bluuebunny/crossref_metadata_2025 huggingface dataset:
Punching behavior of BubbleDeck type reinforced concrete slabs
Authors: Nicácio Wanderley G. , Barros Joaquim A. O. , Melo Guilherme S. S. A.
Published: October 2019

The BubbleDeck type slab (BD) is a reinforced concrete (RC) flat slab that includes recycled plastic hollow spheres (RPHS) in its core for decreasing its dead weight. However, punching capacity of BD slabs can be a critical aspect, thereby this work is devoted to assess experimentally its punching behavior. An experimental program composed of four real scale prototypes, representative of RC flat slabs in punching loading conditions, was carried out. Two of these slabs are of BD type, while the other two do not include the RPHS system, herein denominated as RC solid slab (SS). The test results show that all the tested slabs failed in punching after the occurrence of yield initiation of the flexural reinforcement. The punching capacity and the deflection at failure of BD type slab has decreased up to 14% and up to 44%, respectively, when compared to the corresponding SS type slab. A relatively small ductility index was obtained (between 1.51 and 2.65). In BD type slabs, the punching failure surface had tendency to propagate through the RPHS, at an inclination angle of about 45°.
The Hydrothermal Synthesis of Sulfate Cancrinite (SO4‐CAN): Relations between Si‐Al Sources and Crystal Quality
Authors: Buhl Josef‐Christian , Petrov Valeriy
Published: October 2019

Sulfate cancrinite (SO4‐CAN) Na8[AlSiO4]6(SO4)(H2O)n (2.6 < n < 3.2) was synthesized under hydrothermal conditions at 200 °C and 48 hours. Three different Si‐Al sources were inserted: (a) kaolinite (K), (b) a gel of sodium‐waterglass and sodium aluminate (G), and (c) an oxide mixture of cristobalite and corundum (CK). The products were characterized by X‐ray powder diffraction (XRD), 29Si and 27Al MAS NMR spectroscopy, scanning electron microscopy (SEM), energy dispersive X‐ray spectroscopy (EDXS) and BET surface area analysis as well as simultaneous thermoanalysis (TG‐DTA). Mostly nanocrystals of platelet habit and dimensions smaller than 100 nm (beside a very few larger crystals) were observed from K. In contrast the gel (G) yielded to cancrinites with typical rod‐like morphology and dimensions of 100 × 500 nm. Large prismatic cancrinites up to 5 μm width and 10 μm length were observed from the oxide mixture CK. Furthermore the transition kinetics of the cancrinites into nosean was investigated at a temperature of 1000 °C under open conditions. This process was already complete after 1 hour for the nanocrystals from K but needed 10 hours for the nanocrystals from G and the microcrystals from CK. The relations between the individual Si‐Al source and the crystal properties like size, habit, and thermal transition kinetics were discussed.
Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models
Authors: Oesch F. , Fabian E. , Landsiedel Robert
Published: October 2019

The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the organism, is crucial for inhaled compounds entering this organ intentionally (e.g. drugs) and unintentionally (e.g. work place and environmental compounds). Additionally, local metabolism by enzymes preferentially or exclusively occurring in the lung is important for favorable or toxic effects of xenobiotics entering the organism also by routes other than by inhalation. The data collected in this review show that generally activities of cytochromes P450 are low in the lung of all investigated species and in vitro models. Other oxidoreductases may turn out to be more important, but are largely not investigated. Phase II enzymes are generally much higher with the exception of UGT glucuronosyltransferases which are generally very low. Insofar as data are available the xenobiotic metabolism in the lung of monkeys comes closed to that in the human lung; however, very few data are available for this comparison. Second best rate the mouse and rat lung, followed by the rabbit. Of the human in vitro model primary cells in culture, such as alveolar macrophages and alveolar type II cells as well as the A549 cell line appear quite acceptable. However, (1) this generalization represents a temporary oversimplification born from the lack of more comparable data; (2) the relative suitability of individual species/models is different for different enzymes; (3) when more data become available, the conclusions derived from these comparisons quite possibly may change.
Plemelj–Sokhotski isomorphism for quasicircles in Riemann surfaces and the Schiffer operators
Authors: Schippers Eric , Staubach Wolfgang
Published: October 2019

Let R be a compact Riemann surface and $$\Gamma $$
Γ
be a Jordan curve separating R into connected components $$\Sigma _1$$

Σ
1

and $$\Sigma _2$$

Σ
2

. We consider Calderón–Zygmund type operators $$T(\Sigma _1,\Sigma _k)$$

T
(

Σ
1

,

Σ
k

)

taking the space of $$L^2$$

L
2

anti-holomorphic one-forms on $$\Sigma _1$$

Σ
1

to the space of $$L^2$$

L
2

holomorphic one-forms on $$\Sigma _k$$

Σ
k

for $$k=1,2$$

k
=
1
,
2

, which we call the Schiffer operators. We extend results of Max Schiffer and others, which were confined to analytic Jordan curves $$\Gamma $$
Γ
, to general quasicircles, and prove new identities for adjoints of the Schiffer operators. Furthermore, let V be the space of anti-holomorphic one-forms which are orthogonal to $$L^2$$

L
2

anti-holomorphic one-forms on R with respect to the inner product on $$\Sigma _1$$

Σ
1

. We show that the restriction of the Schiffer operator $$T(\Sigma _1,\Sigma _2)$$

T
(

Σ
1

,

Σ
2

)

to V is an isomorphism onto the set of exact holomorphic one-forms on $$\Sigma _2$$

Σ
2

. Using the relation between this Schiffer operator and a Cauchy-type integral involving Green’s function, we also derive a jump decomposition (on arbitrary Riemann surfaces) for quasicircles and initial data which are boundary values of Dirichlet-bounded harmonic functions and satisfy the classical algebraic constraints. In particular we show that the jump operator is an isomorphism on the subspace determined by these constraints.
RVD induction and autologous stem cell transplantation followed by lenalidomide maintenance in newly diagnosed multiple myeloma: a phase 2 study of the Finnish Myeloma Group
Authors: Luoma Sini , Anttila Pekka , Säily Marjaana , Lundan Tuija , Heiskanen Jouni , Siitonen Timo , Kakko Sakari , Putkonen Mervi , Ollikainen Hanna , Terävä Venla , Sankelo Marja , Partanen Anu , Launonen Kirsi , Räsänen Anu , Sikiö Anu , Suominen Merja , Bazia Piotr , Kananen Kristiina , Lievonen Juha , Selander Tuomas , Pelliniemi Tarja-Terttu , Ilveskero Sorella , Huotari Virva , Mäntymaa Pentti , Tienhaara Anri , Jantunen Esa , Silvennoinen Raija
Published: October 2019

Autologous stem cell transplantation (ASCT) combined with novel agents is the standard treatment for transplant-eligible, newly diagnosed myeloma (NDMM) patients. Lenalidomide is approved for maintenance after ASCT until progression, although the optimal duration of maintenance is unknown. In this trial, 80 patients with NDMM received three cycles of lenalidomide, bortezomib, and dexamethasone followed by ASCT and lenalidomide maintenance until progression or toxicity. The primary endpoint was the proportion of flow-negative patients. Molecular response was assessed if patients were flow-negative or in stringent complete response (sCR). By intention to treat, the overall response rate was 89%. Neither median progression-free survival nor overall survival (OS) has been reached. The OS at 3 years was 83%. Flow-negativity was reached in 53% and PCR-negativity in 28% of the patients. With a median follow-up of 27 months, 29 (36%) patients are still on lenalidomide and 66% of them have sustained flow-negativity. Lenalidomide maintenance phase was reached in 8/16 high-risk patients but seven of them have progressed after a median of only 6 months. In low- or standard-risk patients, the outcome was promising, but high-risk patients need more effective treatment approach. Flow-negativity with the conventional flow was an independent predictor for longer PFS.
Therapies to limit myocardial injury in animal models of myocarditis: a systematic review and meta-analysis
Authors: Silverblatt Joshua A. , Ziff Oliver J. , Dancy Luke , Daniel Allen , Carter Ben , Scott Paul , Sado Daniel M. , Shah Ajay , Bromage Daniel I.
Published: October 2019

Current myocarditis guidelines do not advocate treatment to prevent myocardial injury and scar deposition in patients with myocarditis and normal left ventricular ejection fraction. We aimed to ascertain the utility of beta blockers, calcium channel blockers and antagonists of the renin–angiotensin system in ameliorating myocardial injury, scar formation and calcification in animal in vivo models of myocarditis. The project was prospectively registered with the PROSPERO database of systematic reviews (CRD42018089336). Primary outcomes (necrosis, fibrosis and calcification) were meta-analysed with random-effects modelling. 52 studies were systematically reviewed. Meta-analysis was performed compared with untreated controls. In each study, we identified all independent comparisons of treatment versus control groups. The pooled weighted mean difference (WMD) indicated treatment reduced necrosis by 16.9% (71 controlled analyses, 95% CI 13.2–20.7%; P < 0.001), however there was less evidence of an effect after accounting for publication bias. Treatment led to a 12.8% reduction in fibrosis (73 controlled analyses, 95% CI 7.6–18.0%; P < 0.001). After accounting for publication bias this was attenuated to 7.8% but remained significant. Treatment reduced calcification by 4.1% (28 controlled analyses, 95% CI 0.2–8.0%; P < 0.0395). We observed significant heterogeneity in effect size in all primary endpoints, which was predominantly driven by differences between drug categories. Beta blockers and angiotensin-converting enzyme (ACE) inhibitors were the only agents that were effective for both necrosis and fibrosis, while only ACE inhibitors had a significant effect on calcification. This study provides evidence for a role for ACE inhibitors and beta blockers to prevent myocardial injury and scar deposition in in vivo models of myocarditis. There is a need for further well-designed studies to assess the translational application of these treatments.
Preservation of residual hearing after cochlear implant surgery with slim modiolar electrode
Authors: Iso-Mustajärvi Matti , Sipari Sini , Löppönen Heikki , Dietz Aarno
Published: October 2019

Purpose

To evaluate the insertion results and hearing preservation of a novel slim modiolar electrode (SME) in patients with residual hearing.

Methods

We retrospectively collected the data from the medical files of 17 patients (18 ears) implanted with a SME. All patients had functional low frequency hearing (PTA (0.125–0.5 kHz) ≤ 80 dB HL). The insertion results were re-examined from the postoperative cone-beam computed tomography scans. Postoperative thresholds were obtained at the time of switch-on of the sound processors (mean 43 days) and at latest follow-up (mean 582 days). The speech recognition in noise was measured with the Finnish matrix sentence test preoperatively and at follow-up.

Results

The mean insertion depth angle (IDA) was 395°. Neither scala dislocations nor tip fold over were detected. There were no total hearing losses. Functional low-frequency hearing was preserved in 15/18 (83%) ears at switch-on and in 14/17 (82%) ears at follow-up. According to HEARRING classification, 55% (10/18) had complete HP at switch-on and 41% (7/17) still at follow-up. Thirteen patients (14 ears) were initially fitted with electric–acoustic stimulation and seven patients (8 ears) continued to use it after follow-up.

Conclusions

The preliminary hearing preservation results with the SME were more favorable than reported for other perimodiolar electrodes. The results show that the array may also be feasible for electro-acoustic stimulation; it is beneficial in that it provides adequate cochlear coverage for pure electrical stimulation in the event of postoperative or progressive hearing loss.
Fat oxidation at rest and during exercise in male monozygotic twins
Authors: Karppinen Jari E. , Rottensteiner Mirva , Wiklund Petri , Hämäläinen Kaisa , Laakkonen Eija K. , Kaprio Jaakko , Kainulainen Heikki , Kujala Urho M.
Published: October 2019

Purpose

We aimed to investigate if hereditary factors, leisure-time physical activity (LTPA) and metabolic health interact with resting fat oxidation (RFO) and peak fat oxidation (PFO) during ergometer cycling.

Methods

We recruited 23 male monozygotic twin pairs (aged 32–37 years) and determined their RFO and PFO with indirect calorimetry for 21 and 19 twin pairs and for 43 and 41 twin individuals, respectively. Using physical activity interviews and the Baecke questionnaire, we identified 10 twin pairs as LTPA discordant for the past 3 years. Of the twin pairs, 8 pairs participated in both RFO and PFO measurements, and 2 pairs participated in either of the measurements. We quantified the participants’ metabolic health with a 2-h oral glucose tolerance test.

Results

Fat oxidation within co-twins was correlated at rest [intraclass correlation coefficient (ICC) = 0.54, 95% confidence interval (CI) 0.15–0.78] and during exercise (ICC = 0.67, 95% CI 0.33–0.86). The LTPA-discordant pairs had no pairwise differences in RFO or PFO. In the twin individual-based analysis, PFO was positively correlated with the past 12-month LTPA (r = 0.26, p = 0.034) and the Baecke score (r = 0.40, p = 0.022) and negatively correlated with the area under the curve of insulin (r = − 0.42, p = 0.015) and glucose (r = − 0.31, p = 0.050) during the oral glucose tolerance test.

Conclusions

Hereditary factors were more important than LTPA for determining fat oxidation at rest and during exercise. Additionally, PFO, but not RFO, was associated with better metabolic health.
Non-Monochromatic and Conflict-Free Colorings on Tree Spaces and Planar Network Spaces
Authors: Aronov Boris , de Berg Mark , Markovic Aleksandar , Woeginger Gerhard
Published: October 2019

It is well known that any set of n intervals in $$\mathbb {R} ^1$$R1 admits a non-monochromatic coloring with two colors and a conflict-free coloring with three colors. We investigate generalizations of this result to colorings of objects in more complex 1-dimensional spaces, namely so-called tree spaces and planar network spaces.
Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds)
Authors: Szabó István , Varga Csaba
Published: October 2019

Medicinal thermal waters consist of a mixture of different organic and inorganic compounds. Traditionally, these waters are only characterized and classified by their inorganic composition; however, the bioavailability of the majority of these inorganic compounds is limited. Many authors investigate the organic fractions of thermal waters. These authors propose that these compounds have a potential effect on health. To elucidate the underlying mechanisms, it is crucial to know the composition of the organic fractions. The absorption of these compounds on intact skin or mucosa is notable. Some of them have local anaesthetic effect or affect receptors in the central nervous system. In the knowledge of the chemical composition, we are able to estimate the possible pharmacological effect or might be able to assess possible toxicity risks. In the present article, we aim to review possible health effects of two of the identified organic fractions: benzene and alkylbenzenes and phenolic compounds that might correlate with the therapeutic effect on rheumatological or other diseases.
Long-term standardized forest phenology in Sweden: a climate change indicator
Authors: Langvall Ola , Ottosson Löfvenius Mikaell
Published: October 2019

Because climate change alters patterns of vegetative growth, long-term phenological measurements and observations can provide important data for analyzing its impact. Phenological assessments are usually made as records of calendar dates when specific phase changes occur. Such assessments have benefits and are used in Citizen Science monitoring. However, these kinds of data often have low statistical precision when describing gradual changes. Frequent monitoring of the phenological traits of forest trees and berries as they undergo gradual change is needed to acquire good temporal resolution of transitions relative to other factors, such as susceptibility to frosts, insects, and fungi, and the use of berries as a food resource. Intensive weekly monitoring of the growth of apical and branch buds and the elongation of shoots and leaves on four tree species, and the abundance of flowers and berries of bilberry and lingonberry, has been performed in Sweden since 2006. Here, we present quantitative methods for interpolating such data, which detail the gradual changes between assessments in order to describe average rates of development and amount of interannual variation. Our analysis has shown the active growth period of trees to differ with latitude. We also observed a change in the timing of the maximum numbers of ripening berries and their successive decline. Data from tree phenology assessments can be used to recommend best forestry practice and to model tree growth, while berry data can be used to estimate when food resources for animals are most available.
Parallelized microscale fed-batch cultivation in online-monitored microtiter plates: implications of media composition and feed strategies for process design and performance
Authors: Morschett Holger , Jansen Roman , Neuendorf Christian , Moch Matthias , Wiechert Wolfgang , Oldiges Marco
Published: October 2019

Limited throughput represents a substantial drawback during bioprocess development. In recent years, several commercial microbioreactor systems have emerged featuring parallelized experimentation with optical monitoring. However, many devices remain limited to batch mode and do not represent the fed-batch strategy typically applied on an industrial scale. A workflow for 32-fold parallelized microscale cultivation of protein secreting Corynebacterium glutamicum in microtiter plates incorporating online monitoring, pH control and feeding was developed and validated. Critical interference of the essential media component protocatechuic acid with pH measurement was revealed, but was effectively resolved by 80% concentration reduction without affecting biological performance. Microfluidic pH control and feeding (pulsed, constant and exponential) were successfully implemented: Whereas pH control improved performance only slightly, feeding revealed a much higher optimization potential. Exponential feeding with µ = 0.1 h−1 resulted in the highest product titers. In contrast, other performance indicators such as biomass-specific or volumetric productivity resulted in different optimal feeding regimes.
Impacts of wolves on rural economies from recreational small game hunting
Authors: Pedersen Simen , Angelstam Per , Ferguson Michael A.D. , Wabakken Petter , Storaas Torstein
Published: October 2019

Centralized management of large carnivore populations in rural and remote landscapes used by local people often leads to conflicts between the objectives of wildlife conservation and rural development. We tested the hypothesis that the presence of wolves indirectly reduces landowner revenues from traditional small game hunting, and that landowner revenues are more variable closer to wolf territories. The assumed mechanism is that hunters fear that their economically and culturally valuable hunting dogs may be killed by wolves, which results in reduced hunting, and thus reduced revenues for landowners where and when wolves occur. To determine the effect of wolf presence on revenues from sport hunting, we obtained data from 1990 to 2009 on income from small game management areas, in Hedmark and Oppland Counties in Norway, as well as  locations of wolf territories. Small game management areas experienced increased sport hunting revenue with increasing distance to the closest wolf territory. Also, inter-annual variation in revenue decreased with increasing distance from wolf territories. Thus, wolf presence may reduce landowners’ revenues from small game hunting, and cause higher economic variability in rural communities. It is important to note that while the economic impacts of wolves may be compensated where governments have the will and the economic resources, the impacts on the lifestyles of rural people (e.g. hunter’s fear of losing prized dogs to wolves) will remain controversial.
Patients’ Satisfaction with HIV Care Providers in Public Health Facilities in Lusaka: A Study of Patients who were Lost-to-Follow-Up from HIV Care and Treatment
Authors: Mukamba Njekwa , Chilyabanyama Obvious N. , Beres Laura K. , Simbeza Sandra , Sikombe Kombatende , Padian Nancy , Holmes Charles , Sikazwe Izukanji , Geng Elvin , Schwartz Sheree R.
Published: October 2019

Prognosis among those who are HIV infected has improved but long-term retention is challenging. Health systems may benefit from routinely measuring patient satisfaction which is a potential driver of engagement in HIV care, but it is not often measured in Africa, and Zambia in particular. This study aims to internally validate a patient satisfaction tool, assess satisfaction among patients previously lost-to-follow up (LTFU) from HIV care in Lusaka province and to measure association between patient satisfaction with their original clinic and re-engagement in HIV care. A cross-sectional assessment of satisfaction was conducted by tracing sampled patients drawn from public health facilities. Our findings suggest that satisfaction tool, previously validated in USA, exhibits high internal consistency for measuring patient satisfaction in the Zambian health system. Patient satisfaction with healthcare providers is associated with re-engagement in HIV care. Future interventions on patient-centred care are likely to optimize and support retention in care.
Impact of Fraxinus excelsior dieback on biota of ash-associated lichen epiphytes at the landscape and community level
Authors: Łubek Anna , Kukwa Martin , Czortek Patryk , Jaroszewicz Bogdan
Published: October 2019

The landscape-scale extinction of a tree species may have a negative impact on diversity of associated epiphytic species. We used ordination and hierarchical clustering methods to assess landscape and the community level effects of reduction in the abundance of European ash Fraxinus excelsior, caused by ash dieback, on the associated epiphytic lichen biota in Białowieża Forest (Poland)—the best preserved forest complex in Central Europe. At the landscape level ash decline impact on the biota of ash-associated epiphytic lichens was weak, due to the high diversity of tree species, which may serve as potential alternative hosts. At this level, oak and hornbeam are the most important alternative hosts, assuring the maintenance of ash-associated epiphytic lichens. Lime, alder, and hazel appeared to be less important but still may serve as substitute phorophytes to approximately 2/3 of the ash-associated lichen biota. About 90% of epiphytic biota are likely to survive on the landscape scale. However, at the community level of alder-ash floodplain forest, where ash was dominant, about 50% of ash-associated epiphytic lichen species are threatened by ash dieback. Our results highlight the importance of a spatial scale in conservation biology. Protection of large forest areas with rich diversity of phorophyte trees increases chances of survival of the associated epiphytic organisms.
Moisture-induced crossover in the thermodynamic and mechanical response of hydrophilic biopolymer
Authors: Zhang Chi , Coasne Benoit , Guyer Robert , Derome Dominique , Carmeliet Jan
Published: October 2019

The use of natural sustainable resources such as wood in green industrial processes is currently limited by our poor understanding of the impact of moisture on their thermodynamic and mechanical behaviors. Here, a molecular dynamics approach is used to investigate the physical response of a typical hydrophilic biopolymer in softwood hemicellulose—xylan—when subjected to moisture adsorption. A unique moisture-induced crossover is found in the thermodynamic and mechanical properties of this prototypical biopolymer with many quantities such as the heat of adsorption, heat capacity, thermal expansion and elastic moduli exhibiting a marked evolution change for a moisture content about 30 wt%. By investigating the microscopic structure of the confined water molecules and the polymer–water interfacial area, the molecular mechanism responsible for this crossover is shown to correspond to the formation of a double-layer adsorbed film along the amorphous polymeric chains. In addition to this moisture-induced crossover, many properties of the hydrated biopolymer are found to obey simple material models.
Climate finance and disclosure for institutional investors: why transparency is not enough
Authors: Ameli Nadia , Drummond Paul , Bisaro Alexander , Grubb Michael , Chenet Hugues
Published: October 2019

The finance sector’s response to pressures around climate change has emphasized disclosure, notably through the recommendations of the Financial Stability Board’s Task Force on Climate-related Financial Disclosures (TCFD). The implicit assumption—that if risks are fully revealed, finance will respond rationally and in ways aligned with the public interest—is rooted in the “efficient market hypothesis” (EMH) applied to the finance sector and its perception of climate policy. For low carbon investment, particular hopes have been placed on the role of institutional investors, given the apparent matching of their assets and liabilities with the long timescales of climate change. We both explain theoretical frameworks (grounded in the “three domains”, namely satisficing, optimizing, and transforming) and use empirical evidence (from a survey of institutional investors), to show that the EMH is unsupported by either theory or evidence: it follows that transparency alone will be an inadequate response. To some extent, transparency can address behavioural biases (first domain characteristics), and improving pricing and market efficiency (second domain); however, the strategic (third domain) limitations of EMH are more serious. We argue that whilst transparency can help, on its own it is a very long way from an adequate response to the challenges of ‘aligning institutional climate finance’.
Technological Competition, Innovation Motive and Corporate Social Responsibility: Evidence from Top Managers of European SMEs
Authors: Graafland Johan , Noorderhaven Niels
Published: October 2019

Various motives have been proposed for firms to engage in corporate social responsibility (CSR), but no attention has been paid to innovation as a motive to engage in CSR. In this paper we explore the role of this motive and hypothesize that it is particularly important for companies facing intensive technological competition. We find support for this in a sample of 2579 top managers of small and medium sized enterprises from 12 European countries. The innovation motive mediates the relationship between technological competition and CSR and is the most (second most) important motive for environmental and social CSR, respectively.
Spontaneous hybrids of Prunus fruticosa Pall. in Hungary
Authors: Hrotkó K. , Feng Y. , Halász J.
Published: October 2019

The European ground cherry (Prunus fruticosa Pall.) as a potential dwarfing rootstock attracted the attention of cherry rootstock researchers in several breeding projects. In order to clarify some doubtful classification of collected and promising specimen of supposed hybrids, we compared morphological characteristics to literature data. Genetic analysis was also undertaken using simple-sequence repeat markers. Our results suggest that the investigated P. fruticosa forma fruticosa specimens are tetraploid and the genetic analysis did not contribute to distinguish the P. fruticosa forma fruticosa and forma aucta. Based on morphological characters, we identified few specimens of spontaneous hybrid P. fruticosa × P. mahaleb (P. × jávorkae). Our genetic analysis supports the hypothesis that the sample shrub is triploid and show genetic relationship with P. mahaleb. This triploid hybrid due to the flower sterility represents a blind alley in its evolution. We identified from each investigated habitat specimens of supposed hybrid derivatives of ground cherry P. fruticosa × P. avium (P. × mohácsyana). This hybrid clearly showed distinct morphological characteristics, easily distinguishable from the P. fruticosa f. fruticosa and f. aucta and the genetic analysis suggests that the accessions are triploid. The flower sterility limits the usage of this hybrid derivative for further cross-breeding but allows usage as clonal cherry rootstock. Our genetic analysis suggests that samples of P. × eminens are tetraploid, fertile hybrid derivative of ground cherry occurring in some habitats of the basic species and show similar morphological characters to the cultivated sour cherry.
The average covering tree value for directed graph games
Authors: Khmelnitskaya Anna , Selçuk Özer , Talman Dolf
Published: October 2019

We introduce a single-valued solution concept, the so-called average covering tree value, for the class of transferable utility games with limited communication structure represented by a directed graph. The solution is the average of the marginal contribution vectors corresponding to all covering trees of the directed graph. The covering trees of a directed graph are those (rooted) trees on the set of players that preserve the dominance relations between the players prescribed by the directed graph. The average covering tree value is component efficient, and under a particular convexity-type condition it is stable. For transferable utility games with complete communication structure the average covering tree value equals to the Shapley value of the game. If the graph is the directed analog of an undirected graph the average covering tree value coincides with the gravity center solution.
Post-disturbance recovery of forest cover and tree height differ with management in Central Europe
Authors: Senf Cornelius , Müller Jörg , Seidl Rupert
Published: October 2019

Context

Recovery from disturbances is a prominent measure of forest ecosystem resilience, with swift recovery indicating resilient systems. The forest ecosystems of Central Europe have recently been affected by unprecedented levels of natural disturbance, yet our understanding of their ability to recover from disturbances is still limited.

Objectives

We here integrated satellite and airborne Lidar data to (i) quantify multi-decadal post-disturbance recovery of two indicators of forest structure, and (ii) compare the recovery trajectories of forest structure among managed and un-managed forests.

Methods

We developed satellite-based models predicting Lidar-derived estimates of tree cover and stand height at 30 m grain across a 3100 km2 landscape in the Bohemian Forest Ecosystem (Central Europe). We summarized the percentage of disturbed area that recovered to > 40% tree cover and > 5 m stand height and quantified the variability in both indicators over a 30-year period. The analyses were stratified by three management regimes (managed, protected, strictly protected) and two forest types (beech-dominated, spruce-dominated).

Results

We found that on average 84% of the disturbed area met our recovery threshold 30 years post-disturbance. The rate of recovery was slower in un-managed compared to managed forests. Variability in tree cover was more persistent over time in un-managed forests, while managed forests strongly converged after a few decades post-disturbance.

Conclusion

We conclude that current management facilitates the recovery of forest structure in Central European forest ecosystems. However, our results underline that forests recovered well from disturbances also in the absence of human intervention. Our analysis highlights the high resilience of Central European forest ecosystems to recent disturbances.
How to be a deontic buck-passer
Authors: Metz Euan K. H.
Published: October 2019

Deontic, as opposed toevaluativebuck-passing theories seem to be easier to accept, since there appears to be an intimate connection between deontic properties, such as ‘ought’, ‘requirement’, and ‘permission’ on the one hand, and normative reasons on the other. However, it is far from obvious what, precisely, the connection consists in, and this topic has suffered from a paucity of discussion. This paper seeks to address that paucity by providing a novel deontic buck-passing view, one that avoids the pitfalls both of the most straightforward view on the matter (what I call the “standard view”) as well as a recently articulated view, due to Matt Bedke. It does so by appealing first to the distinction between a reason for, and a reason against, and uses this distinction to clarify what are taken to be two fundamental, but distinct, deontic properties—oughtandrequirement. The resulting view allows us to capture these properties, the structural relations between them, and does so in a way that avoids making supererogation impossible.
Naturalism, tractability and the adaptive toolbox
Authors: Rich Patricia , Blokpoel Mark , de Haan Ronald , Otworowska Maria , Sweers Marieke , Wareham Todd , van Rooij Iris
Published: October 2019

Many compelling examples have recently been provided in which people can achieve impressive epistemic success, e.g. draw highly accurate inferences, by using simple heuristics and very little information. This is possible by taking advantage of the features of the environment. The examples suggest an easy and appealing naturalization of rationality: on the one hand, people clearlycanapply simple heuristics, and on the other hand, they intuitivelyoughtdo so when this brings them high accuracy at little cost.. The ‘ought-can’ principle is satisfied, and rationality is meaningfully normative. We show, however, that this naturalization program is endangered by a computational wrinkle in the adaptation process taken to be responsible for this heuristics-based (‘ecological’) rationality: for the adaptation process to guarantee even minimal rationality, it requires astronomical computational resources, making the problem intractable. We consider various plausible auxiliary assumptions in attempt to remove this obstacle, and show that they do not succeed; intractability is a robust property of adaptation. We discuss the implications of our findings for the project of naturalizing rationality.
Fractional-Flow Theory for Non-Newtonian Surfactant-Alternating-Gas Foam Processes
Authors: Salazar Castillo Rodrigo O. , Ter Haar Sterre F. , Ponners Christopher G. , Bos Martijn , Rossen William
Published: October 2019

Foam can improve sweep efficiency in gas-injection-enhanced oil recovery. Surfactant-alternating-gas (SAG) is a favored method of foam injection. Laboratory data indicate that foam can be non-Newtonian at low water fractional flowfw, and therefore during gas injection in a SAG process. We investigate the implications of this finding for mobility control and injectivity, by extending fractional-flow theory to gas injection in a non-Newtonian SAG process in radial flow. We make most of the standard assumptions of fractional-flow theory (incompressible phases, one-dimensional displacement through a homogeneous reservoir, instantaneous attainment of local equilibrium), excluding Newtonian mobilities. For this initial study, we ignore the effect of changing or non-uniform oil saturation on foam. Non-Newtonian behavior at lowfwimplies that the limiting water saturation for foam stability varies as superficial velocity decreases with radial distance from the well. We discretize the domain radially and perform Buckley–Leverett analysis on each narrow increment in radius. Solution characteristics move outward with fixedfw. We base the foam model parameters and non-Newtonian behavior on laboratory data in the absence of oil. We compare results to mobility and injectivity determined by conventional simulation, where grid resolution is usually limited. For shear-thinning foam, mobility control improves as the foam front propagates from the well, but injectivity declines somewhat with time. This change in mobility ratio is not that at steady state at fixed water fractional flow in the laboratory, however, because the shock front in a non-Newtonian SAG process does not propagate at fixed fractional flow (though individual characteristics do). Moreover, the shock front is not governed by the conventional condition of tangency to the fractional-flow curve, though it continually approaches this condition. Injectivity benefits from the increased mobility of shear-thinning foam near the well. The foam front, which maintains a constant dimensionless velocity for Newtonian foam, decelerates somewhat with time for shear-thinning foam. For shear-thickening foam, mobility control deteriorates as the foam front advances, though injectivity improves somewhat with time. Overall, however, injectivity suffers from reduced foam mobility at high superficial velocity near the well. The foam front accelerates somewhat with time. Conventional simulators cannot adequately represent these effects, or estimate injectivity accurately, in the absence of extraordinarily fine grid resolution near the injection well.
Deep Learning for Generic Object Detection: A Survey
Authors: Liu Li , Ouyang Wanli , Wang Xiaogang , Fieguth Paul , Chen Jie , Liu Xinwang , Pietikäinen Matti
Published: October 2019

Object detection, one of the most fundamental and challenging problems in computer vision, seeks to locate object instances from a large number of predefined categories in natural images. Deep learning techniques have emerged as a powerful strategy for learning feature representations directly from data and have led to remarkable breakthroughs in the field of generic object detection. Given this period of rapid evolution, the goal of this paper is to provide a comprehensive survey of the recent achievements in this field brought about by deep learning techniques. More than 300 research contributions are included in this survey, covering many aspects of generic object detection: detection frameworks, object feature representation, object proposal generation, context modeling, training strategies, and evaluation metrics. We finish the survey by identifying promising directions for future research.
Etiology-Based Classification of Adjacent Segment Disease following Lumbar Spine Fusion
Authors: Louie Philip K. , Harada Garrett K. , Sayari Arash J. , Mayo Benjamin C. , Khan Jannat M. , Varthi Arya G. , Yacob Alem , Samartzis Dino , An Howard S.
Published: October 2019

Background

Adjacent segment disease (ASDz) is a potential complication following lumbar spinal fusion. A common nomenclature based on etiology and ASDz type does not exist and is needed to assist with clinical prognostication, decision making, and management.

Questions/Purposes

The objective of this study was to develop an etiology-based classification system for ASDz following lumbar fusion.

Methods

We conducted a retrospective chart review of 65 consecutive patients who had undergone both a lumbar fusion performed by a single surgeon and a subsequent procedure for ASDz. We established an etiology-based classification system for lumbar ASDz with the following six categories: “degenerative” (degenerative disc disease or spondylosis), “neurologic” (disc herniation, stenosis), “instability” (spondylolisthesis, rotatory subluxation), “deformity” (scoliosis, kyphosis), “complex” (fracture, infection), or “combined.” Based on this scheme, we determined the rate of ASDz in each etiologic category.

Results

Of the 65 patients, 27 (41.5%) underwent surgery for neurogenic claudication or radiculopathy for adjacent-level stenosis or disc herniation and were classified as “neurologic.” Ten patients (15.4%) had progressive degenerative disc pathology at the adjacent level and were classified as “degenerative.” Ten patients (15.4%) had spondylolisthesis or instability and were classified as “instability,” and three patients (4.6%) required revision surgery for adjacent-level kyphosis or scoliosis and were classified as “deformity.” Fifteen patients (23.1%) had multiple diagnoses that included a combination of categories and were classified as “combined.”

Conclusion

This is the first study to propose an etiology-based classification scheme of ASDz following lumbar spine fusion. This simple classification system may allow for the grouping and standardization of patients with similar pathologies and thus for more specific pre-operative diagnoses, personalized treatments, and improved outcome analyses.
Process Parameter Impact on Suspension-HVOF-Sprayed Cr2O3 Coatings
Authors: Kiilakoski Jarkko , Trache Richard , Björklund Stefan , Joshi Shrikant , Vuoristo Petri
Published: October 2019

Chromium oxide (Cr2O3) is commonly used as an atmospheric plasma-sprayed (APS) coating from powder feedstock in applications requiring resistance to sliding wear and corrosion, as well as amenability to texturing, e.g., in anilox rolls. Recently, high-velocity oxy-fuel spray methods involving suspension feedstock have been considered an extremely promising alternative to produce denser and more homogeneous chromium oxide coatings with lower as-sprayed surface roughness, higher hardness and potentially superior wear performance compared to conventional APS-sprayed coatings. In this study, the impact of process parameters namely auxiliary air cleaning nozzles and a transverse air curtain on suspension high-velocity oxy-fuel-sprayed Cr2O3suspensions is presented. The produced coatings are characterized for their microstructure, mechanical properties and wear resistance by cavitation erosion. The results reveal the importance of optimized air nozzles and air curtain to achieve a vastly improved coating structure and performance.
Influence of Innate Sludge Factors and Ambient Environmental Parameters in Biosolids Storage on Indicator Bacteria Survival: A Review
Authors: Fane S. , Vale P. , Bajón-Fernández Y. , Cartmell E. , Nocker A. , Harris J. , Tyrrel S.
Published: October 2019

The potential health risks associated with sludge cake application to agricultural land are managed by controlling the levels of Escherichia coli (E. coli) bacteria which indicate the risk of pathogen transfer. Analyses undertaken following post-digestion sludge dewatering have shown unpredictable levels of E. coli increase in stored sludge cake. Presently there is limited understanding on environmental parameters controlling the indicator bacteria density in storage and the contributory effects dewatering may have. This review aims to establish the state of current knowledge on innate and environmental factors influencing E. coli dynamics and survival in biosolids. A key factor identified is the effect of mechanical dewatering processes, which transform the sludge matrix environmental conditions through the increased availability of growth factors (e.g. nutrient and oxygen). Examples of storage practices from the agricultural and food industries are also discussed as successful methods to inhibit bacterial growth and survival, which could be extrapolated to the biosolids sector to regulate E. coli concentrations.

Graphic Abstract
Progression and Classification of Granular Osmiophilic Material (GOM) Deposits in Functionally Characterized Human NOTCH3 Transgenic Mice
Authors: Gravesteijn Gido , Munting Leon P. , Overzier Maurice , Mulder Aat A. , Hegeman Ingrid , Derieppe Marc , Koster Abraham J. , van Duinen Sjoerd G. , Meijer Onno C. , Aartsma-Rus Annemieke , van der Weerd Louise , Jost Carolina R. , van den Maagdenberg Arn M. J. M. , Rutten Julie W. , Lesnik Oberstein Saskia A. J.
Published: October 2019

CADASIL is a NOTCH3-associated cerebral small vessel disease. A pathological ultrastructural disease hallmark is the presence of NOTCH3-protein containing deposits called granular osmiophilic material (GOM), in small arteries. How these GOM deposits develop over time and what their role is in disease progression is largely unknown. Here, we studied the progression of GOM deposits in humanized transgenic NOTCH3Arg182Cys mice, compared them to GOM deposits in patient material, and determined whether GOM deposits in mice are associated with a functional CADASIL phenotype. We found that GOM deposits are not static, but rather progress in ageing mice, both in terms of size and aspect. We devised a GOM classification system, reflecting size, morphology and electron density. Six-month-old mice showed mostly early stage GOM, whereas older mice and patient vessels showed predominantly advanced stage GOM, but also early stage GOM. Mutant mice did not develop the most severe GOM stage seen in patient material. This absence of end-stage GOM in mice was associated with an overall lack of histological vascular pathology, which may explain why the mice did not reveal functional deficits in cerebral blood flow, cognition and motor function. Taken together, our data indicate that GOM progress over time, and that new GOM deposits are continuously being formed. The GOM staging system we introduce here allows for uniform GOM deposit classification in future mouse and human studies, which may lead to more insight into a potential association between GOM stage and CADASIL disease severity, and the role of GOM in disease progression.
Nutrigenomics in livestock—recent advances
Authors: Nowacka-Woszuk Joanna
Published: October 2019

The study of the effects of nutrients on genome functioning, in terms of gene transcription, protein levels, and epigenetic mechanisms, is referred to as nutrigenomics. Nutrigenomic studies in farm animals, as distinct from rodents, are limited by the high cost of keeping livestock, their long generational distance, and ethical aspects. Yet farm animals, and particularly pigs, can serve as valuable animal models for human gastrological diseases, since they possess similar size, physiology, and nutritional habits and can develop similar pathological states. In livestock, the effects of dietary modifications have mostly been studied with reference to effective breeding and their influence on production traits and animal health. The majority of such studies have looked at the impact of various sources and quantities of fat and protein, supplementation with microelements, and plant-derived additives. The period of life of the animal—whether prenatal, neonatal, or mature—is typically considered when a modified diet is used. This review presents a summary of recent nutrigenomic studies in livestock.
Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold
Authors: Chen Jian-Li , Zhang Han , Huang Xue-Qin , Wan Hong-Ye , Li Jie , Fan Xing-Xing , Luo Kathy Qian , Wang Jinhua , Zhu Xiao-Ming , Wang Jianfang
Published: October 2019

Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region (1000–1350 nm) are strongly desired for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO2) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO2 nanostructures have a high photothermal conversion efficiency of (93.3 ± 5.2)% under 1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO2 nanostructures combined with PTT induce a synergistic antiangiogenesis effect. In vivo studies show that such CA4P-loaded NBP@TiO2 nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4 W cm−2, which is lower than the skin tolerance threshold value, exhibit a superior antitumor effect. This work presents not only the development of the NBP@TiO2 nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy.