bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal additional voluntary contribution in DC pension schemes to manage inadequacy risk
Authors: Ferreira Morici Henrique , Vigna Elena
Published: May 2024

In defined contribution pension schemes the member bears the investment risk and her main concern is to obtain an inadequate fund at retirement. To address inadequacy risk, flexibility is often given to the member to pay additional voluntary contributions (AVCs) into the fund. In many countries the AVC schemes allow members of the workplace pension plan to increase the amount of retirement benefits by paying extra contributions. In this paper, we define a target-based optimization problem where the member of an AVC scheme can choose at any time the investment strategy and the AVCs to the fund. In setting the problem, the member faces a trade-off between the importance given to the stability of payments during the accumulation phase and the achievement of the desired annuity at retirement. We derive closed-form solutions via dynamic programming and prove that (i) the optimal fund never reaches the target final fund, (ii) the optimal amount invested in the risky asset is positive, and (iii) the optimal AVC is higher than the target one. We run numerical simulations to allow for different member’s preferences, and perform sensitivity analyses to assess the controls’ robustness.
Integrating AI-driven threat intelligence and forecasting in the cyber security exercise content generation lifecycle
Authors: Zacharis Alexandros , Katos Vasilios , Patsakis Constantinos
Published: May 2024

The escalating complexity and impact of cyber threats require organisations to rehearse responses to cyber-attacks by routinely conducting cyber security exercises. However, the effectiveness of these exercises is limited by the exercise planners’ ability to replicate real-world scenarios in a timely manner that is, most importantly, tailored to the training audience and sector impacted. To address this issue, we propose the integration of AI-driven sectorial threat intelligence and forecasting to identify emerging and relevant threats and anticipate their impact in different industries. By incorporating such automated analysis and forecasting into the design of cyber security exercises, organisations can simulate real-world scenarios more accurately and assess their ability to respond to emerging threats. Fundamentally, our approach enhances the effectiveness of cyber security exercises by tailoring the scenarios to reflect the threats that are more relevant and imminent to the sector of the targeted organisation, thereby enhancing its preparedness for cyber attacks. To assess the efficacy of our forecasting methodology, we conducted a survey with domain experts and report their feedback and evaluation of the proposed methodology.
Mast cells in human choroid and their role in age-related macular degeneration (AMD)
Authors: Ribatti Domenico , Dammacco Rosanna
Published: May 2024

The role of mast cells in physiologic and pathological processes extends far beyond the allergy processes: they are involved in wound healing, chronic inflammation, and tumor growth. This short article emphasizes the role played by mast cells in age-related macular degeneration (AMD). Mast cells can induce angiogenesis and are present around Bruch's membrane during the early and late stages of choroidal neovascularization in AMD. Proteolytic enzymes released by mast cells lead to thinning of the choroid in AMD as well as degradation of vascular basement membranes and Bruch's membrane, which in turn could result in retinal pigment epithelial death and choriocapillaris degeneration in geographical atrophy and exudative AMD.
The influence of face mask color on perceptions of African American and white men
Authors: Morris Lauren A. , Bazzini Doris G. , Holden Christopher J. , Lee Savannah J.
Published: May 2024

Despite their widespread use during the COVID-19 pandemic, face masks hinder abilities to interpret facial expressions. Yet, they can also reduce the appearance of characteristics that are used to categorize individuals into racial groups, such as Afrocentric features. The color of a face mask might also promote associations with certain types of behavior and professional occupations (e.g., blue surgical mask connoting physician stereotypes; black masks potentially being associated with criminality). This study assessed whether the presence and color of a face mask impacted perceptions of a target male of varying race. White participants (N = 250) were presented with an African American or White male adult face from the Chicago Face Database (of equal age and attractiveness) wearing a blue or black surgical mask, or no mask (Photoshopped onto the face) and rated the man on emotions (happy, sad, angry) as well as how trustworthy, threatening, and attractive the target appeared. Targets wearing a blue surgical mask were judged as more trustworthy and attractive than those wearing no mask (perhaps due to association with medical professions), but these judgements were not qualified by race, despite the African American target’s selection based on Afrocentric features. The color black on a face mask did not exacerbate negative perceptions of targets, perhaps suggesting a decline effect in previously demonstrated associations between this color and criminal actions. Unlike previous research performed at the beginning of the Covid-19 Pandemic on cloth masks shown to potentially exacerbate racial biases, surgical masks (pleated and made of polymeric materials), appear to lessen potential stereotyping of Black relative to White men.
Comparing the effectiveness of adulticide application interventions on mitigating local transmission of dengue virus
Authors: Kummer Allisandra G. , Wilke André B. B. , Ventura Paulo C. , Vasquez Chalmers , Medina Johana , Unlu Isik , Gonzalez Yaziri , Mhlanga Adquate , Benelli Giovanni , Ejima Keisuke , Mutebi John-Paul , Ajelli Marco
Published: May 2024

The southern US has a large presence of mosquito vector species for dengue virus (DENV) and experiences thousands of DENV importations every year, which have led to several local outbreaks. Adulticide spraying targeting active mosquitoes is one of the most common insecticide strategies used as a response to an outbreak. The aim of this study is to evaluate the effectiveness of adulticide spraying conducted at different times of the day to curb DENV transmission. Based on unique dataset of Aedes aegypti diel activity patterns in Miami-Dade County, Florida, and Brownsville, Texas, we developed a mechanistic model of DENV transmission, which simulates adulticide spraying interventions. We estimated that spraying adulticide for 14 consecutive days at 7am or 8 pm was highly effective in reducing DENV outbreak probability from 10% in the absence of interventions to 0.1% for Miami-Dade County, and from 7.8 to 0.1% for Brownsville. Moreover, in case of a local outbreak in Miami-Dade County, we estimated the median number of symptomatic infections after the identification of a local outbreak to be reduced from 67.0 (IQR: 25.5–103.0) in the absence of interventions to 1.0 (IQR: 0.0–2.0) when spraying adulticide for 14 consecutive days at 8 pm. In Brownsville, the same intervention is estimated to lead to a decrease from 15.0 (IQR: 7.0–33.0) cases to 1.0 (IQR: 0.0–2.0). Our study highlights the importance of considering diel activity patterns of vector mosquito species in arbovirus preparedness and response planning and provide quantitative evidence to guide the decision-making of mosquito control authorities.
The all-pairs vitality-maximization (VIMAX) problem
Authors: Paul Alice , Martonosi Susan E.
Published: May 2024

Traditional network interdiction problems focus on removing vertices or edges from a network so as to disconnect or lengthen paths in the network; network diversion problems seek to remove vertices or edges to reroute flow through a designated critical vertex or edge. We introduce the all-pairs vitality maximization problem (VIMAX), in which vertex deletion attempts to maximize the amount of flow passing through a critical vertex, measured as the all-pairs vitality of the vertex. The assumption in this problem is that in a network for which the structure is known but the physical locations of vertices may not be known (e.g., a social network), locating a person or asset of interest might require the ability to detect a sufficient amount of flow (e.g., communications or financial transactions) passing through the corresponding vertex in the network. We formulate VIMAX as a mixed integer program, and show that it is NP-Hard. We compare the performance of the MIP and a simulated annealing heuristic on both real and simulated data sets and highlight the potential increase in vitality of key vertices that can be attained by subset removal. We also present graph theoretic results that can be used to narrow the set of vertices to consider for removal.
Biomarkers of mussel exposure to Vibrionaceae: A review
Authors: Azizan Awanis , Venter Leonie , Alfaro Andrea C.
Published: May 2024

For more than a century, bacterial infections caused by Vibrio spp. have affected various species of mussels around the world, with limited insights into the responses implemented by mussels against these infections. A combination of chemical analyses and carefully selected biological endpoints from haemolymph and tissues can be used to identify the welfare status of mussels and potentially protect aquatic ecosystems from catastrophic health threats. Recent developments in biomarker identification tools, such as omics and bioinformatics, have been successfully applied to evaluate the effect of environmental pollutants and other chemicals on mussels. However, the application of biomarkers to assess mussel health is limited. This review describes the available scientific literature on biomarker research for Vibrio-mussel interactions, and those aspects related to mussel health and disease assessment, grouped as biomarkers of exposure, effects, and susceptibility. From the review, it is clear that when integrated biomarkers are used, they can provide a deeper understanding of the relative health and potential susceptibility of mussels for better management practices. Furthermore, health biomarker data can be used to build resilience in mussels against climate change conditions, strengthen biosecurity management programs, improve farming and processing efficiency, and add value in terms of market-desirable traits. These data hold promise for advancing sustainability efforts within the aquaculture industry.

Graphical abstract
Current axillary management of patients with early breast cancer and low-volume nodal disease undergoing primary surgery: results of a United Kingdom national practice survey
Authors: Fairhurst K. , McIntosh S. A. , Cutress R. I. , Potter S. ,   Our Citable Collaborators, Abbott Nick , Abdullah Mohammad , Agrawal Avi , Arthur Laura , Bouhelal Amina , Bright-Thomas Rachel , Brown Victoria , Butt Sundas , Chan Charlie , Cheah Wilson , Chrysafi Adamantia , Clark Sarah , Cutress Ramsey , Donigiewicz Urszula , Dunlop Hannah , Egbeare Donna , Fahmy Waleed , Ferguson Douglas , Gill Nina , Glassman Daniel , Graja Tomasz , Gomez Kelvin Francis , Goyal Amit , Hamad Ahmed , Hargreaves Anita , Harris Grant , Hubbard Thomas , Humphreys Alex , Iqbal Javeria , Kalakouti Eliana , Kallaway Charlotte , Karat Isabella , Karim Sabeeha , Khawaja Saira , King Polly , Kleidi Eleftheria , Knight Hannah , Krupa Jaroslaw , Leeper Alexander , Lefemine Valentina , Lewis Rebecca , Linforth Richard , MacInnes Emma , Mactier Mhairi , Mamareli Christina , Masannat Yazan , Masudi Tahir , McLean Ross , Milligan Rob , Mohabadian Bijan Ansari , Morgan Jenna , Munir Asma , Murphy Claire , Nayak Soudamini , Ogston Keith , Price Robert , Pervaz Mujahid , Ramzi Saed , Rattay Tim , Regan Azel , Romics Laszlo , Rutherford Claire Louise , Saha Sunita , Sallam Ibrahim , Seth Subodh , Sheehan Lisa , Thorne Amanda , Vidya Raghavan , Williams Kate , Youssef Mina , Zafar Shaista
Published: May 2024

Purpose

UK NICE guidelines recommend axillary node clearance (ANC) should be performed in all patients with biopsy-proven node-positive breast cancer having primary surgery. There is, however, increasing evidence such extensive surgery may not always be necessary. Targeted axillary dissection (TAD) may be an effective alternative in patients with low-volume nodal disease who are clinically node negative (cN0) but have abnormal nodes detected radiologically. This survey aimed to explore current management of this group to inform feasibility of a future trial.

Methods

An online survey was developed to explore current UK management of patients with low-volume axillary disease and attitudes to a future trial. The survey was distributed via breast surgery professional associations and social media from September to November 2022. One survey was completed per unit and simple descriptive statistics used to summarise the results.

Results

51 UK breast units completed the survey of whom 78.5% (n = 40) reported performing ANC for all patients with biopsy-proven axillary nodal disease having primary surgery. Only 15.7% of units currently performed TAD either routinely (n = 6, 11.8%) or selectively (n = 2, 3.9%). There was significant uncertainty (83.7%, n = 36/43) about the optimal surgical management of these patients. Two-thirds (n = 27/42) of units felt an RCT comparing TAD and ANC would be feasible.

Conclusions

ANC remains standard of care for patients with low-volume node-positive breast cancer having primary surgery in the UK, but considerable uncertainty exists regarding optimal management of this group. This survey suggests an RCT comparing the outcomes of TAD and ANC may be feasible.
Undisruptable or stable concepts: can we design concepts that can avoid conceptual disruption, normative critique, and counterexamples?
Authors: Lundgren Björn
Published: May 2024

It has been argued that our concepts can be disrupted or challenged by technology or normative concerns, which raises the question of whether we can create, design, engineer, or define more robust concepts that avoid counterexamples and conceptual challenges that can lead to conceptual disruption. In this paper, it is argued that we can. This argument is presented through a case study of a definition in the technological domain.
Pattern Diversity Based Four-Element Dual-band MIMO Patch Antenna for 5G mmWave Communication Networks
Authors: Sethi Waleed Tariq , Kiani Saad Hassan , Munir Mehre E. , Sehrai Daniyal Ali , savci Huseyin şerif , Awan Dawar
Published: May 2024

This study presents a planar dual-band multiple-input multiple-output (MIMO) antenna design for the prospective fifth-generation (5G) frequency bands of 28 and 38 GHz. The antenna element is designed by utilizing a rectangular patch with an offset microstrip feeding technique. A dual-band response is achieved by placing semi-circular slots on each side of the patch element. To tune the frequency response and improve impedance matching, vertical rectangular slits are etched in the rectangular patch and the ground plane, respectively. The results show that the single antenna element offers an impedance bandwidth of 2.52 GHz (26.32–28.84 GHz) and 7.5 GHz (34–41.5 GHz). In addition, a MIMO configuration based on pattern diversity using four antenna elements is designed and fabricated. The designed MIMO configuration achieves an impedance bandwidth of 3 GHz (27–30 GHz) and 5.46 GHz (35.54–41 GHz) at operating bands of 28 and 38 GHz. The peak realized gain for the single element at 28 and 38 GHz is noted to be 7.4 dBi and 7.5 dBi, respectively. Furthermore, the polarization diversity configuration illustrates an isolation of > 15 dB and > 25 dB for the 28 and 38 GHz frequency bands, respectively. Moreover, the MIMO configuration attains appropriate values for the envelope correlation coefficient (ECC) and diversity gain (DG), Total Active Reflection Co-efficient (TARC), Channel Capacity Loss (CCL) and Mean Effective Gain (MEG) for the operating frequency bands. The proposed MIMO system based on results seems to be potential choice for mmwave Ka Band Applications.
Effect of polymer concentration and cross-linking density on the microstructure and properties of polyimide aerogels
Authors: Filimonova Ekaterina , Bergmann Thomas , Zhao Shanyu , Dyatlov Valery A. , Malfait Wim J. , Wu Tingting
Published: May 2024

Polyimide aerogels display excellent mechanical strength, high thermal stability, low thermal conductivity, and outstanding dielectric properties. Typically, the synthesis of polyimide aerogels involves the polycondensation of dianhydride and diamine into poly(amic acid) (PAA) oligomers, which are then cross-linked and chemically imidized into polyimide. The stoichiometry of dianhydride and diamine determines the number of repeat units and length of the PAA oligomers, which in turn determines the cross-linking density. Despite the critical role of polymer concentration and number of repeating units in determining the microstructure and properties of polyimide aerogels, few detailed studies exist on these two parameters. Here, we synthesized and characterized 16 polyimide aerogel formulations from the common monomers biphenyl-3,3′,4,4′-tetracarboxylic dianhydride (BPDA) and 4,4′-oxydianiline (ODA), with different repeat units (n = 5, 15, 30, 45) and total polymer concentrations (4, 7, 10, 13 wt%). An increased polymer concentration accelerated gelation and enhanced the mechanical performance of aerogels, but surprisingly, it also led to higher volumetric shrinkage during aging, solvent exchange, and supercritical drying (SCD). Specific surface areas (SSAs) reached a maximum at intermediate polymer concentrations. A shorter oligomer chain length, i.e., a higher cross-linking density, led to moderately higher SSAs (between 320 and 400 m2/g) and reduced shrinkage, resulting in lower densities for a given polymer concentration. The density dependence of the thermal conductivity exhibits a pronounced U-shaped curve with a minimum in thermal conductivity of 21–23 mW/(m·K) between 0.080 and 0.120 g/cm3, with somewhat lower values for more highly cross-linked aerogels. This systematic study of polyimide aerogels forms the basis for designing polyimide aerogels with tailored properties for targeted applications.

Graphical Abstract
The CRZ1 transcription factor in plant fungi: regulation mechanism and impact on pathogenesis
Authors: Cacciotti A. , Beccaccioli M. , Reverberi M.
Published: May 2024

Calcium (Ca2+) is a universal signaling molecule that is tightly regulated, and a fleeting elevation in cytosolic concentration triggers a signal cascade within the cell, which is crucial for several processes such as growth, tolerance to stress conditions, and virulence in fungi. The link between calcium and calcium-dependent gene regulation in cells relies on the transcription factor Calcineurin-Responsive Zinc finger 1 (CRZ1). The direct regulation of approximately 300 genes in different stress pathways makes it a hot topic in host-pathogen interactions. Notably, CRZ1 can modulate several pathways and orchestrate cellular responses to different types of environmental insults such as osmotic stress, oxidative stress, and membrane disruptors. It is our belief that CRZ1 provides the means for tightly modulating and synchronizing several pathways allowing pathogenic fungi to install into the apoplast and eventually penetrate plant cells (i.e., ROS, antimicrobials, and quick pH variation). This review discusses the structure, function, regulation of CRZ1 in fungal physiology and its role in plant pathogen virulence.
Investigating practice integration of independent prescribing by community pharmacists using normalization process theory: a cross-sectional survey
Authors: Karim L. , McIntosh T. , Jebara T. , Pfleger D. , Osprey A. , Cunningham S.
Published: May 2024

Background

Independent prescribing (IP) has not been extensively investigated in community pharmacy (CP). Normalization process theory (NPT) constructs help explain how interventions are integrated into practice and include: ‘coherence’ (understanding), ‘cognitive participation’ (what promotes engagement), ‘collective action’ (integration with existing systems), and ‘reflexive monitoring’ (evaluation).

Aim

To use NPT to investigate the integration of pharmacist IP in CP.

Method

NHS Scotland Pharmacy First Plus (PFP) is a community pharmacy IP service. Questionnaire items were developed using the NPT derived Normalisation MeAsure Development (NoMAD) tool for an online survey of all PFP IP pharmacists. Demographic data were analysed descriptively and scale scores (calculated from item scores for the 4 NPT constructs) were used for inferential analysis.

Results

There was a 73% (88/120) response rate. Greater than 90% ‘strongly agreed’/‘agreed’ to NoMAD items relating to most NPT constructs. However, responses to ‘collective action’ items were diverse with more participants answering ‘neither agree nor disagree’ or ‘disagree’. A statistically significant difference in NPT construct scale scores with significant p-values (ranging from p < 0.001 to p = 0.033) was shown on all the NPT constructs for the variable ‘On average, how often do you consult with patients under the PFP service?’.

Conclusion

This theory-based work offers perspectives on IP integration within CP. Despite its geographic focus this work offers insights relevant to wider contexts on IP integration. It shows ‘collective action’ focused ‘organisation’ and ‘group process’ challenges with a need for further work on staff training, resource availability and utilisation, working relationships, communication and management.
The tempest within: the origins and outcomes of intense national emotions in times of national division
Authors: Feinstein Yuval
Published: May 2024

Theories of intense national emotions have focused on affection for the home nation and antagonism for national others but overlooked antagonism for fellow nationals. The article introduces a comprehensive theory of intense national emotions. It first discusses the sources of the potential energy stored in national identities, pointing to a combination of two factors: the nation is at once potent due to its capacity to shield against existential threats and precarious due to its dependence on the reproduction of contested narratives. The article then explains that events that—through a construction process elaborated in the text—seem to threaten or promise to alter perceived core elements of the nation (i.e., “nation-disrupting events”) evoke intense emotions. Next, the article explains why some periods of "hot" nationalism increase national division rather than unity. The conclusion proposes a promising direction for future research on intense national emotions as a mechanism of eventfulness.
Recruitment of Volunteers with Immigrant Backgrounds: The Impact of Structural and Individual Aspects
Authors: Sveen Silje , Anthun Kirsti Sarheim , Tingvold Laila
Published: May 2024

Volunteering is associated with health-promoting benefits for both recipients and volunteers and may contribute to a more inclusive society. However, studies have shown a persistent pattern of social inequality among those who volunteer, and immigrants participate as volunteers less than the majority population. To date, approaches for recruiting immigrant populations have not been sufficiently examined, even though multicultural societies are becoming increasingly diverse. This study investigates how recruitment is carried out in voluntary organizations and how volunteers who are involved in recruitment reflect on the inclusion of citizens with immigrant backgrounds. Qualitative interviews were conducted with 18 volunteers and three employees with recruitment responsibility at five voluntary organizations engaged in welfare and community-related activities in a semirural district in Norway. Our findings show that different structural factors and individual aspects of the recruiter influence the recruitment of immigrants as volunteers. Large-scale organizations are more professionalized and more directed by fundings and frameworks and demand more qualifications due to their volunteer tasks. This might make inclusive recruitment more challenging. Small-scale organizations have more flexibility and less professionalized volunteer activities, making recruitment more inclusive. In addition, if the small-scale organizations are minority driven, it seems to positively influence the recruitment of immigrants through increased diversity sensitivity and more connections with immigrants through their social network.
Psychologically Traumatic Birth: Associations with Increased Drinking and Delayed Risk of Alcohol Harm in Mothers
Authors: Jones Andrew , Hunt Sally , Rose Abigail K.
Published: May 2024

Background

Experience of trauma is a risk factor for increased alcohol use. Childbirth can be psychologically traumatic but there is minimal research investigating whether psychological birth trauma (PBT) is a risk factor for increased maternal drinking or what factors are associated with alcohol use in mothers who have and who have not experienced PBT.

Method

An online observational survey of mothers with (n = 291) and without (n = 230) experience of PBT. Participants self-reported alcohol use and completed measures of alcohol harm, drinking motives, trauma (general and birth related) and mental health. Free text options were included to complement quantitative data.

Results

Irrespective of PBT status, stronger endorsement of negative reinforcement drinking motives (e.g. coping) predicted higher alcohol use and hazardous drinking. However, children’s age influenced this relationship. In mothers with a history of PBT, negative reinforcement drinking motives predicted weekly alcohol use and alcohol harm as their children grew older. In mothers without PBT, positive reinforcement drinking motives predicted greater weekly alcohol use as children grew older, but negative drinking motives predicted reduced drinking. Multiple aspects of the parental role influenced drinking (e.g. coping-based motives) and non-drinking (e.g. child well-being motives) behaviour. Changes in motives from pre-motherhood to motherhood focused around a shift from positive to negative reinforcement drinking motives. Mothers with PBT reported mental health symptoms as both a reason to drink and not to drink alcohol.

Conclusion

This study provides novel evidence on maternal alcohol use, and how PBT may influence drinking behaviour in mothers. Importantly, PBT may be a type of trauma which is associated with a delayed risk for maladaptive alcohol use and risk of alcohol harm. This evidence can facilitate more research aimed at understanding this important public health issue and can inform alcohol interventions tailored to the needs of mothers which consider the long-lasting impact of birth experience.
The role of semaphorin 3A on chondrogenic differentiation
Authors: Tsuboi Eri , Asakawa Yuki , Hirose Naoto , Yanoshita Makoto , Sumi Chikako , Takano Mami , Onishi Azusa , Nishiyama Sayuri , Kubo Naoki , Kita Daiki , Tanimoto Kotaro
Published: May 2024

Osteoblast-derived semaphorin3A (Sema3A) has been reported to be involved in bone protection, and Sema3A knockout mice have been reported to exhibit chondrodysplasia. From these reports, Sema3A is considered to be involved in chondrogenic differentiation and skeletal formation, but there are many unclear points about its function and mechanism in chondrogenic differentiation. This study investigated the pharmacological effects of Sema3A in chondrogenic differentiation. The amount of Sema3A secreted into the culture supernatant was measured using an enzyme-linked immunosorbent assay. The expression of chondrogenic differentiation-related factors, such as Type II collagen (COL2A1), Aggrecan (ACAN), hyaluronan synthase 2 (HAS2), SRY-box transcription factor 9 (Sox9), Runt-related transcription factor 2 (Runx2), and Type X collagen (COL10A1) in ATDC5 cells treated with Sema3A (1,10 and 100 ng/mL) was examined using real-time reverse transcription polymerase chain reaction. Further, to assess the deposition of total glycosaminoglycans during chondrogenic differentiation, ATDC5 cells were stained with Alcian Blue. Moreover, the amount of hyaluronan in the culture supernatant was measured by enzyme-linked immunosorbent assay. The addition of Sema3A to cultured ATDC5 cells increased the expression of Sox9, Runx2, COL2A1, ACAN, HAS2, and COL10A1 during chondrogenic differentiation. Moreover, it enhanced total proteoglycan and hyaluronan synthesis. Further, Sema3A was upregulated in the early stages of chondrogenic differentiation, and its secretion decreased later. Sema3A increases extracellular matrix production and promotes chondrogenic differentiation. To the best of our knowledge, this is the first study to demonstrate the role of Sema3A on chondrogenic differentiation.
Pharmacotherapy in Stress Urinary Incontinence; A Literature Review
Authors: Tabei Seyed Sajjad , Baas Wesley , Mahdy Ayman
Published: May 2024

Purpose of Review

Stress urinary incontinence (SUI) is a commonly observed condition in females, as well as in males who have undergone prostatectomy. Despite the significant progress made in surgical techniques, pharmacotherapy has not yielded substantial outcomes within the clinical domain. This review aims to present a comprehensive overview of the existing pharmacotherapy options for stress urinary incontinence (SUI) and the emerging therapeutic targets in this field.

Recent Findings

One meta-analysis demonstrated that α-adrenergic medications are more efficacious in improving rather than curing SUI symptoms. One trial showed reduced pad weight gain with PSD-503, a locally administered α-adrenergic receptor agonist. New data show that duloxetine’s risk outweighs its benefits. One small-scale trial was found to support the use of locally administered estriol in improving subjective outcomes. Emerging targets include serotonin 5HT2C agonists, selective inhibitors of norepinephrine uptake, and myostatin inhibitors.

Only one of the evaluated drugs, duloxetine, has been approved by some countries. Currently, trials are evaluating novel targets. Systemic adverse effects such as gastrointestinal upset with duloxetine and orthostatic hypotension with α-adrenoceptor agonists have hampered the efficacy of drugs used to treat SUI in women and men.
Age-related patterns in mandibular third molar eruption: presenting new forensic age assessment reference data from a Chinese population
Authors: Timme Maximilian , Viktorov Jan , Steffens Laurin , Streeter Adam , Karch André , Guo Yu-Cheng , Schmeling Andreas
Published: May 2024

Valid reference data are essential for reliable forensic age assessment procedures in the living, a fact that extends to the trait of mandibular third molar eruption in dental panoramic radiographs (PAN). The objective of this study was to acquire valid reference data for a northern Chinese population. The study was guided by the criteria for reference studies in age assessment.

To this end, a study population from China comprising 917 panoramic radiographs obtained from 430 females and 487 males aged between 15.00 and 25.99 years was analysed. Of the 917 PANs, a total of 1230 mandibular third molars were evaluated.

The PANs, retrospectively evaluated, were performed for medical indication during the period from 2016 to 2021. The assessment of mandibular third molars was conducted using the staging scale presented by Olze et al. in 2012. Two independent examiners, trained in assessing PANs for forensic age estimation, evaluated the images. In instances where the two examiners diverged in their assessments these were subsequently deliberated, and a consensus stage was assigned.

The mean age increased with higher stages for both teeth and both sexes. The minimum age recorded for stage D, indicating complete tooth eruption, was 15.6 years in females and 16.1 years in males. Consequently, the completion of mandibular third molar eruption was observed in both sexes well before reaching the age of 18. In light of our results, it is evident that relying solely on the assessment of mandibular third molar eruption may not be sufficient for accurately determining the age of majority. Contrary to previous literature, this finding of a completed eruption of the mandibular third molars in northern Chinese individuals is only suitable for detecting the completion of the 16th year of life in males according to our results. However, as the results are inconsistent compared to other studies in the literature, the trait should not be used as the only decisive marker to prove this age threshold in males from northern China.
Prioritising Important Plant Areas (IPAs) among the limestone karsts of Perak, Malaysia
Authors: Tan Joanne P. C. , Kiew Ruth , Darbyshire Iain
Published: May 2024

The flora of limestone karsts is exceptionally rich, due in particular to the wide array of microhabitats that limestone outcrops support. However, in Peninsular Malaysia limestone outcrops are heavily exploited for the quarry industry, cave temples, leisure venues and the development of geoparks, hence the limestone flora is amongst the most threatened biodiversity in the Peninsula. The 95 limestone karsts in Perak are currently known to support 538 species, representing c. 44.2% of the total limestone flora of Peninsular Malaysia. Of these, 13.2% (71 species) are endemic to the Peninsula of which 10 species are hyper-endemic (i.e. restricted to a single karst), 108 (20%) are threatened with extinction and 6 are considered likely to be Extinct. Typical of limestone in Peninsular Malaysia, a single karst harbours only a fraction of the total limestone flora such that a network of karsts is required to capture maximum plant diversity. Through evaluation of data from field surveys, herbarium specimens and the literature, 27 of the Perak karsts were found to trigger Important Plant Area (IPA) status, i.e. they harbour important populations of threatened species, outstanding botanical richness and/or are important examples of threatened habitats that in Perak include the foothills and limestone forest. Fifteen karsts were identified for priority conservation measures based on Conservation Priority Scores (CPS), a quantitative methodology based on endemic and threatened status. With the addition of two species-rich karst sites, 17 karsts are recommended as the first iteration of the network of priority IPA sites for Perak that together conserve 90% (483 species) of the Perak limestone plant diversity, 93% (66) of the endemic species and 94.4% (102) of the threatened species. CPS is found to be more reliable than using total species richness for assessing conservation importance and we also demonstrate that karst size and isolation are not primary indicators of range-restricted plant diversity. Significant knowledge gaps still exist, with 59 karsts in Perak without botanical surveys, and with many rare species having not been recollected for over 30 years, emphasising the need for further botanical research in these important and threatened landscapes.
Marsh-orchids of Canada: long-standing mysteries partially solved
Authors: Bateman Richard M. , Meades Susan J. , Denholm Ian , Tyteca Daniel , Hedrén Mikael
Published: May 2024

Between 1959 and 1988, three populations of purple-flowered terrestrial orchids attributable to Dactylorhiza subgenus Dactylorhiza were discovered in Canada. The populations at Timmins, Ontario, and St John's, Newfoundland were strongly marked on both flowers and leaves, in contrast with the anthocyanin-deficient population at Tilt Cove, Newfoundland. All three populations have since experienced a wide range of taxonomic assignments; debates are also ongoing regarding their origin and most appropriate conservation status. Here, we address these questions by combining detailed in situ morphometric analyses based on 52 characters with allozyme profiles and data from nrITS, 15 plastid microsatellites and seven nuclear microsatellites. The allozyme data alone are sufficient to both confirm allopolyploidy and categorically refute past assignments of these populations to D. incarnata, D. maculata, D. fuchsii, D. majalis or D. purpurella. Several morphometric characters, nuclear microsatellites and nrITS all reliably distinguish each of the three study populations, whereas the two sampled subpopulations from St John's proved near-identical morphologically. In contrast, morphological variation within each of the three populations is strikingly low, particularly in characters other than those influenced by plant vigour. Similarly, compared with 14 European populations, the three Canadian populations proved genetically impoverished (two were near-invariant) and likely experienced recent, extreme genetic bottlenecks during establishment. The three populations differ substantially, both morphologically and molecularly, therefore probably representing independent immigration events. Although clearly attributable to D. praetermissa, all three populations deviate significantly in morphology and DNA data from comparable populations sampled across Europe, preventing identification of their precise geographic origins. Any attempt to determine their mode or origin — through natural long-distance transport, or accidental or deliberate introduction by humans – is challenged to explain why three lineages of a single European Marsh-orchid species, each in different ways atypical of that species, arrived independently in North America whereas no other European dactylorchid species has become established there.
In Defense of Introspective Affordances
Authors: Gray David Miguel
Published: May 2024

Psychological and philosophical studies have extended J. J. Gibson’s notion of affordances. Affordances are possibilities for bodily action presented to us by the objects of our perception. Recent work has argued that we should extend the actions afforded by perception to mental action. I argue that we can extend the notion of affordance itself. What I call ‘Introspective Affordances’ are possibilities for mental action presented to us by introspectively accessible states. While there are some prima facie worries concerning the non-perceptual nature of introspection, I will argue that our internal mental lives share enough commonalities with experiences in our environment to warrant this extension. I will demonstrate the value of introspective affordances by showing how they allow us to explain an underexplored aspect of thought insertion.
Pregnancy in Transmasculine, Non-binary, and Gender Expansive Patients
Authors: Cantwell Christopher J.
Published: May 2024

Purpose of Review

Transgender, non-binary, and gender expansive (TNGE) patients may choose to become pregnant and will require pregnancy-related care. To date, there has been limited research on pregnancy in this community. This review article aims to collate and summarize the most recent literature and make recommendations for providing pregnancy care to TNGE patients.

Recent Findings

TNGE patients can successfully undergo fertility preservation before or after starting their gender transition and may be able to continue gender-affirming hormone therapy with testosterone (GAHT-T) during the process. GAHT-T is potentially teratogenic and should be discontinued in pregnancy; however, GAHT-T does not appear to affect birth outcomes in TNGE patients. Clinicians should be aware that pregnancy can have profound physical and psychosocial impacts on TNGE patients, and patients frequently identify a lack of knowledgeable providers and welcoming care settings as barriers to care. Postpartum TNGE patients may be at increased risk of postpartum mood disorders. They may also choose to chest feed and require extra support and accommodations to be successful in this endeavor.

TNGE patients should be provided the same standard pregnancy-related care as their cisgender counterparts. Special consideration should be given to fertility preservation, contraception, postpartum mood disorders, and lactation/chest feeding as TNGE patients have unique needs within these areas. Much of the available research in this population is retrospective and qualitative with small sample sizes. Future research should focus on larger-scale quantitative studies to help develop evidenced-based, community-informed guidelines for care.
In-vacuum post-compression of optical probe pulses for relativistic plasma diagnostics
Authors: Lorenz S. , Grittani G. M. , Kondo K. , Kon A. , Liu Y.-K. , Sagisaka A. , Ogura K. , Nakanii N. , Huang K. , Bierwage A. , Namba S. , Ohiro H. , Pikuz T. A. , Koga J. K. , Chen P. , Kiriyama H. , Kando M. , Esirkepov T. Zh. , Bulanov S. V. , Pirozhkov A. S.
Published: May 2024

Ultrafast optical probing is a widely used method of underdense plasma diagnostic. In relativistic plasma, the motion blur limits spatial resolution in the direction of motion. For many high-power lasers the initial pulse duration of 30–50 fs results in a 10–15 μm motion blur, which can be reduced by probe pulse post-compression. Here we used the compression after compressor approach [Phys.-Usp. 62, 1096 (2019); JINST 17 P07035 (2022)], where spectral broadening is performed in thin optical plates and is followed by reflections from negative-dispersion mirrors. Our initially low-intensity probe beam was down-collimated for a more efficient spectral broadening and higher probe-to-self-emission intensity ratio. The setup is compact, fits in a vacuum chamber and can be implemented within a short experimental time slot. We proved that the compressed pulse retained the high quality necessary for plasma probing.
Self-diffusiophoretic propulsion of a spheroidal particle in a shear-thinning fluid
Authors: Zhu Guangpu , van Gogh Brandon , Zhu Lailai , Pak On Shun , Man Yi
Published: May 2024

Shear-thinning viscosity is a non-Newtonian behaviour that active particles often encounter in biological fluids such as blood and mucus. The fundamental question of how this ubiquitous non-Newtonian rheology affects the propulsion of active particles has attracted substantial interest. In particular, spherical Janus particles driven by self-diffusiophoresis, a major physico-chemical propulsion mechanism of synthetic active particles, were shown to always swim slower in a shear-thinning fluid than in a Newtonian fluid. In this work, we move beyond the spherical limit to examine the effect of particle eccentricity on self-diffusiophoretic propulsion in a shear-thinning fluid. We use a combination of asymptotic analysis and numerical simulations to show that shear-thinning rheology can enhance self-diffusiophoretic propulsion of a spheroidal particle, in stark contrast to previous findings for the spherical case. A systematic characterization of the dependence of the propulsion speed on the particle's active surface coverage has also uncovered an intriguing feature associated with the propulsion speeds of a pair of complementarily coated particles not previously reported. Symmetry arguments are presented to elucidate how this new feature emerges as a combined effect of anisotropy of the spheroidal geometry and nonlinearity in fluid rheology.
Lacking Legislative Experience: The Impact of Changing Justice Backgrounds on Judicial Review
Authors: Robinson Rob
Published: May 2024

Though once commonplace, presidents no longer nominate individuals with legislative experience to the U.S. Supreme Court. What difference does this shift make? Drawing on theories that connect judicial background characteristics to decision-making, I test whether legislative background impacts federal judicial review. Using nonparametric matching and almost 150 years of judicial review decisions, I find that, while such experience decreases the likelihood of striking down a law, the effect is small. By contrast, partisanship has a much stronger impact, with justices more likely to strike down laws when the enacting Congressional majority is a different party from their appointing president.
A variable stiffness design method for soft robotic fingers based on grasping force compensation and linearization
Authors: Shan Xiaowei , Xu Litao , Li Xuefei
Published: May 2024

Soft fingers play an increasingly important role in robotic grippers to achieve adaptive grasping with variable stiffness features. Previous studies of soft finger design have primarily focused on the optimization of the structural parameters of existing finger structures, but limited efforts have been put into the design methodology from fundamental grasping mechanisms to finger structures with desired grasping force features. To this aim, a fundamental architecture of soft fingers is proposed for analyzing common soft finger features and the influence of the internal structures on the overall grasping performance. In addition, three general performance metrics are introduced to evaluate the grasping performance of soft finger designs. Then, a novel method is proposed to combine the variable stiffness structure with the fundamental architecture to compensate for the grasping force of the finger and linearization. Subsequently, an embodiment design is proposed with a cantilever spring-based variable stiffness (CSVS) mechanism based on the method, and a multi-objective optimization method is employed to optimize the design. Besides, the CSVS features are analyzed through finite element analysis (FEA), and by comparing the grasping performance between the V-shape finger and the CSVS finger, it is demonstrated that the design method can effectively shorten the pre-grasp stage and linearize the grasping force in the post-grasp stage while reducing the likelihood of sliding friction between the finger and the grasped object. Finally, experiments are conducted to validate the accuracy of the FEA model, the effectiveness of the design methodology, and the adaptability of the CSVS finger.
Examining Dutch children’s vocabularies across infancy and toddlerhood: Demographic effects are age-specific and task-specific
Authors: van der Klis Anika , Junge Caroline , Adriaans Frans , Kager René
Published: May 2024

Limited studies have examined demographic differences in children’s vocabulary in longitudinal samples, while there are questions regarding the duration, direction, and magnitude of these effects across development. In this longitudinal study, we included over 400 Dutch children. Caregivers filled out N-CDIs when children were 9–11 months (measuring word comprehension, word production, and gestures) and around 2–5 years of age (measuring word production). At 2–5 years, we also administered a receptive vocabulary task in the lab. We examined demographic effects on vocabulary size across infancy and toddlerhood. We found a disadvantage for males in infants’ gestures and toddlers’ vocabulary production. We found a negative effect of maternal education on infants’ caregiver-reported vocabulary, but a positive effect on toddlers’ lab-administered receptive vocabulary. Lastly, we found a negative effect of multilingualism – but only for the lab-administered task. Examining predictors in large, longitudinal samples ensures their robustness and generalisability across development.
Mosses of Cockburn Island plateau, Antarctica
Authors: Cottet Agustina Celeste , Messuti María Inés , Ansaldo Martín , Dopchiz Laura Patricia
Published: May 2024

Located east of the Antarctic Peninsula, Cockburn Island is a small island in the James Ross Archipelago. Studies of mosses on the island are scarce. The oldest studies date from the first half of the nineteenth century to the most recent in 1993. The number of records of mosses is very small due to the difficulty of accessing the area. Here, we report an updated composition of the moss flora of the plateau, in which four new records have been found: Bryoerythrophyllum antarcticum, Ceratodon purpureus, Pohlia wilsonii and Schistidium lewis-smithii. The occurrence of these species on the plateau shows that the ranges of these species have expanded from the Antarctic Peninsula to the east. This collection highlights the need for further research into the dynamics of moss flora in the context of climate change.