bluuebunny/crossref_metadata_2025 huggingface dataset:
RELIGIOUSNESS AND HEALTH SUPPORT ISSUES FROM THE STANDPOINT OF CONTEMPORARY STUDENT YOUTH
Authors:   Vladimir Branch of the Russian Academy of National Economy and Public Administration under the President of the Russian Federation, Vladimir, Russian Federation, PETROSYAN  DMITRY , SHADRINA OLGA ,   Alexander Grigorievich and Nikolai Grigorievich Stoletov Vladimir State University,   Northern State Medical University of the Ministry of Healthcare of the Russian Federation, Arkhangelsk, Russian Federation
Published: January 2023

The article provides the findings of an empirical research into the correlation between religiousness of student youth in the city of Vladimir and its attitude towards their health through the spectacle of religious studies. The poll was conducted in April 2022 by means of a questionnaire survey among the students of higher education institutions in Vladimir. The overall sample comprised 509 respondents. The subject matter of the research is a specific nature of correlation between students’ understanding of their own religiousness and their views towards the importance of a healthy lifestyle. For the purposes of analysis, the students were divided into three identification groups depending on their self-identity: “believers”, “non-believers”, and “persons in doubt”, amounting to 23.4, 26.2 and 50.4%, respectively. The findings demonstrate that more than a half (52.3%) of students completely agree that one shall take a medicine only by prescription and that it is important to undergo preventive medical examinations (59.3%). The findings also reveal the impact of religious self-identity on the self-assessment of students’ health. There are considerably more those agreeing that they are absolutely healthy among the “believers” when compared to the “persons in doubt”, and especially to the “non-believers”. The overwhelming majority of students agree that “disease is a natural event caused by viruses or microorganisms” rather than a “punishment for one’s sins”. Further activities aimed at the development of rational approaches preconditioning young people’s willingness to protect their own health might become an effective mechanism allowing for congruent behavior with a focus on preservation and strengthening of a person’s well-being.
IDENTIFICATION ALGORITHM FACES AND CRIMINAL ACTIONS
Authors:   Russian Technological University MIREA, Moscow, Russian Federation, HADI  NAMIR MOHAMED
Published: January 2023

Currently, there are a number of unresolved problems in the identification of images. If a person is wearing something on their face, such as a mask or glasses, or at some point part of the face is covered by clothing, hair or an object, then the video surveillance system may lose sight of the person. Identification deteriorates significantly, and recognition of a person occurs only after some time. The purpose of this work is to improve the existing methods of recognition. The paper proposes an algorithm based on the multi-cascade method and the object detection method. This algorithm is able to identify a person by the actions of a criminal nature and by the face by highlighting some parts of the face in the form of squares and rectangles using the computer vision library. As a result of testing, the algorithm showed high detection accuracy using a GPU with 16 GB of video memory.
DEVELOPMENT OF A METHOD FOR OBTAINING CERAMIC NANOCOMPOSITES USING SOL-GEL TECHNOLOGY ELEMENTS TO CREATE INCLUSIONS OF AMORPHOUS PHASES WITH A COMPOSITION SIMILAR TO THE TARGET CRYSTALLINE CERAMIC MATRIX
Authors:   Institute of Materials Science of the SPA “Physics-Sun” of the Academy of Science of Uzbekistan, Tashkent, Republic of Uzbekistan, RAKHIMOV  RUSTAM , PANKOV  VLADIMIR , YERMAKOV  VLADIMIR , HAIDUK  YULYAN , RAKHIMOV  MUROD , MUKHTOROV  DILMUROD ,   Belarusian State University, Minsk, Republic of Belarus,    Fergana Polytechnic Institute, Fergana, Republic of Uzbekistan
Published: January 2023

A method has been developed for obtaining ceramic nanocomposites using elements of sol-gel technology to create inclusions of amorphous phases with a composition similar to the target crystalline ceramic matrix synthesized in a solar furnace. It is shown that when the resulting material is activated by pulses generated by functional ceramics, the properties of this material approach those of the prototype. The use of this development can lead to the possibility of producing a film-ceramic composite in industrial volumes and at a low cost.
Perceptions of Body Image of Women with Blindness
Authors: Csernák Edina , Gombás Judit
Published: January 2023

Introduction: Body dissatisfaction is a general concern from teenage years onwards, and is especially characteristic in the population of young women all over the world.
Objectives: This qualitative research sought to find answers to how young (aged 18-30) women with congenital or acquired blindness perceive their body image (BI), and how they get information about the appearance of others.
Methods: Semi-structured interviews were conducted with twelve blind women, aged 18-30 years. Verbatim interview transcripts were analysed independently by both first and second author, following guidelines of constructivist grounded theory (CGT). Coding was conducted in accordance with Strauss and Corbin’s (1998) procedure: transcripts were analysed with open, axial and finally with selective coding.
Results: Findings confirm that feedback from important others, especially negative feedback, greatly influences young women with blindness in developing their BI, and that for many it is a concern to what extent they should internalise negative remarks which are related to their appearance.
Conclusion: Since feedback and verbal information from others are essential for women with blindness in trying to understand what they and others look like, it is important for professionals, parents and for the women themselves to understand how vulnerable they may be to the criticism of others.
Científicos en redes sociales. Divulgación y curación de contenidos en twitter: taxonomía y casos
Authors: Gil Lydia , Guallar Javier
Published: January 2023

El objetivo de este trabajo es ofrecer una primera aproximación al uso por parte de investigadores de la curación de contenido en sus publicaciones en redes sociales, en concreto, en hilos de Twitter. Se ha realizado un estudio cualitativo exploratorio en el que se presenta una taxonomía para el análisis de la curación de contenido en los hilos de Twitter de divulgación científica publicados por investigadores. La taxonomía propuesta se basa en los parámetros, agrupados bajo las dimensiones de Contenido y de Curación, de: Cantidad de contenidos, Rango temporal de los contenidos, Procedencia de los contenidos, Técnicas de curación e Integración de la curación. Los resultados muestran la viabilidad de este esquema mediante casos extraídos de publicaciones en hilos de Twitter de investigadores pertenecientes a variadas disciplinas y con representatividad de género. Se considera que esta taxonomía puede ser de utilidad, no solo para estudiosos y profesionales de la curación de contenido, sino también, y muy especialmente, para la propia comunidad científica de investigadores y divulgadores cuando publican en redes sociales.
Viruela del Mono (Mpox): Aspectos Clínicos y Terapéuticos
Authors: Maguiña-Vargas Ciro , Espinal-Ramírez Michell
Published: January 2023

Desde la aparición de la viruela del mono (Mpox) en el humano en África en 1970 y posteriormente hacerse endémico, en los pacientes afectados se ha descrito un comportamiento denominado clásico caracterizado por tener síntomas iniciales como fiebre, cefalea, mialgias, linfoadenomegalia; luego de algunos días, se produce la aparición de lesiones eruptivas de tipo papulares, vesiculares, pustulares, algunas ulcerativas hasta la formación de costras afectando cara manos y pies, todas en el mismo estadio, su número variaba de cientos a miles; en cambio, este nuevo brote de Mpox que apareció en mayo de 2022, es algo diferente a nivel clínico, muchos pacientes con lesiones eruptivas no tienen muchos síntomas prodrómicos, las lesiones cutáneas aparecen en menor número y en áreas no descritas como la zona ano genital; asimismo, a las complicaciones descritas en África, en esta nueva epidemia se han añadido otros como proctitis, proctocolitis, etc. Además, el grupo más afectado hoy en día es la población que tiene HSH y bisexuales, en especial el grupo que padece VIH.
Viruela del Mono: Medidas de Prevención y Control (Experiencia del Brasil)
Authors: Cortez-Escalante Juan , Maguiña-Vargas Ciro
Published: January 2023

Desde que la viruela símica (Mpox) es declarada como Emergencia de Salud Pública de Importancia Internacional (ESPII) por la OMS diversas medidas han sido implementadas en todos los países que han confirmado casos, con énfasis en las medidas de Prevención y Control de la Infección (PCI) que tienen por objetivo evitar la diseminación del Mpox, entre las que podemos destacar la implementación de medidas de precaución estándar, de contacto, para gotas respiratorias y aerosoles para cualquier paciente sospechoso o confirmado de Mpox; al realizar procedimientos que produzcan aerosoles los profesionales de salud deben utilizar las mascarilla N95/PFF2 y debe ser realizado en local apropiado; las áreas dentro del establecimiento de salud que el paciente usa con frecuencia o donde se llevan a cabo las actividades de atención al paciente y los equipos utilizados con el paciente deben limpiarse y desinfectarse siguiendo las pautas nacionales o del establecimiento de salud; la ropa de cama, batas de hospital, toallas y cualquier otro artículo de tela debe manipularse y recogerse con cuidado; todos los fluidos corporales y los desechos sólidos de los pacientes con Mpox deben tratarse como desechos infecciosos; y los pacientes aislados con Mpox deben seguir medidas para apoyar su interacción con los familiares y visitantes para promover su bienestar. También hay que considerar medidas especiales para las gestantes, puérperas y recién nacidos, afín de evitar la transmisión de este virus.
Cirugía laparoscópica vs Lichtenstein modificada en pacientes operados de hernia inguinal no complicada en el Hospital Carlos Alcántara Butterfield entre los meses noviembre 2015 y febrero 2019
Authors: Gálvez-Mideiros Victor , Rivera-Vergara Andrea , Gálvez-Alarcón Diego
Published: January 2023

El propósito de este estudio fue comparar los resultados de la cirugía de reparación de hernia inguinal no complicada usando dos distintas técnicas: Técnica laparoscópica y Lichtenstein modificada. Métodos: En este estudio observacional descriptivo retrospectivo se incluyeron 307 pacientes operados de hernia inguinal no complicada en el Hospital Carlos Alcántara Butterfield entre noviembre 2015 y febrero 2019, de los cuales 201 fueron operados con técnica Lichtenstein y 106 con técnica laparoscópica. Como resultados primarios se tomaron en cuenta la recidiva y el dolor crónico, considerándolos en su conjunto como complicaciones tardías; y como resultados secundarios se incluyeron las complicaciones a corto plazo: dolor agudo, seroma, hematoma, quiste de cordón, infección de herida operatoria, orcoepididimitis e hidrocele. Resultados: De los 307 pacientes que se sometieron a reparación de hernia inguinal, 201 fueron operados con la técnica de Lichtenstein y 106 pacientes fueron operados con cirugía laparoscópica. Se les realizó seguimiento entre 1.07 y 5.5 años. En cuanto a los resultados principales se observó que el tipo de cirugía laparoscópica representaba 87% menor frecuencia de complicaciones tardías, en comparación con operados bajo cirugía tipo Lichtenstein (RP=0.13, IC95%: 0.03-0.71). No se encontró diferencia estadísticamente significativa entre la cirugía laparoscópica y Lichtenstein en relación a los resultados secundarios.
Bioprospecting Indigenous Marine Microalgae for Polyunsaturated Fatty Acids Under Different Media Conditions
Authors: Jain Priyanshu , Minhas Amritpreet Kaur , Shukla Sadhana , Puri Munish , Barrow Colin J. , Mandal Shovon
Published: January 2023

Marine microalgae produce a number of valuable compounds that have significant roles in the pharmaceutical, biomedical, nutraceutical, and food industries. Although there are numerous microalgal germplasms available in the marine ecosystem, only a small number of strains have been recognized for their commercial potential. In this study, several indigenous microalgal strains were isolated from the coast of the Arabian Sea for exploring the presence and production of high-value compounds such as polyunsaturated fatty acids (PUFAs). PUFAs are essential fatty acids with multiple health benefits. Based on their high PUFA content, two isolated strains were identified by ITS sequencing and selected for further studies to enhance PUFAs. From molecular analysis, it was found both the strains were green microalgae: one of them was a Chlorella sp., while the other was a Planophila sp. The two isolated strains, together with a control strain known for yielding high levels of PUFAs, Nannochloropsis oculata, were grown in three different nutrient media for PUFA augmentation. The relative content of α-linolenic acid (ALA) as a percentage of total fatty acids reached a maximum of 50, 36, and 50%, respectively, in Chlorella sp., Planophila sp., and N. oculata. To the best of our knowledge, this is the first study in exploring fatty acids in Planophila sp. The obtained results showed a higher PUFA content, particularly α-linolenic acid at low nutrients in media.
The Production of Fat-Containing Cultured Meat by Stacking Aligned Muscle Layers and Adipose Layers Formed From Gelatin-Soymilk Scaffold
Authors: Li Chi-Han , Yang I-Hsuan , Ke Cherng-Jyh , Chi Chih-Ying , Matahum Jefunnie , Kuan Che-Yung , Celikkin Nehar , Swieszkowski Wojciech , Lin Feng-Huei
Published: January 2023

Graphical Abstract

Scheme for cultured meat preparation (A) Gelatin–soymilk solution is prepared and then put on the PDMS mold to prepare a GS scaffold with parallel microchannels. (B) The C2C12 myoblasts and 3T3-L1 pre-adipocytes are seeded on the GS scaffold to prepare adipocyte-topped muscle-like layers and adipose-like layers. (C) The two layers are then stacked layer by layer to assemble into cultured meat containing fat.
Preparation of Novel ICT-CMC-CD59sp Drug-Loaded Microspheres and Targeting Anti-Tumor Effect on Oral Squamous Cell Carcinoma
Authors: Gao Xiang , Wang Wanchun , Gao Meihua
Published: January 2023

The treatment of oral squamous cell carcinoma (OSCC) remains a great clinical challenge, and the malignant proliferation of OSCC cells can lead to the overexpression of CD59. In this study, a novel microsphere (ICT-CMC-CD59sp) composed of icariin (ICT), carboxymethyl chitosan (CMC), and cell differentiation antigen 59-specific ligand peptide (CD59sp) was successfully prepared by using the emulsion cross-linking method. Through the guidance of CD59sp, the microspheres can target OSCC cells and play a therapeutic role (p < 0.01). The MTT test and trypan blue staining showed that the microspheres could promote the apoptosis of oral squamous cell carcinoma and had a significant difference (p < 0.01). In this study, the regulatory effect of the microspheres on OSCC cells was investigated at the cellular level, and its therapeutic effect on OSCC was discussed, which provided a new perspective for the targeted therapy of OSCC.
CD73-Positive Small Extracellular Vesicles Derived From Umbilical Cord Mesenchymal Stem Cells Promote the Proliferation and Migration of Pediatric Urethral Smooth Muscle Cells Through Adenosine Pathway
Authors: Zhang Shilin , Li Jierong , Li Chunjing , Xie Xumin , He Jun , Ling Fengsheng , Li Bowei , Wu Huayan , Li Zhilin , Zheng Jianwei
Published: January 2023

Smooth muscle cells (SMCs) are the main functional component of urethral tissue, but are difficult to proliferate in vitro. Mesenchymal stem cells (MSCs) and mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) have been shown to promote tissue repair by regulating the proliferation and migration of different types of cells. In this study, we investigated the effect of umbilical cord mesenchymal stem cell-derived sEV (UCMSC-sEV) on the proliferation and migration of pediatric urethral smooth muscle cells (PUSMCs) and the mechanism by which sEV regulates the function of PUSMCs. We observed that UCMSC-sEV can significantly promote the proliferation and migration of PUSMCs in vitro. UCMSC-sEV exerted proliferation and migration promotion effects by carrying the CD73 to PUSMCs and catalyzing the production of adenosine. Conversely, the effect of UCMSC-sEV on the proliferation and migration of PUSMCs were no longer observed with addition of the PSB12379 as a CD73 inhibitor. It was found that the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway in PUSMCs was activated by adenosine or UCMSC-sEV intervention. In summary, UCMSC-sEV promoted proliferation and migration of PUSMCs in vitro by activating CD73/adenosine signaling axis and downstream PI3K/AKT pathway. Thus, we concluded that UCMSC-sEV may be suggested as a new solution strategy for the urethral tissue repair.
Evaluation of photogrammetry for medical application in cardiology
Authors: Talevi Giacomo , Pannone Luigi , Monaco Cinzia , Bori Edoardo , Cappello Ida Anna , Candelari Mara , Wyns Manon , Ramak Robbert , La Meir Mark , Gharaviri Ali , Chierchia Gian Battista , Innocenti Bernardo , de Asmundis Carlo
Published: January 2023

Background: In the field of medicine, photogrammetry has played for long time a marginal role due to the significant amount of work required that made it impractical for an extended medical use. Developments in digital photogrammetry occurred in the recent years, that have steadily increased the interest and application of this technique. The present study aims to compare photogrammetry reconstruction of heart with computed tomography (CT) as a reference.

Methods: The photogrammetric reconstructions of digital images from ECG imaging derived images were performed. In particular, the ventricles of 15 patients with Brugada syndrome were reconstructed by using the free Zephyr Lite software. In order to evaluate the accuracy of the technique, measurements on the reconstructions were compared to patient-specific CT scan imported in ECG imaging software UZBCIT.

Result: The results showed that digital photogrammetry in the context of ventricle reconstruction is feasible. The photogrammetric derived measurements of ventricles were not statistically different from CT scan measurements. Furthermore, the analysis showed high correlation of photogrammetry reconstructions with CT scan and a correlation coefficient close to 1.

Conclusion: It is possible to reproduce digital objects by photogrammetry if the process described in this study is performed. The reconstruction of the ventricles from CT scan was very close to the values of the respective photogrammetric reconstruction.
High throughput screening of key functional strains based on improving tobacco quality and mixed fermentation
Authors: Wen Cai , Zhang Qianying , Zhu Pengcheng , Hu Wanrong , Jia Yun , Yang Shuanghong , Huang Yang , Yang Zhen , Chai Zhishun , Zhai Tianyuan , Cao Yu , Li Dongliang
Published: January 2023

Background: Tobacco alcoholization is an important step in increasing the quality of tobacco leaf, which may convert a portion of low-grade tobacco leaves into useable product, however this may take to 2–3 years. The addition of exogenous microorganisms to tobacco leaves and treating them by biological fermentation can shorten the maturation time of tobacco leaves, and improve the quality and applicability of low-grade tobacco leaves

Methods: Several strains were screened from low-grade tobacco by flow cytometry, including the bacteria Bacillus amyloliticus, with starch degradation ability and Bacillus kochii, with protein degradation ability, and the fungus Filobasidium magnum with lipid oxidase ability, and were inoculated onto tobacco leaves, both individually and in combination, for solid-state fermentation

Results: The greatest improvement in tobacco quality was observed when strains 4# and 3# were applied at a ratio of 3:1. The Maillard reaction products, such as 2-amyl furan, 1-(2-furanmethyl) -1 h-pyrrole, furfural and 2, 5-dimethylpyrazine, were significantly increased, by up to more than 2 times. When strains F7# and 3# were mixed at a ratio of 3:1, the improvement of sensory evaluation index was better than that of pure cultures. The increase of 3-(3, 4-dihydro-2h-pyrro-5-yl) pyridine, β -damasone and benzyl alcohol was more than 1 times. The increase of 2-amyl-furan was particularly significant, up to 20 times

Conclusion: The functional strains screened from tobacco leaves were utilized for the biological fermentation of tobacco leaves, resulting in the reduction of irritation and an improvement in quality of final product, showing a good potential for application.
Smart citizen in architecture and landscape. Method design based on spatial intelligence and universal accessibility learning by students with intellectual disabilities
Authors: Cantarero-García Guadalupe , Mollá Marina , González-Lezcano Roberto Alonso
Published: January 2023

The Smart Citizen concept is at an early stage of research in the field of architecture and landscape architecture. ICTs and their use by citizens have been studied exclusively in the fields of engineering and telecommunications sciences as well as Artificial Intelligence. This study seeks to publicize the Smart Citizen concept in architecture and landscape from a spatial understanding and the perception of citizens with intellectual disabilities. A real case study developed by architects in collaboration with psychologists focused on the development of spatial intelligence for people with intellectual disabilities is presented in this study. “The students that participated in these activities belong to San Pablo CEU University course financed by ONCE Foundation (FONCE) and the European Social Fund.” The purpose is to question the effectiveness of the use of technologies for said cognitive development and how even the increased use of GPS navigator systems could be a detriment to the citizen when trying to orient him or herself in open spaces. The result to highlight in this review is to know if a person with a disability is equally capable of understanding a space and navigate it without the aid of GPS as a person without an intellectual disability. Both analogical tools (2D plan) and digital tools (GPS) are used under the same conditions. New lines of research are presented in the study of spatial intelligence through innovating tools or TICs in relation to urban elements where concepts like scale, proportion, light, and shade were identified.
Transitions of motor neuron activities during Ciona development
Authors: Utsumi Madoka K. , Oka Kotaro , Hotta Kohji
Published: January 2023

Motor neurons (MNs) are one of the most important components of Central Pattern Generators (CPG) in vertebrates (Brown, Proceedings of The Royal Society B: Biological Sciences (The Royal Society), 1911, 84(572), 308–319). However, it is unclear how the neural activities of these components develop during their embryogenesis. Our previous study revealed that in Ciona robusta (Ciona intestinalis type A), a model organism with a simple neural circuit, a single pair of MNs (MN2L/MN2R) was determining the rhythm of its spontaneous early motor behavior (developmental stage St.22-24). MN2s are known to be one of the main components of Ciona CPG, though the neural activities of MN2s in the later larval period (St.25-) were not yet investigated. In this study, we investigated the neural activities of MN2s during their later stages and how they are related to Ciona’s swimming CPG. Long-term simultaneous Ca2+ imaging of both MN2s with GCaMP6s/f (St.22-34) revealed that MN2s continued to determine the rhythm of motor behavior even in their later larval stages. Their activities were classified into seven phases (I-VII) depending on the interval and the synchronicity of MN2L and MN2R Ca2+ transients. Initially, each MN2 oscillates sporadically (I). As they develop into swimming larvae, they gradually oscillate at a constant interval (II-III), then start to synchronize (IV) and fully synchronize (V). Intervals become longer (VI) and sporadic again during the tail aggression period (VII). Interestingly, 76% of the embryos started to oscillate from MN2R. In addition, independent photostimulations on left and right MN2s were conducted. This is the first report of the live imaging of neural activities in Ciona’s developing swimming CPG. These findings will help to understand the development of motor neuron circuits in chordate animals.
Protein translation paradox: Implications in translational regulation of aging
Authors: Kim Harper S. , Pickering Andrew M.
Published: January 2023

Protein translation is an essential cellular process playing key roles in growth and development. Protein translation declines over the course of age in multiple animal species, including nematodes, fruit flies, mice, rats, and even humans. In all these species, protein translation transiently peaks in early adulthood with a subsequent drop over the course of age. Conversely, lifelong reductions in protein translation have been found to extend lifespan and healthspan in multiple animal models. These findings raise the protein synthesis paradox: age-related declines in protein synthesis should be detrimental, but life-long reductions in protein translation paradoxically slow down aging and prolong lifespan. This article discusses the nature of this paradox and complies an extensive body of work demonstrating protein translation as a modulator of lifespan and healthspan.
Rational design of potent ultrashort antimicrobial peptides with programmable assembly into nanostructured hydrogels
Authors: Cardoso Priscila , Appiah Danso Samuel , Hung Andrew , Dekiwadia Chaitali , Pradhan Nimish , Strachan Jamie , McDonald Brody , Firipis Kate , White Jacinta F. , Aburto-Medina Arturo , Conn Charlotte E. , Valéry Céline
Published: January 2023

Microbial resistance to common antibiotics is threatening to cause the next pandemic crisis. In this context, antimicrobial peptides (AMPs) are receiving increased attention as an alternative approach to the traditional small molecule antibiotics. Here, we report the bi-functional rational design of Fmoc-peptides as both antimicrobial and hydrogelator substances. The tetrapeptide Fmoc-WWRR-NH2—termed Priscilicidin—was rationally designed for antimicrobial activity and molecular self-assembly into nanostructured hydrogels. Molecular dynamics simulations predicted Priscilicidin to assemble in water into small oligomers and nanofibrils, through a balance of aromatic stacking, amphiphilicity and electrostatic repulsion. Antimicrobial activity prediction databases supported a strong antimicrobial motif via sequence analogy. Experimentally, this ultrashort sequence showed a remarkable hydrogel forming capacity, combined to a potent antibacterial and antifungal activity, including against multidrug resistant strains. Using a set of biophysical and microbiology techniques, the peptide was shown to self-assemble into viscoelastic hydrogels, as a result of assembly into nanostructured hexagonal mesophases. To further test the molecular design approach, the Priscilicidin sequence was modified to include a proline turn—Fmoc-WPWRR-NH2, termed P-Priscilicidin–expected to disrupt the supramolecular assembly into nanofibrils, while predicted to retain antimicrobial activity. Experiments showed P-Priscilicidin self-assembly to be effectively hindered by the presence of a proline turn, resulting in liquid samples of low viscosity. However, assembly into small oligomers and nanofibril precursors were evidenced. Our results augur well for fast, adaptable, and cost-efficient antimicrobial peptide design with programmable physicochemical properties.
Bibliometric evaluation of 2020–2022 publications on COVID-19-related cardiovascular disease
Authors: Chen Yiru , Cao Buzi , Zhou Quan , Liu Yantong , He Qingnan , Zhao Mingyi
Published: January 2023

Objective

This study aimed to investigate the international scientific output regarding the relationship between COVID-19 and cardiovascular diseases (CVDs) through a bibliometric analysis and explore research hotspots in this field.

Methods

We searched the Web of Science Core Collection for publications and used different types of software, such as R, CiteSpace, and VOSviewer, to analyze and visualize the data.

Results

A total of 10,055 publications were retrieved as of the 13 December 2022, based on the inclusion criteria after screening. The USA and China lead in the quantity and quality of publications in this field. Based on Bradford's law, 63 journals were considered core journals in the field. Co-cited references and keywords analysis indicated that researchers paid particular attention to cardiovascular comorbidities, outcomes, and COVID-19 regenerative medicine. In summary, with increasing COVID-19 research related to CVD, more attention might be drawn to the relationship between these two diseases.

Conclusion

The hotspots in this field may continue to revolve around cardiovascular comorbidities, outcomes, and COVID-19 regenerative medicine. Owing to the different situations faced by different groups with COVID-19, further exploration of the related factors specific to each of these groups, e.g., history or no history of heart failure, is needed, with a view to providing a reference for intervention measures in COVID-19 research.
Identification of early cardiac dysfunction and heterogeneity after pressure and volume overload in mice by high-frequency echocardiographic strain imaging
Authors: Xu Ran , Ding Zhiwen , Li Hao , Shi Jing , Cheng Leilei , Xu Huixiong , Wu Jian , Zou Yunzeng
Published: January 2023

Object

Aortic stenosis and regurgitation are clinically important conditions characterized with different hypertrophic types induced by pressure or volume overload, respectively, but with comparable cardiac function in compensated stage. Speckle-tracking based strain imaging has been applied to assess subtle alterations in cardiac abnormality, but its application in differentiating these two types of ventricular hypertrophy is still sparse. Here, we performed strain imaging analysis of cardiac remodeling in these two loading conditions.

Methods

C57BL/6J mice were subjected to transverse aortic constriction (TAC)-induced pressure overload or aortic regurgitation (AR)-induced volume overload. Conventional echocardiography and strain imaging were comprehensively assessed to detect stimulus-specific alterations in TAC and AR hearts.

Results

Conventional echocardiography did not detect significant changes in left ventricular systolic (ejection fraction and fractional shortening) and diastolic (E/E’) function in either TAC or AR mice. On the contrary, global strain analysis revealed global longitudinal strain and strain rate were remarkably impaired in TAC while preserved in AR mice, although global radial, and circumferential strain and strain rate were significantly reduced in both models. Regional strain analysis in the long axis demonstrated that longitudinal strain and strain rate in all or most segments were decreased in TAC but maintained or slightly dented in AR mice, while radial strain and strain rate indicated overt decline in both models. Moreover, decreased radial and circumferential strain and strain rate were observed in most segments of TAC and AR mice in the short axis.

Conclusion

Strain imaging is superior to conventional echocardiography to detect subtle changes in myocardial deformation, with longitudinal strain and strain rate indicating distinct functional changes in pressure versus volume overload myocardial hypertrophy, making it potentially an advanced approach for early detection and differential diagnosis of cardiac dysfunction.
Relationship between serum sodium levels and all-cause mortality in congestive heart failure patients: A retrospective cohort study based on the Mimic-III database
Authors: Peng Shixuan , Peng Jianxing , Yang Lianju , Ke Weiqi
Published: January 2023

Background

The relationship between serum sodium levels and mortality in congestive heart failure (CHF) patients has not been well-studied previously. The non-linear correlation between serum sodium levels and mortality in patients with heart failure is currently controversial, and the relationship between different serum sodium levels and mortality is disputed. The goal of this study is to look into the relationship between serum sodium levels and all-cause mortality in people with CHF after controlling for other factors.

Methods

The publicly accessible Mimic III database was the source of data for our study. We use the ICU Admission Scoring System to collect demographic data, laboratory findings, comorbidities, vital signs, and scoring information for each patient. Cox proportional risk analysis, smooth curve fitting, and the Kaplan-Meier survival curve were used to assess the relationship between baseline sodium levels and all-cause mortality in CHF patients.

Results

The segmentation regression model discovered a turning point value of serum sodium levels (137.5 mmol/L) between serum sodium levels and all-cause mortality. According to the results of the fully adjusted Cox proportional hazard model, lower serum sodium levels (<137.5 mmol/L) were associated with an increased risk of 30, 90, 365-day, and 4-year all-cause deaths. The HRs and 95th confidence intervals were 0.96 (0.94, 0.99), 0.96 (0.94, 0.99), 0.96 (0.94, 0.98), and 0.96 (0.95, 0.98), respectively; the higher serum sodium levels (≥137.5 mmol/L) were related to an associated multiplied risk of 30, 90, 365-day, and 4-year all-cause deaths; the HRs and 95th confidence intervals were 1.02 (1.00, 1.05), 1.02 (1.00, 1.04), 1.02 (1.00, 1.03), and 1.02 (1.00, 1.03), respectively.

Conclusion

Serum sodium levels were u-shaped about all-cause mortality. In individuals with CHF, serum sodium levels are linked to an elevated risk of short-, medium-, and long-term all-cause mortality.
Research review and prospects of the 2000 giant Yigong long-runout landslide: Volume, formation mechanism and recurrence period, Tibetan plateau, China
Authors: Guo Changbao , Yuan Hao , Wu Ruian , Yan Yiqiu , Yang Zhihua
Published: January 2023

The long-runout landslide is an unusual landslide with great drop height, long sliding distance, large volume, and high velocity, which is characterized by strong kinetic energy, fragmentation and entrainment effect. The landslide and its induced hazard chain may produce serious consequences. Based on remote sensing interpretation, field investigation and simulation, this paper summarizes the research progress of the 2000 giant Yigong long-runout landslide in Tibet, analyzes the initiating mechanism, volume and sliding velocity of the Yigong landslide, and further reveals that endogenic and exogenic geological processes are the main influencing factor of the Yigong landslide. It is also found that the landslide has a periodic initiating mechanism with characteristics of head-cut and recurrence. However, there are great differences in the existing studies on the volume of the slide source zone in the Yigong landslide. This paper calculates the landslide volume based on ArcGIS spatial analysis and obtains an initial landslide volume of approximately 9.225 × 107 m3. The landslide final deposition volume is approximately 2.81∼3.06 × 108 m3, which is consistent with the other researchers. Moreover, there are two potential dangerous rock mass in the slide source zone, with a total volume of approximately 1.86 × 108 m3. Dangerous rock mass may form the hazard chain of landslide-river blockage-dam break again and lead to significant disasters. Hence, we suggest the following research on Yigong landslide: Stability of the potential dangerous rock mass in the slide source zone, the prediction of the hazard chain, monitoring and early warning for the landslide. It is of great significance to guide the construction of major projects such as railway and hydropower projects and hazard prevention and mitigation in this area.
Time-dependent deformation of Wufeng-Longmaxi shale and its implications on the in situ state of stress
Authors: Cheng Wei , Zhang Xiaowen , Jin Juan , Liu Jiandong , Jiang Weidong , Zhang Guangming , Zhang Shihuai , Ma Xiaodong
Published: January 2023

The stress-strain relationship in shales is generally time-dependent. This concerns their long-term deformation in unconventional reservoirs, and its influence on the in situ stress state therein. This paper presents an experimental investigation on the time-dependent deformation of the Longmaxi shale gas shale. A series of creep experiments subject the shale samples to long-term, multi-step triaxial compression. It is found that the shale samples exhibit varying degrees of time-dependent deformation, which can be adequately described by a power-law function of time. The experimental results establish the relationship between the elastic Young’s modulus and viscoplastic constitutive parameters, which are different from previous those derived from North American shales. Based on this viscoplastic constitutive model, the stress relaxation and the differential stress accumulation over geologic time scales can be estimated. It is found that linear elasticity substantially overestimates the differential stress accumulation predicted in the context of viscoplastic relaxation. The characterized viscoplasticity and stress relaxation are of vital importance for various geomechanical problems in shale reservoirs.
Polyphase deformation of the Youjiang fold-and-thrust belt during the Mesozoic: Implications for the tectonic transition of the South China block
Authors: Hu Jia-Xiu , Xiao Chang-Hao , Wei Chang-Shan , Shen Yu-Ke , Chen Zheng-Le , Zhang Yu , Zhang Da
Published: January 2023

The South China block (SCB) experienced the tectonic transition from the Paleo-Tethys to the Paleo-Pacific tectonic domains during the Mesozoic, but the transition process is hotly debated. The Youjiang fold-and-thrust belt (YFTB), in the interior of the Youjiang Basin in the southwestern SCB, is located in a junction of these two tectonic domains and thus witnessed their tectonic evolution. It also separates the northern thin-skinned structures from the southern thick-skinned structures in the basin. Therefore, the YFTB is an intriguing window into the Mesozoic evolution in the southwestern SCB and the Mesozoic tectonic transition of the SCB. In this study, we conduct structural analysis at the middle of the YFTB and discuss the Mesozoic tectonic transition of the SCB. Four phases of deformation are identified in the YFTB during the Mesozoic. The first phase of deformation (D1) is characterized by a series of conjugate joints, NW–SE trending thrust faults and folds resulting from NE–SW shortening that was related to the collision between the SCB and Indochina block. The second phase of deformation (D2) is manifested by the pre-existing NW–SE striking thrust faults transformed to normal faults and the Late Triassic mafic magmatism. Our structural observations, combined with previous geochronological data for mafic dykes, suggest the study area experienced post-orogenic extension in the Late Triassic. The third phase of deformation (D3), accompanied with the westward subduction of the Paleo-Pacific oceanic plate, is represented by a series of conjugate joints and NE–SW-striking faults formed by NW–SE compression. As a result of the continuous subduction of the Paleo-Pacific plate and its subsequent slab rollback, the fourth phase of deformation (D4) is featured with normal faults, magmatic-hydrothermal activities, and regional mineralization, which are associated with the nearly E–W extension setting. Our study results indicate that, in the Early Mesozoic, the Youjiang Basin was dominated by the Paleo-Tethys domain and then transitioned to the Paleo-Pacific domain. Together with the magmatic lull between the Triassic and the Early-Middle Jurassic identified in the SCB, we propose that the tectonic transition process manifested in the YFTB more likely initiated in the Early Jurassic.
Landslide mechanism and stability of an open-pit slope: The Manglai open-pit coal mine
Authors: Chen Tao , Shu Jisen , Han Liu , Tovele Gerson. S. V. , Li Baosheng
Published: January 2023

A clear understanding of landslide mechanisms and stability analyses is of great significance for landslide monitoring, prediction, and control. A large-scale end wall landslide occurred and its area reached 47,752 m2 on August 7–20, 2020, in the Manglai open-pit coal mine, China. In this paper, the engineering geological survey, mechanical test, large-deformation finite element numerical method, limit equilibrium method and analytical formula are used to analyze how the groundwater level rise caused this end wall failure and landslide. The engineering geological conditions, hydrogeological conditions, landslide activity signs and physical and mechanical parameter calibration of the sliding mass are investigated in detail and tested. Three-dimensional and two-dimensional numerical models of slopes are established, and an analytical formula calculation method to calculate the factor of safety (FoS) is proposed when sliding cracks are located on the top and toe of a slope. The results indicate that the fault fracture zone, soft strata, continuous heavy rainfall, and groundwater were the main contributors to this landslide. The three-dimensional numerical calculation results are consistent with the deformation and failure process of the slope observed in the field, which shows a retrogressive progressive failure mode. The calculation results of SLOPE/W and the analytical formula are consistent; i.e., when the groundwater level rises to +950, the stability of the end wall reaches the critical stability state. With the passage of time, the creep of the sliding surface accelerates until the entire end wall landslide.
Application of GMDH model to predict pore pressure
Authors: Gao Guozhong , Hazbeh Omid , Rajabi Meysam , Tabasi Somayeh , Ghorbani Hamzeh , Seyedkamali Reza , Shayanmanesh Milad , Radwan Ahmed E. , Mosavi Amir H.
Published: January 2023

Pore pressure (PP) is one of the essential and very critical parameters in the oil and gas industry, especially in reservoir engineering, exploitation, and production. Forecasting this valuable parameter can prevent huge costs incurred by the oil and gas industry. This research aims to develop a algorithm to better predict PP in subsurface -formations. Based on this, information from three wells (F1, F2, and F3) representing one of the Middle East oil fields was used in this research. The input variables used in this research include; laterolog (LLS), photoelectric index (PEF), compressional wave velocity (Vp), porosity (NPHI), gamma ray (spectral) (SGR), density (RHOB), gamma ray (corrected) (CGR), shear wave velocity (Vs), caliper (CALI), resistivity (ILD), and sonic transit time (DT). Based on the results presented in the heat map (Spearman’s correlation), it can be concluded that the pairs of parameters RHOB-PEF, CGR-SGR, RHOB-CALL, DT-PEF, PP-RHOB, Vs-RHOB, ILD-LLS, DT-CGR, and DT-NPHI are connected. In this research the GS-GMDH methods is used for modeling which is based on the Group method of data handling (GMDH). The results of this research show that this algorithm has an average error of RMSE = 1.88 Psi and R2 = 0.9997, indicating its high-performance accuracy. The difference between this method and the conventional GMDH method is that it can use three or more variables instead of two, which can improve prediction accuracy. Furthermore, by using the input of each neuron layer, the proposed model can communicate with other adjacent and non-adjacent layers to solve complex problems in the simplest possible way.
Wave current force test of deep water foundation of bridge in marine environment
Authors: Li Ling , Yue Ling , Xing Xiao-Fu
Published: January 2023

As a key parameter in the design and construction of the Sea Crossing Bridge, the wave and current load on the pile foundation has been the subject of extensive research. The magnitude and distribution of wave and current loads on pile foundations are crucial for the safety of the foundation. Based on Male Airport Island Bridge Project in the Maldives, the wave current force of platform pile and steel casing in different construction stages is investigated, and the horizontal force and bending moment of the foundation under various wave and current parameters are tested using an indoor model. The results are as follows: 1) With the same effective wave height and wave period, the maximum horizontal force and bending moment on the pile exhibit a linear relationship to the wave velocity. Under the same water depth, the combined wave current force is greater than the sum of wave force and simple current force, with a maximum difference of 70%; 2) Under 2-year return period wave and current conditions, the horizontal stress on a single platform pile and steel casing increases linearly with the increase in height, and there will be nonlinear relationship with 10-year return period wave and current conditions; 3) With more platform piles and steel casing, the front row piles have obvious protective effect on the rear row piles, and the horizontal force and bending moment of the overall structure increase nonlinearly.
The drag effects of energy-water constraints on China’s economic growth under carbon mitigation goals
Authors: Yu Xinxin , Chen Yifan , Jiang Mingdong , Zhong Guanyu , Xu Heyichen , Shen Xiaomei , Kong Qianhui
Published: January 2023

Energy and water resources function as the base for humans’ socioeconomic development, which are closely linked with each other in the production process. With the rapid economic development, the contradiction between the supply and demand of energy and water resources has become acute. Meanwhile, the carbon reduction goals further enhanced the energy and water constraints, which inevitably have a significant impact on economic growth. Exploring the effect of energy and water constraints on the economic growth under climate goals is essential for policy maker to minimize the economic loss during carbon control. To realize this aim, we introduced the modified Romers’ economic growth model to estimate the impact of energy-water constraints on economic growth based on relative data in 30 provinces in China from 2000 to 2019. Then the spatial-temporal characteristics of the energy-water drag effects on China’s economic growth have been analyzed. We further applied scenario analysis method to investigate the changes in growth drag effects of energy and water resources under carbon mitigation goals in 2025 and 2030. The results show that China’s economic growth rate was reduced by 7.72% and 7.99% during the study period due to energy and water resources constraints respectively. In terms of the temporal trend, the energy-water growth drag effect shows a downward trend as a whole during 2000–2019, and the growth drag of energy on economic growth is slightly greater than that of water resources. As to spatial distribution, regions with high constraint effects of energy and water on economic growth are mainly located in the East China, while some north regions feature low energy-water constraints. According to the simulation results, China’s energy-water drag effects on the economic growth are 6.85% and 7.03% respectively, under the baseline and strong carbon control scenarios, higher than the 6.53% under the weak carbon control. Based on this, this paper proposes to design targeted energy-water constraint strategies and promote production efficiency to achieve a win-win situation of economic development and dual-carbon goals.