bluuebunny/crossref_metadata_2025 huggingface dataset:
lncRNA H19 Aggravates Brain Injury in Rats following Experimental Intracerebral Hemorrhage via NF-κB Pathway
Authors: Mao Shuaidong , Huang Huan , Chen Xianzheng
Published: January 2022

Objective. To explore the effect of long noncoding RNA H19 (lncRNA H19) on brain injury in rats following experimental intracerebral hemorrhage (ICH). Methods. Rat ICH model was established with type IV collagenase. The neurological function scores were evaluated, and the water content in brain tissue was measured. The nerve injury indexes, inflammatory factors, and oxidative stress indexes were also measured. Moreover, the expression of lncRNA H19 was determined by qRT-PCR, and Western blot detected NF-κB pathway-related protein expression. Results. Compared with the sham group, the neurological function scores, the water content in brain tissue, and levels of injury indicators myelin basic protein (MBP), S-100B, and neuron-specific enolase (NSE) in the ICH rats were significantly increased. Meanwhile, the levels of TNF-α, IL-6, IL-1β, ROS, and MDA were significantly increased, but the levels of SOD were significantly decreased. In addition, the expression of lncRNA H19 in the brain tissue in the ICH group was significantly higher than that in the sham group. After further interference with lncRNA H19 expression (sh-H19 group), the levels of all the above indicators were reversed and the neurological damage was improved. Western blot results showed that the expression of NF-κBp65 and IKKβ was significantly higher, and IκBα expression was lower in the perivascular hematoma tissue in the ICH group compared with the sham group. Compared with the sh-NC group, NF-κBp65 and IKKβ expression were significantly lower and IκBα was significantly higher in the sh-H19 group. Conclusion. lncRNA H19 exacerbated brain injury in rats with ICH by promoting neurological impairment, brain edema, and releasing inflammatory responses and oxidative stress. This may be related to the activation of NF-κB signaling pathway.
Intuitionistic Fuzzy Prioritized Aggregation Operators Based on Priority Degrees with Application to Multicriteria Decision-Making
Authors: Al-Kenani Ahmad N. , Anjum Rukhshanda , Islam Sahidul
Published: January 2022

In practise, intuitionistic fuzzy numbers (IFNs) are particularly useful for describing ambiguous data. We look at multicriteria decision-making (MCDM) problems with a prioritising relationship between the parameters. The concept of a priority degree is presented. The aggregation operators (AOs) are formed by assigning nonnegative real numbers to stringent priority levels, known as priority degrees. As a result, we construct “intuitionistic fuzzy prioritized averaging operator with priority degrees” and “intuitionistic fuzzy prioritized geometric operator with priority degrees,” which are both prioritized operators. The attributes of the existing method are frequently compared to those of other current approaches, stressing the superiority of the provided work over other methods now in use. In addition, the impact of priority degrees on the overall result is thoroughly investigated. Furthermore, in the intuitionistic fuzzy set (IFS) context, a decision-making strategy is proposed based on these operators. To highlight the efficacy of the proposed approach, an illustrative example relating to the selection of the best choice is considered.
Dynamical Behavior of Stochastic Markov Switching Hepatitis B Epidemic Model with Saturated Incidence Rate
Authors: Lu Chun
Published: January 2022

The article researches a stochastic hepatitis B epidemic model with saturated incidence rate, which is perturbed by both white noise and colored noise. Firstly, we obtain a significant criterion

R

0

S

which relies on environmental noises. By means of Lyapunov function approach, we show that there is a stationary distribution if

R

0

S

>
1

. Its condition implies that when white noise is small, in the stochastic model, there exists a stochastic positive equilibrium state without changing the basic properties of its corresponding deterministic model. Secondly, we derive sufficient criteria for extinction of the disease. Finally, we propose a definition of the solution to an impulsive stochastic functional differential equation with Markovian switching (ISFDM).
The Impact of Bullwhip Effect on the Cash Flow in Two‐Parallel Supply Chain Systems with the Competition Effect
Authors: Chen Xingji , Zeng Jing , Yuan Xigang
Published: January 2022

While considering the competition effect and market share, this study discusses how the cash flow bullwhip effect (CFBE) is impacted in two‐product and two‐parallel supply chain systems by comparing the situation that it has one kind of product in two‐level supply chain (SC). Specifically, the study aimed to examine two‐product and two‐parallel SC systems that include two suppliers and two retailers. Assuming that the demand function is a linear relationship of price self‐sensitivity coefficient and price cross‐sensitivity coefficient, which is an AR(1) process, two retailers share the demand. After that, the quantitative equation of the CFBE was deduced from two‐product and two‐parallel SC systems. Finally, we get the condition that the competition effect and the market share increase or decrease the CFBE, which was in contrast to the situation without the competition effect and the market share. The paper suggested that the manager can cooperate with their partner if two products are substitutable. On the other hand, the firm should improve the forecasting accuracy of the customer’s demand and improve the service quality so that it can increase the market share and reduce the CFBE in two‐parallel SC systems.
Potent In Vitro Phosphodiesterase 1 Inhibition of Flavone Isolated from Pistacia integerrima Galls
Authors: Rauf Abdur , Bawazeer Sami , Herrera-Bravo Jesús , Raza Muslim , Naz Humaira , Gul Somia , Muhammad Naveed , Almarhoon Zainab M. , Mabkhot Yahia N. , Ramadan Mohamed Fawzy , Setzer William N. , Daştan Sevgi Durna , Mahmud Shafi , Sharifi-Rad Javad
Published: January 2022

To prospect an isozyme‐specific, effective inhibitor against the physiologically‐crucial enzyme phosphodiesterase 1 (PDE1), phytochemicals from Pistacia integerrima galls were screened. The chloroform fraction of gall extract was subjected to column chromatographic which led to the isolation of compound 1, elucidated to be 5‐hydroxy‐7‐methoxy‐2‐(4‐methoxyphenyl)‐4H‐chromen‐4‐one (a flavone). In vitro and in silico PDE1 inhibitory activity of the compound 1 was investigated. EDTA, a known PDE1 inhibitor, was used as the reference. The flavone exhibited in vitro attenuation towards snake venom PDE1. IC50 response was superior to the standard chelator. An in silico molecular docking study was carried out using 3D structure of PDE1 to study the binding interactions of compound 1. The docking study predicted that flavone had a lower binding affinity (‐7.6 kcal/mol) and total energy (‐95 kcal/mol) score compared to EDTA. The minimal energy associated with the ligand‐protein complex implied that isolated compound 1 can serve as a therapeutic agent against PDE1 enzyme‐provoked ailments like asthma, hypertension, schizophrenia, and erectile dysfunction.
hsa_circWDR37_016 Regulates Hypoxia-Induced Proliferation of Pulmonary Arterial Smooth Muscle Cells
Authors: Li Shan-Shan , Liang Shuang , Long Yao , Chen Xu , Jin Xin
Published: January 2022

Pulmonary arterial hypertension (PAH) is characterized by abnormal remodeling of pulmonary vessel walls caused by excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Our previous clinical studies have demonstrated the importance of the downregulated circRNA in PAH. However, the role of upregulated circRNAs is still elusive. Here, we identified the upregulated circRNA in PAH patients, hsa_circWDR37_016 (circWDR37), as a key regulator of hypoxic proliferative disorder of pulmonary arterial smooth muscle cells (PASMCs). Quantitative real-time PCR (qRT-PCR) analysis validated that exposure to hypoxia markedly increased the circWDR37 level in cultured human PASMCs. As evidenced by flow cytometry, 5-ethynyl-2

′

-deoxyuridine (EdU) incorporation, wound healing, and Tunel assay, silencing of endogenous circWDR37 attenuated proliferation and cell-cycle progression in hypoxia-exposed human PASMCs in vitro. Furthermore, bioinformatics and Luciferase assay showed that circWDR37 directly sponged hsa-miR-138-5p (miR-138) and was involved in the immunoregulatory and inflammatory processes of PAH. Together, these studies suggested new insights into circRNA regulated the pathology of PAH, providing a new potential therapeutic target for PAH treatment.
X-Shaped Slotted Patch Biomedical Implantable Antenna for Wireless Communication Networks
Authors: Ahmad Sarosh , Manzoor Bilal , Naseer Salman , Santos-Valdivia Nilton , Ghaffar Adnan , Abbasi Muhammad Inam
Published: January 2022

Biomedical implantable antennas have a major role in biomedical telemetry applications. Therefore, a compact-size low-profile implantable antenna working in industrial, scientific, and medical (ISM) band at 915 MHz is presented. The presented antenna is a simple slotted patch fed with a coaxial probe of 50 Ω impedance. The patch consists of four slotted resonators printed on a flexible Roger Duroid RT5880 substrate (

ε

r

=
2.2

,

tan
δ
=
0.0009

) with the standard thickness of 0.254 mm. The complete volume of the designed antenna is

7
 
mm
×
7
 
mm
×
0.254
 
mm

(

0.08

λ

g

×
0.08

λ

g

×
0.003

λ

g

). The antenna covers the bandwidth from 800 MHz to 1 GHz (200 MHz) inside skin tissue. A good agreement between the simulation and measurements of the antenna has been obtained. Finally, the specific absorption rate (SAR) values have also been analyzed through simulations as 8.17 W/kg inside skin over 1 g of mass tissue. The proposed SAR values are less than the limit of the Federal Communications Commission (FCC). This antenna is miniaturized and an ideal applicant for applications in biomedical implants.
Investigations of Optical Coulomb Blockade Oscillations in Plasmonic Nanoparticle Dimers
Authors: Gudata Lamessa , Tesfaye Jule Leta , Saka Abela , Shanmugam R. , Dwarampudi L. Priyanka , Nagaprasad Nagaraj , Stalin B. , Krishnaraj Ramaswamy
Published: January 2022

The exploration of Coulomb blockade oscillations in plasmonic nanoparticle dimers is the subject of this study. When two metal nanoparticles are brought together at the end of their journey, tunnelling current prevents an infinite connection dipolar plasmon and an infinite amplification in the electric fields throughout the hot spot in between nanoparticles from occurring. One way to think about single-electron tunnelling through some kind of quantum dot is to think about Coulomb blockage oscillations in conductance. The electron transport between the dot and source is considered. The model of study is the linear conductance skilled at describing the basic physics of electronic states in the quantum dot. The linear conductance through the dot is defined as

G
=

lim

⟶
0

I
/
V

in the limit of infinity of small bias voltage. We discuss the classical and quantum metallic Coulomb blockade oscillations. Numerically, the linear conductance was plotted as a function gate voltage. The Coulomb blockade oscillation occurs as gate voltage varies. In the valleys, the conductance falls exponentially as a function gate voltage. As a result of our study, the conductance is constant at high temperature and does not show oscillation in both positive and negative gate voltages. At low temperature, conductance shows oscillation in both positive and negative gate voltages.
The Effect of Breathing Exercise Using Bubble Blower on Anxiety and Pain during Inferior Alveolar Nerve Block in Children Aged 7 to 10 Years: A Crossover Randomized Clinical Trial
Authors: Bahrololoomi Zahra , Sadeghiyeh Tahereh , Rezaei Maedeh , Maghsoudi Nahid
Published: January 2022

Introduction. The aim of this study was to evaluate the effect of breathing exercise using bubble blower on anxiety and pain during inferior alveolar nerve block (IANB) in children aged 7 to 10 years. Materials and Methods. In this randomized crossover clinical trial, thirty-five children with moderate to severe anxiety requiring bilateral pulp therapy of mandibular primary molars were enrolled. Based on random lists, 18 children received the BE + IANB and 17 children received a routine IANB at the first session. This trend became reverse at the second visit for each child. Anxiety was measured using Facial Image Scale (FIS), blood pressure, and pulse rate. Face Leg Activity Cry Consolability (FLACC) scale and Wong–Baker Facial Pain Scale (WBFPS) were used for pain measurement. The Paired Samples Test, Wilcoxon Signed Rank Test, and Interclass Correlation Coefficient were used for data analysis. Results. The means of FLACC, WBFPS, FIS, blood pressure, and pulse rate were higher at the control visit. However, these differences were statistically significant only for FLACC scale and WBFPS (

P

value <0.05). In subgroup analysis, only girls and children without any previous dental treatment showed significant differences in FLACC scale and WBFPS between the control and bubble blower side (

P

value <0.05). Conclusion. Breathing exercise using a bubble blower may be an efficient distraction and relaxation method to decrease pain of 7- to 10-year-old children with moderate to severe anxiety during inferior alveolar nerve block. However, anxiety levels were lower when applying BE, and the differences were not statistically significant.
Clinical Relevance and Tumor Growth Suppression of Mitochondrial ROS Regulators along NADH:Ubiquinone Oxidoreductase Subunit B3 in Thyroid Cancer
Authors: Zhu Jiao , Zheng Xiaobo , Lu Dan , Zheng Yun , Liu Jun
Published: January 2022

Mitochondrial reactive oxygen species (mitoROS) are a double-edged sword in cancer progression, connoting the ROS-dependent malignant transformation and the oxidative stress-induced cell death. However, the underlying role of mitoROS in thyroid cancer remains unclear. Here, we collected 35 prominent mitoROS regulators to stratify 510 thyroid cancer patients in TCGA cohort through consensus clustering. Three molecular subtypes (cluster 1/2/3) were identified, among which cluster 1 (mitoROSlow) was preferentially associated with unfavorable prognosis. Individually, there were 12 regulators with a high expression that predicted a significantly favorable progression-free survival. The NADH:Ubiquinone Oxidoreductase Subunit B3 (NDUFB3) had a highest impact. NDUFB3 knockdown significantly reduced mitoROS levels in BCPAP and C643 cells. Bioinformatically, the consistency between NDUFB3 expression and cluster 1/2/3 was confirmed; lower expression of NUDFB3 was associated with a poor clinical outcome. Pathway analysis of differentially expressed genes in the NDUFB3low and NDUFB3high cohorts revealed a predominance of oxidative phosphorylation pathway changes. Consistently, mitochondrial functions, including oxygen consumption rate, ATP levels, complex I activity, mitoROS levels, and the expression of mitochondrially encoded NADH:Ubiquinone oxidoreductase core subunit 5, were significantly increased in NDUFB3-overexpressed BCPAP cells or C643 cells. The in vivo NDUFB3 overexpression and sideroxylin treatment significantly suppressed tumor growth and prolonged survival, concurrently elevating mitoROS levels ex vivo in mouse xenograft models. Conversely, NDUFB3 knockdown had the opposite effect. Together, these findings implicated the importance of mitoROS regulators in predicting clinical outcomes of patients with thyroid cancer. Our findings may pave the way for developing a mitoROS-based treatment for thyroid cancer patients.
Analyzing the Association between Pattern and Returns Using Goodman–Kruskal Prediction Error Reduction Index (λ)
Authors: Paul Parmod Kumar , Mahela Om Prakash , Khan Baseem
Published: January 2022

For selecting and interpreting appropriate behaviour of proportion between buy/neutral/sell patterns and high/moderate/low returns, the prediction error reduction index is a very useful tool. It is operationally interpretable in terms of the proportional reduction in error of estimation. We first obtain the buy/sell pattern using an Optimal Band. The analysis of the association between patterns and returns is based on the Goodman–Kruskal prediction error reduction index (λ). Empirical analysis suggests that the prediction of returns from patterns is more impressive or of less error as compared to the prediction of patterns from returns. We demonstrated the prediction index for Index NIFTY 50, BANK‐NIFTY, and NIFTY‐IT of NSE (National Stock Exchange), for the period 2010–2020.
Inflammatory Bowel Disease Therapeutics: A Focus on Probiotic Engineering
Authors: Mishra Jayshree , Stubbs Madyson , Kuang Longxiang , Vara Nitza , Kumar Priyam , Kumar Narendra
Published: January 2022

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal (GI) tract with dysregulated mucosal immune functions and disturbed commensal ecosystem of the intestinal lumen. IBD is categorized into two major subsets: Crohn’s disease (CD) and ulcerative colitis (UC). Though advent of biologics has shifted the treatment with relatively longer remission compared to small molecule pharmaceuticals, patients still suffer from long-term complications. Since gut-microbiome is now accepted as another human organ holding potential for long-lasting human health, probiotics, and its engineering hold great promises to treat several previously untreatable chronic inflammatory conditions including IBD. Several emerging biological engineering tools have unlimited potential to manipulate probiotic bacterial system. These can produce useful therapeutic biologics with a goal to either ameliorate and/or treat previously untreatable chronic inflammatory conditions. As gut-microbiome is diverse and vary in different ethnic, geographic, and cultural human population, it will be important to develop vision for personalized probiotic treatment and develop the technology thereof to make personalized probiotic options a reality. The aim of this review paper is to present an overview of the current knowledge on both pharmacological and nonpharmacological IBD treatment modalities with a special emphasis on probiotic strains that are developed through the probiotic engineering. These engineered probiotics contain the most anti-inflammatory cytokines found within the human immune response and are currently being used to treat the intestinal inflammation in IBD for the IBD treatment.
A Self-Learning BP Neural Network Assessment Algorithm for Credit Risk of Commercial Bank
Authors: Liu Lulu
Published: January 2022

Commercial banks play an important role in the financial system, and their role in the processes of capital circulation, capital integration, capital resource allocation, and total social demand and supply adjustment is irreplaceable. This paper proposes the idea of constructing a credit risk evaluation system for commercial banks based on BPNN by combining qualitative and quantitative analysis, based on computer technology and management theory. Its main goal is to use a neural network’s self-learning ability to perform complex loan risk assessment. BPNN is capable of self-learning, self-adaptation, and knowledge acquisition, as well as dealing well with uncertainty. It is a nonlinear method that eliminates obvious subjective and artificial factors, resulting in a more objective and effective evaluation result. Experiments show that the established model is effective in regulating personal credit management and reducing investment risks for commercial banks, as well as providing a new decision-making framework for banks’ personal credit business.
Adult Hippocampal Neurogenesis in Alzheimer’s Disease: An Overview of Human and Animal Studies with Implications for Therapeutic Perspectives Aimed at Memory Recovery
Authors: Farioli-Vecchioli Stefano , Ricci Valentina , Middei Silvia
Published: January 2022

The mammalian hippocampal dentate gyrus is a niche for adult neurogenesis from neural stem cells. Newborn neurons integrate into existing neuronal networks, where they play a key role in hippocampal functions, including learning and memory. In the ageing brain, neurogenic capability progressively declines while in parallel increases the risk for developing Alzheimer’s disease (AD), the main neurodegenerative disorder associated with memory loss. Numerous studies have investigated whether impaired adult neurogenesis contributes to memory decline in AD. Here, we review the literature on adult hippocampal neurogenesis (AHN) and AD by focusing on both human and mouse model studies. First, we describe key steps of AHN, report recent evidence of this phenomenon in humans, and describe the specific contribution of newborn neurons to memory, as evinced by animal studies. Next, we review articles investigating AHN in AD patients and critically examine the discrepancies among different studies over the last two decades. Also, we summarize researches investigating AHN in AD mouse models, and from these studies, we extrapolate the contribution of molecular factors linking AD-related changes to impaired neurogenesis. Lastly, we examine animal studies that link impaired neurogenesis to specific memory dysfunctions in AD and review treatments that have the potential to rescue memory capacities in AD by stimulating AHN.
Calculation of Equivalent and Toric Power in AddOn Lenses Based on a Monte Carlo Simulation
Authors: Langenbucher Achim , Schrecker Jens , Cayless Alan , Hoffmann Peter , Wendelstein Jascha , Szentmáry Nóra
Published: January 2022

Introduction: Additional lenses implanted in the ciliary sulcus (AddOn) are one option for permanent correction of refractive error or generate pseudoaccommodation in the pseudophakic eye. The purpose of this paper was to model the power and magnification behaviour of toric AddOn and to show the effect sizes with a Monte Carlo simulation. Methods: Anonymized data of a cataractous population uploaded for formula constant optimization were extracted from the IOLCon platform. After filtering out data with refractive spherical equivalent (RSEQ) between −0.75 and 0.25 dpt and refractive cylinder (RCYL) lower than 0.75, for each of the N = 6,588 records, a toric AddOn was calculated which transfers the refraction error from spectacle plane to AddOn plane using a matrix-based calculation strategy based on linear Gaussian optics. The equivalent (AddOnEQ) and toric (AddOnCYL) power of the AddOn and the overall lateral magnification change and meridional magnification were derived for the situations before and after AddOn implantation, and a linear modelling was fitted for all 4 parameters. Results: RSEQ is the dominant effect size in the prediction of AddOnEQ and overall change in magnification (ΔM), whereas the lens position (LP), corneal thickness (CCT), and mean corneal radius (CPa) play a minor role. In a simplified model, AddOnEQ can be estimated by 0.0179 + 1.4104 RSEQ. RCYL and corneal radius difference (CPad) are the dominant effect sizes in the prediction of AddOnCYL and the change in meridional magnification (ΔMmer), whereas LP, CCT, CPa, and RSEQ play a minor role. In a simplified model, AddOnCYL can be predicted by −0.0005 + 0.0328 CPad + 1.4087 RCYL. Myopic eyes gain in overall magnification, whereas in hyperopic eyes, we observe a loss. Meridional distortion could be in general reduced to 35% on average with a toric AddOn. Conclusion: Our simulation shows that with a linear model, the equivalent and toric AddOn power, as well as overall change in magnification, meridional distortion before and after AddOn implantation, and the reduction in meridional distortion, can be easily predicted from the biometric data in pseudophakic eyes with moderate refractive error.
Emerging Technologies in Electrophysiology: From Single-Chamber to Biventricular Leadless Pacemakers
Authors: Gill Jashan
Published: January 2022

Background: Transvenous pacemakers have been shown to improve quality of life and mortality in patients with bradycardia and cardiac conduction blocks. However, they possess inevitable drawbacks as they have a relatively high incidence of lead and device pocket-related complications. Therefore, leadless pacemakers have emerged as a solution to reduce the complications seen with conventional pacemakers. However, there have been no clinical trials to date comparing transvenous to leadless pacemakers. Summary: Currently, the Micra™ transcatheter pacing system or AV device has been approved for commercial use worldwide but is limited to single-chamber pacing with single- or dual-chamber sensing. Although the leadless pacemaker Nanostim™ was initially promising, it has been recalled due to concerns of battery failures and is no longer approved in Europe. In addition, the lack of defibrillation capabilities with leadless pacemakers has been a limiting factor; therefore, a leadless pacemaker with the already approved subcutaneous cardioverter-defibrillator system is currently being studied in humans. Moreover, the WiSE cardiac resynchronization therapy (CRT) device has been approved in Europe, with the capabilities for leadless CRT in patients with unsuitable coronary sinus anatomy. Furthermore, retrieval of leadless pacemakers has been an area of concern; however, clinic data have signaled toward safe extraction of these devices with minimal complications. Key Messages: This review will encompass the current literature regarding clinical safety and outcomes of these novel leadless pacemakers and discuss the evolving technologies in the field of cardiac pacing.
A 60-Year Literature Review on Hepatic Actinomycosis
Authors: Maraki Sofia , Mavromanolaki Viktoria Eirini , Stafylaki Dimitra , Anagnostopoulou Eliza , Moraitis Panagiotis , Kasimati Anna , Treptow Boris
Published: January 2022

Hepatic actinomycosis (HA) is a rare infection with an indolent course, atypical clinical manifestations, nonspecific laboratory and imaging findings, and challenging diagnosis. We describe a case of a 35-year-old female who developed HA 2 weeks after gastrectomy. In addition, we analyzed clinical characteristics and outcome of 157 additional cases of HA identified in a 60-year literature review. Patients with HA were predominantly male (57%) and more than one-half were between 40 and 70 years of age. The infection was cryptogenic in 80.8% of cases. Risk factors for HA were identified in 63.1% of the patients. Clinical presentation included fever (57.7%), abdominal pain (52.1%), weight loss (45.1%), anorexia (27.5%), fatigue and chills (12.7% each), and malaise (12%) over a 2.35 ± 3.5 months period. Leukocytosis, elevated alkaline phosphatase, erythrocyte sedimentation rate, and C-reactive protein were the most frequent laboratory findings. Radiologic imaging revealed that the right lobe was more frequently affected (62.5%) with a single lesion found in two-thirds of cases. Diagnosis was achieved by histopathologic examination in 70.6% of cases. Cultures yielded Actinomyces in 45 instances, with A. israelii being the most frequent species. Less than one-half of the patients were treated only with antibiotics, while the others received combined medical and surgical treatment. The median duration of antibiotic therapy was 135 days. The presence of multiple lesions or solid tumor-like lesions (without liquefaction) was significantly associated with medical therapy alone. The outcome was favorable in most cases (94%). Although rarely encountered, HA should be considered in patients with a chronic or subacute inflammatory process of the liver to promptly diagnose and treat.
The Absence of the Neuronal Component in Limited Dorsal Myeloschisis: A Case Report
Authors: Vrij Casper , Bouwens van der Vlis Tim , Tijssen Maud , Beckervordersandforth Jan , van Aalst Jasper
Published: January 2022

Introduction: The presence of neuroglial tissue is considered a hallmark in limited dorsal myeloschisis (LDM). However, several reports have indicated that the presence of neuroglial tissue in LDM cannot always be demonstrated. Here, we present such a case of LDM and provide an alternative hypothesis for lacking the neuronal component. Case Description: An antenatal LDM suspected neonate was born with a cystic skin lesion and membranous sac typical for membranous LDM. Three days postpartum the otherwise healthy infant underwent surgery, during which the stalk was resected and the spinal cord was untethered. Histopathologically, no neuroglial tissue could be determined. Noteworthy, S-100 staining revealed numerous peripheral nerves. Discussion: The current paradigm explains the absence of neuroglial tissue in resected stalks of LDM by indicating that it should be present in the unresected part, more proximal to the dorsal spinal cord. We hypothesize a different mechanism in which following reopening of the neural tube, mesodermal invasion causes a tight and persistent strand between the cutaneous- and neuroectoderm. Elongation of this mesodermal strand during embryological development allows for the formation of a mesenchymal stalk without the presence of neuroglial tissue. Hydrodynamic forces can cause fistulation of the poorly differentiated mesodermal tissue and subsequently lead to a saccular defect.
Fandom: cultura participativa em busca de um ídolo
Authors: Monteiro Camila
Published: January 2022

O presente trabalho tem como objetivo estudar o funcionamento dos chamados fandoms na internet, em especial os do reality show norte-americano American Idol e como eles refletem a convergência das mídias, inteligência coletiva, troca de capital social e remediação. Para o desenvolvimento da pesquisa foram estudados dois diferentes fandoms: o Idolforums e o ONTD_AI. Ambos são fóruns norte-americanos, abertos ao público para a discussão de assuntos referentes ao programa. Como os objetos de estudo são dois fandoms da internet que retratam um programa de TV cujo objetivo é encontrar um ídolo musical, a convergência de mídias juntamente com a cultura participativa (Jenkins, 2008) são carros-chefe deste trabalho
A Possibilidade de Responsabilização Civil de Terceiros por Comentários na Internet
Authors: Zago Gabriela da Silva
Published: January 2022

Com o advento da Internet, cada vez mais pessoas têm a oportunidade de expressar sua opinião através do ciberespaço. Mas ao mesmo tempo que se tem essa liberdade de se dizer o que se quer, também surge a necessidade de responsabilização pelo que se diz. Baseado nesse contexto, este trabalho propõe-se a analisar a possibilidade de responsabilização civil de terceiros por comentários publicados em espaços interativos na Internet. A pesquisa parte da ideia de que os blogs e os sites de relacionamento, enquanto espaços que permitem a livre manifestação de usuários, em regra sem controle editorial prévio e em tempo real, também são meios de comunicação cujas informações publicadas podem gerar atos ilícitos, que, por sua vez, levam à possibilidade de responsabilização civil
O Festival de Máscaras na Publicidade
Authors: Meneghetti Maria Eduarda Zorél , Bassi Mariana Travieso
Published: January 2022

O mundo fantástico da publicidade é colocado em discussão nesse artigo, cuja proposta fundamenta-se na compreensão do modo de articulação do discurso retórico – verbal e não-verbal - da publicidade como agente despertador da decepção do indivíduo. Essa reflexão analisa a utilização do humor e do software Adobe Photoshop em peças publicitárias de xampu destinadas ao público feminino como estratégias de comunicação susceptíveis de deflagrar decepção no consumidor
MARKETING DIGITAL DA ZOEIRA: A REPRODUÇÃO DOS MEMES EM PEÇAS PUBLICITÁRIAS PARA REDES SOCIAIS
Authors: Oliveira Gleiciane Rolin de , Goes Beatriz Silva
Published: January 2022

O presente artigo trata das estratégias do marketing digital em forma de zoeira, presentes em posts nas redes sociais. Busca-se analisar o uso de memes em peças publicitárias e as tendências do marketing digital nas redes sociais. Analisou-se os casos do Ovomaltine, envolvendo as marcas McDonald's, Bob’s, Burger King, Giraffas e Philips Walita e o caso da Friboi antes e depois da operação carne fraca. Conclui-se que apesar da zoeira, para que os memes se tornem peças-chave para a publicidade é necessário o bom senso e o uso da coerência as estratégias propostas pelo marketing digital no ambiente da internet.
construção das personagens femininas no cinema clássico mexicano
Authors: Benjamim Caleb
Published: January 2022

O presente trabalho tem a finalidade de propor uma leitura da construção das personagens femininas no Cinema Clássico Mexicano, mais especificamente nos filmes “Enamorada” (1946), de Índio Fernandez e “Susana” (1951), de Luís Buñuel. Através dos protótipos femininos categorizados por Silvia Oroz, e da ótica de Metz e Baudry acerca dos efeitos persuasivos produzidos pelo Cinema enquanto aparelho discursivo e narrativa, tenta-se mostrar como esses filmes serviam de veículo a uma mensagem manipulatória para manutenção de uma ideologia machista e patriarcal, herdada da era pré-revolução mexicana.
‘As crianças não podem saber de nada’
Authors: Sales Andressa Ribeiro , Doretto Juliana
Published: January 2022

Com base em entrevistas realizadas com meninos e meninas de menor rendimento e com faixa etária entre 10 e 12 anos, moradoras do bairro periférico, Jardim Orion, zona sul de São Paulo, este trabalho buscou compreender como se dá o consumo de notícias jornalísticas feito por elas, sobretudo na Internet e meios digitais. Entendemos que, assim como mostram outros trabalhos da área, as crianças têm consciência sobre o que é notícia jornalística e que seu consumo jornalístico é feito primeiramente na televisão, apesar de usarem a rede com frequência. Podemos perceber ainda que o jornalismo sensacionalista está presente da vida das crianças que moram na periferia de forma mais intensa do que nas classes mais altas, e isso tornou-se referência para elas no que diz respeito às notícias.
Cinema Novo e o sujeito negro - Zózimo Bulbul
Authors: Martins Kariny Felipe
Published: January 2022

Com o intuito de renovar a imagem cinematográfica, as representações sociaise raciais não passaram despercebidas pelo Cinema Novo. Filmes como Rio 40, graus (1955),de Nelson Pereira dos Santos, Barravento (1969), de Glauber Rocha, e Ganga Zumba (1963),de Carlos Diegues, levantaram questões raciais. Com crítica dura ao cinema industrial– em especial as chanchadas da Vera Cruz –, os cinemanovistas tenderam a observar asrepresentações dos negros em outros movimentos. Geralmente, estereotipados, os atorese as atrizes negras interpretavam personagens subalternos e secundários. Dentro destemovimento, surge Zózimo Bubul (diretor negro), iniciando a carreira como ator, encontrouno Cinema Novo a possibilidade de narrar o mundo a partir de si, ressignificando a imagemdo negro por ele próprio.
Digitalização do movimento corporal pelo uso de novas mídias interativas na arte
Authors: Oliveira Milena de
Published: January 2022

O estudo tem como objetivo falar sobre mídias contemporâneas e interativas na arte, tomando como base a história da representação do movimento corporal por meio de alguns aspectos interativos vindos de técnicas tradicionais nas artes visuais. Para isso, foi realizada uma revisão bibliográfica de autores influentes no tema e o estudo é teórico-crítico, pois também analisa produções de artistas contemporâneos como, por exemplo, Jeff Koons, Celina Portella, Christin Marczinzik e Thi Binh Minh Nguyen. Então o intuito é tentar entender como atualmente os movimentos corporais reais dos participantes são reconhecidos virtualmente ao ponto de conectar, através das sensações, o ambiente real com o virtual. Por meio disso, percebe-se uma aproximação cada vez mais íntima entre o participante e as obras elaboradas em ambientes virtuais que alteram a percepção do entorno e lidam com exigências corporais diferentes das usuais.
representação da nudez feminina em Game of Thrones:
Authors: Carboni Camille , Farias Larissa Bomfim Santana , Grohmann Rafael do Nascimento
Published: January 2022

Este artigo analisa como a nudez das personagens femininas é explorada na primeira e na quinta temporada do seriado Game of Thrones, da HBO, tendo como objetos de pesquisa os episódios nos quais aparecem as personagens Daenerys Targaryen e Cersei Lannister, protagonistas da série. Nosso objetivo é entender como as posições de poder ocupadas pelas personagens já citadas e a forma como seus corpos aparecem durante o seriado podem estar relacionadas, utilizando como base as teorias de Michel Foucault para mostrar que quanto maior o status de poder de uma personagem feminina, menos a nudez de seu corpo será explorada nas cenas, sendo o inverso da mesma maneira verdadeiro: quanto maior o estado de vulnerabilidade, mais exposto será o seu corpo em termos de nudez.
Quando a pauta é ciência: a percepção de jornalistas brasileiros sobre C&T
Authors: Simião Jhonatas Henrique , Figueiredo Simone Pallone de
Published: January 2022

Os desafios para a cobertura de qualidade de Ciência e Tecnologia (C&T) pela imprensa brasileira são inúmeros e passam por fatores diversos. No entanto, pouco foi explorado academicamente acerca da percepção e da visão de C&T desses profissionais, tidos como formadores de opinião na sociedade, objetivo proposto neste artigo. A pesquisa do tipo survey foi utilizada como suporte metodológico no trabalho, com as finalidades de descrição e exploração, através de questionário online autoaplicado com 26 perguntas, estimuladas e espontâneas, a uma amostra de 61 jornalistas, que representa 0,43% do universo de 14.017 profissionais estudados, ou seja, não se tem uma amostra representativa do grupo. Entretanto, os resultados da análise têm potencial de fornecer indicadores que auxiliem as redações jornalísticas no país e comunidade científica.
silêncio na estética audiovisual
Authors: Capato Giulia Torres , Fernandez Alexandre Marino
Published: January 2022

Neste artigo abordaremos o silêncio nos filmes A Vila de M. Night Shyamalan e A Chegada de Dennis Villeneuve. Em primeiro lugar faremos uma revisão bibliográfica sobre o uso do silêncio no audiovisual, apontando, também, caminhos alternativos que possam trazer alguma luz sobre o tema, para depois partir para a análise do silêncio nas obras citadas, estabelecendo relações com a bibliografia apresentada.
Subversões em Lavoura arcaica, de Luiz Fernando Carvalho
Authors: Gaze Felipe Nascimento , Alcantara Filho Wolmyr Aimberê
Published: January 2022

O artigo faz uma análise do filme Lavoura arcaica (2001), de Luiz Fernando Carvalho, baseado no romance homônimo de Raduan Nassar, de 1975. A primeira parte apresenta uma síntese da trama e aponta como a rebeldia do personagem André seria, ao final, uma subversão àquela estrutura familiar que busca em Horkheimer um entendimento da família como local de aparelhamento ideológico para manutenção do poder dominante na sociedade burguesa. A segunda parte recorre à teoria estética de Adorno, que entende que forma e estrutura social caminham juntas na obra de arte, para mostrar que a subversão em Lavoura arcaica vai além do conteúdo, repousando também na sua forma, algo próximo da narrativa não-linear da obra escrita.
A Agonia (Júlio Bressane, 1978) no cinema experimental brasileiro
Authors: Sousa Pedro Pimenta Barbosa de
Published: January 2022

Este trabalho tem como objetivo realizar uma análise da relação intertextual existente entre Limite (Mário Peixoto, 1931) e A Agonia (Júlio Bressane, 1978). Limite é um longa-metragem, de estilo experimental e que foi pouco visto até a década de 1970, quando a obra é restaurada e passa a ser mais disseminada. Júlio Bressane a assiste pela primeira vez nessa ocasião, e decide realizar um longa-metragem (A Agonia) com o intuito de realizar, nas palavras do diretor, uma "crítica cinematográfica" de Limite. A análise concentrou-se nas sequências de A Agonia que reencenam, em uma chave particular, trechos do filme de Mário Peixoto.
MASP entre Guerrilla Girls e 8M:
Authors: Cozzetti Giovanna Mendonça , Nibbering Lucas
Published: January 2022

O presente artigo se propõe a analisar as ações empreendidas pelo Museu de Arte de São Paulo no sentido de conceder maior espaço às narrativas femininas-feministas, a partir da Exposição das Guerrilla Girls, de 2017, até a ação do Dia Internacional da Mulher, #8M, em 2019. Ademais, também foi realizada uma análise com o objetivo de avaliar se o discurso inclusivo do museu está alinhado às práticas institucionais. Para tanto, foram levadas em consideração, além do Relatório Anual de atividades do MASP, produções teóricas de autores clássicos e, especialmente, de autoras do gênero feminino.
O jornalismo como responsável pelas fake news que ele não concebe
Authors: Kneipp Valquíria , Paiva Nínive Luara de Araújo
Published: January 2022

Com a veolcidade da informação em um mundo superconectado ocorre a potencialização das notícias falsas na sociedade. Esta pesquisa tem como objetivo investigar como o jornalismo contemporâneo vem combatendo as fake news. Com bases conceituais calcadas na proposta de Matthew D’Ancona (2018) de pós verdade, se buscou responder: como a checagem de fatos se caracteriza como uma ferramenta na preservação do acesso à informação e na confiança da atividade jornalística? Como objeto empírico foi selecionada a editoria UOL Confere do Portal de Notícias UOL. O instrumental metodológico contou com observação virtual, levantamento, catalogação e análise dos conteúdos checados por um mês, caracterizando como um estudo de caso.
A (des)estruturação de estereótipos de gênero na produção publicitária
Authors: Tonini Bruna Tecchio
Published: January 2022

O presente artigo busca analisar o modo como os afetos de consumo referentes aos gêneros são abordados nas retóricas publicitárias de anúncios contemporâneos que aspiram à desconstrução imagética das masculinidades ou feminilidades estereotipadas. Para isso, analisamos três diferentes anúncios publicitários a partir da metodologia Análise do Discurso de linha francesa, a qual objetiva mapear e investigar as estratégias discursivas e os discursos mediados. Com isso, o projeto propõe-se a estudar as formas com que a publicidade atua ao questionar padrões de gênero e quais são as consequências geradas no contexto sociocultural em termos políticos de visibilidade e reconhecimento sobre o tema.
Padrões de comportamento sob a ótica da cultura de fãs: espectadores e fãs brasileiros da animação Irmão do Jorel
Authors: Bona Rafael Jose , Guerra Bianca Katherine Plebani , Schlögl Larissa
Published: January 2022

Este artigo objetiva analisar o perfil e o comportamento dos espectadores brasileiros da animação Irmão do Jorel por meio de teorias relacionadas à cultura de fãs. Por meio de uma pesquisa aplicada com 502 fãs da animação, foram abordadas as seguintes dimensões: níveis de identificação, engajamento, confiança, interesse, classificação como fã, níveis de paixões e motivações. Os resultados demonstram que a maioria dos espectadores assiste por motivos mais profundos, que estão ligados a uma felicidade eudaimônica, inconscientemente ou não, e, simultaneamente, por motivos rasos e baseados em uma felicidade hedonista. Quase metade dos espectadores do desenho são fãs e a maioria tem um nível harmonioso de paixão por ele. Os fãs são pouco engajados na internet, têm pouca confiança em outros fãs, mas possuem muito interesse em adquirir produtos comerciais e buscar informações sobre o desenho.
A cobertura Jornalística do PerifaCon: uma análise dos textos e imagens em diferentes sites
Authors: Silva Gabriela Cristina da
Published: January 2022

Este artigo aborda como o evento cultural PerifaCon foi tematizado por diferentes sites. Busca-se analisar o uso das teorias do jornalismo, como a teoria do enquadramento, a teoria organizacional, os gêneros e formatos jornalísticos e as linguagens conotativa e denotativa estão presentes nos conteúdos publicados pelos veículos: G1, Estadão, Omelete, Ponte Jornalismo e Agência Mural. Para isso, foram analisadas as matérias publicadas entre 16 de janeiro de 2019 e 17 de abril de 2020 sobre o evento, além dos textos de matérias publicadas entre os dias 19 e 25 de março de 2019. As conclusões mostram que as teorias apresentadas influenciam no modo em que cada veículo apresenta o PerifaCon.
Vogue, logo, existo: A comunicação política-corporificada da Ballroom
Authors: Estevam Aleson Lima Gomes , Geraldes Elen
Published: January 2022

Este artigo busca debater condições para uma comunicação subversiva de normas hegemônicas presentes na sociedade, tentando responder à questão: Como os corpos dos e das participantes da cultura Ballroom se comunicam? Ao utilizar os recursos metodológicos da entrevista em profundidade e com o aporte teórico de Judith Butler, Hannah Arendt, Jesús Martín-Barbero e Roque Laraia, conclui-se que, nessa cultura, há um corpo comunicativo político. Pensar Ballroom é pensar em falas corpóreas que demandam seus locais de direito.
Four new species of the primitively segmented spider genus Songthela (Mesothelae, Liphistiidae) from Chongqing Municipality, China
Authors: CHEN ZHAOYANG , LIU FENGXIANG , LI DAIQIN , XU XIN
Published: January 2022

This paper reports four new species of the primitively segmented spider genus Songthela from Chongqing Municipality, China, based on morphological characters of both males and females: S. jinyun sp. nov., S. longbao sp. nov., S. serriformis sp. nov. and S. wangerbao sp. nov. We also provide the GenBank accession codes of mitochondrial DNA barcode gene, cytochrome c oxidase subunit I (COI), for the holotype of four new species for future identification.
A new species of Mecophilus (Geophilidae: Aphilodontinae), with the first report of the genus from the state of Rio de Janeiro, Brazil
Authors: CALVANESE VICTOR C. , BRESCOVIT ANTONIO D.
Published: January 2022

Mecophilus carioca n. sp. is described based on males and females recently sampled in the Parque Nacional de Itatiaia, and is the first record of the genus from the state of Rio de Janeiro, Brazil. The specimens were analyzed in both light microscopy and scanning electron microscopy, and photos and schematic illustrations are provided. The known distribution of the three species of Mecophilus are presented in a map.
A flexible, lightweight and stretchable all-solid-state supercapacitor based on warp-knitted stainless-steel mesh for wearable electronics
Authors: Su Chuanli , Shao Guangwei , Yu Qinghua , Huang Yaoli , Jiang Jinhua , Shao Huiqi , Chen Nanliang
Published: January 2022

Highly conductive, flexible, stretchable and lightweight electrode substrates are essential to meet the future demand on supercapacitors for wearable electronics. However, it is difficult to achieve the above characteristics simultaneously. In this study, ultrafine stainless-steel fibers (with a diameter of ≈30 μm) are knitted into stainless-steel meshes (SSMs) with a diamond structure for the fabrication of textile stretchable electrodes and current collectors. The electrodes are fabricated by utilizing an electrodeposited three-dimensional network graphene framework and poly(3,4-ethylenedioxythiophene) (PEDOT) coating on the SSM substrates via a two-step electrodeposition process, which show a specific capacitance of 77.09 F g−1 (0.14 A g−1) and superb cycling stability (91% capacitance retention after 5000 cycles). Furthermore, the assembled flexible stretchable supercapacitor based on the PEDOT/reduced graphene oxide (RGO)@SSM electrodes exhibits an areal capacitance (53 mF cm−2 at 0.1 mA cm−2), a good cycling stability (≈73% capacitance retention after 5000 cycles), rate capability (36 mF cm−2 at 5 mA cm−2), stretchable stability (≈78% capacitance retention at 10% strain for 500 stretching cycles) and outstanding flexibility and stability under various bending deformations. The assembled supercapacitors can illuminate a thermometer and a light-emitting diode, demonstrating their potential application as stretchable supercapacitors. This simple and low-cost method developed for fabricating lightweight, stretchable and stable high-performance supercapacitors offers new opportunities for future stretchable electronic devices.