bluuebunny/crossref_metadata_2025 huggingface dataset:
3D-QSAR Studies on 4,5-Dihydro-1H-pyrazolo [4,3-h] Quinazolines as Plk-1, CDK2/A and Aur-A Serine/Threonine Kinase Inhibitors
Authors: Bhongade Bhoomendra A. , Amnerkar Nikhil D. , Gadad Andanappa K.
Published: June 2019

Background:

The family of serine/threonine protein kinases is associated with peculiar
tumor cell-cycle checkpoints which are overexpressed in proliferating tissues as well as in cancers,
making them as potential targets for cancer chemotherapy. In the present paper, 3D-QSAR studies
were carried out on 4,5-dihydro-1H-pyrazolo[4,3-h]quinazolines against serine/threonine protein
kinases viz. polo-like 1 (Plk-1), cyclin dependent 2/A (CDK2/A) and Aurora-A (Aur-A) and their in
vitro anti-proliferative activity on A2780 ovarian cancer cell line.

Methods:

3D-QSAR models were derived using stepwise forward-backward partial least square
(SWFB_PLS) regression method using VlifeMDS QSAR plus software and the docking calculations
were carried out using Docking Server.

Results:

The derived statistically significant and predictive 3D-QSAR models exhibited correlation
coefficient r2 in the range of 0.875 to 0.966 and predictive r2 in the range of 0.492 to 0.618. The hydrogen
bond donor NH group joining the phenyl ring with quinazoline and terminal amide group
were found to favored for Plk-1, CDK2/A and anti-proliferative activity. Estimated energy of binding
of compound 45 with enzymes was in the range of -8.52 to -9.03.

Conclusion:

The results of 3D-QSAR studies may be useful in the development of new pyrazolo[
4,3-h]quinazoline derivatives with better inhibitory activities against serine/threonine kinases.
Polymeric Nanoparticles: A Promising Tool to Enhance the Solubility of Poorly Water Soluble Drug
Authors: Kasekar Nirmal M. , Singh Sarabjit , Jadhav K.R. , Kadam V.J.
Published: June 2019

Objective:

The objective of this study was to entrap water-insoluble drug itraconazole
into polymer to form drug entrapped nanoparticles by using simple formulation strategy and characterize
them for various in vitro properties.

Method:

Itraconazole (ITZ) encapsulated Eudragit E 100 nanoparticles (IEENs) were formulated by
emulsification solvent evaporation technique.

Results:

Developed IEENs were evaluated for entrapment efficiency, particle size, polydispersity
index, and drug release profile. It was clear that drug polymer ratio along with homogenization
speed are the factors affecting droplet size of an emulsion. Evaluation was done by HPLC at
263nm. DSC, XRD studies were carried out. The in vitro antifungal study of nanoparticles suggested
that they are more effective in inhibiting growth of Candida albicans.

Conclusion:

The results from this study suggest the potential use of IEENs to provide a possible
way of improving solubility and thus oral absorption of Itraconazole. Thus the study concluded that
IEENs have potential to effectively treat the fungal infection.
The Usefulness of Serum Sorbitol and Vascular Endothelial Growth Factor A in Predicting Diabetic Retinopathy as Compared to Optical Coherence Tomography
Authors: Hama Almandlawi Sanaa Gadbaan , Mawlood Muhanad Salah
Published: June 2019

Background:

No specific and sufficient diagnostic biomarkers are currently available for predicting diabetic retinopathy (DR).

Objectives:

This study was conducted to investigate the validity of serum sorbitol and Vascular Endothelial Growth Factor A (VEGF-A) in diagnosing DR and differentiating it from diabetes without retinopathy (DNR). The study also investigated the diagnostic efficiency of these biomarkers when compared to optical coherence tomography OCT.

Methods:

A cross-sectional study included 164 diabetes mellitus patients: 30 patients with no retinopathy (the control group), 86 patients with non-proliferative diabetic retinopathy (NPDR), and 48 patients with Proliferative Diabetic Retinopathy (PDR). Patients were referred to the Layla Qasim Diabetic Center between November 2016 and October 2017 and an ophthalmologist established a DR diagnosis using OCT. Serum sorbitol and serum VEGF-A were measured for all patients.

Results:

By using study biomarkers, the cut-off values of VEGF-A (124.7 ng/ml) and sorbitol (0.3112 mg/ml) were established, and their validity parameters. For sorbitol, the values were as follows: specificity was 75.4, the sensitivity was 80 and 68.3% of observed agreement with the results of the OCT technique. For VEGF-A, the specificity was 73.1 the sensitivity was 80 and 76.2% of the observed agreement. The combined parallel test was applied as negative if both the tests were negative or as positive if either of the tests was positive: a highly significant statistical agreement (Kappa test p <0.001) was found with the gold standard diagnosis (OCT), with 85.4% of observed agreement.

Conclusion:

A combination of serum sorbitol and VEGF-A for diagnosing DR and for differentiating DR from DNR patients exhibits a significant agreement with an OCT diagnosis.
O mito da ausência de preconceito racial na educação infantil no Brasil
Authors: Marques Circe Mara , Dornelles Leni Vieira
Published: June 2019

Este artigo trata do preconceito racial na Educação Infantil. Resultou de uma pesquisa qualitativa, realizada em escolas infantis da região metropolitana de Porto Alegre, em 2013. Teve o propósito de investigar o modo como as culturas africanas são apresentadas às crianças de 0-3 anos no sentido de implantar o Art. 7º, inciso V, das Diretrizes CurricularesNacionais para a Educação Infantil (DCNEI). Segundo esse documento, as propostas pedagógicas devem estar comprometidas com o rompimento das relações de dominação diversas, inclusive étnico-racial. A coleta de dados ocorreu através de observações e conversas com gestores e professores que atuam em escolas infantis. Os resultados mostraram que a maioria dos profissionais desconhece as DCNEI. Estes afirmaram que nãoocorrem problemas raciais na Educação Infantil e justificaram que as crianças de 0-3 anos são pequenas e não percebem tais diferenças. Praticamente, não há materiais didáticos e imagens de pessoas negras nos espaços das escolas pesquisadas. É preciso não só dar visibilidade às crianças de 0-3 anos como também desconstruir o mito da ausência de preconceito racial para que as histórias e culturas africanas adentrem nos tempos e espaços destas escolas.

Palavras-chave: Educação Infantil; Diretrizes CurricularesNacionais para a Educação Infantil; Preconceito racial
O Exílio dos Professores Brasileiros em Portugal e a Documentação da DOPS-PR
Authors: Braggio Ana Karine , Fiuza Alexandre Felipe
Published: June 2019

Este artigo almeja analisar a experiência vivida por professores brasileiros que se exilaram para garantir sua sobrevivência, ameaçada por perseguições ocorridas no período da ditadura civil-militar brasileira (1964-1985). Nosso enfoque se direciona aos indivíduos citados nos dossiês temáticos do acervo da Delegacia de Ordem Política e Social do Estado do Paraná (DOPS/PR) e que se exilaram em Portugal. Entre os 2.378 dossiês da DOPS/PR catalogados, analisamos os oito dossiês que tratam especificamente do exílio de brasileiros. Nestes materiais, rastreamos os nomes dos exilados que foram professores no Brasil e/ou que atuaram na docência em Portugal. Nosso objetivo é apresentar, como uma parte da história do exílio, a história de alguns destes professores, que, apesar das dificuldades de adaptação a uma nova cultura e de vivência em novos espaços sociais e políticos, afastados de amigos e familiares, assumiram relevo na consolidação e circulação de novos ideais no plano político-ideológico. Contribuíram ainda para o desenvolvimento pedagógico, utilizando como referência, ainda que esporádica, a Pedagogia Libertadora do movimento educacional crítico e emancipatório sob influência de Paulo Freire, que, por sua militância política incompatível com os anseios do governo ditatorial, também vivenciou a experiência do exílio.

 Palavras-Chave: Exílio; Militância; Docência; Ditadura.
Escala de Atribuições de Causalidade e Rendimento Escolar: Estudo de Evidência de Validade de Critério
Authors: Ferraz Adriana Satico , Santos Acácia Angeli dos , Almeida Leandro da Silva
Published: June 2019

O objetivo deste estudo foi conferir a evidência de validade de critério concorrente para a Escala de Avaliação das Atribuições de Causalidade para Alunos do Ensino Fundamental (EAVAT-EF), tendo como variável critério o rendimento escolar. Considerou-se como medida de rendimento as classificações dos alunos em Língua Portuguesa e Matemática e a sua autopercepção de rendimento na escola. Participaram 661 alunos de escolas públicas brasileiras do Ensino Fundamental I e II (3.º ao 9.º ano), de ambos os gêneros, com idades entre 8 e 17 anos (M= 11.82; DP= 1.91). O modelo de predição do rendimento escolar constituiu-se pelos fatores da EAVAT-EF acrescido às variáveis gênero, número de repetências e autopercepção de rendimento, e foi testado nos dois ciclos do Ensino Fundamental. Este modelo funcionou apenas para o Ensino Fundamental II. No Ensino Fundamental I, por meio da análise de regressão linear, os fatores da EAVAT-EF tiveram a variância explicada menos expressiva para o rendimento escolar em comparação aos coeficientes padronizados identificados no Ensino Fundamental II. Considera-se que as atribuições de causalidade têm impacto no rendimento escolar avaliado por meio das classificações e da autopercepção de rendimento dos alunos, e vice-versa. Os resultados sugerem, ainda, que este impacto se consolida, tornando-se cada vez mais relevante com o avançar na escolaridade.

Palavras-chave:Atribuição causal; Motivação para a aprendizagem; Ensino Básico; Avaliação psicoeducacional
Entre a fralda e a lousa: A questão das identidades docentes em berçários
Authors: Oliveira Rosmari Pereira de , Viviani Luciana Maria
Published: June 2019

Neste artigo apresentamos uma pesquisa sobre identidades docentes em berçários desenvolvida em um Centro de Educação Infantil na cidade de São Paulo (Brasil). Mediante enfoque qualitativo e multidisciplinar, o estudo buscou tecer relações entre identidade, cultura, gênero e poder, aproximando a área dos estudos culturais ao campo da educação infantil. Inspirado em abordagens biográficas, o estudo empírico foi realizado através de entrevistas com sete professoras e um professor de educação infantil, que atuavam com crianças de 0 a 2 anos de idade. As análises indicaram que, embora a prática nos berçários envolvesse múltiplos saberes e culturas, produzia-se nos discursos dos professores um binarismo sobre a necessidade de cuidar e educar em que cuidar associava-se às práticas do passado e educar aproximava-se ao seu novo papel profissional, representando estratégias identitárias para valorizar a docência com bebês.

Palavras-chave: Identidades docentes; Educação infantil; Culturas institucionais
Dieta low carb como estratégia de manejo na remissão do diabetes mellitus insulinorresistente: síntese de evidências
Authors: Sessa Wagner , Ferraz Renato Ribeiro Nogueira
Published: June 2019

Introdução: O DM tipo II está associado à deficiência no funcionamento de determinados mecanismos responsáveis pela regulação da sensibilidade tecidual à ação da insulina, em concomitância à secreção deficiente do hormônio pelas células beta pancreáticas. As dietas LC restringem os carboidratos diários para algo entre 20 e 50g, mostrando associação com uma considerável perda de peso. Todavia, os efeitos da dieta LC no controle do DM II são bastante controversos. Objetivo: Realizar uma revisão da literatura englobando ensaios clínicos que comprovadamente testaram os efeitos da dieta LC na remissão do DM II. Método: Para seleção dos trabalhos foi utilizada a seguinte estratégia de busca: (low-carb OR "low carb" OR “low carbohydrate” OR low-carbohydrate OR ketogenic OR Atkins) AND (diabetes OR diabetics) AND (type-2 OR "type 2" OR type-II OR "type II" OR "insulinresistant") AND "clinical trial", na base de dados PUBMED/MEDLINE. Resultados: Foram revisados 12 artigos que preencheram os critérios de inclusão. Síntese de Evidências: A dieta LC melhora o equilíbrio glicêmico, devendo ser considerada em pacientes portadores de DM tipo II e que necessitam de suporte nutricional. A referida dieta ainda reduz a gordura visceral, melhora a sensibilidade à insulina e aumenta os níveis de HDL. A estabilidade da glicemia diurna e do perfil lipídico podem ser mantidos com a dieta LC, sem efeitos adversos renais, e sem a necessidade de medicamentos hipoglicemiantes. A dieta é bem tolerada e se mostra bastante segura, mesmo quando prescrita em longo prazo.
Reduced Hospitalizations, Emergency Room Visits, and Costs Associated with a Web-Based Health Literacy, Aligned-Incentive Intervention: Mixed Methods Study (Preprint)
Authors: Greene Jeffrey C , Haun Jolie N , French Dustin D , Chambers Susan L , Roswell Robert H
Published: June 2019

BACKGROUND

The association between health literacy and health care costs, particularly for hospitalizations and emergency room services, has been previously observed. Health information interventions aimed at addressing the negative impacts of inadequate health literacy are needed. The MedEncentive Mutual Accountability and Information Therapy (MAIT) Program is a Web-based system designed to improve health and lower costs by aligning patient-doctor incentives.

OBJECTIVE

In this mixed methods study of a Web-based patient-doctor aligned-incentive, information therapy program conducted in an 1800-member employee health plan, we aimed to (1) determine the program’s quantitative impact on hospitalization and emergency room utilization and costs, and (2) assess survey responses about the program’s perceived value.

METHODS

We used a mixed methods, single within-group, pre-post, descriptive study design. We analyzed quantitative data using pre-post mean utilization and cost differences and summarized the data using descriptive statistics. We used open-ended electronic survey items to collect descriptive data and analyzed them using thematic content analysis.

RESULTS

Hospitalizations and emergency room visits per 1000 decreased 32% (26.5/82.4) and 14% (31.3/219.9), respectively, after we implemented the program in 2015-2017, relative to 2013-2014. Correspondingly, the plan’s annual per capita expenditures declined US $675 (95% CI US $470-865), or 10.8% ($675/$6260), after program implementation in 2015-2017 (US $5585 in 2013-2014 dollars), relative to the baseline years of 2013-2014 (US $6260; P<.05). Qualitative findings suggested that respondents valued the program, benefiting from its educational and motivational aspects to better self-manage their health.

CONCLUSIONS

Analyses suggested that the reported reductions in hospitalizations, emergency room visits, and costs were associated with the program. Qualitative findings indicated that targeted users perceived value in participating in the MAIT Program. Further research with controls is needed to confirm these outcomes and more completely understand the health improvement and cost-containment capabilities of this Web-based health information, patient-doctor, aligned-incentive program.
Train Wrecks
Authors: Strean William Ben
Published: June 2019

We all fail. We also like to look good and avoid looking bad.  So, even though we know that taking risks and trying new approaches are important for enhancing our teaching and students’ learning (Strean, 2017), we rarely talk about our failures. Our claim in this paper is that our insecurities create a substantial barrier to improving and enriching our teaching practices.  If we do not find time to take big risks, and then to explore and critically reflect on failures that result sometimes from those risks, we lose out on the chance to become better teachers; more fundamentally, we deprive our students of the chance to have extraordinary opportunities to learn.

 

Nous connaissons tous des échecs. Or, nous voulons projeter une image positive de nous-mêmes. Ainsi, même si nous savons qu’il est important de prendre des risques et d’essayer de nouvelles approches pour améliorer notre enseignement ainsi que l’apprentissage de nos étudiants (Strean, 2017), il est rare que nous parlions de nos échecs. Dans cet article, nous avançons l’idée suivante : notre manque d’assurance constitue un obstacle considérable à l’amélioration et à l’enrichissement de nos pratiques d’enseignement. Si nous ne nous donnons pas du temps pour prendre des risques importants, puis pour réfléchir de manière critique sur les échecs qui découlent parfois de cette prise de risque, nous laissons passer une occasion de nous améliorer en tant qu’enseignants. Qui plus est, nous privons ainsi nos étudiants d’occasions d’apprentissage exceptionnelles.
From Perception to Practice
Authors: Shaw Lindsay , Brown Kristin , Ellis Donna , Wolf Peter , Dawson Debra , Goff Lori , Kustra Erika
Published: June 2019

Teaching culture is the product of a dynamic interplay among the embedded patterns, behaviours, values, beliefs and ideologies about teaching and learning within and across the many microcultures that make up a university. Educational researchers from across Canada developed a set of Institutional Teaching Culture Perception Surveys (ITCPS) to gain insight to an institution’s teaching culture at a particular point in time. Staff, faculty, and students from two institutions provided comments through an open-ended survey and focus groups, answering the question “What would indicate to you that teaching matters at your institution?” Aligning with the six ITCPS levers, the results identified both barriers and pathways to a strong institutional teaching culture, highlighting strategic priorities, assessment methods, effective pedagogy, supportive infrastructure, engagement opportunities and public recognition.

 

La culture d’enseignement est le fruit d’une interaction dynamique entre les habitudes, les comportements, les valeurs, les croyances et les idéologies portant sur l’enseignement et sur l’apprentissage à travers les multiples microcultures qui composent une université. Des chercheurs en éducation de partout au Canada ont mis au point un sondage – appelé ITCPS – sur la perception de la culture d’enseignement afin de mieux comprendre une telle culture dans un établissement donné à un moment précis. Des employés, des enseignants et des étudiants provenant de deux établissements ont formulé des commentaires dans un sondage à questions ouvertes et dans des groupes de discussion. Ils ont répondu à la question suivante : « Qu’est-ce qui vous ferait penser que l’on accorde une valeur à l’enseignement dans votre établissement? » En adéquation avec les six mécanismes du sondage ITCPS, les résultats ont mis en évidence les obstacles et les voies à suivre pour atteindre à une culture d’enseignement forte en établissement, en soulignant les priorités stratégiques, les méthodes d’évaluation, la pédagogie efficace, l’infrastructure de soutien, les possibilités de participation et la reconnaissance publique.
Inquire, Imagine, Innovate: A Scholarly Approach to Curriculum Practice
Authors: Yeo Michelle , Boman Jennifer , Mooney Julie , Phillipson Andrea , Da Rosa dos Santos Luciano , Smith Erika
Published: June 2019

This paper describes the development of a three-phase approach our team of educational developers finds useful in curriculum projects in our Teaching and Learning Centre. Informed by the literature on the importance of flexibility and iteration (Knight, 2001; Wolf, 2007) and an orientation towards Appreciative Inquiry (Srivastra & Cooperrider, 1990), we contextualize our work in relation to others in the Canadian educational development landscape. Additionally, we highlight the importance of recognizing micro, meso, and macro levels of influence in institutions of higher education (Poole & Simmons, 2013). We describe our Inquire, Imagine, and Innovate, or 3-I, model for curriculum consultation, positioned by fictionalized vignettes demonstrating how each phase is applied. We conclude the paper by indicating where we are continuing to develop this work.

 

Dans cet article, nous décrivons l’élaboration d’une approche en trois phases que notre équipe de concepteurs pédagogiques juge utile pour les programmes de notre centre d’enseignement et d’apprentissage. À partir de la recherche sur l’importance de la flexibilité et l’itération (Knight, 2001; Wolf, 2007) et d’un penchant pour l’interrogation appréciative (Srivastva et Cooperrider, 1990), nous replaçons notre recherche dans le contexte d’autres travaux dans le domaine du perfectionnement de l’enseignement au Canada. De plus, nous insistons sur l’importance de reconnaître les micro-, macro- et méso-niveaux d’influence dans les établissements d’enseignement supérieur (Poole et Simmons, 2013). Nous décrivons notre modèle 3-I – Interrogation, Imagination, Innovation – pour la consultation sur les programmes, en montrant, au moyen de fictions sur vignettes, comment chaque phrase se déroule. En conclusion, nous indiquons quelles sont les suites que nous donnons à ce travail.
Adapting Curriculum for a Changing Context
Authors: Reid Robin Elizabeth
Published: June 2019

Changing demographics at post-secondary institutions in Canada provide opportunities for intercultural learning. Curricular design that engages domestic and international students can result in new ways of knowing, seeing, and understanding multiple perspectives of and connections to place. This paper draws on students’ reflections to highlight the effectiveness of place-based and intercultural pedagogies in cultivating a deeper understanding of multiple perspectives of local landscapes, including those of indigenous, non-indigenous, domestic and international students. This is particularly relevant to the study of tourism, an inherently place- based discipline.

 

L’évolution des caractéristiques démographiques dans les établissements postsecondaires du Canada représente l’occasion d’un apprentissage interculturel. Le design curriculaire qui inclut la participation des étudiants canadiens et étrangers peut susciter de nouvelles façons de connaître, d’observer et de comprendre les perspectives multiples et les relations au lieu. Le présent article puise dans les réflexions des étudiants pour souligner l’efficacité des pédagogies interculturelles axées sur la dimension locale en approfondissant la compréhension des perspectives multiples et des paysages locaux, y compris les paysages des Autochtones, des non-Autochtones et des étudiants canadiens et étrangers. Voilà qui est tout particulièrement pertinent pour l’étude du tourisme, un domaine d’études intrinsèquement lié au lieu.
Product reputation mining: bring informative review summaries to producers and consumers
Authors: Piao Zhehua , Park Sang-Min , On Byung-Won , Choi Gyu , Park Myong-Soon
Published: June 2019

Product reputation mining systems can help customers make their buying decision about a product of interest. In addition, it will be helpful to investigate the preferences of recently released products made by enterprises. Unlike the conventional manual survey, it will give us quick survey results on a low cost budget. In this article, we propose a novel product reputation mining approach based on three dimensional points of view that are word, sentence, and aspect?levels. Given a target product, the aspect?level method assigns the sentences of a review document to the desired aspects. The sentence?level method is a graph-based model for quantifying the importance of sentences. The word?level method computes both importance and sentiment orientation of words. Aggregating these scores, the proposed approach measures the reputation tendency and preferred intensity and selects top-k informative review documents about the product. To validate the proposed method, we experimented with review documents relevant with K5 in Kia motors. Our experimental results show that our method is more helpful than the existing lexicon?based approach in the empirical and statistical studies.
How much topological structure is preserved by graph embeddings?
Authors: Liu Xin , Zhuang Chenyi , Murata Tsuyoshi , Kim Kyoung-Sook , Kertkeidkachorn Natthawut
Published: June 2019

Graph embedding aims at learning representations of nodes in a low dimensional vector space. Good embeddings should preserve the graph topological structure. To study how much such structure can be preserved, we propose evaluation methods from four aspects: 1) How well the graph can be reconstructed based on the embeddings, 2) The divergence of the original link distribution and the embedding-derived distribution, 3) The consistency of communities discovered from the graph and embeddings, and 4) To what extent we can employ embeddings to facilitate link prediction. We find that it is insufficient to rely on the embeddings to reconstruct the original graph, to discover communities, and to predict links at a high precision. Thus, the embeddings by the state-of-the-art approaches can only preserve part of the topological structure.
Automated two-phase business model-driven synthesis of conceptual database models
Authors: Brdjanin Drazen , Banjac Danijela , Banjac Goran , Maric Slavko
Published: June 2019

Existing approaches to business process model-driven synthesis of data models are characterized by a direct synthesis of a target model based on source models represented by concrete notations, where the synthesis is supported by monolithic (semi)automatic transformation programs. This article presents an approach to automated two-phase business process model-driven synthesis of conceptual database models. It is based on the introduction of a domain specific language (DSL) as an intermediate layer between different source notations and the target notation, which splits the synthesis into two phases: (i) automatic extraction of specific concepts from the source model and their DSL-based representation, and (ii) automated generation of the target model based on the DSL-based representation of the extracted concepts. The proposed approach enables development of modular transformation tools for automatic synthesis of the target model based on business process models represented by different concrete notations. In this article we present an online generator, which implements the proposed approach. The generator is implemented as a web-based, service-oriented tool, which enables automatic generation of the initial conceptual database model represented by the UML class diagram, based on business models represented by two concrete notations.
Logical filter approach for early stage cyber-attack detection
Authors: Jusas Vacius , Japertas Saulius , Baksys Tautvydas , Bhandari Sandeepak
Published: June 2019

The planned in advance cyber-attacks cause the most damage for the users of the information systems. Such attacks can take a very long time, require considerable financial and human resources, and therefore, they can only be organized by large interest groups. Furthermore, current intrusion detection systems, intrusion prevention systems and intrusion response systems used to protect against cyber-attacks have several shortcomings. Such systems respond only to the attack itself when it is too late to take a preventive action and they are not suitable for detecting an attack in early stages when it is possible to block the attack and minimize the losses. Early detection requires detailed monitoring of network and system parameters to be able to accurately identify the early stages of the attack when it is still possible to kill the attack chain. In this paper, we propose to consider an attack chain consisting of nine stages. The method to detect early stage cyberattack based on the attack chain analysis using hardware implementation of logical filters is suggested. The performed experiment acknowledges the possibility to detect the attack in the early stages.
Association of Serum Retinol-Binding Protein 4 Levels and the Risk of Incident Type 2 Diabetes in Subjects With Prediabetes
Authors: Fan Jiahua , Yin Songping , Lin Diaozhu , Liu Yangqing , Chen Nixuan , Bai Xinxiu , Ke Qiuyi , Shen Jia , You Lili , Lin Xiuhong , Li Feng , He Fengyi , Yan Li , Chen Chaogang , Xia Min
Published: June 2019

OBJECTIVE

To explore the association of serum retinol-binding protein 4 (RBP4) levels and risk for the development of type 2 diabetes in individuals with prediabetes.

RESEARCH DESIGN AND METHODS

A population-based prospective study was conducted among 1,011 Chinese participants with prediabetes (average age 55.6 ± 7.2 years). Incident type 2 diabetes was diagnosed according to the American Diabetes Association 2010 criteria. Serum RBP4 levels were measured using a commercially available ELISA. We analyzed the association of serum RBP4 levels with the risk of incident type 2 diabetes using the Cox proportional hazards model.

RESULTS

During a median follow-up period of 3.1 years, 153 participants developed incident type 2 diabetes. A U-shaped association was observed between serum RBP4 levels and the risk of incident type 2 diabetes, with the lowest risk in the RBP4 range of 31–55 μg/mL. Multivariate Cox regression model analysis showed that serum RBP4 levels <31 μg/mL and RBP4 levels >55 μg/mL were associated with an increased risk of incident type 2 diabetes. The adjusted hazard ratios (95% CI) were 2.01 (1.31–3.09) and 1.97 (1.32–2.93), respectively, after adjusting for age, sex, BMI, waist circumference, γ-glutamyltransferase, HOMA of insulin resistance index, fasting plasma glucose, 2-h plasma glucose, and glycated hemoglobin (HbA1c) levels.

CONCLUSIONS

A U-shaped relationship exists between serum RBP4 levels and the risk of incident type 2 diabetes in subjects with prediabetes.
Immunohistochemical Analysis of Nerve Distribution in Mandible of Rats
Authors: Kudo Kanae , Tanaka Katsunori , Ambe Kimiharu , Kawaai Hiroyoshi , Yamazaki Shinya
Published: June 2019

After review of the literature, there appears to be no report on the histology of the mandibular nerve fiber distribution. Therefore, using a Wistar rat model, immunohistochemical staining with protein gene product (PGP) and calcitonin gene-related peptide (CGRP) antibody for all nerves and only the pain-sensitive nerves, respectively, was performed. We also statistically compared the nerve distribution density by mandibular region. The section of the mandible from the alveolar crest to the mandibular canal was compartmentalized to several regions. Subsequently, nerve distribution density by region was measured microscopically in both the PGP- and CGRP-positive nerves. Furthermore, the ratio of CGRP- to PGP-positive nerves was measured in each region and statistically compared. In both the PGP- and CGRP-positive nerves, the nerve distribution density significantly increased vertically toward the mandibular canal from the alveolar crest and horizontally toward the periodontal ligament from the periosteum. From the CGRP- to PGP-positive nerve ratio, the pain-sensitive nerve accounted for approximately >70% in each region. Pain would therefore be more likely to develop when surgical invasiveness deepens toward the mandibular canal or periodontal ligament. Therefore, sufficient local anesthetic infiltration and/or combined use of conduction anesthesia or periodontal ligament injection may be required. These results may aid in the development of more effective surgical and anesthetic techniques for mandibular surgery.
Esimiehen ja työntekijän vuorovaikutussuhde – heijastumia muuttuvaan työelämään
Authors: Forsten-Astikainen Riitta , Kultalahti Susanna
Published: June 2019

Työelämässä meneillään oleva murros edellyttää ihmisiltä yhä enemmän vuorovaikutustaitoja; työt pirstaloituvat (silpputyö) ja siirtyvät verkostoihin, digitalisoituminen, monimuotoistuminen monikulttuurisuuden ja uusien työntekijäsukupolvien myötä ja entinen osaaminen kohtaavat huomattavia muutospaineita. Erityisesti esimiehillä on merkittävä rooli, ja heidän vuorovaikutuskyvykkyytensä on avaintekijä muutoksissa, arjen sujumisessa, tuottavuuden ja työmotivaation ylläpidossa sekä työyhteisön työhyvinvoinnin ja työilmapiirin kehittymisessä.Artikkelissa tutkitaan eri työntekijäryhmien kokemuksia vuorovaikutussuhteesta esimiehen kanssa sekä suhteen vaikutuksia työn imuun, yksilön ja yksikön osaamiseen ja yksikön suoriutumiseen sekä joustavuuteen. Tutkimuksen perustana on LMX-teoriaan pohjautuva käsitys esimiehen ja alaisen välisestä suhteesta. Aineisto on kerätty 4500 vastaajalta 93 pk-yrityksestä eri toimialoilta Suomessa ja analysoitu kvantitatiivisesti. Tutkimus liittyy Vaasan yliopiston ja Lappeenrannan teknillisen yliopiston 2015-2016 toteuttamaan HERMES-projektiin.Tutkimuksen keskeisin havainto liittyy työsuhteen tyyppiin ja työntekijän kokemukseen vuorovaikutuksen tasosta. Määräaikaisessa työsuhteessa olevat työntekijät arvioivat vuorovaikutuksen esimiehen kanssa parhaimmaksi verrattuna vakituisessa ja vuokratyösuhteessa oleviin. Löydös on yllättävä, ja kertoo vuorovaikutussuhteen merkityksellisyydestä ja uniikista kokemisesta. Vuorovaikutussuhteet erosivat myös sukupuolen ja esimiesaseman suhteen ja työntekijän asema vaikutti vuorovaikutussuhteen kokemisessa.
Kognitionsverb i sverigesvenska och finlandssvenska handledningssamtal
Authors: Nelson Marie , Henricson Sofie
Published: June 2019

I denna studie undersöker vi vilka kognitionsverb sverigesvenska och finlandssvenska studenter och handledare använder i akademiska handledningssamtal och i vilken omfattning de olika verben används. Materialet består av svenskspråkiga ämnes- och språkhandledningssamtal som spelats in vid universitet och högskolor i Sverige och i Finland. Resultatet av den kvantitativa och kontrastiva analysen visar att antalet och andelen kognitionsverb är högre i det sverigesvenska materialet. I båda materialsamlingarna använder handledarna fler kognitionsverb än studenterna. De finlandssvenska studenterna bidrar dock med fler kognitionsverb än de sverigesvenska studenterna. I analysen noteras vissa nyansskillnader vad gäller vilka semantiska fält som betonas och förekomsten av specifika kognitionsverb.
PENGEMBANGAN BAHAN AJAR BERBASIS KONTEKS SOSIOKULTURAL KOTA CIREBON DALAM PEMAHAMAN MATEMATIKA SISWA
Authors: Ilmiah Dede Malikhatul , Winarso Widodo
Published: June 2019

Penelitian ini bertujuan untuk menghasilkan bahan ajar berbasis konteks sosiokultural kota Cirebon yang memiliki kualitas yang baik dan layak. Bahan ajar dapat digunakan dalam pemahaman matematika siswa di MTs Riyadlul Ulum Bendungan. Jenis bahan ajar yang dikembangkan yakni bahan ajar cetak berbentuk modul matematika untuk kelas 7. Metode penelitian yang digunakan yaitu Research and Development yang mengacu pada model pengembangan ADDIE. Dimana langkah pengembangan yang dilakukan terdiri dari: 1) Analysis, 2) Design, 3) Development, 4) Implementation, 5) Evaluation. Teknik pengumpulan data yang digunakan dalam penelitian diantaranya; lembar vaidasi ahli (Expert Judgment), angket, dan tes. Sedangkan untuk analisis data mengunakan analisis kualitatif dan kuantitatif. Dari hasil penelitian, pengembangan bahan ajar berbasis konteks sosiokultural kota Cirebon dalam pemahaman matematika siswa termasuk kategori baik untuk dipakai dalam proses pembelajaran matematika. Hal tersebut, sejalan dengan hasil respon siswa terhadap bahan ajar yang dikembangkan tergolong baik. Pada hasil ujicoba terbatas maupun ujicoba keluasan, pengebangan bahan ajar mempuni diketiga aspek penilain (penilaian tampilan, penyajian materi, dan manfaat). Begitu juga hasil validasi tim ahli materi maupun media, bahwa bahan ajar yang dikembangkan termasuk kategori layak untuk digunakan dalam kegiatan pembelajaran. sehingga bahan ajar tersebut, sebagai pelengkap guru dalam mengajar dan dapat membantu siswa dalam memahami matematika dengan mengedepankan local wisdom-kota cirebon
IMPLEMENTASI METODE KARIMAH DALAM PEMBELAJARAN MEMBACA AL-QURâ€™AN DI PUSAT PENDIDIKAN AL-QURâ€™AN (PPQ) AL MAHIR, COLOMADU, KARANGANYAR
Authors: Widiani Desti Widiani
Published: June 2019

Kemampuan tilawah mayoritas umat Islam masih lemah. Hal ini terlihat masih seringnya terjadi kesalahan khaffi maupun jalli ketika membaca ayat suci Al-Qurâ€™an saat berpidato, berkhotbah atau ketika menjadi imam dalam shalat jamaah. Banyak faktor penyebab keadaan ini, dan terutama faktor yang terpenting adalah metode pengajaran yang kurang manhaji. Secara umum, metode-metode dalam pembelajaran Al-Qurâ€™an yang ada dewasa ini belum dapat memberikan solusi alternatif kepada pembelajar pemula untuk belajar membaca Al-Qurâ€™an secara mudah, praktis, sistematis, dan sesuai dengan kaidah ilmu tajwid. Karimah sebagai salah satu metode membaca Al-Qurâ€™an yang diterapkan di pusat pendidikan Al-Qurâ€™an Al Mahir Colomadu Karanganyar merupakan salah satu metode alternatif untuk membantu para pemula yang ingin membaca Al-Qurâ€™an secara mudah, praktis, sistematis, dan sesuai dengan kaidah ilmu tajwid. Tujuan penelitian ini adalah untuk mengetahui implementasi metode Karimah dalam pembelajaran Al-Qurâ€™an di Pusat Pendidikan Al-Qurâ€™an (PPQ) Al Mahir Colomadu Karanganyar. Hasil penelitian ini adalah implementasi pembelajaran membaca Al-Qurâ€™an di Pusat Pendidikan Al-Qurâ€™an (PPQ) Al-Mahir Colomadu Karanganyar mudah, praktis, sistematis, dan sesuai dengan kaidah ilmu tajwid. Implementasi metode Karimah diawali dengan pembukaan, kultum, pengajaran membaca Al Qurâ€™an dan penutup. Pengajaran membaca Al Quâ€™an dengan metode Karimah ini dibagi menjadi 3 tahap yaitu pemula, pra tahsin dan tahsin.
STRATEGI KEPALA SEKOLAH UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA DALAM MENGHADAPI UN DI SMP NEGERI 4 YOGYAKARTA
Authors: Faizah Faizah , Fauzan Ahmad
Published: June 2019

Tujuan dari penelitian ini, untuk mengetahui strategi kepala SMP Negeri 4 Yogyakarta guna meningkatkan motivasi belajar siswa dalam menghadapi Ujian Nasional (UN) setelah dua tahun mengalami penurunan. Menggunakan metode deskriptif kualitatif penelitian ini bertujuan untuk mendeskripsikan bentuk strategi kepala sekolah, faktor pendukung dan penghambat serta implikasi. Bentuk strategi kepala sekolah, di antaranya: (1) kerjasama dengan wali siswa, guru dan kepala sekolah; (2) kegiatan training motivasi; (3) inovasi pembelajaran; (4) menjadi leader, supervisor dan manajer; dan (5) menganjurkan siswa memiliki buku referensi belajar. Faktor pendukung dan penghambat berasal dari kepala sekolah, guru, siswa, wali siswa dan lingkungan. Hasil dari implikasi strategi kepala sekolah, yaitu: (1) motivasi siswa mengikuti bimbingan belajar bertambah, (2) siswa menjadi aktif di dalam kelas, (3) motivasi belajar siswa meningkat; dan (4) hasil UN lebih baik dari tahun sebelumnya.

Kata kunci : Strategi kepala sekolah, motivasi belajar siswa, ujian nasional.
PENDIDIKAN KELUARGA PERSPEKTIF HADIS NABI MUHAMMAD SAW
Authors: Nurhadi Nurhadi
Published: June 2019

Abstrak : Tokoh pendidikan yang paling berhasil dan sangat layak dijadikan tauladan dalam pendidikan keluarga Islam adalah Rasullullah saw. Penelitian ini bertujuan untuk mengetahui fungsi dan tanggung jawab kepala keluarga dalam mendidik anggota keluarganya menurut hadis Nabi Muhammad saw. Penelitianini model penelitian library research dengan menggunakan dua data, primer dan sekunder. Data primernya kitab hadis Sembilan (kutub al-Tisâ€™ah), data sekundernya sebagai pendukung, misalnya kitab syarah dari kitab tersebut. Teknik pengumpulan data menggunakan metode Tharq al-Hadis (metode menemukan hadis), dengan teknik analisisnya menggunakan contents analisys. Hasilnya bahwa Fungsi dan Tanggung Jawab Suami Mendidik Keluarga Perspektif Nabi Muhammad Saw dalam Kitab Hadis Kutub Al-Tisâ€™ah,adalah: 1). Fungsi dan Tanggung Jawab Suami dalam Mendidik Istri : Suami Pemimpin Keluarga, Kewajiban Mendidik Keluarga, Kewajiban Mendidik Istri, Mengajarkan Istri Al-Qurâ€™an, Mengajarkan Mandi Wajib, Mengajarkan Doa Kepada Istri, Mengajarkan Cara Meminta Belanja (Nafkah), Mendidik Tentang Bilangan Bulan, Mendidik Istri dengan Tegas dan Bijaksana, Kewajiban Mengajarkan Akhlak pada Istri, Kewajiban Mengajarkan Al-Qurâ€™an jika sebagai Mahar, Mengajak Istri Shalat Malam dan Mendidik Istri dengan Kasih Sayang. 2). Fungsi dan Tanggung Jawab Suami sebagai Orang Tua dalam Mendidik Anak-Anaknya : Kedua Orang Tua adalah Pemimpin, Nasehat Orang Tua Kepada Anak Perempuanya, Mengajarkan Al-Qurâ€™an Kepada Anak-Anaknya, Menikahi Janda Agar Menidik Anak-Anaknya, Mengajari Anak Baca Tulis, Mengajarkan Azan, Mengajarkan Shalat, Mengajarkan Hapalan Doa Mengajarkan Puasa, Mendidik Anak Laki-laki dan Perempuan, Mendoakan Anak, Mengajarkan Olah Raga, Mengajarkan Skill.

 

Kata Kunci: Pendidikan, Keluarga, Perspektif, Hadis, Nabi
PENGEMBANGAN KURIKULUM DI SD ISLAM AL AZHAR 38 BANTUL YOGYAKARTA
Authors: Sekarinasih Anggitiyas
Published: June 2019

Abstract:  Curriculum is a set of plans and arrangements that contain objectives, content, and lesson materials and used as guidelines for the implementation of learning activities so that the learning process can run smoothly. The current 2013 curriculum is defined as a national curriculum, which means all schools are required to use it. However, schools are allowed to develop the curriculum to suit their needs. SDI Al Azhar 38 Bantul is one of the primary schools in Yogyakarta that has developed a curriculum in its education. Al Azhar School uses a mixed curriculum of the national curriculum and curriculum from Al Azhar Central Foundation which is then supplemented with a curriculum of development from school and local potential. Curriculum of Al Azhar is called the Kurikulum Pengembangan Pribadi Muslim (KPPM). KPPM curriculum aims to hone akhlakul karimah in students. In addition Al Azhar 38 Bantul also has a curriculum Education Al Qur'an is an additional curriculum to optimize the ability of children in reading the Qur'an. This curriculum consists of reading material of the Qur'an and recitation juz 30.

Keywords: Curriculum Development, Al Azhar
PERBEDAAN PENGARUH METODE PEMBELAJARAN DAN KOORDINASI MATA TANGAN TERHADAP HASIL PEMBELAJARAN LAY-UP SHOOT PADA MAHASISWA PKO FIK UNIMED
Authors: Wiyaka Ibrahim , Hasibuan Muhammad Nustan , Manik Syahputra
Published: June 2019

Tujuan dari penelitian ini adalah untuk mengetahui: (l). Perbedaan dalam efek dari metode belajar kaki terikat dan kaki ganda terikat pada hasil belajar lay-up shoot. (2) Perbedaan pengaruh antara koordinasi mata-tinggi dan koordinasi mata-tangan rendah pada hasil belajar dari lay-up shoot. (3) Mengetahui apakah ada interaksi antara metode pembelajaran dan koordinasi mata-tangan dari hasil pembelajaran lay-up shoot. Penelitian menggunakan metode eksperimental. Desain penelitian ini adalah Faktorial 2 x 2. Populasi dari penelitian ini adalah semua siswa PKO FIK Unimed yang mengambil mata kuliah bola basket lanjutan. Sampel sebanyak 70 orang diambil dengan teknik total sampling. Instrumen penelitian menggunakan tes koordinasi mata-tangan dan tes lay-up shoot. Teknik analisis data menggunakan analisis statistik sedangkan perhitungan menggunakan uji beda dengan eksperimen Anova Factorial 2 x 2 pada tingkat signifikan 5%. Hasil penelitian menunjukkan (1). Ada perbedaan efek antara metode belajar kaki terikat dan kaki ganda terikat pada hasil belajar lay-up shoot. (2) Ada perbedaan dalam efek koordinasi tangan-mata tinggi dan koordinasi mata-tangan yang rendah pada hasil pembelajaran lay-up shoot, dan, (3). Ada interaksi antara metode pembelajaran dengan koordinasi mata-tangan pada hasil pembelajaran lay-up shoot.
HUBUNGAN STANDING BROAD JUMP DAN LARI SPRINT 20 METER TERHADAP HASIL KEMAMPUAN LOMPAT JAUH PADA SISWA KELAS XI SMA XAVERIUS II KOTA JAMBI
Authors: Indrayana Boy , Dasar Sukendro
Published: June 2019

Tujuan penelitian ini adalah untuk mengetahui hubungan standing broad jump dan lari sprint 20 meter terhadap hasil kemampuan lompat jauh Pada Siswa Kelas XI SMA Negeri Xaverius II Kota Jambi. Eksperimen Penelitian ini dilaksanakan di SMA Negeri Xaverius II Kota Jambi, Penelitian ini merupakan penelitian korelasional, yang hendak menyelidiki ada tidaknya hubungan antara variabel bebas dengan variabel terikat. Hasil analisis dengan menggunakan rumus (n-2) 40–2 = 38 pada α = 0,05, maka dengan dk 38, untuk uji dua pihak t 0,95 = 1,6860 mudah dilihat bahwa   4.214699687 >  1,6860  maka terdapat hubungan antara standing broad jump dengan kemampuan lompat jauh.   12.6050466 >  1,6860  maka terdapat hubungan antara lari sprint 20 meter dengan kemampuan lompat jauh.    3.361082 >  1,6860  maka terdapat hubungan antara standing broad jump dan lari sprint 20 meter. Dari perhitungan hasil analisis data antara standing broad jump dan  lari sprint 20 meter terhadap kemampuan lompat jauh  diketahui             r Hitung= 0.911273. Kemudian data tersebut diuji signifikansi korelasi dengan dibandingkan rtabel pada taraf signifikansi 5% = 0,312 yang berarti rhitung  > rtabel. Dengan demikian dapat disimpulkan terdapat hubungan standing broad jump dan lari sprint 20 meter terhadap hasil kemampuan lompat jauh pada siswa kelas XI SMA Xaverius Kota Jambi.
PENINGKATAN HASIL BELAJAR MATERI DRIBBLING SEPAK BOLA MELALUI PENDEKATAN BERMAIN
Authors: Pulungan Fahrijal , Bangun Sabaruddin Yunis
Published: June 2019

Penelitian ini bertujuan untuk mengetahui kemampuan dribbling dalam materi permainan Sepak bola melalui pendekatan bermain terhadap siswa kelas XI MAN 2 Model Medan Tahun 2017. Lokasi penelitian ini dilaksanakan di MAN 2 Model Medan. Subjek penelitian ini siswa Kelas XI IPS MAN 2 Model, dan sebagai objek penelitian seluruh siswa kelas XI IPS 4 berjumlah 30 orang siswa. Penelitian ini menggunakan metode Penelitian Tindakan kelas (PTK) dengan pendekatan kuantitatif melalui pendekatan bermain, untuk meningkatkan hasil belajar dribbling materi permainan sepak bola. Instrumen yang digunakan dalam penelitian adalah lembar fortofolio penilaian hasil belajar dribbling permainan sepak bola. Dari hasil data awal (pre test) dan observasi siswa yang tuntas saat melakukan dribbling adalah 7 orang (22,58%) sedangkan jumlah siswa belum tuntas sebanyak 23 orang (77,42%). Hasil penelitian pada: Hasil belajar siklus I diperoleh sebanyak 14 orang siswa (45.16%) telah mencapai tingkat ketuntasan belajar sedangkan 16 orang siswa (54.84%) belum mencapai tingkat ketuntasan belajar, persentase nilai rata-rata 63.41%. Namun belum memenuhi kriteria ketuntasan secara klasikal yang diharapkan yaitu 80%. Kemudian hasil belajar dilanjutkan pada siklus II diperoleh data sebanyak 26 orang siswa (87,09%) yang telah mencapai ketuntasan dalam belajar dan 4 orang siswa (12,91%) masih belum tuntas. Persentase nilai rata-rata 81.2%, peningkatan persentase nilai rata-rata hasil belajar siswa dari tes sebelumnya yaitu 12.15% dan peningkatan ketuntasan klasikalnya sebesar 10%. Penelitian ini menyimpulkan penggunaan metode pendekatan bermain dapat memberikan konstribusi yang sangat besar dan signifikan terhadap hasil belajar dribbling pada materi sepak bola.
PENGEMBANGAN BAHAN AJAR SENAM DASAR MODEL HYBRID LEARNING BERBASIS KKNI
Authors: Sitepu Indra Darma , Nasution Muhammad Faisal Ansari , Ibrahim Ibrahim
Published: June 2019

Inovasi dalam pendidikan saat ini semakin berkembang, dimana penggunaan teknologi komunikasi dan informasi dalam bidang pendidikan menjadi suatu tantangan bagi para pendidik dalam proses belajar mengajar. Penelitian ini bertujuan menghasilkan produk bahan ajar mata kuliah senam dasar model hybrid learning yaitu mengkombinasikan bahan ajar dalam bentuk cetak dan e-learning berbasis KKNI. Diharapkan pemanfaatan teknologi komunikasi dan informasi dalam proses pembelajaran melalui produk ini pada akhirnya dapat memecahkan masalah minimnya sumber belajar mata kuliah senam dasar dan peningkatan kualitas proses belajar mengajar pada mahasiswa jurusan PKO Fakultas Ilmu Keolahragaan terlebih dengan diterapkannya kurikulum KKNI saat ini. Implikasi dari produk tersebut akan memudahkan dosen dalam pelaksanaan pembelajaran yang sesuai dengan tuntutan kurikulum KKNI. Penelitian ini menggunakan metode research and development (R&D). Adapun subyek dalam penelitian ini adalah mahasiswa semester I jurusan Pendidikan Kepelatihan Olahraga FIK Unimed yang mengambil mata kuliah senam dasar. Penelitian yang dilakukan hingga saat ini telah melalui tahapan: analisis kebutuhan, perumusan tujuan, penyusunan naskah, evaluasi dan revisi I, ujicoba kelompok kecil, revisi II, dan uji coba kelompok besar. Dari tahapan tersebut dihasilkan produk berupa Rencana Pembelajaran Semester mata kuliah senam dasar berbasis KKNI dan produk bahan ajar senam dasar model hybrid learning berbasis KKNI.