bluuebunny/crossref_metadata_2025 huggingface dataset:
Sameiginlegir leikheimar barna og leikskólakennar
Authors: Hreinsdóttir Anna Magnea
Published: November 2024

Í þessari grein er fjallað um rannsókn sem hafði að markmiði að varpa ljósi á sameiginlega leikheima barna og leikskólakennara í fjórum leikskólum á Íslandi. Leikur hefur lengi verið álitinn helsta námsleið ungra barna og er talinn grundvallarréttur barna samkvæmt samningi Sameinuðu þjóðanna um réttindi barnsins (1992). Með þeim breytingum sem gerðar voru árið 2023 á Aðalnámskrá leikskóla (Miðstöð menntunar og skólaþjónustu [MMS], e.d.) er lögð aukin áhersla á sjálfsprottinn leik barna og þátttöku kennara í leiknum. Í greininni er fjallað um hvernig leikur á að byggja á áhugasviði barna og á hvaða hátt kennarar geta tekið þátt í leik. Rannsóknarverkefnið Leikheimar var þróað í fjórum leikskólum í Reykjavík út frá sameiginlegum sögum og áhuga barna og kennara í samstarfi við fjóra leikskóla í Stokkhólmi. Fræðilegur bakgrunnur rannsóknarinnar byggir meðal annars á kenningum Vygotsky (1987, 2004) um samspil kennara og barna í leik og á hugmyndum Lindqvist (1998) um sameiginlega leikheima barna og kennara. Lögð er áhersla á hlutverka- og ímyndunarleik barna sem leið til náms og þroska. Rannsóknin var tilviksrannsókn þar sem fjögur leiktilvik frá fjórum leikskólum voru skoðuð. Gagnasöfnun fól í sér frásagnir kennara af leikstundum, rýnihópaviðtöl við stjórnendur og reglulegar skráningar rannsakanda. Niðurstöður sýna að kennarar eru tvístígandi í innkomu sinni í leik barna og að börn bjóða þeim sjaldan að taka þátt í leik. Þegar kennarar taka þátt í leik barnanna þarf að gæta þess að leikurinn sé á forsendum barna til að hann verði sjálfsprottinn og skapandi. Vísbendingar eru um að þátttaka kennara í leik barna geti breytt samskiptum, eflt leik barna og aukið gleði og vellíðan. Jafnframt eru dregnar ályktanir um hvernig kennarar og leikskólastjórar geta stutt við leikmenningu í leikskólum.
Rolnictwo węglowe w łagodzeniu zmian klimatu. Praca przeglądowa
Authors: Jarosz Zuzanna , Faber Antoni
Published: November 2024

Wzrost stężenia gazów cieplarnianych w atmosferze przyczynia się do globalnego ocieplenia, a tym samym zmian klimatu. Osiągnięcie i utrzymanie w skali globalnej zerowych emisji netto antropogenicznych gazów cieplarnianych stało się podwaliną do kształtowania polityk, programów oraz działań zmierzających do neutralności klimatycznej, która warunkowana jest osiągnięciem zero emisyjności netto do 2050 r. Imperatywem jest podejmowanie działań, które umożliwią pochłanianie i ograniczenie emisji CO2 oraz będą skutkować poprawą stanu środowiska i przyczyniać się do stabilizacji klimatu. Źródło informacji opracowania stanowiły akty prawne, raporty i dokumenty instytucji międzynarodowych oraz literatura przedmiotu. Przedstawiono rolę rolnictwa w polityce klimatyczno-energetycznej Unii Europejskiej. Istotne znaczenie w łagodzeniu zmian klimatu może odegrać rolnictwo węglowe. Wskazano definicję, praktyki oraz możliwości redukcji emisji gazów cieplarnianych poprzez stosowanie działań rolnictwa węglowego.
Superstition and Its Role in Modern Business Management
Authors: Kovalchuk J. A.
Published: November 2024

Book Review: Crossman J. 2024. Superstition, Management and Organisations: Irrationality, Randomness, and Chaos in Decision Making. Palgrave Studies in Workplace Spirituality and Fulfillment. Palgrave Macmillan, Cham, 267 р. DOI: 10.1007/978-3-031-59020-7.
Perubahan Warna Pada Bahan Restorasi Resin Komposit Nanofiller Terhadap Perendaman Saliva Buatan Dengan pH 5
Authors: Widyastuti Wiena , Tri Septiani Afifa
Published: November 2024

Background: The high level of public awareness regarding aesthetic values influences the evolution and selection of restoration materials. Nanofiller composite resin is an option in aesthetic restoration because it has good aesthetic qualities, mechanical properties and high wear resistance. Color changes that occur in nanofiller composite resin are undesirable because they disturb the aesthetic value and appearance. Color changes in restoration materials are influenced by the acidic pH contained in artificial saliva. Objective: This study aims to determine the effect of artificial saliva with a pH of 5 on the color change of nanofiller composite resin restoration materials. Methods: The research object is a nanofiller composite resin with a diameter of 10 mm, and a thickness of 2mm. The research was carried out by soaking nanofiller composite resin in artificial saliva and distilled water solution. The study was divided into 2 groups, namely the treatment group and the control group. Which is placed in an incubator at a temperature of 37˚ C for 24 hours. In the control group, samples were soaked in distilled water for 24 hours, and repeated for 7 days. In the treatment group, samples were soaked in artificial saliva for 4 hours, repeated for 7 days, followed by immersion in distilled water. The color parameters of the research subjects were measured using a Vita Easyshade V spectrophotometer before and after immersion in the control and treatment groups on the 7th day. The measurement results data after carrying out the normality test, T-test (dependent), and Wilcoxon test. Results: The results of this study showed a significant color change (p<0.05). Conclusion: There is an effect of artificial saliva with a pH of 5 on the color change of the nanofiller composite resin material.
Pewarna Plak Gigi dari Pewarna Alami Buah Naga Merah, Sebuah Tinjauan Cakupan
Authors: Wesilintang Alit , Amaliya Amaliya , Cahya Prasetyo Budhi
Published: November 2024

Dental plaque identification uses disclosing agents to provide a better visual identification of dental plaque before the plaque control procedure. Studies show the use of natural ingredients for staining dental plaque, one of which is that red dragon fruit can be an effective alternative for evaluating dental plaque control. This scoping review aims to examine further natural dental plaque coloring from red dragon fruit. This literature review uses a scoping review study design that refers to the PRISMA-ScR analysis and uses the PCC framework. Article searches were carried out using key word (red pitaya) AND (disclosing agent), AND (dental plaque) in 5 online databases, namely PubMed, Science Direct, Wiley, SAGE, and Google Scholar. The selection of articles was carried out based on inclusion and exclusion criteria. Initial search obtained 170 articles, then selected according to inclusion and exclusion criteria resulting 9 articles. The results show dental plaque colorant from red dragon fruit extract can effectively color dental plaque as well as disclosing agents. Red dragon fruit extract meets the requirements for being a dental plaque coloring agent. At a concentration of 75%, red dragon fruit extract can color dental plaque well and produces optimal coloring at a concentration of 100%.
Penggunaan Asam Hialuronat untuk Penatalaksanaan Black Triangle
Authors: Tandjaja Cynthia , Astuti Luki
Published: November 2024

Introduction: The absence of interdental papilla between two teeth is called Black Triangle. It will affect the patient’s aesthethic aspect. Giving hyaluronic acid’s injection can be one of the treatment to heal the condition. Literature Review: There’s few factors that influence the absence of interdental papilla such as the length from bone crest to the contact point between two teeth. The thickness and the periodontal biotype can also effect the condition. Hyaluronic acid is one of the most biocompatible material with human body. The concentration of hyaluronic acid that got affected by the molecular weight also have their own benefit. Discussion : Hyaluronic acid will bind with water, and become the receptor of mediated cell division and will increase the tubulin concentration that is responsible to increase the proliferation of fibroblast and also the synthesis of collagen. Conclusion: Hyaluronic acid can be one of the option to heal black triangle.
Penatalaksanaan Pemasangan Dental Implant pada kasus Kehilangan Gigi Posterior Tunggal
Authors: Kartikasari Halim Aristya , Poedjiastoeti Wiwiek
Published: November 2024

Background: Tooth loss is one of the problems that patients complain about in dentist practice. Tooth loss is often found in adult patients, especially posterior teeth, i.e. premolar or molars. Implant restoration of the loss of one posterior tooth is the best option for now. Objective: To determine the good management of complication factors when installing dental implants on posterior teeth. Case and Management:  A 23-year-old male patient came to RSGM-P FKG Usakti to make a fixed denture on the left lower back tooth that had been extracted due to a tooth fracture so that chewing could be better. The patient has no systemic disease, no history of allergies, and no bad habits. There are no complicating factors at the time of dental implant placement in dental area 37, so there is good osseointegration and proper crown insertion. Conclusion: Dental implant placement in the case of posterior single-tooth loss in this patient was not found to be difficult. Dental implant restoration with single-tooth loss is the best option for now with a success rate of 97% for dental implants with posterior single-tooth loss compared to other types of implant restoration.
Penatalaksanaan kasus bimaxillary dental protrusion disertai gigi anterior berjejal berat
Authors: Nofrizal Riko
Published: November 2024

Background: Bimaxillary dental protrusion accompanied by crowding is a case of malocclusion which has high prevalence in the Asian region. Treatment of bimaxillary dental protrusion accompanied crowding case generally involves the extraction of four firat premolar to obtain the space required to correct crowding and retraction of the anterior teeth. Objective: This case report explain about the treatment of bimaxillary dental protrusion accompanied by severe crowding. Case: The patient has a convex soft tissue pofile, bimaxillary dental protrusion accompanied by severe crowding. Case treatment: Treatment begins with extracting the four first premolar to create space, so that the anterior crowding can be repositioned properly. The anterior retraction is performed to correct the convex facial profile. After 20 months of treatment, the patient’s occlusion and aesthetics improved. Conclusion: An appropriate treatment plan is very necessary for the treatment of bimaxillary dental protrusion accompanied by severe crowding to obtain maximum treatment results
Tendencia de Complicaciones en Diabetes Tipo I y II: Impacto de la pandemia por COVID-19 en un Hospital de referencia en Antioquia (2018-2023)
Authors: Gonzalez Sanchez Ana Maria , Perez Aguirre Carlos Andres , Zambrano Juanvilson A. , Diaz Paula Andrea , Barengo Noel
Published: November 2024

Objetivo: Analizar la tendencia temporal de complicaciones diabéticas en pacientes con diabetes tipo I(DM1) y II(DM2) en un hospital de referencia en Antioquia durante período prepandémico, pandémico y pospandémico (2018-2023). Métodos: Estudio observacional analítico transversal repetido de historias clínicas de DM1 y DM2 en un hospital de Antioquia, obtenidos a través de Clinerion y Servinte, en tiempo prepandémico (01/01/2018-10/03/2020), pandémico (11/03/2020-05/05/2023) y pospandémico (05/06/2023-31/12/2023). Se realizó regresión de Poisson bayesiana evaluando complicaciones en DM1 y DM2 y regresión logística bayesiana para estimar probabilidad de mortalidad con medias e intervalos de credibilidad ajustados por periodo y sexo. Resultados: Se obtuvieron 20.730 registros (10.155 para DM1, 10.575 para DM2). La frecuencia anual de complicaciones en DM1 aumentó de 791,9 (ICr99%724,7–863,1) en prepandemia a 973,9 (ICr99%910,1–1038,6) en pandemia, mientras que en DM2 el aumento se observó de 1307,8 (ICr99%1233,6–1383,1) en pandemia a 1909,6 (ICr99%1719,7-2113,3) en pospandemia. La probabilidad de morir para DM1 en mujeres, pasó de 0.09 (ICr99%[0.08- 0.11]) en prepandemia a 0.13 (ICr99%[0.12-0.15]) en pospandemia y en hombres de 0.08 (ICr99%[0.07-0.10]) a 0.12 (ICr99%[0.11-0.14]) y en mujeres con DM2 incrementó de 0.10 (ICr99%[0.09-0.12] a 0.15 (ICr99%[0.13-0.17]) y en hombres de 0.09 (ICr99%[0.08-0.11]) a 0.14 (ICr99%[0.12-0.16]). Conclusión: Se encontró aumento de complicaciones en DM1 durante y después de la pandemia, y en DM2 de pandemia a pospandemia, a pesar de no contar con diagnóstico de COVID-19. La mortalidad aumentó en ambos grupos durante la pandemia. Es crucial adaptar estrategias para esta población y continuar investigando complicaciones en diferentes períodos y contextos.
Análisis de la Mortalidad por Cáncer en Colombia (2003-2019) Un Estudio Poblacional mediante Modelos de Conteo Bayesiano
Authors: Perez Aguirre Carlos Andres , Zambrano Juanvilson A. , Gonzalez Sanchez Ana Maria , Diaz Paula Andrea
Published: November 2024

Objetivo: Estimar la tasa bruta de mortalidad por 100.000 habitantes desarrollando y aplicando un modelo estadístico jerárquico. Este modelo tiene en cuenta las variaciones en el tipo de cáncer, el grupo de edad, el género y las tendencias temporales, con el objetivo de proporcionar estimaciones de mortalidad precisas que puedan informar las políticas de salud pública y las estrategias de asignación de recursos. Métodos: Se realizó un estudio transversal utilizando datos de incidencia de cáncer de la plataforma Infocancer para el período 2003-2019. Se llevó a cabo una caracterización sociodemográfica de la población con estadísticas descriptivas y se aplicaron modelos bayesianos de conteo para analizar las tasas de mortalidad. Con la base de datos obtenida en infocancer se aplicó un modelo estadístico que incluyo IIntercepto para cada tipo de cáncer, efecto de la edad, efecto del género, pendiente para en año, año y población en riesgo. Resultados: El modelo estadístico jerárquico estimó eficazmente las tasas brutas de mortalidad por cada 100.000 habitantes y mostró sólidas capacidades predictivas. Al tener en cuenta el tipo de cáncer, el grupo de edad, el género y las tendencias temporales, el modelo proyectó con precisión las tasas de mortalidad futuras. Esta capacidad de previsión permite una mejor planificación de las intervenciones de salud pública y la asignación de recursos, respaldando medidas proactivas contra los patrones de mortalidad previstos. Conclusiones: El modelo jerárquico desarrollado en este estudio tiene capacidades predictivas, Al permitir predicciones individuales de mortalidad futura para cada tipo de cáncer, el modelo permite realizar pronósticos más precisos. Este avance respalda intervenciones de salud pública específicas y una mejor asignación de recursos, lo que en última instancia ayuda a la planificación estratégica para abordar las tendencias de mortalidad previstas en la atención del cáncer.
“Venha Teu Reino!”
Authors: Schwambach Claus
Published: November 2024

Taking Luther's Larger Catechisms as the primary source and point of reference, the article aims to find elements of what we might call “Lutheran theology of mission” in the Reformer's own texts. In light of Luther's well-known finding by researchers, that interpretation of Luther's second petition of the Lord's Prayer, especially in the Large Catechism, may serve as an important reference for understanding what Luther understands by what we today call mission, the study aims to interpret the details of the Lord's second petition. In conclusion, the article systematizes the emphases found in Luther, aiming to offer connections to contemporary missiological discussions.
Processo de aprendizagem na fé
Authors: Wischral Rodrigues Marilze
Published: November 2024

The dialogue between theology and pedagogy builds the basis for the development of the learning process from the perspective of faith. It is not faith that grows, but rather people who mature in attitudes that correspond to the hope they confess, concrete attitudes in their daily lives. Considering the cognitive, affective and attitudinal dimensions of the human being, this research has as its main objective to describe learning that is integral, significant and continuous, from the perspective of faith. Therefore, in addition to bibliographical research, an exegetical analysis of biblical texts that support each of these learnings was carried out. It is important to consider the existential context of students, establishing the link between faith and life, promoting integral, significant learning and continuous formation in the faith, that is, in each phase of life. The task of continuous formation in the faith is the responsibility of all people who participate in life in the Christian community, evidencing the general priesthood of all people who believe in an effective and efficient way. The Church of Jesus Christ is concerned with the catechumenate, with ongoing discipleship, with the formation in the faith of children, adolescents and young people, as well as adults and the elderly, planning and implementing in a conscious and responsible way the integral and significant learning in the process of formation in the faith throughout life.
Immediate effect of dynamic stretching with and without floss band on hamstring flexibility in futsal players: A pilot study
Authors: Zaidi Shiza F. , Sadiq Noman , Abbas Muhammad Farrukh , Galal Dina O. S. M.
Published: November 2024

Objectives:

The objective of this study was to assess the immediate impact of dynamic stretching with and without floss band on hamstring flexibility in futsal players.

Methods:

Fifty-four players were included and randomly divided into tissue flossing and non-tissue flossing groups. Both groups performed dynamic stretching of the hamstring muscle, three sets of 15 repetitions. Active knee extension (AKE), straight leg raise (SLR), and sit-and-reach tests were conducted before and after the intervention. Blood samples were also drawn pre- and post-intervention to determine serum creatine kinase (CK) and lactate dehydrogenase (LDH) for recording muscle damage.

Results:

On comparing the results of both groups, the tissue flossing group had significantly increased scores (left leg P = 0.005, right leg P = 0.007) for the AKE and sit-and-reach tests (P = 0.017). The two groups had no significant SLR, CK, or LDH disparity (P > 0.05). On the other hand, within-group comparisons showed a significant disparity (P < 0.05) between all variables in both groups.

Conclusion:

The present study revealed that dynamic stretching with and without a floss band improved hamstring flexibility by increasing AKE, SLR, and sit-and-reach tests; however, results were significantly improved with a floss band. Compared to dynamic stretching without flossing, flossing resulted in better improvement of AKE and sit-and-reach test scores, while serum CK and LDH remained the same for both groups.
Total sacrectomy rehabilitation: Implementation of the international classification of functioning, disability, and health model – A case report
Authors: Lopes Alfredo A. , Mesquita Inês , Torres Rui
Published: November 2024

This study aims to outline an evaluative diagnostic process and intervention for a patient who underwent total sacrectomy based on the International Classification of Functioning, Disability, and Health (ICF) model. A 70-year-old male with a history of an aggressive sacral chordoma experiencing intense pain, constipation, and polyuria without the sensation of bladder filling, underwent a total sacrectomy. Two evaluations at two-time points were conducted 12 weeks apart. The patient then underwent an individualized rehabilitation program tailored to address impairments, activity limitations, and participation restrictions. The care plan was adjusted based on the patient’s health status and relevant personal and environmental factors. The Barthel Scale scores improved from 60 to 80. Motor scores on the American Spinal Injury Association scale increased from 62 to 66, while sensory scores for light touch improved from 86 to 96. However, pain scores remained stable at 86. Functional reach tests showed notable enhancements, with anterior reach increasing from 16.4 cm to 23.7 cm and lateral reach from 9.6 cm to 15.2 cm. The patient also showed progress in mobility, increasing the number of steps taken from 0 to 10. This case report highlights the positive therapeutic outcomes achieved, illustrating improvements in functional activities and patient independence, thereby underscoring the effectiveness of the ICF model in managing patients undergoing total sacrectomy.
Multivalvular prolapse: A case report of concurrent mitral, aortic, and tricuspid valve involvement in the same patient with severe regurgitation and heart failure features
Authors: Gaurab Vishal , Bhattacharjee Manna , Prakash Sai Durga
Published: November 2024

Myxomatous valvular disease of cardiac valves has been reported in various studies and case reports which involves mainly mitral valve. This valvular involvement produces several degrees of regurgitant lesions, causing symptoms. Concomitant involvement of mitral, aortic, and tricuspid valves has been rarely reported. Here, we report a case of a 49-year-old male with triple valve prolapse, presenting with dyspnea and palpitations. The patient was managed conservatively as he was not fit for surgical intervention. This report adds to the limited data available in the literature and current guidelines to support clinical decision-making.
A rare case of cerebellar abscess caused byNocardia cyriacigeorgica
Authors: Koruga Nenad , Reljac Gordan , Rončević Alen , Bogdan Maja , Sabadi Dario , Farčić Nikolina , Rotim Tatjana , Turk Tajana , Rončević Robert , Soldo Koruga Anamarija , Dmitrović Branko
Published: November 2024

Background:

Gram-positive opportunistic bacteria of theNocardiaspecies are responsible for a large spectrum of infections, such as pneumonia, skin infections, and more widespread conditions, including brain abscesses.

Case Description:

A 67-year-old male patient suffered from headache, gait disorder, and vertigo for a week before admission to our department. An enhanced magnetic resonance imaging scan revealed a mediosagittal hyperintense infratentorial lesion with concomitant compression of the fourth ventricle. The patient underwent surgical treatment with general anesthesia. The frozen section did not reveal any tumoral tissue but rather a purulent content. He was comatose on the 1stpostoperative day, and he underwent a follow-up computed tomography (CT) scan, which revealed triventricular hydrocephalus. The external ventricular drain was performed, and a follow-up CT scan revealed significant improvement of hydrocephalus. Matrix-Assisted Laser Desorption Ionization Time of Flight did not reveal any causative agent from the intraoperative content, but the 16s ribosomal DNA method confirmedNocardia cyriacigeorgica. The patient was intravenously treated with ceftriaxone and trimethoprim/sulfamethoxazole and died on the 5thpostoperative day.

Conclusion:

Nocardiosis presents a rare Gram-positive bacterial infection that typically affects immunocompromised hosts.Nocardia-caused brain abscesses present a significant challenge in its treatment for its atypical presentation and slow culture growth.
АНАЛИЗ СОЦИАЛЬНОГО ФАКТОРА, ОКАЗЫВАЮЩЕГО ВЛИЯНИЕ НА ПОТРЕБИТЕЛЬСКИЙ СПРОС
Authors: Н.А. Волкова , Н.Т. Катанаев
Published: November 2024

Работа направлена на решение проблем, связанных с влиянием социального фактора на платежеспособный потребительский спрос. Одним из основных социальных факторов является неравномерность распределения доходов (НРД), которая исследуется с помощью линейной и нелинейной расчетной схемы распределения доходов среди разных слоев населения. Также рассматривается семейство прямых неравномерности, построенных для различных показателей, которое позволяет конкретно решить задачу оценки влияния неравномерности распределения доходов на зону платежеспособного совокупного спроса.
РОЛЬ НАЛОГОВОГО КОНТРОЛЯ В ГОСУДАРСТВЕННОМ ФИНАНСОВОМ КОНТРОЛЕ
Authors: Н.А. Волкова , О.А. Бойченко
Published: November 2024

Государство выполняет свои обязанности, обеспечивая выполнение социально-экономических программ на различных уровнях, централизованно распределяя финансовые ресурсы, что влечет за собой финансовый контроль за их формированием и распределением. Финансовый контроль является элементом управления финансовыми потоками и должен быть осуществлен специально созданными органами, которые несут ответственность за полное соблюдение законодательства всеми гражданами страны.
СОЦИАЛЬНО-ПСИХОЛОГИЧЕСКИЕ АСПЕКТЫ САМОЗАНЯТОСТИ В ПЕРИОД ПАНДЕМИИ
Authors: Е.Ю. Елисеева , Ю.А. Елисеев
Published: November 2024

В рамках данной статьи автором рассматривается такое явление, как самостоятельная занятость населения в разрезе её развития в период пандемии, а также тесной взаимосвязи с социально-психологическими аспектами жизнедеятельности. Цель данного исследования заключается в проведении комплексного теоретического анализа социально-психологических аспектов самозанятости граждан в период влияния пандемии COVID-19. Для достижения поставленной цели были задействованы методы анализа и синтеза литературных источников; кроме того, особенно важными выступили эмпирические методы – сравнение, обобщение, абстрагирование, наблюдение и ряд других. Результаты проведенного анализа позволяют отметить, что социально-психологические аспекты самозанятости населения вызваны резким изменением традиционного жизненного уклада, возникшего в период коронавирусной инфекции. Так, влияние социальных, экономических, психологических, эпидемиологических, а также ряда других факторов, привело к снижению эмоционального состояния населения – возникла неуверенность в будущем, сопровождающаяся возросшим уровнем тревожности, раздражительности и неопределенности. Одним из способов частичного нивелирования данных факторов стало такое явление, как самостоятельная занятость.
РАЗВИТИЕ ТРАНСПОРТНО-ЛОГИСТИЧЕСКОГО КЛАСТЕРА КАЛУЖСКОГО РЕГИОНА В УСЛОВИЯХ ВНЕШНЕЭКОНОМИЧЕСКИХ «БЛОКИРАТОРОВ»
Authors: Т.Х. Мамедли , А.А. Мигел , А.А. Остроумов
Published: November 2024

Ключевым фактором успешного развития страны в целом и регионов в частности выступает положительная динамика внешнеэкономических связей. Несмотря на «форс-мажорные» западные санкции, трудности в поддержании устойчивости сложившихся много ранее торгово-экономических взаимодействий, нельзя отменить ставку на расширение экспортно-ориентированного сегмента российского бизнеса. Региональные кластерные модели остаются эффективным механизмом привлечения инвестиций и активизации экономической интеграции со странами-партнерами.  Так, развитию экспортного потенциала Калужского региона, обладающего соответствующими характеристиками и возможностями, способствует формирование транспортно-логистического кластера. Закрытие границ, фактическое ограничение торговли с западными странами и санкции, введенные против РФ, безусловно, повлияли на состояние транспортной логистики региона. Ощутимым стало увеличение стоимости запчастей, сервисного обслуживания грузового транспорта и самих транспортных средств. Подобные изменения неизбежно ведут к росту себестоимости рейсов, соответственно, повышаются и цены для заказчиков грузоперевозок, что приводит к удорожанию поставляемой продукции, понижению реальных доходов потребителя. Реализация перспектив транспортно-логистического кластера Калужской области возможна исключительно при условии учета новых реалий и принятия адаптационных решений.
Variants of surgical tactics and structural changes in the esophageal wall in the Burhaave syndrome
Authors:   Astrakhan State Medical University, Astrakhan, Russia, Demaldinov D.A. , Mustafin R.D. ,   Astrakhan State Medical University, Astrakhan, Russia, Kurtusunov B.T. ,   Astrakhan State Medical University, Astrakhan, Russia, Rozhkova S.V. ,   Pathoanatomical bureau, Astrakhan, Russia
Published: November 2024

Two clinical cases of surgical tactics options for Burhaаve syndrome (spontaneous perforation of the esophagus) are presented. The assessment of the status of patients, the nature of interventions, the results of histological examination and the outcomes of the disease was carried out. In both cases, the reason for hospitalization in the thoracic department was a spontaneous rupture of the esophagus, complicated by mediastinitis and pleural empyema. The first patient, 59 years old, underwent esophageal extirpation with the imposition of gastro- and esophagostomy. Сlinical recovery has been achieved with the reconstructive surgery was performed. The second patient, 69 years old, underwent conservative treatment. On the 7th day, there was an arrosive bleeding. A thoracolaparotomy and suturing of the esophageal defect were urgently performed. In the postoperative period, there was a progressive deterioration with the death for the esophageal sutures leak and coronary syndrome.
Possibilities of surgical treatment of locally advanced colon cancer
Authors:   Federal State Budgetary Educational Institution of the Ryazan State Medical University of the Ministry of Health of Russia, Ryazan, Kaminskij Yu.D. ,   State-Funded Institution Ryazan Regional Clinical Oncological Dispensary, Ryazan, Kulikov E.P. ,   Federal State Budgetary Educational Institution of the Ryazan State Medical University of the Ministry of Health of Russia, Ryazan, Botov A.V. ,   State-Funded Institution Ryazan Regional Clinical Oncological Dispensary, Ryazan, Miheev A.V. ,   Federal State Budgetary Educational Institution of the Ryazan State Medical University of the Ministry of Health of Russia, Ryazan,   State-Funded Institution Ryazan Regional Clinical Oncological Dispensary, Ryazan, Plotnikova O.A. ,   Federal State Budgetary Educational Institution of the Ryazan State Medical University of the Ministry of Health of Russia, Ryazan, Sharapov D.A. ,   State-Funded Institution Ryazan Regional Clinical Oncological Dispensary, Ryazan, Shustov A.E. ,   State-Funded Institution Ryazan Regional Clinical Oncological Dispensary, Ryazan
Published: November 2024

In this article a clinical case of a patient with locally advanced colon cancer is presented. The necessity and expediency of performing multivisceral colon resection are discussed. In colon cancer involving neighboring organs and soft tissues, secondary lesions are limited in nature, which makes it possible to consider the possibility of performing organ-preserving surgical interventions. A patient with a tumor of the splenic bend of the colon with signs of extraorgan spread underwent a combined left-sided hemicolectomy with longitudinal resection of the stomach, resection of the left dome of the diaphragm with an atypical resection S4. 5 of the left lung, splenectomy. The postoperative period was uneventful. He satisfactorily underwent 4 courses of adjuvant chemotherapy according to the XELOX regimen. With dynamic observation, no data for recurrence was obtained, and stabilization of the process was achieved. The patient currently feels satisfactory and leads an active lifestyle.
Academician Donat Semenovich Sarkisov – an outstanding pathologist (on the 100th anniversary of his birth)
Authors:   Pirogov National Medical and Surgical Center, Moscow, Shevchenko Yu.L. , Deev R.V. ,   A.P. Avtsyn Research Institute of Human Morphology of B.V. Petrovskiy National Research Centre of Surgery, Moscow, Matveev S.A. ,   Pirogov National Medical and Surgical Center, Moscow, Dzhalaev F.Sh. ,   Pirogov National Medical and Surgical Center, Moscow
Published: November 2024

А brief biography of Academician Donat Semenovich Sarkisov and his contribution to the development of medical and biological sciences is presented.
The influence of cardiovascular – renal – metabolic syndrome and separately cardiorenal syndrome on the course of coronary heart disease
Authors:   Dagestan State Medical University, Makhachkala, Khabchabov R.G. , Makhmudova E.R. ,   Dagestan State Medical University, Makhachkala, Abdullaev A.A. ,   Dagestan State Medical University, Makhachkala, Gafurova R.M. ,   Dagestan State Medical University, Makhachkala, Islamova U.A. ,   Dagestan State Medical University, Makhachkala, Dzhanbulatov M.A. ,   Dagestan State Medical University, Makhachkala, Anatova A.A. ,   Dagestan State Medical University, Makhachkala
Published: November 2024

Objective. To identify differences between the cardiovascular – renal – metabolic syndrome and separately cardiorenal syndrome on the course of coronary heart disease. Methods. The study included 111 patients – 71 (59.5%) men and 40 (40.5%) women who were treated at the RCH Hospital No. 2 from 2022 to 2023. The patients were divided into two groups, group 1 included n = 52 with cardiovascular – renal – metabolic syndrome, group 2 included n = 59 with cardiorenal syndrome. The duration of the study is 18 months. Statistical processing of the obtained data was carried out using Excel and Statistica 7.0 programs. Results. Thus, the primary indicators of LDL cholesterol in the 1st group were 2.9±3.6, in the 2nd group 2.2±3.7 (p = 0.08), and upon re – examination, the ratio of values was as follows – 3 .2±2.8 to 32.7±3.9 (p = 0.06). There was an increase in total cholesterol and triglycerides, and indicators of good HDL cholesterol remained virtually unchanged p<0.05. Patients with stage 2 diabetes mellitus increased by the end of the examination in both groups, but so significantly in relation to the total weight of 2.7% to 1.8%, p = 0.01. During the repeated examination, the indicators of arterial hypertension of the 2nd degree prevailed in the group with cardiovascular – renal – metabolic syndrome 34.6 to 23.7 p = 0.01. But, both upon admission and during re – examination, the increase in arterial hypertension of the 3rd degree exceeded in patients with cardiorenal syndrome 25.0 to 27.1 p = 0.04. The development of acute myocardial infarction predominated in the group with cardiovascular – renal – metabolic syndrome, and the number of repeated events of coronary heart disease, the ratio was 33.6 to 23.4 p = 0.05. Conclusion. Our study showed that patients with cardiovascular – renal – metabolic syndrome are hospitalized faster and have recurrent development of coronary heart disease. As for deaths, they were equal in patients with cardiovascular – renal – metabolic and cardiorenal syndrome.
Short-term results of surgical treatment of femoroacetabular impingement with open surgical dislocation of the femoral head
Authors:   University clinic of FSBEI HE «Privolzhsky Research Medical University» MOH Russia, Nizhny Novgorod, Gerasimov E.A. , Morozova E.A. ,   University clinic of FSBEI HE «Privolzhsky Research Medical University» MOH Russia, Nizhny Novgorod, Korolev S.B. ,   University clinic of FSBEI HE «Privolzhsky Research Medical University» MOH Russia, Nizhny Novgorod, Gerasimov S.A. ,   University clinic of FSBEI HE «Privolzhsky Research Medical University» MOH Russia, Nizhny Novgorod
Published: November 2024

Rationale: three methods are used for surgical correction of femoroacetabular impingement (FAI): surgical dislocation of the femoral head (Dann-Ganz operation), minimally invasive technique with direct anterior access (mini-open operation) and arthroscopic intervention. The aim of the study was to evaluate the results of treatment of FAI with open surgical dislocation within 12 months after surgery. Material and methods: a single-center, prospective, controlled, non-comparative study was conducted. From 2019 to 2021, 30 patients with FAI underwent open surgical dislocation. The results of treatment were evaluated using radiation research methods, magnetic resonance diagnostics and patient questionnaires using the iHOT12, HOOS, and VAS scales. Statistical data analysis was carried out using Microsoft Office Excel 2010 and Statistica 12 STATSOFT programs. To assess the normality of the data distribution, the Q–Q Plot and the Shapiro-Wilk criterion were used. Quantitative data are presented in the form of M±SD (where M is the average value, SD is the standard deviation). Qualitative data are presented in the form of P±σp (where P is the percentage, σp is the standard deviation of the percentage). Qualitative indicators were analyzed using conjugacy tables and the Pearson Chi-square criterion with the Yates correction. The data were considered statistically significant at p≤0.05. Results: it was possible to achieve the angle-alpha indicators close to the target values. Analysis of gait biomechanics and scores on the iHOT12 and HOOS scales before and after surgery revealed no statistically significant differences. During the follow–up period, complications were revealed: avascular necrosis of the femoral head – 3 (10%), non–fusion of the osteotomy zone of the great trochanter - 1 (3,3%), heterotopic ossification of the abductor muscles – 1 (3,3%), persistent postoperative pain syndrome – 4 (13,3%). Conclusion: performing an open surgical dislocation with FAI makes it possible to achieve complete correction of deformity. However, a significant number of complications indicates the need to consider minimally invasive techniques, such as arthroscopic correction and mini-open surgery.
FEATURES OF ANTIVASOPROLIFERATIVE THERAPY AFTER SUBMACULAR SURGERY WITH VITREOUS PRESERVATION
Authors: Bosov E. D. , Bogdanova V. A. , Saraeva S. N.
Published: November 2024

Rationale: Age-related macular degeneration in the modern world is one of the leading problems leading to blindness. It is a rapidly progressive disease characterized by damage to the central area of the retina.

Objective: The aim of the study was to evaluate the morphological and functional parameters of the retina after surgical treatment of submacular hemorrhages against the background of anti-vasoproliferative therapy in patients with a wet form of age-related macular degeneration.

Methods: The study was conducted on the basis of the Ophthalmology Center NMHC named by Pirogov (Moscow). It included 90 participants with an active form of age-related macular degeneration. The average age of the patients was 71.3 ± 8.5 years, including 50 women aged 61 to 82 years and 40 men aged 74 to 78 years. The rationale for the use of the “treat and extend” strategy in this work is the possibility of using fewer intravitreal injections compared to a fixed scheme that gives similar results of visual functions.

Conclusion: It can be concluded that the preservation of the vitreous body during minimally invasive vitreoretinal intervention allows you to adhere to the “treat and extend” mode without reducing the inter-injection interval.
REHABILITATION AFTER SURVIVING OCULAR ONCOLOGY. LITERATURE REVIEW
Authors: Pham T. Z. , Frolov M. A. , Shklyaruk V. V. , Melnichenko S. V.
Published: November 2024

New drugs and methods of early diagnosis of malignant tumors of the visual organ have appeared in the last decades. Nevertheless, the problem of untimely diagnosis and treatment of these diseases remains in practical ophthalmology, which leads to more radical and less organ-preserving methods of treatment and, as a consequence, to the deterioration of cosmetic and functional results in subsequent eye prosthetics.

Aim. To analyze and discuss the literature on the following topics: ocular prosthetics and ophthalmic oncology using available databases.

Material and methods. Optimization of domestic and foreign scientific papers using eLibrary, PubMed, ScienceDirect and Google Scholar databases.

Results. The 52 most relevant sources of domestic and foreign literature were analyzed.

Conclusions. Having analyzed the literature data in domestic and foreign sources, we can conclude that the world medical community has not fully disclosed the issue of eye prosthetics in patients after oncological treatment. More research and practical recommendations are needed in this area. The use of a staggered prosthetic method, as well as the shape of the eye prosthesis, taking into account the individual characteristics of the conjunctival cavity, will help to achieve the best results.
ANTI-VEGF THERAPY FOR DIABETIC RETINOPATHY
Authors: Chekhonin E. S. , Pavlovskiy O. A.
Published: November 2024

Diabetic retinopathy is one of the most severe complications of diabetes mellitus, requiring the participation of doctors of various specialties: endocrinologists, diabetologists, therapists, cardiologists, surgeons, anesthesiologists and others.

The task of an ophthalmologist is to identify pathological changes in the eye associated with diabetes mellitus and prescribe appropriate treatment.

There are three main methods for treating diabetic retinopathy: 

laser coagulation of the retina;

intravitreal injections of anti-VEGF and glucocorticoids;

vitreoretinal surgery.

This literature review examines the use of vascular endothelial growth factor inhibitors in the treatment of diabetic retinopathy. In particular, it discusses the most relevant drugs, the most important studies on the therapy of DR and diabetic macular edema, as well as a post hoc analysis of these studies. In addition, the role of these drugs in the therapy of refractory DME is discussed.
ROLE OF ISCHEMIA IN THE PATHOGENESIS OF DIABETIC VITREOPAPILLARY TRACTION SYNDROME
Authors: Babaeva D. B. , Shishkin M. M. , Fayzrakhmanov R. R.
Published: November 2024

Objective: to evaluate the role of ischemia in the pathogenesis of diabetic vitreopapillary traction syndrome.

Material and methods: The analysis is based on a sample of 30 patients with diabetic vitreopapillary traction syndrome. The study included a standard ophthalmological examination, color doppler mapping, fluorescent angiography. All patients underwent three-port vitrectomy to eliminate traction syndrome.

Results: The results of the obtained data indicated that patients with diabetic vitreopapillary traction syndrome had significant changes in the hemodynamics of the eye compared to the normal parameters. A significant difference in a blood flow parameters in the posterior short ciliary arteries system was recorded in eyes with vitreopapillary traction syndrome compaired to paired eyes.

Conclusion: The results of the studies indicate that patients with diabetic vitreopapillary traction syndrome have significant changes in regional hemodynamics: a decrease in blood flow velocity in the central retinal artery, posterior short ciliary arteries and an increase in peripheral vascular resistance, which indicates ischemia of the optic nerve head and may also be one of the reasons for the development of vitreopapillary traction.
INTERNAL LIMITING MEMBRANE PEELING IN CASE OF RHEGMATOGENOUS RETINAL DETACHMENT AS A PREVENTIVE MEASURE FOR EPIRETINAL MEMBRANE
Authors: Klev V. S. , Fayzrakhmanov R. R. , Shishkin M. M. , Sekhina O. L. , Vaganova E. E.
Published: November 2024

Rhegmatogenous retinal detachment (RRD) is one of the general determinants of the primary sight disability. However, employable people represent the majority of patients with RRD.

Over the past 50 years, retinal detachment surgery had rapid progress, and the rate of success surgery increased up to 90% and higher. However, reducing the risks of reoperations, improving functional outcomes and increasing postoperative visual acuity remain topical issues at present.

The main reason for second surgical interventions is progression of the proliferative vitreoretinopathy, which can lead to epiretinal membrane, macular oedema, and to recurrence of the retinal detachment.

We reviewed current literature studies that report the results of internal limiting membrane peeling in cases with RRD and other alternative techniques aimed at reducing the risk of mentioned above postoperative complications.
ACUTE RETINAL PIGMENT EPITHELIITIS: CLINICAL CASES
Authors: Kolesnikova E. T. , Ivanov S. V. , Komissarov A. V.
Published: November 2024

Acute retinal pigment epitheliitis is a rare idiopathic inflammatory disease of the retina that occurs most often in young healthy patients. The article presents three clinical cases with the results of dynamic observations.
INVESTIGATION OF CHANGES IN LENS THICKNESS DEPENDING ON INTRAVITREAL ADMINISTRATION OF ANGIOGENESIS INHIBITOR AND DEXAMETHASONE DEPOT
Authors: Lais Alkharki , Matyuschenko A. G.
Published: November 2024

Currently, the frequency of intravitreal injections (IVV) has a steady upward trend. Antiangiogenic therapy is the predominant method of treating various retinal pathologies. Intravenous injections using pharmacological drugs against VEGF, as well as the intravitreal dexamethasone implant “Ozurdex” are widely used. Since the effect of these pharmacological drugs on cataractogenesis has not yet been sufficiently studied, research in this area is of paramount importance for understanding the morphological characteristics associated with cataract progression. Purpose: The purpose of this study is to study fluctuations in lens thickness during intravitreal administration of aflibercept and dexamethasone depot. Materials and methods. A total of 220 eyes were included in the study. Based on the administered pharmacological drug, the first group included 100 eyes that were intravenously injected with aflibercept, the second group received an intravitreal implant of dexamethasone Ozurdex, and the control (third) group included 100 eyes. Results: The dynamics of changes in lens thickness was documented in groups of patients treated with Ozurdex for 3-6 months (0.012), indicating a gradual increase in lens thickness in this group. Conclusion: no statistically significant changes in lens thickness were found in patients receiving aflibercept after 3 and 6 months. Conversely, the cohort receiving dexamethasone depot showed a statistically significant increase in lens thickness after both 3 and 6 months compared with the control group and the aflibercept cohort.
ACTUALIZATION AUTOSCLEROKERATOPLASTY IN CORNEAL DISEASES
Authors: Laptev N. E. , Lapteva A. V.
Published: November 2024

Rationale: Diseases of the cornea of the eye account for a quarter of the total incidence of ophthalmological pathologies, which, in turn, are detected in 11% of all cases of appeals. These pathologies are dangerous, since 75% of patients with this group of diseases may subsequently develop visual impairment, up to its complete loss. In case of severe lesions, surgical intervention is inevitable, while both allo- and autografts can be used for corneal flap transplantation, with the sclera being the most preferred option in this case. Autosclerokeratoplasty seems to be a modern, most rational method for treating severe pathologies of the cornea, and updating this method seems to be a very important task.

Objective: updating the method of autosclerokeratoplasty for corneal lesions using a clinical example of the successful use of the method for ulcerative lesions of the cornea.

Methods: An analytical work of scientific literature for the last 10 years was carried out, PubMed databases were used, including PubMed Central, Google Scholar, CyberLeninka. The search was conducted using the keywords “autosclerokeratoplasty”, “autosclera”, “corneal ulcer”, etc.

To characterize the possibility of using autosclerokeratoplasty in clinical practice for corneal damage, a clinical case is given, medical documentation was used for the analysis: outpatient card, medical history, instrumental and physical examination data. The data were systematized using modern methods of information analysis.

Results: The method has many advantages over other methods of surgical treatment of corneal pathologies: 1) performing anterior lamellar keratoplasty of the cornea allows to reliably close the optical zone, eliminating the threat of perforation and in some cases improve the patient’s vision, 2) in case of a threat of rejection of the lamellar keratograft, it is possible to take a second peripheral fragment of the cornea under the upper eyelid, 3) suture fixation of the autoscleral flap over the area ofthe corneal defect under the upper eyelid allows to achieve an aseptic course of the process, 4) the location of the area for taking the lamellar keratograft under the upper eyelid does not worsen the cosmetic appearance of the operated eye. Based on a clinical case with a severe patient, the potential of this operation is visible.

Conclusion: autosclerokeratoplasty is a progressive method of surgical treatment of corneal pathologies. Since the incidence of these pathologies is high, and the risk of disability is high, the actualization of this method is most important. At the same time, all the current data on the possibilities of autosclerokeratoplasty are provided based on scientific literature and a clinical case.