselho consultivo do IPHAN que ratifica a patrimonialização a nível nacional, temos como objetivo principal apontar caminhos na compreensão do processo de patrimonialização de conjuntos urbanos no estado do Ceará, entre os anos de 1978 a 2003, em sua relação com uma escrita da história baseada numa atribuição de valor de testemunho histórico. Dessa maneira, o recorte e tema nos traz reflexões sobre como a escrita da história foi instrumentalizada como forma de produção e visualização do passado.
LUGARES SAGRADOS JIRIPANKÓ:
Authors: Gueiros Lucas
Published: January 2023

Este artigo tem como objetivo descrever os lugares sagrados do território indígena como patrimônios culturais e lugares de memórias que possibilitam a socialização dos saberes, fazeres e crenças religiosas Jiripankó. Assim, partiremos do embasamento teórico em obras de autores como Ana Martins (2013), António Mendes (2012), Claudia Mura (2013), Joël Candau (2012), Lucia Velthem (2017), Maurice Halbwachs (2003), Maria Pinheiro (2017), Michael Pollak (1992), Pierre Nora (1993), Priscila Matta (2005) e Ulpiano de Meneses (2012), em consonância com as pesquisas de campo que vêm sendo desenvolvidas desde o ano de 2015, para possibilitar uma compreensão e descrição dos lugares sagrados – terreiro e poró – como patrimônios culturais do povo Jiripankó, habitante no Sertão do estado de Alagoas.
Identifying the Mechanisms and Molecular Targets of Guchang Zhixie
Pills on Ulcerative Colitis: Coupling Network Pharmacology with GEO
Database and Experiment Verification
Authors: Wang Weihao , Song Xujiao , Ding Shanshan , Chen Chunlin , Ma Hao
Published: January 2023

Objective:

This research investigates the mechanisms and molecular targets of the
Guchang Zhixie pill (GCZXP) against ulcerative colitis (UC) in silico and in vivo.

Methods:

The compounds and related targets of GCZXP were collected from the traditional Chinese
medicine systems pharmacology database. UC targets were from Gene Expression Omnibus
and GeneCards databases. Hub genes were acquired through Cytoscape. Gene ontology and Kyoto
Encyclopedia of Genes and Genomes enrichment were performed in the David database. R packages
were used to investigate the relationship between immune cells and hub genes and the diagnostic
model. AutoDock was used to verify the molecular docking of the core compounds and hub genes,
as well as nuclear factor-kappa B (NF-κB) p65 and IκBα. The hub genes and NF-κB pathway were
verified via experiment.

Results:

In GCZXP, a total of 51 active compounds were discovered. Enrichment analysis was used
to study inflammation, chemokine activity, NF-κB signalling pathway, etc. Thirteen key therapeutic
targets were involved, of which included three hub genes PTGS2, IL-1β and CXCL8. Immune infiltration
revealed that all of the 3 hub genes were positively correlated with M1 macrophages, neutrophils,
and activated memory CD4 cells, and negatively correlated with plasma cells. In the training
and validation sets, the area under the curve (AUC) of the diagnostic model developed by hub genes
reached 0.929 and 0.905, respectively, indicating a good forecasting potential. The rat experiment
proved that GCZXP significantly reduced the expressions of IL-1β, CXCL8, COX-2, and NF-κB
p65 while increasing IκBα and Bcl-2, alleviated colonic inflammatory injury and promoted ulcer
healing.

Conclusion:

GCZXP reduced the release of cytokines and regulated Bcl-2 in the treatment of UC
by inhibiting the NF-κB signalling pathway.