bluuebunny/crossref_metadata_2025 huggingface dataset:
Walka ze stereotypem roli kobiety w kinie współczesnym
Authors: Pękala Iga
Published: February 2023

The aim of the article is to review contemporary films portraying women and to consider what problems female characters face and how they are presented. A significant part of the analysis is focused on portrayals of the struggle against the stereotypes to which the protagonists are subject — and assessing how much film has changed in that regard over the years, both diegetically and extra-diegetically. The article also looks into the form of selected (color) films, the images of marriage and motherhood, as well as the search for clues in youth cinema.
PRACTICE OF KEJAWEN RITUALS THROUGH NGEBLENG FASTING
Authors: Solikhah Amirotun , Saputro Dedy Riyadin
Published: February 2023

Using a phenomenological approach, this study aims to reveal the psychological and social impact on three Ngebleng fasting performers in Kutasari village, Cipari district, and Cilacap district. Documentation and in-depth interviews are the main instruments for extracting as much information as possible and then interpreting it based on the phenomena obtained. The results showed that the psychological impact felt by fasting performers included inner peace, less emotional stress, and healthier physical conditions. Meanwhile, the social effects felt by the ritual actors varied. One perpetrator admitted that after undergoing Ngebleng fasting, he felt the smoothness of rizki and the establishment of good social relations; his fortune was smoother and social relations were not disturbed. Still, two people admitted that when fasting, they became less enthusiastic about interacting with the surrounding community because, apart from feeling weak physically, there were also considerations of maintaining so that the fast does not fail.
HALAL PRODUCTS AND FORMAL PIETY MUSLIM MIDDLE-CLASS LIFE IN THE ANALYSIS OF RELIGIOUS RECEPTION THEORY
Authors: Malik Abdul , Irwan Muh. , Wathani Syamsul
Published: February 2023

The Muslim middle class is a religious group that lives in commodified Islam and is self-commodified with Islam for the benefit of life. Their presence represents two entities, the middle class is attached to material and Muslims are attached to religiosity. These two entities emphasize their existence as new religious communities. This article is an exploratory-verificative research from the results of field research on the Muslim middle class, especially in the study of religious behavior (religious performance). This article focuses on analyzing research gaps, data, theory and theorizing of research results into the scientific development of the sociology of religion. The analytical framework used is the analysis of religion as a tradition and doctrinal reception. With this analytical framework, this article finds several conclusions: The Muslim middle class has a strong dependence on halal products. There are two models of halal in products and social cognition of the Muslim middle class, namely: Islamic products and Islamicized products. Halal status is a driving factor that directs the consumption and consumption of halal products for the middle class, providing assurance of religious morals and an Islamic life. The Muslim middle class also expresses popular culture and formal/symbolic piety in public spaces. Formal piety includes: Islamic pants, beards, syar'i hijab, syar'i robes, veils, syar'i fashion, syar'i cosmetics and other economic artifacts. By characterizing the consumption of halal products and formal piety, the religious behavior of the Muslim middle class is in the low tradition plains. Religious traditions themselves are formed from clashes and greetings from the reality or habitus around them. In piety mapping, the Muslim middle class is in the Islamic category in the form of active piety.”
Importance of participatory narrative inquiry in sensitive research
Authors: Myumbo Ludovick Jacob
Published: February 2023

This paper engages and persuades social researchers to use Participatory Narrative Inquiry (PNI) in their sensitive social research. PNI is a pertinent approach which situates effective communication at the heart of social inquiry – it includes a form of personal interaction based on language, thought, and action which produced an appropriate climate that allows people to clarify their situation and generate personal solutions. Yet, PNI is rarely used in sensitive research. This study provides a window into its use in sensitive research from a perspective of a social researcher who has used it in exploring lived experience of young rural women who sell sex for livelihood in the suburbs of Mwanza town, in Tanzania. PNI afforded a space for a group of six young rural women who are in sex industry to tell stories so as to make sense of their complex situations and redefine themselves. PNI significantly helped the participants to speak about things that they would never have had a chance to speak about, reflect upon issues that would belong to the realm of taboo, and talk about subjects that they would not have been willing or able to speak about directly without the process of narrative inquiry.
Exercise-brain interaction of neuroplasticity: empirical evidence in the rodent adaptation
Authors: Lee Minchul
Published: February 2023

[Purpose] Exercise is gradually being recognized as an essential component of brain plasticity at the molecular, functional, and structural changes levels. What are the causes of the observed exercise reimbursements in neuroscience? Several types of exercises have been studied in various doses in neurological, physiological, psychological, and biochemical experiments. More clarity is required to reveal exercise-brain interactions such as optimal exercise condition variables and neuroplasticity.[Methods] This review briefly highlights the empirical evidence of the positive effects neuroprotective activity on neuroscientific advancement.[Results] The key areas are as follows: (a) stress exercise model using rodents, (b) hippocampal activation and plasticity with exercise, (c) glycogen metabolism in the brain, and (d) adaptation as a high-intensity interval training model in animals involved in exercise-induced brain plasticity.[Conclusion] Overall, exercise-induced molecular, functional, and structural changes in the neuronal system may affect rodents’ performance. This study emphasizes the significance of understanding exercise neuroscience and makes recommendations for future research.
ANALYSIS OF DETERMINANTS OF CORPORATE CASH HOLDING OF LISTED MANUFACTURING COMPANIES ON THE MACEDONIAN STOCK EXCHANGE
Authors:   Faculty of Economics - Skopje, Naumoski Aleksandar
Published: February 2023

In this study, we identify the determinants of cash holding in Macedonian manufacturing companies. The analysis was conducted using accounting data from publicly available financial statements of the sample of Macedonian industrial companies for the 2005 to 2019 period. The research was conducted through the prism of the postulates of the three main theories in corporate finance, i.e., the trade-off theory, pecking order theory,and thefree cash flow theory. To that end, we applied a panel regression analysis, while from the obtained results we assess which theoretical model best explains the cash management in Macedonian companies. We found that the cash to total assets ratio averaged 3.1%. The cash holding decreases with the decrease of the net working capital, financial leverage,cash flow variability, andcash conversion cycle. Cash holding increases with the increase of the company size, cash flow, debt maturity, and capital investments. We concluded that most of the results are in line with the pecking order theory, which indicates that Macedonian companies do not have predefined cash balances, and the cash holdings are abuffer between retained earnings and investments. The level of cash holding is not planned and is not optimized, but is determined during the work processes and depends on other business decisions.
STUDI KOMPARATIF HUKUM KELUARGA DI INDONESIA DAN BRITANIA RAYA (INGGRIS DAN WALES)
Authors: Astuti Fakhriyah Tri , Ndini Cahya Wulan , Riyanti Erni Dewi
Published: February 2023

Tulisan ini membahas mengenai peraturan tentang hukum keluarga di Indonesia dan Britania Raya khususnya di Inggris and Wales. Penelitian ini menggunakan metode komparatif yang menemukan bahwa perbedaan yang terdapat antara pengaturan hukum Keluarga di Indonesia dan Britania Raya dikarenakan beberapa factor yang berbeda seperti, sistem politik, sistem pemerintahan, agama dan keadaan social dan budaya masyarakat. Penelitian ini akan memberikan data dan informasi secara umum mengenai pokok-pokok perbedaan hukum keluarga antara Indonesia dan Britania Raya.
Towards a Simulation Model Complexity Measure
Authors: Thompson J. Scott , Hodson Douglas D. , Grimaila Michael R. , Hanlon Nicholas , Dill Richard
Published: February 2023

Is it possible to develop a meaningful measure for the complexity of a simulation model? Algorithmic information theory provides concepts that have been applied in other areas of research for the practical measurement of object complexity. This article offers an overview of complexity from a variety of perspectives and provides a body of knowledge with respect to the complexity of simulation models. Key terms of model detail, resolution, and scope are defined. An important concept from algorithmic information theory, Kolmogorov complexity, and an application of this concept, normalized compression distance, are used to indicate the possibility of measuring changes in model detail. Additional research in this area can advance the modeling and simulation body of knowledge toward the practical application of measuring simulation model complexity. Examples show that KC and NCD measurements of simulation models can detect changes in scope and detail.
Approach to Applying Sufficiency Economy Philosophy in Community Enterprise Management towards Sustainability
Authors: Mettathamrong Jakret , Upping Phetphrairin , Deeudom Somchad
Published: February 2023

Sustainability is essential for every business and organization, but how can it be achieved? This work is a study of sustainability based on the sufficiency economy philosophy, a valuable concept introduced by the Thai people. We apply it to the notion of sustainability in 400 agricultural community enterprise owners in Thailand, who participated in the study. An oblique rotation component analysis was performed, finding that the variables on the same side are related, and a confirmative component analysis with structural equation models was conducted. The results showed that the approach to applying the sufficiency economy philosophy among community enterprises consists of 11 components, as follows: 1) financial control, 2) planning, 3) member management, 4) morals, 5) prevention plan, 6) moderation, 7) knowledge and expertise, 8) market development, 9) care, 10) quality control and 11) value of investment. The confirmative component analysis with structural equation modeling was consistent with the empirical data. Agricultural community enterprises and entrepreneurs focus on the moral component, conduct business with honesty and avoid causing problems for others, value justice without taking advantage with diligence and adhere to moral principles in life, because all of the above will lead to sustainability in the future.
Adaptive and Learning Methods for Drone Motor Control
Authors: Barnett Brady , Sands Timothy
Published: February 2023

This manuscript explores unmanned aerial vehicle DC motor control performance efficacy of deterministic artificial intelligence in comparison to model-following adaptation, particularly a direct self-tuner with filtering. The deterministic artificial intelligence model made use of self-awareness statements to overcome error in response to permutations of the multi-duty cycle square wave that served as the system input. It can be seen that (despite equivalently powerful estimation techniques) deterministic artificial intelligence provided far superior results: a reduction in peak initial transient error of 55%, and a mean error reduction over 81% with over 65% reduction in error standard deviation compared to a state-of-the-art nonlinear adaptive control method. Deterministic artificial intelligence also was able to very closely track at the switching of the input control, while the benchmark nonlinear adaptive control failed to respond as quickly at these points.
Carbon Emissions in Transportation: A Synthesis Framework
Authors: Ferrer Ana Luiza Carvalho , Thomé Antonio Márcio Tavares
Published: February 2023

With a worldwide growing concern for greenhouse gas (GHG) emissions and their impact on human health and the environment, transportation has become a central theme in mitigation, responsible for 14% of human GHG emissions. To build endurance to climate change, transportation services must adapt to the current scenario and act quickly to avert future changes. Deeply rooted changes in socio-technical systems will be necessary to achieve significant CO2 reduction and secure the well-being of future generations. This study's objective is to comprehensively review the current state of carbon mitigation in the transportation sector. This is done through a systematic literature review engrained in the socio-technical transition theory and the structural theory of contingency. Twenty-six review papers covering 2,983 original articles are selected for full-text examination concerning carbon emissions in transportation. Enablers, barriers, benefits, disadvantages and metrics in carbon emissions reduction are identified, and a comprehensive framework is built. Results provide a view of the current sustainability scenario in transportation and allow a better understanding of the factors influencing carbon emission initiatives in transportation and its outcomes.
An Unusual Case of Nickel Induced Gingival Enlargement and Literature Review: Rare or Ignored?
Authors: Fernandes Gabriela , Nagar Saurabh R. , Pandey Nishant , Rajpari Kamil
Published: February 2023

Background: Gingival enlargement is defined as an abnormal overgrowth of gingival tissues. A case of a 34–year–old female presenting with maxillary chronic inflammatory gingival enlargement associated with a nickel wire allergy is reported here. Replacement of the wire, good oral hygiene therapy and surgical therapy was carried out to provide a good aesthetic outcome. Histopathological evaluation was done of the excised specimen. There is only one similar case reported in literature to the best of our knowledge and ours is the second case. Result: A Histopathological diagnosis of inflammatory fibrous hyperplasia was established. No recurrence was reported at the end of 1 year. Conclusion: The patient should be made aware of the allergy at the initial visit and oral hygiene instructions should be reinforced at every visit. The significance of patient compliance during and following therapy as an important factor in the success of treatment.
Improving Early Childhood Caries for American Indian 3- to 5-Year-Old Children Through Interprofessional Outreach: 2018–2022
Authors: Larsson Laura S. , Hodgson Christine
Published: February 2023

We sought to determine the effectiveness of an interprofessional health team in improving access to oral health care among American Indian children enrolled in Head Start. Our team provided preventive treatments and case management during 11 visits from 2018 to 2022. Case management reduced the time between referral and dental treatment from a median of 166 days to 58.3 days over four years. An interprofessional team is an effective way to improve access to oral health care among rural American Indian Head Start children. (Am J Public Health. 2023;113(4):368–371. https://doi.org/10.2105/AJPH.2022.307205 )
Quadriceps Strain and TKA: Contribution of the Tourniquet and Intramedullary Rod to Postoperative Thigh Pain
Authors: Stocks Gregory W. , Odoemene Melissa , Gex Julia , Vidal Emily A. , Sawyer Kathryn , Jones Stephen L. , Thompson Brandon , Laughlin Mitzi S.
Published: February 2023

Background:

Thigh pain is relatively common after total knee arthroplasty (TKA) and has been attributed to compression of the thigh muscles by the tourniquet used during surgery. Thigh pain that occurs after a TKA that was performed without a tourniquet may be due to a strain of the quadriceps muscle or insertion of the intramedullary (IM) rod. The purpose of the present study was to determine the cause of thigh pain after TKA in a randomized controlled trial evaluating tourniquet use, IM rod use, and quadriceps strain.

Methods:

This prospective randomized controlled trial enrolled 97 subjects undergoing primary knee arthroplasty into 4 groups according to tourniquet use (yes or no) and IM rod use (yes or no). Quadriceps strain was evaluated with magnetic resonance imaging (MRI) on postoperative day 1 (POD 1). Data collected preoperatively, intraoperatively, and postoperatively until the 6-week clinical visit included pain levels for the knee and thigh (recorded separately) and knee range of motion.

Results:

Regardless of tourniquet or IM rod use, 73 (75%) of the 97 patients reported thigh pain on POD 1. Thigh pain at 2 weeks postoperatively was indicative of a quadriceps strain. Use of a tourniquet and patient-reported thigh pain at 2 weeks increased the odds of a quadriceps strain, whereas IM rod use did not significantly contribute to thigh pain.

Conclusions:

The etiology of thigh pain after TKA may be multifactorial; however, an iatrogenic quadriceps strain is one source of thigh pain after TKA, especially if the pain persists 2 weeks after surgery.

Level of Evidence:

Prognostic Level I. See Instructions for Authors for a complete description of levels of evidence.
Derivation of axioloids, an in vitro model of somitogenesis and axial development from human pluripotent stem cells
Authors: Yamanaka Yoshihiro , Hamidi Sofiane , Ericsson Rolf , Munira Sirajam , Alev Cantas
Published: February 2023

Here we describe a step-by-step protocol for the derivation of axioloids, a pluripotent stem cell (PSC)-based 3D in vitro model of human segmentation and somitogenesis. Mesoderm-based axioloids capture reproducibly core features of the segmentation process in vitro including axial elongation, sequential formation of properly patterned epithelial somites and coordinated oscillatory activity of the segmentation clock. Axioloids recapitulate furthermore key morphogenetic and molecular features of post-gastrulation human embryos, including temporally coordinated emergence and spatial organization of somitogenesis-associated mesodermal cell populations, presence of opposing FGF/WNT and RA signaling gradients and spatiotemporally controlled expression of HOX genes. In addition to increasing our still limited understanding of human axial development, axioloids can be used to model and study congenital diseases of the human spine, when utilizing patient-like iPSCs with defined pathogenic mutations in genes such as HES7 or MESP2.
Detection and Prevention of Black Hole Attack in MANET using Node Credibility and Andrews Plot
Authors: Kumari Ankita , Dutta Sandip , Chakraborty Soubhik
Published: February 2023

MANET, a wireless, infrastructure-less, ad-hoc network, uses a dynamic topology rendering for the establishment of connections much easier in any given conditions. The black hole attack is a malicious activity that is performed in MANET which causes depletion of the network. It poses a threat to MANET by incorporating malicious nodes into the network which gives fake routing information to the source node. As the black hole attack acquires the data from the source node, it drops the data packet from the network resulting in the depletion of the network. In this paper, to tackle the black hole attack, we have proposed a node credibility-based approach focusing on Andrews plot to project the node credibility after a few transactions which infer that a high node with high node credibility is the more trusted node in the network. We have used Network Simulator software for the creation of MANET scenarios.
An integrated, non-destructive method for evaluating core quality from R/V Legend’s giant piston coring system
Authors: Yu Pai-Sen , Chen Ting-Ting
Published: February 2023

The quality of marine sediment cores is significant for investigations on marine geohazards, paleoceanography, paleoclimatology, and marine environmental changes. The identification of genuine or artificial sedimentary structures is essential to the development of long piston coring procedures. In this study, we highlight an overlooked primary process of a standard procedure and its effect on the deformation of a sedimentary sequence. The LGD-T32/LGD-T43 cruises of the R/V Legend were designed to test the capability of 8-m-long piston coring offshore southwestern Taiwan. To examine how giant piston coring procedures have shaped the retrieval of sedimentary sequences and affected core quality, we apply well-developed, non-destructive analyses, including physical property measurements, visible color reflectance and the curvature index, to recovered sediments. The continuous sequences of four giant sediment cores at the revisited site are therefore used to provide the basis for comparison with non-destructive results. Rather than dewatering or lithifying the units themselves, we suggest that during the coring procedure, an abnormal pulling force could destroy the balance among the sediments and thus cause the observed deformations of sedimentary features with different magnitudes. We demonstrate that an integration of the curvature index and color reflectance is a better way to evaluate the transformation and distorted sedimentary sequences. Furthermore, using a Taiwan Ocean Research Institute (TORI)-revised piston could potentially produce an abnormal pulling force inside a tube and causing oversampling and distorted sedimentary features, as evidenced by integrated results.
Thermal vibration analysis of scramjet engine structure based on the coupling combustion-thermal-structure approach
Authors: niu yaobin , wang zhongwei
Published: February 2023

A combustion-thermal-structure coupling approach for thermal vibration analysis of scramjet structure is proposed, and it can consider the influences of flight trajectory such as flight altitude, flight Mach number and combustion equivalence ratio on engine vibration characteristics. In this approach, the internal flow field parameters such as pressure and temperature of scramjet engine are determined by means of the quasi one-dimensional model, the combustion heat flow parameters of engine wall are determined by the reference enthalpy method, and the transient structure heat transfer and thermal structure analysis are determined by the finite element method. Based on this approach, the thermal vibration frequency of the scramjet engine and its variation with time are studied. Under the condition of the hypersonic flight, the structural frequency of the scramjet engine decreases gradually with time, and there are great differences in the reduction amplitude at each frequency due to the uneven distribution of structural temperature. In the inlet section with relatively lower temperature, the declining amplitude ratio of inlet breathing and bending modes is the smallest, and the declining in the first 200s is 11.28% and 14.16% respectively. The structure temperature of combustion chamber and nozzle is relatively high, and the corresponding third-order, fourth-order and fifth-order frequencies decrease more, which are 35.81%, 34.32% and 32.36% respectively. The variation of the free vibration frequency of the scramjet engine with flight trajectory such as flight Mach number and flight altitude is studied. With the increase of Mach number, the engine structure temperature increases faster, and each order frequency decreases faster. With the decrease of flight altitude, the heat flux on the inner wall of the scramjet engine increases, the structural temperature rises faster, and the frequency decreases more at the same time. In addition, because the total temperature in the scramjet thermal environment changes little, the transient temperature of the engine structure at different heights finally tends to the same value, and the structural modal frequency finally tends to the same. The combustion equivalence ratio of the scramjet engine owns a great influence on the temperature of combustion chamber and nozzle. With the increase of the engine combustion equivalence ratio, the temperature of engine combustion chamber and nozzle increases, and its first-order, third-order, fourth-order and fifth-order frequencies decrease faster, while the inlet is not affected by the equivalence ratio, thus the second-order and sixth-order frequencies change little. This study can provide a strategy for predicting the full flight trajectory vibration characteristics of the scramjet engine, and provide support for the structural optimization design and vibration response reduction of the scramjet engine.
Electrospherization of genistein@DNA core-shell nanospheres as a drug delivery system and theoretical study of the release mechanism
Authors: Elsherbeny Aya A. , Motawea Amira , Tawfik Ashraf M. , Gabr Mohamed M. , Elmezayyen Ayman S.
Published: February 2023

The practical application of genistein (GEN) as a drug system is hindered by its low aqueous solubility and poor oral bioavailability. Encapsulation of poor water-soluble drug was considered as one of the widely used approaches to overcome such of these obstacles. The primary goal of this research was to in situ encapsulate the hydrophobic GEN during the electrosynthesis of DNA nanospheres as a delivery system (Es GEN@DNA) with appropriate drug release properties. The prepared Es GEN@DNA nanospheres were characterized using UV-visible spectroscopy, X-ray diffraction analysis (XRD), transmission electron microscope (TEM), zeta potential and stability test. The results revealed that GEN was successfully encapsulate in situ during the DNA electrospherization (Es GEN@DNA) as core shell like structure (Core: GEN and Shell: DNA) with a wonderful stability against time. Furthermore, the drug encapsulation % was studied. In addition, the drug release efficiency of Es GEN@DNA was recorded and theoretically visualized to understand the mechanism and kinetics of GEN drug release. %Encapsulation of GEN within DNA nanospheres was found to be 89.62%. Es GEN@DNA release profile explored that the well entrapped GEN within the DNA nanospheres could be a promising for sustained drug release. Besides, we overcome the dilemma of using a fractal or fractional kinetics model by introducing a general fractional kinetic equation that involves a time-dependent rate coefficient, which introduced that the solution of the fractional kinetic model is capable of fitting the release data profiles of free GEN and Es GEN@DNA.
Efficacy and safety of artificial liver support system treatment for immune checkpoint inhibitors related liver failure in patients with hepatocellular carcinoma: a randomized controlled clinical trial
Authors: Luo Qiumin , Zhang Yeqiong , Li Yangmei , Li Zhipeng , Chen Jia , Deng Zhexuan , Lai Jiadi , Peng Liang , Mei Yongyu , Xu Wenxiong
Published: February 2023

Background: It is well-established that immune checkpoint inhibitors-induced immune-mediated hepatitis (ICIs-IMH) in patients with hepatocellular carcinoma (HCC) increases susceptibility to liver failure (LF). Given mounting evidence that artificial liver support system (ALSS) treatment can effectively relieve both IMH and LF, a single-center, non-blinded, randomized controlled clinical trial will be conducted to investigate the efficacy and safety of ALSS for HCC patients with ICIs-LF.
Methods and analysis:Sixty participants who meet the eligibility criteria will be enrolled in this trial and randomized to one of two arms at a 1:1 ratio. In addition to comprehensive pharmacological treatment, patients in the trial group will receive treatment with double plasma molecular adsorption system (DPMAS) and low volume plasma exchange (LPE) three times, while patients in the control group will undergo PE three times. Patient evaluations, including symptoms and laboratory tests, will be performed at baseline, before and after the three times of ALSS treatment, and 2, 4, 8, and 12 weeks after enrollment. The primary outcome is the mortality rate at 12-week follow-up. The secondary outcomes include the change in the Model for end-stage liver disease (MELD) score after ALSS treatment and the incidence of adverse events (AEs).
Discussion: ICIs-LF in patients with HCC have a high mortality rate and lacks effective treatment. Our study can evaluate the efficacy and safety of ALSS for this patient population, and compare the two modes of ALSS (DPMAS+LPE vs. DPMAS).
Trial registration: ClinicalTrials.gov ID: NCT05484908 (Release Date: July 30, 2022).
Comparison of effects and brain imaging mechanisms of acupuncture and paroxetine for depressive patients with suicidal ideation: study protocol of a 20-week clinical trial
Authors: Li Qifu , Lu Yi , Sun Jinbo , Huang Gaoyangzi , Gong Yi , Zhang Bingkui , Chen Ziwen , Zhang Xinghe , Huang Ya , Zeng Xuanxiang , Zhao Siwen , Tang Xin , Pei Xianmei , Zhang Renrui , Guo Taipin , Liang Fanrong
Published: February 2023

Background Suicide is a devastating and major medical and social problem, and effective management of depression with suicidal ideation (DWSI) is of significant importance in reducing suicide rates. Acupuncture has been less studied in DWSI, and its central mechanisms have not been elucidated. This study aims to carry out a clinical trial using multimodal brain imaging techniques to investigate the mechanism of brain network regulation of DWSI by acupuncture.
Method A total of 70 patients with DWSI and 30 healthy subjects will be recruited for this study. This trial will include a 1-week baseline phase, a 12-week treatment phase, and a 8-week follow-up phase. Patients in the acupuncture group will receive 36 sessions of acupuncture, 3 times a week for 12 weeks. Patientsin the paroxetine control group will receive paroxetine 10 mg per day (week 1), 20 mg per day (weeks 2); and 30 mg per day (weeks 3-12). The primary outcomes are the mean change in the Hamilton Depression Rating Scale-24 scores and the Beck scale for suicide ideation. The secondary outcomes include the Depression Self-Rating Scale, Clinical Global ImpressionsScale, Asberg Antidepressant side effect scale and World Health Organization Quality of Life Questionaire abbreviated version. Magnetic resonance imaging data will be collected from each participant at baseline and each patient at the end of treatment.
Conclusions This study hypothesised that acupuncture therapy could treat DWSI by restoring the pathological center of suicidal ideation in brain. This study will clarify the mechanism of brain network regulation of DWSI by acupuncture.
Trial registration number ChiCTR2200059267, registered on April 7, 2022.
DMT-(S)-Pro-OSu derivatization UPLC/ESI-MS/MS is a powerful method for the comprehensive analysis of dipeptides
Authors: Ito Keisuke , Terada Yuko , Nakayama Ryoka , Shigeta Takashi , Hisada Takumi , Fujitani Masaya , Kanie Kei , Kato Ryuji , Fukui Serina , Sugiyama Eiji , Mizuno Hajime , Todoroki Kenichiro
Published: February 2023

Dipeptides are important components that contribute to the characteristics of various foods; however, the dipeptide composition of foods is poorly understood. In the present study, a new, comprehensive analysis method for dipeptides, i.e., (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidine-2-carboxylate (DMT-(S)-Pro-OSu) derivatization ultra-performance liquid chromatography–electrospray ionization tandem mass spectrometry (UPLC/ESI-MS/MS), was developed. Using the method, the analytical behavior of 313 dipeptides in the UPLC/ESI-MS/MS was collected. The obtained comprehensive dataset elucidated the dipeptide profiles in fermented cocoa beans. Furthermore, the machine learning on the dataset provided the quantitative understanding of physicochemical molecular descriptors that affect the elution time of dipeptides on the reversed-phase LC analysis, namely, an in silico elution time prediction model was successfully constructed. The DMT-(S)-Pro-OSu derivatization UPLC/ESI-MS/MS method is a powerful tool for the comprehensive analysis of dipeptides.
Parameter Estimation of a Valve-Controlled Cylinder System Model Based on Bench Test and Operating Data Fusion
Authors: Su De-Ying , Wang Shao-Jie , Lin Hao-Jing , Xia Xiao-Song , Xu Yu-Bing , Hou Liang
Published: February 2023

The accurate estimation of parameters is the premise for establishing a high-fidelity simulation model of a valve-controlled cylinder system. Although bench test data are convenient to obtain in model parameter estimation, there is a need for the load data to conform to the actual working conditions. Although the operating data include the actual load information, it is not easy to collect the control valve operating data. This paper proposes a model parameter estimation method based on bench test and operating data fusion to solve the above problems. The proposed method is based on Bayesian theory, and its core is a pool fusion of prior information from bench test and operating data. First, a system model is established, and the parameters in the model are analysed. Then, the bench test and operating data of the system are collected, and the model parameters and weight coefficients are estimated using the data fusion method. Finally, the estimated effects of the data fusion method, Bayesian method, and PSO algorithm on system model parameters are compared. The research shows that the parameter estimation result based on the data fusion method is accurate. The weight coefficient represents the contribution of different prior information to the parameter estimation result. The effect of parameter estimation based on the data fusion method is better than that of the Bayesian method and the PSO algorithm. The more complex the load is, the worse the model's accuracy, which verifies the influence of the load on the valve-controlled cylinder system model and proves that the data fusion method plays an essential role in parameter estimation studies.
Audio interventions for acute pain management – Protocol of systematic review and meta-analysis
Authors: Tololiu Kevin Efrain , Kurnianto Arie Arizandi , Csokasi Krisztina
Published: February 2023

Background: Undermanaged acute pain contributes to the development of chronic pain and reduced quality of life. Although many complementary therapies have been implemented to manage chronic pain, few studies have investigated these therapies in acute pain. As one of the digital-integrated interventions, audio-related interventions provide multi approaches that potentially affect pain levels, such as suggestive affirmation, educative information, distraction, and relaxation. This study aims 1. to screen and evaluate contemporary literature concerning audio-related interventions application to reduce acute pain, 2. To analyze how the audio interventions affect pain reduction in adults in hospital settings, and 3. To identify the critical aspects of successful audio interventions in pain reduction for adults in a hospital setting.
Method: This study will use Systematic Review and Meta-Analysis by following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines. Six online databases (PubMed, Web of Science, Cochrane library, Ovid Medline & Medline (EBSCOhost), and Embase) will be searched. This review will include RCTs of audio-related interventions to reduce the acute pain level of adults in a hospital setting. Studies published older than ten years ago, presented in non-English languages, combined with other complementary interventions, and presented with the incomplete essential statistical value of pain will be excluded. The meta-analysis will be performed using R and synthesized using the GRADE approach with risk bias assessed with the Cochrane Risk of Bias Assessment tool.
Discussion: This paper will contribute to clinical practice, specifically in the application of complementary therapies or medical technologies associated with audio-related interventions. The findings will provide crucial information on the implication of audio interventions in more effective ways.
Registration: This study is registered in INPLASY protocol 202310002. Doi: 10.37766/inplasy2023.1.0002 and under review of PROSPERO.
Effect of Ionic Spin on the Multiferroic of Orthorhombic Perovskite Structure
Authors: Gao Kaiyang , Shen Jiyu , Lu Zeyi , Mo Jiajun , Liu Guoqing , Wu Zhongjin , Gong Chenying , Xia Yanfang , Liu Min
Published: February 2023

To study the role of the spin of ions in the coupling between ferromagnetism and ferroelectricity in type II multiferroic perovskite, we used the sol-gel method to prepare multiferroic perovskite Er0.9La0.1Cr0.8Fe0.2O3(ELCFO), and through Mössbauer spectrum and magnetic testing, the macroscopic magnetic characteristics of ELCFO are explored. According to the thermal magnetic curve, we analyzed the state and change of each ionic spin in the ELCFO system in different temperature ranges. And we also explore how ionic spin causes the coupling between ferroelectricity and ferromagnetism. This paper will provide a theoretical basis for studying multiferroic perovskite and play a guiding role.
Effect of Risk Factors at Workplace on Aging: A Study based on Mendelian Randomization and Phenome-wide association
Authors: Ma Jingxuan , Lan YaJia , Wang Hongjian
Published: February 2023

Objectives
Numbers of studies have shown that human aging is related to environmental factors, among which workplace is an important living environment in people's life. However, there is still a lack of causal exploration research on the effect of workplace factors on human aging. From the perspective of genetic polymorphism, we explore the association between human aging and risk factors in the workplace,and the possible pathways of aging caused by risk factors in the workplace.
Methods
To systematically explore the association between workplace risk factors and aging, we used a two-sample Mendelian randomization method to examine the association of nine common workplace risk factors with telomere length and accelerated DNA methylation GrimAge clock. We used the corresponding single nucleotide polymorphisms screened as instrumental variables to enable causal associations between exposing to workplace factors and aging.
Results
According to our tests, "Heavy physical work" and "Noise" are associated with telomere length, which shows statistics as OR [95% CI] = -0.136[-0.229, -0.043], p = 0.004 and the OR [95% CI] = 0.014 [0.002, 0.027], p = 0.025) respectively. Meanwhile, the P value of the phenotype "Asbestos" was close to 0.05 (P = 0.059), and the OR value was OR [95%CI] = -1.098[-2.241, 0.044].The factor "diesel exhaust"(ukb-d-22615_2) associated with GrimAge acceleration was OR [95%CI] = 8.238[-0.023, 16.450], p = 0.05.
Conclusions
Our finding suggests that there existing causal relationship between workplace exposure to risk factors (noise, heavy physical activity, fuel engine exhaust) and aging.
Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV
Authors: Ray Shilpa , Narayanan Ashwathy , Vesterbacka Jan , Blennow Ola , Chen Puran , Gao Yu , Gabarrini Giorgio , Ljunggren Hans-Gustaf , Buggert Marcus , Manoharan Lokeshwaran , Chen Margaret , Aleman Soo , Sönnerborg Anders , Nowak Piotr
Published: February 2023

Although mRNA SARS-CoV-2 vaccines are generally safe and effective, in certain immunocompromised individuals they can elicit poor immunogenic responses. Among these individuals, people living with HIV (PLWH) have poor immunogenicity to several oral and parenteral vaccines. As the gut microbiome is known to affect vaccine immunogenicity, we investigated whether baseline gut microbiota predicts immune responses to the BNT162b2 mRNA SARS-CoV-2 vaccine in healthy controls and PLWH after two doses of BNT162b2. Individuals with high spike IgG titers and high spike-specific CD4+T-cell responses against SARS-CoV-2 showed low α-diversity in the gut. Here, we showed for the first time that the gut microbial composition influences the response to BNT162b2 in PLWH. Bifidobacterium and Faecalibacterium appeared to be microbial markers of individuals with higher spike IgG titers, while Cloacibacillus was associated with low spike IgG titers. We therefore propose that microbiome modulation could optimize immunogenicity of SARS-CoV-2 mRNA vaccines.
Multi-omics reveals that forage fiber promotes rumen development of pre-weaning calves compared to non-forage fiber
Authors: XU Shengyang , Wang Shuo , Zhao Wei , Bi Yanliang , Diao Qiyu , Tu Yan
Published: February 2023

Background: The rumen development of calves can result in long-term effects on growth, health, and milk yields in adult cattle. Dietary fiber supplement can stimulate rumen development in calves during pre-weaning period. Non-forage fiber can be used as starter fiber to reduce gastrointestinal fill and increase the content of rumen volatile fatty acid (VFA) because of higher biodegradable fiber. Numerous studies revealed that non-forage fiber has no negative effect on pre-weaning calves compared to forage fiber, but few evidences of rumen development were given. It is unclear whether different fiber sources impact the development of rumen in pre-weaning calves. Here, this study investigated the synergistic responses of rumen microbiota, metabolites and epithelium to different fiber source.
Results: Thirty healthy Holstein calves with similar age (4.2 ± 2.3 days) and body weight (39.2 ± 3.6 kg) were allocated to two groups (15 cows per group), and were fed with one of the two diets with different fiber sources, short oat hay (SO), or short soybean hull (SS) for 8 weeks, respectively. At the end of the experiment, 6 calves of each group with similar body weight were selected to slaughter. Observations showed that SO-feeding calves has lengthened and widened rumen epithelial papillae. Metagenomic results revealed that different bacteria responded to different fiber source by different Carbohydrate-active enzymes (CAZymes) (P < 0.05). Metabolomics analysis indicated that “vitamin B6 metabolism” pathway was significantly enriched based on the 22 increased metabolites in the SO calves (P < 0.05, pathway impact > 0.05). The Pyridoxine, 4a-Carbinolamine tetrahydrobiopterin and Gentisic acid were enriched under SO feeding (P < 0.05, VIP > 1). Transcriptome analysis revealed that 129 differentially expressed genes (DEGs) were identified from comparison of the two groups. The DEGs related to transcription, translation and energy metabolism were upregulated (P < 0.05).
Conclusions:The SO feeding (forage fiber) can lead to the enrichment of beneficial metabolites and metabolic pathways, promote the expression of genes related to energy metabolism, transcription and translation, and ultimately promote the development of rumen epithelium. Therefore, in pre-weaning calves production, attention should be paid to the impacts of forage fiber (short oat hay) introduction on rumen morphology and function.
Management and outcomes of traumatic liver injury: a tertiary care center experience
Authors: Alanezi Tariq , Altoijry Abdulmajeed , Alanazi Aued , Aljofan Ziyad , Altuwaijri Talal , Iqbal Kaisor , AlSheikh Sultan , Molla Nouran , Altuwaijri Mansour , Aloraini Abdullah , Altuwaijri Fawaz , Aldossary Mohammed Yousef
Published: February 2023

Background
Trauma is considered a significant public health problem worldwide. Abdominal trauma is generally divided into blunt and penetrating. Blunt trauma could affect any organ, and the sequelae of such injury may not always be clinically apparent. Liver injury is one of abdominal trauma's most critical and fundamental complications. We aimed to investigate the mechanism, type, and extent of injuries for patients with liver trauma and compare the outcomes between operative and non-operative management.
Methods
This retrospective study analyzed data of patients with liver injuries who presented to King Khalid University Hospital, King Saud University from 2016 to 2022. Management included conservative, conservative to laparotomy, laparotomy, and interventional radiological procedures, including hepatic artery angioembolization and percutaneous transhepatic drainage. Injury severity was graded based on the American Association for the Surgery of Trauma (AAST) liver injury scale.
Results
We analyzed 45 liver injury patients, with mean age of 29.3 years and most of them being male (77.8%). The most common injury mechanism was blunt trauma (86.7%), whereas penetrating injuries accounted only for 8.9% of cases. The most dominant type of injury was laceration (95.6%), followed by contusion (28.9%). Regarding liver injury severity, the majority of patients (37.8%) had a grade 3 injury level as per AAST liver injury scale. Among all patients, 31 (68.9%) were hemodynamically stable, whereas 14 patients (31.1%) were unstable, with a mortality rate of 2.2%. Most patients (82.2%) underwent conservative management. Six patients (13.3%) require surgical laparotomy. Two patients (4.4%) who underwent conservative management first needed surgical laparotomy. The complication rate was 24.4%, with delirium being the most common (6, 13.3%), followed by fever and sepsis (3, 6.7%) and acute renal failure, pneumonia, cardiac arrest, biliary leaks, meningitis/seizures, which were all reported in a subset of patients.
Conclusions
Liver trauma is considered a significant public health problem worldwide. The management of traumatic liver injuries has evolved significantly over the years, with the addition of interventional radiological modalities, a more inclined approach toward non-operative management.
Synthesis of the knowledge of braconids in Brazil: list of species, data gaps and spatial biases in the sampling
Authors: Moreira Gleidiany da Costa , Bosco Nicolas Silva , Shimbori Eduardo Mitio , Sobral-Souza Thadeu , Onody Helena Carolina
Published: February 2023

Understanding the distributional patterns of species is a challenge to science, mainly because knowledge of the occurrence of species is often scarce and biased. This study aimed to compile available information on the distribution of braconids in Brazil and evaluate the sampling gaps and biases using accessibility metrics. The full dataset includes 2,280 records of 1,015 species of these wasps in Brazil, distributed in 28 subfamilies and 229 genera. Opiinae is the subfamily containing the largest number of records, while Doryctinae stands out in terms of species richness. The genus with the greatest number of records is Doryctobracon Enderlein 1920, while Opius Wesmael 1835 attracts attention for its number of species. Doryctobracon areolatus (Szépligeti 1911) is the species with the largest number of records in all biomes. Most species records are from the Brazilian Southeast, especially from the Atlantic Forest. Data indicates accessibility bias towards roads, rivers, and urban centers. Implication to the conservation of insects: Our results compile the information available on the distribution of braconids in Brazil and, through them, we examined the extension of deficiencies in the sampling coverage to subsidize future studies and the prioritization of sampling areas, as well as important conservation strategies that are efficient for conservation.