bluuebunny/crossref_metadata_2025 huggingface dataset:
Βιοφυσική και βιοχημική μελέτη του ρόλου της καλμοδουλίνης και των μεταλλαγμάτων της στα μονοπάτια σηματοδότηση Ca2+
Authors: Κοντογιάννη Αγγελική-Ίρις
Published: October 2023

Τα τελευταία χρόνια έρευνες έχουν συσχετίσει πληθώρα μεταλλάξεων και στα τρία γονίδια (CALM1,CALM2,CALM3) που κωδικοποιούν την καλμοδουλίνη (CaM) με παθολογικούς φαινότυπους θνησιγενών κολπικών αρρυθμιών, κυρίως CPVT και LQTS. Η CaM είναι μία πολυλειτουργική πρωτεϊνη δέσμευσης Ca2+ που μεταξύ άλλων αποτελεί σημαντικό ρυθμιστή των υποδοχέων ρυανοδίνης 2 (RyR2) και κατέχει σημαντικό ρόλο στη σηματοδότηση του Ca2+, κατά το μηχανισμό διέγερσης-συστολής των καρδιομυοκυττάρων (ECC). Ο ακριβής μηχανισμός της αλληλεπίδρασης μεταξύ CaM και RyR2 δεν είναι πλήρως γνωστός, γεγονός που προκαλεί δυσκολία στη μελέτη και τον προσδιορισμό του μηχανισμού που μπορεί να οδηγεί σε καλμοδουλινοπάθειες. Η παρούσα διατριβή συμβάλλει στην καλύτερη κατανόηση του μηχανισμού αλληλεπίδρασης μεταξύ CaM-RyR2, μέσω της μελέτης της επίδρασης CaM-μεταλλάξεων, που έχουν συσχετισθεί με θνησιγενή αρρυθμιογενή καρδιακά σύνδρομα, τόσο στο ίδιο το μόριο της CaM όσο και στην αλληλεπίδραση με τον RyR2. Αρχικά, ερευνάται η επίδραση που επιφέρουν ορισμένες CaM μεταλλάξεις στο μόριο της CaM αγρίου τύπου (CaMwt) απο πλευράς δομής, θερμικής σταθερότητας και ικανότητας δέσμευσης Ca2+ με τις τεχνικές της φασματοπολωσιμετρίας κυκλικού διχροϊσμού (CD) και της φασματοσκοπίας φθορισμού. Στη συνέχεια, μελετάται η αλληλεπίδραση της CaMwt και ορισμένων εκ των CaM μεταλλαγμένων μορφών με συνθετικά πεπτίδια που αφορούν στην κύρια περιοχή πρόσδεσης της CaM στον RyR2 (πεπτίδιο Β) και σε μία δεύτερη περιοχή του RyR2, που πιθανώς αποτελεί και αυτή περιοχή πρόσδεσης της CaM (πεπτίδιο F). Η θερμοδυναμική μελέτη της εν λόγω αλληλελεπίδρασης πραγματοποιείται με χρήση της θερμιδομετρίας ισόθερμης τιτλοδοτησης (ITC). Όλες οι μεταλλαγμένες μορφές της CaM που μελετήθηκαν στην παρούσα εργασία διατηρούν την τριτοταγή τους διαμόρφωση, τόσο παρουσία όσο και απουσία Ca2+. Κατά πλειονότητα οι μεταλλάξεις προκαλούν σε διαφορετικό βαθμό απώλεια στη θερμοσταθερότητα του μορίου της CaM, που σχετίζεται με τη δέσμευση Ca2+ και προκαλούν μείωση στη συγγένεια σύνδεσης του Ca2+ στο C-λοβό. Οι δύο αλληλουχίες του ανθρώπινου RyR2 (πεπτίδια Β και F) βρέθηκε να αλληλεπιδρούν με υψηλή συγγένεια με την CaMwt, τόσο παρουσία όσο και απουσία Ca2+, γεγονός που υποδεικνύει πως το πεπτίδιο F αποτελεί πιθανή περιοχή πρόσδεσης της CaM στον RyR2. Τα αποτελέσματα της αλληλεπίδρασης των μεταλλαγμένων CaM με τα πεπτίδια Β και F, έδωσαν σε ένα γενικό πλαίσιο μικρές μεταβολές στη συγγένεια σύνδεσης σε σχέση με την CaMwt που δεν επηρεάζουν την ικανότητα πρόσδεσης της CaM στον υποδοχέα, παρουσία Ca2+. Η απουσία Ca2+ αποκλείει την πρόσδεση των μεταλλαγμένων μορφών της CaM και στα δύο πεπτίδια. Η εργασία αυτή χωρίζεται σε δύο μέρη. Στο πρώτο μέρος αναλύεται διεξοδικά το θεωρητικό υπόβαθρο στο οποίο βασίζεται η εν λόγω εργασία, ενώ στο δεύτερο μέρος παρουσιάζονται αναλυτικά όλες οι πειραματικές μέθοδοι που χρησιμοποιήθηκαν σε αυτή τη μελέτη, τα πειραματικά αποτελέσματα και τέλος τα συμπεράσματα που προκύπτουν.
A novel risk score for venous thromboembolism in lung cancer patients: a retrospective cohort study
Authors: Rouis Houda , Moussa Chirine , mejri Islem , Debbiche Soumaya , Khalfallah Nourchene , Ben Hmida Lenda , Khattab Amel , Moetamri Zied , Megdiche Mohamed Lamine , Kamoun Hela , Maâlej Sonia
Published: October 2023

Background: Venous thromboembolism (VTE) is a common and potentially fatal complication in patients with lung cancer. This study aimed to develop and validate a risk score for early prediction of VTE in these patients.

Methods: Four hundred and one patients with lung cancer from three pulmonology departments hospitalized between January 2011 and December 2021 were retrospectively assessed. The population was divided into two groups: a Development Group (182 patients) and a validation group (199 patients). In the development group, the risk score system was developed, via univariate and multivariate analyses, based on demographic and clinicopathological variables; it was then validated in the validation group.

Results: The incidence of VTE was 26.8% in the development group. It was 25.8%, and 27.6% in the internal and external validation groups, respectively. Hemoglobin level <10g/l, metastasis, histological type poorly or undifferentiated non-small cell carcinoma, and active smoking were the items of the risk score system. This score allowed proper stratification of patients with either high or low risk of VTE in the development group (c statistic =0.703). The patients in the development group were classified into 3 risk groups: low risk (scores 0-1), moderate risk (scores 2-3), and high risk (scores 4-5).  When validated in the validation group, there was a moderate loss of predictive power of the score (c statistic=0.641), but the categorization of the patients by the score remained clinically useful.

Conclusions: This risk score requires prospective validation studies on a nationwide scale in order to use it as a valid tool for the prevention of VTE in lung cancer.
Inclusive Approach in the Physical Education of Students
Authors: Kielevyaynen L.
Published: October 2023

The article provides information about the implementation of inclusive space at Petrozavodsk State University. The tasks, required solutions in accordance with the real problems of inclusive education and ways to solve them are presented. Physical and adaptive physical culture are presented as a means of implementing an inclusive space in the higher education system. The GTO festival and training sessions carried out by students with disabilities are effective practices of social integration and professional self-realization.
Leaders Circle In Facilitating School Heads' Instructional Supervision Practices For Continuing Professional Development
Authors: Potane Joel , Alano Isabel Anne M. , Ongcachuy Braziel L.
Published: October 2023

Instructional supervision is the process of ensuring that a school's educational mission is carried out by supervising, equipping, and empowering teachers to provide students with meaningful learning experiences. The study explored school heads' instructional supervision practices for continuing professional development through Leaders' Circle via a learning management system, which provides school leaders with opportunities to communicate, collaborate, critically think, be creative, and share experiences related to instructional supervision. The process owners of the instructional supervision process encountered a problem that they resolved using the Continuous Improvement (CI) learning cycle. The participants were chosen based on the prioritization matrix. Asynchronous style via Schoology and face-to-face sessions were used. The data collection tools for this study were the leaders circle manual, in-depth interviews (IDIs), and Focus Group discussions (FGDs). Qualitative analysis identified recurring themes. The circle of the leaders promotes the following: (1) professional development; (2) character development; and (3) collaboration with other school administrators.
Dental and oral health education in parents of taam avicenna playgroup students
Authors: Pargaputri Agni Febrina , Maharani Aulia Dwi , Patrika Fauziah Julike
Published: October 2023

Oral and dental health education aims to increase knowledge that leads to better dental and oral health behaviors. Parents play an important role in children's behavior to maintain dental and oral health. Lack of behavior to maintain healthy teeth can be caused by low knowledge of dental and oral health. This activity aim to provide dental and oral health education to parents of students in Taam Avicenna Surabaya playgroup. This activity was carried out by providing dental health education media such as flipcharts, posters, and dental phantoms. Then post-test was given to the participants. Questionnaires regarding the behavior of maintaining dental and oral health were also given. The results showed that the understanding of parents with good categories was more than those with moderate and low categories. This means that some parents can receive dental health education well. Providing dental health education has a positive impact on understanding and knowledge of dental and oral health in parents. It can be concluded that by giving dental health education for parents of students in Taam Avicenna Surabaya playgroup, could enhance understanding and knowledge of dental and oral health so that it could help parents to improve behavior in oral and dental health.
Diários (1909-1923), de Franz Kafka, em tradução de Sergio Telarolli
Authors: Lugão Juliana Serôa da Motta
Published: October 2023

Resenha do livro:
KAFKA, Franz. Diários – 1909-1923. Trad. Sergio Tellaroli. São Paulo: Todavia, 2021.
Addressing the gender gap in urinary continence care
Authors: Yates Ann
Published: October 2023

Urinary incontinence is a common condition that affects both men and women, and with profoundly negative effects. Prevalence figures do show that it is more common in younger women than men, but as people age the difference decreases, with research identifying that one-in-three older men have continence issues. However, even with this increase, there is little direct best practice guidance on addressing male urinary incontinence compared to that for women. Professionals seem to be unaware that men have known existing barriers to accessing health care and this would be especially true for incontinence care. There seems to be a lack of education in identifying and assessing symptoms, and little thought to appropriate management if required. This can also be true of manufacturers that provide continence management equipment. This article will look at some of these themes and highlight the gender gaps and give guidance on how professionals may address these.
The recovery period
Authors: Scales Courtney
Published: October 2023

Recovery from anaesthesia begins when the maintenance agent is discontinued and the patient starts to regain consciousness. The importance of patient monitoring throughout the recovery period should not be underestimated and no matter the patient or procedure, individual risks for the recovery period should be identified and mitigated. Each patient will recover differently from their anaesthetic experience. How the pre-anaesthesia, induction and maintenance phases of the anaesthesia have been prepared and planned will contribute to how the patient will recover.
Care of the acute kidney injury patient
Authors: Maund Victoria
Published: October 2023

Acute kidney injury, previously called acute renal failure, indicates a sudden and often reversible reduction in kidney function as measured by glomerular filtration rate, increased serum and plasma creatinine concentration and changes in urine output. This article reviews the pathophysiology and common causes of acute kidney injuries, including pre-renal causes from hypovolaemia, intrinsic renal causes such as glomerular diseases and post-renal obstructive causes. Veterinary nurses should be aware of the common diagnostic tests used and how to deliver support to the hospitalised patient. While an acute kidney injury can be a serious condition for some patients, it is possible for others to recover and maintain a good quality of life with effective nursing care to help maximise the prognosis of these patients.
“Trust the Women”: Dora Meeson Coates’s Suffrage Banner and the Popular Construction of Australia’s Feminist Past in the Late Twentieth Century
Authors: Keating James
Published: October 2023

En 1988, le gouvernement fédéral australien a acheté la bannière « Trust the Women » de l’artiste anglo-australienne Dora Meeson Coates dans le cadre des efforts tardifs du pays pour commémorer les victoires en matière de suffrage qui avaient jadis permis à ses citoyens Blancs d’être le peuple avec le droit de vote le plus étendu de la planète. Cependant, entre la fin du siècle et les années 1970, une période qui a vu la montée simultanée de l’histoire des femmes et du féminisme d’État, les féministes ont fait preuve d’ambivalence quant à la commémoration des campagnes de suffrage, plus particulièrement au niveau national. Depuis la fin des années 1980, la bannière a connu une transformation, passant d’un artefact dont
peu d’Australiens connaissaient l’existence, et encore moins qu’ils avaient oublié, au symbole le plus familier des mouvements de suffrage du pays. Provoqué par les agents de la mémoire — activistes, bureaucrates, historiens et politiciens—ce changement révèle l’attrait public de l’iconographie du suffrage britannique au détriment de l’enregistrement matériel du labeur « tranquille » des activistes australiens, un sentiment qui a de plus en plus façonné la commémoration des histoires locales du suffrage.
Memory from Below: Emma Goldman, Counter-Monuments, and the Politics of Public Memory
Authors: Shpolberg Angela
Published: October 2023

Deux lieux de commémoration publics dédiés à Emma Goldman (1869-1940), une féministe radicale et pionnière, sont examinés dans le cadre d’une discussion plus large sur la préservation de la mémoire collective féministe. Goldman était une anarchiste de renom qui défendait les droits des femmes, les droits des travailleurs et la liberté d’expression. Tout au long de sa vie, elle s’est entretenue avec le mouvement américain pour le droit de vote des femmes — et a été l’une des rares voix critiques à pousser le mouvement vers des positions toujours plus progressistes émanant de la gauche. La mise en contraste des formes traditionnelles de commémoration et des « contre-monuments » conçus par des artistes et érigés spontanément par ses admirateurs nous permet d’explorer les effets de ces lieux commémoratifs sur les formes que peut prendre la mémoire publique et sur les
enjeux liés à ces choix formels.
Evidence-based comparative severity assessment in young and adult mice
Authors: Reiber Maria , von Schumann Lara , Buchecker Verena , Boldt Lena , Gass Peter , Bleich Andre , Talbot Steven Roger , Potschka Heidrun
Published: October 2023

In animal-based research, welfare assessments are essential for ethical and legal reasons. However, accurate assessment of suffering in laboratory animals is often complicated by the multidimensional character of distress and pain and the associated affective states. The present study aimed to design and validate multidimensional composite measure schemes comprising behavioral and biochemical parameters based on a bioinformatics approach. Published data sets from induced and genetic mouse models of neurological and psychiatric disorders were subjected to a bioinformatics workflow for cross-model analyses. ROC analyses pointed to a model-specific discriminatory power of selected behavioral parameters. Principal component analyses confirmed that the composite measure schemes developed for adult or young mice provided relevant information with the level of group separation reflecting the expected severity levels. Finally, the validity of the composite measure schemes developed for adult and young mice was further confirmed by k-means-based clustering as a basis for severity classification. The classification systems allowed the allocation of individual animals to different severity levels and a direct comparison of animal groups and other models. In conclusion, the bioinformatics approach confirmed the suitability of the composite measure schemes for evidence-based comparative severity assessment in adult and young mice. In particular, we demonstrated that the composite measure schemes provide a basis for an individualized severity classification in control and experimental groups allowing direct comparison of severity levels across different induced or genetic models. An online tool (R package) is provided, allowing the application of the bioinformatics approach to severity assessment data sets regardless of the parameters or models used. This tool can also be used to validate refinement measures.
Living with bronchial asthma: A qualitative study among patients in a hill village in Nepal
Authors: Paudel Sabita , Shankar Pathiyil Ravi , Subedi Nuwadatta , Palaian Subish
Published: October 2023

Introduction

Bronchial asthma continues to be a problem in the Himalayan country of Nepal. This study explored the impact of bronchial asthma on patients’ lives in a hill village in Syangja district, Nepal, and obtained information about the perceived impact of the illness, knowledge of the disease, self-care behaviors and treatment among patients.

Material and methods

The study site is the village of Jyamire (located at an elevation between 900 to 1200 m) Syangja district. Individuals suffering from asthma residing in the village aged 18 years or above were included. Semi-structured interviews were conducted face-to-face with the respondents at their homes using an interview guide. The interviews were audio recorded, transcribed in the Nepali language, and then translated into English for further analysis.

Results

Most participants were female, between 18 to 60 years of age, and housewives. Most houses were built of mud and poorly ventilated. Gas was used for cooking though firewood was also used. Most used to get an average of three serious attacks a year both during winter and summer. The themes that emerged were the number and seasonal variation in attacks, the perceived effect of asthma on their lives and social interactions, the knowledge of the interviewee about the disease, the impact of asthma on their socioeconomic status, and treatment and self-care behaviors. Residing in a hill village required them to walk up and down several times a day and the disease seriously impacted their lives. The smoke produced during different ceremonies and during cooking also worsened their asthma.

Conclusion

Findings suggest, the existence of multiple factors, a few unique to Nepal contributing to poor asthma control. Though the recent socioeconomic improvement has led to improved prevention and treatment options, asthma seriously affected the patients.
Korean fermented soybean paste (Doenjang) has anti-obesity and anti-hypertensive effects via the renin-angiotensin system (RAS) in high-fat diet-induced obese rats
Authors: Woo Hayoung , Han Anna , Park Jung Eun , Cha Youn-Soo
Published: October 2023

The health-beneficial outcomes of doenjang, a Korean fermented food have been questioned due to its high salt content; moreover, the detailed underlying mechanisms of its health beneficial effects are not fully investigated. Thus, this study aimed to investigate doenjang’s anti-obesity effects, anti-hypertensive effects, and its underlying mechanisms in high-fat diet -induced obesity. Sprague-Dawley rats fed with normal diet (ND), high-fat diet (HD), HD with 8% additive salt (HDS), or HD with doenjang containing 8% salt (HDJ) for 13 weeks. Compared to HD and HDS groups, the HDJ group had lower body and epididymal fat tissue weight gain and showed hypotrophy and hypoplasia. The RAS-related mRNA levels in the adipose tissue, including Renin and Ace were downregulated in the HDJ group compared to HD and HDS groups. Additionally, HDJ groups had significant improvements in systolic blood pressure, serum RAS-associated parameters (e.g., angiotensin II and aldosterone), renal mRNA levels related to RAS (e.g., angiotensin II receptor type 1 and 2), and aldosterone-associated mRNA expressions (e.g., mineralocorticoid receptor) in the kidney of HD-induced obese rats. Most importantly, HDS and HDJ groups showed distinct outcomes regarding adipogenesis and electrolytes metabolism, even though both diets contain a high level of salt. HDS group showed a higher epididymal fat tissue weight, mass, and adipocyte size than HDJ group. In addition, compared with HDJ group, HDS group significantly decreased the release of Na+ and K+ throughout the urine and feces. The present study addresses that doenjang has anti-obesity effects and anti-hypertensive effects by activating RAS in the adipose tissue and kidney, respectively. Additionally, this study also demonstrates that salt in doenjang and the additive salt differently influences adipogenesis and electrolytes metabolism, supporting doenjang has health advantageous effects regardless of its high salt contents.
Urbanization and flood risk analysis using geospatial techniques
Authors: Atanga Raphael Ane , Tankpa Vitus , Acquah Isaiah
Published: October 2023

This research investigates the relationship between urbanization as a land use/land cover change and the increased flood disasters in Accra. Understanding this relationship will provide evidence for urban development planners, policy makers and flood managers to coordinate in responding to the problems effectively. This study maps and analyzes the changes in urbanization from 1991 to 2015. The research reviews the trends of flood events in Greater Accra and analyzes the relationship between the pattern of urbanization and the increase in flood disaster events from 1991 to 2015. The research revealed that there was an increase in urban land use/land cover change of up to 95.51% and 129.14% in the periods 1991–2002 and 2002–2015 respectively. The pattern of urbanization took place in an unplanned style, where physical developments in waterways became high. The findings show that the pattern of flood disasters increased from 1991 to 2015 with evidence showing two years having repeated flood events.
Key performance indicators of COVID-19 contact tracing in Belgium from September 2020 to December 2021
Authors: Kremer Cécile , Willem Lander , Boone Jorden , Arrazola de Oñate Wouter , Hammami Naïma , Faes Christel , Hens Niel
Published: October 2023

The goal of tracing, testing, and quarantining contacts of infected individuals is to contain the spread of infectious diseases, a strategy widely used during the COVID-19 pandemic. However, limited research exists on the effectiveness of contact tracing, especially with regard to key performance indicators (KPIs), such as the proportion of cases arising from previously identified contacts. In our study, we analyzed contact tracing data from Belgium collected between September 2020 and December 2021 to assess the impact of contact tracing on SARS-CoV-2 transmission and understand its characteristics. Among confirmed cases involved in contact tracing in the Flemish and Brussels-Capital regions, 19.1% were previously identified as close contacts and were aware of prior exposure. These cases, referred to as ‘known’ to contact tracing operators, reported on average fewer close contacts compared to newly identified individuals (0.80 versus 1.05), resulting in fewer secondary cases (0.23 versus 0.28). Additionally, we calculated the secondary attack rate, representing infections per contact, which was on average lower for the ‘known’ cases (0.22 versus 0.25) between December 2020 and August 2021. These findings indicate the effectiveness of contact tracing in Belgium in reducing SARS-CoV-2 transmission. Although we were unable to quantify the exact number of prevented cases, our findings emphasize the importance of contact tracing as a public health measure. In addition, contact tracing data provide indications of potential shifts in transmission patterns among different age groups associated with emerging variants of concern and increasing vaccination rates.
CONcreTEXT norms: Concreteness ratings for Italian and English words in context
Authors: Montefinese Maria , Gregori Lorenzo , Ravelli Andrea Amelio , Varvara Rossella , Radicioni Daniele Paolo
Published: October 2023

Concreteness is a fundamental dimension of word semantic representation that has attracted more and more interest to become one of the most studied variables in the psycholinguistic and cognitive neuroscience literature in the last decade. Concreteness effects have been found at both the brain and the behavioral levels, but they may vary depending on the constraints of the context and task demands. In this study, we collected concreteness norms for English and Italian words presented in different context sentences to allow better control and manipulation of concreteness in future psycholinguistic research. First, we observed high split-half correlations and Cronbach’s alpha coefficients, suggesting that our ratings were highly reliable and can be used in Italian- and English-speaking populations. Second, our data indicate that the concreteness ratings are related to the lexical density and accessibility of the sentence in both English and Italian. We also found that the concreteness of words in isolation was highly correlated with that of words in context. Finally, we analyzed differences between nouns and verbs in concreteness ratings without significant effects. Our new concreteness norms of words in context are a valuable source of information for future research in both the English and Italian language. The complete database is available on the Open Science Framework (doi:10.17605/OSF.IO/U3PC4).
Association of eye strain with dry eye and retinal thickness
Authors: Ayaki Masahiko , Kuze Manami , Negishi Kazuno
Published: October 2023

Purpose

The purpose of this cohort study was to investigate the association between the prevalence of abnormal ocular examination results and the common visual symptoms of eye strain, blurred vision and photophobia.

Methods

Consecutive first-visit outpatients with best-corrected visual acuity better than 20/30 in both eyes were enrolled and those with a history of intra-ocular lens implantation and glaucoma were excluded. Dry eye-related examinations and retinal thickness measurement were conducted. The odds ratio (OR) was calculated with logistic regression analyses of ocular data in relation to the presence of visual symptoms.

Results

A total of 6078 patients (3920 women, mean age 49.0 ± 20.4 years) were analyzed. The prevalence of each symptom was 31.8% for eye strain, 22.5% for blurred vision and 16.0% for photophobia. A significant risk factor for eye strain was short tear break-up time (TBUT) (OR 1.88), superficial punctate keratitis (SPK) (OR 1.44), and thickness of ganglion cell complex (GCC) (OR 1.30). Risk factors for blurred vision were short TBUT (OR 1.85), SPK (OR 1.24) and GCC (OR 0.59). Risk factors for photophobia were short TBUT (OR 1.77) and SPK (OR 1.32). Schirmer test value, peripapillary nerve fiber layer thickness and full macular thickness were not associated with the tested symptoms.

Conclusion

The current study successfully identified female gender, short TBUT, and SPK as significant risk factors for eye strain, blurred vision, and photophobia with considerable ORs.
A cross-sectional examination of post-myocardial infarction physical activity levels among US rural and urban residents: Findings from the 2017–2019 Behavioral Risk Factor Surveillance System
Authors: Tran Phoebe , Barroso Cristina , Tran Liem
Published: October 2023

Background

This study sought to examine the relationship between rural residence and physical activity levels among US myocardial infarction (MI) survivors.

Methods

We conducted a cross-sectional study using nationally representative Behavioral Risk Factor Surveillance System surveys from 2017 and 2019. We determined the survey-weighted percentage of rural and urban MI survivors meeting US physical activity guidelines. Logistic regression models were used to examine the relationship between rural/urban residence and meeting physical activity guidelines, accounting for sociodemographic factors.

Results

Our study included 22,732 MI survivors (37.3% rural residents). The percentage of rural MI survivors meeting physical activity guidelines (37.4%, 95% CI: 35.1%-39.7%) was significantly less than their urban counterparts (45.6%, 95% CI: 44.0%-47.2%). Rural residence was associated with a 28.8% (95% CI: 20.0%-36.7%) lower odds of meeting physical activity guidelines, with this changing to a 19.3% (95% CI: 9.3%-28.3%) lower odds after adjustment for sociodemographic factors.

Conclusions

A significant rural/urban disparity in physical activity levels exists among US MI survivors. Our findings support the need for further efforts to improve physical activity levels among rural MI survivors as part of successful secondary prevention in US high-MI burden rural areas.
CONTROLE PREVENTIVO DE CONSTITUCIONALIDADE DE EMENDAS CONSTITUCIONAIS: ANÁLISE COMPARADA ENTRE BRASIL E COLÔMBIA
Authors: Dos Santos Beatriz Tavares Fernandes , Lima Jairo Néia
Published: October 2023

Contextualização: Diante da crescente intercomunicação da pesquisa jurídica brasileira com a produção acadêmica internacional, tem surgido, em decorrência disso, um considerável interesse na realização de pesquisas em direito comparado. Contemporaneamente, esse tipo de pesquisa tem colocado novas questões metodológicas que até então não estavam postas para o comparativismo jurídico tradicional, principalmente em razão do amplo acesso às fontes de pesquisa estrangeiras.
Objetivo: Por esse motivo, esse artigo tem como objetivo inicial apresentar os novos desafios da comparação e, a partir disso, demonstrar como se deu a assunção de competência do controle preventivo de constitucionalidade de emendas constitucionais no Brasil e na Colômbia.
Metodologia: Para alcançar esse intento, foi realizado o levantamento de bibliografia específica do tema, de dados documentais e jurisprudenciais para que fossem analisados à luz das mais recentes abordagens metodológicas da comparação jurídica.
Resultados: Concluiu-se que, apesar de suas diferentes disposições constitucionais sobre o tema, ambos os países se destacam pelo protagonismo de suas supremas cortes na condução do reconhecimento da competência para realizar o controle preventivo de emendas constitucionais e que as chaves metodológicas da comparação jurídica apresentadas na pesquisa colaboraram para essa identificação.
Design of composite steel and fibre-concrete columns at elevated temperature
Authors:   , Tkalenko Illia
Published: October 2023

This research is dedicated to the preparation of an analytical model of the mechanical behaviour of circular hollow section columns with steel fibre-reinforced concrete infill in a fire situation based on experimental study and numerical modelling. The work includes data from experimental studies, validation of the numerical model, sensitivity study by numerical simulation and development of an analytical model based on a European standard for the design of reinforced concrete elements in fire EN1994-1-2: 202x. Experimental studies include six full scale column specimens in compression during the heating in steady-state regime. Validation of the three-dimensional numerical finite element method model using ATENA software made based on experimental data. A parametric study aimed to compare fire resistance of centrally and eccentrically loaded circular hollow section columns with steel fibre-reinforced and plain concrete infill in the fire situation. Developed analytical model for determining the design buckling load in the ﬁre situation of the composite steel and fibre-reinforced concrete columns is ready for an Annex or a Supplementary technical document in the corresponding method in prEN1994-1-2:202x.
Brittle fracture of laminated glass structural elements
Authors:   , Schmidt Jaroslav
Published: October 2023

Many damage models have been developed over the past decades, but most of them still struggle to simulate damage without additional ad-hoc criteria or the need for difficult implementation. In particular, brittle fracture models that represent a mathematical singularity are not easy to be simulate correctly. Recently discovered phase field models prove to be advantageous in many ways. These are variationally consistent models that show a high degree of robustness. Problems such as tensile cracking, cracking of a specialized structure in 3D, crack branching or crack initiation are all described by the same set of equations. Since the model uses a regularized damage field, its implementation is also efficient. Laminated glass is a material that needs to be investigated even after cracks appear. Undamaged laminated glass is a stunning material itself, but its undisputed advantage is its cohesiveness and load-bearing capacity even in post-breakage domain. And phase-field models are suitable for simulating this residual load capacity, which allow investigating both the initiation of cracks and their branching and the impact on the structural response. This work is supposed to bring the combination of such phenomena - the simulation of laminated glass before and after the appearance of cracks. Models of different degrees of spatial reduction and structures under different loading are investigated. The work first investigates the quasi-static response of the beams, then stochastically investigates the response when the strength changes and is concluded by investigating the low-velocity impact. The paper primarly tries to create fully applicable approaches for engineering practice and reveals the benefits and shortcomings of such an approach for glass modeling.
Das Landschaftliche in wissenschaftlicher und künstlerischer Praxis
Authors: Krüger Jens Oliver , Westphal Kristin , Kranixfeld Micha , Waburg Wiebke , Sterzenbach Barbara
Published: October 2023

Jens Oliver Krüger, Wiebke Waburg, Kristin Westphal, Micha Kranixfeld und Barbara Sterzenbach beschäftigen sich in ihrem Beitrag mit dem Begriff der Landschaft und dessen ideengeschichtlicher Entwicklung im Kontext von kultureller Bildung und künstlerischen Praxen. Im ersten Teil machen die Autor*innen deutlich, dass Kunst und Pädagogik nicht nur an der Popularisierung eines landschaftlichen Blicks beteiligt waren und sind, sondern dass sie diesem Blick auch unterschiedliche Richtungen weisen. Und egal wohin sich dieser Blick richtet - er ist nie neutral. Im zweiten Teil des Beitrags folgt eine Einführung in die vier Kapitel des Sammelbands und ihre einzelnen Beiträge.
Landschaft und Bildung
Authors: Bilstein Johannes
Published: October 2023

Johannes Bilstein widmet sich in diesem Beitrag der Frage, wie sich das kindliche Weltverhältnis im Bezug auf Landschaft verstehen, beschreiben und kategorisieren lässt. Dabei stellt er die Rolle der Künste in den Vordergrund.
Reflexionen des stereoskopischen Spielfilms
Authors: Feiersinger Luisa
Published: October 2023

Der stereoskopische Unterhaltungsfilm, der sogenannte 3D-Film, ist integraler Bestandteil der Filmgeschichte. Luisa Feiersinger verfolgt in einer longue durée die sich wandelnden narrativen, technischen und diskursiven Anordnungen am Beispiel ausgewählter Unterhaltungsfilme. Dabei zeigt sie, dass gerade im populären Format diese Anordnungen immer wieder selbstreflexiv in die Narrationen verwoben werden. Filmwissenschaftliche Untersuchungsmethoden zur Beschreibung der nur in der Wahrnehmung existierenden stereoskopischen Bewegt- und Raumbilder dienen als exemplarischer Vorschlag zur Integration von Bewegtbildern in die Kunst- und Bildgeschichte.
Ästhetische Eigenlogiken des europäischen Genrebildes: Temporalität, Ambiguität, Latenz
Authors: Brabant Dominik , Hochkirchen Britta
Published: October 2023

In diesem Beitrag widmen sich Dominik Brabant und Britta Hochkirchen der Frage, welche spezifischen Eigenlogiken der Gattung des Genrebildes zugrunde liegen. Die Einleitung bietet, ausgehend von einer Analyse von Gerard ter Borchs Gemälde ,Galante Konversation', einen Überblick zur Debatte über das Genrebild innerhalb der Forschung sowie zur spannungsvollen Positionierung dieser Gattung innerhalb des Gattungsgefüges. Darauf aufbauend wird argumentiert, die Diskussion um die Gattung im Rückgriff auf jüngere bildtheoretische Konzepte neu zu perspektivieren. Hierfür werden die Konzepte der Ambiguität, Temporalität und Latenz eingeführt, ihre Positionierungen innerhalb des Forschungsfeldes erläutert und für die Diskussion um das Genrebild fruchtbar gemacht.
Augenblick und Fragment in Adolph Menzels Genremalerei
Authors: Kohle Hubertus
Published: October 2023

Ausgehend von einigen seiner Historienbilder, die man wohl auch in theoretischer Hinsicht besser Geschichtsbilder nennen sollte, wird versucht, Charakteristika des Menzelschen Genrebildes zu erfassen. Dabei spielen Begriffe wie Verzeitlichung, Fragmentarisierung und Augenblicklichkeit eine Rolle, mit denen der spezifisch moderne Aspekt des wichtigsten deutschen Realisten im 19. Jahrhundert benannt werden soll. Unterwandert wird damit eine Idee von »fruchtbarem Moment«, mit der traditionell eine Erweiterung des im Bild notwendig Momenthaften in eine sinnfällige Narration garantiert werden sollte. Weiter ausgreifend steht eine Parallelisierung mit Friedrich Theodor Vischers Reisebild Auch einer im Vordergrund, dessen skurriler Held geradezu Rollenmodell von Menzels Protagonisten in seinem Marktplatz in Verona von 1884 sein könnte. Eher als Ausblick zu verstehen ist die antiteleologische Grundierung von Menzels Malkunst, die in flagrantem Gegensatz zu allen gängigen idealistischen Modellen der Kunstgeschichte steht.
Implementing Circular Economy in Universities. Successful Practices at Politecnico di Torino (Italy)
Authors: Lombardi Patrizia , Genta Chiara , Colaleo Valentina
Published: October 2023

The circular economy (CE) concept reported a growing interest as an operationalizing framework, able to support the implementation of sustainable production and consumption, resource use and waste prevention broader concepts. Even if CE is different from waste management, it has traditionally been associated with waste reduction, recycling improvement, and minimization of environmental impacts in cities and territories. Additionally, CE could be a driver for the achievement of multiple Sustainable Development Goals (SDGs). On the other side, universities are recognized as key actors in the transition towards sustainable development at the territorial level. Given the use of CE as a possible change paradigm to decouple economic growth from associated environmental impacts, this paper aims at highlighting some of the main successful practices put forwards by an Italian university, Politecnico di Torino, in implementing CE principles.Keyword: Circular Economy, University Sustainability, waste management
From CSR to Impact; How to Integrate CSR in a University Strategy
Authors: Maters Erna , Luttik Joke
Published: October 2023

Wageningen University & Research (WUR) has a Corporate Social Responsibility (CSR) agenda, which was drawn up in 2020, after the adoption of the Strategic Plan. The topic “Research and education to contribute to societal challenges” is at the top of the CSR agenda, because we assume that WUR will have the greatest societal impact through its education and research activities. CSR is all about Impact and impact is a key term in the current strategy. Because CSR, Impact and Strategy are so closely related, especially in a university, it is important to develop new perspectives on how CSR can best be integrated into the strategy. This fits in well with WUR as an organization with a great social responsibility: at an organization like WUR you would expect CSR to be anchored in the core of the organization, so that no separate CSR strategy is needed. The article explores the various ways to embed the CSR perspective in the new Strategic Plan of the organization, describes the strengths and weaknesses of the various approaches and concludes which approach would be the most suitable for a future-proof sustainable university.
Effect of salinity on DNA methylation and antioxidant phenolic compounds of wild watercress (Rorippa nasturtium aquaticum)
Authors: Gutiérrez-Velázquez Marcela Verónica , Almaraz-Abarca Norma , Ávila-Reyes José Antonio , Delgado-Alvarado Eli Amanda , González-Valdez Laura Silvia , Torres-Ricario Rene , Monreal-García Hugo Manuel , Rojas-Barboza Dante Yamid , Vasavilbazo-Saucedo Andrés
Published: October 2023

Epigenetic changes are involved in plant responses to stress. Cytosine methylation is one of the most important epigenetic changes, regulating gene expression. In this paper, the MSAP (methylation-sensitive amplification polymorphism) method was used to find out how the watercress (Rorippa nasturtium aquaticum) genome changed in response to 0, 60, 80, and 100 mM NaCl and how that affected phenylalanine ammonium lyase (PAL) activity, phenolic content, and antioxidant capacity. The results showed an inverse correlation between methylation levels and PAL activity and the contents of total phenolics and flavonoids, indicating salt stress-induced reprogramming of the methylation pattern of watercress, which has a negative effect on the synthesis of phenolics. The results revealed a significant decrease in phenolic contents and antioxidant activity under low and moderate salinity compared to control and an increase under strong salinity compared to moderate salinity. The findings of this study contribute to our understanding of the reprogramming of DNA methylation under salinity and its effect on watercress phenolic metabolism.
Myocardial ischemia – reperfusion injury
Authors: Salo S. V. , Shumakov V. O. , Shpak S. S. , Tokhtarov V. V.
Published: October 2023

Aim. To summarize and broaden the idea about mechanisms of acute coronary insufficiency development and pathophysiological features of myocardial reperfusion injury.
Today, in the event of acute coronary syndrome, according to the latest recommendations for myocardial revascularization, percutaneous coronary intervention should be performed to determine the anatomy of coronary artery lesions and further percutaneous therapy. But in some patients, after blood flow restoration, reperfusion injury occurs, which is primarily related to the duration of ischemia, infarct size, and the myocardial resistance to ischemia.
Treatment of myocardial infarction, like any treatment method, has evolved. In the 60s of the previous century, it included morphine, oxygen, warfarin and bed rest for 4–6 weeks. Then, during the 70s, it consisted of morphine, oxygen, lidocaine, warfarin, bed rest for 2–3 weeks and possibly coronary angiography for the further bypass surgery. The late 1970s saw the rapid progress in thrombolysis, first intravenous and then intracoronary. And starting in the early 1980s, since G. Hartzler performed the first balloon angioplasty for acute coronary artery occlusion, the stage of mechanical myocardial reperfusion has come. At the same time, knowledge about the pathophysiology of acute coronary ischemia was deepened. The World Health Organization developed ECG criteria for acute myocardial infarction using population-based studies in the 1950s–1970s, and additional four normative European regulations since then were issued defining concepts, key points of diagnosis and possible complications of myocardial infarction.
Conclusions. The development of myocardial ischemic-reperfusion injury is a staged process that has a complex pathogenesis, its own clinical manifestations, and an association with more negative long-term outcomes of myocardial infarction treatment. Its main components are myocardial swelling involving cardiomyocytes, endotheliocytes, and the interstitial space; downregulation of cytoskeleton and disruption of sarcolemma integrity; increased vascular wall permeability; spasm of arterioles; intravascular accumulation of platelets and leukocytes, and the resultant the most severe form of myocardial damage is intramyocardial hemorrhage. Clinically, this is manifested by the no-reflow phenomenon following percutaneous coronary intervention.
Rozmowa z Jerzym Hoffmanem
Authors: Krupnyk Liubov
Published: October 2023

An interview with the Polish film director Jerzy Hoffman was recorded on 11–12 July 2022 at his estate in the village of Sikory Yuskie in the Warmian-Masurian Voivodeship. Jerzy Hoffman is perhaps the most popular Polish film director in Ukraine. His films gained recognition even before Ukraine gained independence. However, his most notable work is Ogniem i mieczem [With Fire and Sword, 1999], which starred the great Ukrainian actor Bohdan Stupka (1941–2012) as Hetman Bohdan Chmielnicki. The collaboration continued in the film The Old Tale. When the Sun Was a God (2003). In 2008 Jerzy Hoffman made a four-part documentary film Ukraine. The Birth of a Nation.

The conversation touched on issues related to these films, completed and unrealized projects on Ukraine, reflections on the history of Polish-Ukrainian relations and the role of Jerzy Hoffmann’s work in establishing them. As a filmmaker who closely follows events in Ukraine, he shared his impressions and predictions about how the ongoing war will change and transform Ukraine and the world.
Rozmowa z Krzysztofem Zanussim
Authors: Krupnyk Liubov
Published: October 2023

An interview with the Polish film director Krzysztof Zanussi was conducted on 12 July 2022 at his home on the outskirts of Warsaw. The filmmaker has collaborated with Ukrainian artists, traveled extensively in Ukraine, supported Ukrainians during the war and even sheltered Ukrainian refugees in his home. The conversation focused on his collaborations with Ukrainian artists, in particular the prominent Ukrainian actor Bohdan Stupka (1941–2012). He played the lead role in Krzysztof Zanussi’s film And a Warm Heart (2008), for which he received the Best Actor award at the Third Rome International Film Festival for the first time in the history of Ukrainian cinema. The conversation also touched on the director’s personal ties with Ukraine, his views on the problems of the development of Ukrainian culture, his memories of creative contacts, including those during the Soviet period, and his experience of working with Russian artists. The filmmaker shared his thoughts on the war in Ukraine and its possible consequences, including those for the development of art.
Methods for designing strategic narratives in the description of the 2022 Russian-Ukrainian war in documentaries
Authors: Rosinska Olena , Tymińska Marta
Published: October 2023

The article discusses methods of designing strategic narratives in teledocumentaries created by various production teams and distributed through the YouTube platform. The authors underline the important role of teledocumentaries in creating an emotional and intellectual response to geopolitical topics among television viewers and attempt to analyse six documentaries focusing on the current war in Ukraine. The aim of the research was to determine key narrative patterns that are presented by production teams from various countries in the context of the armed aggression of the Russian forces in Ukraine. From this research, we can outline three main narrative templates: identity issues (“Us” vs. “Them”), temporal cognition and feeling of “stopping the time”, the image of enemy inter-twined with death, unforgiveness and fear.
Turkish EFL Learners’ Motivational Self Systems: A Cross-sectional Study
Authors: COURSE Simla , SAKA Fatma Özlem
Published: October 2023

This paper reports the findings of a research, with a twofold aim of investigating L2 motivational self system of Turkish EFL learners and exploring how the constructs of this model interact with each other. To this end, we conducted a mixed methods research with 1168 participants from three populations of Turkish EFL learners, secondary school, high school and university students. The findings show that the tripartite mode of L2 motivational self system explains the Turkish EFL learners’ language learning motivation and that the constructs of this model contribute towards the language learning motivation following different paths for the three groups of learners from secondary school, high school and university. To investigate the possible changes these constructs undergo over time, language learning motivation trajectories of individual learners were also explored. The findings show that there is a dynamic interplay among these constructs. The findings also indicate patterns and emergence of attractor states in these interactions. Finally, it is found that the attractor states themselves also undergo changes over the learners’ trajectories, shaping whilst being shaped by the components of L2 motivational self system.