bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinants of breast cancer prevention in a group of women with cancer suspicion
Authors: Kwilosz Edyta , Grzesik-Gąsior Joanna , Dobrowolska Patrycja
Published: March 2024

Wstęp

W związku ze stałym wzrostem zachorowalności na raka sutka na świecie coraz ważniejsze staje się monitorowanie działań profilaktycznych oraz zwiększanie prozdrowotnej świadomości społeczeństw w zakresie nowotworów piersi, szczególnie w grupie osób, u których prawdopodobieństwo wystąpienia problemu onkologicznego jest duże. Celem badania była analiza wybranych czynników determinujących podejmowanie przez kobiety działań w zakresie profilaktyki raka piersi.

Materiał i metody

Badanie prowadzono metodą sondażu diagnostycznego wśród 121 kobiet, pacjentek poradni onkologicznej Podkarpackiego Ośrodka Onkologicznego w Brzozowie. Ocenie poddano wiedzę kobiet, wskaźniki socjodemograficzne oraz dodatni wywiad rodzinny w kierunku raka piersi. Narzędzie stanowił autorski kwestionariusz ankiety. Do weryfikacji hipotez wykorzystano test chi-kwadrat (χ2). Przyjęto poziom istotności p < 0,05.

Wyniki

Najczęstszym źródłem wiedzy na temat profilaktyki raka piersi był Internet (52,89%), a głównym powodem rezygnacji z badań profilaktycznych brak świadomości o zagrożeniu, jakie niesie ze sobą choroba (38,84%). U ponad 30% badanych stwierdzono niski poziom wiedzy, który był zróżnicowany statystycznie w zależności od wykształcenia (p < 0,001) oraz wieku badanych (p = 0,01). Kobiety młodsze oraz lepiej wykształcone wykazywały wyższy poziom wiedzy, który był związany z regularnością podejmowanych działań profilaktycznych (p = 0,048) oraz wykonywaniem samobadania piersi (p < 0,001). Wystąpienie raka piersi w rodzinie miało wpływ na regularność samobadania oraz wykonywanie badań diagnostycznych w kierunku raka piersi (p < 0,001).

Wnioski

Poziom wiedzy na temat profilaktyki raka piersi w badanej grupie nie był w pełni zadowalający i wymaga uzupełnienia. Wskazanie przez kobiety Internetu jako głównego źródła wiedzy wskazuje na konieczność zwiększenia udziału specjalistów medycznych w edukacji onkologicznej. Najważniejszymi predyktorami regularnie podejmowanych działań profilaktycznych są młody wiek, wyższy poziom wiedzy, wyższe wykształcenie oraz dodatni wywiad rodzinny (nowotwór piersi).
Bio-efficacy of Xanthium strumarium L. Essential Oil against Castor Semilooper, Achaea janata L. (Lepidoptera: Noctuidae)
Authors: Shindez Anuradha K. , Parchande Rohit S. , Yankanchi S.R.
Published: March 2024

Background: Although use of synthetic insecticides causes excellent control of insect pests, it leads to adverse effects on non-target organisms as well as the environment. The present study determining the chemical composition and insecticidal activities of essential oil extracted from the leaves of rough cocklebur, Xanthium strumarium and its bioefficacy against the castor semilooper, Achaea janata shall show a new dimension in formulating an ecofriendly management strategy towards castor crop. Methods: Xanthium strumarium leaf essential oil was isolated through hydro-distillation method using Clevenger apparatus and the chemical composition was analysed using GC-MS. The ovicidal and insecticidal activity of the essential oil was determined by dipping and topical application methods, respectively. Larval feeding deterrence and growth inhibitory properties of the essential oil was evaluated through the diet incorporation method. Result: GC-MS analysis of the X. strumarium essential oil revealed the presence of 14 chemical compounds, of which the majority are the terpenes (94.48%). The LC50 values in terms of ovicidal and insecticidal activities were recorded to be 69.70 µL/mL and 0.30 µL/larvae, respectively. The fifty per cent larval feeding deterrence (DC50) and growth inhibitory properties (EC50) were recorded to be 1.88 µl/cm² and 213.94 µL/mL, respectively.
The Role of Games in the Moral Education of Children from an Islamic Perspective
Authors: Abedi Renani Ali , Brahman Maryam
Published: March 2024

In this article, we will examine moral education through games from an Islamic perspective. To this end, we will first present a discussion of virtue ethics as the theoretical framework of our discussion since a major part of Islamic moral education can be explained through it. As we will explain, virtue ethics emphasizes the effect of following moral patterns in character formation. Then, we will discuss the place of games in the moral education method of the Prophet of Islam and the Shia Imams and show how they paid attention to the moral education of children through games. We will then look at some new games designed by Islamic education experts for this purpose. Finally, we will discuss some theoretical mechanisms to explain the efficacy of these games and examine an empirical case study conducted in this field.
Research Objectives: To explore the role of games in the moral education method of the Prophet of Islam and the Shia Imams.
Research Methods: A qualitative documentary method to study the place of games in Islamic moral teachings and methods.
Research Results: A major part of Islamic moral education can be explained through the virtue ethics framework, which emphasizes the effect of following moral patterns in character formation.
YETİŞKİN BİREYLERİN KORONAVİRÜS (COVID-19) SALGINI İLE BAŞA ÇIKMA SÜREÇLERİ: KARMA BİR ARAŞTIRMA
Authors: Aktu Yahya
Published: March 2024

Bu araştırmanın amacı yetişkin bireylerin Koronavirüs salgını (COVID-19) ile başa çıkma süreçlerinin nasıl olduğunu ortaya koymaktır. Araştırma açıklayıcı sıralı karma desen ekseninde yürütülmüştür. Katılımcılar iç içe karma örneklem yöntemiyle belirlenmiştir. Araştırmanın nicel boyutundaki katılımcılar 672 yetişkin bireyden ve nitel boyutundaki katılımcılar 44 yetişkin bireyden oluşmaktadır. Verilerin toplanmasında ardışık veri toplama yöntemi tercih edilmiştir. Veriler Salgınla Başa Çıkma Ölçeği ve Yarı-Yapılandırılmış Görüşme Formu ile toplanmıştır. Verilerin analizinde ardışık veri analizi yöntemi kullanılmıştır. Nicel verilerin analizinde bağımsız örneklem t-testi ve tek yönlü varyans analizi (ANOVA), nitel verilerin analizinde tematik analiz ve karma verilerin analizinde harmanlama yöntemleri kullanılmıştır. Nicel bulgular; kadınların, evli bireylerin, 26-39 yaş arasındaki yetişkin bireylerin, kronik bir hastalığı olmayan yetişkin bireylerin, lise ve üniversite mezunu yetişkin bireylerin salgınla başa çıkma üzerinde önemli bir role sahip olduğunu göstermiştir. Nitel bulgular; yetişkin bireylerin salgını fark etme sürecinde duygusal, bilişsel ve davranışsal tepkiler verdiklerini ortaya koymuştur. Salgınla başa çıkma sürecinde ise, yetişkin bireylerin bakış açılarını değiştirme, sosyal destek arama, manevi destek arama ve uğraş edinme yollarını kullandıkları anlaşılmaktadır. Nitel bulguların nicel sonuçları desteklediği ve yeterince açıkladığı sonucuna ulaşılabilir. Nicel ve nitel yöntemle elde edilen veriler ışığında, yetişkin bireylerin bilişsel başa çıkma (bakış açılarını değiştirme), aşkın başa çıkma (manevi destek arama), davranışsal başa çıkma (uğraş edinme) ve ilişkisel başa çıkma (sosyal destek arama) yöntemlerini kullandıkları söylenebilir.
Analisis PERPRES Nomor 55 Tahun 2019 Terkait Program Kendaraan Listrik Dalam Rangka Mewujudkan Transportasi Ramah Lingkungan
Authors: Subiantoro Hernowo , Maharani Andina Elok Puri
Published: March 2024

ABSTRACT
The emergence of environmental issues and the fossil-based energy crisis has encouraged the development of environmentally friendly transportation. The purpose of the research is to analyze whether Presidential Regulation Number 55 of 2019 has been able to realize the acceleration of environmentally friendly transportation and the ideal policy related to the electric vehicle acceleration program. The type of research used is normative juridical with a statutory, and conceptual approach. The results showed that Presidential Regulation Number 55 of 2019 as the main legal instrument for the acceleration of the electric vehicle program is in fact not fully able to realize the acceleration of environmentally friendly transportation with indicators including the ambiguity of legal certainty because there is an antithesis between the reality that occurs and the desired expectations, a deeper study is needed regarding the most effective form of regulation in responsive positive law, and there is a gap for environmental damage (Jevons Paradox) as a result of the industrialization of electric vehicles. The ideal policy of environmentally friendly transportation is at least able to consistently realize good governance, create legal certainty, and authority based on laws and regulations.
 
Keywords: Affordable & Clean Energy, Electric Vehicles, Green Transportation.
 
 
ABSTRAK
Munculnya issu lingkungan dan krisis energi berbasis fosil telah mendorong berkembangnya transportasi ramah lingkungan. Tujuan penelitian untuk menganalisa keefektifan Perpres RI Nomor 55 Tahun 2019 untuk mewujudkan akselerasi transportasi yang ramah lingkungan dan bagaimana kebijakan ideal terkait program percepatan kendaraan Listrik. Jenis penelitian yang digunakan adalah yuridis normatif dengan pendekatan perundang-undangan, dan konseptual. Hasil penelitian menunjukkan bahwa Perpres Nomor 55 Tahun 2019 sebagai instrumen hukum utama percepatan program kendaraan listrik ini faktanya belum sepenuhnya mampu mewujudkan akselerasi transportasi ramah lingkungan dengan indikator antara lain ambiguitas kepastian hukum karena terjadi antitesis antara kenyataan yang terjadi dengan harapan yang diinginkan, diperlukan telaah lebih mendalam mengenai bentuk aturan paling efektif dalam hukum positif yang responsif, dan terdapat celah bagi terjadinya kerusakan lingkungan (Jevons Paradox) sebagai dampak industrialisasi kendaraan listrik. Kebijakan ideal transportasi ramah lingkungan setidaknya mampu secara konsisten mewujudkan tata kelola pemerintahan yang baik (good governance), terciptanya kepastian hukum,  dan kewenangan yang berdasarkan peraturan perundang-undangan.
 
Kata Kunci: Energi bersih & terbarukan, Kendaraan Listrik, Transportasi Ramah Lingkungan.
Kedudukan Barang Bukti Yang Diperoleh Secara Melawan Hukum Dalam Putusan Mahkamah Agung Nomor 1614 K/ Pid.Sus /2012
Authors: A. Zainur Rasyidi Ramadhani
Published: March 2024

Abstract
National Police of the Republic of Indonesia is a institution that has functions to provide protection to the society. For the implementation of enforcement law, investigator conducts inquiry and investigation as the first step of the whole law enforcement process. Unfortunately, police officers often obtain unlawful evidence during the investigation process in order to frame a suspect. Admissibility of Evidence is invalid. This situation make no chance for the framed suspect to fight for the rights. Indonesian criminal procedure law establishes “pretrial”court process which facilitate the supervision of the investigation process. Through the Decision of the Constitutional Court Number 21/PUU- XII/2014, there is an additional object to the pretrial process, that is the determination of the suspect. Through this decision, the party who is harmed by the police’s unlawful action will be able to conduct a pretrial legal effort in order to protect their rights on a fair investigation.
Keywords: Admissibility of Evidence, Unlawful, Legal Efforts, Pretrial.
 
Abstrak
Kepolisian Negara Republik Indonesia adalah salah satu lembaga penegak hukum yang berfungsi melakukan tindakan pencegahan terhadap terjadinya kejahatan dan memberikan perlindungan terhadap seluruh masyarakat. Demi terlaksananya hukum pidana dan hukum acara pidana, tindakan penyelidikan dan penyidikan yang dilakukan oleh kepolisian adalah sebagai langkah awal dalam proses penegakan hukum. Perolehan barang bukti secara melawan hukum seringkali dilakukan oleh polisi dalam penyidikan untuk mendapatkan tersangka. Kedudukan barang bukti tersebut patut untuk dipertanyakan. Keadaan kekurangan instrumen hukum membuat pelaku tersebut tidak terjamah dan tidak ada kesempatan bagi tersangka untuk memperjuangkan haknya. Hukum acara pidana Indonesia membentuk pranata praperadilan yang fungsinya sebagai wadah untuk melakukan pengawasan terhadap proses penyidikan. Melalui putusan Mahkamah Konstitusi Nomor 21/PUU– XII/2014, terdapat penambahan pada objek praperadilan yaitu penetapan tersangka. Melalui putusan ini, pihak yang merasa dirugikan terhadap perilaku polisi tersebut dapat melakukan upaya hukum praperadilan sehingga hak asasi manusia tersangka dapat terpenuhi.
Kata Kunci: Kedudukan Barang Bukti, Melawan Hukum, Upaya Hukum, Praperadilan.
Keberatan Pihak Ketiga Yang Beritikad Baik Terhadap Perampasan Aset Dalam Tindak Pidana Korupsi
Authors: Evander
Published: March 2024

Abstract
Evidence is an item of crime and one of the important pieces of evidence in uncovering a crime. Evidence is not always owned by the Defendant but is under the control of a third party with good intentions. This action violated the provisions of Article 28H paragraph (4) of the 1945 Constitution where third party property rights were taken by force. To respond to these problems, Article 19 paragraph (2) of the PTPK Law has protected third parties who have good intentions through “Keberatan” but there are limitations in submitting them so that they violate article 573 BW. The breach was resolved with the advent of PERMA 2/2022. PERMA 2/2022 stipulates that “Keberatan” can be filed based on a first level decision, appeal or cassation. The addition of norms in PERMA 2/2022 raises a problem where Article 19 paragraph (2) of the PTPK Law and PERMA 2/2022 are not aligned and there are legal issues, namely whether there is a conflict of norms.
Keywords: evidence, “PERMA 2/2022”, Article 19 paragraph (2) of the “PTPK” Law, “Keberatan”, third party with good intentions.
 
Abstrak
Barang bukti merupakan barang kejahatan dan salah satu alat bukti penting dalam mengungkap kejahatan. Barang bukti tidak selalu dimiliki oleh Terdakwa tetapi berada dibawah kekuasaan pihak ketiga yang beritikad baik. Tindakan tersebut melanggar ketentuan Pasal 28H ayat (4) UUD 1945 dimana hak milik pihak ketiga diambil secara paksa. Untuk menanggapi permasalahan tersebut, Pasal 19 ayat (2) UU PTPK telah melindungi pihak ketiga yang beritikad baik lewat upaya Keberatan tetapi terdapat batasan dalam mengajukannya sehingga melanggar pasal 573 BW. Pelanggaran tersebut diselesaikan dengan munculnya PERMA 2/2022. PERMA 2/2022 mengatur bahwa Keberatan dapat diajukan berdasarkan putusan tingkat pertama, banding atau kasasi. Penambahan norma dalam PERMA 2/2022 tersebut menimbulkan permasalahan dimana pasal 19 ayat (2) UU PTPK dengan PERMA 2/2022 tidak selaras dan terdapat isu hukum, yakni apakah terjadi konflik norma.
 Kata Kunci: barang bukti, PERMA 2/2022, pasal 19 ayat (2) UU PTPK, Keberatan, pihak ketiga yang beritikad baik
Hak Dan Kewajiban Alimentasi & Hadlhanah Anak Luar Kawin Pasca Putusan Mahkamah Konstitusi No.46/PUU-VIII/2010
Authors: Nadila Manda Sari
Published: March 2024

AbstractIn Islam, it teaches the existence of hadlhanah, which is the term given to the rights and obligations to care for a child she is carrying, which is borne by the mother. However, in the development of law in Indonesia, the Constitutional Court Decision Number 46/PUU-VIII/2010 was born which gave real legal status to illegitimate children with their fathers. In research that uses a contextual approach and a case approach through analysis of the judge's considerations in the Constitutional Court Decision Number 46/PUU-VIII/2010, it is explained that the decision confirms that there is a legal relationship between an illegitimate child and his biological father. The inherent relationship between the two of them takes the form of a civil legal relationship and obligations attached to the father towards the illegitimate child.
Keywords: Alimentation, Hadlanah, Illegitimate Children.
 
Abstrak
Dalam Islam mengajarkan adanya hadlhanah yang mana sebutan ini diberikan kepada hak serta kewajiban untuk memelihara seorang anak yang dikandungnya yang mana hal ini dibebankan kepada ibu. Akan tetapi, dalam perkembangan hukum di Indonesia lahirlah Putusan Mahkamah Konstitusi Nomor 46/PUU-VIII/2010 yang memberikan kedudukan hukum nyata bagi anak luar kawin dengan ayahnya. Dalam penelitian yang menggunakan pendekatan kontekstual serta pendekatan kasus melalui analisa pertimbangan hakim dalam Putusan Mahkamah Konstitusi Nomor 46/PUU-VIII/2010 ini, dijelaskan bahwa dalam keputusan tersebut menegaskan bahwa adanya hubungan hukum seorang anak luar kawin dengan ayah biologisnya. Hubungan yang melekat diantara keduanya ini berbentuk hubungan hukum keperdataan dan kewajiban yang melekat di ayah kepada anak di luar kawin tersebut.
Kata Kunci: Alimentasi, Hadlanah, Anak Luar Kawin.
TRANSFORMATION OF THE IMAGE OF AN OLD MAN IN THE MINDS OF YOUNG SPEAKERS OF RUSSIAN LINGUISTIC CULTURE
Authors:   Peoples’ Friendship University of Russia named after Patrice Lumumba, Denisenko V.N. , Safaralieva L.A. ,   Peoples’ Friendship University of Russia named after Patrice Lumumba, Perfilieva N.V. ,   Peoples’ Friendship University of Russia named after Patrice Lumumba
Published: March 2024

The purpose of this article is to model the image of an old man in Russian linguistic culture, that is, to identify the conceptual, figurative and value features of the OLD AGE concept, verbalized by the old man lexeme. The main research methods are: conceptual and definitional analysis of the old man lexeme based on the material of lexicographic sources and reconstruction of associative-verbal networks of the lexeme-verbalizer of the concept; the analytical algorithm also includes the method of free associative experiment. The study revealed significant changes in the consciousness of young Russian speakers in perceiving of the old man stimulus. Semantic transformations primarily affected the value and figurative signs of an old man, namely: reactions describing the appearance of an elderly person became frequent: a gray-haired grandfather with a beard leaning on a cane. It was also found that in the minds of young speakers of Russian linguistic culture, the old man appears to be a kind, weak, sick, lonely person in need of help from others. Russian linguistic culture speakers’ consciousness can be penetrated by the results of the study and the potential associative characteristics of a significant fragment of the Russian linguistic world view can be reconstructed.
The feeling of love in the metaphorical space of the Russian language: core mappings AND MODELS
Authors:   Ural Federal University named after the First President of Russia B.N. Yeltsin, Babenko L.G. , Romanova M.A. ,   Ural Federal University named after the First President of Russia B.N. Yeltsin
Published: March 2024

The authors analyze the metaphorical representation of love basing their observations on dictionary data. The object of the study is the metaphorical lexicon of love (249 items, 37% of the total amount of words related to the semantics of love). The subject of the study is the regular metaphorical mappings of the feeling of love and their categorization in relation to the source domain, which serves as a basis for further classification of metaphorical models (M-models). The goal of the study is to identify metaphorical mappings of the feeling of love, to define the structure of denotative ideographic spheres and groups that fill the position of the source domain and form the metaphorical representation of love. The authors suggest an analysis algorithm that consists of the following steps: 1) collection of the corpus of love metaphors; 2) categorization of the words with metaphorical meanings; 3) identification of the core M-models and regular metaphorical mappings; 4) statistical description of the M-models in the “field” format; 5) interpretation of the metaphorical representation of love. The authors conducted paradigmatic analysis of the thematic groups serving as the source domain of the metaphors of love and identified 10 metaphorical mappings on the supercategorical level and 44 M-models on the level of basic categories. As a result, the structure of the metaphorical space has been arranged with regards to the priorities of the metaphorical mappings, and the inventory of the M-models has been itemized. The metaphorical space of love is demonstrated to be polycentric, with the bulk of it being formed by the lexical groups belonging to the denotative spheres of “Concrete Physical Activity”, “Inanimate Nature”, “Public and State”, “Animate Nature”, “Supernatural”. The lexical content of the M-models demonstrates the priorities of filling specific fragments of the metaphorical representation of love.
SYMBOLIZATION OF DESERT IN LINGUISTIC CONSCIOUSNESS
Authors:   Pushkin State Russian Language Institute, Karasik V.I. , Kitanina E.A. ,   Pushkin State Russian Language Institute
Published: March 2024

The paper deals with symbolization of nature focusing the evaluative characteristics of natural phenomena in utilitarian, ethical and aesthetic dimensions. From a utilitarian point of view the following ideas come to the fore: physical properties (size, temperature, ingredients, etc.), possible danger and useability of the corresponding object. The utilitarian properties of desert are reflected in dictionary definitions, reactions of informants, and descriptions of its climatic, geographical and biological characteristics. Ethical conceptualization of a natural phenomenon is a transfer of its characteristics to human behavior and allegoric evaluative comparison of such behavior and a certain natural object. It is expressed in proverbs and aphorisms with images of lifeless space, oases and mirages as a contrast between reality and dream, distortion of reality and deceptiveness of illusions. Ethically, the idea of a desert as a punishment for sins is often promoted in religious texts. Aesthetic symbolization of nature is manifested in linguistic consciousness as admiration of the beauty of the world or as awe and rejection of reality. Aesthetic symbolization of desert consists in contrast of light and darkness, spiritual emptiness and search of one’s destination, vanity and solitude. A special emphasis is given to an image of a spring in the desert.
INTERPRETIVE POTENTIAL OF THE COMPARISON FRAME
Authors:   Derzhavin Tambov State University, Blokhina E.D.
Published: March 2024

Comparison is a cognitive and linguistic mechanism of secondary linguistic interpreting compare concepts within one or different conceptual and thematic areas to highlight a certain characteristic/feature. The existence of a basic comparison model indicates that comparison is a stereotypical situation that is stored in a person’s memory in the form of a frame. The purpose of this article is to describe the interpretive nature of the comparison frame through the characteristics of its elements. In language, comparison appears in a truncated form, most often without subject and predicate. To reveal the interpretative essence of comparison, it is necessary to turn to the concept SIMILARITY, which represents the cognitive basis of comparison. It includes several types: physical, structural, functional, associative. The conflict of comparison is especially evident when it is used to emphasize signs of physical perception (shape, color, size) with an additional negative evaluative value. At the linguistic level, comparison is presented in several ways: lexical, word-formative, morphological.
A Machine Learning-Assisted Classification Algorithm for the Detection of Archaeological Proxies (Cropmarks) Based on Reflectance Signatures
Authors: Agapiou Athos , Gravanis Elias
Published: March 2024

Detection of subsurface archaeological remains using a range of remote sensing methods, poses several challenges until today. Recent studies regarding the detection of archaeological proxies like those of cropmarks highlight the complexity of the phenomenon. In this work we present three different methods, and associated indices, for identifying stressed reflectance signatures indicating buried archaeological remains, based on a dataset of measured ground spectroradiometric reflectance. Several spectral profiles between the visible and near infrared part of the spectrum, were taken over a controlled environment in Cyprus during the 2011-2012 and are re-used in this study. The first two (spectral) methods are based on a suitable analysis of the spectral signatures in (1) the visible part of the spectrum, and in particular in the neighborhood of 570 nm, and (2) the red edge-near infrared part of the spectrum, in the neighborhood of 730 nm. Machine learning (decision trees) allows for the deduction of suitable wavelengths to focus on, in order to formulate the proposed indices and the associated classification criteria (decision boundaries) that can enhance the detection probability of stressed vegetation. Noise in the signal is taken into account by simulating reflectance signatures perturbed by white noise. Applying decision tree classification on the ensemble of simulations and basic statistical analysis we refine the formulation of the indices and criteria for the noisy signatures. The success rate of the proposed methods is over 90%. The third method rests on the estimation of vegetation/canopy reflectance parameters through inversion of the physical-based PROSAIL reflectance model and the associated classification through machine learning methods. The obtained results provide further insights into the formation of stress vegetation that occurred due to the presence of shallow buried archaeological remains, which are well aligned with physical-based models and existing empirical knowledge. To the best of the authors' knowledge, this is the first study demonstrating the usefulness of radiative transfer models such as PROSAIL for understanding the formation of cropmarks. Similar studies can support future research directions towards the development of regional remote sensing methods and algorithms if systematic observations are adequately dispersed in space and time.
Cognitive, neuropsychological and biological effects of Oxygen-Ozone Therapy in frailty: a 5-week, randomized, placebo-controlled trial
Authors: Scassellati Catia , Bonvicini Cristian , Ciani Miriam , Zanardini Roberta , Tomasoni Evita , Saletti Valentina , Passeggia Ilaria , Almici Monica , Pagnoni Ilaria , Galoforo Antonio Carlo , Costa Mario , D’Onofrio Mara , Cattaneo Antonino , Geroldi Cristina
Published: March 2024

As the world’s population age, Cognitive Frailty (CF) is becoming one of the most serious health problems and elucidating its biological mechanisms along with prevention and treatments becomes increasingly important also considering the associated health costs. This pilot study aims to investigate the potential cognitive and neuropsychological effects of a 5-week treatment with a therapy based on the regenerative properties of ozone (O3) in a cohort of patients stratified according to CF. We also study the potential effects of O3 on blood-based biomarkers indicative of specific biological systems that may be altered in CF. Seventy-five older persons have been recruited and randomly assigned to receive the active treatment (150cc of oxygen-O2-O3 mixture at the concentration of 30ug of O3 per cc of O2) or O2, or the placebo (air) for 5 weeks. The primary endpoint is a change in the scores of clinical scales from baseline (T0) to weeks 3 (T3), 9 (T9), 15 (T15) after treatment. The secondary endpoint is a change in biomarkers levels resulting from transcriptomics, proteomics and metabolomic patterns at the same times. This study will evaluate whether an intervention with the O2-O3 therapy could have potential cognitive, neuropsychological and biological effects on CF.
Microcurrent Therapy Mitigates Neuronal Damage and Cognitive Decline in an Alzheimer's Disease Mouse Model: Insights into Mechanisms and Therapeutic Potential
Authors: Kim Eun Ho , Lee Won Seok , Kwon Dong Rak
Published: March 2024

Alzheimer's Disease (AD) presents a significant challenge in the wake of its multifaceted nature, characterized by cognitive decline, memory impairment, and neuroinflammation. Despite extensive research, effective pharmacological interventions remain elusive, prompting exploration into non-pharmacological approaches. Microcurrent therapy (MC), utilizing imperceptible currents, has emerged as a potent clinical protocol. While previous studies have focused on its therapeutic effects, this study investigates its impact on neuronal damage and neuroinflammation in an AD mouse model, specifically addressing potential side effects. Utilizing 5xFAD transgenic mice, we examined the effects of MC therapy on neuronal integrity and inflammation. Our findings suggest that MC therapy attenuates memory impairment and reduces neurodegeneration, as evidenced by improved performance in memory tests and preservation of neuronal structure. Additionally, MC therapy significantly decreases amyloid-beta (Aβ) plaque deposition and inhibits apoptosis, indicating its potential to mitigate AD pathology. Our study discovered that MC therapy effectively reduces glial activation by inhibiting the TLR4-MyD88-NFκB pathway, consequently leading to decreased levels of inflammatory factors TNF-α, IL-1β, and IL-6, thus implicating TLR4 in neurodegenerative disease-related neuroinflammation. Furthermore, while our study did not observe significant adverse effects, further clinical trial into potential side effects and neuroinflammatory responses associated with MC therapy is warranted.
Closing the Gap: The Tripartite Structure of Sustainability as a Tool for Sustainable Education— A Systematic Literature Review
Authors: Meyer Barbara E. , Gaertner Elena , Elting Christian
Published: March 2024

(1) In an era where sustainable behavior is increasingly crucial, understanding the discrepancy between individuals' sustainability-oriented values and their actual behaviors, known as the inner-outer gap, is vital. This study explores the potential of the Tripartite Structure of Sustainability (TSS) framework to address this gap within the context of sustainable education. By reviewing literature from the databases APA, ERIC, and Web of Science, we systematically examined factors influencing sustainable actions. (2) Employing a qualitative content analysis approach, we analyzed 56 articles over a 15-year period, identifying 83 factors that either bridge or reinforce the inner-outer gap. These factors were categorized within the TSS framework, which segments sustainability-oriented actions into individual, social, and self-transcendent domains, alongside their activation points: stable, situational, or automated. (3) Our analysis revealed that self-focused factors often reinforce the gap, suggesting a hindrance to sustainable behavior. Conversely, self-transcendent factors consistently bridged the gap, promoting sustainability. Social factors showed variable impacts based on the ethical and sustainable context they were placed in, suggesting that the social environment's orientation significantly influences sustainable behavior. (4) The study concludes that the TSS framework offers a promising approach to advancing sustainability in education by facilitating a paradigm shift towards holistic and interconnected perspectives. This shift is critical for fostering sustainable behaviors, thereby contributing to the field of educational psychology and offering practical implications for educators aiming to nurture a sustainable future.
Planetary Energy Flow and Entropy Generation Rate by Earth from 2002 to 2023
Authors: Thimsen Elijah
Published: March 2024

In this work, satellite data from the Clouds and Earth’s Radiant Energy System (CERES) and Moderate Resolution Imaging Spectroradiometer (MODIS) instruments is analyzed to determine how the global absorbed sunlight and global entropy generation rate have changed during the time period from 2002 to 2023. The data is used to test hypotheses derived from the Maximum Power Principle (MPP) and Maximum Entropy Production Principle (MEP) about the evolution of earth’s surface and atmosphere. The results indicate that the amount of absorbed sunlight has increased over the last 20 years but rising surface temperatures have caused the entropy generation rate to remain approximately constant despite that decrease in albedo. The results are simpler to explain using the MPP but do not completely rule out the MEP. Given the acceptance of the MPP or MEP, some extensions and nuances are discussed.
Administration and Management of the Urban Transport Network by Means of Geographic Information Systems (GIS) Study of the City of Batna
Authors: Nourdine Anoune , Lyes Hadjira
Published: March 2024

The administration and management of urban transport has become an urgent need, in the context of the increasing congestion problems and the environmental and economic damage, resulting from rapid urban expansion witnessed by the Algerian cities in recent times, in order to achieve prosperity and quality of urban life. It became necessary to use the tools of modern technology, which administrative and technical departments are seeking to use primarily to support ways of decision-making and actions required. Boosted by high capabilities in the statistical data and other information is stored, and coordination and tabulation, with the possibility of installation and analysis by operations. Especially against the inability of traditional methods, which have become less able to cope with the changes that led to the urban dynamic currently experienced by urban communities in our country. This research aims to employ geographic information systems in the administration and management of the urban transport network, facing both the population and the local administration of the city of Batna. Which was chosen as a model for major Algerian cities, which is suffering more than ever of transportation bottlenecks, as well as the unintended damage for these networks and other networks. Hence the importance of the subject of our research, which aims to use GIS MapInfo systems as a means to snipe (Data Capture) and storage (Data Storage) and address (Data Processing) and directed by spatial information (Spatial Data) and link them to the descriptive information (Attribute Data). To develop a modern digital data and charts the base of each of these elements of the urban service lines equipment and mechanisms, ... etc. As a tool available to those creating and carrying out urban spaces, as well as decision-makers. It was concluded that the possibilities offered by this system would facilitate the processes of monitoring and management in order to ensure the quality of the service.
Synthesis of Co3O4 Nanoparticles through Solution Combustion Method and Their Applications: A Review
Authors: Hashami Muhammad - , Nazhipkyzy Meruyert , Seitkazinova Aigerim R. , Kerimkulova Almagul R. , Beisebayeva Aigul S. , Mashan Togzhan , Nurmukhanbetova Nurgul N.
Published: March 2024

Cobalt oxide nanoparticles are promising candidates for various kinds of practical application. The interest of researchers and scientists in these nanoparticles is due to their unique physical and chemical properties such as density, melting point, magnetic characteristics and band gap. The need to develop high performance and low-cost technologies for obtaining Co3O4 nanoparticles is a major reason in research in this area. The widespread commercial use of Co3O4 nanoparticles will open doors for numerous novel cost effective technologies, which are mostly dependent on the type of synthesis method and raw materials. A possible solution to this problem is to use Cobalt nitrates as a cost-effective precursor using the solution combustion method. Solution combustion synthesis method is one of the best candidate methods that have the potential for high performance and is also cost-effective. This review examines recent progress in the synthesis of Co3O4 nanoparticles by solution combustion method and underscores their significance across various fields, highlighting the need for further research and exploration of their multifaceted applications. In addition, the most recent advancements in the applications of Co3O4 nanoparticles in sensitive sensing, catalysis, supercapacitors/batteries and water treatment/pollutants removal are reviewed and described, focusing on current trends, challenges, and future outlooks.
Impact of Social Media Marketing Activities and ESG Green Brand Involvement on Green Product Repurchase
Authors: Hu Tung-Lai , Chao Chuang-Min , Lin Chia-Hung
Published: March 2024

Global warming, exacerbated by greenhouse gas emissions from non-green product manufacturing, necessitates a shift towards green production to safeguard ecosystems and finite resources. The United Nations Environment Programme emphasizes the importance of environmental considerations in corporate ESG criteria. Despite the higher costs of designing and manufacturing green products, which deter some companies and lead to greenwashing, efforts persist to promote sustainable goods. This study explores enhancing consumer repurchase intentions for green products through social media marketing, emphasizing green values, environmental concerns, brand image, and involvement. Findings reveal social media's role in boosting these factors, thus encouraging green repurchases. Insights are valuable for green businesses, social media groups, environmental agencies, and future research.
Development of PCR-Multiplex Assays for Identification of the Herpotrichiellaceae Family and Agents Causing Chromoblastomycosis
Authors: Sousa Gabriel S.M. , De Oliveira Rodrigo S. , De Souza Alex B. , Monteiro Ruan C. , Santo Elaine P. T. E. , Franco Filho Luciano C. , Moraes Denison L.O. , De Sá Sarah R. , Da Silva Silvia H. M.
Published: March 2024

The Herpotrichiellaceae family is an important group of dematiaceous filamentous fungi, associated with a variety of pathogenic fungal species causing Chromoblastomycosis (CBM) and Phaeohyphomycosis (PHM), both with polymorphic clinical manifestations and worldwide incidence. Currently, the identification of this family and determination of the causative agent is challenging due to the subjectivity of morphological identification methods, necessitating the use of molecular techniques to complement diagnosis. In this context, genetic sequencing of the Internal Transcribed Spacer (ITS) has become the norm due to a lack of alternative molecular tools for identifying these agents. Therefore, this study aimed to develop PCR-Multiplex methodologies to address this gap. Sequences from the ITS and Large subunit (LSU) of ribosomal DNA were used, and after manual curation and in vitro analyses, primers were synthesized for the identification of the aforementioned targets. The primers were optimized and validated in vitro, resulting in two PCR-Multiplex methodologies: one for identifying the Herpotrichiellaceae family and the bantiana clade, and another for determining the species Fonsecaea pedrosoi and Fonsecaea monophora. Ultimately, the assays developed in this study aim to complement other identification approaches for these agents, reducing the need for sequencing, improving the management of these infections, and enhancing the accuracy of epidemiological information.
Noradrenergic Transmission in the Basolateral Amygdala Mediates the Effects of Predatory Odor Exposure on Hippocampal Plasticity – a New Concept for Studying the Emotional Modulation of Memory Consolidation
Authors: Peshev Bogomil , Ivanova Petya , Krushovlieva Desislava , Kortenska Lidia , Atanasova Dimitrinka , Lazarov Nikolai , Tchekalarova and Jana
Published: March 2024

The pivotal role of the basolateral amygdala (BLA) in the emotional modulation of hippocampal plasticity and memory consolidation is well established. Specifically, multiple studies have demonstrated that the activation of the noradrenergic (NA) system within BLA governs these modulatory effects. However, most of the current evidence has been obtained by direct infusion of synthetic NA or beta-adrenergic agonists. In the present study, we aimed to investigate the effect of endogenous NA release in the BLA, induced by a natural aversive stimulus (coyote urine), on memory consolidation for a neutral hippocampal-dependent task. We combined a weak version of the object location task (OLT) with mild predator odor exposure (POE) for our experiments. To investigate the role of the BLA in memory modulation, a subset of the animals (Wistar rats) were treated with the non-selective beta-blocker propranolol at the end of the behavioral procedures. Hippocampal tissue was collected either 90 minutes after drug infusion or 24 hours after the OLT test. The samples were used to determine the levels of phosphorylated CREB (pCREB) and activity-regulated cytoskeleton-associated protein (Arc) - two molecular markers of experience-dependent changes in neuronal activity. The result suggests that POE is a behavioral paradigm suitable for studying the interaction between BLA and the hippocampus in memory prioritization and selectivity.
Cellular Response of Adapted and Non-Adapted Tetrahymena thermophila Strains to Europium Eu(III) Compounds
Authors: Alonso Patricia , Blas Javier , Amaro Francisco , De Francisco Patricia , Martin-Gonzalez Ana , Gutiérrez Juan Carlos
Published: March 2024

Europium is one of the most reactive lanthanides and humans use it in many different applica-tions, but we still know little about its potential toxicity and cellular response to its exposure. Two strains of the eukaryotic microorganism model Tetrahymena thermophila adapted to high concentrations of two Eu(III) compounds (EuCl3 or Eu2O3) were obtained and compared to a control strain and cultures treated with both compounds. In this ciliate, EuCl3 is more toxic than Eu2O3. LC50 values show that this microorganism is more resistant to these Eu(III) compounds than other microorganisms. Oxidative stress originated mainly by Eu2O3 is minimized by overexpression of genes encoding important antioxidant enzymes. The overexpression of metallothionein genes under treatment with Eu(III) compounds supports the possibility that this lanthanide may interact with the -SH groups of the cysteine residues from metallothi-oneins and/or displace essential cations of these proteins during their homeostasis function. Both lipid metabolism (lipid droplets that fuse with europium-containing vacuoles) and au-tophagy are involved in the cellular response to europium stress. Bioaccumulation, together with a possible biomineralization to europium phosphate, seems to be the main mechanism of Eu(III) detoxification in these cells.
Planning Studies of Driver Behavior at Pedestrian Crossings Using Whole-Vehicle Simulators
Authors: Burdzik Rafał , Simiński Dawid , Kruszewski Mikołaj , Niedzicka Anna , Zabieva Aliya Batyrbekovna , Mamala Jarosław , Dębicka Ewa
Published: March 2024

The process involved in preparing driving simulator tests is a labor intensive one, and the nature of this complexity depends on the sophistication of the tests to be carried out, as well as the number of participants. Which has an impact on the duration of the research itself. The very solution of using driving simulators is a research tool that has been in use for many years and with great success. They are used in a very wide range of areas of human functioning. They replicate in a very realistic way the conditions that can occur in the external environment, offer the possibility of repetition of particular conditions and insight into certain behaviors that could be very difficult to initiate in real life. This article also describes the dis- ease of using simulators to conduct research activities, along with the workflow from assumptions to finalizing the research. An algorithm is also presented for the study of individual participants, with examples for separate research scenarios concerning driver behavior in the vicinity of pedestrian crossings.
Integration of Piezoelectric Energy Harvesting Systems in Building Envelope for Structural Health Monitoring with Fiber Optic Sensing Technology
Authors: Pracucci Alessandro , Vandi Laura , Belletti Francesco , Melo Amanda Ramos Aragão , Vlachos Marios , Amditis Angelos , Calcagni Maria Teresa , Esteves David Seixas
Published: March 2024

This paper presents a study about the integration of Piezoelectric Energy Harvesting Systems (PE-EHS) in building envelopes for powering Fiber Bragg Grating (FBG) sensors, enabling efficient and low-consumption monitoring with the objective to leverage Structural Health Monitoring (SHM). The research includes preliminary tests conducted in a real environment to validate the PE-EHS when fully integrated into the façade, capturing mechanical vibrations generated mainly by wind loads. Based on these activities, the final configuration of PE-EHS is defined to provide a complete system for façade monitoring. This integrated system includes the Piezoelectric Generator (PEG), Supercapacitor (SC), Power Conditioner Circuit (PCC), Fibre Optic Sensing (FOS) Interrogator, and the IoT Gateway trans-mitting measurement data within an Internet of Things (IoT) monitoring platform. This configuration is tailored to address the challenges related to the structural integrity of building envelopes. Results demonstrate a potential for a stand-alone solution in the façade sector, but, raising issues for certain limitations, requiring further investigation. In particular, the study emphasizes constraints related to the energy production of PE-EHS for façade integration. It highlights the necessity to carefully consider these limitations within the broader context of their applicability, providing insights for the informed deployment of Piezoelectric Energy Harvesting technology in building envelope monitoring.
TEOS-10 Equations for the Lifted Condensation Level (LCL) and Climatic Feedback of Marine Clouds
Authors: Feistel Rainer , Hellmuth Olaf
Published: March 2024

At an energy flux imbalance of about 1 W m–2, the ocean is storing 90 % of the heat accumulating by global warming. However, neither the causes nor the responsible geophysical processes are sufficiently well understood. More detailed investigations of the different phenomena contributing to the oceanic energy balance are warranted. Here, the role of low-level marine clouds in the air-sea interaction is analysed. TEOS-10, the International Thermodynamic Equation of State of Seawater – 2010, is exploited for a rigorous thermodynamic description of the climatic trend of the Lifted Condensation Level (LCL) of the marine troposphere. Rising Sea-Surface Temperature (SST) at constant Relative Humidity (RH) is elevating marine clouds, cooling the cloud base and reducing the downward thermal radiation. This LCL feedback effect is negative and counteracting ocean warming. At the current global SST of about 292 K, the net radiative heat flux from the ocean surface to the LCL cloud base is estimated to 24 W m–2. Per degree of SST increase, this net flux is expected to be enhanced by almost 0.5 W m–2. The climatic LCL feedback effect is relevant for the ocean’s energy balance and may thermodynamically rigorously be modelled in terms of TEOS-10 equations. LCL height may serve as a remotely measured, sensitive estimate for sea surface relative fugacity, or conventional relative humidity.