bluuebunny/crossref_metadata_2025 huggingface dataset:
The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor–Mediated Cross-Linking
Authors: Overdijk Marije B. , Jansen J. H. Marco , Nederend Maaike , Lammerts van Bueren Jeroen J. , Groen Richard W. J. , Parren Paul W. H. I. , Leusen Jeanette H. W. , Boross Peter
Published: June 2016

Emerging evidence suggests that FcγR-mediated cross-linking of tumor-bound mAbs may induce signaling in tumor cells that contributes to their therapeutic activity. In this study, we show that daratumumab (DARA), a therapeutic human CD38 mAb with a broad-spectrum killing activity, is able to induce programmed cell death (PCD) of CD38+ multiple myeloma tumor cell lines when cross-linked in vitro by secondary Abs or via an FcγR. By comparing DARA efficacy in a syngeneic in vivo tumor model using FcRγ-chain knockout or NOTAM mice carrying a signaling-inactive FcRγ-chain, we found that the inhibitory FcγRIIb as well as activating FcγRs induce DARA cross-linking–mediated PCD. In conclusion, our in vitro and in vivo data show that FcγR-mediated cross-linking of DARA induces PCD of CD38-expressing multiple myeloma tumor cells, which potentially contributes to the depth of response observed in DARA-treated patients and the drug’s multifaceted mechanisms of action.
Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis
Authors: Su Pan , Chen Sheng , Zheng Yu Han , Zhou Hai Yan , Yan Cheng Hua , Yu Fang , Zhang Ya Guang , He Lan , Zhang Yuan , Wang Yanming , Wu Lei , Wu Xiaoai , Yu Bingke , Ma Li Yan , Yang Zhiru , Wang Jianhua , Zhao Guixian , Zhu Jinfang , Wu Zhi-Ying , Sun Bing
Published: June 2016

Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS characterized by demyelination and axonal damage. Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model for human MS. Although Th17 cells are important for disease induction, Th2 cells are inhibitory in this process. In this article, we report the effect of a Th2 cell product, extracellular matrix protein 1 (ECM1), on the differentiation of Th17 cells and the development of EAE. Our results demonstrated that ECM1 administration from day 1 to day 7 following the EAE induction could ameliorate the Th17 cell responses and EAE development in vivo. Further study of the mechanism revealed that ECM1 could interact with αv integrin on dendritic cells and block the αv integrin–mediated activation of latent TGF-β, resulting in an inhibition of Th17 cell differentiation at an early stage of EAE induction. Furthermore, overexpression of ECM1 in vivo significantly inhibited the Th17 cell response and EAE induction in ECM1 transgenic mice. Overall, our work has identified a novel function of ECM1 in inhibiting Th17 cell differentiation in the EAE model, suggesting that ECM1 may have the potential to be used in clinical applications for understanding the pathogenesis of MS and its diagnosis.
Mining Health-Related Issues in Consumer Product Reviews by Using Scalable Text Analytics
Authors: Torii Manabu , Tilak Sameer S. , Doan Son , Zisook Daniel S. , Fan Jung-wei
Published: June 2016

In an era when most of our life activities are digitized and recorded, opportunities abound to gain insights about population health. Online product reviews present a unique data source that is currently underexplored. Health-related information, although scarce, can be systematically mined in online product reviews. Leveraging natural language processing and machine learning tools, we were able to mine 1.3 million grocery product reviews for health-related information. The objectives of the study were as follows: (1) conduct quantitative and qualitative analysis on the types of health issues found in consumer product reviews; (2) develop a machine learning classifier to detect reviews that contain health-related issues; and (3) gain insights about the task characteristics and challenges for text analytics to guide future research.
The impacts of moisture transport on drifting snow sublimation in the saltation layer
Authors: Huang Ning , Dai Xiaoqing , Zhang Jie
Published: June 2016

Abstract. Drifting snow sublimation (DSS) is an important physical process related to moisture and heat transfer that happens in the atmospheric boundary layer, which is of glaciological and hydrological importance. It is also essential in order to understand the mass balance of the Antarctic ice sheets and the global climate system. Previous studies mainly focused on the DSS of suspended snow and ignored that in the saltation layer. Here, a drifting snow model combined with balance equations for heat and moisture is established to simulate the physical DSS process in the saltation layer. The simulated results show that DSS can strongly increase humidity and cooling effects, which in turn can significantly reduce DSS in the saltation layer. However, effective moisture transport can dramatically weaken the feedback effects. Due to moisture advection, DSS rate in the saltation layer can be several orders of magnitude greater than that of the suspended particles. Thus, DSS in the saltation layer has an important influence on the distribution and mass–energy balance of snow cover.
Lidar studies on microphysical influences on the structure and lifetime of tropical cirrus clouds
Authors: Motty G. S. , Satyanarayana Malladi , Jayeshlal G. S. , Mahadevan Pillai V. P.
Published: June 2016

Abstract. An understanding of the role of ice crystals in the cirrus cloud is significant on the the radiative budget of the planet and consequent changes in the temperature. The structure and composition of the cirrus is affected by the microphysical parameters and size and fall speed of ice crystal inside the clouds. In this study, the structure and dynamics of tropical cirrus clouds were analysed by the microphysical characterisation using the data obtained by the ground based lidar system over the tropical site Gadanki [13.50° N, 79.20° E], India for a period of 6 years from 2005 to 2010. The observed clouds have optical depth within the range 0.02 to 1.8, lidar ratios are in the 20 to 32 sr range and depolarisation ratio varies between 0.05 and 0.45. The altitude and temperature dependence of the parameters, their interdependence and the fall velocity – effective size analysis were investigated. Dependence of the microphysical parameters on the ice fall velocity which is critical for climate change was also analysed. The same are compared with the CALIPSO satellite based CALIOP lidar observations.
Are flood-driven turbidity currents hot spots for priming effect in lakes?
Authors: Bouffard Damien , Perga Marie-Elodie
Published: June 2016

Abstract. In deep stratified lakes, such as Lake Geneva, flood-driven turbidity currents are thought to contribute to the replenishment of deep oxygen by significant transport of river waters saturated with oxygen into the hypolimnion. The overarching aim of this study was to test this long-standing hypothesis directly. It combines direct observational data collected during an extreme flooding event that occurred in May 2015 with dark bioassays designed to evaluate the consequences of river-borne inputs for the hypolimnetic respiration. The exceptional precipitation events of May 2015 caused floods with an annual return time for the Rhône River, the dominant tributary of Lake Geneva, and with 50-year return time for the Dranse River, the second-most important tributary. Sediment-loaded river flows generated turbidity currents plunging into the lake hypolimnion. The observed river intrusions contributed to the redistribution of dissolved oxygen, with no net gain, when occurring in the lowermost hypolimnetic layer. In the uppermost hypolimnion above the last deep-mixing event, the intrusions coincided with a net oxygen deficit. Consistent with field observations, dark bioassays showed that 1 to 50 % substitution of riverine organic matter to deep (< 200 m) hypolimnetic water did not affect microbial respiration, while the addition of 1 to 10 % of riverine water to the uppermost hypolimnetic waters resulted in a respiration over-yielding, i.e. excess respiration of both river-borne and lacustrine organic matter. The results of our study conflict with the hypothesis that flood-driven turbidity currents necessarily increase hypolimnetic oxygen stocks in Lake Geneva. In contrast, results show that flood-driven turbidity currents can be potential hot spots for priming effect in lakes.
Feasibility for detection of ecosystem response to disturbance by atmospheric carbon dioxide
Authors: Brooks Bjorn-Gustaf J. , Desai Ankur R. , Stephens Britton B. , Michalak Anna M. , Zscheischler Jakob
Published: June 2016

Abstract. Monitoring the terrestrial carbon cycle for responses to disturbances, caused for example by extreme climate events and insect outbreaks, has the potential to provide early warnings about ecosystem change. However, our capability to detect these carbon balance responses by atmospheric CO2 monitoring remains unknown despite sub-ppm comparability of many well-calibrated CO2 measurement sites. Here, this study explores how accurately atmospheric CO2 and transport models can detect imposed carbon flux anomalies against a background terrestrial flux. Air mass back trajectories from three CO2 monitoring stations in the central U.S. Rocky Mountains for one year (2008) were computationally simulated. To simulate reduced CO2 uptake, a constant +0.2 µmol C m−1 s−2 anomaly was added to all surface fluxes within perturbation domains of varying size. A spatially and temporally uniform 10°×10° +0.2 µmol C m−2 s−1 flux anomaly (+6 Tg C m−1) was detectable above a comprehensive model-data mismatch detection threshold in a large majority of months at each site, but only when the perturbation was located in the central Mountain West. The intensity of the perturbation and its area were important to detection, but the effect of area declined exponentially with increasing source-to-station distance. To further evaluate response, a more realistic spatiotemporally varying drought extracted from a dynamic global vegetation model with a monthly varying perturbation area (1°×1° to 5°×5°) and higher peak intensity (+0.8 µmol C m−2 s−1) was applied. Detectability of excess CO2 from this experiment by the nearest CO2 site (Utah) was similar to detectability of the largest (10°×10°) uniform perturbation. These experiments demonstrate disturbance and drought related carbon-cycle perturbations do create a discernible impact on the composite signal of atmospheric CO2 if sufficiently proximal to a measurement station.
Hydraulic and transport parameter assessment using column infiltration experiments
Authors: Younes A. , Mara T. A. , Fahs M. , Grunenberger O. , Ackerer Ph.
Published: June 2016

Abstract. In the present work, we study the quality of the statistical calibration of hydraulic and transport soil properties using an infiltration experiment in which, over a given period, tracer-contaminated water is injected into a laboratory column filled with a homogeneous soil. The numerical model is based on the Richards' equation for solving water flow and the advection-dispersion equation for solving solute transport. Several state variables (e.g., water content, solute concentration, pressure head) are measured during the experiment. Statistical calibration of the computer model is then carried out for different data sets and injection scenarios with the DREAM(ZS) Markov Chain Monte Carlo sampler. The results show that the injection period has a significant effect on the quality of the estimation, in particular, the posterior uncertainty range. The hydraulic and transport parameters of the investigated soil can be estimated from the infiltration experiment using the concentration and cumulative outflow, which are measured non-intrusively. A significant improvement of the identifiability of the parameters is observed when the pressure data from measurements taken inside the column are also considered in the inversion.
The catastrophic landfill flowslide at Hongao dumpsite on December 20, 2015 in Shenzhen, China
Authors: Xu Qiang , Peng Dalei , Li Weile , Dong Xiujun , Hu Wei , Tang Minggao , Liu Fangzhou
Published: June 2016

Abstract. A catastrophic flowslide occurred at Hongao dumpsite at approximately 11:40 AM on Dec 20, 2015, in Guangming New District of Shenzhen, China. The flowslide damaged 33 buildings and caused total death toll of 69 and 8 missing, with the absence of extreme weather condition and seismic activity. The slope failure was analyzed on the basis of multi-temporal remote sensing images, site investigation, in-situ tests, laboratory experiment, and numerical analysis. The preliminary results showed that the volume of the flowslide deposit was 2.32 x 106 m3 and the volume of dumpsite filling was 6.27 x 106 m3 at the time of the event, which is three times larger than the maximum design capacity. The flowslide had the characteristics of high travel speed and long run-out distance, of which the displaced material was primarily silty soil from nearby construction sites with high moisture content. The primary causes of the failure were concluded as follow: (1) The dumpsite stagnated groundwater flow in the study area, which resulted in the saturation of the waste filling and high pore water pressure due to the underlying impermeable granite stratum; (2) The accumulation rate and total volume of the waste filling was in exceedance of the design capacity. The slope failure may be ascribed to excess pore water pressure as liquefaction were observed at many locations and it is postulated that such phenomena was related to the surcharge loads imposed by the unregulated disposal activities.
Brief communication "Loss and Damage from a catastrophic landslide in Nepal"
Authors: van der Geest Kees , Schindler Markus
Published: June 2016

Abstract. This brief communication reports key research findings from studying the impacts of the 2014 Jure landslide in Sindhupalchok (Nepal) and the effectiveness of preventive and coping measures on the household level. The people-centered methods reveal not just what is lost in disasters, but also how and why. A key finding of the household survey is that non-poor households incurred higher losses in monetary terms, simply because they had more to lose. By contrast, poor households lost more in relative terms: The value of their losses amounted to 14 times their annual earnings. Many poor households will never fully recover from this blow to their livelihoods and well-being. The findings have important implications for discussions on loss and damage valuation, compensation and relief.
Seismic structure beneath the Gulf of Aqaba and adjacent areas based on the tomographic inversion of regional earthquake data
Authors: El Khrepy Sami , Koulakov Ivan , Al-Arifi Nassir , Petrunin Alexey G.
Published: June 2016

Abstract. We present the first 3-D model of seismic P and S velocities in the crust and uppermost mantle beneath the Gulf of Aqaba and surrounding areas based on the results of passive travel time tomography. The tomographic inversion was performed based on travel time data from ∼ 9000 regional earthquakes provided by the Egyptian National Seismological Network (ENSN), and this was complemented with data from the International Seismological Centre (ISC). The resulting P and S velocity patterns were generally consistent with each other at all depths. Beneath the northern part of the Red Sea, we observed a strong high-velocity anomaly with abrupt limits that coincide with the coastal lines. This finding may indicate the oceanic nature of the crust in the Red Sea, and it does not support the concept of gradual stretching of the continental crust. According to our results, in the middle and lower crust, the seismic anomalies beneath the Gulf of Aqaba seem to delineate a sinistral shift (∼ 100 km) in the opposite flanks of the fault zone, which is consistent with other estimates of the left-lateral displacement in the southern part of the Dead Sea Transform fault. However, no displacement structures were visible in the uppermost lithospheric mantle.
Formación del licenciado en Enfermería en América Latina
Authors: Luengo-Martínez Carolina Elena , Sanhueza-Alvarado Olivia
Published: June 2016

Antecedentes: actualmente, América Latina requiere profesionales en Enfermería cuyo perfil de egreso pueda responder a los cambios que ha traído consigo la globalización. Se sabe que la formación del licenciado en Enfermería es disímil en los países de América Latina e, incluso, al interior de estos. Objetivo: describir la formación del licenciado en Enfermería en América Latina en términos de plan de estudio, reglamentación u organismos regulatorios, tiempo, requisitos de egreso y perfil del licenciado. Materiales y método: revisión bibliográfica de las páginas web de universidades latinoamericanas que forman licenciados en Enfermería; los criterios de inclusión fueron: ranking de universidades del país (cuando existía), universidades con página web actualizada y disponibilidad de la información. Conclusión: se constata la heterogeneidad en la formación del licenciado en Enfermería en América Latina, que puede ser un factor de debilitamiento para la disciplina así como para la profesión. Se sugiere un consenso sobre una formación curricular común en la región, que apunte a un perfil profesional apropiado, que proporcione la capacidad de enfrentar y satisfacer las necesidades que traen consigo los desafíos de nuestro tiempo.
Obesidad infantil y su relación con indicadores cardiopulmonares en escolares mexicanos
Authors: Arias-Rico José , Cortés-Cortés Sandy Marlene , Ramírez-Moreno Esther , Sánchez-Padilla Ma. Luisa , Jiménez-Sánchez Reyna Cristina , Saucedo-Molina Teresita de Jesús
Published: June 2016

Objetivo: determinar la relación entre obesidad y anormalidades de parámetros cardiopulmonares en escolares. Materiales y métodos: participaron 78 escolares entre 5 a 11 años de edad, 47 hombres (60,3 %) y 31 mujeres (39,7 %), pertenecientes a una escuela primaria particular de la ciudad de Pachuca (México). Se evaluó: índice de masa corporal (IMC), circunferencia de cintura (CC), grasa corporal (GC), frecuencia cardiaca (FC), presión arterial (PA), frecuencia respiratoria (FR) y espirometría. Se emplearon las pruebas estadísticas chi-cuadrado (x2), odds ratio y correlación de Spearman (rs). Resultados: 23,1 % de los escolares evaluados presentaron sobrepeso y 29,5 %, obesidad. El 38,5 y 11,5 % presentaron FC y PA superiores a los parámetros normales, respectivamente; 3,8 % de la población presentó FR arriba del promedio y 11,5 % mostró valores espirométricos anormales. Se encontraron relaciones entre IMC con GC y CC, GC y CC, CC y FC, GC y PA, y FC y FR. Conclusiones: las prevalencias de sobrepeso y obesidad obtenidas en este estudio fueron altas. Los niños con sobrepeso u obesidad podrían tener mayor riesgo de presentar anormalidades cardiopulmonares en comparación con niños de peso normal. Se sugiere continuar con estudios en el tema en una muestra más amplia.
Management of Continuous Positive Airway Pressure in the Newborn: Impact of Lecture-based Interactive Workshops on Training for Neonatal Intensive Care Nurses
Authors: Tiryaki Öznur , Cinar Nursan
Published: June 2016

Objetivos: el objetivo de este estudio fue determinar cómo la formación impartida a través de talleres estructurados relacionados con el manejo de la presión positiva continua en las vías respiratorias en el recién nacido afecta el conocimiento de las enfermeras que trabajan en cuidados intensivos neonatales. Métodos: un grupo de enfermeras asistieron a un taller interactivo basado en una conferencia sobre el manejo de la presión positiva continua en las vías respiratorias en el recién nacido. Las enfermeras en cuestión habían aceptado una invitación para asistir a la presentación antes del evento de capacitación. La información sobre las características diferenciadoras de los participantes se recogió a través de un cuestionario elaborado por los propios investigadores. Una evaluación de los conocimientos de las enfermeras sobre el tema se llevó a cabo a través de un cuestionario de selección múltiple (CSM), el cual fue elaborado por los investigadores en relación con la literatura. El CSM fue enviado por correo a unos expertos en Turquía (siete personas) y unos expertos en el exterior (cinco personas), y sus opiniones fueron tomadas en cuenta. A la luz de sus sugerencias, al CSM se le dio su forma final y el número de preguntas se fijó en 20. El CSM, que consta de 20 preguntas, fue respondido por los participantes antes y después del taller interactivo. A los participantes no se les dijo si la prueba se repitió después del taller de formación. Resultados: treinta y seis enfermeras de la unidad neonatal participaron en el estudio. Cada pregunta en el CSM se consideró como un (1) punto. La puntuación máxima posible en la prueba fue 20. Hubo una mejora significativa en la puntuación de la prueba media después de la conferencia, si se compara con la puntuación preconferencia (media = 19,6, SD = 0,8 vs. media = 13,1, SD = 3.0, P <0,001). Conclusiones: un taller interactivo basado en una conferencia sobre el manejo de la presión positiva continua en las vías respiratorias en el recién nacido ayuda a mejorar el conocimiento de las enfermeras. También ayuda a superar las deficiencias en la formación de enfermeras.
Investigate the Factors Affecting on the Organizational Development from the Point of View of Managers and Specialists in Sari City Region one Education Department
Authors: Ahmadianchashmi Mina
Published: June 2016

The main purpose of the paper, the analysis of the effective factors on the organizational development from the point of view of managers and specialists in Sari city region one education department, was designed and performed, the specific objectives of which include: knowing the structure, management system, organizational culture, duties description, regulation status and methods and information technology in the organizational development of Sari region one education department. The method of research in this study was descriptive, of the field finding type. The statistical population of the study included 90 managers and education specialists of Sari region one which, based on Morgan’s table, 73 managers and specialists were selected as the samples. The data gathering tool was the researcher made questionnaire with 33 items with five choice spectrum.Using the indices descriptive statistics (frequency distribution of mean and standard deviation and error of mean deviation) and inferential statistics (one variable T-test and variance analysis) and to analyze the normality of variables (Colmogrov-Smearnov tests) are used. Also, the SPSS software is used. Findings show that different factors are suitable in the organizational development of Sari region one. The official structure, the management organizational organization, the organizational culture, duty description, regulation status, methods and information technology are effective in the organizational development of Sari region one education department. And also, the features of duty description and information technology are the most effective ones on the organizational development and the attitude of the specialists and managers are effective on the effective factors on the organizational and development of Sari city region one education department.
La importancia de la autoevaluación de las carreras de posgrado
Authors: Aguilar Leslie
Published: June 2016

Revista Ciencia y Tecnología No. 17, diciembre 2015 pp.3-12
La autoevaluación: una mejora continua de las carreras de posgrado
Authors: Green Arrechavala Ivy Lou , Julisa López Virna
Published: June 2016

Revista Ciencia y Tecnología No. 17, diciembre 2015, pp.15-20
Actitud hacia la estadística por parte de los estudiantes de Medición Psicológica de la UNAH, 2015
Authors: Landa Blanco Miguel
Published: June 2016

La presente investigación tuvo como objetivo principal conocer la actitud hacia la estadística por parte de los estudiantes de las clases de Medición Psicológica, de la UNAH, durante el primer período académico de 2015. El abordaje se realizó con un enfoque cuantitativo de alcance descriptivo. Para ello se tomó una muestra de 316 alumnos a los cuales se les aplicó la escala de actitudes hacia la estadística (Auzmendi, 1992), versión validada por Tejero y Castro (2011).Los resultados indican que el 16 % de los sujetos manifiestan una actitud negativa hacia la estadística, mientras que el 43 % de los alumnos se muestra indiferente ante ella y el 41 % tiende a tener actitudes favorables hacia tal disciplina.El análisis por factores indica que existe resistencia por parte del alumno a involucrarse en asignaciones con carga estadística. Igualmente, se reconoce la utilidad de la estadística en la psicología, pero existe renuencia a relacionarse personalmente en tareas relacionadas con tal disciplina. Se encontró que la actitud hacia la estadística no varía en función de la asignatura que cursa el alumno, finalmente se concluye que, dentro de la muestra de estudio, los hombres tienden a mostrar una mejor actitud hacia la estadística que las mujeres.Revista Ciencia y Tecnología No. 17, diciembre 2015 pp.68-78
Flora de la ciudad universitaria, UNAH: un proyecto de ciencia ciudadana realizado por estudiantes universitarios
Authors: Ferrufino Lilian , Oyuela Olvin , Sandoval German , Francia Beltrán Francia
Published: June 2016

Las áreas urbanas constituyen sitios fragmentados de los ecosistemas naturales, convirtiéndose en barreras entre las poblaciones de plantas y animales que habitan en ellas. En la ciudad universitaria se han realizado varios inventarios para contribuir a los estudios de impacto ambiental como un requisito para la construcción de edificios en el área, en consecuencia, este estudio tiene como objetivo hacer un inventario florístico del campus.Para la colecta se estableció la zonificación de la ciudad universitaria: áreas verdes de la parte frontal y central, Palacio de los Deportes, Facultad de Ingeniería y al Observatorio Astronómico. Se colectaron las muestras en flor y fruto durante un año y estas fueron colectadas por los estudiantes de las clases de Taxonomía vegetal I y Taxonomía vegetal II.Se identificaron usando claves dicotómicas, ejemplares depositados en el herbario y con la colaboración de expertos. Se identificaron cerca 172 especies, pertenecientes a 55 familias, de estas las más comunes son: Fabaceae, Myrtaceae y Asteraceae. Los grupos de plantas que predominan en el área son las angiospermas, con un bajo porcentaje de helechos y gimnospermas. Este estudio servirá de base para proponer un plan de mejoramiento ambiental, ya que la ciudad universitaria constituye uno de los espacios para el conocimiento de la flora urbana de Tegucigalpa. Además, estas acciones contribuirán a impulsar el desarrollo local y la participación de estudiantes universitarios en la investigación científica.Revista Ciencia y Tecnología No. 17, diciembre 2015 pp.112-131
Un análisis descriptivo sobre el producto financiero denominado “factoraje” en Honduras, periodo 2015-2016
Authors: Argueta Moreno Jesús David
Published: June 2016

El factoraje es un instrumento de financiamiento que las empresas pueden utilizar para atender necesidades de capital de corto plazo, de gestión de cobranza y coberturas de riesgo crediticio, entre otros servicios. Las dificultades de acceso al crédito por la presencia de asimetrías de información en los mercados financieros, impulsan la búsqueda de fuentes de financiamiento alternativa, entre ellas el factoraje, en particular en el caso de las PYME. Adicionalmente, la provisión de otros servicios anexados al propio financiamiento realiza su potencialidad. Por otro lado, dentro de los diferentes tipos de factoraje, el internacional constituye un catalizador para el mejoramiento en la operatividad y acceso a los mercados internacionales. Si bien el volumen de factoraje en el mundo ha aumentado en los últimos años, en Honduras todavía no se encuentra ampliamente difundido, encontrándose entre los niveles más bajos de la región.El presente análisis describe la temática denominada como factoraje financiero, explora sus métricas, sus dimensiones, así como la identificación de productos similares al factoraje en el contexto hondureño local; señalando sus bondades y condicionantes, los cuales deberán de ser evaluados por las empresas, al momento de requerir este tipo de servicios.Luego de explorar el sustento empírico, atinente a la herramienta del confirming, se infiere que este mecanismo financiero en Honduras, abona de forma significante a la gestión de la tesorería de las empresas que lo utilizan, sin embargo este no es sostenible en el tiempo, debido a las distintas fisuras competitivas del contexto local y regional, que condicionan el flujo de insumos requeridos para que los procesos financieros del factoraje, que mitigan los flotantes comerciales y financieros, se gestionen de manera eficiente, eficaz e ininterrumpida.Revista Ciencia y Tecnología No. 17, diciembre 2015 pp.160-175
Eyecciones coronales de masa solar a 1 unidad astronómica
Authors: Guerrero Vásquez Maribel S.
Published: June 2016

La presente investigación concluye estadísticamente que las eyecciones coronales de masa solar (CME) por sus siglas en inglés, son grandes erupciones de campos magnéticos coronales solares y plasma (considerado el cuarto estado de la materia), que alcanzan la órbita de la Tierra con características especiales de velocidad, en este caso específico estudiado, se convierten en tormentas geomagnéticas, de alta o baja velocidad, según las CME.Para desarrollar la presente investigación se estudiaron los datos de eyecciones coronales de masa solar con propiedades delimitadas: de velocidad, masa y diferentes tipos de energía del año 1990 al 2012 que pudieron convertirse en tormentas geomagnéticas. Se enfocó la investigación en eventos rápidos con un rango de tiempo mayor o igual a 0.5 días y menor o igual a 1 día, para calcular el tiempo de llegada al planeta Tierra en días; se usó la distancia promedio entre nuestro planeta y el Sol.De los datos de CME de altas velocidades, tenemos como resultados pocas fluctuaciones del campo magnético, o sea, pocas tormentas geomagnéticas; pero se observaron valores de índices k desde 0 a 9. En general, haciendo un análisis comparativo de los resultados de la caracterización de eyecciones coronales con la actividad solar, se observó que los ciclos de máxima actividad fueron atípicos, concluyendo que realmente los ciclos mínimos se han prolongado, se resalta la tendencia decreciente en la actividad solar y como consecuencia también hay tendencia decreciente en la ocurrencia de eyecciones coronales de masa que son la principal causa de las tormentas geomagnéticas.Revista Ciencia y Tecnología No. 17, diciembre 2015 pp.179-194
Current Status and Future Prospects for Aptamer-Based Mycotoxin Detection
Authors: Ruscito Annamaria , Smith McKenzie , Goudreau Daniel N , DeRosa Maria C
Published: June 2016

Aptamers are single-stranded oligonucleotides with the ability to bind tightly and selectively to a target analyte. High-affinity and specific aptamers for a variety of mycotoxins have been reported over the past decade. Increasingly, these molecular recognition elements are finding applications in biosensors and assays for the detection of mycotoxins in a variety of complex matrixes. This review article highlights the mycotoxin aptamers that are available for mycotoxin detection and the array of biosensing platforms into which they have been incorporated. Key advantages that aptamers have over analogous technology, and areas in which these advantages may be applied for the benefit of practical mycotoxin detection, are also discussed.
A Low-Cost Open Source 3D-Printable Dexterous Anthropomorphic Robotic Hand with a Parallel Spherical Joint Wrist for Sign Languages Reproduction
Authors: Bulgarelli Andrea , Toscana Giorgio , Russo Ludovico Orlando , Farulla Giuseppe Airò , Indaco Marco , Bona Basilio
Published: June 2016

We present a novel open-source 3D-printable dexterous anthropomorphic robotic hand specifically designed to reproduce Sign Languages’ hand poses for deaf and deaf-blind users. We improved the InMoov hand, enhancing dexterity by adding abduction/adduction degrees of freedom of three fingers (thumb, index and middle fingers) and a three-degrees-of-freedom parallel spherical joint wrist. A systematic kinematic analysis is provided. The proposed robotic hand is validated in the framework of the PARLOMA project. PARLOMA aims at developing a telecommunication system for deaf-blind people, enabling remote transmission of signs from tactile Sign Languages. Both hardware and software are provided online to promote further improvements from the community.
La copia de escrituras públicas a la muerte del notario titular
Authors: Antuña Castro Roberto
Published: June 2016

Este trabajo estudia el proceso observado en la extensión de aquellos instrumentos públicos que no han llegado a formalizarse ni, por tanto, a entregarse a las partes, por la muerte del notario titular que había estado presente a su otorgamiento y que había recogido en su libro registro. Aunque en la legislación alfonsina se establece de manera contradictoria cómo se debía actuar, la práctica nos muestra cómo se hace necesaria la intervención judicial para que esas escrituras se expidiesen con todo su valor legal. Para ello, el interesado acude a la autoridad judicial para que dé su licencia al oficial sucesor en la notaría para confeccionar la carta, previa comprobación de la autenticidad de las notas encontradas en el registro que ha dejado el escribano finado. Gracias a este estudio realizamos una aportación sobre una realidad que en parte nos era desconocida: el procedimiento seguido para valerse del registro de un notario fallecido y redactar una escritura definitiva y completa a partir de él.This study analyzes the process of issuing public documents which have not been certified and, consequently, have not been handed over to the parties concerned as a result of the death of the notary who was present at the time it was submitted and who was responsible for recording it in the register. Even though legislation adopted under Alfonso X made these norms confusing, in practice we can observe how judicial intervention was necessary in order for these notarial deeds to be legally binding. It was essential for the individual concerned to turn to the judicial authorities who could grant a licence to the successor of the notary in order to prepare a deed having previously checked the authenticity of the draft found in the deceased notary’s register. This study provides insight into an issue that was previously ill-known, namely the procedure undertaken to produce a formal and definitive deed based on the register of a deceased notary.
Les dispositifs d’intervention clinique en institution
Authors: Pinel Jean-Pierre
Published: June 2016

Cet article présente de manière synthétique la théorisation et la découpe originales de l’intervention clinique en institution en référence au modèle que Jean-Claude Rouchy nous a proposé. Il présente et discute trois repères essentiels à la compréhension de sa démarche méthodologique : le concept de dispositif ; la place de l’analyste ; les différents dispositifs d’analyse en institution. Ce modèle offre un repérage particulièrement précieux pour le clinicien, trouvant ainsi un adossement fiable et consistant lui permettant de résister créativement à la déliaison, voire au chaos, qu’il rencontre de plus en plus massivement dans sa clinique d’intervention, soumise aux bouleversements du méta-cadre contemporain.
La fonction narcissique de la fantasmatique filiale chez les adoptés internationaux
Authors: Boivin Mylène , Hassan Ghayda
Published: June 2016

Les enfants adoptés à l’international sont confrontés à de nombreuses inconnues en ce qui a trait à leur histoire et tout particulièrement à leur filiation. Ils doivent alors avoir davantage recours à leur imagination et à une fantasmatique intérieure afin de construire leur identité. La présente étude a pour but de mettre en lumière quelle fonction occupe la famille biologique dans l’économie psychique des adolescents adoptés à l’international. Des entrevues semi-structurées ont été menées auprès de 13 adolescents adoptés de pays d’Asie. L’analyse thématique de ces données indique que, grâce à la fantasmatique développée autour de la famille d’origine, les jeunes adoptés à l’international parviennent à se renarcissiser devant les écueils, le non-dit et l’absence d’information vis-à-vis leur filiation d’origine et les circonstances entourant leur adoption. Les implications cliniques sont discutées et des recommandations sont formulées.
« L’enfant-dossier » : la bienveillance au risque de sa perversion
Authors: Aubourdy Florence
Published: June 2016

L’évaluation, nouvelle égérie technico-scientifique, pilotant la réforme du système structurel et le style de gestion des écoles, dans un souci d’efficacité et d’efficience, déshumanise les pratiques pédagogiques et développe un climat anxiogène, peu propice à l’apprentissage. Cette impasse du désir, par une logique d’« enfant-dossier », menace les structures symboliques et la construction même de la pensée. Cette répétition perverse dévoile la face obscure des bonnes intentions, réminiscence du passé de l’Occident.
Le tutorat par les pairs en contexte universitaire. Une étude de cas
Authors: Papaïoannou Ilias-Vasileios , Tsioli Sofia , Vihou Marina
Published: June 2016

Le but de l’article est de décrire une expérience éducative réalisée en contexte universitaire, afin de discuter de la contribution du tutorat par les pairs au développement de la compétence pédagogique des futurs et novices enseignants de FLE. L’étude de cas en question a duré tout au long d’un semestre académique et a impliqué des étudiants du 1er et du 2e cycle.
Theoretical and experimental determination of the crystal structures of cesium–molybdenum chloride
Authors: Saito Norio , Wada Yoshiki , Lemoine Pierric , Cordier Stéphane , Grasset Fabien , Ohsawa Takeo , Saito Noriko , Cross Jeffrey S. , Ohashi Naoki
Published: June 2016

We herein report the structure-property relationships of the octahedral molybdenum metal cluster compound, Cs2[Mo6Cl14]. Using purified samples, we attempted to determine if Cs2[Mo6Cl14] possesses crystalline polarity. Heat treatment was performed prior to characterization to remove impurities, as X-ray powder diffraction and Fourier transformation infrared spectroscopy studies suggested the unit cell of Cs2[Mo6Cl14] expanded with the insertion of water molecules and/or hydroxyl moieties. Geometry optimization and total energy calculations by density functional theory calculations were conducted to determine whether Cs2[Mo6Cl14] crystallizes in centrosymmetric (

) or non-centrosymmetric (P31c) space groups. Furthermore, the results of the optical studies, along with the absence of a second harmonic generation, and the observation of a strong third harmonic generation, supported the hypothesis that inversion symmetry exists in the Cs2[Mo6Cl14] lattice. The space group of Cs2[Mo6Cl14] was therefore identified as

symmetry.
SUBJETIVIDADE, INTERDISCIPLINARIDADE E DISCURSO DAS CIÊNCIAS HUMANAS NO PENSAMENTO DE JACQUES DERRIDA
Authors: Pinto Aline Magalhães
Published: June 2016

A proposta desse texto é identificar a crítica de Derrida à subjetividade moderna para, em seguida, mapear o impacto dessa crítica e inflexão, apontando a tradução – no sentido que lhe é atribuído por Derrida-, como possibilidade em aberto para a construção do discurso das ciências humanas.
“QUANDO VOCÊ GANHA PESO, VOCÊ COMEÇA A 'FUGIR' DA BALANÇA E DA FITA MÉTRICA”: UMA ESCUTA DISCURSIVA DA ESCRITA TECIDA POR ADOLESCENTES SOBRE AS RELAÇÕES ENTRE CORPO, MÍDIA E SOCIEDADE
Authors: Prawucki Rubens
Published: June 2016

O objetivo deste artigo é analisar, através dos pressupostos teórico-metodológicos da Análise de Discurso Francesa (PÊCHEUX, 2002), como se dá a construção de sentidos sobre as relações entre corpo, mídia e sociedade na escrita de quatro adolescentes estudantes do ensino médio. O que motivou a escrita desses adolescentes foi uma peça publicitária que explora o culto ao corpo, extraída da mídia brasileira contemporânea. As análises mostram que os mecanismos para a produção de sentidos sobre a questão do corpo na escrita dos adolescentes geram efeitos de sentidos muitas vezes contraditórios, resultado dos contextos social, histórico e ideológico também serem marcados por contradições.
COLOCANDO O SEXO EM DISCURSO: OLHARES DE FOUCAULT SOBRE A PSICANÁLISE
Authors: Silveira Ederson Luís
Published: June 2016

O presente trabalho qualitativo de natureza documental e bibliográfica visa trazer discussões acerca das relações entre Foucault e a psicanálise. Neste contexto, as reflexões de Joel Birman e de Ernani Chaves se tornam profícuas e, considerando a leitura de algumas obras de Foucault, sobretudo do primeiro volume da História da Sexualidade, serão retomados alguns pontos de embates e problematizações sob o viés foucaultiano como aquele que emerge não para deslegitimar o papel e o lugar da psicanálise, mas a partir de reflexões que se voltam para questões concernentes aos modos em relação ao que tornou esta possível enquanto discurso científico.
UM OLHAR SEMÂNTICO SOBRE O CONTEÚDO DOS LIVROS DIDÁTICOS DO ENSINO MÉDIO
Authors: Santos Ednaldo Tartaglia , Jorrin Maria Do S. D. Loura
Published: June 2016

RESUMO: O presente trabalho tem por objetivo verificar como ou se os estudos semânticos estão sendo inseridos nos materiais didáticos do Ensino Médio propostos para as escolas públicas brasileiras. O nosso corpus de estudo foi o livro Português: volume único (MAIA, 2005) e as coleções Língua Portuguesa: Linguagem e Interação (FARACO et al., 2010) e Português Linguagens (CEREJA; MAGALHÃES, 2010), todos distribuídos pelo Ministério da Educação - MEC. Com a análise dos materiais, observamos que alguns autores têm resistência em utilizar e incluir em suas obras os estudos dos significados ou a palavra semântica, em contrapartida, encontramos autores que tiveram tal preocupação na organização dos materiais didáticos.
O DISCURSO LITERÁRIO SOBRE AS MASCULINIDADES NOS ANOS 1970: DUAS CRÔNICAS DE LUIS FERNANDO VERISSIMO
Authors: Simon Luiz Carlos
Published: June 2016

O artigo pretende examinar, sob a perspectiva das masculinidades, parte da produção literária brasileira antes da maior difusão da temática como objeto de estudos e de sua circulação nas diversas expressões da vida cultural. Para favorecer essa avaliação, é feito um levantamento dos últimos quarenta anos quanto aos debates acadêmicos sobre o assunto, autores brasileiros, como Xico Sá e Carpinejar, que escreveram textos nos quais a questão se destaca, e programas televisivos que enfatizam particularidades do comportamento masculino contemporâneo. A análise está concentrada em duas crônicas de Luis Fernando Verissimo escritas e publicadas ainda no início de sua carreira, nos anos 1970, para permitir uma melhor compreensão do retrato de homens construído pelo autor antes da disseminação maior da questão verificada no século XXI. Os resultados, com base na articulação de uma leitura em busca do perfil das masculinidades apresentado nos textos com a investigação sobre o material teórico em torno do assunto, apontam para uma visão crítica e irônica sobre práticas masculinas já naquele tempo.
PLACAS PARA FORRO PRODUZIDAS COM COMPÓSITO DE GESSO E EPS RECICLADOS
Authors: Rohden Abrahão Bernardo , Mecabô Rodolfo Antônio
Published: June 2016

O gesso e o poliestireno expandido (EPS) são amplamente utilizados na construção civil. Apesar de serem materiais conhecidos há bastante tempo, as tecnologias de reintrodução dos rejeitos destes materiais na cadeia produtiva ainda encontram desafios. O objetivo deste estudo constituiu-se no desenvolvimento de placas para serem empregadas em forro a partir de um compósito de gesso e EPS reciclados. A metodologia utilizada consistiu no beneficiamento e na caracterização do gesso reciclado, comparando o mesmo ao gesso comercial e as exigências normativas. Foram produzidas pastas com o gesso reciclado buscando compreender seu comportamento em função da relação água/gesso. A partir do comportamento da pasta foi então produzido o compósito com adição de três teores de EPS reciclado de 5, 10 e 15 g. Moldaram-se, então, placas com as quais se realizou os ensaios de resistência à tração na flexão e massa específica. Os resultados mostram que as pastas de gesso reciclado com relação água:gesso igual a 1 e os compósitos com 5 e 10 g de EPS reciclado são adequados para produção de placas para forro quanto à resistência à tração na flexão e massa específica.
Private Equity Acquisition of Physician Practices—Looking for Ethical Guidance From Professional Societies
Authors: Ubel Peter A.
Published: September 2024

This Viewpoint recommends that professional medical societies provide ethical guidance on private equity acquisitions of physician practices.
A Machine Learning Method for Allocating Scarce COVID-19 Monoclonal Antibodies
Authors: Xiao Mengli , Molina Kyle C. , Aggarwal Neil R. , Beaty Laurel E. , Bennett Tellen D. , Carlson Nichole E. , Fish Lindsey E. , Hamer Mika K. , Kwan Bethany M. , Mayer David A. , Peers Jennifer L. , Wynia Matthew K. , Ginde Adit A.
Published: September 2024

Importance

During the COVID-19 pandemic, the effective distribution of limited treatments became a crucial policy goal. Yet, limited research exists using electronic health record data and machine learning techniques, such as policy learning trees (PLTs), to optimize the distribution of scarce therapeutics.

Objective

To evaluate whether a machine learning PLT-based method of scarce resource allocation optimizes the treatment benefit of COVID-19 neutralizing monoclonal antibodies (mAbs) during periods of resource constraint.

Design, Setting, and Participants

This retrospective cohort study used electronic health record data from October 1, 2021, to December 11, 2021, for the training cohort and data from June 1, 2021, to October 1, 2021, for the testing cohort. The cohorts included patients who had positive test results for SARS-CoV-2 and qualified for COVID-19 mAb therapy based on the US Food and Drug Administration’s emergency use authorization criteria, ascertained from the patient electronic health record. Only some of the qualifying candidates received treatment with mAbs. Data were analyzed between from January 2023 to May 2024.

Main Outcomes and Measures

The primary outcome was overall expected hospitalization, assessed as the potential reduction in overall expected hospitalization if the PLT-based allocation system was used. This was compared to observed allocation using risk differences.

Results

Among 9542 eligible patients in the training cohort (5418 female [56.8%]; age distribution: 18-44 years, 4151 [43.5%]; 45-64 years, 3146 [33.0%]; and ≥65 years, 2245 [23.5%]), a total of 3862 (40.5%) received mAbs. Among 6248 eligible patients in the testing cohort (3416 female [54.7%]; age distribution: 18-44 years, 2827 [45.2%]; 45-64 years, 1927 [30.8%]; and ≥65 years, 1494 [23.9%]), a total of 1329 (21.3%) received mAbs. Treatment allocation using the trained PLT model led to an estimated 1.6% reduction (95% CI, −2.0% to −1.2%) in overall expected hospitalization compared to observed treatment allocation in the testing cohort. The visual assessment showed that the PLT-based point system had a larger reduction in 28-day hospitalization compared with the Monoclonal Antibody Screening Score (maximum overall hospitalization difference, −1.0% [95% CI, −1.3% to −0.7%]) in the testing cohort.

Conclusions and Relevance

This retrospective cohort study proposes and tests a PLT method, which can be linked to a electronic health record data platform to improve real-time allocation of scarce treatments. Use of this PLT-based allocation method would have likely resulted in fewer hospitalizations across a population than were observed in usual care, with greater expected reductions than a commonly used point system.