bluuebunny/crossref_metadata_2025 huggingface dataset:
Magnetron Sputtered Lead Titanates Thin Films for Pyroelectric Applications: Part 1: Epitaxial Growth, Material Characterization
Authors: Fathipour Morteza , Xu Yanan , Rana Mukti
Published: December 2023

Pyroelectric materials, are those materials with the property that in the absence of any externally applied electric field, develop a built-in spontaneous polarization in their unit cell structure. They are regarded as ideal detector elements for infrared applications because they can provide fast response time and uniform sensitivity at room temperature over all wavelengths. Crystals of the perovskite Lead Titanate (PbTiO3) family show pyroelectric characteristics and undergo structural phase transitions. They have a high Curie temperature (the temperature at which the material changes from the ferroelectric (polar) to the paraelectric (nonpolar) phase), high pyroelectric coefficient, high spontaneous polarization, low dielectric constant, and constitute important component materials not only useful for infrared detection, but also with vast applications in electronic, optic, and Micro-electromechanical systems (MEMS) devices. However, the preparation of large perfect, and pure single crystals of PbTiO3 is challenging. Additionally, difficulties arise in the application of such bulk crystals in terms of connection to processing circuits, large size, and high voltages required for their operation. A number of thin film fabrication techniques have been proposed to overcome these inadequacies, among which, magnetron sputtering has demonstrated many potentials. By addressing these aspects, the review article aims to contribute to the understanding of the challenges in the field of pyroelectric materials, highlight potential solutions, and showcase the advancements and potentials of pyroelectric perovskite series including PbZrTiO3 (PZT), PbxCa1−x (PZN-PT), etc. for which PbTiO3 is the end member. The review is presented in two parts. Part 1 focuses on material aspects, including preparation methods using magnetron sputtering and material characterization. We take a tutorial approach to discuss the progress made in epitaxial growth of lead titanate-based ceramics prepared by magnetron sputtering and examine how processing conditions may affect the crystalline quality of the growing film by linking to the properties of the substrate/buffer layer, growth substrate temperature, and the oxygen partial pressure in the gas mixture. Careful control and optimization of these parameters are crucial for achieving high-quality thin films with desired structural and morphological characteristics.
Exploring Inhibition Mechanism of Si on Cementite Nucleation in Hypereutectoid Steel: Experiments and First-Principles Calculations
Authors: Xu Taixu , He Zhijun , Han Xiao , Yang Xin , Hou Xinmei
Published: December 2023

To clarify the influence of Si on cementite nucleation during the solidification of hypereutectoid steel, the types and microstructure of cementite in hypereutectoid steel with various Si concentrations were investigated by X-ray diffraction and scanning electron microscopy. Additionally, the interfacial properties of γ-Fe/Fe3C were studied using the first-principles density functional theory, including work on adhesion, interfacial energy, and electronic structure, with the aim of elucidating the impact mechanism of Si on the cementite nucleation. The results showed that increasing Si concentrations (0–0.42 wt.%) had a negligible effect on the types of cementite in as-cast hypereutectoid steel. However, the average number of cementite lamellae per unit area decreased significantly, indicating that an increase in Si concentrations has an inhibitory effect on cementite nucleation. This can be attributed to the effect of Si on the interfacial properties of γ-Fe (010)/Fe3C (010), where the presence of Si disrupts the charge distribution of the γ-Fe (010)/Fe3C (010) interface and decreases the hybridization of atom orbits on each side of the interface, resulting in a decrease in the interatomic interaction force. This is reflected in the decrease in the work of adhesion (from 6.92 J·m−2 to 6.78 J·m−2) and the increase in the interfacial energy (from −1.42 J·m−2 to −1.31 J·m−2). As a result, the stability of the γ-Fe (010)/Fe3C (010) interface is reduced, making it difficult for the composite structure to form. This indicates that Si doping inhibits cementite nucleation on austenite.
Investigating the Influence of PbS Quantum Dot-Decorated TiO2 Photoanode Thickness on Photoelectrochemical Hydrogen Production Performance
Authors: Kim Yeonjae , Seo Joo-Won , Lee In-Hee , Kim Jae-Yup
Published: December 2023

To maximize the photoelectrochemical (PEC) hydrogen production performance of quantum dot (QD)-decorated photoelectrodes, it is crucial to prioritize the optimization of electrode’s structure, including thickness and porosity. In this study, we prepare PbS QD-decorated mesoporous TiO2 photoanodes for PEC hydrogen production, and systematically investigate the influence of the photoanode thickness on optical properties and PEC performances. As the thickness of photoanodes increases from 6.4 µm to 16.3 µm, the light absorption capability is enhanced across the entire visible and near-infrared (IR) spectrum due to the improved loading of PbS QDs. However, the photocurrent density is optimized for the 11.9 µm thick photoanode (15.19 mA/cm2), compared to the 6.4 µm thick (10.80 mA/cm2) and 16.3 µm thick photoanodes (11.93 mA/cm2). This optimization is attributed to the trade-off between the light absorption capability and the efficient mass transfer of the electrolyte as the photoanode thickness increases, which is confirmed by the lowest charge transfer resistance (Rct) evaluated from the electrochemical impedance data.
Possible Options for Utilization of EU Biomass Waste: Pyrolysis Char, Calorific Value and Ash Content
Authors: Iwanek (nee Wilczkowska) Ewa M. , Nietrzeba Urszula , Pietras Marta , Marciniak Aleksandra , Głuski Gustaw , Hupka Jakub , Szymajda Miłosz , Kamiński Jakub , Szerewicz Cezary , Goździk Aleksandra , Kirk Donald W.
Published: December 2023

The application of biomass as a co-feed in coal power plants and in standalone biomass power plants, as well as in char production for soil remediation, is a currently important issue. This paper reports on the investigation of biochar formation from agricultural waste crops that are used for soil upgrading, but which do not meet the standards of EU crops, as well as largescale food processing waste. These were compared to test results from basket willow, which is commonly used for energy generation. Food industry waste is often produced in cities on a large scale and is generally easier to process due to lack of other stream components. The key parameters, namely, the content of volatiles, energy content of the formed biochar and the composition of the ash, were determined for a number of herbaceous materials locally available in the European Union. All of them can be used as a cheap source of biochar. A novel procedure of capturing volatiles and hence minimizing the PAH content in the biochar, as well as enabling the recovery of energy from the volatiles is presented. Knowledge of the composition and form of elements in ash is very important for designing ash management systems if co-combustion is implemented. The aim of this study was to determine if the types of biomass are better suited for biochar production or energy generation.
Synthesis of CdSe Quantum Dots in Two Solvents of Different Boiling Points for Polymer Optical Fiber Technology
Authors: Kiczor Anna , Mergo Paweł
Published: December 2023

Polymer materials find many applications in various industries. Efforts are being made to obtain structures with increasingly better properties. It is necessary not only to obtain new materials but also to modify existing structures. Such is the situation with polymer optical fibers. The widespread use of polymer optical fibers is impossible, due to their very high optical losses compared to glass optical fibers. The solution to this problem can be the manufacturing of polymer active optical fibers. Active fibers are the basic components of fiber optic amplifiers and lasers that allow the direct amplification of light inside the fiber. In order for their operation to be the most effective, it is necessary to use dopants. The most commonly used are lanthanide ions isolated from the polymer network, active organic dyes, and quantum dots. These dopants are characterized by very high luminescence and long glow times. Quantum dots of CdSe are made using two organic solvents that differ in boiling points—hexane (a low-boiling solvent with a boiling point of 69 °C) and 1-octadecene (a high-boiling solvent with a boiling point of 315 °C). This work aims to test whether the type of solvent used to obtain quantum dots affects the doping capabilities of polymer structures, from which optical fibers can then be drawn.
Numerical Simulation and Experimental Analysis on Seam Feature Size and Deformation for T-Joint Laser–GMAW Hybrid Welding
Authors: Wei Nai-Kun , Shi Jin , Yang Run-Dang , Xi Jun-Tong , Luo Xiao-Meng , Yin Xu-Yue , Zhang Rui-Xue
Published: December 2023

As an innovative technique, laser–GMAW hybrid welding manifests significant superiority in enhancing welding productivity and quality, albeit the optimization of process parameters poses a challenge for practical application. The present manuscript elucidates the influence of process parameters on the dimensional characteristics of the welding seam and the distortion of 8 mm T-joints in the context of laser–GMAW hybrid welding, and channels both simulation and experimentation. The outcomes denote that the dual conical model serves as an efficacious aid for the numerical simulation of T-joint laser–GMAW hybrid welding. Furthermore, the repercussions of process parameters on welding seam dimensional characteristics remain consistently similar in both the simulation and experimental results. From the simulation outcomes, it becomes apparent that the distortion of the base material can be efficiently managed by implementing anti-distortion measures. This inquiry offers both a theoretical and experimental foundation for optimizing process parameters of T-joint laser–GMAW hybrid welding, presenting certain engineering applicability.
Rapid Solidification of Invar Alloy
Authors: He Hanxin , Yao Zhirui , Li Xuyang , Xu Junfeng
Published: December 2023

The Invar alloy has excellent properties, such as a low coefficient of thermal expansion, but there are few reports about the rapid solidification of this alloy. In this study, Invar alloy solidification at different undercooling (ΔT) was investigated via glass melt-flux techniques. The sample with the highest undercooling of ΔT = 231 K (recalescence height 140 K) was obtained. The thermal history curve, microstructure, hardness, grain number, and sample density of the alloy were analyzed. The results show that with the increase in solidification undercooling, the XRD peak of the sample shifted to the left, indicating that the lattice constant increased and the solid solubility increased. As the solidification of undercooling increases, the microstructure changes from large dendrites to small columnar grains and then to fine equiaxed grains. At the same time, the number of grains also increases with the increase in the undercooling. The hardness of the sample increases with increasing undercooling. If ΔT ≥ 181 K (128 K), the grain number and the hardness do not increase with undercooling.
Impact Responses and Wave Dissipation Investigation of a Composite Sandwich Shell Reinforced by Multilayer Negative Poisson’s Ratio Viscoelastic Polymer Material Honeycomb
Authors: Zhou Xiaoqiang , Fu Wanbiao , Wang Yun , Yan Hai , Huang Yicang
Published: December 2023

This analysis investigated the impact wave response and propagation on a composite sandwich shell when subjected to a low-velocity external shock, considering hygrothermal effects. The sandwich shell was crafted using face layers composed of functional gradient metal–ceramic matrix material and a core layer reinforced with negative Poisson’s honeycomb. The honeycomb layer consisted of a combination of viscoelastic polymer material and elastic material. The equivalent parameters for the functional gradient material in the face layers were determined using the Mori–Tanaka and Voigt models, and the parameters for the negative Poisson’s ratio honeycomb reinforcement core layer were obtained through Gibson’s unit cell model. Parameters relevant to a low-velocity impact were derived using a modified Hertz contact law. The internal deformations, strains, and stress of the composite sandwich shell were described based on the higher-order shear deformation theory. The dynamic equilibrium equations were established using Hamilton’s principle, and the Galerkin method along with the Newmark direct integration scheme was employed to calculate the shell’s response to impact. The validity of the analysis was confirmed through a comparison with published literature. This investigation showed that a multilayer negative Poisson’s ratio viscoelastic polymer material honeycomb-cored structure can dissipate impact wave energy swiftly and suppress shock effectively.
Properties of High-Entropy Fe30Co20Ni20Mn20Al10 Alloy Produced by High-Energy Ball Milling
Authors: Ammar Chérif Ben , Khitouni Nawel , Mbarek Wael Ben , Alsulami Abdulelah H. , Suñol Joan-Josep , Khitouni Mohamed , Chemingui Mahmoud
Published: December 2023

A high-entropy Fe30Co20Ni20Mn20Al10 (at%) alloy with a face-centered cubic (FCC) crystalline phase was produced through mechanical alloying. This study examined the development of its phases, microstructure, morphology, and magnetic characteristics. Scanning electron microscopy (SEM) was applied to assess the sample morphology in relation to milling times. The changes that the material underwent during milling were investigated using X-ray diffraction. The milling time affected the phase transformation. A single FCC solid solution (crystallite size = 12 nm) was found after 50 h of milling. Additionally, the magnetic characteristics were examined and shown to be associated with microstructural changes. The powder mixture exhibited behavior consistent with soft magnetics, with an Hc value of 8 Am−1 and an Ms value of 165 emu/g. The excellent soft magnetic characteristic may be related to the stability of the FCC phase, which was generated following a 30 h milling process. In addition, the low value of Ms may have originated from the presence of Al atoms in the solid solution and the development of large densities of interfaces and crystal defects.
On the Durability of Icephobic Coatings: A Review
Authors: Nistal Andrés , Sierra-Martín Benjamín , Fernández-Barbero Antonio
Published: December 2023

Ice formation and accumulation on surfaces has a negative impact in many different sectors and can even represent a potential danger. In this review, the latest advances and trends in icephobic coatings focusing on the importance of their durability are discussed, in an attempt to pave the roadmap from the lab to engineering applications. An icephobic material is expected to lower the ice adhesion strength, delay freezing time or temperature, promote the bouncing of a supercooled drop at subzero temperatures and/or reduce the ice accretion rate. To better understand what is more important for specific icing conditions, the different types of ice that can be formed in nature are summarized. Similarly, the alternative methods to evaluate the durability are reviewed, as this is key to properly selecting the method and parameters to ensure the coating is durable enough for a given application. Finally, the different types of icephobic surfaces available to date are considered, highlighting the strategies to enhance their durability, as this is the factor limiting the commercial applicability of icephobic coatings.
Novel Design of Variable Stiffness Pneumatic Flexible Shaft Coupling: Determining the Mathematical-Physical Model and Potential Benefits
Authors: Kaššay Peter , Grega Robert , Urbanský Matej , Krajňák Jozef , Kačír Matúš , Žuľová Lucia
Published: December 2023

Presently, mechanical system vibroisolation is becoming increasingly important. One of the new approaches is semi-active vibroisolation using elements capable of changing a selected mechanical property. These include, among others, pneumatic flexible shaft couplings capable of changing torsional stiffness during operation. The main goal of the article is to examine the potential advantages of a newly patented pneumatic coupling over a current type with the same pneumatic element arrangement. For comparison, parameters determinable from static load characteristics were selected. These parameters are maximum twist angle and torque, average torsional stiffness, and the percentage of torque transmitted by the bellows rubber shell. In all cases, the new coupling had better properties. Since the prototype of the new coupling has not yet been produced, its parameters were determined from its mathematical-physical model. The article contains a full procedure to obtain the static load characteristic of a new coupling type, beginning with the determination of air bellows force/height and volume/height characteristics, then optimum sizes of coupling with regards to the operating range of elements, the dependency of element height on the coupling’s twist angle, and finally the computation of the static load characteristic considering isothermal gas compression. The presented procedure can be applied to any pneumatic bellows where the force/height characteristics of different pressures are given.
Optimal Control of SLBRS with Recovery Rates
Authors: Zhao Xiangqing , Hou Wanmei
Published: December 2023

In the information age, frequent information exchange has provided a breeding ground for the spread of computer viruses. The significant losses caused by computer virus attacks have long rung the alarm for information security. From academia to businesses, and even to government, everyone remains highly vigilant about information security. Researchers have put forward various approaches to combat computer viruses, involving innovative efforts in both the hardware and software aspects, as well as theoretical innovation and practical exploration. This article is dedicated to theoretical exploration, specifically investigating the stability of a computer virus model, known as SLBRS, from the perspective of optimal control. Firstly, a control system is introduced with the aim of minimizing the costs related to network detoxification and diminishing the percentage of computers impacted by the virus. Secondly, we employ the Pontryagin maximum principle to analyze the optimality of a control strategy for the proposed system. Thirdly, we validate the effectiveness of our theoretical analysis through numerical simulation. In conclusion, both theoretical analysis and numerical simulation reveal that the utilization of optimal control analysis to stabilize the SLBRS has been demonstrated to be advantageous in restoring contaminated computer network environments.
Modeling of Rapidly Changing Macroeconomic Processes Based on the Analysis of Jump and Generalized Functions
Authors: Aliukov Sergei
Published: December 2023

In recent years, the economies of many countries around the world have been in a situation of intense, rapidly changing, abrupt processes. The current situation urgently requires a change in the economic paradigm in the near future, which leads to the need to develop new conceptual models. The purpose of the article is to develop basic theoretical principles and practical approaches to modeling macroeconomic processes based on the analysis of jump and generalized functions. The objectives of the study are the following: (1) describe the main types of impulse and jump functions using examples from economic theory and practice; (2) perform an analytical representation of impulse and jump functions; (3) select macroeconomic characteristics to analyze rapidly changing processes in the economy; and (4) create models and mechanisms for forecasting impulsive and abrupt changes in the macroeconomy. The approaches to the development of macroeconomic theory and its methods proposed in the article are not associated with the use of evolutionary continuous functions; for example, power functions, which is typical for many canonical macroeconomic models. These approaches do not include management decisions to achieve optimal values of given target functions, which is typical for recursive macroeconomic models of dynamic programming. This article is about formulating the main provisions of macroeconomic theory and its methods, which, with varying degrees of accuracy, could give a forecast about the upcoming possibility of sudden changes (impulse, shock, spasmodic, and others) in the macroeconomic situation. The research methodology is statistical analysis, special methods developed by the author for studying impulse, and jump processes. As a result of this study, the basic principles of modeling macroeconomic theory based on rapid impulse and abrupt changes were formulated, approaches to constructing the tools of this theory were outlined, and problems and tasks for further research were identified.
LIDAR Point Cloud Augmentation for Dusty Weather Based on a Physical Simulation
Authors: Lian Haojie , Sun Pengfei , Meng Zhuxuan , Li Shengze , Wang Peng , Qu Yilin
Published: December 2023

LIDAR is central to the perception systems of autonomous vehicles, but its performance is sensitive to adverse weather. An object detector trained by deep learning with the LIDAR point clouds in clear weather is not able to achieve satisfactory accuracy in adverse weather. Considering the fact that collecting LIDAR data in adverse weather like dusty storms is a formidable task, we propose a novel data augmentation framework based on physical simulation. Our model takes into account finite laser pulse width and beam divergence. The discrete dusty particles are distributed randomly in the surrounding of LIDAR sensors. The attenuation effects of scatters are represented implicitly with extinction coefficients. The coincidentally returned echoes from multiple particles are evaluated by explicitly superimposing their power reflected from each particle. Based on the above model, the position and intensity of real point clouds collected from dusty weather can be modified. Numerical experiments are provided to demonstrate the effectiveness of the method.
Prospective Antiviral Effect of Ulva lactuca Aqueous Extract against COVID-19 Infection
Authors: Binsuwaidan Reem , El-Masry Thanaa A. , El-Sheekh Mostafa , Seadawy Mohamed G. , Makhlof Mofida E. M. , Aboukhatwa Shaimaa M. , El-Shitany Nagla A. , Elmorshedy Kadreya E. , El-Nagar Maysa M. F. , El-Bouseary Maisra M.
Published: December 2023

Marine algal extracts exhibit a potent inhibitory effect against several enveloped and non-enveloped viruses. The infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has several adverse effects, including an increased mortality rate. The anti-COVID-19 agents are still limited; this issue requires exploring novel, effective anti-SARS-CoV-2 therapeutic approaches. This study investigated the antiviral activity of an aqueous extract of Ulva lactuca, which was collected from the Gulf of Suez, Egypt. The aqueous extract of Ulva lactuca was characterized by high-performance liquid chromatography (HPLC), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and Energy Dispersive X-ray (EDX) analyses. According to the HPLC analysis, the extract comprises several sugars, mostly rhamnose (32.88%). The FTIR spectra showed numerous bands related to the functional groups. EDX analysis confirmed the presence of different elements, such as oxygen (O), carbon (C), sulfur (S), magnesium (Mg), potassium (K), calcium (Ca), and sodium (Na), with different concentrations. The aqueous extract of U. lactuca (0.0312 mg/mL) exhibited potent anti-SARS-CoV-2 activity via virucidal activity, inhibition of viral replication, and interference with viral adsorption (% inhibitions of 64%, 33.3%, and 31.1%, respectively). Consequently, ulvan could be a promising compound for preclinical study in the drug development process to combat SARS-CoV-2.
Alexandrium spp.: From Toxicity to Potential Biotechnological Benefits
Authors: Montuori Eleonora , De Luca Daniele , Penna Antonella , Stalberga Darta , Lauritano Chiara
Published: December 2023

Many dinoflagellates of the genus Alexandrium are well known for being responsible for harmful algal blooms (HABs), producing potent toxins that cause damages to other marine organisms, aquaculture, fishery, tourism, as well as induce human intoxications and even death after consumption of contaminated shellfish or fish. In this review, we summarize potential bioprospecting associated to the genus Alexandrium, including which Alexandrium spp. produce metabolites with anticancer, antimicrobial, antiviral, as well as anti-Alzheimer applications. When available, we report their mechanisms of action and targets. We also discuss recent progress on the identification of secondary metabolites with biological properties favorable to human health and aquaculture. Altogether, this information highlights the importance of studying which culturing conditions induce the activation of enzymatic pathways responsible for the synthesis of bioactive metabolites. It also suggests considering and comparing clones collected in different locations for toxin monitoring and marine bioprospecting. This review can be of interest not only for the scientific community, but also for the entire population and industries.
Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle–Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study
Authors: Kobayashi Yusuke , Fujikawa Tetsuya , Haruna Aiko , Kawano Rina , Ozawa Moe , Haze Tatsuya , Komiya Shiro , Suzuki Shota , Ohki Yuki , Fujiwara Akira , Saka Sanae , Hirawa Nobuhito , Toya Yoshiyuki , Tamura Kouichi
Published: December 2023

Background and Objectives: Omega-3 fatty acids have potent lipid-lowering and antiplatelet effects; however, randomized controlled trials have yet to examine the effect of high-dose omega-3 fatty acid administration on peripheral artery disease (PAD) in hemodialysis patients with dyslipidemia. Therefore, this study aimed to evaluate the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the ankle–brachial index (ABI) and remnant-like lipoprotein cholesterol (RLP-C) levels, which are indicators of PAD severity. Materials and Methods: Thirty-eight participants (mean age: 73.6 ± 12.7 years) were randomly assigned using stratified block randomization to either conventional therapy alone or conventional therapy supplemented with high-dose EPA/DHA (EPA: 1860 mg; DHA: 1500 mg) for a three-month intervention period. Patients in the conventional therapy alone group who opted to continue were provided with a low-dose EPA/DHA regimen (EPA: 930 mg; DHA: 750 mg) for an additional three months. The baseline and 3-month values for RLP-C, an atherogenic lipid parameter, and the ABI were recorded. Results: The results of the 3-month assessments revealed that the mean RLP-C changes were −3.25 ± 3.15 mg/dL and 0.44 ± 2.53 mg/dL in the EPA/DHA and control groups, respectively (p < 0.001), whereas the changes in the mean ABI values were 0.07 ± 0.11 and −0.02 ± 0.09 in the EPA/DHA and control groups, respectively (p = 0.007). In the EPA/DHA group, a significant negative correlation was found between the changes in RLP-C levels and the ABI (r = −0.475, p = 0.04). Additionally, the change in the RLP-C levels independently influenced the change in the ABI in the EPA/DHA group, even after adjusting for age, sex, and statin use (p = 0.042). Conclusions: Add-on EPA/DHA treatment improved the effectiveness of conventional therapy (such as statin treatment) for improving the ABI in hemodialysis patients with dyslipidemia by lowering RLP-C levels. Therefore, clinicians involved in dialysis should focus on RLP-C when considering residual cardiovascular disease risk in hemodialysis patients and should consider screening patients with elevated levels.
Left-Side Contrast-Injection-Induced Pseudopathologic Vertebral Enhancement in Oncology Patients without Venous Obstruction: A Report of Two Cases
Authors: Bae Kyungsoo , Moon Jin Il , Jeon Kyung Nyeo
Published: December 2023

The appearance of sclerotic bone lesions in contrast-enhanced computed tomography (CT) scans is often a significant concern for the possible presence of metastatic disease, especially in individuals with a known history of cancer. Prior research has demonstrated that in cases where patients suffer from thrombosis in major veins like the superior vena cava or the brachiocephalic vein, vertebral venous congestion can create imaging patterns on CT scans that resemble sclerotic bone metastases. However, instances of such imaging findings in patients without any form of venous obstruction are not commonly reported. In this study, we present cases of pseudopathologic vertebral enhancement observed consistently following left-side contrast injections in cancer patients devoid of venous obstruction. We aim to discuss and propose a potential mechanism for this phenomenon, drawing attention to a less commonly recognized diagnostic consideration in oncological imaging.
Fractional CO2 Laser, Radiofrequency and Topical Estrogen for Treating Genitourinary Syndrome of Menopause: A Pilot Study Evaluating the Vulvar Vestibule
Authors: Campos Madalena Leonor Pereira , Bianchi-Ferraro Ana Maria Homem Mello , de Oliveira Carla Dias , Nogueira Maria Cristina Caceres , Sartori Marair Gracio Ferreira , Fusco Irene , Lugollo Angela Flavia , De Góis Speck Neila Maria
Published: December 2023

Background and Objectives: Genitourinary syndrome of menopause (GSM) affects more than half of postmenopausal women. This study aimed to evaluate the clinical and histological aspects of microablative fractionated CO2 laser (CO2L), microablative fractionated radiofrequency (RF) and intravaginal estrogen (ET) therapy as GSM treatments for the vulvar vestibule. Materials and Methods: This study included postmenopausal women with at least one moderate-to-severe complaint of GSM. Women in the CO2L and RF groups received three monthly sessions of outpatient vulvovaginal therapy. The procedures were performed 30 min after applying 4% lidocaine gel to the vulva and vaginal introitus. Vulvar vestibular pain was assessed after each application using a 10-point VAS. A follow-up evaluation was performed 120 days after beginning each treatment. Digital images of the vulva were obtained and a 5-point Likert scale (1 = much worse, 2 = worse, 3 = neutral, 4 = better, 5 = much better) was used to assess the global post-treatment women’s impression of improvement regarding GSM. Results: A significant change in clinical aspects of the vulva was observed after all treatments with a reduction in the atrophic global vulvar aspect and an enhancement of the trophic aspect. High satisfaction was also reported after treatment according to the Likert scale evaluation: CO2L (4.55 ± 0.97), RF (4.54 ± 0.95), CT (4 ± 1.41), p = 0.066. Histological evaluation revealed enhanced dermal papillae before pre-treatment, significantly reducing post-treatment in all groups (p = 0.002). No unintended effects were reported. Conclusions: CO2L, RF, and ET significantly improved GSM concerning the vulvar vestibule at the 4 months follow-up.
Non-Invasive Ventilation for Community-Acquired Pneumonia: Outcomes and Predictors of Failure from an ICU Cohort
Authors: Watson Adam , Yadollahi Sina , Fahmy Alexander , Mahar Sania , Fritche Dominic , Beecham Ryan , Saeed Kordo , Dushianthan Ahilanandan
Published: December 2023

Background and Objectives: The use of non-invasive ventilation (NIV) for community-acquired pneumonia (CAP) remains controversial. NIV failure in the setting of acute hypoxemic respiratory failure is associated with increased mortality, highlighting the need for careful patient selection. Methods and Methods: This is a retrospective observational cohort study. We included 140 patients with severe CAP, treated with either NIV or invasive mechanical ventilation (IMV) as their primary oxygenation strategy. Results: The median PaO2/FiO2 ratio and SOFA score upon ICU admission were 151 mmHg and 6, respectively. We managed 76% of patients with NIV initially and report an NIV success rate of 59%. Overall, the 28-day mortality was 25%, whilst for patients with NIV success, the mortality was significantly lower at 13%. In the univariate analysis, NIV failure was associated with the SOFA score (OR 1.33), the HACOR score (OR 1.14) and the presence of septic shock (OR 3.99). The SOFA score has an AUC of 0.75 for NIV failure upon ICU admission, whilst HACOR has an AUC of 0.76 after 2 h of NIV. Conclusions: Our results suggest that a SOFA ≤ 4 and an HACOR ≤ 5 are reasonable thresholds to identify patients with severe CAP likely to benefit from NIV.
Why the Psychosomatic View on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Inconsistent with Current Evidence and Harmful to Patients
Authors: Thoma Manuel , Froehlich Laura , Hattesohl Daniel B. R. , Quante Sonja , Jason Leonard A. , Scheibenbogen Carmen
Published: December 2023

Since 1969, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been classified as a neurological disease in the International Classification of Diseases by the World Health Organization. Although numerous studies over time have uncovered organic abnormalities in patients with ME/CFS, and the majority of researchers to date classify the disease as organic, many physicians still believe that ME/CFS is a psychosomatic illness. In this article, we show how detrimental this belief is to the care and well-being of affected patients and, as a consequence, how important the education of physicians and the public is to stop misdiagnosis, mistreatment, and stigmatization on the grounds of incorrect psychosomatic attributions about the etiology and clinical course of ME/CFS.
A 10–20 GHz 6-Bit High-Accuracy Digital Step Attenuator with Low Insertion Loss in 0.15 µm GaAs p-HEMT Technology
Authors: He Ding , Yu Zhentao , Chen Jie , Du Kaiyuan , Zhu Zhiqiang , Cheng Pu , Tan Cheng
Published: December 2023

In a beamforming circuit for a modern broadband phased-array system, high accuracy and compactness have received sufficient attention as they are directly related to side lobe level and fabrication cost, respectively. In order to meet the low phase error required, this paper proposed an ultra-broadband 6-bit digital step switched-type attenuator (STA) with capacitive/inductive compensation networks. Compared to the conventional methods, the proposed technique employs an improved simplified T-structure with capacitive compensation networks, which simultaneously achieves low insertion loss and high-accuracy amplitude/phase control. In addition, on-chip level shifting circuit is integrated to avoid complex control schemes. The strategy of prioritizing return loss is adopted to alleviate the performance degradation caused by impedance mismatch after cascade. As a proof-of-principle demonstration, a wideband 6-bit STA with core area of only 0.5 mm × 1.8 mm was designed via 0.15-micrometer GaAs pHEMT technology. It exhibits ultra-broadband operation with a 31.5 dB amplitude tuning range and a 0.5 dB tuning step. The insertion loss of the reference state is 4–5.3 dB. The return loss is better than 15 dB for all the 64 states. The RMS amplitude and phase errors are less than 0.2 dB and 2° over the 10 to 20 GHz.
Crude Oil Degradation in Temperatures Below the Freezing Point by Bacteria from Hydrocarbon-Contaminated Arctic Soils and the Genome Analysis of Sphingomonas sp. AR_OL41
Authors: Semenova Ekaterina M. , Tourova Tatyana P. , Babich Tamara L. , Logvinova Ekaterina Y. , Sokolova Diyana S. , Loiko Nataliya G. , Myazin Vladimir A. , Korneykova Maria V. , Mardanov Andrey V. , Nazina Tamara N.
Published: December 2023

Intensive human activity in the Arctic region leads to hydrocarbon pollution of reservoirs and soils. Isolation of bacteria capable of growing at low temperatures and degrading oil and petroleum products is of scientific and practical value. The aim of this work was to study the physiology and growth in oil at temperatures below 0 °C of four strains of bacteria of the genera Pseudomonas, Rhodococcus, Arthrobacter, and Sphingomonas—previously isolated from diesel-contaminated soils of the Franz Josef Land archipelago—as well as genomic analysis of the Sphingomonas sp. AR_OL41 strain. The studied strains grew on hydrocarbons at temperatures from −1.5 °C to 35 °C in the presence of 0–8% NaCl (w/v). Growth at a negative temperature was accompanied by visual changes in the size of cells as well as a narrowing of the spectrum of utilized n-alkanes. The studied strains were psychrotolerant, degraded natural biopolymers (xylan, chitin) and n-alkanes of petroleum, and converted phosphates into a soluble form. The ability to degrade n-alkanes is rare in members of the genus Sphingomonas. To understand how the Sphingomonas sp. AR_OL41 strain has adapted to a cold, diesel-contaminated environment, its genome was sequenced and analyzed. The Illumina HiSeq 2500 platform was used for AR_OL41 genome strain sequencing. The genome analysis of the AR_OL41 strain showed the presence of genes encoding enzymes of n-alkane oxidation, pyruvate metabolism, desaturation of membrane lipids, and the formation of exopolysaccharides, confirming the adaptation of the strain to hydrocarbon pollution and low habitat temperature. Average nucleotide identity and digital DNA–DNA hybridization values for genomes of the AR_OL41 strain with that of the phylogenetically relative Sphingomonas alpine DSM 22537T strain were 81.9% and 20.9%, respectively, which allows the AR_OL41 strain to be assigned to a new species of the genus Sphingomonas. Phenomenological observations and genomic analysis indicate the possible participation of the studied strains in the self-purification of Arctic soils from hydrocarbons and their potential for biotechnological application in bioremediation of low-temperature environments.
Impact of Dietary Regime and Seasonality on Hindgut’s Mycobiota Diversity in Dairy Cows
Authors: Sadek Ali , Taminiau Bernard , Daube Georges , Sapountzis Panagiotis , Chaucheyras-Durand Frédérique , Castex Mathieu , Coucheney Françoise , Drider Djamel
Published: December 2023

We describe and discuss the intestinal mycobiota of dairy cows reared in France following variations in dietary regimes and two seasons. Two groups of 21 animals were followed over a summer and winter period, and another group of 28 animals was followed only during the same summer season. The summer diet was based on grazing supplemented with 3–5 kg/d of maize, grass silage and hay, while the winter diet consisted of 30% maize silage, 25% grass silage, 15% hay and 30% concentrate. A total of 69 DNA samples were extracted from the feces of these cows. Amplification and sequencing of the ITS2 region were used to assess mycobiota diversity. Analyses of alpha and beta diversity were performed and compared statistically. The mycobiota changed significantly from summer to winter conditions with a decrease in its diversity, richness and evenness parameters, while beta diversity analysis showed different mycobiota profiles. Of note, the Geotrichum operational taxonomic unit (OTU) was prevalent in the winter group, with a mean relative abundance (RA) of 65% of the total mycobiota. This Geotrichum OTU was also found in the summer group, but to a lesser extent (5%). In conclusion, a summer grazing diet allowed a higher fecal fungal diversity. These data show, for the first time, that a change in diet associated with seasonality plays a central role in shaping hindgut fungal diversity.
Genetic Loss of miR-205 Causes Increased Mammary Gland Development
Authors: Cataldo Alessandra , Cheung Douglas G. , Hagan John P. , Fassan Matteo , Sandhu-Deol Sukhinder , Croce Carlo M. , Di Leva Gianpiero , Iorio Marilena V.
Published: December 2023

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer.
Awareness and Availability of Low Sodium Iodized Salt: Results from Formative Research of Promoting Uptake of Low SodiUm Iodized Salt by Rural and Urban HousehoLds in India—The PLURAL Study
Authors: Sehgal Reena , Srinivasapura Venkateshmurthy Nikhil , Khatkar Rajesh , Konkati Shiva Prasad , Jarhyan Prashant , Sharma Manika , Ide Nicole , Prabhakaran Dorairaj , Mohan Sailesh
Published: December 2023

Dietary sodium intake is high among adults in India. Use of low sodium iodized salt (LSIS) can help reduce sodium intake. However, contextually relevant and culturally appropriate interventions to promote LSIS uptake in India have not been developed and implemented. We carried out formative research to inform an intervention to promote uptake of LSIS among rural and urban households in north (Sonipat district) and south (Visakhapatnam and Anakapalli districts) India. Sixty-two in-depth interviews of six focus groups were held with a range of stakeholders—consumers, retailers and influencers. Participant views on availability, affordability, taste and safety of LSIS, along with views on hypertension, its risk factors and potential intervention design and delivery strategies were elicited. Thematic analysis of the data was carried out. While the awareness of hypertension and its risk factors was high among the participants, awareness of LSIS was low. There was also low demand for, and availability of, LSIS. Since cost of LSIS was higher than regular salt, participants preferred that a subsidy be provided to offset the cost. Based on these findings, an intervention to promote the uptake of LSIS was implemented by project staff using various educational materials such as posters, pamphlets and short videos.
Distributions and Trends of the Global Burden of Colorectal Cancer Attributable to Dietary Risk Factors over the Past 30 Years
Authors: Liang Yuxing , Zhang Nan , Wang Miao , Liu Yixin , Ma Linlu , Wang Qian , Yang Qian , Liu Xiaoyan , Zhou Fuling , Wei Yongchang
Published: December 2023

Dietary risk has always been a major risk factor for colorectal cancer (CRC). However, the contribution of dietary risk factors to CRC at the level of region, gender, and age has not been fully characterized. Based on the Global Burden of Disease (GBD) 2019 study, the death rates, age-standardized mortality rates (ASDRs), and estimated annual percentage changes (EAPCs) were calculated to assess the trends of CRC attributable to dietary risk factors over the past 30 years. Globally, the death cases of CRC increased to 1,085,797 in 2019, and the number of deaths attributed to dietary risk factors increased to 365,752 in 2019, representing approximately one-third of all CRC-related fatalities. Overall, the ASDR attributable to dietary risks was 4.61 per 100,000 in 2019, with a slight downward trend (EAPC = −0.29). Notably, there is a rising trend in early-onset colorectal cancer mortality associated with dietary factors. To alleviate CRC burdens, it is recommended to elevate the intake of whole grains, milk, calcium, and fiber while reducing consumption of red and processed meats. The results will improve the understanding, and provide guidance on the diet of CRC in different regions, gender, and age groups worldwide.
Correction: D’Amico et al. Consumption of Cashew (Anacardium occidentale L.) Nuts Counteracts Oxidative Stress and Tissue Inflammation in Mild Hyperhomocysteinemia in Rats. Nutrients 2022, 14, 1474
Authors: D’Amico Ramona , Cordaro Marika , Fusco Roberta , Peritore Alessio Filippo , Genovese Tiziana , Gugliandolo Enrico , Crupi Rosalia , Mandalari Giuseppina , Caccamo Daniela , Cuzzocrea Salvatore , Di Paola Rosanna , Siracusa Rosalba , Impellizzeri Daniela
Published: December 2023

In the original publication [...]
Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition
Authors: González-Lamuño Domingo , Arrieta-Blanco Francisco Jesús , Fuentes Elena Dios , Forga-Visa María Teresa , Morales-Conejo Monstserrat , Peña-Quintana Luis , Vitoria-Miñana Isidro
Published: December 2023

Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for various significant medical conditions, yet controversy persists around its assessment and management. The diagnosis of disorders afffecting homocysteine (Hcy) metabolism faces delays due to insufficient awareness of its clinical presentation and unique biochemical characteristics. In cases of arterial or venous thrombotic vascular events, particularly with other comorbidities, it is crucial to consider moderate to severe HHcy. A nutritional approach to HHcy management involves implementing dietary strategies and targeted supplementation, emphasizing key nutrients like vitamin B6, B12, and folate that are crucial for Hcy conversion. Adequate intake of these vitamins, along with betaine supplementation, supports Hcy remethylation. Lifestyle modifications, such as smoking cessation and regular physical activity, complement the nutritional approach to enhance Hcy metabolism. For individuals with HHcy, maintaining a plasma Hcy concentration below 50 μmol/L consistently is vital to lowering the risk of vascular events. Collaboration with healthcare professionals and dietitians is essential for developing personalized dietary plans addressing the specific needs and underlying health conditions. This integrated approach aims to optimize metabolic processes and reduce the associated health risks.