bluuebunny/crossref_metadata_2025 huggingface dataset:
Does COVID-19 affect sperm quality in males? the answer may be yes, but only temporarily
Authors: Zhang Qi-Feng , Zhang Yu-Ji , Wang Sheng , Wei Yu , Zhang Han , Li Feng , Deng Yong-Quan
Published: January 2024

Background

The Corona Virus Disease 2019 (COVID-19) pandemic has raised concerns regarding its potential impact on male reproductive health. However, the impact of COVID-19 on sperm quality remains uncertain. This retrospective study aimed to investigate the short-term and relatively long-term effects of COVID-19 infection on sperm quality.

Methods

A total of 85 males with fertility requirements, who underwent semen evaluation at Guilin People’s Hospital between June 2022 and July 2023, were included in the study. Changes in semen parameters were analyzed across three specific timeframes: within 6 months before COVID-19 infection, within 3 months after COVID-19 infection, and 3–6 months after COVID-19 recovery.

Results

The results revealed that the sperm concentration and total sperm number were significantly lower after infection compared to before, while in the recovery period, the sperm concentration, total sperm count, progressive motility, and normal morphology significantly increased. Comparing the three periods, the most significant difference was observed in sperm concentration, which exhibited a significant decrease after infection but returned to normal levels after recovery from COVID-19.

Conclusions

These findings suggest that COVID-19 may exert some impact on sperm quality, particularly evidenced by decreased sperm concentration post-infection. Fortunately, these effects on semen parameters appear to be temporary, with gradual restoration of semen parameters within 3–6 months after recovery. However, further research is needed to explore the underlying mechanisms and long-term implications of these observed changes in semen parameters.
Steering the energy with music: hermeneutic phenomenological study of user perspectives of music and music therapy for co-occurring ADHD and substance use problems
Authors: Ghetti Claire M. , Hjelmbrekke Steinar , Morken Katharina , Dahl Therese , Stige Brynjulf
Published: January 2024

Background

User perspectives and involvement are crucial for improving substance use treatment service provision. First-hand accounts provide rich perspectives on how users experience change within therapeutic approaches like music therapy. People with substance use problems have a higher incidence of experiencing challenges with impulsivity, hyperactivity and inattention. Such challenges can negatively affect social functioning and outcomes of substance use treatment. Music therapy can offer people a means to regulate emotions and facilitate social relationships. There is a lack of research on user perspectives of music therapy in substance use treatment, and we could identify no studies that explore user perspectives of music therapy for adults with substance use problems and co-occurring impulsivity, hyperactivity and inattention.

Methods

The aim of this phenomenological study was to center the voices of people living with co-occurring attention deficit hyperactivity disorder (ADHD) and substance use disorder (SUD) to understand how they experience music and music therapy in their process of recovery. We used a hermeneutic phenomenological approach to qualitative analysis of transcripts from in-depth interviews with 8 adult service users from a Norwegian substance use treatment facility.

Results

Our main finding was that music and music therapy enabled experiences of motivation and mastery that ultimately afforded social belonging. The participants demonstrated detailed and nuanced understanding of how they use music to steer the energy and restlessness that are characteristic of ADHD, to change mood, and to shift negative thought patterns. These forms of music-centered regulation served as pre-requisites for more active and gratifying participation in social communities. For several participants, musicking offered a means of establishing drug-free identity and fellowship. The motivation and mastery experienced during musicking lowered the threshold for social engagement, and served as an incentive for continuing substance use treatment for some participants.

Conclusions

The nuanced descriptions from our participants illustrate the importance of motivation, and how music therapy can contribute to motivation in substance use treatment. In particular, the context surrounding musicking, adaptations from the music therapist, and social affordances of such musicking contributed to pleasure, mastery, participation, development of identity and social belonging, which in interaction generated motivation.
Augmenting MEK inhibitor efficacy in BRAF wild-type melanoma: synergistic effects of disulfiram combination therapy
Authors: Meraz-Torres Francisco , Niessner Heike , Plöger Sarah , Riel Simon , Schörg Barbara , Casadei Nicolas , Kneilling Manfred , Schaller Martin , Flatz Lukas , Macek Boris , Eigentler Thomas , Rieß Olaf , Garbe Claus , Amaral Teresa , Sinnberg Tobias
Published: January 2024

Background

MEK inhibitors (MEKi) were shown to be clinically insufficiently effective in patients suffering from BRAF wild-type (BRAF WT) melanoma, even if the MAPK pathway was constitutively activated due to mutations in NRAS or NF-1. Thus, novel combinations are needed to increase the efficacy and duration of response to MEKi in BRAF WT melanoma. Disulfiram and its metabolite diethyldithiocarbamate are known to have antitumor effects related to cellular stress, and induction of endoplasmic reticulum (ER) stress was found to synergize with MEK inhibitors in NRAS-mutated melanoma cells. Therefore, we investigated the combination of both therapeutics to test their effects on BRAF-WT melanoma cells and compared them with monotherapy using the MEKi trametinib.

Methods

The effects of combined therapy with disulfiram or its metabolite diethyldithiocarbamate and the MEKi trametinib were evaluated in a series of BRAF-WT melanoma cell lines by measuring cell viability and apoptosis induction. Cytotoxicity was additionally assessed in 3D spheroids, ex vivo melanoma slice cultures, and in vivo xenograft mouse models. The response of melanoma cells to treatment was studied at the RNA and protein levels to decipher the mode of action. Intracellular and intratumoral copper measurements were performed to investigate the role of copper ions in the antitumor cytotoxicity of disulfiram and its combination with the MEKi.

Results

Diethyldithiocarbamate enhanced trametinib-induced cytotoxicity and apoptosis induction in 2D and 3D melanoma culture models. Mechanistically, copper-dependent induction of oxidative stress and ER stress led to Janus kinase (JNK)-mediated apoptosis in melanoma cells. This mechanism was also detectable in patient-derived xenograft melanoma models and resulted in a significantly improved therapeutic effect compared to monotherapy with the MEKi trametinib.

Conclusions

Disulfiram and its metabolite represent an attractive pharmaceutical approach to induce ER stress in melanoma cells that potentiates the antitumor effect of MEK inhibition and may be an interesting candidate for combination therapy of BRAF WT melanoma.
Exploring the causal role of multiple metabolites on ovarian cancer: a two sample Mendelian randomization study
Authors: Liu Shaoxuan , Ding Danni , Liu Fangyuan , Guo Ying , Xie Liangzhen , Han Feng-Juan
Published: January 2024

Background

The mechanisms and risk factors underlying ovarian cancer (OC) remain under investigation, making the identification of new prognostic biomarkers and improved predictive factors critically important. Recently, circulating metabolites have shown potential in predicting survival outcomes and may be associated with the pathogenesis of OC. However, research into their genetic determinants is limited, and there are some inadequacies in understanding the distinct subtypes of OC. In this context, we conducted a Mendelian randomization study aiming to provide evidence for the relationship between genetically determined metabolites (GDMs) and the risk of OC and its subtypes.

Methods

In this study, we consolidated genetic statistical data of GDMs with OC and its subtypes through a genome-wide association study (GWAS) and conducted a two-sample Mendelian randomization (MR) analysis. The inverse variance weighted (IVW) method served as the primary approach, with MR-Egger and weighted median methods employed for cross-validation to determine whether a causal relationship exists between the metabolites and OC risk. Moreover, a range of sensitivity analyses were conducted to validate the robustness of the results. MR-Egger intercept, and Cochran’s Q statistical analysis were used to evaluate possible heterogeneity and pleiotropy. False discovery rate (FDR) correction was applied to validate the findings. We also conducted a reverse MR analysis to validate whether the observed blood metabolite levels were influenced by OC risk. Additionally, metabolic pathway analysis was carried out using the MetaboAnalyst 5.0 software.

Results

In MR analysis, we discovered 18 suggestive causal associations involving 14 known metabolites, 8 metabolites as potential risk factors, and 6 as potential cancer risk reducers. In addition, three significant pathways, "caffeine metabolism," "arginine biosynthesis," and "citrate cycle (TCA cycle)" were associated with the development of mucinous ovarian cancer (MOC). The pathways "caffeine metabolism" and "alpha-linolenic acid metabolism" were associated with the onset of endometrioid ovarian cancer (OCED).

Conclusions

Our MR analysis revealed both protective and risk-associated metabolites, providing insights into the potential causal relationships between GDMs and the metabolic pathways related to OC and its subtypes. The metabolites that drive OC could be potential candidates for biomarkers.
Comparison of lung ultrasound and chest radiography for detecting pneumonia in children: a systematic review and meta-analysis
Authors: Yang Yalong , Wu Yuexuan , Zhao Wen
Published: January 2024

Background

Lung ultrasound (LUS) is recommended as a reliable diagnostic alternative to chest X-ray (CXR) for detecting pneumonia in children.

Methods

PubMed, Embase, and Cochrane Library databases were used to identify eligible studies from their inception until April 2023. The investigated diagnostic parameters included sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curves (AUC).

Results

Twenty-six studies involving 3,401 children were selected for meta-analysis. The sensitivity, specificity, PLR, NLR, DOR, and AUC of LUS for detecting pneumonia in children were 0.95, 0.92, 12.31, 0.05, 108.53, and 0.98, respectively, while the sensitivity, specificity, PLR, NLR, DOR, and AUC of CXR were 0.92, 0.93, 24.63, 0.08, 488.54, and 0.99, respectively. The sensitivity of LUS was higher than that of CXR for detecting pneumonia in children (ratio: 1.03; 95% CI: 1.01–1.06; P = 0.018), whereas the DOR of LUS was significantly lower than that of CXR (ratio: 0.22; 95% CI: 0.06–0.85; P = 0.028).

Conclusions

This study found that the diagnostic performance of LUS was comparable to that of CXR for detecting pneumonia, and the sensitivity of LUS was superior to that of CXR.
Gastrointestinal bleeding in children: diagnostic approach
Authors: Piccirillo Marisa , Pucinischi Valentina , Mennini Maurizio , Strisciuglio Caterina , Iannicelli Elsa , Giallorenzi Maria Agostina , Furio Silvia , Ferretti Alessandro , Parisi Pasquale , Di Nardo Giovanni
Published: January 2024

Different conditions may underlie gastrointestinal bleeding (GIB) in children. The estimated prevalence of GIB in children is 6.4%, with spontaneous resolution in approximately 80% of cases. Nonetheless, the initial approach plays a pivotal role in determining the prognosis. The priority is the stabilization of hemodynamic status, followed by a systematic diagnostic approach. GIB can originate from either upper or lower gastrointestinal tract, leading to a broad differential diagnosis in infants and children. This includes benign and self-limiting disorders, alongside serious conditions necessitating immediate treatment. We performed a nonsystematic review of the literature, in order to describe the variety of conditions responsible for GIB in pediatric patients and to outline diagnostic pathways according to patients’ age, suspected site of bleeding and type of bleeding which can help pediatricians in clinical practice. Diagnostic modalities may include esophagogastroduodenoscopy and colonoscopy, abdominal ultrasonography or computed tomography and, when necessary, magnetic resonance imaging. In this review, we critically assess these procedures, emphasizing their respective advantages and limitations concerning specific clinical scenarios.
Time in ICU and post-intensive care syndrome: how long is long enough?
Authors: Flaws Dylan , Fraser John F. , Laupland Kevin , Lavana Jayshree , Patterson Sue , Tabah Alexis , Tronstad Oystein , Ramanan Mahesh
Published: January 2024

Background

Our understanding of post-ICU recovery is influenced by which patients are selected to study and treat. Many studies currently list an ICU length of stay of at least 24, 48, or 72 h as an inclusion criterion. This may be driven by established evidence that prolonged time in an ICU bed and prolonged ventilation can complicate post-ICU rehabilitation. However, recovery after short ICU stays still needs to be explored.

Methods

This is a secondary analysis from the tracking outcomes post-intensive care (TOPIC) study. One hundred and thirty-two participants were assessed 6-months post-ICU discharge using standardised and validated self-report tools for physical function, cognitive function, anxiety, depression and post-traumatic stress disorder (with clinically significant impairment on any tool being considered a complicated recovery). Routinely collected data relating to the ICU stay were retrospectively accessed, including length of stay and duration of mechanical ventilation. Patients with short ICU stays were intentionally included, with 77 (58%) participants having an ICU length of stay < 72 h.

Results

Of 132 participants, 40 (30%) had at least one identified post-ICU impairment 6 months after leaving ICU, 22 (17%) of whom had an ICU length of stay < 72 h.

Conclusion

Many patients with an ICU length of stay < 72 h are reporting post-ICU impairment 6 months after leaving ICU. This is a population often excluded from studies and interventions. Future research should further explore post-ICU impairment among shorter stays.
Blood proteins self-assembly, staphylococcal enterotoxins-interaction, antibacterial synergistic activities of biogenic carbon/FeSO4/Cu/CuO nanocomposites modified with three antibiotics
Authors: Alavi Mehran , Karimi Nasser
Published: January 2024

Introduction

Nanocomposites based on copper, iron, and carbon materials are novel nanomaterials with both antibacterial and biocompatibility properties considerable to fight against multidrug-resistant bacteria.

Methods

In this study, phytogenic carbon/FeSO4/Cu/CuO nanocomposites modified by three antibiotics including tetracycline, amoxicillin, and penicillin were employed to hinder antibiotic resistant bacteria of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Interaction of albumin and hemoglobin as major blood proteins with these nanocomposites were evaluated by SEM, FTIR, and AFM techniques. As in silico study, molecular docking properties of staphylococcal enterotoxin toxin A and B with (Z)-α-Bisabolene epoxide, (E)-Nerolidol, α-Cyperone, daphnauranol C, nootkatin, and nootkatone as major secondary metabolites of Daphne mucronata were obtained by AutoDock Vina program.

Results

Physicochemical characterization of nanocomposites showed (Zeta potential (− 5.09 mV), Z-average (460.2 d.nm), polydispersity index (0.293), and size range of 44.58 ± 6.78 nm). Results of both in vitro and in silico surveys disclosed significant antibacterial activity of antibiotic functionalized carbon/FeSO4/Cu/CuO nanocomposites compared to antibiotics alone towards Gram-negative and Gram-positive bacteria.

Conclusion

Synergistic activity of bio-fabricated carbon/FeSO4/Cu/CuO nanocomposites with antibiotics may be affected by main parameters of concentration and ratio of antibacterial agents, physicochemical properties of nanocomposites, bacterial type (Gram-negative or Gram-positive), antibacterial mechanisms, and chemical structure of antibiotics.
Wisconsin diversity panel phenotypes: spoken descriptions of plants and supporting data
Authors: Yanarella Colleen F. , Fattel Leila , Kristmundsdóttir Ásrún Ý. , Lopez Miriam D. , Edwards Jode W. , Campbell Darwin A. , Abel Craig A. , Lawrence-Dill Carolyn J.
Published: January 2024

Objectives

Phenotyping plants in a field environment can involve a variety of methods including the use of automated instruments and labor-intensive manual measurement and scoring. Researchers also collect language-based phenotypic descriptions and use controlled vocabularies and structures such as ontologies to enable computation on descriptive phenotype data, including methods to determine phenotypic similarities. In this study, spoken descriptions of plants were collected and observers were instructed to use their own vocabulary to describe plant features that were present and visible. Further, these plants were measured and scored manually as part of a larger study to investigate whether spoken plant descriptions can be used to recover known biological phenomena.

Data description

Data comprise phenotypic observations of 686 accessions of the maize Wisconsin Diversity panel, and 25 positive control accessions that carry visible, dramatic phenotypes. The data include the list of accessions planted, field layout, data collection procedures, student participants’ (whose personal data are protected for ethical reasons) and volunteers’ observation transcripts, volunteers’ audio data files, terrestrial and aerial images of the plants, Amazon Web Services method selection experimental data, and manually collected phenotypes (e.g., plant height, ear and tassel features, etc.; measurements and scores). Data were collected during the summer of 2021 at Iowa State University’s Agricultural Engineering and Agronomy Research Farms.
Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder
Authors: Wilkes Bradley J. , Archer Derek B. , Farmer Anna L. , Bass Carly , Korah Hannah , Vaillancourt David E. , Lewis Mark H.
Published: January 2024

Background

Restricted repetitive behavior (RRB) is one of two behavioral domains required for the diagnosis of autism spectrum disorder (ASD). Neuroimaging is widely used to study brain alterations associated with ASD and the domain of social and communication deficits, but there has been less work regarding brain alterations linked to RRB.

Methods

We utilized neuroimaging data from the National Institute of Mental Health Data Archive to assess basal ganglia and cerebellum structure in a cohort of children and adolescents with ASD compared to typically developing (TD) controls. We evaluated regional gray matter volumes from T1-weighted anatomical scans and assessed diffusion-weighted scans to quantify white matter microstructure with free-water imaging. We also investigated the interaction of biological sex and ASD diagnosis on these measures, and their correlation with clinical scales of RRB.

Results

Individuals with ASD had significantly lower free-water corrected fractional anisotropy (FAT) and higher free-water (FW) in cortico-basal ganglia white matter tracts. These microstructural differences did not interact with biological sex. Moreover, both FATand FW in basal ganglia white matter tracts significantly correlated with measures of RRB. In contrast, we found no significant difference in basal ganglia or cerebellar gray matter volumes.

Limitations

The basal ganglia and cerebellar regions in this study were selected due to their hypothesized relevance to RRB. Differences between ASD and TD individuals that may occur outside the basal ganglia and cerebellum, and their potential relationship to RRB, were not evaluated.

Conclusions

These new findings demonstrate that cortico-basal ganglia white matter microstructure is altered in ASD and linked to RRB. FW in cortico-basal ganglia and intra-basal ganglia white matter was more sensitive to group differences in ASD, whereas cortico-basal ganglia FATwas more closely linked to RRB. In contrast, basal ganglia and cerebellar volumes did not differ in ASD. There was no interaction between ASD diagnosis and sex-related differences in brain structure. Future diffusion imaging investigations in ASD may benefit from free-water estimation and correction in order to better understand how white matter is affected in ASD, and how such measures are linked to RRB.
Effect of fuel injection pressure on the performances of a CI engine using water-emulsified diesel (WED) as a fuel
Authors: Mondal Pijush Kanti , Mandal Bijan Kumar
Published: January 2024

Background

The choice of energy sources is essential for sustainable development to combat different environmental issues caused by the consumption of fossil fuels. Though diesel engines are considered more efficient and reliable than other internal combustion engines, they emit different harmful pollutants which are detrimental to human health and the environment. Researchers are trying to find suitable alternative fuels for diesel engines with lower pollutant emissions and without much compromise in the efficiency of the engine. In this regard, water-emulsified diesel (WED) may be considered to be one of the most suitable alternative fuels. It is expected that the entire world will use electric vehicles in the long term. However, the complete replacement of IC engines in the near future is not feasible. In fact, different European countries have targeted to ban the use of diesel engine cars before the middle of the twenty-first century. Prior to that date, hybrid vehicles will be more popular and diesel engines will continue to play an important role. Hence, research involving improvements in diesel-operated IC engines is still relevant.

Methods

An experimental investigation was carried out using WED containing 10% water by volume as a fuel in a diesel engine at four different fuel injection pressures. The WED was prepared using an ultrasonicator.

Results

With the increase of injection pressure, peak net heat release rate and in-cylinder pressure are found to have increased. Brake thermal efficiency is also found to have improved at higher injection pressure. The maximum efficiency was recorded when a WED at 210 bar of injection pressure is used, and it is about 3.3% higher than the maximum efficiency achieved when using normal diesel at the same pressure of fuel injection. At a higher load, neat brake-specific fuel consumption is found to be less compared to neat diesel, when only the amount of diesel contained in the emulsion as a fuel is considered. Maximum reduction in both NOx and smoke emission by using WED is recorded at 210 bar, and the average reductions are determined to be 32.6% and 51.9%, respectively.

Conclusions

WED can be used as an alternative fuel for existing diesel engines without any retrofitting and with significant reduction in the emissions of pollutants compared to normal diesel fuel. It can also be concluded that at higher injection pressure, the combustion, performance and emission characteristics of compression ignition engines are improved when using emulsified diesel.
Barriers, facilitators, perceptions and impact of interventions in implementing antimicrobial stewardship programs in hospitals of low-middle and middle countries: a scoping review
Authors: Harun Md. Golam Dostogir , Sumon Shariful Amin , Hasan Istiaque , Akther Fairoze Masuda , Islam Md. Saiful , Anwar Md. Mahabub Ul
Published: January 2024

Background

Antimicrobial stewardship programs (ASPs) are pivotal components of the World Health Organization's Global Action Plan to combat antimicrobial resistance (AMR). ASPs advocate rational antibiotic usage to enhance patient-centered outcomes. However, existing evidence on ASPs and their determinants is largely limited to well-equipped hospitals in high-income nations.

Objective

This scoping review aimed to examine the current state of hospital-based ASPs in low- and middle-income countries (LMICs), shedding light on barriers, facilitators, prescribers’ perceptions and practices, and the impact of ASP interventions.

Design

Scoping review on ASP.

Methods

Adhering to PRISMA guidelines, we conducted electronic database searches on PubMed, Scopus, and Google Scholar, covering ASP articles published between January 2015 and October 2023. Our review focused on four key domains: barriers to ASP implementation, facilitators for establishing ASP, ASP perceptions and practices of prescribers, and the impact of ASP interventions. Three reviewers separately retrieved relevant data from the included citations using EndNote 21.0.

Results

Among the 7016 articles searched, 84 met the inclusion criteria, representing 34 LMICs. Notably, 58% (49/84) of these studies were published after 2020. Barriers to ASP implementation, including human-resources shortage, lack of microbiology laboratory support, absence of leadership, and limited governmental support, were reported by 26% (22/84) of the studies. Facilitators for hospital ASP implementation identified in five publications included the availability of antibiotic guidelines, ASP protocol, dedicated multidisciplinary ASP committee, and prompt laboratory support. The majority of the research (63%, 53/84) explored the impacts of ASP intervention on clinical, microbiological, and economic aspects. Key outcomes included increased antibiotic prescription appropriateness, reduced antimicrobial consumption, shorter hospital stays, decreased mortality rate, and reduced antibiotic therapy cost.

Conclusions

The published data underscores the imperative need for widespread antimicrobial stewardship in LMIC hospital settings. Substantial ASP success can be achieved through increasing human resources, context-specific interventions, the development of accessible antibiotic usage guidelines, and heightened awareness via training and education.
Evaluating density-weighted connectivity of black bears (Ursus americanus) in Glacier National Park with spatial capture–recapture models
Authors: Carroll Sarah L. , Schmidt Greta M. , Waller John S. , Graves Tabitha A.
Published: January 2024

Background

Improved understanding of wildlife population connectivity among protected area networks can support effective planning for the persistence of wildlife populations in the face of land use and climate change. Common approaches to estimating connectivity often rely on small samples of individuals without considering the spatial structure of populations, leading to limited understanding of how individual movement links to demography and population connectivity. Recently developed spatial capture-recapture (SCR) models provide a framework to formally connect inference about individual movement, connectivity, and population density, but few studies have applied this approach to empirical data to support connectivity planning.

Methods

We used mark-recapture data collected from 924 genetic detections of 598 American black bears (Ursus americanus) in 2004 with SCR ecological distance models to simultaneously estimate density, landscape resistance to movement, and population connectivity in Glacier National Park northwest Montana, USA. We estimated density and movement parameters separately for males and females and used model estimates to calculate predicted density-weighted connectivity surfaces.

Results

Model results indicated that landscape structure influences black bear density and space use in Glacier. The mean density estimate was 16.08 bears/100 km2 (95% CI 12.52–20.6) for females and 9.27 bears/100 km2 (95% CI 7.70–11.14) for males. Density increased with forest cover for both sexes. For male black bears, density decreased at higher grizzly bear (Ursus arctos) densities. Drainages, valley bottoms, and riparian vegetation decreased estimates of landscape resistance to movement for male and female bears. For males, forest cover also decreased estimated resistance to movement, but a transportation corridor bisecting the study area strongly increased resistance to movement presenting a barrier to connectivity.

Conclusions

Density-weighed connectivity surfaces highlighted areas important for population connectivity that were distinct from areas with high potential connectivity. For black bears in Glacier and surrounding landscapes, consideration of both vegetation and valley topography could inform the placement of underpasses along the transportation corridor in areas characterized by both high population density and potential connectivity. Our study demonstrates that the SCR ecological distance model can provide biologically realistic, spatially explicit predictions to support movement connectivity planning across large landscapes.
Perceptions of the importance of sports nutrition knowledge and barriers in implementing them: a qualitative study among track and field stakeholders in Sri Lanka
Authors: Jayawardena Ranil , Weerasinghe Kalani , Madhujith Terrence , Hills Andrew P. , Kalupahana Nishan
Published: January 2024

Background

Integrating the core aspects of sports nutrition knowledge [SNK] into the multidisciplinary team is critical to improving an athlete’s performance and well-being. Conducting in-depth interviews with members of the sports-related team is a comprehensive method of gathering information on various aspects of SNK. This qualitative study aimed to examine the opinions and beliefs of stakeholders in athletics regarding the importance of SNK.

Methods

Fifteen professional track and field athletes and stakeholders were recruited into the study. Separate in-depth interviews were conducted to collect information within four key themes. Practical difficulties in getting an appropriate meal were included in an additional theme. Thematic analysis was performed using NVIVO v10.0.

Results

All participants were mindful of the importance of proper food habits for overall athletic outcomes and reported different opinions on meal timing and composition. The opinions on supplements were heterogeneous and both positive and negative claims were reported. Beliefs regarding hydration demonstrated that the cohort was well aware of the significance of adequate hydration plus the signs and consequences of dehydration with many reporting experiences of the negative consequences of dehydration. All respondents reported that both alcohol and smoking may have an adverse impact on performance and health.

Conclusions

All respondents emphasized the importance of proper food habits for sports performance and well-being, but also identified barriers to optimizing nutrition.
Enhancing quality of life and medication adherence for people living with HIV: the impact of an information system
Authors: Panayi Maria , Charalambous Georgios K. , Jelastopulu Eleni
Published: January 2024

Background

The widespread availability of antiretroviral therapy has led to improvements in life expectancy and thus an increase in the number of people living with HIV/AIDS (PLWHA) worldwide. However, a similar increase in the number of newly-diagnosed patients in Cyprus suggests the need for solutions designed to improve monitoring, planning, and patient communication. In this study, we aimed to determine whether the use of an information system to manage PLWHA might contribute to improved quality of life and critical adherence to prescribed drug regimens and ongoing medical care.

Methods

A randomized controlled trial study was conducted in Cyprus based on information that we collected using the highly valid and reliable Greek translation of the World Health Organization (WHO) Quality of Life (QOL) HIV-BREF questionnaire to assess sociodemographic variables and patient compliance. We distributed 200 questionnaires before implementing a Health Medical Care (HMC) information system at our clinic. Six months after implementing this system, 68 of the completed questionnaires were selected, including two groups of 34 participants who had been assigned at random to the intervention or the control group. Participants included PLWHA aged ≥ 18 years who had been receiving antiretroviral therapy for more than 12 months between July 15, 2020, and July 15, 2022.

Results

The changes in baseline to six-month scores reported for the intervention group were significantly higher than in the control group in all six subscales assessed with the WHOQOL-HIV-BREF questionnaire, as well as in the assessment of compliance. Furthermore, compliance with treatment was associated with higher scores in the questionnaire subscales, including physical health, psychological health, degree of autonomy, social relationships, life circumstances, and spirituality/religious/personal beliefs. We also identified specific demographic factors and behaviors that were associated with better compliance with scheduled medical care and the prescribed drug regimen. Specifically, men exhibited better compliance than women and younger PLWHA exhibited better compliance than the elderly as did individuals who reported a higher level of educational attainment. Additionally, individuals who did not use addictive substances, consumed less alcohol, and were managed using the monitoring information system all exhibited better compliance compared to those in the control group.

Conclusion

The results of this study suggest that management of PLWHA via the use of an information system can contribute to improved QOL and drug compliance.
Spectrum of imaging findings in osteoarticular tuberculosis
Authors: Jangid Ravina , Solanki R. S. , Chaudhary Vikas , Sud Alok , Kaur Ravinder
Published: January 2024

Background

Tuberculosis (TB) is still a major public health problem. It is endemic in most of the developing countries. Osteoarticular tuberculosis is an uncommon infection, and its diagnosis is often missed due to non-specific clinical and imaging findings.

Main body of abstract

The diagnosis of osteoarticular TB is often delayed due to non-specific clinical presentation and often mimics with other infectious/inflammatory disorders. However, as the disease is curable, prompt diagnosis and early initiation of treatment remain critical to prevent the development of deformity and bone destruction. MRI is sensitive in early detection of articular and marrow abnormalities, detecting complications and assessing response to treatment.

In this review, we describe the spectrum of various MR imaging findings of osteoarticular TB, which helps in early diagnosis and differentiating these from other pathologies with similar imaging appearances. These are described through case-based illustrations of different anatomical locations of osteoarticular TB.

Short conclusion

MR imaging is the emerging modality of choice for early diagnosis of osteoarticular tuberculosis and helps to differentiate it from other infective/inflammatory diseases.
Ultrasound-guided percutaneous nephrolithotomy versus conventional c-arm-guided percutaneous nephrolithotomy: a prospective randomized comparative study
Authors: Elmarakbi Akram A. , Gaber Mohamed Ahmed M. , Massoud Amr M. , Abdelbary Ahmed , Ibrahim Rabie M.
Published: January 2024

Background

Ultrasound guidance for renal access in percutaneous nephrolithotomy (PCNL) is a safe, effective, and low-cost procedure. The current study compared the safety and effectiveness of ultrasound-guided PCNL (US-PCNL) for renal stone therapy versus fluoroscopy-guided PCNL (FL-PCNL) in prone position.

Results

Successful puncture was attained in all cases in both groups. Unlike fluoroscopy, US guidance reduced the time needed for achieving renal puncture that was (22.45 ± 6.95 s) compared to fluoroscopy that was (68.28 ± 56.76 s) (Pvalue < 0.001). The mean duration of access that was reported in our study was (3.92 ± 0.72 min) in the US-PCNL group and (4.03 ± 0.77 min) in the FL-PCNL group (Pvalue 0.460). There was no significant difference in the total operative time between both groups in our study as the mean operative time in the US-PCNL group was (61.47 ± 6.07 min) and (65.86 ± 20.86 min) in the FL-PCNL group with a (Pvalue of 0.349). Stone-free rate was nearly similar in both groups (Pvalue 0.336). Three cases in our study in the FL-PCNL group had bleeding that required blood transfusion post-operative; mean Hb change was 0.23 g/dL and 0.55 g/dL in US-PCNL and FL-PCNL groups, respectively, which is clinically irrelevant despite statistical significance (Pvalue 0.007). Mean fluoroscopy time was (6.38 ± 3.84) minutes in FL-PCNL group.

Conclusion

Ultrasound guidance is a reliable tool in the hands of experienced urologists in performing PCNL with less or even zero radiation.
Optimum stimulus for eliciting masseter vestibular-evoked myogenic potential: a comparative exploration with three different acoustic stimuli
Authors: Nagarajan Aishwarya , Thirusangu Vinayagar Pazhani , Mohanlal Gunasekaran , Sinha Sujeet Kumar
Published: January 2024

Objective

To compare the EMG rectified amplitude, absolute latencies, interpeak interval, and Interaural asymmetry parameters of masseter vestibular-evoked myogenic potential (mVEMP) elicited using clicks, 500 Hz tone bursts, and 500 Hz NB CE-chirps.

Method

Twenty-five young healthy adults in the age range of 18–27 years participated for the study. mVEMP was recorded using three different acoustic stimuli i.e., clicks, 500 Hz tone bursts, and 500 Hz NB CE-chirps. mVEMP was recorded at an intensity of 125 dB peSPL with 5.1/s repetition rate. The potentials were recorded ipsilaterally using zygomatic electrode montage and were filtered between 0.1 and 3000 Hz. EMG rectification of the responses was made prior to analysis.

Results

The latencies of P1 and N1 were significantly earlier for chirps then followed by click and tone bursts. The EMG rectified amplitude was significantly larger for the potentials obtained using chirps followed by tone bursts and then the clicks. Masseter VEMP obtained using chirps had significantly larger interpeak interval than tone bursts and clicks. The mean amplitude asymmetry ratio was greater in the potentials obtained using chirps than the other two stimuli.

Conclusion

The present study reveals that 500 Hz NB CE-chirps tend to produce mVEMP with larger response amplitude and earlier latencies and thus are considered better and constructive stimuli compared to clicks and tone bursts.
Looking at the cultural heritage proclamations of Ethiopia: conceptualisation and management of cultural heritage
Authors: Zewdu Mengistie
Published: January 2024

The main purpose of this paper is to explore how the conceptualisation and management of cultural heritage have been treated in the cultural heritage proclamations of Ethiopia. The analysis of the four cultural heritage proclamations reveals that the notion of cultural heritage improves from the first to the fourth proclamation. In the first two proclamations, the term antiquity was employed, and the latter two employed the term of cultural heritage. The 1966 proclamation included antiquities that were dated prior to 1850 EC, while the 1989 proclamation removed this cutoff date and expounded upon the definition of antiquities. The 2000 proclamation replaced the term antiquity with cultural heritage and introduced the concept of intangible cultural heritage. In terms of the management of cultural heritage, the differences between the 1989 and 2000 proclamations are quite minimal. The 2014 proclamation attempted to classify cultural heritage into national and regional cultural heritage. It also defined important components of intangible cultural heritage. The management of cultural heritage exhibits some evolution from the first to the last proclamation. However, due to the diversified nature of cultural heritage conceptualisation and management, it will be important for additional legislation to be issued separately for movable, immovable and intangible cultural heritage, for example. This study argues that strong legal and institutional frameworks should be established to properly protect, conserve and study cultural heritage.
Update on vitamin D role in severe infections and sepsis
Authors: Cutuli Salvatore Lucio , Ferrando Elena Sancho , Cammarota Fabiola , Franchini Emanuele , Caroli Alessandro , Lombardi Gianmarco , Tanzarella Eloisa Sofia , Grieco Domenico Luca , Antonelli Massimo , De Pascale Gennaro
Published: January 2024

Severe infections frequently require admission to the intensive care unit and cause life-threatening complications in critically ill patients. In this setting, severe infections are acknowledged as prerequisites for the development of sepsis, whose pathophysiology implies a dysregulated host response to pathogens, leading to disability and mortality worldwide.

Vitamin D is a secosteroid hormone that plays a pivotal role to maintain immune system homeostasis, which is of paramount importance to resolve infection and modulate the burden of sepsis. Specifically, vitamin D deficiency has been widely reported in critically ill patients and represents a risk factor for the development of severe infections, sepsis and worse clinical outcomes. Several studies have demonstrated the feasibility, safety and effectiveness of vitamin D supplementation strategies to improve vitamin D body content, but conflictual results support its benefit in general populations of critically ill patients. In contrast, small randomised clinical trials reported that vitamin D supplementation may improve host-defence to pathogen invasion via the production of cathelicidin and specific cytokines. Nonetheless, no large scale investigations have been designed to specifically assess the impact of vitamin D supplementation on the outcome of critically ill septic patients admitted to the intensive care unit.
Wireless Interrogation During Cardiac Surgery For a Patient With Aveir Leadless Pacemaker: A Case Report
Authors: Kida Tatsuya , Kobashi Teisei , Makita Satoru , Sumitomo Masakazu
Published: January 2024

Intraoperative wireless interrogation is a useful monitoring method for the leadless pacemaker (LP); however, there are few reports on this technique. A 60-year-old woman underwent cardiac surgery 24 days after Aveir LP implantation. Considering the risk of intraoperative device dislodgment and pacemaker malfunction due to electromagnetic interference, the LP was monitored by wireless interrogation via body-surface electrodes, and no device dislodgement or pacemaker malfunction was observed during surgery. Our findings suggest that wireless interrogation using body-surface electrodes on the chest is a practical and valuable monitoring technique in open-heart surgery, which lends additional safety to anesthetic management.
Oceaning
Authors: Fish Adam
Published: January 2024

Drones are revolutionizing ocean conservation. By flying closer and seeing more, drones enhance intimate contact between ocean scientists and activists and marine life. In the process, new dependencies between nature, technology, and humans emerge, and a paradox becomes apparent: Can we have a wild ocean whose survival is reliant upon technology? In Oceaning, Adam Fish answers this question through eight stories of piloting drones to stop the killing of porpoises, sharks, and seabirds and to check the vitality of whales, seals, turtles, and coral reefs. Drone conservation is not the end of nature. Instead, drone conservation results in an ocean whose flourishing both depends upon and escapes the control of technologies. Faulty technology, oceanic and atmospheric turbulence, political corruption, and the inadequacies of basic science serve to foil governance over nature. Fish contends that what emerges is an ocean/culture—a flourishing ocean that is distinct from but exists alongside humanity.
Evaluating community-wide temporal sampling in passive acoustic monitoring: A comprehensive study of avian vocal patterns in subtropical montane forests
Authors: Wu Shih-Hung , Ko Jerome Chie-Jen , Lin Ruey-Shing , Chang-Yang Chia-Hao , Chang Hsueh-Wen
Published: January 2024

Background From passive acoustic monitoring (PAM) recordings, the vocal activity rate (VAR), vocalizations per unit of time, can be calculated and is essential for assessing bird population abundance. However, VAR is subject to influences from a range of factors, including species and environmental conditions. Identifying the optimal sampling design to obtain representative acoustic data for VAR estimation is crucial for research objectives. PAM commonly uses temporal sampling strategies to decrease the volume of recordings and the resources needed for audio data management. Yet, the comprehensive impact of this sampling approach on VAR estimation remains insufficiently explored. Methods In this study, we used vocalizations extracted from recordings of 12 bird species, taken at 14 PAM stations situated in subtropical montane forests over a four-month period, to assess the impact of temporal sampling on VAR across three distinct scales: short-term periodic, diel, and hourly. For short-term periodic sampling analysis, we employed hierarchical clustering analysis (HCA) and the coefficient of variation (CV). Generalized additive models (GAMs) were utilized for diel sampling analysis, and we determined the average difference in VAR values per minute for the hourly sampling analysis. Results We identified significant day and species-specific VAR fluctuations. The survey season was divided into five segments; the earliest two showed high variability and are best avoided for surveys. Data from days with heavy rain and strong winds showed reduced VAR values and should be excluded from analysis. Continuous recordings spanning at least seven days, extending to 14 days is optimal for minimizing sampling variance. Morning chorus recordings effectively capture the majority of bird vocalizations, and hourly sampling with frequent, shorter intervals aligns closely with continuous recording outcomes. Conclusions While our findings are context-specific, they highlight the significance of strategic sampling in avian monitoring, optimizing resource utilization and enhancing the breadth of monitoring efforts.
ZF-Class Nominalism and the Küng-Armstrong Trilemma
Authors: Calemi Francesco
Published: January 2024

This paper will examine the Küng-Armstrong trilemma against Class Nominalism. We will see that combining Class Nominalism and Zermelo-Fraenkel set theory (ZF) can provide us with a sophisticated version of Class Nominalism, namely ZF-Class Nominalism, which successfully addresses the objection and leads to a moderate version of ineffabilism about the putative set-membership relation.
La dialéctica Realidad/Verdad en las Notas sobre el cinematógrafo de Robert Bresson.
Authors: Hoyos Morales Alfonso
Published: January 2024

El presente texto procura esclarecer la noción de verdad en las Notas sobre el cinematógrafo de Robert Bresson. El análisis nos llevará a establecer una separación entre los conceptos de “realidad” y “verdad”, a pesar de estar vinculados. La noción de “realidad” estará conectada, fundamentalmente, a la noción de la indexicalidad. La “verdad” consistirá, por otro lado, en la apertura o posibilidad del sentido de eso “real” que no se ofrece. Esta tensión entre “verdad” y “realidad” integra, en sí mismo otras dos dialécticas: entre la inmanencia y la trascendencia y entre la actividad y la pasividad de eso “real”.