bluuebunny/crossref_metadata_2025 huggingface dataset:
Ethosome Containing Ceramide as a Skin Carrier of Active Ingredients
Authors: Hyeon Tong-Il , Yoon Kyung-Sup
Published: July 2022

Background:

Numerous formulations have been utilized in the cosmetic and pharmaceutical
industries to effectively deliver bioactive ingredients.

Methods:

We selected a well-known liposomal formulation of bilayer lipid vesicles composed of
ceramide NP. Ethosomes contain hydrophilic vanillic acid or lipophilic α-bisabolol, and their physicochemical
properties were evaluated. Vanillic acid is encapsulated in the aqueous core while α-bisabolol
is engaged with the lipid phase. The formulation was prepared by the high-pressure homogenization
method at 800 bar for 5 min. The particle size, polydispersity index and zeta potential of the ethosome
dispersion were analyzed by dynamic light scattering. In order to measure the skin absorption efficiency
from artificial skin, an in vitro assay was performed using the Franz diffusion cell method for 24 hours.
In addition, ultracentrifuges for encapsulation efficiency, dialysis membranes for active ingredient release,
and low-temperature transmission electron microscopy (TEM) to evaluate the morphology of
vesicles were utilized.

Results:

The particle size of the ethosome containing ceramide NP and vanillic acid was in the range of
80 ~ 130 nm, whereas the particle size of the ethosome containing ceramide NP and α-bisabolol was
150 ~ 170 nm. In the vanillic acid-containing ethosome, increasing the amount of ceramide NP decreased
the particle size, whereas the size of the α-bisabolol ethosome did not change. The stability of
the prepared ethosome did not change significantly for 4 weeks at 25°C, 4°C, and 45°C. The skin absorption
efficiency of ceramide NP and vanillic acid-containing ethosome was increased by about 15%
compared to the control group, whereas the ethosome containing α-bisabolol and ceramide NP showed
slightly higher skin absorption efficiency than the control group. In addition, encapsulation efficiency
evaluation, active ingredient release measurement and cryo-TEM were taken.

Conclusion and Perspective:

Based on the results of these studies, we suggest that ethosome formulations
containing ceramide NP can be widely used in the cosmetic industry together with other cosmetic
formulations.
Fungi and their Importance in Sustainable Agriculture
Authors: Rajesh N. , Shankar A. Shiva , Basha P. Osman
Published: July 2022

Soil fungi constitute a key component of agroecosystems because they
provide green services that influence food and bio-product production. Entophytic
fungi play a major role in growth promotion and relieve biotic and abiotic stresses in
plants. Phyto-hormones, antimicrobial agents, agrochemical bioactive metabolites
produced by fungal endophytes enhance sustainable agriculture. Because of soaring
cost and pollution-related issues, interest has shifted towards various methods like the
use of biofertilizers and bioinsecticides to control pests. Biofertilizers and

bioinsecticides are safe and cost-effective alternatives to chemical pesticides and are
considered high potential fertilizers because of their wide range of plant growth.promoting activities. The present chapter describes the role of endophytic fungi in the
agriculture sector.
Fungi: An Environment-friendly Approach for the Growth of Plants
Authors: Gunjal Aparna B.
Published: July 2022

The use of chemical fertilizers improves plant growth growth and causes
pollution, affecting human health. The use of microorganisms to increase the plant
yield has many advantages viz., eco-friendly, economical, and easy. The fungi produce
many secondary metabolites and can be used to promote plant growth. This will be a
sustainable approach and also avoid pollution. The fungi produce plant growth
promoting substances, act as strong biocontrol agents, and also show antimicrobial
effects against the harmful pathogens, thus preventing the diseases of the plants. This
chapter focuses on the importance of fungi in agriculture, which will help farmers. The
solid-state fermentation using Aspergillus sp. for plant growth-promoting substances is
also mentioned in the chapter. The chapter is significant as it highlights the use of the
biological process to improve plant growth, which is the need of the hour.
Perfil del administrador público en Colombia: una mirada desde la industria 4.0 y la apropiación social del conocimiento
Authors: Urrego Estrada Gleidy , Jurado Zambrano Diego Armando , Gutiérrez Ossa Jahir Alexander
Published: July 2022

Introduction: Restructuring aspects within public organizations, one of them was the issue of professionalization of the public service, although this was initially raised for the high bureaucracy, as a starting point for managerial reform. Objective: The purpose of the article is to reflect on the relationship of the profile of the public administrator in Colombia from the social appropriation of knowledge and the challenges that industry 4.0 implies. Reflection: For both industry 4.0 and the social appropriation of knowledge, the profile of the Public Administrator is based on research and technological development and innovation in the organization and management of the State, citizenship and construction of the public. Conclusions: they correspond to the challenges of the profile of the professional in Public Administration, which must be clearly noticed the bet of what it implies to be located in the orientation of the methods and / or methodologies of research focused on the appropriation of knowledge and the use of technologies related to industry 4.0 that should lead to innovative products and services.
Transitivity analysis of news texts on the Saudi ministry of health website: An investigation of health guidelines during COVID-19
Authors:   Department of English Language and Translation, Saudi Electronic University, Riyadh, Saudi Arabia, Alhumsi Mohammad Husam , Alshagrawi Salah ,   Public Health Department, College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia
Published: July 2022

The aim of this study is to investigate the awareness-raising activities and the health guidelines for protection from new coronavirus during this pandemic reported on the Ministry of Health website in Saudi Arabia. To achieve this aim, the study employs critical discourse analysis (CDA) of Halliday’s theory of transitivity process types adopted as a framework of news text. Literature showed that discourse analysis is an interdisciplinary area of investigation and an increasingly popular domain strategy for scholars in different fields. However, such a strategy has been little adopted by healthcare researchers. To analyze the transitivity process types (namely material, mental, verbal, relational, behavioral, and existential), quantitative and qualitative approaches were employed to get a better understanding of transitivity process types related to the news texts. Like other studies, the findings revealed that the material process type (60%) highly dominated the discourse in the two news texts. This implies the powerful role of events and actions to be undertaken. Unlike the first news text, the second news text however contains the behavioral process to meticulously highlight public awareness and action. Investigating participants’ roles as well as circumstances components may offer more data appropriate for further research.
The Association Between Telemedicine Use and Changes in Health Care Usage and Outcomes in Patients With Congestive Heart Failure: Retrospective Cohort Study
Authors: Chu Cherry , Stamenova Vess , Fang Jiming , Shakeri Ahmad , Tadrous Mina , Bhatia R Sacha
Published: July 2022

Background

Telemedicine use has become widespread owing to the COVID-19 pandemic, but its impact on patient outcomes remains unclear.

Objective

We sought to investigate the effect of telemedicine use on changes in health care usage and clinical outcomes in patients diagnosed with congestive heart failure (CHF).

Methods

We conducted a population-based retrospective cohort study using administrative data in Ontario, Canada. Patients were included if they had at least one ambulatory visit between March 14 and September 30, 2020, and a heart failure diagnosis any time prior to March 14, 2020. Telemedicine users were propensity score–matched with unexposed users based on several baseline characteristics. Monthly use of various health care services was compared between the 2 groups during 12 months before to 3 months after their index in-person or telemedicine ambulatory visit after March 14, 2020, using generalized estimating equations.

Results

A total of 11,131 pairs of telemedicine and unexposed patients were identified after matching (49% male; mean age 78.9, SD 12.0 years). All patients showed significant reductions in health service usage from pre- to postindex visit. There was a greater decline across time in the unexposed group than in the telemedicine group for CHF admissions (ratio of slopes for high- vs low-frequency users 1.02, 95% CI 1.02-1.03), cardiovascular admissions (1.03, 95% CI 1.02-1.04), any-cause admissions (1.03, 95% CI 1.02-1.04), any-cause ED visits (1.03, 95% CI 1.03-1.04), visits with any cardiologist (1.01, 95% CI 1.01-1.02), laboratory tests (1.02, 95% CI 1.02-1.03), diagnostic tests (1.04, 95% CI 1.03-1.05), and new prescriptions (1.02, 95% CI 1.01-1.03). However, the decline in primary care visit rates was steeper among telemedicine patients than among unexposed patients (ratio of slopes 0.99, 95% CI 0.99-1.00).

Conclusions

Overall health care usage over time appeared higher among telemedicine users than among low-frequency users or nonusers, suggesting that telemedicine was used by patients with the greatest need or that it allowed patients to have better access or continuity of care among those who received it.
Prediction of Specific Anxiety Symptoms and Virtual Reality Sickness Using In Situ Autonomic Physiological Signals During Virtual Reality Treatment in Patients With Social Anxiety Disorder: Mixed Methods Study
Authors: Chun Joo Young , Kim Hyun-Jin , Hur Ji-Won , Jung Dooyoung , Lee Heon-Jeong , Pack Seung Pil , Lee Sungkil , Kim Gerard , Cho Chung-Yean , Lee Seung-Moo , Lee Hyeri , Choi Seungmoon , Cheong Taesu , Cho Chul-Hyun
Published: July 2022

Background

Social anxiety disorder (SAD) is the fear of social situations where a person anticipates being evaluated negatively. Changes in autonomic response patterns are related to the expression of anxiety symptoms. Virtual reality (VR) sickness can inhibit VR experiences.

Objective

This study aimed to predict the severity of specific anxiety symptoms and VR sickness in patients with SAD, using machine learning based on in situ autonomic physiological signals (heart rate and galvanic skin response) during VR treatment sessions.

Methods

This study included 32 participants with SAD taking part in 6 VR sessions. During each VR session, the heart rate and galvanic skin response of all participants were measured in real time. We assessed specific anxiety symptoms using the Internalized Shame Scale (ISS) and the Post-Event Rumination Scale (PERS), and VR sickness using the Simulator Sickness Questionnaire (SSQ) during 4 VR sessions (#1, #2, #4, and #6). Logistic regression, random forest, and naïve Bayes classification classified and predicted the severity groups in the ISS, PERS, and SSQ subdomains based on in situ autonomic physiological signal data.

Results

The severity of SAD was predicted with 3 machine learning models. According to the F1 score, the highest prediction performance among each domain for severity was determined. The F1 score of the ISS mistake anxiety subdomain was 0.8421 using the logistic regression model, that of the PERS positive subdomain was 0.7619 using the naïve Bayes classifier, and that of total VR sickness was 0.7059 using the random forest model.

Conclusions

This study could predict specific anxiety symptoms and VR sickness during VR intervention by autonomic physiological signals alone in real time. Machine learning models can predict the severe and nonsevere psychological states of individuals based on in situ physiological signal data during VR interventions for real-time interactive services. These models can support the diagnosis of specific anxiety symptoms and VR sickness with minimal participant bias.

Trial Registration

Clinical Research Information Service KCT0003854; https://cris.nih.go.kr/cris/search/detailSearch.do/13508
Integrating Natural Language Processing and Interpretive Thematic Analyses to Gain Human-Centered Design Insights on HIV Mobile Health: Proof-of-Concept Analysis (Preprint)
Authors: Skeen Simone J , Jones Stephen Scott , Cruse Carolyn Marie , Horvath Keith J
Published: July 2022

BACKGROUND

HIV mobile health (mHealth) interventions often incorporate interactive peer-to-peer features. The user-generated content (UGC) created by these features can offer valuable design insights by revealing what topics and life events are most salient for participants, which can serve as targets for subsequent interventions. However, unstructured, textual UGC can be difficult to analyze. Interpretive thematic analyses can preserve rich narratives and latent themes but are labor-intensive and therefore scale poorly. Natural language processing (NLP) methods scale more readily but often produce only coarse descriptive results. Recent calls to advance the field have emphasized the untapped potential of combined NLP and qualitative analyses toward advancing user attunement in next-generation mHealth.

OBJECTIVE

In this proof-of-concept analysis, we gain human-centered design insights by applying hybrid consecutive NLP-qualitative methods to UGC from an HIV mHealth forum.

METHODS

UGC was extracted from Thrive With Me, a web app intervention for men living with HIV that includes an unstructured peer-to-peer support forum. In Python, topics were modeled by latent Dirichlet allocation. Rule-based sentiment analysis scored interactions by emotional valence. Using a novel ranking standard, the experientially richest and most emotionally polarized segments of UGC were condensed and then analyzed thematically in Dedoose. Design insights were then distilled from these themes.

RESULTS

The refined topic model detected K=3 topics: A: disease coping; B: social adversities; C: salutations and check-ins. Strong intratopic themes included HIV medication adherence, survivorship, and relationship challenges. Negative UGC often involved strong negative reactions to external media events. Positive UGC often focused on gratitude for survival, well-being, and fellow users’ support.

CONCLUSIONS

With routinization, hybrid NLP-qualitative methods may be viable to rapidly characterize UGC in mHealth environments. Design principles point toward opportunities to align mHealth intervention features with the organically occurring uses captured in these analyses, for example, by foregrounding inspiring personal narratives and expressions of gratitude, or de-emphasizing anger-inducing media.
An mHealth App to Promote Adherence to Immunosuppressant Medication and Track Symptoms in Children After Hematopoietic Stem Cell Transplant: Protocol for a Mixed Methods Usability Study (Preprint)
Authors: Skeens Micah , Sezgin Emre , Stevens Jack , Landier Wendy , Pai Ahna , Gerhardt Cynthia
Published: July 2022

BACKGROUND

In the United States, poor adherence accounts for up to 70% of all medication-related hospital admissions, resulting in $100 billion in health care costs annually. In pediatrics, adherence is largely dependent on caregivers. In a high-risk hematopoietic stem cell transplant (HSCT) population, caregivers are isolated with their child due to infection risk and must manage challenging treatment regimens at home, often with limited time and support. Complex behavioral interventions, typically employed to address adherence, are difficult to deliver and manage in the context of these daily tasks. The most successful adherence interventions, and thus improved clinical outcomes, have included mobile health (mHealth) reminder approaches and a direct measure of adherence.

OBJECTIVE

This is a 3-phase project, with this protocol describing phase 2, to determine the usability and feasibility of an mHealth app (BMT4me) designed to promote adherence to immunosuppressant medication and to track symptoms among children who received HSCT.

METHODS

This study uses an iterative convergent mixed methods design to develop and assess the usability and feasibility of an adherence digital health intervention. We will recruit 15 caregivers of pediatric patients receiving HSCT to complete user testing. Qualitative and quantitative data will be integrated to enhance and expand upon study findings.

RESULTS

Enrollment began in September 2021 and is ongoing. A total of 7 caregivers have enrolled. We anticipate completion by fall 2022. We anticipate high usability scores and a better understanding of unique features within the app that are needed for HSCT families post transplant. To date, usability scores among enrolled participants are greater than 70%. Feedback from qualitative interviews is being used to further adapt the app by adding specific weekly logs, call provider options, and voice to text.

CONCLUSIONS

This protocol describes a mixed methods usability and feasibility study to develop and implement a smartphone app for caregivers of children receiving HSCT. The app was designed to improve immunosuppressant adherence and to track symptoms in the acute phase post discharge. Study findings will inform further refinement of the app and the feasibility of a pilot randomized controlled trial examining efficacy on clinical outcomes.

CLINICALTRIAL

ClinicalTrials.gov NCT04976933; https://clinicaltrials.gov/ct2/show/NCT04976933

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/39098
Virtual multidisciplinary ALS clinic care during the COVID-19 pandemic: clinical outcomes in a Canadian cohort (Preprint)
Authors: Gariscsak Peter Joseph , Appireddy Ramana , Vyas Aarti , Ritsma Benjamin R
Published: July 2022

BACKGROUND

The COVID-19 pandemic brought significant challenges to ALS care, which is recommended to include provision within specialized multidisciplinary clinics, and further highlighted the potential for virtual care (VC) strategies. There is very limited data pertaining to clinical outcomes associated with VC in ALS.

OBJECTIVE

In the ALS Clinic context, we aimed to assess the impact of VC on patient-reported quality of life (QOL), clinical progression, caregiver burden, and travel distance/time savings.

METHODS

Eleven participants with ALS, receiving synchronous virtual multidisciplinary ALS Clinic care, had baseline and 6-month follow-up outcome data compared across the EQ-5D-5L, ALS Functional Rating Scale-Revised (ALSFRS-R), Clinical Frailty Scale (CFS), and Zarit Burden Interview (ZBI). VC was provided by video or audio-based platforms.

RESULTS

For QOL via EQ-5D-5L, improvement was noted on several dimensions, including Anxiety/Depression, while the Paretian Classification of Health Change identified general stability. Mean (SD) EQ-VAS patient percieved health scores trended towards improvement [51.3 (22.3) to 57.4 (21.6) (P=.591)]. Mean ALSFRS-R scores declined 0.62 points per month, while mean (SD) CFS scores increased [5 (1.48) to 5.8 (1.14)]. Mean (SD) ZBI caregiver burden scores trended down [24.67 (17.61) to 20.83 (16.68) (P=.334)], as did the proportion with high burden [55.5% to 33.3% (P=.400)]. Mean travel distance/time saved per patient per visit was 167.8 km/1 hour 54 minutes.

CONCLUSIONS

We demonstrate successful application of synchronous virtual multidisciplinary ALS Clinic care, noting improvement in several patient-reported QOL domains, trends towards reduced caregiver burden, and considerable reduction in travel time over an interval with expected clinical progression.
Characterization of Global Research Hotspots and Trends on Ten-eleven Translocation 2: Visualization and Bibliometric Analysis (Preprint)
Authors: Lv Hao , Gao Ziang , Wang Yunfei , Liu Peiqiang , Qin Danxue , Zhou Huiqin , Xu Yu
Published: July 2022

BACKGROUND

Ten-eleven translocation (TET) methylcytosine dioxygenase 2 is an essential DNA demethylase that plays an important role in a variety of biological and pathological processes. However, no bibliometric analysis has methodically explored the knowledge domain of TET2 research.

OBJECTIVE

The aim of this study is to conduct a visual and scientometric analysis of TET2 research and to explore its current landscape, future direction, and research frontiers.

METHODS

Publications related to TET2 research were retrieved from the Web of Science Core Collection (WoSCC) from 2009 to 2021. Excel, CiteSpace, and VOSviewer were used to perform the bibliometric visualization analysis.

RESULTS

A total of 2384 articles were retrieved. The number of publications on TET2 has been steadily increasing from 2009 to 2021. The USA is the largest contributor to the topic, with the largest number of publications. Harvard University and the Institut National de la Santé et de la Recherche Médicale were the leading institutions. Levine RL of Memorial Sloan-Kettering Cancer Center is the most prolific and influential author. High-frequency keywords were “tet2”, “DNA methylation”, “5-hrdroxymethylcytosine”, “5-methylcytosine”, “mutations”, “acute myeloid-leukemia”. The emerging research hotspots, according to keyword bursts, include “inflammation”, “gene expression”, “landscape” and “clonal hematopoiesis”.

CONCLUSIONS

Research with regards to TET2 is constantly evolving and deepening. We provide an objective and comprehensive analysis of the global status, research hotspots, and potential trends in the field of TET2 research by using a bibliometric approach. These results will assist researchers and clinicians in mastering the knowledge structure and future directions of TET2 research, thus guiding follow-up research.
Authors’ Response to Peer Reviews of “Are We Sure We Fully Understand What an Infodemic Is? A Global Perspective on Infodemiological Problems” (Preprint)
Authors: Rovetta Alessandro , Castaldo Lucia
Published: July 2022

UNSTRUCTURED

This is the authors' responses to peer review reports related to ms#36510.
Health Care Professionals’ Experiences in Telerehabilitation: Qualitative Content Analysis (Preprint)
Authors: Qvarfordt Maria , Nilsson Evalill , Nilsson Lina
Published: July 2022

BACKGROUND

The use of digital communication in Swedish health care has increased in an effort to make health care more accessible. At the organizational level, trust in digitalization has stabilized, but a certain degree of skepticism regarding technology appears to exist among health care employees.

OBJECTIVE

This study aimed to explore health care professionals’ (HCPs) experiences of digital communication with patients and colleagues in a habilitation context.

METHODS

Qualitative content analysis was used to analyze data derived from individual interviews.

RESULTS

The results revealed that there were mixed feelings regarding the digital format used at the habilitation center. Although some skepticism remained regarding the digital format, there seemed to be a parallel understanding of the motives and benefits of digitalization. Hence, positive aspects, such as increased health care accessibility, were identified. However, emphasis was placed on the considerations required to make digital consultations appropriate for each patient.

CONCLUSIONS

Managing a workday influenced by the balance between digital and physical demands forces HCPs to adjust to the digital format and new ways of working. This requires HCPs to consider whether digital means are appropriate for communication in individual patient-specific cases.

CLINICALTRIAL
Export collapse and employment effects during the Covid-19 crisis in Mexico
Authors: Villanueva Luis , Jiang Xiao
Published: July 2022

We study the employment effects of the collapse of Mexican exports to the USA due to the Covid-19 crisis and its recovery. The employment outcomes are broken down by gender and skill, which enables the investigation to assess how these employment categories were affected. The article finds that 33.6% of all the jobs lost at the height of the Covid-19 pandemic in Mexico were exclusively due to the collapse of exports to the USA. Trade collapse was biased against female and unskilled workers, although all the jobs lost were re-gained during the recovery, being again biased against female workers. Gender-responsive policies are needed to ensure an inclusive recovery and resilience against future trade shocks.
An Analytical Study on Performance of Soyabean Crop in India
Authors: Rani Dr Prabha
Published: July 2022

Abstract: Agriculture is backbone of the Indian Economy. Agriculture sector provides food security for the entire population and provide raw material to many agro industries. Oilseed crops are the second most important determinant of agricultural economy, next only to cereals within the segment of field crops. India is one of the largest producers of oilseeds in the world and occupies an important position in the Indian agricultural economy. Soybean contributes significantly to the Indian edible oil pool. Presently soybean contributes 43 % to the total oilseeds and 25% to the total oil production in the country. Currently, India ranks fourth in respect to production of soybean in the world. In the present paper, an analytical study has been taken up for the production trend and growth rate by using three years moving average for area sown, productivity and production for Soyabean crop. State-wise analysis has also been carried out for Soyabean producing States. The future projection for production and productivity have also been worked out. In view of the importance of this sector for ensuring inclusive growth and the need to achieve self-sufficiency in oilseeds production, key challenges faced by the edible oils sector and the strategy to address them are also spelled out.
Miles Atime
Authors: K G Sahana
Published: July 2022

Abstract: As tourism is one of the fastest growing industries today, thus within the tourism industry events are getting more and more important. People have become more interested in events of all kinds, and will travel far away to participate in events that they find interesting. Events can offer various economic and social benefits for destinations, and therefore destination managers can and should employ events effectively in a tourism role. It has become widely accepted that every community and destination need to adopt a long-term, strategic approach to event tourism thereby planning and development in order to realize the full tourism potential of events. This study was launched as a response to the lack of studies on how Tours strategies are actually used in destinations. The study was directed to tours and travel management system and the aim was to explore Tour and Travel packages. We offer tour and travel services including ticket bookings, hotel reservations, rental car services, holiday tour packages, domestic tour packages. We provide the most suitably designed as well as the customized travel packages to the customers. We offer everything related to travelling services under one roof
Discretion in the Activities of Non-State Law Enforcement Agencies
Authors:   Russian Presidential Academy of National Economy and Public Administration, Zelensky P.A. , Khaliulin V.E. ,   Russian Presidential Academy of National Economy and Public Administration
Published: July 2022

Problems of law enforcement discretion in the activities of non-state law enforcement agencies are analyzed. The authors come to the conclusion about the increasing role of non-state actors in law enforcement and specific manifestations of discretion in this activity that require further comprehensive research.
Feather characteristics for eye protection in an insectivorous passerine: the Iberian grey shrike Lanius meridionalis, in southern France
Authors: Labouyrie Frédéric
Published: July 2022

In the French Mediterranean plain, the northern extreme of its native
range, the Iberian grey shrike, Lanius meridionalis, predominantly feeds
on arthropods. Its type of loral plumage plays a key role in protecting
its eyes while transporting large prey. The aims is to understand the
role played by feathers in protecting the animal from various types of
defensive prey. We combine an inspection of large insect prey types
found on larders with a review of bird specimens found in museum
collections to examine the morphometric characteristics of rictal
feathers and culmen. In addition, precision photographs are used to
observe the posture of the plumage in natura. We could identify four
categories of protective feathers: clustered bristles, semi-bristles,
semi-plumes distributed in the loral area, and semi-plumes above the
eyes. Our results suggest that the Iberian grey shrike has a complex
structure of loral feathers, specific to its foraging activity and prey
types. In France, local species have longer beaks than their Spanish
counterparts which suggests a more insect-based diet.
Polypharmacotherapy and cumulative anticholinergic burden in older adults hospitalised with fall
Authors: Wong Ho Lun , Weaver Claire , Marsh Lauren , Mon Khine , Dapito John , Chauhan Rahul , Mandal Amit , Missouris Constantinos , Amin Fouad
Published: July 2022

Background and Purpose Polypharmacotherapy is a growing phenomenon
associated with adverse effects in older adults. We assessed the
potential confounding effects of cumulative anticholinergic burden (ACB)
in patients who were hospitalised with falls. Methods A
non-interventional, prospective cohort study of unselected, acute
admissions aged ≥65 years. Data were derived from electronic patient
health records. Results were analysed to determine the frequency of
polypharmacotherapy and degree of ACB and their relationship to falls
risk. Primary outcomes were polypharmacotherapy, defined by ≥5
medications, and ACB score. Key Results 411 consecutive subjects were
included, mean age 83·8 ± 8·0 years: 40·6% male. 38·4% were admitted
with fall. Incidence of polypharmacotherapy was 80·8%, (88·0% and
76·3% among those admitted with and without fall respectively).
Incidence of ACB score of 0, 1, 2, ≥3 was 38·7%, 20·9%, 14·6% and
25·8% respectively. On multivariate analysis, age (OR=1·03, [1·0 ;
1·05], p= 0·0494), ACB score (OR=1.15, [1.02 ; 1.29], p= 0.0245),
polypharmacotherapy (OR=2·14, [1·19 ; 3·87], p= 0·0115) but not
Charlson Comorbidity Index (OR=0·92, [0·81 ; 1·04], p= 0·1723) were
significantly associated with higher falls rate. Of patients admitted
with fall, 29·8% had drug-related orthostatic hypotension, 24·7% had
drug-related bradycardia, 37·3% were prescribed centrally acting drugs
and 12·0% were taking inappropriate hypoglycaemic agents.
Interpretation Polypharmacotherapy results in cumulative ACB and both
are significantly associated with falls risk in older adults. The
presence of polypharmacotherapy and each unit rise in ACB score have a
stronger effect of increasing falls risk compared to age and
comorbidities.
Ethylene signaling plays an important role in UV-B-induced ascorbic acid accumulation in Cucumis Sativus leaves
Authors: Liu Peng , Li Qiang , Wang Heng , Lu Tao , Li Yang , Sui Xiaolei , Yu Hongjun , Jiang Weijie
Published: July 2022

UV-B regulates the metabolism of many important substances, such as
hormones, ascorbic acid (AsA) and secondary metabolites. However, the
mechanism by which UV-B regulates AsA metabolism, especially signal
transduction, is largely unclear. Here, we report that UV-B promotes the
accumulation of AsA and the production of ethylene in cucumber
seedlings. However, when the ethylene signal is blocked, UV-B no longer
promotes the accumulation of AsA in cucumber leaves. This indicates that
the ethylene signal is a key factor enabling UV-B to regulate AsA
levels. The q-PCR results show that UV-B induces the expression of the
CsACO and CsACS genes, which, in turn, promotes the
biosynthesis of ethylene; thus, ethylene production is promoted and the
ethylene signal is activated. Moreover, the expression of the ethylene
response factor CsERF39 is up-regulated through a series of UV-B
signal transduction. Knockout of CsERF39 and CsGLDH
results in a reduced AsA pool in cucumber leaves. Furthermore, we
identified CsGLDH as a direct target for CsERF39 to regulate AsA
biosynthesis, by q-PCR analysis, molecular experiments and genetic data.
Therefore, CsACS, CsACO, CsERF39 and CsGLDH
are involved in the regulation of AsA biosynthesis by UV-B through the
ethylene signal transcription cascade.
About the Teleportation of a Proton
Authors: AB Jebara
Published: July 2022

“Let us try to describe an experiment where a proton travels a distance in a given time and another experiment where it travels the same distance in no time. After the coupling of 2 protons, the proton which is taken away should instead be left moving by itself. The particle could teleport itself without it being a teleportation of information only”.
Study of Nano-Al2O3 + Nano-SiO2 + H2O System by Fourier-IRSpectroscopy Method
Authors: SZ Melikova
Published: July 2022

The radiation-thermal decomposition of water in the nano-Al2 O3 +nano-SiO2 +H2 O system in the temperature range (T=373÷673K) under the influence of -rays using Fourier transform IR spectroscopy has been studied. Intermediate-active products of radiation-heterogeneous decomposition of water such as aluminum and silicon hydrides, hydroxyl groups have been registered. It was determined that in this heterosystem, an absorption dose of 10 kGy occurs in the radiation-chemical decomposition of water.
Problematics of Improving Fine Motor Abilities of Children Age 5-6 Years
Authors: Isnaini Rizki , Katoningsih Sri
Published: July 2022

Fine motor skills are an aspect of development that is emphasized in early childhood education. AbilityFine motor skills are developed from an early age in order to have the skills to coordinate the eye and hand. The research objective is to examine the literature, articles and research documents that identify problems in improving fine motor skills of early childhood. Methods: references in the form of primary articles of approximately 20 articles 15 national journals with a period of 5 years and international journals with a period of 7 years with accredited quality and reputation. This research uses qualitative research with literature review method. The samples of this research are: 1) Related to fine motoric development of early childhood, 2) Respondents are early childhood, 3) The independent variable is problematics and the dependent variable is fine motor skills, 4) The treatment given is a problem which can improve fine motor skills. Results and discussion: The Literature Review states that media can affect fine motor skills, including pencil shavings collage,constructive play with paper, unit beam, playdough, kirigami. method can have an effect on improving fine motor skills, that isu aquatic / water learning, cutting activities, collage activities, cutting and pasting activities, demonstration methods, printing activities using banana leaves, coloring pictures, practical life in montessori education, interactive writing. There are several factors that can affect the improvement of fine motor skills, namely counseling through play activities, learning plans, learning preparation, learning environment, being overweight, and motivation.. Conclusion: learning media, learning methods are problems that do not dominate, but there are other factors that are problematic in improving fine motor skills, including counseling through play activities, lesson plans, learning preparation, learning environment, overweight, and motivation.
Implementation of the Development of Moral Religious Values in Early Childhood Through Modeling Methods
Authors: Safitri Eva
Published: July 2022

The development of children's religious and moral values is the child's ability to behave and behave. The development of moral religious values for children is related to polite behavior, maintaining good speech, adhering to religious teachings in life. The purpose of this study was to analyze the development of moral religious values in early childhood through exemplary methods. This research uses qualitative research with a literature review method. Methods: References in the form of primary articles of approximately 20 articles, 15 national journals with a period of 5 years, and international journals with a term of 7 years that are accredited and reputable. The sample of this research is related to the value of moral religion in children / exemplary methods with journal criteria selected were: 1) an experimental research; 2) respondents are early childhood; 3) the independent variable is an exemplary method and the dependent variable is the development of religious and moral values; 4) the treatment given is exemplary influence / another factor that can increase the development of religious and moral values in early childhood. Results and discussion: the literature review states that the moral religious values of children in this study are exemplary parents and teachers, exemplary is a dominant problem, the development of children's religious and moral values can be influenced by several factors, including deliberate and unintentional role models, use of audio-visual media, storytelling method, VCD media, role-playing, singing method, habituation method, traditional games, IMTAQ center. Conclusion: exemlpary methods can influence children’s development and the development of moral religious values can be developed in a variety of ways.
Training Scenario Development on Environmental Education Using The STSE Model to Improve Positive Attitudes of Prospective Early Childhood Education Teachers towards The Environment
Authors: Muazar Habibi MA
Published: July 2022

The purpose of this research is to develop training scenarios on environmental education using Science, Technology, Society, Environment (STSE) model integrated into scientific thematic lessons, particularly for prospective early childhood teachers. In addition, product efficiency on the positive attitudes of the trainers towards the environment was examined. The above-mentioned objectives are possibly achieved with the following activities: 1) initializing the Borg Gall model (1999) and 2) assessing the resulting product value using t-test, termed pre-test and post-test. Therefore, the applied simulations were declared suitable for use after series of  developmental events.The results involved three expert assessments in the field of early childhood, environmental education, and educational technology, although further analysis is required. Subsequent investigation conducted on the subject user group, indicating a positive value of 83.3%, in support of the product.Therefore, the efficiency test results showed the training on environmental education using the STSE model and integrated with scientific thematic lessons, were known to enhance 32.44% of all aspects of the prospective teacher's positive attitudes on the environment.
Indonesian mathematics teachers’ views on distance learning barriers during the early Covid-19 pandemic
Authors: Julie Hongki , Rianasari Veronika Fitri , Apriani Maria Suci
Published: July 2022

The aim of this paper is to describe the views of mathematics teachers in Indonesia on the distance learning barriers during the early Covid-19 pandemic. Specifically, this paper investigates the barriers that teachers view as significant in distance learning and efforts taken to overcome the barriers during the early Covid-19 pandemic. This study employed a descriptive research design involving 415 mathematics teachers by snowball sampling to fill out an online questionnaire. This study shows that barriers related to pedagogical dimensions were perceived as significant in distance learning during the early Covid-19 pandemic. Moreover, this study reveals that most of the teachers did some efforts that can be done by the teachers themselves to overcome the barriers. Based on the findings, we argue that it is important to support teachers’ pedagogical competencies to conduct distance learning in order to face this current pandemic or any future crises that may potentially disrupt face-to-face learning.
Evaluasi Respon Kelompok Tani dalam Kegiatan Introduksi Budidaya Gandum
Authors: Prihtanti Tinjung Mary
Published: July 2022

Kebijakan pengembangan gandum mulai dirintis pemerintah Indonesia sejak tahun 1980-an saat Kementerian Pertanian mulai melakukan penelitian uji adaptasi gandum. Meski 30 tahun upaya pengembangan telah dilakukan, tetapi budidaya gandum tidak pernah menjadi tanaman penting dalam sistem usaha tani petani di Indonesia. Pengabdian ini bertujuan mengetahui respon kelompok tani terhadap introduksi gandum di lapangan. Analisis respon mengambil kasus dari kegiatan pengabdian masyarakat yakni introduksi budidaya tanaman gandum dilakukan di Desa Ngadirojo, Kecamatan Ampel, Kabupaten Boyolali di tahun 2018 dan di Desa Wates, Kecamatan Getasan, Kabupaten Semarang di tahun 2019. Analisis menggunakan pendekatan kualitatif dengan informan kunci yakni petani yang aktif dalam kegiatan pengabdian masyarakayt baik terlibat dalam budidaya gandum maupun tahap lain yang dilakukan. Hasil observasi kegiatan menunjukkan bahwa aspek relative advantage menjadi titik kritis dalam program introduksi gandum di tingkat kelompok tani, introduksi dengan pendekatan kelompok cukup efisien karena memungkinkan adanya umpan balik dari anggota kelompok tani dan memberi kesempatan bertukar pengalaman, dan faktor kepemimpinan ketua kelompok tani mempengaruhi respon positif dan keterlibatan anggota kelompok tani dalam kegiatan pengabdian masyarakat introduksi gandum.
Kolaborasi Aktor dalam Pemberdayaan Masyarakat Selama Pandemi Covid-19 Desa Jelgung Kabupaten Sampang
Authors: Hidayat Endik , Baihaqi Aufa Izzudin , Marta Rustono Farady
Published: July 2022

Changes in social life due to the Covid-19 pandemic also have an impact on the village level. The research carried out aims to review the model of community empowerment in the Covid-19 pandemic in Jelgung Village. As for the two questions that arise, what is the model of community empowerment of the Jelgung village government? Who are the actors involved in community empowerment in Jelgung village during the Covid-19 pandemic? This study will use qualitative methods, more specifically descriptive analysis at the village level. Qualitative data was obtained through in-depth interviews with informants consisting of actors involved in empowering village residents, namely village heads, village officials and community leaders. The results showed that empowerment in Jelgung village was driven by two main actors, namely individuals from community leaders and local and village governments. Meanwhile, empowerment activities are divided into two forms, namely labor intensive including training and capital intensive including small and medium business capital assistance.
Pemberdayaan Santri Pesantren Raden Rahmat Sunan Ampel Jember di Masa Pandemi Covid-19 melalui Produksi Rengginang Singkong
Authors: Diniyah Nurud , Purwandari Retno , Setiawan Dani , Leseni Ni Ketut , Yuwana Nugraha
Published: July 2022

The Raden Rahmat Sunan Ampel Islamic Boarding School located 2.1 km from Jember University on Jalan Koptu Berlian with students totaling approximately 70 from the University of Jember, Jember State Polytechnic and Muhammadiyah University of Jember. One of the boarding schools' efforts is to produce cassava’s rengginang. The problems faced by partners include nutritional content of cassava rengginang that has not been analyzed, the innovative potential and entrepreneurial spirit of the students, and the lack of understanding of stress management in the face of covid-19 pandemic. The solutions that can be offered from the proposing team to partner problems are providing training on rengginang production, training and mentoring of production, analysis of the nutritional content of cassava rengginang, mentoring students in participating in competitions, as well as additional activities, health and protocols related to covid prevention during the production process and stress management during the pandemic. The contribution from the partner audience is empowerment of students as participants and to train the entrepreneurial spirit, to be independent, creative and innovative and to be able to read business opportunities. The method of implementing this service activity is in the form of lectures, discussions, mentoring, practice and counseling. The results were carried out in several stages, namely the observation and coordination, counseling of material, the practice of making cassava rengginang, mentoring innovative soft skills and entrepreneurship, as well as conducting proximate tests on products, providing assistance with cassava raw materials and personal protective equipment such as masks, hand sanitizers and hand shoaps.
IMPACT OF THE INTERACTION OF MOVING PLANETS ON THEIR ORBITS
Authors:   Lviv Polytechnic National University, Сhaban Vasil
Published: July 2022

The research raises the problem of determining and measuring the interaction of planets on the trajectory of their orbits around the Sun. Its solution becomes possible only based on an adequate mathematical model. For this purpose, Newton's law of universal gravitation was adapted to the case of moving masses in a wide range of velocities in flat Euclidean space and physical time. The finite speed of propagating the gravitational field is considered. Differential equations of planets’ motion are obtained. Transients in the three-mass system of a star and two planets close to the Sun-Mercury-Venus system are simulated. To reveal deeply the essence of physical interaction, a hyperbolized transition process is simulated under artificially close moving masses.
ELECTRICAL PROPERTIES OF TI-CU-CO-SI HIGH-ENTROPY ALLOY
Authors:   Lviv Polytechnic National University, Yatsyshyn Svyatoslav , Skoropad Pylyp ,   Lviv Polytechnic National University, Karpinski Mikolaj ,   University of Bielsko-Biala
Published: July 2022

To study the metrological characteristics, there were studied manufactured based on the Ti-Cu-Co-Si alloy, obtained by quenching from the melt, the sensitive element of the resistance thermotransducer. The instability of its metrological characteristics as a function of temperature up to 350 oC and operation time up to 3000 hours was investigated; it does not exceed 0.025% under the worst operating conditions. In addition, the methodological error of measurement caused by heating of the sensitive element by the measuring current was examined. It was shown that the recorded changes in electrical resistance were outside the value of the methodological error. They may be due to the presence of nanostructured fields of mechanical stresses and the formation of nanoprecipitates as a consequence of manufacturing.
The implementation of Listen-Read-Discuss Strategy to improve the eleventh-grade students’ reading comprehension at SMAN 1 PenawarAji
Authors:   Universitas Lampung, Febiyanti Sayu Putuyana , Nurweni Ari ,   Universitas Lampung, Sukirlan Muhammad ,   Universitas Lampung
Published: July 2022

The aim of this research was to find out whether there was an improvement in students' reading comprehension after they were taught by using Listen-Read-Discuss (LRD) Strategy.The sample of this research was 30 students ineleventh grade of IPS 3 in SMA Negeri 1 Penawar Aji in academic year 2019/2020. The data were obtained after conducting the pretest and posttest.The result of this research shows that there is a significant improvement in students’ reading comprehension. It can be seen in the mean score of pretest which was 63.4 that improved to 71.2 in posttest and the t-value is 22.015 with df 19 meanwhile in t-table of 19 is 2.0930. It means that t-value is higher than t-table (22.015 > 2.0930). The significant value was 0.00, which was lower than 0.05. It indicated that H1 is accepted, and that there was a significant improvement in students’ reading comprehension after they were taught using Listen-Read-Discuss Strategy. It can be concluded that Listen-Read-Discuss Strategy could be used as an alternative technique to improve students’ reading comprehension. Keywords: listen-read-discuss, Listen-Read-Discuss Strategy, reading comprehension.