bluuebunny/crossref_metadata_2025 huggingface dataset:
Bletilla striata Oligosaccharides Improve Ulcerative Colitis by Regulating Gut Microbiota and Intestinal Metabolites in Dextran Sulfate Sodium-Induced Mice
Authors: Zhu Tianxiang , Hu Baifei , Ye Cheng , Hu Haiming , Yin Mingzhu , Zhang Zhigang , Li Shuiqing , Liu Yanju , Liu Hongtao
Published: April 2022

This study aimed to elucidate the mechanism of Bletilla striata oligosaccharides (BO) in the treatment of ulcerative colitis (UC). A UC mouse model was induced by 3% Dextran sodium sulfate (DSS), and BO (200 mg/kg/d) were administered for intervention. The results show that BO effectively inhibited the release of intestinal inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Also, BO profoundly elevated the secretion of mucins and the expression of tight junction (TJ) proteins to attenuate dysfunction of the intestinal barrier. The 16S rDNA sequencing and liquid chromatography/gas chromatography-mass spectrometer (LC/GC-MS) analysis of mouse feces revealed that BO regulated the disturbance of gut microbiota and intestinal metabolites. By using the in vitro fermentation broth of BO and gut microbiota-depleted mice treated with antibiotics, we confirmed the protection of BO against UC. In conclusion, BO played a role in improving UC by modulating gut microbial composition and intestinal metabolites, which provided new therapeutic strategies for UC treatment.
Novel MDM2 Inhibitor XR-2 Exerts Potent Anti-Tumor Efficacy and Overcomes Enzalutamide Resistance in Prostate Cancer
Authors: Wu Meng , Cui Jingyi , Hou Huimin , Li Ying , Liu Shengjie , Wan Li , Zhang Lili , Huang Wei , Sun Gaoyuan , Liu Jingchao , Jin Pengfei , He Shunmin , Liu Ming
Published: April 2022

Background: The inactivation of tumor-suppressor p53 plays an important role in second generation anti-androgens (SGAs) drug resistance and neuroendocrine differentiation in castration-resistant prostate cancer (CRPC). The reactivation of p53 by blocking the MDM2–p53 interaction represents an attractive therapeutic remedy in cancers with wild-type or functional p53. Whether MDM2-p53 inhibitor could overcome SGAs drug resistance in CRPC is still needed further research. Here, we investigated the anti-tumor efficacy and mechanisms of a novel MDM2-p53 inhibitor XR-2 in CRPC.

Methods: To investigate the functions and mechanisms of XR-2 in prostate cancer, in vitro and in vivo biofunctional assays were performed. Western blot and qRT-PCR assay were performed to detect the protein and mRNA expression levels of indicated genes. CCK8, colony formation, flow cytometry and senescence assays were performed for cell function identifications. RNA-sequencing and bioinformatics analysis were mainly used to identify the influence of XR-2 on prostate cancer cells transcriptome. Subcutaneous 22Rv1 derived xenografts mice model was used to investigate the in vivo anti-tumor activity of XR-2. In addition, the broad-spectrum anti-tumor activities in vivo of XR-2 were evaluated by different xenografts mice models.

Results: XR-2 could directly bind to MDM2, potently reactivate the p53 pathway and thus induce cell cycle arrest and apoptosis in wild-type p53 CRPC cell lines. XR-2 also suppresses the AR pathway as p53 regulates AR transcription inhibition and MDM2 participates in AR degradation. As a result, XR-2 efficiently inhibited CRPC cell viability, showed a synergistic effect with enzalutamide and overcame enzalutamide resistance both in vitro and in vivo. Moreover, results illustrated that XR-2 possesses broad-spectrum anti-tumor activities in vivo with favourable safety.

Conclusion: MDM2-p53 inhibitor (XR-2) possesses potently prostate cancer progresses inhibition activity both in vitro and in vivo. XR-2 shows a synergistic effect with enzalutamide and overcomes enzalutamide resistance.
Characteristics of Serum Metabolites and Gut Microbiota in Diabetic Kidney Disease
Authors: Zhang Bo , Wan Yuzhou , Zhou Xuefeng , Zhang Haojun , Zhao Hailing , Ma Liang , Dong Xi , Yan Meihua , Zhao Tingting , Li Ping
Published: April 2022

Disturbance of circulating metabolites and disorders of the gut microbiota are involved in the progression of diabetic kidney disease (DKD). However, there is limited research on the relationship between serum metabolites and gut microbiota, and their involvement in DKD. In this study, using an experimental DKD rat model induced by combining streptozotocin injection and unilateral nephrectomy, we employed untargeted metabolomics and 16S rRNA gene sequencing to explore the relationship between the metabolic profile and the structure and function of gut microbiota. Striking alterations took place in 140 serum metabolites, as well as in the composition and function of rat gut microbiota. These changes were mainly associated with carbohydrate, lipid, and amino acid metabolism. In these pathways, isomaltose, D-mannose, galactonic acid, citramalic acid, and prostaglandin B2 were significantly upregulated. 3-(2-Hydroxyethyl)indole, 3-methylindole, and indoleacrylic acid were downregulated and were the critical metabolites in the DKD model. Furthermore, the levels of these three indoles were restored after treatment with the traditional Chinese herbal medicine Tangshen Formula. At the genera level, g_Eubacterium_nodatum_group, g_Lactobacillus, and g_Faecalibaculum were most involved in metabolic disorders in the progression of DKD. Notably, the circulating lipid metabolites had a strong relationship with DKD-related parameters and were especially negatively related to the mesangial matrix area. Serum lipid indices (TG and TC) and UACR were directly associated with certain microbial genera. In conclusion, the present research verified the anomalous circulating metabolites and gut microbiota in DKD progression. We also identified the potential metabolic and microbial targets for the treatment of DKD.
Impact of Fabrication Processes of Small-Molecule-Doped Polymer Thin-Films on Room-Temperature Phosphorescence
Authors: Thomas Heidi , Haase Katherina , Achenbach Tim , Bärschneider Toni , Kirch Anton , Talnack Felix , Mannsfeld Stefan C. B. , Reineke Sebastian
Published: April 2022

The development of organic materials displaying room-temperature phosphorescence is a research field that has attracted more and more attention in the last years. Most studies focus on designing or optimizing emitter molecules to increase the phosphorescent performance in host:emitter systems. Rarely, the overall thin-film preparation routines are compared with respect to their triplet-state luminescence yield. Herein, different film preparation techniques are investigated using the very same emitter molecule. A variation of host polymer, post-annealing temperature, and fabrication procedure is evaluated with respect to the obtained phosphorescent lifetime, photoluminescent quantum yield, and phosphorescence-to-luminescence ratio. This study elaborates the importance of different film preparation techniques and gathers a concise set of data which is helpful to anyone optimizing the phosphorescence of a particular system.
Tunable Electronic Structure in Twisted Bilayer WTe2
Authors: Chen Zi-Si , Huang Lu , Guo Wen-Ti , Zhong Kehua , Zhang Jian-Min , Huang Zhigao
Published: April 2022

The moiré pattern restricts the electronic states of transition metal bilayers, thus extending the concept of the magic angle found in twisted bilayer graphene to semiconductors. Here, we have studied the electronic structure of the twisted bilayer WTe2 using first-principle calculations. Our result shows that a twist significantly changes the band structure, resulting in the bandgap engineering when the twisted bilayer of WTe2 is turning to a specific angle. The electronic structure is changed by the change of the twist angle. Interestingly, a semiconductor-to-metal phase transition is found at a twist angle of 15°. Our results provide a reference for the regulation of two-dimensional band structures. These results are important for understanding the electronic structure of twisted systems and for future applications in electronic devices.
Nonreciprocal Waveguide-QED for Spinning Cavities with Multiple Coupling Points
Authors: Liu Wenxiao , Lin Yafen , Li Jiaqi , Wang Xin
Published: April 2022

We investigate chiral emission and the single-photon scattering of spinning cavities coupled to a meandering waveguide at multiple coupling points. It is shown that nonreciprocal photon transmissions occur in the cavities-waveguide system, which stems from interference effects among different coupling points, and frequency shifts induced by the Sagnac effect. The nonlocal interference is akin to the mechanism in giant atoms. In the single-cavity setup, by optimizing the spinning velocity and number of coupling points, the chiral factor can approach 1, and the chiral direction can be freely switched. Moreover, destructive interference gives rise to the complete photon transmission in one direction over the whole optical frequency band, with no analogy in other quantum setups. In the multiple-cavity system, we also investigate the photon transport properties. The results indicate a directional information flow between different nodes. Our proposal provides a novel way to achieve quantum nonreciprocal devices, which can be applied in large-scale quantum chiral networks with optical waveguides.
Association of Gastric Myoelectrical Activity With Ghrelin, Gastrin, and Irisin in Adults With Metabolically Healthy and Unhealthy Obesity
Authors: Abulmeaty Mahmoud M. A. , Aldisi Dara , Aljuraiban Ghadeer S. , Almajwal Ali , El Shorbagy Eman , Almuhtadi Yara , Albaran Batool , Aldossari Zaid , Alsager Thamer , Razak Suhail , Berika Mohammed , Al Zaben Mohamed
Published: April 2022

Background and Objective: Functional disturbances of gastric myoelectrical activity (GMA) might exist in obesity. However, studies on its association with the gastric hormones in obesity phenotypes are lacking. The objective was to study the association of GMA with the serum levels of key gastric hormones in different obesity phenotypes.

Methods: A total of 139 adults (31.00 ± 11.12 years) were classified into different metabolic phenotypes of obesity: 1) normal weight-lean (NWL group): BMI <25 kg/m2 and the fat-mass index (FMI) ≤9.7 kg/m2 in females and ≤6.3 kg/m2 in males; 2) metabolically obese normal weight (MONW group): BMI <25 kg/m2 and FMI >9.7 kg/m2 in females and >6.3 kg/m2 in males; 3) metabolically healthy obese (MHO group): BMI ≥25 and FMI ≤9.7 kg/m2 in females and ≤6.3 kg/m2 in males; and 4) metabolically unhealthy obese (MUO group): BMI ≥25 and FMI >9.7 kg/m2 in females and >6.3 kg/m2 in males. The GMA was measured at the baseline and post-prandial state using a multichannel electrogastrography with a water load satiety test. The average power distribution by the frequency region and the average dominant frequency were used for analysis. Anthropometric measurements and bioelectric impedance analysis were performed to calculate the FMI and fat-free mass index (FFMI). Serum levels of ghrelin, gastrin, and irisin were measured by ELISA kits according to the manufacturer’s protocol.

Results: Compared to the NWL group, gastrin and ghrelin levels were significantly low in the MUO participants, while irisin was significantly high. The EGG showed significantly lower baseline and 20-min normogastria frequencies in the MHO and MUO groups. In the MHO group, baseline duodenal frequency was positively correlated with the gastrin level, while normogastria times were positively associated with the irisin level and negatively associated with the ghrelin level. In the MUO group, percentages of bradygastria frequencies at 10, 20, and 30 min were positively correlated with the BMI and FFMI. This bradygastria was correlated positively with the irisin level and negatively with the ghrelin level.

Conclusion: The EGG patterns might be associated with obesity-related gastric hormones in different obesity phenotypes. EGG may be a promising clinical tool in obesity assessment. The association of the EGG patterns with hormonal levels needs further investigation for potential practical uses.
Computational Prediction of Thrombosis in Food and Drug Administration’s Benchmark Nozzle
Authors: Qiao Yonghui , Luo Kun , Fan Jianren
Published: April 2022

Thrombosis seriously threatens human cardiovascular health and the safe operation of medical devices. The Food and Drug Administration’s (FDA) benchmark nozzle model was designed to include the typical structure of medical devices. However, the thrombosis in the FDA nozzle has yet not been investigated. The objective of this study is to predict the thrombus formation process in the idealized medical device by coupling computational fluid dynamics and a macroscopic hemodynamic-based thrombus model. We developed the hemodynamic-based thrombus model by considering the effect of platelet consumption. The thrombus model was quantitatively validated by referring to the latest thrombosis experiment, which was performed in a backward-facing step with human blood flow. The same setup was applied in the FDA nozzle to simulate the thrombus formation process. The thrombus shaped like a ring was firstly observed in the FDA benchmark nozzle. Subsequently, the accuracy of the shear-stress transport turbulence model was confirmed in different turbulent flow conditions. Five scenarios with different Reynolds numbers were carried out. We found that turbulence could change the shape of centrosymmetric thrombus to axisymmetric and high Reynolds number blood flow would delay or even prevent thrombosis. Overall, the present study reports the thrombosis process in the FDA benchmark nozzle using the numerical simulation method, and the primary findings may shed light on the effect of turbulence on thrombosis.
Comprehensive Characterization of Arterial and Cardiac Function in Marfan Syndrome—Can Biomarkers Help Improve Outcome?
Authors: Weismann Constance G. , Hlebowicz Joanna , Åkesson Anna , Liuba Petru , Hanseus Katarina
Published: April 2022

Background: Marfan Syndrome (MFS) has been associated with increased aortic stiffness and left ventricular dysfunction. The latter may be due to the underlying genotype and/or secondary to aortic stiffening (vascular-ventricular interaction). The aim of this study was to characterize arterial and cardiac function in MFS using a multimodal approach.

Methods: Prospective observational study of MFS patients and healthy controls. Methods included echocardiography, ascending aortic distensibility, common carotid intima media thickness [cIMT], parameters of wave reflection, carotid-femoral pulse wave velocity [cfPWV]), reactive hyperemia index [RHI], and biomarker analysis (Olink, CVII panel).

Results: We included 20 patients with MFS and 67 controls. Ascending aortic distensibility, cIMT and RHI were decreased, while all parameters of arterial wave reflection, stiffness and BNP levels were increased in the MFS group. Both systolic and diastolic function were impaired relative to controls. Within the MFS group, no significant correlation between arterial and cardiac function was identified. However, cfPWV correlated significantly with indexed left ventricular mass and volume in MFS. Bran natriuretic peptide (BNP) was the only biomarker significantly elevated in MFS following correction for age and sex.

Conclusions: MFS patients have generally increased aortic stiffness, endothelial dysfunction and BNP levels while cIMT is decreased, supporting that the mechanism of general stiffening is different from acquired vascular disease. CfPWV is associated with cardiac size, blood pressure and BNP in MFS patients. These may be early markers of disease progression that are suitable for monitoring pharmacological treatment effects in MFS patients.
A Comparative Study of Flavonoids and Carotenoids Revealed Metabolite Responses for Various Flower Colorations Between Nicotiana tabacum L. and Nicotiana rustica L.
Authors: Xiao Qinzhi , Zhu Yueyi , Cui Guoxian , Zhang Xianwen , Hu Risheng , Deng Zhengyu , Lei Lei , Wu Liwen , Mei Lei
Published: April 2022

Tobacco is a model plant for studying flower coloration. Flavonoids and carotenoids were reported to contribute to the flower color in many plants. We investigated the mechanism underlying flower color formation in tobacco by comparing the profiling flavonoids and carotenoids between various species Nicotiana tabacum L. and Nicotiana rustica L., as their flowers commonly presented red (pink) and yellow (orange), respectively. The metabolomes were conducted by UPLC–ESI–MS/MS system. The main findings were as follows: (1) A total of 31 flavonoids and 36 carotenoids were identified in all four cultivars involved in N. tabacum and N. rustica. (2) Flavonoids and carotenoids tended to concentrate in the red flowers (N. tabacum) and yellow flowers (N. rustica), respectively. (3) About eight flavonoids and 12 carotenoids were primarily screened out for metabolic biomarkers, such as the robust biomarker involving kaempferol-3-o-rut, quercetin-glu, rutin, lutein, and β-carotene. This is the first research of systematic metabolome involving both flavonoids and carotenoids in tobacco flower coloration. The metabolic mechanism concluded that flavonoids and carotenoids mainly contributed to red (pink) and yellow (orange) colors of the tobacco flowers, respectively. Our finding will provide essential insights into characterizing species and modifying flower color in tobacco breeding through genetic improvement or regulation of featured metabolic synthesis.
A Loosely Coupled Extended Kalman Filter Algorithm for Agricultural Scene-Based Multi-Sensor Fusion
Authors: Lv Meibo , Wei Hairui , Fu Xinyu , Wang Wuwei , Zhou Daming
Published: April 2022

With the arrival of aging society and the development of modern agriculture, the use of agricultural robots for large-scale agricultural production activities will become a major trend in the future. Therefore, it is necessary to develop suitable robots and autonomous navigation technology for agricultural production. However, there is still a problem of external noise and other factors causing the failure of the navigation system. To solve this problem, we propose an agricultural scene-based multi-sensor fusion method via a loosely coupled extended Kalman filter algorithm to reduce interference from external environment. Specifically, the proposed method fuses inertial measurement unit (IMU), robot odometer (ODOM), global navigation and positioning system (GPS), and visual inertial odometry (VIO), and uses visualization tools to simulate and analyze the robot trajectory and error. In experiments, we verify the high accuracy and the robustness of the proposed algorithm when sensors fail. The experimental results show that the proposed algorithm has better accuracy and robustness on the agricultural dataset than other algorithms.
Does Fluctuating Light Affect Crop Yield? A Focus on the Dynamic Photosynthesis of Two Soybean Varieties
Authors: Salvatori Nicole , Alberti Giorgio , Muller Onno , Peressotti Alessandro
Published: April 2022

In natural environments, plants are exposed to variable light conditions, but photosynthesis has been mainly studied at steady state and this might overestimate carbon (C) uptake at the canopy scale. To better elucidate the role of light fluctuations on canopy photosynthesis, we investigated how the chlorophyll content, and therefore the different absorbance of light, would affect the quantum yield in fluctuating light conditions. For this purpose, we grew a commercial variety (Eiko) and a chlorophyll deficient mutant (MinnGold) either in fluctuating (F) or non-fluctuating (NF) light conditions with sinusoidal changes in irradiance. Two different light treatments were also applied: a low light treatment (LL; max 650 μmol m−2 s−1) and a high light treatment (HL; max 1,000 μmol m−2 s−1). Canopy gas exchanges were continuously measured throughout the experiment. We found no differences in C uptake in LL treatment, either under F or NF. Light fluctuations were instead detrimental for the chlorophyll deficient mutant in HL conditions only, while the green variety seemed to be well-adapted to them. Varieties adapted to fluctuating light might be identified to target the molecular mechanisms responsible for such adaptations.
Function of Protein Kinases in Leaf Senescence of Plants
Authors: Yang Fengbo , Miao Yuchen , Liu Yuyue , Botella Jose R. , Li Weiqiang , Li Kun , Song Chun-Peng
Published: April 2022

Leaf senescence is an evolutionarily acquired process and it is critical for plant fitness. During senescence, macromolecules and nutrients are disassembled and relocated to actively growing organs. Plant leaf senescence process can be triggered by developmental cues and environmental factors, proper regulation of this process is essential to improve crop yield. Protein kinases are enzymes that modify their substrates activities by changing the conformation, stability, and localization of those proteins, to play a crucial role in the leaf senescence process. Impressive progress has been made in understanding the role of different protein kinases in leaf senescence recently. This review focuses on the recent progresses in plant leaf senescence-related kinases. We summarize the current understanding of the function of kinases on senescence signal perception and transduction, to help us better understand how the orderly senescence degeneration process is regulated by kinases, and how the kinase functions in the intricate integration of environmental signals and leaf age information.
A Meta-Analysis of the Relationships Between Emotional Intelligence and Employee Outcomes
Authors: Doǧru Çaǧlar
Published: April 2022

Emotional intelligence is an emerging field since the 1990s due to its important outcomes for employees. This study is a psychometric meta-analysis examining the links between emotional intelligence and organizational commitment, organizational citizenship behavior, job satisfaction, job performance, and job stress of employees. In this meta-analysis, carefully selected studies on emotional intelligence since the origin of the concept in 1990 were included along with studies examining its outcomes. For this analysis, three streams of emotional intelligence, consistent with previous meta-analyses, were considered: ability, self-report, and mixed emotional intelligence. This meta-analysis is an attempt to add to the literature by analyzing the relationships between emotional intelligence and selected employee outcomes over a period of time beginning in 1990. The three streams of emotional intelligence were separately analyzed to examine their relationship with employee outcomes. These outcomes were included in the study based on select research studies. Our study results showed that emotional intelligence and its three streams were positively related to organizational commitment, organizational citizenship behavior, job satisfaction, and job performance and negatively related to job stress.
A Research on Online Education Behavior and Strategy in University
Authors: Deng Quan
Published: April 2022

After the reform and opening up in China, through a series of rapid developments in world, online education has grown both socially and economically. This area has become representative of the fast-growing economy. However, Guangfu culture as a crucial component of Cantonese traditional culture is gradually becoming less influential today. It is the college's responsibility and duty to protect, carry forward, and inherit this traditional culture. Especially during this cyber era, where networks have become a powerful source for communication and study, there are diversified methods of adaptive learning and various learning behaviors. This article aims to analyze the plausibility of adapting an online platform into the teaching arena and the needs of students under this teaching mode. A simulation of applying advanced technology and artificial intelligence into Guangfu culture innovation was also conducted. The contribution shows the users in this platform have a longer study time, compared with non-platform users, and are more interested in traditional culture knowledge than non-users; 21.5% higher in the performance's test.
An Infectious Silver Lining: Is There a Positive Relationship Between Recovering From a COVID Infection and Psychological Richness of Life?
Authors: Dahlen Micael , Thorbjørnsen Helge
Published: April 2022

This paper draws from the recent literature on psychological richness of life (PRL), conceptualized as a third dimension of a good life which would be particularly desirable when happiness or meaning in life cannot be satisfactory attained, to investigate whether recovering from a COVID infection could be associated with PRL. We hypothesize that people who have recovered from being infected by the virus rate their PRL higher than those who have not been infected. Two cross-sectional studies (n = 937, and n = 1,012) support the hypothesis, and also found that people who recovered from a COVID infection were less prone to want to delete the pandemic time period from their life line and reported lower levels of death anxiety. The findings have implications for coping both on a societal and individual level, by changing perspectives and valuing the richness of positive as well as negative experiences, as well as counteracting repetitiveness and tedium and stimulating new experiences and reflection. The findings also have implications for future research on well-being, which could be informed by expanding the perspective from living well to a life well-lived, and future research on PRL and coping in terms of investigating causalities and interaction effects.
Basic Motor Competencies of 6- to 8-Year-Old Primary School Children in 10 European Countries: A Cross-Sectional Study on Associations With Age, Sex, Body Mass Index, and Physical Activity
Authors: Wälti Marina , Sallen Jeffrey , Adamakis Manolis , Ennigkeit Fabienne , Gerlach Erin , Heim Christopher , Jidovtseff Boris , Kossyva Irene , Labudová Jana , Masaryková Dana , Mombarg Remo , De Sousa Morgado Liliane , Niederkofler Benjamin , Niehues Maike , Onofre Marcos , Pühse Uwe , Quitério Ana , Scheuer Claude , Seelig Harald , Vlček Petr , Vrbas Jaroslav , Herrmann Christian
Published: April 2022

Basic motor competencies (BMC) are a prerequisite for children to be physically active, participate in sports and thus develop a healthy, active lifestyle. The present study provides a broad screening of BMC and associations with age, sex, body mass index (BMI) and extracurricular physical activity (PA) in 10 different European countries. The different country and regional contexts within Europe will offer a novel view on already established BMC associations. The cross-sectional study was conducted in 11 regions in 10 European countries in 2018. The motor competence areas, object movement (OM) and self-movement (SM), were assessed using the MOBAK-1-2 test instrument in 3758 first and second graders (age: M = 6.86 ± 0.60 years; 50% girls) during Physical Education classes. Children were questioned about their extracurricular PA and age. Their body weight and height were measured in order to calculate BMI. Statistical analyses included variances and correlations. The results showed significant differences in BMC levels between countries (OM: F = 18.74, p < 0.001, η2 = 0.048; SM: F = 73.10, p < 0.001, η2 = 0.163) whereas associations between BMC and correlates were similar. Boys performed significantly better in OM while girls performed better in SM. Age was consistently positively related to OM and SM with older children reaching higher levels of BMC than younger ones. While participation rates for extracurricular PA differed widely, participation in ball sports was correlated with OM and SM. Participation in individual sports showed a significant association with SM. In summary, BMC levels of children seem to depend on where they live and are strongly related to their participation in extracurricular PA. Therefore, education and health policies, in order to enhance motor competence development and PA participation, are recommended. Further research on country-specific Physical Education frameworks and their influence on BMC will provide more insights into structural factors and cultural characteristics of BMC development. On a school level, support tools and educational materials for teachers about BMC may enable children to achieve a basic level of motor competencies through Physical Education, contributing to lifelong participation in PA.
Water and Meadow Views Both Afford Perceived but Not Performance-Based Attention Restoration: Results From Two Experimental Studies
Authors: Johnson Katherine A. , Pontvianne Annabelle , Ly Vi , Jin Rui , Januar Jonathan Haris , Machida Keitaro , Sargent Leisa D. , Lee Kate E. , Williams Nicholas S. G. , Williams Kathryn J. H.
Published: April 2022

Attention Restoration Theory proposes that exposure to natural environments helps to restore attention. For sustained attention—the ongoing application of focus to a task, the effect appears to be modest, and the underlying mechanisms of attention restoration remain unclear. Exposure to nature may improve attention performance through many means: modulation of alertness and one’s connection to nature were investigated here, in two separate studies. In both studies, participants performed the Sustained Attention to Response Task (SART) before and immediately after viewing a meadow, ocean, or urban image for 40 s, and then completed the Perceived Restorativeness Scale. In Study 1 (n = 68), an eye-tracker recorded the participants’ tonic pupil diameter during the SARTs, providing a measure of alertness. In Study 2 (n = 186), the effects of connectedness to nature on SART performance and perceived restoration were studied. In both studies, the image viewed was not associated with participants’ sustained attention performance; both nature images were perceived as equally restorative, and more restorative than the urban image. The image viewed was not associated with changes in alertness. Connectedness to nature was not associated with sustained attention performance, but it did moderate the relation between viewing the natural images and perceived restorativeness; participants reporting a higher connection to nature also reported feeling more restored after viewing the nature, but not the urban, images. Dissociation was found between the physiological and behavioral measures and the perceived restorativeness of the images. The results suggest that restoration associated with nature exposure is not associated with modulation of alertness but is associated with connectedness with nature.
Fostering Self-Regulated Learning in Online Environments: Positive Effects of a Web-Based Training With Peer Feedback on Learning Behavior
Authors: Bellhäuser Henrik , Liborius Patrick , Schmitz Bernhard
Published: April 2022

Although training in self-regulated learning (SRL) is effective in improving performance, human trainers can reach only a few people at a time. We developed a web-based training for potentially unlimited numbers of participants based on the process model of SRL by Schmitz and Wiese (2006). A prior study (Bellhäuser et al., 2016) observed positive effects on self-reported SRL and self-efficacy. In the present randomized controlled trial, we investigated an improved version of the web-based training, augmented by the application of peer feedback groups. Prospective university students in an online mathematics preparation course were assigned randomly to one of four experimental conditions: Group D (diary), group TD (training + diary), group TDP (training + diary + peer feedback group), and group C (control). Complete data was obtained for 136 participants (78.8% male; M = 19.8 years). The learning diary was intended to trigger goal setting, planning, and self-motivation in the morning and reflection in the evening. The web-based training consisted of three lessons (approximately 90 min each) with videos, presentations, self-tests, and exercises. In the peer feedback condition, participants were randomly assigned to groups of five persons each and used a bulletin board to discuss pre-defined topics related to the content of the web-based training. Outcome measures included a test of declarative SRL knowledge, an SRL questionnaire, a general self-efficacy scale, log file data, and a mathematics test. Results showed positive effects for the web-based training, particularly when combined with peer feedback on both SRL knowledge and SRL questionnaires, self-efficacy, and on objective time-investment, but not on the mathematics test. The learning diary did not exhibit positive effects. We conclude that additional peer-feedback seems to be a useful supplement to web-based trainings with comparably low organizational costs.
The Benefits of Being Proactive While Working Remotely: Leveraging Self-Leadership and Job Crafting to Achieve Higher Work Engagement and Task Significance
Authors: Costantini Arianna , Weintraub Jared
Published: April 2022

Given the growing number of remote and hybrid working arrangements, this research investigates the process and outcomes of proactivity during remote work. We approach proactivity during remote working as a resource-building process and integrate self-leadership and job crafting literature. We propose that employees’ self-leadership allows them to regulate their resources optimally, enabling resource availability that can be used to arrange remote working demands and resources proactively. We collected three-wave data from remote workers (n = 329 observations) and tested our hypotheses using multilevel analyses. Results differed by level of analysis. Specifically, at the between level, comparing behaviors between participants, social expansion mediated the relationship between self-goal setting and task significance. In contrast, at the within level (analyzing differences in behavior within the same person), social expansion mediated the relationship between self-goal setting and work engagement. Overall, these findings suggest that self-leadership allows higher availability of resources enabling the proactive initiation of social interactions, which, at the within level enhance work engagement, and at the between level improve task significance during remote work. We discuss these findings considering the implications for interventions to foster more positive remote-work experiences.
Wellbeing in Winter: Testing the Noticing Nature Intervention During Winter Months
Authors: Passmore Holli-Anne , Yargeau Alissa , Blench Joslin
Published: April 2022

The main objective of this 2-week RCT study was to test the efficacy of the previously developed Noticing Nature Intervention (NNI) to boost wellbeing during winter months. The NNI consists of noticing the everyday nature encountered in one’s daily routine and making note of what emotions are evoked. Community adults (N = 65) were randomly assigned to engage in the NNI or were assigned to one of two control conditions. Paired t-tests revealed significant increases pre- to post-intervention in the NNI group for positive affect (d = 0.43), elevation (d = 0.59), nature connectedness (d = 0.46), and hope agency (d = 0.64), and a marginally significant increase in transcendent connectedness (d = 0.41). No significant pre-post difference emerged for any aspect of wellbeing in the control conditions. Analysis of qualitative findings revealed that negative emotion themes were 2.13 times more likely to be associated with built photos than with nature photos. Feelings of peace, awe, happiness, humbleness, and hope were more likely to be associated with nature photos, while feelings of annoyance, loneliness, curiosity, uncertainty, anger, yearning, and comfortableness were more likely to be associated with built photos. Overall, results indicated that engaging in the NNI can provide a wellbeing boost, even in the cold of winter. This study is the first (to our knowledge) to test any nature-based wellbeing intervention during colder, winter months, and to directly assess the impact of a nature-based wellbeing intervention on levels of hope.
Modeling and Analyzing the Impact of the Internet of Things-Based Industry 4.0 on Circular Economy Practices for Sustainable Development: Evidence From the Food Processing Industry of China
Authors: Sun Xiaoli , Wang Xuan
Published: April 2022

The Industry 4.0 concept proposes that new cutting-edge technologies, such as the Internet of Things (IoT), will grow. The acceptance of IoT in the circular economy (CE) is still in its infancy, despite its enormous potential. In the face of growing environmental affairs, IoT based Industry 4.0 technologies are altering CE practices and existing business models, according to the World Economic Forum. This research investigates the function of IoT-based Industry 4.0 in circular CE practices, as well as their impact on economic and environmental performance, which in turn influences overall organizational performance. China-based enterprises provide information for the study, which includes data from 300 companies. Utilizing a structural equation modeling framework known as partial least squares structural equation modeling (PLS-SEM). The major findings are presented in the study: (I) the IoT significantly improves the activities of the CE; (II) the IoT significantly improves the practices of the CE; and (III) the IoT meaningfully advances the practices of CE (green manufacturing, circular design, remanufacturing, and recycling). Moreover, the findings shows that environmentally friendly business practices help enhance environmental performance of firm, while also stimulating their economic performance; and improved environmental performance has a significant positive influence on firm performance. This research lays the groundwork for contributing nations/companies to attain economic and long-term sustainability goals at the same time by incorporating IoT-based Industry 4.0 technology into CE practices.
Dynamic Effects of Immersive Bilingualism on Cortical and Subcortical Grey Matter Volumes
Authors: Marin-Marin Lidón , Costumero Victor , Ávila César , Pliatsikas Christos
Published: April 2022

Bilingualism has been shown to induce neuroplasticity in the brain, but conflicting evidence regarding its specific effects in grey matter continues to emerge, probably due to methodological differences between studies, as well as approaches that may miss the variability and dynamicity of bilingual experience. In our study, we devised a continuous score of bilingual experiences and we investigated their non-linear effects on regional GM volume in a sample of young healthy participants from an immersive and naturalistic bilingual environment. We focused our analyses on cortical and subcortical regions that had been previously proposed as part of the bilingual speech pipeline and language control network. Our results showed a non-linear relationship between bilingualism score and grey matter volume of the inferior frontal gyrus. We also found linear increases in volumes of putamen and cerebellum as a function of bilingualism score. These results go in line with predictions for immersive and naturalistic bilingual environments with increased intensity and diversity of language use and provide further evidence supporting the dynamicity of bilingualism’s effects on brain structure.
Effects of Social Participation and Its Diversity, Frequency, and Type on Depression in Middle-Aged and Older Persons: Evidence From China
Authors: Wang Jiahui , Xu Jiao , Nie Yizhen , Pan Pochuan , Zhang Xin , Li Ye , Liu Huan , Liang Libo , Gao Lijun , Wu Qunhong , Hao Yanhua , Shah Saleh
Published: April 2022

Background

Depression is one of the greatest public health problems worldwide. The potential benefit of social participation (SP) on mental health has been widely acknowledged. Nevertheless, a few studies have used propensity score matching (PSM) to reduce the influence of data bias and confounding variables. This study explored the effect of social participation on depression among middle-aged and older Chinese persons through a PSM method, considering the frequency, type, and quantity of SP. Effects were compared among different age groups, genders, and places of residence.

Methods

The datasets were obtained from the 2018 wave of the China Health and Retirement Longitudinal Study. A total of 9,404 respondents aged 45 and above were included in the study. PSM and ordinary least squares methods were used to estimate the effect of social participation on depression.

Results

PSM estimation results showed that SP had a significantly positive effect on decreasing depression scores (p < 0.001) by 0.875–0.898 compared with persons without SP. All types of SP had a significantly positive effect (p < 0.001), and participating in community activities had the largest effect (β = −1.549 to −1.788, p < 0.001). Higher frequency of participation and more types of SP promoted lower depression scores; subgroup analyses revealed that the promotion effect was significantly greater among women, those aged ≥75 years, and those living in urban areas.

Conclusion

PSM indicated that SP could alleviate the depression of middle-aged and older Chinese persons. Targeted measures should be adopted to promote SP and thereby improve mental health and promote healthy and active aging.
Religion and the Mediating Role of Alexithymia in the Mental Distress of Healthcare Workers During the Coronavirus Disease 2019 Pandemic in a Psychiatric Hospital in China
Authors: Zhao Fushuai , Lung Hsuan , Chen Po-Fei , Chang Mei-Chung , Lung For-Wey
Published: April 2022

The outbreak of the coronavirus disease 2019 (COVID-19) has created unprecedented challenges to the healthcare system, religion, and alexithymic trait that impacts the psychological resilience of healthcare workers during the COVID-19 pandemic. This study aimed to investigate the role religion and alexithymia play in mental distress and the level of happiness of psychiatric hospital healthcare workers in China amidst the COVID-19 pandemic. Furthermore, whether symptom dimensions (anxiety, depression, hostility, inferiority, and insomnia) are associated with the level of happiness, and a 6-month follow-up was also investigated. A total of one-hundred and ninety healthcare workers were recruited from a psychiatric hospital in Jilin, China, and 122 were followed up after 6 months. All participants filled out the 20-item Toronto Alexithymia Scale, five-item Brief-Symptom Rating Scale, and the Chinese Oxford Happiness Questionnaire. The mental distress of healthcare workers decreased from 2.6 to 1.5% in 6-months. Religious belief was not associated with the mental distress or happiness of healthcare workers. Instead, for those whose anxiety decreased over 6 months, their social adaptation status increased. For those whose inferiority level decreased over time, their perceived level of psychological well-being and overall happiness increased. In over half a century of living in different societies, religion stabilizes the mental health of those in Taiwan amidst the stress of the COVID-19 pandemic, but not in China. However, both regions found healthcare workers with alexithymic traits experienced a higher level of mental distress, implying that the collectivist culture of Confucian philosophy continues to influence the emotional expression and alexithymic traits of healthcare workers in China and Taiwan. To ensure a healthy and robust clinical workforce in the treatment and control of the pandemic, the cultural impact on the psychological resilience of medical workers needs to be addressed.
The Mechanisms Behind Rapid Antidepressant Effects of Ketamine: A Systematic Review With a Focus on Molecular Neuroplasticity
Authors: Kang Melody J. Y. , Hawken Emily , Vazquez Gustavo Hector
Published: April 2022

The mechanism of action underlying ketamine’s rapid antidepressant effects in patients with depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD), including treatment resistant depression (TRD), remains unclear. Of the many speculated routes that ketamine may act through, restoring deficits in neuroplasticity may be the most parsimonious mechanism in both human patients and preclinical models of depression. Here, we conducted a literature search using PubMed for any reports of ketamine inducing neuroplasticity relevant to depression, to identify cellular and molecular events, relevant to neuroplasticity, immediately observed with rapid mood improvements in humans or antidepressant-like effects in animals. After screening reports using our inclusion/exclusion criteria, 139 publications with data from cell cultures, animal models, and patients with BD or MDD were included (registered on PROSPERO, ID: CRD42019123346). We found accumulating evidence to support that ketamine induces an increase in molecules involved in modulating neuroplasticity, and that these changes are paired with rapid antidepressant effects. Molecules or complexes of high interest include glutamate, AMPA receptors (AMPAR), mTOR, BDNF/TrkB, VGF, eEF2K, p70S6K, GSK-3, IGF2, Erk, and microRNAs. In summary, these studies suggest a robust relationship between improvements in mood, and ketamine-induced increases in molecular neuroplasticity, particularly regarding intracellular signaling molecules.
Abuse of Non-opioid Analgesics in Germany: Prevalence and Associations Among Self-Medicated Users
Authors: Rauschert Christian , Seitz Nicki-Nils , Olderbak Sally , Pogarell Oliver , Dreischulte Tobias , Kraus Ludwig
Published: April 2022

Background

Abuse of non-opioid analgesics (NOA) is associated with serious health consequences. However, due to inconsistent definitions of NOA abuse, prevalence estimates for the German population are unclear.

Objectives

This study aimed to estimate the 12-month prevalence of NOA abuse among self-medicated users of these drugs in the general German population and to identify risk factors.

Methods

Data are from the 2015 Epidemiological Survey of Substance Abuse, a nationally representative sample with 9,204 individuals aged 18–64 years. Classification of NOA abuse was based on self-reported information according to the definition of the ICD-10-GM diagnosis F55.2 abuse of non-dependence producing substances. Multiple logistic regression was performed to examine associations between NOA abuse and sociodemographic, behavioral, and health-related variables.

Results

The weighted 12-month prevalence of NOA abuse was 14.6% (95%-CI [13.2- 16.0]) among self-medicated users of these drugs. Extrapolation of the proportion of individuals abusing NOA to the German population aged 18 to 64 is 3,243,396 individuals or 6.4% (95%-CI [5.7- 7.1]). Inexplicable physical pain, being underweight, depression, hazardous alcohol use, daily smoking, illegal drug use, and frequent use of NOA (one or more times per week and daily use) were associated with an increased probability of NOA abuse. The use of cannabis was associated with a lower probability of NOA abuse.

Conclusion

Abuse of NOA is highly prevalent in the German population. Against the background of increasing self-medication of NOA, healthcare providers need to be aware of potential risk factors of abuse to better identify and prevent this problem.