bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Rehabilitation Effect of Neurology Nursing on Stroke Patients with Diabetes Mellitus and Its Influence on Quality of Life and Negative Emotion Score
Authors: Yang Yanhong , Niu Guixia , Mi Qing , Hong Feifei , Zhang Guiqin
Published: March 2022

Objective. To explore and analyze the rehabilitation effect of neurology nursing on stroke patients with diabetes mellitus (DM) and its influence on quality of life and negative emotion score. Methods. In this experiment, 110 stroke patients with DM diagnosed and treated in our hospital from 2018 to 2020 were randomly selected and assigned to the study group (SG) and the control group (CG) according to different nursing methods, with 55 cases in each group. In SG, they were given neurology nursing. In CG, they were given routine nursing. The rehabilitation efficacy, quality of life, and negative emotion scores were compared between the two groups. Results. Compared with the CG, the levels of fasting blood glucose, 2 h postprandial blood glucose, and urinary microalbumin in SG were obviously better after treatment. In SG, the proportion of patients with basic recovery and significant improvement after treatment was higher, and the proportion of patients without treatment effect was significantly lower. Overall, the nursing effect of the SG after treatment was better than that of the CG. There was no striking difference in the quality of life and Morisky scores between the two groups before nursing intervention (

P
>
0.05

), but the quality of life and Morisky scores of patients in SG were obviously higher than those in CG after nursing intervention. After nursing intervention, SAS and SDS scores of patients in SG were obviously lower than those of patients in CG, and patients in SG were less affected by negative emotions. Questionnaires were used to investigate the satisfaction of patients in both groups, and the results showed that the satisfaction of patients in SG was higher (all

P
<
0.05

). Conclusion. Neurology nursing has better clinical efficacy for stroke patients with DM and has obvious rehabilitation effect. The quality of life and negative emotion score of patients are better, which is worthy of extensive clinical promotion and application.
Diagnostic Value of the Triple Combination of Serum Heparin-Binding Protein, Procalcitonin, and C-Reactive Protein in Children with Acute Bacterial Upper Respiratory Tract Infection
Authors: Yang Xiuqin , Zhang Yumei , Lin Hai , Zhong Hui , Wu Zhihui
Published: March 2022

To investigate the role of the triple combination serum heparin-binding protein (HBP), procalcitonin (PCT), and C-reactive protein (CRP) in children with acute bacterial upper respiratory tract infection (ABURTI). A total of 130 children with upper respiratory tract infection admitted to the Department of Pediatrics of Fujian Maternity and Child Health Hospital from September 2019 to January 2021 were selected as the research group. According to the results of pathogenic analysis, children were further subdivided into a bacterial infection group (n = 67) and a viral infection group (n = 63). Additionally, 65 children who underwent physical examinations in our hospital during the same period were collected and included into the control group (n = 65). All patients selected were treated with cefixime granules orally for 5 days. Serum HBP level, serum PCT level, and serum CRP level were measured by double antibody Sandwich Enzyme Linked Immunosorbent Assay (ELISA), fluorescence method, and immunoturbidimetric assay, respectively. The expression levels of the three indicators in the serum of all subjects were compared, and the receiver operating characteristic (ROC) curve was used to analyze their diagnostic value in children with ABURTI. Furthermore, according to clinical efficacy of children with bacterial infections, they were divided into a good efficacy group (markedly effective) and a poor efficacy group (effective + ineffective) to compare serum HBP, PCT, and CRP levels between the two groups. The ROC curve was drawn to analyze the value of the three indicators in predicting the curative effect in children with ABURTI. Pearson test was used to analyze the correlation among the expression of HBP, PCT, and CRP. Results showed that the expression levels of HBP, PCT, and CRP in the serum of children in the bacterial infection group were significantly higher than those in the other two groups. The positive rates of HBP, PCT, and CRP in children in the bacterial infection group were also significantly higher than those of the other two groups. The area under the curve (AUC) of the combined diagnosis of HBP, PCT, and CRP was 0.973, which was significantly higher than that of the single detection by any of the three indicators, which were 0.849, 0.819, and 0.854, respectively. The expression levels of HBP, PCT, and CRP in the serum of children in the good efficacy group were significantly lower than those in the poor efficacy group, and the AUC of the triple combination for predicting treatment efficacy was 0.959. Pearson test showed that there was a positive correlation between the serum expression of HBP, PCT, and CRP in children. HBP, PCT, and CRP were highly correlated in children with ABURTI, and their combined detection was of high diagnostic value among ABURTI patients, indicating that the three were expected to become potential indicators for efficacy prediction.
Applications of the Bell Numbers on Univalent Functions Associated with Subordination
Authors: Najafzadeh Sh. , Acu Mugur
Published: March 2022

The motivation of the present paper is to define a new subclass of univalent functions associated with the q-analogue of the exponential function and the well-known Bell numbers based on subordination structure. Furthermore, we estimate the coefficient bound and extreme points. Also, geometric properties such as convexity and convolution preserving concept are investigated.
External Therapy of Chinese Medicine for Herpes Zoster: A Systematic Review and Meta-Analysis
Authors: Wu Liu , Chen Yong , Man Tianming , Jin Long , Xu Zhangmeng , Lv Lizeyu , Luo Jian , Zhu Tianmin
Published: March 2022

Background. Herpes zoster (HZ) is a common skin disease that has a huge impact on the quality of life of sufferers. Antiviral therapy is a conventional treatment, but it still has limitations. This review evaluates the safety and efficacy of acupuncture in the treatment of HZ. Methods. We identified randomized controlled trials from multiple electronic sources (including Embase, PubMed, Cochrane, Web of Knowledge, China National Knowledge Infrastructure (CNKI), and China Biology Medicine Disc (CBM)) and reference lists of relevant articles and extracted data and assessed risk of bias (Cochrane’s Risk of Bias tool). Pooled data are expressed as standardized mean differences (SMDs), with 95% confidence intervals (CI) (random-effects model). Results. We included 15 trials (1811 participants) comparing acupuncture to medicine. Ten studies involving 1424 patients provided these data for the meta-analysis. The results showed that acupuncture as a control group had a higher clinical cure rate than Western medicine therapy (n = 1424, 95% Cl 2.19–3.14, I2 = 0%). Eleven studies used the visual analog scale (VAS), but only nine provided specific data, which we used as a continuous variable for data extraction. The meta-analysis also showed an SMD of −2.64 (n = 646, 95% CI −3.79–1.48, I2 = 97%) which showed great heterogeneity. Meta-analysis showed a significant reduction in the incidence of PHN in those who received acupuncture compared to pharmacotherapy (OR = 0.35, 95% CI 0.04–2.86, I2 = 52%) which showed moderate heterogeneity. Economic indicators suggest that acupuncture costs less and has fewer adverse reactions. Conclusions. This review compares acupuncture therapy with conventional treatment and finds that the curative effects of acupuncture are exact, with fewer side effects. However, with the risk of bias and imprecision of the studies included, a concrete conclusion is difficult to draw. Thus, well-designed, rigorous studies are warranted in the future.
Research on Financial Risk Forecast Model of Listed Companies Based on Convolutional Neural Network
Authors: Qin Weina
Published: March 2022

With the continuous improvement of China’s market economy, many listed companies enjoy the unlimited development opportunities brought by the market economy environment but are also threatened by various potential risks. They may be labeled “ST” at any time due to financial risks. The label may even end up in danger of delisting. Most companies encountered serious financial crises or even bankruptcies in the later period because they did not pay enough attention to the financial problems that occurred in the early stage and did not take effective measures to deal with the crisis in a timely manner. This is extremely detrimental to the subsequent development of the company. Therefore, more and more attention has been paid to the research on the financial risk status of enterprises. Therefore, on the basis of analyzing the financial information of listed companies, this article extracts the characteristics of listed companies and images them and uses convolutional neural networks to construct a financial risk prediction model to improve the accuracy of risk prediction. Specifically, this article also compares and analyzes the financial risk prediction models of different types of listed companies, optimizes the index system, and uses the convolutional neural network method to construct a targeted financial risk prediction model with data characteristics. The actual operation data and actual risk data of the listed companies are verified, proving that it has strong adaptive ability to face different types of data, strong operability, and high prediction accuracy.
Box-Cox Transformations and Bias Reduction in Extreme Value Theory
Authors: Henriques-Rodrigues Lígia , Gomes M. Ivette
Published: March 2022

The Box-Cox transformations are used to make the data more suitable for statistical analysis. We know from the literature that this transformation of the data can increase the rate of convergence of the tail of the distribution to the generalized extreme value distribution, and as a byproduct, the bias of the estimation procedure is reduced. The reduction of bias of the Hill estimator has been widely addressed in the literature of extreme value theory. Several techniques have been used to achieve such reduction of bias, either by removing the main component of the bias of the Hill estimator of the extreme value index (EVI) or by constructing new estimators based on generalized means or norms that generalize the Hill estimator. We are going to study the Box-Cox Hill estimator introduced by Teugels and Vanroelen, in 2004, proving the consistency and asymptotic normality of the estimator and addressing the choice and estimation of the power and shift parameters of the Box-Cox transformation for the EVI estimation. The performance of the estimators under study will be illustrated for finite samples through small-scale Monte Carlo simulation studies.
Effects of Tai Chi Exercise on Balance Function in Stroke Patients: An Overview of Systematic Review
Authors: Hu Caixia , Qin Xiaohui , Jiang Minqing , Tan Miaoqing , Liu Shuying , Lu Yuhua , Lin Changting , Ye Richun
Published: March 2022

Background. Tai chi (TC) has received increased attention in stroke rehabilitation, yet services are greatly underutilized. An increasing number of systematic reviews and meta-analyses (SRs/MAs) have begun to investigate the effects of TC on balance function in stroke patients. The aim of this current study was to systematically collate, appraise, and synthesize the results of these SRs/MAs using a systematic overview. Methods. Eight databases were searched: PubMed, Cochrane Library, Embase, Web of Science, CNKI, SinoMed, Chongqing VIP, and Wanfang Data. SRs/MAs of TC on balance function in stroke patients were included. Literature selection, data extraction, and assessment of the review quality were performed by two independent reviewers. Methodological quality was assessed by the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2), reporting quality by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and evidence quality by Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). Results. Nine SRs/MAs were included in this study. For methodological quality, what resulted in unsatisfactory methodological quality was noncompliance with critical item 4 (using a comprehensive literature search strategy) and critical item 7 (providing the list of excluded research literature). For reporting quality, what resulted in unsatisfactory reporting quality was inadequate reporting of Q1 (protocol and registration), Q8 (search), Q15 (risk of bias across studies), Q16 (additional analyses), Q22 (risk of bias across studies), Q23 (additional analysis), and Q27 (funding). For GRADE, the evidence quality was high in 0, moderate in 3, low in 11, and very low in 6. Risk of bias was the most common factor leading to downgrading of evidence, followed by inconsistency, imprecision, publication bias, and indirectness. Conclusions. TC may have beneficial effects on balance function in stroke survivors; however, this finding is limited by the generally low methodology, reporting quality, and evidence quality for published SRs/MAs.
In Silico and In Vitro Screening of Natural Compounds as Broad‐Spectrum β‐Lactamase Inhibitors against Acinetobacter baumannii New Delhi Metallo‐β‐lactamase‐1 (NDM‐1)
Authors: Vasudevan Aparna , Kesavan Dinesh Kumar , Wu Liang , Su Zhaoliang , Wang Shengjun , Ramasamy Mohan Kumar , Hopper Waheeta , Xu Huaxi
Published: March 2022

Antibiotic resistance is one of the significant problems globally; there is an increase in resistance with introducing every new class of antibiotics. Further, this has become one of the reasons for arising of new resistance mechanisms in Acinetobacter baumannii. In this study, we have screened natural compounds as a possible inhibitor against the NDM‐1 β‐lactamase enzyme from A. baumannii using a combination of in silico methods and in vitro evaluation. The database of natural compounds was screened against NDM‐1 protein, using Glide docking, followed by QM‐polarised ligand docking (QPLD). When the screened hits were validated in vitro, withaferin A and mangiferin had good IC50 values in reducing the activity of NDM‐1 enzymes, and their fractional inhibitory concentration index (FICI) was ascertained in combination with imipenem. The withaferin A and mangiferin‐NDM‐1 docking complexes were analyzed for structural stability by molecular dynamic simulation analysis using GROMACS for 100 ns. The molecular properties of the natural compounds were then calculated using density functional theory (DFT). Withaferin A and mangiferin showed promising inhibitory activity and can be a natural compound candidate inhibitor synergistically used along with carbapenems against NDM‐1 producing A. baumannii.
Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis
Authors: Zuin Marco , Trentini Alessandro , Marsillach Judit , D’Amuri Andrea , Bosi Cristina , Roncon Loris , Passaro Angelina , Zuliani Giovanni , Mackness Mike , Cervellati Carlo
Published: March 2022

Aim. To review and compare the PON-1 arylesterase activity between coronary artery disease (CAD) and non-CAD patients. Methods. Data were obtained by searching MEDLINE and Scopus for all investigations published between January 1, 2000 and March 1, 2021 comparing PON-1 arylesterase activity between CAD and controls. Results. Twenty studies, based on 5417 patients, met the inclusion criteria and were included in the analysis. A random effect model revealed that PON-1 arylesterase activity was significantly lower in the CAD group compared to controls (

SMD
=
–
0.587

,

95
%
CI
=
−
0.776

to -0.339,

p
<
0.0001

,

I

2

=
92.3
%

). In CAD patients, the PON-1 arylesterase activity was significantly higher among CAD patients without diabetes mellitus (DM) compared to those with diabetes (SMD: 0.235, 95% CI: 0.014 to 0.456,

p
=
0.03

,

I

2

=
0
%

). Conclusions. PON-1 activity is significantly lower in CAD patients, and those without DM presented a significantly higher PON-1 arylesterase activity.
Design and Implementation of a Novel Intelligent Strategy for the Permanent Magnet Synchronous Motor Emulation
Authors: Zeinoddini-Meymand Hamed , Kamel Salah , Khan Baseem
Published: March 2022

In this paper, an intelligent neural network‐based controller is designed and implemented to control the speed of a permanent magnet synchronous motor (PMSM). First, the exact mathematical model of PMSM is presented, and then, by designing a controller, we apply the wind turbine emulation challenges. The designed controller for the first time is implemented on a Arm Cortex‐M microcontroller and tested on a laboratory PMSM. Since online learning neural network on a chip requires a strong processor, high memory, and convergence guarantee, this article uses the offline method. In this method, first, for different work points, the neural network is trained by local controllers, and then, the trained network is implemented on the chip and used. Uncertainty in the parameters and the effect of load torque as challenges of control systems are applied in the proposed method, and a comparison with other methods is performed in the implementation results section.
Characterization and Optimization of Calcination Process Parameters for Extraction of Aluminum from Ethiopian Kaolinite
Authors: Kassa Adamu Esubalew , Shibeshi Nurelegne Tefera , Tizazu Belachew Zegale
Published: March 2022

The present study aimed to optimize the calcination process parameters (viz., temperature, time, and particles size) for the extraction of aluminum from Ethiopian kaolinite. The kaolinite calcination was done in the temperature of 600–700°C, time of 120–180 min, and particles size of 106–355 μm. The extraction of aluminum from calcined kaolinite was carried out at fixed acid concentration of 3 M, temperature of 80°C, liquid-to-solid ratio of 12 mL g−1, time of 120 min, and stirring speed of 700 rpm. The chemical composition of kaolinite was determined using XRF. Moreover, kaolinite, metakaolinite, and extracted aluminum were characterized by XRD, TGA, DSC, and FTIR. The XRF result of the kaolinite was mainly silicon oxide (55.76% w/w), aluminum oxide (32.02% w/w), and loss on ignition (11.17% w/w). Calcination of kaolinite produced amorphous metakaolinite due to the dehydroxylation reaction as shown by the FTIR results. Three endothermic peaks and one exothermic peak were detected in the thermal analysis of the kaolinite due to water removal, impurities decomposition, dehydroxylation reaction, and phase change from metakaolinite to spinel, respectively. The extracted aluminum proportionally increased with kaolinite calcination temperature and time. However, the extracted aluminum increased as the particles size reduced. The extracted aluminum was in the form of aluminum chloride hexahydrate and trigonal crystalline structure. The optimum values of the degree of conversion of kaolinite dehydroxylation reaction and extracted aluminum of 0.992 and 71.28% w/w were obtained at the optimum kaolinite calcination temperature of 700°C, time of 180 min, and particles size of 106 μm, respectively.
An Energy-Efficient Clustering Routing for Wireless Sensor Networks Based on Energy Consumption Optimization
Authors: Huibin Xu , Mengjia Zeng
Published: March 2022

In order to alleviate energy consumption of wireless sensor networks (WSNs), energy consumption optimization-based clustering routing (ECOR) is proposed in this paper. In ECOR, network is gridding by hexagon. And there is only a cluster head (CH) in each hexagon, which makes the distribution of CHs more even. Residual energy of nodes and distance from the centroid of hexagon are used to elect CHs. For any a CH, dynamic time slot allocation strategy is adopted to allocate time slot for its cluster members. According to status of cluster members, the duration of time slot is dynamically adjusted. In intercluster communication, the Dijkstra algorithm is used to construct the shortest path between CHs in order to shorten the distance of transmitting data. Simulation results show that the ECOR algorithm outperforms the improved-Low Energy Adaptive Clustering Hierarchy (I-LEACH) algorithm in terms of distribution of CHs and energy consumption.
Performance Optimization of CNC Machine Tool System Based on Sensor Data
Authors: Wu Yanfang , Yue Ning , Qian Kangkang
Published: March 2022

CNC machine tools have been popularized in the development of the manufacturing industry because of their high precision, high speed, high efficiency, and safe and reliable processing. The numerical control system and the measurement system of the machine tool are the key components of the modern numerical control machine tool, especially the measurement system of the machine tool, which is a prerequisite to ensure the high precision of the machine tool. The sensor is an important part of the measurement system. Sensors are devices that can sense the measurement objects within the measurement range and convert them into output signals and information according to certain rules. They are mainly used to detect the operating objects, system status, and operating environment status of the machine tool system and effectively control the normal operation of the machine tool system. Accurate and reliable information is provided. This study takes the CNC machine tool control system as the research object and studies the optimization measures of the sensor data to its performance. First, a model of the CNC machine tool control system was built based on MATLAB/Simulink, and then, based on this model, an open-loop (without sensor) and closed-loop (with speed and position sensors) control systems were built and were finally verified by simulation. The research results show that when there are sensors, the CNC machine tool control system has better stability and robustness.
Licochalcone A Promotes the Ubiquitination of c‐Met to Abrogate Gefitinib Resistance
Authors: Han Shuangze , Li Xiaoying , Gan Yu , Li Wei
Published: March 2022

Met proto‐oncogene (MET) amplification and tyrosine‐protein kinase Met (c‐Met) overexpression confer gefitinib resistance in non‐small cell lung cancer (NSCLC). The natural product Licochalcone A (Lico A) exhibits a broad range of inhibitory effects against various tumors. However, the effects of Lico A on c‐Met signaling and gefitinib resistance in NSCLC remain unclear. In the present study, Lico A efficiently overcame gefitinib‐acquired resistance in NSCLC cells by suppressing c‐Met signaling. Lico A decreased cell viability and colony formation dose‐dependently and impaired in vivo tumorigenesis of gefitinib‐resistant HCC827 and PC‐9 cells. Furthermore, Lico A induced intrinsic apoptosis and upregulated the protein expression levels of cleaved poly (ADP‐ribose) polymerase and cleaved caspase 3. Lico A promoted the interaction between c‐Met and E3 ligase c‐Casitas B‐lineage lymphoma (Cbl), which enhanced c‐Cbl‐mediated c‐Met ubiquitination and degradation. Depletion of c‐Cbl compromised Lico A‐induced c‐Met ubiquitination and its inhibitory efficacy in gefitinib‐resistant NSCLC cells. Taken together, the results suggest that Lico A is a promising antitumor agent that might be used to overcome c‐Met overexpression‐mediated gefitinib resistance in NSCLC cells.
Study on Maximal Oxygen Uptake of Respiration and Heart Rate in Exercise Training Based on Regression Equation
Authors: Liang Yongqing , Yu Qiufen
Published: March 2022

To investigate the important index of maximum oxygen uptake in evaluating cardiopulmonary function and to provide a basis for the evaluation of cardiopulmonary function for adolescents, a total of 200 healthy adolescents aged 12–14 were selected, and these 200 subjects were randomly assigned to the modeling group and the test group. In the first stage, data of 150 subjects were randomly selected, and the regression equation for VO2max was established by adding independent variables such as gender, age, height, weight, body mass index, and resting heart rate. In the second stage, the remaining 50 subjects were selected as the test group to test and evaluate the prediction effect of the prediction model. The results showed that the correlation coefficient between the measured value of maximal oxygen uptake and the predicted value was 0.983, and the significance level was 0.000, which was significantly lower than 0.01 correlation, indicating that there was an obvious concomitant relationship between the two values. The maximum oxygen uptake calculated by this equation is good and has a good application prospect.
Financial Risk Control Model Based on Deep Neural Networks
Authors: Xu Jinghong , Yang Daguang
Published: March 2022

Under the background of global economic integration, commercial banks are facing more and more complex business environment. As one of the major financial risks faced by commercial banks, liquidity risk determines and reflects the safety and profitability of bank operation. Based on joint-stock commercial banks as the research object, this paper, respectively, from the angle of the static and dynamic measurements and projections for liquidity risk and based on the current situation of four joint-stock commercial banks liquidity level study, tries to explore the change law of commercial banks liquidity risk and financial risk control of commercial bank and puts forward reasonable suggestions. In this paper, an AHP neural network model combining subjective and objective methods is proposed. This method can not only overcome the defects of the single evaluation method but also improve the data accessibility by using the qualitative data and quantitative data of AHP. In the aspect of financial risk control system, this paper tries to establish a more comprehensive and practical financial risk control model by combining the previous research of scholars, the business model process, and the experience of practical workers.
Rotablation in Patients with Advanced Renal Insufficiency through End-Stage Renal Disease: Short- and Intermediate-Term Results
Authors: Lo Wei-Jung , Chen Wei-Jhong , Lai Chih-Hung , Chen Yu-Wei , Su Chieh-Shou , Chang Wei-Chun , Wang Chi-Yan , Liu Tsun-Jui , Liang Kae-Woei , Lee Wen-Lieng
Published: March 2022

Objective. Patients with advanced renal insufficiency are at high risk of coronary artery disease (CAD) and complex lesions. Treating complex calcified lesion with rotational atherectomy (RA) in these patients might be associated with higher risks and poorer outcomes. This study was set to evaluate features and outcomes of RA in these patients. Method. Consecutive patients who received coronary RA from April 2010 to April 2018 were queried from the Cath Lab database. The procedural details, angiography, and clinical information were reviewed in detail. Results. A total of 411 patients were enrolled and divided into Group A (baseline serum creatinine <5 mg/dl, n = 338) and Group B (baseline serum creatinine ≥ 5 mg/dl through ESRD, n = 73). Most patients had high-risk features (65.7% of acute coronary syndrome (ACS), 14.1% of ischemic cardiomyopathy, and 5.1% of cardiogenic shock). Group B patients were significantly younger (66.8 ± 11.4 vs. 75.2 ± 10.7 years,

p
<
0.001

) and had more RCA and LCX but less LAD treated with RA. No difference was found in lesion location, vessel tortuosity, bifurcation lesions, chronic total occlusion, total lesion length, or total lesion numbers between the two groups. Less patients in Group B obtained completion of RA (95.9% vs 99.1%,

p
=
0.037

). There was no difference in the incidence of procedural complication or acute contrast-induced nephropathy. Group B patients had more deaths and MACE while in the hospital. The MACE and CV MACE were also higher in Group B patients at 180 days and one year, mostly due to TLR and TVR. Multivariate regression analysis showed that ACS, age, peripheral artery disease (PAD), advanced renal insufficiency, ischemic cardiomyopathy/shock, and high residual SYNTAX score were independent risk factors for in-hospital MACE, whereas ACS, advanced renal insufficiency, ischemic cardiomyopathy/shock, triple-vessel disease, and PAD independently predicted MACE at 6 months. Conclusions. Rotablation is feasible, safe, and could be carried out with very high success rate in very-high-risk patients with advanced renal dysfunction through ESRD without an increase in procedural complication.
Digital Image Art Style Transfer Algorithm and Simulation Based on Deep Learning Model
Authors: Lu Ziqi
Published: March 2022

In order to solve the problems of poor region delineation and boundary artifacts in Chinese style migration of images, an improved Variational Autoencoder (VAE) method for dress style migration is proposed. Firstly, the Yolo v3 model is used to quickly identify the dress localization of the input image, then, the classical semantic segmentation algorithm (FCN) is used to finely delineate the desired dress style migration region twice, and finally, the trained VAE model is used to generate the migrated Chinese style image. The results show that, compared with the traditional style migration model, the improved VAE style migration model can obtain finer synthetic images for dress style migration and can adapt to different Chinese traditional styles to meet the application requirements of dress style migration scenarios. We evaluated several deep learning-based models and achieved a BLEU value of 0.6 on average. The transformer-based model outperformed the other models, achieving a BLEU value of up to 0.72.
Anatomical Positions of Mesially/Horizontally Impacted Mandibular Third Molars are Significant Predictors for Distal Caries in Adjacent Second Molars
Authors: Le Son Hoang , Nguyen Nhut Minh , Nguyen Ngoc Thi-Bao , Nguyen Ly Thi-Bich
Published: March 2022

Background. Prevalence of distal caries in mandibular second molars (M2Ms) and its relationship with impacted condition of the adjacent mandibular third molars (M3Ms) have been reported in some studies. The results, however, were ambiguous because of including all impaction types and using univariate analysis for statistics. Aim. This study aimed to determine anatomical features of mesially/horizontally impacted mandibular third molars (M3Ms) that could predict distal caries in the adjacent mandibular second molars (M2Ms) using multivariable analysis. Materials and Methods. The study sample consisted of 300 digital panoramic radiographs of patients who underwent impacted M3Ms extraction. Two independent researchers collected the following variables from 446 pairs of M2M-M3M: sex, age, status of distal caries in M2Ms, mesial angulation, and Pell–Gregory classification of M3Ms. Results. The prevalence of distal caries was 50.67%. Multivariable Firth’s logistic regression analysis showed that age (β = 0.066, 95% CI = 0.023–0.113), mesial angulation (<30°: β = −1.205, 95% CI = −1.955 to −0.499; >70°: β = −0.730, 95% CI = −1.184 to −0.282), vertical position (level B: β = 2.275; 95% CI = 0.015–7.175; level A: β = 3.008; 95% CI = 0.755–7.905), and horizontal position (level II: β = 1.515; 95% CI = 0.444–2.874; level I: β = 1.423; 95% CI = 0.283–2.825) were significant variables after adjusting for sex in the final model for predicting distal caries (p < 0.05). Conclusions. In conclusion, anatomical positions of impacted M3Ms, such as mesial angulation and Pell–Gregory classification were significant predictors of distal caries in M2Ms.
Serum CTRP9 Reflects Coronary Collateralization in Nondiabetic Patients with Obstructive Coronary Artery Disease
Authors: Gao Ang , Liu Jinxing , Liu Yan , Hu Chengping , Zhu Yong , Zhou Yujie , Han Hongya , Zhao Yingxin
Published: March 2022

Aim. To explore the association between the serum C1q/tumor necrosis factor‐related protein 9 (CTRP9) and the formation of coronary collateral circulation in obstructive coronary artery disease (CAD). Methods. A total of 206 patients who underwent coronary angiography at Beijing Anzhen Hospital and had epicardial arteries with at least 95% stenotic lesion were enrolled. Blood samples were taken after an overnight fasting before the coronary angiography. Serum CTRP9 level was measured using commercial enzyme linked immunosorbent assay (ELISA) kit. The development of coronary collateralization was determined according to the Rentrop classification system. Rentrop score 0‐1 was graded as impaired or less‐developed coronary collateralization (n = 54) while the Rentrop score 2‐3 was defined as well‐developed collateralization (n = 152). Results. Serum CTRP9 level was significantly higher in well‐developed collateralization and diabetes groups (P < 0.001). To further explore the association between the CTRP9 level and coronary collateralization, the enrolled participants were divided into 3 tertiles according to the serum CTRP9 level. The prevalence of impaired coronary collateralization decreased stepwise with the increasing CTRP9 tertiles (P for trend <0.001). Multivariate regression analysis showed that the serum CTRP9 is independently associated with well‐developed collateralization, with an OR (95% CI) of 4.49 (1.75‐11.55) and 8.98 (2.75‐29.35) in the tertiles 2 and 3, respectively. The following subgroup and receiver‐operating characteristic (ROC) analysis also indicated that the diagnostic value of serum CTRP9 level for detecting the formation of collateralization persisted only in nondiabetic participants. Lastly, adding the serum CTRP9 into the baseline model could increase the diagnostic value of established model consisting of relevant factor for the discrimination of well‐developed collateralization only in the nondiabetic group (P = 0.046). Conclusions. Serum CTRP9 reflects well‐developed coronary collateralization in nondiabetic patients with obstructive CAD, and CTRP9 level ≥ 1.217 indicated a greater chance to forming well‐developed coronary collaterals.
Passivity Analysis of Fractional-Order Neutral-Type Fuzzy Cellular BAM Neural Networks with Time-Varying Delays
Authors: Ali M. Syed , Hymavathi M. , Alsulami Hamed , Saeed Tareq , Ahmad Bashir
Published: March 2022

In this paper, passivity analysis of fractional-order neutral-type fuzzy cellular bidirectional associative memory (BAM) neural networks with time-varying delays is investigated. Based on the Lyapunov–Krasovskii functional, delay-dependent sufficient conditions for solvability of the passive problem are obtained in terms of linear matrix inequalities (LMIs), which can be easily checked by using the MATLAB LMI toolbox. Finally, numerical examples are provided to show the effectiveness of the main results.
A Quantitative Study on Dream of the Red Chamber: Word‐Length Distribution and Authorship Attribution
Authors: Yu Yue , Liu Wei , Feng Ying
Published: March 2022

This paper investigates the distribution characteristics of word lengths in the Dream of the Red Chamber (DRC), measured in terms of the number of syllables or characters. The results show that the frequency distribution of words of different lengths in the DRC abides by the extended logarithmic distribution model. A comparison between the first forty, the middle forty, and the last forty chapters shows that the distribution of word lengths in these three parts does not differ significantly, which sheds light on the authorship of the novel.
A Review and Meta-analysis of the Effects of Replacing Fishmeal with Insect Meals on Growth of Tilapias and Sharptooth Catfish
Authors: Rapatsa Mmaditshaba , Moyo Ngonidzashe
Published: March 2022

The high cost of fish feed has affected the culturing of tilapias and sharptooth catfish in Africa. However, Africa is well endowed with terrestrial insects that can potentially replace fishmeal in the diets of fish. In this paper, the nutritional index, availability, and cost of selected insect meals are compared. The SOLVER function in Excel was used to formulate least-cost diets of Musca domestica, Gryllotalpa africana, Schistocerca gregaria, Macrotermes natalensis, and Gonimbrasia belina. The crude protein levels of all the insects were above 50% and met the requirements of both fish species. The essential amino acid index (EAAI) was highest in M. domestica (3.2613). Except for M. natalensis, all the insect meals met the fat requirements for tilapias and sharptooth catfish. The most available insects were S. gregaria and M. domestica. Feed value was highest in fishmeal (15.62) followed by M. domestica (15.52). A meta-analysis of the effects of replacing fishmeal with insect meal on growth performance of tilapias and sharptooth catfish was also carried out. The effect summary for the specific growth rate was significant whereas the effect summary for the food conversion ratio was not significant. The relationship between fishmeal replacement levels and response ratio showed wide scatter. It was thus not possible to determine the optimum replacement level. Musca domestica is recommended in the replacement of fishmeal.
Conduit CAR: Redirecting CAR T-Cell Specificity with A Universal and Adaptable Bispecific Antibody Platform
Authors: Borrok M. Jack , Li Yonghai , Harvilla Paul B. , Vellalore Maruthachalam Bharathikumar , Tamot Ninkka , Prokopowitz Christine , Chen Jun , Venkataramani Sathya , Grewal Iqbal S. , Ganesan Rajkumar , Singh Sanjaya
Published: March 2022

The success of chimeric antigen receptor (CAR) T-cell therapy against hematologic malignancies has altered the treatment paradigm for patients with these diseases. Nevertheless, the occurrence of relapse due to antigen escape or heterogeneous antigen expression on tumors remains a challenge for first-generation CAR T-cell therapies as only a single tumor antigen can be targeted. To address this limitation and to add a further level of tunability and control to CAR T-cell therapies, adapter or universal CAR T-cell approaches use a soluble mediator to bridge CAR T cells with tumor cells. Adapter CARs allow simultaneous or sequential targeting of multiple tumor antigens, control of immune synapse geometry, dose control, and the potential for improved safety. Herein, we described a novel CAR T-cell adapter platform that relies on a bispecific antibody (BsAb) targeting both a tumor antigen and the GGGGS (G4S) linker commonly used in single-chain Fv (ScFv) domains expressed on CAR T-cell surfaces. We demonstrated that the BsAb can bridge CAR T cells to tumor cells and potentiate CAR T-cell activation, proliferation, and tumor cell cytolysis. The cytolytic activity of CAR T-cells was redirected to different tumor antigens by changing the BsAb in a dose-dependent manner. This study highlights the potential of G4S-displaying CAR T cells to be redirected to engage alternative tumor-associated antigens (TAA).

Significance:

New approaches are needed to address relapsed/refractory disease and manage potential toxicities associated with CAR T-cell therapy. We describe an adapter CAR approach to redirect CAR T cells to engage novel TAA-expressing cells via a BsAb targeting a linker present on many clinical CAR T-cell therapeutics. We anticipate the use of such adapters could increase CAR T-cell efficacy and reduce potential CAR-associated toxicities.
Subtrigonal Inlay Patch Technique with Buccal Mucosa Graft for Recurrent Bladder Neck Contractures
Authors: Bozkurt Ozan , Sen Volkan , Demir Omer , Esen Adil
Published: March 2022

Introduction: We aimed to present a novel subtrigonal inlay patch (SIP) technique with buccal mucosa graft (BMG) for recurrent bladder neck contracture (BNC) via open approach. Materials and Methods: Surgical approach for SIP technique is described in detail and outcomes of patients who have been operated with this technique for recurrent BNC were given. Briefly, bladder neck incision is performed after vertical cystotomy, fibrotic scar tissue is excised completely, and a BMG is patched at the end. Results: All 3 patients were able to void in their first attempt after catheter removal. Follow-up durations were 14, 11, and 5 months for the patients and all 3 patients reported satisfactory voiding. No de novo urinary incontinence was reported by patients after catheter removal, and all were continent with no pad need on their last follow-up visit. None of the operated patients needed any intervention such as catheterization, dilatation, or internal urethrotomy for BNC on follow-up. Conclusion: The present study demonstrates the feasibility and promising results of SIP technique with open surgical approach. Further experience is mandatory with larger patient cohorts and longer follow-up.
Assembly of Bacillus subtilis Dynamin into Membrane-Protective Structures in Response to Environmental Stress Is Mediated by Moderate Changes in Dynamics at a Single Molecule Level
Authors: Sattler Laura , Graumann Peter L.
Published: March 2022

Dynamin-like proteins are membrane-associated GTPases, conserved in bacteria and in eukaryotes, that can mediate nucleotide-driven membrane deformation or membrane fusion reactions. Bacillus subtilis’ DynA has been shown to play an important role in protecting cells against chemicals that induce membrane leakage, and to form an increased number of membrane-associated structures after induction of membrane stress. We have studied the dynamics of DynA at a single molecule level in real time, to investigate how assembly of stress-induced structures is accompanied by changes in molecule dynamics. We show that DynA molecule displacements are best described by the existence of three distinct populations, a static mode, a low-mobility, and a fast-mobile state. Thus, DynA is most likely freely diffusive within the cytosol, moves along the cell membrane with a low mobility, and arrests at division sites or at stress-induced lesions at the membrane. In response to stress-inducing membrane leakage, but not to general stress, DynA molecules become slightly more static, but largely retain their mobility, suggesting that only few molecules are involved in the repair of membrane lesions, while most molecules remain in a dynamic mode scanning for lesions. Our data suggest that even moderate changes in single molecule dynamics can lead to visible changes in protein localization patterns.
Duplication of 12q24.21q24.33 in a Girl with Epilepsy, Expanding the Phenotype
Authors: Plaza-Benhumea Lautaro , Martin-de Saro Monica D. , Sanchez-Acosta Cesar G. , Messina-Baas Olga , Cuevas-Covarrubias Sergio A.
Published: March 2022

Introduction: Duplication of 12q is characterized by craniofacial dysmorphia, growth failure, occasional brain malformations, abnormalities of the extremities, skeletal and thoracic malformations, cardiovascular defects, anogenital abnormalities like cryptorchidism, psychomotor delay, and intellectual disability. Case presentation: We describe a female patient with typical manifestations of duplication 12q and epilepsy. She had a normal 46,XX karyotype. The microarray assay exhibited a 19.35-Mb gain at 12q24.21q24.33 due to ins(21;12)(p11.2;q24.21q24.33)mat. Discussion and Conclusion: The duplicated region in the patient encompasses 219 genes, 24 considered as pathological. No relation between epilepsy and the genes reported as pathological has been reported.
A Comparative Study of Patient-Derived Tumor Models of Pancreatic Ductal Adenocarcinoma Involving Orthotopic Implantation
Authors: Yanagihara Kazuyoshi , Iino Yuki , Yokozaki Hiroshi , Kubo Takanori , Oda Tatsuya , Kubo Takashi , Komatsu Masayuki , Sasaki Hiroki , Ichikawa Hitoshi , Kuwata Takeshi , Seyama Toshio , Ochiai Atsushi
Published: March 2022

Background: Pancreatic ductal adenocarcinoma (PDA) is associated with very poor prognoses. Therefore, new therapies and preclinical models are urgently needed. In the present study, we sought to develop more realistic experimental models for use in PDA research. Methods: We developed patient-derived xenografts (PDXs), established PDX-derived cell lines (PDCLs), and generated cell line-derived xenografts (CDXs), which we integrated to create 13 matched “trios” – i.e., patient-derived tumor models of PDA. We then compared and contrasted histological and molecular alterations between these three model systems. Results: Orthotopic implantation (OI) of the PDCLs resulted in tumorigenesis and metastases to the liver and peritoneum. Morphological comparisons of OI-CDXs and OI-PDXs with passaged tumors revealed that the histopathological features of the original tumor were maintained in both models. Molecular alterations in PDX tumors (including those to KRAS, TP53, SMAD4, and CDKN2A) were similar to those in the respective PDCLs and CDX tumors. When gene expression levels in the PDCLs, ectopic tumors, and OI tumors were compared, the distant metastasis-promoting gene CXCR4 was specifically upregulated in OI tumors, whose immunohistochemical profiles suggested epithelial-mesenchymal transition and adeno-squamous trans-differentiation. Conclusion: These patient-derived tumor models provide useful tools for monitoring responses to antineoplastic agents and for studying PDA biology.
Role of Blood Pressure Responses to Exercise and Vascular Insulin Sensitivity with Nocturnal Blood Pressure Dipping in Metabolic Syndrome
Authors: Stewart Nathan R. , Heiston Emily M. , Miller Stephanie L. , Ballantyne Anna C. , Cheema Udeyvir S. , Spaeth Andrea M. , Kokkinos Peter , Malin Steven K.
Published: March 2022

Introduction: Nocturnal systolic blood pressure (SBP) dipping is independently related to cardiovascular disease risk, but it is unclear if vascular insulin sensitivity associates with SBP dipping in patients with metabolic syndrome (MetS). Methods: Eighteen adults with MetS (ATP III criteria 3.3 ± 0.6; 53.2 ± 6.5 years; body mass index 35.8 ± 4.5 kg/m2) were categorized as “dippers” (≥10% change in SBP; n = 4 F/3 M) or “non-dippers” (<10%; n = 9 F/2 M). Twenty-four-hour ambulatory blood pressure was recorded to assess SBP dipping. A euglycemic-hyperinsulinemic clamp (40 mU/m2/min, 90 mg/dL) with ultrasound (flow mediated dilation) was performed to test vascular insulin sensitivity. A graded, incremental exercise test was conducted to estimate sympathetic activity. Heart rate (HR) recovery after exercise was then used to determine parasympathetic activity. Metabolic panels and body composition (DXA) were also tested. Results: Dippers had greater drops in SBP (16.63 ± 5.2 vs. 1.83 ± 5.6%, p < 0.01) and experienced an attenuated rise in both SBPslope (4.7 ± 2.3 vs. 7.2 ± 2.5 mm Hg/min, p = 0.05) and HRslope to the incremental exercise test compared to non-dippers (6.5 ± 0.9 vs. 8.2 ± 1.7 bpm/min, p = 0.03). SBP dipping correlated with higher insulin-stimulated flow-mediated dilation (r = 0.52, p = 0.03), although the relationship was no longer significant after covarying for HRslope (r = 0.42, p = 0.09). Conclusion: Attenuated rises in blood pressure and HR to exercise appear to play a larger role than vascular insulin sensitivity in SBP dipping in adults with MetS.