bluuebunny/crossref_metadata_2025 huggingface dataset:
Importancia de la cohesión grupal en relación con la satisfacción y frustración respecto a la novedad de los contenidos en Educación Física
Authors: Galán-Arroyo Carmen , García-Guillén Maria José , Castillo-Paredes Antonio , Rojo-Ramos Jorge
Published: February 2025

Dadas las tasas de inactividad y sedentarismo, la Educación Física (EF) podría ser la herramienta idónea para crear estrategias y hábitos que promuevan la práctica de actividad física (AF) desde la base. El nivel de cohesión grupal, así como la satisfacción y la frustración sobre la novedad de contenidos de esta asignatura podrían condicionar su desarrollo. Así, el objetivo del estudio es analizar la importancia de la cohesión grupal en el contexto de la EF y explorar la relación con la satisfacción y frustración de los estudiantes respecto a la novedad de los contenidos. Para ello, se seleccionaron 653 estudiantes de secundaria, 41,7% chicos y 58,3% chicas. Los resultados muestran correlaciones positivas entre la cohesión grupal y la satisfacción de los estudiantes, especialmente en el género masculino, sin embargo, se muestra que, una menor percepción de cohesión grupal puede generar sentimientos de frustración respecto a la novedad de los contenidos. Además, se encuentra un mayor nivel de satisfacción por parte de las chicas que de los chicos en cuanto a los contenidos novedosos. Sería interesante crear líneas de intervención educativa y planificar programas que puedan mejorar el contexto educativo.
Relationship between physical condition and academic performance in rural Romanian schoolchildren
Authors: David Filomena , Salamon Pál , Bodor Zsolt , Miklossy Ildikó , Orban Csongor , Albert Beáta
Published: February 2025

This study explored the relationship between body mass index (BMI) and motor skills among 5th to 8th-grade boys aged 11-14 in a rural public elementary school. Conducted in a demographically diverse school with a consistent curriculum, the research minimized external variables. BMI was determined according to international guidelines, and motor competencies were assessed using standardized tests (50-meter sprint, 1000-meter run, standing long jump, sit-up test, plank test). Cognitive tests included the Stroop Test and Digital Symbol Test. Results revealed a significant negative correlation between higher BMI and motor skills, indicating that higher BMI scores were associated with lower motor test performance. This finding highlights the detrimental impact of higher BMI on physical performance and emphasizes the importance of preventive measures and early interventions to address adolescent obesity. The study underscores the need to understand the link between physical fitness and body composition to develop effective educational and health programs. Further research is necessary to clarify causal relationships and design tailored interventions to improve motor skills and prevent childhood obesity. In addition, future studies should explore gender differences and their potential effects on academic performance and cognitive development to gain a more comprehensive understanding of the factors influencing physical and cognitive outcomes.
Análisis del efecto de la aplicación del estilo actitudinal en la motivación y las actitudes de los estudiantes de secundaria en Educación Física
Authors: Álvarez-Sánchez José Luis , Salicetti-Fonseca Alejandro , Hortigüela-Alcalá David , Gutiérrez-García Carlos , Pérez-Pueyo Ángel
Published: February 2025

La presente investigación mide los efectos del modelo pedagógico emergente Estilo Actitudinal en los niveles de motivación y actitud hacia la Educación Física de estudiantes de Educación Secundaria a lo largo de un curso escolar. La metodología empleada fue de tipo cualitativo, mediante la aplicación de grupos de discusión focal y el uso de un diario digital del profesor encargado de dirigir las clases. Un total de 56 estudiantes participaron en el estudio (25 hombres y 31mujeres, con edades comprendidas entre los 15 y 17 años). Los resultados cualitativos indican que los estudiantes reportaron un aumento en el disfrute y la participación en las clases de Educación Física, así como una mejora en las interacciones sociales y en la sensación de competencia. Estos hallazgos sugieren que el modelo Estilo Actitudinal no solo mejora la motivación y las actitudes, sino que también fomenta un entorno de aprendizaje colaborativo y de apoyo. Las implicaciones del estudio destacan el potencial de este modelo para ser adaptado a diversos niveles educativos y contextos culturales, ampliando así su impacto sobre la motivación y actitud de los estudiantes.
Economic Conditions, Tourism Destination Competitiveness and Tourism Performance: Unravelling the Dynamics in Middle-Income Countries
Authors:   School of Business and Economics United International University, Dhaka 1212, Bangladesh, Hossain Md. Kaium , Hanafiah Mohd Hafiz ,   Faculty of Hotel and Tourism Management Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia, Hamid Abu Bakar Abdul ,   Infrastructure University Kuala Lumpur, Selangor, Malaysia
Published: February 2025

This study examines the role of economic conditions in moderating the relationship between tourism destination competitiveness (TDC), tourism performance (TP), and quality of life (QoL) in middle-income countries (MICs). Using a quantitative approach with data from 67 MICs—including upper-middle-income countries (UMICs) and lower-middle-income countries (LMICs)—the research employs Partial Least Squares-Structural Equation Modelling (PLS-SEM) and Multi-Group Analysis (MGA). Findings reveal that in UMICs, economic conditions significantly moderate the effects of destination management and environmental quality on tourism performance. However, no significant moderation is found for core resources, supporting resources, or tourism prices. In LMICs, economic conditions significantly influence the relationship between tourism performance and quality of life, suggesting that effective tourism management can enhance residents' well-being. The study underscores the importance of tailoring tourism policies to economic conditions, highlighting the need for UMICs to fully address economic leakage to realise tourism benefits. This research contributes to understanding how economic conditions shape tourism dynamics and provides insights for tourism policymaking in MICs.
Influence of Self-control and Religiosity on the Academic Flow of Islamic Education Students at Universitas Muhammadiyah Yogyakarta, Indonesia
Authors: Aqmar Sovia Nabila
Published: February 2025

This study aimed to analyze the level of self-control, religiosity, and academic flow in students as well as the influence of self-control and religiosity on academic flow in students. This study used a descriptive, quantitative approach. The study population comprised 108 students from a private university in Yogyakarta, followed by a sample study of 85 students. Simple random sampling was used. The instruments were a Likert-scale questionnaire and interviews. A double linear regression test was used for the data analysis. The results of the study showed that 1) the self-control rate of students in the average category was 68.2%, 2) the religiosity of the students in the medium category was 78.0%, 3) the academic flow rate for the average student was 77.6%, and 4) the F test or simultaneous self-controlled and religious influence together on academic flows with a significance of 0.05. The r-square value of the influence of self-control and religiosity academic flows was 30.5%, while the other 69,5% were influenced by other variables not mentioned in the independent variable of this study. The combination of self-control and religiosity toward academic flow provides a new perspective that integrates psychological and spiritual dimensions. In the world of education, increased self-control and religiosity give students good self-control, value the learning process, and regard it as worship and moral responsibility, which can support more orderly academic development and student growth in higher academic achievement.
Development and Acceptability of Mead Wine Flavored with Dragon Fruit (Selenicerius undatus)
Authors: Agcaoili Josiefel Zamora
Published: February 2025

This paper discusses the development and acceptability of Mead wine flavored with Dragon Fruit. A Quantitative Descriptive Analysis Survey was utilized among forty (40) panelists who are experts in alcohol while 75 respondents were randomly selected as participants in the sensory analysis using a Hedonic rating scale with a 5-point Likert scale. The results of the study have shown that the product was acceptable considering its color, aroma, taste and even the alcohol content of both treatments. In the findings, the highest responses on color is ruby with 62.5%, responses on aroma are regarded as sweet, tangy and even zesty nuance. The taste reveals that it is fairly acceptable with a 2.30 mean, which accounts for its acidity and good for food pairing. On the overall acceptability level of the three coded samples, wine coded control got the highest description of high acceptable and a mean of 4.38. While in the willingness to purchase the product, commercial product got the highest mean of 4.13, acceptable and wine with code treatment 1 got a high score of 4.03, also acceptable. The results of this study imply that mead with added dragon fruit has the potential to produce mead that is preferred by respondents.
Contribuições do Psicopedagogo para o Processo de Ensinar e Aprender em EAD: Perspectiva em Devir
Authors: Alcântara Patricia , Ribeiro Mayra
Published: February 2025

O presente artigo objetiva refletir sobre as contribuições do psicopedagogo nos processos formativos da Educação a Distância no contexto do Curso de Licenciatura em Educação do Campo, na modalidade EaD da UERN. Alude aos desafios e às potencialidades de pensarfazer Educação a Distância a partir da perspectiva da Educação online, com o foco na atuação do psicopedagogo junto aos discentes dessa modalidade. Como metodologia, nos inspiramos na pesquisa-formação na Cibercultura e nas epistemologias multirreferencial e com os cotidianos. Acionamos dispositivos metodológicos para ir ao encontro formativo dos estudantes no Ambiente Virtual de Aprendizagem (AVA) Moodle, em conversações online e em momentos de sistematização organizacional de espaçotempo de estudos. Como conclusão do vividosentido na pesquisa-formação, construímos a noção subsunçora do ciberpsicopedagogo na EaD, que, para nós, diz respeito à contribuição desse profissional como postura em devir para o processo de aprendizagem dos discentes, em uma perspectiva mais autoral, autônoma e responsável na formação. 
 
Palavras-chave: Educação a distância. Cibercultura. Psicopedagogo. Ensino-aprendizagem.
Savings behavior of college teachers: A comparative study among private and government colleges in Bangladesh
Authors: Lina Rafia Islam , Rahman Md Habibur , Islam Md Shamimul
Published: February 2025

The main objectives of a person’s savings are to improve their standard of life, income, and overall financial well-being. The purpose of the research is to comprehend how public and private college teachers manage their finances. The specific goal of the study is to pinpoint and examine the college teachers' savings behavior, motivations, and important factors determining their savings. A set of structured questionnaires was used to gather primary data from 160 government and private college teachers from the Cumilla district of Bangladesh. The gathered data is analyzed using both descriptive and inferential statistics. Findings reveal that teachers are mainly safe to ensure a better future life. The regression result shows that family size and how often people save are negatively related. On the other hand, age, education level, length of service, monthly family income, how often people save, and income from other sources are positively related to annual savings. The study has identified a sharp difference in the motives of savings between government and private college teachers. The length of service, monthly income, and educational qualifications of the college teachers have positive and significant influences on their savings behavior. Policymakers, researchers, and other relevant private-public groups may find the study useful in understanding teachers' savings habits and in taking necessary action to support both the country's economic growth and teachers' financial well-being.
Intellectual capital and sustainable growth of listed non-financial firms in Nigeria
Authors: Oyeyemi Ogundajo Grace , Ayodele Abiola Oluwatobi , Olawale Osinowo Olalekan , David Olunuga Olusoji , Chukwuekwu Ojianwuna , Abimbola Busari Tajudeen
Published: February 2025

Businesses that prioritize sustainability often gain a competitive edge in the marketplace. However, research suggests that non-financial firms in Nigeria are struggling to incorporate various elements of intellectual capital into their operations, threatening their corporate sustainability. While there is considerable literature on intellectual capital and sustainability in the financial sector, there is limited research on this topic in Nigeria's non-financial firms, which are vital to the economy. This study, therefore, investigates the impact of intellectual capital on the corporate sustainability of non-financial firms listed in Nigeria. The study employed an ex-post facto research design, focusing on 32 companies listed in the industrial and consumer goods sectors on the Nigerian Exchange as of December 31, 2020. Using a purposive sampling technique, a sample of 20 firms was selected for analysis over a 15-year period (2007–2021). The data were sourced from the published annual financial statements of the selected firms, with the reliability of the data ensured by statutory audits and certifications from regulatory agencies. Data analysis was conducted using both descriptive and inferential statistics, with a focus on the System Generalized Method of Moments (SGMM) at a 10% significance level. The findings indicate that intellectual capital significantly influences earnings sustainability (W(6, 287) = 95.26, p < 0.10). The study concludes that intellectual capital plays a crucial role in enhancing the corporate sustainability of non-financial firms in Nigeria. Consequently, it is recommended that these firms integrate intellectual capital into their operations to strengthen their sustainability efforts.
Nepalese banking in the digital era: An evolution of mobile banking adaptation
Authors: Lama Padam Bahadur , Lamichhane Basu Dev , Chalise Sabina
Published: February 2025

The research paper assesses the influence of perceived ease of use, perceived trust, social influence, and facilitating conditions on behavioral intention to adopt mobile banking services. The study fills up the research gap revealed in the literature. Research embraced the positivism philosophy and deductive approach. The cross-sectional primary sources of data employed for the study. A convenience sampling technique was employed in this research. The structured questionnaire of 607 was distributed to respondents in Kathmandu, Nepal, and received only 400 useful questionnaires. Descriptive statistics were utilized to depict the general background information of respondents. Correlation analysis was utilized to assess links between predictors and response variables. Further, linear regression analysis is employed to investigate the effects of predictors on response variables. The findings of the result revealed positive links between perceived ease of use, perceived trust, social influence, facilitating conditions,  and behavioral intention to adopt mobile banking services. It depicted that the factors determining the behavioral intention for the adoption of mobile banking services depend on perceived ease of use, perceived trust, social influence, and facilitating conditions. The findings of this study contribute to existing literature and can be applied to understand the determining factors of the behavioral intention of users of mobile banking services to adopt appropriate policy and for the decision-making process.
The influence of the low birthrate on Taiwan’s preschool enrollment and strategies implemented to cope with this influence
Authors: Hsu Meng-Chin , Chiang Yu-Ming , Shih Yi-Huang , Juan Chen-Ya , Liu Yi-Yi
Published: February 2025

This study explored the influence of the low birthrate in Taiwan on preschool enrollment and the preschools’ strategies for coping with this influence. The researchers developed a questionnaire: Influence of Taiwan’s declining birthrate on preschool enrollment. This questionnaire was administered along with the coping orientation to problems experienced scale to randomly sampled preschool teachers. The findings revealed that (1) the low birthrate has considerably affected Taiwanese preschool enrollment.  Most preschools face insufficient enrollment, enrollment difficulties, increased marketing costs and (2) the influence of the low birthrate. Taiwanese preschools should increase their investment in improving their learning environments and equipment, software and hardware facilities and teaching quality and should establish characteristics specific to the preschool to improve recruitment. The findings of this study indicate that preschools should (1) increase their income and reduce their expenditures.  (2)  Strengthen their integrated marketing and focus on brand and word-of-mouth marketing.  (3) Conduct internal and external evaluations of their service quality.  (4) Consistently improve the professional quality of their teachers and childcare personnel, implement curriculum innovation and (5) improve their competitiveness in the market. This study presents this overview to clarify the necessity of this study and how this study can contribute to the academic understanding of this topic.
Innovative Egyptian style sweet and sour table olives
Authors: Eid Mounir M , Mostfa Dalia M , Ali Safaa E , Elsorady Muhammad E
Published: February 2025

Egypt and the EU are the main producers and consumer countries of table olives in the world. The effect of using sugar (3%) in two different treatments (olives treated with NaOH and natural olives) in brine and packaging solutions on the fermentation process was studied. Physical–chemical parameters, including pH, acidity, NaCl content, reducing sugar, and phenol content, were determined for 12 months of storage time, as well as sensory analysis. Results revealed that pH limits were ≤4.0 for treated olives and ≤4.3 for natural olives after 8 months of storage. Moreover, acidity increased with increasing storage time, irrespective of the treatment used. Regarding salt content, values in all treatments were higher than the established limit of the IOC. In addition, data illustrated that treated olives had a lower content of reducing sugars than those of natural table olives. Results also revealed that the phenol content of treated and natural table olives decreased continuously during the fermentation process. The sensory profile regarding hardness, fibrousness, crunchiness, saltiness, acidity, and bitterness was evaluated after 12 months. All treatments were free from abnormal fermentation and defects. The organoleptic analysis of table olives with added sugars showed a unique profile with an increase in acidity and sweetness.
Intestinal microbiota and gastrointestinal diseases: Irritable Bowel Syndrome
Authors: Esmaeili Fataneh , Shanaki Mehrnoosh
Published: February 2025

Gastrointestinal microbiota, also known as “microflora,” is a collection of microorganisms that inhabit the gastrointestinal tract. Under normal circumstances, the microbiota helps maintain intestinal homeostasis. However, some resident bacteria can transition from symbionts to pathobionts, leading to the development and progression of gastrointestinal diseases such as functional dyspepsia, severe diarrhea, inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS). IBS is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits, including cramping, gas, and constipation. This mini-review will briefly describe microbiota, IBS, the interrelationship between IBS and microbiota, and the therapeutic use of microbiota in treating IBS.
The expression of sirtuins in breast cancer and their prognostic and clinicopathological significance: a systematic review
Authors: Naseri Ehsan , Abdolvahabi Zohreh , Safizadeh Banafsheh , Zarrinnahad Hannaneh , Moradi Yousef , Soheili Marzieh , Baradaran Hamid Reza , Nourbakhsh Mitra
Published: February 2025

Objectives: Sirtuins (SIRTs) are a highly conserved family of enzymes that play an important role in cancer emergence and progression, including breast cancer. In this review, changes in the expression of different SIRTs in breast cancer and their association with metastasis and cancer grade were investigated.
Methods: This study was performed on 44 selected articles on breast cancer, which were extracted from PubMed, Scopus, and Web of Science. Among the selected articles, there were 31 case-control and 13 cohort studies with a total of 7326 and 4760 participants, respectively.
Results: In most studies, SIRT1, SIRT5, and SIRT7 expression levels were higher than the controls, while the expression levels of SIRT4 and SIRT6 were lower. Elevated levels of SIRT1 were associated with an increased risk of distant metastatic relapse (DMR), death, and recurrence, as well as reduced relapse-free survival (RFS). Additionally, there was a significant correlation between increased levels of SIRT1 and metastasis of lymph nodes and other tissues. Reduced levels of SIRT4 were associated with decreased overall survival (OS).
Conclusion: Our findings suggest that elevated levels of SIRT1, SIRT5, and SIRT7 may have potential value for use in the diagnosis of breast cancer. Increased levels of SIRT1 can be used as a prognostic marker.
Efficacy of intravenous immunoglobulin therapy in hospitalised patients with COVID-19: A randomized controlled trial
Authors: Ghezelbash Behrooz , Mafi Alireza , Rostami Mehdi , Tavakol Negah , Salami Raziyeh , Gholinezhad Yasaman , Kasravi Mohammadreza , Rajbzadeh Alireza , Eskandari Nahid
Published: February 2025

Objectives: Acute respiratory distress syndrome (ARDS) is one of the life-threateningcomplications of COVID-19. The occurrence of ARDS is due to overactivation of thehost immune response to the virus. The purpose of this study is to investigate whetheradministration of intravenous immunoglobulins (IVIG) could enhance the outcomes ofseverely ill COVID-19 patients with ARDS.
Methods: In this randomized controlled trial at Milad Hospital of Isfahan, Iran, 88patients were randomly assigned between May and October 2020. The patients had nosignificant differences in age and sex. The patients were divided into two groups: thegroup who received IVIG and routine treatment (n=44, 50%) and the control group whowere just treated with routine treatment (n=44, 50%). The outcomes of patients, includinghospitalization duration, ICU admission period, and total death occurrence, besides clinicaland laboratory parameters, were followed and compared between the two groups.
Results: Primary outcomes of patients, including hospitalization duration (P=0.18),ICU admission period (P=0.35), and mortality (P=0.621), had no significant differencebetween the IVIG group and the control group. At day 3 and day 5 of IVIG administration,clinical and laboratory outcomes were screened. The clinical parameter that improvedwas oxygen saturation compared to the control group (87.56 ± 6.72 vs. 86.72 ± 7.52).In the cardiovascular system, IVIG significantly decreased diastolic blood pressure(P=0.02). In terms of coagulation parameters, IVIG treatment decreased PTT while itincreased D-dimer, but no effect on platelet count and PT was seen. The inflammatoryparameters, including ESR, CRP, and IL6, had no superior changes between the IVIGgroup and the control group.
Conclusion: Our study demonstrated that there were no superior advantages inCOVID-19 patients with ARDS who were treated with IVIG..
Alpha 1-antitrypsin as a potent biomarker for monitoring of disease severity in patients with Covid-19 and its correlation with Liver Enzymes and Lactate Dehydrogenase
Authors: Salehi Mohammad , Sahebghadam Lotfi Abbas
Published: February 2025

Objectives: Alpha 1-antitrypsin (A1AT) is a single-chain glycoprotein containing 394 amino acids. It is primarily synthesized in the liver as an acute phase protein. According to recent studies, the COVID-19 virus can infect host cells by binding to the ACE2 receptor via a membrane protein. On the other hand, A1AT has the potential to inhibit neutrophil elastase and prevent the entry of the virus into host cells. Consequently, A1AT can reduce the severity and duration of COVID-19 disease
Methods: Thirty-one hospitalized COVID-19 patients with a positive PCR test and thirty healthy volunteers with a negative test as the control group were selected. Upon hospitalization, demographic and biochemical tests were conducted for both patients and controls. Serum A1AT levels in both groups were measured using nephelometry as the reference method. Liver enzymes and total protein were also determined using commercially available kits.
Results: Serum A1AT levels in the patients were increased compared to the control group, and this increase was inversely proportional to the duration of hospitalization and the relative improvement for discharge. Additionally, this elevation was correlated with qualitative C-reactive protein (CRP) levels. Serum liver enzymes, ALP, and LDH in patients were significantly higher than in the controls (P<0.05), while serum total protein in patients was significantly lower than in the controls (P<0.05).
Conclusion: These data belong to a homologous group and show a correlation between serum A1AT levels and the duration of hospitalization, as well as with qualitative CRP levels. Furthermore, the increase in A1AT is proportional to the levels of serum AST, ALT, total protein, ALP, and LDH, which may serve as an alarm for potential liver involvement in such a disease. Thus, monitoring the liver condition is warranted.
The Inhibitory Effects of Hesperetin, a Natural Flavonoid, against Substance P-induced Inflammatory Responses in Glioblastoma Cells
Authors: Aliee Ali , Hashemy Seyed Isaac , Ebrahimi Safieh
Published: February 2025

Objectives: As a key inflammatory neuropeptide, substance P (SP) is involved in Glioblastoma multiforme (GBM) carcinogenesis and tumor progression. Thus, the proinflammatory effects of SP must be strictly regulated in GBM patients. The purpose of the study is to examine whether Hesperetin, a natural flavonoid found in citrus fruits with strong anti-inflammatory and anticancer effects, can regulate SP-induced inflammation in GBM primary human cells
Methods: The primary human cells were derived from fresh surgically resected tissue samples of GBM patients and characterized by immunocytochemical analysis of Ki-67. MTT assay was used to evaluate cell proliferation. Apoptosis was detected by an Annexin-V/propidium iodide assay kit using flow cytometry. The levels of the specific inflammatory mediators were measured by western blotting and enzyme-linked immunosorbent assay.
Results: We observed that Hesperetin effectively reduced GBM cell viability in a dose- dependent manner, which was associated with the induction of apoptosis. Obtained findings indicated SP increased the protein expression of phosphorylated-NF-κB, the main regulator of inflammatory processes, and the pro-inflammatory cytokines (IL-1β, TNF-α), while Hesperetin treatment reduced the effects of SP.
Conclusion: Taken together, our findings highlight the role of SP-induced inflammatory responses in GBM pathology and suggest that Hesperetin could be an effective therapeutic strategy in attenuating SP-associated inflammation.
Hemostatic Properties of Green Hydrogel Synthesized from Chitosan/Gelatin Polymers and Hydroalcoholic Extract of Juglans Regia L: An In-Silico and In-Vitro Study
Authors: Sahraian Mahta , Delavarian Fatemeh , Davoudi Maryam , Saberian Mostafa , Afrisham Reza
Published: February 2025

Objectives: Quercetin-3-O-rhamnoside, an effective antioxidant, exists in walnut leavesand is supposed to maintain the structural integrity of the Band 3 protein of red bloodcells (RBCs). In this context, an attempt was made to explore the in-silico and in-vitrohemostatic effects of chitosan/gelatin hydrogels containing hydro-alcoholic extract ofIranian walnut leaves (Juglans regia L.), rich in quercetin-3-O-rhamnoside.
Methods: In-silico molecular docking predicted the potential interaction betweenquercetin-3-O-rhamnoside and Band 3 protein. Hydroalcoholic extraction (1:1 water:70% ethanol) of walnut leaves was performed in a Soxhlet extractor. The hemostaticactivity from various extract concentrations (0%, 2.5%, 5%, 10%, and 20% v/v) wasassayed using the prothrombin time test on citrated blood samples. Gelatin/Chitosanhydrogels (3:1 and 2:1) loaded with the hemostatic concentrations were prepared bythe casting method, and their adhesion ability to RBCs was tested by measuring theconcentration of free hemoglobin in comparison with controls such as sterile gauze andfree-hydrogel positive controls.
Results: Quercetin-3-O-rhamnoside exhibited a high affinity for Band 3 protein,presenting a binding energy of -8.39 kcal/mol compared to the standard ligand 4KUwith -7.11 kcal/mol. The nine amino acids found to be important in this interactioninclude THR728, SER465, VAL729, ARG730, ILE531, LYS851, ILE528, PHE532, andPHE792. All hydrogels incorporating 2.5% v/v of extract could significantly enhanceRBC adhesion controls (p < 0.05).
Conclusion: The hydroalcoholic extract from Juglans regia L. may be of value as anantioxidant and hemostatic agent. Quercetin-3-O-rhamnoside is suggested to be extractedfrom walnut leaves and directly incorporated into the hydrogel, and its hemostatic andantioxidant properties can be investigated at both in vitro and in vivo levels
Annual Output of “Iranian Journal of Public Health” from 2021-2024
Authors: Farhud Dariush D
Published: February 2025

The Article Abstract is not available.
Assessing the Impact of Multidisciplinary Team (MDT) Care on Patients with Liver Cancer/Cirrhosis: A Systematic Review and Meta-Analysis
Authors: Peng Qin , Li Lin , Yang Jing , Tao Kaishan , Zhao Xian , Wang Lin , Jiang Xiaosong
Published: February 2025

Background: Liver cancer and cirrhosis are significant public health challenges with a high global burden. Multidisciplinary Team (MDT) care has gained recognition as a promising approach to improve the management and outcomes of patients with liver cancer and cirrhosis. We aimed to evaluate the effectiveness of MDT care in improving the clinical outcomes, including survival rates, quality of life, and disease progression, in patients with liver cancer and cirrhosis.
Methods: The search was performed using the keywords of liver cancer and MDT and their combinations in international databases with a time limit for publishing articles from 2010 and 2023. The data were evaluated using a technique of meta-analysis as well as a model called random effects. The I2 test was used to examine the degree of heterogeneity between the studies. STATA was used to analyze the data.
Results: The analysis of 13 different papers with a total sample size of 8641 individuals revealed that the average scores of the MDT and liver cancer were identical to (0.64), with a confidence interval ranging from (95% 48.5-81.7).
Conclusion: MDT is effective in the length of treatment and reduction of risk and mortality rates. The negative prognostic factors of not following the MDT decision were not observed.
The Updated Trend of Association between Dental Caries and Stunting in All Age Groups: A Systematic Review
Authors: Setijanto Darmawan , Hemadi Abdullah Sherf , Dewanto Iwan , Adiatman Melissa , Wulan Kartika Andari , Ningrum Valendriyani , Widyarman Armelia Sari , Jovina Tince Arniati , Arfani Naneu Retna , Dharmawan Indra Rachmad , Nuraini Sri , Mahrunisa Ammara Nabiila , Hidayat Marvin
Published: February 2025

Background: Stunting has a negative impact on the growth and development of children, which include their susceptibility to dental caries. Caries in primary teeth have been consistently related to malnutrition. Having a history of severe caries was connected with slower childhood growth. We aimed to explain the updated trend of association between stunting and dental caries among all age groups.
Methods: A review was done using PRISMA. PubMed and Science Direct was used as database from Jan 2022 to Jan 2023. Studies obtained using specific keywords was 1.748 then filtered. All of the studies that were obtained using specific keywords about stunting and DMFT and or PUFA index. There is no limited year in this systematic search. Endnote software was used to help with the inclusion process; data was extracted into a table that had been prepared.
Results: There were 10 included studies in this systematic review. Eight studies that reported higher dental caries in stunting children than the normal children. Two studies showed a connection between developing stunting malnutrition and severe dental caries. Early childhood caries may increase vulnerability to dental caries by causing odontogenesis to fail, delayed tooth eruption and changes in the salivary glands. Children's ability to eat and sleep may be negatively impacted by untreated caries pain. It might result in decreased nutrient intake and poor appetite, while sleep disturbances might prevent growth hormones from being secreted.
Conclusion: There was a correlation between dental caries and growth stunting because of a decrease in the composition of saliva and defects in tooth formation in children suffered stunting. Thus, there were oral functional limitations and a decrease in food intake since severe dental caries.
The Effect of Intermittent Fasting Combined with Ad Libitum Days on Adults’ Elevated Blood Pressure: A Systematic Review of Human Studies
Authors: Baharuddin Dharina , Said Mas Ayu , Majid Hazreen Abdul
Published: February 2025

Background: Diets utilizing intermittent fasting as an alternative method to promote weight loss have grown in popularity. However, the efficacy of intermittent among elevated blood pressure remains unclear. This review systematically analyses studies investigating the effects of intermittent variations among elevated blood pressure on changes in systolic blood pressure and diastolic blood pressure. Changes in body weight, body mass index, waist circumference, and energy intake were assessed as a secondary objective.
Methods: The American Search Elite, CINAHL, Cochrane, MEDLINE, ProQuest, PubMed, Scopus, and grey literature databases were searched for articles investigating intermittent fasting with ad libitum among adults with elevated blood pressure from Jan 2010 to Jun 2022.
Results: Twelve studies met the eligibility criteria. Systolic and diastolic blood pressure generally decreased, between -2.0 to -0.04 mmHg and -3 to -0.01 mmHg, respectively. The body weight and body mass index reduced significantly (-2.85 to -0.09 kg and -1.05 to -0.03 kg/m2, respectively). The review found a waist circumference reduction of -0.67 to -0.21 cm and an energy intake reduction of -263.89 to -2.58 kcal.
Conclusion: Intermittent fasting reduces systolic and diastolic blood pressure in 2-24 wk while decreasing body weight, body mass index, and energy intake. However, needs 48 wk to reduce waist circumference. This implies that it is critical to perform intermittent fasting on elevated blood pressure before the development of high blood pressure as part of a program to prevent hypertension in adults.
Clinical Application Effect of Postoperative Nursing Intervention on Patients Undergoing Transurethral Prostatectomy: A Systematic Review and Meta-Analysis
Authors: Guo Baolian
Published: February 2025

Background: To study the clinical effect of postoperative nursing on patients undergoing transurethral resection of the prostate (TURP).
Methods: The relevant researches about nursing intervention effect evaluation after TURP during January 2000 to May 2024 were selected from databases. These were sorted into an intervention group (Int group) and a control group (Ctrl group) with different nursing methods. Theemotional status, length of hospital stays (LOHS), nursing satisfaction, the incidence, volume, and frequency of urinary incontinence (UI), and the incidences of urinary hemorrhage (UH), bladder spasm (BS), and catheter occlusion (CO) were compared after intervention.
Results: Eleven articles and 1,020 cases were included. The LOHS in the Int group was much shorter (mean difference (MD)=-2.91, 95% confidence interval (CI): -4.47~-1.35, Z=3.66, P=0.0002). The nursing satisfaction was significantly improved (odds ratio (OR)=5.70, 95% CI: 3.65-8.90, Z=7.64, P<0.00001). For complications, incidence of UI (OR=0.41, 95% CI: 0.26-0.66, Z=3.72, P=0.0002), the volume of UI (MD=-66.17, 95% CI: -124.74~-11.60, Z=2.36, P=0.02), and the frequency of UI (MD=-1.18, 95% CI: -1.69~-0.67, Z=4.55, P<0.00001) greatly reduced. The incidences of UH (OR=0.43, 95% CI: 0.21-0.87, Z=2.35, P=0.02), BS (OR=0.24, 95% CI: 0.14-0.42, Z=4.97, P<0.00001), and CO (OR=0.20, 95% CI: 0.11-0.36, Z=5.21, P<0.00001) were also highly reduced.
Conclusion: Postoperative nursing intervention could effectively shorten LOHS after TURP in patients with benign prostatic hyperplasia (BPH), improving the nursing satisfaction and reducing the incidence of postoperative complications.
Association between P53 Gene Mutations and Colorectal Cancer in the Iranian Population: A Systematic Review
Authors: Kavishahi Nima Nikbin , Khojini Javad Yaghmoorian , Khamespanah Duruh Mehrazin , Babaei Benjamin , Sheikhha Mohammad Hasan
Published: February 2025

Background: Colorectal cancer (CRC) is the fourth most common cancer and one of the most significant cancers affecting the Iranian population. This systematic review aimed to investigate the association between mutations in the P53 gene and CRC.
Methods: We conducted a search of six databases, including; Scopus, PubMed, Web of Science, Cochrane Library, SID, and Magiran up to Aug 10, 2024. Concepts in the search strategy were Iran, P53, and "Colorectal cancer". Original articles written in English or Persian that investigated the association between P53 gene mutations and CRC in the Iranian population were included.
Results: Out of 313 articles, 17 articles were included in the study. Six case-control studies investigated the association between the codon 72 polymorphism of the P53 gene and colorectal cancer. Three studies found a significant difference in genotype frequencies of this polymorphism between CRC patients and healthy individuals. Exon 6 was shown to be one of the most common mutated exons in colorectal cancer. Mutations in exon 7 were associated with poor prognosis. The most common type of mutation was G to A mutation from exons 5 to 8 CpG sites.
Conclusion: The present study suggests a potential association between the presence of the Arg allele at codon 72 within the P53 gene and a heightened susceptibility for developing and metastasizing CRC within the Iranian population. Furthermore, exons 5 to 8 of the P53 gene suggests that mutations localized at these sites may portend a poor prognosis.
Effects of Gestational Diabetes Mellitus on Fetal Liver Length: A Systematic Review and Meta-Analysis
Authors: Khales Sahar Ardalan , Rajabi Abdolhalim , Golalipour Masoud , Roshandel Gholamreza , Golalipour Mohammad Jafar
Published: February 2025

Background: Gestational diabetes mellitus (GDM) is a serious pregnancy complication that can affect various organs and organ systems of the mother and fetus. In diabetic mothers, increased blood glucose delivery to the fetus leads to fetal hyperglycemia and hyperinsulinemia, which promotes the growth of insulin-dependent organs such as the liver. Therefore, this systematic review and meta-analysis was conducted to more precisely estimate the association between GDM and fetal liver length (FLL).
Methods: Six electronic databases (PubMed, Scopus, Web of Science, ProQuest, Cochrane, and Wiley) were searched up to Aug 2023. Two reviewers independently extracted data and assessed the risk of bias using the Newcastle–Ottawa Scale. The pooled weighted and standardized mean differences in FLL were calculated using random-effects models. Heterogeneity, subgroup analysis, and publication bias were also assessed using funnel plots. All statistical analyses were performed using Stata Version 16.0.
Results: Twelve articles were included in the final meta-analysis. GDM was associated with increased FLL, as assessed by ultrasound, in both the second (SMD=1.56; 95% CI: 1.04, 2.08; P<0.001) and third (SMD=0.84; 95% CI: 0.07, 1.61; P<0.001) trimesters of pregnancy. The pooled mean difference in FLL between the GDM and non-GDM groups was 4.85 mm (WMD=4.85; 95% CI: 3.26, 6.45), indicating larger liver size in fetuses from mothers with GDM.
Conclusion: GDM is a significant risk factor for increased FLL, as assessed by ultrasound, which may reflect fetal overgrowth and metabolic dysfunction.
Iran’s Leap into the Future; an Exploration of Tissue Engineering Companies: Review Article
Authors: Fereydouni Narges , Ebrahim Astaneh Mohammad , Seifalah-Zade Morteza , Hashemzadeh Alireza
Published: February 2025

Background: This review represents the first comprehensive compilation of data on Iranian commercial, service, and research entities in the field of tissue engineering up to 2024.
Methods: Through an extensive search of official websites, 56 companies were identified: 29 commercial enterprises, 17 service providers, and 10 research institutions. The majority (64%) of these companies are headquartered in Tehran, with many established post-2004.
Results: Biomaterials account for half of the product portfolio, with 38% of ongoing research focused on this area. Although cell-based products currently make up only 12% of offerings, they are the subject of 38% of current research, indicating significant potential for future growth.
Conclusion: This study provides a detailed overview of the development and future prospects of Iran's tissue engineering sector. The key conclusion emphasizes the need for an expanded focus on cell-based therapies and the establishment of stronger regulatory frameworks to facilitate the commercialization of innovative products. The review identifies key research gaps and proposes directions for future study, utilizing a descriptive methodology with in-depth data analysis and theoretical discussion.
A Scientometric Perspective on Stigma Research in Medicine: A Bibliometric Review
Authors: Akbari Hossein , Mohammadi Mahla , Hosseini Abolfazl
Published: February 2025

Background: Stigma is a critical social determinant of health, influencing individuals' access to resources, quality of life, and overall well-being. Despite its significant implications, bibliometric studies on stigma in the medical field remain sparse. We provide a comprehensive scientometric analysis of stigma research in medicine over the past 30 years, highlighting trends, key focus areas, and evolving challenges.
Methods: A bibliometric analysis was conducted using VOSviewer software, utilizing data from the Scopus database. The search included articles with the keyword "stigma*" in the title, published between 1992 and 2022, within the fields of Medicine, Nursing, and Professional Health. The initial search yielded 20,284 articles, narrowed down to 7,854 relevant publications for detailed analysis. Key metrics analyzed included co-authorship, co-occurrence of keywords, and co-citation patterns.
Results: The analysis revealed a significant increase in stigma-related publications in the medical field, particularly since 2010, with a peak in 2022, largely driven by the COVID-19 pandemic. The research identified nine major keyword clusters, 40 associated diseases, and 36 target groups. Persistent diseases like HIV, mental illness, addiction, and cancer continue to be strongly associated with stigma.
Conclusion: The findings underscore the evolving nature of stigma research in medicine, with an increasing focus on intersecting stigmas and their persistent impact on public health. Future research should aim to develop comprehensive models and strategies to manage and reduce stigma, particularly for diseases with enduring stigmatic associations. Collaborative efforts among policymakers, healthcare providers, and society are crucial to address the social and economic consequences of stigma and improve health outcomes.
Exploring the Association between Childhood Asthma and Abnormal Spermatozoa: An Analysis Using Mendelian Randomization
Authors: Zhang Qian , Ge Yao , Chen Yuan , Zhang Yun , Xie Xiaoyan , Yu Jian , Bao Yunlei , Jiang Feng , Wu Chuyan
Published: February 2025

Background: Childhood asthma ranks among the prevailing chronic respiratory conditions affecting a significant number of individuals. The long-term hypoxic state and chronic inflammatory state caused by asthma could be linked with spermatozoa apoptosis. However, the correlation between childhood asthma and abnormal spermatozoa is currently unknown.
Methods: In our study, the method of two-sample Mendelian randomization (2SMR) was used by searching an appropriate European population genome-wide association studies (GWAS) database of childhood asthma and abnormal spermatozoa from the Ieu Open GWAS Project database. Sixteen related single-nucleotide polymorphisms (SNPs) were screened as instrumental variables (IV). Subsequently, we employ various statistical methods including inverse variance weighting (IVW), weighted median method (WME), MR-Egger regression, Simple mode, and Weighted mode to investigate the causal link between childhood asthma and the development of abnormal spermatozoa.
Results: Based on IVW results, childhood asthma is not an independent risk factor for abnormal sperm formation (P=0.14). Other statistical models such as WME, MR-Egger regression, Simple mode, and weighted mode also showed the same results. Leave-one-out sensitivity analysis and heterogeneity test were conducted and no horizontal pleiotropy was found.
Conclusion: There was no causal relationship between childhood asthma and abnormal spermatozoa formation at the genetic level.
Health Effects of Plant-Based Diets in University Life: A Comprehensive Study on the Constipation, Sleep and Obesity
Authors: Toğuç Hakan
Published: February 2025

Background: Plant-based diets have gained popularity due to their nutrient density and potential to reduce chronic disease risk. The aim of the study was to examine the relationship between diet quality and plant-based diets consumed with constipation, sleep duration and obesity in university students.
Methods: In this study conducted between September and October 2024, 676 students were recruited as participants and data on socio-demographic information, daily sleep duration, presence of constipation, 24-hour food consumption record and food consumption frequency were collected. Diet Quality Index (DQI) and Plant-Based Diet Index (PBDI) were calculated from food consumption record and frequency data.
Results: Constipation was present in 14.5% of the participants and the BMI of the participants was 21.84±3.47 kg/m2. There was a significant relationship between age and constipation (P=0.013) and a weak negative relationship between age and sleep duration and PBDI (r=-0.103, P=0.007; r=-0.077, P=0.045, respectively); A weak negative correlation was found between BMI and PBDI and DQI (r=-0.092, P=0.016; r=0.173, P=0.000, respectively); a significant correlation was found between the presence of constipation and gender and income level (P=0.047; P=0.013, respectively).
Conclusion: PBDI and DQI were associated with lower BMI and emphasised the potential of alternative nutritional models in the fight against obesity. The lack of an association between PBDI, DQI and sleep duration and constipation suggests that further research is needed. This study emphasises the importance of healthy eating and lifestyle interventions, but its design limits causal conclusions and requires further research.