bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the Railway Effect of the Coordinated Development of the Economy and Environment in the Chengdu–Chongqing Economic Circle
Authors: Shen Jia , Ren Xiaohong , Feng Zhitao
Published: April 2024

Transportation infrastructure plays a crucial role in economic development and significantly influences climate change, providing direct and indirect benefits towards the attainment of Goals 8 and 13 of the United Nations Sustainable Development Goals (SDGs). This study investigates the impact of railway infrastructure on the level of economic and environmental coordination development in the Chengdu–Chongqing economic circle, using panel data from 16 cities spanning from 2010 to 2020. The analysis employs a coupled coordination degree model and a panel fixed effects model. The findings reveal a gradual increase in the level of economic and environmental coordination development in each city during the study period. Notably, Chongqing and Chengdu exhibit significantly higher levels compared to other cities. Railway infrastructure construction can significantly promote the coordinated development of the urban economy and environment. In areas with a high level of coordinated development of the economy and environment, the promoting effect is relatively small, while in areas with a low level of coordinated development of the economy and environment, the promoting effect is relatively large. Over the long term, railways continue to significantly promote the coordinated development of the urban economy and environment. The construction of railways can stimulate the development of the urban private economy and marketization, thereby facilitating the coordinated development of the urban economy and environment.
Measurement and Influencing Factors of Regional Economic Resilience in China
Authors: Zhang Xinyu , Tian Congying
Published: April 2024

The COVID-19 outbreak in 2020 has underscored the paramount importance of regional economies’ capacities to withstand and adapt to external shocks. Enhancing regional economic resilience and mitigating the adverse impacts on both the economy and society have emerged as critical imperatives for ensuring the sustainable development and transformation of the national economy. This paper employs an improved counterfactual method to measure the economic resilience index across 31 Chinese provinces and cities from 2001 to 2021, coupled with empirical analysis using a dynamic panel model to identify the influencing factors of regional economic resilience. Building upon this foundation, the study delves into the heterogeneous effects of various factors and different degrees of marketization on economic resilience across different regions. Research Findings: (1) There has been a significant improvement in the economic resilience levels of China’s 31 provinces, with differences in economic resilience between regions far exceeding those in economic development levels, indicating substantial internal regional disparities. (2) Factors such as the marketization index, industrial structure, level of informatization, labor force size, labor quality, innovation capacity, and degree of government intervention all impact regional economic resilience and exhibit regional heterogeneity. Policy Recommendations: (1) It is crucial to address regional disparities while formulating regional development strategies and enhancing regional economic resilience. (2) Regions should accelerate market-oriented reforms, promote rational labor mobility, strengthen investment in human capital, foster innovation, and adjust the degree of intervention.
Toxicity of Cry- and Vip3Aa-Class Proteins and Their Interactions against Spodoptera frugiperda (Lepidoptera: Noctuidae)
Authors: Liu Xiaobei , Liu Shen , Bai Shuxiong , He Kanglai , Zhang Yongjun , Dong Hui , Zhang Tiantao , Wang Zhenying
Published: April 2024

The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), is one of the most important insect pests affecting corn crops worldwide. Although planting transgenic corn expressing Bacillus thuringiensis (Bt) toxins has been approved as being effective against FAW, its populations’ resistance to Bt crops has emerged in different locations around the world. Therefore, it is important to understand the interaction between different Bt proteins, thereby delaying the development of resistance. In this study, we performed diet-overlay bioassays to evaluate the toxicity of Cry1Ab, Cry1Ac, Cry1B, Cry1Ca, Cry1F, Cry2Aa, Cry2Ab, Vip3Aa11, Vip3Aa19, and Vip3Aa20, as well as the interaction between Cry1Ab-, Cry1F-, Cry2Ab-, and Vip3Aa-class proteins against FAW. According to our results, the LC50 values of Bt proteins varied from 12.62 ng/cm2 to >9000 ng/cm2 (protein/diet), among which the Vip3Aa class had the best insecticidal effect. The combination of Cry1Ab and Vip3Aa11 exhibited additive effects at a 5:1 ratio. Cry1F and Vip3Aa11 combinations exhibited additive effects at 1:1, 1:2, and 5:1 ratios. The combination of Cry1F and Vip3Aa19 showed an antagonistic effect when the ratio was 1:1 and an additive effect when the ratio was 1:2, 2:1, 1:5, and 5:1. Additionally, the combinations of Cry1F and Vip3Aa20 showed antagonistic effects at 1:2 and 5:1 ratios and additive effects at 1:1 and 2:1 ratios. In addition to the above combinations, which had additive or antagonistic effects, other combinations exhibited synergistic effects, with variations in synergistic factors (SFs). These results can be applied to the establishment of new pyramided transgenic crops with suitable candidates, providing a basis for FAW control and resistance management strategies.
Sigma-Class Glutathione Transferases (GSTσ): A New Target with Potential for Helminth Control
Authors: Sánchez Pérez Lluvia de Carolina , Zubillaga Rafael A. , García-Gutiérrez Ponciano , Landa Abraham
Published: April 2024

Glutathione transferases (GSTs EC 2.5.1.18) are critical components of phase II metabolism, instrumental in xenobiotics’ metabolism. Their primary function involves conjugating glutathione to both endogenous and exogenous toxic compounds, which increases their solubility and enables their ejection from cells. They also play a role in the transport of non-substrate compounds and immunomodulation, aiding in parasite establishment within its host. The cytosolic GST subfamily is the most abundant and diverse in helminths, and sigma-class GST (GSTσ) belongs to it. This review focuses on three key functions of GSTσ: serving as a detoxifying agent that provides drug resistance, functioning as an immune system modulator through its involvement in prostaglandins synthesis, and acting as a vaccine antigen.
Sustainable Urban Design Model for Residential Neighborhoods Utilizing Sustainability Assessment-Based Approach
Authors: Enab Diana , Zawawi Zahraa , Monna Sameh
Published: April 2024

The sustainable urban design of residential neighborhoods plays an important role in the efforts to achieve the sustainable development goals and alleviate the effects of climate change. This paper aims to develop a model for the sustainable urban design of residential neighborhoods, taking into account the local condition in Palestinian territories. This model is built on various international neighborhood sustainability assessment (NSA) tools, based on the review of existing assessment tools, to study the sustainability status of Palestinian neighborhoods, and to develop a sustainable indicator model for local sustainable neighborhood assessment. Computer tools like Urbano and GIS tools as well as qualitative assessment methods are used. Results from the case study showed that the satisfaction of the preferred location indicator was not sufficient to maintain its sustainability. The assessment of measured indicators found that weaknesses were almost double the count of the satisfactory indicator. Moreover, some indicators from the (NSA) tools were partially or completely met, and some gaps appeared because of the lack of strengths in the selected indicators of the international tools when used for local social, ecological and governmental aspects, and there are issues in the inclusion of economic and environmental elements in current urban configurations. The proposed local model offers valuable insights for local governments, municipalities, and construction developers.
Co-Transcriptional Regulation of HBV Replication: RNA Quality Also Matters
Authors: Giraud Guillaume , El Achi Khadija , Zoulim Fabien , Testoni Barbara
Published: April 2024

Chronic hepatitis B (CHB) virus infection is a major public health burden and the leading cause of hepatocellular carcinoma. Despite the efficacy of current treatments, hepatitis B virus (HBV) cannot be fully eradicated due to the persistence of its minichromosome, or covalently closed circular DNA (cccDNA). The HBV community is investing large human and financial resources to develop new therapeutic strategies that either silence or ideally degrade cccDNA, to cure HBV completely or functionally. cccDNA transcription is considered to be the key step for HBV replication. Transcription not only influences the levels of viral RNA produced, but also directly impacts their quality, generating multiple variants. Growing evidence advocates for the role of the co-transcriptional regulation of HBV RNAs during CHB and viral replication, paving the way for the development of novel therapies targeting these processes. This review focuses on the mechanisms controlling the different co-transcriptional processes that HBV RNAs undergo, and their contribution to both viral replication and HBV-induced liver pathogenesis.
Correction: Dehkordi et al. An Empirical Relation for Estimating Sediment Particle Size in Meandering Gravel-Bed Rivers. Water 2024, 16, 444
Authors: Dehkordi Arman Nejat , Sharafati Ahmad , Mehraein Mojtaba , Hosseini Seyed Abbas
Published: April 2024

There were errors in the original publication [...]
The impact of conventional cigarettes, e-cigarettes, and tobacco heating systems on the oral mucosa
Authors: Miklyaev S. V. , Blokhina N. A. , Chuprikov N. S.
Published: April 2024

Relevance. Over the past few years, the popularity of nicotine-containing substances and tobacco heating systems has continued to grow, while the demand for conventional tobacco leaf cigarettes has been falling. Electronic cigarettes consist of a heating system and a liquid with various flavorings. During the operation of the heating stick, the liquid is converted into an aerosol, which the user needs to inhale. First of all, the hot steam comes into contact with the oral cavity. The aerosol components settle on the oral mucosa, the approximal surfaces of the teeth, penetrating the body with a saliva current, expose the oral cavity to prolonged exposure, causing various changes in the oral cavity and causing discomfort to the smoker. This problem is urgent and based on the above, it is necessary to study all possible effects of cigarettes and electronic nicotine delivery systems on the human body.

Purpose. To assess the impact of nicotine-containing products and smokeless tobacco on the oral mucosa.

Materials and methods. A cohort of 98 patients, aged 20 to 60, was recruited for the study. Participants were divided into four groups: Group 1 consisted of conventional cigarette smokers; Group 2, users of vapes; Group 3, users of IQOS; and Group 4 included patients who used all three device types interchangeably.

Results. The investigation identified a direct correlation between the participant's age, the device used, and their level of oral hygiene. The poorest oral hygiene was seen in Group 4, where individuals used a combination of conventional cigarettes, vapes, and IQOS. Although a majority acknowledged the harmful effects of tobacco products, only 33 participants were aware of the negative impacts associated with vapes and IQOS.

Conclusion. The lack of regulation and awareness of the health risks associated with IQOS and vaping pose substantial challenges for healthcare, indicating a need for more research into these issues.
Adaptation of the composite finite element framework for semilinear parabolic problems
Authors: Anand Anjaly , Pramanick Tamal
Published: April 2024

In this article, we discuss one type of finite element method (FEM), known as the composite finite element method (CFE). Dimensionality reduction is the primary benefit of CFE as it helps to reduce the complexity of the domain space. The number of degrees of freedom is greater in standard FEM compared to CFE. We consider the semilinear parabolic problem in a 2D convex polygonal domain. The analysis of the semidiscrete method for the problem is carried out initially in the CFE framework. Here, the discretization is carried out only in space. Then, the fully discrete problem is taken into account, where both the spatial and time components get discretized. In the fully discrete case, the backward Euler method and the Crank-Nicolson method in the CFE framework are adapted for the semilinear problem. The properties of convergence are derived and the error estimates are examined. It is verified that the order of convergence is preserved. The results obtained from the numerical computations are also provided.
Flexible Two-Dimensional Inorganic Nanosheet/PEDOT:PSS Thermoelectric Composite Films
Authors: Qin Jie , Du Yong , Wang Lei , Du Minzhi , Eklund Per , Ke Qinfei
Published: April 2024

Flexible thermoelectric generators (f-TEGs) are of importance for self-powered, portable, and wearable electronics. The materials’ thermoelectric (TE) performance is one of the factors that affect the conversion efficiency of f-TEGs. Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) as a kind of conducting polymers has low thermal conductivity and good processability in solution; however, its TE properties are still much lower than those of the inorganic TE materials, which limits its wide applications in f-TEGs. Two-dimensional (2D) inorganic nanosheets (NSs) exfoliated from their corresponding powders are promising filler materials for enhancing the TE properties of PEDOT:PSS. This paper provides a brief review on the research progress of flexible 2D inorganic NS/PEDOT:PSS composite films fabricated by vacuum filtration, drop casting, and spin coating. The challenges, perspectives, and outlooks of flexible 2D inorganic NS/PEDOT:PSS composite films are further discussed.
Melatonin Mitigates Atrazine-Induced Renal Tubular Epithelial Cell Senescence by Promoting Parkin-Mediated Mitophagy
Authors: Shi Yu-Sheng , Yang Tian-Ning , Wang Yu-Xiang , Ma Xiang-Yu , Liu Shuo , Zhao Yi , Li Jin-Long
Published: April 2024

The accumulation of senescent cells in kidneys is considered to contribute to age-related diseases and organismal aging. Mitochondria are considered a regulator of cell senescence process. Atrazine as a triazine herbicide poses a threat to renal health by disrupting mitochondrial homeostasis. Melatonin plays a critical role in maintaining mitochondrial homeostasis. The present study aims to explore the mechanism by which melatonin alleviates atrazine-induced renal injury and whether parkin-mediated mitophagy contributes to mitigating cell senescence. The study found that the level of parkin was decreased after atrazine exposure and negatively correlated with senescent markers. Melatonin treatment increased serum melatonin levels and mitigates atrazine-induced renal tubular epithelial cell senescence. Mechanistically, melatonin maintains the integrity of mitochondrial crista structure by increasing the levels of mitochondrial contact site and cristae organizing system, mitochondrial transcription factor A (TFAM), adenosine triphosphatase family AAA domain-containing protein 3A (ATAD3A), and sorting and assembly machinery 50 (Sam50) to prevent mitochondrial DNA release and subsequent activation of cyclic guanosine 5′-monophosphate–adenosine 5′-monophosphate synthase pathway. Furthermore, melatonin activates Sirtuin 3–superoxide dismutase 2 axis to eliminate the accumulation of reactive oxygen species in the kidney. More importantly, the antisenescence role of melatonin is largely determined by the activation of parkin-dependent mitophagy. These results offer novel insights into measures against cell senescence. Parkin-mediated mitophagy is a promising drug target for alleviating renal tubular epithelial cell senescence.
USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D
Authors: Wang Liqiu , Li Mengqiu , Lian Guangyu , Yang Shuai , Wu Yaoxing , Cui Jun
Published: April 2024

As a key executioner of pyroptosis, Gasdermin D (GSDMD) plays a crucial role in host defense and emerges as an essential therapeutic target in the treatment of inflammatory diseases. So far, the understanding of the mechanisms that regulate the protein level of GSDMD to prevent detrimental effects and maintain homeostasis is currently limited. Here, we unveil that ubiquitin-specific peptidase 18 (USP18) works as a negative regulator of pyroptosis by targeting GSDMD for degradation and preventing excessive innate immune responses. Mechanically, USP18 recruits E3 ubiquitin ligase mind bomb homolog 2 (MIB2) to catalyze ubiquitination on GSDMD at lysine (K) 168, which acts as a recognition signal for the selective autophagic degradation of GSDMD. We further confirm the alleviating effect of USP18 on LPS-triggered inflammation in vivo. Collectively, our study demonstrates the role of USP18 in regulating GSDMD-mediated pyroptosis and reveals a previously unknown mechanism by which GSDMD protein level is rigorously controlled by selective autophagy.
The evolution of burn care research since the Bali bombing in 2002
Authors: Wood Fiona M
Published: April 2024

Fiona Wood AM looks back over the 20 years since the Bali bombing to understand how burn care has progressed and changed.
Evaluation of the effect of using sewage sludge as a fertilizer on the concentration of heavy metals in soil and the economic implications of its application
Authors: Petryk Agnieszka , Ryczek Marek , Guzdek Sylwia
Published: April 2024

The costs of fertilising the soil with sewage sludge were reduced to the operating time of the equipment and the working time of the labourers operating the equipment in the two main operations (manure spreading and ploughing), for three sewage sludge application doses, namely 50, 100 and 200 Mg·ha-1. The costs were calculated using the Katalog Nakładów Rzeczowych nr 2-21: Tereny zielone/Ministerstwo Gospodarki Przestrzennej i Budownictwa (2009) and the current prices from Sekocendbud (2023). The effectiveness of fertilisation was assessed by studying the level and change in heavy metal content after the soil was fertilised with sewage sludge at three proportional doses, namely 50, 100 and 200 Mg·kg-1. The sewage sludge used for fertilisation complied with the sanitary requirements for sludge to be utilised for natural purposes (Regulation, 2015). The estimated total cost of sludge application ranged from PLN 12646.19 to PLN 20456.73 per 1 ha for doses from 50 to 200 Mg per 1 ha. The results of the estimation confirmed the hypothesis that the unit cost of fertilisation with stabilised sewage sludge increases with the dose of sludge in relation to the area of fertilised soil and decreases with the increase of the mass of sludge deposited in the soil. Optimising fertiliser costs, therefore, requires selection - increasing the sludge dose per unit area. No contamination of the soil with copper, cadmium, lead and zinc was found despite an obvious increase in the content of these metals when mixed into the soil. The application of sewage sludge, even in multiple doses, did not result in exceeding the permissible limit for the content of these elements in the soil, as defined in the Minister of the Environment Regulation of 2015 (Regulation, 2015).
JOINT OPTIMIZATION OF COLD-CHAIN PICK-UP VEHICLE ROUTING AND CARGO ALLOCATION FOR FRESH AGRICULTURAL PRODUCTS
Authors: WU Jingqiong , WU Xuke , HUANG Jiabo
Published: April 2024

As a bridge connecting agricultural production and consumption, the circulation of agricultural products has the function of connecting supply and demand, guiding production and promoting consumption. However, the development of rural logistics in China is slow, and most logistics centers still rely on experience to plan the pick-up vehicle routings, resulting in long transport time and high cost. In order to improve the efficiency of pick-up and reduce transportation costs, a joint optimization model of cold-chain pick-up vehicle routing and cargo allocation for fresh agricultural products was proposed in this study. Soft time window constraint and three-dimensional loading constraints were considered, and the lowest pick-up cost was used as optimization goals in this model. In addition, adaptive large neighborhood search algorithm (ALNS) and heuristic depth-first search algorithm (HDFS) were combined to solve the model. A case study of Kunming International Flower Auction Center was conducted to compare the schemes of pick-up vehicle routing before and after optimization. Results demonstrate that the pick-up cost after optimization decreases by 9.6 %, the number of vehicles decreases by one, the total volume utilization rate of vehicles increases by 23 %, and the total load utilization rate of vehicles increases by 15 %. This study provides a model reference and solution method for enterprise operators to formulate schemes of pick-up vehicle routing quickly and reasonably.
Pharmacoeconomic aspects of drug provision for diabetic patients in the Novosibirsk Region
Authors: Kharina Inna A. , Dzhuparova Irina A.
Published: April 2024

Aim – to assess pharmacological and economic aspects of drug provision for patients with diabetes mellitus in the Novosibirsk region at federal and regional levels for the period of 2019–2021.
Material and methods. An array of data on drug provision for diabetic patients in the Novosibirsk region for the period of 2019–2021 was collected and subjected to analysis. The research process used a systematic approach with the following methods: logical analysis, content analysis, ABC analysis, XYZ analysis.
Results. For the period of 2019–2021, the burden on the regional drug provision system for diabetic patients had been steadily increasing. At the same time, the share of costs for drug provision for diabetic patients at the federal level continued to grow, despite the reducing number of covered prescriptions. Potentially, it could be explained by the constant increase in the average cost of a prescription. The ABC/XYZ inventory analysis of the consumed drugs and medical devices showed an increasing need for additional (non-hypoglycemic) medicines for the treatment of complications and concomitant diseases in diabetic patients. A greater increase in prescriptions of additional medicines and their funding was observed at the regional level in the period of 2019–2021.
InGaN-based blue, green monolithic micro-LED display with n-type interlayer
Authors: Okuno Koji , Goshonoo Koichi , Ohya Masaki
Published: April 2024

InGaN-based monolithic full-color LEDs, such as augmented reality and virtual reality, are candidates for displays with highly integrated pixels. We demonstrated a monolithic micro-LED display with green- and blue-emitting active layers separated by an n-type interlayer. The interlayer plays an important role in individually emitting green and blue light. The monolithic LED display was fabricated by mesa formation reaching the interlayer and the regrowth of the p-type layer, resulting in horizontally integrated green and blue LEDs. The display measuring 0.64 mm2 with 20 rows and 20 columns had 40 μm × 40 μm pixels comprising 20 μm × 40 μm sub-pixels with an emitting area of 8 μm × 23 μm and was driven by a passive matrix circuit. Images of the monolithic micro-LED display were successfully obtained by individually controlling the green- and blue-emitting micro-LEDs. These results will enhance the commercialization of micro-LED displays.
Irrational behavioral models of personal finance and their evolution in the digital economy
Authors: Tserkasevich L. V.
Published: April 2024

Aim. To review the evolution of scientific concepts investigating the motives for decision[1]making based on irrational consumer behavior and to identify real changes in behavioral models   of personal finance.   Objectives. To examine the evolution of scientific concepts of the world’s leading scientists on   decision-making motives in the consumer market; to consider the effects of irrational consumer   behavior; to identify key changes in consumer buying decision behavior caused by digitalization.

 Methods. The article is based on the analysis of scientific works of leading classical economists,   interdisciplinary scientific research of modern foreign and domestic scientists devoted to the   issues of decision-making in the field of consumption. The institutional approach was applied,   which allowed us to study the evolution of irrational behavior in the field of personal finance   depending on the dominant social values.

 Results. In the process of analyzing theoretical provisions of famous scientists up to the middle   of the twentieth century, the justification of consumers’ decision-making in the consumer market   based on their desire to maximize pleasure, utility of welfare is presented. Such behavior can be   attributed to irrational behavior. Gradually, taking into account the market regulators of consumption opportunities, scientists come to the conclusion about the rational behavior of individuals. However, by the end of the twentieth century, the position of scientists changes towards   limited rationality due to the inability of individuals to adequately assess the array of information   affecting decision-making in the consumer market. On the basis of conclusions drawn by modern   scientists in the framework of interdisciplinary research, such a new direction of economic science   as “behavioral economics” emerges, which combined the knowledge of both economics and psychology. Modern research has shown some effects in behavioral finance related to the irrationality of   consumer behavior when making a purchase decision: the Veblen effect, the Diderot effect and   others. The latest research on the impact of digitalization on consumer behavior reflects the   changes taking place in consumer behavior towards rationalization.

  Conclusions. The concepts and models describing the peculiarities of irrational behavior of   individuals related to decision-making and based on irrational spending of personal financial   resources from the point of view of classical economic science are considered. The evolution of   scientific concepts of irrational behavior of the world’s leading economists during two centuries   is presented. The effects of irrational consumer behavior proposed by scientists in the framework   of interdisciplinary research are studied. Among them are the Veblen effect, the Diderot effect.   The influence of digitalization on personal finance decision-making is shown.
Modern mechanisms of state management of sustainable development
Authors: Fuyuan Xi
Published: April 2024

Aim. To analyze contemporary mechanisms of public governance of sustainable development (SD) with a focus on the energy transition and climate agenda.

Objectives. To focus on strategies and practices adopted in China and Russia, comparing their approaches to achieving SD goals; to examine international experience, analyze investments in renewable energy sources (RES) and decarbonization; to review adopted regulations and management strategies in these areas; to study national and international strategies, legislation and practices aimed at increasing the share of RES and reducing carbon dioxide emissions; to assess the effectiveness of measures taken to manage SD (with special attention to the e

Methods. This article is based on the analysis of data from reports of international organizations, statistical data of governmental bodies, as well as on the review of national strategies and legislation. Mechanisms and results of RES management, climate policy and decarbonization in different countries are compared.

Results. Despite differences in approaches and strategic priorities, both Russia and China are making significant efforts to accelerate the transition to sustainable energy systems and reduce greenhouse gas emissions. However, China demonstrates a more active and ambitious RE policy and climate initiatives, while Russia is at an early stage of this process.

Conclusions. The importance of global and regional cooperation in sharing experiences and technologies to achieve SD goals is emphasized. Both Russia and China demonstrate a growing understanding of the need to regulate SD, but their approaches and strategies differ depending on internal and external factors.
Bureaucratic structure of management of the organization in today’s conditions of uncertainty
Authors: Elkina O. S. , Pavlov A. E.
Published: April 2024

Aim. To prove the facts of inefficiency of application of bureaucratic type of organizational structure of management, lack of its influence on economic growth in the conditions of growing global economic uncertainty.

 Objectives. To systematize the negative features of the bureaucratic model of management, reflected in the works of researchers of the XX century (among them - E. Downs, M. Crozier, B. Guy Peters, D. Flemming, V. Wriston, L. O’Tol), in particular, the lack of flexibility to external uncertain conditions, slow reengineering of business processes under the current realities of economic reality, the lack of motivation to develop the innovative potential of the subject; to study the impact of strong bureaucratic management on economic growth in the works of scientists of the late XX century. (P. Evans, D. Rauch); to reveal the contradiction in the XX century studies and prove that the bureaucratic organizational structure of management has a fading, sometimes stagnating influence on economic growth in the conditions of increasing economic uncertainty.

Results. The paper investigated and found that the theory of the influence of the bureaucratic model on economic growth is confirmed on the example of 1960-2000. However, since the 2000s, which is proved in the research process, the bureaucratic organizational structure of management has a waning, sometimes stagnant effect on economic growth under conditions of increasing economic uncertainty. Consequently, bureaucratization of processes and bureaucratic organization is unable to respond to uncertainty. This is because the transition to the new century is marked by the introduction of the antipatterns of bureaucracy: digital technologies, artificial intelligence economy, flexible methods focused on situational management.

Conclusions. The results revealed in this study prove the necessity of choosing a different type of organizational structure, not based on the bureaucratic model, in the conditions of permanent crisis and increasing uncertainty in the economy
Development of the circulation of digital financial assets in the world in the context of digital transformation
Authors: Ivleva E. S. , Makarov M. Yu. , Bobrov A. G.
Published: April 2024

Aim. To study and describe the main trends in the development of the world market of digital financial assets in the conditions of digital transformation.

 Objectives. To disclose the essence and role of digital transformation at the present stage; to consider the emergence of digital financial assets and the possibilities of their application against the background of high growth rates of the cryptoasset market; to analyze the main indicators of digital currencies as of February 2024; to identify the key characteristics of the use of cryptocurrencies by different countries; to rank countries according to the index of cryptocurrency ownership for 2023; to describe the development trends of the circulation of digital financial assets in the world in the conditions of digital transformation.

Methods. The study uses complex and logical approaches, general scientific methods (analysis, synthesis), methods of comparative and economic analysis, analytical processing and graphical presentation of information.

Results. The leading trends in the development of the global market of digital financial assets in the conditions of digital transformation have been considered. The indicators of the top 10 largest digital currencies by market capitalization are highlighted. Based on the results of the study, the ranking of countries by the index of cryptocurrency ownership for 2023 was compiled. The main indicators of digital currencies for February 2024 were analyzed. The key characteristics of cryptocurrency use by different countries in the context of high rate of digital transformation were described.

Conclusions. The results of the conducted research allowed us to conclude that the current transformation of the global economy, associated with the active development of breakthrough technologies, including distributed ledger technologies (DLT) and blockchain, has become a trigger for the emergence of digital financial assets and expanded the possibilities of their application in the context of high growth rate of the cryptoasset market. The analysis of the current state and development of the circulation of digital financial assets in the world under the conditions of digital transformation shows the growing interest in the use of cryptocurrencies and the introduction of blockchain technologies in the financial systems of various countries, as well as the growing use of cryptocurrencies by companies and individuals. Taking into account the review of global trends, development of fintech technologies, the conclusion is made about the inevitability of the processes of digitalization of financial assets, the emergence of new forms of digital assets, which dictate the need for advanced development of their legal regulation. In the future, the development of digital assets will give them the official status of a means of payment and expand their use in the system of financial relations in the conditions of digital transformation both in Russia and abroad.
Effects of Moringa oleifera, Allium sativum, Zingiber officinale on the haematological parameters and histopathological changes in visceral organs of Clarias gariepinus infected with Pseudomonas aeruginosa
Authors: Oghenochuko O.M. , Mshelbwala F. M.
Published: April 2024

Bacterial resistance to synthetic antibiotics is been a worrisome issue globally resulting in the search for alternative medicament for the treatment of bacterial infection in man, fish and other livestock. The study investigated the histological changes caused by selected medicinal plant extracts on sub-adults of the sharp tooth African catfish Clarias gariepinus experimentally infected with Pseudomonas aeruginosa. Phytochemical screening of test plants was done using standard methods. Agar well diffusion method was used to screen susceptibility of P. aeruginosa; ATCC 27853 to extracts of Moringa oleifera, Allium sativum, Zingiber officinale and oxytetracycline at 1000 mg/ml, 750 mg/ml and 500 mg/ml. Three fish samples from each group were tested for immune response and histopathological alterations. Saponins, terpenoids, flavonoids, cardiac glycoside, anthraquinone and alkaloids were present in test plants. Values of packed cell volume was 29.33%, 30.67%, 34.33%, 25.33% and 22.33% in fish exposed to oxytetracycline, Z. officinale, M. oleifera, A. sativum and untreated fish respectively. Similar trend was observed in the levels of red blood cell, haemoglobin and lymphocyte. White blood cell and neutrophil values were comparatively high in the untreated than treated fish. Organs of untreated fish showed degenerations in gill lamellae, gastric glands and hepatocytes while treated fish organs showed slight regeneration. The studied medicinal plant extracts showed significant antibacterial activity and compared with oxytetracycline in the treatment of P. aeruginosa diseases in fish. Use of these medicinal plants enhanced cultured fish immune responses.
Analysis of productivity of apiculture among ADP contact farmers in Ohafia agricultural zone of Abia State, Nigeria
Authors: Ebe F. E. , Obike K. C , Oti O. G. , Agha U. J.
Published: April 2024

This study was conducted in Ohafia Agricultural Zone of Abia State. The study assessed the productivity of ADP contact apiculturists and the constraints militating against the productivity of the apiculturists. The study used purposive and random sampling techniques to select 60 beekeepers. Data were collected from the apiculturists through primary source. The collected data were analysed using total factor productivity, multiple regression analysis and Likerty scale. The result of the findings showed that mean productivity of the apiculturists was 4.25kg/N. The result further indicated that education, experience and number of bee hive positively and significantly influenced the productivity of the respondents while age was negatively signed and significant. The major constraints on the productivity were climate change, bush burning, deforestation, poor government intervention, poor extension contact etc. Policy should aim at full implementation of laws guiding bush burning and deforestation. The farmers should be advised to always clear the bushes around their beekeeping surroundings at the onset of dry seasons in order to ward off the bush being burned by fire. Also the few extension agents in the field should be encouraged to visit and teach the apiculturists the improved technologies on beekeeping so as to increase the knowledge of the beekeepers and enhance the productivity of the apiculturists.
Household characteristics and agricultural extension services - as correlates of socio-economic status among farming households in Edo State, Nigeria
Authors: Akioya A.O. , Onemolease E.A.
Published: April 2024

This study assessed household’s characteristics and agricultural extension services as correlates of socio-economic status among farming households in Edo state, Nigeria. The enquiry relied on data sourced from 394 respondents, randomly selected from the three agricultural zones in the state. Frequency, mean, multiple regression and asset formation index were deployed in addressing the objectives of the study. Results showed majority of the households were headed by male (70.99%), most respondents had formal education (85%), were married (57%) and were members of cooperative societies (73.28%). About 37% of the respondents had high socio-economic status (i.e., non-poor), 49.87% were moderately poor while 13.49% had low socio-economic status. Many (80.92%) respondents had contact with extension personnel in the past year, with the modal contact frequency (56.49%) being 1-3 times. Major technologies adopted by respondents included herbicides (67.97%), improved crop varieties (65.14%) and fertilizer (62.9%). Regression result showed that membership of cooperative society (b = 0.061), sex (b = 0.080), farming experience (b = -0.013), family size (b = -0.008), loan access (b = 0.072) and volume of loan (b = -0.023), and technology adoption (b = 0.064) were significant factors affecting farmers’ socio-economic status. The study concludes that the agricultural extension services (ADP) contributed positively and significantly to socio-economic status among farming households in the study area. It recommended that the extension service establish further contacts with farmers to encourage higher adoption of improved farm practices.
Proximate and mineral composition of Pelusios castaneus (West African mud turtle) flesh sold in Edo State, Nigeria
Authors: Odiko A. E. , Chidi D. , Agbo D. O.
Published: April 2024

This study was undertaken to determine the proximate and mineral composition of Pelusios castaneus (West African-mud turtle) so as to contribute to the availability of data in Nigeria. A total of thirteen (13) male and female each of African mud turtle (Pelusios casteneus) were purchased in Benin City, Nigeria. Specimen were identified to species level, stunned and slaughtered; then each of the turtle were dissected into flanges and Microwave digestion system (Closed Vessels Acid Digestion – MARS System - CEM) procedure was used for the digestion of all the samples based on organic extraction technique before the proximate composition and the mineral contents of the flesh were determined using AOAC methods and standard technique. Data were analyzed using SPSS (version 21) and statistically using ANOVA and DMRT. Result shows that there were significant variations in the different parameters studied; the highest and lowest moisture content values of 67.00% and 52.56% were observed in the male and female respectively. Highest crude protein and lipid values of 26.78% and 15.00%, were observed in the female respectively; while the highest ash content value of 11.33% was observed in the male. While the mean mineral concentrations in the flesh varied among the different elements studied, the overall potassium had the highest value of 4030.82mg while the least value was observed in magnesium (871.04mg). Though Pelusios castaneus has been culturally important to Nigerians, the finding shows that the flesh is a valuable source of mineral elements and proximate components required in diet. Domestication in Nigeria is therefore encouraged to make them commercially available to reduce the pressure on their harvest from the wild thus preventing their going into extinction.
Comparative analyses of growth parameters of pure Clarias gariepinus and its hybrid in monosex culture
Authors: Kareem-Ibrahim K. O. , Hedonukun M.S. , Adebambo S.M. , Abanikannda O.T.F.
Published: April 2024

This study compared sexual differences in growth parameters of pure and hybrid African catfishes (Clarias gariepinus and Clariabranchus) raised in a monosex culture. The two species were obtained from 281 fishes comprising 150 pure breed and 131 hybrids in an earlier study and grouped by sex separately as male and female in four separate plastic tanks, representing two replicates per sex. Ten each of the pure clarias and its hybrid were reared in each tank. In all, 40 male and 40 female fish comprising 20 each of the pure clarias and its hybrid for each sex were evaluated for the growth parameters. A total of 80 fish were included in this study and the study lasted nine (9) weeks. The fish were fed commercially compounded feed twice daily throughout the period of the experiment. Length-weight relationship and growth parameters such as Mean Growth Rate (MGR), Specific Growth Rate (SGR), Absolute Growth Rate (AGR), Relative Growth Rate (RGR), Condition Factor (CF) were computed and evaluated for sex effect. All statistical analyses involving descriptive, general linear model analysis of variance (ANOVA) and post hoc test were done using Minitab® 17 Statistical Software. Sex had significant (P<0.05) effects on all growth parameters except Absolute Growth Rate (AGR) albeit at different levels, but specie only had significant (P<0.05) effect on Mean Growth Rate (MGR), while the interaction of sex x specie exerted significant (P<0.05) effects on all growth parameters except Condition Factor (CF). This study revealed that growth performance is significantly (P<0.05) affected by sexual dimorphism and also by interaction of sex and specie.
Impacts of a Seven Factor Model on Gil Stock Price – A Case in Vietnam
Authors: Dung Pham Anh , Huy Dinh Tran Ngoc , Han Le Thi , Nhan Pham Hung , Hien Dinh Tran Ngoc
Published: April 2024

Fluctuation of stock price in ex-import and textile system in developing countries such as Vietnam will reflect the business health of economic system. Based on the above data analysis from our regression model, although low inflation during 2015-2016 is a good signal for GIL stock price, we would suggest the government, Ministry of Finance and State Bank of Vietnam consider to control inflation more rationally, i.e not increasing much and suitable with each economic development stage. Governmental bodies and bank system also need to apply macro policies to stimulate economic growth, however not reducing lending rate too much, together with credit, operational and market risk management, corporate governance and controlling bad debt. This research finding and recommended policy also can be used as reference in policy for ex-import and textile system in many developing countries.
IMPORTÂNCIA DO SUPORTE BÁSICO DE VIDA NA PRIMEIRA RESPOSTA A EMERGÊNCIAS MÉDICAS
Authors: Lima Prado Yasmim , Primo Borges Lauhanda , Sarah Luiza Santos Rocha  , Júlia Carneiro Melo Silva  , Alves de Lima Marília Gabryella , Tamires Santana de Jesus Santos  , José Mário Delaiti de Melo  , Isabella Ferreira Nascimento  , Kelcione Pinheiro Lima Joter  , Henrique Costa Paulo
Published: April 2024

Introdução: O Suporte Básico de Vida (SBV) é uma intervenção inicial realizada por socorristas e profissionais de saúde para manter a vida e estabilizar os pacientes em situações de emergência médica. Essa abordagem consiste em técnicas simples, mas essenciais, que visam manter a circulação sanguínea e a oxigenação dos tecidos até que cuidados médicos mais avançados possam ser administrados. Objetivo: Este estudo visa descrever a relevância do SBV na primeira resposta a emergências, abordando suas principais técnicas, o treinamento necessário para sua aplicação e seu impacto na sobrevida dos pacientes. Metodologia: Este estudo consiste em uma revisão da literatura sobre a importância do suporte básico de vida na primeira reposta a emergências médicas realizada em março de 2024, com base em uma revisão integrativa da literatura científica na base de dados SciELo. Resultados e discussão: É evidente a importância do suporte básico de vida na manutenção das funções vitais durante situações de emergência, incluindo a ressuscitação cardiopulmonar, a desobstrução das vias aéreas e o controle de hemorragias. Além disso, evidências mostram que a aplicação adequada do SBV aumenta significativamente as taxas de sobrevivência em casos de parada cardiorrespiratória e outras emergências. Conclusão: O SBV desempenha um papel crucial na resposta inicial a emergências médicas, sendo essencial para preservar a vida dos pacientes até a chegada de cuidado avançados. Ao enfatizar a importância da atualização constante das diretrizes de RCP e do acesso a equipamentos como desfibriladores automáticos externos, fortalecemos ainda mais a capacidade da comunidade de resposta de forma eficaz a emergências médicas.