bluuebunny/crossref_metadata_2025 huggingface dataset:
A model for estimating the hydraulic conductivity of bentonite under various density conditions
Authors: Kijima Tatsuya , Sasagawa Tsuyoshi , Sawaguchi Takuma , Yamada Norikazu
Published: September 2022

Bentonite is an important material for low-permeability engineering systems used in dams and hazardous waste facilities. While models to characterize the hydraulic conductivity of bentonite have been developed in previous studies, these models were not applicable to various density conditions for Na- and Ca-bentonite. In this study, we present a new model for estimating the hydraulic conductivity of bentonite applicable to a wide range of density conditions for Na- and Ca-bentonite. In order to consider flow paths in compacted bentonite, a lamination structure of montmorillonite stacks was assumed. Our hydraulic model discriminated interlayer pores and other pores by applying a method for estimating the probability of connected pores and hydraulic coefficients governed by the plane Poiseuille flow equation. The model was consistent with the experimental data investigated in previous studies on the hydraulic conductivity of Na-bentonite and was in good agreement with the data of Ca-bentonite in the range of an effective montmorillonite density (ρem) at 500 kg/m3 ≤ ρem ≤ 1,500 kg/m3 and 600 kg/m3 ≤ ρem, respectively. However, some experimental values on Ca-bentonite under low-density conditions were far higher than the model results in the case where Ca-bentonite forms flow paths of relatively large pores.
Scaling trend of coal chemical saline wastewater in falling film evaporator: experimental solid–liquid equilibrium and numerical simulation
Authors: Li Huashan , Liu Youle , Liu Bing , Jiang Qing , Zhang You , Gao Yu , Xue Jianliang
Published: September 2022

It was important to establish the scaling mechanism to slow down scaling, which is one of the important problems faced by saline wastewater treatment with falling film evaporators. In this paper, the phase equilibrium data of ternary system NaCl-CaCl2-H2O at 303.15–373.15 K were measured, and the prediction of the flow characteristics and scaling tendency of salt-containing wastewater in the evaporation tube was investigated by numerical simulation based on the phase equilibrium results. The results showed that the mesostable phase diagram of the ternary system was of simple type, and w(NaCl) and w(CaCl2) showed regular variation with temperature when w(NaCl) in the system was 15–28%. Moreover, the components of the four saline wastewaters (10% NaCl + 9, 10, 11, 12% CaCl2) with less salt content had a faster heating and a faster rate of evaporation of the liquid film in the evaporation tube. Based on the solubility in the experiments and simulations, it was concluded that NaCl crystals were precipitated at tube lengths of 718 mm, 942 mm, 966 mm, and 1,000 mm for four salt concentrations in the evaporation process by comparison, and the reliability of the predicted loci was also demonstrated by a falling film evaporation experimental setup.
An optimisation approach for the operating rule curves of the A Vuong reservoir, Vietnam
Authors: To Thuy Nga , Vu Huy Cong , Le Hung
Published: September 2022

This paper proposes to optimise the operation of the A Vuong reservoir using the dynamic programming technique. The A Vuong is a large reservoir in Vietnam serving multiple purposes, including power generation, flood control, and downstream water supply. First, different flood control storage capacities (Vpl) are investigated, and the best one is chosen based on the criteria of power output and the reservoir's ability to fill up after each regulation cycle. That option is for Vpl to be 50, 30, and 10% of the active storage capacity in September, October, and November, respectively. The study also proposes new operating rule curves with various scenarios of different beginning water levels, ranging from 368 m to 380 m. The average lines of the operating rule curves are also suggested for easier and more efficient operation. Recommendations for using this operating rule curve, as well as its advantages compared to the current one, are also discussed. The results show that the proposed operating rule curves provide much better performance compared with the current in terms of increasing the power output, with a 3.1% increase, while also protecting other water uses.
Novel Proline Derivatives for Treating COVID-19
Authors: De Surya K.
Published: September 2022

COVID-19 is a contagious disease. Paxlovid, a combination of Nirmatrelvir
and Ritonavir, was granted emergency use authorization by the United States Food and
Drug Administration (FDA) for the treatment of COVID-19 on December 22, 2021. These
are peptidomimetic coronavirus main protease inhibitors. Nirmatrelvir is a proline derivative.
The present patent describes similar proline- like compounds, their preparation, use,
pharmaceutical composition, and treatment.
Acarbose Potentially Binds to the Type I Peptide Deformylase Catalytic Site and
Inhibits Bacterial Growth: An In Silico and In Vitro Study
Authors: Singh Atul Kumar , Prajapati Kumari Sunita , Kumar Shashank
Published: September 2022

Background:

In bacteria, peptide deformylase (PDF), a metalloenzyme, removes N-formyl methionine from a nascent protein, which is a critical step in the protein maturation process. The enzyme is ubiquitously present in bacteria and possesses therapeutic target potential. Acarbose, an FDA-approved antidiabetic
drug, is an alpha-glucosidase inhibitor of microbial origin. Clinical studies indicate that acarbose administration
in humans can alter gut microbiota. As per the best of our knowledge, the antibacterial potential of acarbose has
not been reported.

Objective:

The present study aimed to check the binding ability of acarbose to the catalytic site of E. coli PDF
and assess its in vitro antibacterial activity.

Methods:

Molecular docking, molecular dynamic (MD) simulation, and MM-PBSA experiments were performed to study the binding potential of the catalytic site, and a disc diffusion assay was also employed to assess the antibacterial potential of acarbose.

Results:

Acarbose was found to form a hydrogen bond and interact with the metal ion present at the catalytic
site. The test compound showed a better docking score in comparison to the standard inhibitor of PDF. MD
simulation results showed energetically stable acarbose-PDF complex formation in terms of RMSD, RMSF,
Rg, SASA, and hydrogen bond formation throughout the simulation period compared to the actinonin-PDF
complex. Furthermore, MM-PBSA calculations showed better binding free energy (∆G) of acarbose PDF than
the actinonin-PDF complex. Moreover, acarbose showed in vitro antibacterial activity.

Conclusion:

Acarbose forms conformational and thermodynamically stable interaction with the E. coli peptide
deformylase catalytic site. Results of the present work necessitate in-depth antimicrobial potential studies on the
effect of acarbose on drug resistance and nonresistant bacteria.
Chia Seeds Oil Suppresses the Resistance of Hepatocellular Carcinoma
Cells to Liposomal-doxorubicin and Upregulates the Tumor Suppressor
miRNAs
Authors: Awad Els T. , Tawfik Shaimaa A. , Abu Bakr Hoda O. , Ahmed Ismail M. , Ashour Esmat , Gamal-Eldeen Amira M.
Published: September 2022

Background:

Chia seed is an oil-seed of multiple biological activities. Doxorubicin is an effective chemotherapy for liver cancer. Resistance and adverse effects are doxorubicin limitations.

Objective:

This study aimed to investigate the effect of chia seeds oil (CSO) on the resistance of HepG2 cells to liposomal-doxorubicin (DOX).

Methods:

The objective were investigated through measuring cytotoxicity, doxorubicin-metabolizing enzyme Cytochrome P450 3A4 (CYP-3A4), multidrug resistance-associated protein (MRP1), and the expression of multiple tumor suppressor microRNAs.

Results:

The findings indicated that low concentration of CSO increased HepG2 cells sensitivity to DOX as concluded from its higher cytotoxicity. DOX induced mRNAs of CYP-3A4 and MRP1 and their protein levels. CSO inhibited both in DOX-treated cells. CSO induced tumor suppressor miRNAs. Doxorubicin inhibited miR-122 and let-7/b/e expression, while it led to overexpression of let-7a. CSO/DOX upregulated let-7/b/e, miR-34a, and miR-122 (which inhibits MRP1) and downregulated let-7a that may lead to increased apoptosis.

Conclusion:

CSO effectively re-sensitized HepG2 cells to liposomal-doxorubicin via inhibiting MRP1 and CYP-3A4 that may increase in vivo doxorubicin bioavailability and decrease its therapeutic dose to diminish its adverse effects.
Computational Design for Identification of Human Anti-MUC1
Heteroclitic Peptides in the Treatment of HER2-Positive Breast Cancer
through Neural Network Training and Monomeric based Design
Authors: Chhillar Anil Kumar , Behl Akanksha , Das Nagendra Nath , Sharma Krishna Kant , Sharma Namita , Gulia Prity
Published: September 2022

Aims:

Generation of human anti-MUC1 peptide through neural network training and monomeric design method. Analyzing 9-mer peptide potential computationally for treatment of HER2-positive breast cancer.

Background:

Extract human MUC1 sequences from various databases. 2. Perform neural networking method for novel peptides sequences. Analyze the potentiality of generated heteroclitic peptide sequences for suitable vaccine candidate for breast cancer treatment.

Objective:

Monomeric based design option was selected for evolutionary and physics based simulations of human anti MUC1. Neural network training, evolutionary profiling, MHC interaction values revealed two anti-MUC1 heteroclitic peptide epitopes which can induce cytotoxic T-lymphocyte response to invade tumour cells.  Alignment-independent prediction of subunit vaccine potency and allergenicity nature suggested putative anti MUC1 heteroclitic peptides.  A 9-mer in silico designed heteroclitic peptide WAVWTYVSV indicated promising values which can be utilised as tumour marker or drug delivery candidate in the treatment of human breast cancer.

Method:

Input Scaffolds of protein data base (PDB) files for human MUC1 were retrieved and loaded into Evo design server with monomeric based design option. Further, neural network training approaches were followed and other computational tools were used for alignment-independent prediction of protective antigens and subunit vaccines potency of designed heteroclitic peptides.

Result:

Study findings revealed two human anti-MUC1 heteroclitic peptides of 9mers (WAVWTYVSV, FMSFYIMNL) which showed lowest energy cluster and sequence identity (Fig. 1 and Fig. 3), normalized relative error rate of secondary structure, solvent accessibility, backbone torsion angles for neural networking (Fig. 2 and Fig. 4) and RMSD values in evolutionary profiling, online MHCPred IC50 interaction values (supplementary file-1, supplementary file-2). VaxiGen v2.0 server revealed subunit vaccine potency values of in-silico designed two heteroclitic peptides were as 0.1551 (WAVWTYVSV), 0.3508 (FMSFYIMNL) with threshold value of 0.5 followed by AllerTOP v2.0 for their allergenicity nature in immunogenic reactions (supplementary file-1, supplementary file-2).

Conclusion:

Computationally designed heteroclitic peptide WAVWTYVSV indicated promising values which can be utilised as drug delivery or tumour marker candidate in the treatment of human breast cancer by eliciting lyse of tumor cells.
Positive Expression of Paired Box 5 (Pax5) was Associated with Age,
Tumor Location, and Tumor Size of Patients with Gastrointestinal Neuroendocrine
Tumors (NETs)
Authors: Zhang Ting , Hong Fangfang , Wu Haibo
Published: September 2022

Background:

Neuroendocrine tumors (NETs) can occur in most human epithelial organs,
however, there are few studies on digestive system NETs.

Aims:

The study aims to analyze Pax5 expression in digestive tract NETs and discuss its diagnostic significance.

Methods:

This study included 64 cases of NETs diagnosed from 2019 to 2020. Expressions of paired box
5 (Pax5), CD56, synaptophysin (Syn), and chromogranin (CgA) were detected using the immunohistochemical
assay. Clinicopathological parameters, including tumor location, histological classification,
depth of infiltration, tumor diameter, lymph node metastasis, vascular tumor thrombus, and nerve invasion,
were determined in Pax5 positive and negative patients. Spearman correlation analysis was performed
to analyze the correlation between Pax5 and CD56, Syn, and CgA.

Results:

The positive rate of Pax5 expression in patients with NETs was 46.9% (30/64). There were more
patients ≥60 years illustrating positive expression of Pax5 compared to those patients <60 years
(χ2=8.438, P=0.004). There were significant differences in histological classification between Pax5 positive
expression patients and Pax5 negative expression patients (χ2=17.639, P=0.011). Significant Pax5
positive expression patients demonstrated tumor size ≥3 cm, compared to Pax5 negative expression patients
(χ2=6.764, P=0.009). Therefore, positive Pax5 expression was related to age, histological classification,
and tumor size of NETs patients. Pax5 expression in digestive system NETs was not correlated with
CD56 (χ2=0.233, r=0.024, P=0.853), Syn (χ2=0.635, r=0.047, P=0.715), CgA (χ2=2.346, r=0.170,
P=0.179).

Conclusions:

Positive expression of Pax5 was related to age, tumor location, and tumor size of NETs patients.
Pax5 can be used in combination with common immune markers (CD56/Syn/CgA) and can improve
the diagnostic accuracy of digestive system NETs.
Effect of Mesioangular Impaction of the Mandibular Third Molars on the
Adjacent Mandibular Second Molars: An Imaging Study
Authors: Liu Liuhui , Zhang Limin , Lu Sijin , Huang Wukai , Song Liang , Xu Bin
Published: September 2022

Objective:

To investigate the effect of mesioangular impaction of the mandibular third molars
on distal caries and distal bone loss (DBL) in the adjacent mandibular second molars to provide a
basis for prophylactic impacted third molar extraction.

Methods:

We retrospectively analyzed panoramic radiographs of 736 patients with mesioangularly
impacted mandibular third molars at the Department of Stomatology, Shanghai Fifth People’s Hospital.
The chi-square test, the Kruskal-Wallis test, and logistic regression were performed to analyze the
relationship of patient age, sex, mesial inclination angle, distal caries, and DBL in the mandibular second
molars.

Results:

Patient aged over 30 years and a mesial inclination angle > 30° were risk factors for distal
caries in the mandibular second molars (p < 0.05). Patients aged over 20 years and a mesial inclination
angle of 60°-90° were risk factors for DBL (p < 0.05).

Conclusion:

In patients with mesioangularly impacted mandibular third molars, age and the mesial
inclination angle were positively correlated with the severity of distal caries and DBL in the adjacent
mandibular second molars. These findings could guide dental practitioners to prevent complications of
the adjacent molars during early prophylactic extraction of the mandibular third molars with mesioangular
inclination.
Developing Female Students’ Motor Skills and Improving Basketball Playing Techniques by Means of Special Exercise Machines
Authors: Tymoshenko Oleksii , Domina Zhanna , Malechko Tetiana , Nesterova Tatiana , Korkh-Cherba Oksana , Redkina Maria , Konovalska Liudmyla , Poluliashchenko Tetiana , Soltyk Oleksandr , Shkilna Iryna , Prontenko Kostiantyn , Bloshchynskyi Ihor
Published: September 2022

Introduction:

The article presents the technology of using technical equipment to develop the accuracy of ballistic movements, spatial-dynamic sensitivity during ballthrows and rebounds, as well as speed and strength qualities to improve jumping movements, implementation of fast breakthroughs, strong and long passes in basketball.

Methods:

The research involved 96 female students aged 17-23 years forming the experimental (EG, n = 54) and control (CG, n = 42) groups. The female students of EG played basketball in the conditions of group physical education training sessions using the exercise machines developed by us, and the female students of the CG were engaged in basketball playing according to the traditional program without the use of developed exercise machines and had an initial level of basketball technique. The EG was divided into EG1 (n = 37) and EG2 (n = 17) subgroups, which included female students having initial and high levels of basketball technique mastery, respectively. Female basketball players with an initial level of training (EG1 and СG) had experience of up to 3 years, athletes with a high level of training (EG2) - playing experience of more than 10 years. The technology of technical equipment application in basketball is built on the basis of the use of designed portable exercise machines to implement the tasks of motor and technical training of female basketball players of different levels of training.

Results

The results of the conducted experiment showed that the accuracy of throws from the average distance increased by 40.9% and 29.4% in the EG1 and EG2 female students, and it grew by 9.9% in the CG; from the long distance – by 61.5%, 37.0% and 31.3% respectively; the level of development of speed and strength qualities of female students of all groups improved i. e. the rate of growth in the results of the long jump made 9.7%, 3.2% and 6.5%, respectively; the rate of growth in the results of the high jump made 20.0%, 6.3% and 8.7%, respectively.

Conclusion:

Experimental testing of the technology of using designed exercise machines for the development of motor skills of female basketball students confirmed its effectiveness in terms of improving the spatial and dynamic accuracy of movement, speed and strength, as well as game performance of basketball players at competitions of various levels.
Realization of vocational high school curriculum based on work culture
Authors: Ahyanuardi Ahyanuardi , Rahmadhani Sri , Suryati Lili , Zuryana Zuryana
Published: September 2022

This research aims to find out the implementation of work attitudes based on the business world, the industry, and the world of work in the curriculum used by vocational high schools, where the work culture is a work attitude that prospective workers must own in entering the workforce. The realization of this work culture is seen from several indicators such as the application of work culture needed in schools, the existence of Links and Matches with the needs of the world of work, interpersonal skills owned by students, and intrapersonal abilities possessed by students who are realized in the 5R work culture (Concise, Neat, Resik, Care and Rajin) that apply to the school curriculum. The method used in this research is the Mixed Methode method, combining quantitative research and qualitative research. The study was conducted using instrument questionnaires and structured and open interviews involving respondents from educational institutions and the world of work under the auspices of the Indonesian Electrical and Mechanical Contractors Association. The data analysis technique used is the Milles and Huberman model Likert scale by looking at the percentage generated on the indicator of the competence of the world of work in the good category of 63.73%. But this must remain a thing that needs to be considered and maintained by vocational high schools to produce graduates of good character and a good working culture.
The effect of linguistic intelligence and memory on air traffic control performance of field aviation polytechnic
Authors: Saragih Nisa Azhari , Gustianingsih Gustianingsih , Hanafiah Ridwan
Published: September 2022

Some research has been conducted to understand how general knowledge and short-term memory affect academic achievement. However, research that links these two predictors with air traffic control performance in a laboratory has not been found. Twenty-four ATC cadets participated in this research. This is associative research with multiple correlation analysis that aims to find the correlation between linguistic intelligence and short-term memory toward cadets’ air traffic control performance in Aerodrome Control Tower (TWR) Laboratory. The research instruments used are oral proficiency interview, Intelligence Structure Test (IST), and air traffic control simulation. Data obtained, then, are analyzed by using the product-moment method of correlation. The results show that there is a positive correlation among the three variables with the level of closeness that falls in the high category that can be seen from the correlation coefficient value. In fact, linguistic intelligence and short-term memory both contribute to air traffic control performance during simulations. These findings offer several implications for the training program to promote success in learning air traffic control, especially in the laboratory.
Successive Detection of Telomerase by IHC and Assessment of Telomere Length by Q-FISH in Paucicellular Cumulus Samples from Cumulus-Oocyte Complexes Obtained in Assisted Reproduction Programs
Authors: Pendina Anna , Krapivin Mikhail , Mekina Irina , Aleksandrova Irina , Sagurova Yanina , Komarova Evgeniia , Ishchuk Mariia , Tikhonov Andrei , Bespalova Olesya , Gzgzyan Alexander , Kogan Igor , Efimova Olga
Published: September 2022

This paper suggests an approach for the use of a single paucicellular histological sample to investigate two characteristics indicative of the cell’s functional potential: 1) the content of telomerase reverse transcriptase (TERT) and 2) the telomere length. An algorithm has been suggested for the successive detection of the catalytic telomerase subunit with immunohistochemical staining and assessment of telomere length with Q-FISH on the same set of cells. The described approach uses three incontestable advantages of the FISH technique, namely, the possibility of analyzing target sequences in individual cells and paucicellular samples, the performance of several successive hybridization rounds with different FISH probes on the same sample, and the examination of genomic regions consisting of repeats. This approach has been applied to assess the TERT content and telomere length in cumulus cells from human cumulus-oocyte complexes obtained from assisted reproduction programs. This approach provides an opportunity to examine the correlation between the TERT content and telomere length in cumulus cells surrounding the oocyte and the oocyte's capacity for fertilization, as well as the subsequent pre- and post-implantation development of the resulting embryo.
Evaluating the impact of the website campaign “A ti también te puede tocar” (“It could also be you”) to spread awareness of systemic autoimmune rheumatic diseases (Preprint)
Authors: De las Heras-Alonso Ana , Seoane-Mato. Daniel , Guerra Mercedes , Macía-Villa Cristina
Published: September 2022

BACKGROUND

“A ti también te puede tocar” (“It could also be you”) was an awareness campaign launched to improve the general public’s knowledge of systemic autoimmune rheumatic diseases (SARDs). The present study focusses on visits to the landing page of the campaign website (lasaludnoesunjuego.com) and evaluates the website’s reach and engagement, as well as its effectiveness in facilitating the search for helpful information.

OBJECTIVE

We evaluated the impact of the web-based campaign on awareness of SARDs among the public. The campaign was implemented with the aim of spreading key messages related to these diseases, improving knowledge among patients and the public, and engaging people in the management of their diseases.

METHODS

Process evaluation measurements were based on Google Analytics metrics.

RESULTS

We recorded 107,657 single sessions by 87,059 new users involving 437,285 page views during the observation period (launch of the website in May 2021 to end of campaign in December 2021). The bounce rate for the page was 24.53%, with an average session duration of 5 minutes, 59 seconds and an average of 4.06 pages viewed per session. The results also showed that most users displayed more than 25% of the page and that the video advertisement was played 2,795,749 times.

CONCLUSIONS

This study demonstrates the usefulness of the website campaign “A ti también te puede tocar” in terms of reach and engagement and provides insight into the ways in which websites can be used as part of a multimedia strategy to improve health literacy. However, future campaigns would require metrics on social media content, as well as a survey of website users to understand the level of awareness they have achieved.
Construction and application of a comprehensive index for gastrointestinal diseases monitoring health index in China: a nationwide study (Preprint)
Authors: Cheng Zhiyuan , Gao Ye , Mao Fan , Lin Han , Jiang Yingying , Sun Chang , Xin Lei , Li Zhaoshen , Wan Rong , Zhou Maigeng , Wang Luowei ,   China Gastrointestinal Health Expert Group (CGHEG)
Published: September 2022

BACKGROUND

The level of medical care and medical burden varies greatly among sub-regions in China. A comprehensive monitoring system is urgently needed to detect the Gastrointestinal Diseases (GD) to improve the rationality of resource allocation.

OBJECTIVE

The main objective of this study was to construct the China Gastrointestinal Health Index (GHI) and evaluate the status of prevention and treatment of GD in different provinces.

METHODS

This study collected multi-source data, including national surveillance, surveys, registration systems, and scientific research, and used literature review, Delphi method and Analytic Hierarchy Process (AHP) model to construct GHI system. GHI scores were calculated for each province in China, with scores ranging from 0 to 100.

RESULTS

The GHI system in China includes the Prevalence of Gastrointestinal Non-Neoplastic Diseases (GNND) and Gastrointestinal Neoplasms (GN), the Exposure to Risk Factors, the Prevention and Control of Risk Factors, and the Clinical Treatment of GD. The weight of the four dimensions from high to low was the Prevalence of GNND and GN (0.3246), Clinical Treatment of GD (0.2884), Prevention and Control of Risk Factors (0.2606), Exposure to Risk Factors (0.1264). The overall GHI for China in 2019 was 49.89, varying from 39.19 to 76.13 across all the sub-regions. The total GHI score in the eastern region is generally higher than that in the western region.

CONCLUSIONS

GHI is an effective monitoring system in China. In the future, big data should be used to strengthen and improve the GHI system to ensure its practical effect in the improvement of healthy life expectancy, the prevention of GD, and medical policies in China.
Consumers’ Needs for Laboratory Results Portals: Questionnaire Study (Preprint)
Authors: Monkman Helen , Griffith Janessa , MacDonald Leah , Lesselroth Blake
Published: September 2022

BACKGROUND

Over the last decade, there has been an increase in the number of health care consumers (ie, patients, citizens, and laypeople) with access to their laboratory results through portals. However, many portals are not designed with the consumer in mind, which can limit communication effectiveness and consumer empowerment.

OBJECTIVE

We aimed to study design facilitators and barriers affecting consumer use of a laboratory results portal. We sought to identify modifiable design attributes to inform future interface specifications and improve patient safety.

METHODS

A web-based questionnaire with open- and closed-ended items was distributed to consumers in British Columbia, Canada. Open-ended items with affinity diagramming and closed-ended questions with descriptive statistics were analyzed.

RESULTS

Participants (N=30) preferred reviewing their laboratory results through portals rather than waiting to see their provider. However, respondents were critical of the interface design (ie, interface usability, information completeness, and display clarity). Scores suggest there are display issues impacting communication that require urgent attention.

CONCLUSIONS

There are modifiable usability, content, and display issues associated with laboratory results portals that, if addressed, could arguably improve communication effectiveness, patient empowerment, and health care safety.
Experience of and use of compassion (Codonopsis javanica (Blume) Hook.F & Thoms) of ethnic Minority Communities in Van Ho District, Son La Province
Authors: Ngoc Nguyen Thi Bich
Published: September 2022

This study was conducted with the aim of summarizing and evaluating the experiences of ethnic minority communities in the process of exploiting and using Codonopsis javanica (Blume) Hook.F & Thoms in Van Ho district, Son La province. The research method community interview is applied, the interviewees are those who directly use, exploit, trade and the village heads, healers, mothers, interviewed 80 households in total. The data processing method calculates the percentage based on the answer sheet and notebook. The results show that, 100% of the surveyed households know, can recognize and use C. javanica. This is a fairly popular product locally, but now the quantity is not much. The community clearly describes the growing place, morphology, season, knows how to use the product for health care and trade; 100% harvesting activities are carried out from the wild, breeding activities have not been carried out, only 6.25% of households have tried sowing seeds and only 2.5% of households have tried to plant some C. javanica around the house; 87.5% of mining households are to sell for income; 86.25% of interviewed households want to learn more experience in propagation and planting but only 75% of them are willing to plant if the output market is stable. Experience in commercializing the product is not available, the community only brings the harvested products to the local market or shops to resell. The results from this study show that the local community has a good source of knowledge about C. javanica, but it has not been exploited and applied to conservation and sustainable development of the species. Therefore, this is an issue that needs attention and support, combining both local and technical knowledge, both in terms of the output market so that C. javanica becomes a strength in supporting household economic stability.
Impacto de la pandemia COVID-19 en las mujeres colombianas a la luz del quinto objetivo de desarrollo sostenible de la agenda 2030: 2020-2021
Authors: Cárdenas Poveda Margarita
Published: September 2022

En el 2015, fue adoptada por la Asamblea General de las Naciones Unidas la Agenda 2030 compuesta por 17 objetivos (ODS) y 169 metas como un plan de acción en favor de las personas, el planeta y la prosperidad. El ODS 5 pretende lograr la igualdad de género y empoderar a todas las mujeres y niñas. El 11 de marzo de 2020, la Organización Mundial de la Salud anunció que la nueva enfermedad ocasionada por el virus SARS-CoV-2 que corresponde al COVID-19, puede caracterizarse como una pandemia. Se estima que, a nivel mundial, al menos tres millones de personas fallecieron por el virus en 2020. Esta crisis ha exacerbado las desigualdades ya existentes entre hombres y mujeres en el ámbito laboral, familiar, profesional, de salud, de acceso a tecnología, educación, etcétera, lo cual refleja que la disparidad de género distribuye de forma desproporcional las responsabilidades y retribuye económicamente tan solo algunas de las actividades realizadas por las mujeres y niñas. El presente artículo a través de una metodología evaluativa muestra a partir de un enfoque de género, el nivel de coherencia de algunas de las medidas más importantes expedidas por el gobierno colombiano para conjurar la crisis en relación con el ODS 5. Se concluye que estas resultan ser insuficientes y poco coherentes con el contenido y alcance del ODS 5 y sus metas, aun cuando teóricamente en esta regulación se pretende imprimir la igualdad de género y el empoderamiento de las mujeres y niñas, en la práctica, estas tienen poco desarrollo y materialización.
“Listening to a Great Artist, I Found Something Great and Necessary…”: Simon Fix’s Letters to Maxim Gorky and about Maxim Gorky (Based on the Materials of A.M. Gorky’s Archive)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Zhukhovitskaya Larisa G.
Published: September 2022

This publication of materials from A.M. Gorky’s archive supplements studies related to the name of the artist Simon Fix, new facts and details of his life and work. The only mention of Fix’s name in Gorky's letter to the publisher A. Kogan (the publication of L. Fleishman in 1979) remained without comment for a long time and scattered information about the artist left significant gaps in his biography. V. Khazan's research, supplemented by the publication of Fix’s letters to R. Friedlander and N. Friedlander, kept in the archives of David and Yevsey Shor (National Library of Israel, Jerusalem), recreates the main episodes of the artist's creative biography. Letters stored in the A.M. Gorky’s Archive reveal the details of a previously unknown acquaintance between the artist and the writer. Presented corpus of Fix’s letters — three letters to Gorky and four letters to relatives — testifies to their rather long acquaintance and Gorky’s obvious interest in works and personality of the young painter. The content of Fix’s letter to Gorky dated January 28, 1936 continues the theme of the conversation with Gorky during the meeting in Sorrento, which Fix described to his relatives in April 1928. It is logical to assume that its topics — art education and the position of artists in Soviet society — were discussed with Gorky also in the period between these two dates: perhaps researchers will have a chance to verify it.
“The Fat General” and Prince Gremin: Transformations of the Literary Image
Authors:   Institute of Scientific Information for Social Sciences of the Russian Academy of Sciences, Dushenko Konstantin V.
Published: September 2022

The noble old man, Tatiana’s husband, became part of the “supertext” of “Eugene Onegin” thanks to Tchaikovsky’s opera (1879) and Dostoevsky’s “Pushkin speech” (1880). The “aging” of this image, possibly, was facilitated by the contamination with the image of Prince Vereisky from Pushkin’s novel “Dubrovsky.” In the story “Uncle’s Dream” Dostoevsky refers to both of these images. Prince Gremin first appeared in the story in Bestuzhev-Marlinsky’s story “The Trial” (1830). Thanks to Gogol’s example, the surname Gremin was repeatedly used as a household name in an ironic context, but Tchaikovsky’s Gremin is purely positive lyrical character. In “Pushkin speech,” Tatyana’s husband is not just an old man, but a sufferer “in the taste of Dostoevsky.” A parody reference to this image is contained in Chekhov’s story “The Mysterious Nature” (1883).
Valery Bryusov and his Students. The Case of Nadezhda L’vova
Authors:   Silver Age museum (V.Ya. Briusov House), Vladimir Dahl State Museum for the History of Russian Literature, Orlova Monika V.
Published: September 2022

The article is devoted to the outstanding Russian poet of the late 19th–early 20th century Valery Bryusov as a teacher who influenced many of his contemporaries. The paper starts with his students at “Bryusov Institute” overview. Then the critic Korney Chukovsky’, the writer Alexei Remizov’, and the poet Nikolai Gumilyov’ attitudes to their teacher Bryusov are briefly reviewed. The article mostly focuses on the relationships between Bryusov and his female students including his wife Ioanna Bryusova, and a writer Nina Petrovskaya. The special attention is given to Bryusov’s influence on Nadezhda L’vova. The article contains a review of a recently edited book about Nadezha L’vova by Tat'yana Karpacheva. The appendix document “In dubio pro reo” written by lawyer V.K. Chakilev refutes all the charges against Bryusov who was accused of the suicide of L’vova in the book.
Confucius in “World Literature.” V.M. Alekseev’s Report on the Chinese Philosopher in 1921 (Based on the Materials of A.M. Gorky Archive of IWL RAS)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Chechnev Yakov D.
Published: September 2022

The article introduces an unknown report of the sinologist V.M. Alekseev on the alleged translation of Confucius, made at the editorial Board of the publishing house “World Literature,” into scientific circulation. The speech preserved in the typewritten record of the meeting of April 1, 1921, represents a prominent event both in the history of the publishing house itself and in the history of Russian Sinology. The presented material shows that the “World Literature” was not only a publishing institution of the first years of Soviet power, but also a major scientific center, where it was possible to gather leading writers and scientists. The attached report by V.M. Alekseev is supplemented by an extended discussion, which clearly illustrates the scientific level of the debates that were conducted in the “World Literature” during the preparation of the majority of both published and conceived books. At the same time, the published report is valuable as an independent research covering the history of the study of Confucius, existing translations, as well as the domestic reception of Chinese philosopher’s teachings.
On the Work of Vladimir Mayakovsky with Poster Texts (According to his Notebooks)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Mikhalenko Natalia V.
Published: September 2022

The article deals with Mayakovsky's notebook no. 8 (January –May 1921), provided by the State Museum of Vladimir Mayakovsky. It demonstrates his work on the inscriptions for twelve Glavpolitprosvet Posters: “Look!,” “Hey you, the Urals mining worker! Without the help from your mine, it is impossible to put an end to the havoc in the economy!”, “Let’s get to work, comrades!”, “On my May-Day meeting…”, etc. Some of these posters, covering the important social and economic topics, have not survived to today, so the notebook becomes an important source of information about the principles of Mayakovsky’s propaganda work. A small fragment of the second version of Mayakovsky’s play “Mystery-Bouffe” can also be found in it, along with a receipt for the rent of a summer cottage in Akulova Gora that sheds some light on the details of the poet’s life. A holistic historical, literary and textual examination of the notebook helped to reveal the dates of creation of particular notes, and these, in turn, were related to the context of time and other contemporary works of the poet. The article examines the characteristic features of edits made by Mayakovsky and the order of their introduction. Also the author compares the draft texts of the posters “Hey, you, the Urals mining worker! Without the help from your mine, it is impossible to put an end to the havoc in economy!” and “Hey, mining worker!” to the final copies. The results of the research shows the characteristic features of the poet's creative vision of the actual topics of his time. The texts of the notebook are published for the first time.
Las olas progresistas en América Latina (1989-2015 y 2015-2022) y la respuesta conservadora en la región.
Authors: Navarro Adriana Apolinar , Moreno Velador Octavio Humberto , Sánchez Espinoza Francisco
Published: September 2022

Contrariamente a las visiones que sostienen tanto un final de ciclo progresista como la existencia de un bloque autoritario-populista de izquierda en América Latina, sostenemos que lo que se ha observado en los últimos veinte años es la persistencia de movimientos sociopolíticos vinculados a partidos y gobiernos progresistas de carácter posneoliberal, los cales han mantenido un notable éxito electoral en el mediano plazo. Así mismo, el progresismo ha experimentado dos grandes oleadas a nivel regional mediadas por una contraoleada de fuerzas de centro derecha y extrema derecha en la región, y si bien ha sufrido reveses, han sido los menos derivados de procesos electorales y los más importantes se pueden atribuir a golpes institucionales o acciones de guerra legal (lawfare).
espetáculo contemporâneo de american idol
Authors: Souza Pablo Cezar Laignier de
Published: September 2022

O objetivo deste trabalho é refletir a respeito das possibilidades de contribuição da teoria sobre a sociedade do espetáculo para a análise dos reality shows de música, posto que o livro de Guy Debord apresenta características gerais da sociedade contemporânea que podem ser encontradas em alguns produtos de entretenimento atuais, como os reality shows musicais. Tendo como aporte teórico o livro de Debord e artigos acadêmicos sobre reality shows, este trabalho apresenta um estudo de caso do programa American Idol. O artigo é dividido em três seções: a primeira aborda o conceito de Espetáculo na obra de Debord; a segunda discute os reality shows e suas características primordiais; a terceira apresenta uma análise sobre alguns aspectos do programa American Idol, buscando evidenciar as relações entre reality shows e Espetáculo.
Websérie documental
Authors: Souza José Jullian
Published: September 2022

A pesquisa objetiva revisitar o conceito de websérie documental a partir da sua definição e características, que a definem como uma nova forma de se pensar a produção jornalística audiovisual nativa em ambientes digitais. Deste modo, a pesquisa parte da seguinte problemática: quais são as características que contemplam a definição de websérie documental? Como objetivo geral, a pesquisa visa apresentar características do objeto de estudo e uma proposta aproximação para uma possível definição. Já os objetivos específicos, são: a) identificar as lacunas acerca do conceito de websérie documental e b) situar a produção como uma proposta de modelo de negócio no cenário de produção jornalística audiovisual digital em consonância com a convergência midiática. O percurso metodológico perpassa por uma abordagem qualitativa, uso da pesquisa exploratória e descritiva sobre as webséries, visando um aprofundamento sobre o seu conceito e características. Identifica-se que o conceito de websérie documental mantém diálogo não somente com a produção jornalística audiovisual convergente e nativa da internet, mas, sobretudo, possibilita visualizar as transformações no fazer jornalístico através de suas características, ainda que se mantenha uma proximidade com o audiovisual das mídias tradicionais. Assim, entende-se que há uma (re)modelação do jornalismo audiovisual no ambiente digital. Além disso, mesmo propondo uma definição, o conceito de websérie ainda está em construção e desenvolvimento, pois o mesmo é visualizado por diferentes pesquisadores que apresentam diversas características acerca do objeto audiovisual.
Integrated reporting practices and firm performance: A review study
Authors: Alatawi Mohammed Saleem , Daud Zaidi Bin Mat
Published: September 2022

The purpose of this article is to provide a taxonomy of existing literature on the relationship between integrated reporting and business performance. Published research articles related to integrated reporting practices were collected from various reputed journals published by Springer, Taylor & Francis, JSTOR, Wiley, Elsevier, Sage, and Emerald. A total of 110 research articles were examined. After reviewing all the articles rigorously, we found that the study related to the assessment of integrated reporting practices was mostly concentrated in developed countries as compared to developing countries. The result differs in various cultural and economic contexts and there is no universally accepted direction of the relationship between integrated reporting and firm performance. We further found that there is some decline in research studies in recent years. This study contributes to the academic literature by providing a comprehensive analysis of the various types of studies that were undertaken so far in the area of Integrated reporting and firm performance.
The dynamics of insurance sector development and economic growth
Authors: Baruti Blerta Haliti
Published: September 2022

Through this paper, we were able to analyze the insurance system in Kosovo by looking at its structure, the degree of concentration of insurance companies in the insurance industry, and the types of products they offer. The analysis was based on statistical and qualitative data through the studies and analysis of insurance industry development in other countries. Furthermore, secondary data from the Central Bank of Kosovo, insurance companies, and the Insurance Association of Kosovo was used for the empirical analysis. Moreover, in order to obtain more data, one survey was conducted. The survey includes a more general audience, specifically employed people. The main research question of this study was whether insurance development has some effect on the financial markets in developing countries. The analysis conducted found that the insurance industry is important for the development of the financial markets in developing countries and also was mentation in research by Cristea, Marcu, and Cârstina (2014). Additionally, the analysis for the case of Kosovo shows that macroeconomic and financial sector-related factors are important drivers for the future development of the insurance industry in Kosovo. Therefore, macroeconomic, institutional, and regulatory environments are crucial for supporting the future growth of the insurance industry in Kosovo.
A relaxation oscillator
Authors: Wei Yuchen
Published: September 2022

a relaxation oscillator is designed.
Safety, tolerability, bioavailability, and biological activity of inhaled interferon-α2b in healthy adults: The IN2COVID phase 1 randomized trial
Authors: Garcia-Huidobro Diego , Iturriaga Carolina , Perez-Mateluna Guillermo , Fajuri Paula , Severino Nicolas , Urzua Marcela , Fraga Juan Pablo , Cruz Javiera de la , Poli Cecilia , Castro-Rodriguez Jose , Fish Eleanor , Borzutzky Arturo
Published: September 2022

Aim: Interferons (IFNs) have been identified as a potential treatment
alternative for Coronavirus Disease 19 (COVID-19). This study assessed
the safety, tolerability, bioavailability, and biological activity of
inhaled interferon-α2b (IFN-α2b) in healthy adults. Methods: A
double-blind, randomized, phase 1 clinical trial was conducted with two
cohorts of healthy subjects aged 18-50 years old. The first cohort
received 2.5 MIU of inhaled IFN-α2b twice daily for 10 days (n=6) or
placebo (n=3); the second cohort received 5.0 MIU of inhaled IFN-α2b in
a similar scheme (n=6) or placebo (n=3). The first two doses were
administered in an Emergency Department, then participants completed
their treatment at home. Safety was measured through vital signs, new
symptoms, and laboratory tests. Tolerability was measured as the
participant´s treatment acceptability. Bioavailability and biological
activity were measured from serum IFNα levels and real-time quantitative
PCR of interferon-induced genes in blood before and after treatments.
Results: Exposure to inhaled IFN-α2b at 2.5 MIU or 5 MIU doses did not
produce significant changes in participant vital signs, or elicit new
symptoms, and standard hematological and biochemical blood measurements
were comparable to those recorded in individuals who received placebo.
All adverse events were mild or moderate and did not require medical
care. Participants reported very high tolerability. A dose-dependent
mild increase in serum IFN-α concentrations and an increase in serum RNA
expression of IFN-induced genes were observed after treatment.
Conclusion: Inhaled IFN-α2b was safe, well-tolerated, and induced
systemic biological activity in healthy subjects.
PERSISTENT LEFT SUPERIOR VENA CAVA WITHOUT RIGHT SVC DURING FETAL LIFE
Authors: Sayıcı İlker , Ari Mehmet
Published: September 2022

Persistent left superior vena cava (SVC) without the right SVC is very
rare and occurs in 0.07%–0.13% of patients with congenital heart
defects. An enlarged coronary sinus detected during cardiac examination
in the prenatal period is the first finding that raises suspicion for
this anomaly. In this report, a patient was presented who was referred
with the prediagnosis of cor triatriatum sinister in the antenatal
period and diagnosed with isolated persistent left SVC.