bluuebunny/crossref_metadata_2025 huggingface dataset:
Cyclical aggregation extends in vitro expansion potential of human mesenchymal stem cells
Authors: Bijonowski Brent M. , Yuan Xuegang , Jeske Richard , Li Yan , Grant Samuel C.
Published: November 2020

Mesenchymal stem cell (MSC)-based therapy has shown great promises in various animal disease models. However, this therapeutic potency has not been well claimed when applied to human clinical trials. This is due to both the availability of MSCs at the time of administration and lack of viable expansion strategies. MSCs are very susceptible to in vitro culture environment and tend to adapt the microenvironment which could lead to cellular senescence and aging. Therefore, extended in vitro expansion induces loss of MSC functionality and its clinical relevance. To combat this effect, this work assessed a novel cyclical aggregation as a means of expanding MSCs to maintain stem cell functionality. The cyclical aggregation consists of an aggregation phase and an expansion phase by replating the dissociated MSC aggregates onto planar tissue culture surfaces. The results indicate that cyclical aggregation maintains proliferative capability, stem cell proteins, and clonogenicity, and prevents the acquisition of senescence. To determine why aggregation was responsible for this phenomenon, the integrated stress response pathway was probed with salubrial and GSK-2606414. Treatment with salubrial had no significant effect, while GSK-2606414 mitigated the effects of aggregation leading to in vitro aging. This method holds the potential to increase the clinical relevance of MSC therapeutic effects from small model systems (such as rats and mice) to humans, and may open the potential of patient-derived MSCs for treatment thereby removing the need for immunosuppression.
The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure
Authors: Bahl Martin Iain , Honoré Anabelle Legarth , Skønager Sanne Tygesen , Honoré Oliver Legarth , Clausen Tove , Andresen Lars , Hammer Anne Sofie
Published: November 2020

On many mink farms, antibiotics are used extensively during the lactation period to reduce the prevalence and severity of pre-weaning diarrhoea (PWD) in mink kits (also referred to as greasy kit syndrome). Concerns have been raised, that routine treatment of PWD with antibiotics could affect the natural successional development of the gut microbiota, which may have long lasting consequences. Here we investigated the effects of early life antibiotic treatment administered for 1 week (postnatal days 13–20). Two routes of antibiotic administration were compared to a non-treated control group (CTR, n = 24). Routes of administration included indirect treatment, through the milk from dams receiving antibiotics by intramuscular administration (ABX_D, n = 24) and direct treatment by intramuscular administration to the kits (ABX_K, n = 24). A tendency for slightly increased weight at termination (Day 205) was observed in the ABX_K group. The gut microbiota composition was profiled by 16S rRNA gene sequencing at eight time points between Day 7 and Day 205. A clear successional development of the gut microbiota composition was observed and both treatment regimens caused detectable changes in the gut microbiota until at least eight days after treatment ceased. At termination, a significant positive correlation was identified between microbial diversity and animal weight.
Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
Authors: Rostami S. , Hoff M. , Dalen H. , Hveem K. , Videm V.
Published: November 2020

Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a population-based setting. Data from the prospective Nord-Trøndelag Health Study (HUNT2: 1995–1997 and HUNT3: 2006–2008) were used. wGRS added each participant’s carriage of all risk variants weighted by the coefficient from published association studies. Published wGRS for CAD and RA were analysed in Cox regression with MI as outcome, age as analysis time, and censoring at the first MI, death, or 31.12.2017. 2609 of 61,465 participants developed MI during follow-up (mean 17.7 years). The best-fitting wGRS for CAD and RA included 157 and 27 single-nucleotide polymorphisms, respectively. In multivariable analysis including traditional CAD risk factors, the CAD wGRS was associated with MI [hazard ratio = 1.23 (95% CI 1.18–1.27) for each SD increase, p < 0.0001] in RA patients (n = 433) and controls. The RA wGRS was not significant (p = 0.06). Independently from traditional risk factors, a CAD wGRS was significantly associated with the risk for MI in RA patients and controls, whereas an RA wGRS was not. The captured genetic risk for RA contributed little to the risk of MI.
Complex fibroblast response to glucocorticoids may underlie variability of clinical efficacy in the vocal folds
Authors: Nakamura Ryosuke , Mukudai Shigeyuki , Bing Renjie , Garabedian Michael J. , Branski Ryan C.
Published: November 2020

Similar to the hypertrophic scar and keloids, the efficacy of glucorticoids (GC) for vocal fold injury is highly variable. We previously reported dexamethasone enhanced the pro-fibrotic effects of transforming growth factor (TGF)-β as a potential mechanism for inconsistent clinical outcomes. In the current study, we sought to determine the mechanism(s) whereby GCs influence the fibrotic response and mechanisms underlying these effects with an emphasis on TGF-β and nuclear receptor subfamily 4 group A member 1 (NR4A1) signaling. Human VF fibroblasts (HVOX) were treated with three commonly-employed GCs+ /-TGF-β1. Phosphorylation of the glucocorticoid receptor (GR:NR3C1) and activation of NR4A1 was analyzed by western blotting. Genes involved in the fibrotic response, including ACTA2, TGFBR1, and TGFBR2 were analyzed by qPCR. RNA-seq was performed to identify global changes in gene expression induced by dexamethasone. GCs enhanced phosphorylation of GR at Ser211 and TGF-β-induced ACTA2 expression. Dexamethasone upregulated TGFBR1, and TGFBR2 in the presence of TGF-β1 and increased active NR4A1. RNA-seq results confirmed numerous pathways, including TGF-β signaling, affected by dexamethasone. Synergistic pro-fibrotic effects of TGF-β were observed across GCs and appeared to be mediated, at least partially, via upregulation of TGF-β receptors. Dexamethasone exhibited diverse regulation of gene expression including NR4A1 upregulation consistent with the anti-fibrotic potential of GCs.
The electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots
Authors: Arshad Humaira , Chaudhry Madeeha , Mehmood Shahid , Farooq Ayesha , Wang Minqiang , Bhatti A. S.
Published: November 2020

This paper reports the enhanced performance of cholesterol oxidase (COx) conjugated CdSe/ZnS quantum dots (QDs) by using water-soluble mercaptoacitic acid (MAA) as linker. The functionalized MAA-CdSe/ZnS QDs conjugated in four different dilutions of cholesterol oxidase significantly affected QDs photoluminescence intensities, which affected the process of charge transfer from QDs to MAA. The conjugation of COx to MAA-QDs in increased dilutions resulted in the regain of PL intensities, which were attributed to the passivation of MAA HOMO/LUMO states. The electrochemical impedance spectroscopy and cyclic voltammetry of the conjugated QDs were performed to get study the charge transfer mechanism. The 1:1000 diluted COx conjugated MAA-CdSe/ZnS QDs was found to have the lowest charge transfer resistance of 228 Ω, the highest diffusion (~ 1.39 × 10–13cm2/s) and charge transfer rates (~ 4.5 × 10–6 s−1) between the electrode and the redox species. The current study demonstrated the sensitivity of electrochemical and optical based detection on the alkaline.
Time-course profiling of bovine alphaherpesvirus 1.1 transcriptome using multiplatform sequencing
Authors: Moldován Norbert , Torma Gábor , Gulyás Gábor , Hornyák Ákos , Zádori Zoltán , Jefferson Victoria A. , Csabai Zsolt , Boldogkői Miklós , Tombácz Dóra , Meyer Florencia , Boldogkői Zsolt
Published: November 2020

Long-read sequencing (LRS) has become a standard approach for transcriptome analysis in recent years. Bovine alphaherpesvirus 1 (BoHV-1) is an important pathogen of cattle worldwide. This study reports the profiling of the dynamic lytic transcriptome of BoHV-1 using two long-read sequencing (LRS) techniques, the Oxford Nanopore Technologies MinION, and the LoopSeq synthetic LRS methods, using multiple library preparation protocols. In this work, we annotated viral mRNAs and non-coding transcripts, and a large number of transcript isoforms, including transcription start and end sites, as well as splice variants of BoHV-1. Our analysis demonstrated an extremely complex pattern of transcriptional overlaps.
Reproductive inhibition among nestmate queens in the invasive Argentine ant
Authors: Abril Sílvia , Gómez Crisanto
Published: November 2020

In social species, the presence of several reproductive individuals can generate conflict. In social insects, as queen number increases, individual oviposition rate may decrease because of direct and indirect behavioural and/or chemical interactions. Understanding the factors that mediate differences in queen fecundity should provide insight into the regulation and maintenance of highly polygynous insect societies, such as those of the invasive Argentine ant (Linepithema humile). In this study, we investigated (1) whether differences in the oviposition rates of Argentine ant queens exposed to polygynous conditions could result from interactions among them; (2) whether such differences in fecundity stemmed from differences in worker attention; and (3) whether polygynous conditions affected the cuticular hydrocarbon profiles of queens (CHCs). We found that differences in queen fecundity and CHC profiles observed under polygynous conditions disappeared when queens were exposed to monogynous conditions, suggesting some form of reproductive inhibition may exist when queens cohabit. These differences did not seem to arise from variation in worker attention because more fecund queens were not more attractive to workers. Levels of some CHCs were higher in more fecund queens. These CHCs are associated with greater queen productivity and survival. Our findings indicate that such compounds could be multifunctional queen pheromones.
An integrative atlas of chicken long non-coding genes and their annotations across 25 tissues
Authors: Jehl Frédéric , Muret Kévin , Bernard Maria , Boutin Morgane , Lagoutte Laetitia , Désert Colette , Dehais Patrice , Esquerré Diane , Acloque Hervé , Giuffra Elisabetta , Djebali Sarah , Foissac Sylvain , Derrien Thomas , Pitel Frédérique , Zerjal Tatiana , Klopp Christophe , Lagarrigue Sandrine
Published: November 2020

Long non-coding RNAs (LNC) regulate numerous biological processes. In contrast to human, the identification of LNC in farm species, like chicken, is still lacunar. We propose a catalogue of 52,075 chicken genes enriched in LNC (http://www.fragencode.org/), built from the Ensembl reference extended using novel LNC modelled here from 364 RNA-seq and LNC from four public databases. The Ensembl reference grew from 4,643 to 30,084 LNC, of which 59% and 41% with expression ≥ 0.5 and ≥ 1 TPM respectively. Characterization of these LNC relatively to the closest protein coding genes (PCG) revealed that 79% of LNC are in intergenic regions, as in other species. Expression analysis across 25 tissues revealed an enrichment of co-expressed LNC:PCG pairs, suggesting co-regulation and/or co-function. As expected LNC were more tissue-specific than PCG (25% vs. 10%). Similarly to human, 16% of chicken LNC hosted one or more miRNA. We highlighted a new chicken LNC, hosting miR155, conserved in human, highly expressed in immune tissues like miR155, and correlated with immunity-related PCG in both species. Among LNC:PCG pairs tissue-specific in the same tissue, we revealed an enrichment of divergent pairs with the PCG coding transcription factors, as for example LHX5, HXD3 and TBX4, in both human and chicken.
Modulation of granulosa cell function via CRISPR-Cas fuelled editing of BMPR-IB gene in goats (Capra hircus)
Authors: Kumar Sai , Punetha Meeti , Jose Bosco , Bharati Jaya , Khanna Shivani , Sonwane Arvind , Green Jonathan A. , Whitworth Kristin , Sarkar Mihir
Published: November 2020

BMPs are multifunctional growth factors implicated in regulating the ovarian function as key intra-ovarian factors. Biological effects of BMPs are mediated through binding with membrane bound receptors like BMPR-IB and initiating downstream Smad signaling pathway. FecB mutation, regarded as a loss of function mutation in the BMPR-IB gene was identified in certain sheep breeds having high fecundity. Similar type of fecundity genes in goats have not been discovered so far. Hence, the current study was designed to investigate the effects of BMPR-IB gene modulation on granulosa cell function in goats. The BMPR-IB gene was knocked out using CRISPR-Cas technology in granulosa cells and cultured in vitro with BMP-4 stimulation for three different durations In addition, the FecB mutation was introduced in the BMPR-IB gene applying Easi-CRISPR followed by BMP-4/7 stimulation for 72 h. Steroidogenesis and cell viability were studied to explore the granulosa cell function on BMPR-IB gene modulation. BMPRs were found to be expressed stage specifically in granulosa cells of goats. Higher transcriptional abundance of R-Smads, LHR and FSHR indicating sensitisation of Smad signaling and increased gonadotropin sensitivity along with a significant reduction in the cell proliferation and viability was observed in granulosa cells upon BMPR-IB modulation. The inhibitory action of BMP-4/7 on P4 secretion was abolished in both KO and KI cells. Altogether, the study has revealed an altered Smad signaling, steroidogenesis and cell viability upon modulation of BMPR-IB gene in granulosa cells similar to that are documented in sheep breeds carrying the FecB mutation.
Trisulfide linked cholesteryl PEG conjugate attenuates intracellular ROS and collagen-1 production in a breast cancer co-culture model
Authors: Dao Nam V. , Ercole Francesca , Urquhart Matthew C. , Kaminskas Lisa M. , Nowell Cameron J. , Davis Thomas P. , Sloan Erica K. , Whittaker Michael R. , Quinn John F.
Published: November 2020

Treatment of cancer cell-fibroblast co-cultures with H2S-releasing trisulfide conjugate causes restoration of ROS levels in the cancer cells and normalisation of collagen-1 expression in the fibroblasts.
In situanodic dissolution–cathodic deposition route for preparation of the Pt–SiW11Co/SiW11Co–CNP/GC electrode: application as an efficient electrode for the hydrogen evolution reaction
Authors: Hashemniaye-Torshizi Reihaneh , Ashraf Narges , Arbab-Zavar Mohammad Hossein , Dianat Somayeh
Published: November 2020

A novel nanohybrid based on carbon nanoparticles, platinum nanoparticles, and SiW11Co polyoxometalate is introduced as an efficient electrocatalyst for the hydrogen evolution reaction (HER).
Surface oxygen species essential for the catalytic activity of Ce–M–Sn (M = Mn or Fe) in soot oxidation
Authors: Wang Meng , Zhang Yan , Yu Yunbo , Shan Wenpo , He Hong
Published: November 2020

Herein, transition metal (Mn and Fe)-doped Ce–Sn nanorod catalysts were successfully synthesized via a hydrothermal method.
Semiconducting properties of pyridyl appended linear dicarboxylate based coordination polymers: theoretical predictionviaDFT study
Authors: Ahmed Faruk , Ortega-Castro Joaquín , Frontera Antonio , Mir Mohammad Hedayetullah
Published: November 2020

This work highlights the theoretical elucidation of semiconducting properties and a probable pathway for the optimum charge transportation in coordination polymers.
Low-dose alcohol ameliorated high fat diet-induced anxiety-related behavior via enhancing adiponectin expression and activating the Nrf2 pathway
Authors: Cheng Jie , Zhang Meng , Cheng Shaoli , Li Fan , Zhang Bingyi , Sun Xiaoming , Hu Huijuan , Chen Lina , Zhao Zhenghang , Hu Hao , Zhang Zhanqin
Published: November 2020

Low-dose alcohol protected HFD-induced obese mice from the augmentation of anxiety-related behavior, which might be related to APN upregulation and Nrf2 activation.
Correction: Overview of sterilization methods for UHMWPE through surface analysis
Authors: Rodrigues Melissa Machado , Kerstner Baldin Estela K. , Fontoura Cristian Padilha , Leidens Leonardo Mathias , Barbieri Rodrigo Antônio , Frassini Rafaele , de Fraga Malfatti Célia , Roesch-Ely Mariana , Figueroa Carlos Alejandro , Aguzzoli Cesar
Published: November 2020

Correction for ‘Overview of sterilization methods for UHMWPE through surface analysis’ by Melissa Machado Rodrigues et al., Mater. Adv., 2020, DOI: 10.1039/d0ma00772b.
Unveiling the mechanism of structure-dependent thermal transport behavior in self-folded graphene film: a multiscale study
Authors: Wei Anran , Ye Han , Gao Yang , Guo Fenglin
Published: November 2020

A theoretical model is developed to demonstrate the relationship between the fold length and thermal transport behavior in self-folded graphene film, validated by molecular dynamics simulations. The effect of tension is also revealed by this model.
Low temperature selective catalytic reduction of nitric oxide with an activated carbon-supported zero-valent iron catalyst
Authors: Cao Wan , Zhang Weijun
Published: November 2020

A novel transition metal-supported catalyst which can be used for denitrification in a low-temperature sintering flue gas.
Enhancing thermal conductivity of polyimide composite film by electrostatic self-assembly and two-step synergism of Al2O3 microspheres and BN nanosheets
Authors: Liu Dongxu , Ma Chuanguo , Chi Hongtao , Li Shihui , Zhang Ping , Dai Peibang
Published: November 2020

A strategy of electrostatic self-assembly and two-step synergism was proposed to significantly improve the thermal conductivity of the PI composite film.
A mechanistic investigation of low salinity water flooding coupled with ion tuning for enhanced oil recovery
Authors: Saw Rohit Kumar , Mandal Ajay
Published: November 2020

The combined effects of dilution and ion tuning of seawater for enhanced oil recovery from carbonate reservoirs. Dominating mechanisms are calcite dissolution and the interplay of potential determining ions that lead to wettability alteration of rock surface.
Catalytic coproduction of methanol and glycol in one pot from epoxide, CO2, and H2
Authors: Kothandaraman Jotheeswari , Heldebrant David J.
Published: November 2020

An atom (100%) and energy-efficient approach to coproduce two commodity chemicals, methanol and glycol, has been demonstrated for the first time using H2, CO2, and epoxide as feeds.
Effect of precise linker length, bond density, and broad temperature window on the rheological properties of ethylene vitrimers
Authors: Soman Bhaskar , Evans Christopher M.
Published: November 2020

Dynamic networks with precise spacers between boronic ester bonds were investigated over a broad temperature window. Arrhenius behavior breaks down and an increase in relaxation time is observed when approach the glass transition temperature.
Chemical supercapacitors: a review focusing on metallic compounds and conducting polymers
Authors: Naskar Pappu , Maiti Apurba , Chakraborty Priyanka , Kundu Debojyoti , Biswas Biplab , Banerjee Anjan
Published: November 2020

Material-bank for chemical supercapacitors.
The ROSAT Raster survey in the north ecliptic pole field
Authors: Hasinger G. , Freyberg M. , Hu E. M. , Waters C. Z. , Capak P. , Moneti A. , McCracken H. J.
Published: November 2020

The north ecliptic pole (NEP) is an important region for extragalactic surveys. Deep and wide contiguous surveys are being performed by several space observatories, most currently with the eROSITA telescope. Several more are planned for the near future. We analyse all the ROSAT pointed and survey observations in a region of 40 deg2 around the NEP, restricting the ROSAT field of view to the inner 30′ radius. We obtain an X-ray catalogue of 805 sources with 0.5−2 keV fluxes > 2.9 × 10−15 erg cm−2 s−1, about a factor of three deeper than the ROSAT All-Sky Survey in this field. The sensitivity and angular resolution of our data are comparable to the eROSITA All-Sky Survey expectations. The 50% position error radius of the sample of X-ray sources is ∼10″. We use HEROES optical and near-infrared imaging photometry from the Subaru and Canada/France/Hawaii telescopes together with GALEX, SDSS, Pan-STARRS, and WISE catalogues, as well as images from a new deep and wide Spitzer survey in the field to statistically identify the X-ray sources and to calculate photometric redshifts for the candidate counterparts. In particular, we utilize mid-infrared (mid-IR) colours to identify active galactic nucleus (AGN) X-ray counterparts. Despite the relatively large error circles and often faint counterparts, together with confusion issues and systematic errors, we obtain a rather reliable catalogue of 766 high-quality optical counterparts, corresponding redshifts and optical classifications. The quality of the dataset is sufficient to look at ensemble properties of X-ray source classes. In particular we find a new population of luminous absorbed X-ray AGN at large redshifts, identified through their mid-IR colours. This populous group of AGN was not recognized in previous X-ray surveys, but could be identified in our work due to the unique combination of survey solid angle, X-ray sensitivity, and quality of the multi-wavelength photometry. We also use the WISE and Spitzer photometry to identify a sample of 185 AGN selected purely through their mid-IR colours, most of which are not detected by ROSAT. Their redshifts and upper limits to X-ray luminosity and X-ray–to–optical flux ratios are even higher than for the new class of X-ray selected luminous type 2 AGN (AGN2); they are probably a natural extension of this sample. This unique dataset is important as a reference sample for future deep surveys in the NEP region, in particular for eROSITA and also for Euclid and SPHEREX. We predict that most of the absorbed distant AGN should be readily picked up by eROSITA, but they require sensitive mid-IR imaging to be recognized as optical counterparts.
Poly-phased fluid flow in the giant fossil pockmark of Beauvoisin, SE basin of France
Authors: Gay Aurélien , Favier Alexiane , Potdevin Jean-Luc , Lopez Michel , Bosch Delphine , Tribovillard Nicolas , Ventalon Sandra , Cavailhes Thibault , Neumaier Martin , Revillon Sidonie , Travé Anna , Bruguier Olivier , Delmas Doriane , Nevado Christophe
Published: November 2020

The giant Jurassic-aged pockmark field of Beauvoisin developed in a 800 m wide depression for over 3.4 Ma during the Oxfordian; it formed below about 600 m water depth. It is composed of sub-sites organized in clusters and forming vertically stacked carbonate lenses encased in marls . This fine-scale study is focused on a detailed analysis of petrographical organization and geochemical signatures of crystals that grew up in early to late fractures of carbonate lenses, surrounding nodules, and tubes that fed them. The isotopic signature (C, O and Sr) shows that at least three different episodes of fluid migration participated to the mineralization processes. Most of the carbonates precipitated when biogenic seepage was active in the shallow subsurface during the Oxfordian. The second phase occurred relatively soon after burial during early Cretaceous and thermogenic fluids came probably from underlying Pliensbachian, Late Toarcian or Bajocian levels. The third phase is a bitumen-rich fluid probably related to these levels reaching the oil window during Mio-Pliocene. The fluids migrated through faults induced by the emplacement of Triassic-salt diapir of Propiac during the Late Jurassic and that remained polyphased drain structures over time.
Crises environnementales et sanitaires : des maladies de l’anthropocène qui appellent à refonder notre système alimentaire
Authors: Duru Michel , Le Bras Claire
Published: November 2020

Depuis le milieu du XXe siècle, les impacts des activités humaines sur les écosystèmes sont croissants. À l’érosion de la biodiversité et au dérèglement climatique, ainsi qu’au développement de maladies chroniques que constituent l’obésité et le diabète, s’ajoute désormais la pandémie du coronavirus. Il s’agit d’un ensemble de crises environnementales ou sanitaires qui résultent pour partie de facteurs communs et dont les impacts peuvent se conjuguer et s’amplifier. Dans ce contexte inédit, nos modes de production, transformation, distribution et consommation des aliments sont particulièrement interrogés. Ils sont à l’origine d’une part importante des émissions de gaz à effet de serre, participent à la destruction de certains habitats naturels réservoirs d’agents pathogènes et contribuent à l’émergence de maladies chroniques chez l’homme. De ce fait, la nécessité d’une transition de notre système alimentaire est une idée qui fait consensus, même si le choix des changements à opérer concrètement pose de nombreuses questions. À travers une approche systémique de « santé globale », rendant compte de l’interdépendance de l’état de santé de l’Homme, des animaux et des écosystèmes dans lesquels ils évoluent, nous montrons qu’il faut prioriser aussi bien les enjeux environnementaux que de santé pour mener à bien ces arbitrages. Nous montrons qu’il est possible de faire des choix doublement vertueux pour l’environnement et la santé en transformant les modes de production, de transformation, de distribution et de consommation des aliments : réorienter l’élevage, abaisser le degré de transformation des aliments, diversifier les modes de distribution et « végétaliser » notre assiette. Ces changements participent à la territorialisation du système alimentaire.
Development of agricultural activities in Russia and the Sverdlovsk region in terms of environmental instability
Authors: Aleksandrovich Voronin Boris , Pavlovna Chupina Irina , Viktorovna Voronina Yana , Vasilievna Zarubina Elena
Published: November 2020

The model or way of development of the village and rural economy is always associated with the state policy in relation to the rural areas. Since rural areas are not only a place of residence for human capital, but also a place of labor and economic activity of the rural residents, who are initially employed in agriculture, it is natural that the existing agricultural policy has a huge impact on the model or way of the rural development. The model of the existence of the economic entities in the rural areas under the conditions of exclusive state land ownership has ended since 1990. From here, in the 21st century, the formation of a modern model of Russian agriculture began with organizational and legal forms of management inherent in a market economy.
Raw material safety as one of the factors of sustainable development of the food industry
Authors: Arisov Aleksandr , Leyvy Artem , Kryukova Ekaterina , Zavorokhina Natalia , Pastushkova Ekaterina
Published: November 2020

One of the trends in the development of the public catering market in the Ural region is the emergence of new “players”, which leads to increased competition. The use of crushed sprouted grain in public catering products can increase the competitiveness of enterprises, because in the field of public catering, the trend towards healthy eating continues, one of the directions of which is grain germination. The seeds germinate in a humid environment. They have a high content of carbohydrates (in particular starch) and are not always under the lights, which contributes to the reproduction of microorganisms. To suppress the growth of the number of microorganisms, it is proposed to use cold plasma radiation. Such a non-thermal physical effect will reduce the microbiological parameters of raw materials without affecting the physical and chemical processes during germination of the sprout. The optimal value of settings at which the required level of microbiological contamination is achieved has been determined. With increasing exposure, microbiological parameters change slightly, while the cost of processing increases.
Environmental security as a factor of sustainable development of the territory
Authors: Anasenko E.V. , Zholudeva V.V. , Melnichenko N.F.
Published: November 2020

The article deals with the issues of environmental security within the concept of sustainable development. The authors analyzed various approaches to the definition of sustainable development and developed their own position on this term. Environmental security is closely related to sustainable development. The article analyzes the ecological situation in Moscow and draws conclusions based on statistical material. Also, the main factors influencing the ecological situation of the territory were identified and studied on the example of Moscow. The study, involved a correlation-regression analysis to determine the influence of the degree of environmental pollution on demographic aspects, during which a moderate relationship was established between the mortality rate of the population, life expectancy, and factor signs associated with the environmental influence. The research results proved the need to ensure its environmental security to achieve the goals of sustainable development of any territory. And the creation of conditions for a comfortable life of the current generations, the satisfaction of their ever-increasing needs without prejudice to future generations is possible only with a competent prioritization in the state policy of any country, first of all, solving environmental problems.
Statistical analysis of the driving forces of anthropogenic impact on the environment
Authors: Prokopyev Mikhail G. , Vitukhin Anton D.
Published: November 2020

The aim of the study is to analyze the driving forces of the impact of human activities on the environment. The problem of assessing the influence of the population size, the level of economic development, as well as the technological factor on the volume of emissions of pollutants into the atmospheric air in the regions of the Russian Federation is considered. A retrospective of models for analyzing the main driving forces of anthropogenic impact on the environment is presented. The study is based on the STIRPAT model. The results of the econometric assessment showed that both the population and the level of economic development (GRP per capita) have a decisive influence on the increase in air emissions in the regions of the Russian Federation. A decrease in the energy intensity of GRP, as well as the share of manufacturing and extractive industries in the sectoral structure of GRP, also leads to a significant decrease in the environmental load. However, the values of the corresponding environmental elasticities are significantly lower than the elasticities of emissions of pollutants into the atmosphere with changes in population size and economic growth (GRP per capita).
Equations of temperature graphics of a heating point with a two-stage scheme of heat exchangers of hot water supply
Authors: Rafalskaya Tatyana
Published: November 2020

The temperature of the water returned to the heating network from consumers largely determines the energy efficiency of the heat supply system. It depends on a number of parameters: outside air temperature, hot water supply heaters connection scheme, daily water consumption in the hot water supply system. The calculation of this temperature is usually performed numerically, which makes it difficult to control the modes of the heat supply system. From a practical point of view, a simpler toolkit is needed. In this paper, equations are proposed that allow directly determining the change in the heat output of heat exchangers depending on the outside air temperature and the temperature of the network water returned to the heating network. These equations are obtained on the basis of systematic modeling of variable operating modes of the heat supply system, using the method previously proposed by the author. The operating characteristics of the heat station are taken into account by the coefficients of the equations, for the determination of which the calculation formulas were obtained. The equations used are valid for substations with a two-stage mixed scheme of hot water supply heaters in the mode of maximum water consumption.
On energy constraints on housing development
Authors: Pestryakov Aleksey , Sbrodova Nadezhda , Albycheva Mariya
Published: November 2020

The article examines the dependence of the “smart home” technology on the technical capabilities of the engineering infrastructure. Home automation ideas have been evolving since the early 20th century. However, this technology is not widespread yet due to a number of features of the system. We consider the dependence of the reliability of the system on the characteristics of external power grids. There are technological developments in housing construction sphere that make it possible to maximize the satisfaction of the needs of residents. At the same time, the irrational distribution of capacities, the unpredictability (for operating organizations) of territorial development plans, and increased consumer demands hinder the use of modern technologies.
Development of indicators for assessing the university development potential in solving management problems
Authors: Petrova Tatyana , Bobko Tatyana , Kazantseva Galina , Zatepyakin Oleg
Published: November 2020

. The research devoted to a comprehensive study of market factors, that affect the improvement of HEIs efficiency and the possibility of solving the problems of universities management, is important for the practical implementation of the fundamental principles of enhancing the Russian universities competitiveness. Such studies are of particular importance in relation to regional universities, which are in difficult conditions: they need to strive for global competitiveness and meet the local territories requirements. The objects of the external environment having connections with universities are identified. Their internal potentials can influence the future university resulting indicators. The originality of this work lies in the proposed system of indicators for solving the problems of university management based on its development potential assessment, taking into account the influence of the external environment potentials of the personnel training market. These indicators have not been sufficiently reflected in the methodology for monitoring the efficiency improvement of universities’ activities, developed and implemented by the Ministry of Science and Higher Education of the Russian Federation. The study results can serve as an information and analytical basis for making management decisions in the field of organizing university scientific and educational activities, taking into account its promising development potential.
The systemic paradigm of the modernization of the Russian energy for the purpose of sustainable development
Authors: Krasilnikova Elena , Nikonova Alla
Published: November 2020

Keeping in mind the significant dependence of the Russian economy on oil and gas revenues coupled with the low energy efficiency and technology backwardness, the country faces noticeable threats to its technological and economic sustainable development. Findings of a system analysis of the Russian energy sector indicate the need for organizational and technological changes. It is found that easily available opportunities to get raw material rent, along with respective rules of the game, reduce economic agents’ interest to innovations. External risks, such as sanctions, volatile energy markets, are not the root cause of the crisis in Russia, but these factors do destabilize the situation and make modernization more difficult. In this context, strategies and mechanisms that meet internal and external challenges are required. The novelty of the approach is that the improved systemic economic paradigm of innovation strategy formulation and support mechanisms implies moving the development drivers from the category of external impacts on the country’s energy sector to the category of internal imperatives of its technological development through creation and stimulation of innovation and industrial ecosystems where the energy sector will serve as an infrastructure framework that consolidates all sectors of the economy.
Banking operations development in the context of stable interbank competition
Authors: Nasyrova Gulmira , Yuzvovich Larisa , Knyazeva Elena , Isakova Natalia
Published: November 2020

A stable banking sector is important for any economy due to its colossal impact on both economic processes in the country and the life of society as a whole. Among the significant trends in the development of the banking sector for 2020, experts highlighted a significant reduction in the number of banks, an increase in the concentration of assets in the sector, the acquisition of IT companies by large banks and a reduction in the time spent on developing and launching new products, the development of biometrics and gamification of loyalty programs, strengthening of positions the largest credit institutions and an increase in the share of banks with government support. Let us emphasize that modern banks are entering the field of competition with large technological and financial-technological corporations. They are forced to increase the availability, mobility, convenience and speed of service provision, to optimize costs by transforming the branch network, developing remote channels and analytics in terms of consumer preferences, which allows them to offer customers the most customized set of services. The subject of the research is the economic relations arising in the process of organizing banking operations in the context of interbank competition.
Sustainable development in the face of new strategic challenges
Authors: Ilyukhin Alexey , Ponomareva Svetlana , Ilyukhina Svetlana
Published: November 2020

The study attempts to assess the economic potential of a large industrial region, the Sverdlovsk Region, as the basis for sustainable development in the new economic realities generated by the global pandemic of 2020 associated with the COVID-19 threats. As a hypothesis of the study, the assumption is considered that the sustainable development of the regional economy in the new conditions is ensured by the accumulated economic potential in the context of the coronary crisis trigger of contradictions. The aim of the study is to study and assess the economic potential of the Sverdlovsk region, the dynamics of its development in the face of new strategic challenges. To assess and predict the economic potential that ensures the sustainable development of the region in the context of the coronavirus-related trigger of contradictions, a study was carried out of relevant scientific publications by leading scientists in this field for 2019-20. The economic potential of the Sverdlovsk region was determined, calculated on the basis of a mathematical model, using statistical data on the following indicators: gross regional product per capita in thousand rubles; average life expectancy of the population in the region; the number of hospital beds and schools per 10 thousand population; the percentage of innovative products in the total volume of the region. Based on the data obtained, an econometric model according to Altman was developed to analyze and forecast the economic potential of the Sverdlovsk region. The calculated, accumulated economic potential undoubtedly provides opportunities for sustainable development even in the face of coronary crisis challenges of the economy. At the same time, it is very important to ensure an increase in the long-term structural rates of economic growth.
Economic effectiveness of the organization’s economic activities
Authors: Chepulaynis Anton , Boronenkova Svetlana
Published: November 2020

The article examines the theoretical aspects of the economic effectiveness of the organization’s economic activity, presents the author’s definition of the concept. To reveal the essence of economic effectiveness, a systematization and classification of types of effectiveness are given. For each type of effectiveness, specific desired ratios and growth indicators (drivers) are indicated, which ensures the continuity and sustainable development of the business in the future.
Development of financial intermediation in a sustainable economy
Authors: Mikryukov Aleksey , Serebrennikova Anna
Published: November 2020

The article examines the theoretical and practical aspects of the development of financial intermediation in the context of sustainable economic development. Sustainable economic development has an impact on the life of the population and enterprises and leads to changes in their needs. Meeting the needs of the entire society is possible through the sustainable development of the financial market as a whole and its individual segments, including new areas of financial intermediation. Banks are considered one of the first financial intermediaries, but the steady development of the economy, accompanied by digitalization, leads to the emergence of new, alternative directions. One of them is crowdfunding. For credit institutions, crowdfunding is an opportunity to diversify their business, reduce lending risks, and expand their customer base. The article presents the dynamics of crowdfunding development in the Russian Federation and presents a comparative analysis of the main financial indicators of the largest Russian banks and crowdfunding platforms.The conclusion is made about the role of banks and alternative financing methods in a sustainable economy and their positive impact on the development of the real sector of the economy.
Sustainable development of organizations in modern conditions
Authors: Prostova Dina , Sosnina Natalya , Tikhonova Anna
Published: November 2020

The article studies with the theoretical issues of sustainable development of organizations in modern conditions. The authors show that through achieving efficiency and effectiveness, an organization can thus ensure its sustainable development, and also provide a model of “4K ensuring the sustainable development of market entities”. Logical, expert, and system analysis were used as research methods. The specifics of the problem of determining the factors that affect the ability of economic entities to form a sustainable development strategy in modern conditions determined the structure of the study. The authors analyze various interpretations of the term “sustainability” and present the main factors affecting the development of economic systems in the form of a model of the organization’s functioning, taking into account the influence of environmental factors. In conclusion, the article substantiates the following: the presented model proves that to meet the needs of their stakeholders, organizations need to have certain capabilities, the effectiveness of which they can achieve by improving their management system.
Transformative Investments in Sustainable Economic Development: Infrastructure Aspect
Authors: Dvoryadkina Elena , Kvon Gulnara , Pozdeeva Olga
Published: November 2020

The article is devoted to the study of the role of infrastructure in the sustainable development of the economy, the investment of which makes it possible to ensure the achievement of social and environmental results along with economic ones. This type of investment has great potential in solving global problems of mankind, providing a positive impact on the economies of various countries. Mobilizing investment in infrastructure that catalyzes the improvement of environmental, social and political processes in economic systems stimulates the development of industries and often must precede this. The relevance of transformative investments is growing in the face of a lack of resources of governments of various states to address the priority problems of overcoming poverty, social inequality and reducing social tensions in this regard. Despite the fact that transformative investment is a relatively new topic, which is reflected in various discussions at the global level, the implementation of this form of investment to achieve the UN sustainable development goals in order to ensure a decent standard and quality of life for the population contributes to the creation of favorable conditions for interaction between countries.
Economic sustainability in the era of complex technological systems: a fresh approach
Authors: Orekhova Svetlana , Evseeva Marina
Published: November 2020

The article presents a view on the structure and stability of the economic system through the prism of interconnected technologies. Based on the genesis of the term “technology”, as well as methodological provisions of the theory of complexity and neo-institutional economic theory, the concept of “technological system” as a special mechanism for coordination is introduced. Technology is considered as a system of interspecific resources and institutions. The boundaries of technological systems are defined by a bundle of interrelated technologies that function continuously through the implementation of self-executing institutional agreements. Four distinguished types of technological systems differ in the distribution of the bundle of property rights and the level of centralization.It is shown that the introduction of the concept of “technological systems” into scientific circulation will expand the understanding of mechanisms ensuring sustainable economic growth.
Impact of Depreciation Deduction Calculation Method on Financial Soundness Improvement of Economic Agents
Authors: Mishin Yurii V. , Mishin Aleksandr Yu.
Published: November 2020

The purpose of this paper is to prepare suggestions on the use of capital depreciation methods as the key tool of industrial enterprise and organization financial soundness improvement that provides the gained profit increase, and thus the capital position.The paper solves the following issues: 1) In the result of comparative analysis of specific features, advantages and disadvantages of depreciation accrual methods, indices of average annual manufacturing capacity actual employment in the context of the most important types of output industrial products it was concluded that the majority of such methods (except the method for depreciation accrual in proportion to the gross output) doesn’t consider the actual load of process equipment; 2) the methodological approach to modification of average annual manufacturing capacity actual employment was substantiated by introducing the calculation formula and the coefficient of average annual manufacturing capacity actual employment; 3) calculations on annual 2016 and 2017 returns were carried out for several economic activities in order to assess product cost reduction (growth of profits) due to the proposed methodological approach.
Management principles and their application as a strategic guideline for sustainable business development
Authors: Popova Elena , Bazelyuk Vladimir , Demina Nadezhda , Demin Alexander , Letaeva Tatiana
Published: November 2020

The fundamental principles of management, as well as the practice of their application in industrial production sphere are described in the article in detail. The author gives an idea of the managerial principles evolution in an enterprise-type organization (both in our country and abroad). Special attention is paid to the managerial culture formation theory and its influence on the entrepreneurial and strategic management combination . The main idea of the presented work is an evolutionary approach to effective management principles classification in relation to business activities carried out within self-organizing micro-level systems. Their developmental gene, as shown in the work, is the management culture, its formation is the subject of this study. The study research area is management science issues and its cognition methods development: developmental factors and managerial principles of an enterprise-type organization.