bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical behavior and electrical conductivity of ferromagnetic nanostructured Co:Fe thin films
Authors: Abbas Qayes A.
Published: August 2023

Recently, there has been an increasing interest in optical applications of nanostructured metal thin films based on transparent conductive layers. There is little data published on the study of the optical behavior of ferromagnetic materials such as Co:Fe alloy thin films. DC sputtering technique was used to grow the magnetic crystalline Co:Fe thin films, on glass substrates, in different nano-thicknesses in range of 20, 35, 50, 75 and 100[Formula: see text]nm. XRD technique, atomic force microscopy (AFM), and a spectrophotometer of Ultraviolet–visible (UV–Vis) were used to analyze the films. The XRD data confirmed that the samples of Co:Fe films showed out-of-plane direction of [Formula: see text]. The data indicates that an increase in the average grain size and lattice constant of the films is presented related to increase in the nano-thickness of Co:Fe alloy thin films samples. From AFM, it is illustrated that the roughness of the film is about ([Formula: see text][Formula: see text]nm) which is due to the produced grains. The optical response, optical conductivity and electrical conductivity have been affected by the changed nano-thickness of the metallic Co:Fe thin films.
The Current Situation, Development, and Prospects of the Iron and Steel Industry in the Process towards the “Dual Carbon” Goals
Authors: WEI Wei , ZHOU Dianmin , CHEN Zhaohui
Published: August 2023

The iron and steel industry is the largest carbon emitter in China’s manufacturing sector and one of the most important fields in the country’s response to climate change. This paper aims to explain the current situation, technological pathways, and future direction of green and low-carbon development of the iron and steel industry. According to the carbon emissions of the iron and steel industry, this paper analyzes the relationship between steelmaking technologies and carbon emissions, as well as the transformation trend of the world’s iron and steel industry, finding that China’s iron and steel industry faces both opportunities and challenges. Steel scrap recycling and electric furnace steelmaking technologies, re-electrification, hydrogen metallurgy, resource recycling and by-products, and carbon capture and utilization (CCU) are the main technologies tailored to the transformation pathways, and the optimization of energy consumption structure is an important direction for future development. Therefore, this paper believes that clean energy, as a guarantee for carbon mitigation, will play an increasingly important role in the process towards achieving carbon peaking and carbon neutrality goals (the “dual carbon” goals), in addition to the transformation of metallurgical technologies.
Semi-Supervised Heterogeneous Graph Learning with Multi-Level Data Augmentation
Authors: Chen Ying , Qiang Siwei , Ha Mingming , Liu Xiaolei , Li Shaoshuai , Tong Jiabi , Yuan Lingfeng , Guo Xiaobo , Zhu Zhenfeng
Published: August 2023

In recent years, semi-supervised graph learning with data augmentation (DA) has been the most commonly used and best-performing method to improve model robustness in sparse scenarios with few labeled samples. However, most existing DA methods are based on the homogeneous graph, but none are specific for the heterogeneous graph. Differing from the homogeneous graph, DA in the heterogeneous graph faces greater challenges: heterogeneity of information requires DA strategies to effectively handle heterogeneous relations, which considers the information contribution of different types of neighbors and edges to the target nodes. Furthermore, over-squashing of information is caused by the negative curvature formed by the non-uniformity distribution and the strong clustering in a complex graph. To address these challenges, this article presents a novel method named
HG-MDA
(Semi-Supervised Heterogeneous Graph Learning with Multi-Level Data Augmentation). For the problem of heterogeneity of information in DA, node and topology augmentation strategies are proposed for the characteristics of the heterogeneous graph. Additionally, meta-relation-based attention is applied as one of the indexes for selecting augmented nodes and edges. For the problem of over-squashing of information, triangle-based edge adding and removing are designed to alleviate the negative curvature and bring the gain of topology. Finally, the loss function consists of the cross-entropy loss for labeled data and the consistency regularization for unlabeled data. To effectively fuse the prediction results of various DA strategies, sharpening is used. Existing experiments on public datasets (i.e., ACM, DBLP, and OGB) and the industry dataset MB show that HG-MDA outperforms current SOTA models. Additionally, HG-MDA is applied to user identification in internet finance scenarios, helping the business to add 30% key users, and increase loans and balances by 3.6%, 11.1%, and 9.8%.
Reality-based UTXO Ledger
Authors: Müller Sebastian , Penzkofer Andreas , Polyanskii Nikita , Theis Jonas , Sanders William , Moog Hans
Published: August 2023

The Unspent Transaction Output (UTXO) model is commonly used in the field of Distributed Ledger Technology (DLT) to transfer value between participants. One of its advantages is that it allows parallel processing of transactions, as independent transactions can be added in any order. This property of order invariance and parallelisability has potential benefits in terms of scalability. However, since the UTXO Ledger is an append-only data structure, this advantage is compromised through the presence of conflicting transactions. We propose an extended UTXO Ledger model that optimistically updates the ledger and keeps track of the dependencies of the possible conflicts. In the presence of a conflict resolution mechanism, we propose a method to reduce the extended ledger back to a consistent UTXO Ledger.
Transactional Cross-Chain Smart Contract Invocations
Authors: Falazi Ghareeb , Breitenbücher Uwe , Leymann Frank , Schulte Stefan , Yussupov Vladimir
Published: August 2023

Blockchains have become increasingly important in recent years and have expanded their applicability to many domains beyond finance and cryptocurrencies. This adoption has particularly increased with the introduction of smart contracts, which are immutable, user-defined programs directly deployed on blockchain networks. However, many scenarios require business transactions to simultaneously access smart contracts on multiple, possibly heterogeneous blockchain networks while ensuring the atomicity and isolation of these transactions, which is not natively supported by current blockchain systems. Therefore, in this work, we introduce the Transactional Cross-Chain Smart Contract Invocation (TCCSCI) approach that supports such distributed business transactions while ensuring their global atomicity and serializability. The approach introduces the concept of Resource Manager Smart Contracts, and 2PC for Blockchains (2PC4BC), a client-driven Atomic Commit Protocol (ACP) specialized for blockchain-based distributed transactions. We validate our approach using a prototypical implementation, evaluate its introduced overhead, and prove its correctness.
Adverse Impact of Cannabis on Human Health
Authors: Chandy Mark , Nishiga Masataka , Wei Tzu-Tang , Hamburg Naomi M. , Nadeau Kari , Wu Joseph C.
Published: August 2023

Cannabis, the most commonly used recreational drug, is illicit in many areas of the world. With increasing decriminalization and legalization, cannabis use is increasing in the United States and other countries. The adverse effects of cannabis are unclear because its status as a Schedule 1 drug in the United States restricts research. Despite a paucity of data, cannabis is commonly perceived as a benign or even beneficial drug. However, recent studies show that cannabis has adverse cardiovascular and pulmonary effects and is linked with malignancy. Moreover, case reports have shown an association between cannabis use and neuropsychiatric disorders. With growing availability, cannabis misuse by minors has led to increasing incidences of overdose and toxicity. Though difficult to detect, cannabis intoxication may be linked to impaired driving and motor vehicle accidents. Overall, cannabis use is on the rise, and adverse effects are becoming apparent in clinical data sets.
Band Alignment of β-Ga2O3 with BaTiO3, SrTiO3, and Related Composites
Authors: Zhang Hongpeng , Chen Chengying , Jia Renxu , Xu Bei , Hu Jichao , Yuan Lei , Zhang Yuming , Zhang Hongyi , Zhang Yimen
Published: August 2023

Integrating perovskite oxides BaTiO3 (BTO), SrTiO3(STO) with β-Ga2O3 is of great interest for developing β-Ga2O3 power devices due to its promotion for improving uniformity in the electric field profile and breakdown characteristics. In this work, β-Ga2O3/BaTiO3 (BTO), β-Ga2O3/SrTiO3 (STO), β-Ga2O3/Ba0.5Sr0.5TiO3 (BSTO) heterojunction were epitaxially grown on sapphire substrates by low-pressure chemical vapor deposition (LPCVD) and radio frequency physical vapor deposition (RF PVD). The energy band alignment of β-Ga2O3/BaTiO3, β-Ga2O3/SrTiO3, β-Ga2O3/Ba0.5Sr0.5TiO3 (BSTO) heterojunction have been analyzed by X-ray photoemission spectroscopy and UV–visible transmittance spectrum. The conduction band offsets (∆E

c
) of β-Ga2O3/BTO, β-Ga2O3/STO, β-Ga2O3/BSTO is found to be 0.32 ± 0.05, 1.15 ± 0.05, 0.78 ± 0.05 eV, respectively; and the valence band offsets (∆E

v
) of these heterojunction is 0.76 ± 0.05 eV, 0.55 ± 0.05 eV, and 0.73 ± 0.05 eV, respectively. Our results indicate that type-I band alignment respectively form at these heterojunction, in which the valence and conduction bands of β-Ga2O3 are concomitantly higher than those of BTO, STO, and BSTO. The accurate determination of ∆E

c
and ∆E

v
is important for the design of β-Ga2O3/ferroelectric heterojunction multifunctional devices.
Multiobjective Reliability-Based Design Optimization of the Fuzzy Logic Controller for MR Damper-Based Structures
Authors: Pei Pei , Quek Ser Tong , Peng Yongbo
Published: August 2023

To devise an optimum and robust fuzzy logic controller for MR damper-based structures subjected to earthquake ground motions, the multiobjective reliability-based design optimization (RBDO) using the adaptive Kriging model is performed to determine the parameters of the fuzzy logic controller. The optimization problem is formulated with two objective functions, namely, the minimization of interstory drift and average control force of the concerned structure, and subjected to a probability constraint on structural dynamic responses under the effects of random structural stiffness and stochastic earthquake loadings. To reduce the computational cost of reliability assessment, a global Kriging model is constructed in an augmented space as a surrogate for computational evaluations. Subsequently, the trained metamodel combined with the nondominated sorting genetic algorithm (NSGA-II) is integrated into the framework of RBDO for solving the fuzzy logic control (FLC) optimization problem. The feasibility and effectiveness of the multiobjective RBDO in the FLC design are finally validated by conducting numerical simulations on both linear and nonlinear structures. As demonstrated in the linear case, the fuzzy logic controllers obtained from the multiobjective RBDO show more robustness than those derived from the multiobjective deterministic design optimization (DDO). In the nonlinear case, using the multiobjective DDO to prelocate a coarse safety domain can significantly reduce the number of samples for training the metamodel and facilitate the implementation of the multiobjective RBDO; in addition, the controlled structural performance with a specified fuzzy logic controller can be further improved by considering MR damper distribution optimization.
Characterization and Analysis of HEK293/Adenovirus Type 5 Cell Cultures under Simulated Microgravity Using Differential Neural Network Modeling
Authors: Tavira-Montalvan Carlos A. , Garcia-Gonzalez Alejandro , Meneses-Acosta Angélica
Published: August 2023

HEK293 cells are the common system to produce adenoviral vectors for vectorized vaccines and gene therapy products. Therefore, the improvement of this type of cell culture is highly relevant nowadays. Furthermore, the high aspect ratio vessel (HARV) bioreactor provides a simulated microgravity condition (SMGC) which allows the establishment of in vitro models of mammalian cells. The present work is aimed at showing the characterization of HEK293 cell cultures in serum‐free medium under SMGC and to identify a set of adaptable time differential equations from experimental data through a nonparametric mathematical modeling using differential neural networks (DNN). Results showed that the HARV bioreactor enables to obtain a gravity percentage equal to 〖%g〗_maximum = −0.053% (where minus sign implies against the gravity direction). In addition, the characterization of HEK293 culture under SMGC revealed that such condition favored the production of infective viral particles as well as the uptake of basic nutrients such as glucose and glutamine, but the cell concentration was not significantly affected. As shown, these results contribute to improve the adenoviral vector production, and the DNN analysis is useful to model the kinetic changes and to build the foundations for control strategies and optimization of adenoviral production in further studies.
Assessment of Drinking Water Quality in Urban Water Supply Systems: The Case of Hawassa City, Ethiopia
Authors: Mengstie Yirged Antehun , Desta Wendesen Mekonin , Alemayehu Esayas
Published: August 2023

In many developing countries, such as Ethiopia, water quality and the risk of water-related diseases are serious public health issues. The present study goal was to assess the drinking water quality from source to household tap water. To characterize and analyze drinking water quality parameters, 21 water samples were collected, of which 11 water samples were collected from sources (spring, borehole, and river), 4 from service reservoirs, and 6 from tap water. The mean values of the parameters were as follows: total dissolved solids (TDS) (142.79 mg/L), temperature (22.08°C), turbidity (9.49 NTU), electrical conductivity (EC) (250.14°μS/cm), pH (7.45 mg/L), fluoride (1.15 mg/L), nitrate (NO3−) (2.91 mg/L), total hardness (TH) (57.45 mg/L), calcium (41.7 6 mg/l), magnesium (10.74 mg/L), phosphate (0.44 mg/L), sulfate (3.99 mg/L), residual chlorine (1.53 mg/L), alkalinity (196.39 mg/L), and microbiological (total coliform and coliform/CFU) which were the main physiochemical parameters analyzed for the study. The findings revealed that the majority of the water quality parameters tested were within the WHO and National Drinking Water Quality Standards (NDWQS). However, some of the parameters such as temperature, turbidity, fluoride, and residual chlorine did not meet the standards. The mean temperatures at the source, reservoir, and tap water were 22.01°C 22.5°C,and 21.83°C, respectively. Turbidity levels in source samples ranged from 10 to 45 NTU, with a mean of 24.5 NTU, exceeding the WHO’s recommendation of less than 5 NTU. The Boko Alamura well had a high fluoride content (3.9 mg/l), which was above the WHO and NDWQS permissible limits. There was no free residual chlorine in the tap water sample. The results show that the Hawassa drinking water supply did not contain total or fecal coliform in any of the samples tested. The overall WQI for the water source, reservoir, and tap water was also determined to be 89, 71, and 69.7 points, respectively. Therefore, based on the WQI result, Hawassa drinking water quality is good for the source, reservoir, and tap water.
Reducción en la tasa de interés en julio: De los arrepentidos es el reino de los cielos
Authors: García Carlos J.
Published: August 2023

La tasa de interés de política monetaria (TPM) no solo es la tasa que cobra el Banco Central a los bancos comerciales, sino también tiene importantes efectos sobre la economía puesto que sirve de referencia para el resto del sistema financiero. Continuar leyendo...
Table S2 from Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma
Authors: Fan Fanfan , Gao Jian , Zhao Yue , Wang Jun , Meng Lu , Ma Jiaqiang , Li Teng , Han Han , Lai Jinglei , Gao Zhendong , Li Xiongfei , Guo Ran , Cao Zhiwei , Zhang Yang , Zhang Xiaoming , Chen Haiquan
Published: August 2023

Table S2
Table S1 from Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma
Authors: Fan Fanfan , Gao Jian , Zhao Yue , Wang Jun , Meng Lu , Ma Jiaqiang , Li Teng , Han Han , Lai Jinglei , Gao Zhendong , Li Xiongfei , Guo Ran , Cao Zhiwei , Zhang Yang , Zhang Xiaoming , Chen Haiquan
Published: August 2023

Table S1
Supplementary Data 3 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Authors: Chen Chen , Shin June Ho , Fang Zhuoqing , Brennan Kevin , Horowitz Nina B. , Pfaff Kathleen L. , Welsh Emma L. , Rodig Scott J. , Gevaert Olivier , Gozani Or , Uppaluri Ravindra , Sunwoo John B.
Published: August 2023

Western_imageJ data
Supplementary Table S2 from The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer
Authors: Li Zheqi , Li Tianqin , Yates Megan E. , Wu Yang , Ferber Amanda , Chen Lyuqin , Brown Daniel D. , Carroll Jason S. , Sikora Matthew J. , Tseng George C. , Oesterreich Steffi , Lee Adrian V.
Published: August 2023

Log2 (CPM+1) expression level of all genes and indication of low expression genes
Supplementary Table S1 from The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer
Authors: Li Zheqi , Li Tianqin , Yates Megan E. , Wu Yang , Ferber Amanda , Chen Lyuqin , Brown Daniel D. , Carroll Jason S. , Sikora Matthew J. , Tseng George C. , Oesterreich Steffi , Lee Adrian V.
Published: August 2023

Inventory of EstroGene Database
Supplementary FigureS1-S5 from The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer
Authors: Li Zheqi , Li Tianqin , Yates Megan E. , Wu Yang , Ferber Amanda , Chen Lyuqin , Brown Daniel D. , Carroll Jason S. , Sikora Matthew J. , Tseng George C. , Oesterreich Steffi , Lee Adrian V.
Published: August 2023

Supplementary FigureS1-S5
Supplementary Table 3. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

ETS family fusions detected in the WCDT samples
Supplementary Table 2. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

Molecular Charactersistcs of samples in WCDT cohort
Supplementary Figure 8. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

Gene expression level of Krüppel-like factor (KLF) family among the five mCRPC subtypes
Supplementary Figure 7. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

A heatmap representing the enrichment of transcription factors (TF) in hypermethylated regions of different subtypes of the WCDT samples
Supplemental Information from Intermetastatic and Intrametastatic Heterogeneity Shapes Adaptive Therapy Cycling Dynamics
Authors: Gallaher Jill , Strobl Maximilian , West Jeffrey , Gatenby Robert , Zhang Jingsong , Robertson-Tessi Mark , Anderson Alexander R.A.
Published: August 2023

Supplemental methods, tables, and figures
Supplementary Figure 4. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

Gene Ontology (GO) with Biological processes (BP) on the genes uniquely up- or down-regulated within each subtype
Supplementary Data 1. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

List of Differentially expressed genes in the subtypes of mCRPC in comparison with AR+/NE- tumors
Movie S2 from Intermetastatic and Intrametastatic Heterogeneity Shapes Adaptive Therapy Cycling Dynamics
Authors: Gallaher Jill , Strobl Maximilian , West Jeffrey , Gatenby Robert , Zhang Jingsong , Robertson-Tessi Mark , Anderson Alexander R.A.
Published: August 2023

Movies corresponding to simulation examples in Figure 4, comparing metastases simulations with different drug resistance and turnover.
Data from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

Abstract
Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen signaling. Androgen deprivation therapy and second-generation androgen receptor (AR)–targeted therapy selectively favor the development of treatment-resistant subtypes of metastatic castration-resistant prostate cancer (mCRPC), defined by AR and neuroendocrine (NE) markers. Molecular drivers of double-negative (AR−/NE−) mCRPC are poorly defined. In this study, we comprehensively characterized treatment-emergent mCRPC by integrating matched RNA sequencing, whole-genome sequencing, and whole-genome bisulfite sequencing from 210 tumors. AR−/NE− tumors were clinically and molecularly distinct from other mCRPC subtypes, with the shortest survival, amplification of the chromatin remodeler CHD7, and PTEN loss. Methylation changes in CHD7 candidate enhancers were linked to elevated CHD7 expression in AR−/NE+ tumors. Genome-wide methylation analysis nominated Krüppel-like factor 5 (KLF5) as a driver of the AR−/NE− phenotype, and KLF5 activity was linked to RB1 loss. These observations reveal the aggressiveness of AR−/NE− mCRPC and could facilitate the identification of therapeutic targets in this highly aggressive disease.
Significance:
Comprehensive characterization of the five subtypes of metastatic castration-resistant prostate cancer identified transcription factors that drive each subtype and showed that the double-negative subtype has the worst prognosis.
Data from Temozolomide Sensitizes ARID1A-Mutated Cancers to PARP Inhibitors
Authors: Yu Zheng-Cheng , Li Tianhe , Tully Ellen , Huang Peng , Chen Chih-Ning , Oberdoerffer Philipp , Gaillard Stephanie , Shih Ie-Ming , Wang Tian-Li
Published: August 2023

Abstract
ARID1A is a subunit of SWI/SNF chromatin remodeling complexes and is mutated in many types of human cancers, especially those derived from endometrial epithelium, including ovarian and uterine clear cell carcinoma (CCC) and endometrioid carcinoma (EMCA). Loss-of-function mutations in ARID1A alter epigenetic regulation of transcription, cell-cycle checkpoint control, and DNA damage repair. We report here that mammalian cells with ARID1A deficiency harbor accumulated DNA base lesions and increased abasic (AP) sites, products of glycosylase in the first step of base excision repair (BER). ARID1A mutations also delayed recruitment kinetics of BER long-patch repair effectors. Although ARID1A-deficient tumors were not sensitive to monotherapy with DNA-methylating temozolomide (TMZ), the combination of TMZ with PARP inhibitors (PARPi) potently elicited double-strand DNA breaks, replication stress, and replication fork instability in ARID1A-deficient cells. The TMZ and PARPi combination also significantly delayed in vivo growth of ovarian tumor xenografts carrying ARID1A mutations and induced apoptosis and replication stress in xenograft tumors. Together, these findings identified a synthetic lethal strategy to enhance the response of ARID1A-mutated cancers to PARP inhibition, which warrants further experimental exploration and clinical trial validation.
Significance:
The combination of temozolomide and PARP inhibitor exploits the specific DNA damage repair status of ARID1A-inactivated ovarian cancers to suppress tumor growth.
Bursting Tumor Bubbles to Improve CAR T-cell Therapy
Authors: Ortiz-Espinosa Sergio , Srivastava Shivani
Published: August 2023

Chimeric antigen receptor (CAR) T cells have had dramatic success in B-cell malignancies, but this efficacy has not yet translated to more common solid tumors. In this issue of Cancer Research, Zhong and colleagues demonstrated that tumor-derived small extracellular vesicles (sEV) contain CAR target antigens like mesothelin, enabling them to preferentially interact with and suppress the activity of CAR T cells in vivo. PD-L1 in tumor-derived sEVs increased upon CAR T-cell infusion and induced PD-L1–dependent suppression of CAR T cells that could be completely reversed by PD-L1 blockade. Strategies to inhibit sEV secretion, via genetic manipulation of tumor cells or pharmacologic inhibition, significantly improved CAR T-cell accumulation, function, and antitumor activity in vivo, suggesting that therapeutic targeting of sEV secretion could be a promising new approach to improving the efficacy of CAR T-cell therapy.

See related article by Zhong et al., p. 2790
Supplementary Data 1 from BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant EGFR Mutations in Non–Small Cell Lung Cancer
Authors: Lim Sun Min , Fujino Toshio , Kim Chulwon , Lee Gwanghee , Lee Yong-Hee , Kim Dong-Wan , Ahn Jin Seok , Mitsudomi Tetsuya , Jin Taiguang , Lee Sang-Yoon
Published: August 2023

Supplementary Appendix 1. Supplementary materials and methods
Supplemental Figure 4 from Early Changes in Circulating Cell-Free KRAS G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients
Authors: Paweletz Cloud P. , Heavey Grace A. , Kuang Yanan , Durlacher Emily , Kheoh Thian , Chao Richard C. , Spira Alexander I. , Leventakos Konstantinos , Johnson Melissa L. , Ou Sai-Hong Ignatius , Riely Gregory J. , Anderes Kenna , Yang Wenjing , Christensen James G. , Jänne Pasi A.
Published: August 2023

Supplemental Figure 4: Radiographic response of patients that cleared their plasma (teal) at cycle 4 versus that did not (red).
Supplemental Figure 3 from Early Changes in Circulating Cell-Free KRAS G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients
Authors: Paweletz Cloud P. , Heavey Grace A. , Kuang Yanan , Durlacher Emily , Kheoh Thian , Chao Richard C. , Spira Alexander I. , Leventakos Konstantinos , Johnson Melissa L. , Ou Sai-Hong Ignatius , Riely Gregory J. , Anderes Kenna , Yang Wenjing , Christensen James G. , Jänne Pasi A.
Published: August 2023

Supplemental Figure 3: Baseline AF% of patients with complete clearance and patients with incomplete clearance at C2.
Figure S2 from BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant EGFR Mutations in Non–Small Cell Lung Cancer
Authors: Lim Sun Min , Fujino Toshio , Kim Chulwon , Lee Gwanghee , Lee Yong-Hee , Kim Dong-Wan , Ahn Jin Seok , Mitsudomi Tetsuya , Jin Taiguang , Lee Sang-Yoon
Published: August 2023

Supplementary Figure 2. Activity of BBT-176 in EGFR WT and EGFR exon 20 insertion models.
Supplementary Table S8 from Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers
Authors: Rotow Julia , Patel Jyoti D. , Hanley Matthew P. , Yu Helena , Awad Mark , Goldman Jonathan W. , Nechushtan Hovav , Scheffler Matthias , Kuo Chih-Hsi S. , Rajappa Senthil , Harada Guilherme , Clifford Sarah , Santucci Alison , Silva Laura , Tupper Rebecca , Oxnard Geoffrey R. , Kherani Jennifer , Drilon Alexander
Published: August 2023

Combination therapy efficacy
Supplementary Table S6 from Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers
Authors: Rotow Julia , Patel Jyoti D. , Hanley Matthew P. , Yu Helena , Awad Mark , Goldman Jonathan W. , Nechushtan Hovav , Scheffler Matthias , Kuo Chih-Hsi S. , Rajappa Senthil , Harada Guilherme , Clifford Sarah , Santucci Alison , Silva Laura , Tupper Rebecca , Oxnard Geoffrey R. , Kherani Jennifer , Drilon Alexander
Published: August 2023

Dose discontinuation
Supplementary Table S2 from Patient-Reported Outcomes as Interradiographic Predictors of Response in Non–Small Cell Lung Cancer
Authors: Bhatt Ambika S. , Schabath Matthew B. , Hoogland Aasha I. , Jim Heather S.L. , Brady-Nicholls Renee
Published: August 2023

Representativeness of study participants table
Supplementary Table S2 from Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes
Authors: Pikkusaari Sanna , Tumiati Manuela , Virtanen Anni , Oikkonen Jaana , Li Yilin , Perez-Villatoro Fernando , Muranen Taru , Salko Matilda , Huhtinen Kaisa , Kanerva Anna , Koskela Heidi , Tapper Johanna , Koivisto-Korander Riitta , Joutsiniemi Titta , Haltia Ulla-Maija , Lassus Heini , Hautaniemi Sampsa , Färkkilä Anniina , Hynninen Johanna , Hietanen Sakari , Carpén Olli , Kauppi Liisa
Published: August 2023

Tumor percentages estimated from H&E images and comparison between HR, ovaHRDScar and Telli2016 status.
Supplementary Figure S7 from Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes
Authors: Pikkusaari Sanna , Tumiati Manuela , Virtanen Anni , Oikkonen Jaana , Li Yilin , Perez-Villatoro Fernando , Muranen Taru , Salko Matilda , Huhtinen Kaisa , Kanerva Anna , Koskela Heidi , Tapper Johanna , Koivisto-Korander Riitta , Joutsiniemi Titta , Haltia Ulla-Maija , Lassus Heini , Hautaniemi Sampsa , Färkkilä Anniina , Hynninen Johanna , Hietanen Sakari , Carpén Olli , Kauppi Liisa
Published: August 2023

Comparison of different fHR score cut-off values.
Supplementary Figure S5. from Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes
Authors: Pikkusaari Sanna , Tumiati Manuela , Virtanen Anni , Oikkonen Jaana , Li Yilin , Perez-Villatoro Fernando , Muranen Taru , Salko Matilda , Huhtinen Kaisa , Kanerva Anna , Koskela Heidi , Tapper Johanna , Koivisto-Korander Riitta , Joutsiniemi Titta , Haltia Ulla-Maija , Lassus Heini , Hautaniemi Sampsa , Färkkilä Anniina , Hynninen Johanna , Hietanen Sakari , Carpén Olli , Kauppi Liisa
Published: August 2023

Example images of staining patterns.
Supplementary Table S6 from DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
Authors: Tawk Bouchra , Rein Katrin , Schwager Christian , Knoll Maximilian , Wirkner Ute , Hörner-Rieber Juliane , Liermann Jakob , Kurth Ina , Balermpas Panagiotis , Rödel Claus , Linge Annett , Löck Steffen , Lohaus Fabian , Tinhofer Ingeborg , Krause Mechtild , Stuschke Martin , Grosu Anca Ligia , Zips Daniel , Combs Stephanie E. , Belka Claus , Stenzinger Albrecht , Herold-Mende Christel , Baumann Michael , Schirmacher Peter , Debus Jürgen , Abdollahi Amir
Published: August 2023

Supplementary Table S6. Contingency Table of Hypoxia-M and CD8-immunohistochemistry (IHC) staining for CD8-T cells
Figure 2 from Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes
Authors: Pikkusaari Sanna , Tumiati Manuela , Virtanen Anni , Oikkonen Jaana , Li Yilin , Perez-Villatoro Fernando , Muranen Taru , Salko Matilda , Huhtinen Kaisa , Kanerva Anna , Koskela Heidi , Tapper Johanna , Koivisto-Korander Riitta , Joutsiniemi Titta , Haltia Ulla-Maija , Lassus Heini , Hautaniemi Sampsa , Färkkilä Anniina , Hynninen Johanna , Hietanen Sakari , Carpén Olli , Kauppi Liisa
Published: August 2023

Low fHR scores correlate with better primary therapy response and with longer PFI. A, For patients with chemo-naïve samples, the median of fHR scores is lower in CR and PR groups compared with SD/PD (Mann–Whitney test, two-tailed). Only patients with fHRP tumors had SD/PD after primary therapy. B, The median of fHR scores was lower in CR and PR groups compared with SD/PD also for patients with fHR score from IDS/NACT-treated sample (Mann–Whitney test, two-tailed). C, Proportions of CR, PR, and SD/PD are significantly different between fHRP and fHRD groups (Fisher exact test, two-tailed). D and E, PFI and OS significantly correlate with lower fHR scores (linear regression). F, Multivariate hazard ratio analysis for PFI with fHR status and prognostic clinical parameters. The fHRD status and success of cytoreduction significantly correlated with longer PFI (Cox proportional hazards regression). Blue = fHRD, red = fHRP.
Supplementary Figure S4 from DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
Authors: Tawk Bouchra , Rein Katrin , Schwager Christian , Knoll Maximilian , Wirkner Ute , Hörner-Rieber Juliane , Liermann Jakob , Kurth Ina , Balermpas Panagiotis , Rödel Claus , Linge Annett , Löck Steffen , Lohaus Fabian , Tinhofer Ingeborg , Krause Mechtild , Stuschke Martin , Grosu Anca Ligia , Zips Daniel , Combs Stephanie E. , Belka Claus , Stenzinger Albrecht , Herold-Mende Christel , Baumann Michael , Schirmacher Peter , Debus Jürgen , Abdollahi Amir
Published: August 2023

Supplementary Figure 4 (Top). CD8 T cell enrichment is prognostic for Overall Survival (OS), local recurrence (LR) and disease progression but not for distant metastasis (DM) in HPV negative HNSCC in the DKTK-ROG cohort (n=88). (Bottom) After adjusting for Immune cell Infiltration, Hypoxia-M remained an independent prognosticator for local recurrence (HR=3.06, p<0.01) and for disease progression (HR=2.14, p<0.04) with a trend towards worsened OS (HR=1.92, p<0.09). CD8-IHC staining was an independent prognosticator for local recurrence (HR=0.41, p<0.03) an
Supplementary Fig. 7 from Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment
Authors: Rogers Leonard C. , Kremer Jeff C. , Brashears Caitlyn B. , Lin Zongtao , Hu Zhixian , Bastos Alliny C.S. , Baker Adriana , Fettig Nicole , Zhou Dong , Shoghi Kooresh I. , Dehner Carina A. , Chrisinger John S.A. , Bomalaski John S. , Garcia Benjamin A. , Oyama Toshinao , White Eileen P. , Van Tine Brian A.
Published: August 2023

Supplemental Figure 7. Gemcitabine and docetaxel increase toxicity to ASS1 KO tumor cells treated with ADI-PEG20 and either chloroquine or imipramine.
Supplementary Figure S4 from The DRD2 Antagonist Haloperidol Mediates Autophagy-Induced Ferroptosis to Increase Temozolomide Sensitivity by Promoting Endoplasmic Reticulum Stress in Glioblastoma
Authors: Shi Linyong , Chen Hanning , Chen Kunxiang , Zhong Chengzong , Song Chong , Huang Yifeng , Wang Tong , Chen Lei , Li Chiyang , Huang Annie , Qi Songtao , Li Hong , Lu Yuntao
Published: August 2023

Fig. S4. Autophagy, endoplasmic reticulum stress and cAMP pathway are involved in TMZ+HP-induced ferroptosis in GBM cells.
Supplementary Fig. 5 from Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment
Authors: Rogers Leonard C. , Kremer Jeff C. , Brashears Caitlyn B. , Lin Zongtao , Hu Zhixian , Bastos Alliny C.S. , Baker Adriana , Fettig Nicole , Zhou Dong , Shoghi Kooresh I. , Dehner Carina A. , Chrisinger John S.A. , Bomalaski John S. , Garcia Benjamin A. , Oyama Toshinao , White Eileen P. , Van Tine Brian A.
Published: August 2023

Supplemental Figure 5. Evidence against other possible growth support mechanisms and MEF toxicity.
Supplementary Fig. 3 from Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment
Authors: Rogers Leonard C. , Kremer Jeff C. , Brashears Caitlyn B. , Lin Zongtao , Hu Zhixian , Bastos Alliny C.S. , Baker Adriana , Fettig Nicole , Zhou Dong , Shoghi Kooresh I. , Dehner Carina A. , Chrisinger John S.A. , Bomalaski John S. , Garcia Benjamin A. , Oyama Toshinao , White Eileen P. , Van Tine Brian A.
Published: August 2023

Supplemental Figure 3. Fibroblasts support growth of Ass1 WT murine and human sarcoma cell lines.
Supplementary Tables 1 from Genetic Alterations Detected by Circulating Tumor DNA in HER2-Low Metastatic Breast Cancer
Authors: Hensing Whitney L. , Gerratana Lorenzo , Clifton Katherine , Medford Arielle J. , Velimirovic Marko , Shah Ami N. , D'Amico Paolo , Reduzzi Carolina , Zhang Qiang , Dai Charles S. , Denault Elyssa N. , Bagegni Nusayba A. , Opyrchal Mateusz , Ademuyiwa Foluso O. , Bose Ron , Behdad Amir , Ma Cynthia X. , Bardia Aditya , Cristofanilli Massimo , Davis Andrew A.
Published: August 2023

Supplementary Tables 1-7
Supplementary Table S6 from Frequent Overexpression of HER3 in Brain Metastases from Breast and Lung Cancer
Authors: Tomasich Erwin , Steindl Ariane , Paiato Christina , Hatziioannou Teresa , Kleinberger Markus , Berchtold Luzia , Puhr Rainer , Hainfellner Johannes A. , Müllauer Leonhard , Widhalm Georg , Eckert Franziska , Bartsch Rupert , Heller Gerwin , Preusser Matthias , Berghoff Anna Sophie
Published: August 2023

Pathway enrichment analysis of genes associated with differentially methylated CpG sites in HER3+ vs. HER3-
Supplemental Figure 2 from Genetic Alterations Detected by Circulating Tumor DNA in HER2-Low Metastatic Breast Cancer
Authors: Hensing Whitney L. , Gerratana Lorenzo , Clifton Katherine , Medford Arielle J. , Velimirovic Marko , Shah Ami N. , D'Amico Paolo , Reduzzi Carolina , Zhang Qiang , Dai Charles S. , Denault Elyssa N. , Bagegni Nusayba A. , Opyrchal Mateusz , Ademuyiwa Foluso O. , Bose Ron , Behdad Amir , Ma Cynthia X. , Bardia Aditya , Cristofanilli Massimo , Davis Andrew A.
Published: August 2023

Supplemental Figure 2. Interaction between HER2-low status and oncogenic pathways on overall survival.
Supplementary Figure S2 from Frequent Overexpression of HER3 in Brain Metastases from Breast and Lung Cancer
Authors: Tomasich Erwin , Steindl Ariane , Paiato Christina , Hatziioannou Teresa , Kleinberger Markus , Berchtold Luzia , Puhr Rainer , Hainfellner Johannes A. , Müllauer Leonhard , Widhalm Georg , Eckert Franziska , Bartsch Rupert , Heller Gerwin , Preusser Matthias , Berghoff Anna Sophie
Published: August 2023

Kaplan-Meier curves of patients with BM of A) Luminal-BCa B) HER2+ BCa C) TN-BCa, and D) NSCLC patients stratified according to the intensity of HER3 expression determined by IHC.
Supplementary Figures 1 from Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors
Authors: Sousa Luana Guimaraes , McGrail Daniel J. , Lazar Neto Felippe , Li Kaiyi , Marques-Piubelli Mario L. , Ferri-Borgogno Sammy , Dai Hui , Mitani Yoshitsugu , Spardy Burr Nicole , Cooper Zachary A. , Kinneer Krista , Cortez Maria Angelica , Lin Shiaw-Yih , Bell Diana , El Naggar Adel , Burks Jared , Ferrarotto Renata
Published: August 2023

Supplementary Figures
Figure S1 from A Multiparameter Molecular Classifier to Predict Response to Neoadjuvant Lapatinib plus Trastuzumab without Chemotherapy in HER2+ Breast Cancer
Authors: Veeraraghavan Jamunarani , Gutierrez Carolina , De Angelis Carmine , Davis Robert , Wang Tao , Pascual Tomas , Selenica Pier , Sanchez Katherine , Nitta Hiroaki , Kapadia Monesh , Pavlick Anne C. , Galvan Patricia , Rexer Brent , Forero-Torres Andres , Nanda Rita , Storniolo Anna M. , Krop Ian E. , Goetz Matthew P. , Nangia Julie R. , Wolff Antonio C. , Weigelt Britta , Reis-Filho Jorge S. , Hilsenbeck Susan G. , Prat Aleix , Osborne C. Kent , Schiff Rachel , Rimawi Mothaffar F.
Published: August 2023

Supplementary Figure S1. Study design and tissue availability for biomarker analysis.
Supplementary Table S3 from Clinical Relevance of BRCA1 Promoter Methylation Testing in Patients with Ovarian Cancer
Authors: Blanc-Durand Félix , Tang Roseline , Pommier Margaux , Nashvi Marzieh , Cotteret Sophie , Genestie Catherine , Le Formal Audrey , Pautier Patricia , Michels Judith , Kfoury Maria , Hervé Robert , Mengue Sylvie , Wafo Estelle , Elies Antoine , Miailhe Gregoire , Uzan Jennifer , Rouleau Etienne , Leary Alexandra
Published: August 2023

Clinical characteristics according to BRCA status
Supplementary Table S2 from Clinical Relevance of BRCA1 Promoter Methylation Testing in Patients with Ovarian Cancer
Authors: Blanc-Durand Félix , Tang Roseline , Pommier Margaux , Nashvi Marzieh , Cotteret Sophie , Genestie Catherine , Le Formal Audrey , Pautier Patricia , Michels Judith , Kfoury Maria , Hervé Robert , Mengue Sylvie , Wafo Estelle , Elies Antoine , Miailhe Gregoire , Uzan Jennifer , Rouleau Etienne , Leary Alexandra
Published: August 2023

Clinical data and outcomes of patients included
Supplementary Table S1 from Clinical Relevance of BRCA1 Promoter Methylation Testing in Patients with Ovarian Cancer
Authors: Blanc-Durand Félix , Tang Roseline , Pommier Margaux , Nashvi Marzieh , Cotteret Sophie , Genestie Catherine , Le Formal Audrey , Pautier Patricia , Michels Judith , Kfoury Maria , Hervé Robert , Mengue Sylvie , Wafo Estelle , Elies Antoine , Miailhe Gregoire , Uzan Jennifer , Rouleau Etienne , Leary Alexandra
Published: August 2023

Primer sequences for methylation analysis (methylation-specific ddPCR)
Supplementary Table S2 from Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non–Small Cell Lung Cancer: The Piedmont Study
Authors: Eisner Joel R. , Mayhew Gregory M. , Davison James M. , Beebe Kirk D. , Shibata Yoichiro , Guo Yuelong , Farhangfar Carol , Farhangfar Farhang , Uronis Joshua M. , Conroy Jeffrey M. , Milburn Michael V. , Hayes David Neil , Mileham Kathryn F.
Published: August 2023

Expression Matrix of Patient Tumor Sample RNAseq
Supplementary Figure S2 from Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non–Small Cell Lung Cancer: The Piedmont Study
Authors: Eisner Joel R. , Mayhew Gregory M. , Davison James M. , Beebe Kirk D. , Shibata Yoichiro , Guo Yuelong , Farhangfar Carol , Farhangfar Farhang , Uronis Joshua M. , Conroy Jeffrey M. , Milburn Michael V. , Hayes David Neil , Mileham Kathryn F.
Published: August 2023

Expression of Genes Associated with Antifolate (Pemetrexed) Activity by LUAD Subtype.
Supplementary Figure S1 from Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non–Small Cell Lung Cancer: The Piedmont Study
Authors: Eisner Joel R. , Mayhew Gregory M. , Davison James M. , Beebe Kirk D. , Shibata Yoichiro , Guo Yuelong , Farhangfar Carol , Farhangfar Farhang , Uronis Joshua M. , Conroy Jeffrey M. , Milburn Michael V. , Hayes David Neil , Mileham Kathryn F.
Published: August 2023

RNA Sequencing Quality Control Criteria
Supplementary Figure 1 from Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer
Authors: Ramkumar Kavya , Tanimoto Azusa , Della Corte Carminia M. , Stewart C. Allison , Wang Qi , Shen Li , Cardnell Robert J. , Wang Jing , Polanska Urszula M. , Andersen Courtney , Saeh Jamal , Pease J. Elizabeth , Travers Jon , Fabbri Giulia , Gay Carl M. , Urosevic Jelena , Byers Lauren A.
Published: August 2023

Supplementary Figure 1 shows BCL2 is a strong biomarker of resistance to AURK inhibition in SCLC.
Supplementary Data 1 from Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial
Authors: Ellingsen Espen B. , O'Day Steven , Mezheyeuski Artur , Gromadka Agnieszka , Clancy Trevor , Kristedja Timothy S. , Milhem Mohammed , Zakharia Yousef
Published: August 2023

Figure S1
Supplementary Table 1 from Phase I Trial of the Multi-kinase Inhibitor Cabozantinib, a CYP3A4 Substrate, plus CYP3A4-Interacting Antiretroviral Therapy in People Living with HIV and Cancer (AMC-087)
Authors: Haigentz Missak , Lee Jeannette Y. , Chiao Elizabeth Y. , Aboulafia David M. , Ratner Lee , Ambinder Richard F. , Baiocchi Robert A. , Mitsuyasu Ronald T. , Wachsman William , Sparano Joseph A. , Rudek Michelle A.
Published: August 2023

Supplementary Table 1. Representativeness of Study Participants
Supplementary Figure S4 from Evaluation of Somatic Mutations in Urine Samples as a Noninvasive Method for the Detection and Molecular Classification of Endometrial Cancer
Authors: Costas Laura , Onieva Irene , Pelegrina Beatriz , Marin Fátima , Carmona Álvaro , López-Querol Marta , Frias-Gomez Jon , Peremiquel-Trillas Paula , Martínez José Manuel , Dorca Eduard , Brunet Joan , Pineda Marta , Ponce Jordi , Matias-Guiu Xavier , de Sanjosé Silvia , Bosch Francesc Xavier , Alemany Laia , Paytubi Sonia
Published: August 2023

ROC curve showing the detection performance of the NGS test in supernatant urine samples