bluuebunny/crossref_metadata_2025 huggingface dataset:
Phytochemical investigation of Helianthemum lippii l. aerial Dum.Cours part and evaluation for its antioxidant activities
Authors: LAİB Ibtissam , DJAHRA Ali Boutlelis
Published: May 2022

Objective: The aim of this study is to determine the phytochemical contents and the antioxidant activity of Helianthemum lippii (L.) Dum.Cours. crude extract.
Methods: For preliminary phytochemical analysis, standard procedures were applied, while identification and quantification of individual phenolic compounds were performed by HPLC analysis. The Folin–Ciocalteu method was used to evaluate the total phenolic acid content of the plant extracts, The total flavonoid content was determined using the aluminum chloride colorimetric assay. The FTIR spectroscopy method was used to examine the chemical makeup of the organic extracts. The antioxidant activities were assessed using the 1,1-diphenyl-2-picrylhydrazyl and reducing power assays.
Results: Chemical analysis revealed the presence of numerous secondary metabolites, such as polyphenols, flavonoids, tannins, saponins, anthocyanins, cardiac glycosides, leuco anthocyanins steroids, terpenoids, alkaloids, and mucilage. For the HPLC analysis, we obtained 65 peaks and we identified 6 major elements of bioactive compounds. The total concentration of polyphenols and ﬂavonoids was varied respectively 183.12±2.84 mg gallic acid eq/g dry wt and 72.00±1.03 mg quercetin eq/g dry wt /mg. The general concentration of condensed tannin and hydrolyzable tannin compounds were expressed in terms of catechin equivalent (5.88±1.58 mg Ca eq/g dry extract) and gallic acid (2.818±0.138 mgTA eq/g dry wt) respectively. FTIR spectroscopy investigation indicated several characteristic peak values in the extract with diverse functional groups such as amide, alcohol, and phenol groups. Concerning the antioxidant activity, we found that this extract has high inhibitory percentages equivalent to IC50 3.085±0.001 for DPPH and 1.724±0.021 for reduction power (µg/mL).
Conclusion: Our study proved that the aqueous extract of the H lippii is very rich in secondary metabolites; in addition, it has a tremendous anti-oxidant capacity, which leads us forward to introduce it for medical use.
Accuracy of restricted Boltzmann machines for the one-dimensional $J_1-J_2$ Heisenberg model
Authors: Viteritti Luciano Loris , Ferrari Francesco , Becca Federico
Published: May 2022

Neural networks have been recently proposed as variational wave functions for quantum many-body systems [G. Carleo and M. Troyer, Science
355, 602 (2017)]. In this work, we focus on a specific architecture, known as restricted Boltzmann machine (RBM), and analyse its accuracy
for the spin-1/2 J_1-J_2J1−J2
antiferromagnetic Heisenberg model in one spatial dimension. The ground
state of this model has a non-trivial sign structure, especially for
J_2/J_1>0.5J2/J1>0.5,
forcing us to work with complex-valued RBMs. Two variational Ansätze are
discussed: one defined
through a fully complex RBM, and one in which two different real-valued networks are used to approximate modulus and phase of the wave function.
In both cases, translational invariance is imposed by considering linear combinations of RBMs, giving access also to the lowest-energy excitations
at fixed momentum k. We perform a systematic study on small clusters to evaluate the accuracy of these wave functions in comparison to exact
results, providing evidence for the supremacy of the fully complex RBM. Our calculations show that this kind of Ansätze is very flexible
and describes both gapless and gapped ground states, also capturing the incommensurate spin-spin correlations and low-energy spectrum for
J_2/J_1>0.5J2/J1>0.5. The RBM results are also compared to the ones obtained with Gutzwiller-projected fermionic states, often employed to describe
quantum spin models [F. Ferrari, A. Parola, S. Sorella and F. Becca, Phys. Rev. B 97, 235103 (2018)]. Contrary to the latter class of
variational states, the fully-connected structure of RBMs hampers the transferability of the wave function from small to large clusters, implying
an increase in the computational cost with the system size.
Isolated Coarctation Repair in Neonates and Infants Through Left Thoracotomy: Short-Term Outcomes
Authors: Murakami Alexandre Noboru , Croti Ulisses Alexandre , Cajueiro Francisco Candido Monteiro , Arteaga Grace , Pike Roxann Barnes , Moscardini Airton Camacho , Marchi Carlos Henrique De , Cardoso Mariana Ribeiro Rodero , Santos Fernando Cesar Gimenes Barbosa , Borim Bruna Cury
Published: May 2022

Introduction: End-to-end anastomosis and extended end-to-end anastomosis are typically used as surgical approaches to coarctation of the aorta (CoAo) with access at the subclavian artery or an interposition graft. The objective of this study is to analyze the impact of surgical and anatomical characteristics and techniques on early outcomes after surgical treatment of CoAo without cardiopulmonary bypass through left thoracotomy. Methods: This is a quantitative, observational, and cross-sectional analysis of patients who underwent repair of CoAo between July 1, 2010 and December 31, 2017. Seventy-two patients were divided into three groups according to age: 34 in group A (≤ 30 days), 24 in group B (31 days to one year), and 14 in group C (≥ 1 year to 18 years). Results: Aortic arch hypoplasia was associated in 30.8% of the cases, followed by ventricular septal defect (13.2%). The preductal location was more frequent in group A (73.5%), ductal in group B (41.7%), and postductal in group C (71.4%). Long coarcted segment was predominant in groups A and C (61.8% and 71.4%, respectively) and localized in group B (58.3%). Extended end-to-end anastomosis technique was prevalent (68%), mainly in group A (91.2%). Mortality in 30 days was 1.4%. Conclusion: Most of the patients were children under one year of age, and extended end-to-end anastomosis was the most used technique, secondary to arch hypoplasia. Further, overall mortality was low in spite of moderate morbidity in the first 30 postoperative days.
Atomization of living space and diffusion of labor activity in the context of coronacrisis: manifestations, consequences and vectors of overcoming
Authors: Kolot Anatoliy , Herasymenko Oksana , Marshavin Yurii
Published: May 2022

The symbiosis of new opportunities caused by the breakthrough technologies of the digital age (“big bang-1”) and new challenges and threats caused by sanitary and epidemiological requirements of the coronavirus pandemic (“big bang-2”) leads to a reduction in the living space of an economically active person. The ability to work remotely using information and communication systems (voluntary isolation), on the one hand, and quarantine restrictions (forced isolation), on the other, lead to atomization of a person. At the same time, the time boundaries between work and leisure are being erased, leisure acquires signs of precariousness, a convergence of work and leisure takes place. The relevance of this study is due to the need for a renewed awareness of what kind of format of labor activity will be there in the pandemic and post-pandemic era. Scientific and practical significance of the study is to determine restoration vectors of humancentered, socially acceptable living space of a man of labor, which will help overcome coronacrisis in the social and labor sphere. The main result of the study is the author’s mental model of metamorphoses of labor activity as a component of the new (ab)normality of pandemic and post-pandemic eras. The research subject is the theoretical and applied principles of atomization of the living space of economically active people and the diffusion of labor under the influence of new opportunities and constraints produced by the digital economy and the challenges of the COVID-19 pandemic. The methodological basis for achieving the set goal is a systematic approach that allows avoiding the fragmentary nature of research, one-sided judgments and conclusions in the study of the interrelated phenomena of living space atomization and labor activity diffusion. The aim of the study is to form scientific ideas about transformations taking place in the field of labor and leisure in the digital age under the influence of coronacrisis. It is proved that the coronacrisis gives rise to a new type of person – an atomized one, which is being increasingly exposed to «negative» individualism influence. The study outlines the contours of the mental model of the organization of work activity in the post-COVID period based on overcoming «negative» individualism, the emergence of a new philosophy of the time, and the formation of an updated concept of leisure culture. Also, the necessity of developing a consolidated multilevel model of social and labor relations in the new socio-economic reality and scientific and applied scenario of its implementation in the system of social and labor development of Ukrainian society is substantiated.
Oxidative Stress in Type 2 Diabetes and The Impact of Exercise: from mitochondria to glucose management in skeletal muscle
Authors: Santos Julia Matzembacher dos , Heck Thiago Gomes
Published: May 2022

Oxidative stress is the result of reactive oxygen species (ROS) overproduction and/or a decline in antioxidant defense mechanisms. Oxidative stress can be marked by deleterious effects on DNA, proteins, and lipids structure, changing cell homeostasis, and contributing to the development of metabolic diseases as type two diabetes (T2D), characterized mainly by insulin resistance in several tissues, as skeletal muscle.  The T2D development and its complications are related to mitochondrial dysfunction and oxidative stress, as well as pro-inflammatory state and metabolic unbalance. Acute exercise represents a necessary type of challenge to whole-body homeostasis. Therefore, regular exercise (sum of acute exercise challenges) promotes antioxidant, anti-inflammatory, and metabolic adaptations induced by each stress induced by the exercise session, evoking a hormesis effect (from mitochondria to many tissues) that is beneficial for T2D prevention and treatment. Despite of a considerable research information in the field, the characterization of the sources and pathways of ROS generation in T2D and during exercise still a matter for investigation. Therefore, the multifaceted effects of oxidative stress in T2D and the link of exercise in T2D are discussed in this review.
Cognitive-Discursive Modeling of Language Nomination
Authors: Tagaev M. Dzh.
Published: May 2022

Systemic and structural linguistics has no answer to the question of how one can make new words, as formulated by Prof. L. V. Shcherba. Its methodology strives to distance itself from the human factor and human activity. The present article introduces an analysis of two derivatological concepts. The first one was developed by G. S. Zenkov, a prominent representative of the structural direction in Kyrgyz linguistics. The second belonged to L. A. Araeva, the founder of the Kemerovo derivatological school with its anthropocentric orientation. The processes of knowledge processing are consolidated by means of morphemic, semantic, and syntactic derivation. The national and cultural component of lexical meaning of motivated words, created by morphemic and semantic derivation, develops in a particular cognitive and discursive situation. This situation becomes clear if approached from the standpoint of another language. A language appears, develops, and functions not by the standards of an abstract person, but by those of a particular language user as part of a particular national, cultural, natural, and economic environment that gave rise to a particular ethnos. Consequently, the processes of creating new words cannot be studied abstractly and formally, but only as a response to the requests and challenges of a particular ethnic community.
Linguistic Representations of Disgust in the Modern German Language
Authors: Korogodina I. V.
Published: May 2022

The present research featured linguistic units of the primary and secondary nomination, as well as expressive interjections, which describe the emotion of disgust and its physiological characteristics. The purpose of the research was to analyze the linguistic representations of disgust and to describe the physiological characteristics that reflect the fundamental status of the emotion. The study focused on the German lexeme Ekel, linguistic metaphors, metaphors with somatic components, and expressive interjections. The authors analyzed linguistic representations of the emotion of disgust, outlined its somatic components, described its physiological characteristics, defined the actual linguistic nomination of disgust, classified linguistic metaphors and metaphors with the somatic components according to linguistic hierarchy, and analyzed the somatic components that reflect the physiological characteristics of disgust. The emotion of disgust appeared to be based on such physical sensations as choking, nausea, and vomiting. The expressive interjections proved to reflect the intensity of the emotion. Disgust is represented at three levels: non-verbal – by facial expressions and gestures; physiological – nausea, asthma attacks, gag reflex; verbally – the base lexeme-representative der Ekel, the metaphor-word die Grenze, the metaphorword with the somatic component Brechmittel, the metaphor-phrase Ekel schüren, the metaphor-sentence with the somatic component Das Ekelhafte würgt mich, and the expressive interjections Bäh!, Ih!, Igitt!, Pfui!
Sustainable water resource planning at the basin scale with simultaneous goals of agricultural development and wetland conservation
Authors: Hatamkhani Amir , KhazaiePoul Ahmad , Moridi Ali
Published: May 2022

Reducing the quantity of water in recent years has increased the competition between development projects and the environment. Wetlands are increasingly under pressure due to human activities. The most serious threats to wetlands are excessive agriculture and the diversion of water for irrigation. In recent years, due to water shortage and drought, wetland dryness in Iran has caused many problems, including the dust crisis. Therefore, planning at the basin scale is necessary to achieve sustainable development, which emphasizes the employment of mathematical models. In this study, using a reliability-based simulation–optimization approach, development planning in the Karkheh basin with the following two objectives is investigated: (1) total area under cultivation of agricultural development sectors and (2) supply reliability of the environmental flow requirement. The Water Evaluation and Planning (WEAP) model is used for the simulation of water resources and the multi-objective particle swarm optimization (MOPSO) algorithm is employed for optimization. The results show that in addition to significantly improving the supply reliability of the wetland requirement (from 55 to 79%), the design of agricultural development projects has been optimized. The reliability-based model has prevented unsustainable developments in the basin. Also, the average supply reliability of agricultural demands has increased from 51% (in previous studies) to 72%.
Mixing of Fe3O4 nanoparticles under electromagnetic and shear conditions for wastewater treatment applications
Authors: Liosis C. , Karvelas E. , Karakasidis T. , Sarris I.
Published: May 2022

The ability of heavy metals to accumulate in living organisms, combined with the fact that they are not biodegradable, necessitates an expansion and improvement of the existing water purification methods. An effective mixing of contaminated water with heavy metals and magnetic nanoparticles is crucial for water treatment applications. In the present work, electromagnetic and shear mixing are combined to explore optimization mixing strategies. Mixing is studied through simulations under various initial conditions for two streams that are loaded with nanoparticles and one contaminated water stream that lies between the nanoparticle streams. In the present work, magnetic mixing is superimposed with a time-modulated gradient external magnetic field. The results show that as the radius ratio between the nanoparticles and the heavy metals increases, the external magnetic field is more effective insofar as the mixing of the nanoparticles is concerned. Moreover, for simulations where the radius ratio is higher than or equal to 10, an effective mixing is achieved. By comparing the velocity ratios, a better mixing is achieved in the case of higher velocity ratios. Also, minor effects on mixing are observed by comparing the ratios Vp/Vc = 10 and Vp/Vc = 20.
Irrigation water demand management with emphasis on pricing policy
Authors: Mohseni Simin , Zare Mehrjerdi Mohammad Reza , Abdolahi Ezzatabadi Mohammad , Mehrabi Boshrabadi Hossein
Published: May 2022

Serious constraints in increasing water supply have led countries around the world to seek solutions for managing water demand. Proper pricing of water is one of the foremost water demand management policies which can lead to the optimal water use. On the flip side, the quality of agricultural water is declining due to the uncontrolled abstraction of groundwater. In this regard, the present study aims to determine the economic value of different qualities of water throughout pistachio-growing regions of the Rafsanjan-Anar plain in Iran. Results reveal that the economic value and price elasticity of water demand differ among different groups. Freshwater, moderately saline water and highly saline water have the highest to lowest elasticity and shadow price, respectively. Additionally, comparison of the gross margin, which represents the profit from each activity, in two conditions including the unsustainable status quo and sustainable conditions intended by the Ministry of Energy, shows that although water use has declined by 50%, the gross margin has decreased by only 36%. This implies it is feasible to reduce water use in pistachio orchards by water re-allocation with a minimum decline in profit, which will both reduce water use and ensure high economic benefits for farmers.
Estratégia, método e conteúdo: três componentes para compreensão das campanhas contemporâneas de desinformação
Authors: Silva Max , Valadares Cendón Beatriz
Published: May 2022

A profusão de desinformação na web atualmente ocorre com emprego de crescente refinamento e emprego de recursos tecnológicos, linguísticos e métodos capazes de amplificar seu alcance. O presente trabalho buscou compreender, a partir de revisão de literatura, estratégias, métodos e forma de organização do conteúdo nas campanhas de desinformação contemporâneas para propor um modelo para compreensão e análise dessas campanhas. Foram realizadas pesquisas em diversas bases de dados que resultaram na identificação de 18 trabalhos que discutem a dinâmica da desinformação – elementos constitutivos anteriores à manifestação do fenômeno. O conteúdo dessa revisão foi organizado em uma tipologia própria que permitiu conceber três componentes básicos das campanhas de desinformação contemporâneas: estratégia, método e conteúdo. O trabalho descreve e discute esses componentes, cuja compreensão contribui para a análise da desinformação e o desenvolvimento de ferramentas dissuasivas, mitigatórias ou corretivas. O trabalho evidenciou que as campanhas ocorrem com elevado grau de profissionalismo, planejamento e financiamento, de tal forma que soluções simplórias de enfrentamento da desinformação tendem a ser pouco eficazes. Ações de letramento e desenvolvimento de competências informacionais precisam ser acompanhadas de outras iniciativas por parte de governos e empresas de tecnologia da informação.
Historia i prezentacja Wydziału Studiów nad Rodziną UKSW w Warszawie (2010-2020)
Authors: Ozorowski Mieczysław
Published: May 2022

Celem artykułu jest przedstawienie historii i działalności Wydziału Studiów nad Rodziną UKSW w Warszawie w latach 2010-2020, a więc okres dziesięciu lat istnienia tego Wydziału jako odrębnej instytucji w ramach uniwersytetu. Najpierw omówiono historię Instytutu Studiów nad Rodziną, powołanego w ramach Akademii Teologii Katolickiej w Warszawie, będącego źródłem pochodzenia przyszłego Wydziału. W dalszej części tekstu zaprezentowano kolejne losy bazy lokalowej, przedstawiono założenia i cele dydaktyki w Wydziale, omówiono formy opieki nad studentami oraz kadrę Wydziału i sposoby zarządzania oraz różne formy współpracy z otoczeniem gospodarczym i ośrodkami naukowymi w Polsce i za granicą.
Jan Polák, Toccamenti proibiti. Aspetti antropologici ed etici della masturbazione, Edizioni Sant’Antonio, Beau Bassin 2018, ss. 131.
Authors: Kućko Wojciech
Published: May 2022

Rewolucja seksualna objawiła i znacząco rozszerzyła różne problemy związane z przekazywaniem życia, a także z ludzką seksualnością. Dla wielu, nie tylko wierzących, trudne są do przyjęcia dotychczasowe, sprawdzone argumenty ukierunkowane na poszanowanie sfery seksualnej i promowanie jej właściwego rozwoju. Tym bardziej aktualne i pożądane wydaje się poszukiwanie nowych form opisu i oceny moralnej zjawisk i zachowań dotyczących ludzkiej seksualności. Bardzo trudnym tematem w tej dziedzinie jest zagadnienie oceny etycznej masturbacji, przez jednych traktowane jako zwykły sposób zaspokojenia popędu seksualnego, przez innych zaś rzeczywistość demonizowana i naznaczona różnymi wypaczeniami. Ogromny wpływ na ocenę moralną mają w tej dziedzinie współczesne środki społecznego przekazu, a zwłaszcza Internet.

W tym kontekście bardzo ważna wydaje się praca czeskiego kapłana, ks. Jana Poláka, będąca owocem jego badań naukowych podczas studiów w Accademia Alfonsiana – Wyższym Instytucie Teologii Moralnej w Papieskim Uniwersytecie Laterańskim w Rzymie, która powstała z pomocą wybitnego włoskiego bioetyka i teologa moralisty o. prof. Maurizio Faggioniego OFM.

Opublikowana we włoskim wydawnictwie Edizioni Sant’Antonio, licząca 131 stron książka w języku włoskim, zawiera cztery rozdziały, w których w sposób logiczny i konsekwentny zaprezentowano badaną materię.
Evolving Era of “Sponges”: Nanosponges as a Versatile Nanocarrier for the Effective Skin Delivery of Drugs
Authors: Mullick Prashansha , R. Hegde Aswathi , Gopalan Divya , Pandey Abhijeet , Nandakumar Krishnadas , Jain Sanyog , Kuppusamy Gowthamarajan , Mutalik Srinivas
Published: May 2022

Background:

Nanosponge, as a carrier for the skin delivery system for drugs, plays a vital role. It not only serves to administer the drug to the targeted layer of skin but also increases the drug retention and deposition on the skin.

Objective:

In this review, we aim to highlight the effects of several processes and formulation variables prompting the characteristics of various nanosponges for the delivery of drugs into/ across the skin.

Method:

In the present review article, the overall introduction of nanosponges, their preparation, characteristic features, advantages, disadvantages, and factors affecting their preparation, are covered. Furthermore, an elaborative description of nanosponges for skin delivery and its toxicological perspective with some referential examples of nanosponge drugs has also been deliberated here.

Results:

Factors associated with the formation of nanosponges can directly or indirectly affect its efficacy in the skin delivery of drugs. These nanoforms are efficient in delivering the drugs which possess lower aqueous solubility, therefore, the aqueous solubility of drugs possessing a narrow therapeutic window can easily be enhanced. It also helps in achieving targeted drug delivery, controlled release of drugs, increases bioavailability, reduces drug toxicity, decreases drug degradation, and many more.

Conclusion:

Nanosponges have been identified as potential drug delivery carriers into as well as across skin. Delivery of biologics such as vaccines, enzymes, peptides, proteins, and antibodies, is also gaining attention in the recent past.
The Anti-atherosclerotic Effects of Natural Polysaccharides: From Phenomena to
the Main Mechanisms of Action
Authors: P. Karagodin Vasily , I. Summerhill Volha , Yet Shaw-Fang , Orekhov Alexander N.
Published: May 2022

Polysaccharides (PSs) of plant origin have a variety of biological activities, including antiatherosclerotic,
but their use in atherosclerosis therapy is hindered by insufficient knowledge based on the cellular
and molecular mechanisms of action. In this review, the influence of several natural PSs on the function of
macrophages, viral activity and macrophage cholesterol metabolism has been discussed, considering the tight
interplay between these aspects in the pathogenesis of atherosclerosis. The anti-atherosclerotic activities of natural
PSs related to other mechanisms have also been explored. Directions for further research of the antiatherosclerotic
effects of natural PSs have been outlined, the most promising of which can be nutrigenomic
studies.
A Review on the Catalytic Applications of Polyaniline Supported Palladium (Pd@PANI) in C–C Coupling Reactions
Authors: Naidu Bandameeda Ramesh , Maddeboina Krishnaiah
Published: May 2022

The C ̶ C bond formation via the cross-coupling and homocoupling reactions of organic partners are central to the synthesis of many chemical probes and have valuable applications in the medicinal and pharmaceutical industries. Polyaniline (PANI) is the most useful performing polymer due to its non-toxicity, high stability, easy synthetic accessibility, and simplicity of doping/dedoping by treatment with aqueous acid and base. PANI plays a pivotal role as a polymer base for palladium (Pd) species and in most cases, the catalysts showed high yield, reaction transformation, and reusability. In this review, we discuss the application of the Pd@PANI catalyst for cross-coupling/homocoupling reactions, analysis, characterization, and reusability. We covered all literature about Pd@PANI catalyst functions in Suzuki-Miyaura, Heck, Sonogashira, and Ullmann coupling reactions.
Mathematical Oncology to Cancer Systems Medicine: Translation from
Academic Pursuit to Individualized Therapy with MORA
Authors: Majumder Durjoy
Published: May 2022

Aim & Objective:

This article is aimed to understand the gradual development of cancer systems medicine and how this provides a better therapeutic strategy (in terms of drug selection, dose and duration) and patients care. Hence, this study is focused to understand the need and the evolving nature of the analytical models for the assessment of the outcome of different cancer therapeutics.

Background:

Presently, cancer is viewed from a quantitative standpoint; hence, several analytical models on different cancers have developed. From the information of cancer development to therapeutic advantage, mathematical oncology has contributed significantly. With a fewer number of variables, models in this area have successfully synchronized the model output with real-life dynamical data. However, with the availability of large scale data for different cancers, systems biology has gained importance. It provides biomedical insights among a large number of variables. And to get information for clinically relevant variables especially, the controlling variable(s), cancer systems medicine is suggested.

Methods:

In this article, we have reviewed the gradual development of the field from mathematical oncology to cancer systems biology to cancer systems medicine. An intensive search with PubMed, IEEE Xplorer and Google for cancer model, analytical model and cancer systems biology was made and the latest developments have been noted.

Results:

Gradual development of cancer systems biology entails the importance of the development of models towards a unified model of cancer treatment. For this, the model should be flexible so that different types of cancer and/or its therapy can be included within the same model. With the existing knowledge, relevant variables are included in the same model, followed by simulation studies that will enrich the knowledge base further. Such a deductive approach in the modelling and simulations efforts can help to tackle the adversity of individual cancer cases in future. This approach is indeed important to encompass the fourth industrial revolution in health sector.

Conclusion:

Towards the development of a unified modelling effort, a multi-scale modelling approach could be suitable; so that different researchers across the globe can add their contribution to enrich the same model. Moreover, with this, the identification of controlling variables may be possible. Towards this goal, middle-out rationalist approach (MORA) is working on analytical models for cancer treatment.
Nutraceutical Potential and Processing Aspects of Moringa oleifera as a
Superfood
Authors: Kaur Simranjeet , Chauhan Pratik N. , Harwansh Ranjit K. , Chakma Marjita , Kaur Simran
Published: May 2022

Plants are used by almost 80% of the world's population for health and healing, and medicinal and aromatic plants account for 25% of all integrated pharmaceuticals. Moringa oleifera is a multi-purpose herbal plant that is utilized as a portion of human food and a therapeutic alternative all over the world. According to studies, it has been discovered as a plant with a wide range of health benefits, including nutritional and medicinal characteristics. It can live on nutrient-depleted soils and is drought-resistant, and it flourishes in wet tropics and scorching dry regions. With a pH of 5.0–9.0 and a minimum annual rainfall need of 250 mm and a maximum annual rainfall demand of over 3000 mm, it can endure a wide variety of rainfall. Moringa is a plant that can aid in the fight against climate change. Moringa’s ability to respond to water stress and its tolerance to it were investigated in this study. Moringa is used in traditional medicine all over the world for a variety of ailments, including skin infections, anemia, anxiety, asthma, blood impurities, bronchitis, chest congestion, cholera, infections, fever, glandular, swelling, headaches, abnormal blood pressure, hysteria, pain in joints, pimples, psoriasis, respiratory disorders, scurvy, semen deficiency, sore throat, sprain, tuberculosis, for intestinal worms, lactation, diabetes, and pregnancy. Moringa oil is prized in the cosmetic business because of its unique properties. Moringa oil is light and easily absorbed by the skin. It's ideal for massage and aromatherapy purposes. Although M. oleifera's nutritional value is lower than that claimed by popular nutritional claims, its abundance in food-insecure areas and wide range of nutrients keep it viable as a nutritious food source for populations in low- and middle-income countries. Malnutrition, which includes undernutrition, micronutrient deficiency, and overnutrition, is more widespread than hunger per se and affects most nations around the world. The diversity and quality of food produced and consumed are crucial in reducing the triple burden of malnutrition. In this climate, fruit, vegetables, and nuts are quickly becoming the focus of the nutrition community. Moringa's diet is higher in polyunsaturated fatty acids (PUFAs) than in saturated fatty acids (SFAs).
The Effect of Substituents and Functional Groups on Enhancing the Antioxidant Activity of Benzoin Derivatives
Authors: Balasundaram Thanuja , Kripa Kavasseri Ganesan , Bhavadharani Thiyagarajan , Kanagam Charles
Published: May 2022

Background:

2-phenyl hydrazine-1-hydroxy, 1-[2-chlorophenyl] -2-4’-methoxyphenyl] ethane and 2-oxime-1-hydroxy, 1-[2-chlorophenyl] -2-4’-methoxyphenyl] ethane derivatives of benzoin have been synthesized from 2’chloro-4-methoxy benzoin by addition reaction. Structural elucidation of the synthesized compounds was carried out through FT-IR, FT-NMR studies. The presence of electron-withdrawing and electron-donating groups enhanced the antioxidant activity, which was analyzed by 2,2-diphenyl-1-picrylhydrazyl assay, 2,2'-azino-bis (3-ethylbenzothiazoline-6- sulfonic acid) scavenging assay, hydrogen peroxide radical scavenging assay, and Ferric reducing antioxidant power assay methods. The effect of functional groups and substituents in the core structure was studied and compared with its parent compound.

Aim and Objective:

In this manuscript, two derivatives of benzoin viz. 2-phenyl hydrazine-1-hydroxy, 1-[2-chlorophenyl] -2-[4’-methoxyphenyl] ethane and 2-oxime-1-hydroxy, 1-[2-chlorophenyl]-2-[4’- methoxyphenyl] ethane (HA) derivatives were synthesized by benzoin condensation and followed by addition reaction to find a potential anti-oxidant agent.

Materials and Methods:

Qualitative analyses were determined by FT-IR and FT-NMR studies. Antioxidant activities were tested by DPPH assay, ABTS assay, and FRAP assay H2O2 methods.

Results:

From the obtained results, it is confirmed that the effect of withdrawing and electron releasing groups as a substituent in the core structure of parent compounds enhances the activity of antioxidant. The role of substituents is discussed in detail.

Conclusion:

The results of the biochemical assay reveal that the synthesized compounds serve as good free radical inhibitors and scavengers, which inhibit the oxidative reactions, and are responsible for cell damage, food spoilage, etc. The promising anti-oxidant activities are because of the effective substituents which play a prominent role in the drug industries.
Efficacy of Anti-VEGF Drugs Based Combination Therapies in Recurrent
Glioblastoma: Systematic Review and Meta-Analysis
Authors: Solipuram Vinod , Soltani Ramin , Venkatesulu BP , Annam Saketh , Alavian Firoozeh , Ghasemi Sorayya
Published: May 2022

Background:

Recurrent glioblastoma multiforme (rGBM) has a grim prognosis, with current
therapies offering no survival benefit. Several combination therapies involving anti-VEGF agents
have been studied with mixed results.

Methods:

A systematic search was performed using five electronic databases: PubMed, Scopus, ISI,
Embase, and the Cochrane Library, without language limitations. The primary outcome of interest was
progression-free survival (PFS). Secondary outcomes were overall survival (OS), objective response
ratio (ORR), and grade ≥ 3 adverse events. Estimates for PFS and OS were calculated as random effects
hazard ratio (HR) with 95% confidence intervals (CIs) using the generic inverse variance method.
Estimates for ORR and grade ≥ 3 adverse events were calculated using a random-effects risk ratio
(RR) with 95% confidence intervals (CIs) using the Mantel-Haenszel method.

Results:

Thirteen studies met the inclusion criteria and a total of 1994 patients were included in the
analysis. There was no statistically significant improvement in PFS (HR 0.84; 95% CI (0.68, 1.03);
I2=81%), OS (HR 0.99; 95% CI (0.88, 1.12); I2=0%), and ORR (RR 1.36; 95% CI (0.96, 1.92);
I2=61%) in the combination therapy group when compared to the control group. Significantly higher
grade ≥ 3 adverse events (RR 1.30; 95% CI (1.14, 1.48); I2=47%) were seen in the combination therapy
when compared to the control group.

Conclusion:

Our analysis showed that the use of combination therapy with anti-VEGF agents did not
offer any benefit in PFS, OS, or ORR. In contrast, it had significantly higher grade 3-5 adverse events.
Further studies are needed to identify effective therapies in rGBM that can improve survival.
A Comprehensive Approach of Transitional Justice to Address the Deliberate Destruction of Cultural Heritage
Authors: Dey Shuvra
Published: May 2022

Given the fact that cultural heritage has been the subject of multi-dimensional crimes during or in the aftermath of armed conflicts, this article attempts to analyze why and how such crimes can be brought under transitional justice (hereinafter TJ) mechanisms. It starts with the challenge to ascertain the inbuilt relationship, importantly, how cultural heritage enters into the domain of TJ. To this end, it fragmentises the rights of heritage and laws associated with these rights and examines how multiple discourses (i.e. human rights, humanitarian law, and criminal law) come together to form the notion of heritage rights and how their recognition contributes to cultural heritage’s entrance into TJ project. Thereafter, it assesses the resonance of potential TJ mechanisms and elucidates how they can help reveal the truth concerning crimes against heritage, bring the perpetrators to justice, rehabilitate the destructed sites, redress the victims, and prevent future attacks. It reiterates the value of four measures widely accepted in the TJ discourse, namely, truth-seeking, prosecution, reparations, and the measures of guarantees of non-recurrence. Finally, it explains why a comprehensive approach in terms of implementing these measures is essential and how such approach facilitates taking into account all the factors associated with the crimes against heritage.
Implementation of Virtual Reality in Health Professional Higher Education: Protocol for a Scoping Review
Authors: Lie Silje Stangeland , Helle Nikolina , Sletteland Nina Vahl , Vikman Miriam Dubland , Bonsaksen Tore
Published: May 2022

Background

The use of virtual reality in higher education show great potential to promote novel and innovative learning experiences. Until recently, virtual reality has mostly been used in technical higher education, but lately medical education programs have begun using virtual reality. Virtual reality for health professional education improves the knowledge and skills of health professionals compared with traditional or other digital education initiatives. However, the implementation of technology in higher education is slow because of barriers to technology use and innovative and successful practices are not shared. It is, therefore, of great interest to explore how virtual reality is implemented in higher health professional and continuing education.

Objective

The aim of this scoping review is to identify studies that reported implementation of virtual reality in higher health professional education, to identify barriers and facilitators for implementation, and to highlight research gaps in this area.

Methods

The scoping review will be conducted according to JBI Evidence Synthesis methodologies. CINAHL, the Academic Search Elite and Education Source electronic databases, and Google Scholar will be searched for studies published between 2017 and 2022. In addition, manual searching of key items, reference tracking, and citation tracking will be performed. Searches for white papers will also be manually conducted. All authors will independently extract data from full-text papers. We will use qualitative content analysis to abstract the findings.

Results

The literature searches were conducted in January and February 2022. The review is expected to be completed by fall 2022, after which time it will be submitted for publication.

Conclusions

We anticipate that, from the review, we will be able to coordinate recommendations for and present the challenges of virtual reality initiatives in health professional education programs. We will present recommendations for future research.

International Registered Report Identifier (IRRID)

DERR1-10.2196/37222
Deconstructing TikTok Videos on Mental Health: Cross-sectional, Descriptive Content Analysis
Authors: Basch Corey H , Donelle Lorie , Fera Joseph , Jaime Christie
Published: May 2022

Background

Social media platforms that are based on the creation of visual media, such as TikTok, are increasingly popular with adolescents. Online social media networks provide valuable opportunities to connect with each other to share experiences and strategies for health and wellness.

Objective

The aim of this study was to describe the content of the hashtag #mentalhealth on TikTok.

Methods

This cross-sectional, descriptive content analysis study included 100 videos with the hashtag #mentalhealth on TikTok. All videos that included the hashtag #mentalhealth were analyzed and coded for the presence of content categories. Additionally, the comments to each video were viewed and coded for content in the following themes: offering support or validation; mentioning experience with suicide or suicidal ideation; mentioning experience with self-harm; describing an experience with hospitalization for mental health issues; describing other mental health issues; and sharing coping strategies, experiences of healing, or ways to feel better.

Results

Collectively, the 100 videos studied received 1,354,100,000 views; 266,900,000 likes; and 2,515,954 comments. On average, each video received 13,406,930.69 (SD 8,728,095.52) views; 2,657,425.74 (SD 1,449,920.45) likes; and 24,910.44 (SD 21,035.06) comments. The only content category observed in most (51/100, 51%) of the videos included in the sample was “general mental health.” The remaining content categories appeared in less than 50% of the sample. In total, 32% (32/100) of the videos sampled received more than the overall average number of likes (ie, more that 2.67 million likes). Among these 32 videos, 23 (72%) included comments offering support or validation and 20 (62%) included comments that described other mental health issues or struggles.

Conclusions

With over 1 billion cumulative views, almost half of the assessed TikTok videos included in this study reported or expressed symptoms of mental distress. Future research should focus on the potential role of intervention by health care professionals on social media.
Клінічний випадок анестезіологічного забезпечення пацієнтів при реконструктивних операціях з приводу облітеруючого атеросклерозу нижніх кінцівок з низькою фракцією викиду лівого шлуночка
Authors: Masudi A.V. , Dziuba D.O. , Chkhaidze O.T. , Loskutov O.A.
Published: May 2022

Низька фракція викиду часто є супутньою патологією при облітеруючому атеросклерозі нижніх кінцівок у літніх людей, які звертаються за анестезіологічною допомогою, та складним викликом для анестезіолога через підвищений ризик періопераційних ускладнень. Комбінований ризик низької фракції викиду і поганий серцевий резерв можуть призвести до збільшення періопераційної смертності при реконструктивних операціях з приводу облітеруючого атеросклерозу нижніх кінцівок. У цій статті проведено аналіз подібного клінічного випадку з порівнянням тактики анестезіологічного менеджменту зі світовою практикою. Розбір клінічного випадку та його аналіз показує, що нейроаксіальні методи та регіональні блокади дають кращі результати у пацієнтів із серцево-судинними захворюваннями, які перенесли некардіологічні операції, порівняно із загальною анестезією.
Lean Technology in Construction
Authors: Khopade Mohini Ashok , Desale Dr. Sunil Vikram
Published: May 2022

Abstract: Since the 1940’s, lean production principles have evolved and were successfully implemented by Toyota Motor Company. Lean construction is a production and management-based approach to a project. An increasing number of construction academics and professionals are storming the ramparts of conventional construction management in an attempt to deliver better value to owners while making real profits. As a result, lean-based tools have emerged and are successfully applied to simple and sophisticated construction projects. Generally, lean construction projects are easier to manage, safer, completed sooner, cost less and are of higher quality. Thanks to the success of the lean production system in manufacturing the construction industry has adapted lean techniques to eliminate waste and increase profit. It is a way to design production system to minimize the wastage of material, time, and effort in order to generate the maximum possible amount of value. The main objective of this study is to analyze and implement the lean construction practices. Keywords: lean construction, economic, safe, construction management
Automated Pressing Machine
Authors: Rote Ajinkya M. , Harode Aishwarya S. , Chaware Diksha B. , Chavhan Shivani P. , Katole Mohit K. , More Roshan R.
Published: May 2022

Abstract: The paper presents the development of a automatic operated compress which encompasses the design, fabrication and performance evaluation of the press. The components parts of the machine were designed using various design equations. The design results were used to select materials for various components. The detailed drawing of the developed machine was done using solid works software. In fabricating the machine, mild steel was used as the locally sourced material. The use of mild steel is due to the fact that its strength, rigidity and machinability falls within the design specifications. Some components of the machine developed include; the frame, working bed, and buttons (on / off ). Some of the bought out parts include: ram assembly, rotaey motor, pressure indicator. Here the automation of a pressing machine using electric rotary motor. Generally, the manual operation of the pressing machine is automated. The main objective is to reduce man power, cost, production time and to increase the quantity and quality of production. The existing system of pressing process are manual controlling of pressing and unloading and the chance of human errors and production time are more. In order to overcome these errors, we have designed this electric rotary machine pressing . The automatic press machines that are incorporated with a electric rotary motor are made for heavy-duty pressing operations. In a heavy-duty pressing operation, the production is bulky and precision is required.
Moral Education in View of Al-Ghazali and Emile Durkheim
Authors: Indriyani Dian , Ishomuddin Ishomuddin
Published: May 2022

Modern society is familiar with capitalism and the rationalization of social relations. Today, they face a complicated problem related to social identity. Atomistic, impersonal and competitive society in the market and capitalism cause society does not find their individual identity in social identity. This study aimed to determine the views of Al-Ghazali and Emile Durkheim about the differences and similarities of moral education as well as the relevance of the two figures’ thoughts. This study used the Library Research type. The data collection used primary and secondary sources. Data are analyzed using historical, descriptive, analytical and comparative methods. The results indicate that moral education based on Al-Ghazali's view is to configure humans who are saintly to get closer to God. The sources of al-Ghazali’s moral education are revelation and strict guidance from the sheikh so it does not optimize the function of reason. Meanwhile, moral education of Emile Durkheim is a social means to realize social goals. The purpose of moral education is the creation of social solidarity and social equilibrium in society.
Course of COVID-19 in patients with HIV infection and morphological changes in the lungs with a combined damage SARS-CoV2 and secondary infections
Authors: Kapustin D. V. , Krasnova E. I. , Khokhlova N. I. , Shishkova O. M. , Ulyanova Ya. S. , Tyryshkin A. I.
Published: May 2022

The purpose statement is to study the course of COVID-19 in patients with HIV infection and morphological changes in the lungs with their combined SARS-CoV-2 and secondary infections.

Materials and methods: The study included 96 patients with HIV infection and SARS-CoV-2 infection confirmed by PCR, aged 26 to 54 years. The clinical manifestations, the content of CD4-lymphocytes and HIV RNA, the presence of secondary infections, and morphological changes in the lungs were studied.

Results and discussion: In patients with HIV infection with moderate or severe immunodeficiency, a mild course of COVID19 (63.2%) was observed more often than in patients without immunodeficiency (14.3%). Four out of 9 patients with severe immunodeficiency developed a combined lesion of the lung tissue (SARS-CoV-2 + CMV and SARS-CoV-2 + Pneumocystis carinii) with a fatal outcome.

Conclusion: In the diagnosis and treatment of COVID-19 in patients with HIV infection, it is necessary to take into account the severity of immunodeficiency and viral load.