bluuebunny/crossref_metadata_2025 huggingface dataset:
Aspects of Relevance of Hybrid Power Plants in Control and Stability of Weak Grids
Authors: Shahnazian Fatemeh , Das Kaushik , Yan Ruifeng , Sørensen Poul
Published: December 2024

This paper reviews the possible contributions of Hybrid Power Plants (HPPs) to support weak grids while maintaining the desired system stability. Moving towards a converter-dominant power system with less inherent inertia and distant connections to the nearest synchronous generator, frequency and voltage controls are becoming more critical to ensure the stability of the weak grid. In this regard, state-of-the-art literature is reviewed for frequency and voltage controllers in single-technology power plants, like wind and solar power plants. The contribution of this paper lies in providing a clear overview of available literature in terms of frequency and voltage control stages, regardless of the utilized control method. On the other hand, focus has been put on the increased utilization of HPPs to provide more flexibility, increased availability, and reduced variability through the combination of various sources, i.e., wind, solar, and storage. Furthermore, investigating the specific capabilities and challenges of HPPs, this review shows that very little literature has been conducted on voltage control using HPPs. Finally, the aspect of relevance of HPPs is discussed in the control and stability of modern power systems.
A Critical Review of Overheating Risk Assessment Criteria in International and National Regulations—Gaps and Suggestions for Improvements
Authors: Sadeghi Mahsan , Chen Dong , Wright Anthony
Published: December 2024

The escalating environmental threat of indoor overheating, exacerbated by global climate change, urbanisation, and population growth, poses a severe risk to public health worldwide, specifically to those regions which are exposed to extreme heat events, such as Australia. This study delves into the critical issue of overheating within residential buildings, examining the existing state of knowledge on overheating criteria and reviewing overheating guidelines embedded in (a) international standards and (b) national building codes. Each regulatory document is analysed based on its underlying thermal comfort model, metric, and indices. The advantages and limitations of each document are practically discussed and for each legislative document and standard, and the quantitative measures have been reviewed, analysed, and summarised. The findings illuminate a global reliance on simplistic indices, such as indoor air temperature and operative temperature, in the existing regulatory documents. However, other critical environmental parameters, such as relative humidity, indoor air velocity, and physiological parameters including metabolic heat production and clothing insulation, are often not included. The absence of mandatory regulations for overheating criteria in residential buildings in some countries, such as in Australian homes, prompts the call for a holistic approach based on a thermal index inclusive of relevant environmental and physiological parameters to quantify heat stress exposure based on human thermal regulation. Gaps and limitations within existing guidelines are identified, and recommendations are proposed to strengthen the regulatory framework for overheating risk assessment in residential buildings. The findings hold significance for policymakers, building energy assessors, architects, and public health professionals, providing direction for the improvement of existing, and development of new, guidelines that aim to enhance indoor thermal condition and population health while ensuring energy efficiency and sustainability in the building stock.
Model Predictive Hybrid PID Control and Energy-Saving Performance Analysis of Supercritical Unit
Authors: Yang Qingfeng , Chen Gang , Guo Mengmeng , Chen Tingting , Luo Lei , Sun Li
Published: December 2024

In response to the escalating challenges of rapid load fluctuations and intricate operating environments, supercritical power units demand enhanced control efficiency and adaptability. To this end, this study introduces a novel model predictive hybrid PID control strategy that integrates PID with model predictive control (MPC), leveraging the operational characteristics of multi-loop systems. The proposed strategy adeptly marries the swift response of PID controllers with the foresight and optimization capabilities of MPC. A dynamic model of a supercritical unit is constructed using the subspace identification method. The model’s high precision is confirmed by its alignment with field data. Load change simulations demonstrate that the PID–MPC hybrid controller shows faster response times and more precise tracking capabilities compared to the feedforward-PID strategy. It achieves substantial improvements in the IAE index for three loops, with increases of 29.2%, 54.1%, and 57.3% over the feedforward-PID controller. An energy-saving performance analysis indicates that the proactive control actions of both the PID–MPC and MPC strategies lead to dynamic exergy efficiency and coal consumption rates with a broader range of dynamic process changes. The disturbance scenario simulation regarding the proposed controller achieves faster settling times and minimizes control deviation compared to the traditional controller.
Fabrication of Black Silicon Antireflection Coatings to Enhance Light Harvesting in Photovoltaics
Authors: Dhoska Klodian , Spaho Evjola , Sinani Uljan
Published: December 2024

Black silicon has attracted significant interest for various engineering applications, including solar cells, due to its ability to create highly absorbent surfaces or interfaces for light. It enhances light absorption in crystalline solar cells, improving the efficiency of converting incident light into electricity for photovoltaic applications. This research focused on fabricating nanostructures that played a critical role in enhancing light absorption in the upper layers of solar cells. These nanostructures were created using the black silicon method, forming a layer known as “black silicon”. The coating not only improved the efficiency of crystalline solar cells but also enhanced their stability. The antireflection coating, composed of nanostructures with various shapes, including conical, pillar-like, and spike-like forms, achieved a reflectivity as low as 10% in the spectral range of 400–700 nm. This corresponded to a sample with α = 0.85 and a chuck bias of 4 W. An Inductively Coupled Plasma Reactive Ion Etching (ICP RIE) machine was employed to develop and control the specific shape, size, and density of the fabricated black silicon, which was then subjected to testing. The efficiency of the black silicon photovoltaic cell was 23.3%.
Shape Accuracy Improvement of the Flange Turning Process in Aluminum Aerosol Can Production
Authors: Sztankovics Istvan , Felho Csaba , Kun-Bodnar Krisztina , Maros Zsolt
Published: December 2024

This study investigates the flange turning process in the production of aluminum aerosol bottles. Aluminum discs are lubricated, extruded, trimmed, washed, painted, and lacquered before undergoing necking, where flange turning ensures a secure, aesthetically pleasing fit. Errors in flange turning, such as uneven or tapered surfaces, can compromise bottle functionality and appearance. To address this, experiments were performed with different tool geometries, feed rates, and rotational speeds. The investigations aimed to achieve flat, consistent flange surfaces with minimal deviation from the desired geometry. Two main variables were examined: a 1 s waiting time at the end position and variations in feed rate and cutting depth. The waiting time improved flatness, halving surface deviations, while regrinding the tool reduced flatness errors to a tenth of the original values. Higher feed rates and speeds also enhanced surface quality, with flatness errors ranging from 371 μm to 75 μm. Overall, this study demonstrates that optimizing parameters like cutting angle, feed rate, and rotational speed, along with a waiting period, significantly enhances surface accuracy. These findings support more efficient production processes for aluminum aerosol bottles.
Impact of a Complex Passivating Agent on Heavy Metal Immobilization in Pig Manure and Plant Development
Authors: Li Yutong , Zhao Hongyan , Liang Xuanhe , Zhao Xin , Li Shanlong , Oh Kokyo , Jiang Dengyu , Li Tao , Cao Tiehua
Published: December 2024

In order to immobilize heavy metals in livestock and poultry manure and promote the safe utilization of pig manure resources, this experiment utilized three types of dried pig manure mixed with soil as raw materials. A combination of biochar and bentonite was established, including treatments with the addition of pig manure (CZ), 2.5% bentonite (F1), 7.5% bentonite (F2), 2.5% biochar (F3), 7.5% biochar (F4), 2.5% biochar + 2.5% bentonite (F5), 2.5% biochar + 7.5% bentonite (F6), 7.5% biochar + 2.5% bentonite (F7), 7.5% biochar + 7.5% bentonite (F8), and with zero addition (CK). After the passivation treatments had been applied, a soybean pot experiment was established to measure various physiological indicators at different soybean development stages. The results revealed that the passivated Cu was predominantly in the reduced and residual states. The passivation rates for F8 in LPS, F7 in MPS, and F8 in HPS were 34.10%, 29.90%, and 39.50%, respectively. Among the three concentrations of a pig manure–soil mixture, the impact of low copper concentration on soybean growth was relatively minimal, whereas medium and high copper concentrations significantly impaired soybean health, resulting in varying degrees of interveinal chlorosis and leaf yellowing from the tip to the base of young leaves, thereby affecting photosynthesis. The combined application of biochar and bentonite enhanced copper passivation and facilitated soybean growth and development.
Voluntary Blood Donation in Modern Healthcare: Trends, Challenges, and Opportunities
Authors: Gasparovic Babic Svjetlana , Krsek Antea , Baticic Lara
Published: December 2024

Voluntary blood donation plays a crucial role in public health by ensuring a stable supply of blood and its components, essential for medical treatments including surgeries, trauma care, and chronic disease management. Voluntary donors, often healthier individuals, enhance the safety of the blood supply and play a vital role in emergency preparedness. Beyond its societal benefits, regular blood donation may offer health advantages for donors, including improved cardiovascular health due to reduced iron levels and psychological benefits stemming from altruism and a sense of social responsibility. Public health initiatives are instrumental in fostering blood donation through education, awareness campaigns, and targeted donor recruitment strategies. These efforts encourage a culture of social responsibility, inspiring community participation and improving overall healthcare system sustainability. Despite these efforts, challenges such as fluctuating donation rates, aging populations, and shifting demographics underscore the need for ongoing initiatives to ensure a sufficient blood supply. As a public health priority, voluntary blood donation demands continuous promotion and innovation to meet the growing demand for blood products and maintain healthcare system resilience. This review highlights the public health significance of voluntary blood donation, with particular focus on its benefits for donors and its role in supporting healthcare systems.
Effects of Fresh Corn Stover to Corn Flour Ratio on Fermentation Quality and Bacterial Community of Mixed Silage
Authors: Li Jintong , Wu Ke , Wu Jiaxuan , Yang Chuang , Sun Baoli , Deng Ming , Liu Dewu , Li Yaokun , Liu Guangbin , Guo Yongqing
Published: December 2024

Due to the high price of whole-plant corn silage in southern China, many dairy farms are attempting to prepare whole-plant corn silage using corn stover and corn flour, but the mixing ratio has not yet been determined. Therefore, we mixed fresh corn stover and corn flour at the proportions of 100:0 (F0 group) to 80:20 (F20 group), using five groups with three replicates each. The optimal mixing ratio was determined by assessing the nutritional composition, fermentation quality, and bacterial community of silage after 45 days. The results showed that dry matter and water-soluble carbohydrates in silage increased linearly with the increasing ratio of corn flour (p < 0.01) while crude protein, true protein, neutral detergent fiber, acidic detergent fiber, and crude ash content decreased linearly (p < 0.01). The F0 group had the highest pH, and the mixing ratio quadratically affected ammonia nitrogen concentration (p < 0.05). Additionally, at the phylum level, the relative abundances of Proteobacteria and Cyanobacteria in the F15 group were significantly higher than in other groups (p < 0.05). At the genus level, Lactobacillus increased with corn flour inclusion compared to the F0 group. In conclusion, the silage quality is the best when the mixing ratio of fresh corn stover and corn flour is 85:15.
Fire Behavior Characteristics and Computational Simulation Research on Historic Wooden Structures
Authors: Liu Tongshuang , Li Ang , Yao Min , Deng Jun , Huang Qianrui , Li Zheng , Li Haojia , Yi Xin
Published: December 2024

Wooden structures are prone to fire hazards, and studying their combustion properties is vital for their protection. Samples of fresh pine wood (FP) and pine subjected to artificially accelerated aging (treated at 240 circulation) were collected and prepared for analysis. The heat-release rate, smoke production, and yields of carbon monoxide (CO) and carbon dioxide (CO2) from both types of pine were assessed using conical calorimetry to determine their combustion characteristics. A historic building in Xi’an was modeled using PyroSim to serve as a representative case. The experimentally obtained combustion characteristics of the two pine wood types were inputted into the model, and the Fire Dynamics Simulator (FDS) software was utilized to simulate the development of fire in both newly constructed and aging historic buildings. The results suggest that aging impairs the wood’s combustion properties and increases the susceptibility of pine to ignition. Consequently, this accelerates the spread of fire in wooden structures, leading to a rapid increase in temperature and swift smoke production during fires, thus amplifying the fire risk to historic wooden buildings.
Loop-Mediated Isothermal Amplification-Based Workflow for the Detection and Serotyping of Salmonella spp. in Environmental Poultry Flock Samples
Authors: Regal Patricia , Doval Anne , García-Ramos Iria , Cepeda Alberto , Garrido-Maestu Alejandro , Lamas Alexandre
Published: December 2024

Salmonella spp. is one of the most important foodborne pathogens worldwide. Given the fact that poultry and poultry products are the main source of human infection, Salmonella control in these farms is of utmost importance. To better control this pathogen in farms, boot swabs are used to sample farm environments but the analysis of these swabs is mainly based on culture-dependent methods. In the present study, a novel loop-mediated isothermal amplification (LAMP) method was developed for the rapid screening of Salmonella spp. in boot swab samples from broiler flock environments. Four different DNA extraction protocols were evaluated in depth, including a simple thermal lysis, a chelex-based protocol and two thermal lysis protocols followed by the purification of magnetic beads made of silica (“glass milk”) in order to determine the most suitable alternative for potential on-site, farm analyses. The methodology evaluation included a blind interlaboratory assay and as a proof-of-concept, a naked-eye colorimetric assay was also included. Following the final methodology, it was possible to reach an LoD50 of 1.8 CFU/25 g of the samples, with a high relative sensitivity (95.7%), specificity (100%) and accuracy (96.6%) along with Cohen’s kappa of concordance with respect to the ISO standard 6579-1:2017 of 0.9, with an RLOD of 1.3. In addition to this, due to the relevance of certain serotypes with the genus Salmonella spp., a serotype LAMP panel for the specific identification of S. Typhimurium, S. Enteritidis, S. Infantis, S. Hadar and S. Virchow was also developed. Even though some degree of cross-reactivity among the primers developed was observed, all the serotypes could be accurately identified based on their melt curve analysis profile. Taken together, in the present study, a rapid Salmonella spp. screening method, suitable for farm applications, was developed, along with a serotyping panel that could be used in a laboratory setup for the identification of the most relevant serotypes of the genus, taking advantage of real-time amplification followed by melt curve analysis.
Garlic and Chitosan Improve the Microbial Quality of Hummus and Reduce Lipid Oxidation
Authors: Osaili Tareq M. , Al-Nabulsi Anas A. , Taybeh Asma’ O. , Olaimat Amin N. , Taha Sadi , Karam Layal , Ayyash Mutamed , Hasan Fayeza , Al Dabbas Maher M. , Bamigbade Gafar Babatunde , Al-Holy Murad , Savvaidis Ioannis N. , Obaid Reyad S. , Holley Richard
Published: December 2024

This study investigated the antimicrobial and antioxidant effects of garlic and chitosan on hummus. Hummus was prepared by using 0.5% or 1% (w/w) chitosan, with or without 1% (w/w) garlic, and samples were stored at 4, 10, or 25 °C for 28, 21, or 7 d, respectively. The behavior of lactic acid bacteria (LAB), Pseudomonas spp., aerobic bacteria, and yeasts and molds was then investigated. Color, pH, TBARS, and rheological properties were also measured. In hummus, both with and without garlic, chitosan added at 0.5% and 1% w/w significantly (p < 0.05) decreased LAB, aerobic bacteria, yeasts, and molds, and Pseudomonas spp., at 4 °C. However, at 10 °C, adding chitosan at 1% w/w significantly reduced only aerobic bacteria (2.2 log cfu/g) and Pseudomonas spp. (1.0 log cfu/g). The pH values (regardless of treatment) decreased upon storage. The addition of garlic or chitosan did not significantly affect the lightness (L*) or yellowness (b*). However, garlic, regardless of chitosan concentration, notably reduced lipid oxidation (0.8–1.4 MDA Eq/kg of sample) and had a greater impact on the sensory properties compared to chitosan. The results of this study will encourage producers to produce hummus that has a better flavor due to garlic with enhanced microbial quality.
Influence of Microbial Transglutaminase on the Formation of Physico-Chemical Properties of Meat Analogs
Authors: Zimoch-Korzycka Anna , Krawczyk Anna , Król-Kilińska Żaneta , Kulig Dominika , Bobak Łukasz , Jarmoluk Andrzej
Published: December 2024

With growing environmental and health concerns surrounding meat consumption, meat analogs have emerged as sustainable and health-conscious alternatives. A major challenge in developing these products is replicating the fibrous, elastic texture of meat, where microbial transglutaminase (MTG) has shown significant potential. MTG catalyzes protein cross-linking, enhancing the structural integrity of meat analogs. This study aimed to evaluate the effects of MTG concentrations (0%, 0.5%, and 1%) and incubation times (0, 1.5, and 3 h) on the quality and rheological properties of meat analogs. Analogs were tested for pH, protein content, dry matter, fat retention, and thermal loss. Textural properties, including hardness, cohesiveness, gumminess, springiness, and chewiness, were determined using texture profile analysis, while leakage parameters were evaluated through water and fat content tests. Results revealed that higher MTG concentrations and longer incubation times improved protein content (14.34% to 15.55%), dry matter (29.61% to 32.53%), and reduced total leakage (1.262% to 0.634%). Textural properties, including hardness (57.08 N to 83.14 N), gumminess (19.40 N to 30.00 N), and chewiness (17.60 N × mm to 29.58 N × mm), also significantly improved with increasing MTG levels. Thermal loss ranged from 98.37% to 100.9%, showing enhanced retention at higher MTG concentrations. These results support the role of MTG in creating meat analogs with improved meat-like textures, achieved through enhanced protein cross-linking and moisture retention.
Quality Characteristics and Flavor Analysis of Five Mulberry Varieties
Authors: Meng Yingmei , Lian Yinyin , Li Jiaxin , Suo Huayi , Song Jiajia , Wang Mei , Zhang Yu
Published: December 2024

For a deeper understanding of the characteristics exhibited by several novel mulberry varieties, the quality attributes and flavor components of five mulberry varieties (Zhongsang 5801, 2000-3, Jialing 40, Yuesang 10, and White Shahtoot Mulberry) were analyzed and compared. Zhongsang 5801 displayed the highest total phenol and flavone levels. Fructose and glucose were the primary sugars identified in the mulberries, with 2000-3 exhibiting the highest fructose content (39.66 ± 11.31 g/kg), whereas Zhongsang 5801 had the highest glucose content (26.19 ± 6.29 g/kg). The key organic acids found in the five mulberry varieties were oxalic acid, tartaric acid, and malic acid. Of them, 2000-3 had the highest malic acid content (0.66 ± 0.02 g/kg). Furthermore, 21 amino acids and 66 volatile components were detected in the five mulberry varieties. The study findings offer valuable insights for assessing, processing, and utilizing different mulberry varieties.
Fractal Dimensional Analysis of Building Facades: The Case of Office Buildings in Erbil City
Authors: Ali Lana Abubakr , Mustafa Faris Ali
Published: December 2024

Fractal dimension is a characteristic parameter used to measure the complexity and irregularity of geometric shapes and patterns. It is applied in architecture to explore complexity and irregularity and to assess the aesthetic preferences in architectural design. Office building facade design pattern, as an observation unit, has a positive connection with the aesthetic value. This study aims to evaluate facade design styles in terms of two aesthetic qualities, visual complexity and visual diversity, via applying fractal dimension to three design styles of office building facades in Erbil City. The study uses a combination of qualitative and quantitative evaluations to achieve this goal. It employs box-counting analysis through the ImageJ plugin to FracLac and the mathematical perplexity equation to evaluate visual complexity and diversity. The results indicate that the neo-classical office facade style, with a visual complexity value of 1.7008 and visual diversity of 21.27, presents an elevated level of aesthetics similar to the saccadic pattern facade. This study concluded that a neo-classical architectural style for office building facades is the most aesthetically preferable. Modern facade design is considered a secondary architectural style aimed at achieving aesthetic value. Ultimately, the high-tech style is the least attractive facade style. This study contributes to avoiding designs of unattractive office building facades due to a lack of architectural design vocabulary while avoiding overly complex designs that prove visually upsetting for viewers.
Lignin Polyurethane Aerogels: Influence of Solvent on Textural Properties
Authors: Altarabeen Razan , Rusakov Dmitri , Manke Erik , Gibowsky Lara , Schroeter Baldur , Liebner Falk , Smirnova Irina
Published: December 2024

This study explores the innovative potential of native lignin as a sustainable biopolyol for synthesizing polyurethane aerogels with variable microstructures, significant specific surface areas, and high mechanical stability. Three types of lignin—Organosolv, Aquasolv, and Soda lignin—were evaluated based on structural characteristics, Klason lignin content, and particle size, with Organosolv lignin being identified as the optimal candidate. The microstructure of lignin polyurethane samples was adjustable by solvent choice: Gelation in DMSO and pyridine, with high affinity to lignin, resulted in dense materials with low specific surface areas, while the use of the low-affinity solvent e.g acetone led to aggregated, macroporous materials due to microphase separation. Microstructural control was achieved by use of DMSO/acetone and pyridine/acetone solvent mixtures, which balanced gelation and phase separation to produce fine, homogeneous, mesoporous materials. Specifically, a 75% DMSO/acetone mixture yielded mechanically stable lignin polyurethane aerogels with a low envelope density of 0.49 g cm−3 and a specific surface area of ~300 m2 g−1. This study demonstrates a versatile approach to tailoring lignin polyurethane aerogels with adjustable textural and mechanical properties by simple adjustment of the solvent composition, highlighting the critical role of solvent–lignin interactions during gelation and offering a pathway to sustainable, high-performance materials.
Preparation and Characterization of Ultrasonically Modified Peanut Protein–Guar Gum Composite Emulsion Gels for 3D Printing
Authors: Yan Hong-Yan , Zhang Shao-Bing
Published: December 2024

This study aimed to prepare ultrasonically modified peanut protein–guar gum composite emulsion gels for 3D printing. The composition of the composite emulsion gels was determined in single-factor and orthogonal experiments. The results revealed that the optimal composite emulsion gels consisted of 6% peanut protein, 50% oil and 0.2% guar gum. After crushing pretreatment for 45 s, the printing deviation of the composite emulsion gels was reduced to 8.58 ± 0.20%. Moreover, after ultrasonic treatment (200 W for 20 min) of peanut proteins, the obtained composite emulsion gels presented the highest yield stress, hardness and G’ values, as well as a denser and more homogeneous microstructure. After protein ultrasonic modification (200 W or 600 W for 20 min), the printing accuracy and self-supporting properties of the composite emulsion gels for printing complex shapes significantly improved, which was attributed to their stronger textural and rheological properties; however, ultrasonically modified peanut protein–guar gum composite emulsion gels were not suitable for printing products with smooth surfaces.
Innovative Ink-Based 3D Hydrogel Bioprinted Formulations for Tissue Engineering Applications
Authors: Sousa Ana Catarina , Mcdermott Grace , Shields Fraser , Alvites Rui , Lopes Bruna , Sousa Patrícia , Moreira Alícia , Coelho André , Santos José Domingos , Atayde Luís , Alves Nuno , Richardson Stephen M. , Domingos Marco , Maurício Ana Colette
Published: December 2024

Three-dimensional (3D) models with improved biomimicry are essential to reduce animal experimentation and drive innovation in tissue engineering. In this study, we investigate the use of alginate-based materials as polymeric inks for 3D bioprinting of osteogenic models using human bone marrow stem/stromal cells (hBMSCs). A composite bioink incorporating alginate, nano-hydroxyapatite (nHA), type I collagen (Col) and hBMSCs was developed and for extrusion-based printing. Rheological tests performed on crosslinked hydrogels confirm the formation of solid-like structures, consistently indicating a superior storage modulus in relation to the loss modulus. The swelling behavior analysis showed that the addition of Col and nHA into an alginate matrix can enhance the swelling rate of the resulting composite hydrogels, which maximizes cell proliferation within the structure. The LIVE/DEAD assay outcomes demonstrate that the inclusion of nHA and Col did not detrimentally affect the viability of hBMSCs over seven days post-printing. PrestoBlueTM revealed a higher hBMSCs viability in the alginate-nHA-Col hydrogel compared to the remaining groups. Gene expression analysis revealed that alginate-nHA-col bioink favored a higher expression of osteogenic markers, including secreted phosphoprotein-1 (SPP1) and collagen type 1 alpha 2 chain (COL1A2) in hBMSCs after 14 days, indicating the pro-osteogenic differentiation potential of the hydrogel. This study demonstrates that the incorporation of nHA and Col into alginate enhances osteogenic potential and therefore provides a bioprinted model to systematically study osteogenesis and the early stages of tissue maturation in vitro.
Multi-Objective Distributionally Robust Optimization for Earthquake Shelter Planning Under Demand Uncertainties
Authors: Tang Kai , Osaragi Toshihiro
Published: December 2024

Deciding the locations of shelters and how to assign evacuees to these locations is crucial for effective disaster management. However, the inherent uncertainty in evacuation demand makes it challenging to make optimal decisions. Traditional stochastic or robust optimization models tend to be either too aggressive or overly conservative, failing to strike a balance between risk reduction and cost. In response to these challenges, this research proposes a multi-objective distributionally robust optimization (MODRO) model tailored for shelter location and evacuation allocation. First, an ambiguity set (moment-based or distance-based) is constructed to capture the uncertainty in evacuation demand, reflecting the possible range of outcomes based on demand data from a disaster simulation model. Then, the distributionally robust optimization model considers the “worst-case” distribution within this ambiguity set to minimize construction cost, travel distance, and unmet demand/unused capacity, balancing the trade-off between overly conservative and overly optimistic approaches. The model aims to ensure that shelters are optimally located and evacuees are efficiently allocated, even under the most challenging scenarios. Furthermore, Pareto optimal solutions are obtained using the augmented ε-constraint method. Finally, a case study of Ogu, a wooden density built-up area in Tokyo, Japan, compares the DRO model with stochastic and robust optimization models, demonstrating that the cost obtained by the DRO model is higher than a stochastic model while lower than the worst-case robust model, indicating a more balanced approach to managing uncertainty. This research provides a practical and effective framework for improving disaster preparedness and response, contributing to the resilience and safety of urban populations in earthquake-prone areas.
Transforming Heritage into Innovation Spaces: Exploration of Heritage Helix Ecosystems
Authors: Yildiz Gozde , Hetemoglu-Venedik Asli
Published: December 2024

Heritage has increasingly emerged as a pivotal medium for driving and adapting to change, and as an integral component of innovation ecosystems. In the ongoing participatory turn in governance, the management of collective heritage resources reflects a broader paradigm shift aimed at fostering sustainable socio-technical transformations. Far from being static relics of the past, heritage assets function as dynamic agents of innovation, thus influencing various dimensions of contemporary life. This research sheds light on heritage as a vibrant force for transformation and adjustment, showcasing its ability to position itself as a crucial component that both enables and guides broader processes of innovation. It emphasises how heritage sites, characterised by their transitional nature and ‘ex’ and ‘post’ identities, have become arenas for creative regeneration and socio-cultural, technical, territorial, and knowledge-based innovation. By utilising helical models and Schumpeter’s theory of creative destruction, this article underscores the transformative power of heritage to address global disruptions through heritage-driven innovations, drawing on three heritage and creative destruction categorizations. This highlights how heritage actively shapes innovative knowledge spaces while fostering urban and social regeneration, positioning it as a vital tool for rebuilding and reimagining sustainable futures. By exploring diverse local heritage transformation initiatives across different regions, this research unveils three heritage helix models that showcase the dynamic process of change management through heritage. These models offer a framework for guiding future heritage projects, fostering innovative knowledge spaces and inspiring sustainable transformations.
The Sacred Federation of Tibet and the Mongol Empire
Authors: Kong Lingkai
Published: December 2024

This article re-examines the history of the Mongol Empire’s rule over Tibet, analyzing the complex institutional and religious relationships between the Mongol Empire and Tibet from an innovative perspective. We find that, unlike its military conquests in other parts of the world, the Mongol Empire actually formed a kind of federation with Tibet based on Buddhism. The Mongol Empire embraced Tibetan Buddhism as its state religion and venerated the head of the Sakya school as a spiritual guide. Concurrently, the establishment of the Bureau of Buddhist and Tibetan Affairs in the Mongol capital served as a nominal governing body over Tibet, while in reality, it ensured a significant degree of autonomy for the region. Furthermore, the leaders of the Mongol Empire felt endowed with the legitimacy to conquer the world after being blessed by Tibetan Buddhism as Mahakala, the dark incarnation of Avalokiteshvara. In addition, the article also provides a detailed account of the prosperity of Buddhism within the Mongol Empire, in terms of its economic, artistic, and philosophical aspects. The discovery of this evidence is of great significance, since it not only supports reinterpretation of the historical evolution of the Mongol Empire and Tibet, but also allows us to observe the status of Tibetan Buddhism in the Mongol Empire from a new perspective, and to explore the unexpected institutional innovations of the federation reflected in the Mongol-Tibetan relationship.
Assessment of Contribution of Cover Crop Littering Decomposition to the N Uptake of Bearing and Non-Bearing Satsuma Mandarin Trees
Authors: Tassinari Adriele , Nogara de Siqueira Gustavo , Krug Amanda Veridiana , Morsch Letícia , Trapp Talita , Toselli Moreno , Baldi Elena , Brunetto Gustavo
Published: December 2024

Nitrogen (N) derived from the decomposition of litter from cover crops can contribute to the mineral nutrition of citrus trees. This study aimed to assess the prior contribution of N derived from the decomposition of forage radish (Raphanus sativus) and black oats (Avena strigosa) to Satsuma mandarin tree N demand. Forage radish and black oats were grown and enriched with 15N stable isotope. Two studies were conducted on (1) non-bearing, potted satsuma mandarin seedlings for 120 days in the greenhouse (Experiment 1) and (2) bearing field-growing Satsuma mandarin trees for 270 days (Experiment 2). Tree growth and total N and 15N concentrations were determined in annual and perennial organs of citrus and soil. The highest value of N derived from the decomposition of cover crop root residues was observed in the leaves and roots of non-bearing trees, while the highest amount of N derived from shoot residue decomposition was observed in the leaves of bearing trees. The results showed little contribution of the decomposition of residues of forage radish and black oats on the total N budget of annual and perennial organs of both bearing and non-bearing Satsuma mandarin trees, probably because the climatic conditions promoted a fast N mineralization and possible losses through volatilization and leaching.
Green Hydrogen Blending into the Tunisian Natural Gas Distributing System
Authors: Bdioui Hadhami , Touati Hazem , Ben Chiekh Maher , López-Agüera Angeles
Published: December 2024

It is likely that blending hydrogen into natural gas grids could contribute to economy-wide decarbonization while retaining some of the benefits that natural gas networks offer energy systems. Hydrogen injection into existing natural gas infrastructure is recognised as a key solution for energy storage during periods of low electricity demand or high variable renewable energy penetration. In this scenario, natural gas networks provide an energy vector parallel to the electricity grid, offering additional energy transmission capacity and inherent storage capabilities. By incorporating green hydrogen into the NG network, it becomes feasible to (i) address the current energy crisis, (ii) reduce the carbon intensity of the gas grid, and (iii) promote sector coupling through the utilisation of various renewable energy sources. This study gives an overview of various interchangeability indicators and investigates the permissible ratios for hydrogen blending with two types of natural gas distributed in Tunisia (ANG and MNG). Additionally, it examines the impact of hydrogen injection on energy content variation and various combustion parameters. It is confirmed by the data that ANG and MNG can withstand a maximum hydrogen blend of up to 20%. The article’s conclusion emphasises the significance of evaluating infrastructure and safety standards related to Tunisia’s natural gas network and suggests more experimental testing of the findings. This research marks a critical step towards unlocking the potential of green hydrogen in Tunisia.
Innovation Capacity as a Mediating Mechanism Between Strategic Risk Integration and ESG Performance: Evidence from Jordanian Banks
Authors: Al-Nimer Munther
Published: December 2024

While prior research has established direct relationships between strategic risk integration and ESG performance in banking, critical gaps remain in understanding the transformation mechanisms, particularly in emerging markets. This study investigated how banking innovation capacity mediates the relationship between strategic risk integration and ESG performance in Jordanian banks. Drawing on dynamic capabilities theory and questionnaire data from 165 banking executives (71.7% response rate), the results revealed that strategic risk integration significantly influences ESG performance both directly and indirectly through banking innovation capacity. The multi-group analysis showed institutional invariance between commercial and Islamic banks, suggesting the generalizability of these relationships. The findings advance dynamic capabilities theory by demonstrating innovation capacity’s role as a transformative mechanism in banking sustainability and provide practical insights for emerging market banks seeking to enhance ESG performance through integrated risk management and innovation strategies.
Molecular Detection of Lymph Node Metastases with One-Step Nucleic Acid Amplification (OSNA) Pooling in Prostate Cancer: The POPCORN Study
Authors: Cuadras Mercè , Semidey Maria E. , Planas Jacques , de Torres Inés M. , Regis Lucas , Celma Ana , Trilla Enrique , Ramón y Cajal Santiago , Medina Rafael A. , Congregado Belén , Marcilla David , Japón Miguel A. , Ramirez Miguel , Calatrava-Fons Ana , Leivar Asier , Alonso María B. , García Eugenia , González-Peramato Pilar , Vazquez-Martul Dario , Concha-López Ángel , Chantada Venancio , Queipo Francisco J. , Gago José L. , Carrato Cristina , Luque Rafael J. , Moreno-Jimenez Juan , Catalina-Fernández Inmaculada , León Cristina , Morote Juan
Published: December 2024

Pelvic lymph node dissection (PLND) is the most accurate procedure for lymph node (LN) staging in prostate cancer (PCa) patients. LN sectioning and hematoxylin and eosin (H&E) staining of at least one slice remains the gold standard for LN evaluation, potentially leading to misdetection of small metastatic focus. Entire LN analysis is possible with One-Step Nucleic Acid Amplification (OSNA) by detecting cytokeratin 19 (CK19) mRNA as a surrogate for LN invasion. This study aimed to compare postoperative performance of OSNA pooling with conventional H&E staining for pathological LN detection in PCa patients. POPCORN was an observational, prospective, and multicenter study of patients with PCa who underwent PLND. Dissected LNs were analyzed by both methods. This study included 2503 LNs from 131 patients, showing no statistically significant differences in pathological LN detection. Concordance between methods was high (93.9%), as were specificity (96.6%) and negative predictive value (96.6%) of OSNA pooling. The measure of agreement (Cohen’s Kappa [κ]) was 0.70. Only eight (6.1%) discordances were observed, including four misdetections from each method. Results showed a high concordance between OSNA pooling and H&E staining, suggesting that OSNA pooling may be a good alternative to H&E staining to detect LN metastases in PCa patients.
The Potential of Mesenchymal Stem Cell-Derived Exosomes in Cardiac Repair
Authors: Kundu Dipan , Shin Song Yi , Chilian William M. , Dong Feng
Published: December 2024

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and effectively repairing the heart following myocardial injuries remains a significant challenge. Research has increasingly shown that exosomes derived from mesenchymal stem cells (MSC-Exo) can ameliorate myocardial injuries and improve outcomes after such injuries. The therapeutic benefits of MSC-Exo are largely due to their capacity to deliver specific cargo, including microRNAs and proteins. MSC-Exo can modulate various signaling pathways and provide several beneficial effects, including cytoprotection, inflammation modulation, and angiogenesis promotion to help repair the damaged myocardium. In this review, we summarize the cardioprotective effects of MSC-Exo in myocardial injury, the underlying molecular mechanism involved in the process, and various approaches studied to enhance their efficacy based on recent findings.
Disulfidptosis and Its Hub Gene Slc3a2 Involved in Ulcerative Colitis Pathogenesis, Disease Progression, and Patient Responses to Biologic Therapies
Authors: Yang Qing-Qing , Guo Jun-An , Zhang Ke , Li Si-Hui , Xia Wan-Yu , Wang De-Xian , Xie Lu-Shuang , Wang Jun-Meng , Wu Qiao-Feng
Published: December 2024

To analyze the role of disulfidptosis in ulcerative colitis (UC), large-scale datasets combined with weighted gene co-expression network analysis (WGCNA) and machine learning were utilized and analyzed. When the hub genes that are associated with UC disease phenotypes and have predictive performance were identified, immune cell infiltration and the CeRNA network were constructed, the role of hub genes in UC pathogenies and biotherapy were investigated, and molecular docking studies and mice-verified tests were carried out to further explore the potential core genes and potential target. Finally, we found 21 DRGs involved in UC pathogenesis, including SLC3A2, FLNA, CAPZB, TLN1, RPN1, etc. Moreover, SLC3A2, TLN1, and RPN1 show a notable correlation with UC inflammatory state, and the expression of DRGs is closely related to the response to UC biotherapy. Our study suggests that disulfidptosis plays a crucial role in the pathogenesis and disease progression of UC. Higher expression of DRGs is commonly observed in moderate to severe UC patients, which may also affect their response to biologic therapies. Among the identified genes, SLC3A2 stands out, providing new insights into the underlying mechanisms of UC and potentially serving as a novel therapeutic target for the treatment of UC.
Circadian Effects of Melatonin Receptor-Targeting Molecules In Vitro
Authors: Chhe Kaitlyn , Hegde Maya S. , Taylor Stephanie R. , Farkas Michelle E.
Published: December 2024

Circadian rhythms are important for maintaining homeostasis, from regulating physiological activities (e.g., sleep–wake cycle and cognitive performance) to cellular processes (e.g., cell cycle and DNA damage repair). Melatonin is a key regulator of circadian rhythms and exerts control by binding to melatonin receptor 1 (MT1), decreasing neuronal firing in the suprachiasmatic nucleus (SCN). Previous work studying effects of melatonin on circadian rhythms utilized in vivo models. Since MT1 is also expressed outside of the brain, it is important to study impacts of melatonin on circadian gene oscillations in vitro. We evaluated the effects of melatonin and an MT1 inverse agonist, UCSF7447, in U2OS circadian reporter cell lines, which facilitate detailed assessments of oscillatory changes. We report that cellular circadian rhythms are responsive to treatment with MT1-targeting molecules; their activities are not dependent upon the SCN. Corroborating in vivo data, both melatonin and UCSF7447 lengthened the periods of BMAL1 and PER2, and while melatonin delayed circadian phases, UCSF7447 advanced them. Compounds were also dosed at two different times, however this did not yield changes. Our findings indicate the importance of utilizing in vitro models and that the direct effects of melatonin likely go beyond the SCN and should be explored further.
Leveraging Saliva for Insights into Head and Neck Cancer
Authors: Rashid Saad , Puttagunta Prashant , Pamulapati Saagar , Yang Jianqiang , Pocha Suneha , Saba Nabil F. , Teng Yong
Published: December 2024

Head and neck cancer (HNC) represents a heterogeneous group of malignancies with increasing global incidence and notable mortality. Early detection is essential for improving survival rates and minimizing recurrence; however, existing diagnostic methods are often invasive and complex. There is a need for noninvasive and more effective approaches for early detection and real-time monitoring of HNC. Saliva contains various biomolecules that may serve as indicators of HNC. As a result, saliva-based biomarkers have emerged as a transformative approach in the diagnosis and treatment of HNC due to their ease of collection, non-invasiveness, and potential to provide details about biomolecular changes associated with cancer progression. This narrative review synthesizes the current literature on the potential of saliva as a noninvasive diagnostic tool for HNC. It highlights various biomarkers found in saliva, including cell-free DNA, RNA, proteins, and metabolites, and explores emerging technologies in saliva detection that could transform the future of HNC management. Continued research efforts and larger-scale validation studies are essential to fully realize the potential of saliva-based biopsy and help pinpoint notable biomarkers to improve patient outcomes and reduce mortality associated with HNC worldwide.
Aortitis Increases the Risk of Surgical Complications and Re-Operations After Major Aortic Surgery
Authors: Staniforth Edward , Dubey Shirish , Ttofi Iakovos , Perinparajah Vanitha , Ttofi Jasmina , Vijjhalwar Rohit , Uberoi Raman , Sideso Ediri , Krasopoulos George
Published: December 2024

Aortitis, defined as inflammation of the aorta, can lead to aneurysms and dissections. Intra-operative sampling is essential for diagnosis, with many cases presenting asymptomatically as clinically isolated aortitis. Previous studies investigating aortitis in major aortic surgery have been limited by low intra-operative sampling. We performed an 11-year, retrospective, cross-sectional study to investigate the true prevalence of aortitis in thoracic aortic aneurysms and dissections by analysing all major aortic operations performed in a single centre. We collected medical histories, histological reports, post-operative outcomes and follow-up data; 537 patients met the inclusion criteria, representing an 88% histological sampling rate. The prevalence of aortitis was 10.6% (n = 57), of which 75% were clinically isolated. The re-operation rate in aortitis was twice that of non-aortitis patients (17.5% vs. 9.4%, p = 0.054). Multivariate logistic regression identified increased age, female sex, current smoking, and other inflammatory diseases as significantly associated with aortitis, with a bicuspid aortic valve associated with a significantly decreased likelihood of aortitis. The true prevalence of aortitis is likely higher than reported in previous studies, with our study showing twice the prevalence found in previous studies with lower sampling rates. Due to the increased re-intervention in aortitis, specialist multi-disciplinary follow-up and aortitis centres should be formed.